bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Concomitant Cartilage Lesions on Patient-Reported Outcomes After Anterior Cruciate Ligament Reconstruction: A Nationwide Cohort Study From Norway and Sweden of 8470 Patients With 5-Year Follow-up
Authors: Ulstein Svend , Årøen Asbjørn , Engebretsen Lars , Forssblad Magnus , Lygre Stein Håkon Låstad , Røtterud Jan Harald 
Published: July 2018

Background: The effect of concomitant focal cartilage lesions on patient-reported outcomes after anterior cruciate ligament reconstruction (ACLR) remains to be determined. Purpose: To evaluate the effect of concomitant partial-thickness (International Cartilage Repair Society [ICRS] grades 1-2) and full-thickness (ICRS grades 3-4) cartilage lesions on patient-reported outcomes 5 years after ACLR. Study Design: Cohort study; Level of evidence, 2. Methods: All patients who underwent unilateral primary ACLR registered in the Norwegian and Swedish National Knee Ligament Registries from 2005 to 2008 (n = 15,783) were included in the study. At 5-year follow-up, 8470 (54%) patients completed the Knee injury and Osteoarthritis Outcome Score (KOOS). Multivariable linear regression models were used to estimate the effect of concomitant partial-thickness and full-thickness cartilage lesions on patient-reported outcomes (KOOS) 5 years after ACLR. Results: Compared with no concomitant cartilage lesions, both partial-thickness and full-thickness cartilage lesions were indicators of statistically significant adverse effects on the KOOS in the adjusted regression analysis at 5-year follow-up after ACLR. Conclusion: ACL-injured patients with concomitant cartilage lesions reported worse outcomes and less improvement than those without cartilage lesions 5 years after ACLR.
Tackling obesity in mental health secure units: a mixed method synthesis of available evidence
Authors: Johnson Maxine , Day Matthew , Moholkar Rajesh , Gilluley Paul , Goyder Elizabeth 
Published: July 2018

BackgroundThe prevalence and incidence of obesity are high in people with severe mental illness (SMI). In England, around 6000 people with SMI access care from secure mental health units. There is currently no specific guidance on how to reduce the risk of obesity-related morbidity and mortality in this population.AimsTo identify international evidence that addresses the issue of obesity in mental health secure units.MethodA mixed method review of evidence (published 2000–2015) was carried out to assess obesity prevalence, intervention and policy change, as well as barriers to change.ResultsEvidence from 22 mainly small, non-comparator studies (reported in 21 papers) using a range of methods was reviewed. Dietary, physical activity and cultural interventions being implemented within secure units to address the problem of obesity showed some promising outcomes for physical health and health education. These were facilitated by adequate organisational resources, staff training and motivated staff. Holistic interventions that included a social and/or competitive element were more likely to be taken up. Involving patients in decision-making mediated the tension between facilitating behaviour change and imposing control. Barriers to successful outcomes included patient movement in and out of units, severity of mental health condition and resistance to change by patients and staff.ConclusionsDespite the promising outcomes reported, further assessment is needed of the feasibility, acceptability and effectiveness of interventions and policies targeting the obesogenic environment, using robust research methods.Declaration of interestNone.
Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate Cancer
Authors: Liu Deli , Takhar Mandeep , Alshalalfa Mohammed , Erho Nicholas , Shoag Jonathan , Jenkins Robert B. , Karnes R. Jeffrey , Ross Ashley E. , Schaeffer Edward M. , Rubin Mark A. , Trock Bruce , Klein Eric A. , Den Robert B. , Tomlins Scott A. , Spratt Daniel E. , Davicioni Elai , Sboner Andrea , Barbieri Christopher E. 
Published: July 2018

