bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accordance of Indocyanine Green Angiography and Optical Coherence Tomography Angiography in Visualization of Neovascularization Associated with Chronic Central Serous Chorioretinopathy
Authors: Pedanova E. K. , Klepinina O. B. , Buryakov D. A. 
Published: July 2018

Purpose: to compare informativity and accordance of indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCT-A) data in visualization of neovascularization associated with chronic central serous chorioretinopathy. Patients andMethods. Twenty one eye of 21 patients (aged 51.0 ± 8.4 years old) with chronic central serous chorioretinopathy (CSR) and assumed choroidal neovascularisation (CNV) with «double layer» sign on optical coherence tomography scans were enrolled in this study. ICGA on Spectralis HRA+OCT, (Heidelberg Engeneering, Germany) and OCT-A on RTVue XR Avanti (Optovue, USA) were performed to evaluate CNV. The assessment of obtained pictures was examined by two experts.Results. Both diagnostic methods have shown similar results. CNV has been revealed in 11 of 21 eyes by ICGA imaging while OCT-A confirmed neovascularization in 13 eyes — with no statistical difference between methods (p = 0.74, χ2). CNV has not been diagnosed in 10 cases by ICGA and in 8 cases by OCT-A (p = 0.69). However, the consistency of the two methods in CNV evaluation while pairwise comparison of angiography data has been confirmed only in 8 eyes. The absence of CNV has been confirmed in 6 eyes — mostly in patients with CSR recurrence. One third of patients (7 of 21 eyes) have not shown consistence of two methods. The OCT-A visualization of CNV could be poor because of subretinal deposits and pigment-related signal blocking. In cases of diffuse retinal pigment epithelium atrophy the neovascular network cannot been seen on ICGA images while well visualized on OCT-A.Conclusion. The informativity of ICGA and OCT-A in visualization of neovascularization associated with chronic central serous chorioretinopathy is similar. For the best data interpretation the condition of neurosensory retina and pigment retinal epitheluium should be taken into account. OCT-A is more preferable in cases of diffuse epitheliopathy, while the neovascularization activity and leakage points is better seen on ICGA.
Prediction Model for Determination of Indications for Laser or Surgical Treatment for Aggressive Posterior Retinopathy of Prematurity at the Manifestation Stage
Authors: Tereshhenko A. V. , Trifanenkova I. G. , Sidorova Yu. A. , Tereshhenkova M. S. , Erohina E. V. , Isaev S. V. 
Published: July 2018

The purpose: to analyze anthropometric and diagnostic parameters in children with aggressive posterior ROP at the manifestation stage on its basis to build a predictive model, which allows to determine the indications for laser or surgical treatment.Patients and methods. The study included 111 children (190 eyes) with aggressive posterior ROP at the manifestation stage. 67 children (134 eyes) underwent transpupillary retinal laser photocoagulation (LPC) in the period from 2008 to 2013. In 46 children (82 eyes) the disease regression was archived (group 1), in 31 children (52 eyes) the progression continued (group 2), so at the second stage early lens-sparing vitrectomy was performed (2–4 weeks after LPC). In 34 children (56 eyes) primary lens-sparing vitrectomy was performed in the period from 2013 to 2017 (group 3). Anthropometric and diagnostic data for all patients were subjected to statistical analysis for building a predictive model.Results. The predictive model was based on logistic regression that determines the probability of separation of children with aggressive posterior ROP to the manifestation stage on treatment methods: transpupillary LPC or primary vitrectomy. The following parameters were selected: the diameter of the central arteries and tortuosity index (TI). All groups were joined into a single array to create the model, which allowed to differentiate the patients according to the treatment types based on the input data processing. It was obtained the equation of the logistic regression: Z = exp(55,2726 – 0,1584X – 35,3911Y) / (1 + exp(55,2726 – 0,1584X – 35,3911Y)), where Z has the value from 0 to 1.0; X value is the diameter of the central artery of the patient; Y — the value of the TI arteries of the patient. If Z < 0.5, then the patient has indications for surgical treatment, if Z > 0.5 — for laser treatment.Conclusion. The predictive model was obtained that with a probability of 96% allows to determine objectively the optimal treatment method for children with aggressive posterior ROP at the manifestation stage of the disease: transpupillary LPC or primary vitrectomy. This will increase the effectiveness of treatment of the severe and prognostically unfavourable forms of ROP. This model can be a “working” tool for ophthalmologists involved in the treatment of ROP, its introduction into the clinical practice is advisable.
Differentiated Approach to the Surgical Treatment of Chronic Uveitis in Juvenile Idiopathic Arthritis
Authors: Tereshchenko A. V. , Trifanenkova I. G. , Tereshchenkova M. S. , Erokhina E. V. , Yudina N. N. 
Published: July 2018

