bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘It would be much easier if we were just quiet and disappeared’: Parents silenced in the experience of caring for children with rare diseases
Authors: Currie Genevieve , Szabo Joanna 
Published: August 2019

AbstractBackgroundParent experiences of caring for children with neurodevelopmental disease have been silenced and constrained by social, political and health influences. There is a need to co‐construct new meanings and interpretations of parenting a child with complex disabilities by having an increased understanding of the struggles and barriers for parents.MethodsA hermeneutic phenomenology approach was applied in this inquiry. Fifteen parents of children with rare neurodevelopmental diseases participated in semi‐structured interviews.ResultsParents experienced silencing or being silenced within interactions with health‐care and social care systems and providers. Interpretive thematic analysis revealed three insights: (a) parents experience a sense of disconnect and silencing as little is known or understood by health‐care providers about the experience of caring for children at home; (b) parents make strong efforts to be heard and acquire services within health and social systems as fighters, saviours and navigators; and (c) parents sacrifice themselves to the caregiving role and become therapists and caregivers to their medically fragile children at the cost of losing themselves as parents.ConclusionAn understanding of parents’ experiences in caring for a child with a rare neurodevelopmental disease may provide insight to systemic health and social support challenges faced by families and mitigate appropriate and supportive policies and services.
2D/2D SnS2/MoS2 layered heterojunction for enhanced supercapacitor performance
Authors: Wang Bo , Hu Rong , Zhang Jun , Huang Zongyu , Qiao Hui , Gong Lunjun , Qi Xiang 
Published: August 2019

AbstractTwo‐dimensional (2D) SnS2/MoS2 heterojunction with a 2D/2D novel structure was used as electrode material for enhanced supercapacitor performance. Compared with the sole SnS2, the as‐prepared 2D/2D SnS2/MoS2 layered heterojunction has exhibited great improvement in supercapacitor properties. This novel structure can effectively prevent agglomeration and stacking in electrochemical process, and 2D/2D structure is beneficial to intercalation and desorption of ions in electrochemical processes. The experiment result shows that MoSn5 (samples with 5% MoSn5 mole ratios) display a specific capacitance of 466.6 F/g at the current density of 1 A/g in 0.5 mol/L potassium hydroxide solution, an impressive cycling stability with 88.2% capacitance retention at current density of 4 A/g. In addition, the as‐fabricated symmetric supercapacitor exhibited high energy density of 115 Wh kg−1 at the power density of 2230 Wh kg−1. This work provides a fundamental investigation of 2D/2D layered material synergistic effect on the electrochemical process.
Measurement of central augmentation index by three different methods and techniques: Agreement among Arteriograph, Complior, and Mobil‐O‐Graph devices
Authors: Papaioannou Theodore G. , Thymis John , Benas Dimitrios , Triantafyllidi Helen , Kostelli Gavriela , Pavlidis George , Kousathana Fotini , Katogiannis Kostantinos , Vlastos Dimitrios , Lambadiari Vaia , Papadavid Evangelia , Parissis John , Tousoulis Dimitrios , Ikonomidis Ignatios 
Published: August 2019

AbstractWave reflection at central arteries consists of a major component of left ventricular afterload. Central augmentation index (AIx) is the most widely used surrogate of wave reflection. Recent technological developments now provide the ability to obtain, non‐invasively, aortic, or carotid pressure waves and measure AIx based on various algorithms of pulse wave analysis. The aim of this study was to compare AIx measurements performed by the Arteriograph, Complior, and Mobil‐O‐Graph apparatuses. Recordings by each device in randomized order were performed with 5‐minute interval at 211 individuals (age 55.1 ± 14.1 years, 67.8% males) who underwent diagnostic cardiovascular assessment. All measurements were obtained at the supine position, and AIx was calculated using the formula AIx = 100 × (Augmentation pressure)/(Pulse Pressure). Bland‐Altman analysis was performed. Mean difference (bias) ± one standard deviation of difference (with limits of agreement) of AIx between different devices was as follows: (a) Mobil‐O‐Graph vs Complior: −2.1 ± 14.8% (−31.1% to 26.9%), (b) Arteriograph vs Complior: 12.9 ± 14.6% (−15.7% to 41.5%), and (c) Mobil‐O‐Graph vs Arteriograph: −10.8 ± 16.9% (−43.9% to 22.3%). The three examined devices exerted significant differences in central AIx estimation which makes the three devices non‐interchangeable for wave reflection assessment. However, the Mobil‐O‐Graph device showed the highest agreement (lowest bias) with the Complior system as regards to the AIx measurement.
Inaccuracy of buccal bone thickness estimation on cone‐beam CT due to implant blooming: An ex‐vivo study
Authors: Vanderstuyft Tony , Tarce Mihai , Sanaan Bahoz , Jacobs Reinhilde , de Faria Vasconcelos Karla , Quirynen Marc 
Published: August 2019

