bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized, blinded, prospective clinical trial of postoperative rehabilitation in dogs after surgical decompression of acute thoracolumbar intervertebral disc herniation
Authors: Zidan Natalia , Sims Cory , Fenn Joe , Williams Kim , Griffith Emily , Early Peter J. , Mariani Chris L. , Munana Karen R. , Guevar Julien , Olby Natasha J. 
Published: April 2018

BackgroundExperimental evidence shows benefit of rehabilitation after spinal cord injury (SCI) but there are limited objective data on the effect of rehabilitation on recovery of dogs after surgery for acute thoracolumbar intervertebral disc herniations (TL‐IVDH).ObjectiveCompare the effect of basic and intensive post‐operative rehabilitation programs on recovery of locomotion in dogs with acute TL‐IVDH in a randomized, blinded, prospective clinical trial.AnimalsThirty non‐ambulatory paraparetic or paraplegic (with pain perception) dogs after decompressive surgery for TL‐IVDH.MethodsBlinded, prospective clinical trial. Dogs were randomized (1:1) to a basic or intensive 14‐day in‐house rehabilitation protocol. Fourteen‐day open field gait score (OFS) and coordination (regulatory index, RI) were primary outcomes. Secondary measures of gait, post‐operative pain, and weight were compared at 14 and 42 days.ResultsOf 50 dogs assessed, 32 met inclusion criteria and 30 completed the protocol. There were no adverse events associated with rehabilitation. Median time to walking was 7.5 (2 – 37) days. Mean change in OFS by day 14 was 6.13 (confidence intervals: 4.88, 7.39, basic) versus 5.73 (4.94, 6.53, intensive) representing a treatment effect of −0.4 (−1.82, 1.02) which was not significant, P=.57. RI on day 14 was 55.13 (36.88, 73.38, basic) versus 51.65 (30.98, 72.33, intensive), a non‐significant treatment effect of −3.47 (−29.81, 22.87), P = .79. There were no differences in secondary outcomes between groups.ConclusionsEarly postoperative rehabilitation after surgery for TL‐IVDH is safe but doesn't improve rate or level of recovery in dogs with incomplete SCI.
Large sensitivity in land carbon storage due to geographical and temporal variation in the thermal response of photosynthetic capacity
Authors: Mercado Lina M. , Medlyn Belinda E. , Huntingford Chris , Oliver Rebecca J. , Clark Douglas B. , Sitch Stephen , Zelazowski Przemyslaw , Kattge Jens , Harper Anna B. , Cox Peter M. 
Published: April 2018

Summary

Plant temperature responses vary geographically, reflecting thermally contrasting habitats and long‐term species adaptations to their climate of origin. Plants also can acclimate to fast temporal changes in temperature regime to mitigate stress. Although plant photosynthetic responses are known to acclimate to temperature, many global models used to predict future vegetation and climate–carbon interactions do not include this process.

We quantify the global and regional impacts of biogeographical variability and thermal acclimation of temperature response of photosynthetic capacity on the terrestrial carbon (C) cycle between 1860 and 2100 within a coupled climate–carbon cycle model, that emulates 22 global climate models.

Results indicate that inclusion of biogeographical variation in photosynthetic temperature response is most important for present‐day and future C uptake, with increasing importance of thermal acclimation under future warming. Accounting for both effects narrows the range of predictions of the simulated global land C storage in 2100 across climate projections (29% and 43% globally and in the tropics, respectively).

Contrary to earlier studies, our results suggest that thermal acclimation of photosynthetic capacity makes tropical and temperate C less vulnerable to warming, but reduces the warming‐induced C uptake in the boreal region under elevated CO2.
Evolutionary history of HOMEODOMAIN LEUCINE ZIPPER transcription factors during plant transition to land
Authors: Romani Facundo , Reinheimer Renata , Florent Stevie N. , Bowman John L. , Moreno Javier E. 
Published: April 2018

Summary

Plant transition to land required several regulatory adaptations. The mechanisms behind these changes remain unknown. Since the evolution of transcription factors (TFs) families accompanied this transition, we studied the HOMEODOMAIN LEUCINE ZIPPER (HDZ) TF family known to control key developmental and environmental responses.

We performed a phylogenetic and bioinformatics analysis of HDZ genes using transcriptomic and genomic datasets from a wide range of Viridiplantae species.

We found evidence for the existence of HDZ genes in chlorophytes and early‐divergent charophytes identifying several HDZ members belonging to the four known classes (I–IV). Furthermore, we inferred a progressive incorporation of auxiliary motifs. Interestingly, most of the structural features were already present in ancient lineages. Our phylogenetic analysis inferred that the origin of classes I, III, and IV is monophyletic in land plants in respect to charophytes. However, class IIHDZ genes have two conserved lineages in charophytes and mosses that differ in the CPSCE motif.

