bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile e‐diary application facilitates the monitoring of patient‐reported outcomes and a high treatment adherence for clinical trials in dermatology
Authors: Rijsbergen M. , Niemeyer‐van der Kolk T. , Rijneveld R. , Pinckaers J.H.F.M. , Meshcheriakov I. , Bouwes Bavinck J.N. , van Doorn M.B.A. , Hogendoorn G. , Feiss G. , Cohen A.F. , Burggraaf J. , van Poelgeest M.I.E. , Rissmann R. 
Published: August 2019

AbstractBackgroundAssessment of treatment effects in clinical trials requires valid information on treatment adherence, adverse events and symptoms. Paper‐based diaries are often inconvenient and have limited reliability, particularly for outpatient trials.ObjectivesTo investigate the utility of an electronic diary (e‐diary) application for patients with skin diseases in outpatient clinical trials.MethodsAn e‐diary application was developed and technically validated. Treatment adherence was defined as topical administration by the patient, and patient‐reported outcomes, i.e. pain and itch, were evaluated by the e‐diary in six clinical trials on newly tested topical drugs. Additionally, the proportion of patients capturing the applied topical drug by camera and filling in the pain and itch scores was defined as e‐diary adherence, and patients’ perception of usefulness and acceptability of the e‐diary were evaluated.ResultsTreatment adherence rates of the included 256 patients were high (median 98%, range 97–99%). E‐diary adherence was also high with a median of 93% (range 87–97%) for capturing the applied drug by camera, and 89% (range 87–96%) and 94% (range 87–96%) for entering respectively the itch and pain score. Daily symptom scores provided good insights into the disease burden, and patients rated the e‐diary as good to excellent with respect to user acceptability.ConclusionsThe results suggest that the e‐diary is an excellent way to ensure proper treatment administration, indicated by both the high user acceptability scores and high treatment adherence. Moreover, the e‐diary may also be valuable for frequent and reliable monitoring of patient‐reported outcomes in daily clinical practice.
Analysis of the gut microbiota in alopecia areata: identification of bacterial biomarkers
Authors: Moreno‐Arrones O.M. , Serrano‐Villar S. , Perez‐Brocal V. , Saceda‐Corralo D. , Morales‐Raya C. , Rodrigues‐Barata R. , Moya A. , Jaen‐Olasolo P. , Vano‐Galvan S. 
Published: August 2019

AbstractBackgroundAlopecia areata is a T‐cell‐mediated autoimmune disease with an unknown etiopathogenesis. Gut microbiota has been revealed as a key modulator of systemic immunity.ObjectiveTo determine whether patients affected by alopecia universalis present differences in gut bacteria composition compared with healthy controls and investigate possible bacterial biomarkers of the disease.MethodsWe conducted a cross‐sectional study that involved 15 patients affected by alopecia universalis and 15 controls. Gut microbiome of the study subjects was analysed by sequencing the 16SrRNA of stool samples. We searched for bacterial biomarkers of alopecia universalis using the linear discriminant analysis effect size (LEFse) tool.ResultsIn total, 30 study subjects (46.6% female; mean [SD] age, 40.1 [9.8] years) were enrolled. Neither alpha (Shannon diversity index 5.31 ± 0.43 vs. 5.03 ± 0.43, P 0.1) or beta diversity (ADONIS P value: 0.35) of gut microbiota showed statistically significant differences between cases and controls. In patients affected with alopecia, we found an enriched presence (LDA SCORE > 2) of Holdemania filiformis, Erysipelotrichacea, Lachnospiraceae, Parabacteroides johnsonii, Clostridiales vadin BB60 group, Bacteroides eggerthii and Parabacteroides distasonis. A predictive model based on the number of bacterial counts of Parabacteroides distasonis and Clostridiales vadin BB60 group correctly predicted disease status in 80% of patients (AUC 0.804 (0.633–0.976), P 0.004).ConclusionAlopecia universalis does not seem to affect broadly gut microbiota structure. Bacterial biomarkers found associated with the disease (Holdemania filiformis, Erysipelotrichacea, Lachnospiraceae, Parabacteroides johnsonii, Eggerthellaceae, Clostridiales vadin BB60 group, Bacteroides eggerthii and Parabacteroides distasonis) should be further studied as they could be involved in its pathophysiology or be used as diagnostic tools.
Construction of a design space for goat milk powder production using moisture sorption isotherms
Authors: Nascimento Amanda , Cavalcanti‐Mata Mario E. R. M. , Martins Duarte Maria E. , Pasquali Matheus , Lisboa Hugo M. 
Published: August 2019

