bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurturing Youth: Ethical Considerations in Pediatric Skincare Marketing
Authors: Madhumita Monisha , Ponnarasu Subitchan 
Published: November 2024

ABSTRACTIn today's beauty‐obsessed culture, children are increasingly targeted by skincare marketing, raising significant ethical concerns. The trend of children adopting skincare routines focused on anti‐aging and skin lightening impacts their mental health and self‐esteem, often imposing unattainable beauty standards. Marketing practices in the digital age frequently violate the International Chamber of Commerce (ICC) Framework for Responsible Marketing Communication. Disparities in skincare marketing particularly affect children in low‐ and middle‐income countries. There is an urgent need for stringent regulations, enhanced media literacy education, and ethical marketing practices to safeguard young consumers and prioritize their well‐being and dignity.
Fear of the Cancer Coming Back: A Metasynthesis of Fear of Recurrence in Breast Cancer
Authors: Wang Kai‐Yue , Li Hui , Qin Nan 
Published: November 2024

ABSTRACTObjectiveThis review aimed to consolidate existing knowledge on this phenomenon by incorporating direct testimonies from individuals who have experienced breast cancer.MethodsA thorough metasynthesis of qualitative studies was conducted. English articles published prior to September 18 2023 were searched from eight databases, including PubMed, Cochrane Library, Web of Science, Embase, the Chinese biomedical literature service system, the China National Knowledge Infrastructure, the Wanfang Database, and the Wipu Database. After screening the titles, abstracts, and full texts, six articles were finally included in the quality appraisal and metaaggregation.ResultsA total of 30 research findings were distilled and integrated into three themes: causes of fear of cancer recurrence (FCR); feelings of FCR; coping with FCR; and six subthemes: disease treatment factors; psychological factors; FCR is worry and fear; overcoming; negative response; positive response.ConclusionsFCR is a subjective feeling; it is influenced by the interplay between the external environment (adjuvant therapy) and internal environment (psychological factors). Therefore, future care measures should be designed comprehensively, considering the individual characteristics of breast cancer survivors and the external environment. This could be the primary focus for addressing FCR in cancer patients in the future.
Community Nursing Practice in Hypertension Management in China: Qualitative Analysis Using a Bourdieusian Framework
Authors: Li Bo 
Published: November 2024

ABSTRACTObjectiveThis study explores the practices of Chinese community nurses in hypertension management, using Pierre Bourdieu's theory of practice to understand how their routines are shaped by sociocultural and institutional forces, along with their professional dispositions.DesignA qualitative descriptive study was conducted in Shenzhen, China, between March and June 2024, and is reported following the COREQ guidelines.SampleEighteen nurses, each with at least 1 year of full‐time experience in hypertension care within the local community healthcare system, were recruited from a participant pool established through prior research.MeasurementsFace‐to‐face individual semistructured interviews were conducted using a structured interview protocol, and data were analyzed through thematic analysis.ResultsCommunity nurses face tensions between traditional health beliefs and modern hypertension care, as well as institutional pressures that prioritize efficiency over personalized care. Power imbalances, particularly the authority of doctors, complicate their role. However, nurses adapt their care strategies through embodied practices, balancing clinical standards with patient needs.ConclusionsCommunity nurses are not mere enforcers of guidelines but adaptive professionals who navigate complex sociocultural norms, institutional demands, and power dynamics in hypertension care. This study underscores the necessity for flexible, culturally sensitive practices to improve public health outcomes.
Mito‐TEMPO Demonstrates Protective Effect Against Ultraviolet Radiation‐Induced Skin Damage in Wistar Rats
Authors: Shetty Sachin , Deepak Kingsly , Tambe Prasad Kisan , Udupi Anushree , Bharati Sanjay 
Published: November 2024

