bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of epidural anaesthesia and analgesia on T lymphocytes differentiation markers and cytokines in patients after gastric cancer resection.
Authors: Wang Liping , Liang Si , Chen Hong , Xu Yang , Wang Yu 
Published: June 2019

Abstract
Background: Epidural use can prevent peri-operative neuro-endocrine stress responses, mitigate pain after surgery, and reduce opioid use, which all lead to immunosuppression. Methods: Forty patients with gastric cancer were ultimately enrolled into the study. Patients who received general anaesthesia (GA group, n=20) or a combination of general anaesthesia and peri-operative epidural use (EGA group, n=20) were given intravenous analgesia or epidural analgesia, respectively. We collected visual analogue scale (VAS) scores, length of hospital stay, the time of the first passage of flatus and incidence of postoperative nausea and vomiting (PONV). We also collected data on the cluster of differentiation markers (CD)3+, CD4+, CD8+, CD4+/CD8+, interleukin (IL)-4, IL-6, and interferon (IFN)-γ the day before surgery as well as on postoperative days 1, 3, and 7. Results: VAS scores and PONV in the GA group were higher than in the EGA group on postoperative day 3. CD3+, CD4+, and CD4+/CD8+ T cells declined on postoperative day 3 and nearly recovered to baseline seven days after surgery in both groups. CD3+ T cells decreased more in the GA group than in the EGA group. IL-4, IL-6, and IFN-γ increased on postoperative day 3 and nearly recovered to baseline seven days after surgery in both groups. IL-4 and IL-6 increased more in the GA group than in the EGA group. IFN-γ increased more in the EGA group than in the GA group. Conclusions: A combination of general anaesthesia and peri-operative epidural use can relieve postoperative pain and PONV. A combination of general anaesthesia and peri-operative epidural use decreases immunosuppression in gastric cancer resection.
Comparative Genomics of Mycoplasma pneumoniae isolated from Children with Pneumonia: South Korea, 2010-2016
Authors: Lee Joon Kee , Choi Eun Hwa , Seong Moon-Woo , Yeon Youbin , Cho Sung Im , Park Sung Sup 
Published: June 2019

Abstract
Background

Mycoplasma pneumoniae is a common cause of respiratory tract infections in children and adults. This study applied high-throughput whole genome sequencing (WGS) technologies to analyze the genomes of 30 M. pneumoniae strains isolated from children with pneumonia in South Korea during the two epidemics from 2010 to 2016 in comparison with a global collection of 48 M. pneumoniae strains which includes seven countries ranging from 1944 to 2017.

Results

The 30 Korean strains had approximately 40% GC content and ranged from 815,686 to 818,669 base pairs, coding for a total of 809 to 828 genes. Overall, BRIG revealed 99% to > 99% similarity among strains. The genomic similarity dropped to approximately 95% in the P1 type 2 strains when aligned to the reference M129 genome, which corresponded to the region of the p1 gene. MAUVE detected four subtype-specific insertions (three in P1 type 1 and one in P1 type 2), of which were all hypothetical proteins except for one tRNA insertion in all P1 type 1 strains. The phylogenetic associations of 30 strains were generally consistent with the multilocus sequence typing results. eBURST analysis demonstrated two clonal complexes which are accordant with the known P1 typing, with higher diversity among P1 type 2 strains. The phylogenetic tree constructed with 78 genomes including 48 genomes outside Korea formed three clusters, in which the sequence type 3 strains from Korea were divided into two P1 type 1 clusters.

Conclusions

The comparative genome analysis of the 78 M. pneumoniae strains including 30 strains from Korea by WGS reveals structural diversity and phylogenetic associations, even though the similarity across the strains was very high.
How Do Contrast Agents Affect Cardiac Markers and Coagulation Tests? Experimental Study
Authors: Tascanov Mustafa Begenc , Gönel Ataman 
Published: June 2019

Background:
The discovery that biotin interferes with results of troponin and Nt-proBNP led
some commercial firms to update their measurement methods. In particular, the clinical incompatibility of
cardiac test results may affect the risk of morbidity and mortality.

