bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immobilization following Distal Radius Fractures: A Randomized Clinical Trial
Authors: Hill J. , Bouz Gabriel , Azad Ali , Pannell William , Alluri R. , Ghiassi Alidad , Navo Paul 
Published: August 2018

Background No consensus exists regarding postoperative splinting position following volar plate fixation of distal radius fractures.
Purpose The purpose of this study was to determine whether immobilization in supination would result in superior outcomes compared with no restriction of forearm range of motion.
Patients and Methods All patients >18 years of age with distal radius fractures indicated for volar plate fixation were eligible. Exclusion criteria were open fracture and concomitant injury to, or functional deficit of, either upper extremity. Patients were randomized to immobilization in (1) maximal supination with a sugar-tong splint or (2) no restriction of supination with a volar splint. Patient-Rated Wrist Evaluation (PRWE), Disabilities of the Arm, Shoulder, and Hand (DASH) score, and visual analog scale (VAS) score; wrist range of motion; and grip strength were recorded at 2 and 6 weeks postoperatively. A Student's t-test was used to compare mean values of all outcome measures at each time point.
Results A total of 46 patients enrolled in the study; 28 were immobilized with a volar splint and 18 were immobilized with a sugar-tong splint. Six-week follow-up data were obtained for 32 patients. There was no significant difference in PRWE, DASH, and VAS scores; or range of motion; or grip strength between the two groups postoperatively.
Conclusion Range of motion, grip strength, and patient-rated outcome measures were similar regardless of postoperative immobilization technique in patients with a distal radius fractures stabilized with a volar plate. Surgeons can elect to use the standard-of-care postoperative immobilization modality of their preference following volar plate fixation without compromising short-term return to function.
Level of Evidence This is a Level II, therapeutic study.
Minimally Invasive Plate Osteosynthesis for Extra-articular Distal Radius Fracture in Postmenopausal Women: Longitudinal versus Transverse Incision
Authors: Galmiche Chloé , Rodríguez Gustavo , Xavier Fred , Igeta Yuka , Hidalgo Diaz Juan , Liverneaux Philippe 
Published: August 2018

Background This work aimed to compare two mini-invasive palmar approaches (longitudinal and transverse) to osteosynthesize fractures of the distal radius. The main hypothesis was that the longitudinal technique gave smaller incisions. The secondary hypothesis was that the longitudinal technique would be better for the recovery of pain, functional scores, strength, and mobility.
Materials and Methods The series included 30 extra-articular distal radius fractures in 30 patients (average age: 74 years) fixed with volar locking plate using a mini-invasive technique. Fifteen of these patients had a single longitudinal surgical approach (Group I), and 15 had a transverse approach that was completed with a longitudinal incision for the proximal screws (Group II).
Results The combined average incision size was 14.73 mm in Group I and 19.8 mm in Group II. After 6 months, the pain was on average 1.4/10 (Group I) and 0.46/10 (Group II), the quick Disability of the Arm, Shoulder, and Hand was 13.63/100 (Group I) and 2.8/100 (Group II), Patient-Related Wrist Evaluation was 11.8/100 (Group I) and 5.97/100 (Group II), grip strength was 81.06% (Group I) and 72.13% (Group II), flexion was 88.13% (Group I) and 75% (Group II), extension was 86% (Group I) and 64.6% (Group II), ulnar inclination was 89% (Group I) and 78.67% (Group II), radial inclination was 89.73% (Group I) and 79.93% (Group II), pronation was 96.67% (Group I) and 81.46% (Group II), and supination was 91.93% (Group I) and 79.87% (Group II).
Clinical Relevance The longitudinal technique gave smaller incisions than the transverse technique. Among the secondary hypotheses, all the variables were better with the longitudinal technique, except the pain, although without any significant difference.
Arthroscopic Treatment of Translunate Perilunate Injuries, Not Dislocated (PLIND)
Authors: Herzberg Guillaume , Cievet-Bonfils Maxime , Burnier Marion 
Published: August 2018

