bluuebunny/crossref_metadata_2025_split huggingface dataset:
HYPK scaffolds the Nedd8 and LC3 proteins to initiate formation of autophagosome around polyneddylated huntingtin exon1 aggregates
Authors: Ghosh Debasish Kumar , Ranjan Akash 
Published: September 2019

ABSTRACTSelective degradation of protein aggregates by autophagy is an essential homeostatic process of safeguarding cells from the effects of proteotoxicity. Among the ubiquitin-like modifier proteins, Nedd8 conjugation to misfolded proteins is prominent in stress-induced protein aggregates, albeit the function of neddylation in autophagy is unclear. Here, we report that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein aggregates. We also show that HYPK functions as an autophagy receptor in the polyneddylation-dependent aggrephagy. The scaffolding function of HYPK is facilitated by its C-terminal ubiquitin-associated domain and N-terminal tyrosine-type LC3 interacting region which bind to Nedd8 and LC3 respectively. Both Nedd8 and HYPK are positive modulators of basal and induced-autophagy, leading to desensitizing cells from protein aggregates, such as aggregates of mutant huntingtin-exon1. Thus, we propose an additive role of neddylation and HYPK in clearance of protein aggregates by autophagy, resulting in cytoprotective effect during proteotoxic stress.
Hue tuning curves in V4 change with visual context
Authors: Benjamin Ari S. , Ramkumar Pavan , Fernandes Hugo , Smith Matthew , Kording Konrad P. 
Published: September 2019

AbstractNeurons are often probed by presenting a set of stimuli that vary along one dimension (e.g. color) and quantifying how this stimulus property affect neural activity. An open question, in particular where higher-level areas are involved, is how much tuning measured with one stimulus set reveals about tuning to a new set. Here we ask this question by estimating tuning to hue in macaque V4 from a set of natural scenes and a set of simple color stimuli. We found that hue tuning was strong in each dataset but was not correlated across the datasets, a finding expected if neurons have strong mixed selectivity. We also show how such mixed selectivity may be useful for transmitting information about multiple dimensions of the world. Our finding suggest that tuning in higher visual areas measured with simple stimuli may thus not generalize to naturalistic stimuli.New & NoteworthyVisual cortex is often investigated by mapping neural tuning to variables selected by the researcher such as color. How much does this approach tell us a neuron’s general ‘role’ in vision? Here we show that for strongly hue-tuned neurons in V4, estimating hue tuning from artificial stimuli does not reveal the hue tuning in the context of natural scenes. We show how models of optimal information processing suggest that such mixed selectivity maximizes information transmission.
Long-read-based Human Genomic Structural Variation Detection with cuteSV
Authors: Jiang Tao , Liu Bo , Jiang Yue , Li Junyi , Gao Yan , Cui Zhe , Liu Yadong , Wang Yadong 
Published: September 2019

AbstractLong-read sequencing enables the comprehensive discovery of structural variations (SVs). However, it is still non-trivial to achieve high sensitivity and performance simultaneously due to the complex SV characteristics implied by noisy long reads. Therefore, we propose cuteSV, a sensitive, fast and scalable long-read-based SV detection approach. cuteSV uses tailored methods to collect the signatures of various types of SVs and employs a clustering-and-refinement method to analyze the signatures to implement sensitive SV detection. Benchmarks on real PacBio and ONT datasets demonstrate that cuteSV has better yields and scalability than state-of-the-art tools. cuteSV is available at https://github.com/tjiangHIT/cuteSV.
Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers
Authors: Markunas Christina A. , Semick Stephen A. , Quach Bryan C. , Tao Ran , Deep-Soboslay Amy , Bierut Laura J. , Hyde Thomas M. , Kleinman Joel E. , Johnson Eric O. , Jaffe Andrew E. , Hancock Dana B. 
Published: September 2019

