bluuebunny/crossref_metadata_2025_split huggingface dataset:
iTRAQ-based proteomics reveals SOD2 as a potential salivary biomarker in liver cancer
Authors: Ding Feng , Sun Kehuan , Sun Ningning , Jiang Qianqian , Cao Meiqun , Wu Zhengzhi 
Published: May 2019

Background: Salivary proteomic analysis has been extensively used in a wide range of cancer, but not in hepatocellular carcinoma. The aim of this study was to identify potential salivary biomarkers for hepatocellular carcinoma clinical screening. Methods: In this study, we performed isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomics analysis to detect differentially expressed proteins between saliva samples from 15 hepatocellular carcinoma patients and 15 healthy controls. Enzyme-linked immunosorbent assay (ELISA) verification was undertaken in saliva samples from 14 hepatocellular carcinoma patients and 14 healthy controls. Results: Overall, 133 proteins with significant differential expression level (ratio > 1.5 or < 0.67) were detected. Using bioinformatic analysis, two candidate proteins were selected and subsequently verified by ELISA. The increased expression of superoxide dismutase 2, mitochondrial (SOD2) in hepatocellular carcinoma patients was confirmed by ELISA, with an area under the curve value of 0.9082. Conclusions: iTRAQ-based quantitative proteomics revealed that SOD2 might serve as a potential salivary biomarker for hepatocellular carcinoma detection. Our results indicated that a noninvasive and inexpensive salivary test might be established for hepatocellular carcinoma detection.
Pregnancy outcome in women with an uncorrected single ventricle: A single-centre experience from South India
Authors: Keepanasseril Anish , Raj Ashwini , Pillai Ajith Ananthakrishna , Baghel Jyoti , Plakkal Nishad , Satheesh Santhosh 
Published: May 2019

Background Women with an uncorrected single ventricle heart are at increased risk of adverse maternal and perinatal outcomes. Methods We report our experience of managing pregnant women with uncorrected single ventricles, during the time period 2011 to 2017, in a low-resource setting and compare pregnancy outcome with healthy concurrent controls. Outcomes assessed include the mode of delivery, maternal complications, neonatal death and birth weight. Results There were six pregnant women with uncorrected single ventricles who had a total of 14 pregnancies. There was one maternal death in a woman with atrioventricular-septal defect and Eisenmenger syndrome. Caesarean section rates and preterm delivery were similar, whereas perinatal loss and low-birth weight rates were higher among women with a single ventricle compared to healthy controls. Conclusion Unplanned pregnancies without prenatal counselling/care pose a challenge to physicians especially in low to middle income countries and with the high risk of morbidity/mortality, pregnancy should be discouraged.
What kills us and what moves us: A comparative discourse analysis of heart disease and breast cancer
Authors: O’Hanlon Claire E 
Published: May 2019

Introduction Heart disease kills nearly 300,000 US women annually, while approximately 40,000 US women die of breast cancer. Breast cancer online patient communities are well known for their high engagement and emotional support. This exploratory study compared social media discourse on breast cancer with discourse related to heart disease. Methods Computer-assisted text analysis of two corpora composed of Twitter posts using #BreastCancer and #HeartDisease hashtags from December 2013 to December 2014. Lexical analysis (word and hashtag level) used AntConc software and lexicogrammatical analysis (style and stance) was conducted with DocuScope. Results The #BreastCancer corpus consisted of 592,046 posts, 57% of which were not original to the user (retweets). #HeartDisease had 269,769 posts (13% retweets). Social media discourse about #BreastCancer and #HeartDisease drew attention to women, new developments, appeals for help and disease risks. The #BreastCancer corpus incorporates gendered language and associations with art and activism, while posts about #HeartDisease were discussed scientifically in concert with other diseases. The #BreastCancer corpus uniquely included community-specific initialism hashtags. Stance analysis of the #BreastCancer corpus revealed more socially oriented posts, marked by language of constructive reasoning, inclusive language and abstract thought, while #HeartDisease corpus posts were more scholarly, used contingent and oppositional reasoning, language from institutional and academic registers, citations and meta-discourse. Conclusion The #HeartDisease social media community is less engaged, and content is less specific to both the disease and individual experience than #BreastCancer. Cultivating a women-focused heart disease online community might replicate some of the #BreastCancer community’s successes.
Utilization of Overnight Pulse Oximetry in Fibromyalgia Patients
Authors: Clark Stephanie D , Salonen Bradley R , Reddy BS Neha V , Mohabbat Arya B 
Published: May 2019

