bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory outcomes of onasemnogene abeparvovec treatment for spinal muscular atrophy: national real-world cohort study
Authors: Lavie Moran , Rochman Mika , Armoni Domany Keren , Golan Tripto Inbal , Be’er Moria , Besor Omri , Sagi Liora , Aharoni Sharon , Ginsberg Mira , Noyman Iris , Levine Hagit 
Published: December 2024

Abstract
Onasemnogene abeparvovec (OA) is a novel gene replacement therapy for patients with spinal muscular atrophy (SMA). This study provides real-world respiratory data for pediatric SMA patients receiving OA who were assessed before and one year after treatment in a multicenter cohort study conducted from 2019 to 2021. Twenty-five OA-treated SMA patients (23 with type 1 and 2 with type 2; median age at treatment 6.1 months, with a range of 0.36–23 months) were included. Sixteen were treatment-naïve, and nine had received various prior treatments. Two patients died due to respiratory failure during the study period. Of the remaining 23 patients, four were put on non-invasive ventilation (NIV), bringing ventilated patients to a total of ten during the post-treatment year. Three patients required permanent NIV support, while 13 did not require any respiratory support. Ventilation time decreased from 14.3 to 11.1 hours per day, and respiratory hospitalizations decreased by 26% (from 0.76 to 0.57 per life year). Fifteen of the 23 patients maintained full oral nutrition at study closure compared to 20 of the 25 at study initiation. This real-world data analysis demonstrates that OA may improve respiratory outcomes in SMA patients. Importantly, compounding factors, such as age at treatment initiation, treatment combinations, and natural history, may influence the respiratory course, thus highlighting the need for standardized long-term management.

What is Known:
• Respiratory failure is a leading cause of mortality in untreated spinal muscular atrophy type 1 patients.
• Onasemnogene abeparvovec (OA) improves neurological outcomes, but real-world respiratory data are limited.

What is New:
• Our real-world analysis suggests OA may improve respiratory outcomes.
• Age at treatment and treatment combinations may also influence respiratory trajectory.
Upper Airway Sensory Testing in Dysphagia – Implications for Clinical Practice and Future Research Directions
Authors: Regio Norita , Hutton Ruby , Wallace Emma S. 
Published: December 2024

AbstractAdequate upper airway (oral, pharyngeal and laryngeal) sensation is crucial for safe and efficient swallowing and airway protection. Despite its importance, methods of upper airway sensory testing for individuals with dysphagia remain poorly defined. The aim of this study was to summarise and appraise current methods of upper airway sensory testing to inform dysphagia clinical practice and future research directions. A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies that reported a method of upper airway sensory testing in individuals with dysphagia were included. Of the 1187 studies identified and screened, 54 met the inclusion criteria. Four types of upper airway sensory testing were reported: Flexible Endoscopic Evaluation of Swallowing with Sensory Testing (n = 31), Cough Reflex Testing (n = 22), Gag Reflex Testing (n = 5) and Gustatory (taste) Testing (n = 2). Indeterminate “tests of sensory function” (n = 2) were also reported. Variability in methods was evident across studies and reporting was insufficient for reliable replication. This review provides a comprehensive overview of methods of upper airway sensory testing in the dysphagia literature for dysphagia clinicians and researchers. The results indicate a need to develop a valid and reliable upper airway sensory testing protocol for individuals with dysphagia to improve assessment and targeted treatments.
Comparison of outcomes between surgery and chemoradiotherapy after endoscopic resection for pT1a-MM with lymphovascular invasion or pT1b esophageal squamous cell carcinoma: Japanese multicenter propensity score-matched study
Authors: Yamamoto Yoshinobu , Ishihara Ryu , Kawakubo Hirofumi , Nishikawa Michiko , Yamamoto Sachiko , Kadota Tomohiro , Abe Seiichiro , Yoshida Masao , Tanaka Tsutomu , Nagano Hiroaki , Nakanishi Hiroyoshi , Yoshizaki Tetsuya , Waki Kotaro , Takahashi Akiko , Kitagawa Yoshiyasu , Mizuno Kenichi , Kawada Kenro , Kono Yoshiyasu , Katada Chikatoshi , Hashimoto Takashi , Nagami Yasuaki , Yoshio Toshiyuki , Shimokawa Toshio , Nihei Keiji , Koyanagi Kazuo , Kato Ken , Yano Tomonori , Muto Manabu , Kitagawa Yuko 
Published: December 2024

Abstract
Background
Lymphovascular invasion (LVI) or pT1b is noncurative after endoscopic resection (ER) for esophageal squamous cell carcinoma (ESCC), and therefore surgery or chemoradiotherapy (CRT) is recommended. However, there has been debate regarding which treatment has better outcomes and whether individual risks should be considered.