AbstractAimThe aim of this article was to evaluate the accuracy of buccal bone thickness measurements around implants on CBCT.Material and methodsForty‐four Osseospeed EV implants (3.6 in Ø) were placed guided and flapless in five fresh frozen human cadaver heads. The buccal peri‐implant bone was measured clinically via guided bone sounding. Post‐op CBCTs were taken with two different CBCT scanners (NewTom® and Accuitomo®) on which the buccal bone was measured. Consequently, after implant removal, a new CBCT was made without implant artefacts (image reference standard) on which the real buccal bone thickness was scored.ResultsDue to an average blooming (artificial increase of implant diameter) percentage of 12%–15%, the buccal peri‐implant bone thickness was underestimated by 0.3 mm on both CBCT devices. Immediately adjacent to the implant blooming area, a doubtful zone of about 0.45 mm was observed in which the buccal bone was not always visible. Buccal bone that was thick enough to fall outside this doubtful zone could always be visualized.ConclusionThe findings in this study may help the clinician in the decision‐making process whether or not to intervene surgically in areas with ambiguous CBCT results.
Psychometric properties of the Brief Illness Perception Questionnaire (Brief‐IPQ) in periodontal diseases
Authors: Machado Vanessa , Botelho João , Ramos Catarina , Proença Luís , Alves Ricardo , Cavacas Maria Alzira , Mendes José João 
Published: August 2019

AbstractAimTo investigate the psychometric properties of the validated Portuguese version of the Brief Illness Perception Questionnaire (Brief‐IPQ) in patients with gingivitis and periodontitis.Material and MethodsThis study enrolled 571 patients with periodontal diseases (PDs) (67 gingivitis and 504 periodontitis cases), in a population‐based epidemiologic survey conducted at the health centres in the South Lisbon Metropolitan Area. Brief‐IPQ, a 9‐item self‐reported scale, reliability was evaluated using Cronbach's alpha. Confirmatory factor analysis (CFA) was used to construct validation. Multigroup analysis tested invariance across gender.ResultsThe Brief‐IPQ showed acceptable reliability (α = .80). Confirmatory factor analysis revealed good model fit (χ2 (16) = 41.236, GFI = 0.982, CFI = 0.985, RMSEA = 0.053). All factors loaded similarly to the original Brief‐IPQ scale, with the exception of the “personal control” domain. Periodontal patients downgrade its illness and likely impact. The “consequences” domain showed significant positive correlations with all factors, except “treatment control” and “understanding” domains. The “concern” and “emotional response” domains had the highest significant correlation. Multigroup analysis findings supported factor invariance across the sex groups.ConclusionThe Brief‐IPQ revealed acceptable reliability, construct factorial validity and invariance across gender. This short instrument may be used as an easily applicable and valuable tool to determine illness perception in patients with PDs.
Expanding the clinical features of autoinflammation and phospholipase Cγ2‐associated antibody deficiency and immune dysregulation by description of a novel patient
Authors: Morán‐Villaseñor E. , Saez‐de‐Ocariz M. , Torrelo A. , Arostegui J.I. , Yamazaki‐Nakashimada M.A. , Alcántara‐Ortigoza M.A. , González‐del‐Angel A. , Velázquez‐Aragón J.A. , López‐Herrera G. , Berrón‐Ruiz L. , García‐Romero M.T. 
Published: August 2019

