bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opening the Audiobook
Authors: van Maas Sander 
Published: August 2018

Abstract
This essay investigates what the word “book” in the concept of the audiobook has come to refer to, and how contemporary material book cultures suggest ways to reperceive audiobook experience. The essay uses audiobooks by David Foster Wallace and Jacques Derrida, which appear to maintain complex yet normative relations to their printed editions, to show how the margins of the audiobook are brought into focus by raising the question of aurality. What does the audiobook suggest in terms of its relation to technologies of listening, hearing, and overhearing? Suggesting that the audiobook’s insistence on the book is matched by its adherence to experiences of phantasmatic aural centeredness, the essay turns to ways in which the book’s materiality might inspire a reaffirmation of the interaural. Case studies include book alterations by Doug Beube and an electronic composition by Yannis Kyriakides, which suggest ways to reperceive audiobookness as a form of sonic tabularity.
Transgender Shifts
Authors: Chatterjee Shraddha 
Published: August 2018

Abstract
A larger game is at play with respect to the field of transgender subjectivities in India that goes beyond gender or sexuality, and enters the arena of contested cultures and historical erasures. It can be hypothesized that a contemporary transgender subject in India finds itself caught between the fading voice of precolonial and colonial history on the one hand, and the strong pull of globalization on the other, creating what can perhaps be imagined as a knotted relation of the (transgender) subject with historicity and temporality. A rather confounding gap lies between premodern conceptualizations of gender and sexuality that reside as cultural memory in the subject, carrying its own paleonymic weight, and the increasingly widening signifier transgender in the contemporary. The task of this article is to explore what can be found at this interstice, which promises a clue that is symptomatic of the shifting sands of culture, history, and memory as they play out in India, and how they may point toward a theorization of sexuality that lies away from its histories in the West.
Chinese Trans Advocates Organize Nationally
Authors: Bernotaite Ausma , Berredo Lukas , Zhuo H.c 
Published: August 2018

Abstract
The trans movement in mainland China is at its early stages and rapidly growing. Particularly in the past two years, there has been a strong rise in trans activism and advocacy. There have been more trans individuals willing to be publicly visible, and more efforts are being made within the larger LGB community to support the articulation of trans communities. In December 2016, a two-day conference with trans activists and advocates was held in the eastern Chinese city of Ningbo, aiming at not only facilitating exchange to support participants' work but also initiating a community-based consultation to map out the current situation of trans people across the country. This article seeks to present the qualitative information gathered during the event in regard to the communities' most pressing needs in order to provide an informed direction for the trans movement in the country.
Modeling Niemann-Pick disease type C1 in zebrafish: a robust platform for in vivo screening of candidate therapeutic compounds
Authors: Tseng Wei-Chia , Loeb Hannah E. , Pei Wuhong , Tsai-Morris Chon-Hwa , Xu Lisha , Cluzeau Celine V. , Wassif Christopher A. , Feldman Benjamin , Burgess Shawn M. , Pavan William J. , Porter Forbes D. 
Published: August 2018

ABSTRACT
Niemann-Pick disease type C1 (NPC1) is a rare autosomal recessive lysosomal storage disease primarily caused by mutations in NPC1. NPC1 is characterized by abnormal accumulation of unesterified cholesterol and glycolipids in late endosomes and lysosomes. Common signs include neonatal jaundice, hepatosplenomegaly, cerebellar ataxia, seizures and cognitive decline. Both mouse and feline models of NPC1 mimic the disease progression in humans and have been used in preclinical studies of 2-hydroxypropyl-β-cyclodextrin (2HPβCD; VTS-270), a drug that appeared to slow neurological progression in a Phase 1/2 clinical trial. However, there remains a need to identify additional therapeutic agents. High-throughput drug screens have been useful in identifying potential therapeutic compounds; however, current preclinical testing is time and labor intensive. Thus, development of a high-capacity in vivo platform suitable for screening candidate drugs/compounds would be valuable for compound optimization and prioritizing subsequent in vivo testing. Here, we generated and characterize two zebrafish npc1-null mutants using CRISPR/Cas9-mediated gene targeting. The npc1 mutants model both the early liver and later neurological disease phenotypes of NPC1. LysoTracker staining of npc1 mutant larvae was notable for intense staining of lateral line neuromasts, thus providing a robust in vivo screen for lysosomal storage. As a proof of principle, we were able to show that treatment of the npc1 mutant larvae with 2HPβCD significantly reduced neuromast LysoTracker staining. These data demonstrate the potential value of using this zebrafish NPC1 model for efficient and rapid in vivo optimization and screening of potential therapeutic compounds.
This article has an associated First Person interview with the first author of the paper.
MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins
Authors: Planchon Damien , Rios Morris Eduardo , Genest Mallory , Comunale Franck , Vacher Sophie , Bièche Ivan , Denisov Evgeny V. , Tashireva Lubov A. , Perelmuter Vladimir M. , Linder Stefan , Chavrier Philippe , Bodin Stéphane , Gauthier-Rouvière Cécile 
Published: August 2018