Methods
This was a multicenter, retrospective study conducted at 65 hospitals in Japan. The inclusion criteria were patients with ESCC who underwent ER between January 2006 and December 2015, with pT1a-muscularis mucosa (MM) with LVI or pT1b, with negative vertical margins, cN0M0, and who underwent surgery or CRT. A 1:1 propensity score-matched analysis was performed between two groups. The primary and secondary end points were overall survival (OS) and relapse-free survival (RFS). OS and RFS were also compared between two subgroups: low risk (pT1a-MM with LVI and pT1b without LVI) and high risk (pT1b with LVI) for metastatic recurrence.

Results
Among 472 patients, 160 patients were selected from each group. The OS and RFS did not differ between surgery and CRT groups (hazard ratio, 0.887; P = .635 and hazard ratio, 1.036; P = .876, respectively). Subgroup analysis showed that CRT had a better prognosis in the low-risk group, and conversely, surgery had a better prognosis in the high-risk group. But these were not significant. The high-risk CRT group had a significant worse prognosis than the low-risk CRT group.

Conclusions
In patients with noncurative ER for ESCC, surgery and CRT showed no difference in long-term outcomes. Indications for CRT in the high-risk group need further investigation because of poor prognosis.
Osteolysis after cervical disc arthroplasty with artificial cervical disc
Authors: Silva Tavares Joana Margarida , Jácome Morgado Diogo Maria , Seromenho Santos Nora Alexandra , Lopes Luís Ana Isabel 
Published: December 2024

Abstract

Purpose
Cervical total disc arthroplasty (TDA) is a motion-preserving alternative to anterior cervical discectomy and fusion that has gained popularity among spine surgeons. Although generally effective, TDA has been associated with rare cases of progressive osteolysis, a complication whose natural history and impact on clinical outcomes are not well understood. This case report aims to present a case of progressive osteolysis following cervical TDA with the SpinalKinetics® M6-C Artificial Cervical Disc and to discuss the clinical approach and implications for patient management.

Methods
We reviewed the clinical course of a patient who underwent cervical TDA with the SpinalKinetics® M6-C Artificial Cervical Disc and subsequently developed progressive osteolysis. The patient’s symptoms, diagnostic findings, and treatment progression were documented, with a focus on the timing of symptom onset, imaging, and the therapeutic interventions applied.

Results
The patient demonstrated a delayed onset of symptoms related to osteolysis, which was identified through CT imaging as a progressive complication. The slow progression of osteolysis in this case underscores the need for careful monitoring, as early symptoms may be subtle but can lead to significant clinical implications if unaddressed.

Conclusion
This case highlights the potential for progressive osteolysis as a complication following cervical TDA, emphasizing the importance of ongoing surveillance and increased awareness among spine surgeons. Early identification and monitoring of osteolysis may mitigate the risk of severe outcomes and guide timely intervention.
On efficient 3D object retrieval
Authors: Liu Hao , Wong Raymond Chi-Wing 
Published: December 2024

Abstract
Due to the growth of the 3D technology, digital 3D models represented in the form of point clouds have attracted a lot of attention from both industry and academia. In this paper, due to a variety of applications, we study a fundamental problem called the 3D object retrieval, which is to find a set of 3D point clouds stored in a database that are similar to a given query 3D point cloud. To the best of our knowledge, solving the problem of 3D object retrieval efficiently remains unexplored in the research community. In this paper, we propose a framework called C

$$_2$$

2

O to find the answer efficiently with the help of an index built on the database. In most of our experiments, C

$$_2$$

2

O performs up to 2 orders of magnitude faster than all adapted algorithms in the literature. In particular, when the database size scales up to 100 million points, C

