bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacteriophage-resistant industrial fermentation strains: from the cradle to CRISPR/Cas9
Authors: Baltz Richard H 
Published: September 2018

Abstract
Bacteriophage contamination and cell lysis have been recurring issues with some actinomycetes used in the pharmaceutical fermentation industry since the commercialization of streptomycin in the 1940s. In the early years, spontaneous phage-resistant mutants or lysogens were isolated to address the problem. In some cases, multiple phages were isolated from different contaminated fermentors, so strains resistant to multiple phages were isolated to stabilize the fermentation processes. With the advent of recombinant DNA technology, the early scaleup of the Escherichia coli fermentation process for the production of human insulin A and B chains encountered contamination with multiple coliphages. A genetic engineering solution was to clone and express a potent restriction/modification system in the production strains. Very recently, an E. coli fermentation of 1,3-propanediol was contaminated by a coliphage related to T1. CRISPR/Cas9 technology was applied to block future contamination by targeting seven different phage genes for double-strand cleavage. These approaches employing spontaneous mutation, genetic engineering, and synthetic biology can be applied to many current and future microorganisms used in the biotechnology industry.
Penile Sensory Changes After Plaque Incision and Grafting Surgery for Peyronie’s Disease
Authors: Terrier Jean E. , Tal Raanan , Nelson Christian J. , Mulhall John P. 
Published: September 2018

Abstract

Introduction
Plaque incision and grafting (PIG) for Peyronie’s disease (PD) is not devoid of complications such as erectile dysfunction and penile sensory changes.

Aim
To define the rate and chronology of penile sensation loss after PIG surgery and to define predictors of such.

Methods
The study population consisted of patients with PD-associated penile curvature who underwent PIG surgery with at least 6 months of follow-up. Demographics and PD factors were recorded. Patient had preoperative assessment of penile sensation and deformity. Postoperative follow-up occurred at 1 week, 1 month, 6 months, and 1 year after surgery. Neurovascular bundle elevation was conducted with loupe magnification.

Main Outcome Measure
Penile sensation was evaluated with a biothesiometer and graded on a patient-reported visual analog scale (0–10) in which 0 defined a completely numb area and 10 defined perfect sensation. The degree of sensation loss was defined as extensive (any 1 area &gt;5 cm), major (2–5 cm), and minor (≤2 cm). The penile sensation loss distribution was defined as focal (1 site) or diffuse (&gt;1 site).

Results
63 patients were analyzed. Mean age was 56 ± 10 years. Mean duration of PD at the time of PIG was 15 ± 7 (12–38) months. 75% had curvature alone, and 25% had hourglass/indentation deformities. Mean primary curvature was 64˚ ± 28˚. The mean operation duration was 3.5 ± 1.8 hours. 21% had some degree of sensation loss at 1 week, 21% at 1 month, 8% at 6 months, and 3% at 12 months. Only 1 patient (1.5%) at 2 years continued to have extensive sensation loss on the glans and distal shaft with a very elevated sensitivity threshold. Using multivariable analysis, the only predictor of penile sensation loss ≥6 months was a duration of operation &gt;4 hours (odds ratio = 2.1; 95% confidence interval = 1.2–3.0; P &lt; .01).

Clinical Implications
The study highlights the need during patient consent to discuss penile sensation loss. Patients should be informed that rates of penile sensation loss ranges from 2-30% and most patients will have complete resolution of any sensation loss within one year of follow-up.

Strength and Limitations
To our knowledge no other studies have described the chronology and severity of penile sensation following PIG, our study demonstrates the utility of biothesiometry in measuring penile sensation before and after PIG. Number of patients and absence of control group represent a limitation.

