bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacological Activities of Warm Alkaline Hydrogen Peroxide Solution and Therapeutic Potential in Medicine: Physical-Chemical Reprofiling as a Promising Lead for Drug Discovery
Authors: Urakova Natalya , Urakov Aleksandr , Shabanov Petr 
Published: December 2024

Abstract:
The traditional use of antiseptics, chemotherapeutic, expectorant, mucolytic drugs, and oxygen gas by artificial ventilation does not effectively eliminate hypoxemia in sputum, mucus, pus, and blood asphyxia in COVID-19. The emergency conversion of sputum, mucus, pus, and blood into oxygenated foam inside the airways utilizing the enzyme catalase and warm alkaline hydrogen solutions (WAHPSs) is proposed as a promising area for new therapeutic development.. The possibility of physical-chemical repurposing of hydrogen peroxide from an antiseptic in pyolytics, mucolytics, hemolytics, and oxygen-producing antihypoxants by con-verting a cold, acidic non-carbonated drug into an oxygen-saturated WAHPS and its intrap-ulmonary injection is pointed out as a way to solve this problem. The possibility of medically enriching blood oxygen in hypoxemia by catalase cleavage of hydrogen peroxide when WAHPSs are administered orally as energy drinks or directly into the blood as injections is pointed out. The fact is that virtually all human tissues are rich in catalase, which immediately breaks down hydrogen peroxide into water and oxygen gas. Inhalation and/or intrapulmonary injections of WAHPSs have been shown to provide intra-airway interaction with catalase in sputum, mucus, pus and/or blood and releases oxygen gas, which foams the biological masses, is absorbed into the blood and eliminates hypoxemia. Thus, the physical-chemical repurposing of known drugs can be considered a promising direction for the discovery of new drugs.
Value of the data:
1) Why are these data useful?
These studies indicate that the enzyme catalase, which is present in many tissues of animals and humans in both normal and disease, can be employed to enrich the tissues with oxygen and eradicate hypoxia when hydrogen peroxide solution is injected into them..
2) Who can benefit from these data?
Mountaineers, divers, submarine sailors, miners, astronauts, traumatologists, resuscitators, car-diologists, transplantologists, pulmonologists, obstetricians and gynecologists, emergency phy-sicians, EMERCOM personnel, and medical workers, providing emergency medical care in cases of smoke in rooms, lack of oxygen in the inhaled air, drowning, bronchial asthma attack, acute respiratory distress syndrome, and asphyxia can use the data presented in this article.
3) How can these data be used/reused for further insights or development of experi-ments?
These data can be used to develop new antihypoxants, to improve methods of increasing the organism's endurance to hypoxia, methods of organ and tissue preservation, methods of ische-mia treatment, methods of emergency medical care in urgent conditions, methods of ARDS treatment and standards of medical care.
FDA Novel Approvals of Pharmaceuticals, 2013-2022: An Observational Study
Authors: Misra Saurav , Shukla Ajay Kumar 
Published: December 2024

Background:
Novel drugs often mean new patient treatment options and advances in health care for humanity. This study, which delves into the trends of drug approvals by the FDA in the last decade, from CY 2013 to 2022, is of significant importance to the medical community and policymakers in the pharmaceutical industry.

Methods:
US-FDA's free, open-source, online database for novel drug approvals from 2013 to 2022 was used. FDA novel drug approvals were analysed from calendar year (CY) 2013 to 2022 based on their numbers and impact, innovation, access, and predictability.

Results:
The total number of drugs approved from CY 2013 to 2022 was 428 (average of 43 novel drugs/ year). 40% were first-in-class drugs. Access to novel drug approvals: 87% were first-cycle approvals, and 72% were approved in the US before other countries. Drug approv-al statistics: 26% priority reviews, 12% breakthrough approval, 16% fast track approval and 12% expedited approval among novel drug approvals. Predictability of novel drug approvals: 98% of approvals can meet PDUFA goal dates for application review. The most common drug class was anticancer drug (26%), and the most common administration route was oral (86%). One hundred two drugs have been approved with black box warnings, and 25 FDCs (Fixed dose combinations) were approved from 2013 to 2022.

