bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered Tissue Composition, Microarchitecture, and Mechanical Performance in Cancellous Bone From Men With Type 2 Diabetes Mellitus
Authors: Hunt Heather B , Torres Ashley M , Palomino Pablo M , Marty Eric , Saiyed Rehan , Cohn Matthew , Jo Jonathan , Warner Stephen , Sroga Grazyna E , King Karen B , Lane Joseph M , Vashishth Deepak , Hernandez Christopher J , Donnelly Eve 
Published: March 2019

ABSTRACT
People with type 2 diabetes mellitus (T2DM) have normal-to-high BMDs, but, counterintuitively, have greater fracture risks than people without T2DM, even after accounting for potential confounders like BMI and falls. Therefore, T2DM may alter aspects of bone quality, including material properties or microarchitecture, that increase fragility independently of bone mass. Our objective was to elucidate the factors that influence fragility in T2DM by comparing the material properties, microarchitecture, and mechanical performance of cancellous bone in a clinical population of men with and without T2DM. Cancellous specimens from the femoral neck were collected during total hip arthroplasty (T2DM: n = 31, age = 65 ± 8 years, HbA1c = 7.1 ± 0.9%; non-DM: n = 34, age = 62 ± 9 years, HbA1c = 5.5 ± 0.4%). The T2DM specimens had greater concentrations of the advanced glycation endproduct pentosidine (+ 36%, P &lt; 0.05) and sugars bound to the collagen matrix (+ 42%, P &lt; 0.05) than the non-DM specimens. The T2DM specimens trended toward a greater bone volume fraction (BV/TV) (+ 24%, NS, P = 0.13) and had greater mineral content (+ 7%, P &lt; 0.05) than the non-DM specimens. Regression modeling of the mechanical outcomes revealed competing effects of T2DM on bone mechanical behavior. The trend of higher BV/TV values and the greater mineral content observed in the T2DM specimens increased strength, whereas the greater values of pentosidine in the T2DM group decreased postyield strain and toughness. The long-term medical management and presence of osteoarthritis in these patients may influence these outcomes. Nevertheless, our data indicate a beneficial effect of T2DM on cancellous microarchitecture, but a deleterious effect of T2DM on the collagen matrix. These data suggest that high concentrations of advanced glycation endproducts can increase fragility by reducing the ability of bone to absorb energy before failure, especially for the subset of T2DM patients with low BV/TV. © 2019 American Society for Bone and Mineral Research.
Single‐Dose Pharmacokinetics and Safety of Solriamfetol in Participants With Normal or Impaired Renal Function and With End‐Stage Renal Disease Requiring Hemodialysis
Authors: Zomorodi Katie , Chen Dan , Lee Lawrence , Lasseter Kenneth , Marbury Thomas 
Published: March 2019

AbstractSolriamfetol (JZP‐110), a selective dopamine and norepinephrine reuptake inhibitor with wake‐promoting effects, is renally excreted ∼90% unchanged within 48 hours. Effects of renal impairment and hemodialysis on the pharmacokinetics and safety of 75‐mg single‐dose solriamfetol were evaluated in adults with normal renal function (n = 6); mild (n = 6), moderate (n = 6), or severe (n = 6) renal impairment; and end‐stage renal disease (ESRD) with and without hemodialysis (n = 7). Relative to normal renal function, geometric mean area under the plasma concentration–time curve from time zero to infinity increased 53%, 129%, and 339%, and mean half‐life was 1.2‐, 1.9‐, and 3.9‐fold higher with mild, moderate, and severe renal impairment, respectively. Renal excretion of unchanged solriamfetol over 48 hours was 85.8%, 80.0%, 66.4%, and 57.1% in normal, mild, moderate, and severe renal impairment groups, respectively; mean maximum concentration and time to maximum concentration did not vary substantially. Decreases in solriamfetol clearance were proportional to decreases in estimated glomerular filtration rate. Geometric mean area under the plasma concentration–time curve from time zero to time of last quantifiable concentration increased 357% and 518% vs normal in ESRD with and without hemodialysis, respectively, with half‐life >100 hours in both groups. Over the 4‐hour hemodialysis period, ∼21% of solriamfetol dose was removed. Adverse events included headache (n = 1) and nausea (n = 1). Six days after dosing, 1 participant had increased alanine and aspartate aminotransferase, leading to study discontinuation. While these adverse events were deemed study‐drug related, they were mild and resolved. Results from this study combined with population pharmacokinetic modeling/simulation suggest that solriamfetol dosage adjustments are necessary in patients with moderate or severe but not with mild renal impairment. Due to significant exposure increase/prolonged half‐life, dosing is not recommended in patients with ESRD.
A New Gas Chromatography–Mass Spectrometry Method for Detecting and Quantifying Low Levels of Dimethyl Sulfate in Palm Oil‐Based Sulfonated Methyl Esters
Authors: Ping Bonnie Tay Yen , Aziz Haliza Abdul 
Published: March 2019

