bluuebunny/crossref_metadata_2025_split huggingface dataset:
A FUNÇÃO SIMBÓLICA DO DIREITO AMBIENTAL: CONSIDERAÇÕES SOBRE O TEMA 30 ANOS DEPOIS DA CONSTITUIÇÃO DE 1988
Authors: Freitas Ana Carla Pinheiro , Pompeu Gina Vidal 
Published: May 2019

A função simbólica do Direito Ambiental é assunto atual e grave. Por esse motivo insiste-se em uma revisita ao tema, 30 anos depois da Constituição de 1988. O presente texto abre discussão acerca das várias definições do conceito de simbólico, no contexto da obra “a constitucionalizacão simbólica”, de Marcelo Neves. O capítulo seguinte é dedicado à apresentação e leitura atualizada do caso concreto citado pelo Prof. Wolf Paul no seu texto, que deu origem à presente discussão acerca da função simbólica do Direito Ambiental. O terceiro capítulo é dedicado ao questionamento sobre a argumentação jurídica como ideologização da verdade que expõe uma verdadeira "aliança entre opostos”. No derradeiro capítulo é abordada a função do Direito, a positivação de novos valores e seus reflexos, na seara do Direito Ambiental. Estes valores encontram-se inseridos no âmbito técnico-racional e no técnico-instrumental. A metodologia seguida baseia-se em pesquisa bibliográfica e em estudo analítico-descritivo e exploratório.
Analysis The Level Of PM2,5 And Lung Function Of Organic Fertilizer Industry Workers In Nganjuk
Authors: Azizah Imfatul Tria Nur 
Published: May 2019

Organic fertilizer industry in Nganjuk uses manure as basic materials of production. Its process produced particulate matter 2,5 (PM2,5) in the form of dust and smoke. PM2,5 can be inhaled and be retained until alveoli, so it is potentially caused lung function impairment to the workers. The objective of this research was to analyzed the level of PM2,5 and lung function of organic fertilizer industry workers in Nganjuk. The type of this research was observasional descriptive quantitative with cross sectional design. The research sample was using total population of 10 production workers. The result of this research showed that the level of PM2,5 inhaled which exceeded Threshold Limit Value (TLV) or > 3 mg/m3 were on 2 workers who worked on drying and packing process. The average of PM2,5 environment level which exceeded TLV were on manufacturing of granuls, heating and packing process area. Workers who had lung function impairment were 4 workers (40%). Lung function impairment more likely found in workers with exposure of PM2,5 inhaled≤ 3 mg/m3, has age 41 – 60 years, worked period < 5 years, always using cloth as respiratory protective equipment, and had worked in the other places either direct or indirect exposure of dust. The conclusion of this research is production workers of organic fertilizer industry in Nganjuk has risk of lung function impairment. Suggestions for the owner of organic fertilizer industry in Nganjuk are to install natural and unnatural ventilations and to provide air purifying respirators.
APPLICATION OF SOMATIC AUDITORY VISUALIZATION INTELLECTUALLY LEARNING STYLE TO IMPROVE THE UNDERSTANDING OF THE CONCEPT OF STRUGGLE TO MAINTAIN INDEPENDENCE
Authors: Pramuharti Marlita , Hartono Hartono , Kuswadi Kuswadi 
Published: May 2019

<table border="0" cellspacing="0" cellpadding="0"><tbody><tr><td valign="top" width="387"><p><em>The purpose of this research is to improve </em><em>the </em><em>understanding of the concept of struggle to maintain independence with the implementation of Somatic Auditory Visualization Intellectually (SAVI) learning model in grade V SD Negeri Setono No.95 Surakarta academic year 2017/2018.</em><em> </em><em>This </em><em>research</em><em> is a classroom action research </em><em> and</em><em> conducted in three cycles and each cycle of two meetings. Each cycle consists of four stages of planning, implementation, observation, and reflection</em><em>. </em><em>Data collection techniques us</em><em>ing</em><em> observation, interviews, documentation, and tests</em><em>.</em><em> </em><em>T</em><em>echnique of data validity test using technique triangulation and content validity. Data analysis technique us</em><em>ing</em><em> interactive analysis model and </em><em>comparative </em><em>descriptive</em><em>. </em><em>The average grade of the class before the action was 43.3 with a percentage of mastery of 2.7% or 1 of 36 students </em><em>that </em><em>reaching the </em><em>minimal mastery criteria</em><em> </em><em>that is </em><em>72.</em><em> </em><em>Finally in cycle III the grade point average increased to 83.87 or 31 of 36 students reached the </em><em>minimal mastery criteria</em><em>.</em><em> </em><em>Thus it can be concluded that the application of Somatic Auditory Visualization Intellectually (SAVI) learning model can improve understanding of the concept of struggle to maintain independence</em><em>.</em><em></em></p><p><em> </em></p></td></tr></tbody></table>
THE IMPLEMENTATION OF COOPERATIVE LEARNING TYPE THINK PAIR SHARE MODEL TO IMPROVE READING COMPREHENSION SKILL IN DISRUPTION ERA
Authors: Latief Maullana , Sriyanto Muhammad Ismail , Daryanto Joko 
Published: May 2019

