bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review article: Myopia - Genetically inherited or environmental influences
Authors: Tjoa S E E , Putra S E D 
Published: July 2019

Abstract
Myopia or nearsightedness is a condition in which a person cannot see distant objects clearly. It is currently the most common eye disorder. It is predicted that half of the world’s population will develop myopia by 2050. Myopia has been associated with both environmental and genetic influences affecting eye growth. The mechanism by which genetics can lead to myopia is still uncertain. Much remains to be elucidated about the interplay between environmental and genetic factors that play a role in the onset of myopia. The main purpose of this article is to describe molecular (genetic and epigenetic) and environmental (lifestyle influenced) causes of myopia in order that drugs, therapies, and other treatments can be found to cure and prevent myopia. As the conclusion, a picture of interconnectivity between genetic, environment, and myopia was constructed
Developmental effect of cashew nut shell extract against nymphal instar of Silver leaf Whitefly (Bemisia tabaci Genn.)
Authors: Andayanie W R , Ermawati N 
Published: July 2019

Abstract
Cashew nut shell (CNS), which are one of the most still is tropical biomass waste. This study was aimed to test mortality rates of CNS extract against the first to third instar nymphs of Silverleaf Whitefly (Bemisia tabaci Genn.1889). The concentration of CNS extract were: 0.22 %, 0.67 %, 2.00 %, 6.00 %. The LC50 and LC90 values indicated that CNS extract at concentration of 2.00 % were the most toxic compound to the first instar stage followed by CNS extract at concentration of 6.00 %, 0.67 %, imidacloprit, and CNS at concentration of 0.22 %, respectively. The concentration of 6.00 % showed the most toxic effect to the second stage followed by CNS extract at concentration of 2.00 %, 0.67 %, imidacloprit, and CNS at concentration of 0.22 %, respectively. The lethal concentration (LC50−90) value of the CNS extract at concentration of 6.00 %, at concentration of 2.00 %, 0.67 %, imidacloprit, CNS extract at concentration of showed the toxicity against the third instar nymph. This CNS extract at concentration of 2.00 % could be used to suppress of the B. tabaci nymphs of different stages (first to third instar) and negative effect of phytotoxicity on the soybean leaves.
Identification of a local variety of ‘uwi’ (Dioscorea alata Linn.) in four agro-climate regions of East-West Java - Indonesia based on tuber character
Authors: Wuryantoro  , Puspitawati I R , Fitriyani R I , Soni P 
Published: July 2019

Abstract
Indonesia is very well known for its genetic diversity of potential tubers plants for alternative and functional food sources. ‘Uwi’ (Dioscorea alata Linn.) as one of the tuber’s plants needs to get attention, so there is no genetic erosion or even extinction. Seeing the high diversity of agro-climates and the high genetic diversity of ‘uwi’ plants, it is necessary to mapping and identify the suitability of the ‘uwi’ plant in line with its agro-climate character. The study aims to identify specific local varieties and the distribution of other types with broad adaptability. The analysis using the similarity interval function on the NTSys program showed that of the 47 accessions tested at 70 % similarity level there were four groups scattered in four different agro-climates. The first group enters climate types C2, C3 and B2; the second group enters C2; the third group enters C2 and C3; all fourth enter C2, C3, D3. Found three specific accession only in type C2 and C3 and most of the ‘uwi’ plants have distribution in all types of climates, showing broad adaptability and potential to be developed without high technology. The colours, shapes, flavours, and feathers of the tubers are the main differentiators in existing diversity.
Application of blood donor routine detector using K-Nearest neighbors
Authors: Nurdiansyah Y , Pandunata P , Prasetyo N D , Trihartono A , Putrianti F G , Wijayanto F 
Published: July 2019

Abstract
The application of blood donor routine detection using the K-nearest Neighbors method at UTD PMI (Unit Transfusi Darah, Palang Merah Indonesia, Indonesian Red Cross, Hereafter PMI) is a system that aims to provide the class status of the donors aimed at facilitating the employee in selecting the right donor to be recontacted. The K-Nearest Neighbors method is used to calculate the distance of the test data with the training data. The K-nearest Neighbors method is chosen because it has a simple algorithm, works based on the shortest distance from the test data sample to the training data sample to determine the distance. The creation of this system is built by adapting the waterfall model. The objective is that the system is able to implement the K-nearest Neighbors method to help determine the class status of the donors and that the system can send SMS gateway to the donors that donor information can be publicly published. The test calculation uses full train full set testing on all training data and the result of K5=84 %, K7=88 %, K9=87 %, K11=82 %, K13=77 %, K15=75 %. The highest result is on the K7.
Identification of the bacterium isolate from Mackerel Fish (Rastrelliger sp.) using 16S rRNA Gene
Authors: Ismail Y S , Febriani  , Yulvizar C , Ramadhani R 
Published: July 2019

