bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antecedents and Consequences of Eco‐Control Deployment: Evidence from Canadian Manufacturing Firms
Authors: Henri Jean‐François , Journeault Marc 
Published: August 2018

AbstractEnvironmental issues have become an important consideration for a growing number of organizations. Eco‐control may represent a valuable tool to help organizations address such issues. The aim of this study is to provide an overview of the eco‐control practices adopted by Canadian organizations and to understand the antecedents and consequences of their adoption. More specifically, this study examines (i) the extent to which eco‐control practices are deployed within organizations, (ii) the factors and motivations that lead organizations to implement eco‐control practices, and (iii) the impact of adoption on firms’ managerial and operational environmental actions as well as on environmental and economic performance. Using survey data from a sample of 249 Canadian manufacturing firms, this article shows that environmental missions, environmental policies, environmental strategic planning, environmental budgets and environmental performance indicators are the most frequently adopted eco‐control practices among the investigated firms, while environmental incentives seem to be less frequently adopted. The results of this study also suggest that competitive and ethical motivations as well as size, environmental exposure and stakeholder pressure are all important factors in explaining eco‐control practice adoption by Canadian manufacturing firms. Moreover, the results of this study show that organizations that have undertaken more intensive managerial and operational environmental actions have also adopted more intensive eco‐control practices. Organizations adopting more intensive eco‐control practices perform better both environmentally and economically performance than firms adopting less intensive eco‐control practices.
Prevalence and prediction of higher estimated gastric content in parturients at full cervical dilatation: A prospective cohort study
Authors: Desgranges François‐Pierrick , Simonin Marine , Barnoud Sophie , Zieleskiewicz Laurent , Cercueil Eloise , Erbacher Julien , Allaouchiche Bernard , Chassard Dominique , Bouvet Lionel 
Published: August 2018

BackgroundEmergent obstetrical procedures may require general anaesthesia in parturients at full cervical dilatation or immediately after vaginal birth. This study aimed to determine the prevalence and the predictive factors of higher estimated gastric content in parturients at full cervical dilatation with epidural analgesia and allowed to drink during the labour, and to assess the ability of the antral area measured in the semirecumbent position (SR‐CSA) to identify higher estimated gastric content in this setting.MethodsThis prospective observational study was conducted between December 2016 and July 2017. Ultrasonographic examination of the antrum was performed at full cervical dilatation, within the hour preceding the beginning of expulsive efforts. Higher estimated gastric content was defined when solid content was observed and/or if the calculated gastric fluid volume was >1.5 mL/kg.ResultsSeventeen of 62 parturients (27%) presented higher estimated gastric content. Maximal pain intensity during the last hour of labour and time interval between the insertion of the epidural catheter and ultrasonographic examination were significantly increased in parturients with higher estimated gastric content. The threshold value of the SR‐CSA to identify a higher estimated gastric content was 393 mm2, with sensitivity = 88% and specificity = 87%.ConclusionAround a quarter of parturients with epidural analgesia and free access to clear fluids during labour presented higher estimated gastric content at full cervical dilatation. The SR‐CSA may be of interest for the fast ultrasound assessment of the gastric content status in case of emergent obstetrical procedures at full cervical dilatation.
Elevated serum S‐100β in patients with septic shock is associated with delirium
Authors: Erikson Kristo , Ala‐Kokko Tero Ilmari , Koskenkari Juha , Liisanantti Janne Henrik , Kamakura Remi , Herzig Karl Heinz , Syrjälä Hannu 
Published: August 2018

BackgroundA high prevalence of delirium is observed in sepsis, yet specific markers for this brain dysfunction in sedated patients are still lacking. Cytoplasmic low molecular weight calcium‐binding protein, S‐100β, is a commonly used nonspecific marker for brain injury. Here, we evaluated whether delirium is associated with increases in S‐100β levels.MethodsThis observational study included 22 patients with septic shock. Delirium was assessed by CAM‐ICU and blood samples were obtained to measure inflammatory (CRP, PCT, IL‐6, IL‐17, TNF‐α) and cerebral biomarkers (S‐100β, NSE, HAB42, SUBP). Patients were categorized according to the presence of delirium.ResultsDelirium was present in 10/22 of the patients (45.5%). Serum S‐100β levels were above the laboratory cutoff value of 0.15 μg/L in 13/22 (59.1%) of the patients. The odds ratio for risk of developing delirium in cases with an S‐100β >0.15 μg/L was 18.0 (95%CI, 1.7‐196.3, P = 0.011). Patients with delirium had higher plasma levels of IL‐6 compared to those without; 138.3 pg/mL [28.0‐296.7] vs 53.6 pg/mL [109.3‐505, P = 0.050]. There was a positive correlation between S100 β and IL‐6 levels (r = 0.489, P = 0.021). Delirium patients had higher SOFA scores; 10 [5‐9] vs 7[8‐10.5], P = 0.036.ConclusionsDelirium in septic shock was associated with an elevated protein S‐100β when using a laboratory cutoff value of 0.15 μg/L and with more severe organ dysfunction during the ICU stay.
Risk factors for suicide in bipolar disorder: a cohort study of 12 850 patients
Authors: Hansson C. , Joas E. , Pålsson E. , Hawton K. , Runeson B. , Landén M. 
Published: August 2018