AbstractBackgroundAutoinflammation and phospholipase Cγ2‐associated antibody deficiency and immune dysregulation (APLAID) is an exceedingly rare monogenic autoinflammatory disease. To date, only five cases have been reported with four distinct pathogenic mutations.ObjectivesWe present a novel case of APLAID, corroborated by molecular analysis, with newly described clinical findings including central nervous system vasculitis (CNSV); and distinctive histopathological characteristics that may expand our knowledge of this rare disease′s phenotype.MethodsThis is a case report presentation of a 3‐year‐old boy, seen at a reference paediatric hospital in Mexico. His parents authorized the use of his clinical information and photographs.ResultsA 3‐day‐old boy presented to the emergency department with a vesiculo‐pustular rash that resolved within 1 week. Two months later, he developed widespread papules and pseudovesicles that evolved into infiltrated plaques. He also had periodical flares of conjunctivitis, diarrhoea and erythematous blistering acral plaques triggered by upper respiratory infections. By the age of 10 months, he experienced seizures and CNSV. Laboratory work‐up showed mild neutropenia, decreased serum levels of immunoglobulins and B‐cell lymphopenia. A skin biopsy revealed a dense, perivascular and interstitial histiocytic and granulomatous infiltrate, with palisading granulomas, and leucocytoclastic vasculitis with karyorrhexis. APLAID syndrome was confirmed by Sanger sequencing of PLCG2 gene [heterozygous genotype LRG_376t1:c.2543T>C or p.(Leu848Pro)].ConclusionsPresence of CNSV has not been previously described in APLAID, however as the number of reported patients with APLAID is very small, it is possible that the overall spectrum of clinical manifestations has not been completely elucidated. The herein identified p.(Leu848Pro) variant was also documented in a Portuguese patient, suggesting that it could be a PLCG2 gene ‘hot‐spot’.
G protein‐coupled receptor 40 expression in human melanoma – correlation with tumour thickness, AJCC stage and survival
Authors: Kleemann J. , Hrgovic I. , Kleimann P. , Ter‐Nedden J. , Glaser M. , Steinhorst K. , Härle K. , Müller J. , Kaufmann R. , Kippenberger S. , Meissner M. 
Published: August 2019

AbstractBackgroundIn melanoma, preclinical data suggest a possible role of polyunsaturated fatty acids inhibiting cell growth. A new target molecule for free fatty acids, the G protein‐coupled receptor GPR40, was identified in melanoma cells.ObjectivesThe aim of this study was to investigate GPR40 expression in human melanocytic tissues and to evaluate its potential as a prognostic marker.Methods and ResultsA total of 114 tissue sections of naevi, primary melanoma and melanoma metastasis were immunohistochemically stained with anti‐GPR40. The staining was evaluated, using the immunoreactivity scoring system. Compared to naevi, primary melanoma and melanoma metastasis showed significantly higher levels of GPR40 (P < 0.05). In primary melanoma, GPR40 expression positively correlated with tumour thickness (P = 0.044) and AJCC level (P = 0.017) and in melanoma metastasis with AJCC level (P = 0.035). Primary melanoma patients with high levels of GPR40 had a significantly poorer overall survival (P = 0.004) and shorter disease‐free survival (0.040).ConclusionThe present study identified GPR40 as a novel target molecule in melanoma. First evidence for a potential role of the receptor in tumour progression and metastases was found, and it could be demonstrated that GPR40 expression is negatively correlated with patient's survival.
Collective aggressiveness limits colony persistence in high‐ but not low‐elevation sites at Amazonian social spiders
Authors: Lichtenstein James L. L. , Fisher David N. , McEwen Brendan L. , Nondorf Daniel T. , Calvache Esteban , Schmitz Clara , Elässer Jana , Pruitt Jonathan N. 
Published: August 2019

AbstractIdentifying the traits that foster group survival in contrasting environments is important for understanding local adaptation in social systems. Here, we evaluate the relationship between the aggressiveness of social spider colonies and their persistence along an elevation gradient using the Amazonian spider,Anelosimus eximius. We found that colonies ofA. eximiusexhibit repeatable differences in their collective aggressiveness (latency to attack prey stimuli) and that colony aggressiveness is linked with persistence in a site‐specific manner. Less aggressive colonies are better able to persist at high‐elevation sites, which lack colony‐sustaining large‐bodied prey, whereas colony aggression was not related to chance of persistence at low‐elevation sites. This suggests that low aggressiveness promotes colony survival in high‐elevation, prey‐poor habitats, perhaps via increased tolerance to resource limitation. These data reveal that the collective phenotypes that relate to colony persistence vary by site, and thus, the path of social evolution in these environments is likely to be affected.
Prevalence and risk factors for postpartum urinary retention after vaginal delivery in Japan: A case‐control study
Authors: Kawasoe Izumi , Kataoka Yaeko 
Published: August 2019

