bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of a new evaporative misting system based on photovoltaic/thermal and ventilation heat exchange in sow farms: a case study in Guangzhou, China
Authors: Xie Yue , Li Qinghua , Ma Hongqiang , Wang Jiajun , Wang Shengxun 
Published: November 2024

AbstractIn order to improve the regional applicability of existing evaporative misting systems, a new evaporative misting system based on photovoltaic/thermal and ventilation heat exchange is proposed for sow farms. Compared to traditional systems, the proposed system can help to improve their regional applicability and reduce their energy consumption. Meanwhile, its simulation model is constructed and the reliability is verified for its core equipment. The maximum error is less than 14.5% for the above models. Through simulation, the optimal regulation variable ranges in the proposed system are determined for mass flow rate of working fluid (MFWF) and misting power by analysing its operating characteristics. The results show that its optimal ranges of MFWF and misting power are 7245–9245 kg/h and 40–45 kW, respectively. The annual performance is further quantified and analysed under different load ratios for the proposed system in Guangzhou. It can be found that the annual exergy loss, heat exchange coefficient and solar energy benefits of the proposed system in Guangzhou are negatively correlated with load ratio, but its annual energy consumption and energy efficiency ratio are positively correlated. Meanwhile, the system performance and benefits are not significantly improved by increasing device investment and sow density when load ratio exceeds 120% in sow farms. The above conclusion can contribute to improving the existing evaporative misting systems in sow farms and guiding the operating regulation of the proposed system.
Taxonomic summary of Schyzocotyle (Cestoda: Bothriocephalidae) with a redescription of Schyzocotyle nayarensis (Malhotra, 1983) from India
Authors: Marick J. , Choudhury A. , Scholz T. , Biswas R. , Ash A. 
Published: November 2024

Abstract
In this study, we use an integrative taxonomic approach to redescribe Schyzocotyle nayarensis (Malhotra, 1983) (Cestoda: Bothriocephalidae), based on newly collected specimens from the type-host Raiamas bola (Hamilton, 1822) (Cypriniformes: Danionidae) in Fulbari, Siliguri, West Bengal, India. The detailed morphological assessment, from whole mounts, histology and scanning electron microscopy, offers additional insights into the scolex structure, vitelline follicles, and egg morphology. Molecular data from this and previous studies corroborate the identity and systematics of S. nayarensis as a bothriocephalid closely related to the Asian Fish Tapeworm, Schyzocotyle acheilognathi (Yamaguti, 1934). This study elucidates the historical context and taxonomic ambiguities surrounding S. nayarensis, emphasizing the key role of the scolex in both generic and species identification. Amendments to the diagnosis of Schyzocotyle Akhmerov, 1960 are proposed. A differential diagnosis of the two valid species within the genus, namely S. acheilognathi and S. nayarensis, is also provided. An evaluation of the taxonomic status of Bothriocephalus teleostei Malhotra, 1984, and Capooria barilii Malhotra, 1985 suggests that they may be S. nayarensis. Finally, we posit that none of the ten species of Ptychobothrium Lönnberg, 1889 described from Indian freshwater teleosts belong to this genus but instead appear to be a mix of species belonging to Schyzocotyle, Senga Dollfus, 1934, and possibly even Proteocephalidae La Rue, 1911; all require further study based on newly collected, properly fixed specimens and an integrated taxonomic approach. Finally, future survey studies may reveal hidden diversity of Schyzocotyle species in Indian cyprinoids.
Exploring South Africa's hidden marine parasite diversity: two new marine Ergasilus species (Copepoda: Cyclopoida: Ergasilidae) from the Evileye blaasop, Amblyrhynchote honckenii (Bloch)
Authors: van der Spuy Linda , Narciso Rodrigo B. , Hadfield Kerry A. , Wepener Victor , Smit Nico J. 
Published: November 2024

Abstract
Marine parasites remain understudied in South Africa with little information available on their diversity and the effects these parasites may have on their hosts. This is especially true for parasitic copepods within the family Ergasilidae. Among the 4 genera known in Africa, Ergasilus Nordmann, 1832 is the most speciose with 19 reported species. However, this represents only 12% (19/163) of the global diversity. Furthermore, only 5 known African species are reported from marine environments, and only 1 is reported from the South African coastline. Given the rich biodiversity along this coastline, a high marine parasite diversity could be expected from these shores. As a case study, the Evileye blaasop, Amblyrhynchote honckenii (Bloch), a marine and brackish fish species, was screened for parasites along the South African coastline. This resulted in the discovery of 2 species of Ergasilus new to science (Ergasilus arenalbus n. sp. and Ergasilus chintensis n. sp.), which makes them the second and third ergasilid species reported for tetraodontid pufferfishes worldwide. Although genetically distinct, the 2 newly described species clustered in the same subclade within the Ergasilidae based on 18S rDNA, 28S rDNA and COI mtDNA phylogenies. The newly described species differ morphologically from each other, and their respective congeners based on the size and armature of the antenna; body segmentation; and general ornamentation throughout the entire body. The addition of these 2 new species from a single host species indicates that South Africa's marine fishes contain most probably a hidden parasitic copepod diversity that is worth exploring.
Impact of omega-3 fatty acid supplementation on clinical manifestations in autism spectrum disorders: an umbrella review of meta-analyses
Authors: Abbasi Hamid , Parhiz Abdolrahman , Khoshdooz Sara , Bakhshimoghaddam Farnush , Doaei Saeid , Gholamalizadeh Maryam 
Published: November 2024

Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental condition. Omega-3 fatty acid insufficiency has been linked to ASD. This umbrella meta-analysis was performed to investigate the effects of omega-3 supplementation on clinical manifestations in participants with ASD. Based on the PRISMA statement, databases including Web of Science, PubMed and Scopus were systematically searched for published meta-analyses on the effect of omega-3 supplementation on ASD up to December 2023. To assess the risk of bias, the assessment of multiple systematic reviews (AMSTAR)-2 was utilised. The outcomes were core and non-core symptoms of ASD including social withdrawal/lethargy, cluttering speech, hyperactivity, irritability and stereotypy. Seven meta-analyses eventually remained in the umbrella review. The results revealed that omega-3 fatty acid supplementation caused a significant reduction in cluttering speech in studies conducted on age ≤8 years (effect size (ES) −0·30; 95% confidence interval (CI) −0·55, −0·06; P = 0·02). Omega-3 supplementation caused a significant reduction in hyperactivity in participants ≤8 years (ES −0·30; 95% CI −0·55, −0·06; P = 0·02) and in participants who received the supplements for more than 14 weeks (ES −0·30; 95% CI −0·55, −0·06; P = 0·02). A dosage of ≤1000 mg/d of omega-3 supplementation led to a significant increase in the stereotypy/restricted and repetitive interests and behaviours (ES 0·19; 95% CI 0·03, 0·35; P = 0·02). This umbrella review revealed that omega-3 fatty acid may be a beneficial supplement to control cluttering speech and hyperactivity in children with ASD who are 8 years old or younger.
Navigating healthcare during a pandemic: what parents of CHD children want healthcare professionals to know
Authors: Harvey Kayla A. , Holt Tracy D. 
Published: November 2024

AbstractBackground:The COVID pandemic has had deleterious effects on the mental health of the global population. Parents of children with CHD were particularly vulnerable to negative mental health outcomes such as depression, anxiety, and perceived stress. A better understanding of the CHD parent experiences, needs, and concerns while navigating the healthcare system during a pandemic is needed.Methods:Online survey responses from 71 parents of young children with CHD representing families across the United States of America and Canada were analysed. Qualitative data were collected one year into the COVID pandemic. Thematic analysis was used to examine responses to the open-ended question “What would you like healthcare professionals (doctors, nurses) to know about your experience of being a parent with a child with CHD during the COVID-19 pandemic?.”Results:Two major themes with subthemes and an umbrella theme emerged from the parents’ responses (1) Pandemic Parenting: The Emotional Toll of Hospital Visitation Restrictions, Dealing with Social Distancing, Feeling Isolated, Decision Making in Uncertainty, and Playing it Safe versus Returning to Normal and (2) Unmet Expectations of Care: Needing Information, Wanting Empathy, Requesting Respect, Questioning Care Quality, and the umbrella theme of: Our Lives were Turned Upside Down.Conclusion:CHD parents describe a negative impact of healthcare-related challenges during the COVID pandemic. These findings may offer insight to how healthcare professionals can better support the mental health and care burden of CHD parents during future pandemics.
To prevent sudden death in m.3243A>G carriers, comprehensive neurologic, cardiac, and pulmological examinations are required
Authors: Mehri Sounira , Finsterer Josef 
Published: November 2024

AbstractThe interesting study has limitations that put the results and their interpretation into perspective. m.3243A>G carriers should undergo prospective testing for multisystem disease to avoid missing subclinical multisystem involvement. m.3243A>G carriers with hypertrophic cardiomyopathy require long-term electrocardiogram recordings to determine whether implantable cardioverter defibrillator implantation is necessary or not. To assess the outcome of m.3243A>G carriers, knowledge of heteroplasmy rates and mtDNA copy numbers is required. It is tempting to assign pathogenicity when any pathogenic variant is seen with genotype-phenotype correlation. However, double hits are possible and if genetic information is to be used to screen or risk-stratify other family members, the standard of care would be to ensure that post-mortem genetic autopsy is performed for a panel of causative genes, and that an autopsy is done to exclude other causes of death, if possible.
Cyber risk within capital models
Authors: Grewal Jasvir , Cartagena Simon 
Published: November 2024

