bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ БЕЗОПАСНОСТИ ЭКСТРАКТА СУХОГО ИЗ ПОДЗЕМНОЙ ЧАСТИ RHAPONTICUM UNIFLORUM
Authors: Я.Г. Разуваева , А.А. Торопова , Е.А. Убеева , В.Г. Банзаракшеев , В.В. Аюшева 
Published: November 2024

В экспериментах на белых крысах линии Wistar исследовали хроническую токсичность и возможное местнораздражающее и мутагенное действие экстракта сухого из корневищ с корнями Rhaponticum uniflorum L. DC. Влияние экстракта сухого R. uniflorum на морфофункциональное состояние внутренних органов оценивали при его трехмесячном введении (per os) в дозах 100 и 500 мг/кг. Возможное местонораздражающее и мутагенное действие исследуемого средства определяли при его однократном введении в дозах 100 и 100 мг/кг. Установлено, что длительное введение экстракта сухого R. uniflorum не оказывает отрицательного влияния на морфофункциональное состояние центральной нервной, сердечно-сосудистой и мочевыделительной систем, органов желудочно-кишечного тракта, состояние обмена веществ, показатели периферической крови и системы гемостаза лабораторных животных. Исследуемое средство не вызывает местнораздражающего и мутагенного действия.
The purpose of this work is to determine chronic toxicity, as well as the possible local irritating and mutagenic effect of Rhaponticum uniflorum L. DC. root extract. The studies were performed on white Wistar rats. The effect of R. uniflorum extract on the morphofunctional state of internal organs was assessed after its three-month administration (per os) at doses of 100 and 500 mg/kg. The possible locally irritating and mutagenic effect of the investigational agent was determined with its single administration at doses of 100 and 1000 mg/kg. It was found that long-term administration of R. uniflorum extract does not have a negative effect on the morphofunctional state of the central nervous, cardiovascular and urinary systems, organs of the gastrointestinal tract, the state of metabolism, indicators of peripheral blood and the hemostasis system of laboratory animals. A single administration of the test agent in doses of 100 and 1000 mg/kg does not have a local irritating effect on the mucous membrane of the digestive tract and does not exhibit a mutagenic effect.
ПОДХОДЫ К СТАНДАРТИЗАЦИИ ТРАВЫ ТОПИНАМБУРА
Authors: О.Л. Сайбель , Е.А. Коняева , А.И. Радимич , Т.Д. Даргаева 
Published: November 2024

Приведены результаты изучения нового вида лекарственного растительного сырья – топинамбура травы, предложенной в качестве сырья для производства лекарственных средств. Установлены критерии подлинности (морфологические и анатомо-диагностические признаки, тонкослойная хроматография) и показатели качества (номенклатура числовых показателей) данного вида сырья. Разработана методика количественного определения содержания действующих веществ. Предложенные критерии качества включены в проект фармакопейной статьи.
The results of the study of a new type of medicinal plant raw material - Jerusalem artichoke grass, proposed as a raw material for the production of medicines. The criteria of authenticity (morphological and anatomical diagnostic signs, thin-layer chromatography) and quality (nomenclature of numerical indicators) of this type of raw materials are established. A method of quantitative determination of the content of active substances has been developed. The proposed quality criteria are included in the draft pharmacopoeial article.
ТЕХНОЛОГИЧЕСКИЕ ПОДХОДЫ СОЗДАНИЯ ТВЕРДЫХ ЛЕКАРСТВЕННЫХ ФОРМ С СУБСТАНЦИЯМИ РАСТИТЕЛЬНОГО ПРОИСХОЖДЕНИЯ
Authors: Т.В. Качалина , Н.А. Малышева , О.А. Семкина 
Published: November 2024

В работе представлены технологические аспекты разработки твердых лекарственных форм с субстанциями растительного происхождения с учетом их физико-химических свойств. Показана закономерность выбора лекарственной формы, вспомогательных веществ и параметров технологического процесса при получении таблеток и капсул на основе сухих экстрактов на всех этапах их разработки. Цель исследования - определение технологических подходов создания таблеток и капсул с сухими экстрактами растительного происхождения. Материалы: сухие экстракты растительного происхождения винограда культурного листьев красных, зюзника европейского травы, лапчатки белой корневищ и корней, сабельника болотного корневищ с корнями. Методы исследования позволили определить физико-химические и технологические характеристики субстанций, таблеточных композиций и капсульных масс на их основе. Изучение технологических параметров и физико-химических свойств субстанций растительного происхождения позволило осуществить рациональный выбор лекарственной формы (таблеток и капсул), а также вспомогательных веществ и их соотношения, разработать технологию получения лекарственного препарата.
The paper presents the technological and physical-chemical aspects of the development of solid dosage forms of phytopreparations, based on the characteristics (analysis results) substances of plant origin. The regularity of the choice of excipients, the need to determine their characteristics and parameters of the technological process when obtaining tablets and capsules based on dry extracts at all stages of their development is shown.
ПРИМЕНЕНИЕ УРАВНЕНИЙ ХЕККЕЛЯ И КАВАКИТЫ В ТЕХНОЛОГИИ ТАБЛЕТОК ГСБ-106
Authors: В.В. Буева , Е.В. Блынская , К.В. Алексеев , С.В. Тишков , С.В. Минаев 
Published: November 2024

