bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toxicokinetics of citreoviridinin vivoandin vitro
Authors: Uchiyama Yosuke , Takino Masahiko , Noguchi Michiko , Shiratori Nozomi , Kobayashi Naoki , Sugita-Konishi Yoshiko 
Published: March 2019

AbstractCitreoviridin (CIT) produced byPenicillium citreonigrumas a secondary metabolite is a yellow rice toxin that has been reported to be related to acute cardiac beriberi; however, its toxicokinetics remain unclear. The present study elucidated the toxicokinetics through swinein vivoexperiments and predicted the human toxicokinetics by a comparison with findings fromin vitroexperiments. Swinein vivoexperiments revealed that CIT had a high bioavailability of more than 90%. In addition, it showed a large volume of distribution (1.005 ± 0.195 L/kg) and long elimination half-life (17.7 ± 3.3 h) in intravenous. These results suggested the possibility of a slow metabolism of CIT. An intestinal permeability study using the human cell line Caco-2 showed that CIT had a high permeability coefficient, suggesting it would be easily absorbed in human intestine, similar to its absorption in swine. The metabolite profiles were investigated by incubating CIT with S9 obtained from swine and humans. Hydroxylation, methylation, desaturation and dihydroxylation derivatives were detected as the predominant metabolites, and CIT glucuronide was produced slowly compared with above metabolites. A comparison of the peak area ratios obtained using quadrupole time-of-flight mass spectrometer showed that the rates of all of the main metabolites except for glucuronide produced using human S9 were three-fold higher than those obtained using swine S9. Furthermore, the elimination of CIT using human S9 was more rapid than when using swine S9, indicating that CIT would be metabolized faster in humans than in swine. Thesein vivoresults suggested that CIT is easily absorbed in swine and persists in the body for a long duration. Furthermore, the CIT metabolism appeared to be faster in human liver than in swine liverin vitro, although the bioavailability of CIT was predicted to be similarly high in humans as in swine.
Enhancements in conceptual electric aircraft design
Authors: Mieloszyk Jacek , Tarnowski Andrzej 
Published: March 2019

PurposeThis paper aims to describe the enhancement of the numerical method for conceptual phase of electric aircraft design.Design/methodology/approachThe algorithm provides a balance between lift force and weight of the aircraft, together with drag and thrust force equilibrium, while modifying design variables. Wing geometry adjustment, mass correction and performance estimation are performed in an iterative process.FindingsAircraft numerical model, which is most often very simplified, has a number of new improvements. This enables to make more accurate analyses and to show relationships between design parameters and aircraft performance.Practical implicationsThe presented approach can improve design results.Originality/valueThe new methodology, which includes enhanced numerical models for conceptual design, has not been presented before.
Application of a new local effective constrained response surface method in structural reliability optimization design
Authors: Su Hailiang , Lan Fengchong , He Yuyan , Chen Jiqing 
Published: March 2019

Purpose
Meta-model method has been widely used in structural reliability optimization design. The main limitation of this method is that it is difficult to quantify the error caused by the meta-model approximation, which leads to the inaccuracy of the optimization results of the reliability evaluation. Taking the local high efficiency of the proxy model, this paper aims to propose a local effective constrained response surface method (LEC-RSM) based on a meta-model.

Design/methodology/approach
The operating mechanisms of LEC-RSM is to calculate the index of the local relative importance based on numerical theory and capture the most effective area in the entire design space, as well as selecting important analysis domains for sample changes. To improve the efficiency of the algorithm, the constrained efficient set algorithm (ESA) is introduced, in which the sample point validity is identified based on the reliability information obtained in the previous cycle and then the boundary sampling points that violate the constraint conditions are ignored or eliminated.

Findings
The computational power of the proposed method is demonstrated by solving two mathematical problems and the actual engineering optimization problem of a car collision. LEC-RSM makes it easier to achieve the optimal performance, less feature evaluation and fewer algorithm iterations.

