bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroanalytical Determination of Vancomycin at a Graphene‐modified Electrode: Comparison of Electrochemical Property between Graphene, Carbon Nanotube, and Carbon Black
Authors: Hadi Mojtaba , Mollaei Tahere 
Published: November 2018

AbstractCarbon nanotube, graphene and carbon black, as electrode modifiers, were compared and evaluated for the electrochemical determination of vancomycin. Among them, the best results were obtained at the graphene‐modified electrode. Additions of vancomycin using square wave voltammetry at the graphene‐modified electrode showed a linear range from 0.70 μM to 50 μM and a detection limit of 0.20 μM was obtained. To control the correct dose of vancomycin and reduce its side effects, its accurate determination in blood plasma is very important. Therefore, the method was applied for the vancomycin determination in spiked human plasma samples and satisfactory recoveries were observed. The developed method exhibited fast analysis, high sensitivity, good repeatability and freedom from other interfering species.
Low cell surface hydrophobicity is one of the key factors for high butanol tolerance of Lactic acid bacteria
Authors: Petrova Penka , Tsvetanova Flora , Petrov Kaloyan 
Published: November 2018

AbstractHighly butanol‐tolerant strains have always been attractive because of their potential as microbial hosts for butanol production. However, due to the amphiphilic nature of 1‐butanol as a solvent, the relationship between the cell surface hydrophobicity and butanol resistance remained ambiguous to date. In this work, the quantitatively estimated cell surface hydrophobicity of 74 Lactic acid bacteria strains were juxtaposed to their tolerance to various butanol concentrations. The obtained results revealed that the strains’ hydrophobicity was inversely proportional to their butanol tolerance. All highly butanol‐resistant strains were hydrophilic (cell surface hydrophobicity<1%), whereas the more hydrophobic the strains were, the more sensitive to butanol they were. Furthermore, cultivation at increasing butanol concentrations showed a clear tendency to decrease the level of hydrophobicity in all tested organisms, thus suggesting possible adaptation mechanisms. Purposeful reduction of cell surface hydrophobicity (by removal of S‐layer proteins from the cell envelope) also led to an increase of butanol resistance. Since the results covered 23 different Lactic acid bacteria species of seven genera, it could be concluded that regardless of the species, the lower degree of cells’ hydrophobicity clearly correlates with the higher level of butanol tolerance.
Increased Marginal Stiffness Differentiates Infiltrative From Noninfiltrative Cutaneous Basal Cell Carcinomas in the Facial Area: A Prospective Study
Authors: Alfageme Fernando , Salgüero Irene , Nájera Laura , Suarez Masa L. , Roustan Gastón 
Published: November 2018

ObjectivesBasal cell carcinoma (BCC) is the most common dermatologic malignant skin cancer. Infiltrative histologic variants are more aggressive and require wider surgical margins or Mohs surgery, in contrast with noninfiltrative variants, which are commonly treated with standard surgical excision. Elastography has not been used to date to differentiate between the histologic variants of BCC. The purpose of this study was to differentiate infiltrative from noninfiltrative BCCs on elastography.MethodsA total of 31 facial BCCs were studied. Preoperatively, color Doppler ultrasound and strain elastographic examinations of the lesions were performed. The size, intralesional vascularization, and presence of hyperechoic dots were considered relevant B‐mode and color Doppler variables. Strain ratios of the tumors were obtained with respect to adjacent healthy tissue. Increased marginal stiffness, which was considered hardness in greater than 50% of the tumor margin, was also blindly evaluated. Histologic confirmation and subtyping (infiltrative or noninfiltrative) were performed in all cases.ResultsInfiltrative BCCs did not differ in the size, presence or absence of hyperechoic dots, or vascularization from noninfiltrative BCCs. Strain ratios were similar in both infiltrative and noninfiltrative BCCs (mean ± SD, 1.82 ± 0.879 versus 2.2 ± 1.11). However, infiltrative BCCs had statistically increased marginal stiffness in comparison with noninfiltrative BCCs (88.0% versus 18.8%). Increased marginal stiffness had sensitivity and specificity of 0.89 and 0.82 respectively, with a positive predictive value of 0.67 for infiltrative BCCs and a negative predictive value of 0.95 for noninfiltrative BCCs.ConclusionsHistologic variants of BCC have different elastographic patterns. These differences may be of help in preoperative assessments of the BCC subtype and specific surgical planning, avoiding unnecessary skin biopsies.
Lindelöf theorems for monotone Sobolev functions in Orlicz spaces on uniform domains
Authors: Futamura Toshihide , Shimomura Tetsu 
Published: November 2018

