bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphonamidates of Camphorsultam: Versatile Building Blocks for the Synthesis of P‐Chiral Phosphorous(V) Compounds
Authors: Yamamoto Yasutomo , Kambara Yurika , Matsumoto Ayase , Murata Miku , Nakamoto Mizuki , Ishiura Tomoe , Nakai Sakura , China Hideyasu , Watanabe Kenji , Miyawaki Akari , Matsuoka Junpei 
Published: November 2024

AbstractCamphorsultam was utilized for the optical resolution of P‐chiral phosphorous compounds. After chromatographic separation of diastereomeric RP‐ and SP‐phosphonamidate intermediates, subsequent substitution reactions with phenol derivatives yielded P‐chiral phosphonic acid aryl esters with excellent enantioselectivities. In these processes, chiral sulfonamide of camphorsultam demonstrated superior abilities as an optical‐resolving agent and a good leaving group. This method was applied to the synthesis of P‐chiral phosphinic esters, phosphonamidates, and thiophosphonate diesters.
Sustainable Green Solvents for Lead Halide Perovskites
Authors: Meng Fanning , Cheng Long , Wang Fang , Chen Kaifei , Sun Zhiyan , Wang Guiqiang 
Published: November 2024

AbstractLead halide perovskites have revolutionized the field of optoelectronics and attracted worldwide attention due to their outstanding semiconducting characteristics. Meanwhile, solution processability and printability of the perovskite allow the commercialization of perovskite solar cells (PSCs) profitable. However, deposition of the perovskite films usually uses polar aprotic solvents. The popular antisolvents are aromatics or aromatic halogenated hydrocarbons. All of them have a high risk of toxicity and flammability. To reduce the adverse effects on the environment and operators and enhance the sustainability of perovskite technologies, researchers have made lots of efforts to study sustainable green solvents. Herein, the selection criteria of green solvents are surveyed. Methods of solubility prediction of precursor solvents are comprehensively discussed from the perspectives of polarity and Lewis acid–base chemistry. The significance of antisolvent polarity and boiling point is emphasized. Research advances in green solvents are summarized. Finally, this review presents in‐depth insights into green‐solvent‐processable perovskites and highlights research directions for perovskite modules in the future. It lays a good foundation for the commercialization and sustainable development of PSCs.
A Chemically Defined Culture for Tooth Reconstitution
Authors: Zhang Ziwei , Hu Hong , Xu Zhiheng , Shan Ce , Chen Hanyi , Xie Kun , Wang Kun , Wang Yifu , Zhu Qing , Yin Yike , Cai Haoyang , Zhang Yunqiu , Li Zhonghan 
Published: November 2024

AbstractIt is known for decades that dental epithelium and mesenchyme can reconstitute and regenerate a functional tooth. However, the mechanism of tooth reconstitution remains largely unknown due to the lack of an efficient in vitro model. Here, a chemically defined culture system is established that supports tooth reconstitution, further development with normal anatomy, and prompt response to chemical interference in key developmental signaling pathways, termed as toothoids. By using such a system, it is discovered that, during reconstitution, instead of resetting the developmental clock, dental cells reorganized and restarted from the respective developmental stage where they are originally isolated. Moreover, co‐stimulation of Activin A and Hedgehog/Smoothened agonist (SAG) sustained the initial induction of tooth fate from the first branchial arch, which would be otherwise quickly lost in culture. Furthermore, activation of Bone Morphogenetic Protein (BMP) signaling triggered efficient enamel formation in the late‐stage toothoids, without affecting the normal development of ameloblasts. Together, these data highlight the toothoid culture as a powerful tool to dissect the molecular mechanisms of tooth reconstitution and regeneration.
Possible Superconductivity Transition in Nitrogen‐Doped Lutetium Hydride Observed at Megabar Pressure
Authors: Zhao Xingbin , Huang Yu , Ma Shuailing , Song Hao , Cao Yanwei , Jiang Hao , Huang Yanping , Cui Tian 
Published: November 2024

