bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective study of the efficacy of oral potassium supplementation in cats with kidney disease
Authors: Sieberg Liberty G , Quimby Jessica M 
Published: July 2019

Objectives The aim of this study was to assess the effect of three oral potassium supplements (potassium gluconate tablets [PGT], potassium gluconate granules [PGG] and potassium citrate granules [PCG]) on hypokalemia and serum bicarbonate in cats with chronic kidney disease (CKD). Methods Medical records (2006–2016) were retrospectively searched for cats that had been prescribed an oral potassium supplement for management of their CKD-associated hypokalemia. For inclusion, laboratory work had to be available at the time of hypokalemia diagnosis, and at recheck within 1–6 weeks. Treatment response was defined in three ways: any increase in potassium, an increase in potassium to within the normal reference interval, and an increase to >4 mEq/l. Results Thirty-seven cats met inclusion criteria (16 PGT, 11 PGG, 10 PCG). Dosing ranged from 0.21 to 1.6 mEq/kg/day for PGT, from 0.25 to 1.48 mEq/kg/day for PGG and from 0.04 to 1.34 mEq/kg/day for PCG. After supplementation, 36/37 cats had an increase in potassium, 34/37 increased to within the reference interval and 24/37 had an increase in potassium to >4 mEq/l. There was a statistically significant difference in serum potassium post-supplementation for all three treatments: PGT ( P = 0.0001), PGG ( P = 0.001) and PCG ( P = 0.002). There was a positive correlation between PGT dose and change in potassium concentration ( P = 0.04), but there was no significant correlation for PGG or PCG. In cats that had data available, serum bicarbonate increased >2 mEq/l in 1/6 PGT, 1/6 PGG and 3/4 PCG cats. Conclusions and relevance All three potassium supplements were effective in treating hypokalemia secondary to CKD in the majority of cats despite variable dosing. Data were limited to assess the alkalinizing effect and prospective studies are needed.
Decision making in the management of malunion and nonunion of intertrochanteric fractures of the hip
Authors: Bhowmick Kaushik , Matthai Thomas , Boopalan Perumal Ramaswamy JVC , Jepegnanam Thilak S 
Published: July 2019

Aim: Intertrochanteric fractures account for almost 50% of hip fractures.Nonunion and malunion of these fractures are relatively uncommon. This study reviews the outcome of 31 cases of intertrochanteric fracture failures. An algorithm for the management of these injuries is also proposed. Methods: 19 patients with intertrochanteric malunion and 12 patients with non-union were included in this study. Treatment of these injuries was initiated according to the algorithm proposed in this study. Treatment outcomes were evaluated by assessing union, pre and postoperative shortening and HSA (head-shaft angle). Functional outcomes were assessed by the Parker mobility scale and presence or absence of pain. Results: All the patients with intertrochanteric malunion with follow-up had united. The postoperative shortening in all patients were ⩽2.5 cms. Patients having intertrochanteric nonunion with follow-up, who underwent internal fixation had united with an acceptable Parker mobility scale score, except in 1 patient who sustained an ipsilateral distal femur fracture. The average HSA correction obtained was 21° (range 3–60°). Conclusion: The algorithm proposed in this study helps streamline the treatment according to each case scenario.It helps in planning and managing patients with intertrochanteric fracture failures.
The Effects of Intuitive Movement Reembodiment on the Quality of Life of Older Adults With Dementia: A Pilot Study
Authors: Choo Ting , Barak Yoram , East Ali 
Published: July 2019

Background: The creative use of reminiscent music and natural movements were reported to have positive effects on the well-being of older adults with cognitive impairment. Objectives: To explore the effects of the intuitive movement reembodiment (IMR) program on the quality of life (QoL) of older adults with dementia. Methods: Data collected from 22 participants were analyzed: group 1 (mild dementia), group 2 (moderate dementia), group 3 (advanced dementia). All study groups participated in 10 weekly sessions. Self-reported QoL ratings were gathered through using the World Health Organisation (WHO)-5 questionnaire, alongside qualitative evidence recorded through onsite observation. Results: Statistically significant improvement in QoL was demonstrated after session 6. The qualitative analysis showed that the IMR sessions provided a sense of humor, imagination, and intuition that motivated the participants to dance and interact with joy. Conclusion: These preliminary positive findings need to be replicated in a larger randomized controlled trial.
Evaluation of a Mental and Behavioral Health Patient Room Mockup at a VA Facility
Authors: Sachs Naomi A. , Shepley Mardelle M. , Peditto Kati , Hankinson Mary Therese , Smith Kathryn , Giebink Brian , Thompson Tammy 
Published: July 2019