AbstractDimethyl sulfate (DMS) is a potential carcinogen that may be formed during the production of α‐sulfonated methyl ester (α‐SME). To date, there have been no published analytical methods for quantification of DMS in palm oil‐based α‐SME. The objective of the method development was to establish a simple and reliable method for quantifying and monitoring DMS from palm oil‐based α‐SME. The sample preparation prior to analysis involved extracting DMS from α‐SME using hexane. The gas chromatography–mass spectrometry (GC–MS) separation was performed on an Agilent MS‐HP5 column (30 m × 320 μm × 0.25 μm). The MS signal was obtained in the selected ion monitoring (SIM) mode. The method was validated according to the International Conference on Harmonization (ICH) guidelines. The accuracy of the method was measured via percentage recoveries of DMS from spiked α‐SME samples at spiking levels of (25, 125, 250, and 500) μg mL−1. The percentage recoveries for all spiking levels were found to be in the range of 88.6–97.4%. The repeatability and interday reproducibility were found to be satisfactory as the relative standard deviations (RSD) were within 11%. The method also has a good linear relationship as indicated by the coefficient of determination of 0.9996 over the range of 1.0–30 μg mL−1. The limits of detection (LOD) and quantification (LOQ) corresponded to 0.8 and 2.3 μg mL−1, respectively. The developed method demonstrated sufficient linearity, intraday and interday precision, sensitivity, and accuracy for determination of DMS in palm oil‐based α‐SME.
A 22‐37 GHz low noise amplifier with 2.8 dB mean noise figure and +22.9 dBm output 3rd‐order intercept point for 5th generation applications
Authors: Ma Qian , Xiang Yuanjiang 
Published: March 2019

AbstractThis paper presents a wideband 22‐37 GHz low noise amplifier (LNA) realized in a 0.25 μm SiGe BiCMOS technology. The design incorporates additional noise matching between the cascode transistors to minimize the noise figure (NF) degradation. The second stage incorporates an active balun architecture with a tail inductor to improve the common‐mode rejection ratio (CMRR). To extend the bandwidth, a capacitive feed forward path is added at the second stage. The LNA presents a minimum in‐band NF of 2.3 dB from 22‐37 GHz. The achieved 3 dB‐gain bandwidth is larger than 15 GHz, with a peak gain of 20.8 dB at 28 GHz. The output 3rd‐order intercept point (OIP3) is +22.9 dBm for a total power consumption of 94 mW. The area of the core circuit is 0.35 × 0.47 mm2. To the author's knowledge, the LNA shows the best overall performance compared to the existing silicon‐based LNAs.
A nonlinear Lagrangian particle model for grains assemblies including grain relative rotations
Authors: Turco Emilio , dell'Isola Francesco , Misra Anil 
Published: March 2019

SummaryWe formulate a discrete Lagrangian model for a set of interacting grains, which is purely elastic. The considered degrees of freedom for each grain include placement of barycenter and rotation. Further, we limit the study to the case of planar systems. A representative grain radius is introduced to express the deformation energy to be associated to relative displacements and rotations of interacting grains. We distinguish inter‐grains elongation/compression energy from inter‐grains shear and rotations energies, and we consider an exact finite kinematics in which grain rotations are independent of grain displacements. The equilibrium configurations of the grain assembly are calculated by minimization of deformation energy for selected imposed displacements and rotations at the boundaries. Behaviours of grain assemblies arranged in regular patterns, without and with defects, and similar mechanical properties are simulated. The values of shear, rotation, and compression elastic moduli are varied to investigate the shapes and thicknesses of the layers where deformation energy, relative displacement, and rotations are concentrated. It is found that these concentration bands are close to the boundaries and in correspondence of grain voids. The obtained results question the possibility of introducing a first gradient continuum models for granular media and justify the development of both numerical and theoretical methods for including frictional, plasticity, and damage phenomena in the proposed model.
Impact of personal bias on performance of employees in public sector banks
Authors: Wei Zhang , Siyal Abdul Waheed , Bhand Shaharbano 
Published: March 2019

