bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 15-Year Bibliometric Analysis of Sports Medicine Studies in The Journal of Bone and Joint Surgery
Authors: Watters Amanda B , Blitz Jack , Mortell Tatjana , Ierulli Victoria K. , Lefante John , Mulcahey Mary K. 
Published: December 2024

Background:
Orthopaedic sports medicine is among the most popular subspecialties. Understanding the trends in sports medicine research over time can offer insight into progress and innovation within the field. The purpose of this study was to assess both the quality of the current literature and trends in gender diversity and inclusion by evaluating publishing characteristics of sports medicine studies in The Journal of Bone and Joint Surgery-American Volume (JBJS-A) from 2007 to 2021.

Methods:
Sports medicine studies in JBJS-A from 2007 to 2021 were identified using JBJS subspeciality tags for “sports medicine” articles and organized by study type, number of authors, sex of the authors, academic degree(s) of the first and last authors, level of evidence, country of publication, citations, and use of patient-reported outcomes (PROM).

Results:
A total of 784 studies were reviewed, and 513 met inclusion criteria. Clinical therapeutic studies were the most common publication (48%). There was an increase in the publication of clinical prognostic studies (17%-25%, p = 0.037) and a significant increase in the use of PROM measures over time (13%-47%, p < 0.001). The total number of authors increased over the study period (4.8-6.3), but there was no significant increase in female authorship. Only 15% of the 784 studies included a female author, with an average of 0.8 female authors per article (range 0-8) compared with 4.6 males (range 1-14).

Conclusion:
The significant increase in the use of PROMs in sports medicine studies indicates that the quality of research has improved over the 15-year period. The gender disparity in authorship has remained stagnant. Only 11% of all first authors and 9% of senior authors were female. The number of included international studies improved over time; however, the United States remains the most prolific publisher. Despite these areas of growth, this study suggests that there is room for improvement of authorship gender diversity in orthopaedic sports medicine research.

Level of Evidence:

Level III. See Instructions for Authors for a complete description of levels of evidence.
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
Authors: Castellano Esther , Rosell Alejandro , Krygowska Agata , Alcón Marta Alcón Pérez , Cuesta Cristina , Voisin Mathieu-Benoit , de Paz Juan , Sanz-Fraile Héctor , Rajeeve Vinothini , Berral-González Alberto , Carreras-González Ana , Swinyard Ottilie , Gabandé-Rodriguez Enrique , Downward Julian , Alcaraz Jordi , Anguita Juan , García-Macías Carmen , Rivas Javier De Las , Cutillas Pedro 
Published: December 2024

Abstract

Macrophages are crucial in the body's inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS-p110α signalling pathway, known for its involvement in various biological processes and tumorigenesis, regulates two vital aspects of the inflammatory response in macrophages: the initial monocyte movement and later-stage lysosomal function. Disrupting this pathway, either in a mouse model or through drug intervention, hampers the inflammatory response, leading to delayed resolution and the development of more severe acute inflammatory reactions in live models. This discovery uncovers a previously unknown role of the p110α isoform in immune regulation within macrophages, offering insight into the complex mechanisms governing their function during inflammation and opening new avenues for modulating inflammatory responses.
Polyacetylene formation under simulated circumstellar conditions
Authors: Shi Zaifa , Wu Di , Li Yunkai , Ying Haotian , Cui Cunhao , Lin Shuichao , Zheng Lan-Sun 
Published: December 2024

Abstract

Carbon-chain molecules serve as precursors for complex molecules in the interstellar medium and act as indicators of both current physical conditions and past evolutionary trends. They hold significant importance in interstellar chemistry. Although typical carbon-chain molecules like polyacetylene (C4H2, C6H2) have been observed in the IRC + 10216 star and CRL618 nebula, the formation mechanism of longer carbon-chain polyacetylenes remains under investigation. The development of an ultra-high-temperature pyrolysis photoionization time-of-flight mass spectrometer (UT-Py-PI-TOFMS) in laboratory astrophysics simulation experiments provides insights into the formation process of interstellar molecules. Detection of a range of long-chain polyacetylene molecules (up to 16 carbon atoms) in this instrument indicates that rapid radical reactions of •C2nH with unsaturated hydrocarbons govern the growth process of long-chain polyacetylenes. These findings offer compelling evidence for the formation of carbon-chain molecules in space. Furthermore, this experiment successfully reproduces other interstellar molecules such as fullerenes.
Salinity tolerance in Cucumis sativus seedling: the role of pistachio wood vinegar on the improvement of the vigor seedling
Authors: Afsharipour Sediqeh , Seyedi Azam , Dastjerdi Abdolmajid Mirzaalian 
Published: December 2024