Conclusions:
The novel drug approvals during CY 2013-2022 were of high quality, as evi-denced by their high impact, good access, and high predictability. Our study provides a com-prehensive insight into FDA-approved drugs, offering valuable information to the medical community and policymakers in the pharmaceutical industry.
NOMES EM –NTE: RECATEGORIZAÇÃO DO PARTICÍPIO PRESENTE E FLUIDEZ CATEGORIAL
Authors: Da Silva Cordeiro Fernando , Balduíno Bispo Edvaldo 
Published: December 2024

Analisamos, neste artigo, o uso de nomes em –nte, instâncias da construção [[X]V –nte]N, cuja origem é o particípio presente latino. Objetivamos discutir a recategorização do particípio presente em nome e a flutuação categorial que os nomes em –nte apresentam entre as categorias de substantivo e adjetivo, considerando propriedades formais e funcionais desses nomes bem como motivações e mecanismos envolvidos nesses processos. Fundamentamo-nos na Linguística Funcional Centrada no Uso (FURTADO DA CUNHA; BISPO, 2013). Metodologicamente, trata-se de uma pesquisa qualitativa, com suporte quantitativo, e descritivo-explicativa quanto a seus objetivos. Os dados são oriundos de amostras do português escrito entre os séculos XIII e XX, o que evidencia o viés diacrônico da pesquisa. A recategorização do particípio presente foi um processo de mudança multidirecional que se deu ainda no latim possivelmente pela perda de traços da categoria de particípio, pela mudança de paradigma do sufixo –nte e pela exaptação do particípio presente. A flutuação categorial exibida entre os nomes em –nte é motivada pela contiguidade das categorias de substantivo e adjetivo, o que implica um mapeamento metonímico. A neoanálise é o principal mecanismo de mudança envolvido nos dois casos.
CONTEXTUALIZAÇÃO DO OBJETO CIENTÍFICO DA ARQUIVOLOGIA
Authors: Luiz Josenilda Santos 
Published: December 2024

SCHMIDT, Clarissa Moreira dos Santos. Objeto científico da Arquivologia - Reflexão para o debate. In: Projeto SESA ON-LINE. 2020. Disponível em https://www.youtube.com/watch?v=CjIVT0RDZKU&list=PLxN9uB8ODjKmszvX0wANWVEQ0Zx6X8HYw&index=11 Acesso em 20 de dez. 2021.
REINSERINDO A CLASSIFICAÇÃO NO DEBATE ARQUIVÍSTICO
Authors: Moreira dos Santos Schmidt Clarissa 
Published: December 2024

Este artigo apresenta reflexões acerca dos objetivos, importância e termos vinculados à “função classificação”, também denominada “classificação arquivística”. Em perspectiva metodológica partiu-se da pesquisa qualitativa que se apoiou em revisão bibliográfica sobre a classificação em arquivos. Como resultados, constata-se que a Arquivologia necessita aprofundar suas teorias e práticas em classificação, pois ao não situar exatamente em que campo se insere seu trabalho de organização de arquivos e a que tipo de construção de conhecimento serve, incorre no risco de delimitar e exercer uma classificação arquivística arbitrária e subjetiva, incapaz de representar o contexto de produção dos documentos, seus significados e capacidade probatória.
DIREITO HUMANO À MEMÓRIA E À VERDADE
Authors: De Araújo Lima Rogério , Guimarães Carvalho Maria Elizete 
Published: December 2024

O presente trabalho objetiva propor um debate em torno do direito à memória e à verdade em tempos de transição. Para a construção dessa escritura, buscamos desenvolver as seguintes questões: o que vem a ser o direito à memória e à verdade? Quais eventos históricos ilustram a luta pela consagração desse direito? Por que o debate atual é urgente e necessário? Para tentar respondê-las, amparámo-nos, do ponto de vista teórico e metodológico, na bibliografia e na legislação referenciada ao final do texto. Assim, adotamos a metodologia de revisão bibliográfica e a abordagem hermenêutica da legislação pátria e internacional correspondente. O produto da investigação tem como resultado preliminar a atualidade e urgência do debate, a importância do caso “Gomes Lund versus Brasil” e a consequente instauração das comissões da verdade em solo brasileiro, bem como os desafios oriundos dos surtos autoritários que assolam o país neste momento.
A construção do corpus de artigos científicos de aviação:
Authors: Morais Fernanda Beatriz Caricari de , Santos João Paulo Martins dos 
Published: December 2024

