bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring hospital spatial wingspan by using a discrete choice model with utility-threshold
Authors: Issa Saley , Mathieu Ribatet , Nicolas Molinari 
Published: November 2018

AbstractPolicy makers increasingly rely on hospital competition to incentivize patients to choose high-value care. Travel distance is one of the most important drivers of patients’ decision. The paper presents a method to numerically measure, for a given hospital, the distance beyond which no patient is expected to choose the hospital for treatment by using a new approach in discrete choice models. To illustrate, we compared 3 hospitals attractiveness related to this distance for asthma patients admissions in 2009 in Hérault (France), showing, as expected, CHU Montpellier is the one with the most important spatial wingspan. For estimation, Monte Carlo Markov Chain (MCMC) methods are used.
TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys
Authors: Kurimoto Emi , Nakashima Masato , Kimura Haruhide , Suzuki Motohisa 
Published: November 2018

AbstractActivation of the muscarinic M1 receptor is a promising approach to improve cognitive deficits associated with cholinergic dysfunction in Alzheimer’s disease, dementia with Lewy bodies, and schizophrenia. TAK-071 is an M1-selective positive allosteric modulator that improves cognitive deficits induced by scopolamine, a non-selective muscarinic receptor antagonist, with reduced side effects on gastrointestinal function in rats. In this study, we explored changes in quantitative electroencephalography (qEEG) power bands, with or without scopolamine challenge, as a non-invasive translational biomarker for the effect of TAK-071 in cynomolgus monkeys. Scopolamine has been reported to increase theta and delta power bands and decrease alpha power band in healthy volunteers. In line with the clinical observations, scopolamine (25–100 µg/kg, subcutaneous administration [s.c.]) increased theta and delta power bands in cynomolgus monkeys in a dose-dependent manner, whereas it had the opposite effect on alpha power band. The effects of TAK-071 on scopolamine (25 µg/kg, s.c.)-induced qEEG spectral changes were examined using an acetylcholinesterase inhibitor donepezil and a muscarinic M1/M4 receptor agonist xanomeline as comparative cholinomimetics. TAK-071 (0.3–3 mg/kg, oral administration [p.o.]), donepezil (3 mg/kg, p.o.), and xanomeline (1 mg/kg, s.c.) suppressed the scopolamine-induced increases in alpha, theta, and delta power bands. These results suggest that changes in specific qEEG power bands, in particular theta and delta power bands in the context of scopolamine challenge, could be used as translational biomarkers for the evaluation of TAK-071 in clinical studies.
Triple layered QSAR Studies on Substituted 1,2,4-Trioxanes as potential antimalarial agents: Superiority of the Quantitative Pharmacophore-Based Alignment, Over Common Substructure based Alignment
Authors: Gupta Amit K. , Saxena Anil K. 
Published: November 2018

AbstractThe present study reports the utilization of three approaches viz Pharmacophore, CoMFA, CoMSIA and HQSAR studies to identify the essential structural requirements in 3D chemical space for the modulation of the antimalarial activity of substituted 1,2,4 trioxanes. The superiority of Quantitative pharmacophore based alignment (QuantitativePBA) over global minima energy conformer-based alignment (GMCBA) has been reported in CoMFA and CoMSIA studies. The developed models showed good statistical significance in internal validation (q2, group cross-validation and bootstrapping) and performed very well in predicting antimalarial activity of test set compounds. Structural features in terms of their steric, electrostatic, and hydrophobic interactions in 3D space have been found important for the antimalarial activity of substituted 1,2,4-trioxanes. Further, the HQSAR studies based on the same training and test set acted as an additional tool to find the sub-structural fingerprints of substituted 1,2,4 trioxanes for their antimalarial activity. Together, these studies may facilitate the design and discovery of new substituted 1,2,4-trioxane with potent antimalarial activity.
A bump in the road: speed bumps’ impact on property values
Authors: Graham John Edward , Jones Adam Talbot 
Published: November 2018