AbstractThe pursuit of room‐temperature superconductivity at an accessible synthetic pressure has been a long‐held dream for both theoretical and experimental physicists. Recently, a controversial report by Dasenbrock‐Gammon et al. claims that the nitrogen‐doped lutetium trihydride exhibits room‐temperature superconductivity at near‐ambient pressure. However, many researchers have failed to independently reproduce these results, which has sparked intense skepticism on this report. In this work, a LuH2±xNy sample is fabricated using high‐pressure and high‐temperature methods. The composition and structural characterization are the same as the aforementioned near‐ambient superconductor. In situ X‐ray diffraction investigations indicate that a high‐pressure phase transition toward Fmm‐LuH3±xNy occurred in the sample at 59 GPa. The temperature‐dependent resistance measurements reveal that two possible superconductivity transition are observed at 95 GPa, with Tc1 ≈6.5 K for high‐Tc phase and Tc2 ≈2.1 K for low‐Tc phase, arising from the disparate phases in the sample. Resistivity measurements in the Fmm‐LuH3±xNy phase under varying magnetic fields exhibited characteristics consistent with superconductivity, with an upper critical field μ0Hc2(0) of 3.3 T measured at 163 GPa. This work is expected to shed some light on the controversy surrounding superconductivity in the nitrogen‐doped lutetium hydride system.
Advancing Neural Networks: Innovations and Impacts on Energy Consumption
Authors: Fedorova Alina , Jovišić Nikola , Vallverdù Jordi , Battistoni Silvia , Jovičić Miloš , Medojević Milovan , Toschev Alexander , Alshanskaia Evgeniia , Talanov Max , Erokhin Victor 
Published: November 2024

AbstractThe energy efficiency of Artificial Intelligence (AI) systems is a crucial and actual issue that may have an important impact on an ecological, economic and technological level. Spiking Neural Networks (SNNs) are strongly suggested as valid candidates able to overcome Artificial Neural Networks (ANNs) in this specific contest. In this study, the proposal involves the review and comparison of energy consumption of the popular Artificial Neural Network architectures implemented on the CPU and GPU hardware compared with Spiking Neural Networks implemented in specialized memristive hardware and biological neural network human brain. As a result, the energy efficiency of Spiking Neural Networks can be indicated from 5 to 8 orders of magnitude. Some Spiking Neural Networks solutions are proposed including continuous feedback‐driven self‐learning approaches inspired by biological Spiking Neural Networks as well as pure memristive solutions for Spiking Neural Networks.
Ultrasound evaluation of peripheral intravenous catheter thrombus formation associated with intravenous flucloxacillin administration: A prospective observational pilot study
Authors: Bulmer Andrew C. , Nightingale Rachael , Hewage Wenu , Keijzers Gerben , Snelling Peter J. 
Published: November 2024

AbstractPurposeThe purpose of this study was to sonographically evaluate whether intravenous (IV) flucloxacillin administration was associated with an increased risk of peripheral intravenous catheter (PIVC) thrombus formation.MethodsThis observational study included participants enrolled as a convenience sample from a larger prospective study of patients with cellulitis receiving IV antibiotics in the emergency department. Point‐of‐care ultrasound was used to evaluate the PIVCs for thrombus formation after insertion and at specified timepoints after IV administration of antibiotic or saline solution through to discharge. The primary endpoint included the presence and length of the thrombus in proximity of the catheter tip.ResultsBetween May 2021 and June 2022, 25 participants were enrolled and received either IV flucloxacillin (n = 10), other IV antibiotics (n = 8) or no IV antibiotics (control; n = 7). PIVC thrombus formation was sonographically detected in 100%, 67% and 17% of patients in flucloxacillin, other and control groups at 6–12 h (flucloxacillin vs. control; P = 0.015), with a mean length of 17.4 ± 8.1 (flucloxacillin vs. control; P = 0.46), 15.5 ± 13.4 (other vs. control; P = 0.73) and 7.3 ± 17.9 mm (control), respectively. Thrombus formation increased significantly in the flucloxacillin group over time (0–>12 h; P = 0.03) but did not increase in the other or control groups.DiscussionThe administration of IV flucloxacillin appears to promote the formation of a PIVC thrombus visible on ultrasound, but the clinical implications are uncertain. Although the vast majority appear to be asymptomatic, they have the potential to become a precursor to thrombophlebitis and lead to early PIVC failure.ConclusionsIt was feasible to identify and measure PIVC thrombus sonographically. Ultrasound showed that IV flucloxacillin administration appeared to be associated with more frequent formation of PIVC thrombus, with these increasing in length over time. Further research is required to confirm these findings in larger studies and to identify any clinical implications of the findings.
Social factors associated with aspirin desensitization and diagnosis age in aspirin‐exacerbated respiratory disease
Authors: Asthana Shravan , Workman Alan D. , Lerner David K. , Randell Rani M. , Lopez Dana F. , Kohanski Michael A. , Palmer James N. , Adappa Nithin D. , Douglas Jennifer E. , Bosso John V. 
Published: November 2024

