bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperatif pulmoner komplikasyonları öngörmede yaşam kalitesinin önemi
Authors: GÜLŞEN Aşkın 
Published: September 2019

Amaç: Abdominal
cerrahilerde postoperatif pulmoner komplikasyonlar (PPK), morbitide ve
mortalitenin önemli bir nedenidir. Ayrıca hastanede yatış süresini uzatan
önemli bir faktördür.Preoperatif değerlendirme,
komplikasyonların tahmin edilmesinde ve önlem alınmasında önemli bir yer
oluşturmaktadır. Değerlendirme sıklıkla öykü, fizik muayene, akciğer grafisi,
solunum fonksiyon testleri, gerekli olgularda arteriyel kan gazı, ve egzersiz
testleri ile yapılmaktadır. Bu çalışmada, diğer değerlendirme parametrelerinden
farklı olarak PPK’ı öngörmede yaşam kalitesinin önemini araştırmayı amaçladık.Yöntem:
Çalışmamıza
Genel Cerrahi AD’da elektif batın cerrahisi yapılacak olan 124 hasta
alınmıştır. Hastalar ameliyat öncesi 1 haftalık dönemde değerlendirilmiş ve
nottingham sağlık profili (NSP) skoru hesaplanmıştır. Postoperatif 48.saat
sonrasında semptomlar ve komplikasyonlar incelenerek, preoperatif NSP değerleri
ile karşılaştırılmıştır.Bulgular PPK görülen
hastalarda NSP-total puanı ort. 125,71 ± 114,09 puan ve
görülmeyenlerde ort. 63,65 ± 72,75 puandı
(p=0.002). Fiziksel mobilite, ağrı, enerji düzeyi, duygusal reaksiyon, uyku
durumu, ve sosyal izolasyon düzeylerine göre yapılan değerlendirmede emosyonel
durum haricinde diğer tüm puanlar komplikasyon görülen hastalarda daha yüksek
saptandı. Mortalite görülen hastaların ort. 209,31 ± 130,74 puan olduğu görüldü. Hastalar NSP puanlarına göre grup-1 (0-49,9), grup-2
(50,0-99,9), grup-3 (100-149,9) ve grup-4 (&gt;150 puan) olarak
sınıflandırıldı. Buna göre grup-4 olan hastalarda %72,7 pulmoner
komplikasyon görüldü (p&lt;0.001). Yine 150 puan ve üzeri olan hastalarda
solunumsal komplikasyonlar 7,6 kat, solunum dışı komplikasyonlar ise 6,7 kat
artmış bulundu.

Sonuç: Çalışmamız,
hastaların NSP puanı 150 ve üzerinde olması durumunda komplikasyonların daha
fazla olduğunu göstermiştir. Ayrıca NSP sağ kalımı da iyi predikte etmiştir. Bu
sonuçlar ile NSP’nin preoperatif risk değerlendirmede yararlı olabileceği
düşünülmüştür.
INFLUENCE OF HEPARINOID FROM PAEONIA LACTIFLORA ON HEMOSTATIC SYSTEM WITHIN CONDITIONS OF PRETHROMBOSIS
Authors: Lyapina M. G. , Uspenkaya M. S. , Maistrenko E. S. , Kalugina M. D. 
Published: September 2019

The search and development of direct and rapid anticoagulants used per os, is an urgent problem in physiological and medical science. A number of plants contain heparin-like components with a positive effect on the hemostatic system, both within normal and in some pathological conditions of the body.The aim of the work was to study the complex effect of fibrin, a heparin-like substance (heparinoid) from the roots of Paeonia lactiflora, on fibrinolytic, anticoagulant systems of the body and polymerization processes, when it is administered per os in animals within normal conditions and when modeling the state of prethrombosis.Materials and methods. To carry out the research, the roots of Paeonia lactiflora growing in the Botanical Garden of Moscow State University, and laboratory animals – male Wistar rats – were used. To study the antithrombotic effects of the extract from roots containing heparinoid, the state of prethrombosis was modeled in rats. The determined parameters of hemostasis were: anticoagulant activity according to the tests of activated partial thromboplastin time and thrombin time, fibrinolytic activity according to the test of total fibrinolytic activity, fibrin polymerization according to the test of fibrindepolymerization activity of blood plasma.Results. With repeated (every 24 hours within 3 days) oral administration of the extract containing heparinoid, in animals within normal conditions and with prethrombosis, the following anticoagulant effects were established in the blood: an increase in anticoagulant, fibrindepolymerization and fibrinolytic plasma activity. Possible mechanisms of the activating effect of heparinoid on fibrinolysis and anticoagulant properties of plasma due to the excretion of tissue plasminogen activator into the bloodstream from the endothelium, thrombin inhibition, and fibrin polymerization are described. Moreover, the anticoagulant effect of the use of the extract from the peony roots was equivalent to that of the reference drug of low molecular weight heparin from Celsus (USA). For the first time, it was revealed that when modeling experimental prethrombosis, the administration of heparinoid in rats at the dose of 37.5 IU/kg МЕ/кг body weight restored impaired hemostasis, which requires a further study.Conclusion. The ability of heparinoid from peony roots to normalize the functional state of the anticoagulant system during the development of prethrombosis in animals has been established. The restriction of fibrin polymerization during oral administration of heparinoid from peony in animals by increasing the enzymatic fibrinolytic and fibrindepolymerization activity of blood plasma was revealed. In the future, heparinoid can be used as an antithrombotic agent.
APPLICATION OF DRUG-RELATED PROBLEMS APPROACH TO ANALYSIS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS’ SAFETY
Authors: Matveev A. V. , Krasheninnikov A. E. , Egorova E. A. , Konyaeva E. I. 
Published: September 2019

