bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-assembled Collagen-Fibrin Hydrogel Reinforces Tissue Engineered Adventitia Vessels Seeded with Human Fibroblasts
Authors: Patel Bijal , Xu Zhengfan , Pinnock Cameron B. , Kabbani Loay S. , Lam Mai T. 
Published: February 2018

AbstractEfforts for tissue engineering vascular grafts focuses on the tunica media and intima, although the tunica adventitia serves as the primary structural support for blood vessels. In surgery, during endarterectomies, surgeons can strip the vessel, leaving the adventitia as the main strength layer to close the vessel. Here, we adapted our recently developed technique of forming vascular tissue rings then stacking the rings into a tubular structure, to accommodate human fibroblasts to create adventitia vessels in 8 days. Collagen production and fibril cross-linking was augmented with TGF-β and ascorbic acid, significantly increasing tensile strength to 57.8 ± 3.07 kPa (p = 0.008). Collagen type I gel was added to the base fibrin hydrogel to further increase strength. Groups were: Fibrin only; 0.7 mg/ml COL; 1.7 mg/ml COL; and 2.2 mg/ml COL. The 0.7 mg/ml collagen rings resulted in the highest tensile strength at 77.0 ± 18.1 kPa (p = 0.015). Culture periods of 1–2 weeks resulted in an increase in extracellular matrix deposition and significantly higher failure strength but not ultimate tensile strength. Histological analysis showed the 0.7 mg/ml COL group had significantly more, mature collagen. Thus, a hydrogel of 0.7 mg/ml collagen in fibrin was ideal for creating and strengthening engineered adventitia vessels.
Photoconductivity of acid exfoliated and flash-light-processed MoS2 films
Authors: Zhang Renyun , Hummelgård Magnus , Forsberg Viviane , Andersson Henrik , Engholm Magnus , Öhlund Thomas , Olsen Martin , Örtegren Jonas , Olin Håkan 
Published: February 2018

AbstractMoS2 has been studied intensively during recent years as a semiconducting material in several fields, including optoelectronics, for applications such as solar cells and phototransistors. The photoresponse mechanisms of MoS2 have been discussed but are not fully understood, especially the phenomenon in which the photocurrent slowly increases. Here, we report on a study of the photoresponse flash-light-processed MoS2 films of different thicknesses and areas. The photoresponse of such films under different light intensities and bias voltages was measured, showing significant current changes with a quick response followed by a slow one upon exposure to pulsed light. Our in-depth study suggested that the slow response was due to the photothermal effect that heats the MoS2; this hypothesis was supported by the resistivity change at different temperatures. The results obtained from MoS2 films with various thicknesses indicated that the minority-carrier diffusion length was 1.36 µm. This study explained the mechanism of the slow response of the MoS2 film and determined the effective thickness of MoS2 for a photoresponse to occur. The method used here for fabricating MoS2 films could be used for fabricating optoelectronic devices due to its simplicity.
Identification of novel prognosis-related genes associated with cancer using integrative network analysis
Authors: Wee YongKiat , Liu Yining , Lu Jiachun , Li Xiaoyan , Zhao Min 
Published: February 2018

AbstractPrognosis identifies the seriousness and the chances of survival of a cancer patient. However, it remains a challenge to identify the key cancer genes in prognostic studies. In this study, we collected 2064 genes that were related to prognostic studies by using gene expression measurements curated from published literatures. Among them, 1820 genes were associated with copy number variations (CNVs). The further functional enrichment on 889 genes with frequent copy number gains (CNGs) revealed that these genes were significantly associated with cancer pathways including regulation of cell cycle, cell differentiation and mitogen-activated protein kinase (MAPK) cascade. We further conducted integrative analyses of CNV and their target genes expression using the data from matched tumour samples of The Cancer Genome Atlas (TCGA). Ultimately, 95 key prognosis-related genes were extracted, with concordant CNG events and increased up-regulation in at least 300 tumour samples. These genes, and the number of samples in which they were found, included: ACTL6A (399), ATP6V1C1 (425), EBAG9 (412), FADD (308), MTDH (377), and SENP5 (304). This study provides the first observation of CNV in prognosis-related genes across pan-cancer. The systematic concordance between CNG and up-regulation of gene expression in these novel prognosis-related genes may indicate their prognostic significance.
High sensitization efficiency and energy transfer routes for population inversion at low pump intensity in Er organic complexes for IR amplification
Authors: Hu J. X. , Karamshuk S. , Gorbaciova J. , Ye H. Q. , Lu H. , Zhang Y. P. , Zheng Y. X. , Liang X. , Hernández I. , Wyatt P. B. , Gillin W. P. 
Published: February 2018

