bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bienen- und Wespengiftallergie in verschiedenen Lebensphasen
Authors: Stoevesandt J. , Trautmann A. 
Published: February 2019

ZusammenfassungDas individuelle Risiko für anaphylaktische Stichreaktionen bleibt im Laufe eines Menschenlebens nicht konstant, sondern ist von Lebensalter und Gesundheitszustand, von persönlichen Aktivitäten und Vorlieben abhängig. Lebensumstände und Begleiterkrankungen können darüber hinaus auch Entscheidungen hinsichtlich Diagnostik und Therapie beeinflussen. In der vorliegenden Arbeit werden Risiken und Besonderheiten von Patienten mit Bienen-/Wespengiftallergie in verschiedenen Lebensphasen erörtert. Schwere anaphylaktische Stichreaktionen sind im Kindes- und Jugendalter trotz verhältnismäßig häufiger Stiche durch Bienen und Wespen selten. Allergische Nebenwirkungen einer Immuntherapie mit Bienen-/Wespengift hingegen sind ebenso häufig wie bei Erwachsenen, aber i. d. R. sehr gut beherrschbar. Schwangeren unter bereits laufender Immuntherapie mit Bienen-/Wespengift sollte bei guter Verträglichkeit eine Therapiefortsetzung angeraten werden, da das Risiko von anaphylaktischen Therapiezwischenfällen als geringer eingeschätzt wird als die Gefahr einer schweren Stichreaktion im Falle eines vorzeitigen Abbruches. Die Wahrscheinlichkeit von Bienen oder Wespen gestochen zu werden und damit auch das Risiko anaphylaktischer Stichreaktionen werden durch Freizeitverhalten und Berufswahl entscheidend mitbestimmt. Das Risiko schwerer und möglicherweise tödlicher Stichreaktionen ist bei Patienten mit indolenter systemischer Mastozytose erheblich erhöht, steigt aber auch mit dem Lebensalter und möglicherweise im Rahmen bestimmter kardiovaskulärer Erkrankungen. Die Sicherheit einer Immuntherapie mit Bienen-/Wespengift wird durch antihypertensiv wirkende Medikamente, insbesondere auch durch β-Blocker und ACE-Hemmer, nicht beeinflusst. Bedenken bezüglich Sicherheit und Effektivität der Immuntherapie bei gleichzeitig bestehenden Autoimmun- oder Tumorerkrankungen konnten bislang nicht durch klinische Daten begründet werden. Eine Immuntherapie mit Bienen-/Wespengift kann auch bei Tumorerkrankungen in stabiler Remission oder behandelten Autoimmunerkrankungen durchaus sinnvoll sein.
Perforation als Spätkomplikation nach endoskopischer Vollwandresektion eines Rezidivadenoms im Colon sigmoideum
Authors: Hürtgen Susanne , Schmitz Georg , Junge Karsten , Breuer Elisabeth , Tischendorf Jens 
Published: February 2019

ZusammenfassungDie endoskopische Vollwandresektion findet ihre Anwendung unter anderem bei kolorektalen Polypen, die aufgrund von Vernarbungen ein negatives Lifting aufweisen und sich deshalb mittels konventioneller endoskopischer Mukosaresektion nicht abtragen lassen. Die endoskopische Vollwandresektion kann dabei mithilfe spezieller Instrumente, wie dem full-thickness resection device (FTRD®), risikoarm in einem Funktionsschritt ausgeführt werden. Die in der Literatur beschriebenen Hauptrisiken sind Blutungen sowie Perforationen. Bei den bisher beschriebenen Perforationen konnten vorangegangene Gerätedefekte oder patientenbezogene prädisponierende Faktoren für eine Perforation nachgewiesen werden.Wir berichten über eine 55-jährige Patientin, welche aufgrund eines Rezidivadenoms im Colon sigmoideum mit fokal hochgradiger intra-epithelialer Neoplasie einer endoskopischen Vollwandresektion mittels FTRD® unterzogen wurde. Nach primär komplikationslosem Verlauf zeigte sich sieben Tage nach der Intervention eine sekundäre Perforation mit Ausbildung einer eitrigen Peritonitis, sodass eine Sigmaresektion notwendig wurde. Hinweise auf einen Gerätedefekt lagen nicht vor, ebenso ergaben sich keine prädisponierenden patientenbezogenen Faktoren, welche das Auftreten einer Perforation begünstigen.Unser Fallbericht demonstriert somit die Notwendigkeit einer weiteren klinischen Nachbeobachtung auch nach zunächst unauffälligem Verlauf einer endoskopischen Vollwandresektion, da Spätperforationen als Komplikation auftreten können.
Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice
Authors: Manda Vamshi , Haron Mona , Mir Tahir , Avula Bharathi , Ashfaq Mohammad , Haider Saqlain , Chittiboyina Amar , Khan Ikhlas , Khan Shabana 
Published: February 2019

