bluuebunny/crossref_metadata_2025_split huggingface dataset:
Between cooperation and survival
Authors: Kim JongHo 
Published: October 2018

Purpose
The purpose of this paper is to investigate the survival capability of Chaoshan people in the maritime world of the South China Sea amidst the changing monetary systems of the rival empires and political regimes from 1939 to 1945. It particularly focuses on overseas Chinese remittance business in Shantou under the Japanese rule. Local societies in coastal China and overseas Chinese communities in Southeast Asia experienced severe hardships due to the Sino-Japanese War, the Pacific War and the Chinese Civil War. As fighting among the rival empires and regimes intensified, Chinese migrant communities straddling between Southeast Asia and South China had to negotiate and adapt to survive these crises, regardless of whether they were government-affiliated or local autonomous subjects.

Design/methodology/approach
This research draws on archival materials to investigate the reactions of Chinese migrant communities in Chaoshan region in times of war and regime change. How did local maritime societies and overseas Chinese adapt to the harsh realities of the wartime? How did the Japanese Empire use Wang Jingwei’s puppet government in Nanjing to control the Chaoshan remittance network? How did the remittance network shift its operational structure in face of a wartime crisis?

Findings
Faced with the wartime crisis and the Japanese occupation, Chaoshan communities used a variety of survival strategies to protect and maintain the overseas Chinese remittance business. In dealing with remittances from Singapore, British Malay and Indonesia, they cooperated with the Japanese military authority and its puppet government to maximize the autonomy of their business operation in the Japanese-controlled East Asian Co-prosperity Sphere. On the other hand, to secure the flow of remittances from French Indochina and Thailand, the indirectly controlled territories in the Japanese Empire, Chaoshan merchants sought an alternative path of delivering remittances, known as the Dongxing route, to bypass the Japanese ban on private remittances from these two regions.

Research limitations/implications
It would be a better research if more resources, including remittance receipts and documents during the Japanese occupation, could be found and used to show more detailed features of Chaoshan local society.

Originality/value
This research is the first one to investigate the contradictory features of local Chaoshan society during the Japanese occupation, an under-explored subject in the Chinese historiography.
Innovation platforms fostering low-carbon economy resource mobilisation
Authors: Vivas Lalinde Irene , Matti Cristian , Panny Julia , Juan Agulló Blanca 
Published: October 2018

Purpose
The purpose of this paper is to highlight the potential of innovation platforms to realise SDGs targets by focussing in sustainable innovation process related to infrastructure and industrialisation.

Design/methodology/approach
Analysis of different policy documents, reports as well as a series of interviews and participatory processes run in 2016–2017 of the EIT Regional Innovation Scheme programme to prototype a knowledge triangle integration (KTI) index.

Findings
Preliminary findings show that EIT Climate-KIC operates as an innovation platform that mobilise resources to increases capabilities for climate innovation.

Practical implications
The paper contributes to a better understanding of the complexity of the efforts needed to tackle climate innovation regarding resource mobilisation for KTI processes by focussing on how platforms work in a bottom-up way.

Originality/value
Mechanisms and processes that consolidate local knowledge and strengthen relational assets with regards to climate innovation are important for the realisation of some of the 169 targets of the 2030 Agenda.
Kleptoplastidic benthic foraminifera from aphotic habitats: insights into assimilation of inorganic C, N and S studied with sub‐cellular resolution
Authors: Jauffrais Thierry , LeKieffre Charlotte , Schweizer Magali , Geslin Emmanuelle , Metzger Edouard , Bernhard Joan M. , Jesus Bruno , Filipsson Helena L. , Maire Olivier , Meibom Anders 
Published: October 2018

