bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation, Development and Evaluation of Bilayer Floating Tablet of Gemfibrozil
Authors: Mohammad Gufran Mohammad Faizan , Ghatuary Sailesh Kumar , Shende Reena , Jain Prabhat Kumar , Parkhe Geeta 
Published: September 2019

Formulation development is an important part of drug design and development. Bioavailability and bioequivalence are totally dependent on formulation development. Now-a-days formulation development is done by following QbD (Quality by Design).The aim of present study is to formulate Gemfibrozil (Gem) sustained release (SR) and immediate release (IR) bilayer tablet by different concentration of Hydroxypropyl methylcellulose (HPMC) and HPMC K 100 M to control the release pattern. The sustained release layer of Gem was prepared by using different grades of HPMC like, HPMC K-15, HPMC K-4 along with other excipients by direct compression technique. The immediate release layer of Gem was prepared by Cross carmellose sodium, Crospovidone and Sodium starch glycolate by direct compression technique. The powders were evaluated for their flow properties and the finished tablets were evaluated for their physical parameters. The both immediate release and sustained release layers of Gem were characterized by FT-IR and in vitro dissolution studies. The drug release study of Gem was evaluated using USP-II paddle type dissolution apparatus. The release rate of Gem in immediate release layer was studied for 15 min in 0.1 N HCL media and that of Gem in sustained release layer was studied for 12 h in 0.1 N HCL. From the nine batches F6 batch showed good release behaviour 99.85% of drug is released over 12 hours. Gem belongs to BCS Class II (log P 3.6) with poor solubility and high permeability resulting in limited and variable bioavailability. Total four trial batches of each drug have been manufactured to optimize and develop a robust and stable formulation, the stability studies of the products also comply with ICH guideline.
Keywords: Bilayer floating tablets, Gemfibrozil, Biphasic drug release, HPMC K 15.
Alginate Microspheres: The Innovative Approaches to Production of the Microbeads/Micro-Particles
Authors: Ramana Reddy K. Venkata , Gupta Jaideep , Izharuddin Pathan 
Published: September 2019

Multiparticulate dosage form is pharmaceutical formulations where the active substance is in the form of a number of small independent subunit such as, granules, microparticle, beads, and microspheres. Multiparticulate drug delivery systems are specifically suitable for achieving delayed and sustained release oral formulations with a minimum risk of dose dumping, local irritation, systemic toxicity, and variation in rate of bioavailability as they are less dependent on gastrointestinal transit time and offers many advantages over unit particulate dosage forms. Microbeads are small, sphere shaped, systematically produced free-flowing properties, semi-spherical solid units. Microbeads are the agglomerates of about size ranging from 0.5 mm to 1.0 mm, obtained from various starting materials and utilizing different innovative techniques. A blend of multiparticulate can also be used to provide the desired drug release profile. These round shaped particles produced by mostly principle of atomization technique.Among various different innovative techniques Vibration technology, Electrostatic bead generator, Jetcutter technology, electrostatic forces, dropping method and a mechanical cutting device are few of many. In current article it describes about the total methods involved and their working principles with diagrams were clearly illustrated. Now a days sodium alginate beads were designed by these technologies mostly in relative to microencapsulation techniques.
Keywords: Atomization, Vibrating technology, Jetcutter device, Electrostatic bead generator Dropping method and electro-spray technology
Erken Çocukluk Çağı Çürüklerinin Önlenmesinde Annelerin Oral Hijyen Alışkanlıkları ve Çocuk Beslenmesi Konusunda Bilgi Düzeyinin ve Farkındalıklarının Belirlenmesi
Authors: Ünal Kocaman Gülhan , Çebi Ahmet Taylan 
Published: September 2019

