bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Aqueous Processed Photosensitive Bilayer van der Waals Thin Film for Flexible Neuromorphic Vision
Authors: Xu Min , Wang Shao‐Hua , Liu Bin , Dong Xue‐Mei , Yu Meng‐Na , Wang Kai‐Li , Zhu Duo‐Yi , Li Xiu‐Juan , Sun Hong‐Chao , Zhang Fa , Wu Ji‐Cai , Liu Ju‐Qing , Li Yin‐Xiang , Huang Wei 
Published: December 2024

AbstractPrinting colloidal ink of semiconductor nanocrystals, particularly 2D nanosheets, facilitates the generation of van der Waal's thin films (vdWTFs) with inherent flexibility and optoelectronic properties, ideal for wearable intelligence devices, such as bionic vision. Several intricate strategies, such as mechanical/electrochemical exfoliation and pulsed laser/chemical vapor, have been devised for producing solvent‐dispersed nanosheets and corresponding vdWTFs; achieving efficient preparation via more environmentally friendly processes remains a challenge. Here, an ecofriendly aqueous approach for crafting vdWTF, relying on a gentle self‐assembly C8‐BTBT nanosheet aqueous ink, is demonstrated. The resulting vdWTF features a bilayer heterostructure, wherein a crystalline C8‐BTBT nanosheet layer is staggeringly stacked atop a graphene oxide (GO) film. This configuration allows the sliding of the staggered 2D nanosheets, accommodating local tension and compression, thereby averting film breakage and ensuring desirable flexibility. Further, by harnessing the natural photosensitivity of C8‐BTBT and the charge‐trapping capabilities of GO component, the heterostructured bilayer vdWTFs confer exceptional photoperception and intrinsic persistent photoconductivity effects upon their flexible planar devices. These attributes enable the emulation of bio‐visual behaviors such as short/long‐term memory, light adaptation, reinforcement learning, and image recognition.
Chronic Stress‐Induced and Tumor Derived SP1+ Exosomes Polarizing IL‐1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer
Authors: Zhang Leyi , Pan Jun , Wang Meijun , Yang Jini , Zhu Sangsang , Li Lili , Hu Xiaoxiao , Wang Zhen , Pang Liwei , Li Peng , Jia Fang , Ren Guohong , Zhang Yi , Xu Danying , Qiu Fuming , Huang Jian 
Published: December 2024

AbstractChronic stress can significantly promote breast cancer progression. When exposed to chronic stress, exosomes released from neural and neuroendocrine cells in the central nervous system are enhanced and modified. However, whether tumor‐derived exosomes (TDEs) are influenced by chronic stress and participate in chronic stress‐mediated distant metastasis remains unclear. Here, it is shown that chronic stress remarkably facilitates the secretion of TDEs and modifies the contents of exosomes by activating the adrenergic β receptor in 4T1 tumor‐bearing mice. Exosomes injection and blockade experiments indicate that exosomes play a crucial role in chronic stress‐mediated lung metastasis of breast cancer. Chronic stress‐induced TDEs are internalized by pulmonary neutrophils and strengthen neutrophil recruitment via the CXCL2 autocrine. In addition, the level of SP1 in TDEs increases, which favors the secretion of IL‐1β by neutrophils through the activation of the TLR4‐NFκβ pathway, ultimately aggravating lung metastasis of breast cancer. Collectively, this study provides a novel mechanism by which neutrophils within a pre‐metastatic niche acquire their inflamed phenotype and establishes an important link among neuroendocrine changes, exosomes, immunity, and metastasis.
The Arabidopsis RING‐Type E3 Ligase TEAR4 Controls Seed Germination by Targeting RGA for Degradation
Authors: Yu Hao , Wang Yutao , Wang Yi , Deng Xing Wang , Qin Genji 
Published: December 2024

