bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penile calciphylaxis in a patient with end-stage renal disease: a case report and review of the literature
Authors: Yang Ti-Yuan , Wang Tao-Yeuan , Chen Marcelo , Sun Fang-Ju , Chiu Allen W. , Chen Yu-Hsin 
Published: May 2018

Abstract
Penile calciphylaxis is a rare cause of penile gangrene that presents in patients with end-stage renal disease. The rates of comorbidity and mortality of penile calciphylaxis are extremely high. Unlike other penile gangrene, such as Fournier’s gangrene, the benefit of aggressive surgical therapy is controversial. Here we present a case of penile calciphylaxis in a 43-year-old man with end-stage renal disease on hemodialysis. He received total penectomy but died due to multisystem complications 2 weeks after surgery. We review the literature on the management options and outcomes in patients with penile calciphylaxis.
Crystal structure of (E)-2-(1-((2-aminophenyl)imino)ethyl)-4-bromophenol, C14H13BrN2O
Authors: Hong Yong , Liu Wei 
Published: May 2018

Abstract
C14H13BrN2O, monoclinic, P21 (no. 4), a = 6.8679(5) Å, b = 7.7096(5) Å, c = 12.4043(7) Å, β = 101.332(2)°, V = 643.99(7) Å3, Z = 2, R
gt(F) = 0.0294, wR
ref(F
2) = 0.0691, T = 293(2) K.
Effect of High-Dose, Short-Duration β-Alanine Supplementation on Circulating IL-10 Concentrations During Intense Military Training
Authors: Hoffman Jay R. , Gepner Yftach , Hoffman Mattan W. , Zelicha Hila , Shapira Shachar , Ostfeld Ishay 
Published: May 2018

Abstract
Hoffman, JR, Gepner, Y, Hoffman, M, Zelicha, H, Shapira, S, and Ostfeld, I. Effect of high dose, short-duration β-alanine supplementation on circulating IL-10 concentrations during intense military training. J Strength Cond Res 32(10): 2978–2981, 2018—This study examined the effect of β-alanine as a potential anti-inflammatory agent during intense military training. Twenty soldiers (20.1 ± 0.6 years) from an elite combat unit were randomly assigned to either a β-Alanine (BA) or placebo (PL) group. Soldiers were provided with 12 g·d−1 of either BA or PL for 7 days between 2 intensive periods of navigational training and restricted sleep. During the initial training period, soldiers navigated on average 27.8 km·d−1 with ∼50% of their body mass in their packs for 5 days. Soldiers returned to base and began a 7-day supplementation program before departing for an additional period of intense field training. During the second period of field training, soldiers navigated 10 km·d−1 for an additional 5 days, carrying similar loading as the initial week, performed tactical missions, and slept approximately 5 hours per day. Blood samples were obtained after the initial training period and after the second training period and analyzed for IL-10. Magnitude-based inferences that were used to provide inferences on the true effect BA may have had on IL-10 concentrations compared with PL, calculated from 90% confidence intervals. Data analysis indicated that changes in circulating IL-10 concentrations (mean difference 0.86 pg·ml−1) were possibly greater (57%) for BA than PL. Results of this study suggest that 1 week of high-dose BA ingestion may enhance the anti-inflammatory response during intense military training, suggesting a potential therapeutic role of BA during intense training.
Studying the Statistics of Natural X-ray Pictures
Authors: Gupta Praful , Glover Jack L. , Paulter Nicholas G. , Bovik Alan C. 
Published: May 2018

AbstractIn this article, we have studied and analyzed the statistics of both pristine and distorted bandpass X-ray images. In the past, we have shown that the statistics of natural, bandpass-filtered visible light (VL) pictures, commonly expressed by natural scene statistic (NSS) models, can be used to create remarkably powerful, perceptually relevant predictors of perceptual picture quality. We find that similar models can be developed that apply quite well to X-ray image data. We have also studied the potential of applying these statistical X-ray NSS models to the design of algorithms for automatic image quality prediction of X-ray images, such as might occur in security, medicine, and material inspection applications. As a demonstration of the discrimination power of these models, we devised an application of NSS models to an image modality classification task, whereby VL, X-ray, infrared, and millimeter-wave images can be effectively and automatically distinguished. Our study is conducted on a dataset of X-ray images made available by the National Institute of Standards and Technology.
GWAS by GBLUP: Single and Multimarker EMMAX and Bayes Factors, with an Example in Detection of a Major Gene for Horse Gait
Authors: Legarra Andres , Ricard Anne , Varona Luis 
Published: May 2018