AbstractAimThis study aimed to clarify the prevalence and risk factors of postpartum urinary retention after vaginal delivery. It also described the healing process of women who had postpartum urinary retention.MethodsIn this case‐control study, 77 women who had postpartum urinary retention were matched by age and parity with 385 women as controls. Data were analyzed by conditional logistic regression analysis. Data were collected from the women in the case group regarding their healing process and conditions for urinary retention (overt or covert urinary retention).ResultsThe prevalence of postpartum urinary retention was 1.2%. The adjusted odds ratio and the 95% confidence intervals for risk factors were as follows: epidural analgesia 4.72, 95% CI 2.38, 9.39; episiotomy 2.68, 95% CI 1.40, 5.13; length of second stage of labor 1.85, 95% CI 0.98, 3.49; labor augmentation 1.78, 95% CI 0.90, 3.51; instrument delivery 0.96, 95% CI 0.43, 2.17; and Kristeller maneuver 0.93, 95% CI 0.37, 2.37. Among 59 women with overt urinary retention, 29 (49.2%) transitioned to covert urinary retention within 10 days after delivery. More than half of the women were normal within 72 hr, but there were five women whose urinary retention did not resolve 11 days following delivery.ConclusionsThe statistically significant risk factors for postpartum urinary retention were epidural analgesia and episiotomy. Initiatives for the prevention and management of postpartum urinary retention are necessary.
Injury‐preconditioning secretome of umbilical cord mesenchymal stem cells amplified the neurogenesis and cognitive recovery after severe traumatic brain injury in rats
Authors: Liu Xiao‐Yin , Wei Meng‐Guang , Liang Jun , Xu Hai‐Huan , Wang Jing‐Jing , Wang Jing , Yang Xi‐Ping , Lv Fang‐Fang , Wang Ke‐Qiang , Duan Jing‐Hao , Tu Yue , Zhang Sai , Chen Chong , Li Xiao‐Hong 
Published: August 2019

AbstractTraumatic brain injury (TBI) is a dominant cause of death and permanent disability worldwide. Although TBI could significantly increase the proliferation of adult neural stem cells in the hippocampus, the survival and maturation of newborn cells is markedly low. Increasing evidence suggests that the secretome derived from mesenchymal stem cells (MSCs) would be an ideal alternative to MSC transplantation. The successive and microenvironmentally responsive secretion in MSCs may be critical for the functional benefits provided by transplanted MSCs after TBI. Therefore, it is reasonable to hypothesize that the signaling molecules secreted in response to local tissue damage can further facilitate the therapeutic effect of the MSC secretome. To simulate the complex microenvironment in the injured brain well, we used traumatically injured brain tissue extracts to pretreat umbilical cord mesenchymal stem cells (UCMSCs) in vitro and stereotaxically injected the secretome from traumatic injury‐preconditioned UCMSCs into the dentate gyrus of the hippocampus in a rat severe TBI model. The results revealed that compared with the normal secretome, the traumatic injury‐preconditioned secretome could significantly further promote the differentiation, migration, and maturation of newborn cells in the dentate gyrus and ultimately improve cognitive function after TBI. Cytokine antibody array suggested that the increased benefits of secretome administration were attributable to the newly produced proteins and up‐regulated molecules from the MSC secretome preconditioned by a traumatically injured microenvironment. Our study utilized the traumatic injury‐preconditioned secretome to amplify neurogenesis and improve cognitive recovery, suggesting this method may be a novel and safer candidate for nerve repair.
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Cover Image for this issue: doi: 10.1111/jnc.14741
The types of caregiving reactions experienced by the older spouse caregivers
Authors: Aloweni Fazila , Doshi Kinjal , Fook‐Chong Stephanie , Malhotra Rahul , Østbye Truls 
Published: August 2019

