bluuebunny/crossref_metadata_2025_split huggingface dataset:
АКТУАЛЬНОСТЬ ВОЗРОЖДЕНИЯ КОМПЛЕКСА «ГОТОВ К ТРУДУ И ОБОРОНЕ» НА ПРИМЕРЕ СТУДЕНТОВ ТЕХНИЧЕСКОГО ВУЗА
Authors: Gladkikh Artem Stanislavovich , Davydov Sergei Alekseevich , Nerubalskaya Elena Viktorovna , Nerubalskaya Elena Viktorovna 
Published: February 2018

Согласно плану мероприятий, по этапному внедрению Всероссийского физкультурно-спортивного комплекса «Готов к труду и обороне» (ВСФК ГТО), утвержденным распоряжением Правительства РФ от тридцатого июня 2014 года, комплекс ГТО с 2016 года должен быть внедрен среди обучающихся всех образовательных организаций страны. Анализ сложившейся ситуации показывает, что проблема заключается в недостатке научно обоснованных сведений о содержании комплекса для сдачи студентам нормативов «Готов к труду и обороне» (ГТО).Целью исследования является провидения эксперимента для проверки знаний студентов содержания комплекса ГТО в целях подготовки к сдаче норм ГТО на основе актуализации педагогического и оздоровительного потенциала высшего учебного заведения (ВУЗа). В данной статье рассматриваются результаты обработки анкеты.Основной целью исследования являлось изучение мнения о степени подготовки студентов Волгоградского государственного технического университета (ВолгГТУ) к сдаче комплекса «Готов к труду и обороне».
The Possibility of Using the Sodium-Fluoride, 18F at Non-Neoplastic Lesions of Bone Tissue (Experimental Study)
Authors: Костеников Н. , Kostenikov N. , Миролюбова О. , Mirolyubova O. , Дубровская В. , Dubrovskaya V. , Клестова О. , Klestova O. , Кованько Е. , Kovan'ko E. , Изотова Н. , Izotova N. , Илющенко Ю. , Ilyuschenko Yu. , Станжевский А. , Stanzhevskiy A. 
Published: February 2018

Purpose: To study the possibility of using radiopharmaceutical (RPH) Sodium fluoride, 18F (Na18F) in order to identify the characteristics and dynamics of the development process for a number of non-neoplastic lesions in bone tissue such as fractures and osteoporosis in experimental animals by the method of positron emission tomography (PET).
Material and methods: Two experimental models of pathology of bone tissue in rats were used: fracture and osteoporosis.
The model of osteoporosis was created by intraperitoneal introduction of hydrocortisone during 3 weeks. The study was conducted in 22 days from the onset of the agent introduction. In areas of the chest and sacral sections of the spinal cord in experimental and intact animals we detected the value of uptake of Na18F, as well as indices of tissue density with data of X-ray CT.
In the model of fracture of bones injury struck in the pre-anesthetized rats in the region of the shin. Animals were examined starting from the 3rd day up to the 30th day after the fracture by PET and PET/CT. We detected the value of uptake, the dynamics of Na18F accumulation, as well as indices of densitometry and signs of callus formation with CT examination.
Results: In rats with osteoporosis compared with intact animals observed a 2,5-fold decrease of the bone tissue density in X-ray, whereas the level of metabolic activity in the bones of the PET scan with Na18F was 5.6 times lower than in healthy rats. Therefore, differences in the level of capture of the radiopharmaceutical in PET were significantly more important compared to the ratio of the values of the X-ray of the bone tissue density, determined by CT.
In experiments with shin fracture was noted hyperfixation and increasing rate of Na18F accumulation on PET-scans since the 9th and 30th day from the start of the experiment. It reflects a process of enhancing the metabolism in the injured area. At the same time, a significant increase of densitometric density and visualisation of callus formation in the fracture by CT were detected 3 weeks later, – only by the 30th day after trauma.
Conclusion: The use of Na18F in positron-emission tomography enables to diagnose more early and accurate the nature (osteoporosis) and intensity of processes of the restoration (fracture) in the injured bone tissue as compared to results of computed tomography.
Structure Modification of Ethyl p-methoxycinnamate Isolated from Kaempferia galanga Linn. and Citotoxicity Assay of The Products on WiDr Cells
Authors: Ekowati Juni , Rudyanto Marcellino , Sasaki Shigeru , Budiati Tutuk , - Sukardiman , Hermawan Adam , Meiyanto Edy 
Published: February 2018

