bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clostridium difficile infection increases acute and chronic morbidity and mortality
Authors: Olsen Margaret A. , Stwalley Dustin , Demont Clarisse , Dubberke Erik R. 
Published: November 2018

AbstractObjectiveIn this study, we aimed to quantify short- and long-term outcomes of Clostridium difficile infection (CDI) in the elderly, including all-cause mortality, transfer to a facility, and hospitalizations.DesignRetrospective study using 2011 Medicare claims data, including all elderly persons coded for CDI and a sample of uninfected persons. Analysis of propensity score-matched pairs and the entire population stratified by the propensity score was used to determine the risk of all-cause mortality, new transfer to a long-term care facility (LTCF), and short-term skilled nursing facility (SNF), and subsequent hospitalizations within 30, 90, and 365 days.ResultsThe claims records of 174,903 patients coded for CDI were compared with those of 1,318,538 control patients. CDI was associated with increased risk of death (odds ratio [OR], 1.77; 95% confidence interval [CI], 1.74–1.81; attributable mortality, 10.9%), new LTCF transfer (OR, 1.74; 95% CI, 1.67–1.82), and new SNF transfer (OR, 2.52; 95% CI, 2.46–2.58) within 30 days in matched-pairs analyses. In a stratified analysis, CDI was associated with greatest risk of 30-day all-cause mortality in persons with lowest baseline probability of CDI (hazard ratio [HR], 3.04; 95% CI, 2.83–3.26); the risk progressively decreased as the baseline probability of CDI increased. CDI was also associated with increased risk of subsequent 30-day, 90-day, and 1-year hospitalization.ConclusionsCDI was associated with increased risk of short- and long-term adverse outcomes, including transfer to short- and long-term care facilities, hospitalization, and all-cause mortality. The magnitude of mortality risk varied depending on baseline probability of CDI, suggesting that even lower-risk patients may benefit from interventions to prevent CDI.
Geomorphic and tectonic implications of the endorheic to exorheic transition of the Ebro River system in northeast Iberia
Authors: Soria-Jáuregui Ángel , Jiménez-Cantizano Francisco , Antón Loreto 
Published: November 2018

AbstractThe Ebro catchment includes a continental foreland basin that underwent an endorheic–exorheic transition. Morphometric studies, including hypsometric curves, hypsometric integrals, asymmetry factor, mountain front sinuosity, normalised stream-length gradient, and normalised concavity indices for the Ebro River and 32 of its tributaries, show the signals of transient response to this major drainage change. The Ebro River, its upper catchment tributaries, and the Pyrenean tributaries have concave-up longitudinal profiles, concave hypsometric curves, and low hypsometric integrals, parameters typical of deeply dissected basins. This suggests a mature stage of development, controlled by the shift of the base level to the Mediterranean Sea. Iberian Range tributaries display low concavity profiles with numerous knickpoints and high values of hypsometric integral, indicating a transient state as a response to tectonic uplift, ratified by the values of mountain front sinuosity surrounding the basin.
Absolute Time Ranges in the Plateau of the Late Bronze to Iron Age Transition and the Appearance of Bichrome Pottery in Canaan, Southern Levant
Authors: Asscher Yotam , Boaretto Elisabetta 
Published: November 2018

ABSTRACTThe Late Bronze Age to Iron Age transition in the Levant includes the appearance of new material culture that is similar in styles to the Aegean world. In the southern Levant, the distribution of early styles of Aegean-like pottery, locally produced, is limited to the coastal areas of Canaan, making synchronization with the rest of the region difficult. Radiocarbon (14C) dating provides a high-resolution absolute chronological framework for synchronizing ceramic phases. Here, absolute14C chronologies of the Late Bronze to Iron Age transition in the sites Tel Beth Shean, Tel Rehov, Tel Lachish, and Tel Miqne-Ekron are determined. Results show that the ranges of transitions vary in an absolute time frame by 50–100 years between different sites and that the range of the Late Bronze Age to Iron Age transition in Canaan spans the 13th–11th centuries BC plateau. These chronologies, based on a site-by-site approach for dating, show that the change between early types of Aegean-like pottery (Monochrome) to developed types (Bichrome), occurred over 100 years in Canaan and that the transition occurred in southern sites prior to sites in the north. These ranges show that not only is the Late Bronze to Iron Age not contemporaneous, but also synchronization between sites based on their ceramic assemblages is problematic.
Racial Attitudes and Health Care Policy Opinion: An Anglx–Latinx Contrast
Authors: Lanford Daniel , Block Ray , Tope Daniel 
Published: November 2018