AbstractAimsTo examine factors associated with the four types of caregiver reactions according to the modified Caregiver Reaction Assessment (mCRA) and assess the differences in the narrative assessment from spouse caregivers between the high‐positive and high‐negative caregiver reactions.BackgroundThere is a limited understanding of the factors contributing to positive and negative reactions among older spouse caregivers with chronic illnesses. Narrative assessment from spouse caregivers has not been studied before.DesignThe study design was a paired‐sample, mixed‐method survey design. Data were collected from spouse caregivers (≥55 years old) and care‐recipients in one medical institute from February 2017–December 2017. This manuscript used STROBE checklist to ensure complete reporting.MethodsDemographic, socioeconomic, Frailty Index, perceived stress, and quality of life data were gathered from caregiver dyads. mCRA, relationship, and life satisfaction data were collected from caregivers. mCRA identified the four types of caregiver reactions: (a) high‐positive, low‐negative; (b) high‐positive, high‐negative; (c) low‐positive, high‐negative; and (d) low‐positive, low‐negative. A qualitative interview was conducted to understand the differences in the narrative and choice of words used to describe caregiving experience.ResultsSeventy‐five caregiver dyads were recruited. Total perceived stress was found to be negatively associated with high‐positive, low‐negative caregiver reaction (baseline category: low‐positive, high‐negative) by multinomial logistic regression. Content analyses showed that low‐positive and high‐negative caregivers used words that implied a lack of volition. Caregivers with positive experience viewed caregiving as a responsibility; the opposite viewed it as having ‘no choice’.ConclusionsPerceived stress is an important indicator of caregiver reactions. Words used when describing caregiving experiences can potentially depict the spouse caregivers' current state of being as a caregiver.Relevance to clinical practiceSpouse caregiver's narrative of their caregiving experience may provide easy and quick insights if interventions are needed. Early identification of negative reactions will allow for prompt interventions in mitigating caregivers' stress.
Establishment of reference intervals for maternal blood and umbilical cord blood procalcitonin in healthy Chinese women in late pregnancy
Authors: Ma Yan , Shao Minfang , Shao Xiaonan , Wang Yuetao , Chen Xueqin 
Published: August 2019

AbstractAimTo establish reference intervals (RIs) for maternal blood and umbilical cord blood procalcitonin (PCT) in healthy Chinese women in late pregnancy.MethodsOne hundred and twenty‐seven healthy Chinese women in late pregnancy, including 70 vaginal deliveries and 57 cesarean section deliveries, were retrospectively analyzed. These pregnant women gave birth to 58 male infants and 69 female infants. Another 127 age‐matched healthy women who were not pregnant were enrolled as the control group. PCT levels in maternal blood, umbilical cord blood and control blood were determined using electrochemiluminescence immunoassay. The RIs of PCT were defined using an intermediate 95% interval.ResultsThe RIs for maternal blood and umbilical cord blood PCT were 0.020–0.075 ng/mL and 0.020–0.159 ng/mL, respectively. The cord blood PCT level was not significantly different between different delivery methods (P > 0.05). In contrast, the umbilical cord blood PCT in female newborns was higher than that in male newborns (0.088 ± 0.046 ng/mL vs 0.072 ± 0.030 ng/mL, P < 0.05).ConclusionMaternal blood and umbilical cord blood PCT of Chinese women in late pregnancy have different RIs, and umbilical cord blood PCT level is affected by the gender of newborns.
Neuroprotective Effects of Rasagiline in Parkinson's Disease: A Regional Cerebral Blood Flow Study
Authors: Im Jooyeon Jamie , Jeong Hyeonseok , Chung Yong‐An , Park Jong‐Sik , Heo Youngje , Oh Jin Kyoung , Song In‐Uk 
Published: August 2019

ABSTRACTBACKGROUND AND PURPOSEDespite accumulating evidence for the clinical efficacy and neuroprotective properties of rasagiline in Parkinson's disease (PD), effects of rasagiline on brain perfusion in PD patients have not been elucidated. The present study aimed to investigate the effects of rasagiline on regional cerebral blood flow (rCBF) in patients with PD using single‐photon emission computed tomography (SPECT).METHODSA total of 44 PD patients were recruited and treated with dopamine agonist, either alone or in combination with levodopa. Twenty‐two of these patients (referred to as the rasagiline group) additionally received rasagiline (1 mg/day). All patients underwent brain SPECT scans and clinical assessments at baseline and follow‐up visits. The mean follow‐up period was 2.2 years. Changes in rCBF were compared between the rasagiline group and the comparison group in a voxel‐wise manner.RESULTSAnnual change in Unified Parkinson's Disease Rating Scale motor score was lower in the rasagiline group compared to the comparison group (P = .01). A significant group‐by‐time interaction effect on rCBF was found in the right precuneus (P = .001), where rCBF was decreased in the comparison group and remained stable in the rasagiline group.CONCLUSIONSOur results show that adjunctive rasagiline treatment had beneficial effects on perfusion in the precuneus of PD patients, suggesting potential neuroprotective effects.