bluuebunny/crossref_metadata_2025_split huggingface dataset:
A funerary monument on the Capitoline: architecture and painting in mid-Republican Rome, between Etruria and Greece
Authors: Tucci Pier Luigi 
Published: October 2018

The debate on the relationships between Rome, Italy, and the Mediterranean world in the Archaic and mid-Republican periods remains very lively. Complementing the most recent discoveries and interpretations, I present two unknown mid-Republican documents from the Arx, the N summit of the Capitoline hill (fig. 1). Excavations for the Monument to Victor Emmanuel II brought to light after 1887 many walls and artifacts, which have been studied almost exclusively to produce archaeological maps or catalogues of objects, but the structures sealed beneath the basilica of Santa Maria in Aracoeli toward the end of the 13th c., rediscovered in the 1980s and surveyed by the present author since 2001, shed new light on a number of religious, historical, topographical, architectural and art-historical issues.The new archaeological evidence may be summarized as follows. In the 1st c. B.C., an aristocratic domus set on three levels occupied the NW sector of the Arx; it was remodeled in the Flavian and Severan periods (figs. 2-3). Apparently a location of the temple of Juno Moneta on the site of the Aracoeli must be ruled out. Among the structures still preserved beneath the basilica, which include an Imperial-era wall with huge curvilinear spurs that can be associated with the Iseum Capitolinum, we may mention an ashlar wall in blocks of Grotta Oscura tuff (a stone available after the defeat of Veii in 397 B.C.) that constituted the façade of a monument with a false arch dating from the 4th c. B.C. (fig. 2).
Two portraits from Aphrodisias: late-antique re-visualizations of traditional culture-heroes?
Authors: Lenaghan Julia 
Published: October 2018

The “Last Statues of Antiquity”, the collaborative project directed by R. R. R. Smith and B. Ward-Perkins, gathers into a single database all extant late-antique portraits. As a member of the research team, I was given the opportunity to study all the portraits that are either known or conjectured to represent traditional culture-heroes. This exercise gave me “new” eyes for viewing two “old” portraits from Aphrodisias, until now not identifiable. One, excavated in 1982, is a clean-shaven portrait, once fancifully identified as Julius Caesar (fig. 2); the other, first published in 1958, is a bearded portrait broken off a bust (fig. 13).Neither of these two heads is immediately recognizable as a representation of any known individual by the scholarly method which works so well with portraits of Early and High Imperial Roman emperors: that is, neither is identifiable as following any known “portrait type” by the application of the rules of “Kopienkritik”, whereby a scholar establishes the indisputable dependence of two sculptures on a model by finding precisely shared details between two heads — details of hair locks, face, pose, or attributes. In late antiquity, however, fidelity to inherited models was more fluid, and a bold re-interpretation — in terms of contemporary portrait-style — was perhaps even to be desired. This is particularly true in the case of the portraits of traditional culture-heroes: the many highly variable portraits of Menander (here fig. 6) or of Socrates may serve to demonstrate this point.
Ruptured mitral valves chordae tendineae around a convalescent infant with acute Kawasaki disease
Authors: Tsuda Etsuko , Negishi Jun , Miike Hikari , Kurosaki Kenichi 
Published: October 2018

AbstractSevere valvulitis owing to acute Kawasaki disease leading to severe mitral regurgitation is a rare event in infants. Further, there is less information about underlying ruptured mitral chordae tendineae causing severe mitral regurgitation. We encountered ruptured mitral chordae tendineae in three female patients after Kawasaki disease. The age at the onset of Kawasaki disease ranged from 3 to 8 months, and detection of ruptured mitral chordae tendineae was from 24 to 90 days. Two patients had acute heart failure, and one was asymptomatic. One patient underwent mitral annuloplasty, and the others responded to medication. These ruptured mitral chordae tendineae occurred after the remission of the initial acute Kawasaki disease, in the early course and the convalescent of acute Kawasaki disease. Further, the recurrent fever was also detected in them. The ruptured mitral chordae tendineae in an infant within 6 months can be detected by systolic heart murmur around the convalescent stage of acute Kawasaki disease, although the prevalence is very low.
Deleterious Impact of Expressive Suppression on Test Performance Persists at One-Year Follow-Up in Community-Dwelling Older Adults
Authors: Suchy Yana , Niermeyer Madison Amelia , Franchow Emilie Irene , Ziemnik Rosemary 
Published: October 2018

