bluuebunny/crossref_metadata_2025_split huggingface dataset:
When neighbors become aggressors: the local tensions behind the expulsion of Jews from Eastern Thrace in 1934
Authors: Basaranlar Burak 
Published: December 2024

Abstract
This article examines the local context that led to the expulsion of Jews from Eastern Thrace in 1934. Going beyond the conventional state-centric narratives, it unearths the local socio-economic tensions that triggered the locals to target their Jewish neighbors. It highlights three major factors that fueled already-existing nationalist sentiments in the region: some Jewish merchants’ involvement in usury, Turkish–Muslim agricultural producers’ growing indebtedness due to the devastating impact of the Great Depression, and the government’s failure to support producers with appropriate credit policies. Faced with the danger of indebtedness and dispossession, the locals in this context deemed the small Jewish community as “the easy target,” scapegoating it for their ongoing problems amid Turkey’s nationalist political climate in the 1930s.
THE LAW GOVERNING UNITED KINGDOM GOVERNMENT TORT LIABILITY IN THE ‘WAR ON TERROR’
Authors: Grušić Uglješa 
Published: December 2024

AbstractThis article discusses the United Kingdom Supreme Court judgment in Zubaydah v Foreign, Commonwealth and Development Office, which addressed the law governing the tort liability of the United Kingdom Government for its alleged complicity in the claimant's arbitrary detention and torture overseas by the Central Intelligence Agency. In holding that English law applied, the Court departed from previous case law by giving decisive weight to public law factors in its choice-of-law reasoning. This decision arguably heralds a greater role for English law in relation to tort claims brought by overseas victims of allegedly wrongful exercises of British executive authority as a mechanism for achieving executive accountability, controlling abuse of power, ensuring the rule of law and providing victims access to remedy.
Suicidality and use of psychotropic medications in patients with schizophrenia: a prospective cohort study
Authors: Strømme Maria Fagerbakke , Thue Augustsson Mina , Bartz-Johannessen Christoffer , Stautland Andrea , Mykletun Arnstein , Kroken Rune Andreas , Mehlum Lars , Kjelby Eirik , Johnsen Erik 
Published: December 2024

AbstractBackgroundThe lifetime prevalence of suicide is around 5% in patients with schizophrenia. Non-adherence to antipsychotic medication is an important risk factor, but prospective studies investigating joint effects of antipsychotic drugs, antidepressants, and benzodiazepines on suicidality are scarce. We aimed to investigate how use and non-use of psychotropic medications are associated with suicidality in schizophrenia.MethodsAn open cohort study followed all patients consecutively admitted to a psychiatric acute unit during a 10-year period with a diagnosis of schizophrenia (n = 696). Cox multiple regression analyses were conducted with use of antipsychotics, antidepressants, and benzodiazepines as time-dependent variables. Adjustments were made for age, gender, depressive mood, agitated behavior, and use of alcohol and illicit substances.ResultsA total of 32 (4.6%) suicide events were registered during follow-up. Of these, 9 (28%) were completed suicides and 23 (72%) were attempted suicides. A total of 59 (8.5%) patients were readmitted with suicidal plans during the follow-up. Compared to non-use, use of antipsychotics was associated with 70% lower risk of attempted or completed suicide (adjusted hazard ratio [AHR] = 0.30, p < 0.01, CI 0.14–0.65) and 69% reduced risk of readmission with suicidal plans (AHR = 0.31, p < 0.01, CI 0.18–0.55). Use of prescribed benzodiazepines was associated with 126% increased risk of readmission with suicidal plans (AHR = 2.26, p = 0.01, CI 1.24–4.13).ConclusionsAdherence to antipsychotic medication is strongly associated with reduced suicidal risk in schizophrenia. The use of prescribed benzodiazepines was identified as a significant risk factor for being readmitted with suicidal plans.
Stokesy ct. Foakesy b. Woakesy
Authors: Robinson Jonnie 
Published: December 2024

