bluuebunny/crossref_metadata_2025_split huggingface dataset:
WCC 2017-A-112: CT Angiographic Assessment of Coronary Artery Bypass Graft
Authors: Mashirkar Abhishek , Sonawane Bhwana 
Published: June 2018

AbstractIntroduction: CT Angiography (CTA) is a noninvasive imaging modality to evaluate the vascular system. In coronary artery bypass graft patients, this study is helpful to evaluate the status of graft.
Das unsichtbare Symptom
Authors: Klingebiel Alessa 
Published: June 2018

ZusammenfassungStändige oder plötzlich auftretende totale Erschöpfung – der Akku ist leer, es fehlt die Kraft die alltäglichsten Aufgaben zu bewältigen. Fatigue ist
eines der am häufigsten unterschätzten Begleitsymptome vieler neurologischer oder onkologischer Erkrankungen und deren Therapie. Es schränkt den Alltag und die
Lebensqualität der Betroffenen und ihrer Angehörigen stark ein.
Muskelschmerz
Authors: Lütgendorf F. , Triantafyllias K. 
Published: June 2018

ZusammenfassungMyalgien zählen zu den häufigsten Gründen für eine Vorstellung beim Rheumatologen oder Orthopäden. Die Ursachen einer Myalgie sind vielfältig und können ein Trauma, übermäßige körperliche Anstrengung und virale Infekte ebenso umfassen wie eine Genese auf der Basis ernsthafter, nicht entzündlicher Myopathien oder Myositiden. In dieser Übersichtsarbeit richten wir einen Fokus sowohl auf die Diagnostik von häufig auftretenden und damit auch fachübergreifend gut bekannten Krankheitsbildern als auch auf solche, die seltener im rheumatologischen Alltag vorkommen. Vom recht geläufigen chronischen Schmerzsyndrom Fibromyalgie bis hin zum seltenen Krankheitsbild des Antisynthetase-Syndroms werden hier neben den klinischen Bildern neue Daten zu laborchemischen, histologischen und radiologischen Auffälligkeiten der wichtigsten rheumatologischen Erkrankungen diskutiert, welche charakteristisch mit Myalgien einhergehen. Im Rahmen dieser Arbeit wird eines deutlich: Die Komplexität dieser Krankheitsbilder und der Umfang aktueller Forschungsergebnisse fordern die kontinuierliche Schulung der behandelnden Ärzte und eine enge interdisziplinäre Zusammenarbeit der unterschiedlichen Fachdisziplinen.
Money Matters: The Role of Yields and Profits in Agricultural Technology Adoption
Authors: Michler Jeffrey D. , Tjernström Emilia , Verkaart Simone , Mausch Kai 
Published: June 2018

AbstractDespite the growing attention to technology adoption in the economics literature, knowledge gaps remain regarding why some valuable technologies are rapidly adopted, while others are not. This paper contributes to our understanding of agricultural technology adoption by showing that a focus on yield gains may, in some contexts, be misguided. We study a technology in Ethiopia that has no impact on yields, but that has nonetheless been widely adopted. Using three waves of panel data, we estimate a correlated random coefficient model and calculate the returns to improved chickpea in terms of yields, costs, and profits. We find that farmers’ comparative advantage does not play a significant role in their adoption decisions and hypothesize that this is due to the overall high economic returns to adoption, despite the limited yield impacts of the technology. Our results suggest economic measures of returns may be more relevant than increases in yields in explaining technology adoption decisions.
Chondrosarcoma of the Osseous Spine Treated by Surgery With or Without Radiotherapy
Authors: Chen Dong , Chen Chun-Hui , Zhang Li-Lian , Lin Zhong-Ke , Zheng Jing-Wei , Phan Kevin , Mobbs Ralph J. , Lin Yan , Ni Wen-Fei , Wang Xiang-Yang , Li Yan Michael , Wu Ai-Min 
Published: June 2018

Study Design:
This was a longitudinal cohort study.

Objective:
The main objective of this study was to investigate the outcomes of surgery with or without radiotherapy during treatment of patients with chondrosarcoma of the osseous spine.

Summary of Background Data:
Chondrosarcoma is a primary spinal malignant tumor; chemotherapy and radiotherapy (RT) are generally unsuccessful, and thus, the main treatment of choice is complete en bloc resection. However, even with complete resection, these patients still have a significant rate of recurrence, morbidity, and mortality. Although there have been reports that the addition of RT to surgery may lead to increased survival and better cancer control, the evidence of the efficacy of RT remains controversial.

