bluuebunny/crossref_metadata_2025_split huggingface dataset:
The midline approach for endotracheal intubation using GlideScope video laryngoscopy could provide better glottis exposure in adults： A randomized controlled trial
Authors: Jiang Lianxiang , Qiu Shulin , Zhang Peng , Yao Weidong , Chang Yan , Dai Zeping 
Published: October 2019

Abstract
Background: Previous studies have demonstrated that the common laryngoscopic approach (right-sided) and midline approach are both used for endotracheal intubation by direct laryngoscopy. Although the midline approach is commonly recommended for video laryngoscopy (VL) in the clinic, there is a lack of published evidences to support this practice. This study aimed to evaluate the effects of different video laryngoscopic approaches on intubation.
Methods: Two hundred sixty-two patients aged 18 years who underwent elective surgery under general anaesthesia and required endotracheal intubation were included in the present prospective, randomized, controlled study. The participants were randomly and equally allocated to the right approach (Group R) or midline approach (Group M). All the intubations were conducted by experienced anaesthetists using GlideScope video laryngoscopy. The primary outcomes were Cormack-Lehane laryngoscopic views (CLVs) and first-pass success (FPS) rates. The secondary outcomes were the time to glottis exposure, time to tracheal intubation, haemodynamic responses and other adverse events. Comparative analysis was performed between the groups.
Results: Finally, 262 patients completed the study, and all the tracheas were successfully intubated. No significant differences were observed in the patient characteristics and airway assessments ( P >0.05). Compared with Group R, Group M had a better CLV ( χ2 =14.706, P =0.001) and shorter times to glottis exposure (8.82±2.04 vs 12.38±1.81; t =14.94; P <0.001) and tracheal intubation (37.19±5.01 vs 45.23±4.81; t =13.25; P <0.001), but no difference was found in the FPS rate (70.2% vs 71.8%; χ2 =0.074; P =0.446) and intubation procedure time (29.86±2.56 vs 30.46±2.97, t =1.75, P =0.081). Between the groups, the rates of hoarseness or sore throat, minor injury, hypoxemia and changes in SBP and HR showed no significant difference ( P >0.05).
Conclusion: Although the FPS rate did not differ based on the laryngoscopic approach, the midline approach could provide better glottis exposure and shorter times to glottis exposure and intubation. The midline approach should be recommended for teaching in VL-assisted endotracheal intubation.
Trial registration: The study was registered in the Chinese Clinical Trial Registry ( ChiCTR-RNC-1900023252 ).
Current Designs and Developments of Fucoidan-based Formulations for Cancer Therapy
Authors: Tran Phuong H.L. , Tran Thao T.D. 
Published: October 2019

Background:
Natural nanostructure materials have been involved in antitumor drug delivery systems due
to their biocompatibility, biodegradation, and bioactive properties.

Methods:
These materials have contributed to advanced drug delivery systems in the roles of both bioactive compounds
and delivery nanocarriers. Fucoidan, a valuable ocean material used in drug delivery systems, has been exploited
in research on cancer and a variety of other diseases.

Results:
Although the uniqueness, structure, properties, and health benefits of fucoidan have been mentioned in
various prominent reviews, current developments and designs of fucoidan-based formulations still need to be assessed
to further develop an effective anticancer therapy. In this review, current important formulations using fucoidan
as a functional material and as an anticancer agent will be discussed. This article will also provide a brief
principle of the methods that incorporate functional nanostructure materials in formulations exploiting fucoidan.

