bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnancy rate after fixed‐time transfer of cryopreserved embryos collected by non‐surgical route in Lacaune sheep
Authors: Figueira Lucas Machado , Alves Nadja Gomes , Batista Ribrio Ivan Tavares Pereira , Brair Viviane Lopes , Lima Renato Ribeiro , Oliveira Maria Emilia Franco , Fonseca Jeferson Ferreira , Souza‐Fabjan Joanna Maria Gonçalves 
Published: August 2019

AbstractThis study investigated the feasibility of applying fixed‐time (cryopreserved) embryo transfer in ewes. Embryos (n = 106) were non‐surgically recovered from superovulated donors (n = 39) on day 6–7 after oestrus. Straws containing one or two embryos (morulae and/or blastocysts) subjected to either slow freezing (SF, n = 62) or vitrification (VT, n = 44) were randomly used within fixed‐time embryo transfer on Day 8.5. Recipient ewes were nulliparous (n = 58) bearing corpora lutea after synchronous oestrous induction protocol. The pregnancy rate was higher (p = .03) in SF (39.4%) than VT (16.9%) and survival rate tended (p = .08) to be higher in SF than in VT (25.8% vs. 15.9%). Lambing rates were similar (p = .13) between SF (20.9%) and VT (15.9%). Embryos recovered by non‐surgical route after cervical dilation treatment and later cryopreserved by either slow freezing or vitrification produced reasonable pregnancy rates after FTET.
Improved in vitro quality of stored red blood cells upon oxygen reduction prior to riboflavin/UV light treatment of whole blood
Authors: Schubert Peter , Culibrk Brankica , Chen Deborah , Serrano Katherine , Levin Elena , Chen Zhongming , Zoescher Peter , Goodrich Raymond P. , Yoshida Tatsuro , Devine Dana V. 
Published: August 2019

BACKGROUNDThe application of riboflavin/UV‐based pathogen inactivation (PI) to whole blood (WB) is currently limited by its negative impact on red blood cell (RBC) quality. The generation of reactive oxidative species in RBC products contributes to increased hemolysis. This study evaluated the impact of deoxygenation of WB prior to riboflavin/UV light treatment versus deoxygenation of RBC concentrates after PI treatment by monitoring RBC in vitro quality parameters.STUDY DESIGN AND METHODSSix ABO‐matched WB units were pooled and split. Within three pairs, one unit was treated with riboflavin/UV light while the other was kept as an untreated control prior to manufacture into red cell concentrates (RCCs). The first pair (Cntr; Cntr‐PI) served as the normoxic controls. Deoxygenation was performed at the RCC level for the second pair (RCCdeox; PI‐RCCdeox), and at the WB level of the third pair (WBdeox; WBdeox‐PI). In vitro qualities of the respective RBC units were assessed throughout storage.RESULTSThe data for the Cntr and Cntr‐PI units were comparable to previous reports. The PI‐RCCdeox units exhibited worse in vitro quality for most parameters tested compared to Cntr‐PI and WBdeox‐PI units throughout storage. Hemolysis and microvesicle release was significantly (p < 0.05) higher on Days 21 and 42 in Cntr‐PI units compared to WBdeox‐PI units.CONCLUSIONWB deoxygenation may help to decrease the accelerated deterioration in RCC in vitro quality caused by treatment with riboflavin/UV light. Treatment of WB under reduced oxygen levels needs to be assessed for PI effectiveness.
Jaccoud’s arthropathy in SLE: findings from a Latin American multiethnic population
Authors: Quintana Rosana , Pons-Estel Guillermo , Roberts Karen , Sacnún Monica , Berbotto Guillermo , Garcia Mercedes A , Saurit Veronica , Barile-Fabris Leonor , Acevedo-Vazquez Eduardo M , Tavares Brenol João C , Sato Emilia I , Iglesias Antonio , Uribe Oscar , Alarcon Graciela , Pons-Estel Bernardo A 
Published: August 2019

