bluuebunny/crossref_metadata_2025_split huggingface dataset:
A conserved nuclear export complex coordinates transcripts for dopaminergic synaptogenesis and neuronal surviva
Authors: Maeder Celine I. , Kim Jae-Ick , Kaganovsky Konstantin , Shen Ao , Li Qin , Li Zhaoyu , Shawn Xu X.Z. , Li Jin Billy , Xiang Yang K. , Ding Jun B. , Shen Kang 
Published: March 2018

SummarySynaptic vesicle and active zone proteins are required for synaptogenesis. The molecular mechanisms for coordinated synthesis of these proteins are not understood. Using forward genetic screens, we identified the conservedTHOnuclear exportComplex (THOC) as master regulator of presynapse development inC.elegansdopaminergic neurons. In THOC mutants, synaptic messenger RNAs are trapped in the nucleus, resulting in dramatic decrease of synaptic protein expression, near complete loss of synapses and compromised dopamine function. cAMP-responsive element binding protein (CREB) interacts with THOC to mark activity-dependent transcripts for efficient nuclear export. Deletion of the THOC subunit Thoc5 in mouse dopaminergic neurons causes severe defects in synapse maintenance and subsequent neuronal death in the Substantia Nigra compacta (SNc). These cellular defects lead to abrogated dopamine release, ataxia and animal death. Together, our results argue that nuclear export mechanisms can select specific mRNAs and be a rate-limiting step for synapse development and neuronal survival.HighlightsDopaminergic presynapses are severely impaired inthocmutant worms and miceTHOC specifically controls the nuclear export of synaptic transcriptsCREB recruits THOC onto activity-dependent synaptic transcripts for efficient exportDopamine neurons in the SNc degenerate upon conditional knock-out ofthoc5
Axons morphometry in the human spinal cord
Authors: Duval Tanguy , Saliani Ariane , Nami Harris , Nanci Antonio , Stikov Nikola , Leblond Hugues , Cohen-Adad Julien 
Published: March 2018

AbstractDue to the technical challenges of large-scale microscopy and analysis, to date only limited knowledge has been made available about axon morphometry (diameter, shape, myelin thickness, density), thereby limiting our understanding of neuronal microstructure and slowing down research on neurodegenerative pathologies. This study addresses this knowledge gap by establishing a state-of-the-art acquisition and analysis framework for mapping axon morphometry, and providing the first comprehensive mapping of axon morphometry in the human spinal cord.We dissected, fixed and stained a human spinal cord with osmium, and used a scanning electron microscope to image the entirety of 24 axial slices, covering C1 to L5 spinal levels. An automatic method based on deep learning was then used to segment each axon and myelin sheath which, producing maps of axon morphometry. These maps were then registered to a standard spinal cord magnetic resonance imaging (MRI) template.Between 500,000 (lumbar) and 1 million (cervical) myelinated axons were segmented at each level of this human spinal cord. Morphometric features show a large disparity between tracts, but remarkable right-left symmetry. Results confirm the modality-based organization of the dorsal column in the human, as been observed in the rat. The generated axon morphometry template is publicly available at https://osf.io/8k7jr/ and could be used as a reference for quantitative MRI studies. The proposed framework for axon morphometry mapping could be extended to other parts of the central or peripheral nervous system.
Does environmental leadership affect market and eco performance? Evidence from Korean franchise firms
Authors: Kim Minseong , Stepchenkova Svetlana 
Published: March 2018