ABSTRACTBackgroundMitochondria could be an important target for ultraviolet radiation (UVR)‐induced skin damage. Therefore, protecting mitochondria using mitochondria‐targeted antioxidants may protect skin from UV‐induced photodamage.MethodsIn the present study, UVR‐induced skin damage model was developed by irradiating male Wistar rats with UVB at a dose of 120 mJ/cm2, twice a week for a period of 5 weeks. Mito‐TEMPO was administered intraperitoneally (0.1 mg/kg b.w.) twice a week for 5 weeks. After 5 weeks of treatment period, animals were sacrificed and the dorsal skin tissues were collected. Physical examinations of the skin for analyzing wrinkle formation and epidermal thickening were carried out. Skin tissues were used for the evaluation of histopathological changes, mitochondrial dysfunction analysis, and mitochondrial membrane potential.ResultsPhysical and histological examination showed that mito‐TEMPO protected from the damaging effect of UVB radiation. A significant increase in mitochondrial reactive oxygen species (mtROS) generation with a concomitant increase in mitochondrial lipid peroxidation (mtLPO) was observed in UV‐irradiated groups. UV‐induced generation of mtROS and mtLPO formation was effectively reduced by mito‐TEMPO. Mito‐TEMPO pre‐treatment improved mitochondrial complex II activity, which was significantly reduced in the UV‐irradiated group.ConclusionThe results suggested that mito‐TEMPO effectively protected skin tissue against UV‐induced oxidative stress and damage.
GATA3 expression in tumor‐infiltrating mononuclear inflammatory cells is associated with poor prognostic factors in tubo‐ovarian carcinomas
Authors: Nili Fatemeh , Mirzaian Elham , Doustmohammadi Tahereh , Moradpanah Somayeh , Ameli Fereshteh , Sarmadi Soheila , Momeni Niusha 
Published: November 2024

AbstractThe study investigated the expression of GATA3, a transcription factor involved in immune regulation, in tubo‐ovarian carcinomas and its association with clinicopathological factors and prognosis. Immunohistochemical analysis was performed on 91 tubo‐ovarian carcinoma samples to determine the presence of GATA3‐positive inflammatory cells in the tumor microenvironment. A threshold of 10% or higher was considered a positive expression. The results showed that 46.7% of tubo‐ovarian carcinomas exhibited positive expression of GATA3 in inflammatory cells. There was no significant difference in GATA3 expression between patients who received pre‐surgical chemotherapy and those who underwent primary surgery. However, high‐grade serous carcinomas had a significantly higher proportion of GATA3‐positive inflammatory cells compared to other subtypes. Advanced‐stage tumors (stage III) had a higher percentage of GATA3‐positive inflammatory cells compared to stage II and I tumors. Patients with positive GATA3 expression had a significantly lower disease‐free survival rate. However, there was no significant association between GATA3 expression and chemotherapy response score. These findings suggest that increased expression of GATA3 in mononuclear inflammatory cells is associated with higher grade, advanced stage, and increased risk of recurrence in tubo‐ovarian carcinoma. This implies that heightened GATA3 expression negatively impacts anti‐tumor immunity, tumor growth progression, and invasiveness in tubo‐ovarian carcinomas.
Characterization of virus species associated with sweet potato virus disease in Costa Rica and riboprobe development for its rapid detection
Authors: Méndez‐Navarro Daniela , Chacón‐Cerdas Randall , Alvarado‐Ulloa Carlos , Camacho‐Montero José Roberto , Sánchez‐Navarro Jesús Ángel , Alvarado‐Marchena Luis 
Published: November 2024

AbstractSweet potato (Ipomoea batatas) is a crucial crop for food security and economic stability in many regions, including Costa Rica. This study aimed to assess the prevalence and genetic diversity of two major viruses associated with sweet potato virus disease (SPVD) in Costa Rica: sweet potato feathery mottle virus (SPFMV) and sweet potato chlorotic stunt virus (SPCSV). A total of 50 leaf samples displaying typical viral disease symptoms were collected from major sweet potato‐growing regions. Using multiplex reverse transcription (RT)‐PCR, SPFMV was detected in 82% of the samples and SPCSV in 52%, with a coinfection rate of 48%. Genetic analysis revealed that SPFMV isolates belonged predominantly to phylogenetic group B, while SPCSV isolates clustered with the West African (WA) strain. The low genetic diversity within these viral populations suggests a limited number of initial infection events followed by local spread. Riboprobe technology was evaluated as an alternative to RT‐PCR for virus detection. While the riboprobes for SPFMV demonstrated sensitivity comparable to RT‐PCR, the SPCSV riboprobes showed slightly lower sensitivity, particularly when using crude leaf extracts. Despite this, riboprobes offer significant advantages in terms of cost and ease of use for large‐scale screening. Our findings underscore the need for robust diagnostic and management strategies to control SPVD and highlight the importance of continuous monitoring and research to mitigate the impact of viral diseases on sweet potato production in Costa Rica. These insights contribute to the global understanding of SPVD and support collaborative efforts in plant pathology research.
The Discretionary Power of Street‐Level Bureaucrats From the Perspective of Illusio
Authors: Crosby Andrew 
Published: November 2024