ObjectiveTo compare the clinical, laboratory and outcome features of SLE patients with and without Jaccoud’s arthropathy (JA) from theGrupo Latino Americano De Estudio del Lupus(GLADEL) cohort.Methods1480 patients with SLE [(34 centres, 9 Latin American countries with a recent diagnosis (≤2 years)] constitute the GLADEL cohort. JA was defined as reducible deformity of the metacarpophalangeal axis, without radiographic erosions at any time. Within this cohort, a nested case–control study was carried out. Control was matched for age, gender and centre in a 1:3 proportion. The variables included were: sociodemographic, clinical and immunological features, disease activity, damage and mortality. Comparisons were performed with Wilcoxon and χ2tests for continuous and categorical variables, respectively. ORs and 95% CIs and Kaplan-Meier survival curve were estimated.ResultsOf 1480 patients, 17 (1.1%) JA patients were identified; 16 (94.1%) of them were women, mean age: 31.0 years (SD 12.0). Five (29.4%) patients presented JA at SLE diagnosis and 12 (70.6%) after. The median follow-up time and all disease features were comparable in both groups except for a higher frequency of pneumonitis in the patients with JA [4 (23.5) vs 1 (2.0); p=0.012; (OR: 15.4; 95% CI 1.6 to 149.6)]. The SLE disease activity index, Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage Index and the Kaplan-Meier survival curve were similar in both groups.ConclusionJA may tend to appear early in the course of SLE; it seems not to have an impact on disease activity, damage accrual or in survival.
Family satisfaction in the trauma and surgical intensive care unit: another important quality measure
Authors: Maxim Tom , Alvarez Agustin , Hojberg Yvonne , Antoku Derek , Moneme Chioma , Singleton Andrew , Park Caroline , Matsushima Kazuhide 
Published: August 2019

BackgroundA growing body of research has explored patient satisfaction as one of the healthcare quality measures. To date, scarce data are available regarding family experience in the trauma and surgical intensive care unit (TSICU). The purpose of this study was to describe and analyze the results of a family satisfaction survey in the TSICU.MethodsFamily members of patients at a level 1 trauma center were invited to participate in this study after 72 hours of intensive care unit stay. Participants completed a modified version of the Family Satisfaction in the Intensive Care Unit questionnaire, a validated survey measuring family satisfaction with care and decision-making. Data collection spanned from April 2016 to July 2017. Patient characteristics were compiled from the medical record. Quantitative analysis was performed using a 5-point Likert score, converted to a scale of 0 (poor) to 100 (excellent).ResultsThe overall response rate was 78.6%. Of the 103 family members for 88 patients, most were young (median age: 41 years) and female (75%). Language fluency was 44.6% English-only, 31.7% Spanish-only, and 23.8% bilingual. Mean summary family satisfaction scores (±SD) were 80.6±26.4 for satisfaction with care, 79.3±27.1 for satisfaction with decision-making, and 80.1±26.7 for total satisfaction. Respondents were less satisfied with the frequency of communication with physicians (70.7±27.4) and language translation (73.2±31.2).DiscussionOverall family satisfaction with the care provided to patients in the TSICU is high, although opportunities for improvement were noted in the frequency of communication between physicians and family and language translation services. Further quality improvement projects are warranted.Level of evidenceCare management study: level V.
Atypical profile of aortic injury associated with blunt trauma in the metropolitan area of Japan
Authors: Mori Shusuke , Ai Tomohiko , Otomo Yasuhiro 
Published: August 2019

BackgroundAortic injury caused by blunt trauma is a critical medical condition that requires extraordinary caution in the treatment. It is often caused by direct hit and high-speed deceleration in motor vehicle accidents. We reviewed and analysed the cases of aortic injury that referred to our institution located in the midst of the metropolitan area of Tokyo, Japan.MethodsWe retrospectively reviewed the blunt trauma cases transferred to Tokyo Medical and Dental University Hospital in the past 10 years. All cases with aortic injury were analyzed regardless of the AIS scores. Results: Between 2007 and 2017, a total of 3500 blunt trauma cases were transferred. Nineteen cases showed aortic injuries associated with blunt trauma (Age: 63.5±15.6 y.o.; 15 males). Thirteen patients were injured by fall, four patients were senior pedestrians hit by cars, one was injured while riding a motor bike, and one was hit by a train. A total of 11 cases presented a cardiopulmonary arrest on arrival; 8 severe aortic injuries, 1 cardiac rupture; and 2 multiple injuries. Eight cases were alive on arrival; 3 Stanford type A aortic dissections, 3 Stanford type B aortic dissections, and 2 aortic ruptures. Two cases of Stanford type A dissection underwent emergency repairs, whereas all 3 type B dissections went on a good course with conservative treatment.ConclusionsAortic injury caused by blunt trauma seems to be rare in a metropolitan area in Japan. In addition, the leading cause in our cases was fall, which might be a rare cause of aortic injuries in the other countries. Our observation might be a manifestation of population aging.
Barriers to and facilitators of a screening procedure for PTSD risk in a level I trauma center
Authors: McBain Sacha A , Sexton Kevin W , Palmer Brooke E , Landes Sara J 
Published: August 2019

