bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incorporating a “Better” Behavioral Bias for Both Consumers and Firms in Rebate Programs
Authors: Chung Kevin 
Published: August 2019

We study a rebate program in the credit card industry where the firm automatically processed the rebate earned by consumers with flexible and effortless redemption opportunities in future transactions. Contrary to what the normative economic theory would predict, we document that consumers frequently failed to redeem their rebate. Given this observation, we examine what may have been the primary driving force behind this pattern and the implications for the firm. We provide evidence that the phenomenon that we observe in our study is a result of cardholders being influenced by the way their outcomes were framed. We find that redemption incidences coincide with episodes where rebates are a larger portion of the amount spent. On the basis of the empirical regularities, we formulate a model of cardholder behavior where the cardholder experiences increasing psychological utility when rebate redemption yields a deeper discount. The model estimates indicate that, although delayed redemption left customers monetarily worse off in each transaction (cardholders passed up on average $0.76 of card-level benefits to experience greater psychological utility), once the psychological utility is taken into account, customers were shown to fare better overall. For the firm, in addition to the card benefits that were passed up, the psychological utility generated an additional average benefit of $1.21 per redemption. Finally, through counterfactuals we show that carefully designing a rebate program that takes into account consumers’ psychological redemption utility can further benefit both consumers and firms. This paper was accepted by Juanjuan Zhang, marketing.
Surdez e sexualidade: Uma análise a partir das representações sociais de universitários surdos
Authors: Guimarães Valéria Maria Azevedo , Santos Fábio , Santos Bruno Felipe de Santana , Silva Joilson Pereira da 
Published: August 2019

O objetivo do presente estudo foi analisar as representações sociais dos surdos universitários acerca da sexualidade. Esta pesquisa teve como aporte teórico a Teoria das Representações Sociais (TRS), que possibilita compreender a sexualidade, além do aspecto individual, elucidando a função do saber compartilhado. Tratou-se de uma pesquisa descritiva, com abordagem qualitativa, realizada com cinco universitários surdos que foram entrevistados de forma individual, em Língua Brasileira de Sinais (Libras) e por meio de um roteiro semiestruturado. Utilizou-se o Software IRAMUTEQ para a análise dos dados mediante a Classificação Hierárquica Descendente (CHD). Observou-se que as representações sociais da sexualidade dos participantes estão ancoradas no cuidado com a saúde sexual, no futuro profissional e nas relações amorosas, nas relações com a comunidade surda e com os familiares. Com isso, foi identificado que os participantes tiveram preocupação com a afetividade, o bem-estar, a atividade sexual e a satisfação em seus relacionamentos. No entanto, percebe-se a necessidade de desmistificar a temática entre os jovens surdos para que esses desenvolvam a sexualidade com autonomia.
Concepções de famílias: Um estudo sobre as representações gráficas de crianças cariocas
Authors: Landim Ilana , Borsa Juliane Callegaro 
Published: August 2019

As configurações familiares estão em processo de diversificação, de maneira que o modelo formado por homem e mulher unidos em matrimônio não é o único a ser legitimado pela sociedade. Este estudo objetivou investigar de que forma as crianças cariocas representam graficamente as famílias, tomando como base a teoria da análise do comportamento. Participaram da amostra 108 crianças cariocas (52,8% meninos e 47,2% meninas), com idades entre cinco e 12 anos (M= 8,58; DP= 1,54) e seus respectivos responsáveis (M= 36,9; DP= 7,31). Foi solicitado que as crianças desenhassem individualmente uma família e a descrevessem. Aos responsáveis foi pedido que preenchessem um questionário sociodemográfico. Os conteúdos dos desenhos e os dados do questionário sociodemográfico foram tabulados e analisados por meio do software estatístico IBM SPSS versão 22. A maior parte das crianças representou famílias tradicionais em seus desenhos. No entanto, as concepções de família pareceram mais associadas à dimensão afetiva que aos espaços de convivência e moradia. Esse estudo propôs novas perspectivas empíricas e teóricas para avaliar o desenho da família e sugere a necessidade de melhor compreender como os diversos arranjos familiares são apreendidos pelas crianças.
Effect of critical shoulder angle, glenoid lateralization, and humeral inclination on range of movement in reverse shoulder arthroplasty
Authors: Lädermann Alexandre , Tay Eileen , Collin Philippe , Piotton Sébastien , Chiu Chih-Hao , Michelet Aude , Charbonnier Caecilia 
Published: August 2019