Objective To assess whether the Berlin Sleep Questionnaire and the Snoring, Tired, Observed, Pressure, Body mass, Age, Neck, and Gender questionnaire (STOP-BANG) might be suitable replacements for an overnight sleep pulse oximetry as screening tools for sleep disordered breathing in patients with fibromyalgia. Participants: From June 8, 2018 through July 25, 2018, adult patients with a confirmed diagnosis of fibromyalgia (via the 1990 and/or 2010 American College of Rheumatology Fibromyalgia Classification Criteria) who attended Mayo Clinic’s Fibromyalgia Treatment Program were invited to participate in the study. Methods: The design was a prospective comparative study with a retrospective chart review component. Participants completed 2 validated surveys: the Berlin Sleep Questionnaire and the STOP-BANG. Medical records were reviewed for demographic information and overnight pulse oximetry test results. Results: Results from both questionnaires indicate that there is an association between sleep apnea risk category (defined by questionnaire) and oximetry results. Fisher’s exact test for STOP-BANG and Berlin Sleep Questionnaire are statistically significant ( P < .001), indicating that participants at high risk for sleep apnea (based on the questionnaires) had a greater prevalence of abnormal oximetry results than those at low risk for sleep apnea. Participants who were classified as high risk (85.7%) or intermediate risk (61.5%) on the STOP-BANG questionnaire for sleep apnea had abnormal oximetry results. Participants who scored as high risk (85.7%) for sleep apnea on the Berlin Sleep Questionnaire had abnormal oximetry results. Conclusions: In patients with fibromyalgia, the Berlin Sleep Questionnaire and the STOP-BANG questionnaires could be beneficial in determining the probability of obstructive sleep apnea and the subsequent need for pulse oximetry testing, in higher risk patients.
Perverse Effects of Non-sterilized Interventions on Spot Foreign Exchange Rates
Authors: Saglam Ismail 
Published: May 2019

We study the effects of non-sterilized intervention on a spot foreign exchange (forex) rate using a multi-period game-theoretical model which involves an unspeciﬁed number of competitive traders, a ﬁnite number of strategic traders (forex dealers) with heterogenous initial money balances, and the central bank of the home country. Simulating the subgame-perfect Nash equilibrium of the two-stage game played by the forex dealers in each period, we show that the non-sterilized intervention of the central bank may lead to a perverse effect on the spot forex rate. We call the mechanism underlying this effect strategic trade switching channel that works when an increase in the central bank’s forex currency demand (supply) exerts such a big upward (downward) effect on the forex rate that some sufficiently big dealers, who optimally bought (sold) forex currency in the previous period when the forex rate was sufficiently low, ﬁnd in the current period selling (buying) it more proﬁtable, thus moving the forex rate in a direction undesired by the central bank. JEL Classiﬁcation: D43, F31, G20
Point-of-Encounter Assessment: Using Health Belief Model Constructs to Change Grading Behaviors
Authors: McLean Susan F , Francis Maureen , Lacy Naomi L , Alvarado Andres 
Published: May 2019