BackgroundPatients admitted to the hospital after an injury are at a greater risk for developing post-traumatic stress disorder (PTSD) due to the nature of the injury and the traumatic nature of necessary medical interventions. Many level I trauma centers have yet to implement screening protocols for PTSD risk. The goal of the study was to characterize the barriers to and facilitators of implementation of a screening procedure for PTSD risk in a level I trauma center.MethodsWe conducted semistructured qualitative interviews with multidisciplinary academic medical center stakeholders (N=8) including those with clinical, research, teaching, and administrative roles within an urban academic medical center’s Department of Surgery, Division of Acute Care Surgery. We analyzed the qualitative data using summative template analysis to abstract data related to participants’ opinions about implementation of a screener for PTSD.ResultsParticipants’ general perception of screening for PTSD risk after injury was positive. Identified challenges to implementation included timing of screening, time burden, care coordination, addressing patients with traumatic brain injury or an altered mental status, and ensuring appropriate care after screening. Reported facilitators included existing psychosocial screening tools and protocols that would support inclusion of a PTSD screener, a patient-centered culture that would facilitate buy-in from providers, a guideline-driven culture, and a commitment to continuity of care.ConclusionsThis study offers concrete preliminary information on barriers to and facilitators of PTSD screening that can be used to inform planning of implementation efforts within a trauma center.Level of evidenceLevel V, qualitative.
Soil nitrous oxide emissions associated with conversion of forage grass to annual crop receiving annual application of pig manure
Authors: Adelekun Mayowa , Akinremi Olalekan , Tenuta Mario , Nikièma Paligwendé 
Published: August 2019

The disruptive land-use change during forage grass conversion to annual crop can be critical for determining nitrous oxide (N2O) emissions, but this is an understudied period. We measured soil N2O fluxes (using closed static vented chambers) together with potential environmental drivers of these fluxes from liquid pig manure (LPM) and solid pig manure (SPM) applied to an annual crop (ANN) and perennial forages (FPP) that was converted to annual crop. Unamended plots were used as a control (CON). The results showed that in 2013, average soil nitrate-N was significantly higher on the recently converted FPP (ranging from 19 to 83 mg N kg−1) than the continuous ANN plots (from 16 to 35 mg N kg−1). The recently converted perennial forage system produced three times greater N2O than the continuous annual system, which is likely a result of accelerated N mineralization from the accumulated soil organic matter (over 4 yr) and grass residues of the recently killed forage grasses. However, during the second year of the study when the FPP plots were reseeded to perennial grasses, the system emitted 30% less N2O than the ANN system. These results suggest that including perennial forage grass in rotation with annual crops can provide N-saving and climate change mitigation benefits; however, some of the N stored in the soil would be lost when the perennial grass plots are cultivated to grow annual crops.
Impact of deficit irrigation and addition of biochar and polymer on soil salinity and tomato productivity
Authors: Alkhasha Arafat , Al-Omran Abdulrasoul , Louki Ibrahim 
Published: August 2019

The aim of this study is to investigate impact of soil amendments (4% biochar, 0.4% polymer, and a combination of them) on soil moisture and salinity distribution, tomato yield, and water-use efficiency (WUE). Open-field experiments were conducted during two successive growing seasons in 2017 and 2018. The experiment consisted of three levels of irrigation treatments: 100%, 80%, and 60% of crop evapotranspiration (ETc); and two different water qualities: fresh 0.9 dS m−1 and saline electrical conductivity 3.6 dS m−1. Results revealed that at 100% of ETc, soil water distribution increased by 12.94%, 37.87%, and 42.21% at depths 0–15, 15–30, and 30–45 cm, with the addition of biochar, respectively, compared with control at same depths under freshwater, but the addition of polymer was increased by 6.35%, 16.56%, and 16.37%, respectively. While combination treatments increased by 15.70%, 24.80%, and 41.26%, at the depths aforementioned. Salt concentration was increased by 59.10% with biochar, whereas decreasing by 7.19% and 57.63% with polymer and mixture treatments, respectively. The results also showed that biochar and mixture treatments improved yield compared with the polymer and control, whereas saline water decreased the yield compared with freshwater. With deficit irrigation, WUE was increased by 28.54%, 40.98%, and 68.93% at 100%, 80%, and 60% of ETc, respectively, indicating it could be used as an irrigation management strategy under arid and semiarid field conditions.
Investigation of the synthesis of the unknown superheavy nuclei 309,312126
Authors: Nhan Hao T. V. , Duy N. N. , Chae K. Y. , Quang Hung N. , Nhu Le N. 
Published: August 2019

