bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feedback inhibition and its control in an insect olfactory circuit
Authors: Ray Subhasis , Aldworth Zane N. , Stopfer Mark A. 
Published: May 2019

AbstractInhibitory neurons play critical roles in regulating and shaping olfactory responses in vertebrates and invertebrates. In insects, these roles are performed by relatively few neurons, which can be interrogated efficiently, revealing fundamental principles of olfactory coding. Here, with electrophysiological recordings from the locust and a large-scale biophysical model, we analyzed the properties and functions of GGN, a unique giant GABAergic neuron that plays a central role in structuring olfactory codes in the locust mushroom body. Analysis of our in vivo recordings and simulations of our model of the olfactory network suggests that GGN extends the dynamic range of KCs, and leads us to predict the existence of a yet undiscovered olfactory pathway. Our analysis of GGN’s intrinsic properties, inputs, and outputs, in vivo and in silico, reveals basic new features of this critical neuron and the olfactory network that surrounds it.
Prevalence, awareness and control of hypertension in Malaysia 1980 – 2017: A Systematic Review and Meta-Analysis
Authors: Chow Zhen Yee , Jun Soo Man , Ching Siew Mooi , Tan Chun Han , Lee Kai Wei , Devaraj Navin Kumar , Syahida Hani , Ramachandran Vasudevan , Hoo Fan Kee , Cheong Ai Theng , Chia Yook Chin 
Published: May 2019

AbstractBackgroundHypertension is a common public health problem worldwide and is a well-known risk factor for increased risk of cardiovascular diseases, contributing to high morbidity and mortality. However, there is no systematic review and meta-analysis that has been done in a multi-ethnic population like Malaysia. This systematic review aims to determine the trend in prevalence, awareness and control of hypertension in Malaysia.MethodsSystematic searches were conducted in PubMed, Scopus, Ovid, Cumulative Index to Nursing and Allied Health Literature, Malaysian Medical Repository and Malaysia Citation Index published between 1980 and 2017. All original articles in English were included. Studies included were those on adults aged 18 years and above. Studies of prevalence in children and adolescents and pregnancy related hypertension were excluded. Two authors independently reviewed the studies, carried out data extraction and performed quality assessment. Heterogeneity between studies and publication bias was assessed and effect size was pooled by the random effect model.ResultsFifty-six studies with a total of 241,796 subjects were included. The prevalence of hypertension throughout Malaysia varied (I2= 99.3%). The overall pooled prevalence of hypertension over the past 4 decades was 28.2% in adults aged 18 years and older (95% CI: 26.1 – 33.3) and the prevalence in those 30 years and older was 40.0% (95% CI: 35.3-44.8).For subgroup analysis, the prevalence of hypertension in male aged 18 and above was 31.4% (95% CI: 26.5 - 36.2) and 27.8% in female (95% CI: 20.7 – 34.9). The prevalence of hypertension among the ethnic groups aged 18 years and above were 37.3% in Malays (95% CI: 32.9 – 41.7); 36.4% in Chinese (95% CI 31.6 - 41.2) and 34.8% in Indians (95% CI: 31.2-38.4). The prevalence of hypertension was the lowest in the 1980s (16.2%, 95% CI: 13.4-19.0%), increases up to 36.8% in the 1990s (95% CI: 6.1-67.5), then came down to 28.7% (95% CI: 21.7-35.8) in the 2000s and 29.2% (95% CI: 24.0-34.4) in the 2010s. The prevalence of awareness was 38.7% (95% CI: 31.7 – 45.8) whereas the control of hypertension of those on treatment was 33.3% (95% CI: 28.4 – 38.2).ConclusionThree in 10 adults aged 18 years old and above have hypertension, whereas four in 10 adults aged 30 years old and above have hypertension. Four out of 10 are aware of their hypertension status and only one-third of them who were under treatment achieved control of their hypertension. Concerted efforts by policymakers and healthcare professionals to improve the awareness and control of hypertension should be of high priority.
Variant Analysis Pipeline for Accurate Detection of Genomic Variants from Transcriptome Sequencing Data
Authors: Adetunji Modupeore O. , Schmidt Carl J. , Lamont Susan J. , Abasht Behnam 
Published: May 2019

