bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Ebola experiences and risk perceptions on mental health in Sierra Leone, July 2015
Authors: Jalloh Mohamed F , Li Wenshu , Bunnell Rebecca E , Ethier Kathleen A , O’Leary Ann , Hageman Kathy M , Sengeh Paul , Jalloh Mohammad B , Morgan Oliver , Hersey Sara , Marston Barbara J , Dafae Foday , Redd John T 
Published: March 2018

BackgroundThe mental health impact of the 2014–2016 Ebola epidemic has been described among survivors, family members and healthcare workers, but little is known about its impact on the general population of affected countries. We assessed symptoms of anxiety, depression and post-traumatic stress disorder (PTSD) in the general population in Sierra Leone after over a year of outbreak response.MethodsWe administered a cross-sectional survey in July 2015 to a national sample of 3564 consenting participants selected through multistaged cluster sampling. Symptoms of anxiety and depression were measured by Patient Health Questionnaire-4. PTSD symptoms were measured by six items from the Impact of Events Scale-revised. Relationships among Ebola experience, perceived Ebola threat and mental health symptoms were examined through binary logistic regression.ResultsPrevalence of any anxiety-depression symptom was 48% (95% CI 46.8% to 50.0%), and of any PTSD symptom 76% (95% CI 75.0% to 77.8%). In addition, 6% (95% CI 5.4% to 7.0%) met the clinical cut-off for anxiety-depression, 27% (95% CI 25.8% to 28.8%) met levels of clinical concern for PTSD and 16% (95% CI 14.7% to 17.1%) met levels of probable PTSD diagnosis. Factors associated with higher reporting of any symptoms in bivariate analysis included region of residence, experiences with Ebola and perceived Ebola threat. Knowing someone quarantined for Ebola was independently associated with anxiety-depression (adjusted OR (AOR) 2.3, 95% CI 1.7 to 2.9) and PTSD (AOR 2.095% CI 1.5 to 2.8) symptoms. Perceiving Ebola as a threat was independently associated with anxiety-depression (AOR 1.69 95% CI 1.44 to 1.98) and PTSD (AOR 1.86 95% CI 1.56 to 2.21) symptoms.ConclusionSymptoms of PTSD and anxiety-depression were common after one year of Ebola response; psychosocial support may be needed for people with Ebola-related experiences. Preventing, detecting, and responding to mental health conditions should be an important component of global health security efforts.
Nineteen and Up study (19Up): understanding pathways to mental health disorders in young Australian twins
Authors: Couvy-Duchesne Baptiste , O’Callaghan Victoria , Parker Richard , Mills Natalie , Kirk Katherine M , Scott Jan , Vinkhuyzen Anna , Hermens Daniel F , Lind Penelope A , Davenport Tracey A , Burns Jane M , Connell Melissa , Zietsch Brendan P , Scott James , Wright Margaret J , Medland Sarah E , McGrath John , Martin Nicholas G , Hickie Ian B , Gillespie Nathan A 
Published: March 2018

PurposeThe Nineteen and Up study (19Up) assessed a range of mental health and behavioural problems and associated risk factors in a genetically informative Australian cohort of young adult twins and their non-twin siblings. As such, 19Up enables detailed investigation of genetic and environmental pathways to mental illness and substance misuse within the Brisbane Longitudinal Twin Sample (BLTS).ParticipantsTwins and their non-twin siblings from Queensland, Australia; mostly from European ancestry. Data were collected between 2009 and 2016 on 2773 participants (age range 18–38, 57.8% female, 372 complete monozygotic pairs, 493 dizygotic pairs, 640 non-twin siblings, 403 singleton twins).Findings to dateA structured clinical assessment (Composite International Diagnostic Interview) was used to collect lifetime prevalence of diagnostic statistical manual (4th edition) (DSM-IV) diagnoses of major depressive disorder, (hypo)mania, social anxiety, cannabis use disorder, alcohol use disorder, panic disorder and psychotic symptoms. Here, we further describe the comorbidities and ages of onset for these mental disorders. Notably, two-thirds of the sample reported one or more lifetime mental disorder.In addition, the 19Up study assessed general health, drug use, work activity, education level, personality, migraine/headaches, suicidal thoughts, attention deficit hyperactivity disorder (ADHD) symptomatology, sleep–wake patterns, romantic preferences, friendships, familial environment, stress, anorexia and bulimia as well as baldness, acne, asthma, endometriosis, joint flexibility and internet use.The overlap with previous waves of the BLTS means that 84% of the 19Up participants are genotyped, 36% imaged using multimodal MRI and most have been assessed for psychological symptoms at up to four time points. Furthermore, IQ is available for 57%, parental report of ADHD symptomatology for 100% and electroencephalography for 30%.Future plansThe 19Up study complements a phenotypically rich, longitudinal collection of environmental and psychological risk factors. Future publications will explore hypotheses related to disease onset and development across the waves of the cohort. A follow-up study at 25+years is ongoing.
Impact of a multifactorial treatment programme on clinical outcomes and cardiovascular risk estimates: a retrospective cohort study from a specialised diabetes centre in Denmark
Authors: Safai Narges , Carstensen Bendix , Vestergaard Henrik , Ridderstråle Martin 
Published: March 2018

