bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Exploratory Investigation on the Influence of Practical Experience towards Shaping Future Early Childhood Teachers' Practice in the Arts
Authors: Garvis Susanne 
Published: March 2019

ACCORDING TO THE NATIONAL Education and the Arts Statement (Ministerial Council for Education, Early Childhood Development and Youth Affairs, 2007), all children and young people should have a high-quality arts education. The statement also supports the notion that arts experience can be the first meaningful point of engagement in the education system for students. To achieve quality arts education, teachers require a high level of skill and training (Andrews, 2004). This suggests teachers require significant training to help develop a strong sense of perceived capability towards teaching in the area of arts education. This study explores the beliefs of early childhood teachers in their first three years of teaching. Focusing on self-efficacy beliefs, this study used Bandura's (1997) model of self-regulated learning as a base from which to consider sources of an early childhood teacher's sense of agency related to teaching the arts. Findings suggest teachers develop beliefs about arts education during practical experience that shape attitudes towards teaching arts in the early years. These findings have important messages for improving arts education.
Antioxidant and Antimutagenic Polyisoprenylated Benzophenones and Xanthones from Rheedia acuminata
Authors: Almanza Giovanna R. , Quispe Raúl , Mollinedo Patricia , Rodrigo Gloria , Fukushima Odette , Villagomez Rodrigo , Akesson Bjorn , Sterner Olov 
Published: March 2019

Dichloromethane extract of the stem bark of Rheedia acuminata yielded three benzophenones with antioxidant activity, the new one named acuminophenone A (1), guttiferone K (2) and isoxanthochymol (3), along with the known xanthones formoxanthone C (4) and macluraxanthone (5). The structures were established through interpretation of their spectroscopic data, the stereochemistry of compounds (1) and (2) were resolved by experimental and computational experiments and their antioxidant activities were measured using the DPPH, ABTS and TEAC assays. The antioxidant results showed that metabolites 1, 4 and 5 had a better antioxidant activity than the reference compound quercetin. In addition, we evaluate the mutagenicity and antimutagenicity of the CH2Cl2 extract as well as of the free radical scavenger compounds 1, 4 and 5 by the AMES Salmonella/microsomal test. No mutagenicity was found in the CH2Cl2 extract using Salmonella typhimurium strains TA98, TA100, TA102, TA1537 and TA1538, with or without S9 metabolic activation. The pure compounds neither showed mutagenicity in TA 102 strain and the most important result was the strong reduction of mutagenic effect induced by hydrogen peroxide in S. typhimurium TA 102, with or without S9, showed by the compounds 1 (more than 93%) and 4 (more than 88%) at 0.02 μg/plate.
Chemical Composition and Biological Activity of the Volatile Extracts of Achillea millefolium
Authors: Falconieri Danilo , Piras Alessandra , Porcedda Silvia , Marongiu Bruno , Gonçalves Maria J. , Cabral Célia , Cavaleiro Carlos , Salgueiro Ligia 
Published: March 2019

In this study, flowering aerial parts of wild Achillea millefolium growing on the Mediterranean coast (Sardinia Island, Italy) and on the Atlantic coast (Portugal- Serra de Montemuro) were used as a matrix for supercritical extraction of volatile oil with CO2 (SFE). The collected extracts were analyzed by GC-FID and GC-MS methods and their composition were compared with that of the essential oil isolated by hydrodistillation. A strong chemical variability in essential oils depending on the origin of the samples was observed. The results showed the presence of two type oils. The Italian volatile extracts (SFE and essential oil) are predominantly composed by α-asarone (25.6-33.3%, in the SFE extract and in the HD oil, respectively), β-bisabolene (27.3-16.6%) and α-pinene (10.0-17.0%); whereas the main components of the Portuguese extracts are trans-thujone (31.4-29.0%), trans-crhysanthenyl acetate (19.8-15.8%) and β-pinene (1.2-11.1%). The minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida albicans, C. tropicalis, C. krusei, C. guillermondii, C. parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, T. mentagrophytes, T. mentagrophytes var. interdigitale, T. verrucosum, Microsporum canis, M. gypseum, Epidermophyton floccosum, Aspergillus niger, A. fumigatus and A. flavus. The oils showed the highest activity against dermatophyte strains, with MIC values ranging from 0.32-1.25 μL mL−1.
A high prevalence of chronic gastrointestinal symptoms in adults with cystic fibrosis is detected using tools already validated in other GI disorders
Authors: Hayee Bu’Hussain , Watson Kerry-Lee , Campbell Sanchika , Simpson Anna , Farrell Emma , Hutchings Penelope , Macedo Patricia , Perrin Felicity , Whelan Kevin , Elston Caroline 
Published: March 2019