AbstractIn this paper, we are concerned with Lindelöf type theorems for monotone (in the sense of Lebesgue) Sobolev functions u on a uniform domain satisfying
urn:x-wiley:0025584X:media:mana201800014:mana201800014-math-0002where ∇ denotes the gradient, denotes the distance from z to the boundary , φ is of log‐type and ω is a weight function satisfying the doubling condition.
Baseline predictors for progression 4 years after Parkinson's disease diagnosis in the De Novo Parkinson Cohort (DeNoPa)
Authors: Mollenhauer Brit , Zimmermann Johannes , Sixel‐Döring Friederike , Focke Niels K. , Wicke Tamara , Ebentheuer Jens , Schaumburg Martina , Lang Elisabeth , Friede Tim , Trenkwalder Claudia ,   on behalf of the DeNoPa Study Group
Published: November 2018

AbstractObjectivesThe objectives of this study were to investigate (1) the annual rate of progression of motor and cognitive symptoms and (2) baseline predictors of different modalities for this progression in early Parkinson's disease (PD) when compared with healthy controls.MethodsA total of 135 de novo PD and 109 healthy controls (of the De Novo Parkinson cohort) were investigated at baseline and after 24 and 48 months. To delineate motor progression and cognitive decline, the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale part III (MDS‐UPDRS III) and the Mini‐Mental Status Examination (MMSE) were selected. Baseline variables used to predict progression included sociodemographic factors, comorbidities, motor/nonmotor symptoms, polysomnography, MRI, and laboratory biomarkers in serum and CSF.ResultsSymptoms worsened over 4 years in PD with an annual change of 1.8 points on the MDS‐UPDRS III and 0.2 points on the MMSE. Baseline predictors of worse progression of motor symptoms in PD included male sex, orthostatic blood pressure drop, diagnosis of coronary artery disease, arterial hypertension, elevated serum uric acid, and CSF neurofilament light chain. Predictors of cognitive decline in PD included previous heavy alcohol abuse, current diagnoses of diabetes mellitus, arterial hypertension, elevated periodic limb movement index during sleep, decreased hippocampal volume by MRI, higher baseline levels of uric acid, C‐reactive protein, high density lipoprotein (HDL) cholesterol, and glucose levels.ConclusionCardiovascular risk factors, deregulated blood glucose, uric acid metabolism, and inflammation were identified as risk markers for faster disease progression. Our panel of risk parameters needs validation during our continuing follow‐up and also in independent patient cohorts. © 2018 International Parkinson and Movement Disorder Society
Bimolecular Nucleophilic Substitution Reactions: Predictive Models for Rate Constants and Molecular Reaction Pairs Analysis
Authors: Gimadiev Timur , Madzhidov Timur , Tetko Igor , Nugmanov Ramil , Casciuc Iury , Klimchuk Olga , Bodrov Andrey , Polishchuk Pavel , Antipin Igor , Varnek Alexandre 
Published: November 2018

AbstractHere, we report the data visualization, analysis and modeling for a large set of 4830 SN2 reactions the rate constant of which (logk) was measured at different experimental conditions (solvent, temperature). The reactions were encoded by one single molecular graph – Condensed Graph of Reactions, which allowed us to use conventional chemoinformatics techniques developed for individual molecules. Thus, Matched Reaction Pairs approach was suggested and used for the analyses of substituents effects on the substrates and nucleophiles reactivity. The data were visualized with the help of the Generative Topographic Mapping approach. Consensus Support Vector Regression (SVR) model for the rate constant was prepared. Unbiased estimation of the model's performance was made in cross‐validation on reactions measured on unique structural transformations. The model's performance in cross‐validation (RMSE=0.61 logk units) and on the external test set (RMSE=0.80) is close to the noise in data. Performances of the local models obtained for selected subsets of reactions proceeding in particular solvents or with particular type of nucleophiles were similar to that of the model built on the entire set. Finally, four different definitions of model's applicability domains for reactions were examined.
A new wide stopband and high gain quasi‐Yagi filtering antenna
Authors: Zheng Licheng , Zhai Huiqing , Wei Zichun , Ma Shaobo , Shi Junhao 
Published: November 2018