AbstractRecent studies confirm that Anglxs’ racial attitudes can shape their opinions about the Affordable Care Act (ACA), particularly when this federal health care policy is linked to Barack Obama. Strong linkages made between Obama and the ACA cue Anglxs to apply their racialized feelings toward Obama to their health policy preferences. This is consistent with a growing body of research demonstrating that “racial priming” can have a powerful impact on Anglxs’ political opinions. Yet few studies have explored racialized policy opinion among minorities, and fewer still have explored racial priming among Latinxs. In this paper, we compare the effect of racial priming on the health policy preferences of Latinxs and Anglxs. Using survey evidence from the 2012 American National Election Study, we find important Anglx–Latinx differences in racialized policy preferences. However, we also find that racial priming has an effect on U.S.-born Latinxs that closely resembles its effect on Anglxs. Results suggest that increasing ethnic diversity in the United States will not necessarily produce increasingly liberal politics as many believe. American politics in the coming decades will depend largely on the ways in which Latinxs’ racial sympathies and resentments are mobilized.
Parasite-specific proliferative responses of chicken spleen cells upon in vitro stimulation with Eimeria tenella antigen
Authors: Wattrang Eva , Thebo Per , Ibrahim Osama , Dalgaard Tina Sørensen , Lundén Anna 
Published: November 2018

AbstractThis study aimed to set up methodology to monitor parasite-specific T-cell activation in vitro using Eimeria tenella-infected chickens. A sonicated E. tenella sporozoite protein preparation was used for the activation of chicken spleen cell cultures. Proliferation assessed by 3H-thymidin incorporation or blast transformation of T-cells assessed by immunofluorescence labelling and flow cytometry were used as read-outs for activation. Results showed that E. tenella-specific proliferation was detected in cultures of spleen cells collected in a ‘window’ between 8 and 14 days after primary infection. However, due to high variation in proliferative responses between individuals and to high background proliferation, large numbers of observations were needed to obtain significant results. Moreover, the outcome was not improved by increasing the infection dose to chickens or by depletion of T-cell receptor (TCR) γ/δ expressing cells from cultures. An E. tenella-specific blast transformation response was observed for TCRα/β expressing cells within the same ‘window’, confirming the identity of the responding cells as classic T-cells. Thus, it is possible to study the kinetics of E. tenella-specific T-cell responses in vitro. However, more in-depth phenotypic identification of the responding T-cells could improve the methodology.
Neural circuitry and precision medicines for mental disorders: are they compatible?
Authors: Dean Charles E. 
Published: November 2018

AbstractGiven the failure of psychiatry to develop clinically useful biomarkers for psychiatric disorders, and the concomitant failure to develop significant advances in diagnosis and treatment, the National Institute of Mental Health (NIMH) in 2010 launched the Research Domain Criteria (RDoC), a framework for research based on the assumption that mental disorders are disorders of identifiable brain neural circuits, with neural circuitry at the center of units of analysis ranging from genes, molecules, and cells to behavior, self-reports, and paradigms. These were to be integrated with five validated dimensional psychological constructs such as negative and positive valence systems. Four years later, the NIMH stated that the ultimate goal of RDoC is precision medicine for psychiatry, with the assumption that precision medications will normalize dysfunctional neural circuits. How this could be accomplished is not obvious, given that neural circuits are widely distributed, have unclear boundaries, and exhibit a significant degree of neuroplasticity, with multiple circuits present in any given disorder. Moreover, the early focus on neural circuitry has been criticized for its reductionism and neglect of the more recent RDoC emphasis on the integration and equivalence of biological and psychological phenomena. Yet this seems inconsistent with the priorities of the NIMH director, an advocate of the central role of neural circuitry and projects such as the Brain Initiative and the Human Connectome Project. Will such projects, at a cost of at least $10 billion, lead to precision medications for mental disorders, or further diminish funding for clinical care and research?
Trends in incidence and mortality of tuberculosis in Japan: a population-based study, 1997–2016
Authors: Hagiya H. , Koyama T. , Zamami Y. , Minato Y. , Tatebe Y. , Mikami N. , Teratani Y. , Ohshima A. , Shinomiya K. , Kitamura Y. , Sendo T. , Hinotsu S. , Tomono K. , Kano M. R. 
Published: November 2018