PurposeSpeed bumps invite varied responses from homeowners, drivers and policymakers. Parents of small children like speed bumps, if they slow the passing traffic, but prospective home buyers may reject a home with a speed bump nearby, contemplating the traversal of it thousand times during an ownership period. The purpose of this study is to empirically identify the effect of speed bumps on home values.Design/methodology/approachAnalysis presented here is based on an examination of home sales prices and exploits variation in the number of speed bumps traversed and the installation of speed bumps to identify the effect of speed bumps on home values. An anonymous online survey is also used to shed light on drivers of the empirical results.FindingsInitial results exploiting variation in the number of bumps traversed suggest speed bumps are associated with reduced residential property values. An estimated treatment effect of speed bump installation underscores the original findings. Finally, survey results imply that older homeowners and homeowners with children may favor speed bumps but less than the disfavor of those who do not.Research limitations/implicationsThe research presented here applies to speed bumps in residential areas and on streets not considered through streets.Practical implicationsThe findings suggest that planners should investigate options such as medians and roundabouts instead of speed bumps.Social implicationsThese results suggest that communities can be visually improved and home values lifted through the removal of speed bumps and installation of other traffic control devices.Originality/valueThis research is valuable to residential developers, planners and neighborhood associations across the country.
Seeing through touch: a conceptual framework of visual-tactile interplay
Authors: Eklund Andreas Aldogan , Helmefalk Miralem 
Published: November 2018

Purpose
The purpose of this paper is to develop a comprehensive conceptual framework of visual-tactile interplay and consumer responses in brand, product and servicescape contexts.

Design/methodology/approach
This paper performs a literature review of visual-tactile interplay by reviewing prior research in marketing and psychology.

Findings
The review reveals that visual-tactile interplay provokes various consumer responses depending on whether brands, products or servicescapes are used. The paper develops a comprehensive conceptual framework mapping out visual-tactile interplay and the relationship with consumers’ cognition, emotions and behaviors.

Research limitations/implications
A conceptual model was developed with a novel view on how visual and tactile cues can together influence consumer responses.

Practical implications
This paper shows how visual-tactile interplay is successful in brand, product and servicescape contexts and provides practical insight for firms into how to provoke consumers’ cognitive, emotional and behavioral responses.

Originality/value
This paper contributes to existing literature by developing a conceptual framework and model of visual-tactile interplay and consumer responses by drawing on research in marketing and psychology.
Risk aversion decomposition and the impact of monetary policy surprises on aggregate tail risk aversion
Authors: Chen Denghui 
Published: November 2018

Purpose
The purpose of this paper is to present theoretical and empirical support that the fear component associated with rare events has an impact on risk premium and market returns.

Design/methodology/approach
Extension of jump-diffusion model to extract the fear component from representative agent risk aversion, Standard VAR and impulse response function analysis, Event study analysis.

Findings
The model implicates that investor fear of tail jumps in the financial market impacts equity risk premium. The empirical findings show both positive stock and monetary policy shocks decrease investor’s fear. It can be attributed to that a bullish stock market and an increase in interest rate reflects expanding economy, and it leads to a decrease in fear. Moreover, a surprise decline in the expected short-term rate has a mixed impact on tail risk aversion. A plausible explanation is that investors believe a surprise drop in an expected short-term rate reflects a fast deteriorating economic outlook during unconventional monetary policy period.

Originality/value
This paper provides theoretical framework to decompose risk aversion into two separate components: one component associated with daily volatility, and the fear component associated with rare events. The study uses risk premiums decomposed from Chicago Board Options Exchange volatility index as proxies for the two components of risk aversion, and then utilizes standard value at risk and event study analysis to show the fear component plays a role in risk premium and market return.
Context-aware restricted Boltzmann machine meets collaborative filtering
Authors: Zhang Jingshuai , Ouyang Yuanxin , Xie Weizhu , Rong Wenge , Xiong Zhang 
Published: November 2018

Purpose
The purpose of this paper is to propose an approach to incorporate contextual information into collaborative filtering (CF) based on the restricted Boltzmann machine (RBM) and deep belief networks (DBNs). Traditionally, neither the RBM nor its derivative model has been applied to modeling contextual information. In this work, the authors analyze the RBM and explore how to utilize a user’s occupation information to enhance recommendation accuracy.

