bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health science libraries in Sweden: new directions, expanding roles
Authors: Haglund Lotta , Roos Annikki , Wallgren‐Björk Petra 
Published: July 2018

AbstractLibrarians in Sweden are facing huge challenges in meeting the demands of their organisations and users. This article looks at four key areas: coping with open science/open access initiatives; increasing demands from researchers for support doing systematic reviews; understanding user experiences in Swedish health science libraries; and the consequences of expanding roles for recruitment and continuing professional development. With regard to changing roles, there is an increasing shift from the generalist towards the expert role. The authors raise the issue as to how to prepare those new to the profession to the changing environment of health science libraries.
Optimal search strategies for identifying moderators and predictors of treatment effects in PubMed
Authors: Tummers Marcia , van Hoorn Ralph , Levering Charlotte , Booth Andrew , van der Wilt Gert Jan , Kievit Wietske 
Published: July 2018

AbstractBackgroundTreatment effects differ across patients. To guide selection of treatments for patients, it is essential to acknowledge these differences and identify moderators or predictors. Our aim was to generate optimal search strategies (commonly known as filters) for PubMed to retrieve papers identifying moderators and predictors of treatment effects.MethodsSix journals were hand‐searched for articles on moderators or predictors. Selected articles were randomly allocated to a development and validation set. Search terms were extracted from the development set and tested for their performance. Search filters were created from combinations of these terms and tested in the validation set.ResultsOf 4407 articles, 198 were considered to be relevant. The most sensitive filter in the development set ‘(“Epidemiologic Methods” [MeSH] OR assign* OR control*[tiab] OR trial*[tiab]) AND therapy*[sh]’ yielded in the validation set a sensitivity of 89% [88%–90%] and a specificity of 80% [79%–82%].ConclusionsThe search filters created in this study can help to efficiently retrieve evidence on moderators and predictors of treatment effect. Testing of the filters in multiple domains should reveal robustness across disciplines. These filters can facilitate the retrieval of evidence on moderators and predictors of treatment effects, helping the implementation of stratified or personalised health care.
Morphology and tumour‐infiltrating lymphocytes in high‐stage, high‐grade serous ovarian carcinoma correlated with long‐term survival
Authors: Darb‐Esfahani Silvia , Kolaschinski Ivonne , Trillsch Fabian , Mahner Sven , Concin Nicole , Vergote Ignace , Van Nieuwenhuysen Els , Achimas‐Cadariu Patriciu , Glajzer Joanna , Woopen Hannah , Wienert Stefan , Taube Eliane T , Stanske Mandy , Kulbe Hagen , Denkert Carsten , Sehouli Jalid , Braicu Elena I 
Published: July 2018

AimsAdvanced‐stage ovarian high‐grade serous carcinoma (HGSC) is a poor‐prognosis cancer; however, a small and poorly characterised subset of patients shows long‐term survival. We aimed to establish a cohort of HGSC long‐term survivors for histopathological and molecular analysis.Methods and resultsParaffin blocks from 151 patients with primary FIGO III/IV HGSC and progression‐free survival (PFS) >5 years were collected within the Tumorbank Ovarian Cancer (TOC) Network; 77 HGSC with a PFS <3 years were used as a control group. A standardised analysis of histological type and morphological features was performed. Ki67 index, tumour‐infiltrating lymphocytes (TILs) and major histocompatibility complex expression (MHC1/2) were determined by immunohistochemistry. A total of 117 of 151 tumours (77.5%) in the long‐term survivor group fulfilled the World Health Organisation (WHO) criteria of HGSC after review, and of these, 83 patients (70.9%) fulfilled all clinical criteria for inclusion into our cohort. Tumours of long‐term survivors had significantly higher CD3+ and CD8+ TILs and were more frequently positive for MHC2 than controls (P = 0.004, P = 0.025, P = 0.048). However, there were also long‐term survivors (up to 20%) with low TILs or low MHC expression. TILs and MHC had no impact on survival in long‐term survivors. Morphological and Ki67 analysis revealed no differences between long‐term survivors and controls.ConclusionsHGSC from long‐term survivors have higher‐level T cell infiltration and antigen‐presentation capacity; however, this is not a prerequisite for an excellent prognosis. Histopathological criteria are not capable to identify these patients. Further extensive clinical and molecular characterisation of this enigmatic subgroup is ongoing to understand the reasons of long‐term survival in HGSC.
Prognostic value of histone H3 serine 10 phosphorylation and histone H4 lysine 12 acetylation in oral squamous cell carcinoma
Authors: Campos‐Fernández Esther , Matsuo Flavia S , Andrade Marília F , Servato João P S , Loyola Adriano M , Cardoso Sérgio V , Siva Sindeval J , Moraes Alberto da S , de Faria Paulo R 
Published: July 2018

