bluuebunny/crossref_metadata_2025_split huggingface dataset:
Architecture and Assembly of Periplasmic Flagellum
Authors: Chang Yunjie , Liu Jun 
Published: August 2019

ABSTRACT

Periplasmic flagella are complex nanomachines responsible for distinctive morphology and motility of spirochetes. Although bacterial flagella have been extensively studied for several decades in the model systems
Escherichia coli
and
Salmonella enterica
, our understanding of periplasmic flagella in many disease-causing spirochetes remains incomplete. Recent advances, including molecular genetics, biochemistry, structural biology, and cryo-electron tomography, have greatly increased our understanding of structure and function of periplasmic flagella. In this chapter, we summarize some of the recent findings that provide new insights into the structure, assembly, and function of periplasmic flagella.
On plate tectonics and ocean temperatures
Authors: Vérard Christian , Veizer Ján 
Published: August 2019

Abstract
Plate tectonics, the principal vehicle for dissipation of planetary energy, is believed to buffer the δ18O of seawater at its near-modern value of 0‰ SMOW (Standard Mean Ocean Water) because the hot and cold cells of hydrothermal circulation at oceanic ridges cancel each other. The persistence of plate tectonics over eons apparently favors attribution of the well-documented oxygen isotope secular trends for carbonates (cherts, phosphates) to progressively warmer oceans, from 40–70 °C in the early Paleozoic to 60–100 °C in the Archean. We argue that these oceanic hydrothermal systems are dominated by low-temperature (<350 °C) cells that deplete the percolating water in 18O. Seawater δ18O is therefore a proxy for, rather than being buffered by, the intensity of plate tectonics. Detrending the Phanerozoic carbonate δ18Oc secular trend for its “tectonic” component yields a stationary time series that, interpreted as a proxy for Phanerozoic climate, indicates low-latitude shallow ocean temperatures oscillating between 10 and 30 °C around a baseline of 17 °C, attributes comparable to modern temperature values.
Fifteen-minute consultation: Managing a child with a new-onset squint
Authors: Hopkins Abigail , Simmons Ian 
Published: August 2019

ObjectiveTo provide a systematic approach to the child with a new squint.MethodReview of the current available literature.ConclusionSquint is a common presentation in the paediatric population. Although the parents’ primary concern may be cosmetic, a new squint in childhood may be the first sign of a serious or life-threatening ocular or neurological pathology. Thorough assessment and timely referral are essential.
Determining a reliably visible and inexpensive surface fiducial marker for use in MRI: a research study in a busy Australian Radiology Department
Authors: Izatt Maree T , Lees Deborah , Mills Susan , Grant Caroline A , Little J Paige 
Published: August 2019

ObjectivesSingle-use commercial surface fiducial markers are used in clinical imaging for a variety of applications. The current study sought to find a new, reliably visible, easily sourced and inexpensive fiducial marker alternative for use with MRI.DesignFive commonly requested MRI sequences were determined (three-dimensional (3D) T1-weighted, T1 coronal, 3D T2-weighted, T2 fat suppressed, proton density), to examine the visibility of 18 items (including a commercial fiducial marker).SettingClinical 3T MRI scanner in an Australian Tertiary Hospital and an Australian University Biomedical Engineering research group.Interventions18 marker alternatives were scanned using five common MRI sequences. Images were reformatted to obtain both an image through the mid-height of each marker and a maximum intensity z-projection image over the volume of the marker. Variations in marker intensity were profiled across each visible marker and a visibility rating defined.Main outcome measuresOutcome measures were based on quantitative assessment of a clear intensity contrast ratio between the marker and the adjacent tissue and a qualitative assessment of visibility via a 3-point scale.ResultsThe fish oil capsule, vitamin D capsule, paint ball pellet, soy sauce sushi tube and commercial markers were typically visible to a high quality on all the imaging sequences and demonstrated a clear differential in intensity contrast against the adjacent tissue. Other common items, such as plasticine ‘play doh’ and a soft ‘Jelly baby’ sweet, were surprise candidates, demonstrating high-quality visibility and intensity contrast for the 3D T1-weighted sequence.ConclusionsDepending on the basis for referral and MRI sequence chosen, four alternative fiducial markers were determined to be inexpensive, easily sourced and consistently visible. Of these, the vitamin D capsule provided an excellent balance between availability, size, cost, usability and quality of the visualised marker for all the commonly used MRI sequences analysed.
Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis
Authors: Fernandes Ricardo M , Wingert Aireen , Vandermeer Ben , Featherstone Robin , Ali Samina , Plint Amy C , Stang Antonia S , Rowe Brian H , Johnson David W , Allain Dominic , Klassen Terry P , Hartling Lisa 
Published: August 2019

