bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐Coordination Crystallographic Lattice Engineering to Discover Ce3+‐Activated Ultra‐Wide Visible‐to‐Near‐Infrared Luminescent Materials
Authors: Zhang Min , Dang Peipei , Zeng Zixun , Liu Dongjie , Wan Yujia , Wei Yi , Lian Hongzhou , Li Guogang , Lin Jun 
Published: November 2024

AbstractDevelopment of ultra‐broadband visible‐to‐near‐infrared (VIS‐NIR) luminescent materials is a challenging but rewarding endeavor, as they are highly desirable for a number of applications in photonics, optoelectronics, and biological sciences. Nevertheless, to date, rare earth‐doped phosphors that can be efficiently excited by blue light and produce broadband emission in the VIS‐NIR regions remain scarce. In this study, a series of Ce3+‐doped Ba3M4O9 (M = Sc, Lu, Y) broadband luminescent materials are designed based on low‐coordination crystallographic lattice engineering. Among these materials, Ba3Y4O9:Ce3+ produces a continuous ultra‐wide VIS‐NIR emission (λem = 660 nm) in the range of 500–950 nm under 410 nm light excitation. This emission wavelength is the longest among those observed in Ce3⁺‐doped oxide materials. Structural refinement, theoretical calculation, and spectral analysis demonstrate that this VIS‐NIR broadband emission is attributed to the occupying multiple distorted octahedral lattice sites by Ce3+ in Ba3Y4O9. Several strategies are employed to enhance the luminescence intensity and thermal stability of this material, including the use of carbon paper coating, the incorporation of co‐solvents, and the addition of GeO₂ or ZrO₂. Furthermore, the as‐prepared materials demonstrate multifunctional applications in white light‐emitting diodes (WLED), night vision, and fluorescent thermometers. This study offers insights into the design of Ce3+‐doped ultra‐wide VIS‐NIR light‐emitting materials.
Ultra‐Low Power Photosynaptic Devices Based on Persistent Photoconductivity‐Modulated SnO2
Authors: Lee Woo‐Jin , Sohn Sang‐Hyun , Park Il‐Kyu 
Published: November 2024

AbstractRealizing visual perception performance using robust metal oxide devices is highly desirable for brain‐inspired neuromorphic computing, visual prosthetics, and artificial intelligence. SnO2, a representative transparent semiconductor, has attracted considerable attention for its potential in ultraviolet photodetectors and photosynaptic devices operating in solar‐blind spectral ranges. This problem has been circumvented by lowering the electron concentration and reducing the persistent photoconductivity (PPC), one of the essential properties of photosynaptic devices. In this case, the electron concentration and PPC properties in SnO2 must be controlled independently. This paper reports the successful control of PPC in SnO2 by controllable addition of Zn and Sr ions, which act as acceptors to annihilate the charge carriers and as a reductant to form oxygen vacancies, respectively. Zn and Sr‐added SnO2 exhibits superior synaptic performance with low energy consumption, successfully imitating the biological synapses without a gate electrode. As a result, the PPC remains at about 40% even after 20 seconds of turning off the ultraviolet light, and energy consumption is reduced to 1–10 fJ, similar to energy consumption with biological synapses. A novel optical sensor that can receive analog signals is demonstrated using a photosynaptic device with Zn and Sr‐added SnO2 thin films.
Advancements in Cancer Research: 3D Models, Single‐Cell, and Live‐Cell Techniques for Better Insights
Authors: Carnevali Federica , Forciniti Stefania , Onesto Valentina , Siciliano Anna Chiara , Iuele Helena , Grasso Giuliana , da Cruz Anderson Fraga , Serra Ilaria , Depalma Norma , D'Ugo Stefano , Piscitelli Prisco , Spampinato Marcello G. , Gigli Giuseppe , Camargo de Oliveira Carolina , del Mercato Loretta L. 
Published: November 2024

