bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical stress contributes to osteoarthritis development through the activation of transforming growth factor beta 1 (TGF-β1)
Authors: Zhang R-K. , Li G-W. , Zeng C. , Lin C-X. , Huang L-S. , Huang G-X. , Zhao C. , Feng S-Y. , Fang H. 
Published: November 2018

Objectives The role of mechanical stress and transforming growth factor beta 1 (TGF-β1) is important in the initiation and progression of osteoarthritis (OA). However, the underlying molecular mechanisms are not clearly known. Methods In this study, TGF-β1 from osteoclasts and knee joints were analyzed using a co-cultured cell model and an OA rat model, respectively. Five patients with a femoral neck fracture (four female and one male, mean 73.4 years (68 to 79)) were recruited between January 2015 and December 2015. Results showed that TGF-β1 was significantly upregulated in osteoclasts by cyclic loading in a time- and dose-dependent mode. The osteoclasts were subjected to cyclic loading before being co-cultured with chondrocytes for 24 hours. Results A significant decrease in the survival rate of co-cultured chondrocytes was found. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling (TUNEL) assay demonstrated that mechanical stress-induced apoptosis occurred significantly in co-cultured chondrocytes but administration of the TGF-β1 receptor inhibitor, SB-505124, can significantly reverse these effects. Abdominal administration of SB-505124 can attenuate markedly articular cartilage degradation in OA rats. Conclusion Mechanical stress-induced overexpression of TGF-β1 from osteoclasts is responsible for chondrocyte apoptosis and cartilage degeneration in OA. Administration of a TGF-β1 inhibitor can inhibit articular cartilage degradation. Cite this article: R-K. Zhang, G-W. Li, C. Zeng, C-X. Lin, L-S. Huang, G-X. Huang, C. Zhao, S-Y. Feng, H. Fang. Mechanical stress contributes to osteoarthritis development through the activation of transforming growth factor beta 1 (TGF-β1). Bone Joint Res 2018;7:587–594. DOI: 10.1302/2046-3758.711.BJR-2018-0057.R1.
Pupils’ Questions in Dialogic Teaching from the Perspective of Pedagogical Research
Authors: Lukášová Hana , Pavelková Marie 
Published: November 2018

Abstract
Introduction: In our conditions and in the world, there is a tradition of the sequence of sequential communication exchanges in the interaction of a teacher and pupils, which was examined in the analysis of the processes and structures in educational communication. This tradition can be continued from the perspective of research at the 1st stage of elementary school education. Purpose: The aim of the study is to present the findings of a research on the issues of pupils’ questions. The research question is whether the existing results of educational research on the educational interaction and teacher-student communication in the educational process at the first stage of elementary schools also capture the characteristics of pupils’ questions. We will investigate the perception of dialogic teaching and pupils’ question in educational research. The sequence of sequential communication exchanges in the interaction between teachers and pupils, which was examined in the analysis of the processes and structures of educational communication, has in our country and in the world a tradition which can be followed in terms of research on teaching at the first stage of primary schools. One of the aspects of research on the interaction and communication in the classroom are the views of teachers who are discovering what a learner knows, and what he/she thinks about the communicated content and curriculum. But we are mainly interested in the results of educational research from the perspective of the pupil and his/her questions in the classroom. Methods: In our research, our intention was to analyse pupils’ questions which are to supplement their knowledge, or to find out more information that would help them deal with learning tasks. We were interested in previous investigations and were seeking for clarification whether the pupils’ questions are inconsistent, which would reveal misconceptions and wrong ideas in the understanding of the teaching content. Conclusions: The most frequently, pupils’ answer to the teacher’s questions were detected. The conclusions show the current results of pedagogical research in the context of dialogic teaching, they do not capture the characteristics of pupils’ questions in teaching at the 1st grade of elementary schools.
Nanoparticles as carriers of proteins, peptides and other therapeutic molecules
Authors: Pudlarz Agnieszka , Szemraj Janusz 
Published: November 2018

