bluuebunny/crossref_metadata_2025_split huggingface dataset:
100% Sustained Virological Response and Fibrosis Improvement in Real-Life Use of Direct Acting Antivirals in Genotype-1b Recurrent Hepatitis C following Liver Transplantation
Authors: Iacob Speranta , Cerban Razvan , Pietrareanu Corina , Ester Carmen , Iacob Razvan , Gheorghe Cristian , Popescu Irinel , Gheorghe Liana 
Published: June 2018

Background: Nowadays, interferon-free therapy using new direct-acting antivirals (DAA) has dramatically increased the cure rate across different HCV-infected patient populations, including groups traditionally viewed as difficult-to-treat (patients with co-infections, cirrhosis and liver transplant – LT recipients) with marked improvement in safety and tolerability.Aim: To present our experience with DAA therapy in LT recipients, as well as to compare pre- and posttreatment liver stiffness (LS) and noninvasive fibrosis scores.Methods: Our cohort consisted of 89 patients with genotype 1 (GT1) recurrent hepatitis C after LT.Seventy six patients received ombitasvir/paritaprevir/ritonavir+dasabuvir+ribavirin and 13 sofosbuvir/ ledipasvir±ribavirin. Fibroscan®, FIB4 and APRI scores were performed in all patients before and 12 weeks after DAA therapy.Results: We analyzed 45 (50.5%) males and 44 (49.5%) females with a mean age of 55±7.7 years. Median time since LT was 20.9 months. At baseline, 53 (59.6%) of patients had severe necroinflammation at Fibromax®; advanced fibrosis (F3, F4) was encountered in 35 (39.4%) and grade 3 steatosis in 33 (37.1%) of LT recipients.End of therapy (EOT) virological response (VR) was 100%. Sustained virological response 12 weeks after therapy (SVR12) was 97.7% in the intention-to-treat analysis and 100% in per protocol analysis. There was a significant improvement in LS between antiviral therapy initiation and SVR12: 11.9±1.05kPa vs 8.8±0.6kPa (p<0.0001), as well as in APRI (2.7±0.3 vs 0.4±0.05, p<0.0001) and FIB4 (4.6±0.5 vs 2.5±0.2, p<0.0001) scores.Conclusion: In HCV positive recipients, DAA regimens are highly effective and safe. A significant decrease of LS by transient elastography and fibrosis non-invasive scores can be observed after successful therapy.
Clinical profile of patients with intertrochanteric fractures of hip attending tertiary care hospital
Authors: Dasari Srivanth , Baig Mirza Shahrukh , Nippuleti Anoop , Rudraraju Raviteja 
Published: June 2018

<p class="abstract"><strong>Background:</strong> The hip joint is ball and socket joint. In weight bearing the pressure forces are transmitted to the head and neck of the femur at an angle of 165 degrees to 170 degrees regardless of position of pelvis. The plane of the force coincides with strongly developed trabeculae that lie in the medial portion of the femoral neck and extend upwards through the supero-medial aspect of the femoral head. These trabeculae are in line with similar pressure trabeculae that start at acetabulum and run upwards and medial to sacro-iliac joint.</p><p class="abstract"><strong>Methods:</strong> After the patient with intertrochanteric fracture was admitted to our hospital, all the necessary clinical details were recorded in the proforma prepared for this study. After the completion of the hospital treatment patients were discharged and called for follow-up to outpatient department at regular intervals (6 weeks, 12 weeks, 6 months, 12 months) for clinical and radiological evaluation.<strong></strong></p><p class="abstract"><strong>Results:</strong> The most common age group was in the range of 60 to 70 yrs. Most common mode of injury was trivial fall in this series. 56% of the patients having type II BOYD and GRIFFIN fracture.</p><p><strong>Conclusions:</strong> Most common mode of injury in young patients is the road traffic accident while most common mode of injury in older patients is the simple fall (domestic fall). </p>
A study on correlation between arthroscopy and MRI in internal derangement of knee
Authors: Nippuleti Anoop , Rudraraju Raviteja , Dasari Srivanth , Baig Mirza Shahrukh 
Published: June 2018