AbstractThe present review provides a comprehensive overview of the current state of in vitro cancer studies, focusing on recent advancements and ongoing in cell culture models and analyses techniques. Cancer cells grow in a complex and dynamic environment, interacting with various cellular components, such as stromal cells, cancer‐associated fibroblasts, immune cells, and the extracellular matrix (ECM). The ECM provides structural support and unique characteristics essential for tumorigenesis. Accurately modeling this intricate tumor microenvironment and precisely analyzing cell–cell and cell–ECM interactions are crucial for understanding cancer progression and therapeutic responses. Consequently, oncology research is advancing toward a) three‐dimensional tumor models, b) single‐cell level analyses, and c) live‐cell analyses. This review aims to elucidate current knowledge in this field, emphasizing the benefits these innovative approaches offer over traditional two‐dimensional models, bulk analyses, and endpoint measurements.
pH‐Dependent Assembly and Stability of Toll‐Like Receptor 3/dsRNA Signaling Complex: Insights from Constant pH Molecular Dynamics and Metadynamics Simulations
Authors: Li Penghui , Shi Mingsong , Wang Yibo , Liu Qiong , Du Xiubo , Wang Xiaohui 
Published: November 2024

AbstractThe pH‐dependent assembly of Toll‐like receptors (TLRs), which triggers a threshold‐like response, is a key principle in immune signaling. While crystallography has revealed the intricate structure of these assembly complexes, the mechanisms underlying their pH dependency remain unclear. Herein, constant pH simulations and metadynamics are employed to investigate the pH‐dependent assembly and stability of the TLR3/dsRNA signaling complex. The findings demonstrate that system pH regulates complex assembly and stability by modulating the protonation and charge states of histidines. Histidines in TLR3 act as pH‐dependent, positively charged binding sites that capture negatively charged dsRNA. Additionally, these histidines form a [H682⁺]—[E626⁻] dipole, facilitating the assembly of two TLR3 molecules into an antisymmetric dimer through dipole–dipole interactions. Surprisingly, TLR3 can shift the pKa values of key histidines from their model pKa of 6.5, increasing protonation likelihood and enhancing ligand binding. Notably, the aromatic residue Phe84, located within the dsRNA binding site [His39⁺–His60⁺–Phe84–His108⁺], alters the pKa of His60 through cation‐π interactions with its protonated state. This study offers new insights into the molecular mechanisms underlying pH‐dependent immune signaling via higher‐order assemblies and suggests potential applications for histidine in self‐assembling biomaterials.
The Impact of Non‐Monolithic Semiconductor Capacitance on Organic Electrochemical Transistors Performance and Design
Authors: Dreamer Ned E. , Koutsouras Dimitrios A. , Hassanpour Amiri Morteza , Gkoupidenis Paschalis , Asadi Kamal 
Published: November 2024

AbstractThe existing device models for organic electrochemical transistors (OECTs) fail to provide any device design guidelines for optimized performance parameters such as transconductance that are pivotal for the applications OECTs in sensing. Moreover, the current models are based on the questionable assumption of a homogenous organic semiconductor layer, and all predict a linear behavior of the resistance with the OECT channel length. Consequently, the experimentally observed nonlinear resistance behavior in OECTs has been overlooked thus far. Here, an OECT device model is developed that accurately describes the nonlinear behavior of the OECT channel resistance and offers the first guidelines for maximizing transconductance. The model is inherently nonlinear and the nonlinearity stem from the non‐monolithic capacitance of the organic semiconductor layer. Moreover, the model provides a consistent and reliable estimations for the contact resistance in OECTs. The success of the model in accurately describing and providing predictions of the OECT operation by relating the device's geometrical parameters with electrochemical parameters of the semiconductor layer paves the way toward unlocking OECT potentials in diverse applications, from biosensing to neuromorphic computing and flexible electronics.
Highly Reversible Sodium Metal Batteries Enabled by Extraordinary Alloying Reaction of Single‐Atom Antimony
Authors: Zhao Si , Chen Xudong , Wang Yan , Hong Zhensheng , Zheng Lituo , Zhang Yan , Wei Mingdeng , Lu Jun 
Published: November 2024