AimsStudies on epigenetics in oral squamous cell carcinoma (OSCC) are rare. Histone modifications comprise epigenetic mechanisms that perform a key role in gene transcription and may regulate tumour development. Thus, the aim of this study was to determine whether two post‐translational histone modifications, i.e. phosphorylation of serine 10 in histone H3 and acetylation of lysine 12 in histone H4, have prognostic value for OSCC patients.Methods and resultsParaffin‐embedded tissue samples of 90 patients diagnosed with OSCC were obtained and subjected to immunohistochemical staining with antibodies against histone H3 with phosphorylation of serine 10 (H3S10ph) and histone H4 with acetylation of lysine 12 (H4K12ac). The associations of H3S10ph and H4K12ac expression levels with clinicopathological factors were determined. Five‐year survival analysis and univariate and multivariate analyses were also performed. Both H3S10ph and H4K12ac were expressed in the nuclei of tumour cells. A low median of H3S10ph expression was significantly associated with cervical lymph node metastasis. Tumours with high H4K12ac expression were significantly associated with gender, alcohol consumption, and cervical lymph node metastasis. H4K12ac was also shown to have independent prognostic value in the multivariate analysis. Tumours with high H3S10ph expression, size >40 mm, an advanced stage and the presence of cervical lymph node metastases were associated with a better 5‐year survival rate. Tumours with low H4K12ac expression, size >40 mm, an advanced stage and cervical lymph node metastasis were associated with a better 5‐year survival rate.ConclusionsThese findings suggest that H3S10ph, and mainly H4K12ac, may play a role in OSCC progression and the occurrence of cervical lymph node metastasis. Also, the expression level of H4K12ac could be an independent prognostic factor for OSCC patients.
A morphological and molecular study of proposed early forms of traditional serrated adenoma
Authors: Bettington Mark , Rosty Christophe , Whitehall Vicki , Leggett Barbara , McKeone Diane , Pearson Sally‐Ann , Walker Neal 
Published: July 2018

AimsTraditional serrated adenoma (TSA) is the least common subtype of serrated colorectal polyp. Large protuberant lesions are easily recognised; however, the origins of TSAs are not known, and early forms have not been described. Some large TSAs present with a flat ‘shoulder’ component surrounding the central protuberant component. We hypothesised that small polyps with the same histology as these shoulder regions may represent early TSAs. Thus the primary aim of the study is to describe the histology of these presumptive early TSAs.Methods and resultsWe collected 70 small (<10 mm) polyps that may represent early TSAs on the basis of typical TSA cytology covering the luminal surface. We also identified 12 large TSAs with a shoulder component resembling these small polyps. The study polyp patients had a mean age of 58 years, and 54% were female; the polyps had a mean diameter of 4.1 mm and were predominantly distal (71%). Morphologically, slit‐like serrations were present in 81%, ectopic crypt formations were present in 67%, and a villous component was present in 47%. These histological features were similar to those of the 12 shoulder lesions. Immunohistochemical stains showed an absence of β‐catenin nuclear expression in 96% of the small polyps, retained expression of MLH1 in 100%, and Ki67 positivity restricted to the crypt bases and ectopic crypt formations. BRAF and KRAS mutations were identified in 47% and 31% of the polyps, respectively. BRAF‐mutated polyps were more likely than KRAS‐mutated polyps to arise in a precursor polyp (82% versus 18%, P < 0.001), and were more likely to have slit‐like serrations (100% versus 73%, P = 0.003).ConclusionsThese morphological, immunohistochemical and molecular findings are similar to what has been reported in large TSAs, and support the hypothesis that these polyps represent early forms of TSA.
Effect of hot oven and microwave roasting on garden cress (Lepidium sativum) seed flour quality and fatty acid composition, thermal and dielectric properties of extracted oil
Authors: Mulla Mehrajfatema , Ahmed Jasim , Al‐Sharrah Tahani 
Published: July 2018

