bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary Report on Unique Laminated Holocene Sediments from the Qarun Lake in Egypt
Authors: Marks Leszek , Salem Alaa , Welc Fabian , Nitychoruk Jerzy , Chen Zhongyuan , Zalat Abdelfattah , Majecka Aleksandra , Chodyka Marta , Szymanek Marcin , Tołoczko-Pasek Anna 
Published: May 2018

Abstract
The Lake Qarun (Faiyum Oasis, northern Egypt) is a relic of the much larger Holocene lake. Past lake levels and extensions were reconstructed, based on setting of archaeological sites scattered along northern paleoshores of the ancient lake. However, geoarcheological works did not yield enough data to establish continuous environmental history of the lake. A deep drilling FA-1 on the southeastern shore of the lake, performed in 2014, supplied with a core, 26 m long that is the one of the longest lake sediment cores in northeastern Africa. The basal section of the core consisted of thin-laminated diatom marly deposits, underlain at the Late Pleistocene/Holocene boundary by coarse-grained sands. The sediment lamine were quite well developed, especially in the lower part of the core. Preliminary results indicated annually deposited sediment sequence with seasonality signals provided by microlamine of diatoms, calcite, organic matter and clastic material. Early Holocene varved sediments from the Faiyum Oasis supplied with exceptional paleoenvironmental data for northeastern Africa, which enriched a record from previous logs drilled at the southwestern margin of the Qarun Lake.
Paleoclimatological and Geoarchaeological Significance of the Holocene Loess – Soil Successions of the Tien Shan Foothills of Uzbekistan
Authors: Welc Fabian , Toychiew Khodjiakbar , Suska-Malawska Małgorzata , Marks Leszek , Mętrak Monika 
Published: May 2018

AbstractScenario of climate changes in the Late Pleistocene and Holocene in Central Asia is very fragmentary and inconsistent. Therefore, interaction between the development and decline of ancient cultures and the climate fluctuations are difficult to be traced. To resolve this problem, the key role can be played by multidisciplinary studies of unique Late Pleistocene and especially Holocene loess – soil succession of the Tien Shan foothills in Uzbekistan. This area yields unique successions of paleosols interbedded with loesses that are particularly useful for paleoclimate analysis. They are represented by continuous and uninterrupted sedimentary sequences with a highly varied record of magnetic susceptibility. As such, they contain a full sequence of short-term climatic oscillations of the Holocene in high resolution and therefore, in this case, they are exceptional on global scale. The correlation of Late Pleistocene and Holocene climate changes scenario with stages of development and collapse of the past human settlement in Central Asia seems at present one of the most promising research directions, in line with the substantial course of interdisciplinary research on the interaction between humans and the natural environment.
GAD65 Promoter Polymorphism rs2236418 Modulates Harm Avoidance in Women via Inhibition/Excitation Balance in the Rostral ACC
Authors: Colic Lejla , Li Meng , Demenescu Liliana Ramona , Li Shija , Müller Iris , Richter Anni , Behnisch Gusalija , Seidenbecher Constanze I. , Speck Oliver , Schott Björn H. , Stork Oliver , Walter Martin 
Published: May 2018

Anxiety disorders are common and debilitating conditions with higher prevalence in women. However, factors that predispose women to anxiety phenotypes are not clarified. Here we investigated potential contribution of the single nucleotide polymorphism rs2236418 inGAD2gene to changes in regional inhibition/excitation balance, anxiety-like traits, and related neural activity in both sexes. One hundred and five healthy individuals were examined with high-field (7T) multimodal magnetic resonance imaging (MRI); including resting-state functional MRI in combination with assessment of GABA and glutamate (Glu) levels via MR spectroscopy. Regional GABA/Glu levels in anterior cingulate cortex (ACC) subregions were assessed as mediators of gene–personality interaction for the trait harm avoidance and moderation by sex was tested. In AA homozygotes, with putatively lowerGAD2promoter activity, we observed increased intrinsic neuronal activity and higher inhibition/excitation balance in pregenual ACC (pgACC) compared with G carriers. The pgACC drove a significant interaction of genotype, region, and sex, where inhibition/excitation balance was significantly reduced only in female AA carriers. This finding was specific for rs2236418 as other investigated single nucleotide polymorphisms of the GABA synthesis related enzymes (GAD1,GAD2, andGLS) were not significant. Furthermore, only in women there was a negative association of pgACC GABA/Glu ratios with harm avoidance. A moderated-mediation model revealed that pgACC GABA/Glu also mediated the association between the genotype variant and level of harm avoidance, dependent on sex. Our data thus provide new insights into the neurochemical mechanisms that control emotional endophenotypes in humans and constitute predisposing factors for the development of anxiety disorders in women.SIGNIFICANCE STATEMENTAnxiety disorders are among the most common and burdensome psychiatric disorders, with higher prevalence rates in women. The causal mechanisms are, however, poorly understood. In this study we propose a neurobiological basis that could help to explain female bias of anxiety endophenotypes. Using magnetic resonance brain imaging and personality questionnaires we show an interaction of the genetic variation rs2236418 in theGAD2gene and sex on GABA/glutamate (Glu) balance in the pregenual anterior cingulate cortex (pgACC), a region previously connected to affect regulation and anxiety disorders. TheGAD2gene polymorphism further influenced baseline neuronal activity in the pgACC. Importantly, GABA/Glu was shown to mediate the relationship between the genetic variant and harm avoidance, however, only in women.
High-Amplitude Circadian Rhythms in Drosophila Driven by Calcineurin-Mediated Post-translational Control of sarah
Authors: Kweon Sin Ho , Lee Jongbin , Lim Chunghun , Choe Joonho 
Published: May 2018

