bluuebunny/crossref_metadata_2025_split huggingface dataset:
Newborn screening data management: proposing a framework for Iran
Authors: Ayatollahi Haleh , Karimi Sara , Ahmadi Maryam 
Published: January 2019

IntroductionDifferent countries use a variety of methods to manage the newborn screening data. In this study, we aimed to compare the experiences of the selected countries to propose a framework for managing the newborn screening data in Iran.MethodsIn this comparative study, data were collected using electronic databases and the official website of the Department of Health in America, England and Australia. Data related to the process of newborn screening in Iran were collected using an open-ended questionnaire and reviewing the published documents.ResultsIn this study, a framework for newborn screening data management was proposed which consisted of six main areas, namely; objectives, involved organisations, data elements, data collection processes, data classification systems and the methods of controlling data quality.ConclusionThe framework suggested in this study can help to re-organise the process of newborn screening with more focus on data management. These data can be used in conducting research and setting strategies for improving the quality of child health in the country.
Integration and evaluation of aircraft power plant production and operational data
Authors: Harsányiová Bianka , Lališ Andrej 
Published: January 2019

The paper focuses on identification of the limits of data collection based on data analyses in GE Aviation Czech, Ltd. to improve current system for data collection pertaining non-conforming products which are collected during the process of the product reconciliation. The paper contains a description of non-conformity product, data collection as well as their analysis and evaluation. Paper describes development of conceptual model of data integration about non-conformity products regarding aircraft power plant production and operation data, by the means of UFO upper level ontology. It shows the importance for building a system for collecting and evaluating data about non-conformity products in GE Aviation Czech, Ltd.
The Use of Speech Level in Socio Cultural Perspetive of Tapal Kuda Madurese Ethnic Society
Authors: Haryono Akhmad , Wibisono Bambang 
Published: January 2019

Madurese society at Tapal Kuda regions has a unique cultural tradition because of cultural acculturation with other ethnics. This research aims at describing the speech level use in socio cultural perspective of Madurese ethnic society in Tapal Kuda regions. The method used to reach the research aims is a qualitative method with an ethnographic approach. The data were collected through participatory and non-participatory observations, interviews, note-taking, and recording. The data collected were transcribed into the written data and then analysed with pragmatic theory. The use of BM with E-E, Ng-E, and È-B variation in the perspective of Madurese ethnic in Tapal Kuda is as the politeness implementation form and formal relationship among speech participants, whereas variation of BM E-I (ngoko: Javanese) in family is used to keep intimacy and closed relationship between parents and children in order not to be too formal.
Environmental pharmacology: source, impact and solution
Authors: Jena Monalisa , Mishra Archana , Maiti Rituparna 
Published: January 2019

Abstract
Environmental pharmacology is the knowledge, study and the methods implemented for amalgamating the presence of pharmaceutical products and their metabolites in the environment. Pharmaceutical and house care products and their metabolites gain access to the environment through various means and affect the flora and fauna and modulate the ecosystem. The effect on wildlife, biofilms and human are being studied to gain knowledge of sources and causations. Potential risks of development of acute and chronic toxicity, carcinogenicity, interference with hormone and immune systems and drug resistance are of major concern. They may alter the genome and can affect future generations leaving them vulnerable to disease. There are regulations in good manufacturing practices and disposal which take into account the environmental risks but the knowledge for stakeholders and their implementation is very restricted. Ecopharmacology and ecopharmacovigilance are propagators of green healthcare. A strategy towards human health risk assessment and ecotoxicological hazard evaluation must be developed and risk minimization measures to be sought for and applied.
Microalgae to biofuels production: a review on cultivation, application and renewable energy
Authors: Abo Bodjui Olivier , Odey Emmanuel Alepu , Bakayoko Moussa , Kalakodio Loissi 
Published: January 2019

