bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical clinical picture of waldenström’s macroglobulinemia: a difficult path to diagnosis
Authors: Makhnyr’ E. F. , Shostak N. A. , Inasaridze N. O. , Chernaya E. V. 
Published: August 2019

Objective.To describe the difficulties of diagnosis of Waldenström macroglobulinemia in a patient with atypical clinical picture.Materials and methods.Patient K., 57 years old, came in outpatient department with complaints of unilateral increase in submandibular lymph nodes on the right, discomfort in the nasopharynx, cough without sputum, increased fatigue. During the examination she was consulted by: an infectious disease specialist, otolaryngologist, surgeon, dentist, phthisiologist, hematologist and oncologist consulted her. To confirm the diagnosis conducted diagnostic activities: dynamic assessment of laboratory parameters, examination program cancer search (including multislice computed tomography and magnetic resonance imaging of various areas), with the exception of tuberculosis, monogenically study proteins in the blood and urine tests, biopsy of the ileum, immunohistochemistry trepanobiopsy.Results.During the 4‑year examination in the patient’s blood, an M-gradient in the gamma zone was detected, monoclonal immunoglobulin М-κ 19.3 g / l, Bens-Jones-κ protein in urine (daily proteinuria 0.45 g) was detected during immunofixation. In the myelogram at the light-optical level, the number of cell elements was significantly reduced with a pronounced lymphoid proliferation of 40 %, the granulocytic series and erythropoiesis were relatively narrowed, and plasma cells 6 %. Immunomorphological picture trepanobiopsy our patient based on the data of laboratory methods of research corresponds to the defeat of the bone marrow in Waldenström’s disease-κ, secretion of M-paraprotein. An important feature that allowed to go on the right path of diagnosis was almost pathognomonic for tumor lymphoproliferation, detection of Bens-Jones protein in the urine, which was absent in the onset of the disease.Conclusion.This clinical case is interesting not only by the complexity of the diagnosis of macroglobulinemia of Waldenström in General, but also by the atypical, erased clinical disease in our patient.
Grant Funding for Research and Development Characteristics through the Analysis of Law Enforcement Practice of the EU Court
Authors: Slepak V. Yu. , Pozhilova N. A. 
Published: August 2019

Evaluation of the effectiveness of legal regulation is impossible without considering the existing law enforcement, especially court, practice. The EU Court is a landmark institution of the European Union in the field of interpretation of rules of law. Therefore, the presence of a certain number of precedents in its practice, some of which may be the cornerstones not only in this field, but also in others, is of serious scientific and practical interest.The analysis of the facts of real court cases, as well as questions of the interpretation of rules of law, allow us to consider a whole stratum of seemingly completely non-obvious problems (including legal gaps) with a view to eliminating them.
A Note on Fuzzy Soft Ditopological Spaces
Authors: DİZMAN Tuğba Han 
Published: August 2019

In this study, we define fuzzy soft ditopological spaces as the generalization of soft ditopological spaces defined by Simsekler et. al. (2016). Fuzzy soft ditopological space is a combination of fuzzy soft topological and fuzzy soft cotopological spaces which are defined by two independent structures fuzzy soft open and fuzzy soft closed sets. Also we give fuzzy soft -continuity in fuzzy soft topology , fuzzy soft -continuity in fuzzy soft cotopology and by using these two types of continuity we finally define the fuzzy soft continuity in a fuzzy soft ditopology.
THE MEDIATING ROLE OF SUPPLIER NETWORK, THE MODERATING ROLE OF FLEXIBLE RESOURCES IN THE RELATIONSHIP BETWEEN LEAN MANUFACTURING PRACTICES AND THE ORGANIZATIONAL PERFORMANCE
Authors: Saengchai Sakapas , Jermsittiparsert Kittisak 
Published: August 2019

