bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Log-linear Analysis for Pregnancy Prediction
Authors: Milewska Anna Justyna , Citko Dorota , Jankowska Dorota , Milewski Rafał , Konończuk Katarzyna , Więsak Teresa , Morgan Allen , Milewski Robert 
Published: March 2019

Abstract
Log-linear analysis is a practical tool for examining relationships, successfully applied in many fields of science. This paper discusses the topic of estimation of the chance of getting pregnant in couples that underwent ART insemination. The authors focus on finding significant interactions between variables, on the basis of which statistical models are built. With the use of results of log-linear analysis, a model predicting the chances of achieving a clinical pregnancy that contained interactions was successfully built. Moreover, it was more complete than the model obtained with the use of logistic regression alone.
MRI Texture-Based Recognition of Dystrophy Phase in Golden Retriever Muscular Dystrophy Dogs. Elimination of Features that Evolve along with the Individual’s Growth
Authors: Duda Dorota 
Published: March 2019

Abstract
The study investigates the possibility of applying texture analysis (TA) for testing Duchenne Muscular Dystrophy (DMD) therapies. The work is based on the Golden Retriever Muscular Dystrophy (GRMD) canine model, in which 3 phases of canine growth and/or dystrophy development are identified: the first phase (0–4 months of age), the second phase (from over 4 to 6 months), and the third phase (from over 6 months to death). Two differentiation problems are posed: (i) the first phase vs. the second phase and (ii) the second phase vs. the third phase. Textural features are derived from T2-weighted Magnetic Resonance Imaging (MRI) images. In total, 37 features provided by 8 different TA methods (statistical, filter-based, and model-based) have been tested. The work focuses on finding such textural features that evolve along with the dog’s growth. These features are indicated by means of statistical analyses and eliminated from further investigation, as they may disturb the correct assessment of response to treatment in dystrophy. The relative importance of each remaining feature is then assessed with the use of the Monte Carlo (MC) procedure. Furthermore, feature selection based on the MC procedure is employed to find the optimal subset of age-independent features. Finally, three classifiers are used for evaluating different sets of textural features: Adaptive Boosting (AB), back-propagation Neural Network (NN), and nonlinear Support Vector Machines (SVM). The best subsets of age-independent features ensure 80.0% and 78.5% of correctly identified phases of dystrophy progression, for the first (i) and second (ii) differentiation problem respectively.
Application of Bibliometric Analysis in the Research of Scientific Publications on the Quality Management of Medical Services
Authors: Jończyk Joanna Anna , Olszewska Anna Małgorzata , Jończyk Kamila 
Published: March 2019

Abstract
The aim of the article is to present the results of bibliometric analyzes of scientific papers on the quality management of medical services published in 2001–2017 and indexed in the Scopus database. The analysis uses basic techniques of bibliometric analysis with the technical support of VOSviewer software. The publication proposes an original procedure for analyzing the literature on the subject. The results of the study allowed to determine the trends in the number of publications from 2010 to 2017. At the same time, an analysis of areas of science was presented, in which issues related to the management of the quality of medical services were analyzed, as well as citation of main authors and research centers. The whole analysis concerning the topic of quality management of medical services and bibliometric analysis of scientific works on the concepts and interrelations studied has identified the main six clusters that related to the management of quality of medical services ranging from broadly understood changes in healthcare organizations, internal quality management factors, development issues and education, regulation and standardization of the concept of quality improvement, and technological aspects of quality management in medical services. It seems, therefore, that the conducted studies can be considered as a specific guide for those interested in risk and uncertainty, despite the fact that they are not free of restrictions, for example, due to the narrowing of the time or criteria concerning the types of documents examined. In this context, the analyzes carried out give a wide range of opportunities to propose new research ideas on the above issues in contemporary organizations.
Home Ranges of the Red Fox, Vulpes vulpes (Carnivora, Canidae) and European Badger, Meles meles (Carnivora, Mustelidae), in Oak Forests of Slobozhanshchyna, Ukraine
Authors: Brusentsova N. 
Published: March 2019