AbstractIndustrialization of goat milk is critical to meet increasing demand. For process optimization and proper preservation of the product, information given by sorption isotherms can be fundamental. Therefore, the objective of this work was to determine the sorption isotherms of the goat milk powder and use that information to build a design space for the spray drying process. By fitting different mathematical models (GAB, Cavalcanti Mata, Thompson, and Oswin) to the experimental data, thermodynamic data was also determined as a function of equilibrium water content. The results allowed the construction of a phase diagram based on glass transition temperatures, and moisture content of 2.40% at the monolayer which provided a reference for the range of stability of water activity and a target for the final moisture content. By determination of net isosteric heat, it is clear that the values of energy for drying goat milk beyond the monolayer moisture content is much higher than for pure water vaporization enthalpy. Finally, using the fitted GAB model it was possible to construct a design space for the spray drying process of goat milk, and optimal spray drying parameters were determined.Practical ApplicationsThe construction of a production design space is critical for process scale‐up. On our work, we developed a new method to build such design space using the information provided by the moisture sorption isotherm and a fundamental model for the spray drying process. Therefore, a theoretical design space can be built with minimal resources which can be very useful for new products.
Efficacy of an email‐based recording and reminding system for limiting daytime non‐functional tooth contact in patients with temporomandibular disorders: A randomized controlled trial
Authors: Takeuchi‐Sato Tamiyo , Ono Yasuhiro , Funato Masahiko , Sato Hitoshi , Suganuma Takeshi , Baba Kazuyoshi 
Published: August 2019

AbstractBackgroundOral parafunctional activities such as daytime non‐functional tooth contact (nFTC) are considered aetiological factors for temporomandibular disorders (TMD).ObjectivesTo evaluate the effectiveness of an email‐based recording and reminding system for limiting daytime nFTC in patients with TMDs.MethodsThirty patients with TMDs (mean age, 30.7 ± 8.7 years) were randomly assigned to three groups according to the intervention for limiting nFTC: cognitive behavioural therapy (CBT) with an email‐based recording and reminding system for 20 days (e‐CBT group, n = 10), CBT with a sticky note reminder for 20 days (s‐CBT group, n = 10) and simple verbal instructions to avoid nFTC that were provided before the experimental period (control group, n = 10). The frequency of nFTC, range of pain‐free unassisted mouth opening and pain intensity during painful unassisted maximum mouth opening was evaluated before and after the experimental period.ResultsThe frequency of nFTC significantly decreased after the intervention in the e‐CBT and s‐CBT groups. Among the three groups, the decrease in the nFTC frequency was the maximum in the e‐CBT group (P < .01). In addition, the range of pain‐free unassisted mouth opening showed a significant increase in all three groups, with the maximum improvement in the e‐CBT group (analysis of variance, P < .01).ConclusionsThe present findings suggest that our email‐based recording and reminding system may have the potential to effectively control daytime nFTC and could be an effective strategy for the management of TMDs.
Improv and the Angel: Disability Dance, Embodied Ethics, and Jewish Biblical Narrative
Authors: Watts Belser Julia 
Published: August 2019

AbstractDisability dance lays claim to the provocative possibilities of the disabled body, raising profound questions about the politics of art, affect, and embodiment. For scholars of religion, disability dance is a powerful—and as yet unrecognized—site for probing the sacrality and ethics enacted in disability culture. This article brings the biblical tale of Jacob and the angel into conversation with a contemporary performance, “The Way You Look (at me) Tonight,” an intimate duet between choreographer and performer Jess Curtis and Clare Cunningham, an internationally acclaimed dancer who explores the artistry of lived disability experience. Using dance as a hermeneutic invitation to draw out ethical insights into risk, consent, and intimacy, I offer a disability‐sensitive reading of Genesis 32—reading the angel as a body whose presence attests to the brilliant shock of disability difference and probing the psychic and somatic transformation that unfolds when Jacob comes into kinesthetic contact with disability and the sacred.
Caregiver satisfaction with interim silver diamine fluoride applications for their children with caries prior to operating room treatment or sedation
Authors: Cernigliaro Dana , Kumar Anjali , Northridge Mary E. , Wu Yinxiang , Troxel Andrea B. , Cunha‐Cruz Joana , Balzer Jay , Okuji David M. 
Published: August 2019

