bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of lymphadenectomy on the survival of patients with stage I ovarian clear cell carcinoma
Authors: Li Tingting , Tan Chunyan , Xie Sixia , Wang Hongjing 
Published: November 2024

ObjectiveTo assess the impact of lymphadenectomy on the survival of patients with stage I ovarian clear cell carcinoma (OCCC).MethodsThe records of 93 patients with stage I OCCC treated between January 2012 and December 2019 were reviewed retrospectively. The relationships between survival outcomes and the number and region of removed lymph nodes (LNs) were assessed, and the independent prognostic factors were analyzed.ResultsThe median number of LNs resected in 93 patients was 24. These patients were divided into two groups based on the median number; overall survival (OS) and recurrence-free survival (RFS) differed significantly between the two groups. Patients were also grouped by the region of the LNs: the pelvic lymph node dissection (PLND) and PLND and para-aortic. Moreover, no differences in OS or RFS were observed between the two groups. Cox regression analysis demonstrated that the number of removed LNs was a significant and independent prognostic factor for poor RFS.ConclusionThis study exhibited that the number of removed LNs, as an important measure of adequate lymphadenectomy for stage I OCCC, contributed to improved RFS and OS. An independent prognostic factor for stage I OCCC was the number of dissected LNs.
Development and validation of a MRI-radiomics-based machine learning approach in High Grade Glioma to detect early recurrence
Authors: Pignotti Fabrizio , Ius Tamara , Russo Rosellina , Bagatto Daniele , Beghella Bartoli Francesco , Boccia Edda , Boldrini Luca , Chiesa Silvia , Ciardi Chiara , Cusumano Davide , Giordano Carolina , La Rocca Giuseppe , Mazzarella Ciro , Mazzucchi Edoardo , Olivi Alessandro , Skrap Miran , Tran Houng Elena , Varcasia Giuseppe , Gaudino Simona , Sabatino Giovanni 
Published: November 2024

PurposePatients diagnosed with High Grade Gliomas (HGG) generally tend to have a relatively negative prognosis with a high risk of early tumor recurrence (TR) after post-operative radio-chemotherapy. The assessment of the pre-operative risk of early versus delayed TR can be crucial to develop a personalized surgical approach. The purpose of this article is to predict TR using MRI radiomic analysis.MethodsData were retrospectively collected from a database. A total of 248 patients were included based on the availability of 6-month TR results: 188 were used to train the model, the others to externally validate it. After manual segmentation of the tumor, Radiomic features were extracted and different machine learning models were implemented considering a combination of T1 and T2 weighted MR sequences. Receiver Operating Characteristic (ROC) curve was calculated with relative model performance metrics (accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV)) at the best threshold based on the Youden Index.ResultsModels performance were evaluated based on test set results. The best model resulted to be the XGBoost, with an area under ROC curve of 0.72 (95% CI: 0.56 - 0.87). At the best threshold, the model exhibits 0.75 (95% CI: 0.63 - 0.75) as accuracy, 0.62 (95% CI: 0.38 - 0.83) as sensitivity 0.80 (95% CI: 0.66 - 0.89 as specificity, 0.53 (95% CI: 0.31 - 0.73) as PPV, 0.88 (95% CI: 0.72 - 0.94) as NPV.ConclusionMRI radiomic analysis represents a powerful tool to predict late HGG recurrence, which can be useful to plan personalized surgical treatments and to offer pertinent patient pre-operative counseling.
Dancing with care: promoting social integration and participation in community activities for older adults
Authors: An Jianzeng , Xia Chun , Xu Jia , Li Weiwei , Ding Jianwen 
Published: November 2024

