bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal-Organic Frameworks as advanced moisture sorbents for energy-efficient high temperature cooling
Authors: Cui Shuqing , Qin Menghao , Marandi Afsaneh , Steggles Victoria , Wang Sujing , Feng Xiaoxiao , Nouar Farid , Serre Christian 
Published: October 2018

AbstractLatent cooling load accounts for 30% of the total load of air-conditioning, and its proportion is even higher in many tropical and subtropical climates. Traditional vapour-compression air-conditioning (VCAC) has a low coefficient of performance (COP) due to the refrigeration dehumidification process, which often makes necessary a great deal of subsequent re-heating. Technologies using conventional desiccants or sorbents for indoor moisture control are even less competitive than VCAC due to their high regeneration temperature, long cycling time and bulky components. Here, we report a novel high temperature cooling system that uses porous metal-organic frameworks (MOFs) as advanced sorbents for humidity control. We directly coat MOFs on the surface of evaporator and condenser. The system has no additional components compared to a traditional VCAC. The evaporator can simultaneously remove both the sensible and latent loads of the incoming air without reducing the temperature below its dew point. The regeneration of wet MOFs is completely driven by the residual heat from the condenser. The MOF-coated heat exchangers can achieve a cooling power density of 82 W·L−1. We demonstrate that the system has a high COP, up to 7.9, and can save 36.1% of the energy required, compared to the traditional VCAC system with reheating. The amphiphilic MOFs used in the research have high water uptake, are made of low-cost raw materials and have high hydrothermal stability. They thus have the potential for being scaled up for large-scale applications in air conditioning.
ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid
Authors: Dubiel Andrzej , Wegrzyn Katarzyna , Kupinski Adam P. , Konieczny Igor 
Published: October 2018

AbstractThe activity of type II toxin-antitoxin systems (TA), which are responsible for many important features of bacterial cells, is based on the differences between toxin and antitoxin stabilities. The antitoxin lability results from bacterial protease activity. Here, we investigated how particular Escherichia coli cytosolic proteases, namely, Lon, ClpAP, ClpXP, and ClpYQ, affect the stability of both the toxin and antitoxin components of the parDE system from the broad host range plasmid RK2. The results of our in vivo and in vitro experiments show that the ParD antitoxin is degraded by the ClpAP protease, and dsDNA stimulates this process. The ParE toxin is not degraded by any of these proteases and can therefore cause growth inhibition of plasmid-free cells after an unequal plasmid distribution during cell division. We also demonstrate that the ParE toxin interaction with ParD prevents antitoxin proteolysis by ClpAP; however, this interaction does not prevent the ClpAP interaction with ParD. We show that ClpAP protease homologs affect plasmid stability in other bacterial species, indicating that ClpAP is a universal activator of the parDE system and that ParD is a universal substrate for ClpAP.
Concatenation of the Moving Window Technique for Auditory-Perceptual Analysis of Voice Quality
Authors: Ehrlich Benjamin , Lin Liyu , Jiang Jack 
Published: October 2018

Purpose
The purpose of this study is to develop a program to concatenate acoustic vowel segments that were selected with the moving window technique, a previously developed technique used to segment and select the least perturbed segment from a sustained vowel segment. The concatenated acoustic segments were compared with the nonconcatenated, short, individual acoustic segments for their ability to differentiate normal and pathological voices. The concatenation process sometimes created a clicking noise or beat, which was also analyzed to determine any confounding effects.

Method
A program was developed to concatenate the moving window segments. Listeners with no previous rating experience were trained and, then, rated 20 normal and 20 pathological voice segments, both concatenated (2 s) and short (0.2 s) for a total of 80 segments. Listeners evaluated these segments on both the Grade, Roughness, Breathiness, Asthenia, and Strain scale (GRBAS; 8 listeners) and the Consensus Auditory-Perceptual Evaluation of Voice (Kempster, Gerratt, Abbott, Barkmeier-Kraemer, & Hillman, 2009) scale (7 listeners). The sensitivity and specificity of these ratings were analyzed using a receiver-operating characteristic curve. To evaluate if there were increases in particular criteria due to the beat, differences between beat and nonbeat ratings were compared using a 2-tailed analysis of variance.

