bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Extracellular Volume in Hemodialysis Patients Using Intradialytic Blood Pressure Slopes
Authors: Liu Hao , Lu Rong , Shastri Shani , Sonderman Mark , Van Buren Peter Noel 
Published: February 2018

<b><i>Background/Aims:</i></b> Extracellular volume (ECV) overload is a mortality risk factor in hemodialysis patients, but no standard approach exists to objectively assess this clinically. We aimed to quantify relationships between slopes of repeated intradialytic blood pressure (BP) measurements and ECV. <b><i>Methods:</i></b> In a cross-sectional study of 71 hemodialysis patients, we calculated BP slopes from all intradialytic measurements using Gaussian regression. We measured extracellular and total body water (TBW) with bioimpedance spectroscopy. We analyzed unconditional and conditional associations between BP slope and volume metrics with mixed linear models and sensitivity analyses using non-linear intradialytic BP trajectory. <b><i>Results:</i></b> Mean systolic intradialytic BP slope (IBPS) was –0.06 (0.1) mm Hg/min. Post-dialysis extracellular water (ECW)/weight was the volume metric mostly strongly associated with slope (<i>r</i> = 0.34, <i>p</i> = 0.007 for unconditional analysis; β = 1.45, <i>p</i> = 0.001 for conditional analysis). Among subjects with post-dialysis systolic BP ≥130 mm Hg, the association strengthened (<i>r</i> = 0.40, <i>p</i> = 0.006; β = 1.42, <i>p</i> = 0.003). ECV was more strongly associated with the BP slope than with pre-dialysis, post-dialysis, or delta systolic BP (<i>r</i> = –0.07, 0.19, 0.28; <i>p</i> = 0.6, 0.1, 0.03). In nonlinear models, BP trajectory also had the strongest association with post-dialysis ECW/body weight (<i>p</i> &#x3c; 0.001). <b><i>Conclusions:</i></b> In hypertensive hemodialysis patients, measurements of ECV excess are more strongly associated with IBPSs than with pre-dialysis, post-dialysis, or change in systolic BP. Among varying volume metrics, post-dialysis ECW/weight has the strongest association with these slopes. Determining IBPS is a novel method to optimize clinical assessment of ECV in hemodialysis patients.
Alleged Christian Crosses in Herculaneum and Pompeii
Authors: Cook John Granger 
Published: February 2018

Abstract
The thesis that cil 4, 10062 and two cruciform artefacts in Herculaneum and Pompeii are Christian crosses, which indicate a pre-Vesuvian Christian presence in Campania, cannot be sustained. cil 4, 10062 most probably portrays a scrawl. The cruciform indentation in a wall of Herculaneum was probably left by the support for a shelf. The bas relief of a bakery in Pompeii likely indicates some kind of baker’s tool.
Deconstructing Religion: Some Thoughts on Where We Go From Here — A Hermeneutical Proposal
Authors: Hedges Paul 
Published: February 2018

Abstract
This paper overviews contemporary debates on the deconstruction / historization of the category ‘religion’. It argues that a hard deconstruction which seeks to suggest the term is an empty signifier and analytically useless is unfounded philosophically and empirically. However, a soft deconstruction which accepts the problems of employing the term, especially as found in the World Religions Paradigm, but suggests that ‘religion’ remains a useful tool to describe a specific social reality, is well founded. The article extends current debates by showing how philosophical hermeneutics, especially as exemplified by Hans-Georg Gadamer’s work, supports the soft deconstructive approach and further shows the conceptual inadequacy of hard deconstruction.
Multiple Religious Belonging and the ‘Deconstruction’ of Religion
Authors: Oostveen Daan F. 
Published: February 2018

Abstract
In this article I briefly survey the meaning of ‘religion’ in the context of multiple religious belonging and the consequences of the so-called deconstruction of religion to it. I argue that we can distinguish three hermeneutics on religion and religious diversity in theology and religious studies: a hermeneutics of multiple religions, a hermeneutics of hybrid religiosity and a hermeneutics of deconstruction. Both a hermeneutics of hybrid religiosity and a hermeneutics of deconstruction challenge the common understanding of multiple religious belonging as belonging to multiple religious traditions. Following Wouter Hanegraaff and Paul Hedges, I will argue that the deconstruction of religion could make us aware that the idea of religious traditions are ultimately reified imaginative formations, which give rise to the so-called ‘World Religions’ paradigm. Following from this, we can learn how the imagination of multiple religions to which an individual can belong is always in interaction with the imagination of a hybrid or dynamic religious belonging.
Storytelling in the Meteorology Classroom
Authors: Knox John A. , Croft Paul J. 
Published: February 2018