SummaryThe effect of roasting (microwave and oven) on functional properties of garden cress (GC) (Lepidium sativum) seed flour, oil yield and fatty acid composition, colour, melting and crystallisation of oil were investigated. The obtained results revealed that roasting significantly influenced the physicochemical properties of the flour, and doubled the oil yield. The GC oil was rich in α‐linolenic acid (31.05%) and oleic acid (22.1%) along with the presence of other fatty acids including linoleic acid, erucic, stearic and arachidic acid. No significant difference in MUFA content and the U/S fatty acid ratio of GC oil was observed due to roasting. The oil sample exhibited two distinct endothermic melting transitions (≈ −35 °C and −19 °C) and one crystallisation peak (≈ −54 °C), those peaks were unaffected by the roasting. These observations were confirmed by FTIR spectroscopy. Therefore, roasting pretreatment is a promising technique to improve GC oil yield while preserving oil quality.
Accurate light microscopic diagnosis of South‐East Asian ovalocytosis
Authors: Nixon Christian P. , Satyagraha Ari W. , Baird Grayson L. , Harahap Alida R. , Panggalo Lydia V. , Ekawati Lenny L. , Sutanto Inge , Syafruddin Din , Kevin Baird J. 
Published: July 2018

AbstractIntroductionSouth‐East Asian ovalocytosis (SAO) is a common inherited red blood cell polymorphism in South‐East Asian and Melanesian populations, coinciding with areas of malaria endemicity. Validation of light microscopy as a diagnostic alternative to molecular genotyping may allow for its cost‐effective use either prospectively or retrospectively by analysis of archived blood smears.MethodsWe assessed light microscopic diagnosis of SAO compared to standard PCR genotyping. Three trained microscopists each assessed the same 971 Giemsa‐stained thin blood films for which SAO genotypic confirmation was available by PCR. Generalized mixed modeling was used to estimate the sensitivity, specificity, positive predictive value, and negative predictive value of light microscopy vs “gold standard” PCR.ResultsAmong red cell morphologic parameters evaluated, knizocytes, rather than ovalocytic morphology, proved the strongest predictor of SAO status (odds ratio [OR] = 19.2; 95% confidence interval [95% CI] = 14.6‐25.3; P ≤ 0.0001). The diagnostic performance of a knizocyte‐centric microscopic approach was microscopist dependent: two microscopists applied this approach with a sensitivity of 0.89 and a specificity of 0.93. Inter‐rater reliability among the microscopists (κ = 0.20) as well as between gold standard and microscopist (κ = 0.36) underperformed due to misclassification of stomatocytes as knizocytes by one microscopist, but improved substantially when excluding the error‐prone reader (κ = 0.65 and 0.74, respectively).ConclusionLight microscopic diagnosis of SAO by knizocyte visual cue performed comparable to time‐consuming and costlier molecular methods, but requires specific training that includes successful differentiation of knizocytes from stomatocytes.
Insights into the ternary eutectic microstructure formed in intercolony regions in Al2O3–ZrO2(Y2O3) system
Authors: Fu Lian‐sheng , Chen Guo‐qing , Fu Xue‐song , Zhou Wen‐long 
Published: July 2018

AbstractAl2O3/ZrO2(Y2O3) pseudo‐binary eutectic melt may solidify in the dendritic form at the low G/v ratio (thermal gradient G divided by growth rate v) associated with the Y2O3 microsegregation along the monovariant line. Especially, in the system with high Y2O3 content (≥4.5 mol%), an Al2O3/ZrO2/YAG ternary eutectic in situ microstructure growing with a “plane front” will appear at the boundaries of dendritic structures. The volume fraction of the ternary eutectic increases with the increase in Y2O3 content. It was found that the amount of ternary eutectic can be well predicted by the Scheil equation (or nonequilibrium lever rule).
A male's seminal fluid increases later competitors’ productivity
Authors: Nguyen Trinh T. X. , Moehring Amanda J. 
Published: July 2018

