bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental sustainability features in large university campuses
Authors: Abu Qdais Hani , Saadeh Osama , Al-Widyan Mohamad , Al-tal Raed , Abu-Dalo Muna 
Published: April 2019

Purpose
The purpose of this study is to describe the efforts undertaken to convert the large university campus of Jordan University of Science and Technology (JUST) into a green, resource-efficient and low-carbon campus by following an action-oriented strategy. Sustainability features of the campus were discussed and benchmarked. Challenges were identified and remedial actions were proposed.

Design/methodology/approach
Taking 2015 as the baseline year, data on energy, water consumption and solid waste generation for the university campus were collected. Energy consumption for cooling, heating and transportation, besides electric power consumption, were reported, and the associated carbon dioxide (CO2) emissions were estimated. By calculating the full time equivalent of students and employees, carbon emission and water consumption per capita were calculated. A comparison with other universities worldwide was conducted.

Findings
Although located in a semiarid region with scarce water resources, JUST has set an example by greening its campus through an action-oriented approach. It was found that the per capita carbon emission for JUST campus was 1.33 ton of CO2 equivalent, which is less than the emissions from campuses of other universities worldwide. As for water, this study revealed that the daily per capita water consumption was about 56 L, which is approximately one-third of that for students in institutions in the USA. Furthermore, the findings of this study indicated that the average solid waste generation rate was 0.37 kg per student per day compared to 0.31 kg per capita per day when considering the university community (students and employees) collectively. These figures were less and thus compare favorably to the corresponding data for other universities in both developing and developed countries.

Originality/value
This research addresses the issue of greening JUST campus, which is one of the largest university campuses in the world. JUST campus is located in a semiarid, water-scarce country, which on its own poses a serious challenge. The originality and value of this study mainly stem from the facts that on the one hand, this is one of the unique and pioneering comprehensive studies of its type and, on the other hand, other universities with similar conditions can benefit from the findings of this research to meet the sustainability objectives on their campus operations.
Assessing differences in customers’ personal disposition to e-commerce
Authors: Ramírez-Correa Patricio Esteban , Grandón Elizabeth E. , Arenas-Gaitán Jorge 
Published: April 2019

Purpose
The purpose of this paper is to determine differences in customers’ personal disposition to online shopping.

Design/methodology/approach
The research model was proposed based on two types of purchases (hedonic vs utilitarian) and on personal traits of individuals against technology throughout the Technology Readiness Index (TRI) 2.0. Generation and gender were considered to evaluate their impact on the type of purchases. Consumers’ data were collected in Chile through 788 face-to-face surveys. The partial least squares approach was used to test the research model.

Findings
The findings show that optimism and discomfort influence online shopping. Moreover, generation and gender moderate the relationship between the dimensions of the TRI and online purchases.

Originality/value
The contributions of this study are threefold. The analysis of personal traits and the type of purchases contribute to the existing literature on consumer behavior and e-commerce, and provide some insights for marketers to identify segmentation strategies by analyzing the gender and generation of individuals. Second, this study contributes to examining the stability and invariances of the TRI 2.0 instrument, which has not been fully revised in less developed countries. Third, this study adds to the existing body of research that argues that demographic variables are not sufficient to understand technology adoption by individuals by including psychological variables.
Open government for all? Co-creating digital public services for older adults through data walks
Authors: Jarke Juliane 
Published: April 2019

Purpose
The purpose of this paper is to review interventions/methods for engaging older adults in meaningful digital public service design by enabling them to engage critically and productively with open data and civic tech.

Design/methodology/approach
The paper evaluates data walks as a method for engaging non-tech-savvy citizens in co-design work. These were evaluated along a framework considering how such interventions allow for sharing control (e.g. over design decisions), sharing expertise and enabling change.

Findings
Within a co-creation project, different types of data walks may be conducted, including ideation walks, data co-creation walks or user test walks. These complement each other with respect to how they facilitate the sharing of control and expertise, and enable change for a variety of older citizens.

Practical implications
Data walks are a method with a low-threshold, potentially enabling a variety of citizens to engage in co-design activities relating to open government and civic tech.

Social implications
Such methods address the digital divide and further social participation of non-tech-savvy citizens. They value the resources and expertise of older adults as co-designers and partners, and counter stereotypical ideas about age and ageing.