AbstractNanoparticles have many applications both in industry and medicine. Depending upon their physical and chemical properties, they can be used as carriers of therapeutic molecules or as therapeutics. Nanoparticles are made of synthetic or natural polymers, lipids or metals. Their use allows for faster transport to the place of action, thus prolonging its presence in the body and limiting side effects. In addition, the use of such a drug delivery system protects the drug from rapid disintegration and elimination from the body. In recent years, the use of proteins and peptides as therapeutic molecules has grown significantly. Unfortunately, proteins are subject to enzymatic digestion and can cause unwanted immune response beyond therapeutic action. The use of drug carriers can minimize undesirable side effects and reduce the dose of medication needed to achieve the therapeutic effect. The current study presents the use of several selected drug delivery systems for the delivery of proteins, peptides and other therapeutic molecules.
A novel TNNI3 gene mutation (c.235C>T/ p.Arg79Cys) found in a thirty-eight-year-old women with hypertrophic cardiomyopathy
Authors: Tao Qin , Yang Junhua , Cheng Weili , Yu Shenghua , Fang Xu , He Pingping , Zhang Yuqing 
Published: November 2018

AbstractWe report the case of a thirty-eight-year-old woman admitted to our hospital due to palpitation and chest distress. ST-T segment change was found in her ECG. She was then diagnosed with hypertrophic cardiomyopathy by two-dimensional echocardiography. Physical examination showed no obvious abnormal signs and all laboratory examinations were within the normal range. Myocardial fibrosis was detected by cardiac magnetic resonance imaging (MRI). A novel heterozygous mutation (c.235C>T/p.Arg79Cys) in TNNI3 for cardiac troponin I was identified in her. Subsequently, her families were investigated. No one died suddenly in her family. Her father, one of her siblings and one of her daughters had the same genetic mutation but with different clinical manifestations while the others were healthy. Her father and brother were also diagnosed with hypertrophic cardiomyopathy with different clinical manifestation. However, the echocardiography of her daughter was absolutely normal. We hypothesized that the Arg79Cys mutation in TNNI3 leads to a slow development of cardiac hypertrophy and the phenotype of this gene mutation is diverse.
Oganesson, Where Art Thou?
Authors: Rabinovich Daniel 
Published: November 2018

Abstract
In a press release dated 30 December 2015, the International Union of Pure and Applied Chemistry (IUPAC) announced that a thorough review by independent experts of the experimental data available for the syntheses of elements 113, 115, 117, and 118 has been concluded, and that the discovery of the four elements completing the 7th row of the periodic table was confirmed. The elemental names and symbols proposed shortly thereafter by the corresponding discovery teams met the criteria prescribed by IUPAC for naming new elements, and nihonium (Nh), moscovium (Mc), tennessine (Ts), and oganesson (Og), became permanent within a few months. As such, the ending of the name of element 118 and its location in the periodic table, below radon in group 18, are consistent with the assumption that oganesson could be regarded as a noble gas.
Fuzzy Logic Based Control Scheme for Doubly Fed Induction Generator Based Wind Turbine
Authors: Bhukya Jawaharlal , Mahajan Vasundhara 
Published: November 2018

Abstract
Stator Flux Orientation Control Scheme (SFOCS) has limitations that its performance is mainly influenced by the tuning of parameters, the Proportional-Integral (PI) controller could not compensate system variations very efficiently. To overcome the drawbacks of PI controller the Fuzzy Logic Controllers (FLCs) are modelled. This paper presents the fuzzy logic based control strategy for the variable speed wind turbine generator by using Doubly Fed Induction Generator (DFIG). The mathematical model for DFIG is developed in synchronous reference frame by using SFOCS for current and voltage control and is discretized in time domain. Based on this model the artificial intelligence based FLCs are designed and implemented so as to improve the performance and efficiency of the system. This control scheme not only enhances the dynamic performance but also maintains almost unity power factor to the grid. In order to explore the robustness of the FLC and conventional PI controller, simulations are carried out for rapid variation of wind speed, and different disturbances generated in the system. The simulation results show that the proposed fuzzy logic based control strategies have better power control, faster oscillation damping, more accurate regulation, considerably reduced settling time and has fewer ripples in comparison with conventional PI controller. In the proposed SFOCS, the PI controllers are replaced with FLCs, to improve the performance and efficiency of the system. The system performance is analyzed for real and reactive power control in SFOCS for the effectiveness of synchronization with the grid.
An efficient preconditioning method for state box-constrained optimal control problems
Authors: Axelsson Owe , Neytcheva Maya , Ström Anders 
Published: November 2018

