bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses
Authors: Winkler Zsuzsanna , Kuti Dániel , Polyák Ágnes , Juhász Balázs , Gulyás Krisztina , Lénárt Nikolett , Dénes Ádám , Ferenczi Szilamér , Kovács Krisztina J. 
Published: April 2019

AbstractGlucose is a major fuel for the central nervous system and hypoglycemia is a significant homeostatic stressor, which elicits counterregulatory reactions. Hypothalamic metabolic- and stress-related neurons initiate these actions, however recruitment of glia in control such adaptive circuit remain unknown. Groups of fed- and fasted-, vehicle-injected, and fasted + insulin-injected male mice were compared in this study. Bolus insulin administration to fasted mice resulted in hypoglycemia, which increased hypothalamo-pituitary-adrenal (HPA) axis- and sympathetic activity, increased transcription of neuropeptide Y (Npy) and agouti-related peptide (Agrp) in the hypothalamic arcuate nucleus and activated IBA1+ microglia in the hypothalamus. Activated microglia were found in close apposition to hypoglycemia-responsive NPY neurons. Inhibition of microglia by minocycline increased counterregulatory sympathetic response to hypoglycemia. Fractalkine-CX3CR1 signaling plays a role in control of microglia during hypoglycemia, because density and solidity of IBA1-ir profiles was attenuated in fasted, insulin-treated, CX3CR1 KO mice, which was parallel with exaggerated neuropeptide responses and higher blood glucose levels following insulin administration. Hypoglycemia increased Il-1b expression in the arcuate nucleus, while IL-1a/b knockout mice display improved glycemic control to insulin administration. In conclusion, activated microglia in the arcuate nucleus interferes with central counterregulatory responses to hypoglycemia. These results underscore involvement of microglia in hypothalamic regulation of glucose homeostasis.
Disentangling host-parasite-pathogen interactions in a varroa-resistant honeybee population reveals virus tolerance as an independent, naturally adapted survival mechanism
Authors: Thaduri Srinivas , Stephan Jörg G. , de Miranda Joachim R. , Locke Barbara 
Published: April 2019

AbstractThe ectoparasitic mite, Varroa destructor, is unarguably the leading cause of honeybee (Apis mellifera) mortality worldwide through its role as a vector for lethal viruses, in particular, strains of the Deformed wing virus (DWV) and Acute bee paralysis virus (ABPV) complexes. This multi-level system of host-parasite-pathogen interactions makes it difficult to investigate effects of either the mite or the virus on natural host survival. The aim of this study was to remove confounding effects of varroa to examine the role of virus susceptibility in the enhanced survival of a naturally adapted Swedish mite-resistant (MR) honeybee population, relative to mite-susceptible (MS) honeybees. Caged adult bees and laboratory reared larvae, from varroa-free colonies, were inoculated with DWV and ABPV in a series of feeding infection experiments, while control groups received virus-free food. Virus infections were monitored using RT-qPCR assays in individuals sampled over a time course. In both adults and larvae the DWV and ABPV infection dynamics were nearly identical between MR and MS groups, but MS adults suffered significantly higher mortality than MR adults. Results suggest virus tolerance, rather than reduced susceptibility or virus resistance, is an important component of the natural survival of this honeybee population.
Circular RNAs in gynecological disease: promising biomarkers and diagnostic targets
Authors: Huang Jie , Zhou Qin , Li Yunyun 
Published: April 2019

AbstractCircular RNAs (circRNAs) are a category of RNA molecules with covalently closed circles lacking both a 5′ cap and a 3′ tail. In recent years, circRNAs have attracted much attention and become a research hotspot of the RNA field following miRNAs and lncRNAs. CircRNAs exhibit tissue specificity, structural stability, and evolutionary conservation. Although the biological effects of circRNAs are still underestimated, many studies have shown that circRNAs have functions including regulation of transcription, translation into proteins and miRNA sponges. In this review, we briefly described the biogenesis and function of circRNAs and present circular transcripts in gynecological disease.
LncRNA NRON down-regulates lncRNA snaR and inhibits cancer cell proliferation in TNBC
Authors: Niu Limin , Fan Qingxia , Yan Min , Wang Liuxing 
Published: April 2019