AbstractBayesian models for genomic prediction and association mapping are being increasingly used in genetics analysis of quantitative traits. Given a point estimate of variance components, the popular methods SNP-BLUP and GBLUP result in joint estimates of the effect of all markers on the analyzed trait; single and multiple marker frequentist tests (EMMAX) can be constructed from these estimates. Indeed, BLUP methods can be seen simultaneously as Bayesian or frequentist methods. So far there is no formal method to produce Bayesian statistics from GBLUP. Here we show that the Bayes Factor, a commonly admitted statistical procedure, can be computed as the ratio of two normal densities: the first, of the estimate of the marker effect over its posterior standard deviation; the second of the null hypothesis (a value of 0 over the prior standard deviation). We extend the BF to pool evidence from several markers and of several traits. A real data set that we analyze, with ours and existing methods, analyzes 630 horses genotyped for 41711 polymorphic SNPs for the trait “outcome of the qualification test” (which addresses gait, or ambling, of horses) for which a known major gene exists. In the horse data, single marker EMMAX shows a significant effect at the right place at Bonferroni level. The BF points to the same location although with low numerical values. The strength of evidence combining information from several consecutive markers increases using the BF and decreases using EMMAX, which comes from a fundamental difference in the Bayesian and frequentist schools of hypothesis testing. We conclude that our BF method complements frequentist EMMAX analyses because it provides a better pooling of evidence across markers, although its use for primary detection is unclear due to the lack of defined rejection thresholds.
Processo civilizador e educação escolar: algumas articulações
Authors: Da Silva Daniele Hungaro , Coelho Marcos Pereira , Montagnoli Gilmar Alves 
Published: May 2018

Embasado nas contribuições de Norbert Elias, este artigo tem como objetivo refletir acerca do caráter civilizador da escola. Para tanto, é inicialmente apresentada uma compreensão da teoria dos processos civilizadores, discussão que possibilita compreender, entre outros assuntos, que costumes e comportamentos, muitas vezes imperceptíveis em ações automatizadas, resultam de todo um processo formativo. A constatação motivou a análise da instituição escolar, a qual desde muito cedo atua no sentido de construir determinados comportamentos no corpo infantil. O pressuposto é que a organização escolar atua de maneira que a subjetividade e a emoção da criança sejam estruturadas de acordo como o adulto estrutura o seu tempo: exigências da vida em sociedade são desde muito cedo formadas no âmbito micro, que é o ambiente escolar, onde o controle das pulsões, aspecto da teoria de Elias, é diariamente praticado, associado a punições, responsabilidades e limites.
RETINOL bINDING PROTEIN AS A MARKER OF CARDIOVASCULAR RISK IN ARTERIAL HYPERTENSION AND ObESITY
Authors: Vasyuk Yu. A. , Sadulaeva I. A. , Yushchuk E. N. , Trofimenko O. S. , Ivanova S. V. 
Published: May 2018

Aim. To assess the influence of retinol-binding protein synthetized by adipose tissue, on clinical course and prognosis of arterial hypertension (AH).Material and methods. Totally, 168 patients included, with AH of 1-3 grade. Study protocol included general clinical investigation (at inclusion, in 1, 4 and 9 months) with analysis of complaints, anamnesis, physical examination, additional laboratory and instrumental methods. In 78 patients among the included, the level of retinolbinding protein RBP4 was measured in blood serum.Results. Increased level of RBP4 correlated significantly with the age, body mass index, duration of AH, raised level of uric acid, pulse wave velocity signs, endogenic nitrite. Only in the group with raised RBP4 there was stroke anamnesis noted, and obesity of III grade. Dynamics of the level of RBP4 during 9 months treatment, depending on cardiometabolic risk, showed some specifics: at inclusion, in the group with high cardiometabolic risk there was significantly increased RBP4 comparing to the groups of patients with low and moderate cardiometabolic risk.Conclusion. Increased level of retinol-binding protein is associated with higher cardiometabolic risk and adverse prognosis.
SPECIFICS OF ARTERIAL HYPERTENSION DEVELOPMENT IN PENITENTIARY STRESS CIRCUMSTANCES
Authors: Dyuzheva E. V. , Ponomarev S. B. 
Published: May 2018