BackgroundPeople with cystic fibrosis (CF) report a variety of gastrointestinal (GI) symptoms, independent of pancreatic enzyme insufficiency (PEI), reminiscent of other chronic GI disorders. There are currently no accepted or validated assessment tools and neither the range, frequency nor severity of GI symptoms has been systematically described in CF. We present results of a cross‐sectional study using established tools and compare them to current measures of quality of life (QOL).MethodsConsecutive patients attending specialist CF appointments were asked to complete questionnaires including the GI Symptom Rating Scale (GSRS); Irritable Bowel Syndrome Symptom Severity Score (IBS‐SSS) and Cystic Fibrosis Questionnaire (CFQ‐R). Questionnaire terminology was altered to replace references to ‘IBS’ with ‘GI symptoms’.ResultsIn total, 107 patients were recruited (mean age, 27.8 ± 9.6 years; 60 female), and 94 (88%) had PEI. Body mass index was 22.1 ± 3.6 kg/m2, forced expiratory volume in one second was 59 + 27.7% predicted. Fifty‐three (49.5%) were p.Phe508del homozygous. Overall 69/107 (65%) reported significant GI symptoms independent of PEI or adherence to pancreatic enzyme replacement therapy (PERT), with the four most frequent being attributable to the lower GI tract: bloating/distension, flatulence, abdominal pain and borborygmi (gurgling). There was no numerical correlation between any CFQ‐R domain (particularly Digestion domain) and GSRS or SSS.ConclusionThis is the first systematic study measuring GI symptoms in CF using validated GI tools. Symptoms are not related to PERT or genotype and appear to be captured well by the GSRS. Further research will study longitudinal changes with treatment, and therapeutic trials in CF may use these tools to demonstrate a positive impact on ‘non‐respiratory’ symptoms and QOL.
Cortical Bone Trajectory Screws for Fixation Across the Cervicothoracic Junction: Surgical Technique and Outcomes
Authors: Obeidat Mohammad , Tan Zachary , Finkelstein Joel A. 
Published: March 2019

Study Design: Clinical case series describing a novel surgical technique. Objective: Stabilization across the cervicothoracic junction (CTJ) poses technical difficulties which make this procedure challenging. The transition from cervical lordosis to thoracic kyphosis and the orientation of the lateral masses of the cervical spine compared with the pedicles of the thoracic spine create the need to accommodate for 2 planes of alignment when placing instrumentation. A novel surgical technique for instrumentation across the cervicothoracic junction is described. Methods: The use of cortical bone trajectory (CBT) technique for pedicle fixation in the upper thoracic spine is described in combination with cervical lateral mass or pedicle screws. The application in our first 12 patients for stabilization across the CTJ is described. Two case presentations illustrate the technique. Results: All the patients had rod screw constructs without the need to skip levels, there was no requirement for transverse connectors and only 1 plane of contouring was required. Conclusions: The use of CBT technique has not been described for the upper thoracic spine. This technique avoids many technical problems associated with posterior instrumentation of the CTJ. The facility of their use in this application arises from the similar coronal plane entry points as the cervical lateral mass screws compared with the more lateral starting point of traditional thoracic pedicle screws. The technique has clinical equipoise to traditional thoracic pedicle screw insertion but with the benefits of an easier ability to perform the instrumentation and saving levels of fusion.
Defined conditions for propagation and manipulation of mouse embryonic stem cells
Authors: Mulas Carla , Kalkan Tüzer , von Meyenn Ferdinand , Leitch Harry G. , Nichols Jennifer , Smith Austin 
Published: March 2019