Materials and Methods:
Patients diagnosed with chondrosarcoma who are then treated by surgery alone or surgery+RT were identified and extracted from the SEER (Surveillance, Epidemiology, and End Results) database (1973-2013). Propensity score matched (PSM) analysis was performed to balance patient characteristics between surgery alone and surgery+RT groups. Patients with a different grade and stage were stratified and analyzed.

Results:
A total of 778 patients with chondrosarcoma of the osseous spine treated by surgery alone or surgery+RT were extracted from the SEER database. Before PSM, the unadjusted Kaplan-Meier curve and bivariable Cox proportional hazard regression models showed that the surgery alone group had higher chondrosarcoma cancer–specific survival and overall survival than the surgery+RT group (both P<0.001), while the difference was attenuated after PSM. Stratified analysis found that RT was worse for low-grade chondrosarcoma patients and had a better trend for high-grade chondrosarcoma patients.

Conclusions:
The results of our present study suggest that low-grade chondrosarcoma of the osseous spine is resistant to RT, while high-grade chondrosarcoma patients had a better trend with RT.

Level of Evidence:
Level III.
Gastroschisis and Cumulative Stressor Exposures
Authors: Werler Martha M. , Guéry Esther , Waller Dorothy K. , Parker Samantha E. 
Published: June 2018

Background:
Gastroschisis, a congenital defect of the abdominal wall, occurs disproportionately more in offspring of young mothers and has been increasing in prevalence over the past decades. A wide range of exposures have been reported in association with an increased gastroschisis risk, independent of mother’s age; many have also been correlated with stress responses.

Methods:
We explored cumulative exposures to such stressor exposures among 1,261 mothers of gastroschisis cases and 10,682 mothers of controls in the National Birth Defects Prevention Study (1997–2011). We considered 16 exposures as stressors in the first trimester: fever, genitourinary infection, anti-herpetic medication use, injury, bronchodilator use, cigarette smoking, alcohol intake, illicit drug use, prescription opioid use, oral contraceptive use, interpregnancy interval < 12 months, residential move, aspirin use, ibuprofen use, venlafaxine use, and paroxetine use.

Results:
Mothers of cases reported more stressor exposures than controls. For 1, 2, 3, and ≥ 4 stressor exposures compared with none, the age-adjusted odds ratios (95% confidence interval) were 1.3 (1.1, 1.6), 1.7 (1.4, 2.1), 2.5 (2.0, 3.1), and 3.6 (2.9, 4.4), respectively. When we weighted cumulative stress scores according to the magnitude of stressor-specific odds ratios, similar associations were observed. Cumulative stressor exposure did not account for the strong inverse association between age and gastroschisis risk.

Conclusions:
These findings show that gastroschisis risk appears to increase with accumulation of widely different types of exposures, consistent with the hypothesis that stress-induced inflammation might play an etiologic role.
Return-to-Learn Accommodations and Concussion Perceptions Among Indiana High School Principals
Authors: Janson Isaac A. , Nittoli Vincent , White Derek , Tekulve Kristyn J. 
Published: June 2018

Objective:
Care after concussion is important for all patients, although especially critical in children and adolescents because of continued rapid brain growth and maturation. Postconcussion symptoms often lead to impaired school performance. Conflicting data regarding best return-to-learn practices make it difficult for school administrators to develop policies to best accommodate concussed students. We sought to assess high school principals' knowledge of concussion, the personnel responsible for implementing accommodations, and the overall willingness to enact recommended academic accommodations.

Methods:
In our cross-sectional study, we surveyed 410 Indiana high school principals (157 responded). Assistant principals were excluded.

Results:
One-third of the respondents received academic accommodations training for concussed students and more than 80% were somewhat or very comfortable with academic management. Greater than 90% were willing to provide accommodations as long as necessary. However, nearly 40% of responding principals were unlikely or unwilling to implement accommodations for standardized testing. National and state data suggest the median Indiana high school should expect 30 and more concussions per year; more than 90% of principals estimated that fewer than 30 concussions occurred each year at their school.

Conclusions:
The underestimation of concussion frequency highlights an opportunity for further education of high school principals to ensure all concussed students receive appropriate return-to-learn accommodations.
Relationship Between Hispanic Nativity, Residential Environment, and Productive Activity Among Individuals With Traumatic Brain Injury: A TBI Model Systems Study
Authors: Lequerica Anthony H. , Botticello Amanda , O'Neill John , Lengenfelder Jean , Krch Denise , Chiaravalloti Nancy D. , Sander Angelle M. , Bushnik Tamara , Ketchum Jessica M. , Hammond Flora M. , Dams-O'Connor Kristen , Felix Elizabeth , Johnson-Greene Doug 
Published: June 2018

Objective:
To examine the influence of nativity and residential characteristics on productive activity among Hispanics at 1 year after traumatic brain injury (TBI).

