bluuebunny/crossref_metadata_2025_split huggingface dataset:
BIOMECHANICAL ANALYSIS OF DIFFERENT PROSTHETIC TECHNOLOGIES FOR TRANS-FEMORAL AMPUTEES DURING SLOPE DESCENT
Authors: Stech Nadine , McGrath Michael , Laszczak Piotr , Kercher Alan , Zahedi Saeed , Moser David 
Published: February 2019

INTRODUCTION
Lower limb amputees have different biomechanics to able-bodied people when walking on slopes1,2, often struggling to negotiate different gradients safely. Loss of proprioception and muscular control contributes to this issue, which is a particular problem for trans-femoral amputees, where both ankle and knee joints are absent. Studies have shown that prosthetic technologies can have benefits for slope negotiation. The aim of this study was to isolate the specific effects of different trans-femoral prosthetic technologies, by applying each additional mechanism incrementally.
Abstract PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32012/24431
How to cite: Stech N, McGrath M, Laszczak P, Kercher A, Zahedi S, Moser D. BIOMECHANICAL ANALYSIS OF DIFFERENT PROSTHETIC TECHNOLOGIES FOR TRANS-FEMORAL AMPUTEES DURING SLOPE DESCENT. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, POSTER PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32012
Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee.
http://www.aopanet.org/
CHANGES IN POSTURAL STEADINESS FOLLOWING TRANS-TIBIAL AMPUTATIONS
Authors: Henness Douglas , Medema Arianna , Steinhorst Kendra , Moauro Robert , Reuland Michael , Whelan Robert , Kester Shawna , Bateni Hamid 
Published: February 2019

INTRODUCTION
Increased risk of falling following amputation is well documented in literature.1 As the amputee population ages, accidental falls become a greater problem. Trans- tibial amputations are one of the most common levels of amputation. We hypothesized that postural steadiness is deteriorated following trans-tibial amputation as compared to age matched younger adults.
Abstract PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32014/24433
How to cite: Henness D, Medema A, Steinhorst K, Moauro R, Reuland M, Whelan R, Kester S, Bateni H. CHANGES IN POSTURAL STEADINESS FOLLOWING TRANS-TIBIAL AMPUTATIONS. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, POSTER PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32014
Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee.
http://www.aopanet.org/
INHIBITING PSEUDOMONAS AERUGINOSA GROWTH ASSOCIATED WITH PROSTHETIC LINERS
Authors: Jarrell John D , Garcia Dioscaris R , Born Christopher T 
Published: February 2019

INTRODUCTION
The conventional use of a prosthetic device by amputees involves contact of the residual limb tissue with the prosthetic socket using an intermediate elastomer liner. Roll-on gel liners are applied directly to the limb, and slide into the rigid hard socket; the gels are generally silicone or plastic. Regardless of the material, or the liner system used on a residual limb, problems occur because of direct skin and socket or liner contact.1 The skin tissue of the residual limb is subject to compressive, shear, and tensile forces through weight bearing against the interface wall. In addition the skin is subject to heat/sweat issues that may be seasonal and related to the insulation properties of the interface material. A common problem encountered by the prosthetic user is socket odor, or odor emanating from socket liners.2 Proper hygiene does not guarantee the reduction of strong socket or liner odor over time. In addition, skin problems among amputees include rashes, blistering, mold/fungal infections and other skin irritations. The socket/wall interface (regardless of material composition) is subject to local skin sloughing, sweat, and skin oils in a warm/moist dark environment over hours of use providing an ideal environment for fungal and bacterial growth.3 To address this problem, our team evaluated a titanium and silicone hybrid cleaning and coating technology containing a silver fatty acid complex against the odor producing, Gram-negative, facultative anaerobe, Pseudomonas aeruginosa.4
Abstract PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32016/24435
How to cite: Jarrell J.D, Garcia D.R, Born C.T. INHIBITING PSEUDOMONAS AERUGINOSA GROWTH ASSOCIATED WITH PROSTHETIC LINERS. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, POSTER PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32016
Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee.
http://www.aopanet.org/
AN IMMEDIATE FIT AND ADJUSTABLE TRANSTIBIAL PROSTHETIC SYSTEM; A PROSPECTIVE FEASIBILITY AND EFFICACY STUDY
Authors: Dillingham Timothy R , Kenia Jessica , Shofer Frances S , Marschalek Jim 
Published: February 2019

