bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of cadmium adsorption from aqueous solutions by functionalized graphene and the reversible magnetic recovery of the adsorbent using response surface methodology
Authors: Jafaryan Aynaz , Sadjadi Sodeh , Gharib Ahmad , Ahmadi Seyed Javad 
Published: July 2019

Novel functionalized graphene adsorbent was prepared and characterized using different techniques. The prepared adsorbent was applied for the removal of cadmium ions from aqueous solution. A response surface methodology was used to evaluate the simple and combined effects of the various parameters, including adsorbent dosage, pH, and initial concentration. Under the optimal conditions, the cadmium removal performance of 70% was achieved. A good agreement between experimental and predicted data in this study was observed. The experimental results revealed of cadmium adsorption with high linearity follow Langmuir isotherm model with maximum adsorption capacity of 502 mg g−1, and the adsorption data fitted well into pseudo‐second order model. Thermodynamic studies showed that adsorption process has exothermic and spontaneous nature. The recommended optimum conditions are: cadmium concentration of 970 mg L−1, adsorbent dosage of 1 g L−1, pH of 6.18, and T = 25 °C.The magnetic recovery of the adsorbent was performed using a magnetic surfactant to form a noncovalent magnetic functionalized graphene. After magnetic recovery of the adsorbent both components (adsorbent and magnetic surfactant) were recycled by tuning the surface charges through changing the pH of the solution. Desorption behavior studied using HNO3 solution indicated that the adsorbent had the potential for reusability.
Microwave assisted synthesis of disubstituted benzyltin arylformylhydrazone complexes: anticancer activity and DNA‐binding properties
Authors: Jiang Wu‐Jiu , Zhou Qian , Liu Meng‐Qin , Zhang Fu‐Xing , Kuang Dai‐Zhi , Tan Yu‐Xing 
Published: July 2019

Eight disubstituted benzyltin complexes, i.e., {[R(O)C=N‐N=C (Me)COO]R'2Sn(CH3OH)}n (1a and 2b), {[R(O)C=N‐N=C (Me)COO]R'2Sn(CH3OH)}2 (1b and 1d) and {[R(O)C=N‐N=C (Me)COO]R'2Sn}n (1c, 2a, 2c, and 2d) (R = C4H3O‐, C4H3S‐, p–t‐Bu‐C6H4‐ or p‐MeO‐C6H4‐; R' = o‐Cl‐C6H4CH2‐ or o‐Me‐C6H4CH2‐), were prepared from the reaction of arylformylhydrazine, pyruvic acid and disubstituted benzyltin dichloride with microwave irradiation. All complexes were characterized by FT‐IR spectroscopy, 1H, 13C and 119Sn NMR spectroscopy, HRMS, elemental analysis, X‐ray single‐crystal diffraction and TGA. The in vitro antitumour activities of all complexes were evaluated by an MTT assay against three human cancer cell lines (NCI‐H460, HepG2, and MCF7). 2b exhibited strong antitumour activity on HepG2 cells and was expected to be a suitable platform for further chemical optimization to develop as anticancer therapeutics. The DNA binding of 2b was studied by UV–visible absorption spectrometry, fluorescence competitive assays, viscosity measurements and gel electrophoresis. Molecular docking was used to predict the binding between 2b and DNA, and the results show that 2b can become embedded in the double helix of DNA and cleave DNA.
The effect of inlet shape on separation performance and flow‐field characteristics in a gas–solid cyclone separator
Authors: Wei Qing , Sun Guogang , Jiao Yunnan , Han Xiao , Zhang Yong 
Published: July 2019

AbstractThe gas–solid separation experiments were conducted to compare separation performance between cyclone separators with different inlet shapes. Besides, the Reynolds stress model was employed to simulate flow field in different cyclones. The results revealed that the cyclone with a trapezoidal inlet could enhance separation efficiency without almost increasing pressure drop. Compared with the conventional rectangular inlet, a trapezoidal inlet had negligible effect on flow field of cyclone's separation space, and it reduced lip flow and upper dust ring of cyclone. In addition, the cyclone with a trapezoidal inlet could improve the inhomogeneous gas flux distribution at the inlet, which was the root reason why secondary flows in cyclone were inhibited and separation efficiency was enhanced.
Optimization method to select temperature based on chemorheological and exothermal reaction of RTM
Authors: Yang Wenkai , Lu Shihong , Liu Wenhao 
Published: July 2019