Purpose: Given the internationalization of business today, it illustrates the importance of companies looking for overseas market opportunities for the capture of and sustainability of competitive advantage. Following the success of companies from newly developed nations such as the Far East Asian nations of the Republic of Korea and the Republic of China, Taiwan and South East Asian countries such as Singapore, emerging economies are shifting to external sector growth through export industries from the internal sector growth of import substitutes industries. Thus the current study is interested in exploring the nexus between supply chain integration, export marketing strategies and export performance of Indonesian manufacturing firms.
Methodology: Employing the survey-based methodology, the SEM-PLS technique is used to test the hypothesized relationships. So, the current study has used SEM-PLS as a statistical tool to answer the research questions raised in this study and research objectives envisaged in the current study.
Results: The findings of the study have provided support to the theoretical foundation and proposed hypothesis of the current study. Current study will be helpful for policymakers and practitioners in understanding the issues related to supply chain risk, supply chain integration and supply chain agility. In the author's knowledge this is among very few pioneering studies on this issue.
THE MEDIATING ROLE OF SUPPLY CHAIN MANAGEMENT PRACTICES IN THE RELATIONSHIP BETWEEN MANUFACTURING FLEXIBILITY AND MANUFACTURING PERFORMANCE
Authors: Chetthamrongchai Paitoon , Jermsittiparsert Kittisak 
Published: August 2019

Purpose: The current study is interested in exploring the nexus between manufacturing flexibility supply chain practices and manufacturing performance of Indonesian manufacturing firms. Multidimensionality of manufacturing flexibility within the function of manufacturing is generally accepted by past researchers and its importance honoured.
Methodology: Employing the survey-based methodology, the SEM-PLS technique is used to test the hypothesized relationships. So, the current study has used SEM-PLS as a statistical tool to answer the research questions raised in this study and research objectives envisaged in the current study.
Results: The complexity of manufacturing flexibility has made this concept difficult to comprehend yet delimit. To date, agreement on how to practice this concept has not yet been resolved. The findings of the study have provided support to the theoretical foundation and proposed hypothesis of the current study. Current study will be helpful for policymakers and practitioners in understanding the issues related to supply chain risk, supply chain integration and supply chain agility. In the author's knowledge this is among very few pioneering studies on this issue.
Direito constitucional de recorrer e a judicialização da ineficiência empresarial
Authors: Falcão Joaquim , Hartmann Ivar 
Published: August 2019

Resumo: A judicialização das questões consumeristas atinge o Supremo Tribunal Federal por via dos juizados especiais há vários anos. Recentemente uma empresa do ramo de telefonia, a Oi, destacou-se pelo volume desproporcional de processos que levou ao tribunal. Ao analisar o perfil da litigância de direito do consumidor da Oi no Supremo, identificamos que a empresa envia o dobro de processos do segundo colocado no ranking de maiores litigantes, apesar de ter taxa de sucesso menor do que 0,07%. No contexto da necessidade de adequada proteção dos direitos do consumidor, esse comportamento pode ser caracterizado como bullying processual e demanda novas atitudes por parte dos órgãos reguladores e do próprio Supremo.Palavras-chave: Direito do consumidor. Judicialização. Supremo Tribunal Federal. Abstract: The consumer rights lawsuits have reached the Brazilian Supreme Court through small claims courts for years. Recently, one phone company, Oi, stood out for the disproportional number of appeals it took to the court. We found that Oi brought double the number of appeals of the second most frequent appellant in consumer rights at the Supreme Court, even though Oi’s success rate is lower than 0,07%. In the context of appropriate consumer rights protection, this behavior can be characterized as lawsuit bullying and calls for a new attitude by the regulating agencies and the Supreme Court itself.Keywords: Consumer rights. Lawsuits. Brazilian Supreme Court.
The role of the university in terms of realisation of freedom of teaching and freedom of scientific research – polish case
Authors: Syryt Aleksandra 
Published: August 2019

