bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-Wide Association Analysis of Anoxia Tolerance inDrosophila melanogaster
Authors: Campbell Jacob B , Overby Paula F , Gray Alyx E , Smith Hunter C , Harrison Jon F 
Published: July 2019

AbstractAs the genetic bases to variation in anoxia tolerance are poorly understood, we used the Drosophila Genetics Reference Panel (DGRP) to conduct a genome-wide association study (GWAS) of anoxia tolerance in adult and larval Drosophila melanogaster. Survival ranged from 0–100% in adults exposed to 6 h of anoxia and from 20–98% for larvae exposed to 1 h of anoxia. Anoxia tolerance had a broad-sense heritability of 0.552 in adults and 0.433 in larvae. Larval and adult phenotypes were weakly correlated but the anoxia tolerance of adult males and females were strongly correlated. The GWA identified 180 SNPs in adults and 32 SNPs in larvae associated with anoxia tolerance. Gene ontology enrichment analysis indicated that many of the 119 polymorphic genes associated with adult anoxia-tolerance were associated with ionic transport or immune function. In contrast, the 22 polymorphic genes associated with larval anoxia-tolerance were mostly associated with regulation of transcription and DNA replication. RNAi of mapped genes generally supported the hypothesis that disruption of these genes reduces anoxia tolerance. For two ion transport genes, we tested predicted directional and sex-specific effects of SNP alleles on adult anoxia tolerance and found strong support in one case but not the other. Correlating our phenotype to prior DGRP studies suggests that genes affecting anoxia tolerance also influence stress-resistance, immune function and ionic balance. Overall, our results provide evidence for multiple new potential genetic influences on anoxia tolerance and provide additional support for important roles of ion balance and immune processes in determining variation in anoxia tolerance.
Retos y desafíos para el fortalecimiento y apoyo de las capacidades de gestión empresarial a través del trabajo comunal universitario (tcu) en las PYMES de Pococí, Limón, Costa Rica
Authors: Brenes Granados Cristian , Sandí Delgado Juan Carlos 
Published: July 2019

Este artículo se centra en la elaboración de un diagnóstico cuyo fin será determinar los retos y desafíos para el fortalecimiento y apoyo de las capacidades de gestión empresarial de las organizaciones públicas y PYMES, ubicadas en el Cantón de Pococí, Provincia de Limón, Costa Rica. La investigación llevada a cabo fue de tipo cuantitativa. Se efectuó una revisión bibliográfica y los datos primarios fueron recolectados a través de la aplicación de cuestionarios con preguntas semi- cerradas enfocadas en el tema objeto de estudio e información secundaria a través de la recopilación de documentos existentes, navegación en Internet y otras fuentes documentales relacionadas. Se concluyó que las PYMES ubicadas en el Cantón de Pococí, requieren apoyo en las áreas tales como manejo de personal, desarrollo de planes de mercadeo, desarrollo de planes estratégicos, análisis de información financiera, uso y aplicación de tecnologías, todas áreas importantes para el desarrollo y el correcto funcionamiento de las organizaciones e instituciones.
Role of Resection Following Focal Progression with Standard Doses of Imatinib in Patients with Advanced Gastrointestinal Stromal Tumors: Results of Propensity Score Analyses
Authors: Cho Hyungwoo , Ryu Min-Hee , Lee Yongjune , Park Young Soo , Kim Ki-Hun , Kim Jwa Hoon , Park Yangsoon , Lee Sun Mi , Kim Chan Wook , Kim Beom Soo , Yoo Moon-Won , Kang Yoon-Koo 
Published: July 2019

Abstract

Background
There are limited data on the clinical benefits of adding surgical resection in patients with focally progressive gastrointestinal stromal tumor (GIST). This study aims to compare the clinical outcomes of resection plus imatinib dose escalation or maintenance (S group) with imatinib dose escalation alone (NS group) in patients with advanced GIST following focal progression (FP) with standard doses of imatinib.

Materials and Methods
A total of 90 patients with advanced GISTs who experienced FP with standard doses of imatinib were included in this retrospective analysis. The primary endpoints were time to imatinib treatment failure (TTF) and overall survival (OS).