AbstractObjectives:Expressive suppression (ES) is an emotion-regulation strategy that is associated with poorer performance on subsequently administered tests of executive functioning (EF). It is not known, however, how far into the future ES interferes with EF. This study examined whether (a) ES negatively affects performance on EF tests repeated 1 year after the initial administration (presumably through interference with learning, leading to a reduced practice effect), and (b) whether such an effect, if seen, is unique to EF or whether it also affects lower-order cognitive processes needed for EF test performance.Methods:Sixty-six non-demented community-dwelling older adults were randomly assigned to either an ES group or control group. Executive and non-executive tests were administered before and immediately following the exposure to an emotionally evocative video, and then again at 1-year follow-up. Groups were compared at 1-year follow-up on tests of EF and lower-order processes, to examine whether the previously demonstrated impact of ES on EF is evident only immediately following the experimental manipulation (Franchow & Suchy, 2017), or also at 1-year follow-up.Results:The results showed that participants who engaged in ES continued to exhibit poorer performance on EF tests 1 year later. This effect was not present for performance on tests of lower-order processes.Conclusions:These results suggest that the use of ES before an EF task can interfere with the ability to benefit from exposure to that task, thereby negatively affecting future performance. (JINS, 2019, 25, 29–38)
REXPANSIONS OF NONDETERMINISTIC MATRICES AND THEIR APPLICATIONS IN NONCLASSICAL LOGICS
Authors: AVRON ARNON , ZOHAR YONI 
Published: October 2018

AbstractThe operations of expansion and refinement on nondeterministic matrices (Nmatrices) are composed to form a new operation called rexpansion. Properties of this operation are investigated, together with their effects on the induced consequence relations. Using rexpansions, a semantic method for obtaining conservative extensions of (N)matrix-defined logics is introduced and applied to fragments of the classical two-valued matrix, as well as to other many-valued matrices and Nmatrices. The main application of this method is the construction and investigation of truth-preserving ¬-paraconsistent conservative extensions of Gödel fuzzy logic, in which ¬ has several desired properties. This is followed by some results regarding the relations between the constructed logics.
Transgenerational effects of maternal bisphenol: a exposure on offspring metabolic health
Authors: Bansal A. , Li C. , Xin F. , Duemler A. , Li W. , Rashid C. , Bartolomei M. S. , Simmons R. A. 
Published: October 2018

AbstractExposure to the endocrine disruptor bisphenol A (BPA) is ubiquitous and associated with health abnormalities that persist in subsequent generations. However, transgenerational effects of BPA on metabolic health are not widely studied. In a maternal C57BL/6J mice (F0) exposure model using BPA doses that are relevant to human exposure levels (10 μg/kg/day, LowerB; 10 mg/kg/day, UpperB), we showed male- and dose-specific effects on pancreatic islets of the first (F1) and second generation (F2) offspring relative to controls (7% corn oil diet; control). In this study, we determined the transgenerational effects (F3) of BPA on metabolic health and pancreatic islets in our model. Adult F3 LowerB and UpperB male offspring had increased body weight relative to Controls, however glucose tolerance was similar in the three groups. F3 LowerB, but not UpperB, males had reduced β-cell mass and smaller islets which was associated with increased glucose-stimulated insulin secretion. Similar to F1 and F2 BPA male offspring, staining for markers of T-cells and macrophages (CD3 and F4/80) was increased in pancreas of F3 LowerB and UpperB male offspring, which was associated with changes in cytokine levels. In contrast to F3 BPA males, LowerB and UpperB female offspring had comparable body weight, glucose tolerance and insulin secretion as Controls. Thus, maternal BPA exposure resulted in fewer metabolic defects in F3 than F1 and F2 offspring, and these were sex- and dose-specific.
Magnetic Properties of Deep‐Sea Sediments From the North Pacific: A Proxy of Glacial Deep‐Water Ventilation
Authors: Shin Ji Young , Yu Yongjae , Seo Inah , Hyeong Kiseong , Lim Dhongil , Kim Wonnyon 
Published: October 2018