ABSTRACTHeating mold and resin have been widely used in resin transfer molding (RTM) to improve injection and manufacturing efficiency. The unreasonable mold/resin temperatures sometimes lead to excessive viscosity of resin and premature curing, which will result in failure of the filling process. Selection of optimal mold and resin temperature has become a source of concern in the polymer industry. This article presents an optimization method to select mold and injection resin temperatures by using numerical simulation based on chemorheological and exothermal reaction of the RTM process. The results show that the optimization method has high computational efficiency for three‐dimensional parts with different shapes. The selected mold/resin temperature ensures the smooth filling process, which provides a powerful tool for parameter design in polymer industry. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019,136, 48245.
Characterization of microsatellite markers for the endangered Daphne rodriguezii (Thymelaeaceae) and related species
Authors: García‐Verdugo Carlos , Illera Juan Carlos , Traveset Anna 
Published: July 2019

PremiseThe endangered shrub Daphne rodriguezii (Thymelaeaceae) is endemic to the Balearic island of Menorca, where fragmentation and severe population decline are ongoing threats to this taxon. We developed a set of microsatellite markers to analyze the fine‐scale genetics of its few extant populations.Methods and ResultsFifteen microsatellite markers were obtained through Illumina high‐throughput sequencing and tested in two populations. Twelve of these loci showed no evidence of null alleles and were highly polymorphic, with a mean number of 8.3 alleles per locus. Levels of observed and expected heterozygosity ranged from 0.100 to 0.952 and from 0.095 to 0.854, respectively. Seven to nine of these loci were successfully amplified in five other Daphne species.ConclusionsThis set of markers provides a useful tool for investigating the factors driving fine‐scale population structure in this threatened species, and it represents a novel genetic resource for other European Daphne species.
Systematic review of factors that may influence the outcomes and generalizability of parent‐mediated interventions for young children with autism spectrum disorder
Authors: Trembath David , Gurm Mandeep , Scheerer Nichole E. , Trevisan Dominic A. , Paynter Jessica , Bohadana Gal , Roberts Jacqueline , Iarocci Grace 
Published: July 2019

Parent mediated interventions have the potential to positively influence the interactions and developmental outcomes of children with autism spectrum disorder (ASD). However, a range of factors relating to children, parents and caregivers, and study design may impact on outcomes and thus the generalizability of these interventions to the broader community. The objective of this review was to examine factors that may influence the feasibility, appropriateness, effectiveness, and generalizability of parent mediated interventions for children with ASD. We conducted a systematic review, yielding 41 articles. There was substantial variability in the intervention type, intensity, and study quality. Notably, 46 different inclusion/exclusion criteria were reported across studies including factors relating to children's development, access to other services, comorbidities, parental factors, and access to the intervention. Fifteen articles included examination of 45 different factors potentially associated with, or influencing, intervention outcomes including child (e.g., language skills, ASD severity, cognition) and parent (e.g., adherence and fidelity, education) factors. Although there is clear evidence for an increasingly sophisticated (e.g., systematic phased research for some interventions) and diverse (e.g., studies in geographical diverse contexts including low‐resource communities) approach to research examining parent mediated interventions, there remains a need for improved study quality and measurement consistency in research, including a detailed examination of factors that may predict, moderate, and mediate intervention effectiveness for children and their parents. Autism Res 2019, 12: 1304–1321. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryParent mediated interventions—in which parents adapt their own behavior or deliver interventions to help their children learn—appear to be effective for some children with autism spectrum disorder. In this review, we identified a range of child, parent, and study design factors that may influence intervention outcomes and ultimately the uptake of these approaches in the community. We suggest that research in this area could be further improved by ensuring that studies include diverse groups of children and parents, and by using study designs that help to establish not only if interventions work, but for whom they work best and why.
Selective sensing Ca2+ with a spiropyran‐based fluorometric probe
Authors: Wang Li , Yao Yuanjun , Wang Jiao , Dong Chuan , Han Hui 
Published: July 2019

