bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the efficacy of a virtual reality-based safety training and human factors training method: study protocol for a randomised-controlled trial
Authors: Nykänen Mikko , Puro Vuokko , Tiikkaja Maria , Kannisto Henriikka , Lantto Eero , Simpura Frans , Uusitalo Jose , Lukander Kristian , Räsänen Tuula , Teperi Anna-Maria 
Published: August 2019

BackgroundThe construction industry has a high risk of occupational accidents and injuries. More randomised controlled trials are needed to identify effective techniques for improving the occupational safety of construction sector workers. New technologies such as virtual reality (VR) offer the potential to develop engaging learning tools for safety training. Although the number of VR applications in occupational safety training is increasing, only a few studies have evaluated the learning outcomes of VR safety training. Furthermore, previous studies indicate that learning to recognise human factors at work has positive outcomes for safety skills. However, there is lack of knowledge regarding the efficacy of human factors-related training in the construction industry.ObjectiveTo evaluate the efficacy and the implementation process of a VR-based safety training and a human factors-related safety training.MethodsIn Finland, 8 study organisations and approximately 130 construction sector workers will participate in a randomised controlled trial. The study participants will be randomly assigned to one of four intervention arms: (1) immersive VR safety training alone, (2) lecture-based safety training alone, (3) combined immersive VR safety training and HF Tool training or (4) combined lecture-based safety training and HF Tool training. We will test the efficacy of the safety training processes in these four arms. Randomisation of study participants is stratified by work experience. Baseline assessment will take place before randomisation. The short-term follow-up measurements of all study participants will be conducted immediately after the VR safety training and lecture-based safety training. The study participants will complete second measurements immediately after the HF Tool training approximately 1 month after previous safety training. The second measurement of the intervention arms 1 and 2 study participants will be conducted during the same week as that of the intervention arms 3 and 4 participants, who will not take part in the HF Tool training. Finally, semistructured individual interviews will be conducted to evaluate the learning process.Outcome measuresOutcome measures include safety knowledge, safety locus of control, safety self-efficacy, perceived control over safety issues, safety-related outcome expectancies, safety motivation and safety performance.DiscussionStudy results will provide knowledge on the efficacy of VR safety training and human factors-related safety training. Furthermore, study provides knowledge on pedagogical techniques that can be used to guide future intervention plans and development.Trial registration numberISRCTN55183871.
Drowning mortality in children aged 0–14 years in Victoria, Australia: detailed epidemiological study 2001–2016
Authors: Chang Susan Soon Mee , Ozanne-Smith Joan 
Published: August 2019

BackgroundMajor reductions in child drowning mortality rates have been observed historically in Victoria, Australia, for the period 1863–2000. Despite this trend, drowning remains the leading cause of unintentional child death in Victoria. This study investigates the residual fatal drowning problem in the Victorian child population (0–14 years) for the period 2001–2016.AimsDescribe the epidemiology of child drowning deaths in the Victorian population in 2001–2016; investigate risk factors and direct antecedents to these deaths.MethodsPopulation-based retrospective case data were extracted from the National Coronial Information System for 16 years (January 2001–December 2016), and case-by-case analysis was conducted. Associated factors were determined using univariate and Poisson analyses.Results88 of 97 cases had information available for analysis, pools were the most frequent location (30%); 70% of all cases occurred between 08:00 and 17:00; most victims were not deliberately in the body of the water (73%), for example, the pool. Supervision lapses included carers leaving the room when the child was in the bath (16/18), siblings left to supervise the child in private pools (7/23), inadequate pool fences (8/23) or faulty/open gates (4/23), or neighbours’ pool spa (4/23). Delays in finding the child occurred when searches occurred elsewhere, before the body of water (21/88) and when carers were asleep (5/88). Fourteen of the 88 children had an intellectual disability or predisposing medical condition. The grouped Poisson analysis demonstrated that age 0–4 years, male gender and rural place of residence were significant. A downward trend in drowning rate continued in this period.Discussion and conclusionsA case-by-case analysis of a drowned population of children identified details of risk factors and antecedents not previously described. Missing data on antecedents were common, likely resulting in undercounting. Further enhancements to systematic data collection are needed. The results support a systems approach to drowning prevention.
Cholangiolar pattern and albumin in situ hybridisation enable a diagnosis of intrahepatic cholangiocarcinoma
Authors: Brackett Diane G , Neyaz Azfar , Arora Kshitij , Masia Ricard , Mattia Anthony , Zukerberg Lawerence , Misdraji Joseph , Goyal Lipika , Zhu Andrew X , Ferrone Cristina R , Yilmaz Omer H , Deshpande Vikram 
Published: August 2019