Objectives To date, no study has considered the impact of acromial morphology on shoulder range of movement (ROM). The purpose of our study was to evaluate the effects of lateralization of the centre of rotation (COR) and neck-shaft angle (NSA) on shoulder ROM after reverse shoulder arthroplasty (RSA) in patients with different scapular morphologies. Methods 3D computer models were constructed from CT scans of 12 patients with a critical shoulder angle (CSA) of 25°, 30°, 35°, and 40°. For each model, shoulder ROM was evaluated at a NSA of 135° and 145°, and lateralization of 0 mm, 5 mm, and 10 mm for seven standardized movements: glenohumeral abduction, adduction, forward flexion, extension, internal rotation with the arm at 90° of abduction, as well as external rotation with the arm at 10° and 90° of abduction. Results CSA did not seem to influence ROM in any of the models, but greater lateralization achieved greater ROM for all movements in all configurations. Internal and external rotation at 90° of abduction were impossible in most configurations, except in models with a CSA of 25°. Conclusion Postoperative ROM following RSA depends on multiple patient and surgical factors. This study, based on computer simulation, suggests that CSA has no influence on ROM after RSA, while lateralization increases ROM in all configurations. Furthermore, increasing subacromial space is important to grant sufficient rotation at 90° of abduction. In summary, increased lateralization of the COR and increased subacromial space improve ROM in all CSA configurations. Cite this article: A. Lädermann, E. Tay, P. Collin, S. Piotton, C-H Chiu, A. Michelet, C. Charbonnier. Effect of critical shoulder angle, glenoid lateralization, and humeral inclination on range of movement in reverse shoulder arthroplasty. Bone Joint Res 2019;8:378–386. DOI: 10.1302/2046-3758.88.BJR-2018-0293.R1.
Current trends in hernia surgery in NHS England
Authors: Pawlak M , Tulloh B , de Beaux A 
Published: August 2019

Background Mesh is recommended for the repair of most hernias when prevention of recurrence is the primary endpoint. However, mesh may be associated with increased complications for the patient. The aim of this study was to quantify the use of mesh for abdominal wall hernia surgery in NHS England in recent years. Materials and methods The NHS Digital Secondary Uses Service database for 2016/17 and 2017/18 was interrogated for numbers of patient undergoing elective primary hernia surgery. Using the specific hernia code inguinal (T201-9), umbilical (T241-9), incisional (T251-9) and other abdominal wall hernia (T271-9), the use of mesh or suture repair was determined. Recurrent and emergency hernia surgery were excluded. All data were provided by NHS RightCare. Results There are almost 100,000 hernia repairs performed annually in NHS England. For every four hernias, three are repaired with mesh. The percentage repaired by mesh varies by hernia type. Mesh repairs in inguinal, umbilical and incisional hernias accounted for 95%, 50% and 82%, respectively. Conclusions Mesh repair for all hernia types is more common than suture repair. However, for umbilical and other abdominal wall hernias, a significant proportion are repaired without the use of mesh.
On Teachers’ Professional Qualities Structure and Development Mechanisms in the Business English Discipline
Authors: Bao Wen 
Published: August 2019

Abstract
Business English is a newly developed applied discipline quite different from the traditional English discipline, and it requires different qualities for Business English teachers. This paper attempts to explore the specific professional qualities required of Business English teachers and put forward teacher development mechanisms for the purpose of promoting professionalism of Business English teachers and facilitating construction and development of the Business English discipline.
Continuous distributions whose functions preserve tails of an 𝐴-continued fraction representation of numbers
Authors: Pratsiovytyi Mykola , Chuikov Artem 
Published: August 2019

Abstract
We study continuous, strictly monotonic functions preserving tails of an A-continued fraction representation of real numbers.
We construct continuous transformations of

[

1
2

;
1
]