SummaryThe assimilation of inorganic compounds in foraminiferal metabolism compared to predation or organic matter assimilation is unknown. Here, we investigate possible inorganic‐compound assimilation in Nonionellina labradorica, a common kleptoplastidic benthic foraminifer from Arctic and North Atlantic sublittoral regions. The objectives were to identify the source of the foraminiferal kleptoplasts, assess their photosynthetic functionality in light and darkness and investigate inorganic nitrogen and sulfate assimilation. We used DNA barcoding of a ~ 830 bp fragment from the SSU rDNA to identify the kleptoplasts and correlated transmission electron microscopy and nanometre‐scale secondary ion mass spectrometry (TEM‐NanoSIMS) isotopic imaging to study 13C‐bicarbonate, 15N‐ammonium and 34S‐sulfate uptake. In addition, respiration rate measurements were determined to assess the response of N. labradorica to light. The DNA sequences established that over 80% of the kleptoplasts belonged to Thalassiosira (with 96%–99% identity), a cosmopolitan planktonic diatom. TEM‐NanoSIMS imaging revealed degraded cytoplasm and an absence of 13C assimilation in foraminifera exposed to light. Oxygen measurements showed higher respiration rates under light than dark conditions, and no O2 production was detected. These results indicate that the photosynthetic pathways in N. labradorica are not functional. Furthermore, N. labradorica assimilated both 15N‐ammonium and 34S‐sulfate into its cytoplasm, which suggests that foraminifera might have several ammonium or sulfate assimilation pathways, involving either the kleptoplasts or bona fide foraminiferal pathway(s) not yet identified.
High single‐cell diversity in carbon and nitrogen assimilations by a chain‐forming diatom across a century
Authors: Olofsson Malin , Kourtchenko Olga , Zetsche Eva‐Maria , Marchant Hannah K. , Whitehouse Martin J. , Godhe Anna , Ploug Helle 
Published: October 2018

SummaryAlmost a century ago Redfield discovered a relatively constant ratio between carbon, nitrogen and phosphorus in particulate organic matter and nitrogen and phosphorus of dissolved nutrients in seawater. Since then, the riverine export of nitrogen to the ocean has increased 20 fold. High abundance of resting stages in sediment layers dated more than a century back indicate that the common planktonic diatom Skeletonema marinoi has endured this eutrophication. We germinated unique genotypes from resting stages originating from isotope‐dated sediment layers (15 and 80 years old) in a eutrophied fjord. Using secondary ion mass spectrometry (SIMS) combined with stable isotopic tracers, we show that the cell‐specific carbon and nitrogen assimilation rates vary by an order of magnitude on a single‐cell level but are significantly correlated during the exponential growth phase, resulting in constant assimilation quota in cells with identical genotypes. The assimilation quota varies largely between different clones independent of age. We hypothesize that the success of S. marinoi in coastal waters may be explained by its high diversity of nutrient demand not only at a clone‐specific level but also at the single‐cell level, whereby the population can sustain and adapt to dynamic nutrient conditions in the environment.
Contribution of structural recalcitrance to the formation of the deep oceanic dissolved organic carbon reservoir
Authors: Wang Nannan , Luo Ya‐Wei , Polimene Luca , Zhang Rui , Zheng Qiang , Cai Ruanhong , Jiao Nianzhi 
Published: October 2018

SummaryThe origin of the recalcitrant dissolved organic carbon (RDOC) reservoir in the deep ocean remains enigmatic. The structural recalcitrance hypothesis suggests that RDOC is formed by molecules that are chemically resistant to bacterial degradation. The dilution hypothesis claims that RDOC is formed from a large diversity of labile molecules that escape bacterial utilization due to their low concentrations, termed as RDOCc. To evaluate the relative contributions of these two mechanisms in determining the long‐term persistence of RDOC, we model the dynamics of both structurally recalcitrant DOC and RDOCc based on previously published data that describes deep oceanic DOC degradation experiments. Our results demonstrate that the majority of DOC (84.5 ± 2.2%) in the deep ocean is structurally recalcitrant. The intrinsically labile DOC (i.e., labile DOC that rapidly consumed and RDOCc) accounts for a relatively small proportion and is consumed rapidly in the incubation experiments, in which 47.8 ± 3.2% of labile DOC and 21.9 ± 4.6% of RDOCc are consumed in 40 days. Our results suggest that the recalcitrance of RDOC is largely related to its chemical properties, whereas dilution plays a minor role in determining the persistence of deep‐ocean DOC.
The BRICS Coming of Age and the New Development Bank
Authors: Suchodolski Sergio Gusmão , Demeulemeester Julien Marcel 
Published: October 2018

