bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic Nanoparticles: Current Trends and Future Aspects in Diagnostics and Nanomedicine
Authors: Vallabani Naga Veera Srikanth , Singh Sanjay , Karakoti Ajay Singh 
Published: November 2018

Background:
Biomedical applications of Magnetic Nanoparticles (MNPs) are creating a major impact on
disease diagnosis and nanomedicine or a combined platform called theranostics. A significant progress has been
made to engineer novel and hybrid MNPs for their multifunctional modalities such as imaging, biosensors, chemotherapeutic
or photothermal and antimicrobial agents. MNPs are successfully applied in biomedical applications
due to their unique and tunable properties such as superparamagnetism, stability, and biocompatibility. Approval of
ferumoxytol (feraheme) for MRI and the fact that several Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are
currently undergoing clinical trials have paved a path for future MNPs formulations. Intensive research is being
carried out in designing and developing novel nanohybrids for multiple applications in nanomedicine.

Objective:
The objective of the present review is to summarize recent developments of MNPs in imaging modalities
like MRI, CT, PET and PA, biosensors and nanomedicine including their role in targeting and drug delivery. Relevant
theory and examples of the use of MNPs in these applications have been cited and discussed to create a thorough
understanding of the developments in this field.

Conclusion:
MNPs have found widespread use as contrast agents in imaging modalities, as tools for bio-sensing, and
as therapeutic and theranostics agents. Multiple formulations of MNPs are in clinical testing and may be accepted in
clinical settings in near future.
Identification of the Altered Proteins Related to Colon Carcinogenesis by iTRAQ-based Quantitative Proteomic Analysis
Authors: Luo Chunhua , Yao Defu , Lim Teck Kwang , Lin Qingsong , Liu Yingfu 
Published: November 2018

Background:The molecular mechanisms or valuable biomarkers for early diagnosis of colorectal cancer (CRC) are not fully elucidated yet.Objective:To understand the proteomic changes at the global level in the carcinogenesis of CRC, differentially expressed proteins between normal intestinal epithelial cells CCD841 and colorectal cancer cells HCT116 were identified.Method:The isobaric tags for relative and absolute quantitation (iTRAQ) coupled with 2D LC-MS/MS proteomic approach were performed for screening the altered proteins between cells CCD841 and HCT116.Results:A total of 1947 proteins were identified after filtering and using a 1% false discovery rate. Based on a final cutoff (> 3.16 and < 0.32), 229 proteins were found to be significantly altered, among which 95 (41%) were up-regulated while 134 (59%) were down-regulated. Gene Ontology analysis revealed that the differentially expressed proteins were mainly cell part proteins involved in cellular process and binding in terms of subcellular distribution, biological process, and molecular function. KEGG analysis indicated that the differentially expressed proteins were significantly involved in the process of focal adhesion, pathogenic Escherichia coli infection, leukocyte transendothelial migration, bacterial invasion of epithelial cells, regulation of actin cytoskeleton, DNA replication and so on.Conclusion:Collectively, our data identified differentially expressed proteins in colon cancer carcinogenesis, which could provide the clues on unraveling the molecular mechanism of CRC.
Systemic Lupus Erythematosus: Symptoms and Signs at Initial Presentations
Authors: Metry Abdel Masieh , Al Salmi Issa , Al Balushi Farida , Yousef Mohammed Abdalla , Al Ismaili Faisal , Hola Alan , Hannawi Suad 
Published: November 2018

Background:
Systemic Lupus Erythematosus (SLE) is an autoimmune multisystem
inflammatory condition that causes microvascular inflammation with the production of
various auto-antibodies that play a major role in its pathogenesis. SLE can affect both sexes,
all ages, and all ethnic groups with widespread geographical and socioeconomic backgrounds.
Asia encompasses people of many sociocultural backgrounds with diverse ethnic.

Objective:
Due to a lack of national epidemiological research, the incidence and prevalence
of SLE in Middle Eastern and Arab countries, have only recently been studied. This article
aims to explore the status of SLE in Oman and to record symptoms and signs of SLE at first
presentation.