A Drug-Related Problem is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes.The aim of the study was the analysis of the adverse drug reactions (ADR) associated with prescription of the non-steroidal anti-inflammatory drugs (NSAIDs) using the DRP PCNE V5.01 qualification system.Materials and methods. The objects of the study were 415 notification forms about adverse drug reactions of NSAIDs recorded in the regional database of spontaneous reports and called ARCADe (Adverse Reactions in Crimea, Autonomic Database) for the period from 1 January 2009 to 31 December of 2018. The study and analysis of the problems associated with drugs were carried out using the qualification system DRP PCNE V5.01 (Pharmaceutical Care Network Europe) 2006 in the modification of Prof. Zimenkovsky.Results. Among other representatives of the NSAID group, Ibuprofen and Diclofenac became the “leaders” in the incidence of ADR. The frequency of ADR cases for Ibuprofen was 142 reports (34.22% of the total number of ADR for NSAIDs), and for Diclofenac it was 90 cases (21.69%). The calculation of DRP values for each of the presented cases made it possible to determine that in 81 (19.51%) and 91 (21.9%) cases, the DRP value was 6 and 7, respectively. DRP values in the range of 8–10 were found in 92 reports. The highest DRPs value was observed after the administration of Parecoxib (13 problems but only one case was found in the database), the DRPs value of Dexketoprofen was 12.5 (95% CI: 7–17) and the DRPs value of Diclofenac combinations was 10 DRPs; 95% CI: 5–17 DRP). The minimum DRPs values were associated with Naproxen, Rofecoxib, and Etoricoxib prescriptions.Conclusion. Using the DRP system in the analysis of NSAIDs, ADRs allow to identify the medicines which have a high risk of causing safety problems, such as Parecoxib, Dexketoprofen and Diclofenac combinations. The prescription of these drugs should be carried out with special cautions and control to the indications and contraindications, the dose and duration of treatment, as well as to a possible interaction of them with concomitant drugs.
GLYPROLINES AS MODULATORS OF IMMUNOREACTIVITY WITHIN CONDITIONS OF “SOCIAL” STRESS
Authors: Samotrueva M. A. , Yasenyavskaya A. L. , Bashkina O. A. , Myasoedov N. F. , Andreeva L. A. 
Published: September 2019

The most important direction in the development of modern medical science is the study of protective, compensatory and pathological reactions of the organism that occur in response to various stress factors.The aim of the study is the subsequent development of methods for pharmacological correction of these reactions. The remedies for the correction of stress-induced immunity disorders are represented by the glyprolin group – the Selank drug and the Pro-Gly-Pro peptide compound – and are of particular interest. The aim of the experiment was to study the immunomodulating effect of glyprolines on the basis of the “social stress” model.Materials and methods. The experiment was performed on non-linear male rats aged 6-8 months. A model of a sensor contact was used as a model of the experimental “social stress”. The animals were divided into groups (n = 10): a “control” group was represented by individuals with aggressive and submissive types of behavior, formed within the conditions of the experimental “social stress” for 20 days; and 2 experimental groups in which the animals were intraperitoneally administered Selank (100 µg/kg) and Pro-Gly-Pro (100 µg/kg) against the background of the experimental “social” stress once a day for 20 days. A functional activity of the immune system was studied on the basis of standard immunopharmacological tests: a delayed-type hypersensitivity test (DTH test), a direct agglutination test (DAT), a latex test for studying the Neutrophil phagocytic rate of peripheral blood, and the essessment of the leucogram.Results. It has been established, that within the conditions of the “social” stress, the changes in the immune response are multidirectional. That fact confirms the theory of “the immune disbalance” caused by the action of stressors. As a result of studying the effect of glyprolines within the conditions of “the social stress”, Selank and Pro-Gly-Pro proved to be effective immunocorrectors, restoring cellular and humoral immunogenesis reactions as well as the phagocytic activity of neutrophils and leucogram indices.Сonclusion. The carried out study expands understanding of the immunoreaction pathogenesis within the stress-induced conditions in order to further develop a pharmacological strategy for correcting the revealed disorders through the substances of the neuropeptide structure.
Projetos na escola pública: a percepção dos alunos
Authors: Santos Marlene 
Published: September 2019

