bluuebunny/crossref_metadata_2025_split huggingface dataset:
A quasi-experimental study evaluating a health promotion program targeting healthy nutrition, physical activity and social network enhancement for low-income multi-problem households: study protocol
Authors: Abidi Latifa , Nagelhout Gera E. , Spruijt Renate , Schutte Hermijn , De Vries Hein 
Published: July 2018

<p class="abstract"><strong>Background:</strong> Previous studies have shown that people living in multi-problem households are less physically active, eat less healthy, have unstable social networks, and worse self-perceived general health than other people. The aim of this paper is to describe the development and evaluation of a health promotion program called “Back2Balance” for low-income multi-problem households aimed at improving healthy nutrition, physical activity, social networks, and self-perceived health.</p><p class="abstract"><strong>Methods:</strong> The Back2Balance program was developed using input from two formative studies and a co-creation process together with the target group and social workers. We used the theoretical domains framework to identify the functional components of our program. The Back2Balance program consists of: 1) a walking group, 2) cooking workshops, 3) motivational talks, 4) discounts on existing health promotion programs, and 5) family trips and children’s activities. In a quasi-experimental study respondents in the intervention group receive the usual social services support for multi-problem households and have the possibility to enroll in the program. Respondents in the control group only receive usual social services support.<strong> </strong>The program will be evaluated among 272 respondents from low-income multi-problem households living in Apeldoorn, the Netherlands.</p><p class="abstract"><strong>Conclusions: </strong>This protocol describes the development and evaluation of the Back2Balance program. We hypothesize that the program will lead to increased physical activity, healthy nutrition, social networks enhancement, and self-perceived health. The results of this study can be used as input for other national or international initiatives aiming to increase health of low-income multi-problem households.</p><p class="abstract"><strong>Trial registration: </strong>NTR6512</p><p class="abstract"> </p>
Clinical trial of combination therapy for the efficacy, safety, tolerability and improvements in quality of life in patients with moderate to severe plaque psoriasis
Authors: G. V. Amruthavalli , V. Aruna , R. Gayathri 
Published: July 2018

<p class="abstract"><strong>Background:</strong> Psoriasis is an autoimmune disorder with clinical manifestations scales, inflammation and dryness. The psoriatic skin behaves differently in concurrence with circadian rhythm. Cell division increases in late night and early morning hours. Enzymatic activity will be more during day time. To balance these variations a 24×7 protection is required. The objective of the present study is to find the improvement in Psoriasis condition with the Combination therapy compared to single drug usage.</p><p class="abstract"><strong>Methods:</strong> A clinical trial for 4 weeks was conducted among psoriasis patients with psorolin oil vs. combination therapy (Dr. JRK’s 777 oil, psorolin ointment, psorolin oil and psorolin medicated bathing bar) and the clinical relief was measured among both groups by following parameters like psoriasis area and severity index (PASI), Physician’s global assessment (PGA), dermatology life quality index (DLQI), subjective self-assessment questionnaire (SSAQ) and subject investigational product feedback questionnaire (SIPFBQ).</p><p class="abstract"><strong>Results:</strong> Combination therapy (1-3-2 topical therapy) of Dr. JRK’s 777 oil, psorolin ointment, psorolin oil and psorolin medicated bathing bar as a treatment regimen was found to be more effective in the treatment of psoriasis.</p><p class="abstract"><strong>Conclusions: </strong>1-3-2 topical therapy is useful in severe psoriasis conditions and recommended for long term effective treatment of psoriasis.</p><p class="abstract"> </p>
An insight into the etiopathogenesis, clinical patterns, treatment outcome and repercussions of cutaneous small-vessel vasculitis
Authors: Kannan Rajkumar , Chandrasekar Muthusubramanian , Venu Sridhar , Vijayananth Jayakalyani 
Published: July 2018