Methodology:
Medical records of all patients diagnosed with SLE at the Royal Hospital from
2006 to 2014 were reviewed for information recorded at first visit. SLE diagnosis was based
on the American College of Rheumatology classification criteria; ACR97 (which includes the
clinical manifestation and laboratory evidence). Patients with SLE disease manifestations extrapolated
and analyzed.

:
There were 966 patients diagnosed with SLE during the period from 2006 to 2014. Mean
(SD) age at presentations was 35.5 (11.5) years. Majority of patients were female which constitutes
88.7% of the total SLE patients with mean age 27.6 (1.4) years.

Results:
Constitutional symptoms were found in 48.68 of SLE population including fatigue in
35.22%, and weight changes in 13.43%.

:
The cutaneous manifestations that were present included malar rash 37.69%, photosensitivity
35.10%, discoid lupus 17.63%, and hair loss 39.29%.

:
Musculoskeletal manifestations were commonly seen among the studied population including
arthralgia in 68.75%, myalgia in 55.65%, arthritis in 48.31%, whilst myositis, tendon abnormalities
and avascular necrosis were found in only 2.47%, 0.31% and 1.98%. respectively.

Conclusion:
This is the first study of the symptoms and signs at initial clinical presentation of
SLE patients compared to other studies done regionally where most have focused on clinical
manifestations during the progression course of SLE. SLE manifestations may be related to
the differences in the genetic make-up of the patients who come from various ethnic groups
despite similar geography or sociocultural background, or to referral bias, as some studies
were performed in the nephrology units and others in the rheumatology units. There is a
pressing need to establish a nationwide and regional collaboration to establish LUPUS and to
put forward a strategic planning with each MOH to provide an easy and efficient report of
SLE cases and provide various effective management for such a debilitating syndrome.
Development and Performance Research of New Small Displacement Pump with Solid Plunger and Non-coaxial Delivery Valve
Authors: Zi-ming Feng , Weibo Duan , Wei Cui 
Published: November 2018

Background:
After the oilfield development coming into the middle and later periods,
many oil wells only had liquid production less than 5m3 per day, therefore the present sucker-rod
pumps didn’t satisfy the need for oilfield production. We revised all patents relating to small displacement
pump and didn’t found any suitable pump for low production well. A new type of pump
with small diameter was needed to design for solving the unbalance between the production and feed
in lower production wells.

Objective:
o resolve the problems of supply and production imbalance of the low producing well,
low pump efficiency and low system efficiency, a low displacement pump with non-coaxial delivery
valve had been designed.

Methods:
This type pump adopted a solid plunger, and its delivery valve was not coaxial with the
pump axial that would enhance its structural strength and been useful to reduce the partial flow loss
of oil flowing through the static pump valve. At the down dead point of pump plunger, the delivery
valve was located at the top of the pump chamber that was to the benefit of discharge of the gas and
the oil from the pump chamber. The uneven distribution of the delivery hole was suitable for the
wellhead diameter of the traditional oil wells.

Results:
The delivery valve was non-coaxial with the plunger that would decrease the flow loss
through the passage and increase the pump efficiency. At the down-dead point, the plunger entered
the extension nipple, and the delivery valve was located up the end of the solid plunger that promoted
the remnant gas flowing out of the pump cylinder and decreased the effect of gas on the pump efficiency.

Conclusion:
As to this low displacement pump, we suggested: The suitable stroke was 2-3m; the
stroke frequency was less than 3min-1. A reasonable range of submersible depth for low production
well was 200-300m. It was used in the gas content well lower than 20%, else used the gas anchor
firstly. The low displacement pump with non-coaxial delivery valve and solid plunger (NLDP) can
improve the pump efficiency and reduce the polish rod load. At the same time, this NLDP provides
new equipment for the production of the low oil well and improves the artificial lift design theory.
Utility of Molecular Imaging with 2-Deoxy-2-[Fluorine-18] Fluoro-D-Glucose Positron Emission Tomography (18F-FDG PET) for Small Cell Lung Cancer (SCLC): A Radiation Oncology Perspective
Authors: Sager Omer , Dincoglan Ferrat , Demiral Selcuk , Uysal Bora , Gamsiz Hakan , Elcim Yelda , Gundem Esin , Dirican Bahar , Beyzadeoglu Murat 
Published: November 2018

Background and Objective:
Although accounting for a relatively small proportion of all lung
cancers, small cell lung cancer (SCLC) remains to be a global health concern with grim prognosis. Radiotherapy
(RT) plays a central role in SCLC management either as a curative or palliative therapeutic strategy.
There has been considerable progress in RT of SCLC, thanks to improved imaging techniques leading
to accurate target localization for precise delivery of RT. Positron emission tomography (PET) is increasingly
used in oncology practice as a non-invasive molecular imaging modality.