ABSTRACT
The power of mouse embryonic stem (ES) cells to colonise the developing embryo has revolutionised mammalian developmental genetics and stem cell research. This power is vulnerable, however, to the cell culture environment, deficiencies in which can lead to cellular heterogeneity, adaptive phenotypes, epigenetic aberrations and genetic abnormalities. Here, we provide detailed methodologies for derivation, propagation, genetic modification and primary differentiation of ES cells in 2i or 2i+LIF media without serum or undefined serum substitutes. Implemented diligently, these procedures minimise variability and deviation, thereby improving the efficiency, reproducibility and biological validity of ES cell experimentation.
Multiparametric MRI-guided dose boost to dominant intraprostatic lesions in CT-based High-dose-rate prostate brachytherapy
Authors: Wang Tonghe , Press Robert H. , Giles Matt , Jani Ashesh B. , Rossi Peter , Lei Yang , Curran Walter J. , Patel Pretesh , Liu Tian , Yang Xiaofeng 
Published: March 2019

Objective:
The purpose of this study is to investigate the dosimetric feasibility of delivering focal dose to multiparametric (mp) MRI-defined DILs in CT-based high-dose-rate (HDR) prostate brachytherapy with MR/CT registration and estimate its clinical benefit.

Methods:
We retrospectively investigated a total of 17 patients with mp-MRI and CT images acquired pre-treatment and treated by HDR prostate brachytherapy. 21 dominant intraprostatic lesions (DILs) were contoured on mp-MRI and propagated to CT images using a deformable image registration method. A boost plan was created for each patient and optimized on the original needle pattern. In addition, separate plans were generated using a virtually implanted needle around the DIL to mimic mp-MRI guided needle placement. DIL dose coverage and organ-at-rick (OAR) sparing were compared with original plan results. Tumor control probability (TCP) was estimated to further evaluate the clinical impact on the boost plans.

Results:
Overall, optimized boost plans significantly escalated dose to DILs while meeting OAR constraints. The addition of mp-MRI guided virtual needles facilitate increased coverage of DIL volumes, achieving a V150 &gt; 90% in 85 % of DILs compared with 57 % of boost plan without an additional needle. Compared with original plan, TCP models estimated improvement in DIL control by 28 % for patients with external-beam treatment and by 8 % for monotherapy patients.

Conclusion:
With MR/CT registration, the proposed mp-MRI guided DIL boost in CT-based HDR brachytherapy is feasible without violating OAR constraints, and indicates significant clinical benefit in improving TCP of DIL. It may represent a strategy to personalize treatment delivery and improve tumor control.

Advances in knowledge:
This study investigated the feasibility of mp-MRI guided DIL boost in HDR prostate brachytherapy with CT-based treatment planning, and estimated its clinical impact by TCP and NTCP estimation.
Case Report: Paradoxical acrodermatitis of Hallopeau-like eruption following anti-IL-17 therapy
Authors: Tadiotto Cicogna Giulia , Messina Francesco , Nalotto Linda , Szekely Serena , Alaibac Mauro 
Published: March 2019