ABSTRACT
Tumor cell invasion and metastasis formation are the major cause of death in cancer patients. These processes rely on extracellular matrix (ECM) degradation mediated by organelles termed invadopodia, to which the transmembrane matrix metalloproteinase MT1-MMP (also known as MMP14) is delivered from its reservoir, the RAB7-containing endolysosomes. How MT1-MMP is targeted to endolysosomes remains to be elucidated. Flotillin-1 and -2 are upregulated in many invasive cancers. Here, we show that flotillin upregulation triggers a general mechanism, common to carcinoma and sarcoma, which promotes RAB5-dependent MT1-MMP endocytosis and its delivery to RAB7-positive endolysosomal reservoirs. Conversely, flotillin knockdown in invasive cancer cells greatly reduces MT1-MMP accumulation in endolysosomes, its subsequent exocytosis at invadopodia, ECM degradation and cell invasion. Our results demonstrate that flotillin upregulation is necessary and sufficient to promote epithelial and mesenchymal cancer cell invasion and ECM degradation by controlling MT1-MMP endocytosis and delivery to the endolysosomal recycling compartment.
Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX
Authors: Oeding Stefanie J. , Majstrowicz Katarzyna , Hu Xiao-Ping , Schwarz Vera , Freitag Angelika , Honnert Ulrike , Nikolaus Petra , Bähler Martin 
Published: August 2018

ABSTRACT
Mitochondrial distribution in cells is critical for cellular function and proper inheritance during cell division. In mammalian cells, mitochondria are transported predominantly along microtubules by kinesin and dynein motors that bind indirectly via TRAK1 and TRAK2 to outer mitochondrial membrane proteins Miro1 and Miro2 (Miro1/2). Here, using proximity labelling, we identified Miro1/2 as potential binding partners of myosin XIX (Myo19). Interaction studies show that Miro1 binds directly to a C-terminal fragment of the Myo19 tail region and that Miro1/2 recruit the Myo19 tail in vivo. This recruitment is regulated by the nucleotide state of the N-terminal Rho-like GTPase domain of Miro1/2. Notably, Myo19 protein stability in cells depends on its association with Miro1/2. Downregulation of Miro1/2 or overexpression of the adaptor proteins TRAK1 and TRAK2 caused a reduction in Myo19 protein levels. Myo19 regulates the subcellular distribution of mitochondria, and downregulation, as well as overexpression, of Myo19 induced perinuclear collapse of mitochondria, phenocopying loss of the kinesin KIF5, dynein or their mitochondrial receptors Miro1/2. These results suggest that Miro1 and Miro2 coordinate microtubule- and actin-based mitochondrial movement.
This article has an associated First Person interview with the first author of the paper.
Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults
Authors: HARA MEGUMI , HACHIYA TSUYOSHI , SUTOH YOICHI , MATSUO KEITARO , NISHIDA YUICHIRO , SHIMANOE CHISATO , TANAKA KEITARO , SHIMIZU ATSUSHI , OHNAKA KEIZO , KAWAGUCHI TAKAHISA , OZE ISAO , MATSUDA FUMIHIKO , ITO HIDEMI , KAWAI SAYO , HISHIDA ASAHI , OKADA RIEKO , SASAKABE TAE , HIRATA AKIE , IBUSUKI RIE , NINDITA YORA , FURUSYO NORIHIRO , IKEZAKI HIROAKI , KURIYAMA NAGATO , OZAKI ETSUKO , MIKAMI HARUO , NAKAMURA YOHKO , SUZUKI SADAO , HOSONO AKIHIRO , KATSUURA-KAMANO SAKURAKO , ARISAWA KOKICHI , KURIKI KIYONORI , ENDOH KAORI , TAKASHIMA NAOYUKI , KADOTA AYA , NAKATOCHI MASAHIRO , MOMOZAWA YUKIHIDE , KUBO MICHIAKI , NAITO MARIKO , WAKAI KENJI 
Published: August 2018

ABSTRACT

Purpose
Although several genetic factors may play a role in leisure-time exercise behavior, there is currently no evidence of a significant genomewide association, and candidate gene replication studies have produced inconsistent results.

