bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of ecotoxicological effects of ciprofloxacin in Daphnia magna: life-history traits, biochemical and genotoxic effects
Authors: Nunes B. , Leal C. , Rodrigues S. , Antunes S. C. 
Published: June 2018

Abstract
Antibiotics (e.g. ciprofloxacin) have been detected in surface water and groundwater for several decades. In order to understand the potential impact of the continuous exposure of aquatic organisms to ciprofloxacin, a chronic assay was carried out with Daphnia magna. This approach allowed evaluation of the effects of ciprofloxacin on life-history and sub-individual parameters (antioxidant status and metabolic response: activities of catalase and glutathione S-transferases – GSTs; peroxidative damage; thiobarbituric acid reactive substances and genotoxic effects (genetic damage index, measured by the comet assay). Life-history parameters of D. magna showed no significant effects after ciprofloxacin exposure. Concerning oxidative stress and metabolism parameters, no significant alterations were reported for catalase and GSTs activities. However, a dual response was observed, with a significant decrease in lipid peroxidation levels at low ciprofloxacin concentrations (&lt;0.013 mg/L), while a significant increase was verified at high ciprofloxacin concentrations (0.078 mg/L). The genotoxicity assay detected a significant increase in genetic damage index up to 0.013 mg/L of ciprofloxacin. The here-tested ciprofloxacin concentrations, which are ecologically relevant, did not cause significant impacts concerning the life-history parameters of D. magna; however, at the same levels of ciprofloxacin an oxidative stress and genotoxic damage scenarios were recorded.
Dual Inhibitors as a New Challenge for Cancer Multidrug Resistance Treatment
Authors: Stanković Tijana , Dinić Jelena , Podolski-Renić Ana , Musso Loana , Burić Sonja Stojković , Dallavalle Sabrina , Pešić Milica 
Published: June 2018

Background:Dual-targeting in cancer treatment by a single drug is an unconventional approach in relation to drug combinations. The rationale for the development of dualtargeting agents is to overcome incomplete efficacy and drug resistance frequently present when applying individual targeting agents. Consequently, -a more favorable outcome of cancer treatment is expected with dual-targeting strategies.Methods:We reviewed the literature, concentrating on the association between clinically relevant and/or novel dual inhibitors with the potential to modulate multidrug resistant phenotype of cancer cells, particularly the activity of P-glycoprotein. A balanced analysis of content was performed to emphasize the most important findings and optimize the structure of this review.Results:Two-hundred and forty-five papers were included in the review. The introductory part was interpreted by 9 papers. Tyrosine kinase inhibitors’ role in the inhibition of Pglycoprotein and chemosensitization was illustrated by 87 papers. The contribution of naturalbased compounds in overcoming multidrug resistance was reviewed using 92 papers, while specific dual inhibitors acting against microtubule assembling and/or topoisomerases were described with 55 papers. Eleven papers gave an insight into a novel and less explored approach with hybrid drugs. Their influence on P-glycoprotein and multidrug resistance was also evaluated.Conclusion:These findings bring into focus rational anticancer strategies with dual-targeting agents. Most evaluated synthetic and natural drugs showed a great potential in chemosensitization. Further steps in this direction are needed for the optimization of anticancer treatment.
O mar, a nau, a batalha: a sobrevivência das formas na 'Antologia da memória poética da Guerra Colonial'
Authors: Vasconcellos Lisa Carvalho 
Published: June 2018