Abstract: The terms "university", "teaching" and "research" are closely related. The reason for the establishment of a community of learners and students were, on the one hand, the formation of man, and on the other the search for the truth about man, life, society and the world. In the face of technological development and access to information, including the development of legislation that allows the individual, without going through formal institutions, data acquisition, the question arises whether the university is needed, and if so, what is its role in realizing the right to education and freedom of scientific research. Implementation of freedom of scientific research and freedom of teaching in times of universal information access and modern technology can do without the university. However, this is university that can benefit from innovative research methods and teaching remains the most important forum for the exchange of ideas and the search for truth and knowledge transfer, vocational skills and social attitudes.Keywords: Right to education. Freedom of scientific research. Constitution. Cultural rights. Freedom of teaching. Resumo: Os termos "universidade", "ensino" e "pesquisa" estão intimamente relacionados. A razão para o estabelecimento de uma comunidade de alunos e estudantes foram, por um lado, a formação do homem, e por outro a busca da verdade sobre o homem, a vida, a sociedade e o mundo. Em face de desenvolvimento tecnológico e do acesso à informação, incluindo o desenvolvimento de uma legislação que permite que o indivíduo, sem passar por instituições formais, tenha acesso a dados e a informações, gera a questão de saber se a universidade é necessária, e em caso afirmativo, qual é o seu papel na realização dos direitos à educação e à liberdade de pesquisa científica. A implementação da liberdade de investigação científica e liberdade de ensino em tempos de acesso à informação universal e tecnologia avançada pode se realizar sem a universidade. No entanto, a universidade pode se beneficiar de métodos inovadores de pesquisa e de ensino e continuar a ser o mais importante fórum para a troca de ideias ea busca da verdade e da transferência de conhecimentos, competências profissionais e as atitudes sociais.Palavras-chave: Direito à Educação. Liberdade de Pesquisa Científica. Constituição. Direitos Culturais. Liberdade de Ensino.
FORMAÇÃO DOCENTE E PEDAGOGIA: VISÃO DE DISCENTES SOBRE O CURSO
Authors: Rolim Nozângela Maria , Castro Gislaine Müller de , Spagnolo Carla 
Published: August 2019

Este estudo apresenta a visão de estudantes do curso de Pedagogia, do 4º ao 10º período, do Centro de Formação de Professores/CFP, da cidade de Cajazeiras/PB, Campus pertencente à Universidade Federal de Campina Grande/UFCG. O objetivo geral foi compreender a percepção dessas alunas, a partir da realidade de cada uma. A pesquisa, de cunho qualitativo, levou em consideração o que elas pensam, sentem, ouvem, vêm, falam, fazem, suas dores e necessidades dentro e fora da universidade. Esse trabalho foi de extrema relevância, pois proporcionou momentos de escuta das estudantes, como pessoas que enfrentam várias dificuldades para estar na sala de aula, tais como: falta de apoio dos colegas devido o desprestígio econômico da docência. Apesar da satisfação demonstrada pelas alunas sobre o curso e a universidade que frequentam, bem como as perspectivas positivas quanto a profissão, sentem-se desvalorizadas mediante falas e opiniões de colegas e familiares.Palavras-chave: Estudantes; Educação Superior; Realidade; Perspectivas.
Biotechnological bases of the development of cloned pig embryos
Authors: Lopukhov A. V. , Singina G. N. , Zinovieva N. A. 
Published: August 2019

The term ‘clone’ in animal biotechnology refers to an organism derived from non-sexual reproduction, which is both a direct offspring and a genetic copy of the parent organism. To date, the pig appears to be the most interesting object in cloning research. Somatic cell nuclear transfer in pigs has a wide range of potential applications in various fields of human scientific and economic activities. However, the efficiency of producing cloned embryos in swine is still lower than that of other livestock species, in particular horses and cattle. Somatic cell nuclear transfer is a technically complex multi-stage technology, at each stage of which the pig oocytes, which are more susceptible to changes of surrounding conditions, are affected by various factors (mechanical, physical, chemical). At the stage of oocyte maturation, changes in the cell ultrastructures of the ooplasm occur, which play an important role in the subsequent nuclear reprogramming of the transferred donor cell. Before transfer to the oocyte donor somatic cells are synchronized in the G0/G1 stage of the cell cycle to ensure the normal ploidy of the cloned embryo. When removing the nucleus of pig oocytes maturated in vitro, it is necessary to pay attention to the problem of preserving the viability of cells, which were devoid of their own nuclear material. To perform the reconstruction, a somatic cell is placed, using micro-tools, in the perivitelline space, where the first polar body was previously located, or in the cytoplasm of an enucleated oocyte. The method of manual cloning involves the removal of the oocyte nucleus with subsequent fusion with the donor cell without the use of micromanipulation techniques. The increased sensitivity of oocytes to the environmental conditions causes special requirements for the choice of the system for in vitro culture of cloned pig embryos. In this work, we have reviewed the modern methods used for the production of cloned embryos and identified the technological issues that prevent improving the efficiency of somatic cloning of pigs.
Characteristics of the gene pool of spring wheat (<i>Triticum aestivum</i> L.) for resistance to loose smut in the forest-steppe of Western Siberia
Authors: Orlova E. A. , Baechtold N. P. 
Published: August 2019