AbstractOrganic erbium complexes have long been of interest due to their potential for using the strong absorption into the organic to sensitise the erbium emission. Despite this interest there is remarkably little quantitative information on how effective the approach is and the discussion of the energy transfer mechanism is generally vague. Here we accurately quantify the sensitisation as a function of excitation pump density and model it using a rate equation approach. As a result, we can calculate the degree of population inversion for the erbium ions as a function of the pump intensity. We demonstrate that even when we increase the erbium concentration in the films from ~10 to ~80% we find a relatively small decrease in the sensitisation which we attribute to the large (>20 Å) Förster radius for the sensitisation process. We show that we can obtain population inversion in our films at very low pump powers ~600 mW/cm2. The calculated Förster radius for the organic erbium complexes suggests design rules for energy transfer between antennas and erbium ions in molecular systems and hybrid organic-inorganic nanoparticles.
Self-calibrating d-scan: measuring ultrashort laser pulses on-target using an arbitrary pulse compressor
Authors: Alonso Benjamín , Sola Íñigo J. , Crespo Helder 
Published: February 2018

AbstractIn most applications of ultrashort pulse lasers, temporal compressors are used to achieve a desired pulse duration in a target or sample, and precise temporal characterization is important. The dispersion-scan (d-scan) pulse characterization technique usually involves using glass wedges to impart variable, well-defined amounts of dispersion to the pulses, while measuring the spectrum of a nonlinear signal produced by those pulses. This works very well for broadband few-cycle pulses, but longer, narrower bandwidth pulses are much more difficult to measure this way. Here we demonstrate the concept of self-calibrating d-scan, which extends the applicability of the d-scan technique to pulses of arbitrary duration, enabling their complete measurement without prior knowledge of the introduced dispersion. In particular, we show that the pulse compressors already employed in chirped pulse amplification (CPA) systems can be used to simultaneously compress and measure the temporal profile of the output pulses on-target in a simple way, without the need of additional diagnostics or calibrations, while at the same time calibrating the often-unknown differential dispersion of the compressor itself. We demonstrate the technique through simulations and experiments under known conditions. Finally, we apply it to the measurement and compression of 27.5 fs pulses from a CPA laser.
Imaging genotyping of functional signaling pathways in lung squamous cell carcinoma using a radiomics approach
Authors: Bak So Hyeon , Park Hyunjin , Lee Ho Yun , Kim Youngwook , Kim Hyung-Lae , Jung Sin-Ho , Kim Hyeseung , Kim Jonghoon , Park Keunchil 
Published: February 2018

AbstractImaging features can be useful for identifying distinct genomic differences and have predictive power for certain phenotypes attributed to genomic mutations. We aimed to identify predictive imaging biomarkers that underpin genomic alterations and clinical outcomes in lung squamous cell carcinoma (SQCC) using a radiomics approach. In 57 patients with lung SQCC who underwent preoperative computed tomography (CT) and whole-exome DNA sequencing, 63 quantitative imaging features were extracted from CT and 73 clinicoradiological features including imaging features were classified into 8 categories: clinical, global, histogram-based, lung cancer-specific, shape, local, regional, and emphysema. Mutational profiles for core signaling pathways of lung SQCC were classified into five categories: redox stress, apoptosis, proliferation, differentiation, and chromatin remodelers. Range and right lung volume was significantly associated with alternation of apoptosis and proliferation pathway (p = 0.03, and p = 0.03). Energy was associated with the redox stress pathway (p = 0.06). None of the clinicoradiological features showed any significant association with the alteration of differentiation and chromatin remodelers pathway. This study showed that radiomic features indicating five different functional pathways of lung SQCC were different form one another. Radiomics approaches to lung SQCC have the potential to noninvasively predict alterations in core signaling pathways and clinical outcome.
Relevance of electrical current distribution to the forced flow and grain refinement in solidified Al-Si hypoeutectic alloy
Authors: Zhang Y. H. , Xu Y. Y. , Ye C. Y. , Sheng C. , Sun J. , Wang G. , Miao X. C. , Song C. J. , Zhai Q. J. 
Published: February 2018