Design/methodology/approach
The proposed approach is based on the RBM. The authors employ user occupation information as a context to design a context-aware RBM and stack the context-aware RBM to construct DBNs for recommendations.

Findings
The experiments on the MovieLens data sets show that the user occupation-aware RBM outperforms other CF models, and combinations of different context-aware models by mutual information can obtain better accuracy. Moreover, the context-aware DBNs model is superior to baseline methods, indicating that deep networks have more qualifications for extracting preference features.

Originality/value
To improve recommendation accuracy through modeling contextual information, the authors propose context-aware CF approaches based on the RBM. Additionally, the authors attempt to introduce hybrid weights based on information entropy to combine context-aware models. Furthermore, the authors stack the RBM to construct a context-aware multilayer network model. The results of the experiments not only convey that the context-aware RBM has potential in terms of contextual information but also demonstrate that the combination method, the hybrid recommendation and the multilayer neural network extension have significant benefits for the recommendation quality.
The USA as a victim of international/transnational terrorism targeting what it is or what it does?
Authors: Zahra Heba 
Published: November 2018

PurposeThe USA has been suffering from international/transnational terrorism for decades. There is no consensus on whether this situation is a result of the international status of the USA and the principles it upholds or the policies it embraces in its interaction with the outside world.Design/methodology/approachThis study adopts both the “American Primacy” theory and the “anti-Americanism” theory in its effort to reach a conclusion concerning this issue. This study aims to examine previous research that linked international terrorism to the US hegemony and the principles it abides by and showed the relevance of this perception to the “American Primacy” theory. It also examines the research that considered international/transnational terrorism as a result of the American foreign policy in its various aspects (economic, military, assistance or a whole combination of policies).FindingsThis literature on the American foreign policy and international/transnational terrorism was extensive and manifested the explanatory power of the “anti-Americanism” theory, especially in its three variants: issue-oriented, ideological and instrumental. While examining the foreign policy terrorism studies, the relevance of the “American Primacy” theory appeared at very few instances.Originality/valueThe study was able to prove that explaining the international/transnational terrorism is related to the foreign policy decisions taken by the American policymakers and cause harm to the outside world. The envy of “American Primacy” is of secondary importance.
Spillovers from entry: the impact of bank branch network expansion
Authors: Kuehn Joseph 
Published: November 2018

AbstractI study why local banking markets became dominated by multimarket firms following deregulation in the 1990s. I estimate a model of branch entry that allows for spillovers across markets. The spillovers complicate estimation, and so I develop a revealed preference approach that also deals with unobserved firm and market heterogeneity. I then analyze the impact of multimarket banks and find that they increase local competition, but that they also open more branches than single‐market firms, and subsequently offer lower deposit rates. Ultimately, their welfare impact differs across markets based on the availability of outside alternatives and consumer sensitivity to rates.
Massive release of the histamine‐degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients
Authors: Boehm Thomas , Reiter Birgit , Ristl Robin , Petroczi Karin , Sperr Wolfgang , Stimpfl Thomas , Valent Peter , Jilma Bernd 
Published: November 2018

AbstractBackgroundHistaminolytic activity mediated by diamine oxidase (DAO) is present in plasma after induction of severe anaphylaxis in rats, guinea pigs, and rabbits. Heparin released during mast cell degranulation in the gastrointestinal tract might liberate DAO from heparin‐sensitive storage sites. DAO release during anaphylaxis has not been demonstrated in humans.MethodsPlasma DAO, tryptase, and histamine concentrations of four severe anaphylaxis events were determined at multiple serial time points in two patients with systemic mastocytosis. The histamine degradation rates were measured in anaphylaxis samples and in pregnancy sera and plasma with comparable DAO concentrations.ResultsMean DAO (132 ng/mL) and tryptase (304 ng/mL) concentrations increased 187‐ and 4.0‐fold, respectively, over baseline values (DAO 0.7 ng/mL, tryptase 76 ng/mL) during severe anaphylaxis. Under non‐anaphylaxis conditions, DAO concentrations were not elevated in 29 mastocytosis patients compared to healthy volunteers and there was no correlation between DAO and tryptase levels in mastocytosis patients. The histamine degradation rate of DAO in plasma from mastocytosis patients during anaphylaxis is severely compromised compared to DAO from pregnancy samples.ConclusionDuring severe anaphylaxis in mastocytosis patients, DAO is likely released from heparin‐sensitive gastrointestinal storage sites. The measured concentrations can degrade histamine, but DAO activity is compromised compared to pregnancy samples. For accurate histamine measurements during anaphylaxis, DAO inhibition is essential to inhibit further histamine degradation after blood withdrawal. Determination of DAO antigen levels might be of clinical value to improve the diagnosis of mast cell activation.
Impact of knowledge, attitude and preceptor behaviour in pharmacovigilance education
Authors: Yu Yun Mi , Kim Seungyeon , Choi Kyung Hee , Jeong Kyeong Hye , Lee Euni 
Published: November 2018

