bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Implementation of Training and Development Program: A Study Case at PT Bank Negara Indonesia Branch
Authors: Ayal Rosalin , Isanawikrama Isanawikrama , Buana Yud 
Published: August 2018

This research discussed the implementation of training and development programs in an organization. Undertaken deep interview as a method, it was reviewing the training and development programs of PT Bank Negara Indonesia Cabang Pasar Klewer di Surakarta (BNI CPKS) that covered the nature of training and development programs, training and development process, and behavioral aspects of the process. This research used the qualitative approach, consisted of literature theories and previous researches also explored analysis from the author by deep interview to 15 employees including management level of existing company’s unit/departments. The analysis was undertaken through collecting data first, presenting the training and development programs and then comparing them with the relevant theories. By having a well-implemented training and development programs, it was hoped that the effort would result from the accomplishment of short-term, midterm, and long-term goals of the company. As the conclusion, the work of training and development programs at BNI CPKS in overall is considered poor. The Human Resource Management, which is under administration level has no right to run its main responsibilities, which are to coordinate and arrange company’s training and development programs. Almost process of training and development program is set by central (Jakarta) or regional (Semarang) office. In addition, the behavioral aspect negatively affects to the training and development programs of BNI CPKS, inducing all management levels to participate the training and developments programs as a formality.
Coagulation performance of cucurbit[8]uril for the removal of azo dyes: effect of solution chemistry and coagulant dose
Authors: Wang Wendong , Chen Zhiwen , Wu Kun , Liu Zongkuan , Yang Shengjiong , Yang Qin , Dzakpasu Mawuli 
Published: August 2018

Abstract
Dye wastewater has attracted significant attention because of its wide pH range and high content of color. In this work, the coagulation performances of cucurbit[8]uril for the removal of color from acid red 1 (AR1), orange II (OII), and Congo red (CR) dye wastewaters were investigated. Experimental results showed that color removal rates of greater than 95% for AR1, OII and CR were achieved at pH 6.0, when the dosage of cucurbit[8]uril was 1.51, 3.01 and 0.38 mmol·L−1, respectively. Under identical conditions, the color removal efficiencies of AR1 and CR were higher than OII, due to the larger molecular weights and more active hydroxyl and amino groups. Moreover, steady increases in AR1, OII and CR removal rates were recorded with increasing ionic strength. Such increases may be related to the reduction in thickness of the surface solvent membrane surrounding the dye colloids at high ionic strengths. Furthermore, Fourier transform infrared spectra demonstrated that no new bonds or functional groups were formed during coagulation, which indicates that the removal of AR1, OII and CR was primarily a physical process. The hydrogen bonds and inclusion complexes formed between cucurbit[8]uril and AR1, OII and CR contributed to the removal of color in coagulation predominantly.
Sudah efektifkah kebijakan kawasan tanpa rokok di Indonesia?
Authors: Amaliah Nur Aeni 
Published: August 2018

Tujuan: Era desentralisasi menjadikan pemerintah lokal memiliki wewenang untuk mencegah dampak negatif dari konsumsi tembakau. Sekitar 30% kabupaten/kota di Indonesia memiliki perda KTR, namun efektifitas kebijakan tersebut dalam menurunkan prevalensi merokok perlu diteliti. Isi kebijakan KTR hanya membatasi area merokok dan iklan rokok di wilayah yang sebagian besar sebenarnya ada di perkotaan. Bagaimana dengan kebijakan di perdesaan?. Isi kebijakan tiap daerah berbeda-beda yang dapat menimbulkan kesenjangan peraturan antar daerah. Indonesia belum meratifikasi tembakau dan undang-undang tentang pertembakauan belum disahkan pemerintah. Konten: Tidak ada perbedaan jumlah perokok remaja pada daerah dengan dan tanpa KTR. Contohnya di DKI Jakarta yang memiliki regulasi KTR namun kenyataannya dalam pelaksanaannya tidak selalu dipatuhi. Kebijakan KTR yang ada di daerah tidak memiliki dampak pengurangan merokok pada usia remaja. Kawasan yang telah ditentukan dalam kebijakan KTR merupakan tempat-tempat yang ada di perkotaan misalnya kantor, sekolah, restoran, pasar dan rumah sakit, sedangkan di pedesaan hampir tidak ada tempat pelarangan merokok. Berdasarkan hasil Riskesdas 2013, orang yang merokok setiap hari sebagian besar (25.5%) tinggal di daerah perdesaan. Simpulan: Kebijakan KTR di Indonesia belum efektif. Pemerintah daerah yang tidak menggantungkan sumber pendapatannya dari tembakau dapat lebih tegas peraturannya. Pada daerah tersebut, kebijakan untuk mengurangi prevalensi perokok selain KTR sebaiknya ditambah pembatasan penjualan rokok di warung-warung dan sales penjual rokok di desa-desa. Larangan merokok di dalam rumah belum ada dalam Perda KTR, ini dapat menjangkau perkotaan maupun perdesaan. Fungsi pengawasan harus dicantumkan dengan jelas dalam perda KTR.
Berat lahir bayi beserta determinannya sebagai faktor risiko kematian bayi di Indonesia: analisis lanjut SDKI 2012
Authors: Farida Ida 
Published: August 2018