AbstractSignificant grain refinement in cast metals can be achieved through the application of electric currents during the solidification process. The present paper investigates the distribution of electric currents on the grain size of solidified Al-7wt.%Si alloy under the application of electric current with constant parameters flowing through two parallel electrodes into the melt within a cylindrical mould. The distribution of electric current was controlled by applying an electrical insulation material coating, boron nitride (NB), to the sidewall of the electrodes. Experimental results showed that the employment of these insulated electrodes can reduce grain size in comparison with the reference case of electrodes without BN coating. Flow measurements were performed in Ga-20wt.%In-12wt.%Sn liquid metal. Higher intensity forced flow occurred when the sidewall of the electrodes was insulated. In order to understand the underlying mechanism behind the stronger forced flow, corresponding numerical simulations were performed to reveal the distributions of the electric current, magnetic field, Lorentz force, and the resultant forced flow. The results achieved indicate that the mechanism of grain refinement driven by electric current is dendrite fragmentation induced by forced flow. In addition, a novel approach to enhance the grain refinement without additional input of current energy was developed.
Reversible 90-Degree Rotation of Fe Magnetic Moment Using Hydrogen
Authors: Hsu Chuan-Che , Chang Po-Chun , Chen Yi-Hua , Liu Chak-Ming , Wu Chun-Te , Yen Hung-Wei , Lin Wen-Chin 
Published: February 2018

Abstract[Pd/Fe]2 multilayers were deposited on a flat MgO(001) to study the effect of hydrogen on magnetic interlayer coupling. Complex magnetic hysteresis behavior, including single, double, and triple loops, were measured as a function of the azimuthal angle in a longitudinal and transverse direction. With a combination of a 2-fold magnetic anisotropy energy (MAE) in the bottom-Fe and a 4-fold MAE in the top-Fe, the complex magnetic hysteresis behavior could be clearly explained. Two well-split hysteresis loops with almost zero Kerr remanence were measured by choosing a suitable Pd thickness and applying the magnetic field perpendicular to the easy axis of the bottom-Fe. The split double loops originated from the 90°-rotation of the top-Fe moment. On exposure to a hydrogen gas atmosphere, the separation of the two minor loops increased, indicating that Pd-hydride formation enhanced the ferromagnetic coupling between the two Fe layers. Based on these observations, we proposed that, by applying a suitable constant magnetic field, the top-Fe moment could undergo reversible 90°-rotation following hydrogen exposure. The results suggest that the Pd space layer used for mediating the magnetic interlayer coupling is sensitive to hydrogen, and therefore, the multilayer system can function as a giant magnetoresistance-type sensor suitable for hydrogen gas.
Nonylphenol aggravates non-alcoholic fatty liver disease in high sucrose-high fat diet-treated rats
Authors: Yu Jie , Yang Xuesong , Yang Xuefeng , Yang Mengxue , Wang Pan , Yang Yu , Yang Jing , Li Wenmei , Xu Jie 
Published: February 2018

AbstractExposure to environmental endocrine disruptors (EEDs) contributes to the pathogenesis of many metabolic disorders. Here, we have analyzed the effect of the EED-nonylphenol (NP) on the promotion of non-alcoholic fatty liver disease (NAFLD) in rats fed high sucrose-high fat diet (HSHFD). Fifty Sprague-Dawley rats were divided into five groups: controls fed a normal diet (C-ND); HSHFD-fed controls (C-HSHFD); and rats fed a HSHFD combined with NP at doses of 0.02 μg/kg/day (NP-L-HSHFD), 0.2 μg/kg/day (NP-M-HSHFD), and 2 μg/kg/day (NP-H-HSHFD). Subchronic exposure to NP coupled with HSHFD increased daily water and food intake (p < 0.05), hepatic echogenicity and oblique liver diameter (p < 0.05), and plasma levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglycerides, and low density lipoprotein cholesterol (p < 0.05). Combined exposure to NP and HSHFD induced macrovesicular steatosis with dilation and congestion of the central vein, liver inflammatory cell infiltration, and expression of genes regulating lipid metabolism, SREBP-1C, FAS, and Ucp2. These results demonstrate that NP aggravates NAFLD in HSHFD-treated rats by up-regulating lipogenic genes, and that HSHFD increases the toxic effects of NP. Thus subchronic NP exposure may lead to NAFLD, especially when combined with a high-sucrose/high-fat diet.
Dataset of human medial temporal lobe single neuron activity during declarative memory encoding and recognition
Authors: Faraut Mailys C. M. , Carlson April A. , Sullivan Shannon , Tudusciuc Oana , Ross Ian , Reed Chrystal M. , Chung Jeffrey M. , Mamelak Adam N , Rutishauser Ueli 
Published: February 2018