PurposeThis study discusses the multitude of challenges that employees in public sector banks face regarding their annual performance appraisal due to personal bias exercised by their supervisors.Design/methodology/approachData were collected by interviewing 50 people working in five leading public sector banks in Pakistan to draw the outcomes of the present research.FindingsProblems lie in the implementation and justification of evaluation policies that affect employees' career growth, progression, and monetary rewards and fringes, which ultimately hit employees' annual performance appraisal. This study evidences the record deterioration in progression of employees due to personal bias as the appraisers give partial evaluations to those with whom they have any differences and favor their nears and dears or those who are more visible to them or remained in their good books due to personal reasons. This leads employees to feel unfairly treated because the evaluation criterion for performance appraisal seems unjust and illogical. This develops despair, distress, hostility, and distrust among employees when the appraisals are being conducted. The appraisal system does not differentiate between performers or nonperformers due to biased evaluations; therefore, decisions on promotions or career progression cannot be based on such appraisals. The problem of demotivation among employees is also a result of an ineffective performance appraisal mechanism, as no differentiation exists between star performers and nonperformers.Practical implicationsWhile considering the prevalent biased evaluation patterns in public sector banks, requisite changes in appraisal design need to be contemplated to rectify the process of performance appraisal and cope with employees' despair, hostility, and distrust.Originality/valueThe paper is an early attempt to investigate impact of supervisors' personal bias on employees' performance management, growth, and progression in public sector banks.
Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114
Authors: Xu Rong , Greening David W. , Chen Maoshan , Rai Alin , Ji Hong , Takahashi Nobuhiro , Simpson Richard J. 
Published: March 2019

AbstractExosomes are important bidirectional cell–cell communicators in normal and pathological physiology. Although exosomal surface membrane proteins (surfaceome) enable target cell recognition and are an attractive source of disease marker, they are poorly understood. Here, a comprehensive surfaceome analysis of exosomes secreted by the colorectal cancer cell line SW480 is described. Sodium carbonate extraction/Triton X‐114 phase separation and mild proteolysis (proteinase K, PK) of intact exosomes is used in combination with label‐free quantitative mass spectrometry to identify 1025 exosomal proteins of which 208 are predicted to be integral membrane proteins (IMPs) according to TOPCONS and GRAVY scores. Interrogation of UniProt database‐annotated proteins reveals 124 predicted peripherally‐associated membrane proteins (PMPs). Surprisingly, 108 RNA‐binding proteins (RBPs)/RNA nucleoproteins (RNPs) are found in the carbonate/Triton X‐114 insoluble fraction. Mild PK treatment of SW480‐GFP labeled exosomes reveal 58 proteolytically cleaved IMPs and 14 exoplasmic PMPs (e.g., CLU/GANAB/LGALS3BP). Interestingly, 18 RBPs/RNPs (e.g., EIF3L/RPL6) appear bound to the outer exosome surface since they are sensitive to PK proteolysis. The finding that outer surface‐localized miRNA Let‐7a‐5p is RNase A–resistant, but degraded by a combination of RNase A/PK treatment suggests exosomal miRNA species also reside on the outer surface of exosomes bound to RBPs/RNPs.
Profiling of Histidine Phosphoproteome in Danio rerio by TiO2 Enrichment
Authors: Gao Yan , Lee Hyojin , Kwon Oh Kwang , Cheng Zhongyi , Tan Minjia , Kim Ki‐Tae , Lee Sangkyu 
Published: March 2019

AbstractHistidine phosphorylation is a reversible post‐translational modification that is known to regulate signal transduction in prokaryotes. However, functional studies in eukaryotes have been largely neglected due to the labile nature of N‐linked phosphorylated amino acids. In an effort to help elucidate the heretofore hidden vertebrate phosphoproteome, this report presents a global phosphorylation analysis of Danio rerio (zebrafish) larvae. Phosphopeptide enrichment is performed using a TiO2 affinity technique. A total of 68 unique phosphohistidine sites are detected on 63 proteins among 1076 unique phosphosites on 708 proteins. Data are available via ProteomeXchange with identifier PXD012735. This report provides the first phosphohistidine dataset obtained from zebrafish.
Factors associated with depression over time in head and neck cancer patients: A systematic review
Authors: Korsten Laura H.A. , Jansen Femke , de Haan Ben J.F. , Sent Danielle , Cuijpers Pim , Leemans C. René , Verdonck‐de Leeuw Irma M. 
Published: March 2019