Abstract
Post-translational control is a crucial mechanism for circadian timekeeping. Evolutionarily conserved kinases and phosphatases have been implicated in circadian phosphorylation and the degradation of clock-relevant proteins, which sustain high-amplitude rhythms with 24-hr periodicity in animal behaviors and physiology. Here, we report a novel clock function of the heterodimeric Ca2+/calmodulin-dependent phosphatase calcineurin and its regulator sarah (sra) in Drosophila. Genomic deletion of the sra locus dampened circadian locomotor activity rhythms in free-running constant dark after entrainment in light–dark cycles. Poor rhythms in sra mutant behaviors were accompanied by lower expression of two oscillating clock proteins, PERIOD (PER) and TIMELESS (TIM), at the post-transcriptional level. RNA interference-mediated sra depletion in circadian pacemaker neurons was sufficient to phenocopy loss-of-function mutation in sra. On the other hand, a constitutively active form of the catalytic calcineurin subunit, Pp2B-14DACT, shortened circadian periodicity in locomotor behaviors and phase-advanced PER and TIM rhythms when overexpressed in clock neurons. Heterozygous sra deletion induced behavioral arrhythmicity in Pp2B-14DACT flies, whereas sra overexpression rescued short periods in these animals. Finally, pharmacological inhibition of calcineurin in either wild-type flies or clock-less S2 cells decreased the levels of PER and TIM, likely by facilitating their proteasomal degradation. Taken together, these data suggest that sra negatively regulates calcineurin by cell-autonomously titrating calcineurin-dependent stabilization of PER and TIM proteins, thereby sustaining high-amplitude behavioral rhythms in Drosophila.
MORPHOLOGICAL STRUCTURE OF LATE RENAL GRAFT DYSFUNCTION AND ITS EFFECT FOR LONG-TERM RESULTS
Authors: Stolyarevich E. S. , Zhilinskaya T. R. , Artyukhina L. Yu. , Kim I. G. , Zaydenov V. A. , Tomilina N. A. 
Published: April 2018

Aim:to analyze the frequency of different histological diagnoses and it simpact on graft survival in a cohort of patients with renal allograft dysfunction, and to determine pathology features, infl uencing prognosis.Materials and methods.The data obtained from 1470 biopsies, performed by indication at different time after kidney transplantation (48.8 ± 46.1 months) were analyzed retrospectively according to the Banff 2013 classifi cation. Results.The majority of graft dysfunction episodes were attributed to fi ve causes: acute (26,8%) and chronic (12,4%) rejection; chronic nephrotoxicity of СNI (19,3%), interstitial fi brosis/tubular atrophy (15,8%) and recurrent or de novo glomerulonephritis (10,6%). T-cell-mediated acute rejection and functional disorders were the most often cause of dysfunction during the fi rst year after transplantation (40,5% and 21% respectively) but decreased over time. On the other hand, the frequency of chronic rejection, interstitial fi brosis/tubular atrophy with or without СNI nephrotoxicity and recurrent or de novo glomerulonephritis increased from 13%, 26% and 5,5% at the fi rst year to 26,4%, 35,3% and 22,8% respectively at 8 year after transplantation. Chronic rejection represented a major risk for graft loss – 8-year graft survival did not exceed 5%. The prognosis of acute rejection as well asde novoor recurrent glomerular pathologies was more favorable (38% and 42% respectively). In cases of interstitial fi brosis/tubular atrophy with or without СNI nephrotoxicity 8-year graft survival was slightly lower than in the functional disorders (62% and 76%). In acute rejection prognosis for C4d-positive forms was worse compared to C4d-negative, while in chronic rejection there was no difference between C4d-positive and C4d-negative forms. The features of СNI nephrotoxicity did not infl uence the prognosis of non-specifi c interstitial fi brosis and tubular atrophy.Conclusion.Transplant pathology in patients with allograft dysfunction is heterogeneous and changes over time. Acute and chronic rejection; interstitial fi brosis/tubular atrophy with or without СNI nephrotoxicity and recurrent/de novoglomerular pathology are the most often causes of graft dysfunction, but only rejection (mostly chronic) and glomerular pathology are associated with unfavorable prognosis.
RESULTS OF KIDNEY TRANSPLANTATION IN AKTOBE REGION OF KAZAKHSTAN
Authors: Kaliyev A. A. , Zhakiyev В. S. , Sultangereyev E. В. , Rysmakhanov M. S. , Elemesov A. A. , Almyrzauly Zh. , Ermagambetov K. K. 
Published: April 2018