Results
Compared with the NS group (n = 52), patients in the S group (n = 38) had a higher proportion of primary tumor site involvement and lower tumor burden at FP. With a median follow-up duration of 31.0 months, patients in the S group had significantly better TTF and OS than patients in the NS group (median TTF: 24.2 vs. 6.5 months, p &lt; .01; median OS: 53.2 vs. 35.1 months, p = .009). Multivariate analysis showed that S group independently demonstrated better TTF (hazard ratio [HR], 0.29; p &lt; .01) and OS (HR, 0.47; p = .01). Even after applying inverse probability of treatment-weighting adjustments, S group demonstrated significantly better TTF (HR, 0.36; p &lt; .01) and OS (HR, 0.58; p = .049).

Conclusion
Our results suggested that resection following FP with standard doses of imatinib in patients with advanced GIST provides additional benefits over imatinib dose escalation alone.

Implications for Practice
This is the first study to compare the clinical outcomes of resection plus imatinib dose escalation or maintenance (S group) with imatinib dose escalation alone (NS group) in patients with advanced gastrointestinal stromal tumor (GIST) following focal progression (FP) with standard doses of imatinib. These findings suggest that resection can be safely performed following FP, and the addition of surgical resection provides further clinical benefit over imatinib dose escalation alone. Based on these results, the authors recommend resection following FP in patients with advanced GIST provided that an experienced multidisciplinary team is involved in the patient's treatment.
Individualized Prediction of Survival Benefit from Postmastectomy Radiotherapy for Patients with Breast Cancer with One to Three Positive Axillary Lymph Nodes
Authors: Zhang Ning , Zhang Jiashu , Zhang Hanwen , Liu Ying , Zhao Wenjing , Wang Lijuan , Chen Bing , Moran Meena S. , Haffty Bruce G. , Yang Qifeng 
Published: July 2019

Abstract

Purpose
There still exist some arguments regarding the use of postmastectomy radiotherapy (PMRT) for patients with breast cancer carrying one to three positive axillary lymph nodes considering the heterogeneity of this cohort. Here, we developed a prognostic nomogram to estimate the probability of long-term outcome in patients receiving or not receiving PMRT in order to assist in making individually locoregional treatment decisions for this particular cohort.

Methods
Altogether, 20,336 women, aged 18 to 80 years, diagnosed with breast cancer, and carrying one to three positive nodes were identified in the Surveillance, Epidemiology, and End Results (SEER) database. We applied multivariant Cox hazard model to determine the impact of covariates on disease-specific survival (DSS) and overall survival (OS). Then, the nomogram was built accordingly. Internal and external validations were performed to examine the accuracy of nomograms.

Results
Age of diagnosis, tumor grade, size, estrogen and progesterone receptor status, and number of positive nodes were independent factors of DSS and OS in the multivariate analysis. Incorporating these factors into the constructed nomogram showed high accuracy when predicting 5- and 10-year survival, with internally and externally bootstrap-corrected concordance indexes in the range of 0.6 to 0.8.

Conclusion
Besides the number of involved nodes, extra variables existed as predictors of survival outcomes in this cohort; therefore, the recommendation of PMRT or no PMRT requires comprehensive consideration. This clinically validated nomogram provided a useful tool that could aid decision making by estimating DSS and OS benefits from PMRT, useful in predicting 5- and 10-year DSS and OS for patients with one to three positive nodes after mastectomy.

Implications for Practice
This study evaluated population-based data to identify prognostic factors associated with patients with breast cancer with one to three lymph nodes and help clinicians to weigh the benefit of postmastectomy radiotherapy (PMRT). Surveillance, Epidemiology, and End Results (SEER) data were used to develop a prognostic nomogram to predict the likelihood of long-term survival with and without PMRT in order to optimize the individual locoregional control strategy for this particular cohort. This clinically validated nomogram provides a useful tool to predict 5- and 10-year disease-specific survival and overall survival for patients with one to three positive nodes and can aid tailored clinical decision making by estimating predicted benefit from PMRT.
Clustering of wind resource data for the South African renewable energy development zones
Authors: Janse van Vuuren Chantelle Y. , Vermeulen Hendrik J. 
Published: July 2019

