bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of vegetation encroachment by natural and induced channel avulsions: A physical model
Authors: Javernick Luke , Bertoldi Walter 
Published: August 2019

AbstractFlow regulation and water abstractions may change the complex relationship between river hydraulics, morphology, and riparian vegetation. As a result, rivers are likely to decrease their dynamics, increase the amount of vegetation, and modify their habitat structure. Flood events provide a natural mechanism for removal of invasive vegetation and recreation of natural floodplain habitats. This work aims at evaluating and quantifying how gravel‐bed braided rivers naturally control vegetation encroachment through morphological processes and the impact of both naturally occurring and induced avulsions. Flume experiments were conducted in a 24‐m‐long x 1.6‐m‐wide channel filled with well‐sorted sand and constant longitudinal gradient at 0.01 m/m. Once a braided network developed, the flume was seeded with Eruca sativa at a density of 1.5 seeds/cm2 and grown until an approximate height of 1.1 cm. Experiments evaluated low‐, medium‐, and large‐flood events and documented morphological changes and impacts to vegetation at four intervals during the experiments. High‐resolution images captured approximately 3 m above the flume were used to produce accurate Structure‐from‐Motion‐derived topography and orthoimagery (average errors 2 mm). Vegetation dynamics were observed to be highly variable and depend on local morphological changes and bank erosion. Discharge is the first‐order control on vegetation removal, but our results show that occurrence of avulsions significantly increases vegetation removal. The experiments highlight that a relatively small amount of sediment relocation can be an effective tool to induce avulsions and reduce vegetation encroachment on regulated rivers.
Associations between subjective time perception and well‐being during stressful waiting periods
Authors: Rankin Kyla , Sweeny Kate , Xu Sandra 
Published: August 2019

AbstractThe passage of time is a subjective experience and can be easily distorted by concurrent emotions. Specifically, time seems to move particularly slowly when people are in a negative emotional state. The aim of the current studies was to evaluate the bidirectional relationship between subjective time perception and distress during stressful waiting periods, during which the slow passage of time may be particularly distressing. Across studies of undergraduate students awaiting a midterm exam grade (Study 1) and law graduates awaiting bar exam results (Studies 2 and 3), results revealed consistent links between distress and time perception across the waiting periods, with tentative evidence for bidirectional relationships between these experiences. That is, people who perceived time as moving slowly while they waited tended to report greater distress across the waiting period (particularly worry, anxiety, negative emotion, and poor coping), and people who reported greater distress tended to perceive time as moving more slowly. The links between distress and time perception suggest the possibility of downward spirals during stressful waiting periods, such that distress makes time seem to slow down, which then exacerbates distress. We discuss avenues for future research and potential remedies to derail the spiral of distress and time perception.
Trade study to select best alternative for cable and pulley simulation for cranes on offshore vessels
Authors: Fotland Gaute , Haskins Cecilia , Rølvåg Terje 
Published: August 2019

AbstractCranes on offshore vessels are subjected to crane dynamics, structural couplings to the vessel, and environmental influence by waves and currents. The recent trend has been to use larger cranes on smaller vessels, which makes the lifting operation more complex and potentially dangerous. The use of digital twins (DTs) is emerging as one way to enable safer operations, real‐time simulation, and maintenance prediction. On offshore vessels, a DT can monitor the lifting operation to create a safer work environment. The SPADE (stakeholders, problem formulation, alternatives, decision making, and evaluation) model has been used as a framework toward the creation of a DT of cranes on offshore vessels. Several cases involving simulation of cranes revealed the lack of an adequate simulation of cable and pulleys suitable for use in a DT. The simulation is important for accurate results and for implementation in control systems. A trade study was performed to determine a numerical method adequate for cable and pulley simulation. The trade study identified the absolute nodal coordinate formulation in the framework of arbitrary Lagrangian–Eulerian as a promising numerical formulation.
Longitudinal analysis of risk factors for dementia based on Mild Cognitive Impairment Screen results and questionnaire responses from healthy Japanese individuals registered in an online database
Authors: Ogawa Masayo , Maruo Kazushi , Sone Daichi , Shimada Hiroyuki , Suzuki Keisuke , Watanabe Hiroshi , Matsuda Hiroshi , Mizusawa Hidehiro 
Published: August 2019

