bluuebunny/crossref_metadata_2025_split huggingface dataset:
A diallel of the mouse Collaborative Cross founders reveals strong strain-specific maternal effects on litter size
Authors: Shorter John R. , Maurizio Paul L. , Bell Timothy A. , Shaw Ginger D. , Miller Darla R. , Gooch Terry J. , Spence Jason S. , McMillan Leonard , Valdar William , Pardo-Manuel de Villena Fernando 
Published: October 2018

ABSTRACTReproductive success in the eight founder strains of the Collaborative Cross (CC) was measured using a diallel-mating scheme. Over a 48-month period we generated 4,448 litters, and 24,782 weaned pups were used across 16 different published experiments. We identified factors that affect the average litter size in a cross by estimating the overall contribution of parent-of-origin, heterosis, inbred, and epistatic effects using a Bayesian zero-truncated overdispersed Poisson mixed model. The phenotypic variance of litter size has a substantial contribution (79%) from unexplained and environmental sources, but no detectable effect of seasonality. Most of the explained variance was due to additive effects (9.2%) and parental sex (maternal vs paternal strain; 5.8%), with epistasis accounting for 3.4%. Within the parental effects, the effect of the dam’s strain explained more than the sire’s strain (13.2% vs. 1.8%), and the dam’s strain effects account for 74.2% of total variation explained. Dams from strains C57BL/6J and NOD/ShiLtJ increased the expected litter size by a mean of 1.66 and 1.79 pups, whereas dams from strains WSB/EiJ, PWK/PhJ, and CAST/EiJ reduced expected litter size by a mean of 1.51, 0.81, and 0.90 pups. Finally, there was no strong evidence for strain-specific effects on sex ratio distortion. Overall, these results demonstrate that strains vary substantially in their reproductive ability depending on their genetic background and that litter size is largely determined by dam.strain rather than sire.strain effects, as expected. This analysis adds to our understanding of factors that influence litter size in mammals, and also helps to explain breeding successes and failures in the extinct lines and surviving CC strains.
Dynamic changes in cerebral and peripheral markers of glutamatergic signaling across the human sleep-wake cycle
Authors: Weigend Susanne , Holst Sebastian C. , Treyer Valérie , O’Gorman Tuura Ruth L. , Meier Josefine , Ametamey Simon M. , Buck Alfred , Landolt Hans-Peter 
Published: October 2018

AbstractBoth sleep and glutamatergic signaling in the brain are tightly controlled and homeostatically regulated. Sleep homeostasis is reliably reflected by predictable changes in brain electrical activity in waking and sleep, yet the underlying molecular mechanisms remain elusive. Current hypotheses posit that recovery sleep following prolonged waking restores efficient functioning of the brain, for example by keeping glutamatergic signaling in a homeostatic range. We recently provided evidence in humans and mice that metabotropic glutamate receptors of subtype-5 (mGluR5) contribute to the brain’s coping mechanisms with sleep deprivation. Here we combined in 31 healthy men, proton magnetic resonance spectroscopy to measure the levels of glutamate (Glu), GLX (glutamate-to-glutamine ratio) and GABA (γ-amino-butyric-acid) in basal ganglia (BG) and dorsolateral prefrontal cortex, simultaneous positron emission tomography to quantify mGluR5 availability with the novel radioligand, [18F]PSS232, and quantification in blood plasma of the mGluR5-regulated proteins, fragile-X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF). All measurements were conducted at the same circadian time in baseline, following sleep deprivation and after recovery sleep. We found that Glu and GLX in BG (pall < 0.01), but not in prefrontal cortex, and the plasma concentration of FMRP (p < 0.02), were increased after sleep loss and tended to normalize following recovery sleep (pall < 0.1). Furthermore, a night without sleep enhanced whole-brain and striatal mGluR5 availability and was normalized by recovery sleep (pall < 0.05). By contrast, other brain metabolites and plasma BDNF levels were not altered. The findings demonstrate convergent changes in distinct markers of glutamatergic signaling across prolonged wakefulness and recovery sleep in humans. They warrant further studies to elucidate the underlying mechanisms that link the homeostatic regulation of sleep and glutamatergic system activity in health and disease.One-sentence summarySleep-dependent recovery of wakefulness-induced changes in, cerebral glutamatergic signalingMajor subject areaNeuroscience; Human Biology & Medicine
Reducing the thermal influence of a bleed pipe near a composite fuel tank wall
Authors: Moghadasi S. Marie , de Wit Albert J. , Chiacchio Fabio 
Published: October 2018

Purpose
The purpose of this paper is to determine thermal behaviour of wing fuel tank wall via heating by external heat sources.

