bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adiposity measures and their validity in estimating risk of hypertension in South Asian children: a cross-sectional study
Authors: Fowokan Adeleke O , Punthakee Zubin , Waddell Charlotte , Rosin Miriam , Morrison Katherine M , Gupta Milan , Teo Koon , Rangarajan Sumathy , Lear Scott A 
Published: February 2019

ObjectiveGiven the South Asian phenotype of higher body fat at similar body mass index (BMI) relative to Caucasians, we sought to explore the association between prominent adiposity indicators with blood pressure (BP) and hypertension, to compare the accuracy of these indicators in estimating hypertension, and to provide cut-off values associated with adverse hypertension risk in South Asian children.DesignCross-sectional study.SettingCommunity-based recruitment in two Canadian cities (Hamilton and Surrey).ParticipantsSouth Asian children (n=762) were recruited from two Canadian cities. Waist circumference, waist to height ratio and BMI were determined. Body fat percentage was assessed by bioelectrical impedance analysis and BP was assessed using an automated device. All variables (except body fat percentage) were transformed to z-scores using published standards.Outcome measuresLinear and Poisson regression was used to explore associations between the adiposity indicators with BP z-score and hypertension. Receiver operating curve (ROC) analysis was used to explore the strength of the adiposity indicators in estimating hypertension risk and sex-stratified optimal adiposity cut-off values associated with hypertension risk.ResultsSignificant associations were detected in adjusted and unadjusted models between the adiposity indicators with BP z-score and hypertension (p<0.01 for all). The area under the curve (AUC) values for the adiposity indicators for boys and girls ranged from 0.74 to 0.80, suggesting that the adiposity indicators are fair measures of estimating hypertension risk. Sex-stratified cut-off associated with adverse risk of hypertension for girls and boys, respectively, were at the 92nd and 82nd percentile for BMI z-scores, 65th and 80th percentile for WC z-score, 63rd and 67th percentile for WHtR z-score and at 29.8% and 23.5% for body fat.ConclusionOur results show associations between adiposity indicators with BP and hypertension and suggests that South Asian children might be at adverse risk of hypertension at levels of adiposity considered normal.
Impact of patient information leaflets on doctor–patient communication in the context of acute conditions: a prospective, controlled, before–after study in two French emergency departments
Authors: Sustersic Mélanie , Tissot Marisa , Tyrant Julie , Gauchet Aurelie , Foote Alison , Vermorel Céline , Bosson Jean Luc 
Published: February 2019

ObjectiveIn the context of acute conditions seen in an emergency department, where communication may be difficult, patient information leaflets (PILs) could improve doctor–patient communication (DPC) and may have an impact on other outcomes of the consultation. Our objective was to assess the impact of PILs on DPC, patient satisfaction and adherence, and on patient and doctor behaviours.DesignProspective, controlled, before–after trial between November 2013 and June 2015.SettingTwo French emergency departments.ParticipantsAdults and adolescents >15 years diagnosed with ankle sprain or an infection (diverticulitis, infectious colitis, pyelonephritis, pneumonia or prostatitis).InterventionPhysicians in the intervention group gave patients a PIL about their condition along with an oral explanation.Main outcome measures7–10 days later, patients were contacted by phone to answer questionnaires. Results were derived from questions scored using a 4-point Likert scale.Main findingsAnalysis of the 324 patients showed that PILs improved the mean DPC score (range: 13–52), with 46 (42–49) for 168 patients with PILs vs 44 (38-48) for 156 patients without PILs (p<0.01). The adjusted OR for good communication (having a score >35/52) was 2.54 (1.27 to 5.06). The overall satisfaction and adherence scores did not show significant differences. In contrast, satisfaction with healthcare professionals and timing of medication intake were improved with PILs. The overall satisfaction score improved significantly on per-protocol analysis. When using PILs, doctors prescribed fewer drugs and more examinations (radiology, biology, appointment with a specialist); the need for a new medical consultation for the same pathology was reduced from 32.1% to 17.9% (OR 0.46 [0.27 to 0.77]), particularly revisiting the emergency department.ConclusionIn emergency departments, PILs given by doctors improve DPC, increase patients’ satisfaction with healthcare professionals, reduce the number of emergency reconsultations for the same pathology and modify the doctor’s behaviour.Trial registration numberNCT02246361.
Value of antigranulocyte scintigraphy with Tc-99m-sulesomab in diagnosing combat-related infections of the musculoskeletal system
Authors: Loessel Christian , Mai A , Starke M , Vogt D , Stichling M , Willy C 
Published: February 2019

