bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guaranteed cost control of distributed parameter networked control systems with time‐varying delay
Authors: Zhu Qixin , Lu Kaihong , Zhu Yonghong 
Published: December 2018

AbstractDistributed parameter networked control systems mean distributed parameter systems are controlled through a network, where the control loops are closed. In this paper, the problem of guaranteed cost and state feedback controller design is investigated for a class of distributed parameter networked control systems. With the network factors, such as transmission delays, data packet dropouts considered, the distributed parameter networked control system is modeled as a linear closed‐loop system with time‐varying delay and uncertain parameters. By selecting an appropriate Lyapunov‐Krasovskii function and using linear matrix inequality (LMI) approach, the controller is designed to render the system stable and it can keep the cost function less than a certain upper value. In addition, numerical simulation is included to demonstrate the theoretical results.
Validation of the Bluebelle Wound Healing Questionnaire for assessment of surgical-site infection in closed primary wounds after hospital discharge
Authors:   Bluebelle Study Group, Macefield Rhiannon , Blazeby Jane , Reeves Barnaby , Brookes Sara , Avery Kerry , Rogers Chris , Woodward Mark , Welton Nicky , Rooshenas Leila , Mathers Jonathan , Torrance Andrew , Pullyblank Anne , Longman Robert , Lovegrove Richard , Draycott Tim , Pinkney Thomas , Gooberman-Hill Rachael , Donovan Jenny , Coast Joanna , Calvert Melanie , Blencowe Natalie , Andronis Lazaros , Siassakos Dimitrios , Pope Caroline , Clout Madeleine , Ashton Kate , Ellis Lucy , McMullan Christel , Harris Rosie , Elliott Daisy , Dumville Jo , Waterhouse Benjamin , Strong Sean , Seligman William , Rickard Lloyd , Pathak Samir , Owais Anwar , O'Callaghan Jamie , O'Brien Stephen , Nepogodiev Dmitri , Nadi Khaldoun , Murkin Charlotte , Munder Tonia , Milne Tom , Messenger David , Mason Matthew , Marshall Morwena , Lloyd Jessica , Lim Jeffrey , Lee Kathryn , Korwar Vijay , Hughes Daniel , Hill George , Hamdan Mohammed , Brown Hannah Gould , Glasbey James , Fryer Caroline , Davey Simon , Cotton David , Byrne Benjamin , Brown Oliver , Bera Katarzyna , Bennett Joanne , Bamfor Richard , Bakhbakhi Danya , Atif Muhammad , Armstrong Elizabeth , Ananthavarathan Piriyankan 
Published: December 2018

Abstract

Background
Accurate assessment of surgical-site infection (SSI) is crucial for surveillance and research. Self-reporting patient measures are needed because current SSI tools are limited for assessing patients after leaving hospital. The Bluebelle Wound Healing Questionnaire (WHQ) was developed for patient or observer completion; this study tested its acceptability, scale structure, reliability and validity in patients with closed primary wounds after abdominal surgery.

Methods
Patients completed the WHQ (self-assessment) within 30 days after leaving hospital and returned it by post. Healthcare professionals completed the WHQ (observer assessment) by telephone or face-to-face. Questionnaire response rates and patient acceptability were assessed. Factor analysis and Cronbach's α examined scale structure and internal consistency. Test–retest and self- versus observer reliability assessments were performed. Sensitivity and specificity for SSI discrimination against a face-to-face reference diagnosis (using Centers for Disease Control and Prevention criteria) were examined.

Results
Some 561 of 792 self-assessments (70·8 per cent) and 597 of 791 observer assessments (75·5 per cent) were completed, with few missing data or problems reported. Data supported a single-scale structure with strong internal consistency (α greater than 0·8). Reliability between test–retest and self- versus observer assessments was good (κ 0·6 or above for the majority of items). Sensitivity and specificity for SSI discrimination was high (area under the receiver operating characteristic (ROC) curve 0·91).