Conclusion:
Current research and future perspectives on the use of fucoidan in anticancer therapy will advance innovative
and important products for clinical uses.
Contemporary Progress in the Synthetic Strategies of Imidazole and its Biological Activities
Authors: Soni Jay , Sethiya Ayushi , Sahiba Nusrat , Agarwal Dinesh K. , Agarwal Shikha 
Published: October 2019

:Heterocyclic compounds are pervasive in many areas of life and one of the heterocycles, imidazole is a unique heterocyclic five-membered aromatic compound having two sp2 hybridized nitrogen atoms. Its integral name is 1, 3 diazole and previously, it was known as glyoxalin. This moiety has achieved a considerable place among scientists in recent years by reason of its divergent synthetic strategies and uncommon biological and pharmacological activities, for example, anti-convulsant, anti-microbial, anti-cancer, anti-inflammatory, anti-tumor, anti-viral, anti-ulcer, analgesic, etc. Due to distinct therapeutic actions, it is still an engrossed area of research. Researchers currently are inventing new greener methods to synthesize its derivatives and to improve its pharmacological activities. The purpose of this review is to study the literature that can help researchers to explore this area, its prevailing program for synthesis in environmentally friendly conditions and biological profile throughout past decades.
Evaluation of Contrast-enhanced Transcranial Color-coded Duplex Sonography (CE-TCCD) Applied in Stroke Patients with Intracranial Collateral Circulation
Authors: Xing Jin , Xu Bin , Zhai Lin , Men Yan , Zhang Dan , Zhang Wenjing , Cui Jian 
Published: October 2019

Background and Introduction:
Collateral circulation is very crucial for the prognosis
of stroke patients. Transcranial color-coded duplexsonography (TCCD) is used widely to evaluate
the intracranial arterial blood flow. However, approximately 20% - 30% of the patients with cerebral
infarction cannot be detected via TCCD due to the interruption of thickened temporal bones.
We assessed the diagnostic efficacy of contrast-enhanced transcranial color-coded duplexsonography
(CE-TCCD) in stroke patients with limited bone windows.

Methods:
CE-TCCD was applied to 70 patients (51 males and 19 females) who presented with
ischemic symptoms, to detect the openness of the anterior communicating artery (ACoA) and posterior
communicating artery (PCoA) of the Willis ring before Computed Tomography angiography
(CTA) or Magnetic Resonance Angiography (MRA) examination. The results from CETCCD
is used to compare with CTA/MRA result to verify the diagnostic efficacy.

Results:
Forty-one communicating artery openings were detected by CE-TCCD, among which 37
were PCoA and 4 were ACoA. Among the 70 patients, 23 of 70 patients indicated severe stenosis
within intracranial and/or extracranial arteries. Eighteen out of the 23 patients showed collateral
circulation, accounting for 78.3% (18/23). Moderate stenosis were 23 cases in total, in which 7
cases showed collateral circulation, accounting for 30.4% (7/23). Slight stenosis were 24 cases in
total, none of which showed collateral circulation.

Conclusion :
In the stroke patients with limited bone windows, CE-TCCD can evaluate intracranial
collateral circulation.
Ionic Liquids with Anti-Candida and Anticancer Dual Activity as Potential N-Myristoyltransferase Inhibitors
Authors: Metelytsia Larysa , Trush Maria , Semenyuta Ivan , Rogalsky Sergiy , Kobzar Oleksandr , Kalashnikova Larisa , Blagodatny Volodymyr , Hodyna Diana 
Published: October 2019

Background:
Currently, a study on the relationship between candidiasis and cancer has been
conducted. Until recent years, the opportunistic fungus C. albicans is mainly associated with cancer
processes and is able to stimulate carcinogenesis and metastasis.

Methods:
A number of ionic liquids as potential anticancer and anti-Candida agents have been investigated
based on modern theoretical and experimental data about the relationship between oncopathology
and candida infection.

Results:
The analysis of the received experimental results demonstrates that ionic liquid with alkyl
chain length of 6 carbon atoms (C6) has not shown anti-Candida activity. The indicators of its cytotoxicity
ІС50 (28,617μМ) and MTC (9,050 μМ) against HEP-2 tumor cell line were also very low. Compounds
with alkyl chain length C12 have shown high potential of anti-Candida activity and anticancer
properties.

