bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of postoperative haemoglobin variation on major cardiopulmonary complications in high cardiac risk patients undergoing anatomical lung resections
Authors: Patella Miriam , Mongelli Francesco , Minerva Eleonora Maddalena , Previsdomini Marco , Perren Andreas , Saporito Andrea , La Regina Davide , Gavino Lorenzo , Inderbitzi Rolf , Cafarotti Stefano 
Published: July 2019

Abstract

OBJECTIVES
Recent evidence shows that permissive anaemia strategies are safe in different surgical settings. However, effects of variations in haemoglobin (Hb) levels could have a negative impact in high-risk patients. We investigated the combined effect of postoperative Hb concentration and cardiac risk status on major cardiopulmonary complications after anatomical lung resections.

METHODS
We retrospectively analysed the records, collected in a prospective clinical database, of 154 consecutive patients undergoing anatomical lung resections at our institution (February 2017–February 2019). Hb levels were displayed as preoperative concentration, nadir Hb level before onset of complications and delta Hb (ΔHb). Cardiac risk was stratified according to the Thoracic Revised Cardiac Risk Index (ThRCRI). Univariable and multivariable logistic regression analyses were used to test the associations between patients, surgical variables and cardiopulmonary complications according to the European Society of Thoracic Surgeons definitions.

RESULTS
Cardiopulmonary complications occurred in 63 patients (17%). In the fully adjusted multivariable model, higher values of ΔHb were associated with increased risk of complications [odds ratio (OR) 1.07; P < 0.001], along with higher ThRCRI classes (classes A–B versus C–D: OR 0.09; P < 0.001). Interaction terms with transfusion were not statistically significant, indicating that the harmful effect of ΔHb was independent. According to receiver operating characteristic curve analysis, a ΔHb of 29 g/l was found to be the best cut-off value for predicting complications.

CONCLUSIONS
In our series, ΔHb, rather than nadir Hb, was associated with an increased risk of complications, particularly in patients with higher cardiac risk. Restrictive transfusion strategies should be carefully applied in patients undergoing lung resections and balanced according to individual clinical status.
A study on CO2 absorption using hybrid solvents in packed columns
Authors: Kumar Ravinder , Ahmadi Mohammad Hossein , Rajak Dipen Kumar , Nazari Mohammad Alhuyi 
Published: July 2019

Abstract
Greenhouse gases emissions from large scale industries as well as gasoline based vehicles are mainly responsible for global warming since the 1980s. At present, it has triggered global efforts to reduce the level of GHG. The contribution of carbon dioxide (CO2) in polluting the environment is at a peak due to the excessive use of coal in power plants. So, serious attention is required to reduce the level of CO2 using advanced technologies. Carbon dioxide capture and storage may play an important role in this direction. In process industries, various carbon dioxide capture techniques can be used to reduce CO2 emissions. However, post-combustion carbon dioxide capture is on top priority. Nowadays the researcher is focusing their work on CO2 capture using hybrid solvent. This work highlights a review of carbon dioxide capture using various kind of hybrid solvent in a packed column. The various challenges for absorption efficiency enhancement and future direction are also discussed in the present work. It is concluded through the literature survey that hybrid solvent shows better efficiency in comparison to the aqueous solution used for CO2 capture.
On the Fourier Transform of Regularized Bessel Functions on Complex Numbers and Beyond Endoscopy Over Number Fields
Authors: Qi Zhi 
Published: July 2019

Abstract
In this article, we prove certain Weber–Schafheitlin-type integral formulae for Bessel functions over complex numbers. A special case is a formula for the Fourier transform of regularized Bessel functions on complex numbers. This is applied to extend the work of A. Venkatesh on Beyond Endoscopy for $\textrm{Sym}^2$ on $\textrm{GL}_2$ from totally real to arbitrary number fields.
The Contribution of the ILO’s International Labour Standards System to the European Court of Human Rights’ Jurisprudence in the Field of Non-Discrimination
Authors: Teklè Tzehainesh 
Published: July 2019