Originality/value
This pilot study demonstrates how data walks can be incorporated into larger co-creation projects.
Safety and efficacy of fecal microbiota transplant in 9 critically ill patients with severe and complicated Clostridium difficile infection with impending colectomy
Authors: Alukal Joseph , Dutta Sudhir K , Surapaneni Balarama Krishna , Le Michelle , Tabbaa Obada , Phillips Laila , Mattar Mark C 
Published: April 2019

AbstractObjectiveSignificant data support the efficacy and safety of fecal microbiota transplant (FMT) in recurrent Clostridium difficile infection (CDI). The objective of our study was to determine the success rate of FMT in patients diagnosed with severe and complicated CDI with impending colectomy in the intensive care setting.MethodsThis was a 2‐center study of 9 patients who met the criteria for severe and complicated CDI and had an impending colectomy. All 9 patients had failed conventional antibiotic therapy and were deemed too unstable to undergo a colectomy. Hence, FMT was considered to be the next step in managing their condition.ResultsFollowing FMT there was marked improvement in the patients’ clinical status, with the resolution of diarrhea, reduced requirement for vasopressor, and the reduction in abdominal distention and pain. The primary cure rate of our study after a single round of FMT was 78% (7/9). Of the 9 patients 8 (88.88%) avoided a colectomy during the same hospital admission. the CDI‐related death rate was 12.5% (1/9) and that of non‐CDI was 12.5% (1/9).ConclusionOur success with FMT in fulminant CDI shows that this therapeutic modality is a promising alternative to a colectomy and could be a potential bowel‐saving intervention.
Case study of an inborn error manifested in the elderly: A woman with adult‐onset mitochondrial disease mimicking systemic vasculitis
Authors: Lee Jae Hyun , Kim Min Jung , Park Sung‐Hye , Chae Jong‐Hee , Shin Kichul 
Published: April 2019

AbstractMitochondrial diseases are a group of disorders presenting mainly during infancy due to pathological dysfunction of the mitochondrial respiratory chain. We report a case of mitochondrial disease in an elderly woman complaining of generalized myalgia. A 69‐year‐old woman was admitted due to fatigue, general weakness, and a drowsy mental status. A brain magnetic resonance imaging (MRI) demonstrated multifocal lesions of increased T2 signal intensity, and laboratory findings were consistent with Fanconi syndrome. During her hospital course, she developed seizures, stress‐induced cardiomyopathy, and respiratory failure. A muscle biopsy demonstrated ragged‐red fibers in the muscle tissues seen in mitochondrial myopathy. We confirmed an 8 kb deletion in her mitochondrial DNA. Following treatment with l‐carnitine, coenzyme Q10, and supportive measures, brain lesions on MRI scans disappeared, and the general symptoms gradually improved.
The price effects of cross‐market mergers: theory and evidence from the hospital industry
Authors: Dafny Leemore , Ho Kate , Lee Robin S. 
Published: April 2019

AbstractWe consider the effect of mergers between firms whose products are not viewed as direct substitutes for the same good or service, but are bundled by a common intermediary. Focusing on hospital mergers across distinct geographic markets, we show that such combinations can reduce competition among merging hospitals for inclusion in insurers' networks, leading to higher prices (or lower‐quality care). Using data on hospital mergers from 1996–2012, we find support that this mechanism operates within state boundaries: cross‐market, within‐state hospital mergers yield price increases of 7%–9 % for acquiring hospitals, whereas out‐of‐state acquisitions do not yield significant increases.
Microbial eukaryotes in the suboxic chemosynthetic ecosystem of Movile Cave, Romania
Authors: Reboul Guillaume , Moreira David , Bertolino Paola , Hillebrand‐Voiculescu Alexandra Maria , López‐García Purificación 
Published: April 2019

SummaryMovile Cave is a small system of partially inundated galleries in limestone settings close to the Black Sea in Southeast Romania. Isolated from the surface for 6 million years, its sulfidic, methane and ammonia‐rich waters harbour unique chemosynthetic prokaryotic communities that include sulphur and ammonium‐metabolizing chemolithotrophs, methanogens, methanotrophs and methylotrophs. The cave also harbours cave‐dwelling invertebrates and fungi, but the diversity of other microbial eukaryotes remained completely unknown. Here, we apply an 18S rRNA gene‐based metabarcoding approach to study the composition of protist communities in floating microbial mats and plankton from a well‐preserved oxygen‐depleted cave chamber. Our results reveal a wide protist diversity with, as dominant groups, ciliates (Alveolata), Stramenopiles, especially bicosoecids, and jakobids (Excavata). Ciliate sequences dominated both, microbial mats and plankton, followed by either Stramenopiles or excavates. Stramenopiles were more prominent in microbial mats, whereas jakobids dominated the plankton fraction of the oxygen‐depleted water column. Mats cultured in the laboratory were enriched in Cercozoa. Consistent with local low oxygen levels, Movile Cave protists are most likely anaerobic or microaerophilic. Several newly detected OTU clades were very divergent from cultured species or environmental sequences in databases and represent phylogenetic novelty, notably within jakobids. Movile Cave protists likely cover a variety of ecological roles in this ecosystem including predation, parasitism, saprotrophy and possibly diverse prokaryote‐protist syntrophies.
The spleen morphophysiology of fruit bats
Authors: Hanadhita Desrayni , Rahma Anisa , Prawira Andhika Yudha , Mayasari Ni Luh Putu Ika , Satyaningtijas Aryani Sismin , Hondo Eiichi , Agungpriyono Srihadi 
Published: April 2019

