bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of cost of component replacement versus entire device replacement during artificial urinary sphincter revision surgery
Authors: Yarlagadda Vidhush K. , Kilgore Meredith L. , Selph John P. 
Published: February 2018

AimTo identify the costs of replacing an entire malfunctioning AUS device versus an individual component at the time of device malfunction.MethodsDecision analysis was performed by analyzing the costs associated with revising a malfunctioning artificial urinary sphincter using one of two techniques: either individual or entire device replacement. Costs were determined by including actual institutional costs. Model assumptions were based on a summary of published literature and were created based on a time horizon of 0‐5 years since the original, primary AUS was placed, and models were created for malfunction of each individual component. Sensitivity analysis was done adjusting for costs of the device and failure rates.ResultsTotal costs to replace an individual component were $8330 for the pump, $7611 for the cuff, and $5599 for the balloon, while entire device replacement cost $15 069. Over a 5‐year time horizon the cost per patient for replacement of a balloon, pump, or cuff were $14 407, $17 491, and $15 212, respectively, versus $18 001 if the entire device was replaced. To be less costly to replace the entire device, balloon, pump, and cuff failure rates would need to be >55%, >25%, or >37.5% during the first 2 years after placement.ConclusionIn the event of failure of the artificial urinary sphincter, cost analysis demonstrates that removal and replacement of the entire device is more expensive than replacement of a malfunctioning component at any point up to 5 years after initial AUS placement.
Clinical outcomes of non‐surgical management of detrusor leak point pressures above 40 cm water in adults with congenital neurogenic bladder
Authors: Lane Giulia I. , Gor Ronak A. , Katorski Jenna , Elliott Sean P. 
Published: February 2018

AimsNeurogenic bladders (NGB) with detrusor leak point pressures >40 cm H2O (dLPP > 40) have been associated with deterioration of renal function in children with myelomeningocele. For these children, careful pressure management preserves renal function. However, similar evidence is lacking in adult congenital urology (ACU) patients with NGB. We describe renal functional outcomes of non‐surgical management of adults with dLPP > 40 or premicturition detrusor pressure (PMDP) >40 cm H2O, consisting of close follow‐up with urodynamic studies (UDS) and renal ultrasound (RUS), paired with adjustments to clean intermittent catheterization (CIC) frequency, anticholinergics, and addition of onabotulinumtoxinA toxin (BTX) injection.MethodsWe retrospectively reviewed the UDS of all patients at an ACU clinic from 2011 to 2016. Patients with dLPP/PMDP > 40 cm who elected for non‐surgical management were included. We describe their management and renal functional outcomes.ResultsA total of 33/42 patients with dLPP/PMDP > 40 elected for non‐surgical management. 28/33 (85%) were successfully managed without bladder augmentation or urinary diversion at follow‐up of nearly 3 years. The median index dLPP/PMDP was 49 cm H2O (IQR 44, 63) and final dLPP/PMDP was 28 (IQR 18, 43). There was a significant decrease in dLPP/PMDP and increase in bladder compliance between index and final UDS (P < 0.001). No patients advanced their CKD stage and 6/10 with baseline hydronephrosis had improvement or resolution of hydronephrosis with non‐surgical management.ConclusionsA non‐surgical protocol for ACU patients with NGB and dLPP/PMDP > 40, utilizing CIC, anticholinergics, and BTX is safe and effective when coupled with coordinated care and close follow‐up.
Satellite constellation design for forest fire monitoring via a stochastic programing approach
Authors: Hoskins Aaron B. , Medal Hugh R. , Rashidi Eghbal 
Published: February 2018

AbstractThere is significant value in the data collected by satellites during and after a natural disaster. The current operating paradigm in practice is for satellites to passively collect data when they happen to fly over a disaster location. Conversely, this article considers the alternative approach of actively maneuvering satellites to fly directly overhead of the disaster site on a routine basis. Toward this end, we seek to compute a satellite constellation design that minimizes the expected maneuver costs for monitoring an unknown forest fire. In this article, we present a 2‐stage stochastic programing model for this problem as well as a accelerated L‐shaped decomposition approach. A comparison between our approach and the current operating paradigm indicates that our solution provides longer duration data collections and a greater number of data collections. Analysis also shows that our proposed solution is robust over a wide array of scenarios.
Methyl Perillate as a Highly Functionalized Natural Starting Material for Terephthalic Acid
Authors: Jongedijk Esmer , van der Klis Frits , de Zwart Rozemarijn , van Es Daan S. , Beekwilder Jules 
Published: February 2018

