bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of bicuspid aortic valve by echocardiography
Authors: Jain Renuka , Ammar Khawaja Afzal , Kalvin Lindsey , Ignatowski Denise , Olet Susan , Tajik A. Jamil , Khandheria Bijoy K. 
Published: October 2018

BackgroundEchocardiography is regarded as the gold standard for diagnosis of bicuspid aortic valve (BAV), yet diagnostic accuracy has been evaluated previously only in single‐center studies. We systematically evaluated the accuracy of BAV diagnosis in a large healthcare system of multiple echocardiography laboratories.Methods and ResultsAurora Health Care is a multihospital, multi‐clinic system across the state of Wisconsin encompassing 33 inpatient and outpatient echocardiography laboratories with 39 cardiologist readers and 72 sonographers. As all laboratories store echocardiograms in one database, we queried all patients with “bicuspid aortic valve” diagnosis on echocardiography. Echocardiograms were classified as “BAV” or “possible BAV” based on initial reader confidence. An expert review panel categorized each as BAV, no BAV, or Indeterminate. Of the 745 cases identified, 589 (79.1%, initial reader interpretation: n = 494 “BAV,” n = 95 “possible”) were BAV. A high level of agreement (84%) was present in BAV diagnosis. There were 156 (20.9%) echocardiograms that were no BAV (8.4%) or Indeterminate (12.4%). We identified three common reasons for misdiagnosis: poor image quality (n = 70, 44.9%), leaflet calcium (n = 44, 28.2%), and oblique axis imaging (n = 33, 21.1%). A clear reason for misclassification was not elucidated in nine cases (n = 9, 5.7%).ConclusionsThis is the first study to evaluate BAV accuracy across a community health system with multiple echocardiography laboratories and a heterogeneous group of readers and sonographers. We establish a high degree of accuracy of echocardiography in BAV diagnosis and draw attention to common echocardiographic pitfalls that lead to BAV misclassification, highlighting opportunities for education and quality improvement.
Presence and viability of Ceratocystis lukuohia in ambrosia beetle frass from Rapid ʻŌhiʻa Death‐affected Metrosideros polymorpha trees on Hawaiʻi Island
Authors: Roy Kylle , Ewing Curtis P. , Hughes Marc A. , Keith Lisa , Bennett Gordon M. 
Published: October 2018

AbstractRapid ʻŌhiʻa Death (ROD) is a fungal disease of ʻōhiʻa lehua (Myrtaceae: Metrosideros polymorpha) caused by Ceratocystis lukuohia and C. huliohia. ROD is the aetiological agent of widespread mortality of this important tree on Hawaiʻi Island, but its epidemiology remains unclear. We investigated the prevalence and viability of C. lukuohia in ambrosia beetle frass in ROD‐affected ʻōhiʻa trees. A total of 200 frass traps were placed onto C. lukuohia‐infected ʻōhiʻa at four locations on the east side of Hawaiʻi Island. Frass was collected and screened for the presence of C. lukuohia DNA using a diagnostic qPCR assay. In addition, frass samples were screened for viability by carrot baiting. All trapped beetles were of the genus Xyleborus, with the majority being the non‐native X. ferrugineus. Of the frass samples tested, 62% contained C. lukuohia DNA and 17% of carrot baits were positive for the fungus. These results indicate that ambrosia beetle frass releases C. lukuohia into the environment. We discuss the potential role infested frass could play in the ROD pathosystem.
Tumour deposits are a significant prognostic factor in gastric cancer – a systematic review and meta‐analysis
Authors: Graham Martínez Cristina , Knijn Nikki , Verheij Marcel , Nagtegaal Iris D , van der Post Rachel S 
Published: October 2018

AimsTumour deposits (TDs) are clusters of cancer cells in the soft tissue that are discontinuous from the primary tumour. In this review we are exploring their relevance for prognosis in patients with gastric cancer.Methods and resultsA literature search was performed to identify studies providing data on TDs and prognosis in gastric cancer patients. Eight papers were included in the meta‐analysis, which was carried out in terms of risk ratios (RR) and hazard ratios (HR) with 95% confidence interval (95% CI). Of 7445 patients, 1551 had TDs (20.9%). TDs were associated with a decreased overall survival (OS) in univariate (HR = 2.82, 95% CI = 1.9–4.3) and multivariate analyses (HR = 1.65, 95% CI = 1.3–2.1). TDs were also associated with known prognostic factors such as synchronous metastatic disease (RR = 9.5), invasion depth (RR = 1.8), lymph node metastasis (RR = 1.7), lymphatic invasion (RR = 1.7), vascular invasion (RR = 2.6) and poor differentiation (RR = 1.2).ConclusionsWe found a strong indication that TDs are independent predictors of prognosis in patients with gastric cancer; hence, TDs should be included in the staging of gastric cancers.
Expression of odorant‐binding proteins in mouthpart palps of the desert locust Schistocerca gregaria
Authors: Pregitzer P. , Zielonka M. , Eichhorn A.‐S. , Jiang X. , Krieger J. , Breer H. 
Published: October 2018