Проведены исследования механизмов, преобладающих в процессе прессования, с применением уравнений Хеккеля и Кавакиты, в результате которого описан процесс прессования таблеточной смеси и получены значения давлений: оптимального давления прессования и давления, необходимого для уменьшения материала в объеме на 50%.
Studies of compacting mechanisms were undertaken using the Heckel and Kawakita equations, which describes the process of tablet mass compacting. As a result the yield pressure and the pressure required to reduce the powder bed by 50% were obtained.
НОВЫЕ ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СУХОГО ЭКСТРАКТА КРАСНЫХ ЛИСТЬЕВ ВИНОГРАДА КУЛЬТУРНОГО (VITIS VINIFERA L.)
Authors: С.В. Лемясева , Л.В. Крепкова , А.Н. Бабенко , М.В. Боровкова , О.С. Кузина 
Published: November 2024

В статье представлены результаты экспериментального изучения гиполипидемической активности сухого экстракта из красных листьев винограда культурного (Vitis vinifera L.). Показано, что исследуемый экстракт в дозе 500 мг/кг при введении в желудок нормолипидным крысам и с экспериментально воспроизведенной твиновой и алиментарной гиперлипидемией снижал содержание липидов и глюкозы в сыворотке крови подопытных животных. Полученные результаты позволяют рекомендовать его в составе комплексной терапии метаболического синдрома.
The results of experimental study of hypolipidemic activity of dry extract from red leaves of cultivated grapes (Vitis vinifera L.) are presented in the article. It was shown that the studied extract at a dose of 500 mg/kg when injected into the stomach of normolipid rats and with experimentally reproduced Twin and alimentary hyperlipidemia, reduced the lipid and glucose content in the blood serum of experimental animals. The obtained results allow to recommend it as a part of complex therapy of metabolic syndrome.
ПЕРСПЕКТИВЫ ПОЛУЧЕНИЯ И ИССЛЕДОВАНИЯ КЛЕТОЧНЫХ КУЛЬТУР ВИДОВ РОДА АРАЛИЯ(ARALIA SSP.)
Authors: Д.А. Некрасова , М.Н. Повыдыш , Н.С. Пивоварова , М.Ю. Гончаров 
Published: November 2024

В данной статье обобщена информация о характеристике, охранном статусе, способах введения в культуру in vitro представителей рода Aralia L., описаны накапливаемые культурами клеток вторичные метаболиты
This article summarizes information about the characteristics, conservation status, methods of introducing into culture in vitro plants of the genus Aralia L., describes the secondary metabolites accumulated by cell cultures.
APROXIMACIÓN PROTEÓMICA DE FOSFOLIPASAS A2 (PLA2 Y HOMOLOGA K49) A PARTIR DEL VENENO DE BOTHROPS BARNETTI Y SU BIOPROSPECCIÓN EN ESTUDIOS PROINFLAMATORIOS POR ANÁLISIS BIOINFORMÁTICO. AREQUIPA, 2019
Authors: León Puma Nicolás Hipólito , León Ramos Yubica Allisón 
Published: November 2024

Se ha logrado purificar y caracterizar bioquímicamente una fosfolipasa A2 y una homóloga K49 a partir del veneno total de Bothrops barnetti de procedencia peruana.

En la purificación de ambas proteínas la fosfolipasa A2 y la fosfolipasa A2 homóloga K49, se ha empleado un paso cromatográfico a través de una cromatografía convencional de interacción hidrofóbica, donde se obtuvo nueve fracciones: denominadas del 1 al 9 respectivamente. La fracción 5 fue caracterizada bioquímicamente como una fosfolipasa A2 al medir su actividad enzimática frente a un sustrato cromogénico altamente específico como es el 4-nitro-3 (octanoiloxi) acido benzoico a pH de 7,9. De otro lado se caracterizó estructuralmente una fosfolipasa A₂ homóloga K49 desprovista completamente de actividad catalítica.