<p class="abstract"><strong>Background:</strong> The knee joint is a common site of injury, mainly due to trauma, repetitive activities and sports activities. Multiple imaging modalities are currently used to evaluate pathologic conditions of the knee. Magnetic resonance imaging has a better soft tissue contrast and multi planar slice capability, which has revolutionized and has become the ideal modality for imaging complex anatomy of the knee joint. Another advanced modality in the management of IDK is arthroscopy, which can be used in its dual mode, either as diagnostic and/or as therapeutic tool.</p><p class="abstract"><strong>Methods:</strong> Cases were taken according to inclusion and exclusion criteria i.e., patients with knee problems more than 6weeks old, with symptoms of locking of knee, patients with undiagnosed knee pain and knee injury. Only patients between 15-50 years are included in the study. Patients with signs of infection, with osteoarthritis, ankylosis, and patients on ATT were excluded from the study.<strong></strong></p><p class="abstract"><strong>Results:</strong> In our study of 25 cases, there were 20 male and 5 female patients with age ranging from 15 years to 50 years with most patients in between 21-30 years. 11 cases admitted were sport injuries, 14 had motor vehicle accidents. Right side being more common side affected.</p><p><strong>Conclusions:</strong> In conclusion the present study supports that clinical diagnosis is of primary necessity and MRI is additional diagnosing tool for IDK. </p>
Manejo endodôntico de dentes reimplantados: revisão de literatura
Authors: Jesus Gustavo Simoni de , Ghiggi Paula Cristine , Klassmann Larissa Magnus 
Published: June 2018

O reimplante dentário destaca-se como um procedimento conservador, sendo a conduta não-protética que pode ser realizada em casos de avulsão, evitando sequelas estéticas, funcionais e psicológicas junto ao paciente. Para controlar os processos reabsortivos que se desencadeiam devido a lesão no ligamento periodontal, o tratamento endodôntico se faz necessário. Objetivo: apresentar uma revisão de literatura sobre o manejo endodôntico de dentes reimplantados, elucidando os aspectos clínicos, radiográficos e fisiológicos envolvidos no processo e, também, confeccionar um guia de consulta para prática clínica. Conclusão: O reimplante dentário auxilia no aspecto psicológico decorrente da perda dentária, sendo a endodontia uma etapa fundamental no processo. Ao final do tratamento Endodôntico de um dente re-implantado, com uso da medicação intracanal adeaquada, a saber hidróxido de cálcio, espera-se um dente clinicamente assintomático e radiograficamente ausência de sinais de reabsorção e lesão apical. Contudo, o acompanhamento clínico e radiográfico do paciente deve ser feito por pelo menos cinco anos.
Avaliação das condições de conforto visual em edificação tombada com novo uso: estudo de caso do Casarão 2, Pelotas/RS
Authors: Silva Mariana Estima , Vianna Saionara , Medvedovsky Nirce , Torres Ariela , Salamoni Isabel 
Published: June 2018

Estudos referentes à utilização de edificações históricas por novos usos são muito relevantes atualmente, visto que tratam de temas como economia de matéria-prima e conservação de legados culturais. O processo de retrofit resume-se em ações de restauro com inserção de um novo uso ao prédio. Este trabalho teve como objetivo analisar se as condições de conforto lumínico são satisfatórias em ambientes de uma edificação tombada, que passou por retrofit, em relação a seu novo uso, o de escritórios. A fim de alcançar o objetivo da pesquisa, foram escolhidos dois ambientes para estudo, com base em técnicas de walkthrough e levantamento de arquivo. Nesses ambientes foram realizadas medições lumínicas com luxímetros e aplicação de questionários com os usuários. A partir dos métodos quantitativos e qualitativos de pesquisa foi possível alcançar e comparar os resultados, que verificaram a não observância das condições de conforto lumínico durante maior parte do dia. Sendo assim, é possível dizer que para estes ambientes, o novo uso não satisfaz as condições de conforto visual dos usuários, ou seja, o processo de retrofit não atingiu seus objetivos por completo. Também é possível afirmar que o processo de conservação visou apenas a manutenção das características construtivas nestes ambientes.
HAK ASASI MANUSIA: Perspektif Islam
Authors: Mahmudi Zainul 
Published: June 2018

