bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Silatrane:Molecule‐Based Crystal Composite Solid‐State Electrolyte for All‐Solid‐State Lithium Batteries
Authors: Navarro‐Suárez Adriana M. , Johansson Patrik 
Published: August 2019

AbstractAll‐solid‐state batteries (ASSBs) are promoted as a promising option towards higher energies and power densities as well as drastically reduced safety risks as compared to conventional lithium‐ion batteries (LIBs). Herein, a composite solid‐state electrolyte (SSE) based on two crystalline materials with two distinctly different ion conduction mechanisms, percolation and ion hopping, is reported. By combining a silatrane (SA; here ethoxysilatrane) with a molecule‐based crystal (MBC; here LiTFSI‐TMEDA) the resulting SA : MBC 2 : 1 crystalline composite shows an appreciable ion conductivity of 10−5 S cm−1 at room temperature, and low apparent activation energy, 836 K, for the ion transport. Studies of the overall and local structure show that in the composite the Li+ and TFSI ions are dissociated, and this seems to be mediated by the SA part of the matrix. As a proof‐of‐concept, an ASSB based on this SSE can operate at 50 °C providing up to 105 mAh g−1 during 20 cycles.
Factors affecting sedimentational separation of bacteria from blood
Authors: Pitt William G. , Alizadeh Mahsa , Blanco Rae , Hunter Alex K. , Bledsoe Colin G. , McClellan Daniel S. , Wood Madison E. , Wood Ryan L. , Ravsten Tanner V. , Hickey Caroline L. , Cameron Beard William , Stepan Jacob R. , Carter Alexandra , Husseini Ghaleb A. , Robison Richard A. , Welling Evelyn , Torgesen Rebekah N. , Anderson Clifton M. 
Published: August 2019

AbstractRapid diagnosis of blood infections requires fast and efficient separation of bacteria from blood. We have developed spinning hollow disks that separate bacteria from blood cells via the differences in sedimentation velocities of these particles. Factors affecting separation included the spinning speed and duration, and disk size. These factors were varied in dozens of experiments for which the volume of separated plasma, and the concentration of bacteria and red blood cells (RBCs) in separated plasma were measured. Data were correlated by a parameter of characteristic sedimentation length, which is the distance that an idealized RBC would travel during the entire spin. Results show that characteristic sedimentation length of 20 to 25 mm produces an optimal separation and collection of bacteria in plasma. This corresponds to spinning a 12‐cm‐diameter disk at 3,000 rpm for 13 s. Following the spin, a careful deceleration preserves the separation of cells from plasma and provides a bacterial recovery of about 61 ± 5%.
Impact of stent generation on 2‐year clinical outcomes in ST‐segment elevation myocardial infarction patients with multivessel disease who underwent culprit‐only or multivessel percutaneous coronary intervention
Authors: Kim Yong Hoon , Her Ae‐Young , Jeong Myung Ho , Kim Byeong‐Keuk , Hong Sung‐Jin , Kim Jung‐Sun , Ko Young‐Guk , Choi Donghoon , Hong Myeong‐Ki , Jang Yangsoo 
Published: August 2019