Amaç: Çalışmamızın amacı; 0-6 yaş grubu çocuklarında erken çocukluk çağı diş çürüklerinin görülme sıklığının ve çürük oluşumuna neden olan faktörleri belirlenmesi ve 0-6 yaş grubundaki çocukların annelerin ağız ve diş sağlığı bilgi düzeylerinin, tutumlarının ve uygulamalarının çocuklardaki çürük gelişimi üzerindeki etkisini ortaya koymaktır. Materyal-Metot: Çalışmamıza, 0-6 yaş aralığında çocuğu bulunan 200 gönüllü anne dahil edilmiştir. Gönüllülere, sosyodemografik özellikleri, oral hijyen alışkanlıkları ve çocuğun beslenme alışkanlıkları konulu toplam 35 soru içeren anketler yönlendirilmiştir. Çocuklardaki mevcut diş çürükleri, araştırmacı hekimler tarafından tespit edilmiştir. Bulgular: Annelerin eğitim düzeylerinin çocuklarda görülen erken çocukluk çağı diş çürükleri ile ilişkili olduğu bulunmuştur (p&lt;0.01). Ailelerin yerleşim yerleri ile erken çocukluk çağı çürükleri arasında istatistiksel olarak anlamlı bir ilişki bulunmuştur (p&lt;0.05). Ailede bulunan çocuk sayısı ile diş çürüğü görülme sıklığı arasında anlamlı ilişki bulunmuştur (p&lt;0.01). Ailenin diş fırçalama alışkanlığı ile erken çocukluk çağı çürükleri arasında istatistiksel olarak anlamlı bir ilişki bulunmuştur (p&lt;0.05). Düzenli diş hekimi kontrolleri ile erken çocukluk çağı çürükleri arasında pozitif bir ilişki olduğu sonucuna varılmıştır (p&lt;0.05). Sonuç : Erken çocukluk çağı çürükleri önemli bir halk sağlığı sorunudur. Çalışmamızda, 0-6 yaş grubundaki çocukların annelerinin ağız sağlığına ilişkin bilgi düzeylerinin, ağız sağlığı tutumlarının ve çocuklarının beslenme alışkanlıklarının erken çocukluk çağı çürüğü oluşumunda etkili olabileceği bulunmuştur.
Reverse the Curse of the Top-5
Authors: Kaplan Robert S. 
Published: September 2019

SYNOPSIS
Faculty have increased the number of articles submitted to journals ranked in the top-5 of their discipline. This is their rational response to the overweighting of publications in top-5 journals by university promotions and tenure committees. Using journal impact factors, however, to infer the quality of a faculty member's publications incurs a high incidence of both Type 1 errors, when we conclude incorrectly that a paper published in a top-5 journal is a high-impact paper, and Type 2 errors, when we conclude that papers (and books) not published in these journals have low impact. A third type of error occurs when scholars underinvest in research about practice innovations because such research is viewed as unpublishable in top-5 journals. The paper suggests reforms to overcome the dysfunctional fixation on publication in top-5 journals.
Bonus Plan Choices During an Economic Downturn
Authors: Casas-Arce Pablo , Indjejikian Raffi J. , Matějka Michal 
Published: September 2019

ABSTRACT
We use survey data to estimate the effect of the 2008–2009 recession on three fundamental bonus plan choices. We find robust evidence that the recession (1) reduced incentive strength, (2) increased the relative incentive weight on financial performance measures, and (3) increased the perceived difficulty of financial performance targets, not only in absolute terms but also relative to the perceived difficulty of nonfinancial targets. To assess the extent to which these findings can be explained by standard theoretical explanations, we review prior agency literature and discuss several channels through which an economic downturn can affect firms' bonus plan choices. Our review highlights that contracting issues rarely examined in prior empirical work such as retention concerns and information asymmetry issues are likely to play an important role during an economic downturn.
PEMBELAJARAN MEMPRODUKSI TEKS CERITA PENDEK BERDASARKAN KURIKULUM 2013 DI KELAS XI IPB SMA NEGERI 1 SEMARAPURA
Authors: Swandewi Lita , Gunatama Gede , Astika Made 
Published: September 2019

