bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Healthcare-Seeking Decisions Delay During Acute Exacerbations in Elderly Patients with Chronic Heart Failure: An Analysis Based on a Cross-Sectional Study
Authors: Wang Bei-Bei , Wang Si-Yi , Han Si-Xuan , Yang Xiao-Bin , Liu Qi-Di , Chen Shao-Yue , Wu Xiao-Xian , Shen Bin , Lin Yan-Li , Hong Yan-Yan 
Published: December 2024

Abstract

Background: Elderly patients with chronic heart failure often experience significant delays in making healthcare-seeking decisions from the onset of symptom acute exacerbations to the final decision to seek medical care. Guided by the Health Belief Model and the Theory of Planned Behavior, this study investigates the duration and factors influencing delayed healthcare-seeking decisions following symptom acute exacerbations in elderly patients with chronic heart failure.
Methods: A cross-sectional study was conducted from November 2023 to June 2024, involving 244 elderly patients with chronic heart failure hospitalized in two general hospitals in Nanjing, China. Data were collected using a questionnaire survey. The distributed questionnaire included a General Information Questionnaire for Heart Failure Patients, the Chinese version of the Heart Failure Somatic Perception Scale, the Chinese version of the Perceived Barriers to Care Seeking Scale, the Symptom Management Self-Efficacy Scale, the Chinese version of the Social Support Rating Scale, and the Simplified Coping Style Questionnaire.
Results: The results showed that the healthcare-seeking decisions time among the 244 patients ranged from 2 hours to 4410 hours, with a median time of 187.5 hours (7.8 days), Q1 of 82.0 hours, and Q3 of 504.5 hours. Regression analysis indicated that symptom management self-efficacy ( β = 0.637, P < 0.001), social support (β = -0.194, P < 0.001), the location of onset (β = -0.147, P < 0.001), heart failure somatic perception (β = -0.147, P = 0.002), the onset pattern (β = -0.121, P = 0.005), and attempts at self-management (β = 0.107, P = 0.023) were significantly associated with the delay in healthcare-seeking decisions.
Conclusion: This study demonstrates that delayed healthcare-seeking decisions are common among elderly patients with chronic heart failure in China. The factors influencing this delay include symptom management self-efficacy, social support, location of onset, heart failure somatic perception, and onset pattern. These findings not only enhance our understanding of healthcare-seeking behavior in heart failure patients but also provide a scientific basis for developing more effective interventions.
Left atrial appendage cannulation for left ventricular unloading in a patient with ventricular thrombus on extracorporeal life support
Authors: Schaefer Anne-Kristin , Wiedemann Dominik , Heinz Gottfried , Riebandt Julia , Zilberszac Robert 
Published: December 2024

Abstract

Background
Left ventricular unloading is needed in patients on extracorporeal life support (ECLS) with severely reduced left ventricular contractility to avoid stasis and pulmonary congestion, and to promote LV recovery. The presence of thrombi in the LV precludes the use of conventional active unloading methods such as transaortic microaxial pumps or apical LV vents. We describe placement of a vent cannula via the left atrial appendage (LAA) as a useful bailout option.
Case Presentation:
A 61-year-old patient presenting with normotensive cardiogenic shock (SCAI C) after subacute anterior wall myocardial infarction deteriorated with pulmonary edema and ventricular fibrilation, requiring veno-arterial extracorporeal life support under ongoing CPR (SCAI E). An Impella CP was placed for LV unloading, but was unable to generate flow and removed. A large left ventricular thrombus was detected as the cause for insufficient Impella flow. For urgent LV unloading, we placed a vent cannula via the LAA through a thoracotomy to bridge our patient to total artificial heart implantation. However, intraoperative TEE showed resolution of the LV thrombus, enabling to change the strategy to left ventricular assist device implantation. Our patient made a full recovery and is now doing well in regular outpatient follow ups.
Conclusions
ECLS provides excellent circulatory support at the price of a high complication burden and considerable LV afterload increase. ECLS complications often require individualized solutions not represented in current HF guidelines. This patient has developed a dreaded and nearly always fatal ECLS complication, which was successfully managed with vent placement via the LAA.
Evaluating the Role of Calcium Dobesilate in COVID-19-Related Pulmonary Vascular Endotheliitis and Thrombosis: A Retrospective Analysis of Real-World Data
Authors: Flota-Cervera Luis Fernando , Arellano-Bárcenas Alejandra , Salazar-G José Luis , Alexanderson-R Elvira Graciela , Martins-G Alina , Morin-Contreras Andrea , Gonzalez-G Francisco , Zingg Daniel 
Published: December 2024