Conclusion
Sensation loss is not uncommon after PIG surgery. It decreases in frequency and severity with time with only rare cases occurring &gt;12 months. Longer operations appeared to be more likely associated with sensation loss.
Schlick on the Source of the ‘Great Errors in Philosophy’
Authors: TEXTOR MARK 
Published: September 2018

AbstractMoritz Schlick's work shaped logical empiricism and thereby an important part of philosophy in the first half of the twentieth century. A continuous thread that runs through his work is a philosophical diagnosis of the ‘great errors in philosophy’: philosophers assume that there is intuitive knowledge or knowledge by acquaintance. Yet, acquaintance is not knowledge, but an evaluative attitude. In this paper I will reconstruct Schlick's arguments for this conclusion in the light of his early practical philosophy and his reading of Schopenhauer's The World as Will and Idea. Having the historical roots of Schlick's dichotomy between acquaintance (intuition) and knowledge in view will put us in a position to explore and question its presuppositions.
Bernard Williams on Regarding One's Own Action Purely Externally
Authors: WOJTOWICZ JAKE 
Published: September 2018

AbstractI explore what Bernard Williams means by regarding one's action ‘purely externally, as one might regard anyone else's action’, and how it links to regret and agent-regret. I suggest some ways that we might understand the external view: as a failure to recognize what one has done, in terms of Williams's distinction between intrinsic and extrinsic luck, and as akin to Thomas Nagel's distinction between an internal and external view. I argue that none of these captures what Williams was getting at because they do not allow one to take a view on one's action. I offer two alternative accounts. One turns around what we identify with, the other concerns what we care about. Both accounts capture how I might regret, rather than agent-regret, my own action. I demonstrate that these accounts can explain the relationship between an insurance payout and the external view, and they can explain the agent-relativity of agent-regret.
Advancing the multi-disciplinarity of parasitology within the British Society for Parasitology: studies of host–parasite evolution in an ever-changing world
Authors: Stothard J. R. , Littlewood D. T. J. , Gasser R. B. , Webster B. L. 
Published: September 2018

AbstractThe study of parasites typically crosses into other research disciplines and spans across diverse scales, from molecular- to populational-levels, notwithstanding promoting an understanding of parasites set within evolutionary time. Today, the 2030 Sustainable Development Goals (SDGs) help frame much of contemporary parasitological research, since parasites can be found in all ecosystems, blighting human, animal and plant health. In recognition of the multi-disciplinary nature of parasitological research, the 2017 Autumn Symposium of the British Society for Parasitology was held in London to provide a forum for novel exchange across medical, veterinary and wildlife fields of study. Whilst the meeting was devoted to the topic of parasitism, it sought to foster mutualism, the antithesis perhaps of parasitism, by forging new academic connections and social networks to exchange novel ideas. The meeting also celebrated the longstanding career of Professor David Rollinson, FLS in the award of the International Federation for Tropical Medicine Medal for his efforts spanning 40 years of parasitological research. Indeed, David has done so much to explore and promote the fascinating biology of parasitism, as exemplified by the 15 manuscripts contained within this Special Issue.
AT MASS WITH SIR JAMES: MACMILLAN'SSYMPHONY NO. 4AND LITURGICAL TIME
Authors: Ward Matthew 
Published: September 2018

AbstractSir James MacMillan'sSymphony No. 4is claimed by the composer as an abstract work, but a clear programme is discernible through the use of references to the Roman Catholic Mass. MacMillan uses Gregorian chant, quotations from Robert Carver'sMissa Dum sacrum mysterium(c. 1523) and his ownSt Luke Passion(2015) to create a liturgical form for the symphony. These allusions and their presentation in the symphony can be fruitfully understood in relation to Catholic theologies of time and the Eucharist. When allusions to sonata form are also taken into consideration, the result is a complex interaction between different experiences of time in the symphony's span.
Identification and formation mechanism of the transient ion fragments produced in laser-induced dissociation of 1, 1-diamino-2, 2-dinitroethylene
Authors: Zhang Wei , Bao Lirong , Jiang Kexin , Shi Anran , Shen Ruiqi , Ye Yinghua 
Published: September 2018

AbstractDetailed knowledge of dissociation behavior and dissociation products is necessary to understand the stability, sensitivity, and the reactive mechanism of explosives under laser initiation. A time-of-flight mass spectrometer was utilized to detect the transient products of 1,1-diamino-2,2-dinitroethylene (FOX-7) produced under 532 nm pulse laser ablation, the possible attribution of intermediate ion fragments were confirmed. The laser fluence threshold for detectable fragments is about 3.6 J/cm2. The peak intensities of main ions (CN, CNO/C2H4N, NO2, C2N2O, HCN, C2NH2, etc.) increase with the increasing of laser fluence, and reach the maximum at 11.5 J/cm2. Moreover, time-depend changes of ion intensity indicate that the type and degree of reactions are different in different periods. According to the molecular structure of FOX-7 and the intermediate ions, the laser-induced dissociation mechanisms were proposed to illustrate the cause of the fragments which might throw some light on the laser initiation of FOX-7.
Senior Centres in Canada and the United States: A Scoping Review
Authors: Kadowaki Laura , Mahmood Atiya 
Published: September 2018