Abstract
The use of probiotics in aquaculture can improve the quality and quantity of the fishes. One of potential probiotic bacterium from gastrointestine of mackerel fish (Rastrelliger sp.) isolated in this research were LUI-04. This study aimed to determine the species of bacterium isolate using nucleotide sequence homology compared to other microorganisms in GenBank. The 16S rRNA genes of LUI-04 isolate were analyzed. The results of electrophoresis showed the DNA band had a size of 1 500 bp for amplification using Bact-27F and Uni-1492R primers, and about 250 bp to 500 bp with the Com-IF and Com-2R primers. The sequence of nucleotides was determined by Sanger method. The 16S rRNA sequence of the isolate and other bacteria in GenBank were compared with the Basic Alignment Search Tool (BLAST) to know the homology. Then, all of the sequences were aligned by ClustalW, and the phylogenetic tree was reconstructed with Neighbor Joining method using bootstrap analysis of 1 000 replicates. The results showed that LUI-04 had a homology of 99 % and the bootstrap value percentage of 86 % with Bacillus aryabhattai B8W22 and four strains of Bacillus megaterium (strain QM B1551, NBRC15308, strain IAM 13418 and ATCC 14581). Therefore, the LUI-04 isolate belongs to Bacillus megaterium species.
Socioeconomic Status Moderates the Effects of Health Cognitions on Health Behaviors within Participants: Two Multibehavior Studies
Authors: Schüz Benjamin , Brick Cameron , Wilding Sarah , Conner Mark 
Published: July 2019

AbstractBackgroundSocioeconomic differences in health-related behaviors are a major cause of health inequalities. However, the mechanisms (mediation/moderation) by which socioeconomic status (SES) affects health behavior are a topic of ongoing debate.PurposeCurrent research on SES as moderator of the health cognitions–health behavior relation is inconsistent. Previous studies are limited by diverse operationalizations of SES and health behaviors, demographically narrow samples, and between-person designs addressing within-person processes. This paper presents two studies addressing these shortcomings in a within-person multibehavior framework using hierarchical linear models.MethodsTwo online studies, one cross-sectional and one 4 week longitudinal, assessed 1,005 (Study 1; Amazon MTurk; USA only) and 1,273 participants (Study 2; Prolific; international). Self-reports of multiple SES indicators (education, income, occupation status; ZIP code in Study 1), health cognitions (from the theory of planned behavior), and measures of six health behaviors were taken. Multilevel models with cross-level interactions tested whether the within-person relationships between health cognitions and behaviors differed by between-person SES.ResultsEducation significantly moderated intention-behavior and attitude-behavior relationships in both studies, with more educated individuals showing stronger positive relationships. In addition, ZIP-level SES (Study 1) moderated attitude-behavior effects such that these relationships were stronger in participants living in areas with higher SES.ConclusionsEducation appears to be an important resource for the translation of intentions and attitudes into behavior. Other SES indicators showed less consistent effects. This has implications for interventions aiming at increasing intentions to change health behaviors, as some interventions might inadvertently increase health inequalities.
Progesterone promotes embryo adhesion by upregulating c-Fos/c-Jun transcription factor-mediated poFUT1 expression†
Authors: Cui Xinyuan , Sun Jiaqi , Liang Caixia , Zheng Qin , Yang Xuesong , Liu Shuai , Yan Qiu 
Published: July 2019

