bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the hidden culprit: How the brain-gut axis fuels neuroinflammation in ischemic stroke
Authors: Ma Brian D. Y. , Chan Travis Y. H. , Lo Benjamin W. Y. 
Published: October 2024

Background:
The brain-gut axis represents a bidirectional communication network between the gut microbiome and the central nervous system that plays an important role in homeostasis. Compelling evidence now confirms that ischemic stroke disrupts this delicate balance by inducing gut dysbiosis.

Methods:
A comprehensive literature search was performed in PubMed, Web of Science, and Google Scholar for articles published between January 2000 and January 2023 using relevant keywords. Studies were limited to English and included original studies, literature, and systematic reviewers from peer-reviewed journals which discussed gut microbiota composition in models/subjects with ischemic stroke or assessed stroke impact on gut microbiota. Comments, meeting abstracts, and case reports were excluded. From the 80 relevant articles, we summarized key findings related to gut microbiota changes after stroke and their association with stroke outcomes.

Results:
Emerging preclinical evidence underscores the pivotal role of the gut microbiome in glial cell development and function. Germ-free models exhibit compromised microglial activation and impaired cellular debris clearance, exacerbating tissue damage following ischemic stroke. Targeted interventions, including prebiotics, probiotics, and fecal microbiota transplantation, have demonstrated efficacy in rescuing glial phenotypes in preclinical stroke models. Beyond its local effects, the gut microbiome significantly influences systemic immunity. Ischemic stroke polarizes pro-inflammatory phenotypes of neutrophils and T cells, amplifying neurovascular inflammation. Microbiota manipulation modulates leukocyte trafficking and metabolic signaling, offering potential avenues to mitigate infarct pathology.

Conclusion:
Our review demonstrates that in preclinical stroke models, modulating the lipopolysaccharide, short-chain fatty acid, and trimethylamine N-oxide pathways through the gut-brain axis reduces infarct sizes and edema and improves functional recovery after ischemic stroke. Further exploration of this important axis may unveil additional adjunctive stroke therapies by elucidating the complex interplay between the microbiome and the brain. Rigorously controlled clinical studies are now warranted to translate these promising preclinical findings and investigate whether manipulating the microbiome-brain relationship can help improve outcomes for stroke patients. Overall, continued research on the gut-brain axis holds exciting possibilities for developing novel treatment strategies that may enhance recovery after stroke.
Neurocircle microsurgery model: Description of simulation-based training and exoscope
Authors: Yataco-Wilcas Christian Alexander , Lengua-Vega Luis Alberto , Coasaca-Tito Yosimar Salomon , Diaz-Llanes Bruno Eduardo , Salazar-Campos Cristian Eugenio 
Published: October 2024

Background:
Microsurgery is crucial in neurosurgery, requiring precise skills for interventions on delicate structures. Effective training is essential for developing these skills. In Peru and Latin America, however, there is a notable shortage of specialized training centers and high costs associated with foreign simulators, hindering the development of neurosurgical skills. To address this issue, the NeuroZone3D Research Center has initiated a project to create a national dataset on Peruvian craniometry and develop locally adapted training models.

Methods:
The “NeuroCircle Microsurgery Model” was created through a multi-phase process. Phase 1 involved designing a simulation platform using a 3D printer. Phase 2 focused on creating a realistic biomodel with polyurethane and advanced modeling techniques. In Phase 3, the biomodel was assembled and integrated into the platform. Phase 4 included using a wooden module, a cost-effective exoscope simulation, and surgical instruments to provide a realistic training environment.

Results:
The “NeuroCircle Microsurgery Model” provided a stable and effective training environment. Feedback from training sessions with neurosurgery residents and medical students indicated significant improvements in microsurgical skills. Participants valued the model’s realism and its role in enhancing their surgical proficiency.

Conclusion:
The “NeuroCircle Microsurgery Model” is a significant advancement in microsurgery training for Peru and Latin America. Its development provides a valuable, locally adaptable tool for improving surgical skills and addresses the critical training gaps in the region.
Research on Blended Learning Mode of College English based on the Chaoxing Learning Platform
Authors: Ran Ran 
Published: October 2024

College English is one of the public courses in many majors in universities. Traditional teaching often adopts the traditional large class approach, with face-to-face teaching between teachers and students. In the context of the development of the Internet, online courses have begun to rise. In addition to the influence of many objective factors, online teaching mode has been favored by many schools. At present, applying the information technology teaching mode to subject teaching has become a trend. This article focuses on college English courses and researches the blended learning mode under the application of the Chaoxing Learning Platform to improve teaching efficiency.
Digital transformation in waste management: Enhancing financial transaction efficiency at a waste bank
Authors: Kristiyanti Dinar Ajeng , Permana Angga Aditya , Saputri Fahmy Rinanda , Johan Monika Evelin , Shabrina Nabila Husna , Hartono Kevin Aditya , Pranoto Ray Anthony 
Published: October 2024