A Antologia da memória poética da guerra colonial, livro publicado pelos lusitanistas Roberto Vecchi e Margarida Calafate Ribeiro em 2011, é o mais recente esforço no sentido de coletar e dar significado ao enorme corpus poético que foi produzido a partir dos conflitos travados entre Portugal e suas ex-colônias nas décadas de 1960 e 70. Entre os muitos eixos temáti­cos e formais que atravessam os poemas e poéticas recolhidos no livro, o resgate e a reproposição da tradição literária portuguesa talvez sejam os principais. Nas mais de seiscentas páginas do volume, as tradições do pas­sado – as Cantigas de Amigo, as crônicas de navegação, a épica camoniana, as figuras históricas e os mitos heroicos – são revistas de modo crítico e inventivo. Mais do que uma releitura paródica do passado, a presença de elementos arcaicos e tradicionais na Antologia denota a sobrevivência de formas e tensões (cf. Aby Warburg) na cultura literária de Portugal, que se renova e reinventa a partir quase sempre das mesmas questões (o mar, a conquista, a saudade e a destruição).---DOI: http://dx.doi.org/10.22409/abriluff.2018n20a483
Sena, Sophia, Magalhães: sobre a poesia portuguesa antes e depois da Revolução de 74
Authors: Roriz Paloma 
Published: June 2018

Realizando um breve apanhado da situação da poesia portuguesa a partir do final da década de 1920, fomentada em grande parte por linhas de estratégias de recusa e diálogo com a herança modernista de Fernando Pessoa e da geração de Orpheu, o presente artigo procura refletir como alguns projetos estéticos e ideológicos, operados pelos poetas Jorge de Sena, Sophia de Mello Breyner e Joaquim Manuel Magalhaes, apresentam, em seus possíveis pontos de contato e divergência, diferentes formas de articulação critica entre história, ética e poesia.---DOI: http://dx.doi.org/10.22409/abriluff.2018n20a487
'Pretos e Brancos': Brito Camacho e o olhar antropológico da literatura colonial
Authors: Sousa Sandra 
Published: June 2018

Este artigo pretende explorar as ligações entre literatura colonial e antro­pologia durante as primeiras décadas do século XX. Através da análise da obra Pretos e Brancos (1926) de Brito Camacho é minha intenção demons­trar que algumas das obras vencedoras do Concurso de Literatura Colonial se encontram imbuídas de um olhar antropológico fazendo com que lite­ratura colonial e antropologia se tivessem constituído como dois “saberes” coloniais interligados desde a sua génese. Assim sendo, ambos os “saberes” – literário e antropológico –funcionaram no início do projeto colonial com o objetivo de construção e legitimação do império colonial português.---DOI: http://dx.doi.org/10.22409/abriluff.2018n20a494
O singular enfrentamento à ideologia colonial da colecção “autores ultramarinos ” da Casa dos Estudantes do Império
Authors: Mata Inocência Luciano dos Santos 
Published: June 2018

Tendo a CEI nascido sob os auspícios do então ministro das Colónias de Portugal, Vieira de Machado, como consagração da política de enaltecimento e defesa do império colonial, pode parecer paradoxal que uma instituição que era suposto funcionar como “triunfo do espírito português” pudesse gerar tantos cartuchos fracturantes da consciência histórica do regime. Um desses cartuchos, para além do Centro de Estudos Africanos (criado pelos estudantes da CEI, mas que não funcionava no espaço da CEI), foi a Colecção “Autores Ultramarinos”, em que, não obstante a designação, foram publicadas as obras mais emblemáticas da literatura anticolonial africana. O objectivo deste artigo é revelar os meandros dessa orientação editorial e a sua relação com a “questão colonial” e como ela funcionou como uma estratégia para enfrentar a violência da ideologia colonial cujo objectivo era a subalternização das identidades africanas.---DOI: http://dx.doi.org/10.22409/abriluff.2018n20a495
Doğru Taban Gübre Seçiminde İhmal Edilen Seçenek: 20.32.0.+15 (SO3) + Zn Gübresi ve Toprak Analiz Desteği
Authors: Kaplan Mustafa , Maltaş Ahmet Şafak 
Published: June 2018