Originality/value
This paper proposes a new RSM technology based on proxy model to complete the reliability design. The originality of this paper is to increase the sampling points by identifying the local importance of the analysis domain and introduce the constrained ESA to improve the efficiency of the algorithm.
The impact of exposure to missionaries on the English language proficiency and earnings of immigrants in the USA
Authors: Larsen Nicholas , Chiswick Barry R. 
Published: March 2019

Purpose
The purpose of this paper is to explore how potential exposure to missionary activity impacts both English language proficiency and labor market earnings of male and female immigrants to the USA.

Design/methodology/approach
This study uses the pooled files of the American Community Survey (2005–2009). To estimate the relationship between the missionary activity of both Protestants and Catholics on an immigrant’s English language proficiency using a linear probability model and their labor market earnings using the human capital earnings function that is estimated with an ordinary least squares model. Among other relevant variables, the analysis controls for the colonial heritage of the immigrant’s country of origin.

Findings
Overall, and within colonial heritages, the results indicate that male and female immigrants from countries with a higher concentration of Protestant missionaries tend to exhibit higher levels of English language proficiency and earnings, and those from countries with a greater concentration of Catholic missionaries exhibit lower levels of both, compared to countries with lower concentrations of missionaries. Furthermore, a greater proficiency in English enhances earnings. One of the important implications of the findings in this paper is that a “missionary variable” often used in other studies is too aggregate and may mask important findings because of strikingly different effects of Protestant and Catholic activities and characteristics of the missionaries.

Originality/value
This study explores for the first time how, through a missionary concentration variable, potential exposure to missionary activity impacts the English language proficiency and earnings of immigrants.
An exploration into consumers’ e-learning strategies
Authors: Steils Nadia , Decrop Alain , Crié Dominique 
Published: March 2019

Purpose
As traditional paper manuals and step-by-step instructions have shown to discourage new product learning because of a lack of exploration, the purpose of this paper is to investigate consumer learning from an online and andragogical, that is, adult learning, perspective by identifying relevant consumer e-learning processes in new product learning.

Design/methodology/approach
This paper uses thematic and trace analyses on a multi-method data collection, that is, extant e-learning courses, in-depth interviews and non-participant observations.

Findings
Emerging findings give light on customized, interactive and iterative e-learning processes depending on consumers’ previous experiences, their learning orientation as adult learners and the characteristics of the online environment. Results provide evidence for the existence of three learning strategies and show how the online environment comes shifting traditional consumer learning paradigms.

Originality/value
This paper contributes to the literature on consumer behavior on two levels. First, the findings highlight the importance of taking an andragogical standpoint to provide a more nuanced and realistic view on consumers’ learning processes in new product learning. Second, the results show how the exploration and interactivity provided by the online environment present beneficial prerequisites for effective consumer learning. More than just being an alternative, online learning is complementary to offline modes of learning to improve consumers’ overall learning experience.
Shopping streets vs malls: preferences of low-income consumers
Authors: Zanini Marco Tulio , Filardi Fernando , Villaça Fábio , Migueles Carmen , Melo Aline Menezes 
Published: March 2019

PurposeThe purpose of this paper is to identify the attributes of shopping streets and shopping malls that influence the satisfaction and patronage intention of low-income consumers in order to understand the consumers’ preferences when it comes to shopping in these retail agglomerations.Design/methodology/approachThe study is based on quantitative and qualitative research, including in-depth interviews and focus groups with low-income consumers. The research collected data from 396 consumers at 3 retail agglomerations in Rio de Janeiro, Brazil, and used a structured questionnaire to identify 12 attributes as the factors of the agglomerations’ attractiveness.FindingsThe results show that the items “selection” and “value” affect satisfaction and patronage intention at the same intensity in both shopping streets and shopping malls. However, the item “access” proved to be important for shopping malls, and the item “security” proved to be important for shopping streets. The results indicate that shopping streets have a preference for patronage intentions, despite the greater satisfaction generated by shopping malls. In addition, the study looked at consumers’ opinions on these retail agglomerations.Originality/valueThe research findings help to build a conceptual framework on evolved retail agglomerations in comparison to created retail agglomeration, represented by shopping streets and shopping malls, respectively. The findings allow a broader view of low-income consumption, offering insights so entrepreneurs and companies can direct their efforts to better capture value and improve the supply of products and services. Likewise, these findings will help public policy decision-makers to build and provide infrastructure for the preservation of shopping streets, maintaining this option for the consumer.
The recovery-oriented therapeutic community for addictions (ROTC): a response to contemporary substance use disorder treatments in the Philippines
Authors: Ramos Sixtus Dane Asuncion 
Published: March 2019

