bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ketone ester supplementation blunts overreaching symptoms during endurance training overload
Authors: Poffé Chiel , Ramaekers Monique , Van Thienen Ruud , Hespel Peter 
Published: May 2019

Key points
Overload training is required for sustained performance gain in athletes (functional overreaching). However, excess overload may result in a catabolic state which causes performance decrements for weeks (non‐functional overreaching) up to months (overtraining).
Blood ketone bodies can attenuate training‐ or fasting‐induced catabolic events. Therefore, we investigated whether increasing blood ketone levels by oral ketone ester (KE) intake can protect against endurance training‐induced overreaching.
We show for the first time that KE intake following exercise markedly blunts the development of physiological symptoms indicating overreaching, and at the same time significantly enhances endurance exercise performance.
We provide preliminary data to indicate that growth differentiation factor 15 (GDF15) may be a relevant hormonal marker to diagnose the development of overtraining.
Collectively, our data indicate that ketone ester intake is a potent nutritional strategy to prevent the development of non‐functional overreaching and to stimulate endurance exercise performance.
AbstractIt is well known that elevated blood ketones attenuate net muscle protein breakdown, as well as negate catabolic events, during energy deficit. Therefore, we hypothesized that oral ketones can blunt endurance training‐induced overreaching. Fit male subjects participated in two daily training sessions (3 weeks, 6 days/week) while receiving either a ketone ester (KE, n = 9) or a control drink (CON, n = 9) following each session. Sustainable training load in week 3 as well as power output in the final 30 min of a 2‐h standardized endurance session were 15% higher in KE than in CON (both P < 0.05). KE inhibited the training‐induced increase in nocturnal adrenaline (P < 0.01) and noradrenaline (P < 0.01) excretion, as well as blunted the decrease in resting (CON: −6 ± 2 bpm; KE: +2 ± 3 bpm, P < 0.05), submaximal (CON: −15 ± 3 bpm; KE: −7 ± 2 bpm, P < 0.05) and maximal (CON: −17 ± 2 bpm; KE: −10 ± 2 bpm, P < 0.01) heart rate. Energy balance during the training period spontaneously turned negative in CON (−2135 kJ/day), but not in KE (+198 kJ/day). The training consistently increased growth differentiation factor 15 (GDF15), but ∼2‐fold more in CON than in KE (P < 0.05). In addition, delta GDF15 correlated with the training‐induced drop in maximal heart rate (r = 0.60, P < 0.001) and decrease in osteocalcin (r = 0.61, P < 0.01). Other measurements such as blood ACTH, cortisol, IL‐6, leptin, ghrelin and lymphocyte count, and muscle glycogen content did not differentiate KE from CON. In conclusion, KE during strenuous endurance training attenuates the development of overreaching. We also identify GDF15 as a possible marker of overtraining.
What are the barriers and challenges faced by adolescents when searching for sexual health information on the internet? Implications for policy and practice from a qualitative study
Authors: Patterson Susan Patricia , Hilton Shona , Flowers Paul , McDaid Lisa M 
Published: May 2019

ObjectivesAs sexual health information is increasingly presented digitally, and adolescents are increasingly seeking sexual health information on the internet, it is important to explore the challenges presented by this developing source of information provision. This study examined the key barriers and challenges faced by young people when accessing and using sexual health information online.MethodsA novel qualitative approach was used which combined paired interviews with real-time online activities. A purposive sample of 49 young people aged between 16 and 19 years and diverse in terms of gender, sexuality, religion and socio-demographic background were recruited from areas across Scotland. Data analysis comprised framework analysis of conversational data (including pair interactions), descriptive analysis of observational data, and data integration.ResultsThis study highlighted practical and socio-cultural barriers to engagement with online sexual health content. Key practical barriers included difficulty filtering overabundant content; limited awareness of specific, relevant, trusted online sources; difficulties in finding locally relevant information about services; and difficulties in navigating large organisations’ websites. Key socio-cultural barriers included fear of being observed; wariness about engaging with visual and auditory content; concern about unintentionally accessing sexually explicit content; and reticence to access sexual health information on social networking platforms or through smartphone applications. These practical and socio-cultural barriers restricted access to information and influenced searching practices.ConclusionThis study provides insights into some of the key barriers faced by young people in accessing and engaging with sexual health information and support online. Reducing such challenges is essential. We highlight the need for sexual health information providers and intervention developers to produce online information that is accurate and accessible; to increase awareness of and promote reliable, accessible sources; and to be sensitive to young people’s concerns about ‘being seen’ accessing sexual health information regarding audio-visual content and platform choice.
Chapter 12 A 251 Ma diorite clast from a Maitai Group conglomerate and a
c.
259 Ma microdiorite sill intruding the Productus Creek Group, Southland, New Zealand: note
Authors: Mortimer N. , Turnbull R. E. , Robertson A. H. F. , Campbell H. J. 
Published: May 2019