AbstractAegeline is claimed to be a biologically active constituent of Aegle marmelos. Preclinical studies have reported possible therapeutic potential for aegeline against obesity and diabetes. In recent years, aegeline has been added to several weight loss products. However, the consumption of aegeline-containing supplements such as OxyELITE Pro and VERSA-1 has been linked to multiple cases of acute and chronic liver failure. This study was carried out to evaluate the pharmacokinetics and tissue distribution of aegeline in ND4 mice. Two doses of aegeline, a human equivalent dose (1×) 30 mg/kg and a 10× dose (300 mg/kg), were orally administered to the mice, and blood and tissue samples were collected over 8 h. The quantitative analysis of plasma and tissue homogenates (liver, kidney, and brain) was done by UHPLC-QTOF to determine aegeline concentrations. The peak plasma level of aegeline was achieved at a Tmax of 0.5 h, indicating its rapid absorption from the gastrointestinal tract. Aegeline was not detected in the plasma at 8 h after oral administration, with a half-life of 1.4 ± 0.01 and 1.3 ± 0.07 h for the 30 and 300 mg/kg doses, respectively. The half-life of aegeline in the liver was 1.2 h and 1.7 h for 30 and 300 mg/kg doses, respectively, with a Tmax of 1.9 h, which indicates relatively fast elimination of aegeline from the liver.
Oral Opioid Use during Vaginal Delivery Hospitalizations
Authors: Mourad Mirella , Landau Ruth , Wright Jason D. , Siddiq Zainab , Duffy Cassandra R. , Kern-Goldberger Adina R. , D'Alton Mary E. , Friedman Alexander M. 
Published: February 2019

Objective This study aimed to determine the receipt of short-acting opioid medications during vaginal delivery hospitalizations.
Study Design The Perspective database was analyzed to evaluate patterns of short-acting oral opioid use during vaginal delivery hospitalizations from January 2006 to March 2015. Unadjusted and adjusted models evaluating the role of demographic and hospital factors were created evaluating use of opioids. Hospital-level rates of opioid use were evaluated. Opioid receipt among women with opioid abuse or dependence was evaluated based on overall hospital rates of opioid use.
Results Of 3,785,396 vaginal delivery hospitalizations from 2006 to 2015, 1,720,899 (45.5%) women received an oral opioid for pain relief. Opioid use varied significantly among the 458 hospitals included in the analysis, with one-third of hospitals providing opioids to <38% of patients, one-third to 38 to <59% of patients, and one-third to ≥59% of patients. When hospitals were stratified by overall opioid administration rates, women with opioid abuse or dependence were less likely to be given opioids in hospitals with low overall opioid rates.
Discussion The use of opioid pain medications during vaginal delivery hospitalizations varied significantly among hospitals, suggesting that standardization of pain management practices could reduce opioid use.
Cultural evolution of music
Authors: Savage Patrick E. 
Published: February 2019

AbstractThe concept of cultural evolution was fundamental to the foundation of academic musicology and the subfield of comparative musicology, but largely disappeared from discussion after World War II despite a recent resurgence of interest in cultural evolution in other fields. I draw on recent advances in the scientific understanding of cultural evolution to clarify persistent misconceptions about the roles of genes and progress in musical evolution, and review literature relevant to musical evolution ranging from macroevolution of global song-style to microevolution of tune families. I also address criticisms regarding issues of musical agency, meaning, and reductionism, and highlight potential applications including music education and copyright. While cultural evolution will never explain all aspects of music, it offers a useful theoretical framework for understanding diversity and change in the world’s music.
Radiocarbon dates and Bayesian modeling support maritime diffusion model for megaliths in Europe
Authors: Schulz Paulsson B. 
Published: February 2019