Methods:
Herein, we review the utility of molecular imaging with 2-deoxy-2-[fluorine-18] fluoro-Dglucose
PET (18F-FDG PET) for SCLC from a radiation oncology perspective.

Results:
There has been extensive research on the utility of PET for SCLC in terms of improved staging,
restaging, treatment designation, patient selection for curative/palliative intent, target localization,
response assessment, detection of residual/recurrent disease, and prediction of treatment outcomes.

Conclusion:
PET provides useful functional information as a non-invasive molecular imaging modality
and may be exploited to improve the management of patients with SCLC. Incorporation of PET/CT in
staging of patients with SCLC may aid in optimal treatment allocation for an improved therapeutic ratio.
From a radiation oncology perspective, combination of functional and anatomical data provided by
integrated PET/CT improves discrimination between atelectasis and tumor, and assists in the
designation of RT portals with its high accuracy to detect intrathoracic tumor and nodal disease. Utility
of molecular imaging for SCLC should be further investigated in prospective randomized trials to acquire
a higher level of evidence for future potential applications of PET.
Dendrocalamus strictus Charcoal: An Efficient Adsorbent for Removal of Cu (II) Ions from Aqueous Solution and its Applicability in the Reduction of Genotoxic Potential of Cu (II) Ions
Authors: Saini Saraswati , Katnoria Jatinder Kaur , Kaur Inderpreet 
Published: November 2018

ABSTRACT: The present study pertains to evaluate the efficiency of Dendrocalamus strictus charcoal powder as an adsorbent to adsorb copper ions from aqueous solution under different conditions of pH, initial metal ion concentration, adsorbent dose, contact time, and temperature. Physical characterization of Dendrocalamus strictus charcoal powder was performed using different techniques such as scanning electron microscopy, scanning electron microscopy‐energy dispersive X‐ray spectroscopy, Brunauer Emmett and Teller surface analysis and X‐ray diffraction. Langmuir, Freundlich, and Temkin isotherm models were employed to describe the adsorption behavior of adsorbent in the removal of copper ions from aqueous solution. Thermodynamic parameters indicated that the adsorption of copper ions onto the surface of the adsorbent was feasible, spontaneous, and endothermic in nature. Data analysis using kinetic models revealed the pseudo‐second‐order as the suitable model to describe the process of adsorption. Studies were further carried out to analyze the genotoxic effects of copper ions in aqueous solution before and after adsorption, using Allium cepa assay. This study revealed that Dendrocalamus strictus charcoal powder could be applied as an alternative for more costly adsorbents in the detoxification of copper ions from aqueous solution.
MENJADI IBU HEBAT UNTUK MENURUNKAN PENOLAKAN IBU TERHADAP ANAK DENGAN GANGGUAN SPEKTRUM AUTIS (GSA)
Authors: Purwaningrum Devia , Wahyuningsih Hepi , Nugraha Sumedi P 
Published: November 2018