Abstract

Background
Soil salinity is a major environmental concern that affects the production of salt-sensitive crops such as cucumbers by limiting their growth and development. Due to its beneficial effects on plants, wood vinegar is now used as a biostimulant in agriculture to enhance crop productivity and improve the plants defense system against pathogens, while studies show that it can also protect against oxidative stresses. A pot experiment was carried out to mitigate the negative effects of sodium chloride (NaCl) on cucumber seedlings through pistachio wood vinegar (PWV) foliar spraying. Were assessed for their growth after exposure to intense salinity stress (150 mM NaCl) in compared to control (0 mM NaCl) and three levels of PWV (0, 1500, and 3000 PPM) as the foliar spraying. The experiment was arranged as a randomized complete block design (RCBD) with three replicates.
Results
The intense salinity stress reduced the fresh and dry mass of root and shoot by 25, 5, 34, and 13%, and decreased chlorophyll a, b, total, and carotenoids by 14, 45, 28, and 44%, respectively compared to the control. Also, in the treated plants with PWV decreased levels of non-enzymatic antioxidants i.e. total protein (14%), and anthocyanin (17%). While PWV treatment decreased the negative effects of the intense salinity stress and enhanced the fresh mass root (41%), dry mass shoot (33%), shoot length (23%), leaf area (34%), number of leaves (63%), Chl a (14%), Chl b (11%) and carotenoids (56%). Under the intense salinity stress, the foliar spraying of PWV, 3000 ppm, decreased the reactive oxygen species (ROS) and malondialdehyde (MDA) by 7 and 10%, respectively compared to the control.
Conclusions
This study shows that the use of PWV (1500 ppm) is effective in improving the negative effects of extreme salinity in cucumber seedlings.
A versatile gold leaf immunosensor with a novel functionalization strategy based on Protein L and Trastuzumab-modified surface for efficient HER2 detection
Authors: Kundacina Ivana , Schobesberger Silvia , Kittler Stefan , Thumfart Helena , Spadiut Oliver , Ertl Peter , Knezevic Nikola , Radonic Vasa 
Published: December 2024

Abstract

Although various sensors specifically developed for target analytes are available, affordable biosensing solutions with broad applicability are limited. In this study, a cost-effective biosensor for detecting human epidermal growth factor receptor 2 (HER2) was developed using custom-made gold leaf electrodes (GLEs). A novel strategy for antibody immobilization on a gold surface, for the first time mediated by protein L and HER2-specific antibody trastuzumab, was examined using commercial screen-printed gold electrodes and GLEs. A self-assembled monolayer of 11-mercaptoundecanoic acid (MUA) was formed on the gold surface, which was used to covalently immobilize protein L. Further binding of trastuzumab to the protein L was employed and HER2 detection was achieved through electrochemical impedance spectroscopy (EIS). The HER2 detection was examined in phosphate-buffered saline (PBS) and supplemented cell culture medium. The modified GLEs showed good specificity and high sensitivity of HER2 detection without any enrichment steps, achieving a limit of detection (LOD) of 0.02 ng mL− 1 in PBS and 0.03 ng mL− 1 in cell culture medium, making the proposed immunosensor a cost-effective and sensitive solution for detection in complex biological matrices.
Structural Design, Analysis and Testing of 3D Water Phantom for Proton Therapy
Authors: Liu Xinzhi , Wang Kaisong , Wei Jianghua , Hong Liang , Lan Bin , Guo Zhoushun 
Published: December 2024

