bluuebunny/crossref_metadata_2025_split huggingface dataset:
International Publication Trends in Proteasome Inhibitors: From Tools for Cell Biologists to Anticancer Agents
Authors: Zhou Peng , Zhu Minhui , Zhang Caiyun , Chen Donghui , Zheng Hongliang 
Published: March 2019

Background:There has been increased interest in the research of proteasome inhibitors for more than two decades. Hotspots in this field are constantly changing.Objective:This study aimed to investigate trends in proteasome inhibitors research from 1992 to 2018 and compare the contributions of such research from different countries and authors.Methods:We used Excel 2013 and VoSviewer to analyze bibliometric data on the subject of proteasome inhibitors, including the number of publications, citations frequency, H-index, and country contributions and hotspots (keywords of popular scientific fields).Results:A total of 3646 articles were included. The USA contributed the largest percentage of articles (1742), with the most citations (90666) and the highest H-index (139). The journal Blood had the most articles. Dana Farber Cancer Institute and Millennium Pharmaceuticals Incorporation were the most contributive institutions. Keywords could be divided into three clusters: Basic experiment, clinical research, and others.Conclusion:The number of proteasome inhibitors articles has been increasing for the past 27 years. The USA made the largest contribution in this field. Recent studies on the topic of “carfilzomib” are relatively new and should be closely followed in proteasome inhibitors research.
Caregiver Daily Reporting of Symptoms in Autism Spectrum Disorder: Observational Study Using Web and Mobile Apps (Preprint)
Authors: Bangerter Abigail , Manyakov Nikolay V. , Lewin David , Boice Matthew , Skalkin Andrew , Jagannatha Shyla , Chatterjee Meenakshi , Dawson Geraldine , Goodwin Matthew S , Hendren Robert , Leventhal Bennett , Shic Frederick , Ness Seth , Pandina Gahan 
Published: March 2019

BACKGROUND

Currently, no medications are approved to treat core symptoms of autism spectrum disorder (ASD). One barrier to ASD medication development is the lack of validated outcome measures able to detect symptom change. Current ASD interventions are often evaluated using retrospective caregiver reports that describe general clinical presentation but often require recall of specific behaviors weeks after they occur, potentially reducing accuracy of the ratings. My JAKE, a mobile and Web-based mobile health (mHealth) app that is part of the Janssen Autism Knowledge Engine—a dynamically updated clinical research system—was designed to help caregivers of individuals with ASD to continuously log symptoms, record treatments, and track progress, to mitigate difficulties associated with retrospective reporting.

OBJECTIVE

My JAKE was deployed in an exploratory, noninterventional clinical trial to evaluate its utility and acceptability to monitor clinical outcomes in ASD. Hypotheses regarding relationships among daily tracking of symptoms, behavior, and retrospective caregiver reports were tested.

METHODS

Caregivers of individuals with ASD aged 6 years to adults (N=144) used the My JAKE app to make daily reports on their child’s sleep quality, affect, and other self-selected specific behaviors across the 8- to 10-week observational study. The results were compared with commonly used paper-and-pencil scales acquired over a concurrent period at regular 4-week intervals.

RESULTS

Caregiver reporting of behaviors in real time was successfully captured by My JAKE. On average, caregivers made reports 2-3 days per week across the study period. Caregivers were positive about their use of the system, with over 50% indicating that they would like to use My JAKE to track behavior outside of a clinical trial. More positive average daily reporting of overall type of day was correlated with 4 weekly reports of lower caregiver burden made at 4-week intervals (r=–0.27, P=.006, n=88) and with ASD symptoms (r=–0.42, P<.001, n=112).

CONCLUSIONS

My JAKE reporting aligned with retrospective Web-based or paper-and-pencil scales. Use of mHealth apps, such as My JAKE, has the potential to increase the validity and accuracy of caregiver-reported outcomes and could be a useful way of identifying early changes in response to intervention. Such systems may also assist caregivers in tracking symptoms and behavior outside of a clinical trial, help with personalized goal setting, and monitoring of progress, which could collectively improve understanding of and quality of life for individuals with ASD and their families.