AbstractThe magnetic properties of deep‐sea sediments in the North Pacific vary in sync with glacial‐interglacial climatic changes and have thus been considered as a paleoclimate indicator. However, the causes of these variations in magnetic properties, including the concentration, grain size, and mineralogy of magnetic minerals, remain poorly understood. Here we investigate the magnetic properties of deep‐sea sediments recovered from the Shatsky Rise in the North Pacific to investigate the cause of the variability associated with glacial‐interglacial cycles. Compared to the potential sediment provenances, the interglacial‐stage and more than half of the glacial‐stage sediments reveal magnetic mineralogical properties (S ratio and L ratio) of the Gobi and Taklimakan deserts, probably indicating dust from the both sources. During glacials, an abrupt decrease in the concentration of magnetic minerals is associated with increases in the average grain size and in the proportion of hematite relative to magnetite. The changes during glacials are mostly a result of dissolutions of magnetite by exposure to ambient ocean environments after deposition. Both magnetic and geochemical proxies validate that poor ventilation of the glacial deep waters in the North Pacific possibly induced iron‐reducing conditions. With comprehensive compilation with the S‐ratio data in the North Pacific sediments, our result indicates that the poorly ventilated deep waters reached up to water depths of ~2,500 m during glacials.
An Integrated Hydrological Model for the Restoration of Ecosystems in Arid Regions: Application in Zhangye Basin of the Middle Heihe River Basin, Northwest China
Authors: Liu Minghuan , Xu Xu , Jiang Yao , Huang Quanzhong , Huo Zailin , Huang Guanhua 
Published: October 2018

AbstractRiver basins in or across arid regions have been facing intensified water scarcity and ecological problems, mainly due to the intense irrigated agriculture. Integrating the multiprocesses in hydrological cycle is quite necessary to make reasonable management strategies. In this paper, an integrated multiprocess hydrological model was proposed by coupling river water flow, groundwater flow, canal conveyance, and vadose water flow processes. It was applied to the Zhangye basin of middle Heihe River basin for searching management strategies to restore the ecosystems (i.e., ensure surface runoff into downstream and also recover local groundwater levels). The integrated model was calibrated and validated during 2005‐2007 and 2008‐2010, respectively. Simulation of groundwater levels (GWLs, 32 wells) and surface runoff both matched well with the observed values, with Nash and Sutcliffe model efficiency > 0.38 and R2 > 0.57. Then various scenarios were designed with considering five alternatives of different farmland area decrease and three alternatives of groundwater exploitation. Responses of surface runoff and GWLs were predicted for 20 years. Surface runoff change was compared with the water diversion curve, and GWL recovery was also discussed. Results revealed that ecosystems could not be restored with current agricultural area, even shutting down groundwater abstraction for irrigation. A decrease of about 30% of farmland area and using surface river water instead of pumping groundwater for irrigation could satisfy water diversion demand with only a slight GWL decline. Furthermore, the extra irrigation with diverted surface water during nongrowing season could further lead to the recovery of GWLs while without causing negative effects on surface runoff.
Simple Parameterization of Aerodynamic Roughness Lengths and the Turbulent Heat Fluxes at the Top of Midlatitude August‐One Glacier, Qilian Mountains, China
Authors: Guo Shuhai , Chen Rensheng , Liu Guohua , Han Chuntan , Song Yaoxuan , Liu Junfeng , Yang Yong , Liu Zhangwen , Wang Xiqiang , Liu Xiaojiao , Wang Lei , Zheng Qin 
Published: October 2018

