bluuebunny/crossref_metadata_2025_split huggingface dataset:
Side-to-Side Differences in Varus Thrust and Knee Abduction Moment in High-Functioning Individuals With Chronic Anterior Cruciate Ligament Deficiency
Authors: Ismail Shiek Abdullah , Simic Milena , Salmon Lucy J. , Roe Justin P. , Pinczewski Leo A. , Smith Richard , Pappas Evangelos 
Published: December 2018

Background: There is evidence that frontal plane knee joint motion plays a crucial role in the pathogenesis of knee osteoarthritis, yet investigation of individuals with chronic anterior cruciate ligament–deficient (ACLD) knees remains sparse. Purpose: To investigate (1) if individuals with chronic ACLD knees demonstrate higher biomechanical measures of medial knee load as compared with their anterior cruciate ligament–intact (ACLI) knees, (2) if differences in static knee alignment of the ACLD knee will demonstrate a difference in the magnitude of biomechanical measures of medial knee load when compared with the ACLI knee, and (3) the side-to-side concordance of varus thrust among individuals with chronic ACLD knees. Study Design: Descriptive laboratory study. Methods: Participants were sourced from a metropolitan orthopaedic surgeon group. Those who met the inclusion criteria and agreed to participate underwent a 3-dimensional gait analysis assessment to measure knee adduction moment (KAM), knee flexion moment (KFM), KAM peaks, KAM impulse, and varus thrust. Frontal plane knee static alignment was measured with a digital inclinometer fixed to medical calipers. The participants were divided according to their static knee alignment (neutral, varus, and valgus) for subgroup analysis. Peak knee angular velocity and frontal plane knee angle were used to establish if a participant was walking with a knee thrust. An individual was deemed to have knee thrust during gait if the largest frontal plane knee movement coincided with the peak knee angular velocity that occurred within the first 30% of stance phase. Results: Forty-five participants were recruited. The mean (SD) time from injury was 34.5 (55.6) months. ACLD knees did not demonstrate higher mean KAM and KFM ( P > .5) or early-stance peak KAM ( P = .3-.8) and KAM impulse ( P = .3-.9) as compared with ACLI knees as a whole group or when the varus, neutral, and valgus alignment subgroups were investigated separately. Twenty-three percent (n = 9) of the participants had a varus thrust at the ACLD or ACLI knee, 44% (n = 4) had a varus thrust at the ACLD knee, and 22% (n = 2) had varus thrust at both knees. Conclusion: There were no side-to-side differences in mean KAM and KFM and early-stance peak KAM and KAM impulse among high-functioning individuals with chronic unilateral ACLD knees. There was a low prevalence of varus thrust among high-functioning individuals with chronic unilateral ACLD knees.
Improving health literacy and medication compliance through comic books: a quasi-experimental study of Chinese community-dwelling older adults
Authors: Leung Angela Y. M. , Leung Isaac S. H. , Liu Justina Y. W. , Ting Sylvia , Lo Selina 
Published: December 2018

Background: This study aims to investigate the effect of two interventions (verbal advice and comic books) on health literacy and medication compliance among older adults living in 15 public estates in Hong Kong. Methods: This is a two-phase multi-site quasi-experimental study with a pre-and-post design with four measurement points (T1–T4). In both phases, the two interventions were conducted by trained medical/nursing/pharmacy students. Two home visits were carried out in each phase. After the baseline measurement at Time 1 (T1), students verbally advised the older adult participants on how to read, understand, and interpret information on drug labels and how to store drugs properly. A post-assessment was conducted at T2. One year later, another pre-assessment was conducted at T3, and then students used a comic book to educate the older adults. A post-assessment was carried out at T4 after the use of the comic book. Health literacy was measured using the 24-item Chinese Health Literacy Scale for Chronic Care and medication compliance was measured using the Medication Compliance, Knowledge and Storage scale. Generalised Linear Mixed Models were used. Results: A total of 165 subjects were included. The majority (60.6%) were female, aged from 67 to 96. About half (47.3%) had received no formal education. Controlling for age and cognition, there was a significant increase in health literacy after the use of the comic book (coefficient = 2.742, p = 0.001). There was also a significant improvement in medication compliance (total score) (coefficient = −1.018, p < 0.001), reduced knowledge deficiency (coefficient = −0.236, p < 0.05), and reduced storage problems (coefficient = −0.293, p = 0.001) after using comic books. Conclusion: Comic books are a good strategy to improve the health literacy level and medication compliance of community-dwelling older adults.
Monitoring cognitive change in multiple sclerosis using a computerized cognitive battery
Authors: De Meijer L , Merlo D , Skibina O , Grobbee EJ , Gale J , Haartsen J , Maruff P , Darby D , Butzkueven* H , Van der Walt A 
Published: December 2018

