bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Opiocephalus striatus Extract on Leptin, Adiponectin and COPD Assessment Test Scores on Stable COPD Patients Experiencing Muscle Wasting
Authors: Widiasari Komang Sri Rahayu , Djajalaksana Susanthy , Rasyid Harun Al 
Published: September 2019

Background: Muscle wasting is one of extrapulmonary manifestations that occur in 20-40% of patients with COPD as a result of an
imbalance of protein synthesis and degradation, where it is thought to be a consequence of chronic inflammation. One of the factor that affect
muscle wasting is nutritional factor. The purpose of this study is to prove that nutrition therapy can improve inflammation (measured by levels
of leptin, adiponectin) further improve muscle wasting and improve the quality of life of patients COPD with muscle wasting.
Method: The clinical study design is pre and post auto control quasi experimental in stable COPD patients with comorbid muscle wasting.
The experiment was conducted in Pulmonary Outpatient Clinic Dr. Saiful Anwar Hospital and Physiology Laboratory of Medical Faculty
Brawijaya University. Chronic obstructive pulmonary disease was diagnosed based on 2014 GOLD criteria. Muscle wasting was diagnosed
through examination of the BIA. Levels of leptin and adiponectin was measured using ELISA method, and quality of life was assessed
using CAT score. We measured BIA, Leptin, Adiponectin and CAT in 32 COPD patients with muscle wasting, before and after 12 weeks
supplementation of Opiocephalus striatus extract 3x1000mg/day.
Results: There were significant increased of BMI (p = 0.046), no significant increase of FFMI (p = 0506), a significant decrease in leptin
levels (p = 0.000) and a significant increase in adiponectin levels (p = 0.048) and improvement of quality of life (score CAT) (p = 0.000) ) after
administration of opiocephalus striatus extract for 12 weeks.
Conclusion: Suplementation of Opiocephalus striatus extract for 12 weeks can improve BMI, decrease levels of leptin and increase level
of adiponectin resulting in improvement of quality of life in stable COPD patients with muscle wasting.
André Diligent (1919-2002). Mise en perspective des apports des sept premières journées d’études (2012-2018)
Authors: Béthouart Bruno 
Published: September 2019

L’association des Amis d’André Diligent a décidé d’organiser entre 2012 et 2018 des journées d’études thématiques consacrées à cette personnalité roubaisienne au destin autant national que régional et local. Grâce aux responsables de la médiathèque de Roubaix où sont conservées les archives d’André Diligent, au directeur du Musée « La Piscine » qui porte son nom, au soutien de la municipalité, la mise en place de ces journées d’études a permis de traiter de questions relevant de ses diverses responsabilités. L’objet de cette contribution vise à mettre en exergue quelques éléments qui ont permis de renouveler la connaissance et la vision politique de celui qui, qualifié de « Candide du Sénat » par les médias nationaux, a été marqué par le destin tragique de son père, avocat comme lui.
Quand le canal se construit
Authors: Braeuner Hélène 
Published: September 2019

Pendant les dix années du chantier de creusement du canal de Suez sont produites des images et des textes qui interrogent sur les discours traditionnellement partagés autour d’une œuvre jugée utile, voire légitime et envisagée comme un idéal de modernité. Nombreux sont ceux qui applaudissent les progrès techniques apportés par les ingénieurs européens. Dans un imaginaire de tous les possibles qui s’enrichit de créations plastiques et poétiques chantant la réunion des deux mers, les visiteurs du chantier, qui ont remplacé les voyageurs suivant les traces de Moïse, interrogent peu la place de l’Orient tandis que l’Occident se félicite de féconder une terre « infertile ». Mais la région n’offre ni l’Orient ni la modernité complètement. Œuvres peintes et récits de voyage mettent en lumière ces deux réseaux d’attentes et de déceptions. Et ce sont les artistes, même ceux missionnés par la Compagnie universelle du canal de Suez, qui expriment souvent davantage une forme de résistance à la modernité, laquelle ne parvient guère à l’emporter face à ce qui est perçu comme l’immuable de l’Égypte.
L’imaginaire cinématographique de Port-Saïd
Authors: Mobarak Salma 
Published: September 2019

