bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-Fel d1 immunoglobulin Y antibody-containing egg ingredient lowers allergen levels in cat saliva
Authors: Satyaraj Ebenezer , Li Qinghong , Sun Peichuan , Sherrill Scott 
Published: July 2019

Objectives Fel d1 is the major cat allergen, causing IgE reactions in up to 90% of cat-allergic adults. Fel d1 secreted in saliva is spread to the haircoat during grooming. Current management includes attempts to reduce or eliminate exposure to Fel d1. A novel approach to reducing immunologically active Fel d1 (aFel d1) exposure, which involves binding the Fel d1 with an anti-Fel d1-specific polyclonal egg IgY antibody (sIgY), was evaluated. The hypothesis was that saliva from cats fed diets containing this sIgY would show a significant reduction in aFel d1. Methods Two trials in cats were completed. In trial 1, saliva was collected 0, 1, 3 and 5 h post-feeding during a 2 week baseline and subsequent 6 week treatment period. Trial 2 included a control and treatment group, and saliva was collected once daily. Trial 2 cats were fed the control diet during a 1 week baseline period, and then fed either control or sIgY diet during the 4 week treatment period. Fel d1-specific ELISA was used to measure salivary aFel d1. Data were analysed using repeated-measures ANOVA and a linear mixed-model analysis. Results Salivary aFel d1 decreased post-treatment in both trials. There were no differences in aFel d1 based on time of collection relative to feeding in trial 1. In trial 2, 82% of treatment group cats showed a decrease in aFel d1 of at least 20% from baseline vs just 38% of control cats. Only one (9%) treatment cat showed an increase in aFel d1 vs 63% of control cats. Conclusions and relevance Feeding sIgY significantly reduced aFel d1 in the saliva of cats within 3 weeks. Although additional research is needed, these findings show promise for an alternative approach to the management of allergies to cats.
Ability of people with post-stroke hemiplegia to self-administer FES-assisted hand therapy video games at home: An exploratory case series
Authors: Fu Michael J , Harley Mary Y , Hisel Terri , Busch Robyn , Wilson Richard , Chae John , Knutson Jayme S 
Published: July 2019

Introduction This article describes the development and initial clinical testing of an innovative home-based treatment for upper extremity hemiplegia that integrates contralaterally controlled functional electrical stimulation with hand therapy video games. Methods We explored the ability of seven participants with moderate-to-severe hand impairment to self-administer 12 weeks of contralaterally controlled functional electrical stimulation video game therapy at home for 10 h/week and in-lab with a therapist for four h/week. Clinical suitability was assessed by device usage logs, qualitative surveys, and clinical motor and cognitive outcomes. Results Three participants completed the study with > 95% compliance and four did not. Factors linked to incompletion included development of trigger finger in the non-paretic hand, acceptance of a new full-time job, residence relocation, and persistence of drowsiness from anti-spasticity medication. Those who completed the treatment perceived qualitative benefits and experienced gains in motor and cognitive outcomes. Conclusion Individuals with moderate-to-severe chronic post-stroke upper extremity hemiplegia can self-administer contralaterally controlled functional electrical stimulation video game therapy for up to 90 min/day at home. We also identified social and physiological factors that may preclude its use for daily home treatment. Further studies are warranted and are in progress to estimate treatment effect and optimal dose of this intervention.
Cost-Effectiveness of Percutaneous Lymphatic Embolization for Management of Plastic Bronchitis
Authors: Benjamin Jamaal L. , Rychik Jack , Johnstone Jordan A. , Nadolski Gregory J. , Itkin Maxim 
Published: July 2019

