bluuebunny/crossref_metadata_2025_split huggingface dataset:
Administration of the Tablet Formulation of Olaparib in Patients with Ovarian Cancer: Practical Guidance and Expectations
Authors: Moore Kathleen N. , Birrer Michael J. 
Published: March 2018

Abstract

Olaparib is a poly(ADP-ribose) polymerase enzyme inhibitor that is approved for use in patients with advanced ovarian cancer (OC) and genetic BRCA1/2 mutations who have received three or more prior lines of chemotherapy for maintenance treatment of recurrent OC that is in response to platinum-based chemotherapy regardless of BRCA mutation status and for human epidermal growth receptor factor 2-negative metastatic breast cancer with deleterious or suspected deleterious germline BRCA mutations who have previously been treated with chemotherapy in the neoadjuvant, adjuvant, or metastatic setting. Because olaparib is poorly soluble and requires advanced drug delivery techniques to ensure bioavailability, the originally approved 400 mg dose is taken as eight 50 mg capsules twice daily. An alternative melt-extrusion tablet formulation was developed to improve the pharmacokinetic and pharmacodynamic profile of olaparib and reduce the pill burden for patients. The recommended tablet dose is 300 mg twice daily (two 150 mg tablets). Phase III studies with the tablet formulation are ongoing for multiple tumor types. Two studies conducted with the olaparib tablet formulation have reported results: one in platinum-sensitive, BRCA-mutated recurrent OC (SOLO-2) and one that included patients with germline BRCA-mutated metastatic breast cancer (OlympiAD). The tablet is the approved formulation based on the SOLO-2 trial results. Because the capsule and tablet formulations have different bioavailability, physicians must strictly adhere to the dosing instructions provided in the prescribing information. The tablet offers greater convenience for most patients, especially when using olaparib for maintenance therapy. This review discusses the differences between the two formulations, dose determination, and guidance for use of olaparib tablets by patients with OC. Prior to implementing any changes in therapy, health care providers should engage their patients in discussion to support an informed transition between the formulations.

Implications for Practice
Olaparib has recently been approved for maintenance treatment of recurrent ovarian cancer (OC) that is in response to platinum-based chemotherapy. The originally approved capsule formulation was dosed as 400 mg twice daily (eight 50 mg capsules). The recommended olaparib tablet dose is 300 mg twice daily (two 150 mg tablets). The tablet is the new approved formulation based on the SOLO-2 trial results. Because the capsule and tablet formulations have different bioavailability, physicians must strictly adhere to the dosing instructions provided in the prescribing information. The tablet offers greater convenience for most patients, especially when using olaparib for maintenance therapy. This review discusses the differences between the two formulations, dose determination, and guidance for use of olaparib tablets by patients with OC.
Arte e ideas sobre Naturaleza/ Art and ideas about Nature
Authors: Jaime Carbonel Alejandro 
Published: March 2018

El presente ensayo reflexiona acerca de las distintas perspectivas conceptuales de lo que entendemos por Naturaleza y cómo ellas configuran nuestra realidad y nuestros quehaceres colectivos. Esta reflexión parte desde el ámbito artístico para después incorporar aspectos de la ecología política en la dialéctica Humano/Naturaleza, enfatizándo los puntos comunes y las intersecciones que consideramos interesantes. Tomamos tres ejemplos en la historia del arte reciente en donde identificamos las problemáticas conceptuales en torno a la configuración de la idea de lo natural. Primero desarrollaremos aspectos de la intersección entre arte y ciencia en los proyectos enciclopédicos y el impacto de la cartografía como la imagen que encarna dicha intersección. El segundo ejemplo presenta una mirada renovada hacia lo natural con el paisaje entrópico de Robert Smithson. El tercer ejemplo, la obra de Stelarc, reconfigura “Lo Natural” ante el impacto tecnológico de la civilización. Estas referencias nos sirven para ilustrar y desarrollar el debate de las ideas en la contemporaneidad acerca de la construcción cultural de la Naturaleza a través del arte y cómo este debate toma forma y es difundido por canales políticos que comparten o resisten los programas del poder para la permanente configuración de las representaciones del mundo.
Abstract
This essay reflects on the different conceptual perspectives of what we understand by Nature and how they shape our reality and our collective tasks. This reflection starts from the artistic field and then incorporates aspects of political ecology in the Human / Nature dialectic, emphasizing the common points and the intersections that we consider interesting. We take three examples in the history of recent art where we identify the conceptual problems around the configuration of the idea of ??the natural. First, we will develop aspects of the intersection between art and science in encyclopedic projects and the impact of cartography as the image that embodies this intersection. The second example presents a renewed look towards the natural with the entropic landscape of Robert Smithson. The third example, the artwork of Stelarc, reconfigures the Natural before the technological impact of human development. These references serve to illustrate and develop the debate of contemporary ideas about the cultural construction of Nature through art and how this debate takes shape and is disseminated through political channels that share or resist the programs of power for the permanent configuration of the representations of the world.
Allpa Mama: relaciones sociedad-naturaleza, procesos sociales y agencialidad/ Allpa Mama: society-nature relations, social movements and agency
Authors: Valdivieso Kastner Natalia Catalina , Premauer Marroquín Anna 
Published: March 2018

