bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation
Authors: Gonçalves Tristan J. M. , Boutillon Florence , Lefebvre Suzie , Goffin Vincent , Iwatsubo Takeshi , Wakabayashi Tomoko , Oury Franck , Armand Anne-Sophie 
Published: April 2019

AbstractFusion of myoblasts into multinucleated myofibers is crucial for skeletal muscle development and regeneration. However, the mechanisms controlling this process remain to be determined. Here we identified the involvement of a new extracellular matrix protein in myoblast fusion. Collagen XXV is a transmembrane-type collagen highly transcribed during early myogenesis when primary myofibers form. Limb muscles of E12.5 and E14.5 Col25a1−/− embryos show a clear defect in the formation of multinucleated myofibers. In cell culture, the cleaved soluble extracellular domain of the collagen XXV is sufficient to promote the formation of highly multinucleated myofibers. Col25a1 is transiently expressed during myogenic differentiation and Col25a1 transcripts are down-regulated in multinucleated myofibers by a muscle-specific microRNA, miR-499. Altogether, these findings indicate that collagen XXV is required in vivo and in vitro for the fusion of myoblasts into myofibers and give further evidence that microRNAs participate to the regulation of this process.
Novel chemical route for CeO2/MWCNTs composite towards highly bendable solid-state supercapacitor device
Authors: Pandit Bidhan , Sankapal Babasaheb R. , Koinkar Pankaj M. 
Published: April 2019

AbstractElectrode materials having high capacitance with outstanding stability are the critical issues for the development of flexible supercapacitors (SCs), which have recently received increasing attention. To meet these demands, coating of CeO2 nanoparticles have been performed onto MWCNTs by using facile chemical bath deposition (CBD) method. The formed CeO2/MWCNTs nanocomposite exhibits excellent electrochemical specific capacitance of 1215.7 F/g with 92.3% remarkable cyclic stability at 10000 cycles. Light-weight flexible symmetric solid-state supercapacitor (FSSC) device have been engineered by sandwiching PVA-LiClO4 gel between two CeO2/MWCNTs electrodes which exhibit an excellent supercapacitive performance owing to the integration of pseudocapacitive CeO2 nanoparticles onto electrochemical double layer capacitance (EDLC) behaved MWCNTs complex web-like structure. Remarkable specific capacitance of 486.5 F/g with much higher energy density of 85.7 Wh/kg shows the inherent potential of the fabricated device. Moreover, the low internal resistance adds exceptional stability along with unperturbed behavior even under high mechanical stress which can explore its applicability towards high-performance flexible supercapacitor for advanced portable electronic devices.
Bacterial disease induced changes in fungal communities of olive tree twigs depend on host genotype
Authors: Gomes Teresa , Pereira José Alberto , Lino-Neto Teresa , Bennett Alison E. , Baptista Paula 
Published: April 2019

AbstractIn nature, pathogens live and interact with other microorganisms on plant tissues. Yet, the research area exploring interactions between bacteria-fungi and microbiota-plants, within the context of a pathobiome, is still scarce. In this study, the impact of olive knot (OK) disease caused by the bacteriaPseudomonas savastanoipv.savastanoi(Psv) on the epiphytic and endophytic fungal communities of olive tree twigs from three different cultivars, was investigated in field conditions. The ITS-DNA sequencing of cultivable fungi, showed that OK disease disturbs the resident fungal communities, which may reflect changes in the habitat caused by Psv. In particular, a reduction on epiphyte abundance and diversity, and changes on their composition were observed. Compared to epiphytes, endophytes were less sensitive to OK, but their abundance, in particular of potential pathogens, was increased in plants with OK disease. Host genotype, at cultivar level, contributed to plant fungal assembly particularly upon disease establishment. Therefore, besides fungi - Psv interactions, the combination of cultivar - Psv also appeared to be critical for the composition of fungal communities in olive knots. Specific fungal OTUs were associated to the presence and absence of disease, and their role in the promotion or suppression of OK disease should be studied in the future.
Deep learning versus human graders for classifying diabetic retinopathy severity in a nationwide screening program
Authors: Ruamviboonsuk Paisan , Krause Jonathan , Chotcomwongse Peranut , Sayres Rory , Raman Rajiv , Widner Kasumi , Campana Bilson J. L. , Phene Sonia , Hemarat Kornwipa , Tadarati Mongkol , Silpa-Archa Sukhum , Limwattanayingyong Jirawut , Rao Chetan , Kuruvilla Oscar , Jung Jesse , Tan Jeffrey , Orprayoon Surapong , Kangwanwongpaisan Chawawat , Sukumalpaiboon Ramase , Luengchaichawang Chainarong , Fuangkaew Jitumporn , Kongsap Pipat , Chualinpha Lamyong , Saree Sarawuth , Kawinpanitan Srirut , Mitvongsa Korntip , Lawanasakol Siriporn , Thepchatri Chaiyasit , Wongpichedchai Lalita , Corrado Greg S. , Peng Lily , Webster Dale R. 
Published: April 2019