AbstractSpiropyran (SP) and its derivatives operate between their ring opening and closing forms as a versatile molecular platform for the fluorescence detection of cations and anions, using a colour change for signalling. A functionalized SP fluorescence probe, L, was prepared and characterized. Probe L can detect Ca2+ with a fluorescence ‘turn‐on’ response in ethanol solution. It selectively binds Ca2+ to form a 1:1 ligand/metal complex, which produced a new emission band centred at 604 nm. The sensing result was clearly observed by the solution colour change from colourless to pink under visible light, and from blue to red under ultraviolet light. The detection limit was calculated to be 4.53 × 10−8 M for Ca2+. The probe provides another possibility that SP‐based derivatives could be used for the development and detection of metal ions in environmental and physiological systems.
In vitro lung cancer multicellular tumor spheroid formation using a microfluidic device
Authors: Lee Sang Woo , Hong Soyoung , Jung Boyoung , Jeong Soo Yeon , Byeon Jae Hee , Jeong Gi Seok , Choi Jaesoon , Hwang Changmo 
Published: July 2019

AbstractThe purpose of this study was to demonstrate self‐organizing in vitro multicellular tumor spheroid (MCTS) formation in a microfluidic system and to observe the behavior of MCTSs under controlled microenvironment. The employed microfluidic system was designed for simple and effective formation of MCTSs by generating nutrient and oxygen gradients. The MCTSs were composed of cancer cells, vascular endothelial cells, and type I collagen matrix to mimic the in vivo tumor microenvironment (TME). Cell culture medium was perfused to the microfluidic device loaded with MCTSs by a passive fluidic pump at a constant flow rate. The dose response to an MMPs inhibitor was investigated to demonstrate the effects of biochemical substances. The result of long‐term stability of MCTSs revealed that continuous perfusion of cell culture medium is one of the major factors for the successful MCTS formation. A continuous flow of cell culture medium in the in vitro TME greatly affected both the proliferation of cancer cells in the micro‐wells and the sustainability of the endothelial cell‐layer integrity in the lumen of microfluidic channels. Addition of MMP inhibitor to the cell culture medium improved the stability of the collagen matrix by preventing the detachment and shrinkage of the collagen matrix surrounding the MCTSs. In summary, the present constant flow assisted microfluidic system is highly advantageous for long‐term observation of the MCTS generation, tumorous tissue formation process and drug responses. MCTS formation in a microfluidic system may serve as a potent tool for studying drug screening, tumorigenesis and metastasis.
Generation and characterization of Suncus murinus intestinal organoid: a useful tool for studying motilin secretion
Authors: Takakura Natsumi , Takemi Shota , Kumaki Shunsuke , Matsumoto Mio , Sakai Takafumi , Iwatsuki Ken , Sakata Ichiro 
Published: July 2019

AbstractMotilin, a 22‐amino‐acid peptide produced in the upper small intestine, induces strong gastric contraction in fasted state. In many rodents, motilin and its cognate receptors exist as pseudogenes, which has delayed motilin research in the past decades. Recently, the house musk shrew (Suncus murinus) was developed as a useful model for studying motilin and gastrointestinal motility. However, due to a lack of motilin‐producing cell lines and difficulties in culturing small intestinal cells, the regulatory mechanisms of motilin secretion and its messenger RNA (mRNA) transcription have remained largely unclear. In this study, we generated small intestinal organoids from S. murinus for the first time. Using methods similar to mouse organoid generation, we found crypt‐like budding structures 3 days after isolating intestinal tissues. The organoids grew gradually with time. In addition, the generated organoids were able to be passaged and maintained for 6 months or longer. Motilin messenger RNA (mRNA) and immunopositive cells were observed in both S. murinus intestinal organoids and primary tissues. This is the first report of intestinal organoids in S. murinus, and our results suggest that S. murinus intestinal organoids could be useful for analyzing motilin secretion and transcription.
Metformin facilitates the proliferation, migration, and osteogenic differentiation of periodontal ligament stem cells in vitro
Authors: Zhang Rui , Liang Qianyu , Kang Wenyan , Ge Shaohua 
Published: July 2019