AimCombat-related extremity injuries are regularly associated with long-term complications such as chronic infection, especially osteomyelitis. Clinical examination and laboratory parameters do not usually allow reliable diagnosis. In contrast, imaging techniques enable constructive assertions to be made about the location and extent of an infection of the peripheral musculoskeletal system. The aim of this study was therefore to determine the diagnostic reliability of three-phase bone scanning and antigranulocyte scintigraphy using Tc-99m-sulesomab (Leukoscan) in the diagnostic clarification of infections associated with combat-related extremity injuries.MethodsTwenty-seven male patients (mean age 33.9 years) with suspected combat-associated infections of the extremities were included in this retrospective analysis. All patients underwent three-phase bone scanning using Tc-99m-HDP followed by antigranulocyte scintigraphy with Tc-99m-sulesomab. In 26 of the 27 patients, a CT scan of affected limb was obtained, where the secondary fusion with single photon emission CT data set was possible. The diagnostic reliability of imaging techniques was validated against microbiological samples obtained during surgery and used as gold standard.ResultsThree-phase bone scanning yielded a positive result in all patients, with 18 scans classified as true positive (TP) and nine scans as false positive (FP). This produced a sensitivity of 100%, a specificity of 0% and a positive predictive value (PPV) of 67%. Antigranulocyte scintigraphy recognised 13 patients as TP, 1 patient as FP, 8 patients as true negative (TN) and 5 patients as false negative (FN), which gave a sensitivity of 72%, a specificity of 88%, a PPV of 93%, a negative predictive value (NPV) of 62% and an accuracy of 78%. CT recognised in 7 cases a TP result, in 3 cases an FP, in 5 cases a TN and in 11 cases an FN result. This produced a sensitivity of 39%, a specificity of 63%, a PPV of 70%, an NPV of 31% and an accuracy of 46%.ConclusionsThree-phase bone scanning did not deliver any diagnostic benefit, since no result was able to differentiate unequivocally between infection-related and reactive changes. Antigranulocyte scintigraphy using Tc-99m-sulesomab represented a highly suitable technique for diagnostically clarifying combat-related infections of the extremities. It is superior to CT in sensitivity, specificity, PPV, NPV and accuracy.
Integrability of type 0A matrix model in the presence of D-brane
Authors: Paul Chandrima 
Published: February 2019

We consider type 0A matrix model in the presence of spacelike D-brane which is localized in matter direction at any arbitrary point. In string theory, the boundary state, which in matrix model corresponds to the Laplace transform of the macroscopic loop operator, is known to obey the operator constraints corresponding to open string boundary condition. When we analyze MQM as well as the respective collective field theory and compare it with dual string theory, it appears that consistency of the theory requires a condition equivalent to a constraint on the matter part that needed to be imposed in the matrix model. We identified this condition and observed that this results in constraining the macroscopic loop operator so that it projects the Hilbert space generated by the operator to its physical sector at the point of insertion while keeping the bulk matrix model unaffected, thereby describing a situation parallel to string theory. We analyzed the theory with uncompactified time and have shown explicitly that the matrix model predictions are in good agreement with the relevant string theory. Next, we considered the theory with compactified time, analyzed MQM on a circle in the presence of D-brane. We evaluated the partition function along with the constrained macroscopic loop operator in the grand canonical ensemble and showed the free energy corresponds to that of a deformed Fermi surface. We have also shown that the path integral in the presence of D-brane can be expressed as the Fredholm determinant. We have studied the fermionic scattering in a semiclassical regime. Finally, we considered the compactified theory in the presence of the D-brane with tachyonic background. We evaluated the free energy in the grand canonical ensemble. We have shown the integrable structure of the respective partition function and it corresponds to the tau function of Toda hierarchy. We have also analyzed the dispersionless limit.
Volitional control of single-electrode high gamma local field potentials by people with paralysis
Authors: Milekovic Tomislav , Bacher Daniel , Sarma Anish A. , Simeral John D. , Saab Jad , Pandarinath Chethan , Yvert Blaise , Sorice Brittany L. , Blabe Christine , Oakley Erin M. , Tringale Kathryn R. , Eskandar Emad , Cash Sydney S. , Shenoy Krishna V. , Henderson Jaimie M. , Hochberg Leigh R. , Donoghue John P. 
Published: February 2019