Purpose
The Philippines’ nationwide campaign on drugs has been under the limelight due to its controversial approaches in dealing with the problem of addiction. Despite the government’s current efforts, substance use disorders continue to persist within the population. The purpose of this paper is to provide recommendations for addressing the issue of substance use disorder treatment through a modification of the therapeutic community (TC) in the Philippine context.

Design/methodology/approach
This conceptual paper reviews the existing facts about the Philippines’ campaign against drugs, the approaches implemented by the government, current state and research developments of TCs, and its resulting impact on contemporary evidence-based treatment for addiction in the country.

Findings
A treatment framework outlining a recovery-oriented therapeutic community (ROTC) is presented. The ROTC aims to address addiction as a chronic, relapsing disease. This alternative approach for addiction treatment in the Philippines is based on the concept of recovery, principles of effective substance use disorder treatment, and recent developments in TC best practices from the international community.

Originality/value
This paper discusses different recommendations for policy development, interventions and research, aimed at improving the odds of securing recovery for people suffering from addiction.
Selfhood and ‘Nostalgia’: Sensory and Material Memories of the Childhood Home in Late Georgian Britain
Authors: Begiato Joanne 
Published: March 2019

AbstractFocusing on autobiographies written from the 1790s to the 1820s, this article demonstrates that material, emotional and sensory memories of the childhood house and its location were integral to constructions of self. First, it traces the interplay between prevailing cultural forms, family memory and identity, and proposes that these changed over time, shaped by cultural, social and economic factors. Second, in analysing these personal memories, it contributes to the debates around the meanings of the ‘emotional disposition’ of nostalgia, arguing that it was central to the formation of both national culture and individual selfhood.
Editorial: shining a light on cholangiocarcinoma—a new dawn for photodynamic therapy? Authors’ reply
Authors: Gonzalez‐Carmona Maria A. , Bolch Maximilian , Strassburg Christian P. , Weismüller Tobias J. 
Published: March 2019

Linked ContentThis article is linked to Gonzalez‐Carmona et al and Srinivasa and
Wigmore papers. To view these articles, visit https://doi.org/10.1111/apt.15050 and https://doi.org/10.1111/apt.15093.
Letter: non‐alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density—authors’ reply
Authors: Targher Giovanni , Mantovani Alessandro , Dauriz Marco , Bonnet Fabrice , Byrne Christopher D. 
Published: March 2019

Linked ContentThis article is linked to Mantovani et al and Yarandi papers. To view
these articles, visit https://doi.org/10.1111/apt.15087 and https://doi.org/10.1111/apt.15170.
Editorial: blood transfusion for lower gastrointestinal bleeding—authors’ reply
Authors: Kherad Omar , Jairath Vipul 
Published: March 2019

Linked ContentThis article is linked to Kherad et al and Taha papers. To view these
articles, visit https://doi.org/10.1111/apt.15158 and https://doi.org/10.1111/apt.15172.
Step‐by‐step technique for single‐port robot‐assisted radical cystectomy and pelvic lymph nodes dissection using the da Vinci® SP™ surgical system
Authors: Kaouk Jihad , Garisto Juan , Eltemamy Mohamed , Bertolo Riccardo 
Published: March 2019