Psoriasis is a chronic immune-mediated inflammatory disease. Up to 40% of patients with psoriasis may develop psoriatic arthritis. Currently, interleukin (IL)-17/IL-23 pathways are identified as key factors in the immunopathogenesis of both conditions. Here we describe the case of a patient who developed psoriasiform skin lesions 10 months after the initiation of anti-IL17 therapy for psoriatic arthritis. The underlying disease had responded well to the therapy, but the patient developed a striking pustular eruption at the fingers with nail involvement, onycholysis, yellow discoloration, and subungual keratosis. Clinical and histological findings were consistent with an acrodermatitis continua of Hallopeau-like eruption. Skin lesions subsided after discontinuation of the responsible anti-IL17 agent. The interpretation of this paradoxical side effect of biological therapies remains unclear but may relate to an unbalanced inflammatory cytokine response induced by the inhibition of TNF activity. It is likely that patients, who are genetically prone, may respond exaggeratedly to a cytokine imbalance. The identification of this kind of patient, in the future, could be useful in order to choose the correct therapy.
TÜRKÇE ÖĞRETMENLERİNİN METİN İŞLEME SÜRECİNDE KULLANDIKLARI GERİBİLDİRİM TÜRLERİNE YÖNELİK BİR ARAŞTIRMA
Authors: GÖÇER Ali , ŞENTÜRK Rahime 
Published: March 2019

Bu
araştırmanın amacı, Türkçe öğretmenlerinin ders
işleyiş sürecinde kullandıkları geribildirim türlerini ortaya koyarak süreçte
verilebilecek geribildirim türleri ile ilgili farkındalık oluşturmaktır. Çalışmada nitel
araştırma yaklaşımı çerçevesinde görüşme, gözlem ve doküman inceleme yöntemleri
kullanılmıştır. Araştırma, Kayseri ve Samsun illerinde görevli Türkçe
öğretmeninden oluşturulan 28 kişilik bir çalışma grubu üzerinden yürütülmüştür.
Çalışma grubu, amaçlı ve kümeleme örnekleme yöntemleri tercih edilerek
oluşturulmuştur. Araştırmada
incelenen veriler iki sorulu yarı yapılandırılmış görüşme formu ile elde
edilmiş ve betimsel analizi yapılmıştır. Gözlem formu ile elde edilen veriler
ise içerik analizi tekniğiyle öğretmenin öğrenci soru ve cevaplarına verdiği
geribildirimler, etkinliklerle ilgili olarak konu anlatımı sürecinde ve dersin
sonunda verdiği geribildirimler, öğretmenin öğrenciye ilişkin verdiği
geribildirimler ile akranların geribildirim verme durumları ulamlarına yönelik
incelenmiş kod ve temalar ile geribildirimin alt ulamları belirtilmiştir. Elde
edilen sonuçlara göre, bölge farketmeksizin Türkçe öğretmenleri daha çok bütün sınıfa yönelik değerlendirmeci ve sözel geribildirim vermekle birlikte
betimleyici, sürece dayalı ve yazılı geribildirim türlerini daha az
kullanmaktadırlar. Türkçe öğretmenlerinin metin işleme sürecinde geribildirim
vermenin önemine ilişkin görüş birliği sağlandığı ancak hangi beceri alanına ne
zaman, nasıl ve hangi türde geribildirim verilebileceği ile ilgili konularda
sorun yaşadıkları tespit edilmiştir.
Perbedaan Antara Parasetamol dan Ketolorak Terhadap Kadar Substansi Serum Tikus Wistar Sebagai Analgesik
Authors: Hidayat Agus Purwo , Harahap Mohamad Sofyan , Villyastuti Yulia Wahyu 
Published: March 2019