Penelitian ini bertujuan mendeskripsikan perencanaan, pelaksanaan, dan evaluasi pembelajaran memproduksi teks cerita pendek berdasarkan kurikulum 2013 di kelas XI IPB SMA Negeri 1 Semarapura. Penelitian ini menggunakan rancangan deskriptif kualitatif. Subjek penelitian ini adalah guru bahasa Indonesia yang mengajar di kelas XI IPB dan siswa kelas XI IPB SMA Negeri 1 Semarapura. Objek penelitian ini adalah pembelajaran memproduksi teks cerita pendek. Metode pengumpulan data yang digunakan adalah dokumentasi, observasi, dan wawancara. Hasil penelitian ini menunjukkan, pertama, perencanaan pembelajaran memproduksi teks cerita pendek berdasarkan kurikulum 2013 di kelas XI IPB SMA Negeri 1 Semarapura sudah sesuai dengan komponen dan sistematika penyusunan RPP kurikulum 2013. Kedua, pelaksanaan pembelajaran memproduksi teks cerita pendek berdasarkan kurikulum 2013 di kelas XI IPB SMA Negeri 1 Semarapura sudah menggunakan pendekatan saintifik. Penerapan pendekatan saintifik dalam pembelajaran sudah melibatkan lima keterampilan, yaitu mengamati, menanya, mencoba, menalar, dan mengomunikasikan. Ketiga, evaluasi pembelajaran memproduksi teks cerita pendek berdasarkan kurikulum 2013 di kelas XI IPB SMA Negeri 1 Semarapura sudah sesuai dengan penilaian autentik. Dalam penilaian autentik evaluasi, dilakukan melalui 3 jenis penilaian, yaitu penilaian sikap, keterampilan, dan pengetahuan.
PENGGUNAAN INTERNET SEBAGAI MEDIA DALAM PEMBELAJAN BAHASA INDONESIA KELAS VII DI SMP NEGERI 4 SINGARAJA
Authors: Andryani Kd Zervina , Sriasih Sang Ayu Putu , Artika I Wayan 
Published: September 2019

Penelitian ini bertujuan untuk mengkajijenis media internet dan penggunaannya dalam pembelajaran bahasa Indonesia di SMP Negeri 4 Singaraja. Penelitian ini menggunakan rancangan penelitian deskriptif kualitatif.Pada penelitian ini subjek penelitian yang digunakan adalah gurubahasa Indonesia, siswa kelas VII A1 dan VII A2, serta internet.Sedangkan objek penelitian ini adalah jenis media internet dan penggunaan internet sebagai media pembelajaran. Jenis media internet dalam pelajaran bahasa Indonesia di SMP Negeri 4 Singaraja dilihat dari jenis media yang sering diguankan oleh guru pelajaran bahasa Indonesia. Sedangkan penggunaan internet sebagai media dalam pembelajaran bahasa Indonesia di SMP Negeri 4 Singaraja dilihat dari cara guru menggunakan media internet dalam pembelajaran. Hasil penelitian didapatkan dengan menggunakan metode observasi, dokumentasi, dan wawancara. Analisis data dilakukan dengan cara reduksi data, penyajian data, dan penarikan kesimpulan. Adapun hasil penelitian, yaitu (1) Jenis media internet yang digunakan adalah video dan teks, (2) video yang digunakan terdiri dari video cerita fantasi, video deskripsi, dan video prosedur. Sedangkan teks yang digunakan yaitu: teks deskripsi dan teks prosedur, (3)penggunaan media video digunakan dengan cara ditayangkan dan media teks digunakan sebagai contoh dalam bentuk hardcopy, (4) penggunaan internet sebagai media yang dilakukan oleh guru dan peserta didik kelas VII A1 dan VII A2 pada mata pelajaran bahasa Indonesia di SMP Negeri 4 Singaraja.
Manajemen Neuroanestesi pada Sindrom Dandy Walker dengan Hiperkalemia
Authors: Kulsum Kulsum , Mafiana Rose , Gaus Syafruddin 
Published: September 2019

