bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prescriber continuity and medication availability in older adults with cardiometabolic conditions
Authors: Maciejewski Matthew L , Hammill Bradley G , Voils Corrine I , Ding Laura , Bayliss Elizabeth A , Curtis Lesley H , Wang Virginia 
Published: February 2018

Background: Many older adults have multiple conditions and see multiple providers, which may impact their use of essential medications. Objective: We examined whether the number of prescribers of these medications was associated with the availability of medications, a surrogate for adherence, to manage diabetes, hypertension or dyslipidemia. Methods: A retrospective cohort of 383,145 older adults with diabetes, hypertension or dyslipidemia in the US Medicare program living in 10 states. The association between the number of prescribers of cardiometabolic medications in 2010 and medication availability (proportion of days with medication on hand) in 2011 was estimated via logistic regression, controlling for patient demographic characteristics and chronic conditions. Results: Medicare beneficiaries with diabetes, hypertension and/or dyslipidemia had an average of five chronic conditions overall, obtained 10–12 medications for all conditions and most often had one prescriber of cardiometabolic medications. In adjusted analyses, the number of prescribers was not significantly associated with availability of oral diabetes agents but having more prescribers is associated with increased medication availability in older Medicare beneficiaries with dyslipidemia or hypertension. Conclusion: The incremental addition of new prescribers may be clinically reasonable for complex patients but creates the potential for coordination problems and informational discontinuity over time. Health systems may want to identify complex patients with multiple prescribers to minimize care fragmentation.
Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors?
Authors: Gade Malene R , Goukasian Irina , Panduro Nathalie , Kamby Claus , Nilas Lisbeth , Tuxen Malgorzata K , Bjerrum Lars 
Published: February 2018

Objective To estimate the prevalence of vaginal symptoms in postmenopausal women with breast cancer exposed to aromatase inhibitors, and to investigate if the risk of vaginal symptoms is associated with previous episodes of bacterial vaginosis. Methods Patients from Rigshospitalet and Herlev University Hospital, Denmark, were identified through the register of Danish Breast Cancer Cooperation Group and 78 patients participated in the study. Semiquantitave questionnaires and telephone interview were used to assess the prevalence of vaginal symptoms and previous episode(s) of bacterial vaginosis. Multivariable logistic regression models were used to assess the association between vaginal symptoms and previous episodes of bacterial vaginosis. Results Moderate to severe symptoms due to vaginal itching/irritation were experienced by 6.4% (95% CI: 2.8–14.1%), vaginal dryness by 28.4% (95% CI: 19.4–39.5%), and dyspareunia by 23.1% (95% CI: 11.0–42.1%). Patients with earlier episodes of bacterial vaginosis had an increased risk of vaginal dryness when exposed to a treatment with an aromatase inhibitor, adjusted OR 5.5 (95% CI 1.3–21.6). Conclusion A considerable number of patients exposed to aromatase inhibitor have vaginal symptoms and the risk is highest among patients with earlier episodes of bacterial vaginosis.
Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway
Authors: Yuan Gangjun , Chen Xin , Liu Zhuowei , Wei Wensu , Shu Qinghai , Abou-Hamdan Hussein , Jiang Lijuan , Li Xiangdong , Chen Rixin , Désaubry Laurent , Zhou Fangjian , Xie Dan 
Published: February 2018

Abstract
Background
Prohibitin 1 (PHB) is a potential target for the treatment of urothelial carcinoma of the bladder (UCB). FL3 is a newly synthesized agent that inhibits cancer cell proliferation by targeting the PHB protein; however, the effect of FL3 in UCB cells remains unexplored.

Methods
FL3 was identified to be a potent inhibitor of UCB cell viability using CCK-8 (cell counting kit-8) assay. Then a series of in vitro and in vivo experiments were conducted to further demonstrate the inhibitory effect of FL3 on UCB cell proliferation and to determine the underlying mechanisms.

Results
FL3 inhibited UCB cell proliferation and growth both in vitro and in vivo. By targeting the PHB protein, FL3 inhibited the interaction of Akt and PHB as well as Akt-mediated PHB phosphorylation, which consequently decreases the localization of PHB in the mitochondria. In addition, FL3 treatment resulted in cell cycle arrest in the G2/M phase, and this inhibitory effect of FL3 could be mimicked by knockdown of PHB.
Through the microarray analysis of mRNA expression after FL3 treatment and knockdown of PHB, we found that the mRNA expression of the growth arrest and DNA damage-inducible alpha (GADD45α) gene were significantly upregulated. When knocked down the expression of GADD45α, the inhibitory effect of FL3 on cell cycle was rescued, suggesting that FL3-induced cell cycle inhibition is GADD45α dependent.