<p class="abstract"><strong>Background:</strong> Cutaneous small-vessel vasculitis (CSVV) is a group of disorder which is characterised by involvement of capillaries, arterioles and venules. CSVV can be idiopathic or primary, or secondary to infection, drugs or as a part and parcel of underlying systemic disease. The aim of our study is to find out the etiological factors, treatment options and their outcome in CSVV.</p><p class="abstract"><strong>Methods:</strong> We analysed 75 cases of CSVV out of patients who attended Dermatology OPD, in a tertiary care-centre from April 2017 to March 2018.The study design was descriptive study. A detailed history taking, thorough clinical examination and appropriate relevant investigations including biopsy were done for all the patients fulfilling the inclusion criteria and exclusion criteria.<strong></strong></p><p class="abstract"><strong>Results:</strong> A sample size of 75 patients (53 women and 22 men) were included in the study. Their mean age was found to be 25 years (range 18-40). The following etiological factors were made out in our study: Benign isolated (40) patients, (53%), infective etiology (14) patients, (19%), vasculitis in background of ANA/dsDNA/ANCA positivity (12) patients, (16%), drug induced (9), patients (12%). The main clinical manifestations of CSVV in our study were found to be the following viz, palpable purpura in all 75 patients (100%), fever &amp; malaise in 30 patients, (40%), ulcers in 30 patients (40%) arthritis/arthralgia in 15 patients, (20%). After a median follow up of 6 months, complete recovery was observed in all patients, although relapses occurred in 8 patients (11%).</p><p><strong>Conclusions:</strong> CSVV is usually associated with other vasculitis and connective tissue disorders and patients turning ANCA positive somewhere in the course of the disease is of ominous sign and hence, it becomes mandatory to keep these patients on a long term vigil. </p>
Neonatal pemphigus vulgaris
Authors: Singh Santosh Kumar , Mohan Aayushi , Gupta Anil Kumar , Pandey Amit Kumar 
Published: July 2018

<p>Neonatal pemphigus is a transitory autoimmune blistering disorder caused by transplacental passage of maternal Auto antibodies to desmoglein to neonate through an affected mother. The association of maternal pemphigus vulgaris with neonate disease had been rarely reported. Herein, we report a case of neonatal pemphigus vulagris born to mother who conceived during active phase of disease. </p>
Wilson Prensipleri'nin Taşrada Küçük Bir Yansıması: Vilson Gazetesi
Authors: Bilgi Necdet 
Published: July 2018

I. Dünya
Savaşı’nın sonlarına doğru Amerikan Başkanı Woodrow Wilson, savaş sonrası dünya
düzeninin nasıl olması gerektiğine ilişkin 14 ilke açıkladı. Bu ilkeler, savaş
sonrasında mağlup ülkelerde ve özellikle Osmanlı’da ciddi yankı buldu. Birçok
aydın ülkenin kurtuluşunu bu ilkelerde gördü. Bunlardan bazıları Wilson
Prensipleri Cemiyeti’ni kurdular. Bu cemiyet vasıtasıyla Wilson’ın ve
ilkelerinin tanınması sağlandı. Wilson ve ilkelerinin ülkenin başkenti İstanbul
dışındaki yansımalarından en dikkate değer olanı Manisa’da ortaya çıktı. Batı
Anadolu’nun Yunan işgali tehlikesi yaşadığı sıralarda, Manisa’da Vilson adıyla
bir gazete yayınlandı. Manisa, basın tarihi açısından çok zengin bir geçmişe
sahip değildir. II. Meşrutiyet’in ilk yıllarından sonra ikinci basın hareketi
Mondros Mütarekesi döneminde görülür. Bu dönemin bilinen iki gazetesinden ilki
Vilson, ikincisi Ertuğrul’dur. Her iki gazete de, üç ay ara ile aynı kişi
tarafından çıkarılmıştır. Bu çalışma, elde ilk ve tek sayısı bulunan Vilson
gazetesini, hem Manisa basın tarihi açısından ve hem de dönemin gündemindeki
yeri açısından ele almayı amaçlamaktadır. Ayrıca gazete teknik ve içerik
yönünden de incelenecektir.&nbsp;
İstanbul'da Ev İçi Hizmetlerinde İstihdâm Edilen Kuzeybatı Anadolulu Kız Çocuklarının Göç Ağları Üzerine Bir Değerlendirme (1845-1911)*
Authors: Kokdaş İrfan , Araz Yahya 
Published: July 2018