AbstractIn this letter, a new wide stopband and high gain Quasi‐Yagi filtering antenna is proposed. At the beginning of feeder line in the improved Balun filtering antenna, it is integrated with the stripline low‐pass filter that contributes to wide out‐of‐band suppression. The proposed filtering antenna works from 2.25 GHz to 2.55 GHz, with a maximum gain of 8dBi at 2.5 GHz. Moreover, it possesses a faster roll‐off rate from 2.55 GHz(8 dB) to 2.8 GHz (−20 dB) and a better rejection up to 12 GHz(5 times of central frequency) outside the working band.
Comparative Nuclear Proteomics Analysis Provides Insight into the Mechanism of Signaling and Immune Response to Blast Disease Caused by Magnaportheoryzae in Rice
Authors: Narula Kanika , Choudhary Pooja , Ghosh Sudip , Elagamey Eman , Chakraborty Niranjan , Chakraborty Subhra 
Published: November 2018

AbstractModulation of plant immune system by extrinsic/intrinsic factors and host‐specific determinants fine‐tunes cellular components involving multiple organelles, particularly nucleus to mount resistance against pathogen attack. Rice blast, caused by hemibiotrophic fungus Magnaporthe oryzae, is one of the most devastating diseases that adversely affect rice productivity. However, the role of nuclear proteins and their regulation in response to M. oryzae remains unknown. Here, the nucleus‐associated immune pathways in blast‐resistant rice genotype are elucidated. Temporal analysis of nuclear proteome is carried out using 2‐DE coupled MS/MS analysis. A total of 140 immune responsive proteins are identified associated with nuclear reorganization, cell division, energy production/deprivation, signaling, and gene regulation. The proteome data are interrogated using correlation network analysis that identified significant functional modules pointing toward immune‐related coinciding processes through a common mechanism of remodeling and homeostasis. Novel clues regarding blast resistance include nucleus‐associated redox homeostasis and glycolytic enzyme–mediated chromatin organization which manipulates cell division and immunity. Taken together, the study herein provides evidence that the coordination of nuclear function and reprogramming of host translational machinery regulate resistance mechanism against blast disease.
Theoretical investigation on atmospheric reaction of O(3P) with CH2CN
Authors: Zhang Yunju , Sun Yuxi 
Published: November 2018

AbstractThe degradation reaction of CH2CN radical with O(3P) was firstly studied using quantum chemical methods. The energetics were calculated at CCSD(T)/cc‐pVTZ//B3LYP/6‐311++G(d,p). The formation of the intermediate C‐IM1 (CH2C(O)N) is the dominant channel by addition between O(3P) and the central‐C atom of CH2CN. Due to higher barriers, the terminal‐C‐addition/elimination, N‐addition/elimination, substitution and hydrogen abstraction channels are negligible. The rate constants were calculated by means of the RRKM‐TST theory. The total rate constants revealed positive temperature dependence and pressure independence. The calculated results were in good agreement with the experimental values.
Catalytic role of 16‐s‐16 micelles on condensation reaction of ninhydrin and metal‐dipeptide complex
Authors: Kumar Dileep , Rub Malik Abdul 
Published: November 2018

AbstractCatalytic role of 16‐s‐16 (s = spacer) micelles on condensation reaction of ninhydrin and metal‐dipeptide ([Cu (II)‐Gly‐Leu]+) complex have been studied by varying reactants concentration at various temperatures ranges from 333 K to 353 K. The reaction was monitored at definite time interval with the help of UV‐vis spectrophotometer. For evaluation of critical micelle concentration (cmc) of 16‐s‐16 surfactants with and without reactants (ninhydrin and metal‐dipeptide complex), conductometic technique was used throughout the study. During kinetic runs, study confirms the first‐order path in complex and fractional‐order path in ninhydrin. Rate constant (kψ) increased with rise in [16‐s‐16] below cmc value, then became almost constant with further increase in concentration (like conventional surfactants). Great enhancement in rate value was noted at higher surfactant concentrations. The rate enhancement below and above cmc values of 16‐s‐16 surfactants has been accounted in the light of pseudo‐phase model. Kinetic data were used to calculate several factors including micelle‐substrate binding constants and thermodynamic parameters.
Motivation matters: Development and validation of the Motivation for Solitude Scale – Short Form (MSS‐SF)
Authors: Thomas Virginia , Azmitia Margarita 
Published: November 2018