CLINICALTRIAL

ClinicalTrials.gov NCT02668991; https://clinicaltrials.gov/ct2/show/NCT02668991
Management Dakwah Mosque in Eradicate Use Drugs Problem in Adolescent
Authors: Aziz Abdul 
Published: March 2019

The mosque is a building or an environment surrounded by a fence, especially built for the worship of God Almighty and most commendable. The mosque will function and will be very meaningful if there is proper management and good. Mainly using management science, and one of them is religious propaganda management. It is one of the Islamization of education all because it is a kenyatan that education and development as a process of intensive, to make someone to be able to optimize the physical and non physical aspects.
Purpose writing this is to describe the management of the mosque and its application to ensure that drug abuse does not occur in the younger generation. Today, this problem becomes a reality in cities and villages almost become a culture, as we all know that genersi youth as part of the religion, country and product of the nation if it was not in physical condition is good and fit will take them on social action, crime such as theft, drug abuse. One solution is the mosque's activities. Based on these problems, the authors really want to know the role of propaganda bagimana done to address the drug problem in the younger generation.
Writing is supported by literature and field research. And the authors get the data through observation, interviews and documentation. Then analyze the data from a reduction, to see the data and conclusions. While the subject of research is the mosque of Abu Bakr As-Sidiqdesa Grujugan Kemranjen districts Banyumas in Central Java province of Indonesia.
Based on the results there are: (1) Masjid Abu Bakar As-Sidiq using good management on the physical plane and function. (2) Management of religious proselytizing by DKM and Ikrima to ensure to prevent drug abuse in rural districts Grujugan Kemranjen Banyumas regency, Central Java Province using religious activities such as youth activities in the field of sports, the call of young people or youth build character.
SUPERVISI AKADEMIK MELALUI PENDEKATAN KOLABORATIF OLEH KEPALA SEKOLAH DALAM MENINGKATKAN KUALITAS PEMBELAJARAN GURU DI SD KABUPATEN GROBOGAN
Authors: Dwikurnaningsih Yari 
Published: March 2019

ABSTRACT

This research aimed to increase the quality of instruction through academic supervision with collaborative approached done by school principlas at SD Negeri Kabupaten Grobogan. This research is a school action research. Kemmis and Taggart model is used in this action research model and it was done in two cycles. In each cycle there are planning, implementation and observation and reflection.
There are 10 people who were the subject of the research consist of 1 school principal and 9 teachers of SD Negeri Kabupaten Grobogan. The result of the research shows that the quality of instruction score from cycle I and II had increased. In cycle I the average score is 67,5 and in cycle II it became 90. Steps of academic supervision with collaborative approach includes (1) planning-defining supervision goal, schedule, technique chosen and instruments used; (2) implementation after socaliazation and agreement with teacher, the implementation included examining the learning instruments, observing the learning prosess, doing the assessment of learning; (3) the analysis of supervision result was done by identify the strength and weaknesses of teacher and then drown a concussion. Based on the research result and discussion, it can be concluded that academic supervision done by school principla could increase the quality of teachers’ instruction.

Key words: academic supervision, collaborative approach, quality of instruction.
Nar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi
Authors: DEMİR Tuğba , AKPINAR Özlem , KARA Haki , GÜNGÖR Hüseyin 
Published: March 2019

Bu çalışmada nar (Punica granatum L.) kabuğunun sağlık
açısından önemli antioksidan, antimikrobiyal, antidiyabetik, antienflamatuar ve
sitotoksik özellikleri araştırılmıştır. Nar kabukları (%33 etanol
konsantrasyonu, 78°C, 113 dakika) ekstrakte edilerek fenolik
bileşiklerinin kompozisyonu belirlenmiş, yüksek oranda punigalajin, kafeik asit ve epikateşin içerdiği ve
yüksek antioksidan kapasiteye sahip olduğu tespit edilmiştir. Elde edilen
ekstrakt aynı zamanda, seçilen mikroorganizmalara (Staphylococcus aureus, Enterococcus
faecalis, Escherichia
coli, Aspergillus flavus ve Aspergillus niger) karşı antimikrobiyal
etki göstermiş ve en fazla mikrobiyal direnci S. aureus’a
(21 mm; 1.87 mg ekstrakt/mL) karşı olduğu bulunmuştur. Ekstrakt α-amilaz ve α-glukozidaz
enzimlerini inhibe etmiş ve antidiyabetik özellik göstermiştir. Aynı zamanda
ekstraktın enflamasyondan sorumlu ksantin oksidaz ve lipoksigenaz enzimlerini
de inhibe edebildiği ve meme ve kemik kanseri
hücreleri üzerinde sitotoksik aktiviteye sahip olduğu da gözlenmiştir. Nar
kabuğu ekstraktının belirlenen biyolojik aktiviteleri ile gıda ve gıda dışı
uygulamalarda kullanılabileceği sonucuna varılmıştır.
Civilizational and Mental Discourses of the Russian Theatre as an Identity Code
Authors: Zlotnikova Tatiana S. 
Published: March 2019

