bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of landscape complexity and stand factors on arthropod communities in poplar forests
Authors: Wang Binli , Tian Chengming , Sun Jianlong 
Published: June 2019

AbstractThe arthropod communities are influenced by both local conditions and features of the surrounding landscape. Landscape complexity and stand factors may both influence arthropod communities in poplar forests, but the multiscale effects of these factors on poplar defoliators and natural enemies are still poorly understood. We collected poplar arthropods at 30 sampling sites within five forest landscapes in Xinjiang, China, and assessed whether landscape complexity and stand factors influence species abundance and diversity of poplar arthropods. Landscape complexity was quantified by several independent metrics of landscape composition, configuration, and connectivity at three spatial scales. We also determined the most powerful explanatory variables and the scale effect of each arthropod. Results found that landscape complexity and stand factors had different effects on different poplar arthropod communities. Landscape complexity promoted natural enemies at different spatial scales, but it inhibited the population of poplar defoliators at the scale of 200 m. Specifically, the abundance and diversity of all defoliators decreased with increasing proportion of nonhost plants. Landscape diversity only had a negative effect on defoliator abundance. The shape complexity of habitat patches increased the abundance of carabid beetles but reduced the abundance of green leafhoppers and migratory locusts. The abundance and diversity of predators increased with increasing structural connectivity of forest landscape. Additionally, both the abundance and diversity of all defoliators were positively correlated with the average height of herbaceous plants. Diversity of all defoliators increased with increasing size of host trees. The distance from sampling site to the nearest village positively influenced the abundance and diversity of all predators. Arthropod abundance and diversity in poplar forests were driven by stand factors and landscape complexity. Therefore, maintaining complex shape and structural connectivity of habitat patches and keeping poplar stands away from the village are crucial for management of forest landscape to enhance natural enemies. And in order to reduce the abundance of defoliators in poplar forest, the diversity of surrounding habitat types should be promoted within 200 m radii.
Ecosystem‐scale loss of grazing habitat impacted by abundance of dominant herbivores
Authors: Uher‐Koch Brian D. , Schmutz Joel A. , Wilson Heather M. , Anthony R. Michael , Day Thomas L. , Fondell Thomas F. , Person Brian T. , Sedinger James S. 
Published: June 2019

AbstractGrazing lawns, patches of grazing‐tolerant plants with high nutrient value, provide important habitat for herbivores, and changes in abundance can impact herbivore populations. Grazing lawns are maintained in quality and quantity by repeated grazing and are a result of a positive feedback since the availability of grazing lawn can increase herbivore populations and increased herbivore populations can result in an increase in grazing lawn extent. We sampled aerial imagery from a long‐term dataset (>20 yr) at an internationally important breeding area for avian herbivores to model changes in grazing lawn abundance over time and identify the possible factors impacting those changes, including numbers of breeding birds, their primary predator, and spring phenology. Our data suggest that avian herbivores and their predators likely exert strong impacts on plant communities and may drive vegetation abundance. Decreases in the number of herbivore nests in our study coincided with an almost complete lack of grazing lawn in the mid‐2000s. Any factors dictating the amount of grazing lawn available for avian herbivores could strongly influence breeding success and the maximum size of these populations. Our results demonstrate the importance of studying complex interactions among predators, herbivores, and plants, and population moderation by both bottom‐up and top‐down processes.
Forest closure and encroachment at the grassland interface: a century‐scale analysis using oblique repeat photography
Authors: Stockdale Christopher A. , Macdonald S. Ellen , Higgs Eric 
Published: June 2019

