bluuebunny/crossref_metadata_2025_split huggingface dataset:
(e) in Normandy: The sociolinguistics, phonology and phonetics of theLoi de Position
Authors: HALL DAMIEN 
Published: August 2018

ABSTRACTThis article uses the pronunciation of stressed Intonational Phrase-final /ε/ and /e/ in two communities in Normandy, France, to illustrate the convergence of two sociolinguistic processes on the same phonological result: increasing application of theLoi de Position. In both communities (one rural and further from Paris, one urban and closer to Paris), there is now no consistent community-wide phonetic distinction between the two phonemes in that environment. It is suggested that theLoi de Positionis already widely applied in the rural site, but speakers are still conscious of the formal norm whereby it is not applied; for the urban site, apparent-time changes for this variable reflect changes in Parisian speech. The theoretical implications of the study concerning speakers’ organisation of their vowel-space, and concerning the increasing application of theLoi de Positionin the French of France, are examined. These conclusions are reached by per-speaker analysis of F1 and F2 separately from each other (rare in French linguistics). As a measure of community cohesion, the article introduces to linguistics the coefficient of variation (more common in biology and medicine).
Recognizable languages of arrows and cospans
Authors: BRUGGINK H. J. SANDER , KÖNIG BARBARA 
Published: August 2018

In this article, we generalize Courcelle's recognizable graph languages and results on monadic second-order logic to more general structures.First, we give a category-theoretical characterization of recognizability. A recognizable subset of arrows in a category is defined via a functor into the category of relations on finite sets. This can be seen as a straightforward generalization of finite automata. We show that our notion corresponds to recognizable graph languages if we apply the theory to the category of cospans of graphs.In the second part of the paper, we introduce a simple logic that allows to quantify over the subobjects of a categorical object. Again, we show that, for the category of graphs, this logic is equally expressive as monadic second-order graph logic (msogl). Furthermore, we show that in the more general setting of hereditary pushout categories, a class of categories closely related to adhesive categories, we can recover Courcelle's result that everymsogl-expressible property is recognizable. This is done by giving an inductive translation of formulas of our logic into automaton functors.
Lamotrigine-induced obsessive-compulsive disorder in patients with bipolar disorder
Authors: Sharma Verinder , Doobay Minakshi 
Published: August 2018

IntroductionLamotrigine is a commonly used drug in the treatment of bipolar disorder. Although there are reports of its effectiveness in the management of bipolar disorder and comorbid obsessive-compulsive disorder (OCD), lamotrigine has also been associated with obsessionality in patients with bipolar disorder.MethodsCharts of 8 patients with bipolar disorder who had de novo onset of obsessions and compulsions after the use of lamotrigine were reviewed. The Naranjo scale was used to assess the likelihood of patients developing OCD due to lamotrigine use.ResultsTwo to 8 months after the initiation of lamotrigine, patients with no such prior history developed obsessions and compulsions meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria for medication-induced OCD. In all except 1 patient, the symptoms resolved within a month of lamotrigine discontinuation.ConclusionsSome patients with bipolar disorder may develop OCD after initiation of lamotrigine. Due to the inherent limitations of a case series, the findings should be interpreted with caution.
A SIMULATION STUDY OF TEXAS HOLD ’EM POKER: WHAT TAYLOR SWIFT UNDERSTANDS AND JAMES BOND DOESN’T
Authors: FALLETTA J. , WOODCOCK S. 
Published: August 2018

