bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Estradiol in the Expression of Genes Involved in Serotonin Neurotransmission: Implications for Female Depression
Authors: Hernández-Hernández Olivia Tania , Martínez-Mota Lucía , Herrera-Pérez José Jaime , Jiménez-Rubio Graciela 
Published: June 2018

Background:In women, changes in estrogen levels may increase the incidence and/or symptomatology of depression and affect the response to antidepressant treatments. Estrogen therapy in females may provide some mood benefits as a single treatment or might augment clinical response to antidepressants that inhibit serotonin reuptake.Objective:We analyzed the mechanisms of estradiol action involved in the regulation of gene expression that modulates serotonin neurotransmission implicated in depression.Method:Publications were identified by a literature search on PubMed.Results:The participation of estradiol in depression may include regulation of the expression of tryptophan hydroxylase-2, monoamine oxidase A and B, serotonin transporter and serotonin-1A receptor. This effect is mediated by estradiol binding to intracellular estrogen receptor that interacts with estrogen response elements in the promoter sequences of tryptophan hydroxylase-2, serotonin transporter and monoamine oxidase-B. In addition to directly binding deoxyribonucleic acid, estrogen receptor can tether to other transcription factors, including activator protein 1, specificity protein 1, CCAAT/enhancer binding protein β and nuclear factor kappa B to regulate gene promoters that lack estrogen response elements, such as monoamine oxidase-A and serotonin 1A receptor.Conclusion:Estradiol increases tryptophan hydroxylase-2 and serotonin transporter expression and decreases the expression of serotonin 1A receptor and monoamine oxidase A and B through the interaction with its intracellular receptors. The understanding of molecular mechanisms of estradiol regulation on the protein expression that modulates serotonin neurotransmission will be helpful for the development of new and more effective treatment for women with depression.
Association of Serum Homocysteine Level and Interstitial Lung Disease in Systemic Sclerosis: A Case-control Study
Authors: Nazarinia Mohammadali , Zare Asghar , Fallahi Mohammad javad , Shams Mesbah 
Published: June 2018

Background:Systemic sclerosis is a disorder of connective tissue with unknown cause, affecting the skin and internal organs, characterized by fibrotic changes.Objective:To determine the correlation between serum homocysteine level and interstitial lung involvement in systemic sclerosis. </P><P> Materials and Methods: In this case – control study, 59 patients who fulfilled the ACR/EULAR classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran, were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients were divided into two groups based on interstitial lung involvement and two subtypes, diffuse and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls, and cases groups.Results:Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and 38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was 13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum homocysteine level did not differ between the patients with and without interstitial lung involvement (P=0.52). The patients with lung involvement was older than those without lung involvement (P=0.004). Lung disease was more common in diffuse type (P=0.014).Conclusion:In our study, serum homocysteine level did not differ between the patients and healthy subjects. Also, there was no correlation between serum homocysteine level and lung involvement, but lung involvement was more common in older patients and also diffuse subtype.
Lead Molecule Prediction and Characterization for Designing MERS-CoV 3C-like Protease Inhibitors: An In silico Approach
Authors: Rahman Md. Mostafijur , Hosen Md. Bayejid , Howlader M. Zakir Hossain , Kabir Yearul 
Published: June 2018

Background:
3C-like protease also called the main protease is an essential enzyme for the
completion of the life cycle of Middle East Respiratory Syndrome Coronavirus. In our study we predicted
compounds which are capable of inhibiting 3C-like protease, and thus inhibit the lifecycle of
Middle East Respiratory Syndrome Coronavirus using in silico methods.
</P><P>
Methods: Lead like compounds and drug molecules which are capable of inhibiting 3C-like protease
was identified by structure-based virtual screening and ligand-based virtual screening method. Further,
the compounds were validated through absorption, distribution, metabolism and excretion filtering.