Abstract
This article examines the role played by International Labour Standards (ILS) of the International Labour Organisation (ILO) and the pronouncements of the ILO supervisory bodies in the development of the European Court of Human Rights (ECtHR)’s jurisprudence by focussing on the ECtHR’s case law on discrimination. This analysis is conducted against the background of the role that the ECtHR has been playing in making the European Convention of Human Rights (ECHR) an instrument that protects not only civil and political rights but also social and economic rights, and its consideration of the ECHR as a ‘living’ document. This study concludes with a reflection on the benefits of the ECtHR’s use of ILS and the work of the ILO supervisory bodies and challenges ahead.
Understanding profit margins of medical providers from prescription drugs: evidence from Taiwan
Authors:  Liu Ya-Ming 
Published: July 2019

Abstract

Background
This study empirically estimates the magnitude and associated determinants of profit margins that medical providers earn from prescription drugs based on Taiwan’s pharmaceutical market.

Methods
Our main data set is from the population-based claims data compiled by the National Health Insurance Research Database covering three waves of price adjustment: July–December 2004, October 2007–September 2008 and October 2009–September 2010. Only drugs whose reimbursement prices were adjusted using the R-zone formula were used as samples for this study. By calculating the difference between retail and wholesale prices for 796 pharmaceutical products, we can estimate the profit margin determinants using the regression model.

Results
We found evidence that suppliers of generic drugs tend to offer larger discounts to medical providers than suppliers of brand-name drugs. In addition, the countervailing power of wholesale pharmaceuticals, as measured by the discount rate offered by pharmaceutical manufacturers, is positively associated with the degree of competition within the pharmaceutical market and the size of the market itself.

Conclusions
Our findings imply that the profit-seeking behaviour exhibited by medical providers is the engine of competitive forces in Taiwan’s prescription drug market. This creates financial incentives for them, which in turn influences their choices of prescription drugs.
Does involving male partners in antenatal care improve healthcare utilisation? Systematic review and meta-analysis of the published literature from low- and middle-income countries
Authors: Suandi Dedih , Williams Pauline , Bhattacharya Sohinee 
Published: July 2019

Abstract

Background
Although in most low- and middle-income countries (LMICs) men are decision makers and control the household budget, their involvement in maternity care is limited. Reports from high-income countries indicate a beneficial effect of involving men in antenatal and delivery care on birth outcomes.

Methods
We conducted a systematic review to assess whether similar effects are observed in LMICs. We searched MEDLINE, PubMed, CINAHL, Embase, NCBI, PsycInfo and other relevant databases using a comprehensive search strategy to retrieve relevant articles. A total of 17 articles were included. Meta-analysis of extracted data was performed, using the generic inverse variance method where possible. All studies were conducted in South Asia and Africa.

Results
We found that involving a male partner in antenatal care was associated with skilled birth attendance utilization (pooled OR 3.19 [95% CI 1.55 to 6.55]), having institutional delivery (OR 2.76 [95% CI 1.70 to 4.50]) and post-partum visit uptake (OR 2.13 [95% CI 1.45 to 3.13]). Mother’s knowledge of danger signs and modern contraception utilization were also positively affected. However, it had no significant impact on the number of antenatal visits.

Conclusions
Male involvement in antenatal care had a positive impact on the uptake of maternal health services. Further research needs to investigate whether this translates into improved maternal and newborn health in developing countries.
The effect of migration and the hukou registration system on psychosocial domains and family functioning of children in Shanghai, China
Authors: Wang Jian , Gu Shenbing , Ye Bo , Gao Junling , Wang Fan , Dai Junming , Fu Hua 
Published: July 2019

Abstract

Background
According to the 2017 China National Education Development Statistics Bulletin, there were 14.07 million rural–urban migrant children in the compulsory education stage. The mental health of migrant children in China has drawn increasing attention in research. The objective of this study was to compare subjective well-being, self-esteem, prosocial behaviour and family functioning of migrant children vs local children in Shanghai and to explore their relationship.

Methods
A survey was conducted among 2229 students (9–17 y of age; male 52.0%, female 48.0%) and their parents from grades 4 to 8 in four primary schools and four middle schools in Shanghai in 2016. The sample consisted of 1333 migrant children and 896 urban children in three migrant schools and five public schools. A total of 959 rural–urban migrant children and 374 urban hukou migrant children were recruited. The questionnaire for students included the Personal Well-Being Index – School Children (PWI-SC), Satisfaction with Life Scale (SWLS), Positive and Negative Affect Scale for Children, Rosenberg Self-Esteem Scale, Family APGAR Index and prosocial behaviour domain of the Strengths and Difficulties Questionnaire. In the questionnaire for parents, the Personal Well-Being Index and Social Support Rating Scale were used in addition to the sociodemographic characteristics. These data were analysed using one-way analysis of variance, correlation analysis and multiple linear regression.