Öngörü çalışmalarının zenginliği, çoğu zaman,
öngörü kalitesini artırır. Ancak Türkiye kimyasal gübre tüketimlerinin
geleceğine yönelik çalışmalar azdır. Bu makaleyle, 1999 yılında önerilen ve
2004 yılından itibaren üretilmeye başlanan bir kompoze gübrenin, henüz tahmin
edilen düzeyde tüketilmiyor olmasının neden ve sonuçları tartışılmıştır.
Türkiye’de çiftçiler özellikle hububat üretiminde ekim öncesi veya ekimle
gübrelemede çoğunlukla azot ve fosforu birlikte içeren kompoze gübreleri tercih
etmektedirler. Bu tercih, çiftçileri DAP
ve 20.20.0 kompoze gübrelerini yaygın olarak kullanmaya yönlendirmiştir. 1999
yılında önerdiğimiz, 2004 yılından bu
yana üretilen 20.32.0. 15(SO3)+Zn gübresi, bazı hububat alanları için çok daha
uygun azot fosfor dengesi sağlayan doğru bir alternatiftir. Ancak bilinirliği
çok sınırlıdır. Yıllık tüketim miktarının son 3 yıl ortalaması yaklaşık 19 bin
ton düzeyindedir ve bu durum beklentilerimizin altındadır. Toprak analizine
dayalı, nitelikli gübreleme tavsiyeleri sayısının artışı; bu ve bu gübredeki
N/P205 dengesine yakın özellikte üretilecek gübrelere
artan miktarlarda tüketim şansı verecektir. Olmasını beklediğimiz bu artış,
dengesiz azot-fosfor kullanıma bağlı ekonomik kayıpları azaltabilecektir. Bilgi
ve gözlemlerimizin hemen tamamı Türkiye’de toprak ve bitki analiz desteğinin
çok özel bir değere sahip olduğuna işaret etmektedir. Kimyasal gübre tüketim desteğinden daha
öncelikli olarak, toprak ve bitki analiz desteğinin uygulama kalitesi
geliştirilmelidir. Bu yolla gübrelemelerin analiz sonuçlarına dayalı olarak
yapılmasını gerçekleşebilecektir. Sonuçta kimyasal gübre kullanım etkinliği
artacaktır.
Bazı Çilek Çeşitlerinde Kök Bakterisi Uygulamalarının Meyve Verimi ve Verim Özellikleri Üzerine Etkileri
Authors: AĞGÜN Zarife , GEÇER Mustafa Kenan , ASLANTAŞ Rafet 
Published: June 2018

Bu çalışma farklı kök bakterilerinin (Azot-1,
Azot-2, Fosfor-1, Fosfor-2, Azot+Fosfor), 3 çilek çeşidinde (Albion, San
Andreas ve Monterey) verim ve bazı meyve özellikleri üzerine etkilerini
araştırmak amacıyla yapılmıştır. Çalışmada bakteri uygulamalarından meyve verimi üzerine en
etkili sonuç 99.88 g bitki-1 ile Fosfor-1 uygulamasından elde
edilmiştir. Bakteri uygulaması sonucunda çeşitler arasında en yüksek verim,
93.02 g bitki-1 ile San Andreas çeşidinden elde edilmiştir. Bakteri uygulamaları bakımından, en yüksek
meyve sayısı 3.48 adet bitki-1 ile Azot-1 uygulamasından elde
edilmiştir. Bunun yanında en fazla meyve sayısı 4.28 adet bitki-1
ile Monterey çeşidindeki Azot-1 grubundan elde edilmiştir. Bakteri
uygulamalarında ortalama meyve ağırlığı bakımından, en yüksek sonucu 30.17 g
meyve-1 ile Fosfor-2 uygulaması vermiştir. Aynı şekilde en yüksek
ortalama meyve ağırlığı 32.38 g meyve-1 ile San Andreas çeşidinde
Fosfor-2 uygulamasında belirlenmiştir. Suda çözünür kuru madde
içeriği açısından bakteri uygulamalarından en yüksek değer %10.02 ile
Azot-1 uygulamasında belirlenmiştir. Fosfor-2 uygulamasında en yüksek suda
çözünür kuru madde miktarı %10.98 ile Monterey çeşidinde elde edilmiştir.
Bakteri uygulamaları sonucu en yüksek pH değere 3.97 ile Azot-2 uygulamasından
ulaşılmıştır. İncelenen çilek çeşitleri arasında en yüksek pH 9.92 ile Albion
çeşidinde kontrol grubundan elde edilmiştir. Bakteri uygulamalarında en yüksek
titre edilir asitlik %0.92 ile Fosfor-2 uygulamasında belirlenmiştir. Çilek
çeşitlerinde ise en fazla titre edilir asit %1.18 ile San Andreas çeşidinde
Fosfor-2 uygulamasından elde edilmiştir. Çalışma sonucunda incelenen
parametreler bakımından kök bakterisi uygulamalarının verim ve kalite yönünden
faydalı olacağı düşünülmektedir.
SETTINGS OF TEMPERATURE AND TIME SAVING ON SEED GERMINATION OF Magnolia champaca (L.) Baill. ex Pierre
Authors: Nuradinda Odetta Maudy , Estuningsih Sri Pertiwi , Harmida Harmida 
Published: June 2018