AbstractNRON mediates the degradation of tat protein to participate in HIV-1 infection. Interestingly, our study observed the down-regulation of NRON in triple-negative breast cancer (TNBC) tissues compared with paired adjacent healthy tissues. In contrast, lncRNA snaR was up-regulated in TNBC tissues and was inversely correlated with NRON. Expression levels of snaR increased, while expression levels of NRON decreased along with the increase of clinical stages. The snaR overexpression resulted in promoted cancer cell proliferation but did not significantly affect NRON expression. NRON overexpression inhibited cancer cell proliferation and down-regulated snaR. The snaR overexpression reduced the effects of NRON overexpression. We therefore conclude that NRON may down-regulate lncRNA snaR to inhibit cancer cell proliferation in TNBC.
Identifying Developmental Language Disorder in Vietnamese Children
Authors: Pham Giang T. , Pruitt-Lord Sonja , Snow Catherine E. , Nguyen Yen Hoang Thi , Phạm Ben , Dao Thuy Bich Thi , Tran Ngoc Bich Thi , Pham Linh Thuy , Hoang Hien Thu , Dam Quynh Diem 
Published: April 2019

Purpose
Developmental language disorder (DLD), defined by low language performance despite otherwise normal development, can negatively impact children's social and academic outcomes. This study is the 1st to examine DLD in Vietnamese. To lay the foundation, we identified cases of DLD in Vietnam and explored language-specific characteristics of the disorder.

Method
Teacher ratings of 1,250 kindergarteners living in Hanoi, Vietnam, were used to recruit children with and without risk for DLD. One hundred four children completed direct measures of vocabulary and language sampling, and their parents completed in-depth surveys. We examined convergence and divergence across tasks to identify measures that could serve as reliable indicators of risk. Then, we compared performance on direct language measures across ability levels.

Results
There were positive associations between teacher and parent report and between report and direct language measures. Three groups were identified based on convergence across measures: DLD, some risk for DLD, and no risk. The DLD group performed lowest on measures of receptive and expressive vocabulary, mean length of utterance, and grammaticality. Although children with DLD exhibited a greater number of errors, the types of errors found were similar across DLD and No Risk groups.

Conclusions
Similar to rates found globally, 7% of the kindergarten population in Vietnam exhibited risk for DLD. Results highlight the importance of parent and teacher report and the value of multiple measures to identify DLD. We discuss potential clinical markers for DLD in the Vietnamese language and outline future directions.
Cell Yell!: Health Risks in Telehealth
Authors: Kisenwether Jessica S. , Anson Denis 
Published: April 2019

Purpose
The purpose of this study was to determine if the use of visual feedback can overcome the absence of side tone to control for vocal quality changes, specifically loudness, with speakerphone use.

Method
Ten men and 10 women held two 5-min conversations in pairs under audio-only and audiovisual communication conditions. Acoustical data and a number of conversational collisions (communication partners trying to speak at the same time) under each condition were compared.

Results
There were no statistically significant differences in acoustical measures of voice quality between audio-only and audiovisual conversations; however, vocal intensity was consistently 4 times more powerful than average face-to-face conversational intensity during both conditions. The number of conversational collisions was significantly less for the audiovisual condition as compared to the audio-only condition.

Conclusion
Results suggest that visual feedback did allow for modulation of conversational flow (fewer conversational collisions) but did not allow for modulation of vocal quality. Visual feedback did not overcome the absence of side tone and resulted in the same increased conversational loudness observed during the audio-only condition. As a result, remote conversational partners such as clients and telehealth practitioners are more susceptible to developing vocal health issues.
À propos de la folie et de l’amour dans Crime et Châtiment de Dostoïevski
Authors: Bazan Ariane 
Published: April 2019

