bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibrin Gel Network Characteristics and Coronary Heart Disease: Relations to Plasma Fibrinogen Concentration, Acute Phase Protein, Serum Lipoproteins and Coronary Atherosclerosis
Authors: Fatah Kamaran , Hamsten Anders , Blombäck Birger , Blombäck Margareta 
Published: July 2018

SummaryThe native fibrin gel structure formed in vitro from plasma samples was examined by liquid permeation of the hydrated fibrin gel networks in 18 men who had suffered a myocardial infarction before the age of 45 years and in 20 control subjects. Patients with an elevated plasma fibrinogen concentration had a considerably lower fibrin gel porosity (permeability coefficient, K
s) compared with patients with a normal plasma fibrinogen level and with controls. The calculated fiber mass-length ratio of the fibrin gel networks was decreased in both patient groups. Gel porosity differed markedly between individuals at a given plasma fibrinogen concentration. Fairly strong inverse correlations were found between plasma orosomucoid level on the one hand and K
s (r = –0.617, p <0.01) or fiber mass-length ratio (r = –0.499, p <0.05) on the other. The low density lipoprotein (LDL) cholesterol concentration also correlated inversely with K
s (r = –0.471, p <0.05) and fiber mass-length ratio (r = –.522, p <0.05). Significant inverse relations, which were independent of plasma fibrinogen and lipoprotein concentrations, were detected between K
s (r = –.519, p <0.05) and calculated fiber mass-length ratio (r = –.723, p <0.001) and number and severity of coronary artery stenoses determined by angiography. A proneness to formation of tight, rigid and space-filling fibrin network structures with small pores thus appears to be associated with premature coronary artery disease.
The Consumption of Antithrombin III During Coagulation, Its Consequences for the Calculation of Prothrombinase Activity and the Standardisation of Heparin Activity
Authors: Béguin S , Kessels H , Dol F , Hemker H C 
Published: July 2018

SummaryThe decay rate of thrombin in plasma is shown to be linearly proportional to the concentration of antithrombin III (AT III), not only in the absence but also in the presence of heparin. This is a consequence of partitioning of heparin between AT III and other plasma proteins.In previous articles we calculated the prothrombin converting activity assuming a fixed concentration of AT III. Since AT III is consumed during the clotting process, prothrombinase activity is more accurately approximated using an algorithm that counts with the decrease of the AT III concentration. It is shown this leads to higher prothrombinase activities. The (absence of) inhibition of prothrombin conversion by prothrombinase in the presence of heparins found with the previous method is also found using the new algorithm.From the results presented it is evident that characteristic parameters of heparin action have to be normalised to the AT III concentration. On this basis we define a Standard Independent Unit of the antithrombin activity of heparin.
Depression of Tissue-Type Plasminogen Activator and Enhancement of Urokinase-Type Plasminogen Activator as an Expression of Local Inflammation
Authors: Brommer Emile J P , Dooijewaard Gerard , Dijkmans Ben A C , Breedveld Ferdinand C 
Published: July 2018

SummaryInflammatory processes are accompanied by extravascular deposition and breakdown of fibrin. We measured fibrinolytic parameters in synovial fluid (SF) and in plasma of 36 patients with rheumatoid arthritis (RA). As a control, SF of 13 patients with blunt knee trauma, and plasma of 17 healthy volunteers were studied. In RA patients, extravascular t-PA mediated plasminogen activation was depressed: mean SF tissue-type plasminogen activator (t-PA:Ag) concentration (2.1 ± 1.6 ng/ml) was four-fold lower, and plasminogen activator inhibitor (PAI) activity (284 ± 212%) four-fold higher than the plasma values of the same patients or of healthy donors. In contrast, u-PA related plasminogen activation was strongly enhanced: urokinase-type plasminogen activator (u-PA) antigen (23.1 ±12.4 ng/ml) was more than four-fold higher, single-chain u-PA (scu-PA) (5.3 ± 1.9 ng/ml) three-fold higher than in plasma of the same patients or of healthy donors, and active two-chain u-PA (tcu-PA) was detected in 14 of the 36 SF samples of RA patients. All of these changes in extravascular fibrinolytic parameters correspond with those induced by inflammatory mediators in cell cultures. In joint effusions of patients with a blunt knee trauma, the effects were intermediate: u-PA related parameters showed moderate changes in the same direction as in arthritis; t-PA antigen was also decreased. The only exception was that PAI was not increased. We conclude that the findings in traumatic effusions reflect transient effects as a reaction to trauma. In joint inflammation, the depressed t-PA mediated plasminogen activation, although more than compensated by the enhanced u-PA mediated plasminogen activation, results in protraction of fibrin removal. Besides, the enhanced u-PA activation might lead to proteolytic damage of the cartilage.
Intravenous Acetylsalicylic Acid – Dose-Related Effects on Platelet Function and Fibrinolysis in Healthy Males
Authors: Husted S E , Kristensen S D , Vissinger H , Mørn B , Schmidt E B , Nielsen H K 
Published: July 2018