Waste management poses a serious global challenge. Indonesia, as one of the world's largest waste producers, faces significant impacts from this issue. At Bank Sampah Pamulang 25, manual transaction recording has been a major problem leading to various difficulties and data inaccuracies. To address this, the Community Partnership Program (PKM) was implemented focusing on developing the Waste Bank Financial Information System (SIKEBAS) to enhance efficiency and productivity. The research method used was Community-Based Participatory Research (CBPR), involving collaboration between local communities, students, and lecturers. Through a series of activities, the SIKEBAS website was successfully developed to automate waste and financial data recording and management. Evaluation of the implementation results showed a significant improvement in efficiency and productivity among Bank Sampah Pamulang 25 staff. Initially, 88.9 percent of participants did not understand the use of technology in transaction recording at the waste bank. However, after socialization, 75 percent of participants strongly agreed and 25 percent agreed that the SIKEBAS website facilitated the transaction process. Thus, the development of the web-based information system SIKEBAS has proven to be an effective solution to address the challenges of manual waste management.
Training on producing eucalyptus and betel leaf oil for dengue fever prevention
Authors: Yuniartika Wachidah , Mangifera Liana , Porusia Mitoriana , Ananta Dyaz Surya , Alea Zuan Nun , Hanifah Aisyah Dani 
Published: October 2024

Dengue Hemorrhagic Fever (DHF) remains a significant public health issue in Indonesia and is endemic in nearly all provinces. The mortality rate from DHF continues to rise each year. To address this, health education on dengue fever prevention is essential. One preventive measure involves the use of natural ingredients. Betel leaves, in particular, can kill mosquito larvae due to the toxic substances they contain, which are especially harmful to mosquito larvae. Therefore, community service activities are necessary to raise awareness and provide practical solutions. This activity was conducted in Jetis Village, Sukoharjo, targeting 30 women in the Family Welfare Program (PKK) from the local community. The implementation included the preparation of pre-tests and post-tests, as well as training sessions. The questionnaire used in this activity assessed participants' skills through a pretest, followed by training in making eucalyptus and betel leaf oil, and concluded with a post-test. The results showed a significant improvement in the participants' skills, with most moving from "moderately competent" to "competent," as indicated by a P-value of 0.001. It can be concluded that the oil-making training effectively improved the skills of the PKK women.
Wardrop Optimal Networks
Authors: Kalampakas Antonios 
Published: October 2024

Optimal flow allocation in directed networks is often analyzed through two types of equilibria. The first, called user equilibrium, occurs when the travel times on all utilized routes are the same and shorter than every unused route. The second, called system optimum, minimizes the average travel time across all routes. These two concepts represent the optimality for individual users and for the network as a whole, respectively, and generally do not coincide. This paper introduces and examines networks where user equilibrium and system optimum are identical, termed Wardrop Optimal Networks. Moreover, we illustrate that these flows remain consistent under several important transformations as well as under uniform changes in their latency functions.
Some Generator Subgraphs of the Square of a Cycle
Authors: Mame Realiza 
Published: October 2024

Graphs considered in this paper are finite simple graphs, which has no loops and multiple edges. Let $G= (V(G),E(G))$ be a graph with $E(G) = \{e_{1}, e_{2},\ldots, e_{m}\},$ for some positive integer $m.$ The \textit{edge space} of $G,$ denoted by $\mathscr{E}(G),$ is a vector space over the field $\zn_{2}.$ The elements of $\mathscr{E}(G)$ are all the subsets of $E(G)$. Vector addition is defined as $X+Y = X ~\Delta~ Y,$ the symmetric difference of sets $X$ and $Y,$ for $X,Y \in \mathscr{E}(G).$ Scalar multiplication is defined as $1\cdot X =X$ and $0 \cdot X = \emptyset$ for $X \in \mathscr{E}(G).$ Let $H$ be a subgraph of $G.$ The \textit{uniform set of $H$} with respect to $G,$ denoted by $E_{H}(G),$ is the set of all elements of $\mathscr E(G)$ that induces a subgraph isomorphic to $H.$ The subspace of $\mathscr E(G)$ generated by $E_{H}(G)$ shall be denoted by $\mathscr E_{H}(G).$ If $E_H(G)$ is a generating set, that is $\mathscr E_{H}(G)= \mathscr E(G),$ then $H$ is called a \textit{generator subgraph} of $G.$ This paper determines some generator subgraphs of the square of a cycle. Moreover, this paper established sufficient conditions for the generator subgraphs of the square of a cycle.
Telaah Hubungan Tongkonan dan Lanskap Budaya Toraja: Analisis Sistem Aktivitas dan Ekspresi Sistem Setting
Authors: Ramma Zwasty Paskahlia , Hayati Arina , Cahyadini Sarah 
Published: October 2024

