bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elderly Patients with Advanced Head and Neck Carcinoma: Does Aggressive Treatment Result in Better Outcomes?
Authors: Jang Isabelle J. H. , Skanthakumar Thakshayeni , Tan Hiang Khoon , Tan Ngian Chye , Soo Khee Chee , Iyer N. Gopalakrishna 
Published: December 2018

ObjectiveThere are no well‐defined treatment recommendations for elderly patients with advanced head and neck squamous cell carcinoma. This study aimed to investigate whether aggressive treatment among the elderly translated into better survival outcomes.Study DesignRetrospective cohort study.SettingSingle tertiary institution.Subjects and MethodsElderly patients (≥60 years) with advanced‐stage head and neck squamous cell carcinoma (stage III and IV) treated between January 1991 and May 2014 were reviewed. According to current National Comprehensive Cancer Network guidelines, they were classified to have received standard or substandard treatment. Overall survival (OS), locoregional recurrence‐free survival, and distant recurrence‐free survival were evaluated.ResultsA total of 355 patients were treated curatively: 194 with up‐front surgery and 161 with radiotherapy or concurrent chemotherapy and radiotherapy. Median OS was higher among patients who received standard treatment (42.0 vs 16.0 months, P <. 001). On multivariate analysis, standard treatment showed superior OS (P <. 001). Use of substandard treatment showed a hazard ratio of 2.09 (95% CI, 1.59‐2.74) for poorer OS.ConclusionAggressive standard treatment protocols should be advocated for elderly patients, where comorbidities permit, as they confer better outcomes.
Safety and efficacy of combined ruxolitinib and decitabine in accelerated and blast-phase myeloproliferative neoplasms
Authors: Rampal Raajit K. , Mascarenhas John O. , Kosiorek Heidi E. , Price Leah , Berenzon Dmitriy , Hexner Elizabeth , Abboud Camille N. , Kremyanskaya Marina , Weinberg Rona Singer , Salama Mohamed E. , Menghrajani Kamal , Najfeld Vesna , Sandy Lonette , Heaney Mark L. , Levine Ross L. , Mesa Ruben A. , Dueck Amylou C. , Goldberg Judith D. , Hoffman Ronald 
Published: December 2018

Abstract
Myeloproliferative neoplasms (MPN), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, have a propensity to evolve into accelerated and blast-phase disease (MPN-AP/BP), carrying a dismal prognosis. Conventional antileukemia therapy has limited efficacy in this setting. Thus, MPN-AP/BP is an urgent unmet clinical need. Modest responses to hypomethylating agents and single-agent ruxolitinib have been reported. More recently, combination of ruxolitinib and decitabine has demonstrated synergistic in vitro activity in human and murine systems. These observations led us to conduct a phase 1 study to explore the safety of combined decitabine and dose-escalated ruxolitinib in patients with MPN-AP/BP. A total of 21 patients were accrued to this multicenter study. Ruxolitinib was administered at doses of 10, 15, 25, or 50 mg twice daily in combination with decitabine (20 mg/m2 per day for 5 days) in 28-day cycles. The maximum tolerated dose was not reached. The most common reasons for study discontinuation were toxicity/adverse events (37%) and disease progression (21%). Fourteen patients died during study treatment period or follow-up. The median overall survival for patients on study was 7.9 months (95% confidence interval, 4.1-not reached). Among evaluable patients, the overall response rate by protocol-defined criteria (complete remission with incomplete count recovery + partial remission) was 9/17 (53%) and by intention-to-treat analysis was 9/21 (42.9%). The combination of decitabine and ruxolitinib was generally well tolerated by patients with MPN-AP/BP and demonstrates potentially promising clinical activity. A phase 2 trial evaluating the efficacy of this combination regimen is ongoing within the Myeloproliferative Disorder Research Consortium.
Advanced forms of MPNs are accompanied by chromosomal abnormalities that lead to dysregulation of TP53
Authors: Marcellino Bridget K. , Hoffman Ronald , Tripodi Joseph , Lu Min , Kosiorek Heidi , Mascarenhas John , Rampal Raajit K. , Dueck Amylou , Najfeld Vesna 
Published: December 2018

