bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of baking soda dentifrice in controlling plaque and gingivitis: A systematic review
Authors: Valkenburg Cees , Kashmour Yasmin , Dao Angelique , (Fridus) Van der Weijden G. A. , Slot Dagmar Else 
Published: February 2019

AbstractObjectiveTo test the efficacy of a dentifrice containing baking soda (BS), compared with dentifrice without BS for controlling plaque and gingivitis.Materials and methodsMEDLINE‐PubMed and Cochrane‐CENTRAL were searched. The inclusion criteria were randomized controlled clinical trials including healthy participants aged 18 years or older. Studies were selected that compared the effect of toothbrushing with a dentifrice with and without BS on the clinical parameters of plaque and gingivitis. Data were extracted from the selected studies, and a meta‐analysis was performed.ResultsThe search retrieved 21 eligible publications. Among these papers, 43 comparisons were provided, with 23 involving a single‐use design and 20 being evaluations with a follow‐up. Negative controls were found, or positive controls for which various active ingredients had been used. The included studies showed a moderate overall potential risk of bias and considerable heterogeneity. The meta‐analysis of plaque scores from the single‐brushing experiments showed that BS dentifrice (BS‐DF) was associated with significantly better outcomes than the negative control dentifrices (DiffM −0.20; P < 0.0001; 95% CI: [−0.27; −0.12]) or the positive control dentifrices (DiffM −0.18; P < 0.0001; 95% CI: [−0.24; −0.12]). This finding was only confirmed in studies that used a follow‐up design as compared to a negative control (DiffM −0.19; P = 0.01; 95% CI: [−0.34; −0.04]). The indices of gingival bleeding also improved when the comparison was a negative control (DiffM −0.08; P = 0.02; 95% CI: [−0.16; −0.01] and (DiffM −0.13; P < 0.001; 95% CI: [−0.18; −0.08]. However, for the gingival index scores, the meta‐analysis did not reveal any significant differences.ConclusionBS‐DF showed promising results with respect to plaque removal in single‐use studies. However, the finding was partially substantiated in follow‐up studies. Studies that assessed bleeding scores indicated that a small reduction can be expected from BS, relative to a control product.
New food ingredients from broccoli by‐products: physical, chemical and technological properties
Authors: Shi Meng , Hlaing Mya Myintzu , Ying DanYang , Ye JianHui , Sanguansri Luz , Augustin Mary Ann 
Published: February 2019

SummaryBroccoli stems and leaves examined were rich in protein (23.2%, dry weight), fibre (36.5%, dry weight) and polyphenols (11.4 mg gallic acid equivalents g−1). Chlorogenic acid, neochlorogenic acid and quinic acid were the major phenolics found. Broccoli by‐products have potential to be developed as differentiated food ingredients by separation. On a dry basis, the pomace and washed pomace fractions were enriched in fibre and had higher water‐holding but lower water solubility and emulsifying capacity compared to juice and supernatant from washed pomace, which were enriched in protein. The juice and supernatant had higher polyphenol content and higher antioxidant activity, suggesting that polyphenols were the major contributors to antioxidant activity. For convenience of use, the products may be supplied as packaged powdered ingredients, but this was practical only for broccoli stems and leaves and pomaces as these powders had higher glass transition temperatures than the juice and supernatant fractions.
Valorisation of grape pomace (cv. Muscat) for development of functional cookies
Authors: Theagarajan Radhika , Malur Narayanaswamy Lavanya , Dutta Sayantani , Moses Jeyan A. , Chinnaswamy Anandharamakrishnan 
Published: February 2019

SummaryFruit juice industries and wineries generate considerable amount of grape pomace as waste from fresh grapes. However, the nutritional assets of grape pomace that include antioxidants, mainly polyphenols, should not be neglected, and be further processed in developing food supplements. In this study, grape pomace (cv. Muscat) was found to be indeed nutrient‐rich. This pomace was subsequently employed in development of grape pomace cookies, as a functional snack. The characterisation of the grape pomace cookies delineated their healthfulness in terms of antioxidant potential, and storability in terms of higher shelf life, at 6% w/w in cookie dough. The present study highlights the importance of utilising a wasted bioresource in adding functional value to a common food that otherwise is only a fat‐rich snack.
Control and emotions: Understanding the dynamics of controllee behaviours in a health care information systems project
Authors: Murungi David , Wiener Martin , Marabelli Marco 
Published: February 2019