Tongkonan, as vernacular architecture, cannot be dissociated from its cultural landscape. Tongkonan and its cultural landscape form a holistic entity that constitutes Toraja culture as a whole. However, most current research focuses solely on Tongkonan’s architectural and structural aspects. There are still few studies that explore Tongkonan’s vernacular architecture in connection with its cultural landscape, including its relationship to the culture of its people and its geographical context. This research is a desk study with the aim of formulating aspects related to further examining the relationship between Tongkonan as vernacular architecture and its cultural landscape based on theory of systems of activity and systems of setting. In addition, this paper contributes to fulfilling the 11th SDGs, covering four pillars -social, economic, ecology, and cultural. The method used is qualitative-descriptive with content analysis to analyze data obtained from the literature study. The analysis is supported by empirical studies in Kete' Kesu village in North Toraja Regency. The chosen location is an ancient village with a fairly complete cultural landscape and good accessibility. The findings show that the systems of activity for Toraja people in Tongkonan and its cultural landscape include domestic, religius, ecology and socio-economic activities. The systems of setting for Tongkonan and its cultural landscape encompass Tongkonan itself, alang, grazing area, puya, rante, saroan, paddy field, forest/kombong, farm, lantang, middle yard, Tongkonan surrounding, penanian, territory/liliq, area diamben, area ma'dika, area renge direnge, bridge, villages, settlement, pasar, graveyard, parampa.
Pemetaan Kerentanan Bahaya Tsunami dengan Pemodelan Inundansi (Studi Kasus : Kabupaten Bantul)
Authors: Budiman Michael Jayanto , Sutoyo  , Syafiudin Moh Fifik 
Published: October 2024

Indonesia terletak di antara tiga pelat tektonik utama dunia yaitu Lempeng Indo-Australia, Lempeng Pasifik, dan Lempeng Eurasia yang saling berinteraksi. Dari interaksi lempeng ini, terdapat potensi gempa besar berdasarkan pemodelan gempa megathrust pada seismic gaps dengan data histori gempa serta tsunami sebelumnya. Akumulasi energi dari seismic gaps ini dapat mencapai titik kritis yang dapat menyebabkan gempa bumi berskala besar dan menimbulkan tsunami. Hasil pemodelan tsunami mecapai ketinggian maksimal 20 m dan 12 m sepanjang pesisir selatan Pulau Jawa. Tujuan penelitian pada kali ini adalah menganalisis bahaya tsunami untuk mendapatkan luas genangannya, tutupan lahan terdampak tsunami, dan jumlah penduduk yagn terdampak. Bahaya tsunami didapat dari pemodelan inundasi tsunami dengan skenario run up tsunami 10, 15, dan 20 meter. Pemodelan inundasi tsunami menggunakan bantuan tool model builder pada aplikasi ArcGIS dengan mengolah data spasial menggunakan persamaan yang dikembangkan Berryman. Data spasial yang digunakan dalam persamaan ini adalah data tutupan lahan, kelerengan, dan garis pantai. Hasil dari pengolahan ini berupa data luas genangan tsunami berbagai skenario ketinggian. Data tutupan lahan diolah dengan melakukan proses clipping dengan data hasil pemodelan inundasi tsunami. Untuk jumlah penududuk dilakukan dengan mengalikan luas genangan tsunami dengan kepadatan penduduk. Dari hasil pemodelan didapat bahwa luas genangan untuk run up tsunami 10 meter adalah 9,72 km2; run up tsunami 15 meter 15,69 km2; dan run up tsunami 20 meter 21,29 km2. Tutupan lahan berjenis padang rumput, pasir darat, perkebunan, tegalan / ladang, sawah terdampak limpasan tsunami yang luas. Terdapat total 8940 penduduk yang terdampak oleh limpasan tsunami saat ketinggian run up tsunami 10 meter, 15060 penduduk yang terdampak saat run up tsunami 15 meter, dan terdapat dan 23870 penduduk yang terdampak saat ketinggian run up tsunami 20 meter
Analisis Karakteristik Penumpang Bus Trans Banyumas Terhadap Karakteristik Perilaku Perjalanan Pada Koridor I Pasar Pon – Terminal Ajibarang
Authors: Fauziah Titania Nur , Juanita Juanita , Sari Cremona Ayu Novita 
Published: October 2024