Key points
Racial disparities influence the completion of aspirin (ASA) desensitization and ASA‐exacerbated respiratory disease (AERD) diagnosis age.
Public insurance correlates with an official AERD diagnosis after age 50.
Social factors, including race and insurance status, impact AERD diagnosis and adherence to ASA desensitization.
Unwanted disorders and xenogeneic graft‐versus‐host disease in experimental immunodeficient mice: How to evaluate and how to report
Authors: Monzavi Seyed Mostafa , Muhammadnejad Samad , Mansouri Vahid , Ashraf Hami , Ahmadbeigi Naser 
Published: November 2024

AbstractHuman‐derived tumor models are essential for preclinical development of new anticancer drug entities. Generating animal models bearing tumors of human origin, such as patient‐derived or cell line–derived xenograft tumors, is dependent on immunodeficient strains. Tumor‐bearing immunodeficient mice are susceptible to developing unwanted disorders primarily irrelevant to the tumor nature; and if get involved with such disorders, reliability of the study results will be undermined, inevitably confounding the research in general. Therefore, a rigorous health surveillance and clinical monitoring system, along with the establishment of a strictly controlled barrier facility to maintain a pathogen‐free state, are mandatory. Even if all pathogen control and biosafety measures are followed, there are various noninfectious disorders capable of causing tissue and multiorgan damage in immunodeficient animals. Therefore, the researchers should be aware of sentinel signs to carefully monitor and impartially report them. This review discusses clinical signs of common unwanted disorders in experimental immunodeficient mice, and how to examine and report them.
Long‐Term Follow Up in Anti‐Contactin‐1 Autoimmune Nodopathy
Authors: Caballero‐Ávila Marta , Martín‐Aguilar Lorena , Pascual‐Goñi Elba , Michael Milou R. , Koel‐Simmelink Marleen J.A. , Höftberger Romana , Wanschitz Julia , Alonso‐Jiménez Alicia , Armangué Thais , Baars Adája Elisabeth , Carbayo Álvaro , Castek Barbara , Collet‐Vidiella Roger , De Winter Jonathan , del Real Maria Ángeles , Delmont Emilien , Diamanti Luca , Doneddu Pietro Emiliano , Hiew Fu Liong , Gallardo Eduard , Gonzalez Amaia , Grinzinger Susanne , Horga Alejandro , Iglseder Stephan , Jacobs Bart C. , Jauregui Amaia , Killestein Joep , Pozza Elisabeth Lindeck , Martínez‐Martínez Laura , Nobile‐Orazio Eduardo , Ortiz Nicolau , Pérez‐Pérez Helena , Poppert Kai‐Nicolas , Ripellino Paolo , Roche Jose Carlos , Rodriguez de Rivera Franscisco Javier , Rostasy Kevin , Sparasci Davide , Tejada‐Illa Clara , Teunissen Charlotte C.E. , Vegezzi Elisa , Xuclà‐Ferrarons Tomàs , Zach Fabian , Wieske Luuk , Eftimov Filip , Lleixà Cinta , Querol Luis 
Published: November 2024

ObjectiveTo analyze long‐term clinical and biomarker features of anti‐contactin‐1 (CNTN1) autoimmune nodopathy (AN).MethodsPatients with anti‐CNTN1+ autoimmune nodopathy detected in our laboratory from which clinical information was available were included. Clinical features and treatment response were retrospectively collected. Autoantibody, serum neurofilament light chain (sNfL), and serum CNTN1 levels (sCNTN1) were analyzed at baseline and follow up.ResultsA total of 31 patients were included. Patients presented with progressive sensory motor neuropathy (76.7%) with proximal (74.2%) and distal involvement (87.1%), ataxia (71.4%), and severe disability (median INCAT at nadir of 8). A total of 11 patients (35%) showed kidney involvement. Most patients (97%) received intravenous immunoglobulin, but only 1 achieved remission with intravenous immunoglobulin. A total of 22 patients (71%) received corticosteroids, and 3 of them (14%) did not need further treatments. Rituximab was effective in 21 of 22 patients (95.5%), with most of them (72%) receiving a single course. Four patients (12.9%) relapsed after a median follow up of 25 months after effective treatment (12–48 months). Anti‐CNTN1 titers correlated with clinical scales at sampling and were negative after treatment in all patients, but 1 (20/21). sNfL levels were significantly higher and sCNTN1 significantly lower in anti‐CNTN1+ patients than in healthy controls (sNfL: 135.9 pg/ml vs 7.48 pg/ml, sCNTN1: 25.03 pg/ml vs 22,186 pg/ml, p < 0.0001). Both sNfL and sCNTN1 returned to normal levels after successful treatment.InterpretationPatients with anti‐CNTN1+ autoimmune nodopathy have a characteristic clinical profile. Clinical and immunological relapses are infrequent after successful treatment, suggesting that continuous treatment is unnecessary. Anti‐CNTN1 antibodies, sNfL, and sCNTN1 levels are useful to monitor disease status in these patients. ANN NEUROL 2025;97:529–541
Ultrafast Luminescence Detection with Selective Adsorption of Carbon Disulfide in a Gold(I) Metal−Organic Framework
Authors: Yoshino Haruka , Saigo Masaki , Ehara Takumi , Miyata Kiyoshi , Onda Ken , Pirillo Jenny , Hijikata Yuh , Takaishi Shinya , Kosaka Wataru , Otake Ken‐ichi , Kitagawa Susumu , Miyasaka Hitoshi 
Published: November 2024