Purpose Molecular characterization of prostate cancer, including The Cancer Genome Atlas, has revealed distinct subtypes with underlying genomic alterations. One of these core subtypes, SPOP (speckle-type POZ protein) mutant prostate cancer, has previously only been identifiable via DNA sequencing, which has made the impact on prognosis and routinely used risk stratification parameters unclear. Methods We have developed a novel gene expression signature, classifier (Subclass Predictor Based on Transcriptional Data), and decision tree to predict the SPOP mutant subclass from RNA gene expression data and classify common prostate cancer molecular subtypes. We then validated and further interrogated the association of prostate cancer molecular subtypes with pathologic and clinical outcomes in retrospective and prospective cohorts of 8,158 patients. Results The subclass predictor based on transcriptional data model showed high sensitivity and specificity in multiple cohorts across both RNA sequencing and microarray gene expression platforms. We predicted approximately 8% to 9% of cases to be SPOP mutant from both retrospective and prospective cohorts. We found that the SPOP mutant subclass was associated with lower frequency of positive margins, extraprostatic extension, and seminal vesicle invasion at prostatectomy; however, SPOP mutant cancers were associated with higher pretreatment serum prostate-specific antigen (PSA). The association between SPOP mutant status and higher PSA level was validated in three independent cohorts. Despite high pretreatment PSA, the SPOP mutant subtype was associated with a favorable prognosis with improved metastasis-free survival, particularly in patients with high-risk preoperative PSA levels. Conclusion Using a novel gene expression model and a decision tree algorithm to define prostate cancer molecular subclasses, we found that the SPOP mutant subclass is associated with higher preoperative PSA, less adverse pathologic features, and favorable prognosis. These findings suggest a paradigm in which the interpretation of common risk stratification parameters, particularly PSA, may be influenced by the underlying molecular subtype of prostate cancer.
Lin28a overexpression reveals the role of Erk signaling in articular cartilage development
Authors: Kobayashi Tatsuya , Kozlova Anastasia 
Published: July 2018

ABSTRACT
Adult articular cartilage shows limited tissue turnover, and therefore development of the proper structure of articular cartilage is crucial for life-long joint function. However, the mechanism by which the articular cartilage structure is developmentally regulated is poorly understood. In this study, we show evidence that activation of extracellular signal-regulated kinases (Erk1/2) in articular chondrocyte progenitors during developmental stages control articular cartilage thickness. We found that overexpression of Lin28a, an RNA-binding protein that regulates organismal growth and metabolism, in articular chondrocyte progenitor cells upregulated Erk signaling and increased articular cartilage thickness. Overexpression of a constitutively active Kras mimicked Lin28a overexpression, and inhibition of Erk signaling during embryonic stages normalized the cartilage phenotype of both Kras- and Lin28a-overexpressing mice. These results suggest that articular cartilage thickness is mainly determined during the process of embryonic synovial joint development, which is positively regulated by Erk signaling.
Two-Sided Investment and Matching with Multidimensional Cost Types and Attributes
Authors: Dizdar Deniz 
Published: July 2018

Heterogeneous buyers and sellers must make investments before entering a continuum assignment market. I show that efficient ex post contracting equilibria (Cole, Mailath, and Postlewaite 2001b) exist in a general assignment game framework. I then shed light on what enables and what precludes coordination failures. A simple condition—absence of technological multiplicity—guarantees efficient investments for each pair, but a mismatch of agents may still occur. However, using optimal transport theory, I also show that mismatch is heavily constrained in certain multidimensional environments with differentiated agents and no technological multiplicity. Under technological multiplicity, even extreme ex ante heterogeneity need not preclude inefficiencies. (JEL C78, D41, D86)
The Benefits of State Aggregation with Extreme-Point Weighting for Assemble-to-Order Systems
Authors: Nadar Emre , Akcay Alp , Akan Mustafa , Scheller-Wolf Alan 
Published: July 2018