AbstractIntroductionDespite an urgent need for developing remedial measures against dementia, no disease‐modifying drugs have been developed. Efficient protocols for participant recruitment need to be established for conducting clinical trials. To meet this need, a large‐scale online registry system, the Integrated Registry of Orange Plan (IROOP®), was created for healthy individuals. Although the risk factors for dementia have been discussed in our previous studies for a short interval of 6 months, some factors remain controversial. The present study aimed to explore factors affecting longitudinal changes in cognitive function for a longer interval of 18 months using the IROOP® data.MethodsThis study assessed the longitudinal changes in the collated data for predicting the risk of dementia and included 473 individuals (175 men and 298 women; mean age 59.6 ± 10.1 years) registered in the IROOP® between July 5, 2016 and January 15, 2018 who completed the initial questionnaire and brief assessment of cognitive function (Mild Cognitive Impairment Screen) at baseline and the regular questionnaire and the Mild Cognitive Impairment Screen at least once after baseline. Statistical analyses were performed using IBM SPSS, version 23.0, for Windows for demographic data and the MIXED procedure in SAS, version 9.4, for the linear mixed‐effect model. In each analysis, the statistical significance level was set at P < .05.ResultsMood, sleep, quality of life, and medical histories including cognition were found to influence longitudinal changes in cognitive function.DiscussionGiven the multifactorial etiology of dementia, preventive measures targeting multiple domains are required for maintaining cognitive function, instead of focusing on one lifestyle factor.
Trajectories and Predictors of Children's Early-Starting Conduct Problems: Child, Family, Genetic, and Intervention Effects
Authors: Shaw Daniel S. , Galán Chardée A. , Lemery-Chalfant Kathryn , Dishion Thomas J. , Elam Kit K. , Wilson Melvin N. , Gardner Frances 
Published: August 2019

AbstractSeveral research teams have previously traced patterns of emerging conduct problems (CP) from early or middle childhood. The current study expands on this previous literature by using a genetically-informed, experimental, and long-term longitudinal design to examine trajectories of early-emerging conduct problems and early childhood discriminators of such patterns from the toddler period to adolescence. The sample represents a cohort of 731 toddlers and diverse families recruited based on socioeconomic, child, and family risk, varying in urbanicity and assessed on nine occasions between ages 2 and 14. In addition to examining child, family, and community level discriminators of patterns of emerging conduct problems, we were able to account for genetic susceptibility using polygenic scores and the study's experimental design to determine whether random assignment to the Family Check-Up (FCU) discriminated trajectory groups. In addition, in accord with differential susceptibility theory, we tested whether the effects of the FCU were stronger for those children with higher genetic susceptibility. Results augmented previous findings documenting the influence of child (inhibitory control [IC], gender) and family (harsh parenting, parental depression, and educational attainment) risk. In addition, children in the FCU were overrepresented in the persistent low versus persistent high CP group, but such direct effects were qualified by an interaction between the intervention and genetic susceptibility that was consistent with differential susceptibility. Implications are discussed for early identification and specifically, prevention efforts addressing early child and family risk.
Co-occurring change in children's conduct problems and maternal depression: Latent class individual participant data meta-analysis of the Incredible Years parenting program
Authors: Leijten Patty , Gardner Frances , Melendez-Torres G.J. , Weeland Joyce , Hutchings Judy , Landau Sabine , McGilloway Sinéad , Overbeek Geertjan , van Aar Jolien , Menting Ankie , Orobio de Castro Bram , Berry Vashti , Gaspar Maria Filomena , Axberg Ulf , Mørch Willy-Tore , Scott Stephen 
Published: August 2019