AbstractThe control of information systems (IS) projects is important for organizations seeking to realize the value‐creating capabilities of information technology (IT). However, their achievement has proven complex and has triggered research on the unique challenges related to IS project control. The existing research focuses primarily on the contextual antecedents and performance effects of control‐mode choices but largely neglects the dynamics of control activities, and particularly the socio‐emotional aspects of such activities. We conducted longitudinal fieldwork to evaluate the dynamic interplay between control activities and emotions in the context of a large‐scale, health care IS project. Our case analysis provides empirical evidence for the link between controllers' control styles and controllees' emotions and subsequent behaviours. For instance, our analysis results point to “suppressed” effects of negative emotions on control effectiveness. We find that while controllees' negative emotional appraisals of control activities do not necessarily translate into immediate resistance behaviours, they can give rise to delayed resistance behaviours triggered by shifting control styles.
A systematic review and meta‐analysis of dental plaque control among children and adolescents with intellectual disabilities
Authors: McGrath Colman , Zhou Ni , Wong Hai Ming 
Published: February 2019

AbstractBackgroundPeople with intellectual disabilities (ID) typically have poorer oral health. Oral diseases have a microbiological origin, and thus, dental plaque control (DPC) is key to safeguard their oral health.MethodsA structured search strategy was applied to screen oral health promotion initiatives for DPC among children and adolescents with ID following PRISMA statements. Qualitative and quantitative analyses were performed.ResultsFrom 1,455 citations, 22 studies informed this review. Seven studies related to mechanical interventions and 13 to chemical interventions. Qualitative analyses found conventional toothbrushes were less effective than modified toothbrushes but quantitative analyses were conflicting. Of the nine studies that compared chlorhexidine to placebos, seven reported chlorhexidine was more effective than placebos. Meta‐analysis favoured chlorhexidine to placebos (p < 0.0001, 95% CI 0.34–0.63).ConclusionsBoth mechanical and chemical interventions are effective for DPC. It is unclear whether they are alternative means for DPC or whether they are best employed together.
Osteoporosis is inversely associated with arterial stiffness in the elderly: An investigation using the Osteoporosis Self‐assessment Tool for Asians index in an elderly Chinese cohort
Authors: Xuan Yan , Wang Weiliang , Zhang Hong , Tan Isabella , Butlin Mark , Avolio Alberto , Zuo Junli 
Published: February 2019

Although the association of arterial stiffness and osteoporosis has been reported, the relation of arterial stiffness with risk of osteoporosis and bone fracture is not established. The authors investigated the correlation between arterial stiffness (brachial‐ankle pulse wave velocity [baPWV]), including a cutoff value, and risk of osteoporosis as assessed by the Osteoporosis Self‐assessment Tool for Asia (OSTA) index in 129 elderly Chinese community‐dwelling individuals (age 83.2 ± 12.8 years, 63 females). OSTA was negatively correlated with baPWV (r = −0.326, P = 0.023) after adjusting for confounding factors such as gender, body mass index, low‐density lipoprotein, triglycerides, estimated glomerular filtration rate, absence or presence of diabetes, absence or presence of hypertension, and uric acid. baPWV was an independent factor for changes in OSTA (β = −0.001, P = 0.002). ROC curve analysis confirmed association between baPWV and OSTA index (AUC = 0.742 [CI: 0.660, 0.824]; P < 0.001) with a baPWV cutoff value of 1676 cm/s (sensitivity, 80.7%; specificity, 60%) for prediction of high OSTA index. The study showed a significant correlation between OSTA index and baPWV, suggesting a potential predictive value of baPWV in elderly patient at high risk of osteoporosis.
MicroRNA‐1258, regulated by c‐Myb, inhibits growth and epithelial‐to‐mesenchymal transition phenotype via targeting SP1 in oral squamous cell carcinoma
Authors: Zhang Hua , Jiang Sui , Guo Longbin , Li Xi 
Published: February 2019

