bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Tissue Factor for Immunotherapy of Triple-Negative Breast Cancer Using a Second-Generation ICON
Authors: Hu Zhiwei , Shen Rulong , Campbell Amanda , McMichael Elizabeth , Yu Lianbo , Ramaswamy Bhuvaneswari , London Cheryl A. , Xu Tian , Carson William E. 
Published: April 2018

Abstract
Triple-negative breast cancer (TNBC) is a leading cause of breast cancer death and is often associated with BRCA1 and BRCA2 mutation. Due to the lack of validated target molecules, no targeted therapy for TNBC is approved. Tissue factor (TF) is a common yet specific surface target receptor for cancer cells, tumor vascular endothelial cells, and cancer stem cells in several types of solid cancers, including breast cancer. Here, we report evidence supporting the idea that TF is a surface target in TNBC. We used in vitro cancer lines and in vivo tumor xenografts in mice, all with BRCA1 or BRCA2 mutations, derived from patients' tumors. We showed that TF is overexpressed on TNBC cells and tumor neovasculature in 50% to 85% of TNBC patients (n = 161) and in TNBC cell line–derived xenografts (CDX) and patient-derived xenografts (PDX) from mice, but was not detected in adjacent normal breast tissue. We then describe the development of a second-generation TF-targeting immunoconjugate (called L-ICON1, for lighter or light chain ICON) with improved efficacy and safety profiles compared with the original ICON. We showed that L-ICON1 kills TNBC cells in vitro via antibody-dependent cell-mediated cytotoxicity and can be used to treat human and murine TNBC CDX as well as PDX in vivo in orthotopic mouse models. Thus, TF could be a useful target for the development of immunotherapeutics for TNBC patients, with or without BRCA1 and BRCA2 mutations. Cancer Immunol Res; 6(6); 671–84. ©2018 AACR.
Biological Tools to Deal with Pollution : Selected Advances and Novel Perspectives
Authors: Ghanemi Abdelaziz , Boubertakh Besma 
Published: April 2018

Pollution represents a problem common to economy and public health. Indeed, the public health, because of the divers’ type of pollutions, is facing divers challenges for which urgent solutions are required.The biology provides approaches not only to deal with the pollution, but also to obtain economic benefits. Some living organisms have particular metabolisms that allow them to assimilate and metabolite the polluting agents and thus reduce the impact they have on both environment and public health. On the other hand, the metabolic properties of specific organisms make the polluting elements raw materials to synthesize other elements that are benefits for economy and non-toxic for the ecology and the biohealth. Yet, other options such as the regulations and laws are required to improve the efficiency of these approaches.
Reliability and Validaty of St George Respiratory Questionnaire (SGRQ) into Indonesian Version
Authors: Adnan Adnan , Perwitasari Dyah Aryani , Mulyani Ully Adhie 
Published: April 2018

Tuberculosis (TB) is one of the disease as the highest contributor to the disease burden in Indonesia. Tuberculosis can affect the patients’ quality of life, such as psychological, physical, and social functioning. St. George's Respiratory Questionnaire (SGRQ) is a special instrument which was widely used to measure the patients’ quality of life with respiratory disease. The objective of this study was to validate the Indonesian version of the SGRQ as instrument to collect data. A descriptive cross section design with 61 subjects was conducted at the Pulmonary Clinics and Primary Health Centers in the region of Yogyakarta within 3 months. The validation process included the known group validity, convergent and discriminant validity and factor analysis. There were 14 items question numbers which did not meet the criteria for convergent validity and 9 items which did not meet the criteria for discriminant validity. Known group validity analysis on gender showed that of the three domains of SGRQ, the activity domain gave statistically significant result. The factor analysis showed the result of Kaiser Meyer Olkin analysis (KMO) was less than 0.5. With a few modifications, the Indonesian version of SGRQ is valid and reliable for measuring quality of life in tuberculosis patients.
Meta-Analysis of the Relationship Between Ethnicity, Obesity, and Type 2 Diabetes of Adults in Urban Populations of Central America
Authors: Wuenstel William G , Johnson James A. , Humphries James , Samuel Cheryl 
Published: April 2018

