bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Kinect V2 for elbow range of motion estimation in people with haemophilia using an angle correction model
Authors: Mateo Fernando , Carrasco Juan J. , Aguilar‐Rodríguez Marta , Soria‐Olivas Emilio , Bonanad Santiago , Querol Felipe , Pérez‐Alenda Sofía 
Published: April 2019

IntroductionThe joint range of motion (ROM) is an important clinical parameter used to assess the loss of functionality resulting from joint bleedings in people with haemophilia. These episodes require a close follow‐up and, to decrease patients' hospital dependence, telemedicine tools are needed. Therefore, this study is aimed to analyse the validity of the Microsoft Kinect V2 sensor with corrected angle measurement to be used in the monitoring of elbow ROM in people with haemophilia.MethodsA convenience sample of 10 healthy controls (CG) and 10 patients with haemophilia with elbow arthropathy (HG) participated in this study. Full ROM of elbow joints was measured in the frontal view with a 10‐degree sweep using: (a) a clinical goniometer; (b) the Kinect V2; (c) the Kinect V2 with angle correction; and (d) using a photograph. Bland‐Altman graphs (mean and 95% Limits of Agreement [LOA]) and Wilcoxon test were used to determine differences between measurements and groups.ResultsThe angle‐corrected Kinect V2 measurement removed the skew in the original data, reducing the average errors from 7.9° (LoA = −10.3°; 26.0°; CG) and 9.5° (LoA = −7.9°; 26.9°; HG) to −0.1° (LoA = −8.1°; 7.9°; CG) and −0.7° (LoA = −10.7°; 9.3°; HG).ConclusionsThese error levels allow the use of Kinect V2 in the clinical practice. Kinect V2 with angle correction can complement the classical goniometry allowing an efficient and touchless measurement of ROM.
Regional variation and cost implications of prescribed extended half‐life factor concentrates among U.S. Haemophilia Treatment Centres for patients with moderate and severe haemophilia
Authors: Croteau Stacy E. , Cheng Dunlei , Cohen Alice J. , Holmes Chris E. , Malec Lynn M. , Silvey Michael , Thornburg Courtney D. , Wheeler Allison P. , Kouides Peter A. , Raffini Leslie J. , Neufeld Ellis J. 
Published: April 2019

BackgroundExtended half‐life (EHL) factor VIII (FVIII) and IX (FIX) products are intended to decrease the burden of prophylaxis for patients with haemophilia A or B. Whether these newer concentrates have led to meaningful clinical practice change remains vague.AimTo characterize the longitudinal use of standard (SHL) and EHL factor concentrates at haemophilia treatment centres (HTCs), using the ATHNdataset, a US database of 138 ATHN‐affiliated HTCs.MethodsFactor concentrate use among moderate and severe haemophilia A and B patients without inhibitors was analysed at three time points over 18 months.ResultsUse of EHL concentrates rose from 10% of patients to 22% during this study. EHL FVIII prophylaxis is prescribed to the minority of patients, 28%; EHL FIX now predominates for prophylaxis, 52%. Rates of prescribed EHL products varied significantly by age group and HTC region. Median prescribed prophylaxis for SHL compared to EHL products was FVIII 6240 and 5200 and FIX 6968 and FIX 3900 IU/kg/y, respectively. On‐demand EHL use has grown but has minimal contribution to overall usage (2%).ConclusionHaemophilia treatment centre region and patient age impact the rate of adoption of EHL products; however, EHL prescribing continues to rise nationally, particularly for EHL FIX. Careful attention to annual cost of prophylaxis is imperative as the decrease in median EHL prophylaxis consumption is not offset by the higher unit cost of these products. It is unclear how further growth in use of EHLs will be impacted by emerging non‐factor replacement and gene therapies.
Tracing Imprints of the Border in the Territorial, Justice and Welfare Domains: A Multi‐Site Ethnography
Authors: ALIVERTI ANA , MILIVOJEVIC SANJA , WEBER LEANNE 
Published: April 2019