Results
Concatenated segments had a higher sensitivity and specificity for distinguishing pathological and normal voices than short segments. Compared with nonbeat segments, the beat had statistically similar increases for all criteria across Consensus Auditory-Perceptual Evaluation of Voice and GRBAS scales, except pitch and loudness.

Conclusions
The concatenated moving window method showed improved sensitivity and specificity for detecting voice disorders using auditory-perceptual analysis, compared with the short moving window segment. It is a helpful tool for perceptual analytic protocols, allowing for voice evaluation using standardized and automated voice-segmenting procedures.

Supplemental Material

https://doi.org/10.23641/asha.7100951
Ultra‐low‐voltage low‐power dynamic comparator with forward body bias scheme for SAR ADC
Authors: Hwang Young‐Ha , Jeong Deog‐Kyoon 
Published: October 2018

An ultra‐low‐voltage two‐stage dynamic comparator is proposed with a forward body bias (FBB) scheme for successive approximation register (SAR) analogue‐to‐digital converters (ADCs). The proposed FBB scheme for a preamplifier and latch stage reduces the delay time remarkably under a low supply voltage. At 0.4 V, the power consumption is 4.48 nW, and the delay can be decreased to 593.9 ns for ΔVin = 0.1 mV and fclk = 100 kHz. The RMS equivalent input‐referred noise of the comparator is 0.136 mV. The total offset is 13.7 mV, and offset fluctuation is 0.183 mV with the proposed structure. Both the input‐referred noise and offset fluctuation are <0.5 least‐significant bit for a 10‐bit SAR ADC at 0.4 V.
S‐PS resonant topology of WPT system for implantable spinal cord stimulator
Authors: Lu Yuehai , Qiu Dongyuan , Meng Xiantian , Zhang Bo , Chun Tang Sai 
Published: October 2018

Magnetic resonance‐based wireless power transfer (WPT) system offers a promising solution to provide power for implantable spinal cord stimulator (SCS). To meet with the clinical requirements, the SCS‐WPT system should have high transfer efficiency and long transfer distance. As the topology of the resonant network will directly affect the transfer efficiency and output power of the WPT system, a new resonant network, series‐parallel and series (S‐PS), is selected in this work. The performance of WPT system with S‐PS resonant network has been compared with those with the classic resonance networks, it is concluded that S‐PS is the suitable resonant network for the WPT system in a wide range of load. Finally, an SCS‐WPT prototype with S‐PS resonant network is built with detailed parameter design to verify the correctness of theoretical analysis. The system efficiency is up to 68.4% at a coil separation of 50 mm.
Quantifying colorimetric assays in µPAD for milk adulterants detection using colorimetric android application
Authors: Salve Mary , Wadafale Ashwini , Dindorkar Gurushree , Kalambe Jayu 
Published: October 2018

A microfluidic paper‐based analytical device (μ‐PAD) and handheld colorimeter android application for quantifying the precise concentration of adulterants in milk are developed. A simple method to pattern polydimethylsiloxane for creating a hydrophobic barrier on filter paper using custom‐designed rubber stamp containing the design of μ‐PAD was used. The experiments were performed for the detection of urea, starch, salt and detergent ranging from 1 to 100 mg in 10 ml of milk. The user just needs to pipette drops of adulterated milk on a test spot and the results are obtained instantly. The authors believe that the developed platform can be used as a basis for low‐cost, portable system for various fluid adulterants’ tests. The experimental database was used for the development of a colorimetric android application to calibrate the colour range for adulterants’ concentration detection. The limit of detection of colorimetric android application for adulterants urea is 5 mg, starch is 17 mg, salt is 29 mg and for detergent is 20 mg in 10 ml of milk. This kind of system is attractive for use in developing countries, in the field, or as an inexpensive alternative as compared with other methods for water and food safety.
Belastungsuntersuchungen in der Pneumologie – Empfehlungen der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V.
Authors: Meyer F. , Borst M. , Buschmann H.-C. , Claussen M. , Dumitrescu D. , Ewert R. , Friedmann-Bette B. , Gläser S. , Glöckl R. , Haring K. , Lehnigk B. , Ochmann U. , Preisser A. , Sorichter S. , Westhoff M. , Worth H. 
Published: October 2018