Results
Rural–urban migrant children reported significantly lower PWI-SC, SWLS, positive affect, prosocial behaviour, self-esteem and Family APGAR Index scores and reported higher negative affect scores than local children (p<0.01). The prevalence rate of abnormal prosocial behaviour among rural–urban migrant children was 10%, which was higher than that of local children (5.9%; p<0.001). Compared with rural–urban migrant children in public schools, the SWLS, prosocial behaviour and Family APGAR Index scores of the children in migrant schools were higher and the prevalence rate of abnormal prosocial behaviour was lower (p<0.01). Multiple linear regression analysis indicated that the self-esteem and Family APGAR Index had predictive effects on subjective well-being and prosocial behaviour scores of rural–urban migrant children.

Conclusions
Rural–urban migrant children are susceptible to mental health problems. Additional public policy and interventions by practitioners are needed to support rural–urban migrant children.
Switching to bictegravir/emtricitabine/tenofovir alafenamide maintained HIV-1 RNA suppression in participants with archived antiretroviral resistance including M184V/I
Authors: Andreatta Kristen , Willkom Madeleine , Martin Ross , Chang Silvia , Wei Lilian , Liu Hui , Liu Ya-Pei , Graham Hiba , Quirk Erin , Martin Hal , White Kirsten L 
Published: July 2019

AbstractObjectivesStudies 1878 and 1844 demonstrated non-inferior efficacy of switching suppressed HIV-1-infected adults to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) versus continuing boosted PI-based triple regimens or dolutegravir/abacavir/lamivudine (DTG/ABC/3TC). Here, detailed analyses of pre-existing resistance in the two BIC/FTC/TAF switch studies and efficacy at week 48 are described.MethodsPre-existing resistance was assessed from historical genotypes (documented resistance to study drugs was excluded) and by retrospective baseline proviral archive DNA genotyping from whole blood. Outcomes were based on HIV-1 RNA at week 48 with missing values imputed using the last on-treatment observation carried forward method.ResultsCumulative pre-existing resistance data from historical and proviral genotypes were obtained for 95% (543/570) of participants who switched to BIC/FTC/TAF. Altogether, 40% (217/543) had one or more pre-existing primary resistance substitutions in protease, reverse transcriptase and/or integrase. Pre-switch NRTI resistance was detected in 16% (89/543) of BIC/FTC/TAF-treated participants, with M184V or M184I detected by proviral genotyping in 10% (54/543). At week 48, 98% (561/570) of all BIC/FTC/TAF-treated participants versus 98% (213/217) with pre-existing resistance and 96% (52/54) with archived M184V/I had HIV-1 RNA <50 copies/mL. No BIC/FTC/TAF-treated participants developed treatment-emergent resistance to study drugs.ConclusionsPre-existing resistance substitutions, notably M184V/I, were unexpectedly common among suppressed participants who switched to BIC/FTC/TAF. High rates of virological suppression were maintained in the overall study population and in those with pre-existing resistance, including M184V/I, for up to 48 weeks of BIC/FTC/TAF treatment with no resistance development. These results indicate that BIC/FTC/TAF is an effective treatment option for suppressed patients, including those with evidence of archived NRTI resistance.
An unexpectedly high occurrence of aciclovir-induced neuropsychiatric symptoms in patients treated for herpesvirus CNS infection: a prospective observational study
Authors: Lindström Johan , Helldén Anders , Lycke Jan , Grahn Anna , Studahl Marie 
Published: July 2019

Abstract

Background
Aciclovir is effective in herpesvirus infections of the CNS. Aciclovir-induced neuropsychiatric symptoms (AINS) have been reported and are associated with high CSF concentrations of aciclovir metabolite 9-carboxymethoxymethylguanine (CMMG). Risk factors except for renal failure have not been explored, and disruption of the blood–brain barrier (BBB) in acute CNS infection may be of interest.