<table width="593" border="1" cellspacing="0" cellpadding="0"><tbody><tr><td rowspan="2" valign="top" width="387">The purpose of this meta-analysis was to examine the impact of ethnicity and obesity as it relates to Type-2 Diabetes (T2D) in specific Central American countries. A meta-analysis was conducted to determine the association of ethnicity, obesity, and T2D. Four studies that qualified for inclusion were identified by searching MEDLINE and PubMed databases. The studies on the association of ethnicity and T2D had a combined population resulted in 265,858 study participants. Two studies on the association of obesity and T2D had 197,899 participants. An analysis of the data was conducted utilizing the relative risk ration, odds ratio, and forest plots. The comparison of the relative risk of T2D across ethnic categories by studies range for Blacks was 1.59 to 2.74, Asians was 1.43 to 2.08, and Hispanics .92 to 2.91. The ethnic difference in the prevalence of diabetes was almost two-fold higher in all ethnic groups than among the Caucasians with a significance level of 95%. A comparison of relative risk of T2D across weight categories was significantly higher among those with a diagnosed of diabetes in all reported areas. The odds ratio was very close to the risk ratio in both ethnicity and obesity to the development of T2D. The meta-analysis findings documented that an association does exist between ethnicity and obesity to the development of type 2 diabetes.</td><td width="0" height="85"> </td></tr><tr><td width="0" height="82"> </td></tr></tbody></table>
Incidence and Predictors of Tuberculosis among Adult PLWHA at Public Health Facilities of Hawassa City
Authors: Bekele Henok , Kote Mesfin , Yesuf Aman , Girum Tadele 
Published: April 2018

Tuberculosis (TB) is the most frequently diagnosed opportunistic infection (OI) and disease in people living with HIV/AIDS (PLWHA), world-wide. This study aimed at determining the incidence and predictors of tuberculosis among people living with HIV.A Six year retrospective follow up study was conducted among adult PLHIV. The Cox proportional hazards model was used to identify predictors.A total of 554 patients were followed and produced 1830.3 person year of observation. One hundred sixty one new TB cases occurred during the follow up period. The overall incidence density of TB was 8.79 per 100 person-year (PY). It was high (148.71/100 PY) in the first year of enrolment. The cumulative proportion of TB free survival was 79% and 67% at the end of first and sixth years, respectively. Not having formal education(AHR=2.68, 95%CI: 1.41, 5.11 ), base line WHO clinical stage IV (AHR = 3.22, 95% CI=1.91-5.41), CD4 count &lt;50 cell/ul (AHR=2.41, 95%CI=1.31, 4.42), Being bed redden (AHR= 2.89, 95%CI=1.72, 3.78), past TB history (AHR=1.65, 95% CI = 1.06,2.39), substance use (AHR=1.46, 95% CI=1.03,2.06) and being on pre ART (AHR=1.62, 95%CI:1.03-2.54 ) were independently predicted tuberculosis occurrence. Advanced WHO clinical stage, limited functional status, past TB history, addiction and low CD4 (&lt;50cell/ul) count at enrollment were found to be the independent predictor of tuberculosis occurrence. Therefore early initiation of treatment and intensive follow up is important.
Health Status Variation Across Practices in Outpatients With Heart Failure
Authors: Khariton Yevgeniy , Hernandez Adrian F. , Fonarow Gregg C. , Sharma Puza P. , Duffy Carol I. , Thomas Laine , Mi Xiaojuan , Albert Nancy M. , Butler Javed , McCague Kevin , Nassif Michael E. , Williams Fredonia B. , DeVore Adam , Patterson J. Herbert , Spertus John A. 
Published: April 2018

Background:
Although a key treatment goal for patients with heart failure with reduced ejection fraction is to optimize their health status (their symptoms, function, and quality of life), the variability across outpatient practices in achieving this goal is unknown.