ABSTRACTNumerous DNA methylation (DNAm) biomarkers of cigarette smoking have been identified in peripheral blood studies, but their relevance as neurobiological indicators is unknown due to DNAm tissue-specificity. In contrast, blood-based studies may not detect brain-specific smoking-related DNAm differences that may provide greater insight into the neurobiology of smoking behaviors. We report the first epigenome-wide association study (EWAS) of smoking in human postmortem brain, focusing on nucleus accumbens (NAc) as a key brain region in developing addiction. Following Illumina HumanMethylation EPIC array data generation and quality control, 221 decedents (120 European American [23% current smokers], 101 African American [26% current smokers]) were analyzed. DNAm by smoking (current vs. nonsmoking) was tested using robust linear regression models adjusted for age, sex, cell-type proportion, DNAm-derived negative control principal components (PCs), and genotype-derived PCs. Separate ancestry-specific results were combined via meta-analysis, resulting in 7 CpGs that exceeded false discovery rate (FDR)<0.05. Using published smoking EWAS results in blood, we extended our NAc findings to identify DNAm smoking effects that are unique (tissue-specific) versus shared between tissues (tissue-shared). Of the 7 CpGs identified in NAc, 3 CpGs were located near genes previously indicated with blood-based smoking DNAm biomarkers: ZIC1, ZCCHC24, and PRKDC. The other 4 CpGs are novel for smoking-related DNAm changes: ABLIM3, APCDD1L, MTMR6, and CTCF. Our results provide the first evidence for smoking-related DNAm changes in human NAc, highlighting CpGs that were previously undetected as peripheral biomarkers and may reflect brain-specific processes.
PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks
Authors: Alonso-de Vega Ignacio , Paz-Cabrera M. Cristina , Wiegant Wouter W. , Checa-Rodríguez Cintia , Huertas Pablo , Freire Raimundo , van Attikum Haico , Smits Veronique A.J. 
Published: September 2019

ABSTRACTPost-translational histone modifications and chromatin remodelling play a critical role in the mechanisms controlling the integrity of the genome. Here we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating the balance between DNA damage-induced focus formation by 53BP1 and BRCA1, critical factors in the pathway choice for DNA double strand break repair. PHF2 knock down leads to impaired BRCA1 focus formation and delays the resolution of 53BP1 foci. Moreover, irradiation-induced RPA phosphorylation and focus formation, as well as localization of CtIP, required for DNA end resection, to sites of DNA lesions are affected by depletion of PHF2. These results are indicative of a defective resection of double strand breaks and thereby an impaired homologous recombination upon PHF2 depletion. In accordance with these data, Rad51 focus formation and homology-directed double strand break repair is inhibited in cells depleted for PHF2. Importantly, we demonstrate that PHF2 knock down decreases CtIP and BRCA1 protein and mRNA levels and cells depleted of PHF2 display genome instability and are sensitive to the inhibition of PARP. Together these results demonstrate that PHF2 promotes DNA repair by homologous recombination by controlling CtIP-dependent resection of double strand breaks.
Corporate tax disclosure on a CSR basis: a new reporting framework in the post-BEPS era
Authors: De la Cuesta-González Marta , Pardo Eva 
Published: September 2019

PurposeThe purpose of this paper is to explore the emerging discourse on corporate taxation from a corporate social responsibility perspective to develop a consensual definition of corporate tax responsibility (CTR) and to identify a set of indicators that firms should publicly communicate to their stakeholders as an accountability mechanism.Design/methodology/approachData were obtained from semi-structured interviews with representatives of stakeholders closely related to taxation: tax authorities, companies, NGOs, tax advisors and academics. Based on a discourse analysis approach, data were coded and analyzed using computer-assisted qualitative data analysis software.FindingsCTR is defined as the set of tax-related practices and policies that allow companies to pay a fair share of taxes as a function of the generated value in each jurisdiction in which they operate and to then publicly disclose them. Disclosure should cover disaggregated quantitative data and information on practices and policies.Originality/valueDespite the wealth of research on sustainability reporting and increasing public awareness of tax aggressiveness and disclosure, academic research has not explored tax-responsible reporting. Moreover, no consensual definition of CTR has been formulated, and no indicators to properly account for responsible taxation have been identified. This paper contributes to filling these gaps by providing rich interview evidence regarding the nature of the emerging discourse on CTR reporting and a set of material indicators for CTR disclosure. This paper encourages researchers to foster the development of social accountability by engaging in future empirical studies of CTR.
A scheme for the sticky policy representation supporting secure cyber-threat intelligence analysis and sharing
Authors: Osliak Oleksii , Saracino Andrea , Martinelli Fabio 
Published: September 2019

