bluuebunny/crossref_metadata_2025_split huggingface dataset:
РОЛЬ ФОЛІЄВОЇ КИСЛОТИ У ПОПЕРЕДЖЕННІ ВРОДЖЕНИХ ВАД РОЗВИТКУ: РЕЗУЛЬТАТИ АНОНІМНОГО АНКЕТУВАННЯ ЖІНОЧОГО НАСЕЛЕННЯ ЛЬВІВСЬКОЇ ОБЛАСТІ
Authors: Sharhorodska Ye. B. , Shkolnyk O. S. , Potapov I. A. , Rachkevych O. S. , Makukh H. V. 
Published: July 2019

Мета дослідження – вивчення обізнаності жіночого населення Львівської області про роль фолієвої кислоти (ФК) у попередженні вроджених вад розвитку плода (ВВР).
Матеріали та методи. Проведено опитування вагітних жінок Львівської області та аналіз 811 анкет респондентів. Вивчали питання стосовно вживання зазначеного препарату: дози (100, 200, 400 або 500 мкг), до та під час даної вагітності, тривалості прийому препарату, до зачаття та перші три місяці вагітності, а також обізнаності населення відносно преконцепційної дії фолієвої кислоти.
Результати дослідження та їх обговорення. Аналіз даних анкет показав, що з 811 жінок проживали в місті 622 (76,69 %), а 189 (23,31 %) – в селі. Вивчення паритету вагітності показало, що значно більше було жінок із І та ІІ вагітністю (48,20 % та 33,97 % відповідно). Найбільш поінформованими про значення ФК були жінки, вагітні вперше (30,83 %) та вдруге (25,40 %), з них значно частіше були жительки міста. Більшість респондентів отримала знання про ФК від медиків – 58,08 %, причому достовірно більше цих жінок було з міста, ніж із села (46,0 % та 12,08 % відповідно, Р<0,001). Лише 40,44 % вживали ФК до вагітності протягом від одного до трьох місяців. Всього близько 1/3 (37,73 %) жінок вживали ФК у дозі 400 мкг. Причому 26,26 % респондентів застосовували препарат протягом 2 місяців до вагітності, та 41,92 % – трьох місяців під час вагітності. Значно частіше це були мешканки міста, ніж села (Р<0,001).
Висновки. Встановлено, що серед жіночого населення Львівської області поінформованість про фолієву кислоту як кращу справжню профілактику вроджених аномалій розвитку плода є недостатньою. Це стосується даних про сам препарат, його дозу прийому та термінів і тривалості вживання.
A Cross‐Cohort Study Examining the Associations of Metabolomic Profile and Subclinical Atherosclerosis in Children and Their Parents: The Child Health CheckPoint Study and Avon Longitudinal Study of Parents and Children
Authors: Juonala Markus , Ellul Susan , Lawlor Debbie A. , Santos Ferreira Diana L. , Carlin John B. , Cheung Michael , Dwyer Terence , Wake Melissa , Saffery Richard , Burgner David P. 
Published: July 2019

Background

High‐throughput nuclear magnetic resonance profiling of circulating metabolites is suggested as an adjunct for cardiovascular risk evaluation. The relationship between metabolites and subclinical atherosclerosis remains unclear, particularly among children. Therefore, we examined the associations of metabolites with carotid intima‐media thickness (
cIMT
) and arterial pulse wave velocity (
PWV
).

Methods and Results

Data from two independent population‐based studies was examined; (1) cross‐sectional associations with
cIMT
and
PWV
in 1178 children (age 11–12 years, 51% female) and 1316 parents (mean age 45 years, 87% female) from the CheckPoint study (Australia); and (2) longitudinal associations in 4249 children (metabolites at 7–8 years,
PWV
at 10–11 years, 52% female), and cross‐sectional associations in 4171 of their mothers (mean age 48 years,
cIMT
data) from
ALSPAC
(The Avon Longitudinal Study of Parents and Children;
UK
). Metabolites were measured by the same nuclear magnetic resonance platform in both studies, comprising of 69 biomarkers. Biophysical assessments included body mass index, blood pressure,
cIMT
and
PWV
. In linear regression analyses adjusted for age, sex, body mass index, and blood pressure, there was no evidence of metabolite associations in either children or adults for
cIMT
at a 10% false discovery threshold. In CheckPoint adults, glucose was positively, and some high‐density lipoprotein‐cholesterol derived measures and amino acids (glutamine, histidine, tyrosine) inversely associated with PWV.