AbstractThe unique coordination configuration of single‐atom materials (SAMs) allows precise reaction control at atomic‐level and a potential of unusual electrochemical reaction. Nevertheless, it is a big challenge to prepare main group element with high loading content. Here, multifield‐regulated synthesis (MRS) technology is utilized to rapidly produce single‐atom antimony (Sb) metal with a high loading of 15 wt.%. Ab initio molecular dynamics simulations reveal the significantly enhanced reaction kinetics of Sb and nitrogen‐doped graphene by multi‐physics field coupling. Compared with common metallic Sb nanoparticles, atomically dispersed Sb displays remarkably improved electrochemical reaction kinetics and stable structure due to the negligible variation of stresses and volume expansion during the pseudocapacitive alloying‐dealloying process. Such extraordinary alloying reaction in well‐dispersed Sb atoms enabling homogeneous ion flow can serve as active nucleation sites for regulating even Na metal nucleation and growth. As a result, copper foil coated with only ≈3 µm thickness of such material exhibits a high Coulombic efficiency of up to 99.99%, an ultra‐low overpotential of 3 mV, and a long lifetime exceeding 2500 h in symmetrical cells. Furthermore, an anode‐free MRS‐SbSA||Na3V2(PO4)3 battery is constructed, which demonstrates exceptionally high energy density (≈362 Wh Kg−1), outstanding rate capability and good cycling stability.
Modulating Local Oxygen Coordination to Achieve Highly Reversible Anionic Redox and Negligible Voltage Decay in O2‐Type Layered Cathodes for Li‐Ion Batteries
Authors: Yang Xiaoxia , Wang Kai , Zhang Jilu , Li Hang , Liu Hao , Zhao Tian , Zhai Xinyue , Wang Qin , Fan Chengjun , Etter Martin , Indris Sylvio , Hua Weibo , Ouyang Xiaoping 
Published: November 2024

AbstractO2‐type layered oxides have emerged as promising cathode materials for high‐energy lithium‐ion batteries, offering a solution to mitigate voltage decay through reversible transition metal (TM) migration between TM and Li layers during cycling. However, achieving a fully reversible oxygen redox remains a significant challenge. Here, this is addressed by introducing Li─O─Li configurations in the layered structure of Li0.85□0.15[Li0.08□0.04Ni0.22Mn0.66]O2 (O2‐LLNMO), where □ represents vacancies. This adjustment alters the redox‐active oxygen environment and increases the energy gap between the O 2p nonbonding and TM─O antibonding bands. As a result, the contribution of lattice oxygen to capacity is significantly enhanced, improving the reversibility of oxygen redox processes. The O2‐LLNMO cathode demonstrates minimal voltage decay (0.13 mV per cycle) and excellent cycling stability, retaining 95.8% of its capacity after 100 cycles. A novel strategy is presented to design high‐performance layered oxides with stable anionic redox activity, advancing the development of next‐generation lithium‐ion batteries.
Bipolar Membranes With Controlled, Microscale 3D Junctions Enhance the Rates of Water Dissociation and Formation
Authors: Gao Tianyue , Schulte Leanna , Xiao Langqiu , Yamamoto Eisuke , Metlay Amy S. , Sheehan Colton J. , Marth Sariah , Park Heemin , Sasmal Sayantan , Galang Francisco J. , Bae Chulsung , Weber Adam Z. , Boettcher Shannon W. , Mallouk Thomas E. 
Published: November 2024

AbstractA soft lithographic method is developed for making bipolar membranes (BPMs) with catalytic junctions formed from arrays of vertically oriented microscale cylinders. The membranes are cast from reusable polydimethylsiloxane (PDMS) molds made from silicon masters, which are fabricated on 2″ to 4″ wafer scales by nanosphere lithography. High‐aspect‐ratio junctions are made on a length scale similar to the thickness of optimized catalyst layers for water dissociation, creating a platform for probing the dual effects of catalysis and local electric field at the microscale BPM junction. Optimized polymer materials and nanoscale metal oxide catalysts are used in this study. 3D BPMs are tested under reverse and forward bias conditions, exhibiting superior performance relative to their 2D counterparts. Under forward bias in H2‐O2 fuel cells, 3D BPMs achieve a current density of 1500 mA cm−2, ≈7 times higher than 2D membranes made from the same materials.
Combing mobile electrical capacitance tomography with Fourier neural operator for 3D fluidized beds measurement
Authors: Zhang Cheng , Li Anqi , Li Chenggong , Li Xue , Ye Mao , Liu Zhongmin 
Published: November 2024