Setting:
Acute rehabilitation facilities and community follow-up.

Participants:
A total of 706 Hispanic individuals in the TBI Model Systems National Database.

Design:
Secondary data analysis from a multicenter longitudinal cohort study.

Main Measures:
Nativity (foreign born or US native), productive activity derived from interview questions regarding employment status, and other demographic information. Census data were extracted by zip code to represent residential characteristics of aggregate household income and proportion of foreign language speakers (FLS).

Results:
Among foreign-born individuals with TBI, those living in an area with a higher proportion of FLS were 2.8 times more likely to be productive than those living in areas with a lower proportion of FLS. Among individuals living in an area with a lower proportion of FLS, US-born Hispanics were 2.7 times more likely to be productive compared with Hispanic immigrants.

Conclusion:
The relationship between nativity and productive activity at 1 year post-TBI was moderated by the residential proportion of FLS. Findings underscore the importance of considering environmental factors when designing vocational rehabilitation interventions for Hispanics after TBI.
Predictors of Employment Status in Male and Female Post-9/11 Veterans Evaluated for Traumatic Brain Injury
Authors: Amara Jomana H. , Stolzmann Kelly L. , Iverson Katherine M. , Pogoda Terri K. 
Published: June 2018

Objectives:
The goal of this study was to investigate predictors of employment status in male and female post-9/11 Veterans evaluated for traumatic brain injury (TBI) in the Veterans Health Administration. Prior research suggests there are gender differences in psychosocial characteristics among this cohort.

Methods:
This was a cross-sectional analysis of post-9/11 Veterans who completed a TBI evaluation between July 2009 and September 2013.

Results:
Women had lower prevalence of deployment-related TBI (65.5%) compared with men (75.3%), but the percentages of those unemployed across the TBI diagnostic categories were similar for men (38%) and women (39%). Adjusted log-binomial regression found that unemployment was significantly associated with age, education, marital status, moderate/severe TBI, suspected posttraumatic stress disorder, depression, and drug abuse/dependence, and neurobehavioral symptom severity for men, whereas for women only more severe affective and cognitive symptoms were associated with unemployment.

Conclusions:
Although the unemployment rate was similar across gender, there was a clearer pattern of demographic and health factors, including TBI severity, that was significantly associated with employment status in men. There may be other factors contributing to the female Veteran unemployment rate, underscoring the need to investigate unique contributors to unemployment, as well as how treatment and employment services can be expanded and tailored for post-9/11 Veterans.
INADVERTENT INTRAOCULAR SURGERY IN CHILDREN WITH UNSUSPECTED RETINOBLASTOMA
Authors: Kaliki Swathi , Taneja Shikha , Palkonda Vijay A. R. 
Published: June 2018

Purpose:
To study the clinical presentation and treatment outcome of patients who underwent inadvertent intraocular surgery before the diagnosis of retinoblastoma.

Design:
Retrospective study of 14 patients who had undergone an inadvertent intraocular surgery before the diagnosis of retinoblastoma.

Results:
The mean age at presentation to the ocular oncology clinic was 69 months. The most common initial misdiagnosis was endophthalmitis (n = 4). The most common inadvertent intraocular surgeries were pars plana vitrectomy (n = 6) with/without lensectomy and evisceration with/without previous pars plana vitrectomy (n = 5). The mean interval between intraocular procedure and initiation of treatment for retinoblastoma was 7 months. At presentation in the oncology clinic, the tumor was intraocular (n = 3), with extrascleral tumor extension (n = 11), and/or optic nerve tumor extension (n = 5). All patients were started on multimodal treatment including 12 cycles of high-dose systemic chemotherapy, enucleation or orbital exenteration, and orbital external beam radiotherapy. Over a mean follow-up period of 27 months, 8 (57%) patients died because of progressive disease despite initiation of treatment.