Purpose
This paper aims to propose a structured threat information expression (STIX)-based data representation for privacy-preserving data analysis to report format and semantics of specific data types and to represent sticky policies in the format of embedded human-readable data sharing agreements (DSAs). More specifically, the authors exploit and extend the STIX standard to represent in a structured way analysis-ready pieces of data and the attached privacy policies.

Design/methodology/approach
The whole scheme is designed to be completely compatible with the STIX 2.0 standard for cyber-threat intelligence (CTI) representation. The proposed scheme will be implemented in this work by defining the complete scheme for representing an email, which is more expressive than the standard one defined for STIX, designed specifically for spam email analysis.

Findings
Moreover, the paper provides a new scheme for general DSA representation that has been practically applied for the process of encoding specific attributes in different CTI reports.

Research limitations/implications
Because of the chosen approach, the research results may have limitations. Specifically, current practice for entity recognition has the limitation that was discovered during the research. However, its effect on process time was minimized and the way for improvement was proposed.

Originality/value
This paper has covered the existing gap including the lack of generality in DSA representation for privacy-preserving analysis of structured CTI. Therefore, the new model for DSA representation was introduced, as well as its practical implementation.
Leveraging open-standard interorganizational information systems for process adaptability and alignment
Authors: Pu Xiaodie , Chong Alain Yee Loong , Cai Zhao , Lim Ming K. , Tan Kim Hua 
Published: September 2019

PurposeThe purpose of this paper is to understand the value creation mechanisms of open-standard inter-organizational information system (OSIOS), which is a key technology to achieve Industry 4.0. Specifically, this study investigates how the internal assimilation and external diffusion of OSIOS help manufactures facilitate process adaptability and alignment in supply chain network.Design/methodology/approachA survey instrument was designed and administrated to collect data for this research. Using three-stage least squares estimation, the authors empirically tested a number of hypothesized relationships based on a sample of 308 manufacturing firms in China.FindingsThe results of the study show that OSIOS can perform as value creation mechanisms to enable process adaptability and alignment. In addition, the impact of OSIOS internal assimilation is inversely U-shaped where the positive effect on process adaptability will become negative after an extremum point is reached.Originality/valueThis study contributes to the existing literature by providing insights on how OSIOS can improve supply chain integration and thus promote the achievement of industry 4.0. By revealing a U-shaped relationship between OSIOS assimilation and process adaptability, this study fills previous research gap by advancing the understanding on the value creation mechanisms of information systems deployment.
Unemployment and self-rated health in Ghana: are there gender differences?
Authors: Sulemana Iddisah , Anarfo Ebenezer Bugri , Doabil Louis 
Published: September 2019

Purpose
A large extant literature examines the association between unemployment and self-rated health. Most of these studies reveal that unemployment diminishes self-rated health. Another strand of this literature, albeit sparse, suggests that the relationship between unemployment and self-rated health is gendered. The purpose of this paper is twofold: first, to examine whether unemployment is correlated with self-rated health in Ghana; and second, to explore whether and to what extent men differ from women on the basis of this relationship.

Design/methodology/approach
The authors used data from the Wave 6 of World Values Survey in Ghana (n=1552) and probit and instrumental variable probit regressions to empirically examine the association between unemployment and self-rated health in Ghana.

