bluuebunny/crossref_metadata_2025_split huggingface dataset:
The COMMAND trial of cognitive therapy for harmful compliance with command hallucinations (CTCH): a qualitative study of acceptability and tolerability in the UK
Authors: Birchwood Max , Mohan Laura , Meaden Alan , Tarrier Nick , Lewis Shon , Wykes Til , Davies Linda M , Dunn Graham , Peters Emmanuelle , Michail Maria 
Published: June 2018

ObjectivesTo explore service user experiences of a 9-month cognitive behavioural therapy for command hallucinations in the context of a randomised controlled trial including their views on acceptability and tolerability of the intervention.DesignQualitative study using semistructured interviews.SettingThe study took place across three sites: Birmingham, Manchester and London. Interviews were carried out at the sites where therapy took place which included service bases and participants’ homes.ParticipantsOf 197 patients who consented to the trial, 98 received the Cognitive Behavior Therapy for Command Hallucinations (CTCH) intervention; 25 (15 males) of whom were randomly selected and consented to the qualitative study. The mean age of the sample was 42 years, and 68% were white British.ResultsTwo superordinate themes were identified: participants’ views about the aspects of CTCH they found most helpful; and participants’ concerns with therapy. Helpful aspects of the therapy included gaining control over the voices, challenging the power and omniscience of the voices, following a structured approach, normalisation and mainstreaming of the experience of voices, and having peer support alongside the therapy. Concerns with the therapy included anxiety about completing CTCH tasks, fear of talking back to voices, the need for follow-up and ongoing support and concerns with adaptability of the therapy.ConclusionsInterpretation: CTCH was generally well received and the narratives validated the overall approach. Participants did not find it an easy therapy to undertake as they were challenging a persecutor they believed had great power to harm; many were concerned, anxious and occasionally disappointed that the voices did not disappear altogether. The trusting relationship with the therapist was crucial. The need for continued support was expressed.Trial registration numberISRCTN62304114, Pre-results.
Unique percutaneous direct puncture technique for occlusion of a hypoglossal canal dural arteriovenous fistula
Authors: Diaz Orlando M , Toledo Maria M , Roehm John O F , Klucznik Richard P , Chinnadurai Ponraj , Lopez Gloria Viviana , Britz Gavin W 
Published: June 2018

PurposeTo report percutaneous transcranial puncture, embolization and occlusion of a very symptomatic hypoglossal canal/anterior condylar vein dural arteriovenous fistula (DAVF) using syngo iGuide navigational software in a patient in whom transarterial and transvenous embolization and surgery had failed.MethodsAfter unsuccessful arterial and venous embolization and surgical treatment of a symptomatic hypoglossal canal DAVF, a 47-year-old man was transferred for further management. With exquisite anatomic detail provided by C-arm cone-beam computed tomography (CBCT) equipment (Artis zee Biplane, Dyna CT VC21H, Siemens Healthcare GmbH, Germany) and syngo iGuide needle guidance navigational software (Siemens Healthcare GmbHy) for planning a safe direct approach, the hypoglossal/anterior condylar vein, the dominant outflow vein of the fistula, was needle punctured percutaneously at the hypoglossal foramen and occluded with ethylene vinyl alcohol copolymer liquid embolic agent (Onyx, Medtronic, Minneapolis, Minnesota, USA) after placing two anchoring platinum coils (Target detachable coils, Stryker Neurovascular, Fremont, California, USA).ResultsAfter a year of progressively severe left eye proptosis, chemosis and increased intraocular pressure, the symptoms quickly subsided after this embolization and the patient was symptom free at his 3-month and later checkups.ConclusionWith guidance and imaging provided by CBCT and syngo iGuide navigational software, an otherwise untreatable DAVF was successfully embolized and obliterated by an aggressive unique percutaneous trans-cranial needle puncture of the dominant outflow vein in the hypoglossal canal.
Aortic Arch Width and Cardiovascular Disease in Men and Women in the Community
Authors: Chuang Michael L. , Gona Philimon N. , Qazi Saadia , Musgrave Rebecca M. , Fox Caroline S. , Massaro Joseph M. , Hoffmann Udo , O'Donnell Christopher J. 
Published: June 2018

Background

We sought to determine whether increased aortic arch width (
AAW
) adds to standard Framingham risk factors and coronary artery calcium (
CAC
) for prediction of incident adverse cardiovascular disease (CVD) events in community‐dwelling adults.