ObjectiveBipolar disorder carries a high risk of suicide. Identification of risk factors is important. The aim of this study was to study risk factors for suicide in a large cohort of men and women with bipolar disorder.MethodA prospective cohort study using clinical data from the Swedish National Quality Register for Bipolar Affective Disorder (BipoläR). The outcome variable was suicide captured in the Cause of Death Register between 2004 and 2014. Hazard ratios (HR) were calculated using Cox proportional hazards models.ResultsOf 12 850 persons (4844 men and 8006 women) with bipolar disorder, 90 (55 men and 35 women) died by suicide during the follow‐up period (between 1 and 10 years). Male sex (HR 2.56), living alone (HR 2.45), previous suicide attempts (HR 4.10), comorbid psychiatric disorder (HR 2.64), recent affective episodes (HR 2.39), criminal conviction (HR 4.43), psychiatric inpatient care (HR 2.79), and involuntary commitment (HR 3.50) were significant risk factors for suicide. Several of the statistically significant risk factors for suicide in bipolar disorder differed between men and women.ConclusionsRisk factors for suicide in bipolar disorder include factors associated with suicide in general, but also diagnosis‐specific factors.
Genome‐wide association study to identify genomic regions affecting prolificacy in Lori‐Bakhtiari sheep
Authors: Abdoli R. , Mirhoseini S. Z. , Ghavi Hossein‐Zadeh N. , Zamani P. , Gondro C. 
Published: August 2018

SummarySeveral causative mutations in candidate genes affecting prolificacy have been detected in various sheep breeds. A genome‐wide association study was performed on estimated breeding values for litter size in Lori‐Bakhtiari sheep. Prolific ewes with twinning records and others with only singleton records were genotyped using the medium‐density Illumina Ovine SNP50 array. Four single nucleotide polymorphisms (SNPs) associated with litter size were identified on chromosomes 3, 6 and 22. The region on sheep chromosome 3 between 75 739 167 and 75 745 152 bp included two significant SNPs (s52383.1 and OAR3_80038014_X.1) in high linkage disequilibrium with each other. The region that surrounds these SNPs contains a novel putative candidate gene: luteinizing hormone/choriogonadotropin receptor (LHCGR), known to be involved in ovarian steroidogenesis and organism‐specific biosystem pathways in sheep. Known prolificacy genes BMPR1B, BMP15 and GDF9 were not associated with litter size in Lori‐Bakhtiari sheep, suggesting that other biological mechanisms could be responsible for the trait's variation in this breed.
Decidual stromal cell‐derived PGE2 regulates macrophage responses to microbial threat
Authors: Rogers Lisa M. , Anders Anjali P. , Doster Ryan S. , Gill Elizabeth A. , Gnecco Juan S. , Holley Jacob M. , Randis Tara M. , Ratner Adam J. , Gaddy Jennifer A. , Osteen Kevin , Aronoff David M. 
Published: August 2018