Angka Kematian Bayi (AKB) di Indonesia masih tinggi disebabkan kejadian bayi berat lahir rendah (BBLR) yang tinggi. Bayi merupakan tahap awal perjalanan hidup manusia penerus bangsa. Bayi merupakan investasi sumber daya manusia (SDM) untuk masa yang akan datang. Kualitas kehidupan bayi secara tidak langsung akan menjadi estimasi kualitas kehidupan bangsa di masa yang akan datang. Penelitian ini bertujuan untuk mengetahui pengaruh berat lahir terhadap kelangsungan hidup bayi. Penelitian dengan desain studi kohort retrospektif ini menggunakan sumber data sekunder Survei Demografi Kesehatan Indonesia (SDKI) tahun 2012 dengan menggunakan model probit untuk analisis. Hasil : Penelitian ini menemukan bahwa yang berpengaruh signifikan secara positif dalam penentuan BBLR adalah jarak kelahiran, umur ibu ketika melahirkan, komplikasi kehamilan, paritas (banyak kelahiran), kualitas dan kuantitas antenatal care (ANC), sosial ekonomi keluarga dan daerah tempat tinggal dengan penjelasan pengaruh dari masing-masing variabel tersebut terhadap presentase probabilitas bayi lahir dengan tidak BBLR sebagai berikut : jarak kelahiran lebih dari dua tahun memiliki sebesar 6,21% usia melahirkan ideal sebesar 2,98% tidak adanya komplikasi selama kehamilan sebesar 6,46% jumlah anak kurang dari tiga sebesar 5,1% kualitas ANC ketika hamil sebesar 13,63% tingkat sosial ekonominya lebih baik sebesar 13,25% tempat tinggal di kota sebesar 9,04%Sedangkan yang tidak signifikan dalam mempengaruhi adalah jenis kelamin bayi. Kesimpulan: Kelangsungan hidup bayi dapat ditentukan melalui berat bayi ketika dilahirkan. Terdapat beberapa karakteristik yang mempengaruhi hasil dari berat bayi lahir tersebut. Karakteristik tersebut antara lain adalah karakteristik bayi, ibu, pelayanan kesehatan dan karakteristik lingkungan. Karakteristik ibu menjadi faktor yang paling signifikan dalam menentukan berat bayi lahir tersebut, dimana intervensi dapat dilakukan lebih utama kepada ibu yang dapat secara siginifikan menurunkan angka AKB.
Observasi Klinik Pemberian Aroma Pandan Wangi Terhadap Tekanan Darah Pasien Hipertensi
Authors: Priastomo Mukti , Sau Riska Putri Patila , Fadraersada Jaka 
Published: August 2018