Intracortical brain-computer interfaces (BCIs) can enable individuals to control effectors, such as a computer cursor, by directly decoding the user’s movement intentions from action potentials and local field potentials (LFPs) recorded within the motor cortex. However, the accuracy and complexity of effector control achieved with such “biomimetic” BCIs will depend on the degree to which the intended movements used to elicit control modulate the neural activity. In particular, channels that do not record distinguishable action potentials and only record LFP modulations may be of limited use for BCI control. In contrast, a biofeedback approach may surpass these limitations by letting the participants generate new control signals and learn strategies that improve the volitional control of signals used for effector control. Here, we show that, by using a biofeedback paradigm, three individuals with tetraplegia achieved volitional control of gamma LFPs (40–400 Hz) recorded by a single microelectrode implanted in the precentral gyrus. Control was improved over a pair of consecutive sessions up to 3 days apart. In all but one session, the channel used to achieve control lacked distinguishable action potentials. Our results indicate that biofeedback LFP-based BCIs may potentially contribute to the neural modulation necessary to obtain reliable and useful control of effectors. NEW & NOTEWORTHY Our study demonstrates that people with tetraplegia can volitionally control individual high-gamma local-field potential (LFP) channels recorded from the motor cortex, and that this control can be improved using biofeedback. Motor cortical LFP signals are thought to be both informative and stable intracortical signals and, thus, of importance for future brain-computer interfaces.
Discriminating between anticipatory and visually triggered saccades: measuring minimal visual saccadic response time using luminance
Authors: Heeman Jessica , Van der Stigchel Stefan , Munoz Douglas P. , Theeuwes Jan 
Published: February 2019

We describe a novel behavioral method to accurately discriminate anticipatory (i.e., saccades not generated by visual input) from visually triggered saccades and to identify the minimal visual saccadic reaction time (SRT). This method can be used to calculate a feasible lower bound cutoff for latencies of visually triggered saccades within a certain experimental context or participant group. We apply this method to compute the minimal visual SRT for two different saccade target luminance levels. Three main findings are presented: 1) the minimal visual SRT for all participants was 46 ms shorter for bright targets than for dim targets, 2) the transition from non-visually triggered to visually triggered saccades occurred abruptly, independent of target luminance, and 3) although the absolute minimal visual SRTs varied between participants, the response pattern (response to bright targets being faster than to dim targets) was consistent across participants. These results are consistent with variability in saccadic and neural responses to luminance as has been reported in monkeys. On the basis of these results, we argue that differences in the minimal visual SRT can easily occur when stimuli vary in luminance or other saliency features. Applying an absolute cutoff (i.e., 70–90 ms) that approaches the minimal neuronal conduction delays, which is general practice in many laboratories, may result in the wrongful inclusion of saccades that are not visually triggered. It is suggested to assess the lower SRT bound for visually triggered saccades when piloting an experimental setup and before including saccades based on particular latency criteria. NEW & NOTEWORTHY We successfully developed an anticipation paradigm to discriminate between anticipatory and visually triggered saccades by measuring the minimal visual saccadic response time (SRT). We show that the 70- to 90-ms lower bound cutoff for visually triggered saccades should be applied in a flexible way and that the transitional interval is very short. The paradigm can be employed to investigate the effects of different stimulus features, experimental conditions, and participant groups on the minimal visual SRT in humans.
Increased preparation time reduces, but does not abolish, action history bias of saccadic eye movements
Authors: Reuter Eva-Maria , Marinovic Welber , Welsh Timothy N. , Carroll Timothy J. 
Published: February 2019