Background Cognitive monitoring that can detect short-term change in multiple sclerosis is challenging. Computerized cognitive batteries such as the CogState Brief Battery can rapidly assess commonly affected cognitive domains. Objectives The purpose of this study was to establish the acceptability and sensitivity of the CogState Brief Battery in multiple sclerosis patients compared to controls. We compared the sensitivity of the CogState Brief Battery to that of the Paced Auditory Serial Addition Test over 12 months. Methods Demographics, Expanded Disability Status Scale scores, depression and anxiety scores were compared with CogState Brief Battery and Paced Auditory Serial Addition Test performances of 51 patients with relapsing–remitting multiple sclerosis, 19 with secondary progressive multiple sclerosis and 40 healthy controls. Longitudinal data in 37 relapsing–remitting multiple sclerosis patients were evaluated using linear mixed models. Results Both the CogState Brief Battery and the Paced Auditory Serial Addition Test discriminated between multiple sclerosis and healthy controls at baseline ( p<0.001). CogState Brief Battery tasks were more acceptable and caused less anxiety than the Paced Auditory Serial Addition Test ( p<0.001). In relapsing–remitting multiple sclerosis patients, reaction time slowed over 12 months ( p<0.001) for the CogState Brief Battery Detection (mean change –34.23 ms) and Identification (–25.31 ms) tasks. Paced Auditory Serial Addition Test scores did not change over this time. Conclusions The CogState Brief Battery is highly acceptable and better able to detect cognitive change than the Paced Auditory Serial Addition Test. The CogState Brief Battery could potentially be used as a practical cognitive monitoring tool in the multiple sclerosis clinic setting.
Reverse digital artery cross-finger flap for reconstruction of failed finger replantation
Authors: Kim Dong Hee , Seo Kyu Bum , Lee Sang Hyun , Lee Hee-Jin , Kang Hong Je 
Published: December 2018

Purpose: This study aimed to describe the reverse digital artery cross-finger flap (RDAC flap) in the treatment of failed finger replantation. Methods: This study retrospectively reviewed the records of patients who underwent modified RDAC flap reconstructions for failed finger replantation and assessed their outcomes. Of the patients who underwent soft tissue reconstructions for finger injuries between March 2011 and February 2015, we enrolled 11 patients in whom RDAC flap reconstruction procedures were performed to treat the failed replantations. Results: The flaps survived in all cases, with a mean static, two-point discrimination value of 5.3 mm (range, 4–7 mm) in the healed flaps. The sizes of the flaps ranged from 2 × 1 cm2 to 2.3 × 1.5 cm2. Conclusion: The RDAC flap was introduced by Lai et al., and it is a mixed form with the advantages of both cross-finger flap and heterodigital island flap. Our results suggest that it could provide reliable coverage of the sensate soft tissue of fingers with failed replantation.
Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity
Authors: Suraneni Praveen K. , Corey Seth J. , Hession Michael J. , Ishaq Rameez , Awomolo Arinola , Hasan Shirin , Shah Chirag , Liu Hui , Wickrema Amittha , Debili Najet , Crispino John D. , Eklund Elizabeth A. , Chen Yolande 
Published: December 2018