The Russian theatre of the last centuries is a distinctly formed identity code, possessing certain content (social and moral) and formal (artistic and aesthe­tic, including those genre and verbal) features. The purpose of this article is to justify the presence of the Russian theater as an identity code, of which we believe there are two discourses — civilizational and mental.Drama is defined as a borderline civilizational code of the Russian theatre. This is both a kind of literature that has developed dynamically, paradoxically, creating an outstanding repertoire for the theater, and the definition of a life situation that characteri­zes theatricality as a specific feature of Russian identity. The civilizational discourse of the Russian theatre manifests itself through the paradoxes of conflict in psychological drama. The unique (mentally deterministic) cultural dimension of the Russian drama forms a logical chain: time, space, and a person lost in time and space. The drama comes into the person’s life not only as a kind of literature, but also as a situation of their existence.Russian directing is defined as a mental/specific and, at the same time, civilizational/universal code. The civilizational discourse in the Russian, as well as the world theatre represents the paradox associated with the institutionalization of director’s profession as an embodiment of the demiurgic beginning and the sphere of self-realization of individual peculiarities of a creative personality (which can be seen in the experience of V. Meyerhold and E. Vakhtangov, G. Tovstonogov and Yu. Lyubimov, and many of the existing directors of today).An actor in Russia is more than an actor; paraphrasing the well-known formula, we pay attention to the characteristic of mental identity code inhe­rent in acting. The triad of playwright—director—actor undoubtedly forms the basis of the Russian artistic tradition and affirms the importance of professional intentions and the cultural and philosophical mea­ning of creative activity of each of the three authors of a theatrical work. The actor in this chain is the final link.The civilizational discourse, based on the universals of cultural practices, is associated with transformation of styles, methods, eternal matters, reflecting primarily in drama. The mental discourse, fully specific, is associated with local themes (acting) and paradoxical receptions of world practices and influence on them (directing).
The Influence of In-Service Preschool Teachers’ Education on their Perceived Competences for Counselling Parents
Authors: Mihić Sanja Skočić , Trošelj Danijela Blanuša , Katić Vesna 
Published: March 2019

With a half-century of tradition, early and preschool education in the Republic of Croatia is a highly organised system in which preschool teachers meet high professional standards. Among their professional requirements,they have been legally bound to counsel parents since 2008. However, no other documents or papers in Croatia describe or specify what counselling entails. The present research explored 136 preschool teachers and their self-assessment of competence in counselling parents. The results indicate that: (a) preschool teachers rate themselves moderately competent in counselling parents; (b) joining the in-service training is related to a higher level of their self-assessment in counselling parents. Although it is evident that they had acquired the competence for counselling parents during their personal and professional development, the in-service trainingplays the key role in providing it.
PEMAHAMAN ORANG TUA TERHADAP PENTINGNYA PENDIDIKAN ANAK USIA DINI
Authors: Apriyanti Helly 
Published: March 2019

Pendidikan anak usia dini tentunya tidak bisa diabaikan dari peran orang tua. Orang tua tentunya harus memahami akan pentingnya pendidikan bagi anak usia dini. Hal ini dimaksudkan agar pembentukan karakter bagi anak sudah ditanamkan sejak dini. Tujuan diadakannya penelitian deskriptif ini mengetahui sejauh mana orang tua memahami akan pentingnya pendidikan anak usia dini. Penelitian ini dilaksanakan di Desa Wancimekar Kecamatan Kotabaru Kabupaten Karawang, dengan populasi warga kampung Kalioyod dan sampelnya dilakukan dengan simple random sampling. Hasil analisis data yang sudah diolah menyimpulkan bahwa 78% orang tua memahami tentang sangat pentingnya pendidikan anak usia dini, sehingga dapat disimpulkan bahwa orang tua sudah paham akan pentingnya pendidikan anak usia dini.
The Transition of Family Business Leadership:
Authors: Kamener Dahliana , Rashid Norasekin Ab. , Puttri Daniati 
Published: March 2019

