bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mother and Father Controlling Feeding Behaviors and Associations With Observed Mealtime Family Functioning
Authors: Westen Sarah C , Mitchell Tarrah B , Mayer-Brown Sarah , Resmini Rawlinson Alana , Ding Ke , Janicke David M 
Published: July 2019

Abstract

Objective
Mealtime family functioning is important in shaping health behaviors associated with overweight/obesity, particularly for preschool-aged children. Parental controlling feeding behaviors (i.e., restriction and pressure to eat), may impact mealtime family functioning and thus be targets of prevention and intervention efforts. The current study aimed to address literature gaps by examining both mother and father self-reports of controlling feeding behaviors, and the discrepancies between parents’ reports. Further, the study examined the associations among controlling feeding behaviors and objective mealtime family functioning in a community sample of preschool-aged children.

Methods
The sample included 27 children between 2 and 6 years of age and their immediate family members. Two mealtimes were videotaped for each family and coded for family functioning using the Mealtime Interaction Coding System, and self-reports of feeding practices were collected using the Child Feeding Questionnaire.

Results
Mother controlling feeding behaviors were not significantly related to any mealtime family functioning domain. Father controlling feeding behaviors were only significantly related to interpersonal involvement. However, discrepancies in the use of controlling feeding behaviors accounted for nearly one fourth of the variance in overall family functioning and affect management, with greater discrepancies being related to poorer family functioning.

Conclusions
Interventions may be designed to reduce parental discrepancies in the use of controlling feeding behaviors. Future research should consider longitudinal design, using larger, more representative samples, to better understand the impact of parental controlling feeding behaviors, particularly the impact of parental discrepancies in these areas, on mealtime family functioning and subsequent health outcomes.
A deeper look at the dust attenuation law of star-forming galaxies at high redshift
Authors: Tress M , Ferreras I , Pérez-González P G , Bressan A , Barro G , Domínguez-Sánchez H , Eliche-Moral C 
Published: July 2019

ABSTRACT
A diverse range of dust attenuation laws is found in star-forming galaxies. In particular, Tress et al. (2018) studied the SHARDS survey to constrain the NUV bump strength (B) and the total-to-selective ratio (RV) of 1753 star-forming galaxies in the GOODS-N field at 1.5 < z < 3. We revisit here this sample to assess the implications and possible causes of the correlation found between RV and B. The UVJ bicolour plot and main sequence of star formation are scrutinized to look for clues into the observed trend. The standard boundary between quiescent and star-forming galaxies is preserved when taking into account the wide range of attenuation parameters. However, an additional degeneracy – regarding the effective attenuation law – is added to the standard loci of star-forming galaxies in the UVJ diagram. A simple phenomenological model with an age-dependent extinction (at fixed dust composition) is compatible with the observed trend between RV and B, whereby the opacity decreases with the age of the populations, resulting in a weaker NUV bump when the overall attenuation is shallower (greyer). In addition, we compare the constraints obtained by the SHARDS sample with dust models from the literature, supporting a scenario where geometry could potentially drive the correlation between RV and B.
Star formation in CALIFA early-type galaxies: a matter of discs
Authors: Méndez-Abreu J , Sánchez S F , de Lorenzo-Cáceres A 
Published: July 2019

ABSTRACT
The star formation main sequence (SFMS) is a tight relation between the galaxy star formation rate (SFR) and its total stellar mass (M⋆). Early-type galaxies (ETGs) are often considered as low-SFR outliers of this relation. We study, for the first time, the separated distribution in the SFR versus M⋆ of bulges and discs of 49 ETGs from the CALIFA survey. This is achieved using c2d, a new code to perform spectrophotometric decompositions of integral field spectroscopy data cubes. Our results reflect that: (i) star formation always occurs in the disc component and not in bulges; (ii) star-forming discs in our ETGs are compatible with the SFMS defined by star-forming galaxies at z ∼ 0; (iii) the star formation is not confined to the outskirts of discs, but it is present at all radii (even where the bulge dominates the light); (iv) for a given mass, bulges exhibit lower sSFR than discs at all radii; and (v) we do not find a deficit of molecular gas in bulges with respect to discs for a given mass in our ETGs. We speculate our results favour a morphological quenching scenario for ETGs.
Structural intermediates of a DNA–ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation
Authors: Williamson Adele , Leiros Hanna-Kirsti S 
Published: July 2019