Abstract
The research was carried out in 6 territories located in oak forests of Slobozhanshchyna in 2007–2016. Family home ranges were determined using the average nearest neighbour distance between all setts of a sett system for the badgers and between breeding burrows for the foxes. The use of fox and badger family home ranges in different seasons and years was estimated by changes in the use of burrows at the monitoring site of Gomilshanski Lisy National Nature Park. In the oak forests, 173 burrows were studied, among which 75 are used by badgers and 45 by foxes. The area of most of the badger family home ranges in the oak forests is 28–88 hа. The area of the fox family home ranges in the oak forests is 86 to 892 ha. In the oak forests of Slobozhanshchyna, badger and fox family home ranges correspond to the data for similar biotopes in Europe. Seasonal changes of the badger family home range used at the monitoring site in Gomilshanski Lisy NNP in general correspond to literature radio tracking data. Changes in use of the fox family home range de pend on fluctuations of the abundance of rodents.
Implementing inbound open innovation in the CE industry. A case study of Philips-branded Televisions
Authors: Hieltjes Paul , Hieltjes Erwin 
Published: March 2019

Successful innovation requires a company to participate in open innovation and to be connected with the ecosystems around it. For consumer electronics industry, this article distinguishes knowledge, experience and legislation/certification ecosystems. In order to draw the necessary knowledge from ecosystems for inbound open innovation, companies should involve all functional areas in the gathering information and trends from the ecosystems. While most companies involve marketing, development, and production, two key areas for ecosystem knowledge gathering often remain untapped: purchasing and the participation in external standardisation bodies. Successfully using all functional areas to gather ecosystem knowledge will lead to the right innovations at the right time. Regular cross-functional meetings ensure the appropriate translation of collected information and knowledge into portfolio and development choices. The article illustrates this by the example of TP Vision, the makers of Philips-branded televisions, which has successfully applied this innovation process in the consumer electronics (CE) industry.
Using Inside-Out Open Innovation to Recover Abandoned Pharmaceutical Compounds
Authors: Chesbrough Henry , Chen Eric L. 
Published: March 2019

Pharmaceutical drug development costs have risen rapidly over the past twenty years. However, the number of new molecular entities being approved has not increased. As pharmaceutical companies scale back their R&D in light of this deteriorating productivity, significant unmet medical needs remain unaddressed. Much of these rising costs can be traced to work on compounds that are abandoned before getting to market. There is a growing need to recover these abandoned compounds. The inside-out branch of open innovation provides a way to increase the performance of pharmaceutical firms, both in addressing unmet societal needs, and potentially in identifying new revenue sources and business models for a more distributed model of commercializing new drugs. This aspect of open innovation is not much discussed in the literature to date. The medical research community, in conjunction with a number of industry and nonprofit organizations, has started several projects to recover more abandoned compounds. These new initiatives are still at an early stage, and have not received much critical evaluation to date. Examining four of these initiatives, we find that they do extend the cognitive frames in the research phase, while doing less to extend those frames in the commercialization phase.
Coping with big: Does big data lead to ‘bigger’ innovation?
Authors: Torkkeli Marko , Mention Anne-Laure , Pinto Ferreira João José 
Published: March 2019

This Spring Issue will discuss about big data and multiple aspects of its usability and applicability. Many of us have seen blockbuster movies Back to the future (premiere in 1985), The Terminator (1984) or Minority report (2002). The unifying element of the above mentioned movies is that manuscripts are introducing a superior competitive advantage factor. The protagonists create an advantage by having either real-time data (sometimes from the future) or all relevant (big and historical) data with enormous computing capacity over competitors. A bit after first two of those movies premiered, NASA scientists Cox and Ellsworth (1997) published an article where term ‘big data’ appeared first time (Press, 2014). Intelligence needs to be topped up in a way to create advantage. Data has been there for a long time, in all forms and sizes. It is applied in almost single every business sector and it is getting faster in sense of usability. The data storage capacity has been exponentially increasing over time, but the usability of this wealth of data remains a critical issue.(...)
Motivation for increasing creativity, innovation and entrepreneurship. An experience from the classroom to business firms
Authors: Gerardo Barroso-Tanoira Francisco 
Published: March 2019

This study presents a program for increasing students´ motivation to be creative, innovative and entrepreneurs, based on interventions in business firms for improving employee performance through the use of critical and creative thinking. Results showed that the program was effective both for workers and students, and that the most important factor to be considered for enhancing creativity, innovation and entrepreneurship is intrinsic motivation. People are more creative when they do what they like, instead of just doing what they know or what they are told to. The more creative people are, the better performance and higher productivity could be expected. This is an opportunity for educational institutions to set links with business firms and take a more active role in human and business development.
Emotional and Social Intelligence as ‘Magic Key’ in Innovation: A Designer’s call toward inclusivity for all
Authors: Henning Buehring Joern , Moore Patricia 
Published: March 2019

