bluuebunny/crossref_metadata_2025_split huggingface dataset:
New formula for predicting standard liver and spleen volumes in Chinese adults
Authors: Yang Longbao , Zhao Gang , Tantai Xinxing , Xiao Cailan , Yang Caifeng , Zhang Ying , Dong Lei , Li Hong 
Published: October 2019

Abstract
BACKGROUNDThe liver volume and spleen volum are useful index for cirrhosis patients with esphageal varices. But the calculation of the volume is time-consuming and boring. To solve the problem, we successfully established the liver and spleen volume formula using the body surface area. We compared the liver volume formula with other four formulas, which be proved with highest accuracy and lowest error. Until now, except for the new spleen volume formula in the research, there are few reports about it.AIMTo obtain a reference range of morphological indices, and to establish a formula to accurately predict the standard liver and spleen volumes in Chinese adults.METHODSComputed tomography was used to calculate the estimated total liver volume and spleen volume of 305 Chinese adults without any diseases which could influence the volumes of these two organs. Gender, age, body height, body weight, body surface area and body mass index were determined. Correlation analysis and step-wise multiple linear regression analysis were performed to evaluate the impact of each parameter on the liver and spleen volumes, and then a formula to predict the liver and spleen volumes was established. Finally, the results obtained with the new liver volume formula with existing formulas in a validation group were compared.RESULTSThe average liver and spleen volume values were 1043.18 ± 244.60 cm3 and 175.07 ± 88.15 cm3, respectively. Age, body height, body weight, body surface area and body mass index were significantly correlated with liver and spleen volume. Body surface area showed the strongest correlation with liver volume and spleen volume( p<0.005 and p<0.001). Based on these results, new formulas to calculate the standard liver volume and standard spleen volume were established.CONCLUSIONSCompared the new liver volume formula with the existing formula, it is found that the new liver volume is more accurate. And the accuracy of the spleen volume formula is acceptable. Core tip: To solve the problem of time-consuming and boring in calculating the liver and spleen volume, we successfully established the liver and spleen volume formula can be used in Chinese adult. Though there are some reports about the liver volume, but it is different in spleen volume. The liver volume and spleen volume radio is an useful index to predict the esophageal varices and bleeding risk for cirrhosis patients. Only liver volume formula is not enough, the finding of the spleen volume is very meaningful.
Construction of a High-density Genetic Linkage Map and QTL Analysis of Resistance to Cucumber Mosaic Virus in Luffa cylindrica (L.) Roem. Based on Specific Length Amplified Fragment Sequencing
Authors: Lou Lina , Liu Zhe , Liu Xiaohong , Su Xiaojun 
Published: October 2019

Abstract
Background: Luffa cylindrica L. is an economically important vegetable crop that is consumed globally. Cucumber mosaic virus (CMV) is an important virus affecting Luffa spp. No specific high-density maps have been constructed owing to a lack of efficient markers. Furthermore, no genes or quantitative trait loci (QTLs) are reportedly responsible for CMV resistance in Luffa spp. The development of next-generation sequencing has enabled discovery of single nucleotide polymorphisms and high-throughput genotyping of large populations. Results: A total of 271.01 Mb pair-end reads were generated. The average sequencing depth was 86.19× in both maternal and parental lines, and 14.57× in each F 2 individual. When filtering low-depth specific locus amplified fragment (SLAF) tags, 100,077 high-quality SLAFs were detected, and 7,405 of them were polymorphic. Finally, 3,701 of the polymorphic markers were selected for genetic map construction, and 13 linkage groups were generated. The map spanned 1,518.56 cM with an average distance of 0.41 cM between adjacent markers. Our results also revealed that CMV resistance was regulated by QTLs. Based on the newly constructed high-density map, two loci located on chromosome 1 (100.072 ~ 100.457 cM) and 4 (42.475 ~ 44.398 cM) were identified to regulate CMV resistance in L. cylindrica . A gag-polypeptide of LTR copia-type retrotransposon was predicted as the candidate gene responsible for CMV resistance in L. cylindrica . Conclusions: A high-density linkage map of L. cylindrica was constructed using SLAF. QTL mapping based on CMV disease phenotypes of F 2 led to the identification of two QTL on chromosome 1 and 4, respectively. Kompetitive allele-specific PCR analysis of 60 F 2 individuals, which gave rise to F 2:3 individuals, was carried out. We found that the QTL on chromosome 1 was associated with CMV resistance. Mapping of CMV QTL combined with the transcriptomic sequence alignment identified a gag-polypeptide of LTR copia-type retrotransposon as the most likely causal gene.
Are The Neutrophil-to-lymphocyte, Platelet-to-lymphocyte And Monocyte-to-lymphocyte Ratios Predictive Factors For The Retinopathy Of Prematurity?
Authors: Uğurlu Adem , İçel Erel , Taşlı Nurdan Gamze , Yılmaz Hayati , Uçak Turgay , Karakurt Yücel 
Published: October 2019