Abstrak. Sikap penerimaan ibu merupakan faktor penting dalam pengasuhan terhadap anak dengan gangguan spektrum autis (GSA). Ibu yang memiliki penerimaan yang tinggi mampu mengembangkan pengasuhan yang positif dan anak mampu berkembang secara optimal. Tujuan dari penelitian ini untuk mengetahui psikoedukasi Menjadi Ibu Hebat untuk menurunkan penolakan terhadap anak dengan GSA. Partisipan adalah tiga ibu yang memiliki anak dengan GSA. Pengumpulan data menggunakan parental acceptance-rejection scale (PARQ). Desain penelitian menggunakan quasi eksperimen one-group pretest-posttest. Analisis data dilakukan uji Friedman Test. Hasil uji statistik dengan uji Friedman Test menunjukkan bahwa tidak ada perbedaan yang signifikan antara sebelum dan sesudah diberikan penanganan, q =1,000, nilai signifikansi 0,607 (p>0,05). Kata kunci: Psikoedukasi, Penolakan Orangtua, Gangguan Spektrum Autis (GSA) Abstract. Mother acceptance is an important factor in caring for children with autism. A mother that has a high acceptance is capable of developing a positive parenting skill and as a result the children are able to grow optimally. This research aimed to examine the psychoeducation to be a great mother to reduce the rejection towards children with autism. The participants were three mothers who have children with autism. Data collection used the parental acceptance-rejection scale (PARQ). The study design using the experimental quasi of one-group pretest-posttest. Data analysis was conducted through the Friedman Test. The result of statistical test with Friedman Test showed no significant difference between before and after the treatment, q = 1,000, and significance value 0,607 (p> 0.05). Key words: Psychoeducation, rejection, parents, autism spectrum disorder (ASD).
BIOACTIVE COMPOUNDS OF SPONGE FOR AQUACULTURE AND POTENTIAL METHODS FOR SPONGE CULTIVATION
Authors: Asaf Ruzkiah , Samsi Andi Nur , Athirah Admi , Paena Mudian 
Published: November 2018

Aquaculture is an important sector for Indonesian economic, however, the spreads of diseases during farming remains a problem in developing Indonesian aquaculture. The sponge is known as the source of potential bioactive to combat pathogenic diseases in aquaculture. However, the intensifying exploitation of wild sponge tends to the depreses population of sponges in nature. This article reviews bioactive originating from sponges and potential methods in developing sponges cultivations under in-situ and ex-situ methodologies.
Analisis Faktor Eksploratori Layanan @syariahmandiri
Authors: Nugroho Arissetyanto 
Published: November 2018

The bank competition in Indonesia is high, conventional banks and sharia banks strive to improve competitiveness and gain positioning in the minds of the consumers. Previous research conducted by @bankmandiri compared to @syariahmandiri in 2015 gives the managerial implication that Syariah bank twitter is not as active as a conventional bank. @bankmandiri frequency compared to @syariahmandiri is different. Variety of the service proposition @syariahmandiri is fewer than the variety of service proposition @bankmandiri. The follow-up research is conducted by using the @syariahmandiri tweets data from January to Jul 2016. The data processed with the Provalis Research software, to obtain descriptive frequencies, hashtags, mentions and extracted name entities, cluster analysis, and to obtain the service proposition of @syariahmandiri. The results show a robust development @syariahmandiri twitter activities, an increasing number of tweet frequencies and varieties of service proposition compare with Jan Des 2015 dataset.
SYNTHESIS, SPECTRAL AND MOLECULAR CHARACTERIZATION OF SOME NOVEL 2, 5-DISUBSTITUTED-1, 3, 4–OXADIAZOLE DERIVATIVES AND EVALUATION OF IN VIVO ANTITUMOUR ACTIVITY AGAINST HT 29 CELL LINE
Authors: Bhaumik Asish , Eswaraiah M. Chinna , Chakraborty Raja 
Published: November 2018

Neoplasia is a type of abnormal and excessive growth of tissue. The growth of a neoplasia is uncoordinated with that of the normal surrounding tissue, and it persists growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass. The main objective of the present research work was the synthesis, characterization and evaluation of in vivo antitumour activity of some novel 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives. The in vivo antitumour activity of synthesized compounds was evaluated by HT 29 cell line induced malignant ascites on mouse model. The apoptosis of HT 29 cells was evaluated by using Gimsa and H33342 stain and the apoptosis ratios were analysed by FCM using AnnexinV-FITC/PI staining. The present experimental data displayed that the mortality was less in all groups except in tumour control group and all the synthesized compounds AB1-AB8 (100 mg/kg) significantly increased the PILS. While 5-FU increased the life span of 97.72%, and the PILS of synthesized compounds were found to be 45.45%, 59.09%, 68.18%, 56.81%, 38.63%, 84.09%, 77.27% and 90.90%. So the Synthesized compounds AB1-AB8 at the dose of 100 mg/kg significantly improved the overall survival of all treated animals and 5-FU was not significantly differed from each other in improving the overall survival of HT-29 cells. The apoptosis ratios of synthesized compounds were found as followed: AB1=26%; AB2=37.6%; AB3=43%; AB4=29%; AB5=24.1%; AB6=59.2%; AB7=48.2%; and AB8=63% respectively, while that of the Group-II (T. control) was 6.1%. When compared with standard drug 5-FU: 66.2%, it was indicated that compound AB8>AB6>AB7>AB3 were able to significantly induce HT-29 cells apoptosis.
FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF ELETRIPTAN FAST DISSOLVING ORAL FILMS
Authors: Somwanshi Shrushti V. , Thonte Sanjay S. 
Published: November 2018