Latar Belakang:Analgesik preemptif merupakan intervensi analgesik yang dimulai sebelum stimulasi noksius muncul dalam hubungannya dengan blok perifer maupun nosisepsi sentral. Tujuanannya untuk menurunkan nyeri akut pasca trauma jaringan, mencegah modulasi nyeri pada SSP dan mencegah terjadinya nyeri kronis. Elemen penting dalam proses persepsi nyeri adalah substansi P dimana Fungsi sensoris substansi P diperkirakan berkaitan dengan transmisi informasi nyeri ke sistem saraf pusat. Parasetamol dan ketorolak sebagai obat anti-inflamasi non steroid dengan efek antipiretik dan analgetik. Berperan dalam menghambat enzim siklooksigenase. Hal ini diharapkan dapat mengetahui perbedaan kadar substansi P tikus wistar pada keduanya sebagai pilihan analgesik preemptif. Tujuan: Mengetahui perbedaan efektivitas antara Parasetamol dan Ketorolak yang dinilai dari kadar Substansi P pada tikus Wistar sebagai analgesik preemptif. Metode: Penelitian ini merupakan eksperimental laboratorik dengan disain Rondomize Pre and Post test control group design. Sejumlah 21 ekor tikus, dibagi menjadi tiga kelompok yang dilakukan secara acak masing-masing terdiri dari 7 ekor tikus untuk kelompok kontrol (K), 7 ekor tikus untuk kelompok perlakuan parasetamol atau K(1), 7 ekor tikus untuk kelompok perlakuan ketorolak atau K(2). Setelah adaptasi selama 7 hari, tikus-tikus dari kelompok perlakuan maupun kontrol dilakukan pembiusan dengan menggunakan ketamin. Satu jam sebelum pembiusan, kelompok K (1) diberi injeksi paracetamol 18 mg intravena dan kelompok K(2) diberi injeksi ketorolak 0,54 mg intravena. Sesudah terbius, bulu di sekitar punggung dicukur bersih dan didesinfeksi menggunakan betadine. Selanjutnya dibuat irisan sepanjang 2 cm dan kedalaman sampai subkutan. Luka irisan dibersihkan dan dioles larutan betadine, kemudian luka ditutup dengan lima jahitan tunggal sederhana menggunakan benang side. Selanjutnya jahitan dibersihkan, diolesi betadin dan dirawat. Paska pembedahan juga diberikan penisilin oil 15 mg. Pengambilan sampel darah untuk pemeriksaa kadar Substansi P dilakukan pada kelompok K, K(1) dan K(2) 1 jam sebelum pemberian parasetamol dan ketorolak, dan pada jam ke-4 setelah dilakukan insisi pada tikus wistar.Hasil: Dilakukan perlakuan terhadap tikus wistar, terdapat 2 ekor yang drop out, sehingga jumlah sampel yang dianalisa sebanyak 30 sampel. Pada Uji Mann-Whitney kadar substansi P dalam kelompok parasetamol dibandingkan dengan kelompok ketorolak dibentuk secara signifikan berbeda (p = 0,016; p <0,005), sedangkan kadar substansi P kelompok Parasetamol ditemukan lebih rendah dari kelompok ketorolak.Kesimpulan: Pemberian parasetamol sebagai analgesik preemptif dapat menurunkan kadar substansi P pada tikus model Wistar yang lebih signifikan dibandingkan dengan ketorolak.
Evaluation of bond strength of cross-laminated LSL specimens under short-span bending
Authors: Gong Meng , Li Ling , Chui Ying-Hei 
Published: March 2019

Abstract
Mass timber panels (MTPs) have a great potential in the construction of mid- and high-rise buildings. Evaluation of the face-bond strength of MTPs is of great practical interest for this kind of products. This study aimed at developing an appropriate test procedure for evaluating the adhesive bond strength of cross-laminated laminated strand lumber (CL-LSL). Three-point short-span bending tests were conducted on two-layer asymmetric CL-LSL specimens (2LasymCL-LSL), which were adhesively bonded by two-component resins of the type polyurethane (PUR) or polyvinyl acetate (PVAc). For comparison, block shear specimens were tested as well. It was found that the 2LasymCL-LSL assembly was better suitable under the short-span bending for differentiating between good and poor bond quality of MTPs.
Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules
Authors: Mahringer Anne , Bernd Alexandra , Miller David S. , Fricker Gert 
Published: March 2019