RÉSUMÉLes centres pour personnes âgées ont été identifiés comme des points focaux pour la prestation de services pour la population vieillissante, qui est en forte croissance au Canada et aux États-Unis. Malgré ce rôle important des centres pour personnes âgées, peu de recherches leur ont été consacrées. Cet examen de portée a ciblé les études empiriques en langue anglaise portant sur les centres pour personnes âgées qui ont été publiées dans des revues scientifiques depuis 2000. Un total de 58 études ont été repérées (n = 51 pour les études américaines, n = 7 pour les études canadiennes). La majorité de ces articles était centrée sur des thèmes liés à la participation d’individus dans les centres pour personnes âgées, et quelques études seulement traitaient du milieu associé aux centres pour personnes âgées. Ces résultats suggèrent que les recherches futures devraient cibler les avantages de la programmation des centres pour personnes âgées, avec une attention particulière sur les besoins des baby-boomers, sur les facteurs clés liés au financement, aux espaces et au personnel, ainsi que sur les caractéristiques et les rôles des centres pour personnes âgées dans le contexte canadien.
Long-term declines in waterbirds abundance at Lake Junín, Andean Peru
Authors: DINESEN LARS , CHAMORRO ALAN , FJELDSÅ JON , AUCCA CONSTANTINO 
Published: September 2018

SummaryLake Junín is famous for the abundance and diversity of breeding, staging and wintering waterbirds. The lake supports the entire world population of three species or subspecies: Junín GrebePodiceps taczanowskii,Junín RailLaterallus tuerosiand the endemic subspecies of the White-tufted GrebeRollandia rolland morrisoni. Surveys undertaken in the 1930s, 1960s, 1970s and 1980s confirmed the lake’s importance in the Andes, however there has been no recent assessment of its waterbird community. We undertook waterbird counts between 6 and 20 February 2014 from the lakeshore and by boat. Despite using differing survey methods, we nevertheless conclude that the relative abundance of waterbird species has changed dramatically compared to earlier counts. Most notably, the Junín Grebe has experienced a major decline since the 1930s when the species was considered extremely abundant and another native fish-eating species the White-tufted Grebe also appears to have declined. In contrast the Northern Silvery GrebePodiceps juninensis, classified as ‘Near Threatened’, has apparently become more abundant. Numbers of Puna TealSpatula punaand Common GallinuleGallinula galeataseem to have crashed, presumably reflecting the general loss of submerged vegetation. In spite of a major decline in waterbirds overall, the Junín area holds numbers of migratory shorebirds, perhaps as a consequence of local hunting restrictions and awareness campaigns. Lake Junín is a candidate for listing on the Montreux Record under the Ramsar Convention as a wetland showing serious change in ecological character. Management planning should proceed to balance conflicting interests at the lake. Actions to re-establish a clear water column by reducing eutrophication (from settlements in the catchment) as well as sedimentation and heavy metals (from upstream mining) will contribute to improving ecological functions and to secure waterbirds including the endemics.
Dietary patterns associated with hypertension risk among adults in Thailand: 8-year findings from the Thai Cohort Study
Authors: Shi Zumin , Papier Keren , Yiengprugsawan Vasoontara , Kelly Matthew , Seubsman Sam-ang , Sleigh Adrian C 
Published: September 2018

