bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insecticidal and antifeeding activity of Perilla frutescens‐derived material against the diamondback moth, Plutella xylostella L
Authors: Kim Hyun Kyung , Cho Sun‐Ran , Kim Gil‐Hah 
Published: December 2018

AbstractInsecticidal and antifeeding activities against Plutella xylostella were observed using whole‐plant‐derived Perilla frutescens material. The active ingredient in P. frutescens was identified by spectroscopic analysis as the sesquiterpenoid α‐farnesene, which showed insecticidal activity against third‐instar larva of P. xylostella in a leaf‐dipping bioassay based on 24‐h LD50 values (LD50 = 53.7 ppm). The feeding inhibition rate of α‐farnesene was 82.98% against P. xylostella at 10 ppm, and the antifeeding responses were determined using an oscilloscope to detect electrophysiological responses. The electrophysiological responses of the medial styloconic sensillum (MSS) were approximately 7‐fold more sensitive at 100 ppm than those of the lateral styloconic sensillum (LSS). These results suggest that the insecticidal and antifeeding effect of α‐farnesene, which is a P. frutescens‐derived material, can be used as a potential control agent for P. xylostella.
Occurrence of Heterocyclic Amines in Commercial Fast‐Food Meat Products Available on the Chinese Market and Assessment of Human Exposure to these Compounds
Authors: Khan Iftikhar Ali , Yiqun Cheng , Zongshuai Zhu , Ijaz Muhammad Umair , Brohi Sarfaraz Ahmed , Ahmad Muhammad Ijaz , Shi Caiyue , Hussain Muzahir , Huang Jichao , Huang Ming 
Published: December 2018

AbstractHeterocyclic amines (HCAs) have been identified as highly mutagenic and are risk factors for human cancer. In recent years, the intake of fast‐food meat products has increased exponentially due to their convenience. Therefore, it is important to assess the health risks of HCAs and provide useful public dietary guidelines. Eight fast‐food meat products were selected from the Chinese market, including chicken, beef, and fish, to evaluate their health risk in conjunction with HCAs. Crispy chicken drumsticks contained the maximum level of total HCAs (24.18 ± 3.57 ng/g), followed by crispy fried chicken burgers (19.99 ± 1.41 ng/g) and traditional Chinese nuggets (19.17 ± 1.23 ng/g), whereas shrimp cake burgers had the lowest levels (13.17 ± 1.77 ng/g). Crispy chicken drumsticks (men: 169.12 ng/day, women: 108.70 ng/day), hot chicken wings (men: 126.32 ng/day, women: 142.11 ng/day), and crispy fried chicken burgers (men: 129.78 ng/day, women: 59.91 ng/day) were found to provide the highest dietary intake of HCAs in both genders, which may lead to an increase in colorectal and breast cancers.Practical ApplicationsThe rapid expansion of the Chinese fast‐food industry has promoted serious health problems, such as colorectal cancer and some cardiovascular diseases. Several epidemiological studies revealed that a high intake of processed meats may increase the risk of cancer in humans because cooking food proteins, such as meat, at high temperatures could produce high levels of carcinogenic compounds, such as HCAs. Because of the vast variation in eating habits, preparation methods and the frequency of meat consumption, it is important to evaluate the accurate level of HCAs in commercially available fast‐food meat products with the aim to clarify the association between processed meats and the health risk.
Women‘s experiences of postterm induction of labor: A systematic review of qualitative studies
Authors: Lou Stina , Hvidman Lone , Uldbjerg Niels , Neumann Lone , Jensen Trine Fritzner , Haben Joke‐Gesine , Carstensen Kathrine 
Published: December 2018

AbstractBackgroundOver the last decade, induction of labor (IOL) in postterm pregnancies has increased. Studies have shown the medical advantages of postterm IOL, but less is known about the perspectives of the pregnant women. This review aimed to summarize the current qualitative evidence on women’s experience of postterm IOL.MethodsA systematic literature search was performed in three databases. A total of 3193 publications were identified, but only eight studies met the inclusion criteria. Thematic analysis guided the data extraction and synthesis. The Confidence in the Evidence for Reviews of Qualitative research (CERQual) approach was used to assess confidence in the findings.ResultsThree major findings were identified. First, for some women, IOL required a shift in expectations because the hope of spontaneous labor had to be given up. Second, the IOL decision was considered a recommendation from health care professionals and was experienced as a nondecision. Finally, the induction process was experienced as a sequential set of steps where the women were expected to fit into the existing hospital organization. The CERQual assessment suggested moderate confidence in all findings.DiscussionThe negative experiences identified in this review can be greatly reduced by a communicative and patient‐centered approach. To support informed choice and shared decision making, women need high‐quality, unbiased information about IOL, alternative options, and potential outcomes, in addition to time for reflection on their personal values and preferences. Women may need a professionally initiated and supported opportunity to re‐evaluate their hopes and expectations before IOL.
The development of mental rotation abilities through robotics‐based instruction: An experience mediated by gender
Authors: González‐Calero José Antonio , Cózar Ramón , Villena Rafael , Merino José Miguel 
Published: December 2018