PurposeExternal economic and social forces compel foodservice enterprises to be environmentally friendly, bringing environmental issues to the forefront of managerial policies. Reflecting on this phenomenon, this paper aims to investigate the role that the environmental leadership of the top management at the franchise headquarters and the companies’ environmental orientation play in enhancing the company’s market and eco performances.Design/methodology/approachThe research model was tested based on responses from 196 regional foodservice franchising headquarters in South Korea. Structural equation modeling, namely, confirmatory and path analysis, was the primary method of data analysis in the study.FindingsResults indicate that the top management’s environmental transformational leadership influences the internal and external environmental orientation of a foodservice franchise firm. Also, the two types of environmental orientation improve the market and eco performances of the firm. Finally, two dimensions of environmental orientation, internal and external, act as full mediators of the relationship between environmental transformational leadership and the performance of the firm.Practical implicationsThe positive link between environmental leadership, environmental orientation and market performance seems to indicate that individual franchisees may be receptive to rules and regulations associated with green practices and be willing to incorporate the green business procedures of their franchisor into their day-to-day operations.Originality/valueGiven the lack of empirical research that investigates environmental policies in the foodservice industry in the international context, this study contributes to an understanding of how foodservice franchising firms view the environmental leadership of the company’s top management and its impact on a company’s environmental orientation and market performance.
Enhancing the effect of frontline public employees’ individual ambidexterity on customer value co-creation
Authors: Luu Tuan Trong , Rowley Chris , Dinh Khai Cong 
Published: March 2018

PurposeWhen public employees demonstrate ambidexterity in serving customers, through efficiently providing customers with current public services as well as exploring ways to create more, new public service solutions for customers, they may activate customers’ co-creating value with the public organization. The purpose of this research is to examine the role of public employees’ individual ambidexterity in promoting customer value co-creation. This research also seeks to investigate the levers behind individual ambidexterity, including ambidextrous leadership as an antecedent and public service motivation (PSM) as an enhancer for the leadership effect.Design/methodology/approachPublic employees from public legal service agencies and customer companies they had served have been invited to participate and provide data for this research. The data collated have been analyzed using multilevel structural equation modeling approach.FindingsAmbidextrous leadership was positively associated with frontline public employees’ individual ambidexterity. This positive association was enhanced by PSM among frontline public employees. In turn, frontline public employees’ individual ambidexterity demonstrated a positive link with customer value co-creation through the mediation mechanisms of customer–employee identification and customer–organization identification.Originality/valueThis research extends and marks the convergence between ambidexterity and customer value co-creation research streams.
B2B negotiation tactics in creative sectors
Authors: Sigurdardottir Aldis Gudny , Ujwary-Gil Anna , Candi Marina 
Published: March 2018

PurposeThe purpose of this study is to examine the negotiation tactics used in business-to-business (B2B) negotiations in creative sectors and to shed light on some of the characteristics of creative sectors that might drive these behaviors.Design/methodology/approachThis is a multiple-case study involving interviews with 18 creative sector negotiators engaged in B2B negotiations.FindingsThe findings suggest that negotiators in B2B firms in creative sectors use a variety of negotiation tactics to reach agreement, but that there are some differences compared with other sectors. One group of tactics, not represented in existing taxonomies, is identified and termed closure-seeking tactics, referring to tactics intended to speed up the negotiation process and reach agreement as quickly as possible. The reasons for creative sector negotiators’ choice of closure-seeking tactics might stem from their desire to expedite the start of new projects to enable them to fulfill their creative drive.Research limitations/implicationsIn addition to the identification of group of tactics observed in creative sectors, but not anticipated by existing research, the findings indicate that negotiators in creative sectors seem to lack interest in, and expertise for, negotiating and might be driven more by the desire to get on with the creative process than by concerns over monetary gains when negotiating. This could reflect unique characteristics of creative sectors and the people who work in these sectors.Practical implicationsThis work offers new insights and understanding about tactics used in B2B negotiations in creative sectors. These findings have important implications for both practitioners in creative sectors, who might be too eager to reach closure quickly, and practitioners negotiating with firms in creative sectors, who need to understand the unique characteristics of these firms.Originality/valueThe originality of this work lies in its consideration of tactics used in B2B negotiations in the under-studied context of creative sectors and investigation of the reasons that drive the choice of tactics.
Leadership styles, goal clarity, and project success
Authors: Raziq Muhammad Mustafa , Borini Felipe Mendes , Malik Omer Farooq , Ahmad Mansoor , Shabaz Mehwish 
Published: March 2018

Purpose
The purpose of this paper is to examine the mediating role of goal clarity in the relationship between leadership styles and project success. The paper draws on full-range leadership theory, and contextualizes leadership styles such as transformational leadership style, and transactional leadership style (active management by exception, and contingent reward) to temporary project environment.

