bluuebunny/crossref_metadata_2025_split huggingface dataset:
Workplace sexual harassment, workplace deviance, and family undermining
Authors: Zhu Hong , Lyu Yijing , Ye Yijiao 
Published: February 2019

PurposeThis study aims to examine the effect of workplace sexual harassment (WSH) on hospitality employees’ workplace deviance and family undermining behaviors by focusing on the mediating effect of depression.Design/methodology/approachThis research uses a three-phase field survey to collect data from hotels in China with a final sample of 266 hospitality employees. Data analysis techniques include descriptive statistics, confirmative factor analysis and hierarchical multiple regression.FindingsThis research finds that WSH is positively related to workplace deviance; WSH positively affects family undermining; depression is a mediator in the relationship between WSH and workplace deviance; and depression mediates the relationship between WSH and family undermining.Originality/valueFirst, this research goes beyond the existing WSH literature by extending outcome variables to workplace deviance. Second, it is among the first to investigate the relationship between WSH and hospitality employees’ family life. Third, the examination of depression as a mediator advances the literature by unraveling the mediating mechanism underlying the effects of WSH on hospitality employees.
China goes global: provenance, projection, performance and policy
Authors: Buckley Peter 
Published: February 2019

Purpose
The purpose of this paper is to examine the provenance, projection, performance and policy concerning Chinese outward foreign direct investment (COFDI) and speculate on the existence of “China’s international strategy”.

Design/methodology/approach
This study includes a comprehensive review of COFDI.

Findings
There is evidence of not only the successful coordination of COFDI, but also context, conflict and independent decision making (in Chinese firms) playing an essential role in the determination of the direction, control and outcomes of the outward FDI, respectively.

Research limitations/implications
There is a great scope for further research on COFDI, as the lack of data prevents definitive conclusions, particularly on the outcomes and performance of the investments.

Originality/value
The paper presents an original synoptic view of key elements in the globalisation of the world economy and in the projection of Chinese economic power.
Financial sustainability of statewaqfinstitutions (SWIs) in Malaysia
Authors: Sulaiman Maliah , Alhaji Zakari Muntaka 
Published: February 2019

PurposeThis paper aims to measure the financial sustainability and vulnerability of state-managedwaqfinstitutions in Malaysia.Design/methodology/approachThe study mainly applied the commonly used Tuckman and Chang’s (1991) model to measure the financial health of non-profits. Content and ratio analysis of the 2014 audited reports of seven institutions were used to determine their equity balance, revenue concentration, administrative costs and operating margin ratios.FindingsThe results indicate that only onewaqfinstitution was financially sustainable in all the four components.Research limitations/implicationsBecause the data used are not the latest and focussed only on a single year, the findings may not be necessarily true, currently. Second, the study focussed only on Malaysia. Thus, the results may not be generalisable to otherwaqfsin other countries or to privately managedwaqfinstitutions. Accordingly, future research should address these limitations.Practical implicationsThe findings provide useful insights into the financial sustainability ofwaqfinstitutions and highlight the need for policymakers in Malaysia and other Muslim countries to give due attention to the holistic accountability ofwaqfinstitutions to ensurewaqf’ssystematic revival.Originality/valueThe paper, being the first to investigate the financial sustainability and vulnerability of statewaqfinstitutions in Malaysia, serves as a reference for future researchers.
Building committedWaqif: the role of information disclosure
Authors: Abd Jalil Mohamad Isa , Yahya Sofri , Allah Pitchay Anwar 
Published: February 2019