<p><em>The purpose of this research was to improve the skill of reading comprehension by applied Think Pair Share (TPS) model in disruption era for fifth grade students in SDN Purwotomo No. 97 Surakarta on academic year of 2017/2018.</em><em> </em><em>The form of this research was a Classroom Action Research which conducted in two cycles. Each cycle consisted of four stages i.e. planning, action, observation, and reflection. The subjects of this research included teacher and 23 fifth grade students in SDN Purwotomo No. 97 Surakarta. The data collected by observation, interview, test, and documentation techniques. The data validity test were using content validity, triangulation of resource, and triangulation of technique. </em><em>The result of this research shows the improvement of skill of reading comprehension values from pre-action, cycle I until cycle II</em><em>.</em></p>
The THE EFFECT OF HYDROPONIC GARDENING ACTIVITIES AND PARENT INVOLVEMENT ON CHILDRENâ€™S NATURALISTIC INTELLIGENCE
Authors: Pratiwindya Dini 
Published: May 2019

Living in a big city such as Jakarta that is densely populated and crowded is challenging. The limited open land is an obstacle for schools in urban areas, especially in the Central Jakarta region, to stimulate children's naturalistic intelligence and sometimes become a forgotten thing. The rapid progress of technology and information makes children become electronic addiction and nature deficit disorder. The teacher feels it is difficult to carry out activities related to nature.
The results of preliminary observations show that the naturalistic intelligence of early childhood still has not received attention to be developed. The lack of teacher creativity to create and design activities to improve children's naturalistic intelligence is also another obstacle. Likewise, parent involvement in children's learning activities is still not optimal.
The aims of this study was to look at the effect of hydroponic gardening activities and parents involvement on the naturalistic intelligence of early childhood. This study included an ex post facto study using a quantitative survey research approach to TK B children.
The results of the studyshowed that there were hydroponic gardening activities and parental involvement had a significant influence on naturalistic intelligence in early childhood. Urban farming activities such as hydroponic gardening need to beintroduced to kindergaten teachers to get around the limited land in schools. Hydroponic gardening activities can bedesigned so parents can be involved in learning with children and teachers with a pleasant atmosphere
PERBANDINGAN FORGIVENESS PADA WANITA KORBAN KDRT DITINJAU DARI KEHADIRAN ANAK
Authors: Ariyani Mira , Qonita Maryam 
Published: May 2019

The purpose of this study was to find out the comparison in forgiveness of women victims of domestic violence in terms of the presence of children. The research used quantitative method wtith t-test technique to compare the means of two groups sample. The sample in this study for women with children is 30 respondents. And The sample in this study for women without children is 30 respondents. The sampling techniques used in this research is non probablity sampling test. Data obtained using The Transgression-Related Interpersonal Motivations Inventory-18 (TRIM-18) designed by McCoullough and adopted by researcher. Based on analysis data using independent t-test technique, its known that t t = -,0444 < 2.002; p =0,639 > 0,05. Based on the results, this means that there is no significant difference of forgiveness in women victims of domestic violence reviewed from children presence.
Identification of key genes and regulators associated with carotenoid metabolism in apricot (Prunus armeniaca) fruit using weighted gene co-expression network analysis
Authors: Zhang Lina , Zhang Qiuyun , Li Wenhui , Zhang Shikui , Xi Wanpeng 
Published: May 2019