AbstractStarting from the border as an ‘epistemic viewpoint’ (Mezzadra and Neilson 2013), we seek to achieve conceptual depth about the nature of contemporary bordering practices by combining and re‐evaluating empirical data collected within different bordering domains. We build on Mezzadra and Neilson's concept of the ‘proliferation of borders’ by extending our focus to the impact of borders on individuals, arguing that border crossers experience an ‘accumulation of borders’ as borders are ‘imprinted’ on their bodies through multiple and diverse encounters with various state agencies. By tracing the imprint of the border and its impact on the lives of border crossers in a range of contexts (the territorial, justice, and welfare domain), we bring to light continuities in the governance of global mobility and the cumulative effects of borders that could not be captured by researching isolated, local sites within the nation‐state.
The labour market effects of applied service regimes and service sector reforms
Authors: SHINGAL Anirudh , SAUVÉ Pierre 
Published: April 2019

AbstractThis article offers novel insights into the modal and sectoral characteristics of trade in services that may exert an influence on the redistributive properties of liberalization in service trade and investment. It uses descriptive statistics, and econometric analysis to examine the labour market effects of unilateral service regimes, drawing on data from the OECD's Services Trade Restrictiveness Index for a sample of 44 OECD and non‐OECD countries and 22 sectors over the period 2014–16. Whereas the findings suggest that the unilateral liberalization of services is not associated with net labour displacement effects, the authors call for empirical evidence, based on improved data sources, for a fuller understanding of this issue.
Volatilidad en los ingresos y en el mercado de trabajo de los jóvenes en Europa
Authors: AYLLÓN Sara , RAMOS Xavier 
Published: April 2019

ResumenLos autores ofrecen nuevos datos empíricos sobre la volatilidad en los ingresos y en el mercado de trabajo (incluyendo entradas y salidas del empleo) de los jóvenes en Europa durante la Gran Recesión. Los datos de EU‐SILC para el periodo 2004–2013 revelan grandes disparidades al respecto entre los países europeos. La Gran Recesión incrementó la volatilidad entre los jóvenes. Mediante un ejercicio de descomposición de la varianza se observa una mayor rotación laboral en el sur de Europa. Según un modelo de efectos fijos, un mayor nivel de prestaciones de desempleo y de protección del empleo se asocia con una reducción de la volatilidad.
The service triangle and power: the role of frontline home support workers and consumer‐directed care—an Australian context
Authors: Payne Graeme , Fisher Greg 
Published: April 2019

AbstractWorkplace relational dynamics change when the customer or client takes on greater power in the relationship. Adopting a typology of the service triangle, this qualitative study examines frontline home support workers' perceptions of their power, following recent legislative change from a traditional agency‐directed aged care model to consumer‐directed care.
Evaluation of reference genes for quantitative real‐time PCR analysis of messenger RNAs and microRNAs in rainbow trout Oncorhynchus mykiss under heat stress
Authors: Ma Fang , Liu Zhe , Huang Jinqiang , Kang Yujun , Wang Jianfu 
Published: April 2019

AbstractWe assessed the expression stability of several messenger (m)RNAs and micro (mi)RNAs from liver and head kidney of rainbow trout Oncorhynchus mykiss using high‐throughput RNA sequencing (RNA‐seq) and miRNA‐seq data. Additionally, four commonly used reference genes and one small non‐coding RNA (u6) were also selected to identify ideal reference mRNAs and miRNAs for quantitative real‐time (qrt)‐PCR analysis of heat stress responses. GeNorm, NormFinder, BestKeeper and comparative ΔCt were employed for analysis of qrt‐PCR data to systematically assess the expression stability of candidate mRNAs and miRNAs and stability was ranked using geometric means. β‐actin and ef1‐α were the most stably expressed reference mRNAs in liver and head kidney, respectively and ssa‐mir‐26a‐5p and ssa‐mir‐462b‐5p were the most stably expressed miRNAs in these tissues. This is the first identification of appropriate reference mRNAs and miRNAs for qrt‐PCR analysis of O. mykiss under heat stress.
Development of a novel 2D single coffee bean model and comparison with a 3D model under varying heating profiles
Authors: Abdul Ghani Nur Hamizah , Bingol Gokhan , Li Bing , Yu Wei , Young Brent 
Published: April 2019