This paper draws attention to the emotional and social intelligence of individuals - encompassing self- and social awareness, empathy and social skills; when applied to innovation, it can boost employee creativity, diversity, risk taking, learning, adapting, and strategic decision making which is deemed as critical in meeting the challenges of the 21stCentury. Meanwhile, Design in business and innovation have become increasingly synonymous in both meaning (e.g. design and futures thinking) and reach (e.g. products, services, business models, and systems), placing renewed focus on creative human capital as the organizations’ greatest asset. Expanding the conversation of Design in business as a strategic role to develop user-centered innovations through ‘inclusivity for all’, it is proposed that an organization’s emotional and social intelligence may well bear the 'magic key' toward competitive resilience and long-term survival.
Updating the Model: The Case for Independent Pharmacy to Embrace Digital Health
Authors: Cornell W Kyle , Clauson Kevin A , Cain Jeff 
Published: March 2019

Objectives: To advocate for independent pharmacy to embrace digital health as a means to improve patient outcomes and compete more strongly in an increasingly competitive business environment.
Summary: Independent pharmacies are positioned to be at the forefront of adopting digital health tools for a variety of reasons. They often can make changes to their business model faster than a major retail chain, are often in rural locations where few other providers are located, and are already starting to offer the types of clinical services that can be greatly aided by digital health. This commentary presents the case for a change in the current model of pharmacy practice to one which embraces digital health. The role of the pharmacist would grow beyond exclusively medication management to incorporate tools such as wearable health trackers and mobile phone applications. By utilizing digital health, the pharmacist can obtain a greater amount of patient health data via an asynchronous electronic uploading process, and then use that data to further improve their ability to offer clinical services.
Conclusion: Digital health is a powerful tool that should be embraced by independent pharmacy. By leveraging digital health, pharmacies can improve both accessibility and quality of care, thus providing a competitive advantage in the retail marketplace.

Article Type: Commentary
Межэтническое взаимодействие русских и тувинцев в советской и постсоветской Туве (на примере национально-смешанных семей)
Authors: Dorzhu Zoya Yu. 
Published: March 2019

В статье анализируются проблемы межэтнических браков между тувинцами и русскими в Республике Тыва, которые рассматриваются как один из аспектов межэтнического взаимодействия двух самых многочисленных этнических групп населения. Хронологический период: советское время (1944–1991 гг.) и постсоветское (с 1991 г. по настоящее время. Источниковая база работы: статистические данные за 1979, 1989, 2002, 2007, 2010 гг.; данные опроса жителей Кызыла разных национальностей, проведенный автором в марте-апреле 2017 г.; личные наблюдения и материалы интервью 2015–2018 гг. с 20 респондентами старше 65 лет, находящимися в межнациональном браке. Взаимодействие тувинцев и русских имеет двухвековую историю. Оно отразилось и на демографических процессах. Если раньше тувинцы предпочитали внутриэтнические брачные связи, то изменение демографической ситуации, межнациональная интеграция обусловили и появление межнациональных браков. Анализируются динамика числа браков, мотивы и факторы выбора партнера для смешанного брака, реакция окружающих, проблема детей в смешанных семьях.Образование смешанных семей влекло за собой качественно новые черты культуры, домашнего быта, традиций, отличающих их семейный уклад от семейного быта однонациональных семей, к которым ранее принадлежали супруги. Параллельно с этим в смешанных семьях происходили языковые процессы, межэтническое общение способствовало распространению двуязычия, а также широкому распространению родственных связей, которые обеспечивали этнополитическую устойчивость многонационального региона.В современной Туве также часто встречаются национально-смешанные семьи, однако общественное отношение к таким бракам резко изменилось. Отрицательное отношение к межнациональным бракам связано с религиозными различиями, разными традициями и обычаями. Из-за этого возникают между супругами разногласия, такие браки люди начинают расценивать как неустойчивые. Свою роль сыграло и усиление националистических тенденций в постсоветском обществе.
HUBUNGAN KONDISI LINGKUNGAN FISIK TERHADAP TINGKAT KEPADATAN LARVA Aedes sp DI SEKOLAH DASAR WILAYAH KECAMATAN KASIHAN, BANTUL, DI YOGYAKARTA
Authors: Astuti Puji , Lustiyati Elisabeth Deta 
Published: March 2019