Conclusion
Our data provide that FL3 inhibits the interaction of Akt and PHB, which in turn activates the GADD45α-dependent cell cycle inhibition in the G2/M phase.
Understanding Men’s Perceptions of Human Papillomavirus and Cervical Cancer Screening in Kampala, Uganda
Authors: Moses Erin , Pedersen Heather N. , Wagner Emily C. , Sekikubo Musa , Money Deborah M. , Ogilvie Gina S. , Mitchell-Foster Sheona M. 
Published: February 2018

Purpose This preliminary study explores Ugandan men’s knowledge and attitudes about human papillomavirus (HPV), cervical cancer, and screening. Methods A local physician led an education session about cervical cancer for 62 men in Kisenyi, Kampala in Uganda. Trained nurse midwives administered surveys to assess knowledge and attitudes before and after the education session. Results From the pre-education survey, only 24.6% of men had heard of HPV previously, and 59% of men had heard of cervical cancer. Posteducation, 54.5% of men believed only women could be infected with HPV and 32.7% of men believed antibiotics could cure HPV. Despite their limited knowledge, 98.2% of men stated they would support their partners to receive screening for cervical cancer, and 100% of men surveyed stated they would encourage their daughter to get the HPV vaccine if available. Conclusions Knowledge of HPV and cervical cancer among Ugandan men is low. Even after targeted education, confusion remained about disease transmission and treatment. Ongoing education programs geared toward men and interventions to encourage spousal communication about reproductive health and shared decision making may improve awareness of cervical cancer prevention strategies.
Subtraction CT angiography in head and neck with low radiation and contrast dose dual-energy spectral CT using rapid kV-switching technique
Authors: Ma Guangming , YU Yong , Duan Haifeng , Dou Yuequn , Jia Yongjun , Zhang Xirong , Yang Chuangbo , Chen Xiaoxia , Han Dong , Guo Changyi , He Taiping 
Published: February 2018

Objective:
To investigate the application of low radiation and contrast dose spectral CT angiology using rapid kV-switching technique in the head and neck with subtraction method for bone removal.

Methods:
This prospective study was approved by the local ethics committee. 64 cases for head and neck CT angiology were randomly divided into Groups A (n = 32) and B (n = 32). Group A underwent unenhanced CT with 100 kVp, 200 mA and contrast-enhanced CT with spectral CT mode with body mass index-dependent low dose protocols. Group B used conventional helical scanning with 120 kVp, auto mA for noise index of 12 HU (Hounsfield unit) for both the unenhanced and contrast-enhanced CT. Subtraction images were formed by subtracting the unenhanced images from enhanced images (with the 65 keV-enhanced spectral CT image in Group A). CT numbers and their standard deviations in aortic arch, carotid arteries, middle cerebral artery and air were measured in the subtraction images. The signal-to-noise ratio and contrast-to-noise ratio for the common and internal carotid arteries and middle cerebral artery were calculated. Image quality in terms of bone removal effect was evaluated by two experienced radiologists independently and blindly using a 4-point system. Radiation dose and total iodine load were recorded. Measurements were statistically compared between the two groups.

Results:
The two groups had same demographic results. There was no difference in the CT number, signal-to-noise and contrast-to-noise ratio values for carotid arteries and middle cerebral artery in the subtraction images between the two groups (p &gt; 0.05). However, the bone removal effect score [median (min-max)] in Group A [4 (3–4)] was rated better than in Group B [3 (2–4)] (p &lt; 0.001), with excellent agreement between the two observers (κ &gt; 0.80). The radiation dose in Group A (average of 2.64 mSv) was 57% lower than the 6.18 mSv in Group B (p &lt; 0.001). The total iodine intake in Group A was 13.5g, 36% lower than the 21g in Group B.

Conclusion:
Spectral CT imaging with rapid kV-switching in the subtraction angiography in head and neck provides better bone removal with significantly reduced radiation and contrast dose compared with conventional subtraction method.