Abstract
Megakaryocyte (MK) migration from the bone marrow periosteal niche toward the vascular niche is a prerequisite for proplatelet extension and release into the circulation. The mechanism for this highly coordinated process is poorly understood. Here we show that dynasore (DNSR), a small-molecule inhibitor of dynamins (DNMs), or short hairpin RNA knockdown of DNM2 and DNM3 impairs directional migration in a human MK cell line or MKs derived from cultured CD34+ cells. Because cell migration requires actin cytoskeletal rearrangements, we measured actin polymerization and the activity of cytoskeleton regulator RhoA and found them to be decreased after inhibition of DNM2 and DNM3. Because SDF-1α is important for hematopoiesis, we studied the expression of its receptor CXCR4 in DNSR-treated cells. CXCR4 expression on the cell surface was increased, at least partially because of slower endocytosis and internalization after SDF-1α treatment. Combined inhibition of DNM2 and DNM3 or forced expression of dominant-negative Dnm2-K44A or GTPase-defective DNM3 diminished β1 integrin (ITGB1) activity. DNSR-treated MKs showed an abnormally clustered staining pattern of Rab11, a marker of recycling endosomes. This suggests decreased recruitment of the recycling pathway in DNSR-treated cells. Altogether, we show that the GTPase activity of DNMs, which governs endocytosis and regulates cell receptor trafficking, exerts control on MK migration toward SDF-1α gradients, such as those originating from the vascular niche. DNMs play a critical role in MKs by triggering membrane-cytoskeleton rearrangements downstream of CXCR4 and integrins.
Foot and ankle characteristics and dynamic knee valgus in individuals with patellofemoral osteoarthritis
Authors: Wyndow Narelle , Collins Natalie J. , Vicenzino Bill , Tucker Kylie , Crossley Kay M. 
Published: December 2018

AbstractStudy designControlled laboratory study; cross‐sectional design.BackgroundFoot and ankle characteristics and dynamic knee valgus differ in people with and without patellofemoral (PF) pain. However, it is unknown if these characteristics are evident in people with PF osteoarthritis (OA), compared to pain‐free older adults.ObjectivesTo compare foot and ankle mobility, foot posture and dynamic knee valgus, measured as the frontal plane projection angle (FPPA) during single‐leg squatting, between individuals with and without PFOA.MethodsFifty‐one participants with PFOA (66% women, mean ± SD age 57 ± 10 years, body mass index (BMI) 27 ± 6 kg/m2), and 23 controls (56% women, age 56 ± 9 years, BMI 24 ± 4 kg/m2) had ankle dorsiflexion measured using the knee‐to‐wall test, foot mobility calculated as the difference in midfoot height or width between non‐weightbearing and weightbearing, and static foot posture characterized utilizing the Foot Posture Index. Peak FPPA was determined from video recordings while participants performed 5 single‐leg squats. Linear regressions examined between‐groups relationships for foot and ankle characteristics and the FPPA.ResultsThe PFOA group had less ankle dorsiflexion (odds ratio 6.7, 95% confidence interval 2.46–18.2), greater midfoot height mobility (5.2, 1.78–15.14) and width mobility (4.3, 1.33–14.39), and greater foot mobility magnitude (8.4, 2.32–30.69) than controls. There was no difference in FPPA (knee valgus angle) between groups (15, 0.63–377.99).ConclusionFoot and ankle characteristics were different in individuals with PFOA compared to control participants, however there was no difference in dynamic knee valgus during single leg squat. Clinical interventions to address greater foot mobility may be relevant for PFOA.
The challenge of differentiating vaso-occlusive crises from osteomyelitis in children with sickle cell disease and bone pain: A 15-year retrospective review
Authors: Fontalis A. , Hughes K. , Nguyen M. P. , Williamson M. , Yeo A. , Lui D. , Gelfer Y. 
Published: December 2018

Purpose The paediatric sickle cell disease (SCD) osteomyelitis (OM) incidence is 0.3% to 12%. Differentiating vaso-occlusive crises (VOC) from OM is a diagnostic challenge, with limited evidence guiding management. We present a 15-year review of a paediatric sickle cell cohort. We aim to identify OM incidence and provide a management protocol for these children presenting with bone pain. Methods A prospective database of children with haemoglobinopathies (2002 to 2017) was analyzed for temperature, C-reactive protein (CRP) and white cell count (WCC) on admission as well as imaging, treatment and cultures. OM diagnosis was supported by imaging and blood cultures. VOC was defined as bone pain that improved without antibiotics. Results Over 15 years, 96 children with SCD presented 358 times to hospital. Empirical antibiotics were given in 308 presentations. There were five cases of OM (1.4%); two acute and three chronic. In all, 50 presentations of VOC were identified. No significant differences in age were noted between the OM and VOC group. Temperature and CRP were significantly elevated in the OM group with no significant difference in WCC. Cultures were only positive in the chronic OM admissions. There were no cases of septic arthritis. No surgical intervention was required. Conclusion In children with SCD presenting with persistent bone pain, fever, elevated CRP and WCC, OM should be suspected and prompt antibiotic treatment started. Our treatment pathway was successful avoiding OM in 98.6% and septic arthritis in 100%. Further research on novel biological markers distinguishing OM from VOC should be investigated. Level of Evidence III
Shift working reduces operative experience for trauma and orthopaedic higher surgical trainees: a UK multicentre study
Authors: Sevenoaks H , Ajwani S , Hujazi I , Sergeant J , Woodruff M , Barrie J , Mehta J 
Published: December 2018