Design/methodology/approach
A 3D finite element model of the structure has been created that takes into account convection, conduction and radiation effects. In addition, a 3D finite volume model of the air inside the leading edge is created. Through a computational fluid dynamics approach, the flow of air and thermal behaviour of the air is modelled. The structure and fluid model are coupled via a co-simulation engine to exchange heat flux and temperature. Different ventilation cases of the leading edge and their impact on the thermal behaviour of the tank wall (corresponding to the front spar) are investigated.

Findings
Results of 3D analysis illustrate good insight into the thermal behaviour of the tank wall. Furthermore, if regions exist in the leading edge that differs significantly from the overall thermal picture of the leading edge, these are visible in a 3D analysis. Finally, the models can be used to support a flammability analysis assessment.

Practical implications
Provided that the bleed pipe is located far enough from the spar and covered with sufficient thermal heat isolation, the composite leading edge structure will not reach extremely high temperatures.

Originality/value
These detailed simulations provide accurate results which can be used as reliable input for the fuel tank flammability analysis.
Composite technology development based on helicopter rotor blades
Authors: Kozaczuk Konrad Jerzy 
Published: October 2018

Purpose
This paper aims to document the approach, effort and cost of advance composite technology implementation suited for small and medium enterprises on the example of composite main rotor blade development for ILX-27 helicopter.

Design/methodology/approach
This work was carried out as part of a development project for main rotor blades used on the ILX 27 helicopter. The paper presents all stages of the design of the blade structure in parallel with composite technology development. The data were gathered and documented during project execution. The stages of R&D work in terms of labor intensity and important processes influencing quality and efficiency were assessed.

Findings
The paper provides key aspects for successful composite capability introduction. The incurred cost of equipment and staff training is evaluated. The paper also summarized the cost of composite parts manufactured with developed technology.

Practical implications
The paper provides detail example of composite capability development including basic technologies, processes, equipment and cost of the project. Presented details can be great guidelines for small and medium enterprises with the goal of composite technology introduction for aerostructures design and manufacturing.

Originality/value
This paper present clear, complete and verified process of composite capability development for aerostructures design and build suited for small and medium enterprises. It presents detail cost, calculated in Polish economy environment, of each phase and final cost of the product.
Design of a double parabolic supersonic nozzle and performance evaluation by experimental and numerical methods
Authors: A.K. Mubarak , P.S. Tide 
Published: October 2018

Purpose
The purpose of this paper is to design a double parabolic nozzle and to compare the performance with conventional nozzle designs.

Design/methodology/approach
The throat diameter and divergent length for Conical, Bell and Double Parabolic nozzles were kept same for the sake of comparison. The double parabolic nozzle has been designed in such a way that the maximum slope of the divergent curve is taken as one-third of the Prandtl Meyer (PM) angle. The studies were carried out at Nozzle Pressure Ratio (NPR) of 5 and also at design conditions (NPR = 3.7). Experimental measurements were carried out for all the three nozzle configurations and the performance parameters compared. Numerical simulations were also carried out in a two-dimensional computational domain incorporating density-based solver with RANS equations and SST k-ω turbulence model.

Findings
The numerical predictions were found to be in reasonable agreement with the measured experimental values. An enhancement in thrust was observed for double parabolic nozzle when compared with that of conical and bell nozzles.

Research limitations/implications
Even though the present numerical simulations were capable of predicting shock cell parameters reasonably well, shock oscillations were not captured.

Practical implications
The double parabolic nozzle design has enormous practical importance as a small increase in thrust can result in a significant gain in pay load.

Social implications
The thrust developed by the double parabolic nozzle is seen to be on the higher side than that of conventional nozzles with better fuel economy.

Originality/value
The overall performance of the double parabolic nozzle is better than conical and bell nozzles for the same throat diameter and length.
Challenges of cultivating critical citizens in Hong Kong
Authors: Kin Cheung Adrian Yan 
Published: October 2018