Ethyl p-methoxycinnamate, major ingredient of Kaempferia galanga rhizome, have been reported not only has analgesic – anti inflammatory activities like NSAIDs which inhibited cyclooxygenase, but also inhibit tumor cell proliferation in specimen of mouse epidermis. Therefore, it will be interesting to carry out synthetic studies on the derivates of ethyl p-methoxycinnamate and searching their citotoxic activity on WiDr cell. We wish to report of structure modification on carboxyl moiety of ethyl p-methoxycinnamate and evaluation on their citotoxic activity on WiDr cell. Isolation of ethyl p-methoxycinnamate from Kaempferia galanga rhizome was carried out by percolation with ethanol 96% as solvent. Hydrolysis of ethyl p-methoxycinnamate in basic condition was performed to obtain p-methoxycinnamic acid. Preparation of some thiourea derivates of ethyl p-methoxycinnamate was carried out by microwave irradiation. Citotoxicity assay was carried out by MTT method for 48 h.Modification of carboxyl group of ethyl p-methoxycinnamate to its thiourea form could be carried out by microwave irradiation gave; (E)-3-(4-methoxyphenyl)-N-(phenylcarba- mothioyl)acrylamide (50%); (E)-3-(4-methoxyphenyl)-N-(4-methoxyphenylcarbamothi- oyl)acrylamide (26%) and (E)-3-(4-methoxyphenyl)-N-(4-methylphenylcarbamothioyl) acrylamide (54%), yield calculated for 2 step from the acid chloride. All compounds showed no citotoxic effect on WiDr cell at 48 h incubation.Keywords : ethyl p-methoxycinnamate, microwave irradiation, Kaempferia galanga, citotoxicity, WiDr cell
Antioxidant Activity of Garcinia cf bancana Miq
Authors: Hartati Sri , Triyem Triyem , Cahyana Herry 
Published: February 2018

Guttiferron F and essential oil were isolated from extract n-hexane of Garcinia cf bancana Miq. Antioxidant activity was done by DPPH method to n-hexane, methanol, ethyl acetate, n-butanol extracts and Guttiferron F, showed activity with IC50 24.5, 22.4, 29.2, 37.6 and 25.8 µg/mL respectively. The structure elucidation of Guttiferon F based on spectroscopy data of IR, NMR of 1H and 13C.Keywords: Antioxidant, Garcinia cf bancana Miq., Essential oil and Guttiferon-F.
In Vitro Anti-Cancer Alkaloid and Flavonoid Extracted from the Erythrina variegata (Leguminoseae) Plant
Authors: Herlina Tati , Supratman Unang , Subarnas Anas , Sutardjo Supriyatna , Amien Suseno , Hayashi Hideo 
Published: February 2018

Erythrina plants, locally known as “dadap ayam”, are higher plant species and have been used as a folk medicine for treatment of cancer. To prove the effectiveness of the leaves and stem bark of E. variegata as an anti-cancer agent, the assay in this research was focused on in vitro test towards breast cancer cell T47D. In the course of our continuing search for novel anti-cancer agent from Erythrina plants, the methanol extract of the leaves and stem bark of E. variegata showed significant anti-cancer activity against breast cancer cell T47D in vitro using the Sulphorhodamine B (SRB) assay. By using the anti-cancer activity to follow the separations, the methanol extract was separated by combination of column chromatography. The chemical structure of an anti-cancer compounds were determined on the basis of spectroscopic evidence and comparison with the previously reported and identified as an erythrina alkaloid (1) and isoflavonoid (2). Compounds (1-2) showed anti-cancer activity against breast cancer cell T47D used with IC50 of 1.0 and 3.3 µg/mL, respectively. This results strongly suggested that E. variegata is promising sources for anti-cancer agents. Keywords: Anti-cancer, Erythrina variegata, Leguminoseae
Aristotle on the Truth About Practical Ends
Authors: Olfert Christiana Megan Meyvis 
Published: February 2018

