bluuebunny/crossref_metadata_2025_split huggingface dataset:
Site-specific weathering of coatings: II. Comparison of natural weathering and accelerated protocols for Central Europe and Florida
Authors: Oehler Harald , Wanner Matthias , Aktas Lukas , Neumann Marie , Lellinger Dirk , Alig Ingo 
Published: December 2024

AbstractWeathering protocols, which anticipate exposure behavior of coatings in the temperate climate in Central Europe (ZykStuttgart: ZS) and Florida (new protocol: NP), were applied for accelerated testing of melamine-, silicone resin/acrylate dispersion-, and polyurethane-based coating systems and compared to natural weathering at related sites in Stuttgart (Germany) and near Homestead (Florida/USA), respectively. Color parameters and infrared spectra were measured after defined exposure times and normalized to the irradiation doses. Color changes of an industrial standard with an orange pigment (ORWET) were found to depend for both artificial and natural weathering tests predominantly on irradiation dose. This confirms that the spectral power distribution of the lamp/filter configuration proposed in NP matches sufficiently well to both the sunlight spectra in Florida and Stuttgart. For a melamine-based standard crack coat, crack initiation was found only for NP and the late stage of ZS. For all coating systems studied, characteristic band intensities of infrared spectra and/or color parameters for the two protocols and from natural weathering at the related outdoor sites were shifted along the time axis to merge to master plots. To differentiate between thermally activated, photo-initiated, and hydrolytic degradation, the shift factors were plotted versus inverse annual- or cycle-averaged temperatures including irradiation ratios and averaged humidity ratios. Despite the different reaction mechanism for the acrylic component in the silicone resin/acrylate and the polyurethane coating, a dominance of thermally activated degradation was evident for both. The melamine-based binder showed coupled degradation mechanisms (photo-induced and thermally activated complimented by moisture effects). The use of irradiation doses, cycle-, and annual-averaged temperatures together with cycle- and annual-averaged humidities for data analysis provided simple possibilities for comparison of protocols and weathering sites and a rough differentiation between degradation mechanisms.
JAK2 mutations in polycythemia vera: from molecular origins to inflammatory pathways and clinical implications
Authors: Bellosillo Beatriz , Doubek Michael , Tomuleasa Ciprian , Griesshammer Martin , Marchetti Monia , Sacha Tomasz , Gisslinger Heinz 
Published: December 2024

SummaryPolycythemia vera (PV) is a myeloproliferative neoplasm primarily driven by mutations in the JAK2 gene, most notably the V617F mutation, which occurs in nearly 97% of cases. This gain-of-function mutation overactivates the JAK-STAT pathway, a critical factor in developing the PV phenotype by stimulating excessive proliferation of the erythroblastic lineage. Diagnostic methods for PV focus on detecting the JAK2 mutation—primarily through polymerase chain reaction (PCR) and next-generation sequencing, which are essential for distinguishing PV from other disorders. The variant allele frequency (VAF) of JAK2V617F also serves as an important prognostic marker, with higher VAF linked to both increased thrombotic risk and disease progression to myelofibrosis or acute leukemia. Thus, managing allele burden is central to treatment strategies. Given the genetic complexity of PV, personalized treatment approaches are essential. Current therapies focus on JAK2 signaling, with ropeginterferon alfa-2b and JAK inhibitors as primary or secondary treatments to reduce clonal expansion and control inflammation, and aspirin to prevent thrombotic events. Emerging treatments are exploring anti-inflammatory strategies, such as anti-IL-1β antibodies, and agents targeting iron metabolism to maintain hematocrit levels without phlebotomy, potentially improving quality of life. Overall, reducing JAK2V617F burden and controlling inflammation are crucial for managing PV progression and improving patient outcomes, with ongoing research refining these therapeutic avenues to enhance long-term strategies.
Mythos „Kanzlerdemokratie“
Authors: Helms Ludger 
Published: December 2024