Conclusions

These data suggest that in children circulating metabolites have no consistent association with
cIMT
and
PWV
once adjusted for body mass index and blood pressure. In their middle‐aged parents, some evidence of metabolite associations with
PWV
were identified that warrant further investigation.
Characterisation of vasodilatory responses in the presence of the CGRP receptor antibody erenumab in human isolated arteries
Authors: Rubio-Beltrán Eloísa , Labastida-Ramírez Alejandro , Haanes Kristian A , van den Bogaerdt Antoon , Bogers Ad JJC , Dirven Clemens , Danser AH Jan , Xu Cen , Snellman Josefin , MaassenVanDenBrink Antoinette 
Published: July 2019

Background Migraine is associated with activation of the trigeminovascular system, release of calcitonin gene-related peptide (CGRP) and dilation of dural arteries. Novel treatments target calcitonin gene-related peptide or its receptor, which are present in all vascular beds, raising cardiovascular concerns. Erenumab is a human CGRP-receptor antibody approved for the prophylactic treatment of migraine. Methods We characterised the relaxant responses to CGRP in the absence and presence of erenumab (1 μM) in isolated human middle meningeal, internal mammary and (proximal and distal) coronary arteries. Furthermore, in human internal mammary arteries from cardiovascularly-compromised patients, we assessed the pharmacological specificity of erenumab by investigating whether the vasodilatory responses to acetylcholine, sodium nitroprusside, pituitary adenylate cyclase activating polypeptide-38 (PACAP), vasoactive intestinal peptide and nicardipine, along with the vasoconstrictor responses to dihydroergotamine, were modified by erenumab. Results Calcitonin gene-related peptide induced concentration-dependent vasodilatory responses in all vessels studied that were significantly antagonised by erenumab. In human internal mammary arteries from cardiovascularly-compromised patients, the responses to acetylcholine, sodium nitroprusside, PACAP, vasoactive intestinal peptide, nicardipine and dihydroergotamine were unaffected by erenumab. Conclusion Erenumab inhibits calcitonin gene-related peptide-induced vasodilatory responses in human middle meningeal arteries, human internal mammary arteries and human coronary arteries. Moreover, erenumab shows functional specificity as no interaction was observed with the relaxant responses to several vasodilators, nor the dihydroergotamine-dependent vasoconstrictor responses.
Prevalence, detection and associations of depression in Australian dialysis patients
Authors: Kwan Elaine , Draper Brian , Harvey Samuel B , Endre Zoltan H , Brown Mark A 
Published: July 2019

Objective: Depression in dialysis patients is often undetected despite associations with poor outcomes. The aim was to determine the prevalence and associations of depressive symptoms and physician recognition of depression within a typical Australian dialysis population. Method: A cross-sectional study examined haemodialysis and peritoneal dialysis patients of two hospitals in Sydney. Participants were screened for depression using the Hospital Anxiety and Depression Scale (HADS). Results: One hundred and ten patients completed the HADS. Subjects had a mean age of 63.7 years, 37% from a culturally and linguistically diverse background, and median dialysis duration of 2 years. Forty-one per cent of participants had significant depressive symptoms, of whom 42% had been diagnosed with depression by their clinicians. After adjustment for sociodemographic factors, having >10 medications prescribed, >3 hospitalisations in the last 12 months, and a history of depression were associated with depression. Conclusion: Depressive symptoms are prevalent in Australian dialysis patients. Robust evidence is needed on the effectiveness of treatments for depression in changing outcomes in chronic kidney disease.
Oxidative Stress Levels Throughout Pregnancy, at Birth, and in the Neonate
Authors: Moore Tiffany A. , Ahmad Iman M. , Schmid Kendra K. , Berger Ann M. , Ruiz R. Jeanne , Pickler Rita H. , Zimmerman Matthew C. 
Published: July 2019