Objective:
The aim of this study is to investigate the interference effects of 7 different contrast agents on
cardiac markers (Troponin-I, Nt-proBNP, Mass CK-MB, CK, AST, LDH) and in coagulation tests (PT,
APTT).

Methods:
Seven different contrast media were added into control materials by using interference protocol.
The concentrations of PT, APTT, CK, AST, LDH, Mass CK-MB, Troponin-I, and Nt-proBNP were
measured by Sysmex CS-2100, Abbott c16000, Siemens Centaur XP and AFİAS-6 analyzer. The number
of deviations from target values was calculated.

Results:
The 7 different contrast media caused negative interference in troponin levels between 57.43%
and 62.87%. It was found that different contrast media produced false negativity in the Nt-proBNP test,
ranging from 6.11% to 96.01%. Enzymes and coagulation tests were less affected.

Conclusion:
Different contrast media may cause false negatives in cTnI and Nt-proBNP. The contrast
medium that causes the least interference should be preferred. The results of samples taken in the first hour
after contrast imaging should be interpreted with care.
Formulation and Characterization of Transethosomes for Enhanced Transdermal Delivery of Propranolol Hydrochloride
Authors: Kumar Lalit , Utreja Puneet 
Published: June 2019

Objective:
The objective of the present work was to develop transethosomes loaded with
propranolol hydrochloride using Lipoid S100 as phospholipid, and oleic acid as permeation enhancer
and evaluate them for prolonged release effect, in-vitro skin permeation, and in-vivo plasma concentration.

Methods:
Transethosomes loaded with propranolol hydrochloride were prepared by homogenization
method. Furthermore, they were characterized by using Transmission Electron Microscopy (TEM),
zeta sizer, Differential Scanning Calorimetry (DSC), and Confocal Laser Scanning Microscopy
(CLSM) for in-vitro skin permeation. Plasma concentration profile of transethosomal gel was determined
using Sprague Dawley rats and compared with a marketed oral tablet of propranolol hydrochloride.

Results:
Developed transethosomes loaded with propranolol hydrochloride showed acceptable size
(182.7 ± 5.4 nm), high drug entrapment (81.98 ± 2.9%) and good colloidal characteristics [polydispersity
index (PDI) = 0.234 ± 0.039, zeta potential = -21.91 ± 0.65 mV]. Transethosomes showed prolonged
in-vitro release of propranolol hydrochloride for 24 h. Results of in-vitro skin permeation studies
of transethosomal gel showed 74.34 ± 2.33% permeation of propranolol hydrochloride after 24 h
and confocal microscopy revealed accumulation of transethosomes in the stratum basale layer of the
skin. Transethosomal gel was capable to prolong the in-vivo release of propranolol hydrochloride upto
24 h. The value of peak plasma concentration (Cmax) of propranolol hydrochloride was found to be
93.8 ± 3.6 ng/mL which was very high compared to the marketed oral tablet of propranolol hydrochloride
(45.6 ± 3.1 ng/mL).

Conclusion:
The results suggested that transethosomal gel of propranolol hydrochloride could be a
better alternative to oral propranolol hydrochloride as it can avoid various disadvantages of oral propranolol
hydrochloride like high dosing frequency, first pass effect, and organ toxicity.
Imaginarios de Vejez: ¿Cómo Perciben la Vejez las Mujeres en Chile?
Authors: Undurraga Rosario , Cornejo Paula , Hornickel Natalia López , Benavides Michele 
Published: June 2019