AbstractWe used repeat oblique photography to quantify and determine the drivers of vegetation change, particularly forest closure and encroachment, in the Rocky Mountains of southern Alberta, Canada, from the beginning of the twentieth century to the present. We classified the landscape into seven distinct vegetation types (closed‐canopy conifer forest, broadleaf deciduous forest, mixedwood forest, open‐canopy woodlands, shrublands, grasslands and meadows, non‐vegetated) and assessed vegetation change between the two time periods. We found that closed‐canopy coniferous forest, broadleaf deciduous forest, and mixedwood forest increased on an area basis by 35%, 45%, and 80%, respectively, over this time period; concomitantly, grasslands and open‐canopy woodlands declined by 25% and 39%, respectively. Overall, 28% of the landscape was in a more advanced successional state in 2008 as compared to the early twentieth century. The Montane and Subalpine Natural Subregions (NSR) experienced the most change (42% and 26%, respectively, in a more advanced successional state). The loss of open‐canopy woodlands was observed across the entire landscape, while grassland and meadow losses were most acute in the Subalpine and Alpine NSRs. The probability of vegetation change to a more advanced successional condition was greater at higher elevations and in areas receiving lower amounts of solar insolation. The changes observed are consistent with what we would expect to see due to lengthening of fire return intervals. Understanding the magnitude of change in vegetation types and the drivers of this change is important for the development of effective contemporary ecosystem management and restoration practices.
Forests in the northern Sierra Nevada of California, USA, store large amounts of carbon in different patterns
Authors: Mattson Kim G. , Zhang Jianwei 
Published: June 2019

AbstractTo better understand forest carbon (C) storage patterns, C budgets were constructed and contrasted among four stands of different vegetation, elevation, and disturbance histories from the northern Sierra Nevada of California, USA. The True‐fir stand, considered to be undisturbed and at a higher elevation (1820 m), stored substantially more C than the three stands at lower elevation (1360–1430 m) and that had sustained various levels of disturbance. The Mixed Conifer stand was minimally disturbed by thinning 27 yr ago. The Oak stand was moderately disturbed by two fires in the past 17 yr. The Pine Plantation stand was considered the most disturbed having been cleared and subjected to site preparation and windrowing 50 yr ago and thinned again 17 yr ago. Total C mass to a 30 cm soil depth (Mg C/ha) was True‐fir 531, Mixed Conifer 317, Oak 310, and Pine Plantation 253. Adding in soil C to 1 m depth increased total C mass to 595, 349, 404, and 345, respectively. True‐fir had significantly larger C mass than the other three stands in nearly all pools measured. The three low‐elevation stands, while similar to each other in total C, stored C differently in patterns that reflected their disturbance histories. Oak and Pine Plantation were very similar in detrital C stores, whereas Mixed Conifer had at least twice the C mass in both the forest floor and woody debris pools. Mixed Conifer had higher concentrations of soil C but had very low soil C mass due to considerably lower fine‐soil bulk densities and higher rock contents. C pools in the forest floor and soil showed observable patterns over distances of 10–100 m that paralleled the patterns of C in the live vegetation. Total C in True‐fir was equal to the large masses of old‐growth conifer forests of the U.S. Pacific Northwest and likely represents a high‐equilibrium level of C storage for forests of this region. The three low‐elevation stands represent typical forests in various states of recovery from disturbance that are in C accumulating stages.
Electrochemical Sensor Based on Multi‐walled Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrode for Detection of Estradiol in Environmental Samples
Authors: Masikini Milua , Ghica Mariana Emilia , Baker Priscilla G. L. , Iwuoha Emmanuel I. , Brett Christopher M. A. 
Published: June 2019

AbstractWe report a rapid and simple method for sensing estradiol by electro‐oxidation on a multi‐walled carbon nanotube (MWCNT) and gold nanoparticle (AuNP) modified glassy carbon electrode (GCE). Compared with a bare GCE, AuNP/GCE and MWCNT/GCE, the composite modified GCE shows an enhanced response to estradiol in 0.1 M phosphate buffer solution. Experimental parameters, including pH and accumulation time for estradiol determination were optimised at AuNP/MWCNT/GCE. A pH of 7.0 was found to be optimum pH with an accumulation time of 5 minutes. Estradiol was determined by linear sweep voltammetry over a dynamic range up to 20 %mol L−1 and the limit of detection was estimated to be 7.0×10−8 mol L−1. The sensor was successfully applied to estradiol determination in tap water and waste water.
Effect of storage temperature on lipid oxidation and changes in nutrient contents in peanuts
Authors: Liu Kunlun , Liu Ying , Chen Fusheng 
Published: June 2019