ObjectiveAdverse events (AEs) associated with short-term corticosteroid use for respiratory conditions in young children.DesignSystematic review of primary studies.Data sourcesMedline, Cochrane CENTRAL, Embase and regulatory agencies were searched September 2014; search was updated in 2017.Eligibility criteriaChildren <6 years with acute respiratory condition, given inhaled (high-dose) or systemic corticosteroids up to 14 days.Data extraction and synthesisOne reviewer extracted with another reviewer verifying data. Study selection and methodological quality (McHarm scale) involved duplicate independent reviews. We extracted AEs reported by study authors and used a categorisation model by organ systems. Meta-analyses used Peto ORs (pORs) and DerSimonian Laird inverse variance method utilising Mantel-Haenszel Q statistic, with 95% CI. Subgroup analyses were conducted for respiratory condition and dose.ResultsEighty-five studies (11 505 children) were included; 68 were randomised trials. Methodological quality was poor overall due to lack of assessment and inadequate reporting of AEs. Meta-analysis (six studies; n=1373) found fewer cases of vomiting comparing oral dexamethasone with prednisone (pOR 0.29, 95% CI 0.17 to 0.48; I2=0%). The mean difference in change-from-baseline height after one year between inhaled corticosteroid and placebo was 0.10 cm (two studies, n=268; 95% CI −0.47 to 0.67). Results from five studies with heterogeneous interventions, comparators and measurements were not pooled; one study found a smaller mean change in height z-score with recurrent high-dose inhaled fluticasone over one year. No significant differences were found comparing systemic or inhaled corticosteroid with placebo, or between corticosteroids, for other AEs; CIs around estimates were often wide, due to small samples and few events.ConclusionsEvidence suggests that short-term high-dose inhaled or systemic corticosteroids use is not associated with an increase in AEs across organ systems. Uncertainties remain, particularly for recurrent use and growth outcomes, due to low study quality, poor reporting and imprecision.
Implementation and spread of a simple and effective way to improve the accuracy of medicines reconciliation on discharge: a hospital-based quality improvement project and success story
Authors: Botros Shady , Dunn John 
Published: August 2019

BackgroundChanges are often made to medications at times of transitions in care. Inadequate reconciliation during admission, transfer and discharge causes medication errors and increases risks of patient harm. Despite well-established multidisciplinary medicines reconciliation (MR) processes at hospital admission, our MR process at discharge; however, was poor. The main errors included failure to recommence withheld medicines and lack of documentation explaining changes made to medications on discharge. Our objective was to develop an intervention that supports prescribers to follow a simple standardised MR process at discharge to reduce these errors.MethodsWorking closely as a multidisciplinary team, we used improvement methodologies to design and test a process that reliably directs prescribers in surgery to use the inpatient prescribing chart as well as the MR on admission form as sources to create accurate discharge prescriptions. The project was segmented into testing, implementation, spread and sustainability.ResultsThe tested intervention helped the accuracy of discharge prescriptions steadily and quickly improve from 45% to 96% in the pilot ward. Following the successful implementation and sustainability in two separate pilot wards, the intervention was spread to the remaining eight wards producing a similar improvement.ConclusionsTo improve patient safety, it is crucial to ensure that information about medicines is effectively communicated when care is transferred between teams. Although this can be challenging, we’ve shown that it can be done effectively and reliably if this responsibility is equally shared by healthcare professionals from all disciplines while being supported by safe systems that make it easy to do the right thing. Successfully implementing a standardised multidisciplinary MR process at discharge can also reduce the reliance on pharmacists therefore freeing them to undertake other clinical roles.
Risk-adjusted survival in liver transplant patients assessed and managed by a non-transplanting centre: South West Liver Unit experience
Authors: Norton Benjamin Charles , Srivastava Ankur , Ramos Katie , Vine Louisa , Taylor Rhiannon , Aluvihare Varuna , Heaton Nigel , Cramp Matthew E 
Published: August 2019

