bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manajemen Pendidikan Pada Masa Rasulullah Sampai Khulafau Rasyidin Dan Aplikasinya Di Era Millenial
Authors: Suheri  , Zaenuri  , Adindan Wiwik , Mahbub Ali Amum , Anshori Irfan 
Published: November 2024

Educational management that is currently developing contains many crucial problems so that a reflection of ideal educational management is needed. This research aims to find out and understand how education was managed during the time of the Prophet to the Rasyidin Khulafau; and its application in the current era. The method used in this research is a qualitative method. This type of research is descriptive qualitative. Data collection techniques were obtained through interviews and documentation analysis which was not measured by numbers. This research was carried out over a period of 6 months; starting from January 2024 to June 2024. The subjects of this research include students, lecturers and religious figures. Data analysis techniques use the Miles & Huberman model; includes data reduction, data presentation and drawing conclusions. The data validity technique used in this research is the triangulation technique. The results of this research are that someone who is in charge of education must have the characteristics of analyzing, planning, problem solving, predicting. Apart from that, you must also have good management characteristics, measurable targets, optimal processes and appropriate targets. The managerial reflection of the Prophet's time has been continued into the current millennial era; such as only a leader must have a good personality, understand the concept of Islamic education management, understand management strategies, have long-term Islamic education planning, have a strong determination in managing human resources, have the attitude of an educational organizer, have the qualities of a leader and education supervisor.
PEMBINAAN LITERASI KETERAMPILAN PEMUDA DALAM PENGEMBANGAN KEMANDIRIAN EKONOMI KREATIF
Authors: Isa Abd. Hamid , Anu Zulkarnain , Ibrahim Muhammad 
Published: November 2024

Provinsi Gorontalo termasuk dalam urutan ke 6 dari 10 daerah dengan jumlah penduduk miskin terbanyak pada September 2021 (BPS, Januari 2022), dengan jumlah penduduk miskin sebesar 15,41 persen dan Sulawesi Tengah di urutan ke 10 dengan presentasi penduduk miskin sebesar 12,18 persen. Sebaran wilayah penduduk miskin ternyata berada dalam wilayah Teluk Tomini. Program KKN Tematik oleh LPPM UNG Tahun 2024 diorientasikan untuk meningkatkan kualitas jumlah pengabdian dosen UNG. Dalam menunjang hal tersebut, maka salah satu program yang strategis dilakukan dalam Bentuk Kegiatan Pembelajaran (BKP) melalui pembinaan literasi pemuda dan bagi masyarakat desa sebagai upaya percepatan kemandirian ekonomi yang berdampak pada kesejahteraan masyarakat. Target program pembinaan literasi pemuda untuk mendukung pengembangan kemandirian ekonomi kreatif ini adalah terwujudnya masyarakat yang memiliki pengetahuan sebagai bagian dari proses pembelajaran serta memiliki keterampilan yang merupakan upaya peningkatan kesejahteraan melalui ketahanan ekonomi kreatif masyarakat.
Pengaruh Aplikasi Pojok Remaja terhadap Pengetahuan Remaja tentang Kesehatan Reproduksi di SMA Muhammadiyah 01 Medan
Authors: Syari Mila , Harahap Novy Ramini , Nasution Pratiwi , Rauda Rauda 
Published: November 2024