AbstractThe fluxes of sensible heat (H) and latent heat (LE), which are generally the important parts of the energy and mass balances over glacier surfaces, are widely quantified by the bulk method. However, due to the difficulty of determining the aerodynamic roughness length z0m in this method, H and LE values may still have large uncertainties with significant inaccuracy. To acquire reliable varying and intrinsic z0m values, new simpler parameterizations for z0m values at different ranges of the friction velocity u*b were fitted in this study. The method was implemented using the related meteorological data and glacial sublimation/condensation measured at the top of the August‐one glacier (4817 m asl) in the Qilian Mountains from 1 July 2016 to 15 August 2017. The parameterization shows that z0m increased sharply when u*b exceeded 0.43 m/s (the approximate threshold value) and that the effect of snowdrift was slight for the hourly z0m values in the range 0.15 ≤ u*b ≤ 0.43 m/s, which could thus be used to calculate the daily z0m. During the wet period (1 July to 24 September 2016 and 5 May to 15 August 2017), the turbulent fluxes calculated by the bulk method showed that net radiation Rnet was the primary source of surface energy (60.7 w/m2), whereas during the dry period (25 September 2016 to 4 May 2017), the main heat sink was the positive H (28.5 w/m2) rather than the negative Rnet (−10.0 w/m2).
Acute microglia ablation induces neurodegeneration in the somatosensory system
Authors: Rubino Stephen J. , Mayo Lior , Wimmer Isabella , Siedler Victoria , Brunner Florian , Hametner Simon , Madi Asaf , Lanser Amanda , Moreira Thais , Donnelly Dustin , Cox Laura , Rezende Rafael Machado , Butovsky Oleg , Lassmann Hans , Weiner Howard L. 
Published: October 2018

AbstractPrevious studies have reported that microglia depletion leads to impairment of synapse formation and these cells rapidly repopulate from CNS progenitors. However, the impact of microglia depletion and repopulation in the long-term state of the CNS environment has not been characterized. Here, we report that acute and synchronous microglia depletion and subsequent repopulation induces gray matter microgliosis, neuronal death in the somatosensory cortex and ataxia-like behavior. We find a type 1 interferon inflammatory signature in degenerating somatosensory cortex from microglia-depleted mice. Transcriptomic and mass cytometry analysis of repopulated microglia demonstrates an interferon regulatory factor 7-driven activation state. Minocycline and anti-IFNAR1 antibody treatment attenuate the CNS type 1 interferon-driven inflammation, restore microglia homeostasis and reduce ataxic behavior. Neither microglia depletion nor repopulation impact neuropathology or T-cell responses during experimental autoimmune encephalomyelitis. Together, we found that acute microglia ablation induces a type 1 interferon activation state of gray matter microglia associated with acute neurodegeneration.
Machine-learning the configurational energy of multicomponent crystalline solids
Authors: Natarajan Anirudh Raju , Van der Ven Anton 
Published: October 2018

AbstractMachine learning tools such as neural networks and Gaussian process regression are increasingly being implemented in the development of atomistic potentials. Here, we develop a formalism to leverage such non-linear interpolation tools in describing properties dependent on occupation degrees of freedom in multicomponent solids. Symmetry-adapted cluster functions are used to differentiate distinct local orderings. These local features are used as input to neural networks that reproduce local properties such as the site energy. We apply the technique to reproduce a synthetic cluster expansion Hamiltonian with multi-body interactions, as well as the formation energies calculated from first-principles for the intercalation of lithium into TiS2. The formalism and results presented here show that complex multi-body interactions may be approximated by non-linear models involving smaller clusters.
Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA
Authors: Bjune Katrine , Wierød Lene , Naderi Soheil 
Published: October 2018

AbstractLow-density lipoprotein receptor (LDLR) is a key regulator of the metabolism of plasma low-density lipoprotein cholesterol (LDL-C), the elevated levels of which are associated with an increased risk of cardiovascular disease. Therefore, enhancing LDLR expression represents a potent treatment strategy for hypercholesterolemia. Here, we report that in cultured human hepatoma cells, triciribine, a highly selective AKT inhibitor, increases the stability of LDLR mRNA, an event that translates into upregulation of cell-surface LDLR levels and induction of cellular LDL uptake. This effect of triciribine requires ERK activity and is partially dependent on the intervening sequence between the AU-rich elements ARE3 and ARE4 in LDLR 3′UTR. We also show that triciribine downregulates the expression of PCSK9 mRNA and blunts the secretion of its protein. Notably, triciribine was found to potentiate the effect of mevastatin on LDLR protein levels and activity. We also show that primary human hepatocytes respond to triciribine by increasing the expression of LDLR. Furthermore, a pilot experiment with mice revealed that a two-weeks treatment with triciribine significantly induced the hepatic expression of LDLR protein. These results identify triciribine as a novel LDLR-elevating agent and warrant further examination of its potential as a hypocholesterolemic drug either as monotherapy or in combination with statins.
Relationship of common variants in VEGFA gene with osteonecrosis of the femoral head: A Han Chinese population based association study
Authors: Ma Wenlong , Xin Kun , Chen Ke , Tang Hongtao , Chen Honggan , Zhi Liqiang , Liu Hongliang 
Published: October 2018