BackgroundIt is common for older adults to move to urban communities after retirement, living with their adult children and caring for grandchildren in China. This impacts their social networks and, consequently, their psychological and physical health. However, research on proactive ways to mitigate the negative effects of social dislocation is lacking. This study examined how dancing with care (DWC), a new form of preventative care, promotes social integration among older adults in Chinese communities, focusing specifically on participants’ experiences related to community engagement, mutual support, volunteer activity, social connections, and advanced learning through their involvement with DWC.MethodsSemi-structured interviews were conducted with 60 older adults who regularly participated in DWC in communities in southern China.ResultsDWC’s dimensions play a vital role in addressing the social integration of older adults. Through DWC, older adults participate in community activities, engage in mutual support, volunteer in various activities, develop social connections, and learn different things, including the use of advanced technologies.ConclusionDWC addresses older people’s social integration by providing opportunities to be involved in the community. It provides a promising path for older adults to actively engage in the revival of social capital within their social networks in the community. This study offers valuable insights for enhancing social involvement for older adults.
Implementation of suicide bereavement support: a scoping review
Authors: Nicholls Tescha , Krysinska Karolina , Reifels Lennart , Kartal Dzenana , Andriessen Karl 
Published: November 2024

IntroductionApproximately one in five people will experience a death by suicide during their lifetime. Struggling to understand their experiences, people bereaved by suicide often require formal support including support groups, online resources and discussion forums. While previous research has focused on examining experiences of grief, little is known about the implementation of support programs for people bereaved by suicide.MethodsAdhering to PRISMA-ScR guidelines, eight databases were searched for peer-reviewed studies that focused on the strategies or evaluation of the implementation of suicide postvention programs.ResultsSixteen studies met the eligibility criteria. A narrative synthesis of study findings mapped to the Proctor implementation framework shows that a variety of implementation outcomes have been assessed by different studies; however, there is limited use of formal implementation frameworks to guide analysis.DiscussionRecommendations from this review indicate the need for consistent terminology and better utilisation of implementation frameworks to guide postvention research and provide a well-rounded view of implementation. Increasing the use of reliable and validated tools to measure implementation outcomes will also increase the rigour of implementation research in this field.Systematic review registrationhttps://doi.org/10.17605/OSF.IO/4RB92.
Impact of Irrigation Management on Salinity and Volume of Drainage Water in an 8000 ha Irrigation District in the Ebro Basin (NE Spain)
Authors: Altés Víctor , Pascual Miquel , Villar Josep Maria 
Published: November 2024

When irrigation is introduced in a region, it adds salts and mobilizes those already present in the soil, changing the soil-plant-atmosphere continuum. These changes may lead to higher salt loads in the drainage water which, in turn, can have an impact on waters further downstream. Knowing the dynamics of these loads at the sub-basin scale is key to accounting for the possible impact that irrigation may have and to determining what improvements could be applied. This study aimed to characterise the different salt types present and to investigate drainage salt loads and their dependence upon irrigation input and their implications in irrigation management in a new, and well-managed, 8000 ha irrigation district located in the Ebro basin, NE Spain. In addition, it is relevant to highlight that the Ebro basin suffered a period of significant drought in 2023. As a result, irrigation restrictions were applied in many irrigation districts. We sought to investigate how these reductions influenced irrigation return flows and salt discharges within a selected irrigation district. The present study was undertaken during the irrigation periods of 2021, 2022, and 2023. We monitored water inputs and outputs in two representative sub-basins belonging to the Algerri-Balaguer irrigation district (Ebro basin, NE Spain). We also analysed water inputs and outputs in order to characterise and establish the salt balances in both of the sub-basins that we studied. Our results showed that during 2023, a reduction in irrigation delivery of 31% led to a reduction in drainage volume of 73%, resulting in a decrease in salt exports through drainage of 70%. These data revealed that the application of irrigation restrictions not only led to an increased availability of downstream water resources, but also to a decrease in drainage volume and salt load, resulting in an improvement in irrigation management by farmers. However, it should also be underlined that this drastic reduction in irrigation was, in turn, responsible for a reduction in yield. Re-utilising drainage waters and/or improving irrigation management at the field scale may help to find this point of balance in areas with high water demands.
Burnout Among Physicians of Specialties Dedicated to Liver Transplantation
Authors: Sanchez-Antolín Gloria , Blanco-Fernández Gerardo , Campos-Varela Isabel , Ruiz Patricia , Álamo José M. , Otero Alejandra , Pascual Sonia , Lladó Laura 
Published: November 2024