PurposeThe purpose of this study is to conceptualise the relationship between information disclosure andWaqifcommitment, taking into consideration the role of level of trust (mediator variable) and communication and type of payment (moderator variables).Design/methodology/approachThe conceptual framework is developed from the theory of social exchange (mediated philanthropy model) and selected previous literature concerning commitment.FindingsAccording to previous empirical research, a conceptual framework was developed to facilitate further analysis in the study. Nine propositions were raised in this paper where the factor of communication and payment method is proposed to no longer the factor that determined commitment but as moderator. There is five antecedent of information disclosure proposed, which is basic information, financial information, non-financial information, future information and governance information. Also, trust is offered to be the mediator variable between information disclosure andWaqfcommitment.Research limitations/implicationsBy realising many factors that may influence the commitment ofwaqfsuch as demonstrable utility, emotional utility and familial utility, this study only focusses on the effect of information disclosure.Practical implicationsThis paper provides an opportunity for further empirical studies to prove the relationship between information disclosure andWaqfcommitment. This paper also brought opportunities to investigate both conceptually and empirically, other factors that could affectWaqfcommitment.Originality/valueTo the best of the author’s knowledge, few studies have been done concerning donors commitment. While there are none yet, the research examinedWaqfcommitment. The originality value of this study is that there is a gap in knowledge regarding the analysis ofWaqfcommitment, the level of trust amongwaqifis the information thatWaqfexpected, the preferred communication between Mutawalli andWaqfand type of payment thatWaqffavoured. This study is believed to be a novel based on the framework developed.
Revival of favus in Japan caused by Trichophyton schoenleinii
Authors: Iwasa Kentaro , Ogawa Kohei , Azukizawa Hiroaki , Tanabe Hiroshi , Iwanaga Tomoyuki , Anzawa Kazushi , Mochizuki Takashi , Asada Hideo 
Published: February 2019

AbstractFavus is a type of dermatophytosis known to produce yellow scutula around hair follicles. Most cases of this disease worldwide are infections of Trichophyton schoenleinii. Favus has rarely been reported in Japan throughout the last four decades, and T. schoenleinii has not been clinically isolated in any case during the period. Here, we report a case of favus of vellus hair observed in a 63‐year‐old Japanese woman. Fungal culture showed negative; however, we detected fungal elements in the crust and hair bulbs by Grocott staining. Pathogenic fungi were identified as T. schoenleinii by polymerase chain reaction‐based DNA sequencing, targeting the internal transcribed spacer regions of the rRNA gene using the formalin‐fixed, paraffin‐embedded tissue sample. She was successfully treated with p.o. administration of terbinafine and topical application of luliconazole cream.
The impact of uncertainty on cooperation intent in a conservation conflict
Authors: Pollard Chris R. J. , Redpath Steve , Bussière Luc F. , Keane Aidan , Thompson Des B. A. , Young Juliette C. , Bunnefeld Nils 
Published: February 2019

Abstract

Stakeholder cooperation can be vital in managing conservation conflicts. Laboratory experiments show cooperation is less likely in the presence of uncertainty. Much less is known about how stakeholders in real‐life conservation conflicts respond to different types of uncertainty.

We tested the effects of different sources of uncertainty on cooperative behaviour using a framed field experiment and interviews. The experiment compared a baseline scenario of perfect certainty with scenarios including either: (a) scientific uncertainty about the effectiveness of a conflict‐reduction intervention; (b) administrative uncertainty about intervention funding; or (c) political uncertainty about the extent of community support. We applied these scenarios to a conservation conflict in the Outer Hebrides, Scotland, involving the management of geese to simultaneously meet both conservation and farming objectives. We asked 149 crofters (small‐scale farmers) if they would commit to cooperate with others by helping fund a goose management plan given the three sources of uncertainty.

On average, intention to cooperate was highest (99%) in scenarios without uncertainty, and lowest under administrative uncertainty (77%). Scientific uncertainty and political uncertainty both had less of an effect, with over 95% of crofters predicted to be willing to cooperate in these scenarios. Crofters who indicated concern for other crofters suffering the impact of geese were more likely to cooperate. The longer an individual had been a crofter, the less likely they were to cooperate.

Synthesis and applications. Crofters’ intention to cooperate is high but lessened by uncertainty, especially over the commitment from other stakeholders such as government, to cooperate on goose management. Existing cooperation on goose management may be at risk if uncertainty is not reduced outright or commitments between parties are not strengthened. This has wide applicability, supporting the need for researchers and government advisers to: (a) determine how uncertainty will impact intention of stakeholders to cooperate; and (b) take steps (such as uncertainty reduction, communication or acceptance) to reduce the negative impact of uncertainty on cooperation.
The significance of retention trees for survival of ectomycorrhizal fungi in clear‐cut Scots pine forests
Authors: Sterkenburg Erica , Clemmensen Karina E. , Lindahl Björn D. , Dahlberg Anders 
Published: February 2019

Abstract

Forestry with short stand generations and simplified forest structures has markedly affected forest biodiversity. One group of organisms adversely affected by clear‐cutting is ectomycorrhizal (ECM) fungi, as they are associated with the roots of living trees. Retention forestry is a way of reducing logging impacts and enhancing biodiversity conservation. Increasing the proportion of trees retained at harvest may improve ECM fungal diversity.