Methods
We conducted a two-stage genomewide association study and candidate single-nucleotide polymorphisms (SNP) association study on leisure-time exercise behavior using 13,980 discovery samples from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, and 2036 replication samples from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center-2 study. Leisure-time physical activity was measured using a self-administered questionnaire that inquired about the type, frequency and duration of exercise. Participants with ≥4 MET·h·wk−1 of leisure-time physical activity were defined as exhibiting leisure-time exercise behavior. Association testing using mixed linear regression models was performed on the discovery and replication samples, after which the results were combined in a meta-analysis. In addition, we tested six candidate genetic variants derived from previous genomewide association study.

Results
We found that one novel SNP (rs10252228) located in the intergenic region between NPSR1 and DPY19L1 was significantly associated with leisure-time exercise behavior in discovery samples. This association was also significant in replication samples (combined P value by meta-analysis = 2.2 × 10−9). Several SNP linked with rs10252228 were significantly associated with gene expression of DPY19L1 and DP19L2P1 in skeletal muscle, heart, whole blood, and the nervous system. Among the candidate SNP, rs12612420 in DNAPTP6 demonstrated nominal significance in discovery samples but not in replication samples.

Conclusions
We identified a novel genetic variant associated with regular leisure-time exercise behavior. Further functional studies are required to validate the role of these variants in exercise behavior.
Blunted Cardiac Output from Overtraining Is Related to Increased Arterial Stiffness
Authors: COATES ALEXANDRA M. , MILLAR PHILIP J. , BURR JAMIE F. 
Published: August 2018

ABSTRACT

Purpose
Moderate overtraining has been characterized by decreased exercising HR and recently decreased exercising stroke volume (SV), independent of alterations to blood volume. The aim of this study was to assess changes in arterial stiffness and central hemodynamics, and their relationship to exercising SV, after 3 wk of overload training.

Methods
Twenty-six cyclists and triathletes completed 3 wk of either regular training (CON; n = 13) or overload training (OL; n = 13). Testing took place before (PRE) and after regular or overload training (POST). Resting measures included brachial blood pressure, HR, carotid–femoral pulse wave velocity (PWV) to assess arterial stiffness, and carotid pulse wave analysis to assess wave reflections and central hemodynamics. An incremental cycle test was used to assess peak power, maximal HR, and maximal lactate to assess overtraining status. Cardiac output (Q˙), SV, and HR were assessed using cardiac impedance.

Results
Resting arterial stiffness was unaltered in CON but increased with OL after increased training (CON −0.1 ± 0.6 m·s−1 vs OL +0.5 ± 0.8 m·s−1, P = 0.04). Resting blood pressure and central hemodynamics, including aortic pressures, augmentation index, and subendocardial viability ratio, did not change (all P > 0.05). Maximal SV (CON +3 mL vs OL −9 mL, P = 0.04), HR (CON −2 ± 4 bpm vs OL −9 ± 3 bpm, P < 0.001), and Q˙ (CON +0.32 L·min−1 vs OL −1.75 L·min−1, P = 0.01) decreased with OL from PRE to POST. A significant inverse relationship existed between changes in PWV and maximal Q˙ (r = −0.44, P = 0.04) and changes in PWV and peak power (r = −0.48, P = 0.01), and trended for SV and PWV (r = −0.41, P = 0.055).

