bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cornu Ammonis Changes Are at the Core of Hippocampal Pathology in Depression
Authors: Roddy Darren , O’Keane Veronica 
Published: May 2019

Commentary on: Roddy DW, Farrell C, Doolin K, Roman E, Tozzi L, Frodl T, O'Keane V, O'Hanlon E. The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation in Depression. Biol Psychiatry. 2019 Mar 15;85(6):487-497. doi: 10.1016/j.biopsych.2018.08.021. Epub 2018 Sep 6. PubMed PMID: 30528746. The hippocampus is a key cognitive hub implicated in major depressive disorder. However, major depressive disorder neuroimaging studies have used inconsistent anatomical hippocampal definitions to estimate hippocampal volumes, leading to some heterogeneity in findings. In a recent paper, we used a novel reassembly of automated hippocampal substructures (composites) to build alternative anatomical hippocampal definitions and used these to investigate differences in a well-defined cohort of major depressive disorder patients and healthy controls. We found that the most significant differences between major depressive disorder and healthy controls were localized to the core cornu ammonis (CA) regions of the hippocampus. The CA2–4 regions were smaller in first episode major depressive disorder, whereas more widespread differences were found in recurrent/chronic major depressive disorder, suggestive of a potential disease process in major depressive disorder. In this commentary, we also show how new hippocampal composites to investigate sections of the hippocampal circuitry demonstrate that differences in major depressive disorder occur across the input, middle and output circuit nodes of the hippocampal core. Hippocampal pathology localized across the core hippocampal CA circuity may account for the diverse and wide-ranging symptoms often experienced in depression.
Moment-to-moment interaction between affectivity and coping behaviours in bipolar disorder and the role of cognitive appraisals
Authors: Leung Michelle Hoi-ting , So Suzanne Ho-wai , Kwok Nate Tsz-Kit , Ng Iris Hoi-ching , Chan Pui-shuen , Lo Chloe Chor-wing , Na Shirley , Mak Arthur Dun-ping , Lee Sing 
Published: May 2019

Background
Individuals with bipolar disorder respond to affective symptoms with a range of coping behaviours, which may further maintain the symptoms.

Aims
To examine moment-to-moment dynamics between affective states and coping behaviours, and to evaluate the role of cognitive appraisals of internal states as moderators.

Method
Forty-six individuals with bipolar disorder completed a clinical interview and an experience sampling assessment over 6 days. Time-lagged analyses were conducted by multilevel regression modelling.

Results
A total of 1807 momentary entries were analysed. Negative affect predicted an increase in rumination at the subsequent time point (β = 0.21, s.e. = 0.08, P = 0.009, 95% CI 0.05–0.36), and vice versa (β = 0.03, s.e. = 0.01, P = 0.009, 95% CI 0.01–0.05). Positive affect predicted an increase in adaptive coping (β = 0.26, s.e. = 0.11, P = 0.018, 95% CI 0.04–0.47), and vice versa (β = 0.02, s.e. = 0.01, P = 0.019, 95% CI 0.00–0.03). Positive affect also predicted a decrease in rumination (β = −0.15, s.e. = 0.06, P = 0.014, 95% CI −0.26 to −0.03), and vice versa (β = −0.03, s.e. = 0.01, P = 0.016, 95% CI −0.06 to −0.01). Extreme cognitive appraisals predicted stronger associations between affective states and coping behaviours.

Conclusions
Feedback loops between affective states and coping behaviours were revealed in the daily life of individuals with bipolar disorder, which were moderated by extreme cognitive appraisals.

Declaration of interest
None.
Improving performance of inverse Compton sources through laser chirping
Authors: Terzić B. , Brown A. , Drebot I. , Hagerman T. , Johnson E. , Krafft G. A. , Maroli C. , Petrillo V. , Ruijter M. 
Published: May 2019