AbstractObjectiveTo systematically review the literature on factors associated with a clinical diagnosis of depression or symptoms of depression (depression) among head and neck cancer (HNC) patients.MethodsThe search was conducted in PubMed, PsycINFO, and CINAHL. Studies were included if they investigated factors associated with depression among HNC patients, they were of prospective or longitudinal nature, and English full text was available. The search, data extraction, and quality assessment were performed by two authors. Based on the data extraction and quality assessment, the level of evidence was determined.ResultsIn total, 35 studies were included: 21 on factors associated with depression at a single (later) time point, 10 on the course of depression, and four on both. In total, 77 sociodemographic, lifestyle, clinical, patient‐reported outcome measures, and inflammatory factors were extracted. Regarding depression at a single time point, there was strong evidence that depression at an earlier time point was significantly associated. For all other factors, evidence was inconclusive, although evidence suggests that age, marital status, education, ethnicity, hospital/region, sleep, smoking, alcohol, surgery, treatment, tumor location, and recurrence are not important associated factors. Regarding the course of depression, we found inconclusive evidence for all factors, although evidence suggests that gender, age, chemotherapy, pain, disease stage, treatment, and tumor location are not important associated factors.ConclusionDepression at an earlier time point is significantly associated with depression later on. Several sociodemographic and clinical factors seem not to be important factors associated with depression. For other factors, further research is warranted.
Clinical determinants for successful circulating tumor DNA analysis in prostate cancer
Authors: Schweizer Michael T. , Gulati Roman , Beightol Mallory , Konnick Eric Q. , Cheng Heather H. , Klemfuss Nola , De Sarkar Navonil , Yu Evan Y. , Montgomery R. Bruce , Nelson Peter S. , Pritchard Colin C. 
Published: March 2019

BackgroundPlasma‐based cell‐free DNA is an attractive biospecimen for assessing somatic mutations due to minimally‐invasive real‐time sampling. However, next generation sequencing (NGS) of cell‐free DNA (cfDNA) may not be appropriate for all patients with advanced prostate cancer (PC).MethodsBlood was obtained from advanced PC patients for plasma‐based sequencing. UW‐OncoPlex, a ∼2 Mb multi‐gene NGS panel performed in the CLIA/CAP environment, was optimized for detecting cfDNA mutations. Tumor tissue and germline samples were sequenced for comparative analyses. Multivariate logistic regression was performed to determine the clinical characteristic associated with the successful detection of somatic cfDNA alterations (ie detection of at least one clearly somatic PC mutation).ResultsPlasma for cfDNA sequencing was obtained from 93 PC patients along with tumor tissue (N = 67) and germline (N = 93) controls. We included data from 76 patients (72 prostate adenocarcinoma; 4 variant histology PC) in the analysis. Somatic DNA aberrations were detected in 34 cfDNA samples from patients with prostate adenocarcinoma. High PSA level, high tumor volume, and castration‐resistance were significantly associated with successful detection of somatic cfDNA alterations. Among samples with somatic mutations detected, the cfDNA assay detected 93/102 (91%) alterations found in tumor tissue, yielding a clustering‐corrected sensitivity of 92% (95% confidence interval 88‐97%). All germline pathogenic variants present in lymphocyte DNA were also detected in cfDNA (N = 12). Somatic mutations from cfDNA were detected in 30/33 (93%) instances when PSA was >10 ng/mL.ConclusionsDisease burden, including a PSA >10 ng/mL, is strongly associated with detecting somatic mutations from cfDNA specimens.
Controlling the isomerization dynamics of iodide acetonitrile dimer complex by optimally designed electromagnetic field: A wave packet based approach
Authors: Naskar Pulak , Talukder Srijeeta , Ghosh Subhasree , Chaudhury Pinaki 
Published: March 2019

AbstractBoth symmetric and asymmetric forms of the iodide acetonitrile dimer complex are known to exist with a higher stability shown by the symmetric isomer. Dynamics of this isomerization has been investigated on reduced dimensional surface in absence/presence of external electromagnetic field using Gaussian wave packet as the starting wave function. When the symmetric isomer has been taken as the initial structure, isomerization does not takes place without the external field due to high energy barrier, whereas with the asymmetric isomer as the starting one, isomerization takes place spontaneously with an equal population of both isomers. Our target in this study has been to get a dominant population of asymmetric isomer which is not possible without the application of electromagnetic field. However, it has also been seen that a simple monochromatic field cannot achieve this goal. Only by application of optimally designed polychromatic field the dominating population of asymmetric isomer can be obtained.
Shoot δ13C values as an indicator of cumulative stress: The role of re‐watering during drought and salinity stress
Authors: Sun Luan Zi , Liu Lu , Zhang Mengyu , Yang Liang , Guo Tongtian 
Published: March 2019