AimsThe histological distinction of intrahepatic cholangiocarcinoma (ICC) from metastatic adenocarcinoma remains a challenge. The primary goal was to evaluate the diagnostic value of morphology and albumin expression in the diagnosis of ICC.MethodsWe evaluated morphological patterns in 120 ICCs and 677 non-hepatic adenocarcinomas and performed in situ hybridisation (ISH) stain for albumin in the former cohort (retrospective cohort). We also identified 119 samples from primary and metastatic lesions, the validation cohort, in which albumin ISH was performed as part of the diagnostic workup. Targeted sequencing was performed on selected cases. We also mined existing expression profiling data including cases from The Cancer Genome Atlas (TCGA) (41 760 unique samples).ResultsIn the retrospective cohort, 45% of ICCs and <1% of non-hepatic adenocarcinomas showed a cholangiolar pattern; albumin ISH was positive in 93% of ICCs with significant intratumorous heterogeneity. In the validation cohort, 29% of ICCs showed a cholangiolar pattern and 88% expressed albumin, while all metastatic non-hepatic neoplasms were negative (n=37) (sensitivity 88% and specificity 100%). Targetable genetic alterations (IDHmutations andFGFR2fusions) were identified in 31% of ICCs (10 of 32). An analysis of the TCGA data validated the specificity of the albumin assay.ConclusionsThe cholangiolar pattern and albumin RNA ISH distinguishes ICC from metastatic adenocarcinoma with high specificity. Given the high prevalence of targetable mutations in ICC, albumin RNA ISH is an essential component in the workup of tumours of uncertain origin. A specific diagnosis of ICC could trigger molecular testing and uncover targetable genetic alterations.
Subthalamic suppression defines therapeutic threshold of deep brain stimulation in Parkinson’s disease
Authors: Milosevic Luka , Kalia Suneil K , Hodaie Mojgan , Lozano Andres , Popovic Milos R , Hutchison William 
Published: August 2019

IntroductionSubthalamic deep brain stimulation (DBS) is beneficial when delivered at a high frequency. However, the effects of current amplitude and pulse width on subthalamic neuronal activity during high-frequency stimulation have not been investigated.MethodsIn 20 patients with Parkinson’s disease each undergoing subthalamic DBS, we recorded single-unit subthalamic activity using one microelectrode, while a separate microelectrode was used to deliver 5–10 s trains of stimulation at 100 Hz using varying current amplitudes and pulse widths (44 neurons investigated).ResultsAnalysis of variance tests confirmed significant (p<0.001) main effects of both current amplitude and pulse width on subthalamic neuronal firing during stimulation and on poststimulus inhibitory silent periods. Prolonged silent periods were often followed by postinhibitory rebound burst excitations. Additionally, a significant (p<0.0001) correlation was found between neuronal firing and total electrical energy delivered (TEED). With TEED values≤31.2 µJ/s (associated with DBS parameters of ≤2.0 mA, 130 Hz stimulation frequency and 60 µs pulse width, assuming 1 kΩ impedance), neuronal firing was sustained at a rate of 32.4%±3.3% (mean±SE), while with values>31.2 µJ/s, neurons fired at only 4.3%±1.2%.ConclusionsNeuronal suppression is likely an important mechanism of action of therapeutically beneficial subthalamic DBS, which may underlie clinically relevant behavioural changes.
Ethnic variations in sexual partnerships and mixing, and their association with STI diagnosis: findings from a cross-sectional biobehavioural survey of attendees of sexual health clinics across England
Authors: Aicken Catherine RH , Wayal Sonali , Blomquist Paula , Fabiane Stella , Gerressu Makeda , Hughes Gwenda , Mercer Catherine H 
Published: August 2019

