bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overlapping functions of Krüppel-like factor family members: targeting multiple transcription factors to maintain the naïve pluripotency of mouse embryonic stem cells
Authors: Yamane Mariko , Ohtsuka Satoshi , Matsuura Kumi , Nakamura Akira , Niwa Hitoshi 
Published: May 2018

ABSTRACT
Krüppel-like factors (Klfs) have a pivotal role in maintaining self-renewal of mouse embryonic stem cells (mESCs). The functions of three Klf family members (Klf2, Klf4 and Klf5) have been identified, and are suggested to largely overlap. For further dissection of their functions, we applied an inducible knockout system for these Klf family members and assessed the effects of combinatorial loss of function. As a result, we confirmed that any one of Klf2, Klf4 and Klf5 was sufficient to support self-renewal, whereas the removal of all three compromised it. The activity of any single transcription factor, except for a Klf family member, was not sufficient to restore self-renewal of triple-knockout mESCs. However, some particular combinations of transcription factors were capable of the restoration. The triple-knockout mESCs were successfully captured at primed state. These data indicate that the pivotal function of a Klf family member is transduced into the activation of multiple transcription factors in a naïve-state-specific manner.
NvERTx: a gene expression database to compare embryogenesis and regeneration in the sea anemone Nematostella vectensis
Authors: Warner Jacob F. , Guerlais Vincent , Amiel Aldine R. , Johnston Hereroa , Nedoncelle Karine , Röttinger Eric 
Published: May 2018

ABSTRACT
For over a century, researchers have been comparing embryogenesis and regeneration hoping that lessons learned from embryonic development will unlock hidden regenerative potential. This problem has historically been a difficult one to investigate because the best regenerative model systems are poor embryonic models and vice versa. Recently, however, there has been renewed interest in this question, as emerging models have allowed researchers to investigate these processes in the same organism. This interest has been further fueled by the advent of high-throughput transcriptomic analyses that provide virtual mountains of data. Here, we present Nematostella vectensis Embryogenesis and Regeneration Transcriptomics (NvERTx), a platform for comparing gene expression during embryogenesis and regeneration. NvERTx consists of close to 50 transcriptomic data sets spanning embryogenesis and regeneration in Nematostella. These data were used to perform a robust de novo transcriptome assembly, with which users can search, conduct BLAST analyses, and plot the expression of multiple genes during these two developmental processes. The site is also home to the results of gene clustering analyses, to further mine the data and identify groups of co-expressed genes. The site can be accessed at http://nvertx.kahikai.org.
Obituary: John Sulston (1942-2018)
Authors: White John 
Published: May 2018

Abstract
John Sulston, a pioneer in the developmental studies of the nematode C. elegans who went on to spearhead the sequencing of the genome of this organism and ultimately the human genome, died on 6th March 2018, shortly after being diagnosed with stomach cancer. Here, I reflect on John's life and work, with a particular focus on his time working on the developmental genetics and lineage of C. elegans.
Variation in hearing within a wild population of beluga whales (Delphinapterus leucas)
Authors: Mooney T. Aran , Castellote Manuel , Quakenbush Lori , Hobbs Roderick , Gaglione Eric , Goertz Caroline 
Published: May 2018