AbstractThe wealth of information deliverable from transcriptome sequencing (RNA-seq) is significant, however current applications for variant detection still remain a challenge due to the complexity of the transcriptome. Given the ability of RNA-seq to reveal active regions of the genome, detection of RNA-seq SNPs can prove valuable in understanding the phenotypic diversity between populations. Thus, we present a novel computational workflow named VAP (Variant Analysis Pipeline) that takes advantage of multiple RNA-seq splice aware aligners to call SNPs in non-human models using RNA-seq data only. We applied VAP to RNA-seq from a highly inbred chicken line and achieved >97% precision and >99% sensitivity when compared with the matching whole genome sequencing (WGS) data. Over 65% of WGS coding variants were identified from RNA-seq. Further, our results discovered SNPs resulting from post translational modifications, such as RNA editing, which may reveal potentially functional variation that would have otherwise been missed in genomic data. Even with the limitation in detecting variants in expressed regions only, our method proves to be a reliable alternative for SNP identification using RNA-seq data.
Maternal biomarker patterns for metabolism and inflammation in pregnancy are influenced by multiple micronutrient supplementation and associated with childrens’s biomarker patterns and nutritional status at 9-12 years of age in Lombok, Indonesia
Authors: Priliani Lidwina , Oktavianthi Sukma , Prado Elizabeth L. , Malik Safarina G. , Shankar Anuraj H. 
Published: May 2019

AbstractMaternal nutritional status influences fetal development and long-term risk for adult non-communicable diseases. The underlying mechanisms of these long-term effects remain poorly understood. We examined whether maternal biomarkers for metabolism and inflammation during pregnancy were associated with child biomarkers in the Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT, ISRCTN34151616) in Lombok, Indonesia wherein archived blood specimens and relevant data were available from pregnant women and their children 9-12 years after birth. Forty-four mother-child dyads comprising 132 specimens were analyzed by multiplex microbead immunoassays to quantify vitamin D-binding protein (D), adiponectin (A), retinol-binding protein 4 (R), C-reactive protein (C), and leptin (L). Principal component analysis (PCA) revealed distinct variance patterns, i.e. principal components (PC), for baseline pregnancy bp.pc1.D↓A↓R↓ and bp.pc2.C↓L↑; combined follow-up and post-partum dp-pp.pc1.D↑↓A↑R↑↓L↓ and dp-pp.pc2.A↑C↑L↑; and children ch.pc1.D↑R↑C↑ and ch.pc2.D↓A↑L↑. Maternal multiple micronutrient (MMN) supplementation modified the association between baseline maternal bp.pc2.C↓L↑ and post-supplementation maternal dp-pp.pc2.A↓C↑L↑ (p=0.022). Significant associations were found between maternal dp-pp.pc2.A↑C↑L↑ and increased child ‘s ch.pc1.D↑R↑C↑ (p=0.036), and decreased child ‘s BMI z-score (BMIZ) (p=0.022); and between maternal dp-pp.pc1.D↑↓A↑R↑↓L↑ and increased child ‘s BMIZ (p=0.036). Child ‘s ch.pc1.D↑R↑C↑ was associated with decreased birth weight (p=0.036), and increased child’s BMIZ (p=0.002); and ch.pc2.D↓A↑L↑ was associated with increased child’s BMIZ (p=0.005), decreased maternal height (p=0.030) and girls (p=0.002). Elevated adiponectin and leptin pattern in pregnancy was associated with increased C-reactive protein and vitamin A and D binding proteins pattern in children, suggesting biomarkers acting in concert may be more important than single biomarker effects. Patterns in pregnancy proximal to birth were more associated with child status, and child patterns were most frequently associated with child status, particularly child BMI. Although MMN supplementation and certain maternal biomarker patterns have effects on metabolism and inflammation in pregnancy and in the child, nevertheless, nutrition conditions after birth may have a greater impact.
R Functions for Analysis of Continuous Glucose Monitor Data
Authors: Vigers Tim , Chan Christine L. , Snell-Bergeon Janet , Bjornstad Petter , Zeitler Philip S. , Forlenza Gregory , Pyle Laura 
Published: May 2019

