bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paternal Adaptation and Affecting Factors in Men: A Meta-Synthesis
Authors: Eskandari Narges , Simbar Masoumeh , Vadadhir AbuAli , Bageri Asma 
Published: December 2018

Background and purpose: Few studies have been carried out on paternal adaptation and there is no comprehensive definition and theory about paternal adaptation in men. This study aimed to extract the concept of paternal adaptation in men and factors affecting it based on qualitative research conducted on paternal experiences.Materials and Methods: This research was a systematic review and meta-synthesis, including 10 articles, that combined the findings of qualitative research related to men`s experiences of transition to fatherhood, using meta-ethnographic method.Results: Findings of this study were categorized into three themes including representations and signs of paternal adaptation, paternal adaptation facilitators and paternal adaptation obstacles. Based on the study findings, parental satisfaction, understanding paternal transition and development, being capable of fulfilling paternal responsibilities, and being capable of handling the current situation were found to be the representations and signs of paternal adaptation. Adaptation facilitators included attempt to manage present situation, cooperation in the child rearing, time lapse, use of educational resources, readiness to become a parent, utilization of support resources, and parental leave. On the other hand, adaptation obstacles were found to be as follows: damaged parental relationship, paternal role ambiguity, expectations above the father's abilities, lack of time for oneself, damaged marital relationship, occupational concerns, insufficient social support, false myths and misbeliefs, and financial problems. Conclusion: Based on the findings of the current study, enhancing fathers' parenting knowledge and skills, creating educational opportunities, supplying support resources, preparing the setting for father`s continued presence and participation in the family, and offering paternal models to the society may facilitate fathers' paternal adaptation.
EVOLUTION OF THE VIEWS ON IMPORTANCE OF BLOOD PRESSURE VARIABILITY
Authors: Troitskaya E. A. , Kotovskaya Yu. V. , Kobalava Zh. D. 
Published: December 2018

The phenomenon of variability of blood pressure (BP) has been studied for a long time, but recently, it has made a comeback in scientiﬁ c literature. This is mostly due to the fact that numerous studies have conﬁrmed the importance of BP variability in predicting cardiovascular risk, although the effect of various parameters of variability does not have the same level of cardiovascular risk due to different underlying pathophysiological mechanisms. Interest in BP variability is due to and based on a series of studies carried out by P. Rothwell et al., who analyzed variability in BP in heterogeneous populations. In particular, the analysis of the ASCOT-BPLA trial showed high signiﬁ cance of intervisit variability of ВР and predicted stroke and coronary events. In light ofthese data, the variability of ВР is a promising new target for antihypertensive therapy. A statistically signiﬁcant decrease of this index indicates the stability of the achieved results following treatment. The most convincing evidence in this respect, are those for the combination of amlodipine and perindopril.
THE СLINICAL IMPACT OF PULMONARY ARTERY DISTENSIBILITY INDEX IN PATIENTS WITH PULMONARY HYPERTENSION
Authors: Kazimli A. V. , Ryzhkov A. V. , Goncharova N. S. , Berezina A. V. , Naymushin A. V. , Moiseeva O. M. 
Published: December 2018

Objective.Vascular remodeling in patients with pulmonary artery hypertension (PAH) may be assessed by measurement of contrast magnetic-resonance imaging (CMRI) derived pulmonary artery distensibility (PAD) index. The objective of our study was to investigate whether PAD index could be used as a marker for the evaluation of PAH severity.Design and methods.Forty four patients with PAH (mean age — 42,8 ± 14,5 years, males:females = 11:33) were enrolled: 29 patients with idiopathic pulmonary arterial hypertension, 4 subjects with corrected congenital heart disease, 3 subjects with scleroderma PAH and 8 patients with inoperable chronic thromboembolic pulmonary hypertension. All patients underwent 6-minute walk test, right heart catheterization (RHC), heart ultrasound (ECHO), CMRI, cardiopulmonary exercise testing, and serum N-terminal-pro-brain natriuretic peptide (NT-proBNP) level was defined.Results.PAD index was decreased in PAH patients 11,9 % (9,3-19,7). Patients with decreased PAD index < 20 % had higher NT-proBNP level, lower tricuspid annular systolic velocity and right ventricle/left ventricle ratio by ECHO. Patients with PAD index < 20 % had higher pulmonary artery systolic blood pressure (96,5 ± 22,4 versus 77,9 ± 19,4 mmHg; p < 0,05), and reduced cardiac output which were determined by RHC (3,98 ± 1,1 versus 4,95 ± 1,21 l/min; p < 0,05). Decreased VO2peak was found in patients with PAD index < 20 % (14,8 versus 18,8 ml/min/kg; p = 0,05).Conclusions.PA distensibility index may be used for noninvasive assessment of PAH severity and progression.
HYPERTENSION IN THYROTOXICOSIS AND ITS IMPACT ON LEFT VENTRICULAR HYPERTROPHY
Authors: Babenko A. Yu. , Grineva E. N. , Solntsev V. N. 
Published: December 2018