Abstract

Proton therapy is an advanced radiation therapy technique that allows for precise treatment of the tumor site. 3D water phantom system is the important testing equipment for proton therapy,which can guarantee the dose before treatment, realize dose distribution scanning detection. It includes a lifting platform, a high-precision three-dimensional servo, ionization chambers, a control system and a water tank. The lifting platform and high-precision three-dimensional servo are the key factors which can affect the accuracy of proton beam measurement. The 3D water phantom structure design is carried out to realize proton beam dose detection. Finite element analysis model is established to carry out mechanical mechanics analysis of the 3D water phantom structure. During scanning detection, the vibration generated by the servo motor operation may cause the 3D water phantom structure resonance, carry out modal analysis and harmonic response analysis, calculate the 3D water phantom intrinsic frequency and motor operation vibration frequency within the possible resonance intervals. In addition, the 3D water phantom model was utilized to carry out Bragg peak detection experiments at different energies for proton therapy.
Efficacy of Intraoperative Radio frequency Ablation in Patients Undergoing Mitral Valve Replacement for Rheumatic Heart Disease Complicated by Chronic Atrial Fibrillation.
Authors: Ahrar Naiem , Kangoo Abid , Bashir Shahbaz , Khurshid Sheikh mudassir , Ganie Farooq A , Hakeem Zubair Ashraf , Majeed Souliyh 
Published: December 2024

Abstract

Background Atrial fibrillation (AF) is a common arrhythmia, especially prevalent among patients with rheumatic heart disease (RHD). The presence of AF in these patients significantly exacerbates the risk of thromboembolic events and heart failure. This study evaluates the efficacy of intraoperative Radio frequency ablation (RFA) performed concomitantly with mitral valve replacement (MVR) in patients with RHD complicated by chronic AF.Results Twenty patients with permanent AF and mitral valve disease underwent MVR with concomitant RF ablation. Outcomes measured included conversion to sinus rhythm, left ventricular ejection fraction (LVEF), left atrial (LA) size, antiarrhythmic burden, and quality of life. At one year post-operation, 95% of patients had converted to sinus rhythm. Mean LVEF improved from 46.00% preoperatively to 52.25% postoperatively. LA size decreased significantly from a mean of 55.25 mm to 45.75 mm. Antiarrhythmic burden decreased by 50% in 85% of patients. No mortality was observed.Conclusion Intraoperative RF ablation concomitant with MVR is a safe and effective procedure for patients with RHD and chronic AF, resulting in high rates of sinus rhythm conversion, improved cardiac function, and reduced antiarrhythmic burden.
The Gly482Ser PPARGC1A polymorphism regulates PGC-1α stability and human brown adipocyte mitochondrial function under cold exposure
Authors: Kalamajski Sebastian , Huang Mi , Baira Shandilya , Coral Daniel , Spégel Peter , Claussnitzer Melina , Mulder Hindrik , Franks Paul 
Published: December 2024

Abstract

Adaptive thermogenesis in brown adipose tissue is regulated by PPARGC1A (PGC-1α), which could be affected by common polymorphism (rs8192678, Gly482Ser) that associates with metabolic disorders. We used CRISPR-Cas9 in immortalized human brown adipocyte cell line to edit the rs8192678 locus to evaluate the allele-dependent effects on cold response of brown adipocytes. In both 482Ser- and 482Gly-edited brown adipocytes, UCP1 expression increased after 6-hour cold exposure, but the increase was less pronounced in 482Gly cells, which also had lower mitochondrial activity. Furthermore, 482Gly PGC-1α had an almost two-fold longer half-life at 37°C, and four-fold longer half-life at 32°C, compared with the 482Ser variant. Despite the longer half-life, the 482Gly PGC-1α had lower activity, and was more prone to be retained in the cytoplasm after cold exposure. Our experimental data support gene x environment interactions between Gly482Ser and cold exposure in human brown adipocytes. These data support a novel molecular basis for the epidemiological observations that link the Gly482Ser polymorphism with obesity and related metabolic disorders.
Digital Skills and Recreational Behaviour Across Generations: Implications for Visitor Management in Forest Destinations – Case Study of Vienna Metropolitan Area, Austria
Authors: Stefán Fruzsina , Ciesielski Mariusz , Weber Andy , Choromański Kamil , Gotlib Dariusz , Taczanowska Karolina 
Published: December 2024