Our results indicate that the HDZ family was already present in green algae. Later, the HDZ family expanded accompanying critical plant traits. Once on land, the HDZ family experienced multiple duplication events that promoted fundamental neo‐ and subfunctionalizations for terrestrial life.
Postoperative pain management in children: Guidance from the pain committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative)
Authors: Vittinghoff Maria , Lönnqvist Per‐Arne , Mossetti Valeria , Heschl Stefan , Simic Dusica , Colovic Vesna , Dmytriiev Dmytro , Hölzle Martin , Zielinska Marzena , Kubica‐Cielinska Anna , Lorraine‐Lichtenstein Elizabeth , Budić Ivana , Karisik Marijana , Maria Belen De Josè , Smedile Francesco , Morton Neil S. 
Published: April 2018

SummaryThe main remit of the European Society for Paediatric Anaesthesiology (ESPA) Pain Committee is to improve the quality of pain management in children. The ESPA Pain Management Ladder is a clinical practice advisory based upon expert consensus to help to ensure a basic standard of perioperative pain management for all children. Further steps are suggested to improve pain management once a basic standard has been achieved. The guidance is grouped by the type of surgical procedure and layered to suggest basic, intermediate, and advanced pain management methods. The committee members are aware that there are marked differences in financial and personal resources in different institutions and countries and also considerable variations in the availability of analgesic drugs across Europe. We recommend that the guidance should be used as a framework to guide best practice.
Apocrine hidrocystoma on the genitalia of a 9‐year‐old girl
Authors: Matsuyama Takashi , Yahagi Eiichiro , Mabuchi Tomotaka 
Published: April 2018

AbstractApocrine hidrocystomas are mostly found on the cheeks and eyelids but also on the scalp and neck. The age distribution is from 30 to 70 years old. We report a case of an apocrine hidrocystoma on the genitalia of a 9‐year‐old girl.
A case of extensive acquired progressive lymphangioma
Authors: Larkin Sydney C. , Wentworth Ashley B. , Lehman Julia S. , Tollefson Megha M. 
Published: April 2018

AbstractAcquired progressive lymphangioma (benign lymphangioendothelioma) is a rare lymphatic anomaly of unclear pathogenesis. Excision is generally advised for local disease, although other therapies have been tried. This report describes a unique case of extensive acquired progressive lymphangioma involving the abdomen, genitalia, and lower extremity of a 1‐year‐old boy. Rapid progression and multisite involvement required exploration of nonsurgical options for management.
Chromhidrosis due to exogenous oxidizing heavy metals: Clinical and laboratory findings
Authors: Erdol Sahin , Karakaya Sabahattin , Saglam Halil , Tarim Omer 
Published: April 2018

AbstractBackground/ObjectivesChromhidrosis is a rare condition of which there are only a few case reports in the literature. The aim of this study was to evaluate clinical, laboratory, and possible environmental factors in 13 patients with chromhidrosis to elucidate causative agents.MethodsData were obtained from the medical records of 13 patients with colored sweating between October 2015 and November 2016 (7 infants <1 year of age, 5 adults, 1 adolescent).ResultsPhysical examination was normal in all patients. Nine of 12 had high calculated serum free copper (75%). Urine glutamine was measured in 13 patients and was high in 11 (84.6%). Ten patients drank natural mineral water from Uludag Mountain, and two were exposed to an intrauterine device containing copper. One patient (8%) was not exposed to Uludag Mountain natural water or an intrauterine device.ConclusionWe propose that chronic exposure to water or devices that contain high amounts of heavy metal and ammonium may contribute to CH.
Idiopathic facial aseptic granuloma—A diagnostic challenge in pediatric dermatology
Authors: Borok Jenna , Holmes Ralph , Dohil Magdalene 
Published: April 2018

AbstractIdiopathic facial aseptic granuloma is a distinct, benign lesion that presents in very young children and is characterized by a painless facial nodule that usually appears on the cheek. It is typically characterized by a prolonged course but heals spontaneously or in response to antibiotic treatment. The challenge is to diagnose this entity correctly, ideally based on clinical acumen, to avoid surgical intervention with facial sutures and the resultant scarring and unnecessary treatment interventions. In this article, we discuss three cases of idiopathic facial aseptic granuloma to raise awareness and highlight the diagnostic challenges and possible link to childhood rosacea.
Characteristics of deposits and pump exchange in the Berlin Heart EXCOR ventricular assist device: Experience with 67 cases
Authors: Maeda Katsuhide , Almond Christopher , Hollander Seth A. , Rosenthal David N. , Kaufman Beth , Gowen Maryalice M. , Murray Jenna , Shuttleworth Paul , Reinhartz Olaf 
Published: April 2018