Background Translunate perilunate dislocations were recently described as well as perilunate injuries, not dislocated (PLIND). The authors present a case of transradial styloid, translunate PLIND which sustained a full arthroscopic reduction and internal fixation.
Case Description A 33-year-old man sustained a transradial styloid, translunate PLIND due to a fall from a truck with his wrist in hyperextension. The diagnosis was made at the acute stage. Full arthroscopic reduction and internal fixation with Kirschner wires was performed, followed by a 6 weeks' immobilization period. Uneventful healing of both the lunate and radial styloid were observed at 6 weeks and confirmed with a computed tomography scan. At 4 years of follow-up, the Lyon wrist score was 78% (good).
Literature Review Very few lunate fractures are described in the literature. Translunate perilunate dislocations were recently described as well as PLIND. To the best of the authors' knowledge, a case of transradial styloid, translunate PLIND which sustained a full arthroscopic reduction and internal fixation has never been reported so far.
Clinical Relevance This case reports a unique pattern of transradial styloid, translunate PLIND and outlines the usefulness of a full arthroscopic treatment. An open reduction for this pattern of injury would have been extensive, difficult, and probably unreliable.
Survival Rate on a 10-Year Follow-Up of Total Wrist Replacement Implants: A 23-Patient Case Series
Authors: Honecker Sophie , Igeta Yuka , Al Hefzi Ali , Pizza Chiara , Facca Sybille , Liverneaux Philippe 
Published: August 2018

Background According to current literature, the estimated average survival rate for Remotion, the total wrist implants, is above 90% on an 8-year follow-up. We examined our series of Remotion to calculate its survival rate on a 10-year follow-up.
Case Description A total of 23 cases of total wrist implants were reviewed. The case series included 22 patients, 18 females and 4 males, of an average age of 55 years. The case series included 19 inflammatory rheumatic diseases, 3 Kienböck disease, and 1 posttraumatic arthrosis.
Conclusion The average survival rate of our case series was 95.7% on a 4-year follow-up, 91.3% on a 6-year follow-up, and 69% on a 10-year follow-up. On our review, the QuickDASH score, pain, wrist extension range of motion, and grip strength were improved postoperatively. No difference was shown between preoperative and postoperative values for wrist flexion, pronation, and supination. The case series included a septic case, treated by arthrodesis, and three total wrist implants displacements, two of which were treated by carpal implant, and the remaining one was treated by arthrodesis.
Clinical Relevance The survival rate of the total wrist replacement implant Remotion was estimated to be 69%.
Quantum control of phase fluctuations in semiconductor lasers
Authors: Santis Christos T. , Vilenchik Yaakov , Satyan Naresh , Rakuljic George , Yariv Amnon 
Published: August 2018

Significance
The semiconductor laser, arguably the most versatile member of the family of lasers, has become a technological staple of a massively interconnected, data-driven world, with its spectral purity (i.e., temporal coherence) an increasingly important figure of merit. The present work describes a conceptually fundamental “recipe” for the enhancement of coherence, predicated on direct control of the coherence-limiting process itself, the field–matter interaction. As such, it is inherently adaptable and technologically scalable. As photonic materials and fabrication techniques continue to improve, the described approach has the potential of serving as a roadmap for major and sustained improvements in coherence. With experimentally demonstrated coherence limited at 1 kHz in this work, we envision “deep” sub-kilohertz-level coherence to be soon within reach.
iTOP: inferring the topology of omics data
Authors: Aben Nanne , Westerhuis Johan A , Song Yipeng , Kiers Henk A L , Michaut Magali , Smilde Age K , Wessels Lodewyk F A 
Published: August 2018

Abstract

Motivation
In biology, we are often faced with multiple datasets recorded on the same set of objects, such as multi-omics and phenotypic data of the same tumors. These datasets are typically not independent from each other. For example, methylation may influence gene expression, which may, in turn, influence drug response. Such relationships can strongly affect analyses performed on the data, as we have previously shown for the identification of biomarkers of drug response. Therefore, it is important to be able to chart the relationships between datasets.

Results
We present iTOP, a methodology to infer a topology of relationships between datasets. We base this methodology on the RV coefficient, a measure of matrix correlation, which can be used to determine how much information is shared between two datasets. We extended the RV coefficient for partial matrix correlations, which allows the use of graph reconstruction algorithms, such as the PC algorithm, to infer the topologies. In addition, since multi-omics data often contain binary data (e.g. mutations), we also extended the RV coefficient for binary data. Applying iTOP to pharmacogenomics data, we found that gene expression acts as a mediator between most other datasets and drug response: only proteomics clearly shares information with drug response that is not present in gene expression. Based on this result, we used TANDEM, a method for drug response prediction, to identify which variables predictive of drug response were distinct to either gene expression or proteomics.