Abstract
Using a data set of nicknames of elite athletes compiled from the mainstream British sporting press and media, this article explores grammatical patterns in the way we create hypocoristic nicknames like Hughesie, Robbo and Macca. It outlines the purpose of nicknames and their particular role in sport, and provides an analysis of the predictable morphological and phonological rules that apply to a type of nickname categorised here as ‘transparent’. It offers some initial observations on the social distribution of particular nickname variants and on the potential for creativity and playfulness inherent in transparent nicknaming processes.
Cost-effectiveness analysis of a nonphysician-led, community-based blood pressure intervention in rural China based on CRHCP research
Authors: Li Qiaoqiao , Xu Teng , Hu Tianyang , Lou Yake 
Published: December 2024

Abstract

Background
The China Rural Hypertension Control Project (CRHCP) is a nonphysician-led community-based hypertension intervention program that has demonstrated clear benefits in improving blood pressure (BP) control and reducing the incidence of cardiovascular disease events among hypertensive patients in rural areas of China. However, it is currently unclear whether the benefits of the CRHCP outweigh its costs, and whether promoting this project in China is justifiable from a perspective of healthcare system.

Methods
We employed a Markov model to forecast the anticipated 20-year costs and effectiveness of the CRHCP trial. Cost data for this study was gathered from public records or published papers, whereas clinical data was extracted from the CRHCP trial. Our primary outcome measure was the incremental cost-effectiveness ratio, expressed in Chinese Yuan (CNY) per quality-adjusted life-year (QALY), representing the additional cost per additional QALY gained.

Results
Over a span of 20 years, the cost for a rural hypertensive individual in China who received intensive BP intervention by a nonphysician community healthcare provider would amount to 25,129 CNY, yielding an effectiveness of 8.19 QALY. In contrast, if usual care was provided, the cost would be 26,709 CNY with an effectiveness of 7.94 QALY. The CRHCP program demonstrated lower costs and greater effectiveness for rural hypertensive individuals in China.

Conclusion
Our study indicates that the implementation of the CRHCP program among rural hypertensive individuals in China resulted in increased effectiveness and reduced costs. From the perspective of Chinese healthcare system, the CRHCP program proves to be cost-saving within the current healthcare landscape.
New or repurposed: a novel classification system for the horizon scanning of innovative medicines
Authors: Fairbairn Ross , Akinbolade Sola , Coughlan Diarmuid , Ogunbayo Dapo , Meader Nick , Craig Dawn 
Published: December 2024

Abstract

Objectives
It is vital that horizon scanning organizations can capture and disseminate intelligence on new and repurposed medicines in clinical development. To our knowledge, there are no standardized classification systems to capture this intelligence. This study aims to create a novel classification system to allow new and repurposed medicines horizon scanning intelligence to be disseminated to healthcare organizations.

Methods
A multidisciplinary working group undertook literature searching and an iterative, three-stage piloting process to build consensus on a classification system. Supplementary data collection was carried out to facilitate the implementation and validation of the system on the National Institute of Health and Care Research (NIHR) Innovation Observatory (IO)‘s horizon scanning database, the Medicines Innovation Database (MInD).

Results
Our piloting process highlighted important issues such as the patency and regulatory approval status of individual medicines and how combination therapies interact with these characteristics. We created a classification system with six values (New Technology, Repurposed Technology (Off-patent/Generic), Repurposed Technology (On-patent/Branded), Repurposed Technology (Never commercialised), New + Repurposed Technology (Combinations-only), Repurposed Technology (Combinations-only)) that account for these characteristics to provide novel horizon scanning insights. We validated our system through application to over 20,000 technology records on the MInD.

Conclusions
Our system provides the opportunity to deliver concise yet informative intelligence to healthcare organizations and those studying the clinical development landscape of medicines. Inbuilt flexibility and the use of publicly available data sources ensure that it can be utilized by all, regardless of location or resource availability.
Long‐Term Capturability of Atmospheric Water on a Global Scale
Authors: Li Fang‐Fang , Lu Hou‐Liang , Wang Guang‐Qian , Qiu Jun 
Published: December 2024