ABSTRACT Adolescents are a rental group that must be given information about reproductive health, adolescents who are an active group using the Internet can be used to use the application to obtain information about adolescent health, 34.5% of adolescents are boys and 33.3% of adolescent girls start dating who have sexual intercourse and transmit sexual diseases. This study aims to determine weight loss in adolescents. The design of the study is a quasi-experimental design, with the One Group Pretest and Posttest designs. The population in this study was all eleventh-grade students in Muhammadiyah High School 01 Field of 63 students using total sampling techniques. The data used are primary data and secondary data. The data was analyzed using a t-test pair analysis test. Study results: The study results obtained a t-pair value of 6,740 and p-value=0.001, this proves p-value=0.001<α=0.05, then Ha was accepted and Ho was rejected, which means there was an influence of the Poker Application on adolescent knowledge about adolescent reproductive health. The behavioral signs of parents and minors can be well identified by parents. Keywords: Application “POKER” Knowledge Reproductive Health, Adolescents ABSTRAK Remaja merupakan kelompok rentan yang harus diberikan informasi tentang kesehatan reproduksi, remaja yang merupakan kelompok aktif penggunaan internet dapat dimanfaat untuk menggunakan aplikasi untuk mendapatkan informasu tentang kesehatan remaja, 34,5% remaja laki laki dan 33,3% remaja perempuan mulai berpacaran yang bersiko melakukan seks pranikah dan menularkan penyakit sesksual. Penelitian ini bertujuan untuk mengetahui pengaruh aplikasi pojok remaja terhadap pengetahuan remaja tentang kesehatan reproduksi pada remaja. Desain penelitian ini adalah quasi experimental designs, dengan rancangan One Group Pretest dan Posttest. Populasi dalam penelitian ini seluruh siswa kelas XI di SMA Muhammadiyah 01 Medan sebanyak 63 siswa dengan menggunakan teknik total populasi. Data yang digunakan adalah data primer dan sekunder. Data dianalisis dengan menggunakan uji analisis paired t-test. Hasil penelitian didapatkan nilai t-paired sebesar 6,740 dan p-value=0.001, hal ini membuktikan p-value=0.001< α=0.05, maka Ha diterima dan Ho ditolak, yang berarti ada pengaruh Aplikasi POKER terhadap pengetahuan remaja tentang kesehatan reproduksi remaja. Diharapkan Aplikasi POKER ini dapat dimanfaat dengan baik oleh remaja, keluarga serta dapat memberikan pemahaman yang baik sehingg siswa dapat memahaminya dengan benar Kata Kunci: Aplikasi “POKER” Pengetahuan Kesehatan Reproduksi, Remaja
Hubungan Kepemimpinan Transformasional Dosen terhadap Produktivitas Kerja Mahasiswa Keperawatan Universitas Malahayati Kota Bandar Lampung
Authors: Ryalita Novindri , Zainaro M. Arifki , Triyoso Triyoso 
Published: November 2024

ABSTRACT Transformational leadership of lecturers plays a crucial role in influencing the work productivity of students across various fields of study, including nursing. This leadership approach is essential in supporting the learning and development of nursing students. This study aims to explore and analyze the relationship between transformational leadership of lecturers and the work productivity of nursing students. By understanding the dynamics and influence of this leadership style, it is hoped to provide deep insights into the factors affecting the work productivity of nursing students. To know the relationship between transformasional leadership and work productivity of nursing students at Malahayati University, with a sample of 123 respondents. The sample approach used in this study is Simple Random sample. The analysis results indicate that the majority of lecturer’s exhibit non-transformasional leadership, and most nursing students are not productive. The p-value is 0.001 (<0.05), which means there is a significant relationship between the serving leadership of lecturers and the work productivity of students. It would be better for lecturers to be more nurturing, inspiring and motivating for students. Keywords: Transformasional Leadership, Work Productivity, Nursing Students ABSTRAK Kepemimpinan transformasional dosen memiliki peran penting dalam mempengaruhi produktivitas kerja mahasiswa di berbagai bidang studi, termasuk studi keperawatan. pendekatan kepemimpinan ini diperlukan dalam mendukung pembelajaran dan pengembangan mahasiswa keperawatan. Penelitian ini bertujuan untuk mengeksplorasi dan menganalisis hubungan antara kepemimpinan transformasional dosen dengan produktivitas kerja mahasiswa keperawatan. Dengan memahami dinamika dan pengaruh dari jenis kepemimpinan ini, diharapkan dapat memberikan wawasan yang mendalam mengenai faktor-faktor yang memengaruhi produktivitas kerja mahasiswa keperawatan. Diketahui hubungan gaya kepemimpinan transformasional terhadap produktivitas kerja mahasiswa keperawatan di universitas malahayati Kota Bandar Lampung. Jenis penelitian yang digunakan adalah kuantitatif dimana rancangan dalam penelitian ini menggunakan survey analitik dengan pendekatan cross-sectional. Populasi dalam penelitian ini adalah seluruh mahasiswa keperawatas universitas malahayati, dengan sampel berjumlah 123 responden. Teknik sampling dalam penelitian ini adalah Simple Random Sampling. Pada penelitian ini hasil analisis menunjukan sebagian besar kepemimpinan dosen tidak transformasional, dan Sebagian besar mahasiswa keperawatan tidak produktif, p-value 0,001 (<0,05) yang berarti ada hubungan antara kepemimpinan transformasional dosen terhadap produktivitas kerja mahasiswa. Sebaiknya untuk dosen lebih mengayomi, mengispirasi serta memotivasi mahasiswa. Kata Kunci: Kepemimpinan Transformasional, Produktivtas Kerja, Mahasiswa Keperawatan
Pengaruh Bubur Kulit Pisang Terhadap Sifat Mikrobiologis Dan Kimia Nira Gewang Serta Fisik Dan Organoleptik Gula Cair
Authors: Lalel Herianus J. D. , Rubak Yuliana Tandi , Nalle Ryan P.I. , Saingo Silvia Marise 
Published: November 2024