Background: Plastic bronchitis is a dreaded complication of single ventricle physiology occurring following palliation via Fontan procedure. Medical management of plastic bronchitis often fails, requiring heart transplantation. Percutaneous lymphatic embolization is an emerging treatment for plastic bronchitis. Methods: To determine the cost-effectiveness of competing management strategies, a modified Markov model was constructed with patients transiting through treatments—medical management, lymphatic embolization, or heart transplantation from a hospital system perspective. Health state transitions were modeled using an institutional review board–approved retrospective review of the Children’s Hospital of Pennsylvania’s plastic bronchitis cohort. Medication pricing data were obtained from the National Inpatient Sample. Differences in costs and quality-adjusted life years (QALYs) over a five-year horizon for each group were determined. The incremental cost-effectiveness ratio was then calculated. Results: The mean cost of lymphatic embolization from procedure performance was US$340,941, US$385,841 for heart transplantation, and US$594,520 for medical management. The mean quality-adjusted survival of lymphatic embolization yielded an additional 0.66 QALYs ( P < .03) relative to heart transplantation and 1.3 ( P < .0001) relative to medical management. Orthotopic heart transplantation yielded an additional 0.66 QALYs ( P = .06) when comparing heart transplantation to medical management. Compared to medical management, lymphatic embolization generated an incremental cost-effectiveness ratio of US$192,105. Similarly, compared to heart transplantation, lymphatic embolization yielded an incremental cost-effectiveness ratio of US$68,030. Conclusions: Of the available plastic bronchitis treatments, with a willingness to pay of US$150,000, lymphatic embolization produces an incremental cost-effectiveness ratio within the bounds considered to be cost-effective, potentially causing financial benefits to the health system.
Impact of FDA-Required Cardiovascular Outcome Trials on Type 2 Diabetes Clinical Study Initiation From 2008 to 2017
Authors: Kieffer Cameron M. , Robertson Andrew S. 
Published: July 2019

Background: Since 2008, the US Food and Drug Administration (FDA) has required that drug manufacturers conduct postmarket cardiovascular outcomes trials (CVOTs) for approved type 2 diabetes mellitus (T2DM) drugs. The utility and impact of these studies in determining atherosclerotic cardiovascular risk was reviewed during an FDA Advisory Committee Meeting held on October 24, 2018. Drug manufacturers and patient advocates at this meeting contended that the FDA-required CVOT studies discouraged private sector investment into developing novel T2DM drugs. Here, we explore these contentions by reviewing private sector investment in T2DM drug development from 2000 through 2008, followed by a deductive analysis of how associated events—including the implementation of the CVOT requirement—may have precipitated any observed changes. Methods: We collected and analyzed industry-sponsored interventional trials for T2DM initiated between January 1, 2000, and December 31, 2017, and compared observed trends with those seen across all trials, specific diseases, and against patent filings of novel antidiabetic agents. Results: The analysis shows a marked decline in initiated T2DM clinical trials from 2008 through 2017. Possible influencing factors, including the 2008 financial crisis and a slow in the discovery of novel antidiabetic agents may have contributed, but could not fully account for this decline in T2DM studies. Conclusions: These observations are consistent with the statements made by industry representatives and patient advocates at the 2018 Advisory Committee meeting. As the FDA reconsiders postmarket requirements for T2DM products, these observations underscore the importance of considering more efficient postmarket study structures to assess cardiovascular safety beyond mandatory CVOTs.
Use of Zipper Ratcheting Straps as a Bailout for Postoperative Cerebrospinal Fluid Leaks: Our Experience
Authors: Kulkarni Arvind G. , Tapashetti Sandeep , Patel Priyank M. 
Published: July 2019

Study Design: Technical note. Objectives: Management of postoperative cerebrospinal fluid (CSF) leaks is a challenge. Reexploration increases the morbidity risks. The main objective was to evaluate the outcomes of noninvasive zipper-like system (Zip surgical skin closure system, ZipLine Medical, Inc, Campbell, CA, USA) as a bailout technique for postoperative CSF leaks. Methods: Retrospective case series. Consecutive patients with postoperative CSF leaks that occurred secondary to spinal surgeries performed between January 2017 and September 2018 were part of the study. All these patients were managed conservatively by reinforcement with zipper ratcheting straps over the sutured surgical wound. Successful clinical outcomes included cessation of CSF leaks and adequate wound healing in the postoperative period and at follow-up. Results: Ten patients underwent the application of zipper ratcheting straps. The mean follow-up was 6 months (range 6 months to 1 year). In 7 cases, the dural tears were recognized postoperatively and in 3 cases, the tears were noted intraoperatively and repaired and reinforced with fibrin sealants. None of the patients developed wound soakage or subsequent CSF leak from the wound after the application of zipper ratcheting straps. Conclusions: Zipper ratcheting straps as augmentation to sewing of the wound seem to be a good alternative and bailout in treating patients with postoperative CSF leaks. The ease of its application, the ability in minimizing the complications associated with CSF leaks, and negating the need of surgical reexploration makes it a worthy option.
The effect of comorbid personality disorder on depression outcome after short-term psychotherapy in a randomised clinical trial
Authors: Koppers David , Kool Marit , Van Henricus , Driessen Ellen , Peen Jaap , Dekker Jack 
Published: July 2019

Background
Time-limited psychotherapy for depression is effective. However, comorbid personality disorders affect therapy outcomes negatively. Studies of follow-up effects and results relating to the influence of comorbid personality disorder and treatment modality are scarce.