AbstractContinuous glucose monitoring (CGM) is an essential part of diabetes care. Real-time CGM data are beneficial to patients for daily glucose management, and aggregate summary statistics of CGM measures are valuable to direct insulin dosing and as a tool for researchers in clinical trials. Yet, the various commercial systems still report CGM data in disparate, non-standard ways. Accordingly, there is a need for a standardized, free, open-source approach to CGM data management and analysis. Functions were developed in the free programming language R to provide a rapid, easy, and consistent methodology for CGM data management and analysis. Summary variables calculated by our package compare well to those generated by various CGM software, and our functions provide a more comprehensive list of summary measures available to clinicians and researchers. Consistent handling of CGM data using our R package may facilitate collaboration between research groups and contribute to a better understanding of free-living glucose patterns.
Role of ethnicity and socio-economic status (SES) in the presentation of retinoblastoma: findings from the UK
Authors: Bourkiza Rabia , Cumberland Phillippa , Abeysekera Hiranya , Parulekar Manoj , Sagoo Mandeep S , Rahi Jugnoo , Reddy M. Ashwin 
Published: May 2019

AbstractPurposeThe aim of this study was to investigate if there was a relationship between ethnicity or socioeconomic status and the presentation of advanced non-familial retinoblastoma in the UK.MethodsA cross sectional study based at the two centres providing retinoblastoma care in the UK. Non-familial cases of retinoblastoma (Rb) presenting between January 2006 and December 2011 were included. Data collected included: age at diagnosis, gender, child’s ethnicity, International Intraocular Retinoblastoma Classification (IIRC) stage with Groups D and E being considered advanced, laterality, treatment, and postcodes. Individual postcode (ZIP code) data was used to obtain the Index of Multiple Deprivation (IMD) score. A postal questionnaire was sent to participants’ parents to collect further, person-level, information on languages spoken and household socioeconomic position. Measures of severity of retinoblastoma also included: requirement for primary enucleation; the use of adjuvant chemotherapy; and mortality.Results189 cases were analyzed. 98 (52%) male and 91 (48%) female. Median age at diagnosis was 16 months [IQR 8 – 34 months]. 153/189 (81%) of cases presented with advanced retinoblastoma; 75 (40%) group E, 78 (41%) group D. 134 (72%) of cases were treated with enucleation.Multivariable analysis showed that older age at presentation was associated with enucleation and bilateral disease was associated with adjuvant chemotherapy. There was some indication that South Asian ethnicity and being in the most deprived IMD quintile were associated with a higher likelihood of presentation with advanced disease, but these estimates did not reach statistical significance.ConclusionsIn this first national UK study of patients with non-familial retinoblastoma, there was no evidence of an association of ethnicity or socio-economic status and the risk of presenting with advanced disease. This may reflect equality in access of health care in the UK. As a result, awareness campaigns should continue.
Transcriptome-wide map of m6A circRNAs identified in hypoxic pulmonary hypertension rat model
Authors: Su Hua , Zhou Lin , Li Na , Wang Guowen , Wu Lingfang , Ma Xiuqing , Ying Kejing , Zhang Ruifeng 
Published: May 2019

