bluuebunny/crossref_metadata_2025_split huggingface dataset:
The moderation effect of mental health services use on the relationship between exposures to adverse childhood experiences and mental health outcomes among US adolescents
Authors: Kim Lyoung Hee , Lee Seung Joo , Ahn So Young 
Published: December 2024

BackgroundThe prevailing exposure to Adverse Childhood Experiences (ACEs) among youth is associated with adolescents' mental health. However, few studies have examined whether receiving help from mental health services affects mental health outcomes among adolescents with ACEs. Therefore, this study examines the moderated effects of mental health services use on the relationship between exposures to ACEs and mental health outcomes among US adolescents.MethodsThe sample was restricted to adolescents aged 11–17 using data from the National Health Interview Survey (NHIS) from 2019, 2021, and 2022. Multivariate logistic regressions and descriptive analyses were performed to estimate the moderation effect of mental health services use.ResultsUsing mental health services buffered the associations between ACEs and severe anxiety and depressive symptoms. Receiving counseling/therapy moderated the impact of ever living with an individual who had severe anxiety (Adjusted Odds Ratio, AOR: 0.58, p < .05) and depressive symptoms (AOR: 0.38, p < .01) among adolescents. Furthermore, counseling/therapy moderated the effect of ever living with an individual with a history of alcohol or drug abuse on severe depressive symptoms (AOR: 0.49, p < .05) and the effect of being a victim or witness of violence on severe anxiety symptoms (AOR: 0.45, p < .01). In addition, taking prescription medication moderated the effect of the experience of incarcerated family members on severe anxiety symptoms (AOR: 0.41, p < .05).ConclusionOur findings suggest that policy and practice need to encourage access to mental health care for vulnerable adolescents with ACEs to reduce the detrimental effect of their experiences on their mental health problems.
Food Allergy in Children in China
Authors: Leung Agnes Sze‐Yin , Jie Shao , Gu Yanjun , Wong Gary Wing‐Kin 
Published: December 2024

ABSTRACTThe prevalence of food allergies in China seems to be increasing, but there are limited studies describing the pattern of food allergies across the country. This review highlights regional variations observed across China, with data indicating a higher prevalence in the more economically developed eastern and southern coastal regions compared to inland areas. Egg and milk are the most common allergies among children under 3 years old; for children above 3 years old, specific food allergens also show regional differences, with shellfish allergies being more common in southern and eastern coastal areas, while wheat and fruit allergies are more prevalent in northern regions. Emerging peanut and tree nut allergies have also been observed in China's megacities, although the prevalence remains relatively low compared to Western countries. These geographic and environmental influences highlight the complexity of the food allergy landscape in China and the need for a more nuanced understanding of the underlying drivers. Despite the growing burden of food allergies, significant gaps exist in effectively managing these conditions in China. Lack of standardised diagnostic tools, limited access to oral food challenges and a shortage of trained allergists pose major challenges. Another critical gap is the limited availability and affordability of epinephrine autoinjectors, essential for managing life‐threatening anaphylactic reactions. Addressing these systemic deficiencies in China's food allergy management infrastructure will require concerted efforts from policymakers, healthcare systems and pharmaceutical companies. Investing in the development of standardised diagnostics, expanding the allergy speciality workforce and ensuring equitable access to emergency care and treatment options are crucial steps towards improving health outcomes for the millions of individuals affected by food allergies in China.
Pattern of Ophthalmic Injuries in Patients With Maxillofacial Fractures at a Tertiary Care Centre in Central India
Authors: Khan Tauseef Ahmed , Tripathi Geeta Mishra , Mishra Ambrish , Sharma Divashree , Dwivedi Anamika 
Published: December 2024