AbstractsBackgroundData concerning the impact of stent generation on long‐term outcomes in ST‐segment elevation myocardial infarction (STEMI) patients with multivessel disease (MVD) who underwent primary percutaneous coronary intervention (PCI) with culprit‐only PCI (C‐PCI) or multivessel PCI (M‐PCI) are limited.MethodsA total of 7,266 patients were separated into the two groups, a C‐PCI (n = 4,901) or M‐PCI group (n = 2,365). The primary endpoint was the occurrence of major adverse cardiac events (MACE) defined as all‐cause death, recurrent myocardial infarction, and any repeat revascularization. The secondary endpoint was the cumulative incidence of stent thrombosis (ST) at 2 years.ResultsThe cumulative incidence of MACE was significantly higher in the bare‐metal stents (BMS) group than the first‐generation (1G)‐drug‐eluting stents (DES) (C‐PCI: adjusted hazard ratio [aHR], 1.940; 95% confidence interval [CI], 1.389–2.709; p < .001; M‐PCI: aHR, 1.544; 95% CI, 1.099–2.074; p = .038), and the second‐generation (2G)‐DES group (C‐PCI: aHR, 2.271; 95% CI, 1.657–3.114; p < .001; M‐PCI: aHR, 2.999; 95% CI, 1.899–4.704; p < .001). In the M‐PCI group, 1G‐DES showed a higher incidence of MACE compared with 2G‐DES (aHR, 1.639; 95% CI, 1.028–2.614; p = .004). The cumulative incidences of ST in the both groups were similar.ConclusionThe cumulative incidence of MACE was the lowest for 2G‐DES, the highest for BMS, and intermediate for 1G‐DES in the STEMI patients with MVD after C‐PCI or M‐PCI. However, cumulative incidence of ST in the two different reperfusion strategy groups was similar regardless of stent generation.
Ruptured saphenous venous graft pseudoaneurysm presenting as a pulsatile chest mass
Authors: Rahman Muhammad Nasir , Khan Bilal K. , Hasan Babar S. 
Published: August 2019

AbstractA 72‐year‐old man with prior history of coronary artery bypass grafting and sternal wire infection presented with non‐ST‐segment elevation myocardial infarction. His coronary angiogram revealed stenosis of the distal left main coronary artery (LMCA) and a pseudoaneurysm of saphenous venous graft (SVG) to right posterior descending artery. Patient developed ventricular fibrillation during admission, and postcardiopulmonary resuscitation, a pulsatile chest mass was observed which was diagnosed with computed tomography as a chest wall collection resulting from rupture of the pseudo‐aneurysm. He underwent percutaneous coronary intervention of the LMCA with drug‐eluting stents followed by successful coil embolization of the SVG pseudoaneurysm. Patient had an uneventful recovery postprocedure.
Patient size parameters to guide use of the Impella device in pediatric patients
Authors: Morray Brian H. , Dimas V. Vivian , McElhinney Doff B. , Puri Kriti , Qureshi Athar M. 
Published: August 2019

AbstractObjectivesTo define patient and ventricular size parameters to guide Impella device (Abiomed, Inc., Danvers, MA) placement for mechanical circulatory support (MCS) in small pediatric patients (10–30 kg).BackgroundThere are few options for MCS in children, and there are no data on minimum patient size requirements for placement of the Impella 2.5 device.MethodsThis was a multicenter study of echocardiographic and magnetic resonance imaging (MRI) derived dimensions of the left ventricle (LV) length and ascending aorta used to define minimum size parameters that are necessary for the placement of the Impella catheter.ResultsData were collected from 44 cardiac MRIs conducted in healthy pediatric patients and 39 echocardiograms performed in pediatric patients with cardiomyopathy prior to surgical ventricular assist device (VAD) placement. The Impella 2.5 catheter is 7.5 cm from the pigtail to the aortic annulus marker, thus requiring an LV apical length of 7.5 cm to allow the device to function in an unconstrained fashion. In the cohort of patients undergoing consideration for VAD placement, a minimum LV length of 7.5 cm corresponded to a height of 122 cm, weight of 23 kg, and body surface area (BSA) of 0.89 m2. In the MRI cohort, this corresponded to a height of 121 cm, weight of 23.9 kg, and BSA of 0.89 m2.ConclusionMCS with Impella devices is feasible in pediatric patients. This study defines anthropomorphic and anatomic measurements to guide providers in patient selection for MCS using the Impella devices.
HPLC and SFC enantioseparation of (±)‐Corey lactone diol: Impact of the amylose tris‐(3,5‐dimethylphenylcarbamate) coating amount on chiral preparation
Authors: Wang Huiying , Wang Qiuhua , Wu Yaling , Cheng Lingping , Zhu Lunan , Zhu Junchen , Ke Yanxiong 
Published: August 2019