Abstract
Algae are increasingly emerging as one of the most promising sustainable and long-term sources of biomass and oils for fuel, feed food and other co-products. What makes them so attractive are the large number and wide variety of benefits associated with how and where they grow. This review presents added values and recent developments in resource recovery from microalgae. The main focus was in the cultivation and application of microalgae on biofuel recovery. Nearly all these benefits stem from the fact that these plants have evolved over billions of years to produce and store energy in the form of oil, and they do this more efficiently than any other known natural or engineered process. The results show that the investment in a microalgae biomass project can be associated with various processes, which include: growth of microalgae, harvesting, dehydration and extraction of oils. In addition, there are always project costs, which include engineering, infrastructure, installation and integration and contract fees.
Increased Resurgent Sodium Currents in Nav1.8 Contribute to Nociceptive Sensory Neuron Hyperexcitability Associated with Peripheral Neuropathies
Authors: Xiao Yucheng , Barbosa Cindy , Pei Zifan , Xie Wenrui , Strong Judith A. , Zhang Jun-Ming , Cummins Theodore R. 
Published: January 2019

Neuropathic pain is a significant public health challenge, yet the underlying mechanisms remain poorly understood. Painful small fiber neuropathy (SFN) may be caused by gain-of-function mutations in Nav1.8, a sodium channel subtype predominantly expressed in peripheral nociceptive neurons. However, it is not clear how Nav1.8 disease mutations induce sensory neuron hyperexcitability. Here we studied two mutations in Nav1.8 associated with hypersensitive sensory neurons: G1662S reported in painful SFN; and T790A, which underlies increased pain behaviors in thePossumtransgenic mouse strain. We show that, in male DRG neurons, these mutations, which impair inactivation, significantly increase TTX-resistant resurgent sodium currents mediated by Nav1.8. The G1662S mutation doubled resurgent currents, and the T790A mutation increased them fourfold. These unusual currents are typically evoked during the repolarization phase of action potentials. We show that the T790A mutation greatly enhances DRG neuron excitability by reducing current threshold and increasing firing frequency. Interestingly, the mutation endows DRG neurons with multiple early afterdepolarizations and leads to substantial prolongation of action potential duration. In DRG neurons, siRNA knockdown of sodium channel β4 subunits fails to significantly alter T790A current density but reduces TTX-resistant resurgent currents by 56%. Furthermore, DRG neurons expressing T790A channels exhibited reduced excitability with fewer early afterdepolarizations and narrower action potentials after β4 knockdown. Together, our data demonstrate that open-channel block of TTX-resistant currents, enhanced by gain-of-function mutations in Nav1.8, can make major contributions to the hyperexcitability of nociceptive neurons, likely leading to altered sensory phenotypes including neuropathic pain in SFN.SIGNIFICANCE STATEMENTThis work demonstrates that two disease mutations in the voltage-gated sodium channel Nav1.8 that induce nociceptor hyperexcitability increase resurgent currents. Nav1.8 is crucial for pain sensations. Because resurgent currents are evoked during action potential repolarization, they can be crucial regulators of action potential activity. Our data indicate that increased Nav1.8 resurgent currents in DRG neurons greatly prolong action potential duration and enhance repetitive firing. We propose that Nav1.8 open-channel block is a major factor in Nav1.8-associated pain mechanisms and that targeting the molecular mechanism underlying these unique resurgent currents represents a novel therapeutic target for the treatment of aberrant pain sensations.
Heparan Sulfate Sulfation by Hs2st Restricts Astroglial Precursor Somal Translocation in Developing Mouse Forebrain by a Non-Cell-Autonomous Mechanism
Authors: Clegg James M. , Parkin Hannah M. , Mason John O. , Pratt Thomas 
Published: January 2019