This article presents the experience of building a corpus of scientific articles written in English in the field of aviation, and the linguistic-computational treatment given by the [...] and the linguistic-computational treatment given by Corpus Linguistics. Data collection was performed using computer programming techniques for data scraping, which allowed the collection of articles from two electronic journals: Air & Space Power Journal and Journal of Aviation/Aerospace Education and Research. The corpus is used for linguistic research, based on Systemic-Functional Linguistics (Halliday, 1994 e Halliday & Matthiessen, 2004, 2014), that sees language as a potential system of meanings, in which the concept of choice is essential for allowing the study of lexical regularities, and has implications for both language description and language teaching. With the use of Corpus Linguistics computational tools (Berber-Sardinha, 2000, 2004), it is possible to work with a large number of texts, obtaining quantitative data that help in the qualitative analysis of these regularities. As a result, we have a study corpus that can be considered "[...] medium-large (Berber-Sardinha, 2004), with more than three million words. It is expected that the construction of this corpus will encourage new linguistic and statistical research in aviation, especially involving cadets who participate in scientific initiation programs and who draft their course completion papers.
EFEKTIVITAS PENGGUNAAN TELEMEDICINE PASCA PANDEMI COVID-19
Authors: Mizaniah Silmi , Larasati Anindita , Keumalahayati Nahra , Haifa Nida Wafiq , Herbawani Chahya Kharin 
Published: December 2024

Latar Belakang: Munculnya Pandemi Covid-19 memberikan suatu perubahan secara signifikan terhadap penggunaan telemedicine sehingga menunjukan adanya perilaku berbeda yang dilakukan oleh masyarakat. Dalam situasi tersebut, menimbulkan adanya peningkatan dalam penggunaan telemedicine dikarenakan pandemi mempengaruhi minat masyarakat terhadap penggunaan layanan telemedicine yang berkelanjutan sampai pada situasi pasca pandemi Covid-19 saat ini. Tujuan: Penelitian ini memiliki tujuan untuk membahas mengenai efektivitas penggunaan telemedicine pasca pandemi Covid-19 dengan fokus pada manfaat, tantangan, dan implikasi penggunaan telemedicine dalam pelayanan kesehatan saat ini. Metode: Metode penelitian ini adalah studi kepustakaan (systematic review) dengan penulusaran literatur. Hasil: Hasil penelitian menunjukan bahwa adanya efektivitas penggunaan telemedicine pasca pandemi Covid-19 dari segi manfaat, tantangan yang dihadapi, serta implikasi penggunaan telemedicine. Kesimpulan: Simpulan penelitian ini menunjukan bahwa peningkatan pengguna telemedicine secara signifikan diakibatkan karena adanya efektifitas telemedicine pasca pandemi Covid-19 seperti mempermudah akses pelayanan kesehatan dan meringankan biaya pengeluaran. Selain manfaat yang dapat diterima para pengguna telemedicine tidak menutup kemungkinan bahwa adanya tantangan dalam penggunaan telemedicine seperti keterbatasan pengetahuan teknologi, keterbatasan pemeriksaan fisik, serta kondisi geografis maupun sosio-demografi
Effect of Codigestion of Rice Straw, Fish Meal, and Cow Manure on Biogas Production and Quality of Solid Bioslurry Fertilizer
Authors: Damayanti Sri Ismiyati , Hakim Rifki Amirul , Anggraeni Anggi , Saputri Yuni 
Published: December 2024

The solid phase bioslurry (sludge) had the potential to be used as organic fertilizer. However, the NPK content in it did not meet SNI standards. This research aimed to study the effect of adding rice straw and fish meal to cow dung substrate for anaerobic processing, on the NPK content of the sludge produced and biogas production. Two digesters were used, which functioned as a control and a codigestion digester. Initially, in both digesters, starter breeding was carried out in batches. After the starter had grew well, then the substrate along with water was fed continuously at 88 mL/day in each digester, and an output of 88 mL/day was also produced. Analysis of COD, sCOD, VFA concentrations, and measurements of the pH values of feed and output were carried out every 3 days. Biogas volume measurements were carried out every day. The process was stopped when conditions were steady. At the end of the process, an analysis of the NPK content in the sludge and the methane content in the biogas were carried out. The results showed that biogas from codigestion content almost no methane. However, the sludge contained NPK within the range of SNI standard. Keywords: Biogas, Cow dung, Fish meal, Rice straw, Solid bioslurry fertilizer.
Female Perspectives sebagai Representasi Karya Foto Mahasiswa Perempuan
Authors: Suratni Suratni , Widiastuti Ni Made , Suwarni Wahyu , Amelia Diah 
Published: December 2024

