bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial
Authors: Yong Wei Peng , Rha Sun Young , Tan Iain Bee-Huat , Choo Su-Pin , Syn Nicholas L. , Koh Vivien , Tan Shi-Hui , Asuncion Bernadette Reyna , Sundar Raghav , So Jimmy Bok-Yan , Shabbir Asim , Tan Chee-Seng , Kim Hyo-Song , Jung Minkyu , Chung Hyun Cheol , Ng Matthew C.H. , Tai David Wai-Meng , Lee Ming-Hui , Wu Jeanie , Yeoh Khay Guan , Tan Patrick 
Published: July 2018

Abstract
Purpose: The oxaliplatin plus S-1 and cisplatin plus S-1 regimens are interchangeably used in the management of advanced gastric cancer. The previously reported G-intestinal (G1) and G-diffuse (G2) intrinsic gene expression signatures showed promise for stratifying patients according to their tumor sensitivity to oxaliplatin or cisplatin.
Experimental Design: The proof-of-concept, multicenter, open-label phase II “3G” trial was done to prospectively evaluate the feasibility and efficacy of using genomic classifiers to tailor treatment in gastric cancer. Patients’ tumors were classified as “G1” or “G2” using a nearest-prediction template method, or “G3” (unclear assignment) when FDR ≥ 0.05. The first 30 patients in the “G1” cohort were assigned oxaliplatin plus S-1 (SOX) chemotherapy; thereafter, subsequently recruited “G1” patients were treated with cisplatin plus S-1 (SP) chemotherapy. “G2” patients and “G3” patients were treated with SP and SOX chemotherapy, respectively.
Results: A total of 48, 21, and 12 patients, respectively, were given “G1,” “G2,” and “G3” genomic assignments. Median turnaround time was 7 days (IQR, 5–9). Response rates were 44.8%, 8.3%, 26.7%, and 55.6% for the “G1-SOX,” “G1-SP,” “G2,” “G3” cohorts, respectively; and was higher in G1 patients treated with SOX compared with SP (P = 0.033). Exploratory analyses using the genomic classifier of Lei and colleagues validated the utility of the metabolic signature as a biomarker for predicting benefit from chemotherapy (log-rank P = 0.004 for PFS), whereas the Asian Cancer Research Group classifier did not demonstrate any predictive value.
Conclusions: This bench-to-bedside effort establishes a reasonable turnaround time for gene expression profiling and possible utility of genomic classifiers in gastric cancer treatment stratification. Clin Cancer Res; 24(21); 5272–81. ©2018 AACR.
Local Enhancement of Extreme Precipitation during Atmospheric Rivers as Simulated in a Regional Climate Model
Authors: Lorente-Plazas Raquel , Mitchell Todd P. , Mauger Guillaume , Salathé Eric P. 
Published: July 2018

Abstract
This paper examines the synoptic conditions that yield extreme precipitation in two regions with different orographic features, the Olympic Mountains and Puget Sound. To capture orographic extreme precipitation, a dynamical downscaling is performed, driven by the NCEP–NCAR reanalysis and evaluated for cool-season months from 1970 to 2010. Clustering techniques are applied to the regional climate simulation, which reveals the Olympic Mountains and Puget Sound as regions with distinct temporal variability in precipitation. Results show that approximately one-third of the extreme precipitation events in each region occur without a similarly extreme event in the other, in spite of the fact that the two areas are very closely located and one is downstream of the other. Composites of synoptic conditions for extreme precipitation events show differences in integrated vapor transport (IVT) due to its dynamical component (winds at 850 hPa) and its thermodynamical component [integrated water vapor (IWV)]. For Puget Sound events, IVT is lower compared to Olympic Mountain events because of lower wind speeds. Olympic Mountain events have lower IVT compared to events with extreme precipitation in both regions, but in this case, the difference is due to lower IWV and more southerly winds. These differences in the large-scale conditions promote differences in the mesoscale mechanisms that enhance precipitation in each location. For Puget Sound events, static stability is higher, and there is a weak rain shadow. For Olympic Mountain events, static stability is lower, and a strong rain shadow is present. During extreme events in both regions, orographic modulation is minimized and large-scale effects dominate.
Convective Boundary Layer Depth Estimation from S-Band Dual-Polarization Radar
Authors: Banghoff John R. , Stensrud David J. , Kumjian Matthew R. 
Published: July 2018