AbstractOdorant‐binding proteins (OBPs) are essential molecular elements of the insect chemosensory system, which is composed of the antennae and the mouthpart palps (maxillary and labial). In this study, we have analysed the expression and the sensilla specificity of 14 OBP subtypes in the palps of the desert locust Schistocerca gregaria. The locust palps comprise only a low number of sensilla basiconica but a high number of sensilla chaetica. Employing a variety of approaches, we found that only a subset of the antennal OBP repertoire was expressed in both palp types. These OBPs were previously shown to be expressed either in sensilla basiconica or sensilla chaetica of the antennae. Comparing the expression pattern in the two chemosensory organs revealed similarities and differences; most remarkably, two OBP subtypes, OBP6 and OBP8, were found in both sensilla types on palps, whereas on the antennae they were solely expressed in one sensillum type. Together, the data indicate a differential, but partly overlapping, expression of OBPs in the two sensilla types of the palps. The differences in the expression pattern of OBP subtypes between antennae and palps might be indicative for distinct functions of the OBPs in the two chemosensory organs.
Early Symptom Measurement of Post‐Stroke Depression: Development and validation of a new short version
Authors: Li Jufang , Li Yun , Li Ping , Ye Maiyun 
Published: October 2018

AbstractAimsThe aim of this study was to develop and test the psychometric properties of the Early Symptom Measurement of Post‐Stroke Depression‐Short Form (ESMPSD‐SF).BackgroundThe ESMPSD is a specific measurement tool designed to detect early depressive symptoms in acute stroke patients, but it is too long for use in busy clinical settings.DesignA psychometric study was conducted.MethodsFive hundred and twenty‐one post‐stroke patients completed two questionnaires, the demographic and the ESMPSD questionnaire, over a period of 10 months, from July 2016–April 2017. The item reduction process was used to reduce the number of items in the ESMPSD questionnaire and consisted of item analysis, exploratory, and confirmatory factor analysis.ResultsThe item reduction process resulted in a 12‐item short version questionnaire with evidence of acceptable construct validity and internal reliability. Four factors explaining high total variance were extracted: “low,” “guilt,” “emotional,” and “wakefulness”. Estimates of all confirmatory model fit indices met the standard criteria. All standardized factor loading estimates of the 12 items met the standard criteria and the variances explained by the items were acceptable. Moreover, internal reliability estimates of the 12‐item questionnaire were acceptable, and the corrected item‐total correlation and item‐subscale correlation also demonstrated evidence of acceptable reliability of the short form questionnaire.ConclusionsThe ESMPSD‐SF demonstrates evidence of acceptable reliability and validity to screen early depressive symptoms in acute stroke patients in busy clinical settings.
Nausea intensity as a reflector of early physical recovery after surgery
Authors: Eriksson Kerstin , Årestedt Kristofer , Broström Anders , Wikström Lotta 
Published: October 2018

AbstractAimTo compare different levels of self‐rated average nausea intensity with early physical recovery and determine if nausea can reflect recovery in patients undergoing general or orthopaedic surgery.BackgroundNausea has been found to influence postoperative physical recovery. Despite the incidence of nausea in postoperative care, there is a knowledge gap about the possibility of using average nausea intensity to reflect recovery, motivating further investigation.DesignAn observational design with repeated measures.MethodsGeneral and orthopaedic patients answered a questionnaire (October 2012–January 2015) about nausea and impact on recovery on postoperative days 1 (N = 479) and 2 (N = 441). Questions about average nausea intensity at rest and during activity were answered based on the Numeric Rating Scale (NRS) (0–10). Impact on recovery was evaluated using three dimensions from the postoperative recovery profile tool.ResultsAbout one‐fifth of the patients reported nausea intensity as moderate to severe on days 1 and 2. Nausea intensity was associated with eight of nine aspects of recovery on postoperative day 1. Nausea intensity on day 1 also reflected four of nine aspects of recovery on day 2. About reflecting physical recovery, the association was strongest between nausea intensity and appetite changes.ConclusionsAs postoperative nausea is common, regular assessments by healthcare professionals are needed. Assessment of nausea is of importance since it reflects physical recovery. This also shows the importance of treating nausea without delay. Using the NRS to measure nausea intensity is a simple method that is easy to use in clinic.
Intentional rounding – An integrative literature review
Authors: Ryan Liz , Jackson Debra , Woods Cindy , Usher Kim 
Published: October 2018