We provide a new method for solving a very general model of an assemble-to-order system: multiple products, multiple components that may be demanded in different quantities by different products, batch production, random lead times, and lost sales, modeled as a Markov decision process under the discounted cost criterion. A control policy specifies when a batch of components should be produced and whether an arriving demand for each product should be satisfied. As optimal solutions for our model are computationally intractable for even moderately sized systems, we approximate the optimal cost function by reformulating it on an aggregate state space and restricting each aggregate state to be represented by its extreme original states. Our aggregation drastically reduces the value iteration computational burden. We derive an upper bound on the distance between aggregate and optimal solutions. This guarantees that the value iteration algorithm for the original problem initialized with the aggregate solution converges to the optimal solution. We also establish the optimality of a lattice-dependent base-stock and rationing policy in the aggregate problem when certain product and component characteristics are incorporated into the aggregation/disaggregation schemes. This enables us to further alleviate the value iteration computational burden in the aggregate problem by eliminating suboptimal actions. Leveraging all of our results, we can solve the aggregate problem for systems of up to 22 components, with an average distance of 11.09% from the optimal cost in systems of up to 4 components (for which we could solve the original problem to optimality). The e-companion is available at https://doi.org/10.1287/opre.2017.1710 .
A Nonasymptotic Approach to Analyzing Kidney Exchange Graphs
Authors: Ding Yichuan , Ge Dongdong , He Simai , Ryan Christopher Thomas 
Published: July 2018

We propose a novel methodology to study kidney exchange. Using a random graph model of kidney exchange, we propose a nonasymptotic approach to quantifying the effectiveness of transplant chains in reducing the number of unmatched highly sensitized patients. Our approach is based on a two-phase random walk procedure where random walks are used to allocate chains, followed by allocation in cycles. The benefit of random walks is that they preserve the probabilistic structure of residual graphs, greatly facilitating analysis. Our approach allows us to analytically show the benefit of chains, as opposed to transplantation in cycles only, in nonasymptotic (medium-sized) graphs. We also derive useful analytical bounds that illustrate the performance of our proposed allocation procedure and more general kidney allocation procedures. Our results complement previous findings from analytical results in large (limit) graphs and empirical results based on data from fielded kidney exchanges demonstrating the benefits of chains. Moreover, our analysis sheds light on the relative importance of chains versus cycles in kidney allocation. In particular, our results show prioritizing chains over easy-to-transplant cycles, as opposed to prioritizing those cycles over chains, improves performance and provides analytical bounds on the associated benefits. A detailed simulation study numerically verifies our main results and provides additional insights. The online appendix is available at https://doi.org/10.1287/opre.2017.1717 .
Adherence to and Outcomes Associated with a Clostridium difficile Guideline at a Large Teaching Institution
Authors: Wieczorkiewicz Sarah , Zatarski RaeAnna 
Published: July 2018

Purpose The incidence and virulence of Clostridium difficile infection (CDI) has recently increased. National CDI treatment guidelines stratify patients based on clinical symptoms and recommend treatment based on severity of illness. In 2009, Advocate Lutheran General Hospital (Park Ridge, Illinois) adopted guidelines with treatment algorithms identical to the national guidelines. The purpose of this study was to determine whether patients were being treated in accordance with the CDI guidelines and whether adherence impacted patient outcomes. Methods This was a retrospective, descriptive study. Subjects were identified by CDI-associated ICD-9 codes from July 1, 2009 to June 30, 2011 and stratified by disease severity. Guideline adherence was assessed based on initial treatment selection, and subjects were then further categorized as undertreated (UT), overtreated (OT), or appropriately treated (AT). Secondary endpoints included need for therapy escalation, clinical cure, recurrence rates, 90-day all-cause mortality, proton pump inhibitor (PPI), and antimicrobial use. Results Two hundred fifty subjects totaling 324 encounters were analyzed. Overall guideline adherence was 42.9%. Adherence rates by CDI severity were mild-moderate, 53.9%; severe, 39.0%; and severe-complicated, 17.9% ( P < .001). Of all the subjects, 42.9% were AT, 30.9% were OT, and 26.2% were UT. Clinical outcomes between UT versus AT subjects were as follows: therapy escalation required, 34.1% versus 27.5% ( P = .289); clinical cure, 41.2% versus 55.7% ( P = .033); mortality, 24.7% versus 10.1% ( P = .003); and recurrence, 44.7% versus 24.8% ( P < .02). Clinical outcomes between AT versus OT subjects were as follows: therapy escalation required 27.5% versus 14.4% ( P < .02); clinical cure, 55.7% versus 66.7% ( P = .089); mortality, 10.1% versus 7.8% ( P = .553); recurrence, 24.8% versus 27.8% ( P = .871). Conclusions The majority of subjects were not treated according to CDI guidelines, particularly those with severe and severe-complicated disease. UT subjects had worse clinical outcomes and OT subjects failed to show significant improvements in clinical outcomes compared to AT subjects. Emphasis should be placed on CDI guideline adherence as this may be associated with improved outcomes.
Comparison of Practice Patterns between Inpatient Cardiology Pharmacists with and without Added Qualifications in Cardiology
Authors: Lose Jennifer , Dorsch Michael P. , DiDomenico Robert J. 
Published: July 2018