Abstract
We present a new method for computation of radiation spectra in the non-linear regime of operation of inverse Compton sources characterized by high laser intensities. The resulting simulations agree well with the experiments. Increasing the laser intensity changes the longitudinal velocity of the electrons during their collision, leading to considerable non-linear broadening in the scattered radiation spectra. The effects of such ponderomotive broadening are so deleterious that most inverse Compton sources either remain at low laser intensities or pay a steep price to operate at a small fraction of the physically possible peak spectral output. This ponderomotive broadening can be reduced by a suitable frequency modulation (also referred to as “chirping”, which is not necessarily linear) of the incident laser pulse, thereby drastically increasing the peak spectral density. This frequency modulation, included in the new code as an optional functionality, is used in simulations to motivate the experimental implementation of this transformative technique.
Stylohyoid Ligament Calcification: A Greater-Than-Expected Cause of Otalgia in Turner Syndrome
Authors: Monteagudo Patricia Teofilo , Rossinol Vinicius Loures , do Nascimento Verreschi Ieda Therezinha , Dias-da-Silva Magnus Regios 
Published: May 2019

AbstractContextOtitis is common in patients with Turner syndrome (TS) and may be misdiagnosed in the presence of other causes of otalgia.ObjectiveWe hypothesized that stylohyoid ligament calcification (SLC), named Eagle syndrome (ES), is a common cause of otalgia in TS.DesignCohort of 1-year data collection.SettingWe analyzed all consecutive women with Turner syndrome (TW).PatientsNinety-six TW and 55 age-paired normal control women (CW).InterventionParticipants were asked about current or past otalgia and had bilateral tonsillar palatine palpated by the same physician.Main Outcome MeasuresWhen otalgia or cervicalgia plus painful palatine tonsil palpation was positive, participants underwent facial X-ray or three-dimensional cranial CT. If SLC was >25 mm, ES was confirmed.ResultsThirty-four TW (35%) had clinical signs and 27/34 (79%) had radiologically confirmed ES. Of the TW with confirmed ES (27/96; 28%), 14 (51.9%) were inadvertently treated for recurrent otitis as a presumed cause of otalgia. Eleven of the TW with ES (26.1%) were below age 21. There was no association with karyotype, age, body mass index, or growth hormone use. Ten CW (18.2%) complained of symptoms of ES, but only 4 (7.3%) were radiologically confirmed (CW vs TW, P < 0.01), and none were <21 years old. ES occurred more at younger ages in TW (P < 0.002).ConclusionES is more prevalent in TW than in controls and occurs at younger ages. ES must be assessed as a common comorbidity of TS at any age, especially during childhood, as a differential diagnosis of otalgia.
What’s in a Name? Vincent Ogé, Toussaint Louverture, and George Boyer Vashon’s Revision of the Haitian Revolution
Authors: Windon Nathaniel A. 
Published: May 2019

AbstractThis essay argues that George Boyer Vashon’s epic poem, “Vincent Ogé” (1854), reframes the Haitian Revolution by aligning two moments of imminent revolution—Saint-Domingue in the late eighteenth century and the United States in the mid-nineteenth century—to suggest the free black people of the United States might activate the volcanic latency of racial discontent in their country just as Ogé had in his. At the same time, Vashon’s revision of John Greenleaf Whittier’s poem “Toussaint L’Ouverture” (1833) offsets the way in which Louverture’s name had become overburdened within the transatlantic antislavery discourse of the mid-nineteenth century. In doing so, “Vincent Ogé” shifts attention from the singular heroism of Louverture to the plurality of contributors that shaped the long history of the Haitian Revolution.
Revising Ho Chi Minh: Diasporic Historical Fiction in The Book of Salt and The Zenith
Authors: Tam Hao Jun 
Published: May 2019

Abstract
Through a reading of Vietnamese American author Monique Truong’s The Book of Salt (2003) and Parisian writer-in-exile Duong Thu Huong’s The Zenith (2012), this essay examines the ways in which the two diasporic Vietnamese novels revise modern Vietnam’s founding father Ho Chi Minh and thereby challenge the Communist Party’s official historiography. Resisting both the lingering civil war’s Manichaeanism and the militant anti-Communism of the diaspora, the texts present Ho as a figure of hope through which to imagine national reunification and an alternative future for Vietnam.
MetaDEGalaxy: Galaxy workflow for differential abundance analysis of 16s metagenomic data
Authors: Thang Mike W.C. , Chua Xin-Yi , Price Gareth , Gorse Dominique , Field Matt A. 
Published: May 2019