Objectives
To investigate the impact of risk factors on aciclovir and CMMG concentrations, and to relate the results to AINS.

Methods
We investigated 21 consecutively included, consenting patients treated with aciclovir or valaciclovir for herpesvirus CNS infection. Regression models were constructed to study the impact of risk factors including BBB disruption, as measured with CSF:serum albumin ratio, on CSF aciclovir and CMMG concentrations. Medical records were assessed retrospectively to identify patients with AINS.

Results
Increased CSF:serum albumin ratio, as well as decreased renal function and high aciclovir doses, was associated with increased aciclovir and CMMG concentrations in the CSF. We identified five patients with new neuropsychiatric symptoms; four of those were considered to have AINS and had increased CSF CMMG concentrations. Only one patient without suspicion of AINS had an increased CSF CMMG concentration.

Conclusions
In patients with herpesvirus CNS infections, BBB disruption is associated with increasing aciclovir and CMMG CSF concentrations. We also found an unexpectedly high number of patients with AINS. Evaluation of CSF:serum albumin ratios, renal function and CSF concentrations of aciclovir and CMMG may all contribute to the optimization of aciclovir dosing and avoidance of AINS.
Prognostic models will be victims of their own success, unless…
Authors: Lenert Matthew C , Matheny Michael E , Walsh Colin G 
Published: July 2019

AbstractPredictive analytics have begun to change the workflows of healthcare by giving insight into our future health. Deploying prognostic models into clinical workflows should change behavior and motivate interventions that affect outcomes. As users respond to model predictions, downstream characteristics of the data, including the distribution of the outcome, may change. The ever-changing nature of healthcare necessitates maintenance of prognostic models to ensure their longevity. The more effective a model and intervention(s) are at improving outcomes, the faster a model will appear to degrade. Improving outcomes can disrupt the association between the model’s predictors and the outcome. Model refitting may not always be the most effective response to these challenges. These problems will need to be mitigated by systematically incorporating interventions into prognostic models and by maintaining robust performance surveillance of models in clinical use. Holistically modeling the outcome and intervention(s) can lead to resilience to future compromises in performance.
Cannabinoid Stability in Antemortem and Postmortem Blood
Authors: Meneses Vanessa , Mata Dani 
Published: July 2019

Abstract
In toxicological testing, drug stability is important when providing quantitative results and interpretation of findings, as well as when collecting correlation data. The goal of this study was to expand on previous stability studies and to evaluate other cannabinoids encountered in forensic toxicology. In this 6-month study, the stability of Δ-9-tetrahydrocannabinol (THC), 11-hydroxy-THC, 11-nor-9-carboxy-THC, Cannabinol and Cannabidiol in antemortem and postmortem blood was evaluated in refrigerated (4°C) and frozen (−4°C) storage conditions. Pooled antemortem and postmortem bloods were fortified at low and high concentrations and stored in untreated glassware. Over 6 months, samples were analyzed by automated extraction and liquid chromatography-mass spectrometry/mass spectrometry to evaluate the change in concentration over time. Samples in each storage condition were analyzed in triplicate 12 times over the 6-month period. Cannabinoids in antemortem blood were more stable in the refrigerated condition than in the frozen condition, with 11-hydroxy-THC, 11-nor-9-carboxy-THC and Cannabinol having more than 80% of the original concentration remaining at the end of the study. Cannabinoids in postmortem blood had improved stability in the frozen storage condition with THC, 11-hydroxy-THC, 11-nor-9-carboxy-THC and Cannabinol in the low concentration pool with more than 80% of the original concentration remaining. These data demonstrated that cannabinoids may decrease in concentration over time when stored in untreated glass vials. To ensure the most accurate determination of drug concentration, samples containing cannabinoids should be analyzed as soon as possible.
Acidic Drug Concentrations in Postmortem Vitreous Humor and Peripheral Blood
Authors: Hubbard Jacqueline A , Navarrete Aylmer L , Fitzgerald Robert L , McIntyre Iain M 
Published: July 2019