ABSTRACTIntroductionMaxillofacial injuries are usually associated with ophthalmic injuries that may be mild to severe, and may even result in loss of integrity of the orbital skeleton and impairment of the visual apparatus.AimTo evaluate the pattern of ophthalmic injuries associated with maxillofacial fractures in patients who reported to a tertiary care hospital, associated with a medical college in M.P, India.Material and MethodsThe records of patients who sustained ophthalmic injuries with maxillofacial trauma from 1st January 2012 to 31st January 2024 and reported to the Department of Dentistry of a tertiary care hospital were evaluated. The data related to demographic characteristics, aetiology of trauma, type of maxillofacial fractures and pattern of ophthalmic injuries were gathered and analysed.ResultsA total of 1575 patients with maxillofacial trauma reported to the institute during the study duration. The study sample comprised 1046 (66.41%) maxillofacial trauma patients who sustained ophthalmic injuries. Males were more commonly involved (85.85%) than females (14.15%). The commonly involved age group was 21–30 years with 34.32% of patients belonging to the age group. The most common aetiology was road traffic accidents, reported in 71.89% of patients. Zygomaticomaxillary complex (ZMC) fractures were evident in 73.52%, mandibular fractures in 50.19%, naso‐orbito‐ethmoidal (NOE) fractures in 19.41% and frontal bone fractures in 18.74% patients. Subconjunctival haemorrhage was seen in 79.83%, periorbital ecchymosis in 72.94% and periorbital oedema in 60.32% of cases. Retrobulbar haemorrhage was seen in 2.58%, traumatic optic neuropathy in 2.01% and retinal detachment in 0.86% of cases.ConclusionOphthalmic injuries were seen frequently in 66.41% of cases with maxillofacial trauma, particularly in zygomatic complex fractures (73.52%). The findings emphasise that the competency of maxillofacial surgeons plays a vital role in comprehending the severity and management of post‐traumatic ophthalmic consequences in maxillofacial injuries. Also, ophthalmological evaluation in maxillofacial trauma, particularly involving the midface should be considered mandatory.
Neuronal HIF‐1α expression in mediobasal hypothalamus affects glycolipid metabolism and body weight in mice fed with high‐fat diet
Authors: Ma Lijuan , Rozjan Azmat , Duolikun Dilihumaier , Guo Hai , Yao Qiaoling 
Published: December 2024

AbstractThis study aimed to explore the interaction between the expression of neuronal HIF‐1α in the mediobasal hypothalamus and food intake, glycolipid metabolism and body weight (BW) in mice consuming high‐fat diet (HFD). In HIF‐1αflox/flox mice, AAV‐hSyn‐GFP (NC group) or AAV‐hSyn‐cre‐GFP (KD group) virus was injected into medial base of the hypothalamus. Frozen brain tissue sections confirmed the presence of the virus within the hypothalamus of mice after 28 days of AAV injection, including reporter signals within the arcuate nucleus, dorsomedial hypothalamic nucleus (DMH) and ventromedial hypothalamus (VMH). Consistently, the levels of HIF‐1α mRNA in the ventral hypothalamus were significantly lower in the KD group compared to the NC group. These KD mice also demonstrated significantly increased food intake, body weight (BW), total cholesterol (TC), high‐density lipoprotein (HDL), low‐density lipoprotein (LDL) and serum insulin, combined with higher blood glucose, compared to NC animals. However, the levels of triglycerides and FFA were similar in both groups. Significant differences in p‐Akt levels were not observed in the skeletal muscle, liver or epididymal fat in KD mice after insulin injection. In conclusion, the knockdown of HIF‐1α within the neurons of mediobasal hypothalamus results in an increase in the appetite of mice fed with HFD, which in turn leads to a significant dysregulation of lipid and glucose metabolism and a corresponding increase in weight. Therefore, the neuronal HIF‐1α expression in the mediobasal hypothalamus may be a critical regulator of glycolipid metabolism and body weight control when a high‐fat diet is consumed.
Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia
Authors: Alharbi Homood , Ahmad Mohammad , Cui Zhong , Meng Dong , Xin Ying , Yan Xues 
Published: December 2024

