bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEGREE-BASED GINI INDEX FOR GRAPHS
Authors: Domicolo Carly , Mahmoud Hosam 
Published: March 2019

AbstractIn Balaji and Mahmoud [1], the authors introduced a distance-based Gini index for rooted trees. In this paper, we introduce a degree-based Gini index (or just simply degree Gini index) for graphs. The latter index is a topological measure on a graph capturing the proximity to regular graphs. When applied across the random members of a class of graphs, we can identify an average measure of regularity for the class. Whence, we can compare the classes of graphs from the vantage point of closeness to regularity.We develop a simplified computational formula for the degree Gini index and study its extreme values. We show that the degree Gini index falls in the interval [0, 1). The main focus in our study is the degree Gini index for the class of binary trees. Via a left-packing transformation, we show that, for an arbitrary sequence of binary trees, the Gini index has inferior and superior limits in the interval [0, 1/4]. We also show, via the degree Gini index, that uniform rooted binary trees are more regular than binary search trees grown from random permutations.
Suppression of Annual Ryegrass in Corn with Nicosulfuron
Authors: Cholette Taïga B. , Soltani Nader , Hooker David C. , Robinson Darren E. , Sikkema Peter H. 
Published: March 2019

AbstractField studies were conducted to determine the possible rate and timing of nicosulfuron to suppress annual ryegrass (ARG) seeded as a cover crop at the time of corn planting without affecting corn performance near Ridgetown, ON, Canada, in 2016 and 2017. Nicosulfuron was applied at rates from 0.8 to 50 g ai ha–1when the ARG was at the two- to three- or four- to five-leaf stages, or approximately 3 or 4 wk after emergence of both corn and ARG. There were no differences between the two application timings in grain yield responses or ARG suppression. As the rate of nicosulfuron increased from 0.8 to 50 g ai ha–1, ARG was suppressed 6% to 76% and 5% to 96%, at 1 and 4 wk after application (WAA), respectively. At 4 WAA, ARG biomass decreased from 29 to 1 g m–2as the rate of nicosulfuron increased from 0.8 to 50 g ai ha–1, compared to 36 g m–2in the untreated control. Where nicosulfuron was not applied to ARG, grain corn yield was reduced by 6% compared to the ARG-free control; similar effects on corn yield were observed with nicosulfuron at the lowest rate applied at 0.8 g ai ha–1. Grain corn yield was reduced by 2.5% with the application of nicosulfuron at 25 g ai ha–1(label rate for corn) compared to no ARG control, but this was not statistically significant. This study identified rates of nicosulfuron that suppressed ARG when emerged approximately the same day as corn, but there was evidence that grain corn yields were lowered because of interference, possibly during the critical weed control period. Based on this study, an ARG cover crop should not be seeded at the same time as corn unless one is willing to accept a risk for corn grain yield losses for the sake of the cover crop.
Off-target Movement of DGA and BAPMA Dicamba to Sensitive Soybean
Authors: Jones Gordon T. , Norsworthy Jason K. , Barber Tom , Gbur Edward , Kruger Greg R. 
Published: March 2019

AbstractIt is well established that dicamba can cause severe injury to soybean that is not resistant to dicamba. Dicamba-resistant (DR) cotton became available in 2015, followed by DR soybean in 2016; in late 2016 came the release of new dicamba formulations approved for topical use in cotton and soybeans. Until this approval, use of dicamba was limited to primarily corn, small grains, range and pasture, and eco-fallow acres. Hence, studies were conducted in 2015 and 2016 to examine off-target movement of two dicamba formulations using non-DR soybean as a bio-indicator. Diglycolamine (DGA) andN,N-Bis(3-aminopropyl)methylamine (BAPMA) dicamba were applied simultaneously at 560 g ae ha–1in the center of two side-by-side 8-ha fields to vegetative glufosinate-resistant soybean. On the same day, a rate response experiment was established encompassing nine different dicamba rates of each formulation. Results from the rate response experiment indicate that soybean is equally sensitive to DGA and BAPMA dicamba. In 2015, a rain event occurring 6 to 8 h after application of the large drift trial probably limited off-target movement by incorporating some of the herbicide into the soil. As a result, secondary drift was less in 2015 than in 2016. However, minimal secondary injury (<5%) occurred 12 m farther into DGA dicamba plots in 2015. In 2016, secondary movement was decreased by 72 m when BAPMA dicamba was used compared to DGA dicamba. Appreciable secondary movement of both DGA and BAPMA dicamba is possible following in-crop applications of either formulated product to soybean in early to mid-summer. Additionally, the risk for secondary movement of BAPMA dicamba is slightly less than for DGA dicamba.
Florpyrauxifen-benzyl activity on perennial grass weeds found in Louisiana rice production
Authors: Teló Gustavo M. , Webster Eric P. , Blouin David C. , McKnight Benjamin M. , Rustom Samer Y. 
Published: March 2019