Objective: The primary goal of this research was to evaluate a physical full-scale, high-fidelity mockup of a mental and behavioral health (MBH) inpatient room and bathroom. Background: There is minimal research on design for MBH and no published research using mockups to evaluate a MBH design proposal. To address this gap, an interdisciplinary team developed an ideal Patient-Centered MBH Patient Room, which was built as a mockup at a Veterans Administration (VA) facility and evaluated by patients and staff in situ. Method: The mock-up was evaluated using a structured mixed methods process that incorporates feedback using Feedback Forms and facilitated Listening Sessions. Our two primary hypotheses were that the design, as represented by the mock-up, would be positively evaluated and that there would be a difference between staff and patient perceptions, with patients rating the design higher than staff. Results: Quantitative analysis confirmed our hypotheses, revealing an overall positive response, with a difference between patients and staff. Contrary to hypothesis, staff consistently rated the design higher than patients. Qualitative analysis found mixed reception of the design and three primary themes: safety, homeyness/deinstitutionalization, and positive distraction/nature. Conclusions: Physical mock-ups may be an effective tool for evaluation of a proposed design; however, staff perceptions of the environment may differ from those of patients. One drawback of using a physical high-fidelity mock-up is the expectation that the mock-up perfectly represents the proposed design. With this project, even small unfinished details were distracting to the participants and may have negatively affected the evaluation.
Concomitant old complex fracture–dislocation of the first metatarsophalangeal, Lisfranc, and naviculocuneiform joints
Authors: Vosoughi Amir Reza , Akbarzadeh Armin 
Published: July 2019

Old simultaneous complex fracture–dislocation of the first metatarsophalangeal (MTP), Lisfranc, and naviculocuneiform joints as an overwhelming injury has not been reported in the literature yet. In a 29-year-old man, 6 months following the trauma, the medial column of foot was reconstructed using iliac tricortical bone graft from navicular to the first metatarsal. Arthrodesis of the second and third tarsometatarsal joints and resection arthroplasty of the first MTP joint were done. His clinical and radiographic evaluation after 18 months revealed an acceptable function with returning to pre-injury job but with some limitations in recreational activities. Level of evidence: level 4
The EUROLIGHT cluster headache project: Description of methods and the study population – An Internet-based cross-sectional study of people with cluster headache
Authors: Andrée Colette , Gantenbein Andreas R , Sandor Peter S , Schoenen Jean , Pohl Heiko 
Published: July 2019

Objective: To present the methodology and to describe the sample of a large, Internet-based survey on the burden of cluster headache (CH). Methods: Participants filled out a questionnaire online. Inclusion criteria were a reported diagnosis of CH and a residency in a European country; exclusion criteria were refusal to give informed consent and to complete the questionnaire. Results: A total of 1514 participants completed the questionnaire. Of these, 66.2% were male and 31.2% reported suffering from chronic CH. The diagnosis was validated based upon the responses in 92.9% of the participants. Other diagnoses seemed more likely in 0.8%. Among the participants with self-reported chronic CH, the International Classification of Headache Disorders-3 beta criteria for chronicity were fulfilled by 90.8%. Conclusions: In this article, we discuss the applied methodology as well as the properties of the sample. The overall accuracy of the self-reported diagnoses was very good as judged by our questionnaire; women and chronic CH were slightly over-represented. We will present the results of more thorough analyses in future articles and believe that these data will provide deeper insights into the burden of CH and will help to give a voice to those who endure this painful disease.
Hitachiite, Pb5Bi2Te2S6, a new mineral from the Hitachi mine, Ibaraki Prefecture, Japan
Authors: Kuribayashi Takahiro , Nagase Toshiro , Nozaki Tatsuo , Ishibashi Junichiro , Shimada Kazuhiko , Shimizu Masaaki , Momma Koichi 
Published: July 2019

