bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE LEARNING MEDIA DEVELOPMENT MODULE OF TECHNICAL IMAGES BASED ON CYCLE 5E LEARNING APPROACH
Authors: Astuti Indriana Yuni , Widiastuti Indah , Basori Basori 
Published: July 2019

<p><em>This research analysist engineering drawing module that developed based on Learning Cycle 5E approach includes engagement, exploration, elaboration, evaluation and adapted to the Competency Standards and Basic Competencies of Curriculum 2013. Learning Cycle 5E was chosen as a development model because it is considered in line with the Curriculum 2013. The objective of this research are : (1) Developing a learning media Drawing Technique in the form of module based on learning cycle approach 5E as supporting technical drawings subjects in SMK. (2) Doing fesibility analysis developing a learning media drawings technique in the form of module based on learning cycle approach 5E as supporting technical drawings subjects in SMK based on material assesment, media, and teacher's subjects.</em></p><p><em>Developing a learning media module drawing technique based on learning cycle approach 5E refer to developing 4D thiagarajan model. Developing 4D model consists of 4 main steps: define, design, development, and disseminate. Because there are some reason, this developing research is limited to development steps. While for the disseminate is doing with the questionnaire of teacher responses.</em></p><p><em>The results of this research are: (1) A Learning Cycle 5E Engineering Drawing Module developed on the basic competence of the size tags and layout of image size, sign recognition and the location of the cut image, the introduction and application of the cut image type. (2) Feasibility study engineering drawings Module media-based Learning Cycle 5E Approach derived from the results of the expert assessment of the material and media experts. The result of the expert assessment of the material obtain an average percentage 87.5% it is included on the criterion of "very good". The results of the assessment of the experts the media earn the average percentage of 88.006% and included on the criterion of "very good", and now from the responses the teacher obtained the mean percentage of 91.67%, it is included in the criteria of "very good".</em></p><p> </p>
THE EFFECT OF ETHANOL ADDITION ON VEHICLE FUEL CONSUMPTION IN ECONOMIC TERMS - A REVIEW
Authors: Muhsin Muhsin 
Published: July 2019

<p>The technological development of the automotive sector is increasing, every year there is an increase in the production of motor vehicles in Indonesia. The increase in motorized vehicles will certainly have an impact on the use of fuel oil which is also increasing. Though fuel oil is a non-renewable fossil fuel, so that continuous use can lead to scarcity of fossil fuels someday. In addition to causing scarcity of fossil fuels, the increasing number of vehicles will also cause the surrounding environment to be increasingly polluted by the exhaust emissions from the combustion process of the motorized vehicles. Various alternatives are used as a mixture of fuels to reduce fuel consumption and vehicle exhaust emissions, such as ethanol, hydrogen, butanol, biodiesel, methanol etc. The purpose of this literacy study was to determine the effect of using ethanol on fuel consumption and its economic value. Based on the results of a study of literacy is known that the addition of ethanol does reduce the level of fuel consumption, However, if viewed from an economic perspective, the addition of ethanol has actually caused the purchase price of fuel to increase, this will certainly hinder the growth of the desire to use ethanol as an alternative source of fuel substitute by the people of Indonesia.</p>
TRADISI KHATAMAN Al-QUR’AN VIA WHATSAPP Studi Kasus Anak-Cucu Mbah Ibrahim al-Ghazali Ponorogo Jawa Timur
Authors: Fauzi Moh Hasan 
Published: July 2019