Abstract
The Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and the prefibrotic form of primary myelofibrosis (PMF), frequently progress to more overt forms of MF and a type of acute leukemia termed MPN-accelerated phase/blast phase (MPN-AP/BP). Recent evidence indicates that dysregulation of the tumor suppressor tumor protein p53 (TP53) commonly occurs in the MPNs. The proteins MDM2 and MDM4 alter the cellular levels of TP53. We investigated in 1,294 patients whether abnormalities involving chromosomes 1 and 12, which harbor the genes for MDM4 and MDM2, respectively, and chromosome 17, where the gene for TP53 is located, are associated with MPN disease progression. Gain of 1q occurred not only in individuals with MPN-BP but also in patients with PV and ET, who, with further follow-up, eventually evolve to either MF and/or MPN-BP. These gains of 1q were most prevalent in patients with a history of PV and those who possessed the JAK2V617F driver mutation. The gains of 1q were accompanied by increased transcript levels of MDM4. In contrast, 12q chromosomal abnormalities were exclusively detected in patients who presented with MF or MPN-BP, but were not accompanied by further increases in MDM2/MDM4 transcript levels. Furthermore, all patients with a loss of 17p13, which leads to a deletion of TP53, had either MF or MPN-AP/BP. These findings suggest that gain of 1q, as well as deletions of 17p, are associated with perturbations of the TP53 pathway, which contribute to MPN disease progression.
Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
Authors:   on behalf of the GLIMP Study Group, Gramegna Andrea , Sotgiu Giovanni , Di Pasquale Marta , Radovanovic Dejan , Terraneo Silvia , Reyes Luis F. , Vendrell Ester , Neves Joao , Menzella Francesco , Blasi Francesco , Aliberti Stefano , Restrepo Marcos I. 
Published: December 2018

Abstract

Background
Empirical antibiotic coverage for atypical pathogens in community-acquired pneumonia (CAP) has long been debated, mainly because of a lack of epidemiological data. We aimed to assess both testing for atypical pathogens and their prevalence in hospitalized patients with CAP worldwide, especially in relation with disease severity.

Methods
A secondary analysis of the GLIMP database, an international, multicentre, point-prevalence study of adult patients admitted for CAP in 222 hospitals across 6 continents in 2015, was performed. The study evaluated frequency of testing for atypical pathogens, including L. pneumophila, M. pneumoniae, C. pneumoniae, and their prevalence. Risk factors for testing and prevalence for atypical pathogens were assessed through univariate analysis.

Results
Among 3702 CAP patients 1250 (33.8%) underwent at least one test for atypical pathogens. Testing varies greatly among countries and its frequency was higher in Europe than elsewhere (46.0% vs. 12.7%, respectively, p < 0.0001). Detection of L. pneumophila urinary antigen was the most common test performed worldwide (32.0%). Patients with severe CAP were less likely to be tested for both atypical pathogens considered together (30.5% vs. 35.0%, p = 0.009) and specifically for legionellosis (28.3% vs. 33.5%, p = 0.003) than the rest of the population. Similarly, L. pneumophila testing was lower in ICU patients. At least one atypical pathogen was isolated in 62 patients (4.7%), including M. pneumoniae (26/251 patients, 10.3%), L. pneumophila (30/1186 patients, 2.5%), and C. pneumoniae (8/228 patients, 3.5%). Patients with CAP due to atypical pathogens were significantly younger, showed less cardiovascular, renal, and metabolic comorbidities in comparison to adult patients hospitalized due to non-atypical pathogen CAP.

Conclusions
Testing for atypical pathogens in patients admitted for CAP in poorly standardized in real life and does not mirror atypical prevalence in different settings. Further evidence on the impact of atypical pathogens, expecially in the low-income countries, is needed to guidelines implementation.
Synchrotron tts-µXRD identification of secondary phases in ancient ceramics
Authors: Maritan Lara , Casas Lluís , Crespi Anna , Gravagna Elisa , Rius Jordi , Vallcorba Oriol , Usai Donatella 
Published: December 2018