ProblemBacterial chorioamnionitis causes adverse pregnancy outcomes, yet host‐microbial interactions are not well characterized within gestational membranes. The decidua, the outermost region of the membranes, is a potential point of entry for bacteria ascending from the vagina to cause chorioamnionitis. We sought to determine whether paracrine communication between decidual stromal cells and macrophages shaped immune responses to microbial sensing.Method of studyDecidual cell‐macrophage interactions were modeled in vitro utilizing decidualized, telomerase‐immortalized human endometrial stromal cells (dTHESCs) and phorbol ester‐differentiated THP‐1 macrophage‐like cells. The production of inflammatory mediators in response to LPS was monitored by ELISA for both cell types, while phagocytosis of bacterial pathogens (Escherichia coli and Group B Streptococcus (GBS)) was measured in THP‐1 cells or primary human placental macrophages. Diclofenac, a non‐selective cyclooxygenase inhibitor, and prostaglandin E2 (PGE2) were utilized to interrogate prostaglandins as decidual cell‐derived paracrine immunomodulators. A mouse model of ascending chorioamnionitis caused by GBS was utilized to assess the colocalization of bacteria and macrophages in vivo and assess PGE2 production.ResultsIn response to LPS, dTHESC and THP‐1 coculture demonstrated enhancement of most inflammatory mediators, but a potent suppression of macrophage TNF‐α generation was observed. This appeared to reflect a paracrine‐mediated effect of decidual cell‐derived PGE2. In mice with GBS chorioamnionitis, macrophages accumulated at sites of bacterial invasion with increased PGE2 in amniotic fluid, suggesting such paracrine effects might hold relevance in vivo.ConclusionThese data suggest key roles for decidual stromal cells in modulating tissue responses to microbial threat through release of PGE2.
Preterm premature rupture of membranes: Which criteria contraindicate home care management?
Authors: Petit Céline , Deruelle Philippe , Behal Hélène , Rakza Thameur , Balagny Sara , Subtil Damien , Clouqueur Elodie , Garabedian Charles 
Published: August 2018

AbstractIntroductionHome care management offers a suitable alternative to hospitalization for management of preterm premature rupture of membranes (PPROM). Eligibility criteria have not been clearly established. Our aim was to determine predictive factors of complication during home care management of PPROM in order to define optimal eligibility criteria.Material and methodsRetrospective cohort study of all women with singleton pregnancies with PPROM managed as outpatients between 2009 and 2015. Complications were defined as the occurrence of one of these events: fetal death, placental abruption, umbilical cord prolapse, delivery outside maternity hospital, neonatal death.ResultsIn all, 187 women with PPROMs were managed as outpatients, of whom 12 had a complication (6.4%). In the “complication” group, gestational age at diagnosis (P = 0.006) and at delivery (P < 0.001) were lower, with no difference in latency between these two events. Three criteria significantly increased the risk for a severe complication: PPROM occurring before 26 weeks (P = 0.008), non‐cephalic fetal presentation (P = 0.02) and oligoamnios (P = 0.02). When unfavorable criteria were associated with PPROM, the risk was increased (1 criterion, odds ratio [OR] 1.6; 2 criteria, OR 6.9 and 3 criteria, OR 32.8).ConclusionsCombination of these three criteria is an indication for conventional hospitalization to limit maternal and fetal morbidity. When two criteria are combined, home care should be discussed for each case. If only one unfavorable criteria is present, outpatient management is suitable. To validate these results, a prospective randomized study should be conducted.
Artificial Sphincters to Manage Urinary Incontinence: A Review
Authors: Marziale Leonardo , Lucarini Gioia , Mazzocchi Tommaso , Gruppioni Emanuele , Castellano Simona , Davalli Angelo , Sacchetti Rinaldo , Pistolesi Donatella , Ricotti Leonardo , Menciassi Arianna 
Published: August 2018

AbstractUrinary incontinence affects more than 300 million people worldwide. The implantation of a medical device called an artificial urinary sphincter (AUS) is the gold standard treatment when conservative and minimally invasive therapies fail. In this article, the AUSs (extra‐urethral and endo‐urethral sphincters) available on the market, both presented at the research level and filed as patents, are reviewed. The ability of the different solutions to effectively replace the natural sphincter are discussed, together with advantages and some possible side effects, such as tissue atrophy, overall invasiveness of the implant, and so forth. Finally, future research priorities are discussed for both endo‐urethral and extra‐urethral approaches considering key engineering aspects, such as materials, compression and closure mechanisms, and implantation methods, with the long‐term aim of developing an effective, reliable, durable, and minimally invasive AUS capable of restoring a normal quality of life for incontinent patients.
Case of reduction en masse who presented with no symptoms
Authors: Cao Yuchen , Kohga Atsushi , Kawabe Akihiro , Yajima Kiyoshige , Okumura Takuya , Yamashita Kimihiro , Isogaki Jun , Suzuki Kenji 
Published: August 2018