Background There is a paucity of data comparing practice patterns between board-certified specialists with added qualifications in cardiology (AQCV) and cardiovascular pharmacists without these credentials. Purpose The purpose is to characterize differences in practice between inpatient pharmacists with and without AQCV. Methods We conducted a multicenter, retrospective, cross-sectional, case-controlled survey. An AQCV pharmacist list was extracted from the Board of Pharmacy Specialties Web site. Hospitals with AQCV pharmacists comprised the case group. Hospitals were excluded if the AQCV pharmacists did not provide direct patient care, practiced in the outpatient setting, or were in a Veterans Affairs hospital. Each case hospital was matched to hospitals without an AQCV pharmacist in a 1:3 ratio (case:control) by region, cardiovascular discharges, and teaching hospital status. Institutions completed a survey characterizing their pharmacy services. Results Fifty-six hospitals completed the survey (21 AQCV, 35 non-AQCV). More AQCV pharmacists participated on rounds (100% vs 82.9%, P = .04) and devoted more time performing administrative tasks (20.5% ± 15.3% vs 11.1% ± 8.1%, P = .001) than non-AQCV pharmacists. Conversely, AQCV pharmacists spent less time providing clinical care (52.4% ± 14.5% vs 66.2% ± 19.8%, P = .007), were less involved with drug protocol management (71.4% vs 91.4%, P = .05), and performed less order verification than non-AQCV pharmacists. Conclusions Practice patterns differ between inpatient pharmacists with and without AQCV. Further research is needed to determine whether AQCV credentialing improves patient outcomes and to delineate what specific tasks performed by inpatient cardiology pharmacists may improve patient outcomes.
Compounded Pain Creams and Adverse Effects; Postanesthesia Care Unit ADC Selection Error; Docetaxel Product Has Unusual Concentration; Tragic Vaccine Diluent Mix-ups
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: July 2018

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers’ names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters’ wishes as to the level of detail included in publications.
New Insights into Predictors of Cardiac Implantable Electronic Device Infection
Authors: Sadeghi Hossein , Alizadehdiz Abolfath , Fazelifar Amirfarjam , Emkanjoo Zahra , Haghjoo Majid 
Published: July 2018

Infection is an important complication of cardiac implantable electronic device procedures. To further study the factors associated with infection, we retrospectively reviewed the records of 3,205 consecutive patients who had undergone de novo or revision cardiac electronic device implantation at our institution from March 2011 through March 2015. We recorded all infections and specified whether they were related to the characteristics of the patient, device, or procedure. To identify predictors of infection, we performed multivariate analysis.
Device infections were identified in 85 patients (2.7%), at a mean follow-up time of 27 ± 11 months. The main predictors of device infection were use of an implantable cardioverter-defibrillator or a cardiac resynchronization therapy defibrillator device (odds ratio [OR]=16; 95% CI, 4.14–61.85; P=0.0001), stage 3 chronic kidney disease (OR=9.41; 95% CI, 1.77–50.04; P=0.009), a revision procedure (OR=8.8; 95% CI, 3.37–23.2; P=0.0001), or postoperative hematoma (OR=6.9; 95% CI, 1.58–30.2; P=0.01). We also identified 2 novel predictors of infection: a low body mass index of <20 kg/m2 (OR=1.03; 95% CI, 1.01–1.06; P=0.005), and use of povidone-iodine rather than chlorhexidine-alcohol for topical antisepsis (OR=4.4; 95% CI, 2.01–9.4; P=0.03).
We conclude that comorbidities, device characteristics, procedure types, and postoperative noninfective complications all increase the risk of device infection after a cardiac implantable electronic device procedure.
Hybrid Method for Solution of Fractional Order Linear Differential Equation with Variable Coefficients
Authors: Ujlayan Amit , Dixit Ajay 
Published: July 2018

