bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responder Analyses from a Phase 2b Dose-Ranging Study of Bremelanotide
Authors: Althof Stanley , Derogatis Leonard R. , Greenberg Sally , Clayton Anita H. , Jordan Robert , Lucas Johna , Spana Carl 
Published: July 2019

Abstract

Background
Responder analyses are used to determine whether changes that occur during a clinical trial are clinically meaningful; for subjective endpoints such as those based on patient-reported outcomes (PROs), responder analyses are particularly useful.

Aim
To identify the minimal clinically important difference (MCID) for selected scores on questionnaires assessing female sexual functioning and to use these differences to analyze the response in a large, controlled, phase 2b, dose-finding study of bremelanotide in premenopausal women with hypoactive sexual desire disorder (HSDD) and mixed HSDD/female sexual arousal disorder (FSAD).

Methods
The responder analyses were performed for the change from baseline to end of study for a total of 7 endpoints. Each PRO endpoint was assessed using at least 1 of 4 types of responder analyses: a planned analysis anchored to MCIDs based on expert estimates (historical anchors); post hoc analyses based on self-reported global benefit; receiver operating characteristic (ROC) curves; and cumulative distribution function. The prespecified analysis groups were all female sexual dysfunction (FSD)-based diagnoses (all study participants), those with HSDD alone, and a combined group of those with FSAD alone plus those with mixed HSDD/FSAD. Post hoc analyses were also performed for subjects with mixed HSDD/FSAD with a primary diagnosis of HSDD.

Outcomes
MCIDs based on the ROC curves for changes in Female Sexual Function Index–desire domain, Female Sexual Distress Scale–Desire/Arousal/Orgasm (FSDS-DAO) total score, FSDS-DAO item 13 and 14 scores, and number of satisfying sexual events.

Results
Outcomes matched those based on input from clinical experts. For all 7 endpoints, responder rates at the 1.75 mg dose in the overall modified intention-to-treat population achieved statistical significance compared with placebo (P ≤ .03).

Clinical Implications
These responder definitions were subsequently used in the bremelanotide phase 3 registration studies (RECONNECT) that evaluated the safety and efficacy of the bremelanotide 1.75 mg subcutaneous dose in premenopausal women with HSDD.

Strengths & Limitations
MCIDs for this study were based on changes from a single-blind phase to account for changes due to the placebo effect. These analyses were restricted to a study population composed only of premenopausal women with a clinical diagnosis of HSDD and/or FSAD and were based on data from the same clinical trial.

Conclusion
Bremelanotide was safe and well tolerated and demonstrated significant improvement in efficacy vs placebo in the phase 2b trial. The multiple responder analyses offer a valuable approach for determining clinically important effects of bremelanotide for HSDD and FSAD.
Can Botulinum-A Toxin Be Used to Delay Ejaculation: Results of an Ejaculation Model in Male Rats
Authors: Ongün Şakir , Acar Selin , Koca Pelin , Uzut Mehmet , Esen Ahmet Adil , Durmus Nergiz , Demir Omer 
Published: July 2019

ABSTRACT

Introduction
Although premature ejaculation (PE) is the most common sexual dysfunction in young men, its true pathophysiology has not yet been clearly elucidated.

Aim
To investigate the quantitative changes that occurred in an ejaculation model induced by para-chloroamphetamine (PCA) after botulinum-A toxin injection into the bulbospongiosus (BS) muscle in rats.

Methods
A total of 21 male rats weighing 300 to 350 grams were used in the study. The animals were divided into 3 groups: control, 1 unit of botulinum-A toxin injected, and 5 units of botulinum-A toxin injected. The botulinum-A toxin was percutaneously injected into the BS muscle, and the experiment was carried out 96 hours (5 days) after the injection.

Main Outcome Measure
The seminal vesicle (SV) was cannulated, and the BS muscle was dissected and connected to an amplifier (Biopac; Goleta, CA) to record the pressure and electromyography measurement. The ejaculation parameters were obtained after the PCA injection.

