bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Loss to Follow-up in 3202 Patients at 2 Years After Anterior Cruciate Ligament Reconstruction: Implications for Identifying Health Disparities in the MOON Prospective Cohort Study
Authors: Ramkumar Prem N. , Tariq Muhammad B. ,   MOON Knee Group, Amendola Annunziato , Andrish Jack T. , Brophy Robert H. , Dunn Warren R. , Flanigan David C. , Huston Laura J. , Jones Morgan H. , Kaeding Christopher C. , Kattan Michael W. , Marx Robert G. , Matava Matthew J. , McCarty Eric C. , Parker Richard D. , Vidal Armando F. , Wolcott Michelle L. , Wolf Brian R. , Wright Rick W. , Spindler Kurt P. 
Published: October 2019

Background: Understanding the risk factors for loss to follow-up in prospective clinical studies may allow for a targeted approach to minimizing follow-up bias and improving the generalizability of conclusions in anterior cruciate ligament reconstruction (ACLR) and other sports-related interventions. Purpose: To identify independent risk factors associated with failure to complete (ie, loss to follow-up) patient-reported outcome measures (PROMs) at 2 years after ACLR within a well-funded prospective longitudinal cohort. Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: All patients undergoing primary or revision ACLR enrolled in the prospectively collected database of the multicenter consortium between 2002 and 2008 were included. Multivariate regression analyses were conducted to determine which baseline risk factors were significantly associated with loss to follow-up at a minimum of 2 years after surgery. Predictors assessed for loss to follow-up were as follows: consortium site, sex, race, marital status, smoking status, phone number provided (home or cell), email address provided (primary or secondary), years of school completed, average hours worked per week, working status (full-time, part-time, homemaker, retired, student, or disabled), number of people living at home, and preoperative PROMs (Knee injury and Osteoarthritis Outcome Score, Marx Activity Rating Scale, and International Knee Documentation Committee). Results: A total of 3202 patients who underwent ACLR were enrolled. The 2-year PROM follow-up rate for this cohort was 88% (2821 of 3202). Multivariate analyses showed that patient sex (male: odds ratio [OR], 1.80) and race (black: OR, 3.64; other nonwhite: OR, 1.81) were independent predictors of 2-year loss to follow-up of PROMs. Education level was a nonconfounder. Conclusion: While education level did not predict loss to follow-up, patients who are male and nonwhite are at increased risk of loss to follow-up of PROM at 2 years. Capturing patient outcomes with minimal loss depends on equitable, not equal, opportunity to maximize generalizability and mitigate potential population-level health disparities. Registration: NCT00478894 (ClinicalTrials.gov identifier).
Acute urinary retention and progressive paraplegia with genital infection: A case report of transverse myelitis
Authors: Kim Eun , Lee Duk Hee 
Published: October 2019

Introduction:Transverse myelitis (TM) is a rare inflammatory disorder involving single or multiple spinal segments. There are various Infectious and parainfectious causes.Case presentation:We report the case of 29‐year‐old female who presented to an emergency department with acute urinary retention, progressive headache and sensory and motor deficits with a genital infection. Cerebrospinal fluid (CSF) analysis revealed WBC 75/μL, protein 96 (15‐40 mg/dL), and VZV IgG positive. The magnetic resonance image (MRI) of the spine revealed acute transverse myelitis of C4, C6/C7 and T2‐T3, T4‐T7. She was treated with steroid pulse therapy, intravenous antiviral therapy, antibiotics, and rehabilitation. Urinary symptoms resolved in six days and her motor deficit resolved. She had mild numbness in the thigh area 2 months later.Discussion:Identification of the causes and diagnosis of TM are challenging because there are variable clinical signs and numerous potential pathogens.Conclusion:It is essential to diagnosis TM in the early and timely phase, careful, detailed history and thorough physical examination by emergency physicians.
Treatment outcomes and efficacy of pars plana vitrectomy-hyaloidotomy-zonulectomy-iridotomy in malignant glaucoma
Authors: Raj Srishti , Thattaruthody Faisal , Joshi Gunjan , Seth Natasha Gautam , Kaushik Sushmita , Pandav Surinder Singh 
Published: October 2019