Abstract
In this paper, we proposed a new analytical hybrid methods for the solution of conformable fractional differential equations (CFDE), which are based on the recently proposed conformable fractional derivative (CFD) in R. Khalil, M. Al Horani, A. Yusuf and M. Sababhed, A New definition of fractional derivative, J. Comput. Appl. 264 (2014). Moreover, we use the method of variation of parameters and reduction of order based on CFD, for the CFDE. Furthermore, to show the efficiency of the proposed analytical hybrid method, some examples are also presented.
The inscriptions from the mound necropolis of Duvanlii (Thrace) and their socio-cultural context
Authors: Slavova Mirena 
Published: July 2018

Abstract
The article attempts to restore the socio-cultural context of four inscriptions found on various artifacts in graves from the mound necropolis at Duvanlii in Thrace (present day Bulgaria) dating back to the 5th century BC. They are written with a different technique - the erroneously transmitted graffito written in early Attic alphabet on the bottom of a plate ΙΠΠΟΜΑΧΣ, the depinti KOAΣ and ΚOMOΣ on a red-figure hydria, and the Thracian anthroponym ΔΑΔΑΛΕΜΕ engraved on four silver vases. The author focuses both on the interpretation of the single inscriptions (especially the placement of ΔΑΔΑΛΕΜΕ in a series with other known Thracian names, as well as with the newly published from Zoni) and on the contact zone of Thracians and Greeks in Thrace and Samothrace, whose specifics can explain the considered graphical practices.
A Greek reading of the “Pisidian” inscription N 30
Authors: Obrador-Cursach Bartomeu , Adiego Ignasi-Xavier 
Published: July 2018

Abstract
In this article, stele N 30 is removed from the Pisidian corpus because it is read as a plain Greek text containing the name of a man, Papas, said to be a gallus. Moreover, the relief of the same stele depicting a figure in woman’s clothing is interpreted as being Papas himself
Numerical Study on the Leakage Magnetic Field of Transverse Defect on T-Joint Fillet Weld
Authors: Pan Jiajing , Yang Lijun , Li Hang 
Published: July 2018

Abstract
A 3D finite element method model is established for yoke-magnetization detection of a transverse defect on T-joint fillet weld and solved by the finite element software ANSOFT Maxwell (ANSYS, Canonsburg, PA). The leakage magnetic field around the transverse defect is obtained. The relationship between the width of transverse defect and leakage magnetic field signals is identified. The researchers found that the tangential component of magnetic flux leakage density, BX1, tends to be a parabolic distribution and reaches the maximum value near the center of the defect along the length direction. While BX1 shows a bimodal distribution, featuring two peaks near the edge of the defect and one peak valley at the center along the width direction, the normal component of magnetic flux leakage density, BZ1, is very different than that of BX1 along the width direction, presenting an approximate N-shape as a whole. The leakage magnetic field signals of the transverse defect on the fillet weld of the T joint will decay obviously when the scanning line is perpendicular to the weld surface over 0.5 mm. The results of numerical simulation can provide a theoretical foundation to detect and characterize various defects in the fillet weld.
Interaction Studying in System GeO - B2O3 by Spectroscopic Methods
Authors: Zinchenko V.F. , Magunov I.R. , Mozgova O.V. , Nechyporenko G.V. , Stoianova I.V. 
Published: July 2018

Because of X-ray amorphous character of GeO and B2O3 for study of interaction between them methods of IR transmission spectroscopy and spectroscopy of diffuse reflectance are applied. Essential change of positionand intensity of bands of absorption in system GeO-B2O3 (H3BO3) at heating and thermal evaporation in vacuum is established. It is observed essential gypsochromic shift of short-wave border and bathochromic shift of long wave border of domain of an optical transparency of a coating compared with initial GeO that testifies in favour of change of the nature of a material. A coating from Germanium (ІІ) oxide exhibits high optical and operational parameters and are perspective for interference optics of an IR range of a spectrum.