bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 4-Yr Survey of the Range of Ticks and Tick-Borne Pathogens in the Lehigh Valley Region of Eastern Pennsylvania
Authors: Edwards Marten J , Russell James C , Davidson Emily N , Yanushefski Thomas J , Fleischman Bess L , Heist Rachel O , Leep-Lazar Julia G , Stuppi Samantha L , Esposito Rita A , Suppan Louise M 
Published: April 2019

AbstractQuesting ticks were surveyed by dragging in forested habitats within the Lehigh Valley region of eastern Pennsylvania for four consecutive summers (2015–2018). A high level of inter-annual variation was found in the density of blacklegged tick nymphs, Ixodes scapularis Say, with a high density of host-seeking nymphs (DON) in summer 2015 and 2017 and a relatively low DON in summer 2016 and 2018. Very few American dog ticks (Dermacentor variabilis Say) and Ixodes cookei Packard were collected. Lone star ticks (Amblyomma americanum L.) and longhorned ticks (Haemaphysalis longicornis Neumann) were not represented among the 6,398 ticks collected. For tick-borne pathogen surveillance, DNA samples from 1,721 I. scapularis nymphs were prepared from specimens collected in summers 2015–2017 and screened using qPCR, high resolution melting analysis, and DNA sequencing when necessary. The overall 3-yr nymphal infection prevalence of Borrelia burgdorferi was 24.8%, Borrelia miyamotoi was 0.3%, Anaplasma phagocytophilum variant-ha was 0.8%, and Babesia microti was 2.8%. Prevalence of coinfection with B. burgdorferi and B. microti as well as B. burgdorferi and A. phagocytophilum variant-ha were significantly higher than would be expected by independent infection. B. burgdorferi nymphal infection prevalence is similar to what other studies have found in the Hudson Valley region of New York, but levels of B. microti and A. phagocytophilum variant-ha nymphal infection prevalence are relatively lower. This study reinforces the urgent need for continued tick and pathogen surveillance in the Lehigh Valley region.
Association Between Neutralizing Antibody Titers against Parechovirus A3 in Maternal and Cord Blood Pairs and Perinatal Factors
Authors: Shimizu Hiromi , Hashimoto Koichi , Sato Maki , Sato Akiko , Sato Masatoki , Maeda Hajime , Kyozuka Hyo , Kawasaki Yukihiko , Yokoyama Tadahiko , Fujimori Keiya , Yasumura Seiji , Hosoya Mitsuaki 
Published: April 2019

AbstractBackgroundParechovirus A3 (PeV-A3) is a pathogen that causes severe infectious diseases such as sepsis and meningoencephalitis in neonates and young infants. In this study, we aimed to measure the neutralizing antibody titer (NAT) against PeV-A3 in paired maternal and cord blood samples and to clarify the serum epidemiology of PeV-A3 and the association between the NAT and perinatal factors.MethodsNATs against PeV-A3 were measured in 1033 mothers (maternal and cord blood pairs; total of 2066 samples) who delivered their infant in Fukushima Prefecture between December 2013 and June 2014. RD-18S cells were used to measure NATs against PeV-A3. The association between NATs against PeV-A3 in maternal and cord blood and perinatal factors was determined using multivariate logistic regression analysis.ResultsThe median gestational age of the infants was 39 weeks 4 days (interquartile range, 38 weeks 4 days to 40 weeks 3 days). The NATs against PeV-A3 in maternal blood and in cord blood were almost the same. The proportion of samples assigned to the low-titer group (NAT ≤ 1:16) was approximately 70%, and the proportion of samples assigned to the high-titer group tended to increase with gestational age. The high-titer rate and geometric mean titers decreased with increased maternal age.ConclusionsCord blood indicates that neonates born at a lower gestational age and older mothers have a low NAT against PeV-A3. Thus, more attention should be paid to the onset of severe PeV-A3 disease in such neonates and young infants.
Degree of electric current neutralization and the activity in solar active regions
Authors: Vemareddy P 
Published: April 2019

