bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pricing models of two-sided markets incorporating service quality
Authors: Xue Zhaojie , Cheng Shuqing , Yu Mingzhu , Zou Liang 
Published: December 2018

Purpose
This paper aims to study the pricing problems on the two-sided market for cases of monopoly and duopoly competition, specifically investigating the impact of platform service quality on the market. Theoretical analysis and computational studies are conducted to investigate the impact of different parameters on the system outcomes.

Design/methodology/approach
Mathematical formulations are proposed for cases of monopoly and duopoly competition. For monopolistic market, the optimal pricing and service quality strategies are obtained using mathematical programming method. For duopolistic market, the equilibrium outcomes are derived by game theory. Sensitivity analysis and numerical studies are also adopted to investigate the impact of different parameters.

Findings
For monopolistic market, the platform will provide a low service quality when the service cost parameter is large. However, when the cost parameter is small, the platform provides a higher service quality and higher registration prices. Furthermore, the sum of the optimal prices is proportional to the service quality and inversely proportional to the user price sensitivity. For duopolistic market, the competitive equilibrium prices exist under a certain condition. The determinants of equilibrium prices are the gap between the service qualities of two platforms and the cross-group externalities.

Originality/value
For monopolistic market, this paper specifies the role of platform service quality in determining the platform’s pricing strategy. For duopolistic market, this paper presents a market sharing mechanism between two platforms and explores the equilibrium pricing strategies for platforms with different service quality level.
The moderating effect of blogger social influence and the reader’s experience on loyalty toward the blogger
Authors: Urrutikoetxea Arrieta Beñat , Polo Peña Ana Isabel , Martínez Medina Cinta 
Published: December 2018

PurposeThe purpose of this paper is to analyze the moderating effects of the social influence of the blogger and the extent to which the reader has experience of that blogger, on loyalty toward the blogger, via two variables: blogger interactive practices (BIPs) and blogger credibility.Design/methodology/approachA quantitative empirical study was undertaken to estimate the research model. Structural equations were employed.FindingsThe results show that blogger social influence moderates the relationships between BIPs and intention to recommend the blogger and blogger credibility; and between credibility and intention (to recommend the blogger and to follow their suggestions). Meanwhile, the extent of the reader’s experience of the blogger moderates the relationships between BIPs and intention.Practical implicationsThe present work offers criteria that may be of value to bloggers and firms in assessing the extent to which the blogger’s activities are effective in terms of achieving reader loyalty. The proposed variables are measured objectively online, using the Klout Index of social influence and the extent of the reader’s experience of the blogger (inferred from the number of bloggers followed by the reader).Originality/valueBlogs are considered a mechanism to manage information overload in social media, and they are recognized for their influence on the reader’s decision-making process. The study contributes to the knowledge-base by proposing two moderating variables of loyalty-formation: blogger social influence and the extent of the reader’s experience of the blogger.
The impacts of evaluation duration and product types on review extremity
Authors: Zhu Huawei , Tu Rungting , Feng Wenting , Xu Jiaojiao 
Published: December 2018

Purpose
Extreme online reviews can have great impacts on consumers’ purchase decisions. The purpose of this paper is to investigate when users are more likely to provide extreme ratings. The study draws inference from attitude certainty theory and proposes that review extremity is influenced by the interaction of evaluation duration and product/service types: for hedonic products/services, shorter evaluation duration can foster attitude certainty, leading to higher review extremity; in contrast, for utilitarian products/services, longer evaluation duration can increase attitude certainty, resulting in more extreme reviews.

Design/methodology/approach
Three studies were conducted to test the hypotheses: Study 1 is an empirical analysis of 3,000 reviews from an online retailing website; Studies 2 and 3 are two between-subject experiments.

Findings
Results from three studies confirm the hypotheses. Study 1 provides preliminary evidence on how review extremity varies in evaluations of different durations and product/service types. Results from Studies 2 and 3 show that for hedonic products/services, the shorter the evaluation duration, the more likely users are to give extreme ratings; however, for utilitarian products/service, the longer the evaluation duration, the more likely users are to give extreme reviews; and attitude certainty plays a mediating role between evaluation duration and review extremity.