Abstract
An efficient preconditioning technique used earlier for two-by-two block matrix systems with square matrix blocks is shown to be applicable also for a state variable box-constrained optimal control problem. The problem is penalized by a standard regularization term for the control variable and for the box-constraint, using a Moreau–Yosida penalization method. It is shown that there occur very few nonlinear iteration steps and also few iterations to solve the arising linearized equations on the fine mesh. This holds for a wide range of the penalization and discretization parameters. The arising nonlinearity can be handled with a hybrid nonlinear-linear procedure that raises the computational efficiency of the overall solution method.
Numerical simulation of aberrated medical ultrasound signals
Authors: Beklemysheva Katerina A. , Grigoriev Georgiy K. , Kulberg Nikolay S. , Petrov Igor B. , Vasyukov Aleksey V. , Vassilevski Yuri V. 
Published: November 2018

Abstract
Transcranial ultrasound examination is hampered by the skull which acts as an irregular aberrator of the ultrasound signal. Numerical recovery of the ultrasound field can help in elimination of aberrations induced by the skull. In this paper, we address the simulation of medical phantom scanning through silicon aberrators with wave notching. The numerical model is based on the 2D acoustic equations which are solved by the wavefront construction raytracing method. Numerical B-scan images are compared with experimental B-scan images.
Neutral Axis in Thermally Modified Timber Determined by Image-Based Approach
Authors: Brabec Martin , Milch Jaromír , Čermák Petr , Děcký David , Sebera Václav , Tippner Jan 
Published: November 2018

Abstract
An alternative assessment procedure for the mechanical performance of thermally modified timber is presented. Non-defect beech wood (Fagus sylvatica L.) specimens were thermally modified at 180°C and 200°C and subjected to static three-point bending load. Based on the full-field strain data acquired during the tests, the neutral axis (NA) at a 50 % level of maximal loading force was identified and localized within the specimen height by means of image processing methods. The NA in specimens mildly thermally modified moved toward the tensile zone when compared to the control specimens, whereas the position of NA within the specimens severely thermally modified was comparable with the NA position in control specimens. The proposed procedure proved to be applicable for the assessment of the mechanical performance; however, in the present study, the NA movements caused by thermal modification were not found to be statistically significant.
Design and Characterization of Secondary and Tertiary Layers of a Multilayer Wound Dressing System
Authors: Kubera Sampath Kumar S. , Prakash C. , Vaidheeswaran S. , Karthic Kumar B. , Subramanian S. 
Published: November 2018

Abstract
A nonwoven secondary layer was produced from silk fibroin by a compression and spunlacing method. Super absorbent polymer (SAP) was added to the nonwoven mat to increase the exudates and absorption capacity and manage the moisture in the wound site. Three types of tertiary layers, viz., cotton gauze cloth, adhesive tape, and polyurethane film, were experimented on for the properties that are essential for those layers. The structural stability was found to be better in the spunlaced nonwoven compared to the compressed nonwoven. The Phosphate Buffer Saline (PBS) absorption of the nonwoven increased with an increase in the concentration of SAP percentage. The PBS absorption was found to be lower for the spunlaced nonwoven because of the higher fiber entanglement and packing compared to that of the compressed nonwoven. The vapor permeation rate (grams per square meter a day) across the nonwoven mat decreased with an increase in grams per square meter, and there was no effect from the SAP percentage added to the nonwoven mats. Horizontal and vertical wicking of the spunlaced nonwoven was better than that of the compressed nonwoven. The results showed that spunlaced nonwoven would be a better material for the secondary layer. The vapor transmission rate was highest for cotton gauze cloth, followed by adhesive tape and film. The multilayer wound-dressing system consisting of primary, secondary, and tertiary layers was tested for PBS vapor transmission rate and bacterial penetration. The results showed that the wound-dressing system made from film and adhesive tape did not allow the Staphylococcus aureus bacterial culture to penetrate through the wound-dressing system.
Psychological effects of dopamine agonist treatment in patients with hyperprolactinemia and prolactin-secreting adenomas
Authors: Ioachimescu Adriana G , Fleseriu Maria , Hoffman Andrew R , Vaughan III T Brooks , Katznelson Laurence 
Published: November 2018