Conclusion:
Based on the obtained results, сompound 4 (C12C1IM-Cl) is proposed for further study as a
potential double-acting agent with high anticancer and anti-Candida activities. N-myristoyltransferase is
presented and used for docking as a potential molecular target responsible for the dual anti-Сandidа and
anticancer activities of studied ionic liquids.
Pharmacokinetic Characterization of ZT55, A Novel Indole Derivative Isolated from Radix Isatidis, using Liquid Chromatography/Tandem Mass and Q-TOF/Tandem Mass Spectrometry
Authors: Dan Zhang , Min Hu , Chengbo Xu , Chengjuan Chen , Jiangong Shi , Tiantai Zhang , Pengmei Li 
Published: October 2019

Background:
ZT55 is a novel natural product isolated from Radix isatidis. It is a highlyselective
tyrosine kinase inhibitor against myeloproliferative neoplasms. Although earlier research has
described the pharmacodynamic properties of ZT55 in vivo and in vitro, the quantitative determination
and pharmacokinetic profile in vivo have not been thoroughly studied.

Methods:
A novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed
and validated for the quantification of ZT55 in rat plasma. A Waters symmetry C18 column was
used for chromatographic separation; 0.1% formic acid in acetonitrile and 0.1% formic aqueous solution
was used as the mobile phase. Detection was performed by Multiple Reaction Monitoring (MRM)
mode using electrospray ionization in the positive ion mode. UPLC-QTOF-MS was used for the identification
of metabolites.

Results:
The method was linear (R2=0.9988) over the concentration range of 1-2500 ng/mL. The lower
limit of quantification was 1 ng/mL. The intra-day and inter-day precision of ZT55 showed a relative
standard deviation within 8.47%, whereas the accuracy (RE) ranged from -4.84% to 4.45%. The recoveries
ranged from 92.89% to 97.21%. ZT55 reached the highest plasma concentration at 0.5h. The peak
concentrations with three dosages were 103.59±10.11, 185.23±29.56, and 355.98±28.86 ng/mL. The
AUC0-24 of three dosages were 874.70±72.33, 433.80±49.33, and 231.65±19.41 ng•h/ml respectively.
Five metabolites of ZT55 from plasma were confirmed. The main pathways of ZT55 in vivo were hydrolysis,
N-dealkylation, glycosylation, and sulfonation.

Conclusions:
LC-MS/MS method was successfully applied to the pharmacokinetic study of ZT55 after
oral administration and intravenous. ZT55 exhibited rapid oral absorption, high elimination, and low
absolute bioavailability. This study provides important pharmacokinetic and metabolism information
for further pharmacological and toxicological research on ZT55.
Antibacterial Effect of Peruvian Propolis Collected During Different Seasons on the Growth of Streptococcus Mutans
Authors: Becerra Thalia B. , Calla-Poma Roger D. , Requena-Mendizabal Margarita F. , Millones-Gómez Pablo A. 
Published: October 2019

Introduction:Propolis is a gummy, resinous substance made by bees from the buds and exudates of plants. The antibacterial activity of propolis has been widely studied and is known to vary according to its geographical origin, the type of surrounding flora, the collecting bee species, the mode of its collection and even the season in which it is collected. Unfortunately, these observations have not been corroborated experimentally.Aim:To compare the antibacterial activities of ethanolic extracts of propolis collected in the summer and autumn on the growth ofStreptococcus mutansATCC 25175.Materials and Methods:Propolis samples were collected in the summer and autumn and labeled “A” or “B” by an individual who was not directly involved in the study. Then, 5% ethanolic extracts of propolis were prepared for each sample.S. mutanswas plated onto brain heart infusion agar plates into which wells were formed, and the plates were divided into four groups to test the antibacterial effectiveness of both the extracts and the positive (0.12% chlorhexidine digluconate) and negative (96% ethanol) controls.Results:Inhibition halos of 26.4±2.6 and 18.2±1.8 mm were observed for the autumn and summer propolis extracts, respectively, while those of the negative and positive controls were 0 and 13 mm, respectively. These differences were statistically analyzed using Student’s t-test.Conclusion:The significantly higher growth ofS. mutansin the extracts made from propolis collected in autumn than that grown on extracts collected in summer indicates that the season in which propolis is collected does indeed influence its antibacterial activity.
Towards a Stakeholder-Oriented Blockchain-Based Architecture for Electronic Health Records: Design Science Research Study
Authors: Beinke Jan Heinrich , Fitte Christian , Teuteberg Frank 
Published: October 2019