This study investigates the use of clustering methodologies as a means of reducing spatio-temporal wind speed data into statistically representative classes of temporal profiles for further processing and interpretation. The clustering methodologies are applied to the high-resolution spatio-temporal, meso-scale renewable energy resource dataset produced for Southern Africa by the Council of Scientific and Industrial Research. This large dataset incorporates thousands of coordinates and represents a challenge from a computational perspective. This dataset can be reduced by applying clustering techniques to classify the temporal wind speed profiles into categories with similar statistical properties. Various clustering algorithms are considered, with the view to compare the performances of these algorithms for large wind resource datasets, namely k-means, partitioning around medoids, the clustering large applications algorithm, agglomerative clustering, the divisive analysis algorithm and fuzzy c-means clustering. Two distance measures are considered, namely the Euclidean distance and Pearson correlation distance. The validation metrics evaluated in the investigation includes the silhouette coefficient, the Calinski-Harabasz index and the Dunn index. Case study results are presented for the Komsberg Renewable Energy Development Zone, located in Western Cape, South Africa. This zone is selected based on the high mean wind speed and large standard deviation exhibited by the temporal wind speed profiles associated with the zone. The effects of seasonal variation in the temporal wind speed profiles are considered by partitioning the input dataset in accordance with the low and high demand seasons defined by the Megaflex Time of Use tariff. The clustered wind resource maps produced by the proposed methodology represent a valuable input dataset for further studies such as siting and the optimal geographical allocation of wind generation capacity to reduce the variability and ramping effects that are inherent to wind energy.
Ex libris tradicionales, oralidad y ladrones de libros
Authors: Sagarzazu Yeregui María Teresa 
Published: July 2019

El proceso de elaboración de los registros bibliográficos de los documentos de música impresa está lleno de sorpresas. En esta nota se describe el hallazgo de un curioso ex libris contenido en un método de violín del siglo XIX. Se trata de un tipo de ex libris tradicional en España e Hispanoamérica que sigue la fórmula clásica popular con el íncipit «si este libro se perdiera, como suele suceder...». Estos sencillos ex libris, aunque son fundamentalmente textos de transmisión escrita, muestran características estilísticas y modos de evolución propios de la transmisión oral.
Literatura oral y política actual: el presidente Trump en la literatura de cordel brasileña
Authors: Musser Ricarda 
Published: July 2019

Desde sus orígenes, la Literatura de Cordel brasileña sirve, además de como canal de noticias, como medio para comentar los acontecimientos políticos de actualidad en sus formatos específicos. La política brasileña siempre ha ocupado aquí un lugar privilegiado. A nivel internacional, cabe destacar los textos sobre Estados Unidos.
Desde que Donald Trump ostenta el título de presidente, algunos escritos han criticado con dureza su forma de hacer política, especialmente en lo que respecta a la inmigración, a la construcción del muro en la frontera con México y a su retórica.
PRE-SERVICE STUDENT TEACHERS’ PERCEPTION OF USING GOOGLE CLASSROOM IN A BLENDED COURSE
Authors: Hidayat Muhammad Luthfi , Prasetiyo Wibowo Heru , Wantoro Jan 
Published: July 2019

Purpose of the study: The strategic and learning media course in the Informatics Engineering Education department for pre-service student teachers apply a blended learning method. The purpose of this method is to integrate between face-to-face meetings in the classroom and distance learning by using internet-based Learning Management System (LMS) media. This study aims to determine the perceptions of the informatics’ pre-service student teacher, which utilize the Google Classroom LMS.
Methodology: The research method used online questionnaires and divergent questionnaires were analyzed with the Technology Acceptance Model (TAM) approach and descriptive statistics. The factor analysis included the ease of access, perception of usefulness, communication and interaction, a perception of lecture delivery, student comfortability, and the effectiveness of the Google Classroom LMS.
Main Findings: The results showed that most students felt the ease and improvement of the quality of the blended lectures using Google Classroom, although several notes needed further improvement and evaluation.
Practical Implications: The findings suggest that the stakeholders of teacher training and education faculty could measure the level of perceivers and readiness of their pre-service student teachers on using Google Classroom in a blended-setting course. Further, the pre-service student teachers have experience in using this LMS so that they could apply this learning model for their students.
Novelty/Originality of this study: This article found that students feel the satisfaction of using Google Classroom as an active and independent learning tool. This study also demonstrated consistency based on observations, surveys, and analysis of college students’ perceptions that the design of blended learning by using Google Classroom is still beneficial to the success of reaching the course outcomes.
Securitization and Desecuritization of Migration in Indonesia
Authors: Zayzda Nurul Azizah , Ash-Shafikh Maiza Hazrina , Kusuma Ayusia Sabhita 
Published: July 2019