AbstractAimsTo establish current knowledge about the efficacy and acceptance of intentional rounding in current practice, from the perspective of nurses, patients, patient satisfaction and safety indicators.BackgroundIntentional rounding is a formal means of nursing staff checking care needs of patients in hospital settings on a regular basis.DesignAn integrative literature review conducted following the Joanna Briggs Institute manual.Data sourcesA literature search from 2000 – 2017 was conducted using the following electronic databases: The Cumulative Index to Nursing and Allied Health Literature, ProQuest, PubMed, Informit, Sage and Scopus.Review methodsArticles were assessed for quality and rigor using the Critical Appraisal Skills Program tool and the Effective Public Health Practice Project Quality Assessment tool for Quantitative Studies. A sequential explanatory mixed studies approach was used to combine qualitative and quantitative evidence in a single review. In‐depth parallel reviews of the quantitative and qualitative evidence were undertaken, and then a synthesis of the combined qualitative and quantitative evidence conducted.ResultsIntentional rounding has positive outcomes on patient satisfaction and safety. Nurses perceive benefits related to intentional rounding; however, some nurses perceive it as an additional, unnecessary task. The effectiveness of intentional rounding is influenced by external factors including leadership and formal rounding education, workload, ward layout, staffing and experience level.ConclusionIntentional rounding is a positive intervention in patient safety and satisfaction generally, but needs further research and consideration about actual impact, staff delegation, education and engagement, student nurse involvement, documentation and specializing the structure of intentional rounding.
Nurses working in intellectual disability‐specific settings talk about the uniqueness of their role: A qualitative study
Authors: Wilson Nathan J. , Wiese Michele , Lewis Peter , Jaques Hayden , O'Reilly Kate 
Published: October 2018

AbstractAimsTo explore the perceptions of Australian nurses working in disability‐specific settings and/or roles, about: (a) nursing people with intellectual and developmental disability living in Sydney; and (b) the utility and applicability of professional practice standards designed specifically for intellectual and developmental disability nursing.DesignA qualitative research design was used to guide the study and our analysis utilized the constant comparative approach to thematic data analyses.MethodsIndividual in‐person interviews were conducted with 18 nurses working in intellectual and developmental disability‐specific settings and/or roles across the state of New South Wales between July – December, 2017. Participants described what it is that sets intellectual and developmental disability nursing apart from other nursing specialties, and the rewards and challenges of their role. Questions were also asked about professional practice standards in general and more specifically intellectual and developmental disability professional practice standards. Data were analysed thematically.FindingsThree themes reflected intellectual and developmental disability nurses’ perceptions: (a) a unique investment in the nurse/patient dyad; (b) a bridge between disparate systems; and (c) an ambiguous future. Nurses reported variable understanding of professional practice standards designed for intellectual and developmental disability nursing, but also a belief in their importance.ConclusionThe intellectual and developmental disability nurses’ experience of care accounts for the specific needs of patients with intellectual and developmental disability and suggests the importance of professional practice standards which acknowledge the changing landscape of care in Australia prompted by the implementation of the National Disability Insurance Scheme.
Factors influencing patient delay in individuals with haemorrhoids: A study based on theory of planned behavior and common sense model
Authors: Shi Ying , Yang Dongliang , Chen Si , Wang Shouqi , Li Huanhuan , Ying Jie , Zhang Meiling , Li Yuan , Xing Zhuangjie , Sun Jiao 
Published: October 2018