Advances in knowledge:
This novel method provides better bone removal with significant radiation and contrast dose reduction compared with the conventional subtraction CT, and maybe used clinically to protect the thyroid gland and ocular lenses from unnecessary high radiation.
Get with the Program: Software-Driven Innovation in Traditional Manufacturing
Authors: Branstetter Lee G. , Drev Matej , Kwon Namho 
Published: February 2018

This paper documents the increasing importance of software for successful innovation in manufacturing sectors well beyond the traditional definition of electronics and information technology. Using panel data for 229 publicly listed firms from 18 countries across four manufacturing industries over the period 1981–2005, we find significant variation across firms in the software intensity of their innovative activity. Firms that exhibit a higher level of software intensity generate more patents per R&D dollar, and their investment in R&D is more highly valued by equity markets.Data and the online appendix are available at https://doi.org/10.1287/mnsc.2017.2960 .This paper was accepted by Anandhi Bharadwaj, information systems.
Advances in the Diagnosis and Management of Cystic Fibrosis in the Genomic Era
Authors: Wiencek Joesph R , Lo Stanley F 
Published: February 2018

AbstractBACKGROUNDCystic fibrosis (CF) is a complex autosomal recessive disease that continues to present unique diagnostic challenges. Because CF was first described in 1938, there has been a substantial growth of genetic and phenotypic information about the disorder. During the past few years, as more evidence has become available, a consortium of international experts determined that the 2008 guidelines from the CF Foundation needed to be reviewed and updated.CONTENTThe goal of this review is to highlight the latest advances in CF multidisciplinary care, together with the recent updates to the 2017 CF Foundation diagnostic guidelines.SUMMARYData from newborn screening programs, patient registries, clinical databases, and functional research have led to a better understanding of the CF transmembrane conductance regulator (CFTR) gene. Recent consensus guidelines have provided recommendations for clinicians and laboratorians to better assist with interpretation of disease status and related CF mutations. The highly recommended Clinical and Functional Translation of CFTR project should be the first resource in the evaluation of disease severity for CF mutations. Screen-positive newborns and patients with high clinical suspicion for CF are always recommended to undergo confirmatory sweat chloride testing with interpretations based on updated reference intervals. Every patient diagnosed with CF should receive genotyping, as novel molecular therapies are becoming standard of practice. The future of CF management must consider healthcare system disparities as CF transitions from a historically childhood disease to a predominantly adult epidemic.
Investigating the Effect of Glass Ion Release on the Cytocompatibility, Antibacterial Eflcacy and Antioxidant Activity of Y2O3 / CeO2 doped SiO2-SrO-Na2O glasses
Authors: Placek L. M. , Keenan T. J. , Coughlan A. , Wren A. W. 
Published: February 2018

AbstractThe effect on ion release and cytocompatibility of Yttrium (Y) and Cerium (Ce) are investigated when substituted for Sodium (Na) in a 0.52SiO2-0.24SrO-0.24-Na2OMOglass series (where MO= Y2O3or CeO2). Glass leaching was evaluated through pH measurements and Inductive Coupled Plasma-Optical Emission Spectrometry (ICP-OES) analysiswhere the extract pH increased during incubation (11.2 - 12.5). Ion release of Silicon (Si), Na and Strontium (Sr) from the Con glass was at higher than that of glasses containing Y or Ce, and reached a limit after 1 day. Ion release from Y and Ce containing glasses reached a maximum of 1800 μg/mL, 1800 μg/mL, and 10 μg/mL for Si, Na, and Sr, respectively. Release of Y and Cewas below the ICP- OES detection limit <0.1 μg/mL. Cell viability of both L929 fibroblasts and MC3T3 osteoblasts decreased for Con, LY, and LCe extracts; HY extracts did not significantly decrease cell viability while YCe and HCe saw concentrationdependent viability decrease (20%, 33% extract concentrations). Bacterial studies saw Con and LCe eliminating >75% of bacteria at a 9% extract concentration. Antioxidant capacity (mechanism for neuroprotection) was evaluated using the ABTS assay. All glasses had inherent radical oxygen species (ROS) scavenging capability with Con reaching 9.5 mMTE.
Quantification of anthropogenic metabolism using spatially differentiated continuous MFA
Authors: Schiller Georg , Gruhler Karin , Ortlepp Regine 
Published: February 2018

