bluuebunny/crossref_metadata_2025_split huggingface dataset:
UNC-10/SYD-2 links kinesin-3 to RAB-3-containing vesicles in the absence of the motor’s PH domain
Authors: Bayansan Odvogmed , Bhan Prerana , Chang Chien-Yu , Barmaver Syed Nooruzuha , Shen Che-Piao , Wagner Oliver Ingvar 
Published: August 2019

ABSTRACTKinesin-3 KIF1A (UNC-104 inC. elegans) is the major axonal transporter of synaptic vesicles and mutations in this molecular motor are linked to KIF1A-associated neurological disorders (KAND) including Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis and hereditary spastic paraplegia. UNC-104 binds via its PH (pleckstrin homology) domain to the lipid bilayers of membranous vesicles which is considered a weak interaction. RT-PCR and Western blot experiments reveal genetic relations between SYD-2, UNC-10 and RAB-3. Co-immunoprecipitation assays reveal functional relations and bimolecular fluorescence complementation (BiFC) assays exposein situinteractions between these proteins. Though both SNB-1 and RAB-3 are actively transported by UNC-104, the movement of RAB-3 is generally enhanced and largely depending on the presence of SYD-2/UNC-10. Deletion of UNC-104’s PH domain did not affect UNC-104/RAB-3 colocalization but did affect UNC-104/SNB-1 colocalization. Similarly, motility of RAB-3-labeled vesicles is unaltered in nematodes carrying a point mutation in the PH domain while movement of SNB-1 is significantly reduced in anterograde directions. These findings suggest a dual UNC-10/SYD-2 linker acting as a sufficient buttress to connect the motor to RAB-3-containing vesicles to enhance their transport. This additional linker will also strengthen the rather weak motor-lipid interaction.Graphical abstract
PTP-3(LAR PTPR) promotes intramolecular folding of SYD-2(liprin-α) to inactivate UNC-104(KIF1A) in neurons
Authors: Shanmugam Muniesh Muthaiyan , Barmaver Syed Nooruzuha , Huang Hsin-Yi , Wagner Oliver Ingvar 
Published: August 2019

AbstractThis study aims to demonstrate how PTP-3 regulates SYD-2 to control UNC-104-mediated axonal transport. UNC-104 is theC. eleganshomolog of kinesin-3 KIF-1A known for its fast shuttling of STVs (synaptic vesicle protein transport vesicles) in axons. SYD-2 is the homolog of liprin-α inC. elegansknown to directly regulate UNC-104 as well as being a substrate of LAR PTPR (leukocyte common antigen-related (LAR) protein tyrosine phosphatase (PTP) transmembrane receptor) with PTP-3 as the closest homolog inC. elegans. CoIP assays revealed increased interaction between UNC-104 and SYD-2 in lysates fromptp-3knockout worms. Intramolecular FRET analysis revealed that SYD-2 predominantly exists in an open conformation state inptp-3mutants. These assays also revealed that non-phosphorylatable SYD-2 (Y741F) exists predominately in folded conformations while phosphomimicking SYD-2 (Y741E) exists predominantly in open conformations. Inptp-3mutants, SNB-1 cargo accumulates in soma while at the same time UNC-104 motors increasingly cluster along initial segments of axons. Interestingly, the unc-104 gene is downregulated inptp-3mutants that might explain the vesicle retention phenotype. More strikingly, the few visibly moving motors and STVs were overly active in neurons of these mutants. We propose a model in which the lack of PTP-3 promotes increased open conformations of SYD-2 that in turn facilitates UNC-104/SYD-2 interactions boosting motor and STVs moving speeds.
Solutions of time-fractional third- and fifth-order Korteweg–de-Vries equations using homotopy perturbation transform method
Authors: Karunakar Perumandla , Chakraverty Snehashish 
Published: August 2019

Purpose
This study aims to find the solution of time-fractional Korteweg–de-Vries (tfKdV) equations which may be used for modeling various wave phenomena using homotopy perturbation transform method (HPTM).