Objective. We present the results of the study assessing the frequency and character of hypertension in thyrotoxicosis, and its impact on left ventricular remodeling and cardiovascular prognosis.Results and conclusions. Our data demonstrated that hypertension, and predominantly systolic hypertension, is highly prevalent in thyrotoxicosis and affects left ventricular remodeling. All normotensive patients developed only eccentric left ventricular hypertrophy (LVH). The prevalence of LVH, and of its concentric forms increases with the elevation of blood pressure. Concentric LVH is associated with the high rate of atrial fi brillation and heart failure.
THE EFFECTS OF TRANSCATHETER RENAL DENERVATION ON BLOOD PRESSURE AND BRAIN STRUCTURAL CHANGES IN RESISTANT HYPERTENSION
Authors: Afanasieva N. L. , Pekarskiy S. E. , Mordovin V. F. , Semke G. V. , Ripp T. M. , Lichikaki V. A. , Vintizenko S. I. , Lukiyanenok P. I. , Karpov R. S. 
Published: December 2018

Objective.To study the changes of 24-hour blood pressure parameters and brain structure at follow-up after transcatheter renal denervation in resistant hypertension.Design and methods.We enrolled patients with verified resistant hypertension undergoing an intervention that included 4–8 applications of radiofrequency discharge in both renal arteries using a standard catheter5 F under the controlled temperature regimen (60 С0, 8 Watt, 2-minute application). The efficiency of the intervention was assessed by the office and 24-hour blood pressure decrease within 6 months after intervention. All subjects underwent magnetic resonance tomography («Magnetom-OPEN», «Siemens AG», Germany).Results.By the time of statistical analysis 45 subjects underwent renal denervation, there was not a single case of renal artery damage. At six-month follow-up a significant reduction of office blood pressure (-34,8/-17,2 mmHg; p < 0,00001/0,00001), and mean 24-hour blood pressure (-11,1/-7,1 mmHg; p < 0,001/0,001) was found. No increase of encephalopathy signs by magnetic resonance tomography was found. At the same time there was a reduction of the linear size of lateral ventricles of the brain, subarachnoid space, III ventricle of the brain, liquor volume in the lateral ventricles of the brain.Conclusions.Renal denervation is a safe method resulting in effective blood pressure reduction in resistant hypertension. It is associated with the positive changes of encephalopathy and liquor dynamics according to the magnetic resonance tomography.
ASSOCIATION OF rs9939609 FTO GENE POLYMORPHISM WITH METABOLIC SYNDROME AND ITS COMPONENTS IN RUSSIAN POPULATION
Authors: Khromova N. V. , Rotar O. P. , Erina A. M. , Shavshin D. A. , Alexeeva N. P. , Kostareva A. A. , Konradi A. O,. , Shlyakhto E. V. 
Published: December 2018