AbstractAs an important intermediate of prostaglandins and entecavir, optically pure Corey lactone diol (CLD) has great value in the pharmaceutical industry. In this work, the enantioseparation of (±)‐CLD was evaluated using high‐performance liquid (HPLC) and supercritical fluid chromatography (SFC). In HPLC, the separations of CLD enantiomers on polysaccharide‐based chiral stationary phases with both normal phase and polar organic phase were screened. And the conditions for the enantioseparation were optimized in HPLC and SFC, including the selection of mobile phase, temperature, back‐pressure, and other conditions. More important, it was found that the chiral resolutions were greatly enhanced by the increase of the coating amount of ADMPC (amylose tris‐(3,5‐dimethylphenylcarbamate)) under both HPLC and SFC conditions, which can lead to the increase of the productivity and the decrease of the solvent consumption. The preparations of optically pure CLD were evaluated on a semi‐preparative (2 × 25 cm) column packed with 30% ADMPC‐coated CSP under HPLC and SFC conditions. Preparative performances in terms of kkd are 1.536 kg racemate/kg CSP/day and 1.248 kg racemate/kg CSP/day in HPLC and SFC, respectively.
Second‐Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability
Authors: Šileikytė Justina , Devereaux Jordan , de Jong Jelle , Schiavone Marco , Jones Kristen , Nilsen Aaron , Bernardi Paolo , Forte Michael , Cohen Michael S. 
Published: August 2019

AbstractExcessive mitochondrial matrix Ca2+ and oxidative stress leads to the opening of a high‐conductance channel of the inner mitochondrial membrane referred to as the mitochondrial permeability transition pore (mtPTP). Because mtPTP opening can lead to cell death under diverse pathophysiological conditions, inhibitors of mtPTP are potential therapeutics for various human diseases. High throughput screening efforts led to the identification of a 3‐carboxamide‐5‐phenol‐isoxazole compounds as mtPTP inhibitors. While they showed nanomolar potency against mtPTP, they exhibited poor plasma stability, precluding their use in in vivo studies. Herein, we describe a series of structurally related analogues in which the core isoxazole was replaced with a triazole, which resulted in an improvement in plasma stability. These analogues were readily generated using the copper‐catalyzed “click chemistry”. One analogue, N‐(5‐chloro‐2‐methylphenyl)‐1‐(4‐fluoro‐3‐hydroxyphenyl)‐1H‐1,2,3‐triazole‐4‐carboxamide (TR001), was efficacious in a zebrafish model of muscular dystrophy that results from mtPTP dysfunction whereas the isoxazole isostere had minimal effect.
Overview of Transgenic Mouse Models for Alzheimer's Disease
Authors: Myers Ariana , McGonigle Paul 
Published: August 2019

AbstractThis review describes several transgenic mouse models of Alzheimer's disease (AD), a devastating neurodegenerative disorder that causes progressive cognitive decline and is diagnosed postmortem by the presence of extracellular amyloid‐β (Aβ) plaques and intraneuronal tau neurofibrillary tangles in the cerebral cortex. Currently there is no intervention that cures, prevents, or even slows disease progression. Its complex etiology and pathology pose significant challenges for animal model development, and there is no single model that faithfully recapitulates both the pathological aspects and behavioral phenotypes of AD. Nearly 200 transgenic rodent models of AD have been generated primarily based on mutations linked to Aβ protein misprocessing in the familial form of the disease. More recent models incorporate mutations in tau protein, as well as mutations associated with the sporadic form of the disease. The salient features, strengths, limitations, and key differentiators for the most commonly used and best characterized of these models are considered here. While the translational utility of many of these models to assess the potential of novel therapeutics is in dispute, knowledge of the different models available and a detailed understanding of their features can aid in the selection of the optimal model to explore disease mechanisms or evaluate candidate medications. We comment on the predictive utility of these models considering recent clinical trial failures and discuss trends and future directions in the development of models for AD based on the plethora of clinical data that have been generated over the last decade. © 2019 by John Wiley & Sons, Inc.
Gold Recycling at Laboratory Scale: From Nanowaste to Nanospheres
Authors: Oestreicher Víctor , García Carolina S. , Soler‐Illia Galo J. A. A. , Angelomé Paula C. 
Published: August 2019