ABSTRACTDocumenting hearing abilities is vital to understanding a species’ acoustic ecology and for predicting the impacts of increasing anthropogenic noise. Cetaceans use sound for essential biological functions such as foraging, navigation and communication; hearing is considered to be their primary sensory modality. Yet, we know little regarding the hearing of most, if not all, cetacean populations, which limits our understanding of their sensory ecology, population level variability and the potential impacts of increasing anthropogenic noise. We obtained audiograms (5.6–150 kHz) of 26 wild beluga whales to measure hearing thresholds during capture–release events in Bristol Bay, AK, USA, using auditory evoked potential methods. The goal was to establish the baseline population audiogram, incidences of hearing loss and general variability in wild beluga whales. In general, belugas showed sensitive hearing with low thresholds (&lt;80 dB) from 16 to 100 kHz, and most individuals (76%) responded to at least 120 kHz. Despite belugas often showing sensitive hearing, thresholds were usually above or approached the low ambient noise levels measured in the area, suggesting that a quiet environment may be associated with hearing sensitivity and that hearing thresholds in the most sensitive animals may have been masked. Although this is just one wild population, the success of the method suggests that it should be applied to other populations and species to better assess potential differences. Bristol Bay beluga audiograms showed substantial (30–70 dB) variation among individuals; this variation increased at higher frequencies. Differences among individual belugas reflect that testing multiple individuals of a population is necessary to best describe maximum sensitivity and population variance. The results of this study quadruple the number of individual beluga whales for which audiograms have been conducted and provide the first auditory data for a population of healthy wild odontocetes.
The systematic approach to improving care for Frail Older Patients (SAFE) study: A protocol for co-designing a frail older person’s pathway
Authors: Ní Shé Éidín , McCarthy Mary , O'Donnell Deirdre , Collins Orla , Hughes Graham , Salter Nigel , Cogan Lisa , O'Donoghue Coailfhionn , McGrath Emmet , O'Donovan John , Patton Andrew , McAuliffe Eilish , O'Shea Diarmuid , Cooney Marie Therese 
Published: May 2018

Background: Frailty is the age-accelerated decline across multiple organ systems which leads to vulnerability to poor resolution of homeostasis after a stressor event. This loss of reserve means that a minor illness can result in a disproportionate loss of functional ability. Improving acute care for frail older patients is now a national priority and an important aspect of the National Programme for Older People in Ireland. Evidence suggests that an interdisciplinary approach incorporating rapid comprehensive geriatric assessment and early intervention by an interdisciplinary team can reduces susceptibility to hospitalisation related functional decline. The aim of the Systematic Approach to Improving Care for Frail Older Patients (SAFE) is to develop and explore the process of implementing a model of excellence in the delivery of patient-centred integrated care within the context of frail older people’s acute admissions. Methods: The SAFE study will employ a mixed methodology approach, including a rapid realist review of the current literature alongside a review of baseline data for older people attending the emergency department. Semi-structured interviews will be undertaken to document the current pathway. The intervention processes and outcomes will be jointly co-designed by a patient and public involvement (PPI) group together with the interdisciplinary healthcare professionals from hospital, community and rehabilitation settings. Successive rounds of Plan-Do-Study-Act cycles will then be undertaken to test and refine the pathway for full implementation. Discussion: This research project will result in a plan for implementing an integrated, patient-centred pathway for acute care of the frail older people which has been tested in the Irish setting. During the process of development, each element of the new pathway will be tested in turn to ensure that patient centred outcomes are being realised. This will ensure the resulting model of care is ready for implementation in the context of the Irish health service.
Product Life Cycle Data Set: Raw and Cleaned Data of Weekly Orders for Personal Computers
Authors: Acimovic Jason , Erize Francisco , Hu Kejia , Thomas Douglas J. , Mieghem Jan A. Van 
Published: May 2018

We provide and describe a data set of N = 8,935 weekly, normalized customer orders over the entire product life cycle for 170 Dell computer products sold in North America over a three and a half year period, from 2013–2016. Total orders for these products exceeded four million units and well over one billion dollars in revenue. While Dell is historically known for fulfilling customer demand with a build-to-order approach, the products in this data set were designated as build-to-stock products. There are three elements in the data that, depending on the research application, researchers may want to identify or mitigate. First, some products have seemingly anomalous orders representing one-time purchases from large customers. Second, there are negative values for some products representing order cancellations. Third, end-of-life sales may be significantly influenced by management action. We present approaches for cleaning the data to address these issues.The supplemental material is available at https://doi.org/10.1287/msom.2017.0692 .
Predicting and preventing alcohol relapse in alcohol-related liver disease
Authors: Ranasinghe Iyoni , Sin Jacqueline , Norman Ian , Lau-Walker Margaret 
Published: May 2018