The current explosion of scientific information available to science educators puts increasing pressure on conventional educational approaches. One educational technique that (a) facilitates the communication of essential knowledge, (b) is supported by cognitive science theory, and (c) is easily implemented in the atmospheric science classroom is the reformulating of lectures into stories. “Storytelling” here is understood to describe the oral or written communication of a “connected narrative of important events.” Stories differ from other pedagogical approaches, such as the traditional fact-laden lecture, through the network of multiple linkages between different characters, events, and facts in a story. Facts in a lecture may simply follow one after another; events in a story, by contrast, must follow from previous facts and the logic in the story itself.
An account is given of the lead author's use of storytelling in an atmospheric dynamics course at the University of Wisconsin—Madison. In the 2-hour-per-week laboratory, the course material was cast in the form of stories—stories that framed the basic knowledge, conveyed key concepts, and related key topics to one another. Stories were delivered orally in class and through an informal laboratory workbook. The rationale for this approach, the stories told, and the students' reactions are described. An example of storytelling in a global climate change course is also provided to illustrate the usefulness of storytelling in a wide range of meteorology courses.
Solid Variant of Aneurysmal Bone Cyst of the Temporal Bone
Authors: Saez Neil , Sharma Giriraj K. , Barnes Christian H. , Lu Yuxin , Hsu Frank P. , Huoh Kevin C. , Djalilian Hamid R. , Lin Harrison W. 
Published: February 2018

Objectives: Aneurysmal bone cysts (ABC) are benign, rapidly growing osteolytic lesions. Solid variant of ABC (SVABC) is a rare subtype of ABC that has not been reported in the temporal bone. Methods: We report the case of a 6-year-old boy presenting with a slowly enlarging bony protuberance over the right zygomatic/malar eminence region. Computed tomography and magnetic resonance imaging demonstrated a 2.6 × 5.8 × 5.1 cm temporal bone mass involving the right mastoid, petrous, and temporal squamosal calvarium, with extradural intracranial extension to the middle cranial fossa. Results: The patient underwent preoperative embolization of feeder arteries followed by combined neurosurgical and neurotologic resection. Histopathology revealed characteristic ABC features with interspersed areas of intralesional osteoid formation. Conclusion: Solid variant of ABCs are rare lesions of the skull base that present a diagnostic challenge given their unique radiographic and histologic features. Thorough cytogenetic evaluation is warranted to rule out potential malignant secondary causes. Early surgical resection is essential due to the risk of intracranial extension. This is the first report of ABC of any type with concurrent involvement of the squamous, mastoid, and petrous portions of the temporal bone and the first report of SVABC of the temporal bone.
Volumetric and linear measurements of lung tumor burden from non-gated micro-CT imaging correlate with histological analysis in a genetically engineered mouse model of non-small cell lung cancer
Authors: Gallastegui Aitor , Cheung James , Southard Teresa , Hume Kelly R 
Published: February 2018

In vivo micro-computed tomography (CT) imaging allows longitudinal studies of pulmonary neoplasms in genetically engineered mouse models. Respiratory gating increases the accuracy of lung tumor measurements but lengthens anesthesia time in animals that may be at increased risk for complications. We hypothesized that semiautomated, volumetric, and linear tumor measurements performed in micro-CT images from non-gated scans would have correlation with histological findings. Primary lung tumors were induced in eight FVB mice with two transgenes (FVB/N-Tg(tetO-Kras2)12Hev/J; FVB.Cg-Tg(Scgb1a1-rtTA)1Jaw/J). Non-gated micro-CT scans were performed and the lungs were subsequently harvested. In the acquired micro-CT scans, measurements of all identified tumors were determined using the following methods: semiautomated three-dimensional (3D) volume, ellipsoid volume, Response Evaluation Criteria in Solid Tumors (RECIST; sum of largest axial (i.e., transverse) diameter from five tumors), sum of largest axial diameters from all tumors (modified RECIST), and average axial diameter. For histological analysis, all five lung lobes were analyzed and the tumor area was summed from measurements made on five histological sections that were 300 µm apart from each other (covering a total depth of 1200 µm). All micro-CT measurement methods had very strong correlation with histological tumor burden (Pearson’s correlation coefficient, 0.87 ( p = 0.0053) −0.98 ( p < 0.0001)). The only methods found to have different correlations were the semiautomated 3D method and the RECIST method (Williams’ test for dependent overlapping correlations, p = 0.013). Our results suggest quantification of lung tumor burden from non-gated micro-CT imaging will reflect histological differences between mice and can therefore be used for between-group comparisons or when concerns about systemic health of research animals may limit lengthy anesthetic procedures.
Which Assessment Method of Malnutrition in Head and Neck Cancer?
Authors: Saroul Nicolas , Pastourel Rémy , Mulliez Aurélien , Farigon Nicolas , Dupuch Vincent , Mom Thierry , Boirie Yves , Gilain Laurent 
Published: February 2018

