bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and pharmacokinetics of vepdegestrant in Japanese patients with ER+ advanced breast cancer: a phase 1 study
Authors: Iwata Hiroji , Naito Yoichi , Hattori Masaya , Yoshimura Akiyo , Yonemori Kan , Aizawa Mana , Mori Yuko , Yoshimitsu Junichiro , Umeyama Yoshiko , Mukohara Toru 
Published: November 2024

Abstract
Background
Vepdegestrant (ARV-471) is an oral PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader.

Methods
This phase 1 study (NCT05463952) investigated safety, pharmacokinetics, and antitumor activity of vepdegestrant in Japanese patients with ER-positive (ER+)/human epidermal growth factor receptor 2–negative (HER2-) advanced breast cancer at the 200-mg once daily (QD) recommended phase 3 dose. Eligible patients had ER+/HER2- advanced breast cancer resistant to standard therapy, with no standard therapy available, or had received two or more prior endocrine therapies in any setting. The primary endpoint was dose-limiting toxicities (DLTs) in cycle 1; secondary endpoints included safety, pharmacokinetics, and antitumor activity.

Results
Six female patients (median age, 58 [range: 47–62] years) were treated. For advanced disease, three (50.0%) patients received three or more prior regimens and five (83.3%) patients received prior cyclin-dependent kinase 4/6 inhibitors. At data cutoff, median treatment duration was 9.8 (range: 6–28) weeks; two patients remained on treatment. No DLTs were observed. Four (66.7%) patients experienced adverse events; none led to dose reduction or discontinuation. Four (66.7%) patients had treatment-related adverse events; all were grade 1 except anemia (grade 2). Geometric mean maximum plasma concentration and 24-h area under the plasma concentration–time curve of vepdegestrant were 630.9 ng/mL and 10,400 ng∙hr/mL after a single dose and 1056 ng/mL and 18,310 ng∙hr/mL after multiple doses. Two (33.3%) patients demonstrated stable disease at week 24.

Conclusion
Vepdegestrant 200 mg QD was well tolerated in Japanese patients with ER+/HER2- advanced breast cancer with no notable differences in pharmacokinetics from Western patients.

Clinical trial registration
ClinicalTrials.gov: NCT05463952 (date of registration: July 19, 2022).
Blood ammonia concentration measurement – effects of sampling site and cirrhosis during induced hyperammonaemia
Authors: Djernes Lars , Vilstrup Hendrik , Ott Peter , Eriksen Peter Lykke 
Published: November 2024

Abstract

Background
Ammonia is implicated in hepatic encephalopathy (HE) and prognostic in cirrhosis. Venous ammonia concentration, yielding similar correlation with HE grades as arterial, has become the preferred practise but comparative data are limited.

Aim
To quantify effect of sampling site on ammonia concentration in healthy persons and patients with cirrhosis.

Methods
Ammonia concentrations were measured by arterial and femoral venous blood sampling in ten healthy men and ten male patients with cirrhosis before and during hyperammonaemia induced by ammonia infusion. Cubital vein samples were included during the infusion.

Results
At baseline, arterial-venous concentration gaps were similar (p = 0.15) in healthy persons [14 (10–19) and 8 (4–12) µmol/L] and patients with cirrhosis [53 (32–74) and 40 (23–57) µmol/L]. Ammonia infusion increased arterial-venous concentration gaps in both groups [115 (97–133) and 61 (31–90) vs. 175 (123–227) and 134 (65–203) µmol/L]. Mean ammonia concentration difference between groups during hyperammonaemia was 72 (42–103) µmol/L (p < 0.001) and independent of sampling site. Cubital and femoral vein concentrations were comparable (p = 0.26). In cirrhosis, calculated upper limit normal values (ULN) were comparable for arterial and venous blood at baseline [2.0 (1.2–2.8) and 2.1 (1.2–3.0), p = 0.74] and during hyperammonaemia [6.7 (4.7–8.7) and 6.2 (4.4– 8.1), p = 0.44].