AbstractSpleen is one of the important lymphoid organs with wide variations of morphological and physiological functions according to species. Morphology and function of the spleen in bats, which are hosts to several viral strains without exhibiting clinical symptoms, remain to be fully elucidated. This study aims to examine the spleen morphology of fruit bats associated with their physiological functions. Spleen histological observations were performed in three fruit bats species: Cynopterus titthaecheilus (n = 9), Rousettus leschenaultii (n = 3) and Pteropus vampyrus (n = 3). The spleens of these fruit bats were surrounded by a thin capsule. Red pulp consisted of splenic cord and wide vascular space filled with blood. Ellipsoids in all three studied species were found numerously and adjacent to one another forming macrophages aggregates. White pulp consisted of periarteriolar lymphoid sheaths (PALS), lymphoid follicles and marginal zone. The lymphoid follicle contained a germinal centre and a tingible body macrophage that might reflect an active immune system. The marginal zone was prominent and well developed. This study reports some differences in spleen structure of fruit bats compared to other bat species previously reported and discusses possible physiological implications of the spleen based on its morphology.
Quality improvement in surgery: introduction of the American College of Surgeons National Surgical Quality Improvement Program into New South Wales
Authors: Richardson Arthur J. , Cox Michael R. , Shakeshaft Anthony J. , Hodge Bruce , Morgan Gary , Pang Tony , Zeng Mingjuan , Scanlon Kate , Austin Robyn , Dawadi Ashma , Burgess Crystal , Rawstron Ellen , Dalton Sarah , Leveque Jean‐Frederic 
Published: April 2019

BackgroundQuality improvement in surgery requires accurate, reliable, risk‐adjusted and comparative data. The American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) takes reliable clinical data and provides risk‐adjusted comparisons with more than 800 hospitals. This paper describes the early outcomes of introducing this programme into New South Wales (NSW).MethodsFour NSW hospitals formed a collaborative. Surgical clinical reviewers were trained and data collected. Risk‐adjusted reports were returned to individual hospitals and the NSW Collaborative.ResultsThe results identified that the NSW Collaborative were outliers for the following causes of morbidity: urinary tract infections, surgical site infections, pneumonia and 30‐day readmissions.ConclusionWe have shown that ACS‐NSQIP can be adapted to Australia and there is a plan to widen the programme in NSW.
Predictive energy equations are inaccurate for determining energy expenditure in adult burn injury: a retrospective observational study
Authors: Leung James , Ridley Emma J. , Cleland Heather , Ihle Joshua F. , Paul Eldho , King Susannah J. 
Published: April 2019

BackgroundSevere burn injuries are associated with hypermetabolism. This study aimed to compare the measured energy expenditure (mEE) with predicted energy requirements (pERs), and to correlate energy expenditure (EE) with clinical parameters in adults with severe burn injury.MethodsData were retrospectively analysed on 29 burn patients (median (interquartile range) age: 46 (28–61) years, % total body surface area burn: 37% (18–46%)) admitted to an intensive care unit. Indirect calorimetry was performed on 1–4 occasions per patient to measure EE. mEE was compared with pER calculated using four prediction equations. Bland–Altman and correlation analyses were performed.ResultsMean ± SD mEE was 9752 ± 2089 kJ/day (143 ± 32% of predicted basal metabolic rate). Bland–Altman analysis demonstrated clinically important overestimation for three of the four prediction equations and wide 95% limits of agreement for all equations. Overestimation of EE was more marked early post‐burn. mEE correlated with day post‐burn (r = 0.42, P = 0.004) and number of operations prior to first EE measurement (r = 0.34, P = 0.016), but not with % total body surface area (r = 0.02, P = 0.9).ConclusionsPatients with severe burn injury exhibit hypermetabolism. The observed poor agreement between pER and mEE at an individual level indicates the value of indirect calorimetry in determining EE in burn injury.
Conservative treatment of rectosigmoid endometriosis: A prospective study
Authors: Egekvist Anne G. , Marinovskij Edvard , Forman Axel , Kesmodel Ulrik S. , Graumann Ole , Seyer‐Hansen Mikkel 
Published: April 2019