Background: Oxidative stress is associated with poor perinatal outcomes. Little is known regarding the longitudinal levels of oxidative stress in the perinatal period or the correlation between maternal and neonatal oxidative stress levels. Objective: Describe and compare oxidative stress, specifically superoxide, superoxide dismutase, catalase, and glutathione levels, over the perinatal period. Study Design: Longitudinal descriptive design using a convenience sample of medically high- and low-risk pregnant women ( n = 140) from a maternal–fetal medicine and general obstetrics practice, respectively. Blood was obtained from women at 12–20 and 24–28 weeks’ gestation and during labor, from the umbilical cord at birth, and from neonates at 24–72 hr after birth. Levels of superoxide were measured using electron paramagnetic resonance (EPR) spectroscopy; antioxidants (superoxide dismutase, catalase, and glutathione) were measured using commercial assay kits. Relationships between oxidative stress levels at different time points were examined using nonparametric methods. Pregnancy outcome was collected. Results: Demographic variables, outcome variables, and oxidative stress levels in maternal blood, cord blood, and infants differed between medically high- and low-risk women. Descriptive patterns for oxidative stress measures varied over time and between risk groups. Significant correlations between time points were noted, suggesting intraindividual consistency may exist throughout the perinatal period. However, these correlations were not consistent across each medical risk group. Conclusion: EPR spectroscopy is a feasible method for the perinatal population. Results provide new information on perinatal circulating superoxide levels and warrant further investigation into potential relationships between prenatal and neonatal physiologic dysregulation of oxidative stress.
The iPhone Measure app level function as a measuring device for the weight bearing lunge test in adults: a reliability study
Authors: Banwell Helen A. , Uden Hayley , Marshall Nicole , Altmann Carlie , Williams Cylie M. 
Published: July 2019

AbstractBackgroundAnkle joint range of motion is a frequently assessed measure used by health care clinicians who manage lower limb pathologies to identify ankle equinus and/or other joint motion concerns that may negatively impact on function. The purpose of this study was to assess a new iPhone application (the level function of the ‘Measure application’), for measuring the weightbearing ankle lunge test in a healthy adult population (reliability) and measuring known angles (validity) when compared to a digital inclinometer.MethodsTo determine intra‐rater reliability, inter‐rater reliability and concurrent validity, 168 measures were conducted on 21 participants. Participants were preconditioned prior to assessment, and two experienced raters measured ankle dorsiflexion range of motion in the knee extended and knee flexed positions of the weight bearing lunge test, using an iPhone level function (of the Measure application) and a digital inclinometer in a randomised order, over two timepoints. Concurrent validity was also determined by comparison of measures of the two devices at known surface angles (0 and 15 degrees) in multiple planes. Reliability and validity were determined with intraclass correlation coefficients, concurrent validity was explored with the Bland Altman plot and an intraclass correlation coefficient. The Standard Error of the Mean and the minimal detectable change were also explored.ResultsThe intra‐rater reliability using the iPhone and inter‐rater reliability using the digital inclinometer, in the knee extended position, were ICC 0.85 respectively, indicating good reliability. All other intra‐rater reliability and inter‐rater reliability for both devices and both leg positions were over ICC 0.90, indicating excellent reliability. Concurrent validity between the two devices on a flat and known angle surface were ICC 1.0 (Limits of Agreement − 1.0 to 0.61), indicating excellent validity, with good validity demonstrated by a Bland Altman plot of all measures in all positions (ICC of 0.84 (Limits of agreement = − 4.51 to 6.49)).ConclusionThe use of the iPhone level measure, within the Measurement App has demonstrated to be an easy and reliable measurement tool to determine ankle joint dorsiflexion during the weightbearing lunge test in healthy adults.
Caffeine, Type of Coffee, and Risk of Ovarian Cancer: A Dose–Response Meta-Analysis of Prospective Studies
Authors: Salari-Moghaddam Asma , Milajerdi Alireza , Surkan Pamela J , Larijani Bagher , Esmaillzadeh Ahmad 
Published: July 2019

Abstract

Context
Prospective studies on caffeine and different types of coffee intake in relation to the risk of ovarian cancer have shown conflicting results.