Background
Dopamine agonists (DAs) are the main treatment for patients with hyperprolactinemia and prolactinomas. Recently, an increasing number of reports emphasized DAs’ psychological side effects, either de novo or as exacerbations of prior psychiatric disease.

Methods
Review of prospective and retrospective studies (PubMed 1976, September 2018) evaluating the psychological profile of DA-treated patients with hyperprolactinemia and prolactinomas. Case series and case reports of psychiatric complications were also reviewed.

Results
Most studies were cross-sectional and had a control group of healthy volunteers or patients with nonfunctioning pituitary adenomas. There were few prospective studies, with/without control group, that included small numbers of patients. Compared with controls, patients with hyperprolactinemia generally had worse quality of life, anxiety, depression and certain personality traits. Patients receiving DAs had higher impulsivity scores than normoprolactinemic controls. Impulse control disorders (ICDs) were reported in both genders, with hypersexuality mostly in men. Multiple ICDs were sometimes reported in the same patient, usually reversible after DA discontinuation. In case reports, DA therapy was temporally associated with severe depression, manic episodes or psychosis, which improved after discontinuation and administration of psychiatric medications. Gender type of DA, dose and duration of therapy did not correlate with occurrence of psychiatric pathology.

Conclusion
Patients with hyperprolactinemia receiving DAs may develop changes in mood and behavior regardless of prior psychiatric history. Increased awareness for ICDs, depression, mania and other types of psychosis is needed by all physicians who prescribe DAs. Larger prospective controlled clinical studies are needed to delineate prevalence, risk stratification and management.
Prevalence of moderate-to-severe TR suitable for percutaneous intervention in TTE patients
Authors: Teoh Z. H. , Roy J. , Reiken J. , Papitsas M. , Byrne J. , Monaghan M. J. 
Published: November 2018

Abstract
Moderate-to-severe tricuspid regurgitation is associated with higher mortality and morbidity yet remains significantly undertreated. The reasons for this are complex but include a higher operative mortality for patients undergoing isolated tricuspid valve surgery. This study sought to determine the prevalence of patients with moderate-tosevere tricuspid regurgitation and identify those who could be potentially suitable for percutaneous tricuspid valve intervention by screening patients referred for transthoracic echocardiography (ECHO) at a tertiary center. Our results showed that the prevalence of moderate-to-severe tricuspid regurgitation in our total ECHO patient population was 2.8%. Of these, approximately one in eight patients with moderate-to-severe tricuspid regurgitation would be potentially suitable for percutaneous intervention and suggests a large, unmet clinical need in this population.
vqtl: An R Package for Mean-Variance QTL Mapping
Authors: Corty Robert W , Valdar William 
Published: November 2018

Abstract
We present vqtl, an R package for mean-variance QTL mapping. This QTL mapping approach tests for genetic loci that influence the mean of the phenotype, termed mean QTL, the variance of the phenotype, termed variance QTL, or some combination of the two, termed mean-variance QTL. It is unique in its ability to correct for variance heterogeneity arising not only from the QTL itself but also from nuisance factors, such as sex, batch, or housing. This package provides functions to conduct genome scans, run permutations to assess the statistical significance, and make informative plots to communicate results. Because it is inter-operable with the popular qtl package and uses many of the same data structures and input patterns, it will be straightforward for geneticists to analyze future experiments with vqtl as well as re-analyze past experiments, possibly discovering new QTL.
Clinical Risk Factors for Revisits for Children With Community-Acquired Pneumonia
Authors: Ambroggio Lilliam , Herman Helena , Fain Emily , Huang Guixia , Florin Todd A. 
Published: November 2018

BACKGROUND:
Children discharged from the emergency department (ED) with community-acquired pneumonia (CAP) revisit for several reasons, including disease progression or treatment failure. Understanding factors associated with revisits may assist clinicians in preventing subsequent visits.