La electroforesis bidimensional (2D), reveló el carácter de 5 fracciones denominadas como P101, P102, P103, P104 y P105 respectivamente por poseer una masa aproximada de 14 kDa y un pI en alrededor de 7.6 a 8.5 lo que evidenciaría la presencia de fosfolipasas A2 y/o homólogas K49, a partir del veneno total desde una perspectiva de aproximación proteómica.

La secuencia de aminoácidos fue determinada vía espectrometría de masas ESI-MS/MS y se caracterizaron dos toxinas una fosfolipasa A2 y una fosfolipasa A₂ homóloga K49. Los estudios de homología secuencial utilizando las bases de datos desde su identificador con el programa MASCOT y la base de datos del Swiss prot, nos permitió confirmar la deducción de la cadena polipeptídica tratándose de estas 2 proteínas estudiadas.

Desde la perspectiva farmacológica se exploraron las actividades edematogénicas en el experimento edema de pata, en el que quedó claramente evidenciado su efecto proinflamatorio de ambas toxinas, donde la actividad catalítica podría ser o no importante. Hecho que fue confirmado con el dosaje
de los niveles de IL-6 los cuales mostraron ser tiempo-dependientes como un efecto local.
DECORONACIÓN- UN PROCEDIMIENTO PARA MANTENER EL REBORDE ALVEOLAR EN DIENTES CON REABSORCIONES POR SUSTITUCIÓN (ANQUILOSIS).
Authors: Monteiro Bramante Clovis , Gallegos Misad Pedro Pablo , Silva Bramante Alexandre , Khouri Diep Eduardo , Gallegos Vargas Herbert Mario , Quiroz Huerta Carlos Alberto 
Published: November 2024

Decoronación es un procedimiento en el cual la corona del diente comprometido es removida, manteniendo la raíz. Dientes con reabsorción por sustitución pueden provocar, además de la reabsorción de la raíz, la pérdida del hueso alveolar, dificultando después la sustitución protética del diente.
Este procedimiento tiene como objetivo mantener la altura y ancho del hueso alveolar.

Este caso clínico describe la técnica de la Decoronación y la presentación de un caso clínico.

El Control clínico y radiográfico después de 1 año, muestra la mantención del nivel del reborde alveolar.
DIAGNÓSTICO TEMPRANO DE AMBLIOPÍA
Authors: Noel Córdova Edgard 
Published: November 2024

Propósito
Discutir el uso del examen visual con y sin instrumentos para detectar ambliopía y sus factores de riesgo, y resumir la importancia del examen visual entre los 4-5 años.

Método
La experiencia del autor fue complementada por una revisión e interpretación de la literatura médica pertinente.

Resultados
La ambliopía es una enfermedad asintomática y el tratamiento es mucho más eficaz si se lleva a cabo a una edad más temprana. El diagnóstico de ambliopía tiene mejores resultados cuando se realiza un examen visual completo entre los 3-5 años que el examen visual realizado con instrumentos en niños menores de 3 años; La US Preventative Services Task Force (USPSTF) recomienda el examen visual al menos una vez en niños de 3-5 años para detectar ambliopía o sus factores de riesgo. La detección temprana de ambliopía permite que un tratamiento más efectivo pueda ser iniciado.

Conclusiones
La ambliopía es una causa reversible de pérdida visual en los niños. Si bien los programas de examen visual con instrumentos han sido ampliamente estudiados en niños menores de 3 años; se recomienda el examen visual en niños entre los 3-5 años.
Efficacy of Rifaximin and Probiotics in the Treatment of Small Intestinal Bacterial Overgrowth When Used Concomitantly or Sequentially
Authors: Hammour Adnan , Abu-Hammour Mohamad-Noor , Al-Sheyyab Ahmad , Dajani Asad 
Published: November 2024

Background: With the prevalence of small intestinal bacterial overgrowth (SIBO) on the rise, treatment has become of paramount importance for patients suffering from this disease. Antibiotics used to treat SIBO include rifaximin, ciprofloxacin, metronidazole, and neomycin. Probiotics reinforce the small intestine's internal microbiota and help cure many diseases.

Aim: In this study, we aimed to evaluate the efficacy of rifaximin together with a multi-strain probiotic in patients with SIBO. In a multi-center open-labeled prospective study, recruited patients were randomized into two groups treated with rifaximin as a base and probiotics that varied in the timing of initiation (concomitantly; group A or sequentially; group B) for treating the clinical manifestations of the disease. The primary endpoint evaluated the clinical response to treatment, and the secondary endpoint evaluated the eradication rates.