ABSTRACT In 2024, the Photography Study Program at Politeknik Negeri Media Kreatif will be 14 years old. This study program has produced hundreds of skilled photographer alumni who work in the creative industry. Every year, students hold a number of exhibitions to actualize their works. One of them is an exhibition of photos by female students called the Women's Exhibition. This article aims to explain how a photobook becomes a medium of representation of female student photography. The references used are several previous studies with the same focus on discussion. The method used is qualitative descriptive, with a photo curation technique from the results of the Women's Exhibition. Various interpretations on women are embodied in dozens of photo works which are then compiled into a photobook entitled Female Perspectives, which has six categories, namely (1) female beauty perspectives, (2) female food perspectives, (3) female profession perspectives, (4) female traveling perspectives, (5) female sport and healthy perspectives, and (6) female lifestyle perspectives. With the publication of this photobook, female students can represent their opinions on today's women in the form of a photobook, so that they can get their artistic value and economic value.Keywords: women's perspectives, photobook, representation, student work ABSTRAKTahun 2024, Prodi Fotografi di Politeknik Negeri Media Kreatif genap berusia 14 tahun. Prodi ini telah mencetak ratusan alumni fotografer terampil yang berkarya di bidang industri kreatif. Setiap tahunnya, mahasiswa menggelar sejumlah pameran untuk mengaktualisasikan karya-karya mereka. Salah satunya adalah pameran foto karya mahasiswa perempuan yang diberi nama Pameran Perempuan. Artikel ini bertujuan untuk menjelaskan bagaimana photobook menjadi media representasi karya foto mahasiswa perempuan. Referensi yang digunakan adalah beberapa penelitian terdahulu dengan fokus pembahasan yang sama. Metode yang digunakan adalah kualitatif deskriptif, dengan teknik kurasi foto dari hasil Pameran Perempuan. Berbagai pandangan tentang perempuan diwujudkan dalam puluhan karya foto yang kemudian disusun menjadi sebuah photobook yang berjudul Female Perspectives, yang memiliki enam kategori, yaitu (1) female beauty perspectives, (2) female food perspectives, (3) female profession perspectives, (4) female travelling perspectives, (5) female sport and healthy perspectives, and (6) female lifestyle perspectives. Dengan diterbitkannya photobook ini, mahasiswa perempuan dapat merepresentasikan pandangan mereka tentang perempuan masa kini dalam bentuk photobook, sehingga didapat nilai seni dan nilai ekonomisnya. Kata kunci: pandangan perempuan, photobook, representasi, karya mahasiswa
Visibility in Graphs and Polygons
Authors:   , Brötzner Anna 
Published: December 2024

In this thesis, we investigate visibility in connection with path planning. We focus on two problems concerning the exploration of and the orientation in an environment.

The first problem we consider is the Watchperson Route Problem, in which mobile agents are deployed to monitor the interior of a 2-dimensional environment bounded by a polygon. The goal is to see (a) every part of, or (b) some points of interest in the environment at some point in time. To save resources, the route along which a mobile agent walks shall be as short as possible. We explore different variations of this problem, involving human vision as we know it, as well as a notion of vision that resembles that of a modem with the ability of seeing through some walls. Our research is driven by the question of finding an optimal solution―a shortest path―with efficient use of resources. As it turns out, some variations of the Watchperson Route Problem allow for computing optimal solutions with only short computation time, while other variations are provably difficult to solve optimally. For those variations that are hard to solve, we provide efficient algorithms to approximate optimal solutions.

In the second problem, we are given an odd number of points in the plane, and non-intersecting segments such that each segment connects two of the points, leaving only one point unmatched. We ask whether it is possible to reconfigure this arrangement into any other arrangement of equally many non-intersecting segments on the given point set by gradually adding and removing one segment in such a way that after each reconfiguration step, the number of segments remains constant and only one point is unmatched. To keep this transformation planar, the segments are viewed as obstacles in the plane, and the visibility between the unmatched point and the segment endpoints is used to determine possible transformations. We prove that there always exists a sequence of reconfiguration steps that allows us to transform any given set of segments into any other set of segments on the same set of endpoints.
Application of CVD Coated Turning Inserts in the Machining of ABNT 8620 Steel at Different Cutting Speeds
Authors: Silva Rodrigo Yudi Okochi Alves da , Silva Matheus Lopes da , Conti Pedro Henrique de Melo Cordeiro , Costa Anderson Figueiredo da 
Published: December 2024

Objective: The objective of this study is to analyze turning inserts by evaluating their wear when increasing the cutting speed.

Theoretical Framework: This topic presents the main concepts and theories that support the research. The use of CVD-coated turning inserts in the machining of ABNT 8620 steel stands out, reflecting scientific and technological advances that integrate several historical, cultural and social demands. Machining insert technology has been standing out for decades, and such research has led to an increase in the useful life of tools, in addition to ensuring a better surface finish and thermal control of the entire process. This ensures the industry savings in the use of inserts and results in reduced spending on purchasing new inputs and optimizes the material resources used.