This paper seeks to explain through an analysis using securitization theory, the dynamics of securitization and desecuritization of migration in Indonesia with a particular emphasize on the forced migration issues in the Southeast Asian region. This paper provides an analysis on the speech act represented in the legal documents or policy papers and the non-discursive practices demonstrated by the authorities in the security-related migration regulation and refugees protection. Both the occurrence of securitization and desecuritization is elaborated. The securitization is understood to take place when policy or legal documents as well current practices construct assumptions that migrants, including irregular or forced migrants pose certain threats to society. The desecuritization, meanwhile, is found in legal documents and practices that weaken the security claims regarding the migrants. It is argued here that desecuritization takes place in the midst of securitization and shifts the language of security of forced migration in regional level. The extent to which the perception of security threats imposed by the migratory process has been shifted can be reviewed in the policy changes by other individual states in the region and the international institutions working within regarding to refugees protection.
Eko-Arsitektur Dalam Agrowisata Buah-buahan di Kabupaten Demak
Authors: Khair Miftahul , Purnomo Agus Heru , Sumaryoto Sumaryoto 
Published: July 2019

<p class="Normal1"><span class="notranslate"><em><span>Tourism becomes a sector that gets more attention every year by the government, but now the form of tourism and the essence gained is less relevant.</span></em></span><em><span> <span class="notranslate">Demak Regency has similar problems, lack of varied forms of tourism, the absence of recreational and educational elements to be one cause of the number of tourists who come to be unstable and declining each year.</span> <span class="notranslate">[Demak In Figures 2015].</span> T<span class="notranslate">he form of tourism that is less environmentally friendly is the next impact.</span> <span class="notranslate">The impact on nature that is less guarded sustainability and only concerned with profit alone.</span></span></em></p><p class="Normal1"><span class="notranslate"><em><span>Alternative tourism is one of the forms completion taken.</span></em></span><em><span> <span class="notranslate">Alternative tourism has many advantages that provide a positive impact for the community directly and the environment and also provide educational and recreational value for tourists.</span> <span class="notranslate">Alternative tourism also has a selling point for the potential that exists, one of them potential fruits in the District Demak.</span> E<span class="notranslate">specially guava and star fruit, both the fruit is very abundant and many processed products from both fruit.</span></span></em></p><p class="Normal1"><span class="notranslate"><em><span>Agrotourism is an idea chosen as an alternative form of tourism which will support the concept of agri-business center from the existing local government.</span></em></span><em><span> <span class="notranslate">Agrotourism also as a means of introducing the potential of fruit and agribusiness center to the visitor with the hope that the planned place will live and the standard of living of the local community will increase.</span> <span class="notranslate">To support agrotourism that presents the concept of sustainable tourism, the Eco-architecture is raised to support the objectives of Agrotourism.</span> <span class="notranslate">In eco-architecture there are some basic thoughts that can be a solution of natural damage that occurs due to the form of mass tourism.</span> <span class="notranslate">Eco-Architecture is environmentally sound development, which utilizes the potential of nature as much as possible but still prioritizes conservation, environmental education and welfare of the surrounding community</span></span></em></p>
Penerapan Konsep Arsitektur Ekologis Pada Redesain Tempat Pelelangan Ikan Di Kota Tegal
Authors: Mulyono Aris , Yuliani Sri , Samsudi Samsudi 
Published: July 2019