AbstractChildren vary in the extent to which they benefit from parenting programs for conduct problems. How does parental mental health change if children benefit less or more? We assessed whether changes in conduct problems and maternal depressive symptoms co-occur following participation in the Incredible Years parenting program. We integrated individual participant data from 10 randomized trials (N= 1280; children aged 2–10 years) and distinguished latent classes based on families' baseline and post-test conduct problems and maternal depressive symptoms, using repeated measures latent class analysis (RMLCA) and latent transition analysis (LTA). Classes differed mainly in severity of conduct problems and depression (RMLCA; 4 classes). Conduct problems reduced in all classes. Depressive symptoms did not change in most classes, except in a class of families where conduct problems and depression were particularly severe. Incredible Years led to a greater likelihood of families with particularly severe conduct problems and depression moving to a class with mild problems (LTA; 3 classes). Our findings suggest that for the majority of families, children's conduct problems reduce, but maternal depressive symptoms do not, suggesting relative independence, with the exception of families with severe depression and severe conduct problems where changes for the better do co-occur.
Future Climate and Land Use Change Impacts on River Flows in the Tapajós Basin in the Brazilian Amazon
Authors: Farinosi Fabio , Arias Mauricio E. , Lee Eunjee , Longo Marcos , Pereira Fabio F. , Livino Angela , Moorcroft Paul R. , Briscoe John 
Published: August 2019

AbstractLand conversion and changing climate are expected to significantly alter tropical forest hydrology. We used a land surface model integrated with a river routing scheme to analyze the hydrological alterations expected in the Tapajós River basin, a large portion of the Brazilian Amazon, caused by two environmental drivers: climate and land use. The model was forced with two future climate scenarios (years 2026–2045) from the Earth System Model HadGem2‐ES with moderate (+4.5 W/m2 radiative forcing value in the year 2100 with respect to preindustrial levels) and severe (+8.5 W/m2) representative atmospheric carbon dioxide pathways (Representative Concentration Pathways). We tested the sensitivity of our results to the uncertainty in future climate projections by running simulations with IPSL‐CM5 (wettest scenarios) and GISS‐E2 (driest scenarios). Human land use effects on vegetation were evaluated using a limited and an extreme deforestation scenario. Our analysis indicates that climate change is predicted to reduce river flows across seasons (up to 20%) and bring a considerable shift in flow seasonality toward a later onset (nearly 1.5 months) and increase in interannual variability. While land use change partially counteracts the climate‐driven diminishing trend in river flows, it is expected to contribute to a further increase in interannual and intraannual variability. From a water management perspective, the overall reduction of river flows and their increased variability, combined with the shift and the shortening of the wet season, could potentially affect the productivity of the large hydropower systems planned for the region and the growing demand for agricultural and transport expansion.
Biomarkers for response in major depression: comparing paroxetine and venlafaxine from two randomised placebo-controlled clinical studies
Authors: Carboni Lucia , McCarthy Dennis J. , Delafont Bruno , Filosi Michele , Ivanchenko Elena , Ratti Emiliangelo , Learned Susan M. , Alexander Robert , Domenici Enrico 
Published: August 2019

AbstractThe identification of biomarkers of response might speed drug development and set the premises to assist clinical practice in psychiatry. In this work, we evaluated a panel of peripheral biomarkers (including IL-6, IL-10, TNF-α, TNFRII, BDNF, CRP, MMP9 and PAI1) in depressed patients receiving paroxetine, venlafaxine, or placebo. Samples were obtained from two randomised placebo-controlled studies evaluating the efficacy and tolerability of a novel drug candidate, using either paroxetine or venlafaxine as active comparators. In both studies, the biomarker candidates were analysed in plasma collected at randomization and after 10 weeks of treatment with either placebo or active comparator (for a total of 106 and 108 subjects in the paroxetine and venlafaxine study, respectively). Data were obtained by multiplexing sandwich-ELISA system. Data were subjected to statistical analysis to assess their correlation with baseline severity and with response outcome. Increases in biomarker levels were correlated with reduction in depression severity for TNF-α, IL-6 IL-10 and CRP. Response to paroxetine treatment correlated with baseline IL-10, IL-6 and TNF-α levels, with the strongest signal being observed in males. In the venlafaxine study, a correlation was observed only between CRP level at randomisation and response, suggesting differences between the two active treatments and the two studies. Our investigations suggest that a combination of pro- and anti-inflammatory cytokines may predict response outcome in patients treated with paroxetine. The potential for IL-10, IL-6 and TNF-α as response biomarkers for a wider range of antidepressants warrants further investigations in clinical trials with other monoamine reuptake inhibitors.
Clinical and genetic characteristics of 14 patients from 13 Japanese families with RPGR-associated retinal disorder: report of eight novel variants
Authors: Mawatari Go , Fujinami Kaoru , Liu Xiao , Yang Lizhu , Yokokawa Yu-Fujinami , Komori Shiori , Ueno Shinji , Terasaki Hiroko , Katagiri Satoshi , Hayashi Takaaki , Kuniyoshi Kazuki , Miyake Yozo , Tsunoda Kazushige , Yoshitake Kazutoshi , Iwata Takeshi , Nao-i Nobuhisa ,   on behalf of the JEGC study group
Published: August 2019