Abstract
Using time-sequence vector magnetic field observation from Helioseismic and Magnetic Imager, we examined the connection of non-neutralized currents and the observed activity in 20 solar active regions (ARs). The net current in a given magnetic polarity is algebraic sum of direct current (DC) and return current (RC) and the ratio |DC/RC| is a measure of degree of net current neutralization (NCN). In the emerging ARs, the non-neutrality of these currents builds with the onset of flux emergence, following the relaxation to neutrality during the separation motion of bipolar regions. Accordingly, some emerging ARs are source regions of CMEs occurring at the time of higher level non-neutrality. ARs in the post-emergence phase can be CME productive provided they have interacting bipolar regions with converging and shearing motions. In these cases, the net current evolves with higher level (&gt;1.3) of non-neutrality. Differently, the |DC/RC| in flaring and quiet ARs vary near unity. In all the AR samples, the |DC/RC| is higher for chiral current density than that for vertical current density. Owing to the fact that the non-neutralized currents arise in the vicinity of sheared polarity-inversion-lines (SPILs), the profiles of the total length of SPIL segments and the degree of NCN follow each other with a positive correlation. We find that the SPIL is localized as small segments in flaring-ARs, whereas it is long continuous in CME-producing ARs. These observations demonstrate the dividing line between the CMEs and flares with the difference being in global or local nature of magnetic shear in the AR that reflected in non-neutralized currents.
G5.89: an explosive outflow powered by a proto-stellar merger?
Authors: Zapata Luis A , Ho Paul T P , Guzmán Ccolque Estrella , Fernández-Lopéz Manuel , Rodríguez Luis F , Bally John , Sanhueza Patricio , Palau Aina , Saito Masao 
Published: April 2019

ABSTRACTThe explosive outflows are a newly discovered family of molecular outflows associated with high-mass star-forming regions. Such energetic events are possibly powered by the release of gravitational energy related with the formation of a (proto)stellar merger or a close stellar binary. Here, we present sensitive and high angular resolution observations (0.85 arcsec) archival CO(J = 3–2) observations carried out with the Submillimeter Array of the high-mass star-forming region G5.89−0.39 that reveal the possible presence of an explosive outflow. We find six well-defined and narrow straight filament-like ejections pointing back approximately to the centre of an expanding molecular and ionized shell located at the centre of this region. These high-velocity (−120 to +100 km s−1) filaments follow a Hubble-like velocity law with the radial velocities increasing with the projected distance. The estimated kinematical age of the filaments is about of 1000 yr, a value similar to the dynamical age found for the expanding ionized shell. G5.89 is the thus the third explosive outflow reported in the galaxy (together with Orion BN-KL and DR21) and argues in favour of the idea that this is a frequent phenomenon. In particular, explosive outflows, in conjunction with runaway stars, demonstrate that dynamical interactions in such groups are very important ingredients in star formation.
Outcomes After Repeat Transsphenoidal Surgery for Recurrent Cushing Disease: Updated
Authors: Burke William T , Penn David L , Repetti Caroline S , Iuliano Sherry , Laws Edward R 
Published: April 2019

Abstract

BACKGROUND
Transspheniodal surgery (TSS) for Cushing disease (CD) is considered the first-line treatment; however, reported recurrence rates are high.

OBJECTIVE
To systemically review indications and outcomes for repeat TSS in recurrent CD.

METHODS
Retrospective review of patients undergoing TSS from 2008 to 2018 was performed. Patients undergoing repeat TSS for clinical and/or biochemically recurrent CD with follow-up at least 12 mo postoperatively were included. These data were analyzed in our “current cohort” and combined with our previously published data in a “combined cohort.”

