bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cross‐Cultural Comparison of ICD‐11 Complex Posttraumatic Stress Disorder Symptom Networks in Austria, the United Kingdom, and Lithuania
Authors: Knefel Matthias , Lueger‐Schuster Brigitte , Bisson Jonathan , Karatzias Thanos , Kazlauskas Evaldas , Roberts Neil P. 
Published: January 2019

AbstractThe 11th revision of the World Health Organization's International Classification of Diseases (ICD‐11) includes a new disorder, complex posttraumatic stress disorder (CPTSD). The network approach to psychopathology enables investigation of the structure of disorders at the symptom level, which allows for analysis of direct symptom interactions. The network structure of ICD‐11 CPTSD has not yet been studied, and it remains unclear whether similar networks replicate across different samples. We investigated the network models of four different trauma samples that included a total of 879 participants (M age = 47.17 years, SD = 11.92; 59.04% women) drawn from Austria, Lithuania, and Scotland and Wales in the United Kingdom. The International Trauma Questionnaire was used to assess symptoms of ICD‐11 CPTSD in all samples. The prevalence of PTSD and CPTSD ranged from 23.7% to 37.3% and from 9.3% to 53.1%, respectively. Regularized partial correlation networks were estimated and the resulting networks compared. Despite several differences in the symptom presentation and cultural background, the networks across the four samples were considerably similar, with high correlations between symptom profiles (ρs = .48–.87), network structures (ρs = .69–.75), and centrality estimates (ρs = .59–.82). These results support the replicability of CPTSD network models across different samples and provide further evidence about the robust structure of CPTSD. The most central symptom in all four sample‐specific networks and the overall network was “feelings of worthlessness.” Implications of the network approach in research and practice are discussed.
Weakly coupled directional coupler with simultaneous wide bandwidth and high directivity
Authors: Hammad Akhtar M. , Ayaz Zakir M. , Cheema Hammad M. 
Published: January 2019

AbstractWeakly coupled directional couplers are known to have poor directivities and narrow bandwidths. In order to improve both parameters simultaneously, this article demonstrates for the first time, that combination of shunt reactive loading and external impedance matching, results in high directivity, and wideband performance. The proposed directional coupler, fabricated on a Rogers 6035HTC substrate, demonstrates directivity greater than 20 dB over a fractional bandwidth of 35%, which is the highest reported for microstrip based design having weak coupling factor of 30 dB.
Experimental study of a printed ultra‐wideband modified circular monopole antenna
Authors: Kundu Surajit 
Published: January 2019

AbstractA compact (35 × 30 × 0.8 mm3) co‐planar waveguide (CPW)‐fed circular monopole ultra‐wideband (UWB) antenna with improved impedance band is proposed in this article. A frequency band from 3.1 to more than 20 GHz is achieved by bending the upper edges of co‐planar ground plane. Antenna parameters are studied by simulation and then validated by experimental measurement. The proposed antenna provides monopole‐like radiation pattern with high radiation efficiency of more than 80% and flat gain variation between 2 and 5 dBi. The antenna also exhibits consistency in group delay variation and linearity in the transfer function response. A good agreement is found in between simulated and measured results of the proposed design. The proposed antenna performance is compared with previously reported similar antennas.
Dual‐band branch‐line coupler with shorted stepped‐impedance stubs arranged in a Π‐shaped topology
Authors: Seko Murilo Hiroaki , Correra Fatima Salete 
Published: January 2019

AbstractThis article presents a transmission‐line‐based 3‐dB dual‐band branch‐line coupler. The coupler is easily realizable for ratios between the upper and lower operating frequencies ranging from 1.270 to 2.628. This means that it can be designed for two operation frequencies that are closer to each other in comparison with existing simple circuit topologies based on transmission lines, when considering a compact design. The complete set of equations for all possible responses of this dual‐band 90° hybrid coupler is derived. To evaluate its practical feasibility, the proposed circuit is analyzed with respect to the characteristic impedances of its transmission lines. A step‐by‐step procedure is presented to help the circuit designer deal with the use of the equations and all their degrees of freedom. For experimental validation, a microstrip dual‐band branch‐line coupler has been designed for operation at 3.835 and 5.285 GHz. A good agreement is observed between simulated and measured results.
Loss of whole chromosome X predicts prognosis of neuroblastoma patients with numerical genomic profile
Authors: Parodi Stefano , Pistorio Angela , Erminio Giovanni , Ognibene Marzia , Morini Martina , Garaventa Alberto , Gigliotti Anna Rita , Haupt Riccardo , Frassoni Francesco , Pezzolo Annalisa 
Published: January 2019