Among the many diseases of spring wheat caused by pathogenic fungi, loose smut Ustilago tritici (Pers.) Jens. remains to be a dangerous disease with a wide range of distribution. In fields where there is no control over the emergence and spread of the disease, the yield reduction can be up to 10 %, and in the case of highly susceptible varieties, up to 40–50 %. Taking into account the increasing cost of seed protectants and their environmental damage, the cultivation of varieties resistant to loose smut is still the most affordable way to protect plants, reducing the pesticide load on agrocenoses. The crucial point in breeding for resistance is the use of resistant varieties as parental forms. The aim of our research was to isolate samples of spring wheat that are immune to loose smut against the background of artificial infection of plants with a population specific to the West Siberian region. The article presents the results of long-lasting studies of 350 genotypes of spring wheat of different ecological and geographical origin for resistance to disease. Physiological specialization of races was carried out on the basis of a differentiating set consisting of six varieties of soft wheat and three varieties of durum spring wheat. The obtained results in combination with literature data reveal changes in the racial composition of the pathogen population over the past 30–35 years. Varieties of foreign and domestic selection resistant to the West Siberian population of loose smut have been identified. Based on the analysis of pedigree samples, highly and practically resistant to loose smut, we concluded that in breeding for immunity to U. tritici, the same sources of resistance genes are most often used. Among the gene pool of spring wheat of foreign selection, the largest number of genotypes resistant to loose smut is assigned to the countries of the North American geographical zone (USA, Canada, Mexico). These are largely samples containing Ut1 genes, genes from spring wheat ‘Thatcher’ and its sister line ‘DC II-21-44’. Resistance genes in Russian wheat varieties can be traced from cultivars Beloturka, Poltavka, Selivanovsky Hare (using Saratovskaya 29 and its derivatives), and genes from wheatgrass lines AGIS 1 and Grecum 114.
Association of polymorphism <i>TP53</i> Arg72Pro with radon-induced lung cancer in the Kazakh population
Authors: Bulgakova O. , Kussainova A. , Kakabayev A. , Kausbekova А. , Bersimbaev R. 
Published: August 2019

Lung cancer is a problem of great concern and one of the commonest cancer diseases worldwide and in the Republic of Kazakhstan in particular. Radon exposure is classified as the second most important cause of lung cancer. According to the experts, the contribution of natural sources to the average annual radiation dose of the Kazakh population currently stands at 80 %, including 50 % from radon. However, the effect of radon on human health in the Republic of Kazakhstan is almost unknown. The tumor suppressor gene TP53 is a key mediator of the DNA damage response cascade following cell exposure to ionizing radiation. The common polymorphism TP53 Arg72Pro (rs1042522) is a risk factor for lung cancer in the Asian population, but until now no genetic association studies have been done in the Kazakh population. No information on the synergistic carcinogenic effect of radon exposure and polymorphism TP53 Arg72Pro (rs1042522) is available either. This paper presents the results of the study of association between alteration in the TP53 gene and radon-induced lung cancer risk in the Kazakh population. Genetic association was assessed in a case-control study including 44 radon-exposed patients with lung cancer, 41 patients with lung cancer without radon exposure and 42 age/sex-matched healthy controls. We found that polymorphism TP53 Arg72Pro (rs1042522) was associated with lung cancer risk in the Kazakh population (OR = 6.95, 95 % CI = 2.41–20.05). Individuals with the Arg72Pro genotype also showed a significantly higher risk of radon-induced lung cancer (OR = 8.6, 95 % CI = 2.6–28.59).
Prediction of some peroxidase functions in <i>Arabidopsis thaliana</i> L. by bioinformatic search
Authors: Tugbaeva A. S. , Ermoshin A. A. , Kiseleva I. S. 
Published: August 2019