Methods and Results

A total of 3026 Framingham Heart Study Offspring and Third Generation cohort participants underwent noncontrast multidetector computed tomography from 2002 to 2005 to quantify
CAC
. We measured
AAW
as the distance between the centroids of the ascending and descending thoracic aorta, at the level of main pulmonary artery bifurcation or the right pulmonary artery. We determined sex, age group, and body size specific cut points for high (≥90th percentile)
AAW
from a healthy referent group (N=1471) and dichotomized
AAW
as high or not high across all study participants. Clinical covariates were obtained at Offspring cycle 7 (1998–2001) or Third Generation cycle 1 (2002–2005) examinations. The primary CVD outcome was a composite of myocardial infarction, coronary insufficiency, cerebrovascular accident, first hospitalization for heart failure, or CVD death. Cox proportional hazards models were used to estimate hazard ratio of high
AAW
on time‐to‐incident
CVD
after adjustment for Framingham risk factors and
CAC
. Net reclassification improvement was used to assess the effect of adding
AAW
to the baseline Framingham risk factor+
CAC
model. A total of 2826 participants (aged 51±11 years, 48% women) had complete covariates and were free of
CVD
at multidetector computed tomography. Over a median 8.9 years of follow‐up, there were 135 incident
CVD
events. High
AAW
was independently predictive of
CVD
events (hazard ratio, 1.55;
P
=0.032) and appropriately reclassified participants at risk: net reclassification improvement, 0.31 (95% confidence interval, 0.15–0.48).

Conclusion

AAW
augments traditional
CVD
risk factors and
CAC
for prediction of incident adverse
CVD
events among community‐dwelling adults.
CD4+ Foxp3+ regulatory T cell-mediated immunomodulation by anti-depressants inhibiting acid sphingomyelinase
Authors: Schneider-Schaulies Jürgen , Beyersdorf Niklas 
Published: June 2018

Abstract
Acid sphingomyelinase (ASM) is the rate-limiting enzyme cleaving sphingomyelin into ceramide and phosphorylcholin. CD4+ Foxp3+ regulatory T (Treg) cells depend on CD28 signaling for their survival and function, a receptor that activates the ASM. Both, basal and CD28-induced ASM activities are higher in Treg cells than in conventional CD4+ T (Tconv) cells. In ASM-deficient (Smpd1
−/−) as compared to wt mice, membranes of T cells contain 7–10-fold more sphingomyelin and two- to three-fold more ceramide, and are in a state of higher order than membranes of T cells from wt mice, which may facilitate their activation. Indeed, the frequency of Treg cells among CD4+ T cells in ASM-deficient mice and their suppressive activity in vitro are increased. Moreover, in vitro stimulation of ASM-deficient T cells in the presence of TGF-β and IL-2 leads to higher numbers of induced Treg cells. Pharmacological inhibition of the ASM with a clinically used tricyclic antidepressant such as amitriptyline in mice or in tissue culture of murine or human T cells induces higher frequencies of Treg cells among CD4+ T cells within a few days. This fast alteration of the balance between T cell populations in vitro is due to the elevated cell death of Tconv cells and protection of the CD25high Treg cells by IL-2. Together, these findings suggest that ASM-inhibiting antidepressants, including a fraction of the serotonin re-uptake inhibitors (SSRIs), are moderately immunosuppressive and should be considered for the therapy of inflammatory and autoimmune disorders.
Sphingolipids in inflammatory hypoxia
Authors: Glaser Ulrike G. , Fandrey Joachim 
Published: June 2018