Abstract
Vitreous humor is a potential alternative matrix for postmortem toxicology drug screens when peripheral blood is unavailable. It is easily and reliably collected and may not suffer from the same postmortem redistribution as seen in blood. Here, we compared the concentrations of 7 acidic drugs (acetaminophen, ibuprofen, naproxen, salicylic acid, carbamazepine, phenobarbital and phenytoin) in peripheral blood and vitreous fluid collected in 89 autopsy cases. Analysis was done by high-performance liquid chromatography with diode-array detection. Overall, we found that vitreous drug concentrations were significantly lower than peripheral blood with median vitreous to peripheral blood (V/PB) ratios ranging from 0.0 to 0.6 (mean, 0.1–0.6). The correlations between the concentrations of over-the-counter analgesics in peripheral blood versus vitreous fluid were poor, with acetaminophen exhibiting the best linearity (R2 = 0.72). The antiepileptic drugs (carbamazepine, phenytoin and phenobarbital) exhibited good correlations between peripheral blood and vitreous humor, with all exhibiting an R2 ≥ 0.95. Overall, we have demonstrated the potential of vitreous fluid as an alternative matrix for the detection of select acidic drugs.
MicroRNA-449b-5p suppresses cell proliferation, migration and invasion by targeting TPD52 in nasopharyngeal carcinoma
Authors: Yin Wei , Shi Lei , Mao Yanjiao 
Published: July 2019

Abstract
Nasopharyngeal carcinoma (NPC) is an important type of head and neck malignant cancer with geographical distribution. MicroRNA-449b-5p (miR-449b-5p) is related to the development of various cancers, while its function in NPC remains unknown. The present study aimed to investigate the role and target gene of miR-449b-5p in NPC. Expressions of miR-449b-5p in NPC cell lines and clinical tissues were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation was determined by MTT and colony formation assays. Migration and invasion abilities after different treatment were evaluated by wound healing and Transwell assays, respectively. Dual-luciferase reporter assay was performed to explore the relationship between miR-449b-5p and tumour protein D52 (TPD52). TPD52 expression was determined by qRT-PCR and western blot assay. miR-449b-5p was significantly downregulated in NPC cell lines and clinical tissues than the matched control. Overexpression of miR-449b-5p inhibited proliferation, migration and invasion of NPC cells. Dual-luciferase reporter assay indicated that miR-449b-5p directly targeted TPD52. Furthermore, shRNA-mediated downregulation of TPD52 rectified the promotion of cell migration and invasion by miR-449b-5p inhibition. In conclusion, the present study suggests that miR-449b-5p, as a novel tumour-suppressive miRNA against NPC, inhibits proliferation, migration and invasion of NPC cells via inhibiting TPD52 expression.
Genetic Variation in Anastrepha obliqua (Diptera: Tephritidae) in a Highly Diverse Tropical Environment in the Mexican State of Veracruz
Authors: Ruiz-Arce Raul , Islam Md-Sajedul , Aluja Martin , McPheron Bruce A 
Published: July 2019

AbstractThere has been considerable interest in understanding biological, ecological, historical, and evolutionary processes that contribute to the diversification of species and populations among tephritid fruit flies. Only a limited number of studies have examined the genetic diversity and population biology of species belonging to the genus Anastrepha considering fine-scale differentiations associated to locality as well as hosts over an entire fruiting season. To expand our understanding of population structure and genetic diversity in one of the critical Anastrepha fruit flies populations in a highly diverse tropical environment we analyzed Anastrepha obliqua (Macquart) (Diptera: Tephritidae) in the Mexican state of Veracruz from five host fruit species and 52 geographic collections using sequence data from mtDNA and microsatellite markers from nuclear DNA. Indeed, we examined the population structure of this pest in a micro-geographic region and report on relationships and historical processes for individuals collected within a small portion of the geographic range of its distribution. Analyses of 1055 bp mtDNA sequences from CO1and ND1genes across 400 individuals detected 34 haplotypes. Haplotype and nucleotide diversity was low, with 53% of the individuals exhibiting a single haplotype (OBV1). Host association and fine-scale differentiation at 17 microsatellite markers across 719 individuals from 32 of the 52 geographic collections reveal fragmented A. obliqua populations. These findings have important implications for the implementation of the Sterile Insect Technique (SIT) and other pest management programs used to control this pestiferous fruit fly.