Results
The ejaculation latency time of the group receiving 5 units of botulinum-A toxin was statistically significantly longer (1092 ± 657 seconds) compared to the control group (298 ± 81 seconds) and the group receiving 1 unit of botulinum-A toxin (439 ± 100 seconds) (P = .003). Furthermore, the BS EMG area under the curve values for the group receiving 5 units of botulinum-A toxin were significantly lower (7.4 ± 1.2 V/s × 10–4) than those of the control group (13.6 ± 4.0 V/s × 10–4) and the group receiving 1 unit of botulinum-A toxin (13.6 ± 5.0 V/s × 10–4) (P = .009). No statistically significant difference was found between the groups in terms of the basal SV pressure, number of SV phasic contractions, maximum amplitude of the SV phasic contraction, and intervals between the SV phasic contractions and the BS muscle contractions.

Clinical Implications
Botulinum-A toxin injection is a potential treatment option for PE and should be further investigated by future clinical studies.

Strengths and Limitations
Ease of administration and prolonged duration of botulinum-A toxin are advantages of the existing treatment options. The risk of anejaculation due to the dosage should be kept in mind.

Conclusions
Injection of botulinum-A toxin into the BS muscle in rats significantly delayed the ejaculation latency time and affected the expulsion phase.
Are stories just as transporting when not in your native tongue?
Authors: CHUNG-FAT-YIM ASHLEY , CILENTO ELENA , PIOTROWSKA EWELINA , MAR RAYMOND A. 
Published: July 2019

abstractWe spend much of our time consuming stories across different types of media, often becoming deeply engaged or transported into these stories. However, there has been almost no research into whether processing a story in one’s non-native language influences our level of transportation. We analyzed three existing datasets in order to compare engagement with English-language stories for those who reported English as their first language and those who reported English as their second language. Stories were presented as text (Study 1), audio (Study 2), and short films (Study 3). Across all studies, equivalent levels of narrative transportation between language groups were found, even after accounting for age and years of English fluency. These results are in contrast to some previous proposals that emotional reactions are attenuated during non-native language processing, despite equivalent levels of comprehension. Our evidence indicates that individuals processing a narrative in their second language feel just as transported into the story as those processing the same narrative in their native language.
Effects of n-3 PUFA on endothelial function in patients with peripheral arterial disease: a randomised, placebo-controlled, double-blind trial
Authors: Hammer Alexandra , Moertl Deddo , Schlager Oliver , Matschuck Manuela , Seidinger Daniela , Koppensteiner Renate , Steiner Sabine 
Published: July 2019

AbstractAs only limited evidence is available for potential benefits of n-3 PUFA supplementation in patients with peripheral arterial disease (PAD), we studied the effects of 4 g n-3 PUFA on endothelial function and inflammatory markers. Seventy patients with stable PAD classified as Rutherford stage 2 or 3 and good control of cardiovascular factors were randomised to receive either 4 g n-3 PUFA or placebo daily for 3 months in a double-blind fashion. Primary endpoint was endothelial function assessed by flow-mediated vasodilation (FMD). In addition, ankle–brachial index, maximum and pain-free walking distances were determined. Lipid parameters including the omega-3 index reflecting n-3 PUFA intake as well as pro-inflammatory, endothelial and platelet activation markers were measured over the same time interval. After 3 months of treatment with 4 g n-3 PUFA daily, a significant improvement of FMD was observed compared with placebo (n-3 PUFA, median Δ 3·7 (interquartile range (IQR) –1·8, 7·1) % v. placebo, Δ –0·5 (IQR –6·5, 3·0) %, P = 0·01 between the groups). After a 3-month washout period, this benefit was not sustained (n-3 PUFA, median Δ 0·6 (IQR –2·2, 5·6) % v. placebo, Δ –0·9 (IQR –6·6, 6·7) %, P = 0·20). In response to n-3 PUFA, an improvement of lipid parameters with a pronounced increase in the omega-3 index was seen. No changes were found for other parameters. In conclusion, in patients with PAD, 4 g/d n-3 PUFA improved cardiovascular risk in PAD patients, which needs testing in large-scale trials.
The metabolic regulation of fenofibrate is dependent on dietary protein content in male juveniles of Nile tilapia (Oreochromis niloticus)
Authors: Ning L. , Liu Y. , Wang W. , Li Y. , Chen L. , Du Z.-Y. 
Published: July 2019