Significance
For thousands of years, prehistoric societies built monumental grave architecture and erected standing stones in the coastal regions of Europe (4500–2500 calibrated years BC). Our understanding of the rise of these megalithic societies is contentious and patchy; the origin for the emergence of megalithic architecture in various regions has been controversial and debated for over 100 y. The result presented here, based on analyses of 2,410 radiocarbon dates and highly precise chronologies for megalithic sites and related contexts, suggests maritime mobility and intercultural exchange. We argue for the transfer of the megalithic concept over sea routes emanating from northwest France, and for advanced maritime technology and seafaring in the megalithic Age.
Differences in the metabolite composition and mechanical properties of extracellular vesicles secreted by hepatic cellular models
Authors: Royo Felix , Gil‐Carton David , Gonzalez Esperanza , Mleczko Justyna , Palomo Laura , Perez‐Cormenzana Miriam , Mayo Rebeca , Alonso Cristina , Falcon‐Perez Juan M. 
Published: February 2019

ABSTRACTLiver constitutes the major metabolic factory in the organism and is involved in the synthesis, secretion and clearance of many blood‐circulating molecules. Previously, we have characterised the protein and RNA cargo of extracellular vesicles (EVs) secreted by two hepatic cellular models, a mouse hepatocyte progenitor cell line (MLP29) and primary rat hepatocytes (RHs). Here, we report the metabolome profile of these vesicles by performing a targeted UHPLC‐MS metabolomics analysis of these two cellular models and their respective secreted EVs. Visual inspection of the data through principal component analysis allows clear separation of the metabolic profile of cells and EVs, and also of both cellular models. Correlation matrix supported that lipid composition of EVs is mainly determined by parent cell composition. EVs derived from MLP29 and RHs showed a negative correlation in their percentage composition of ceramides, glycerophospholipids, sphingomyelins and triglycerides. Metabolites enriched in EVs were also different depending on the cellular model. EVs secreted by MLP29 were enriched in different species of sphingomyelins and ceramides underrepresented in EVs secreted by RHs. Remarkably, triglycerides constitute an important percentage of the composition of EVs derived from RHs. We further investigate if the differences in lipid composition were also accompanied by differences in mechanical behaviour, by using atomic force microscopy complemented with nanoindentation‐based methodology. To compare the stiffness and brittleness of EVs derived from MLP29 cell line and RH primary cells, FZ curves were performed in the centre of single vesicles and the differences found in their force‐vs.‐indentation curves suggest that RHs EVs are softer (less stiff) and less resistance to mechanical failure than MLP29 EVs. Therefore, we can conclude that EVs from different origin carry a characteristic lipid composition related to their parental cell composition, and exhibit different mechanical properties.Abbreviations: For the identification of the different species of lipids, the following abbreviations has been employed: Cer, ceramide; ChoE, Cholesteryl Ester; CMH, monohexosylceramide; DAG, diglycerid; LPC, lysophosphatidylcholin; LPI, lysophosphatidyinositol; PC, phosphocoline; PE, phoethanolamine; PI, phosphoinositol; SM, sphingomyelin; TAG, triglycerid
Optimizing of Raman gain and bandwidth for dual pump fiber optical parametric amplifiers based on four-wave mixing
Authors: Elkhashab Hatem , Mustafa Fathy , Barakat Tamer 
Published: February 2019

Abstract
This article has been retracted by IOP Publishing Limited as it contains substantial overlap with the following article published in Journal of Telecommunications System & Management: El-khashab et al 2018 J. Telecommun. Syst. Manage.
7 1. As a member of the Committee for Publication Ethics (COPE), IOP Publishing Limited has investigated this in accordance with COPE guidelines and it was agreed the article should be retracted. IOP Publishing Limited have been unable to contact the authors regarding this retraction, despite numerous attempts. The authors are encouraged to contact IOP Publishing Limited if they wish to contest this retraction.
The New Frontier: A Review of Augmented Reality and Virtual Reality in Plastic Surgery
Authors: Sayadi Lohrasb R , Naides Alexandra , Eng Maddie , Fijany Arman , Chopan Mustafa , Sayadi Jamasb J , Shaterian Ashkaun , Banyard Derek A , Evans Gregory R D , Vyas Raj , Widgerow Alan D 
Published: February 2019

Abstract
Mixed reality, a blending of the physical and digital worlds, can enhance the surgical experience, leading to greater precision, efficiency, and improved outcomes. Various studies across different disciplines have reported encouraging results using mixed reality technologies, such as augmented and virtual reality. To provide a better understanding of the applications and limitations of this technology in plastic surgery, we performed a systematic review of the literature in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The initial query of the National Center for Biotechnology Information database yielded 2544 results, and only 46 articles met our inclusion criteria. The majority of studies were in the field of craniofacial surgery, and uses of mixed reality included preoperative planning, intraoperative guides, and education of surgical trainees. A deeper understanding of mixed reality technologies may promote its integration and also help inspire new and creative applications in healthcare.
mCSEA: detecting subtle differentially methylated regions
Authors: Martorell-Marugán Jordi , González-Rumayor Víctor , Carmona-Sáez Pedro 
Published: February 2019