Objective: Fourth-year medical students need feedback to improve. Even during 1-month rotations, there needs to be a formal mid-clerkship feedback session. Better feedback involves multiple surgical evaluators at multiple levels. Constructs from the Health Belief Model of behavior change were used to assess faculty and resident grading behaviors to create a more usable evaluation system. A point-of-encounter (POE) system was created. The objective of this study was to review the efficacy of a POE clinical evaluation card (CEC) system which was initiated to increase evaluator’s participation in grading and formative feedback prior to mid-clerkship evaluation. Design: The study was a 1-year retrospective cohort study reviewing the CECs for level of evaluator, content, and student compliance. A Likert-type scale survey regarding the usage of the clinical cards was also completed by evaluators. Setting: Texas Tech University Health Sciences Center at El Paso, during 2 fourth-year medical student rotations, Subinternship (Sub-I), and Surgical Intensive Care Unit (SICU). Participants: 34 fourth-year medical students and 20 evaluators. Results: Students turned in a mean of 10 cards, 75% in SICU and 65% in Sub-I turned in all 10 cards. There were significantly greater advanced residents evaluating during Sub-I vs SICU: mean evals by PGY3 were 1.9 vs 0.75 ( p = .01) and mean evals by PGY5 were 1.4 vs 0.1 ( p < .0001). There were significantly more faculty completing evaluations during SICU vs Sub-I: 2.5 faculty evals/student vs 1.4 faculty evals/student ( p = .023). Evaluator ratings were high on a 5-point Likert-type scale, with most responses near the “strongly agree” rating of 4.7 to 4.8. Conclusions: Use of POE CECs met goals of having at least 7 CECs turned in by mid-clerkship and 10 at end-clerkships. Formative evaluations by mid-clerkship went from 0 to 7 evaluations. Evaluator surveys highlighted clarity and efficiency as reasons for using CECs.
Ultrasonography (US) in the assessment of pediatric non traumatic gastrointestinal emergencies
Authors: Fonio Paolo , Coppolino Francesco , Russo Anna , D’Andrea Alfredo , Giannattasio Antonella , Reginelli Alfonso , Grassi Roberto , Genovese Eugenio Annibale 
Published: May 2019

AbstractBackgroundNon traumatic gastrointestinal emergencies in the children and neonatal patient is a dilemma for the radiologist in the emergencies room and they presenting characteristics ultrasound features on the longitudinal and axial axis. The most frequent emergencies are : appendicitis, intussusceptions, hypertrophic pyloric stenosis, volvulus due to intestinal malrotation. The aim of this article is to familiarize the reader with the US features.MethodsA retrospective analysis of 200 ultrasound examinations performed in neonatal and children patients with fever, abdominal pain, leukocytosis, vomiting and diarrhea were evaluated.ResultsOf 200 exame 50 cases of intussusceptions, 100 cases of appendicitis, 20 cases associated with abscess;10 gangrenous appendicitis with absence a color Doppler , and 10 cases of perforated appendicitis at tomography computer integration and 10 cases of volvulus was found.ConclusionsUltrasonography (US) is therefore rapidly becoming an important imaging modality for the evaluation of acute abdominal pain, particularly in pediatric patients, where satisfactory examination is often not achievable for the attending clinicians. US provides excellent anatomic detail on the longitudinally and axial axis .
Gastrointestinal perforation: ultrasonographic diagnosis
Authors: Coppolino FF , Gatta G , Di Grezia G , Reginelli A , Iacobellis F , Vallone G , Giganti M , Genovese EA 
Published: May 2019

AbstractGastrointestinal tract perforations can occur for various causes such as peptic ulcer, inflammatory disease, blunt or penetrating trauma, iatrogenic factors, foreign body or a neoplasm that require an early recognition and, often, a surgical treatment.Ultrasonography could be useful as an initial diagnostic test to determine, in various cases the presence and, sometimes, the cause of the pneumoperitoneum.The main sonographic sign of perforation is free intraperitoneal air, resulting in an increased echogenicity of a peritoneal stripe associated with multiple reflection artifacts and characteristic comet-tail appearance.It is best detected using linear probes in the right upper quadrant between the anterior abdominal wall, in the prehepatic space.Direct sign of perforation may be detectable, particularly if they are associated with other sonographic abnormalities, called indirect signs, like thickened bowel loop and air bubbles in ascitic fluid or in a localized fluid collection, bowel or gallbladder thickened wall associated with decreased bowel motility or ileus.Neverthless, this exam has its own pitfalls. It is strongly operator-dependant; some machines have low-quality images that may not able to detect intraperitoneal free air; furthermore, some patients may be less cooperative to allow for scanning of different regions; sonography is also difficult in obese patients and with those having subcutaneous emphysema. Although CT has more accuracy in the detection of the site of perforation, ultrasound may be particularly useful also in patient groups where radiation burden should be limited notably children and pregnant women.
Mobile marketing recommendation method based on user location feedback
Authors: Yin Chunyong , Ding Shilei , Wang Jin 
Published: May 2019

