bluuebunny/crossref_metadata_2025_split huggingface dataset:
Head-to-head comparison of two engineered cardiac grafts for myocardial repair: From scaffold characterization to pre-clinical testing
Authors: Perea-Gil Isaac , Gálvez-Montón Carolina , Prat-Vidal Cristina , Jorba Ignasi , Segú-Vergés Cristina , Roura Santiago , Soler-Botija Carolina , Iborra-Egea Oriol , Revuelta-López Elena , Fernández Marco A. , Farré Ramon , Navajas Daniel , Bayes-Genis Antoni 
Published: April 2018

AbstractCardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. We developed two engineered cardiac grafts, based on decellularized scaffolds from myocardial and pericardial tissues and repopulated them with adipose tissue mesenchymal stem cells (ATMSCs). The structure, macromechanical and micromechanical scaffold properties were preserved upon the decellularization and recellularization processes, except for recellularized myocardium micromechanics that was ∼2-fold stiffer than native tissue and decellularized scaffolds. Proteome characterization of the two acellular matrices showed enrichment of matrisome proteins and major cardiac extracellular matrix components, considerably higher for the recellularized pericardium. Moreover, the pericardial scaffold demonstrated better cell penetrance and retention, as well as a bigger pore size. Both engineered cardiac grafts were further evaluated in pre-clinical MI swine models. Forty days after graft implantation, swine treated with the engineered cardiac grafts showed significant ventricular function recovery. Irrespective of the scaffold origin or cell recolonization, all scaffolds integrated with the underlying myocardium and showed signs of neovascularization and nerve sprouting. Collectively, engineered cardiac grafts -with pericardial or myocardial scaffolds- were effective in restoring cardiac function post-MI, and pericardial scaffolds showed better structural integrity and recolonization capability.
Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico
Authors: Saavedra-Rodriguez Karla , Maloof Farah Vera , Campbell Corey L. , Garcia-Rejon Julian , Lenhart Audrey , Penilla Patricia , Rodriguez Americo , Sandoval Arturo Acero , Flores Adriana E. , Ponce Gustavo , Lozano Saul , Black William C. 
Published: April 2018

AbstractAedes aegyptiis the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and effective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larval and adult populations. Insecticidal control ofAe. aegyptiis challenging, due to a recent rapid global increase in knockdown-resistance (kdr) to pyrethroid insecticides. Widespread, heavy use of pyrethroid space-sprays has created an immense selection pressure for kdr, which is primarily under the control of the voltage-gated sodium channel gene (vgsc). To date, eleven replacements invgschave been discovered, published and shown to be associated with pyrethroid resistance to varying degrees. In Mexico, F1,534C and V1,016I have co-evolved in the last 16 years acrossAe. aegyptipopulations. Recently, a novel replacement V410L was identified in Brazil and its effect onvgscwas confirmed by electrophysiology. Herein, we screened V410L in 25Ae. aegyptihistorical collections from Mexico, the first heterozygote appeared in 2002 and frequencies have increased in the last 16 years alongside V1,016I and F1,534C. Knowledge of the specificvgscreplacements and their interaction to confer resistance is essential to predict and to develop strategies for resistance management.
Genome-wide Identification and characterization of circular RNAs in the rice blast fungus Magnaporthe oryzae
Authors: Yuan Jialan , Wang Zhao , Xing Junjie , Yang Qingyong , Chen Xiao-Lin 
Published: April 2018

AbstractNumerous circRNAs have been identified in different organisms, but little attention has been addressed on fungal circRNAs. Here, we identified a total of 8,848 circRNAs from the model plant pathogenic fungusM. oryzae. 5,840 circRNAs were identified from mycelium, 2,721 circRNAs from conidium, while only 287 circRNAs from both tissues. This indicated that most of theM. oryzaecircRNAs were specifically expressed in mycelium or in conidium. Parental genes of circRNAs in mycelium were enriched in basic metabolisms required for normal growth, while in conidium, they were enriched in biogenesis of storages potentially used for infection.M. oryzaecircRNAs could also bind to miRNAs, suggesting they may also function as sponges in fungi. This study suggestedM. oryzaecircRNAs could play important roles in regulation of growth and development.
What calls for service tell us about suicide: A 7-year spatio-temporal analysis of neighborhood correlates of suicide-related calls
Authors: Marco Miriam , Gracia Enrique , López-Quílez Antonio , Lila Marisol 
Published: April 2018