AbstractWe present a dataset of 1,576 single neurons recorded from the human amygdala and hippocampus in 65 sessions from 42 patients undergoing intracranial monitoring for localization of epileptic seizures. Subjects performed a recognition memory task with pictures as stimuli. Subjects were asked to identify whether they had seen a particular image the first time (‘new’) or second time (‘old’) on a 1–6 confidence scale. This comprehensive dataset includes the spike times of all neurons and their extracellular waveforms, behavior, electrode locations determined from post-operative MRI scans, demographics, and the stimuli shown. As technical validation, we provide spike sorting quality metrics and assessment of tuning of cells to verify the presence of visually-and memory selective cells. We also provide analysis code that reproduces key scientific findings published previously on a smaller version of this dataset. Together, this large dataset will facilitate the investigation of the neural mechanism of declarative memory by providing a substantial number of hard to obtain human single-neuron recordings during a well characterized behavioral task.
Single cell RNA sequencing of stem cell-derived retinal ganglion cells
Authors: Daniszewski Maciej , Senabouth Anne , Nguyen Quan H. , Crombie Duncan E. , Lukowski Samuel W. , Kulkarni Tejal , Sluch Valentin M. , Jabbari Jafar S. , Chamling Xitiz , Zack Donald J. , Pébay Alice , Powell Joseph E. , Hewitt Alex W. 
Published: February 2018

AbstractWe used single cell sequencing technology to characterize the transcriptomes of 1,174 human embryonic stem cell-derived retinal ganglion cells (RGCs) at the single cell level. The human embryonic stem cell line BRN3B-mCherry (A81-H7), was differentiated to RGCs using a guided differentiation approach. Cells were harvested at day 36 and prepared for single cell RNA sequencing. Our data indicates the presence of three distinct subpopulations of cells, with various degrees of maturity. One cluster of 288 cells showed increased expression of genes involved in axon guidance together with semaphorin interactions, cell-extracellular matrix interactions and ECM proteoglycans, suggestive of a more mature RGC phenotype.
The Brain/MINDS 3D digital marmoset brain atlas
Authors: Woodward Alexander , Hashikawa Tsutomu , Maeda Masahide , Kaneko Takaaki , Hikishima Keigo , Iriki Atsushi , Okano Hideyuki , Yamaguchi Yoko 
Published: February 2018

AbstractWe present a new 3D digital brain atlas of the non-human primate, common marmoset monkey (Callithrix jacchus), with MRI and coregistered Nissl histology data. To the best of our knowledge this is the first comprehensive digital 3D brain atlas of the common marmoset having normalized multi-modal data, cortical and sub-cortical segmentation, and in a common file format (NIfTI). The atlas can be registered to new data, is useful for connectomics, functional studies, simulation and as a reference. The atlas was based on previously published work but we provide several critical improvements to make this release valuable for researchers. Nissl histology images were processed to remove illumination and shape artifacts and then normalized to the MRI data. Brain region segmentation is provided for both hemispheres. The data is in the NIfTI format making it easy to integrate into neuroscience pipelines, whereas the previous atlas was in an inaccessible file format. We also provide cortical, mid-cortical and white matter boundary segmentations useful for visualization and analysis.
Calibrated 10 b 28 nm CMOS SAR ADC based on integer‐based split capacitors
Authors: Lee E.‐C. , An T.‐J. , Park J.‐S. , Ahn G.‐C. , Lee S.‐H. 
Published: February 2018