Conclusion
The Bluebelle WHQ is acceptable, reliable and valid with a single-scale structure for postdischarge patient or observer assessment of SSI in closed primary wounds.
HPTLC Autography Based Screening and Isolation of Mushroom Tyrosinase Inhibitors of European Plant Species
Authors: Revoltella Silvia , Rainer Bettina , Waltenberger Birgit , Pagitz Konrad , Schwaiger Stefan , Stuppner Hermann 
Published: December 2018

AbstractIn the course of this project, 133 plants were evaluated on their ability to inhibit tyrosinase, a key enzyme in melanogenesis. The screening was performed by means of a HPTLC autographic assay, resulting in the selection of three plants, Asplenium trichomanes, Pinus uncinata, and Scutellaria altissima, with promising tyrosinase inhibiting activities. With the aid of the HPTLC assay, it was not only possible to select the most interesting plant extracts, but also to monitor the activity‐guided fractionation which, in a relatively short time period, led to the isolation of active principles. Benzoic acid, roseoside, and dihydrovomifoliol‐O‐β‐d‐glucopyranoside could be identified as tyrosinase inhibitors present in P. uncinata. Globularin turned out to be the active principle of S. altissima, and 4‐ethenylphenyl 6‐O‐(6‐deoxy‐α‐l‐mannopyranosyl)‐β‐d‐glucopyranoside was detected as tyrosinase inhibitor of A. trichomanes. The pure compounds were tested also in a 96 well‐plate assay in order to determine their IC50 values. The lowest IC50 value (42 μm) could be obtained for globularin, whereas the other compounds, e. g., benzoic acid exhibited a rather high IC50 value (IC50=552 μm). This stood in clear contrast to the autographic assay, but is has to be taken into account that the outcome of the autography assay is not only depending on the IC50 value of a compound, but also on the content of the respective constituent in the extract.
Study on the Materials Formed by Self‐Assembling Hydrophobic, Aromatic Peptides Dedicated to Be Used for Regenerative Medicine
Authors: Chaberska Agata , Fraczyk Justyna , Wasko Joanna , Rosiak Piotr , Kaminski Zbigniew J. , Solecka Agnieszka , Stodolak‐Zych Ewa , Strzempek Weronika , Menaszek Elzbieta , Dudek Mariusz , Niemiec Wiktor , Kolesinska Beata 
Published: December 2018

AbstractThe aims of this study were to identify the short aromatic peptides which are able to form highly ordered amyloid‐like structures in self‐assembling processes, to test the influence of length of hydrophobic peptides on tendency to aggregation, and to check if aggregated peptides fulfill requirements expected for materials useful for scaffolding. All tested hydrophobic peptides were prepared on solid phase by using DMT/NMM/TsO− as a coupling reagent. The progress of aggregation was studied by set of independent tests. All aggregated peptides were found stable under in vitro conditions. All fibrous material formed by self‐assembling of peptides does not show any cytotoxic effects on L929 fibroblast cells. Peptides containing tyrosine and tryptophan residues even effectively accelerated the proliferation and stimulated the activity of L929 fibroblasts.
Ecological Roles of Tryptanthrin, Indirubin and N‐Formylanthranilic Acid in Isatis indigotica: Phytoalexins or Phytoanticipins?
Authors: Pedras M. Soledade C. , Abdoli Abbas , To Q. Huy , Thapa Chintamani 
Published: December 2018

AbstractLeaves of the plant species Isatis indigotica Fortune ex Lindl. (Chinese woad) produce the metabolites tryptanthrin, indirubin and N‐formylanthranilic acid upon spraying with an aqueous solution of copper chloride but not after spraying with water. The antifungal activities of these metabolites against the phytopathogens Alternaria brassicicola, Leptosphaeria maculans and Sclerotinia sclerotiorum established that tryptanthrin is a much stronger growth inhibitor of L. maculans than the phytoalexin camalexin. The biosynthetic precursors of tryptanthrin and N‐formylanthranilic acid are proposed based on the deuterium incorporations of isotopically labeled compounds. The overall results suggest that tryptanthrin is a phytoalexin and indirubin and N‐formylanthranilic acid are phytoanticipins in the plant species I. indigotica and that chemical diversity and biodiversity are intimately connected.
GPU R‐Trie: Dictionary with ultra fast lookup
Authors: Kaczmarski Krzysztof , Wolant Albert 
Published: December 2018

SummaryR‐Trie dictionary is a multi‐way retrieval tree for arbitrary length binary keys. It is designed taking into account utilization of thousands of parallel vector threads, a fundamental technique of programming GPU processors. Dictionary bulk creation algorithm automatically scales to use as many threads as elements in the input batch, without any synchronization or page locking, exceeding 20·106 key insertions per second on a consumer class device. Bulk search procedure achieves 600·106 lookups per second in case of a Longest Prefix Match algorithm and 3·109 lookups per second in case of exact key matching. In this paper, we describe details of implementation, present results of run‐time experiments, and enumerate several open problems for future.
Quality assessment of Ki67 staining using cell line proliferation index and stain intensity features
Authors: Lanng Mathias Buus , Møller Cecilie Brochdorff , Andersen Anne‐Sofie Hendrup , Pálsdóttir Ásgerður Arna , Røge Rasmus , Østergaard Lasse Riis , Jørgensen Alex Skovsbo 
Published: December 2018