Abstract
We present the results of U–Pb dating of zircons of two Late Permian igneous rocks from the Dun Mountain–Maitai and Brook Street terranes of New Zealand's South Island. A conglomerate clast of hornblende diorite from the Early–Middle Triassic Stephens Subgroup, Maitai Group, gives an age of 251.1 ± 1.6 Ma. A sample of hypabyssal andesite–microdiorite (Weetwood Formation) that intrudes the Late Permian Productus Creek Group of the Brook Street Terrane gives an age of 258.8 ± 7.9 Ma. The intermediate and subalkaline geochemistry of the two samples is not distinctive of specific tectonic settings, but their ages match plutons of the I-type, subduction-related Longwood Suite of the nearby Median Batholith. Assuming that correlation with the Longwood Suite is correct, the Weetwood sample increases the known areal extent of intrusion of the Longwood Suite; and the Stephens Subgroup Formation clast is consistent with a detrital link between Gondwana and the Dun Mountain–Maitai Terrane by the Middle Triassic. However, because of uncertainties regarding the timing of magmatism along other parts of the Gondwana margin, the data in this paper do not establish any specific provenance links.
Chapter 4 Geological development and regional significance of an oceanic magmatic arc and its sedimentary cover: Permian Brook Street Terrane, South Island, New Zealand
Authors: Robertson Alastair H. F. , Palamakumbura Romesh 
Published: May 2019

Abstract

The
c.
450 km-long Brook Street Terrane (pre-Alpine Fault displacement) sheds light on processes of arc magmatism and related sedimentation. A very thick (up to 15 km) succession accumulated south of the Alpine Fault in the Takitimu Mountains during the Early Permian. Predominant arc-flank talus is intercalated with basic extrusive and intrusive igneous rocks. Volcaniclastic sediments mainly accumulated by mass-flow and turbidity current processes. The sediments were mostly derived from differentiated, arc-core, basaltic–andesitic rocks, contrasting with less evolved arc-flank flows and minor intrusions. Some igneous rocks are mildly enriched, supporting an extensional back-arc setting. After volcanism ended, Middle–Late Permian mixed carbonate–volcaniclastic gravity-flow deposits were derived from a non-exposed carbonate platform. Other volcanogenic successions in the south (Bluff, Riverton) represent smaller eruptive centres. In contrast, north of the Alpine Fault (e.g. Nelson), volcanism began with mostly felsic tuffaceous gravity-flow deposits, followed by extrusion/intrusion of clinopyroxene-rich, primitive magmas, related to arc rifting, and ended with an accumulation of a mixed basic–felsic volcaniclastic forearc apron. Taking account of regional comparisons, the Early Permian arc is interpreted as having formed adjacent to Gondwana (on accreted or trapped oceanic lithosphere), whereas the lithologies north of the Alpine Fault represent contrasting Late Permian continental arc magmatism.
Chapter 11 Geochemistry used to infer source characteristics and provenance of mudrocks of the Permian–Triassic Maitai Group and the associated Patuki Melange, South Island, New Zealand
Authors: Palamakumbura Romesh , Robertson Alastair H. F. 
Published: May 2019