AbstractThe robust economic growth of developing countries revived discussions about the need for a global financial architecture that is more representative of today's economic and political realities. The world is now markedly different from the moment the Bretton Woods institutions were created. The BRICS now account for a substantive share of global GDP, however, this was not reflected in equivalent voting power in existing multilateral institutions. As a response, they created institutions like the New Development Bank (NDB) and the Contingent Reserve Agreement (CRA), symbolizing a shift of economic and political power towards emerging countries. Against this backdrop, this paper explores the growing importance of BRICS countries as contributors to the global economy and to global governance. Using NDB as a case‐study, the paper explores the origins of the Bank and attempts to answer why a new institution was needed, elaborating on five practical examples in which NDB could contribute with innovations to the modus operandi of multilateral development banking. The authors argue that out of all multilateral development banks created in the past decades, the NDB has the largest potential to catalyze changes in the Bretton Woods institutions and to grow as an alternative to them.
Evaluation of the prognostic value of surgery and postoperative radiotherapy for patients with thymic neuroendocrine tumors: A propensity‐matched study based on the SEER database
Authors: Wen Junmiao , Chen Jiayan , Chen Donglai , Liu Di , Xu Xinyan , Huang Lv , Cao Jianzhao , Zhang Junhua , Gu Yu , Fan Min , Chen Yongbing 
Published: October 2018

BackgroundThe prognostic value of surgery and postoperative radiotherapy (PORT) for primary thymic neuroendocrine tumors (TNETs) was estimated using the SEER database.MethodsThis retrospective study used SEER data of TNET patients between 1998 and 2015. Propensity score matching (PSM) was performed according to whether surgery was performed. The prognostic effects on overall survival (OS) and cancer‐specific survival (CSS) were evaluated using multivariate Cox regression.ResultsA total of 3947 patients were included: 293 (7.4%) TNET, 2788 (70.6%) thymoma, and 866 (21.9%) thymic carcinoma. Compared to other subtypes, TNET patients were younger, included a larger proportion of men, had a well or moderately differentiated histological grade, higher disease stage at diagnosis, and were more likely to have regional lymph node metastasis. The median OS and CSS for TNET were 82.9 (95% confidence interval 74.3–91.4) and 101.9 (95% confidence interval 91.9–111.8) months, respectively, significantly shorter than for thymomas. In the matched cohort of TNET patients, multivariate analysis of OS and CSS revealed a significantly poorer prognosis in the non‐surgery group (P < 0.001). Compared to total/radical resection, TNET patients who underwent debulking resection had significantly inferior outcomes (P < 0.05). Postoperative radiotherapy favorably impacted OS and CSS in Masaoka–Koga stage III–IV TNET patients; this OS impact was also observed in stage IIB patients.ConclusionTNETs are extremely rare with relatively dismal outcomes. This analysis revealed the role of complete surgical resection and the favorable effect of postoperative radiotherapy in specific TNET subgroups.
Clinical complete response after chemoradiotherapy for carcinoma of thoracic esophagus: Is esophagectomy always necessary? A systematic review and meta‐analysis
Authors: Wang Jun , Qin Jianjun , Jing Shaowu , Liu Qing , Cheng Yunjie , Wang Yi , Cao Feng 
Published: October 2018