Abstract

Background
SARS-CoV-2 (COVID-19) infection is known to cause acute inflammatory pulmonary microangiopathy, leading to alveolar-capillary thrombosis, severe respiratory failure, and potential mortality. This study aims to evaluate the efficacy of calcium dobesilate (CaD) in treating COVID-19-related pulmonary complications using real-world data.
Methods
This retrospective study included 60 COVID-19 patients treated with CaD in addition to standard care at three outpatient centers in Mexico City and Guadalajara. Patient data, including demographics, medical history, COVID-19 symptoms, and concomitant treatments, were collected from medical records.
Results
The median dose of CaD was 2 grams per day, starting on the third day after diagnosis and continuing for a median of 28 days. Half of the patients also required steroid therapy, with 14 receiving dexamethasone and 16 receiving prednisone. Additionally, 23.3% of patients required oxygen therapy, with volumes ranging from 3 to 10 liters per minute. Improvement in clinical symptoms was observed after a median of 18.6 ± 10.6 days (n = 50), with full recovery occurring after 25.6 ± 10.3 days (n = 42). Importantly, no deaths or long-term complications were reported among the study participants.
Conclusion
The use of CaD in treating COVID-19-associated pulmonary microangiopathy shows promising outcomes, with a notable absence of mortality or severe sequelae. However, future randomized, double-blind, placebo-controlled trials with larger sample sizes are essential to confirm these findings and establish CaD's role in COVID-19 management.
An interlaced toolpath strategy for void reduction in material extrusion additive manufacturing
Authors: Sun Xiaochen , Mazur Maciej , CHENG Chi-Tsun 
Published: December 2024

Abstract

Material Extrusion (MEX) is one of the most popular forms of Additive Manufacturing (AM) technologies due to its accessibility, versatility, and cost-effectiveness. However, the layer-by-layer and track-by-track nature of MEX technology is prone to the formation of defects, such as voids between deposited material tracks, which are detrimental to the print’s structural integrity and visual quality. Intertrack voids are the primary type of void in most MEX parts. This work proposes an interlaced toolpath material deposition strategy for Fused Filament Fabrication (FFF) technologies that can reduce the formation of inter-track voids. Unlike other proposed void-minimising strategies based on thermal post-treatments, laser, or ultrasonic-assisted deposition methods, the proposed one is a software-based approach that does not require hardware modification or part-post processing. While other state-of-the-art void-minimising strategies concentrate mainly on improving print quality and often omit their corresponding impact on other aspects, this research treats toolpath generation as a multi-objective optimisation problem, aiming to enhance the print’s mechanical performance with an insignificant degradation in the print’s dimensional accuracy.
Outcomes of Hematopoietic Stem Cell Transplantation in Children with Sickle Cell Disease: Does Donor Sickle Cell Trait Status Matter?
Authors: Bayoumy Mohamed , Raffa Enass , Al-Seraihy Amal , Abosoudah Ibraheem , Orabe Amany , Altrabolsi Hassan , Ahmed Abdulatef , Elhadidy Marwa , AlKhateeb Lamis , Jastaniah Wasil 
Published: December 2024