We investigated the potential for lifeboating of ECM fungi through the harvesting phase in an experimental field study in a 190‐year‐old Scots pine forest in northern Sweden. The experiment comprised four levels of tree retention—unlogged forest, plots with 60% or 30% of evenly distributed trees retained and clear‐cuts without retained trees. We sampled soils and determined identities, frequencies and relative abundances of ECM fungal species during 3 years following logging through the use of high‐throughput sequencing of amplified ITS2 markers.

We identified 149 ECM fungal species, with the five most abundant species accounting for 50% of the total ECM fungal amplicons. Three years after harvesting, the proportion of ECM sequences in the total amplicon pool had decreased proportionally to the extent of tree removal. In clear‐cuts, ECM fungal relative abundance had decreased by 95%, while ECM fungal species richness had declined by 75%, compared to unlogged plots.

Tree retention enabled the maintenance of the most frequent ECM species, while more lowly abundant species were progressively lost at random with increasing level of tree removal. Five of the most frequent ECM fungal species remained present after clear‐cutting, probably associated with pine seedlings.

Synthesis and applications. Tree retention can moderate short‐term and potentially also long‐term logging impacts on ECM fungi. Local ECM fungal diversity is preserved in proportion to the amount of retained trees. Abundant species may be largely maintained, even by low levels of tree retention and on naturally established seedlings. However, conservation of more infrequent species requires higher levels of tree retention, and our results suggest that around 75% of the ECM species are lost with the forest certification standard of 5% retention trees left at logging.
Dynamin‐like protein 1 cleavage by calpain in Alzheimer’s disease
Authors: Jiang Sirui , Shao Changjuan , Tang Fangqiang , Wang Wenzhang , Zhu Xiongwei 
Published: February 2019

AbstractAbnormal mitochondrial dynamics contributes to mitochondrial dysfunction in Alzheimer's disease (AD), yet the underlying mechanism remains elusive. In the current study, we reported that DLP1, the key mitochondrial fission GTPase, is a substrate of calpain which produced specific N‐terminal DLP1 cleavage fragments. In addition, various AD‐related insults such as exposure to glutamate, soluble amyloid‐β oligomers, or reagents inducing tau hyperphosphorylation (i.e., okadaic acid) led to calpain‐dependent cleavage of DLP1 in primary cortical neurons. DLP1 cleavage fragments were found in cortical neurons of CRND8 APP transgenic mice which can be inhibited by calpeptin, a potent small molecule inhibitor of calpain. Importantly, these N‐terminal DLP1 fragments were also present in the human brains, and the levels of both full‐length and N‐terminal fragments of DLP1 and the full‐length and calpain‐specific cleavage product of spectrin were significantly reduced in AD brains along with significantly increased calpain. These results suggest that calpain‐dependent cleavage is at least one of the posttranscriptional mechanisms that contribute to the dysregulation of mitochondrial dynamics in AD.
The crowding out effect of booming real estate markets on corporate TFP: evidence from China
Authors: Lu Bing , Tan Xiaofen , Zhang Jinhui 
Published: February 2019