<p>Along with the advancement of human civilization, conversations concerning human rights issues will not subside in time, because the parameters of a civilized nation is if a civilization has been able to put people in proportion, can "humanize" humans. Human rights are of the utmost importance, because human beings can be real human beings if their basic rights are fulfilled and guaranteed after fulfilling their obligations. The denial of human rights implies the denial of human existence which Allah says is used as khalifah fil al ardh. In order to support the universality of Islam and the position of Islam as rahmatan Iil Alamin, the Koran regulates all aspects of human life in all its deeds, both the deeds of the heart and the physical deeds, whether in relation to the faith, ethics, and practical both governing relationships between individuals and individuals, with society, individuals with the state, individuals with the environment, and individuals with their God.</p><p> </p><p>Seiring dengan kemajuan peradaban manusia, perbincangan yang menyangkut permasalahan hak asasi manusia tidak akan surut tertelan zaman, karena parameter suatu bangsa yang beradab adalah apabila suatu peradaban telah dapat mendudukkan manusia secara proporsional, bisa "memanusiakan" manusia. Hak asasi manusia menjadi sangat penting, karena manusia bisa menjadi manusia yang sebenamya apabila hak asasinya telah terpenuhi dan terjamin setelah menunaikan kewajibannya. Pengingkaran terhadap hak asasi manusia berarti pengingkaran terhadap eksistensi manusia yang kata Allah dijadikan sebagai <em>khalifah fil al ardh.</em> Dalam rangka mendukung universalitas Islam dan posisi Islam sebagai rahmatan Iil Alamin, Quran mengatur semua aspek kehidupan manusia dalam segala perbuatannya, baik perbuatan hati maupun perbuatan fisik, baik yang berkenaan dengan itikad, etika, maupun praktis, baik yang mengatur hubungan antar individu dengan individu, dengan masyarakat, individu dengan negara, individu dengan lingkungan, maupun individu dengan Tuhannya.</p><p> </p><p> </p>
UNIVERSALISME ISLAM DAN KONTRIBUSINYA DALAM KONSTRUK INDONESIA BARU
Authors: Sumbulah Umi 
Published: June 2018

<p>New Indonesia, until this era still become an issue. Various forums of seminars and dialogues are held in order to find meaning and format forward the figure of a new Indonesia. The concept of Islamic universalism and its contribution in the New Indonesia construct can depart from the thought of the concept of al dharnriyat al khamsab, which of course includes its all-encompassing human and humanitarian history of Indonesia, which in many ways is diversity, in accordance with the concept of rahmatan Iil al alamin. Each component of the nation is required to have a prerequisite in the form of independence and democratization which includes freedom, justice and equality. Prerequisites intended, demanding implementation not only by the community but also good will and political will from the ruling elite. The actualization of the values of Islamic universalism in order to lead to New Indonesia is not just a mere academic camouflage.</p><p> </p><p>Indonesia baru, hingga detik inipun masih menjadi bahan perbincangan yang cukup menarik. Berbagai forum seminar dan dialog diselenggarakan dalam rangka mencari makna dan format ke depan sosok Indonesia baru. Konsep universalisme Islam dan konstribusinya dalam konstruk Indonesia Baru dapat berangkat dari pemikiran tentang konsep al dharnriyat al khamsab, yang tentu saja pemanahannya mencakup seluruh manusia dan perjalanan sejarah kemanusiaan Indonesia, yang dalam banyak hal bersifat diversity, sesuai dengan konsep rahmatan Iil al alamin. Setiap komponen bangsa diharuskan memiliki prasyarat berupa independensi dan demokratisasi yang meliputi freedom, justice dan equality. Prasyarat dimaksud, menuntut implementasi tidak hanya oleh masyarakat tetapi juga good will and political will dari elite penguasa. Teraktualisasikannya nilai-nilai universalisme Islam dalam rangka menuju Indonesia Baru bukan hanya kamuflase akademik belaka.</p><p> </p>
PERSPEKTIF KEBERHASILAN PENDIDIKAN TINGGI: Ikhtiar Mencari Strategi Untuk Pengembangan Pendidikan Tinggi Islam
Authors: Baharuddin Baharuddin 
Published: June 2018

<p>The selection of universities still seems to be a problematic issue. Because until now, the variables to measure whether higher education institutions, especially PTI, are successful and reliable as a vehicle and means to foster and simulate their next generation is still and will remain questionable extension. Especially when the issue of "educated unemployment" becomes the focus of more parties, doubts about the extension of college are becoming increasingly sharp. An educational institution, especially higher education, is said to be successful or does not need to be viewed from various points of view; input (students), output (achievement), organizational processes and external components (parents and community). All of these components in successful educational institutions must be able to be achieved and implemented properly and able to establish cooperation in a constructive, intense and professional. Building a successful higher education is not an easy and easy job. Continuous effort in actualizing these ideals should not stop without seeing a satisfactory success.</p><p> </p><p>Pemilihan perguruan tinggi tampaknya masih menjadi semacam persoalan yang masih sangat problematis. Karena sampai saat ini, variabel untuk mengukur apakah lembaga pendidikan tinggi, lebih-lebih PTI, itu berhasil dan bisa diandalkan sebagai wahana dan sarana untuk memupuk sekaligus mengkader generasi penerusnya masih terus dan akan tetap dipertanyakan ekstensinya. Lebih-lebih ketika isu "pengangguran terdidik" menjadi sorotan lebih banyak pihak, keraguan terhadap ekstensi perguruan tinggi menjadi semakin tajam. Suatu Iembaga pendidikan terutama pendidikan tinggi, dikatakan berhasil atau tidak perlu dilihat dari berbagai sudut pandang; input (mahasiswa), output (pencapaian), proses organisasi dan komponen ekstemal (orang tua dan masyarakat). Semua komponen ini dalam lembaga pendidikan yang berhasil harus mampu dicapai dan dilaksanakan dengan baik dan mampu menjalin kerja sama secara konstruktif, intens dan profesional. Membangun sebuah pendidikan tinggi yang berhasil, bukanlah suatu pekerjaan yang gampang dan mudah. Usaha secara kontinuitas dalam mengaktualisasikan cita-cita tersebut tidak boleh berhenti begitu saja tanpa melihat suatu keberhasilan yang memuaskan.</p><p> </p>
PERUBAHAN SOSIAL DAN PENGARUHNYA TERHADAP PERUBAHAN KURIKULUM PENDIDIKAN
Authors: Ibrahim Abd. Latif Fuad , Fannani Bakhruddin 
Published: June 2018