Abstract
DNA ligases join adjacent 5′ phosphate (5′P) and 3′ hydroxyl (3′OH) termini of double-stranded DNA via a three-step mechanism requiring a nucleotide cofactor and divalent metal ion. Although considerable structural detail is available for the first two steps, less is known about step 3 where the DNA-backbone is joined or about the cation role at this step. We have captured high-resolution structures of an adenosine triphosphate (ATP)-dependent DNA ligase from Prochlorococcus marinus including a Mn-bound pre-ternary ligase–DNA complex poised for phosphodiester bond formation, and a post-ternary intermediate retaining product DNA and partially occupied AMP in the active site. The pre-ternary structure unambiguously identifies the binding site of the catalytic metal ion and confirms both its role in activating the 3′OH terminus for nucleophilic attack on the 5′P group and stabilizing the pentavalent transition state. The post-ternary structure indicates that DNA distortion and most enzyme-AMP contacts remain after phosphodiester bond formation, implying loss of covalent linkage to the DNA drives release of AMP, rather than active site rearrangement. Additionally, comparisons of this cyanobacterial DNA ligase with homologs from bacteria and bacteriophage pose interesting questions about the structural origin of double-strand break joining activity and the evolution of these ATP-dependent DNA ligase enzymes.
Phosphorylation orchestrates the structural ensemble of the intrinsically disordered protein HMGA1a and modulates its DNA binding to the NFκB promoter
Authors: Kohl Bastian , Zhong Xueyin , Herrmann Christian , Stoll Raphael 
Published: July 2019

AbstractHigh Mobility Group Protein A1a (HMGA1a) is a highly abundant nuclear protein, which plays a crucial role during embryogenesis, cell differentiation, and neoplasia. Here, we present the first ever NMR-based structural ensemble of full length HMGA1a. Our results show that the protein is not completely random coil but adopts a compact structure consisting of transient long-range contacts, which is regulated by post-translational phosphorylation. The CK2-, cdc2- and cdc2/CK2-phosphorylated forms of HMGA1a each exhibit a different binding affinity towards the PRD2 element of the NFκB promoter. Our study identifies connected regions between phosphorylation sites in the wildtype ensemble that change considerably upon phosphorylation, indicating that these posttranslational modifications sites are part of an electrostatic contact network that alters the structural ensemble by shifting the conformational equilibrium. Moreover, ITC data reveal that the CK2-phosphorylated HMGA1a exhibits a different DNA promoter binding affinity for the PRD2 element. Furthermore, we present the first structural model for AT-hook 1 of HMGA1a that can adopt a transient α-helical structure, which might serve as an additional regulatory mechanism in HMAG1a. Our findings will help to develop new therapeutic strategies against HMGA1a-associated cancers by taking posttranslational modifications into consideration.
Dietary satisfaction and quality of life in chronic kidney disease patients on low-protein diets: a multicentre study with long-term outcome data (TOrino-Pisa study)
Authors: Piccoli Giorgina Barbara , Di Iorio Biagio Raffaele , Chatrenet Antoine , D’Alessandro Claudia , Nazha Marta , Capizzi Irene , Vigotti Federica Neve , Fois Antioco , Maxia Stefania , Saulnier Patrick , Cabiddu Gianfranca , Cupisti Adamasco 
Published: July 2019

AbstractBackgroundConcerns about adherence and quality of life (QoL) limit the diffusion of low-protein diets (LPDs) as a way to slow chronic kidney disease (CKD) progression and postpone dialysis. The aim of this multicentre study is to assess dietary satisfaction in stable CKD patients.MethodsThis was a multicentre cross-sectional study with long-term follow-up data. Prevalent patients on LPD for at least 6 months were selected in four Italian centres. QoL was assessed using the World Health Organization Quality of Life questionnaire, and diet satisfaction with the Modification of Diet in Renal Disease satisfaction questionnaire. Comorbidity was assessed by Charlson Comorbidity Index, estimated glomerular filtration rate (eGFR) was calculated by the CKD Epidemiology Collaboration equation and protein intake by Maroni–Mitch formula. Survival was analysed with Kaplan–Meier curves and Cox Proportional Hazard Model.ResultsFour hundred and twenty-two CKD Stages 3–5 patients were enrolled. Over 95% were on moderately restricted diets (0.6 g/kg/day). Compliance was good (protein intake: 0.59 g/kg/day at baseline, 0.72 at the end of follow-up). Median dietary satisfaction was 4 on a 1–5 scale. QoL was not affected by the type of diet, but was influenced by age, comorbidity and setting of care. Two years later, at the end of follow-up, 66.6% of the patients were still on a diet; the main causes of discontinuation were dialysis and death. The dropout rate was low (5.5%); in Cox analysis, patient and renal survival were influenced by age and eGFR, but not by QoL, setting of care or type of diet.ConclusionsLPDs are compatible with high dietary satisfaction and minimal dropout, at least in patients who are able to follow such a diet for at least 6 months.
Serum bicarbonate and cardiovascular events in hypertensive adults: results from the Systolic Blood Pressure Intervention Trial
Authors: Dobre Mirela , Pajewski Nicholas M , Beddhu Srinivasan , Chonchol Michel , Hostetter Thomas H , Li Ping , Rahman Mahboob , Servilla Karen , Weiner Daniel E , Wright Jackson T , Raphael Kalani L ,   for the SPRINT Research Group
Published: July 2019