ObjectivesEthnic differences in partnership types and sexual mixing patterns may contribute to elevated STI diagnosis rates among England’s Black Caribbean (BC) population. We examined the differences between BC and White British/Irish (WBI) sexual health clinic (SHC) attendees’ reported partnerships and sexual mixing, and whether these differences could explain ethnic inequalities in STI, focusing on attendees reporting only opposite-sex partners (past year).MethodsWe surveyed attendees at 16 SHCs across England (May to September 2016), and linked their survey responses to routinely collected data on diagnoses of bacterial STI or trichomoniasis ±6 weeks of clinic attendance (‘acute STI’). Behaviourally-heterosexual BC and WBI attendees (n=1790) reported details about their ≤3 most recent opposite-sex partners (past 3 months, n=2503). We compared BC and WBI attendees’ reported partnerships and mixing, in gender-stratified analyses, and used multivariable logistic regression to examine whether they independently explained differences in acute STI.ResultsWe observed differences by ethnic group. BC women’s partnerships were more likely than WBI women’s partnerships to involve age-mixing (≥5 years age difference; 31.6% vs 25.5% partnerships, p=0.013); BC men’s partnerships were more often ‘uncommitted regular’ (35.4% vs 20.7%) and less often casual (38.5% vs 53.1%) than WBI men’s partnerships (p<0.001). Acute STI was higher among BC women than WBI women (OR: 2.29, 95% CI 1.24 to 4.21), with no difference among men. This difference was unaffected by partnerships and mixing: BC women compared with WBI women adjusted OR: 2.31 (95% CI 1.30 to 4.09) after adjusting for age and partner numbers; 2.15 (95% CI 1.07 to 4.31) after additionally adjusting for age-mixing, ethnic-mixing and recent partnership type(s).ConclusionWe found that differences in sexual partnerships and mixing do not appear to explain elevated risk of acute STI diagnosis among behaviourally-heterosexual BC women SHC attendees, but this may reflect the measures used. Better characterisation of ‘high transmission networks’ is needed, to improve our understanding of influences beyond the individual level, as part of endeavours to reduce population-level STI transmission.
First-in-Human Study of Mivebresib (ABBV-075), an Oral Pan-Inhibitor of Bromodomain and Extra Terminal Proteins, in Patients with Relapsed/Refractory Solid Tumors
Authors: Piha-Paul Sarina A. , Sachdev Jasgit C. , Barve Minal , LoRusso Patricia , Szmulewitz Russell , Patel Sapna Pradyuman , Lara Primo N. , Chen Xiaotian , Hu Beibei , Freise Kevin J. , Modi Dimple , Sood Anjla , Hutti Jessica E. , Wolff Johannes , O'Neil Bert H. 
Published: August 2019

AbstractPurpose:Bromodomain and extraterminal (BET) proteins play important roles in transcriptional regulation relevant to cancer pathogenesis, and therapeutic targeting/inhibition of BET causes apoptosis of cancer cells in vitro. In this first-in-human study of the pan-BET inhibitor mivebresib (ABBV-075), the safety profile, MTD, and recommended phase II dose (RP2D) were determined in patients with advanced solid tumors.Patients and Methods:A 3 + 3 dose escalation for different mivebresib dosing schedules [daily, Monday/Wednesday/Friday (M-W-F), 4 days on/3 off (4/7)] was followed by dose expansion in patients with prostate cancer. Endpoints were safety, tolerability, pharmacokinetics, and preliminary antitumor activity.Results:Seventy-two patients with solid tumors (14% uveal melanoma; 11% colorectal; 11% breast; 8% pancreatic; 7% head/neck; 49% others) were treated with mivebresib during dose escalation, and 12 additional patients with prostate cancer in expansion cohort. Most common treatment-emergent adverse events (TEAE) related to mivebresib were dysgeusia (49%), thrombocytopenia (48%), fatigue (26%), and nausea (25%). Most common grade 3/4 TEAEs related to mivebresib were thrombocytopenia (35%) and anemia (6%). Dose-limiting toxicities included thrombocytopenia (2 mg daily; 4.5 mg M-W-F), gastrointestinal bleed (2 mg daily), hypertension (2–3 mg 4/7), fatigue, decreased appetite, and aspartate aminotransferase elevation (4 mg M-W-F). Of 61 evaluable patients from dose escalation, 26 (43%) had stable disease and 35 (57%) had progressive disease. Median progression-free survival was 1.8 months (95% confidence interval, 1.8–1.9).Conclusions:On the basis of safety and tolerability, mivebresib RP2D is 1.5 mg for the daily schedule, 2.5 mg for 4/7, and 3 mg for M-W-F. Mivebresib has a tolerable safety profile, and stable disease was observed in some patients with malignant solid tumors.
A Single-Arm, Multicenter, Phase II Study of Camrelizumab in Relapsed or Refractory Classical Hodgkin Lymphoma
Authors: Song Yuqin , Wu Jianqiu , Chen Xinchuan , Lin Tongyu , Cao Junning , Liu Yanyan , Zhao Yaozhong , Jin Jie , Huang Haiwen , Hu Jianda , Luo Jun , Zhang Liling , Xue Hongwei , Zhang Qingyuan , Wang Weiwei , Chen Chunxia , Feng Jifeng , Zhu Jun 
Published: August 2019

Abstract

Purpose:
For classical Hodgkin lymphoma (cHL), programmed death-l (PD-1) is a well-recognized attractive target. This multicenter, single-arm, phase II study evaluated the efficacy and safety of camrelizumab, a humanized high-affinity IgG4 mAb against PD-1, in Chinese patients with relapsed or refractory cHL.