RESULTS
The current cohort of patients undergoing operations from 2008 to 2018 with repeat surgery following a prior operation included 15 patients. Pathology at the time of first operation was positive for adrenocortiotrophic hormone (ACTH) adenoma in 13/15 (86.7%) and 9/15 (60%) had evidence of recurrence after a previous surgical procedure on preoperative magnetic resonance imaging (MRI). Remission was achieved immediately postoperatively in 13/15 (86.7%). Over an average follow-up of 34.7 mo (range: 12-116), 11/15 (68.8%) achieved persistent remission. When combined with the historical cohort that underwent an operation during 1992−2006, 44/51 (86.3%) patients had a prior operation demonstrating ACTH adenoma and 35/51 (68.6%) had evidence of recurrent disease on preoperative MRI. Thirty-five (68.6%) patients went into remission immediately postoperatively. Thirty one (60.8%) had continued remission at most recent reported follow-up.

CONCLUSION
Recurrent CD can be a therapeutic challenge; however, these data demonstrate that in many patients repeat surgery can be an effective and safe next step prior to radiation or medical therapy.
Electrical (Pain) Thresholds and Conditioned Pain Modulation in Patients with Low Back–Related Leg Pain and Patients with Failed Back Surgery Syndrome: A Cross-Sectional Pilot Study
Authors: Goudman Lisa , Huysmans Eva , Coppieters Iris , Ickmans Kelly , Nijs Jo , Buyl Ronald , Putman Koen , Moens Maarten 
Published: April 2019

Abstract

Objective
When evaluating sensory dysfunctions and pain mechanisms in patients with low back pain (LBP), a specific subgroup of patients with radicular symptoms is often excluded. Comparative studies that evaluate sensory sensitivity in patients with a dominant nociceptive and neuropathic pain component are rarely performed. Therefore, the goal of this study was to examine differences in electrical thresholds and conditioned pain modulation (CPM) between patients with low back–related leg pain (LBRLP) and patients with failed back surgery syndrome (FBSS).

Design
Cross-sectional study.

Setting
University Hospital Brussels.

Subjects
Twenty-one patients with LBRLP and 21 patients with FBSS were included.

Methods
Electrical detection thresholds (EDTs), electrical pain thresholds (EPTs), and CPM were evaluated on the symptomatic and nonsymptomatic sides. Within- and between-group differences were evaluated for all parameters.

Results
No between-group differences were found for EDT and EPT at both sides. On the nonsymptomatic side, a significantly lower CPM effect was found in the FBSS group (P = 0.04). The only significant within-group difference was an increased EDT at the symptomatic side in patients with FBSS (P = 0.01).

Conclusions
LBP patients with a primary neuropathic pain component revealed altered detection sensitivity at the symptomatic side, without severe indications for altered nociceptive processing, compared with LBP patients without a dominant neuropathic pain component. Endogenous modulation is functioning in LBP patients, although it is possible that it might only be functioning partially in patients with a dominant neuropathic pain component.
A Virtual Reality Intervention for the Treatment of Phantom Limb Pain: Development and Feasibility Results
Authors: Rutledge Thomas , Velez Deborah , Depp Colin , McQuaid John R , Wong Garland , Jones R Carter W , Atkinson J Hampton , Giap Bosco , Quan Alex , Giap Huan 
Published: April 2019

Abstract

Objective
To describe the development of a virtual reality (VR) treatment for phantom limb pain (PLP) and phantom sensations and provide feasibility data from testing the treatment in a population of veterans.

Design & Subjects
Fourteen participants completed a baseline visit evaluating their amputation, PLP, and phantom sensations. Subsequently, participants completed a VR treatment modeled after mirror therapy for PLP, navigating in a VR environment with a bicycle pedaler and motion sensor to pair their cadence to a VR avatar. The VR avatar enabled visualization of the participant’s intact phantom limb in motion, a hypothesized mechanism of mirror therapy.

Setting
Laboratory.

Methods
Participants completed pre- and post-treatment measures to evaluate changes in PLP, phantom sensations, and rate helpfulness, realism, immersion, adverse experiences, and treatment satisfaction.

Results
Eight of 14 participants (57.1%) reported PLP pre–VR treatment, and 93% (13/14) reported one or more unpleasant phantom sensations. After treatment, 28.6% (4/14) continued to report PLP symptoms (t[13] = 2.7, P = 0.02, d = 0.53) and 28.6% (4/14) reported phantom sensations (t[13] = 4.4, P = 0.001, d = 1.7). Ratings of helpfulness, realism, immersion, and satisfaction were uniformly high to very high. There were no adverse experiences. Four participants completed multiple VR treatments, showing stable improvements in PLP intensity and phantom sensations and high user ratings.