AbstractDeep learning algorithms have been used to detect diabetic retinopathy (DR) with specialist-level accuracy. This study aims to validate one such algorithm on a large-scale clinical population, and compare the algorithm performance with that of human graders. A total of 25,326 gradable retinal images of patients with diabetes from the community-based, nationwide screening program of DR in Thailand were analyzed for DR severity and referable diabetic macular edema (DME). Grades adjudicated by a panel of international retinal specialists served as the reference standard. Relative to human graders, for detecting referable DR (moderate NPDR or worse), the deep learning algorithm had significantly higher sensitivity (0.97 vs. 0.74, p < 0.001), and a slightly lower specificity (0.96 vs. 0.98, p < 0.001). Higher sensitivity of the algorithm was also observed for each of the categories of severe or worse NPDR, PDR, and DME (p < 0.001 for all comparisons). The quadratic-weighted kappa for determination of DR severity levels by the algorithm and human graders was 0.85 and 0.78 respectively (p < 0.001 for the difference). Across different severity levels of DR for determining referable disease, deep learning significantly reduced the false negative rate (by 23%) at the cost of slightly higher false positive rates (2%). Deep learning algorithms may serve as a valuable tool for DR screening.
Triple threshold lasing from a photonic trap in a Te/Se-based optical microcavity
Authors: Sawicki Krzysztof , Rousset Jean-Guy , Rudniewski Rafał , Pacuski Wojciech , Ściesiek Maciej , Kazimierczuk Tomasz , Sobczak Kamil , Borysiuk Jolanta , Nawrocki Michał , Suffczyński Jan 
Published: April 2019

AbstractLasing relies on light amplification in the active medium of an optical resonator. There are three lasing regimes in the emission from a quantum well coupled to a semiconductor microcavity. Polariton lasing in the strong light–matter coupling regime arises from the stimulated scattering of exciton-polaritons. Photon lasing in the weak coupling regime relies on either of two mechanisms: the stimulated recombination of excitons, or of an electron–hole plasma. So far, only one or two out of these three regimes have been reported for a given structure, independently of the material system studied. Here, we report on all three lasing regimes and provide evidence for a three-threshold behavior in the emission from a photonic trap in a Se/Te-based planar microcavity comprising a single CdSe/(Cd,Mg)Se quantum well. Our work establishes the so far unsettled relation between lasing regimes that differ by their light-matter coupling strength and degree of electron–hole Coulomb correlation.
Identification of a prognostic 28-gene expression signature for gastric cancer with lymphatic metastasis
Authors: Zhang Chao , Jing Li-wei , Li Zhi-ting , Chang Zi-wei , Liu Hui , Zhang Qiu-meng , Zhang Qing-yu 
Published: April 2019