Recent years have seen a large increase in the popularity of Texas hold ’em poker. It is now the most commonly played variant of the game, both in casinos and through online platforms. In this paper, we present a simulation study for games of Texas hold ’em with between two and 23 players. From these simulations, we estimate the probabilities of each player having been dealt the winning hand. These probabilities are calculated conditional on both partial information (that is, the player only having knowledge of his/her cards) and also on fuller information (that is, the true probabilities of each player winning given knowledge of the cards dealt to each player). Where possible, our estimates are compared to exact analytic results and are shown to have converged to three significant figures.With these results, we assess the poker strategies described in two recent pieces of popular culture. In comparing the ideas expressed in Taylor Swift’s song, New Romantics, and the betting patterns employed by James Bond in the 2006 film, Casino Royale, we conclude that Ms Swift demonstrates a greater understanding of the true probabilities of winning a game of Texas hold ’em poker.
Nurses’ Intention to Leave the Organization: A Mediation Study of Professional Burnout and Engagement
Authors: Marques-Pinto Alexandra , Jesus Élvio Henriques , Mendes Aida Maria Oliveira Cruz , Fronteira Inês , Roberto Magda Sofia 
Published: August 2018

AbstractThe nature of the turnover process calls for the study of more complex relationships among variables beyond simple bivariate or multiple associations between predictors and turnover intentions. The present article aims to examine the predictive value of job demands and resources in the explanation of nurses’ intention to leave the organization and to test the mediating roles of professional burnout and engagement in these relationships, within a Portuguese nursing population. The research models were tested within the scope of the Registered Nurse Forecasting project. Data included the self-report questionnaires of 2,235 Portuguese nurses from 31 hospitals, collected through stratified random sampling procedures. The statistical analyses of the structural models showed that nurses’ participation in hospital affairs, a job resource at the work organization level, was the only significant predictor of nurses´ intention to leave the organization (β=–.45,p< .001). Analyses of the mediation models revealed that the emotional exhaustion symptoms of burnout (β= –.11,p< .001) and job engagement feelings (β= –.15,p< .001) were both significant mediators between nurses’ decisional involvement and their intentions to leave the organization. Results suggest that including nurses in decision-making processes regarding their professional practice policy and environment, and improving nurses’ professional well-being are two crucial strategies to reduce nurses’ turnover intentions.
Perceptual-Motor Maturity in Adolescence and the Tanner Stages: A Study with Bender-Gradual Scoring System
Authors: de Freitas Keppeke Livia , Schoen Teresa Helena 
Published: August 2018

AbstractVisual-motor skill forms an important psycho diagnostic component and is associated with psycho-neurological aspects. The Bender Visual-Motor Gestalt Test, widely used for the evaluation of this area, is meant for children up to 11 years. In adolescence, the changes associated with puberty generate nonlinear anthropometric development resulting in mild and temporary incoordination. This study investigated the relation between visual-motor development measured by the Bender test and pubertal changes according to the Tanner scale. In all 134 adolescents of both sexes, aged from 10 to 15, who kept routine medical appointments, participated. We used the Bender Visual-Motor Gestalt Test, Raven’s Progressive Matrices Test, and medical chart data. The techniques were applied individually. Pubertal changes were associated with the Bender test results showing higher scores at the G3 stage, the period corresponding to a growth spurt, compared to the G5 stage (p= .007, ES = .187), the post-growth spurt period in boys. Age and gender did not influence the Bender test scores. According to the Raven test, thegintelligence factor, interfered significantly in the visual-motor performance (r =–57%,p< .001). Schooling, repetition of a school year, and developmental problems (p= .002, ES = .156;p= .002, ES = .623;p< .001, ES = .880, respectively) obtained similar results. The Bender Test was sensitive to schooling and maturational problems during adolescence. There was an association between visual-motor development and sexual maturity in male adolescents. Our results indicate the usefulness of the Bender Test at older ages than those used in the test standardization.
Facebook: Risks and Opportunities in Brazilian and Portuguese Youths with Different Levels of Psychosocial Adjustment
Authors: Marques Teresa Paula , Marques-Pinto Alexandra , Alvarez Maria-João , Pereira Cícero Roberto 
Published: August 2018