Abstract
Many widespread and persistent organic pollutants, for example, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and some polychlorinated biphenyls, activate the aryl hydrocarbon receptor (AhR) causing it to translocate to the cell nucleus where it transactivates target genes, increasing expression of a number of xenobiotic metabolizing enzymes as well as some transporters. AhR’s ability to target transporters within the kidney is essentially unexplored. We show here that exposing isolated killifish (Fundulus heteroclitus) renal proximal tubules to micromolar β-naphthoflavone (BNF) or nanomolar TCDD roughly doubled the transport activity of Multidrug resistance-associated proteins Mrp2 and Mrp4, P-glycoprotein (P-gp) and Breast cancer resistance protein (Bcrp), all ATP-driven xenobiotic efflux pumps and critical determinants of renal xenobiotic excretion. These effects were abolished by actinomycin D and cycloheximide and by the AhR antagonist, α-naphthoflavone, indicating that increased transport activity was dependent on transcription and translation as well as ligand binding to AhR. Quantitative immunostaining of renal tubules exposed to BNF and TCDD showed increased luminal membrane expression of Mrp2, Mrp4, P-gp and Bcrp. Thus, in these renal tubules, the four ABC transporters are targets of AhR action.
Mg2+ homeostasis and transport in cyanobacteria – at the crossroads of bacterial and chloroplast Mg2+ import
Authors: Pohland Anne-Christin , Schneider Dirk 
Published: March 2019

Abstract
Magnesium cation (Mg2+) is the most abundant divalent cation in living cells, where it is required for various intracellular functions. In chloroplasts and cyanobacteria, established photosynthetic model systems, Mg2+ is the central ion in chlorophylls, and Mg2+ flux across the thylakoid membrane is required for counterbalancing the light-induced generation of a ΔpH across the thylakoid membrane. Yet, not much is known about Mg2+ homoeostasis, transport and distribution within cyanobacteria. However, Mg2+ transport across membranes has been studied in non-photosynthetic bacteria, and first observations and findings are reported for chloroplasts. Cyanobacterial cytoplasmic membranes appear to contain the well-characterized Mg2+ channels CorA and/or MgtE, which both facilitate transmembrane Mg2+ flux down the electrochemical gradient. Both Mg2+ channels are typical for non-photosynthetic bacteria. Furthermore, Mg2+ transporters of the MgtA/B family are also present in the cytoplasmic membrane to mediate active Mg2+ import into the bacterial cell. While the cytoplasmic membrane of cyanobacteria resembles a ‘classical’ bacterial membrane, essentially nothing is known about Mg2+ channels and/or transporters in thylakoid membranes of cyanobacteria or chloroplasts. As discussed here, at least one Mg2+ channelling protein must be localized within thylakoid membranes. Thus, either one of the ‘typical’ bacterial Mg2+ channels has a dual localization in the cytoplasmic plus the thylakoid membrane, or another, yet unidentified channel is present in cyanobacterial thylakoid membranes.
Study of the Drying Rate and Colour Kinetics during Stepwise Air-Drying of Apricot Halves
Authors: Xanthopoulos G. , Athanasiou A. , Sempou A. , Lentzou D. , Templalexis Ch. , Boudouvis A.G. 
Published: March 2019

AbstractThe drying rate and colour kinetics of apricot halves were studied during stepwise air-drying compared to continuous drying. The tested stepwise temperature profiles exhibited two successive falling rate periods, which differed from the drying rate period of the constant drying temperature profile. Three chromatic indices, namely browning index, chroma and hue were analysed. The analysis showed that treatment with ascorbic acid was more effective during the step up temperature profile, whilst its antioxidant activity was lost during the step down temperature profile due to the initially used high drying temperatures. The chromatic indices were described by a modified kinetic model, the parameters of which were estimated by theLevenberg–Marquardtoptimization algorithm and in all cases was derived R2adj≥ 0.88 and MRD < 4.88%.