Objective
The aim of the present study was to perform a dose–response meta-analysis of cohort studies on the association between dietary caffeine intake, different types of coffee consumption, and the risk of ovarian cancer.

Data sources
PubMed/Medline, ISI Web of Science, Scopus, and EMBASE were searched to identify relevant studies reported until October 2018.

Study selection
Prospective cohort studies that had considered caffeine or different types of coffee as the exposure variable and ovarian cancer as the main outcome variable or as one of the outcome variables were included in our systematic review and meta-analysis. Two of us independently screened 9344 publications. A total of 14 cohort studies were included in the meta-analysis.

Data extraction
Two of us independently extracted the data. Any disagreements were resolved in consultation with the principal investigator.

Results
Combining 13 effect sizes, we found no substantial association between coffee consumption and risk of ovarian cancer [risk ratio (RR), 1.08; 95% CI, 0.89 to 1.33]. Also, one additional cup daily of coffee consumption was marginally associated with an increased risk of ovarian cancer (RR, 1.02; 95% CI, 0.99 to 1.05; P = 0.21; I2 = 0.0%; Pheterogeneity = 0.68). No statistically significant association was observed between caffeine intake or caffeinated or decaffeinated coffee consumption and the risk of ovarian cancer.

Conclusions
We found no statistically significant association between caffeine intake or different types of coffee and the risk of ovarian cancer.
Adrenalectomy Completely Cured Hypertension in Patients With Familial Hyperaldosteronism Type I Who Had Somatic KCNJ5 Mutation
Authors: Lin Yu-Fang , Peng Kang-Yung , Chang Chia-Hui , Hu Ya-Hui , Wu Vin-Cent , Chueh Jeff S , Wu Kwan-Dun 
Published: July 2019

Abstract

Context
Familial hyperaldosteronism type I (FH-I) or glucocorticoid-remediable aldosteronism (GRA) is caused by unequal crossing over of the steroid 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes. Somatic KCNJ5 mutations have not been reported in patients with GRA; therefore, the appropriate treatment and prognosis of such concurrent cases remain unknown.

Case Description
Two siblings of a Taiwanese family with GRA were found to have adrenal adenomas and somatic KCNJ5 mutations. Complete clinical cure was achieved after unilateral adrenalectomy. Furthermore, the conversion site of the chimeric gene was identified by direct sequencing.

Conclusions
We report the coexistence of a somatic KCNJ5 mutation and GRA. Patients with GRA whose blood pressure management develops resistance to glucocorticoid treatment could therefore benefit from a lateralization test. The promising outcomes after unilateral adrenalectomy presented in this report offer new perspectives for further research into various PA subtypes.
Exhibition Reviews
Authors: Colón Zoë , Tulliach Anna , Gradassi Tea , Zylak Mattia , Grenier Béatrice , Watlington Emily , Frappier Valérie , Dunlop Alanna , Cyrus Jason , Murphy Diana K. , Handley-Derry Elizabeth , MacDonald Kristie , Fellini Dallas 
Published: July 2019