AbstractObjectiveDietary intake is a leading risk factor for hypertension. We aimed to assess longitudinal associations between overall dietary patterns and incident hypertension among adults in Thailand.DesignProspective large Thai Cohort Study (TCS) conducted nationwide from 2005 to 2013. Dietary patterns were identified using factor analysis based on usual intake of fourteen food groups. Multivariable logistic regression assessed associations between dietary patterns and hypertension prevalence and incidence.SettingEmerging hypertension and changing diets in Thailand.SubjectsTCS participants who were normotensive at baseline in 2005.ResultsAmong 36293 participants without hypertension at baseline, 1831 reported incident hypertension (5·1 % incidence) at follow-up. Two dietary patterns were identified: ‘Modern’ and ‘Prudent’. The Modern dietary pattern (high intakes of roasted/smoked foods, instant foods, canned foods, fermented fruits/vegetables, fermented foods, soft drinks, deep-fried foods) was associated with increased incident hypertension (comparing extreme quartiles, OR for incident hypertension=1·51; 95 % CI 1·31, 1·75 in 2013). The Prudent dietary pattern (high intakes of soyabean products, milk, fruits, vegetables) was not associated with incident hypertension in a fully adjusted model. The association between the Modern dietary pattern and hypertension was attenuated by BMI.ConclusionsModern dietary pattern was positively associated with hypertension among Thai adults. BMI had a great impact on the relationship between the Modern dietary pattern and incidence of hypertension. Reduction of Modern diets would be expected to prevent and control hypertension. Such a strategy would be worth testing.
Influence of El Niño‐Southern Oscillation on Global Coastal Flooding
Authors: Muis Sanne , Haigh Ivan D. , Guimarães Nobre Gabriela , Aerts Jeroen C. J. H. , Ward Philip J. 
Published: September 2018

AbstractAnomalous atmosphere‐ocean conditions in the tropical Pacific associated with the El Niño‐Southern Oscillation (ENSO) drive interannual variations in mean and extreme sea levels. Climate change may lead to more frequent extreme ENSO events in the future. Therefore, it is important to enhance our understanding of ENSO's influence on coastal flood impacts. We assessed ENSO's influence on extreme sea levels using a global reanalysis of tides and storm surges. This allows for a full coverage of the global coastline from 1979 to 2014. A mean sea level component is added to account for steric effects. This results in a substantial improvement in the representation of the seasonal and interannual variability. Our results show significant correlations across the Pacific between ENSO and extreme sea levels (expressed as 95th annual percentiles), which is consistent with previous studies based on tide gauge observations. Average anomalies in the annual percentiles over El Niño years compared to neutral years show similar patterns. When examining total sea levels, results are largely statistically insignificant. This is because in many regions large tidal variability dominates over the other components. Combining sea levels with an inundation and impact model shows that ENSO has a significant but small effect on the number of people potentially exposed to flooding at the globally aggregated scale. Our results demonstrate that a model‐based approach allows for an assessment of the influence of ENSO on coastal flood impacts and could be used to assess impacts of future changes in ENSO.
Storm Time Total Electron Content Modeling Over African Low‐Latitude and Midlatitude Regions
Authors: Uwamahoro Jean Claude , Habarulema John Bosco , Okouma Patrice Martin 
Published: September 2018

AbstractThis paper presents storm time total electron content (TEC) modeling results based on artificial neural networks, for both low‐latitude and midlatitude African regions. The developed storm time TEC models were based on Global Positioning System (GPS) observations from GPS receiver stations selected in low latitude, Northern and Southern hemisphere midlatitude regions of the African sector. GPS data selection was based on a storm criterion of
−50 nT and storm data sets used to develop the models were within the periods 2001–2015, 2000–2015, and 1998–2015, for African low latitude, Northern and Southern Hemisphere midlatitude regions, respectively. For the first time in storm time TEC modeling, the meridional wind velocity was introduced as an additional input to the well‐known TEC modeling inputs (diurnal variation, seasonal variation, solar activity, and geomagnetic activity representations) to take into account the effect of neutral winds in moving ionization within the ionosphere along the magnetic field lines. Results showed that the use of meridional wind as an additional input leads to overall percentage improvements of about 5%, 10%, and 5% for the low‐latitude, Northern and Southern Hemisphere midlatitude regions, respectively. High‐latitude storm‐induced winds and the interhemispheric blows of the meridional winds from summer to winter hemisphere may be associated with these improvements.
The Effects of Uncertainty in Initial CME Input Parameters on Deflection, Rotation, Bz, and Arrival Time Predictions
Authors: Kay C. , Gopalswamy N. 
Published: September 2018