Daun pandan wangi memiliki aroma khas yang berasal dari minyak atsiri. Kandungan minyak atsiri pada daun pandan wangi terdiri dari 6–42% hidrokarbon sesquiterpen dan 6% monoterpen linalool dan 10% senyawa aromatik berupa 2-acetyl-1 pyrroline. Senyawa minyak atsiri daun pandan wangi memberikan efek relaksasi pada pasien hipertensi. Penelitian ini bertujuan untuk melihat karakteristik, pola pengobatan dan efek dari pemberian aroma pandan wangi terhadap tekanan darah pasien hipertensi di Puskesmas Sempaja Samarinda. Metode penelitian yang digunakan adalah metode eksperimental quasy. Prosedur dalam penelitian ini menggunakan pengukuran awal dan pengukuran akhir. Pengumpulan data karakteristik dilakukan secara retrospektif dan didapatkan persentase tertinggi dari jenis kelamin adalah perempuan sebanyak 55,36%. Usia dengan persentase tertinggi adalah usia pertengahan sebanyak 57,14%. Obat yang paling banyak dikonsumsi adalah amlodipin sebanyak 75,45%. Hasil analisis dari pemberian aroma pandan wangi sebelum dan setelah pemberian aroma terjadi penurunan pada tekanan sistol sebanyak 7,5 mmHg, pada tekanan diastol sebanyak 1,1 mmHg dan penurunan pada denyut jantung sebanyak 3,1. Kesimpulan dari penelitian ini adalah perempuan lebih banyak menderita hipertensi, usia yang paling tinggi terkena hipertensi adalah usia pertengahan dan obat yang paling banyak dikonsumsi adalah amlodipin. Hasil dari intervensi aroma dari pandan wangi dapat menurunkan tekanan darah dan denyut jantung.
Pengaruh Pemberian Ibuprofen Preoperatif Terhadap Sebaran Sel Radang Kronis Pada Proses Penyembuhan Luka Pasca Pencabutan Gigi
Authors: Alviony Fanny Marisca , Hermanto Eddy , W Widaningsih 
Published: August 2018

<strong><em>Latar Belakang:</em></strong><em> Luka adalah rusaknya sebagian jaringan tubuh yang disebabkan oleh agen kuman, parasit, jamur, trauma benda tajam, perubahan suhu, zat kimia, sengatan listrik. Fase inflamasi pada proses penyembuhan luka sangat berperan penting. Pada inflamasi kronis terdapat infiltrasi sebaran sel radang kronis yaitu makrofag, limfosit, sel plasma, eosinofil, sel mast, basofil yang disertai dengan proliferasi pembuluh darah serta fibrosis. Ibuprofen merupakan obat antiinflamasi dan analgesik yang umum diberikan setelah tindakan pencabutan gigi. <strong>Tujuan:</strong> Penelitian ini bertujuan untuk melihat pengaruh pemberian ibuprofen preoperatif terhadap sebaran sel radang kronis pada proses penyembuhan luka pasca pencabutan gigi. <strong>Bahan dan Metode: </strong>Unit eksperimental yang digunakan adalah<strong> </strong>20 ekor tikus Wistar jantan dan dibagi menjadi 2 kelompok, Kelompok 1 (NaCMC 0,2%), Kelompok 2 (Ibuprofen 7,2mg/200grBB). NaCMC 0,2% untuk kelompok K dan Ibuprofen untuk kelompok X diberikan 1 jam sebelum pencabutan gigi kemudian gigi insisivus kiri bawah tikus dilakukan pencabutan. Soket kemudian dijahit dan dibiarkan sampai 7 hari. Data yang diperoleh dianalisis dengan uji Chi-Square. <strong>Hasil: </strong>Uji Chi-Square<strong> </strong>menunjukkan ada perbedaan yang signifikan antar kelompok K dan X p=0,003 (p&lt;0,05). <strong>Simpulan: </strong>Pemberian ibuprofen preoperatif menurunkan sebaran sel radang kronis pada proses penyembuhan luka pasca pencabutan gigi.</em>
Bioviabilitas Hidroksiapatit Ekstrak Cangkang Kerang Darah (Anadara granosa) Terhadap Sel Punca Mesenkimal Sebagai Bahan Graft Tulang Alveol
Authors: Nastiti Arlita Dewi , Widyastuti W , Laihad Fanny M 
Published: August 2018