Introduction In recent years there has been a rise in the number of trauma and orthopaedics trainees working on full shift patterns. Historically, most trauma and orthopaedics trainees worked 24 hours non-resident on-call shifts. The effect of this change in shift patterns has not previously been measured. As two trusts (one trauma unit, one major trauma centre) in our region underwent a change to full shift working, we assessed the impact on the trainees’ operating experience. Methods Fifty-five logbooks were analysed across the two trusts over a two-year period, with comparisons made between pre- and post-shift working. Results Overall operating fell by 13% for trainees working full shift patterns, which was statistically significant. There was a loss of elective operating of 15% at the trauma unit and 32% at the major trauma centre for trainees doing shift work. The effect on trauma operating opportunities was mixed. Index operating was largely preserved. Conclusions Shift working significantly impacts on surgical training opportunities. We explore approaches to minimising this effect.
A Tool for Assisted Correction of Programming Exercises in Java Based in Computational Reflection
Authors: Santos Francisco Alan De Oliveira 
Published: December 2018

INTRODUCTION: This work reports on the creation and use of a tool to verify compliance in java programming exercises. The solution is based on the hypothesis that computational reflection can provide a way to automatically assess the programing competences of students. The work reflects the concern to make students learning a programming language have practical activities in parallel to what they learn in theoretical classes. OBJECTIVE: Attesting the effectiveness of using computational reflection to automatically correct programming exercises. Provide the teacher with a tool to support the follow-up of practical activities. Provide students with immediate feedback on their learning, so as to encourage them to behave more autonomously. METHOD: A case study was carried out with two classes of a computer sciencecourse. They answered five practical programming exercices and their responses for each activity were collected in source code format, which were used as the basis of solutions, totaling 100 responses.A comparative analysis was made between the notes obtained through CodeTeacher and the notes assigned by a group of teachers. RESULTS: Comparing the expected notes and the actual notes, the automatic correction obtained an accuracy of 90.17%. CONCLUSION: The use of computational reflection techniques for assisted correction in programming classes can bring beneficial result. Teachers can optimize their work and have performance reports of their students. Students can also be benefited by having an immediate feedback, so they can perceive themselves capable of achieving the learning objectives defined by the teacher.
GAL4Drivers Specific for Type Ib and Type Is Motor Neurons inDrosophila
Authors: Pérez-Moreno Juan J , O’Kane Cahir J 
Published: December 2018

AbstractThe Drosophila melanogaster larval neuromuscular system is extensively used by researchers to study neuronal cell biology, and Drosophila glutamatergic motor neurons have become a major model system. There are two main Types of glutamatergic motor neurons, Ib and Is, with different structural and physiological properties at synaptic level at the neuromuscular junction. To generate genetic tools to identify and manipulate motor neurons of each Type, we screened for GAL4 driver lines for this purpose. Here we describe GAL4 drivers specific for examples of neurons within each Type, Ib or Is. These drivers showed high expression levels and were expressed in only few motor neurons, making them amenable tools for specific studies of both axonal and synapse biology in identified Type I motor neurons.
Clinical Applications of Raman Spectroscopy in Inflammatory Bowel Diseases. A Review
Authors: Tefas Cristian , Tanțău Marcel 
Published: December 2018