AbstractAimsThis study aimed to describe the status of patient delay and examine related factors affecting patient delay in individuals with haemorrhoids in mainland China, based on theory of planned behaviour and common sense model.BackgroundStudies on patient delay have mainly focused on cancer, tuberculosis and myocardial infarction, but studies on patient delay in individuals with haemorrhoids have yet to be conducted. Compared with other diseases, haemorrhoids are initially considered benign. However, if patients with haemorrhoids seek delayed medical assistance, they pay a large cost for worse symptoms because they fail to seek timely treatments compared with those who receive appropriate treatments at early stages.DesignA cross‐sectional study design was used.MethodsThe current study was performed on 306 patients with haemorrhoids from June ‐ October 2017. Data were collected via a self‐administered pencil‐and‐paper survey that consisted of a multi‐item questionnaire. Stepwise logistic regression analysis was conducted to explore the factors of patient delay.ResultsMiddle‐aged participants were more than twice more likely to report patient delay than participants in other age groups. A high level of perceived self‐efficacy, a high level of illness perceptions and perceived social impact were associated with prolonged delay.ConclusionThis study showed that patient delay is common among patients with haemorrhoids in China. The influencing factors of patient delay were middle‐aged, illness perceptions, perceived self‐efficacy, and perceived social impact.
Is adenosine useful for the identification of atrial fibrillation triggers?
Authors: Tutuianu Cristina , Pap Robert , Riesz Tamas , Bencsik Gabor , Makai Attila , Saghy Laszlo 
Published: October 2018

AbstractIntroductionBoth isoproterenol (Iso) and adenosine (Ado) are used to induce atrial fibrillation (AF) in the electrophysiology lab. However, the utility of Ado has not been systematically established.ObjectiveThe purpose of this study was to compare Ado to Iso for the induction of paroxysmal AF.MethodsForty patients (16 women; mean age, 60 ± 12 years) with paroxysmal AF, presenting for ablation were prospectively included of whom 36 (90%) received Ado (18‐36 mg) and/or Iso (3‐20 µg/min incremental dose) in a randomized order (26 [72%] received both drugs).ResultsAF was induced with Iso in 15 of 32 (47%) and with Ado in 12 of 30 (40%) patients (P = 0.9). Iso‐triggered AF started from the left pulmonary veins (PVs) in 11 of 15 (73%), from the right PVs in 3 of 15 (20%), and from the coronary sinus (CS) in 1 of 15 (7%) cases. Ado‐induced AF episodes originated from the left PVs in 6 of 12 (50%), from the right atrium (RA) in 4 of 12 (33%), and from the CS in 2 of 12 (17%) cases. Altogether, Iso‐induced AF was more likely initiated from the PVs (93%) compared with Ado (50%) (
P = 0.02). Ado‐induced non‐PV triggers were not predictive of arrhythmia recurrence after PV isolation.ConclusionAdo much more frequently induces non‐PV triggers, especially from the RA. The clinical significance of these foci, however, is questionable.
Cardioversion of atrial fibrillation in obese patients: Results from the Cardioversion‐BMI randomized controlled trial
Authors: Voskoboinik Aleksandr , Moskovitch Jeremy , Plunkett George , Bloom Jason , Wong Geoffrey , Nalliah Chrishan , Prabhu Sandeep , Sugumar Hariharan , Paramasweran Ramanathan , McLellan Alex , Ling Liang‐Han , Goh Cheng‐Yee , Noaman Samer , Fernando Himawan , Wong Michael , Taylor Andrew J. , Kalman Jonathan M. , Kistler Peter M. 
Published: October 2018

AbstractAimsObesity is associated with higher electrical cardioversion (ECV) failure in persistent atrial fibrillation (PeAF). For ease‐of‐use, many centers prefer patches over paddles. We assessed the optimum modality and shock vector, as well as the safety and efficacy of the Manual Pressure Augmentation (MPA) technique.MethodsPatients with obesity (BMI ≥ 30) and PeAF undergoing ECV using a biphasic defibrillator were randomized into one of four arms by modality (adhesive patches or handheld paddles) and shock vector (anteroposterior [AP] or anteroapical [AA]). If the first two shocks (100 and 200 J) failed, then patients received a 200‐J shock using the alternative modality (patch or paddle). Shock vector remained unchanged. In an observational substudy, 20 patients with BMI of 35 or more, and who failed ECV at 200 J using both patches/paddles underwent a trial of MPA.ResultsIn total, 125 patients were randomized between July 2016 and March 2018. First or second shock success was 43 of 63 (68.2%) for patches and 56 of 62 (90.3%) for paddles (P = 0.002). There were 20 crossovers from patches to paddles (12 of 20 third shock success with paddles) and six crossovers from paddles to patches (three of six third shock success with patches). Paddles successfully cardioverted 68 of 82 patients compared with 46 of 69 using patches (82.9% vs 66.7%;
P = 0.02). Shock vector did not influence first or second shock success rates (82.0% AP vs 76.6% AA;
P = 0.46). MPA was successful in 16 of 20 (80%) who failed in both (patches/paddles), with 360 J required in six of seven cases.ConclusionRoutine use of adhesive patches at 200 J is inadequate in obesity. Strategies that improve success include the use of paddles, MPA, and escalation to 360 J.
Methyl eugenol effects on Bactrocera dorsalis male total body protein, reproductive organs and ejaculate
Authors: Reyes‐Hernández Martha , Thimmappa Raghava , Abraham Solana , Pagadala Damodaram Kamala Jayanthi , Pérez‐Staples Diana 
Published: October 2018