Heparan sulfate (HS) is a cell surface and extracellular matrix carbohydrate extensively modified by differential sulfation. HS interacts physically with canonical fibroblast growth factor (FGF) proteins that signal through the extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK) pathway. At the embryonic mouse telencephalic midline, FGF/ERK signaling drives astroglial precursor somal translocation from the ventricular zone of the corticoseptal boundary (CSB) to the induseum griseum (IG), producing a focus ofSlit2-expressing astroglial guidepost cells essential for interhemispheric corpus callosum (CC) axon navigation. Here, we investigated the cell and molecular function of a specific form of HS sulfation, 2-O HS sulfation catalyzed by the enzyme Hs2st, in midline astroglial development and in regulating FGF protein levels and interaction with HS.Hs2st−/−embryos of either sex exhibit a grossly enlarged IG due to precocious astroglial translocation and conditionalHs2stmutagenesis andex vivoculture experiments show thatHs2stis not required cell autonomously by CC axons or by the IG astroglial cell lineage, but rather acts non-cell autonomously to suppress the transmission of translocation signals to astroglial precursors. Rescue of theHs2st−/−astroglial translocation phenotype by pharmacologically inhibiting FGF signaling shows that the normal role of Hs2st is to suppress FGF-mediated astroglial translocation. We demonstrate a selective action of Hs2st on FGF protein by showing thatHs2st(but notHs6st1) normally suppresses the levels of Fgf17 protein in the CSB regionin vivoand use a biochemical assay to show thatHs2st(but notHs6st1) facilitates a physical interaction between the Fgf17 protein and HS.SIGNIFICANCE STATEMENTWe report a novel non-cell-autonomous mechanism regulating cell signaling in developing brain. Using the developing mouse telencephalic midline as an exemplar, we show that the specific sulfation modification of the cell surface and extracellular carbohydrate heparan sulfate (HS) performed by Hs2st suppresses the supply of translocation signals to astroglial precursors by a non-cell-autonomous mechanism. We further show that Hs2st modification selectively facilitates a physical interaction between Fgf17 and HS and suppresses Fgf17 protein levelsin vivo, strongly suggesting that Hs2st acts selectively on Fgf17 signaling. HS interacts with many signaling proteins potentially encoding numerous selective interactions important in development and disease, so this class of mechanism may apply more broadly to other biological systems.
El audiovisual participativo y las ciudadanías de alta intensidad en Cazuca (Colombia)
Authors: Rocha César Augusto 
Published: January 2019

En este artículo presentaremos el proceso de la investigación “El audiovisual participativo como práctica comunicativa de transformación de los conflictos en el territorio y construcción de ciudadanías de alta intensidad”. En este artículo se presentará la investigación participativa llevada a cabo en Altos de Cazuca, comuna 4 del municipio de Soacha, en Cundinamarca (Colombia), zona de alta recepción de población desplazada por múltiples violencias, con tres grupos poblacionales. En éste se hará hincapié en cómo los grupos de pobladores con los que se desarrolló la investigación, identifican los conflictos, cómo los gestionan, y cómo pasan de ser ciudadanos del desorden a convertirse en ciudadanos de alta intensidad a través del audiovisual participativo.
Tobacco Retail Licensing and Youth Product Use
Authors: Astor Roee L. , Urman Robert , Barrington-Trimis Jessica L. , Berhane Kiros , Steinberg Jane , Cousineau Michael , Leventhal Adam M. , Unger Jennifer B. , Cruz Tess , Pentz Mary Ann , Samet Jonathan M. , McConnell Rob 
Published: January 2019

BACKGROUND:
Restricting youth access to tobacco is a central feature of US tobacco regulatory policy, but impact of local tobacco retail licensing (TRL) regulation on cigarette smoking rates remains uncertain. Effects of TRL on other tobacco product use and use as adolescents reach the age to legally purchase tobacco products has not been investigated.