AbstractPolyandrous females allow for sexual selection to persist after mating. In the event that females successfully mate with more than one male, sperm competition can occur. Seminal fluid proteins can indirectly affect a male's success in sperm competition through reducing the remating behaviour of females and can directly influence sperm competition through directly displacing competitor sperm or inducing females to eject it. These direct effects on competitor sperm are thought to contribute to the ‘second male advantage’, whereby the second male to mate sires the majority of offspring. Here, we show an additional mechanism where seminal proteins already present within a mated female appear to enhance offspring production of later competitor males, and contribute to second male advantage. Counter to expectation, increased offspring production was not due to a priming effect of greater early female productivity, nor was it through a general and consistent increase in offspring production. Instead, enhanced productivity was solely through lengthening the time that offspring are sired by the second male, indicating that seminal proteins from the first male to mate may enhance second male advantage through a presumably unintended protective effect on subsequent competitor sperm.
Negative regulation of resistance protein‐mediated immunity by master transcription factors SARD1 and CBP60g
Authors: Sun Tongjun , Liang Wanwan , Zhang Yuelin , Li Xin 
Published: July 2018

SummarySalicylic acid (SA) is an essential defence hormone in plants. Upon pathogen infection, induced biosynthesis of SA is mediated by Isochorismate synthase 1 (ICS1), whose gene transcription is controlled mainly through two redundant transcription factors, SAR Deficient 1 (SARD1) and Calmodulin‐binding protein 60‐like g (CBP60g). Although these master transcription factors regulate not only positive, but also negative regulators of immunity, how they control signaling events downstream of different immune receptors is unclear. Using autoimmune mutants activating immunity mediated by different receptors we show that, although the sard1 cbp60g double mutant almost fully suppresses the activation of defence mediated by suppressor of npr1‐1, constitutive 2 (snc2), it strikingly enhances snc1, which carries a gain‐of‐function mutation in an intracellular nucleotide‐binding leucine‐rich repeat (NLR) immune receptor. This negative regulation of immunity is achieved through the transcriptional regulation of negative regulators, such as Nudix hydrolase homolog 6 (NUDT6). Our study highlights the diverse roles, especially the negative ones, in the regulation of plant immunity by the two master immune transcription factors SARD1 and CBP60g.
Patient Safety Culture Associated With Patient Safety Competencies Among Registered Nurses
Authors: Cho Seon Mi , Choi JiSun 
Published: July 2018

AbstractPurposeTo investigate the relationships between registered nurses’ (RNs’) perceptions of the culture of patient safety in their workplace and their patient safety competency—attitudes, skills, and knowledge.DesignA cross‐sectional study design was used. Data were collected by using a self‐reported survey from 343 RNs working in a university hospital in Seoul, South Korea.MethodsPatient safety culture was measured using the Korean version of the Agency for Healthcare Research and Quality's Hospital Survey on Patient Safety Culture (Hospital SOPSTM). Patient safety competency was measured using the Patient Safety Competency Self‐Evaluation tool. Multiple regression analysis was performed using Stata version 14 to examine the relationships between patient safety culture and RNs’ patient safety competency, while adjusting for the RNs nested in their units.FindingsOf the 10 specific aspects of patient safety culture, only teamwork within units was significantly related to overall safety competency. In relation to each of the three patient safety competencies, teamwork within and across units and supervisor or manager expectations were significantly related to attitudes, while teamwork within units and learning were significantly related to skills. Only organizational learning was significantly related to knowledge.ConclusionsAlthough teamwork, leadership, and continuous learning in the nursing unit were major factors influencing RNs’ safety competency, the relationships of these factors to patient safety attitudes, skills, and knowledge among RNs were varied.Clinical RelevanceCreating a unit‐specific patient safety culture that is tailored to the competencies of the unit's RNs in patient safety practice would be essential to enhance and maintain high levels of patient safety attitudes, skills, and knowledge among the unit's RNs, which would ultimately affect patient safety.
Severe vision loss caused by cosmetic filler augmentation: Case series with review of cause and therapy
Authors: Thanasarnaksorn Wilai , Cotofana Sebastian , Rudolph Christina , Kraisak Patcharahatai , Chanasumon Nongsak , Suwanchinda Atchima 
Published: July 2018