AbstractVariants in the retinitis pigmentosa GTPase regulator (RPGR) gene are a major cause of X-linked inherited retinal disorder (IRD). We herein describe the clinical and genetic features of 14 patients from 13 Japanese families harboring RPGR variants in a nationwide cohort. Comprehensive ophthalmological examinations were performed to classify the patients into one of the phenotype subgroups: retinitis pigmentosa (RP) and cone rod dystrophy (CORD). The mean age of onset/at examination was 13.8/38.1 years (range, 0–50/11–72), respectively. The mean visual acuity in the right/left eye was 0.43/0.43 (range, 0.1–1.7/−0.08–1.52) LogMAR unit. Eight patients had RP, and six had CORD. Whole-exome sequencing with target analyses identified 13 RPGR variants in 730 families with IRD, including 8 novel variants. An association between the phenotype subgroup and the position of variants (cutoff of amino acid 950) was revealed. To conclude, the clinical and genetic spectrum of RPGR-associated retinal disorder was first illustrated in a Japanese population, with a high proportion of novel variants. These results suggest the distinct genetic background of RPGR in the Japanese population, in which the genotype–phenotype association was affirmed. This evidence should be helpful monitoring and counseling patients and in selecting patients for future therapeutic trials.
Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression
Authors: Bae Joonbeom , Choi Sang-Pil , Isono Kyoichi , Lee Ji Yoon , Park Si-Won , Choi Chang-Yong , Han Jihye , Kim Sang-Hoon , Lee Han-Hyoung , Park Kyungmin , Jin Hyun Yong , Lee Suk Jun , Park Chung-Gyu , Koseki Haruhiko , Lee Young Sik , Chun Taehoon 
Published: August 2019

AbstractThe timely mobilization of hematopoietic stem and progenitor cells (HSPCs) is essential for maintaining hematopoietic and tissue leukocyte homeostasis. Understanding how HSPCs migrate between bone marrow (BM) and peripheral tissues is of great significance in the clinical setting, where therapeutic strategies for modulating their migration capacity determine the clinical outcome. Here, we identify an epigenetic regulator, Phc2, as a critical modulator of HSPC trafficking. The genetic ablation ofPhc2in mice causes a severe defect in HSPC mobilization through the derepression ofVcam1in bone marrow stromal cells (BMSCs), ultimately leading to a systemic immunodeficiency. Moreover, the pharmacological inhibition of VCAM-1 inPhc2-deficient mice reverses the symptoms. We further determine that Phc2-dependentVcam1repression in BMSCs is mediated by the epigenetic regulation of H3K27me3 and H2AK119ub. Together, our data demonstrate a cell-extrinsic role for Phc2 in controlling the mobilization of HSPCs by finely tuning their bone marrow niche.
Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
Authors: Hendus-Altenburger Ruth , Wang Xinru , Sjøgaard-Frich Lise M. , Pedraz-Cuesta Elena , Sheftic Sarah R. , Bendsøe Anne H. , Page Rebecca , Kragelund Birthe B. , Pedersen Stine F. , Peti Wolfgang 
Published: August 2019