INTRODUCTION
Limb loss rates globally are rising and there is a large unmet need for an affordable and accessible prosthetic system for this growing US and International population. The purpose of this prospective cohort study was to assess the feasibility and utility of a novel immediate fit modular prosthetic system (IFIT Prosthetics, LLC™ prosthesis) for transtibial amputees.
Abstract PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32025/24442
How to cite: Dillingham T.R, Kenia J, Shofer F.S, Marschalek J. AN IMMEDIATE FIT AND ADJUSTABLE TRANSTIBIAL PROSTHETIC SYSTEM; A PROSPECTIVE FEASIBILITY AND EFFICACY STUDY. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, POSTER PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32025
Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee.
http://www.aopanet.org/
FACTORS ASSOCIATED WITH MOBILITY APPREHENSION IN AMPUTEES
Authors: Mathis Shannon L 
Published: February 2019

INTRODUCTION
Studies report that after lower-limb amputation, patients have high levels of pain in the form of chronic low back pain, residual limb pain, and phantom pain leading to restrictions in functional activity1. Patients with high levels of pain and disability may develop avoidance behaviors. Vlaeyen et al. presents the fear-avoidance model, which suggests that after an injury there are two pathways a patient will take based on their interpretation of acute pain 2. Pain that is perceived as non-threatening leads to the patient’s recovery and return to normal activities of daily life. Pain that is perceived as threatening, or pain catastrophizing, causes anxiety and induces mobility apprehension which leads to avoidance behaviors. Avoidance behaviors may then lead to greater pain, depression, and disability3 . Factors described in the literature that are related to mobility apprehension were measured in a sample of lower limb amputees. The purpose was to determine which of pain intensity, interference, and catastrophizing lead to increased mobility apprehension.
Abstract PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32040/24454
How to cite: Mathis S.L. FACTORS ASSOCIATED WITH MOBILITY APPREHENSION IN AMPUTEES. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, ORAL PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32040
Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee.
http://www.aopanet.org/
CASE STUDY: THERMOPLASTIC SCAPULOTHORACIC ORTHOSIS FOR TREATMENT OF WINGING SCAPULA
Authors: Brown Steven , Trexler Gary 
Published: February 2019

INTRODUCTION
Winging scapula is a rare condition that can be painful and debilitating to the upper extremity involved1. This condition can affect the functional ability of the upper extremity, resulting in loss of range of motion, decreased power, and pain.1 The purpose of this study was to introduce and determine the clinical applicability of a custom thermoplastic scapulothoracic orthosis to aid in management of winging scapula. The thermoplastic scapulothoracic orthosis offers total contact and provides anterior-posterior compressive forces to stabilize the winging scapula. This design provides a semi-rigid structure that is lightweight and allows user adjustability. The study highlights the potential applicability of the custom thermoplastic scapulothoracic orthosis in the categories of pain, active range of motion at the shoulder, and overall self-reported activities of daily living.
Abstract PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32043/24457
How to cite: Brown S, Trexler G. CASE STUDY: THERMOPLASTIC SCAPULOTHORACIC ORTHOSIS FOR TREATMENT OF WINGING SCAPULA. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, ORAL PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32043
Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee.
http://www.aopanet.org/
Healthcare Advocacy And Moral Distress In The Practice Of Nurses
Authors: Ramos Aline Marcelino , Barlem Edison Luiz Devos , Barlem Jamila Geri Tomaschewski , Rocha Laurelize Pereira , Silveira Rosemary Silva da , Pereira Liliane Alves 
Published: February 2019