AbstractPeanut, an important oil crop worldwide, is highly susceptible to oxidative damage during storage due to its high level of fats and unsaturated fatty acids which will affects its nutritional value and agricultural importance. Therefore, it is significantly important to research the physicochemical properties changes of peanuts during storage. Peanuts belong to two varieties were stored at various temperatures (15°C, 25°C, and 35°C) for 320 days. Peroxide value (PV), carbonyl value (CV), and malondialdehyde (MDA) content of oil extracted from peanuts were determined every 80 days to evaluate lipid oxidation degree. Proximate composition (fat, protein, total sugar, moisture, and ash), fatty acid, and amino acid compositions were also assessed. All samples exhibited increased CV and MDA contents during storage. The PV of peanuts increased continuously when stored at 15°C and 25°C, but the PV increased firstly and then decreased sharply when stored at 35°C. Storage significantly affected the contents of lipids, proteins, total sugars, and moisture in peanuts but did not influence the ash content. In general, the fatty acid and amino acid compositions changed significantly during storage at different temperatures. High temperatures lead to a high degree of lipid oxidation and nutrient loss. The results above of this study can provide a theoretical basis for the actual storage and preservation of peanuts.
Hydrometeorological measurements in peatland‐dominated, discontinuous permafrost at Scotty Creek, Northwest Territories, Canada
Authors: Haynes Kristine M. , Connon Ryan F. , Quinton William L. 
Published: June 2019

AbstractThe discontinuous permafrost region of northwestern Canada is experiencing rapid warming resulting in dramatic land cover change from forested peatland permafrost terrain to treeless wetlands. Extensive research has been conducted throughout this region to gain insight into how climate‐induced land cover change will impact water resources and ecosystem function. This paper presents a hydrological and micrometeorological dataset collected in the Scotty Creek basin, Northwest Territories, Canada over the period of 01 October 2014 to 30 September 2015, a sample of the intensive and coordinated measurements collected annually at this site. Micrometeorological data collected from four stations, one located in each of the land cover types representative of those comprising the Scotty Creek basin including bog, channel fen, stable peat plateau and peat plateau undergoing rapid permafrost degradation and loss, are presented. Monitored micrometeorological variables include incoming and outgoing shortwave and longwave radiation, air temperature, relative humidity, wind speed, precipitation (rain and snow) and snow depth. Deep ground temperatures (~1–10 m below the ground surface) from a channel fen as well as disturbed sites common to the basin including a seismic line and winter road are presented. Water levels were also monitored in the representative land cover types over this period. This dataset is available from the Wilfrid Laurier University Library Research Data Repository (https://doi.org/10.5683/SP/OQDRJG) and can be used in coordination with other hydrological and micrometeorological datasets to examine spatio‐temporal effects of meteorological conditions on local hydrological responses across cold regions.
Abnormalities of hippocampal shape and subfield volumes in medication‐free patients with obsessive–compulsive disorder
Authors: Zhang Lianqing , Hu Xinyu , Lu Lu , Li Bin , Hu Xiaoxiao , Bu Xuan , Li Hailong , Tang Shi , Yang Yanchun , Roberts Neil , Sweeney John A. , Gong Qiyong , Huang Xiaoqi 
Published: June 2019

AbstractIn this study, we sought to identify alterations of hippocampal shape and subfield volumes in a relatively large sample of medication‐free obsessive–compulsive disorder (OCD) patients without comorbid depression. 3D T1‐weighted Magnetic Resonance Imaging scans were collected from 81 medication‐free OCD patients and 95 age‐ and sex‐matched healthy controls (HC). Total hippocampal volume and volume of eight bilateral subfields were measured using FreeSurfer software. Subregional shape deformity was examined via FSL software. Volumetric and shape differences between groups and correlations with OCD symptoms were examined. The volume of right hippocampus was significantly reduced in OCD patients (p = .001, η2 = 0.065). Follow‐up analysis of right hemisphere subfields showed reduced volume in right subiculum (p < .001, η2 = 0.081), presubiculum (p < .001, η2 = 0.125), CA2/3 (p = .001, η2 = 0.06), and hippocampal tail (p < 0.001, η2 = 0.105), while the volume of right fimbria was increased (p = .001, η2 = 0.058). Shape analysis revealed a bilateral outward bending in the hippocampal body related to a lateral displacement of hippocampus from the body to the tail. Symptom severity was correlated with volumes of presubiculum (with compulsions, r = −0.25, p = .024) and fimbria (with obsessions, r = −0.28, p = .012), and with the lateral shift of middle and posterior hippocampus (with obsessions). Alterations across hippocampal subfields and overall shape may contribute to the distinctive cognitive and affective abnormalities associated with OCD.
Network spread determines severity of degeneration and disconnection in Huntington's disease
Authors: Poudel Govinda R. , Harding Ian H. , Egan Gary F. , Georgiou‐Karistianis Nellie 
Published: June 2019