Para las mujeres kichwas que habitan las cuencas de los ríos Bobonaza y Curaray en la provincia de Pastaza, Ecuador, moldear cerámica es no solo una actividad femenina por excelencia, sino que esta implica un modo de relacionamiento con los seres humanos y no humanos que habitan su entorno. En la actualidad, esta experiencia de vida se ha visto en riesgo a partir de las licitaciones petroleras que desde el 2012 se adelantan en la Amazonía ecuatoriana. Frente a la amenaza que podrían constituir las concesiones extractivas, varias mujeres kichwas -la mayoría ceramistas- se han levantado políticamente manifestando su descontento y abogando por la preservación de sus territorios. El presente artículo tiene como objetivo exponer cómo las mujeres kichwas de Pastaza, entablan relaciones con el territorio y la naturaleza a través de sus cuerpos y del tejido de la cerámica. Se plantea que el moldeamiento del barro aparece como un dispositivo que, además de evidenciar esta relación, se ha convertido en un medio económico y político a través del cual las mujeres kichwas tejen redes y obran en defensa de la reproducción de la vida tal y como ellas la conciben.
Abstract
For the Kichwa women living at the Bobonaza and Curaray river basins, in the Pastaza Province, Ecuador, molding ceramics is not just an activity women should take care of, but it also implies a way of relating to other human and non-human beings inhabiting in their environment. It also conveys a relationship with the materials and social and symbolic structures that give meaning to their experience. Since 2012 oil extraction tenders in the Ecuadorian Amazon have been posing a threat to their life experience. In this context of threats associated to extractive concessions, a number of Kichwa women –most of them ceramists– have become politically active and put forth their voice of disagreement to advocate the preservation of their territories. This paper seeks to illustrate how Kichwa women from Pastaza establish relationships with nature and territory through their bodies and the activity of “knitting” ceramics. It is argued that the activity of molding clay is both evidence of this relationship, and of economic and political means through which Kichwa women knit social networks and become agents in defending their territories.
Narrativas del cine ambiental en Buenos Aires: ¿discursos expertos o enfoques alternativos?/ Narratives of the Environmental Films in Buenos Aires: Expert’s Speeches or Alternative Approaches?
Authors: Fernández Bouzo Soledad 
Published: March 2018

El presente artículo analiza y compara las principales narrativas que los distintos dispositivos institucionales de cine ambiental ponen en circulación en Buenos Aires a través de sus películas documentales. Las preguntas clave son: ¿qué tipo de narrativas y enfoques del ambientalismo movilizan tales dispositivos?, ¿a través de qué argumentos lo hacen?, ¿predominan en ellos discursos expertos que confían en la potencialidad de ciertos cambios culturales y/o en las innovaciones científico-tecnológicas dentro de las economías capitalistas globales?, ¿o más bien encontramos enfoques alternativos que cuestionan las bases mismas del capitalismo en la actualidad? Con el fin de contestar los interrogantes, llevamos adelante un análisis sociológico en dos niveles: uno de orden institucional, orientado a caracterizar las redes de actores que se conforman alrededor de los dispositivos de cine ambiental, y otro nivel de carácter narrativo, cuyo objetivo es rastrear los distintos enfoques y discursos sobre la cuestión ambiental.
Abstract
This article analyzes and compares the main narratives circulated by different environmental film institutional devices in Buenos Aires through their documentary films. The key questions are: What type of narratives and approaches of environmentalism mobilize such devices? Which arguments are used? Are they dominated by expert’s speeches which rely on the potential of certain cultural changes and/or science and technology innovations within global capitalist economies? Or rather are they alternative approaches questioning the very foundations of capitalism today? In order to answer those questions, we conducted a sociological analysis on two levels: an institutional one, aimed at characterizing the networks of actors that are formed around the environmental film devices, and a narrative one, the purpose of which is to track the main speeches and approaches on the environmental issue.
Achievement Indicators for Sustainable Development Goals in Education and National Education Policies
Authors: Agranovich Mark 
Published: March 2018