Background
Data security issues still constitute the main reason for the sluggish dissemination of electronic health records (EHRs). Given that blockchain technology offers the possibility to verify transactions through a decentralized network, it may serve as a solution to secure health-related data. Therefore, we have identified stakeholder-specific requirements and propose a blockchain-based architecture for EHRs, while referring to the already existing scientific discussions on the potential of blockchain for use in EHRs.

Objective
This study aimed to introduce blockchain technology for EHRs, based on identifying stakeholders and systematically eliciting their requirements, and to discuss the key benefits (KBs) and key challenges (KCs) of blockchain technology in the context of EHRs.

Methods
The blockchain-based architecture was developed in the framework of the design science research paradigm. The requirements were identified using a structured literature review and interviews with nine health care experts. Subsequently, the proposed architecture was evaluated using 4 workshops with 15 participants.

Results
We identified three major EHR stakeholder groups and 34 respective requirements. On this basis, we developed a five-layer architecture. The subsequent evaluation of the artifact was followed by the discussion of 12 KBs and 12 KCs of a blockchain-based architecture for EHRs. To address the KCs, we derived five recommendations for action for science and practice.

Conclusions
Our findings indicate that blockchain technology offers considerable potential to advance EHRs. Improvements to currently available EHR solutions are expected, for instance, in the areas of data security, traceability, and automation by smart contracts. Future research could examine the patient’s acceptance of blockchain-based EHRs and cost-benefit analyses.
The Effect of a Cellular-Enabled Glucose Meter on Glucose Control for Patients With Diabetes: Prospective Pre-Post Study
Authors: Bollyky Jennifer B , Melton Stephanie T , Xu Tong , Painter Stefanie L , Knox Brian 
Published: October 2019

Background
Diabetes is a global epidemic affecting approximately 30 million people in the United States. The World Health Organization recommends using technology and telecommunications to improve health care delivery and disease management. The Livongo for Diabetes Program offers a remote monitoring technology with Certified Diabetes Educator outreach.

Objective
The purpose of this study was to examine health outcomes measured by changes in HbA1c, in time in target blood glucose range, and in depression symptoms for patients enrolled in a remote digital diabetes management program in a Diabetes Center of Excellence setting.

Methods
The impact of the Livongo for Diabetes program on hemoglobin A1c (HbA1c), blood glucose ranges, and depression screening survey results (Patient Health Questionnaire-2 [PHQ-2]) were assessed over 12 months in a prospective cohort recruited from the University of South Florida Health Diabetes Home for Healthy Living. Any patient ≥18 years old with a diagnosis of diabetes was approached for voluntary inclusion into the program. The analysis was a pre-post design for those members enrolled in the study. Data was collected at outpatient clinic visits and remotely through the Livongo glucose meter.

Results
A total of 86 adults were enrolled into the Livongo for Diabetes program, with 49% (42/86) female, an average age of 50 (SD 15) years, 56% (48/86) with type 2 diabetes mellitus, and 69% (59/86) with insulin use. The mean HbA1c drop amongst the group was 0.66% (P=.17), with all participants showing a decline in HbA1c at 12 months. A 17% decrease of blood glucose checks <70 mg/dL occurred concurrently. Participants with type 2 diabetes not using insulin had blood glucose values within target range (70-180 mg/dL) 89% of the time. Participants with type 2 diabetes using insulin were in target range 68% of the time, and type 1 diabetes 58% of the time. Average PHQ-2 scores decreased by 0.56 points during the study period.