Abstract

Background
Low serum bicarbonate level is associated with increased mortality, but its role as a predictor of cardiovascular disease (CVD) is unclear. This study evaluates the association between serum bicarbonate concentration and CVD and whether the effect of intensive blood pressure (BP) lowering on CVD outcomes is modified by serum bicarbonate level.

Methods
The Systolic Blood Pressure Intervention Trial (SPRINT) randomized participants to a systolic BP target &lt;120 mmHg (intensive treatment) or &lt;140 mmHg (standard treatment). The primary CVD outcome was a composite of nonfatal myocardial infarction (MI), acute coronary syndrome not resulting in MI, stroke, acute decompensated heart failure and CVD death. Cox proportional hazards models adjusted for demographic, clinical and laboratory characteristics were used to evaluate the association of interest in 9334 SPRINT participants (ClinicalTrials.gov: NCT01206062).

Results
Over a median follow-up of 3.33 years (interquartile range 2.87–3.87 years), 618 (6.6%) participants experienced a primary CVD outcome. Participants with serum bicarbonate &lt;22 mEq/L had a significantly higher risk of the primary CVD outcome (hazard ratio 1.54; 95% confidence interval 1.11–2.14, P = 0.01), compared with participants with bicarbonate 22–26 mEq/L. The magnitude of the CVD risk reduction with intensive BP lowering was similar across bicarbonate strata (P-value for interaction = 0.97).

Conclusions
In hypertensive individuals, serum bicarbonate level &lt;22 mEq/L was associated with an increased CVD risk. The effect of intensive BP lowering on CVD outcomes was not modified by the serum bicarbonate level.
Systemic air embolism as a complication of gastroscopy
Authors: Emir Tulumović , Denijal Tulumović 
Published: July 2019

ABSTRACT
Gastroscopy is a common medical procedure with a low complication rate. Most complications are related to respiratory or cardiovascular incidents, especially in sedated patients. Systemic air embolism secondary to gastroscopy is one of the most serious complications, which has been described in few case reports. We describe an interesting case of gastroscopy-related systemic air embolism in a 73-year-old patient.
Prey preference, environmental tolerances and ichthyotoxicity by the red-tide dinoflagellate Noctiluca scintillans cultured from Tasmanian waters
Authors: Hallegraeff Gustaaf M , Albinsson Maria E , Dowdney Jo , Holmes Angela K , Mansour Maged P , Seger Andreas 
Published: July 2019

AbstractThe large phagotrophic dinoflagellate Noctiluca has become a prominent red tide organism in southeast Australian waters since the 2000s, raising concerns for beach tourism, grazing impacts as well as ichthyotoxicity for finfish aquaculture. Satisfactory culture growth rates (0.23–0.56 per day) were obtained by feeding with small Thalassiosira diatom and Tetraselmis flagellate diets, while optimal growth rates sustained for up to 8 months (0.69 per day) were achieved by feeding in a plankton wheel with the large chain-forming dinoflagellate Gymnodinium catenatum. Noctiluca was highly tolerant towards salinities from 20 to 35 and growth was stimulated by temperatures increasing from 10 to 23°C, which in combination with the key factor of prey abundance explains the incidence in southeast Australia of predominantly summer and spring but occasionally also winter blooms. Fatty acid biomarkers suggest that Tasmanian field populations indiscriminately feed on available diatom and dinoflagellate mixtures. Noctiluca exhibited very limited ichthyotoxicity, and only at the highest cell concentrations of 2 000 000/L (50% reduction in RTgill W1 cell viability). Only the densest red tide surface slicks contained acutely toxic levels of unionized ammonia of 242 to 510 μg/L while inshore slicks generated oxygen concentrations as low as 0–1.5 ppm. Lipid phycotoxins (eicosapentaenoic acid, docosahexaenoic acid) did not appear to contribute to Noctiluca ichthyotoxicity. The fatty acid 20:0 eicosanoic acid may serve as a potential Noctiluca biomarker in marine food webs and sediments.
Top down or bottom up? An observational investigation of improvement in fibromyalgia symptoms following hip and knee replacement
Authors: Schrepf Andrew , Moser Stephanie , Harte Steven E , Basu Neil , Kaplan Chelsea , Kolarik Ellen , Tsodikov Alexander , Brummett Chad M , Clauw Daniel J 
Published: July 2019