ABSTRACTObjectiveIn this study, clinical bioinformatics analysis was used to identify potential biomarkers of acute myeloid leukemia (AML) occurrence and development, drug resistance, and poor prognosis to provide a theoretical basis for the treatment of AML.MethodsOn the basis of the TCGA, GEO, and GTEx databases, an AML secondary database was established, and differential expression analysis and WGCNA were carried out to identify genes related to the prognosis of AML patients. Survival analysis was carried out for internal verification of key genes, and GEO data were used for external verification to obtain core genes related to prognosis. For differentially expressed genes, the EpiMed platform independently developed by the team was used for drug prediction.ResultsA total of 36 overlapping genes were obtained via difference analysis and WGCNA. Enrichment analysis revealed that the overlapping genes were associated with neutrophil activation, transcription dysregulation, AML, apoptosis, and other biological indicators. A protein interaction network was constructed for NCOA4, ACSL4, DPP4, ATL1, MT1G, ALOX15, and SLC7A11, which are key genes. Survival analysis revealed that NCOA4, ACSL4, DPP4, and ATL1 significantly affected the survival of patients with AML. The GSE142698 dataset verified that MPO, BCL2A1, and STMN1 had a statistically significant impact on the survival of AML patients.ConclusionNCOA4, ACSL4, DPP4, and ATL1 may be potential biomarkers related to the survival and prognosis of patients with AML, and the calcineurin signaling pathway is associated with the risk of vascular fragility in AML patients, which can provide a reference for further research and optimization of treatment regimens.
Paternal Physical Punishment and Neglect: Does It Increase the Odds of Toothache in Children and Adolescents?
Authors: de Aquino Goulart Mariél , Possebon Müller Letícia , Oliva Vinholes Anelisa , Mello dos Santos Camila , Celeste Roger Keller 
Published: December 2024

ABSTRACTBackgroundPhysical punishment by caregivers affects approximately 60% of children between the ages of 2 and 14 worldwide.AimTo evaluate the association between physical punishment and paternal neglect of children and adolescents and toothache.DesignThis cross‐sectional study included all schoolchildren between the ages of 9 and 19 from a small Brazilian town in 2016 (n = 329). Toothache was assessed through a structured questionnaire using the question: “In the last six months, have you experienced a toothache?” (yes/no). The main exposures consisted of six validated questions about negligence and six about physical punishment, both with three potential answers: Always (2 points), sometimes (1 point) or never (0 points). Logistic regression models were fitted to estimate the association between paternal physical punishment/neglect and toothache, adjusted for sex, age, family equivalent income and parents' level of education.ResultsThirty‐seven percent of the children reported no physical punishment, while 19% reported no negligence. The odds ratio (OR) of toothache for every 1 point increase on the abuse or negligence scale was OR = 1.27 (95% Confidence Intervals (CI) = 1.08–1.50) and OR = 1.10 (95% CI = 0.96–1.26), respectively. If the child's mother had started and/or finished university, the OR of toothache is lower.ConclusionsPaternal physical punishment is associated with toothache.
The Role of Nurse Implementation Scientists in Leading Health System Transformation in Atlantic Canada and Beyond: A Discussion Paper
Authors: Campbell Alyson , Cassidy Christine 
Published: December 2024

ABSTRACTAimTo discuss and provide examples of how nurse implementation scientists can support health system transformation.DesignDiscussion paper.MethodsUsing Prince Edward Island's health system strategic plan as a case exemplar, selected key priorities in the strategic plan were mapped with examples and discussion of how nurse implementation scientists can support health system transformation on Prince Edward Island and beyond.ConclusionAccelerating the development and delivery of evidence‐informed services that support health system transformation is needed. Nurse implementation scientists are ideally positioned to lead these efforts. Appropriate resourcing and compensation are essential to fully embrace nurse implementation scientist roles, collaboration, and buy‐in from health system leaders.Implications for NursingPractical examples of how nurse implementation scientists can lead health system transformation in a rigorous, evidence‐informed way are identified.ImpactLiterature providing examples of how nurse implementation scientists can make meaningful impacts within health systems, particularly in rural contexts, is limited. Nurse implementation scientists are ideally positioned to collaborate with and lead health system transformation by virtue of their knowledge, skills, qualifications and experience. Implications of this work extend beyond nursing to other health disciplines, health organisations, government leaders, researchers and populations. The discussion and examples provided may be applicable to similar contexts.Patient or Public ContributionNo patient or public contribution.
Impact of Atopic Dermatitis on Adolescents and Families: A Mixed‐Method Systematic Review
Authors: Vicho‐de‐la‐Fuente Noelia , Martinez‐Santos Alba‐Elena , Rodríguez‐González Raquel , Florez Ángeles , Sheaf Greg , Coyne Imelda 
Published: December 2024