Abstract

Motivation
The identification of differentially methylated regions (DMRs) among phenotypes is one of the main goals of epigenetic analysis. Although there are several methods developed to detect DMRs, most of them are focused on detecting relatively large differences in methylation levels and fail to detect moderate, but consistent, methylation changes that might be associated to complex disorders.

Results
We present mCSEA, an R package that implements a Gene Set Enrichment Analysis method to identify DMRs from Illumina450K and EPIC array data. It is especially useful for detecting subtle, but consistent, methylation differences in complex phenotypes. mCSEA also implements functions to integrate gene expression data and to detect genes with significant correlations among methylation and gene expression patterns. Using simulated datasets we show that mCSEA outperforms other tools in detecting DMRs. In addition, we applied mCSEA to a previously published dataset of sibling pairs discordant for intrauterine hyperglycemia exposure. We found several differentially methylated promoters in genes related to metabolic disorders like obesity and diabetes, demonstrating the potential of mCSEA to identify DMRs not detected by other methods.

Availability and implementation
mCSEA is freely available from the Bioconductor repository.

Supplementary information
Supplementary data are available at Bioinformatics online.
“Mapping” Media Spaces: Smoothness, Striation, and the Expropriation of Desire in American Journalism from Postindustrial to Datafied Capitalism
Authors: Fitzgerald Andrew Arthur 
Published: February 2019

AbstractThe future of journalism in the digital age is a major topic of both vocational and academic debate—as is the question of whether anything is “new” with the rise of the digital more broadly. This article argues for a redeployment of Deleuze and Guattari’s concepts of “smooth” and “striated” space. Conducting a synthesis of a new wave of scholarship on digital journalism with the body of “sociology of news” literature from the late 1970s and 1980s, it maps continuities and intensifications of processes in the interplay between journalistic desire and the constraints of liberal capitalism, while also noting a key shift in the relationship between journalism and dominant economic classes, concomitant with a new form of “datafied capitalism.”
BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway
Authors: Kayama Hisako , Tani Haruka , Kitada Shoko , Opasawatchai Anunya , Okumura Ryu , Motooka Daisuke , Nakamura Shota , Takeda Kiyoshi 
Published: February 2019

AbstractInappropriate activation of the IL-23 signaling pathway causes chronic inflammation through the induction of immunopathological Th17 cells in several tissues including the intestine, whereas adequate Th17 responses are essential for host defense against harmful organisms. In the intestinal lamina propria, IL-23 is primarily produced by innate myeloid cells including dendritic cells (DCs) and macrophages (Mϕs). However, the molecular mechanisms underlying the regulation of IL-23 production by these cells remains poorly understood. In this study, we demonstrated that BATF2 regulates intestinal homeostasis by inhibiting IL-23-driven T-cell responses. Batf2 was highly expressed in intestinal innate myeloid subsets, such as monocytes, CD11b+ CD64+ Mϕs and CD103+ DCs. Batf2−/− mice spontaneously developed colitis and ileitis with altered microbiota composition. In this context, IL-23, but not TNF-α and IL-10, was produced in high quantities by intestinal CD11b+ CD64+ Mϕs from Batf2−/− mice compared with wild-type mice. Moreover, increased numbers of IFN-γ+, IL-17+ and IFN-γ+ IL-17+ CD4+ T cells, but not IL-10+ CD4+ T cells, accumulated in the colons and small intestines of Batf2−/− mice. In addition, RORγt-expressing innate lymphoid cells were increased in Batf2−/− mice. Batf2−/−Rag2−/− mice showed a reduction in intestinal inflammation present in Batf2−/− mice. Furthermore, the high numbers of intestinal IL-17+ and IFN-γ+ IL-17+ CD4+ T cells were markedly reduced in Batf2−/− mice when introducing Il23a deficiency, which was associated with the abrogation of intestinal inflammation. These results indicated that BATF2 in innate myeloid cells is a key molecule for the suppression of IL-23/IL-17 pathway-mediated adaptive intestinal pathology.
The Experience With Flow Diverters in the Treatment of Posterior Inferior Cerebellar Artery Aneurysms
Authors: Atallah Elias , Saad Hassan , Li Jonathan , Kumar Ayan , Tjoumakaris Stavropoula , Chalouhi Nohra , Hasan David , Zarzour Hekmat , Herial Nabeel , Gooch Michael Reid , Rosenwasser Robert H , Jabbour Pascal 
Published: February 2019