$$_2$$

2

O answers the 3D object retrieval within 10 s but all adapted exact algorithms need more than 1000 s.
Pexidartinib and standard neoadjuvant therapy in the adaptively randomized I-SPY2 trial for early breast cancer
Authors: Rugo Hope S. , Campbell Mike , Yau Christina , Jo Chien A. , Wallace Anne M. , Isaacs Claudine , Boughey Judy C. , Han Hyo S. , Buxton Meredith , Clennell Julia L. , Asare Smita M. , Steeg Katherine , Wilson Amy , Singhrao Ruby , Matthews Jeffrey B. , Perlmutter Jane , Fraser Symmans W. , Hylton Nola M. , DeMichele Angela M. , Yee Douglas , Van’t Veer Laura J. , Berry Donald A. , Esserman Laura J. 
Published: December 2024

Abstract

Purpose
We investigated the small-molecule receptor tyrosine kinase-inhibitor of colony-stimulating factor-1 receptor pexidartinib in the stage II/III breast cancer in the I-SPY2 platform trial.

Methods
I-SPY2 is an adaptive platform trial that features multiple arms of experimental agents administered on a background of standard neoadjuvant therapy with paclitaxel and adriamycin/cyclophosphamide, followed by definitive surgery. The adaptive randomization engine preferentially assigns patients based upon cumulative performance of each agent in a given breast cancer subtype based on hormone receptor and HER2 receptor status. The study endpoint is pathologic complete response.

Results
A total of 9 participants were randomized to receive pexidartinib with neoadjuvant paclitaxel before enrollment was halted due to a serious adverse event of vanishing bile duct syndrome. No participants received a full course of the study drug.

Conclusion
Although there remains interest in agents targeting CSF-1, hepatic toxicity appears to be a limiting factor for their use in early breast cancer.

Trial registration
NCT01042379 (www.clinicaltrials.gov/ct2/show/NCT01042379).
Improving the performance properties of plastic-sand bricks with Kaolin Clay
Authors: Gounden Kimendren , Mwangi Festus Maina , Mohan Turup Pandurangan , Kanny Krishnan 
Published: December 2024

AbstractThis study analyses the performance properties of plastic-sand bricks through experimental work on the use of High-Density Polyethylene (HDPE) and river sand in the first stage using six different sand: plastic ratios (60s:40p; 65s:35p; 70s:30p; 75s:25p; 80s:20p; 85s:15p) and in the second stage the effects of adding 1%, 5%, and 10% of Kaolin Clay. Five different tests were conducted to assess the bricks’ resistance to environmental factors. The key findings indicate that the lowest water absorption rate of 0.39% was achieved with a 60s:40p ratio, attributed to the addition of 10% Kaolin Clay. Scanning Electron Microscopy (SEM) analysis revealed that Kaolin Clay effectively fills voids between particles, enhancing the structural integrity and reducing water absorption of the brick samples. Electrical resistance readings indicated that all plastic-sand brick samples had a resistance of 0.01 ohms, classifying the composite material as an insulator. Contact angle tests demonstrated that all brick samples resisted immediate water absorption, and no alkali deposits were detected. The lowest linear burning rate was observed in the 75s:25p ratio with a 10% addition of Kaolin Clay. Overall, the findings suggest that HDPE plastic waste can be repurposed to produce eco-friendly plastic-sand bricks, significantly mitigating environmental plastic waste. These composite materials show promise for use as bricks, pavers, and other non-load-bearing applications in the construction industry, providing a sustainable alternative to traditional building materials. This research highlights the potential for HDPE based plastic-sand bricks to contribute to a more sustainable construction sector.
Phase-Dependent Thermoluminescence Properties of Zinc Sulphide
Authors: Farouk Shrouk , Farouk Amany , El-Faramawy Nabil , Elewa Nancy N. 
Published: December 2024