<p>Every society will not remain in one condition only, but undergoing continuous change in its various aspects; social, economic, and political. No single society is fixed and unchanged. Therefore, it can be said that every society is changing, and always changing. The educational curriculum must be flexible and can be improved. If there are substantial changes occurring within a society, the educational curriculum needs to be reviewed so that it can go hand in hand with the change, then its value and function can serve as a correct tool for educating the children of the community. If not, then the educational curriculum will become something foreign, which is no longer suitable for the people who have undergone a change. The educational curriculum is required to give sufficient attention to the orientation of the phenomenon, the extent of its impact and its influence on people's lives.</p><p> </p><p>Setiap masyarakat tidak akan tetap berada dalam satu kondisi saja, tetapi mengalami perubahan secara terus menerus dalam berbagai aspeknya; sosial, ekonomi, dan politik. Tidak ada satu masyarakat pun yang tetap dan tidak berubah. Oleh sebab itu, dapat dikatakan bahwa setiap masyarakat itu mengalami perubahan, dan senantiasa berubah. Kurikulum pendidikan itu harus lentur dan bisa diperbaiki. Jika ada perubahan mencasar yang terjadi di dalam suatu masyarakat, maka kurikulum pendidikannya perlu ditinjau kembali agar dapat berjalan seiring dengan perubahan tersebut, lalu nilai dan fungsinya dapat dijadikan sebagai satu perangkat yang benar untuk mendidik anak-anak masyarakat. Jika tidak, maka kurikulum pendidikan tersebut akan menjadi sesuatu yang asing, yang tidak cocok lagi untuk masyarakatnya yang telah mengalami perubahan. Kurikulum pendidikan dituntut untuk memberikan perhatian yang cukup kepada orientasi fenomena, sejauh mana dampak dan pengaruhnya dalam kehidupan masyarakat.</p><p> </p>
MENGANGANKAN HAM INDONESIA BERWAWASAN ISLAM
Authors: Zenrif M. Fauzan 
Published: June 2018

<p>Indonesian Muslims when faced with social problems, especially those related to law and justice, always involve the dualism of thought, Islam and kindonesiaan. When human rights issues arise, the unification of Indonesian Islam seeks to justify the problem into its shari'ah. This is normal, because Islam is believed not only mngatur spirituality of his people, but also related to social rules. This paper tries to explain what Muslims can do as the majority of their beloved country's people in dealing with human rights issues. Besides, the effort to enforce the law for internal Islamic and national interests. This paper also discusses how the Islamic perspective is about this. Discussing human rights issues can not be separated from how the principle as stipulated in Islam. The substance that need to be put forward is the fulfillment of the right of life security and the right of freedom to choose religion or belief. Similarly, the right of equality and justice before the law. Therefore, it is necessary to implement the strategy of human rights by considering three priorities. First, that Islamic law is universal. Secondly, Islamic law is never retroactive. Third, that Islamic law does not impose burden except on the perpetrators.</p><p> </p><p>Umat Islam Indonesia apabila dihadapkan pada permasalahan-permasalahan sosial, terutama yang berkaitan dengan hukum dan peradilan, selalu melibatkan dualisme pemikiran, keislaman dan kindonesiaan. Ketika permasalahan Hak Asasi Manusia (HAM) muncul, uniat Islam Indonesia berusaha mencarikan justifikasi permasalahan tersebut ke dalam syari’atnya. Hal ini wajar-wajar saja, sebab Islam diyakini tidak sekedar mngatur spiritualitas umatnya, tetapi juga menyangkut aturan-aturan sosial. Tulisan ini mencoba menjelaskan apa yang bisa diperbuat umat Islam sebagai mayoritas masyarakat negerinya tercinta dalam menghadapi permasalahan hak asasi manusia. Selain itu dibahas upaya menegakkan hukum untuk kepentingan internal Islam dan nasional. Tulisan ini juga membahas bagaimana perspektif Islam mengenai hal ini. Membahas permasalahan HAM tidak lepas dari bagaimana prinsipnya sebagaimana diatur dalam Islam. Secara substansif yang perlu dikedepankan yaitu pemenuhan hak keamanan jiwa dan hak kebebasan memilih agama atau keyakinan. Demikian pula hak kesamaan dan keadilan di depan hukum. Untuk itu diperlukan strategi implementasi hak asasi manusia dengan mempertimbangkan tiga prioritas. Pertama, bahwa hukum Islam bersifat universal. Kedua, bahwa hukum Islam tidak pernah berlaku surut. Ketiga, bahwa hukum Islam tidak memberikan beban kecuali pada pelakunya.</p>
KEKERASAN DAN KEKUASAAN DALAM PRAKSIS BERBAHASA: Memahami Kekerasan dalam Perspektif Galtung
Authors: Rahardjo Mudjia 
Published: June 2018