Aim: To study the treatment outcomes and efficacy of pars plana vitrectomy-hyaloidotomy-zonulectomy-iridotomy in malignant glaucoma. Method: A retrospective case series study of patients treated for malignant glaucoma between 2005 and 2017. The treatment included medical management as first-line in the form of cycloplegic with anti-glaucoma medications (AGM) or pars plana vitrectomy-hyaloidotomy-zonulectomy-iridotomy as second-line therapy. The resolution was defined as ‘deepening of central anterior chamber’ with intraocular pressure of ⩽ 21 mm Hg (minimum on two consecutive visits 1 week apart) with or without topical anti-glaucoma medications in the absence (complete success) or presence (qualified success) of systemic medications. Results: Twenty-three eyes of 22 patients were included. At the time of diagnosis of malignant glaucoma preceding surgeries were cataract surgery (13 eyes) and trabeculectomy (4 eyes). One eye each had phacotrabeculectomy, Yag capsulotomy and optical keratoplasty. Eighteen eyes were pseudophakic and two eyes were phakic. At presentation, mean intraocular pressure was 26.25 ± 14.78 mmHg which was decreased to 15.90 ± 8.12 mmHg (p < 0.0001) at final follow-up (median follow-up was 15.50 months). Fifteen (75%) eyes had complete success, 3 (15%) eyes had qualified success and 2 (10%) eyes had treatment failure. Of 15 eyes that had achieved complete success, 3 eyes had undergone medical management and 12 eyes undergone second-line procedure. There was no significant difference in visual acuity or number of anti-glaucoma medication at presentation and final follow-up (p > 0.05). Conclusions: Though malignant glaucoma is highly refractory to treatment, appropriate management in the form of medical or vitrectomy-hyaloidotomy-zonulectomy-iridotomy could achieve 90% success in this series.
Anterior versus posterior approach total hip arthroplasty: patient-reported and functional outcomes in the early postoperative period
Authors: Martusiewicz Alexander , Delagrammaticas Dimitri , Harold Ryan E , Bhatt Surabhi , Beal Matthew D , Manning David W 
Published: October 2019

Purpose: Direct anterior approach total hip arthroplasty (DA THA) has been reported to improve early outcomes compared to posterior approach THA up to 6 weeks postoperatively. Limited weekly outcomes data are available prior to 6 weeks. We evaluate outcomes including when patients first drive a car, leave home, and discontinue their assist device. Methods: Patients undergoing THA for primary osteoarthritis were prospectively enrolled. Outcomes data were collected preoperatively and postoperatively at weekly intervals for 6 weeks. Results: 111 patients (55 DA and 56 posterior approach) were enrolled. There was no significant difference ( p > 0.05) in pre-surgical Patient-Reported Outcomes Measurement Information System (PROMIS) scores or modified Harris Hip Score (mHHS). Postoperatively, the DA THA group had decreased length of stay ( p = 0.0002) and increased distance walked on postoperative day 1 and 2 ( p = 0.011, p = 0.0004). The DA group had lower pain scores ( p < 0.05) and required less day 1 and total narcotics ( p = 0.029, p = 0.01). The DA cohort had improved PROMIS Physical Function scores and mHHS up to 5 weeks postoperatively. DA patients discontinued their assistive device 8 days earlier ( p = 0.01), left home 3 days earlier ( p = 0.001), and drove a car 5 days earlier ( p = 0.01). Conclusions: Patients undergoing DA THA discontinued their assistive device, left their home, and drove a car sooner than posterior approach patients. We found improvement in physical function with DA, and it persisted up to 5 weeks postoperatively. Furthermore, DA patients had significantly shorter length of stay, improved mobilisation, decreased narcotic requirements and improved inpatient pain scores compared to posterior approach THA. Future randomised controlled study should be performed to minimise the biases inherent in this study methodology and confirm the results.
Multimodal Smoking Cessation in a Real-Life Setting: Combining Motivational Interviewing With Official Therapy and Reduced Risk Products
Authors: Caponnetto Pasquale , DiPiazza Jennifer , Cappello Giorgio Carlo , Demma Shirin , Maglia Marilena , Polosa Riccardo 
Published: October 2019