Abstract
The study of the alteration process, and in particular of secondary phases precipitated in pottery after its production, can constrain the post-depositional environments or the type of use of the pottery. Detailed study of secondary phases can be done using different approaches, based on microscopic, microstructural and microchemical analyses, as well as mineralogical methods. In the present study are reported the results of the application of punctual mineralogical analysis by synchrotron through-the-substrate microdiffraction (tts-μXRD) to analyse secondary phases precipitated in ancient pottery (Bronze Age pottery form Frattesina in Italy and Mesolithic pottery form Al Khiday in Sudan). Although the chemical composition of these secondary phases in many cases almost matches with the stoichiometric composition of a known mineral, only some of them were actually true mineral phases (i.e. with crystallinity and therefore showing diffraction peaks), while others were amorphous. Some phases, the occurrence of which was previously attested only on the basis of their chemical composition (determined by scanning electron microscope or the electron microprobe analysis), were univocally identified as true vivianite (Fe3(PO4)2·8H2O) and crandallite (CaAl3(PO4)2(OH)5·H2O) minerals. Part of the phases detected in studied pottery, the chemical composition of which was consistent with specific mineral phases, were instead amorphous. The synchrotron through-the-substrate microdiffraction (tts-μXRD), therefore, represents a valid method for properly determine the mineralogical nature of secondary phases in pottery, as well as other small-sized and rare mineral phases occurring in polycrystalline materials of archaeological interest, such as pottery, mortars, painting and glassy materials.
Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing
Authors: Xue Si-Liang , Liu Kai , Parolini Ornella , Wang Yue , Deng Li , Huang Yong-Can 
Published: December 2018

Abstract

Background
The lower third of the nose is one of the most important cosmetic units of the face, and its reconstructive techniques remain a big challenge. As an alternative approach to repair or regenerate the nasal tissue, the biomaterial-based strategy has been extensively investigated. The aim of this study is to determine the safety and efficacy of human acellular amniotic membrane (HAAM) to repair the full-thickness defects in the lower third of the nose in humans.

Methods
In this study, 180 patients who underwent excision of skin lesions of the lower third of the nose from 2012 to 2016 were included; of the patients, 92 received HAAM and Vaseline gauze treatments, and the other 88 patients received Vaseline gauze treatment only. The haemostasis time and the duration of operation were recorded during surgery; after surgery, the time to pain disappearance, scab formation and wound healing, and the wound healing rate were measured.

Results
Immediately after the HAAM implantation, a reduction of the haemostasis time and an accelerated disappearance of pain were observed. Compared with the control group, the formation and detachment of scab in patients who received the HAAM implantation were notably accelerated, postoperatively. When the diameter of the lesion exceeded 5 mm, the HAAM implantation was found to enhance the wound healing, although this enhancement was not seen when the diameter was less than 5 mm. Additionally, the HAAM implantation significantly reduced bleeding, wound infection and scar formation, postoperatively.

Conclusions
HAAM-assisted healing is a promising therapy for lower third nasal reconstruction leading to rapid wound healing and fewer complications and thus has considerable potential for extensive clinical application in repairing skin wounds.

Trial registration
ChiCTR1800017618, retrospectively registered on July 08, 2018.
Analisis Pengaruh Penggunaan Teks di Gambar Iklan terhadap Jangkauan dan Interaksi Konsumen
Authors: Fikri Khairul 
Published: December 2018

Iklan merupakan salah satu alternatif untuk mempromosikan produk atau jasa yang ingin dijual oleh suatu perusahaan maupun individu. Situs jejaring sosial Facebook.com sebagai salah satu penyedia layanan untuk mengiklankan produk atau jasa dengan bentuk hasil berupa jangkauan dan interaksi. Namun masalah yang sering muncul terjadi ketika pengiklan membuat iklan dengan kombinasi teks pada gambar yang tidak benar, sehingga membuat jangkauan iklan kecil dan konsumen kurang berinteraksi dengan iklan tersebut. Percobaan dilakukan menggunakan empat sampel iklan (kombinasi teks pada gambar) yaitu kombinasi rendah, kombinasi sedikit, kombinasi sedang dan kombinasi tinggi. Selanjutnya dilakukan perangkingan menggunakan metode Simple Additive Weighting (SAW). Hasil penelitian menunjukkan bahwa iklan dengan bentuk kombinasi rendah memiliki hasil jangkauan dan interaksi konsumen yang lebih besar dibandingkan iklan dengan bentuk kombinasi yang lainnya. Hal tersebut dapat dilihat dari hasil perangkingan menggunakan metode SAW dengan nilai paling tinggi dimiliki oleh kombinasi rendah, sebesar 0,6985.Kata-kata kunci: Facebook, Iklan Gambar, Interaksi Konsumen, Simple Additive Weighting, Teks. Advertising is one alternative to promote products or services that want to be sold by a company or individual. Social networking site Facebook.com as one of the service providers to advertise products or services with the results of the outreach and interaction. But the problem that often arises occurs when an advertiser creates an ad with a combination of text on an incorrect image, thereby making the reach of a small ad and consumers less interacting with the ad. The experiments were conducted using four ad samples (combination of text on images) that were low combinations, slight combinations, medium combination and high combination. Furthermore, ranking is done using Simple Additive Weighting (SAW) method. The results show that ads with low-combination forms have greater reach and costumer interaction results than ads with other combinations of forms. It can be seen from the ranking results using SAW method with the highest value is owned by a low combination, amounting to 0.6985.Keywords: Facebook, Image Ads, Consumer Interaction, Simple Additive Weighting, Text.
Fenomena Bergabungnya Anak Muda Jakarta Ke Dalam Organisasi Sinergi Muda Secara Suka Rela
Authors: Adiarsi Gracia Rachmi , Silsa Helen 
Published: December 2018

