bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biocomputing for Portable, Resettable, and Quantitative Point‐of‐Care Diagnostics: Making the Glucose Meter a Logic‐Gate Responsive Device for Measuring Many Clinically Relevant Targets
Authors: Zhang Jingjing , Lu Yi 
Published: June 2018

AbstractIt is recognized that biocomputing can provide intelligent solutions to complex biosensing projects. However, it remains challenging to transform biomolecular logic gates into convenient, portable, resettable and quantitative sensing systems for point‐of‐care (POC) diagnostics in a low‐resource setting. To overcome these limitations, the first design of biocomputing on personal glucose meters (PGMs) is reported, which utilizes glucose and the reduced form of nicotinamide adenine dinucleotide as signal outputs, DNAzymes and protein enzymes as building blocks, and demonstrates a general platform for installing logic‐gate responses (YES, NOT, INHIBIT, NOR, NAND, and OR) to a variety of biological species, such as cations (Na+), anions (citrate), organic metabolites (adenosine diphosphate and adenosine triphosphate) and enzymes (pyruvate kinase, alkaline phosphatase, and alcohol dehydrogenases). A concatenated logical gate platform that is resettable is also demonstrated. The system is highly modular and can be generally applied to POC diagnostics of many diseases, such as hyponatremia, hypernatremia, and hemolytic anemia. In addition to broadening the clinical applications of the PGM, the method reported opens a new avenue in biomolecular logic gates for the development of intelligent POC devices for on‐site applications.
Kinetic Study of the Scavenging Reaction of the Aroxyl Radical by Eight Kinds of Vegetable Oils in Solution
Authors: Mukai Kazuo , Bandoh Yuki , Ito Junya , Kobayashi Eri , Nakagawa Kiyotaka , Nagaoka Shin‐ichi 
Published: June 2018

AbstractA detailed kinetic study was performed for the reaction of the aroxyl radical (ArO•) with eight vegetable oils 1–8, which contain different concentrations of α‐, β‐, γ‐, and δ‐tocopherols and ‐tocotrienols (‐Tocs and ‐Toc‐3s). The second‐order rate constants (ks) and aroxyl radical absorption capacity (ARAC) values for the reaction of ArO• with vegetable oils 1–8 (rice bran 1, perilla 2, rapeseed 3, safflower 4, grape seed 5, sesame 6, extra virgin olive 7, and olive oils 8) were measured in ethanol/chloroform/D2O (50:50:1, v/v/v) solution at 25 °C using stopped‐flow spectrophotometry. The ks value (16.1 × 10−3 L g−1 s−1) of rice bran oil 1 with the highest activity was 8.0 times larger than that (2.02 × 10−3) of olive oil 8 with the lowest activity. The concentrations (in mg 100 g−1) of α‐, β‐, γ‐, and δ‐Tocs and ‐Toc‐3s contained in the vegetable oils 1–8 were determined using high performance liquid chromatography‐mass spectrometry/mass spectrometry (HPLC‐MS/MS). From these results, it was clarified that the ArO•‐scavenging rates (ks) (i.e., the relative ARAC value) obtained for the vegetable oils 1–8 may be well explained as the sum of the product of the rate constant () and the concentration ([AOH‐i]/105) of AOH‐i (Tocs and Toc‐3s) included in vegetable oils. The results suggest that the ARAC assay method might be used in the evaluation of antioxidant activity of general food extracts.
Recent advances in metabolic engineering of Corynebacterium glutamicum as a potential platform microorganism for biorefinery
Authors: Baritugo Kei‐Anne G. , Kim Hee Taek , David Yokimiko C. , Choi Jong Hyun , Choi Jong‐il , Kim Tae Wan , Park Chulhwan , Hong Soon Ho , Na Jeong‐Geol , Jeong Ki Jun , Joo Jeong Chan , Park Si Jae 
Published: June 2018