Abstract
Chemical and mineralogical evidence is reported, first for mudrocks from the Mid-Permian–Mid-Triassic Maitai Group and, secondly, for Late Permian(?) mudrocks from the structurally underlying Patuki Melange. Weathering and alteration indices indicate increased source weathering and aluminosilicate input stratigraphically upwards in the Maitai Group. The Maitai Group exhibits an upward change from a relatively enriched continental magmatic arc source (and related country rocks) during the Late Permian, to a relatively depleted continental magmatic arc source (and related country rocks) during the Triassic. The melange mudrocks have a similar provenance to the Late Permian mudrocks of the Maitai Group. The melange mudrocks are, however, generally less altered, probably because of additional, local, ophiolite-related input. Red iron-rich mudrocks accumulated widely in two Triassic Maitai Group formations and also locally in the Patuki Melange. The iron oxide was derived by continental weathering under warm conditions, and then accumulated relatively slowly under oxidizing seafloor conditions. The chemical evidence, as a whole, indicates sources for all of the mudrocks similar to the Median Batholith and associated country rocks, or non-exposed equivalents along the SE Gondwana active continental margin. Accumulation took place during a change from an icehouse to a hothouse world.
Chapter 10 Sedimentary geochemistry used to infer the provenance of Permian–Triassic marine sandstones related to the SE Gondwana active continental margin, South Island, New Zealand
Authors: Robertson Alastair H. F. , Palamakumbura Romesh 
Published: May 2019

Abstract
Major, trace and rare earth element data for sandstones and conglomerates from the Mid-Permian–Mid-Triassic Maitai Group are compared with other tectonostratigraphic units, using discrimination diagrams and comparisons with potential source terranes. Maitai Group sandstones reveal a mainly ophiolitic–oceanic-arc source during the Mid-Permian, followed by a mixed continental margin-arc–terrigenous source during the Late Permian. Latest Permian–Early Triassic sandstones mainly came from little-evolved continental margin-arc extrusives, tending to more evolved (but variable) during the Triassic. Source volcanism of the Murihiku Terrane sandstones was magmatically evolved relative to the Maitai Group generally (except during the Late Triassic). The Maitai Group and Murihiku Terrane are restored as proximal and more distal parts, respectively, of the SE Gondwana forearc basin. The localized Willsher Group shows some Maitai Group affinities. Sandstones in two melanges that formed in an outer forearc–subduction trench setting mainly indicate a mixed terrigenous–continental margin-arc source, similar to the Late Permian Maitai Group. The Caples Terrane, a Triassic accretionary prism, received detritus from little-evolved, to evolved continental margin-arc volcanics and terrigenous sources. Much of the arc-related material in all units is compatible with derivation from the latest Permian–Triassic Median Batholith, or a lateral equivalent along the SE Gondwana active margin.
Chapter 13 Permian–Triassic felsic tuffs in South Island, New Zealand: significance for oceanic and active continental margin subduction
Authors: Robertson Alastair H. F. , Palamakumbura Romesh , Campbell Hamish J. 
Published: May 2019

Abstract
Felsic tuffs play an important role in the Permian–Triassic geology of the Eastern Province in South Island. In the Brook Street Terrane, primary felsic tuff is minor in the south (e.g. Takitimu Mountains) but abundant in the north (Grampian Formation, Nelson area). Felsic fallout tuff dominates one interval of the Maitai Group (Early Triassic Kiwi Burn Formation), south of the Alpine Fault, but is otherwise mainly redeposited by gravity flows. The Murihiku Terrane is characterized by two main intervals of felsic fallout tuff, the Middle Triassic Gavenwood Tuffs and the Late Triassic Bare Hill Tuff Zone, south of the Alpine Fault (e.g. Hokonui Hills and south Otago coast). Counterparts north of the Alpine Fault (Richmond Group) are mainly reworked, with terrigenous admixtures. Tuffaceous sediments are also abundant in the late Middle–early Late Triassic Willsher Group (south Otago coast). Based on combined field, petrographical, semi-quantitative X-ray diffraction (XRD) and chemical evidence, the felsic tuffs of the Brook Street Terrane in the south are interpreted as small-scale eruptions of fractionated oceanic-arc-type magmas. In contrast, the Triassic felsic tuffs of the Murihiku Terrane, Willsher Group and Maitai Group erupted violently and episodically in proximal to distal segments of the SE Gondwana continental margin.
Chapter 3 Biostratigraphic age review of New Zealand's Permian–Triassic central terranes
Authors: Campbell Hamish J. 
Published: May 2019