Sindrom Dandy Walker termasuk hidrosefalus yang sangat jarang terjadi dengan insiden 1 kasus dari 65 kasus hidrosefalus berdasarkan penelitian profil hidrosefalus di RSUDZA Banda Aceh. Insiden di Indonesia sebanyak 50–60% kasus dari operasi bedah saraf. Kasus berikut seorang bayi laki-laki lahir prematur, umur 1 bulan, berat badan 3,5 kg, ukuran lingkar kepala 45 cm, muntah dan kejang. CT-Scan terdapat kista, kalium 7 mmol/l ditegakkan diagnosa sindrom Dandy Walker dengan hiperkalemia. Manajemen neuroanestesi dengan cara premedikasi dan pemasangan kateter intravena 24G dengan sevofluran via masker O2 100% setelah jalur vena terpasang, diberikan fentanil 10 mcg sebagai analgetik dan induksi propofol 10 mg. Rocuronium 3,5 mg sebagai fasilitas intubasi. Pemeliharaan anestesi dengan sevofluran dan oksigen. Ventilasi frekuensi nafas 30 x/menit dilakukan manual dan kemudian dengan ventilator TV 30 ml, I:E = 1:1,5, RR 30 kali per menit, FiO2 100%. Monitoring hasil frekuensi nadi 100 – 130 kali per menit, SpO2 100%, suhu afebris, CO2 30 mmHg. Simpulan: sindrom Dandy Walker kasus yang sangat jarang terjadi dan hidrosefalus sering bersamaan dengan hiperkalemia terjadi pada bayi prematur karena gangguan reaborbsi kalium dan terjadi perpindahan kompartemen dari intraseluler ke ekstraseluler sehingga kalium banyak di ekstraseluler, maka diperlukan manajemen neuroanestesi pediatrik yang adekuat. Neuroanesthesia Management in Dandy Walker Syndrome with HyperkalemiaAbstractDandy Walker syndrome including hydrocephalus which is a very rare case with the incidence of 1 case out of 65 cases of hydrocephalus based on a study of hydrocephalus profile at Zainal Abidin Hospital, Banda Aceh. The incidence of Dandy-Walker syndrome in Indonesia are about 50 - 60% cases from all of neurosurgical cases. The following case was a premature baby, 1 month old, weight 3.5 kg, head cicumference 45 cm, vomit and seizure. Cyst was found in the head CT scan and the potassium level of 7 mmol/l. The patient was diagnosed with Dandy-Walker Syndrome with hyperkalemia. Neuroanesthesia management by premedication and infusion using intravenous cathether 24G with sevoflurane and 100% O2 mask After succesful intravenous cathether, given fentanyl 10 mcg as analgesic and propofol 10 mg as induction. Rocuronium 3.5 mg as a facility for intubation. Maintenance of anesthesia with sevoflurane and oxygen. Respiratory rate 30 breaths per minute with ventilation that was done manually and then with TV on ventilator 30 ml, I: E = 1: 1.5, RR 30x/min, FiO2 100%. Monitoring pulse frequency results of 100–130 beats per minute, 100% SpO2, temperature afebrile, CO2 30 mmHg. Conclusions: Dandy-Walker Syndrome was a very rare case and hydrocephalus was often followed with hyperkalemia that occur in premature infants due to potassium reaboration disorder and the displacement of compartment from intracellular to extracellular so that potassium was abundant at extracellular, hence adequate pediatric neuroanesthesia management was needed.
THE METHOD OF MORAL EDUCATION IN CONSTRUCTING PERSONALITY ACCORDING TO ISLAM
Authors: Ashari Riza 
Published: September 2019