Abstract
The proliferation and adhesion abilities of placental trophoblasts are critical for embryo implantation and successful pregnancy. Protein O-fucosyltransferase 1 (poFUT1) and the transcription factor c-Fos/c-Jun have been found to promote trophoblastic cell invade into the endometrium. Progesterone is critical to the regulation of embryonic implantation. However, the exact role of poFUT1 in embryo proliferation and adhesion to the endometrium, and the relationship between progesterone, c-Fos/c-Jun, and poFUT1 has not been studied in detail. In the current study, we found that the serum levels of poFUT1 and progesterone significantly was decreased in miscarriage patients compared with those in normal pregnancy women, and there is a positive correlation between the changes in progesterone and poFUT1. Employing a human embryo trophoblastic cell line (JAR), we showed that progesterone facilitated the activation of c-Fos/c-Jun. Using an electrophoretic mobility shift assay and chromatin immunoprecipitation, we confirmed that the specific transcription factor c-Fos/c-Jun regulated the poFUT1 promoter, which could enhance poFUT1 transcriptional activity, thus further increasing trophoblast cell proliferation and adhesion potential. Taking these findings together, progesterone upregulates poFUT1 expression via the specific transcription factor c-Fos/c-Jun, and then increase trophoblast cell proliferation and adhesion potential. poFUT1 and progesterone may be used together as potential markers of miscarriage, and they may be diagnostic and therapeutic targets for miscarriage.
‘All Knowledge Begins with the Senses’1: Towards a Sensory Criminology
Authors: McClanahan Bill , South Nigel 
Published: July 2019

AbstractVisual criminology has established itself as a site of criminological innovation. Its ascendance, though, highlights ways in which the ‘ocularcentrism’ of the social sciences is reproduced in criminology. We respond, arguing for attention to the totality of sensorial modalities. Outlining the possible contours of a criminology concerned with smell, taste, sound and touch—along with the visual—the paper describes moments in which the sensory intersects with various phenomena of crime, harm, justice and power. Noting the primacy of the sensorial in understanding environmental harm, we describe an explicitly sensory green criminology while also suggesting the ways that heightened criminological attention to the non-visual senses might uncover new sites and modes of knowledge and a more richly affective criminology.
N-cadherin (Cdh2) Maintains Migration and Postmitotic Survival of Cortical Interneuron Precursors in a Cell-Type-Specific Manner
Authors: László Zsófia I , Bercsényi Kinga , Mayer Mátyás , Lefkovics Kornél , Szabó Gábor , Katona István , Lele Zsolt 
Published: July 2019

AbstractThe multiplex role of cadherin-based adhesion complexes during development of pallial excitatory neurons has been thoroughly characterized. In contrast, much less is known about their function during interneuron development. Here, we report that conditional removal of N-cadherin (Cdh2) from postmitotic neuroblasts of the subpallium results in a decreased number of Gad65-GFP-positive interneurons in the adult cortex. We also found that interneuron precursor migration into the pallium was already delayed at E14. Using immunohistochemistry and TUNEL assay in the embryonic subpallium, we excluded decreased mitosis and elevated cell death as possible sources of this defect. Moreover, by analyzing the interneuron composition of the adult somatosensory cortex, we uncovered an unexpected interneuron-type-specific defect caused by Cdh2-loss. This was not due to a fate-switch between interneuron populations or altered target selection during migration. Instead, potentially due to the migration delay, part of the precursors failed to enter the cortical plate and consequently got eliminated at early postnatal stages. In summary, our results indicate that Cdh2-mediated interactions are necessary for migration and survival during the postmitotic phase of interneuron development. Furthermore, we also propose that unlike in pallial glutamatergic cells, Cdh2 is not universal, rather a cell type-specific factor during this process.
Post-treatment cephalometric changes in adolescent patients with Class II malocclusion treated using two different functional appliance systems for an extended time period: a randomized clinical trial
Authors: DiBiase Andrew T , Lucchesi Luisa , Qureshi Usman , Lee Robert T 
Published: July 2019

Summary

Objectives
To assess the post-treatment changes in Class II adolescent patients treated with two different functional appliances for an extended time period.

Design
Randomized clinical trial.

Setting
One university and one district general hospital in the UK.

Participants
Caucasian adolescent patients with a Class II malocclusion.

Methods
Pairs of patients of similar age and gender were randomly allocated to one of two functional appliance systems, the Twin Block or Dynamax appliance. The appliances were used for 15 months full time. Changes were measured from lateral cephalograms taken at the start (T1) and at the end of treatment at 15 months (T2) and 30 months (T3).