AbstractThis study aimed to assess the risks and opportunities associated with Facebook usage and to explore the moderating role of psychosocial (mal)adjustment, nationality and age in these relationships. This correlational study involved a sample of 452 Brazilian and 500 Portuguese youths, aged between 14 and 20 years. Results showed that these youths spent a daily average of 61-120 minutes on Facebook, three to four times per week, displaying a positive attitude towards its use. These characteristics were most notable in the Brazilian youths [t(950) = 5.64, p < .001; t(950) = –5.07, p < .001; and t(950) = – 6.85, p < .001, respectively]. The Portuguese youths ran more risks than the Brazilians [t(950) = 6.36, p < .001], but both youths equally enjoyed the opportunities. In the case of the Portuguese youths, the risks and opportunities were moderated by the frequency of use, in other words “the higher the usage, the more risks and opportunities” (β = –.235 p < .001and β = –.167, p < .001, respectively). The psychosocial adjustment indicators did not moderate the effects of Facebook usage habits in risks and opportunities. The less psychosocially adjusted youths were those who ran more risks and also made the most of the opportunities. The results are discussed in light of the role of psychological, socio-cultural and developmental factors.
Statistical Analysis of the Phase Velocity Distribution of Mesospheric and Ionospheric Waves Observed in Airglow Images Over a 16‐Year Period: Comparison Between Rikubetsu and Shigaraki, Japan
Authors: Tsuchiya Satoshi , Shiokawa Kazuo , Fujinami Hatsuki , Otsuka Yuichi , Nakamura Takuji , Yamamoto Mamoru 
Published: August 2018

AbstractAtmospheric gravity waves (AGWs) in the mesopause region and medium‐scale traveling ionospheric disturbances (MSTIDs) in the thermosphere from 1999 through 2014 were studied by applying a three‐dimensional spectral analysis technique to airglow images at wavelengths of 557.7 (emission altitudes: 90–100 km) and 630.0 nm (emission altitudes: 200–300 km) obtained at Rikubetsu (43.5°N, 143.8°E) and Shigaraki (34.8°N, 136.1°E), Japan. To our knowledge, such a long‐term multipoint analysis of AGWs and MSTIDs using airglow images has not been reported previously. The propagation direction of mesospheric AGWs seen in 557.7‐nm airglow images at both stations was northeastward in summer and southwestward in winter, probably due to wind filtering of these waves by the mesospheric jet. In winter, the propagation direction of AGWs shifted from southwestward to northwestward as time progressed from evening to morning at both stations, which can also be explained by the wind filtering effect. The propagation direction of AGWs changed from southwestward to northeastward at Rikubetsu during a zonal wind reversal at 60°N at 10 hPa, caused by stratospheric sudden warming (SSW). No such a SSW‐associated change was identified at Shigaraki, indicating that the effect of SSW wind reversal reached only the Rikubetsu latitudes. For MSTIDs, the major propagation direction was southwestward with a minor northeastward peak for all seasons at both stations. A negative correlation was found between the yearly variation in power spectral density and solar F10.7 flux. This negative correlation can be explained by considering the linear growth rate of the Perkins instability.
Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins
Authors: Ismaylova Elmira , Lévesque Melissa L. , Pomares Florence B. , Szyf Moshe , Nemoda Zsofia , Fahim Cherine , Vitaro Frank , Brendgen Mara , Dionne Ginette , Boivin Michel , Tremblay Richard E. , Booij Linda 
Published: August 2018