The issue of succession is very important because the successful succession leads to the sustainability of a family businesses (Sharma & Dave, 2013). Generally, the family businesses are difficult to flourish and even many have bankrupt. Some family businesses are bound on the first generation and some have collapsed in the second generation. Literature shows that just 30 percent of family businesses can be passed along to the second generation, and 70 percent fail after first generation step down because there are no preparation for succession and inability of the next generation to control and run the company (Aronoff, (2004). The study purposed to examine six hypotheses and the result showed the succession planning, non-family leadership, and decision making authority unsignificantly affect on the succession of the family business. Nevertheless, founder's influence, successor and strategic planning variable affect significantly to the success of family business succession at Padang city, West Sumatera.
Local Undergraduatesâ€™ Perceptions on Curriculum Internationalization:
Authors: Shuib Munir , Azizan Siti Norbaya 
Published: March 2019

The study findings revealed that curriculum internationalization is generally well-perceived by local undergraduates in the Malaysian public university. Specifically, the respondents agreed on the importance of internationalization of curriculum by their university. In their view, the internationalization elements have been integrated into the curriculum through various approaches by their lecturers, such as by infusing a global perspective in the lessons. Despite the perceived importance of curriculum internationalization, this study also reported that there are several barriers hindering local undergraduates to actively participate in internationalization activities, which include financial constraints and lack of awareness among the students about such programs and activities in their university.
Restraining the Proliferation of Acute Lymphoblastic Leukemia Cells by Genistein through Up-regulation of B-cell Translocation Gene-3 at Transcription Level
Authors: Abedi Nejad Masoumeh , Nikbakht Mohsen , Afsa Masoomeh , Malekzadeh Kianoosh 
Published: March 2019

Background: Acute lymphoblastic leukemia (ALL) is a highly prevalent pediatric cancer accounting for approximately 78% of leukemia cases in patients younger than 15 years old. Different studies have demonstrated that B-cell translocation gene 3 (BTG3) plays a suppressive role in the progress of different cancers. Genistein is considered a natural and biocompatible compound and a new anti-cancer agent. In this study, we evaluate the effect of genistein on BTG3 expression and proliferation of ALL cancer cells. Materials and Methods: ALL cell lines (MOLT4, MOLT17, and JURKAT) were cultured in standard conditions. Cytotoxicity of genistein was detected using MTT assay. The cells were treated with different concentrations of genistein (10, 25, 40, and 55μM) for 24, 48, and 72 hours, and then cell viability and growth rate were measured. The quantitative real-time polymerase chain reaction was applied to investigate the effect of genistein on BTG3 expression. Results: The percentage of vital cells treated with genistein significantly decreased compared to the non-treated cells, showed an inverse relationship with an increasing genistein concentration. The present study suggests a dose of 40μM for genistein as a potent anticancer effect. Genistein could elevate BTG3 for 1.7 folds in MOLT4 and JURKAT and 2.7 folds in MOLT17 cell lines at transcription level conveged with 60 to 90% reduction in the proliferation rate of cancer cells. Conclusion: Up-regulation of BTG3 as a tumor suppressor gene can be induced by genistein. It seems that BTG3 reactivation can be introduced as another mechanism of anti-proliferative effect of genistein and could be considered as a retardant agent candidate against hematopoietic malignancy.[GMJ. 2019;inpress:e1229]
Acute effects of reverse Kinesio Taping on knee muscle strength, fatigue index and H/Q ratio in healthy subjects
Authors: Doğan Erol , Yilmaz Ali Kerim , Özdal Mustafa , Mayda Muhammet Hakan , Yilmaz Çoşkun , Ermi̇ş Egemen 
Published: March 2019