Design/methodology/approach
HPTM, which consists of mainly two parts, the first part is the application of Laplace transform to the differential equation and the second part is finding the convergent series-type solution using homotopy perturbation method (HPM), based on He’s polynomials.

Findings
The study obtained the solution of tfKdV equations. An existing result “as the fractional order of KdV equation given in the first example decreases the wave bifurcates into two peaks” is confirmed with present results by HPTM. A worth mentioning point may be noted from the results is that the number of terms required for acquiring the convergent solution may not be the same for different time-fractional orders.

Originality/value
Although third-order tfKdV and mKdV equations have already been solved by ADM and HPM, respectively, the fifth-order tfKdV equation has not been solved yet. Accordingly, here HPTM is applied to two tfKdV equations of order three and five which are used for modeling various wave phenomena. The results of third-order KdV and KdV equations are compared with existing results.
Theoretical and numerical models for the influence of debonding on the interaction between hydraulic fracture and natural fracture
Authors: Wang Tao , Liu Zhanli , Gao Yue , Ye Xuan , Zhuang Zhuo 
Published: August 2019

Purpose
The interaction between hydraulic fracture (HF) and natural fracture (NF) in naturally fractured rocks is critical for hydraulic fracturing. This paper aims to focus on investigating the development of tensile and shear debonding zone on the NF caused by the stresses produced by HF, and the influence of NF’s debonding behavior on the interaction between HF and NF.

Design/methodology/approach
Theoretically, tensile and shear debonding modes of NF are considered, two dimensionless parameters are proposed to characterize the difficulty of tensile and shear failure of NF, respectively. Numerically, a finite element model combining the extended finite element method and cohesive zone method (CZM) is proposed to study NF’s debonding behavior and its influence on the interaction between HF and NF.

Findings
Both theoretical analysis and numerical simulation show the existence of two debonding modes. The numerical results also show that the HF can cross, offset or propagate along the NFs depending on the parameters’ value, resulting in different fracture network and stimulated reservoir volume. When they are large, the NF’s debonding area is small, HF tends to cross the NF and the fracture network is simple; when they are small, the NF’s debonding area is large, HF will propagate along the NF. In addition, HF is easier to propagate along with NF under tensile debonding mode while it is easier to pass through NF under shear debonding mode.

Originality/value
The theoretical and numerical considerations are taken into account in the influence of the debonding of NFs on the interaction between HFs and NFs and the influence on the formation of the fracture network.
A stable high-order absorbing boundary based on continued fraction for scalar wave propagation in 2D and 3D unbounded layers
Authors: Li Huifang , Zhao Mi , Wu Lihua , Wang Piguang , Du Xiuli 
Published: August 2019

PurposeThe purpose of this paper is to propose a stable high-order absorbing boundary condition (ABC) based on new continued fraction for scalar wave propagation in 2D and 3D unbounded layers.Design/methodology/approachThe ABC is obtained based on continued fraction (CF) expansion of the frequency-domain dynamic stiffness coefficient (DtN kernel) on the artificial boundary of a truncated infinite domain. The CF which has been used to the thin layer method in [69] will be applied to the DtN method to develop a time-domain high-order ABC for the transient scalar wave propagation in 2D. Furthermore, a new stable composite-CF is proposed in this study for 3D unbounded layers by nesting the above CF for 2D layer and another CF.FindingsThe ABS has been transformed from frequency to time domain by using the auxiliary variable technique. The high-order time-domain ABC can couple seamlessly with the finite element method. The instability of the ABC-FEM coupled system is discussed and cured.Originality/valueThis manuscript establishes a stable high-order time-domain ABC for the scalar wave equation in 2D and 3D unbounded layers, which is based on the new continued fraction. The high-order time-domain ABC can couple seamlessly with the finite element method. The instability of the coupled system is discussed and cured.
Fragility curves production by seismic improvement of the high-dimensional model representation method
Authors: Asadi Payam , Sourani Hosein 
Published: August 2019

Purpose
In the absence of random variables, random variables are generated by the Monte Carlo (MC) simulation method. There are some methods for generating fragility curves with fewer nonlinear analyses. However, the accuracy of these methods is not suitable for all performance levels and peak ground acceleration (PGA) range. This paper aims to present a method through the seismic improvement of the high-dimensional model representation method for generating fragility curves while taking advantage of fewer analyses by choosing the right border points.