Kota Banyumas memiliki BRT Trans-Banyumas sebagai salah satu transportasi massal yang diharapkan menjadi transportasi dengan pelayanan terbaik, nyaman, aman, dan cepat. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana karakteristik penumpang Bus Trans Banyumas mempengaruhi karakteristik perilaku perjalanan pada koridor 1 menggunakan metode analisis statistik deskriptif. Karakteristik sosio ekonomi dan demografi penumpang terlihat dari hasil pengolahan data 250 responden yang di survey didapati bahwa dari jenis kelamin perempuan lebih banyak dengan tingkat usia terbanyak di umur 35-50 tahun dengan pendidikan terakhir mayoritas SMA. Terkait maksud perjalanan responden didominasi oleh rekreasi/belanja, untuk profesi didominasi oleh lainnya. Dengan mayoritas pendapatan rata-rata perbulan sebesar 1 jt – 2 jt. Karakteristik perilaku perjalanan dari data yang diperoleh dan diolah untuk moda sebelum beralih menngunakan bus trans banyumas didominasi menggunakan bus/angkot. Kemudian untuk moda perjalanan hubung dan moda transportasi yang digunakan baik dari rumah menuju shelter dan dari shelter menuju ketempat tujuan didominasi oleh jalan kaki. Kemudian untuk jarak perjalanan hubung dari rumah menuju shelter dan dari shelter menuju ketempat tujuan adalah > 400 m. Dengan pemilihan rekan berjalan mayoritas sendiri dengan mayoritas alasan sehat. Tidak semua kondisi demografi sosial ekonomi mempengaruhi karakteristik perilaku perjalanan.
Enterprise aerchitecturte
Authors: hall mike 
Published: October 2024

cosmic civilization, 'tramnsparency where underlaying, 'civilization decadence, 'anthropic organology historic manuscripts 'governance of archeology compose decadence; 'creation anthropic; 'block-chain theology', from histioric organology; ' theological denomination of oriented creation 'anthropic life path graphics, on 'subjective; topic of creation lifeform, anthropic {human} inheritance.
ПРОБЛЕМИ І ПЕРСПЕКТИВИ РОЗВИТКУ РИНКУ ІНФОРМАЦІЙНИХ ТЕХНОЛОГІЙ В УКРАЇНІ
Authors: КУСТОВ Віталій , ТРЯЩЕНКО Віталій 
Published: October 2024

The article analyzes the current issues that are preventing the development of the information technology market in Ukraine. It has been established that the leaders of the Ukrainian IT industry have already achieved significant success and have several undeniable achievements. The lack of a well-established state policy is preventing Ukraine from competing effectively in the global IT market as a producer of goods. The analysis of countries' global digital competitiveness ratings revealed that the world market of information technologies is segmented based on types, programs, and subtypes. Due to several factors, the information technology market in Ukraine has been growing moderately.
Firstly, there is an increasing demand for advanced technologies and digitalization, along with positive trends in remote working, which is the usual mode for IT companies; secondly - the emergence of new information technologies and systems, products, IT services, and companies; thirdly, the development of the communications system, electronic payments, and e-commerce have also played a role in the market's expansion. Fourth, the increased digitalization in various sectors of the economy, including healthcare, government, finance, and education, is expected to drive the highest growth rates in the IT market; fifth, the growth of the IT market is also being fueled by the attraction of significant investments through progressive IT start-ups, sixth, the rapidly growing IT workforce. Lastly, there is an annual increase in the share of the Ukrainian IT market in the export of services.
The effectiveness of the information technology market in Ukraine's export of services is presented through the dynamics of indicators from 2018 to 2022. Ukrainian IT companies should focus on further developing their information products to improve the situation. The article analyzes Ukraine's top 10 IT companies, where service companies dominate.
It also summarizes the challenges that are hindering the development of the information technology market in Ukraine. Additionally, the article suggests directions that can help create a developed digital Ukrainian nation. Several measures are proposed to facilitate the rapid development of the information technology market in Ukraine. The first is to focus on building the world's first digital country, which involves ensuring secure and uninterrupted Internet access for all residents throughout the territory, this can be achieved by leveraging technologies like StarLink and other similar advancements. Secondly, there is a proposal to create a territory of innovation, which would involve technological integration and the introduction of new technologies. Thirdly, the development of high-tech and future-tech products is emphasized. Fourthly, the suggestion is to fully operate the virtual economy in parallel with the traditional one. Lastly, there is a proposal to attract major global services to Ukraine, such as global investment banks and Amazon services.
ӘБДІЛДА ТӘЖІБАЕВТЫҢ ЭПИСТОЛЯРЛЫҚ МҰРАСЫН ОҚЫТУДЫҢ ТИІМДІ ӘДІСТЕРІ
Authors: Уразова А.К. , Тұяқбаев Ғ.Ә. , Құдайбергенова К.Т. , Жолмаханова А.Б. 
Published: October 2024