SummaryLow-dose acetylsalicylic acid (ASA) has been shown to be beneficial in patients with acute myocardial infarction and unstable angina pectoris. Oral administration of ASA is difficult in the acute phase of these syndromes. In this study we evaluated the effect of 25 mg, 50 mg or 100 mg of ASA given as an intravenous bolus injection on platelet function and fibrinolysis in healthy males and related this to plasma concentrations of ASA. No adverse effects were found. A complete inhibition of serum thromboxane B2 synthesis was demonstrated 5 min after injection of 100 mg ASA intravenously. ASA disappeared from the circulation within 60 min after bolus injection and at this time thromboxane B2 synthesis was inhibited dose-dependently by 71%, 90% and 100% for doses of 25 mg, 50 mg and 100 mg, respectively. Inhibition of thromboxane B2 synthesis after 100 mg of intravenous ASA was still 96.5% at 24 h and 93.4% at 48 h after the injection. The bleeding time measured at 30 min after ASA administration was significantly prolonged on the average by 70 s, 144 s and 211 s after 25 mg, 50 mg and 100 mg of ASA, respectively. Minor, but significant changes were found in tissue plasminogen activator antigen and in plasminogen activator inhibitor within the first hour after injection of low dose ASA, but similar changes were found after injection of saline. No change in tissue plasminogen activator activity was found. We conclude, that intravenous administration of low dose ASA is safe and easy, and that almost immediate, complete blockage of serum thromboxane B2 synthesis can be obtained after a single intravenous bolus injection of 100 mg.
An Update on Unloading Knee Braces in the Treatment of Unicompartmental Knee Osteoarthritis from the Last 10 Years: A Literature Review
Authors: Mistry Dylan , Chandratreya Amit , Lee Paul 
Published: July 2018

Background The incidence of osteoarthritis is increasing and it is one of the most common causes of chronic conditions. Total knee replacement is the mainstay of treatment for end-stage knee osteoarthritis; however, with long waiting lists and high levels of dissatisfaction, a treatment like knee braces could potentially delay surgery. Unicompartmental knee osteoarthritis is associated with misalignment of the knee, and unloader bracing has been recommended by various guidelines to correct this misalignment. The aim of this report was to provide an update of evidence from the past 10 years on knee braces.
Methods MEDLINE/EMBASE search was performed from the past 10 years.
Results We reviewed the evidence from 14 published articles. Almost all articles supported knee brace use and showed it to decrease pain, improve function, and improve the quality of life of patients. One study in 2017 followed patients for long term and found knee bracing to be more cost effective than total knee replacement, and could replace the need for surgery. Several minor complications were reported with bracing, like soft tissue irritation, which could be due to poor fitting. A management strategy for this could be regular follow-up at a nurse-led clinic.
Conclusions Unloader braces are an economical and effective treatment for unicompartmental knee osteoarthritis. They can significantly improve a patient's quality of life and potentially delay the need for surgery. Patients should be managed with a multidisciplinary approach with conservative management and knee bracing, before surgery is considered.
Pituitary Stalk Interruption Syndrome: Presentation of a Rare Case
Authors: Agridag Ucpinar Burcin , Ucar Ahmet , Ozmen Evrim 
Published: July 2018