1845-1911 tarihleri arasında, ev içi hizmetlerinde istihdâm edilen
Anadolulu kız çocuklarının Osmanlı başkenti İstanbul'a nasıl ulaştığı veya ulaştırıldığı
sorusunu irdeleyen bu çalışma, kız çocuklarının İstanbul’a olan göçlerindeki
dönüşüm ve devamlılıklara odaklanmaktadır. Makale, İstanbul ve çocukların
yaygın olarak geldikleri Anadolu kent ve kasabalarının mahkeme kayıtlarına,
devlet memurları arasındaki yazışmalara ve dönemin gazete ve dergilerine
dayanmaktadır. İstanbul’a çalışmaya gelen taşralı kız çocuklarının sayısı, 19.
yüzyıl boyunca artmış; bu artış kızların kente geliş mekanizmalarının
çeşitlenmesine yol açmıştı. 1880’lere değin, Anadolulu kız çocuklarının ev içi
hizmetlerinde çalışmak üzere İstanbul’a gelişlerinde, hemşehri ve akraba ağları
hâkim olurken; bu hareketlilik giderek aracıların aktif rol oynamaya başladığı
dinamik bir sektöre dönüşmüştü. 19. yüzyıldaki Osmanlı merkezileşme
politikaları, taşradaki devlet görevlilerinin sayısında önemli bir artışa sebep
olurken kız çocuklarının hareketliliğini de derinden etkilemişti.
Halil Paşa’nın Hatıralarının Tarihî Kıymeti
Authors: Marttin Volkan 
Published: July 2018

Tarih araştırmalarının kaynakları arasında hatıraların
farklı bir yeri vardır. Renksiz anlatımlara sahip arşiv belgelerinin suskun
kaldığı durumların açıklığa kavuşturulmasında hatıralar önemli roller
üstlenmektedir. Osmanlı Devleti’nin son zamanlarına ve Türkiye’nin Millî
Mücadele Dönemi’ne ait olaylar ile kişilerarası ilişkileri daha iyi görmek ve
anlamak adına Halil (Kut) Paşa’nın hatıratı büyük bir boşluğu doldurmaktadır. Halil
Paşa’nın atılgan ve cesur kişiliğiyle cepheden cepheye koşarak büyük
fedakârlıklarla yerine getirdiği vatan hizmeti bütün açıklığı ile hatıralarda
ortaya çıkmaktadır. 1967 yılından itibaren çeşitli zamanlarda yayınlanan, Kûtü’l-Amare
Zaferi’nin 100. Yılı münasebetiyle yeniden gündeme gelen Halil Paşa’nın hatıralarının
farklı baskıları mevcuttur. Bunlar arasında Akşam
gazetesinde tefrika halinde yayınlanan hatıraların daha değerli olduğunu
söylemek mümkündür. Başta askerî olmak üzere tarihin çeşitli kısımlarına
kazandıracağı önemli ayrıntılar nedeniyle Halil Paşa’nın hatıraları yeniden
değerlendirilmelidir. Bu sayede Trablusgarp, Balkan Savaşları, Birinci Dünya
Savaşı ve Türk Mücadele tarihleri daha ayrıntılı ve renkli olacaktır. &nbsp;&nbsp;&nbsp;
Küreselleşme Kavramının Siyasi Tarih Yazımına Etkileri
Authors: Sıvış Efe 
Published: July 2018