AbstractDespite the practical importance, 3D measurements of gas–solid distribution in fluidized beds calls for further breakthroughs. Here an approach combing a recently developed mobile electrical capacitance tomography (ECT) sensor with Fourier Neural Operator (FNO) is developed, in which the fluidized bed is divided into a series of cross‐sectional slices along axial direction. At any given instant, the gas–solid distribution in one slice is measured by mobile ECT and the others, meantime, are predicted by FNO pre‐trained using experimental data. We verified this approach via computational fluid dynamics (CFD) simulations and experimental measurement of static object (i.e., cone, cylinder, and sphere) in fluidized bed. Following we applied this approach to direct measure 3D gas–solid distribution in a bubbling fluidized bed, and found that satisfactory image correlation coefficients and solid concentration average absolute deviation could be obtained, which indicates the proposed approach is promising for 3D fluidized bed measurements.
A second RUBCN variant associated with epileptic encephalopathy and neurodevelopmental delay
Authors: Magalie Lodin‐Pasquier , Yline Capri , Olivier Patat , Blandine Dozières‐Puyravel , Nathalie Couque 
Published: November 2024

ABSTRACTThe RUBCN gene encodes a widely expressed protein called Rubicon, the main function of which is to negatively regulate macroautophagy. A single homozygous pathogenic variant of the RUBCN gene has been reported to date in two unrelated consanguineous Saudi families with spinocerebellar ataxia autosomal recessive 15 (OMIM#613516). This variant is responsible for the deletion of the highly conserved Rubicon Homology (RH) domain, which is important for the colocalization of Rubicon with Rab7 in the late endosome. In this work, we describe a female patient with childhood‐onset epileptic encephalopathy and neurodevelopmental delay carrying a novel homozygous variant in RUBCN (NM_014687.3: c.2126 + 1G>A). A functional study of the RNA revealed that this variant completely abolishes the consensus donor site at the exon 14/intron 14 junction, resulting in the absence of expression of the reference transcript. Two alternative transcripts were expressed: a major transcript resulting from activation of an alternative exonic splice site and a minor transcript with skipping of exon 14. The two alternative transcripts lead to a shift in the reading frame introducing a premature stop codon. The resulting truncated protein lacks the RH domain, which may lead to defective endosomal trafficking as previously described. To our best knowledge, this is the first report of an impairment of RUBCN caused by a splice variant.
Design for a Solid‐State Luminescent Sensor Through Photo‐Induced Electron Transfer Based on Pyrene‐Modified o‐Carborane
Authors: Nishiyama Shunsuke , Ochi Junki , Tanaka Kazuo 
Published: November 2024

AbstractAryl‐tethered o‐carboranes have attracted attention as a platform for obtaining functional solid‐state luminescent materials with stimuli‐responsiveness. To extend the versatility and applicability for advanced sensing technologies, it is essential to establish new mechanisms for regulating solid‐state luminescent properties. In this study, we demonstrate the regulation of solid‐state luminescent properties of the modified o‐carborane through photo‐induced electron transfer. We synthesized the triad based on o‐carborane modified with pyrene as a luminophore from intermolecular charge transfer and diethylaniline as a quencher. In the pristine solid state, significant emission was hardly observed due to emission quenching through photo‐induced electron transfer, while intense emission was recovered by acid vapor fuming for protonation at the diethylaniline moiety. Moreover, we confirmed that reversible changes underwent by amine vapor fuming. These results mean that solid‐state luminescent properties of o‐carborane can be controlled by the commodity photochemical process according to the molecular design.
The relationship between cause of death and skeletal markers of physiological stress in the Hamann‐Todd collection
Authors: Simon Allyson M. , Mellendorf Tempest D. , Cheverko Colleen M. , Clark Melissa A. , Hubbe Mark 
Published: November 2024