Abstract: This article is intended to describe the tradition of reciting Al-Qur'an through whatsapp. The writer discussed how the Muslim responds to social media especially whatsapp, then, how the acceptance of the Qur'an is highlighted. Whatsaap changed the concept of reciting al-Qur'an from offline to online. The writer assumes that the existence of these activities can encourage anyone to recite Al Qur’an and strengthen togetherness. It implies that Qur'an has a function as an informative as well as a performative aspect. The significance of social media through Whatsaap in reciting Al-Qur'an tradition, model, results from that tradition is to get a reward from Allah. This study employed phenomenological approach. The findings showed that reciting Al-Qur'an through whatsapp motivated people to read the Qur'an and foster togetherness. Further, the presence of contestations from several families is arisen in this new tradition.الملخص: يحاول هذا المقال وصف عادة ختم القرآن بوسائل الاتصال الاجتماعي (whatsapp). أولاً، سيشرح الباحث كيفية استجابة العالم الإسلامي لوسائل الاتصال الاجتماعي (whatsapp). التالي سوف يشرح كيفية استقبال القرآن. غيّر Whatsaap ختم القرآن من دون اتصال بالإنترنت إلى عبر الإنترنت. يفترض الباحث أن هذه الأنشطة تشجع شخصًا على قراءة القرآن وتقوية صلة الرحم بوجود الاجتماع كل ثلاثة أشهر. هذا يعني أن القرآن ليس له جانب إعلامي فحسب، بل له جانب أداء. ما هي أهمية وسائل الاتصال الاجتماعي (whatsaap) من عادة ختم القرآن؟ كيف نموذج عادة ختم القرآن عبر Whatsaap؟ وما انتاج ختم القرآن بجانب الحصول على الثواب من الله؟ في هذه الدراسة، استخدم الباحث المنهج الظواهري. وجد الباحث أن شخصًا يديم قراءة القرآن ويتولد منه صلة الرحم. هناك مسابقات من عدة عائلات لأن ليس كل العائلات تشارك في هذه العادة الجديدة.Abstrak: Artikel ini ingin berusaha mendeskripsikan bagaimana tradisi khataman al-Qur’an dengan media sosial yaitu whatsapp. Untuk itu, pertama, penulis akan menjelaskan bagaimana dunia muslim merespon media sosial (whatsapp). Selanjutnya akan menjelaskan bagaimana resepsi (penerimaan) terhadap al-Qur’an. Whatsaap merubah khataman al-Qur’an dari offline ke online. Penulis berasumsi dengan adanya kegiatan tersebut bisa mendorong seseorang untuk selalu membaca al-Qur’an dan bisa mempererat sillaturahmi dengan fakta lapangan adanya pertemuan setiap 3 bulan sekali. Di sini berarti al-Qur’an itu tidak hanya punya sisi informatif tapi juga sisi performatif. Apa signifikansi media sosial (whatsaap) dari tradisi khataman al-Qur’an. Bagaimana model tradisi khataman al-Qur’an via whatsapp. Apa yang dihasilkan dari tradisi tersebut selain mendapat pahala dari Allah. Dalam penelitian ini, penulis menggunakan pendekatan fenomenologi. Penulis menemukan seseorang terdorong untuk selalu membaca al-Qur’an dan terciptanya silaturahmi. Ada kontestasi dari beberapa keluarga karena tak semua keluarga berpartisipasi dalam tradisi yang baru ini.
Nursing students’ knowledge, attitude, self-efficacy in blended e-learning of cardiopulmonary resuscitation: a randomized controlled trial
Authors: Moon Hyunjung , Hyun Hye Sun 
Published: July 2019

Abstract
Background: Although various forms of online education are on the rise worldwide, effects of such innovative approach are yet to be validated. This study analyzes whether blended e-learning cardiopulmonary resuscitation (CPR) education that integrates e-learning and face-to-face education is effective in improving nursing students’ knowledge, attitude, and self-efficacy.
Methods: The participants of this study were 120 nursing students randomly assigned to the intervention group (n = 60) or the control (n = 60). Differences before and after the education of each group were analyzed with a paired t-test, and the differences between the two groups were analyzed with ANCOVA with knowledge as the covariate.
Results: The findings indicated that the intervention group had significantly higher knowledge, F(1,117) =595.78, p <.001, and emotional attitude, F(1,117) = 9.61, p = .002, about CPR than the control group.
Conclusions: Blended e-learning CPR programs could be used as effective supplemental CPR education for nursing students.
Caring for a Chronically Ill Child While Employed: A cross sectional study on the impact on the quality of life of Jordanian mothers
Authors: Gharaibeh Huda , Gharaibeh Muntaha 
Published: July 2019