ABSTRACTAimsTo summarise the evidence regarding the impact of atopic dermatitis on adolescents and their families as well as their healthcare needs and to propose a nursing care plan based on the findings.DesignMixed‐method systematic review.MethodsTwenty‐four studies were included, of which 19 were quantitative and 5 were qualitative. The quality of the studies was assessed using the Mixed Methods Assessment Tool. The synthesis method used was data‐driven convergent synthesis design.Data SourcesA systematic search was carried out in CINAHL, Embase, MEDLINE, PsycInfo and Web of Science without language restrictions from 1 January 2013 to 30 April 2023.ResultsThe quality of life of adolescents with atopic dermatitis and their families are impaired. The more the severity of the condition, the greater the impact for them and their families. Atopic dermatitis impacts adolescents' sleep (due to itching), behaviour, mental well‐being, social and school life. Likewise, parents' sleep, free time, interpersonal relationships and work life are affected by caring for their adolescents.ConclusionAdolescents and their families encounter numerous challenges managing and living with atopic dermatitis on a daily basis. The condition has a widespread impact on adolescents and parents' quality of life across home, work and school settings. In the family, there was also an alteration in the functioning and relationships between its members.Implications for the Profession and/or Patient CareThis review reveals the burden of atopic dermatitis for adolescents and families and the need for comprehensive support. Greater awareness among healthcare professionals of the impacts may help promote an evidence‐based approach that supports the whole family. Based on these findings, we propose a nursing care plan based on the NANDA taxonomy to promote better healthcare provision for adolescents and families.Reporting MethodThis review adheres to PRISMA guidelines.Patient or Public ContributionNo patient or public contribution.Review Registration (PROSPERO According to JAN Guidelines)CRD42023435352.
Exploring the Utility of a Machine Learning Approach with Mobile‐Based Cognitive Function Tasks for Detecting Depression
Authors: Takeshige Momoka , Oka Taiki , Ohwan Mai , Hirai Kei 
Published: December 2024

AbstractSelf‐report questionnaires, used for detecting major depressive disorder (MDD) in daily life, may incur biases stemming from social desirability and repetitive answers. Though detection based on mobile sensing was being developed recently, it cannot sufficiently promote self‐help action due to the characteristics of passive feedback. Thus, an active self‐monitoring and feedback system is crucial for individuals to recognize and address their malfunctions. In this study, we proposed to predict changes in MDD severity using cognitive tasks monitored on mobile devices. An online survey was conducted to evaluate the severity, incorporating cognitive tasks such as Navon task, Go/No‐go task, and n‐back task, along with the Quick Inventory of Depressive Symptomatology. Participants completed the survey three times on their mobile devices. The analysis included data from 75 participants, including 21 participants whose MDD score increased by at least one point during the second and third surveys; the first survey was excluded to avoid confounding effects. A random forest classifier was employed for classifying participants whose depression has and has not worsened. The learned model achieved modest accuracy (68.3%) with a significant mean area under the curve of 0.59 (t(9) = 2.98, p = .016, dz = 0.94), suggesting the potential to predict depressive states based on cognitive domains. Moreover, working memory and attentional inhibition functions contributed to predicting the severity change mostly. Though improvements are required to reduce false negatives for practical applications, our result suggests that MDD aggravation could be assessed by mobile cognitive tasks.
Gynoecial diversity in the Annonaceae and the evolution of functional traits that overcome the limitations of apocarpy
Authors: Chen Yanwen , Chen Junhao , Xue Bine , Yang Bin , Thomas Daniel C. , Saunders Richard M. K. 
Published: December 2024