AbstractThe fenofibrate functions in mammals could be affected by many factors such as dietary nutrient levels and physiological status. However, this phenomenon has not been well studied in fish. The goal of our study was to investigate the effect of dietary protein contents on metabolic regulation of fenofibrate in Nile tilapia. An 8-week experiment was conducted to feed fish with four diets at two protein levels (28 and 38 %) with or without the supplementation of fenofibrate (200 mg/kg body weight per d). After the trial, the body morphometric parameters, plasma biochemical parameters and quantitative PCR data were examined. These results showed that fenofibrate significantly reduced the feeding intake and weight gain rate, increased the oxidative stress (increased plasma methane dicarboxylic aldehyde) and liver : body ratio (increased hepatosomatic index) in the low protein (LP)-fed fish. In contrast, fenofibrate exhibited a lipid-lowering (reduced hepatic lipid) effect and up-regulated the expressions of the genes related to lipid catabolism, transport and anabolic metabolism in the high protein (HP)-fed fish. The present study suggested that lipid-lowering effect of fenofibrate would be strengthened in the fish fed with the HP diet containing high energy, but in the fish fed with the LP diet containing low energy, the fenofibrate treatment would cause adverse effects for metabolism. Taking together, our study showed that the metabolic regulation of fenofibrate in Nile tilapia was dependent not only on feed energy content but also on dietary nutrient composition, such as dietary protein and/or lipid levels.
Unusual seawater composition of the Late Cretaceous Tethys imprinted in glauconite of Narmada basin, central India
Authors: Bansal Udita , Banerjee Santanu , Pande Kanchan , Ruidas Dhiren K. 
Published: July 2019

AbstractA detailed investigation of a glauconite bed within the Late Cretaceous Bryozoan Limestone Formation of the Bagh Group in central India, as well as the study of existing records, reveals the existence of a ‘glauconitic sea’ along the margins of the Palaeo-Tethys Ocean during the Late Cretaceous Epoch. The authigenic green mineral formed abundantly on shallow seafloors unlike in its modern, deep-sea counterpart. We present an integrated petrographical, geochemical and mineralogical investigation of the glauconite within Late Cretaceous transgressive deposits to highlight its unique geochemistry with moderate Fe2O3and high Al2O3, SiO2, MgO as well as K2O contents. X-ray diffractional parameters identify the ‘evolved to high evolved’ nature of the glauconite while Mössbauer spectroscopic study reveals the dominance of Fe3+compared to Fe2+in the atomic structure. The rare earth elements (REE) pattern of glauconite reveals moderate light-REE/heavy-REE (LREE/HREE) fractionation and weak negative Eu anomaly. The Ce anomaly of the glauconite indicates a sub-oxic diagenetic condition. We propose that Late Cretaceous glauconites formed within a shallow marine depositional setting across the Tethyan belt because of enhanced supply of K, Si, Al, Fe, Mg cations through continental weathering under the extant greenhouse climate.
Rural old-age social exclusion: a conceptual framework on mediators of exclusion across the lifecourse
Authors: Walsh Kieran , O'Shea Eamon , Scharf Thomas 
Published: July 2019

AbstractSocial exclusion amongst rural-dwelling older adults and the role of the diversity of people and places in mediating the construction of that exclusion has not been adequately investigated or conceptualised in the international literature. Consequently, how ageing in a rural community can function to disadvantage or protect older people remains poorly understood. With the aim of advancing conceptual understanding on rural old-age social exclusion, this article explores how exclusion is manifest in the lifecourse experiences of rural-dwelling older adults and the role of mediating factors in the construction of exclusion in different kinds of rural places. The analysis draws on ten rural case-study sites across Ireland and Northern Ireland, encompassing five kinds of rural communities: dispersed rural; remote rural; island rural; village rural; and near-urban rural. Data come from 106 interviews with older people ranging in age from 59 to 93 years. Rural old-age social exclusion is confirmed as a multi-dimensional construct, involving: social relations; service infrastructure; transport and mobility; safety, security and crime; and financial and material resources. This analysis demonstrates that social exclusion for rural-dwelling older people is multi-layered, and its prevalence and form is shaped by four mediating factors: individual capacities; lifecourse trajectories; place; and macro-economic forces. The findings are used to present a conceptual framework that emphasises the role of mediating forces on rural old-age social exclusion.
Research on Attitude Interpolation and Tracking Control Based on Improved Orientation Vector SLERP Method
Authors: Dong Mingjie , Yao Guodong , Li Jianfeng , Zhang Leiyu 
Published: July 2019