Setting storage space temperature and time saving becomes an important application in supporting the development of plantations to provide seeds as needed and sustainable. The purpose of this research is to delay the rapid of seed germination in Magnolia champaca by assessing the effect of various suspend temperatures and times saving on seed germination of Magnolia camphaca . The research was conducted in Plant Physiology Laboratory, Department of Biology, Faculty of Mathematics and Natural Sciences, Sriwijaya University in February until June 2016. The method was used completely randomized design pattern Factorial by 3 factors with 12 treatments and 3 replications with the temperature: temperature ± 31°C, temperature ± 25 °C, temperature ± 18 °C, temperature ± 4 °C and the retention of time 0 week, 2 weeks , 4 weeks and 6 weeks. The parameters include the observation of germination rate, germination, vigor index and sprout morphology. The results of the research the treatment of interaction of temperature and time saving significantly affected on germination rate, germination and seed vigor index of Magnolia champaca. Germination speed, germination and vigor index were both produced by the treatment of storage at a temperature of ± 18 °C and a temperature of ± 25 °C at all times to keep (2 weeks, 4 weeks, 6 weeks) compared to control treatment. A normal sprout produced in temperature treatment ± 18 °C and ± 25 °C temperature ranges between 90-93%. An abnormal sprout produced in control treatment (0 week) by 25%. Measurement of moisture content and physiological maturity level of Magnolia champaca seed needs to be done before it is stored and germinated to test the viability of seeds of sprouts.
THE VALID SPECIES AND DISTRIBUTION OF STINGRAYS (Myliobatiformes: Dasyatidae) IN SOUTH SUMATERA WATERS, INDONESIA
Authors: Iqbal Muhammad , Zulkifli Hilda , Yustian Indra 
Published: June 2018

A recent study to providing valid checklist of stingrays species in South Sumatran waters provide 14 species: Brevitrygon heterura, Fluvitrygon kittipongi, Fluvitrygon oxyrhyncha, Fluvitrygon signifier, Fluvitrygon sp ‘musi’ 1, Fluvitrygon sp ‘musi’ 2, Himantura undulata, Himantura uarnak, Maculabatis gerrardi, Pateobatis fai, Pateobatis uarnacoides, Pastinachus ater, Telatrygon biasa and Urogymnus polylepis. Distributional patterns of stingrays in South Sumatran waters are depend on species or (at least) genus level. Stingrays in South Sumatran waters are recorded from of up to more 100 km inland to the coastal zone area. Following IUCN Red List status, 10 species of stingrays are threatened with status Endangered, Vulnerable and Data Deficient; suggest the South Sumatran waters are important habitat for stingrays in Indonesia.
Cannabis use predicts risks of heart failure and cerebrovascular accidents: results from the National Inpatient Sample
Authors: Kalla Aditi , Krishnamoorthy Parasuram M. , Gopalakrishnan Akshaya , Figueredo Vincent M. 
Published: June 2018

Background
Cannabis for medicinal and/or recreational purposes has been decriminalized in 28 states as of the 2016 election. In the remaining states, cannabis remains the most commonly used illicit drug. Cardiovascular effects of cannabis use are not well established due to a limited number of studies. We therefore utilized a large national database to examine the prevalence of cardiovascular risk factors and events amongst patients with cannabis use.