Latar belakang: Data Dinas Kesehatan DIY 2016 menunjukan bahwa kasus DBD tertinggi berada di Kecamatan Kasihan, Kabupaten Bantul. Salah satu faktor yang mempengaruhi kepadatan larva Aedes sp adalah lingkungan fisik meliputi intensitas cahaya, ventilasi, drainage, dan jarak antar bangunan. Hasil survey larva diperoleh hasil dari 11 kontainer, empat positif larva Aedes sp sehingga diperoleh Container Index (CI) 36% tergolong kepadatan tinggi. Penelitian ini bertujuan untuk mengetahui hubungan antara kondisi lingkungan fisik dengan tingkat kepadatan larva Aedes sp.Metode: Jenis penelitian ini merupakan observasional analitik dengan rancangan cross sectional. Jumlah sampel dalam penelitian ini sebanyak 30 sekolah dasar. Teknik sampling menggunakan total sampling dengan analisis data menggunakan uji korelatif Spearman (α= 0,05).Hasil: Kondisi lingkungan fisik sekolah yang telah memenuhi persyaran pada variabel intensitas cahaya (13,3%), ventilasi (16.7%), drainage (56,7%), jarak antar bangunan memenuhi syarat (60,0%). Hasil perhitungan kepadatan larva Aedes sp di sekolah dasar wilayah Kecamatan Kasihan diperoleh hasil House Index (HI)=90%, Container Index (CI) rata-rata 25,23%, dan Breteau Index (BI) = 333 dengan DF = 9 tergolong kategori kepadatan tinggi.Hasil penelitian menunjukkan terdapat tiga variabel yang berhubungan dengan kepadatan larva Aedes sp yaitu intensitas cahaya (p=0,029), ventilasi (p=0,004), dan drainase (p=0,011).Kesimpulan: Ada hubungan antara intensitas cahaya, ventilasi dan drainase dengan kepadatan larva Aedes sp.
99mTc radiolabeled archaeosomes as a potential melanoma imaging agent
Authors: Cabral Pablo , Cabrera Mirel , Tassano Marcos , Fernadez Marcelo , Gambini Juan Pablo 
Published: March 2019

Background: Melanoma incidence is growing worldwide. Although recent advances in imaging, there isn`t still available a specific melanoma agent that can be used for melanoma staging. Archaeosomes may be defined as liposomes composed of one or more polar lipids extracted from the Archaea domain (Archaebacterium). Objective: Â As liposomes have been used as vehicles for drugs and isotopes, the aim of this work was to 99mTc radiolabel archaeosomes and evaluates its potential role as a melanoma imaging agent.Methods: Archaeosomes were prepared by hand shaken method and were radiolabeled with 99mTc; Radiolabelling efficiency and purity was evaluated through different chromatographic systems. In vitro stability of 99mTc-DTPA-archaeosomes was performed through L-cysteine challenge.Results: Archaeosomes size distribution was determined by laser light scattering, having nanometer size between 90 and 120 nm. Radiolabelling efficiency was greater than 90%; 99mTc-DTPA-Archaeosomes presented a radiochemical purity superior to 80% evaluated 24 hours post radiolabelling. For the highest concentration of L-cysteine (30mM) and 1h incubation,Â radiochemical purity was 92.90 %, 6.41 % was bound to cysteine and 0.69 % remained as 99mTcO4- . Biodistribution and scintigraphic imaging studies in healthy C57 black mice showed high liver, spleen uptake and renal elimination. Melanoma bearing mice, had similar biodistribution as healthy mice but increased melanoma uptake, with T/M ratio of 46 Â±3.7.Conclusions: Â Our results show the feasibility of 99mTc radiolabelling archaeosomes and their potential role as a melanoma imaging agent.
SÍNDROME DE DEISCÊNCIA DO CANAL SEMICIRCULAR SUPERIOR
Authors: Vianas Gomes Weidmmer Rogério , Camillo Felipe Feldman De Mendonça , Lima Caio Gomes de , Villela Maria Ururahy Póvoa Duarte , Siqueira Luiza Barroso 
Published: March 2019

