bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radioguided surgery with β radiation: a novel application with Ga68
Authors: Collamati Francesco , Bocci Valerio , Castellucci Paolo , De Simoni Micol , Fanti Stefano , Faccini Riccardo , Giordano Alessandro , Maccora Daria , Mancini-Terracciano Carlo , Marafini Michela , Mirabelli Riccardo , Morganti Silvio , Schiavina Riccardo , Scotognella Teresa , Traini Giacomo , Solfaroli Camillocci Elena 
Published: October 2018

AbstractRadio Guided Surgery is a technique helping the surgeon in the resection of tumors: a radiolabeled tracer is administered to the patient before surgery and then the surgeon evaluates the completeness of the resection with a handheld detector sensitive to emitted radiation. Established methods rely on γ emitting tracers coupled with γ detecting probes. The efficacy of this technique is however hindered by the high penetration of γ radiation, limiting its applicability to low background conditions. To overtake such limitations, a novel approach to RGS has been proposed, relying on β− emitting isotopes together with a dedicated β probe. This technique has been proved to be effective in first ex-vivo trials. We discuss in this paper the possibility to extend its application cases to 68Ga, a β+ emitting isotope widely used today in nuclear medicine. To this aim, a retrospective study on 45 prostatic cancer patients was performed, analysing their 68Ga-PSMA PET images to asses if the molecule uptake is enough to apply this technique. Despite the expected variability both in terms of SUV (median 4.1, IQR 3.0–6.1) and TNR (median 9.4, IQR 5.2–14.6), the majority of cases have been found to be compatible with β-RGS with reasonable injected activity and probing time (5 s).
Evaluation of Hepatic Toxicity after Repeated Stereotactic Body Radiation Therapy for Recurrent Hepatocellular Carcinoma using Deformable Image Registration
Authors: Lee Sumin , Kim Hojin , Ji Yunseo , Cho Byungchul , Kim Su Ssan , Jung Jinhong , Kwak Jungwon , Park Jin-hong , Lee Sang-wook , Kim Jong Hoon , Yoon Sang Min 
Published: October 2018

AbstractThis study aimed to evaluate hepatic toxicity after repeated stereotactic body radiation therapy (SBRT) for recurrent hepatocellular carcinoma (HCC) using deformable image registration (DIR). Between January 2007 and December 2015, 85 patients who underwent two sessions of SBRT for HCC treatment were retrospectively analyzed. A DIR technique was used to calculate the cumulative dose of the first and second SBRT to the normal liver by matching two computed tomography simulation images. The Dice similarity coefficient (DSC) index was calculated to evaluate DIR accuracy. Before the first and second SBRT, 6 (7.1%) and 12 (14.1%) patients were Child-Pugh class B, respectively. Median tumor size was 1.7 cm before both SBRT treatments. Mean DSC index value was 0.93, being >0.9 in 79 (92.9%) registrations. Median cumulative mean liver dose (MLD) was 9.3 Gy (interquartile range, 7.6–11.7). Radiation-induced liver disease developed in three patients, and two of them, with Child-Pugh class B, experienced irreversible liver function deterioration following the second SBRT. The DIR method provided reliable information regarding cumulative doses to the liver. In patients with Child-Pugh class A liver function, repeated SBRT for small recurrent HCC could be safely performed with acceptable hepatic toxicity.
Dipolar couplings in solid polypeptides probed by 14N NMR spectroscopy
Authors: Carnevale Diego , Grosjean Benoit , Bodenhausen Geoffrey 
Published: October 2018

AbstractThe acquisition of 14N NMR spectra in solid samples is challenging due to quadrupolar couplings with magnitudes up to several MHz. This nucleus is nonetheless important as it is involved in the formation of essential secondary structures in biological systems. Here we report the structural study of the atomic environment of amide functions in polypeptides using magic-angle spinning NMR spectroscopy of the ubiquitous 14N isotope. The cyclic undecapeptide cyclosporin, in which only four hydrogen atoms are directly bound to nitrogen atoms, is chosen for illustration. Structural details of different environments can be revealed without resorting to isotopic enrichment. The network of inter- and intra-residue dipolar couplings between amide 14N nuclei and nearby protons can be probed and mapped out up to a tunable cutoff distance. Density functional theory calculations of NMR quadrupolar interaction tensors agree well with the experimental evidence and allow the unambiguous assignment of all four non-methylated NH nitrogen sites and neighboring proton nuclei.
A state variable for crumpled thin sheets
Authors: Gottesman Omer , Andrejevic Jovana , Rycroft Chris H. , Rubinstein Shmuel M. 
Published: October 2018