{[\frac{1}{2};1]}

using these functions.
They determine the probability distributions on this interval.
It is proved that the set of all transformations is infinite and forms a non-commutative group with respect to the operation of a composition (superposition).
Thus, a group of probability distributions is constructed on the interval.
These distributions have non-trivial local properties (self-similar structure).
Neonatal Injury Alters Sensory Input and Synaptic Plasticity in GABAergic Interneurons of the Adult Mouse Dorsal Horn
Authors: Li Jie , Baccei Mark L. 
Published: August 2019

Neonatal tissue injury disrupts the balance between primary afferent-evoked excitation and inhibition onto adult spinal projection neurons. However, whether this reflects cell-type-specific alterations at synapses onto ascending projection neurons, or rather is indicative of global changes in synaptic signaling across the mature superficial dorsal horn (SDH), remains unknown. Therefore the present study investigated the effects of neonatal surgical injury on primary afferent synaptic input to adult mouse SDH interneurons usingin vitropatch-clamp techniques. Hindpaw incision at postnatal day (P)3 significantly diminished total primary afferent-evoked glutamatergic drive to adult Gad67-GFP and non-GFP neurons, and reduced their firing in response to sensory input, in both males and females. Early tissue damage also shaped the relative prevalence of monosynaptic A- versus C-fiber-mediated input to mature GABAergic neurons, with an increased prevalence of Aβ- and Aδ-fiber input observed in neonatally-incised mice compared with naive littermate controls. Paired presynaptic and postsynaptic stimulation at an interval that exclusively produced spike timing-dependent long-term potentiation (t-LTP) in projection neurons predominantly evoked NMDAR-dependent long-term depression in naive Gad67-GFP interneurons. Meanwhile, P3 tissue damage enhanced the likelihood of t-LTP generation at sensory synapses onto the mature GABAergic population, and increased the contribution of Ca2+-permeable AMPARs to the overall glutamatergic response. Collectively, the results indicate that neonatal injury suppresses sensory drive to multiple subpopulations of interneurons in the adult SDH, which likely represents one mechanism contributing to reduced feedforward inhibition of ascending projection neurons, and the priming of developing pain pathways, following early life trauma.SIGNIFICANCE STATEMENTMounting clinical and preclinical evidence suggests that neonatal tissue damage can result in long-term changes in nociceptive processing within the CNS. Although recent work has demonstrated that early life injury weakens the ability of sensory afferents to evoke feedforward inhibition of adult spinal projection neurons, the underlying circuit mechanisms remain poorly understood. Here we demonstrate that neonatal surgical injury leads to persistent deficits in primary afferent drive to both GABAergic and presumed glutamatergic neurons in the mature superficial dorsal horn (SDH), and modifies activity-dependent plasticity at sensory synapses onto the GABAergic population. The functional denervation of spinal interneurons within the mature SDH may contribute to the “priming” of developing pain pathways following early life injury.
CIUDADES COMPACTAS Y VERDES: DISCUSIONES SOBRE LA CALIDAD DE VIDA Y LA SOSTENIBILIDAD URBANA
Authors: Alexandre da Silva Geovany Jessé , Ribeiro da Silveira José Augusto , Leite Ribeiro Edson 
Published: August 2019

El presente artículo hace un análisis de los aspectos positivos y negativos del modelo compacto, valiéndose de una comparación entre este y los principales planteamientos de la propuesta estadounidense denominada “smart growth” (crecimiento inteligente). El objetivo principal de la investigación fue explorar los dos modelos, estableciendo el impacto urbano que cada uno ha tenido sobre la naturaleza, el consumo de energía, el agotamiento de los espacios naturales y sobre la misma calidad de vida de los habitantes. En términos metodológicos, se tomaron como punto de partida algunas de las hipótesis que se han estructurado con base en la teoría disponible, así como ciertos índices de compactación urbana, utilizados internacionalmente. Mediante simulaciones se obtuvieron conclusiones relativas a la disponibilidad y accesibilidad de elementos cualitativos urbanos. Este método también permitió identificar la percepción que tiene la comunidad de dichos elementos. Los resultados obtenidos muestran que si bien en algunos casos los indicadores cuantitativos y cualitativos de un modelo urbano más expansivo pueden parecer mejores por la cantidad de espacio disponible (por ejemplo, áreas verdes), una aplicación más eficiente de estos se puede observar en un modelo más compacto, dado que esposible una mejor distribución de los espacios, correctamente dimensionados y oportunamente accesibles, para así optimizar su potencial de uso.
Fine Mapping Using Whole-Genome Sequencing Confirms Anti-Müllerian Hormone as a Major Gene for Sex Determination in Farmed Nile Tilapia (Oreochromis niloticus L.)
Authors: Cáceres Giovanna , López María E , Cádiz María I , Yoshida Grazyella M , Jedlicki Ana , Palma-Véjares Ricardo , Travisany Dante , Díaz-Domínguez Diego , Maass Alejandro , Lhorente Jean P , Soto Jose , Salas Diego , Yáñez José M 
Published: August 2019