ObjectivesTo describe a step‐by‐step technique for robot‐assisted radical cystectomy (RARC) with pelvic lymph node dissection (PLND) performed using the da Vinci® SP™ surgical system (Intuitive Surgical Inc., Sunnyvale, CA, USA).Patients and MethodsFour consecutive patients diagnosed with urothelial carcinoma of the bladder were counselled for RARC with PLND and ileal conduit urinary diversion performed using the da Vinci SP surgical system. A 3‐cm midline incision was made 5‐cm above the umbilicus. Dissection was performed to access the abdominal cavity. Insertion of the GelPOINT® advanced access platform (Applied Medical, Rancho Santa Margarita, CA, USA) with the SP Cannula was performed through the incision made. A 12‐mm AirSeal® (SurgiQuest Inc., Milfort, CT, USA) port for the assistant was placed on the pre‐marked stoma site, where an ileal conduit urinary diversion was desired. Demographics and perioperative outcomes were collected under Institutional Review Board approval (IRB 13‐780). The surgeries were performed by reproducing the steps of the institutional approach for RARC performed with the multi‐arm robotic platform.ResultsThe surgeries were successfully completed. There was neither conversion to standard multi‐arm robotic or open approaches nor the need for additional port placement. The mean (range) operative time was 454 (420–496) min. Blood loss averaged 312 mL. No transfusions were required and no intraoperative complications occurred. All patients had negative surgical margins. All patients were discharged on postoperative day 5.ConclusionFrom our preliminary experience, RARC with PLND and ileal conduit urinary diversion is feasible and safe using the da Vinci SP surgical system. Further comparative studies with open and multi‐arm robotic approaches are warranted.
Sensing between reactions – how the metabolic microenvironment shapes immunity
Authors: Lötscher J , Balmer M L 
Published: March 2019

SummaryPerception of potential threat is key for survival. The immune system constantly patrols the organism scanning for potential pathogenic or malignant danger. Recent evidence suggests that immunosurveillance not only relies on classic receptors [e.g. Toll-like receptors (TLRs) or antibodies] but is also based on sensing of the metabolic environment. Metabolites interact in numerous ways with immune cells, and are therefore more than just reaction intermediates. This new perspective opens the door for potential, future therapeutic strategies. Here we describe how immune functionality during infections, cancer or autoimmunity, as exemplified by short-chain fatty acids, lactate and reactive oxygen species (ROS), can be shaped by metabolic intermediates.
Nummular Headache: 2 Cases With Good Beta Blocker Responses and a Narrative Review
Authors: Jiang Li , Li Maolin , Liu Qing , Liu Chaoyang , Zhou Jiying 
Published: March 2019

ObjectiveTo report 2 new nummular headache (NH) cases and review the clinical features and management of NH.BackgroundNH is a coin‐shaped headache with a fixed shape and size. Since the first case series was reported by Pareja, approximately 300 cases have been reported. However, the latest treatment status and pathogenesis of NH remain unclear.MethodsTwo new NH cases with improved symptomatic responses to metoprolol were reported. We also conducted a narrative review of cases published in English aiming to provide the newest information about the clinical features and management of NH.ResultsTwo NH patients with skin depressions within the painful area experienced significantly improvement with metoprolol. The literature review showed that NH was mainly moderate‐to‐severe in 77.8% (186/239) of the patients. Sensory dysfunction and focal trophic changes were reported in 47.8% (149/312) and 3.8% (12/312) of the patients, respectively. Gabapentin was the most commonly used and effective prophylactic, with a responder rate of 67.9% (55/81). Botulinum toxin type A was used for refractory NH, with an effective rate of 81.8% (9/11). Ten patients from the previous studies were prescribed β‐adrenergic blockers without any relief, and none of them reported focal tropic changes.ConclusionsNH can be a disabling headache in more than half of identified patients and requires medical intervention. As with the previous treatment recommendations, gabapentin was the most commonly used prophylactic with a good response. Our cases suggested that β‐adrenergic blockers could be a therapeutic option for NH patients with focal trophic changes within the areas.
Familial Hemiplegic Migraines and Baseline Neuropsychological Testing: A Case Report
Authors: Trahan Elizabeth M. , Mercado Janyna M. 
Published: March 2019