<p><strong>Latar belakang: </strong>Salah satu bahan pengisi suatu defek tulang dapat berupa hidroksiapatit. Hidroksiapatit dapat diperoleh dari ekstrak cangkang kerang darah <em>Anadara granosa</em> yang memiliki kandungan kalsium yang tinggi. Kandungan mineral tersebut dapat dijadikan sebagai bahan pengisi tulang untuk <em>bone grafting</em>. Namun, bahan tersebut belum diketahui bioviabilitasnya terhadap jaringan periodontal sehingga perlu dijui bioviabilitasnya. Pengujian bioviabilitas ini menggunakan sel punca mesenkimal karena sel punca mesenkimal dapat berdiferensiasi menjadi jaringan periodontal. <strong>Tujuan</strong>: Untuk mengetahui bioviabilitas ekstrak cangkang kerang darah Anadara granosa terhadap sel punca mesenkimal. <strong>Bahan dan Metode</strong>: Penelitian ini dilakukan menggunakan rancangan <em>post </em><em>o</em><em>nly control group design</em>. Stem sel mesenkim dalam 96 sumuran dibagi menjadi kelompok kontrol sel (n=7), kontrol media (n=7), dan perlakuan (n=7). Kelompok perlakuan diberi berbagai dosis ekstrak cangkang kerang darah <em>Anadara granosa</em> dengan konsentrasi 54 mg/ml, 27 mg/ml, 13,5 mg/ml dan 6,75 mg/ml. Sel punca mesenkimal tersebut diinkubasi selama 24 jam sebelum dan sesudah perlakuan. Setelah diberi MTT, <em>optical density </em>dibaca dengan <em>ELISA reader </em>dan dihitung persentase viabilitasnya. Data viabilitas sel tersebut dianalisa dengan uji statistik <em>Kruskall-Wallis, Mann-Whitney</em>. <strong>Hasil</strong>: Dari menunjukan hasil bahwa terjadi peningkatan viabilitas sel terhadap ekstrak cangkang kerang darah <em>Anadara granosa</em>. Viabilitas sel meningkat dimulai dari kelompok perlakuan konsentrasi 54 mg/ml (23,67%), 27 mg/ml (57,43%), 13,5 mg/ml (68,87%), 6,75 mg/ml (81,92%). Viabilitas sel tertinggi pada konsentrasi 6,75 mg/ml (81,92%). <strong>Kesimpulan</strong>: Ekstrak cangkang kerang darah <em>Anadara granosa</em> memiliki bioviabilitas sel paling tinggi pada konsentrasi 6,75 mg/ml dan bioviabilitas sel yang paling rendah pada konsentrasi 54 mg/ml.</p><p> </p>
EFFICACY OF REFLEXOTHERAPY IN COMPLEX REHABILITATION IN CHILDREN WITH CEREBRAL PALSY BY ASSESSING (of life quality)
Authors: Liskevich І. I. 
Published: August 2018

The article analyzes the reflexology techniques that are used in the system of rehabilitation in children with cerebral palsy and comparative effectiveness in 72 children who were on treatment at the center of early medical and social rehabilitation for children with organic damage of the central nervous system. The main clinical effects are shown and the frequency of adverse reactions of reflexotherapy in this category of patients is analyzed.
Neurodegenerative and Fatiguing Illnesses, Infections and Mitochondrial Dysfunction: Use of Natural Supplements to Improve Mitochondrial Function.
Authors: Nicolson Garth L. , Settineri Robert , Ellithorpe Rita R. 
Published: August 2018

Background: Many chronic diseases and illnesses are associated with one or more chronic infections, dysfunction of mitochondria and reduced production of ATP. This results in fatigue and other symptoms that occur in most if not all chronic conditions and diseases.Methods: This is a review of the published literature on chronic infections in neurodegenerative diseases and fatiguing illnesses that are also typified by mitochondrial dysfunction. This contribution also reviews the use of natural supplements to enhance mitochondrial function and reduce the effects of chronic infections to improve overall function in various chronic illnesses.Results: Mitochondrial function can be enhanced by the use of various natural supplements, notably Lipid Replacement Therapy (LRT) using glyerolphospholipids and other mitochondrial supplements. In various chronic illnesses that are characterized by the presence of chronic infections, such as intracellular bacteria (Mycoplasma, Borrelia, Chlamydia and other infections) and viruses, LRT has proven useful in multiple clinical trials. For example, in clinical studies on chronic fatigue syndrome, fibromyalgia syndrome and other chronic fatiguing illnesses where a large majority of patients have chronic infections, LRT significantly reduced fatigue by 35-43% in different clinical trials and increased mitochondrial function. In clinical trials on patients with multiple intracellular bacterial infections and intractable fatigue LRT plus other mitochondrial supplements significantly decreased fatigue and improved mood and cognition.Conclusions: LRT formulations designed to improve mitochondrial function appear to be useful as non-toxic dietary supplements for reducing fatigue and restoring mitochondrial and other cellular membrane functions in patients with chronic illnesses and multiple chronic infections.Key words: Neurodegenerative and fatiguing illnesses, infections and mitochondrial dysfunction, ATP, Lipid Replacement Therapy (LRT)
Hepatotropic, antioxidant and antitoxic action of amaranth oil
Authors: Nikolaevsky V. A. , Martirosyan D. M. , Muzalevskaya E. N. , Miroshnichenko L. A. , Zoloedov V. I. 
Published: August 2018