AbstractThis study aimed to determine the level of pharmacovigilance (PV) education in pharmacy programmes and to evaluate the predictive factors for the intent to report adverse drug reactions (ADRs) by pharmacy students in South Korea. Self‐administered questionnaires were collected from a regionally stratified nationwide convenience sample of pharmacy students in September 2017. The association between students' intent to report ADRs and their knowledge and attitude was evaluated by using multivariate logistic regression analysis. In total, 303 pharmacy students participated in the survey; the average age of students was 26.7 (standard deviation 2.9) years and 40.6% were males. Eighty‐eight students (29%) marked the degree of their intent as “strongly high.” Increased knowledge of ADR reporting methods and positive attitude towards the need for ADR reporting were significant predictors of the intent to report ADRs. Further, witnessing reporting by the preceptor (adjusted odds ratio, 2.37; 95% confidence interval, 1.26‐4.46; P < 0.01) was significantly correlated with the knowledge on and attitude towards ADR reporting of pharmacy students. The findings of our study indicated the need for improvements in PV curriculum, such as educational content focused on ADR reporting methods and demonstration of a preceptor's reporting in pharmacy practice experiential rotation, within Korean college of pharmacy curriculum.
Impact of abusive supervision on deviant work behavior: The role of Islamic work ethic
Authors: Javed Basharat , Fatima Tasneem , Yasin Raja Mehtab , Jahanzeb Sadia , Rawwas Muhammad Y. A. 
Published: November 2018

AbstractIn this article, we examined the relationship between abusive supervision and deviant workplace behavior and the moderating role of an Islamic Work Ethic. Three hundred and thirty‐six employees in different organizations (specializing in software development, medicine, law enforcement, telecommunication, pharmaceutics, and banking) across Pakistan completed our questionnaire. The results revealed that abusive supervision was positively related to deviant workplace behavior. Moreover, the moderation of an Islamic Work Ethic on the relationship between abusive supervision and deviant work behavior was confirmed. The study contributed in many ways. It expanded literature by revealing a weaker relationship between abusive supervision and deviant behavior when Islamic Work Ethic (IWE) was high. It also tested the conservation of resources theory by providing a plausible reasoning of the role of IWE in employee motivation. By integrating IWE as a resource in the workplace, practitioners would learn that the proper use of resources would produce satisfied workers who would not indulge in deviant workplace behaviors.
Single fraction carbon ion radiotherapy for colorectal cancer liver metastasis: A dose escalation study
Authors: Makishima Hirokazu , Yasuda Shigeo , Isozaki Yuka , Kasuya Goro , Okada Naomi , Miyazaki Masaru , Mohamad Osama , Matsufuji Naruhiro , Yamada Shigeru , Tsuji Hiroshi , Kamada Tadashi ,   the Liver Cancer Working Group
Published: November 2018