Design/methodology/approach
Data are collected (in year 2017) from 248 individuals working in ten large project-based organizations from different sectors, each having multiple units in Pakistan. Respondents comprise functional managers and individuals (who have lead or worked on projects), as well as dedicated project managers.

Findings
Goal clarity partially mediates the relationship between transformational leadership style and project success. However, in case of the transactional leadership style, there is no mediation as transactional leadership style is not associated with goal clarity. Furthermore, contingent reward is positively associated to project success, while active management by exception is negatively associated to project success.

Originality/value
Research suggests that the underlying mechanisms of the relationship between leadership styles (transactional and transformational) and project success are less clear and need to be further explored. This study contributes to literature by answering such calls, and examines possible underlying mechanisms (i.e. goal clarity) in the relationship between leadership styles and project success.
Assessing the shipping in the Northern Sea Route: a qualitative approach
Authors: Tseng Po-Hsing , Pilcher Nick 
Published: March 2018

Purpose
The Northern Sea Route (NSR) could become viable in the near future. If this happens, it will radically reduce sailing times and distances on routes from Asia to Northern Europe. However, although much has been written about the feasibility of the NSR, about the issues involved and about the possible opening of the route, the views of key stakeholders from companies who would potentially benefit from the route have been little explored. The purpose of this paper is to complement the existing literature on the feasibility of and issues related to the NSR by presenting and discussing the results from in-depth qualitative interviews with nine key stakeholders based in Shanghai and Taiwan who have extensive research, knowledge and practical experience of NSR.

Design/methodology/approach
Based on a grounded theory analysis, a total of nine key stakeholders knowledgeable about NSR and the majority with sailing experience of NSR are interviewed, including one government official, two professors, shipping experts in six liner and one bulk shipping companies.

Findings
The authors present interviewees’ thoughts regarding the feasibility of NSR at the current time in terms of practicalities, ships, costs, information and wider issues.

Practical implications
These thoughts show that whilst the potential of NSR is huge in theory, in practice the overall perception of it in terms of current feasibility from a company perspective is one of challenges and unknown issues. Shipping companies can benefit from the authors findings when considering the feasibility of NSR as a shipping route. Ultimately, the picture emerges that without one country, probably Russia, taking the lead on the route, it will remain only a theoretical one.

Originality/value
In-depth interviews with grounded theory are used to investigate current and actual thoughts on NSR. This paper highlights correlations and additions to show a fuller picture of current knowledge and adds views from Shanghai and Taiwan.
Calibration of three-axis magnetometers with alternative iteration looping optimization method
Authors: Li Ting , Zhang Jinsheng , Wang Shicheng , Li Dongyu , Lv Zhifeng , Jiang Jiangjun 
Published: March 2018

Purpose
This study aims to find a novel solution to the calibration of three-axis magnetometers to suppress errors of sensors. The nature of the calibration process is parameter estimation and hence the purpose of the paper is to calculate the error parameters and eliminate sensor errors and obtain the true value of the pure magnetic field.

Design/methodology/approach
The paper puts forward a calibration method using an alternative iteration looping optimization (AILO) to estimate the parameters. The proposed method divided the parameters to be estimated into two parts: a portion less than one and the other greater than one. Parameters with different orders of magnitude are calculated respectively, which let one part to be a known quantity and the other part is derived by the known quantity; the derived quantity is used to calculate the known quantity again, and looping iteration multiple times until the iteration termination condition is satisfied.

Findings
The simulation and experimental results indicate that the calibration accuracy is improved at least by two orders by the proposed method compared to the two-step method and the linear decreasing weight particle swarm optimization (LDW-PSO) algorithm which proves the validity of the proposed method.