AbstractHitachiite, Pb5Bi2Te2S6, is a new mineral discovered in the Hitachi mine, located in the Ibaraki Prefecture of Japan. The mean of 21 electron microprobe analyses gave: Pb 52.01, Bi 23.06, Fe 0.69, Sb 0.17, Te 13.74, S 9.71, Se 0.54, total 100.04 wt.%. The empirical chemical formula based on 15 apfu is (Pb4.75Fe0.23)Σ4.98(Bi2.09Sb0.03)Σ2.12Te2.04(S5.73Se0.13)Σ5.86, ideally Pb5Bi2Te2S6. Synchrotron single-crystal X-ray diffraction experiments indicated that hitachiite has trigonal symmetry, space groupP${\bar 3}$m1, witha= 4.2200(13) Å,c= 27.02(4) Å andZ= 1. The four strongest diffraction peaks shown in the powder X-ray pattern [d, Å (I)(hkl)] are: 3.541(35)(012), 3.391(59)(013), 3.039(100)(015) and 2.114(56)(110). The calculated density (Dcalc) for the empirical chemical formula is 7.54 g/cm3.The crystal structure of hitachiite has been refined using synchrotron single-crystal X-ray diffraction data, toR= 7.38% and is based onABC-type stacking of 15 layers (five Pb, two Bi, two Te, and six S layers) along the [001] direction, and with each layer ideally containing only one kind of atom. The stacking sequence is described as Te–Bi–S–Pb–S–Pb–S–Pb–S–Pb–S–Pb–S–Bi–Te. The discovery of hitachiite implies that the minerals of the Bi2Te2S–PbS join might form a homologous series of Bi2Te2S·nPbS.
α4β1 integrin associates with VEGFR2 in CLL cells and contributes to VEGF binding and intracellular signaling
Authors: Gutiérrez-González Alejandra , Aguilera-Montilla Noemí , Ugarte-Berzal Estefanía , Bailón Elvira , Cerro-Pardo Isabel , Sánchez-Maroto Clara , García-Campillo Lara , García-Marco José A. , García-Pardo Angeles 
Published: July 2019

Key Pointsα4β1 integrin and VEGFR2 function as a receptor complex for VEGF in CLL cells. Contribution to VEGF functions in CLL is a novel pathological role for α4β1 integrin in this malignancy.
Nano calcium carbonate versus nano calcium hydroxide in alcohols as a deacidification medium for lignocellulosic paper
Authors: Malešič Jasna , Kadivec Mariša , Kunaver Matjaž , Skalar Tina , Cigić Irena Kralj 
Published: July 2019

Abstract
Deacidification is an established conservation treatment for the prolongation of the acidic paper stability. Several different deacidification systems are in use today, such as the dispersions of alkaline nanoparticles in organic solvents. The aim of the study was to compare the effects of different calcium nanoparticle dispersions in alcohols on lignocellulosic paper. Commercially available nano calcium hydroxide dispersions for paper deacidification, and laboratory prepared nano calcium carbonate dispersions in ethanol and 2-propanol were investigated and compared as to their effectiveness in increasing the stability of paper. The FE-SEM analyses were used to determine the size of Ca(OH)2 and CaCO3 particles in the dispersions. The SEM–EDS analyses were performed both on the paper surface and its cross-section in order to ascertain the distribution of calcium ions following the deacidification treatment. An evaluation of the changes of color, molecular weight, pH and alkaline reserve on different lignocellulosic papers was performed. In comparison to untreated samples, our results indicate all the investigated deacidification treatments decrease the degradation rate constant of cellulose, as determined by accelerated degradation. However, the treatments involving nano calcium hydroxides in both alcohols noticeably affect the color of the treated lignocellulosic papers. According to the obtained results, nano calcium carbonate is therefore the more suitable deacidification agent for the lignin containing papers.
Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives
Authors: Wang Jing‐Bo , Huang Xue , Li Fu‐Rong 
Published: July 2019