Bergabung ke dalam organisasi sebagai seorang relawan menjadi fenomena unik di kalangan anak muda, mengingat, seorang relawan harus rela untuk mengorbankan materi serta energinya demi kepentingan organisasi. Penelitian ini bertujuan untuk mengungkap alasan dari ketertarikan anak muda untuk bergabung sebagai relawan di organisasi Sinergi Muda. Teori yang digunakan ialah Theory of Needs dari David McClelland dan konsep sharing. Metode yang digunakan adalah metode penelitian kualitatif dengan menggunakan empat narasumber untuk memperoleh data primer dan data-data terkait untuk memperoleh data sekunder. Hasil penelitian menggambarkan bahwa anak muda yang bergabung sebagai relawan di organisasi Sinergi Muda bermotif kebutuhan akan pengakuan diri yang diperoleh melalui aktivitas sharing di media sosial.Kata kunci: organisasi, relawan, pengakuan diri, sharingJoining into the organization as a volunteer becomes a unique phenomenon among young people, remembering, a volunteer must be willing to sacrifice his material and energy for the sake of the organization. This study aims to reveal the reasons for the interest of young people to join as volunteers at the Sinergi Muda organization. The theory used is David McClelland's Theory of Needs and the concept of sharing. The method used is a qualitative research method by interviewing four informants to obtain primary data and related data to obtain secondary data. The result shows that young people who join as volunteers in the Sinergi Muda organization are motivated by the need for self-recognition obtained through sharing activities on social media.Keywords: Organization, volunteer, self recognition, sharing
Awareness and practices of menstrual hygiene among females of reproductive age in rural Puducherry – a mixed method study
Authors: Chandar Deepika , Vaishnavi Yamini , Priyan Shanthosh , S Ganesh Kumar 
Published: December 2018

Abstract

Background
Menstruation is a physiological process. Unfortunately, there is substantial lacuna in knowledge related to menstrual hygiene among females.

Objectives
To assess the awareness and prevailing practices of menstrual hygiene, prevalence of symptoms related to genito-urinary tract infection, and the factors influencing menstrual hygiene practices, among women of reproductive age in rural Puducherry.

Methodology
The study was conducted in March 2017 in rural Puducherry adopting a mixed-methods approach. A pre-tested semi-structured questionnaire was used for a quantitative survey among 357 women of reproductive age. Qualitative data was collected through focused group discussions (FGDs).

Results
The mean age of the participants was 28.25 + 9.25 years. Thirty-three percent of the respondents had menstrual knowledge prior to menarche. A total of 90.8% were aware that menstruation is a physiological process. The majority of respondents 94.1%, used sanitary napkins as absorbents during menstruation and 60.7% of them changed it 3 times a day. Regarding the method of disposal, 47.6% participants threw it into the routine waste and 43.8% burnt it after use. Among 8.9% of cloth users 62.5% used a new cloth for each cycle and 37.5% of respondents washed and reused the cloth. Satisfactory cleaning of external genitalia was practised by 62.2%. Only 11.2% respondents had symptoms related to genito-urinary tract infection. From FGDs it was observed that the several socio-cultural factors and taboos restrict them from practising safe menstrual hygiene practices.