Practical implications
The proposed method can improve the calibration accuracy of total magnetic field, which provides a reference to the calibration of three-axis magnetometers.

Originality/value
A calibration method based on the AILO is proposed in this paper, which is used to improve the calibration accuracy of the three-axis magnetometer.
The Conservative Party and the Impact of the 1918 Reform Act
Authors: Ball Stuart 
Published: March 2018

AbstractBefore the First World War, the Conservative Party feared the extension of the suffrage to all adult males, and was divided over even a limited granting of votes to women. However, the patriotic public response to the war moderated these attitudes, and by 1916 the Conservatives were in favour of giving the vote to all servicemen. Although the Conservatives were represented in the Speaker's conference which drew up proposals for electoral reform, when its report was published in January 1917, these were almost entirely opposed by the party organisation. However, the Conservatives came to accept adult male suffrage as the only practicable way of recognizing the servicemen's contribution. During the passage of the electoral reform bill, they successfully amended it in several respects and secured gains from the redistribution of constituencies. This essay assesses the Conservative response to the reform proposals and the impact of the Representation of the People Act 1918 upon the party's fortunes, organisation, and culture. During the following decade, the Conservative Party made substantial efforts to reach the female, younger, and working‐class voters. While it was reassured by electoral success, and especially support from women, there remained concerns about the nature of democracy and demands from the grass roots for a defensive restoration of powers to the house of lords. However, by 1928, giving the vote to women on equal terms of adult citizenship was seen as the inevitable completion of the new electoral system – in which the Conservatives became the most successful party.
The Liberal Party and the Impact of the 1918 Reform Act
Authors: Freeman Gavin 
Published: March 2018

AbstractThis essay challenges the conventional wisdom concerning the impact of the 1918 Reform Act on the Liberal Party. It was not the extension of the franchise or any other feature of the act that led to the downfall of the Liberal Party. Instead, it was the division between Asquith and Lloyd George and the resulting ‘Coupon election’ of 1918 which severely harmed the Liberals, and the provisions of the act only caused difficulties for the Liberal Party in the context of the split. This essay explores the four facets of the 1918 Reform Act (the enlarged franchise, the redistribution of constituencies, the new registration system, and the method of election), and examines how these affected the Liberal Party. The response of the Liberal elite to these changes is found to be wanting, with the leadership of Asquith particularly criticized. It was the failure of the party leaders to engage with the changed circumstances, and particularly the ways in which they viewed the new electorate, that disadvantaged the Liberals. The coincidental timing of the act, when the Liberals were at their most divided for a generation, provides the most persuasive explanation of why they struggled while the Labour and Conservative Parties prospered under the new system.
Consistency of a hybrid block bootstrap for distribution and variance estimation for sample quantiles of weakly dependent sequences
Authors: Kuffner Todd A. , Lee Stephen M. S. , Young G. A. 
Published: March 2018

SummaryConsistency and optimality of block bootstrap schemes for distribution and variance estimation of smooth functionals of dependent data have been thoroughly investigated by Hall, Horowitz & Jing (), among others. However, for nonsmooth functionals, such as quantiles, much less is known. Existing results, due to Sun & Lahiri (), regarding strong consistency for distribution and variance estimation via the moving block bootstrap (MBB) require thatb→∞, whereb=⌊n/ℓ⌋ is the number of resampled blocks to be pasted together to form the bootstrap data series,nis the available sample size, and ℓ is the block length. Here we show that, in fact, weak consistency holds for anybsuch that 1≤b=O(n/ℓ). In other words we show that a hybrid between the subsampling bootstrap (b=1) and MBB is consistent. Empirical results illustrate the performance of hybrid block bootstrap estimators for varying numbers of blocks.
China's Opening up after 40 Years: Standing at a Historic Turning Point
Authors: Ju Jiandong , Yu Xinding 
Published: March 2018