AbstractRenewable commodity chemicals can be generated from plant materials. Often abundant materials such as sugars are used for this purpose. However, these lack appropriate functionalities and, therefore, they require extensive chemical modifications before they can be used as commodity chemicals. The plant kingdom is capable of producing an almost endless variety of compounds, including compounds with highly appropriate functionalities, but these are often not available in high quantities. It has been demonstrated that it is possible to produce functionalized plant compounds on a large scale by fermentation in microorganisms. This opens up the potential to exploit plant compounds that are less abundant, but functionally resemble commodity chemicals more closely. To elaborate this concept, we demonstrate the suitability of a highly functionalized plant compound, methyl perillate, as a precursor for the commodity chemical terephthalic acid.
Impact of Florida's prescription drug monitoring program and pill mill law on high‐risk patients: A comparative interrupted time series analysis
Authors: Chang Hsien‐Yen , Murimi Irene , Faul Mark , Rutkow Lainie , Alexander G. Caleb 
Published: February 2018

AbstractPurposeWe quantified the effects of Florida's prescription drug monitoring program and pill mill law on high‐risk patients.MethodsWe used QuintilesIMS LRx Lifelink data to identify patients receiving prescription opioids in Florida (intervention state, N: 1.13 million) and Georgia (control state, N: 0.54 million). The preintervention, intervention, and postintervention periods were July 2010 to June 2011, July 2011 to September 2011, and October 2011 to September 2012. We identified 3 types of high‐risk patients: (1) concomitant users: patients with concomitant use of benzodiazepines and opioids; (2) chronic users: long‐term, high‐dose, opioid users; and (3) opioid shoppers: patients receiving opioids from multiple sources. We compared changes in opioid prescriptions between Florida and Georgia before and after policy implementation among high‐risk/low‐risk patients. Our monthly measures included (1) average morphine milligram equivalent per transaction, (2) total opioid volume across all prescriptions, (3) average days supplied per transaction, and (4) total number of opioid prescriptions dispensed.ResultsAmong opioid‐receiving individuals in Florida, 6.62% were concomitant users, 1.96% were chronic users, and 0.46% were opioid shoppers. Following policy implementation, Florida's high‐risk patients experienced relative reductions in morphine milligram equivalent (opioid shoppers: −1.08 mg/month, 95% confidence interval [CI] −1.62 to −0.54), total opioid volume (chronic users: −4.58 kg/month, CI −5.41 to −3.76), and number of dispensed opioid prescriptions (concomitant users: −640 prescriptions/month, CI −950 to −340). Low‐risk patients generally did not experience statistically significantly relative reductions.ConclusionsCompared with Georgia, Florida's prescription drug monitoring program and pill mill law were associated with large relative reductions in prescription opioid utilization among high‐risk patients.
Patterns of prednisone use during pregnancy in women with rheumatoid arthritis: Daily and cumulative dose
Authors: Palmsten Kristin , Rolland Matthieu , Hebert Mary F. , Clowse Megan E.B. , Schatz Michael , Xu Ronghui , Chambers Christina D. 
Published: February 2018

AbstractPurposeTo characterize prednisone use in pregnant women with rheumatoid arthritis using individual‐level heat‐maps and clustering individual trajectories of prednisone dose, and to evaluate the association between prednisone dose trajectory groups and gestational length.MethodsThis study included pregnant women with rheumatoid arthritis who enrolled in the MotherToBaby Autoimmune Diseases in Pregnancy Study (2003–2014) before gestational week 20 and reported prednisone use without another oral glucocorticoid during pregnancy (n = 254). Information on medication use and pregnancy outcomes was collected by telephone interview plus by medical record review. Prednisone daily dose and cumulative dose were plotted by gestational day using a heat map for each individual. K‐means clustering was used to cluster individual trajectories of prednisone dose into groups. The associations between trajectory group and demographics, disease severity measured by the Health Assessment Questionnaire at enrollment, and gestational length were evaluated.ResultsWomen used prednisone 3 to 292 days during pregnancy, with daily doses ranging from <1 to 60 mg. Total cumulative dose ranged from 8 to 6225 mg. Disease severity, non‐biologic disease modifying anti‐rheumatic drug use, and gestational length varied significantly by trajectory group. After adjusting for disease severity, non‐biologic disease modifying anti‐rheumatic drug use, and other covariates, the highest vs lowest daily dose trajectory group was associated with reduced gestational age at delivery (β: −2.3 weeks (95%: −3.4, −1.3)), as was the highest vs lowest cumulative dose trajectory group (β: −2.6 weeks (95%: −3.6, −1.5)).ConclusionsIn pregnant women with rheumatoid arthritis, patterns of higher prednisone dose were associated with shorter gestational length compared with lower dose.
Agreement between paternal self‐reported medication use and records from a national prescription database
Authors: Cohen Jacqueline M. , Wood Mollie E. , Hernandez‐Diaz Sonia , Nordeng Hedvig 
Published: February 2018