Abstract
Gastric cancer (GC) patients have high mortality due to late-stage diagnosis, which is closely associated with lymph node metastasis. Exploring the molecular mechanisms of lymphatic metastasis may inform the research into early diagnostics of GC. In the present study, we obtained RNA-Seq data from The Cancer Genome Altas and used Limma package to identify differentially expressed genes (DEGs) between lymphatic metastases and non-lymphatic metastases in GC tissues. Then, we used an elastic net-regularized COX proportional hazard model for gene selection from the DEGs and constructed a regression model composed of 28-gene signatures. Furthermore, we assessed the prognostic performance of the 28-gene signature by analyzing the receive operating characteristic curves. In addition, we selected the gene PELI2 amongst 28 genes and assessed the roles of this gene in GC cells. The good prognostic performance of the 28-gene signature was confirmed in the testing set, which was also validated by GSE66229 dataset. In addition, the biological experiments showed that PELI2 could promote the growth and metastasis of GC cells by regulating vascular endothelial growth factor C. Our study indicates that the identified 28-gene signature could be considered as a sensitive predictive tool for lymphatic metastasis in GC.
Topical therapeutic corneal and scleral tissue cross-linking solutions: in vitro formaldehyde release studies using cosmetic preservatives
Authors: Takaoka Anna , Cao Kerry , Oste Eric M. , Nagasaki Takayuki , Paik David C. 
Published: April 2019

Abstract
Our recent tissue cross-linking studies using formaldehyde releasers (FARs) suggest that corneal and scleral tissue strengthening may be possible without using ultraviolet irradiation or epithelial removal, two requirements for the photochemical method in widespread clinical use. Thus, the present study was carried out in order to better understand these potential therapeutic solutions by studying the effects of concentration, pH, buffer, time, and tissue reactivity on formaldehyde release of these FARs. Three FARs, sodium hydroxymethyl glycinate (SMG), DMDM, and diazolidinyl urea (DAU) were studied using a chromotropic acid colorimetric FA assay. The effects of concentration, pH, and buffer were studied as well as the addition of corneal and scleral tissues. The main determinant of release was found to be dilution factor (concentration) in which maximal release was noted at the lowest concentrations studied (submillimolar). In time dependent studies, after 60 min, FA levels decreased by 38% for SMG, 30% for DMDM, and 19% for DAU with corneal tissue added; and by 40% for SMG, 40% for DMDM, and 15% for DAU with scleral tissue added. We conclude that concentration (dilution factor) was found to be the most important parameter governing the percent of FA released.
The Role of Native Language and the Fundamental Design of the Auditory System in Detecting Rhythm Changes
Authors: Ordin Mikhail , Polyanskaya Leona , Gómez David Maximiliano , Samuel Arthur G. 
Published: April 2019

PurposeWe investigated whether rhythm discrimination is mainly driven by the native language of the listener or by the fundamental design of the human auditory system and universal cognitive mechanisms shared by all people irrespective of rhythmic patterns in their native language.MethodIn multiple experiments, we asked participants to listen to 2 continuous acoustic sequences and to determine whether their rhythms were the same or different (AX discrimination). Participants were native speakers of 4 languages with different rhythmic properties (Spanish, French, English, and German) to understand whether the predominant rhythmic patterns of a native language affect sensitivity, bias, and reaction time in detecting rhythmic changes in linguistic (Experiment 2) and in nonlinguistic (Experiments 1 and 2) acoustic sequences. We examined sensitivity and bias measures, as well as reaction times. We also computed Bayes factors in order to assess the effect of native language.ResultsAll listeners performed better (i.e., responded faster and manifested higher sensitivity and accuracy) when detecting the presence or absence of a rhythm change when the 1st stimulus in an AX test pair exhibited regular rhythm (i.e., a syllable-timed rhythmic pattern) than when the 1st stimulus exhibited irregular rhythm (i.e., stress-timed rhythmic pattern). This result pattern was observed both on linguistic and nonlinguistic stimuli and was not modulated by the native language of the participant.ConclusionWe conclude that rhythm change detection is a fundamental function of a processing system that relies on general auditory mechanisms and is not modulated by linguistic experience.
Array‐based target localisation in ATSC DTV passive radar
Authors: Huang Jamie Huimin , Landon Garry Joseph , Smith Graeme E. 
Published: April 2019