AbstractThis paper comprehensively reviews China's openness since 1978 from three aspects: trade, foreign investment and global production sharing. We point out that the economic development of China is now standing at a historic turning point. Specifically, economic changes in China are discussed from four dimensions: (i) from China being a world assembly line to a world manufacturing powerhouse; (ii) from China being a world capital receiver to a world investor; (iii) from China being a world factory to a world market; and (iv) from the situation of “made in China” to “innovated in China.” At the same time, the global economic system has also reached a turning point. A “North America–Europe–Asia” tri‐polar system has formed, in which the USA, Germany and China, respectively, serve as the regional core economies.
Ecumenism in the 21st Century
Authors: Kobia Samuel 
Published: March 2018

AbstractThis article explores the challenges facing the ecumenical movement at the beginning of the 21st century: global demographic trends and a shift in the centre of gravity of Christianity toward the global South; the need for ecumenical structures and institutions to change in response to new realities; the need to widen the ecumenical fellowship so that Roman Catholics, Pentecostals, and evangelicals who have not played a part in the WCC may participate more fully; the urgency of inter‐religious dialogue; and the need to discover a “spirituality of engagement” in interaction with the world and its people.
Konrad Raiser: The Challenge of Transformation
Authors: Robra Martin 
Published: March 2018

AbstractThis article discusses the role played by Konrad Raiser in the World Council of Churches (WCC), from 1969, when he joined the staff as a study secretary, to his time as general secretary from 1993 to 2003, and especially his role in the conciliar process for Justice, Peace, and the Integrity of Creation. As general secretary, Raiser played a key role in supporting and encouraging the churches' witness for peace and nonviolence, strengthening the fellowship of churches within the WCC through the process to develop a “Common Understanding and Vision” and the Special Commission on Orthodox Participation in the WCC.
Adaptation to hypoxic environments; bearded gobies Sufflogobius bibarbatus in the Benguela upwelling ecosystem
Authors: Salvanes A. G. V. , Gibbons M. J. 
Published: March 2018

The oceans of the world are slowly losing oxygen, in part because of climate change and in part because of anthropogenic eutrophication. This deoxygenation affects marine organisms in species‐specific ways. This paper reviews what is known on how hypoxia tolerant species respond to low dissolved oxygen, using the bearded goby Sufflogobius bibarbatus as a model system. This species is endemic to the Benguela upwelling ecosystem, where, off Namibia, 9000 km2 of the shelf is hypoxic. Here, the species is now considered central to ecosystem functioning and in recent decades it has sustained commercial fisheries. Unlike their predators, S. bibarbatus has strong anti‐predator responses as they can remain alert and escape threats in anoxic and severely hypoxic waters and can cope with sulphide shocks. Populations display diel vertical migration and shuttle between suboxic seabed refugia during the day to more oxygenated waters higher up in the water column at night and whilst they may share the water column with predators they may reduce their predation risk by associating with jellyfish (Aequorea forskalea and Chrysaora fulgida). The spatial distribution of S. bibarbatus varies with changes in available oxygen and populations expand and contract with climate‐induced changes in the distribution of hypoxic waters. This species has an unusual diet and plays an important role in ecosystem functioning. It is a batch‐spawner, with a protracted spawning season. Remarkably, males display alternative reproductive tactics and reproduction can take place at oxygen levels <0·5 ml l−1 dissolved oxygen on the shelf break. Gaps in knowledge are identified and future works are proposed.
Draft Genome Sequence of Mn(II)-Oxidizing Pseudomonas resinovorans Strain MO-1
Authors: Matsushita Shuji , Nakano Michiharu , Aoi Yoshiteru , Kindaichi Tomonori , Ozaki Noriatsu , Ohashi Akiyoshi 
Published: March 2018

ABSTRACT

Pseudomonas resinovorans
strain MO-1, which possesses a high ability to oxidize Mn(II), has been isolated from oligotrophic pond sediment. The draft genome sequence consists of 6,252,942 bp and has a G+C content of 63.4%. Strain MO-1 has 5,694 coding sequences, including 13 putative Mn(II) oxidation genes.