The characteristics of movements are strongly history-dependent. Marinovic et al. (Marinovic W, Poh E, de Rugy A, Carroll TJ. eLife 6: e26713, 2017) showed that past experience influences the execution of limb movements through a combination of temporally stable processes that are strictly use dependent and dynamically evolving and context-dependent processes that reflect prediction of future actions. Here we tested the basis of history-dependent biases for multiple spatiotemporal features of saccadic eye movements under two preparation time conditions (long and short). Twenty people performed saccades to visual targets. To prompt context-specific expectations of most likely target locations, 1 of 12 potential target locations was specified on ~85% of the trials and each remaining target was presented on ~1% trials. In long preparation trials participants were shown the location of the next target 1 s before its presentation onset, whereas in short preparation trials each target was first specified as the cue to move. Saccade reaction times and direction were biased by recent saccade history but according to distinct spatial tuning profiles. Biases were purely expectation related for saccadic reaction times, which increased linearly as the distance from the repeated target location increased when preparation time was short but were similar to all targets when preparation time was long. By contrast, the directions of saccades were biased toward the repeated target in both preparation time conditions, although to a lesser extent when the target location was precued (long preparation). The results suggest that saccade history affects saccade dynamics via both use- and expectation-dependent mechanisms and that movement history has dissociable effects on reaction time and saccadic direction. NEW & NOTEWORTHY The characteristics of our movements are influenced not only by concurrent sensory inputs but also by how we have moved in the past. For limb movements, history effects involve both use-dependent processes due strictly to movement repetition and processes that reflect prediction of future actions. Here we show that saccade history also affects saccade dynamics via use- and expectation-dependent mechanisms but that movement history has dissociable effects on saccade reaction time and direction.
lnCAR: A Comprehensive Resource for lncRNAs from Cancer Arrays
Authors: Zheng Yueyuan , Xu Qingxian , Liu Mengni , Hu Huanjing , Xie Yubin , Zuo Zhixiang , Ren Jian 
Published: February 2019

Abstract

Long noncoding RNAs (lncRNA) have emerged as promising biomarkers in cancer diagnosis, treatment, and prognosis. Recent studies suggest that a large number of coding gene expression microarray probes could be reannotated as lncRNAs. Microarray, once the most cutting-edge high-throughput gene expression technology, has been used for thousands of cancer studies and has brought invaluable resources for studying the functions of lncRNA in cancer development. However, a comprehensive lncRNA resource based on microarray data is still lacking. Here, we present lnCAR (lncRNAs from cancer arrays), a comprehensive open resource for providing expression profiles and prognostic landscape of lncRNAs derived from reannotation of public microarray data. Currently, lnCAR contains 52,300 samples for differential expression analysis and 12,883 samples for survival analysis from 10 cancer types. lnCAR allows users to interactively explore any annotated or novel lncRNAs. We believe lnCAR will serve as a valuable resource for the community focused on lncRNA research in cancer.

Significance:
lnCAR, a new interactive tool of reannotated public cancer-related microarray data, provides expression profiles and prognostic landscapes of lncRNAs across thousands of samples and multiple cancer types.
Genetic Ancestry Analysis Reveals Misclassification of Commonly Used Cancer Cell Lines
Authors: Hooker Stanley E. , Woods-Burnham Leanne , Bathina Madhavi , Lloyd Stacy , Gorjala Priyatham , Mitra Ranjana , Nonn Larisa , Kimbro K. Sean , Kittles Rick A. 
Published: February 2019

Abstract

Background:
Given the scarcity of cell lines from underrepresented populations, it is imperative that genetic ancestry for these cell lines is characterized. Consequences of cell line mischaracterization include squandered resources and publication retractions.

Methods:
We calculated genetic ancestry proportions for 15 cell lines to assess the accuracy of previous race/ethnicity classification and determine previously unknown estimates. DNA was extracted from cell lines and genotyped for ancestry informative markers representing West African (WA), Native American (NA), and European (EUR) ancestry.

Results:
Of the cell lines tested, all previously classified as White/Caucasian were accurately described with mean EUR ancestry proportions of 97%. Cell lines previously classified as Black/African American were not always accurately described. For instance, the 22Rv1 prostate cancer cell line was recently found to carry mixed genetic ancestry using a much smaller panel of markers. However, our more comprehensive analysis determined the 22Rv1 cell line carries 99% EUR ancestry. Most notably, the E006AA-hT prostate cancer cell line, classified as African American, was found to carry 92% EUR ancestry. We also determined the MDA-MB-468 breast cancer cell line carries 23% NA ancestry, suggesting possible Afro-Hispanic/Latina ancestry.