AbstractUnderstanding the effects of coronal mass ejections (CMEs) requires knowing if and when they will impact and their properties upon impact. Of particular importance is the strength of a CME's southward magnetic field component (Bz). Kay et al. (2013, https://doi:10.1088/0004-637X/775/1/5, 2015, https://doi:10.1088/948 0004-637X/805/2/168) have shown that the simplified analytic model Forecasting a CME's Altered Trajectory (ForeCAT) can reproduce the deflection and rotation of CMEs. Kay, Gopalswamy, Reinard, and Opher (2017, https://doi.org/10.3847/1538-4357/835/2/117) introduced ForeCAT In situ Data Observer, which uses ForeCAT results to simulate magnetic field profiles. ForeCAT In situ Data Observer reproduces the in situ observations on roughly hourly time scales, suggesting that these models could be extremely useful for predictions of Bz. However, as with all models, both models are sensitive to their input parameters, which may not be precisely known for predictions. We explore this sensitivity using ensembles having small changes in the initial latitude, longitude, and orientation of the erupting CME. We explore the effects of different background magnetic field models and find that the changes in deflection and rotation resulting from the uncertainty in the initial parameters tend to exceed the changes from different magnetic backgrounds. The range in the in situ profiles tends to scale with the range in the deflection and rotation. We also consider a simple arrival time model using ForeCAT results and find an average absolute error of only 3 hr. We show that an uncertainty in the CME position of 8.1° ± 6.9° leads to variations of 6 hr in the arrival time. This measure depends strongly on the location of impact within the CME with the arrival time changing less for impacts near the nose.
Enhanced Escape of Spacecraft Photoelectrons Caused by Langmuir and Upper Hybrid Waves
Authors: Graham D. B. , Vaivads A. , Khotyaintsev Yu. V. , Eriksson A. I. , André M. , Malaspina D. M. , Lindqvist P.‐A. , Gershman D. J. , Plaschke F. 
Published: September 2018

AbstractThe spacecraft potential is often used to infer rapid changes in the thermal plasma density. The variations in spacecraft potential associated with large‐amplitude Langmuir and upper hybrid waves are investigated with the Magnetospheric Multiscale (MMS) mission. When large‐amplitude Langmuir and upper hybrid waves are observed, the spacecraft potential increases. The changes in spacecraft potential are shown to be due to enhanced photoelectron escape from the spacecraft when the wave electric fields reach large amplitude. The fluctuations in spacecraft potential follow the envelope function of the Langmuir and upper hybrid waves. Comparison with the high‐resolution electron moments shows that the changes in spacecraft potential associated with the waves are not due to density perturbations. Indeed, using the spacecraft potential as a density probe leads to unphysically large density fluctuations. In addition, the changes in spacecraft potential are shown to increase as density decreases: larger spacecraft potential changes are observed in the magnetosphere, than in the magnetosheath and solar wind. These results show that external electric fields can lead to unphysical results when the spacecraft potential is used as a density probe. The results suggest that fluctuations in the spacecraft potential alone cannot be used to determine whether nonlinear processes associated with Langmuir and upper hybrid waves, such as the ponderomotive force and three‐wave decay, are occurring.
Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation
Authors: Johnson Timothy I. , Costa Ana S. H. , Ferguson Ashley N. , Frezza Christian 
Published: September 2018

AbstractAn altered response to DNA damage is commonly associated with genomic instability, a hallmark of cancer. Fumarate hydratase (FH) was recently characterised as a DNA repair factor required in non-homologous end-joining (NHEJ) through the local production of fumarate. Inactivating germline mutations in FH cause hereditary leiomyomatosis and renal cell cancer (HLRCC), a cancer syndrome characterised by accumulation of fumarate. Recent data indicate that, in FH-deficient cells, fumarate suppresses homologous recombination DNA repair upon DNA double-strand breaks, compromising genome integrity. Here, we show that FH loss confers resistance to DNA damage caused by ionising radiation (IR), and promotes early mitotic entry after IR in a fumarate-specific manner, even in the presence of unrepaired damage, by suppressing checkpoint maintenance. We also showed that higher levels of DNA damage foci are detectable in untreated FH-deficient cells. Overall, these data indicate that FH loss and fumarate accumulation lead to a weakened G2 checkpoint that predisposes to endogenous DNA damage and confers resistance to IR.