Este artigo apresenta resultados parciais de uma pesquisa de abordagem qualitativa sobre as percepções de um grupo de estudantes do Ensino Médio da rede pública estadual de São Paulo sobre a utilização da estratégia de projetos no ensino de Filosofia. A coleta de dados foi realizada a partir da aplicação de um questionário semiestruturado a um grupo de 15 alunos, provenientes de sete diferentes turmas do terceiro ano do Ensino Médio. Os dados coletados e analisados reforçam nossa concepção, também presente em diversos estudos recentes, sobre a necessidade de maior adequação das práticas pedagógicas às necessidades e aos interesses dos educandos.
O acervo da Escola Técnica Estadual Henrique Lage como fonte de pesquisa para a história da educação fluminense
Authors: Costa Nailda Marinho da , Ignácio Sâmela Cristinne Furtado de Carvalho 
Published: September 2019

O artigo trata do uso e do potencial do acervo da Escola Técnica Estadual Henrique Lage como fonte de pesquisa para a história da educação fluminense. Acervo localizado em dois espaços distintos no interior da instituição escolar: no Centro de Memória Henrique Lage e no arquivo da escola. O primeiro se constitui como um espaço de pesquisa e recuperação da memória da escola criada em 1923 como escola profissional para meninos e que hoje integra o conjunto de seis escolas técnicas centenárias da Fundação de Apoio à Escola Técnica do Rio de Janeiro; o segundo se constitui como um setor ligado à secretaria escolar que é alvo de atuação do primeiro, tendo em vista que no arquivo se encontra uma documentação produzida e acumulada pela instituição escolar desde a sua criação, portanto de valor histórico, até os dias atuais.
Professores-narradores de pessoas trans*: experiência e metodologia em Itaboraí
Authors: Brasil de Moraes Cristiano Da Silva 
Published: September 2019

O que dizem professores de pessoas trans* de uma cidade na região metropolitana do Rio de Janeiro sobre sua educação, seu convívio em sala de aula e seu processo de escolarização? A partir da colaboração dos estudos de gênero e sexualidade e da história da educação e da profissão docente, as narrativas desses educadores e educadoras da cidade de Itaboraí sobre seus alunos foi registrada, dando corpo auma dissertação de mestrado. Neste texto, apontamos quais caminhos metodológicos foram tomados e comentamos parte dos discursos desses agentes da educação.
Liver Functional Evaluation Using Gadoxetic Acid Versus the Gold Standard Hepatobiliary Scintigraphy in Patients with Bile Duct Diseases
Authors: Shorikov M. A. , Sergeeva O. N. , Kashkadaeva A. V. , Averinova S. G. , Lapteva M. G. , Frantsev D. Yu. , Polyakov A. N. , Kudashkin N. E. , Alekhin A. P. , Moroz E. A. , Virshke E. R. , Dolgushin B. I. 
Published: September 2019