AbstractMost species in the early divergent angiosperm family Annonaceae are apocarpous, with very diverse gynoecial morphologies. Although several Annonaceae genera with apocarpous flowers are known to possess an extragynoecial compitum (EGC) that enables intercarpellary pollen‐tube growth to enhance fertilization success, the occurrence of EGC across the whole family remains obscure. Twenty Annonaceae species from all four subfamilies (Anaxagoreoideae, Ambavioideae, Annonoideae, and Malmeoideae) are examined here, with anatomical evidence revealing the occurrence of stigmatic exudate‐mediated suprastylar EGC in all four subfamilies. Histological and ontogenetic studies furthermore indicate that trichomes in Cananga and Drepananthus form a confluent zone that connects adjacent stigmas, providing a structural premise for suprastylar EGC. Infrastylar EGC are reported in the Annonaceae for the first time in several genera, including Artabotrys, Annona, and Miliusa, associated with the opening on the ovary ventral groove and/or basal placentation. In addition to the sister genera Isolona and Monodora that are clearly syncarpous, flowers of the distantly related genus Cyathocalyx with a unicarpellate gynoecium have also been hypothesized to be syncarpous. Evidence of carpel vasculature and primordium development does not support that the solitary Cyathocalyx carpel is originated from carpel fusion, however, although the increased number of ovules renders it functionally similar to syncarpy. Gynoecial features, including the extensive occurrence of EGC and the increased number of ovules per carpel (consonant with reduction to a solitary carpel) in Cyathocalyx, may have evolved to overcome limitations associated with apocarpy and possibly contribute to the reproductive success and diversification of the family.
Genomic‐Guided Conservation Actions to Restore the Most Endangered Conifer in the Mediterranean Basin
Authors: del Valle José Carlos , Arista Montserrat , Benítez‐Benítez Carmen , Ortiz Pedro Luis , Jiménez‐López Francisco J. , Terrab Anass , Balao Francisco 
Published: December 2024

ABSTRACTSpecies with extremely small population sizes are critically endangered because of reduced genetic diversity, increased inbreeding and hybridisation threats. Genomic tools significantly advance conservation by revealing genetic insights into endangered species, notably in monitoring frameworks. Sicilian fir (Abies nebrodensis) is the most endangered conifer in Europe with only 30 adult trees in an 84‐ha area. Using 20,824 SNPs from RAD‐seq, employing genome assembly and a custom 120 SNP‐array, we evaluated genetic diversity, mating patterns, and effective population size in adult trees, 118 natural seedlings, and 2064 nursery seedlings from past conservation actions. We assessed introgression from neighbouring non‐native fir plantations (~6%) and established an intra‐population assisted gene flow (AGF) program selecting the most genetically dissimilar individuals and investigating the outcome through simulations. Genomic analysis unveiled significant genetic diversity among adult Sicilian firs, comparable to non‐endangered Mediterranean firs with larger populations. However, the genetic diversity of the forthcoming generation declined due to high self‐fertilisation, leading to marked inbreeding (FIS = 0.38) and an alarmingly low effective population size (Ne = 6). Nursery seedling monitoring revealed similar selfing rates and introgression (~2%) from non‐native firs. Although intra‐population AGF could help to mitigate genetic loss, it may not alleviate the species vulnerability to imminent environmental challenges, perpetuating the risk of an extinction vortex. Hence, investigating the impact of Sicilian fir population decline and selfing on inbreeding depression, along with exploring the potential of hybrids for genetic load alleviation and future adaptation, is crucial for effective conservation strategies.