AbstractIn the current study, the effects of heat treatment on the thermoluminescence (TL) and structural properties of zinc blend samples were studied. The samples were annealed after being heated for different time periods from 2 up to 10 h. The wurtzite hexagonal phase was observed upon heat treatment. It was observed that the presence of hexagonal phase with small percentage enhanced the thermoluminescence effect where the highest intensity was found to be for the sample with 8.2% wurtzite and 91.8% cubic zinc sulphide. The morphology of ZnS particles was studied by the HR-TEM analysis and it displayed an aggregated ZnS nanoparticles with almost uniform shape and size. The TL-glow curves for each sample were analysed using the Computerized Glow Curve Deconvolution (CGCD) and initial rise (IR) methods. Six trapping peaks exist between 0.98 and 1.45 eV through the deconvolution process. The number of peaks increased to 8 peaks for the fourth treatment, located between 0.95 and 1.56 eV. The activation energies and the frequency factors for getting traps were evaluated too.
Tools for assessing recreational fisheries compliance—an underappreciated yet essential component of management
Authors: Bova C. S. , Potts W. M. , Radford Z. , Schiefer P. , Hyder K. 
Published: December 2024

Abstract
Despite extensive research on the importance and impacts of recreational fisheries, there is a shortage of information on regulatory compliance in the sector. While recreational fishing has economic and social benefits, the risks to ecosystem health and resource sharing are exacerbated by non-compliance with regulations. This manuscript explores the methodologies employed for assessing non-compliance in recreational fisheries and provide recommendations on best practices for understanding non-compliance. Using EBSCOhost database searches with keywords pertaining to recreational fisheries compliance, a total of 558 studies were reviewed. Of these, only 49 studies specifically examined compliance in recreational fisheries. A broad range of methods have been used to assess compliance, including surveys, observations, law enforcement records analysis, netnography, self-reporting, modelling, and forensic investigations. Of these methods, compliance surveys, although costly, are suitable for estimating various facets of non-compliance and provide the most detailed data. While other methods, such as law enforcement records, netnography and indirect observation, are more cost-effective, they are limited to detecting the presence of some types of non-compliance and should be used initially to determine if non-compliance may exist in a fishery. Understanding the dynamics of compliance is essential for formulating effective management strategies, which aim to mitigate the adverse impacts of recreational fishing on ecosystems while maximising its socio-economic advantages. It is advisable for individuals interested in comprehending compliance within a specific recreational fishery first to employ methodologies capable of ascertaining the existence of non-compliance. Subsequently, they should implement methods to gather more detailed information on compliance, including the extent and underlying factors contributing to non-compliance, through surveys utilising indirect questioning techniques. Ultimately, this study advocates for enhanced efforts from researchers in recreational fisheries to assess non-compliance, as it poses a significant threat to the sustainability of the fishery.
Atomically Precise Cu Nanoclusters: Recent Advances, Challenges, and Perspectives in Synthesis and Catalytic Applications
Authors: Chen Mengyao , Guo Chengyu , Qin Lubing , Wang Lei , Qiao Liang , Chi Kebin , Tang Zhenghua 
Published: December 2024

AbstractAtomically precise metal nanoclusters are an emerging type of nanomaterial which has diverse interfacial metal–ligand coordination motifs that can significantly affect their physicochemical properties and functionalities. Among that, Cu nanoclusters have been gaining continuous increasing research attentions, thanks to the low cost, diversified structures, and superior catalytic performance for various reactions. In this review, we first summarize the recent progress regarding the synthetic methods of atomically precise Cu nanoclusters and the coordination modes between Cu and several typical ligands and then discuss the catalytic applications of these Cu nanoclusters with some explicit examples to explain the atomical-level structure–performance relationship. Finally, the current challenges and future research perspectives with some critical thoughts are elaborated. We hope this review can not only provide a whole picture of the current advances regarding the synthesis and catalytic applications of atomically precise Cu nanoclusters, but also points out some future research visions in this rapidly booming field.
Revealing the Role of Hydrogen in Highly Efficient Ag-Substituted CZTSSe Photovoltaic Devices: Photoelectric Properties Modulation and Defect Passivation
Authors: Zhao Xiaoyue , Li Jingru , Hu Chenyang , Qi Yafang , Zhou Zhengji , Kou Dongxing , Zhou Wenhui , Yuan Shengjie , Wu Sixin 
Published: December 2024

