bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pressure-Mediated Biofeedback With Pelvic Floor Muscle Training for Urinary Incontinence
Authors: Wang Xiuqi , Qiu Jin , Li Dan , Wang Zhongmin , Yang Yanjing , Fan Guorong , Mao Xiaoyan , Wang Jiandi , Gao Shan , Zhu Xihui , Xu Tao , Sun Zhijing 
Published: November 2024

ImportanceSupervised pelvic floor muscle training (PFMT) has been recommended as the first-line treatment for women with stress urinary incontinence (SUI), but more evidence on whether adjunctive methods would provide additional benefits is needed.ObjectiveTo compare the efficacy of PFMT with or without a home-based pressure-mediated biofeedback (BF) device.Design, Setting, and ParticipantsThis multicenter assessor-blinded randomized clinical trial was conducted in the obstetric clinics of 5 participating tertiary hospitals in China. Participants included eligible women with new-onset postpartum SUI who were enrolled from March 28, 2022, to October 13, 2023.InterventionAll participants received 3 months of supervised PFMT and were randomized to either the intervention (PFMT with a home-based pressure-mediated BF device) or the control group (home-based PFMT).Main Outcome and MeasuresThe primary outcome was the severity of urinary incontinence evaluated by the International Consultation on Incontinence Questionnaire–Urinary Incontinence Short Form after 3 months of supervised PFMT. The secondary outcomes included the cure and improvement rates, PFM strength, quality of life, self-efficacy, and adherence.ResultsA total of 452 participants (median age, 34 [IQR, 31-36] years; median body mass index [calculated as the weight in kilograms divided by the height in square meters], 23.71 [IQR, 21.37-25.97]; median time since delivery, 50 [IQR, 43-61] days) were included in the analysis, with 223 in the intervention group and 229 in the control group. Compared with the control group, the intervention group achieved a significantly greater reduction in incontinence severity (median, 3.00 [IQR, 1.00-6.00] vs 2.00 [IQR, 0-4.00] points; z = −3.05; P = .002), significantly increased cure rate (45 of 223 [20.2%] vs 20 of 229 [8.7%]; z = 12.02; P = .001) and improvement (132 of 223 [59.2%] vs 102 of 229 [44.5%]; z = 9.71; P = .002), significantly greater pelvic floor muscle strength (median, 26.00 [IQR, 17.00-38.00] vs 21.00 [IQR, 13.50-33.50] cm H2O; z = −2.28; P = .02), and a significantly greater correlation between subjective and objective adherence (r = 0.825 vs r = 0.627).Conclusion and RelevanceIn this randomized clinical trial, the efficacy of pressure-mediated BF combined with PFMT was superior to that of PFMT alone. These findings support the use of pressure-mediated BF devices for improving treatment outcomes for patients with SUI.Trial RegistrationClinicalTrials.gov Identifier: NCT05115864
Cost-Effectiveness of Temporary Financial Assistance for Veterans Experiencing Housing Instability
Authors: Nelson Richard E. , Chapman Alec , Byrne Thomas , Chaiyakunapruk Nathorn , Suo Ying , Effiong Atim , Pettey Warren , Gelberg Lillian , Kertesz Stefan G. , Tsai Jack , Montgomery Ann Elizabeth 
Published: November 2024