ZusammenfassungDieses Dokument der DGP ersetzt die Empfehlungen von 1998 und 2013. Anhand der aktuellen Datenlage und einer Konsensuskonferenz wurden Empfehlungen zu Indikationen, zur Auswahl und Durchführung der geeigneten Belastungsuntersuchungen sowie zu den technischen und personellen Voraussetzungen formuliert. Detaillierte Angaben werden zur Blutgasanalyse unter Belastung, zu Gehtests und Rechtsherzkatheter unter Belastung sowie zur Spiroergometrie und Stressechokardiografie gemacht. Der korrekte Einsatz von Belastungsuntersuchungen bei anstrengungsinduziertem Asthma, bei sport-, arbeits- bzw. rehabilitationsmedizinischen Fragestellungen, bei Adipositas, bei der präoperativen Risikostratifizierung und beim Therapiemonitoring pneumologischer Erkrankungen wird dargestellt.
Neuroendokrine Neoplasien im deutschen NET-Register
Authors:   Authors,   Im Namen aller Teilnehmer/innen am Deutschen NET-Registers,   Kollaboratoren:
Published: October 2018

ZusammenfassungNeuroendokrine Neoplasien (NEN) umfassen eine seltene Tumorentität mit heterogener Biologie, Prognose und therapeutischen Optionen. In Zusammenhang mit der kürzlichen Publikation der ersten deutschen Leitlinie zur Diagnostik und Therapie von NEN erfolgte die Analyse der Kohorte des Deutschen NET-Registers der Deutschen Gesellschaft für Endokrinologie (DGE). Hierzu wurden 2686 Fälle extrahiert und ihre Patientencharakteristika wie Alter, Geschlecht, Primärtumorlokalisation, Grading und Staging dargestellt sowie das Gesamtüberleben berechnet. Zusätzlich wurden die systemischen Behandlungsstrategien in den beiden größten Untergruppen, NEN des Dünndarms und Pankreas, im Stadium der Metastasierung analysiert.Die Verteilung der Primärtumoren, die histopathologische Charakterisierung, das Tumorstadium sowie das Gesamtüberleben waren vergleichbar mit den Ergebnissen internationaler Registerstudien. Somatostatinanaloga (SSA) und die Peptid-Rezeptor-Radionuklid-Therapie (PRRT) waren die häufigsten systemischen Therapieverfahren bei Dünndarm-NEN. Hingegen wurde eine Chemotherapie – in Übereinstimmung mit der neuen Leitlinie – vor allem bei pankreatischen NEN eingesetzt und kam in der Erstlinie in ähnlicher Frequenz wie die SSA-Therapie bzw. in der Zweitlinie ähnlich häufig wie eine PRRT zum Einsatz. Prognostisch relevante Parameter waren die WHO-Klassifikation 2010 und das TNM-Staging.Die aktuelle Analyse des deutschen NET-Registers charakterisiert damit eine multizentrische, interdisziplinäre, deutschlandweite Kohorte von NEN-Patienten und beschreibt die angewendeten systemischen Therapieverfahren, das Gesamtüberleben und die prognostische Bedeutung der WHO-Klassifikation 2010 sowie des TNM-Stadiums.
Setting Up Workflow of an Intraoperative MRI Unit: A Single-Centre Experience of First 53 Cases
Authors: Manohar Nitin , Mohapatra Deviprasad , Balasubramaniam Anandh , Rao Keerthi , Srinivas Deepti , Chakrabarti Dhritiman 
Published: October 2018