ZusammenfassungDie „Kanzlerdemokratie“ gehört seit Jahrzehnten zu den prominentesten und populärsten Labels, die dem deutschen Regierungssystem bzw. dem politischen Prozess in der Bundesrepublik zugedacht wurden. Zugleich ist die Rede von der „Kanzlerdemokratie“ längst zu einer nicht weiter hinterfragten „Worthülse“ verkommen. Der vergleichend angelegte Essay nimmt diesen Umstand zum Ausgangspunkt und zeichnet die erstaunliche Karriere des Terminus bzw. Konzepts nach und fragt nach dessen durchaus problematischen Implikationen für die politikwissenschaftliche Analyse von politischer Führung sowie für den demokratischen Prozess in Deutschland.
Metabolic acidosis and sudden infant death syndrome: overlooked data provides insight into SIDS pathogenesis
Authors: Goldwater Paul N. , Gebien Dov Jordan 
Published: December 2024

Abstract

Background
Decades of mainstream SIDS research based on the Triple Risk Model and neuropathological findings have failed to provide convincing evidence for a primary CNS-based mechanism behind putative secondary dyshomeostasis (respiratory or cardiac) or impaired arousal. Newly revealed data indicate that severe metabolic acidosis (and severe hyperkalemia) is a common accompaniment in SIDS. This supports the direct effect of sepsis on vital-organ function and occurrence of secondary CNS changes accompanied by the dyshomeostasis leading to SIDS.

Data sources
Using PubMed and Google Scholar literature searches, this paper examines how metabolic acidosis and sepsis might contribute to the underlying pathophysiologic mechanisms in SIDS.

Results
The discovery of a series of non-peer-reviewed publications provided the basis for a serious examination of the role of metabolic acidosis and sepsis in SIDS. Most SIDS risk factors relate directly or indirectly to infection. This consequently elevated the position of septic or superantigenic shock and viremia in causing secondary organ failure leading to SIDS. The latter could include diaphragmatic failure, as evidenced by peripheral respiratory (muscle) arrests in experimental septic shock, as well as infectious myositis and diaphragm myopathy in sudden unexpected deaths, including SIDS. In addition, just as acidosis lowers the threshold for ventricular fibrillation and sudden cardiac arrest, it could also contribute to similarly unstable diaphragm excitation states leading to respiratory failure.

Conclusions
This paper uniquely reveals compelling evidence for a connection between metabolic acidosis, sepsis, viral infections, and sudden unexpected child deaths and provides a solid basis for further work to define which pathway (or pathways) lead to the tragedy of SIDS. It is recommended that all autopsies in sudden unexpected deaths should include pH, bicarbonate, lactate, and electrolyte measurements, as well as diaphragm histology.
Performance improvements of virtual monoenergetic images in photon-counting detector CT compared with dual source dual-energy CT: Fourier-based assessment
Authors: Kawashima Hiroki , Ichikawa Katsuhiro , Yoshida Ryoichi , Katayama Takuto , Arimoto Makoto , Kataoka Jun , Nagata Hiroji , Kobayashi Satoshi 
Published: December 2024

AbstractTo confirm the performance improvement of virtual monoenergetic images (VMIs) for iodine contrast tasks in a clinical photon-counting detector CT (PCD CT) using Fourier-based assessment, compared with those in the latest-generation dual-source dual-energy CT (DECT). A water-filled bath with a diameter of 300 mm, which contains rod-shaped phantoms equivalent to diluted iodine (2 and 12 mg/mL), was scanned using PCD CT and DECT at 15, 7.5, and 3 mGy. VMIs were generated without any iterative reconstruction algorithm. Task transfer function (TTF), noise power spectrum (NPS), and slice sensitivity profile were evaluated for VMIs at 70 and 40 keV. The detectability index (d’) and the squared system performance function (SPF2) calculated by TTF2/NPS were compared. At 40 keV, the d’ values of PCD CT were higher (percentage increase of 25.7-39.9%) than those of DECT, whereas at 70 keV, the difference was rather small. The SPF2 values at 40 keV of PCD CT grew notably higher than those of DECT as the spatial frequency increased. The higher SPF2 values endorsed the lower image noise and the sharper edge of the rod phantom as observed. The d’ and SPF2 in VMIs at 40 keV of PCD CT were notably higher than those of DECT, which endorsed the clinical advantages of PCD CT that had been previously reported in various studies.
Higher Education in the US and Abroad: Historical and Contemporary Perspectives
Authors: Altbach Philip G. , Geiger Roger 
Published: December 2024