AbstractObjectiveTo ascertain caregiver satisfaction with silver diamine fluoride (SDF) application(s) as an intermediate care path for their children with caries.MethodsCaregivers were recruited at two community health centers when they arrived for a previously scheduled operating room/sedation appointment for their children with caries who had previously been treated with SDF. They were asked to complete a survey regarding their satisfaction with SDF treatment while they waited during their children's dental treatment.ResultsCaregivers overwhelmingly reported that they were satisfied with SDF treatment (81.3%), and that the black mark was not an issue for their children (91.7%) or themselves (87.5%). Moreover, their perception of their children's oral health quality of life was high.ConclusionsBy arresting caries, SDF offers an intermediate care path for pediatric patients for whom OR/sedation treatment was not immediately available. Moreover, most caregivers were satisfied with SDF treatment for their children.
The macromolecular composition of noncalcified marine macroalgae
Authors: Fiset Catherine , Irwin Andrew J. , Finkel Zoe V. 
Published: August 2019

The macromolecular composition of macroalgae influences nutrient flow and food quality in aquatic ecosystems and the value of macroalgae species for human consumption, aquaculture, biofuels, and other applications. We used literature data (125 publications, 1,117 observations) and a hierarchal Bayesian statistical model to estimate the average macromolecular composition, protein, lipid, and carbohydrate of macroalgae as a whole and at the phylum level. Our focus was on marine, noncalcified macroalgae sampled from wild‐grown populations in the field. We found that the median macromolecular composition is 9.98% protein, 2.7% lipid, 48.5% carbohydrate, and 31.8% ash as percent dry weight. We compared the median macromolecular content of macroalgae to microalgae and herbaceous plants and test for differences in macromolecular content across macroalgal phyla. Macroalgae were much more enriched in carbohydrate and minerals than the microalgae and lower in protein and lipid than many herbaceous plants. Rhodophyte macroalgae have significantly less lipid and more protein and the Ochrophyte macroalgae have significantly less protein than the average.
A century of pollination success revealed by herbarium specimens of seed pods
Authors: Duan Yuan‐Wen , Ren Haibao , Li Tao , Wang Lin‐Lin , Zhang Zhi‐Qiang , Tu Yan‐Li , Yang Yong‐Ping 
Published: August 2019

SummaryA widely observed pollinator decline around the world has led to the prediction that terrestrial ecosystems could be disrupted as plant pollination suffers, but declining pollination success has not been tested rigorously in wild plants, and it still remains unclear how pollination success of plant species responds differently in the context of pollinator decline.By viewing the number of seeds per pod as a quantitative measure of successful pollination, we examined seed pods in 4637 herbarium specimens of 109 obligately outcrossing legumes collected over the past century.We found that only 13 species showed significant temporal change with nine of those as an increase. None of the three subfamilies of legumes showed a consistent trend, and the subfamily Papilionoideae with the most specialized flowers, had increasing seed number per pod more often than decreasing.We conclude that legume pollination in China shows no sign of disruption and the effects of plant–pollinator disruption may be more complicated than simplistic predictions have allowed.
Identification of Economic Shocks by Inequality Constraints in Bayesian Structural Vector Autoregression
Authors: Lanne Markku , Luoto Jani 
Published: August 2019

AbstractTheories often make predictions about the signs of the effects of economic shocks on observable variables, thus implying inequality constraints on the parameters of a structural vector autoregression (SVAR). We introduce a new Bayesian procedure to evaluate the probabilities of such constraints, and, hence, to validate the theoretically implied economic shocks. We first estimate a SVAR, where the shocks are identified by statistical properties of the data, and subsequently label these statistically identified shocks by the Bayes factors calculated from their probabilities of satisfying given inequality constraints. In contrast to the related sign restriction approach that also makes use of theoretically implied inequality constraints, no restrictions are imposed. Hence, it is possible that only a subset or none of the theoretically implied shocks can be labelled. In the latter case, we conclude that the data do not lend support to the theory implying the signs of the effects in question. We illustrate the method by empirical applications to the crude oil market, and U.S. monetary policy.
Narrative review of reviews of preconception interventions to prevent an increased risk of obesity and non‐communicable diseases in children
Authors: Jacob Chandni Maria , Newell Marie‐Louise , Hanson Mark 
Published: August 2019