Conclusions
Participants provided with a cellular-enabled blood glucose meter with real-time feedback and access to coaching from a certified diabetes educator in an outpatient clinical setting experienced improved mean glucose values and fewer episodes of hypoglycemia relative to the start of the program.
Effect of Polybag size on growth of dwarf and tall type of Arabica Coffee seedling
Authors: Nur Abdul Mukti 
Published: October 2019

Penelitian untuk mempelajari pengaruh ukuran polibag terhadap pertumbuhan bibit kopi Arabika tipe Kate (dwarf) dan jagur (tall) baik di pembibitan maupun setelah dipindah ke lapangan telah dilaksanakan di Kebun Percobaan Kaliwining, Pusat Penelitian Perkebunan Jember.
Bibit kepelan kopi Arabika CIFC 520-3 dengan tipe pertumbuhan kate dan BP 429 A yang bertipe jagur dipindah ke dalam 4 macam ukuran polybag yang telah diisi medium campuran tanah, pupuk kandang dan pasir dengan perbandingan 1:1:1. Empat macam ukuran (lay-flat) polibag yang digunakan, yaitu 11 cm x 30 cm, 15 cm x 30 cm, 18 cm x 30 cm, dan 20 cm x 30 cm. Bibit ditanam dengan jarak 25 cm x 25 cm dan diatur menurut rancangan acak lengkap berkelompok dalam 5 ulangan. Tiap ulangan tendiri dari 10 tanaman. Perlakuan disusun secara faktorial. Pengamatan pertumbuhan pada fase pembibitan dilakukan pada umur 3 dan 5 bulan, meliputi tinggi bibit, diameter batang, jumlah daun, jumlah cabang primer, dan bahan kering (bio-mass) tanaman. Pemindahan bibit ke lapangan dilakukan pada umur 5 bulan. Bibit ditanam dibawah naungan lamtoro yang sudah berfungsi baik dengan jarak 1,5 m x 1,5 m. Lubang tanam berukuran 60 cm x 60 cm x 60 cm. Pertumbuhan diamati pada umur 5 bulan setelah pemindahan, meliputi tinggi tanaman, diameter batang, dan jumlah cabang primer.
Hasil pengamatan menunjukkan bahwa sampai dengan umur 5 bulan tidak terdapat pengaruh interaksi antara ukuran polybag dengan tipe pertumbuhan bibit. Pertumbuhan bibit dalam polibag ukuran 15 cm x 30 cm tidak berbeda dengan yang berukuran 20 cm x 30 cm dan secara statistik lebih baik dari pada yang ditumbuhkan pada polybag berukuran 11 cm x 30 cm. Namun, pertumbuhan bibit dalam polibag ukuran 11 cm x 30 cm pada umur 5 bulan di lapangan tidak berbeda dengan ukuran polibag lainnya, menunjukkan bahwa di dataran rendah bibit kopi Arabika yang ditumbuhkan dalam polybag berukuran 11 cm x 30 cm pada umur 5 bulan secara agronomis sudah memenuhi syarat untuk dipindah ke lapangan. Dengan demikian, untuk pembibitan kopi Arabika dapat digunakan polybag ukuran 11 cm x 30 cm atau 15 cm x 30 cm.
Pertumbuhan bibit CIFC 520-3 lebih pendek dari pada BP429 A, tetapi memiliki daun dan cabang primer lebih banyak. Sedangkan pertumbuhan diameter batang, akar, dan bahan kering sampai dengan umur 5 bulan tidak berbeda.
A Study on cocoa (Theobroma cacao L.) budding V. The influence of rootstocks on scion-yield quality
Authors: Prawoto Adi 
Published: October 2019