AbstractJapan is still a medium-burden tuberculosis (TB) country. We aimed to examine trends in newly notified active TB incidence and TB-related mortality in the last two decades in Japan. This is a population-based study using Japanese Vital Statistics and Japan Tuberculosis Surveillance from 1997 to 2016. We determined active TB incidence and mortality rates (per 100 000 population) by sex, age and disease categories. Joinpoint regression was applied to calculate the annual percentage change (APC) in age-adjusted mortality rates and to identify the years showing significant trend changes. Crude and age-adjusted incidence rates reduced from 33.9 to 13.9 and 37.3 to 11.3 per 100 000 population, respectively. Also, crude and age-adjusted mortality rates reduced from 2.2 to 1.5 and 2.8 to 1.0 per 100 000 population, respectively. Average APC in the incidence and mortality rates showed significant decline both in men (−6.2% and −5.4%, respectively) and women (−5.7% and −4.6%, respectively). Age-specific analysis demonstrated decreases in incidence and mortality rates for every age category, except for the incidence trend in the younger population. Although trends in active TB incidence and mortality rates in Japan have favourably decreased, the rate of decline is far from achieving TB elimination by 2035.
Effects of Integrated Polyethylene and Cover Crop Mulch, Conservation Tillage, and Herbicide Application on Weed Control, Yield, and Economic Returns in Watermelon
Authors: Price Andrew J. , Williams Jacob P. , Duzy Leah A. , McElroy J. Scott , Guertal Elizabeth A. , Li Steve 
Published: November 2018

AbstractA 3-yr watermelon experiment was established in fall 2013 to evaluate cover crop, polyethylene mulch, tillage, and herbicide application components for weed control, yield, and profitability. Conservation tillage, either with a cereal rye cover crop alone or integrated with polyethylene mulch, was compared to the standard industry practice of conventional tillage with bedded polyethylene mulch. The study also used a non-bedded conventional tillage system without polyethylene to determine polyethylene and cover crop residue effects. Within each of the four systems, herbicide treatments comprised halosulfuron applied (1) at 26.3 g ai ha–1PRE, (2) at 26.3 g ai ha–1POST, or (3) sequentially at 26.3 g ai ha–1PRE and POST. Each system also had a nontreated control. In addition, clethodim was applied in all plots twice POST at 140 g ai ha–1, except for nontreated in each system. In 2014, polyethylene or cereal rye cover crop effectively controlled tall morningglory, coffee senna, and carpetweed early season in nontreated plots, whereas the integration of the two was effective at controlling common purslane. Tall morningglory and purslane control was insufficient late season regardless of production system and herbicide application. In 2015, polyethylene effectively controlled cutleaf eveningprimrose, sicklepod, and arrowleaf sida early season in nontreated plots. Yellow nutsedge control was insufficient late season regardless of production system and herbicide application. Utilizing sequential halosulfuron applications did not increase weed control over PRE or POST alone in all years. Polyethylene use resulted in yields higher than systems without in all years. Across all 3 yr, net returns were highest for polyethylene mulch systems. The results of this experiment underscore the need for more progress in developing integrated conservation systems for watermelon production. Effective herbicides, low-disturbance cultivation, and/or hand weeding are most likely the key to success in conservation specialty crop systems.
Field Measurements of Drift of Conventional and Drift Control Formulations of 2,4-D Plus Glyphosate
Authors: Havens Patrick L. , Hillger David E. , Hewitt Andrew J. , Kruger Greg R. , Marchi-Werle Lia , Czaczyk Zbigniew 
Published: November 2018