Prognosis is usually grim for those with liver metastasis from colorectal cancer (CRC) who cannot receive resection. Radiation therapy can be an option for those unsuitable for resection, with carbon ion radiotherapy (CIRT) being more effective and less toxic than X‐ray due to its physio‐biological characteristics. The objective of this study is to identify the optimal dose of single fraction CIRT for colorectal cancer liver metastasis. Thirty‐one patients with liver metastasis from CRC were enrolled in the present study. Twenty‐nine patients received a single‐fraction CIRT, escalating the dose from 36 Gy (RBE) in 5% to 10% increments until unacceptable incidence of dose‐limiting toxicity was observed. Dose‐limiting toxicity was defined as grade ≥3 acute toxicity attributed to radiotherapy. The prescribed doses were as follows: 36 Gy (RBE) (3 cases), 40 Gy (2 cases), 44 Gy (4 cases), 46 Gy (6 cases), 48 Gy (3 cases), 53 Gy (8 cases) and 58 Gy (3 cases). Dose‐limiting toxicity was not observed, but late grade 3 liver toxicity due to biliary obstruction was observed in 2 patients at 53 Gy (RBE). Both cases had lesions close to the hepatic portal region, and, therefore, the dose was escalated to 58 Gy (RBE), limited to peripheral lesions. The 3‐year actuarial overall survival rate of all 29 patients was 78%, and the median survival time was 65 months. Local control improved significantly at ≥53 Gy (RBE), with a 3‐year actuarial local control rate of 82%, compared to 28% in lower doses. Treatment for CRC liver metastasis with single‐fraction CIRT appeared to be safe up to 58 Gy (RBE) as long as the central hepatic portal region was avoided.
Social Networks of Children With Developmental Language Disorder in Inclusive Preschool Programs
Authors: Chen Jing , Justice Laura M. , Rhoad‐Drogalis Anna , Lin Tzu‐Jung , Sawyer Brook 
Published: November 2018

This study takes an ecological approach to examine how children with developmental language disorder (DLD) interact with their classmates within early childhood special education (ECSE) inclusive classrooms. Participants were 124 children with DLD, 56 children with other disabilities, and 247 typically developing children (Mage = 52.42 months, SD = 6.27) from 56 ECSE inclusive classrooms. Results of social network analysis showed that children with DLD had significantly smaller peer social networks and were more likely to be isolated. Children tended to interact with peers with the same DLD status. These effects of children's DLD status were above and beyond the effects of children's social pragmatics skills.
“Still We Need Friends!”: “Partnership in Mission” in the History of the World Council of Churches, 1948–2018
Authors: Han Kang‐Hee 
Published: November 2018

AbstractThis article aims to investigate the missiological development and conceptual understanding of “partnership in mission,” a major subject of inquiry through the history of the World Council of Churches (WCC), and to consider how ecumenical partners can enter into authentic friendship by embracing one another in the era of World Christianity. In ecumenical movements, the issue of the partner relationship has been illuminated through diverse missiological notions and themes based on profound reflections on missionary imperialism of the past. Since the 20th century, partnership in mission has provided a crucial practical and strategic framework for repositioning the unequal relationships between global South countries, as well as between the global North and South. Tracing a genealogy of partnership of the WCC, this paper discusses its deeper significance as “sharing life” articulated in the terminology of the Ecumenical Sharing of Resources (ESR). Furthermore, it proposes a model of “partnership in mission as incarnation” by relating debates about the ESR to God’s incarnation and crucifixion.
Belief in a Liminal State of Health: A Christological Review of In the Name of Jesus! Healing in the Age of HIV
Authors: Soko‐de Jong Thandi 
Published: November 2018

AbstractThis article examines the Ecumenical HIV and AIDS Initiative in Africa publication In the Name of Jesus! Healing in the Age of HIV by discussing some of the issues of faith that are at the core of healing in relation to HIV. This publication challenges Christian beliefs and faith‐healing practices that deter people from adhering to anti‐retroviral therapy (ART). However, it does not adequately address the contextual “Jesus as Healer Christologies” that are among the reasons such beliefs and practices remain attractive and popular, even among those who have been adhering to ART for many years. This article argues that treatable but incurable health conditions such as HIV raise questions about what it means to be in the liminal space where one’s health is dependent on treatment. The article calls for more engagement with Jesus as Healer Christologies alongside activism in this liminal space and suggests that the doctrine of incarnation may provide some helpful ways of addressing some of the theological questions posed by liminality.