Availability and implementation
An implementation of our methodology is available in the R package iTOP on CRAN. Additionally, an R Markdown document with code to reproduce all figures is provided as Supplementary Material.

Supplementary information
Supplementary data are available at Bioinformatics online.
Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients
Authors: Crépin Thomas , Legendre Mathieu , Carron Clémence , Vachey Clément , Courivaud Cécile , Rebibou Jean-Michel , Ferrand Christophe , Laheurte Caroline , Vauchy Charline , Gaiffe Emilie , Saas Philippe , Ducloux Didier , Bamoulid Jamal 
Published: August 2018

Abstract

Background
Patients with chronic kidney disease (CKD) are more prone to develop premature age-related diseases. Data on immune senescence are scarce in CKD populations, except in end-stage renal disease and dialysis. We designed a longitudinal prospective study to evaluate immune senescence at different CKD stages and its influence on CKD patient outcomes.

Methods
Clinical and biological data collections were performed on 222 patients at different CKD stages [1–2 (n = 85), 4 (n = 53) and 5 (n = 84)]. Immune senescence biomarkers were measured by cytometry on T cells (CD28, CD57, CD45RA, CD31, γH2A.X) or by quantitative polymerase chain reaction [relative telomere length (RTL)] on peripheral blood mononuclear cells and analysed according to CKD stages and outcomes.

Results
CKD was associated with an increase in immune senescence and inflammation biomarkers, as follows: low thymic output (197 ± 25 versus 88 ± 13 versus 73 ± 21 CD4+CD45RA+CD31+ T cells/mm3), an increased proportion of terminally differentiated T cells (CD8+CD28−CD57+) (24 ± 18 versus 32 ± 17 versus 35 ± 19%) restricted to cytomegalovirus-positive patients, telomere shortening (1.11 ± 0.36 versus 0.78 ± 0.24 versus 0.97 ± 0.21 telomere:single copy ratio) and an increase in C-reactive protein levels [median 2.9 (range 1.8–4.9) versus 5.1 (27–9.6) versus 6.2 (3.4–10.5) mg/L]. In multivariate analysis, shorter RTL was associated with death {hazard ratio [HR] 4.12 [95% confidence interval (CI) 1.44–11.75]}. Low thymic output was associated with infections [HR 1.79 (95% CI (1.34–9.58)] and terminally differentiated CD8+ T-cell expansion with a risk of cardiovascular events [CEs; HR 4.86 (95% CI 1.72–13.72)].

Conclusion
CKD was associated with premature immune ageing. Each of these alterations increased the risk of specific age-related diseases, such as RTL and death, thymic function and infections and terminally differentiated CD8+ T-cell expansion and CEs.
Double Blinded Randomized Trial of Subcutaneous Trigeminal Nerve Stimulation as Adjuvant Treatment for Major Unipolar Depressive Disorder
Authors: Gorgulho Alessandra A , Fernandes Fernando , Damiani Lucas P , Barbosa Daniel A N , Cury Abrão , Lasagno Camila M , Bueno Priscila R T , Santos Bruno F O , Santos Renato H N , Berwanger Otávio , Cavalcanti Alexandre B , Teixeira Manoel J , Moreno Ricardo A , De Salles Antonio A F 
Published: August 2018

Abstract

BACKGROUND
More than 30% of major depressive disorder patients fail to respond to adequate trials of medications and psychotherapy. While modern neuromodulation approaches (ie, vagal nerve stimulation, deep brain stimulation) are yet to prove their efficacy for such cases in large randomized controlled trials, trigeminal nerve stimulation (TNS) has emerged as an alternative with promising effects on mood disorders.

OBJECTIVE
To assess efficacy, safety, tolerability, and placebo effect duration of continuous subcutaneous TNS (sTNS) in treatment-resistant depression (TRD).

METHODS
The TREND study is a single-center, double-blind, randomized, controlled, phase II clinical trial. Twenty unipolar TRD patients will receive V1 sTNS as adjuvant to medical therapy and randomized to active vs sham stimulation throughout a 24-wk period. An additional 24-wk open-label phase will follow. Data concerning efficacy, placebo response, relapse, and side effects related to surgery or electrical stimulation will be recorded. We will use the HDRS-17, BDI-SR, IDS_SR30, and UKU scales.