AbstractIntroductionDeep infiltrating endometriosis is a common cause of pelvic pain. However, some patients have limited problems that may be controlled by medical treatment, so avoiding the potentially severe complications of major surgery. This approach requires detailed knowledge on quality of life and clinical symptoms over time. The aim of the study was to monitor these parameters in patients with rectosigmoid endometriosis treated with oral contraceptives, oral gestagens, and/or the levonorgestrel‐releasing intrauterine device. Moreover, nodule size measurements performed with transvaginal sonography were correlated to severity of symptoms.Material and methodsConservatively treated patients on oral contraceptives, oral gestagens, or the levonorgestrel‐releasing intrauterine device underwent transvaginal sonography and answered a self‐administered questionnaire regarding clinical symptoms and quality of life (Short Form 36 and Endometriosis Health Profile 30) at baseline, and 6 and 12 months later.ResultsEighty women completed the follow up. Scores of quality of life were comparable to normative data for Danish women of similar age and did not change with time. No association between change in size of the rectosigmoid nodule and change in symptoms was seen.ConclusionsThis study supports that simple treatment with oral contraceptives, oral gestagens, or the levonorgestrel‐releasing intrauterine device represents a viable therapeutic approach to rectosigmoid Deep infiltrating endometriosis, provided that proper selection of patients in need of surgery exists.
Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2
Authors: Pauleikhoff Daniel , Bonelli Roberto , Dubis Adam M , Gunnemann Frederic , Rothaus Kai , Charbel Issa Peter , Heeren Tjebo FC , Peto Tunde , Clemons Traci E , Chew Emily Y , Bird Alan C , Sallo Ferenc B ,   The MacTel Study Group
Published: April 2019

AbstractPurposeTo investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity.MethodsParticipants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral‐Domain Optical Coherence Tomograph (SD‐OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models.ResultsA total of 134 eyes of 70 patients were included (85 eyes with follow‐up, mean 4.7 years, range: 1.4–8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm2 (p = 0.005). The progression rate was non‐linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity.ConclusionEllipsoid zone (EZ) loss in MacTel has a non‐linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best‐corrected visual acuity by EZ location, which may help routine clinical practice.
Look who’s talking: Exploring instructors’ contributions to Massive Open Online Courses
Authors: Goshtasbpour Fereshte , Swinnerton Bronwen , Morris Neil Peter 
Published: April 2019

AbstractPrevious research on xMOOC pedagogy has established that learner interactions in discussion forums play a fundamental role in learning. However, little is known about the extent to which MOOC instructors engage with learner conversations and the impact this has on learner engagement. Adopting a novel design, this study went beyond self‐reported methods, and combined transcript analysis and in‐depth interviews to examine the dynamics of learner‐instructor interactions and to revisit the use of the Community of Inquiry framework (CoI) in MOOC context. The findings revealed that the majority of instructors’ contributions to learner conversations are social, followed by teaching and cognitive contributions. While all contribution types decreased over the duration of the MOOC, the relative importance of each type did not necessarily change. Furthermore, the analysis showed that learners engaged with 42% of instructor contributions by responding to or liking them or both. Considering the application of the CoI to massive and open online learning contexts, this study demonstrates that while the framework can unfold educational transactions in MOOCs, reoperationalisation and reconceptualisation of some indicators along with the introduction of new indicators are essential. The implications of this for theory and practice are discussed.
Prognostic significance of mutation profile at diagnosis and mutation persistence during disease remission in adult acute myeloid leukaemia patients
Authors: Folta Adam , Culen Martin , Jeziskova Ivana , Herudkova Zdenka , Tom Nikola , Hlubinkova Tereza , Janeckova Veronika , Durinikova Anna , Vydra Jan , Semerad Lukas , Dvorakova Dana , Remesova Hana , Cerovska Ela , Cetkovsky Petr , Jindra Pavel , Szotkowski Tomas , Zak Pavel , Mayer Jiri , Racil Zdenek 
Published: April 2019

SummaryIn this multi‐centre study, we analysed the prognostic impact of mutations in 19 genes associated with myeloid malignancies in 258 newly diagnosed acute myeloid leukaemia patients (aged 19–70 years) undergoing intensive therapy. We identified five patient groups with different prognostic risks and different benefits from allogeneic hematopoietic stem cell transplantation (alloHSCT) within the intermediate cytogenetic risk group patients (n = 184). The most adverse prognosis was observed in patients with DNMT3A and FLT3‐ITD co‐mutation, whose survival could be significantly improved with alloHSCT. In contrast, the most favourable prognosis without any further benefit from alloHSCT was identified in patients with mutations in NPM1 or CEBPA, after exclusion of the unfavourable prognostic groups defined by mutations in DNMT3A, RUNX1 or genes from chromatin/spliceosome group. An additional analysis of 113 diagnosis‐remission paired samples revealed that persistence of non‐DNMT3A mutations (above 2% VAF) represented a further negative prognostic factor. The proposed model offers a possible molecular stratification and treatment guidance for intermediate cytogenetic risk group patients.