Crime et Châtiment raconte l’histoire de Raskolnikov à l’été 1865 à Petersbourg, qui assassine une vieille usurière et sa sœur. Dès avant son geste Raskolnikov se met au travail quant aux questions de la culpabilité, du châtiment et de la rédemption. Le texte présente la folie humaine selon deux modalités, la névrose et la psychose, chacune avec ses deux temporalités, c’est-à-dire un premier moment de conscience d’une séparation d’avec la réalité, et un second moment de séparation effective. Raskolnikov se trouve du côté de la psychose, sur un continuel point de basculement entre les deux temps et les folies de Catherina Ivanovna et, peut-être, d’Arcady Svidrigaïlov, se trouvent du côté de la névrose, avec seul Arcady qui ne bascule pas. La seconde idée est celle de l’enjeu du crime : peut-on se trouver parmi ses frères humains de cet amour inconditionnel qui serait capable d’aimer le criminel le plus abject ? Le paradoxe est que Raskolnikov, qui ne peut supporter la transgression au point de délirer une race pure, met au défi ce monde à aimer le coupable du crime le plus vil. Nous terminerons en proposant que l’amour ne puisse être qu’inconditionnel, même s’il ne peut être illimité.
Le temps logique et les phénomènes du corps dans les psychoses ; contribution à une conception analytique de la subjectivation du corps
Authors: Tyranowski Raphaël 
Published: April 2019

Le présent travail part d’un constat clinique : la problématique du sujet contemporain nous confronte de plus en plus souvent avec des phénomènes du corps qui relèvent du registre de la psychose. En se situant dans cette dimension clinique, nous allons tenter de développer la conception structurale des psychoses pour conceptualiser une clinique différentielle des phénomènes du corps.
L’axe principal de notre élaboration est le concept de temps logique tel qu’il a été proposé par Jacques Lacan. Nous démontrons comment l’étude des temps logiques de la structure du sujet permet de situer théoriquement et approfondir cliniquement la diversité des phénomènes corporels chez le psychotique. Pour réaliser ce projet, nous conceptualisons d’abord les modalités de la subjectivation psychotique du corps qui répondent aux quatre temps logiques de la structure du sujet psychotique, pour ensuite proposer des exemples cliniques qui les illustrent.
En résumant ces résultats la dernière partie de notre travail explique comment l’inscription des phénomènes du corps dans les temps discrets du procès de la subjectivation de la jouissance aboutit à une clinique différentielle qui ouvre une perspective thérapeutique.
Urlaubsbekanntschaft mit Gifttieren an Land und im Meer
Authors: Lindert J. , Kotsias-Konopelska S. 
Published: April 2019

ZusammenfassungUnfälle mit Gifttieren bei Reisenden sind selten. Die einheimische Bevölkerung ist meist gefährdeter. Vor einer Reise wird die Information über die vorkommenden Gifttiere empfohlen. Die Verhinderung einer Gifttierverletzung durch umsichtiges Verhalten steht im Vordergrund. Kommt es zu einer Verletzung, sollte nach den allgemeinen Erstmaßnahmen ein Arzt aufgesucht werden, um zu klären, ob eine spezifische Therapie nötig ist.
KiWiZ – Gründung eines interdisziplinären Kinderwirbelsäulenzentrums am Universitätsklinikum Leipzig
Authors: Heyde C.-E. , Meixensberger J. 
Published: April 2019

ZusammenfassungDie wachsende Wirbelsäule erfordert aufgrund ihrer anatomischen und funktionellen Besonderheiten, der vielen verschiedenen Pathologien, welche häufig einen interdisziplinären Ansatz erfordern, und aufgrund verschiedener komplexer Krankheitsbilder, eine besondere und fachübergreifende Herangehensweise. Vorgestellt wird das aus diesen Gründen an der Universitätsklinik Leipzig neu gegründete interdisziplinäre Kinderwirbelsäulenzentrum. Durch eine Standardisierung der Abläufe mit einer gemeinsamen fachübergreifenden Entscheidungsfindung sowohl bezüglich der erforderlichen Diagnostik als auch der erforderlichen konservativen bzw. operativen Therapie, kann die Prozessund Behandlungsqualität für die kleinen Patienten verbessert werden. Über die Gründung und die ersten Erfahrungen in diesem Zentrum berichtet dieser Artikel.
Qualitätsmanagement in Physiotherapiepraxen
Authors: Ossendorf Andreas , Nickel Gloria Josephine 
Published: April 2019