Abstract
Purpose: In this study, we aimed to evaluate the possible relationship between the neutrophil-to-lymphocyte, monocyte-to-lymphocyte and platelet-to-lymphocyte ratio and retinopathy of prematurity (ROP). Method: The data of 348 patients who applied to Erzincan University Ophthalmology Unit for screening the retinopathy of prematurity were analyzed retrospectively. One hundred sixty seven patients who were collected CBC samples within the first 72 hours after delivery and who met the inclusion criteria were included in the study. Infants with a gestational age of ≤35 week were screened for ROP. Pateints were divided into two groups. Group 1 was involved the patients with the diagnosis of ROP and group 2 was involved the normal patients (no ROP). The levels of NLR, PLR and MLR were determined in two groups. Results: Fifty nine patients who were detected ROP are in group 1 and 108 patients who were not seen ROP are in group 2 in the study. The mean gestational age at birth of the patients was 30,4 ± 2,1 [26-34] weeks in group 1 and 33,7 ± 1,7 [27-35] weeks in group 2.( P =0.004) The mean gestational weigth at birth was 1927,2 ± 158,4 [1690-2300] gram in group 1 and 2169,1 ± 283,1 [1750-3100] gram in group 2. ( P <0.001) With the result of logistic regression analysis, gestational age [Odds Ratio(OR): 0.531, 95%CI: 0.388-0.726, P <0.001], NLR [OR:34.849, 95%CI: 2.091-580.779, P :0.013] and PLR [OR: 1.067, 95%CI: 1.034-1.110, P <0.001] were detected the independent risk factors for ROP. Conclusion: Our study revealed that higher NLR and PLR which are evaluated with in first 72h after birth is an independent predictor of ROP.
Prevalence of husband antenatal care attendance and associated factors among husbands whose wives gave birth in the last twelve months in Enebsiesarmider District, Northwest Ethiopia, 2018.
Authors: Abebe Haimanot 
Published: October 2019

Abstract
Background Globally, husband attendance of skilled maternal ANC care remains a challenge to safe motherhood. Even though husband attendance in antenatal care is one of the strategies for enhancing reproductive and sexual health in Ethiopia, the magnitude of husband attendance in ANC is not well investigated in the study area. Therefore, this study aimed to assess husband antenatal care attendance and associated factors among husbands whose wives gave birth in the last twelve months prior to the study in Enebsiesarmider district, Northwest Ethiopia.Methods A Community-based cross-sectional study was employed to assess husband antenatal care attendance and associated factors among husbands whose wives gave birth in the last twelve months in Enebsiesarmider district, Northwest Ethiopia. The study was conducted from February 10-March 10, 2018. A total of 402 participants were involved in the study. Multi stage sampling method was used to recruit study participants. Data were collected using structured interviewer administered questionnaire. Data were entered using epi Data software and exported to SPPS for analysis. Descriptive statistics including mean, proportion were used to describe study variables. Binary and multivariable logistic regression was employed to describe variables in relation to the outcome variable.Result: The prevalence of husband antenatal care attendance was found to be 31.8% [95%CI, 27.4-36.3]. Attending secondary education and above [AOR 1.93, 95%CI, 1.14-3.26], good antenatal care knowledge [AOR 3.30, 95%CI, 2.02-5.39] and hadn’t health system barriers [AOR 2.32, 95%CI, 1.35-4.00] were statistically associated with husband antenatal care attendance.Conclusion Husband ANC attendance was found to be low in the study area. Regional health department shall design behavioral change interventions to reducing health system pitfalls towards ANC in the study area, furthermore, enabling all pregnant women to be booked for ANC and providing invitation letter to their husbands in the subsequent ANC visits seems essential to initiate husband ANC attendance.
Incidence and predictors of diabetic ketoacidosis among children with type 1 diabetes mellitus in Western Amhara Referral Hospitals, Northwestern Ethiopia, 2018: A Retrospective Follow-Up Study
Authors: Zeleke Melkamu Siferih , Kibret Getiye Dejenu , Gebre Tsige , Birhanu Molla Yigzaw , Leshargie Cheru Tesema 
Published: October 2019