Results:
Based on binding energy, ADME properties, and toxicology analysis, we finally selected 3
compounds from structure-based virtual screening (ZINC ID: 75121653, 41131653, and 67266079)
having binding energy -7.12, -7.1 and -7.08 Kcal/mol, respectively and 5 compounds from ligandbased
virtual screening (ZINC ID: 05576502, 47654332, 04829153, 86434515 and 25626324) having
binding energy -49.8, -54.9, -65.6, -61.1 and -66.7 Kcal/mol respectively. All these compounds have
good ADME profile and reduced toxicity. Among eight compounds, one is soluble in water and remaining
7 compounds are highly soluble in water. All compounds have bioavailability 0.55 on the
scale of 0 to 1. Among the 5 compounds from structure-based virtual screening, 2 compounds showed
leadlikeness. All the compounds showed no inhibition of cytochrome P450 enzymes, no blood-brain
barrier permeability and no toxic structure in medicinal chemistry profile. All the compounds are not a
substrate of P-glycoprotein.

Our predicted compounds may be capable of inhibiting 3C-like protease but need some
further validation in wet lab.
Synthesis, Characterization and Evaluation of Antimicrobial Properties of (R)-(-)-4-Phenyl-2 Oxazolidinone Based Azetidinones
Authors: Baruah Shyamal , Puzari Amrit , Sultana Farhana , Barman Jayanta 
Published: June 2018

Introduction:
A series of (R)-(-)-4-Phenyl-2 oxazolidinone based azetidinones (4a-i) were
synthesized from the reaction of (2-Oxo-4-phenyl-oxazolidin-3-yl) acetic acid with aromatic imines (3a-i)
in the presence of Thionyl chloride and Triethylamine as a base.

Methods:

The transformation proceeds through the formation of acid chloride to ketene which finally
forms the azetidinones through [2+2] cycloaddition with aromatic imines. Products obtained were
screened to evaluate their antibacterial activity with respect to known bacteria like Escherichia Coli (E.
Coli) and Bacillus subtilis.

Results and Conclusion:

In most of the cases, azetidinones were found to exhibit superior antimicrobial
properties than oxazolidinones. They were found to be a good inhibitor of gram-positive and gramnegative
bacteria. Enhancement of antibacterial property can be attributed to the presence of azetidinone
ring and hydrophobic alkyl side chain in the scaffolds.
El mito del bilingüismo y la colonización lingüística en Paraguay
Authors: Makaran Kubis Gaja Joanna 
Published: June 2018

<p class="p1">El presente artículo tiene como objetivo desmitificar las narrativas nacionales acerca de la cuestión lingüística en Paraguay y descubrir las relaciones injustas de poder y dominación que estas esconden. La autora analiza el presunto bilingüismo paraguayo como un fenómeno sociocultural más que lingüístico e indica que es un mito y una creación discursiva nacionalista destinado a legitimar la colonización lingüística. Tras presentar la genealogía, las funciones y los objetivos del mito, se procede a su sucesiva desmitificación, tanto desde la perspectiva histórica, como también a partir de las actuales políticas lingüísticas en el país. </p>
El gran desafío de los indígenas en los países andinos: sus derechos sobre recursos naturales
Authors: Albó Xavier 
Published: June 2018

<p class="p1">No hablaré en abstracto sobre este futuro. Analizaré más bien en cierto detalle algunos procesos actuales, con un estilo más narrativo que teórico, para prever temas que seguirán candentes en el futuro próximo. Me fijaré sobre todo en dos asuntos para mí centrales y muy entrelazados: la relación de los pueblos indígenas con el manejo de ciertos recursos naturales estratégicos en sus territorios y, para ello, también su derecho, reconocido en recientes documentos internacionales, a ser consultados de buena fe, de manera previa, libre e informada. Este trabajo tiene algo de puente y trampolín hacia el futuro desde otro libro reciente sobre los movimientos y poder indígena en Bolivia, Ecuador y Perú (Albó 2008/2009). Al final se enumeran telegráficamente otros cuatro temas también muy relevantes en el futuro cercano. </p>
Retención de membranas fetales y patologías uterinas en vacas lecheras tratadas con PGF2α después del parto
Authors: Valdés Pérez Luis Ángel , Hernández Cerón Joel , Luzbel de la Sota Rodolfo , Aréchiga Flores Carlos Fernando , Salgado Hernández Eligio Gabriel , Romero Arredondo Antonio 
Published: June 2018