AbstractBackgroundNeuroblastoma (NB), a pediatric tumor of the sympathetic nervous system, is characterized by very frequent chromosomal aberrations at the onset of the disease. Identification of further risk factors for relapse, which could lead to increased survival and potentially reduced late effects among survivors, is still urgently needed. Segmental chromosome aberrations (SCA) are associated with poor prognosis, whereas numerical whole‐chromosome aberrations (NCA) are found in patients with a good prognosis; however, a small percentage of the latter patients (10%–15%) subsequently relapse and/or die of disease.ProcedureDNA copy‐number data from 174 NB patients with an NCA genomic profile were analyzed. Association between NCA and event‐free survival (EFS) was investigated by the Kaplan–Meier estimator and prognostic decision tree (DT).ResultsDT identified 65 patients with normal chromosome X and an excellent five‐year EFS (100%) independently from the stage at diagnosis. The association between poor EFS and whole chromosome X alterations was confirmed after stratification into two groups of different expected prognosis and by internal validation via bootstrap analysis. Furthermore, the association was also observed in an independent cohort of NB patients extracted from the data set of the National Cancer Institute TARGET Project for Neuroblastoma, but sample size was small (n = 75) and statistical significance was not achieved.ConclusionsLoss of whole chromosome X may represent a new prognostic marker for NB patients with an NCA genomic profile. If confirmed by further studies, this finding could indicate that such patients should be reclassified as intermediate risk and treated accordingly.
How Far Can You Measure?
Authors: Zinssmeister Andreas 
Published: January 2019

AbstractIf you recently bought a thermal camera, you might be wondering how far you can measure with it. Or maybe you're interested in purchasing one, but you aren't sure which one will both accurately measure your target and fit within your budget. The answer to “how far can you measure?” depends on factors such as resolution, instantaneous field of view (IFOV), lenses, the size of the object, and more.
Material Analysis in Fast Industrial Processes by LIBS
Authors: Jochum Tobias , Günther Jens‐Uwe , Bohling Christian 
Published: January 2019

AbstractLaser‐induced breakdown spectroscopy (LIBS) is recognized as a versatile technique for material analysis; especially in applications in which speed of analysis, sensitivity, and need for minimal or no sample preparation are key issues. These features make LIBS attractive for inline process monitoring, e.g. for material screening and sorting as well as for quality control purposes. However, the transfer of LIBS technology from the lab into high‐speed industrial environments entails technical and analytical challenges which we address in this article.
Accuracy of Two Ultrasound‐Guided Coracohumeral Ligament Injection Approaches: A Cadaveric Study
Authors: Majdalani Carl , Boudier‐Revéret Mathieu , Pape John , Brismée Jean‐Michel , Michaud Johan , Luong Dien Hung , Grabs Detlev , Chang Ke‐Vin , Chen Wen‐Shiang , Wu Chueh Hung , Sobczak Stéphane 
Published: January 2019

BackgroundGlenohumeral idiopathic adhesive capsulitis is a common shoulder condition that hinders functionality. Addressing the pathology has been extensively researched. Ultrasound (US)‐guided injections have shown their efficacy. However, no study has been conducted to compare anatomical accuracy between different approaches in targeting the coracohumeral ligament (CHL).ObjectiveTo investigate whether US‐guided injection of the CHL can be performed accurately using either the rotator interval (RI) or the coracoidal (CO) approach.MethodsAn experimental cadaveric case series.SettingAnatomy laboratory.SpecimensBoth shoulders of 13 Thiel‐embalmed cadavers.InterventionsThree physiatrists each injected a 0.1 mL bolus of colored dye in both shoulders of each cadaver using either the RI or the CO approach under US guidance. Each cadaver received a total of six injections (three injections per shoulder). The accuracy of the injection was determined following shoulder dissection by an anatomist.Main Outcome MeasureThe accuracy of the US‐guided injection of the CHL.ResultsThe RI approach yielded 36 accurate injections, giving it an accuracy of 100%. With the CO approach two injections were deemed inaccurate yielding an accuracy of 94%. There was no significant difference in accuracy between all operators.ConclusionsUS‐guided injection of the CHL can be performed accurately with both the RI and CO approaches. The RI approach was likely to be more accurate.
Display of Potassium Channel–Blocking Tertiapin‐Q Peptides on Gold Nanoparticles Enhances Depolarization of Cellular Membrane Potential
Authors: Muroski Megan E. , Oh Eunkeu , Deschamps JeffreyR. , Delehanty James B. 
Published: January 2019