Objective. To study the association of genetic determinant (A-risk allele of rs9939609 SNP of FTO gene) with prevalence of metabolic syndrome (MS) and its components in residents of different Russian cities.Design and methods. We examined 425 patients with MS or its components from different cities of Russia (St Petersburg, Kursk, Kaliningrad), stratiied by sex and age [175 male (41,2 %) and 250 female (58,8 %), mean age — 47,2 ± 0,6 years]. All subjects were interviewed with special questionnaire. Physical examination included anthropometry (waist and hip circumferences, weight, height), blood pressure and heart rate registration. MS was deined according to NCEP-ATPIII as well as IDF (2005) and JIS (2009) criteria. Fasting plasma lipids and glucose were performed in all patients by Hitachi-902 equipment (Roche reagents). Genomic deoxyribonucleic acid (DNA) was puriied from peripheral blood lymphocytes and genotyping was performed using real time polymerase chain reaction method by allele-speciic probes (Applied Biosystems).Results. Among males with AA genotype waist and hip circumferences and weight were higher, compared to subjects with TA and TT genotypes (p = 0,0002, p = 0,001 and p = 0,01, respectively). There was a tendency to the increase of body mass index (BMI) in the group with AA genotype compared to subjects with TA and TT genotypes (29,7 ± 0,7; 27,6 ± 0,4 and 27,9 ± 0,3 kg/m2, respectively, р = 0,1). In our study AA genotype was associated with higher glucose level compared to TA and TT genotypes (5,6 ± 0,2; 5,0 ± 0,1 and 5,1 ± 0,1 mmol/l, respectively, p = 0,04). There was a tendency to the increase of the proportion of hypertensives among patients with AA genotype compared to TA and TT genotypes (70,5; 65,2 and 57 %, respectively, p = 0,18).Conclusion. In Russian population FTO genepolymorphism rs9969309 is associated not only with abdominal obesity, but also with other components of MS, including hyperglycemia and hypertension.
PATHOGENESIS OF AORTIC STENOSIS IN HYPERTENSIVE PATIENTS
Authors: Irtyuga O. B. , Zhiduleva E. V. , Kazakova E. E. , Moiseeva O. M. 
Published: December 2018

Objective. To assess osteoprotegerin (OPG) and soluble ligand receptor activator of transcription factor kappa-B (RANKL) levels in patients with aortic stenosis and systemic hypertension.Design and methods. Sixty-one patients with aortic valve stenosis (AVS) [31 patients with bicuspid aortic valve (BAV) and 30 patients with tricuspid aortic valve (TAV)] were examined. Thirty-two patients without heart diseases formed the control group. Serum levels of C-reactive protein, ОPG, sRANKL and lipid profile were assessed in all patients.Results. Elevated blood pressure (BP) was found in 93 % patients with TAV and in 71 % patients with BAV. Serum concentration of OPG was increased in patients with TAV and BAV vs control group. OPG concentration was negatively correlated with BP level only in patients with TAV. sRANKL level was increased only in patients with BAV. At the same time sRANKL level positively correlated with BP in patients with TAV. Conclusion. Systemic hypertension is the key risk factor for OPG/RANKL/RANK system activation in patients without congenital heart disease.
HYPERTROPHIC CARDIOMYOPATHY IN ELDERLY PEOPLE
Authors: Poliakova A. A. , Semernin E. N. , Streltcova A. A. , Kostareva A. A. , Gudkova A. Ya. 
Published: December 2018

Hypertrophic cardiomyopathy (HCM) is a leader in genetic structure of cardiovascular system. According to modern concepts, hypertrophic cardiomyopathy associated with mutations of sarcomere proteins is just one of the reasons leading to the left ventricular hypertrophy (LVH). Hypertrophic phenotype is also observed in a number of genetically and non-genetically related diseases. According to population-based studies conducted in the USA, Europe and Japan, the prevalence of HCM is 1:500. Apparently, the data obtained in these studies and based primarily on the phenotypic screening cannot be extrapolated to the full cohort of patients with HCM and reflect the general incidence of hypertrophic phenotype in different populations. There are some publications on the prevalence of HCM in the structure of LVH of unknown cause in children and adolescents. The features of the clinical course of HCM, risk stratification of sudden cardiac death (SCD), medical management in young and middle age are studied. At the same time elderly patients with unexplained LVH are the least studied cohort. Study of the natural history of the disease, risk factors for adverse events, including the SCD, the impact of comorbidity on the clinical manifestations of HCM in the elderly will contribute better understanding of this pathology, as well as a number of other diseases occurring under the guise of HCM. This can help to develop the algorithms for diagnosis, prediction criteria and management of LVH of unknown cause.
ON THE PROBLEM OF REGIONAL SPECIFICS OF MEDICAL CARE FOR HYPERTENSIVE PATIENTS
Authors: Sazanova G. Yu. 
Published: December 2018