AbstractGlobal warming has changed both the amount of global precipitation and the atmospheric capacity to retain water. In this paper, a novel definition of the long‐term Capturability of Atmospheric Water (CAW) based on horizontal atmospheric water transport is proposed, describing the ability of a certain area to intercept and convert the atmospheric water transported by horizontal moisture flux into local precipitation. The significant decrease of the CAW in Amazon and Congo rainforests and Inside Greenland indicates that these areas were having less precipitation with the same water vapor in the past 42 years, while in Asia (especially China), CAW is showing a large‐scale increasing trend, verifying the regional humidifying. Considering the change of both the CAW and the background atmospheric water simultaneously, their mismatch degree is also investigated. The positive mismatch in Qinghai Tibet Plateau, Greenland, and the Andes, suggests higher susceptibility to climate change, and in the areas of negative mismatch (Amazon, Maritime Continent, southeastern China, the Eastern United States, India, and Japan), a more stable precipitation response to climate change is expected. The proposed concept of CAW provides a novel perspective to analyze the precipitation response to climate change on a global scale.
A Quiet‐Day Ionospheric Electrodynamics Empirical Model in the Low and Middle Latitudes
Authors: Wang Yuhan , Ren Zhipeng , Liu Yunbo 
Published: December 2024

AbstractIn this paper, we develop a climatology model of the ionospheric electric field and potential at low and middle latitudes on quiet time, utilizing plasma drift observed from the ROCSAT‐1 satellite. The meridional/vertical and zonal E × B drifts are transformed to the electric fields using modified Apex coordinates under the real geomagnetic field model. The electric field data are adjusted to different solar levels through bilinear fitting, and organized into seasonal, longitudinal, latitudinal bins. The fully normalized associated Legendre functions are chosen as the fitting basis modes. Our model can effectively describe the latitudinal dependence of the electrodynamics parameters cover equatorward of 35° magnetic latitude. The fitted drifts hold the fundamental characteristics of the results observed prior to fitting. The model potential can well shows the typical morphological characteristics that are in great agreement with prior research findings. Furthermore, the potential variations exhibit distinct seasonal, solar flux, and UT dependence under moderate and high solar flux conditions. Within the framework of this model, the potential, electric field, and drift can be mutually converted while maintaining self‐consistency.
Identifying Three‐Dimensional Radiative Patterns Associated With Early Tropical Cyclone Intensification
Authors: Iat‐Hin Tam Frederick , Beucler Tom , Ruppert James H. 
Published: December 2024

AbstractCloud radiative feedback impacts early tropical cyclone (TC) intensification, but limitations in existing diagnostic frameworks make them unsuitable for studying asymmetric or transient radiative heating. We propose a linear Variational Encoder‐Decoder (VED) framework to learn the hidden relationship between radiative anomalies and the surface intensification of realistic simulated TCs. The uncertainty of the VED model identifies periods when radiation has more importance for intensification. A close examination of the radiative pattern extracted by the VED model from a 20‐member ensemble simulation on Typhoon Haiyan shows that longwave forcing from inner core deep convection and shallow clouds downshear contribute to intensification, with deep convection in the downshear‐left quadrant having the most impact overall on the intensification of that TC. Our work demonstrates that machine learning can aid the discovery of thermodynamic‐kinematic relationships without relying on axisymmetric or deterministic assumptions, paving the way for the objective discovery of processes leading to TC intensification in realistic conditions.
Esophageal ILC2s mediate abnormal epithelial remodeling in eosinophilic esophagitis via Areg-EGFR signaling
Authors: Lim MinYeong , Kim Taesoo , Kim Hyesung , Jang Bo Gun , Myung Jae Kyung , Kim Hye Young 
Published: December 2024

AbstractEosinophilic esophagitis (EoE) is a chronic allergic disorder characterized by eosinophilia and epithelial thickening, resulting in dysphagia. While emerging evidence implicates increased frequencies of group 2 innate lymphoid cells (ILC2s) and increased interleukin (IL)-33 expression in EoE pathogenesis, the precise mechanisms remain unclear. In this study, we investigated the role of ILC2s in EoE pathogenesis. We observed an abundance of KLRG1+ ILC2s in the esophagi of healthy mice, with their numbers significantly increasing in murine EoE models and humans. Using a murine EoE model, we demonstrated the recapitulation of EoE-associated features, including basal-cell hyperproliferation, epithelial thickening, and eosinophilia. Notably, these characteristics are absent in ILC-deficient mice, whereas mice lacking IL-5 or eosinophils display epithelial defects, highlighting the pivotal role of ILC2s in EoE pathogenesis. Further investigations revealed increased amphiregulin (Areg) production by esophageal ILC2s in mice. The administration of Areg induced epithelial defects similar to those observed in EoE. Mechanistic studies using human esophageal cell lines revealed Areg-induced phosphorylation of epidermal growth factor receptor (EGFR). Significatntly, treatment with anti-Areg agents and EGFR inhibitors effectively attenuated EoE development, highlighting the therapeutic potential of targeting the Areg-EGFR axis.
Enhanced resolution of optical genome mapping utilizing telomere-to-telomere reference in genetic disorders
Authors: Banu Sofia , MK Kanakavalli , George Joel Kiran , Siby Elizabeth , Bhagat Rakeshpal , MS Sreelekshmi , Patil Siddaramappa J. , Phadke Shubha R. , Sowpati Divya Tej , Tallapaka Karthik Bharadwaj 
Published: December 2024