Aim:to analyse the results of the initial experience of kidney transplantation of the regional hospital of the Republic of Kazakhstan.Materials and methods.The results of kidney transplantations which were performed to 31 patients in the Aktobe Medical Center (AMC, Aktobesity) for the period from November 2014 to 2017 are presented. Kidney transplantations were performed in compliance with clinical protocols according to the generally accepted methodology. In 25 cases transplantation performed from a living donor, in 6 cases – from deceased donors. The most of living donors underwent laparoscopic nephroureterectomy with manual assistance (70.8%).Results.After nephrectomy operations complications were not observed in donors, all patients were discharged in a satisfactory state on the 5th–8th postoperative day. The following complications were observed in recipients in the early postoperative period: acute tubular necrosis – 1, postoperative bleeding (retroperitoneal hematoma) – 2, lymphorrhagia – 2, urinary leakages – 2. One recipient was died in the late postoperative period after infection complications and the development of sepsis.Conclusions.Kidney transplantation is undoubtedly effective method for treating patients with terminal chronic kidney failure. The results of the initial experience of kidney transplantation in the Aktobe regional hospital of the Republic of Kazakhstan are not differ from the average results of leading domestic and other foreign transplant clinics.
Интерпретации культуры в контексте мифа
Authors: Флиер Андрей Яковлевич 
Published: April 2018

<p>В статье представлена анализ миф и мифологии как системообразующего контекста актуальной интерпретации культуры, как распространенная форма массового сознания.</p><p>Текст доклада автора на Всероссийской научной конференции «Культура между Логосом и Мифом: к проблеме бессознательного (к 80-летию А. Э. Воскобойникова)», которая прошла в Московском гуманитарном университете 26-27 октября 2017 года.</p>
К вопросу о качестве российской постсоветской философии
Authors: Дружинин Виктор Федорович 
Published: April 2018

<p>В статье автор размышляет о новом качестве современной российской философии, о проблемах, которые стоят перед ней и о миссии философов.</p><p>Текст доклада автора на Всероссийской научной конференции «Культура между Логосом и Мифом: к проблеме бессознательного (к 80-летию А. Э. Воскобойникова)», которая прошла в Московском гуманитарном университете 26-27 октября 2017 года.</p>
Laparoskopik sleeve gastrektomide stapler hattında uygulanan barbed sütur ve fibrin adhezivlerin etkisinin kıyaslanması: retrospektif çalışma
Authors: YORMAZ Serdar , ECE İlhan , ÇOLAK Bayram , YILMAZ Hüseyin , ALPTEKİN Hüsnü , ACAR Fahrettin , KAFALI M. Ertugrul , ŞAHİN Mustafa 
Published: April 2018