AbstractPituitary stalk interruption syndrome is a congenital anomaly characterized by interrupted or thin pituitary stalk, hypoplastic or absent anterior pituitary, and an absent or ectopic posterior pituitary gland. The exact incidence rate of this syndrome is not known. However, the estimated incidence rate is 0.5/1,000,000 births. In this case report, we wanted to present a case of interrupted pituitary stalk syndrome, which presented with seizures and thyroid hormone deficiency. A 5-year-old female patient was admitted to our emergency department with vomiting, fever, and seizures with new onset. She had a twin who was ex-utero intrapartum in taken history. She was diagnosed with hypothyroidism and started on levothyroxine. Her height was in 25 to 50th percentile and her weight was in 10 to 25th percentile. She had mild mental retardation. On contrast-enhanced cranial magnetic resonance imaging scan, the pituitary stalk was absent, posterior pituitary was ectopic, and anterior pituitary was hypoplastic. The patient was diagnosed with interrupted pituitary stalk syndrome. After the symptoms were relieved, patient started on carbamazepine for epileptic seizures and hormone replacement therapy with levothyroxine and hydrocortisone. She was routinely followed up after the proper diagnosis. Leuprolide (gonadotropin-releasing hormone) and Norditropin (biosynthetic growth hormone) were added to medical therapy. Her height and weight were in 25th percentile after the long-term follow-up of approximately 10 years. On neurological examination, situation of mild mental retardation persisted. Pituitary stalk interruption syndrome is a very rare entity. However, radiologists should keep this syndrome in mind for patients who present with hypoglycemia, seizures, jaundice, cryptorchidism, and hypothyroidism in neonatal period and growth retardation with pituitary hormone deficiencies in childhood.
Ethische Betrachtungen zur Elternschaft psychisch Erkrankter
Authors: Jordan Wolfgang 
Published: July 2018

ZusammenfassungDie ethische Diskussion einer Elternschaft psychisch Erkrankter wird auf der Individual-, Struktur- und Systemebene des deutschen Gesundheitssystems vorgenommen. Das „Konzept des ethischen Therapeuten“ bietet eine Lösungsperspektive für die Individualebene, wohingegen strukturelle und systemische Probleme institutionelle und politische Lösungen erfordern. Der „Ethische Kompass psychiatrischer Elternschaft“ bewegt sich zwischen den Dimensionen Selbst-, Fremdbestimmung, Eigen- und Gemeinsinn. Eine Reduktion psychosozialer Belastungen, eine altersabhängige differenzierte Prävention und eine frühzeitige Unterstützung können zu einer gelungenen Elternschaft psychisch Erkrankter beitragen.
Ist Glück „machbar“?
Authors: Birnbacher Dieter 
Published: July 2018

ZusammenfassungPsychiatrie und Psychotherapie machen es sich u. a. zur Aufgabe, Menschen die Erfahrung von Glück zu ermöglichen. Insofern hängt ihre Existenzberechtigung an der – wie immer begrenzten – „Machbarkeit“ von Glück. Eine solche „Machbarkeit“ ist in der Geschichte der Philosophie und Psychologie immer wieder infrage gestellt worden. Der Beitrag diskutiert 4 Argumente, die gegen eine „Machbarkeit“ von Glück vorgebracht worden sind: das „Glücksparadox“, die irreduzible Subjektivität von Glück, die Variabilität der Glücksvorstellungen und die Theorie der vollständigen genetischen Determiniertheit des Glücksempfindens.
Das Glück des Psychotherapeuten
Authors: Kottje-Birnbacher Leonore 
Published: July 2018

ZusammenfassungBerufsarbeit ermöglicht die Erfahrung von Selbstwirksamkeit, stabilisiert den Selbstwert und gewährleistet Zugehörigkeit. Wieweit erfüllt der Beruf des Psychotherapeuten diese Desiderate? Der Beitrag skizziert die Bedingungen, die zusammenkommen müssen, wenn Psychotherapeuten nicht nur anderen zum Glück verhelfen, sondern selbst ihre Tätigkeit als erfüllend empfinden sollen. Hinter der hohen durchschnittlichen Zufriedenheit der Therapeuten mit ihrem Beruf verbergen sich Unterschiede im Umgang mit der Arbeit und in der Zufriedenheit, die sich wesentlich auf den Therapieerfolg auswirken. Daher sollten Therapeuten im Eigeninteresse und im Patienteninteresse versuchen, durch Fortbildungen, Intervision und Supervision den eigenen Arbeitsstil möglichst gut zu gestalten.
Dimensionen von Glück und Zufriedenheit bei beruflich psychiatrisch Pflegenden und in der psychiatrischen Pflege
Authors: Hahn Birgit , Nienaber André , Schulz Michael 
Published: July 2018