El creciente envejecimiento de la población ha generado nuevas interrogantes respecto al proceso de envejecer y a las expectativas sobre la vejez. Este estudio cualitativo explora los imaginarios de vejez de mujeres chilenas y problematiza la (in)visibilidad de la heterogeneidad en la vejez. Se utilizan entrevistas semi-estructuradas a una muestra de 50 mujeres entre 24 y 88 años, profesionales y no-profesionales, de Santiago de Chile. Los resultados muestran imaginarios de vejez diferenciados cuando se trata de los demás (imaginarios sociales de vejez) respecto de aquellos referidos a la propia vejez (imaginarios individuales de vejez). Los imaginarios sociales de vejez tienden a ser negativos por: (a) las bajas pensiones, (b) mala atención en salud y (c) pérdida de autovalencia. Esto se contrapone con los imaginarios individuales de vejez, donde se articulan atributos positivos y negativos, resaltando la salud, los vínculos familiares y estrategias para mantenerse saludable y activa. Se concluye que las diferencias entre los imaginarios sociales e individuales de vejez darían cuenta de: tensiones en la definición de vejez, heterogeneidad en la vejez, cambios en las expectativas para la vejez de mujeres chilenas, cuestionamiento de las instituciones de previsión social, y la importancia de la familia y los cuidados en la vejez. AbstractThe increasing ageing population has generated new questions regarding the process of getting older and the expectations about old age. This qualitative study explores imaginaries about old age of Chilean women. It problematizes the (in)visibility of the heterogeneity of old age people. Semi-structured interviews were conducted with 50 professional and non-professional women from 24 to 88 year-old living in Santiago de Chile. The results show differences between social imaginaries of old age (referred to other old people) and individual imaginaries of old age (own old age). Social imaginaries of old age are negative due to: (a) economic precariousness and low pensions, (b) bad quality of the health system, and (c) the loss of autonomy. This contrasts with individual imaginaries of old age, where there are both positive and negative attributes, highlighting health, family ties and strategies to keep healthy and active. The paper concludes that the differences between social and individual imaginaries of old age show: tensions on the definition of old age, heterogeneity within adulthood, changes on the expectations of Chilean women about old age, the questioned role of social security, and the relevance of family and caring at old age.
DISEMINASI TEKNOLOGI PUPUK KANDANG SAPI PLUS RIZOBAKTERI PADA KELOMPOK TANI KAKAO DI KABUPATEN LIMAPULUH KOTA
Authors: Rahma Haliatur , Trisno Jumsu , Martinius Martinius , Reflin Reflin , Wahyuni Sri , Nusyirwan Nusyirwan 
Published: June 2019

Kegiatan diseminasi teknologi pupuk kandang sapi plus rizobakteri pada tanaman kakao dilakukan di Kecamatan Guguak dan Akabiluru Kabupaten Lima Puluh Kota yang dimulai dari bulan Maret sampai dengan November 2018. Kegiatan ini bertujuan untuk mengenalkan teknologi formulasi pupuk kandang plus rizobakteri pada kelompok tani kakao. Inovasi, buah lobek, maju sejahtera dan aroma menggunakan metode penyuluhan. Pentingny kegiatan ini dilakukan disebabkan oleh tingginya kejadian dan keparahan penyakit VSD di Kecamatan Guguak dan Akabiluru Kabuparten Limapuluh Kota yang mencapai 86,60%. Untuk itu, diperlukan teknologi pengendalian yang mudah dibuat, murah dan bahan baku yang mudah diperoleh disekitar petani. Penggunaan air kelapa merupakan salah satu perbanyakan bakteri Serratia maresescens dan Pseudomonas fluorescens yang nanti akan diformulasi dengan pupuk kandang. Kegiatan ini meliputi: pemantauan tingkat serangan OPT dilahan kelompok tani kakao, kemudian dilanjutkan dengan penyuluhan, pelatihan, dan evaluasi hasil kegiatan. Dari hasil kegiatan bahwa kegiatan ini mampu meningkatkan pengetahuan petani terhadap penggunaan biofertilizer yang berasal dari bakteri yang diformulasikan dengan air kelapa dan pupuk kandang, sehingga penggunaan formulasi ini mampu mengurangi biaya penggunaan pupuk kimia yang memiliki harga yang mahal.
Correction of pediatric flexible flatfoot using arthroereisis
Authors: Paes de Brito Leandro , Bittar Cíntia Kelly , Paulillo de Cillo Mário Sérgio , De Castro Filho Carlos Daniel Cândido , Reinig Carvalho Renê André , Do Nascimento Maria Augusta Back 
Published: June 2019