AbstractThe fermentative production of platform chemicals in biorefineries is a sustainable alternative to current petroleum‐refining processes. Industrial microorganisms, such as Escherichia coli, Saccharomyces cerevisiae, and Corynebacterium glutamicum, have been engineered as microbial cell factories that are able to utilize biomass for the production of value‐added platform chemicals and polymers. Compared to E. coli and S. cerevisiae, C. glutamicum displays weak carbon catabolite repression and can co‐utilize mixed sugars as carbon sources, without any significant growth retardation. Pathways for the utilization of alternative carbon sources, such as d‐xylose and l‐arabinose from lignocellulosic biomass, lactose and galactose from whey, glycerol from biodiesel, and methanol from natural gas refineries, have been evaluated for chemical production. However, the application of C. glutamicum in biorefineries is limited because it does not secrete hydrolases for the efficient utilization of cellulose, xylan, and starch from lignocellulosic and starch biomass. To solve the limitation, C. glutamicum has been engineered for the consolidated bioprocessing of biomass by the heterologous expression of amylolytic and cellulolytic enzymes. Recently, C. glutamicum has been extensively engineered for polyamide monomer production owing to its ability to produce l‐lysine and l‐glutamate. This review summarizes recent advances in the development of C. glutamicum strains that can utilize renewable biomass resources for the production of industrially important chemicals. It highlights recent progress in metabolic engineering for the production of polyamide monomers. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd
Peripheral artery disease: How do genes and pharmacology interplay?
Authors: Shatila Wassim , Krajcer Zvonimir 
Published: June 2018

Key Points

In patients with peripheral artery disease, high on‐treatment platelet reactivity (HoTPR) might be associated with worse outcomes for those taking clopidogrel, but not for those taking aspirin.
Certain genetic polymorphisms might account for HoTPR.
Current literature supports the importance of antiplatelet therapy in treating patients with PAD with clopidogrel, aspirin, or both.
Percutaneous neonatal carotid access for interventional catheterization
Authors: Lucas Victor “Sam” , Crittendon Ivory 
Published: June 2018

Key Points

Neonatal percutaneous carotid access is a safe technique that compares favorably to neonatal surgical carotid access.
Mid‐term ultrasound and angiographic follow after percutaneous carotid access shows 100% vessel patency rate with no severe stenoses or aneurysms detected.
Mild stenosis (<12%) is frequent at follow up (35%), the clinical significance of which is unknown.
Radiation safety with dose reduction technology: The buck stops at zero dose
Authors: Bang Vigyan V. , Levy Michael S. 
Published: June 2018

Key Points

Exposure to ionizing radiation in cardiovascular imaging and its adverse impact on health is a growing concern.
Cath lab imaging dose‐reduction technology is an effective way to reduce patient and operator radiation dose.
More clinical trials and studies such as this one are needed to assess the short‐and long‐term impact of this important technology.
Counting and Sizing of Single Vesicles/Liposomes by Electrochemical Events
Authors: Liu Yang , Xu Cong , Yu Ping , Chen Xuwei , Wang Jianhua , Mao Lanqun 
Published: June 2018

AbstractThe analysis of single entities in a liquid phase by electrochemical events has received much attention in recent years due to innovations and advances in exciting electrochemical methods as well as precise manufacturing techniques. Vesicles, as a special type of entity, play an important role in biological systems. However, the soft character and complex surface chemistry of vesicles present inherent challenges for single‐vesicle analysis. This minireview mainly focuses on the theory and recent progress of single‐vesicle/liposome analysis based on electrochemical events. Three different analytical principles, namely, pore/channel translocation, microelectrode impact and nanopipette collision, are reviewed and expatiated. Not only the capabilities for size determination, vesicle/liposome counting and the electroactive quantification of the contents within vesicles/liposomes but also the specificities of vesicle/liposome or entity‐pore/electrode interactions reflected in translocation or collision events are discussed in detail. Moreover, the advantages and disadvantages of each method of single‐vesicle analysis are discussed in this minireview.
Boosting Self‐Assembly Diversity in the Solid‐State by Chiral/Non‐Chiral ZnII‐Porphyrin Crystallization
Authors: Qian Wenjie , González‐Campo Arántzazu , Pérez‐Rodríguez Ana , Rodríguez‐Hermida Sabina , Imaz Inhaz , Wurst Klaus , Maspoch Daniel , Ruiz Eliseo , Ocal Carmen , Barrena Esther , Amabilino David B. , Aliaga‐Alcalde Núria 
Published: June 2018