Method: The methodology adopted for this research involves using turning inserts to evaluate their wear when increasing the cutting speed. The material used as the test specimen in question is ABNT 8620, which remains the standard in all tests. For each test, the WNMG060408-TM insert was used to analyze aspects such as power, temperature and vibration.

Results and Discussion: The results obtained revealed that by analyzing the machining chips, we can see that the formation of all of them was similar, and can be classified as spiral and not exceeding 40 mm, in the worst condition. This fact was to be expected and can be explained by the constant advance even with different cutting speeds, causing the material to remain within the chip formation zone.

Research Implications: The practical and theoretical implications of this research are discussed, providing insights into how the results can be applied or influenced so that regardless of cutting speed, chip formation remains consistent under similar cutting conditions.

Originality/Value: This study contributes to the literature due to the originality of the research, whether through an innovative approach, new discoveries or practical contributions. The relevance and value of this research are evidenced by the conclusion that the best cutting speed for this type of coating, insert and material is 350 m/min, having a better surface finish of the finished part, shorter chip length and a long contact time, providing the industry with a more aggressive cutting parameter and a good insert life, bringing with it greater productivity for the process.
Regionalizmy krakowskie w języku młodzieży – znajomość wybranych leksemów
Authors: Klimasara Patrycja 
Published: December 2024

The aim of this article is to present the results of survey research that examined the familiarity with selected Krakow regionalisms. The study was inspired by the work of renowned linguists Jadwiga Kowalikowa and Sylwia Przęczek-Kisielak. The results obtained by the researchers were compared with those collected in April 2022. 100 respondents from a Krakow high school were asked about the meaning and associations of words such as “kaflarz,” “fliziarz,” “andrus,” “łor,” “krakus,” “bajok,” “lajkonik,” “pedel,” “centuś,” and “kinder.” It was revealed that some of these words are still known to the youth, while others are understood differently than the definitions provided in the publication titled “Powiedziane po krakowsku. Słownik regionalizmów krakowskich,” Krakow 2019. It is emphasized that the discussed issue has not been fully explored, and its research prospects are extensive.
ОСОБЛИВОСТІ ФАХОВОЇ ПІДГОТОВКИ ВЧИТЕЛІВ ТЕХНОЛОГІЙ З ІСТОРІЇ ТРУДОВОГО ТА ПРОФЕСІЙНОГО НАВЧАННЯ
Authors: Кільдеров Дмитро , Логвиненко Анна 
Published: December 2024

У статті проведений аналітичний огляд фахової підготовки майбутніх учителів технологій в контексті вивчення історії трудового та професійного навчання. На підставі аналізу теоретичної та практичної підготовки вчителів запропоновано і проведено проєктування структури та змісту вибіркового курсу з означеної проблематики. Проведено обґрунтування змісту цієї навчальної дисципліни як системотвірної ланки формування у студентів знань історії трудового і професійного навчання. Структуровано вивчення курсу, в якому передбачено у форматі двох змістових модулів, перший з яких “Історія становлення трудового та професійного навчання”, а другий – “Розвиток трудового та професійного навчання у період 1917 рік по даний час”.
ДЕЯКІ АСПЕКТИ ПРОБЛЕМИ СТАТЕВОГО ВИХОВАННЯ ДІТЕЙ ТА ЮНАЦТВА В ЗАГАЛЬНООСВІТНІХ ШКОЛАХ ЗАКОРДОННЯ
Authors: Сливка Лариса 
Published: December 2024

Дослідження присвячено висвітленню низки теоретичних положень і напрямів практичної реалізації статевого виховання учнів у школах держав європейського континенту. Схарактеризовано чинники, які актуалізують проблему статевого виховання дітей та юнацтва. Відзначено ефективність програм статевого виховання учнів, які впроваджують в освітній процес закладів загальної середньої освіти. Представлено назви базових документів щодо проєктування змісту, методів і форм статевого виховання, як-от: “Стандарти статевої освіти в Європі”, “Основи комплексної статевої освіти”, “Керівництвo з розробки політики в галузі статевих і репродуктивних прав молодих людей у Європі”, “Технічне керівництво зі статевої освіти” та ін. Встановлено, що європейські учені й практики розрізняють три моделі статевого виховання ‒ ристриктивну, пермісивну, модель під назвою “золота середина”. Констатовано, що жодна з них не є ані гіршою, ані кращою за інші.