Abstract
Background Setting up of a new “nearby” operation room type intraoperative magnetic resonance imaging (iMRI) unit poses a unique set of challenges to the operating team. We describe here an account of our experiences and a step by step protocol designed by us and followed to troubleshoot the issues encountered. The primary objective of the study was to observe our learning curve in the process of setting up of a new iMRI unit. The secondary objectives were to look at the number of residues detected, quality of imaging, and complications during iMRI.
Materials and Methods An observational study was conducted over a 3-month period involving cases requiring iMRI. Initially, a simulation was performed using healthy volunteers, which helped in developing a systematic protocol and drafting checklists to ensure a smooth workflow pattern. Data collection included details regarding hindrances encountered, how these were tackled, iMRI details (residual tumor, re-surgery), and complications, if any.
Results A total of 53 cases underwent iMRI in the study period. Among these, 51 were tumor cases that revealed residue (detected in 28 [54.9%] cases), and re-surgery for further resection was performed in 21/28 (75%) cases. A very high level of surgeons’ satisfaction regarding image quality of intraoperative scan was recorded (45/53 [84%]). The number of personnel required for shifting and shifting times could be reduced with efficient utilization of the checklist.
Conclusion A methodical approach to tackle impediments while setting up a new unit such as iMRI facilitates its smooth functioning and ensures minimal interruptions and evades undue complications.
Postural control of Parkour athletes compared to recreationally active subjects under different sensory manipulations: A pilot study
Authors: Jabnoun Salim , Borji Rihab , Sahli Sonia 
Published: October 2018

AbstractIn Parkour activity, the aim is to move from one place to another as quickly and efficiently as possible by running, climbing, swinging, vaulting, rolling, crawling and jumping on tiny obstacles … . Performing these actions places a great demand on the postural control system. The purpose of the present study was to investigate postural control of Parkour practitioners – called Traceurs – compared to recreationally active (RA) subjects in different postural conditions after manipulating the visual and/or proprioceptive sensory inputs. Ten Traceurs (mean experience 5.9 ± 0.9 years; >5 hours per week) and 10 RA subjects participated in this study. We measured the centre of pressure area (CoPA) of the upright standing bipedal and unipedal postures in different postural conditions: on a firm and on a foam surfaces; on an oscillating surface in the sagittal plane and in the frontal plane in eyes open and eyes closed. To evaluate vision contribution, the Romberg index (RI) was calculated. Results showed that Traceurs presented a significant (P < .001) lower CoPA values compared to RA subjects in eyes closed condition, suggesting that they were able to maintain a better balance control when vision is removed. Traceurs seems to be less dependent on visual cues (lower RI values) and proprioceptive inputs for maintaining balance than RA subjects. According to our study, Parkour training (experience for at least five years with a minimum of five hours per week) may improve postural abilities of young adult practitioners in specific postural conditions.
Colocalization analyses of genomic elements: approaches, recommendations and challenges
Authors: Kanduri Chakravarthi , Bock Christoph , Gundersen Sveinung , Hovig Eivind , Sandve Geir Kjetil 
Published: October 2018

AbstractMotivationMany high-throughput methods produce sets of genomic regions as one of their main outputs. Scientists often use genomic colocalization analysis to interpret such region sets, for example to identify interesting enrichments and to understand the interplay between the underlying biological processes. Although widely used, there is little standardization in how these analyses are performed. Different practices can substantially affect the conclusions of colocalization analyses.ResultsHere, we describe the different approaches and provide recommendations for performing genomic colocalization analysis, while also discussing common methodological challenges that may influence the conclusions. As illustrated by concrete example cases, careful attention to analysis details is needed in order to meet these challenges and to obtain a robust and biologically meaningful interpretation of genomic region set data.Supplementary informationSupplementary data are available at Bioinformatics online.
Severe Pertussis Infections in the United States, 2011–2015
Authors: Mbayei Sarah A , Faulkner Amanda , Miner Christine , Edge Karen , Cruz Victor , Peña Sandra A , Kudish Kathy , Coleman Joan , Pradhan Eva , Thomas Stepy , Martin Stacey , Skoff Tami H 
Published: October 2018

Abstract

Background
The incidence of pertussis in the United States has increased in recent years. While characteristics of severe pertussis infection have been described in infants, fewer data are available in older children and adults. In this analysis, we characterize pertussis infections in hospitalized patients of all ages.

Methods
Cases of pertussis with cough onset from 1 January 2011 through 31 December 2015 from 7 US Emerging Infections Program Network states were reviewed. Additional information on hospitalized patients was obtained through abstraction of the inpatient medical record. Descriptive and multivariable analyses were conducted to characterize severe pertussis infection and identify potential risk factors.