AbstractA chiral ZnII porphyrin derivative 1 and its achiral analogue 2 were studied in the solid state. Considering the rich molecular recognition of designed metalloporphyrins 1 and 2 and their tendency to crystallize, they were recrystallized from two solvent mixtures (CH2Cl2/CH3OH and CH2Cl2/hexane). As a result, four different crystalline arrangements (1 a,b and 2 a,b, from 0D to 2D) were obtained. Solid‐state studies were performed on all the species to analyze the role played by chirality, solvent mixtures, and surfaces (mica and HOPG) in the supramolecular arrangements. By means of combinations of solvents and substrates a variety of microsized species was obtained, from vesicles to flower‐shaped arrays, including geometrical microcrystals. Overall, the results emphasize the environmental susceptibility of metalloporphyrins and how this feature must be taken into account in their design.
Host–Guest Binding Hierarchy within Redox‐ and Luminescence‐Responsive Supramolecular Self‐Assembly Based on Chalcogenide Clusters and γ‐Cyclodextrin
Authors: Ivanov Anton A. , Falaise Clément , Abramov Pavel A. , Shestopalov Michael A. , Kirakci Kaplan , Lang Kamil , Moussawi Mhamad A. , Sokolov Maxim N. , Naumov Nikolay G. , Floquet Sébastien , Landy David , Haouas Mohamed , Brylev Konstantin A. , Mironov Yuri V. , Molard Yann , Cordier Stéphane , Cadot Emmanuel 
Published: June 2018

AbstractWater‐soluble salts of anionic [Re6Q8(CN)6]4− (Q=S, Se, Te) chalcogenide octahedral rhenium clusters react with γ‐cyclodextrin (γ‐CD) producing a new type of inclusion compounds. Crystal structures determined through single‐crystal X‐ray diffraction analysis revealed supramolecular host–guest assemblies resulting from close encapsulations of the octahedral cluster within two γ‐CDs. Interestingly, nature of the inner Q ligands influences strongly the host–guest conformation. The cluster [Re6S8(CN)6]4− interacts preferentially with the primary faces of the γ‐CD while the bulkier clusters [Re6Se8(CN)6]4− and [Re6Te8(CN)6]4− exhibit specific interactions with the secondary faces of the cyclic host. Furthermore, analysis of the crystal packing reveals additional supramolecular interactions that lead to 2D infinite arrangements with [Re6S8(CN)6]4− or to 1D “bamboo‐like” columns with [Re6Se8(CN)6]4− and [Re6Te8(CN)6]4− species. Solution studies, using multinuclear NMR methods, ESI‐MS and Isothermal titration calorimetry (ITC) corroborates nicely the solid‐state investigations showing that supramolecular pre‐organization is retained in aqueous solution even in diluted conditions. Furthermore, ITC analysis showed that host–guest stability increases significantly ongoing from S to Te. At last, we report herein that deep inclusion alters significantly the intrinsic physical‐chemical properties of the octahedral clusters, allowing redox tuning and near IR luminescence enhancement.
Host–Guest Chemistry of Carboranes: Synthesis of Carboxylate Derivatives and Their Binding to Cyclodextrins
Authors: Nekvinda Jan , Grüner Bohumír , Gabel Detlef , Nau Werner M. , Assaf Khaleel I. 
Published: June 2018