ObjectivesTo investigate the impact of a multifactorial treatment programme in a real-life setting on clinical outcomes and estimated cardiovascular disease (CVD) risk.DesignA retrospective observational cohort study, using data from the electronic medical records and national registers.SettingTertiary diabetes centre in Denmark.ParticipantsPatients with type 2 diabetes (n=4299) referred to a programme with focus on treatment of hyperglycaemia, hypertension and dyslipidaemia between 1 January 2001 and 1 April 2016.OutcomesPrimary outcomes were changes in haemoglobin A1c (HbA1c), blood pressure (BP) and low-density lipoprotein (LDL) cholesterol as well as proportion reaching treatment targets. Our secondary outcome was to investigate changes in antidiabetic, antihypertensive and lipid-lowering treatment, together with the impact on estimated CVD risk. Linear mixed model for repeated measurements were used for continuous variables and logistic regression for dichotomous variables.ResultsThe patients achieved a mean±SD decrease in HbA1c, systolic and diastolic BP and LDL cholesterol of 1.0%±0.04% (10.6±0.4 mmol/mol), 6.3±0.4 mm Hg, 2.7±0.2 mm Hg and 0.32±0.02 mmol/L, respectively (p<0.0001). The proportion of patients who met the treatment goal for HbA1c(<7% (<53 mmol/mol)) increased from 31% to 58% (p<0.0001); for BP (<130/80 mm Hg) from 24% to 34% (p<0.0001), and for LDL cholesterol (<2.5 mmol/L (patients without previous CVD) or <1.8 mmol/L (patients with previous CVD)) from 52% to 65%. Those reaching all three guideline treatment targets increased from 4% to 15% (p<0.0001), and when relaxing the BP target to <140/85 from 8% to 24%. The estimated CVD risk was relatively reduced by 15.2% using the Swedish National Diabetes Register risk engine and 30.9% using the UK Prospective Diabetes Study risk engine.ConclusionsOur data support that short-term multifactorial treatment of patients with glycaemic dysregulation in a specialist outpatient setting is both achievable and effective, and associated with a clinically meaningful improvement in CVD risk.
Patient navigators facilitating access to primary care: a scoping review
Authors: Peart Annette , Lewis Virginia , Brown Ted , Russell Grant 
Published: March 2018