AbstractReference genomes serve as a baseline criterion for comparison of personal genomes to deduce clinical variants. The widely used reference genome, GRCh38, contains stretches of gaps and unresolved bases particularly in complex regions which could obscure variant discovery. In contrast, the gapless telomere-to-telomere CHM13 (T2T-CHM13) reference genome can be used to assess difficult regions of the genome. Optical genome mapping (OGM), an imaging technique for structural variation identification has improved resolution compared to traditional cytogenetic methods. Our study showcases the utility of the T2T-CHM13 reference genome for enhanced structural variant (SV) detection in complex regions. We illustrate this through two clinical cases, where improved alignment with T2T-CHM13 led to significantly higher confidence scores for critical SVs. We demonstrate improved clinical diagnostic outcomes with the updated T2T-CHM13 reference and advocate its adoption.
The assessment and aetiology of drug-induced ischaemic priapism
Authors: Moodley Divyen , Badenhorst Anja , Choonara Yahya , Adam Ahmed 
Published: December 2024

AbstractIschaemic priapism is a urological emergency characterised by a prolonged, painful erection unrelated to sexual stimulation. While several aetiological factors contribute to this condition, the pharmacological causes have gained significant attention in recent years. This narrative review aims to comprehensively assess ischaemic priapism, specifically focusing on its pharmacological aetiology. We propose an approach and assessment strategy to the numerous factors associated with pharmacologically induced ischaemic priapism. By enhancing our understanding of the pharmacological causes of this condition, healthcare professionals can improve patient management and reduce the long-term complications associated with ischaemic priapism.
Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance
Authors: Ambroziak Wojciech , Nencini Sara , Pohle Jörg , Zuza Kristina , Pino Gabriela , Lundh Sofia , Araujo-Sousa Carolina , Goetz Larissa I. L. , Schrenk-Siemens Katrin , Manoj Gokul , Herrera Mildred A. , Acuna Claudio , Siemens Jan 
Published: December 2024

Abstract
Heat acclimation is an adaptive process that improves physiological performance and supports survival in the face of increasing environmental temperatures, but the underlying mechanisms are not well understood. Here we identified a discrete group of neurons in the mouse hypothalamic preoptic area (POA) that rheostatically increase their activity over the course of heat acclimation, a property required for mice to become heat tolerant. In non-acclimated mice, peripheral thermoafferent pathways via the parabrachial nucleus activate POA neurons and mediate acute heat-defense mechanisms. However, long-term heat exposure promotes the POA neurons to gain intrinsically warm-sensitive activity, independent of thermoafferent parabrachial input. This newly gained cell-autonomous warm sensitivity is required to recruit peripheral heat tolerance mechanisms in acclimated animals. This pacemaker-like, warm-sensitive activity is driven by a combination of increased sodium leak current and enhanced utilization of the NaV1.3 ion channel. We propose that this salient neuronal plasticity mechanism adaptively drives acclimation to promote heat tolerance.
An interpretable RNA foundation model for exploring functional RNA motifs in plants
Authors: Yu Haopeng , Yang Heng , Sun Wenqing , Yan Zongyun , Yang Xiaofei , Zhang Huakun , Ding Yiliang , Li Ke 
Published: December 2024