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) remains the gold standard curative therapy for sickle cell disease (SCD). A matched related donor (MRD) with sickle cell trait (SCT) is a viable option, with no evidence of adversely affecting transplant outcomes. We conducted a retrospective chart review of children (≤ 14 years) who underwent myeloablative HSCT from MRDs for SCD between 2013 and 2023, comparing outcomes for MRD with SCT to those with normal hemoglobin (Hgb) electrophoresis. Overall, 73 children underwent HSCT at a median age of 11.3 years. The main indication for HSCT was central nervous system insult in 43 (60%) patients. Among the donors, 48 (66%) had SCT, whereas 25 (34%) had normal Hgb electrophoresis. The mean time to neutrophil and platelet engraftment was 21.3 (10–84) and 22.61 (14–78) days, respectively. None of the patients developed graft rejection. The incidence of both acute and chronic graft-versus-host disease (GVHD) was similar across the donor groups. With a remarkable 5-year overall survival and disease-free survival rate of 97.3%, our findings demonstrate that there is no significant difference between donor groups. Our results align with international HSCT outcomes for SCD, reinforcing the efficacy of allogeneic HSCT from MRDs, regardless of SCT status.
Pharmacy Role In the proMotion of continencE (PRIME): a co-production study to develop a Pharmacy Bladder and Bowel Service
Authors: Cotterill Nikki , Uren Alan , Williams Ade , Chandler David , McLeod Hugh , Dawson Shoba , Watson Margaret 
Published: December 2024

Abstract

Background
Urinary and faecal incontinence affects millions. Community pharmacies provide local community healthcare highlighting opportunity for innovation in continence promotion. The Pharmacy Role In the proMotion of continencE (PRIME) study was conducted to investigate development of a Pharmacy Bladder and Bowel Service (PBBS) incorporating key stakeholder engagement.
Methods
A UK online survey of community pharmacy staff identified current practice, and barriers and facilitators to PBBS development. Findings from earlier PRIME sub-studies: systematic literature review and qualitative interviews were incorporated into an evidence brief alongside the survey findings. This evidence informed key stakeholder participant discussions at two workshops using co-production methodology.
Results
Twenty-nine community pharmacy participants completed the survey reporting some provision of lifestyle advice in practice with clear scope for expansion.
Sixteen participants including Community Pharmacists, Bladder and Bowel Service staff, Service users and healthcare commissioners participated in workshops. A protocolised service specification was derived detailing underpinning requirements and scope of service. Record sharing, advances in training, and reimbursement are required to enable the PBBS to be viable for community pharmacy provision. Acknowledged limitations are the pressures and relatively novel nature of pharmacy research which presents challenge in promoting participation.
Conclusions
This is the first evidence-based PBBS service specification, developed to inform future practice. An evaluation of implementation along with clinical and cost-effectiveness will be undertaken to inform optimised uptake. The PBBS provides potential for early identification, promotion of continence health, and self-help activation in community settings.
Association between CDSS score and 30-day mortality in non-APL acute leukemia patients with intracranial hemorrhage: A cohort study
Authors: Zhang Jia-Yuan , Yan Zhang-Song , Li Da-Peng , Sun Xiu-Juan , Liu Yong-Ze , Yin Yan-Ke , Hu Bo , Su Ming-Huan , Li Qiu-Ling , He Jin-Song , Li Jie-Si , Mi Ying-Chang 
Published: December 2024

Abstract

Objectives
The aim of this study was to investigate the correlation between CDSS (Chinese DIC Scoring System) score and 30-day mortality in patients with intracranial hemorrhage (ICH) with nonacute promyelocytic leukemia (APL) acute leukemia.
Methods
This cohort study enrolled patients with non-APL acute leukemia complicated by ICH. The CDSS score was assessed in this patient population. Multivariable Cox regression was used to analyze the association between CDSS score and 30-day mortality. Additionally, interaction and stratified analyses were conducted based on variables such as age, sex, white blood cell count, platelet count, and albumin levels.
Results
In a study involving 82 patients diagnosed as nonAPL acute leukemia with ICH, the overall 30-day mortality rate was 61.0%, with 50 out of the 82 patients succumbing to the condition. Among those with CDSS scores ≥ 6, the mortality rate was 87% (20 out of 23), which was higher than the 50.8% mortality rate of the CDSS scores < 6 group (30 out of 59) (p = 0.002). In multivariate regression models, a 28% increase in 30-day mortality was linked to a one-point increase in CDSS score(HR = 1.28, 95% CI 1.06–1.56). Furthermore, it was associated with a 124% increase in 30-day mortality in CDSS scores ≥ 6 compared with that in the CDSS scores < 6 (HR = 2.24, 95% CI 1.1–4.56). Interaction analysis revealed no significant interactive effect on the relationship between CDSS score and 30-day mortality.
Conclusions
The CDSS score was linked to a higher 30-day mortality rate, particularly in patients with CDSS scores ≥ 6.
Management and protection of soil resources using smart technologies to measure and predict erosion mechanism
Authors: Ikram Rana Muhammad Adnan , Wang Mo , Moayedi Hossein , Dehrashid Atefeh Ahmadi , Gharibi Shiva 
Published: December 2024