AbstractThe use of nanoparticle (NP) systems to control cellular physiology, including membrane potential, can facilitate furthered understanding of many disparate cellular processes ranging from cellular proliferation to tissue regeneration. A gold NP (AuNP) bioconjugate system based on the honeybee venom peptide, tertiapin‐Q (AuNP‐TPN‐Q), that depolarizes membrane potential by targeting inward rectifier potassium channels (Kir), is developed. The conjugate elicits, in a peptide concentration–dependent manner, a greater and more rapid depolarization response compared to the free peptide alone. The specificity of the interaction of the AuNP‐TPN‐Q conjugate with the Kir channel using immunocytochemistry and competition binding assays is confirmed. It is further shown that membrane depolarization is photothermally reversible via the laser‐induced plasmonic heating of the AuNP, providing a level of control over Kir channels not afforded by currently available drugs. The functional nanobioconjugate described herein provides a new research tool for understanding the intricacies of ion channel activity and the modulation of cellular membrane potential.
pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study
Authors: Stéphanou Angélique , Ballesta Annabelle 
Published: January 2019

AbstractDespite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed. A systems pharmacology approach was undertaken to investigate TMZ pharmacokinetics‐pharmacodynamics (PK‐PD) incorporating the effect of local pH, tumor spatial configuration and micro‐environment. A hybrid mathematical framework was designed coupling ordinary differential equations describing the intracellular reactions, with a spatial cellular automaton to individualize the cells. A differential drug impact on tumor and healthy cells at constant extracellular pH was computationally demonstrated as TMZ‐induced DNA damage was larger in tumor cells as compared to normal cells due to less acidic intracellular pH in cancer cells. Optimality of TMZ efficacy defined as maximum difference between damage in tumor and healthy cells was reached for extracellular pH between 6.8 and 7.5. Next, TMZ PK‐PD in a solid tumor was demonstrated to highly depend on its spatial configuration as spread cancer cells or fragmented tumors presented higher TMZ‐induced damage as compared to compact tumor spheroid. Simulations highlighted that smaller tumors were less acidic than bigger ones allowing for faster TMZ activation and their closer distance to blood capillaries allowed for better drug penetration. For model parameters corresponding to U87 glioma cells, inter‐cell variability in TMZ uptake play no role regarding the mean drug‐induced damage in the whole cell population whereas this quantity was increased by inter‐cell variability in TMZ efflux which was thus a disadvantage in terms of drug resistance. Overall, this study revealed pH as a new potential target to significantly improve TMZ antitumor efficacy.
Impact of high‐resolution ocean–atmosphere coupling on fog formation over the North Sea
Authors: Fallmann Joachim , Lewis Huw , Sanchez Juan Castillo , Lock Adrian 
Published: January 2019