Design/methodology/approach
In this method, the values of uncertain variables are selected based on the results of the initial analyses, the damage limit of each performance level or according to acceptable limits in the design code. In particular, PGAs are selected based on the general shape of the fragility curve for each performance limit. Also, polynomial response functions are estimated for each accelerogram. To evaluate the accuracy, fragility curves are estimated by different methods for a single degree of freedom system and a reinforced concrete frame.

Findings
The results indicated that the proposed method can not only reduce the computational cost but also has a higher accuracy than the other methods, compared with the MC baseline method.

Originality/value
The proposed response functions are more consistent with the actual values and are also congruent with each performance level to increase the accuracy of the fragility curves.
Punching in two-way RC flat slabs with openings and L section columns
Authors: Pinto Valdemir Colares , Branco Vitor , Oliveira Denio Ramam 
Published: August 2019

Purpose
This study aims to contribute to a better understanding of the influence of the position of openings around L cross-section columns in reinforced concrete flat slabs through a nonlinear computational analysis compared to experimental results.

Design/methodology/approach
Tests on four reinforced concrete flat slabs of 1800 x 1800 x 120 mm3 were carried out under symmetrical punching; one slab was referenced (without hole) and three had square holes of 100 x 100 mm2 close to columns and with centroid on the critical perimeter at 0.5 d and 2.0 d of the loaded area. A nonlinear analysis of the slabs was performed to aid the interpretation and preview of the experimental results, and to estimate the ultimate loads and failure modes. These estimates followed recommendations of ACI 318, Eurocode 2, NBR 6118, MC 2010 and critical shear crack theory.

Findings
The results showed that the presence of holes in the analyzed regions does not influence significantly the behavior of the slabs, leading to conservative structural design once the ultimate load estimates are low, while the computational results adequately estimated the slabs’ behavior.

Research limitations/implications
A few limitations were observed on how to implement the correct modeling system for computational nonlinear simulation.

Practical implications
All design codes underestimated failure loads and the theoretical method was not much better. The nonlinear computational simulations were satisfactory, presenting results close to experimental ones (97 per cent accuracy). Computational simulation also showed that the presence of holes does not significantly influence the load-vertical displacement behavior or failure loads.

Social implications
Structural and civil engineers and designers can observe with better details the punching phenomenon and make take secure decisions to building projects. They can preview accurate cases that are not cited in design codes and literature.

Originality/value
This is a very rare subject in literature that interests the entire scientific community and especially reinforced concrete designers. Presenting a new methodology to nonlinear flat slab with openings modeling to punching shear provoked by L cross section columns, case that is not cited in literature and design codes.
Corporate social responsibility: a pathway to sustainable competitive advantage?
Authors: Shah Syed Shujaat Ali , Khan Zia 
Published: August 2019

Purpose
The purpose of this paper is to investigate the impact of customers’ perceptions of corporate social responsibility (CSR) on affective and continuance commitment. It analyses the moderation effect of relationship age on the CSR-commitment relationships in the banking industry of an emerging economy.

Design/methodology/approach
Partial least squares based structural equation modeling was used to test the proposed hypotheses in a sample of 360 respondents collected from the retail banking sector of Pakistan.

Findings
Customers’ CSR perceptions directly and positively influence affective and continuance commitment. The findings also confirm that relationship age is a positive moderator of the CSR-continuance commitment relationship, but does not influence the CSR-affective commitment relationship.

Practical implications
Marketers should use CSR activities to enhance customers’ commitment. Given the moderating role of relationship age, marketers should devise different strategies for new and long-term customers. The results clearly show that relationship age affects the CSR-continuance commitment relationship. Long-term banking customers will more likely be in a binding relationship when their banks do CSR activities and disseminate those activities to long-term customers. The study explicitly indicates that maintaining long-term customers’ base through CSR activities helps the marketers in achieving sustainable competitive advantage.