ObjectivePatient navigators are a promising mechanism to link patients with primary care. While navigators have been used in population health promotion and prevention programmes, their impact on access to primary care is not clear. The aim of this scoping review was to examine the use of patient navigators to facilitate access to primary care and how they were defined and described, their components and the extent to which they were patient centred.Setting and participantsWe used the Arksey and O’Malley scoping review method. Searches were conducted in MEDLINE, Embase, ProQuest Medical, other key databases and grey literature for studies reported in English from January 2000 to April 2016. We defined a patient navigator as a person or process creating a connection or link between a person needing primary care and a primary care provider. Our target population was people without a regular source of, affiliation or connection with primary care. Studies were included if they reported on participants who were connected to primary care by patient navigation and attended or made an appointment with a primary care provider. Data analysis involved descriptive numerical summaries and content analysis.ResultsTwenty studies were included in the final scoping review. Most studies referred to ‘patient navigator’ or ‘navigation’ as the mechanism of connection to primary care. As such, we grouped the components according to Freeman’s nine-principle framework of patient navigation. Seventeen studies included elements of patient-centred care: informed and involved patient, receptive and responsive health professionals and a coordinated, supportive healthcare environment.ConclusionsPatient navigators may assist to connect people requiring primary care to appropriate providers and extend the concept of patient-centred care across different healthcare settings. Navigation requires further study to determine impact and cost-effectiveness and explore the experience of patients and their families.
Assessing the impact of care farms on quality of life and offending: a pilot study among probation service users in England
Authors: Elsey Helen , Farragher Tracey , Tubeuf Sandy , Bragg Rachel , Elings Marjolein , Brennan Cathy , Gold Rochelle , Shickle Darren , Wickramasekera Nyantara , Richardson Zoe , Cade Janet , Murray Jenni 
Published: March 2018

ObjectivesTo assess the feasibility of conducting a cost-effectiveness study of using care farms (CFs) to improve quality of life and reduce reoffending among offenders undertaking community orders (COs). To pilot questionnaires to assess quality of life, connection to nature, lifestyle behaviours, health and social-care use. To assess recruitment and retention at 6 months and feasibility of data linkage to Police National Computer (PNC) reconvictions data and data held by probation services.DesignPilot study using questionnaires to assess quality of life, individually linked to police and probation data.SettingThe pilot study was conducted in three probation service regions in England. Each site included a CF and at least one comparator CO project. CFs are working farms used with a range of clients, including offenders, for therapeutic purposes. The three CFs included one aquaponics and horticulture social enterprise, a religious charity focusing on horticulture and a family-run cattle farm. Comparator projects included sorting secondhand clothes and activities to address alcohol misuse and anger management.ParticipantsWe recruited 134 adults (over 18) serving COs in England, 29% female.Results52% of participants completed follow-up questionnaires. Privatisation of UK probation trusts in 2014 negatively impacted on recruitment and retention. Linkage to PNC data was a more successful means of follow-up, with 90% consenting to access their probation and PNC data. Collection of health and social-care costs and quality-adjusted life year derivation were feasible. Propensity score adjustment provided a viable comparison method despite differences between comparators. We found worse health and higher reoffending risk among CF participants due to allocation of challenging offenders to CFs, making risk of reoffending a confounder.ConclusionsRecruitment would be feasible in a more stable probation environment. Follow-up was challenging; however, assessing reconvictions from PNC data is feasible and a potential primary outcome for future studies.
Don’t neglect the clock drawing test
Authors: Vinker Shuster Michal , Hannah Maayan , Todd Zalut 
Published: March 2018

IntroductionA 63-year-old, right-handed woman with a history of hypertension presented to the ED with left arm paresis of 2 days duration. Three weeks before admission, she had flu-like symptoms with intermittent left arm weakness that had recovered briefly but recurred 2 days prior to her presentation. On neurological examination, GCS was 15 and cranial nerves’ function was normal. Left upper limb strength was 4/5. There was left arm drift and pronation but the patient denied noticing any difference between the positions of her arms. Hyper-reflexion was presented in the left arm. The rest of her motor, cerebellar, sensation and gait functions were normal. She was asked to draw a clock and set it to 15:30 (figure 1).Figure 1Clock drawing test results.Question:What is the most probable aetiology?Right cerebral bleeding involving the occipital lobeRight middle cerebral artery occlusionRight parietal lesion, likely neoplasmLeft cortical stroke
Treating her well
Authors: Theunissen Joris M G , lameijer Heleen 
Published: March 2018

Clinical introductionA 44-year-old woman presents pain free to our ED after experiencing 45 min of tightening of the chest with radiation to her left arm, diaphoresis and nausea. Her vital signs are normal except for her high BP, which is 180/110. She reports recurrent episodes of chest pain in the past 1.5 weeks, unrelated to exercise. She visited a general practitioner who prescribed pain medication and treated her new-onset hypertension. Besides the recently found hypertension, heavy smoking is her only other traditional risk factor for cardiovascular disease.QuestionWhat finding on figure 1 should make you concerned?Figure 1Initial ECG.The U-wave in the precordial leadsThe biphasic P-wave in lead IThe negative T-waves in aVR as well as aVLThe biphasic T-waves in V2 and V3
Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes
Authors: B Schnabel Renate , Pecen Ladislav , Engler Daniel , Lucerna Markus , Sellal Jean Marc , Ojeda Francisco M , De Caterina Raffaele , Kirchhof Paulus 
Published: March 2018