Conclusion:
Misdiagnosis and inadvertent surgical intervention in cases of retinoblastoma in combination with delayed initiation of appropriate treatment is associated with poor prognosis. High index of suspicion for retinoblastoma is needed to avoid misdiagnosis and mismanagement.
Vision-Related Quality of Life in Iranian Patients With Keratoconus: National Eye Institute Vision Function Questionnaire-25
Authors: Mahdaviazad Hamideh , Bamdad Shahram , Roustaei Narges , Mohaghegh Sahar 
Published: June 2018

Background:
Use of patient-reported outcomes to evaluate the impact of ocular conditions on quality of life (QoL) is rising. Hence, the aims of this study were to determine the impact of keratoconus on QoL, and assess the National Eye Institute of the United States Vision Function Questionnaire (NEI-VFQ) performance in an Iranian population.

Methods:
From November 2016 to June 2017, patients with keratoconus definitive diagnosis for more than one year who were being routinely followed at a cornea clinic were recruited. The NEI-VFQ-25 was administered during a face-to-face interview. Ocular examinations comprised best-corrected visual acuity (BCVA) was logged monocularly and binocularly, anterior segment biomicroscopy, refraction, and corneal topography. Keratoconus severity was graded based on steep keratometric (K) reading values. A group of 30 age- and sex-matched subjects with other ocular diseases (except keratoconus) were selected randomly from the cornea clinic. P<0.05 was considered as significant.

Results:
The mean age of participants was 28.7±7.6 years. The lowest NEI-VFQ subscale scores were related to ocular pain, general vision, mental health, and role difficulty. Almost all NEI-VFQ scores in patients were statistically significant less than mean score of the control group. Composite and all subscales NEI-VFQ scores were lower significantly among patients with higher disease duration (≥5 years). Among clinical data, patients with BCVA ≥0.5 in the better eye had significantly lower NEI-VFQ composite score. Severe keratoconus patients (steep K reading ≥52) had lower NEI-VFQ scores in mental health and dependency subscales (P<0.05). The overall and subscales Cronbach α was above 0.7.

Conclusion:
Iranian patients with keratoconus had physical, emotional, and social impairment in QoL. The NEI-VFQ-25 might be applicable in further studies.
Conjunctival Squamous Neoplasia: Staging and Initial Treatment
Authors: Bellerive Claudine , Berry Jesse L. , Polski Ashley , Singh Arun D. 
Published: June 2018

Purpose:
To evaluate the clinical relevance of the American Joint Committee on Cancer (AJCC) classification in the initial management of squamous neoplasia of the conjunctiva.

Methods:
This retrospective study enrolled 95 histopathologically proven cases of treatment-naive conjunctival squamous neoplasia. Tumors were classified into 4 histological groups: conjunctival intraepithelial neoplasia (CIN) with mild dysplasia (grade 1/3), moderate dysplasia (grade 2/3), severe dysplasia (grade 3/3 or carcinoma in situ), and invasive squamous cell carcinoma (SCC). Clinical findings such as tumor location, largest basal diameter, growth pattern, and adjacent structures involved were recorded.

Results:
CIN was observed in 74 cases (78%), and SCC was noted in 21 cases (22%). Based on the AJCC classification, all the 74 cases of CIN were classified as Tis (tumor in situ). Among the invasive SCC, there were 3 T1 tumors, 2 T2 tumors, and 16 T3 tumors. Complete excision with or without adjuvant therapy was selected as initial treatment in 80% of cases (76/95). Two cases of SCC with scleral invasion were treated using brachytherapy.

Conclusions:
The AJCC stage does not correlate with the initial treatment of CIN. The AJCC T3 category should be reviewed to differentiate diffuse SCCs with broad surface extension from tumors with deep scleral invasion.
Sensory sensitivity and symptom severity represent unique dimensions of chronic pain: a MAPP Research Network study
Authors: Schrepf Andrew , Williams David A. , Gallop Robert , Naliboff Bruce D. , Basu Neil , Kaplan Chelsea , Harper Daniel E. , Landis J. Richard , Clemens J. Quentin , Strachan Eric , Griffith James W. , Afari Niloofar , Hassett Afton , Pontari Michel A. , Clauw Daniel J. , Harte Steven E. ,   for the MAPP Research Network
Published: June 2018