AbstractThe biological function and underlying mechanism of miR‐1258 has seldom been investigated in cancer progression, including in oral squamous cell carcinoma (OSCC). In the current study, we revealed that the expression level of miR‐1258 was significantly down‐regulated in OSCC tissues and cell lines. Restoration of miR‐1258 decreased OSCC cell growth and invasion. The luciferase and Western blot assays revealed that SP1 protein was a downstream target of miR‐1258. Overexpression of SP1 dismissed miR‐1258’s effect on cell growth and invasion. We also revealed that c‐Myb inhibited miR‐1258 by directly binding at its promoter. In addition, miR‐1258 inhibited PI3K/AKT and ERK signalling pathway activity. Taken together, these findings demonstrated that miR‐1258 may function as a tumour‐suppressive micorRNA in OSCC and suggested that miR‐1258 may be a potential therapeutic target for OSCC patients.
Starting Up a Hospital at Home Program: Facilitators and Barriers to Implementation
Authors: Brody Abraham A. , Arbaje Alicia I. , DeCherrie Linda V. , Federman Alex D. , Leff Bruce , Siu Albert L. 
Published: February 2019

BackgroundHospital at home (HaH) is a model of care that provides acute‐level services in the home. HaH has been shown to improve quality and patient satisfaction, and reduce iatrogenesis and costs. Uptake of HaH in the United States has been limited, and little research exists on how to implement it successfully.ObjectivesThis study examined facilitators and barriers to implementation of an HaH program.DesignA HaH program that included a 30‐day transitional care bundle following the acute stay was implemented through a Centers for Medicare & Medicaid Services Innovations Award. Informants completed a priming table describing initial implementation components, their barriers, and facilitators. These were followed up with semistructured focus groups and individual interviews that were transcribed and independently coded using thematic analysis by two independent investigators.SettingLarge urban academic health system.ParticipantsClinical and administrative personnel from Mount Sinai, the Visiting Nurse Service of New York, and executive leaders at partner organizations (laboratory, pharmacy, radiology, and transportation).ResultsTo facilitate successful development and implementation of a high‐quality HaH program, a number of barriers needed to be overcome through significant teamwork and communication internally with policymakers and external partners. Areas of paramount importance include facilitating work‐arounds to regulatory barriers and health system policies; altering an electronic health record that was not designed for HaH; developing the necessary payment and billing mechanisms; and building effective and collaborative partnerships and communication with outside vendors.ConclusionDevelopment of HaH programs in the United States are feasible but require strategic planning and development of strong, tightly coordinated partnerships. J Am Geriatr Soc 67:588–595, 2019.
Peak cement‐related CO2 emissions and the changes in drivers in China
Authors: Shan Yuli , Zhou Ya , Meng Jing , Mi Zhifu , Liu Jingru , Guan Dabo 
Published: February 2019

AbstractIn order to fight against the climate change, China has set a series of emission reduction policies for super‐emitting sectors. The cement industry is the major source of process‐related emissions, and more attention should be paid to this industry. This study calculates the process‐related, direct fossil fuel–related, and indirect electricity‐related emissions from China's cement industry. The study finds that China's cement‐related emissions peaked in 2014. The emissions are, for the first time, divided into seven parts based on the cement used in different new building types. The provincial emission analysis finds that developed provinces outsourced their cement capacities to less developed regions. This study then employs index decomposition analysis to explore the drivers of changes in China's cement‐related emissions. The results show that economic growth was the primary driver of emission growth, while emission intensity and efficiency were two offsetting factors. The changes in the construction industry's structure and improvement in efficiency were the two major drivers that contributed to the decreased emissions since 2014.
Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP+
Authors: Boonying Wassamon , Joselin Alvin , Huang En , Qu Dianbo , Safarpour Farzaneh , Iyirhiaro Grace O. , Gonzalez Yasmilde Rodriguez , Callaghan Steve M. , Slack Ruth S. , Figeys Daniel , Chung Young‐Hwa , Park David S. 
Published: February 2019