Aim. To reveal the specifics of arterial hypertension (AH) development under the circumstances of penitentiary stress.Material and methods. Totally, 107 patients included, among the persons first time imprisoned, comparable by age and gender — almost healthy young males 25-36 y. o. The relation studied, of psychological test and 24-hour blood pressure (BP) profile and Holter ECG, as heart rate variablity, in three groups of participants formed depending on the duration of imprisonment.Results. It was found that psychoemotional state during the first month of imprisonment is characterized by a high level of situational, personality anxiety with predominant depressive symptomatic. This is followed by heart conduction and rhythm pathology. With the time of imprisonment, level of anxiety and depression declines. Also, heart rhythm variability analysis shows significant decrease of value of LF (%) and predomination of VLF (%) in the wave spectrum. The parameters of 24-hour BP show a significant increase of BP at later periods of imprisonment. Daytime BP level shows direct relation with the parameter “duration of imprisonment”, and nocurnal BP — with the level of situational anxiety.Conclusion. Under the circumstances of penitentiary stress, one of the revealed mechanism of AH development is weakening of sympathetic modulation of vegetative innervation of the heart and decline of baroreflectory sensitivity. Increase of the duration of imprisonment and of the level of situational anxiety are the specific factors of penitentiary circumstances that influence AH development in young clinically healthy men.
THE ROLE OF SYSTEMIC INFLAMMATION IN DECREASE OF ELASTICITY OF MAGISTRAL ARTERIES AND IN PROGRESSION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH SYSTEMIC HYPERTENSION, ObESITY AND TYPE 2 DIAbETES
Authors: Statsenko M. E. , Derevyanchenko M. V. 
Published: May 2018

Aim. To evaluate the role of systemic inflammation in decrease of magistral arteries elasticity and progression of endothelial dysfunction in arterial hypertension (AH) patients comorbid with obesity and/or type 2 diabetes (DM2).Material and methods. Ninety patients with AH stages II-III, 45-65 year old, were selected to 3 groups. Group 1 — patients with “isolated” AH, group 2 — AH with obesity, group 3 — AH and DM2 patients. Standard physical examination was done, vascular stiffness assessment by pulse wave velocity (PWV) measurement of the vessels of muscular (PWVm) and elastic (PWVe) types; the levels were measured of systemic inflammation markers, endothelial dysfunction and fibrosis.Results. PWVe and PWVe >10 m/s were significantly more common in group 3 patients comparing to group 1 (10,3 [9,5;11,7] vs 9,0 [8,0;11,3] m/s and 70 vs 40%, respectively). Concentration of C-reactive protein (CRP) was significantly higher in AH with DM2 comparing to AH and obesity or only AH (7,92 [4,77;16,15] vs 4,77 [4,53;5,43], 7,92 [4,77;16,15] vs 2,98 [0,65;7,19] mg/L, respectively). Level of endothelin-1 (E1) in blood serum increased significantly in 1 to 3 group, with significant differences in all groups. In AH and DM2 patients, concentration of collagen type 4 in the blood was statistically significantly higher than in AH and obesity patients and only AH (5,67 [3,58;9,20] vs 2,94 [2,57;8,45], 5,67 [3,58;9,20] vs 2,63 [2,23;7,28] ng/mL). Correlational analysis showed the presence of highly significant correlations in concentrations of CRP and PWVe (r=0,41), level of E1 (0,51), in E1 and duration of DM2 anamnesis (r=0,58), body mass index (r=0,35), smoking (r=0,54), PWVm (r=0,47), PWVe (r=0,47), in concentration of collagen type 4 and duration of DM2 anamnesis (r=0,36), PWVe (r=0,31). Conclusion. The data obtained witness on the negative influence of systemic inflammation on the elasticity of vascular wall of magistral arteries, and on its importance in progression of endothelial dysfunction in AH patients comorbid with obesity and DM2.
TREATMENT ADHERENCE AND EFFICACY OF ANTIHYPERTENSION TREATMENT IN HYPERTENSIVES IN TYUMENSKAYA ObLAST
Authors: Efanov A. Yu. , Petrov I. M. , Petrova Yu. A. , Vyalkina Yu. A. , Pochinok E. M. , Sholomov I. F. , Medvedeva I. V. , Shalaev S. V. 
Published: May 2018