AbstractRecent advances in biotechnology have resulted in crops that are tolerant to the synthetic auxin 2,4-D, expanding the weed management versatility of this herbicide. With potential expansions of use, concerns have been raised about the increased risk of herbicide drift, leading to damage to nontarget crops. A field-scale study was conducted with the objective to measure drift deposition and the potential for drift reduction conferred by a proprietary pre-mixture formulation of 2,4-D choline salt plus glyphosate dimethylammonium salt compared to an in-tank mixture of 2,4-D dimethylamine salt plus glyphosate potassium salt. Treatments were made with field-scale spray equipment under typical application conditions in McCook, NE, using three widely used nozzle tips. Deposition was captured in triplicate downwind collector lines and assayed for tracer dye and 2,4-D. In comparison to the in-tank mixture, the pre-mixture formulation exhibited lower downwind depositions when applied through a flat-fan (TeeJet Extended Range; XR) and air induction (TeeJet Air Induction Extended Range; AIXR) nozzles, but not with a pre-orifice (TeeJet TurboTeeJet Induction; TTI) nozzle. Based upon median deposition at 30 m downwind, the pre-mixture formulation reduced drift by 62% and 91%, for the XR and AIXR nozzles, respectively. From a drift reduction perspective, the pre-mixture formulation performance with the AIXR nozzle was equivalent to a much coarser TTI nozzle while still offering sufficient foliar coverage for acceptable weed control.
Alternative Vine Management Programs for Fresh-Market Potatoes
Authors: Lemke Matthew J. , Colquhoun Jed B. , Heider Daniel J. , Rittmeyer Richard A. 
Published: November 2018

AbstractEconomically solvent fresh-market potato production is predominantly dependent on the ability to efficiently produce consistent tuber quality and high yield, and the ability to meet first-to-market demand with early-season potatoes. Unfortunately, these two qualifiers often work against each other in terms of production management. In response, we studied integrated potato vine management programs that support timely early-season potato harvest. Vine management with a flail chopper, roller, and flame burner used alone or followed by diquat was evaluated when initiated 21 or 14 d prior to harvest in 2015 and 2016. Potato varieties included ‘Yukon Gold’ and ‘Dark Red Norland’. Potato leaf and stem management, as well as tuber skinning, stolon separation, grade, and yield were quantified. Among mechanical methods, potato leaf and stem management were poor when vines were rolled or mowed but better when flail chopped. In general, vine management and tuber skin set was better when treatments were initiated 21 d prior to harvest as opposed to 14 d. Vine management, tuber skin set, and yield were comparable when potato vines were flail chopped followed by flame burning and where diquat was applied twice, offering a viable program for smaller scale or organic production.
Critical Period for Palmer Amaranth (Amaranthus palmeri) Control in Pickling Cucumber
Authors: McGowen Samuel J. , Jennings Katherine M. , Chaudhari Sushila , Monks David W. , Schultheis Jonathan R. , Reberg-Horton Chris 
Published: November 2018

AbstractField studies were conducted in North Carolina to determine the critical period for Palmer amaranth control (CPPAC) in pickling cucumber. In removal treatments (REM), emerged Palmer amaranth were allowed to compete with cucumber for 14, 21, 28, or 35 d after sowing (DAS) in 2014 and 14, 21, 35, or 42 DAS in 2015, and cucumber was kept weed-free for the remainder of the season. In the establishment treatments (EST), cucumber was maintained free of Palmer amaranth by hand removal until 14, 21, 28, or 35 DAS in 2014 and until 14, 21, 35, or 42 DAS in 2015; after this, Palmer amaranth was allowed to establish and compete with the cucumber for the remainder of the season. The beginning and end of the CPPAC, based on 5% loss of marketable yield, was determined by fitting log-logistic and Gompertz equations to the relative yield data representing REM and EST, respectively. Season-long competition by Palmer amaranth reduced pickling cucumber yield by 45% to 98% and 88% to 98% during 2014 and 2015, respectively. When cucumber was planted on April 25, 2015, the CPPAC ranged from 570 to 1,002 heat units (HU), which corresponded to 32 to 49 DAS. However, when cucumber planting was delayed 2 to 4 wk (May 7 and May 21, 2014 and May 4, 2015), the CPPAC lasted from 100 to 918 HU (7 to 44 DAS). This research suggested that planting pickling cucumber as early as possible during the season may help to reduce competition by Palmer amaranth and delay the beginning of the CPPAC.
Insecticide Seed Treatments Partially Safen Rice to Low Rates of Glyphosate and Imazethapyr
Authors: Martin Steven M. , Norsworthy Jason K. , Scott Robert C. , Hardke Jarrod , Lorenz Gus M. , Gbur Ed 
Published: November 2018