Abstract
Nile tilapia (Oreochromis niloticus) is one of the most cultivated and economically important species in world aquaculture. Intensive production promotes the use of monosex animals, due to an important dimorphism that favors male growth. Currently, the main mechanism to obtain all-male populations is the use of hormones in feeding during larval and fry phases. Identifying genomic regions associated with sex determination in Nile tilapia is a research topic of great interest. The objective of this study was to identify genomic variants associated with sex determination in three commercial populations of Nile tilapia. Whole-genome sequencing of 326 individuals was performed, and a total of 2.4 million high-quality bi-allelic single nucleotide polymorphisms (SNPs) were identified after quality control. A genome-wide association study (GWAS) was conducted to identify markers associated with the binary sex trait (males = 1; females = 0). A mixed logistic regression GWAS model was fitted and a genome-wide significant signal comprising 36 SNPs, spanning a genomic region of 536 kb in chromosome 23 was identified. Ten out of these 36 genetic variants intercept the anti-Müllerian (Amh) hormone gene. Other significant SNPs were located in the neighboring Amh gene region. This gene has been strongly associated with sex determination in several vertebrate species, playing an essential role in the differentiation of male and female reproductive tissue in early stages of development. This finding provides useful information to better understand the genetic mechanisms underlying sex determination in Nile tilapia.
A História da Religião na Filosofia Positiva de Schelling – a tese tillichiana de 1910
Authors: Calvani Carlos Eduardo Brandão 
Published: August 2019

A obra de Paul Tillich é fortemente influenciada pela filosofia de Friedrich Schelling. O doutorado em Filosofia de Tillich, defendido em 1910 na Universidade de Breslau evidencia seu interesse nesse autor. Intitulado “A história da religião na Filosofia Positiva de Schelling”, a tese de 1910 só foi publicada em 1974, em inglês, com tradução de Victor Nuovo. Embora seja um texto de juventude, nele se enuncia um estilo de escrita que acompanhará o posterior amadurecimento de Tillich, bem como temas que serão aprofundados ao longo de sua trajetória, tais como a importância da história, da mitologia, a busca por identidade, o símbolo da queda, a encarnação e a profundidade da mensagem cristã como revelação da possibilidade de harmonização entre o ser humano e o Absoluto. O presente artigo apresenta um resumo dessa tese, com considerações pontuais que identificam elementos que posteriormente serão desenvolvidos por Tillich, e é resultado de um projeto de IC (Iniciação Científica) coordenado pelo autor principal e acompanhado pelo discente que providenciou a tradução da tese de 1910.Abstract The work of Paul Tillich is strongly influenced by the philosophy of Friedrich Schelling. Tillich’s doctorate in philosophy, defended in 1910 at the University of Breslau evidences his interest in this author. Entitled "The History of Religion in Schelling's Positive Philosophy," the 1910 thesis was only published in 1974, in English, with translation by Victor Nuovo. Although it is a text of his youth, it already enunciates a style of writing that will accompany the later maturation of Tillich’s work, with themes that will be deepened along his trajectory, such as the importance of history, mythology, the search for identity, the symbol of the fall, the incarnation and depth of the Christian message as revelation of the possibility of harmonization between humanity and the Absolute. The present article presents a summary of Tillich’s thesis, with specific considerations that identify elements that will later be developed by Tillich, and is the result of an IC project (Scientific Initiation) coordinated by the main author of this article and accompanied by the student who provided the translation of the 1910 thesis.
A Phase Ib Trial of Durvalumab in Combination with Trastuzumab in HER2-Positive Metastatic Breast Cancer (CCTG IND.229)
Authors: Chia Stephen , Bedard Phillipe L. , Hilton John , Amir Eitan , Gelmon Karen , Goodwin Rachel , Villa Diego , Cabanero Michael , Tu Dongsheng , Tsao Ming , Seymour Lesley 
Published: August 2019