Nira gewang (Corypha utan Lamk) merupakan salah satu bahan baku gula cair di Pulau Timor. Nira mudah terfermentasin oleh mikroba camaran sehingga menurun mutunya. Untuk itu diperlukan bahan pengawet yang aman. Penelitian ini dilaksanakan menggunakan rancangan acak lengkap (RAL) dengan 4 perlakuan yaitu: kontrol (A0); 5% ekstrak kulit pisang kepok (A1); 10% ekstrak kulit pisang kepok (A2); 15% ekstrak kulit pisang kepok (A3) yang diulang sebanyak 3 kali. Bahan pengawet yang digunakan adalah kulit pisang kepok sedangkan parameter yang diamati adalah sifat mikrobiologis: total mikroba, dan sifat kimia: keasaman (pH) dan total padatan terlarut (TPT) nira serta sifat fisik: aktivitas air (Aw) dan sifat organoleptik gula cair. Hasil penelitian menunjukkan bahwa perlakuan penambahan ekstrak kulit pisang kepok pada nira gewang mampu mempengaruhi sifat mikrobiologis dan kimia nira gewang serta sifat fisik dan organoleptik gula cair. Perlakuan terbaik ditunjukkan oleh A3 (15% ekstrak kulit pisang kepok) yang ditinjau dari segi sifat kimia dan mikrobiologis nira, maupun sifat fisik gula cair. Sedangkan organoleptik terbaik dari gula cair ditemukan pada perlakuan 5% bubur kulit pisang.
Prostruc: an open-source tool for 3D structure prediction using homology modeling
Authors: Pawar Shivani V. , Banini Wilson Sena Kwaku , Shamsuddeen Musa Muhammad , Jumah Toheeb A. , Dolling Nigel N. O. , Tiamiyu Abdulwasiu , Awe Olaitan I. 
Published: November 2024

IntroductionHomology modeling is a widely used computational technique for predicting the three-dimensional (3D) structures of proteins based on known templates,evolutionary relationships to provide structural insights critical for understanding protein function, interactions, and potential therapeutic targets. However, existing tools often require significant expertise and computational resources, presenting a barrier for many researchers.MethodsProstruc is a Python-based homology modeling tool designed to simplify protein structure prediction through an intuitive, automated pipeline. Integrating Biopython for sequence alignment, BLAST for template identification, and ProMod3 for structure generation, Prostruc streamlines complex workflows into a user-friendly interface. The tool enables researchers to input protein sequences, identify homologous templates from databases such as the Protein Data Bank (PDB), and generate high-quality 3D structures with minimal computational expertise. Prostruc implements a two-stage vSquarealidation process: first, it uses TM-align for structural comparison, assessing Root Mean Deviations (RMSD) and TM scores against reference models. Second, it evaluates model quality via QMEANDisCo to ensure high accuracy.ResultsThe top five models are selected based on these metrics and provided to the user. Prostruc stands out by offering scalability, flexibility, and ease of use. It is accessible via a cloud-based web interface or as a Python package for local use, ensuring adaptability across research environments. Benchmarking against existing tools like SWISS-MODEL,I-TASSER and Phyre2 demonstrates Prostruc's competitive performance in terms of structural accuracy and job runtime, while its open-source nature encourages community-driven innovation.DiscussionProstruc is positioned as a significant advancement in homology modeling, making high-quality protein structure prediction more accessible to the scientific community.
CISepsis: a causal inference framework for early sepsis detection
Authors: Li Qiang , Li Dongchen , Jiao He , Wu Zhenhua , Nie Weizhi 
Published: November 2024