Background: By focusing in prioritizing patients and their rights, occasional limitations may arise and prevent nurses from doing their work according to their social and professional commitment. This may culminate in Moral Distress, resulting from the incoherence between the nurses' actions and their personal convictions.
Research question: Is there any relationship between healthcare advocacy and moral distress in the practice of nurses working in hospitals?
Objective: Analyzing the relation between healthcare advocacy and moral distress in the practice of nurses working in hospitals.
Research design: Quantitative, analytical cross-sectional study. The data collection instruments comprise the Moral Distress Scale Revised – Brazilian version and the Protective Nursing Advocacy Scale – Brazilian version. Data analysis was carried out with elements of descriptive statistics, Pearson's correlation and linear regression analysis.
Participants and research context: The participants comprised 157 nurses working in two hospitals located in a city in southern Brazil. One of the institutions is a public university hospital and the other is a philanthropic institution.
Ethical considerations: All the international directives for research with human beings were observed.
Findings: The constructs barriers to the advocacy practice and negative implications to the advocacy practice were pointed out as predictors of moral distress.
Discussion: The situations approached in this study illustrate that certain organizational and cultural contexts have negative impacts on nurses, who are in constant contact with the necessity of promoting patient well being and increasing access to healthcare, especially under the perception of vulnerability in risk situations, or when the quality of the services provided decreases and patients are not given adequate assistance.
Conclusion: We hope that this study encourages the reflection about the relationship between patient advocacy and moral distress, and the search for resources that may contribute to the quality of the assistance provided by nurses.
CRISPR–Cas9D10A nickase‐assisted base editing in the solvent producer Clostridium beijerinckii
Authors: Li Qi , Seys François M. , Minton Nigel P. , Yang Junjie , Jiang Yu , Jiang Weihong , Yang Sheng 
Published: February 2019

AbstractClostridium beijerinckii is a potentially important industrial microorganism as it can synthesize valuable chemicals and fuels from various carbon sources. The establishment of convenient to use, effective gene tools with which the organism can be rapidly modified is essential if its full potential is to be realized. Here, we developed a genomic editing tool (pCBEclos) for use in
C. beijerinckii based on the fusion of cytidine deaminase (Apobec1), Cas9
D10A nickase and uracil DNA glycosylase inhibitor (UGI). Apobec1 and UGI are guided to the target site where they introduce specific base‐pair substitutions through the conversion of C·G to T·A. By appropriate choice of target sequence, these nucleotide changes are capable of creating missense mutation or null mutations in a gene. Through optimization of pCBEclos, the system derived, pCBEclos‐opt, has been used to rapidly generate four different mutants in
C. beijerinckii, in
pyrE,
xylR,
spo0A, and
araR. The efficiency of the system was such that they could sometimes be directly obtained following transformation, otherwise only requiring one single restreaking step. Whilst CRISPR–Cas9 nickase systems, such as pNICKclos2.0, have previously been reported in
C. beijerinckii, pCBEclos‐opt does not rely on homologous recombination, a process that is intrinsically inefficient in clostridia such as
C. beijerinckii. As a consequence, bulky editing templates do not need to be included in the knockout plasmids. This both reduces plasmid size and makes their construction simpler, for example, whereas the assembly of pNICKclos2.0 requires six primers for the assembly of a typical knockout plasmid, pCBEclos‐opt requires just two primers. The pCBEclos‐opt plasmid established here represents a powerful new tool for genome editing in
C. beijerinckii, which should be readily applicable to other clostridial species.
An integrated platform for mucin‐type O‐glycosylation network generation and visualization
Authors: Le Tung , O’Brien Conor , Gupta Udit , Sousa Guilherme , Daoutidis Prodromos , Hu Wei‐Shou 
Published: February 2019