Küreselleşme
kavramının 1990’lı yıllardan itibaren akademik yazımda yoğun olarak
kullanıldığı ve söz konusu kavramın siyasi tarih yazımı üzerindeki etkisinin
belirginleştiği görülmektedir. Bu çalışmada; bireylerin, ürünlerin, hizmetlerin
ve bilginin ülkelerarası dolaşımının serbestleştiği bir süreç olarak
kavramsallaştırılan küreselleşmenin siyasi tarih yazımı üzerindeki etkileri ele
alınmaktadır. Toplumlar arası etkileşimin dramatik bir biçimde artması,
yaşanılan ortak gezegenin tarihinin yazılması ihtiyacını beraberinde
getirmiştir. Bu ihtiyaca yanıt vermesi beklenen yaklaşım olarak küresel tarih
yazımı öne çıkmaktadır. Çalışmada küresel tarihin selefi olarak konumlandırılan
dünya tarihi yazımının temel özellikleri incelenmiştir; Bunlar Batı merkezli
yaklaşım, ulus devlet temelli yaklaşım, modernleşme teorisi eksenli
yaklaşımlardır. Makalenin ana sorusu, küreselleşmenin etkisindeki tarih
yazımında bu özelliklerde bir dönüşümün yaşanıp yaşanmayacağıdır. Çalışmada dünya
tarihi yazımının özelliklerinin bir biçimde dönüşüm geçirecekleri savunulmakta
ve söz konusu dönüşümün niteliği üzerinden tartışmalar yürütülmektedir. Bununla
beraber küresel tarih perspektifiyle gerçekleştirilmiş çalışmalardan örnekler
verilmiş, söz konusu çalışmaların geleneksel dünya tarihi anlayışından farklı
olan yönleri ortaya konulmuştur.
Bu Dünyadan Bir Necat Çetin Geçti
Authors: Çelebi Mevlüt , Bilgi Nejdet 
Published: July 2018

Necat Çetin ile 1983 yılında Ege Üniversitesi
Edebiyat Fakültesi Tarih Bölümü’nün ikinci sınıfına geçince tanıştık.
Sınıfımıza Erzurum’dan yatay geçişle gelen bir arkadaşımızdı. Sanki birinci
sınıfı da beraber okumuşuz gibi, kısa süre içerisinde hepimizle kaynaşan Necat,
samimi, içten ve yardım sever bir kişilikti. Sınıfça kendisine “Arap Kadri”
lakabını takmıştık. Rahmetli arkadaşımızın hatırladığımız özelliklerinden biri
de, akademisyen olma arzusuydu. Bilhassa Osmanlı tarihine ilgisi vardı ve
alanla ilgili çalışan hocalarımızla sıkı ilişki içerisindeydi.
Malazgirt Savaşı’nın Tarihine Dair Kişisel Bir Değerlendirme
Authors: Kaya Pınar 
Published: July 2018

Batılı Ortaçağ ve günümüz
tarihçileri tarafından çok az bilinmesine rağmen, Malazgirt Savaşı, bir sınır
şehri olan Malazgirt’in güneydoğusunda bulunan tepeler ve ovalar ile Murat
Nehri’ne (Murat Nehri, Fırat Nehri’nin bir koludur)karışan iki nehir kolunun aktığı düzlükte, IV. Romanos Diogenes ve Alp Arslan
arasında 26 Ağustos 1071’de gerçekleşmiş olup, şüphesiz Bizans ve İslâm dünyası
arasında büyük sonuçlar doğuran en önemli tarihî temaslardan biri olmuştur. Bu
nedenle Malazgirt Savaşı; Bizans, Ermeni, Gürcü, Kürt, Arap, İran, Selçuklu, Uz,
Peçenek, Slav ve Norman tarihi ile ilgili olan tüm tarihçi ve dilbilimcilerin dikkate
değer bir şekilde ilgisini çekmiştir
The effect of pain management in laparoscopic cholecystectomy on recovery parameters
Authors: Güven Aytac Betül , Aytaç İsmail , Lafçı Ayşe , Postacı Aysun , Dikmen Bayazit 
Published: July 2018

Aim: We aimed to observe
the effects of analgesics used intraoperatively on the postoperative pain and
recovery in patients underwent LC . Material and
Methods: ASA
I-III group, aged 20-85 patients, who underwent LC surgery were included in the
study. We denominated
as groups the distribution of analgesics used in eight groups: control
group(Group C) for patients without intraoperative analgesia; tramadol (Group
T); metamizole (Group M); diclofenac (Group D); paracetamol (Group P);
tramadol+metamizol (Group TM); tramadol+diclofenac (Group TD);
tramadol+paracetamol (Group TP). Analgesics that can provide visual
analog scale (VAS) ≤ 4 was considered effective. Additional analgesics were
administered to the patients whom VAS was above 4 in recovery room.
Recoveries of patients was determined with Aldrete Score. Results: 31 patients control
group, in 35 patients tramadol, in 36 patients, metamizole, in 32 patients
diclofenac and in 31 patients paracetamol, in 56 patients
tramadol+metamizol, in 31 patients
tramadol+diclofenac and in 32 patients tramadol+paracetamol were used. In all groups
used analgesics, VAS≤ 4 could not be provided in first hour. In the patients
used one analgesic alone and two analgesics together, lowest need for
additional analgesics was in GP and GTP group
within the first one hour. Aldrete scores were lowest in whom did not
receive analgesics intraoperatively.