BackgroundLiver transplant services remain a scarce resource not reflective of geography or burden of liver disease within the UK. To address geographical concerns in the South West (SW), a devolved network model of care for liver transplantation was established in 2004 between the SW Liver Unit (SWLU) at Derriford Hospital, Plymouth and King’s College Hospital, London. The SWLU has evolved to deliver both pre-transplant and post-transplant care for patients across the SW Peninsula. We determined whether risk-adjusted survival in patients assessed and managed at the SWLU compared with existing UK transplant centres.DesignRetrospective analysis of records at National Health Service Blood and Transplant (NHSBT) for patients ≥18 years listed or undergoing first liver only deceased donor transplantation from 1 January 2006 to 31 December 2017. Data collected and used were in accordance with standard NHSBT outcome measures.ResultsWe identified 8492 patients registered for first liver only transplant and 6140 patients who subsequently underwent transplantation. Of these, 215 patients listed and 172 patients transplanted were registered at the SWLU. The 1-year, 5-year and 10-year risk-adjusted post-listing survival for patients registered at the SWLU were 86%, 75% and 67%, respectively, with 1-year and 5-year risk-adjusted post-transplant survival 94.9% and 84.4%, respectively.ConclusionsRisk-adjusted post-listing 1-year, 5-year and 10-year survival outcomes and risk-adjusted 1-year and 5-year post-transplant survival outcomes at the SWLU are good and comparable with the seven UK transplant centres. These outcomes provide assurance that care delivered by our regional programme is equivalent to well-established liver transplant programmes.
Artificial Detection of Lower-Frequency Periodicity in Climatic Studies by Wavelet Analysis Demonstrated on Synthetic Time Series
Authors: Hochman Assaf , Saaroni Hadas , Abramovich Felix , Alpert Pinhas 
Published: August 2019

AbstractThe continuous wavelet transform (CWT) is a frequently used tool to study periodicity in climate and other time series. Periodicity plays a significant role in climate reconstruction and prediction. In numerous studies, the use of CWT revealed dominant periodicity (DP) in climatic time series. Several studies suggested that these “natural oscillations” would even reverse global warming. It is shown here that the results of wavelet analysis for detecting DPs can be misinterpreted in the presence of local singularities that are manifested in lower frequencies. This may lead to false DP detection. CWT analysis of synthetic and real-data climatic time series, with local singularities, indicates a low-frequency DP even if there is no true periodicity in the time series. Therefore, it is argued that this is an inherent general property of CWT. Hence, applying CWT to climatic time series should be reevaluated, and more careful analysis of the entire wavelet power spectrum is required, with a focus on high frequencies as well. A conelike shape in the wavelet power spectrum most likely indicates the presence of a local singularity in the time series rather than a DP, even if the local singularity has an observational or a physical basis. It is shown that analyzing the derivatives of the time series may be helpful in interpreting the wavelet power spectrum. Nevertheless, these tests are only a partial remedy that does not completely neutralize the effects caused by the presence of local singularities.
Design and baseline characteristics of the Biomarkers Of Risk In Colorectal Cancer (BORICC) Follow-Up study: A 12+ years follow-up
Authors: Malcomson FC , Breininger SP , ElGendy K , Joel A , Ranathunga RMTK , Hill TR , Bradburn D Michael , Turnbull DM , Greaves LC , Mathers JC 
Published: August 2019

Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Age is the strongest non-modifiable risk factor but it is estimated that over half of CRC cases are linked with lifestyle factors such as diet. The Biomarkers Of RIsk of Colorectal Cancer (BORICC) Study recruited 363 participants in 2005 to investigate the effects of lifestyle factors on biomarkers of CRC risk. Aim: In the present BORICC Follow-Up (BFU) Study, we are using a longitudinal study design to investigate the effects of ageing (12+ years) and lifestyle factors on biomarkers of CRC risk and on healthy ageing. Methods: BFU Study participants attended a study visit at North Tyneside General Hospital (UK) for collection of biological samples, including blood and rectal biopsies, and information collected included anthropometric measurements, a Health & Medications Questionnaire, physical activity and sedentary behaviour, and habitual diet. Furthermore, musculoskeletal function was assessed by heel bone densitometry, timed up and go and hand grip strength as markers of healthy ageing. The BFU Study outcomes will be similar to those measured at baseline in the BORICC Study, such as DNA methylation and mitochondrial function, with additional measurements including the gut microbiome, faecal short-chain fatty acid concentrations and expression of genes associated with CRC. Results: Participants’ recruitment to BFU Study and all sample and data collection have been completed. Forty-seven of the original BORICC participants were re-recruited to the BFU Study (mean age 67 years, 51% female). The recruits included 37 initially healthy participants and 10 participants who had adenomatous polyps at baseline. Approximately 70% of participants were over-weight or obese. Conclusion: Ultimately, identifying lifestyle factors that can reduce CRC risk, and understanding the underlying mechanisms for the effects of lifestyle and ageing on CRC risk, could lead to early prevention strategies.
Radiofrequency ablation using injectable cooled electrode: the effects of lidocaine injection in ex vivo study
Authors: Park Sun-Young , Chung Hye Won , Baek Jung Hwan , Lee Jeong Hyun , Lee Min Hee , Lee Joon Woo 
Published: August 2019

Background Pain control is needed during radiofrequency ablation in musculoskeletal tumor. The effect of radiofrequency ablation can be modulated by lidocaine injection. Purpose To evaluate the effects of injectable electrodes with intralesional lidocaine injection and compare its ablation performance with that of non-injectable electrodes in ex vivo pork sirloin. Material and Methods Five specimen groups were used to investigate the effects of fluid injection before radiofrequency ablation using injectable and non-injectable electrodes: three injectable electrode comparison groups with 2% lidocaine (group A); 1% lidocaine (group B); 0.9% sodium chloride (group C); injectable electrode reference group without fluid (group D); and non-injectable electrode control group (group E). The injectable and non-injectable electrodes were 17-gauge electrodes each having a 1-cm active tip. Technical parameters, ablation size, and volumes were compared between the five groups. Results Mean energies and currents during radiofrequency ablation were significantly lower for the four injectable electrode groups compared to group E (all P < 0.005). Two transverse diameters, vertical diameter, and volumes in the four injectable electrode groups were significantly smaller than those in group E (all P < 0.05). Among the injectable electrode groups, volumes and two transverse diameters were significantly smaller in group A than in group D (all P < 0.05). Conclusions A slightly smaller ablation zone is obtained when lidocaine injection is performed before radiofrequency ablation using an injectable electrode compared to a non-injectable electrode.
Food Service Guideline Policies on Local Government–Controlled Properties
Authors: Zaganjor Hatidza , Bishop Kendrick Katherine , Onufrak Stephen , Ralston Aoki Julie , Whitsel Laurie P. , Kimmons Joel 
Published: August 2019

Purpose: Local governments can implement food service guideline (FSG) policies, which, in large cities, may reach millions of people. This study identified FSG policies among the 20 largest US cities and analyzed them for key FSG policy attributes. Design: Quantitative research. Setting: Local government facilities. Participants: Twenty largest US cities. Measures: Frequency of FSG policies and percent alignment to tool. Analysis: Using municipal legal code libraries and other data sources, FSG policies enacted as of December 31, 2016, were identified. Full-text reviews were conducted of identified policies to determine whether they met inclusion criteria. Included policies were analyzed for key policy attributes specific to nutrition, behavioral design, implementation, and facility efficiency. Results: Searches identified 469 potential FSG policies, of which 6 policies across 5 cities met inclusion criteria. Five policies met a majority of criteria assessed by the classification tool. Overall alignment to the tool ranged from 17% to 88%. Of the 6 policies, 5 met a majority of the nutrition attributes and 5 met at least 50% of attributes associated with implementation. No policies met the attributes associated with facility efficiency. Conclusion: The FSG policies were identified in 5 of the 20 US cities. Policy alignment was high for nutrition and implementation attributes. This analysis suggests that when cities adopt FSG policies, many develop policies that align with key policy attributes. These policies can serve as models for other jurisdictions to create healthier food access through FSGs.
Word Reading in Boys With Isolated Oral Clefts: Comparison to Unaffected Average and Dyslexic Readers Using the Dual-Route Model
Authors: Kuhlmann Emily Hope , Conrad Amy Lynn 
Published: August 2019

