bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of allograft bone using titanium mesh in the posterior-only surgical treatment of thoracic and thoracolumbar spinal tuberculosis
Authors: Wang Bingjin , Hua Wenbin , Ke Wencan , Zhang Yukun , Zeng Xianlin , Yang Cao 
Published: September 2019

Abstract
Background The bony fusion of allograft bone using titanium mesh in the posterior-only surgical treatment of thoracic and thoracolumbar spinal tuberculosis has not been explained in detail. We aimed to analyze the efficacy of bony fusion of allograft bone using titanium mesh in the posterior-only surgical treatment of thoracic and thoracolumbar spinal tuberculosis.Methods We treated 32 thoracic or thoracolumbar tuberculosis patients by one-stage posterior debridement, allograft bone graft using titanium mesh, posterior instrumentation, and fusion from May 2011 to September 2015. The American Spinal Injury Association neurological classification, visual analog scale, and Oswestry disability index scores were analyzed preoperatively, postoperatively, and at final follow-up. The Cobb angles were recorded to evaluate the kyphosis correction and the loss of correction. The bony fusion was evaluated by X-ray and computed tomography images, and the bony fusion classifications were recorded.Results All patients had pain relief. The erythrocyte sedimentation rate, C-response protein, and hepatorenal function were normal at final follow-up. The American Spinal Injury Association neurological classification, visual analog scale, and Oswestry disability index scores were improved in all the patients. All patients achieved bone fusion. Twenty-eight patients achieved complete fusion (Grade I), whereas only four patients achieved partial fusion (Grade II). The preoperative Cobb angle was 33.6±9.3°. The Cobb angle was reduced to 10.6±2.6° postoperatively and was found to be 11.4±3.1° at the final follow-up. The mean angle correction was 23.0±8.9°, and the correction rate was 66.2±12.2%. The mean angle lost was 0.8±0.9°, and the lost rate was 5.8±5.4% at the final follow-up.Conclusions Allograft bone using titanium mesh in the posterior-only surgical treatment is effective for patients with thoracic and thoracolumbar spinal tuberculosis. It can correct kyphosis, and most patients can achieve complete bony fusion.
Effects of nasal continuous positive airway pressure on cerebral hemodynamics in preterm infants
Authors: ZHOU Han , ZHAO Youyan , CHENG Rui , HOU Xuewen , Qiu Jie 
Published: September 2019

Abstract
Background To evaluate effects of different positive end-expiratory pressure (PEEP) levels on cerebral hemodynamics of premature infants when using nasal continuous positive airway pressure (nCPAP) during the first 3 days of life. Methods Forty-four preterm infants treated with nCPAP were divided into very preterm infant group (gestational age 1 (GA1) group, GA<32 weeks, n=24) and moderate and late preterm group (GA2 group, GA 32-37 weeks, n=20). During the monitoring process, the PEEP was set at 4→6→8→4 cmH 2 O and cerebral hemodynamics was assessed by near-infrared spectroscopy (NIRS). Life signs, peripheral oxygen saturation (SpO 2 ) and transcutaneous carbon dioxide pressure (TcPCO 2 ) were recorded at the same time. Results Tissue oxygenation index (TOI), cerebral blood volume (△CBV) and the difference between oxygenated hemoglobin (△HbO 2 ) and deoxygenated hemoglobin (△HHb) (△HbD) were all significantly positive correlated with gestational and postnatal age and the fluctuation of GA1 group was greater. △CBV and △HbD were also significantly positive correlated with TcPCO 2 . PEEP of 4-8 cmH 2 O had no significant influence on cerebral hemodynamics, life signs, SpO 2 or TcPCO 2 . Conclusions No significant differences were observed in cerebral hemodynamics when the PEEP was set from 4 to 8 cmH 2 O. These findings confirmed the safety and reliability of nCPAP at regular pressure levels to the nervous system of preterm infants.
Mainstreamed Genetic Testing of Breast Cancer Patients in Two Hospitals in South Eastern Norway
Authors: Grindedal Eli Marie , Jørgensen Kjersti , Olsson Pernilla , Gravdehaug Berit , Lurås Hilde , Norum Jan , Schlichting Ellen , Vamre Tone , Wangensteen Teresia , Heramb Cecilie , Mæhle Lovise 
Published: September 2019