AbstractAlthough a widely used and important industrial chemical, carbon disulfide (CS2) poses a number of hazards due to its volatility and toxicity. As such, the development of multifunctional materials for the selective capture and easy recognition of CS2 is one of the crucial issues. Herein, we demonstrate completely selective CS2 adsorption among trials involving H2O, alcohols, volatile organic compounds (including thiol derivatives), N2, H2, O2, CH4, CO, NO, and CO2. We also showcase its fine detection using remarkable luminescent response in a gold(I)‐based metal−organic framework (MOF) of {ZnII(pz)[AuI(CN)2]2} (pz=pyrazine; 1) with a two‐fold interpenetration network. Ex situ single crystal X‐ray diffraction for 1 and CS2‐accommodated 1 suggested that the Au ⋅⋅⋅ Au atoms are not only luminescent centers but also act as interaction sites for CS2 modulating the Au ⋅⋅⋅ Au contacts. These experiments revealed the specificity of CS2 and how changes in the CS2‐induced structure. Based on the obtained structural transformation, 1 exhibited a sensitive detecting ability for CS2 with an ultrafast response time of less than 10 s. Moreover, ex situ time‐resolved photoluminescence analyses developed in this work implied that CS2 varied the energetic relaxation at the excited states related to the luminescent efficiency of the resultant MOF system.
Redox‐Neutral Carboxylation of Benzylic Tertiary C−H Bonds with Carbon Dioxide
Authors: Li Jun‐Li , Zhang Shan‐Shan , Jiang Liang‐Liang , Li Hao‐Yuan , Zhu Can‐Ming , Yuan Pan‐Feng , Yang Zhao , Yang Xiu‐Long , Zhong Jian‐Ji , Meng Qing‐Yuan 
Published: November 2024

AbstractThe direct catalytic carboxylation of benzylic tertiary C−H bonds with CO2 for the synthesis of all‐carbon quaternary carboxylic acids represents a significant challenge. Here, we present a redox‐neutral approach to address this difficulty by leveraging the synergistic interplay between photocatalysis and cascade hydrogen abstraction cycles. Remarkably, this strategy eliminates the need for sacrificial electron donors, electron acceptors, or stoichiometric additives, offering enhanced atom economy and environmental sustainability. It is particular that the combination of α‐amino alkyl radicals with sulfur radicals generated in situ from the decomposition of DMSO was employed to realize the abstraction of benzylic tertiary C−H bonds. Our method enables the direct synthesis of a diverse array of benzylic quaternary carboxylic acids with excellent functional group tolerance as well as the derivatization of bioactive molecules and the gram‐scale synthesis of pharmaceuticals under mild reaction conditions.
Electrochemical Evaluation of Redox Active Cobalt‐Oxyquinolinate Complex Layered on Reduced Graphene Oxide for Hybrid Supercapacitor Application
Authors: Pandimadevi Lishavi S. , Thameem Ansari Mohamed Ali , Karthick Raja K. , Kumar Vivek , Chinnathambi V. 
Published: November 2024

ABSTRACTThe redox active organometallic compounds are the prominent supercapacitor electrode materials due to the attractive properties like stable redox scheme, good electron transfer mediator, and low oxidation potential. The key advantage of the organometallic compounds is that the electronic property of the electrode can be modified by altering and functionalizing the ligands around the metal atom. In this work, we synthesized cobalt‐oxyquinolinate (Co‐Q) organometallic compound by solvothermal method. To improve the electrical conductivity, the reduced graphene oxide (RGO) is grafted on Co‐Q. The electrochemical behaviour of Co‐Q is improved by the addition of RGO. The specific capacitance of Co‐Q layered on RGO is greater (1206 mF cm−2) than Co‐Q (670 mF cm−2) at current density of 1 mA cm−2. This is due to the increase in active sites after the incorporation of RGO on Co‐Q; further, this promotes the diffusion process. The fundamental electrochemical analyses, including cyclic voltammetry, galvanostatic charge–discharge analysis, and electrochemical impedance analysis, provided the information about the electrochemical energy storage performance. Dunn's method is used to understand the diffusion and capacitive contributions of the electrode material during energy storage. From the electrochemical analysis, Co‐Q layered on RGO is a suitable material for the energy storage application due to its high diffusion and stability.
Dielectric Properties of Pristine and Green‐Synthesized Hematite Nanomaterials Vis‐À‐Vis Their Dependence on Porosity and Particle Size
Authors: Sarkar Toton , Kundu Sani , Bhattacharjee Ashis 
Published: November 2024