ABSTRACTIntroductionMotivation is an overlooked but crucial factor in determining whether solitude is psychologically beneficial or risky. This paper describes the development and validation of the Motivation for Solitude Scale ‐ Short‐Form (MSS‐SF), a measure grounded in Self‐Determination Theory that differentiates between intrinsic versus extrinsic motivations for solitude.MethodsEmerging adult (N = 803) and adolescent (N = 176) participants were recruited in four successive samples from the United States for the purposes of scale development and validation. Participants completed an on‐line survey that included the MSS‐SF and various well‐being and personality measures.Results & conclusionsConfirmatory Factor Analyses resulted in a two‐factor solution, selfdetermined solitude (SDS) and not self‐determined solitude (NSDS), and showed the MSS‐SF to be reliable with adolescents and emerging adults, with satisfactory convergent and discriminant validity. Engaging in solitude for extrinsic, not self‐determined reasons was associated with loneliness, social anxiety, and depressive symptomatology; in contrast, solitude chosen for intrinsic, self‐determined reasons was positively correlated with well‐being, for emerging adults in particular. The MSS‐SF goes beyond preference for solitude to distinguish two distinctly different motivations for solitude, and in so doing, allows researchers to better understand the affordances and risks of being alone for adolescents and emerging adults.
State, institutions and reform in Turkey after July 15
Authors: Aras Bülent , Yorulmazlar Emirhan 
Published: November 2018

AbstractThe failed coup of July 15 has shocked the current state apparatus in Turkey. This shock has culminated in the public demand for administrative reform, which would make previous public designs and policy failures a matter of the past. The state crisis has transpired in the middle of a political transition process whereby the ruling party envisioned systemic change in the political system from the parliamentary to a presidential system. The constitutional amendments also imply changes in the administrative order, with further political hold on bureaucratic cadres. The coup attempt and the massive purges in its aftermath brought the state to its breaking point. In light of such deficits and challenges, this paper discusses the ways, means, and prospects for capacity development and institution-building to overcome the state crisis in Turkey. The reform and restructuring process entails cooperation and a level of understanding between the government, opposition, and bureaucracy. Polarization and disenfranchisement are recipes for further fragmentation in Turkish politics. A cooperative model based on a working relationship between the government, opposition, and bureaucracy would facilitate a return to normalcy.
Climate change and the latitudinal selectivity of ancient marine extinctions
Authors: Reddin Carl J. , Kocsis Ádám T. , Kiessling Wolfgang 
Published: November 2018

AbstractGeologically rapid climate change is anticipated to increase extinction risk nonuniformly across the Earth's surface. Tropical species may be more vulnerable than temperate species to current climate warming because of high tropical climate velocities and reduced seawater oxygen levels. To test whether rapid warming indeed preferentially increased the extinction risk of tropical fossil taxa, we combine a robust statistical assessment of latitudinal extinction selectivity (LES) with the dominant views on climate change occurring at ancient extinction crises. Using a global data set of marine fossil occurrences, we assess extinction rates for tropical and temperate genera, applying log ratios to assess effect size and Akaike weights for model support. Among the classical “big five” mass extinction episodes, the end-Permian mass extinction exhibits temperate preference of extinctions, whereas the Late Devonian and end-Triassic selectively hit tropical genera. Simple links between the inferred direction of climate change and LES are idiosyncratic, both during crisis and background intervals. More complex models, including sampling patterns and changes in the latitudinal distribution of continental shelf area, show tropical LES to be generally associated with raised tropical heat and temperate LES with global cold temperatures. With implications for the future, our paper demonstrates the consistency of high tropical temperatures, habitat loss, and the capacity of both to interact in generating geographic patterns in extinctions.
Deep-sea ostracod faunal dynamics in a marginal sea: biotic response to oxygen variability and mid-Pleistocene global changes
Authors: Huang Huai-Hsuan May , Yasuhara Moriaki , Iwatani Hokuto , Yamaguchi Tatsuhiko , Yamada Katsura , Mamo Briony 
Published: November 2018