AbstractA glasshouse study was conducted on the Louisiana State University campus in Baton Rouge, LA, to evaluate the control of brook crowngrass, rice cutgrass, southern watergrass, and water paspalum. Florpyrauxifen-benzyl was applied at 30 g ai ha−1 to each grass species at the 3- to 4-leaf or 1- to 2-stolon stage of growth. Brook crowngrass treated with florpyrauxifen was controlled 71% at 21 d after treatment. Southern watergrass and water paspalum control did not exceed 56% and 36%, respectively, across all evaluations. Rice cutgrass treated with florpyrauxifen did not reach 15% control. Plants treated with florpyrauxifen, except rice cutgrass, displayed reduction in leaf number, stolon number, plant height, and plant fresh weight. These results indicate florpyrauxifen-benzyl can help manage a brook crowngrass infestation and suppress southern watergrass. However, florpyrauxifen-benzyl has little to no activity on water paspalum and rice cutgrass, and other management options should be employed if these weeds are present.
Dual blockage of both PD-L1 and CD47 enhances immunotherapy against circulating tumor cells
Authors: Lian Shu , Xie Ruizhi , Ye Yuying , Lu Yusheng , Cheng Yunlong , Xie Xiaodong , Li Shuhui , Jia Lee 
Published: March 2019

AbstractCarcinoma metastasis is triggered by a subpopulation of circulating tumor cells (CTCs). And single immune checkpoint therapy is not good enough to inhibit CTC-induced metastasis. Here, we demonstrate that simultaneously blocking CD274 (programmed death ligand 1, PD-L1 or B7-H1) and CD47 checkpoints which were respectively signal of “don’t find me” and “don’t eat me” on CTCs by corresponding antibodies could enhance the inhibition tumor growth than single CD274 or CD47 antibody alone.In vitroflow cytometry data proved that CD47 and CD274 were overexpressed on the tested mouse tumor cell lines. The antibodies could effectively block the expressions of CD47 and CD274 on the cell surface and stably attached to tumor cell surface for several hours. The simultaneous blockade on both CD47 and CD274 checkpoints inhibited tumor growth and CTCs metastasis more potently than a single antibody inhibition or blank control on 4T1 tumor mouse modelin vivo. Our results demonstrated that simultaneous dual targeting immune checkpoints, i.e., CD47 and CD274, by using specific antibodies may be more effective as an immunotherapeutics on CTCs than a CD47 or CD274 alone.
Jujuboside A prevents sleep loss-induced disturbance of hippocampal neuronal excitability and memory impairment in young APP/PS1 mice
Authors: Tabassum Sidra , Misrani Afzal , Tang Bin-liang , Chen Jian , Yang Li , Long Cheng 
Published: March 2019

AbstractSleep deprivation (SD) is the hallmark of modern society and may increase risk of Alzheimer’s disease (AD). However, it is unclear how SD facilitates early cognitive impairments observed in AD models, as the underlying molecular mechanism is largely unknown. Here, we aim to investigate SD-induced cellular and molecular alterations in hippocampus of young APP/PS1 mice and whether jujuboside A (JuA) treatment could negate these alterations. Our results reveal that although SD causes spatial memory impairments in both genotypes, SD decreases frequency and amplitude of mEPSCs and pCREB levels in WT, but increases frequency and amplitude of mEPSCs, NMDAR, GluR1, pCaMKII (β, α) and decreases CREB levels in APP/PS1 mice, implicating that SD may facilitate abnormalities in young APP/PS1 mice via enhancing neuronal excitability. Moreover, JuA suppresses SD-induced enhancement of mEPSCs and prevents memory impairment in APP/PS1 mice. Further, whole-cell puff experiment suggests that JuA may function to activate GABAergic inhibition to reduce SD-induced enhancement of excitatory synaptic transmission in APP/PS1 mice. The present study reveals that sleep loss induces spatial memory impairment in an AD mouse model by disrupting the excitatory signaling pathway, and JuA prevents this via GABAergic mechanism.
Oligoclonal immunoglobulin repertoire in biliary remnants of biliary atresia
Authors: Taylor Sarah A. , Malladi Padmini , Pan Xiaomin , Wechsler Joshua B. , Hulse Kathryn E. , Perlman Harris , Whitington Peter F. 
Published: March 2019