AbstractThe complex ‘language’ of plant RNA encodes a vast array of biological regulatory elements that orchestrate crucial aspects of plant growth, development and adaptation to environmental stresses. Recent advancements in foundation models (FMs) have demonstrated their unprecedented potential to decipher complex ‘language’ in biology. In this study, we introduced PlantRNA-FM, a high-performance and interpretable RNA FM specifically designed for plants. PlantRNA-FM was pretrained on an extensive dataset, integrating RNA sequences and RNA structure information from 1,124 distinct plant species. PlantRNA-FM exhibits superior performance in plant-specific downstream tasks. PlantRNA-FM achieves an F1 score of 0.974 for genic region annotation, whereas the current best-performing model achieves 0.639. Our PlantRNA-FM is empowered by our interpretable framework that facilitates the identification of biologically functional RNA sequence and structure motifs, including both RNA secondary and tertiary structure motifs across transcriptomes. Through experimental validations, we revealed translation-associated RNA motifs in plants. Our PlantRNA-FM also highlighted the importance of the position information of these functional RNA motifs in genic regions. Taken together, our PlantRNA-FM facilitates the exploration of functional RNA motifs across the complexity of transcriptomes, empowering plant scientists with capabilities for programming RNA codes in plants.
Pattern speed evolution of barred galaxies in TNG50
Authors: Semczuk Marcin , Dehnen Walter , Schönrich Ralph , Athanassoula E. 
Published: December 2024

Context. Galactic bars are found in the majority of disc galaxies. They rotate nearly rigidly with an angular frequency called pattern speed. In idealised simulations, the bar pattern speed generally decreases with time due to dynamical friction exerted by the dark-matter halo, while cold gas can reduce or even reverse this trend.
Aims. We want to understand how different galaxy properties affect the evolution of the bar pattern speed in more realistic situations, including ongoing star formation, mass infall, active galactic nucleus (AGN) feedback, and galaxy interactions.
Methods. We traced the pattern-speed evolution of simulated bars in the TNG50-1 cosmological simulations.
Results. Simulated bars with an initially high pattern speed and a subsequent rapid slowdown are more likely found in more massive galaxies. Lower mass galaxies, on the other hand, preferentially host bars that start at relatively low pattern speeds and retain the same value until the end of the simulation. More massive simulated barred galaxies are also more affected by the AGN-feedback model, which very efficiently removes the cold gas that could have prevented the slowdown.
Conclusions. We find that bars grow and strengthen with slowdown, in agreement with higher resolution simulations. We find that strong correlations between the bar slowdown rate and galaxy mass weaken considerably when we use dimensionless measures to quantify the slowdown. In TNG50, the AGN-feedback prescription amplifies the mass dependence. Turned around, this provides an interesting statistic to constrain sub-grid physics by bar growth and slowdown.
Mutual neutralization of C60+ and C60− ions
Authors: Gatchell Michael , Paul Raka , Ji MingChao , Rosén Stefan , Thomas Richard D. , Cederquist Henrik , Schmidt Henning T. , Larson Åsa , Zettergren Henning 
Published: December 2024

Context. Mutual neutralization (MN) between cations and anions plays an important role in determining the charge balance in certain astrophysical environments. However, empirical data for such reactions involving complex molecular species have been lacking due to challenges in performing experimental studies, leaving the astronomical community to rely on decades-old models with large uncertainties for describing these processes in the interstellar medium.
Aims. Our aim is to investigate the MN reaction C60+ + C60− → C60* + C60 for collisions at interstellar-like conditions.
Methods. We studied the MN reaction between C60+ and C60− at collision energies of 100 meV using the Double ElectroStatic Ion Ring ExpEriment (DESIREE) and its merged beam capabilities. To aid in the interpretation of the experimental results, semiclassical modeling based on the Landau-Zener approach was performed for the studied reaction.
Results. We experimentally identified a narrow range of kinetic energies for the neutral reaction products. Modeling was used to calculate the quantum state-selective reaction probabilities, absolute cross sections, and rate coefficients of these MN reactions, using the experimental results as a benchmark. We compared the MN cross sections with model results for electron attachment to C60 and electron recombination with C60+.
Conclusions. Our results show that it is crucial to take mutual polarization effects, the finite sizes, and the final quantum states of both molecular ions into account in order to obtain reliable predictions of MN rates expected to strongly influence the charge balance and chemistry in environments such as dense molecular clouds.