Amaç:Araştırmamızda morbid obezite nedeniyle
laparoskopik sleeve gastrektomi uygulanan ve stapler hattına destek süturu
konan veya fibrin adheziv kullanılan hastaların sonuçlarını değerlendirmeyi
amaçladık.Gereç ve Yöntem:Bariatrik cerrahi kliniğimizde mayıs 2014 ile
temmuz 2016 tarihleri arasında morbid obezite nedeniyle laparoskopik sleeve
gastrektomi uygulanan ve stapler hattına sütur konan ve adheziv konan 86
hasta retrospektif olarak incelendi.
Hasta profilinin demografik bulguları, operasyon süreleri, komplikasyon
tipleri, oranları, hastanede kalış süreleri
değerlendirildi. Çalışma grubumuzdaki hastalar vücut kitle indeksi, yaş,
cinsiyet ve sayı açısından benzerlik olduğu için randomize olarak kabul
edildiler. İstatistiksel olarak anlamlı sonuçlar p&lt;0.05 olarak kabul edildi.Bulgular:Çalışmaya katılan hastaların ortalama yaşı
37.12±5.51 (yaş aralığı 23–57), ortalama VKİ 46.3±4.7 kg/m2 (aralığı
41–59) idi. Ortalama ameliyat süresi 87.9±16.1 dakika olarak hesaplandı.
Operasyonun ortalama süresi 72.5 ±12.7 dakika (25–102 dakika aralığı) idi.
Postoperatif dönemde ortalama hastanede kalış süresi ise 5.23±1.22 gün (3–8gün
aralığı) olarak bulundu. Ameliyat sonrası 4 hastada komplikasyon gelişirken,
herhangi bir hastada majör komplikasyon veya mortalite görülmedi.
Operasyonların hepsi laparoskopik olarak sonlandırıldı.Sonuç: Bariatrik cerrahide
staplerle uygulanan obezite cerrahisinde stapler hattının özellikle barbed
sütur ile desteklenmesi operasyonun güvenilirliğini artırıp komplikasyon
oranını azaltmaktadır.
Emergency peripartum hysterectomy and its association with cesarean section: a 3 years retrospective study
Authors: Kaur Harpreet , Kaur Balpreet , Kaur Sarvjeet 
Published: April 2018

Background: Emergency peripartum hysterectomy refers to the abdominal hysterectomy performed during or immediately after cesarean section or vaginal delivery, in a setting of life threatening haemorrhage. Over the past two decades, incidence of cesarean section has greatly increased which emerges as one of the cause for abnormal placentation in subsequent pregnancies thus resulting in increased incidence of haemorrhage. The unplanned nature of the surgery and acute blood loss renders the patient in a less than ideal situation to undergo such a dramatic surgery. Evaluation of risk factors, adequate resuscitation, involvement of senior obstetrician and timely decision for EPH in cases of refractory peripartum haemorrhage would help in significantly reducing the maternal mortality and morbidity. Objective was to study the association between cesarean section and emergency peripartum hysterectomy. Methods: It is a retrospective study of all women who had undergone emergency peripartum hysterectomy between January 2015 to January 2018 in the Department of Obstetrics and Gynaecology, Guru Gobind Singh Medical College, Faridkot. Incidence, indications, risk factors and complications of emergency peripartum hysterectomies (EPH) were recorded.Results: During three years period the overall incidence of EPH was 1.85 per 1000 deliveries.Conclusions: Emergency peripartum hysterectomy is a challenging procedure performed in obstetrics when all other conservative methods to control uterine haemorrhage have failed. With increased incidence of cesarean sections the cause of emergency peripartum hysterectomy has greatly shifted from uterine atony to abnormal placentation. Abnormal placentation has now become the most commonly associated indication for EPH. Recognising and assessing patients at risk with appropriate and timely intervention would help in ensuring a better outcome in this otherwise difficult situation.
Caesarean scar ectopic pregnancy
Authors: Devi T. Ramani , Sweta T. , Devi C. Archana 
Published: April 2018

Ectopic pregnancy is a common cause of mortality and morbidity among the women of reproductive age group. Tubal pregnancy is the commonest. It can occur in cervix, ovaries, previous caesarean scar, interstitial portion of the tube and abdominal cavity. Here we report a case of caesarean scar ectopic pregnancy which was managed conservatively. 31 yrs old gravid 3 previous 1 LSCS and 1 tubal ectopic come for antenatal consultation at 35 days of gestation. UPT was Positive. USG showed no evidence of intra uterine sac. Repeat scan after 10 days showed a gestational sac at the lower uterine segment scar. Hence it was decided for conservative management, injection methotrexate 50 mgm X 2 doses given. This was followed by misoprost vaginal insertion. Since patient did not expel the sac, injection PG F2 alpha 125 mg x 2 doses were given. Patient expelled the products of conception partially. This was followed by hysteroscopic guided evacuation.Caesarean scar ectopic was reported in 1978. Early diagnosis is by TV USG / MRI. Early ectopic can be treated medically. In delayed diagnosis, laparoscopic excision of the scar has to be done. In rupture of the scar site ectopic pregnancy laparotomy is indicated. In the event of heavy bleeding, hysterectomy has to be done. After conservative management and excision of the scar, fertility is not altered. Caesarean section scar pregnancy is a rare form of ectopic pregnancy which can lead to life threatening complications leading to mortality and morbidity. Treatment has to be individualized according to the gestational age, haemodynamic stability and desire for future fertility.
A case series of craniotomy in obstetric patients: a lifesaving treatment modality
Authors: Subha S. S. , Dhanapal Mohana , . Aiswary 
Published: April 2018