Abstract

Soil is a critical natural resource, and accurate estimation of soil erosion is vital for the optimal management and development of soil resources. Soil erosion assessment is necessary for long-term conservation plans, but the process can be expensive and time-consuming over large areas. It is imperative to examine the impact of water-induced soil erosion on cultivated lands, as it can cause significant damage. This study evaluates the effectiveness of four data-driven approaches (biogeography-based optimization, earthworm optimization algorithm, symbiotic organisms search, and whale optimization algorithm) combined with artificial neural network models in estimating soil erosion. The examined criteria include 14 geographic and environmental criteria, and the data used in a ratio of 70 to 30 for training and testing operations. And its results were measured by AUC values. The evaluation of AUC accuracy indices revealed compelling results. Specifically, in the case of SOS-MLP, the highest AUC values were observed, reaching 0.9973 for test data and 0.9296 for train data. Conversely, for WOA-MLP, the AUC values obtained were slightly lower but still notable, registering at 0.9809 for test data and 0.959 for train data. These values were also calculated for BBO-MLP (0.999 and 0.9327) and EWA-MLP (0.9304 and 0.9296) in the training and testing phases, respectively. Results showed that all four methods could successfully evaluate erosion susceptibility according to AUC values greater than 0.92, especially the BBO-MLP with the highest AUC values. Therefore, the findings of this study have shown that the combined optimization algorithms and Machine Learning used in this research have a suitable ability to optimize the artificial neural network and are very useful for identifying areas sensitive to erosion.
Using the DCJM deep-learning model to diagnosis drug-resistant lymph node tuberculosis based on ultrasound images: A Multicenter Study
Authors: Chen Peijun , Luo Jialei , Yan Xinyi , Zhang Ying , Zhang Wenzhi , Yang Gaoyi 
Published: December 2024

Abstract

Our objective was to develop a deep learning model based on grey-scale ultrasound (GUS) images for predicting whether lymph node tuberculosis (LNTB) of the neck is drug resistant. The GUS images of 297 cases of cervical LNTB confirmed to be drug-resistant or sensitive by laboratory examination in three hospitals were retrospectively collected. A target detection-image classification joint learning method (DCJM) model combining target detection and image classification was constructed from the training set, and the diagnostic efficacy of the DCJM model was evaluated by the data from the internal validation set, Test A and Test B. We used mean average precision (mAP) to assess the accuracy of target detection in the DCJM model, The mAP_0.5 and mAP_0.5:0.95 of the DCJM model for LNTB detection were 0.995 and 0.897, respectively. The area under the curve (AUC) of this model in the training set, validation set, Test A, and Test B were 0.992 (95% CI, 0.972-1.000), 0.851 (95% CI, 0.733–0.948), 0.727 (95% CI, 0.488–0.924), and 0.777 (95% CI, 0.644-0.900), respectively. The DCJM model has a strong detection function as well as a good predictive value for drug-resistant LNTB, providing valuable information for individualized treatment decisions.
Combining Immunotherapy with Anlotinib in Extensive-Stage Small Cell Lung Cancer: A Multicenter Analysis of Efficacy and Safety
Authors: Gao Guogang , Sun Meiling , Deng Fang , Li Jingyi , Yu Ge , Ji Huaijun 
Published: December 2024