SummaryEvidence for the effect of preconception and periconceptional risk factors on childhood outcomes such as obesity and other non‐communicable diseases (NCDs) in later life is growing. Issues such as maternal malnutrition need to be addressed before pregnancy, to prevent a transgenerational passage of risk of NCDs. The aim of this review was to evidence for preconception interventions to prevent obesity and other risk factors for NCDs in children. A search for systematic reviews of interventions in the preconception period published between 2006 and 2018 was conducted on academic databases. Fifteen reviews were included, two of the reviews also included pregnant women. None of the reviews directly reported on obesity or NCD outcomes in children. Results suggest that exercise‐ and diet‐based interventions significantly reduced maternal weight postpartum, weight gain during pregnancy, and improved prevention and control of gestational diabetes. Balanced protein energy supplementation during and before pregnancy was associated with an increase in mean birth weight and reduction of low birth weight babies. There is a dearth of evidence for preconception programmes that follow up on childhood outcomes related to a risk of NCDs. Nevertheless, results suggest that women who received preconception interventions were more likely to have improved pregnancy‐related and behavioural outcomes.
Further investigations of the IgE response to tetanus and diphtheria following covaccination with acellular rather than cellular Bordetella pertussis
Authors: Aalberse Rob C. , Grüber Christoph , Ljungman Margaretha , Kakat Suzan , Wahn Ulrich , Niggemann Bodo , Nilsson Lennart J. 
Published: August 2019

AbstractBackgroundIt has previously been shown in an uncontrolled study that the IgE response to vaccine antigens is downregulated by co‐vaccination with cellular Bordetella pertussis vaccine.MethodsIn the present study, we compared in a controlled trial the humoral immune response to diphtheria toxoid (D) and tetanus toxoid (T) in relation to co‐vaccinated cellular or acellular B pertussis vaccine. IgE, IgG4, and IgG to D and T were analyzed at 2, 7, and 12 months of age in sera of children vaccinated with D and T (DT, N = 68), cellular (DTPw, N = 68), 2‐ or 5‐component acellular B pertussis vaccine (DTPa2, N = 64; DTPa5, N = 65).ResultsOne month after vaccination, D‐IgE was detected in 10% sera of DTPw‐vaccinated children, whereas vaccination in the absence of whole‐cell pertussis resulted in 50%‐60% IgE positivity. Six months after vaccination, the IgE antibody levels were found to be more persistent than the IgG antibodies. These diphtheria findings were mirrored by those for tetanus. Only minor differences between vaccine groups were found with regard to D‐IgG and T‐IgG. No immediate‐type allergic reactions were observed.ConclusionCellular (but not acellular) B pertussis vaccine downregulates IgE to co‐vaccinated antigens in infants. We assume that the absence of immediate‐type allergic reactions is due to the high levels of IgG antibodies competing with IgE antibodies.
Home Telemonitoring Improved Pain Registration in Patients With Cancer
Authors: Knegtmans Mariëtte F. , Wauben Linda S.G.L. , Wagemans Michel F.M. , Oldenmenger Wendy H. 
Published: August 2019