ObjectiveTo assess the value of several diagnostic methods of nutritional status during the initial management of a head and neck cancer.Study DesignSingle‐center prospective study.SettingTertiary referral center.Subjects and MethodsNinety patients with head and neck cancer participated in the study. Assessment of their nutritional status was made with anthropometric, biological, body, and muscle measurements (the last by computed tomography: L3 muscle mass index [L3MMI]). Assessment of muscle performance (functional reflection of nutritional status) was made via the Short Physical Performance Battery test. The malnutrition thresholds were set according to the literature.ResultsMean body mass index (BMI) was 24.6 ± 5.4 kg/m2. Mean weight loss and albumin levels were –4.5 ± 10.5 kg and 37.1 ± 5.2 g/L, respectively. Fourteen percent of patients were diagnosed as malnourished on the basis of BMI, 54% according to the Nutritional Risk Index (NRI), and 58% by L3MMI. There was 64% agreement between NRI and L3MMI (P <. 001). All patients identified as malnourished by BMI were considered as such by the other assessment methods; however, many malnourished patients had normal or high BMI. The Short Physical Performance Battery score was low particularly among patients considered to be the most undernourished by the other methods.ConclusionNRI and L3MMI are the best methods to identify patients as being malnourished. Functional muscle assessment can determine the severity of malnutrition.
Patient Decision Making in Vestibular Schwannoma: A Survey of the Acoustic Neuroma Association
Authors: Moshtaghi Omid , Goshtasbi Khodayar , Sahyouni Ronald , Lin Harrison W. , Djalilian Hamid R. 
Published: February 2018

ObjectiveTo assess the decision‐making process of patients with vestibular schwannoma (VS).Study DesignPatients with VS completed a voluntary survey over a 3‐month period.SettingSurveys were distributed online through email, Facebook, and member website.Subjects and MethodsAll patients had a diagnosis of VS and were members of the Acoustic Neuroma Association (ANA). A total of 789 patients completed the online survey.ResultsOf the 789 participants, 474 (60%) cited physician recommendation as a significant influential factor in deciding treatment. In our sample, 629 (80%) saw multiple VS specialists and 410 (52%) sought second opinions within the same specialty. Of those who received multiple consults, 242 (59%) of patients reported receiving different opinions regarding treatment. Those undergoing observation spent significantly less time with the physician (41 minutes) compared to surgery (68 minutes) and radiation (60 minutes) patients (P<. 001). A total of 32 (4%) patients stated the physician alone made the decision for treatment, and 29 (4%) felt they did not understand all possible treatment options before final decision was made. Of the 414 patients who underwent surgery, 66 (16%) felt they were pressured by the surgeon to choose surgical treatment.ConclusionDeciding on a proper VS treatment for patients can be complicated and dependent on numerous clinical and individual factors. It is clear that many patients find it important to seek second opinions from other specialties. Moreover, second opinions within the same specialty are common, and the number of neurotologists consulted correlated with higher decision satisfaction.
Predictors of Readmission and Reoperation in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism
Authors: Roche Ansley M. , Brant Jason A. , Chai Raymond L. 
Published: February 2018

