bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fuzzy clustering recognition algorithm of medical image with multi‐resolution feature
Authors: Bo Wang , Ying Wang , Lijie Cui 
Published: September 2018

SummaryMost current medical images are collected in the presence of interference by ignored interferences such as illumination, occlusion, etc. The recognition rate is low for multi‐resolution images in the case of color distortion. Therefore, a novel fuzzy clustering recognition algorithm of multi‐resolution medical image was proposed in this paper. First, medical images were analyzed from both acquisition time, shooting angle, resolution, natural light measurement, and background. Secondly, in order to avoid partial occlusion, region was recalculated by correlation between Fourier and Merlin transform. Moreover, Euclidean distance between samples were identified by standardized eigenvalues, where smallest distance obtained maximum degree of membership. Experiment results showed that the proposed method had higher recognition rate (accuracy 90.46% and sensitiveness 97.89%) and stronger anti‐interference than current methods.
Polyanionic Polydentate Europium Complexes as Ultrabright One‐ or Two‐photon Bioprobes
Authors: Sund Henri , Liao Yuan‐Yuan , Andraud Chantal , Duperray Alain , Grichine Alexei , Le Guennic Boris , Riobé François , Takalo Harri , Maury Olivier 
Published: September 2018

AbstractA family of europium (III) complexes based on a polydentate ligand functionalized by charge‐transfer antennae presents remarkable one‐ and two‐photon photophysical proper‐ties in water or buffer. A detailed analysis of their emission properties suggests that the wrapping of the ligand around the central rare‐earth ion results in an overall Cs symmetry in agreement with the theoretical simulation and that about 65–70 % of the emission intensity is concentrated in the hypersensitive 5D0→7F2 transition at 615 nm. Their brightness is excellent, in the range of the best lanthanide bioprobes making them very attractive for bio‐imaging experiments.
Iridium α‐Carboxyimine Complexes Hyperpolarized with para‐Hydrogen Exist in Nuclear Singlet States before Conversion into Iridium Carbonates
Authors: Tickner Ben. J. , Iali Wissam , Roy Soumya S. , Whitwood Adrian C. , Duckett Simon B. 
Published: September 2018

AbstractThe formation and hyperpolarization of an [Ir(H)2(amine)(IMes)(η2‐imine)]Cl complex that can be created in a hyperpolarized nuclear singlet state is reported. These complexes are formed when an equilibrium mixture of pyruvate, amine (benzylamine or phenylethylamine), and the corresponding imine condensation product, react with preformed [Ir(H)2(amine)3(IMes)]Cl. These iridium α‐carboxyimine complexes exist as two regioisomers differentiated by the position of amine. When examined with para‐hydrogen the hydride resonances of the isomer with amine trans to hydride become strongly hyperpolarized. The initial hydride singlet states readily transfer to the corresponding 13C2 state in the labelled imine and exhibit magnetic state lifetimes of up to 11 seconds. Their 13C signals have been detected with up to 420 fold signal gains at 9.4 T. On a longer timescale, and in the absence of H2, further reaction leads to the formation of neutral carbonate containing [Ir(amine)(η2‐CO3)(IMes)(η2‐imine)]. Complexes are characterized by, IR, MS, NMR and X‐ray diffraction.
LLC resonant converter utilizing a step‐gap transformer structure for holdup time improvement
Authors: Lin Jing‐Yuan , Lee Sih‐Yi , Yueh Hsuan‐Yu 
Published: September 2018

SummaryThis letter presents a current‐controlled variable magnetizing inductance of transformer for further improving the holdup time on half‐bridge LLC converter. When the input voltage is failed, the magnetizing inductance of transformer can be decreased sharply; therefore, the LLC converter holdup time can be improved without adding additional auxiliary circuit. The mathematic model between magnetizing inductance and step‐gap structure of transformer is proposed, and the benefit effects using this step‐gap structure of transformer have been verified in this letter. Finally, a 180‐W, LLC converter utilizing step‐gap structure of transformer has been achieved, and detailed analysis and design of the proposed step‐gap structure are described.
Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis
Authors: Niersmann Corinna , Hauck Stefanie M. , Kannenberg Julia M. , Röhrig Karin , von Toerne Christine , Roden Michael , Herder Christian , Carstensen‐Kirberg Maren 
Published: September 2018