AbstractEach year there are multiple reports of drift occurrences, and the majority of drift complaints in rice are from imazethapyr or glyphosate. In 2014 and 2015, multiple field experiments were conducted near Stuttgart, AR, and near Lonoke, AR, to evaluate whether insecticide seed treatments would reduce injury from glyphosate or imazethapyr drift or decrease the recovery time following exposure to a low rate of these herbicides. Study I was referred to as the “seed treatment study,” and Study II was the “drift timing study.” In the seed treatment study the conventional rice cultivar ‘Roy J’ was planted, and herbicide treatments included imazethapyr at 10.5 g ai ha–1, glyphosate at 126 g ae ha–1, or no herbicide. Each plot had either a seed treatment of thiamethoxam, clothianidin, chlorantraniliprole, or no insecticide seed treatment. The herbicides were applied at the two- to three-leaf growth stage. Crop injury was assessed 1, 3, and 5 wk after application. Averaged over site-years, thiamethoxam-treated rice had less injury than rice with no insecticide seed treatment at each rating, along with an increased yield. Clothianidin-treated rice had an increased yield over no insecticide seed treatment, but the reduction in injury for both herbicides was less pronounced than in the thiamethoxam-treated plots. Overall, chlorantraniliprole was generally the least effective of the three insecticides in reducing injury from either herbicide and in protecting rice yield potential. A second experiment conducted at Stuttgart, AR, was meant to determine whether damage to rice from glyphosate and imazethapyr was influenced by the timing (15, 30, and 45 d after planting) of exposure to herbicides for thiamethoxam-treated and nontreated rice. There was an overall reduction in injury with the use of thiamethoxam, but the reduction in injury was not dependent on the timing of the drift event. Reduction in damage from physical drift of glyphosate and imazethapyr as well as increased yields over the absence of an insecticide seed treatment appear to be an added benefit.
Hydrologic Controls of Methane Dynamics in Karst Subterranean Estuaries
Authors: Brankovits D. , Pohlman J. W. , Ganju N. K. , Iliffe T. M. , Lowell N. , Roth E. , Sylva S. P. , Emmert J. A. , Lapham L. L. 
Published: November 2018

AbstractKarst subterranean estuaries (KSEs) extend into carbonate platforms along 12% of all coastlines. A recent study has shown that microbial methane (CH4) consumption is an important component of the carbon cycle and food web dynamics within flooded caves that permeate KSEs. In this study, we obtained high‐resolution (~2.5‐day) temporal records of dissolved methane concentrations and its stable isotopic content (δ13C) to evaluate how regional meteorology and hydrology control methane dynamics in KSEs. Our records show that less methane was present in the anoxic fresh water during the wet season (4,361 ± 89 nM) than during the dry season (5,949 ± 132 nM), suggesting that the wet season hydrologic regime enhances mixing of methane and other constituents into the underlying brackish water. The δ13C of the methane (−38.1 ± 1.7‰) in the brackish water was consistently more 13C‐enriched than fresh water methane (−65.4 ± 0.4‰), implying persistent methane oxidation in the cave. Using a hydrologically based mass balance model, we calculate that methane consumption in the KSE was 21–28 mg CH4·m−2·year−1 during the 6‐month dry period, which equates to ~1.4 t of methane consumed within the 102‐ to 138‐km2 catchment basin for the cave. Unless wet season methane consumption is much greater, the magnitude of methane oxidized within KSEs is not likely to affect the global methane budget. However, our estimates constrain the contribution of a critical resource for this widely distributed subterranean ecosystem.
Use of Satellite Soil Moisture to Diagnose Climate Model Representations of European Soil Moisture‐Air Temperature Coupling Strength
Authors: Dong Jianzhi , Crow Wade T. 
Published: November 2018

AbstractSoil moisture‐air temperature coupling (SMTC) strength affects European summer air temperature variability. However, due to a lack of spatially extensive ground‐based soil moisture observations, General Circulation Model predictions of European‐mean SMTC strength have not been adequately verified and contain substantial uncertainties. Here we utilize remotely sensed soil moisture to evaluate estimates of SMTC strength provided by seven Coupled Model Intercomparison Project Phase 5 (CMIP5) General Circulation Models (GCMs). Soil moisture retrievals provided by the Soil Moisture Active/Passive (SMAP) mission are shown to be uniquely suited for this purpose. Comparisons to SMAP‐based estimates suggest that CMIP5 GCMs generally underestimate SMTC strengths—particularly in central Europe. This result is consistent with previous modeling work and highlights the value of L‐band soil moisture remote sensing for land surface‐atmosphere coupling analyses.