This work investigates the use of passive radar array‐based localisation, with a focus on experimental demonstration and practical array calibration aspects. Passive radar target localisation often employs multilateration, where a set of hyperbolic equations from range differences or elliptic equations from bistatic ranges are solved to determine the three‐dimensional (3D) target position. An alternative uses array‐based direction finding to provide an accurate measurement of target bearing, and intersects the bearing vector with a bistatic range ellipsoid to obtain a 3D target position. Continuous‐wave digitally modulated signals like digital television (DTV) provides stable power spectra and long integration times, and these support fine range and Doppler resolutions to isolate multiple targets without the association difficulties of multilateration. The Bartlett method can then be used on individual targets, giving bearing estimates of much higher accuracy than the array beamwidth. This was shown experimentally with an electrically small array yielding small angular errors in both azimuth and elevation. Using a DTV‐based passive radar, a target at 20 km receiver range was located with an accuracy of ∼250 m in a 3D position. Furthermore, a procedure for in‐situ array calibration using opportunistic air targets is reported.
Gewichtskontrolle
Authors: Buck Günther 
Published: April 2019

Zusammenfassung
Eine neue Studie zeigt, dass ein Smartphone-basiertes Programm Erwachsenen ebenso gut helfen kann an Gewicht zu verlieren wie eine Gruppenintervention – und dass es bei motivierten Menschen oft auch gar keine aufwendigen Maßnahmen braucht.
Modification of Primary Avalvular Varicose Anomaly after
endovenous radiofrequency ablation
Authors: Bissacco Daniele , Stegher Silvia , Calliari Fabio Massimo , Viani Marco Piercarlo 
Published: April 2019

AbstractPrimary avalvular varicose anomaly (PAVA) is a new medical concept defined as
primary varicose veins resembling neovascularized tissue on ultrasound
examination. PAVAs could be misdiagnosed as recurrence at the saphenofemoral or
saphenopopliteal junction, but no studies have yet examined their role before
and after venous invasive procedure. In this report, we describe a case of PAVA
in a 39-year-old man with symptomatic varicose veins and great saphenous vein
truncal incompetence. Six months after radiofrequency ablation of the great
saphenous vein, duplex ultrasound revealed complete occlusion of great saphenous
vein and partial thrombosis of the still incompetent PAVA.
Structural and electronic properties of T graphene nanotubes: a first-principles study
Authors: Xu Lin-Han , Hu Jia-Qi , Zhang Jian-Hua , Wu Shun-Qing , Chuang Feng-Chuan , Zhu Zi-Zhong , Ho Kai-Ming 
Published: April 2019

Abstract
An allotrope of graphene named T graphene was reported to reveal Dirac-like fermions and high Fermi velocity in its buckled phase similar to graphene. However, these Dirac fermions were questioned to be artificial, caused by band folding under the unstable buckling in T graphene. Here, we report first-principles studies on the structural and electronic properties of T graphene nanotubes which are systems rolled up from the two-dimensional planar sheet of T graphene. The ‘artificial’ Dirac fermions in T graphene are turned into reality in the T graphene nanotubes. Two sets of T graphene nanotubes with different diameters were studied. One set of T graphene nanotubes reveals a semi-metallic property and shows an increasing of the number of Dirac points with the diameters. Another set of T graphene nanotubes reveals a metallic property. Our study indicates that rolling up the allotrope of graphene can provide a new avenue for developing new semimetal materials with fascinating properties.
Aquatic environment and anthropogenic factor effects on distribution of trace elements in surface waters of European Russia and Western Siberia
Authors: Moiseenko T I , Dinu M I , Gashkina N A , Kremleva T A 
Published: April 2019