Aim. To evaluate the impact of treatment adherence on control of arterial hypertension (AH), and within a prospective study, to find out the predictors of adherence decline.Material and methods. Randomly, 321 AH patient selected, from the registry of chronic non-communicable diseases on the territory of Tymenskaya Oblast, visited physician office during year 2014. In analysis of outpatient chart, the prevalence of prescription analyzed, of the groups of antihypertension medications (AHM), including combination drugs. In 3 months (±2,1) after office visit, patients were investigated. The following characteristics were assessed: smoking status, alcohol consumption, comorbidities, economical level, employment, depression and anxiety levels, frequency of AHM intake, prevalence to treatment and BP control efficacy. In 12 months (±2,3) patients, during phone interview, answered the questions on adherence to AHM. The factors revealed, increasing the relative risk (RR) of compliance decline. RR calculated with 95% confidence interval (CI).Results. During a year, decrease of AHM intake found (from 73,2% in 3 months after office visit to 45,2% — in 12 months, р<0,01) and of its efficacy (from 51,9% in 3 months to 41,4% — in 12 months, р<0,01). Compliant to therapy patients reached target levels of BP 3,31 times (2,07-5,31), р<0,01) more often in 3 months after office visit, and 3,39 times (2,09-5,52), р<0,01) — in 12 months. As the predictors of treatment adherence were the following factors: male gender (RR =1,69 (1,06-2,70) p<0,05), age older than 65 (RR =1,72 (1,05-2,81) p<0,05), smoking (RR =1,89 (1,08-3,32) p<0,05), comorbidity 3+ (RR =2,61 (1,48-4,61) p<0,01), overconsumption of alcohol (RR =1,99 (1,02-3,89) <0,05), raised level of depression (RR =1,65 (1,09-2,69) p<0,05), no tonometer at home (RR =1,85 (1,14-2,99) p<0,05), and recommended number of AHM 3 and more (RR =2,96 (1,11-7,85) p<0,05). Higher adherence factors were female gender (RR =0,59 (0,37-0,95) p<0,05), prescription of fixed AHM combinations (RR =0,51 (0,280,923) p<0,05).Conclusion.During the study, we revealed a “patients portrait”, who are under higher chances of lower AHM adherence, and with the maximum effort is needed to retain on the prescribed treatment.
ADDITIONAL ANGIOPROTECTION AND METAbOLIC DISORDERS CORRECTION IN TREATMENT OF ARTERIAL HYPERTENSION PATIENTS REACHED TARGET bLOOD PRESSURE LEVELS, WITH FIxED COMbINATION OF PERINDOPRIL AND INDAPAMIDE
Authors: Nedogod S. V. , Ledyaeva A. A. , Chumachek E. V. , Tsoma V. V. , Salasyuk A. S. , Smirnova V. O. , Khripaeva V. Yu. , Palashkin R. V. , Popova E. A. 
Published: May 2018

Aim. Evaluation of the ability of fixed combination of perindopril and indapamide (Noliprel Bi Forte) to achieve additional angioprotection in patients with arterial hypertension already reached target blood pressure (BP) at previous antihypertension therapy with losartan and hydrochlorothiazide (HCT).Material and methods. To open observational study, lasting 12 weeks, 25 patients included, those who had been taking losartan+HCT 100/12,5 mg. Results. During the study, all patients underwent 24 hour BP monitoring, applanation tonometry (augmentation index assessment and of central BP), measurement of pulse wave velocity (PWV), laboratory tests (lipids, fasting glucose, HOMA index, homocystein, leptin, adiponectin, high-sensitive C-reactive protein (hsCRP), vascular age assessment). After shifting the therapy with losartan and HCT to combination perindopril and indapamide, BP decreased additionally by 3,9%, and diastolic BP — 5,4% (p<0,05). There was decrease of augmentation index by 9,4% and vascular age by 6,0% (p<0,05). There was also decrease of leptin level by 14,5%, hsCRP by 11,0%, and increase of adiponectin by 9,9% (p<0,05).Conclusion. The fixed combination perindopril and indapamide does have advantages for losartan and HCT combination in BP control, vascular elasticity improvement, and facilitates the decrease of body mass index, insulin resistance and non-infectious inflammation.
Как преодолеть отставание России по продолжительности жизни?
Authors: «Демографическое обозрение» Редакция журнала 
Published: May 2018