<p>As a social phenomenon, violence has attracted the interest of social scientists to further study, cultivate and explore its exploratory theorists. One of them is Johan Galtung. This paper explores Galtung's theory of violence in relation to language practice. According to Johan Galtung, violence occurs when humans are affected in such a way that actual physical and mental realizations are under their potential realization. Galtung will see something as violent if in the future the event can be overcome or prevented, but still left. As a symbolic reality, language can not be separated from the inner world of the wearer and the social setting that exists. These include social conflicts such as violence, murder, rape, looting, harassment, robbery, repression, and so on. Coinciding with the violent phenomenon that plagues this nation, modesty or ethical language is now experiencing erosion or extraordinary setbacks. To overcome this, ethics of language decency needs to be addressed in the context of language teaching in Indonesian cultural lands.</p><p> </p><p>Sebagai fenomena sosial, kekerasan telah menarik minat para ilmuwan sosial untuk lebih jauh mempelajari, menggeluti dan mencari teoretis eksplanatorisnya. Salah satu di antaranya ialah Johan Galtung. Tulisan ini memaparan tentang teori kekerasan Galtung dalam hubunganya dengan praktik bahasa. Menurut Johan Galtung, kekerasan terjadi bila manusia dipengaruhi sedemikian rupa sehingga realisasi jasmani dan mental aktualnya berada di bawah realisasi potensialnya. Galtung akan melihat sesuatu sebagai kekerasan bila di masa mendatang peristiwa tersebut bisa diatasi atau dicegah, tetapi tetap dibiarkan. Sebagai realitas simbolik, bahasa tidak bisa lepas dari dunia batin pemakainya dan setting sosial yang ada. Termasuk di antaranya konflik-konflik sosial berupa kekerasan, pembunuhan, pemerkosaan, penjarahan, pelecehan, perampokan, penindasan, dan lain sebagainya. Berbarengan dengan fenomena kekerasan yang melanda bangsa ini, kesopanan atau etika berbahasa kini mengalami erosi atau kemunduran luar biasa. Untuk mengatasi itu, etika kesopanan berbahasa perlu disikapi dalam konteks pengajaran bahasa dalam lahan budaya Indonesia. </p><p> </p><p> </p>
ORIENTASI PENDIDIKAN BERWAWASAN KEBANGSAAN
Authors: Hasyim Farid 
Published: June 2018

<p>Restoration and educational reform can be a moment of self-awareness as a nation of justice and equality issues. Sensitivity to economic and social inequalities should grow in the awareness of society, more so with an increasingly erratic atmosphere, and this moment will be useless if education is not directed to openness, critical nature and respect for the diversity of political, economic, social and culture of the true nation that is in accordance with the 1945 Constitution and the philosophy of the state and nation of Indonesia.</p><p> </p><p>Restorasi dan reformasi pendidikan bisa menjadi momen penyadaran diri sebagai bangsa akan masalah keadilan dan kesetaraan. Kepekaan terhadap kesenjangan ekonomi dan sosial seharusnya semakin tumbuh dalam kesadaran masyarakat , lebih-lebih dengan adanya suasana yang semakin tidak menentu, dan momen ini akan sia-sia bila pendidikan tidak diarahkan kepada keterbukaan, sifat kritis serta menghormati keanekaragaman struktur politik, ekonomi, sosial dan budaya bangsa yang benar yang sesuai dengan UUD 45 dan falsafah negara dan bangsa Indonesia.</p>