AbstractThe research literature on the topic of “spatial ability” reveals that it has a major influence on achievement in the fields of science, technology, engineering and mathematics. Additionally, previous studies indicate the existence of a gender gap in spatial ability in favour of males. Mental rotation, one subskill of spatial ability, is an area in which gender differences are greater. At the same time, educational robotics is seen as one of the more promising technologies in educational contexts for the future. We conducted a quasi‐experimental study with 142 seven‐ and eight‐year‐old students aimed at analysing whether robotics‐based instruction may produce greater learning gains on mental rotation abilities compared to traditional instruction. The intervention was developed in the context of map‐reading tasks, which are part of the curricular content in Mathematics and Social Sciences at this age. The results showed that for males, the robotics‐based instruction promoted a significantly greater improvement in students’ mental rotation abilities compared to the control group. By contrast, no significant differences were observed for females. Although this study provides empirical evidence of the potential of robotics‐based instruction, future studies need to deeply analyse the existence of gender differences in the learning gains obtained through educational robotics.
Inflammatory and regulatory CCL and CXCL chemokine and cytokine cellular responses in patients with patentMansonella perstansfilariasis
Authors: Wangala B , Gantin RG , Voßberg P S , Vovor A , Poutouli WP , Komlan K , Banla M , Köhler C , Soboslay PT 
Published: December 2018

SummaryMansonella perstans (Mp) filariasis is present in large populations in sub-Saharan Africa, and to what extent patent Mp infection modulates the expression of immunity in patients, notably their cellular cytokine and chemokine response profile, remains not well known. We studied the spontaneous and inducible cellular production of chemokines (C-X-C motif) ligand 9 (CXCL9) [monokine induced by interferon (IFN)-γ (MIG)], CXCL-10 [inducible protein (IP)-10], chemokine (C-C motif) ligand 24 (CCL24) (eotaxin-2), CCL22 [macrophage-derived chemokine (MDC)], CCL13 [monocyte chemotactic protein-4 (MCP-4)], CCL18 [pulmonary and activation-regulated chemokine (PARC)], CCL17 [thymus- and activation-regulated chemokine (TARC)] and interleukin (IL)-27 in mansonelliasis patients (Mp-PAT) and mansonelliasis-free controls (CTRL). Freshly isolated peripheral mononuclear blood cells (PBMC) were stimulated with helminth, protozoan and bacterial antigens and mitogen [phytohaemagglutinin (PHA)]. PBMC from Mp-PAT produced spontaneously (without antigen stimulation) significantly higher levels of eotaxin-2, IL-27, IL-8, MCP-4 and MDC than cells from CTRL, while IFN-γ-IP-10 was lower in Mp-PAT. Helminth antigens activated IL-27 and MCP-4 only in CTRL, while Ascaris antigen, Onchocerca antigen, Schistosoma antigen, Entamoeba antigen, Streptococcus antigen, Mycobacteria antigen and PHA stimulated MIG release in CTRL and Mp-PAT. Notably, Entamoeba antigen and PHA strongly depressed (P &lt; 0·0001) eotaxin-2 (CCL24) production in both study groups. Multiple regression analyses disclosed in Mp-PAT and CTRL dissimilar cellular chemokine and cytokine production levels being higher in Mp-PAT for CCL24, IL-27, IL-8, MCP-4, MDC and PARC (for all P &lt; 0·0001), at baseline (P &lt; 0·0001), in response to Entamoeba histolytica strain HM1 antigen (EhAg) (P &lt; 0·0001), Onchocerca volvulus adult worm-derived antigen (OvAg) (P = 0·005), PHA (P &lt; 0·0001) and purified protein derivative (PPD) (P &lt; 0·0001) stimulation. In Mp-PAT with hookworm co-infection, the cellular chemokine production of CXCL10 (IP-10) was diminished. In summary, the chemokine and cytokine responses in Mp-PAT were in general not depressed, PBMC from Mp-PAT produced spontaneously and selectively inducible inflammatory and regulatory chemokines and cytokines at higher levels than CTRL and such diverse and distinctive reactivity supports that patent M. perstans infection will not polarize innate and adaptive cellular immune responsiveness in patients.
Complications related to totally implantable venous access devices in children and adults following lung transplantation
Authors: Cho Joshua K. , Acord Michael , Goldfarb Samuel B. , Reddy Shilpa N. , Goldberg Hilary J. , Courtwright Andrew M. 
Published: December 2018