AbstractCoffee roasting produces several hundreds of aroma compounds that affect its quality. A good roasting model can not only help to control the required energy to reduce the process cost, but also ensure the product quality by cooperating with process analytical technologies and model predictive control strategies. However, current coffee roasting models are limited to constant heating temperature application due to high computational cost. Current research is developing a 2D roasting model of a single bean under varying heating profiles and is comparing it with the commonly used 3D model. The 2D model is designed to achieve minimum discrepancies with experimental data using estimated parameters of the bean's thermal conductivity and moisture diffusivity. The model performance showed that the 2D model was able to solve much faster than a 3D model, while the absolute difference in the bean temperature prediction between these two models was less than 5°C. The proposed 2D model shows potential in monitoring the roasted coffee bean quality, where it can provide a cost efficient and reliable bean temperature prediction.Practical applicationsThe application of varying heating profiles can optimize the flavor of roasted coffee beans. This study had developed a 2D model that can efficiently simulate under varying heating conditions. The 2D model also provides comparable accuracy to the 3D model and therefore, proving of its potential to be used in the modeling of batch coffee roasting.
Habitat use and vestibular system's dimensions in lacertid lizards
Authors: Vasilopoulou‐Kampitsi Menelia , Goyens Jana , Baeckens Simon , Van Damme Raoul , Aerts Peter 
Published: April 2019

Abstract
The vestibular system is crucial for movement control during locomotion. As the dimensions of the vestibular system determine the fluid dynamics of the endolymph and, as such, the system's function, we investigate the interaction between vestibular system size, head size and microhabitat use in lizards. We grouped 24 lacertid species in three microhabitat types, we acquired three‐dimensional models of the bony vestibular systems using micro‐computer tomography scanning, and we performed linear and surface measurements. All vestibular measurements scale with a negative allometry with head size, suggesting that smaller heads house disproportionally large ears. As the sensitivity of the vestibular system is positively related to size, a sufficiently large vestibular system in small‐headed animals may meet the sensitivity demands during challenged locomotion. We also found that the microhabitat affects the locomotor dynamics: lizards inhabiting open microhabitats run at higher dimensionless speeds. On the other hand, no statistical relationship exists between dimensionless speed and the vestibular system dimensions. Hence, if the vestibular size would differ between microhabitats, this would be a direct effect (i.e. imposed, for instance, by requirements for manoeuvring, balance control, etc.), rather than depending on the lizards’ intrinsic running speed. However, we found no effect of the microhabitat on the allometric relationship between head and vestibular system size. The finding that microhabitat is not reflected in the vestibular system size (hence sensitivity) of the lacertids in this study is possibly due to spatial constraints of the skull.
The sandwich structure of keratinous layers controls the form and growth orientation of chicken rhinotheca
Authors: Urano Yukine , Sugimoto Yasunobu , Tanoue Kyo , Matsumoto Ryoko , Kawabe Soichiro , Ohashi Tomoyuki , Fujiwara Shin‐ichi 
Published: April 2019

AbstractThe upper beak bone of birds is known to be overlain by the rhinotheca, which is composed of the horny sheath of keratinous layers. However, the details of the structure and growth pattern of the rhinotheca are yet to be understood. In this study, the microstructure of the rhinotheca from chicken specimens of different growth stages (ranging from 1 to ~ 80 days old) was analyzed using a combination of thin section and scanning electron microscopy observations, and small‐angle X‐ray scattering analysis. We found that the rhinotheca comprises three different layers – outer, intermediate, and inner layers – throughout its growth. The outer layer arises from the proximal portion of the beak bone and covers the dorsal surface of the rhinotheca, whereas the intermediate and inner layers originate in the distal portion of the beak bone and underlie the outer layer. This tri‐layered structure of the rhinotheca was also observed in wild bird specimens (grey wagtail, king quail, and brown dipper). On the median plane, micro‐layers making up the outer and inner layers are bedded nearly parallel to the rostral bone at the base. However, more distally positioned micro‐layers of the outer layer are more anteverted distally. The micro‐layers of the intermediate layer are bedded nearly perpendicular to those of the outer and inner layers on the median plane. The growth of micro‐layers in the intermediate layer adds thickness to the rhinotheca, which causes the difference in profile between the beak bone and the rhinotheca in the distal portion of the beak. Moreover, the entire intermediate layer grows distally as new proximal micro‐layers form. The outer layer is dragged distally by the intermediate layer as a result of its distal growth, for the three layers are closely packed to each other at their boundaries. Furthermore, the occurrence of the intermediate and inner layers in the distal portion of the rostral bone may be because the distal end of the beak is frequently used and worn, and the rhinotheca therefore needs to be replaced more frequently at the distal end. The rhinotheca structure described here will be an important and useful factor in the reconstruction of the beaks of birds in extinct taxa.
Network reconfiguration: The implications of recognizing top performers in teams
Authors: Zheng Xiaoming , Zhao Helen H. , Liu Xin , Li Ning 
Published: April 2019