Zusammenfassung
Hintergrund In Deutschland erbringen rund 111 000 Physiotherapeuten in ca. 38 400 zugelassenen Praxen Leistungen für Patienten mit einer Heilmittelverordnung. Physiotherapeuten sind als Leistungserbringer entscheidende Weichensteller für eine qualitativ hochwertige Behandlung und Versorgung von Patienten. Bisher sind sie zur Einführung eines Qualitätsmanagement-Systems (QM-System) grundsätzlich nicht verpflichtet, wie dies im Gegensatz dazu für Krankenhäuser, Rehakliniken und Arztpraxen im Geltungsbereich der gesetzlichen Krankenversicherung (GKV) verbindlich ist.
Ziel Mithilfe eines standardisierten Fragebogens wird ein quantitativer Überblick über den Verbreitungs- und Umsetzungsgrad sowie Wissensstand zum Qualitätsmanagement (QM) in Physiotherapiepraxen gegeben.
Methode Im Rahmen einer quantitativen Onlinebefragung wurden in Berlin, Hamburg, Köln und München rund 1000 Physiotherapiepraxen von August bis September 2017 konsekutiv anhand des amtlichen Telefonbuchs ausgewählt und angeschrieben.
Ergebnisse Die Rücklaufquote der Fragebögen betrug knapp 10 Prozent, d. h. es nahmen 93 Physiotherapiepraxen an der Befragung teil. Bisher haben 23 Praxen ein QM-System eingeführt. In Berlin ist deren Etablierung am weitesten verbreitet.
Schlussfolgerung Die Thematik QM im Gesundheitswesen wird weiter an Bedeutung gewinnen. Physiotherapiepraxen sind aufgrund zeitlicher, finanzieller und personeller Determinanten gefordert, ihren Wissensstand zu überprüfen und notwendige Veränderungsprozesse einzuleiten sowie konsequent umzusetzen.
The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase
Authors: Nitta Yoko , Ito Hideyuki , Komori Hirohumi , Ueno Hiroshi , Takeshima Daiki , Ito Mikiko , Sakaue Motoyoshi , Kikuzaki Hiroe 
Published: April 2019

ABSTRACT
Rugosin G, an ellagitannin trimer, was isolated from the water-soluble fraction of red rose petals, and its inhibitory activity against recombinant human histidine decarboxylase was investigated. Rugosin G showed potent inhibition compared to ellagitannin monomers and a dimer with macrocyclic structure (oenothein B), suggesting the potent inhibition of rugosin G was attributed to its linear oligomeric conformation.
Abbreviations: HDC, histidine decarboxylase; Me2CO, acetone; EtOAc, ethyl acetate
The Extended Evolutionary Synthesis: what is the debate about, and what might success for the extenders look like?
Authors: Lewens Tim 
Published: April 2019

Abstract
Debate over the Extended Evolutionary Synthesis (EES) ranges over three quite different domains of enquiry. Protagonists are committed to substantive positions regarding (1) empirical questions concerning (for example) the properties and prevalence of systems of epigenetic inheritance; (2) historical characterizations of the modern synthesis; and (3) conceptual/philosophical matters concerning (among other things) the nature of evolutionary processes, and the relationship between selection and adaptation. With these different aspects of the debate in view, it is possible to demonstrate the range of cross-cutting positions on offer when well-informed evolutionists consider their stance on the EES. This overview of the multiple dimensions of debate also enables clarification of two philosophical elements of the EES debate, regarding the status of niche-construction and the role of selection in explaining adaptation. Finally, it points the way to a possible resolution of the EES debate, via a pragmatic approach to evolutionary enquiry.
Hot topics and trends in cardiovascular research
Authors: Gal Diane , Thijs Bart , Glänzel Wolfgang , Sipido Karin R 
Published: April 2019

Abstract

Aims
Comprehensive data on research undertaken in cardiovascular medicine can inform the scientific community and can support policy building. We used the publication output from 2004 to 2013 and the 2014 references to these documents, to identify research topics and trends in the field of cardiovascular disease.