AbstractThis study investigates Bragg scatter signatures in dual-polarization radar observations, which are defined by low differential reflectivity values, as a proxy for convective boundary layer (CBL) depth. Using data from the WSR-88D in Twin Lakes, Oklahoma (KTLX), local minima in quasi-vertical profiles of are found to provide a reasonable estimate of CBL depth when compared with depth estimates from upper-air soundings from Norman, Oklahoma (KOUN), during 2014. The 243 Bragg scatter and upper-air sounding CBL depth estimates have a correlation of 0.90 and an RMSE of 254 m. Using Bragg scatter as a proxy for CBL depth was expanded to other seasons and locations—performing well in Wilmington, Ohio; Fairbanks, Alaska; Tucson, Arizona; Minneapolis, Minnesota; Albany, New York; Portland, Oregon; and Tampa, Florida—showing its potential usefulness in monitoring CBL depth throughout the year in a variety of geographic locations and meteorological conditions.
FELASA accreditation of education and training courses in laboratory animal science according to the Directive 2010/63/EU
Authors: Gyger Marcel , Berdoy Manuel , Dontas Ismene , Kolf-Clauw Martine , Santos Ana Isabel , Sjöquist Mats 
Published: July 2018

This document describes how the Federation of European Laboratory Animal Science Associations (FELASA) accreditation addresses both the Directive 2010/63/EU and the related European Commission guidance document. The four EU Functions and beyond: FELASA accredits courses that fulfil the requirements of Functions A, B, C and D as defined by EU Directive, Article 23, as well as for designated veterinarians and specialists in laboratory animal science. Modularity and mobility: Cohesive courses for Functions and for very specific topics are accredited, but flexibility and mobility are possible: a researcher can start his/her training with one FELASA accredited course and complete other modules with another. A course organizer will deliver a FELASA certificate relating to the successfully completed modules. Accreditation process: The process consists of two major steps: (1) a review of full course documentation provided by the applicant will lead, if successful, to FELASA accreditation. The course is posted on the FELASA website as ‘FELASA accredited’ and the course provider can deliver FELASA certificates upon successful completion of the course; (2) successful accreditation is followed by an on-site course audit. In the case of a negative outcome of the audit, FELASA accreditation is withdrawn, the course is deleted from the list of FELASA accredited courses and FELASA certificates cannot be issued. To ensure that quality is maintained, continuation of accreditation requires regular revalidation.
Accuracy of tumor size measurement: comparison of B-mode ultrasound, strain elastography, and 2D and 3D shear wave elastography with histopathological lesion size
Authors: Farrokh André , Maass Nicolai , Treu Linn , Heilmann Thorsten , Schäfer Fritz KW 
Published: July 2018

Background Predicting the exact extent of a breast tumor is of great importance for oncologic treatment strategies. Different types of elastography can be used as new tools for measuring lesion size. Purpose To provide evidence regarding the accuracy of tumor size measurement of strain elastography (SE), two-dimensional (2D) and three-dimensional (3D) shear wave elastography (SWE), and conventional B-image ultrasound. Material and Methods In this prospective study, the diameter of 105 malignant breast lesions was measured by SE, 2D and 3D SWE, and B-mode ultrasound. The histopathological lesion size was compared to all imaging-based measuring methods. Results The mean lesion size of all breast carcinomas was 1.54 cm. B-mode ultrasound underestimates breast cancer size in 65.7 % of all cases in this study ( P < 0.0001). Mean lesion size was more accurately determined by SE, 2D and 3D SWE compared to B-mode ultrasound. Absolute differences between measured and actual lesion are smaller for B-mode ultrasound (0.26 cm) than for SE (0.41 cm) and 2D and 3D SWE (0.41 cm and 0.44 cm, respectively). Conclusion B-mode ultrasound allows more accurate lesion size measurement than SE and 2D or 3D SWE but has a significantly higher risk of underestimating tumor size which could lead to incomplete margins during surgery. 3D SWE was not superior to 2D SWE or SE but by trend more precise in predicting the size of invasive lobular carcinoma.
Assessing body sensations in children: Intra-rater reliability of assessment and effects of age
Authors: Taylor Susan , McLean Belinda , Falkmer Torbjorn , Carey Leeanne M , Girdler Sonya , Elliott Catherine , Blair Eve 
Published: July 2018