AbstractPurposeFather's medication use is of interest in fertility studies and as negative control exposures in pregnancy medication safety studies. We sought to compare self‐report to prescription records to understand how reliably each of these sources of information may be used.MethodsWe compared self‐reported medication use in the 6 months prior to pregnancy from fathers participating in the Norwegian Mother and Child Cohort Study to records of dispensed prescriptions from the Norwegian Prescription Database that overlapped in time. Medications from 3 main categories were assessed: prescription medications used chronically, prescription medications used episodically, and over‐the‐counter/prescription medications (predominantly obtained without prescription). We calculated agreement between self‐report and dispensing records using Cohen's kappa statistic.ResultsWe included 42 848 pregnancies with the father's prescription data available for the 9 months before pregnancy. Prescription medications used chronically including antiepileptics, antipsychotics, and antidepressants showed substantial agreement between self‐report and prescription records: kappa statistics 0.87, 0.63, and 0.74, respectively. Prescription medications used episodically like anti‐infectives, opioids, anxiolytics, and hypnotics and sedatives showed worse agreement: kappa 0.19, 0.32, 0.40, 0.32. Over‐the‐counter/prescription medications like paracetamol and nonsteroidal anti‐inflammatory drugs had slight agreement: kappa 0.02 and 0.20.ConclusionsThere is good agreement between paternal self‐report and prescription data for prescribed medications used chronically and substantially less for medications used episodically. Suboptimal agreement for episodic medications suggests poor recall (for questionnaires) or false positives due to noncompliance (prescription data). Not surprisingly, use of medications available both with and without a prescription is not well captured using prescription databases alone.
Changes in consumption of opioid analgesics in Israel 2009 to 2016: An update focusing on oxycodone and fentanyl formulations
Authors: Ponizovsky Alexander M. , Marom Eli , Weizman Abraham , Schwartzberg Eyal 
Published: February 2018

AbstractPurposeThe purpose of the study is to assess opioid (morphine, methadone, oxycodone, pethidine, and fentanyl) consumption in Israel during 2009 to 2016 and identify recent trends.MethodsData for all treatment settings, private and public, for the years 2009 to 2016, were extracted from the Israel Ministry of Health's Pharmaceutical Administration database. The data were used to calculate defined daily doses (DDD) per 1000 inhabitants per day, of the various drugs.ResultsConsumption of the 5 opioids increased by 68%, from 3.40 DDD/1000 inhabitants/day in 2009 to 5.72 DDD/1000 inhabitants/day in 2016. This trend resulted mostly from increases in oxycodone consumption from 0.50 DDD/1000 inhabitants/day to 2.03 DDD/1000 inhabitants/day (namely, 4‐fold) and in fentanyl consumption, from 1.09 DDD/1000 inhabitants/day to 2.33 DDD/1000 inhabitants/day (about 2‐fold). The use of the 3 remaining opioids decreased substantially as follows: pethidine from 0.03 DDD/1000/day in 2009 to 0.007 DDD/1000 inhabitants/day in 2016 (−67%), methadone from 1.61 DDD/1000 inhabitants/day to 1.20 DDD/1000 inhabitants/day (−25%), and morphine from 0.17 DDD/1000 inhabitants/day to 0.15 DDD/1000 inhabitants/day (−12%). An increasing trend was also observed in the use of oxycodone/naloxone (Targin) and oxycodone/acetaminophen (Percocet) combinations, while a decrease was observed in the use of pure oxycodone formulations.ConclusionsThe increase in opioid consumption persisted throughout the years 2009 to 2016. This has been associated with substantial changes in the patterns of prescribing opioids, characterized by increases in oxycodone and fentanyl prescriptions and decreases in morphine, methadone, and pethidine prescriptions. A national program aiming to ensure safe use of opioids in the treatment of chronic pain is warranted.
Synthesis and characterization of petroleum and biobased epoxy resins: a review
Authors: Kumar Sudheer , Krishnan Sukhila , Mohanty Smita , Nayak Sanjay Kumar 
Published: February 2018