CO-WINNER OF THE 2019 JOURNAL OF CURATORIAL STUDIES EMERGING WRITER AWARD
ART FOR A NEW UNDERSTANDING: NATIVE VOICES, 1950s TO NOW Curated by Mindy N. Besaw, Candice Hopkins and Manuela Well-Off-Man, Crystal Bridges Museum of American Art, Bentonville, 6 October 2018 – 7 January 2019
CO-WINNER OF THE 2019 JOURNAL OF CURATORIAL STUDIES EMERGING WRITER AWARD
MAQDALA 1868 Curated by Alexandra Jones, Victoria and Albert Museum, London, 5 April 2018 – 30 June 2019
RUNNER-UP FOR THE 2019 JOURNAL OF CURATORIAL STUDIES EMERGING WRITER AWARD
LAWRENCE ABU HAMDAN, EARWITNESS THEATRE Curated by Ellen Greig, Chisenhale Gallery, London, 21 September – 9 December 2018
JASMINA CIBIC: EVERYTHING THAT YOU DESIRE AND NOTHING THAT YOU FEAR Curated by Cheryl Sim, DHC/ART Foundation for Contemporary Art, Montreal, 25 October 2018 – 3 March 2019
FRANÇOISE SULLIVAN Curated by Marc Lanctôt, Musée d’art contemporain de Montréal, Montreal, 20 October 2018 – 20 January 2019
SADAÂNE AFIF: THIS IS ORNAMENTAL Curated by Anne Faucheret, Kunsthalle Wien, Vienna, 9 September 2018 – 18 November 2018
DAVID HARTT: in the forest Oakville Galleries in Gairloch Gardens, Oakville, 23 September 2018 – 6 January 2019
DAYNA MCLEOD, INTIMATE KARAOKE, LIVE AT UTERINE CONCERT HALL Curated by FADO Performance Art Centre, co-presented with SummerWorks Performance Festival, The Theatre Centre, Toronto, 15 August 2018
HEAVENLY BODIES: FASHION AND THE CATHOLIC IMAGINATION Curated by Andrew Bolton, Metropolitan Museum of Art, New York, 10 May – 8 October 2018
CARSTEN HÖLLER AND STEFANO MANCUSO, THE FLORENCE EXPERIMENT Curated by Arturo Galansino, Palazzo Strozzi, Florence, 19 April – 26 August 2018
COME UP TO MY ROOM 2018 Curated by Christophe Jivraj, Jana Macalik and Lukus Toane, Gladstone Hotel, Toronto, 18 – 21 January 2018
Antarctic biennale Curated by Alexander Pronomarev and Nadim Samman, Antarctica, various locations, 17 – 27 March 2017
LIL MIQUELA @lilmiquela, 2016 – ongoing, www.instagram.com/lilmiquela
Progressive vowel height harmony in Proto-Kikongo and Proto-Bantu
Authors: Goes Heidi , Bostoen Koen 
Published: July 2019

AbstractThe systematic comparison of the different types of progressive Vowel Height Harmony (pVHH) attested within the Kikongo Language Cluster (KLC) leads to the conclusion that this common Bantu process of long-distance assimilation cannot be reconstructed to Proto-Kikongo. The ‘(a)symmetric-pVHH’ and ‘back-pVHH’ patterns, the two main and structurally different kinds of pVHH within the KLC, emerged independently and relatively late within two distinct subgroups, viz. South Kikongo and North Kikongo respectively. Moreover, the ‘(a)symmetric-pVHH’ pattern further spread from a South Kikongo focal area coinciding with the heartland of the Kongo kingdom to other parts of the KLC through contact-induced dialectal diffusion. Furthermore, the historical-comparative evidence from the KLC suggests that neither symmetric nor asymmetric pVHH should be reconstructed to Proto-Bantu, the most recent common ancestor of all Bantu languages.
Hunting for signs: Exploring unspoken networks within the Kalahari Basin
Authors: Mohr Susanne , Fehn Anne-Maria , de Voogt Alex 
Published: July 2019

AbstractIn this article we present comparative data on visual hunting signals from the Kalahari Basin Area of southern Africa, encompassing three Kalahari Khoe-speaking (Ts’ixa, Buga, ǁAni) and one Kx’a-speaking group (Juǀ’hoan). For the comparison, an analysis of handshapes, handedness and iconicity in the individual data sets was conducted. Being applied in analyses of gestures and (partly) sign languages, these parameters reveal significant similarities and differences between the individual systems. We find that the systems documented most likely constitute an areal feature that transcends the boundaries of genealogical linguistic affiliation and may ultimately contribute to a better understanding of population contact and local networks in the Kalahari Basin AreaSprachbund.
Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets
Authors: Mao Hong , Diekmann Robin , Liang Hai Po H. , Cogger Victoria C. , Le Couteur David G. , Lockwood Glen P. , Hunt Nicholas J. , Schüttpelz Mark , Huser Thomas R. , Chen Vivien M. , McCourt Peter A.G. 
Published: July 2019