ObjectiveIdentify risk factors for 30‐day reoperation and readmission after parathyroidectomy for primary hyperparathyroidism.Study DesignRetrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database from 2012 through 2014.Subjects and MethodsPatients undergoing parathyroidectomy and parathyroid reexploration for primary hyperparathyroidism. Univariate and multivariate analyses were conducted to determine risk factors for reoperation and readmission.ResultsOf the 9439 patients who underwent parathyroidectomy, 72 patients underwent 1 reoperation in the first 30 days after surgery, and 8 patients underwent 2 reoperations. The most common reasons were hematoma (25%) and persistent hyperparathyroidism (15.9%). Risk factors included smoking (odds ratio [OR], 1.86; 95% confidence interval [CI], 0.97‐3.31), insulin‐dependent diabetes (OR, 2.38; 95% CI, 1.02‐4.86), and history of bleeding disorder (OR, 3.95; 95% CI, 1.48‐8.79). In total, 182 (1.9%) patients were readmitted within 30 days of surgery; the most common cause was hypocalcemia (17.0%). Risk factors included operative time (hours) (OR, 1.3; 95% CI, 1.1‐1.5), insulin‐dependent diabetes mellitus (OR, 2.01; 95% CI, 1.2‐3.3), dyspnea with moderate exertion (OR, 5.77; 95% CI, 0.86‐14.67), and age (decade) (OR, 1.16; 95% CI, 1.02‐1.32). Patients undergoing outpatient surgery were less likely to be readmitted (OR, 0.49; 95% CI, 0.35‐0.69) or undergo reoperation (OR, 0.44; 95% CI, 0.27‐0.73).ConclusionsThirty‐day reoperation rate after parathyroidectomy was low and most commonly occurred due to hematoma. Risk factors for readmission were multifactorial and associated with perioperative factors, patient factors, and medical comorbidities. Preoperative counseling for patients at increased risk of readmission and reoperation may decrease these rates.
Domestic Workplace: Critical Crossroads of Unorganized Labour and Management
Authors: Poddar Debasis 
Published: February 2018

In the world of work at large, domestic workplace constitutes an altogether different space for hitherto labour jurisprudence and more so in the given age of liberalization-privatization-globalization worldwide. The way workforce used to get together at workplace and thereby unionized to form trade union in factory, mine, plantation and other establishments cannot take place anyway in case of domestic workplace. No wonder that the same attracts attention of relevant stakeholders on several counts, for example, labour on the one side and management on the other side. The author explores peculiarity of such workplace, issues involved therein along with means and methods to address major hurdles for management and labour studies to grapple with one among the least explored workplaces of the world. The forthcoming paragraphs are meant to grapple with relative (read comparative) vulnerability for members of the workforce inside a space otherwise meant for private individual use, albeit with the potential for abuse to gross detriment of the workforce and, at times, of the management as well. With recent focus of the International Labour Organization (ILO), the labour wing of the UN administration and one among the oldest institutions meant for global governance since the League of Nations regime, a unique trajectory of labour jurisprudence is on its wise to save stakeholders of the workplace from drudgery, if not vagary, of injustice with impunity. The hitherto private space is thereby increasingly converted to public space during its working hours in technical sense of the term and thereby subjected to the rule of law genre available elsewhere outside.
Integrated palliative care is about professional networking rather than standardisation of care: A qualitative study with healthcare professionals in 19 integrated palliative care initiatives in five European countries
Authors: den Herder-van der Eerden Marlieke , van Wijngaarden Jeroen , Payne Sheila , Preston Nancy , Linge-Dahl Lisa , Radbruch Lukas , Van Beek Karen , Menten Johan , Busa Csilla , Csikos Agnes , Vissers Kris , van Gurp Jelle , Hasselaar Jeroen 
Published: February 2018