The purposeis to analyze the results of complex treatment of chronic uveitis in juvenile idiopathic arthritis.Patients and methods. The study included 26 children (46 eyes) with uveitis associated with JIA aged from 5 to 16 years. All children underwent a comprehensive ophthalmological examination. The patients were divided into 3 groups. The first group included children with anterior uveitis (18 eyes), 3 eyes had iridocyclitis without changing of optical media transparency; precipitates on the endothelium in combination with the rear adhesions and complicated cataract were revealed in 15 eyes. The second group included children with middle and posterior uveitis (12 eyes), where effusion into the vitreous in combination with retinal edema in macular area were shown. The third group included children with panuveitis (16 eyes), where ribbon-like corneal dystrophy in combination with the rear adhesions, complicated cataract, and pericardial effusion of varying severity in the vitreous body traction syndrome, macular edema were revealed. Treatment tactics in each group depended on the characteristics of the pathological process.Results. In the first group, visual acuity in the postoperative period was 0.5–0.8. In the second group, after the conservative drug anti-inflammatory treatment, the pathological process subsided and visual acuity increased up to 0.6–0.8 in 4 eyes. In 3 eyes with a pronounced traction component on the periphery and the presence of vitreomacular traction syndrome, where vitrectomy was performed, visual acuity was 0.3–0.5. After intravitreal “Ozurdex” implantation (5 eyes), diffuse macular edema decreased and visual acuity increased up to 0.7–0.8. In the third group, in cases of intense opacity of the vitreous body due to exudative effusion, a 3-port 25–27G vitrectomy with silicone oil tamponade was performed. Visual acuity after the surgery varied from 0.2 to 0.5.Conclusion. High functional results in children with uveitis associated with JIA were achieved due to modern methods of preoperative diagnosis, advanced surgical techniques, as well as proper management of the patients in the postoperative period.
Undenatured collagen type II for the treatment of osteoarthritis: a review
Authors: Prabhoo Ram , Billa Gauri 
Published: July 2018

<p class="abstract">Osteoarthritis is a prevalent musculoskeletal condition worldwide with rising rates in elderly people. Both mechanical and immunological factors are implicated in the pathogenesis of osteoarthritis resulting in destruction of the articular cartilage. Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used for the treatment of osteoarthritis, are associated with several adverse events and also do not affect the underlying disease process. Clinicians and patients both seek options which are safe and effective in the treatment of osteoarthritis. Collagen derivatives represent a suitable option in such cases. Collagen is the most abundant component of the cartilage. Collage derivatives have shown to have disease modifying action in osteoarthritis. Depending on the degree of hydrolysis and molecular weight, collage derivatives are classified into undenaured collagen, gelatin and collage hydrolysate. Collagen derivatives are well tolerated without major safety concerns. Undenatured type II collagen has shown to provide significant improvement in patients with osteoarthritis. In this article we discuss, the pathophysiology of osteoarthritis with focus on immunological factors and evidence for the use of undenatured collagen type II in osteoarthritis.</p><p class="abstract"> </p>
Impacto de un relato sobre las percepciones de racismo y sexismo en escolares de Primaria
Authors: Mateos-Jiménez Antonio , Torres-Martínez Belén , García-Fernández Beatriz 
Published: July 2018