Abstract
The distribution of trace elements of anthropogenic origin, especially toxic metals, is an environmental problem. We present the first results of research into the geochemistry of lake waters and metallic pollution in European Russia (ER) and Western Siberia (WS), based on a survey of 367 lakes from the tundra to the steppe zones. The content of more than 80 elements in the lake water was studied; the influence of airborne contamination and the geochemistry of water were estimated. We found that the concentrations of alkaline and alkaline-earth elements, as well as As, V, Co, U, Nb, Sb, increase with a change in the climatic gradient. This fact is explained not only by airborne contamination, but also by the geochemistry of lakes and the climatic factor (increased evaporation concentration). Anthropogenic eutrophication leads to an increase in the content of Fe, Sr, Mo, and acidification—Zn, Cd, Ni, Cu, and especially Pb. There are industry-specific influences: the waters of the northern regions of ER are enriched by Ni, Cd, As, Sb and especially Se because of the emissions from copper-nickel smelters. The oil and gas industry (WS) leads to increased concentrations of V, Pb and Mo in water. We assess the metallic pollution status of surface water in the Eurasian region of Russia using an enrichment factor (EF). In surface waters of ER and WS, metal concentrations do not exceed the maximum permissible concentration, but we have established higher concentrations of many elements in the background, including toxic ones. Prolonged low doses of toxic elements can be a potential hazard to ecosystems and humans. The results showed that from the northern to the southern regions the EF increases for most of the analyzed elements. It can be assumed that with climate warming the concentration of metals in these bodies of water will increase and this is dangerous for the environment.
Inequity in postpartum healthcare provision at home and its association with subsequent healthcare expenditure
Authors: Lagendijk Jacqueline , Steegers Eric A P , Been Jasper V 
Published: April 2019

Abstract

Background
Provision of postpartum care can support new families in adapting to a new situation. We aimed to determine whether various determinants of socioeconomic status (SES) were associated with utilization of postpartum care. In addition, to stress the relevance of increasing postpartum care uptake among low SES-groups, an assessment of the potential (cost-)effectiveness of postpartum care is required.

Methods
National retrospective cohort study using linked routinely collected healthcare data from all registered singleton deliveries (2010–13) in the Netherlands. Small-for-gestational age and preterm babies were excluded. The associations between SES and postpartum care uptake, and between uptake and health care expenditure were studied using multivariable regression analyses.

Results
Of all 569 921 deliveries included, 1.2% did not receive postpartum care. Among women who did receive care, care duration was below the recommended minimum of 24 h in 15.3%. All indicators of low SES were independently associated with a lack in care uptake. Extremes of maternal age, single parenthood and being of non-Dutch origin were associated with reduced uptake independent of SES determinants. No uptake of postpartum care was associated with maternal healthcare expenses in the highest quartile: aOR 1.34 (95% CI 1.10–1.67). Uptake below the recommended amount was associated with higher maternal and infant healthcare expenses: aOR 1.09 (95% CI 1.03–1.18) and aOR 1.20 (95% CI 1.13–1.27), respectively.

Conclusion
Although uptake was generally high, low SES women less often received postpartum care, this being associated with higher subsequent healthcare expenses. Strategies to effectively reduce these substantial inequities in early life are urgently needed.
Peanut butter–based formulations of amoxicillin for pediatric applications
Authors: Tran Helen , Lee Danny , Petnic Sarah E , Bozzini Julianne A , Lu Sangwei 
Published: April 2019

Abstract

Background
Child mortality is a major global health challenge, especially in regions of limited resources. Accessibility to lifesaving medicine and adequate nutrition is essential to reduce child mortality and improve the health and well-being of the world’s most vulnerable children.

Methods
We have developed NutMox, a novel pediatric formulation of the β-lactam antibiotic amoxicillin in a matrix of peanut-based ready-to-use therapeutic food (RUTF) consisting of peanut butter, sugar, vegetable oil, dry milk and vitamins. NutMox is ready to use and thermostable, requires no chewing or pill swallowing and provides both an antibiotic and nutrition.

Results
Amoxicillin in NutMox formulations was stable for at least 12 months at storage temperatures of 4°C, 25°C and 37°C. Amoxicillin formulated in NutMox displayed similar pharmacokinetics in mice to that in suspension.

Conclusions
Our results demonstrated the feasibility of a peanut butter–based matrix for pediatric formulations of amoxicillin, suggesting that such a matrix can serve as a base for delivering medications in addition to its current use as an RUTF.