EXPECTED OUTCOMES
The main outcome measure is improvement in depression scores using HAM-17 under continuous sTNS as adjuvant to antidepressants. Active stimulation is expected to significantly impact response and remission rates. Minor side effects are expected due to the surgical procedure and electrical stimulation. The open-label phase should further confirm efficacy and tolerability.

DISCUSSION
This study protocol is designed to define efficacy of a novel adjuvant therapy for TRD. We must strive to develop safe, reproducible, predictable, and well-tolerated neuromodulation approaches for TRD patients impaired to manage their lives and contribute with society.
Far Lateral Craniotomy for Posterior Inferior Cerebellar Artery–Posterior Inferior Cerebellar Artery Bypass and Trapping of Posterior Inferior Cerebellar Artery Aneurysm: 3-Dimensional Operative Video
Authors: Gandhi Sirin , Mascitelli Justin , Hardesty Douglas , Lawton Michael T 
Published: August 2018

Abstract
Posterior inferior cerebellar artery (PICA) aneurysms account for 3% to 4% of all intracranial aneurysms with an unusually high predilection towards a nonsaccular morphology making microsurgical clipping or endovascular reconstruction of the parent artery difficult. The management of these complicated aneurysms may require revascularization procedures for flow preservation with aneurysm trapping. Recently, there is an increasing inclination towards intracranial–intracranial (IC-IC) bypasses over traditional extracranial donors.
This video demonstrates a side-to-side PICA–PICA in situ bypass with trapping of an unruptured incidental right p1-PICA aneurysm. Radiological lesion progression and presence of dysplastic morphological characteristics prompted surgical management. The aneurysm was not amenable to clip reconstruction due to the dysplastic PICA segment and lack of a discernable neck. Institutional Review Board approval and patient consent were sought. With patient in three-quarter-prone position, a right far lateral craniotomy was performed. A left-to-right p3-p3 PICA bypass was completed. The aneurysm was clipped along with proximal PICA at its takeoff from vertebral artery. Indocyanine green videoangiography revealed complete occlusion of aneurysm and proximal PICA and a patent anastomosis with distal right PICA flow. Postoperatively, patient recovered with no new neurological deficits.
Dolichoectatic posterior circulation aneurysms are not readily amenable to clip reconstruction. PICA–PICA in situ bypass is an elegant alternative to existing extracranial–intracranial revascularization constructs (occipital artery to PICA).
1
There is lower neurological morbidity associated with IC-IC bypass vs PICA reimplantation due to the deep surgical corridor and its proximity to lower cranial nerves. Additionally, in this patient endovascular occlusion posed a higher risk of thrombotic complications and postprocedural cerebellar edema with brainstem compression.
2
Recanalization of Acute Common Carotid Artery Occlusion: 2-Dimensional Operative Video
Authors: Sorenson Thomas J , Cloft Harry , Rabinstein Alejandro , Lanzino Giuseppe 
Published: August 2018

Abstract
While revascularization of the acutely or chronically occluded internal carotid artery has become commonplace with modern endovascular techniques, revascularization of an acutely occluded common carotid artery (CCA) is a controversial procedure with unique challenges. These challenges can be related to the lack of observable markers for identifying vessels during navigation or for identifying the exact location and extent of occlusion within the CCA, in addition to wide-ranging treatment risks. In this video, we illustrate the controversial revascularization of a 68-yr-old woman with an acute CCA occlusion who presented with fluctuating neurological symptoms. We believed treatment to be indicated by the lack of adequate collaterals on the intracranial CTA, and fluctuating symptoms in the absence of an intracranial major vessel occlusion, suggesting that the CCA occlusion was exerting important hemodynamic effects and at risk of causing a major stroke without revascularization, despite a low initial NIH stroke score. Though acute recanalization of patients with low NIH stroke score with stent-angioplasty is a controversial procedure, we believed it to be necessary in the case of our patient and believe it will likely be the focus of the next wave of large clinical trials dedicated to acute stroke.
THE GERMAN DOSE RATE MONITORING NETWORK AND IMPLEMENTED DATA HARMONIZATION TECHNIQUES
Authors: Stöhlker U , Bleher M , Doll H , Dombrowski H , Harms W , Hellmann I , Luff R , Prommer B , Seifert S , Weiler F 
Published: August 2018