AbstractBiliary atresia (BA) is a neonatal cholestatic liver disease that is the leading cause of pediatric liver transplantation, however, the mechanism of disease remains unknown. There are two major forms of BA: isolated BA (iBA) comprises the majority of cases and is thought to result from an aberrant immune response to an environmental trigger, whereas syndromic BA (BASM) has associated malformations and is thought to arise from a congenital insult. To determine whether B cells in BA biliary remnants are antigen driven, we examined the immunoglobulin (Ig) repertoire of diseased tissue from each BA group. Deep sequencing of the Ig chain DNA was performed on iBA and BASM biliary remnants and lymph nodes obtained from the Childhood Liver Disease Research Network (ChiLDReN) repository. Statistical analysis of the Ig repertoire provided measures of Ig clonality and the Ig phenotype. Our data demonstrate that B cells infiltrate diseased iBA and BASM biliary remnant tissue. The Ig repertoires of iBA and BASM disease groups were oligoclonal supporting a role for an antigen-driven immune response in both sub-types. These findings shift the current understanding of BA and suggest a role for antigen stimulation in early iBA and BASM disease pathogenesis.
Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis
Authors: Tan Boyu , Ning Ning 
Published: March 2019

Abstract
Alcohol consumption has been established to be a major factor in the development and progress of cancer. Genetic polymorphisms of alcohol-metabolism genes result in differences between individuals in exposure to acetaldehyde, leading to possible carcinogenic effects. Arg47His (rs1229984 G &gt; A) in ADH1B have been frequently studied for its potential effect on carcinogenesis. However, the findings are as yet inconclusive. To gain a more precise estimate of this potential association, we conducted a meta-analysis including 66 studies from 64 articles with 31999 cases and 50964 controls. The pooled results indicated that ADH1B Arg47His polymorphism is significantly associated with the decreased risk of overall cancer (homozygous model, odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.49–0.77; heterozygous model, OR = 0.71, 95% CI = 0.60–0.84; recessive model, OR = 0.83, 95% CI = 0.76–0.91; dominant model, OR = 0.62, 95% CI = 0.53–0.72; and allele comparison, OR = 0.82, 95% CI = 0.75–0.89). Stratified analysis by cancer type and ethnicity showed that a decreased risk was associated with esophageal cancer and head and neck cancer amongst Asians. In conclusion, our meta-analysis suggested that ADH1B Arg47His polymorphism was significantly associated with decreased overall cancer risk. These findings need further validation in large multicenter investigations.
Study of gravitational fields and globular cluster systems of early-type galaxies
Authors: Bílek M. , Samurović S. , Renaud F. 
Published: March 2019

Context.Gravitational fields at the outskirts of early-type galaxies (ETGs) are difficult to constrain observationally. It thus remains poorly explored how well the ΛCDM and MOND hypotheses agree with ETGs.Aims.The dearth of studies on this topic motivated us to gather a large sample of ETGs and examine homogeneously which dark matter halos they occupy, whether the halos follow the theoretically predicted stellar-to-halo mass relation (SHMR) and the halo mass-concentration relation (HMCR), whether ETGs obey MOND and the radial acceleration relation (RAR) observed for late-type galaxies (LTGs), and finally whether ΛCDM or MOND perform better in ETGs.Methods.We employed Jeans analysis of radial velocities of globular clusters (GCs). We analysed nearly all ETGs having more than about 100 archival GC radial velocity measurements available. The GC systems of our 17 ETGs extend mostly over ten effective radii. A ΛCDM simulation of GC formation helped us to interpret the results.Results.Successful ΛCDM fits are found for all galaxies, but compared to the theoretical HMCR and SHMR, the best-fit halos usually have concentrations that are too low and stellar masses that are too high for their masses. This might be because of tidal stripping of the halos or because ETGs and LTGs occupy different halos. Most galaxies can be fitted by the MOND models successfully as well, but for some of the galaxies, especially those in centers of galaxy clusters, the observed GC velocity dispersions are too high. This might be a manifestation of the additional dark matter that MOND requires in galaxy clusters. Additionally, we find many signs that the GC systems were perturbed by galaxy interactions. Formal statistical criteria prefer the best-fit ΛCDM models over the MOND models, but this might be due to the higher flexibility of the ΛCDM models. The MOND approach can predict the GC velocity dispersion profiles better.
Diuretika-Therapie
Authors: Büttner Stefan , Koch Alexander , Pfeilschifter Josef 
Published: March 2019