METHODS:
Prevalences of ever and past 30-day cigarette, electronic cigarette (e-cigarette), cigar, and hookah use were assessed in a survey of a cohort of 1553 11th- and 12th-grade adolescents (mean age: 17.3 years); rates of initiation were evaluated 1.5 years later. An American Lung Association (2014) youth access grade was assigned to each of 14 political jurisdictions in which participants lived on the basis of the strength of the local TRL ordinance.

RESULTS:
At baseline, participants living in 4 jurisdictions with “A” grades (ie, with most restrictive ordinances) had lower odds of ever cigarette use (odds ratio [OR] 0.61; 95% confidence interval [CI] 0.41–0.90) and of past 30-day use (OR 0.51; 95% CI 0.29–0.89) than participants in 10 D- to F-grade jurisdictions. At follow-up at legal age of purchase, lower odds of cigarette use initiation (OR 0.67; 95% CI 0.45–0.99) occurred in jurisdictions with stronger TRL policy. Lower odds of e-cigarette initiation at follow-up (OR 0.74; 95% CI 0.55–0.99) and of initiation with past 30-day use (OR 0.45; 95% CI 0.23–0.90) were also associated with better regulation.

CONCLUSIONS:
Strong local TRL ordinance may lower rates of cigarette and e-cigarette use among youth and young adults.
Dusjing i sjukeheim. Eit historisk og notidig perspektiv
Authors: Boge Jeanne Helene 
Published: January 2019

SamandragIntervju med bebuarar og helsefagarbeidarar i ein norsk sjukeheim viser at pleietrengjande kunne vere misnøgd med dusj kvar 14. dag. Bebuarane var fødde i perioden 1915 – 1935, og misnøyen med vaskepraksisane kan ha samband med at dusjpraksisane i sjukeheimen braut med dei kroppslege vaskevanane som bebuarane hadde vakse opp med. Analyser av historiske studiar om kroppsvask og analyser av lærebøker i sjukepleie viser at på den tida då bebuarane vaks opp var det mest ingen hus i Noreg som hadde bad, og dusj var uvanleg. Full kroppsvask blei vanlegvis gjennomført kvar laurdag. Då sat barna gjerne i ein stamp, medan vaksne sin vekelege fullstendige kroppsvask blei gjennomført ved hjelp av ein klut og vatn i eit vaskefat. Full kroppsvask ved hjelp av dusj kvar 14. dag var med andre ord eit brot med vaskevanane som bebuarane hadde vakse opp med. Nøkkelord : Dusj, sjukeheim, habitus, historisk, kroppsvask Abstract Interviews with residents and auxilliary nurses in a Norwegian nursing home show that the residents could be dissatisfied with showers every 14. day. The residents were born between 1915 – 1935, and the dissatisfaction can be due to the differences between the bodily washing practices they had grown up with and the practices in the contemporary nursing home. Analysis of historic studies and analysis of textbooks in nursing show that at the time when the residents grew up, nearly no houses in Norway had a bathroom and showers were unusual. Full bodywash was usually conducted at Saturdays. The children could be washed in a tub, while the adults used a washbasin and a cloth at their weekely, full bodywashes. Shower every 14. day was not in league with the residents bodily washing habits. Keywords: Shower, nursing home, habitus, historic, nursing, body wash
Kişisel Değerler ve Dindarlık İlişkisi Üzerine Bir İnceleme
Authors: BALCI ARVAS Fatma 
Published: January 2019