Sea‐surface temperature (SST) is a key driver for various interactions and feedbacks between components of the Earth System and can control local weather and climate. The formation of marine fog, for example, can be sensitive to small changes in SST at a scale of a few kilometres. As a contribution to understanding processes at the interface between air and sea, this article discusses results from a state‐of‐the‐art fully coupled regional atmosphere–land–ocean–wave prediction system for the UK at km scale. This study focuses on the impact of the changes in surface forcing resulting from coupling SST in the marine boundary layer and formation of summertime coastal fog over the North Sea.A study from July 2013 provided a good case to evaluate the role of SST in fog evolution. The benefit of an evolving SST in the coupled simulation is shown in capturing a warming trend in observed SST over the five‐day case study period, with a root‐mean‐square error (RMSE) against in situ observations of 1.1 K. In contrast, in uncoupled atmosphere‐only simulations, the initial‐condition SST is persisted for the duration of the case, as is more typical in current operational numerical weather prediction (NWP). In the uncoupled simulations, a cold bias develops over the modelling period and the RMSE against observed SST is 2.4 K.The impact of coupling is shown to propagate into the overlying marine boundary layer and therefore affect the formation of coastal fog. Increased heat flux from a relatively warmer sea surface in the coupled simulations led to near‐surface atmospheric instability, hampering stratus lowering and destroying the fog‐promoting inversion layer. This significantly reduced fog fractions in selected regions. The value of model coupling was assessed by comparing coupled and uncoupled simulations initialized at different times ahead of fog development.
Experimental and Ab Initio Study on the Intensitiesof f–f Transitions for the Molecular Eu(III)‐DOTP System
Authors: Janicki Rafał , Kędziorski Andrzej , Mondry Anna 
Published: January 2019

AbstractThe experimental f‐f transition intensities, derived from UV‐vis absorption and emission spectra of Eu(III)‐DOTP systems (where DOTP is 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetrayl)tetrakis‐(methylene))‐tetraphosphonate anion) in [C(NH2)3]5[Eu(DOTP)]⋅12.5H2O and K5[Eu(DOTP)]⋅11H2O crystals and in solution, were analyzed in terms of Judd‐Ofelt theory. A non standard approach was used to calculate Ωλ parameters by including both the absorption 7F0→2S+1LJ and emission 5D0→7FJ bands in the calculation procedure. The f‐f transition intensities of two {K4[Eu(DOTP)]}– clusters representing the two different forms of Eu(III)‐DOTP complex in K5[Eu(DOTP)]⋅11H2O crystal, calculated within ab initio approach were compared with the experimental counterparts. The theoretical results provided a deeper insight into the nature of the hypersensitive and highly‐forbidden f‐f transitions for system under study. The possible improvements of the theoretical approach are discussed in the light of the known mechanisms contributing to the intensities of f‐f transitions. Finally the solution structure of the [Eu(DOTP)]5– complex was examined by complementary techniques including temperature dependent UV‐vis absorption and time‐resolved emission spectroscopy. This enabled us to show that the structure of the [Eu(DOTP)]5– complex in solution is practically the same as those in crystals. In particular it means that there are no water molecules coordinated to the central Eu(III) cation. The observed decrease of luminescence integral intensities of the 5D0→7FJ bands at elevated temperatures of solution, usually assigned to a chemical reaction, is brought about actually by the changes of solution viscosity.
Pt(II)‐Based Artificial Nitroreductase: An Efficient and Highly Stable Nanozyme
Authors: Aghahosseini Hamideh , Tabatabaei Rezaei Seyed Jamal , Maleki Mahshid , Abdolahnjadian Davod , Ramazani Ali , Shahroosvand Hashem 
Published: January 2019

AbstractThe nitroreductases are a family of natural enzymes with great importance. Inspired the integration of biology and nanotechnology, herein, a rational design for the preparation of the platinum(II)‐based artificial nitroreductase is reported. Engineering the individual ligand scaffold, which on the one hand could form a highly stable complex with the platinum(II) as the catalytic active site and on the other hand could provide halogen bonding site for induce catalysis by approximation, creates an efficient and long‐term resistance artificial nitroreductase. The platinum(II)‐based artificial nitroreductase was characterized by FTIR, TEM, XRD, EDAX and ICP techniques. The reaction conditions were fully optimized for the reduction of high concentration p‐nitrophenol as a specific substrate in aqueous solution employing experimental design, which highlights the potential application of the designed artificial nitroreductase in wastewater treatment. Moreover, the enzyme‐like Michaelis‐Menten kinetics of the reaction was investigated. The prepared platinum(II)‐based artificial nitroreductase could be stable even after 20 catalytic cycles with excellent activity and it was represented a good turnover frequency.
Fuzzy Logic with Expert Judgment to Implement an Adaptive Risk-Based Access Control Model for IoT
Authors: Atlam Hany F. , Walters Robert J. , Wills Gary B. , Daniel Joshua 
Published: January 2019