Background: It is our opinion that amaranth seed oil’s properties merit further study due to their high quantity of squalene. Squalene has been shown to have antitoxic, antioxidant, and hepatotropic properties. The liver is one of the most important organs in the human body, and as a filtering organ, it is subjected to many toxic compounds and free radicals. Thus, protecting the liver with an antioxidant and antitoxic compound could offer significant benefits.Objective: In the present study we have evaluated the antitoxic, antioxidant, and hepatotropic (hepatoprotective) effects of amaranth oil acquired via a patented pressing method. Rats were treated with amaranth oil, a comparative compound, or a control compound and then subjected to various toxic, oxidizing, and other compounds in order to examine amaranth oil’s effects. Results: Amaranth oil was found to have a positive and dose-dependent effect both in vivo and in vitro. Amaranth oil’s hepatoprotective activity was confirmed by both biological and morphological examination. This study suggests that amaranth oil acts to prevent and reduce CT damage in liver tissue. This was especially the case in doses of 300 mg/kg, proved both by normalization of hepatic ferments-markers indexes and morphological examinations.Conclusion: The amaranth oil acquired via a patented pressing method possesses antitoxic and antioxidant activity. In this connection, the amaranth oil can be recommended for prophylaxis of toxic and drug-induced liver lesions and as a component of the functional food and dietetics of various diseases.Keywords: antioxidant activity, free-radical oxidation, hypoxia, erythrocytes hemolysis, squalene, amaranth oil, hepatoprotector, hexenalum sleep, toxic hepatitis
The High-velocity Stars in the Local Stellar Halo from Gaia and LAMOST
Authors: Du Cuihua , Li Hefan , Liu Shuai , Donlon Thomas , Newberg Heidi Jo 
Published: August 2018

Abstract
Based on the first Gaia data release and spectroscopy from the LAMOST Data Release 4, we study the kinematics and chemistry of the local halo stars. The halo stars are identified kinematically with a relative speed of at least 220 km s−1 with respect to the local standard of rest. In total, 436 halo stars are identified. From this halo sample, 16 high-velocity (HiVel) stars are identified. We studied the metallicity and [α/Fe] distribution of these HiVel stars. Though most HiVel stars are metal-poor, there are several stars that have metallicities above −0.5 dex. To understand the origin of high-velocity stars, we evolve the trajectory of the star backward along the orbit in our adopted Galaxy potential model to determine the orbital parameters and assess whether the star could have originated in the Galactic center (GC). We found that some high-velocity stars could have originated from the GC, but other stars were probably kicked up from the Galactic disk.
DAVs: Red Edge and Outbursts
Authors: Luan Jing , Goldreich Peter 
Published: August 2018

Abstract
As established by photometric surveys, white dwarfs with hydrogen atmospheres and surface gravity, log(g) ≈ 8.0 pulsate as they cool across the temperature range of 12,500 K ≳ T
eff ≳ 10,800 K. Known as DAVs or ZZ Ceti stars, their oscillations are attributed to gravity modes excited by convective driving. Overstability requires convective driving to exceed radiative damping. Previous works have demonstrated that ω ≳ max(τ

c

−1, L

ℓ,b
) is a necessary and sufficient condition for overstability. Here τ

c
and L

ℓ,b
are the effective thermal timescale and Lamb frequency at the base of the surface convection zone. Below the observational red edge, L