Background: Tobacco use is a global pandemic, affecting an estimated 1.2 billion people and resulting in substantial health burdens and associated costs. Objectives: The aim of this study was to estimate the efficacy of several treatments for smoking cessation in a real-life setting and to evaluate predictors of smoking abstinence. Methods: This research was designed with a sample of 593 cases recorded over the period between 2015 and 2016. Six treatment groups were included: (1) bupropion and motivational interviewing (MI); (2) bupropion, nicotine replacement therapy (NRT), and MI; (3) NRT and MI; (4) varenicline and MI; (5) personal vaporizer electronic cigarette and MI; and (6) electronic cigarette, cigarette like “cigalike,” and MI. Results: Results support the efficacy of all treatment groups when used in a real-life setting. The predictors of smoking abstinence were sex, partner smoking status, previous quit attempts, daily consumption, self-efficacy, and level of nicotine dependence. Conclusions: The use of different therapeutic strategies in clinical practice, including pharmacotherapy and nonstandard electronic nicotine delivery systems, such as an electronic cigarette, ensures a greater chance of cessation success and the possibility of tailoring interventions according to patients’ resources.
Primary small intestinal neuroendocrine tumors are highly prevalent and often multiple before metastatic disease develops
Authors: Eriksson J. , Norlén O. , Ögren M. , Garmo H. , Ihre-Lundgren C. , Hellman P. 
Published: October 2019

Background: Small intestinal neuroendocrine tumors are the most common of small bowel malignancies with a clinical incidence of about 1 per 100,000 persons per year. There has been a threefold increase in the incidence of small intestinal neuroendocrine tumor during later decades, but there are no studies that clarify whether this is due to a true higher incidence or if the rise is a mere product of, for instance, improved diagnostic modalities. The aim of this study was to investigate the incidence of clinical as well as subclinical small intestinal neuroendocrine tumors found at autopsy as well as describing the frequency of concomitant malignancies in patients with small intestinal neuroendocrine tumor. Materials and methods: An autopsy registry from the Malmö county population from 1970 to 1982 with an 87% autopsy rate was used. The clinical autopsy reports for patients coded for the existence of “carcinoid tumor” were scrutinized for the presence of small intestinal neuroendocrine tumor, metastatic disease, and concomitant malignancies. Details of patients with clinically diagnosed small intestinal neuroendocrine tumor during this time period were gathered from the Swedish Cancer Registry. Results: The mean annual incidence of small intestinal neuroendocrine tumor during this period was 5.33 per 100,000 individuals, and the mean annual prevalence was 581 per 100,000. The cause of death in the majority of cases was not due to small intestinal neuroendocrine tumor. In total, 48% of the people with small intestinal neuroendocrine tumor had at least one other malignancy, most commonly colorectal cancer. Conclusion: Most small intestinal neuroendocrine tumors are subclinical, and persons living with them will often die due to other causes. There was a high rate of multiple primary tumors (40%), suggesting that multiple tumors seem to arise before the advent of metastatic disease. Moreover, a comparably high rate of associated colorectal carcinoma was found.
Cerebrovascular complications in tuberculous meningitis—A magnetic resonance imaging study in 90 patients from a tertiary care hospital
Authors: Soni Neetu , Kumar Sunil , Shimle Anil , Ora Manish , Bathla Girish , Mishra Prabhakar 
Published: October 2019