AbstractThe Internet of Things (IoT) is becoming the future of the Internet with a large number of connected devices that are predicted to reach about 50 billion by 2020. With proliferation of IoT devices and need to increase information sharing in IoT applications, risk-based access control model has become the best candidate for both academic and commercial organizations to address access control issues. This model carries out a security risk analysis on the access request by using IoT contextual information to provide access decisions dynamically. This model solves challenges related to flexibility and scalability of the IoT system. Therefore, we propose an adaptive risk-based access control model for the IoT. This model uses real-time contextual information associated with the requesting user to calculate the security risk regarding each access request. It uses user attributes while making the access request, action severity, resource sensitivity and user risk history as inputs to analyze and calculate the risk value to determine the access decision. To detect abnormal and malicious actions, smart contracts are used to track and monitor user activities during the access session to detect and prevent potential security violations. In addition, as the risk estimation process is the essential stage to build a risk-based model, this paper provides a discussion of common risk estimation methods and then proposes the fuzzy inference system with expert judgment as to be the optimal approach to handle risk estimation process of the proposed risk-based model in the IoT system.
Reduced Opioid Use after Surgeon-Administered Genicular Nerve Block for Anterior Cruciate Ligament Reconstruction in Adults and Adolescents
Authors: Caldwell George L. , Selepec Michael A. 
Published: January 2019

Background Pain management after anterior cruciate ligament reconstruction (ACLR) may pose a risk of prolonged opioid use. Questions/Purposes The purposes of this study in ACLR were to investigate the efficacy of a surgeon-administered local–regional block of specific genicular nerves on post-operative analgesia following ACLR and to quantify the outpatient opioid consumption and duration through the complete post-operative course. Methods Prospectively, all patients undergoing primary ACLR by a single surgeon were studied over a 10-month period. Exclusion criteria consisted of history of pre-operative opioid use, revision surgery, multi-ligament surgery, allergy to oral opioids, and allergy to local anesthetic. ACLR was performed using autograft or allograft patellar tendon bone (PTB) graft under general anesthesia. At the conclusion of the procedure, all patients received a local anesthetic (bupivacaine 0.25%) injection by the surgeon including a unique circumferential genicular nerve and fat pad block performed based on anatomic landmarks without use of image guidance. Post-operatively, the quantity and duration of opioid use (hydrocodone 5 mg) and pain scores were recorded for 4 months prospectively. Statistical analysis was performed to evaluate risk factors for increased opioid use. Results A single surgeon performed 75 ACLRs. After exclusions, a total of 70 patients were enrolled and followed prospectively. None were lost to follow-up. Total opioid consumption ranged from 0 to 30 tablets. The average number of opioid tablets used over the 4-month post-operative course was 5.5 (± 6.7). After surgery, 84% of patients took between 0 and 10 tablets and 21% of patients took no opioids throughout their entire post-operative course. The average duration of consumption was 2.6 days (± 3.1). No patients were taking opioids at the 6-week or 4-month follow-up. There were no refills required. No statistically significant differences were seen in regard to graft choice of autograft PTB ( n = 48) vs allograft PTB ( n = 22) in total opioid consumption or duration of use. In comparing adolescent ( n = 31) versus adult ( n = 39), no significant difference was seen in total opioid consumption or duration of use. All patients were satisfied with the post-operative pain management protocol. Conclusion Opioid use was unexpectedly low among patients undergoing ACLR after a surgeon-administered circumferential genicular nerve block and fat pad infiltration. With this protocol, the graft choice and patient age did not correlate with increased opioid use. These results could be useful in guiding post-operative opioid prescribing after ACLR.
Progressive research collaborations and the limits of soft power
Authors: Kits Olga , Angus Camille , MacLeod Anna , Tummons Jonathan 
Published: January 2019

Collaboration in diverse teams is a central topic area in medical education, health research, and healthcare. As medical education researchers we implemented an internal grant policy to develop a progressive research partnership based on widely accepted guidelines for responsible conduct of research. Our intention was to proactively manage and guide group expectations around issues such as access to data and authorship. Our policy was based on ‘soft power’ principles, using the persuasiveness of ideas, relationships and inducements to encourage people to ‘want what you want.’ This article shares how we developed and implemented the policy, experienced first-hand the limits of soft power, and it explicates some of the lessons learned.