AbstractDeep-sea benthic ostracod assemblages covering the last 2 Myr were investigated in Integrated Ocean Drilling Program Site U1426 (at 903 m water depth) in the southern Sea of Japan. Results show that (1) orbital-scale faunal variability has been influenced by eustatic sea-level fluctuations and oxygen variability and (2) secular-scale faunal transitions are likely associated with the mid-Brunhes event (MBE, ~0.43 Ma) and the onset of the Tsushima Warm Current (TWC, ~1.7 Ma).Krithe,Robertsonites, andAcanthocythereisare the three most abundant genera throughout the core, accounting for 78.5% of total specimens. Multiple-regression tree analysis indicated that the TWC, the MBE, and oxygen content are the significant controlling factors of ostracod dominance. Changes in assemblages exhibit decline and recovery patterns corresponding to orbital-scale cyclicity of sea-level changes. In the Sea of Japan marginal ocean setting, this cyclicity shows a close relationship with bottom-water oxygen variability since the onset of the TWC influx. The MBE amplified the influence of the TWC and oxygen variability to the deep-sea ecosystem through larger sea-level fluctuations.Acanthocythereis dunelmensis, a circumpolar species, dominates before the TWC onset. After the TWC onset and during the mid-Pleistocene transition (MPT, ~1.2–0.7 Ma)Krithespp., known for their low-oxygen tolerance, substantially increase under moderate oxygen depletion. At the end of the MPT,Krithedominance diminishes and is replaced byRobertsonites hanaiiandPropontocyprisspp. after the MBE. The post-MBE assemblage, characterized byR. hanaii, suggests a slightly warmer environment under the development of the TWC. In addition, the post-MBE high-amplitude climate system may have caused the increased abundance of active-swimmingPropontocyprisspp. due to their superior migration ability. Benthic ecosystems in marginal seas are sensitive and vulnerable to both short- and long-term climatic changes, and the MBE is suggested to be a global biotic event affecting benthic ecosystems substantially.
Toward an inner connection of SNe Ic, SLSNe Ic, XRF connected SNe, SNe Ic-BL, and GRB connected SNe
Authors: Zou Yuan-Chuan , Cheng K. S. 
Published: November 2018

AbstractType Ic supernovae can be classified as normal supernovae Ic, type Ic super-luminous supernovae, X-ray flash-connected supernovae, broad-line supernovae Ic, and gamma-ray burst-connected supernovae. Here we suggest an inner connection for all kinds of supernovae Ic which is based on whether a pair of jets are successfully launched: a normal supernovae Ic is a normal core collapsar without jets launched; a gamma-ray burst-associated supernovae Ic is a core collapsar with relativistic jets launched and successfully breaking out the envelope of the progenitor; an X-ray flash-associated supernovae Ic is a core collapsar with jets launched but can only develop a relativistic shock breakout; a broad-line supernovae Ic is an off-axis gamma-ray burst or an X-ray flash-associated supernova; and a type Ic super-luminous supernovae is close to the X-ray flash-connected supernovae Ic, but the shock breakout is not relativistic and most of the jet energy is deposited into the supernova component. Based on the luminosity-distance diagram, we derived the luminosity function of all different types of supernovae Ic as a whole. We also show that the normal supernovae Ic and gamma-ray burst-connected supernovae Ic have similar accumulative distributions.
Detrital Sr–Nd isotopes, sediment provenances and depositional processes in the Laxmi Basin of the Arabian Sea during the last 800 ka
Authors: Khim Boo-Keun , Horikawa Keiji , Asahara Yoshihiro , Kim Ji-Eun , Ikehara Minoru 
Published: November 2018

Abstract87Sr/86Sr ratios and εNd values of detrital particles at International Ocean Discovery Program (IODP) Site U1456 in the Laxmi Basin of the Arabian Sea were measured to trace changes in sediment provenance over glacial–interglacial cycles. Based on the correlation of planktonic foraminiferal (Globigerinoides ruber) δ18O fluctuations with the LR04 stack of benthic foraminifera δ18O values, combined with shipboard biostratigraphic and palaeomagnetic data, the studied interval spans ∼1.2 Ma. Over the past 800 ka, 87Sr/86Sr values ranged from 0.711 to 0.726 while εNd values ranged between −12.5 and −7.3 in the detrital particles. By comparing 87Sr/86Sr ratios and εNd values of the possible sources of river sediments with our data, we found that sediments in the Laxmi Basin were influenced to various degrees by proportions of at least three sediment sources (i.e. Tapi River, Narmada River and Indus River). The Indus River might be a more important contributor to glacial sediments. Although 87Sr/86Sr ratios and εNd values varied quasi-cyclically, this pattern did not correspond precisely to the glacial–interglacial cycles. In particular, low-magnetic-susceptibility (low-MS) intervals coinciding with pelagic carbonates were characterized by low 87Sr/86Sr ratios and high εNd values, whereas high-MS intervals matching turbidite deposits showed high 87Sr/86Sr ratios and low εNd values. Thus, this study reveals that differences in the depositional processes between glacial and interglacial periods, governed by changes in sea level and monsoon activity, are an important factor in deciding 87Sr/86Sr ratios and εNd values of the detrital fraction in the Indus Fan of the Arabian Sea.