Conclusions
This feasibility study of a novel VR intervention for PLP was practical and was associated with significant reductions in PLP intensity and phantom sensations. Our findings support continued research in VR-based treatments in PLP, with a need for direct comparisons between VR and more established PLP treatments.
Pre-emotional Awareness and the Content-Priority View
Authors: Mitchell Jonathan 
Published: April 2019

AbstractMuch contemporary philosophy of emotion has been in broad agreement about the claim that emotional experiences have evaluative content. This paper assesses a relatively neglected alternative, which I call the content-priority view, according to which emotions are responses to a form of pre-emotional value awareness, as what we are aware of in having certain non-emotional evaluative states which are temporally prior to emotion. I argue that the central motivations of the view require a personal level conscious state of pre-emotional value awareness. However, consideration of extant suggestions for the relevant type of evaluative state shows them all to be problematic. As such, I conclude that at present we do not have a persuasive formulation of the content-priority view, and that to get one defenders of the view need to specify which version they are committed to and defend it against the criticisms raised.
Injectable mechanical pillows for attenuation of load-induced post-traumatic osteoarthritis
Authors: Holyoak Derek T , Wheeler Tibra A , van der Meulen Marjolein C H , Singh Ankur 
Published: April 2019

AbstractOsteoarthritis (OA) of the knee joint is a degenerative disease initiated by mechanical stress that affects millions of individuals. The disease manifests as joint damage and synovial inflammation. Post-traumatic osteoarthritis (PTOA) is a specific form of OA caused by mechanical trauma to the joint. The progression of PTOA is prevented by immediate post-injury therapeutic intervention. Intra-articular injection of anti-inflammatory therapeutics (e.g. corticosteroids) is a common treatment option for OA before end-stage surgical intervention. However, the efficacy of intra-articular injection is limited due to poor drug retention time in the joint space and the variable efficacy of corticosteroids. Here, we endeavored to characterize a four-arm maleimide-functionalized polyethylene glycol (PEG-4MAL) hydrogel system as a ‘mechanical pillow’ to cushion the load-bearing joint, withstand repetitive loading and improve the efficacy of intra-articular injections of nanoparticles containing dexamethasone, an anti-inflammatory agent. PEG-4MAL hydrogels maintained their mechanical properties after physiologically relevant cyclic compression and released therapeutic payload in an on-demand manner under in vitro inflammatory conditions. Importantly, the on-demand hydrogels did not release nanoparticles under repetitive mechanical loading as experienced by daily walking. Although dexamethasone had minimal protective effects on OA-like pathology in our studies, the PEG-4MAL hydrogel functioned as a mechanical pillow to protect the knee joint from cartilage degradation and inhibit osteophyte formation in an in vivo load-induced OA mouse model.
Accelerated mineralization on nanofibers via non-thermal atmospheric plasma assisted glutamic acid templated peptide conjugation
Authors: Onak Günnur , Karaman Ozan 
Published: April 2019

Abstract
Surface modification by non-thermal atmospheric plasma (NTAP) treatment can produce significantly higher carboxylic groups on the nanofibers (NF) surface, which potentially can increase biomineralization of NF via promoting glutamic acid (GLU) templated peptide conjugation. Herein, electrospun poly(lactide-co-glycolide) (PLGA) scaffolds were treated with NTAP and conjugated with GLU peptide followed by incubation in simulated body fluids for mineralization. The effect of NTAP treatment and GLU peptide conjugation on mineralization, surface wettability and roughness were investigated. The results showed that NTAP treatment significantly increased GLU peptide conjugation which consequently enhanced mineralization and mechanical properties of NTAP treated and peptide conjugated NF (GLU-pNF) compared to neat PLGA NF, NTAP treated NF (pNF) and GLU peptide conjugated NF (GLU-NF). The effect of surface modification on human bone marrow derived mesenchymal stem cells adhesion, proliferation and morphology was evaluated by cell proliferation assay and fluorescent microscopy. Results demonstrated that cellular adhesion and proliferation were significantly higher on GLU-pNF compared to NF, pNF and GLU-NF. In summary, NTAP treatment could be a promising modification technique to induce biomimetic peptide conjugation and biomineralization for bone tissue engineering applications.
The Fragile Brain: Stress Vulnerability, Negative Affect and GABAergic Neurocircuits in Psychosis
Authors: Taylor Stephan F , Grove Tyler B , Ellingrod Vicki L , Tso Ivy F 
Published: April 2019