IntroductionThe early prediction of sepsis based on machine learning or deep learning has achieved good results.Most of the methods use structured data stored in electronic medical records, but the pathological characteristics of sepsis involve complex interactions between multiple physiological systems and signaling pathways, resulting in mixed structured data. Some researchers will introduce unstructured data when also introduce confounders. These confounders mask the direct causality of sepsis, leading the model to learn misleading correlations. Finally, it affects the generalization ability, robustness, and interpretability of the model.MethodsTo address this challenge, we propose an early sepsis prediction approach based on causal inference which can remove confounding effects and capture causal relationships. First, we analyze the relationship between each type of observation, confounder, and label to create a causal structure diagram. To eliminate the effects of different confounders separately, the methods of back-door adjustment and instrumental variable are used. Specifically, we learn the confounder and an instrumental variable based on mutual information from various observed data and eliminate the influence of the confounder by optimizing mutual information. We use back-door adjustment to eliminate the influence of confounders in clinical notes and static indicators on the true causal effect.ResultsOur method, named CISepsis, was validated on the MIMIC-IV dataset. Compared to existing state-of-the-art early sepsis prediction models such as XGBoost, LSTM, and MGP-AttTCN, our method demonstrated a significant improvement in AUC. Specifically, our model achieved AUC values of 0.921, 0.920, 0.919, 0.923, 0.924, 0.926, and 0.926 at the 6, 5, 4, 3, 2, 1, and 0 time points, respectively. Furthermore, the effectiveness of our method was confirmed through ablation experiments.DiscussionOur method, based on causal inference, effectively removes the influence of confounding factors, significantly improving the predictive accuracy of the model. Compared to traditional methods, this adjustment allows for a more accurate capture of the true causal effects of sepsis, thereby enhancing the model's generalizability, robustness, and interpretability. Future research will explore the impact of specific indicators or treatment interventions on sepsis using counterfactual adjustments in causal inference, as well as investigate the potential clinical application of our method.
Case Report: Anomalous origin of the right coronary artery leading to cardiac arrest induced by sexual activity: a previously unreported pathogenetic condition
Authors: Tang Junchu , Li Da , Wang Shuizhu 
Published: November 2024

BackgroundThe Anomalous Origin of the Right Coronary Artery from the Left Coronary Sinus (ARCA-LCS) is a rare congenital cardiac condition where the right coronary artery emerges from the left sinus instead of the right coronary sinus of Valsalva. The clinical significance of ARCA-LCS lies in its potential to cause myocardial ischemia or sudden cardiac death, particularly under physical exertion. In this case, a patient experienced sudden cardiac arrest during sexual activity, which has not previously been reported.Case presentationSix years ago, a 37-year-old man was admitted with sudden cardiac arrest during sexual intercourse. No previous history of hypertension or diabetes. There was no abnormality in physical examination. Transthoracic echocardiogram, bilateral carotid Doppler ultrasound, and electrocardiogram were normal. Cranial magnetic resonance imaging and magnetic resonance angiography showed no abnormalities. A treadmill exercise test revealed ischemic changes. Coronary computed tomography angiography showed ARCA-LCS, and passage through the vessel wall between the aorta and pulmonary artery.ConclusionThis case illustrates a patient with asymptomatic ARCA-LCS for 37 years who did not receive appropriate treatment during a previous visit, but who subsequently experienced a serious cardiovascular event that demonstrated the potential harm of the disease. Therefore, timely intervention in patients with ARCA-LCS, especially in high-risk groups, is critical to prevent potentially catastrophic cardiovascular events. However, in the present case report, the patient did not experience a similar event during the 6-year follow-up by avoiding overexertion and changing his lifestyle at the time of previous onset of the disease. Further studies are needed to optimize diagnostic and therapeutic strategies for ARCA-LCS.
Non-linear relationship between platelet count and 28-day mortality in critically ill patients with infective endocarditis: a retrospective cohort study from MIMIC IV database
Authors: Huang Yingxiu , Ao Ting , Zhen Peng , Hu Ming 
Published: November 2024