AbstractThe treatment of generalized edema includes primarily the treatment of the underlying disease as well as the sodium restriction. Often, however, the volume balance alone can not be controlled satisfactorily. Commonly, diuretics are used for the treatment of chronic heart failure, liver cirrhosis, nephrotic syndrome and renal failure. Diuretics are well documented effective and necessary drugs for the treatment of hypervolemia. From a symptomatic point of view, they are indispensable for cardiac decompensation and they have a firm place in the treatment of hypertension. Due to the different effects as well as pharmacological differences, diuretics can be used for differential therapeutics. The therapy can be associated with side effects. Sequential nephron blockade may be useful in diuretic resistance, but evidence in controlled trials is still lacking. This review provides an overview of the mechanisms, diuretic use and diuretic resistance.
Das kardiorenale Syndrom
Authors: Brandenburg Vincent , Heine Gunnar 
Published: March 2019

AbstractIn patients with chronic cardio renal syndrome chronic heart disease coexists with chronic kidney disease and poses the patients to a specifically high risk for cardiovascular events and mortality. Treatment recommendations in this condition with a high level of evidence are sparse. Mainstay of therapy in cardiorenal syndrome is fluid metabolism control and stabilization of renal and cardiac function, which can basically been achieved by substances modifying the renin-angiotensin-aldosterone-system as well as diuretics. Noteworthy, despite inducing short-term decreases in renal function, inhibition of the RAAS and diuretic medication associate with the long-term improvements of outcome (so-called pseudo-worsening of renal function). The chronic cardiorenal syndrome calls for interdisciplinary care by both nephrologists and cardiologists in order to allow high-end patient care with a maximum of beneficial effect and a minimum of treatment-related side effects.
Intensity Matters: High-intensity Interval Exercise Enhances Motor Cortex Plasticity More Than Moderate Exercise
Authors: Andrews Sophie C , Curtin Dylan , Hawi Ziarih , Wongtrakun Jaeger , Stout Julie C , Coxon James P 
Published: March 2019

AbstractA single bout of cardiovascular exercise can enhance plasticity in human cortex; however, the intensity required for optimal enhancement is debated. We investigated the effect of exercise intensity on motor cortex synaptic plasticity, using transcranial magnetic stimulation. Twenty healthy adults (Mage = 35.10 ± 13.25 years) completed three sessions. Measures of cortico-motor excitability (CME) and inhibition were obtained before and after a 20-min bout of either high-intensity interval exercise, moderate-intensity continuous exercise, or rest, and again after intermittent theta burst stimulation (iTBS). Results showed that high-intensity interval exercise enhanced iTBS plasticity more than rest, evidenced by increased CME and intracortical facilitation, and reduced intracortical inhibition. In comparison, the effect of moderate-intensity exercise was intermediate between high-intensity exercise and rest. Importantly, analysis of each participant’s plasticity response profile indicated that high-intensity exercise increased the likelihood of a facilitatory response to iTBS. We also established that the brain-derived neurotrophic factor Val66Met polymorphism attenuated plasticity responses following high-intensity exercise. These findings suggest that high-intensity interval exercise should be considered not only when planning exercise interventions designed to enhance neuroplasticity, but also to maximize the therapeutic potential of non-invasive brain stimulation. Additionally, genetic profiling may enhance efficacy of exercise interventions for brain health.
One-year cost-effectiveness and safety of simultaneous hybrid coronary revascularization versus conventional coronary artery bypass grafting
Authors: Rimestad Jesper Møller , Christiansen Evald Høj , Modrau Ivy Susanne 
Published: March 2019

Abstract

OBJECTIVES
To evaluate the cost-effectiveness and safety of simultaneous hybrid coronary revascularization (sHCR) compared to conventional coronary artery bypass grafting (CABG) in elective patients with multivessel coronary artery disease.

METHODS
Cost–utility analysis of a prospective cohort follow-up study comparing per protocol 50 sHCR patients to 50 contemporaneous matched patients undergoing CABG. Resource utilization data and health-related quality of life were collected prospectively, and the cumulative 1-year costs were assessed from the Danish health sector perspective. Effectiveness was measured by quality-adjusted life years using EuroQol-5D. Probabilistic sensitivity analyses using bootstrapping were conducted. Secondary safety measures including early clinical outcomes and freedom from major adverse cardiac or cerebrovascular events at 1 year were assessed.