Abstract
Background: Identification of a BRCA mutation in a breast cancer patient provides critical information both for treatment decisions and for prevention of new cancers. In South Eastern Norway, genetic testing of the BRCA genes has been mainstreamed into breast cancer care. Testing is offered directly to the patients by the surgeon or oncologist if they fulfill national criteria. The purpose of this study was to investigate to what extent BC patients who fulfill these criteria are offered testing. Methods: Three hundred and sixty one BC patients diagnosed during the first half of 2016 and 2017 at one university and one regional hospital in South Eastern Norway were included in the study. Data were collected on whether the patients fulfilled the criteria, whether they had been offered testing and if they had accepted testing. Results: For the two hospitals combined, 75% of BC patients who fulfilled the criteria were offered testing. The numbers were 63% at the regional hospital and 90% at the university hospital. Fifty two percent of the patients who were not offered testing even though they fulfilled the criteria and were younger than 50 years at time of diagnosis. As many as 95% of the patients who were offered testing, wanted to be tested. Conclusions: The majority of patients who fulfilled the criteria were offered testing. However, there were differences in rates of testing between the hospitals that affected all groups of patients. This indicates that diagnostic genetic testing is not equally available to all BC patients. We suggest that efforts should be made to raise awareness of and improve routines for genetic testing of BC patients in Norway.
Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)
Authors: Chen Lulu , Yuan Mingzhen , Sun Lu , Wang Yuelin , Chen Youxin 
Published: September 2019

Abstract
Purpose: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients. Methods: Forty-seven unilateral BRVO patients were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes and fellow eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal density 300 (FD-300) were measured. Results: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes ( P <0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P <0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes ( P <0.05). Conclusions: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Key words: optical coherence tomography angiography, retinal vasculature, foveal avascular zone, radial peripapillary capillary, branch retinal vein occlusion
Efficacy and safety of calcitonin-gene-related peptide binding monoclonal antibodies for the preventive treatment of episodic migraine – An updated systematic review and meta-analysis
Authors: Deng Hong , Li Gai-gai , Nie Hao , Feng Yang-yang , Guo Guang-yu , Guo Wen-liang , tang zhouping 
Published: September 2019

Abstract
Background Migraine is one of the most common neurological disorders that leads to disabilities. However, the conventional drug therapy for migraine is unsatisfactory. Therefore, this meta-analysis aimed to evaluate the efficacy and safety of calcitonin-gene-related peptide binding monoclonal antibody (CGRP mAb) for the preventive treatment of episodic migraine, and provide high-quality clinical evidence for migraine therapy.Methods A systematic electronic database search was conducted to identify the potentially relevant studies. Two independent authors performed data extraction and quality appraisal. Mean difference (MD) and risk ratio (RR) were pooled for continuous and dichotomous data, respectively. The significance levels, weighted effect sizes and homogeneity of variance were calculated.Results Eleven high-quality randomized control trials that collectively included 4402 patients were included in this meta-analysis. Compared to placebo group, CGRP mAb therapy resulted in a reduction of monthly migraine days [weighted mean difference (WMD) = −1.44, 95% CI = (−1.68,−1.19)] and acute migraine-specific medication days [WMD = −1.28, 95% CI = (−1.66,−0.90)], with an improvement in 50% responder rate [RR = 1.51, 95% CI =(1.37,1.66)]. In addition, the adverse events (AEs) and treatment withdrawal rates due to AEs were not significantly different between CGRP mAb and placebo groups. Similar efficacy and safety results were obtained for erenumab, fremanezumab, and galcanezumab in subgroup analysis.Conclusions The current body of evidence reveals that CGRP mAb is an effective and safe preventive treatment for episodic migraine.
Outbreak Investigation of a Multipathogen Foodborne Disease in a Training Institute in Rabat, Morocco: Case-Control Study
Authors: Moumni Abdou Houda , Dahbi Ilham , Akrim Mohammed , Meski Fatima Zahra , Khader Yousef , Lakranbi Mohammed , Ezzine Hind , Khattabi Asmae 
Published: September 2019

Background
On June 18, 2017, the public health service was alerted about 43 students in the training institute in Rabat who were admitted to the emergency room for acute gastroenteritis following the uptake of a meal a day before.