AbstractPrevious research has shown that neighborhood-level variables such as social deprivation, social fragmentation or rurality are related to suicide risk, but most of these studies have been conducted in the U.S. or northern European countries. The aim of this study was to analyze the spatio-temporal distribution of suicide in a southern European city (Valencia, Spain), and determine whether this distribution was related to a set of neighborhood-level characteristics. We used suicide-related calls for service as an indicator of suicide cases (n = 6,537), and analyzed the relationship of the outcome variable with several neighborhood-level variables: economic status, education level, population density, residential instability, one-person households, immigrant concentration, and population aging. A Bayesian autoregressive model was used to study the spatio-temporal distribution at the census block group level for a 7-year period (2010–2016). Results showed that neighborhoods with lower levels of education and population density, and higher levels of residential instability, one-person households, and an aging population had higher levels of suicide-related calls for service. Immigrant concentration and economic status did not make a relevant contribution to the model. These results could help to develop better-targeted community-level suicide prevention strategies.
Water harvesting from air with a hygroscopic salt in a hydrogel–derived matrix
Authors: Kallenberger Paul A. , Fröba Michael 
Published: April 2018

AbstractThe extraction of water from air is a promising way to supply fresh water, especially in remote, arid regions. This process can be supported by desiccant materials such as zeolites, metal−organic frameworks, or hygroscopic salts. Here we present a composite material that is able to absorb 660 kg of water per cubic meter of bulk material from air at 10 mbar water vapor pressure and 28 °C. The material consists of calcium chloride incorporated into an alginate-derived matrix. A simple synthesis route leads to spherical beads of the composite with a diameter of approximately 2 mm. This macroscopic structure allows for good vapor permeability through packed beds. The collected water can be released at 100 °C, potentially enabling a solar-driven application. In addition, the synthetic route uses cheap, non-toxic, and easily accessible materials allowing for widespread application.
Gaia Data Release 2
Authors: Hambly N. C. , Cropper M. , Boudreault S. , Crowley C. , Kohley R. , de Bruijne J. H. J. , Dolding C. , Fabricius C. , Seabroke G. , Davidson M. , Rowell N. , Collins R. , Cross N. , Martín-Fleitas J. , Baker S. , Smith M. , Sartoretti P. , Marchal O. , Katz D. , De Angeli F. , Busso G. , Riello M. , Allende Prieto C. , Els S. , Corcione L. , Masana E. , Luri X. , Chassat F. , Fusero F. , Pasquier J. F. , Vétel C. , Sarri G. , Gare P. 
Published: April 2018

Context. The European Space Agency’s Gaia satellite was launched into orbit around L2 in December 2013. This ambitious mission has strict requirements on residual systematic errors resulting from instrumental corrections in order to meet a design goal of sub-10 microarcsecond astrometry. During the design and build phase of the science instruments, various critical calibrations were studied in detail to ensure that this goal could be met in orbit. In particular, it was determined that the video-chain offsets on the analogue side of the analogue-to-digital conversion electronics exhibited instabilities that could not be mitigated fully by modifications to the flight hardware.
Aims. We provide a detailed description of the behaviour of the electronic offset levels on short (<1 ms) timescales, identifying various systematic effects that are known collectively as “offset non-uniformities”. The effects manifest themselves as transient perturbations on the gross zero-point electronic offset level that is routinely monitored as part of the overall calibration process.
Methods. Using in-orbit special calibration sequences along with simple parametric models, we show how the effects can be calibrated, and how these calibrations are applied to the science data. While the calibration part of the process is relatively straightforward, the application of the calibrations during science data processing requires a detailed on-ground reconstruction of the readout timing of each charge-coupled device (CCD) sample on each device in order to predict correctly the highly time-dependent nature of the corrections.
Results. We demonstrate the effectiveness of our offset non-uniformity models in mitigating the effects in Gaia data.
Conclusions. We demonstrate for all CCDs and operating instrument/modes on board Gaia that the video-chain noise-limited performance is recovered in the vast majority of science samples.
Recent Developments in the Synthesis of Pyrido[1,2-a]benzimidazoles
Authors: Kapoor Kamal , Das Parthasarathi , Khajuria Rajni , Rasheed Sk. , Khajuria Chhavi 
Published: April 2018