Originality/value
Findings from this study provide understandings on when a fast rather than a slow evaluation can lead to more extreme reviews. The results also highlight the role of users’ attitude certainty in the underlying mechanism.
Case of pityriasis rubra pilaris progressed to generalized erythroderma following blockade of interleukin‐17A, but improved after blockade of interleukin‐12/23 p40
Authors: Matsuda Tomoko , Yamazaki Fumikazu , Ueda‐Hayakawa Ikuko , Kambe Naotomo , Okamoto Hiroyuki 
Published: December 2018

AbstractWe report herein a case of a 72‐year‐old man with pityriasis rubra pilaris (PRP) that was refractory to conventional therapies. His skin lesions progressed to generalized erythroderma despite anti‐interleukin (IL)‐17A antibody therapy. Topical corticosteroids, emollients, systemic retinoid, methotrexate, cyclosporin and phototherapy yielded no therapeutic response. However, blockade of IL‐12/23 p40 dramatically improved his cutaneous lesions. Complete remission was achieved 4 weeks after the first injection of ustekinumab and maintained for more than 48 weeks. Our data indicate that IL‐12 was associated with the onset of PRP in this patient, rather than IL‐23. IL‐12 is critical for the differentiation of T‐helper (Th)1 cells. Thus, the Th1 pathway may be associated with the onset of PRP.
A low proportion of rare bacterial taxa responds to abiotic changes compared with dominant taxa
Authors: Kurm Viola , Geisen Stefan , Gera Hol Wilhelmina H. 
Published: December 2018

SummaryIn many studies, rare bacterial taxa have been found to increase in response to environmental changes. These changes have been proposed to contribute to the insurance of ecosystem functions. However, it has not been systematically tested if rare taxa are more likely to increase in abundance than dominant taxa. Here, we study whether rare soil bacterial taxa are more likely to respond to environmental disturbances and if rare taxa are more opportunistic than dominant taxa. To test this, we applied nine different disturbance treatments to a grassland soil and observed changes in bacterial community composition over 7 days. While 12% of the dominant taxa changed in abundance, only 1% of the rare taxa showed any effect. Rare taxa increased in response to a single disturbance treatment only, while dominant taxa responded to up to five treatments. We conclude that rare taxa are not more likely to contribute to community dynamics after disturbances than dominant taxa. Nevertheless, as rare taxa outnumber abundant taxa with here 230 taxa that changed significantly, the chance is high that some of these rare taxa might act as ecologically important keystone taxa. Therefore, rare and abundant taxa might both contribute to ecosystem insurance.
Nature Abhors a Vacuum: Highly Diverse Mechanisms Enable Spoilage Fungi to Disperse, Survive, and Propagate in Commercially Processed and Preserved Foods
Authors: Snyder Abigail B. , Biango‐Daniels Megan N. , Hodge Kathie T. , Worobo Randy W. 
Published: December 2018

AbstractFungal spoilage in processed foods remains a challenge for food manufacturers despite the increasing availability of diverse processing and formulation strategies used to control foodborne microorganisms. Physiological features of yeasts and molds contribute to their tolerance to thermal processing, acidity, desiccation, and oxygen and nutrient limitations. These features variably include growth form, cell wall structure, cytoplasmic composition, cell membrane‐bound proteins, and secretion of secondary metabolites. Collectively, these mechanisms contribute to the ability of fungi to disperse, survive, and propagate in highly restrictive food environments. The diversity of fungal growth and survival mechanisms has resulted in organisms adapted to nearly all food environments; although, only a small subset of fungi are particularly suited for spoilage of a given product. The relationship between the individual physiology and metabolic capabilities of a yeast or mold and the product's specific physicochemical attributes and processing history determines spoilage potential. Explicit characterization of the fungal features responsible for this extremotolerance contributes to more targeted and effective control strategies.
Inferring introgression using RADseq and DFOIL: Power and pitfalls revealed in a case study of spiny lizards (Sceloporus)
Authors: Lambert Shea M. , Streicher Jeffrey W. , Fisher‐Reid M. Caitlin , Méndez de la Cruz Fausto R. , Martínez‐Méndez Norberto , García-Vázquez Uri Omar , Nieto Montes de Oca Adrián , Wiens John J. 
Published: December 2018