AbstractThe early and accurate diagnosis of reduction en masse followed by proper treatment is important but has been difficult. Here, we report the case of a 58‐year‐old Japanese man who presented with abdominal pain and vomiting at a nearby clinic. He was referred to our hospital on suspicion of small bowel obstruction. Despite the total disappearance of his symptoms, the abdominal X‐ray examination showed distended loops of small bowel. The preoperative diagnosis of small bowel strangulation due to an internal hernia was made by CT, and we therefore performed emergency exploratory laparoscopy. We intraoperatively diagnosed the patient with the reduction en masse of a right inguinal hernia, and we conducted a transabdominal preperitoneal hernioplasty. This patient's case demonstrates that even when a patient is asymptomatic after the reduction of an inguinal hernia, the possibility of a reduction en masse remains.
Planned cesarean or vaginal delivery for women in spontaneous labor with a twin pregnancy: A secondary analysis of the Twin Birth Study
Authors: Mei‐Dan Elad , Dougan Claire , Melamed Nir , Asztalos Elizabeth V. , Aviram Amir , Willan Andrew R. , Barrett Jon F. R. 
Published: August 2018

AbstractBackgroundThe Twin Birth Study, a multicenter randomized controlled trial, found no differences in neonatal outcomes in women with twins randomized to planned cesarean or vaginal delivery. Nevertheless, women who present in spontaneous labor might expect a better outcome following a trial of vaginal delivery than undergoing cesarean delivery. In this secondary analysis, we aimed to compare neonatal outcomes of women who presented in spontaneous labor in the two arms of the Twin Birth Study.MethodsWomen in whom the first twin was in the cephalic presentation were randomized between 32 + 0 and 38 + 6 weeks to planned vaginal delivery or cesarean. The primary outcome was a composite of fetal or neonatal death or serious neonatal morbidity.ResultsOf the 2804 women included in the Twin Birth Study, 823 women in the planned vaginal delivery arm and 612 in the planned cesarean arm presented in spontaneous labor. Although the odds ratio favored planned vaginal delivery, there was no statistically significant difference in the rate of primary outcome between the vaginal delivery and cesarean arms (1.8% vs 2.7%, respectively; P = 0.16; OR 1.49; 95% CI, 0.87‐2.55). Similarly, the rates of the individual components of the primary outcome and of maternal adverse outcome were similar between the two arms.ConclusionIn women with twins who present in spontaneous labor between 32 + 0 and 38 + 6 weeks’ gestation, where the first twin is cephalic, a policy of planned vaginal delivery or cesarean is not associated with significant differences in neonatal or maternal outcomes.
The MCL35 gene expression proliferation assay predicts high‐risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy
Authors: Holte Harald , Beiske Klaus , Boyle Merrill , Trøen Gunhild , Blaker Yngvild N. , Myklebust June , Kvaløy Sunniva , Rosenwald Andreas , Lingjærde Ole C. , Rimsza Lisa M. , Smeland Erlend B. , Scott David W. , Kolstad Arne 
Published: August 2018

SummaryPatients with mantle cell lymphoma (MCL) generally have a dismal prognosis. Intensified induction treatment with rituximab and high dose cytarabine (R_HDAC), and consolidation with high‐dose therapy with autologous stem cell support has resulted in 10‐year overall survival (OS) higher than 60%. However, the clinical course varies. Diagnostic tools capable of stratifying patients include the MCL International Prognostic Index (MIPI), gene expression‐based proliferation signature, Ki‐67 proliferation index or tumour cell morphology. Here, we tested the performance of a newly developed Nanostring‐based RNA expression‐based proliferation assay (MCL35) on formalin‐fixed paraffin‐embedded tumour tissue from younger patients recruited in or treated according to Nordic MCL protocols compared to the prognosticators listed above. Seventy‐four patients were included and the assay performed well in all cases except four, which had inadequate RNA quality. The patients were evenly distributed in the MCL35 low‐, intermediate‐ and high‐risk categories. MCL35 low‐ and intermediate‐ risk groups had overlapping progression‐free survival (PFS), while patients in the high‐risk category had significantly inferior PFS. Combining MCL35 with MIPI or the MIPI‐C (MIPI with the addition of binary Ki67 score +/−30%) showed a better discrimination than either assessment alone. In conclusion, the MCL35 assay alone or combined with MIPI or MIPI‐C scores can identify patients who still have a dismal outcome despite intensified treatment.
Inherited variation in the xenobiotic transporter pathway and survival of multiple myeloma patients
Authors: Macauda Angelica , Castelli Eleonora , Buda Gabriele , Pelosini Matteo , Butrym Aleksandra , Watek Marzena , Kruszewski Marcin , Vangsted Annette Juul , Rymko Marcin , Jamroziak Krzysztof , Abildgaard Niels , Haastrup Eva Kannik , Mazur Grzegorz , Ríos Rafael , Jurczyszyn Artur , Zawirska Daria , Dudziński Marek , Raźny Małgorzata , Dutka Magdalena , Tomczak Waldemar , Suska Anna , Druzd‐Sitek Agnieszka , Marques Herlander , Petrini Mario , Markiewicz Miroslaw , Martinez‐Lopez Joaquin , Ebbesen Lene Hyldahl , Iskierka‐Jażdżewska Elżbieta , Sainz Juan , Canzian Federico , Campa Daniele 
Published: August 2018