Background: despite a 450% increase in UK alcohol-related liver disease mortality over the past 30 years, little evidence-based guidance exists regarding preventing recidivism post-liver transplant for alcohol-related liver disease. Method: a systematic literature review was conducted to identify demographic variables predictive of alcohol relapse and effective psychosocial interventions for alcohol-related liver disease patients post-liver transplant. Results: variables most significantly predictive of alcohol relapse post-transplant were—less than 12 months pre-liver transplant abstinence; patients with children; poor pre-liver transplant psychosomatic evaluation; non-compliance with post-liver transplant treatment plan; and patients with active insurance policies. Structured management was the most effective psychosocial intervention in preventing alcohol relapse. Conclusion: findings should be interpreted cautiously, due to limited and poor-quality evidence. Rigorously designed further research of the psychosocial interventions targeting predictive demographic variables is recommended.
„Gleichmacherei“ ausdrücklich erwünscht!
Authors: Lison Barbara 
Published: May 2018

Zusammenfassung
Gender-Mainstreaming hat als wichtiges gesellschaftspolitisches Ziel im Kontext des Diversity-Management auch Einzug in die strategischen Handlungsfelder und auch in die operative Arbeit der Stadtbibliothek Bremen gefunden. Die diesbezügliche Konzeption der Stadtbibliothek geht von einer der grundlegenden Prämissen des Gender-Mainstreaming aus, die besagt, dass es keine geschlechtsneutrale Realität gibt. Daher müssten bei allen gesellschaftlichen Vorhaben und Entscheidungen die unterschiedlichen Lebenssituationen sowie Interessen von Männern und Frauen konsequent berücksichtigt werden.
Hamburgs Weg zu einer Open-Access-Strategie
Authors: Meinecke Isabella 
Published: May 2018

Zusammenfassung
In der Hansestadt Hamburg startete 2014/2015 der Senat eine breit angelegte Initiative zur Digitalisierung. Diese betraf auch Kultur, Forschung und Lehre. Zeitnah setzten Aktivitäten ein, die eine übergreifende Open-Access-Strategie zum Ziel hatten. In einem offenen und transparenten Prozess entwickelten Behörde, Hochschulen und die Staats- und Universitätsbibliothek Hamburg eine übergreifende Open-Access-Strategie, deren Umsetzung im Frühjahr 2018 einsetzte. Die Gegebenheiten des Wissenschaftsstandorts, die Diversität der Institutionen wie auch behördliche Rahmenbedingungen waren dabei Herausforderungen, die es zu meistern galt.
Finding variants for construction-based dialectometry: A corpus-based approach to regional CxGs
Authors: Dunn Jonathan 
Published: May 2018

AbstractThis paper develops a construction-based dialectometry capable of identifying previously unknown constructions and measuring the degree to which a given construction is subject to regional variation. The central idea is to learn a grammar of constructions (a CxG) using construction grammar induction and then to use these constructions as features for dialectometry. This offers a method for measuring the aggregate similarity between regional CxGs without limiting in advance the set of constructions subject to variation. The learned CxG is evaluated on how well it describes held-out test corpora while dialectometry is evaluated on how well it can model regional varieties of English. The method is tested using two distinct datasets: First, the International Corpus of English representing eight outer circle varieties; Second, a web-crawled corpus representing five inner circle varieties. Results show that the method (1) produces a grammar with stable quality across sub-sets of a single corpus that is (2) capable of distinguishing between regional varieties of English with a high degree of accuracy, thus (3) supporting dialectometric methods for measuring the similarity between varieties of English and (4) measuring the degree to which each construction is subject to regional variation. This is important for cognitive sociolinguistics because it operationalizes the idea that competition between constructions is organized at the functional level so that dialectometry needs to represent as much of the available functional space as possible.
Archilochus 222W and 39W: Allusion and Reception, Hesiod and Catullus
Authors: Hawkins Shane 
Published: May 2018