Objective. The comparative study of the actual performance of diagnostic procedures for in-patients with essential hypertension. Design and methods. Evaluation of the execution of diagnostic standards was done by the assessment of the percentage of factual performance of recommended diagnostic methods according to primary medical reports. The methods used in the research are content analysis, analytical and statistical analysis.Results. Out of 44 (100 %) recommended parameters of standard diagnostic procedures only 16 (36,4 %) were performed in Central District Hospital, 18 (40,9 %) — in the city hospitals, 13 (29,5 %) — in the regional and federal hospitals. Out of 27 parameters only 12 were carried out with the required frequency 1,0, while the rest 15 parameters were carried out with the frequency 0,2–0,9. Few parameters were performed more frequently than it is recommended by the standards.Conclusion. The defined defects emphasize the necessity of the further analysis of the reasonability of the evaluation and performance of some diagnostic procedures at different levels of medical health care delivery.
THE PREVALЕNCE OF PRIMARY ALDOSTERONISM IN PATIENTS WITH UNCONTROLLED HYPERTENSION AND IN PATIENTS WITH PREVIOUSLY DETECTED ADRENAL INCIDENTALOMA: THE DATABASE OF ANTIHYPERTENSIVE SPECIALIZED CENTER
Authors: Avdonina N. G. , Zvartau N. E. , Emelianov I. V. , Vasilieva E. Yu. , Khokhunov O. A. , Polekhin S. A. , Grineva E. N. , Konradi A. O. 
Published: December 2018

Objective. To determine the prevalence of primary aldosteronism (PA) through routine practice — among patients visiting a specialized antihypertensive center due to uncontrolled hypertension or with adrenal incidentalomas.Design and methods. We included 314 patents with uncontrolled hypertension and 195 patients with incidentalomas. Aldosterone-renin ratio (ARR), hormonal tests and examination for exclusion of symptomatic hypertension were performed in all subjects. Results. PA diagnosis was confirmed in 27 patients with uncontrolled hypertension (8,6 % hypertensive patients) and in 17 % patients with adrenal incidentalomas. ARR increase as well as elevated aldosterone level were found in all subjects, and all of them had high PA risk.Conclusions. The prevalence of PA is 8,6 % patients with uncontrolled hypertension and 17 % patients with adrenal incidentalomas. ARR increase along with aldosterone level elevation should be considered at patient evaluation.
Optimal control problems for differential equations applied to tumor growth: state of the art
Authors: Rojas Clara , Belmonte-Beitia Juan 
Published: December 2018

Abstract
In this manuscript, we shall apply the tools and methods from optimal control to analyze various minimally parameterized models that describe the dynamics of populations of cancer cells and elements of the tumor microenvironment under different anticancer therapies. In spite of their simplicity, the analysis of these models that capture the essence of the underlying biology sheds light on more general scenarios and, in many cases, leads to conclusions that confirm experimental studies and clinical data. We focus on four applications: optimal control applied to compartmental models, brain tumors, drug resistance and antiangiogenic treatment.
Equivalent Analytical Functions of Sums of Sigmoid like Transcendental Functions
Authors: Takács J. 
Published: December 2018

Abstract
There is no mathematical solution to adding up transcendental functions other than numerical process. This paper put forward analytical method to model the sum of sigmoid like functions with an equivalent function. The Brillouin and Langevin as well as the error function, the tanh, sigmoid and the tan-

1 functions are investigated, their equivalent functions are calculated for four components and the error between the numerical (computer assisted) result and the equivalent function is tested for accuracy. The best modelling function, the most useful to include into mathematical operations, is pointed out finally, based on its performance and convenience. The paper intends to help people involved mostly in modelling hysteresis in Magnetism and other field of research in physics.
Access to Pain Management as a Human Right
Authors: Brennan Frank , Lohman Diederik , Gwyther Liz 
Published: December 2018

The concept of access to pain management as a human right has gained increasing currency in recent years. Commencing as individual advocacy, it was later embraced by the disciplines of pain medicine and palliative care and by mainstream human rights organizations.Today, United Nations and regional human rights bodies have accepted the concept and incorporated it into key human rights reports, reviews, and standards. We review the foundations in law of this right and the obligations that flow from it to governments. We analyze the nature and content of the obligation in the context of acute, chronic nonmalignant and cancer pain.Finally, we examine this right in light of the twin crises of inadequate access to pain management and the opioid crisis in the United States and other nations.
Transnational Tobacco Companies and New Nicotine Delivery Systems
Authors: Mathers Annalise , Hawkins Ben , Lee Kelley 
Published: December 2018