Methods
Patients aged 18–55 years with cannabis use were identified in the National Inpatient Sample 2009–2010 database using the Ninth Revision of International Classification of Disease code 304.3. Demographics, risk factors, and cardiovascular event rates were collected on these patients and compared with general population data.

Results
Prevalence of heart failure, cerebrovascular accident (CVA), coronary artery disease, sudden cardiac death, and hypertension were significantly higher in patients with cannabis use. After multivariate regression adjusting for age, sex, hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, tobacco use, and alcohol use, cannabis use remained an independent predictor of both heart failure (odds ratio = 1.1, 1.03–1.18, P < 0.01) and CVA (odds ratio = 1.24, 1.14–1.34, P < 0.001).

Conclusion
Cannabis use independently predicted the risks of heart failure and CVA in individuals 18–55 years old. With continued legalization of cannabis, potential cardiovascular effects and their underlying mechanisms need to be further investigated.
Ortofotografía digital y datos LIDAR para el control y administración del litoral en la isla de Tierra Bomba, Caribe colombiano
Authors: Franco Fernando Afanador , Gómez Mojica Juan Carlos , Orozco Quintero Fernando , Carvajal Díaz Andrés Felipe 
Published: June 2018

Como resultado de la presión antrópica sobre los litorales colombianos, principalmente sobre las playas y los terrenos de bajamar (aquellos comprendidos entre la más alta y la más baja marea), la Autoridad Marítima Nacional, representada por la Dirección General Marítima, ha definido y adoptado, un modelo conceptual basado, entre otros componentes, en la utilización de ortofotografías digitales y datos del sensor LiDAR (Light Detection And Ranging) para la producción de una base cartográfica digital sobre la cual se establezca técnicamente el límite de la jurisdicción de la Autoridad Marítima Nacional y se puedan llevar a cabo las labores de administración y control del litoral en la isla de Tierra Bomba.
La utilización de las dos técnicas de sensoramiento remoto (fotografía aérea y sensor aerotransportado LiDAR) en la isla de Tierra Bomba, comprendió las etapas de aplicación del modelo conceptual, la verificación de sus resultados en terreno, el análisis y discusión del límite preliminar de la jurisdicción de la DIMAR, el almacenamiento de la información espacial de jurisdicción en el SIG Institucional de la DIMAR y finalmente, el desarrollo del control y administración del litoral por parte de la Autoridad Marítima Nacional.
Los resultados obtenidos incluyeron, en primer lugar, la base cartográfica digital del área de estudio, compuesta por 28 ortofotomapas a escala 1:2000; la interpolación desde el Modelo Digital del Terreno- DTM generado con base en datos LiDAR, del valor de la altura elipsoidal de la línea de más alta marea en la zona de estudio; la identificación de 39 espolones alrededor de la isla; se reporta la presencia de 29 especies de vegetación costera pertenecientes a 18 familias distribuidas en 9 transectos; la posición espacial del límite interno de las playas; identificación y espacialización de 68 áreas sometidas a rellenos antrópicos (abarcando un área total de 23.23 ha) principalmente en los centros poblados de Caño del Oro y Bocachica; localización y cuantificación de las planicies de inundación por un eventual ascenso del nivel medio del mar (35.7 ha para un eventual ascenso de 30 cm y 331.1 ha para un ascenso de 100 cm); trazado del límite preliminar de la jurisdicción de la DIMAR y la estructuración y almacenamiento de la información espacial y alfanumérica en la Geodatabase Corporativa de la DIMAR.
En relación con los bienes de uso público, se estableció que 10.27 ha corresponden a playas; 273,74 ha a terrenos de bajamar y 228.66 ha a la franja de jurisdicción de cincuenta metros, para un total de bienes de uso público bajo jurisdicción de la DIMAR de 284.02 ha.
ПРОБЛЕМЫ ИННОВАЦИОННЫХ ТЕХНОЛОГИЙ В ПРОЦЕССЕ СТАНОВЛЕНИЯ ЦИФРОВОЙ ЭКОНОМИКИ РЕГИОНА
Authors: Гасанов Гасан Атабабаевич , Гасанов Тофик Атабабаевич , Фейзуллаев Фёдор Султанович 
Published: June 2018