AbstractPetroleum based epoxy resins exhibit various excellent properties such as adhesion, mechanical performance, electrical insulation and chemical resistance. There is wide concern towards depletion of non‐renewable resources, climate change and finding renewable alternatives for petroleum based materials to reduce the emission of greenhouse gases. This review mainly draws attention towards the utilization of renewable resource based epoxy resin derived from lignocellulosic biomass, furan, tannins, itaconic acid, rosin acid and bio‐oil etc. Without altering the mechanical and thermal properties much, epoxy resins derived from renewable materials have been widely investigated. The last two decades have witnessed an exponential growth in using bio‐derived products, which has been driven by the need to replace petroleum based materials, reduce fuel consumption and lower the overall environmental impact. © 2018 Society of Chemical Industry
Gelating abilities of metal salts of ricinelaidic acid. Structural and rheological considerations
Authors: Zhang Mohan , Weiss Richard G. 
Published: February 2018

AbstractThe gelating abilities of metal salts of ricinelaidic acid (D‐REA), the trans isomer of the naturally occurring cis isomer, D‐ricinoleic acid, have been examined in a wide range of liquids. D‐REA is not a good gelator due to its bent shape and low melting temperature. Although upon the formation of metal salts aids aggregation of D‐REA, their gelating ability differs dramatically depending on the nature of the metal cation. The salts with nickel(II), copper(II), and zinc(II) are inefficient gelators, while the calcium salt can gelate various organic liquids and the sodium salt is an ambidextrous gelator. Also, gels of calcium and sodium salts in nitrobenzene and/or in water are among the few known examples with crystalline gelator networks that exhibit thixotropic behavior. Structural insights from FT‐IR and powder X‐ray diffraction indicate that the specific nature of interactions of the salts at their head groups leads to different packing arrangements and changes the strength of the driving forces for 1D growth from secondary interactions. A short comparison between the gelating abilities of the D‐REA and the corresponding salts from 9,10‐dioxooctadecanoic acid, an acid of related structure, is included as well. Insights into the relationships among the interactions at the metal carboxylate centers, their ability to form molecular gels, and the properties of their aggregated structures are provided.
Assessment of the wish to hasten death in patients with advanced cancer: A comparison of 2 different approaches
Authors: Bellido‐Pérez Mercedes , Crespo Iris , Wilson Keith G. , Porta‐Sales Josep , Balaguer Albert , Monforte‐Royo Cristina 
Published: February 2018

AbstractIntroductionThe Desire for Death Rating Scale (DDRS) and the short form of the Schedule of Attitudes toward Hastened Death (SAHD‐5) are different approaches to assessing the wish to hasten death (WTHD). Both have clinical threshold scores for identifying individuals with a meaningfully elevated WTHD. However, the agreement between the 2 measures and patient opinions about assessment of the WTHD are unknown.ObjectivesTo compare the DDRS and SAHD‐5 and to analyze patient opinions about assessment of the WTHD.MethodsThe WTHD was assessed in 107 patients with advanced cancer using both the DDRS and SAHD‐5. Patients were subsequently asked their opinion about this assessment.ResultsCorrelation between scores on the SAHD‐5 and the DDRS was moderate, Spearman rho = 0.67 (P < .01). The SAHD‐5 identified 13 patients (12.1%) at risk of the WTHD, and the DDRS identified 6 patients (5.6%) with a moderate‐high WTHD (P > .05). Concordance between the DDRS and SAHD‐5 in identifying individuals with an elevated WTHD was poor when using recommended cut‐off scores, κ = 0.37 (P < 0.01) but could be improved by using different thresholds. Only 4 patients (3.8%) regarded the assessment questions as bothersome, and 90.6% considered it important that health‐care professionals inquire about the WTHD.ConclusionsThe SAHD‐5 and DDRS appear to be appropriate methods for assessing the WTHD and could provide complementary information in clinical practice: the SAHD‐5 to screen for risk of the WTHD and the DDRS as a clinical interview to explore it in greater detail. Assessment of the WTHD is well accepted by palliative care cancer patients.
Social network, autonomy, and adherence correlates of future time perspective in patients with head and neck cancer
Authors: Baldensperger Linda , Wiedemann Amelie U. , Wessel Lauri , Keilholz Ulrich , Knoll Nina 
Published: February 2018