AbstractSeveral studies have examined associations between peripheral DNA methylation patterns of the serotonin transporter gene (SLC6A4) promoter and symptoms of depression and anxiety. The SLC6A4 promoter methylation has also been associated with frontal-limbic brain responses to negative stimuli. However, it is unclear how much of this association is confounded by DNA sequence variations. We utilized a monozygotic-twin within-pair discordance design, to test whether DNA methylation at specific CpG sites in the SLC6A4 promoter of peripheral cells is associated with greater frontal-limbic brain responses to negative stimuli (sadness and fear), independently of DNA sequence effects. In total 48 pairs of healthy 15-year-old monozygotic twins from the Quebec Newborn Twin Study, followed regularly since birth, underwent functional magnetic resonance imaging while conducting an emotion-processing task. The SLC6A4 promoter methylation level was assessed in saliva samples using pyrosequencing. Relative to the co-twins with lower SLC6A4 promoter methylation levels, twins with higher peripheral SLC6A4 methylation levels showed greater orbitofrontal cortical (OFC) activity and left amygdala-anterior cingulate cortex (ACC) and left amygdala-right OFC connectivity in response to sadness as well as greater ACC-left amygdala and ACC-left insula connectivity in response to fearful stimuli. By utilising a monozygotic-twin design, we provided evidence that associations between peripheral SLC6A4 promoter methylation and frontal-limbic brain responses to negative stimuli are, in part, independent of DNA sequence variations. Although causality cannot be determined here, SLC6A4 promoter methylation may be one of the mechanisms underlying how environmental factors influence the serotonin system, potentially affecting emotional processing through frontal-limbic areas.
Investigating the genetic architecture of general and specific psychopathology in adolescence
Authors: Jones Hannah J. , Heron Jon , Hammerton Gemma , Stochl Jan , Jones Peter B. , Cannon Mary , Smith George Davey , Holmans Peter , Lewis Glyn , Linden David E. J. , O’Donovan Michael C. , Owen Michael J. , Walters James , Zammit Stanley ,   the 23 and Me Research Team
Published: August 2018

AbstractWhilst associations between polygenic risk scores (PRSs) for schizophrenia and various phenotypic outcomes have been reported, an understanding of developmental pathways can only be gained by modelling comorbidity across psychopathology. We examine how genetic risk for schizophrenia relates to adolescent psychosis-related and internalizing psychopathology using a latent modelling approach, and compare this to genetic risk for other psychiatric disorders, to gain a more comprehensive understanding of the developmental pathways at this age. PRSs for schizophrenia, major depressive disorder, neuroticism and bipolar disorder were generated for individuals in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Multivariate linear regression was used to examine the relationships of these PRSs with psychopathology factors modelled within (i) a correlated factors structure and (ii) a bifactor structure. The schizophrenia PRS was associated with an increase in factors describing psychotic experiences, negative dimension, depression and anxiety, but, when modelling a general psychopathology factor based on these measures, specific effects above this persisted only for the negative dimension. Similar factor relationships were observed for the neuroticism PRS, with a (weak) specific effect only for anxiety once modelling general psychopathology. Psychopathology during adolescence can be described by a general psychopathology construct that captures common variance as well as by specific constructs capturing remaining non-shared variance. Schizophrenia risk genetic variants identified through genome-wide association studies mainly index negative rather than positive symptom psychopathology during adolescence. This has potentially important implications both for research and risk prediction in high-risk samples.
Flux-dependent graphs for metabolic networks
Authors: Beguerisse-Díaz Mariano , Bosque Gabriel , Oyarzún Diego , Picó Jesús , Barahona Mauricio 
Published: August 2018

AbstractCells adapt their metabolic fluxes in response to changes in the environment. We present a framework for the systematic construction of flux-based graphs derived from organism-wide metabolic networks. Our graphs encode the directionality of metabolic flows via edges that represent the flow of metabolites from source to target reactions. The methodology can be applied in the absence of a specific biological context by modelling fluxes probabilistically, or can be tailored to different environmental conditions by incorporating flux distributions computed through constraint-based approaches such as Flux Balance Analysis. We illustrate our approach on the central carbon metabolism of Escherichia coli and on a metabolic model of human hepatocytes. The flux-dependent graphs under various environmental conditions and genetic perturbations exhibit systemic changes in their topological and community structure, which capture the re-routing of metabolic flows and the varying importance of specific reactions and pathways. By integrating constraint-based models and tools from network science, our framework allows the study of context-specific metabolic responses at a system level beyond standard pathway descriptions.
REST overexpression in mice causes deficits in spontaneous locomotion
Authors: Lu Li , Marisetty Anantha , Liu Bin , Kamal Mohamed Mostafa , Gumin Joy , Veo Bethany , Cai YouQing , Kassem Dina Hamada , Weng Connie , Maynard Mark E. , Hood Kimberly N. , Fuller Gregory N. , Pan Zhizhong Z. , Cykowski Matthew D. , Dash Pramod K. , Majumder Sadhan 
Published: August 2018