Background Cerebrovascular complications of tuberculous meningitis (TBM) are associated with increased morbidity and mortality. We retrospectively reviewed clinicoradiological findings of 90 TBM patients who presented to a tertiary care hospital, with emphasis on frequency and distribution of infarcts on diffusion imaging and pattern of vascular involvement on magnetic resonance (MR) angiography (MRA). Materials and methods MR images of 90 TBM patients at presentation (2012–2018) were coanalyzed by two radiologists for tuberculomas, leptomeningeal enhancement (LM), hydrocephalus, infarct and vascular abnormalities. Infarcts were categorized based on location (“tubercular” (TB) or “ischemic” zones) and arterial supply (perforators and cortical branches). Clinical and laboratory findings were correlated with imaging data. Results Ninety TBM patients (age 10–82 years) were enlisted after application of inclusion criteria. Tuberculomas were most common (100%) followed by LM (84.4%), cerebral infarcts (57.7%) and hydrocephalus (29%). Location-wise, 35% infarcts were in ischemic, 13% in TB and 15% in both zones. According to arterial supply, infarcts equally (50%) involved perforators from the lateral lenticulostriate and posterior cerebral (PCA)/basilar artery (BA) followed by medial lenticulostriate arteries (23%). MRA was available in 74.4% and abnormal in 43.2%. The middle cerebral artery was frequently involved (76%) followed by the anterior cerebral artery (38%), internal carotid artery (31%), PCA and BA. Six had diffuse narrowing with a paucity of distal vessels. Cerebral infarction was associated with hydrocephalus ( p = .0019) and vasculitis ( p < .001). Conclusion In TBM, strokes are common and mainly involve the perforators and cortical branches. MR is the imaging modality of choice for early diagnosis and timely management.
Severe pulmonary hypertension and reduced right ventricle systolic function associated with maternal mortality in pregnant uncorrected congenital heart diseases
Authors: Hartopo Anggoro B. , Anggrahini Dyah W. , Nurdiati Detty S. , Emoto Noriaki , Dinarti Lucia K. 
Published: October 2019

BackgroundPregnant uncorrected congenital heart disease patients, especially those who already developed pulmonary hypertension, have increased risk for maternal mortality. The pulmonary hypertension severity and right ventricle function may be associated with higher maternal mortality. The study aimed to investigate the mortality rate of pregnant uncorrected congenital heart disease and the impact of pulmonary hypertension severity on mortality.MethodsThis is the sub study of COngenital HeARt Disease in adult and Pulmonary Hypertension Registry. The data of pregnant uncorrected congenital heart disease patients were analyzed from registry database. The maternal mortality was recorded. The data of demography, clinics, obstetrics, and transthoracic echocardiography were collected. The factors that influenced maternal mortality were analyzed. A statistical significance was determined when p value < 0.05.ResultsFrom 2012 until 2017, there were 78 pregnant congenital heart disease patients. Of them, 56 patients were eligible for analyses. The majority of congenital heart disease was atrial septal defect (91.1%). The maternal mortality rate was 10.7% (6 of 56). Pulmonary hypertension occurred in 48 patients, therefore the maternal mortality rate among congenital heart disease‐pulmonary hypertension with majority of atrial septal defect was 12.5% (6 of 48). Among nonsurvivors, 100% suffered from severe pulmonary hypertension as compared to survivors (56.0%), p = 0.041. Most nonsurvivors were Eisenmenger syndrome (83.3%), significantly higher compared to survivors (22.0%), p = 0.006. Nonsurvivors had significantly worsened WHO functional class, reduced right ventricle systolic function, and right heart failure. The modes of maternal death were severe oxygen desaturation (66.7%) and respiratory failure and sepsis (33.3%). Most of the maternal deaths occurred within 24 h postpartum period.ConclusionMaternal mortality rate among pregnant uncorrected congenital heart disease with majority of atrial septal defect was 10.7% and among congenital heart disease‐pulmonary hypertension with majority of atrial septal defect was 12.5%. Factors related with maternal mortality were severe pulmonary hypertension, Eisenmenger syndrome, and reduced right ventricle systolic function.
To enhance the quality of CPR performed by youth layman
Authors: Abelsson Anna , Nygårdh Annette 
Published: October 2019

Abstract

Background
By educating laymen, survival after cardiac arrest can increase in society. It is difficult to reach the entire population with cardiopulmonary resuscitation (CPR) training. However, if 15% of the population knows how to perform CPR, an increase in short- and long-term survival in patients suffering a cardiac arrest could be seen. To educate youth is a way to reach parts of the population. This study aimed to investigate the effect of a 2-h CPR intervention for youth.