AbstractHypoxic pulmonary hypertension (HPH) is a lethal disease. CircRNAs and m6A circRNAs have been reported to be associated with cancer progression, but the expression profiling of m6A circRNAs has not been identified in HPH. This study was to investigate the transcriptome-wide map of m6A circRNAs in HPH. In this study, hypoxia-induced PH rat model was established. Total RNA was extracted and purified from lungs of rats, then circRNAs were detected and annotated by RNA-seq analysis. m6A RNA Immunoprecipitation (MeRIP) was performed following rRNA depletion, and RNA-seq library was constructed. CircRNA–miRNA–mRNA co-expression network was also constructed. In vitro, total m6A was measured. m6A circXpo6 and m6A circTmtc3 were detected in pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells (PAECs) exposed to 21% O2 and 1% O2 for 48 h, respectively. m6A abundance in 166 circRNAs was significantly upregulated and m6A abundance in 191 circRNAs was significantly downregulated in lungs of HPH rats. m6A abundance in circRNAs was significantly reduced in hypoxia in vitro. m6A circRNAs were mainly derived from single exons of protein-coding genes. m6A influenced the circRNA–miRNA–mRNA co-expression network in hypoxia. m6A circXpo6 and m6A circTmtc3 were downregulated in hypoxia. In general, our study firstly identified the transcriptome-wide map of m6A circRNAs in HPH. m6A level in circRNAs was decreased in lungs of HPH rats and in PASMCs and PAECs exposed to hypoxia. Downregulated or upregulated m6A level influenced circRNA–miRNA–mRNA co-expression network in HPH. Moreover, we firstly identified two downregulated m6A circRNAs in HPH: circXpo6 and circTmtc3. We suggested that m6A circRNAs may be used as a potential diagnostic marker or therapy target in the future.Author summaryHPH is a disease with great morbidity and mortality. It is often caused by chronic hypoxic lung diseases, such as chronic obstructive pulmonary disease and interstitial lung diseases. It lacks effective therapy methods so far. CircRNAs are a type of non-coding RNAs and can be used as biomarkers because they are differentially enriched in specific cell types or tissues and not easily degraded. m6A is identified as the most universal modification on non-coding RNAs in eukaryotes. CircRNAs can be modified by m6A. m6A circRNAs in HPH is not well understood yet. Here we identify the transcriptome-wide map of m6A circRNAs in HPH. We elucidate that m6A level in circRNAs is decreased in lungs of HPH rats and in PASMCs and PAECs exposed to hypoxia. We find that downregulated or upregulated m6A level influences circRNA– miRNA–mRNA co-expression network in HPH. Moreover, we are the first to identify two downregulated m6A circRNAs in HPH: circXpo6 and circTmtc3. We suggest that m6A circRNAs may be used as a potential diagnostic marker or therapy target in the future.
Product market competition and efficiency of corporate tax management
Authors: Wang Tina 
Published: May 2019

Purpose
The purpose of this paper is to test the economic theory that product market competition should enhance firm performance in the US corporate tax management setting. It identifies one mechanism through which corporate management can improve firm performance. The paper also identifies business conditions that may facility or impede effective corporate tax management.

Design/methodology/approach
The paper tests the relationship between product market competition and corporate tax efficiency using large archival data. The primary data source is COMPUSTAT, which contains annual and quarterly accounting data for US public firms. Other data sources include accounting comparability data generously shared by Professor Vedi.

Findings
The paper finds that firms in competitive industries are more efficient in managing taxes. Specifically, the paper documents that firms in competitive industries exhibit lower effective tax rates than their non-competitive counterparts. Furthermore, the paper finds that the positive link between competition and the efficiency of tax management is much stronger for firms with lower cash flow volatility and for firms with fewer industry investment opportunities. The lack of financial statement comparability may weaken this link.

Research limitations/implications
Tax laws vary greatly from country to country. Readers should interpret the results within the US tax environments.

Practical implications
Results in this paper have implications for multinational corporations that are interested in investing and doing business in the USA.

Originality/value
This paper sheds light on how competition influences firm performance through efficient tax management, a specific mechanism through which competition improves firm performance. To the best of the author’s knowledge, this study provides the first documentation of how product market competition affects tax planning for US publicly traded companies.
Exploring inside the box: a cross-cultural examination of stimuli affecting fast food addiction
Authors: Khalid Hania , Lodhi Rab Nawaz , Mahmood Zahid 
Published: May 2019

Purpose
The purpose of this paper, a cross-cultural study, is twofold: first, to identify personal, social, demographical and marketing facets that imply fast food addiction in Pakistan and America, and second to explore the reasons of reduction in fast food consumption in Pakistan.

Design/methodology/approach
The present study followed an explanatory sequential mixed-methods research design. Both quantitative and qualitative data collection methods were used to obtain supportive results of fast food consumption with the help of defining logical relations between independent and dependent variables. Partial least square based structural equation modeling technique was used to analyze quantitative data. For qualitative data, NVivo 11 was used to explore themes.

Findings
Quantitative findings of Pakistani setting suggested that craving and impulsiveness have a significant relation with addiction and have no mediation effect in both the countries. However, these results contradict with US study. Qualitative findings explored many personal, social, marketing and health factors that have affected fast food market of Pakistan which include low income, price-sensitive market, low quality, poor services, PFA, word of mouth, mood, obesity, environment and cultural influence on the consumption behavior of Pakistani consumers.