BackgroundThe relationship between platelet count and 28-day mortality in critically ill patients with infective endocarditis (IE) is currently not well established.ObjectiveThis study aims to investigate the impact of platelet count on 28-day mortality in critically ill patients with infective endocarditis.MethodsA retrospective cohort study was conducted involving 450 participants diagnosed with infective endocarditis and admitted to intensive care units (ICU). Vital signs, laboratory parameters and comorbidity were collected for all participants to analyze the association between platelet count and 28-day mortality. In order to assess the independent association between platelet count and 28-day mortality, we employed multivariable cox hazard regression analyses and smooth curve fitting. A further analysis was conducted using a two-piecewise linear regression model to examine the nonlinear association between platelet count and in-hospital mortality.ResultsA total of 450 critically ill patients with infective endocarditis were included in the study. The mean age was 57.4 years, and 64.2% were male. The overall 28-day mortality rate was 20%. A non-linear relationship was observed between platelet count and 28-day mortality. Two different slopes were identified, with correlations between platelet count and 28-day mortality in patients with IE differing significantly below and above the inflection point, which was approximately 141 K/µl. On the left side of the inflection point, the hazard ratio was 0.990 (hazard ratio: 0.990, 95% confidence interval: 0.982–0.997, p = 0.006). However, on the right side of the inflection point, the hazard ratio increased marginally to 1.0004 (HR: 1.0004, 95% CI: 0.997–1.004, p = 0.825). Notably, the association lacked statistical significance on the right side of the inflection point.ConclusionA nonlinear association between platelet count and 28-day mortality was observed in critically ill patients with infective endocarditis. The optimal platelet count associated with the lowest risk of 28-day mortality was above 141 k/µl.
Teaching basic computer programming to young adults with intellectual disability
Authors: Stimoli Maria Agatina , Di Blasi Francesco Domenico , Maccarrone Silvestro , Costanzo Angela Antonia , Occhipinti Paola , Buono Serafino 
Published: November 2024

IntroductionTeaching computer programming can be challenging, especially for individuals with intellectual disability (ID) who exhibit a wide range of learning abilities and behavioral characteristics. This study aimed to investigate the effectiveness of an intervention designed to teach computer programming skills to individuals with ID.MethodFour women with ID, aged 27 to 54 years, were selected to participate in the study. Participants were taught computer programming using authoring software to create multimedia educational activities. A discrete trial teaching (DTT) approach was employed to teach specific skills and to gradually fade prompts to promote independent learning. A multiple-probe design across subjects was used to evaluate the effectiveness of the intervention. This design involved a baseline phase, a training phase with a most-to-least prompting procedure, and a 1-month follow-up phase to assess skill maintenance.ResultsThe results demonstrated that all participants were able to acquire the necessary programming skills and complete the assigned tasks independently.ConclusionComputer programming can provide valuable learning and development opportunities for individuals with ID. However, it is essential to tailor the instruction to individual needs and provide appropriate support.
Exploring the relationship between air pollution, non-alcoholic fatty liver disease, and liver function indicators: a two-sample Mendelian randomization analysis study
Authors: Song Qingliang , Pan Jinyue , Pan Maoxing , Zheng Chuiyang , Fan Wen , Zhen Jianwei , Pi Dajin , Liang Zheng , Shen Haiyan , Li Yuanyou , Yang Qinhe , Zhang Yupei 
Published: November 2024

Background and aimsNon-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder worldwide, with an increasing incidence in recent years. While previous studies have suggested an association between the air pollutant PM2.5 and NAFLD, there is still considerable debate regarding the existence of a clear causal relationship between air pollution and NAFLD. This study aims to employ Mendelian randomization methods to evaluate the causal relationship between major air pollutants and NAFLD.MethodWe conducted Mendelian randomization analyses on a large-scale publicly available genome-wide association study (GWAS) dataset of European populations to dissect the association between air pollutants, NAFLD, and liver function indicators. We used five different analysis methods, including Inverse-variance weighted (IVW), Weighted median, MR-Egger, Simple mode, and Weighted mode, to analyze the data. We also tested for pleiotropy, heterogeneity, and sensitivity of the results.ResultsThis study utilized four common exposures related to air pollution and four outcomes related to NAFLD. The results regarding the association between air pollutants and NAFLD (PM2.5: P=0.808, 95% CI=0.37-3.56; PM10: P=0.238, 95% CI=0.33-1.31; nitrogen dioxide: P=0.629, 95% CI=0.40-4.61; nitrogen oxides: P=0.123, 95% CI=0.13-1.28) indicated no statistically significant correlation between them. However, notably, there was a causal relationship between PM10 and serum albumin (ALB) levels (P=0.019, 95% CI=1.02-1.27).ConclusionThis MR study found no evidence of a causal relationship between air pollution and NAFLD in European populations. However, a statistically significant association was observed between PM10 and ALB levels, suggesting that the air pollutant PM10 may impact the liver’s ability to synthesize proteins.