Материалы Круглого стола, организованного редакцией «Демографического обозрения» совместно с Институтом демографии НИУ ВШЭ. Участники Круглого стола констатируют значительное отставание России от большинства развитых стран по продолжительности жизни, обсуждают новейшие тенденции смертности и продолжительности жизни в России и вопрос об их региональных различиях. Критической оценки заслуживает, по их мнению, современное состояние информации о смертности и заболеваемости населения России. Обсуждаются также половозрастные особенности смертности и изменения в структуре причин смерти в России с 1990 г., рассматривается вопрос о связи тенденций смертности с потреблением алкоголя. Участники Круглого стола обращают внимание на низкую эффективность российской системы здравоохранения и высказывают свои соображения о путях совершенствования этой системы, без чего невозможно преодоление нынешнего российского отставания.
В Круглом столе, проходившем 17 апреля 2015 г., приняли участие ведущие специалисты в области демографии и охраны здоровья:
Е.М. Андреев, к.ф.-м.н., ведущий научный сотрудник Центра демографических исследования Российской экономической школы;
А.Г. Вишневский, д.э.н., директор Института демографии НИУ «Высшая школа экономики»;
С.П. Ермаков, профессор, д.э.н., главный научный сотрудник Института социально-экономических проблем народонаселения РАН, главный научный сотрудник ЦНИИ организации и информатизации здравоохранения Минздрава РФ;
А.Е. Иванова, профессор, д.э.н., заведующий Отделением статистики здоровья населения ЦНИИ организации и информатизации здравоохранения Минздрава РФ;
Е.А. Кваша, к.э.н., старший научный сотрудник Института демографии НИУ «Высшая школа экономики»;
Ю.М. Комаров, профессор, заслуженный деятель науки РФ, д.м.н., член Комитета гражданских инициатив;
Т.Л. Харькова, к.э.н., старший научный сотрудник Института демографии НИУ «Высшая школа экономики»;
С.В. Шишкин, д.э.н., директор Центра политики в сфере здравоохранения «Высшая школа экономики»;
В.М. Школьников, к.г.н., заведующий Лабораторией демографических данных Института демографических исследований общества Макса Планка (Германия).
Демографический дайджест
Authors: Кашницкий Илья Савельевич 
Published: May 2018

Coleman D., S. Basten, F. C. Billari. Population — The long viewBillari F. C. Integrating macro- and micro-level approaches in the explanation of population changeLivi-Bacci M. What we can and cannot learn from the history of World populationKreager P. Population theory — A long viewSear R. Evolutionary contributions to the study of human fertilityReher D. S. Baby booms, busts, and population ageing in the developed worldVan Bavel J., D. S. Reher. The baby boom and its causes: what we know and what we need to knowLutz W., E. Striessnig. Demographic aspects of climate change mitigation and adaptationDemeny P. Sub-replacement fertility in national populations: Can it be raised?Teitelbaum M. S. Political Demography: Powerful trends under-attended by demographic scienceBasten S., Q. Jiang. Fertility in China: an uncertain futureColeman D., S. Basten. The death of the West: An alternative viewBongaarts J., C.Z. Guilmoto. How many more missing women? Excess female mortality and prenatal sex selection, 1970-2050Shon J.-L. P. K., G. Verdugo. Forty years of immigrant segregation in France, 1968-2007. How different is the new immigration?Sobotka T., É. Beaujouan. Two is best? The persistence of a two-child family ideal in EuropeEsping-Andersen G., F. C. Billari. ∙ Re-theorizing family demographicsAnderson T., H.-P. Kohler. Low fertility, socioeconomic development, and genderDoocy S., E. Lyles, T. D. Delbiso, C. W. Robinson, The IOCC/GOPA Study Team. Internal displacement and the Syrian crisis: An analysis of trends from 2011–2014Fakih A., M. Ibrahim. The impact of Syrian refugees on the labor market in neighboring countries: Empirical evidence from JordanBircan T., U. Sunata. Educational assessment of Syrian refugees in TurkeyYaylacı F. G., M. Karakuş. Perceptions and newspaper coverage of Syrian refugees in Turkey
Людские потери в вооруженных конфликтах в мире: 1946-2015 гг.
Authors: Щербакова Екатерина Михайловна 
Published: May 2018

Оценка полных – прямых и косвенных – потерь в результате крупных конфликтов, в значительной степени нарушающих естественное воспроизводство население и порождающих масштабные волны миграции, остается настоятельной задачей для демографов. Важным источником сведений о числе погибших в результате боевых действий и одностороннего насилия являются ежегодно пополняемые базы данных о вооруженных конфликтах. В статье рассматриваются источники данных и оценки смертности в результате организованного коллективного насилия. Проанализированы тенденции изменения числа вооруженных конфликтов разных типов и численности погибших в них за 1946-2015 гг. в целом по миру и крупным регионам, влияние потерь в вооруженных конфликтах на численность населения и его возрастно-половой состав. За период 1946-2015 гг. тяжесть и кровопролитность вооруженных конфликтов снижались, начиная с 2011 г., наметилась тенденция к росту количества конфликтов и числа погибших в них. Растет количество внутренних вооруженных конфликтов, которые впоследствии нередко перерастают в международные с участием многих государств. Но пока сравнение последней четверти века (эпохи после «холодной войны») и предшествующей четверти века свидетельствует о сокращении числа крупных вооруженных конфликтов с участием государства и одностороннего насилия в форме массовых убийств на этнической и политической почве.