Zusammenfassung
Ziel der Studie Ziel dieses Beitrags ist es, wesentliche Aspekte der Konzepte Glück und Zufriedenheit im Hinblick auf die Arbeit in der psychiatrischen Pflege zu diskutieren.
Methodik Aspekte der Persönlichkeit, des Arbeitsumfelds und der Charakter der Arbeit werden beschrieben und Fallbeispiele aus dem ortsansässigen psychiatrischen Krankenhaus diskutiert.
Ergebnisse Glück und Zufriedenheit sind bei psychiatrisch Pflegenden abhängig von Kontextfaktoren und ihren individuellen Erlebnissen in konkreten Pflegesituationen.
Schlussfolgerung Glück und Zufriedenheit beeinflussen die Pflege- und Behandlungsqualität. Darüber hinaus ist die empfundene Berufszufriedenheit ein wichtiger Faktor im Hinblick auf die Frage, ob sich Pflegende für die Arbeit in der Psychiatrie entscheiden und wie lange sie in dem Beruf bleiben.
Ferroelectric domain wall dynamics characterized with X-ray photon correlation spectroscopy
Authors: Gorfman Semën , Bokov Alexei A. , Davtyan Arman , Reiser Mario , Xie Yujuan , Ye Zuo-Guang , Zozulya Alexey V. , Sprung Michael , Pietsch Ullrich , Gutt Christian 
Published: July 2018

Significance
The dynamics in many complex systems is essentially heterogeneous and involves a series of discrete events—in particular, local structural changes. The nature and scale of these changes may vary greatly, ranging from rearrangements of atomic positions during phase transitions to displacements of tectonic plates during earthquakes. In this work, we introduce X-ray photon correlation spectroscopy (XPCS) as a powerful tool for investigating heterogeneous dynamics of interfaces. We observe the motion of ferroelectric domain walls by means of XPCS and obtain the information about nanoscale changes, which is inaccessible for other techniques. Further experiments can provide important insights into the mechanisms of unusual properties of materials such as anomalously large piezoelectric response in relaxor-based ferroelectrics and magnetoelectric coupling in multiferroics.
Sword bean variants and different pretreatments influence protein extraction and protein properties
Authors: Nishizawa Kaho , Arii Yasuhiro 
Published: July 2018

ABSTRACT
Two variants of the sword bean (Canavalia gladiata), namely the white sword bean (WSB) and the red sword bean (RSB), are known. The MgCl2 concentration-dependent canavalin solubility showed different behavior among the extracts from distinct beans prepared by distinct pretreatments. Pretreatment and bean selection are important factors for use in food chemical and biochemical experiments.
Temporal indexicals are essential
Authors: Morgan Daniel 
Published: July 2018

Abstract
Are non-indexical action rationalizations necessarily incomplete because of a missing indexical component? Bermúdez (‘Yes, indexicals really are essential’, Analysis 2017) argues that they are. Two things make the argument unpersuasive. First, it assumes that all action rationalizations involve attitudes that are about the agent. Second, it assumes that the attitudes expressible using ‘I’ are themselves indexical. Each is an assumption that believers in complete but non-indexical action rationalizations can and do reject. Surprisingly though, a more effective argument can be obtained by switching focus from indexical attitudes about agents to indexical attitudes about times. The debate about the de se and the de nunc has much less in common than is standardly assumed. It is the de nunc not the de se which provides the knock-down case for essential indexicality.
Gender differences in cognitive performance and health status in the Faroese Septuagenarians cohort
Authors: Petersen Maria Skaalum , Debes Fróði , Grandjean Philippe , Weihe Pál 
Published: July 2018

Abstract
The aim was to determine cognitive performance and health status in the Faroese Septuagenarians cohort in relation to gender differences. In this cross-sectional study of 713 Faroese septuagenarians who underwent a clinical, neurophysiological and neuropsychological examinations and questionnaire, women performed better on tests covering the memory domain, while there was no gender difference in other cognitive domains. Men suffered more frequently from cardiovascular events while women more frequently suffered from arthrosis, hypothyroidism and muscle pain. We observed a considerable heterogeneity and gender difference in some cognitive domains and health in Faroese septuagenarians.
Microprocessor-based prototype bycatch reduction device reduces bait consumption by spiny dogfish and sandbar shark
Authors: Howard Sunkita , Brill Richard , Hepburn Chris , Rock Jenny 
Published: July 2018