Las discriminaciones por etnia, cultura y sexo siguen presentes en nuestra sociedad y a menudo se interconectan. La escuela es un lugar fundamental para educar en las competencias en interculturalidad e igualdad entre sexos. El objetivo de esta investigación es comprobar si un relato elaborado ad hoc puede considerarse un recurso didáctico útil para trabajar ambas discriminaciones. Se presenta un estudio de caso en el que se han identificado las percepciones de un grupo de estudiantes sobre el racismo y el sexismo. Para ello se aplicó un cuestionario antes y después de una intervención de aula, empleando la narración. La muestra se compuso de 111 escolares de 3º a 6º de Educación Primaria. Los resultados indican que los participantes modificaron sus percepciones y mejoraron sus ideas sobre la no discriminación en los dos ámbitos, sin diferencias significativas entre sexos. Se discute el interés didáctico de la narración empleada y su novedad como texto integrador de varios valores y contenidos. Se aboga por la necesidad de formar docentes capaces de trabajar la competencia intercultural y el género.
OVERVIEW OF ELECTROMAGNETIC INTERFERENCE ISSUES IN AIRCRAFT
Authors: Kumar Abhishek 
Published: July 2018

Purpose of Study: In the modern era, due to several conflictions or uncertainty in the aircraft, Electromagnetic Interference (EMI) or Radio Frequency Interference (RFI) issues occurred, frequently. The main reason behind it several disturbances generated by an external source that imitate wireless circuits with the help of conduction, electrostatic coupling, and electromagnetic induction. These disturbances may decrease the performance of the circuits or sometimes fully stop the operations.
Methodology: The main challenges in EMI are modeling and simulation for modern and future wireless communication systems and networks taking into account nonlinear interference effects.
Result: In this paper, overviews of several issues of EMI or RFI are illustrated.
Trisiklik Antidepresan Zehirlenmelerinde Adora Risk Skorlaması
Authors: Aydın Macit , Yardan Türker , Baydın Ahmet , Genç Selim 
Published: July 2018

Amaç: Trisiklik antidepresan (TSA) zehirlenmeleri ciddi klinik sonuçlara neden olabilir. TCA zehirlenmesi olan hastaların değerlendirilmesinde “Antidepresan Doz Aşımı Risk Değerlendirmesi” (ADORA) kriterleri kullanılmıştır. Bununla birlikte, bu kriterlerin klinik uygulamadaki yararları hakkındaki veriler, ADORA kriterlerini doğrulamak için yetersizdir. Bu çalışmanın amacı, ADORA kriterlerinin klinik sonuç ile ilişkisini belirlemektir. Gereç ve Yöntem: Çalışmaya yıllık toplam 133 hasta dahil edildi. Hastalar ADORA kriterlerine göre yüksek risk ve düşük risk gruplarına ayrıldı. Bulgular:Ortanca yaş 25 (18-55 yaş aralığında) idi. Hastalar genellikle TCA ajanı olarak amitriptilin kullanmışlardır. En sık görülen semptomlar kuru deri, kusma ve midriyazis idi. Risk sınıflandırmasına göre; Hastaların %59.4'ü yüksek risk grubunda idi. En sık görülen bulgular sağ aks sapması ve aVR de R&gt;S bulgusu idi. ADORA kriterlerine göre 79 hasta (n=%59,4) yüksek risk grubunda idi. Hastaların tümü komplikasyonsuz taburcu edilmişti. ADORA pozitif risk skor sayısı arttıkça yatış süresi, QTc uzunluğu ve nöbet sıklığı artmaktaydı.Sonuç:ADORA kriterleri, TCA zehirlenmesinin değerlendirilmesi ve klinik takibinde faydalıdır.
<p>Cyber-supported Professional Learning Experiences that Build Technology
and Engineering Educators’ Practice</p>
Authors: Ernst Jeremy , Clark Aaron , Bowers Sharon 
Published: July 2018