AbstractThe market for products based on nanotechnology, and with it the use of nanomaterials and the generation of nanowaste, increases day by day. Among the vast variety of nanomaterials available, gold nanoparticles (AuNPs) are among the most studied and applied in commercial products. This current situation requires both the development of recovery methods to reduce the amount of nanowaste produced, and new synthetic methods that allow the reuse of recovered gold for new nanomaterial production, keeping in mind both economical and ecological considerations. In this work, a methodology to recover gold from aqueous laboratory nanowaste and transform it into an aqueous HAuCl4 solution was developed, using extremely simple procedures and readily available chemical reagents (NaCl, HCl, H2O2) and allowing the recovery of more than 99 % of the original gold. The experiments were performed by using both simulated and real laboratory nanowastes, and practically the same results were obtained. Moreover, the subsequent use of the obtained aqueous HAuCl4 solution from the recovered gold to produce spherical AuNPs through a seed‐mediated approach was demonstrated. Thus, this work presents for the first time a complete recycling cycle from nanowaste to the reagent and back to the nanomaterial.
OMIP‐061: 20‐Color Flow Cytometry Panel for High‐Dimensional Characterization of Murine Antigen‐Presenting Cells
Authors: DiPiazza Anthony T. , Hill Juliane P. , Graham Barney S. , Ruckwardt Tracy J. 
Published: August 2019

AbstractThis 20‐color flow cytometry panel was designed to resolve the cellular heterogeneity of antigen‐presenting cells and was optimized for lymph node tissue. Reagents were carefully selected and optimized for identification of B cells (B220), neutrophils (Ly6G), monocytes and macrophages (Ly6C, CD169, F4/80), and dendritic cells (XCR1, CD172a, CD11c, I‐A/I‐E, CD24, CD64, pDCA‐1, CD103, CD11b). Inclusion of additional functional markers involved in cell migration (CCR7), co‐stimulation (CD80), and adhesion (ICAM‐1) enabled further phenotypic characterization. Finally, this panel has been tested and is compatible with fluorescently labeled antigens such as Alexa Fluor 488 (Ax488) for the study of antigen‐bearing cells in vivo. Published 2019. This article is a U.S. Government work and is in the public domain in the USA.
The Quantification of Minimal Residual Disease Pre‐ and Post‐Unmanipulated Haploidentical Allograft by Multiparameter Flow Cytometry in Pediatric Acute Lymphoblastic Leukemia
Authors: Wang Xin‐Yu , Fan Qiao‐Zhen , Xu Lan‐Ping , Wang Yu , Zhang Xiao‐Hui , Chen Huan , Chen Yu‐Hong , Wang Feng‐Rong , Han Wei , Sun Yu‐Qian , Yan Chen‐Hua , Tang Fei‐Fei , Liu Yan‐Rong , Mo Xiao‐Dong , Liu Kai‐Yan , Huang Xiao‐Jun , Chang Ying‐Jun 
Published: August 2019