Abstract
This contribution considers the fossil content of the three Eastern Province ‘central’ terranes discussed within this Memoir, namely the Brook Street Terrane, the Dun Mountain–Maitai Terrane and the Murihiku Terrane, and reviews the evidence and/or arguments for the current interpretation of their age ranges as determined from fossils. It also briefly considers the Permian–Triassic record of the Western Province. There has been limited new palaeontological discovery in the past few decades but there has been significant new taxonomic and biostratigraphic analysis of New Zealand Permian faunas in light of new research in eastern Australia. This enables refinement of age correlations and greater confidence in the age significance of the New Zealand Permian record.
Chapter 15 Construction of a Paleozoic–Mesozoic accretionary orogen along the active continental margin of SE Gondwana (South Island, New Zealand): summary and overview
Authors: Robertson Alastair H. F. , Campbell Hamish J. , Johnston Mike R. , Palamakumbra Romesh 
Published: May 2019

Abstract

The Western Province is a fragment of the
c.
500 Ma SE Gondwana active continental margin. The Eastern Province is a terrane assemblage, which is partly stitched by the Median Batholith. Fragments of the batholith are preserved in the adjacent Drumduan and Brook Street terranes. Permian arc magmatism of the Brook Street Terrane involved both oceanic and continental margin settings. The Permian (
c.
285–275 Ma) supra-subduction zone Dun Mountain ophiolite records subduction initiation and subsequent oceanic-arc magmatism. The Permian Patuki and Croisilles melanges represent detachment of the ophiolitic forearc and trench–seamount accretion. The Murihiku Terrane, a proximal continental margin forearc basin, received detritus from the Median Batholith (or equivalent). The south coast, Early–Late Triassic Willsher Group is another proximal forearc basin unit. The sediments of the Dun Mountain–Maitai Terrane (Maitai basin) represent a distal segment of a continental margin forearc basin. The Caples Terrane is a mainly Triassic trench accretionary complex, dominantly sourced from a continental margin arc, similar to the Median Batholith. The outboard (older) Torlesse and Waipapa terranes are composite subduction complexes. Successively more outboard terranes may restore farther north along the SE Gondwana continental margin. Subduction and terrane assembly were terminated by collision (at
c.
100 Ma), followed by rifting of the Tasman Sea Basin.
Diaphragm neuromuscular transmission failure in aged rats
Authors: Fogarty Matthew J. , Gonzalez Porras Maria A. , Mantilla Carlos B. , Sieck Gary C. 
Published: May 2019

In aging Fischer 344 rats, phrenic motor neuron loss, neuromuscular junction abnormalities, and diaphragm muscle (DIAm) sarcopenia are present by 24 mo of age, with larger fast-twitch fatigue-intermediate (type FInt) and fast-twitch fatigable (type FF) motor units particularly vulnerable. We hypothesize that in old rats, DIAm neuromuscular transmission deficits are specific to type FInt and/or FF units. In phrenic nerve/DIAm preparations from rats at 6 and 24 mo of age, the phrenic nerve was supramaximally stimulated at 10, 40, or 75 Hz. Every 15 s, the DIAm was directly stimulated, and the difference in forces evoked by nerve and muscle stimulation was used to estimate neuromuscular transmission failure. Neuromuscular transmission failure in the DIAm was observed at each stimulation frequency. In the initial stimulus trains, the forces evoked by phrenic nerve stimulation at 40 and 75 Hz were significantly less than those evoked by direct muscle stimulation, and this difference was markedly greater in 24-mo-old rats. During repetitive nerve stimulation, neuromuscular transmission failure at 40 and 75 Hz worsened to a greater extent in 24-mo-old rats compared with younger animals. Because type IIx and/or IIb DIAm fibers (type FInt and/or FF motor units) display greater susceptibility to neuromuscular transmission failure at higher frequencies of stimulation, these data suggest that the age-related loss of larger phrenic motor neurons impacts nerve conduction to muscle at higher frequencies and may contribute to DIAm sarcopenia in old rats.NEW & NOTEWORTHY Diaphragm muscle (DIAm) sarcopenia, phrenic motor neuron loss, and perturbations of neuromuscular junctions (NMJs) are well described in aged rodents and selectively affect FInt and FF motor units. Less attention has been paid to the motor unit-specific aspects of nerve-muscle conduction. In old rats, increased neuromuscular transmission failure occurred at stimulation frequencies where FInt and FF motor units exhibit conduction failures, along with decreased apposition of pre- and postsynaptic domains of DIAm NMJs of these units.
Functional anatomy of extraocular muscles during human vergence compensation of horizontal heterophoria
Authors: Demer Joseph L. , Clark Robert A. 
Published: May 2019