SummaryHyaluronic acid (HA) injection is a popular nonsurgical, facial rejuvenating procedure. Due to the rapidly expanding use of HA injections, significant potential complications have also increased in frequency. Among these complications, the rare but most devastating one is arterial occlusion, which can result in skin necrosis or blindness. To describe the mechanisms behind vision loss secondary to hyaluronic acid injection and the efficacy of treatments to restore vision and associated ocular functionality. We reviewed six cases of patients from October 2011 to December 2017 who experienced vision loss after receiving facial HA injections and the subsequent treatments undertaken to attempt to reverse the vision loss and additional eye complications. Of the six patients, four received nose, one received forehead, and another one received temple injections. All six patients developed vision loss secondary to hyaluronic acid embolization in retinal or ophthalmic arteries. Additional complications included severe periorbital pain, ptosis, impairment of extraocular muscle functionality. Recovery of vision was dependent on the type, frequency, and duration of subsequent treatment. Vision loss is a rare but catastrophic complication caused by hyaluronic injection that occurs secondary to hyaluronic acid embolization in retinal or ophthalmic arteries due to retrograde flow from facial vascular anastomoses. We suggest the early supratrochlear/supraorbital hyaluronidase injection, ocular massage, and re‐breathing into a plastic bag as safe, uncomplicated and effective methods to restore the retinal circulation and reverse vision loss.
Let’s Talk about Language: A Review of Language‐Sensitive Research in International Management
Authors: Karhunen Päivi , Kankaanranta Anne , Louhiala‐Salminen Leena , Piekkari Rebecca 
Published: July 2018

AbstractThis paper explores the assumptions underlying the core concept of language used in the growing field of language‐sensitive research in international management. We reviewed 92 articles on the topic of language(s) in multinational corporations published during the period 1997‐2015, and applied a linguistic lens to uncover how these articles ‘talk about language’. The assumptions found in these articles can be grouped into three complementary categories that take a structural, functional or social practice view of language. We go beyond the review by also reflecting on the consequences that these underlying assumptions have for the study of language in multinationals. We consider the social practice view the most promising one, and propose a future research agenda for advancing it and thereby contributing to theorizing about the multinational corporation more broadly.
Stock Return or Sales Growth? Multiple Performance Feedback and Strategic Investments Under Securities Analysts’ Earnings Pressure
Authors: Zhang Yu , Gong Yan 
Published: July 2018

AbstractPressure to meet or beat earnings forecasts from securities analysts leads managers of publicly traded firms to improve short‐term earnings by cutting strategic investments at the expense of long‐term competitiveness. Drawing on the behavioral theory of the firm, we explore how different dimensions of performance feedback moderate managerial responses to this pressure. We find that the negative impact of earnings pressure on a firm’s strategic investments is strengthened when it receives performance feedback from lower stock returns but is weakened when the firm receives performance feedback from lower sales growth. When both dimensions of performance feedback are present, we find that sales growth has a stronger moderating effect. Our paper contributes to the developing literature on multiple dimensions of performance feedback by demonstrating how stock price and sales growth differentially influence managerial responses to earnings pressure. From a management standpoint, we highlight the possibility that performance feedback influences managerial responses to earnings pressures in ways that managers may not fully consider.
Growing Followers: Exploring the Effects of Leader Humility on Follower Self‐Expansion, Self‐Efficacy, and Performance
Authors: Mao Jianghua , Chiu Chia‐Yen (Chad) , Owens Bradley P. , Brown Jacob A. , Liao Jianqiao 
Published: July 2018

AbstractAlthough the effectiveness of leader humility has been well documented, our understanding of how leader humility influences followers psychologically is limited. Surpassing a mere leader‐centric understanding of the leader influence process by more fully understanding how leadership behavior shapes followers psychologically has been identified as a critical need by leadership scholars. Drawing on self‐expansion theory, we argue that leader humility triggers followers’ self‐expansion and that this psychological change enhances followers’ self‐efficacy, which in turn contributes to followers’ task performance. We also argue that the relationship between leader humility and followers’ self‐expansion is strengthened when leaders and followers are similar in age and gender. Using a time‐lagged research design with responses from 256 leader–follower dyads, we found support for our proposed model. We discuss the theoretical implications for our findings and suggest areas for future research.