AbstractThe pathology of non-traumatic osteonecrosis of the femoral head (ONFH) is complex. Several studies have linked some polymorphisms of vascular endothelial growth factors A (VEGFA) with ONFH, but the results are not consistent and are even conflicting. In the study, 22 single nucleotide polymorphisms (SNPs) in VEGFA were genotyped in 1,762 subjects (489 cases and 1,273 controls). Genetic association analyses were performed in single markers and haplotype levels. Stratification analysis was conducted for ONFH patients. Gene by environment interactions were tested between VEGFA and the smoking status of the subjects. Gene expression and eQTL data of significant SNPs were extracted from GTEx to examine their potential biological function. The SNP, rs2010963, was identified to be significantly associated with ONFH (χ2 = 11.66, P = 0.0006, OR = 1.29). Haplotypes including rs2010963 were also identified to be correlated with ONFH in the haplotype-based analyses. After stratifying by the causes of ONFH, a significant signal from rs2010963 could only be identified in alcohol-induced patients (Pallelic = 0.0009) but not in steroid-induced patients (Pallelic = 0.055). No significant results were obtained from the gene by environmental interaction analyses. Significant expression differences of VEGFA were identified in multiple human tissues for different genotypes of rs2010963. Our findings indicate that SNP rs2010963 is significantly associated with ONFH.
DNA barcodes of Antipode marine invertebrates in Bay of Biscay and Gulf of Lion ports suggest new biofouling challenges
Authors: Miralles L. , Ardura A. , Clusa L. , Garcia-Vazquez E. 
Published: October 2018

AbstractMarine biological invasions threaten global biodiversity nowadays. In this article, we have studied fouling communities from 10 port areas of south Bay of Biscay (Atlantic Ocean) and Gulf of Lion (Mediterranean Sea). A total of 834 individuals were genetically barcoded and corresponded to 95 different species. A total of 76 native species 8 genera and 1 family were identified, 58 from the Bay of Biscay and 23 from the Gulf of Lion. Furthermore, 19 species were identified as non-indigenous or cryptogenic (18 from the Bay of Biscay and 4 from the Gulf of Lion). We found a high proportion of Antipode non-indigenous species (NIS) that represented the 19.3% of all sampled individuals and the 54.21% of NIS specimens of this study. A framework for inference of donor regions based on a phylogenetic screening of genetic sequences was proposed as a proof of concept and tested, as well as models for the relationship between NIS introductions, maritime imports and distance to NIS native range and inferred donor areas. Consistent generalized linear models (GLM) with positive association between NIS genetic diversity and distance, not with maritime growth weight imports, strongly suggest that distant NIS could pose higher invasion risk than closer species. Selection for wider tolerance ranges during the long travel –direct or stepwise, as well as environmental similarity between donor and receiving regions, may explain these results.
Experimental manipulation of monoamine levels alters personality in crickets
Authors: Abbey-Lee Robin N. , Uhrig Emily J. , Garnham Laura , Lundgren Kristoffer , Child Sarah , Løvlie Hanne 
Published: October 2018

AbstractAnimal personality has been described in a range of species with ecological and evolutionary consequences. Factors shaping and maintaining variation in personality are not fully understood, but monoaminergic systems are consistently linked to personality variation. We experimentally explored how personality was influenced by alterations in two key monoamine systems: dopamine and serotonin. This was done using ropinirole and fluoxetine, two common human pharmaceuticals. Using the Mediterranean field cricket (Gryllus bimaculatus), we focused on the personality traits activity, exploration, and aggression, with confirmed repeatability in our study. Dopamine manipulations explained little variation in the personality traits investigated, while serotonin manipulation reduced both activity and aggression. Due to limited previous research, we created a dose-response curve for ropinirole, ranging from concentrations measured in surface waters to human therapeutic doses. No ropinirole dose level strongly influenced cricket personality, suggesting our results did not come from a dose mismatch. Our results indicate that the serotonergic system explains more variation in personality than manipulations of the dopaminergic system. Additionally, they suggest that monoamine systems differ across taxa, and confirm the importance of the mode of action of pharmaceuticals in determining their effects on behaviour.