Conclusions
We found clinically meaningful intra-individual arterial-venous concentration gaps in both healthy persons and patients with cirrhosis at any ammonia concentration. Inter-group concentration differences after induced hyperammonaemia were relatively constant across sampling sites which supports clinical use of venous sampling. ULN-normalised ammonia concentrations were valid for both arterial and venous sampling.
Fluorine/bromine/selenium multi-heteroatoms substituted dual-asymmetric electron acceptors for o-xylene processed organic solar cells with 19.12% efficiency
Authors: Zhou Yibo , Qi Guangyu , Liu Han , Bai Hairui , Li Tengfei , Maqsood Muhammad Hamza , Liu Chang , Song Bohao , Chen Na , Lu Guanghao , Gao Chao , Liu Yuhang , Su Wenyan , Du Huiling , Ma Ruijie , Ma Wei , Fan Qunping 
Published: November 2024

AbstractThe development of high-performance near-infrared (NIR) absorbing electron acceptors is a major challenge in achieving high short-circuit current density (JSC) to increase power conversion efficiency (PCE) of organic solar cells (OSCs). Herein, three new multi-heteroatomized Y-series acceptors (bi-asy-Y-Br, bi-asy-Y-FBr, and bi-asy-Y-FBrF) were developed by combining dual-asymmetric selenium-fused core and brominated end-groups with different numbers of fluorine substitutions. With gradually increasing fluorination, three acceptors exhibit red-shift absorption. Among them, bi-asy-Y-FBrF presents planar molecular geometry, the maximum average electrostatic potential, and the minimum molecular dipole moment, which are conducive to intramolecular packing and charge transport. Moreover, D18:bi-asy-Y-FBrF active layer presents higher crystallinity, more suitable phase separation, and reduced charge recombination compared to D18:bi-asy-Y-Br and D18:bi-asy-Y-FBr blends. Consequently, among theses binary OSCs, D18:bi-asy-Y-FBrF device achieves a higher PCE of 15.74% with an enhanced JSC of 26.28 mA cm−2, while D18:bi-asy-Y-Br device obtains a moderate PCE of 15.04% with the highest open-circuit voltage (VOC) of 0.926 V. Inspired by its high VOC and complementary absorption with NIR-absorbing BTP-eC9 as acceptor, bi-asy-Y-Br is introduced into binary D18:BTP-eC9 to construct ternary OSCs, achieving a further boosted PCE of 19.12%, which is among the top values for the reported green solvent processed OSCs.
Integrating Circular Economy Principles in the Electric Motor Industry: A Comprehensive Framework and Case Study for Sustainable Supply Chain Management
Authors: de Souza Andrade Guilherme , Pereira M. Teresa , Pinto Viviana Correia , Campos Lucila Maria , Fonseca Luis Miguel 
Published: November 2024

AbstractThis study develops and validates an innovative assessment framework designed to integrate circular economy principles into the operations and supply chain of the electric motor industry. Given the rising demand for electric motors across various sectors, effective end-of-life management has become critical for enhancing sustainability. The primary objective of the proposed framework is to create a holistic approach that improves motor sustainability by addressing all stages of the product life cycle, from material sourcing and production to utilization and end-of-life management. The study employs a case study methodology, focusing on an electric motor company, to validate the framework’s applicability and effectiveness. Key findings reveal that emphasizing motor recovery significantly prolongs product lifecycles, reducing waste and conserving resources. The framework’s adaptability suggests its potential application across various business contexts, though it requires customization to fit specific production, logistics, and resource allocation needs. Recommendations include further research to refine the framework for other industries and the potential for policy changes that support circular economy practices. The article provides practical insights into overcoming barriers to CE adoption, emphasizing the need for strategic management capabilities, policy support, and industry-specific customization. This comprehensive approach not only addresses current sustainability challenges within the electric motor industry but also serves as a model for other sectors seeking to implement circular economy principles.
What are the priority welfare issues facing parrots in captivity? A modified Delphi approach to establish expert consensus
Authors: Chalmers Rhianne , Cooper Jonathan , Ventura Beth 
Published: November 2024