Background: Integrated palliative care aims at improving coordination of palliative care services around patients’ anticipated needs. However, international comparisons of how integrated palliative care is implemented across four key domains of integrated care (content of care, patient flow, information logistics and availability of (human) resources and material) are lacking. Aim: To examine how integrated palliative care takes shape in practice across abovementioned key domains within several integrated palliative care initiatives in Europe. Design: Qualitative group interview design. Setting/participants: A total of 19 group interviews were conducted (2 in Belgium, 4 in the Netherlands, 4 in the United Kingdom, 4 in Germany and 5 in Hungary) with 142 healthcare professionals from several integrated palliative care initiatives in five European countries. The majority were nurses ( n = 66; 46%) and physicians ( n = 50; 35%). Results: The dominant strategy for fostering integrated palliative care is building core teams of palliative care specialists and extended professional networks based on personal relationships, shared norms, values and mutual trust, rather than developing standardised information exchange and referral pathways. Providing integrated palliative care with healthcare professionals in the wider professional community appears difficult, as a shared proactive multidisciplinary palliative care approach is lacking, and healthcare professionals often do not know palliative care professionals or services. Conclusion: Achieving better palliative care integration into regular healthcare and convincing the wider professional community is a difficult task that will take time and effort. Enhancing standardisation of palliative care into education, referral pathways and guidelines and standardised information exchange may be necessary. External authority (policy makers, insurance companies and professional bodies) may be needed to support integrated palliative care practices across settings.
Association of cardiovascular risk factors on myocardial perfusion and fibrosis in asymptomatic individuals: cardiac magnetic resonance study
Authors: Cha Min Jae , Kim Sung Mok , Kim Hyun Su , Kim Yiseul , Choe Yeon Hyeon 
Published: February 2018

Background Myocardial perfusion reserve index (MPRI) and extracellular volume fraction (ECV) on cardiac magnetic resonance (CMR) are known to quantify coronary microvascular dysfunction and myocardial fibrosis, respectively. Purpose To demonstrate that cardiovascular risk factors such as hypertension, diabetes, hyperlipidemia, and smoking are correlated with MPRI and ECV on CMR in asymptomatic individuals. Material and Methods Between October 2013 and July 2014, 196 individuals underwent CMR. After excluding those with chest pain, arrhythmia, and obstructive coronary artery disease, participants were divided into five groups: those without risk factor (n = 26) and those with one (n = 43), two (n = 35), three (n = 24), or four (n = 6) risk factors. MPRI and ECV were obtained on perfusion CMR and pre- and post-T1 mapping, respectively. Results A total of 134 asymptomatic individuals (109 men, 25 women; mean age = 54.4 ± 7.08 years; body mass index [BMI] = 24.96 ± 2.76 kg/m2; Framingham risk score [FRS] = 7.71 ± 5.21) were included. The Jonckheere-Terpstra test demonstrated trends of increasing BMI, FRS, and left ventricular mass index (all P values < 0.001), but decreasing MPRI ( P = 0.001) with increasing numbers of risk factors. Stepwise multiple linear regression demonstrated that an increasing number of cardiovascular risk factors was an independent predictor of MPRI ( P = 0.001). However, there was no significant association between the number of risk factors and ECV ( P = 0.99). Conclusion We demonstrated that an increasing number of cardiovascular risk factors is significantly associated with reduced MPRI, but not with ECV on CMR.
Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood, human milk, and the umbilical cord
Authors: Deminice Thalia Manfrin Martins , Ferraz Ivan Savioli , Monteiro Jacqueline Pontes , Jordão Alceu Afonso , Ambrósio Lívia Maria Cordeiro Simões , Nogueira-de-Almeida Carlos Alberto 
Published: February 2018

Objectives To analyse intake of vitamin A (VA) and retinol concentrations in maternal blood, breast milk (BM), and the umbilical cord (UC) of newborns, and to determine the associations among these variables. Methods We performed a cross-sectional, epidemiological study of 180 mother–newborn dyads. Maternal and UC blood samples and BM were collected. VA intake by the mother over 30 days was assessed using a questionnaire. Results Mean retinol concentrations in maternal serum, the UC, and BM were 0.65 ± 0.27, 0.36 ± 0.18, and 2.95 ± 2.70 µmol/L, respectively. Retinol concentrations <0.70 µmol/L were found in 57.2% of maternal blood samples and in 94.9% of UC samples. A total of 27.9% of BM samples showed retinol concentrations <1.05 µmol/L. Mean VA intake by the mothers was 1041.33 ± 1187.86 µg retinol activity equivalents/day and was inadequate (<550 µg retinol activity equivalents/day) in 44.7%. Conclusions High proportions of insufficient retinol concentrations were observed in the UC, maternal blood, and BM. A high percentage of pregnant women had inadequate VA intake. Mothers with insufficient serum retinol concentrations had newborns with lower retinol concentrations in the UC. Higher retinol concentrations were observed in maternal blood and the UC with a higher VA intake.