AbstractAristotle holds that rational agents can think true thoughts about their practical ends. Specifically, we can think true thoughts about whether our ends are good and able to be brought about in action. But what makes these thoughts true? What sort of thing is a practical end, such that it both is good, and also may be brought about in the future? These questions are difficult to answer. They are metaphysical questions about Aristotle’s practical philosophy: they ask what practical ends are, such that they can make true certain parts of our practical thinking. What is more, key claims in Aristotle’s account of rational agency seem to make it impossible for thoughts about our practical ends to ever, in fact, be true. Given the ways in which we think about our ends, there seems to be nothing in the world to which these thoughts truthfully correspond. In this paper, I identify and solve two puzzles for Aristotle’s claim that we can think true thoughts about our practical ends. These puzzles have not been discussed in recent literature, but they have potentially wide-reaching consequences for Aristotle’s account of rational agency and motivation. My solution offers a novel account of the metaphysics of practical ends, which explains how these ends can be truth-makers for our thoughts about them. I argue that we should understand practical ends on the model of first actualities, which are also second potentialities. The idea that some actualities are also potentialities is a complicated one, but as I hope to show, it yields a straightforward and illuminating conception of practical ends. It also adds a crucial metaphysical component to Aristotle’s account of rational agency, one which shows how this account is internally consistent.
Higher D-lactate levels are associated with higher prevalence of small dense low-density lipoprotein in obese adolescents
Authors: Rodríguez-Mortera Reyna , Luevano-Contreras Claudia , Solorio-Meza Sergio , Caccavello Russell , Bains Yasmin , Garay-Sevilla Ma Eugenia , Gugliucci Alejandro 
Published: February 2018

Abstract

Background:
Childhood obesity is associated with insulin resistance (IR), increased levels of small dense low-density lipoprotein (sd-LDL) as well as with augmented hepatic de novo lipogenesis, which implies increased triose phosphate fluxes that may lead to increased methylglyoxal (MG) and its catabolic end product D-lactate. We hypothesized that obese adolescents have increased D-lactate serum levels associated with high incidence of sd-LDL.

Methods:
This is a cross-sectional study where the anthropometric characteristics, atherogenic dyslipidemia complex, sd-LDL (Lipoprint, Quantimetrix) and D-lactate (kinetic enzymatic analysis) were explored in 30 lean vs. 30 obese adolescents (16 females and 14 males per group) without metabolic syndrome (MetS). Endothelial function by flow-mediated dilation (FMD, by ultrasound) and arterial lesion by carotid intima media thickness (CIMT, by ultrasound) were also measured.

Results:
The mean age of participants was 16.8 ± 1.4 years. Obese adolescents had a body mass index of 32.7 ± 3.8 vs. 21.8 ± 2.1 in lean participants. The obesity group showed higher D-lactate levels: 6.2 ± 3.0 vs. 4.5 ± 2.5 μmol/L, higher levels of insulin: 15 (9.6–23.5) vs. 7.9 (6.5–10.5) μIU/mL; triglyceride (TG): 1.46 (1.1–1.8) vs. 0.84 (0.6–1.2) mmol/L; non-high-density lipoprotein-cholesterol (NON-HDL-C): 2.8 ± 0.9 vs. 2.3 ± 0.7 mmol/L; total cholesterol (TC)/HDL-C) index: 2.9 ± 0.7 vs. 2.4 ± 0.5; TG/HDL-C index: 2.2 (1.5–2.8) vs. 1.1 (0.8–1.8); %LDL-3: 4.2 ± 4.07 vs. 1.9 ± 2.7; smaller LDL size: 270.6 ± 3 vs. 272.2 ± 1.1 Å. D-lactate correlated positively with LDL-2: r = 0.44 and LDL-3 (sd-LDL): r = 0.49 and negatively with large LDL-1: r = −0.48 and LDL size: r = −0.46; (p<0.05, p<0.01, p<0.001 and p<0.0001, respectively). Obese adolescents showed higher CIMT: 0.51 ± 0.08 vs. 0.46 ± 0.08 mm and lower FMD: 20.3% ± 6.7% vs. 26.0% ± 9.3%.

Conclusions:
Obese adolescents display subclinical signs of IR and endothelial dysfunction. Higher serum sd-LDL levels correlated positively with D-lactate levels. These findings suggest an association between atherogenic dyslipoproteinemia and whole body MG fluxes already detectable in apparently healthy obese adolescents.
Properties related to linear and branched network structure of hydroxyl terminated polybutadiene
Authors: Ou Yapeng , Sun Yalun , Jiao Qingjie 
Published: February 2018

AbstractThe correlation between properties and the network structure of hydroxyl terminated polybutadiene (HTPB) based polyurethanes (PUs) was studied through linear and branched structure polymer matrixes formed by toluene diisocyanate (TDI) and an aliphatic polyisocyanate curing agent (N100). The curing reactions were monitored using differential scanning calorimetry (DSC) and viscosity build-up. The swelling capacity of PUs decreased with the increase of crosslink density with a stable solubility parameter according to the equilibrium swelling test. Tensile properties of PUs cured by TDI and N100 in different stoichiometric ratios of NCO/OH groups were tested. Both breaking elongation and tensile strength were remarkably improved by N100. The thermal decomposition processes of HTPB/TDI and HTPB/N100 indicated that a branched structure has higher depolymerization temperature, and hence, improved thermal stability. In addition, PU with a branched network prevented the migration of the plasticizer during isothermal accelerated aging due to the higher crosslink density.
The AGO proteins: an overview
Authors: Niaz Saife 
Published: February 2018