Objective
This study aimed to investigate the foodborne disease outbreak by confirming the outbreak, identifying the source of contamination, and recommending control measures.

Methods
We conducted a case-control study. Cases and controls were selected in a ratio of 1:1. We defined a case as any member of the training institute who attended the Ramadan buffet in the institute’s restaurant and who had presented, in the weekend of June 16 to 20, 2017, symptoms of diarrhea or vomiting with at least one of the following signs: abdominal pain, fever, headache, nausea, and dizziness. A control was defined as anyone who attended the Ramadan buffet in the institute’s restaurant but had not presented any symptoms from June 16 to 20, 2017. We conducted a bivariate and multivariable analysis. Stools of ill students were collected, and a food specimen was collected for bacterial testing.

Results
A total of 50 cases and 50 controls were selected. Among the cases, males were predominant (43/50, 86%); the median age was 21 years. A total of 47 cases sought medical care. There were no hospitalizations and no deaths. The episode was short with an estimated average incubation period of 9 hours. The epidemic curve oriented toward a common source of contamination. Among food items, briwates were strongly associated with the illness with an odd ratio of 14.23 (95% CI 5.04-40.04; P<.001). Laboratory testing of briwates showed presence of Escherichia coli O157 and Staphylococcus aureus.

Conclusions
This foodborne disease outbreak was likely caused by briwates that was contaminated with S aureus and E coli. We recommended strengthening hygiene measures. Food handling techniques should be taught as part of continuous professional development for food handlers.
Media Exposure, Utilization, Satisfaction, and Need for Service Business Information of Consumers in the Digital Economy Era
Authors: Tansiri Ekachat , Devahastin Sirivimol 
Published: September 2019

Abstract
The objectives of this research were: 1) to study the media exposure, utilization, satisfaction, and need for service business information of consumers in the digital economy era, 2) to examine the relationships between the media exposure, utilization, and satisfaction with service business information of consumers in the digital economy era, and 3) to present the problems, obstacles, and suggestions regarding digital media communication of consumers in the digital economy era. A quantitative survey research method was applied. The sample consisted of 400 consumers in Bangkok, ages 37-50 years, who were exposed to digital media on tourism service businesses, such as websites, Facebook, YouTube, Instagram, blogs, and Line. The research tool was a questionnaire, and the statistics used in data analysis were percentage, mean, and standard deviation. Hypothesis testing was done by using the Pearson product-moment correlation coefficient. The results showed that most respondents were female, ages 37-40 years, worked in private companies, and had an average monthly income of 10,001-20,000 baht. The majority of respondents were exposed to YouTube videos and Facebook pages on restaurant service. Service business information was used to satisfy their personal interests. Regarding satisfaction with business information, YouTube was found to be the most interesting form of digital media, whereas the other forms of digital media needed the right content. The observed problem was outdated and unreliable information. The hypothesis testing showed that media exposure behavior was significantly correlated (at 0.05 level) with the media utilization and satisfaction with service business information of customers in the digital economy era. Based on the results, it is suggested that digital media be used in new media convergence and modern marketing for better control of the accuracy and reliability of data in order to ensure that the creation and development of digital media in the service sector is consistent with the digital economic policy of the national government.
Is Human Capital in Higher Education Ready for Thailand 4.0: A Case Study of SSRUIC Students, Nakorn Pathom Education Center
Authors: Kankaew Kannapat 
Published: September 2019