Cet article explore l’imaginaire de Port-Saïd dans le cinéma du canal de Suez, dont la naissance et le développement sont étroitement liés à l’histoire de ce dernier. Trois fictions cinématographiques emblématiques de Port-Saïd à l’écran illustrent le topos du voyage envisagé comme dimension structurelle de la ville-port. Itinéraire menant à une extraterritorialité et médiation entre sujets, territoires et cultures, le voyage est pris en charge par des genres, des formes et des motifs cinématographiques qui produisent un imaginaire spécifique de la ville. L’étude poursuit la manière dont le topos du voyage s’inscrit dans quatre figures principales (balnéaire, urbaine, portuaire et guerrière) qui composent l’imaginaire cinématographique de Port-Saïd.
La corvée lors du creusement de l’isthme
Authors: Farouk May 
Published: September 2019

Pratique ancestrale exercée depuis l’Antiquité, la corvée joua, lors du creusement du canal de Suez, un rôle fondamental que la légende dorée du canal – à bien des égards – tend à minimiser, sinon à occulter. De ce projet pharaonique qui révolutionna la navigation mondiale, une mémoire idéalisante retient, en effet, moins le sacrifice de milliers de fellahs mobilisés sur les chantiers que le génie diplomatique des principaux acteurs (Lesseps, Saïd pacha, Ismaïl pacha, la Compagnie du Canal...) vantant ainsi l’union sacrée des deux mers qui venait de sceller le mariage mythique de l’Orient et de l’Occident. Or, c’est précisément le revers de la médaille, à savoir l’envoi à la corvée de milliers d’ouvriers égyptiens dans des conditions très précaires que nous souhaitons examiner. Un premier détour par l’histoire nous permettra de cerner comment, dans le cadre du percement de l’isthme, la corvée devient un enjeu polémique et géopolitique de taille. Et ce, avant de démonter les rouages d’une guerre des discours qui s’acharne à légitimer la corvée ou au contraire à la condamner dans un élan humaniste qui dissimule mal sa duplicité. Pour illustrer ce processus d’instrumentalisation de la corvée dans le discours propagandiste de l’époque, nous retiendrons notamment les retentissements médiatiques provoqués par la note turque qui stipule, parmi les conditions à la poursuite du creusement, l’arrêt de la corvée sur les chantiers. Enfin, nous tenterons d’analyser comment, en empathie avec les souffrances endurées par les fellahs, des écrivains comme Edmond About dans Le fellah (1869) et Erckmann-Chatrian dans Souvenirs d’un ancien chef de chantier à l’isthme de Suez (1877) ont représenté ce drame humain.
Les subalternes peuvent rêver : Mary Sibande et la résistance des domestiques sud-africaines
Authors: Ibos Caroline 
Published: September 2019

Dans sa série de sculptures Long live the Dead Queen , l’artiste Mary Sibande représente les femmes de sa famille, travailleuses domestiques qui, comme de nombreuses femmes noires sud-africaines, ont servi des familles blanches. Si le corps des statues, moulé sur celui de l’artiste, semble réaliste, leurs costumes déploient les rêves de puissance qui ont permis aux ancêtres de Sibande de résister à l’oppression. Proposant une lecture politique de cette œuvre dans un contexte postcolonial, l’article se saisit du concept de subalternité, tel que, d’Antonio Gramsci à Gayatri Spivak, il fut élaboré dans la théorie critique pour saisir les « traces de résistance » (Gramsci), les « voix étouffées » (Spivak) ou les capacités d’action de groupes maintenus dans la subordination et sur lesquels pèse une présomption de passivité sociale.
The Effect of Portfolio Diversification for the Bursa Malaysia
Authors: Mohd Norsiman Nadia Nadira , Yakob Noor Azuddin , Jr Carl B. McGowan, 
Published: September 2019

This paper examines the effect of portfolio diversification for stocks listed on the Malaysian stock exchange. We determine the extent to which the unsystematic risk component can be reduced through diversification posited by Modern Portfolio Theory. Prices of randomly selected stocks were obtained from Yahoo! Finance for the five year period starting from January 2010 to March 2014. In order to analyze the robustness of the empirical results, three sets of portfolios were tested in this study and each set contained 55 stocks. The total sample of 165 stocks was chosen from different sectors that are listed under Bursa Malaysia. In addition, the three samples were tested for two type of differencing intervals, daily and weekly, to obtain more robust results. The empirical findings of the study show that increasing the number of stocks in the sample portfolio leads to decreasing standard deviation (unsystematic risk) the investment portfolio for Malaysia Stock Market stocks until each portfolio is well-diversified. The uniqueness in this study is that the empirical results show that, the level of data frequency significantly influences changes in stock portfolio size required to obtain optimal portfolio diversification. Using the daily differencing interval, 45 stocks are need to eliminate unsystematic risk and using the weekly differencing interval, only 35 stocks are required to obtain a well-diversified portfolio.
Methylmercury Determination in Fish by Direct Mercury Analyzer
Authors: Kim Tae-Hun , Cho Min-Ja , Lee Yongmin , Kim Ji Hui , Hwang Jeong-Yun , Lee Hye-Eun , Kim Sheen-Hee , Choi Jang-Duck , Kang Gil-Jin 
Published: September 2019