ABSTRACTInterrogating the tension between care and control in the work of social services staff in Belgian immigration detention centres, this article sheds light on the uses of discretion from the perspective of Bourdieu's concept of illusio. I argue that social services staff's use of discretionary power must be understood at the crossroads of their belief in their professional ethos and the power relations within these centres, which enabled them to frame the element of control as something they had to deal with professionally, rather than something to which they contributed. This sheds light on both the uses of discretion as well as on the articulation of care and control in border humanitarianism.
Simulation‐based assessment in the context of paramedic education: A scoping review
Authors: Bell Steve 
Published: November 2024

AbstractObjectiveSimulation is a widespread modality in the field of medical education. Within the paramedic sphere, simulation is valuable in providing exposure to high‐acuity, low occurrence incidents encountered rarely in practice, affording unique educational opportunities. Recognising this importance, this scoping review seeks to establish the contemporaneous evidence base for the use of simulation‐based assessment in the context of paramedic education, systematically map the research done in this area and consider the implications for future educational programmes.MethodsA scoping review of peer, and non‐peer reviewed literature across a broad range of medical literature databases for both published and grey material utilising previously published search filters for the paramedic field. The review was conducted aligned to the PRISMA Extension for Scoping Reviews checklist. Studies were selected based on relevance to the research question.ResultsTwenty four unique papers were identified, filtered via the application of inclusion and exclusion criteria to five included papers. The application of forward snowballing methodology revealed three additional papers included for appraisal. Thematic analysis of the eight papers revealed the domains of assessment acceptability and assessment validity as key considerations for the design and use of simulation‐based assessment in the field.ConclusionSimulation‐based assessment has a role in paramedic education; additional research is necessary to empirically establish the validity and reliability of the modality in the field.
Implementation of digital chest radiography for childhood tuberculosis diagnosis at district hospital level in six high tuberculosis burden and resources limited countries
Authors: Melingui Bernard Fortune , Basant Joshi , Taguebue Jean voisin , Massom Douglas Mbang , Leroy Terquem Etienne , Norval Pierre Yves , Salomao Angelica , Dim Bunnet , Tek Chhen Eap , Borand Laurence , Khosa Celso , Moh Raoul , Mwanga‐Amumpere Juliet , Eang Mao Tan , Manhiça Ivan , Mustapha Ayeshatu , Balestre Eric , Beneteau Samuel , Wobudeya Eric , Marcy Olivier , Orne‐Gliemann Joanna , Bonnet Maryline ,   the TB‐Speed Decentralization Study Group
Published: November 2024

AbstractObjectivesChest x‐ray (CXR) plays an important role in childhood tuberculosis (TB) diagnosis, but access to quality CXR remains a major challenge in resource‐limited settings. Digital CXR (d‐CXR) can solve some image quality issues and facilitate their transfer for quality control. We assess the implementation of introducing d‐CXR in 12 district hospitals (DHs) in 2021–2022 across Cambodia, Cameroon, Ivory Coast, Mozambique, Sierra Leone and Uganda as part of the TB‐speed decentralisation study on childhood TB diagnosis.MethodsFor digitisation of CXR, digital radiography (DR) plates were setup on existing analogue radiography devices. d‐CXR were transferred to an international server at Bordeaux University and downloaded by sites' clinicians for interpretation. We assessed the uptake and performance of CXR services and health care workers' (HCW) perceptions of d‐CXR implementation. We used a convergent mixed method approach utilising process data, individual interviews with 113 HCWs involved in performing or interpreting d‐CXRs and site support supervision reports.ResultsOf 3104 children with presumptive TB, 1642 (52.9%) had at least one d‐CXR, including 1505, 136 and 1 children with one, two and three d‐CXRs, respectively, resulting in a total of 1780 d‐CXR. Of them, 1773 (99.6%) were of good quality and 1772/1773 (99.9%) were interpreted by sites' clinicians. One hundred and sixty‐four children had no d‐CXR performed despite attending the radiography department: 126, 37 and 1 with one, two and three attempts, respectively. d‐CXRs were not performed in 21.6% (44/203) due to connectivity problem between the DR plate captor and the computer. HCW reported good perceptions of d‐CXR and of the DR plates provided. The main challenge was the upload to and download from the server of d‐CXRs due to limited internet access.Conclusiond‐CXR using DR plates was feasible at DH level and provided good quality images but required overcoming operational challenges.
Improvement in photosynthesis under different light intensities is highly linked to domestication stages in cotton
Authors: Lei Zhangying , Jia Mengmeng , Wang Heng , Carriquí Marc , Niinemets Ülo , Chen Yunrui , He Yang , Li Ziliang , Sun Dongsheng , He Ziqi , Li Xiafei , He Daohua , Zhang Wangfeng , Liu Fang , Zhang Yali 
Published: November 2024