AbstractTrans‐neuronal propagation of mutant huntingtin protein contributes to the organised spread of cortico‐striatal degeneration and disconnection in Huntington's disease (HD). We investigated whether the network diffusion model, which models transneuronal spread as diffusion of pathological proteins via the brain connectome, can determine the severity of neural degeneration and disconnection in HD. We used structural magnetic resonance imaging (MRI) and high‐angular resolution diffusion weighted imaging (DWI) data from symptomatic Huntington's disease (HD) (N = 26) and age‐matched healthy controls (N = 26) to measure neural degeneration and disconnection in HD. The network diffusion model was used to test whether disease spread, via the human brain connectome, is a viable mechanism to explain the distribution of pathology across the brain. We found that an eigenmode identified in the healthy human brain connectome Laplacian matrix, accurately predicts the cortico‐striatal spatial pattern of degeneration in HD. Furthermore, the spread of neural degeneration from sub‐cortical brain regions, including the accumbens and thalamus, generates a spatial pattern which represents the typical neurodegenerative characteristics in HD. The white matter connections connecting the nodes with the highest amount of disease factors, when diffusion based disease spread is initiated from the striatum, were found to be most vulnerable to disconnection in HD. These findings suggest that trans‐neuronal diffusion of mutant huntingtin protein across the human brain connectome may explain the pattern of gray matter degeneration and white matter disconnection that are hallmarks of HD.
CAR T‐cell therapy: Full speed ahead
Authors: Sermer David , Brentjens Renier 
Published: June 2019

AbstractChimeric antigen receptor (CAR) T‐cell therapy has dramatically shifted the landscape of treatment for lymphoid malignancies, especially diffuse large B‐cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL). However, there continue to be significant limitations of this therapy, such as incomplete or nonsustained responses and severe toxicities in a subset of patients. Furthermore, expanding the role of CAR T‐cell therapy to new disease types is an important next step. In this review, we will highlight landmark trials for anti‐CD19 CAR T cells and first‐in‐human trials of novel CARs, as well as discuss promising innovative CAR designs that are still undergoing preclinical development. Lastly, we will discuss toxicity and mechanisms of CAR T‐cell resistance and failure, as well as potential future treatment approaches to these common issues.
New drugs for old targets
Authors: Salles Gilles 
Published: June 2019

AbstractIn recent years, many new antibodies, either naked or armed with toxin or radionuclides have been investigated to enhance the field of active agents directed against already identified (“old”) targets. This was particularly the case for the antigens CD19 and CD20 but also some other ones. The success of these developments has been variable and underlines the need to better characterize the mode of action of these molecules. Combinations studies of these new agents with other molecules, in particular those with an immunomodulatory potential, are also currently developed with some promising results.
Impact of HOTAIR variants on preeclampsia susceptibility based on blood and placenta and in silico analysis
Authors: Mohammadpour‐Gharehbagh Abbas , Jahantigh Danial , Saravani Mohsen , Harati‐Sadegh Mahdiyeh , Maruie‐Milan Rostam , Teimoori Batool , Salimi Saeedeh 
Published: June 2019

AbstractHOX transcript antisense RNA (HOTAIR) as a lncRNA involves in epigenetic regulation of various genes. Several studies have been suggested the effects of HOTAIR polymorphisms on different diseases. The aim of the present study was to evaluate the effect of maternal and placental HOTAIR polymorphisms on risk of preeclampsia (PE). The maternal blood of 203 preeclamptic and 202 nonpreeclamptic pregnant women as well as the placentas of 87 of preeclamptic and 95 nonpreeclamptic pregnant women were genotyped for HOTAIR polymorphisms. There was no association between maternal and placental HOTAIR polymorphisms (rs12826786, rs920778, and rs1899663) and PE risk. However, the maternal rs4759314AG and dominant model genotypes were associated with increased risk of PE. The maternal and placental HOTAIR rs10783618 polymorphism was associated with PE risk in recessive and allelic models. Haplotype analysis showed that, the maternal CTGAT and CCTAT and placental CTGAT haplotypes were significantly higher and maternal CTGAC, TCTAT, and TTGAT and placental CTGAC haplotypes were significantly lower in PE women. In silico analysis revealed that HOTAIR rs1899663 had a main effect on the secondary structure of mRNA, however, HOTAIR rs4759314 variant had potential alteration of splicing. In conclusion, the maternal and placental HOTAIR rs10783618 polymorphism might increase PE susceptibility. © 2019 IUBMB Life, 71(9):1367–1381, 2019
Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent
Authors: Khurana Kanupriya , Guillem‐Marti Jordi , Soldera Flavio , Mücklich Frank , Canal Cristina , Ginebra Maria‐Pau 
Published: June 2019