Results
Hundred patients completed the trial, 52 Twin Block and 48 Dynamax. Mandibular forward movement was 3.5 mm (±2.5) in the Twin Block group and 1.7 mm (±2.1) in the Dynamax group (P &lt; 0.01; T1–T2) and, subsequently, by 0.3 mm (±2.6) and 0.9 mm (±2.5), respectively (P = 0.3; T2–T3). Mandibular length increased by 6.3 mm (±2.7) in the Twin Block group and 4.0 mm (±2.5) in the Dynamax group (P &lt; 0.01; T1–T2) with treatment and, subsequently, by 0.5 mm (±2.3) and 1.5 mm (±3.1; P = 0.05). Anterior face height increased in both groups.

Conclusions
Treatment resulted in greater mandibular growth with the Twin Block than the Dynamax. In the follow-up period, there was less growth in the Twin Block group compared to the Dynamax

Trial Registration
This trial was not registered on any major database of clinical trial.

Protocol
The protocol was not published before the commencement of the trial but can be given on request.
Nutritional and economic impact of five alternative front-of-pack nutritional labels: experimental evidence
Authors: Crosetto Paolo , Lacroix Anne , Muller Laurent , Ruffieux Bernard 
Published: July 2019

AbstractAn incentivised laboratory framed field experiment with 691 subjects examined the impact of five front-of-pack labels (Multiple Traffic Lights; Reference Intakes; HealthStarRating; NutriScore and Système d’Etiquetage Nutritionnel Simplifié) on food shopping within a catalogue of 290 products. Using difference-in-difference, we estimate the between-label variability of within-subject changes in the shopping’s Food and Standards Agency aggregated nutritional score. All labels improve the nutritional quality (−1.56 FSA points on average). NutriScore is the most effective (−2.65), followed by HealthStarRating (−1.86). Behaviourally, subjects react mostly to the extreme values of the labels and not to intermediate values. Nutritional gains are not correlated with higher expenditure.
Cellulosomes localise on the surface of membrane vesicles from the cellulolytic bacterium Clostridium thermocellum
Authors: Ichikawa Shunsuke , Ogawa Satoru , Nishida Ayami , Kobayashi Yuzuki , Kurosawa Toshihito , Karita Shuichi 
Published: July 2019

ABSTRACT
Membrane vesicles released from bacteria contribute to cell–cell communication by carrying various cargos such as proteins, nucleic acids and signaling molecules. Cellulolytic bacteria have been isolated from many environments, yet the function of membrane vesicles for cellulolytic ability has been rarely described. Here, we show that a Gram-positive cellulolytic bacterium Clostridium thermocellum released membrane vesicles, each approximately 50–300 nm in diameter, into the broth. The observations with immunoelectron microscopy also revealed that cellulosomes, which are carbohydrate-active enzyme complexes that give C. thermocellum high cellulolytic activity, localized on the surface of the membrane vesicles. The membrane vesicles collected by ultracentrifugation maintained the cellulolytic activity. Supplementation with the biosurfactant surfactin or sonication treatment disrupted the membrane vesicles in the exoproteome of C. thermocellum and significantly decreased the degradation activity of the exoproteome for microcrystalline cellulose. However, these did not affect the degradation activity for soluble carboxymethyl cellulose. These results suggest a novel function of membrane vesicles: C. thermocellum releases cellulolytic enzymes on the surface of membrane vesicles to enhance the cellulolytic activity of C. thermocellum for crystalline cellulose.
EPPO perspective on Agrilus planipennis (Emerald Ash Borer) and Agrilus anxius (Bronze Birch Borer)
Authors: Petter F , Orlinski A , Suffert M , Roy A S , Ward M 
Published: July 2019

Abstract
One of the main aims of EPPO is to help its member countries to prevent entry or spread of dangerous pests (plant quarantine). The Organization has therefore been given the task of identifying pests which may present a risk (early warning/horizon scanning), evaluating their risk for the region and making proposals on the phytosanitary measures which can be taken against them (Pest Risk Analysis). Standards are also developed, including standards on how to eradicate and control pests. In addition to the development of Standards, activities on communication and citizen science (development of guidelines on raising public awareness and the production of toolkits to use in raising awareness campaigns) have also recently been started. The EPPO Secretariat was alerted by the National Plant Protection Organization (NPPO) of Sweden in 2003, and Norway in 2010, to two potential new pests, Emerald ash borer (EAB), Agrilus planipennis (Fairmaire) and Bronze birch borer, Agrilus anxius (Gory) respectively. Because of the importance of these two pests for forest species in the EPPO region, member countries agreed that EPPO recommendations should be prepared. The different EPPO activities relevant to A. planipennis and A. anxius are presented, highlighting the challenges they currently pose to the region.
Box, stalked, and upside-down? Draft genomes from diverse jellyfish (Cnidaria, Acraspeda) lineages: Alatina alata (Cubozoa), Calvadosia cruxmelitensis (Staurozoa), and Cassiopea xamachana (Scyphozoa)
Authors: Ohdera Aki , Ames Cheryl L , Dikow Rebecca B , Kayal Ehsan , Chiodin Marta , Busby Ben , La Sean , Pirro Stacy , Collins Allen G , Medina Mónica , Ryan Joseph F 
Published: July 2019