AbstractLight and DELLA proteins are central factors controlling seed germination which is critical for seed plant survival and agricultural production. However, the mechanisms underlying DELLA degradation under different light conditions during seed germination remain to be clarified. Here, it is reported that TIE1‐ASSOCIATED RING‐TYPE E3 LIGASE4 (TEAR4) and other TEARs redundantly promote DELLA degradation to positively regulate seed germination in Arabidopsis. The tear1/2/3/4/5/6 sextuple mutant displayed delayed seed germination under the white or PhyB‐dependent light condition, and nearly no seed germination under the PhyA‐dependent light condition. The DELLA protein REPRESSOR OF ga1‐3 (RGA) accumulated in tear1/2/3/4/5/6, and disruption of RGA and GA‐INSENSITIVE (GAI) in tear1/2/3/4/5/6 rescued defective seed germination. Far‐red (FR) light rapidly induced TEARs, and TEAR4 is shown to act as an E3 ligase. It is showed that both GA‐dependent and TEAR‐mediated DELLA degradation pathways are indispensable for PhyA‐dependent germination. It is found that TEAR homologs PpTEAR1 and PpTEAR2 from the moss Physcomitrium patens interacted with Arabidopsis DELLAs to promote their degradation, and overexpression of PpTEAR1 or PpTEAR2 completely rescued defective PhyA‐dependent seed germination in phya‐211. This findings demonstrate that TEARs act as critical players in fine‐tuning seed germination, and TEAR‐mediated DELLA degradation might be an ancient pathway conserved in plant kingdom.
Prognostic Value of Skull Base Foramen Invasion Subclassification in T Category Modification and Induction Chemotherapy Management for Nasopharyngeal Carcinoma: Post‐Hoc Analysis of a Dual‐Center Retrospective Cohort Study
Authors: Zhu Siyu , Li Shuqi , Cao Di , Luo Chao , Liang Zhiying , Liang Shaobo , Zhang Guoyi , Zhao Qin , Ruan Guangying , Liu Lizhi , Fu Gui , Li Haojiang 
Published: December 2024

AbstractSkull base foramen invasion (SBFI) indicates poor prognosis in nasopharyngeal carcinoma (NPC). However, only a few studies systematically assessed the role of SBFIin staging and treatment of NPC. To investigate the prognostic value of SBFI in NPC, a total of 1,752 patients with nonmetastatic NPC from two hospitals (1,320 and 432) between January 2010 and March 2014 are enrolled. The primary endpoint is overall survival (OS). Heatmap/cluster and network analyses are used to provide subclassification indication. Univariate and multivariate analyses with Kaplan–Meier method are performed to compare survival outcomes. SBFIs are classified into slight (only foramen lacerum and/or pterygopalatine fossa invasion) and severe (other SBFIs). The severe SBFI is an unfavorable prognosticator for OS in both the entire cohort and the T3 group. OS is similar between T3 with severe SBFI and T4 patients. Reclassifying T3 with severe SBFI as the T4 category yields an improved T category discrimination. Additionally, patients in the severe SBFI group gain significant survival benefits from induction chemotherapy ((IC). Therefore, T3 NPC with severe SBFI is an independent negative predictor for OS and is classified into the T4 category. T category adjustment enables better prognostic stratification. Severe SBFI benefits from IC in long‐term OS.
OMP38 of Carbapenem‐Resistant Acinetobacter Baumannii‐Mediated mtDNA Release Activates the cGAS‐STING Signaling to Induce Inflammatory Response
Authors: Yang Yang , Zeng Yuanyuan , Zhu Jianjie , Li Jianjun , Gu Lei , Wei Lin , Liu Zeyi , Huang Jian‐an 
Published: December 2024