We employed magnetic resonance imaging to quantify human extraocular muscle (EOM) contractility during intermittent convergent and divergent strabismus with each eye viewing monocularly at 20 cm compared with centered target fusion. Contractility, indicated by posterior partial volume change, was analyzed in transverse rectus and in medial and lateral superior oblique (SO) muscle compartments. In five subjects with intermittent esotropia, abduction of the deviated eye to monocular target fixation was associated with significant whole lateral rectus (LR) contraction, but with medial rectus (MR) relaxation that was significantly greater in the superior than inferior compartment. Esotropic eye abduction to binocular fusion was associated with similar relaxation in the two MR compartments, but with greater contraction in the LR’s superior than inferior compartment. The whole diverging eye SO muscle relaxed. In three subjects with intermittent exotropia, converging eye fusional adduction was associated with significant whole LR relaxation and with MR contraction attributable to significantly greater contraction in the superior than inferior compartment. In adduction of the exotropic eye to monocular target fixation but not fusional adduction, the whole SO exhibited significant relaxation. Rectus pulley positions were not significantly altered by fusion of either form of intermittent strabismus. Globe rotational axis was eccentric in intermittent strabismus, rolling the eye so that rectus EOM lever arms facilitated vergence. These results confirm, and extend to fusion of intermittent horizontal strabismus, differential compartmental function in horizontal rectus EOMs and suggest a novel role for the SO in compensation of both intermittent esotropia and exotropia. NEW & NOTEWORTHY Disjunctive eye movements normally permit binocular fixation in near visual space but also compensate for mechanical imbalances in binocular alignment developing over the life span. Magnetic resonance imaging of the extraocular muscles demonstrates important differential function in muscle compartments during compensation of large-angle intermittent convergent and divergent strabismus in humans. Eye translation during rotation also enhances vergence compensation of intermittent strabismus.
Action-based attention in Drosophila melanogaster
Authors: Frighetto Giovanni , Zordan Mauro A. , Castiello Umberto , Megighian Aram 
Published: May 2019

The mechanism of action selection is a widely shared fundamental process required by animals to interact with the environment and adapt to it. A key step in this process is the filtering of the “distracting” sensory inputs that may disturb action selection. Because it has been suggested that, in principle, action selection may also be processed by shared circuits in vertebrate and invertebrates, we wondered whether invertebrates show the ability to filter out “distracting” stimuli during a goal-directed action, as seen in vertebrates. In this experiment, action selection was studied in wild-type Drosophila melanogaster by investigating their reaction to the abrupt appearance of a visual distractor during an ongoing locomotor action directed to a visual target. We found that when the distractor was present, flies tended to shift the original trajectory toward it, thus acknowledging its presence, but they did not fully commit to it, suggesting that an inhibition process took place to continue the unfolding of the planned goal-directed action. To some extent flies appeared to take into account and represent motorically the distractor, but they did not engage in a complete change of their initial motor program in favor of the distractor. These results provide interesting insights into the selection-for-action mechanism, in a context requiring action-centered attention, that might have appeared rather early in the course of evolution. NEW & NOTEWORTHY Action selection and maintenance of a goal-directed action require animals to ignore irrelevant “distracting” stimuli that might elicit alternative motor programs. In this study we observed, in Drosophila melanogaster, a top-down mechanism inhibiting the response toward salient stimuli, to accomplish a goal-directed action. These data highlight, for the first time in an invertebrate organism, that the action-based attention shown by higher organisms, such as humans and nonhuman primates, might have an ancestral origin.