AbstractLoss of function mutations in the PTEN‐induced putative kinase 1 (Pink1) gene have been linked with an autosomal recessive familial form of early onset Parkinson's disease (PD). However, the underlying mechanism(s) responsible for degeneration remains elusive. Presently, using co‐immunoprecipitation in HEK (Human embryonic kidney) 293 cells, we show that Pink1 endogenously interacts with FK506‐binding protein 51 (FKBP51 or FKBP5), FKBP5 and directly phosphorylates FKBP5 at Serine in an in vitro kinase assay. Both FKBP5 and Pink1 have been previously associated with protein kinase B (AKT) regulation. We provide evidence using primary cortical cultured neurons from Pink1‐deficient mice that Pink1 increases AKT phosphorylation at Serine 473 (Ser473) challenged by 1‐methyl‐4‐phenylpyridinium (MPP+) and that over‐expression of FKBP5 using an adeno‐associated virus delivery system negatively regulates AKT phosphorylation at Ser473 in murine‐cultured cortical neurons. Interestingly, FKBP5 over‐expression promotes death in response to MPP+ in the absence of Pink1. Conversely, shRNA‐mediated knockdown of FKBP5 in cultured cortical neurons is protective and this effect is reversed with inhibition of AKT signaling. In addition, shRNA down‐regulation of PH domain leucine‐rich repeat protein phosphatase (PHLPP) in Pink1 WT neurons increases neuronal survival, while down‐regulation of PHLPP in Pink1 KO rescues neuronal death in response to MPP+. Finally, using co‐immunoprecipitation, we show that FKBP5 interacts with the kinase AKT and phosphatase PHLPP. This interaction is increased in the absence of Pink1, both in Mouse Embryonic Fibroblasts (MEF) and in mouse brain tissue. Expression of kinase dead Pink1 (K219M) enhances FKBP5 interaction with both AKT and PHLPP. Overall, our results suggest a testable model by which Pink1 could regulate AKT through phosphorylation of FKBP5 and interaction of AKT with PHLPP. Our results suggest a potential mechanism by which PINK1‐FKBP5 pathway contributes to neuronal death in PD.Open Science BadgesThis article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found at https://cos.io/our-services/open-science-badges/.
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Localization of phosphatidylinositol 4‐phosphate 5‐kinase (PIP5K) α, β, γ in the three major salivary glands in situ of mice and their response to β‐adrenoceptor stimulation
Authors: Khrongyut Suthankamon , Rawangwong Atsara , Pidsaya Atthapon , Sakagami Hiroyuki , Kondo Hisatake , Hipkaeo Wiphawi 
Published: February 2019

AbstractPhosphatidylinositol 4‐phosphate 5‐kinase (PIP5K), which is composed of three isozymes (α, β and γ), catalyzes the production of phosphatidylinositol bisphosphate (PIP2). This phospholipid functions in membrane trafficking, as an anchor for actin cytoskeletons and as a regulator of intramembranous channels/transporters. It is also a precursor of such second messengers as diacylglycerol, inositol triphosphate and phosphatidylinositol (3,4,5)‐triphosphate. In the present study, the expression and localization of endogenous PIP5Ks were examined in the three major salivary glands of young adult mice in situ. In western blotting of normal control glands, immunoreactive bands for individual PIP5Ks were detectable, with the highest density in the parotid gland and the weakest density in the submandibular gland. In immuno‐light microscopy under non‐stimulated condition, weak immunoreactivity for PIP5Kα was confined to the apical plasmalemma in parotid, but not sublingual or submandibular, acinar cells. Immunoreactivity for PIP5Kβ was weak to moderate and confined to ductal cells but not acinar cells, whereas that for PIP5Kγ was selectively and intensely detected in myoepithelial cells but not acinar cells, and it was weak in ductal cells in the three glands. In western blot of the parotid gland stimulated by isoproterenol, a β‐adrenoceptor agonist, no changes were seen in the intensity of immunoreactive bands for any of the PIP5Ks. In contrast, in immuno‐light microscopy, the apical immunoreactivity for PIP5Kα in parotid acinar cells was transiently and distinctly increased after the stimulation. The increased immunoreactivity was ultrastructurally localized on most apical microvilli and along contiguous plasma membrane, where membranous invaginations of various shapes and small vesicles were frequently found. It was thus suggested that PIP5Kα is involved in post‐exocytotic membrane dynamics via microvillous membranes. The present finding further suggests that each of the three isoforms of PIP5K functions through its product PIP2 discretely in different cells of the glands to regulate saliva secretion.
Effects of lidocaine spray for reducing pain during endometrial aspiration biopsy: A randomized controlled trial
Authors: Piyawetchakarn Ratpaporn , Charoenkwan Kittipat 
Published: February 2019