The 2030 Agenda for Sustainable Development, or “action for people, planet and prosperity”, was adopted by the United Nations in 2015. An important role belongs to the education, which embraces ten targets. Currently, the international community coordinating by UNESCO is actively developing a set of indicators to reflect the level of the education goal and targets achievement. The article investigates the possibility of using a common set of indicators for countries with vastly differing socioeconomic conditions and levels of education system development and applying universal indicators to elaborate national education policies in different countries. Context analysis of the indicators of sustainable development goal and targets achievement, and differences in the interpretation of the indicators depending on specific country characteristics are analyzed.
Lifelong Learning in the Context of Economic Development and Government Effectiveness
Authors: Korshunov Ilya , Gaponova Olga 
Published: March 2018

Statistical data is used to analyze formal and supplementary adult education attainment rates in the European Union, OECD countries and Russia depending on the basic economic development characteristics and the government effectiveness index that the World Bank has used to assess the quality of governance for the last two decades. In countries with low GDP, formal and supplementary adult education attainment rates are linearly dependent on the size of investment in fixed capital and show weak correlation with the index of government effectiveness. In countries with high levels of GDP and active investment processes, the key role in the growth of formal and supplementary education attainment rates is played by governmental actions that prompt the population and employers to engage in learning and supplementary education programs. Region-specific Federal State Statistics Service (Rosstat) data shows similar correlations between engagement of the employed population in lifelong learning and economic development indicators. The study includes analysis of official development strategies and the existing lifelong learning policies pursued by the countries as well as national cases that include the content of education programs, target groups and measures to maintain the adult population’s access to lifelong learning. Incentives to increase formal and supplementary adult education attainment rates are identified, and the relationship between their implementation and economic development of countries is determined.
Конструирование старения: секс и интимность в пожилом возрасте
Authors: Зеликова Юлия Александровна 
Published: March 2018

Юлия Александровна Зеликова – к.с.н., доцент Северо-западного института управления РАНХиГС, Санкт-Петербург, Россия. Электронная почта: zelikova-ia@sziu.ranepa.ru
Статья посвящена изучению интимных и сексуальных отношений в пожилом возрасте. Дискурс о старении в современном обществе строится вокруг утверждения, что с возрастом снижаются способности, потребности и желания, в том числе сексуальные. Старение воспринимается обществом как поражение человека, как неспособность жить вне заданных характеристик возраста. Цель статьи – продемонстрировать ошибочность представлений о сексуальности в пожилом возрасте. Исследование исходит из конструктивистского похода, в рамках которого старение – это процесс, обусловленный социальными институтами. В фокусе исследования находятся общественные стереотипы о сексуальной жизни пожилых людей, нормы поведения, приписываемые обществом, и социальные ожидания, влияющие на личную интимную жизнь в пожилом возрасте. Эмпирической базой являются 18 нарративных интервью с людьми в возрасте от 65 лет до 81 года. Анализ интервью реконструирует сексуальные проблемы, с которыми сталкиваются люди пожилого возраста, позволяет увидеть их новый сексуальный опыт и понять, какой смысл они придают интимности и телесности. Особое внимание уделяется тому, как пожилые партнеры поддерживают отношения друг с другом. В статье показано, что в современной России конструирование пожилого возраста осуществляется, в частности, с помощью контроля над сексуальностью в форме отказа пожилым людям в праве на сексуальную активность. Интимность, телесность и сексуальность пожилых людей воспринимаются как отступление от нормы и несоответствие ожиданиям. Такое явление следует описывать как эйджизм, поскольку эти практики производят маргинализирующий и стигматизирующий дискурс в отношении пожилых людей.
International Policy Frameworks on Ageing: Assessing Progress in Reference to the Madrid International Plan of Action on Ageing
Authors: Sidorenko Alexandre , Zaidi Asghar 
Published: March 2018

Alexandre Sidorenko – Senior Advisor, European Centre for Social Welfare Policy and Research, Vienna, Austria. Email: sidorenko.alexandre@gmail.com
Asghar Zaidi – Professor in International Social Policy, University of Southampton, UK. Email: Asghar.Zaidi@soton.ac.uk
The central goal of this article is to review progress made in implementing the international policy frameworks on ageing, focusing on the Vienna International Plan of Action on Ageing (VIPAA) and in more detail on the Madrid International Plan of Action on Ageing (MIPAA). The article offers a critical examination of the current approaches to monitoring and assessing the implementation process, outlining promising avenues for the future. In this way, the limitations of the current procedures for following the policy priorities of the MIPAA can be highlighted. What is found is that progress in many countries is hampered by inherent subjectivity in assessing and reporting advancement, lack of continuity and consistency, and difficulties in comparing the national level progress with international development in the same areas. The current year, 2017 / 2018, is momentous as we reach the end of the third five-year implementation cycle of the MIPAA. Introspection now should not merely focus on assessing the progress made but also on how the implementation of the MIPAA could be strengthened. In the same spirit, the 2030 Agenda of Sustainable Development Goals presents new opportunities; especially its pledges 'Leave no one behind' and 'Reach the furthest behind first', which imply that the older population can serve as agents of development. In moving forward, an essential requirement will have to be the establishment of an internationally acceptable set of indicators, which can be employed for assessing national progress in addressing the challenges and opportunities of ageing and monitoring the international efforts to implement international policy frameworks like the MIPAA. Along the lines of the dashboard of indicators used in the Active Ageing Index 'AAI', there should be a MIPAA monitoring toolkit with different layers of indicators, which are aligned with the three priority directions of the MIPAA.
Re-imagining Russia’s Social Care System in the Age of the Internet: the Gerontological NGO Dobroe Delo, the Madrid Plan, and the Rights of the Elderly
Authors: Harris Jane 
Published: March 2018