AbstractBreast cancer is the most frequent cancer among women worldwide. Ki67 can be used as an immunohistochemical pseudo marker for cell proliferation to determine how aggressive the cancer is and thereby the treatment of the patient. No standard Ki67 staining protocol exists, resulting in inter‐laboratory stain variability. Therefore, it is important to determine the quality control of a staining protocol to ensure correct diagnosis and treatment of patients. Currently, quality control is performed by the organization NordiQC that use an expert panel‐based qualitative assessment system. However, no objective method exists to determine the quality of a staining protocol. In this study, we propose an algorithm, to objectively assess staining quality from segmented cell nuclei structures extracted from cell lines. The cell nuclei were classified into either Ki67 positive or negative to determine the Ki67 proliferation index within the cell lines. A Ki67 stain quality model based on ordinal logistic regression was developed to determine the quality of a staining protocol from features extracted from the segmented cell nuclei in the cell lines. The algorithm was able to segment and classify Ki67 positive cell nuclei with a sensitivity and positive predictive value (PPV) of 0.90 and 0.94 and Ki67 negative cell nuclei with a sensitivity and PPV of 0.78 and 0.78. The mean difference between a manual and automatic Ki67 proliferation index was −0.003 with a standard deviation of 0.056. The ordinal logistic regression model found that the stain intensity for both the Ki67 positive and Ki67 negative cell nuclei were statistically significant as parameters determining the stain quality from the cell line cores. The framework shows great promise for using cell nuclei information from cell lines to predict the staining quality of staining protocols. © 2018 International Society for Advancement of Cytometry
Infrastructure‐based vehicular congestion detection scheme for V2I
Authors: Ahmad Mushtaq , Chen Qingchun , Khan Zahid , Ahmad Muqeet , Khurshid Faisal 
Published: December 2018

SummaryWith the increasing number of vehicles, traffic jam becomes one of the major problems of the fast‐growing world. Intelligent transportation system (ITS) communicates perilous warnings and information on forthcoming traffic jams to all vehicles within its coverage region. Real‐time traffic information is the prerequisite for ITS applications development. In this paper, on the basis of the vehicle‐to‐infrastructure (V2I) communication, a novel infrastructure‐based vehicular congestion detection (IVCD) scheme is proposed to support vehicular congestion detection and speed estimation. The proposed IVCD derives the safety time (time headway) between vehicles by using iterative content‐oriented communication (COC) contents. Meanwhile, the roadside sensor (RSS) provides an infrastructure framework to integrate macroscopic traffic properties into the estimation of both the traffic congestion and vehicle safety speed. The main responsibilities of RSS in IVCD are to preserve privacy, aggregate data, store information, broadcast routing table, estimate safety speed, detect traffic jam, and generate session ID (S‐ID) for vehicles. Monte Carlo simulations in four typical Chinese highway settings are presented to show the advantage of the proposed IVCD scheme over the existing Greenshield's and Greenberg's macroscopic congestion detection schemes in terms of the realized congestion detection performance. Real road traces generated by Simulation of Urban Mobility (SUMO) over NS‐3.29 are utilized to demonstrate that the proposed IVCD scheme is capable of effectively controlling congestion in both single and multilane roads in terms of density and speed health with previous schemes in this field.
Designing nanoporosity in a swollen polymer for the controlled release of a highly volatile fragrance
Authors: Chen Xinwei , Bhardwaj Ankit , Sharifah Nursyahirah Syed Isha , Zhang Liling , Man Shu Mei , Andriani Yosephine , Tan Wui Siew 
Published: December 2018