AbstractPeriodontitis is one of the main causes of tooth loss and has been confirmed as the sixth complication of diabetes. Metformin promotes the osteogenic differentiation of stem cells. Periodontal ligament stem cells (PDLSCs) are the best candidate stem cells for periodontal tissue regeneration. Herein, we aimed to identify the effects of metformin on the proliferation, migration, and osteogenic differentiation of PDLSCs in vitro. PDLSCs were isolated by limiting dilution, and their characteristics were assessed by colony formation assay and flow cytometry. Cell counting and migration assays were used to investigate the effects of metformin on proliferation and migration. The osteogenic differentiation ability of PDLSCs was detected by alkaline phosphatase (ALP) activity and Alizarin Red S staining. Gene and protein levels of osteogenesis‐related markers were determined by quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blot analysis, respectively. Metformin treatment at 10 μM did not affect PDLSC proliferation, while at 50 and 100 μM, metformin time‐dependently enhanced PDLSC proliferation and significantly increased cell numbers after 5 and 7 days of stimulation (P <
0.05). In addition, 50 μM metformin exhibited a maximal effect on migration, ALP activity, and mineral deposition (P <
0.05). Furthermore, 50 μM metformin significantly upregulated the gene expression levels of ALP, BSP, OPN, OCN, and Runx2 and the protein expression of ALP and Runx2 (P <
0.05). In summary, our study confirms that metformin facilitates the proliferation, migration, and osteogenic differentiation of PDLSCs in vitro and could be used as a new strategy for periodontal tissue regeneration.
Heterostructured Nickel‐Cobalt Selenide Immobilized onto Porous Carbon Frameworks as an Advanced Anode Material for Urea Electrocatalysis
Authors: Khalafallah Diab , Ouyang Chong , Zhi Mingjia , Hong Zhanglian 
Published: July 2019

AbstractTransition‐metal selenides based materials have recently aroused an increasing consideration in the field of energy reservation and conversion owing to their good electrochemical performance and low synthetic cost. Herein, multi‐walled carbon nanotubes supported binary nickel cobalt selenide composite (Ni−Co−Se/CNT) was prepared by a one‐pot‐hydrothermal method using hydrazine ions that enables the selenium to diffuse and react with the Ni‐and Co‐cations to form Ni−Co−Se with a stable nanostructure onto the outer walls of the CNT platforms due to the coordination interaction between the metallic cations and surface oxygen‐containing group of the conductive scaffolds. The electrochemical performances for urea oxidation reaction (UOR) are accessed in an alkaline medium by cyclic voltammetry (CV), chronopotentiometry (CA), and electrochemical impedancespectroscopy (EIS) tests. The as‐prepared Ni−Co−Se/CNT hybrid presents an excellent electrocatalytic activity in terms of current density and onset potential due to synergistic effects of tubular CNT scaffolds, additional Co active sites, and electrochemically active NiOOH layer. The CNTs support markedly enhanced the electrocatalytic properties by providing a rapid mass transport for UOR because of their porous network architectures with a robust adhesion to the Ni−Co−Se nanocrystals. Thus, the synthetic methodology synthetic methodology adopted here is entirely effective for constructing various metal selenide compounds in future.
Effective asymmetric Michael addition of anthrone to nitroalkenes using chiral tetraoxacalix[2]arene[2]triazines as organocatalysts
Authors: Genc Hayriye Nevin 
Published: July 2019

AbstractNovel chiral secondary amines bearing a tetraoxacalix[2]arene[2]triazine scaffold were created and used for catalytic asymmetric Michael reaction of anthrone with nitroalkenes. The relevant adducts were obtained in good to excellent yields (82%‐98%) and enantioselectivities (75%‐98%).
Interfacial Study of Nickel‐Modified Pt(111) Surfaces in Phosphate‐Containing Solutions: Effect on the Hydrogen Evolution Reaction
Authors: Sarabia Francisco J. , Climent Víctor , Feliu Juan M. 
Published: July 2019