In this paper, we applied the method developed by Santhosh and Safoora in [Phys. Rev. C 94 (2016) 024623; 95 (2017) 064611] to theoretically investigate the fusion, evaporation-residue (ER) and fission cross-sections of the synthesis of the unknown superheavy [Formula: see text]126 nuclei produced by using the [Formula: see text]Ni + [Formula: see text]Cf and [Formula: see text]Zn + [Formula: see text]Cm combinations. The charge asymmetry, mass asymmetry and fissility of the DiNuclear System (DNS) in the synthesis of the mentioned combinations are also estimated. The calculated results show that the ER cross-sections for the synthesis of the [Formula: see text]126 nuclei are predicted to be much less than 1.0[Formula: see text]fb. In particular, it has been found that there may exist a valley of the ER cross-sections in the synthesis of a superheavy [Formula: see text] element, which produces the [Formula: see text]126 isotope. Subsequently, a model for the mass dependence of the ER cross-section in the synthesis of the [Formula: see text]126 isotopes has been proposed for the first time. On the other hand, the quasi-fission process strongly dominates over the fusion in the two concerned interacting systems. The present results, together with those reported in the previous studies, indicate that the investigated projectile–target combinations are not capable for the synthesis of the [Formula: see text]126 isotopes due to tiny fusion cross-sections (about 2–3[Formula: see text]zb), which go beyond the limitations of available facilities. Further studies are thus recommended to search for alternative interacting systems. In conclusion, this work provides useful information for the synthesis of the gap isotopes [Formula: see text]126, which have not been well studied up to date.
The Indenoisoquinoline TOP1 Inhibitors Selectively Target Homologous Recombination-Deficient and Schlafen 11-Positive Cancer Cells and Synergize with Olaparib
Authors: Marzi Laetitia , Szabova Ludmila , Gordon Melanie , Weaver Ohler Zoe , Sharan Shyam K. , Beshiri Michael L. , Etemadi Moudjib , Murai Junko , Kelly Kathleen , Pommier Yves 
Published: August 2019

Abstract

Purpose:
Irinotecan and topotecan are used to treat a variety of different cancers. However, they have limitations, including chemical instability and severe side effects. To overcome these limitations, we developed the clinical indenoisoquinolines: LMP400 (indotecan), LMP776 (indimitecan), and LMP744. The purpose of the study is to build the molecular rationale for phase II clinical trials.

Experimental Design:
CellMinerCDB (http://discover.nci.nih.gov/cellminercdb) was used to mine the cancer cell lines genomic databases. The causality of Schlafen11 (SLFN11) was validated in isogenic cell lines. Because topoisomerase I (TOP1)-mediated replication DNA damage is repaired by homologous recombination (HR), we tested the “synthetic lethality” of HR-deficient (HRD) cells. Survival and cell-cycle alterations were performed after drug treatments in isogenic DT40, DLD1, and OVCAR cell lines with BRCA1, BRCA2, or PALB2 deficiencies and in organoids cultured from prostate cancer patient-derived xenografts with BRCA2 loss. We also used an ovarian orthotopic allograft model with BRCA1 loss to validate the efficacy of LMP400 and olaparib combination.

Results:
CellMinerCDB reveals that SLFN11, which kills cells undergoing replicative stress, is a dominant drug determinant to the clinical indenoisoquinolines. In addition, BRCA1-, BRCA2-, and PALB2-deficient cells were hypersensitive to the indenoisoquinolines. All 3 clinical indenoisoquinolines were also synergistic with olaparib, especially in the HRD cells. The synergy between LMP400 and olaparib was confirmed in the orthotopic allograft model harboring BRCA1 loss.