Değerler günümüzde hem
sosyal bilim hem de din bilimleri alanının önemli konularından biridir. Hayata
dair bir anlam şeması sunan dinler, bireysel ve sosyal değerleri oluşturma ve
destekleme görevi görmektedir. Din ve değer ilişkisine dair yapılan teorik
açıklamalar ve deneysel çalışmalar, bu iki kavramın birbirini destekleyen
kavramlar olduğu fikrini kuvvetlendirmektedir. Kişisel değerler ve dindarlık
arasındaki ilişkiyi konu edinen bu çalışma, Bursa’da yaşayan 562 evli birey
üzerinde yapılmıştır. Çalışmada “Kişisel
Bilgi Formu”, “Kişisel Değerler Ölçeği” ve “Dinin Etkisini Hissetme Ölçeği”
kullanılmıştır. Bulgulara göre, dindarlık ve kişisel değerlerin demografik
değişkenlere göre farklılaştığı görülmüştür. Ayrıca analiz sonuçlarına göre
kişisel değerler ve dindarlık arasında pozitif yönlü anlamlı ilişkiler tespit
edilmiştir.
Psikolojik Sermayenin ve İş Tatmininin Performans Üzerindeki Etkisi: Teknoloji Sektöründe Bir Araştırma
Authors: PELENK Saadet Ela 
Published: January 2019

İş hayatında yaşanan
hızlı değişimler, çalışanların yeteneklerini geliştirmelerini gerektirmektedir. Seligman (1990) tarafından literatüre
kazandırılan psikolojik sermaye kavramı, “umut, iyimserlik, dayanıklılık ve öz
yeterlilik” faktörleri ile çalışanın yeteneklerine odaklanan, pozitif bir davranıştır.
Ancak iş hayatının zorlukları, bazen
çalışanı psikolojik ve fiziksel açıdan zor durumda bırakmaktadır. Bu noktada
amiri, çalışanın sürekli olumsuz özelliğine odaklanıp, destek vermezse
çalışanın iş tatmini ve performansı azalacaktır. Çünkü pozitif bir duygu olan
psikolojik sermaye, iş tatmini ve performansı etkileyebilir. Araştırmanın
amacı, psikolojik sermaye ve iş tatmininin
performansa etkisini incelemektir. Araştırmada anket yöntemi ile teknoloji
sektörünün 154 çalışanından veriler toplanmıştır. Araştırma sonucuna göre, psikolojik
sermaye ve iş tatmini performansı pozitif ve anlamlı şekilde etkilemektedir.
Sınıf Dışı Eğitim Faaliyetlerinin Öğrencilerin Bilim ve Teknolojiye Yönelik Tutumlarına Etkisi ve Duygu Analizi
Authors: GÖLOĞLU DEMİR Cennet , YILMAZ Hakan 
Published: January 2019

Bu araştırmada sınıf dışı
eğitim faaliyeti olarak Dört Gün, Dört Tema:Bilim adlı TÜBİTAK projesinin
öğrencilerin tutumlarına ve duygularına etkisi araştırılmıştır. Araştırmanın
çalışma grubunu, amaçlı örnekleme yöntemiyle belirlenmiş olan 40 altıncı sınıf
öğrencisi oluşturmaktadır. Araştırmada deneysel yöntem, doküman incelemesi ve
duygu analizi yöntemi kullanılmıştır. Araştırma
sonucunda öğrencilerin “Bilimi Kullanma”, “Teknolojiye Yönelik Eğilim”,
“Teknolojinin Katkısı ve Önemi” alt boyutu tutum puan ortalamaların da anlamlı
bir artış, “Teknolojinin Olumsuzluğu” alt boyutu puan ortalamasında ise anlamlı
bir düşüş görülmüştür. Öğrencilerin projeye yönelik duygularının da olumlu
yönde olduğu tespit edilmiştir. Öğrenciler
proje süresince eğlendiklerini ve mutlu olduklarını ifade etmişlerdir.
İnme Hastalarında Tam Kan Sayımı Parametreleri Fonksiyonel Seviyeyi Gösterir mi?
Authors: KOCA Tuba Tülay , ARSLAN Aydın 
Published: January 2019