Цель работы. Исследовать применение инновационных технологий в Республике Дагестан, причины, замедляющие их внедрение в сравнении с другими регионами, а также готовность региона к разработке программы «Цифровая экономика Республики Дагестан». Метод или методология проведения работы. На основе статистических методов исследования, научной абстракции, моделирования процессов развития инновационных технологий и планирования цифровой экономики выявить причинно-следственные связи, по которым еще не принята республиканская программа цифровизации экономики. Используя метод исторического и логического, проанализировать причины снижения темпов развития инновационных технологий за пять лет, а также исследовать внутренние и внешние факторы, влияющие на внедрение прогрессивных технологий и цифровой экономики в республике. Результаты. В процессе анализа статистических данных за пять лет по республике было выявлено резкое снижение темпов инновационной активности организаций (в %) и доли затрат на технологические инновации. Основными причинами такого положения дел в этой области инновационных технологий явились: отсутствие современной производственной базы у предприятий; нехватка финансовых средств или недостаточный объем финансирования их по статье «инновационные технологии»; экономические санкции Запада (в 2014 год), которые проявились в виде запущенного механизма импортозамещения, в том числе в области прогрессивных и инновационных технологий. Важным элементом становления цифровой экономики являются информационно-компьютерные и инновационные технологии. Медленные темпы развития инновационных технологий тормозят принятие программы цифровизации экономики республики, а это, в свою очередь, крайне негативно сказывается на развитии экономики республики, повышении материального благосостояния граждан и создании нового качества жизни. При отсутствии такой программы прогрессивные технологии в регионе не могут полноценно развиваться, так как они базируются на информационно-компьютерных технологиях. Отставание республики в этой области может затянуться не неопределенное время. Область применения результатов. Полученные результаты исследования могут быть использованы при составлении планов социально-экономического развития предприятия, при планировании программы цифровой экономики республики, учебных методик по цифровой экономике, в процессе преподавания «Экономической теории», в экспериментальных исследованиях. Выводы. Снижение темпов внедрения и инновационной активности организаций, удельного веса затрат на технологические инновации будут способствовать отставанию республики в развитии экономики, снижению уровня жизни населения. Кроме того, отсутствие программы по цифровой экономике негативно скажется на качестве жизни населения, медицинского обслуживания, предоставления образовательных услуг жителям республики.
СОЦИАЛЬНО-ЭКОЛОГИЧЕСКИЕ ПРИОРИТЕТЫ РАЗВИТИЯ СОВРЕМЕННОГО ЖИЛИЩНОГО СТРОИТЕЛЬСТВА
Authors: Швыденко Наталья Викторовна , Усаткина Ольга Игоревна 
Published: June 2018

Цель. На основе анализа тенденций развития инвестиционно-строительного комплекса сформулированы социально-экологические приоритеты развития современного жилищного строительства. Метод. В процессе исследования определены специфика инвестиционно-строительных экоустойчивых проектов, приоритеты градостроительной деятельности, базирующейся на принципах «зеленой» экономики. В работе обоснована необходимость строительства нового сегмента доступного, комфортного и экологического жилья на основе эффективного социального партнерства участников строительной отрасли, позволяющего получить синергетический эффект от качества действий партнеров на каждом этапе жизненного цикла жилого объекта. Результаты. Предложены схема реализации экосистемного подхода на этапах жизненного цикла жилого объекта, вариант структуры нормативно-правовой базы городского жилищного экостроительства для Ростовской области, градостроительные принципы и перспективы пространственной организации жилой застройки г. Ростова-на-Дону с учетом социально-экологических приоритетов. Область применения результатов. Результаты исследования могут быть использованы для совершенствования жилищного экостроительства на региональном и муниципальном уровнях. Выводы. Реализация представленных предложений позволит создать условия для развития массового строительства доступного, комфортного и экологического жилья, повышения качества жизни населения, улучшения городской среды и инновационного развития региона.