AbstractIntroductionTotally implantable venous access devices (TIVADs) are the preferred devices for patients with advanced lung disease who require long‐term venous access. The primary purpose of this study was to describe the natural history of TIVADs left in place at the time of transplant.MethodsThis multicenter retrospective cohort study evaluated pediatric and adult lung transplant recipients from 5/5/2005 to 12/31/17 with pretransplant TIVAD. Incident rates (IR) for infectious and mechanical complications were calculated. Poisson regression models were used to identify TIVAD characteristics associated with complications.ResultsOf 1253 transplant recipients, 82 (6.5%) had pretransplant TIVAD. Five (6.1%) TIVADs were removed at transplantation. Fifty‐five (67.1%) TIVADs were eventually removed, most commonly because they were no longer required (50.9%) or because of infection (25.5%). Overall incident rates (IR) of infectious or mechanical complications were 0.33 and 0.14, respectively. The IR of infection was highest within one year of transplant, particularly during the index hospitalization (IR = 1.67). Youngest tertile (<22 years) had the lowest incident rate ratio of TIVAD infections (IRR = 0.22).ConclusionAlthough TIVAD complication rates in lung transplant recipients are similar to non‐transplant and other immunocompromised patients, TIVAD removal at transplant or within the first post‐transplant year may minimize the risk of TIVAD infections.
Dental trauma on primary teeth at different root resorption stages—A dynamic finite element impact analysis of the effect on the permanent tooth germ
Authors: Vilela Andomar B. F. , Soares Priscilla B. F. , de Oliveira Fabiana S. , Garcia‐Silva Tales C. , Estrela Carlos , Versluis Antheunis , Soares Carlos J. 
Published: December 2018

AbstractBackground/AimDental trauma is a common emergency in children with primary teeth. The aim of this study was to determine stress propagation to the permanent tooth germ and surrounding bone and soft tissues during dental trauma to primary central incisors with three levels of physiological root resorption.Material and MethodsStresses were determined using finite element analysis (FEA). Cross‐sectional models were created using cone‐beam computed tomography images of 3.5, 5, and 6 years olds, representing three different physiological root resorption stages of a maxillary primary central incisor. The models included periodontal ligament, bone, and soft tissues. An impact with an asphalt block moving at 1 m/s,was simulated for two impact two directions, frontal on the labial tooth surface, and on the incisal edge. Stresses and strains were recorded during impact.ResultsThe impact caused stress concentrations in the surrounding bone and soft tissues and permanent tooth germ, regardless of the direction of impact and the primary tooth resorption stage. Impact stresses in dental follicles and surrounding bone increased in models with more physiological root resorption of the primary tooth. Incisal impact generated higher stress concentrations in surrounding bone and soft tissues and permanent tooth germ regardless of physiological root resorption stage. The primary incisor with no physiological root resorption showed high stress concentrations at its root apex.ConclusionDuring impact to a primary incisor, stresses most significant for potential damage to the formation of permanent enamel and dentin were at the dental follicle and surrounding bone tissue with the three levels of physiological root resorption.
Acute ischaemic lesions are associated with cortical superficial siderosis in spontaneous intracerebral hemorrhage
Authors: Revel‐Mouroz P. , Viguier A. , Cazzola V. , Calviere L. , Patsoura S. , Rousseau V. , Sommet A. , Albucher J. F. , Cognard C. , Olivot J. M. , Bonneville F. , Raposo N. 
Published: December 2018