Results: Eradication rates revealed that 69.8% of the patients in group A and 74.8% of the patients in group B were successfully treated and returned with negative lactulose hydrogen breath test results. Clinical response rates were divided into partial and complete responders; partial responders were reported in 23.3% and 26.6% of patients in groups A and B, respectively, and complete responders were reported in 62.7% and 59.5% of patients in groups A and B, respectively. Overall, partial or complete responders' combined rate comprised 86% and 86.2% in groups A and B, respectively. There were no reported side effects by patients treated with rifaximin and the multi-strain probiotic for both protocols.

Conclusion: The addition of probiotics, both concomitantly or sequentially, to the treatment regimen acts synergistically with rifaximin to improve outcomes. According to our study, there were no statistical differences between the two regimens. In conclusion, the extension of probiotics in the sequential regimen provided a more prolonged clinical response rate.
A Retrospective Study of Glomerulonephritis Patterns Among Jordanian Children
Authors: Sheyyab Ahmed , Hamed Radi 
Published: November 2024

Background and Aim: Glomerular diseases affecting pediatric patients differ from conditions encountered in adults. Additionally, the pattern of glomerular disease varies in different regions of the world. In the Mediterranean region, data on glomerular diseases in children patients remain sparse. Therefore, we conducted a study to assess glomerulonephritis disease patterns at our institute and assess for recent incidence trends.

Methods: A retrospective study conducted at a university affiliated tertiary hospital located in the capital city of Amman. We included native kidney biopsy reports of patients who fulfilled our age criterion of < 15 years old.

Results: Our study showed a total of 178 kidney biopsies, of which 71 patient fulfilled our inclusion criteria. The average age of studied patients was 7.6 ± 4.1 years. Our study had more males compared to females, 56% and 44%, respectively. In nephritic syndrome, IgA nephropathy was the most common cause (13%), which was followed by Post-Infectious glomerulonephritis (8%). In children with nephrotic syndrome, MCD was exceedingly more common in male children when compared to females, 14 versus 8 patients, respectively. While FSGS was more common among females compared to males, 5 versus 2 patients, respectively.
A Comprehensive Evaluation of the Preanalytical Phase in Laboratory Medicine, Nephrology, Emergency Specialties, Visceral Surgery, Pediatrics, Internal Medicine and Neonatology Hospital Departments: In-Depth Insights derived from an analysis of practices at a Medical University Centre in Morocco
Authors: Rahhab Oussama , Sebbar El houcine , Choukri Mohammed 
Published: November 2024

Background and Aims: The precision of biological examination results hinges on meticulous preparatory measures before analysis, known as the pre-analytical phase. This phase contributes significantly to error rates (48-68%). Our study assessed the pre-analytical phase in seven hospital departments at Mohammed VI University Hospital. The objective was to address key causes of pre-analytical nonconformities.

Materials and Methods: During this investigation, we observed 331 samples from various departments: Central Laboratory, Nephrology, Internal Medicine, Visceral Surgery, Emergency Specialties, Paediatrics, and Neonatology. Our evaluation identified 4945 instances of pre-analytical nonconformities. These cases encompassed issues with the prescription sheet (501), patient preparation (848), equipment preparation (295), sampling process (1957), waste management (323), and sample transfer (422).

Results: Our analysis highlighted a multitude of pre-analytical nonconformities within the surveyed hospital departments. These discrepancies illuminated the critical areas where corrective and preventive measures were imperative to adhere to the standards set by the International Standard ISO15189 and to optimize patient care.

Conclusions: The findings from this study underscore the paramount importance of the pre-analytical phase in ensuring accurate biological examination results. By implementing a series of targeted actions in the concerned hospital departments, we addressed the identified nonconformities. These actions encompassed ongoing education, staff awareness and support, regular audits, provision of technical resources such as manuals and sample catalogues, as well as the utilization of appropriate equipment for sample collection and transportation. Continuous learning remains essential, encompassing proper sampling techniques, packaging and transportation requisites, as well as procedures for identifying and rectifying biological sample nonconformities
Acceptance of Cosmetic Surgery: Client Perspectives
Authors: Ibrahim Radhwan , Ibrahim Dunia 
Published: November 2024

Background: In the past decade, there has been an increase in the number of cosmetic procedures performed globally. About one-third of individuals who undergo cosmetic procedures are under the age of 35 years. Several factors can influence acceptance of cosmetic surgery including media, religion, and individual factors among others.

Objective: The objective of this current study is to investigate the motivations behind individuals choosing to undergo cosmetic surgery.