BACKGROUND:Neurosurgical disorders are a significant cause of non-obstetric death and disability in pregnant women. They pose a unique therapeutic challenge. The changes in normal physiology during pregnancy add to the complexity of management. The common conditions encountered are intracranial hemorrhage, tumours, trauma and spinal pathologies. It is preferrable to wait until the third trimester if the indication is semi-elective.MATERIALS AND METHODS: Here we present a prospective study of four cases , managed with neurosurgery in pregnancy and puerperium.RESULTS: Of the 4 cases two cases were craniotomy done for cortical vein thrombosis and two cases of excision of space occupying lesions. CONCLUSIONS: Pregnancy itself should not be considered a contra-indication to neurosurgery, which when considered early in some patients, proves to be life-saving.
ANALYSIS INDICATOR OF FACTORS AFFECTING HUMAN DEVELOPMENT INDEX (IPM)
Authors: Lestari Windya Wahyu , Sanar Victoria Efrida 
Published: May 2018

The purpose of this study is to determine how big the influence of the indicators of factors that affect the Human Development Index. In addition, to determine the relationship of indicators of factors that affect the Human Development Index, to determine the development of human development of variables. That way can provide a standard against a State in improving the quality of human resources. Using the SPSS application method, this paper found that the variables that significantly influence the indicators of factors affecting the Human Development Index are life expectancy index, education index and income index. The estimation result using Correlasion Pearson shows that 14.788% is the variation of each observation is the same.

Keywords : Human Development Index, Life Expectancy Index, Education Index, Revenue Index.
Pre-Service Science Teachers' Perception About High Order Thinking Skills (HOTS) in the 21st Century
Authors: Afandi Afandi , Sajidan Sajidan , Akhyar Muhammad , Suryani Nunuk 
Published: May 2018

In the 21<sup>st</sup> century, the pre-service science teachers faced on extremely global competitiveness, globalization, technologically driven by information and rapidly media-saturated that needs appropriate skills to meet these challenges. The aims of this study is to identify pre-service science teacher perception about high order thinking skills (HOTs) in 21<sup>st</sup> century. This study employed quantitative design using a survey research method involved 120 pre-service science teachers from Tanjungpura University. The results of this study indicated that prospective science teachers have an awareness of the importance of HOTs and their also knowing that the learning do emphasized on the aspects of HOTs is essential to face the challenges of the 21<sup>st</sup> century. It is indicated by the mean score of pre-service science teacher perception about the important of HOTs to meet the challenges in the 21<sup>st</sup> century (M = 4.29, SD = 0.61) and the skills of HOT that their will be required to becomes a teacher in the 21<sup>st</sup> century (M = 4.31; SD = 0.47) in the high level. This result provides the reasons why we need cultivating a positive awareness of the importance of HOTs in order to fostering the need for teaching that emphasizes the aspects of HOTs during pre-service education.
The Effect of Residual Stress on Coupling Power Loss of VCSEL Modulus
Authors: Kuang Jao-Hwa , Hsu Chao-Ming , Lin Ah-Der , Luo Jyun-Wei 
Published: May 2018

Abstract
In this article, the effect of residual stress on active region misalignment of laser light sources for vertical cavity surface emitting laser (VCSEL) modulus has been studied. The post-weld-shift variation of active region introduced from the residual stress distribution variation for different VCSEL solder joints, i.e. tin-silver (Sn/3.5Ag) and tin-lead (Sn/37Pb) solder joints, are simulated by employing the thermal-elastic-plastic finite element model of MARC package. The ball grid solidification in reflow process and the creep deformation in the acceleration aging were simulated and analyze. The time and temperature dependent material properties of solders are employed. Numerical results indicate that the post-weld-shift introduced from residual stress in the solidification process are significant, and are also the key reasons to reduce the coupling efficiency in VCSEL packaging. The non-sequential components models in commercial Zemax optical package were used to estimate the optical coupling power loss between the active region and the fiber tip in VSCEL modulus. The results show that the proposed post-weld-shift model is feasible to analyze and to improve the solder joint design in the VCSEL packaging.