Educational changes due to school reform and the introduction of new national
standards create a need for professional learning experiences for STEM (Science,
Technology, Engineering, and Mathematics) educators that are results-driven, easily
accessible, and aligned with identified best practices (National Research Council, 2009;
National Staff Development Council, 2001). This need, specifically addressing technology
and engineering educators, generated the development and delivery of the Transforming
Teaching through Implementing Inquiry (T2I2) project. Within the T2I2 development stage,
learning objects were created to introduce, reinforce, and broaden technology and
engineering educators’ conceptual content and pedagogical content knowledge to inform
and impact their personal teaching practice. To deliver this instruction, a cyber
infrastructure was created to support content development, assessment, community
building, and cyber-coaching. This field study followed the methodology established
within T2I2’s two-year pilot study (Ernst, Segedin, Clark, & DeLuca, 2014),
selecting participants from the identified five-state region (IL, KY, OH, NC, and VA)
and requiring these participants to complete T2I2 learning objects and accompanying
written and video artifacts. Submitted artifacts were analyzed using the non-parametric
Wilcoxon-signed-ranks Test, providing evidence that suggested that the field study
teachers demonstrated proficient abilities to contribute to a learning community;
manage, monitor, and adjust learning environments, and increase their self-assessment.
The combined pilot and field test studies provide evidence to support expanding the
development and use of the T2I2 model for science educators for a more interdisciplinary
approach to STEM professional learning experiences.
Ensemble Based Gustafson Kessel Fuzzy Clustering
Authors: Firmansyah Achmad Fauzi Bagus , Pramana Setia 
Published: July 2018

Fuzzy clustering is a clustering method whcih allows an object to belong to two or more cluster by combining hard-clustering and fuzzy membership matrix. Two popular algorithms used in fuzzy clustering are Fuzzy C-Means (FCM) and Gustafson Kessel (GK). The FCM use Euclideans distance for determining cluster membership, while GK use Fuzzy Covariance Matrix that considering covariance between variables. Although GK perform better, it has some drawbacks on handling linearly correlated data, and as FCM the algorithm produce unstable result due to random initialization. These drawbacks can be overcame by using improved covariance estimation and cluster ensemble, respectively. This research presents the implementation of improved covariance estimation and cluster ensemble on GK method and compare it with FCM-Ensemble.
Criteria for selection of probiotics for effective therapy of gut microbiota disorders
Authors: Masharova A. A. , Danilevskaya N. N. 
Published: July 2018

Recently, the substantial progress has been made toward understanding the human microbiota as an ecosystem that functions as a separate organ in a macro-organism. More and more data on the microbiome as the aggregate of microorganism genes that reside on or within the human body appear. Deterioration of the environment, changes in food production technologies, widespread use of antibiotics result in serious human microbiota disorders, most often in the form of gut dysbiosis of varying severity. The investigation into the causes and the correct choice of a probiotic containing the identified microorganisms with the indication of genus, species, strain and their quantitative composition is the criterion for the success of dysbiosis therapy. The purpose of this article is to discuss the criteria for rational probiotic therapy and prevention of gut dysbiosis and associated diseases. It should be considered that the treatment of diseases accompanied by dysbiosis should be comprehensive and include the elimination of the cause of the disease, the correction of nutrition, the elimination of pathogenic agents and their toxins in the gastrointestinal tract, as well as the restoration of the microbiota composition and functional activity. Probiotics play an important role in restoring the composition and functional activity of microbiota. According to the current guidelines of the World Gastroenterological Organization (WGO), a certain quantity of bacteria (KOE of microorganisms) that is necessary to achieve a positive effect is an important criterion for the efficacy of probiotic drugs.
Roundtable discussion: Discussion of the Russian Gastroenterological Association clinical guidelines for the diagnosis and treatment of functional disorders of the biliary tract
Authors: Editorial Article 
Published: July 2018

The roundtable discussion was arranged within the framework of the 106th International Spring Session of the National School of Gastroenterology and Hepatology of the Russian State Medical Academy sponsored by Canonpharma Production. The purpose of the roundtable was to introduce practising physicians to the Russian Gastroenterological Association clinical guidelines for the diagnosis and treatment of functional disorders of the biliary tract. The discussion was held by the Executive Director of the National School of Gastroenterology and Hepatology of the Russian State Medical Academy, the Curriculum Director of the Course “Functional Diagnostics and Pharmacotherapy in Gastroenterology” at the Family Medicine Department of the Faculty of Postgraduate Professional Training of Physicians of I.M. Sechenov Moscow Medical Academy, Elena K. Baranskaya, MD, Professor.
Topical diclofenac for the treatment of the musculoskeletal diseases
Authors: Imametdinova G. R. , Igolkina E. V. 
Published: July 2018