While the public health community has focused on the harm-reduction potential of new nicotine delivery systems (NNDSs) and, conversely, their potential for impeding overall efforts to prevent and reduce tobacco use, limited analysis has been conducted on the role of leading transnational tobacco companies (TTCs) in this rapidly growing market. Following aborted efforts during the 1980s and 1990s to develop reduced-risk products, TTCs have heavily invested in selected NNDS products since 2010 via acquisitions and internal research and development. This article catalogs and analyzes the patterns of investment in NNDSs by leading TTCs over time, and identifies differences in the companies’ approaches to NNDS product acquisition and development in specific markets globally. This analysis raises important questions regarding the companies’ intent, which appears to be to sustain, rather than replace, cigarette sales, and to increase their influence and credibility with respect to NNDS policy and regulation. We identify the need for greater public health vigilance and research to understand and respond to the increasingly significant role of NNDSs in TTCs’ global business strategies, to ensure that NNDSs advance, rather than hinder, tobacco control efforts.
SPE Technical Directors’ Outlook: Do Good, Then Do Better
Authors: Rassenfoss Stephen 
Published: December 2018

While leading initiatives to define and honor sustainability, Johana Dunlop said she is trying to balance “pride and accountability” in the oil and gas business.
The technical director in charge of health, safety, and environment regularly points out that those in the oil business make the world a better place by delivering energy that fuels economic progress. She also cautions that the industry needs to pay close attention to influential voices from outside the sector when setting standards for running a sustainable business.
Company earnings reports for 2018 showed that it was a generally good year for exploration and production, but the fall in oil prices late in the year warned against complacency in 2019. SPE technical directors all see room for improvement.
Erdal Ozkan, director for reservoir, said that it is time to stop being satisfied with methods leaving behind 70% of the oil in conventional reservoirs.
Terry Palisch, director for completions, said it is time to figure how to maximize production with the best combination of well spacing and completion designs in unconventional plays.
Ramona Graves, director of academia, is seeing a world of petroleum engineering programs that need to start sharing ideas about how to produce better-trained petroleum engineers.
Birol Dindoruk, director for management and information, wants to ensure that SPE continues to listen to groups pushing the industry to make the changes needed to maximize the value of its data assets.
Jeff Moss, director for drilling, says drillers need to focus on finding ways to reduce drilling costs with efficiency gains using tools such as automation to be competitive during cyclic service costs and oil prices.
Hisham Saadawi, director for production and facilities, sees great growth potential for natural gas, but innovative engineering ideas are required to address the problems that flow out of the wells along with the gas.
Intravitreal Dexamethasone Implants versus Intravitreal Anti-VEGF Treatment in Treating Patients with Retinal Vein Occlusion: A Meta-analysis
Authors: Shi Qian , Gao Lixiong , Zhou Lijun , Tian Chunyu , Li Na , Shao Weiyang , Peng Xiujun 
Published: December 2018

Abstract
Background: Retinal vein occlusion (RVO) is a common retinal venous disorder that causes vision loss. No specific therapy has been developed. Controversy exists regarding two treatments: intravitreal dexamethasone implants and anti-vascular endothelial growth factor (VEGF). The goal of this study is to compare the effectiveness and safety of dexamethasone implants and anti-VEGF treatment for RVO.
Methods: The PubMed, Embase, and Cochrane Library databases were searched for studies comparing dexamethasone implants with anti-VEGF in patients with RVO. Best-corrected visual acuity (BCVA), central subfield thickness (CST), intraocular pressure changes, conjunctival haemorrhage, reduced VA, and macular oedema were extracted from the final included studies. RevMan 5.3 was used to conduct the quantitative analysis and bias assessment.
Results: Four articles assessing 969 eyes were included. The anti-VEGF treatment showed better BCVA improvement (mean difference [MD] = -10.59, P < 0.00001) and more CST decrease (MD = -86.71 μm, P = 0.02) than the dexamethasone implants. However, the dexamethasone implants required fewer injections. As for adverse effects, the dexamethasone implants showed significantly higher intraocular pressure (IOP) and more cataracts than the anti-VEGF treatment. No significant differences were found in conjunctival haemorrhage, reduced VA, and macular oedema.
Conclusions: Anti-VEGF treatment showed better functional and anatomical improvement with less risk of IOP elevation and cataract formation compared to dexamethasone implants. Thus, anti-VEGF treatment is the first choice for treating RVO patients.

Keywords: dexamethasone intravitreal implant, anti-VEGF treatment, retinal vein occlusion, meta-analysis