AbstractAt the start of the twentieth century, few Americans ever imagined getting a college degree. Less than 5 percent of children made it through high school, and approximately 1 percent of high school graduates enrolled in college. Two-year institutions were still a novelty, and four-year colleges catered to the 1 percent.1 Those numbers have changed dramatically. We now live in a world where 94 percent of Americans believe some college is “very important” to their lives and future prospects.2 Scholars tend to point to midcentury legislation—i.e., the GI Bill and Higher Education Act—as well as “College for All” movements as key drivers for the change. But the US isn’t alone. Globally, college-going has undergone a fundamental transformation during the past century. And the future promises the further expansion and reimagining of postsecondary education, though no doubt with surprising twists along the way.For this policy dialogue, we asked Roger Geiger and Philip Altbach to discuss the past, present, and future of higher education in the US and abroad. Roger Geiger is a distinguished professor emeritus of higher education at Penn State University. He has written extensively on higher education history, with particular attention to research universities. His recent works include The History of American Higher Education: Learning and Culture from the Founding to World War II and American Higher Education since World War II: A History. Philip Altbach is a professor emeritus at Boston College, where he was a research professor and distinguished fellow at the Center for International Higher Education. He has received the NAFSA: Association of International Educators Houlihan Award for Distinguished Service and the Association for the Study of Higher Education’s Howard R. Bowen Distinguished Career Award. Both bring decades of research experience, professional expertise, and personal insight to this discussion.HEQ policy dialogues are, by design, intended to promote an informal, free exchange of ideas between scholars. At the end of the exchange, we offer a list of references for readers who wish to follow up on sources relevant to the discussion.
Psychiatry’s New Validity Crisis: The Problem of Disparate Validation
Authors: Zautra Nicholas 
Published: December 2024

Abstract
In response to the DSM’s crisis in validity, psychiatry has seen a proliferation of alternative research frameworks (HiTOP, the Network Approach, RDoC) for studying and classifying psychiatric disorders. In this paper, I argue the existence of multiple frameworks in which each employs their own standards of validity is problematic methodologically speaking for trying to do any kind of unified validation work. Fundamental disagreements concerning the underlying phenomenon, sources of validating evidence, and the very nature of validity move each framework into an unrecognized plurality. The consequence for psychiatry is a new validity crisis.
Methodological and reporting recommendations for clinical trials in Nutritional Psychiatry: Guidelines from the International Society for Nutritional Psychiatry Research
Authors: Marx Wolfgang , Visser Marjolein , Wallace Caroline , Jacka Felice N. , Bayes Jessica , Francis Heather , Opie Rachelle , Hockey Meghan , Teasdale Scott B. , Sanchez Villegas Almudena , O’Neil Adrienne , Su Kuan-Pin , Rucklidge Julia J. , Berk Michael , Lopresti Adrian , Mischoulon David , Johnstone Jeanette M. , Staudacher Heidi M. 
Published: December 2024