Burnout is increasingly relevant among healthcare professionals. The aim of this study is to describe the prevalence of burnout and other parameters of professional satisfaction among different specialists dedicated to Liver Transplantation (LT) in transplant teams. A working group from the Spanish Society of LT designed a survey with 39 questions evaluating the prevalence of parameters related to professional satisfaction, including burnout. It was distributed among 496 specialists dedicated to liver transplantation in Spanish transplant teams. Responders included surgeons (49%), hepatologists (27%), anesthesiologists (16%), intensivists (4%), and other specialties (4%). Among responders, 78% reported some degree of burnout. Moreover, 46% of responders did not see themselves working in transplantation in 5 years. The rates of burnout and dissatisfaction among anesthesiologists and surgeons were higher than other specialists. The highest levels of dissatisfaction were in economic remuneration and work–life balance. Being younger than 60 years old and non-head of department showed to be risk factors of burnout. In conclusion, the prevalence of burnout among LT physicians in Spain was notably high. Among the various specialties, anesthesiologists and surgeons exhibited the highest dissatisfaction rates. The results of this work may be of interest to healthcare management and planning.
Average Case (s, t)-Weak Tractability of L2-Approximation with Weighted Covariance Kernels
Authors: Chen Jia , Yan Huichao 
Published: November 2024

We study the multivariate L2-approximation problem APPd defined over a Banach space in the average case setting. The space is equipped with a zero-mean Gaussian measure with a weighted covariance kernel, which depends on parameter sequences α={αj}j∈N and β={βj}j∈N with 1<α1≤α2≤⋯ and 1≥β1≥β2≥⋯>0. In this paper, two interesting weighted covariance kernels are considered, which model the importance of the covariance kernels. Under the absolute error criterion or the normalized error criterion, we discuss (s,t)-weak tractability of the L2-approximation problem APP={APPd}d∈N from a Banach space whose zero-mean Gaussian measure has the above two weighted covariance kernels for some positive numbers s and t in the average case setting. Here, (s,t)-weak tractability means how the information complexity behaves as a function of dt and ε−s for large dimension d and small threshold ε. In particular, for all s>0 and t∈(0,1), we find the matching sufficient and necessary condition on the parameter sequences α={αj}j∈N and β={βj}j∈N to obtain (s,t)-weak tractability under the absolute error criterion or the normalized error criterion in the average case setting. We describe (s,t)-weak tractability by the matching sufficient and necessary condition, which reflects symmetry.
Primary bone non-Hodgkin lymphoma with vertebra involvement
Authors: Yuksek Muhammed Erkam , Karagoz Gulsum , Arac Densel , Keskin Fatih 
Published: November 2024

NHL accounts for less than 5% of all adult cancers. Bone lymphomas, mostly NHL, may cause extradural cord compression. Non-Hodgkin lymphomas (NHL) represent a group of heterogeneous neoplasms originating from the bone marrow or lymph nodes. NK cell tumours with CD56 positive immunophenotype are a very rare and heterogeneous group of diseases among bone lymphomas presenting with nonspecific clinical and radiological findings. Although there is no gold standard treatment for this disease, there are various forms of treatment such as chemotherapy, immunotherapy, surgery or radiotherapy. In this report, a primary bone lymphoma with vertebral and femur involvement, which is treated with chemotherapy, radiotherapy and autologous transplantation after surgical treatment, is presented.
PITFALLS IN THE GAMMA KNIFE TREATMENT OF PITUITARY ADENOMAS
Authors: Perin Radu Daniel , Stoica Fery , Neamtu Daniela 
Published: November 2024

Purpose
In the multimodal treatment of pituitary adenomas Radiosurgery is mainly used as a secondary treatment after the medical treatment and neurosurgery. Yet the Gamma Knife Treatment isn’t possible without some risks and complications.