A calibrated 10 b 5 MS/s 28 nm CMOS successive‐approximation‐register ADC based on an integer‐based split capacitor array is presented. The proposed ADC employs a split capacitor array to optimise the overall power consumption, chip area and linearity performance. An attenuation capacitor between two capacitor arrays is implemented with an integer multiple of unit capacitors rather than a fraction of unit capacitors. The proposed calibration of capacitors reduces the non‐linearity error caused by device mismatches in the conventional split capacitor array. The measured prototype ADC which has an active die area of 0.063 mm2 shows a maximum signal‐to‐noise‐and‐distortion ratio and spurious‐free dynamic range of 59.25 and 70.44 dB, respectively, and consumes 42.5 μW at 0.7 V and 5 MS/s. Moreover, the measured differential non‐linearity (NL) and integral NL are within 0.36 and 0.52 least significant bit, respectively, after calibration.
Millimetre‐wave high‐gain circularly polarised SIW end‐fire bow‐tie antenna by utilising semi‐planar helix unit cell
Authors: Rafiei V. , Karamzadeh S. , Saygin H. 
Published: February 2018

In this work, a high‐gain circularly polarised (CP) substrate integrated waveguide (SIW) bow‐tie antenna is presented. The proposed antenna includes a pair of bow‐tie radiators. To centralisation radiated pattern and recede side lobe and back lobe level two tilted rows of metalised via hole at the end of the SIW feed line is used. The methods of increasing the antenna gain and generating the CP are discussed. The proposed antenna was fabricated to validate simulated results. The designed structure operates across 40–68 GHz and exhibits a gain of 10–12.5 dBic. In addition, the proposed antenna exhibits a 3‐dB axial ratio bandwidth from 54 to 64.3 GHz.
Microstrip differential passband filter with high common‐mode suppression using periodically loaded stubs and coupled resonators
Authors: Attar Amir , Joodaki Mojtaba 
Published: February 2018

In this study, a periodic structure as a passband filter for differential input signals is introduced that suppresses the common‐mode noise with a high common‐mode rejection ratio on a wide range of frequencies. The unit cell of the periodic structure consists of open‐ended stubs under common‐mode and short‐ended stubs under differential‐mode excitation. The proposed design procedure introduced in this paper can be exploited for different microwave frequency bands while the overall shape of the filter remains unchanged. To verify the design approach, the authors designed and fabricated a filter at the centre frequency of 7 GHz on a Rogers RO4003 substrate with a dielectric constant of 3.7 and a loss tangent of 0.0027. Their studies show that for a three‐unit‐cell structure with the overall size of 18 mm × 40 mm (0.75λ g × 1.66λ g), a differential fractional bandwidth of 8.6% and a rejection ratio over 55 dB are achieved while the differential in band insertion loss is around 2 dB.
Oceanic tides from Earth-like to ocean planets
Authors: Auclair-Desrotour P. , Mathis S. , Laskar J. , Leconte J. 
Published: February 2018

Context.Oceanic tides are a major source of tidal dissipation. They drive the evolution of planetary systems and the rotational dynamics of planets. However, two-dimensional (2D) models commonly used for the Earth cannot be applied to extrasolar telluric planets hosting potentially deep oceans because they ignore the three-dimensional (3D) effects related to the ocean’s vertical structure.Aims.Our goal is to investigate, in a consistant way, the importance of the contribution of internal gravity waves in the oceanic tidal response and to propose a modelling that allows one to treat a wide range of cases from shallow to deep oceans.Methods.A 3D ab initio model is developed to study the dynamics of a global planetary ocean. This model takes into account compressibility, stratification, and sphericity terms, which are usually ignored in 2D approaches. An analytic solution is computed and used to study the dependence of the tidal response on the tidal frequency and on the ocean depth and stratification.Results.In the 2D asymptotic limit, we recover the frequency-resonant behaviour due to surface inertial-gravity waves identified by early studies. As the ocean depth and Brunt–Väisälä frequency increase, the contribution of internal gravity waves grows in importance and the tidal response becomes 3D. In the case of deep oceans, the stable stratification induces resonances that can increase the tidal dissipation rate by several orders of magnitude. It is thus able to significantly affect the evolution time scale of the planetary rotation.