AbstractThe presence of SnZn-related defects in Cu2ZnSn(S,Se)4 (CZTSSe) absorber results in large irreversible energy loss and extra irreversible electron–hole non-radiative recombination, thus hindering the efficiency enhancement of CZTSSe devices. Although the incorporation of Ag in CZTSSe can effectively suppress the SnZn-related defects and significantly improve the resulting cell performance, an excellent efficiency has not been achieved to date primarily owing to the poor electrical-conductivity and the low carrier density of the CZTSSe film induced by Ag substitution. Herein, this study exquisitely devises an Ag/H co-doping strategy in CZTSSe absorber via Ag substitution programs followed by hydrogen-plasma treatment procedure to suppress SnZn defects for achieving efficient CZTSSe devices. In-depth investigation results demonstrate that the incorporation of H in Ag-based CZTSSe absorber is expected to improve the poor electrical-conductivity and the low carrier density caused by Ag substitution. Importantly, the C=O and O–H functional groups induced by hydrogen incorporation, serving as an electron donor, can interact with under-coordinated cations in CZTSSe material, effectively passivating the SnZn-related defects. Consequently, the incorporation of an appropriate amount of Ag/H in CZTSSe mitigates carrier non-radiative recombination, prolongs minority carrier lifetime, and thus yields a champion efficiency of 14.74%, showing its promising application in kesterite-based CZTSSe devices.
Hierarchical Polyimide Nonwoven Fabric with Ultralow-Reflectivity Electromagnetic Interference Shielding and High-Temperature Resistant Infrared Stealth Performance
Authors: Tang Xinwei , Lu Yezi , Li Shuangshuang , Zhu Mingyang , Wang Zixuan , Li Yan , Hu Zaiyin , Zheng Penglun , Wang Zicheng , Liu Tianxi 
Published: December 2024

AbstractDesigning and fabricating a compatible low-reflectivity electromagnetic interference (EMI) shielding/high-temperature resistant infrared stealth material possesses a critical significance in the field of military. Hence, a hierarchical polyimide (PI) nonwoven fabric is fabricated by alkali treatment, in-situ growth of magnetic particles and "self-activated" electroless Ag plating process. Especially, the hierarchical impedance matching can be constructed by systematically assembling Fe3O4/Ag-loaded PI nonwoven fabric (PFA) and pure Ag-coated PI nonwoven fabric (PA), endowing it with an ultralow-reflectivity EMI shielding performance. In addition, thermal insulation of fluffy three-dimensional (3D) space structure in PFA and low infrared emissivity of PA originated from Ag plating bring an excellent infrared stealth performance. More importantly, the strong bonding interaction between Fe3O4, Ag, and PI fiber improves thermal stability in EMI shielding and high-temperature resistant infrared stealth performance. Such excellent comprehensive performance makes it promising for military tents to protect internal equipment from electromagnetic interference stemmed from adjacent equipment and/or enemy, and inhibit external infrared detection.
Quality inspection and error correction of fork-ear type wing-fuselage docking assembly based on multi-camera stereo vision
Authors: Zhu Y.G. , Li D. , Wan Y. , Wang Y.F. , Bai Z.Z. , Cui W. 
Published: December 2024

Abstract
During the automatic docking assembly of aircraft wing-fuselage, using monocular camera or dual-camera to monitor the docking stage of the fork-ear will result in an incomplete identification of the fork-ear pose-position and an inaccurate description of the deviation in the intersection holes’ position coordinates. To address this, a quality inspection and error correction method is proposed for the fork-ear docking assembly based on multi-camera stereo vision. Initially, a multi-camera stereo vision detection system is established to inspect the quality of fork-ear docking assembly. Subsequently, a spatial position solution mathematical model of the fork-ear feature points is developed, and a spatial pose determination mathematical model of fork-ear is established by utilised the elliptical cone. Finally, an enhanced artificial fish swarm particle filter algorithm is proposed to track and estimate the coordinate of the fork-ear feature points. An adaptive weighted fusion algorithm is employed to fuse the detection data from the multi-camera and the laser tracker, and a wing pose-position fine-tuning error correction model is constructed. Experimental results demonstrate that the method enhances the effect of the assembly quality inspection and effectively improves the wing-fuselage docking assembly accuracy of the fork-ear type aircraft.