Metagenomic sequencing is an increasingly common tool in environmental and biomedical sciences yet analysis workflows remain immature relative to other field such as DNASeq and RNASeq analysis pipelines. While software for detailing the composition of microbial communities using 16S rRNA marker genes is constantly improving, increasingly researchers are interested in identifying changes exhibited within microbial communities under differing environmental conditions. In order to gain maximum value from metagenomic sequence data we must improve the existing analysis environment by providing accessible and scalable computational workflows able to generate reproducible results. Here we describe a complete end-to-end open-source metagenomics workflow running within Galaxy for 16S differential abundance analysis. The workflow accepts 454 or Illumina sequence data (either overlapping or non-overlapping paired end reads) and outputs lists of the operational taxonomic unit (OTUs) exhibiting the greatest change under differing conditions. A range of analysis steps and graphing options are available giving users a high-level of control over their data and analyses. Additionally, users are able to input complex sample-specific metadata information which can be incorporated into differential analysis and used for grouping / colouring within graphs. Detailed tutorials containing sample data and existing workflows are available for three different input types: overlapping and non-overlapping read pairs as well as for pre-generated Biological Observation Matrix (BIOM) files. Using the Galaxy platform we developed MetaDEGalaxy, a complete metagenomics differential abundance analysis workflow. MetaDEGalaxy is designed for bench scientists working with 16S data who are interested in comparative metagenomics. MetaDEGalaxy builds on momentum within the wider Galaxy metagenomics community with the hope that more tools will be added as existing methods mature.
A phase IIb study to determine the safety and efficacy of candidate INfluenza Vaccine MVA-NP+M1 in combination with licensed InaCTivated inflUenza vaccine in adultS aged 65 years and above (INVICTUS): a study protocol
Authors: Swayze Hannah , Allen Julie , Folegatti Pedro , Yu Ly-Mee , Gilbert Sarah , Hill Adrian , Ellis Chris , Butler Christopher C. 
Published: May 2019

Seasonal influenza has a significant annual global impact. Current influenza vaccines work by inducing strain-specific antibodies against the highly polymorphic surface proteins of the influenza virus and need to be redesigned every year, increasing their cost and limiting availability. There is a demand for a more efficacious vaccine, particularly in older adults in which the current vaccines show poor efficacy. The aim is to investigate a novel vaccine, MVA-NP+M1, which targets T cell responses to the nucleoprotein and matrix 1 core proteins of the influenza virus A, which are highly conserved, and therefore may provide long protection against a broad range of influenza strains. INVICTUS is a phase IIb study to determine the safety and efficacy of candidate INfluenza Vaccine MVA-NP+M1 in combination with licensed InaCTivated inflUenza vaccine in adultS aged 65 years and above is a randomised, participant-blinded, placebo-controlled, multi-centre phase IIb efficacy study planned for 2030 volunteers aged 65 and over, in primary care. The primary objective is to assess the efficacy of MVA-NP+M1 co-administered with licensed inactivated quadrivalent influenza vaccine in adults ≥65 years. Participants complete daily diaries to record solicited and unsolicited events in the first four weeks post vaccination, and influenza-like illness (ILI) symptoms and severity throughout the influenza season. We hypothesise an improvement in the primary outcome, a reduction in the average number of days spent with moderate or severe influenza-like illness during periods of influenza circulation, in the group administered with MVA-NP+M1, compared to those in the control group. Registration: ClinicalTrials.gov identifier NCT03300362. Protocol version: INVICTUS Protocol v3.0, 08 June06 2018.
Sustainable Inventory with Robust Periodic-Affine Policies and Application to Medical Supply Chains
Authors: Bandi Chaithanya , Han Eojin , Nohadani Omid 
Published: May 2019