Objective:To examine word reading performance between boys with isolated cleft lip and/or palate (iCL/P), unaffected average reading (uAR), and unaffected impaired reading (uIR), using the dual-route model.Design:Case/control study.Setting:University children’s hospital.Participants:Males, between the ages of 8 to 11 years, with iCL/P (n = 26), uIR (n = 33), or uAR (n = 28).Methods:Single word reading and achievement were evaluated. Analyses of variance and analyses of covariance evaluated group differences in achievement. Medical records were reviewed for iCL/P participants for audiology and speech history. Spearman ρ correlations were calculated between hearing, speech, and reading achievement for the iCL/P group.Main Outcome Measure(s):Reading performance was evaluated using select subscales from the Woodcock Johnson Reading Mastery Test, 3rd Edition and the Test of Orthographic Competence.Results:Participants with iCL/P had higher than expected rates of reading impairment, differing across cleft type (0% iCL, 50% isolated cleft lip and palate [iCLP], 71.4% isolated cleft palate only [iCP]). On measures of word reading accuracy, iCL/P participants outscored uIR participants, with uAR participants scoring the highest. This pattern was specific to nonlexical reading tasks. Participants in the uAR and iCL/P groups outscored uIR participants on lexical tasks, with no significant differences between uAR and iCL/P. Evaluation of speech and hearing revealed no significant relationship to single word reading or achievement measures in the iCL/P group.Conclusions:Boys with iCL/P are at a higher risk of reading impairments, particularly within the iCP subset. Regular screening should be encouraged, with skills from both lexical and nonlexical routes assessed.
The Combined Effect of Body Mass Index and Tibial Slope Angles on Anterior Cruciate Ligament Injury Risk in Male Knees: A Case-Control Study
Authors: Kızılgöz Volkan , Sivrioğlu Ali Kemal , Aydın Hasan , Ulusoy Gökhan Ragıp , Çetin Türkhun , Tuncer Kutsi 
Published: August 2019

Introduction: Tibial slope angles (TSAs) have been identified as potential risk factors of anterior cruciate ligament (ACL) injury in the literature. A higher body mass index (BMI) might increase the risk of ACL tear because of greater axial compressive force. The aim of this study was to determine the relationship of these factors and the combined effect of BMI and TSA in determination of risk potential for ACL injury. Methods: The preoperative magnetic resonance (MR) images of 81 ACL-injured male knees and of 68 male individuals with no ACL injuries were evaluated by 2 radiologists to measure the TSA. The Mann-Whitney U-test was performed to indicate the significant difference in height, weight, and BMI values. The independent samples t-test was used to determine the differences between ACL-injured and non-injured groups regarding TSA values. Odds ratios were calculated by logistic regression tests, and receiver operating characteristics (ROC) curves revealed the area under the receiver operating characteristics curve (AUC) values to compare the relationships of these parameters with ACL injury. Results: Body mass index, lateral tibial slope (LTS), and medial tibial slope (MTS) were predictive of ACL risk injury. Body mass index alone had the greatest effect among these parameters, and there were no statistically significant differences in coronal tibial slope values between the ACL-ruptured and control groups. The greatest AUC was observed for the combination of BMI, MTS, and LTS. Conclusions: Body mass index, LTS, and MTS angles were associated with ACL injury risk and BMI + MTS + LTS together revealed the greatest effect on ACL injury.