Abstract
Elasmobranchs contribute heavily to bycatch in longline fisheries globally, and an effective method of deterring them from baited fishing gear is needed. Electrosensory stimulus holds promise as a method of disrupting elasmobranch close-range feeding responses as their electric sense guides their final strike during prey capture. We used laboratory experiments to test the hypothesis that weak electric stimuli generated by a prototype electronic bycatch reduction device (BRD) could deter sandbar shark (Carcharhinus plumbeus) and spiny dogfish (Squalus acanthias) from eating bait. Voltage gradients &lt;1 mV cm−1 at the location of bait were produced by an Arduino microcontroller powered by a 9 V battery and attached to carbon electrodes. Median bait consumption by groups of juvenile sandbar shark declined by 74% when bait was located 10 cm vs. 2 m from active electrodes. Spiny dogfish median bait consumption halved when bait was located 10 cm from active vs. inactive electrodes. Although laboratory studies often produce a larger effect for electrosensory shark deterrents than can be demonstrated during field trials, if the effects seen in our laboratory studies produced similar effects in the field, it could meet fishermen’s requirements for a BRD.
Regularized HSS iteration methods for stabilized saddle-point problems
Authors: Bai Zhong-Zhi 
Published: July 2018

Abstract
We extend the regularized Hermitian and skew-Hermitian splitting (RHSS) iteration methods for standard saddle-point problems to stabilized saddle-point problems and establish the corresponding unconditional convergence theory for the resulting methods. Besides being used as stationary iterative solvers, this class of RHSS methods can also be used as preconditioners for Krylov subspace methods. It is shown that the eigenvalues of the corresponding preconditioned matrix are clustered at a small number of points in the interval $(0, \, 2)$ when the iteration parameter is close to $0$ and, furthermore, they can be clustered near $0$ and $2$ when the regularization matrix is appropriately chosen. Numerical results on stabilized saddle-point problems arising from finite element discretizations of an optimal boundary control problem and of a Cahn–Hilliard image inpainting problem, as well as from the Gauss–Newton linearization of a nonlinear image restoration problem, show that the RHSS iteration method significantly outperforms the Hermitian and skew-Hermitian splitting iteration method in iteration counts and computing times when they are used either as linear iterative solvers or as matrix splitting preconditioners for Krylov subspace methods, and optimal convergence behavior can be achieved when using inexact variants of the proposed RHSS preconditioners.
SUMO‐specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de‐SUMOylation
Authors: Xiao Ning , Li Hui , Yu Weirong , Gu Chuan , Fang Houshun , Peng Yinbo , Mao Heshui , Fang Yong , Ni Wei , Yao Min 
Published: July 2018

ABSTRACTA key member of the sentrin/small ubiquitin‐like modifier (SUMO)‐specific protease (SENP) family, SENP2 has been shown to implicate embryonic development, fatty acid metabolism, atherosclerosis, and neurodegenerative diseases. However, other biologic functions of SENP2 and its specific targets are incompletely understood. Here, we uncovered a novel role of SENP2 in negative regulation of keratinocyte migration, a process crucial to wound epithelialization. Defects in this function are often associated with the clinical phenotypes of chronic nonhealing wounds. Mechanistically, SENP2 as a specific de‐SUMOylase targets NDR1 (nuclear Dbf2‐related 1), also called STK38 (serine‐threonine kinase 38), for de‐SUMOylation and SUMO conjugation of NDR1 on Lys‐465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2. Significantly, low‐level laser (LLL) irradiation increases NDR1 SUMOylation and subsequent p38/ERK1/2 activation via down‐regulation of SENP2, leading to faster keratinocyte migration. Our findings fill the gaps that linger in the basic mechanisms underlying LLL therapy.—Xiao, N., Li, H., Yu, W., Gu, C., Fang, H., Peng, Y., Mao, H., Fang, Y., Ni, W., Yao, M.SUMO‐specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de‐SUMOylation. FASEB J. 33, 163–174 (2019). www.fasebj.org