Conclusion
Our study has revealed that most of the females are still unaware of menstrual hygienic practices which suggest the need for appropriate health intervention measures to be implemented for their well-being.
Cranial Electrical Stimulation in Fitness with Weightlifting Tools
Authors: Čupriks Leonīds , Vimbsons Viestards , Čuprika Aleksandra , Rudzītis Andris 
Published: December 2018

Abstract
Sport trainings are based on two essential components: the preparatory process and the athlete’s level of training as the result of the training process. The most important task of the coach is to find the most efficient way how to prepare an athlete so that he would achieve the highest capacity and would be able to implement it. Application of cranial electrical stimulation in sport is not fully explored. The aim of the study was to determine the influence of cranial electrical stimulation on the strength parameter indicators of fitness athletes who use weightlifting tools. In the study participated 10 men (representatives of fitness sport, of Latvian Academy of Sport Education, who use weightlifting tools in the training process). The age of these athletes was 21±3 years. The average weight of the athletes was 76±3.2kg and the average height was 156±15.5cm. An exercise set “lifting a weight bar to the chest” was developed. A 10 minute session of cranial electrical stimulation was applied. During the test a weightlifting bar of the company “Eleiko” was used and FiTRO Dyne Premium cable was attached on one end of the bar which was connected to a computer system and registered the data obtained during the control exercise performance. During the experiment the results obtained during two tries of control exercise performance were compared, which are the difference between the average strength parameters and the difference between the maximum strength parameters before the application of cranial electrical stimulation (hereinafter – CES), performing the first three repetitions, comparing them to the last three repetitions performed after the application of the stimulation. After cranial electrical stimulation the maximum strength parameters improved by 533.23±11.09N (α<0.05). Fitness sport representatives and coaches, in order to improve the level of training of their student, must pay attention to the application of CES in the training process with weightlifting tools.
Family Influence on Sport Activity Patterns During Early Adolescence – A Comparative Approach
Authors: Piech Krzysztof , Carlson Rolf , Grants Juris , Cherenkov Dmitriy , Gatatulin Alexey , Smaliakou Dzmitry , Lindberg Ulf 
Published: December 2018

Abstract
The aim of research is to examine and describe young individuals who participate in extended sport education program. The main focus concerns family influences on the development of the investigated youngsters’ sportive patterns. Data were collected through online and paper (whenever appropriate) questionnaires (elite sport training in secondary higher education – models of success in sport with pupils from a selection of sport schools in respective countries). Coaches from sports schools representing all participating countries (Poland, Sweden, Latvia, Russia and Belarus) were interviewed. The results indicate that the influence of parents and physical education teachers on the decision to join a sport club and to continue sport career is rather low. Main reasons behind joining a sport club are: the desire to become an athlete, sport idols, and the subjects’ own will. Staying in a sport club and pursuing a career is also determined by previous achievements in the field and good coaches. The parents’ past engagement in psychical activities was not systematic. The subjects consider local sport facilities and a number of accessible sport clubs and sports coaches to be of high importance at the early stage of their engagement in sport.
Photodynamic therapy and photothermal therapy for the treatment of peritoneal metastasis: a systematic review
Authors: Pinto Amandine , Pocard Marc 
Published: December 2018

AbstractBackgroundThe aim of this review was to analyze preclinical studies and clinical trials evaluating photodynamic therapy (PDT), and photothermal therapy (PTT) in peritoneal metastasis (PM) treatment.ContentSystematic review according PRISMA guidelines. Electronic searches using PubMed and Clinical Trials.SummaryA total of 19 preclinical studies analyzing PDT in PM treatment were included. Each new generations of photosensitizers (PS) permitted to improve tumoral targeting. Phase III preclinical studies showed an important tumoral biodistribution (ratio 9.6 vs normal tissue) and significant survival advantage (35.5 vs 52.5 days for cytoreductive surgery vs cytoreductive surgery+PDT, p<0.005). Height clinical trials showed important side effects (capillary leak syndrome and bowel perforation), mainly explained by low tumor-selectivity of the PS used (first generation mainly).Peritoneal mesothelioma apparition with carbon nanotubes first limited the development of PTT. But gold nanoparticles, with a good tolerance, permitted a limitation of tumoral growth (reduction of bioluminescence to 37 % 20 days after PTT), and survival benefit (35, 32, and 26 days for PTT with cisplatine, PTT alone and laser alone, respectively).OutlookRecent improvement in tumor-selectivity and light delivery systems is promising but further development would be necessary before PDT and PTT routinely applied for peritoneal carcinomatosis.