ImportanceThe US Department of Veterans Affairs (VA) partners with community organizations (grantees) across the US to provide temporary financial assistance (TFA) to vulnerable veterans through the Supportive Services for Veteran Families (SSVF) program. The goal of TFA for housing-related expenses is to prevent homelessness or to quickly house those who have become homeless.ObjectiveTo assess the cost-effectiveness of the SSVF program with TFA vs without TFA as an intervention for veterans who are experiencing housing insecurity.Design, Setting, and ParticipantsThis study used a Markov simulation model to compare cost and housing outcomes in a hypothetical cohort of veterans enrolled in the SSVF program. Enrollees who are homeless receive rapid rehousing services, while those who are at risk of becoming homeless receive homelessness prevention services.ExposureThe SSVF program with TFA for veterans who are experiencing housing insecurity.Main Outcomes and MeasuresThe effectiveness measure was the incremental cost-effectiveness ratio (ICER) with quality-adjusted life-years (QALYs). The model was parameterized using a combination of inputs taken from published literature and internal VA data. The model had a 2-year time horizon and a 1-day cycle length. In addition, probabilistic sensitivity analyses were conducted using 10 000 Monte Carlo simulations.ResultsThe base case analyses found that the SSVF program with TFA was more costly ($35 814 vs $32 562) and yielded more QALYs (1.541 vs 1.398) than the SSVF program without TFA. The resulting ICER was $22 676 per QALY, indicating that TFA is the preferred strategy at a willingness-to-pay threshold of $150 000 per QALY. This ICER was $19 114 per QALY for veterans in the rapid rehousing component of the SSVF program and $29 751 per QALY for those in the homelessness prevention component of the SSVF program. At a willingness-to-pay threshold of $150 000 per QALY, probabilistic sensitivity analyses showed that TFA was cost-effective in 8972 of the 10 000 Monte Carlo simulations (89.7%) for rapid rehousing and in 8796 of the 10 000 Monte Carlo simulations (88.0%) for homelessness prevention only.Conclusions and RelevanceThis economic evaluation suggests that TFA is a cost-effective approach (ie, yields improved health benefits at a reasonable cost) for addressing housing insecurity for veterans enrolling in the SSVF program. Future research could examine the cost effectiveness of large, nationwide housing interventions such as this one among subpopulations of veterans such as those with certain comorbidities including severe mental illness or substance use disorders, those with chronic diseases, or those experiencing long-term housing instability vs acute loss of housing.
Distinct neuroinflammatory patterns between cerebral microbleeds and microinfarcts in cerebral amyloid angiopathy
Authors: Puy Laurent , Barus Romain , Pasi Marco , Pétrault Maud , Deramecourt Vincent , Cordonnier Charlotte , Bérézowski Vincent 
Published: November 2024

AbstractIn this neuropathological study, we investigated neuroinflammation surrounding recent and old cerebral microbleeds (CMBs) and cerebral microinfarcts (CMIs) in 18 cases of cerebral amyloid angiopathy (CAA). We used several serial stainings and immunolabellings to identify microvascular lesions, define their recent or old stage, and characterize neuroinflammatory response (scavenging activity and astrogliosis). We found that both CMBs and CMIs induce a neuroinflammatory response, which was more pronounced in old lesion than recent. Astrogliosis and scavenging activity were differentially prominent according to the ischemic/hemorrhagic nature of the lesion. Our findings provide insights into the pathophysiology of microvascular injuries in CAA.
Optimizing Sodium Ion Adsorption Through Robust d–d Orbital Modulation for Efficient Capacitive Deionization
Authors: Yu Muran , Li Daqing , Sui Guozhe , Guo Dongxuan , Chu Dawei , Li Yue , Chai Dong‐Feng , Li Jinlong 
Published: November 2024

AbstractUnraveling the fundamental mechanisms of sodium ion adsorption behavior is crucial for guiding the design of electrode materials and enhancing the performance of capacitive deionization systems. Herein, the optimization of sodium ion adsorption is systematically investigated through the robust d–d orbital interactions within zinc‐doped iron carbide, facilitated by a novel liquid nitrogen quenching treatment. Liquid nitrogen quenching treatment can enhance the coordination number, strengthen d–d orbital interactions, promote electron transfer, and shift the d‐band center of Fe closer to the Fermi level, thereby enhancing sodium ions adsorption energy. Consequently, the obtained electrode material achieves a superior gravimetric adsorption capacity of 121.1 mg g−1 and attractive cyclic durability. The adsorption capacity is highly competitive compared to the vast majority of related research works in the field of capacitive deionization. Furthermore, sodium ion adsorption/desorption mechanisms are substantiated through ex situ techniques, revealing dynamic atomic and electronic structure evolutions under operational conditions. This work demonstrates that optimizing sodium ion adsorption via robust d–d orbital modulation enabled by liquid nitrogen quenching treatment is an effective approach for developing efficient capacitive deionization electrode materials.
Construction and 3D Printing of Multiscale Silk Fiber‐Cellulose Composite Networks Based on Ionic Liquids
Authors: Zou Chenglong , Lv Jiayi , Zhu Kai , Jiao Yidan , Rong Jinyun , Zhang Wenzhe , He Xiyang , Pan Qizhu , Zhang Xiucheng , Hua Xin , Liu Bing 
Published: November 2024