Patients and Methods:
Patients who had failed to achieve a remission or experienced progression after autologous stem cell transplantation or had received at least two lines of systemic chemotherapies were given camrelizumab 200 mg every 2 weeks. The primary endpoint was objective response rate per independent review committee (IRC) assessment. This study is registered with ClinicalTrials.gov (NCT03155425).

Results:
Between June 9, 2017 and September 18, 2017, 75 patients were enrolled and treated. At a median follow-up of 12.9 months, 57 of 75 (76.0%; 95% CI, 64.7–85.1) patients achieved an IRC-assessed objective response, including 21 (28.0%) and 36 (48.0%) patients who had complete and partial remission, respectively. Median duration of response was not reached (range, 0.0+–12.8+ months). Treatment-related adverse events (AE) occurred in all patients. The most common ones included cutaneous reactive capillary endothelial proliferation (97.3%, 73/75) and pyrexia (42.7%, 32/75). Grade 3 or 4 treatment-related AEs occurred in 20 patients (26.7%); the most common AE was decreased white blood cell count (4.0%, 3/75). There were no grade 5 treatment-related AEs.

Conclusions:
Camrelizumab demonstrated a high response rate, durable response and controllable safety in Chinese patients with relapsed or refractory cHL, becoming a new safe and effective treatment option in this setting.
Mollusk bycatch in trawl fisheries targeting the Atlantic seabob shrimp Xiphopenaeus kroyeri on the coast of Sergipe, northeastern Brazil
Authors: Mendonça Luana Marina De Castro , Guimarães Carmen Regina Parisotto , Lima Silvio Felipe Barbosa 
Published: August 2019

The malacofauna bycatch of sea-bob shrimp Xiphopenaeus kroyeri (Heller, 1862) trawl fisheries on the coast of Sergipe was studied for 5 years. The malacofauna bycatch considered was obtained in nine oceanographic sampling campaigns carried out between May 1999 and June 2003 in 18 stations distributed in six transects along depths of 10, 20 and 30 m. A total of 2,669 individuals of mollusk belonging to 54 species were captured on the 18 sea-bob shrimp trawl stations carried out along the coast of Sergipe. The considerable richness of mollusks was composed by 19 families and 31 species of gastropods, 12 families and 19 species of bivalves and 2 families and 4 species of cephalopods. The highest abundance were observed at stations 13 (373 individuals) and 16 (685 individuals) that represents the lowest depth (10 m) and the richness was higher at stations 15 and 12 (17 and 11 species, respectively) both located at the highest depth (30 m). Cephalopods had high frequency of occurrence being collected in all the stations and by far the most abundant group with a total of 2,488 individuals captured. On the other hand, gastropods (with 142 individuals found in 83.3% of stations) and bivalves (about 1% of the individuals collected) contribute with a much smaller percentage of individuals captured. Lolliguncula brevis (Blainville, 1823) was most representative cephalopod in number and frequency of occurrence. Arcidae, Conidae, Muricidae and Strombidae were the families with the higher number of species in the trawl-fishery. Among bivalves, Pitar arestus (Dall & Simpson, 1901) and Spathochlamys benedicti (Verrill & Bush [in Verrill], 1897) were the species with higher frequency of occurrence. Although the considerable sample effort and a number of mollusks captured as bycath, the richness estimators indicated that the species richness could increase with additional sampling effort in the study area. The present study expands the taxonomic alpha knowledge on the mollusk bycatch of sea-bob shrimp trawl fisheries on the northeastern coast of Brazil. However, it is of crucial importance to assess urgently the negative impacts of the sea-bob shrimp trawl fisheries on the benthic community of the entire coast of Brazil.
Birds of Parque Estadual do Tainhas, an important protected area of the highland grasslands of Rio Grande do Sul, Brazil
Authors: Chiarani Eduardo , Fontana Carla Suertegaray 
Published: August 2019