Abstract
Single-molecule localization microscopy (SMLM) provides a powerful toolkit to specifically resolve intracellular structures on the nanometer scale, even approaching resolution classically reserved for electron microscopy (EM). Although instruments for SMLM are technically simple to implement, researchers tend to stick to commercial microscopes for SMLM implementations. Here we report the construction and use of a “custom-built” multi-color channel SMLM system to study liver sinusoidal endothelial cells (LSECs) and platelets, which costs significantly less than a commercial system. This microscope allows the introduction of highly affordable and low-maintenance SMLM hardware and methods to laboratories that, for example, lack access to core facilities housing high-end commercial microscopes for SMLM and EM. Using our custom-built microscope and freely available software from image acquisition to analysis, we image LSECs and platelets with lateral resolution down to about 50 nm. Furthermore, we use this microscope to examine the effect of drugs and toxins on cellular morphology.
Crystal structure of catena-{poly[bis(O,O′-diethyldithiophosphato-S)-(μ2-1,2-bis(4-pyridylmethylene)hydrazine-N,N′)-zinc(II)] di-acetonitrile solvate}, {C20H30N4O4P2S4Zn ⋅ 2 C2H3N}n
Authors: Tan Yee Seng , Tiekink Edward R.T. 
Published: July 2019

Abstract
C24H36N6O4P2S4Zn, triclinic, P1̄ (no. 2), a = 11.2847(2) Å, b = 12.6967(3) Å, c = 13.6595(3) Å, α = 64.738(2)°, β = 72.181(2)°, γ = 76.681(2)°, V = 1673.68(7) Å3, Z = 2, R
gt(F) = 0.0225, wR
ref(F
2) = 0.0582, T = 100(2) K.
Application of the Boston Technical Performance Score to intraoperative echocardiography
Authors: Bellsham-Revell Hannah R. , Deri Antigoni , Caroli Silvia , Durward Andrew , Miller Owen I. , Mathur Sujeev , Saundankar Jelena , Anderson David R. , Austin B. Conal , Salih Caner , Pushparajah Kuberan , Simpson John M. 
Published: July 2019

Abstract

Background The Technical Performance Score (TPS) developed by Boston Children’s Hospital showed surgical outcomes correlate with adequacy of technical repair when implemented on pre-discharge echocardiograms. We applied this scoring system to intraoperative imaging in a tertiary UK congenital heart surgical centre.

Methods After a period of training, intraoperative TPS (epicardial and/or transesophageal echocardiography) was instituted. TPS was used to inform intraoperative discussions and recorded on a custom-made database using the previously published scoring system. After a year, we reviewed the feasibility, results and relationship between the TPS and mortality, extubation time and length of stay.

Results From 01 September 2015 to 04 July 2016, there were 272 TPS procedures in 251 operations with 208 TPS recorded. Seven patients had surgery with no documented TPS, three had operations with no current TPS score template available. Patients left the operating theatre with TPS optimal in 156 (75%), adequate 34 (16%) and inadequate 18 (9%). Of those with an optimal score on leaving theatre, ten had more than one period of cardiopulmonary bypass. All four deaths <30 days after surgery (1.9%) had optimal TPS. There was a statistically significant difference in extubation times in the RACHS category 4 patients (3 days vs 5 days, P < 0.05) and in PICU and total length of stay in the RACHS category three patients (2 and 8 days vs 12.5 and 21.5 days respectively) if leaving theatre with an inadequate result.

Conclusions Application of intraoperative TPS is feasible and provides a way of objectively recording intraoperative imaging assessment of surgery. An ‘inadequate’ TPS did not predict mortality but correlated with a longer ventilation time and longer length of stay compared to those with optimal or adequate scores.