AbstractDespite the apparent ease with which sheets of paper are crumpled and tossed away, crumpling dynamics are often considered a paradigm of complexity. This arises from the infinite number of configurations that disordered, crumpled sheets can take. Here we experimentally show that key aspects of axially confined crumpled Mylar sheets have a very simple description; evolution of damage in crumpling dynamics can largely be described by a single global quantity—the total length of creases. We follow the evolution of the damage network in repetitively crumpled elastoplastic sheets, and show that the dynamics are deterministic, depending only on the instantaneous state of the crease network and not on the crumpling history. We also show that this global quantity captures the crumpling dynamics of a sheet crumpled for the first time. This leads to a remarkable reduction in complexity, allowing a description of a highly disordered system by a single state parameter.
Perceptual Organization of Interrupted Speech and Text
Authors: Shafiro Valeriy , Fogerty Daniel , Smith Kimberly , Sheft Stanley 
Published: October 2018

Purpose
Visual recognition of interrupted text may predict speech intelligibility under adverse listening conditions. This study investigated the nature of the linguistic information and perceptual processes underlying this relationship.

Method
To directly compare the perceptual organization of interrupted speech and text, we examined the recognition of spoken and printed sentences interrupted at different rates in 14 adults with normal hearing. The interruption method approximated deletion and retention of rate-specific linguistic information (0.5–64 Hz) in speech by substituting either white space or silent intervals for text or speech in the original sentences.

Results
A similar U-shaped pattern of cross-rate variation in performance was observed in both modalities, with minima at 2 Hz. However, at the highest and lowest interruption rates, recognition accuracy was greater for text than speech, whereas the reverse was observed at middle rates. An analysis of word duration and the frequency of word sampling across interruption rates suggested that the location of the function minima was influenced by perceptual reconstruction of whole words. Overall, the findings indicate a high degree of similarity in the perceptual organization of interrupted speech and text.

Conclusion
The observed rate-specific variation in the perception of speech and text may potentially affect the degree to which recognition accuracy in one modality is predictive of the other.
Research on the RBF‐PID control method for the motor actuator used in a UHV GIS disconnector
Authors: Kejian Shi , Bin Li , Feiming Wang , Bin Zhang , Wei Luo , Jiale Deng 
Published: October 2018

To improve the reliability and intelligent level of the AC transmission system, the radial basis function‐based proportional‐integral‐derivative (RBF‐PID) control method for the motor actuator used in the 550 kV gas‐insulated switchgear (GIS) disconnector is proposed. According to the dynamic mathematical model of the motor actuator, the main structure of the RBF neural network based on the gradient descent method for learning algorithm is constructed. An identification function is formed by taking values of the output error square, and then by gathering information on the real‐time tuning parameters of PID. Based on that, the simulation of the control system is constructed. The comparative analyses of the tracking control characteristics and the servo following error of the disconnector's contact speed between double‐loop PID and RBF‐PID are done through the computational and experiment methods, respectively. The results show that 550 kV GIS disconnector with the motor actuator by the RFB‐PID control method has better controllability, and the servo following error is controlled within 0.1 m/s.
Calculation and protection on the lighting intruding waves of 550 kv GIS substation
Authors: Sui Dongpeng , Huang Fucun , Chi Danyi , Wang Yanan , Kang Jiyang , Zhao Dan 
Published: October 2018