Findings
The results confirm that unemployment is negatively correlated with self-rated health among Ghanaians. Specifically, the unemployed are about 6.84–7.20 percent less likely to report good health status in a pooled sample. Further, after correcting for endogeneity, unemployed men are about 26.68 percent less likely to report good health. However, the association is not statistically significant for unemployed women.

Originality/value
The study contributes to the literature by providing empirical evidence from Ghana.
Power-based behaviors between supply chain partners of diverse national and organizational cultures: the crucial role of boundary spanners’ cultural intelligence
Authors: Murphy Wiliam H. , Gölgeci Ismail , Johnston David A. 
Published: September 2019

Purpose
This paper aims to explain the effects of national and organizational cultures of boundary spanners on their choices of using three archetype power-based behaviors – dominance, egalitarian and submissive – with supply chain partners. Improved outcomes for global supply chain (GSC) partners are anticipated due to the ways that cultural intelligence affects these culturally guided decisions.

Design/methodology/approach
Drawing on multiple streams of literature and focusing on boundary spanners in GSCs, the authors build a conceptual framework that highlights cultural antecedents of predispositions toward power-based behaviors and explains the moderating role of cultural intelligence of boundary spanners on behaviors performed.

Findings
The authors propose that boundary spanners’ national and organizational cultural values influence predispositions toward applying and accepting power-based behaviors. They also discuss how cultural intelligence moderates the relationship between culturally determined predispositions and power-based behaviors applied by partners. The cultural intelligence of boundary spanners is argued to have a pivotal role in making power-based decisions, resulting in healthier cross-cultural buyer–supplier relationships.

Originality/value
This paper is the first paper to advance an understanding of the cultural antecedents of boundary spanners’ power-based behaviors that are exercised and interpreted by partners in GSCs. Furthermore, the potential role of cultural intelligence in inter-organizational power dynamics and power-based partner behaviors in supply chains has not previously been discussed.
Reputational risk management in conditions of credibility gap in the banking system
Authors: Trostianska Karyna , Semencha Ilona 
Published: September 2019

Purpose
This paper aims to provide appropriate and effective methods for diagnosing and managing the reputational risk of a bank.

Design/methodology/approach
Using the data-mining system CONFOR, the authors have defined and arranged in the objective way the factors influencing the reputational risk level of a bank, with specific factor groups assigned. The mathematical tools of the theory of graphs and cognitive mapping are used for building the cognitive map of reputational risk assessment of a bank. To enable choosing which risk management strategies to use, the methods of impulse modeling and scenario analysis are applied for the purpose of prognostication.

Findings
The authors proposed an integrated approach to the objective determination of the reputational risk level and an easy-to-use choice of risk management scenarios considering all components of management decision making and the main managerial functions.

Practical implications
The range of tools proposed can be used as a simple measure of the bank's reputational risk level, as a component of risk management model, and as a strategic risk management tool. Implementing this approach at the level of the central bank will facilitate realization of its strategic program for restoring confidence in the banking system as a whole.

Originality/value
A relatively greater objectivity in the reputational risk assessment of the bank was achieved, with each stage formalized and confirmed by an economic and mathematical basis, risk parameters quantified. The authors have developed a comprehensive approach to the reputational risk level assessment (the integral assessment included) as well as the management algorithm.
J. Walter Thompson: the origin and development of account planning
Authors: Sánchez-Blanco Cristina 
Published: September 2019

Purpose
This paper aims to clarify whether J. Walter Thompson (JWT)’s planning and research tradition gave rise to the concept of Account Planning. In addition, it seeks to analyse the different planning methodologies that preceded Account Planning to highlight how it emerged at JWT London. A further goal is to understand the impact of Account Planning, which sought to achieve effective advertising through detailed consumer insight and has transformed the multinational JWT as a whole and the advertising sector in general.