BACKGROUND: Kinesio Tape (KT) is one of the most common taping methods used to prevent injuries, rehabilitate injured athletes, and improve muscle performance. But there are no studies investigating the acute effect of reverse taping on the isokinetic muscle strength. OBJECTIVE: To investigate the effects of KT applied to quadriceps (Q) and hamstring (H) muscles on knee extension (Ex) and flexion (Flx) strength, H/Q ratio, and fatigue index (FI). METHODS: In total, 17 healthy male subjects with a history of regular physical activity for at least 3 years participated in the study voluntarily. The muscle facilitation and muscle inhibition techniques of KT were applied in reverse direction to the Q and H muscles, and concentric/concentric isokinetic Ex and Flx strengths of the knee were measured at 60, 180, and 240[Formula: see text]/s. Isokinetic Ex and Flx strengths were measured without any application of KT, in trial 1 (T1). In trial 2 (T2), muscle facilitation was applied to Q, and muscle inhibition was applied to H. In trial 3 (T3), muscle facilitation was applied to H, and muscle inhibition was applied to Q. A body analyzer was used for height, weight, and body mass index (BMI) values. RESULTS: As for the strength, T2 showed higher scores compared to T1 and T3 at all angular velocities ([Formula: see text] 0.05). The values of the H/Q ratio at T2 were higher than at T1 at 180 and 240[Formula: see text]/s ([Formula: see text] 0.05). No significant difference was found in the mean FI values between the trials at any of the test velocities. CONCLUSIONS: Simultaneous facilitation and inhibition, applied to Q and H, respectively, had a positive effect on both the Ex and Flx strengths and also on H/Q ratio at high angular velocities (180[Formula: see text] and 240[Formula: see text]) in healthy individuals. The mechanism responsible for this improvement is probably associated with creating different tensions in Q and H muscle groups by the reverse application of KT.
CORRELATION BETWEEN SERUM CALCIUM LEVELS AND SMEAR GRADING AMONG THE PULMONARY TUBERCULOSIS PATIENTS
Authors: Sood Pramod , Bhat Sanjay 
Published: March 2019

Background: Tuberculosis (TB) is contagious and airborne. TB was one of the top 10 causes of death worldwide in 2017. It is also the leading killer of people with HIV and a major cause of deaths related to antimicrobial resistance.
Methods: Microscopically confirmed TB patients were included in the cases group and healthy individuals in the control group. Serum Ca was estimated by kit method, by auto analyzer. ANOVA and t- test was used to find the statistical significance.
Results: The mean serum Ca was 7.32±1.22 mg/dl in TB and 9.41±2.13 mg/dl in controls. The mean serum Ca levels were 7.22±1.20 mg/dl, 7.14±1.14 mg/dl, 7.12±1.10 mg/dl and 7.06±1.02 mg/dl respectively for scanty, 1+. 2+ and 3+; statistically the difference were not significant (P > 0.05) between the grades.
Conclusion: Hypocalcemia observed in pulmonary tuberculosis patients. No correlation was found between the mean serum Ca levels and grading.
Keywords: Calcium, TB, AFB.
SAMED BEHRENGÎ’NİN ESERLERİNDE ÇOCUK
Authors: Sarpkaya Seçkin 
Published: March 2019

Samed
Behrengî, İran Türk çocuk edebiyatının önde gelen isimlerinden biridir.
Eserlerini Farsça yazmak zorunda kalan Behrengî’nin pek çok çalışması dilimize çevrilmiştir.
Behrengî iyi bir masal yazarı ve derlemecisidir. Yazarlığının yanında öğretmenlik
ve gazetecilik de yapan Behrengî,
özellikle Azerbaycan folkloru üzerine derlemeleri ve çalışmalarıyla Türk kültürü için önemli hizmetler
gerçekleştirmiştir. Behrengî’nin Türkçeye çevrilen ve çocuklara yönelik
masalları ve masal tarzındaki hikâyeleri, çocukluğa ve çocuk gelişimine dair
birçok düşünce ve ileti içermektedir. Behrengî, yazdıklarıyla çocukların
kazanması gereken çeşitli özellikler ve kabiliyetlere dair düşüncelerini
işlemiştir. Bu makalede Behrengî’nin masal ve hikâyelerindeki çocuk teması incelenecektir.
İlk olarak çeşitli kaynaklardan hareketle Samed Behrengî’nin hayatı ve edebi
kişiliği hakkında bilgi verilecek, bunu takiben masal türünün işlev
özelliklerine kısaca değinilecektir. Daha sonra Behrengî’nin eserlerinde anne,
baba ve çocuk tipleri incelenecek ve yazarın aileyle ilgili düşüncelerine yer
verilecektir. Bu inceleme yapılırken ebeveynlerin ve çocuğun ailedeki konumuna
göre değerlendirmeler yapılacaktır. Sonuç olarak Behrengî’nin masal ve
hikâyelerinde aile ve çocuk düşüncesinin genel yapısı ve çocuklara yönelik
iletiler tespit ve tahlil edilecektir.