AbstractMicroscopic defects in the amorphous regions of natural cellulose affect the mechanical properties of their materials. After dissolution and regeneration, cellulose's mechanical properties are still insufficient for application in advanced materials. Conventional compounding and crosslinking techniques with toxic crosslinking agents are not only cumbersome, but also have limited performance enhancement in cellulose materials Therefore, much attention has been paid to designing and developing more straightforward and efficient cellulose reinforcement technologies. Herein, an in situ multiscalarization strategy is used to form multiscale silk fiber‐cellulose composites (MS‐C) by the gradual nanosizing of silk fibers (SF) under heating in a 1‐butyl‐3‐methylimidazolium chloride solution of cellulose (Cel‐BmimCl). MS‐C are constructed from micro and nano SF, fibroin chains, and cellulose molecules into a multidimensional network. Due to its advantage of multiscale structure, MS‐C has excellent mechanical properties, the tensile strength and Young's modulus, which are 123.06% and 91.68% higher than that of pure regenerated cellulose after 5h heating treatment. Besides, MS‐C has good biocompatibility and can be molded or 3D printed with direct ink writing, showing broad application prospects in medical, bioengineering, and other fields. This multiscale enhancement strategy can also be extended to the research and application of biopolymers such as natural polysaccharides or proteins.
Transient Optical Modulation in Vanadium and Selenium Doped MoS2 by Carrier–Carrier and Carrier–Phonon Interactions
Authors: Upadhyay Bhuvan , Maity Dipak , Anil Sreekant , Narayanan Tharangattu N. , Pal Suman Kalyan 
Published: November 2024

AbstractDoping and alloying induce defect states in atomically thin transition metal dichalcogenides (TMDCs), leading to strong carrier–phonon interactions. The robust excitonic behavior of these layered materials can be modified by injecting a high density of charge carriers. However, comprehending the influence of carrier–phonon and carrier–carrier interactions on the optical properties of 2D materials is crucial for their optoelectronic and photonic applications. Here, transient absorption (TA) spectroscopy is employed to demonstrate the modulation of the transient optical behavior of TMDCs through doping and excitation near Mott density. The TA spectra reveal broadening attributed to carrier–carrier and carrier–phonon interactions, with the broadening being particularly pronounced in vanadium (V) doped TMDCs due to the hybridization of defect and exciton transitions. Analysis of TA kinetics suggests the involvement of various carrier species in the carrier dynamics of TMDCs, with the influence of mid‐gap carriers dominating at higher excitation densities. Nonetheless, the presence of strong carrier–phonon coupling in V‐doped TMDCs is demonstrated by temperature‐dependent Raman and photoluminescence spectroscopy. The results reveal that the enhanced coupling between acoustic phonons and carriers can lead to multiphonon emission. The findings of this study hold promise for controlling the optical response of TMDCs in ultrafast optoelectronic applications.
Highly Elastic Full Hydrocarbon Ultralong RTP Polymers with Visible Light Excitable S0→T1 Population
Authors: Liu Guanyu , Zhang Shiguo , Chen Junwu , Xue Shanfeng , Sun Qikun , Yang Wenjun 
Published: November 2024

AbstractHighly elastic ultralong organic room temperature phosphorescence (RTP) polymers are highly desired in wearable optoelectronic fields, but they are hardly realized in rubbers since chain segment motions deactivate triplet excitons. In the current work, it is revealed that polystyrene (PS) can inhibit triplet thermal deactivation of coronene (Cor), and it is the serious oxygen diffusion and quenching that disables RTP emission of Cor/polymers. In view of oxygen barrier function of rubbers, PS−polyisoprene−PS tri‐block elastomers (SIS) are used as Cor's doping matrices. The results show that Cor/SIS sheets show bright and ultralong afterglow with RTP lifetime up to 3.64 s in air after brief 365 nm light excitation. More impressively, Cor/SIS and its red fluorescent dye doped sheets all exhibit ultralong room temperature afterglow under large dynamic elastic deformation. Further, all these sheets exhibit long‐wave blue light excited afterglow despite Cor/SIS having no visible light absorption band, and the unique photoexcitation and emission mechanism is verified. This work not only provides the development strategy of the latest elastic RTP materials, but also will evoke a fresh understanding on organic doped RTP polymers.
Oxygen Vacancy Sites Enable Efficient Photocatalytic Oxidation of Nitric Oxide: The Role of W/Mo Valence Transition in Bi2W(Mo)O6‐x
Authors: Yang Chaoyang , Zhang Junlei , Yu Guojia , Zhu Mingshan , Ravi Sai Kishore 
Published: November 2024