Methods and Results:

In the CHAMP-HF (Change the Management of Patients With Heart Failure) registry, associations between baseline practice characteristics and Kansas City Cardiomyopathy Questionnaire (KCCQ) Overall Summary (OS) and Symptom Frequency (SF) scores were assessed in 3494 patients across 140 US practices using hierarchical regression after accounting for 23 patient and 11 treatment characteristics. We then calculated an adjusted median odds ratio to quantify the average difference in likelihood that a patient would have excellent (KCCQ-OS, ≥75) health status or minimal (monthly or fewer) symptoms (KCCQ-SF, ≥75) when treated at one practice versus another, at random. The mean (±SD) KCCQ-OS and KCCQ-SF were 64.2±24 and 68.9±25.6, with 40% (n=1380) and 50% (n=1760) having KCCQ scores ≥75, respectively. The adjusted median odds ratio across practices, for KCCQ-OS ≥75, was 1.70 (95% confidence interval, 1.54–1.99;
P
<0.001) indicating a median 70% higher odds of a patient having good-to-excellent health status when treated at one random practice versus another. In regard to KCCQ-SF, the adjusted median odds ratio for KCCQ-SF ≥75 was 1.54 (95% confidence interval, 1.41–1.76;
P
=0.001).

Conclusions:
In a large, contemporary registry of outpatients with chronic heart failure with reduced ejection fraction, we observed significant practice-level variability in patients’ health status. Quantifying patients’ health status as a measure of quality should be explored as a foundation for improving care.

Clinical Trial Registration:

URL:
https://www.centerwatch.com
. Unique identifier: TX144901.
Attended and Unattended Automated Office Blood Pressure Measurements Have Better Agreement With Ambulatory Monitoring Than Conventional Office Readings
Authors: Andreadis Emmanuel A. , Geladari Charalampia V. , Angelopoulos Epameinondas T. , Savva Florentia S. , Georgantoni Anna I. , Papademetriou Vasilios 
Published: April 2018

Background
Automated office blood pressure (AOBP) measurement is superior to conventional office blood pressure (OBP) because it eliminates the “white coat effect” and shows a strong association with ambulatory blood pressure.

Methods and Results
We conducted a cross‐sectional study in 146 participants with office hypertension, and we compared AOBP readings, taken with or without the presence of study personnel, before and after the conventional office readings to determine whether their variation in blood pressure showed a difference in blood pressure values. We also compared AOBP measurements with daytime ambulatory blood pressure monitoring and conventional office readings. The mean age of the studied population was 56±12 years, and 53.4% of participants were male. Bland–Altman analysis revealed a bias (ie, mean of the differences) of 0.6±6 mm Hg systolic for attended AOBP compared with unattended and 1.4±6 and 0.1±6 mm Hg bias for attended compared with unattended systolic AOBP when measurements were performed before and after conventional readings, respectively. A small bias was observed when unattended and attended systolic AOBP measurements were compared with daytime ambulatory blood pressure monitoring (1.3±13 and 0.6±13 mm Hg, respectively). Biases were higher for conventional OBP readings compared with unattended AOBP (−5.6±15 mm Hg for unattended AOBP and oscillometric OBP measured by a physician, −6.8±14 mm Hg for unattended AOBP and oscillometric OBP measured by a nurse, and −2.1±12 mm Hg for unattended AOBP and auscultatory OBP measured by a second physician).

Conclusions
Our findings showed that independent of the presence or absence of medical staff, AOBP readings revealed similar values that were closer to daytime ambulatory blood pressure monitoring than conventional office readings, further supporting the use of AOBP in the clinical setting.
Territorial fish distinguish familiar neighbours individually
Authors: Saeki Taiga , Sogawa Shumpei , Hotta Takashi , Kohda Masanori 
Published: April 2018

Abstract
True individual recognition (TIR), the ability to distinguish multiple familiar members individually, is more elaborate than class-level recognition, and evidence for the ability to perform TIR is reported from primates, some other social mammals, birds and lizard in vertebrates. These animals exhibit a highly social structure, wherein TIR is essential for their social interactions. Such high sociality has been documented in fish, but clear evidence of TIR has been limited. The cichlid, Neolamprologus pulcher, a cooperative breeder that guards a territory, exhibits the dear enemy relationship. Here, we show that this fish distinguishes two familiar neighbours individually, i.e., TIR ability, using one-way mirrors in experimental tanks. Focal fish established the dear enemy relationship with two neighbours, NA and NB, and displayed limited aggression towards these familiar neighbours. However, their aggressiveness towards neighbour NB increased when they were shifted from the original side of the tank after NA was removed, suggesting that they distinguished NB from NA or regarded NB as a stranger. Interestingly, this aggression level against the shifted neighbour NB largely decreased within 1 min. This decrease contrasted with the longer and more frequent aggressiveness towards unfamiliar strangers. These results suggest that focal fish recognised neighbour NB as a familiar stranger but probably punished NB that moved beyond its territory, that is, betrayed the dear enemy relationship. We prevented the effects of the behavioural reactions of exposed individuals using a one-way mirror. Thus, we conclude that this fish species displays TIR and discuss that TIR is prevalent in territorial animals in which the dear enemy effect is common.
Descent Rate Models of the Synchronization of the Quasi-Biennial Oscillation by the Annual Cycle in Tropical Upwelling
Authors: Rajendran Kylash , Moroz Irene M. , Osprey Scott M. , Read Peter L. 
Published: April 2018