AbstractPersons with schizophrenia exhibit sensitivity to stress and negative affect (NA), both strongly correlated with poor functional outcome. This theoretical review suggests that NA reflects a “fragile brain,” ie, vulnerable to stress, including events not experienced as stressful by healthy individuals. Based on postmortem evidence of altered gamma-aminobutyric acid (GABA) function in parvalbumin positive interneurons (PVI), animal models of PVI abnormalities and neuroimaging data with GABAergic challenge, it is suggested that GABAergic disruptions weaken cortical regions, which leads to stress vulnerability and excessive NA. Neurocircuits that respond to stressful and salient environmental stimuli, such as the hypothalamic-pituitary-adrenal axis and the amygdala, are highly dysregulated in schizophrenia, exhibiting hypo- and hyper-activity. PVI abnormalities in lateral prefrontal cortex and hippocampus have been hypothesized to affect cognitive function and positive symptoms, respectively; in the medial frontal cortex (dorsal anterior cingulate cortex and dorsal medial prefrontal cortex), these abnormalities may lead to vulnerability to stress, NA and dysregulation of stress responsive systems. Given that postmortem PVI disruptions have been identified in other conditions, such as bipolar disorder and autism, stress vulnerability may reflect a transdiagnostic dimension of psychopathology.
Spatiotemporal palaeodiversity patterns of modern crocodiles (Crocodyliformes: Eusuchia)
Authors: De Celis Ane , Narváez Iván , Ortega Francisco 
Published: April 2019

AbstractEusuchia is a crocodyliform clade with a rich and diverse fossil record dating back to the Mesozoic. There are several recent studies that analyse crocodyliform palaeodiversity over time, but none of them focuses exclusively on eusuchians. Thus, we estimated subsampled eusuchian palaeodiversity species dynamics over time not only at a global scale, but also by continents and main crocodylian lineages (Alligatoroidea, Crocodyloidea and Gavialoidea). These estimates reveal complex spatiotemporal palaeodiversity patterns, in which two maxima can be detected: the first during the Palaeocene and the second, which is also the biggest, in the middle-late Miocene. The Palaeocene shift is related to a North American alligatoroid diversification, whereas the middle–late Miocene maximum is related to a diversification of the three main Crocodylia lineages in Gondwanan land masses, but especially in South America. Additionally, a model-based study using generalized least squares was carried out to analyse the relationships between different abiotic and sampling proxies and eusuchian palaeodiversity. The results show that palaeotemperature is the most important factor amongst the analysed proxies, in accordance with previous studies. However, the results suggest that, along with palaeotemperature, other abiotic and/or biotic factors might also be driving eusuchian palaeodiversity dynamics.
Internal friction can be measured with the Jarzynski equality
Authors: Kailasham R. , Chakrabarti Rajarshi , Prakash J. Ravi 
Published: April 2019

AbstractA simple protocol for the extraction of the internal friction coefficient of polymers is presented. The proposed scheme necessitates repeatedly stretching the polymer molecule, and measuring the average work dissipated in the process by applying the Jarzynski equality. The internal friction coefficient is then estimated from the average dissipated work in the hypothetical limit of zero solvent viscosity. The validity of the protocol is established through Brownian dynamics simulations of a single-mode spring-dashpot model for a polymer. Well-established single-molecule manipulation techniques, such as optical tweezer-based pulling, can be used to implement the suggested protocol experimentally.