Research limitations/implications
This study is restricted to the consumption behavior of fast food only in two countries the USA and Pakistan. Hence, the results of this study cannot be generalized to other countries’ cultural and traditional values. In addition, this study only focuses on personal, social and marketing factors that implicate fast food addiction.

Originality/value
The consumption of fast food was the focus of analysis. Therefore, research adds value to service industry and helps in developing growth and marketing strategies for the fast food industry.
Are high-fit CSR programs always better? The effects of corporate reputation and CSR fit on stakeholder responses
Authors: Kim Yeonsoo , Ferguson Mary Ann 
Published: May 2019

PurposeThe purpose of this paper is to examine how corporate reputation interacts with corporate social responsibility (CSR) fit and affects stakeholders’ skeptical attribution (SA) of CSR motives, as well as their attitudes, supportive communication intent and purchase intent. This study proposes that a high-fit CSR program does not necessarily engender more favorable outcomes, nor does it stimulate SA. The study proposes the effects of CSR fit differ by corporate reputation. For bad-reputation companies, low-fit is anticipated to generate more desirable CSR outcomes than high-fit initiatives.Design/methodology/approachTwo experiments were conducted. The first experiment employed a randomized 2 (CSR fit: high fit vs low fit) × 2 (good reputation vs bad reputation) × 2 (Industry: food retailing and insurance) full factorial design to examine the suggested hypotheses. The second study employed a randomized 2 (CSR fit: high fit vs low fit) × 2 (good reputation vs bad reputation) full factorial design with consumer samples to replicate the conceptual relationships among variables in the first study.FindingsWhile reputation plays a dominant role in influencing stakeholders’ CSR-related responses across both CSR fit situations, a SA partially mediates the relationship between reputation and stakeholder reactions. CSR fit interacts with reputation, and influences the partial mediation process through SA; under a bad reputation condition, low-fit CSR engenders less SA and results in better stakeholder reactions. A similar tendency was found with supportive communication intent and purchase intent. High-fit CSR initiatives by a negative reputation company engendered the weakest supportive intent and purchase intent. For a reputable company, across both CSR fits, respondents displayed generally very positive attitudes toward, greater intent to support, and intent to purchase from the company.Originality/valueThe study findings provide useful and empirically supported logical explanations of why high-fit CSR programs sometimes cause backlash effects, despite the general consensus that such initiatives generate positive outcomes. This study offers an alternative and more relevant perspective to conceptualize the complexity of anticipating CSR outcomes.
Employees’ perceived benefits from participating in CSR activities and implications for increasing employees engagement in CSR
Authors: Koch Carina , Bekmeier-Feuerhahn Sigrid , Bögel Paula Maria , Adam Ulrike 
Published: May 2019

Purpose
The involvement of employees in a company’s corporate social responsibility (CSR program) is one of the key factors for its success. Hence, it is important to understand employees’ reactions to participatory CSR activities. The purpose of this paper is to examine what kinds of benefits employees perceive from participating in CSR, to identify varying levels of participation and to discuss the reciprocal relationship between the perception of benefits and participation.

Design/methodology/approach
Based on semi-structured interviews with employees, the structuring content analysis resulted in a differentiated examination of perceived benefit clusters (classified as functional, emotional and meaning and morality) and in a clustered exploration of varying levels of participation (cognitive and behavioral).

Findings
The findings reveal that employees perceived all three clusters of benefits in relation to no/low, passive, active and enthusiastic levels of participation. The data provide insights into the relationship between perceived benefits and varying levels of participation, with a balanced and differentiated perception of benefits seeming to relate to higher levels of participation. However, employees may also benefit without a behavioral form of participation, for instance, from an improved team spirit.

Originality/value
Due to its methodological approach, this empirical study provides a rich picture of employees’ benefits according to varying levels of participation. The paper contributes to current CSR literature by examining self-oriented benefits, through identifying differing levels of participation, and by discussing their reciprocal relation. These findings contribute to research and practice through the implications for promoting sustainability approaches within companies.