Electromagnetic Transient Programme has been used to calculate the lightning intruding wave of 550 kV GIS substation. The effects of mode operation, surge impedance and length of cable have been considered in the process of calculation. Besides, the corresponding protection scheme has been proposed on the basis of the results of calculation. Results of the research show that when the system is operating in single‐in‐single‐out way, the voltage intruded into the substation is highest; the bigger of surge impedance for GIS, the higher of the voltage; the overvoltage amplitude decreases with the increase of the length of the cable; the installation of metal oxide arrester (MOA) at the entrance of GIS and the region close to the transformer or using the reactor instead the arrestor at the entrance of GIS can limit the voltage strike on the transformer effectively.
Deciphering the atmosphere of HAT-P-12b: solving discrepant results
Authors: Alexoudi X. , Mallonn M. , von Essen C. , Turner J. D. , Keles E. , Southworth J. , Mancini L. , Ciceri S. , Granzer T. , Denker C. , Dineva E. , Strassmeier K. G. 
Published: October 2018

Context. Two independent investigations of the atmosphere of the hot Jupiter HAT-P-12b by two different groups resulted in discrepant solutions. Using broad-band photometry from the ground, one study found a flat and featureless transmission spectrum that was interpreted as gray absorption by dense cloud coverage. The second study made use of Hubble Space Telescope (HST) observations and found Rayleigh scattering at optical wavelengths caused by haze.
Aims. The main purpose of this work is to determine the source of this inconsistency and provide feedback to prevent similar discrepancies in future analyses of other exoplanetary atmospheres.
Methods. We studied the observed discrepancy via two methods. With further broad-band observations in the optical wavelength regions, we strengthened the previous measurements in precision, and with a homogeneous reanalysis of the published data, we were able to assess the systematic errors and the independent analyses of the two different groups.
Results. Repeating the analysis steps of both works, we found that deviating values for the orbital parameters are the reason for the aforementioned discrepancy. Our work showed a degeneracy of the planetary spectral slope with these parameters. In a homogeneous reanalysis of all data, the two literature data sets and the new observations converge to a consistent transmission spectrum, showing a low-amplitude spectral slope and a tentative detection of potassium absorption.
Supercluster A2142 and collapse in action: infalling and merging groups and galaxy transformations
Authors: Einasto Maret , Gramann Mirt , Park Changbom , Kim Juhan , Deshev Boris , Tempel Elmo , Heinämäki Pekka , Lietzen Heidi , Lähteenmäki Anne , Einasto Jaan , Saar Enn 
Published: October 2018

Context. Superclusters with collapsing cores represent dynamically evolving environments for galaxies, galaxy groups, and clusters.Aims. We study the dynamical state and properties of galaxies and groups in the supercluster SCl A2142 that has a collapsing core, to understand its possible formation and evolution.Methods. We find the substructure of galaxy groups using normal mixture modelling. We have used the projected phase space (PPS) diagram, spherical collapse model, clustercentric distances, and magnitude gap between the brightest galaxies in groups to study the dynamical state of groups and to analyse group and galaxy properties. We compared the alignments of groups and their brightest galaxies with the supercluster axis.Results. The supercluster core has a radius of about 8h−1Mpc and total massMtot≈ 2.3 × 1015h−1M⊙and is collapsing. Galaxies in groups on the supercluster axis have older stellar populations than off-axis groups, with median stellar ages 4 − 6 and < 4 Gyr, correspondingly. The cluster A2142 and the group Gr8 both host galaxies with the oldest stellar populations among groups in SCl A2142 having the median stellar aget> 8 Gyr. Recently quenched galaxies and active galactic nuclei (AGNs) are mostly located at virial radii or in merging regions of groups, and at clustercentric distancesDc≈ 6h−1Mpc. The most elongated groups lie along the supercluster axis and are aligned with it. Magnitude gaps between the brightest galaxies of groups are less than one magnitude, suggesting that groups in SCl A2142 are dynamically young.Conclusions. The collapsing core of the supercluster, infall of galaxies and groups, and possible merging groups, which affect galaxy properties and may trigger the activity of AGNs, show how the whole supercluster is evolving.
Knoblauch zur Gesunderhaltung
Authors: Vlachojannis Julia , Chrubasik-Hausmann Sigrun 
Published: October 2018