We introduce a new class of adaptive policies called periodic-affine policies, which allows a decision maker to optimally manage and control large-scale newsvendor networks in the presence of uncertain demand without distributional assumptions. These policies are data-driven and model many features of the demand such as correlation and remain robust to parameter misspecification. We present a model that can be generalized to multiproduct settings and extended to multiperiod problems. This is accomplished by modeling the uncertain demand via sets. In this way, it offers a natural framework to study competing policies such as base-stock, affine, and approximative approaches with respect to their profit, sensitivity to parameters and assumptions, and computational scalability. We show that the periodic-affine policies are sustainable—that is, time consistent—because they warrant optimality both within subperiods and over the entire planning horizon. This approach is tractable and free of distributional assumptions, and, hence, suited for real-world applications. We provide efficient algorithms to obtain the optimal periodic-affine policies and demonstrate their advantages on the sales data from one of India’s largest pharmacy retailers. This paper was accepted by Yinyu Ye, optimization.
Bad Testimony: Making and Breaking the Rules of Witnessing
Authors: Pollin-Galay Hannah 
Published: May 2019

What is testimony? While most theorists have defined testimony based on deep truth structures, here the question is approached inductively, asking what kinds of speech the participants in each setting consider testimonial, and thus worth recording, and which they do not. In each ecology, participants rely on a different testimonial genre, a cluster of qualities and imaginative ideals, which helps them produce a recording together: 1) testimony in the English-language American context should be personal, in the way that the witness’s voice sounds and allegorical in its possible rhetorical outcome, 2) a communal witness voice, an “I” that incorporates political and national institutions, is more prominent among Hebrew-Israeli witnesses, and monumentality, the greatness or dignity of the narrator, is the ideal outcome of the process, 3) witnesses in the Yiddish-Lithuanian ecology tend to speak from an informal collective perspective, and point toward forensic accusation as the most ethical outcome of testifying. Since the power of these frameworks remains invisible when they are consensually applied, their presence becomes clearest, in fact, when participants run into conflict—in what we might call moments of “bad testimony.” The chapter also offers a brief genealogy of testimony taking in each of the three settings.
Conclusion
Authors: Pollin-Galay Hannah 
Published: May 2019

The Conclusion coalesces the chapter themes—interviewing genre, family, enemies, language, and place—in relation to one another, and to the question of the Holocaust as catastrophe, as transvaluation. It ends by reflecting on the outcomes of the Era of the Witness as a translation project. While testimony takers may have sought to unite Jewish memories by traversing the globe with cameras and questionnaires in the 1990s, their efforts revealed valuable tensions between different loci of Jewish memory. We should therefore challenge attempts to universalize catastrophe narratives but also avoid facile accusations against the North American institutions that brought their testimonial visions abroad. When we examine Holocaust testimony recordings of the past 40 years, we discover the “Era of the Witness” to be much more of an encounter between different memory paradigms, rather than a hegemonic overthrow of one in place of another. This encounter has, even if by accident, created rich material for rethinking what catastrophe is made of, and how it looks and sounds in personal form.
Direct Support Professionals' Perspectives on Ambulatory Health Care Processes and Quality
Authors: Tyler Carl V. , Wells Michael D. ,   Developmental Disabilities–Practice-Based Research Network
Published: May 2019

Abstract
Direct support professionals (DSPs) frequently accompany persons with intellectual and other developmental disabilities (IDD) to their health care appointments and could offer valuable insights into potential target areas for health-care improvement. DSPs completed surveys assessing healthcare processes and quality immediately following 118 ambulatory health care encounters involving their patients with IDD. Although DSPs generally judged the quality of health care as good (44%) or excellent (52%), they also observed that physicians directed questions to the DSP that the patient could have answered in 22% of encounters, and noted that physicians failed to ask critical psychosocial information in 24% of encounters. Competency-based training of DSPs around health-care advocacy could significantly improve the quality of health care provided to persons with IDD.
Exploring the Valley of Savings: Minimizing Part D Costs and Optimizing Drug Therapy Outcomes in Medicare Beneficiaries With Developmental Disability
Authors: Rogan Edward L. , Ranson Carly A. , Mori Traci K. , Park Salley K. , Lam Howard M. , Legaspi Jamie F. , Tran Lan Kim , Cameros Christine Julie M. , Blackburn Amy Natsuki , Lee Sandra T. , Valle-Oseguera Cynthia S. , Pham Christopher N. , Woelfel Joseph A. , Patel Rajul A. 
Published: May 2019