The present study aimed at preparing fast dissolving oral films of Eletriptan as a model drug which is used for the migraine treatment. Fast dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties. In the present research work various trials were carried out using different grades of HPMC E3, E6, and E15, maltodextrin DE6 and other polymers by solvent casting method. The prepared films were evaluated for film thickness, folding endurance, surface pH, morphological properties, % drug content and content uniformity, tensile strength, percent elongation, in vitro disintegration time and in vitro dissolution studies. The optimized formulation F24 prepared using HPMC E15 showed minimum disintegration time (10 sec), highest dissolution rate i.e. 99% of drug within 8 min and satisfactory physicochemical properties. The optimized film was evaluated for its bioavailability compared with pure drug as reference standard. Statistical analysis revealed that no significant difference between the bioavailability parameters of the film and the reference standard indicated that they exhibited comparable plasma level-time profiles. These findings suggest that the fast dissolving film containing Eletriptan is considered to be potentially useful for the treatment of migraine where quick onset of action is desirable.
ANTIULCER ACTIVITY OF METHANOLIC EXTRACT OF ROOTS OF BETA VULGARIS, CHENOPODIACEAE
Authors: Jagtap Manoj Jagannath , Deore Amol Bhalchandra 
Published: November 2018

Beta vulgaris (chenopodiacea) is a medicinal plant reported for its variety of ethnic medicinal uses. Beta vulgaris showed antioxidant, anticancer, hepatoprotective, nephroprotective, wound healing, and anti-inflammatory activities. Hence we have planned to screen antiulcer activity of root of the plant with the methanolic extract. Root powders successively extracted with methyl alcohol and were subjected for phytochemical screening to identify different phytoconstituents. The methanolic extracts of roots of Beta vulgaris were investigated for ulcer protective activity against pyloric-ligation, ethanol induced gastric lesion and cold restraint stress induced ulcers. Preliminary phytochemical screening revealed the presence of flavonoids, saponins, sterols, and alkaloids. The extract was tested for their lethal effect up to the dose level of 2000 mg/kg. None of them have produced abnormal behavior or mortality in rats. Further methanolic extract of 200 and 400 mg/kg/p.o significantly (p˂0.01) reduced the ulcer score, ulcer number, ulcer index, free acidity and total acidity in pyloric-ligation, ethanol induced gastric lesion and cold restraint stress induced ulcer models in rats. The present study revealed that the root extract of Beta vulgaris has antiulcer activity.
Ciudad
Authors: Velasco Paola 
Published: November 2018

Paola Velasco (Xalpa, 10977) es autora de Las huellas del gato, Veredas para un centauro, Rotación del tiempo. Preparó la antología de Alfonso Reyes Romances del Río de Enero y otros poemas para la Universidad Externado de Colombia. Dirige el Programa Cultural Tierra Adentro.
MANEJO DE LA VÍA AÉREA PEDIÁTRICA
Authors: JIMÉNEZ HERNÁNDEZ ALEJANDRA , PARDO DÍAZ EDWIN 
Published: November 2018

Para entender, diagnosticar y tratar las condiciones patológicas propias de la vía aérea del niño, es necesario un adecuado conocimiento de su anatomía y fisiología. La vía aérea del adulto es completamente diferente a la del niño, haciendo a los pacientes pediátricos no solo más susceptibles a desórdenes originados en la vía aérea sino de mayor severidad, aunado a la baja exposición que los proveedores de salud en ambientes pre e intrahospitalarios pueden llegar a tener. En esta revision se incluye la descripción anatómica de la vía aérea pediátrica, el proceso fisiológico de la respiración, el comportamiento del sistema respiratorio frente a procesos patológicos y el abordaje de la vía aérea en el paciente pediátrico.