AbstractLung cancer is the leading cause of cancer mortality worldwide. Dendritic cells (DCs) are the key factors providing protective immunity against lung tumors and clinical trials have proven that DC function is reduced in lung cancer patients. It is evident that the immunoregulatory network may play a key role in the failure of the immune response to terminate tumors. Lung tumors likely employ numerous strategies to suppress DC‐based anti‐tumor immunity. Here, we summarize the recent advances in our understanding on lung tumor‐induced immunosuppression in DCs, which affects the initiation and development of T‐cell responses. We also describe which existing measures to restore DC function may be useful for clinical treatment of lung tumors. Furthering our knowledge of how lung cancer cells alter DC function to generate a tumor‐supportive environment will be essential in order to guide the design of new immunotherapy strategies for clinical use.
Can Administrative Data Improve the Performance of Cancer Clinical Trial Economic Analyses?
Authors: Hanna Timothy P. , Nguyen Paul , Pater Joseph , O’Callaghan Christopher J. , Mittmann Nicole , Earle Craig C. , Tu Dongsheng , Jonker Derek , Hay Annette E. 
Published: July 2019

PURPOSE: Trial economic analyses, such as cost-effectiveness analysis, often rely on trial-collected data, which are burdensome and expensive to collect and may be incomplete. In contrast, administrative databases systematically collect health system encounters. We investigated whether administrative data could improve the performance of cancer trial economic analysis. METHODS: Health administrative data were probabilistically linked to Ontario patient data from the Canadian Cancer Trials Group CO.17 trial (n = 572), which evaluated cetuximab plus best supportive care (75 linked Ontario patients) versus best supportive care alone (73 patients) in previously treated metastatic colorectal cancer. Trial-collected resource utilization data and vital status were compared with administrative data. Cost effectiveness in 2007 Canadian dollars was determined with bootstrap incremental cost-effectiveness ratio (ICER) CIs. RESULTS: Up to trial date of last contact, administrative data vital status was concordant in more than 96%. Twenty-nine subsequent deaths occurred. Up to trial last contact, there were 50 net additional hospitalizations in administrative data and 33 net additional emergency department visits. Total costs were $3,023,034 for the cetuximab group and $1,191,118 for the control group up to trial last contact. The ICER was $211,128 per life-year gained (90% CI, $101,396 to $694,950) up to trial last contact and $164,378 (90% CI, −$138,260 to $644,555) up to administrative data last contact. ICER estimates were similar to the analysis using trial-collected data. CONCLUSION: Administrative data were more complete than trial data for hospital encounters, a key cost driver in economic analysis. There was a longer follow-up. This demonstrates the potential of administrative data to relieve the burden of collecting key data in cancer trials, which represents a considerable effort and expense.
Factors Associated With Clinical Deterioration Among Patients Hospitalized on the Wards at a Tertiary Cancer Hospital
Authors: Lyons Patrick G. , Klaus Jeff , McEvoy Colleen A. , Westervelt Peter , Gage Brian F. , Kollef Marin H. 
Published: July 2019

PURPOSE: Patients hospitalized outside the intensive care unit (ICU) frequently experience clinical deterioration. Little has been done to describe the landscape of clinical deterioration among inpatients with cancer. We aimed to describe the frequency of clinical deterioration among patients with cancer hospitalized on the wards at a major academic hospital and to identify independent risk factors for clinical deterioration among these patients. METHODS: This was a retrospective cohort study at a 1,300-bed urban academic hospital with a 138-bed inpatient cancer center. We included consecutive admissions to the oncology wards between January 1, 2014, and June 30, 2017. We defined clinical deterioration as the composite of ward death and transfer to the ICU. RESULTS: We evaluated 21,219 admissions from 9,058 patients. The composite outcome occurred during 1,945 admissions (9.2%): 1,365 (6.4%) had at least one ICU transfer, and 580 (2.7%) involved ward death. Logistic regression identified several independent risk factors for clinical deterioration, including the following: age (odds ratio [OR], 1.33 per decade; 95% CI, 1.07 to 1.67), male sex (OR, 1.15; 95% CI, 1.05 to 1.33), comorbidities, illness severity (OR, 1.11; 95% CI, 1.10 to 1.13), emergency admission (OR, 1.45; 95% CI, 1.26 to 1.67), hospitalization on particular wards (OR, 1.525; 95% CI, 1.326 to 1.67), bacteremia (OR, 1.24; 95% CI, 1.01 to 1.52), fungemia (OR, 3.76; 95% CI, 1.90 to 7.41), tumor lysis syndrome (OR, 3.01; 95% CI, 2.41 to 3.76), and receipt of antimicrobials (OR, 2.04; 95% CI, 1.72 to 2.42) and transfusions (OR, 1.65; 95% CI, 1.42 to 1.92). CONCLUSION: Clinical deterioration was common; it occurred in more than 9% of admissions. Factors independently associated with deterioration included comorbidities, admission source, infections, and blood product transfusion.
The −839(A/C) Polymorphism in the ECE1 Isoform b Promoter Associates With Osteoporosis and Fractures
Authors: Hansen Karen E , Johnson Michael G , Carter Tonia C , Mayer John , Keuler Nicholas S , Blank Robert D 
Published: July 2019