Material and Methods
In this retrospective study 841 treatments were included. The patients were treated in the Radiotherapy Laboratory of the “Bagdasar-Arseni” Emergency Clinical Hospital, between 2004 and 2024, initially using a Gamma Knife 4C device, then a Gamma Knife Perfection and now an Esprit model. Most of the cases underwent surgery beforehand. The purpose of the treatment was tumor growth control and, in functioning adenomas, hormone hypersecretion control with the preservation of normal pituitary functions and the normal functioning of surrounding structures.

Due to the treatment guidelines, we used during the treatments, very few complications occurred. There were 7 cases of hypopituitarism, 3 cases of oculomotor palsies, 6 cases of pituitary apoplexy. There were no recorded cases of significant optic neuropathy or carotid stenosis.
Results and Conclusions
The Gamma Knife treatment determined, in almost all cases, the stopping of tumor growth and in most cases a reduction in tumor volume. Complications (optic neuropathy, hypopituitarism, damage to the nerves inside the cavernous sinus) were very scarce. Gamma Knife Radiosurgery, if basic rules are followed, is an efficient and safe method in the treatment of pituitary adenomas.
EFFICACY OF DEEP BRAIN STIMULATION
Authors: Radu Crina , Dabu A. , Tudor C. , Teleanu D. 
Published: November 2024

During the last decade deep brain stimulation (DBS) has been established as a highly effective surgical therapy not only for advanced Parkinson’s disease, but also for dystonia or essential tremor. It is defined as a neuromodulatory technique that delivers adjustable electrical stimuli to different key targets such as the subthalamic nucleus (STN), the internal globus pallidus (GPI) or the ventral intermediate nucleus (VIM).

This comparative analysis aims to guide in tailoring individual patient profiles, optimizing outcomes by selecting the most appropriate target area based on symptomatology and patient specific factors and has the end goal to improve motor function, quality of life and diminish possible side effects.

The existing clinical trials were reviewed with results that showed no significant differences between the STN-DBS and GPI-DBS groups in Unified Parkinson’s Disease Rating Scale (UPDRS) III scores within 1st year post-surgery. STN-DBS allowed greater reduction in medication dosages for patients, whereas GPI-DBS provided greater relief from psychiatric symptoms. Dyskinesia scores were also greatly improved by GPI stimulation. Moreover, for patients with dystonia, both GPIDBS and STN- DBS were successful in improving quality of life, patients with primary dystonia having a better response overall in terms of efficacy of the procedures than those with secondary dystonia.

45 cases of STN-DBS and 5 cases of GPI- DBS procedures were safely performed in our clinic using a stereotactic frame with significant motor symptoms relief and medication reduction.

In conclusion, further research comparing the side effects and quality of life is needed to refine target selection criteria and to optimize long-term management of patients with Parkinson’s disease and other movement disorders.

References
“Deep brain stimulation of globus pallidus internus and subthalamic nucleus in Parkinson’s disease: a multicenter, retrospective study of efficacy and safety.” Aug 2023 Volume 45, pages 177–185, (2024)
“Deep brain stimulation treating dystonia: a systematic review of targets, body distributions and etiology classifications.” Nov 2021 Volume 15 – 2021.
https://doi.org/10.3389/fnhum.2021.757579.
“STN versus GPi Deep brain stimulation for action and rest tremor in parkinson’s disease.” Oct 2020 Volume 14 – 2020.
https://doi.org/10.3389/fnhum.2020.578615.
“STN versus GPi Deep brain stimulation for dyskinesia improvement in advanced Parkinson’s disease: A meta-analysis of randomized controlled trials.” 2021 Feb: 201:106450. doi: 10.1016/j.clineuro.2020.106450.
“Where are we with deep brain stimulation? a review of scientific publications and ongoing research.”
https://doi.org/10.1159/00052137.
ODONTOID FRACTURE TREATED WITH CEMENT-AUGMENTED DIRECT ANTERIOR SCREW OSTEOSYNTHESYS IN ELDERLY PATIENTS
Authors: Teplý Ondřej , Nesnídal Petr , Fiedler Jiří 
Published: November 2024

Purpose of the Study
The authors retrospectively evaluate data of a cohort of patients operated on with the same surgical technique over a 10-year period with a mean age of 81.7 years for odontoid fracture.