Abstract
Parrots (Psittaciformes) are widely kept in captivity, yet their welfare is under-researched in comparison to other captive species. This study aimed to determine key welfare issues affecting parrots through a modified Delphi approach. Twenty-eight welfare issues were first compiled via a preliminary literature review. Parrot welfare experts and sector professionals (n = 26) were then recruited to participate in an online survey to rank the identified welfare issues on a six-point scale according to severity, duration and prevalence of each issue. Participants could provide commentary on their ranking and propose additional welfare issues of concern. Items with a mean score of 4 or above progressed to a second survey, where participants (n = 14) indicated whether they agreed or disagreed with the current ranking of the welfare issue. Finally, two online workshops were held, where participants (n = 7) discussed the rankings from the second survey and sought to establish a consensus on the top ten welfare issues in each category and overall. Six of the seven final participants agreed with the final rankings, achieving a consensus rate of 86%. The top welfare issues overall were lack of owner knowledge and support; social isolation; housing; environmental opportunity to express behaviours; nutrition; development of normal behaviour; lack of a ‘life plan’ for birds; abnormal behaviours; lack of parrot-specific veterinary training; and insufficient application and enforcement of legislation. It is hoped that identification and recognition of these priority areas will be useful in directing future efforts in research, owner and veterinary education, and policy initiatives to improve parrot welfare.
Uniformity aspects of
${\mathrm {SL}}(2,{\mathbb R})$
cocycles and applications to Schrödinger operators defined over Boshernitzan subshifts
Authors: DAMANIK DAVID , LENZ DANIEL 
Published: November 2024

Abstract
We consider continuous

${\mathrm {SL}}(2,{\mathbb R})$

valued cocycles over general dynamical systems and discuss a variety of uniformity notions. In particular, we provide a description of uniform one-parameter families of continuous

${\mathrm {SL}}(2,{\mathbb R})$

cocycles as

$G_\delta $

-sets. These results are then applied to Schrödinger operators with dynamically defined potentials. In the case where the base dynamics is given by a subshift satisfying the Boshernitzan condition, we show that for a generic continuous sampling function, the associated Schrödinger cocycles are uniform for all energies and, in the aperiodic case, the spectrum is a Cantor set of zero Lebesgue measure.
Measuring Ideological Polarization on the Circuit Courts of Appeals 1953-2022
Authors: Badas Alex 
Published: November 2024

Abstract
Attention to ideological polarization in the Circuit Courts of Appeals has surged in recent years. However, no valid cross-circuit cardinal measure of polarization has been established. The lack of a valid cross-circuit measure of polarization has limited scholar’s ability to evaluate broad trends in judicial polarization and address how ideological polarization influences judicial decision-making. To address this, I develop a new measure of ideological polarization for each of the Circuit Courts of Appeals between 1953 and 2022 using the polarization framework established by Esteban and Ray (1994). I then theorize that in order to uphold the norms of collegiality, more polarized courts are likely to take strategic actions to avoid breaking consensus. I show that polarized courts deliberate longer before releasing opinions, are less likely to give cases with a full hearing, and are less likely to publish justified and signed opinions. These results have implications for the efficiency, efficacy, and authority of the Circuit Courts of Appeals.
The Role of Judge Gender and Ideology in Hiring Female Law Clerks
Authors: Badas Alex , Sanders Bailey K. , Stauffer Katelyn E. 
Published: November 2024

Abstract
Federal law clerks play a vital role in the development and implementation of the law. Yet, women remain underrepresented in these positions. We suggest that one reason for this underrepresentation may be differences in hiring practices among judges in the federal judiciary. Specifically, we hypothesize that male judges and conservative judges may be less likely to hire female law clerks than female judges and liberal judges for two reasons. First, gendered attitudes held by judges may make some judges prone to hire women and/or others more resistant to these hires. Second, due to ideological asymmetries between the law clerk pool and judges in the federal judiciary, conservative judges and male judges may be less likely to hire women law clerks. Using data on clerks hired in the federal judiciary between 1995 and 2005, we find support for both mechanisms.1
The relationships between group-affect tone, transactive memory system, and teams’ incremental creativity
Authors: Huang Chiung-Yi , Huang Jia-Chi 
Published: November 2024