Objective. To compare liver function assessments using Gd-EOB-DTPA-enhanced MRI and the gold standard hepatobiliary scintigraphy (HBS) in patients with bile duct diseases.Material and methods. The investigation enrolled 18 patients (male/female = 11/7; age, 29–70 years, Klatskin tumor (n=16), bile duct epithelial dysplasia (n=1), intrahepatic cholangiolithiasis (n=1)) after biliary decompression, who underwent 21 paired MRIs and 99mTc-mebrofenin HBS at a study interval of no more than 3 days. In the same regions of interest with a size of 30–50 pixels located in liver segments II–III, IV, V–VIII, and VI–VII, a MRI signal was measured before MR contrast agent (MRCA) injection into the standard vascular phases and at 10, 20, 30 and 40 minutes, then the signal was expressed as a percentage of intensity compared to the precontrast series. After MR volumetry, the functional volumes of the left and right liver lobes were also defined as the area under the MRCA accumulation curve, which was multiplied by the lobe volume and expressed as a percentage of the similarly calculated function of the entire liver. Similar intensity parameters and functional volumes were estimated for a HBS study.Results. The lobe functional volumes measured by the two methods were highly correlated (R=0.8; p<0.001) and did not show a significant difference at all when comparing with the Mann–Whitney test (p>0.3). The excretion rate of 99mTc-mebrofenin was also highly correlated with MRI findings (R=0.5–0.9; p<0.05). Conclusion. Gd-EOB-DTPA-enhanced MRI revealed a high correlation with the gold standard; however, additional studies are needed to clarify the possibilities and limitations of replacing one method with another one.><0.05).Conclusion. Gd-EOB-DTPA-enhanced MRI revealed a high correlation with the gold standard; however, additional studies are needed to clarify the possibilities and limitations of replacing one method with another one.
Invasive Mucormycosis with Lung Involvement in a Female Patient with Aplastic Anemia
Authors: Sheikh Zh. V. , Tyurin I. E. , Sinopal’nikov A. I. , Arablinskiy A. V. , Safonova T. D. , Fedyaeva E. V. , Murav’ev O. B. , Shvayko S. N. 
Published: September 2019

Mucormycosis is an infection caused by one of several types of mold. Invasive mucormycosis is the most aggressive, rapidly progressive fungal infection. The disease is characterized by high attributable mortality. The early and accurate diagnosis of invasive mucormycosis determines the choice of an adequate therapeutic policy, by improving the prognosis of the disease. The method of choice for diagnosing pulmonary mucormycosis is computed tomography that allows accurate determination of the location and extent of the lesion, the state of the lung parenchyma, and the presence of concomitant complications. The paper describes a clinical case of damage to the lung and skin in invasive mucormycosis in a 28-year-old woman with aplastic anemia. The case is of interest due to a larger number of immunocompromised patients, especially those susceptible to the disease.
Pengaruh Bahan Kalsium Oksida pada Waktu Pengikatan Pasta Beton Geopolimer dan Konvensional
Authors: Qomaruddin Mochammad , Umam Khotibul , Istianah Istianah , Adi Saputro Yayan , Purwanto Purwanto 
Published: September 2019

Pasta geopolimer merupakan pasta dengan bahan limbah fly ash sebagai binder dan pasta konvensional merupakan pasta yang menggunakan semen sebagai bahan utama binder. Substitusi penambahan bahan limbah pada penelitian ini bertujuan untuk komparasi antara pasta geopolimer dan pasta konvensional dengan beberapa variasi limbah. Metode yang digunakan dalam penelitian ini adalah eksperimental setting time dengan prosentase variasi perbandingan binder 100% FA : 0%, 90% : 10%, 80% : 20. Aktivator 1 : 2 (NaOH dan Na2SiO3) Molaritas yang dipakai yaitu 8M dan 12M. Proses Setting time (waktu pengikatan awal) yaitu saat pencampuran binder dengan air maupun aktivator kemudian penurunan jarum terjadi setelah waktu terjadi setiap 5 menit. Dari hasil setting time dengan perbandingan pasta konvensional dan pasta geopolimer menunjukan bahwa waktu ikat awal paling cepat terjadi pada pasta geopolimer 12M penambahan gypsum 20% yaitu selama 7 menit. untuk waktu ikat awal paling cepat dengan perbandingan pasta geopolimer 8M dan 12M terjadi pada pasta geopolimer 12M. Sedangkan pada untuk pengikatan akhir terjadi paling cepat pada pasta geopolimer 12M dengan penambahan gypsum 8M yaitu selama 15 menit.
Elbow Flexion Reanimation
Authors: Shah Neil V. , Kelly John J. , Patel Aakash M. , White Colin M. , Hausman Michael R. , Koehler Steven M. 
Published: September 2019