Abstract
1. Abstract

Background: The quality of life of working women who cares for a child with chronic illness is of interest to families and health care professionals, as balancing work-life and routines of daily life gets complex when a child is chronically ill. The purpose of the study was to examine the QOL of working and non-working mothers caring for children with a chronic illness in Jordan.
Results: Data from 164 mothers who cared for children with chronic illness were collected between November 2015 and April 2016 for this descriptive comparative cross sectional study
using The World Health Organization Quality of Life – BREF (WHOQOL-BREF) tool and examined the physical, psychological, social relationships, and environment domains of their quality of life. The quality of life of working mothers was significantly lower than those of non-working mothers on all domains of WHOQOL-BREF. Mother’s working status, monthly income, evaluation of their own health explained 41% of the variance; adjusted R2 was 0.41, F= (22.17, 157), P <0.0001
Conclusions: Social, family and employer support may help mothers overcome the challenges of caring for a child with a chronic illness and maintain good QOL.
Key words: Quality of life, mothers, chronic illness, children
Effects of Depression, Dementia and Delirium on Activities of Daily Living in Elderly Patients after Discharge
Authors: Weng Ching Fu , Lin Kun-Pei , Lu Feng-Ping , Chen Jen-Hau , Wen Chiung-Jung , Peng Jui-Hua , Tseng Ailun Heather , Chan Ding-Cheng 
Published: July 2019

Abstract
Background

The three geriatric conditions, depression, dementia and delirium (3D’s), are common among hospitalized older patients and often lead to impairments of activities of daily living. The aim of this study is to explore the impact of depression, dementia and delirium on activities of daily living (ADLs) during and after hospitalization.

Methods

A prospective cohort study was conducted between 2012 and 2013 in a tertiary medical center in Taiwan. Patients aged 65 years and older admitted to the geriatric ward were invited to this study. Geriatric Depression Scale Short Form, Mini-Mental State and Confusion Assessment Method were used to identify patients with depression, dementia and delirium on admission, respectively. Barthel Index (BI) was used to evaluate patients’ functional status on admission, at discharge, 30-day, 90-day and 180-day after discharge. Generalized Estimating Equation was used to calculate the associations between 3 D’s and BI.

Results

One-hundred-and-forty-nine patients were included in this study. Twenty-seven patients (18.1%) had depression, 37 (24.8%) had dementia, and 85 (57.0%) had delirium. There were significant lower BI scores in patients with dementia and delirium compared with those without up to 180 days after discharge, but no difference was seen in the depression group. In general, patients had delirium or dementia had worsening functional status, even though significant magnitude of improvements on BI scores after discharge.

Conclusions

Depression does not affect patients’ ADLs. On the other hand, dementia and delirium can persistently limit patients’ physical function. Future care should focus more on dementia and delirium to restore function.
Improving surgical outcomes in advanced ovarian cancer: a UK centre quality improvement strategy
Authors: May James , Congiu Mario , Fegan Scott , Ghaoui Nidal , Anderson David , Collie Mhairi , Rye Tzyvia , Gourley Charlie , Martin Cameron W 
Published: July 2019

Abstract
Purpose

National outcomes for epithelial ovarian cancer in the UK are inferior to those in other European countries. This study aimed to assess the impact of a multidisciplinary approach to cytoreductive surgery on residual disease status and progression free survival in a single UK region.

Methods

Consecutive patients undergoing surgery for stage III/IV epithelial ovarian cancer between November 2011 and November 2015 in South East Scotland were analysed. Regular multidisciplinary surgery was established on 1st November 2013. Outcomes for patients diagnosed in the two years prior to (group 1) and following this change (group 2) in practice were examined.

Results

224 consecutive patients underwent surgery. There was no difference between groups in terms of age, FIGO stage or histological subtype. Patients in group 2 were more likely to undergo primary surgery (p=0.01) and bowel resection (p=0.002). Rates of optimal cytoreduction were not significantly different between group 1(69.6%) and group 2 (66.1%) (p=0.67). The upper abdomen was the most common site of residual disease. No difference in PFS (median PFS; 15.5 vs. 14.0 months, p=0.13), morbidity (p=0.82) or mortality (p=1.00) was identified. PFS was improved in those patients undergoing primary surgery compared to neoadjuvant chemotherapy (p=0.04).