Originality/value
First, it is the pioneering study to empirically investigate the understudied relationship between CSR and continuance commitment. Second, it examines the moderation effect of relationship age on CSR-commitment relationships in the banking industry of an emerging economy.
Measuring perceived procedural fairness in the context of power grid expansion
Authors: Mueller Christoph Emanuel , Keil Silke Inga 
Published: August 2019

PurposeGovernments and energy operators are often confronted with opposition to the construction of new high-voltage transmission lines. Besides other factors, a potential determinant of public opposition and acceptance that has gained increasing attention is the fairness of the planning and approval procedure as perceived by the citizens. The purpose of this study is to develop and validate a scale for measuring perceived procedural fairness (PPF).Design/methodology/approachThe authors developed the ten-item “perceived procedural fairness scale (PPFS)” and assessed its quality by means of item response theory. By using a Rasch rating scale model, the authors tested whether the instrument met the requirements of this kind of measurement model. For conducting their research, the authors used data from two telephone surveys in Germany that were collected in areas that are affected by grid expansion.FindingsThe findings suggest that the scale can be considered a reliable and internal valid instrument for measuring citizens’ PPF.Originality/valueAt the moment, there is no psychometrically rigorously evaluated scale available for measuring PPF in the context of power grid expansion. Therefore, the study contributes to filling this gap and provides a valuable tool for researchers and practitioners concerned with further investigating citizens’ PPF and its relationships with other relevant constructs in the field.
How can a low-income household procure small-scale hybrid renewable energy system?
Authors: Babatunde Olubayo Moses , Munda Josiah Lange , Hamam Yskandar 
Published: August 2019

Purpose
The application of hybrid renewable energy system (HRES) can mitigate inadequate access to clean, stable and sustainable energy among households in sub-Saharan Africa (SSA). Available studies on HRES seem to concentrate only on its techno-economic and environmental viability. In so doing, these studies do not seem to underline the likely challenges that follow the acquisition of HRES by especially low-income households. The ensuing reality is, of course, a limitation in the use of HRES in homes with low incomes. It is therefore imperative to analyze how a household with low income can afford this kind of energy system. The purpose of this study, therefore, lies in presenting a techno-economic, environmental and affordability analysis of how HRES is acquired.

Design/methodology/approach
To arrive at a grounded analysis, a typical household in SSA is used as an example. The analysis focused on the pattern of energy use, and this is obtained by visiting an active site to evaluate the comprehensive load profile. In the course of analysis, an optimal techno-economic design and sizing of a hybrid PV, wind and battery were undertaken. Additionally, an acquisition analysis was done based on loan amortization.

Findings
The interesting result is that a combination of the photovoltaic-gasoline-battery system is the most cost-effective energy system with a net present cost of $2,682. The system combination can lead to an emission reduction of approximately 98.3 per cent, compared to the use of gasoline generating sets, common mostly in SSA. If an amortized loan is used to purchase the energy system, and the payment plan is varied such that the frequency of payments is made quarterly, annually, semi-annually, bi-monthly, semi-monthly and bi-weekly, it will be observed that low-income household can conveniently acquire a HRES.

Originality/value
The result presented a framework by which a low-income household can purchase and install HRES. To facilitate this, it is recommended that low-income households should be given interest-friendly loans, so as to enhance the acquisition of HRES.
The next phase in servitization: transforming integrated solutions into modular solutions
Authors: Rajala Risto , Brax Saara A. , Virtanen Ari , Salonen Anna 
Published: August 2019