AbstractCarbapenem‐resistant Acinetobacter baumannii (CRAB) has become a major threat in the treatment of bacterial infection, and immunotherapy in a non‐antibiotic‐dependent manner is an effective way to overcome CRAB infection. However, the role of the innate immune response in CRAB infection is poorly understood. Here, it is reported that CRAB infection induced a cytosolic DNA‐sensing signaling pathway and significant IFN‐β production in mice post‐CRAB infection. The knockout of STING reduced bacterial burden, the production of inflammatory cytokines, and lung injury in mice post CRAB infection. The cytosolic DNA sensor cyclic GMP‐AMP synthase (cGAS) and the adaptor protein stimulator of interferon genes (STING) are required for CRAB‐induced IFN‐β expression in macrophages. Intriguingly, CRAB utilized outer membrane vesicles (OMVs) to transport outer membrane protein 38 (OMP38) into mitochondria, triggering mitochondrial DNA (mtDNA) release into the cytosol through the mitochondrial permeability transition pore (mPTP) and activating the cGAS‐STING signaling. Finally, epigallocatechin gallate (EGCG) is demonstrated to block the activation of the cGAS‐STING pathway and ameliorate CRAB‐induced excessive inflammatory response. These results demonstrated that the early innate immune response to CRAB infection is activated in a cGAS‐STING‐dependent manner, which could be a potential therapeutic target for CRAB infection.
Targeting Caveolin‐1 in Multiple Myeloma Cells Enhances Chemotherapy and Natural Killer Cell‐Mediated Immunotherapy
Authors: Zhan Dewen , Du Zhimin , Zhang Shang , Huang Juanru , Zhang Jian , Zhang Hui , Liu Zhongrui , Menu Eline , Wang Jinheng 
Published: December 2024

AbstractThe cell membrane transport capacity and surface targets of multiple myeloma (MM) cells heavily influence chemotherapy and immunotherapy. Here, it is found that caveolin‐1 (CAV1), a primary component of membrane lipid rafts and caveolae, is highly expressed in MM cells and is associated with MM progression and drug resistance. CAV1 knockdown decreases MM cell adhesion to stromal cells and attenuates cell adhesion‐mediated drug resistance to bortezomib. CAV1 inhibition in MM cells enhances natural killer cell‐mediated cytotoxicity through increasing CXCL10, SLAMF7, and CD112. CAV1 suppression reduces mitochondrial membrane potential, increases reactive oxygen species, and inhibits autophagosome‐lysosome fusion, resulting in the disruption of redox homeostasis. Additionally, CAV1 knockdown enhances glutamine addiction by increasing ASCT2 and LAT1 and dysregulates glutathione metabolism. As a result of CAV1 inhibition, MM cells are more sensitive to starvation, glutamine depletion, and glutamine transporter inhibition, and grow more slowly in vivo in a mouse model treated with bortezomib. The observation that CAV1 inhibition modulated by 6‐mercaptopurine, daidzin, and statins enhances the efficacy of bortezomib in vitro and in vivo highlights the translational significance of these FDA‐approved drugs in improving MM outcomes. These data demonstrate that CAV1 serves as a potent therapeutic target for enhancing chemotherapy and immunotherapy for MM.
Thermal Management Approach to Stabilization of Disordered Active Sites for Sabatier Reaction
Authors: Duan Delong , Wu Di , Shou Hongwei , Hu Chuansheng , Hu Canyu , Zhou Min , Long Ran , Bi Yingpu , Xiong Yujie 
Published: December 2024

AbstractThe transition metal nanocatalysts containing disordered active sites can potentially achieve efficient Sabatier reactions with high selectivity. However, it remains a challenge to maintain the stability of these active sites in such an exothermic reaction. Here, a thermal management approach is reported to address this challenge. Specifically, an efficient and stable catalytic system is developed by integrating urchin‐like Ru nanoparticles with disordered active sites (d‐RuNUs) and multi‐walled carbon nanotubes (MWCNTs) as heat transfer framework, which achieves a CH4 yield of 3.3 mol g−1 h−1 with nearly 100% selectivity in 12 h. The characterizations reveal that the thermal‐induced crystallization seriously weakens the adsorption of CO2, leading to significant degradation of catalytic performance. The heat transfer simulation confirms that the MWCNTs with high thermal conductivity play a key role in rapidly redistributing the reaction heat, thereby preventing the crystallization of disordered structures. This work elucidates the deactivation mechanism of disordered active sites in exothermic reactions and opens the avenue for local thermal management of non‐thermal equilibrium reactions.
Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion
Authors: Tao Zaijin , Wang Shuo , Liu Jingwen , Zhu Tonghe , Jiang Jia , Liu Shen , Ma Xin 
Published: December 2024