Abstract
Background: Carotenoids are the main class of terpenoid pigments that contribute to the color and nutritional value of many fruits. However, while their biosynthetic pathway have been well established in a number of model plant species, many details of the regulatory mechanism controlling carotenoid metabolism remain to be elucidated. Apricot (Prunus armeniaca) fruit are rich in carotenoids and substantial amounts accumulate during ripening, making them a valuable system to investigate carotenoid metabolism.
Results: In this study, we compared the apricot transcriptome profiles of bulked samples of ripening fruit. A total of 44,754 unigenes and 6,916 differentially expressed genes were detected during ripening, and 33,498 unigenes were annotated using public protein databases. Weighted gene co-expression network analysis (WGCNA) showed that two of thirteen gene expression modules were highly correlated with carotenoid metabolism, and a total of 33 structural genes involved in the carotenoid biosynthetic pathway were identified. Further, network analysis revealed that the transcription factors ERF4/5, PIF3/4, HY5, MADS14, NAC25, GLK1/2, MYC2 and MYB21/44 have potential regulatory roles in carotenoid metabolism during ripening.
Conclusions: Based on these results, a regulatory network model is proposed. Our findings provide a platform for future functional genomic analysis and provide new insights into carotenoid metabolism.
Full-length transcriptome sequences of Agropyron cristatum facilitate the prediction of putative genes for thousand-grain weight in a wheat-A. cristatum translocation line
Authors: Zhou Shenghui , Zhang Jinpeng , Han Haiming , Zhang Jing , Huihui Ma , Zhang Zhi , Lu Yuqing , Liu Weihua , Yang Xinming , Li Xiuquan , Li Lihui 
Published: May 2019

Abstract
Background

Agropyron cristatum (L.) Gaertn. (2n = 4x = 28; genomes PPPP) is a wild relative of common wheat (Triticum aestivum L.) and provides many desirable genetic resources of wheat improvement. However, there is still a lack of reference genome and transcriptome information for A. cristatum, which severely impedes functional and molecular breeding studies.

Results

Single-molecule long-read sequencing technology from Pacific Biosciences (PacBio) was used to sequence full-length cDNA from a mixture of leaves, roots, stems and caryopses and constructed the first full-length transcriptome dataset of A. cristatum, which comprised 44,372 transcripts. As expected, the PacBio transcripts were generally longer than the transcripts assembled via the Illumina sequencing platform in a previous study. By mapping the full-length transcripts in this study, we identified tissue-enriched expressed transcripts and enriched GO terms, indicating that tissue-enriched transcripts were enriched for particular molecular functions that varies with tissue. We identified 3,398 novel and 1,352 A. cristatum-specific transcripts compared with the wheat gene model set. In order to better apply this transcriptome of A. cristatum, the A. cristatum transcripts was integrated with wheat genome as a reference sequences to try to identify candidate A. cristatum transcripts associated with thousand-grain weight in a wheat-A. cristatum translocation line Pubing 3035.

Conclusions

Full-length transcriptome sequences were used in our study. The present study not only provides comprehensive transcriptomic insights and information for A. cristatum but also proposes a new method for exploring the functional genes of wheat relatives under a wheat genetic background. The sequence data have been deposited in the NCBI under BioProject accession number PRJNA534411.
iTRAQ-based Comparative Proteomic Analysis of Flag Leaves of Two Wheat (Triticum aestivum L.) Genotypes Differing in Waterlogging Tolerance at Anthesis
Authors: Wei Mingmei , Li LiuLong , Xie Ke , Yang Rui , Wang Xiaoyan , Sha Aihua 
Published: May 2019

Abstract
Background

Waterlogging is one of the major abiotic stresses limiting wheat product. Plants can adapt to waterlogging with changes in morphology, anatomy, and metabolism. A number of genes or proteins were responsive to waterlogging.