A SDCSS é uma doença rara (pouco estudo no Brasil) e que em primeiro aspecto, em 1998 por Minor et al.foi descrita como uma degradação da camada óssea responsável por revestir o canal semicircular superior. Está diretamente correlacionada a sintomas vestibulares e alguns pacientes podem apresentar quadros de eufonia e perda auditiva. É válido ressaltar que ainda não se conhece a etiopatologia da doença peculiaridade da síndrome em questão. Em contrapartida, há hipóteses que acreditam que o erro ocorreria durante o desenvolvimento da camada óssea que recobre o canal semicircular. Como diagnóstico, entende-se que o exame clínico é de suma importância, pelo fato dos exames estipulados como padrão ouro não serem capazes de expor alterações significativas. Quando ocorre uma suspeita, os indivíduos devem ser submetidos ao protocolo da avaliação com os testes estudados, para ser feita a confirmação da HD (hipótese diagnóstica). Por fim, entende-se que SDCSS dever ser incluída entre as causas de vertigem como de hipoacusia de transmissão e embora seja uma alteração incomum, há diversos aspectos fisiopatológicos ainda não escritos. Possui a vantagem de serem evitadas abordagens terapêuticas inapropriadas. (Minor et al, 2001)
Palavras-chaves: Síndrome de Deiscência do Canal Semicircular Superior, canal semicircular superior, degradação da camada óssea, sintomas vestibulares, protocolo da avaliação, causas de vertigem, abordagens terapêuticas inapropriadas.
ESCLEROSE LATERAL PRIMÁRIA
Authors: Lopes Thaina Pereira , De Freitas Pedro Henriques Portes Ferreira , Melo Thais Ribeiro , De Sales Luiza Reis , Neri Vanderson Carvalho 
Published: March 2019

Introdução: Esclerose Lateral Prima?ria (ELP) é uma doenc?a neurodegenerativa rara de origem desconhecida caracterizada por envolvimento do trato corticoespinhal, que comumente se manifesta por espasticidade progressiva, porém sem lesão do segundo neurônio motor.
Objetivos: Relatar um caso de ELP, realizar revisão da literatura e dos critérios diagnósticos.
Metodologia: relato de caso e revisão da literatura.
Relato do Caso: Mulher, branca, hígida, apresentou aos 35 anos quadro progressivo de alteração da marcha, do equilíbrio e perda na orientação dos movimentos. Redução progressiva da força em membros superiores, posterior ao quadro de paraparesia instalado. Inicia-se também nesse período importante perda ponderal em razão de disfagia associada. Progrediu para tetraparesia, e disfonia severas sem qualquer verbalização aos 37 anos. Na evolução observou-se comprometimento de vários domínios da cognição, além de grande labilidade emocional. Ao exame observa-se tetraparesia espástica, hiperreflexia nos quatro membros, clonus simétrico, sinais de Babinski e Hoffman bilaterais, e afasia motora. Exames laboratoriais, TC de tórax e abdômen, EEG sem alterações. RM de crânio demonstrando atrofia cortical difusa, dilatação ventricular compensatória; RM de coluna sem alterações. ENMG sem sinais de acometimento do segundo neurônio motor.
Conclusões: Trata-se de um caso de doença neurodegenerativa do neurônio motor superior, com acometimento de funções cognitivas. A paciente preenche critérios clínicos propostos por Pringle et al., 1992 para o diagnóstico da ELP. Outras causas de lesão do neurônio motor foram excluídas para a confirmação diagnóstica.
Turist Akışı, Konaklama Fiyatları ve Döviz Kurları: Türkiye İçin Bir Nedensellik Analizi
Authors: HOPOĞLU Sertaç , ERYÜZLÜ Hakan 
Published: March 2019

Çalışmada konaklama fiyatları ve döviz kurlarının Türkiye’yi
ziyaret eden turist sayılarına etkisi 2005:1-2018:6 dönemi için
araştırılmıştır. Bağımsız değişkenler olarak aylık konaklama fiyat endeksi ve
Türk Lirası’nın Türkiye’nin önemli kaynak pazarlarının paralarına karşı aylık
ortalama nominal kurları kullanılmıştır. Çalışmada yöntem olarak Hacker &amp;
Hatemi-J (2006) bootstrap nedensellik testi ve seriler arasında asimetrik nedensellik analizleri için Hatemi-J(2012) bootstrap asimetrik nedensellik testi
uygulanmıştır. Elde edilen bulgulara göre
konaklama fiyatları ve Türkiye’ye olan turist akışı arasında %10 anlamlılık
düzeyinde simetrik bir nedensellik ilişkisi vardır. Ziyaretçi sayılarından Euro
ve Pound kurlarına doğru simetrik nedensellik bulunmuştur. Çalışmada sadece
ziyaretçi sayısındaki negatif şoklar ve Pound kurundaki pozitif şoklar arasında
asimetrik nedensellik ilişkisi elde edilmiştir. Bu bulgulara göre Türkiye’ye
olan turist akışının sürdürülebilir olması için konaklama fiyatlarına dikkat
edilmesi ve özellikle Birleşik Krallık’tan gelecek potansiyel turistler için
pazarlama stratejileri üretirken Pound/TL kurunun dikkate alınması
gerekmektedir.