AbstractControlling the fragrance release profile, especially the highly volatile top note, can prolong the desired scent of the fragrance. Here, the porosity of a swollen cross‐linked polyurethane acrylate (PUA) polymer, which is tuned by the length of a modulator, can influence the evaporation rate of the top note. In particular, the evaporation rate of benzyl acetate (BA), a common top note, is reduced by a factor of 6.5 (from 134 to 17 mg m–2 min–1) when BA is released from the best‐performing PUA against a reservoir of BA. The average diameter of an opening in the fragrance‐loaded PUA is ~6 nm, as determined by the thermoporosimetry approach. Such a pore size can effectively control the evaporation rate of BA, as predicted by the theoretical model, which reveals that a pore diameter of <16 nm is required. Computational modelling reveals the optimal chain length for a modulator used for the sustained released of fragrance, confirming the experimental data. Finally, BA continues to be released from the PUA matrix for a prolonged period, even after 3 months, whereas the same quantity of BA would completely evaporate after 1 week in the absence of PUA matrix. Approximately 50wt% of BA remains after 60 days, making it one of the best techniques in sustaining the release of a top note.
Finding fault: Criticism as a care management strategy and its impact on outcomes for dementia caregivers
Authors: Leggett Amanda N. , Kales Helen C. , Gitlin Laura N. 
Published: December 2018

BackgroundDespite a large literature on the stress process, little attention has focused on how caregivers for persons living with dementia (PLWDs) provide care and how this may impact care outcomes. Criticism is a management strategy caregivers may use to respond to behavioral symptoms. We consider whether criticism is associated with caregivers' mental health and service utilization.MethodsData are drawn from the Advancing Caregiver Training intervention study including 256 informal caregivers living with a PLWD. In multiple linear regressions controlling for caregivers' demographics and PLWDs' clinical factors, we consider criticism (criticism subscale of the Dementia Management Strategies Scale) as a predictor of caregiver burden, depressive symptoms, desire to institutionalize the PLWD, level of frustration with care, and the number of home‐based, social, and health services utilized.ResultsOn average, 15% of the sample sometimes reported using criticism as a management strategy to manage the challenges of care. Greater use of criticism was associated with significantly more caregiver burden (β = 0.26, P < 0.001) and frustration with caregiving (β = 0.66, P < 0.001), but not depressive symptoms or a desire to institutionalize the PLWD. Criticism was also associated with significantly greater utilization of home‐based (β = 0.14, P < 0.05) and social services (β = 0.15, P < 0.05), but not health care services.ConclusionCriticism appears to be used by more burdened and frustrated caregivers. The association of criticism with social and home‐based services potentially reflects a need for greater support among this group of caregivers. Behavioral interventions that can help caregivers manage behavioral symptoms with positive, empirically validated strategies may be helpful.
Nutrient biomarkers shape individual differences in functional brain connectivity: Evidence from omega‐3 PUFAs
Authors: Talukdar Tanveer , Zamroziewicz Marta K. , Zwilling Christopher E. , Barbey Aron K. 
Published: December 2018

AbstractA wealth of neuroscience evidence demonstrates that diet and nutrition play an important role in structural brain plasticity, promoting the development of gray matter volume and maintenance of white matter integrity across the lifespan. However, the role of nutrition in shaping individual differences in the functional brain connectome remains to be well established. We therefore investigated whether nutrient biomarkers known to have beneficial effects on brain structure (i.e., the omega‐3 polyunsaturated fatty acids; ω‐3 PUFAs), explain individual differences in functional brain connectivity within healthy older adults (N = 96). Our findings demonstrate that ω‐3 PUFAs are associated with individual differences in functional connectivity within regions that support executive function (prefrontal cortex), memory (hippocampus), and emotion (amygdala), and provide key evidence that the influence of these regions on global network connectivity reliably predict general, fluid, and crystallized intelligence. The observed findings not only elucidate the role of ω‐3 PUFAs in functional brain plasticity and intelligence, but also motivate future studies to examine their impact on psychological health, aging, and disease.
A green and mild procedure to selective synthesis of diarylamine via domino reaction of aryl halides and arginine catalyzed by magnetic‐MOF
Authors: Soleiman‐Beigi Mohammad , Mohammadi Fariba 
Published: December 2018

AbstractEfficient and selective direct synthesis of diarylamines from aryl halides and arginine as a nitrogen‐donor reagent is reported. Arginine, which is an oral supplement, acts as a useful nitrogen source donor in the copper‐catalyzed reaction. Fe3O4/Cu3(BTC)2, which was easily separated and recycled with a magnet, improved the rate and facilitation of the synthesis of diarylamines selectively. The introduction of a new and available N‐source, simple magnetic separation process, normal atmospheric conditions, and excellent yields under mild reaction conditions are other important features of this work.
“Five‐point eight‐line” anatomic flap design for precise hemitongue reconstruction
Authors: Fan Song , Li Qun‐Xing , Zhang Han‐Qing , Liang Mao‐Jin , Tian Tian , Wang You‐Yuan , Lin Zhao‐Yu , Chen Wei‐Xiong , Pan Guo‐Kai , Ahn Michael Ho‐Young , He Lile , Sun Sheng , Wu Bing‐Hao , Yu Peirong , Li Jin‐Song 
Published: December 2018