Abstract

Digitalization significantly impacts human-environment systems by altering how people interact with natural spaces. This extends to outdoor recreation, where digital tools increasingly serve as interfaces between visitors and site management authorities. However, to date, little attention has been given to the digital divide across generations within this application domain. Therefore, this study investigates the generational differences in digital skills and recreational behaviour and highlights its implications for visitor management in urban and suburban forest destinations. Using data from an online panel of 3,121 respondents in Vienna, we examined how digital competence influences outdoor recreation across age groups. The results highlight significant differences in technology use when planning and navigating during leisure trips between generations. Four major visitor profiles have been identified, each reflecting distinct patterns of digital tool usage and recreational preferences and corresponding with the respondents’ age. We emphasize the need for inclusive and adaptive management strategies to accommodate diverse digital behaviours and enhance urban forest experiences for all generations. Recognizing that effective management is contingent on understanding the nuances of technology utilization, our case study-based approach seeks to understand the public's demand for nature and the contribution of forest areas to recreation, through the lens of different generations.
Efficacy of percutaneous vertebroplasty in the treatment of severe osteoporotic vertebral compression fractures
Authors: Zhang Feng , Gao Hao-Ran , Fu Hao , Li Duo-Hua , Zhao Si-Cong , Zhou Cheng-Qiang , Gao Xiao , Wu Dong-Ying , Feng Hu , Yuan Feng , Sun Wei 
Published: December 2024

Abstract

Background: Percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) are two minimally invasive surgical procedures and have achieved satisfactory outcomes in the treatment of mild to moderate osteoporotic vertebral compression fractures (OVCF) .However, severe osteoporotic vertebral compression fractures (sOVCF),used to been regarded as relative or even absolute contraindication for PVP and PKP.To date, there is still no consensus on the optimal treatment strategy for sOVCF.
Methods: A retrospective analysis was conducted on 37 patients (7 males and 30 females) with single-level sOVCF who underwent PVP surgery at the Affiliated Hospital from May 2019 to May 2022. The age of the patients ranged from 61 to 88 years (average, 74.16 ± 7.76 years). The height and height ratio of the injured vertebra and the local kyphotic angle (LKA) were compared before and after surgery. The visual analog scale (VAS) and Oswestry Disability Index (ODI) were used to evaluate the clinical efficacy of the surgery and the improvement in patients' quality of life. Operative time, bone cement volume, complications, and adjacent vertebral fractures were also analyzed.
Results: All patients successfully underwent surgery and were followed up for an average of 24.2 months. The height of the fractured vertebrae recovered from 5.79 ± 1.94 mm preoperatively to 14.21 ±3.72 mm at the final follow-up (P<0.05). The height ratio of the fractured vertebrae recovered from 22.79 ± 7.40% preoperatively to 56.10 ± 14.69%at the final follow-up (P<0.05). The LKA improved from 25.63° ± 12.96° preoperatively to 22.48° ± 12.06° at the final follow-up (P<0.05). The VAS and ODI scores decreased from 6.46 ± 1.30％ and 77.51 ± 4.38％preoperatively to 2.57 ± 1.24％ and 25.57 ± 3.24％ at the final follow-up, respectively(P<0.05). Cement leakage occurred in seven patients. Adjacent OVCF occurred in four patients.
Conclusions: PVP proves to be a safe, cost-effective and minimally invasive alternative therapy for elderly patients with sOVCF that can restore the vertebral height and correct local kyphosis in properly selected patients.
Human need satisfaction enables decoupling of well-being from income
Authors: Tamberg Lea , Steinberger Julia , Cologna Viktoria , Fisch-Romito Vivien , Millward-Hopkins Joel , Calvo Flavio , Oreskes Naomi 
Published: December 2024