AbstractPersistent anti‐inflammatory responses are critical for the prevention of peritendinous adhesion. Although modified anti‐adhesion barriers have been studied extensively, the immune response induced by the implants and the unclear mechanism limits their application. In this research, the advantage of the multi‐functionalities of CA (caffeic acid) is taken to synthesize biodegradable poly (ester urethane) urea elastomers with ester‐ and carbamate‐bonded CA (PEUU‐CA). PEUU‐CA is electrospun into bioactive patches that can uniquely present a sustained CA niche, referred to as BPSN. In the early stage of degradation, the breakage of the ester bond from BPSN is the dominant factor contributing to the early release of CA. In the later stage of BPSN degradation, the breakage of the ester and carbamate bonds contributes to the sustained release of CA. In vitro experiments showed that CA, when specifically bound to the P2Y12 receptor, down‐regulated the expression and function of active P2Y12, effectively inhibiting the aberrant activation of macrophages and the secretion of inflammatory chemokines. BPSN addresses the foreign body reaction induced by macrophage‐dominated biomaterial implantation and the issue of the short‐term release of drugs at later stages of adhesion, providing a feasible strategy for the prevention and treatment of tissue adhesion, and more broadly, the well‐known implant‐derived inflammatory responses.
Non‐Reciprocity, Metastability, and Dynamic Reconfiguration in Co‐Assembly of Active and Passive Particles
Authors: Al Harraq Ahmed , Patel Ruchi , Lee Jin Gyun , Owoyele Ope , Chun Jaehun , Bharti Bhuvnesh 
Published: December 2024

AbstractLiving organisms often exhibit non‐reciprocal interactions where the forces acting on the objects are not equal in magnitude or opposite in direction. The combination of reciprocal and non‐reciprocal interactions between synthetic building blocks remains largely unexplored. Here, out‐of‐equilibrium assemblies of non‐motile isotropic passive and metal‐patched motile active particles are formed by overlapping bulk interactions with directed self‐propulsion. An external alternating current (AC) electric field generates concurrent dipolar and induced‐charge electrophoretic forces between the particles which are evaluated using microscopy. The interaction force measurements allow to determine the degree of reciprocity in interactions, which is tunable by designing the active particle and its trajectory. While linearly‐propelled active particles evade assembly with passive particles, helically propelled active particles form active‐passive clusters with dynamic reconfiguration and long‐lived metastability. Large clusters display programmable fluctuations and reconfigurability by controlling the fraction of active particles. The study establishes principles of integrating reciprocal and non‐reciprocal interactions in guided colloidal assembly of reconfigurable metastable structures.
High‐Throughput Single‐Nucleus RNA Profiling of Minimal Puncture FFPE Samples Reveals Spatiotemporal Heterogeneity of Cancer
Authors: Jiang Weiqin , Zhang Xiang , Xu Ziye , Cheng Qing , Li Xiaohan , Zhu Yuyi , Lu Fangru , Dong Ling , Zeng Linghui , Zhong Weixiang , Wang Yongcheng , Fan Longjiang , Chen Hongyu 
Published: December 2024