Abstract
Hypoxia due to rapid tumor growth with impaired neovascularization and inflammation resulting from immune cell activation are hallmarks of cancer. Hypoxia-inducible factors control transcriptional adaptation in response to low oxygen conditions, both in tumor and immune cells. In addition, sphingolipids become increasingly recognized as important cell mediators in tumor and inflammatory hypoxia. Recent studies have identified acid sphingomyelinase (ASM), a central enzyme in the sphingolipid metabolism, as a regulator of several types of stress stimuli pathways and an important player in the tumor microenvironment. Therefore, this review will address the connection between the hypoxic response and the ASM/ceramide system in the context of inflammatory hypoxia.
Sphingolipid metabolism – an ambiguous regulator of autophagy in the brain
Authors: van Echten-Deckert Gerhild , Alam Shah 
Published: June 2018

Abstract
In mammals, the brain exhibits the highest lipid content in the body next to adipose tissue. Complex sphingolipids are characteristic compounds of neuronal membranes. Vital neural functions including information flux and transduction occur along these membranes. It is therefore not surprising that neuronal function and survival is dependent on the metabolism of these lipids. Autophagy is a critical factor for the survival of post-mitotic neurons. On the one hand, it fulfils homeostatic and waste-recycling functions and on the other hand, it constitutes an effective strategy to eliminate harmful proteins that cause neuronal death. A growing number of experimental data indicate that several sphingolipids as well as enzymes catalyzing their metabolic transformations efficiently but very differently affect neuronal autophagy and hence survival. This review attempts to elucidate the roles and mechanisms of sphingolipid metabolism with regard to the regulation of autophagy and its consequences for brain physiology and pathology.
Ausgabenpolitik
Authors: Jaspers Anke 
Published: June 2018

AbstractFrom a publishing perspective, a literary work is always manifested in a variety of issues. The article reconstructs the production history of the early editions of the East German author Angela Krauß in the West German Verlag at the time of the German division. It illustrates how the publishing house is involved in the configuration of a work in its processuality and unity. The article then explains the historical significance of West German issues for East German authors as means of extending their scope of action in the GDR. The focus on issues allows insights into concrete production processes of literature and their historical reception to be gained.
Theorieübersetzungen
Authors: Paul Morten 
Published: June 2018

AbstractThe article follows the trajectory of two books by French philosopher Jacques Derrida through the German publishing scene, from their early rejection to their eventual release with the now-famous Suhrkamp Verlag. In the process, it casts a light on the particular role foreign philosophy has played in the establishment of the Suhrkamp Verlag as a publishing house for the humanities. In turn, this enables new perspectives on the formation of the canon of what is today generally referred to as ‘theory’. Attention to translational practices in their extended sense becomes a central analytical tool for gaining insights into the concrete production processes of theory and their social, economic, and political conditions.
Core-shell Fe-SiO2-polyamine magnetic nanoparticles for metal recovery using a continuous flow pipeline reactor
Authors: Deluca Emile , Latterman Ryan , Rosenberg Edward 
Published: June 2018

Abstract
A series of core-shell magnetic nanomaterials have been synthesized with the intent of applying them for metal ion capture in a newly designed pipeline reactor. The synthetic chemistry is an extension of a previously developed family of materials based on amorphous silica gel, which has been used in the mining and remediation industries. The nanoparticles were characterized by infrared spectroscopy and TEM and SEM techniques. The size of the starting magnetite core was critical to the behavior of the particles under metal sequestering conditions. The capture kinetics of the resulting nanoagregates is 10 times faster than related micro composites. All of the tests performed point to the future successful development of a technology that circumvents the disadvantages associated with the use of column based microparticles.
The correct symmetry of the six-fold twin in β-Ca11B2Si4O22
Authors: Nespolo Massimo 
Published: June 2018

Abstract
A recently reported six-fold twin in β-Ca11B2Si4O22 was interpreted as a transformation twin obtained during cooling of a hypothetical hexagonal high temperature phase. The suggested dichromatic symmetry of the twin is incorrect because (1) a six-fold twin cannot be represented by a dichromatic twin point group but by a hexachromatic group; (2) the reported dichromatic group does not exist. The correct hexachromatic twin point group is reported here.
Exoticism, Cultural Hybridity, and Subaltern Identity in Three Macanese Novels
Authors: Suárez José 
Published: June 2018