» Restoration of elbow flexion in the setting of brachial plexopathy is crucial and can be accomplished in a number of ways. Current options include non-free muscle transfers, including tendon, nerve, and pedicled flap transfers, and free functional muscle transfers, most frequently involving transfer of the gracilis muscle.» Currently, free functional muscle transfer is employed when all other options have been exhausted. Graft-related advantages include lack of functional deficits at the donor site, similar size of vascular structures of the gracilis to the thoracoacromial artery and cephalic vein, and contractile fibers running in parallel to the muscle’s course.» Evidence is limited when comparing various methods of elbow flexion reanimation, particularly when evaluating free functional muscle transfers and non-free muscle transfers against each other. However, current but limited evidence appears to demonstrate favorable functional outcomes with free functional muscle transfers, although prospective studies are needed to confirm these findings.
Variación morfológica en <i>Heterophrynus boterorum</i> (Arachnida: Amblypygi: Phrynidae)
Authors: Vasquez Palacios Sebastian , Chirivi Joya Daniel Andres , García Hernández Andrea Lorena , Mantilla Meluk Hugo , Torrez Carrera Jhon Deiber 
Published: September 2019

Se evaluó la variación morfológica de Heterophrynus boterorum con relación a su distribución geográfica, comparando poblaciones de la vertiente oriental y occidental de la cordillera Central y una población de la cordillera Oriental de los Andes, en los departamentos de Tolima y Quindío, Colombia. Mediante técnicas de estadística univariada y multivariada, (ACP, ANOVA y Kruskal-Wallis), se compararon poblaciones presentes en municipios de ambas vertientes y cordilleras. Se encontró variación entre poblaciones en 15 de 33 caracteres morfológicos examinados. La mayor variación se encontró en el tamaño de palpos, número de espinas y tubérculos. La población del municipio de Lérida se diferenció notablemente de las demás poblaciones del análisis. El resto de poblaciones formaron un grupo morfológico con amplia variabilidad, principalmente en tamaño. Heterophrynus boterorum podría considerarse como modelo de estudio para el efecto del gradiente ambiental y altitudinal de los Andes en la diversificación morfológica de los Amblypygi.
Evaluación rápida de Mamíferos en áreas de conservación de la corporación autónoma del departamento del Quindío, Colombia.
Authors: Vasquez Palacios Sebastian , Chica-Gálvis Carlos Andres , Mantilla-Meluk Hugo , Díaz-Giraldo Vanessa , Botero-Zuluaga Mariana , O. Montilla Sebastián 
Published: September 2019

Se presenta el listado de los mamíferos medianos y grandes registrados en 11 áreas de conservación del departamento del Quindío, Colombia. La fase de campo se desarrolló en cinco municipios, entre julio y diciembre del 2016, y el muestreo incluyó recorridos por transectos e instalación de cámaras trampa. Se confirma la presencia de 21 especies de mamíferos en las áreas estudiadas. Las áreas con mayor número de especies hacen parte de la Reserva Forestal Central o están cerca a otras áreas de conservación, situación que podría estar permitiendo la interconexión entre reservas por corredores biológicos. Cuatro de las especies registradas se encuentran bajo categoría de amenaza: Tapirus pinchaque (En Peligro), Aotus lemurinus, Leopardus tigrinus y Mazama rufina (Vulnerable). Se resalta la presencia de Leopardus pardalis como nuevo registro para el departamento.
La organización-empresa: ¿un sistema vivo? Aportes de la teoría de la complejidad y la filosofía ambiental a la teoría administrativa y organizacional
Authors: Arias-Pineda Andrés Alberto , Ramirez-Martinez Leonardo 
Published: September 2019

Rev.esc.adm.neg
La concepción de la organización-empresa como un sistema vivo, dinámico y caórdico, conformada y gestionada por cuerpos mundo-de-la-vida simbólico-biótico, emerge de preguntarse por los aportes qué hacen las teorías de la complejidad y la filosofía ambiental a las teorías administrativas y organizacionales; es decir por cuestionar la posibilidad de reconfigurar las lógicas administrativas, que se hallan en una crisis estructural, a partir de la perspectiva epistémica complejo-ambiental o por la necesidad de entender qué significa gestionar organizaciones sociales vivas. En otras palabras, surge como una propuesta para comprender el fenómeno administrativo-organizacional en tiempos de sociedad de organizaciones y crisis ambiental e implica comprender la organización social tipo taxis como un sistema social vivo que establece entramadas relaciones con su entorno, afectando el desarrollo de sus operaciones y procesos.
La vitalidad de estos sistemas deviene de sus redes informales, de su cultura organizacional, de la posibilidad de flexibilizar sus estructuras y sus procesos, y de su clausura referencial.
El texto se despliega en dos rutas de trabajo. El primer trayecto pretende comprender la relación entre los problemas civilizatorios actuales, y la institucionalización del pensamiento administrativo clásico en la sociedad. El segundo intenta aportar en la discusión epistémica en el campo de las Teorías Organizacionales y Administrativas, desde el lente teórico de las Teorías de la Complejidad y el Caos, y la Filosofía Ambiental.