ZusammenfassungEs gibt viele klinische Studien, deren Daten in zusammenführenden Studien gepoolt wurden. Sie belegen, dass Knoblauch ein natürlicher Blutdruck- und Cholesterinsenker ist. Ein normaler Blutdruck wurde durch Knoblauch nicht beeinflusst. Unklar ist, warum manche Hypertoniker und manche Patienten mit hohen Blutfetten nicht auf Knoblauch ansprechen. Viele Studien weisen auf eine Senkung der kardiovaskulären Risikofaktoren und auf eine Senkung des Risikos für Herz-Kreislauf-Komplikationen (Schlaganfall, Herzinfarkt) hin sowie auf die Reduktion arteriosklerotischer Gefäßveränderungen. Bei Erkältungskrankheiten ist die Wirksamkeit von Knoblauch vielversprechend, bei Krebsleiden, Rheuma, Diabetes und bei der Alzheimer-Demenz dagegen noch nicht endgültig geklärt.Knoblauch und Zubereitungen daraus können mit unerwünschten Ereignissen (UEs) einhergehen wie Ausdünstung, Sodbrennen, Übelkeit, Erbrechen und Durchfall. Bei der Einnahme geruchloser Knoblauchpräparate sind UEs nicht zu befürchten. Auf Wechselwirkungen von weißem Knoblauch mit Medikamenten muss geachtet werden (wohl kaum bei Einnahme geruchloser Knoblauchpräparate). Vorsichtshalber sollten aber auch die Knoblauchextrakte mit wasserlöslichen Inhaltsstoffen nicht zusammen mit synthetischen Gerinnungshemmern eingenommen bzw. vor Operationen abgesetzt werden. Obwohl Knoblauch in den empfohlenen Dosen nicht toxisch wirkt, sollten Schwangere Knoblauch nur in Maßen zu sich nehmen, bis das komplette Sicherheitsprofil erstellt ist.
Cochlear Implantation for Children and Adults with Severe-to-Profound Hearing Loss
Authors: Warren Sarah , Messersmith Jessica , Entwisle Lavin 
Published: October 2018

AbstractCochlear implants (CIs) have proven to be a useful treatment option for individuals with severe-to-profound hearing loss by providing improved access to one's surrounding auditory environment. CIs differ from traditional acoustic amplification by providing information to the auditory system via electrical stimulation. Both postlingually deafened adults and prelingually deafened children can benefit from a CI; however, outcomes with a CI can vary. Numerous factors can impact performance outcomes with a CI. It is important for the audiologist to understand what factors might play a role and impact performance outcomes with a CI so that they can effectively counsel the recipient and their family, as well as establish appropriate and realistic expectations with a CI. This review article will discuss the CI candidacy process, CI programming and postoperative follow-up care, as well as considerations across the lifespan that may affect performance outcomes with a CI.
First Report of Congenital Short Bowel Syndrome in an Iranian Patient Caused by a Mutation in the CLMP Gene
Authors: Gharesouran Jalal , Esfahani Behnaz , Valilou Saeed , Moradi Mohsen , Mousavi Mir , Rezazadeh Maryam 
Published: October 2018

AbstractCongenital short bowel syndrome (CSBS) is a rare congenital neonatal disorder. CSBS results from intestinal impairment during embryogenesis. Mutated CXADR-like membrane protein (CLMP) and Filamin A genes are involved in the cause of CSBS. In this study, due to our misdiagnosis, we had to perform whole exome sequencing on the patient, and also we implemented cosegregation analysis on his parents with consanguineous marriage and also parents' mothers. We identified a homozygous loss of function mutation in the CLMP gene in exon 5 (c.664C > T, p.R222X). Also, both parents and grandmothers of the proband were heterozygous for this mutation. Loss of function mutation in CLMP causes CSBS, leading to impaired intestinal development.
Acute Gaucher Disease-Like Condition in an Indian Infant with a Novel Biallelic Mutation in the Prosaposin Gene
Authors: Radha Rama Devi Akella , Kadali Srilatha , Radhika Ananthaneni , Singh Vineeta , Kumar M. , Reddy Gummadi , Naushad Shaik 
Published: October 2018