Abstract

Understanding the link between well-being and income is crucial for assessing the viability of sustainability strategies that limit affluence. Here, we examine the extent to which the satisfaction of basic human needs can explain the correlation between income and life evaluation, an indicator of subjective well-being. Using more than 1.3 million responses from the Gallup World Poll, we estimate the effect of absolute and relative income, GDP per capita, and GDP growth on life evaluation, while controlling for individual and country-level need satisfaction, and governance quality. We find that a hypothetical country achieving population-wide need satisfaction would, even at a GDP per capita of $10,000, match today’s happiest countries in terms of life evaluation. Beyond this income level, the remaining effects of absolute income are marginal. Our results suggest that basic human needs play a central role in decoupling subjective well-being from economic growth.
Using Prefrontal EEG-Derived Theta Cordance to Predict the Response to Anodal Transcranial Direct Current Stimulation (atDCS) in Female Patients with Treatment-Resistant Depression
Authors: Hosseini Seyed Ruhollah , Roghieh Nooripour , Ghanbari Nikzad 
Published: December 2024

Abstract

Background: In this study, we investigated how theta cordance patterns from the prefrontal (PF), midline left (MLF), and midline right frontal (MRF) cortex can predict the effectiveness of Anodal Transcranial Direct Current Stimulation (atDCS) in treating female patients with Treatment-Resistant Depression (TRD).
Methods: Our quasi-experimental design included 30 women with TRD, whom we evaluated at the start, after one week (post seven tDCS sessions), and after two weeks (post 14 sessions). The participants were selected through the Structured Clinical Interview for DSM-V-Clinical Version and assessed their depressive symptoms and brain electrical activity using Beck's Depression Inventory II (BDI-II) and electroencephalography (EEG). We identified early responders and non-responders after one week based on a decrease of at least 30% in their BDI scores from baseline, ensuring blinded assessments.
Results: Our findings revealed a significant decrease in PF and MLF cordance after one week of tDCS, while changes in MRF cordance were not significant. Notably, MRF cordance changes emerged as a potential predictor of early tDCS response when compared to BDI scores, PF, and MLF cordance. By integrating changes in theta cordance and BDI scores from baseline to the first week (ΔBDI+ΔPF, ΔBDI+ΔMRF, ΔBDI+ΔMLF), we developed predictive models that were statistically significant. The ΔBDI+ΔMLF model showed the highest significance, suggesting it may be a superior predictor of treatment response.
Conclusions: Our study highlights the potential of combining EEG-derived theta cordance from different frontal regions with symptom-based assessments to predict early responses to tDCS in female patients with TRD. These findings underscore the value of precise and tailored interventions in the treatment of treatment-resistant depression.
Analysis of planetary boundaries for waste valorization in the biorefinery context: Case study of the corn value chain in Sucre, Colombia
Authors: Hernandez-Arango Juan Felipe , Ortiz-Sanchez Mariana , Solarte-Toro Juan Camilo , Salcedo-Mendoza Jairo , Cardona-Alzate Carlos Ariel 
Published: December 2024

Abstract

The environmental impact generated by the excessive use of energy and petrochemical products has become a current problem addressed by considering the valorization of waste from a Value Chain (VC) under the biorefinery concept. At a global level, international organizations have proposed different tools to control the environmental impact of VC. the Life Cycle Analysis (LCA) is the most representative tool. However, the LCA results do not allow defining a VC impact in a territory. The Planetary Boundaries (PB) approach contextualizes the results of an LCA with the maximum limits allowed for a defined activity. This research aimed to propose and apply a methodology integrating the LCA and PB approach (PBA-LCA). For this, waste valorization under the biorefinery concept was considered. The conceptual process analysis, economic optimization of biorefineries, LCA, and PB approach tools were combined and applied to a representative case study (the corn VC in Sucre, Colombia). First, the corn VC was analyzed to define different valorization alternatives for Corn Stover (CS). The valorization alternatives were simulated and evaluated using Aspen Plus V9.0., and Aspen Economic Analyzer V9.0. and SimaPro V8.3. The LCA impact categories were used to define the PB. The economic optimization of CS biorefineries resulted in the technical and economic limitations of the cellulose valorization fraction due to high capital and operating costs. The LCA results demonstrated the advantages of using CS in agricultural activities. In the biorefinery, the split of CS scenarios for biorefineries had a higher environmental impact. Finally, the PB results demonstrated the advantage of the CS current use. On the other hand, the PB analysis determined the appropriate split of CS scenario to be implemented in Sucre, Colombia. In conclusion, the results demonstrated the need to contextualize the results of an LCA with the PB in a given region to analyze the processes environmental viability.