Design/methodology/approach
The methodology is based mainly on the analysis of primary research conducted on original files donated to Duke University Library (North Carolina, USA) by the multinational J. Walter Thompson.

Findings
Account Planning emerged in 1968 in London as a consequence of the research and planning tradition that already existed at JWT. JWT’s corporate culture established the importance of the Account Planning approach that was valued by advertisers and spread to all offices. The planning tools used by the multinational today are updated versions of those that were designed from 1960 onwards.

Research limitations/implications
The historical approach taken here precludes an analysis of the current reality of Account Planning. In future research, it would be useful to carry out in-depth interviews with professionals to explore how they apply planning tools that represent updated versions of those that were developed 50 years ago.

Originality/value
This paper’s main interest lies in the fact that it is based on original, unpublished sources, an approach that makes it possible to reassess previous findings.
A systematic mapping study on gamification applied to e-marketing
Authors: Noorbehbahani Fakhroddin , Salehi Fereshteh , Jafar Zadeh Reza 
Published: September 2019

Purpose
Today, marketing has evolved due to the emergence of new electronic technologies and has shifted to e-marketing. Meanwhile, the gamification and gamified systems is an up-to-date research topic that has attracted the attention of many researchers in recent years. As one of the main goals of marketing is to increase customer engagement and loyalty by persuading and motivating them to participate, the gamification has a great potential for e-marketing. Although much research has been done on the gamification subject in e-marketing, there has not yet been a comprehensive review of these studies. This paper aims to provide a comprehensive overview of the scientific and practical research on gamification applied to e-marketing using the systematic mapping study methodology.

Design/methodology/approach
Because considerable research has been devoted to gamification since 2011, and the number of papers published in this area has grown steadily from 2011, the paper reviews the publications over the period 2011-2018. The research method includes developing research questions, designing the research process and filtering the findings based on the specified criteria.

Findings
The findings of this study show the main applications of gamification in e-marketing, the technologies used and the proven benefits of applying this technique in e-marketing. It also provides a classification of the studies in this area.

Practical implications
This paper helps other researchers to understand the main areas of research in gamification within the marketing discipline and enables them to find the fields needed for future studies.

Originality/value
The proposed classification can give a comprehensive overview of the scientific and practical actions taken on gamification applied to e-marketing for academics and practitioners. It also enables the readers to find main areas of research and motivates them to apply gamification in e-marketing.
Selection of technology standardization mode for libraries based on game theory
Authors: Jiang Hong , Xu Hongtao , Zhao Shukuan , Chen Yong 
Published: September 2019

Purpose
Internet of Things (IoT), a strategic emerging industry, has brought a new driving force to the global economic growth, as well as an effective solution to break the barrier of economic development. However, standards system of IoT is not yet mature, existing obvious overlapping and even conflicting standards, and enterprises lack mature technology standardization model, which severely restricts the structural upgrading and development of IoT. The paper aims to discuss these issues.

Design/methodology/approach
In this regard, this study combs the research context of the IoT, technology standardization and competition behavior, and analyze technology standardization models of IoT by combining theory with practice. Using game theory and profit function, this paper analyzes the selection mechanism of standardization model of IoT enterprises, and explores practical application of these models using competitive behavior theory.

Findings
First, in the process of standardization, technology standardization model n enterprises is not single, nor is it immutable. Second, the trend of internationalization of technical standards is becoming more and more obvious. Third, if LoT enterprises want to achieve their own technology standardization, the corresponding competitive behavior is essential. Fourth, with the change of innovation capability and market forces, the competitive behavior of enterprises should be improved accordingly to better adapt to the changes of internal and external environment and ensure the realization of the standardization of enterprises. Fifth, if IoT attempts to achieve the same globalization as the internet, there must be a set of support systems.

Originality/value
Finally, some suggestions are given for the future development in the field of IoT. This study will provide some theoretical support for promoting the development of standards and enhancing the competitiveness of IoT enterprises.