Abstract
Background: There are two methods for quantifying methylmercury (MeHg) in fish using GC–electron capture detection (ECD): AOAC INTERNATIONAL Official Method 988.11 and the Korean Food Code (KFC) method. Both of these methods consume a large amount of chemicals and require long pretreatment times because of several complicated MeHg extraction steps. Objective: In this study, a new method for the simple and rapid determination of MeHg in fish has been developed. The method is based on the investigation of oxygen combustion–gold amalgamation using a direct mercury analyzer (DMA) after the complete removal of MeHg by organic extraction and back-extraction to an aqueous medium. Methods: The DMA is suitable for the analysis of both solid and liquid materials and has a good detection limit. The developed method was validated by comparing the MeHg recoveries (%) of both certified reference materials and the market-purchased fish samples with the MeHg concentration obtained using the KFC method. Results: The following parameters pertaining to the developed method were established: detection limit, 1.02 μg/kg; LOQ, 3.09 μg/kg; linearity (r), 0.9998; range, 0.1–300 μg/kg; and recovery, 95–97%. Conclusions: Our method is a promising alternative by virtue of its much simpler and faster sample pretreatment procedure, with a MeHg recovery as high as that of the KFC method. Highlights: The developed method enables the simultaneous analysis of total Hg and MeHg with only DMA equipment.
Gastrointestinal Pathologies Recorded at the Felix Houphouet-boigny University Community Health Center from 2013 to 2017 (Abidjan - Ivory Coast)
Authors: N’gbesso N’gbesso Jean-Paul , Demedeiros Kanga , Ahoua Allou Aimé Constantin , Landry Arra A. Juli , Cisse Doumbia Mariamou , Mambey Serge , N’guessan Okoubo Née Nicaise A. 
Published: September 2019

Background: Gastrointestinal pathologies constitute a significant public health problem for the Ivory Coast, particularly for populations living under conditions of poor hygiene.
Aims: The purpose of this study is to evaluate the prevalence of gastrointestinal pathologies within the student body attending the Felix Houphouet-Boigny University Community Health Center.
Place and Duration of Study: The study was conducted in the university center of the university Felix Houphouet-Boigny de Cocody to the south of the Ivory Coast between January to February 2018.
Methodology: It consisted of a documentary investigation which was carried out by consulting the medical files of the patients.
Results: The results revealed that gastrointestinal pathologies constituted the third principal cause of affection in the students with 16% of the consultations. This study permitted to evaluate the level of prevalence of gastrointestinal pathologies of 2013 to 2017.
Conclusion: From this study, it was concluded that gastrointestinal pathology was a health problem for this student population.
Surgical Venous Cutdown for the Insertion of Totally Implantable Venous Access Devices
Authors: Tsukiyamam Naofumi , Shimomura Manabu , Toyota Kazuhiro , Karakuchi Nozomi , Ono Kosuke , Shishida Masayuki , Oishi Koichi , Miyamoto Kazuaki , Ikeda Masahiro , Sadamoto Seiji , Egi Hiroyuki , Ohdan Hideki , Takahashi Tadateru 
Published: September 2019