Social recognition programme is a frequently used motivational tool in organizations. It serves two purposes: to recognize award recipients’ exceptional performance, and to motivate other employees to work hard for future social recognition. However, when work is interdependent, recognizing just one team member but not others constitutes a salient social comparison situation. In this study, we introduce a generalized concept of network reconfiguration. In a field experiment, we track dyadic interactions before and after social recognition of the top performers in teams, and document substantial changes in teams’ social network structures during this period of time. Using latent change score modelling to test for the presence of network reconfiguration at individual (i.e., centrality) and team (i.e., density) levels of analysis, we find that socially recognizing a top performer does, in fact, influence network reconfiguration processes. In our study context, the network reconfiguration process takes place around the top performer, with team members becoming significantly less connected with him or her. We also find a negative impact on team performance for teams that experience higher levels of network reconfiguration due to team procedural injustice.Practitioner pointsSocial recognition programmes may have unintended effects on network reconfiguration.Socially recognizing a top performer affects network reconfiguration processes.Team performance can decline after network reconfiguration due to procedural injustice.
A novel in situ bone elevation method to achieve vertical periodontal augmentation in dogs: A pilot study
Authors: Li Lili , Su Wenqi , Xie Xiaoting , Lei Lang , Bao Jun , He Shasha , Chen Sheng , Yang Yan , Yan Fuhua , Li Houxuan 
Published: April 2019

AbstractObjectivesThe purpose of this study was to investigate whether a novel in situ interdental bone elevation method could achieve vertical bone augmentation around natural teeth.MethodsHorizontal periodontal bone defects were created at nine quadrants of mandibles in five dogs. Six weeks later, one of the nine quadrants was randomly chosen as the model control. The remaining mandibles were allocated into two experimental groups: cortical bone removing (CBR) or interdental bone elevation (IBE). For the IBE group, four millimetres of interdental bone blocks were separated and elevated from the base of alveolar bone. Then bone xenografts were implanted beneath the elevated alveolar blocks. Animals were euthanised 12 weeks post‐operation. Cone beam computed tomography (CBCT) examination and histological analysis were performed to evaluate the surgical outcomes.ResultsEnhanced soft tissue profiles were observed in the two experimental groups as compared to the model control group. CBCT images showed that the height of alveolar bone was significantly higher in the IBE group with bone blocks seated near the cementoenamel junction. Significantly larger area of bone tissues with the highest coronal level of new bone was observed in the IBE group. New bone was observed around the elevated bone blocks with bone remodelling and neovascularisation inside the elevated blocks.ConclusionsVertical bone augmentation at interdental sites may be performed through in situ interdental bone elevation for patients with horizontal alveolar bone resorption.
Examining the role of cognitive fusion and experiential avoidance in predicting anxiety and depression
Authors: Cookson Camilla , Luzon Olga , Newland John , Kingston Jessica 
Published: April 2019

ObjectivesAcceptance and Commitment Therapy (ACT) proposes that cognitive fusion and experiential avoidance are inter‐related processes underpinning distress. This study investigated whether worry, rumination, and stressful life events on the one hand and anxiety and depression on the other hand were mediated by cognitive fusion and experiential avoidance (bidirectional serial association).DesignA questionnaire design was conducted cross‐sectionally in a clinical sample (study 1; N = 57) and cross‐sectionally and longitudinally in a non‐clinical student sample (study 2; N = 106 and N = 97 respectively).MethodsParticipants completed measures of worry, rumination, stressful life events (predictors), cognitive fusion, experiential avoidance (mediators), anxiety, and depression (outcomes) at T1. In study 2, anxiety and depression were measured again 6 weeks later.ResultsIn the clinical sample, the bidirectional relationship between experiential avoidance and cognitive fusion accounted for a significant proportion of the association between rumination and depression, and stressful life events and anxiety and depression. The association between worry and anxiety was mediated by cognitive fusion → experiential avoidance only. In the non‐clinical sample, in both cross‐sectional and longitudinal analyses, cognitive fusion independently mediated the association between predictors and outcomes, as well as the experiential avoidance → cognitive fusion pathway.ConclusionsThe bidirectional association between cognitive fusion and experiential avoidance was most predictive of distress in the clinical sample. In the non‐clinical sample, cognitive fusion and the experiential avoidance → cognitive fusion pathway demonstrated more explanatory value. Given the cross‐sectional nature of most of the data, the findings provide theoretical (as opposed to empirical) support for the models tested.Practitioner points