AbstractVery little is known about how Ser/Thr protein phosphatases specifically recruit and dephosphorylate substrates. Here, we identify how the Na+/H+-exchanger 1 (NHE1), a key regulator of cellular pH homeostasis, is regulated by the Ser/Thr phosphatase calcineurin (CN). NHE1 activity is increased by phosphorylation of NHE1 residue T779, which is specifically dephosphorylated by CN. While it is known that Ser/Thr protein phosphatases prefer pThr over pSer, we show that this preference is not key to this exquisite CN selectivity. Rather a combination of molecular mechanisms, including recognition motifs, dynamic charge-charge interactions and a substrate interaction pocket lead to selective dephosphorylation of pT779. Our data identify T779 as a site regulating NHE1-mediated cellular acid extrusion and provides a molecular understanding of NHE1 substrate selection by CN, specifically, and how phosphatases recruit specific substrates, generally.
Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription
Authors: Zhu Yongchuan , Huang Min , Bushong Eric , Phan Sebastien , Uytiepo Marco , Beutter Elizabeth , Boemer Daniel , Tsui Kristin , Ellisman Mark , Maximov Anton 
Published: August 2019

AbstractThe formation of new memories requires transcription. However, the mechanisms that limit signaling of relevant gene programs in space and time for precision of information coding remain poorly understood. We found that, during learning, the cellular patterns of expression of early response genes (ERGs) are regulated by class IIa HDACs 4 and 5, transcriptional repressors that transiently enter neuronal nuclei from cytoplasm after sensory input. Mice lacking these repressors in the forebrain have abnormally broad experience-dependent expression of ERGs, altered synaptic architecture and function, elevated anxiety, and severely impaired memory. By acutely manipulating the nuclear activity of class IIa HDACs in behaving animals using a chemical-genetic technique, we further demonstrate that rapid induction of transcriptional programs is critical for memory acquisition but these programs may become dispensable when a stable memory is formed. These results provide new insights into the molecular basis of memory storage.
PAWH1 and PAWH2 are plant-specific components of an Arabidopsis endoplasmic reticulum-associated degradation complex
Authors: Lin Liangguang , Zhang Congcong , Chen Yongwu , Wang Yi , Wang Dinghe , Liu Xiaolei , Wang Muyang , Mao Juan , Zhang Jianjun , Xing Weiman , Liu Linchuan , Li Jianming 
Published: August 2019

AbstractEndoplasmic reticulum-associated degradation (ERAD) is a unique mechanism to degrade misfolded proteins via complexes containing several highly-conserved ER-anchored ubiquitin ligases such as HMG-CoA reductase degradation1 (Hrd1). Arabidopsis has a similar Hrd1-containing ERAD machinery; however, our knowledge of this complex is limited. Here we report two closely-related Arabidopsis proteins, Protein Associated With Hrd1-1 (PAWH1) and PAWH2, which share a conserved domain with yeast Altered Inheritance of Mitochondria24. PAWH1 and PAWH2 localize to the ER membrane and associate with Hrd1 via EMS-mutagenized Bri1 Suppressor7 (EBS7), a plant-specific component of the Hrd1 complex. Simultaneously elimination of two PAWHs constitutively activates the unfolded protein response and compromises stress tolerance. Importantly, the pawh1 pawh2 double mutation reduces the protein abundance of EBS7 and Hrd1 and inhibits degradation of several ERAD substrates. Our study not only discovers additional plant-specific components of the Arabidopsis Hrd1 complex but also reveals a distinct mechanism for regulating the Hrd1 stability.
Topological Lifshitz transitions and Fermi arc manipulation in Weyl semimetal NbAs
Authors: Yang H. F. , Yang L. X. , Liu Z. K. , Sun Y. , Chen C. , Peng H. , Schmidt M. , Prabhakaran D. , Bernevig B. A. , Felser C. , Yan B. H. , Chen Y. L. 
Published: August 2019

AbstractSurface Fermi arcs (SFAs), the unique open Fermi-surfaces (FSs) discovered recently in topological Weyl semimetals (TWSs), are unlike closed FSs in conventional materials and can give rise to many exotic phenomena, such as anomalous SFA-mediated quantum oscillations, chiral magnetic effects, three-dimensional quantum Hall effect, non-local voltage generation and anomalous electromagnetic wave transmission. Here, by using in-situ surface decoration, we demonstrate successful manipulation of the shape, size and even the connections of SFAs in a model TWS, NbAs, and observe their evolution that leads to an unusual topological Lifshitz transition not caused by the change of the carrier concentration. The phase transition teleports the SFAs between different parts of the surface Brillouin zone. Despite the dramatic surface evolution, the existence of SFAs is robust and each SFA remains tied to a pair of Weyl points of opposite chirality, as dictated by the bulk topology.