Abstract
Nonelderly disabled Medicare beneficiaries have a higher prevalence of chronic conditions, higher utilization of prescription medications, and increased demand for clinical services when compared to beneficiaries 65 years of age and older who are not disabled. Out-of-pocket costs and medication-related problems are major barriers to medication compliance and achievement of therapeutic goals. A school of pharmacy partnered with a nonprofit organization that provides care to individuals with developmental disabilities. The present study highlights outcomes resulting from (a) providing Medicare Part D plan optimization services to lower prescription drug costs and (b) Medication Therapy Management services to evaluate safe and effective medication use in this beneficiary population. Provided interventions were shown to reduce overall medication costs and identify significant medication-related problems.
ADAPTIVE SPACE OF JAVANESE TRADITIONAL HOUSE IN BRAYUT TOURISM VILLAGE YOGYAKARTA
Authors: Vitasurya Vincentia Reni , Hardiman Gagoek , Sari Suzanna Ratih 
Published: May 2019

Traditional Javanese architecture, especially in rural areas, has undergone a major transformation. Transformation is owner’s response to various conditions, such as the increasing number of family members, the improvement of social status and economic conditions, the needs of modernization and the consequences of being involved in government’s programs. This paper aim is to examine how the owners of traditional houses respond to nowadays changes reflected through their houses designs. Brayut tourism village is a traditional settlement located at Yogyakarta’s downtown area which is well known for its unique and well-preserved traditional Javanese houses. The transformation of traditional houses in Brayut is a combination of the need for change and persistence. On the one side, strong local traditions play a role in maintaining the elements of traditional houses and on the other side, dynamic modern needs play a role as a trigger for change. Adaptive space in the traditional house is a solution to this problem. The method used in this research is a case study on some Javanese traditional houses. An in-depth interview with the owners and mapping are also used to examine the chronology of traditional houses transformation. Transformation aspects are defined on the affected physical architecture elements. The result of this study is the transformation occurs on function and meaning of space as an adaptive response from the owners. While the shape of space and buildings, generally preserved as an effort to maintain the bond of traditions and trust.
A Picone identity for variable exponent operators and applications
Authors: Arora Rakesh , Giacomoni Jacques , Warnault Guillaume 
Published: May 2019

Abstract
In this work, we establish a new Picone identity for anisotropic quasilinear operators, such as the p(x)-Laplacian defined as div(|∇ u|
p(x)−2 ∇ u). Our extension provides a new version of the Diaz-Saa inequality and new uniqueness results to some quasilinear elliptic equations with variable exponents. This new Picone identity can be also used to prove some accretivity property to a class of fast diffusion equations involving variable exponents. Using this, we prove for this class of parabolic equations a new weak comparison principle.
Overexpression of RASAL1 indicates poor prognosis and promotes invasion of ovarian cancer
Authors: Chang Rui-Xia , Cui Ai-Ling , Dong Lu , Guan Su-Ping , Jiang Ling-Yan , Miao Cong-Xiu 
Published: May 2019

AbstractRAS protein activator like-1 (RASAL1) exists in numerous human tissues and has been commonly demonstrated to act as a tumor suppressor in several cancers. This study aimed to identify the functional characteristics of RASAL1 in ovarian adenocarcinoma and a potential mechanism of action. We analyzed RASAL1 gene expression in ovarian adenocarcinoma samples and normal samples gained from the GEO and Oncomine databases respectively. Then the relationship between RASAL1 expression and overall survival (OS) was assessed using the Kaplan-Meier method. Furthermore, the biological effect of RASAL1 in ovarian adenocarcinoma cell lines was assessed by Quantitative real time-PCR (qRT-PCR), Cell Counting Kit-8 (CCK-8), western blot, wound healing and transwell assay. The statistical analysis showed patients with higher RASAL1 expression correlated with worse OS. The in vitro assays suggested knockdown of RASAL1 could inhibit cell proliferation, cell invasion and migration of ovarian adenocarcinoma. Moreover, the key proteins in the mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK/ERK) signaling pathway were also decreased in ovarian adenocarcinoma cells with RASAL1 silencing. These findings provide promising evidence that RASAL1 may be not only a powerful biomarker but also an effective therapeutic target of ovarian adenocarcinoma.