AbstractIntrogression is now commonly reported in studies across the Tree of Life, aided by recent advancements in data collection and analysis. Nevertheless, researchers working with nonmodel species lacking reference genomes may be stymied by a mismatch between available resources and methodological demands. In this study, we demonstrate a fast and simple approach for inferring introgression using RADseq data, and apply it to a case study involving spiny lizards (Sceloporus) from northeastern México. First, we find evidence for recurrent mtDNA introgression between the two focal species based on patterns of mito‐nuclear discordance. We then test for nuclear introgression by exhaustively applying the “five‐taxon” D‐statistic (DFOIL) to all relevant individuals sampled for RADseq data. In our case, this exhaustive approach (dubbed “ExDFOIL”) entails testing up to ~250,000 unique four‐taxon combinations of individuals across species. To facilitate use of this ExDFOIL approach, we provide scripts for many relevant tasks, including the selection of appropriate four‐taxon combinations, execution of DFOIL tests in parallel and visualization of introgression results in phylogenetic and geographic space. Using ExDFOIL, we find evidence for ancient introgression between the focal species. Furthermore, we reveal geographic variation in patterns of introgression that is consistent with patterns of mito‐nuclear discordance and with recurrent introgression. Overall, our study demonstrates that the combination of DFOIL and RADseq data can effectively detect introgression under a variety of sampling conditions (for individuals, populations and loci). Importantly, we also find evidence that batch‐specific error and linkage in RADseq data may mislead inferences of introgression under certain conditions.
Does news travel slowly before a market crash? The role of margin traders
Authors: Qian Li , Li Mingsheng , Li Yan 
Published: December 2018

AbstractWe investigate how investor overconfidence and attention affect market efficiency around the 2015 Chinese stock market crash. We find that the price delay before the crash is about twice the price delay after the crash. Investors become more sensitive to market movements after the crash. Price delays are larger on market down‐days than on up‐days before the crash, but the differences are insignificant between up‐ and down‐days after the crash, indicating that negative information travels slowly only when investors are overconfident. Margin traders follow market trends and intensify the pyramiding and de‐pyramiding effects caused by market sentiment change.
Burrowing bugs of the genus Scaptocoris Perty in Colombia (Heteroptera: Cydnidae)
Authors: Forero Dimitri , Castro‐Huertas Valentina , Fernández Fernando 
Published: December 2018

AbstractScaptocoris Perty, 1833 (Cephalocteinae) is an economically important genus of burrowing bug because its species attack various crops like pastures, soybean and cotton in South America. The genus Scaptocoris has seven described species in the Neotropical region. Given a confusing history of identifications of its species in Colombia, there is uncertainty about which species occur in the country, hampering the implementation of effective control measures. Therefore, a synopsis of the burrowing bugs of the genus Scaptocoris occurring in Colombia is presented. Three species are recorded from Colombia: Scaptocoris castanea Perty, 1833, a new country record, Scaptocoris divergens Froeschner, 1960, and Scaptocoris minor Berg, 1894, whose identity is confirmed with voucher specimens for the first time. Diagnosis, distribution maps, photographs and plant associations for all three species are presented. The male aedeagus is documented for the first time for Scaptocoris species, although it has no obvious diagnostic characters for them. The importance of voucher specimens for studies in economic entomology is highlighted and discussed.
The effects of switching EGFR‐TKI treatments for non‐small cell lung cancer because of adverse events
Authors: Sakata Yoshihiko , Kawamura Kodai , Shingu Naoki , Hiroshige Shigeo , Yasuda Yuko , Eguchi Yoshitomo , Anan Keisuke , Hisanaga Junpei , Nitawaki Tatsuya , Nakano Aiko , Ichikado Kazuya 
Published: December 2018

AbstractBackgroundEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) are used to treat patients with non‐small cell lung cancer (NSCLC) and EGFR driver mutations. Although some patients discontinued these treatments because of adverse events, it is unclear whether switching EGFR‐TKI because of adverse events provides a benefit.MethodsThis retrospective study evaluated data from 22 patients with EGFR mutation‐positive NSCLC who received at least two EGFR‐TKIs that were switched because of adverse events (March 2011 to September 2017). Progression‐free survival 2 (PFS2) was defined as the time from starting of the first EGFR‐TKI treatment to disease progression during the second EGFR‐TKI treatment.ResultsSeventeen patients received gefitinib as the first EGFR‐TKI treatment, while four patients received afatinib and one patient received erlotinib. The median time to failure of the first EGFR‐TKI treatment was 1.6 months. The EGFR‐TKIs were switched because of hepatotoxicity (n = 16), interstitial lung disease (n = 3), and other reasons (n = 3). The median washout period was 1.1 months. Seventeen patients received erlotinib as the second EGFR‐TKI treatment, while three patients received gefitinib and two patients received afatinib. The median PFS for the second EGFR‐TKI treatment was 15.2 months. The median PFS2 was 17.7 months and the median overall survival was 32.8 months.ConclusionsSwitching EGFR‐TKIs because of adverse events provided a clinical benefit for patients with EGFR mutation‐positive NSCLC. Appropriate judgment regarding switching from one EGFR‐TKI to another may improve the performance status and prognosis of patients with EGFR mutation‐positive NSCLC.
Long non‐coding RNA AFAP1‐AS1 promoting epithelial‐mesenchymal transition of endometriosis is correlated with transcription factor ZEB1
Authors: Lin Dianchao , Huang Qiansheng , Wu Rongfeng , Dai Songjuan , Huang Zhixiong , Ren Lulu , Huang Sijing , Chen Qionghua 
Published: December 2018

ProblemThe role of the long non‐coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1‐AS1) in the etiology of endometriosis is unknown.Method of StudyExpression of epithelial‐mesenchymal transition (EMT) markers was quantified using qRT‐PCR, immunohistochemistry, and Western blotting. The proliferation, migration, and invasion of ectopic endometrial epithelial cells and Ishikawa cells were evaluated by MTT, EdU, wound healing, and transwell assays. Inflammatory cytokine levels were detected by ELISA. Luciferase assays were used to measure activity of the ZEB1 promoter site pGL3‐P886.ResultsAFAP1‐AS1 levels were much higher in ectopic endometrial tissues than that in eutopic tissues. Expression of ZEB1, E‐cadherin, and keratin was obviously higher in eutopic tissues than those in ectopic tissues. In contrast, expression of vimentin and N‐cadherin was significantly lower in eutopic tissue than those in ectopic tissues. After knockdown of AFAP1‐AS1, the morphology of endometrial epithelial cells varied from spindle fiber shaped to polygon epithelioid and proliferation, migration, and invasion were each inhibited. The knockdown of AFAP1‐AS1 significantly inhibited expression from promoter site pGL3‐P886 of the EMT‐related transcription factor ZEB1. The size of subcutaneous tumours in nude mice was significantly reduced after down‐regulation of AFAP1‐AS1 expression.ConclusionHigher expression of AFAP1‐AS1 positively correlated with greater EMT in ectopic endometrium of patients with endometriosis. Knockdown of AFAP1‐AS1 inhibited E2‐induced activity of promoter site pGL3‐P886 of transcription factor ZTB1, suggesting that AFAP1‐AS1 knockdown inhibited growth of endometrial epithelial cells and that pathogenesis may be correlated with EMT.
The metabolic basis of psychosis in bipolar disorder: A positron emission tomography study
Authors: Marotta Giorgio , Delvecchio Giuseppe , Pigoni Alessandro , Mandolini Gianmario , Ciappolino Valentina , Oldani Lucio , Madonna Domenico , Grottaroli Marika , Altamura Alfredo Carlo , Brambilla Paolo 
Published: December 2018