Abstract
Research on nutraceutical and dietary interventions in psychiatry has grown substantially, but progress is hindered by methodological inconsistencies and limited reporting standards. To address this, the International Society for Nutritional Psychiatry Research presents the first guidelines on clinical trial design, conduct, and reporting for future clinical trials in this area. Recommendations were developed using a Delphi process including eighteen researchers with considerable clinical trial expertise and experience in either methodology, nutraceutical, or dietary interventions in psychiatry. These guidelines provide forty-nine recommendations for clinical trial design and outcomes, five for trial reporting, and seven for future research priorities. The recommendations included in these guidelines are designed to inform both nutraceutical and dietary clinical trial interventions in Nutritional Psychiatry. Common themes include an emphasis on the importance of a multidisciplinary research team and integration of co-design processes into the conduct and design of clinical research, methods to improve transparency and replicability of trial outcomes, and measures to address common biases in nutrition trials. Furthermore, we provide recommendations for future research including examining a greater variety of nutraceutical and dietary interventions, scalable delivery models, effectiveness and implementation studies, and the need to investigate these interventions in the prevention and management of less studied psychiatric conditions (e.g. schizophrenia and bipolar disorder). Recommendations included within these guidelines are intended to improve the rigor and clinical relevance of ongoing and future clinical trials in Nutritional Psychiatry.
French Law, Danish Cartoons, and the Anthropology of Free Speech
Authors: Candea Matei 
Published: December 2024

AbstractThe “Danish cartoons controversy” has often been cast as a paradigm case of the blindness of liberal language ideologies to anything beyond the communication of referential meaning. This article returns to the case from a different angle and draws a different conclusion. Following recent anthropological interest in the way legal speech grounds the force of law, the article takes as its ethnographic object a 2007 ruling by the French Chamber of the Press and of Public Liberties. This much-trumpeted document ruled that the Charlie Hebdo magazine’s republication of the cartoons did not constitute a hate speech offense. The article examines the form as well as the content of the ruling itself and situates it within the entangled histories of French press law, revolutionary antinomianism, and the surprisingly persistent legal concern with matters of honor. The outcome of the case (the acquittal of Charlie Hebdo) may seem to substantiate a view of liberal language ideology as incapable of attending to the performative effects of signs. Yet, a closer look challenges this now familiar image of Euro-American “representationalism,” and suggests some broader avenues of investigation for a comparative anthropology of liberalism and free speech.
Finn Malmgren and polar exploration
Authors: Alfei Pier Paolo 
Published: December 2024

Abstract
The research aims to reconstruct a transnational history of Finn Malmgren’s contribution to the exploration of the Arctic, with a specific focus on the polar air expeditions of Norge (1926) and Italia (1928). The analysis of archive sources consulted in Italy, Norway, and Sweden sheds light on some key aspects of these two expeditions. In particular, the study of numerous unpublished documents – from the correspondence with personalities such as Umberto Nobile and Anna Nordenskjöld to the contemporary testimonies of Adalberto Mariano and Filippo Zappi – offers new insights into issues such as the international meteorological cooperation during the preparation of the Norge expedition and the march on the pack of Malmgren, Mariano and Zappi.
Prolonged seed submersion influences germination and early seedling growth of Amazonian floodplain trees
Authors: Veiga Josephina B. , Piedade Maria T. F. , Franco Augusto C. , Costa Gilvan S. , Ferreira Cristiane S. 
Published: December 2024

AbstractSeeds of many Amazonian floodplain forest trees are dispersed during high-water periods and spend weeks or months underwater until the flooding retreats. To assess whether prolonged seed submersion affects germination and early seedling development, an experiment was carried out in a greenhouse with seeds of Campsiandra laurifolia, Cassia leiandra, Crataeva tapia, Ilex inundata, Macrolobium acaciifolium, Nectandra amazonum, Pouteria glomerata, Psidium acutangulum, Sorocea duckei, and Vitex cymosa. They are common in this type of forest, differ in fruit type, number of seeds per fruit, fruit dimensions, and fresh mass and have fruits or seeds that can float. Seeds were collected in a Central Amazonian floodplain forest (flooded approximately 6 months year−1; water column of 5 m) and germinated in (1) irrigated soil or (2) underwater (water column of 5–7 cm) for 6 months. Seeds that germinated underwater were transferred to drained soil. Seeds of all species germinated underwater and developed seedlings when transferred to soil. However, submersion reduced the germination percentage of Psidium acutangulum, N. amazonum, P. glomerata and V. cymosa. Six species delayed germination in water. Ca. leiandra, I. inundata and P. glomerata did not differ in mean germination time in drained soil and underwater, whereas S. duckei seeds germinated faster underwater. Seed submersion negatively affected seedling growth (shoot length) of three species but did not affect seedling biomass. Timing of fruit dispersal, fruit buoyancy and high number of seeds per fruit can be critical for species with seeds that are not as able to cope with long-term submersion.
Beyond perspectival vision: case studies of Wang Shu’s landscape painting-inspired parallel projection drawings
Authors: Jin Xin 
Published: December 2024