Pyrido[1,2-a]benzimidazole is one of the most important azaheterocyclic compounds consisting of three fused aromatic rings. Molecules containing this core have displayed a wide range of applications in the field of medicinal chemistry. The synthesis of pyrido[1,2-a]benzimidazole and its derivatives has attracted organic chemists because of its tremendous utility in interdisciplinary branches of chemistry. In this context, this review discusses the main advances in the synthesis of pyrido[1,2-a]benzimidazoles via metal-mediated and metal-free reactions from 2000 to 2016.1	Introduction2	Synthetic Approaches to Pyrido[1,2-a]benzimidazoles2.1	Type I: Transition-Metal-Catalyzed Methods2.2	Type II: Metal-Free Approaches3	Conclusion
Investigating Patients' Perception of Microvascular Free Toe Flap for Reconstruction of Amputated Thumbs: A Guide for Surgeons during Informed Consent
Authors: Efanov Johnny , Wong Christopher , Guilbault Clarence , Bou-Merhi Joseph , Harris Patrick , Izadpanah Ali , Danino Michel 
Published: April 2018

Background After thumb amputations, restoration of function and aesthetic can be accomplished with microvascular free toe flaps. However, many patients in clinical practice do not choose this reconstruction despite positive reported outcomes. This study aims to determine patients' perceptions with respect to free toe flaps to improve areas of informed consent.
Methods A retrospective survey was administered to patients with thumb amputations. Participants were required to complete a questionnaire about patient demographics, the Brief Michigan Hand Questionnaire (bMHQ), the standard gamble/time trade-off questionnaires for utility scores, and a questionnaire investigating potential reasons for electing not to undergo a free toe transfer.
Results Thirty patients were enrolled in the study wherein 53% underwent a replantation procedure, 27% a revision amputation, and 20% a delayed reconstruction. Mean normalized score on the bMHQ was recorded as 63.54. Utility questionnaires yielded mean measures of 0.8967 and 0.86 on the standard gamble and time trade-off, respectively. From 14 elements, a majority (87%) stated flap failure as a major source of concern, followed by lack of understanding of risks and benefits (80%) and prolonged hospital stay (53%). Cultural/religious beliefs, aesthetic appearance of the foot, and concerns about footwear were not reported as important reasons in 90, 80, and 79% of patients, respectively.
Conclusion A better understanding of patients' attitudes and beliefs with respect to free toe flaps will allow surgeons to better address their concerns during informed consent. This study emphasizes the importance to discuss about failure rates, risks, and benefits of the operation and prolonged hospital stay.
Decreased Circulating Insulin-Like Growth Factor 1 Levels Are Associated with Cardiac Diastolic Dysfunction in Small for Gestational Age Infants
Authors: Yamazaki Shoko , Obinata Haruka , Hachiya Akira , Kamiya Motoko , Motoki Noriko , Nakamura Tomohiko , Akazawa Yohei 
Published: April 2018