Purpose:Stable insertion of totally implantable venous access devices (TIVADs) is mandatory for the administration of chemotherapy and parenteral nutrition. Subclavian venipuncture is the most popular route; however, perioperative complications occur in up to 12% of patients. We inserted TIVADs by surgical venous cutdown of the cephalic vein at the deltopectoral groove with the intention of a safe and stable implantation.Methods:We implanted TIVADs in 318 consecutive patients (331 cases) from January 2011 to December 2015. We retrospectively analyzed short- and long-term treatment outcomes and risk factors for primary failure of implantation and removal due to catheter-related complications.Results:The aim of implantation was chemotherapy in 198 cases, nutrition in 92 cases, and frequent intravenous drip in 41 case. Surgical venous cutdown was performed in 321 of 331 cases (97%); primary failure occurred in 42 cases (13.1%). Short-term complications occurred in 4 cases (1.2%), and there were no serious complications, such as pneumothorax. In the analysis of risk factors for primary failure, aim of implantation (chemotherapy versus nutrition versus frequent intravenous drip) was the only risk factor (P = 0.02). Removals occurred in 35 cases (11.5%). In the analysis of risk factors for removal due to complications, presence of infectious disease was identified as the only significant risk factor (P &lt; 0.001).Conclusions:We confirmed the safety and efficacy of the cutdown method and clarified the risk factors for primary failure and removal. The cutdown method was safe and was not associated with serious complications; however, selective implantation was needed to achieve a high success rate.
Intrinsic mitotic activity supports the human salivary gland acinar cell population
Authors: Ingalls Matthew H. , Hollomon Andrew J. , Newlands Shawn D. , McDavid Andrew N. , Ovitt Catherine E. 
Published: September 2019

To develop treatments for salivary gland dysfunction, it is important to understand how human salivary glands are maintained under normal homeostasis. Previous data from our lab demonstrated that murine salivary acinar cells maintain the acinar cell population through self‐duplication under conditions of homeostasis, as well as after injury. Early studies suggested that human acinar cells are mitotically active, but the identity of the resultant daughter cells was not clear. Using markers of cell cycle activity and mitosis, as well as an ex vivo 5‐Ethynyl‐2´‐deoxyuridine assay, we show that human salivary gland acinar cells divide to generate daughter acinar cells. As in mouse, our data indicate that human salivary gland homeostasis is supported by the intrinsic mitotic capacity of acinar cells.
Improving treatment efficiency via photon optimizer (PO) MLC algorithm for synchronous single‐isocenter/multiple‐lesions VMAT lung SBRT
Authors: Sanford Lana , Pokhrel Damodar 
Published: September 2019

AbstractPurposeElderly patients with multiple primary or oligometastases (<5 lesions) lesions with associated co‐morbidities may not retain their treatment position for the traditional long SBRT treatment time with individual isocenters for each lesion. Treating multiple lesions synchronously using a single‐isocenter volumetric arc therapy (VMAT) plan would be more efficient with the use of the most recently adopted photon optimizer (PO) MLC algorithm and improve the patient comfort. Herein, we quantified the clinical performance of PO versus its predecessor progressive resolution optimizer (PRO) algorithm for single‐isocenter/multiple‐lesions VMAT lung SBRT.Materials and methodsFourteen patients with metastatic non‐small‐cell lung cancer lesions (two to five, both uni‐ and bilateral lungs) received a highly conformal single‐isocenter co/non‐coplanar VMAT (2–6 arcs) SBRT treatment plan. Patients were treated with a 6X‐FFF beam and Acuros algorithm with a single‐isocenter placed between/among the lesions, using PO for MLC optimization. Average isocenter to tumor distance was 5.5 ± 1.9 cm. Mean combined PTV derived from 4D‐CT scans was 38.7 ± 22.7 cc. Doses were 54 Gy/50 Gy in 3/5 fractions prescribed to 70%–80% isodose line so that at least 95% of the PTV receives 100% of prescribed dose. Plans were re‐optimized using PRO algorithm. Plans were compared via ROTG‐0915 protocol criteria for target conformity, heterogeneity and gradient indices, and dose to organs‐at‐risk (OAR). Additionally, total number of monitor units (MU), modulation factor (MF) and beam‐on time were compared.ResultsAll plans met SBRT protocol requirements for target coverage and OAR doses. Comparison of target coverage and dose to the OAR showed no statistical significance between the two plans. PO had 1042 ± 753 (P < 0.001) less MU than PRO resulting in a beam‐on time of about 0.75 ± 0.5 min (P < 0.001) less, on average. For similar dose distribution, a significant reduction of beam delivery complexity was observed with PO (average MF = 3.7 ± 0.7) vs PRO MLC algorithm (average MF = 4.4 ± 1.3) (P < 0.001).ConclusionsPO MLC algorithm improved treatment efficiency without compromising plan quality when compared to PRO algorithm for single‐isocenter/multi‐lesions VMAT lung SBRT. Shorter beam‐on time can potentially reduce intrafraction motion errors and improve patient compliance. PO MLC algorithm is recommended for future clinical lung SBRT plan optimization.
A Virus‐Mimicking pH‐Responsive Acetalated Dextran‐Based Membrane‐Active Polymeric Nanoparticle for Intracellular Delivery of Antitumor Therapeutics
Authors: Wannasarit Saowanee , Wang Shiqi , Figueiredo Patrícia , Trujillo Claudia , Eburnea Francesca , Simón‐Gracia Lorena , Correia Alexandra , Ding Yaping , Teesalu Tambet , Liu Dongfei , Wiwattanapatapee Ruedeekorn , Santos Hélder A. , Li Wei 
Published: September 2019