PurposeThe purpose of this paper is to identify integrated solutions business as the first generation of servitized offerings and modular solution offerings as the second development phase in servitization of original equipment manufacturers. This study examines how the servitized manufacturer, Kone, moves from integrated solutions to modular solutions business and develops the requisite capabilities to design, produce and implement modular solution offerings.Design/methodology/approachThe paper reports a longitudinal case study of a provider of integrated solutions installed in buildings. During the ten years studied, the manufacturer implemented a strategic initiative to modularize its integrated solutions offering.FindingsThe firm’s transition to modular solutions progressed through three major capability development phases: solutions based onad hocintegration, smart solutions based on modular design and through-chain modularity. The modular structure aims at fostering the efficiency of the solution offering and the associated production system.Research limitations/implicationsLeveraging the benefits of modularity calls for an aligned combination of strategic, operational and technical capabilities contributing to the integration of resources in a modular production system for the solution providers’ competitive performance.Practical implicationsThe study reports how a solution provider can develop the operational capabilities to integrate the core and peripheral components into the solution, and orchestrate the modular production system.Originality/valueThis study is a rare longitudinal analysis of how a manufacturer builds a modular offering, the solution platform and the required competitive capabilities to provide the solution.
Firm characteristics and export performance in Portuguese wine firms
Authors: Bashiri Behmiri Niaz , Rebelo João Fernandes , Gouveia Sofia , António Patrícia 
Published: August 2019

PurposeThe purpose of this paper is to contribute to the determinants of export performance literature. The authors investigate the effect of firm characteristics on the Douro region wine firms export performance. The authors consider the Douro region, as it has the Portugal highest wine classification, the appellation d’origine contrôlée and undertakes the first position in the Portuguese wine production and export.Design/methodology/approachThe authors apply a pooling cross-sectional data set that includes 427 observations. The authors pooled two cross sections consisting of 214 and 213 firms for the years 2014 and 215, respectively. The firm export intensity and propensity are the dependent variables. Moreover, the firm size, age and productive efficiency are accounted as the firm characteristics. The authors use the ordinary least squares regression and the tobit and probit models for estimations.FindingsFirst, size is an influential factor to improve the export performance, and the importance of size is higher for younger firms. Second, there is a positive response from export intensity to age and this response is higher for smaller firms. However, there is a negative response from the export propensity to age and this negative response is higher for bigger firms. Third, there is weak evidence to support a relationship between efficiency and export performance.Research limitations/implicationsThis research and the presented results are undoubtedly under some limitations. The main limitation is about the data availability for all characteristics of a firm. For example, it will enrich the result if the authors add some other important variables such as production cost, research and development expenditure and the quality of produced wine by each firm to our analysis.Originality/valueThis research reveals that the influence of firm characteristics on the export performance of Portuguese wine firms is missing in the literature. The results provide a basis to Portuguese wineries to improve their export performance by applying the relevant strategies.
What motivates Czech and international “millennial-aged” university students to consume craft beers?
Authors: Rivaroli Sergio , Kozák Vratislav , Spadoni Roberta 
Published: August 2019

Purpose
An interesting subset of millennials are university students. This study aims to investigate motivations to drink craft beers in a sample of Czech and International University students in Prague (Czech Republic).

Design/methodology/approach
Adopting a revised model of the theory of planned behaviour (TPB), a simultaneous equations model was used by performing a three-stage least squares (3SLS) regression. The data were obtained from 305 students of 18 and 35 years of age (152 Czechs and 153 Internationals) at the Czech University of Life Sciences (CULS), who completed a face-to-face interview using a questionnaire.

Findings
The findings confirm the major role played by self-identity (SI) on the intention to drink craft beers, in the whole sample, and the key role played by the perception of being able to drink, for the Czechs participants only. Attitudes and social pressure towards craft beer consumption are of secondary importance, whereas the desire for uniqueness is not a relevant aspect in the participants’ decision of drinking craft beers.

Originality/value
The study deepened the TPB by incorporating consumers’ SI and the desire for unique consumer products as additional constructs to explain the intention of drinking craft beers. Given the long tradition of brewing in the Czech Republic and its significant role in the global marketplace, the understanding of local and foreign millennials’ intention to drink craft beers would contribute to increase knowledge on consumer behaviour, bringing beneficial effects to the brewing sector. Further research developments, within the context of handcrafted food consumption, stem from the discussion of the theoretical implications.