Although the novels of Austin Coates, Henrique de Senna Fernandes, and Rodrigo Leal de Carvalho’s depict life in the former Portuguese colony of Macau, their individual perspectives reflect a contrast between literary colonialism and coloniality. A British public servant, Coates perceives Macanese reality through the competing biased eyes of an Englishman resenting Portuguese culture and administration in the colony; Leal de Carvalho, a Portuguese resident of Macau, romantically depicts the social nature of Portuguese colonialism; Senna Fernandes, a native Macanese educated in Portugal, orders his interpretation of the colony’s Eurasian inhabitants vis-à-vis its Chinese population. The aim of this article is to contrast the literary representation of three issues in Coates’s City of Broken Promises, Fernandes’s The Bewitching Braid, and Carvalho’s The Count and his Theree Wives: exoticism, cultural hybridity, and subaltern identity.
O conceito de 'retornado' e a representação da ex-metrópole em O Retorno e Os Pretos de Pousaflores
Authors: Ferreira Patrícia Martinho 
Published: June 2018

Following the trajectories of the families featured in the novels O Retorno (2011), by Dulce Maria Cardoso, and Os Pretos de Pousaflores (2011), by Aida Gomes, this essay aims to problematize the meaning retornado and understand how the label evokes contradictory feelings and conceptions regarding the Portuguese colonial experience. I also reflect on the complex process of the integration of retornados into post-colonial Portuguese society. Finally, I analyze the text’s representation of the former metropole and its ambivalent role in the construction of identity undertaken by these narrators.
Urban Planning Terminology in Albanian and Foreign Languages
Authors: Papamihali Eva 
Published: June 2018

Abstract
The following article aims to introduce a scientific work undertaken with the aim of producing an Urban Planning terminology Dictionary in Albanian, accompanied by French and English. The study and exposure of urban planning terminology will be treated in two works, part of one another: *The theory platform for the analyses of linguistic problems represented by this terminology. *The draft of a dictionary with the main urban planning terminology (Albanian - French - English). To accomplish these two works, a preparatory work has been done in the first stage as it follows: 1. A great quantity of urban planning terms has been taken from this branch’s literature (schoolbooks; books published by urban planners about the various urban problems; this branch’s periodical magazines; urban laws throughout the years alongside with the relevant regulations; etc) what makes up the factual material. 2. The theory material has been collected and studied and it includes monographs, articles, references and other editions which have dealt with Albanian terminology problems, obviously by Albanian authors. We have also used foreign literature about terminology problems, mainly in French. On this theory and factual bases and by following the scientific criteria which have been applied to draft the terminology dictionaries (Albanian - Foreign languages) by the terminology section of the Albanian language and literature Institute, we have launched the preliminary wordy of the dictionary and partially completed its equivalent in French. While working with this dictionary, we have begun dealing with one terminology problem which is used in this branch, the one of the meaning phenomena. During this whole process, there urged the need to complete the factual material and naturally to deeply exploit the theory literature.
Particularities of occupational health and safety management in the police environment
Authors: Achim Adrian-Constantin 
Published: June 2018

Abstract
To other professions, in law enforcement, due to the diversity and complexity of police activity, policemen are daily exposed to various dangers resulting from the risky nature of their working environment. Thus, police work must be carried out in the most aggravating circumstances, often with limited staff and only having a few seconds to make critical decisions: whenever using the legal means, specific equipment, intercepting or immobilizing offenders, acting against various violations of the law, police officers are exposed to a very high number of occupational risks, compared to other civil professions. Despite the fact that public security environment risks are constantly evaluated by specialized workers and dedicated tools, compared to the policeman, this activity almost does not happen and it is mostly evasive taking into consideration that this area is within the competence of the high level manager and it is conducted by the human resources structures in the police units. Although this approach is totally wrong, these entities are the only ones in charge of controlling, mitigating or eliminating work related risks generated by police activity. This paper makes a brief assessment of the risks associated with the police operational work, taking into account the indicators taken and analyzed from the existing statistics of the Romanian Ministry of Internal Affairs, while offering new solutions in mitigating risks concerning the physical security of police workers.
The significance and managerial challenges of virtual teamworking
Authors: Al Zain Nora-Labiba , Vasilache Simona , Incze Cynthia Bianka 
Published: June 2018