BackgroundThis study aimed to determine the impact of the pre‐ and post‐minimal residual disease (MRD) status as well as the peri‐transplant MRD kinetics on clinical outcomes in pediatric ALL patients who received haploidentical allografts.MethodsA retrospective study (n = 166) was performed. MRD was determined using multiparameter flow cytometry.ResultsPediatric ALL patients with pre‐MRDneg had a lower cumulative incidences of relapse (CIR) compared to those with pre‐MRDpos (19.7% vs. 41.2%, P = 0.009). Compared to post‐MRDneg group, patients with post‐MRDpos experienced higher CIR (81.0% vs. 15.9%, P < 0.001), inferior LFS (14.3% vs. 66.9%, P < 0.001) and OS (19.1% vs. 66.9%, P < 0.001). In regard to peri‐MRD kinetics, compared with the MRD‐decreasing group and MRDneg/MRDneg group, MRD‐increasing group had higher CIR, lower probabilities of LFS and OS (P < 0.001). Compared to pre‐MRDneg/post‐MRDneg group, a higher CIR was found in the pre‐MRDpos/post‐MRDpos group (66.7% vs. 12.5%, P < 0.001), pre‐MRDpos/post‐MRDneg group (32.0% vs. 12.5%, P = 0.016), and pre‐MRDneg/post‐MRDpos group (91.7% vs. 12.5%, P < 0.001). A lower incidence of LFS and OS were found in pre‐MRDpos/post‐MRDpos group and pre‐MRDneg/post‐MRDpos group than in pre‐MRDneg/post‐MRDneg group (P < 0.05). Multivariate analyses confirmed the association of pre‐MRD status, post‐MRD status, and peri‐MRD kinetics with outcomes (P < 0.05).ConclusionsThe results indicate that, in the pediatric ALL subgroup, not only pre‐MRD status or post‐MRD status but also peri‐SCT MRD dynamics, were associated with an increased CIR after haploidentical allografts. Patients are put into different risk group based on MRD kinetics versus single time MRD status. © 2019 International Clinical Cytometry Society
Identity‐and‐data privacy forward security public auditing protocol in the standard model
Authors: Zhang Jianhong , Jiang Zhengtao 
Published: August 2019

SummaryTo ensure the intactness of the stored data in cloud, numerous data public auditing mechanisms have been presented. However, most of these existing solutions suffer from several flaws: (a) identity privacy and data privacy of data owner are inevitably revealed to the auditor in the auditing process; (b) the existing public auditing mechanisms with resisting key exposure are only proved in the random oracle model. To address the problems above, in this paper, we propose an achieving identity‐and‐data privacy public auditing protocol with forward security in the standard model by incorporating knowledge proof signature, ring signature, and forward security technique. And then, we formalize the security model of forward security and anonymity of identity, in which the adversary is allowed to query private keys of some ring members. It can provide stronger security. Thus, our proposed scheme can not only achieve data owner's identity privacy and data privacy but also provide forward security for data owner's secret key. To the best of our knowledge, it is the first preserving privacy of identity‐and‐data public auditing scheme with forward security that is provably secure in the standard model. The security of the scheme is related to the computational Diffie–Hellman (CDH) problem and the subgroup decision problem. Finally, our scheme is simulatively tested; experimental results demonstrate that our mechanism is very efficient in terms of overall performance.
A pessimistic method in web service composition by view on execution states
Authors: Alizadeh Roohallah 
Published: August 2019

SummaryThe application of web services in implementing enterprise workflows has recently been prevalent. In this regard, one of the important challenges is to create web service compositions that satisfy quality properties. One of the properties is rollback cost that it must be paid for resolving effects of a web service that its execution is completed. In the previous methods, a web service was evaluated based on whether failure or successful execution state and other two states (in the middle of execution and waiting for execution) were neglected. By considering these two states, it is possible to prevent imposition in a web service rollback cost or reduce it if needed to finally provide the possibility to decrease a web service average rollback cost. Two mentioned states are related to execution time, and it is clear that the proposed solution should be related to execution time.According to implemented tests, the method not only reduces rollback cost but also causes the execution time to reduce. The reduction in execution time parameter is due to necessary waiting for a web service completion before providing the ability to rollback it in conventional methods, but in the method, it is possible to rollback web service before execution completion and waiting for completion is not mandatory.
Safety, Tolerability and efficacy of Rapid Optimization, helped by NT‐proBNP and GDF‐15, of Heart Failure therapies (STRONG‐HF): rationale and design for a multicentre, randomized, parallel‐group study
Authors: Kimmoun Antoine , Cotter Gad , Davison Beth , Takagi Koji , Addad Faouzi , Celutkiene Jelena , Chioncel Ovidiu , Solal Alain Cohen , Diaz Rafael , Damasceno Albertino , Duengen Hans‐Dirk , Filippatos Gerasimos , Goncalvesova Eva , Merai Imad , Metra Marco , Ponikowski Piotr , Privalov Dmitry , Sliwa Karen , Sani Mahmoud Umar , Voors Adriaan A. , Shogenov Zaur , Mebazaa Alexandre 
Published: August 2019