ABSTRACTHematite is obtained using different concentrations of P. tuberosa flower extract. XRD and Raman studies confirm the formation of nanometric size (20–30 nm) and the corundum structure. Particle size depends on the extent of flower extract used for synthesis. Frequency and temperature dependent dielectric constant, dielectric loss, ac/dc conductivity and electric modulus have been explored. Large dielectric constant values (6 × 103−40 × 103) at low frequency under room temperature are observed. Dielectric constant () depends on frequency, temperature, particle size and porosity. The nature of the frequency dependence of can be explained with the help of the Maxwell‐Wagner‐Koop's theory. Correlation between particle size and dielectric constant is attributed to significant lattice distortion resulting from reduced grain size. AC conductivity is analyzed with Jonscher's power law, and correlated‐barrier‐hopping type of conduction mechanism is proposed in these nanomaterials. Temperature dependence of DC conductivity confirms semiconducting behavior of hematite. Investigation into the electric modulus reveals that both electrical conduction and dielectric polarization are governed by a common mechanism. Present study explores into the process of crystal growth influenced by the plant extract and examines its impact on the dielectric property.
Ubiquitin‐Independent Degradation: An Emerging PROTAC Approach?
Authors: Li Tiantian , Hogenhout Saskia A. , Huang Weijie 
Published: November 2024

ABSTRACTTargeted protein degradation (TPD) has emerged as a highly promising approach for eliminating disease‐associated proteins in the field of drug discovery. Among the most advanced TPD technologies, PROteolysis TArgeting Chimera (PROTAC), functions by bringing a protein of interest (POI) into proximity with an E3 ubiquitin ligase, leading to ubiquitin (Ub)‐dependent proteasomal degradation. However, the designs of most PROTACs are based on the utilization of a limited number of available E3 ligases, which significantly restricts their potential. Recent studies have shown that phytoplasmas, a group of bacterial plant pathogens, have developed several E3‐ and ubiquitin‐independent proteasomal degradation (UbInPD) mechanisms for breaking down host targets. This suggests an alternative approach for substrate recruitment and TPD. Here, we present existing evidence that supports the feasibility of UbInPD in eukaryotic cells and propose candidate proteins that can serve as docking sites for the development of E3‐independent PROTACs.
AtLEC2‐Mediated Enhancement of Endoplasmic Reticulum‐Targeted Foreign Protein Synthesis in Nicotiana benthamiana Leaves: Insights From Transcriptomic Analysis
Authors: Ocampo Carolina G. , Vignolles Florencia , Pombo Marina A. , Colombo Maria Laura , Rosli Hernan G. , Petruccelli Silvana 
Published: November 2024

ABSTRACTMany proteins used in industrial and pharmaceutical applications are typically synthesized within the secretory pathway. While yeast and mammalian cells have been engineered to enhance the production of endomembrane‐targeted proteins, similar strategies in plant cells remain underexplored. This study investigates the potential of arabidopsis leafy cotyledon 2 (AtLEC2), a key regulator of seed development, to enhance the production of proteins targeted to the endoplasmic reticulum (ER) in Nicotiana benthamiana leaves. Through transient expression experiments, we demonstrate that AtLEC2 selectively increases the production of ER‐targeted GUS without affecting its cytosolic variant. Moreover, leaves agroinfiltrated with AtLEC2 show a significant increase in ER‐GFP accumulation compared to controls lacking AtLEC2. Transcriptomic analysis reveals that AtLEC2 promotes ribosome and chloroplast biogenesis, along with the upregulation of genes involved in photosynthesis, translation, and membrane synthesis. Notably, seed‐specific poly(A) binding proteins involved in RNA stability and translation initiation, as well as 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase—linked to ER hypertrophy—are highly upregulated. This study establishes a novel connection between AtLEC2 and the enhancement of ER‐targeted foreign protein synthesis, paving the way for innovative strategies in plant cellular engineering.