AbstractPolyhedral carboxymethyl carborane (C2B10H12) derivatives, including mono‐ and disubstituted o‐, m‐, and p‐isomers, have been synthesized. Supramolecular host–guest complexation of these derivatives with cyclodextrins (CDs; namely, α‐, β‐, and γ‐CD) has been investigated in water. The globular structure of the carborane binding moiety and its hydrophobic character qualify it as an ideal recognition site to form stable inclusion complexes with macrocyclic host molecules in aqueous solution. The measured binding affinities for the carborane derivatives were in the millimolar range (Ka=103–104 m−1) with differently sized CDs, and preferential binding to β‐CD.
Self‐Assembly of Three‐Dimensional Zinc‐Doped NiCo2O4 as Efficient Electrocatalysts for Oxygen Evolution Reaction
Authors: Yang Man , Li Yunfeng , Yu Yue , Liu Xianchun , Shi Zhan , Xing Yan 
Published: June 2018

AbstractIn this work, a series of three‐dimensional porous flower‐like zinc doped NiCo2O4 (ZNCO) nanostructures with different Zn doping level are successfully prepared by a facile solvothermal process without using any templets. The obtained products are characterized by various techniques, and their electrocatalytic performances are also assessed by the oxygen evolution reaction (OER). According to the electrochemical characterization, it is demonstrated that ZNCO‐0.15 (i.e., Zn0.15Ni0.85Co2O4) nanoflowers show a lower overpotential, smaller Tafel slope, higher electrochemical active surface area (ECSA), as well as a larger turnover frequency (TOF) value than those of Co3O4, NiCo2O4, and ZnCo2O4 nanoflowers, indicating that introduction of an optimal content of zinc ions plays an important role in enhancing electrocatalytic performances for OER. The enhanced OER performance of ZNCO‐0.15 could be attributed to the increased number of active sites (Co3+), accelerated kinetic rate, and promoted conductivity of the catalyst with the incorporation of zinc ions.
Compartmentalized Aqueous–Organic Emulsion for Efficient Biocatalysis
Authors: Zhao Qingcai , Ansorge‐Schumacher Marion B. , Haag Rainer , Wu Changzhu 
Published: June 2018

AbstractThe design and construction of polymeric compartmentalized structures in water have been intensively explored for controllable catalysis, but there is still the challenge of setting up catalytic compartments in organic media. Here, we designed a simple block copolymer, PCL‐b‐PEG‐b‐PCL, to construct a stable and multi‐compartmentalized emulsion in an organic solvent by hand‐shaking. This gentle emulsion preparation allowed a successful encapsulation of vulnerable biocatalysts such as benzaldehyde lyase (BAL) and alcohol dehydrogenase (ADH). The compartmentalization provided the emulsion with an exceptionally large interfacial area that could enhance BAL activity up to 225 times as compared to the traditional biphasic system. Moreover, the system could be easily scaled up due to its facile preparation with low cost. Therefore, our results pave the way for developing compartmentalized structures in solvents for biocatalysis in large‐scale synthetic chemistry.
Photoisomerization of Mono‐Arylated Indigo and Water‐Induced Acceleration of Thermal cis‐to‐trans Isomerization
Authors: Huber Ludwig A. , Mayer Peter , Dube Henry 
Published: June 2018

AbstractThe front cover artwork is provided by Thomas Bartelmann and Henry Dube of the Department of Chemistry, Ludwig‐Maximilians‐Universität Munich (Germany). The image shows photoisomerization of mono‐arylated indigo upon irradiation with red light. Read the full text of the Article at 10.1002/cptc.201700228.
1,4‐Dioxane‐Tuned Catalyst‐Free Methylation of Amines by CO2 and NaBH4
Authors: Guo Zhiqiang , Zhang Bo , Wei Xuehong , Xi Chanjuan 
Published: June 2018