Introduction This article examines the effect of age and gender on somatosensory capacity for children and adolescents, and provides preliminary normative data and reliability for the SenScreen© Kids, a new standardised measure of touch, wrist position sense and haptic object recognition. Method A cross-sectional study of 88 typically developing children aged 6–15 years (mean 10.3 years; SD 2.6 years) was used to determine the developmental effects of age and gender on somatosensory capacity. Intra-rater reliability was assessed in 22 of the 88 participants at two time points (mean 8.8 years; SD 2.6 years). Results Statistically significant differences were observed between age groups for tactile discrimination, wrist position sense and haptic object recognition, but not for touch registration for which all except one participant achieved a maximum score. There was no effect of gender. Three of four SenScreen Kids subtests demonstrated good intra-rater agreement between time points. Conclusions Somatosensory capacity increased with age for typically developing children aged 6–15 years. Three subtests of the SenScreen Kids demonstrated good intra-rater reliability with typically developing children. Further investigation of reliability is required, and all subtests require psychometric testing with clinical populations.
The Dr Elizabeth Casson Memorial Lecture 2018: Occupational stories from a global city
Authors: Pollard Nick 
Published: July 2018

The Dr Elizabeth Casson Memorial Lecture 2018, given on June 12th2018 at the 42nd Annual Conference and Exhibition of the Royal College of Occupational Therapists, held at the Belfast Waterfront, Belfast, UK.This lecture aims to set out the potential for the global occupational therapy profession to exchange knowledge for social transformation practice. It identifies the profession’s concern with narratives as a vehicle for a socially critical approach to occupation, which can be used to negotiate intervention and action. Drawing on examples from literature, history and service users, the paper suggests that narrative provides a means for relating the value of occupation beyond professional boundaries to capture popular imagination and demand for the profession. Examples are given of the critical discussion of the everyday impact of health inequity, and in addressing diversity both in the profession and engaging service users.My lecture concludes that occupational therapy is a global network with the population of a city, and thus represents a community that can be a vibrant voice for social transformation through occupation through a reciprocal exchange of narrative. This is a collective and dialogical process which can draw on the experiences of both southern and northern hemispheres.
Entrepreneurial orientation in family firms: New drivers and the moderating role of the strategic involvement of the board
Authors: Arzubiaga Unai , Maseda Amaia , Iturralde Txomin 
Published: July 2018

In this study, we examine new drivers that generate a disposition toward entrepreneurial activity in family firms and how the strategic involvement of the board of directors (SIBD) moderates the relationships between these drivers (image of the firm, willingness to change, and access to financial resources) and entrepreneurial orientation (EO). Using a sample of 230 family small and medium-sized enterprises (SMEs), our results confirm that a good family firm image and willingness to change may be powerful tools that stimulate a firm to develop entrepreneurial activities. The negative relationship between access to financial resources and EO may relate to the false belief that financial resources help firms be more creative and to maintaining family control of the firm and the socioemotional endowment. Contrary to our expectations, we also find that the SIBD negatively influences the relationship between the above drivers and EO, pointing to the need for more open boards of directors in family SMEs in order to develop and implement entrepreneurial strategies. JEL Classification: L2, M1
Adverse Radiographic Outcomes Following Operative Treatment of Medial Malleolar Fractures
Authors: Hu Jianping , Zhang Chunlin , Zhu Kunpeng , Zhang Lei , Wu Weiping , Cai Tao , Ma Xiaolong 
Published: July 2018