Conclusion

Robust quality improvement strategies are required to overcome historic barriers to cytoreductive surgery in the UK. Comprehensive attempts at debulking in the upper abdomen are required if rates of complete cytoreduction are to be improved. We have extended the multidisciplinary model in our institution to include upper abdominal surgery and anticipate an improvement in cytoreduction.
Policies and programs for the prevention of gastrointestinal cancers in Iran: a document analysis
Authors: Kabiri Neda , Khodayari-zarnaq Rahim , Khoshbaten Manouchehr , Jannati Ali 
Published: July 2019

Abstract
Background

Considering the importance of gastrointestinal cancers and their high prevalence in Iran, the analysis of national and local programs and policies are of high importance. The current document review was conducted to assess policies and programs related to the prevention of colon, stomach, liver, esophageal and pancreas cancers in Iran.

Methods

This paper used 'policy triangle' as a framework to analyze documents related to gastrointestinal cancer prevention in Iran. We searched PubMed and SCOPUS, as well as web pages of Ministry of Health and Medical Education (MOHME), all Medical Sciences Universities, and some related research centers. Documents were analyzed using MAXQDA 10 software.

Results

Three documents, one guideline, 16 national meeting reports, and 11 articles were found containing or describing interventions directed at the prevention of gastrointestinal cancers in Iran. Also, a large amount of news was obtained from the searched web pages. Findings of this paper are organized based on the four aspects of health policy triangle including content, context, process, and actors. Health affairs of MOHME developed a plan, called 'Iran Package of Essential Non-communicable Disease’ (IraPEN), for preventing three common cancers namely colorectal, breast, and cervix in 2015. The contextual factors affecting prevalence and incidence of gastrointestinal cancers in this country included economic, social, and cultural. Regarding high prevalence and incidence of gastrointestinal cancers in Iran, prevention programs have been developed in this country since 2012 and have been implemented in some areas. However, these programs don’t have any evaluation phase within them. The most effective actor in preventing these cancers in Iran is MOHME.

Conclusions

Considering the interventions conducted to prevent gastrointestinal cancers in the country, the prevalence and incidence of these cancers have not been diminished. This issue needs care of policy makers in health and other sectors to design and implement policies and strategies in order to prevent these cancers at the primary level. Also, non-governmental organizations might be attracted to provide financial support.
Prescribing of different antibiotics, rates of sepsis-related mortality and bacteremia in the US and England, and the utility of antibiotic replacement vs. reduction in prescribing: a cross-sectional study
Authors: Goldstein Edward 
Published: July 2019

Abstract
Background

Antibiotic use contributes to the rates of bacteremia, sepsis and associated mortality, particularly through lack of clearance of resistant infections following antibiotic treatment. At the same time, there is limited information on the effects of prescribing of some antibiotics vs. others on the rates of outcomes related to severe bacterial infections.

Methods

We looked at associations between the proportions (state-specific in the US; Clinical Commissioning Group (CCG)-specific in England) of different antibiotic types/classes among all prescribed antibiotics in the outpatient setting (oral antibiotics in the US), and rates of outcomes (mortality with sepsis, ICD-10 codes A40-41 present as either underlying or contributing causes of death on a death certificate in different age groups of US adults; E. coli as well as MSSA bacteremia in England) per unit of antibiotic prescribing (defined as the rate of outcome divided by the rate of outpatient prescribing of all antibiotics).

Results

In the US, prescribing of penicillins was associated with rates of mortality with sepsis for persons aged 75-84y and 85+y between 2014-2015. In England, prescribing of penicillins other than amoxicillin/co-amoxiclav was associated with rates of both MSSA and E. coli bacteremia for the period between financial years 2014/15 through 2017/18. Additionally, multivariable analysis for the US data has also shown an association between the percent of individuals aged 50-64y lacking health insurance, as well as the percent of individuals aged 65-84y who are African-American and rates of mortality with sepsis in the corresponding age groups.