Білім мен тәжірибені жеткізу тәсілдерінің бірі – эпистолография – ертеден дамып, қалыптасып келе жатқан хат жазу туралы ғылым. Хаттар арқылы біз адамдардың өмірлік тәжірибесі мен ойлары, тұжырымдары мен идеялары туралы біле аламыз. Қазақстанның көрнекті эпистологтарының бірі – жазушы, публицист, әдебиеттанушы, көптеген хаттар мен мақалалардың авторы Әбділда Тәжібаевтың эпистолярлық мұрасымен танысу зерттеудің маңыздылығын көрсетеді. Сонымен қатар, жазушының еңбектері зерттеу нысаны бола отырып, қазақ эпистолографиясын оқыту әдістемесінің үлгісі ретінде алғаш рет қарастырылады. Зерттеудің мақсаты – Әбділда Тәжібаевтың эпистолярлық мұрасын оқытудың тиімді әдіс-тәсілдерін зерттеп, оны оқытудың маңыздылығын тәжірибеде дәлелдеу. Зерттеу нәтижесінде Әбділда Тәжібаевтың эпистолярлық мұрасын қазақ әдебиетін оқытуда ақпарат көзі ретінде оқытудың тиімді әдістері мен эпистолярлық мәтіндерді талдау және түсіндірудің кезеңдері қарастырылды.
Зерттеудің жаңалығы – Әбділда Тәжібаевтың эпистолярлық мұрасы Қазақстанның мәдениеті мен тарихы туралы құнды ақпарат көзі ретінде қарастырылып, жоғары әдеби стиль үлгісі ретінде ұсынылды. Зерттеудің практикалық маңыздылығы – зерттеу нәтижелерін қазақ әдебиеті сабақтарында эпистолярлық шығармаларды оқыту әдістемесінде қолдану мүмкіндігі бар. Сондай-ақ, зерттеудің тұжырымдарын қазақ эпистолярлық мұрасын зерттеудің негізгі мәселелері мен перспективаларын жетілдіруде және бағалауда қолдануға болады.
Indeks Kepuasan Warga Binaan Pemasyarakatan Terhadap Pelayanan Produk Makanan
Authors: Jayanti Nur Ria Tri , Cahyawati Cahyawati , Prasetya Desman Agung 
Published: October 2024

Latar Belakang: Jumlah gangguan keamanan dan ketertiban di penjara atau tempat penahanan merupakan salah satu perhatian banyak orang karena menyebabkan ketidaknyamanan bagi masyarakat. Hal ini disebabkan oleh banyak faktor, salah satunya adalah kurangnya pemenuhan hak-hak narapidana (WBP) seperti makanan dan air. Kualitas makanan dan minuman juga menunjukkan tingkat kesehatan narapidana. Oleh karena itu, perlu dilakukan perhitungan indeks kepuasan layanan produk makanan di Lembaga Pemasyarakatan Kelas IIA Yogyakarta, yang bertujuan sebagai langkah pencegahan terjadinya kerusuhan dan bentuk jaminan kesehatan bagi WBP serta dapat diterapkan untuk memperbaiki kekurangan layanan.Metode: Menggunakan metode deskriptif dengan pendekatan kuantitatif. Populasi 147 orang dengan sampel 15 orang melalui sistem pengambilan simple random sampling menggunakan indeks pedoman kepuasan masyarakat (IKM). Metode analisis data menggunakan statistik deskriptif. Hasil: Data kepuasan mengenai variasi menu, cara penyajian, waktu penyajian, tempat dan peralatan makan serta petugas layanan dengan hasil nilai interval IKM sebesar 3,66 dengan nilai konversi IKM 91 yang menunjukkan bahwa indeks kepuasan WBP terhadap layanan produk makanan sangat baik. Dan tingkat layanan produk makanan yang baik dapat menunjukkan bahwa keterampilan kesehatan WBP juga baik. Kesimpulan: Nilai kualitas layanan produk makanan berada pada kinerja unit layanan yang sangat baik.