AbstractThe surface modification of electrodes attracts great interest in electrocatalysis. It has often been observed that deposition of foreign adatoms on the surface of an electrode can originate a significant enhancement in the catalytic activity. For example, it has been reported that nickel deposits on Pt surfaces improve the rate of the hydrogen evolution reaction (HER, Nature Energy 2017, 2, 17031). During the deposition process of such metal adlayers, the pH and the nature of the ions in the electrolyte play an important role. Phosphate species are typically used to prepare buffer solutions in a wide range of pH. Therefore, electrolytes containing phosphate species are used in a large number of applications. However, the effect of phosphate on platinum surface modification with nickel deposits has not been studied yet. In this work, new data about the interaction of phosphate with nickel adatoms deposited on Pt(111) at pH 5 is investigated using cyclic voltammetry and infrared spectroscopy. The results show that, when nickel is in solution, the phosphate ions are adsorbed at lower potentials than in the absence of nickel. In addition, Laser‐Induced Temperature Jump Technique demonstrates that nickel facilitates the adsorption of phosphate because of a shift of the potential of zero charge (pzc) toward negative potentials. This increases the magnitude of the positive electric field on the electrode surface, at a given potential E>pzc, facilitating the adsorption of anions. CO displacement technique has been also employed to obtain additional information about co‐adsorbed phosphate on nickel adlayers. Finally, the HER has been studied at pH 5 in the presence of nickel, with and without phosphate in the bulk solution.
Can a firm's environmental innovation attract job seekers? Evidence from experiments
Authors: Liao Zhongju , Cheng Jialin 
Published: July 2019

AbstractBased on social identity theory, this study proposes a model to explore the link between the environmental innovation perceived by job seekers and a firm's attractiveness by focusing on the mediating role of pride and the moderating role of moral identity. We tested our hypotheses using two experiments. The results showed that a firm's environmental innovation was related positively to a firm's attractiveness and that this relationship was mediated by job seekers' pride. In addition, moral identity played positive moderating role between environmental innovation and job seekers' pride. The findings of this study provide theoretical contributions and managerial implications that indicate new directions for research related to environmental innovation and a firm's attractiveness.
Hürthle cell lesions on thyroid fine needle aspiration cytology: Molecular and histologic correlation
Authors: Schatz‐Siemers Nina , Brandler Tamar C , Oweity Thaira , Sun Wei , Hernandez Andrea , Levine Pascale 
Published: July 2019

AbstractBackgroundHürthle cell lesions often pose diagnostic challenges, despite their common occurrence on thyroid fine‐needle aspiration cytology (FNAC). The associated molecular alterations are also not well understood. Therefore, our study aimed to delineate the molecular profile of Hürthle cell lesions classified as Bethesda Categories III or IV (atypia of undetermined significance (AUS) or suspicious for follicular neoplasm (SFN)) on FNAC and to correlate this molecular profile with surgical resection findings.MethodsThis study consisted of 188 Hürthle cell lesions with indeterminate cytology and ThyroSeq® v2/v3 molecular testing results. Surgical follow‐up was available for 33 cases.ResultsThe majority of indeterminate Hürthle cell lesions had negative ThyroSeq® results (61%) and were benign on available surgical follow‐up. The most prevalent mutations involved the RAS gene (21%), which were associated with benign lesions, non‐invasive follicular thyroid neoplasms with papillary‐like nuclear features (NIFTP), and malignancy. The remaining mutations involved less than 18% of the cases, including PAX8/PPARG (3.7%), TSHR (3.7%), EIF1AX (2.7%), MET (2.1%), PTEN (1.6%), clonal copy number alteration (1.6%), TERT (1.1%), and 0.5% each of GNAS, PIK3CA, and TP53 mutations. On follow‐up, 45% were benign, 24% were NIFTP, and 30% were malignant. The malignant cases had different molecular alterations.ConclusionNo single molecular alteration defines cytologically indeterminate Hürthle cell lesions; the majority of cases have low‐risk or no molecular alterations and are benign on follow‐up. These findings suggest that molecular testing may be useful, but is not definitive, in determining which cases may be managed conservatively; additional studies are needed to fully determine the negative predictive value in ruling out malignancy.