Material and Methods
Between 2012 and 2021 we performed cement-augmented direct anterior screw osteosynthesis in. The mean follow-up period was 2.7 years.

Results
A total of 41 screws were inserted, 2 screws in 7 patients, Total of 33 patients (97%; N=34) odontoid type II fracture, 1x type III (1%; N = 34. We lost 5 patients from follow up.

Radiologically we found 20x fusion (69%; N = 29), 7x pseudoarthrosis stable (type I and II) (24.1%; N = 29), 2x loosening, failure (type III and IV) (7%; N = 29). We assessed as stable condition 27 times (93%; N = 29). On the follow-ups with
no major reported pain VAS 2 (6.9 to 2 postoperatively) (p < 0.05), 26 (90%; N = 29) of living patients return to original activities at 1 year postoperatively. Perioperatively, we experienced 16 times cement leakage (47%; N=34).
Conclusions
In our institution, now the method of first choice for type II odontoid fractures in geriatric patients. It has a reasonable operative risk, preserve rotations of the upper cervical spine and quality of life of these patients (satisfaction 90%) and achieve stability of fracture in 93% of patients.
CEREBRAL ANEURYSM CHARACTERISTICS AND SURGICAL OUTCOMES
Authors: Toader Corneliu , Covache-Busuioc Razvan-Adrian , Glavan Luca-Andrei , Luca-Husti Ionut Florin , Ciurea Alexandru Vlad 
Published: November 2024

Background
Intracranial aneurysms (IAs) represent life-threatening neurosurgical emergencies. This study aims to provide a comprehensive analysis of 346 patients with 416 IAs treated using microsurgical clipping between 2016/2022, focusing on demographic characteristics, aneurysm features, and surgical outcomes.

Methods
This retrospective study involved patients from the National Institute of Neurology and Neurovascular Diseases in Bucharest, Romania. Variables examined included aneurysm localization, diameter, neck dimensions, rupture status, and postoperative complications. The study employed statistical analysis using Python and adhered to the Declaration of Helsinki principles (2013).
Results
- Patient Demographics: 346 patientsaa: mean age over 30 years. A gender discrepancy was noted, with a higher prevalence of IAs in females (3:1 ratio).
- Aneurysm Characteristics: Anterior communicating artery and middle cerebral artery (246 cases, 71% of total). Diameters ranged from 2-12.5 mm in 323 cases (93.3%), with neck dimensions primarily between 1-5 mm in 292 cases (84.4%).
- Rupture and Complications: A substantial prevalence of ruptured aneurysms was observed in 309 patients (89.3%). Hemorrhage was noted in 312 cases (90.1%), and 101 patients (29.2%) experienced vasospasm. The Fisher score distribution highlighted severity, with 142 cases (41%) at score 3.
- Surgical Outcomes: The Glasgow Outcome Scale (GOS) indicated favorable results in 261 patients (75.4%), while 84 patients (24.3%) succumbed postoperatively, with 70 patients (20.2%) due to neurological causes. Postoperative complications included 25 reoperations (7.2%) and 71 cases of osteomyelitis (20.5%).
- Predictive Factors: Significant risk factors included arterial hypertension (mostly grade II), atherosclerosis, obesity, and diabetes, influencing both intraoperative phases and postoperative infection rates.

Conclusion
The study underscores the critical nature of timely surgical intervention in IA cases, particularly for ruptured aneurysms. The findings emphasize the need for tailored, multidisciplinary treatment strategies and ongoing research to improve surgical protocols and patient outcomes. The comprehensive analysis of preoperative, intraoperative, and postoperative variables provides valuable insights into managing intracranial aneurysms, highlighting the complexities and challenges in treating this condition.