Abstract
Background Diabetic ketoacidosis remains a major cause of morbidity, hospitalizations and mortality in children with established type 1 diabetes mellitus. Therefore, this study aimed to determine the incidence and predictors of diabetic ketoacidosis among children with established type 1 diabetes mellitus at Western Amhara region.Method Institution-based retrospective follow-up study was done on 393 children with established type 1 diabetes mellitus registered between September 2013 and September 2017 in Western Amhara referral hospitals. The collected data was entered into Epidata version 4.2 and further analysis were done using STATA version 14.1. Negative Binomial Poisson Regression analysis model was used.Result The cumulative incidence and incidence density rate of diabetic ketoacidosis among children with established type 1 diabetes mellitus in western Amhara referral hospitals was 63.9% and 41.5 per 100 person-years respectively. The incidence of diabetic ketoacidosis increased with age at diagnosis [ARR:2.61, p-value<0.001], siblings only care givers [ARR:1.87, p-value <0.001], fathers only [ARR:1.51, p-value=0.004],omission of insulin (ARR:1.58, p-value <0.001), lower frequency of clinical visits [ARR:2.35, p-value=0.007] and baseline insulin dose >1.2 u/kg/day [ARR:1.39, p-value=0.015], diabetic education (no) [ARR:1.52, p-value=0.011]. But the risk was decreased with baseline insulin type (Lente and regular) (ARR; 0.73, p-value =0.006), base line insulin dose <0.6u/kg/day (ARR: 0.5, p-value=0.034) and community health insurance membership (no membership) [ARR: 0.49, p-value <0.001]. In general, this study revealed that a substantial number of patients had at least one episode of diabetic ketoacidosis and a higher rate of diabetic ketoacidosis.
Overexpression of ThSOS from Tamarix hispida improves salt tolerance
Authors: Liu Zhongyuan , Xie Qingjun , Tang Feifei , Wu Jing , Dong Wenfang , gao caiqiu 
Published: October 2019

Abstract
Highlights

● The functional characterization of ThSOS genes were investigated by bioinformatics analysis and molecular characterization.

● ThSOS genes can respond to abiotic stresses (salt and drought) and hormone treatment (ABA).

● ThSOS3 gene overexpression increased ROS-scavenging capability and decreasing lipid peroxidation in cell membrane.

● ThSOS3 could effectively enhance the tolerance of transgenic T. hispida and Arabidopsis to salt stress.
The second pregnancy has no effect in the incidence of macrosomia: A cross sectional survey in two western Chinese regions
Authors: Luo Li , Wang Lianlian , Zeng Huan , Peng Feng , Shi Zumin , Xu Xianglong , Saffery Richard , Han Ting-Li , Xie Yaojie , Zhao Yong 
Published: October 2019

Abstract
After the implementation of the universal two-child policy in 2015 in China, the increase in parity has led to an increase in adverse pregnancy outcomes. The impact of parity on the incidence of fetal macrosomia has not been fully confirmed in China.This study aimed to explore the differences in the incidence of fetal macrosomia between first and second pregnancies in Western China. A total of 1598 pregnant women from three hospitals were investigated by means of a cross-sectional study from August 2017 to January 2018. Participants were recruited by a convenience sampling method and divided into first and second pregnancy groups. These groups included 1094 primiparas and 504 women giving birth to their second child. Univariate and multivariate logistic regression analyses were performed to discuss the differences in the incidence of fetal macrosomia in first and second pregnancies. No significant difference was found in the incidence of macrosomia in the first pregnancy group (7.2%) and the second pregnancy group (7.1%). In the second-time pregnant mothers, no significant association was found between the macrosomia of the second child (5.5%) and that of the first child (4.7%). In conclusion: the incidence of macrosomia in Western China is not affected by second childbirth, that is not affected by low parity. History of first child macrosomia was not a predictor of second child macrosomia.
Self-appraisal of caregiving in family caregivers of older adults with dementia in Iran: a content analysis study
Authors: Farhadi Akram , Mohammadi Farahnaz , Foroughan Mahshid , Sadeghmoghadam Leila , Nazari Shima , Mortazavi Seyede Salehe 
Published: October 2019