ObjectivesPsychotic symptoms are a common feature in bipolar disorder (BD), especially during manic phases, and are associated with a more severe course of illness. However, not all bipolar subjects experience psychosis during the course of their illness, and this difference often guides assessment and pharmacological treatment. The aim of the present study is to elucidate, for the first time, the FDG uptake dysfunctions associated with psychosis in BD patients with and without a history of past psychotic symptoms, through a positron emission tomography (PET) approach.MethodsFifty BD patients with lifetime psychotic symptoms, 40 BD patients without lifetime psychotic symptoms and 27 healthy controls (HC) were recruited and underwent an 18F‐FDG‐PET session.ResultsCompared to HC, BD subjects shared common FDG uptake deficits in several brain areas, including insula, inferior temporal gyrus and middle occipital gyrus. Moreover, we found that BD patients with a history of past psychotic symptoms had a unique FDG uptake alteration in the right fusiform gyrus compared to both BD patients without lifetime psychotic symptoms and HC (all P < 0.01, cFWE corrected).ConclusionsOverall, our results suggest that FDG uptake alterations in brain regions involved in emotion regulation are a key feature of BD, regardless the presence of past psychosis. Finally, we demonstrated that the FDG uptake reduction in fusiform gyrus is associated with the presence of past psychotic symptoms in BD, ultimately leading towards the idea that the fusiform gyrus might be considered a putative biomarker of psychosis.
Work‐related learning in the transition from higher education to work: The role of the development of self‐efficacy and achievement goals
Authors: Grosemans Ilke , Coertjens Liesje , Kyndt Eva 
Published: December 2018

BackgroundWork‐related learning is particularly important at the start of graduates' careers. Preparing students for work‐related learning is a chief aim of higher education, demonstrating its relevance when investigating the transition to work.AimThis study aimed to investigate the role of personal factors for work‐related learning during the transition from higher education to work. This study took a longitudinal and person‐centred approach by examining differences in work‐related learning between different motivational profiles based on the conjoint development of self‐efficacy and achievement goals.SampleQuestionnaires were administered four times, starting in the beginning of students' final year of higher education until 4 months after graduation (N = 814).MethodsIn order to assess the development of the personal factors, different multi‐indicator latent growth curve models were estimated. Afterwards, a multidimensional latent class growth analysis was used to identify latent profiles of participants with similar growth trajectories. Differences in work‐related learning were investigated by a multivariate analysis of variance.Results and ConclusionsThe results revealed an average increase in self‐efficacy, learning‐goal, and performance‐approach orientation, indicating that the transition to work triggers change in these personal factors. Performance‐avoidance orientation decreased on average. Four distinct motivational profiles were discerned: strongly efficacious and approach‐oriented, moderate efficacious and approach‐oriented, moderate efficacious and learning‐oriented, and undecided profile. Furthermore, differences were found concerning work‐related learning, in which the strongly efficacious and approach‐oriented profile reported more participation in formal and informal learning activities using personal sources, while the undecided profile showed least participation in the latter.
High tumour plasma cell infiltration reflects an important microenvironmental component in classic Hodgkin lymphoma linked to presence of B‐symptoms
Authors: Gholiha Alex R. , Hollander Peter , Hedstrom Gustaf , Sundstrom Christer , Molin Daniel , Smedby Karin E. , Hjalgrim Henrik , Glimelius Ingrid , Amini Rose‐Marie , Enblad Gunilla 
Published: December 2018

SummaryPlasma cells are important prognostic actors in different malignancies. The tumour microenvironmental composition in classic Hodgkin lymphoma (cHL) is a major prognostic key element; however, clinicopathological studies regarding plasma cells in cHL are lacking. The aim of this study was to investigate CD138+ (also termed SDC1+) plasma cell and IgG4 producing (IgG4+) plasma cells infiltration in the microenvironment of cHL. Immunohistochemistry with anti‐CD138 and IgG4 antibodies was performed on diagnostic tumour biopsies from 124 patients with cHL, on tissue micro array (TMA). In 120 cases, CD138+ plasma cell‐infiltration was associated with the presence of B‐symptoms (P = 0·028) and advanced stage, IIB‐IVB (P = 0·009). In multivariate analysis, CD138+ plasma cells correlated with eosinophil infiltration (P = 0·013). The subgroup of IgG4+ plasma cells was analysed in 122 cases and only correlated to CD138+ plasma cells (P = 0·004). Patients with high proportion of tumour infiltrating CD138+ plasma cells (defined as ≥10%), had a more inferior event‐free survival (P = 0·007) and overall survival (P = 0·004) than patients with a low proportion of infiltrating CD138+ plasma cells (<10%), although significance was not maintained in multivariate analysis. In summary, a high proportion of tumour‐associated plasma cells in cHL reflect an important component in the microenvironment of cHL.