AbstractAimsExperimental and epidemiological studies reported controversial data on the role of omentin in type 2 diabetes and cardiovascular diseases. This study aimed to characterise the impact of omentin on the secretome of human adipocytes to analyse the enrichment of these proteins in metabolic and cellular signalling pathways underlying its physiological function.Material/methodsDifferentiated primary human adipocytes were treated without or with 500 or 2000 ng/mL omentin for 24 hours. The secretome was analysed by liquid chromatography coupled tandem‐mass spectrometry. Differences in protein secretion between untreated and omentin‐treated adipocytes were compared using a paired t‐test. Other potential upstream regulators and the overrepresentation in canonical pathways of omentin‐stimulated proteins were analysed using Ingenuity Pathway Analysis.ResultsThe supernatant of adipocytes contained 3493 proteins, of which 140 were differentially secreted by both concentrations of omentin compared with untreated adipocytes. Among the most strongly increased proteins, tumour necrosis factor‐inducible gene 6 protein (TNFAIP6) was increased by 140‐fold in the supernatant. Omentin‐regulated proteins were overrepresented in seven canonical pathways including eukaryotic initiation factor 2 signalling, complement system, and inhibition of matrix metalloproteases. We further identified 25 other potential upstream activators of omentin‐regulated proteins, mainly pro‐inflammatory cytokines and transcription regulators including NFκB.ConclusionsIn differentiated human adipocytes, the release of the anti‐inflammatory TNFAIP6 might be part of a counterregulatory response to the pro‐inflammatory action of omentin. Omentin‐regulated proteins were overrepresented in pathways indicating cellular stress, a pro‐inflammatory environment and a crosstalk with other organs. Other potential activators of omentin‐regulated proteins point towards a central role of NFκB activation in the omentin‐induced secretory process.
The effect of collector type on the physical, chemical, and biological properties of polycaprolactone/gelatin/nano‐hydroxyapatite electrospun scaffold
Authors: Sattary Mansoureh , Rafienia Mohammad , Khorasani Mohammad Taghi , Salehi Hossein 
Published: September 2018

AbstractElectrospinning is considered a powerful method for the production of fibers in the nanoscale size. Small pore size results in poor cell infiltration, cell migration inhibition into scaffold pores and low oxygen diffusion. Electrospun polycaprolactone/gelatin/nano‐hydroxyapatite (PCL/Gel/nHA) scaffolds were deposited into two types of fiber collectors (novel rotating disc and plate) to study fiber morphology, chemical, mechanical, hydrophilic, and biodegradation properties between each other. The proliferation and differentiation of MG‐63 cells into the bone phenotype were determined using MTT method, alizarin red staining and alkaline phosphatase (ALP) activity. The rates for disc rotation were 50 and 100 rpm. The pore size measurement results indicated that the fibers produced by the disc rotation collector with speed rate 50 rpm have larger pores as compared to fibers produced by disc rotation at 100 rpm and flat plate collectors. A randomly structure with controlled pore size (38.65 ±0.33 μm) and lower fiber density, as compared to fibers collected by disc rotation with speed rate 100 rpm and flat plate collectors, was obtained. Fibers collected on the rotating disc with speed rate 50 rpm, were more hydrophilic due to larger pore size and therefore, faster infiltration of water into the scaffold and the rate of degradation was higher. These results demonstrate that PCL/Gel/nHA scaffolds made through a rotating disc collector at 50 rpm are more feasible to be used in bone tissue engineering applications due to appropriate pore size and increased adhesion and proliferation of cells, ALP activity and mineral deposits. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 933–950, 2019.
Fitting psychotherapy to patient coping style: A meta‐analysis
Authors: Beutler Larry E. , Kimpara Satoko , Edwards Christopher J. , Miller Kimberley D. 
Published: September 2018