ℓ,b
≫ τ

c

−1, so overstable modes all have ωτ

c
≫ 1. Consequently, their photometric amplitudes are reduced by that large factor rendering them difficult to detect. Although proposed previously, the condition ω ≳ L

ℓ,b
has not been clearly interpreted. We show that modes with ω < L

ℓ,b
suffer enhanced radiative damping that exceeds convective driving rendering them damped. A quasi-adiabatic analysis is adequate to account for this enhancement. Although this approximation is only marginally valid at the red edge, it becomes increasingly accurate toward both higher and lower

. Recently, Kepler discovered a number of cool DAVs that exhibit sporadic flux outbursts. Typical outbursts last several hours, are separated by days, and release ∼1033–1034 erg. We attribute outbursts to limit cycles arising from sufficiently resonant 3-mode couplings between overstable parent modes and pairs of radiatively damped daughter modes. Limit cycles account for the durations and energies of outbursts and their prevalence near the red edge of the DAV instability strip.
Impaired Development and Expansion of Germinal Center Follicular Th Cells in Simian Immunodeficiency Virus–Infected Neonatal Macaques
Authors: Xu Huanbin , Ziani Widade , Shao Jiasheng , Doyle-Meyers Lara A. , Russell-Lodrigue Kasi E. , Ratterree Marion S. , Veazey Ronald S. , Wang Xiaolei 
Published: August 2018

Abstract
Germinal center (GC) CD4+ follicular Th (Tfh) cells are critical for cognate B cell help in humoral immune responses to pathogenic infections. Although Tfh cells are expanded or depleted in HIV/SIV-infected adults, the effects of pediatric HIV/SIV infection on Tfh cells remain unclear. In this study, we examined changes in lymphoid follicle formation in lymph nodes focusing on GC Tfh cells, B cell development, and differentiation in SIV-infected neonatal rhesus macaques (Macaca mulatta) compared with age-matched cohorts. Our data showed that follicles and GCs of normal infants rapidly formed in the first few weeks of age, in parallel with increasing GC Tfh cells in various lymphoid tissues. In contrast, GC development and GC Tfh cells were markedly impaired in SIV-infected infants. There was a very low frequency of GC Tfh cells throughout SIV infection in neonates and subsequent infants, accompanied by high viremia, reduction of B cell proliferation/resting memory B cells, and displayed proinflammatory unresponsiveness. These findings indicate neonatal HIV/SIV infection compromises the development of GC Tfh cells, likely contributing to ineffective Ab responses, high viremia, and eventually rapid disease progression to AIDS.
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy
Authors: Spangler Jamie B. , Trotta Eleonora , Tomala Jakub , Peck Ariana , Young Tracy A. , Savvides Christina S. , Silveria Stephanie , Votavova Petra , Salafsky Joshua , Pande Vijay S. , Kovar Marek , Bluestone Jeffrey A. , Garcia K. Christopher 
Published: August 2018

Abstract
IL-2 has been used to treat diseases ranging from cancer to autoimmune disorders, but its concurrent immunostimulatory and immunosuppressive effects hinder efficacy. IL-2 orchestrates immune cell function through activation of a high-affinity heterotrimeric receptor (composed of IL-2Rα, IL-2Rβ, and common γ [γc]). IL-2Rα, which is highly expressed on regulatory T (TReg) cells, regulates IL-2 sensitivity. Previous studies have shown that complexation of IL-2 with the JES6-1 Ab preferentially biases cytokine activity toward TReg cells through a unique mechanism whereby IL-2 is exchanged from the Ab to IL-2Rα. However, clinical adoption of a mixed Ab/cytokine complex regimen is limited by stoichiometry and stability concerns. In this study, through structure-guided design, we engineered a single agent fusion of the IL-2 cytokine and JES6-1 Ab that, despite being covalently linked, preserves IL-2 exchange, selectively stimulating TReg expansion and exhibiting superior disease control to the mixed IL-2/JES6-1 complex in a mouse colitis model. These studies provide an engineering blueprint for resolving a major barrier to the implementation of functionally similar IL-2/Ab complexes for treatment of human disease.