Abstract
The response of the quasi-biennial oscillation (QBO) to an imposed mean upwelling with a periodic modulation is studied, by modeling the dynamics of the zero wind line at the equator using a class of equations known as descent rate models. These are simple mathematical models that capture the essence of QBO synchronization by focusing on the dynamics of the height of the zero wind line. A heuristic descent rate model for the zero wind line is described and is shown to capture many of the synchronization features seen in previous studies of the QBO. It is then demonstrated using a simple transformation that the standard Holton–Lindzen model of the QBO can itself be put into the form of a descent rate model if a quadratic velocity profile is assumed below the zero wind line. The resulting nonautonomous ordinary differential equation captures much of the synchronization behavior observed in the full Holton–Lindzen partial differential equation. The new class of models provides a novel framework within which to understand synchronization of the QBO, and we demonstrate a close relationship between these models and the circle map well known in the mathematics literature. Finally, we analyze reanalysis datasets to validate some of the predictions of our descent rate models and find statistically significant evidence for synchronization of the QBO that is consistent with model behavior.
Near-Global Covariability of Hourly Precipitation in Space and Time
Authors: Trenberth Kevin E. , Zhang Yongxin 
Published: April 2018

Abstract
A detailed analysis of hourly precipitation from 60°N to 60°S for the covariability is performed at 0.25° resolution using the new CMORPH dataset. For all points, correlations are computed with surrounding points both concurrently and for various leads and lags up to a day. Results are more coherent over the oceans than land; the contours of constant correlation tend to be elliptical, oriented northeast–southwest in the northern extratropics and southeast–northwest in the southern extratropics. An ellipse is fitted to the correlation pattern, and major and minor axis vectors and eccentricity are mapped. Based upon both the isotropic correlations and ellipse, points are allocated to one of 20 clusters, and 16 are documented. Over the main extratropical ocean storm tracks, correlations exceed 0.8 for points 50 km distant and fall to about 0.3 at about 5° radius. In the tropics values drop to 0.65 within 50 km and 0.2 at 5° radius. Over land, values are lower in summer and drop to 0.1 at 5° radius. Decorrelation e-folding distances range from less than 50 km over land to 200 km over extratropical ocean storm tracks. The movement of precipitation is compared with mean atmospheric winds. The lead–lag relationships indicate movement of systems but reveal the relatively short lifetimes of precipitation, of less than 12 h, even taking movement into account. The orientation of the ellipse reflects the structures of rain phenomena (fronts, etc.) rather than movement. These statistics demonstrate that daily averages fail to capture the essential character of precipitation.
Observations of the Tasman Sea Internal Tide Beam
Authors: Waterhouse Amy F. , Kelly Samuel M. , Zhao Zhongxiang , MacKinnon Jennifer A. , Nash Jonathan D. , Simmons Harper , Brahznikov Dmitry , Rainville Luc , Alford Matthew , Pinkel Rob 
Published: April 2018