AbstractObjectiveSocioemotional selectivity theory proposes that, with more limited future time perspective (FTP), the meaning of individual life goals shifts from instrumental and long‐term goals, such as autonomy, to emotionally meaningful and short‐term life goals, especially concerning meaningful social relationships. Adverse side effects of cancer therapy may conflict with the realization of emotionally meaningful goals leading to nonadherence. In line with the theoretical assumptions, this study aimed to investigate (a) associations among disease symptoms, physical and cognitive limitations, and FTP and (b) among FTP, family network size, striving for autonomy, and treatment adherence.MethodOne hundred fifty‐seven patients (43‐90 years; 75% male) with head and/or neck cancer of a German University Medical Centre completed a questionnaire measuring FTP, age, disease symptoms, physical and cognitive functioning, family network size, and treatment adherence. Autonomy was assessed with a card sort task.ResultsA structural equation model yielded an acceptable fit χ2 (28) = 44.41, P = .025, χ2/df = 1.59, root mean square error of approximation = 0.06 (90% CI = 0.02, 0.09), Tucker‐Lewis Index = 0.92, and Comparative Fit Index = 0.96. An increased level of disease symptoms and physical and cognitive limitations was related to a shorter subjective FTP. Furthermore, individuals with a limited FTP reported a smaller family network, a lowered quest for autonomy, and lower treatment adherence.ConclusionsHypotheses derived from socioemotional selectivity theory were supported by the data. Longitudinal investigations should follow to corroborate findings and to focus on underlying mechanisms as improving patients FTP may play a crucial role in future disease management programs.
Discrete Scale Invariance in Holography Revisited
Authors: Flory Mario 
Published: February 2018

AbstractIn 2013, Balasubramanian presented a 5 + 1 dimensional holographic toy model that allows for an exact solution to Einstein's equations in the bulk in which the isometries of appear to be broken to an isometry group describing a discretely scale invariant and Poincaré invariant setup. In this paper, we investigate this solution in more detail. By analytically solving the Killing equations, we prove that the full isometry group is still present, although in a somewhat hidden way. We will also comment on the prospects of finding other holographic bottom up toy models which allow for solutions with discrete scale invariance or scale invariance without conformal invariance in the future.
Molecular identification of four novel cytochrome P450 genes related to the development of resistance of Spodoptera exigua (Lepidoptera: Noctuidae) to chlorantraniliprole
Authors: Wang Xuegui , Chen Yiqu , Gong Changwei , Yao Xinge , Jiang Chunxian , Yang Qunfang 
Published: February 2018

AbstractBACKGROUNDThe beet armyworm, Spodoptera exigua, is an omnivorous insect that damages a variety of crops worldwide. Chlorantraniliprole is a new diamide insecticide that acts on the ryanodine receptors in insects. The aim of this study was to explore key genes related to the development of chlorantraniliprole resistance in S. exigua.RESULTSTranscriptomes were compared between beet armyworms from a susceptible laboratory strain (Sus‐Lab) and Sus‐Lab screened with LC25 sublethal doses of chlorantraniliprole for six generations (SE‐Sel). Ten of 11 cytochrome P450 genes with upregulated expression verified by quantitative reverse transcription polymerase chain reaction (qRT‐PCR) in SE‐Sel strains were detected in SE‐PZ16 and SE‐ZY16, two extremely resistant field populations. In addition, expression of four new cytochrome P450 genes, CYP9A21v1, CYP9A21v2, CYP9A21v3 and CYP9A21v4, was shown in the two field populations and was significantly higher in the SE‐Sel strain than in the Sus‐Lab strain (P < 0.05). Their full‐length and protein tertiary structures were also cloned and predicted. The function of CYP9A21v3 was analysed by RNA interference, and the relative expression of CYP9A21v3 in the SE‐ZY16 population after feeding on dsRNA was lower than in the control group. Moreover, mortality rates in insects treated at the LC50 of chlorantraniliprole after dsRNA feeding were significantly higher than in the control group 24 h after treatment (P < 0.05).CONCLUSIONOverexpression of CYP9A21v3 may be a primary factor in the development of chlorantraniliprole resistance in beet armyworms. © 2018 Society of Chemical Industry