AbstractAchieving cellular internalization and endosomal escape remains a major challenge for many antitumor therapeutics, especially macromolecular drugs. Viral drug carriers are reported for efficient intracellular delivery, but with limited choices of payloads. In this study, a novel polymeric nanoparticle (ADMAP) is developed, resembling the structure and functional features of a virus. ADMAP is synthesized by grafting endosomolytic poly(lauryl methacrylate‐co‐methacrylic acid) on acetalated dextran. The endosomolytic polymer mimics the capsid protein for endosomal escape, and acetalated dextran resembles the viral core for accommodating payloads. After polymer synthesis, the subsequent controlled nanoprecipitation on a microfluidic device yields uniform nanoparticles with high encapsulation efficiency. At late endosomal pH (5.0), the ADMAP particles successfully destabilize endosomal membranes and release the drug payloads synergistically, resulting in a greater therapeutic efficacy compared with that of free anticancer drugs. Further conjugation of a tumor‐penetrating peptide enhances the antitumor efficacy toward 3D spheroids and finally leads to spheroid disintegration. The unique structure along with the synergistic endosomal escape and drug release make ADMAP nanoparticles favorable for intracellular delivery of antitumor therapeutics.
Unlocking the Potential of Disordered Rocksalts for Aqueous Zinc‐Ion Batteries
Authors: Ding Junwei , Du Zhiguo , Li Bin , Wang Lizhen , Wang Shiwen , Gong Yongji , Yang Shubin 
Published: September 2019

AbstractOwing to the intense charge repulsion of multivalent ions and intrinsic slugggish kenetics, vast and fast storage of zinc ions into electrode materials has remained unattainable. Here, an efficient strategy to unlock the electrochemical activity of rocksalt vanadium oxynitride is developed via the substitution of low‐valent oxygen for high‐valent nitrogen, forming disordered rocksalt with abundant vacancies/defects due to the charge‐compensating function. Unexpectedly, the disordered rocksalt not only provides plentiful active sites for zinc ions but is also beneficial for the rapid diffusion of zinc ions, owing to the large presence of vacancies/defects in the matrix. Hence, a very high reversible capacity (603 mAh g−1, 0.2C) and high rate capability (124 mAh g−1at 600C) are achieved for zinc storage. This should open a new and efficient avenue for the design of electrode materials with both high energy and power densities for aqueous zinc‐ion batteries.
Uniform and Size‐Controlled Synthesis of Pt Nanoparticle Catalyst by Fluidized Bed Reactor Atomic Layer Deposition for PEMFCs
Authors: Lee Woo‐Jae , Bera Susanta , Shin Heon‐Cheol , Hong Woong‐Pyo , Oh Seung‐Jeong , Wan Zhixin , Kwon Se‐Hun 
Published: September 2019

AbstractPt nanoparticles (NPs) on a carbon support (Pt/C) are deposited by a simple fluidized bed reactor atomic layer deposition (FBR‐ALD) technique. The growth characteristics of the Pt NPs are investigated as a function of ALD cycles from 5 to 30 cycles. The excellent characteristics of FBR‐ALD offer highly dispersed and dense Pt particles with a size of ≈1 nm at low ALD cycles (5 cycles). However, as the number of ALD cycles increases above 5, the NPs increase in size and agglomerate due to preferential growth of incoming Pt NPs on previously deposited Pt surfaces. An electrochemical study shows that low ALD cycles (5 cycles) for the Pt/C catalyst result in a high electrochemical active surface area (ECSA) (114.67 m2 g−1). With increasing the number of cycles, ECSA is found to decrease, but still apparently higher than that of commercial Pt catalyst with the similar Pt wt% loading. Finally, ALD Pt/C catalysts with various cycles are applied to fuel cell testing for power generation. The electrode prepared with 20 ALD cycles of the Pt/C catalyst shows the best fuel cell performance (1.58 A cm−2 at 0.6 V) due to an adequate combination of activity and mass transfer characteristics of the electrode.