Abstract
Location-based mobile marketing recommendation has become one of the hot spots in e-commerce. The current mobile marketing recommendation system only treats location information as a recommended attribute, which weakens the role of users and shopping location information in the recommendation. This paper focuses on location feedback data of user and proposes a location-based mobile marketing recommendation model by convolutional neural network (LBCNN). First, the users’ location-based behaviors are divided into different time windows. For each window, the extractor achieves users’ timing preference characteristics from different dimensions. Next, we use the convolutional model in the convolutional neural network model to train a classifier. The experimental results show that the model proposed in this paper is better than the traditional recommendation models in the terms of accuracy rate and recall rate, both of which increase nearly 10%.
A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations, and Future Research
Authors: Liu Peter Y 
Published: May 2019

AbstractContextSleep that is insufficient, misaligned, or disrupted causes hypersomnolence and neuropsychological deficits, adversely affects cardiometabolic health, and is increasingly recognized to impair other biological processes that lead to conditions important to men, such as hypogonadism, erectile dysfunction, and infertility.Evidence AcquisitionLiterature review from 1970 to December 2018.Evidence SynthesisHigh-quality and complementary epidemiological and interventional studies establish that abnormal sleep is associated with increased mortality, hypertension, and other cardiometabolic disorders (insufficient, disrupted, and misaligned sleep), as well as reduced fecundity and total sperm count (insufficient sleep), erectile dysfunction (disrupted sleep), and low testosterone (both). Circadian misalignment shifts the peak of testosterone’s diurnal rhythm to occur soon after waking up, irrespective of the biological clock time, but it does not change the mean concentration. Preliminary studies show that extending sleep in individuals who are chronically sleep deprived may become a strategy to reduce insulin resistance and hypertension. Continuous positive airway pressure therapy can improve erectile function, and possibly systemic testosterone exposure, but only when used adherently by men with obstructive sleep apnea. Both high-dose and replacement-dose testosterone therapies modestly worsen sleep-disordered breathing, but they also improve cardiometabolic function and sexual desire. Persistence of either the adverse or beneficial outcomes over the longer term requires further investigation.ConclusionsSleep is increasingly recognized to be essential for healthy living. Establishing the effect of abnormal sleep, and of improving sleep, on andrological issues of prime interest to men will promote prioritization of sleep, and may thereby improve overall long-term health outcomes.
Elegy’s Generation: Muriel Rukeyser, M. L. Rosenthal, and Poetry after the Left
Authors: Moe Lukas 
Published: May 2019

AbstractFrom the late 1930s through midcentury, poets in the United States reckoned with the decline of the political Left through a practice of elegy. The debates of interwar modernism shifted toward those of a postwar culture in which Depression-era aesthetics and politics came under the pressure of anticommunism. The 1940s work of Muriel Rukeyser, turning away from an earlier documentary poetics, exemplifies her generation’s concern with the continuity between the Popular Front and World War II rather than a retreat from New Deal reform to patriotic consensus. During this understudied period in her career spanning U.S. 1 (1938) and Elegies (1949), Rukeyser enthusiastically joined the efforts of radical poets to recover the legacy of the Spanish Civil War while modifying elegy and adapting popular genres such as the soldier’s letter to the struggles of the present. In their counterintuitive figures of address, meter, and rhyme, Rukeyser’s wartime poems offer a revisionary perspective on modern elegy and, in the context of their reception by the critic M. L. Rosenthal, an alternative to the milieus and politics of late modernism in American postwar literary culture.
Political Melodrama Meets Domestic Fiction: The Politics of Genre inNorth and South
Authors: Kucich John 
Published: May 2019