AbstractIntroductionFor adequate pain treatment in patients with cancer, it is important to monitor and evaluate pain regularly. Although the numeric rating scale (NRS) is implemented in hospitals in the Netherlands, pain is still not systematically registered during outpatient consultations. The aim of this study was to assess whether home telemonitoring increases pain registration in medical records of outpatients with cancer.MethodsPatients with cancer were included in the intervention group (IG) when they visited the outpatient clinic. They received a short message service and an interactive voice response on their mobile phones 3 times a week, asking them to provide their pain score (NRS). When the reported NRS pain score was ≥5, a specialized oncology nurse adapted the pain treatment when necessary. Outcomes were compared to a control group (CG) without home telemonitoring. In both groups, medical records were analyzed and data on pain and analgesics were collected.ResultsIn each group, the medical records of 54 patients were analyzed on 3 consecutive outpatient visits. In the CG, pain registration or its absence was described in 60 visits (37.0%). In the IG, pain registration or its absence was reported in 83 visits (51.2%). Patients in the IG received a prescription for analgesics significantly more often (36/54 patients [66.6%]) than did patients in the CG (18/54 patients [33.3%]), P < 0.01).ConclusionHome telemonitoring for patients with cancer significantly increases registration of pain and prescriptions of analgesics in outpatient medical records. Home telemonitoring helps to increase the awareness of pain and its management.
Transcriptional landscape of pathogen‐responsive lncRNAs in rice unveils the role of ALEX1 in jasmonate pathway and disease resistance
Authors: Yu Yang , Zhou Yan‐Fei , Feng Yan‐Zhao , He Huang , Lian Jian‐Ping , Yang Yu‐Wei , Lei Meng‐Qi , Zhang Yu‐Chan , Chen Yue‐Qin 
Published: August 2019

SummaryPlant defence is multilayered and is essential for surviving in a changing environment. The discovery of long noncoding RNAs (lncRNAs) has dramatically extended our understanding of post‐transcriptional gene regulation in diverse biological processes. However, the expression profile and function of lncRNAs in disease resistance are still largely unknown, especially in monocots. Here, we performed strand‐specific RNA sequencing of rice leaves infected by Xanthomonas oryzae pv. Oryzae (Xoo) in different time courses and systematically identified 567 disease‐responsive rice lncRNAs. Target analyses of these lncRNAs showed that jasmonate (JA) pathway was significantly enriched. To reveal the interaction between lncRNAs and JA‐related genes, we studied the coexpression of them and found 39 JA‐related protein‐coding genes to be interplayed with 73 lncRNAs, highlighting the potential modulation of lncRNAs in JA pathway. We subsequently identified an lncRNA, ALEX1, whose expression is highly induced by Xoo infection. A T‐DNA insertion line constructed using enhancer trap system showed a higher expression of ALEX1 and exerted a significant resistance to rice bacterial blight. Functional study revealed that JA signalling is activated and the endogenous content of JA and JA‐Ile is increased. Overexpressing ALEX1 in rice further confirmed the activation of JA pathway and resistance to bacterial blight. Our findings reveal the expression of pathogen‐responsive lncRNAs in rice and provide novel insights into the connection between lncRNAs and JA pathway in the regulation of plant disease resistance.
Formation of satellite uredinia as an important trait related to grapevine colonization by Phakopsora meliosmae‐myrianthae
Authors: Primiano I. V. , Loehrer M. , Schaffrath U. , Amorim L. 
Published: August 2019

Phakopsora meliosmae‐myrianthae, the causal agent of Asian grapevine leaf rust, significantly reduces the photosynthetic efficiency of grapevine leaves in green symptomless tissues surrounding lesions. This study took a close look at grapevine leaf colonization kinetics by P. meliosmae‐myrianthae and compared it to P. pachyrhizi–soybean and Uromyces appendiculatus–bean colonization. It is already known from the literature that soybean rust, similar to grapevine rust, has a negative effect on leaf photosynthesis greater than would be expected based on visual lesions. However, in contrast to soybean and grapevine rusts, the effect of bean rust on leaf photosynthesis is proportional to the diseased leaf area. Colonization progress was monitored by fungal biomass assessed via histological staining and quantitative polymerase chain reaction (qPCR). Individual lesions of P. meliosmae‐myrianthae on grapevine, P. pachyrhizi on soybean and U. appendiculatus on common bean leaves were evaluated every 3–4 days, and the number of uredinia was counted. Staining showed that mycelial colonization did not extend beyond the lesion border. The number of P. pachyrhizi and P. meliosmae‐myrianthae uredinia within the lesions increased over time (on average 14‐fold), whereas the number of U. appendiculatus uredinia remained the same. These findings were corroborated by qPCR, which revealed a greater increase in fungal biomass for Phakopsora spp. than for U. appendiculatus until 12 days post‐inoculation. The high number of satellite uredinia within lesions might be directly related to the impact of this pathogen in photosynthetic efficiency on symptomless areas of diseased grapevine leaves. This study identified accelerated formation of satellite uredinia as an important feature of grapevine colonization by P. meliosmae‐myrianthae.