Conclusions:
Our results suggest predominantly EUR ancestry for the White/Caucasian-designated cell lines, yet high variance in ancestry for the Black/African American–designated cell lines. In addition, we revealed an extreme misclassification of the E006AA-hT cell line.

Impact:
Genetic ancestry estimates offer more sophisticated characterization leading to better contextualization of findings. Ancestry estimates should be provided for all cell lines to avoid erroneous conclusions in disparities literature.
Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases
Authors: Fischer Grant M. , Jalali Ali , Kircher David A. , Lee Won-Chul , McQuade Jennifer L. , Haydu Lauren E. , Joon Aron Y. , Reuben Alexandre , de Macedo Mariana P. , Carapeto Fernando C. L. , Yang Chendong , Srivastava Anuj , Ambati Chandrashekar R. , Sreekumar Arun , Hudgens Courtney W. , Knighton Barbara , Deng Wanleng , Ferguson Sherise D. , Tawbi Hussein A. , Glitza Isabella C. , Gershenwald Jeffrey E. , Vashisht Gopal Y. N. , Hwu Patrick , Huse Jason T. , Wargo Jennifer A. , Futreal P. Andrew , Putluri Nagireddy , Lazar Alexander J. , DeBerardinis Ralph J. , Marszalek Joseph R. , Zhang Jianjun , Holmen Sheri L. , Tetzlaff Michael T. , Davies Michael A. 
Published: February 2019

Abstract

There is a critical need to improve our understanding of the pathogenesis of melanoma brain metastases (MBM). Thus, we performed RNA sequencing on 88 resected MBMs and 42 patient-matched extracranial metastases; tumors with sufficient tissue also underwent whole-exome sequencing, T-cell receptor sequencing, and IHC. MBMs demonstrated heterogeneity of immune infiltrates that correlated with prior radiation and post-craniotomy survival. Comparison with patient-matched extracranial metastases identified significant immunosuppression and enrichment of oxidative phosphorylation (OXPHOS) in MBMs. Gene-expression analysis of intracranial and subcutaneous xenografts, and a spontaneous MBM model, confirmed increased OXPHOS gene expression in MBMs, which was also detected by direct metabolite profiling and [U-13C]-glucose tracing in vivo. IACS-010759, an OXPHOS inhibitor currently in early-phase clinical trials, improved survival of mice bearing MAPK inhibitor–resistant intracranial melanoma xenografts and inhibited MBM formation in the spontaneous MBM model. The results provide new insights into the pathogenesis and therapeutic resistance of MBMs.

Significance:
Improving our understanding of the pathogenesis of MBMs will facilitate the rational development and prioritization of new therapeutic strategies. This study reports the most comprehensive molecular profiling of patient-matched MBMs and extracranial metastases to date. The data provide new insights into MBM biology and therapeutic resistance.
See related commentary by Egelston and Margolin, p. 581.
This article is highlighted in the In This Issue feature, p. 565
Lifeforms as criterion for species delimitation: Are Aristida adscensionis and A. coerulescens (Aristidoideae, Poaceae) two species?
Authors: THIV MIKE , REYES-BETANCORT J. ALFREDO , FRAGMAN-SAPIR ORI 
Published: February 2019

The distinction of the perennial Aristida coerulescens from the annual A. adscensionis and its taxonomic treatment has been subject of long discussions. We here include accessions from the Mediterranean and Macaronesia for molecular phylogenetic analyses and conducted a morphometric analysis. A lineage of A. adscensionis, A. coerulescens and A. effusa is well supported in phylogenetic trees. Moreover, a group of Mediterranean, Macaronesia and Arabian A. coerulescens and A. adscensionis is revealed where both taxa are intermingled. A morphological analysis of traditionally used spikelet characters did not indicate a clear separation of both taxa. We therefore conclude that A. coerulescens should best be treated as synonym of A. adscensionis. The differential character of annual and perennial life forms seems to be plastic in this taxon indicating rapid shifts between these two strategies.
The Ghost of Crises Past: A Reply to Mooi and Gill
Authors: CRAIG MATTHEW T. 
Published: February 2019

The conclusion one might draw from all this is that the criterion used to define homology – i.e., the criterion of common ancestry – is a theoretical construct. Like truth, we must approximate it as best we can, and we have no touchstone to tell whether we have found it.---Colin Patterson, 1988: 621