AbstractPump exchanges are frequently required in the Berlin Heart EXCOR VAD. We intended to describe the characteristics of pump deposits in a larger patient series and evaluate if changes in our exchange procedure over time have led to increased complications. We reviewed all EXCOR pump exchanges in our institution from July 2004 to October 2014. We gathered data on size and location of pump deposits and exchange procedures. EXCOR devices were implanted in 38 children. Support was LVAD only in 22, BiVAD in 13, and SVAD in 3 cases. Sixty‐seven pumps were exchanged. The incidence of pump exchanges per month was higher for smaller pumps and for RVADs vs LVADs. Indications were visible pump deposit in 55, stroke without visible deposit in 5, incorporation of membrane oxygenator in 3, pump size change in 2, and sepsis in 1 case, respectively. Deposits were located in the outflow valve in 73%, inflow valve in 22%, pump body in 3%, and outflow cannula in 3%. EXCOR pumps are predominantly exchanged for deposits, which are most frequently located in the outflow valves. The procedure is now carried out without sedation at the bedside. No major complications were observed during exchanges.
Successful treatment of chronic norovirus gastroenteritis with nitazoxanide in a pediatric kidney transplant recipient
Authors: Haubrich Kathryn , Gantt Soren , Blydt‐Hansen Tom 
Published: April 2018

AbstractUncontrolled studies suggest a benefit of nitazoxanide for the treatment of norovirus gastroenteritis in immunocompromised individuals. Here, we report the use of nitazoxanide in a 13‐year‐old male kidney transplant recipient who developed intractable norovirus gastroenteritis. Reduction of immunosuppression was not possible due to refractory TCMR. Administration of oral immunoglobulin and switching from tacrolimus to sirolimus failed to produce a meaningful clinical response. Treatment with a 14‐day course of nitazoxanide resulted in prompt resolution of diarrhea as well as clearance of norovirus from the stool despite intense immunosuppression. Nitazoxanide may be considered as an option for the treatment of intractable norovirus gastroenteritis in pediatric transplant patients when reduced immunosuppression is not feasible or other treatment options have failed. Further studies to evaluate the safety and effectiveness of nitazoxanide in immunocompromised children are needed.
Uncertain liability and stagnating CCS deployment in the European Union: Is it the Member States’ turn?
Authors: Weber Viktor 
Published: April 2018

AbstractEven though the European Union (EU) decided to promote carbon capture and storage (CCS) and it enacted a directive eight years ago to speed up the safe deployment of this technology, there is no functioning project yet in the EU. While this is a well‐understood technology with an important emission reduction potential, it requires a legal regime which affords sufficient certainty to operators about their potential liabilities. However, the European legal framework is perceived as achieving the opposite effect. The operator's liability is uncertain both in temporal and financial terms. This article considers that after the 2015 review of the CCS Directive, it is clear that at least a part in overcoming the industry's difficulties is more Member State action in the form of pragmatic interpretation and tailor‐made agreements, as it is the case in the ROAD project. Subsequently, certain technical and financial issues related to European CCS are analysed with a view to facilitate its deployment.
Projecting the Arena of Inclusion: The Case of South Korea in Pursuing a Phased Inclusive Growth Process
Authors: Wong Chan‐Yuan , Lee Keun 
Published: April 2018

AbstractSouth Korea created a mechanism that fuels inclusive growth, a process that coevolves economic growth and social well‐being. This study attempts to elaborate on the context and preconditions for development that would manifest salience policy implications for moving up the industrial value chain and attain inclusive growth. We contend against the view of simplified growth cum equity that is used to elucidate the success of Korea's socioeconomic development (economic miracles). Our findings informed us that there were intense measures taken throughout different phases of Korea's industrial development. In addition, we observed in many occasions intense negotiations between the state, firms, and civil society for social welfare and a better working environment. This led to a pursuit for inclusive growth in the post catching‐up phase that blended together many inclusive agendas, realizing growth that coevolved industrial upgrading and social welfare. This article seeks to explain how Korea populated its arena of inclusion in the process of pursuing rapid industrialization. The overview of different phases of development provides normative principles that are useful as a guide for other economies which aspire to attain similar development.
Agenda‐Setting at the Energy‐Water Nexus: Constructing and Maintaining a Policy Monopoly in U.S. Hydraulic Fracturing Regulation
Authors: Baka Jennifer , Neville Kate J. , Weinthal Erika , Bakker Karen 
Published: April 2018