ObjectiveTo explore the neuropsychological correlates and implications of familial hemiplegic migraines (FHMs).BackgroundFMH is a rare, autosomal dominant subtype of migraine that only occurs in 0.01% of the population. Little is known about the neuropsychological impact of FHMs; however, cognitive impairment associated with cerebellar syndrome has been identified in some cases.MethodA single case study involving a 24‐year‐old male who recently endured an atypical, prolonged FHM episode.ResultsThe patient’s overall neuropsychological functioning was intact with low average semantic fluency and processing speed, and mild indications of executive dysfunction.ConclusionBaseline and serial neuropsychological testing in individuals with FHM may help identify the potential progression and course of cognitive impairment associated with this condition.
A Method for Detecting Regression of Hard and Easy Item Angoff Ratings
Authors: Wyse Adam E. , Babcock Ben 
Published: March 2019

AbstractOne common phenomenon in Angoff standard setting is that panelists regress their ratings in toward the middle of the probability scale. This study describes two indices based on taking ratios of standard deviations that can be utilized with a scatterplot of item ratings versus expected probabilities of success to identify whether ratings are regressed in toward the middle of the probability scale. Results from a simulation study show that the standard deviation ratio indices can successfully detect ratings for hard and easy items that are regressed in toward the middle of the probability scale in Angoff standard‐setting data, where previously proposed indices often do not work as well to detect these effects. Results from a real data set show that, while virtually all raters improve from Round 1 to Round 2 as measured by previously developed indices, the standard deviation ratios in conjunction with a scatterplot of item ratings versus expected probabilities of success can identify individuals who may still be regressing their ratings in toward the middle of the probability scale even after receiving feedback. The authors suggest using the scatterplot along with the standard deviation ratio indices and other statistics for measuring the quality of Angoff standard‐setting data.
An Item‐Level Expected Classification Accuracy and Its Applications in Cognitive Diagnostic Assessment
Authors: Wang Wenyi , Song Lihong , Chen Ping , Ding Shuliang 
Published: March 2019

AbstractMost of the existing classification accuracy indices of attribute patterns lose effectiveness when the response data is absent in diagnostic testing. To handle this issue, this article proposes new indices to predict the correct classification rate of a diagnostic test before administering the test under the deterministic noise input “and” gate (DINA) model. The new indices include an item‐level expected classification accuracy (ECA) for attributes and a test‐level ECA for attributes and attribute patterns, and both of them are calculated based solely on the known item parameters and Q‐matrix. Theoretical analysis showed that the item‐level ECA could be regarded as a measure of correct classification rates of attributes contributed by an item. This article also illustrates how to apply the item‐level ECA for attributes to estimate the correct classification rate of attributes patterns at the test level. Simulation results showed that two test‐level ECA indices, ECA_I_W (an index based on the independence assumption and the weighted sum of the item‐level ECAs) and ECA_C_M (an index based on Gaussian Copula function that incorporates the dependence structure of the events of attribute classification and the simple average of the item‐level ECAs), could make an accurate prediction for correct classification rates of attribute patterns.
Efficiency of Targeted Multistage Calibration Designs Under Practical Constraints: A Simulation Study
Authors: Berger Stéphanie , Verschoor Angela J. , Eggen Theo J. H. M. , Moser Urs 
Published: March 2019

AbstractCalibration of an item bank for computer adaptive testing requires substantial resources. In this study, we investigated whether the efficiency of calibration under the Rasch model could be enhanced by improving the match between item difficulty and student ability. We introduced targeted multistage calibration designs, a design type that considers ability‐related background variables and performance for assigning students to suitable items. Furthermore, we investigated whether uncertainty about item difficulty could impair the assembling of efficient designs. The results indicated that targeted multistage calibration designs were more efficient than ordinary targeted designs under optimal conditions. Limited knowledge about item difficulty reduced the efficiency of one of the two investigated targeted multistage calibration designs, whereas targeted designs were more robust.