Abstract
This study explores the relationships between group-affect tone, teams’ transactive memory systems (TMSs), and teams’ incremental creativity. Data were collected from 334 team members and 70 team leaders across 70 teams. Results indicate that positive group-affect tone enhances TMS, while negative group-affect tone impedes it. TMS positively impacts team incremental creativity. Additionally, both types of group-affect tone influence incremental creativity through TMS mediation. This research advances TMS theory and group-affect tone, substantiating the affect-cognition model and deepening the understanding of TMS’s role in incremental creativity.
Driven by Clients: A Variant of Clientelism and Its Consequences for Democracy
Authors: Ordóñez Martín 
Published: November 2024

Abstract
Clientelism is traditionally viewed as a mechanism through which patrons exert control over clients. Drawing on qualitative data from three municipalities in Santiago, Chile, and building on literature that emphasizes client agency, this article explores a variant of clientelism in which clients initiate and enforce clientelistic relationships. The findings suggest that these two forms of clientelism can differently impact a crucial aspect of democracy: horizontal accountability. Client-driven clientelism compels patrons to seek resources for distribution, rendering them susceptible to influence by those who can grant them access to these resources. When patrons are tasked with accountability roles and the resource providers are subject to their oversight (as in the relationship between municipal councilors and mayors), the providers can deter these accountability functions. In contrast, patrons with independent access to resources can better preserve their autonomy.
Crossing Collaborative Borders: The Making and Becoming of ÓRALE! by David Herrera Performance Company and El Vez, the Mexican Elvis
Authors: Martinson Karen Jean , Chacón Julia E. 
Published: November 2024

Your time has come to flyYou have no borders—El Vez, “Órale,” sung to the tune of “Bridge over Troubled Waters”With brightly colored papel picado (cut paper banners), tissue flowers, and Latin American flags festooning the performance area at San Francisco's Z Space, David Herrera Performance Company's September 2023 event, ÓRALE!, promised fun and festivity. On its surface, the performance resembled a typical dance program, with an ensemble of ten dancers performing eleven separate pieces choreographed to songs from the catalog of El Vez, the Mexican Elvis, but an exciting hybrid form of movement theatre emerged through the interplay of live music, dance, and El Vez. Built around the music and performances of Robert Lopez, who has performed as El Vez for more than thirty years, ÓRALE! offered an opportunity for an intergenerational community of artists to find themselves in El Vez's work, and for Lopez to see his own vision reflected in the interpretations of the young dancers and choreographers involved. This article considers how ÓRALE! harnesses the creative possibilities of resisting the implied disciplinary borders that too often separate music, dance, and theatre performance. We begin by discussing the creative invitation that El Vez offers, to make clear how he uses his art as a form of world building, using popular culture to critique US American society, make visible the disparate cultural traditions that exist within US American cultural forms, and to envision new ways of being. We then discuss ÓRALE! following two different through lines: process and product. The collaborative process of ÓRALE! was a site of cultural, intergenerational, and geographic exchange, inviting both performers and audience into a genre-defying performance that raised critical questions around intermediality and transtemporality in the arts. As a process very much in development, the collaboration experimented with learning through doing that led to a performance event that was at times messy and at times magical. Following Elizabeth Ellsworth, ÓRALE! was an example of “knowledge in the making,” a fluid experience through which “the self is understood as a becoming, an emergence, and as continually in the making. This . . . moves us beyond a contemporary politics of difference based in semiotics and linguistics toward an experimental ‘pragmatics of becoming’ based on making and doing.” The event embodied a Muñozian process of disidentification to bring into being a utopian present, residing in this space of becoming and of knowledge in the making to reveal the complexities of Latinx subjectivity while rejecting essentialist understandings of race, ethnicity, and culture.
Integrating social innovation and public policy: lessons from early childhood education and care in Barcelona, Spain
Authors: Gallego Raquel , Maestripieri Lara 
Published: November 2024