Conclusion: We consider that
the management of pain in laparoscopic cholecystectomy should be done early
postoperative period. All analgesics should be administered on the basis of the
knowledge of their pharmacokinetic profiles.
Cardiac amyloidosis: The great masquerader
Authors: Rind Jubran , Chalfoun Nagib , McNamara Richard 
Published: July 2018

Cardiac amyloidosis is an elusive condition that is notorious for mimicking various cardiovascular conditions that present with left ventricular hypertrophy (LVH). The hypertrophy in amyloidosis is typically diffuse; however, rare reports of echocardiographic resemblances with hypertrophic cardiomyopathy (HCM) exist, such as asymmetric septal hypertrophy and left ventricular outflow tract obstruction. Cardiac MRI can help differentiate amyloidosis from hypertrophic cardiomyopathy in unclear situations. This differentiation from HCM and other forms of cardiomyopathy has important treatment implications. Here we present the case of a 76-year-old man with cardiomyopathy who had echocardiographic features of asymmetric hypertrophic cardiomyopathy but was correctly diagnosed with amyloidosis with the help of cardiac MRI and ECG.
A Holistic View to Develop Descriptive Sheets for Argentinean Clover and Eucalyptus Unifloral Honey
Authors: Ciappini María C. , Calviño Amalia 
Published: July 2018

Background:
Honey is a complex natural product that varies not only in sensory properties
but also in chemical composition. The apiculture industry is interested in offering unifloral honey with
specific palynological, physicochemical and sensory characteristics. However, to the best of our
knowledge, no proper study has been reported in Argentina in this regard so far.

Objective:
The aim of this study was to develop descriptive sheets analyzing and compiling previous
palynological, physicochemical and sensory data obtained from Argentine eucalyptus and clover
unifloral honeys.

Methods:
The analysis included predominant and main secondary pollens; physicochemical characteristics
as moisture content, acidity, ash content, electrical conductivity, fructose, glucose, maltose and
sucrose, optical rotation and colour; antioxidant indicators as DPPH, TEAC, FRAC, OH; content of
phenolic and flavonoids compounds and the main sensory descriptors like colour, smell, aromatic
notes, sweetness and persistence.

Results:
The analysis was made by gathering 30 Eucalyptus honey (Eucalyptus spp.) and 55 clover
honey (Trifolium sp.). Forty-one morphological pollen types were recognized. The set of physicochemical
measures for honey met quality specifications for international marketing. Colour and odour
intensity, higher for eucalyptus honey, were identified as the main differentiating sensory attributes.

Conclusion:
An holistic analysis of all these properties allows to determine quality and certification of
Argentinean eucalyptus and clover unifloral honey. The intervals of variation of selected palynological,
physicochemical and sensory variables gathered in the descriptive sheets allow us to decide
whether or not a sample of honey can be classified as belonging to one of these floral origins.
Hydroxysafflor Yellow A Reprograms TLR9 Signalling Pathway in Ischaemic Cortex after Cerebral Ischaemia and Reperfusion
Authors: Gong Zhe , Pan Jingrui , Li Xiangpen , Wang Hongxuan , He Lei , Peng Ying 
Published: July 2018