AbstractThis paper explores the impact of housing price appreciation on corporate total factor productivity (TFP) in Chinese A‐share listed corporations. Results show that increasing real estate prices negatively affect corporate TFP. Meanwhile, we find that the deterring effect is especially significant for state‐owned enterprises (SOEs), large corporations and manufacturing corporations. This research further provides suggestive evidence that managerial myopia may be one potential explanation for the crowding out effect of increasing housing prices. When home purchase is under restriction, however, the negative impact of rising housing prices on corporate TFP declines sharply. This study illustrates the efficiency cost of China's booming real estate market.
Combination lenalidomide‐rituximab immunotherapy activates anti‐tumour immunity and induces tumour cell death by complementary mechanisms of action in follicular lymphoma
Authors: Chiu Hsiling , Trisal Preeti , Bjorklund Chad , Carrancio Soraya , Toraño Estela G. , Guarinos Carla , Papazoglou Despoina , Hagner Patrick R. , Beldi‐Ferchiou Asma , Tarte Karin , Delfau‐Larue Marie‐Hélène , Morschhauser Franck , Ramsay Alan G. , Gandhi Anita K. 
Published: February 2019

SummaryChemotherapy plus rituximab has been the mainstay of treatment for follicular lymphoma (FL) for two decades but is associated with immunosuppression and relapse. In phase 2 studies, lenalidomide combined with rituximab (R2) has shown clinical synergy in front‐line and relapsed/refractory FL. Here, we show that lenalidomide reactivated dysfunctional T and Natural Killer (NK) cells ex vivo from FL patients by enhancing proliferative capacity and T‐helper cell type 1 (Th1) cytokine release. In combination with rituximab, lenalidomide improved antibody‐dependent cellular cytotoxicity in sensitive and chemo‐resistant FL cells, via a cereblon‐dependent mechanism. While single‐agent lenalidomide and rituximab increased formation of lytic NK cell immunological synapses with primary FL tumour cells, the combination was superior and correlated with enhanced cytotoxicity. Immunophenotyping of FL patient samples from a phase 3 trial revealed that R2 treatment increased circulating T‐ and NK‐cell counts, while R‐chemotherapy was associated with reduced cell numbers. Finally, using an in vitro model of myeloid differentiation, we demonstrated that lenalidomide caused a reversible arrest in neutrophil maturation that was distinct from a cytotoxic chemotherapeutic agent, which may help explain the lower rates of neutropenia observed with R2 versus R‐chemotherapy. Taken together, we believe these data support a paradigm shift in the treatment of FL – moving from combination immunochemotherapy to chemotherapy‐free immunotherapy.
Immune off‐target effects of Brentuximab Vedotin in relapsed/refractory Hodgkin Lymphoma
Authors: Romano Alessandra , Parrinello Nunziatina L. , Chiarenza Annalisa , Motta Giovanna , Tibullo Daniele , Giallongo Cesarina , La Cava Piera , Camiolo Giuseppina , Puglisi Fabrizio , Palumbo Giuseppe A. , Di Raimondo Francesco 
Published: February 2019

SummaryHodgkin Lymphoma (HL) is associated with deep microenvironment re‐shaping and myeloid dysfunction. Given that only limited data are available regarding the role of Brentuximab Vedotin (BV) as single agent in transplant‐naive relapsed/refractory (R/R) patients and its off‐target effects on immune system, we evaluated the amount of regulatory T‐cells (T‐regs), myeloid‐derived suppressor cells (MDSC) subpopulations, and their functional marker, serum arginase‐1 (s‐Arg‐1), in peripheral blood of 15 consecutive R/R HL patients. After a median of four BV cycles, the overall response rate (complete response + partial response) was 47%, with 4 (27%) complete metabolic remissions. BV reduced the absolute number of three MDSC subtypes and s‐Arg‐1 levels. Patients with baseline s‐Arg‐1 ≥200 ng/ml had inferior progression‐free survival at 36 months compared to those with low s‐Arg‐1. T‐regs dysfunction was recovered by BV: absolute T‐regs count was increased after treatment with BV, independently of metabolic response achieved, with a significant reduction of CD30+T‐regs. Our data disclose off‐target effects of BV in the microenvironment that could explain its deep and durable clinical efficacy.
Efficacy of venetoclax monotherapy in patients with relapsed chronic lymphocytic leukaemia in the post‐BCRinhibitor setting: aUKwide analysis
Authors: Eyre Toby A. , Kirkwood Amy A. , Gohill Sat , Follows George , Walewska Renata , Walter Harriet , Cross Matthew , Forconi Francesco , Shah Nimish , Chasty Richard , Hart Alistair , Broom Angus , Marr Helen , Patten Piers E. M. , Dann Andy , Arumainathan Arvind , Munir Tal , Shankara Paneesha , Bloor Adrian , Johnston Rosalynd , Orchard Kim , Schuh Anna H. , Fox Christopher P. ,   the UK CLL Forum
Published: February 2019