Background: We initiated a retrospective study on ankle fractures to assess (1) the time needed for fracture union; (2) the incidence of adverse radiographic outcomes (AROs); (3) factors that might lead to AROs; and (4) whether AROs were associated with worse function and higher incidence of post-trauma osteoarthritis (PTOA). Methods: From 2007 to 2016, a total of 296 patients (169 women, 127 men; average age, 48.6 years; range, 20-84) were diagnosed with a medial malleolar fracture, whether isolated or in the setting of bi- or trimalleolar fractures, and underwent open reduction and internal fixation (ORIF) or percutaneous screw fixation (PSF). The interval to fracture union, radiographic outcomes, American Orthopaedic Foot & Ankle Society (AOFAS) score at 6 months postoperatively, and the incidence of PTOA were recorded. Risk factors were identified both in univariate and multivariate analysis. The average follow-up period was 52.0 months (range, 12-118). Results: The incidence of delayed union, nonunion, and malunion were 20.3%, 3.7%, and 4.4%, respectively. The interval to fracture union was 10.3 ± 6.4 weeks. In the multivariate analysis, the risk factors for AROs were tobacco use, vertical fractures, interposed soft tissue, and fair/poor reduction. Patients with AROs had significantly worse AOFAS score at 6 months postoperatively ( P < .001) and higher incidence of PTOA ( P < .001). Conclusion: AROs of medial malleolar fractures have an underestimated incidence rate and are associated with worse ankle function and higher incidence of PTOA. Risk factors including tobacco use, vertical fractures, interposed soft tissue, poor/fair reduction should be prudently taken into consideration when treating medial malleolar fractures. Level of Evidence: Level III, retrospective cohort study.
A case of gemcitabine-related acute lipodermatosclerosis
Authors: Nyckowski Tim , McGregor Sean , Huang William W 
Published: July 2018

Introduction Gemcitabine is a chemotherapeutic agent used to treat several solid organ malignancies. The most common cutaneous toxicities are a mild erythematous rash and pruritus, which are often attributed to infectious etiologies. However, certain clinical characteristics may favor a drug-related reaction. Clinicians should recognize these phenomena to avoid potentially unnecessary antibiotic treatment or withdrawal of chemotherapeutic agents. Objective We aim to report a case of gemcitabine-related acute lipodermatosclerosis-like eruption, add to the evolving classification of this condition, and highlight developing literature on gemcitabine that may explain this toxicity. Case Dermatology was consulted for presumed cellulitis in a 62-year-old female with pancreatic carcinoma. The patient presented to the emergency department five days after her first dose of gemcitabine with erythema in both lower extremities. A diagnosis of gemcitabine-related acute lipodermatosclerosis was made and the patient was started on topical triamcinolone. Conclusion It is important to recognize gemcitabine-related acute lipodermatosclerosis in order to avoid unnecessary antibiotic use and disruptions in chemotherapy.
Debunking a myth: The Greek language in Cyprus is not being destroyed. A linguistic analysis of Cypriot Greek–English codeswitching
Authors: Fotiou Constantina 
Published: July 2018

Aims and objectives: This paper examines Cypriot Greek–English codeswitching practices by Cypriot-born Greek Cypriots and investigates its linguistic forms, functions and codeswitching types. It also assesses the frequency of English in the data. Methodology: The data consist of authentic, informal conversations. Codeswitching is regarded as the use of two languages by one speaker in a single conversation, so established borrowings were excluded from the analysis. For assessing frequency, a word-count was conducted and for data analysis the distinction between insertions and alternations was used. Data and analysis: Forty hours of naturally occurring conversations among Greek Cypriots were studied. Data are categorised according to codeswitching types, linguistic forms and functions of English. Findings/conclusions: Quantitatively, English use is limited. Thus claims for excessive use of English are unfounded. Structurally, codeswitching mainly takes the form of English insertions in a Cypriot Greek grammatical structure. Most codeswitching is intra-sentential, with mostly English nouns and noun phrases used. Single-word switching is more frequent than multi-word switching. Originality: This study, to the author’s knowledge, is the first thorough documentation of oral Cypriot Greek–English codeswitching by Greek Cypriots born and raised in Cyprus and the first study addressing the assertions for the ‘destruction of the Greek language in Cyprus’ using a large sample of empirical data. Significance/implications: As Greek Cypriots’ native language but not the standard official language of the state, Cypriot Greek has been accused of being ‘susceptible’ to a heavy use of English because it supposedly lacks the richness of Standard Modern Greek. This work shows that such heavy use is only in the mind of purists and that claims about Cypriot Greek speakers’ linguistic deficit on the basis of purported dense codeswitching are unfounded.
The role of inflammation in the association between gestational diabetes and obstructive sleep apnea: A pilot study
Authors: Bublitz MH , Carpenter M , Amin S , Okun ML , Millman R , De La Monte SM , Bourjeily G 
Published: July 2018