Abstract

Objectives
Many patients with osteoarthritis have comorbid symptoms of FM, but it is unknown how these symptoms respond to surgical procedures that address nociceptive input in the periphery, such as total joint replacement. Here we explore differences in clinical characteristics between patients whose FM symptoms do and do not improve following total hip or knee replacement.

Methods
Participants were 150 patients undergoing knee or hip replacement who had a minimum FM survey score of 4 or greater prior to surgery. The top tertile of patients experiencing the most improvement in FM symptoms at month 6 were categorized as ‘Improve’ (n = 48) while the bottom two tertiles were categorized as ‘Worsen/Same’ (n = 102). Baseline symptom characteristics were compared between groups, as well as improvement in overall pain severity, surgical pain severity and physical function at 6 months.

Results
The Worsen/Same group had higher levels of fatigue, depression and surgical site pain at baseline (all P &lt; 0.05). Additionally, they improved less on overall pain severity and physical functioning 6 months after surgery (both P &lt; 0.05).

Conclusion
Most patients derive significant benefit in improvement of comorbid FM symptoms following total joint replacement, but a substantial proportion do not. Understanding the neurobiological basis for these different trajectories may help inform clinical judgment and improve patient care.
Molecular Epidemiology of Ralstonia solanacearum Species Complex Strains Causing Bacterial Wilt of Potato in Uganda
Authors: Abdurahman Abdulwahab , Parker Monica L. , Kreuze Jan , Elphinstone John G. , Struik Paul C. , Kigundu Andrew , Arengo Esther , Sharma Kalpana 
Published: July 2019

Bacterial wilt (BW) caused by the Ralstonia solanacearum species complex (RSSC) is a serious threat to potato production in Uganda. However, little is known about the extent of the disease and the type of the pathogen strains involved. A nationwide survey was conducted to study BW prevalence and incidence in potato, and potato tuber and stem samples of potential alternative hosts were collected for pathogen isolation. DNA was extracted from pure cultures for genetic diversity studies. The pathogen was phylotyped by multiplex PCR; then, a subset of isolates was typed at sequevar level. Isolates of the same sequevar were then haplotyped using multilocus tandem repeat sequence typing (TRST) schemes. BW prevalence and incidence in potato farms were 81.4 and 1.7%, respectively. Three RSSC phylotypes were identified, with the majority of the strains belonging to Phylotype II (80%) followed by Phylotype I (18.5%) and III (1.5%). Phylotype I strains belonged to Sequevar 31, and Phylotype II strains belonged to Sequevar 1. Potato-associated Phylotype II Sequevar 1 strains were more diverse (27 TRST haplotypes) than nonpotato Phylotype I (5 TRST haplotypes). Mapping of TRST haplotypes revealed that three TRST haplotypes of Phylotype II Sequevar 1 strains play an important epidemiological role in BW of potato in Uganda being disseminated via latently infected seed. [Formula: see text] Copyright © 2019 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
PALM-Seq: integrated sequencing of cell-free long RNA and small RNA
Authors: Yang Xi , Wang Taifu , Zhu Sujun , Zeng Juan , Xing Yanru , Zhou Qing , Liu Zhongzhen , Chen Haixiao , Sun Jinghua , Li Liqiang , Xu Jinjin , Geng Chunyu , Xu Xun , Wang Jian , Yang Huanming , Zhu Shida , Chen Fang , Wang Wen-Jing 
Published: July 2019