Abstract

Background
Anthozoa, Endocnidozoa, and Medusozoa are the 3 major clades of Cnidaria. Medusozoa is further divided into 4 clades, Hydrozoa, Staurozoa, Cubozoa, and Scyphozoa—the latter 3 lineages make up the clade Acraspeda. Acraspeda encompasses extraordinary diversity in terms of life history, numerous nuisance species, taxa with complex eyes rivaling other animals, and some of the most venomous organisms on the planet. Genomes have recently become available within Scyphozoa and Cubozoa, but there are currently no published genomes within Staurozoa and Cubozoa.

Findings
Here we present 3 new draft genomes of Calvadosia cruxmelitensis (Staurozoa), Alatina alata (Cubozoa), and Cassiopea xamachana (Scyphozoa) for which we provide a preliminary orthology analysis that includes an inventory of their respective venom-related genes. Additionally, we identify synteny between POU and Hox genes that had previously been reported in a hydrozoan, suggesting this linkage is highly conserved, possibly dating back to at least the last common ancestor of Medusozoa, yet likely independent of vertebrate POU-Hox linkages.

Conclusions
These draft genomes provide a valuable resource for studying the evolutionary history and biology of these extraordinary animals, and for identifying genomic features underlying venom, vision, and life history traits in Acraspeda.
Incidence and characteristics of left atrial appendage stumps after device-enabled epicardial closure
Authors: Caliskan Etem , Eberhard Matthias , Falk Volkmar , Alkadhi Hatem , Emmert Maximilian Y 
Published: July 2019

Abstract

OBJECTIVES
High success rates for left atrial appendage (LAA) exclusion with the AtriClip (Atricure, USA) device have been reported in the literature. This study evaluated the presence and characteristics of residual LAA stumps after AtriClip LAA exclusion using postoperative short- and long-term computed tomography angiography (CTA).

METHODS
In this retrospective analysis, 43 of 291 consecutive patients undergoing cardiac surgery with concomitant LAA occlusion using the AtriClip device were identified with available postoperative short- and long-term follow-up by CTA. LAA patency and the absence or the size of a present residual LAA stump were assessed on 2-dimensional multiplanar reconstructions, on maximum intensity projection images and on volume-rendered 3-dimensional computed tomography reconstructions. Based on current recommendations, the threshold for a significant LAA stump length was defined <10 mm.

RESULTS
The LAA was successfully occluded in all 43 patients (100%) as confirmed by intraoperative transoesophageal echocardiography and CTA imaging with a mean follow-up duration of 7.1 ± 0.8 years post-implant. The absence of blood flow in the excluded LAA was confirmed in all cases. In 31 of 43 patients (72%), no residual stump (0 mm) was observed creating a smooth endocardial surface, CTA revealed residual LAA stumps in 11/43 patients (26%) with a length <10 mm and a significant residual stump with a depth of >10 mm (12 mm) in 1 patient (2%). The mean length, width and depth of the residual stumps were 5.8 ± 2.1, 4.4 ± 1.2 and 7.3 ± 2.3 mm, respectively.

CONCLUSIONS
This study investigated the incidence of residual stump formation (>10 mm) after LAA closure with the AtriClip device based on CTA imaging data obtained during short- and long-term follow-up. While no LAA stump was detectable in the majority of patients, a non-significant LAA stump (<10 mm) was present in 26% of cases, indicating a favourable LAA occlusion profile for the AtriClip device. However, although a LAA stump length <10 mm is currently considered clinically safe, this definition needs further attention in future studies with regards to its potential clinical implications.