Background Obstructive sleep apnea is associated with pregnancy complications including gestational diabetes. Mechanisms underlying the association between obstructive sleep apnea and gestational diabetes remain to be elucidated. Methods Twenty-three participants with gestational diabetes underwent home sleep apnea testing. Obstructive sleep apnea was defined as an apnea hypopnea index > 5. Fasting morning blood samples were measured using multianalyte profiling (xMAP) multiplexed bead array immunoassay for Interleukin 6, tumor necrosis factor-alpha, and Interleukin 8. Results Age, body mass index, and gestational age at enrollment were 31 + 4.4 years, 35.7 + 7.4 kg/m2, and 28 ± 4 weeks, respectively. Participants were 52% Caucasian and 16% had obstructive sleep apnea. We observed positive correlations between apnea hypopnea index and Interleukin 6 (r = 0.62, p = 0.005), Interleukin 8 (r = 0.56, p = .56), and tumor necrosis factor-alpha (r = .58, p = .009). Women with obstructive sleep apnea had higher levels of Interleukin 6 (F = 5.01, p = .037) and Interleukin 8 (F = 6.33, p = .021) vs. women without obstructive sleep apnea. Conclusion These preliminary results indicate that in women with gestational diabetes, apnea hypopnea index is associated with an elevated inflammatory profile.
Outcomes of adult urethroplasty with commercially available acellular matrix
Authors: Pearlman Amy Marcia , Mujumdar Vaidehi , McAbee Kara Elizabeth , Terlecki Ryan Patrick 
Published: July 2018

Background: Reconstruction for complex urethral strictures may necessitate grafting. Buccal mucosal graft (BMG) harvest involves additional morbidity, making ‘off-the-shelf’ options attractive. Multiple extracellular matrices (ECMs) have been used with varying degrees of success. We reviewed our experience with MatriStem (ACell, Inc., Columbia, MD, USA) to assess safety and clinical/histologic outcomes. Methods: All patients undergoing acellular matrix-based reconstruction were included. Data regarding indications for surgery, patient demographics, subsequent procedures, clinical outcomes, and histologic analysis, when present, were collected. Results: Eight patients undergoing urethral reconstruction with ECM were identified. All repairs were performed as staged procedures. Grafting was performed with either MatriStem alone or MatriStem and concomitant BMG. Seven patients (88%) underwent prior endoscopic intervention and five patients (71%) had failed to respond to one or multiple prior urethroplasties. Length of involved segments ranged from 2.5 to 15 cm. ECM graft placement was feasible and demonstrated excellent graft take. Among patients undergoing second-stage repairs (four of eight, 50%), 50% remained patent without the need for subsequent dilation. Conclusions: Use of acellular matrix grafts in urethral reconstruction appears safe and feasible. Acellular matrix performs similarly to BMG with respect to graft take and contraction following staged repair. Further study is warranted.
Focus on fathers: paternal depression in the perinatal period
Authors: Glasser S , Lerner-Geva L 
Published: July 2018

Aims: This report aims to present a concise overview and synthesis of current research findings regarding paternal depression in the perinatal period. Methods: A literature search was conducted, primarily via PubMed and PsychNET, for English-language research studies and meta-analyses using combinations of the terms ‘perinatal’, ‘pregnancy’, ‘postpartum’, ‘depression’ AND ‘fathers’ OR ‘paternal’. Peer-reviewed articles were considered, and a representative sample of literature, with an emphasis on recent publications from a broad range of populations was summarized for each of the following sub-sections: prevalence, risk factors, impact on the infant/child, and healthcare costs. Results: Reported prevalence has ranged from 2.3% to 8.4%, with a significant degree of heterogeneity in rates, due to differences in multiple aspects of the methodology (timing, instruments, etc.). Nevertheless, rates of maternal depression remain higher than paternal depression, and higher rates of one are associated with higher rates of the other. The primary risk factors for paternal depression are maternal depression and the father’s history of severe depression, or symptoms of depression or anxiety prenatally. Biological mechanisms may underlie paternal depression, with changes reported in testosterone, cortisol and prolactin levels during this period. Paternal depression has been related to children’s behavioral, emotional and social function at 36 months and psychiatric disorders at 7 years, adjusting for maternal depression. Healthcare costs may also be impacted by paternal postpartum depression, with higher father–child dyad costs found after controlling for potential confounders. Conclusions: Focusing on fathers’ emotional well-being in the perinatal period is important in itself, as well as for their wives and children. Programs recommending screening for maternal perinatal mood and anxiety disorders should include inquiry regarding the father’s emotional state, and if his distress is reported it should be clarified and followed-up by support and intervention as necessary.