BackgroundAlthough a clinical complete response (cCR) after chemoradiotherapy (CRT) could lead to a better prognosis, the choice of a following strategy, such as surgical or non‐surgical approach, remains controversial.MethodsAll articles relevant to a comparison of surgical and non‐surgical treatment (including further definitive chemoradiotherapy or active surveillance) for esophageal carcinoma patients with a cCR after CRT were retrieved for meta‐analysis. The final date for data retrieval was 30 June 2018.ResultsFour retrospective studies including 648 patients met the inclusion criteria: 620 with squamous cell carcinoma and 28 with adenocarcinoma. The CRT + surgery group had an advantage over the non‐surgery group in regard to two‐year disease‐free survival (DFS); however, the two groups showed similar results in five‐year DFS. The CRT + surgery group had an advantage over the non‐surgery group in two‐year overall survival (OS); nevertheless, the two groups showed similar results in five‐year OS.ConclusionsBased on the available evidence, the addition of surgery to thoracic locally advanced esophageal carcinoma patients with a cCR after neoadjuvant CRT provided no advantage to long‐term survival. As an exception, the two‐year DFS and OS could be improved. This research conclusion might be more suitable to patients with squamous cell carcinoma.
Meta‐Analysis of Genetic Influences on Initial Alcohol Sensitivity
Authors: Edwards Alexis C. , Deak Joseph D. , Gizer Ian R. , Lai Dongbing , Chatzinakos Chris , Wilhelmsen Kirk P. , Lindsay Jonathan , Heron Jon , Hickman Matthew , Webb Bradley T. , Bacanu Silviu‐Alin , Foroud Tatiana M. , Kendler Kenneth S. , Dick Danielle M. , Schuckit Marc A. 
Published: October 2018

BackgroundPrevious studies indicate that low initial sensitivity to alcohol may be a risk factor for later alcohol misuse. Evidence suggests that initial sensitivity is influenced by genetic factors, but few molecular genetic studies have been reported.MethodsWe conducted a meta‐analysis of 2 population‐based genome‐wide association studies of the Self‐Rating of the Effects of Alcohol scale. Our final sample consisted of 7,339 individuals (82.3% of European descent; 59.2% female) who reported having used alcohol at least 5 times. In addition, we estimated single nucleotide polymorphism (SNP)‐based heritability and conducted a series of secondary aggregate genetic analyses.ResultsNo individual locus reached genome‐wide significance. Gene and set based analyses, both overall and using tissue‐specific expression data, yielded largely null results, and genes previously implicated in alcohol problems and consumption were overall not associated with initial sensitivity. Only 1 gene set, related to hormone signaling and including core clock genes, survived correction for multiple testing. A meta‐analysis of SNP‐based heritability resulted in a modest estimate of = 0.19 (SE = 0.10), though this was driven by 1 sample (N = 3,683, = 0.36, SE = 0.14, p = 0.04). No significant genetic correlations with other relevant outcomes were observed.ConclusionsFindings yielded only modest support for a genetic component underlying initial alcohol sensitivity. Results suggest that its biological underpinnings may diverge somewhat from that of other alcohol outcomes and may be related to core clock genes or other aspects of hormone signaling. Larger samples, ideally of prospectively assessed samples, are likely necessary to improve gene identification efforts and confirm the current findings.
A novel heterozygous variant p.(Trp538Arg) of SYNM is identified by whole‐exome sequencing in a Chinese family with dilated cardiomyopathy
Authors: Zhang Shu‐Bing , Liu Yu‐Xing , Fan Liang‐Liang , Huang Hao , Li Jing‐Jing , Jin Jie‐Yuan , Xiang Rong 
Published: October 2018

AbstractDilated cardiomyopathy (DCM) is a relatively frequent myocardial disease that may lead to heart failure, syncope, and sudden cardiac death. Genetic factors play important roles in the etiology of the disease. To date, at least 50 genes have been identified in patients with DCM, among them, only three mutations have been reported in Synemin (SYNM) gene. In this study, we investigate a Chinese family of three generations with four patients with DCM. Employing whole‐exome sequencing (WES) and bioinformatics strategies, a novel heterozygous missense mutation p.(Trp538Arg) of SYNM was identified and cosegregated with the affected family members. The missense mutation locates in the C‐terminal domain of SYNM and leads to a substitution of tryptophan by arginine and may cause the structure change of synemin protein. In conclusion, we employed WES to detect the mutations of DCM patients and identified a novel likely pathogenic mutation in SYNM gene. Our study not only expands the spectrum of SYNM mutations, it further confirms that mutations in SYMN may underlie nonfamilial DCM, and offers genetic testing information to additional DCM patients.
Public‐Sector Unions and the Size of Government
Authors: Paglayan Agustina S. 
Published: October 2018