Objective To evaluate the impact of serum insulin-like growth factor-1 (IGF-1) levels on cardiac function in small for gestational age (SGA) infants.
Study Design This is a prospective, observational study. Serum IGF-1 levels at birth and echocardiography measurements at 1 week of age were compared between SGA and appropriate for gestational age (AGA) infants.
Results Thirty-one SGA infants and 27 AGA infants were enrolled. Serum IGF-1 levels were lower in the SGA infants than in the AGA infants. SGA infants had lower mitral lateral annular systolic (S') and early diastolic (E') tissue Doppler imaging velocities compared with AGA infants (S', 5.1 ± 0.9 vs 5.7 ± 1.2 cm/s; E', 6.1 ± 1.5 cm/s vs 7.1 ± 1.3 cm/s; p < 0.05). Serum IGF-1 levels positively correlated with E' velocity in the entire population (r = 0.44, p < 0.001) and in SGA infants (r = 0.39, p < 0.05). In multivariate linear regression analysis, serum IGF-1 and S' velocity were independently associated with E' velocity in the entire population and in SGA infants.
Conclusion Decreased serum IGF-I levels could account for cardiac diastolic dysfunction in SGA infants.
Safety First – Sicherheitsaspekte in der Notfallrettung
Authors: Treffer Dominik , Hossfeld Björn , Helm Matthias , Weißleder Anne 
Published: April 2018

ZusammenfassungDie Beachtung wichtiger Sicherheitsaspekte schützt die Gesundheit der Rettungsfachkräfte und trägt zum Gelingen eines Einsatzes bei. Der Beitrag soll die Beteiligten im Rettungsdienst (Notärzte, Notfallsanitäter, Rettungsassistenten und Rettungssanitäter) für Gefahren im Arbeitsalltag sensibilisieren, Hilfestellungen im Umgang mit diesen Risiken geben und Möglichkeiten zur Prävention aufzeigen, um einen sicheren Einsatzablauf zu ermöglichen.
Speech rhythm in development
Authors: Post Brechtje , Payne Elinor 
Published: April 2018

Perception and production studies of speech rhythm development in
infants and children paint a complex picture of a universal early
perceptual sensitivity to – and production mastery of – cues to
rhythm, while the rate of acquisition of rhythmic properties across
and within languages appears to be typologically and structurally
determined. In this chapter we provide a critical and comprehensive
review of the literature that has led to these insights. We then
explore how child rhythm development can be accommodated in an
integrated approach to speech rhythm in which various structural and
performance aspects interact to determine developmental trajectories
in rhythm acquisition.
The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7α-hydroxyl sulfation of bile acids
Authors: Shimohira Takehiko , Kurogi Katsuhisa , Liu Ming-Cheh , Suiko Masahito , Sakakibara Yoichi 
Published: April 2018

ABSTRACT
Members of the cytosolic sulfotransferase (SULT) SULT2A subfamily are known to be critically involved in the homeostasis of steroids and bile acids. SULT2A8, a 7α-hydroxyl bile acid-preferring mouse SULT, has been identified as the major enzyme responsible for the mouse-specific 7-O-sulfation of bile acids. Interestingly, SULT2A8 lacks a conservative catalytic His residue at position 99th. The catalytic mechanism underlying the SULT2A8-mediated 7-O-sulfation of bile acids thus remained unclear. In this study, we performed a mutational analysis in order to gain insight into this yet-unresolved issue. Results obtained revealed two amino acid residues, His48 and Leu99, that are unique to the mouse SULT2A8, but not other SULTs, are essential for its 7-O-sulfating activity toward bile acids. These findings suggested that substitutions of two amino acids, which might have occurred during the evolution of the mouse SULT2A8 gene, endowed mouse SULT2A8 the capacity to catalyze the 7-O-sulfation of bile acids.
Predicting Viral Failure in Human Immunodeficiency Virus Perinatally Infected Youth With Persistent Low-Level Viremia on Highly Active Antiretroviral Therapy
Authors: Pereira Ruth , Ludwig David A , Mathew Sunil , Flores Claudia , Dominguez Sady , Gonzalez Ivan , Rivera-Hernandez Delia , Scott Gwendolyn B , Mitchell Charles D 
Published: April 2018