ObjectivesDeterminants of atrial fibrillation (AF) patterns and of progression of earlier forms to permanent AF, and their relationship with outcome are still poorly understood.MethodsWe examined AF patterns (paroxysmal, persistent and permanent), rate and predictors of AF progression, and outcomes in the PREFER (PREvention oF thromboembolic events-European Registry) in AF. The primary analysis was performed in the PREFER in AF prolongation dataset (n=3223 patients with AF with a complete 1-year follow-up, mean age 72±9 years, 40% women). Sensitivity analyses were performed using the PREFER in the AF study (n=6390 patients).ResultsAF progressed to more persistent types in 506 patients (17%). Permanent AF was associated with development of heart failure at 1 year (OR 1.80, 95% CI 1.06 to 3.07, p=0.03) compared with paroxysmal AF, which was confirmed in the entire cohort. In multivariable-adjusted models, sinus rhythm at baseline, AF duration, cardioversion, hyperthyroidism, valvular heart disease, diabetes mellitus and heart failure were predictors of AF progression (area under the receiver operating characteristic curve 0.60, 95% CI 0.57 to 0.63). Results were similar when we restricted analyses to patients with AF duration <1 year. AF progression showed an association with coronary events over 1 year (OR 2.27, 95% CI 1.22 to 4.19, p=0.0074).ConclusionsPermanent AF at baseline was associated with incident heart failure. A substantial proportion of well-managed patients with AF showed AF progression over 1 year. AF progression itself was not strongly related to outcome and may indicate the need to refine the current classification of AF types to enhance clinical utility.
Quantification of energy expenditure of military loaded runs: what is the performance of laboratory-based equations when applied to the field environment?
Authors: Colosio Alessandro L , Pogliaghi S 
Published: March 2018

IntroductionPerformance during army loaded runs provides a synthetic indicator of a soldier’s capacity to move while carrying loads and thereby remain able to execute a mission. The aim of this study was to estimate and compare the energy expenditure (EE) of army loaded runs, conducted in a field environment using laboratory-based equations and HR index (HRindex).Methods45 Ranger recruits had HR monitored during three loaded runs (10, 15 and 20 km) in full military equipment in the field environment. EE was calculated using reference equations (EE-Eq) and estimates of oxygen consumption based on HRindex(EE-HRindex). Correspondence between EE-Eq and EE-HRindexestimates was evaluated using a two-way analysis of variance, correlation test and Bland-Altman analysis.ResultsEE-Eq relative to time and weight was significantly higher for the 10 km (0.175±0.016) compared with 15 and 20 km (0.163±0.016 and 0.160±0.013 kcal/kg/min, not different). The overall EE-Eq increased significantly with distance (1129±59, 1703±80 and 2250±115 kcal for 10, 15 and 20 km). EE-Eq was not different from and highly correlated with EE-HRindex, with a small and non-significant bias and good precision between methods.ConclusionsOur study provides the first comprehensive data on HR and EE during long-distance loaded army runs, in full combat equipment, in actual field conditions. Equation-based estimates of EE during these heavy-intensity activities were not significantly different from and highly correlated with HR-based estimates. This corroborates the general applicability of the predictive equations in the field environment. Furthermore, our study suggests that time-resolved HR-based estimates of EE during army runs can be used to evaluate for the effects of context specificity, individual variability and fatigue in movement economy.
Medical and surgical management of intraspecific wounds in a European beaver kit (Castor fiber)
Authors: O’Brien Michelle F , Meldrum Julia , Foster Ian 
Published: March 2018