Aims
To determine the influence of comorbid personality disorder and treatment modality on outcomes after cognitive–behavioural therapy (CBT) or short-term psychodynamic supportive psychotherapy (SPSP) for depression.

Method
This study draws on data from a previously published randomised clinical trial contrasting SPSP and CBT for depression (both 16 sessions). We compared the effectiveness of these psychotherapies for patients with and without personality disorder (n = 196). The primary measure was depression outcome; the secondary measurements were interpersonal functioning and quality of life. Collected data were analysed using multilevel analysis. Trial registration: ISRCTN31263312 (http://www.controlled-trials.com).

Results
Although participants with and without comorbid personality disorder improved at treatment termination (d = 1.04, 95% CI 0.77–1.31 and d = 1.36, 95% CI 0.97–1.76, respectively) and at follow-up (d = 1.15, 95% CI 0.87–1.43 and d = 2.12, 95% CI 1.65–2.59 respectively), personality disorder had a negative effect on depression outcome at both measurement points (P < 0.05). A similar negative effect on interpersonal functioning was no longer apparent at follow-up. Comorbid personality disorder had no influence on social functioning or quality of life outcomes, irrespective of treatment modality.

Conclusions
CBT and SPSP contribute to the improvement of depressive symptoms and interpersonal problems in depressed patients with and without comorbid personality disorder. Both treatments are an effective first step in a stepped care approach, but – given remaining levels of depression in patients with personality disorder – they are probably inadequate for large numbers of patients with this comorbidity.

Declaration of interest
None.
Prevalence and Distribution of Human Papillomavirus Genotypes Among Women in Kinshasa, The Democratic Republic of the Congo
Authors: Mutombo Alex B. , Benoy Ina , Tozin Rahma , Bogers Johannes , Van geertruyden Jean-Pierre , Jacquemyn Yves 
Published: July 2019

PURPOSE Cervical cancer is the leading cause of mortality by cancer in sub-Saharan Africa. The human papillomavirus (HPV) infection is recognized as a necessary and sufficient cause for cervical cancer. Population-specific estimates of HPV prevalence in the Democratic Republic of the Congo (DRC) are unknown. This study aims to estimate the prevalence of HPV and identify predominant genotypes circulating in Kinshasa, DRC. METHODS Between July 2015 and July 2017, women were invited to attend a screening program at Mont-Amba Health Centre in Kinshasa. Cervical specimens were collected using the Preservcyt medium. HPV DNA testing was performed for all specimens using real-time polymerase chain reaction. RESULTS During the 2-year period, a total of 1,870 women age 25 to 82 years were screened. The mean age was 46 years (± 11.4 years). The overall HPV prevalence was 28.2% (95% CI, 26.1% to 30.3%). High-risk HPV prevalence was 24.8% (95% CI, 22.8% to 26.8%). Women younger than 30 years had the highest overall HPV prevalence (42.2%; 95% CI, 34.7% to 49.9%). A second peak of prevalence was observed in women age 60 years and older. HPV68 (5.5%; 95% CI, 4.5% to 6.6%) was the most prevalent HPV type. CONCLUSION The distribution of HPV genotypes among women in our population was different compared with other world regions. A key finding was that HPV68 was the most prevalent high-risk HPV genotype. These findings highlight the need for the determination in our population of the etiologic fraction of different HPV types in invasive cervical cancers.
“You Have to Keep a Roof Over Your Head”: A Qualitative Study of Housing Needs Among Patients With Cancer in New York City
Authors: Phillips Serena , Raskin Sarah E. , Harrington Cherise B. , Brazinskaite Ruta , Gany Francesca M. 
Published: July 2019