PurposeThe purpose of this paper is to offer the latest empirical findings of the difficulties and challenges in teaching New Senior Secondary (NSS) Liberal Studies in Hong Kong from the perspective of pre-service teachers.Design/methodology/approachThis qualitative study is based on Danielewicz’s critical pedagogy framework for identity development. A sample of four pre-service teachers were recruited from the last cohort of final-year bachelor of education students at the University of Hong Kong. They were invited to engage in dialogues of enquiry, through which they recount their teaching encounters during their teaching practices. Emphasis would be put on two relevant pedagogical principles, including deliberation and reflexivity, which are of particular relevance to the case of Liberal Studies.FindingsChallenges revealed the dispositions of conformist learning among the students, manifested in forms of misquoted information and the populist sentiments mirrored from mainstream media, which cost teachers extra efforts to facilitate inquiry-based learning. Adopting deliberation and reflexivity as pedagogical principles, student–teachers responded with attempts to reconnect daily life experiences to teaching, bringing back the social context of knowledge and seeking synergy between traditional and liberatory teaching methods.Research limitations/implicationsThis study is drawn from a relatively small sample of pre-service teachers and may run the risk of over-generalization. Moreover, this study tends to neglect other factors such as classroom dynamics, school culture, colleagues’ rapport and students’ responses.Originality/valueGiven the novelty of Liberal Studies as a compulsory subject under the NSS curriculum and its specificity in Hong Kong education system, the amount of literature devoted to this area has been inadequate; among the available studies, the majority tend either to focus on the macro level, addressing the broader narratives of education policies and curriculum studies (e.g. Fung and Yip, 2010; Cheung and Leung, 1998) or to discuss the topic with exclusive reference to political transition and post-colonialism in the 1980s and 1990s (e.g. Morris and Chan, 1997). Studies on the micro level have generally paid little attention to the dynamics of Liberal Studies teaching, focusing instead on its relationships with other aspects such as private tutoring (Chan and Bray, 2014) and cultural representations of religion in Liberal Studies textbooks (Jackson and Han, 2016); pedagogical studies on the subject remain a minority.
The role of perceived values in explaining Vietnamese consumers’ attitude and intention to adopt mobile commerce
Authors: Khoi Nguyen Huu , Tuu Ho Huy , Olsen Svein Ottar 
Published: October 2018

Purpose
The purpose of this paper is to discuss and test the direct and indirect effects of utilitarian, hedonic and social values integrated into the theory of planned behaviour (TPB) to achieve a deeper understanding of consumers’ intention to adopt mobile commerce (MC) in the context of a developing country, Vietnam.

Design/methodology/approach
Based on self-administered survey data of 382 Vietnamese consumers, a structural equation modelling approach with latent constructs is used to test the hypotheses.

Findings
Perceived values explain consumer attitudes, subjective norms and behavioural intentions in the MC context. In particular, they help to increase the explained variance of the intention to adopt MC by about 9.58 per cent compared with the TPB. Finally, a cross-effect on consumer attitudes from subjective norms is also found.

Research limitations/implications
Future studies would benefit from investigating other variables (e.g. innovativeness or trust) and using actual behaviour (e.g. online purchases).

Practical implications
Business managers should pay attention to different forms of consumer values to understand how and why consumers adopt MC in a developing country.

Originality/value
This study fills the gap in the literature by simultaneously investigating the role of utilitarian, hedonic and social value in a TPB model in the MC context.
The impact of accreditation agencies and other powerful stakeholders on the performance measurement in Polish universities
Authors: Dobija Dorota , Górska Anna Maria , Pikos Anna 
Published: October 2018

PurposeThe purpose of this paper is to extend the understanding of how internal organisational processes change in response to external demands, by investigating the changes undertaken by two Polish business schools (b-schools) in anticipation of and in response to the demands of accreditation agencies (AAs) and other powerful stakeholders. Specifically, it examines the internal research-related performance measurement (PM) system and changes in the use of performance information (PI).Design/methodology/approachThe case study method is adopted, using data from publicly available documents and interviews with the faculty and management at the two schools. The data are interpreted and analysed using the neo-institutional theory.FindingsPowerful stakeholders are the primary reason for changes in PM systems and the manner in which PI is used. Specifically, AAs reflect an additional layer in the PM system, allowing for a downward cascading PI effect. This also leads to a wider use of PI across different organisational levels.Research limitations/implicationsThis study focusses on two case studies in a region still undergoing transition. Thus, this analysis could be reinforced through additional cases, different data collection methods and cross-country and between-country comparative analyses.Originality/valueThe changes in PM systems and particularly the use of PI are discussed in the context of Polish higher education (HE) and, more broadly, the entire Central and Eastern Europe (CEE) region. Moreover, the consideration of two b-school cases facilitates a comparative analysis of the differences in PM systems and the use of PI in the context of stakeholders’ PI needs.
Implementation obstacles and strategy implementation failure
Authors: Cândido Carlos J.F. , Santos Sérgio P. 
Published: October 2018

PurposeThe purpose of this paper is to address the following question: How do strategy implementation obstacles relate to each other and affect strategy implementation?Design/methodology/approachThe research methodology is qualitative and based on an extensive review of the literature and on an in-depth case study analysis.FindingsThis paper draws two main conclusions. The first is that the many obstacles that impact the strategy implementation process can interact and be strongly interrelated in dynamic and complex manners. The second is that obstacles can lead to and reinforce other obstacles, eventually forming long chains of blockages.Originality/valueStrategy implementation remains a difficult task with improbable success. This paper provides a contribution to an explanation on why so many strategy implementation efforts fail. It is one of the very few papers addressing the issue of the relationships between strategy implementation obstacles.
An application framework for mining online learning processes through event-logs
Authors: Özdağoğlu Güzin , Öztaş Gülin Zeynep , Çağliyangil Mehmet 
Published: October 2018

Purpose
Learning management systems (LMS) provide detailed information about the processes through event-logs. Process and related data-mining approaches can reveal valuable information from these files to help teachers and executives to monitor and manage their online learning processes. In this regard, the purpose of this paper is to present an overview of the current direction of the literature on educational data mining, and an application framework to analyze the educational data provided by the Moodle LMS.