Abstract
Living in a world where technology has evolved in an alarming pace, the working structures have become more diverse adapting to this trend, and giving birth to virtual teams, thanks to the ITC tools that have broken the physical boundaries, allowing coworkers to connect from all corners of the world and construct together. The aim of the article is to enrich the effectiveness of virtual teams but also acknowledge the difficulties they may run into throughout their project completions. Mixed methodology was chosen for the study case, having the Romanian Tourism Heritage Federation members as the sample of the survey. The quantitative method was used to quantify the data offered by the surveyed candidates and offer a deeper insight, by collecting data regarding certain aspects of the candidate such as: age, education and experience level, online “literacy”, size and role of the team member etc. and presented in a well-structured figure table. Whereas, the qualitative method concentrated on obtaining beneficial data regarding aspects as: cultural and technological barriers, trust and team commitment barriers along with social interaction ones, as well as leadership and team dynamics perspective. The findings of the research were gathered, interpreted and presented briefly, giving a comprehensive image of the “virtual team” nowadays, facing both fruitful and challenging traces in their working style.
A theoretical review on the structural convergence issue and the relation to economic development in integration areas
Authors: Alexoaei Alina Petronela , Robu Raluca Georgiana 
Published: June 2018

Abstract
The aim of the paper is to provide a consistent literature review on the importance of structural convergence for the countries within the same economic area focusing on two main topics: the structural similarity problem of countries within an integration area and the evolution and development of the union itself (in line with Chenery and Singer’s approach). We aim to synthesize the most referential findings of the literature and project them on the most recent events in the European Union pointing out the relevance of structural convergence and of the continuation of the process under a reassessed form. The relevance of studying the structural convergence process lies in the medium and long term implications related to the synchronization of business cycles, long-run development patterns and of the dynamics of specialization. Moreover, the topic is of high interest both in the context of the future evolution of the European Union and in the decision making process of adopting the Euro in Romania’s case. On the side of theoretical papers, there is a rich literature on structural change that generally recommends that economic structures and the differences between them should be the starting point for analysis and development of theories of economic development. We believe that the preoccupations for this topic should be recalled in the context of the European events and new facets should be explored. Along with the views expressed in the European Commission White Paper, that the form will follow the function, we emphasize the importance of designing the proper institutions at European Union and Eurozone level, but also at national level with taking into consideration the goal of advancing towards structural convergence.
Analysis of social models in Central and Eastern Europe - A focus on poverty and social exclusion
Authors: Argatu Ruxandra 
Published: June 2018

Abstract
In the present context, defined by a variety of social changes, social advancement is a key point that needs to be sheltered and ensured both in Romania as well as at the level of the European Union, in order to have a coherent European space, to reach and maintain a high level of social and economic welfare. The improvement of the social domain can be triggered by using the principles of the European Social Model, which incorporates values and institutions specially established to protect the integrity of people who are socially disadvantaged. Thus, the paper aims, on one hand, to analyze literature review aspects of the European Social Model as being a social development one and to identify the criteria according to which progress is established in relationship with this model. On the other hand, another goal of the paper is to make a comparative analysis between Romania's performance in the context of Central and Eastern European countries' situation. The purpose of the analysis is to diagnose the progress recorded and the social area in which it took place, as well as the differences between countries. The focus of the analysis will be placed on poverty and social exclusion, as dimensions of the European Social Model. The methodology that will help in undertaking the research comprises two elements: literature review and document analysis. The literature review component involves pinpointing information obtained from scientific articles about the European Social Model and aspects associated with it, available in online databases. The second part of the methodology refers to document analysis, which supposes the assessment of reports issued by organizations that provide such statistical data (Eurostat, World Bank, Social Progress Imperative).