Abstract
Background The concept of caring appraisal, which includes positive and negative aspects of care, has been considered as one of the key concepts in caregivers' studies. The aim of the present study was to investigate the self-appraisal concept of caring from the viewpoint of family caregivers in the elderly with dementia in Iran.Methods This study was based on qualitative analysis. Data were collected through in-depth and semi-structured interviews. Twelve participants (family caregivers of elderly people with dementia) were interviewed between January and September 2016. They were selected from visitors to the Alzheimer's Association of Iran and Yadman Memorial Clinic (Tehran- Iran). The interviews were recorded and transcribed. The transcribed texts were analyzed using inductive qualitative content analysis recommended by Graneheim and Lundman (2004).Results The study explored two main categories include "perceived burden", "Losses and Threats," "satisfaction with care", "Personal growth", "caregiving gains", "philosophy of care" and 22 subcategories.Conclusion According to the results of this study, the family caregivers’ appraisal of their care not only does not have negative aspects but also covers a large number of positive aspects, in which the cultural and social conditions prevailing in the Iranian society play a significant role in the formation of these positive aspects.
Influence of Contrasting Soil Moisture Conditions on Carbon Dioxide and Nitrous Oxide Emissions from Terminated Green Manures
Authors: Singh Hardeep , Kandel Tanka P. , Gowda Prasanna H. , Somenahally Anil , Northup Brian K. , Kakani Vijaya G. 
Published: October 2019

Core Ideas
Impacts of soil moisture at incorporation of two legumes on the CO2 and N2O emissions were studied.
Availability of soil moisture led to rapid mineralization of biomass C and N.
Legume incorporation based on short‐term rainfall forecast did not avoid large N2O emissions.
Carbon dioxide (CO2) and nitrous oxide (N2O) emissions from decomposing legume green manures largely depend on soil moisture. A potential management to mitigate N2O emissions could be to incorporate legumes during dry periods based on the short‐term rainfall forecast. The present mesocosm study was designed to examine the impact of soil moisture due to different timing of rainfall after incorporation of legume cover crops on CO2 and N2O emissions. Two timings of rainfall were simulated as early and late rainfall that received 80 mm deionized water at or 1 wk after incorporation of the legumes. An additional 20 mm water was added after 2 wk of the first simulated rainfalls. Gas fluxes of CO2 and N2O were measured using closed chamber method for 28 d incubation assay. Soil concentrations of NH4+ and NO3–, concentrations of N in undecomposed biomass, and abundances of denitrifier bacterial genes (nirK, nirS, and nosZ) and arbuscular mycorrhiza fungi (AMF) were determined at weekly intervals. Carbon dioxide emissions increased immediately after the first simulated rainfall events and peaked around Day 2 to 3, whereas N2O emissions reached peak level around Day 8 to 10 from both legume treatments. After the first rainfall simulations, soil NH4+ and NO3– concentrations increased, whereas biomass N concentrations decreased rapidly. Abundance of nirK, nosZ, and AMF was positively correlated (P < 0.05) to N2O emissions. Dynamics and magnitude of emissions after first rainfall events remained similar irrespective of the timing of simulated rainfall. In conclusion, our results indicated that soil incorporation of legumes based on a short‐term rainfall forecast may not be an effective tool to avoid large N2O emissions.
First experience of using valsartan/sacubitril in women with heart failure and breast cancer receiving anthracycline-based adjuvant chemotherapy
Authors: Kanorskiy S. G. , Pavlovets V. P. 
Published: October 2019