AbstractObjectivesSocioeconomic status, past stress events, and other factors may contribute to the cumulative burden of physiological stress, which influences an individual's susceptibility to mortality and cause of death (COD). Here, we explore the association between skeletal evidence of stress and COD in the Hamann‐Todd Osteological Collection (HTOC), a predominantly low socioeconomic status sample from the late 19th and early 20th century.Materials and MethodsSkeletal markers of stress including linear enamel hypoplasia (LEH), stature, and antemortem tooth loss (AMTL) were analyzed in 298 individuals in the HTOC. Recorded CODs were grouped into six broad categories and contrasted with stress indicators, ages‐at‐death, and demographic variables, using various parametric and non‐parametric statistical tests.ResultsCOD varied by socially ascribed race and sex within the sample. Overall, infectious diseases were more prevalent than degenerative diseases. Individuals that died of infectious diseases had significantly lower ages‐at‐death compared to degenerative diseases (p < 0.001). There was no association between LEH and COD (χ2 = 4.449, p = 0.487). Stature varied significantly across COD categories for males (F = 2.534, p = 0.032), but not females (F = 1.733, p = 0.132). Controlling for age‐at‐death, AMTL prevalence was associated with COD (H = 18.53, p = 0.002), with cardiovascular disease being associated with higher prevalence of AMTL.DiscussionThese findings show that some skeletal stress indicators are associated with COD in the HTOC, but the causal pathways of these relationships are not clear. This study adds to growing bodies of literature exploring relationships between past stress events and susceptibility to mortality and long‐term consequences of poor living conditions for past individuals.
Versatile Mechanochemical Reactions Via Tailored Force Transmission in Mechanophores
Authors: Xu Deao , Liu Wenjie , Tian Shijia , Qian Hai 
Published: November 2024

AbstractIn polymer mechanochemistry, regulating the intrinsic mechanical reactivity of a mechanophore offers extensive opportunities in material science, enabling the development of hierarchical and multifunctional polymer‐based materials. Recent advances have focused on innovating various types of mechanophores with inherent reactivity (e.g. regioselectivity and stereoselectivity). However, little attention has been given to modulating their reactivity by tailoring force transmission within mechanophores. Here, we introduce a novel approach through the implementation of a cyclic pulling geometry into an anthracene‐maleimide (AM) mechanophore. This approach manipulates force transmission within the mechanophore and effectively regulates its reactivity from 0.0160 min−1 to 0.00133 min−1, achieving up to a 12‐fold change. Mechanochemical coupling analysis indicates that the split force transmission along ring chains contributes to the significant difference in mechanochemical reactivity. By leveraging the distinct force transmission pathways within cyclic and linear AM mechanophores, we covalently integrate them with a spiropyran mechanophore to design tandem mechanophore systems for hierarchical mechanochemical activation. These findings highlight the efficacy and versatility of the cyclic pulling strategy in modulating mechanophore reactivity, providing valuable insights for the design of tunable multifunctional polymer‐based materials.
Enhancing the Efficiency and Stability of Inverted Perovskite Solar Cells and Modules through Top Interface Modification with N‐type Semiconductors
Authors: Liu Qiuju , Ding Lei , Fu Jianfei , Zheng Bolin , Yu Dongsheng , Bai Hua , Tian Qingyong , Fan Bin , Liu Yanfeng , Pang Shuping , Liu Yang 
Published: November 2024

AbstractThe interface modification between perovskite and electron transport layer (ETL) plays a crucial role in achieving high performance inverted perovskite photovoltaics (i‐PPVs). Herein, non‐fullerene acceptors (NFAs), known as Y6‐BO and Y7‐BO, were utilized to modify the perovskite/ETL interface in i‐PPVs. Non‐polar solvent‐soluble NFAs can effectively passivate surface defects without structural damage of the underlying perovskite films. Additionally, the improved phenyl‐C61‐butyric acid methyl ester (PCBM) ETL induced by NFAs modification significantly accelerates the electrons extraction. As a result, both Y6‐BO and Y7‐BO exhibit more effective interface modification effects compared to traditional PI molecules. The power conversion efficiency (PCE) of the inverted perovskite solar cell (i‐PSC) modified with Y7‐BO reaches 25.82 %. Moreover, the adoption of non‐polar solvents and the superior semiconductor properties of Y7‐BO molecules also enable perovskite solar modules (i‐PSM) with effective areas of 50 cm2, 400 cm2, and 1160 cm2 to achieve record efficiencies of 23.05 %, 22.32 %, and 21.1 % (certified PCE), respectively, making them the best PCE reported in the literature. Importantly, enhanced interface mechanical strength between the perovskite and PCBM layer results in significantly improved environmental and operational stability of the cells. The cells modified with Y7‐BO maintained 94.4 % of the initial efficiency after 1522 hours of maximum power point aging.