Abstract

Context
We previously found that variation in a quantitative trait locus, including the gene-encoding endothelin-converting enzyme 1 (Ece1), accounted for 40% of the variance in bone biomechanics and bone mineral density (BMD) in an intercross of recombinant congenic mouse strains.

Objective
We hypothesized that single nucleotide polymorphisms (SNPs) within the human ECE1 isoform b promoters, at ECE1 b −338(G/T) and ECE1 b −839(A/C), would associate with osteoporosis in postmenopausal women.

Design
We genotyped DNA for the ECE1 −338(G/T) and −839(A/C) SNPs.

Setting
A community medical center.

Participants
Postmenopausal women (3564) with ≥1 dual-energy X-ray absorptiometry scan ≥60 years of age.

Main Outcome Measures
BMD, osteoporosis, and clinical fractures.

Results
In multivariate models controlling for age, weight, healthcare duration, and tobacco, the CC genotype reduced the odds of lifetime fracture (OR 0.33, 95% CI 0.12, 0.87) and fracture ≥50 years of age (OR 0.31, 95% CI 0.11, 0.87), whereas the AC genotype increased odds of osteoporosis (OR 1.34, 95% CI 1.02 1.78) relative to the AA genotype. However, when controlling the false-discovery rate, findings were no longer significant. We found no consistent relationship between the ECE1 b −338(G/T) and study outcomes.

Conclusions
The CC genotype was associated with fewer fractures, whereas the AC genotype was associated with osteoporosis. Our small sample size and few minorities are study limitations. Findings should be tested in another cohort to confirm a link between the ECE1 −839(A/C) SNPs and osteoporosis.
Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring
Authors: Renner Simone , Martins Ana Sofia , Streckel Elisabeth , Braun-Reichhart Christina , Backman Mattias , Prehn Cornelia , Klymiuk Nikolai , Bähr Andrea , Blutke Andreas , Landbrecht-Schessl Christina , Wünsch Annegret , Kessler Barbara , Kurome Mayuko , Hinrichs Arne , Koopmans Sietse-Jan , Krebs Stefan , Kemter Elisabeth , Rathkolb Birgit , Nagashima Hiroshi , Blum Helmut , Ritzmann Mathias , Wanke Rüdiger , Aigner Bernhard , Adamski Jerzy , Hrabě de Angelis Martin , Wolf Eckhard 
Published: July 2019

ABSTRACT
Alongside the obesity epidemic, the prevalence of maternal diabetes is rising worldwide, and adverse effects on fetal development and metabolic disturbances in the offspring's later life have been described. To clarify whether metabolic programming effects are due to mild maternal hyperglycemia without confounding obesity, we investigated wild-type offspring of INSC93S transgenic pigs, which are a novel genetically modified large-animal model expressing mutant insulin (INS) C93S in pancreatic β-cells. This mutation results in impaired glucose tolerance, mild fasting hyperglycemia and insulin resistance during late pregnancy. Compared with offspring from wild-type sows, piglets from hyperglycemic mothers showed impaired glucose tolerance and insulin resistance (homeostatic model assessment of insulin resistance: +3-fold in males; +4.4-fold in females) prior to colostrum uptake. Targeted metabolomics in the fasting and insulin-stimulated state revealed distinct alterations in the plasma metabolic profile of piglets from hyperglycemic mothers. They showed increased levels of acylcarnitines, gluconeogenic precursors such as alanine, phospholipids (in particular lyso-phosphatidylcholines) and α-aminoadipic acid, a potential biomarker for type 2 diabetes. These observations indicate that mild gestational hyperglycemia can cause impaired glucose tolerance, insulin resistance and associated metabolic alterations in neonatal offspring of a large-animal model born at a developmental maturation status comparable to human babies.