Abstract
The (re)insurance industry is maturing in its ability to measure and quantify Cyber Risk. The risk and threat landscapes around cyber continue to evolve, in some cases rapidly. The threat actor environment can change, as well as the exposure base, depending on a variety of external factors such as political, economic and technological factors. The rapidly changing environment poses interesting challenges for the risk and capital actuaries across the market. The ability to accurately reflect all sources of material losses from cyber events is challenging for capital models and the validation exercise. Furthermore, having a robust enterprise risk management (ERM) framework supporting the business to evaluate Cyber Risk is an important consideration to give the board comfort that Cyber Risk is being effectively understood and managed by the business. This paper discusses Cyber Risk in relation to important risk and capital model topics that actuaries should be considering. It is challenging for the capital models to model this rapidly changing risk in a proportionate way that can be communicated to stakeholders. As model vendors continue to mature and update models, the validation of these models and the ultimate cyber capital allocation is even more complex. One’s view of risk could change rapidly from year to year, depending on the threat or exposure landscape as demonstrated by the ransomware trends in recent years. This paper has been prepared primarily with General Insurers in mind. However, the broader aspects of capital modelling, dependencies and ERM framework are relevant to all disciplines of the profession.
Handling cyberspace's state of intermediacy through existing international law
Authors: Giovannelli Davide 
Published: November 2024

Abstract
How international law applies to the use of information and communications technology by States is still a matter of discussion. Against this background, cyberspace has become the main area of competition between States, and this competition, to put it simply, is resulting in a constant low-intensity warfare below the threshold for a use of force. Such low-intensity cyber warfare, from a legal point of view, revitalizes the debate over the concept of a “state of intermediacy” that has the potential to overcome the dichotomy between peace and war. In the present author's opinion, this state of intermediacy also supports the idea that the international humanitarian law (IHL) principle of distinction should be applied, even before the eruption of a full-scale war, whenever wartime means and capabilities are employed by States. This paper argues that some opacities in international law have created favourable conditions for such constant low-intensity warfare, and that tackling the identified opacities would therefore be beneficial in order to achieve a more peaceful cyberspace. Thus, the paper goes on to address one of the identified opacities, namely the definition of espionage under international law, because, as international law now stands, it does not allow us to tackle the other identified opacities. Finally, the paper discusses how the proposed narrow interpretation of espionage can cope with the IHL principle of distinction in the cyber domain.
Characterizing the Impacts of 2024 Total Solar Eclipse Using New York State Mesonet Data
Authors: Wang Junhong , Dai Aiguo , Yu Chau‐Lam , Shrestha Bhupal , McGuinnes D. J. , Bain Nathan 
Published: November 2024

AbstractOn 8 April 2024, a rare total solar eclipse (TSE) passed over western New York State (NYS), the first since 1925 and the last one until 2079. The NYS Mesonet (NYSM) consisting of 126 weather stations with 55 on the totality path provides unprecedented surface, profile, and flux data and camera images during the TSE. Here we use NYSM observations to characterize the TSE's impacts at the surface, in the planetary boundary layer (PBL), and on surface fluxes and CO2 concentrations. The TSE‐induced peak surface cooling occurs 17 min after the totality and is 2.8°C on average with a maximum of 6.8°C. It results in night‐like surface inversion, calm winds, and reduced vertical motion and mixing, leading to the shallowing of the PBL and its moistening. Surface sensible, latent and ground heat fluxes all decrease whereas near‐surface CO2 concentration rises as photosynthesis slows down.
Combination strategies with PARP inhibitors in BRCA-mutated triple-negative breast cancer: overcoming resistance mechanisms
Authors: Jain Aditi , Barge Alan , Parris Christopher N. 
Published: November 2024

Abstract
Triple-negative breast cancer (TNBC) is a particularly aggressive breast cancer subtype, characterised by a higher incidence in younger women, rapid metastasis, and a generally poor prognosis. Patients with TNBC and BRCA mutations face additional therapeutic challenges due to the cancer’s intrinsic resistance to conventional therapies. Poly (ADP-ribose) polymerase inhibitors (PARPis) have emerged as a promising targeted treatment for BRCA-mutated TNBC, exploiting vulnerabilities in the homologous recombination repair (HRR) pathway. However, despite initial success, the efficacy of PARPis is often compromised by the development of resistance mechanisms, including HRR restoration, stabilisation of replication forks, reduced PARP1 trapping, and drug efflux. This review explores latest breakthroughs in overcoming PARPi resistance through combination therapies. These strategies include the integration of PARPis with chemotherapy, immunotherapy, antibody-drug conjugates, and PI3K/AKT pathway inhibitors. These combinations aim to enhance the therapeutic efficacy of PARPis by targeting multiple cancer progression pathways. The review also discusses the evolving role of PARPis within the broader treatment paradigm for BRCA-mutated TNBC, emphasising the need for ongoing research and clinical trials to optimise combination strategies. By tackling the challenges associated with PARPi resistance and exploring novel combination therapies, this review sheds light on the future possibilities for improving outcomes for patients with BRCA-mutated TNBC.
Development of a dynamic clinical assessment for finals
Authors: Mullan Francesca , Rolland Sarah , Desai Hannah , Stone Simon James , Bateman Heidi Louise 
Published: November 2024