Abstract
Small RNAs govern almost every biological process in eukaryotes associating with the Argonaute (AGO) proteins to form the RNA-induced silencing complex (mRISC). AGO proteins constitute the core of RISCs with different members having variety of protein-binding partners and biochemical properties. This review focuses on the AGO subfamily of the AGOs that are ubiquitously expressed and are associated with small RNAs. The structure, function and role of the AGO proteins in the cell is discussed in detail.
Pyridoindole SMe1EC2 as cognition enhancer in ageing-related cognitive decline
Authors: Mrvová Nataša , Škandík Martin , Bezek Štefan , Sedláčková Natália , Mach Mojmír , Gaspárová Zdenka , Luptáková Dominika , Padej Ivan , Račková Lucia 
Published: February 2018

Abstract
Synthetic pyridoindole-type substances derived from the lead compound stobadine represent promising agents in treatment of a range of pathologies including neurological disorders. The beneficial biological effects were suggested to be likely associated with their capacity to ameliorate oxidative damage.
In our study, the effect of supplementation with the derivative of stobadine, SMe1EC2, on ageing-related cognitive decline in rats was investigated. The 20-months-old male Wistar rats were administered SMe1EC2 at a low dose, 0.5 mg/kg, daily during eight weeks. Morris water maze test was performed to assess the spatial memory performances. The cell-based assays of capacity of SMe1EC2 to modulate proinflammatory generation of oxidants by microglia were also performed.
The rats treated with SMe1EC2 showed significantly increased path efficiency, significantly shorter time interval of successful trials and exerted also notably lower frequencies of clockwise rotations in the pool compared to non-supplemented aged animals. Mildly improved parameters included test durations, distances to reach the platform, time in periphery of the pool and overall rotations in the water maze. However, the pyridoindole SMe1EC2 did not show profound inhibitory effect on production of nitric oxide and superoxide by activated microglial cells.
In conclusion, our study suggests that pyridoindole SMe1EC2, at low doses administered chronically, can act as cognition enhancing agent in aged rats. The protective mechanism less likely involves direct modulation of proinflammatory and prooxidant state of microglia, the prominent mediators of neurotoxicity in brain ageing and neurodegeneration.
Melatonin protects against chromium (VI) induced hepatic oxidative stress and toxicity: Duration dependent study with realistic dosage
Authors: Banerjee Sudip , Joshi Niraj , Mukherjee Raktim , Singh Prem Kumar , Baxi Darshee , Ramachandran A.V. 
Published: February 2018

Abstract
The present study was undertaken to assess the degree of oxidative stress and toxic effects induced by chromium on hepatic tissue in male Wistar rats exposed to a realistic dosage of Cr(VI) (20 mg/kg/b.w./day) through drinking water, based on the levels of these metals found in the environment, for a duration of 15, 30 and 60 days. The protective effect of melatonin (10 mg/kg) was also studied by simultaneous administration with the metal. Levels of enzymatic and non-enzymatic antioxidants as well as lipid peroxidation were assessed. There was a significant decrease in enzymatic as well as non-enzymatic antioxidants and an increase in the lipid peroxidation level, which were prevented and maintained at near-normal levels by the administration of melatonin in all treatment periods. Metal accumulation was maximal at 15 days, with gradual decreases till 60 days. Histopathological observations also demonstrated the fact that Cr (VI) exposure leads to cytological lesions in the hepatic tissue promoting cellular necrotic/apoptotic changes, while melatonin was able to counteract insults induced by Cr (VI) at all treatment periods. It also prevented alterations in insulin and glucose levels. Overall, the present study suggests a duration-dependent effect of Cr on hepatic oxidative stress and cytotoxicity and shows the potent activity of melatonin in preventing the negative effects of Cr (VI).
Deleterious effects of combination of lead and β-amyloid peptides in inducing apoptosis and altering cell cycle in human neuroblastoma cells
Authors: Neelima Ayyalasomayajula , Rajanna Ajumeera , Bhanuprakash Reddy G. , Chetty C.S. , Suresh Challa 
Published: February 2018