Abstract
Environmental radiation monitoring networks have been established in Europe and world-wide for the purpose of protecting population and environment against ionizing radiation. Some of these networks had been established during the cold war period and were improved after the Chernobyl accident in 1986. Today, the German Federal Office for Radiation Protection (BfS) operates an early warning network with roughly 1800 ambient dose equivalent rate (ADER) stations equally distributed over the German territory. The hardware and software of all network components are developed in-house allowing the continuous optimization of all relevant components. A probe characterization and quality assurance and control program are in place. Operational and technical aspects of the network and data harmonization techniques are described. The latter allows for calculating of the terrestrial and net ADER combined with uncertainties mainly from site specific effects. Harmonized data are finally used as input to the German emergency management system and the European radiological data exchange platform.
Neural symptoms in a gene knockout mouse model of Sjögren‐Larsson syndrome are associated with a decrease in 2‐hydroxygalactosylceramide
Authors: Kanetake Tsukasa , Sassa Takayuki , Nojiri Koki , Sawai Megumi , Hattori Satoko , Miyakawa Tsuyoshi , Kitamura Takuya , Kihara Akio 
Published: August 2018

ABSTRACTInsulation by myelin lipids is essential to fast action potential conductivity: changes in their quality or amount can cause several neurologic disorders. Sjögren‐Larsson syndrome (SLS) is one such disorder, which is caused by mutations in the fatty aldehyde dehydrogenase ALDH3A2. To date, the molecular mechanism underlying SLS pathology has remained unknown. In this study, we found that Aldh3a2 is expressed in oligodendrocytes and neurons in the mouse brain, and neurons of Aldh3a2 knockout (KO) mice exhibited impaired metabolism of the long‐chain base, a component of sphingolipids. Aldh3a2 KO mice showed several abnormalities corresponding to SLS symptoms in behavioral tests, including increased paw slips on a balance beam and light‐induced anxiety. In their brain tissue, 2‐hydroxygalactosylceramide, an important lipid for myelin function and maintenance, was reduced by the inactivation of fatty acid 2‐hydroxylase. Our findings provide important new insights into the molecular mechanisms responsible for neural pathogenesis caused by lipid metabolism abnormalities.—Kanetake, T., Sassa, T., Nojiri, K., Sawai, M., Hattori, S., Miyakawa, T., Kitamura, T., Kihara, A. Neural symptoms in a gene knockout mouse model of Sjögren‐Larsson syndrome are associated with a decrease in 2‐hydroxygalactosylceramide. FASEB J. 33, 928–941 (2019). www.fasebj.org
Pro‐ and antiangiogenic therapies: current status and clinical implications
Authors: Rust Ruslan , Gantner Christina , Schwab Martin E. 
Published: August 2018

ABSTRACTBlood vessels nurture every part of the human body. Consequently, abnormalities in the vasculature are closely associated with a variety of diseases, including cerebral stroke, heart disease, retinopathy, and cancer. Pro‐ or antiangiogenic therapies can influence these diseases by regulating the growth of new blood vessels from a pre‐existing vascular network or dampening excessive blood growth. However, clinical translation of these approaches is slow and challenging. In this review, we discuss recent preclinical approaches to regulate angiogenesis and their potential and risks in a clinical setting.—Rust, R., Gantner, C., Schwab, M. E. Pro‐ and antiangiogenic therapies: current status and clinical implications. FASEB J. 33, 34–48 (2019). www.fasebj.org
The State of the Science on Clinical Evaluation in Nursing Education
Authors: Lewallen Lynne P. , Van Horn Elizabeth R. 
Published: August 2018

Abstract

AIM
The purpose was to synthesize the published evidence to present the state of the science in clinical evaluation research in nursing education.

BACKGROUND
Clinical evaluation is key to ensuring nursing students’ clinical competence, application of knowledge, and critical thinking, all of which are important to patient safety and quality nursing care.

METHOD
Cooper’s research synthesis method was used.

RESULTS
A comprehensive literature search resulted in 250 documents, of which 88 met study criteria. Topics were exhaustive but not mutually exclusive and included competence, instrumentation, congruence, teaching methods, objective structured clinical evaluation, faculty/preceptor issues with clinical evaluation, essential clinical behaviors, topic-based evaluation, decision-making about clinical grade, and clinical reasoning.

CONCLUSION
Nursing education science is in its infancy in many areas. Two areas most in need of future research are the need to accurately define and efficiently measure competence in the clinical area and the need for reliable and valid instrumentation.