Results
Among 15942 cases of pertussis reported, 515 (3.2%) were hospitalized. Three hospitalized patients died. Infants aged <2 months accounted for 1.6% of all pertussis cases but 29.3% of hospitalizations. Infants aged 2–11 months and adults aged ≥65 years also had high rates of hospitalization. Infants aged <2 months whose mothers received acellular pertussis during the third trimester and children aged 2 months to 11 years who were up to date on pertussis-containing vaccines had a 43%–66% reduced risk of hospitalization. Among adolescents aged 12–20 years, 43.5% had a history of asthma, and among adults aged ≥65 years, 26.8% had a history of chronic obstructive pulmonary disease.

Conclusions
Individuals at the extreme ends of life may be the most vulnerable to severe pertussis infections, though hospitalization was reported across all age groups. Continued monitoring of severe pertussis infections will be important to help guide prevention, control, and treatment options.
Peak oxygen uptake and incident coronary heart disease in a healthy population: the HUNT Fitness Study
Authors: Letnes Jon Magne , Dalen Håvard , Vesterbekkmo Elisabeth K , Wisløff Ulrik , Nes Bjarne M 
Published: October 2018

Abstract

Aims
The majority of previous research on the association between cardiorespiratory fitness (CRF) and cardiovascular disease (CVD) is based on indirect assessment of CRF in clinically referred predominantly male populations. Therefore, our aim was to examine the associations between VO2peak measured by the gold-standard method of cardiopulmonary exercise testing and fatal and non-fatal coronary heart disease (CHD) in a healthy and fit population.

Methods and results
Data on VO2peak from 4527 adults (51% women) with no previous history of cardiovascular or lung disease, cancer, and hypertension or use of antihypertensive medications participating in a large population-based health-study (The HUNT3 Study), were linked to hospital registries and the cause of death registry. Average VO2peak was 36.0 mL/kg/min and 44.4 mL/kg/min among women and men, and 83.5% had low 10-year risk of CVD at baseline. Average follow-up was 8.8 years, and 147 participants reached the primary endpoint. Multi-adjusted Cox-regression showed 15% lower risk for the primary endpoint per one-MET (metabolic equivalent task) higher VO2peak [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.93], with similar results across sex. The highest quartile of VO2peak had 48% lower risk of event compared with the lowest quartile (multi-adjusted HR 0.52, 95% CI 0.33–0.82). Oxygen pulse and ventilatory equivalents of oxygen and carbon dioxide also showed significant predictive value for the primary endpoint.

Conclusion
VO2peak was strongly and inversely associated with CHD across the whole fitness continuum in a low-risk population sample. Increasing VO2peak may have substantial benefits in reducing the burden of CHD.
Association of patient-reported experiences with health resource utilization and cost among US adult population, medical expenditure panel survey (MEPS), 2010–13
Authors: Nasir Khurram , Okunrintemi Victor 
Published: October 2018

Abstract

Objectives
To determine whether optimal patient experiences with healthcare is associated with enhanced and efficient use of healthcare resources and cost.

Design
Retrospective cohort study.

Setting and participants
The study population consisted of pooled participants from the 2010–13 Medical Expenditure Panel Survey cohort of adults ≥18 years with a regular healthcare provider and ≥1 visit to a healthcare provider within the survey year. Using a self-administered questionnaire, individual responses to questions related to healthcare experience were used to develop a weighted average for each of these patient-centered care matrices (ease of access to healthcare, patient–provider communication, shared decision-making and overall patient satisfaction).

Intervention
None.

Outcome measures
The outcomes of interest included (1) emergency room (ER) visits and hospital stay, (2) annual healthcare costs incurred by the respondents.

Results
Overall the study population consisted of 47 969 individuals ≥18 years representing nearly 130 million US non-institutionalized adults. Compared with individuals with a poor report on healthcare experience, participants with positive reports were less likely to utilize the ER and had a lower annual healthcare expenditure. This relationship between patient experience and healthcare expenditure was not demonstrated with shared decision-making and overall patient satisfaction.

Conclusion
Our study findings suggest that there is an association between patient experience with healthcare, health resource utilization and healthcare expenditure. Further studies are needed to assess if interventions focused to enhance patient experiences can improve healthcare efficiency.