Background and Objective: Hydroxysafflor yellow A (HSYA) was reported to suppress inflammation
in ischaemic microglia. However, the mechanism through which HSYA inhibits inflammation
caused by cerebral ischaemia and reperfusion injury remains unknown. Here, we have mimicked
acute cerebral ischaemia and reperfusion injury by subjecting male Sprague-Dawley rats to transient
middle cerebral artery occlusion for 90 minutes and have demonstrated that toll-like receptor 9
(TLR9) was upregulated from day 3 after reperfusion, accompanied by the persistent activation of the
pro-inflammatory nuclear factor-κB (NF-κB) pathway from 6 hours to day 7. HSYA was injected intraperitoneally
at a dose of 6 mg/kg per day, which activated TLR9 in microglia of ischaemic cortex at
6 hours after reperfusion and then obviously suppressed the NF-κB pathway from day 1 to day 7.
Meanwhile, HSYA also activated the anti-inflammatory pathway through interferon regulatory factor
3 from day 1 to day 3. The anti-inflammatory effect of HSYA was partially reversed by TLR9-siRNA
interference in primary microglia, which was stimulated by oxygen-glucose deprivation and reoxygenation
treatment. The regulation of TLR9-mediated inflammation by HSYA was consistent with the
recovery of neurological deficits in rats.

Conclusion:
Therefore, our findings support that HSYA exerts anti-inflammatory effects by reprogramming
the TLR9 signalling pathway during treatment of acute cerebral ischaemia and reperfusion
injury.
Exploring the Impact of Climate Variability on Malaria Transmission Using a Dynamic Mosquito-Human Malaria Model
Authors: Abiodun Gbenga J. , Witbooi Peter J. , Okosun Kazeem O. , Maharaj Rajendra 
Published: July 2018

Introduction:
The reasons for malaria resurgence mostly in Africa are yet to be well understood. Although the causes are often linked to regional climate change, it is important to understand the impact of climate variability on the dynamics of the disease. However, this is almost impossible without adequate long-term malaria data over the study areas.

Methods:
In this study, we develop a climate-based mosquito-human malaria model to study malaria dynamics in the human population over KwaZulu-Natal, one of the epidemic provinces in South Africa, from 1970-2005. We compare the model output with available observed monthly malaria cases over the province from September 1999 to December 2003. We further use the model outputs to explore the relationship between the climate variables (rainfall and temperature) and malaria incidence over the province using principal component analysis, wavelet power spectrum and wavelet coherence analysis. The model produces a reasonable fit with the observed data and in particular, it captures all the spikes in malaria prevalence.

Results:
Our results highlight the importance of climate factors on malaria transmission and show the seasonality of malaria epidemics over the province. Results from the principal component analyses further suggest that, there are two principal factors associated with climates variables and the model outputs. One of the factors indicate high loadings on Susceptible, Exposed and Infected human, while the other is more correlated with Susceptible and Recovered humans. However, both factors reveal the inverse correlation between Susceptible-Infected and Susceptible-Recovered humans respectively. Through the spectrum analysis, we notice a strong annual cycle of malaria incidence over the province and ascertain a dominant of one year periodicity. Consequently, our findings indicate that an average of 0 to 120-day lag is generally noted over the study period, but the 120-day lag is more associated with temperature than rainfall. This is consistence with other results obtained from our analyses that malaria transmission is more tightly coupled with temperature than with rainfall in KwaZulu-Natal province.
FORMULATION AND EVALUATION OF NANOSUSPENSION OF ROSUVASTATIN CALCIUM
Authors: Raturi Ankita , Bhatt Ganesh , Kothiyal Preeti 
Published: July 2018

Poor water solubility and slow dissolution rate are issues for majority of upcoming and existing biologically active compounds. The aim of present work was to increase the dissolution rate of Rosuvastatin Calcium, a poorly water soluble drug and hence improve its oral bioavailability by Nanosuspension technology. Nanosuspension is new carrier free colloidal drug delivery system with nano sized particles below 1000 nm, and considered as a great drug delivery technique to enhance the drug dissolution and solubility. In the present work Nanosuspension is made by nanoprecipitation technique in the presence of sodium lauryl sulfate as surfactant and PVPK-30 as stabilizer. Prepared Nanosuspension was evaluated for its particle size study, in vitro dissolution study and characterized by Screening Electron microscopy (SEM).
Different concentrations of sodium lauryl sulphate (SLS) and PVPK-30 were evaluated. All formulations were in the nano size and showed marked improvement in dissolution and solubility compared to pure drug of micron size. Finally it was concluded that formulating poorly soluble drugs in the form of Nanosuspension would be a promising approach in delivery of poor water soluble drugs by oral route in a simple and effective way.