Conclusions
Overload training results in increased resting arterial stiffness and reduced SV during exercise, with no changes to resting central hemodynamics.
Process Capability and Data Contamination
Authors: Tošenovský Filip , Tošenovský Josef 
Published: August 2018

Purpose: The paper centres on process capability and its relation to data contamination. Process capability may be distorted due to imprecise data. The paper analyses to what extent capability changes reflect problems in data so that the changes can be attributed to data sampling rather than the true performance of the process. This is important because it is usually much simpler to increase the precision of data sampling than the process itself.Methodology/Approach: The paper has two major parts. In part one, effect of data contamination on the observed process characteristic is analysed. The effect is analysed using data obtained from simulated random drawings and the chi-squared test. In the other part, reaction of capability to data contamination is observed. The capability is measured by a univariate capability index.Findings: Regarding the sensitivity of the index to contamination, it is different depending on the capability before the contamination. This leads to conclusions about when the company using the index should focus more on the way the data is measured, and when it should focus more on improving the process in question. The analysis shows that if the company is used to high levels of capability and records its drop, it is worth analysing its measurement system first, as the index is at higher levels more sensitive to data contamination.Research Limitation/implication: The study concerns a single univariate index, and the contamination is modelled with only several probability distributions. Originality/Value of paper: The findings are not difficult to detect, but are not known in practice where companies do not realize that problems with their process capability may sometimes lie in the data they use and not in the process itself.
Influence of Silica (SiO2) Loading on the Thermal and Swelling Properties of Hydrogenated-Nitrile-Butadiene-Rubber/Silica (HNBR/Silica) Composites
Authors: Amin Muhammad , Khattak Abraiz , Ali Muhammad 
Published: August 2018

AbstractHydrogenated-Nitrile-Butadiene-Rubber (HNBR) is known for its good physical strength. It is a widely used rubber in electrical insulation and other high performance applications. Performance of HNBR is affected in high temperature and an aggressive fluid environment. Adding silica to HNBR may overcome this problem. In order to investigate the effect of fluids and temperature on HNBR/silica composites we prepared multiple composites of HNBR with 8.3, 16.7, 33.4, 50 and 66.7 phr of silica (SiO2) by two roll compounding method. Swelling index and thermo gravimetric analyses were performed. Calculations of swelling indexes were performed at different time periods with ethanol, toluene and water. For thermo gravimetric analysis (TGA), thermo grams of samples were obtained and % char yields at 550 °C were analyzed for all samples. Improvements with the addition of silica were recorded up to a great extent in both analyses. Swelling index decreased with the addition of silica as compared to neat HNBR and reached an optimum position with 50 phr silica loading in ethanol, 8.3 phr in water and 66.7 phr in toluene. Moreover, the HNBR composite with 66.7 phr of silica was found to be the highest thermally stable sample and lost less than 60% of weight at 550 °C in comparison to neat HNBR in which 80% of weight loss occurred at 550 °C.
Humorous sublimation of a dying Cuban writer in Reinaldo Arenas’ The Color of Summer
Authors: Panichelli Christophe , Panichelli-Batalla Stéphanie 
Published: August 2018

Abstract
How does a human being deal with suffering? How can we emotionally cope with the vicissitudes of life, especially in times where they suddenly multiply themselves? In this study, we present an innovative interdisciplinary study on the use of coping mechanisms by career writers dealing with difficult life events. We focus in particular on the use of humor and sublimation, two creative mental mechanisms that contribute to the lowering of anxiety while at the same time dealing constructively with the external stressors. Never before have these mechanisms been studied in a complementary way in the context of a literary study. This paper offers an in-depth analysis of Reinaldo Arenas’ The Color of Summer. In this novel, this Cuban author introduces an autobiographical perspective of the Cuban sixties and seventies, intending to present a facet of history that would never appear in Cuban history books. The combination of both coping mechanisms, which we call humorous sublimation, offers a novel that not only helped the author cope with his tormented life, but also allowed the reader to gain an understanding of a dark period of Cuban history by means of a very funny and surreal reading.
A lower energetic, protein and uncooked cornstarch intake is associated with a more severe outcome in glycogen storage disease type III: an observational study of 50 patients
Authors: Ben Chehida Amel , Ben Messaoud Sana , Ben Abdelaziz Rim , Mansouri Hajer , Boudabous Hela , Hakim Kaouthar , Ben Ali Nadia , Ben Ameur Zeineb , Sassi Yosra , Kaabachi Neziha , Abdelhak Sonia , Abdelmoula Mohamed Slim , Azzouz Hatem , Tebib Neji 
Published: August 2018

Abstract

Background
Glycogen storage disease type III (GSDIII), due to a deficiency of glycogen debrancher enzyme (GDE), is particularly frequent in Tunisia. Phenotypic particularities of Tunisian patients remain unknown. Our aim was to study complications of GSDIII in a Tunisian population and to explore factors interfering with its course.