AbstractThis is the first reported case of prosaposin (PSAP) mutation from India manifesting as an acute neuronal Gaucher disease-like condition. A 2-month-old male baby presented with encephalopathy, resistant tonic–clonic seizures, moderate hepatosplenomegaly, hypotonia, and cherry red spot in the retinae. The child had anemia, thrombocytopenia, elevated chitotriosidase, and normal activity of acid sphingomyelinase and low normal activity of β-glucosidase 1 (β-glucocerebrosidase 1, GBA). The child succumbed in the fourth month of life due to persistent respiratory distress and refractory seizures. The clinical phenotype, cherry red spots, elevated chitotriosidase, and lysosomal assays led to the suspicion of Gaucher disease. Exome sequencing revealed a homozygous stop codon mutation in the PSAP gene (c.G1228T, p.Glu410ter). Prenatal diagnosis in the next pregnancy revealed a carrier fetus, who was unaffected postnatally. The diagnosis of specific activator deficiency such as saposin C and saposin D deficiency (in the current study) should be considered and tested for when Gaucher disease is suspected in an infant with partially deficient or near normal GBA activity.
Short‐term slackline training improves task‐specific but not general balance in female handball players
Authors: Ringhof Steffen , Zeeb Nina , Altmann Stefan , Neumann Rainer , Woll Alexander , Stein Thorsten 
Published: October 2018

AbstractSlackline training has been shown to improve balance and neuromuscular performance. However, recent studies suggested that balance is task‐specific, implying that transferability of balance skills is limited and might depend on the similarity of the tasks. This study therefore investigated if short‐term slackline training could improve performance in balance tasks that are either more or less similar to the trained slackline task. Furthermore, we assessed potential transfer effects to other neuromuscular performance tests.25 female handball players (23.7 ± 3.9 years) participated in our study and were matched to either a slackline training (SLT; n = 14) or a control group (CON; n = 11). The intervention comprised 12 sessions with overall 120 minutes of slackline training using single and double slacklines. Slackline standing time and measures of dynamic and static balance were assessed before and after the intervention, as well as power and sprint‐related performance parameters.Two‐way repeated‐measures ANOVA found a significant group × time interaction for slackline standing time, indicating larger training effects for SLT. For the remaining dynamic and static balance tests, no significant interactions were found. With regard to neuromuscular performance, there was a significant group × time interaction only in change of direction.In essence, the study showed that slackline training induced task‐specific balance improvements without affecting general balance. This adds further evidence to the task‐specificity principle of balance, although the specificity of the sample as well as the briefness of the intervention should be taken into account when generalizing our findings. Nonetheless, this study contains practical implications for team sports interventions and future balance training studies, highlighting the importance of selecting appropriate balance exercises to yield rapid and the desired training outcomes.
Joint and plantar loading in table tennis topspin forehand with different footwork
Authors: Lam Wing‐Kai , Fan Jia‐Xing , Zheng Yi , Lee Winson Chiu‐Chun 
Published: October 2018

AbstractTable tennis players often execute one‐step, side‐step or cross‐step to move to an appropriate position for topspin forehand. However, to our knowledge, no studies have investigated the footwork effects on lower‐limb kinetics and kinematics, which are related to playing performance and injury prevention. This study examined the ground reaction forces, joint kinetics and in‐shoe plantar pressure distribution during topspin forehand with three typical footwork patterns. Fifteen male table tennis players performed cross‐court topspin forehands in one‐step, side‐step and cross‐step. Force plate, motion capturing, and instrumented insole systems were used to measure ground reaction force, joint moments and plantar pressure variables. One‐way ANONA with repeated measures was performed to determine any significant differences between footwork. Results indicated that participants exhibited significantly higher ground reaction force loadings, knee flexion angle, knee moment, ankle inversion and moment during side‐step and cross‐step compared with one‐step footwork condition (p < .01). Plantar pressure data indicated that the significantly higher peak pressure were observed in the total foot, toe, 1st, 2nd and 5th metatarsal regions during side‐step and cross‐step (p < .01). Additionally, cross‐step had induced higher peak pressure in medial midfoot and heel regions than one‐step and higher peak pressure in total and 1st metatarsal regions than side‐step (p < .01). These results suggest that foot orthotic designs should consider the stronger emphasis on those high‐pressured areas and that the differential joint and plantar loadings in side‐step and cross‐step may provide useful insights to injury mechanism and training protocol development.