Abstract
Chronic overlapping pain conditions (COPCs) are characterized by aberrant central nervous system processing of pain. This “centralized pain” phenotype has been described using a large and diverse set of symptom domains, including the spatial distribution of pain, pain intensity, fatigue, mood imbalances, cognitive dysfunction, altered somatic sensations, and hypersensitivity to external stimuli. Here, we used 3 cohorts, including patients with urologic chronic pelvic pain syndrome, a mixed pain cohort with other COPCs, and healthy individuals (total n = 1039) from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network to explore the factor structure of symptoms of centralized pain. Using exploratory and confirmatory factor analysis, we identified 2 general factors in all 3 cohorts, one characterized by a broad increased sensitivity to internal somatic sensations,environmental stimuli, and diffuse pain, termed Generalized Sensory Sensitivity, and one characterized by constitutional symptoms—Sleep, Pain, Affect, Cognition, Energy (SPACE). Longitudinal analyses in the urologic chronic pelvic pain syndrome cohort found the same 2-factor structure at month 6 and 1 year, suggesting that the 2-factor structure is reproducible over time. In secondary analyses, we found that Generalized Sensory Sensitivity particularly is associated with the presence of comorbid COPCs, whereas SPACE shows modest associations with measures of disability and urinary symptoms. These factors may represent an important and distinct continuum of symptoms that are indicative of the centralized pain phenotype at high levels. Future research of COPCs should accommodate the measurement of each factor.
Prenatal Bisphenol A Exposure in Mice Induces Multi-tissue Multi-omics Disruptions Linking to Cardiometabolic Disorders
Authors: Shu Le , Meng Qingying , Tsai Brandon , Diamante Graciel , Chen Yen-Wei , Mikhail Andrew , Luk Helen , Ritz Beate , Allard Patrick , Yang Xia 
Published: June 2018

AbstractThe health impacts of endocrine disrupting chemicals (EDCs) remain debated and their tissue and molecular targets are poorly understood. Here, we leveraged systems biology approaches to assess the target tissues, molecular pathways, and gene regulatory networks associated with prenatal exposure to the model EDC Bisphenol A (BPA). Prenatal BPA exposure led to scores of transcriptomic and methylomic alterations in the adipose, hypothalamus, and liver tissues in mouse offspring, with cross-tissue perturbations in lipid metabolism as well as tissue-specific alterations in histone subunits, glucose metabolism and extracellular matrix. Network modeling prioritized main molecular targets of BPA, includingPparg, Hnf4a, Esr1, Srebf1, andFasn. Lastly, integrative analyses identified the association of BPA molecular signatures with cardiometabolic phenotypes in mouse and human. Our multi-tissue, multi-omics investigation provides strong evidence that BPA perturbs diverse molecular networks in central and peripheral tissues, and offers insights into the molecular targets that link BPA to human cardiometabolic disorders.
Pericarp Pigmentation Correlates with Hormones and Intensifies with Continuation of Bud Sport Generations from ‘Red Delicious’
Authors: Li Wen-Fang , Mao Juan , Yang Shi-Jin , Guo Zhi-Gang , Ma Zong-Huan , Dawuda Mohammed Mujitaba , Zuo Cun-Wu , Chu Ming-Yu , Chen Bai-Hong 
Published: June 2018

ABSTRACTBud sport mutants of apple (Malus domesticaBorkh.) trees with a highly blushed colouring pattern are mainly caused by the accumulation of anthocyanins in the pericarp. Hormones are important factors modulating anthocyanin accumulation. However, a good understanding of the interplay between hormones and anthocyanin synthesis in apples, especially in mutants at the molecular level, remains elusive. Here, physiological and comparative transcriptome approaches were used to reveal the molecular basis of pericarp pigmentation in ‘Red Delicious’ and its mutants, including ‘Starking Red’, ‘Starkrimson’, ‘Campbell Redchief’ and ‘Vallee spur’, which were designated G0 to G4, respectively. Pericarp pigmentation gradually proliferated from G0 to G4. The anthocyanin content was higher in the mutants than in ‘Red Delicious’. The activation of early phenylpropanoid biosynthesis genes, includingASP3,PAL,4CL,PER,CHS,CYP98AandF3’H, was responsible for anthocyanin accumulation in mutants. In addition, IAA and ABA had a positive regulatory effect on the synthesis of anthocyanins, while GA had the reverse effect. The down-regulation ofAACT1,HMGS,HMGR,MVK,MVD2,IDI1andFPPS2involved in terpenoid biosynthesis influences anthocyanin accumulation by positively regulating transcripts ofAUX1andSAURthat contribute to the synthesis of IAA,GID2to GA,PP2CandSnRK2to ABA. Furthermore, MYB and bHLH members, which are highly correlated (r=0.882–0.980) with anthocyanin content, modulated anthocyanin accumulation by regulating the transcription of structural genes, includingCHSandF3’H, involved in the flavonoid biosynthesis pathway.