AbstractPuncture biopsy, especially those preserved by formalin fixed paraffin embedding (FFPE) samples, play an important role in various research purposes. Diverse single‐nucleus RNA sequencing (snRNA‐seq) techniques have been developed for FFPE samples, however, how to perform high‐throughput snRNA‐seq on small FFPE puncture samples is still a challenge. Here, the previously developed snRNA‐seq technique (snRandom‐seq) is optimized by implementing a pre‐indexing procedure for the minimal puncture FFPE samples. In analyzing 20 samples from various solid tumors, optimized snRandom‐seq still detected ≈17 000 genes and 12 000 long non‐coding RNAs (lncRNAs), achieving precise clustering based on tissue origin. A head‐to‐head comparison with 10× Genomics on fresh biopsy samples showed a similar gene detection rate, with significantly enhanced lncRNA detection, indicating that the optimized snRandom‐seq technique maintains its established gene detection advantages even when applied to small samples. Utilizing 7 puncture FFPE samples of liver metastases from 3 colorectal cancer patients pre‐ and post‐immunotherapy, the cellular developmental trajectories are reconstructed and revealed dynamic spatiotemporal heterogeneity during treatment, including insights into pseudoprogression of immunotherapy. Therefore, the optimized snRandom‐seq offers a solution for high‐throughput single‐cell RNA and non‐coding RNA analysis in minimal puncture FFPE sample.
Programmable Multiplexed Nucleic Acid Detection by Harnessing Specificity Defect of CRISPR‐Cas12a
Authors: Guan Xin , Yang Rui , Zhang Jiongyu , Moon Jeong , Hou Chengyu , Guo Chong , Avery Lori , Scarola Danielle , Roberts Daniel S. , LaSala Rocco , Liu Changchun 
Published: December 2024

AbstractCRISPR‐Cas12a works like a sophisticated algorithm in nucleic acid detection, yet its challenge lies in sometimes failing to distinguish targets with mismatches due to its specificity limitations. Here, the mismatch profiles, including the quantity, location, and type of mismatches in the CRISPR‐Cas12a reaction, are investigated and its various tolerances to mismatches are discovered. By harnessing the specificity defect of the CRISPR‐Cas12a enzyme, a dual‐mode detection strategy is designed, which includes approximate matching and precise querying of target sequences and develop a programmable multiplexed nucleic acid assay. With the assay, 14 high‐risk human papillomavirus (HPV) subtypes are simultaneously detected, collectively responsible for 99% of cervical cancer cases, with attomolar sensitivity. Specifically, the assay not only distinguishes HPV16 and HPV18, the two most common subtypes but also detects 12 other high‐risk pooled HPV subtypes. To enable low‐cost point‐of‐care testing, the assay is incorporated into a paper‐based microfluidic chip. Furthermore, the clinical performance of the paper‐based microfluidic chip is validated by testing 75 clinical swab samples, achieving performance comparable to that of PCR. This programmable multiplexed nucleic acid assay has the potential to be widely applied for sensitive, specific, and simultaneous detection of different pathogens.
Novel Ru‐O3Se4 Single Atoms Regulate the Charge Redistribution at Ni3Se2/FeSe2 Interface for Improved Overall Water Splitting in Alkaline Media
Authors: Guo Linke , Liu Tianpeng , Zhang Le , Ma Mengyao , Gao Peng , Cao Dong , Cheng Daojian 
Published: December 2024

AbstractDeveloping low‐cost, highly active, and stable bifunctional catalysts is of great significance for electrochemical water splitting. Herein, novel Ru‐O3Se4 single atoms doped Ni3Se2/FeSe2 interface catalyst is fabricated by a two‐step method for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Notably, Ru‐Ni3Se2/FeSe2 nanosheets exhibit excellent HER (43 mV@10 mA cm−2) and OER (283 mV@100 mA cm−2) activities in alkaline solution. In particular, the mass activity of Ru‐Ni3Se2/FeSe2 catalyst is 3593.61 mA mg Ru−1 at 200 mV for HER and 7073.80 mA mgRu−1 at 400 mV for OER, which is 25.91 and 367.28 times of commercial Pt/C and RuO2, respectively. In situ spectroscopy techniques confirm Ru‐O3Se4 single atoms facilitate the adsorption of intermediates H* and OOH* during HER and OER processes, respectively. Further density functional theory calculations reveal introducing Ru‐O3Se4 single atoms causes the transfer of electrons from Ru to Ni and Fe atoms, leading to a redistribution of charge at the Ni3Se2/FeSe2 interface, thus reducing the energy barriers of rate‐determining step to −0.37 and 1.92 eV for HER and OER, respectively. This work emphasizes the significant role of single atoms at the interface for overall water splitting.
Combined In Situ X‐Ray Spectroscopic and Theoretical Study on Trimetal Synergistic Enhancement of Water Oxidation
Authors: Fan Yalei , Ye Xubin , Zhou Jing , Lu Dabiao , Kuo Chang‐Yang , Huang Yu‐Cheng , Chan Ting‐Shan , Chen Chien‐Te , Long Youwen , Wang Jian‐Qiang , Hu Zhiwei , Zhang Linjuan 
Published: December 2024