Abstract
Lead (Pb) is a toxic pollutant known to cause several abnormalities related to the brain, including cognitive dysfunction, and it is ubiquitous in nature. β-amyloid peptides (AP) are crucially involved in Alzheimer’s disease (AD). It has been reported that there is a connection between lead and amyloid peptides in exerting similar kinds of altered functions in the brain and long-term exposure to lead leads ultimately to increased beta amyloid formation in the brain, lethal to human brain cells. There is still a lack of information on the mechanism by which Pb affects AP formation, exerting combined toxicity in AD patients. To fill the gap, we have systematically analyzed the toxicity individually and in combination of Pb and AP in human brain cells. We found that the combination of Pb and AP exerted a higher toxicity than individual exposures in human neuroblastoma cells. The lower inhibitory concentration values were determined by both time and concentration dependent manner on using MTT assay. The data resulted in the development of enhanced toxicity on exposure to Pb with both the combinations of AP(1-40) or (25-35) and with all combinations in human brain cells compared to individual exposures to Pb (1-40) or AP(25-35). The severe apoptotic effect and alteration in cell cycle by arresting at the S-phase evidenced the increased toxicity of combinational exposure to Pb and AP on human neuroblastoma cells. Furthermore, the quantitative determination of LDH and caspase-3 activity indicated the induction of severe toxicity. We conclude that both are synergistically associated with effects such as arresting the cell cycle and triggering apoptosis during the progression of Alzheimer’s disease.
Chronic exposure to quinalphos shows biochemical changes and genotoxicty in erythrocytes of silver barb, Barbonymus gonionotus
Authors: Sadiqul Islam M. , Kabir Saimon Mohiful , Ferdous Zannatul , Mansura Khan Mst. , Khalilur Rahman Md. 
Published: February 2018

Abstract
An in vivo study was carried out on the freshwater fish Barbonymus gonionotus to evaluate the genotoxic effects of the organophosphate quinalphos. The fish were exposed to sub-lethal doses of quinalphos (0%, 10%, 25%, and 50% of LC50) for a period of 30 days. Analysis of biochemical characteristics (protein and lipid contents of different organs), nuclear abnormalities of erythrocytes (NAE) and morphological abnormalities of erythrocytes (MAE) were performed on peripheral erythrocytes sampled at post-treatment intervals of 0 and 30 days. The biochemical results revealed a significant dose-dependent decline in protein and lipid contents and increase in the frequencies of NAE as well as MAE. Our findings also confirmed that the morphological deformations of erythrocytes in addition to NAE on fish erythrocytes in vivo are effective tools in determining the potential genotoxicity of organophosphates.
Aflatoxins and Health Considerations in Consumer Food Choices in Ghana
Authors: Agyekum Michael , Jolly Curtis M. , Thompson Henry 
Published: February 2018

Abstract
Food safety enjoys sustained attention among the scientific community, policymakers, and the general public due to health impacts. However, pursuing appropriate regulations for pervasive food contaminants is a challenging policy issue, particularly for naturally-occurring food toxins such as aflatoxins and other mycotoxins. This paper explores consumer preferences for quality aflatoxin-free peanuts, and how food safety concerns may impact willingness to pay more for safer foods. Incorporating ‘risky’ foods into random utility-maximization framework, we analyze contingent valuation survey data on Ghana. Model and survey results show consumers in Ghana approve of food aflatoxin regulations, and are prepared to pay price premiums as incentives to ensure supply of quality peanuts. Findings reveal that consumers prioritize food safety above prices in market decisions. People prefer introduction of aflatoxin regulations that would guarantee good health; useful information for policy makers in Ghana, Africa, and rest of the developing world.
Performance Analysis of Laser Phase Noise Compensated COOFDM System
Authors: Dhawan Divya , Gupta Neena 
Published: February 2018

AbstractOrthogonal Frequency Division Multiplexing along with the coherent detection and spectrally efficient modulation formats is a promising solution for long haul and high speed communication systems. Although they offer significant advantages which make them suitable for high speed and long haul communication systems they all are susceptible to phase noise. In this paper a combination of RF-pilot-based approach followed by pilot-based equalization approach is used for laser phase noise compensation. The various parameters such as drive voltage, bias voltage and extinction ratio are optimized to get the optimum performance from the proposed scheme. The designed system is then analyzed in terms of Symbol Error Rate (SER), constellation diagrams and error vector magnitude using various types of Quadrature Amplitude Modulation (QAM) formats.