Objective. Comparison of the cardioprotective efficacy of valsartan/sacubitril and candesartan in women with heart failure (HF) and an initially reduced left ventricular ejection fraction receiving breast cancer chemotherapy.Material and methods. A prospective study included 112 women aged 53 to 65 years with systolic heart failure, who received surgical treatment for breast cancer followed by adjuvant polychemotherapy according to the FAC scheme (fluorouracil + doxorubicin + cyclophosphamide) - 6 cycles with intervals between 21 days of administration. After randomization, HF therapy with nebivolol, eplerenone, and valsartan/sacubitril (n = 55) or candesartan (n = 57) was performed. A general clinical laboratory study, electrocardiography, daily Holter monitoring of an electrocardiogram, echocardiography, a 6-minute walk test, quality of life assessment were performed initially and repeatedly after 1, 3, and 6 chemotherapy courses.Results. Both groups showed a tendency to troponin I level increase and a significant decrease in the concentration of N-terminal prohormone of brain natriuretic peptide. Only the valsartan/sacubitril group showed a statistically significant increase in the 6-minute walk distance, suppression of ventricular cardiac arrhythmias, improved indicators of systolic function of the left ventricle and quality of life when the Minnesota questionnaire was used.Conclusion. The first randomized trial of valsartan/sacubitril showed superiority compared to candesartan in the treatment of heart failure in women with breast cancer, who received adjuvant chemotherapy, which included anthracycline antibiotic, doxorubicin.
Chronic heart failure: actual aspects of treatment in real clinical practice
Authors: Trukhan D. I. , Davydov E. L. 
Published: October 2019

An urgent public health problem is the optimization of drug therapy in patients with chronic heart failure.A large number of works devoted to the treatment of chronic heart failure form the point of view that about the treatment of chronic heart failure «all is well known for a long time.» However, in real clinical practice, especially at the stage of primary health care, for various reasons, possible pitfalls, reefs and shallows are not taken into account, the underestimation of which can introduce certain difficulties and cause the treatment of patients with chronic heart failure to be ineffective.The review article examined a number of important aspects of the treatment of chronic heart failure, which, for various reasons, are underestimated in the supervision of patients. First of all, this refers to antagonists of mineralocorticoid receptors, in particular to spironolactone, and an inhibitor of If - channels of the sinus node ivabradine.The results of foreign and Russian studies, modern recommendations for the supervision of patients with chronic heart failure, indicate that the presence of spironolactone and ivabradine in the arsenal of a practical doctor allows optimizing drug therapy in patients with chronic heart failure and increasing its effectiveness.
Water supply control system for smarter electricity power usage adopting demand-response scheme
Authors: Tadokoro H. , Koibuchi H. , Takahashi S. , Kakudou S. , Takata Y. , Moriya D. , Sasakawa M. 
Published: October 2019

Abstract
Demand-response is a scheme in which electricity suppliers and consumers collaborate for smarter usage of electricity aiming to mitigate the gap between supply and demand. It makes electricity consumers receive incentives through curtailing or increasing power demand during a certain period subject to request from the power infrastructure. Water utilities, as heavy electricity consumers, could participate in the scheme through shifting power demand by modifying pump operation schedule, utilizing reservoirs' buffering stock capability. We developed a conveyance/transmission pump scheduling algorithm to be applied in the scheme that requires a quick modification of pumping schedule to respond to a request. In addition, we made test bedding through a simulation approach utilizing actual data from Osaka Water Supply Authority to show the scheme's potential for waterworks and the effectiveness of the algorithm.
Risk assessment of floodwater resources utilization in water transfer projects based on an improved cloud model
Authors: Huang Xianfeng , Li Wanyu , Chen Yingqin , Fang Guohua , Yan Wei 
Published: October 2019

Abstract
The utilization of floodwater resources will produce benefits, but it will also pose risks; therefore, it is necessary to strengthen knowledge regarding risk assessment to minimize negative effects. In the present study, the risk factors for the utilization of floodwater resources in water diversion projects were identified, the index system was constructed, and the fuzziness and randomness of the risk were considered. Assessment was performed with respect to the following three projects: water storage, water conveyance, and water pumping. The specific methods to improve the cloud model are as follows: analytic hierarchy process (AHP) is used to calculate subjective weights, entropy weight method and projection pursuit method are used to calculate objective weights, X-conditional cloud is used to calculate index membership degree, and finally combination weight and membership degree are combined to obtain the risk level of flood resource utilization. The above methodology was applied to the risk assessment of floodwater resources utilization in the Jiangsu Province of the East Route of the South-to-North Water Transfer Project. The risk of floodwater resources utilization in high-flow, normal-flow, and low-flow years was evaluated, and the validity and applicability of the assessment method were verified.