AbstractBackgroundImmune checkpoint inhibitors are active in a broad range of cancers, including programmed death ligand 1 (PD-L1)-positive, triple-negative, metastatic breast cancer (MBC). Antibody-dependent cell-mediated cytotoxicity is a mechanism of action of trastuzumab. We performed a phase Ib trial of durvalumab and trastuzumab in HER2-positive MBC previously treated with chemotherapy and anti-HER2 antibodies to assess safety, efficacy, and correlative endpoints.Patients and MethodsPatients with HER2-positive MBC were enrolled on a standard 3 + 3 design. Dose level 1 was durvalumab (1,125 mg intravenously day 1) and trastuzumab (8 mg/kg intravenously loading, then 6 mg/kg day 1) on a q3 weekly cycle. An expansion cohort at the recommended phase II dose (RP2D) performed tumor biopsies at baseline and after cycle 1. The primary endpoint was to establish the RP2D.ResultsFifteen patients were accrued from April to December 2016, of which 14 were evaluable for response. Median age was 54 years (range 40–86); the majority had visceral disease (87%) and at least three prior (adjuvant and/or metastatic) lines of chemotherapy (73%), including trastuzumab (93%), pertuzumab (60%), and trastuzumab-emtansine (93%) for MBC. No dose-limiting toxicities were observed at dose level 1 (n = 6) or dose expansion (n = 9) during cycle 1. One patient developed a grade ≥3 immune-related adverse event (grade 4 diabetes mellitus). No responses by RECIST were seen, with 4 of 14 patients (29%) demonstrating stable disease as best response at week 6 (median duration, 2.7 months). All patients had &lt;1% PD-L1 expression on either archival tissue (7/15) or prestudy biopsy (8/15). In the dose expansion cohort, evaluable pretreatment and on-treatment tumor biopsies (n = 5) showed minimal CD8 cell infiltration.ConclusionThe RP2D of durvalumab and trastuzumab is standard full doses of both agents. No significant clinical activity was observed in patients with heavily pretreated HER2-positive PD-L1-negative MBC.Implications for PracticeThis phase Ib trial with associated correlative endpoints provides insights into the lack of activity of the combination of durvalumab and trastuzumab in heavily pretreated HER2-positive metastatic breast cancer (MBC). No significant clinical activity was observed in patients with heavily pretreated HER2-positive programmed death ligand 1 (PD-L1)-negative MBC with evidence of cytotoxic T-cell exhaustion. Furthermore, all patients had no expression of PD-L1 in the tumor cells. These data support the importance of PD-L1 as an important selection biomarker and the need to assess the tumor microenvironment for immune regulatory cells. Further work is needed to understand how to activate the “cold” tumors to be able to combine current immune-oncology agents.
La ingeniería en Colombia, ¿educación de calidad?: el cuarto objetivo de Desarrollo Sostenible de la ONU
Authors: Valdiri Luz Helena 
Published: August 2019

La formación educativa en ingeniería es un elemento indispensable para el desarrollo de un mundo sostenible. Los organismos internacionales han hecho especial hincapié en el conocimiento como herramienta primordial para mejorar las condiciones actuales en que vive la sociedad global. En este sentido, el cuarto Objetivo de Desarrollo Sostenible (ODS) tiene como propósito “garantizar una educación inclusiva y equitativa de calidad y promover oportunidades de aprendizaje a lo largo de la vida para todos”. A continuación, se presentan los principales logros en la inserción del cuarto ODS en las Facultades de Ingeniería de las universidades colombianas que ofrecen programas de ingeniería acreditados.