AbstractOxygen vacancy (Ov) sites play a critical role in the activation and deep oxidation of nitric oxide (NO). However, controlling the concentration and type of Ov remains a significant challenge. In this study, Bi2W(Mo)O6‐x is investigated as a model system and demonstrates that increasing the concentration of Ov substantially enhances the efficiency of air NO removal. Increasing the Ov concentrations in Bi2WO6‐x and Bi2MoO6‐x improves NO removal efficiency ≈12‐ and 11‐fold, respectively, compared to their low‐Ov counterparts. This enhancement is attributed to improved adsorption and activation of NO/O2 molecules, better separation and transfer of photogenerated carriers, and increased visible light absorption. Notably, Bi2WO6‐x remains highly stable over ten recycling tests for continuous air NO deep photooxidation, while Bi2MoO6‐x shows a 43.5% decrease in efficiency after ten runs. This sustained performance is attributed to stable Ovs without changes in metal ion valence, unlike Bi2MoO6‐x, where instability arises from the reduction of Mo6+ to Mo4+. In situ DRIFTS reveals possible pathways for the deep photooxidation of NO to nitrate (NO3−). This study provides valuable insights into designing high‐performance, durable catalysts by effectively controlling Ov concentration and type, paving the way for efficient photocatalytic air purification technologies.
Virtual screening of plant‐derived molecules against zinc‐dependent imipenemases in class B metallo‐β‐lactamases of Acinetobacter baumannii
Authors: Gopikrishnan Mohanraj , Doss C George Priya 
Published: November 2024

AbstractMetallo‐β‐lactamases (MBLs), enzymes of class B, employ zinc ions to degrade β‐lactam antibiotics such as penicillins, cephalosporins, carbapenems, and cephamycins. Carbapenem‐resistant Acinetobacter baumannii (CRAB) is linked to the existence of carbapenemase enzymes such as oxacillinase and MBL. The most prevalent resistance mechanisms include imipenemases (IMP), verona integron‐encoded MBL, and New Delhi MBL‐1. The effectiveness of current antibiotics against the MBL enzyme is limited due to the presence of metal ions, underscoring the need for new antimicrobial agents. Recent research has demonstrated that natural compounds can effectively inhibit MBL. This study aims to screen natural phytochemicals against IMP‐2 MBL using in silico virtual screening techniques via AutoDock Vina and molecular dynamic simulations with GROMACS for 200 ns, followed by molecular mechanics/Poisson‒Boltzmann surface area analysis. This procedure identified new lead molecules against A. baumannii that produce IMP. A total of 588 natural compounds were screened against IMP, along with the imipenem substrate and known inhibitors of L‐captopril. The top four compounds, N025‐0038 (NC1), N062‐0008 (NC2), eupalitin, and Rosmorinic acid, demonstrated binding affinities of ‒8.5, ‒8.4, ‒7.5, and ‒7.2 kcal/mol, respectively. The structural stability of these complexes was observed to be maintained throughout the simulation in a dynamic environment, as determined by molecular dynamics trajectory analysis, and all these compounds met the SWISS‐ADME (adsorption, distribution, metabolism, and excretion) properties. NC1 and NC2 compounds are considered potential drug molecules against IMP. However, while these selected compounds showed superior binding energy in computational analysis, further in vitro analysis is required to establish an effective drug regimen against A. baumannii that produces IMP.
Digital transformation, environmental regulation and enterprises' ESG performance: Evidence from China
Authors: Wang Jie 
Published: November 2024

AbstractCompany's digital transformation and Environmental, social, and governance (ESG) performance are crucial for their development, but there is little literature that considers whether and how digital transformation improve ESG performance, the impact of environmental regulations is also easily overlooked, we attempt to fill this gap. Based on data related to Chinese listed enterprises from 2011 to 2020, we focus on the internal digital transformation of enterprises, analyze and empirically test the direct and mediating influence of digital transformation on enterprises' ESG performance, as well as the moderating effect of external environmental regulations. The results show that digital transformation improves ESG performance. Heterogeneity analysis found that digital transformation had different impacts on different dimensions of enterprise ESG performance. Further analysis indicates that enterprises' green innovation and labor demand play a mediating role in the relationship between enterprises' digital transformation and ESG performance. Regional formal environmental regulation and informal environmental regulation moderates the path of firms' digital transformation promoting green innovation level to enhance ESG performance. This paper provides micro evidence in China for exploring the improvement of enterprises' ESG performance and provides relevant ideas for understanding the effect of digital transformation.
Differences in Immune Cell‐Derived Circular RNA Between Fulminant Type 1 Diabetes and Type 1 Diabetes
Authors: Yin Wenfeng , Luo Shuoming , Qiu Junlin , Xiao Zilin , Zhang Ziwei , Wang Rui , Xie Zhiguo , Li Xia , Zhou Zhiguang 
Published: November 2024