AbstractMethyl eugenol (ME) and inclusion of protein into the adult diet increase the mating competitiveness of the Oriental fruit fly, Bactrocera dorsalis (Hendel). Exposing males to ME or protein is a promising post‐teneral treatment for males being released in the sterile insect technique (SIT). However, the effect of this post‐teneral treatment on male reproductive organs or the male ejaculate is unknown. During mating, males transfer sperm and accessory gland products (AGPs) to females and these compounds are reported to modulate female sexual inhibition. We studied the impact of male exposure to ME and a yeast hydrolysate (YH) diet on the protein reserves of males, male reproductive organ size, and the male ejaculate through sperm and AGPs. We show that males exposed to ME regardless of access to YH accumulated a greater amount of whole body protein. Males fed on YH also had increased total body protein and had bigger reproductive organs than YH‐deprived males, but no apparent effect of ME exposure was observed on reproductive organ size. Females stored less sperm when mated with males fed on YH and ME compared to males not fed on ME. YH and ME had no effect on male AGPs. Females injected with AGPs of males fed on YH and exposed to ME were just as likely to mate as females injected with AGPs of non‐treated males. However, females injected with AGPs of males exposed to ME mated faster than females injected with AGPs of non‐exposed males. We conclude that while exposure to ME increases male copulatory success and protein reserves in the male body, there seem to be some potential trade‐offs such as lower sperm stored by females. We discuss our results in terms of pre‐release protocols that may be used for B. dorsalis in SIT application.
Depth of cure of bulk fill resin composites: A systematic review
Authors: Lima Renally Bezerra Wanderley , Troconis Cristhian Camilo Madrid , Moreno Marina Barrêto Pereira , Murillo‐Gómez Fabián , De Goes Mario Fernando 
Published: October 2018

ABSTRACTObjectiveTo evaluate scientific evidence regarding depth of cure of bulk‐fill resin composites (BFRCs) and related factors.Material and MethodsPubMed/Medline, Embase, Scopus, and ISI Web of Science databases were accessed from October 2016 to May 2017. Investigations published in English language, assessing depth of cure of BFRCs by microhardness test and/or degree of conversion (DC) were included. Studies using exclusively ISO 4049, employing specimens deepness less than 4 mm, as well as those not reporting exposure time and/or irradiance from light curing units (LCUs) were excluded.ResultsIn total, 742 studies were found from which 33 were included. From 21 studies evaluating BFRCs microhardness, 10 showed acceptable bottom/top ratios (≥0.8) for all tested materials. However, material‐dependent results and non‐satisfactory bottom/top microhardness ratios (<0.8) were reported in 9 and 2 investigations, respectively. From 19 studies that assessed DC, 11 showed acceptable results (≥50%) for all tested BFRCs, while 8 studies reported material‐dependent outcomes. Overall, irradiance from LCUs ranged from 650 to 1330 mW/cm2 and exposure time from 5 to 60 seconds. Favorable depth of cure results were observed with the use of LCUs emitting irradiance ≥1000 mW/cm2 and exposure times ≥20 seconds.ConclusionsHigh depth of cure rates by BFRCs, depends on some factors as material, irradiance and exposure time. Polywave LCUs were useful but not essential on polymerizing alternative photoinitiator‐containing BFRC.Clinical SignificanceLED curing devices (polywave or monowave) displaying an irradiance ≥1000 mW/cm2 and 20 seconds of exposure time are imperative to accomplish successful polymerization of most BFRCs.