Objective: The aim of this study was to evaluate the effectiveness of arthroereisis using synthetic polyethylene implants as a method to correct deformities of excessive valgus in pediatric patients with flexible flatfoot (FF). Methods: This was a study of 20 patients between 5 and 12 years of age with symptomatic FF who received surgery between January 2011 and July 2016. Evaluations were made on the basis of the Valenti podoscopic classification, radiographic images, and AOFAS criteria. Patients with preoperative Valenti classification grades of III and IV were selected for the study. These patients received surgical treatment by arthroereisis with the interposition of a synthetic implant in the sinus tarsi, with or without stretching of the Achilles tendon (Vulpius surgery). A multiple linear regression analysis was performed with backward selection of the following variables: Valenti preoperative classification and the preand postoperative Bordelon, Kite, Gould, Meary and Pitch angles that were measured from the radiographic images of the patients who received arthroereisis. Results: Arthroereisis with synthetic material interposition was satisfactory, with 21 of the feet (91% of cases) showing clinical and radiographic improvement with angle correction and improved degree of deformity based on the Valenti classification. Two cases experienced implant loosening. The Bordelon and Pitch angle variables had a significant effect (p<0.05) on the improvement in degree of deformity correction based on the Valenti classification. Conclusion: Arthroereisis resulted in significant improvements in the patients who were studied, with pronounced clinical improvement and high degrees of satisfaction. Level of evidence IV; Therapeutic Studies; Case Series.
The Triumphant Genealogical Awareness of the Nobility in the Grand Duchy of Lithuania in the 17th and 18th Centuries
Authors: Railaitė-Bardė Agnė 
Published: June 2019

This article attempts to show how the manifestation of ancestors was expressed in the genealogical awareness of the nobility in the Grand Duchy of Lithuania, using publications to mark special occasions in the 17th and 18th centuries, genealogical trees and diagrams. The research seeks to establish what effect the exaltation of various battles had on the genealogical memory of the nobility in the Grand Duchy, bearing in mind the context of its involvement in one of the most famous battles it ever fought. The genealogical sources mentioned were examined in order to ascertain which battles and what memories of the commanders who fought in them were important to the genealogical awareness of the nobility, and why this memory was selective, for some battles and notable heroes from these battles are remembered and glorified, while others are simply forgotten. Memories of which battles were important to the genealogical presentation of certain families, how was it expressed, and in what period were the ancestors who participated in these battles remembered?
The first part of the study presents the memory of ancestors as soldiers, and the ways this memory was expressed. The second part focuses on ancestors who distinguished themselves in specific battles, and which family members who participated in battles are remembered and honoured, in this way distinguishing them from other ancestors.
HIPOCLORITO DE SODIO YÁCIDO HIPOCLOROSO: CAPACIDAD DE DISOLUCIÓN DE TEJIDO ORGÁNICO (ESTUDIOIN-VITRO)
Authors: Loiacono Romina 
Published: June 2019