AbstractBackgroundReconstruction of hemiglossectomy defects requires careful flap design to avoid adverse functional and aesthetic outcomes.MethodsHemitongue specimens were obtained from minipigs to study the three‐dimensional anatomy and to define anatomic landmarks for precise measurements of flap requirement. The concept developed in animal models was then applied to hemiglossectomy reconstruction in clinical practice. Sixty‐one patients were randomly enrolled into the following two groups: a “five‐point eight‐line segment” (FIPELS) flap design group (28 patients) and a conventional group (33 patients). Functional and aesthetic outcomes were compared between the two groups.ResultsAll flaps designed with the FIPELS technique matched the hemiglossectomy defects without the need for flap trimming, thus reducing the operating time (P = .03). Swallowing functions, speech intelligibility, and aesthetic outcomes were superior in the FIPELS group than that in the conventional group (P < .05).ConclusionsThe FIPELS flap design for hemiglossectomy reconstruction yields improved functional and aesthetic outcomes compared to a conventional flap design.
Polysaccharide Based Nanoparticles
Authors: Khan Wahid , Abtew Ester , Modani Sheela , Domb Abraham J. 
Published: December 2018

AbstractNanoparticles made of biodegradable polymers have outstanding merits as a drug delivery system. Polysaccharide‐based nanoparticles have been well explored because of their safety, stability, biocompatibility, biodegradability and hydrophilicity. The present review emphasizes the efforts articulated to improve polysaccharide‐based nanoparticles as drug delivery tool for effective therapy and site‐specific targeting of mainly anticancer agents. This review updates reports of recent research on polysaccharides‐based systems particularly chitosan, alginate, cyclodextrins, hyaluronic acid, pullulan, dextran and their combinations with potential applications.
ACVR1‐knockout promotes osteogenic differentiation by activating the Wnt signaling pathway in mice
Authors: Wang Yuan , Sun Jing‐Chuan , Wang Hai‐Bo , Xu Xi‐Ming , Kong Qing‐Jie , Wang Ying‐Jie , Zheng Bing , Shi Guo‐Dong , Shi Jian‐Gang 
Published: December 2018

AbstractOsteogenic differentiation refers to the process of bone formation and remodeling, which is controlled by complex molecular mechanisms. Activin A receptor type I (ACVR1) is reported to be associated with osteogenic differentiation. However, the underlying molecular mechanism remains elusive. Therefore, this study evaluates the function of ACVR1 in osteogenic differentiation through the Wnt signaling pathway. The expression of osteocalcin (Oc) and osterix together with osteogenic differentiation and mineralization was examined in ACVR1‐knockout (KO) mouse. Furthermore, the Wnt signaling pathway was inhibited in bone marrow stromal cells (BMSCs) of mice to explore the role of the Wnt signaling pathway in osteogenic differentiation by means of alkaline phosphatase (ALP) activity detection and evaluation of mineralized nodules and calcium content. Subsequently, the effect of ACVR1 on the Wnt signaling pathway was assessed by determining the expression of ACVR1, β‐catenin, glycogen synthase kinase 3 β (GSK3β), dickkopf‐related protein 1 (DKK1), and frizzled class receptor 1 (FZD1). Both their effects on osteogenic differentiation were further evaluated by determination of Oc, osterix, and Runx2 expression. AVCR1 KO mice exhibited increased Oc and osterix expression and promoted bone resorption and formation. ACVR1‐knockout was observed to activate the Wnt signaling pathway with an increase of β‐catenin and reductions in GSK3β, DKK1, and FZD1. With the inhibited Wnt signaling pathway expression of Oc, osterix, and Runx2 was decreased, and ALP activity, mineralized nodule, and calcium content in cellular matrix were decreased as well, indicating that inactivation of the Wnt signaling pathway reduced the differentiation of BMSCs into osteoclasts. These findings indicate that ACVR1‐knockout promotes osteogenic differentiation by activating the Wnt signaling pathway in mice.