AbstractDifferent dental schools assess ‘finals' in different ways. Assessment of applied clinical knowledge and skills are commonly based on either objective structured clinical examinations or multiple ‘long cases'. While iterative changes naturally occur throughout education and assessment, it is important to step back and question what skills should be assessed and either identify or develop new assessment methods. At the point of graduation, these should capture the professional attributes expected of a ‘qualified dentist'. New graduate attributes we consider valuable, which can often be challenging to assess summatively in a high-stakes examination, include effective communication skills in a variety of contexts, the ability to be reactive and responsive, and to manage case complexity appropriately for the graduate level.Here, we report a dynamic assessment incorporating candidate interaction with a range of stakeholders. To reflect progression of changing clinical situations, we move away from solely traditional case-based discussions, which principally assess interaction with an examiner, and have introduced multiple scenarios with rapid situation changes, long-term follow-up, treatment complications and challenging communications. A cross-cutting assessment rubric was developed to assess candidates' information gathering/giving, communication, clinical and diagnostic reasoning, applied knowledge, management and professionalism.
Understanding demographic events and migration patterns in two urban slums of Nairobi City in Kenya
Authors: Omondi Evans , Iddi Samuel , Chepkemoi Sharon , Mugotitsa Bylhah , Cygu Steve , Okumu Boscow , Ziraba Abdhalah , Kadengye Damazo T. , Kiragga Agnes 
Published: November 2024

AbstractUnderstanding the dynamics of movements between different demographic events is essential for informing effective population management strategies. This study aims to characterize the trajectories of demographic and other vital events within the Nairobi Urban Health and Demographic Surveillance System (NUHDSS). Thus, it intends to unravel patterns and trends that can guide the development of targeted policies and interventions to address the population’s evolving needs. Using a continuous-time homogeneous multi-state Markov model, longitudinal data from 223,350 individuals in Korogocho and Viwandani urban slums, we study the enumeration, births, deaths, and migrations among urban poor in Nairobi, shedding light on population dynamics and movements over time, disaggregated by gender. Findings indicate a positive net migration in population per thousand in 2002, dropping in 2004, with Viwandani consistently showing higher birth rates than Korogocho. Males generally have higher death rates than females. Females from Viwandani are 39.0% more likely to exit after enumeration compared to Korogocho, while males are 35.6% more likely to move from enumeration to exit compared to males from Korogocho. Both genders from Viwandani have a decreased likelihood of moving from birth to death compared to Korogocho. Our findings provide unique insights into migration in urban Kenya, the frequency and movement to different demographic events and any gender differences that warrant strategic policies for effective population and health planning in Africa. These findings can inform the design of effective health interventions that are often affected by migration and population growth.
Strategies for resolving challenging psychedelic experiences: insights from a mixed-methods study
Authors: Wood Maximillian J. , McAlpine Rosalind G. , Kamboj Sunjeev K. 
Published: November 2024

AbstractPsychedelic substances are garnering renewed interest for their potential therapeutic applications, yet the mechanisms by which challenging experiences during psychedelic use contribute to positive outcomes remains poorly understood. Here we present a mixed-methods investigation into the strategies individuals employ to navigate difficult psychedelic experiences and their relationship to emotional breakthrough. Qualitative analysis of accounts from psilocybin retreat participants (n = 16) informed the development of the Responses to Challenging Psychedelic Experiences Inventory (ReCiPE). In a subsequent online survey (n = 529), exploratory factor analysis of the ReCiPE revealed three primary response strategies: Acceptance and Reappraisal, Sensory Regulation and Physical Interaction, and Social Support and Disclosure. Exploratory correlation and multiple regression analyses demonstrated significant relationships between different types of challenges, response strategies and emotional breakthrough. Notably, Acceptance and Reappraisal, and Social Support and Disclosure strategies were positively associated with greater emotional breakthrough. Fear-related challenges were negatively associated with emotional breakthrough and involved fewer adaptive coping strategies. These findings elucidate the complex interplay between challenging experiences and adaptive responses in psychedelic contexts, offering insights for optimising therapeutic protocols and enhancing safety in both clinical and non-clinical settings.