AbstractA catalyst‐free reductive functionalization of CO2 with amines and NaBH4 was developed. The N‐methylation of amines was carried out with CO2 as a C1 building block and 1,4‐dioxane as the solvent. Notably, the six‐electron reduction of CO2 to form the methyl group occurred simultaneously with formation of the C−N bond to give the N‐methylated amine.
Nanostructured FeNi3 Incorporated with Carbon Doped with Multiple Nonmetal Elements for the Oxygen Evolution Reaction
Authors: Liu Zong , Yu Xu , Yu Huaguang , Xue Huaiguo , Feng Ligang 
Published: June 2018

AbstractThe sluggish oxygen evolution reaction (OER) through water electrolysis is still challenging. Herein, a facile approach to fabricate highly efficient nanostructured FeNi3 incorporated on carbon doped with multiple nonmetal elements (FeNi3/M‐C) was prepared by annealing an in situ polymerized metal complex from economical precursors. The temperature dependence of the structure and the catalytic performance for the OER was probed. The best pyrolysis temperature was 800 °C, at which the fabricated material exhibited the highest catalytic performance for the OER. Specifically, an overpotential as low as 246 mV (no IR correction) afforded 10 mA cm−2 with a low Tafel slope of 40 mV dec−1, exceeding that of the best noble‐metal catalyst IrO2 and other similar Fe–Ni alloys. High catalytic efficiency and anticorrosion ability towards the OER were displayed in terms of high specific surface area, rapid kinetics, high stability, and specific activity. The excellent performance was correlated to the structure and the modest graphitization degree of carbon and an appropriate ratio between graphitic and pyridinic N atoms and the synergistic effect between the Fe–Ni alloy active sites and the conducting carbon doped with multiple nonmetal elements. Moreover, as a powder catalyst, it could be applied in a real polymer electrolyte membrane electrolyzer. These results are helpful for understanding the improved catalytic activity and the promotion of the catalytic efficiency of the Fe–Ni alloy materials for the OER.
Daily non‐invasive haemodynamic telemonitoring for efficacy evaluation of MitraClip® implantation in patients with advanced systolic heart failure
Authors: Herrmann Ester , Ecke Andreas , Herrmann Eva , Eissing Nina , Fichtlscherer Stephan , Zeiher Andreas M. , Assmus Birgit 
Published: June 2018

AbstractAimPatients with advanced systolic chronic heart failure frequently suffer from progressive functional mitral regurgitation. We report our initial experience in patients with an implanted pulmonary artery pressure (PAP) sensor, who developed severe mitral regurgitation, which was treated with the MitraClip system. We non‐invasively compared changes in PAP values in patients after MitraClip with PAP changes in patients without MitraClip.Methods and resultsAmong 28 patients with New York Heart Association III heart failure with implanted PAP sensor for haemodynamic telemonitoring from a single centre, four patients (age 66 ± 6 years, left ventricular ejection fraction 21 ± 3%, and cardiac index 1.8 ± 0.3) received a MitraClip procedure and were compared with 24 patients (age 72 ± 8 years, left ventricular ejection fraction 26 ± 9.9%, and cardiac index 2.0 ± 1.0) without MitraClip procedure in a descriptive manner. Ambulatory PAP values were followed for 90 days in both groups. In comparison with the PAP values 4 weeks before MitraClip procedure, PAP was profoundly reduced in all four patients after 30 days (ΔPAPmean −11 ± 5, ΔPAPdiast −7 ± 3 mmHg, P < 0.02) as well as after 90 days (ΔPAPmean −6.3 ± 6, ΔPAPdiast −1 ± 3 mmHg). Reductions in PAP were accompanied by a profound reduction in N terminal pro brain natriuretic peptide as well as clinical and echocardiographic improvement. When analysing the dynamics with a regression model, reductions in all PAP values were significantly greater after MitraClip compared with conservative haemodynamic monitoring (P < 0.001).ConclusionsThe efficacy of the interventional MitraClip procedure on clinical symptoms can be confirmed by haemodynamic telemonitoring. Thus, daily non‐invasive haemodynamic telemonitoring allows, for the first time, for a continuous assessment of the haemodynamic efficacy of novel therapies in patients with chronic heart failure.
Synthesis and Reactivity of Copper(I) Complexes Based on C3‐Symmetric Tripodal HTIM(PR2)3 Ligands
Authors: Smirnova Ekaterina S. , Acuña‐Parés Ferran , Escudero‐Adán Eduardo C. , Jelsch Christian , Lloret‐Fillol Julio 
Published: June 2018