RESULTS
The clinical trial was discontinued prematurely due to safety reasons after inclusion of 50 patients (24 sHCR; 26 CABG), as the chest tube output and the risk of postoperative pleural effusions requiring thoracocentesis were significantly increased following sHCR compared with CABG. Based on 48 patients available for 1-year follow-up, both treatment strategies were similarly effective (quality-adjusted life year difference between the groups −0.019), with a net cost difference in favour of conventional CABG estimated to be €2173 per patient. Exclusion of 1 outlier patient with chronic renal failure and deep sternal wound infection in the sHCR group resulted in an equalization of the total 1-year costs.

CONCLUSIONS
At 1 year, sHCR was less cost-effective than conventional CABG and associated with higher chest tube output and a higher risk of postoperative pleural effusions requiring thoracocentesis.

Clinical trial registration
NCT01496664.
Cognitive Function in Pediatric Hypoplastic Left Heart Syndrome: Systematic Review and Meta-Analysis
Authors: Siciliano Rachel E , Prussien Kemar V , Lee Chelsea A , Patel Niral J , Murphy Lexa K , Compas Bruce E , Jordan Lori C 
Published: March 2019

AbstractObjectiveDespite surgical palliation, children with hypoplastic left heart syndrome (HLHS) have compromised cardiac functioning and increased risk for cognitive deficits. We quantitatively reviewed the empirical data from this literature.MethodsThe present meta-analysis included 13 studies reporting cognitive function for children with HLHS between the ages of 2 years and 6 months and 17 years that used standardized assessments of Full Scale IQ (FSIQ), Verbal IQ (VIQ), and Performance IQ (PIQ). Differences in cognitive function were assessed relative to normative data, and we examined sample mean age and publication year as moderators.ResultsLarge effects were found for FSIQ (g = −.87, 95% CI [−1.10, −.65], M = 86.88) and PIQ (g = −.89, 95% CI [−1.11, −.68], M = 86.56), and a medium effect was found for VIQ (g = −.61, 95% CI [−.84, −.38], M = 90.82). All models demonstrated significant heterogeneity. Meta-regression analyses of effect size via Hedges’ g on child age revealed a significant effect on FSIQ (coefficient = −.07, 95% CI [−.12, −.01], p < .01, R2 = .40) indicating a loss of 1.1 FSIQ points across studies with each increased year of mean sample age.ConclusionsDeficits in FSIQ may reflect chronic brain injury or failure to make expected gains as children age. This review highlights the importance of early intervention in this population, and the need for longitudinal studies analyzing more specific domains of cognitive function and potential moderators.
The Impact of the Global Financial Crisis on Central Banking
Authors: Cukierman Alex 
Published: March 2019

Abstract
This chapter describes the impacts of the global financial crisis on monetary policy and institutions. It argues that during the crisis, financial stability took precedence over traditional inflation targeting and discusses the emergence of unconventional policy instruments such as quantitative easing (QE), forex market interventions, negative interest rates, and forward guidance. It describes the interaction between the zero lower bound (ZLB) and QE, and proposals, such as raising the inflation target, to alleviate the ZLB constraint. The chapter discusses the consequences of the relative passivity of fiscal policies, “helicopter money,” and 100 percent reserve requirement. The crisis triggered regulatory reforms in which central banks’ objectives were expanded to encompass macroprudential regulation. The chapter evaluates recent regulatory reforms in the United States, the euro area, and the United Kingdom. It presents data on new net credit formation during the crisis and discusses implications for exit policies.
Neuroimmune Interactions and Pain
Authors: Li Jiahe , Grace Peter M. 
Published: March 2019

Abstract
Chronic pain imposes a tremendous burden on the sufferer’s quality of life. Mounting evidence supports a critical role for neuroimmune interactions in the development and maintenance of chronic pain. Nerve injury leads to the activation of glia via sphingosine-1-phosphate, Toll-like receptors, chemokines, neuropeptides, and purinergic receptors. In turn, activated glia influence neuronal activity via interleukin 1β, tumor necrosis factor, brain-derived neurotrophic factor, reactive oxygen species, and excitatory amino acids. Epigenetic mechanisms of neuroimmune communication are also discussed. Investigation of neuroimmune interactions after peripheral nerve injury broadens our understanding of the mechanisms that drive neuropathic pain, and such interactions provide potential therapeutic targets for managing neuropathic pain.