Results

in this sduty, the iTRAQ-based proteomic strategy was applied to identify waterlogging-responsive proteins in wheat. A total of 7710 proteins were identified in waterlogging tolerant and sensitive wheat varieties XM55 and YM158 at anthesis under waterlogging or not. Sixteen proteins were differentially accumulated between XM55 and YM158 under waterlogging with cultivar specificity. Among them, eleven proteins were up-regulated and five proteins were down-regulated. The up-regulated proteins included Fe-S cluster assembly factor, heat shock cognate 70, GTP-binding protein SAR1A-like, and CBS domain-containing protein. The down-regulated proteins contained photosystem II reaction center protein H, carotenoid 9,10 (9',10')-cleavage dioxygenase-like, psbP-like protein 1, and mitochondrial ATPase inhibitor. In addition, nine proteins were responsive to waterlogging with non-cultivar specificity. These proteins included 3-isopropylmalate dehydratase large subunit, solanesyl-diphosphate synthase 2, DEAD-box ATP-dependent RNA helicase 3, and three predicted or uncharacterized proteins. Sixteen out of the twenty-eight selected proteins showed consistent expression patterns between mRNA and protein levels by quantitative real-time PCR.

Conclusions: Our study indicates the much proteins were differential accumulated between the two contrast waterlogging wheat varieties in response to waterlogging, which provide insight into wheat response to waterlogging stress. The identified differentially accumulated protein might be applied to develop waterlogging tolerant wheat.
Transcriptome analysis of molecular mechanism to pyrethroids resistance in Spodoptera litura
Authors: Li Dongzhi , Mei Yu , Wang Jianhua , Chen Xiling , Wang Chengju , Xu Li 
Published: May 2019

Abstract
Background

Spodoptera litura is a destructive agricultural pest and had evolved resistance to multiple insecticides, especially pyrethroids. At present, the resistance mechanism to pyrethroids remains unclear.

Results

Four field-collected populations, namely CZ, LF, NJ and JD, were identified to have high resistance to pyrethroids, and the resistant ratio ranged from 40.8 to 1764.0-fold. To explore pyrethroids resistance mechanism, the transcriptome between pyrethroid-resistant (LF and NJ) and pyrethroid-susceptible (GX) populations were compared by RNA-sequence. Results showed that multiple differential expressed genes were enriched in metabolism-related GO terms and KEGG pathways. 35 up-regulated metabolism-related genes were screened to verify by qRT-PCR. Consistent up-regulation of 13 unigenes, including 3 P450s, 4 GSTs, 1 UGTs, 4 COEs and 1ABC, were verified in the additional pyrethroids resistant populations CZ and JD. The expression level of CYP3 and GST3, which were homologous to CYP321A8 and GST1, respectively, showed good correlation with their pyrethroids resistance level among CZ, LF, NJ and JD populations. While the expression level of CYP12, CYP14, COE4 and ABC5 showed good correlation with their pyrethroids resistance level in at least three populations. UGT5 had the highest expression level among the tested UGT genes in the four pyrethroids resistant populations.

Conclusion

CYP3, CYP12, CYP14, GST3, COE4, UGT5 and ABC5 play important roles in pyrethroids resistance among the four field-collected populations. Our study provided a valuable resource for further study of pyrethroid resistance mechanisms in S. litura.
Comprehensive analysis of the differentially expressed receptor-like kinase genes in responding to pollination in A. thaliana and B. napus
Authors: Gao Qiguo , Jiang Yupeng , Chen Xingyu , Dong Yuming , Kuang Chen , Wang Xiaoli 
Published: May 2019

Abstract
Background

Successful sexual reproduction in flowering plant requires extensive communications between male and female organs and tissues. Although RLKs have been proved to play critical roles in these communications, so far the identified RLKs are still limited. Here we performed a comprehensive analysis on differentially expressed RLKs in responding to pollination in Arabidopsis thaliana and Brassica napus to contibute to further analysis on RLKs’ function in male-female communication.

Result

In this study, a total of 2,583 B. napus AtRLK orthologs were obtained. 89 AtRLKs showed obvious expression level changes after pollination in A. thaliana or in B. napus. Although 30 differentially expressed AtRLKs were opened anthers and anthers of mature flower before opening preferentially expressed or hydrated pollen-enriched, up to 79 AtRLKs corresponding to 129 B. napus orthologs showed obvious expression level changes at different time points after pollination. Among 89 differentially expressed AtRLKs after pollination, only 7 AtRLKs were shared by differently expressed genes during in vitro pollen tube growth, 3 of 7 AtRLKs’ expression level change tendency after pollination and during PTG were different.