OBJETIVO: Comparar la capacidad de disolución de tejido orgánico de dos soluciones (NaOCl y HOCl), sometiéndolas a diferentes protocolos de tiempo y temperatura MATERIALES y MÉTODOS: Para el presente estudio se obtuvieron 120 muestras de tejido vacuno ex vivo, el cual fue dividido en 10 grupos de 12 muestras cada uno. Se utilizaron 4 soluciones de NaOCl con concentraciones de: 5.25%, 2.5%, 1% y 0.5% respectivamente y una solución de HOCl al 5%. Las muestras fueron observadas a distintos intervalos de tiempo: 1 minuto, 5 minutos, 15 minutos, 30 minutos, 45 minutos y 60 minutos. Así los datos recogidos de las observaciones se basaron en cambios macroscópicos presentes en la superﬁcie de cada muestra y posteriormentefueronanalizadosestadísticamenteendiferentespruebas. RESULTADOS:Los datos fueron analizados con el programa informático Statistica 7.0. El análisis 1 comparó, en los distintos intervalos de tiempo, la capacidad de disolución de tejido orgánico entre las distintas concentraciones del NaOCl y el HOCl, a los 5 minutos y a los 15 minutos, no arrojaron diferencias signiﬁcativas mientras que 30 a 60 minutos, sí permitieron observar diferencias signiﬁcativas. En la segunda parte del análisis estadístico se comparó, en los distintos intervalos de tiempo, la valoración entre las dos temperaturas probadas 21oC y37 oC, los resultados obtenidos para los tiempos 1 minuto, 45 minutos y 60 minutos, no permiten observar diferencias signiﬁcativas. Para los intervalos de 5 minutos, 15 minutos y 30 minutos, sí se observaron diferencias, siempre a favor de las muestras tratadas a 37oC.
TÉCNICAS ROTATORIA Y CONVENCIONAL PARA PULPECTOMIAS Y SU EFECTO EN EL TIEMPO OPERATORIO Y ANSIEDAD DE PREESCOLARES.
Authors: Manani-Cori Vilma 
Published: June 2019

OBJETIVO: El propósito de este estudio fue comparar dos técnicas de instrumentación para pulpectomías, denominadas rotatoria y convencional,sobre el tiempo operatorio y ansiedad de preescolares. MATERIALES Y MÉTODOS: El estudio fue cuasiexperimental, de corte longitudinal. Se seleccionaron 2 grupos de estudio, con 20 pre escolares cada uno, quienes contaron con consentimiento y asentimiento informado. Para establacer posibles diferencias entre los valores obtenidos, se utilizaron las pruebas T de Student y Chi Cuadrado de Mc Nemar. RESULTADOS: El tiempo operatorio en las pulpectomias de molares deciduos fue de 31,95 min ( 1,54) para la instrumentación rotatoria, y de 48,35 min (2,48) para la instrumencaión convencional. La frecuencia cardíaca de los preescolares varió de 70,65 latidos por minutos (LPM) (3,36); durante la instrumentación rotatoria, a 85,30 ( 3,94); durante la instrumentación convencional. Por otro lado, la saturación de oxígenos delos niños no varió significativamente siendo de 91,55%( 0,89) durante la instrumentación rotatoria y de 91,70%(1,26) durante la instrumentación convencional.CONCLUSIÓN: Las diferencias registradas en relación con el tiempo opereatorio y la ansiedad de preescolares sometidos a dos tipos de técnicas de instrumentación ( rotatoria y convencional), para pulpectomías de molare deciduos, son estadísticamente significactivas ( IC del 95%; p<0,001).
DISTALIZACIÓN DE MOLARES EN MALOCLUSIÓN CLASE II DENTAL CON MECÁNICA DE SLIDING HOOK
Authors: Casasa-Araujo Adan 
Published: June 2019

OBJETIVO. Se valora dos pacientes con vínculos filiales de 9 y 14 años, de sexo femenino, en consulta privada motivo: presencia de retraso en la erupción de dientes permanentes. En la valoración clínica y radiológica muestran, el primer caso, de 9 años, presenta posiciones anómalas de las piezas 11 y 46. Caso dos, de 14 años: anomalías de erupción de pieza 21, ausencia de segundos premolares superior e inferior izquierdo. Ambos casos presentan oclusión Clase I de Angle, resalte de 4mm y sobrepase de 1/3 de la corona. Se utilizó la metodología Demirjian para cuantificar el estadio de mineralización y puntaje de madurez. Por último se discutió posibles atribuciones a esta causa de retención con una revisión bibliográfica
ERUPCIÓN PASIVA ALTERADA: REPORTE DE CASO
Authors: Pinos Ochoa Xavier 
Published: June 2019