Parque Estadual do Tainhas – PET (Tainhas State Park) is a protected area with significant extensions of natural grasslands located in highland grasslands of northeastern Rio Grande do Sul state, Brazil, and recognized as an Important Bird Area. Our aim was to record the bird species richness of PET with a greater sampling effort than previous studies at the site, including unpublished data such as occurrence status of most species and evidence of breeding of some of them in the park. We surveyed birds between 2012 and 2018 performing aleatory trails covering mainly the central portion of PET (1,500 ha). We also added records from published studies. We listed 208 species, of which 203 were recorded during our fieldwork (including 18 species of conservation concern). The estimated richness was 222.22 (SD = 10.91) species, according to Jackknife 1 method. This result represents a 58% increase in the species richness of the park and shows that long-term monitoring of the bird community allows to access more accurate richness and to identify the regular species (core avifauna) of the park. The presence of 55 breeders and threatened species shows the importance of this protected area for breeding and conservation of grassland birds, such as Urubitinga coronata, Cinclodes pabsti, Xolmis dominicanus, Anthus nattereri, Xanthopsar flavus, and Sporophila melanogaster.
A new species of Oiovelia from Colombia, with notes for other three species of South American Veliinae (Heteroptera: Gerromorpha: Veliidae)
Authors: Rodrigues Higor D.D. , Álvarez Arango Luisa Fernanda 
Published: August 2019

The new species Oiovelia shepardi is described based on macropterous specimens from the departments of La Guajira and Antioquia in northwestern Colombia, and is compared to its presumed closest relative. The female of Paravelia cunhai Rodrigues & Moreira, 2016 and the male of P. polhemusi Rodrigues, Moreira, Nieser, Chen & Melo, 2014 are described for the first time. The specimens of the two species of Paravelia Breddin were collected in waters inside caves in the State of Pará, northern Brazil. Further, the micropterous form of Steinovelia vinnula (Drake, 1951) is described, compared with S. virgata (White, 1879), and new distributional records are provided. Illustrations and a geographic distribution map of all species treated here are presented.
An overview of the ant fauna (Hymenoptera: Formicidae) of the state of Maranhão, Brazil
Authors: Prado Lívia Pires do , Feitosa Rodrigo Machado , Triana Stefania Pinzón , Gutiérrez Jhonatan Andrés Muñoz , Rousseau Guillaume Xavier , Silva Raimunda Alves , Siqueira Glécio Machado , Santos Ciro Líbio Caldas do , Silva Francisco Veras , Silva Thiago Sanches Ranzani da , Casadei-Ferreira Alexandre , Silva Rogério Rosa da , Andrade-Silva Joudellys 
Published: August 2019

The state of Maranhão, located in northeastern Brazil, comprises three biomes: Amazonian, Caatinga, and the Cerrado. To date, 99 ant species have been recorded in the literature from the state. In the present work, we provide for the first time a profile of the ant fauna in the state based on data from the historical literature and Brazilian institutional collections. The updated records on ant diversity for the state of Maranhão revealed a total of 279 species, belonging to 71 genera and 10 subfamilies. In total, 180 species are recorded for the first time in the state, of which four species recorded for the first time in Brazil. In summary, apart from documenting the ant fauna of the region, these results provide a basis for further studies and may contribute to future conservation efforts for the biomes present in this complex landscape.
First record of the genus Eumunida Smith, 1883 (Crustacea, Decapoda, Eumunididae) from the southwestern Atlantic, with the description of a new species
Authors: Tavares Marcos , Lima Daniel 
Published: August 2019

Eumunida picta Smith, 1883, was considered for over a century an amphi-Atlantic species and the only representative of the genus in the Atlantic Ocean, until being split into three species: E. picta sensu stricto (from the northwestern Atlantic), E. bella de Saint Laurent & MacPherson, 1990 and E. squamifera de Saint Laurent & MacPherson, 1990 (from the northeastern and southeastern Atlantic, respectively). Eumunida is now expanded to include a new species, E. notialis, from off the Brazilian coast. Hence, this is the first record of Eumunida and Eumunididae from the southwestern Atlantic. The new species differs from all its Atlantic counterparts in having (1) four hepatic spines; (2) two carapace inframarginal spines; (3) the distal end of the antennal acicle nearly reaching to the articulation between fourth and fifth antennal segments; and (4) the anterolateral spine of the second pleonal tergite obsolete.