Jane Gary Harris – Professor emerita, Department of Slavic Languages, Literatures and Cultures, and MSW in Gerontology, University of Pittsburgh, USA. Email: jgharris@pitt.edu
enced significant challenges and changes. This paper explores the rationale behind those challenges and the agency behind the changes. In doing so it raises several questions: it asks what role NGOs, and more specifically, Gerontological NGOs, played in advocating for and bringing about change, where and how they may or should be credited with helping to re-imagine a modern aging policy for the Russian Federation, and what implications this may have for aging policy priorities in the present and imminent future? It proposes that the incipient Gerontological NGO sector was instrumental in re-imagining a modern social care system for older persons – the basis for a modern comprehensive aging policy: by, among other things, utilizing the internet in the social sphere to advocate for the principles and recommendations of the United Nations model Madrid Plan; by advocating for the rights of the elderly; by calling for integrated social and medical care; and by linking gerontological research and aging policy. An inquiry into the nature of the influence of these NGOs on aging policy priorities required a micro-level examination of the particularly influential Gerontological NGO Dobroe Delo, suggesting its seminal role in unifying an inchoate Gerontological NGO sector, while simultaneously transforming the basic paradigm of aging policy to focus on the 'Rights of the Elderly.' In addition, this paper proposes that such research is critical to understanding how Russia’s aging policy has been re-imagined over the past decade and a half while asking what policy issues yet remain to confront future demographic demands.
Горький хлеб старости? Социальные практики питания пожилых людей
Authors: Веселов Юрий Витальевич , Таранова Ольга Александровна , Цзинь Цзюнькай 
Published: March 2018

Юрий Витальевич Веселов – д.с. н., профессор, заведующий кафедрой экономической социологии, факультет социологии, Санкт-Петербургский государственный университет, Санкт-Петербург, Россия. Электронная почта: yurivitalievichveselov@yahoo.com
Ольга Александровна Таранова – ассистент кафедры экономической социологии, факультет социологии, Санкт-Петербургский государственный университет, Санкт-Петербург, Россия. Электронная почта: o. a.taranova@gmail.com
Цзюнькай Цзинь – аспирант кафедры экономической социологии, факультет социологии, Санкт-Петербургский государственный университет, Санкт-Петербург, Россия. Электронная почта: j530519513@126.com
Одна из важных задач социологии питания – исследование социальной дифференциации и повседневных практик потребления продовольствия различными социальными группами населения. В статье рассматриваются вопросы питания пожилых людей. На основе эмпирического исследования «Еда и мы» и анализа статистики, мы показываем, как обстоит дело с питанием пожилых людей. Вопреки устоявшемуся стереотипу – старики питаются очень плохо, мы утверждаем, что в группе пожилых людей есть существенные различия. Базовым фактором, определяющим такую модель потребления, является образование, формирующее рациональный и систематический подход к потребляемой пище. В первой части статьи рассматривается предмет социологии питания и ее теоретические основания. Мы утверждаем, что процессы потребления еды социально структурированы и институциализированы. Вкус к еде пожилых людей определен их габитусом, который формировался еще в советское время тотального дефицита продуктов питания (отсюда склонность пожилых людей делать запасы). Он зависит как от экономических возможностей, так и от обладания культурным капиталом. Еда – это система коммуникации, она всегда обозначает определенную социальную ситуацию: разговоры пожилых людей вращаются вокруг рынков, магазинов, цен на продовольствие, акций супермаркетов, возможностей приготовления различных блюд. Так еда тематизируется и наполняется смыслом. Затем мы рассматриваем структуру и режимы питания пожилых людей (на основе статистических данных Росстата и Петростата); основная проблема – несбалансированная диета пожилых людей, перекос в сторону дешевой углеводной пищи, при дефиците белков и полезных жиров. Мы исследуем социальные различия в питании пожилых людей; еду вне дома как фактор их социализации; изучаем взаимосвязь здоровья и питания, а также социально-психологическое отношение к еде. В заключении подводятся итоги и даются практические рекомендации по созданию системы здорового питания пожилых людей.