Treatment of diseases of the musculoskeletal system to date remains not only a serious medical, but also socio-economic problem. Chronic diseases of the joints and spine are one of the most common causes of disability in patients. The main clinical manifestations of most diseases of the musculoskeletal system are pain and inflammation, which requires adequate antiinflammatory therapy. The data on various mechanisms of action of non-steroidal anti-inflammatory drug (NSAID) diclofenac (Voltaren), as well as the results of clinical studies and meta-analyses confirming its effectiveness and good tolerability are presented. The data of experimental and clinical studies of the efficacy and safety of local forms of diclofenac-Voltaren Emulgel (diclofenac-diethylamine) –are presented. Provides information about the form of the Voltaren Emulgel 2% for 12 hours. It is shown that a wide range of analgesic and anti-inflammatory effects of diclofenac (Voltaren), and good tolerance can be used as symptomatic therapy in the treatment of diseases of the musculoskeletal system.
Substituted Aminobenzothiazole Derivatives of Tacrine: Synthesis and Study on Learning and Memory Impairment in Scopolamine-Induced Model of Amnesia in Rat
Authors: Ahmadi Abbas , Roghani Mehrdad , Noori Sanaz , Nahri-Niknafs Babak 
Published: July 2018

Background:Currently, there is no conclusive cure for Alzheimer’s disease (AD) and existing treatments mainly offer symptomatic relief. Dysfunction of the cholinergic system plays an important role in the pathogenesis of AD. Tacrine (1, 2, 3, 4-tetrahydroacridin-9-amine, III) was the first approved agent for the palliative therapy of AD but its use is associated with some complications. Development of novel multi target derivatives of Tacrine with lower complications is strongly warranted. In this study, new aminobenzothiazole (1-5, with many useful biological and pharmacological properties) analogues (IV-VIII) were synthesized by changing of amine moiety of III. Then, the effects of these new compounds on learning and memory impairment in scopolamine-induced model of amnesia were studied and the outcomes were compared with control and Tacrine groups in rat.Material and Methods:The rats received Tacrine or its derivatives (IV-VIII) i.p. for two weeks at a dose of 10 mg/kg. For induction of amnesia, scopolamine at a dose of 1 mg/kg was daily administered i.p. started on day-8 till the end of the study. Behavioral experiments including Y-maze, novel object recognition (discrimination) and passive avoidance paradigms were conducted at week 2.Results:Data analysis showed that some Tacrine derivatives, especially VII with 2-amino, 6-nitrobenzothiazole moiety, could markedly and significantly improve alternation score, discrimination ratio and step through latency compared to control and Tacrine groups.Conclusion:These findings indicated that some of these derivatives (especially compounds VI and VII) are capable to mitigate learning and memory deficits in scopolamine-induced model of amnesia in rats and may have potential benefit in management of patients with AD.
Reduced Graphene Oxide Decorated Tio2 for Improving Dye-Sensitized Solar Cells (DSSCs)
Authors: Low Foo Wah , Lai Chin Wei 
Published: July 2018

Background:
In this comprehensive study, the influence of titanium dioxide (TiO2) dopants
decorated on Reduced Graphene Oxide (rGO) via spin coating technique as an efficient photoelectrode
in DSSCs was investigated in detail.

Objective:
This study aims to determine the optimum spinning duration for decorating TiO2 onto
rGO nanosheet photoanode for high DSSCs performance.

Methods:
The rGO nanosheet was prepared using the electrodeposition method. A dropped of 0.2
wt% of TiO2 solution was absorbed using micro-pipette (0.1 μl) and continuously applied on FTOrGO
surface with the rate of 0.1 μl/5s. The spinning duration was varied from 10 to 50 s, and resultant
samples were labelled as Lt, where t= 10, 20, 30, 40 and 50s, respectively.

Results:
The experimental results showed that TiO2 decorated rGO nanosheet photoanode for 30s
spinning duration exhibited a maximum power conversion efficiency of 9.98% than that of pure rGO
nanosheet photoanode (4.74%) under 150 W of xenon irradiation, which is about 2.1 times improvement
in DSSCs performance.

Conclusion:
Ti4+ ion was decorated onto rGO nanosheet leading to the highest interactions with the
O-H functional group or Ti4+ could react with the epoxide or phenolic groups in rGO forming the Ti-
O-C bonds.