La erupción pasiva alterada produce un exceso gingival el cual ocasiona pseudobolsas y compromete la estética del paciente. El tratamiento periodontal debe enfocarse en restablecer la relación normal entre el margen gingival, la cresta ósea alveolar y la unión amelocementaria (CAL). El objetivo de este artículo es presentar el manejo clínico (diagnóstico y plan de tratamiento) de la erupción pasiva alterada.
PSYCHOLOGICAL ASPECTS IN TREATMENT AND CARE FOR NEWBORNS WITH HYPOXIC-ISCHEMIC ENCEPHALOPATHY AT THE ACUTE STAGE OF DISEASE (case report)
Authors: Sirenko T. , Plakhotnaya O. , Ashcheulov O. , Kukuruza A. 
Published: June 2019

the article presents the experience of using medical-psychological aspects of treatment of hypoxic-ischemic encephalopathy in newborns in acute period of the disease. The elements of early influence on the development of the child’s psychomotor activity were used on the basis of modern medical technology of treatment. These elements included sensor stimulation: (vestibular, proprioceptor, tactile), development of motility, hearing and sight perception. The study showed positive changes in neurological symptoms in children, resulting in a reduced duration of the hospital stay.KeyWords: newborn, hypoxic-ischemic encephalopathy, medical-psychological treatment. ПСИХОЛОГІЧНІ АСПЕКТИ ЛІКУВАННЯ ТА ВИХОДЖУВАННЯ НОВОНАРОДЖЕНИХ З ГІПОКСИЧНО-ІШЕМІЧНОЮ ЕНЦЕФАЛОПАТІЄЮ В ГОСТРОМУ ПЕРІОДІСіренко Т.В., Плахотна О.М., Ащеулов О.М., Кукуруза А.В. У статті представлений досвід використання медико-психологічних аспектів лікування гіпоксично-ішемічної енцефалопатії у новонароджених в гострому періоді захворювання. Елементи раннього впливу на розвиток психомоторної активності дитини використовувалися на основі сучасної медичної технології лікування. Ці елементи включали сенсорну стимуляцію: (вестибулярну, пропріоцепторну, тактильну), розвиток моторики, слухове і зорове сприйняття. Дослідження показало позитивні зміни в неврологічних симптомах у дітей, що призвело до скорочення тривалості перебування в стаціонарі. Ключові слова: новонароджений, гіпоксично-ішемічна енцефалопатія, медико-психологічне лікування. ПСИХОЛОГИЧЕСКИЕ АСПЕКТЫ ЛЕЧЕНИЯ И ВЫХАЖИВАНИЯ НОВОРОЖДЕННЫХ С ГИПОКСИЧЕСКИ-ИШЕМИЧЕСКОЙ ЭНЦЕФАЛОПАТИЕЙ В ОСТРОМ ПЕРИОДЕСиренко Т.В., Плахотная О.Н., Ащеулов А.М., Кукуруза А.В. В статье представлен опыт использования медико-психологических аспектов лечения гипоксически-ишемической энцефалопатии у новорожденных в остром периоде заболевания. Элементы раннего влияния на развитие психомоторной активности ребенка использовались на основе современной медицинской технологии лечения. Эти элементы включали сенсорную стимуляцию: (вестибулярную, проприоцепторную, осязательную), развитие моторики, слуховое и зрительное восприятие. Исследование показало положительные изменения в неврологических симптомах у детей, что привело к сокращению продолжительности пребывания в стационаре. Ключевые слова: новорожденный, гипоксически-ишемическая энцефалопатия, медико-психологическое лечение.