Background & Aims: Inflammatory bowel diseases are still difficult to diagnose and differentiate in some cases despite the serological, imaging, endoscopic and histopathological armamentarium. Raman spectroscopy is a technique that could help with these shortcomings. The aim of this paper is to present the accuracy of Raman spectroscopy in the diagnosis and monitoring of patients with inflammatory bowel diseases.Methods: We identified the published manuscripts and abstracts up to the 31st of December 2017 by a systematic search of Medline, Embase, Cochrane and other trial registries.Results: Eight publications were found, showing sensitivities and specificities of Raman spectroscopy in diagnosing and differentiating inflammatory bowel diseases ranging from 82 to 99% and 57 to 99%, respectively, and accuracies of up to 95%.Conclusion: The technique has so far proven its potential in the positive and differential diagnosis of Crohn’s disease or ulcerative colitis, allowing for very rapid results with high sensitivity and specificity.
Prognostic Factors after Percutaneous Radiofrequency Ablation in the Treatment of Hepatocellular Carcinoma. Impact of Incomplete Ablation on Recurrence and Overall Survival Rates
Authors: Sparchez Zeno , Mocan Tudor , Radu Pompilia , Mocan Lavinia Patricia , Sparchez Mihaela , Leucuta Daniel Corneliu , Al Hajjar Nadim 
Published: December 2018

Aims: To report on the long-term impact of tumor and non-tumor related parameters on local recurrence, distant recurrence and survival in patients with naïve or recurrent type hepatocellular carcinoma (HCC) treated by radiofrequency ablation (RFA).Methods: We performed 240 RFA sessions on 133 patients with 156 HCC nodules developed on a background of liver cirrhosis and analyzed the outcomes.Results: Contrast-enhanced ultrasound performed one month after RFA showed complete ablation in 119 out of 133 (89.65%) patients. With a median follow-up of 46 months, 3-, 5- and 7-year survival rates were 61.7%, 35.7%, and 22.6%, respectively. Previous ethanol injection and histological grade were significantly related to local tumor progression. Child-Pugh class, incomplete ablation, histological grade, previous ethanol injection, alpha-fetoprotein level before the treatment, and local recurrence were all significantly related to distant recurrence. Multivariate analysis demonstrated that age, Child-Pugh class, distant recurrence and multiple incomplete ablations were significantly related to survival.Conclusion: Radiofrequency ablation could be locally curative for HCC, resulting in a survival longer than 7 years. Previous ethanol injection and incomplete ablations were strongly associated with poor outcomes.
Years of Life Lost due to Diseases of the Digestive System in Poland in 2000-2014
Authors: Paciej-Gołębiowska Paulina , Pikala Małgorzata , Maniecka-Bryła Irena 
Published: December 2018

Background & Aims: Diseases of the digestive system substantially contribute to premature mortality of the Polish population. Years of Life Lost (YLLs) are more and more commonly used in order to evaluate social and economic aspects of these deaths. The aim of the study was to analyse YLLs due to diseases of the digestive system in Poland between 2000-2014.Methods: The study material included a database which contained information gathered from 5,601,568 death certificates of Poles who died between 2000-2014. Data on deaths due to diseases of the digestive system were used for the analysis (i.e. coded as K00-K93 according to International Statistical Classification of Diseases and Related Health Problems, 10th Revision). Standard Expected Years of Life Lost (SEYLL) wasused to calculate YLLs.Results: In 2000-2014 diseases of the digestive system contributed to 239,176 deaths of Poles (4.3% of all deaths), which corresponded to 5,470,096.8 YLLs (95.2 years per 10,000 population). Each death due to the above cause was responsible for the average loss of 22.9 years. Diseases of the liver, including alcoholic liver disease and fibrosis and cirrhosis of the liver, contributed to the highest number of YLLs (54.1%).Conclusions: Of all digestive diseases, the dominant causes of YLLs are alcohol-related liver diseases. In order to minimize this phenomenon, it is important to intensify public health activities, aimed at combating alcohol addiction in Poland.
ANATOMI KEABSAHAN BUNGA BANK DALAM PERSPEKTIF TEORI LIMIT MUHAMMAD SYAHRÛR
Authors: Qadir Dadang Abdul 
Published: December 2018

Riba is an excess of the capital, which is including all types of loans that used a lot or a little an extra. The majority of Muslim stated that interest and usury (riba) are the same, so that the interest became haram. Nevertheless, Muhammad Syahrûr said that the interest is not usury (riba), for not reaching 100% of the capital invested. He used a different methodology than the majority of Muslim scholars. He developed his own methodology in making a law. One of them is the theory of limits. The term limits (hudûd) is used referring to the sense of the limits of the provisions of God that should not be violated, but there is a region for ijtihâd which are dynamic, flexible, and elastic. The method used in this paper is descriptive, whereas technical for collecting data is literature study, especially the book written by Muhammd Syahrûr , namely al-Kitâb wa al-Qur’ân: Qirâ’ah Mu‘âshirah.