AbstractOver the course of 60 years of research, several personality traits have emerged as potential predictors of differential change in psychotherapy. Among them is the patient's coping style (CS), commonly distinguished between those who deal with change by looking inwardly (internalization) and those who deal with it outwardly (externalization). This study provides definitions of CSs, clinical examples, and frequent measures. We update a 2011 meta‐analytic review that revealed a consistent interaction between CSs and treatment focus—symptom focus versus insight focus. The current meta‐analysis of 18 studies revealed a medium to large effect (d = 0.60) and suggested that a symptom focus proves more effective for externalizing patient whereas an insight focus is generally more effective for internalizers. The article concludes with limitations of the research, diversity considerations, and therapeutic practices based on the meta‐analytic results.
Evaluation of Intra‐ and Interscanner Reliability of MRI Protocols for Spinal Cord Gray Matter and Total Cross‐Sectional Area Measurements
Authors: Papinutto Nico , Henry Roland G. 
Published: September 2018

BackgroundIn vivo quantification of spinal cord atrophy in neurological diseases using MRI has attracted increasing attention.PurposeTo compare across different platforms the most promising imaging techniques to assess human spinal cord atrophy.Study TypeTest/retest multiscanner study.SubjectsTwelve healthy volunteers.Field Strength/SequenceThree different 3T scanner platforms (Siemens, Philips, and GE) / optimized phase sensitive inversion recovery (PSIR), T1‐weighted (T1‐w), and T2*‐weighted (T2*‐w) protocols.AssessmentOn all images acquired, two operators assessed contrast‐to‐noise ratio (CNR) between gray matter (GM) and white matter (WM), and between WM and cerebrospinal fluid (CSF); one experienced operator measured total cross‐sectional area (TCA) and GM area using JIM and the Spinal Cord Toolbox (SCT).Statistical TestsCoefficient of variation (COV); intraclass correlation coefficient (ICC); mixed effect models; analysis of variance (t‐tests).ResultsFor all the scanners, GM/WM CNR was higher for PSIR than T2*‐w (P< 0.0001) and WM/CSF CNR for T1‐w was the highest (P< 0.0001). For TCA, using JIM, median COVs were smaller than 1.5% and ICC >0.95, while using SCT, median COVs were in the range 2.2–2.75% and ICC 0.79–0.95. For GM, despite some failures of the automatic segmentation, median COVs using SCT on T2*‐w were smaller than using JIM manual PSIR segmentations. In the mixed effect models, the subject was always the main contributor to the variance of area measurements and scanner often contributed to TCA variance (P< 0.05). Using JIM, TCA measurements on T2*‐w were different than on PSIR (P = 0.0021) and T1‐w (P = 0.0018), while using SCT, no notable differences were found between T1‐w and T2*‐w (P = 0.18). JIM and SCT‐derived TCA were not different on T1‐w (P = 0.66), while they were different for T2*‐w (P< 0.0001). GM area derived using SCT/T2*‐w versus JIM/PSIR were different (P< 0.0001).Data ConclusionThe present work sets reference values for the magnitude of the contribution of different effects to cord area measurement intra‐ and interscanner variability.Level of Evidence: 1Technical Efficacy: Stage 4J. Magn. Reson. Imaging 2019;49:1078–1090.
Pectoralis major radiation recall
Authors: Hack Emma , Thachil Thanuja , Karanth Narayan 
Published: September 2018

AbstractRadiation recall is an uncommon phenomenon describing an acute localised inflammatory toxicity affecting tissue previously exposed to radiotherapy. It is precipitated by administration of certain medications, including chemotherapy. We describe a case involving a 50‐year‐old Aboriginal male smoker from a remote community in Northern Australia who underwent treatment for stage IV non‐small cell lung cancer with localised radiotherapy to the primary right upper lung lobe tumour. This was followed by a course of gemcitabine, which was ceased prematurely after four cycles when he presented with radiation recall to his right pectoralis major. Our case description is complemented with a brief review of current literature regarding our case and gemcitabine‐related radiation recall. This was in the context of concurrent musculoskeletal strain, an as‐yet unreported association with radiation recall. His condition settled with steroid administration and discontinuation of gemcitabine.
Impact of electrophysiological and pharmacological noninducibility following pulmonary vein isolation in patients with paroxysmal and persistent atrial fibrillation
Authors: Otsuka Takayuki , Sagara Koichi , Arita Takuto , Yagi Naoharu , Suzuki Shinya , Ikeda Takanori , Yamashita Takeshi 
Published: September 2018