AbstractThis article is a contribution to our understanding of how Archilochean poetics may be situated in the longer poetic tradition. In examining two fragments that have received little attention, I hope to illustrate how Archilochus’ poetry both engaged with its predecessors and was in turn engaged by its successors. Fragment 222W employs a theme that was perhaps already conventional for Hesiod, in which the incompatibility of the sexes is implicated in the cycle of seasons, an idea that also seems relevant to Archilochus’ quarrel with the daughters of Lycambes. Light is shed on 39W by comparing it to later words for skinning that serve as metaphors for cheating someone, the best known example of which is found in Catullus. In the first fragment the text can be elucidated by a look to Archilochus’ forerunners, and in the second by looking to his heirs.
Deterrence Then and Now.
Authors: Thomson James A. 
Published: May 2018

Abstract:
Against the backdrop of an international system becoming more confrontational in nature, the subject of deterrence is back again. This article provides an overview of the nature of the deterrence problem during the Cold War period and today. While the broader circumstances have changed markedly, today, the central issue of deterrence remains the same as in the Cold War: how to maintain the credibility of the American threat to employ nuclear weapons in the defense of allies in the face of adversaries that can retaliate with devastating nuclear attacks against the US itself. There is little doubt about the threat of the US or other nuclear powers to retaliate in the event of a nuclear attack against their own homelands, so long as those retaliatory forces can survive the initial attack. The problem is the credibility of US extended deterrence.
Programmed cell death-1 and programmed cell death ligand-1 antibodies-induced dysthyroidism
Authors: Jaafar Jaafar , Fernandez Eugenio , Alwan Heba , Philippe Jacques 
Published: May 2018

Background
Monoclonal antibodies blocking the programmed cell death-1 (PD-1) or its ligand (PD-L1) are a group of immune checkpoints inhibitors (ICIs) with proven antitumor efficacy. However, their use is complicated by immune-related adverse events (irAEs), including endocrine adverse events (eAEs).

Purpose
We review the incidence, time to onset and resolution rate of dysthyroidism induced by PD-1/PD-L1 Ab, and the clinical, biological and radiological findings. We aim to discuss the potential mechanisms of PD-1/PD-L1 Ab-induced dysthyroidism, and to propose a management algorithm.

Methods
We performed a literature search of available clinical trials regarding PD-1/PD-L1 Ab in the PubMed database. We selected all English language clinical trials that included at least 100 patients. We also present selected case series or reports, retrospective studies and reviews related to this issue.

Findings
In patients treated with PD-1 Ab, hypothyroidism occurred in 2–10.1% and hyperthyroidism occurred in 0.9–7.8%. When thyroiditis was reported separately, it occurred in 0.34–2.6%. Higher rates were reported when PD-1 Ab were associated with other ICI or chemotherapy. The median time to onset of hyperthyroidism and hypothyroidism after PD-1 Ab initiation was 23–45 days and 2–3.5 months, respectively. Regarding PD-L1 Ab, hypothyroidism occurred in 0–10% and hyperthyroidism in 0.5–2% of treated patients. The average time to onset of dysthyroidism after PD-L1 Ab was variable and ranged from 1 day after treatment initiation to 31 months.

Conclusion
Dysthyroidism occurs in up to 10% of patients treated with PD-1/PD-L1 Ab. Hypothyroidism and reversible destructive thyroiditis are the most frequent endocrine adverse events (eAE) in PD-1/PD-L1 treated patients. Immune and non-immune mechanisms are potentially involved, independently of the presence of thyroid antibodies.
Spermiogenesis and Male Fertility Require the Function of Suppressor of Hairy-Wing in Somatic Cyst Cells ofDrosophila
Authors: Duan Tingting , Geyer Pamela K 
Published: May 2018