Material and methods: This study was a cross-sectional single-center, conducted to assess the attitudes and acceptance of cosmetic surgery among attendees at Cosmetic and beauty centres in the city of Mosul, Iraq between September -November of 2022. All patients at the plastic surgery clinics were given a questionnaire that they were instructed to fill out in their own time. The likelihood of having cosmetic surgery scale, the Rosenberg self-esteem scale, the life happiness scale, and the physical attractiveness scale were used to measure the correlation between these variables and other factors. With a p-value of less than 0.05, the results might be considered reliable. Pearson's correlation coefficient was used for the investigation of correlations (r).

Results: The mean age was 31.47 years, the standard deviation was 2.8, the range of ages was 15-52 years, and the median age was 29.89 years. There was an insignificant weak positive connection between participants' self-esteem and their acceptance of cosmetic surgery (r=0.052)

Conclusion: Lower levels of self-esteem and life satisfaction, greater exposure to cosmetic surgery in the media (especially television), increased time spent in front of the TV, and religious affiliation were all found to be significant predictors of future use of cosmetic surgery in the current study.
The Incidence of Psychosis Among Parkinson's Disease Patients and Associated Factors: A Meta-Analysis
Authors: Alsharaeh Tala , Salahat Ahmed-Jordan , Alhajahjeh Abdulrahman , Khudirat Mohammad , Alashoor Ali , Shuriquie Leith , Alquabeh Batool , AlRyalat Saif Aldeen 
Published: November 2024

Introduction: Parkinson's-induced psychosis is rather prevalent, and it has continuously been linked to poor outcomes. Therefore, detecting this presentation early on, can enhance the quality of life of Parkinson’s disease patients and is therefore a clinical and societal necessity. This systematic review and meta-analysis aimed to estimate the pooled incidence of induced psychosis or psychosis associated with neurodegeneration in Parkinson’s disease.

Materials and Methods: PubMed, Scopus, and Cochrane Library were searched to identify studies reporting the prevalence of psychosis in Parkinson’s disease patients. A random-effect meta-analysis was used to pool data from the included studies. The objectives, inclusion criteria, and methods of analysis for this review were specified in advance and documented in a priori protocol (PROSPERO reg. num. CRD42022318920).

Results: Twenty studies including 5,123 Parkinson’s disease patients which explored the incidence of presenting symptoms of psychosis in Parkinson’s disease patients were included in the final analysis. The meta-analysis showed that the incidence of psychosis among Parkinson’s disease patients was 35%. A subgroup analysis was performed which showed that disease duration could explain the statistical heterogeneity in this meta-analysis.

Conclusion: This systematic review and meta-analysis revealed that psychotic disorders are highly prevalent among Parkinson’s disease patients, indicating an urgent need for further studies to help develop better mechanisms of prevention, detection, and treatment of those disorders among Parkinson’s disease patients in an effort to improve their quality of life.
Królestwo Chosŏn i jego mieszkańcy na trasie podróży fregaty „Pallada” (1852–1854) w relacji Iwana Gonczarowa w świetle wczesnych kontaktów rosyjsko-koreańskich
Authors: Wadas Andrzej 
Published: November 2024

W 1854 roku rosyjska załoga fregaty „Pallada” wielokrotnie zetknęła się z mieszkańcami Królestwa Chosŏn na wyspie Kŏmundo oraz w kilku miejscach podczas rejsu wzdłuż całego wschodniego wybrzeża kraju. Było to pierwsze i zarazem najważniejsze rosyjsko-koreańskie spotkanie na trasie rejsów morskich, jako że wcześniejsze kontakty między przedstawicielami obydwu cywilizacji miały miejsce na trasach lądowych, podczas walk o Albazin oraz w trakcie misji prawosławnej w Pekinie. Celem artykułu jest przeanalizowanie tych spotkań opisanych w relacji Iwana Gonczarowa, zawartej w dziele Fregata Pallada w szerszym kontekście politycznym i kulturowym, uwzględniającym zarówno lądową historię kontaktów rosyjsko-koreańskich w XVII i XVIII wieku, jak również morską rywalizację mocarstw zachodnich w Azji Północno-Wschodniej w dobie wojen opiumowych, powstania tajpingów oraz wojny krymskiej. O znaczeniu tej wymiany świadczy również fakt, że wzmianki o niej zostały uwiecznione w źródłach koreańskich, w szczególności w „Dziennikach Sekretariatu Królewskiego” (Sŭngjŏngwŏn ilgi) oraz „Rocznikach Dynastii Chosŏn” (Chosŏn wangjo sillok).