ABSTRACTAimsCircular RNAs (circRNAs) are associated with fulminant type 1 diabetes (FT1D) and type 1 diabetes (T1D). However, the differences in circRNAs between FT1D and T1D remain unclear. Our objective is to identify peripheral blood mononuclear cells (PBMCs)‐derived circRNAs in FT1D and T1D and explore their potential functions.Materials and methodsPBMCs were extracted from six patients with FT1D and age‐, sex‐, and duration‐matched T1D patients. The Arraystar Human circRNA Array was utilised to obtain circRNA expression profiles. Seven aberrantly expressed circRNAs were selected for determining expression levels in another independent cohort (FT1D subjects n = 35, T1D subjects n = 70, and controls n = 100) using real‐time quantitative PCR (RT‐qPCR). Biological functions, circRNA‐miRNA‐mRNA networks, and the coding potential of circRNAs were predicted through bioinformatics analysis.ResultsIn total, 145 differentially expressed circRNAs were identified in FT1D and T1D, with 63 upregulated and 82 downregulated circRNAs. Hsa_circRNA_038288, hsa_circRNA_104405, and hsa_circRNA_405498 were successfully validated among the 7 aberrantly expressed circRNAs selected to determine expression levels. Bioinformatics analysis revealed that majority of the parent genes of circRNAs are enriched in signalling pathways such as RNA transport, ubiquitin‐mediated proteolysis, and focal adhesion. Hsa_circRNA_038288 appears to play a role in 51 circRNA‐miRNA‐mRNA signalling pathways associated with immune regulation and diabetes. Additionally, hsa_circRNA_038288 potentially exhibits coding potential and is involved in the progression of both FT1D and T1D.ConclusionsSignificant differences in immune cell‐derived circRNAs were found between FT1D and T1D patients, offering novel insights into the molecular mechanisms that distinguish FT1D from T1D.
Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy
Authors: Li Qinghong , Homilius Max , Achilles Erin , Massey Laura K. , Convey Victoria , Ohlsson Åsa , Ljungvall Ingrid , Häggström Jens , Boler Brittany Vester , Steiner Pascal , Day Sharlene , MacRae Calum A. , Oyama Mark A. 
Published: November 2024

AbstractBackground and aimsThe heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress. Hypertrophic cardiomyopathy (HCM) is a common heart condition, affecting approximately 15% of the general cat population. Feline HCM shares phenotypical and genotypical similarities with human HCM, but the disease mechanisms for both species are incompletely understood. Our goal was to characterize global changes in metabolome between healthy control cats and cats with different stages of HCM.MethodsSerum samples from 83 cats, the majority (70/83) of which were domestic shorthair and included 23 healthy control cats, 31 and 12 preclinical cats with American College of Veterinary Internal Medicine (ACVIM) stages B1 and B2, respectively, and 17 cats with history of clinical heart failure or arterial thromboembolism (ACVIM stage C), were collected for untargeted metabolomic analysis. Multiple linear regression adjusted for age, sex and body weight was applied to compare between control and across HCM groups.ResultsOur study identified 1253 metabolites, of which 983 metabolites had known identities. Statistical analysis identified 167 metabolites that were significantly different among groups (adjusted P < 0.1). About half of the differentially identified metabolites were lipids, including glycerophospholipids, sphingolipids and cholesterol. Serum concentrations of free fatty acids, 3‐hydroxy fatty acids and acylcarnitines were increased in HCM groups compared with control group. The levels of creatine phosphate and multiple Krebs cycle intermediates, including succinate, aconitate and α‐ketoglutarate, also accumulated in the circulation of HCM cats. In addition, serum levels of nicotinamide and tryptophan, precursors for de novo NAD+ biosynthesis, were reduced in HCM groups versus control group. Glutathione metabolism was altered. Serum levels of cystine, the oxidized form of cysteine and cysteine‐glutathione disulfide, were elevated in the HCM groups, indicative of heightened oxidative stress. Further, the level of ophthalmate, an endogenous glutathione analog and competitive inhibitor, was increased by more than twofold in HCM groups versus control group. Finally, several uremic toxins, including guanidino compounds and protein bound putrescine, accumulated in the circulation of HCM cats.ConclusionsOur study provided evidence of deranged energy metabolism, altered glutathione homeostasis and impaired renal uremic toxin excretion. Altered lipid metabolism suggested perturbed structure and function of cardiac sarcolemma membrane and lipid signalling.