AbstractCell-free RNA, including both long RNA and small RNA, has been considered important for its biological functions and potential clinical usage, but the major challenge is to effectively sequence them at the same time. Here we present PolyAdenylation Ligation Mediated-Seq (PALM-Seq), an integrated sequencing method for cell-free long and small RNA. Through terminal modification and addition of 3’ polyadenylation and 5’ adaptor, we could get mRNA, long non-coding RNA, microRNA, tRNA, piRNA and other RNAs in a single library. With target RNA depletion, all these RNAs could be sequenced with relatively low depth. Using PALM-Seq, we identified pregnant-related mRNAs, long non-coding RNAs and microRNAs in female plasma. We also applied PALM-Seq to sequence RNA from amniotic fluids, leukocytes and placentas, and could find RNA signatures associated with specific sample type. PALM-Seq provides an integrated, cost-effective and simple method to characterize the landscape of cell-free RNA, and can stimulate further progress in cell-free RNA study and usage.
Genetic evidence suggests relationship between contemporary Bulgarian population and Iron Age steppe dwellers from Pontic-Caspian steppe
Authors: Stamov Svetoslav , Chobanov Todor 
Published: July 2019

AbstractAncient DNA analysis on the ancestry of European populations conducted in the last decade came to the puzzling conclusion that while all contemporary European populations can be best represented as an admixture of 3 ancestral populations –Early European Neolithic farmers (ENF), Western Hunter-Gatherers (WHG) and Ancestral North Eurasians (ANE), contemporary Bulgarians and few other SEE populations can also be represented as an admixture of two groups only – Early European Neolithic farmers and contemporary Caucasian people equally well.If modeled as an admixture of two groups only, the ANE component presented in contemporary Bulgarians would have arrived on the Balkans with hypothetical ANE (Ancestral North Eurasians)-rich Caucasian population.In this paper, we test the hypothesis that increased Caucasian component in contemporary SE Europeans, has been introduced on the Balkans by migrating Iron Age steppe dwellers from Pontic-Caspian steppe. We analyze available DNA datasets from both ancient and contemporary samples and identify a Caucasian signal, carried to Balkan populations by the nomadic dwellers of Early Medieval Saltovo-Mayaki Culture, located on the northern slope of Caucasus Mountains and adjacent steppe regions. We also identify two additional sources of Caucasian admixture in SEE populations, which are not specific to Bulgarian population only. Based on the results from our population genetic analysis we suggest that contemporary Bulgarians are an admixture of ancestral Slavonic groups, rich on locally absorbed EEF DNA and Proto Bulgarians, rich on Caucasian DNA and genetically related to the bearers of the Saltovo-Mayaki Culture from 8-10 century AD.
Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodeling
Authors: Min Elizabeth , Baeyens Nicolas , Hu Rui , Zhuang Zhenwu , Chen Minghao , Huang Billy , Zarkada Georgia , Acheampong Angela , McEntee Kathleen , Simons Michael , Eichmann Anne , Schwartz Martin A. 
Published: July 2019

AbstractRationaleBlood vessel remodeling in response to changes in tissue demand is an important aspect of fitness and is often compromised in vascular disease. Endothelial cell (EC) sensing of fluid shear stress (FSS) governs vessel remodeling to maintain FSS at a specific magnitude or set point in healthy vessels.ObjectiveThe purpose of this study was to understand how shear stress-regulated Smad 2/3 contributes to artery remodeling.Methods and ResultsWe found that shear stress induces Smad 2/3 phosphorylation, nuclear translocation, and gene expression in ECs. Nuclear translocation and gene expression are maximal at low and decrease at high FSS. Reducing flow in the mouse carotid by ligation of branch vessels induces Smad2 nuclear localization in vivo. Activation of Smad 2/3 by FSS requires the Type I TGFβ family receptor Alk5 and the transmembrane protein Neuropilin-1. Flow activation of Smad 2/3 is mediated by increased sensitivity to BMP9 but not BMP10 or TGFβ. By contrast, flow activation of Smad 1/5 is maximal at physiological FSS and requires BMP9 or 10 binding to Alk1 and Endoglin. EC-specific deletion of Alk5 in mice blocks low flow-induced inward remodeling after carotid ligation.ConclusionsTogether, these data elucidate a novel pathway that mediates low flow-induced inward artery remodeling. These results may be relevant to inward remodeling in diseased vessels where Smad 2/3 is activated by pathological stimuli.