SummaryVenetoclax is aBCL2 inhibitor with activity in relapsed/refractory (R/R) chronic lymphocytic leukaemia (CLL). We conducted a multi‐centre retrospective analysis of 105 R/RCLLpatients who received venetoclax pre‐National Health Service commissioning. The median age was 67 years and median prior lines was 3 (range: 1–15). 48% hadTP53disruption. At ≥2 lines, 60% received a Bruton Tyrosine Kinase inhibitor (BTKi) and no prior phosphoinositide 3‐kinase inhibitor (Pi3Ki), 25% received a Pi3Ki and no priorBTKi, and 10% received both. Patients discontinued B cell receptor inhibitor (BCRi) because of toxicity in 44% and progression in 54%. Tumour lysis syndrome risk was low, intermediate or high in 27%, 25%, and 48% respectively. Overall response was 88% (30% complete response [CR]). The overall response rate was 85% (CR23%) inBTKi‐exposed patients, 92% (CR38%) in Pi3Ki‐exposed patients and 80% (CR20%) in both (P = 0·59). With a median follow‐up of 15·6 months, 1‐year progression‐free survival was 65·0% and 1‐year overall survival was 75·1%. Dose reduction or temporary interruption did not result in an inferior progression‐free or discontinuation‐free survival. Risk of progression or death after stopping a priorBCRi for progression was double compared to those stopping for other reasons (predominantly toxicity) (Hazard Ratio 2·01P = 0·05). Venetoclax is active and well tolerated in R/RCLLpost ≥1BCRi. Reason(s) for stoppingBCRi influences venetoclax outcomes.
Induction of C‐C motif chemokine ligand 2 through Toll‐like receptor 3 signaling in human cerebral microvascular endothelial cell/D3 cells: possible regulation by nuclear factor‐κB
Authors: Sassa Naoko , Hirono Koji , Shiratori Toshihiro , Kawaguchi Shogo , Matsumiya Tomoh , Yoshida Hidemi , Seya Kazuhiko , Tanaka Hiroshi , Imaizumi Tadaatsu 
Published: February 2019

AbstractObjectiveC‐C motif chemokine ligand 2 (CCL2) is a potent chemokine that plays an important role in host defense and inflammatory diseases in the central nervous system. Toll‐like receptor 3 (TLR3) is a pattern recognition receptor that recognizes viral double‐stranded RNAs. In the present study, we examined whether a TLR3 agonist induces CCL2 expression in brain microvascular endothelial cells, and investigated the mechanism underlying upregulation of CCL2 expression through TLR3 signaling.MethodsA human brain microvascular endothelial cell line, human cerebral microvascular endothelial cell (hCMEC)/D3 was treated with a TLR3 agonist, polyinosinic‐polycytidylic acid (poly IC). The mRNA and protein expression of CCL2 were evaluated using real‐time reverse transcription polymerase chain reaction and enzyme‐linked immunosorbent assay, respectively. The role of TLR3 and nuclear factor‐κB (NF‐κB) were examined with RNA interference. We also examined the effect of pretreatment with an NF‐κB inhibitor, SN50, an interferon regulatory factor 3 inhibitor MR67307 and human type I interferon neutralizing antibody mixture on poly IC‐induced CCL2 expression.ResultsExpression of CCL2 was induced by poly IC. Poly IC‐induced CCL2 expression was decreased by knockdown of TLR3 or NF‐κB p65 and by pretreatment with SN50. Neither MR67307 nor human type I interferon neutralizing antibody mixture affected the CCL2 expression induced by poly IC.ConclusionsCCL2 expression was induced by poly IC through TLR3 signaling, and NF‐κB is involved in this reaction. CCL2 produced by human brain endothelial cells might induce the infiltration of monocytes followed by immune and inflammatory reactions in the brain, and could be involved in the pathogenesis of viral encephalitis.