Interventions designed to reduce cognitive fusion may be a useful early intervention for sub‐clinical anxiety and depression.

Interventions focused on reducing both cognitive fusion and experiential avoidance may be helpful for individuals presenting with clinical anxiety and depression.

Individuals presenting with particularly high levels of experiential avoidance may benefit from initial work defusing from difficult thoughts, as an inroad for reducing experiential avoidance, anxiety, and depression. Likewise, those with rigid cognitive fusion may benefit from initial work around acceptance skills to create a context that better supports defusion.
Novel molecular insights into the anti‐oxidative stress response and structure–function of a salt‐inducible cyanobacterial Mn‐catalase
Authors: Chakravarty Dhiman , Bihani Subhash C. , Banerjee Manisha , Ballal Anand 
Published: April 2019

AbstractKatB, a salt‐inducible Mn‐catalase, protects the cyanobacterium Anabaena from salinity/oxidative stress. In this report, we provide distinctive insights into the biological–biochemical function of KatB at the molecular level. Anabaena overexpressing the wild‐type KatB protein (KatBWT) detoxified H2O2 efficiently, showing reduced burden of reactive oxygen species compared with the strain overproducing KatBF2V (wherein F‐2 is replaced by V). Correspondingly, the KatBWT protein also displayed several folds more activity than KatBF2V. Interestingly, the KatB variants with large hydrophobic amino acids (F/W/Y) were more compact, showed enhanced activity, and were resistant to thermal/chemical denaturation than variants with smaller residues (G/A/V) at the second position. X‐ray crystallography‐based analysis showed that F‐2 was required for appropriate interactions between two subunits. These contacts provided stability to the hexamer, making it more compact. F‐2, through its interaction with F‐66 and W‐43, formed the proper hydrophobic pocket that held the active site together. Consequently, only residues that supported activity (i.e., F/Y/W) were selected at the second position in Mn‐catalases during evolution. This study (a) demonstrates that modification of nonactive site residues can alter the response of catalases to environmental stress and (b) has expanded the scope of amino acids that can be targeted for rational protein engineering in plants.
The capacity to emit isoprene differentiates the photosynthetic temperature responses of tropical plant species
Authors: Taylor Tyeen C. , Smith Marielle N. , Slot Martijn , Feeley Kenneth J. 
Published: April 2019

AbstractExperimental research shows that isoprene emission by plants can improve photosynthetic performance at high temperatures. But whether species that emit isoprene have higher thermal limits than non‐emitting species remains largely untested. Tropical plants are adapted to narrow temperature ranges and global warming could result in significant ecosystem restructuring due to small variations in species' thermal tolerances. We compared photosynthetic temperature responses of 26 co‐occurring tropical tree and liana species to test whether isoprene‐emitting species are more tolerant to high temperatures. We classified species as isoprene emitters versus non‐emitters based on published datasets. Maximum temperatures for net photosynthesis were ~1.8°C higher for isoprene‐emitting species than for non‐emitters, and thermal response curves were 24% wider; differences in optimum temperatures (Topt) or photosynthetic rates at Topt were not significant. Modelling the carbon cost of isoprene emission, we show that even strong emission rates cause little reduction in the net carbon assimilation advantage over non‐emitters at supraoptimal temperatures. Isoprene emissions may alleviate biochemical limitations, which together with stomatal conductance, co‐limit photosynthesis above Topt. Our findings provide evidence that isoprene emission may be an adaptation to warmer thermal niches, and that emitting species may fare better under global warming than co‐occurring non‐emitting species.