AimsPatients admitted for acute heart failure (HF) are at high risk of readmission and death, especially in the 90 days following discharge. We aimed to assess the safety and efficacy of early optimization of oral HF therapy with beta‐blockers (BB), angiotensin‐converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) or angiotensin receptor–neprilysin inhibitors (ARNi), and mineralocorticoid receptor antagonists (MRA) on 90‐day clinical outcomes in patients admitted for acute HF.MethodsIn a multicentre, randomized, open‐label, parallel‐group study, a total of 900 patients will be randomized in a 1:1 ratio to either ‘usual care’ or ‘high‐intensity care’. Patients enrolled in the usual care arm will be discharged and managed according to usual clinical practice at the site. In the high‐intensity care arm, doses of oral HF medications – including a BB, ACEi or ARB, and MRA – will be up‐titrated to 50% of recommended doses before discharge and to 100% of recommended doses within 2 weeks of discharge. Up‐titration will be delayed if the patients develop worseningsymptoms and signs of congestion, hyperkalaemia, hypotension, bradycardia, worsening of renal function or significant increase in N‐terminal pro‐B‐type natriuretic peptide between visits. The primary endpoint is 90‐day all‐cause mortality or HF readmission.ConclusionsSTRONG‐HF is the first study to assess whether rapid up‐titration of evidence‐based guideline‐recommended therapies with close follow‐up in a large cohort of patients discharged from an acute HF admission is safe and can affect adverse outcomes during the first 90 days after discharge.Clinical Trial Registration: ClinicalTrials.gov Identifier NCT03412201.
Experimental studies of furfural production from water hyacinth (Eichhornia Crassipes)
Authors: Poomsawat Wijittra , Tsalidis George , Tsekos Christos , de Jong Wiebren 
Published: August 2019

AbstractFurfural is a very promising product of lignocellulosic biomass‐based biorefineries and has the potential to become a useful resource for further conversion and utilization. Aquatic plants show an enormous potential as feedstock since they do not compete for land use, and they require minimal water consumption in a biorefinery concept due to their very high water content. This work is focused on experimental studies of furfural production from water hyacinth (Eichhornia crassipes) by means of aqueous, acid‐catalyzed dehydration. The temperature range of the process, and the acid and seawater presence were chosen based on the previous relevant studies. The aim of the study was to determine whether water hyacinth is suitable for furfural production. The experiments were performed between 160°C and 200°C with a water hyacinth concentration of 2 wt%. The results suggest that the effects of acid catalyst presence on biomass dehydration are similar to the case of pure pentose dehydration. Furthermore, the addition of seawater did not have a positive catalytic effect in terms of the furfural yield. The maximum yield was 53.2 mol% based on the C5 sugar content in the original biomass. The furfural yield of 7.9 wt% of water hyacinth input was comparable to the yield of feedstocks such as corn cob, bagasse, and oat's residue and higher than the cases of rice straw or hulls. Thanks to the comparatively high pentose potential, water hyacinth shows promising results as a candidate feedstock for furfural production. A certain variability of pentosan should be taken into account, as the chemical composition of the plant depends on the source and harvesting seasons.