AbstractDespite calls to increase federal oversight of hydraulic fracturing (HF), the U.S. Congress has maintained a regulatory system in which environmental regulatory authority is devolved to the states. We argue that this system is characterized by a long‐standing “policy monopoly”: a form of stability in policy agenda‐setting in which a specific manner of framing and regulating a policy issue becomes hegemonic. Integrating theories on agenda‐setting and environmental discourse analysis, we develop a nuanced conceptualization of policy monopoly that emphasizes the significance of regulatory history, public perceptions, industry–government relations, and environmental “storylines.” We evaluate how a policy monopoly in U.S. HF regulation has been constructed and maintained through a historical analysis of oil and gas regulation and a discourse analysis of eleven select congressional energy committee hearings. This research extends scholarship on agenda‐setting by better illuminating the importance of political economic and geographic factors shaping regulatory agendas and outcomes.
Maximising platelet availability by delaying cold storage
Authors: Wood B. , Johnson L. , Hyland R. A. , Marks D. C. 
Published: April 2018

Background and ObjectivesCold‐stored platelets may be an alternative to conventional room temperature (RT) storage. However, cold‐stored platelets are cleared more rapidly from circulation, reducing their suitability for prophylactic transfusion. To minimise wastage, it may be beneficial to store platelets conventionally until near expiry (4 days) for prophylactic use, transferring them to refrigerated storage to facilitate an extended shelf life, reserving the platelets for the treatment of acute bleeding.Materials and MethodsTwo ABO‐matched buffy‐coat‐derived platelets (30% plasma/70% SSP+) were pooled and split to produce matched pairs (n = 8 pairs). One unit was stored at 2‐6°C without agitation (day 1 postcollection; cold); the second unit was stored at 20‐24°C with constant agitation until day 4 then stored at 2–6°C thereafter (delayed‐cold). All units were tested for in vitro quality periodically over 21 days.ResultsDuring storage, cold and delayed‐cold platelets maintained a similar platelet count. While pH and HSR were significantly higher in delayed‐cold platelets, other metabolic markers, including lactate production and glucose consumption, did not differ significantly. Furthermore, surface expression of phosphatidylserine and CD62P, release of soluble CD62P and microparticles were not significantly different, suggesting similar activation profiles. Aggregation responses of delayed‐cold platelets followed the same trend as cold platelets once transferred to cold storage, gradually declining over the storage period.ConclusionThe metabolic and activation profile of delayed‐cold platelets was similar to cold‐stored platelets. These data suggest that transferring platelets to refrigerated storage when near expiry may be a viable option for maximising platelet inventories.
On the approximation of the concentration parameter for von Mises distribution
Authors: Moslim Nor Hafizah , Zubairi Yong Zulina , Hussin Abdul Ghapor , Hassan Siti Fatimah , Mohamad Yunus Rossita 
Published: April 2018

The von Mises distribution is the ‘natural’ analogue on the circle of the Normal distribution on the real line and is widely used to describe circular variables. The distribution has two parameters, namely mean direction, and concentration parameter, κ. Solutions to the parameters, however, cannot be derived in the closed form. Noting the relationship of the κ to the size of sample, we examine the asymptotic normal behavior of the parameter. The simulation study is carried out and Kolmogorov-Smirnov test is used to test the goodness of fit for three level of significance values. The study suggests that as sample size and concentration parameter increase, the percentage of samples follow the normality assumption increase.
On bonded indian and uniformly parallel insertion systems and their generative power
Authors: Yosman Ahmad Firdaus , Holzer Markus , Truthe Bianca , Wan Heng Fong , Turaev Sherzod 
Published: April 2018

Insertion is an operation in formal language theory that generalizes the operation of concatenation of words, where its variants allow the operation in different ways. Parallel insertion is a variant of insertion that simultaneously adds words between all letters of a word and also at the right and left extremities. In previous research, restrictions on the applicability have been imposed leading to so-called bonded insertion systems with a sequential and a parallel variant. Motivated by the atomic behavior of chemical compounds in the process of chemical bonding, the generative power of bonded insertion systems has been investigated where a language hierarchy was obtained. In this paper, we introduce new variants of bonded parallel insertion systems, namely bonded Indian parallel insertion systems and bonded uniformly parallel insertion systems. We present some results regarding the generative power of these new systems and a language hierarchy.
Older adults’ experiences of patient involvement in transitional care: a qualitative systematic review protocol
Authors: Høy Bente , Ludvigsen Mette Spliid 
Published: April 2018

Review question/objective:
The objective of this review is to identify and synthesize older adult's experiences of patient involvement in transitional care between hospital and home. The purpose is to build theory to inform future research and clinical practice.
The review will specifically address the following research questions:What preference and meaning do older adults ascribe to patient involvement in transitional care between hospital and home?What challenges, facilitators and outcomes do older adults experience in transitional care between hospital and home?How do older adults experience their capacity and performance of patient involvement in transitional care between hospital and home?How do older adults experience their level of patient involvement in transitional care between hospital and home?