Conclusions

Amount to 89 AtRLKs were differentially expressed in responding to pollination in A. thaliana and B. napus, and their expression level changes should be mainly induced by pollen-stigma interaction, several of them had been proved to function in male-female communication in the former reports.
On the application of the depth-averaged random walk method to solute transport simulations
Authors: Yang Fan , Liang Dongfang , Wu Xuefei , Xiao Yang 
Published: May 2019

Abstract
Most numerical studies on solute mixing rely on mesh-based methods, and complicated schemes have been developed to enhance numerical stability and reduce artificial diffusion. This paper systematically studies the depth-averaged random walk scheme, which is a meshfree method with the merits of being highly robust and free of numerical diffusion. First, the model is used to solve instantaneous release problems in uniform flows. Extensive parametric studies are carried out to investigate the influences of the number of particles and the size of time steps. The predictions are shown to be independent of time steps but are sensitive to the particle numbers. Second, the model is applied to the solute transport problem along an estuary subject to extensive wetting and drying during tidal oscillations. Finally, the model is used to investigate the wind-induced chaotic mixing in a shallow basin. The effect of diffusion on the chaotic mixing is investigated. This study proposes a generic sampling method to interpret the output of the random walk method and highlights the importance of accurately taking diffusion into account in analysing the transport phenomena. The sampling technique also offers a guideline for estimating the total number of particles needed in the application.
Coumarin: A Promising Scaffold for Design and Development of Bioactive Agents
Authors: Alshibl Hanan M. , Al-Abdullah Ebtehal S. , Alkahtani Hamad M. 
Published: May 2019

Background:
As coumarin derivatives are known to prevent and treat various diseases, they
have attracted the attention of medicinal chemists. They have strong potential as drugs because their
benzopyrone structure can interact noncovalently with numerous enzymes and receptors.

Methods:
The aim of this review was to summarize the most recently published literature on coumarin
derivatives in terms of their antioxidant, antimicrobial, anti-inflammatory, anticancer, and other miscellaneous
properties.

Results:
Coumarin derivatives have a wide range of biological activities. They exhibit antioxidant, antimicrobial,
anti-inflammatory, anticancer, anti-coagulant, and anti-Alzheimer effects.

Conclusion:
The coumarin nucleus is an interesting starting point for the design and development of
novel bioactive agents. The present review may help medicinal chemists design biologically active molecules
based on the coumarin nucleus.
Radioprotective Effect of Gliclazide as an Anti-Hyperglycemic Agent Against Genotoxicity Induced by Ionizing Radiation on Human Lymphocytes
Authors: Pouri Maysa , Shaghaghi Zahra , Ghasemi Arash , Hosseinimehr Seyed Jalal 
Published: May 2019

Objectives:
Gliclazide (GL) is widely used to reduce hyperglycemia in diabetic patients.
The aim of this study was to investigate the protective effect of GL against chromosome damage induced
by ionizing radiation in human blood lymphocytes.

Methods:
In this experimental study, peripheral blood samples were collected from human volunteers
and treated with GL at various concentrations (5, 25, 50 or 100 μM) for three hours. Then samples
were irradiated to X-ray (1.5 Gy). Blood samples were cultured with mitogenic stimulation. The
frequencies of micronuclei in cytokinesis-blocked binucleated lymphocytes were determined in the
different samples. The antioxidant activities of GL were assayed by two different methods as 1,1-
diphenyl-2-picryl hydrazyl radical (DPPH) free radical scavenging and reducing antioxidant power
assays.

Results:
GL significantly reduced the percentage of micronuclei in lymphocytes which were irradiated.
The maximum radioprotection in the reduction of percentage of micronuclei in lymphocytes was
observed at 100 μM of GL with 52% efficacy. GL exhibited excellent free radical scavenging activity
and reducing power at concentration dependent activities. The IC50 values of GL were lower than
ascorbic acid. Higher potencies were observed in the antioxidant activities for GL than ascorbic acid
in both methods.

Conclusion:
This data exhibits that GL is a powerful radioprotective agent that could protect healthy
cells against the chromosome damage induced by ionizing radiation through antioxidant activity. The
radioprotective effect is new indication of GL for patients' protection against side effect induced by
ionizing radiation.