AbstractMucin‐type O‐glycans have profound effects on the structure and stability of glycoproteins. O‐Glycans on the cell surface proteins also modulate the cell's interactions with the surrounding environments and other cells. The synthetic pathway of O‐glycans involves a large number of enzymes with diverse substrate specificity. The expression pattern of these enzymes is cell and tissue‐specific, thus making the pathway highly diverse. To facilitate pathway analysis in a cell and tissue‐specific fashion, we developed an integrated platform of RING (Rule Input Network Generator) and O‐GlycoVis. RING uses an English‐like reaction language to describe the substrate specificity of enzymes and additional constraints on the formation of the glycan products. Using this information, the RING generates a list of possible glycans, which is used as input into O‐Glycovis. O‐GlycoVis displays the glycan distribution in the pathway and potential reaction paths leading to each glycan. With the input glycan data, O‐GlycoVis also traces all possible reaction paths leading to each glycan and outputs pathway maps with the relative abundance levels of glycans overlaid. O‐Glycan profiles from two breast cancer cell lines, MCF7 and T47d, human umbilical vascular endothelium cells, Chinese Hamster Ovary cells were generated based on transcriptional data and compared with experimentally observed O‐glycans. This RING‐based program allows rules to be added or subtracted for network generation and visualization of networks of O‐glycosylation network of different tissues and species.
Impact of Oncology Drug Shortages on Chemotherapy Treatment
Authors: Alpert Abby , Jacobson Mireille 
Published: February 2019

Prescription drug shortages began to increase markedly in the mid‐2000s, including sterile injectable products such as chemotherapy drugs. Using Medicare claims linked to Surveillance Epidemiology and End Results (SEER), we examined outpatient chemotherapy use during shortage periods relative to the months before and after a shortage for newly diagnosed patients with breast, colorectal, leukemia, lung, lymphoma, ovarian, or pancreatic cancer (N = 182,470). For most drugs, we found little impact of shortages on either the fraction of patients receiving that drug or the quantity provided. In some cases, we found declines in utilization: 4% for doxorubicin and fluorouracil; 2.9% for oxaliplatin; and about 1% for cytarabine, dacarbazine, and leuprolide. Although shortages for a few drugs resulted in substantial reductions in use, in most cases, they resulted in little to no reduction. We discuss potential explanations for these counterintuitive findings, including potential limitations of current drug shortage reporting methods.
No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P‐glycoprotein
Authors: Zahner Catherine , Kruttschnitt Esther , Uricher Julia , Lissy Michael , Hirsch Martin , Nicolussi Simon , Krähenbühl Stephan , Drewe Jürgen 
Published: February 2019

Hypericum perforatum L. (St. John's wort) is used to treat mild‐to‐moderate depression. Its potential safety risks are pharmacokinetic drug interactions via cytochrome P450 (CYP) enzymes and P‐glycoprotein, presumably caused by hyperforin. In a phase I, open‐label, nonrandomized, single‐sequence study, the low‐hyperforin Hypericum extract Ze 117 was investigated using a drug cocktail in 20 healthy volunteers. No pharmacokinetic interactions of Ze 117 were observed for CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP3A4, and P‐glycoprotein. Area under the curve (AUC) and peak plasma concentration (Cmax) of the used probe drugs showed 90% confidence intervals (CIs) of the geometric mean ratios of the drugs taken together with Ze 117 vs. probe drug alone, well within the predefined bioequivalence range of 80–125%. Though Ze 117 did not induce dextromethorphan metabolism by CYP2D6, it weakly increased dextromethorphan AUC ratio (mean 147.99, 95% CI 126.32–173.39) but not the corresponding metabolic ratio. Ze 117 does not show clinically relevant pharmacokinetic interactions with important CYPs and P‐glycoprotein.
Color, chlorophyll a, and suspended solids effects on Secchi depth in lakes: implications for trophic state assessment
Authors: Brezonik Patrick L. , Bouchard R. William , Finlay Jacques C. , Griffin Claire G. , Olmanson Leif G. , Anderson Jesse P. , Arnold William A. , Hozalski Raymond 
Published: February 2019