AbstractPublic‐sector unions are generally thought to increase the size of government through collective bargaining. This article challenges this idea for the case of teacher unions in the United States and argues that while collective bargaining institutions sometimes lead to increased education spending, this is not the norm. Using a new longitudinal data set spanning all states before and after they granted collective bargaining rights to teachers, the article shows that although states that mandate districts to bargain with teachers have higher education expenditures than states that do not, the differences precede collective bargaining. Difference‐in‐differences analyses find no evidence that introducing collective bargaining rights led to average increases in the level of resources devoted to education. Although existing theories cannot explain these null findings, the article shows one reason behind them is that most laws granting collective bargaining rights to teachers were not unambiguously prolabor, but included both pro‐ and anti‐union provisions.
Impact of change in head and neck position on ultrasound localisation of the cricothyroid membrane: an observational study
Authors: Dixit A. , Ramaswamy K. K. , Perera S. , Sukumar V. , Frerk C. 
Published: October 2018

SummaryThe ideal position for performing surgical cricothyroidotomy is with full neck extension. Some authors have recommended marking the cricothyroid membrane before general anaesthesia, typically with the patient's head and neck in a neutral position. The primary aim of this observational study was to determine whether skin marks made over the centre of the cricothyroid membrane with the head and neck in the neutral position moved outside the boundaries of the membrane when the neck was subsequently extended. The secondary aim was to assess changes in the height of the cricothyroid membrane between the neutral and extended positions. Twenty‐two volunteers completed the study. With the head and neck in the neutral position, the distance between the upper and lower borders (‘height’) of the cricothyroid membrane was measured by a radiologist using ultrasound. The skin was marked over the mid‐point of the membrane. The subject then maximally extended the neck, and the measurements and marking were repeated. The skin marking over the centre point of the cricothyroid membrane moved by median (IQR [range]) 5 (4–6 [0–10]) mm when the head and neck were moved from a neutral to a fully extended position. The initial skin mark moved to lie outside the boundary of the cricothyroid membrane in 12 of 22 subjects after extending the neck. The height of the cricothyroid membrane increased by 30% with the neck extended. We recommend that marking the skin in preparation for cricothyroidotomy should be performed with the neck extended, not with the head and neck in the neutral position as previously suggested.
Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptor
Authors: Bird M F , Guerrini R , Willets J M , Thompson J P , Caló G , Lambert D G 
Published: October 2018

Background and PurposeThe nociceptin/orphanin FQ (N/OFQ) receptor (NOP) is a member of the opioid receptor family and is involved in a number of physiological responses, pain and immune regulation as examples. In this study, we conjugated a red fluorophore‐ATTO594 to the peptide ligand N/OFQ (N/OFQATTO594) for the NOP receptor and explored NOP receptor function at high (in recombinant systems) and low (on immune cells) expression.Experimental ApproachWe assessed N/OFQATTO594 receptor binding, selectivity and functional activity in recombinant (CHO) cell lines. Live cell N/OFQATTO594 binding was measured in (i) HEK cells expressing NOP and NOPGFP receptors, (ii) CHO cells expressing the hNOPGαqi5 chimera (to force coupling to measurable Ca2+ responses) and (iii) freshly isolated human polymorphonuclear cells (PMN).Key ResultsN/OFQATTO594 bound to NOP receptor with nM affinity and high selectivity. N/OFQATTO594 activated NOP receptor by reducing cAMP formation and increasing Ca2+ levels in CHOhNOPGαqi5 cells. N/OFQATTO594 was also able to visualize NOP receptors at low expression levels on PMN cells. In NOP‐GFP‐tagged receptors, N/OFQATTO594 was used in a FRET protocol where GFP emission activated ATTO, visualizing ligand–receptor interaction. When the NOPGFP receptor is activated by N/OFQATTO594, movement of ligand and receptor from the cell surface to the cytosol can be measured.Conclusions and ImplicationsIn the absence of validated NOP receptor antibodies and issues surrounding the use of radiolabels (especially in low expression systems), these data indicate the utility of N/OFQATTO594 to study a wide range of N/OFQ‐driven cellular responses.