AbstractBackgroundTwo methods for testing inducibility of atrial fibrillation (AF)—atrial pacing and isoproterenol infusion—have been proposed to determine the endpoint of catheter ablation. However, the utility of the combination for testing electrophysiological inducibility (EPI) and pharmacological inducibility (PHI) is unclear.MethodsAfter pulmonary vein isolation (PVI), inducibility of atrial tachyarrhythmia was assessed with the dual methods in 291 consecutive patients with AF (65% paroxysmal) undergoing initial catheter ablation.ResultsThe incidence of EPI was significantly higher in patients with persistent AF than paroxysmal AF (32.0% vs 11.7%, respectively, P < .001). The incidence of PHI was not significantly different between the two groups (25.2% vs 26.1%, respectively, P = .87). There was no significant difference in AF recurrence according to inducibility in paroxysmal AF. In persistent AF, however, patients achieving neither EPI nor PHI under PVI‐only strategy had significantly lower rates of AF recurrence than those achieving either EPI or PHI and consequently requiring additional ablation for inducible atrial tachyarrhythmia (68.5% vs 49.0%, respectively; log‐rank test, P = .022). In persistent AF, multivariate Cox regression analysis showed that achieving neither EPI nor PHI was a negative independent predictor of AF recurrence (HR 0.492, 95% CI 0.254‐0.916, P = .026).ConclusionsAchieving neither EPI nor PHI following PVI was associated with favorable outcome in patients with persistent AF. The combination of tests may discriminate patients responsive to the PVI‐only strategy. Further selective approaches are necessary to improve outcome for inducible atrial tachyarrhythmia in patients with persistent AF.
Monitoring of cefepime in urine by micellar electrokinetic capillary chromatography with ultraviolet detection and liquid chromatography coupled to mass spectrometry
Authors: Kummer Mirjam , Šestáková Nela , Theurillat Regula , Huynh‐Do Uyen , Endimiani Andrea , Sendi Parham , Thormann Wolfgang 
Published: September 2018

AbstractCefepime monitoring in urine by micellar electrokinetic capillary chromatography with UV detection and liquid chromatography coupled to mass spectrometry via electrospray ionization is described. For micellar electrokinetic capillary chromatography, sample preparation comprised urine dilution and dodecyl‐sulfate protein precipitation at pH 4.5, whereas diluted urines were analyzed in the other assay. Both approaches provided suitable conditions for cefepime analysis in urines of healthy volunteers that were spiked with cefepime. Cefepime monitoring by micellar electrokinetic capillary chromatography in samples from patients taking multiple drugs were prone to interferences, whereas liquid chromatography coupled to mass spectrometry provided clean chromatograms and thus selective detection of cefepime in all samples. The latter assay was used to measure urinary cefepime in a prospective pilot study and to assess cefepime stability in urines at 25, 4, −20 and −70°C. The data suggest that urinary cefepime is stable for at least 72 h at all tested temperatures.
Estimating avian road mortality when only a single observer is available
Authors: Durkin Maureen M. , Cohen Jonathan B. 
Published: September 2018