Background and purposeDiffusion‐weighted imaging (DWI) commonly detects acute ischaemic lesions in patients with acute intracerebral hemorrhage (ICH), especially with cerebral amyloid angiopathy (CAA). We investigated the relationship between cortical superficial siderosis (cSS), a neuroimaging marker of CAA, and DWI lesions in patients with acute ICH.MethodsWe conducted a retrospective analysis of prospectively collected data from consecutive patients with acute supratentorial ICH who underwent brain magnetic resonance imaging within 10 days after symptom onset. Magnetic resonance imaging scans were analyzed for DWI lesions, cSS and other markers for small‐vessel disease. Univariate and multivariate analyses were performed to assess the association between cSS and DWI lesions.ResultsAmong 246 ICH survivors (mean age 71.4 ± 12.6 years) who were enrolled, 126 had lobar ICH and 120 had deep ICH. Overall, DWI lesions were observed in 38 (15.4%) patients and were more common in patients with lobar ICH than deep ICH (22.2% vs. 8.3%; P = 0.003). In multivariate logistic regression analysis, the extent of white matter hyperintensities [odds ratio (OR), 1.29; 95% confidence interval (CI), 1.05–1.58; P = 0.02] and cSS severity (focal cSS: OR, 3.54; 95% CI, 1.28–9.84; disseminated cSS: OR, 4.41; 95% CI, 1.78–10.97; P = 0.001) were independently associated with the presence of DWI lesions.ConclusionsDiffusion‐weighted imaging lesions are more frequently observed in patients with acute lobar ICH than in those with deep ICH. cSS severity and white matter hyperintensity extent are independent predictors for the presence of DWI lesions, suggesting that CAA may be involved in the pathogenesis of DWI lesions associated with acute ICH.
Fund selection, style allocation, and active management abilities: Evidence from funds of hedge funds’ holdings
Authors: Gao Chao , Haight Timothy D. , Yin Chengdong 
Published: December 2018

AbstractThis study examines whether funds of hedge funds (FOHFs) provide superior before‐fee performance through managers’ fund selection, style allocation, and active management abilities. Using reported holdings of Securities and Exchange Commission–registered FOHFs, we find that FOHF managers have fund selection abilities, as hedge funds held by FOHFs outperform their style indices and over half of the individual hedge funds in the Lipper Trading Advisor Selection System (TASS) database. We also find that FOHF managers add value through active management of FOHFs’ holdings, while evidence on their style allocation abilities is mixed. Our findings suggest that FOHFs generate superior before‐fee performance and that FOHF managers’ skillset is broader than previously documented. Thus, our study helps explain why FOHFs continue to survive and suggests that FOHF fee structure reform merits consideration.
Elevated CO2 impairs olfactory‐mediated neural and behavioral responses and gene expression in ocean‐phase coho salmon (Oncorhynchus kisutch)
Authors: Williams Chase R. , Dittman Andrew H. , McElhany Paul , Busch D. Shallin , Maher Michael T. , Bammler Theo K. , MacDonald James W. , Gallagher Evan P. 
Published: December 2018

AbstractElevated concentrations of CO2 in seawater can disrupt numerous sensory systems in marine fish. This is of particular concern for Pacific salmon because they rely on olfaction during all aspects of their life including during their homing migrations from the ocean back to their natal streams. We investigated the effects of elevated seawater CO2 on coho salmon (Oncorhynchus kisutch) olfactory‐mediated behavior, neural signaling, and gene expression within the peripheral and central olfactory system. Ocean‐phase coho salmon were exposed to three levels of CO2, ranging from those currently found in ambient marine water to projected future levels. Juvenile coho salmon exposed to elevated CO2 levels for 2 weeks no longer avoided a skin extract odor that elicited avoidance responses in coho salmon maintained in ambient CO2 seawater. Exposure to these elevated CO2 levels did not alter odor signaling in the olfactory epithelium, but did induce significant changes in signaling within the olfactory bulb. RNA‐Seq analysis of olfactory tissues revealed extensive disruption in expression of genes involved in neuronal signaling within the olfactory bulb of salmon exposed to elevated CO2, with lesser impacts on gene expression in the olfactory rosettes. The disruption in olfactory bulb gene pathways included genes associated with GABA signaling and maintenance of ion balance within bulbar neurons. Our results indicate that ocean‐phase coho salmon exposed to elevated CO2 can experience significant behavioral impairments likely driven by alteration in higher‐order neural signal processing within the olfactory bulb. Our study demonstrates that anadromous fish such as salmon may share a sensitivity to rising CO2 levels with obligate marine species suggesting a more wide‐scale ecological impact of ocean acidification.
Thermal constraints on body size depend on the population’s position within the species’ thermal range in temperate songbirds
Authors: Dubos Nicolas , Dehorter Olivier , Henry Pierre‐Yves , Le Viol Isabelle 
Published: December 2018