Despite the growing body of literature on Chinese architecture, contemporary Chinese architects’ critical approaches to drawing have received little scrutiny. To address this research gap, this essay examines the 2012 Pritzker Architecture Prize laureate Wang Shu’s creative uses of modern parallel projection methods. The essay focuses on Wang’s specific drawing strategies that have allowed him to reconcile the disengaged mode of seeing that is engrained in parallel projection with the immersive spectatorship that traditional Chinese landscape painting epitomises.First, through a literature review, this paper highlights Wang’s observations regarding the a-perspectival nature of Chinese landscape painting. Rather than being a perspectival window for the disengaged gaze, the landscape painting invites viewers to inhabit the pictorial space. Second, through comparative studies of selected cases, this essay investigates how Wang’s acknowledgement of the landscape painting’s a-perspectival traits has influenced his specific strategies when using parallel projection methods. The examined cases include Wang’s drawings for the Chen Mo Art Studio (Haiyan, 1998), the Tengtou Pavilion (Shanghai, 2009-10), and the Xiangshan Campus of the China Academy of Art Phases I and II (Hangzhou, 2002-08).The essay concludes by highlighting significant changes in Wang’s later parallel projection drawings. Wang’s work has increasingly delineated architectural terrains as sensory topographies to foster viewers’ time-bound immersive spectatorships. Moreover, when serving his architectural ideas, Wang’s drawings have transcended the geometric representation of depth by implying spaces that exceed the limits of projection drawings. By examining his drawings, this essay sheds light on a salient yet underexamined aspect of Wang’s architectural undertakings. By investigating in-depth case studies of contemporary Chinese architectural drawings, this essay takes a crucial step towards a better understanding of this hitherto understudied domain.
The Role of the Great Plains Low‐Level Jet in Moisture Transport, Streamflow, and Flooding in the Missouri River Basin
Authors: Wise Erika K. , Dannenberg Matthew P. , McCabe Gregory J. 
Published: December 2024

AbstractThe Missouri River Basin, one of the primary agricultural regions in North America, is prone to large hydroclimatic variability and extreme events. The Great Plains low‐level jet (GPLLJ) is one of the major sources of moisture transport into this region, and concerns over moisture extremes already seen in the interior U.S. have been linked to changes in GPLLJ. However, the relationship between GPLLJ and precipitation in this region remains uncertain, with studies showing conflicting results that may be related to distinct types of jet events. Here, we use daily GPLLJ data to study connections between different types of jet events and precipitation, integrated water vapor transport, and synoptic conditions to better understand GPLLJ‐streamflow linkages. We assess GPLLJ conditions during historical flood events and potential future changes using CMIP6 projections. We find: (a) in May–September, GPLLJ is associated with 29%–46% of monthly precipitation and with increased precipitation intensity; (b) GPLLJ has a consistently positive impact on Missouri River streamflow over the warm season; (c) coupled jets have a larger impact on moisture transport than uncoupled jets, but streamflow impact is reduced, likely due to seasonal timing; (d) unusual jet conditions preceded historical warm‐season flood events; and (e) future projections indicate relatively small changes in GPLLJ meridional wind velocities along with large increases in moisture transport driven by humidity increases. Although future streamflow will be partially dependent on snowmelt from the upper basin, the projected intensification of warm‐season moisture transport to the Missouri River suggests possible increases in future flood risk.