AbstractApatitic bone cements have been used as a clinical bone substitutes and drug delivery vehicles for therapeutic agents in orthopedic applications. This has led to their combination with different drugs with known ability to foster bone formation. Recent studies have evaluated Simvastatin for its role in enhanced bone regeneration, but its lipophilicity hampers incorporation and release to and from the bone graft. In this study, injectable calcium phosphate foams (i‐CPF) based on α‐tricalcium phosphate were loaded for the first time with Pitavastatin. The stability of the drug in different conditions relevant to this study, the effect of the drug on the i‐CPFs properties, the release profile, and the in vitro biological performance with regard to mineralization and vascularization were investigated. Pitavastatin did not cause any changes in neither the micro nor the macro structure of the i‐CPFs, which retained their biomimetic features. PITA‐loaded i‐CPFs showed a dose‐dependent drug release, with early stage release kinetics clearly affected by the evolving microstructure due to the setting of cement. in vitro studies showed dose‐dependent enhancement of mineralization and vascularization. Our findings contribute towards the design of controlled release with low drug dosing bone grafts: i‐CPFs loaded with PITA as osteogenic and angiogenic agent.
The Effect of 1 Year of Romosozumab on the Incidence of Clinical Vertebral Fractures in Postmenopausal Women With Osteoporosis: Results From the FRAME Study
Authors: Geusens Piet , Oates Mary , Miyauchi Akimitsu , Adachi Jonathan D , Lazaretti‐Castro Marise , Ebeling Peter R , Perez Niño Carlos Augusto , Milmont Cassandra E , Grauer Andreas , Libanati Cesar 
Published: June 2019

ABSTRACTRadiographic vertebral fractures (VFxs) are the most common fractures in osteoporosis and are associated with increased morbidity, mortality, and costs. A subset of VFxs manifest clinically, usually with a sudden onset of severe back pain. Romosozumab is a monoclonal antibody that binds and inhibits sclerostin, increasing bone formation and decreasing bone resorption, leading to rapid and large increases in bone density and strength and reduction in fracture risk. The FRAME (Fracture Study in Postmenopausal Women with Osteoporosis) study of postmenopausal women with osteoporosis demonstrated a significant reduction in new VFxs with romosozumab versus placebo. Here, we report the effect of romosozumab versus placebo on clinical VFx incidence over 12 months in women reporting back pain suggestive of VFxs. FRAME enrolled 7180 postmenopausal women with osteoporosis, mean age 70.9 years (hip T‐score −2.5 to −3.5). In the first year of the study, women received monthly romosozumab 210 mg (n = 3589) or placebo (n = 3591). At regular monthly visits, women reporting back pain suggestive of a clinical VFx had a confirmatory spine X‐ray. Clinical VFx risk in the romosozumab group versus the placebo group was calculated by Cox‐proportional hazards model. Of 119 women in FRAME with back pain suggestive of a clinical VFx over 12 months, 20 were confirmed to have experienced a new/worsening VFx. Three women receiving romosozumab had a clinical VFx (<0.1% of 3589 women) versus 17 (0.5% of 3591 women) receiving placebo resulting in a reduction in clinical VFx risk of 83% in the romosozumab group versus placebo through 12 months (HR 0.17; 95% CI, 0.05 to 0.58; p = 0.001). In the three romosozumab‐treated women, clinical VFxs occurred within the first 2 months of the study with no further clinical VFxs throughout the year. Romosozumab treatment for 12 months was associated with rapid and large reductions in clinical VFx risk versus placebo. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.