PURPOSE: Housing status can become compromised in the wake of financial hardship for some patients with cancer and become a source of disparity. This qualitative study describes the types of housing issues experienced by patients with cancer and survivors of cancer in New York City. METHODS: Semistructured interviews were conducted with a volunteer sample of 21 patients with cancer or survivors of cancer treated in New York City who reported housing needs in the period after diagnosis through survivorship. Nine supplemental interviews were conducted with cancer and housing key informants. Conventional content analysis was conducted on transcripts to create a codebook describing types of housing needs. RESULTS: Patients and survivors most commonly had breast (n = 9) and blood (n = 4) cancers and ranged from recently diagnosed to many years posttreatment. Twenty-nine distinct housing-related issues were identified, which were grouped into the following six major categories: housing costs (eg, rent, mortgage), home loss, doubled up or unstable housing, housing conditions, accessibility (eg, stairs, proximity to amenities), and safety. Issues were often interrelated. Housing needs sometimes predated cancer diagnosis. Other issues newly emerged in the wake of cancer-related physical limitations and disruption to finances. Needs ranged in severity and caused patients and survivors considerable burden during a difficult period of poor health and financial strain. CONCLUSION: This study contributes depth to current understandings of housing needs among patients with cancer and survivors by providing detailed disaggregated descriptions. We recommend increasing availability of services responsive to these needs and exploring promising options such as patient navigation and legal services. Findings also highlight the importance of creative solutions addressing ecologic-level factors such as housing affordability.
Presidential Address: A Rainbow of Spanish Illusions: Research Frontiers in Colonial Guatemala
Authors: Lovell W. George 
Published: July 2019

AbstractCompared still to what we know about Mexico and Peru, the historiography of colonial Guatemala, despite notable advances, continues to lag behind, registering minimally in the Latin American scholarly imagination. The field is surveyed by examining some of the issues that have intrigued the author over the course of his career. Personal reflections are offered of research activities that engage indigenous resistance to Spanish intrusion, demographic collapse in the wake of conquest, the link between disease outbreaks and Maya demise, and the role played by Pedro de Alvarado (1485–1541) in attaining imperial objectives. Scrutiny of the Lienzo de Quauhquechollan, a sixteenth-century source the contents of which have been incisively reappraised, affords fuller appreciation of strategic Indian involvement in the act of subjugation. Alvarado, a key protagonist in the conquest of Mexico, also harbored ambitions to muscle in on the conquest of Peru, a little-known episode that awaits further investigation. The conqueror’s own life, like Central America itself, may indeed have been a rainbow of Spanish illusions, pots of gold dreamed of, lost and found at native expense.
The Personal Politics of Action and Applied Anthropology
Authors: Cobb Daniel M. 
Published: July 2019

AbstractAction anthropology came to the fore during the 1950s and 1960s, in part as a critical response to applied anthropology’s colonial and governmental entanglements, seeking to learn from communities by collaboratively pursuing solutions to practical problems. While critical assessments of theory, method, and efficacy abound, the everyday human bonds fostered through these approaches seldom receive mention. This essay focuses on the personal and intellectual relationships Robert K. Thomas and Murray L. Wax formed with Ponca activist Clyde Warrior via the Workshop on American Indian Affairs, Carnegie Corporation Cross-Cultural Education Project, and Kansas Indian Education Research Project during the 1960s. It illuminates some of the interior dimensions of these two expressions of public-facing engaged scholarship.1
How ‘smart’ is smart dentistry?
Authors: Kokol Peter , Blažun Vošner Helena , Završnik Jernej , Turčin Marko 
Published: July 2019

Background:Latest advances in information and health technologies enabled dentistry to follow the paradigm shift occurring in medicine – the transition to so called smart medicine. Consequently, the aim of this paper is to assess how ‘smart’ is smart dentistry as of the end of 2018.Methods:We analysed the state of the art in smart dentistry, performing bibliometric mapping on a corpus of smart dentistry papers found in the Scopus bibliographical database.Results:The search resulted in a corpus of 3451 papers, revealing that smart dentistry research is following the progress in smart medicine; however, there are some gaps in some specific areas like gamification and use of holistic smart dentistry systems.Conclusions:Smart dentistry is smart; however, it must become smarter.
Methods of conduct and reporting of living systematic reviews: a protocol for a living methodological survey
Authors: Khamis Assem M. , Kahale Lara A. , Pardo-Hernandez Hector , Schünemann Holger J. , Akl Elie A. 
Published: July 2019