AbstractSecchi depth (SD), a primary metric to assess trophic state, is controlled in many lakes by algal densities, measured as chlorophyll‐a (chl‐a) concentration. Two other optically related water quality variables also directly affect SD: non‐algal suspended solids (SSNA) and colored dissolved organic matter (CDOM, expressed as the absorption coefficient at 440 nm, a440). Using a database of ~1,460 samples from ~625 inland lake basins in Minnesota and two other Upper Midwest states, Wisconsin and Michigan, we analyzed relationships among these variables, with special focus on CDOM levels that influence SD values and the Minnesota SD standards used to assess eutrophication impairment of lakes. Log‐transformed chl‐a, total suspended solids (TSS), and SD were strongly correlated with each other; log(a440) had major effects on log(SD) but was only weakly correlated with log(chl‐a) and log(TSS). Multiple regression models for log(SD) and 1/SD based on the three driving variables (chl‐a, SSNA, and CDOM) explained ~80% of the variance in SD in the whole data set, but substantial differences in the form of the best‐fit relationships were found between major ecoregions. High chl‐a concentrations (> 50 μg/L) and TSS (> 20 mg/L) rarely occurred in lakes with high CDOM (a440 > ~4 m−1), and all lakes with a440 > 8 m−1 had SD ≤ 2.0 m despite low chl‐a values (<10 μg/L) in most lakes. Further statistical analyses revealed that CDOM has significant effects on SD at a440 values > ~ 4 m−1. Thus, SD is not an accurate trophic state metric in moderately to highly colored lakes, and Minnesota's 2‐m SD criterion should not be the sole metric to assess eutrophication impairment in warm/cool‐water lakes of the Northern Lakes and Forest ecoregion. More generally, trophic state assessments using SD in regions with large landscape sources of CDOM need to account for effects of CDOM on SD.
Detection of the major bacterial pathogens among children suffering from empyema in Ahvaz city, Iran
Authors: Amin Mansour , Yousef pour Samaneh , Navidifar Tahereh 
Published: February 2019

IntroductionEmpyema is one of the important causes of pediatric hospital admissions.AimIn this study, we had investigated the frequency rates of S aureus, S pneumoniae, H influenzae, and P aeruginosa using PCR and bacterial culture among children suffering from empyema in Ahvaz city, Iran.MethodsThis was a descriptive study conducted on the patients hospitalized in ICUs of two teaching Hospitals of Ahvaz, Iran, between March and September 2018 on 105 pleural fluid (PF) samples of the children less than 16 years of age with the diagnosis of empyema thoracis. These specimens were inoculated on the bacterial culture media and identified using biochemical characteristics. Then, the existence of the four pathogens mentioned above was evaluated using PCR method.ResultIn this study, these bacteria agents were identified in 81 (77.14%) and 30 (28.57%) cases using the PCR assay and bacterial culture, respectively. Moreover, the PCR assay identified the infectious agents in 51 (68%) of PFs where the culture method failed. S pneumoniae (63 cases) was recognized as the most common pathogen, followed by P aeruginosa(19 cases), S aureus(15 cases), and H influenzae (9 cases) using the bacterial culture and PCR. Co‐infections were detected in 21 samples (20%) using PCR and one sample using the bacterial culture (P aeruginosa and S pneumoniae).ConclusionIn this study, we found the higher frequencies of these microorganisms using PCR than culture. In addition, we showed that PCR was a sensitive and accurate method that unaffected by antibiotic therapy and could detect well co‐infections.
Compared to Dematerialized Money, Cash Increases Impatience in Intertemporal Choice
Authors: Duclos Rod , Khamitov Mansur 
Published: February 2019

When it comes to trading time for money (or vice versa), people tend to be impatient and myopic. Often dramatically so. For illustration, half of people would rather collect $15 now than $30 in 3 months. This willingness to forego 50% of the reward to skip a 3‐month wait corresponds to an annual discount rate of 277%. This article investigates how money's physical form biases intertemporal choice. We ask, what happens to (im)patience (i.e., discount rates) when time is traded against cash rather than against an equivalent sum of dematerialized money? We find that intertemporal decisions pitting time against cash (rather than against dematerialized money) increase impatience. The underlying mechanism relates to the pain of parting from money. Letting go of cash (dematerialized money) we can have now is psychologically more (less) painful, which in turn reduces (increases) our willingness to wait for larger‐later payoffs. Importantly, heightening prevention focus (i.e., concerns for safety and security) moderates this bias. The article concludes by discussing the implications of the research, particularly for the psychology of saving behavior.