Conclusions:
Our results provide a rationale for molecularly designed clinical trials with the indenoisoquinolines as single agents and in combination with PARP inhibitors in HRD cancers expressing SLFN11.
Targeting RNA Polymerase I with Hernandonine Inhibits Ribosomal RNA Synthesis and Tumor Cell Growth
Authors: Chen Yen-Ting , Chen Jih-Jung , Wang Hsiang-Tsui 
Published: August 2019

Abstract

RNA polymerase I (RNA Pol. I) activity is consistently expanded in multiplying cells to continue the expanded interest for ribosome generation and protein synthesis, which are fundamental for cell development and division. Thus, selective inhibitors of RNA Pol. I may offer a general helpful intends to block cancer cell multiplication. Hernandonine, isolated from the root wood of Hernandia nymphaeifolia, causes rearrangement of nucleolar proteins consistent with segregation of the nucleolus, a hallmark of RNA Pol. I transcription stress. Furthermore, the compound destabilizes RPA194, the large catalytic protein of RNA Pol. I, in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. Finally, hernandonine induces cellular apoptosis through a p53-dependent or p53-independent process in solid tumor cell lines. These outcomes feature the prevailing effect of RNA Pol. I transcription stress on apoptosis pathway initiation and present a synthetically novel and significant molecule that represses RNA Pol. I, making it a potential objective for malignancy treatment.

Implications:
Our findings position hernandonine as a potential, particular, and orally administered cancer treatment agent appropriate for use in investigational clinical trials.
The Role of Encoding Strategy in the Memory for Expectation-Violating Concepts
Authors: Porubanova Michaela 
Published: August 2019

AbstractMinimal counterintuitiveness and its automatic processing has been suggested as the explanation of persistence and transmission of cultural ideas. This purported automatic processing remains relatively unexplored. We manipulated encoding strategy to assess the persistence of memory for different types of expectation violation. Participants viewed concepts including two types of expectation violation (schema-level or domain-level) or no violation under three different encoding conditions: in the shallow condition participants focused on the perceptual attributes of the concepts, a deep condition probed their semantic meaning, and intentional remembering condition. Participants’ recall was tested immediately as well as 2 weeks later. Our findings showed the greatest memory enhancement for schema-level violations regardless of the encoding condition, while the memory for domain-level violations improved over time. These results suggest two distinct memory patterns for different types of violations, and illustrate the importance of elaborative processes in memory consolidation especially for violations to our expectations.
How Prone are Bulgarians to Heuristics and Biases? Implications for Studying Rationality across Cultures
Authors: Rachev Nikolay R. , Petkova Miglena 
Published: August 2019

AbstractDual-processes theories of cognition implicitly assume universality of the human mind. However, research has shown that large-scale differences exist in thinking styles across cultures. Thereby, the universality of the effects found in Western samples remains an open empirical question. Here, we explored whether effects predicted by prospect theory, such as the framing effect, would be observed in a sample of 312 Bulgarian students. Overall, the size of the framing effect was smaller than in the original studies. Most notably, we failed to reproduce the framing effect in the famous Asian Disease problem, using a rating response format. In a between-subjects design, decision- making performance was completely independent of university admission grades. We propose that studying the size of the effects across cultures is needed in order to establish the effects’ level of universality. More broadly, we suggest ways in which knowledge of cultural settings can help elaborate or test dual-process predictions.
The Aztec Gods in Blended-Space: a Cognitive Approach to Ritual Time
Authors: Dehouve Danièle 
Published: August 2019

AbstractBy applying diverse approaches to study the Aztec gods, light can be shed on different aspects of their personalities. In this article the cognitive theory of conceptual blending, developed by Fauconnier and Turner, is applied. In this perspective the functioning of the human mind is viewed as being grounded on the constant blending of mental spaces, a process that, in turn, makes new mental spaces emerge. After briefly reviewing the attempts to apply this theory to the ritual domain in general, I consider two types of Aztec rituals, one dedicated to the rain god Tlaloc, and the other to Xochiquetzal, the goddess of seduction. I show the importance of the compression of time in the blending process that condenses three moments: mythical time, ritual time and the immediate future. The capability of the gods to subvert the lineal passage of time and to compress past, present and future stands out as a one of the chief characteristics highlighting the advantages found by applying Blending-Theory.