Amaç: İnflamasyon, inme patogenezinde çok önemli bir role
sahiptir, son yıllarda tam kan parametre ve türevleri çeşitli
hastalıkların seyrinde kötü prognoz kriteri olarak yol gösterici bulunmaktadır. Burada çeşitli tam kan parametre ve
türevlerinin inmeli hastaların fonksiyonel seviyeleriyle ilişkisini ortaya
koymayı amaçladık.Gereç ve Yöntem:
Kliniğimize 2016-2017 yılları arasında yatarak tedavi gören inme tanılı
hastalar retrospektif olarak analiz edildi. Tüm hastaların yaş, cinsiyet,
etiyoloji, tutulan taraf, spastisite varlığı, fonksiyonel ambulasyon seviyeleri
(FAS), üst ve alt ekstremite Brunnstrom evreleri kayıt edildi. Tüm hastaların
yatış sırasındaki tam kan sayısı ve alt parametreleri, beyaz küre (WBC),
eritrosit dağılım genişliği (RDW), platelet dağılım genişliği (PDW), ortalama
platelet volüm (MPV) ile akut faz reaktanları, eritrosit sedimentasyon hızı
(ESR), C-reaktif protein (CRP) kayıt edildi. Bulgular: Çalışmamıza 32-85 yaş aralığında 55 erkek (%
63.2), 30 kadın (% 34.5) hasta dahil edildi.
Hastaların % 64’ü 1 yıldan kısa süre inme tanılı, % 86.2’si iskemik, % 50.6’sı
sağ taraf tutulumlu idi. Hastaların % 25.3’ünde
spastisite yoktu. Spastisite gözlenenler içinde en sık % 23 oranı ile Ashworth
evre 1 spastisite gözlendi. Fonsiyonel düzeyleri en sık % 20.7 oranı ile FAS
3, üst ekstremite % 32.2 oranı ile Brunnstrom
evre 3, alt ekstremitede % 28.7 oranı ile Brunstrom evre 5 seviyede idi.

Sonuç:
İnflamasyon parametreleri inmeli hastalarda
fonksiyonel seviye hakkında bilgi vermektedir. İnflamatuar reaksiyonu
tetikleyen sistemik inflamasyonu veya nöronal yolların inhibisyonu inme
hastalarında gelecekteki potansiyel tedavi hedefleridir.
Implementasi Algoritma C4.5 Dalam Menentukan Lokasi Prioritas Penyuluhan Program Keluarga berencana di kecamatan dumai timur
Authors: Sari Febrina , Saro David 
Published: January 2019

<p class="JGI-AbstractIsi"><span lang="EN-US">Indonesia merupakan salah satu negara dengan penduduk terbanyak di dunia. Ledakan penduduk ini terjadi karena laju pertumbuhan penduduk yang sangat tinggi. kondisi ini menyebabkan beban negara menjadi semakin besar. Karena berhubungan dengan tinggi rendahnya beban negara untuk memberikan penghidupan yang layak kepada setiap warga negaranya, maka pemerintah memberikan serangkaian usaha untuk menekan laju pertumbuhan penduduk agar tidak terjadi ledakan penduduk yang lebih besar. Salah satu cara yang dilakukan oleh pemerintah adalah dengan menggalakkan Program Keluarga Berencana (KB). program keluarga berencana yang dicanangkan oleh pemerintah untuk menekan angka kelahiran yang tinggi ini belum sepenuhnya terlaksana dengan baik karena lokasi penyuluhan program KB yang belum tepat sasaran. Oleh karena itu diperlukan suatu sistem yang dapat membantu Badan Kependudukan dan Keluarga Berencana Nasional (BKKBN) dalam menentukan lokasi Prioritas Penyuluhan Program Keluarga Berencana agar penyuluhan tepat sasaran. Data Mining adalah kegiatan mengekstraksi atau menambang pengetahuan dari data yang berukuran besar, algoritma C4.5 merupakan algoritma yang digunakan untuk membangun sebuah pohon keputusan (Decision Tree) dari data. Algoritma C4.5 umumnya digunakan untuk melakukan klasifikasi yang nantinya akan digunakan dalam menetapkan lokasi prioritas penyuluhan program Keluarga Berencana.</span></p>