Abstract
Presently, the Thai government has implemented its so-called Thailand 4.0 policy to move away from the middle-income trap to a value-based economy. Howbeit, human capital development is a crucial part for driving the policy’s success. Hence, this study aims to assess the perception of Thailand 4.0, the factors affecting learning, and the effectiveness of teaching. A mixed method research approach was applied; this comprised researcher administered structured observation in the classroom and in-depth interviews. The AMOS was manipulated for structural equation modeling to test the relationship between exogenous and endogenous variables. The result revealed that 63 per cent of the respondents understand the policy at a fair level. Surprisingly, only 2 per cent were shown to have the highest degree of understanding the policy. Whilst, the top three factors affecting learning are enhancement from family, motives to learn, and passion to be successful in future careers. Whereas, the most preferable methods of learning are lecture, simulation and role-play. In summary, there are myriad methods for educating as well as multiple contexts affecting learning. In particular, the motives, values and culture of learners. As a result, teachers should motivate student more and prepare the teaching approaches that fit the specific learners of within each classroom.
Beyond the Politics of Inclusion: The Policy Environment and the Fate of Children with Disability in the Ghanaian Educational System
Authors: Mantey Efua Esaaba 
Published: September 2019

Abstract
The 1992 constitution of Ghana and other national legislative instruments guarantee and promote free compulsory universal basic education for all Ghanaian children irrespective of their background. This has been the practice for many years. Even though these policies have chalked some successes, especially regarding school attendance and gender parity, there still remains some level of uncertainty as to whether all Ghanaian children, especially those with disabilities, benefit from these policies. Using secondary information available, the paper provides an overview of the existing legislative instruments that seek to promote the adoption of inclusive education policy in Ghana. Evidence from the literature reveals that there are restrictions within the current policy provisions which make inclusive education not possible for children living with disabilities. The paper concludes and recommends that there should be some modifications or new developments of inclusive education to enable the system to accommodate the diverse educational needs of children with disabilities.
Evaluation of the chemical composition and bioactivity of essential oils from Cinnamomum camphora (L.) J.Presl. (Lauraceae), Piper nigrum L. (Piperaceae) and Stemona japonica (Miq.) (Stemonaceae) against Oryzaephilus surinamensis (Linnaeus, 1758) (Coleoptera: Silvanidae)
Authors: Wagan Tufail Ahmed , Li Xiang , Hua Hongxia , Cai Wanlun 
Published: September 2019

Abstract
Oryzaephilus surinamensis is a serious insect pest of many stored products. Repellency and fumigation tests were performed to manage it. Essential oils (EO) from three plants – Cinnamomum camphora, Piper nigrum and Stemona japonica – were tested on Oryzaephilus surinamensis in the laboratory. Repellency was tested on filter paper in Petri dishes at a concentration of 31.4 μg/cm2, and 20 adults (10 days old) were observed for repellency behaviour 12, 24, 48 and 96 hours after the bioassay without any food. Cinnamomum camphora EO was the strongest repellent (83.75 ± 1.83%), followed by the Piper nigrum and Stemona japonica EOs. The eggs were obtained by maintaining 20 individuals (males and females) for 24 h in a 100 mL glass jar containing 5 g of diet feed. To evaluate the effect of EO on the development of larvae and adults, a filter paper disc impregnated with 0.1 mL of EO was placed on the inner side of the lid of the jar containing the eggs and diet feed. After 40 days, the number of adults and larvae in the jar was counted. All three EOs exhibited bioactivity against the development of larvae and adults. A relatively low number of larvae and adults was recorded in Cinnamomum camphora, followed by Stemona japonica and Piper nigrum. Gas chromatography/mass spectrometry was used to identify the major compounds in the EOs. Further studies are recommended to evaluate their bioactivity against different insect pests in stored seeds.
Trogossitidae, Lophocateridae, Peltidae and Thymalidae (Coleoptera: Cleroidea) of Poland: distribution, biology and conservation
Authors: Miłkowski Marek , Tatur-Dytkowski Jan , Gutowski Jerzy M. , Ruta Rafał , Grzywocz Janusz , Konwerski Szymon , Królik Roman , Kubisz Daniel , Lasoń Andrzej , Melke Andrzej , Olbrycht Tomasz , Szołtys Henryk , Wanat Marek 
Published: September 2019