AbstractAimTo examine the effect of lidocaine spray for reducing pain during endometrial aspiration biopsy by comparing it with placebo and no intervention.MethodsWomen undergoing endometrial aspiration biopsy from March 2017 to January 2018 were invited to participate. The participants were randomly assigned into three groups. In group 1 (lidocaine spray), eight puffs (80 mg, 10 mg/puff, 0.8 mL) of 10% lidocaine spray was applied thoroughly to the cervix, 3 min before starting the procedure. For group 2 (placebo spray), 0.8 mL of normal saline spray was applied to the cervix, 3 min before starting the procedure. For group 3 (no intervention), no anesthesia was given. The patients rated their pain according to a 10‐cm visual analog scale at different points including baseline, immediately after the procedure (biopsy pain), and 10 min after the procedure. The 10‐cm visual analog scale on satisfaction was also rated before hospital discharge. Comparison of continuous variables was made by using Kruskal–Wallis test. Chi squared test was used for comparison of categorical variables.ResultsTwo hundred and forty patients (80 in each group) participated. The mean baseline, biopsy and postprocedural pain scores were not significantly different among the study groups. Similarly, the mean difference between the biopsy and the baseline pain scores were comparable among the groups. In addition, there was no difference on the satisfaction scores among the groups.ConclusionLidocaine spray applied to the cervix is not effective for reducing pain associated with pipelle endometrial aspiration biopsy.
Multiple primary cancers associated with endometrial and ovarian cancers: An analysis based upon the Japan Autopsy Annual Database from 2002 to 2010
Authors: Miki Yasuhiro , Sugawara Yumi , Shibahara Yukiko , Tsuji Ichiro , Sasano Hironobu , Ito Kiyoshi 
Published: February 2019

AbstractAimA thorough analysis of multiple primary cancers (MPC) could provide important information as to the pathogenesis of human malignancies. Analysis of MPC using clinical databases has been performed, but little has been done using autopsy cases. Therefore, in this study, we first retrospectively analyzed MPC associated with endometrial and ovarian cancers using the Japan Autopsy Annual Database.MethodsThe Japan Autopsy Annual Database from 2002 to 2010 was established by the Japanese Society of Pathology, Tokyo, Japan. Among the 164 211 autopsy cases registered, 9142 were cases of primary cancers.ResultsThe patients with endometrial cancer‐associated MPC did have a lower risk of harboring colorectal cancer (odds ratio [OR], 0.63; 95% confidence interval [CI], 0.45–0.89) but had a higher risk of ovarian cancer (OR, 3.15; 95% CI, 2.11–4.71). Those with ovarian cancer‐associated MPC had a lower risk of harboring gallbladder cancer including bile ductal cancer (OR, 0.47; 95% CI, 0.27–0.80) but a higher risk of harboring breast (OR, 1.69; 95% CI, 1.20–2.38) and endometrial cancers (OR, 3.48; 95% CI, 2.33–5.20).ConclusionBoth endogenous and exogenous factors are associated with the incidence of MPC. Results of our present study based on Japanese Autopsy Base first demonstrated that female hormones had a strong influence on the incidence of MPC. This study also demonstrated that the analysis of MPC using an autopsy database could have advantages over clinical database analysis.
Educators' Perspectives of Collaboration With Pediatricians to Support Low‐Income Children
Authors: Lemkin Allison , Walls Morgan , Kistin Caroline J. , Bair‐Merritt Megan 
Published: February 2019

ABSTRACTBACKGROUNDEducational and healthcare systems operate in silos. Few studies explore educators' perspectives of collaboration with pediatricians or cross‐system solutions for school‐identified concerns. We sought to investigate educators' viewpoints of collaboration with pediatricians.METHODSWe conducted semistructured, qualitative interviews with full‐time teachers, vice‐principals, and principals, who worked with low‐income first‐ or second‐grade students. Interviews explored which students were concerning to educators, educators' experiences with collaboration, and barriers and facilitators of collaboration. Interview transcripts were analyzed with modified grounded theory.RESULTSWe interviewed 12 teachers and 3 principals/vice‐principals. Students' socioemotional problems were a foremost concern. Effective collaboration with pediatricians was not typical. Participants described not knowing they could communicate with pediatricians or that collaboration was often limited or unidirectional. Respecting boundaries of parental privacy and maintaining parental trust emerged as potential barriers. Some participants described negative experiences with pediatricians and reflected on societal perceptions of doctors and teachers, which could affect the development of relationships. Participants recognized potential benefits to collaboration, including gaining a holistic understanding of a child's health and home life.CONCLUSIONSEducators perceived collaboration with pediatricians as inadequate. More developed and tested programs that foster collaboration between schools and pediatricians are needed to support low‐income youth.