AbstractOverexpression of REST has been implicated in brain tumors, ischemic insults, epilepsy, and movement disorders such as Huntington’s disease. However, owing to the lack of a conditional REST overexpression animal model, the mechanism of action of REST overexpression in these disorders has not been established in vivo. We created a REST overexpression mouse model using the human REST (hREST) gene. Our results using these mice confirm that hREST expression parallels endogenous REST expression in embryonic mouse brains. Further analyses indicate that REST represses the dopamine receptor 2 (Drd2) gene, which encodes a critical nigrostriatal receptor involved in regulating movement, in vivo. Overexpression of REST using Drd2-Cre in adult mice results in increased REST and decreased DRD2 expression in the striatum, a major site of DRD2 expression, and phenocopies the spontaneous locomotion deficits seen upon global DRD2 deletion or specific DRD2 deletion from indirect-pathway medium spiny neurons. Thus, our studies using this mouse model not only reveal a new function of REST in regulating spontaneous locomotion but also suggest that REST overexpression in DRD2-expressing cells results in spontaneous locomotion deficits.
Mid-and long-term efficacy of endovascular-based procedures for Cockett syndrome
Authors: Xu Jiasheng , Liu Yujun , Zhou Weimin 
Published: August 2018

AbstractTo investigate the mid- and long-term results of endovascular-based procedures for Cockett syndrome. The clinical data of 412 patients with Cockett syndrome treated between January 2003 and September 2017 were retrospectively analyzed. In these patients, 231 cases were acute left iliac femoral vein thrombosis (group A), and 181 cases were chronic venous insufficiency (group B), and different endovascular procedures and/or hybrid procedures were performed. In group A, the technique success rate was 100% (231/231); the left iliac vein in 5 patients showed no stenosis or occlusion, and the incidence of pathological changes in the left iliac vein was 97.8% (226/231); a total of 182 stents were implanted. In group B, the technique success rate was 99.4% (180/181); the average pressure difference between the proximal and distal portion of the pathological left iliac veins decreased from preoperative (18 ± 4.45) cmH2O to postoperative (4 ± 3.02) cmH2O (P < 0.01); 89 patients, complicated with valvular incompetence in the left superficial femoral vein, underwent a second-stage femoral valve repair. Follow-up ranged from 3 months to 8 years, with an average of 35.6 months, and intrastent thrombosis occurred in 15 cases of group A and in 2 cases of group B. Endovascular-based procedures offer favorable mid- and long-term results in treatment of Cockett syndrome, which in combination with Fogarty catheter thrombectomy or catheter-directed thrombolysis is a beneficial complementary treatment for patients with acute iliac femoral vein thrombosis.
Gene Ontology Enrichment Improves Performances of Functional Similarity of Genes
Authors: Liu Wenting , Liu Jianjun , Rajapakse Jagath C. 
Published: August 2018

AbstractThere exists a plethora of measures to evaluate functional similarity (FS) between genes, which is a widely used in many bioinformatics applications including detecting molecular pathways, identifying co-expressed genes, predicting protein-protein interactions, and prioritization of disease genes. Measures of FS between genes are mostly derived from Information Contents (IC) of Gene Ontology (GO) terms annotating the genes. However, existing measures evaluating IC of terms based either on the representations of terms in the annotating corpus or on the knowledge embedded in the GO hierarchy do not consider the enrichment of GO terms by the querying pair of genes. The enrichment of a GO term by a pair of gene is dependent on whether the term is annotated by one gene (i.e., partial annotation) or by both genes (i.e. complete annotation) in the pair. In this paper, we propose a method that incorporate enrichment of GO terms by a gene pair in computing their FS and show that GO enrichment improves the performances of 46 existing FS measures in the prediction of sequence homologies, gene expression correlations, protein-protein interactions, and disease associated genes.