SummaryIn order to make the end of the three-axis platform follow the control command and achieve stable control of the end attitude, an improved orientation vector spherical linear interpolation (SLERP) method is proposed for the requirements, which specifically handles the position of the gimbal lock, so that the platform can move smoothly around the gimbal lock position. A three-axis platform with a camera at the end is set up for the validity of the proposed algorithm. At first, an adaptive speed measurement method based on incremental encoder is introduced, which can automatically adapt to high and low speed, and estimate the ultra-low speed to realize the speed measurement of large dynamic range, and this is used for the motion control of the three-axis platform. Then, the SLERP method for the quaternion interpolation on the starting and ending attitudes represented in quaternion is introduced in detail, and it is continuously improved in response to its existing problems for the platform. Finally, an orientation vector SLERP method is proposed, which uses viscosity factor and rejection factor to adjust the algorithm near the platform’s gimbal lock position. A tracking experiment was designed using the red ball as the following target detected by the designed target tracking algorithm using the camera, which verified the effectiveness of the attitude tracking control based on the proposed improved orientation vector SLERP.
Types of embedded graphs and their Tutte polynomials
Authors: HUGGETT STEPHEN , MOFFATT IAIN 
Published: July 2019

AbstractWe take an elementary and systematic approach to the problem of extending the Tutte polynomial to the setting of embedded graphs. Four notions of embedded graphs arise naturally when considering deletion and contraction operations on graphs on surfaces. We give a description of each class in terms of coloured ribbon graphs. We then identify a universal deletion-contraction invariant (i.e., a ‘Tutte polynomial’) for each class. We relate these to graph polynomials in the literature, including the Bollobás–Riordan, Krushkal and Las Vergnas polynomials, and give state-sum formulations, duality relations, deleton-contraction relations, and quasi-tree expansions for each of them.
Development of healthy and sustainable food-based dietary guidelines for the Netherlands
Authors: Brink Elizabeth , van Rossum Caroline , Postma-Smeets Astrid , Stafleu Annette , Wolvers Danielle , van Dooren Corné , Toxopeus Ido , Buurma-Rethans Elly , Geurts Marjolein , Ocké Marga 
Published: July 2019

AbstractObjective:To derive healthy and sustainable food-based dietary guidelines (FBDG) for different target groups in the Netherlands and describe the process.Design:Optimised dietary patterns for children, adolescents, adults and the elderly were calculated using an optimisation model. Foods high in saturated and trans-fatty acids, salt and sugar, and low in dietary fibre, were excluded. The dietary patterns resembled the current food consumption as closely as possible, while simultaneously meeting recommendations for food groups, nutrients, maximum limits for foods with a high environmental impact, and within 85 % of the energy requirement. Recommended daily amounts of food groups were based on the optimised dietary patterns and expert judgement.Setting:The Netherlands.Participants:FBDG were derived for Dutch people with different ages, genders, activity levels and food preferences.Results:For most target groups the optimisation model provided dietary patterns that complied with all requirements. For some food groups, the optimised amounts varied largely between target groups. For consistent messages to consumers, the optimised dietary patterns were adjusted to uniform recommendations per target group. Recommendations were visualised in the Wheel of Five. The advice is to eat the recommended amounts of foods according to the Wheel of Five and limit consumption of other foods.Conclusions:Based on an optimisation model, scientific evidence, information on dietary patterns and expert knowledge, we derived FBDG for different target groups. The Wheel of Five is a key food-counselling model that can help Dutch consumers to make their diets healthier and more environmentally sustainable.
The Conspiracy Mentality Scale
Authors: Stojanov Ana , Halberstadt Jamin 
Published: July 2019