Peroxidases of class III are common in various organisms. They are involved in lignin biosynthesis and plant protection against stressors. Peroxidases are presented in many isoforms, whose role is not always clear. The aim of this study is to analyze the amino acid sequences of reference peroxidases with known functions and peroxidases from Arabidopsis thaliana L. whose functions are unknown and to consider their putative roles in lignin biosynthesis. The structural and functional organization of peroxidases was analyzed by bioinformatical methods applied to open Internet sources. Seven reference peroxidases were chosen from four plant species: Zinnia sp., Armoracia rusticana P.G. Gaertn., Lycopersicon esculentum L. и Populus alba L. Twenty-four amino acid sequences of homologous peroxidases from A. thaliana were selected for the analyses with the BLAST service. Their molecular weights and isoelectric points were calculated. Multiple alignments of amino acid sequences and phylogenetic analysis were done. Sites of binding to monolignol substrates were identified in seven peroxidases from A. thaliana, and the enzymes were assigned to the groups of Sor G-peroxidases. Amino acid replacements in the primary structures of peroxidases were analyzed. Peroxidases from A. thaliana were clustered with reference peroxidases. They formed six clusters on the phylogenetic tree, three of which contained only A. thaliana peroxidases. Peroxidases within each cluster had similar molecular weights and isoelectric points, common localization of expression, and similar functions. Thus, the use of bioinformatics, databases, and published data bring us to assumptions as to the functions of several A. thaliana class III peroxidases. AtPrx39 peroxidase was shown to be affine to sinapyl alcohol; AtPrx54, to p-coumaryl and coniferyl alcohols. They are likely to participate in lignin biosynthesis.
PERILAKU TENTANG CUCI TANGAN PAKAI SABUN DI MADRASAH IBTIDAIYAH TASWIRUL AFKAR
Authors: Trijayanti Dewa Ayu Komang Lisna 
Published: August 2019

Background: School is one of the important institution to implementing health promotion program. The problem that need to be noticed is low awareness to wash hands with running water and soap among students. Purpose: The aim of this research is to describe knowledge, attitudes, practice, facility availability, and the teacher’s role to support handwashing with soap (HWS) habit among students at Madrasah Ibtidaiyah (MI) Taswirul Afkar Surabaya.Methods: This study used observational descriptive method. The population were students in 4th until 6th grade. Results: Results of the study showed that the majority of students (49.1%) had good knowledge. Regarding the attitudes, the majority of students (66.7%) had positive attitudes and most of them (78.4%) had good practices on handwashing with soap. The majority of respondents (56.8%) get support from teachers such as counseling. The teachers was not always controlling the facility availability of handwashing (94.1%) and carrying out supervision handwashing with soap practices among students (76.5%). Based on observations, it is found that washbasin is only available in the schoolyard and four bathroom rooms. Conclusion: Student’s knowledge, attitude, and Practice about handwashing with soap in a good category. There is counseling from teachers and there is no control on handwashing facilities.
Does of market attractiveness increasing tourism visiting intention through destination image in rural tourism?
Authors: Yacob Syahmardi , Erida Erida 
Published: August 2019

The study aims to examine the influence destination image have on tourist visiting intention in the village of Lumpur located at Gunung Raya sub-district, Kerinci Regency, Jambi Province, Indonesia. Similarly, it is also to examine how much the market attractiveness impacts the destination image of rural tourism. Additionally, it set out to also assess the extent to which the support of market attractiveness influences tourist visiting intention through the destination image of the village. This study used a survey method with descriptive and quantitative analysis, and the analytical tool employed is Smart PLS version 3.0 tools. One hundred forty respondents, comprising of both local and foreign tourists, were understudied for the analysis and observations made. The findings showed that market attractiveness has a direct effect on the interests of visitors. Similarly, market attractiveness was established to have a direct impact on tourist’s image. Meanwhile, the destination image also has a direct and significant influence on tourist visiting intention. In conclusion, it was ascertained that the destination image has a substantial effect on the tourist visiting intention, although it has a smaller coefficient of direct influence.