AbstractAimThere is mounting evidence that climate warming can induce morphological changes locally, particularly size reduction. However, the direction of thermal stress may differ between climatic regions. We predicted that morphological response to temperature fluctuations should vary throughout species ranges, depending on the local climate. Hot temperature anomalies are expected to induce size reduction in hot regions where species live close to their upper thermal limit, whereas size stasis (or increase) would be expected in cold regions, where species live close to their lower thermal limit.LocationFrance (204 sites).Time period2000–2014 springs.Major taxa studiedSongbird species (n = 9).MethodsWe tested whether the effect of temperature anomalies on juvenile body size varied along an 11 °C thermal gradient.ResultsIn warmer springs, juveniles were larger overall at the coldest sites, but this effect decreased toward the hottest sites, becoming negative for two species.Main conclusionsWarming should induce body size increases more frequently at the cold edge of species distribution ranges, and rather body size declines at the hot edg. The climate dependency of the effect of weather fluctuations on body size is still under‐acknowledged, and the pattern identified deserves to be investigated over broader climatic gradients and taxonomic coverage. Climate‐driven changes in body size are therefore not uniform across climatic regions and within species ranges.
Uptake and virological outcomes of single‐ versus multi‐tablet antiretroviral regimens among treatment‐naïve youth in the HIV Research Network
Authors: Griffith DC , Farmer C , Gebo KA , Berry SA , Aberg J , Moore RD , Gaur AH , Mathews WC , Beil R , Korthuis PT , Nijhawan AE , Rutstein RM , Agwu AL ,   for the HIV Research Network
Published: December 2018

ObjectivesSeveral single‐tablet regimens (STRs) are now available and are recommended for first‐line antiretroviral therapy (ART); however, STR use for youth with HIV (YHIV) has not been systematically studied. We examined the characteristics associated with initiation of STRs versus multi‐tablet regimens (MTRs) and the virological outcomes for youth with nonperinatally acquired HIV (nPHIV).MethodsA retrospective cohort study of nPHIV youth aged 13–24 years initiating ART between 2006 and 2014 at 18 US HIV clinical sites in the HIV Research Network was performed. The outcomes measured were initiation of STRs versus MTRs, virological suppression (VS) at 12 months, and time to VS. Demographic and clinical factors associated with initiation of STR versus MTR ART and VS (< 400 HIV‐1 RNA copies/mL) at 12 months after initiation were assessed using multivariable logistic regression. Cox proportional hazards regression was used to assess VS within the first year.ResultsOf 987 youth, 67% initiated STRs. Of the 589 who had viral load data at 1 year, 84% of those on STRs versus 67% of those on MTRs achieved VS (P < 0.01). VS was associated with STR use [adjusted odds ratio (AOR) 1.61; 95% confidence interval (CI) 1.01–2.58], white (AOR 2.41; 95% CI 1.13–5.13) or Hispanic (AOR 2.38; 95% CI 1.32–4.27) race/ethnicity, and baseline CD4 count 351–500 cells/μL (AOR 1.94; 95% CI 1.18–3.19) and > 500 cells/μL (AOR 1.76; 95% CI 1.0–3.10). STR use was not associated with a shorter time to VS compared with MTR use [hazard ratio (HR) 1.07; 95% CI 0.90–1.28].ConclusionsUse of STR was associated with a greater likelihood of sustained VS 12 months after ART initiation in YHIV.
Cultural Capital of Recruitment Decision‐Makers and its Influence on their Perception of Person‐Organisation Fit of Skilled Migrants
Authors: Almeida Shamika , Waxin Marie‐France , Paradies Yin 
Published: December 2018

ABSTRACTThis article examines how recruitment decision‐makers’ cultural capital can influence their concerns about the organizational fit of skilled migrants (SM). We used survey data and interviews with Information Technology organizations in Australia. The study highlights the decision‐makers’ relatively poor understanding of non‐western cultures and how it negatively influences their perception of candidates from non‐western backgrounds. Furthermore, this study also notes how organisational cultural values and decision‐makers’ exposure to diverse cultures can influence their assumptions about the value of international qualifications and work experiences. Similarly, it can also influence how they assess the perception of fit based on a candidate's appearance and communication style. Consequently, the cognitive biases and judgements of resource acquisition managers can act as gatekeepers who keep non‐western SM out of the organizational resource pool. The article concludes by noting the importance of human resource practices that seek to develop cultural capital of decision‐makers.