SUMMARYDomestication has dramatically increased crop size and biomass, reflecting the enhanced accumulation of photosynthates. However, we still lack solid empirical data on the impacts of domestication on photosynthetic rates at different light intensities and on leaf anatomy, and of the relationships of photosynthesis with aboveground biomass. In this study, we measured the photosynthetic rate at three photosynthetic photon flux densities of 2000 (high), 1000 (moderate) and 400 μmol m−2 sec−1 (low light intensity), dark respiration, relative chlorophyll content (SPAD), leaf morphology, and aboveground biomass in 40 wild, 91 semiwild, and 42 domesticated cotton genotypes. The study was replicated for two years (growing years 2018 and 2019). During the first domestication stage (transition from wild to semiwild genotypes), domestication led to higher photosynthetic rates measured under high light intensity, higher SPAD, larger leaf area (LA), and lower leaf mass per unit area (LMA), contributing to greater aboveground biomass accumulation in both study years. During the second domestication stage (transition from semiwild to domesticated genotypes), domestication significantly enhanced photosynthesis under low light intensity and reduced LMA, which were associated with increased aboveground biomass in both study years. In conclusion, photosynthesis improvement at different light intensities has been a gradual domestication phase specific process with the rate of photosynthesis enhanced under high light during the first domestication stage, and under low light during the second domestication stage. We argue that these differences reflect a higher proportion of LA photosynthesizing under low light due to enhanced canopy expansion at the second domestication stage.
Genome‐wide associated study identifies FtPMEI13 gene conferring drought resistance in Tartary buckwheat
Authors: He Jiayue , Hao Yanrong , He Yuqi , Li Wei , Shi Yaliang , Khurshid Muhammad , Lai Dili , Ma Chongzhong , Wang Xiangru , Li Jinbo , Cheng Jianping , Fernie Alisdair R. , Ruan Jingjun , Zhang Kaixuan , Zhou Meiliang 
Published: November 2024

SUMMARYTartary buckwheat is known for its ability to adapt to intricate growth conditions and to possess robust stress‐resistant properties. Nevertheless, it remains vulnerable to drought stress, which can lead to reduced crop yield. To identify potential genes involved in drought resistance, a genome‐wide association study on drought tolerance in Tartary buckwheat germplasm was conducted. A gene encoding pectin methylesterase inhibitors protein (FtPMEI13) was identified, which is not only associated with drought tolerance but also showed induction during drought stress and abscisic acid (ABA) treatment. Further analysis revealed that overexpression of FtPMEI13 leads to improved drought tolerance by altering the activities of antioxidant enzymes and the levels of osmotically active metabolites. Additionally, FtPMEI13 interacts with pectin methylesterase (PME) and inhibits PME activity in response to drought stress. Our results suggest that FtPMEI13 may inhibit the activity of FtPME44/FtPME61, thereby affecting pectin methylesterification in the cell wall and modulating stomatal closure in response to drought stress. Yeast one‐hybrid, dual‐luciferase assays, and electrophoretic mobility shift assays demonstrated that an ABA‐responsive transcription factor FtbZIP46, could bind to the FtPMEI13 promoter, enhancing FtPMEI13 expression. Further analysis indicated that Tartary buckwheat accessions with the genotype resulting in higher FtPMEI13 and FtbZIP46 expression exhibited higher drought tolerance compared to the others. This suggests that this genotype has potential for application in Tartary buckwheat breeding. Furthermore, the natural variation of FtPMEI13 was responsible for decreased drought tolerance during Tartary buckwheat domestication. Taken together, these results provide basic support for Tartary buckwheat breeding for drought tolerance.
Effects of phosphorylation on CsTT12 transport function: A comparative phosphoproteomic analysis of flavonoid biosynthesis in tea plants (Camellia sinensis)
Authors: Wang Na‐Na , Xiu Ke‐Yan , Deng Min , Liu Qi‐Yun , Jin Di‐Di , Zhao Qiao‐Mei , Su Huang‐Qiang , Qiu Ting‐ting , Wang Hai‐Yan , Liu Ya‐Jun , Jiang Xiao‐Lan , Xia Tao , Gao Li‐Ping 
Published: November 2024