AbstractGeneric innovation has the potential to create strong new frameworks for political discourse. Elizabeth Gaskell's North and South hybridizes two nineteenth-century narrative genres—political melodrama and domestic fiction—to invite readerly involvement in the creation of new narratives of political reform. The novel “relocates” the conventions of these two genres, transplanting the formal, thematic, and rhetorical conventions of each genre to the plotlines and subject matter of the other. Such relocation undermines normative expectations about both genres and opens possibilities for new kinds of stories about social conflict. North and South exploits generic dissonance to encourage creative political engagement, stressing the urgency of reform but without fixed expectations about its outcome. Gaskell makes generic relocation possible by defamiliarizing both genres, exposing their intrinsic limitations while calling attention to the new conceptual work each genre's conventions might perform in unexpected narrative contexts. In its approach to generic hybridization, North and South typifies Condition of England novels, which routinely relocate existing generic conventions of many kinds—the bildungsroman, the regional novel, crime fiction, the roman à clef, the biblical allegory. Transplanting conventions from these various genres into narrative contexts where they seem not to belong, Condition of England novels exploit generic dissonance as an instrument of open-ended literary and political regeneration. Condition of England novels were the first group of literary texts to call on readers to participate at the national level in social reform, and generic dissonance played a key role in that literary and political act of inclusion.
Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse
Authors: Menon Debashish U. , Shibata Yoichiro , Mu Weipeng , Magnuson Terry 
Published: May 2019

ABSTRACT
A deficiency in BRG1, the catalytic subunit of the SWI/SNF chromatin remodeling complex, results in a meiotic arrest during spermatogenesis. Here, we explore the causative mechanisms. BRG1 is preferentially enriched at active promoters of genes essential for spermatogonial pluripotency and meiosis. In contrast, BRG1 is also associated with the repression of somatic genes. Chromatin accessibility at these target promoters is dependent upon BRG1. These results favor a model in which BRG1 coordinates spermatogenic transcription to ensure meiotic progression. In spermatocytes, BRG1 interacts with SCML2, a testis-specific PRC1 factor that is associated with the repression of somatic genes. We present evidence to suggest that BRG1 and SCML2 concordantly regulate genes during meiosis. Furthermore, BRG1 is required for the proper localization of SCML2 and its associated deubiquitylase, USP7, to the sex chromosomes during pachynema. SCML2-associated mono-ubiquitylation of histone H2A lysine 119 (H2AK119ub1) and acetylation of histone lysine 27 (H3K27ac) are elevated in Brg1cKO testes. Coincidentally, the PRC1 ubiquitin ligase RNF2 is activated while a histone H2A/H2B deubiquitylase USP3 is repressed. Thus, BRG1 impacts the male epigenome by influencing the localization and expression of epigenetic modifiers. This mechanism highlights a novel paradigm of cooperativity between SWI/SNF and PRC1.
‘It is a question of determination’: a case study of monitoring and evaluation of integrated family planning services in urban areas of Togo
Authors: Baker Helen , Rochat Roger , Hepburn Kenneth , Hennink Monique , Thiam Macoumba , Guede Cyrille , Koalaga Andre , Amegan Eloi , Fombo Koffi , Ogunbiyi Bolatito , Sibley Lynn 
Published: May 2019

Background: Integrating family planning into postabortion and postpartum services can increase contraceptive use and decrease maternal and child death; however, little information exists on the monitoring and evaluation of such programs. This article draws on research completed by the EngenderHealth’s AgirPF project in three urban areas of Togo on the extent to which monitoring and evaluation systems of health services, which operated within the AgirPF project area in Togo, captured integrated family planning services. Methods: This mixed methods case study used 25 health facility assessments with health service record review in hospitals, large community clinics, a dispensary, and private clinics and 41 key informant interviews with health faculty, individuals working at reproductive health organizations, individuals involved in reproductive health policy and politics, health care workers, and health facility directors. Results: The study found the reporting system for health care was labor intensive and involved multiple steps for health care workers. The system lacked a standardized method to record family planning services as part of other health care at the patient level, yet the Ministry of Health required integrated family planning services to be reported on district and partner organization reporting forms. Key informants suggested improving the system by using computer-based monitoring, streamlining the reporting process to include all necessary information at the patient level, and standardizing what information is needed for the Ministry of Health and partner organizations. Conclusion: Future research should focus on assessing the best methods for recording integrated health services and task shifting of reporting. Recommendations for future policy and programming include consolidating data for reproductive health indicators, ensuring type of information needed is captured at all levels, and reducing provider workload for reporting.