ABSTRACT

BACKGROUND
The use of the pipeline embolization device (PED; Medtronic, Dublin, Ireland) in the posterior circulation has been limited and infrequently reported compared to other off-label utilizations. Posterior inferior cerebellar artery aneurysms (PICAA) constitute 1 of the least reported posterior circulation aneurysms treated with PED. No clinical studies have addressed the treatment of these aneurysms with flow diversion exclusively.

OBJECTIVE
To appraise the feasibility and the safety of PED in the treatment of PICAAs.

METHODS
Data on 12 consecutive patients, treated between 2011-2017 with PED for their PICAA, was retrospectively reviewed. To control confounding, we used multivariable logistic regression and propensity score conditioning.

RESULTS
Of 534 patients, 12 (9/12, 75% males) were identified and constituted our study population. The average aneurysm size was 8.47 mm (SD = 2.6, 3.7-14). Patients were followed-up for an average of 10.3 months (SD = 11 mo). Two of 12 (16.7%) had a prior history of subarachnoid hemorrhage. Eight of 12 (67%) of the aneurysms were saccular, 3/12 (25%) were dolichoectatic, and 1/12 (8%) was a small blister aneurysm. Eleven of 12 (92%) aneurysms were treated with 1 PED; 2/12 (16.7%) patients received combined pipeline assisted coiling. All patients had a complete occlusion, regression, and resolution of their aneurysm(s). PED deployment was neither complicated with any hemorrhagic or clinically significant thromboembolic events nor with device migration in any of our patients. Three of 12 (25%) patients had a benign intrastent stenosis. No mortality, among our 12 patients, was noted throughout the follow-up period.

CONCLUSION
PED, deployed by specialized experts, should be safe in treating PICAA. It can be contemplated as a novel alternative treatment of aneurysms located at the PICA-VA bifurcation or within the PICA.
Support, information, and integration of genetics for children with congenital lower limb deficiencies in British Columbia, Canada
Authors: Campbell Teresa , Chen Ching-Yi (Jenny) , Chhina Harpreet , Chahal Rajpreet , Cooper Anthony , Elliott Alison M 
Published: February 2019

Abstract

Objectives
Children and families affected by congenital limb deficiencies (CLD) require a unique level of emotional support from diagnosis through to adolescence. The following study aims to collect data on Canadian paediatric patients affected by a CLD followed at BC Children’s Hospital (BCCH), Department of Orthopaedics.

Methods
Parents of children with a CLD were asked to complete a written questionnaire examining their experiences. Qualitative and quantitative data were collected concerning parent satisfaction with patient referrals, emotional support, and knowledge of their child’s diagnosis.

Results
Twenty-five completed questionnaires were returned. Fifty per cent of the parents reported they were either very satisfied, or satisfied, with the emotional support provided by health care providers (HCPs). Twenty-five per cent of the parents were unsatisfied with the emotional support received by HCPs. Forty-eight per cent of the parents could not recall the specific name of their child’s diagnosis; 20% of the parents reported their child did not have diagnosis. All the patients in our study had received a clinical diagnosis. Twenty-eight per cent of the parents in this study were also seen in medical genetics.

Conclusions
Families require additional resources for emotional support, peer support, and referrals to support organizations. Gaps in parent knowledge regarding their child’s CLD suggest the need for formalized communication strategies for HCPs. Furthermore, patients with CLDs and their families may benefit from improved communication between orthopaedic and medical genetic services at the time of diagnosis. Integration of genetic counsellors may improve emotional supports and education for families with regards to testing and reproductive planning.
Evaluating the Effectiveness of Survival Guides Among Student and New Nurse Practitioners
Authors: Hoffman Jenni L. 
Published: February 2019

Abstract
The transition between student and new nurse practitioner (NP) can be challenging. Survival guides given to student NPs may help ease the transition and make it a successful one. This study evaluates the effectiveness of survival guides in two student NP cohorts in the fall 2015 and fall 2016 semesters. Students completed a brief online survey at graduation, and three and six months after graduation. Results support the inclusion of survival guides in NP curricula as a creative way to positively support the transition from student to new NP and improve preparation for NP practice.