AbstractCoefficient-based, bottom-up material flow analysis is a suitable tool to quantify inflows, outflows and stock dynamics of materials used by societies, and thus can deliver strategic knowledge needed to develop circular economy policies. Anthropogenic stocks and flows are mostly of bulk nonmetallic mineral materials related to the construction, operation and demolition of buildings and infrastructures. Consequently, it is important to be able to quantify circulating construction materials to help estimate the mass of secondary materials which can be recovered such as recycled aggregates (RA) for fresh concrete in new buildings. Yet as such bulk materials are high volume but of low unit value, they are generally produced and consumed within a region. Loops are thus bounded not only by qualitative and technical restrictions but also spatially to within regions. This paper presents a regionalized continuous MFA (C-MFA) approach taking account of these restrictions of local consumption, quality standards and technical limitations, illustrated using the example of Germany. Outflows and inflows of stocks are quantified at county level and generalized by regional type, considering demand and supply for recycled materials. Qualitative and technical potentials of recycling loops are operationalized by defining coefficients to reflect waste management technologies and engineering standards. Results show that 48% of outflows of concrete and bricks are suitable for high-quality recycling, while 52% of outflows do not fulfill the quality requirement and must be recovered or disposed of elsewhere. The achievable inflow to RA is limited by the building activity as well as the requirements of the construction industry, e.g. the RA fraction of fresh concrete must not exceed 32%. In addition, there exist spatial disparities in construction across the country. In Germany, such disparities mean that there will be a shortfall in RA of 6.3 Gt by the year 2020, while the technically available but unusable RA (due to a regional mismatch of potential supply and demand) will total 3.2 Gt. Comprehensive recycling strategies have to combine high-quality recycling with other lower-grade applications for secondary raw materials. Particularly in the case of building materials, essential constraints are not only technical but also local conditions of construction and demolition. These interrelations should be identified and integrated into a comprehensive system to manage the social metabolism of materials in support of circular economy policies.
Material for Compact Hydrogen Cartridges Based on Commercial Aluminium Alloys Activated by Ga-In Eutectics
Authors: Nizovskii A.I. , Kulikov A.V. , Trenikhin M.V. , Bukhtiyarov V.I. 
Published: February 2018

AbstractReactivity of commercial aluminium alloys activated by the liquid eutectic alloy (76 wt.% of Ga, 24 wt.% of In, t
Nobody Knows My Name: The Masquerade of Mourning in the Early 1980s Artistic Productions of Michael Jackson and Prince
Authors: Pochmara Anna , Wierzchowska Justyna 
Published: February 2018

Abstract
The article analyses Michael Jackson’s album Thriller and Prince’s movie Purple Rain. We explore their camp aesthetics and their recasting of the cultural representations of the black male. Jackson’s and Prince’s performative personas are both liberatory and burdened with the received cultural scripts of black masculinity. We claim that their employment of camp is political rather than escapist and depoliticized. Camp serves them as a platform to mourn the cultural displacement of the black male body in a postslavery America. In particular, the two artists distance themselves from the extensive ideological and physical pressures exerted on the black male body in the early 1980s. As a result, their performances are complexly de-Oedipalized. Prince in Purple Rain refuses to assume the patriarchal position of the Father. Analogously, Jackson fashions himself as a Peter Pan-like eternal adolescent who never makes his final identification as either heterosexual or LGBTQ desiring agent. In the coda to the article, we reach beyond the 1980s to explore a more flexible approach to camp in the artistic output of twenty-first-century African American performers of Queercore and Afrofuturist scenes, which were partially enabled by Jackson’s and Prince’s performances.
Design and synthesis of hierarchical mesoporous WO3-MnO2 composite nanostructures on carbon cloth for high-performance supercapacitors
Authors: Shinde Pragati A. , Lokhande Vaibhav C. , Patil Amar M. , Ji Taeksoo , Lokhande Chandrakant D. 
Published: February 2018

AbstractTo enhance the energy density and power performance of supercapacitors, the rational design and synthesis of active electrode materials with hierarchical mesoporous structure is highly desired. In the present work, fabrication of high-performance hierarchical mesoporous WO
Group-groupoid actions and liftings of crossed modules
Authors: Mucuk Osman , Şahan Tunçar 
Published: February 2018