ABSTRACTGulf Islands National Seashore in Florida, USA, hosts breeding populations of migratory beach‐nesting birds, along with other avian species. It consists of 2 barrier islands with a public paved road that runs through the center. For the past decade, bird carcasses were observed opportunistically along the roadway, and this mortality sparked interest among wildlife managers about population‐level effects on species of conservation concern. Accurately estimating wildlife mortality from carcass counts requires correcting negative bias due to imperfect detection and scavenging between surveys. We had only 1 observer available to perform road surveys, leading to a carcass detection rate of 1.0 after discovery, and a persistence rate that was only estimable after discovery. We therefore employed a robust design version of a time‐of‐detection model to estimate detection and persistence rates. We used a post hoc derivation of the superpopulation size for carcasses, which is an estimate of the total number of carcasses that were ever present on the road for any period of time. Each primary survey consisted of 2 passes on the road within 4 hours. Probability of detection for 2 passes was near 100%. We counted 77 avian carcasses between 22 May and 4 July 2013 and estimated that this represented 106.8 ± 21.3 (SE) birds killed on the road during that time period. Opportunistic surveying by park service staff detected between 0% and 100% of carcasses we estimated to be present, depending on the date. Standardized surveys are needed going forward to estimate annual variation in carcass numbers and to determine effectiveness of mortality mitigation. Moreover, further research can use these estimates to understand the contribution of road mortality to population trends. © 2018 The Wildlife Society.
Improving surface heat flux estimation for a large lake through model optimization and two‐point calibration: The case of Lake Geneva
Authors: Rahaghi Abolfazl Irani , Lemmin Ulrich , Cimatoribus Andrea , Bouffard Damien , Riffler Michael , Wunderle Stefan , Barry David Andrew 
Published: September 2018

AbstractNet Surface Heat Flux (SurHF) was estimated from 2008 to 2014 for Lake Geneva (Switzerland/France), using long‐term temperature depth profiles at two locations, hourly maps of reanalysis meteorological data from a numerical weather model and lake surface water temperatures from calibrated satellite imagery. Existing formulas for different heat flux components were combined into 54 different total SurHF models. The coefficients in these models were calibrated based on SurHF optimization. Four calibration factors characterizing the incoming long‐wave radiation, sensible, and latent heat fluxes were further investigated for the six best performing models. The combination of the modified parameterization of the Brutsaert equation for incoming atmospheric radiation and of similarity theory‐based bulk parameterization algorithms for latent and sensible surface heat fluxes provided the most accurate SurHF estimates. When optimized for one lake temperature profile location, SurHF models failed to predict the temperature profile at the other location due to the spatial variability of meteorological parameters between the two locations. Consequently, the optimal SurHF models were calibrated using two profile locations. The results emphasize that even relatively small changes in calibration factors, particularly in the atmospheric emissivity, significantly modify the estimated long‐term heat content. The lack of calibration can produce changes in the calculated heat content that are much higher than the observed annual climate change‐induced trend. The calibration improved parameterization of bulk transfer coefficients, mainly under low wind regimes.
On estimation of coastal wave parameters and wave‐induced shear stresses
Authors: Xiong J. , Wang Y. P. , Gao S. , Du J. , Yang Y. , Tang J. , Gao J. 
Published: September 2018

AbstractWave parameters, e.g., wave height, near‐bed wave orbital velocity, and wave‐induced shear stresses, are important hydrodynamic parameters for sediment processes in coastal oceans. Wave orbital velocity is particularly critical in sediment resuspension. Several algorithms to calculate wave orbital velocity have been proposed, including linear wave theory, spectrum, and Joint North Sea Wave Project methods, but the validity of these algorithms in relatively shallow waters is not well understood. In this study, we compared the wave parameters obtained by different instruments and algorithms at four sites, one within the intertidal zone with a mean depth of 1 m and the remainder three in deeper offshore water with mean depths of 15–30 m. We found a high consistency of the estimated wave height, peak wave period, and wave orbital velocity among different datasets and different algorithms at the offshore sites, while there were significant discrepancies at the shoreline site. Using Ursell number, our study suggests that it is reliable to apply any of the three algorithms and different instruments (acoustic Doppler velocimeter and buoy) in deeper water. However, for very shallow water, it is recommended to use the measured high‐frequency velocity and spectrum method to calculate wave orbital velocity, and use wave gauge instrument or zero‐crossing algorithm to obtain wave height and period information. Finally, the effect of turbulence and bedform morphology on wave‐induced shear stress is discussed: without removing the turbulence or taking onto account bedforms (e.g., ripples), the orbital velocity will be remarkably over‐estimated or under‐estimated.