A captive European beaver (Castor fiber) kit, of approximately eight to ten weeks of age, was found in his enclosure with multiple wounds caused by intraspecific aggression. Six wounds healed quickly, while three progressed to abscessation. Severe proprioceptive deficits developed in both hindlegs as a secondary complication. A number of different antibiotics, general anaesthesia and basic physiotherapy (including range‐of‐motion exercises and hydrotherapy) were used in conjunction to treat these wounds over the following 10 months. Anti‐inflammatories were used as needed. Bacteria cultured from the infected wounds included Enterobacter cloacae, Serratia marcescens, Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia liquefaciens and Stenotrophomonas maltophilia. This report presents previously unreported information regarding the use and effectiveness of various medications and physiotherapy techniques in juvenile European beavers.
Empirically Testing Factors Increasing Manufacturing Product Innovation Success
Authors: Guimaraes Tor , Paranjape Ketan , Cornick Mike , Armstrong Curtis P. 
Published: March 2018

Purpose: Important determinants of new product development success fall into five main areas encompassing strategic leadership, competitive intelligence, management of technology, specific characteristics of the company's innovation process, and the company's absorptive capacity to use available knowledge to produce and commercialize new products. Unfortunately the existing knowledge on each of these five areas is not being shared by researchers in the other areas, thus the models are focused on the particular research area. This study tests these constructs as a set of determinants of product innovation success.Design/methodology/approach: A field test using a mailed questionnaire to collect a relatively large sample of manufacturing companies has been used to test the proposed model. To eliminate possible multicollinearity among the independent variables, a multivariate regression analysis was used.Findings: The results provide clear evidence about the importance of competitive intelligence, strategic leadership, competitive intelligence, management of technology, specific characteristics of the company's innovation process, and company absorptive capacity with company success in new product development.Research limitation/implications: Despite the relatively broad scope of the proposed model, other factors may also be important and should be included in future studies.Practical implications: The items used for measuring the main constructs provide further and more specific insights into how managers should go about developing these areas within their organizations.Originality/value: While the study is grounded in the literature of what until now have been five separate areas of knowledge, it proposed a unique integrated model for these areas important to new product development.
A Paleozoic-sourced oil play in the Jura Mountains of France and Switzerland
Authors: Pullan C. P. , Berry M. 
Published: March 2018

Abstract
The Jura region of France and Switzerland has significant hydrocarbon potential. This arcuate fold-and-thrust belt, located in front of the Western Alps, is composed of Mesozoic rocks, which overlie the North Swiss Basin Complex filled with Permo-Carboniferous sediments of Late Westphalian–Lower Permian (Autunian) age. The existence of three small producing gas fields, and the presence of recorded oil and gas shows in a number of petroleum wells, indicate the presence of an active petroleum system. Shows occur in stratigraphic horizons that lie beneath the regional Triassic evaporite seal. Very effective Permo-Carboniferous oil-prone source rocks include algal organically rich Autunian shale beds and Stephanian-aged bituminous shales. Carboniferous and Permian coals are also present, which would be excellent sources of gas. The primary reservoir target is the fluviatile Triassic Bunter Sandstone Formation, which is widely developed across the area and thickens to the NE. Reservoir quality is best developed in the cleaner channel sands. The La Chandelière oil field, discovered in 1989 by Exxon, is crucial evidence of the oil potential and trapping mechanism. Geochemical analysis demonstrates that the 41° API oil at La Chandelière is derived from Lower Permian Autunian shales. The trapping mechanism, interpreted from seismic and confirmed by structural modelling, is that of an unreactivated Mesozoic-aged structural high bounded by thrust faults, resulting in a large-scale rollover within the core of the structure. This combination of critical elements sets up the Paleozoic-sourced oil play within the Jura Mountains of France and Switzerland.
The Jura is not generally regarded as a major petroleum province. It is a region of complex structuring and mountainous terrain. Switzerland, a country renowned for its beautiful mountain scenery, has no major oil and gas discoveries. However, this poorly explored region has active petroleum systems with good hydrocarbon shows and a number of small gas fields demonstrating hydrocarbon generation. Good-quality source rocks and excellent reservoir development have been proven by drilling, and seismic interpretation has demonstrated the existence of large closures at reservoir level. The La Chandelière oil discovery, in the French Jura, proves the presence of a Paleozoic-sourced oil play.