Abstract
Distributional data for 10 species of Peltidae, Lophocateridae, Trogossitidae and Thymalidae recorded from Poland are summarised, and numerous unpublished records are reported. Data on feeding and habitat preferences are analysed. Calitys scabra and Temnoscheila caerulea are probably extinct in Poland. Grynocharis oblonga, Nemozoma elongatum and Tenebroides mauritanicus are relatively common in Poland. Nemozoma caucasicum is currently spreading within Europe and several new records in Poland are reported. Peltis ferruginea, P. grossa, and Thymalus limbatus are restricted to natural forests in Poland, where they are sometimes abundant. We suggest adding Peltis ferruginea and Thymalus limbatus to the Polish Red List of Animals. The opinion that Grynocharis oblonga and Tenebroides mauritanicus are relicts of natural forests does not seem justified.
Idiopathic pulmonary fibrosis in patients with early-stage non-small-cell lung cancer after surgical resection
Authors: Nezka Hribernik , Igor Pozek , Izidor Kern 
Published: September 2019

Abstract

Background
The outcomes of patients with both lung cancer and idiopathic pulmonary fibrosis (IPF) are unfavorable. Therapeutic interventions for lung cancer such as surgery can cause acute exacerbation of IPF (aeIPF). This study aimed to assess the frequency of IPF in a group of patients with early-stage non-small-cell lung cancer (NSCLC) and to report clinical characteristics and outcomes of this cohort of patients.

Patients and methods
This observational cohort retrospective study analyzed 641 pathological records of patients after surgical resection of early-stage non-small-cell lung cancer (NSCLC) at University Clinic Golnik from May 2010 to April 2017. Pathological records of NSCLC with coexisting IPF were reviewed. CT scans and biopsy specimens for this group of patients were analyzed by a thoracic radiologist and pathologist, independently. We searched radiological and pathological features of usual interstitial pneumonia (UIP) pattern in this group of patients. We report the clinical characteristics and outcome of this cohort of patients.

Results
Out of 641 patients with early-stage NSCLC, only 13 (2.0%) had histologically and radiologically proven coexisting UIP/IPF. Squamous cell carcinoma was the most common type of lung cancer (7/13 patients). The majority of tumors were small size (all being pT1 or pT2), stage I–II (11/13 patients), located in the lower lung lobes (11/13 patients). Almost all patients were current or ex-smokers (11/13 patients). There were two pathologically confirmed fatal cases (15.4%) due to aeIPF in the first two months after radical treatment, one after adjuvant radiotherapy and the other after surgery. Out of 13 patients, one patient had a lung cancer relapse.

Conclusions
Frequency of UIP/IPF in surgically treated early stage NSCLC is rather low. Our observational study shows that radical treatment of lung cancer can cause aeIPF with dismal outcome in this group of patients. The standard of care in these mostly elderly patients still remains unresolved.
Relationship between sex hormones levels and 18F-FDG uptake by the ovaries in premenopausal woman
Authors: Kim Tae Hee , Kim Mi Ran , Jung Yongsik , An Young-Sil 
Published: September 2019

Abstract

Background
The study was conducted to evaluate the effect of sex hormones on F-18 fluorodeoxyglucose (18F-FDG) uptake by normal ovaries.

Patients and methods
A total of 197 premenopausal women were included in this study. Based on 18F-FDG positron emission tomography/computed tomography (PET/CT) images obtained from these subjects, the association of ovarian 18F-FDG uptake with levels of sex hormones, including estradiol, progesterone, testosterone, follicle-stimulating hormone, and luteinizing hormone was investigated. We also analysed the relationship between the menstrual cycle and ovarian 18F-FDG uptake.

Results
The highest ovarian 18F-FDG uptake occurred at 2 weeks after the onset of menstruation (median maximum standardized uptake value [SUVmax] = 3.40, median mean SUV [SUVmean] = 2.20), and the lowest ovarian 18F-FDG uptake was observed during the first week of the menstrual cycle (median SUVmax = 1.60, median SUVmean = 1.20). Ovarian 18F-FDG uptake was weakly positively correlated with progesterone levels (rho = 0.28, p < 0.001 for SUVmax, rho = 0.30, p < 0.001 for SUVmean), and this pattern was consistently observed in subjects in the follicular-phase group (rho = 0.29, p = 0.003 for both SUVmax and SUVmean) but not in subjects in the luteal-phase group.

Conclusions
Based on PET images, ovarian glucose metabolism in premenopausal women tended to increase slightly with increasing progesterone concentration.