Nowadays, the moral degradation of muslim young generation is really in a sad matter. However, various negative effects coming from outer part, has caused moral crisis till brought this generation fallen into the depths of misery. For the sake of facing and challenging the negative influence of new century with all its sophisticated of its technology and its development, and to make this generation awake from this backwardness, moral education become the single way and solution which must be gone through to construct Islamic personality. That’s way the writer saw it was so important one to discuss about the method of moral education in constructing personality according to Islam.
Assessment of Gut Microbiota and Selected Blood Parameters in Weaned Piglets Following Supplementation with a Probiotic and Vitamin C
Authors: Tymczyna Leszek , Trawińska Beata , Kowaleczko Marta , Chmielowiec-Korzeniowska Anna , Lechowski Jerzy 
Published: September 2019

Abstract
The aim of the study was to assess the gut microbiota and selected haematological and biochemical blood parameters of weaned piglets following dietary supplementation with a probiotic and vitamin C. the piglets were divided into a control group (group C) and an experimental group (group E), with 30 piglets in each group. All animals received the same feed ad libitum. The animals in the control group (group C) received feed with no added probiotic and vitamin C. the piglets in the experimental group (group E) were given a supplement containing a probiotic (Bacillus cereus 1×109 CFU/kg) in the amount of 1.5 g/piglet/day and vitamin c in the amount of 300 mg/piglet/day. The supplement was administered for 28 days. The total numbers of bacteria of the family Enterobacteriaceae and of the genus Lactobacillus were determined in faeces. The erythrocyte count, haemoglobin level, haematocrit, leukocyte count, and percentages of neutrophils and lymphocytes were determined in the blood. The biochemical analysis concerned the concentration of triacylglycerols, total cholesterol, and LDL and HDL cholesterol. In group E a significant decrease (P<0.01) in the total number of Enterobacteriaceae bacteria was observed in the faeces of the piglets, accompanied by an increase in the number of lactobacilli relative to group C. E. coli was found to predominate over other microorganisms. Salmonella choleraesuis bacteria were present in the faeces of both groups before administration of the supplement, but were not found after its use. The supplement with probiotic and vitamin C caused a significant increase in the erythrocyte, haemoglobin and haematocrit levels in the blood of the piglets and a significant decrease in the concentration of triacylglycerols, total cholesterol and LDL cholesterol.
A new type of slumping-induced soft-sediment deformation structure: the envelope structure
Authors: Byun Uk Hwan , van Loon A.J. Tom , Kwon Yi Kyun , Ko Kyoungtae 
Published: September 2019

Abstract
The sediments of the Cretaceous Gyeokpori Formation in south-western South Korea accumulated in a lake in which mainly siliciclastic rocks were deposited, with some interbedded volcaniclastics. The nearby volcanic activity resulted in unstable lake margins inducing a dominance of gravity-flow deposits. The high sedimentation rate facilitated soft-sediment deformation on the sloping margin. The deposition of numerous gravity-flow deposits resulted in a vertically heterolithic stratification. The slumps are composed of different lithologies, which is expressed in different types of deformation due to the difference in cohesion between sandy and mussy layers within the slumps. Coarser-grained (cohesionless) slumps tend to show more chaotic deformation of their lamination or layering. The difference in slumping behaviour of the cohesive and non-cohesive examples is explained and modelled.
A unique soft-sediment deformation structure is recognized. This structure has not been described before, and we call it ‘envelope structure’. It consists of a conglomerate mass that has become entirely embedded in fine-grained sediment because slope failure took place and the fine-grained material slumped down with the conglomerate ‘at its back’. The cohesive laminated mudstone formed locally slump folds that embedded the non-cohesive overlying conglomerate unit, possibly partly due to the bulldozing effect of the latter. This structure presumably can develop when the density contrast with the underlying and overlying deposits is exceptionally high. The envelope structure should be regarded as a special – and rare – type of a slumping-induced deformation structure.
Optimisation of Permanent Magnets of Bioreactor Magnetic Coupling while Preserving their Efficiency
Authors: Konuhova M. , Kamolins E. , Orlova S. , Suleiko A. , Otankis R. 
Published: September 2019