AbstractElectrochemical water‐splitting is vital in energy storage and conversion applications. However, the sluggish kinetics of the oxygen evolution reaction (OER) hinders the electrochemical water‐splitting. Therefore, developing efficient catalysts and understanding the OER mechanism are highly desirable. This study successfully synthesized a new quadruple perovskite oxide CaCu3Co2Ru2O12 (CCCRO) catalyst exhibiting high OER activity with overpotential 198 mV at 10 mA cm−2, a Tafel slope of 37 mV dec−1, and long‐term operational stability with a current density of 500 mA cm−2 for >500 h. The in situ X‐ray absorption near‐edge structure (XANES) indicated that a part of high‐spin (HS) Co3+ ions and low‐spin (LS) Ru5+ ions transitioned to the tetravalent Co (IV) and hexavalent Ru (VI) valence states under OER. However, the Cu2+ valence state remained unchanged. Furthermore, the density functional theory (DFT) calculations reveal that the lattice‐oxygen oxidation mechanism (LOM) rather than conventional adsorbate evolution mechanism (AEM) is responsible for high OER activity in Ru (VI)‐O‐Co (IV) network, and that the Cu(A’)/Co(B)/Ru(B’) three sites synergistically facilitate the OER activity for CCCRO.
Identifying and Prioritizing Hazardous Chemicals in Construction Metal Structure Coating Systems: A Roadmap for Data‐Driven Disease Prevention
Authors: Patel Paridhi , Bello Dhimiter , Bello Anila 
Published: December 2024

ABSTRACTIntroductionOccupational exposure as a painter was classified by the International Agency for Research on Cancer (IARC) as a Group 1 carcinogen (carcinogenic to humans) in 1989. Chemical agents responsible for cancers and other illnesses among industrial painters are not well‐documented. The goal of this systematic review and synthesis was to document the chemistries of metal structure coating systems, summarize data gaps on occupational exposures and health effects among painters, and identify and prioritize hazardous chemicals to guide future exposure and occupational health studies, and ultimately disease prevention efforts.MethodsWe reviewed coating products approved by the Northeast Protective Coating Committee (NEPCOAT) for use in steel bridges in New England, with a special focus on Part B of these reactive chemical systems, and related literature on exposures and health effects.ResultsFrom the review of safety datasheets (SDS), we identified 61 unique CAS numbers belonging to different Part B chemical groups of isocyanate‐ and epoxy‐based formulations, including amine hardeners, solvents, nanomaterials, and other additives. The list of identified ingredients contained 14 potent sensitizers, two IARC Group 1 known carcinogens, and 7 IARC Group 2B possible carcinogens. Cancers of the lungs, urinary bladder, liver, kidneys, and gastrointestinal system, allergic contact dermatitis, lung fibrosis, and asthma were some possible disease endpoints. Existing occupational exposure studies focused on solvent exposures, while exposure and biomonitoring studies of amine hardeners and other ingredients of concern in these formulations are lacking.ConclusionsThe list of chemicals of concern identified here, including sensitizers and carcinogens, can serve as a basis for analytical method development and field exposure assessment studies. A national multi‐pronged strategy to reduce chemical exposures and health risks among construction painters is warranted, including research on exposure monitoring and reduction efforts, longitudinal epidemiological studies, and product reformulation.