Abstract
The aim of this paper is to define the notion of lifting via a group morphism for a crossed module and give some properties of this type of liftings.
Further, we obtain a criterion for a crossed module to have a lifting crossed module.
We also prove that the category of the lifting crossed modules of a certain crossed module is equivalent to the category of group-groupoid actions on groups, where the group-groupoid corresponds to the crossed module.
On the geometrical properties of hypercomplex four-dimensional Lie groups
Authors: Nasehi Mehri , Aghasi Mansour 
Published: February 2018

Abstract
In this paper, we first classify Einstein-like metrics on hypercomplex four-dimensional Lie groups. Then we obtain the exact form of all harmonic maps on these spaces. We also calculate the energy of an arbitrary left-invariant vector field X on these spaces and determine all critical points for their energy functional
restricted to vector fields of the same length. Furthermore, we give a complete and explicit description of all totally geodesic hypersurfaces of these spaces. The existence of Einstein hypercomplex four-dimensional Lie groups and the non-existence of non-trivial left-invariant Ricci and Yamabe solitons on these spaces are also proved.
Optimization of 2‑Stage Turbocharged Gas SI Engine Under Steady State Operation
Authors: Vítek Oldřich , Macek Jan , Klíma Jiří , Vacek Martin 
Published: February 2018

Abstract
The proposed paper deals with an optimization of a highly-turbocharged large-bore gas SI engine. Only steady state operation (constant engine speed and load) is considered. The paper is mainly focused on theoretical potential of 2-stage turbocharging concept in terms of performance and limitation. The results are obtained by means of simulation using complex 0-D/ 1-D engine model including the control algorithm. Different mixture composition concepts are considered to satisfy different levels of NOx limit - fresh air mixed with external cooled EGR is supposed to be the right approach while optimal EGR level is to be found. Considering EGR circuit, 5 different layouts are tested to select the best design. As the engine control is relatively complex (2-sage turbocharger group, external EGR, compressor blow-by, controlled air excess), 5 different control means of boost pressure were considered. Each variant based on above mentioned options is optimized in terms of compressor/turbine size (swallowing capacity) to obtain the best possible BSFC. The optimal variants are compared and general conclusions are drawn.
Evaluation of the Predictive Capabilities of a Phenomenological Combustion Model for Natural Gas SI Engine
Authors: Toman Rastislav , Macek Jan 
Published: February 2018

Abstract
The current study evaluates the predictive capabilities of a new phenomenological combustion model, available as a part of the GT-Suite software package. It is comprised of two main sub-models: 0D model of in-cylinder flow and turbulence, and turbulent SI combustion model. The 0D in-cylinder flow model (EngCylFlow) uses a combined K-k-ε kinetic energy cascade approach to predict the evolution of the in-cylinder charge motion and turbulence, where K and k are the mean and turbulent kinetic energies, and ε is the turbulent dissipation rate. The subsequent turbulent combustion model (EngCylCombSITurb) gives the in-cylinder burn rate; based on the calculation of flame speeds and flame kernel development. This phenomenological approach reduces significantly the overall computational effort compared to the 3D-CFD, thus allowing the computation of full engine operating map and the vehicle driving cycles. Model was calibrated using a full map measurement from a turbocharged natural gas SI engine, with swirl intake ports. Sensitivity studies on different calibration methods, and laminar flame speed sub-models were conducted. Validation process for both the calibration and sensitivity studies was concerning the in-cylinder pressure traces and burn rates for several engine operation points achieving good overall results.
Experimental and theoretical study of 1, 4-naphthoquinone based dye in dye-sensitized solar cells using ZnO photoanode
Authors: Shinde Dnyaneshwar , Tambade Popat , Pathan Habib , Gadave Kisan 
Published: February 2018

AbstractA dye-sensitized solar cell (DSSC) was assembled using a dye 4-(3-chloro-1, 4-dioxo-1, 4-dihydronaphthalen-2-ylamino) benzoic acid with ZnO as a photoanode. It was synthesized using 2, 3-dichloro 1, 4-naphthoquinone and p-amino benzoic acid. The spectral features of the dye were analyzed in ethanol using experimental and computational methods. The theoretical investigations revealed that the synthesized dye may act as a sensitizer in DSSCs. The photoelectrochemical performance was tested under direct sunlight using a sandwich type DSSC. The photovoltaic data of the dye adsorbed on ZnO films indicated thepower conversion efficiency of 1.07 % under sunlight with a light intensity of 39 mW·cm-2.