SummaryOver the past four decades, remarkable progress has been made in the treatment and prognosis of multiple myeloma (MM), although it remains an incurable disease. Chemotherapy resistance is a major hurdle for treatment efficacy. Drug resistance can be innate and so driven by genes involved in the drug metabolism pathways. We performed an association study of 71 germline variants within the major genes in those pathways (ABCB1, ABCC2, ABCG2, and their regulators NR1I2/PXR and NR1I3/CAR) in the International Multiple Myeloma rESEarch (IMMEnSE) consortium, consisting of 1365 MM cases with survival information recruited in 5 European countries. Two of the SNPs showed a significant association with the survival of MM patients, namely rs2235013, located in ABCB1 [Hazard ratio (HR) = 1·52, 95% confidence interval (CI) = 1·18–1·95, P = 0·00087], and rs4148388, located in ABCC2 (HR = 2·15, 95% CI = 1·44–3·22, P = 0·0001). ABCC2 plays an essential role in transporting various anticancer drugs, including several used against MM, out of the cell. In silico analyses predict that the variant alleles of four SNPs in linkage disequilibrium with ABCC2‐rs4148388 are associated with increased gene expression. Overexpression of ABCC2 increases drug clearance and therefore may induce drug resistance mechanisms. In conclusion, we found a promising association between ABCC2‐rs4148388 and MM outcome that is supported by a plausible biological explanation.
Gallium‐68‐prostate‐specific membrane antigen (68Ga‐PSMA) positron emission tomography (PET)/computed tomography (CT) predicts complete biochemical response from radical prostatectomy and lymph node dissection in intermediate‐ and high‐risk prostate cancer
Authors: van Leeuwen Pim J. , Donswijk Maarten , Nandurkar Rohan , Stricker Phillip , Ho Bao , Heijmink Stijn , Wit Esther M.K. , Tillier Corinne , van Muilenkom Erik , Nguyen Quoc , van der Poel Henk G. , Emmett Louise 
Published: August 2018

ObjectiveTo determine the value of gallium‐68‐prostate‐specific membrane antigen (68Ga‐PSMA)‐11 positron emission tomography (PET) /computed tomography (CT) in men with newly diagnosed prostate cancer.Patients and methodsWe analysed results of 140 men with intermediate‐ and high‐risk prostate cancer. All men underwent 68Ga‐PSMA‐11 PET/CT and multiparametric magnetic resonance imaging (mpMRI) before radical prostatectomy (RP) with extended pelvic lymph node (LN) dissection. For each patient, the clinical and pathological features were recorded. Prostate‐specific antigen (PSA) was documented at staging scan, and after RP, at a median (interquartile range) of 110 (49–132) days. A PSA level of ≥0.03 ng/mL was classified as biochemical persistence (BCP). Logistic regression was performed for association of clinical variables and BCP.ResultsIn these 140 patients with intermediate‐ and high‐risk prostate cancer, 27.1% had PSMA PET/CT‐positive findings in the pelvic LNs. Sensitivity and specificity for detection of LN metastases were 53% and 88% (PSMA PET/CT) and 14% and 99% (mpMRI), respectively. The overall BCP rate was 25.7%. The BCP rate was 16.7% in men who were PSMA PET/CT LN‐negative compared to 50% in men who were PSMA PET/CT LN‐positive (P < 0.05). The presence of PSMA‐positive pelvic LNs was more predictive of BCP after RP than cT‐stage, PSA level, and the Gleason score, adjusted for surgical margins status.Conclusions68Ga‐PSMA‐11 PET/CT is highly predictive of BCP after RP, and should play an important role informing men with intermediate‐ or high‐risk prostate cancer.