Background: The living systematic review (LSR) is an emerging approach for improved evidence synthesis that uses continual updating to include relevant new evidence as soon as it is published. The objectives of this study are to: 1) assess the methods of conduct and reporting of living systematic reviews using a living study approach; and 2) describe the life cycle of living systematic reviews, i.e., describe the changes over time to their methods and findings. Methods: For objective 1, we will begin by conducting a cross-sectional survey and then update its findings every 6 months by including newly published LSRs. For objective 2, we will conduct a prospective longitudinal follow-up of the cohort of included LSRs. To identify LSRs, we will continually search the following electronic databases: Medline, EMBASE and the Cochrane library. We will also contact groups conducting LSRs to identify eligible studies that we might have missed. We will follow the standard systematic review methodology for study selection and data abstraction. For each LSR update, we will abstract information on the following: 1) general characteristics, 2) systematic review methodology, 3) living approach methodology, 4) results, and 5) editorial and publication processes. We will update the findings of both the surveys and the longitudinal follow-up of included LSRs every 6 months. In addition, we will identify articles addressing LSR methods to be included in an ‘LSR methods repository’. Conclusion: The proposed living methodological survey will allow us to monitor how the methods of conduct, and reporting as well as the findings of LSRs change over time. Ultimately this should help with ensuring the quality and transparency of LSRs.
KEDUDUKAN PARA PIHAK DALAM PERJANJIAN KERJASAMA OPERASIONAL PENGEMBANGAN LAHAN PERUMAHAN DAN IMPLIKASINYA TERHADAPHAK PENGELOLAAN LAHAN
Authors: Sawitri Galuh 
Published: July 2019

Abstract The unity of PT Pradipta Ratnapratala as the owner of the asset with PT Citra Mitra Properti (Ciputra Group) as investor in the Land Development Cooperation Agreement gave birth to a new business entity entity by the parties named "Citra Pradipta KSO".. The formulation of issues that can be stated is the legal standing of the parties in the Cooperation of Cooperation Agreement / KSO of Land Development, how the implications of the legal status of the parties to the right of land management and whether efforts can be made to the rights and obligations of the parties in the operational cooperation agreement to be balanced and equivalent. The research used empirical juridical approach method with qualitative data analysis. The result of this research is the position of the parties in the Cooperation Agreement of Land Development Cooperation, namely PT Pradipta Ratnapratala as the holder of the land of cooperation / as the owner of the asset tends to passive, which then affects the loss of PT Pradipta Ratnapratala's right as the owner of the rightful owner or the right land of cooperation land, to be involved in the implementation process of housing project development. Efforts that can be made is to improve and / or add clauses in the agreement and include the owner of the asset in the operational activities of land development, although in practice the authority will be given with certain limitations.. Abstrak Bersatunya PT Pradipta Ratnapratala selaku pemilik asset dengan PT Citra Mitra Properti (Ciputra Grup) selaku investor dalam Perjanjian Kerjasama Pengembangan Lahan melahirkan sebuah entitas pelaku usaha baru yang oleh para pihak diberi nama “Citra Pradipta KSO”.Rumusan masalah yang dapat dikemukakan adalah kedudukan hukum para pihak dalam Perjanjian Kerjasama Operasional/ KSO Pengembangan Lahan, bagaimana implikasi dari kedudukan hukum para pihak tersebut terhadap hak pengelolaan lahan serta apakah upaya yang dapat dilakukan agar hak dan kewajiban para pihak dalam perjanjian kerjasama operasional menjadi seimbang dan setara. Penelitian menggunakan metode pendekatan yuridis empiris dengan analisa data kualitatif.Hasil penelitian ini adalah kedudukan para pihak dalam Perjanjian Kerjasama Operasional Pengembangan Lahan yaitu pihak PT Pradipta Ratnapratala selaku pemegang hak atas tanah lahan kerjasama/selaku pemilik asset cendrung pasif, yang kemudian berdampak pada hilangnya hak PT Pradipta Ratnapratala selaku pemilik asset atau pemegang hak yang sah terhadap tanah lahan kerjasama, untuk ikut terlibat pada proses pelaksanaan pembangunan proyek perumahan. Upaya yang dapat dilakukan adalah memperbaiki dan/atau menambahkan klausul-klausul dalam perjanjiandan mengikut sertakan pihak pemilik asset dalam kegiatan operasional pengembangan lahan, walaupun dalam pelaksanaannya kewenangan tersebut akan diberikan dengan batasan tertentu.