METHODS:
Children aged 3 months to 18 years with an International Classification of Diseases, Ninth Revision diagnosis of CAP between December 1, 2009 and April 31, 2013 were eligible. The primary outcome was a CAP-related ED visit or hospitalization within 30 days of the index visit. The secondary outcome was a CAP-related ED visit within 48 hours of discharge from the index visit. The association between clinical variables and an ED revisit for children with CAP was assessed by using multivariable logistic regression models.

RESULTS:
Of the 3304 index ED visits by patients with CAP, 148 (4.5%) revisited the ED. Children with complex chronic conditions (CCCs) were 2.23 times as likely to revisit the ED as those without a CCC (95% confidence interval: 1.29–3.86). Children admitted and those who received aminopenicillins at the index visit were less likely (63% and 49%, respectively) to revisit the ED (95% confidence interval: 0.24–0.56 and 0.30–0.85, respectively).

CONCLUSIONS:
Although children with CAP have a relatively low revisit rate to the ED, patients who received aminopenicillins at their index visit were statistically less likely to revisit when adjusting for markers of severity (eg, age, CCCs, and disposition at index visit). Clinical factors alone, however, may not be the only indicators of revisits, and additional factors may need to be considered in future studies.
Adherence to AAP Healthy Newborn Discharge Criteria in a Tertiary Care Children’s Hospital
Authors: Arora Nonie S. , Danicek Anne M. , Osborn Rachel R. , Fried Sarah Q. , Negris Olivia R. , Lychuk Karson , Mychaliska Kerry P. , Skoczylas Maria S. , Monroe Kimberly K. 
Published: November 2018

OBJECTIVES:
In 2015, the American Academy of Pediatrics (AAP) published an updated consensus statement containing 17 discharge recommendations for healthy term newborn infants. In this study, we identify whether the AAP criteria were met before discharge at a tertiary care academic children’s hospital.

METHODS:
A stratified random sample of charts from newborns who were discharged between June 1, 2015, and May 31, 2016, was reviewed. Of the 531 charts reviewed, 433 were included in the study. A review of each chart was performed, and data were collected.

RESULTS:
Descriptive statistics for our study population (N = 433) revealed that all 17 criteria were followed &lt;5% of the time. The following criteria were met 100% of the time: clinical course and physical examination, postcircumcision bleeding, availability of family members or health care providers to address follow-up concerns, anticipatory guidance, first appointment with the physician scheduled or parents knowing how to do so, pulse oximetry screening, and hearing screening. These criteria were met at least 95% to 99% of the time: appropriate vital signs, regular void and stool frequency, appropriate jaundice and sepsis management, and metabolic screening. The following criteria were met 50% to 95% of the time: maternal serologies, hepatitis B vaccination, and social risk factor assessment. Four of the criteria were met &lt;50% of the time: feeding assessment, maternal vaccination, follow-up timing for newborns discharged at &lt;48 hours of life, and car safety-seat assessment.

CONCLUSIONS:
Our data reveal that the AAP healthy term newborn discharge recommendations are not consistently followed in our institution.
Editorial
Authors: Leite José Yvan Pereira 
Published: November 2018

A HOLOS publicado o seu quarto número de 2018 com 18 artigos. Os artigos abordam temas das várias áreas do conhecimento, entre elas, bibliometria, educação, engenharias, ensino, gestão e turismo. Estas advém da África do Sul, Brasil, Chile e Portugal.Entre 22 e 28 de outubro realizou-se no mundo a semana internacional do acesso aberto, iniciativa que tem como objetivo disseminar o Acesso Aberto ao conhecimento em escala global. Neste contexto a HOLOS nasce com este objetivo e deseja ampliar seu alcance nos mais diversos quadrantes do globo, bem como faz esforços para a ampliação da cultura Open Acess.Informamos ainda a comunidade acadêmica que outros números da HOLOS estão em fase de diagramação e serão publicados em breve.Por fim, convido-os a acessar os novos artigos publicados! Prof. José Yvan Pereira Leite