Tulisan ini merupakan kelanjutan hasil penelitian yang telah ditulis sebelumnya. Analisis mutu biji dilaksanakan pada panenan umur 7 tahun.
Hasilnya menunjukkan bahwa batang bawah kakao tidak berpengaruh nyata pada mutu fisik maupun mutu kimiawi hasil biji batang atas. Akan tetapi ada petunjuk bahwa batang bawah sedikit memodifikasi harkat mutu tersebut lewat perubahan vigor. Ada kemungkinan mutu hasil akan terpengaruh jika dipakai batang bawah yang lebih jauh hubungan kekerabatannya.
Berkaitan dengan hal itu maka kakao yang bermutu tinggi dapat dihasilkan dari lingkungan yang bermasalah dengan cara okulasi asalkan tersedia batang bawah yang toleran kondisi tersebut.
Preliminary research of the effect of shading and pruning on cocoa production
Authors: Winarsih Sri 
Published: October 2019

Penelitian untuk mengetahui pengaruh tingkat naungan dan frekuensi pemangkasan pada kakao telah dilakukan di Perkebunan Jatirono PTP XXVI. Penelitian dilakukan pada tanaman kakao umur 9 tahun. Jarak tanam 3 x 3 m. Perlakuan merupakan kombinasi antara jumlah populasi penaung dengan frekuensi pemangkasan. Empat tingkat kerapatan penaung masing-masing 0 pohon/ha (tanpa naungan), 69 pohon/ha (Jarak tanam 12 X 12 m), 138 pohon/ha (jarak tanam 6 X 12 m), 277 pohon/ha (jarak tanam 6 X 6m). Frekuensi pemangkasan ada 3, yaitu : setiap bulan, setiap dua bulan dan setiap 3 bulan, sehingga keseluruhan terdapat 12 kombinasi perlakuan.
Hasil penelitian sampai dengan tahun ketiga setelah perlakuan menunjukkan bahwa naungan berpengaruh nyata terhadap daya hasil pada pengamatan tahun pertama, akan tetapi tidak berpengaruh nyata pada pengamatan tahun kedua dan ketiga. Terdapat kecenderungan bahwa jarak tanam penaung 6 X 6 m memberikan pengaruh paling baik dibandingkan perlakuan lainnya. Dibandingkan dengan jarak tanam 12 X 12 m, kenaikan daya hasil mencapai 14,36 dan 38% untuk tiga tahun pengamatan. Untuk perlakuan pemangkasan, sampai dengan tahun ketiga pengamatan belum menunjukkan pengaruh yang nyata. Tanaman kakao yang tidak dinaungi pada awal pengamatan mempunyai Indeks Luas Daun (ILD) paling tinggi. Nilai tersebut menurun pada pengamatan tahun berikutnya karena adanya serangan Colletotrichum.
POLÍTICAS E CURRÍCULO NA LICENCIATURA EM ARTES VISUAIS: pesquisas do Observatório da Formação de Professores no âmbito do Ensino de Arte (OFPEA/BRARG)
Authors: Silva Maria Cristina Da Rosa Fonseca da , Foerste Gerda Margit Schütz 
Published: October 2019

O presente Dossiê resulta de pesquisas do Observatório da Formação de Professores no âmbito do Ensino de Arte (OFPEA/BRARG) e da Rede Latino-Americana de Investigadores em Formação de Professores de Artes (LAIFOPA). Analisa, a partir da atual conjuntura, propostas dos currículos de formação de professores de Artes Visuais no Brasil e América Latina. Os estudos orientam-se pelo conceito de práxis na abordagem do materialismo histórico dialético. Busca discutir processos sociais que engendram diferentes proposta curriculares nacionais e internacionais de formação de professores das Artes. Agrega textos de pesquisadores da região norte, sul, centro-oeste, sudeste e nordeste brasileiro e de pesquisador Argentino, integrantes do observatório. Os resultados das pesquisas são sistematizados com o objetivo de dimensionar mudanças e continuidades nos currículos da formação de professores de Artes Visuais e problematizar propostas curriculares contemporâneas que cerceiam a autonomia e a liberdade de criação na formação docente.