AbstractInvited for the cover of this issue is the group of Julio Lloret‐Fillol from ICIQ, Tarragona, Spain. The cover image shows the X‐ray crystallographic structure of a copper complex held by four hands.
Ultralow Cost Electrochemical Sensor Made of Potato Starch and Carbon Black Nanoballs to Detect Tetracycline in Waters and Milk
Authors: Delgado Karina P. , Raymundo‐Pereira Paulo A. , Campos Anderson M. , Oliveira Osvaldo N. , Janegitz Bruno C. 
Published: June 2018

AbstractDetection of traces from pharmaceutical drugs such as antibiotics in drinking water and foodstuff is essential for guaranteeing human health in some environments, and this has to be done with low cost technologies to be widely deployed in public services and industry. In this paper, we describe an ultralow cost (<US$ 0.005 per unit of sensing layer) electrochemical sensor to detect the antibiotic tetracycline, which is made of a homogeneous thin film of potato starch (PS) and carbon black (CB) deposited on glassy carbon electrodes (GCE). Detection of tetracycline was also performed in real samples consisting of tap water, river water, milk and in solutions prepared with commercial tablets of this medicine in the range between 5.0 and 120 μmol L−1, with a detection and quantification limit of 1.15 and 4.47 μmol L−1, respectively. The high sensitivity was attributed to the enhanced conductivity and larger surface area induced by incorporating the carbon black into potato starch. The CB‐PS/GCE electrodes were reproducible and stable, thus serving as a generic platform for detection of other antibiotics and hormones whose redox potentials are similar to those of tetracycline.
Predictive factors for successful cervical ripening using a double‐balloon catheter after previous cesarean delivery
Authors: Vital Mathilde , Grange Joséphine , Le Thuaut Aurélie , Dimet Jérôme , Ducarme Guillaume 
Published: June 2018

AbstractObjectiveTo identify predictors of successful cervical ripening using double‐balloon catheter (DBC) for labor induction among women with previous cesarean delivery (PCD) and unfavorable cervix at term.MethodsThe present prospective observational study was conducted among women who underwent cervical ripening with DBC at a French tertiary care hospital between January 1, 2014, and December 31, 2017. Inclusion criteria were PCD; singleton term fetus; cephalic presentation; and unfavorable cervix (Bishop score <6). Indications for DBC were gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, pre‐eclampsia, prolonged pregnancy, fetal growth restriction, or prenatal suspicion of macrosomia. The primary outcome was Bishop score of at least six after DBC removal.ResultsAmong the 105 patients included, the initial Bishop score was 2.5 ± 1.5; successful cervical ripening occurred among 74 (70.5%) women; and vaginal delivery occurred among 46 (43.8%). The mean time from DBC insertion to delivery was 19.3 ± 6.7 hours. No adverse events were observed. Predictors of successful cervical ripening were initial Bishop score of at least three (adjusted odds ratio [aOR] 12.74, 95% confidence interval [CI] 2.78–58.47); PCD during labor (aOR 4.38, 95% CI 1.10–17.45); and internal cervical os open (aOR 4.94, 95% CI 1.44–17.01).ConclusionSeveral factors were found to predict successful cervical ripening using DBC.