AbstractSocial innovation has broadly been defined as citizen-led initiatives aimed at improving community welfare through collaborative relationships. However, numerous studies demonstrate that social innovation might actually create new inequalities. In this paper, we address the following questions: how might socially innovative projects influence public policy? How can we understand a policy shift leading to institutions not only giving support to social innovation projects but even promoting their own social innovation schemes? Is institution-led social innovation different from citizen-led efforts? If so, how? We provide evidence of local public policy change occurring in 0–3 education and care in Barcelona between 2015 and 2021. We explain how this happened, examining who redefined the issue and how, how the policy domain was reorganized, and how the policy subsystem was restructured. Our conclusions show how and why citizens and institutions define social innovation differently and how innovative 0–3 policy in Barcelona was adopted.
Revisiting the ‘stability–instability paradox’ in AI-enabled warfare: A modern-day Promethean tragedy under the nuclear shadow?
Authors: Johnson James 
Published: November 2024

Abstract
This article contributes to the empirical and theoretical discourse on the ‘stability–instability paradox’, the idea that while possessing nuclear weapons deters cataclysmic all-out war, it simultaneously increases the likelihood of low-level conflict between nuclear dyads. It critiques the paradox’s dominant interpretation (red-line model), which places undue confidence in the nuclear stalemate – premised on mutually assured destruction – to prevent unintentional nuclear engagement and reduce the perceived risks associated with military actions that fall below the nuclear threshold. Recent scholarship has inadequately examined the unintentional consequences of the paradox in conflicts below the nuclear threshold, particularly those relating to the potential for aggression to escalate uncontrollably. The article employs empirically grounded fictional scenarios to illustrate and critically evaluate, rather than predict, the assumptions underpinning the red-line model of the stability–instability paradox in the context of future artificial intelligence (AI)-enabled warfare. It posits that the strategic cap purportedly offered by a nuclear stalemate is illusory and that low-level military aggression between nuclear-armed states increases the risk of unintentional nuclear detonation.
A genuine need or nice to have? Understanding HTA representatives’ perspectives on the use of patient preference data
Authors: Germeni Evi , Fifer Simon , Hiligsmann Mickaël , Stein Barry , Tonkinson Mandy , Joshi Maya , Hanna Alissa , Liden Barry , Marshall Deborah A. 
Published: November 2024

Abstract

Objectives
The roles and potential value of patient preference (PP) data in health technology assessment (HTA) remain to be fully realized despite an expanding literature and various efforts to establish their utility. This article reports lessons learned through a series of collaborative workshops with HTA representatives, organized by the Health Technology Assessment International’s Patient Preferences Project Subcommittee.

Methods
Five online workshops were conducted between June 2022 and June 2023, seeking to facilitate collaborative learning and reflection on ways that PP data can be integrated into HTA. Participants included nine HTA representatives from the United States, Canada, Australia, England, and the Netherlands. Workshops were recorded, transcribed, and thematically analyzed.

Results
Despite appreciating the value of PP data, participants were ambivalent about their use in HTA. Some felt that they were already getting the information they needed from the cost-effectiveness analysis or existing patient involvement processes. Others thought that PP data would be very helpful at the initial and final stage of the decision-making process and, particularly, in the following cases: (a) when technology has important non-health benefits; (b) when the clinical and/or cost-effectiveness evidence is marginal; and (c) when treatment is indicated for a large and heterogeneous population. Issues related to the validity and reliability of PP studies were frequently raised, with preference heterogeneity at the core of these concerns.

Conclusions
Collaborating with HTA representatives in the “co-creation” of PP research can help address their concerns and facilitate mutual learning about how PP data can be used in HTA.
A Roadmap of Noninstitutional Living Options for People with Dementia: “Don’t Fence Me In”
Authors: Lévesque Maude , Oldfield Margaret 
Published: November 2024

Abstract
Canadians overwhelmingly do not want to live in long-term care institutions (LTCIs) when they age; yet many end up there for lack of home care, because family care partners burn out, or because they and their professional advisors are unaware of alternatives to institutions. Not only is institutional dementia care riven with problems, it segregates disabled people, thereby abrogating human rights. Because systemic ageism and ableism cloud seniors’ care, institutions remain the default option for Canadians with dementia. Yet, decades of deinstitutionalization enabled younger disabled Canadians to live in the community with supports. Why not seniors? We describe a plethora of noninstitutional dementia-care alternatives. We then present a roadmap for considering all relevant care options in service plans, one that incorporates supported decision making by people with dementia. We propose a paradigm shift in how Canada serves its senior citizens – not just the current generation, but those to come, including ourselves.