AbstractLow-mode internal tides, a dominant part of the internal wave spectrum, carry energy over large distances, yet the ultimate fate of this energy is unknown. Internal tides in the Tasman Sea are generated at Macquarie Ridge, south of New Zealand, and propagate northwest as a focused beam before impinging on the Tasmanian continental slope. In situ observations from the Tasman Sea capture synoptic measurements of the incident semidiurnal mode-1 internal-tide, which has an observed wavelength of 183 km and surface displacement of approximately 1 cm. Plane-wave fits to in situ and altimetric estimates of surface displacement agree to within a measurement uncertainty of 0.3 cm, which is the same order of magnitude as the nonstationary (not phase locked) mode-1 tide observed over a 40-day mooring deployment. Stationary energy flux, estimated from a plane-wave fit to the in situ observations, is directed toward Tasmania with a magnitude of 3.4 ± 1.4 kW m−1, consistent with a satellite estimate of 3.9 ± 2.2 kW m−1. Approximately 90% of the time-mean energy flux is due to the stationary tide. However, nonstationary velocity and pressure, which are typically 1/4 the amplitude of the stationary components, sometimes lead to instantaneous energy fluxes that are double or half of the stationary energy flux, overwhelming any spring–neap variability. Despite strong winds and intermittent near-inertial currents, the parameterized turbulent-kinetic-energy dissipation rate is small (i.e., 10−10W kg−1) below the near surface and observations of mode-1 internal tide energy-flux convergence are indistinguishable from zero (i.e., the confidence intervals include zero), indicating little decay of the mode-1 internal tide within the Tasman Sea.
Impact of Enhanced Atmospheric Motion Vectors on HWRF Hurricane Analyses and Forecasts with Different Data Assimilation Configurations
Authors: Zhang Shixuan , Pu Zhaoxia , Velden Christopher 
Published: April 2018

Abstract
The impacts of enhanced satellite-derived atmospheric motion vectors (AMVs) on the numerical prediction of intensity changes during Hurricanes Gonzalo (2014) and Joaquin (2015) are examined. Enhanced AMVs benefit from special data-processing strategies and are examined for impact on model forecasts via assimilation experiments by employing the National Centers for Environmental Prediction (NCEP) operational Hurricane Weather Research and Forecasting (HWRF) Model using a Gridpoint Statistical Interpolation analysis system (GSI)-based ensemble–variational hybrid system. Two different data assimilation (DA) configurations, one with and one without the use of vortex initialization (VI), are compared. It is found that the assimilation of enhanced AMVs can improve the HWRF track and intensity forecasts of Gonzalo and Joaquin during their intensity change phases. The degree of data impact depends on the DA configuration used. Overall, assimilation of enhanced AMVs in the innermost domain (e.g., storm inner-core region and its immediate vicinity) outperforms other DA configurations, both with and without VI, as it results in better track and intensity forecasts. Compared to the experiment with VI, assimilation of enhanced AMVs without VI reveals more notable data impact on the forecasts of Hurricane Gonzalo, as the VI before DA alters the first guess and reduces the actual number of AMV observations assimilated into the DA system. Even with VI, assimilation of enhanced AMVs in the inner-core region can at least partially mitigate the negative effect of VI on the intensity forecast of Hurricane Gonzalo and alleviate the unrealistic vortex weakening in the simulation by removing unrealistic outflow structure and unfavorable thermodynamic conditions, thus leading to improved intensity forecasts.
Improving NCEP HWRF Simulations of Surface Wind and Inflow Angle in the Eyewall Area
Authors: Wang Weiguo , Sippel Jason A. , Abarca Sergio , Zhu Lin , Liu Bin , Zhang Zhan , Mehra Avichal , Tallapragada Vijay 
Published: April 2018

Abstract
This note describes a modification of the boundary layer parameterization scheme in the Hurricane Weather Research and Forecasting (HWRF) Model, which improves the simulations of low-level wind and surface inflow angle in the eyewall area and has been implemented in the HWRF system and used in the operational system since 2016. The modification is on an observation-based adjustment of eddy diffusivity previously implemented in the model. It is needed because the previous adjustment resulted in a discontinuity in the vertical distribution of eddy diffusivity near the surface-layer top, which increases the friction within the surface layer and compromises the surface-layer constant-flux assumption. The discontinuity affects the simulation of storm intensity and intensification, one of the main metrics of model performance, particularly in strong tropical cyclones. This issue is addressed by introducing a height-dependent adjustment so that the vertical profile of eddy diffusivity is continuous throughout the boundary layer. It is shown that the implementation of the modification results in low-level winds and surface inflow angles in the storm’s eyewall region closer to observations.