SUMMARYMonomeric flavan‐3‐ols and their oligomeric forms, proanthocyanidins (PAs), are closely related to the bitterness of tea beverages. Monomeric flavan‐3‐ols are characteristic flavor compounds in tea. Increasing the content of PAs and anthocyanins enhances the resistance of tea plants to pathogen invasion but decreases the quality of tea beverages. MATE family transporters play a critical role in transferring monomeric flavan‐3‐ols and anthocyanins into vacuoles for storage or subsequent condensation into PAs. Their activities modulate the ratio of monomeric flavan‐3‐ols to PAs and increase anthocyanin content in tea plants. In this study, it was observed that the gene expression and protein phosphorylation level of the MATE transporter CsTT12, a vacuole‐localized flavonoid transporter, were notably upregulated following exogenous sucrose treatment, promoting PA synthesis in tea plants. Further analysis revealed that overexpression of CsTT12 and CsTT12S17D significantly increased the content of anthocyanins and PAs in plants, whereas CsTT12S17A did not. In CsTT12 knockdown plants, PA's accumulation decreased significantly, while monomeric catechin content increased. Moreover, phosphorylation modification enhanced the vacuolar membrane localization of CsTT12, whereas dephosphorylation weakened its vacuolar membrane localization. This study uncovers the crucial role of phosphorylation in flavonoid biosynthesis and provides insights into balancing quality improvements and resistance enhancement.
A factorization of the GJMS operators of special Einstein products and applications
Authors: Case Jeffrey S. , Malchiodi Andrea 
Published: November 2024

AbstractWe show that the GJMS operators of a special Einstein product factor as a composition of second‐ and fourth‐order differential operators. In particular, our formula applies to the Riemannian product . We also show that there is an integer such that if , then for any special Einstein product , the Green's function for the GJMS operator of order is positive. As a result, these products give new examples of closed Riemannian manifolds for which the ‐Yamabe problem is solvable.
Equivariant orientation of vector bundles over disconnected base spaces
Authors: Bhattacharya Prasit , Zou Foling 
Published: November 2024

AbstractIn this paper, we view the equivariant orientation theory of equivariant vector bundles from the lenses of equivariant Picard spectra. This viewpoint allows us to identify, for a finite group , a precise condition under which an ‐orientation of a ‐equivariant vector bundle is encoded by a Thom class. Consequently, we are able to construct a generalization of the first Stiefel–Whitney class of a “homogeneous” ‐equivariant bundle with respect to an ‐ring spectrum . As an application, we show that the 2‐fold direct sum of any homogeneous bundle is ‐orientable, where is the Burnside Mackey functor. We notice that ‐orientability is equivalent to ‐orientability when the order of is odd. When the order of is even, we show that a ‐equivariant analog of the tautological line bundle over is ‐orientable but not ‐orientable.
The slice spectral sequence for a motivic analogue of the connective K(1)$K(1)$‐local sphere
Authors: Kong Hana Jia , Quigley J. D. 
Published: November 2024

AbstractWe compute the 2‐adic effective slice spectral sequence (ESSS) for the motivic stable homotopy groups of , a motivic analogue of the connective ‐local sphere over prime fields of characteristic not two. Together with the analogous computation over algebraically closed fields, this yields information about the motivic ‐local sphere over arbitrary base fields of characteristic not two. To compute the spectral sequence, we prove several results that may be of independent interest. We describe the ‐differentials in the slice spectral sequence in terms of the motivic Steenrod operations over general base fields, building on analogous results of Ananyevskiy, Röndigs, and Østvær for the very effective cover of Hermitian K‐theory. We also explicitly describe the coefficients of certain motivic Eilenberg–MacLane spectra and compute the ESSS for the very effective cover of Hermitian K‐theory over prime fields.