AbstractDrosophila Suppressor of Hairy-wing [Su(Hw)] is a multivalent transcription factor. Although best known for its gypsy retrotransposon insulator function, its functions at non-gypsy genomic binding sites are poorly understood...Drosophila Suppressor of Hairy-wing [Su(Hw)] protein is an example of a multivalent transcription factor. Although best known for its role in establishing the chromatin insulator of the gypsy retrotransposon, Su(Hw) functions as an activator and repressor at non-gypsy genomic sites. It remains unclear how the different regulatory activities of Su(Hw) are utilized during development. Motivated from observations of spatially restricted expression of Su(Hw) in the testis, we investigated the role of Su(Hw) in spermatogenesis to advance an understanding of its developmental contributions as an insulator, repressor, and activator protein. We discovered that Su(Hw) is required for sustained male fertility. Although dynamics of Su(Hw) expression coincide with changes in nuclear architecture and activation of coregulated testis-specific gene clusters, we show that loss of Su(Hw) does not disrupt meiotic chromosome pairing or transcription of testis-specific genes, suggesting that Su(Hw) has minor architectural or insulator functions in the testis. Instead, Su(Hw) has a prominent role as a repressor of neuronal genes, consistent with suggestions that Su(Hw) is a functional homolog of mammalian REST, a repressor of neuronal genes in non-neuronal tissues. We show that Su(Hw) regulates transcription in both germline and somatic cells. Surprisingly, the essential spermatogenesis function of Su(Hw) resides in somatic cyst cells, implying context-specific consequences due to loss of this transcription factor. Together, our studies highlight that Su(Hw) has a major developmental function as a transcriptional repressor, with the effect of its loss dependent upon the cell-specific factors.
The Influence of Training, Leadership and Competency to Employee Performance with Employee Morale as Moderation Variables (Study on Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kota Denpasar)
Authors: Trisnawati Kadek Ayu , Mareni Putu Kepra , Sudja I Nengah 
Published: May 2018

This study aims to test and explain empirically the influence of training, leadership, and competence on employee performance at Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kota Denpasar. In addition, this study will also examine and explain the role of moderation of morale on the impact of training, leadership, and competence on employee performance.
This research is an explanative research that explains the influence of variables studied by cross-sectional. Quantitative approach is used as the main method of analysis to explain the results of research with data collection methods using questionnaires. The population in this study is all civil servants working at Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kota Denpasar, amounting to 140 people (not including Head of Service). While the sample research employed as many as 83 employees using the method of purposive sampling. All distributed questionnaires are feasible (valid and reliable) to be analyzed using Partial Least Square (PLS) with SmartPLS 3.0 software.
The results showed that the training followed by employees does not necessarily directly affect the performance of employees Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kota Denpasar. Another case of leadership and competence are able to predict positively the performance of employees. Information from other research results, morale is able to moderate positively on the effect of training on employee performance at Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kota Denpasar. These results provide meaning that employee morale perceived by Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kota Denpasar in the implementation of the work was able to strengthen the implementation of training activities that will be able to improve the performance of the work. Nevertheless, the spirit of work is not able to moderate on the influence of leadership and competence on the performance of employees at Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kota Denpasar. However, leadership and competence are positive predictors of employee performance.
Determinant Analysis of Job Satisfaction and Its Efect on Employee Performance at Pt. Bank Mandiri (Persero) Tbk.
Authors: Septiadi Pande Putu Surya , Suardhika dan I Nengah , Yuesti Anik 
Published: May 2018

This study aims to improve and optimize leadership and communication on job satisfaction, as well as its effect on employee performance. This research was conducted at Micro Banking Cluster Denpasar PT. Bank Mandiri (Persero) Tbk with a sample of all micro employee sales credit that work on the Micro Banking Cluster Denpasar PT. Bank Mandiri (Persero) Tbk, as many as 77 people. All data obtained from the questionnaire distribution is feasible to use, then analyzed using the model being developed with Partial Least Square (PLS).
The result of the research shows that (1) leadership has positive and significant effect on job satisfaction, (2) communication has positive and significant effect to job satisfaction, (3) leadership has positive and significant effect to employee's performance, (4) communication has positive and significant influence to employee’s performance, (5) job satisfaction has a positive and significant effect on employee's performance, (6) leadership has positive and significant effect on employee performance through job satisfaction and (7) communication has positive and significant influence to employee performance through job satisfaction.
The implication of this research is that leadership can be improved by paying attention to the influence to increase employee performance, the communication that has been running well, job satisfaction can be improved by paying attention to the supervision of superiors to improve employee performance and employee performance can be improved by paying attention to the quality of work.