<em>Indonesia as an archipelago country is very potential to develop the fishery economy. Tegal Fish Trading Market is one of facility to support fishery economic activities in Indonesia which has various problems. Redesign of Tegal Fish Trading Market with Eco-Architecture as a design strategy, expecting to solve and overcome the existing problems of the building and the area. With building evaluation, we know the problems that exist in the establishment of the Building. Then ecological principles selected to solve the problems that exist. Based on the results of identification, the ecological aspects that will be implemented is nature conservation, especially the beach and coastal, sustainable utility planning that focused on waste treatment and sanitation system, structural planning, facade, building appearance and ecological material so this building could survive in long term (sustainable). By redesign, this Fish Trading Market can be better planne, and then it will have more attractive view of buildings, planned waste treatment systems and planned sanitation systems, and also can recover the nature.</em>
URBAN TOURISM DEVELOPMENT THROUGH LOW IMPACT DEVELOPMENT (LID) TOWARDS GREEN-TOURISM
Authors: Setyaningsih Wiwik , Yuliani Sri , Iswati Tri Yuni , Nuryanti Wiendu , Prayitno Budi , Sarwadi Ahmad 
Published: July 2019

<p><em>World Tourism Organization(</em><em>WTO), </em><em>is one of theglobalissueson the international scene</em><em>, </em><em>becauseof theimpactof tourism activitieson the developmentand improvement ofthe economic, social</em><em>, </em><em>culturaland environmental qualityto the green</em><em>-tourism. </em><em>It is based with theSurakarta- city astourismandculturalcity towards the eco-city culture.</em><em> </em><em>The aim of the research, will focus on urban tourism andbuildformulationdevelopment through low impact development, in the realization ofgreen-tourism. It is based on explorative descriptive method combined with the mapping spatial of potential physical character (layout, building, and environment), included cultural, social and economic effects of tourism. The location of the research is Kauman urban settlement having a valuable unique and local potential and also its activities which are still exist right now.The result of the research, shows that the existence layout and environment of Kauman urban settlement has not been handled optimally. Moreover, it tends to lose its characteristics because it isn’t protected. Therefore, structuringa tourist areathat emphasizes theuse ofnaturalandculturalresourceswisely byprioritizingcontinued existenceandlocal knowledgetominimize thenegativeimpacts oftourismon the environment. The concept isconceivedforallparties concernedagreedthattheapplication does notgive rise tocontradictionsbetweenthe variousinterests, useful asa guideto applysustainabledevelopment of urban tourism ispaying attention tothe environmentandlocalcommunities.</em><em> </em><em>The conclusion, that purposed to fulfill the formulated of urban tourism developmentpoliciesthat are environmentally friendlyandsustainable.</em><em></em></p><p> </p><p><strong><em>Keyword</em></strong><em> :</em><strong><em>urban tourism</em></strong><strong><em>, </em></strong><strong><em>low impact development and green-</em></strong><strong><em> tourism</em></strong></p>
Older multimorbid patients’ experiences on integration of services: A systematic review
Authors: Boye Lilian Keene Guldhammer , Mogensen Christian Backer , Mechlenborg Tine , Waldorff Frans Boch , Andersen Pernille Tanggaard 
Published: July 2019

Abstract
Background

Half of the older persons in high-income counties are affected with multimorbidity and the prevalence increases with older age. To cope with both the complexity of multimorbidity and the ageing population health care systems needs to adapt to the aging population and improve the coordination of long-term services. The objectives of this review were to synthesis how older people with multimorbidity experiences integrations of health care services and to identified barriers towards continuity of care when multimorbid.

Design

A systematic literature search was conducted in February 2018 by in Scopus, Embase, Cinahl, and Medline using the PRISMA guidelines. Inclusion criteria: studies exploring patients’ point of view, ≥65 and multi-morbid. Quality assessment was conducted using COREQ. Thematic synthesis was done.

Results

2030 studies were identified, with 75 studies eligible for full text, resulting in 9 included articles, of generally accepted quality.

Integration of health care services was successful when the patients felt listened to on all the aspects of being individuals with multimorbidity and when they obtained help from a care coordinator to prioritize their appointments. However, they felt frustrated when they did not have easy access to their health providers, when they were not listened to, and when they felt they were discharged too early. These frustrations were also identified as barriers to continuity of care.

Conclusion

Health care systems needs to adapt to people with multimorbidity and find solutions on ways to create flexible systems that are able to help older patients with multimorbidity, meet their individual needs and their desire to be involved in decisions regarding their care. A Care coordinator may be a solution.