Methods
A retrospective longitudinal study was conducted over 30 years (1986–2016) in the referral metabolic center in Tunisia.

Results
Fifty GSDIII patients (26 boys), followed for an average 6.75 years, were enrolled. At the last evaluation, the median age was 9.87 years and 24% of patients reached adulthood. Short stature persisted in eight patients and obesity in 19 patients. Lower frequency of hypertriglyceridemia (HTG) was associated with older patients (p<0.0001), higher protein diet (p=0.068) and lower caloric intake (p=0.025). Hepatic complications were rare. Cardiac involvement (CI) was frequent (91%) and occurred early at a median age of 2.6 years. Severe cardiomyopathy (50%) was related to lower doses of uncooked cornstarch (p=0.02). Neuromuscular involvement (NMI) was constant, leading to a functional discomfort in 64% of cases and was disabling in 34% of cases. Severe forms were related to lower caloric (p=0.005) and protein intake (p<0.015).

Conclusions
A low caloric, protein and uncooked cornstarch intake is associated with a more severe outcome in GSDIII Tunisian patients. Neuromuscular and CIs were particularly precocious and severe, even in childhood. Genetic and epigenetic factors deserve to be explored.
Bayesian hierarchical models for predicting individual performance in soccer
Authors: Egidi Leonardo , Gabry Jonah 
Published: August 2018

AbstractAlthough there is no consensus on how to measure and quantify individual performance in any sport, there has been less development in this area for soccer than for other major sports. And only once this measurement is defined, does modeling for predictive purposes make sense. We use the player ratings provided by a popular Italian fantasy soccer game as proxies for the players’ performance; we discuss the merits and flaws of a variety of hierarchical Bayesian models for predicting these ratings, comparing the models on their predictive accuracy on hold-out data. Our central goals are to explore what can be accomplished with a simple freely available dataset comprising only a few variables from the 2015–2016 season in the top Italian league, Serie A, and to focus on a small number of interesting modeling and prediction questions that arise. Among these, we highlight the importance of modeling the missing observations and we propose two models designed for this task. We validate our models through graphical posterior predictive checks and we provide out-of-sample predictions for the second half of the season, using the first half as a training set. We use Stan to sample from the posterior distributions via Markov chain Monte Carlo.
Crystal structure of catena-poly[diaqua-bis(μ2-3,5-di(1H-1,2,4-triazol-1-yl)benzoate-κ2
N:N′)cobalt(II))] 2.5 hydrate, C22H23CoN12O8.50
Authors: Lan Hong-Hong 
Published: August 2018

Abstract
C22H23CoN12O8.50, triclinic, P1̄ (no. 2), a = 9.6549(3) Å, b = 10.6027(4) Å, c = 13.4938(4) Å, α = 100.824(3)°, β = 99.707(3)°, γ = 96.642(3)°, V = 1321.76(8) Å3, Z = 2, R
gt(F) = 0.0366, wR
ref(F
2) = 0.0914, T = 288.03(10) K.
Study on the preparation and drug release property of soybean selenoprotein/carboxymethyl chitosan composite hydrogel
Authors: Hu Yong , Wu Xiao Y. , Xu Jin R. , Guo Juan 
Published: August 2018

Abstract
Soybean selenoprotein/carboxymethyl chitosan (SSP/CMCS) composite hydrogel obtained by the crosslinking of genipin was evaluated for caffeine release. The gelation process of the hydrogel was investigated by resonance Rayleigh scattering spectra and viscosity methods. The hydrogels presented a compact network structure, which was observed by positive fluorescence microscopy (PFM). The structural properties of the hydrogel were revealed by fluorescence and FT-IR. The swelling characteristic of the hydrogel and its application in the slow release of caffeine were also studied. These results indicate that there is obvious interaction between SSP and CMCS by the addition of genipin, and the CMCS/SSP solution experiences a significant sol-gel phase transition process upon polymerization. The swelling ratio and release of caffeine slow down obviously at pH 1.2. However, larger swelling and more drug release can be observed at pH 7.4. The experimental values of the empiric diffusional exponent show that the release profiles abide by the non-Fickian diffusion process under both investigated pH conditions. The hydrogel, which is pale transparent with light yellow color at room temperature, can be formulated to be a suitable carrier for site-specific drug delivery.