Abstract
The paper discusses issues related to the optimisation of magnetic couplings used in bioreactors (manufactured by JSC “Biotehniskais Centrs”). The purpose of optimisation was to preserve the maximum breakaway torque of the magnetic coupling while reducing the mass of rare earth elements used in its structure. The paper presents the rationale for the selected optimisation option taking into account the economic aspect. To solve the optimisation problem, the factors affecting the maximum torque of the magnetic coupling, such as the shape and height of the internal and external magnets, the angle of the external and internal magnets, as well as the height of the internal and external yoke, were determined. The design of the existing magnetic coupling was optimised and its prototype was made based on the results of optimisation. The results obtained by means of optimisation were compared with the results obtained experimentally by testing the manufactured prototype.
Computer Simulations of the Band Structure and Density of States of the Linear Chains of NaCl Ions
Authors: Myasnikova L.N. , Istlyaup A.S. , Sergeyev D.M. , Zhanturina N.N. , Shunkeyev K.Sh. , Popov A.I. 
Published: September 2019

Abstract
The paper presents the results of first-principles computer simulations of the band structure, the density of states, and the total energy of NaCl (NaCl, Na2Cl2, Na3Cl3, Na4Cl4, Na6Cl6) linear chains of atoms. Modelling of the specified characteristics is realised in the computer code Atomistix ToolKit combined with Virtual NanoLab. The total energy depends on the number of ions in the nanoobject under study, but practically does not depend on the geometric arrangement of ions.
Embedded image processing on Raspberry Pi connected to the industrial control system
Authors: Hrbček Jozef , Bubeníková Emília 
Published: September 2019

Abstract
This paper deals with the image processing from the camera for Raspberry Pi connected with real-time communication network to the control system (PLC). The low time delay for receiving and sending commands, data, etc. is very important in the automating production processes. This can be provided by industrial real-time network based on Ethernet. The Ethernet POWERLINK, which is supported on B&R PLCs, is one of them. It is a simple solution for a variety of applications because the POWERLINK is publicly available as the open source. Connecting the PLC and Raspberry Pi with Ethernet POWERLINK opens up many applications in industrial automation. For example, image data obtained using a camera attached to Raspberry Pi can be used to sense image of manufacturing processes and products and evaluate their quality in industrial automation. This article focuses on an image processing unit and the PLC system with CPU redundancy used in the industrial application. Vision systems are often used to improve products quality control, saving costs and time.
Influences on plasma cutting quality on CNC machine
Authors: Kudrna Lukas , Fries Jiri , Merta Marek 
Published: September 2019

Abstract
This article discusses plasma cutting technology and its influences on the quality of the resulting cut. Plasma or a plasma arch consists of positive and negatively charged particles, excited and neutral atoms and molecules. As it contains free particles, it is electrically conductive and thus subject to the effects of the electrical and magnetic field. The basis of CNC machine design is described in the article, which has at least 3 axes (x, y, z), but there are also more technologically demanding applications, such as pipe cutting, profile and cutting using chamfer to prepare surfaces for welding, where these multi-axis devices are frequently used. The principle of plasma cutting and the plasma cutting phase is described in this article. The materials that can be divided by a plasma arc are described in detail, including graphs displaying the dependence of sheet thickness on the cutting speed. The article describes and lists the gases that are used in plasma-arc cutting, such as oxygen, argon, hydrogen and nitrogen. Important components of plasma cutting technology are the parameters that can be adjusted and set before the cutting so that the cut is of good quality. The most comprehensive chapter deals with the influences that affect plasma cutting quality. Cutting quality can be influenced by a number of factors. Everything starts with the proper choice of a CNC machine and a plasma source. The quality also depends on the expertise and experience of the machine operator and the setting of the plasma cutting parameters. This issue of influences on the plasma cutting quality is based on long-term experience in the field of the thermal cutting process.