AbstractBackgroundLess than optimal adherence with antiretroviral therapy occurs commonly among human immunodeficiency virus HIV)-infected youth. In this study, our object was to identify patterns in the prefailure measurement of viral load (VL) that can reliably predict virological failure (VF) in HIV perinatally infected youth on highly active antiretroviral therapy (HAART).MethodsWe conducted a retrospective chart review of HIV-infected youth with low-level viremia (LLV), defined as an HIV VL between the lower limits of detection (20–75 copies/mL) and 1000 copies/mL. All patients were perinatally infected, under 22 years of age, observed for at least 24 months of consecutive follow-up between May 2008 and July 2014, and received their HIV care at the University of Miami Miller School of Medicine. Of the 349 subjects screened, 100 were eligible for analysis. Virological failure was defined as 3 or more consecutive VLs greater than 1000 copies/mL. Multiple logistic regression and receiver operator characteristic curves were used to identify patterns in VL that ultimately resulted in VF.ResultsFifteen of the 100 patients experienced VF. Higher log10 mean VL, positive slope of the VL (log10 copies/mL per day), and fewer clinic visits were associated with a higher probability of VF. Sensitivity and specificity were .87 and .95, respectively. Resistance was not found in 12 of 15 patients with VF.ConclusionsPatients with LLV that had fewer clinic visits and a trend toward increasing VLs had an increased risk of VF. Noncompliance seems to be a major component of VF. Physicians should emphasize the critical nature of medication adherence.
Did They Write Back? A Mandate Divide in Response to Constituent Casework in Devolved Bodies
Authors: Parsons Alex , Rumbul Rebecca 
Published: April 2018

Abstract
Three devolved bodies in the UK (the Scottish Parliament, the National Assembly for Wales and the London Assembly) use Multi Member Proportional Representation electoral systems. These bodies have two groups of representatives, regional and constituency, elected through different methods. Using a survey of members of the public who contacted their representative, constituency representatives are shown to have a higher response rate across all three bodies, and this effect is isolatable from the role of being a government party. In Scotland, this effect is demonstrable when comparing the behaviour of the same people holding different roles, suggesting that individuals adapt their behaviour to the expectations of the role.
How Formal Parliamentary Negotiation Affects Policy-Making: Evidence from Taiwan
Authors: Huang Shih-hao 
Published: April 2018

AbstractDoes parliamentary negotiation help facilitate legislation? This article applies propensity score matching to empirically investigate the effect of a unique formal negotiation mechanism in Taiwan’s parliament. The analysis of legislative initiatives between 2012 and 2015 shows that the so-called Party Negotiation Mechanism, while being invented to revive legislation amid stalemates, substantially reduces the chance of successful legislation. By extension, the undercut probability of legislative success under Taiwan’s majoritarian system implies that the conventional majoritarian–consensus framework has overlooked a crucial parameter that directly shapes the patterns of policy-making—the internal organisation of a parliament.
Using Analgesics for Emotional Modulation is Associated With Increased Distress, Depression, and Risk of Opioid and Alcohol Misuse
Authors: Vowles Kevin E. , Bailey Robert W. , McEntee Mindy L. , Pielech Melissa , Edwards Karlyn A. , Bolling Lena A. , Rivers W. Evan 
Published: April 2018

Objectives:
It is important to identify aspects of analgesic use that are associated with harm in chronic pain. Historically, the focus has been patterns of use (eg, overuse). This study evaluated another aspect of use—rather than evaluating how analgesics were being used, the primary interest was in why they were being used.

Methods:
In total, 334 analgesic using individuals with chronic pain responded to a pool of items assessing reasons for analgesic use. Measures of pain intensity, distress, depression, and opioid and alcohol misuse were also completed.

Results:
Exploratory factor analyses indicated 3 overarching reasons for use, including taking analgesics: (1) for pain reduction/functional improvement; (2) for emotional modulation/sedation; and (3) to be compliant with prescriber instructions. Correlation and regression analyses indicated that the second factor had the strongest relations with the other measures used, such that greater endorsement of analgesic use for emotional modulation was associated with greater distress, depression, and opioid and alcohol misuse. Using analgesics for pain reduction/functional improvement was associated with greater pain-related distress and depression. Using analgesics to be compliant was not associated with any measure. This pattern of results was generally replicated when a subsample of 131 individuals taking opioids was examined.

Discussion:
Results support the utility of examining reasons for analgesic use; use to achieve emotional modulation/sedation may be particularly associated with risk. The data also provide support for the questionnaire developed, the Reasons for Analgesic Use Measure.