Design/methodology/approach
The paper presents a framework to provide a decision support through the approaches existing in process and data-mining fields for analyzing the event-log data gathered from LMS platforms. In this framework, latent class analysis (LCA) and sequential pattern mining approaches were used to understand the general patterns; heuristic and fuzzy approaches were performed for process mining to obtain the workflows and statistics; finally, social-network analysis was conducted to discover the collaborations.

Findings
The analyses conducted in the study give clues for the process performance of the course during a semester by indicating exceptional situations, clarifying the activity flows, understanding the main process flow and revealing the students’ interactions. Findings also show that using the preliminary data analyses before process mining steps is also beneficial to understand the general pattern and expose the irregular ones.

Originality/value
The study highlights the benefits of analyzing event-log files of LMSs to improve the quality of online educational processes through a case study based on Moodle event-logs. The application framework covers preliminary analyses such as LCA before the use of process mining algorithms to reveal the exceptional situations.
Users’ influence on inter-organizational innovation: mapping the receptive context
Authors: Hedborg Bengtsson Susanna , Karrbom Gustavsson Tina , Eriksson Per Erik 
Published: October 2018

PurposeInnovation is constantly present in the construction industry, however, mainly on a single project level. Initiating and implementing inter-organizational innovation in a multi-project context such as in urban development entails large complexity, for example, because of the many interdependent projects and users of innovation. The users’ influence on inter-organizational innovation in a multi-project context has not been fully explored. Accordingly, the purpose of this paper is to discuss how users influence inter-organizational innovation in multi-project contexts by mapping the receptiveness for change.Design/methodology/approachA single case study approach was used, where empirical material including semi-structured interviews in combination with meeting observations, document studies and participative workshops were gathered. The rich empirical material, studying inter-organizational innovation in an urban development context, was mapped based on the receptive context for change framework.FindingsA receptive context for change was not present in the studied multi-project context. Communication to develop and implement inter-organizational innovation was not sufficient and the clients’ procurement strategies were to a large extent not developed to facilitate inter-organizational innovation. Findings show differences in users’ possibility and aim to implement inter-organizational innovation.Originality/valueThe mapping of the receptive context to influence inter-organizational innovation widens the knowledge base and provides valuable insights on how inter-organizational innovation may be implemented in the loosely coupled construction industry. Furthermore, the findings broaden the discussion on clients as innovation supporters, and contribute to the debate on clients as innovation supporters, by highlighting the importance of distinguishing between different types of clients.
Oral reading: practices and purposes in secondary classrooms
Authors: Brooks Maneka Deanna , Frankel Katherine K. 
Published: October 2018

PurposeThis paper aims to investigate teacher-initiated whole-group oral reading practices in two ninth-grade reading intervention classrooms and how teachers understood the purposes of those practices.Design/methodology/approachIn this qualitative cross-case analysis, a literacy-as-social-practice perspective is used to collaboratively analyze ethnographic data (fieldnotes, audio recordings, interviews, artifacts) across two classrooms.FindingsOral reading was a routine instructional reading event in both classrooms. However, the literacy practices that characterized oral reading and teachers’ purposes for using oral reading varied depending on teachers’ pedagogical philosophies, instructional goals and contextual constraints. During oral reading, students’ opportunities to engage in independent meaning making with texts were either absent or secondary to other purposes or goals.Practical implicationsFindings emphasize the significance of understanding both how and why oral reading happens in secondary classrooms. Specifically, they point to the importance of collaborating with teachers to (a) examine their own ideas about the power of oral reading and the institutional factors that shape their existing oral reading practices; (b) investigate the intended and actual outcomes of oral reading for their students and (c) develop other instructional approaches to support students to individually and collaboratively make meaning from texts.Originality/valueThis study falls at the intersection of three under-researched areas of study: the nature of everyday instruction in secondary literacy intervention settings, the persistence of oral reading in secondary school and teachers’ purposes for using oral reading in their instruction. Consequently, it contributes new knowledge that can support educators in creating more equitable instructional environments.