Abstract. Beliefs in conspiracy theories, generally considered to be a unidimensional construct, are associated with negative outcomes. The existing measures of conspiracy theory beliefs have number of shortcomings. We present the development of a novel measure of the tendency to believe in conspiracy theories and report the discovery of a second factor that reflects rational skepticism. In Study 1 ( N = 500) we use item response theory to devise the final items. In Study 2 ( N = 202) we demonstrate the predictive validity of the two factors for different types of conspiracies. In Study 3 ( N = 308) we demonstrate convergent/divergent validity. In Study 4 ( N = 800) we demonstrate construct validity in three countries. Implications for the concept of conspiracy theory and conspiracy theory beliefs are discussed.
Attitudes Toward Open Science and Public Data Sharing
Authors: Abele-Brehm Andrea E. , Gollwitzer Mario , Steinberg Ulf , Schönbrodt Felix D. 
Published: July 2019

Abstract. Central values of science are, among others, transparency, verifiability, replicability, and openness. The currently very prominent Open Science (OS) movement supports these values. Among its most important principles are open methodology (comprehensive and useful documentation of methods and materials used), open access to published research output, and open data (making collected data available for re-analyses). We here present a survey conducted among members of the German Psychological Society ( N = 337), in which we applied a mixed-methods approach (quantitative and qualitative data) to assess attitudes toward OS in general and toward data sharing more specifically. Attitudes toward OS were distinguished into positive expectations (“hopes”) and negative expectations (“fears”). These were un-correlated. There were generally more hopes associated with OS and data sharing than fears. Both hopes and fears were highest among early career researchers and lowest among professors. The analysis of the open answers revealed that generally positive attitudes toward data sharing (especially sharing of data related to a published article) are somewhat diminished by cost/benefit considerations. The results are discussed with respect to individual researchers’ behavior and with respect to structural changes in the research system.
Perpetrator Religion and Perceiver’s Political Ideology Affect Processing and Communication of Media Reports of Violence
Authors: Habib Samia , Adelman Levi , Leidner Bernhard , Pasha Shaheen , Sibii Razvan 
Published: July 2019

Abstract. People’s interpretations of media reports about crimes may be biased by their motivations to construct and protect their worldviews and, relatedly, by criminals’ group membership. Two large-scale experiments ( Ns = 248 and 1,115) investigated how American adults interpret reports of crimes committed by either a Christian or Muslim, and how these interpretations depend on political ideology. Results show liberals attributing crimes more to religion for Christian rather than Muslim offenders, with the opposite effect for conservatives. Importantly, these biases also influenced how people communicated the news report to others. Additionally, evidence suggests that attitudes toward Islam and not toward Muslims may explain these effects. Implications for how political ideology affects interpretation and communication of media portrayals of Muslims are discussed.
Depth Determination of the 2010 El Mayor‐Cucapah Earthquake Sequence (M ≥ 4.0)
Authors: Yu Chunquan , Hauksson Egill , Zhan Zhongwen , Cochran Elizabeth S. , Helmberger Donald V. 
Published: July 2019

AbstractThe 2010 MW 7.2 El Mayor‐Cucapah earthquake ruptured a zone of ~120 km in length in northern Baja California. The geographic distribution of this earthquake sequence was well constrained by waveform relocation. The depth distribution, however, was poorly determined as it is near the edge of, or outside, the Southern California Seismic Network. Here we use two complementary methods to constrain the focal depths of moderate‐sized events (M ≥ 4.0) in this sequence. We first determine the absolute earthquake depth by modeling the regional depth phases at high frequencies (~1 Hz). We mainly focus on Pn and its depth phases pPn and sPn, which arrive early at regional distance and are less contaminated by crustal multiples. To facilitate depth phase identification and to improve signal‐to‐noise ratio, we take advantage of the dense Southern California Seismic Network and use array analysis to align and stack Pn waveforms. For events without clear depth phases, we further determine their relative depths with respect to those with known depths using differential travel times of the Pn, direct P, and direct S phases recorded for event pairs. Focal depths of 93 out of 122 M ≥ 4.0 events are tightly constrained with absolute uncertainty of about 1 km. Aftershocks are clustered in the depth range of 3–10 km, suggesting a relatively shallow seismogenic zone, consistent with high surface heat flow in this region. Most aftershocks are located outside or near the lower terminus of coseismic high‐slip patches of the main shock, which may be governed by residual strains, local stress concentration, or postseismic slip.