Methods and results
Text fragments were extracted from the titles and abstracts of 478 000 publications using natural language processing. Through machine-learning algorithms, these text fragments combined to identify specific topics across all publications. A second method, which included cross-references, assigned each publication document to a specific cluster. Experts named the topics and document clusters based on various outputs from these semi-automatic methods. We identified and labelled 175 cardiovascular topics and 20 large document clusters, with concordance between the approaches. Overarching, strongly growing topics in clinical and population sciences are evidence-based guidance for treatment, research on outcomes, prognosis, and risk factors. ‘Hot’ topics include novel treatments in valve disease and in coronary artery disease, and imaging. Basic research decreases its share over time but sees substantial growth of research on stem cells and tissue engineering, as well as in translational research. Inflammation, biomarkers, metabolic syndrome, obesity, and lipids are hot topics across population, clinical and basic research, supporting integration across the cardiovascular field.

Conclusion
Growth in clinical and population research emphasizes improving patient outcomes through novel treatments, risk stratification, and prevention. Translation and innovation redefine basic research in cardiovascular disease. Medical need, funding and publishing policies, and scientific opportunities are potential drivers for these evolutions.
Residual-type a posteriori error estimator for a quasi-static Signorini contact problem
Authors: Walloth Mirjam 
Published: April 2019

AbstractWe present a new residual-type a posteriori estimator for a quasi-static Signorini problem. The theoretical results are derived for two- and three-dimensional domains and the case of nondiscrete gap functions is addressed. We derive global upper and lower bounds with respect to an error notion, which measures the error in the displacements, the velocities and a suitable approximation of the contact forces. Further, local lower bounds for the spatial error at each discrete time point are given. The estimator splits in temporal and spatial contributions, which can be used for the adaptation of the time step as well as the mesh size. In the derivation of the estimator the local properties of the solution are exploited such that the spatial estimator has no contributions related to the nonlinearities in the interior of the actual time-dependent contact zone, but gives rise to an appropriate refinement of the free boundary zone.
Immunizations and vaccines: a decade of successes and reversals, and a call for ‘vaccine diplomacy’
Authors: Hotez Peter J 
Published: April 2019

Abstract
Over the last decade we have seen extraordinary public health gains due to expansions in global vaccination programs led by United Nations (UN) agencies, including Gavi, the Vaccine Alliance, UNICEF and the WHO. These initiatives have reduced childhood deaths from measles, tetanus and other vaccine-preventable diseases by almost one half. There is additional excitement over the potential development and introduction of new vaccines to prevent highly lethal respiratory virus infections, as well as tuberculosis, malaria, HIV/AIDS and several neglected tropical diseases. However, these successes are under threat due to political instability, conflict and an accelerating antivaccine movement. New initiatives in vaccine diplomacy will be required to combat these challenges.
Can Indirect Herbicide Exposure Modify the Response of the Colorado Potato Beetle to an Organophosphate Insecticide?
Authors: Margus Aigi , Rainio Miia , Lindström Leena 
Published: April 2019

AbstractOrganisms live in complex multivariate environments. In agroecosystems, this complexity is often human-induced as pest individuals can be exposed to many xenobiotics simultaneously. Predicting the effects of multiple stressors can be problematic, as two or more stressors can have interactive effects. Our objective was to investigate whether indirect glyphosate-based herbicide (GBH) exposure of the host plant has interactive effects in combination with an insecticide (azinphos-methyl) on an invasive pest Colorado potato beetle (Leptinotarsa decemlineata Say). We tested the effects of GBH and insecticide on the survival, insecticide target genes expression (acetylcholinesterase genes) and oxidative status biomarkers (glutathione S-transferase [GST], glucose-6-phosphate dehydrogenase [G6PDH], glutathione reductase homolog [GR], glutathione peroxidase homolog [GPx], total glutathione [totGSH], glutathione reduced-oxidized [GSH: GSSG], catalase [CAT], superoxide dismutase [SOD], lipid hydroperoxides). We found that exposure to indirect GBH has no single or interactive effects in combination with the insecticide on larval survival. However, prior exposure to GBH inhibits Ldace1 gene expression by 0.55-fold, which is the target site for the organophosphate and carbamate insecticides. This difference disappears when individuals are exposed to both GBH and insecticide, suggesting an antagonistic effect. On the other hand, oxidative status biomarker scores (PCAs of GPx, GR, and CAT) were decreased when exposed to both stressors, indicating a synergistic effect. Overall, we found that indirect GBH exposure can have both antagonistic and synergistic effects in combination with an insecticide, which should be considered when aiming for an ecologically relevant risk assessment of multiple human-induced stressors.