RationaleThe carbon stable isotope composition (δ13C value) of a plant can reflect prolonged drought and salinity, as different isotopic signals resulting from drought and salinity can be retained in plant tissue. Commonly, drought and salinity are interrupted by intermittent precipitation or irrigation. It remains unclear whether the δ13C values reflect the cumulative duration of intermittent drought or salinity stress.MethodsDrought (5% and 10% polyethylene glycol) and salinity (35 mM and 85 mM NaCl) were imposed on annual ryegrass consistently or cyclically; throughout the treatments, the stress duration for cyclic drought/salinity was half that of the corresponding prolonged stress treatment. The shoot δ13C values were measured using isotope ratio mass spectrometry.ResultsProlonged drought restrained growth and increased shoot δ13C values relative to the control group. However, the shoot biomass was even lower under cyclic drought than under prolonged drought. Furthermore, the shoot δ13C value under cyclic drought was close to that of the control group. The low NaCl concentration treatment actually enhanced shoot growth. The shoot δ13C value varied with both duration and intensity of salinity across all groups.ConclusionsThe shoot δ13C value in annual ryegrass did indicate cumulative stress from cyclic low salinity, but not that from cyclic drought, in a manner that was mediated by the effect of re‐watering on the mass and allocation of the photosynthates produced during stress.
Presence of benzotriazoles, benzothiazoles and benzenesulfonamides in surface water samples by liquid chromatography coupled to high‐resolution mass spectrometry
Authors: Hidalgo‐Serrano Míriam , Borrull Francesc , Marcé Rosa M. , Pocurull Eva 
Published: March 2019

AbstractAn analytical method has been developed for the simultaneous determination of seven benzotriazole, five benzothiazole and four benzenesulfonamide derivatives in surface water samples. The procedure is based on solid‐phase extraction with Oasis HLB, followed by high‐performance liquid chromatography coupled to high‐resolution mass spectrometry. Apparent recoveries ranged from 40 to 101%, except for compounds the matrix effect of which was above ‐60%. The repeatability (n = 5) of the method was below 20% for all compounds except 4‐hydroxybenzotriazole in river water. The method limits of detection for most compounds ranged from 1 to 12 ng/L for both river water and seawater. The method was then used for the determination of the studied compounds in several river water and seawater samples from harbour and coastal areas. 1‐H‐Benzotriazole (up to 78 ng/L in river water and above the upper limit of the calibration curve in seawater) and 4‐methyl‐1‐H‐benzotriazole (up to 44 ng/L in river water and 338 ng/L in seawater) were the most abundant compounds quantified in the samples, even though 5‐methyl‐1‐H‐benzotriazole and 2‐hydroxybenzothiazole were also found in most samples. Some compounds were frequently found in certain types of samples, such as 2‐aminobenzothiazole in river water. Benzenesulfonamide derivatives could not be quantified in any sample.
Finding Degradation Trigger Sites of Structural Materials for Airplanes Using X‐Ray Microscopy
Authors: Kimura Masao , Takeichi Yasuo , Watanabe Toshiki , Niwa Yasuhiro , Kimijima Ken'ichi 
Published: March 2019

AbstractMacroscopic properties of carbon fiber‐reinforced plastic (CFRP) and environmental barrier coating (EBC), widely used for airplanes, can be deteriorated by local cracks or degradation (“trigger sites”). We have tried to find these trigger sites using x‐ray microscopy (XM), which can provide the 2D or 3D images of the chemical states and microstructures. Crack initiation in CFRP was observed in a non‐destructive manner in multi‐scales (nm‐mm). 3D chemical‐state mapping of Yb in EBC was achieved with high resolution (<50 nm). In addition to XM, in‐situ observations at high temperatures were conducted for obtaining complementary information. X‐ray absorption spectroscopy (XAS) and x‐ray diffraction (XRD) analysis were performed simultaneously up to 1773 K. Dynamic XAS with short time‐resolution (<10 ns) was conducted to investigate changes in the local structure of metal. These approaches can help us identify degradation trigger sites in the materials.