Conclusions

Our results suggest that prescribing of penicillins is associated with rates of E. coli and MSSA bacteremia in England, and rates of mortality with sepsis in older US adults. Those results, as well as the related epidemiological data suggest that replacement of certain antibiotics, particularly penicillins in the treatment of certain syndromes should be considered for reducing the rates of outcomes related to severe bacterial infections.
Vancomycin loading dose is associated with increased early clinical responses without attainment of initial target trough concentration at a steady state in patients with normal renal function
Authors: Ueda Takashi , Takesue Yoshio , Nakajima Kazuhiko , Ichiki Kaoru , Ishikawa Kaori , Takai Yoshiko , Yamada Kumiko , Wada Yasunao , Tsuchida Toshie , Otani Naruhito , Takahashi Yoshiko , Ishihara Mika , Shibata Sumiyo , Ikeuchi Hiroki , Uchino Motoi , Kimura Takeshi 
Published: July 2019

Abstract
Background

Vancomycin therapeutic guidelines suggest a loading dose of 25–30 mg/kg for seriously ill patients. However, high-quality data to guide the use of loading dose are lacking. Evaluate whether a loading dose 1) achieves a target trough concentration (Cmin) at steady state and 2) improves early clinical responses.

Methods

Patients with an estimated glomerular filtration rate ≥90 mL/min/1.73 m2 were included. A loading dose of 25 mg/kg vancomycin followed by 15 mg/kg twice daily was compared with traditional dosing. A Cmin sample was obtained before the fifth dose. An early clinical response 48–72 h after the start of therapy and clinical success at end of therapy (EOT) was evaluated in patients with methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant coagulase-negative Staphylococci, or Enterococcus faecium.

Results

There was no significant difference in Cmin between the regimen with and without a loading dose (median: 10.4 µg/mL and 10.2 µg/mL, P=0.538). Proportions of patients achieving 10–20 µg/mL and 15–20 µg/mL were 56.9% and 5.6%, respectively, in patients with a loading dose. Although there was no significant difference in success rate at EOT between groups, loading dose was associated with increased early clinical responses for all infections [adjusted odds ratio (OR): 4.829, 95% confidence interval (CI): 1.441–16.188] and MRSA infections (OR: 10.851, 95% CI: 1.701–69.233). Increased adverse events were not observed with the loading dose. Study limitations included no Cmin measurements within 24 hours, and the inclusion of less critically ill patients.

Conclusions

Although the loading dose did not achieve optimal Cmin at steady state, a higher early clinical response was obtained compared with traditional dosing.
The impact of IGF1R SNPs on susceptibility to age-related cataract
Authors: Cui Yilei , Yu Xiaoning , Zhang Xin , Tang Yelei , Tang Xiajing , Yang Hao , Ping Xiyuan , Wu Jing , Yin Qinchuan , Zhou Jiayue , Xu Xiayan , Shentu Xingchao 
Published: July 2019

Abstract
Background: The insulin-like growth factor 1 receptor (IGF1R) gene is essential for lens development, but the impact of IGF1R on age-related cataract(ARC) has not been investigated. This study explored the association between IGF1R single nucleotide polymorphism (SNP) and ARC susceptibility ,and uncover the underlying mechanism in human lens epithelial (HLE) cells.
Methods:A total of 1190 unrelated participants ,comprising 690 ARC patients and 550 healthy individuals in Han Chinese population were recruited and genotyped for target SNP. The X2-test was used to detect genotypic distribution between the patient and control groups and the logistic regression was performed to adjust the age and gender. Meanwhile, in the IGF1R knockdown HLE cells, cell proliferation was detected via CCK-8 analysis. Cell cycle and apoptosis were evaluated by flow cytometry,while the expression of cycle- and apoptosis-related molecules were determined via Q-PCR and Western blot. The Caspase-3 activity was measured using its assay kit.
Results: The rs1546713 in IGF1R gene was identified（P =0.046，OR：1.606，CI：1.245,2.071）,which shown a significant relevance with ARC risk under the dominant model. The results demonstrated that IGF1R knockdown inhibited cell proliferation by inducing cell cycle arrest at S phase and promoting apoptosis. Mechanistically, the cell cycle blocked at S phase was linked with the alterations of cyclinA , cyclinB, cyclinE and P21,while the pro-apoptosis function was related to stimulate the activation of Caspase-3 activities and the alteration of Caspase-3,Bcl-2 and Bax expression levels.
Conclusions: This study first reported that IGF1R polymorphisms may affect susceptibility to ARCs in Han Chinese population and provided new clues to understanding the pathogenic mechanism of ARCs. Notably, IGF1R is likely a potential target for ARC prevention and treatment.