Methods
Data were collected through an intervention utilizing simulation and consisted of a pre- and post-assessment of 50 participants’ CPR performance.

Results
The participants’ compression depths are, after training, within guidelines. However, the compression rate increases from within limits (117) to become too fast (128). The range of the minimum compression rate rises from 70 to 92 which is an improvement. The ventilation volume increases from 112 ml in pre-test to 579 ml in post-test. In the pre-test, 88% of the participants did not succeed in securing an open airway; only six participants succeeded in securing an open airway. In the post-test, 49% of the participants underperform in the ventilation. However, only 12 participants failed in securing an open airway in the post-test. Compression recoil and hand position marginally improved from pre- to post-test.

Conclusion
Educating young people at school is one way to disseminate CPR knowledge in society. In this study, the ventilation of the patient arose as a major weakness. To be able to establish an open airway and ventilate the patient with the correct volume as well as to overcome the psychological barrier to initiate mouth-to-mouth ventilation seems to require more than 2 h training. The training may need to consist of repeated sessions over the year with feedback, to give young people the skills to perform CPR with good quality.
The association between residential density and physical activity among urban adults in regional China
Authors: Wang Zhiyong , Qin Zhenzhen , He Jing , Ma Yuyang , Ye Qing , Xiong Yaqing , Xu Fei 
Published: October 2019

Abstract

Background
Studies from Western countries reported a positive relationship between residential density (RD) and physical activity (PA) among adults. There was no such study from China, a rapidly-urbanizing country in the world. This study aimed to investigate the RD-PA association among urban adults in China.

Methods
A multistage sampling approach was used to randomly select participants (aged 35–74 years old) in urban areas of Nanjing in 2017. The outcome variable was PA (dichotomized into “sufficient” or “insufficient”), while the independent variable was RD (tertiled into three sub-groups). Odds ratios (OR) and 95% confidence interval (CI) were computed to examine the RD-PA association using mixed-effects logistic regression models with adjustment for age, sex, nationality, marriage, educational attainment, employment status, body weight status, green space and neighborhood-level clustering effects.

Results
Of the 1568 eligible participants, 1551 were interviewed (response rate = 98.9%), with the mean age (standard deviation) of 54.7 (11.1) years old, and 46% of men. After adjustment for potential confounders and community-level clustering effects, participants lived in communities with higher (OR = 0.31, 95% CI = 0.21, 0.47) and middle (OR = 0.70, 95% CI = 0.50, 0.99) residential density were significantly less likely to achieve sufficient physical activity relative to their counterparts lived in the lower densed communities. Similar negative RD-PA association was examined for men or women, separately. The difference in the ORs between the middle and higher RD tertiles was also statistically significant (P < 0.01).

Conclusions
A negatively gradient RD-PA association, independent of body weight status and green space, was observed among urban adults in regional China. It has public health implications for China to help residents’ promote and maintain physical activity through planning and constructing PA−/health-friendly built environment in future.
Primary hepatic leiomyoma in a Chinese female patient without underlying disease: a case report
Authors: Jia Baoxing , Jin Zhe , Gao Pin , Liu Yahui 
Published: October 2019

Abstract

Background
Primary hepatic leiomyoma (PHL) is a rare manifestation of tumors in the liver; it is mainly characterized by its origin in the mesenchymal tissue. To date, the mechanisms underlying the pathogenesis of this disease remain unclear, however most reported PHL patients suffer from acquired immunity deficiency syndrome (AIDS) or take immunosuppressive medications after organ transplantation.

Case presentation
In this case report we describe a rare case of PHL in a middle-aged Chinese woman who was asymptomatic with no history of hepatitis or other liver disease. She had no history of immune suppression medication therapy. In view of the benign features of the hepatic lesion, along with our implementation of the respecting the patience choices, a laparoscopic partial hepatectomy of the right lower liver was performed, which appeared to be highly effective and give a good prognosis.

Conclusions
Clinical characteristics of the patient should be compared to previously reported aspects of this disease to reach a clear diagnosis. Moreover, although PHL is extremely rare, it should still be considered a possibility. Surgical intervention is effective in treating this disease.