Abstract

Background: Patients with extensive-stage small cell lung cancer (ES-SCLC) face considerable therapeutic challenges and limited survival outcomes. This study aimed to evaluate the efficacy and potential synergistic effects of combining immunotherapy (IT) with anlotinib in patients with ES-SCLC.
Methods: We enrolled patients with ES-SCLC who received regular treatment at three centers from January 2020 to January 2024. Survival outcomes were compared using the Kaplan-Meier method and Cox proportional hazards regression.
Results: A total of 147 eligible patients with ES-SCLC were included in the analysis. The median overall survival (mOS) for all patients was 15.5 months (95% CI, 13.9-17.1). In the chemotherapy combined with immunotherapy (CT+IT) group, the mOS was 17.8 months, compared to 12.6 months in the CT group (p = 0.055). The median progression-free survival (mPFS) was 7.1 months in the CT+IT group and 6.5 months in the CT group (p = 0.157). Additionally, when the cohort was divided into three groups (CT+IT+Anlotinib, CT+IT and CT alone), the mOS was 18.5, 16.3, and 12.6 months, respectively. A significant improvement in OS was observed in the CT+IT+Anlotinibgroup compared to the CT-alone group (p = 0.044), although there were no significant differences in PFS among the three groups (7.3 months vs. 6.9 months vs. 6.5 months). Multivariate analysis identified radiotherapy (p = 0.003) and immunotherapy (p = 0.021) as independent prognostic factors for OS, while liver metastasis (p = 0.023) and radiotherapy (p = 0.018) were independent predictive factors for PFS. Furthermore, patients treated with radiotherapy (RT) and CT showed significant improvements in OS (17.5 months vs. 12.5 months; p = 0.002) and PFS (7.3 months vs. 6.3 months; p = 0.004) compared to those who received CT alone. The rates of treatment-related adverse events were similar across the three groups (p = 0.721).
Conclusion: An increasing number oftreatment options are being explored for ES-SCLC, and CT is the cornerstone of treatment for this disease. The combination of Anlotinib with IT can significantly prolong survival in patients with ES-SCLC, while maintaining an excellent safety profile, and such treatments are worthy of further exploration.
A study of the effects of fresh and processed fish oils of Tenualosa ilisha, Mystus bleekeri, and Puntius sophore on Experimental Model on Atherosclerosis
Authors: Goswami Sanchari , Bala Asis , Gandla Kumaraswamy , Debnath Bikash , Singh Waikhom Somraj , Repudi Lalitha , Mande Srinivasarao , Manna Kuntal 
Published: December 2024

Abstract

Background
Fish and rice are very popular among the common people of Tripura. Different types of processed fish are available in Tripura, and they are very popular because of their taste and odor. They are the primary source of omega-3 polyunsaturated fatty acids. analysis of Atherosclerosis activities of processed fish samples of Tripura has not been explored scientifically. The aim of the present study is to evaluate the anti-atherosclerosis activity of laboratory-extracted fish oils of fresh and processed (salted, sun-dried, and fermented) samples of T. ilisha, M. bleekeri, and P. sophore.
Methods
For the above purpose, Swiss albino mice (20–25 g) was taken and developed atherosclerosis by feeding a high-fat experimental diet for three months at Animal House, Tripura University. At the end of the three months, in vivo atherosclerosis activity was measured by estimation of biochemical composition, plasma component, liver component, and determination of collagen, calcium, and protein.
Result
From the above study, it was observed that fresh T. ilisha oil was able to reduce the amount of cholesterol, cholesterol esters, and unesterified cholesterol. In fresh T. Ilisha unesterified cholesterol content and total cholesterol content was significantly decreased than the standard diet of olive oil (**p < 0.05, ##p < 0.001). Blood glucose level was found to be increased after addition of salt. Serum ALT and AST level was significantly higher in fermented P. sophore after comparison with the standard diet with olive oil (##p < 0.001, **p < 0.01 As compared with standard diet with olive oil). The serum LDH level was significantly higher in salted T. Ilisha and sun-dried M. bleekeri **p < 0.01 (As compared with standard diet with olive oil). Through the estimation of liver component, it was observed that total cholesterol content was found to be significantly higher in sun-dried P. sophore than the standard diet of olive oil (#p < 0.01 As compared with the standard diet of olive oil).
Conclusion
Comparing all atherosclerotic parameters, liver and plasma component of fresh and processed fish samples with standard diet of olive oil the present experiment revealed that, oil from fresh sample may be considered safe for human health.