Se probó si la administración de dos inyecciones de PGF2α en las primeras 48 h posparto disminuye la incidencia de retención de las membranas fetales (RMF) y de patologías uterinas en vacas lecheras. Se utilizaron 800 vacas de diferente número de partos, las cuales se asignaron aleatoriamente a dos tratamientos; PGF2α (n= 400) recibieron una inyección de PGF2α (500 μg de cloprostenol sódico) en las primeras 12 h posparto y una segunda inyección 48 h después; testigo (n= 400) no recibió PGF2α. Se registró la incidencia de RMF (vacas que no eliminaron la placenta de las siguientes 24 h posparto) y de patologías uterinas (metritis y endometritis), tasa de gestación en el primer servicio y porcentaje de vacas gestantes en el día 150 posparto. Las vacas testigo tuvieron mayor probabilidad de RMF (Odds ratio 1.69; P= 0.01) que las vacas tratadas con PGF2α. La proporción de vacas con patologías uterinas en el día 28 posparto fue menor (P= 0.01) en las vacas tratadas con PGF2α (29.8 %) que en las testigo (36.7 %). La tasa de gestación en el día 150 posparto fue mayor en las vacas con involución normal que en las vacas con patologías uterinas (Odds ratio 1.4, P=0.03). Se concluye que dos inyecciones de PGF2α en las primeras 48 h posparto (primeras 12 y 48 h posparto) disminuyen la incidencia de RMF y de patologías uterinas en vacas lecheras.
Analysis of Crop Yield Prediction of Kharif & Rabi Jowar Crops Using Data Mining Techniques
Authors: Mulik Sujata 
Published: June 2018

Agriculture sector in India is facing rigorous problem to maximize crop productivity. More than 60 percent of the crop still depends on climatic factors like rainfall, temperature, humidity. This paper discusses the use of various Data Mining applications in agriculture sector. Data Mining is used to solve various problems in agriculture sector. It can be used it to solve yield prediction. The problem of yield prediction is a major problem that remains to be solved based on available data. Data mining techniques are the better choices for this purpose. Different Data Mining techniques are used and evaluated in agriculture for estimating the future year's crop production. In this paper we have focused on predicting crop yield productivity of kharif & Rabi Crops.
Implementation for a Digital Watermarking Algorithm on Different Image Format Types
Authors: Aldwairi Khaldoon , Al-Hadidi Meran M. 
Published: June 2018

Digital watermarking can be defined simply as hiding a message in a digital image, song or video. Watermarking is widely being used for many applications. In this paper a secure image watermarking algorithm using array extraction from the original image will be implemented on different types of images using MATLAB code. The algorithm was proposed to send a message through an image by extracting 5 binary arrays of size (1x5) containing 1 and 0 from that used image, and then the binary arrays would be updated in a way that they can carry the secret message of 5 letters or less. In this paper the same algorithm will be implemented by extracting first, 5 binary arrays of size (1x5) containing 1 and 0 from that image to send a message composed of 5 numbers, each number of two digits. Then extracting 6 binary arrays of size (1x6) containing 1 and 0 from the same image, and the binary arrays also would be updated in a way that they can carry the secret message of 6 numbers, each number of two digits. Also this algorithm by extracting 5 arrays or 6 arrays will be implemented on different image format types to find out what is the suitable image format to be used in this algorithm, with no noticeable image distortion or loss in its size, to ensure the algorithm strength and security to send secret numbers or passwords through images. The same algorithm will be implemented to send secret numbers. First by using the first 25 pixels from any used image by extracting 5 binary arrays of size (1x5), then by using the first 36 pixels from the same used image by extracting 6 binary arrays of size (1x6) and making a comparison between both results using MATLAB.
Digital Chain of Custody
Authors: Sadiku Matthew N.O. , Shadare Adebowale E. , Musa Sarhan M. 
Published: June 2018

Digital chain of custody is the record of preservation of digital evidence from collection to presentation in the court of law. This is an essential part of digital investigation process. Its key objective is to ensure that the digital evidence presented to the court remains as originally collected, without tampering. The chain of custody is important for admissible evidence in court. Without a chain of custody, the opposing attorney can challenge or dismiss the evidence presented. The aim of this paper is to provide a brief introduction to the concept of digital chain custody.
Developing and Validating a M-Governance Framework Adoption Model of a University for Communication Services to Its Affiliated Institutions
Authors: Ramganesh E. , Kirubakaran E. , Ravindran D. , Gobi R. 
Published: June 2018

The m-Governance framework of auniversity aims to utilize the massive reach of mobile phones and harness the potential of mobile applications to enable easy and round the-clock access to the services of its affiliated institutions. In the current mobile age there is need for transforming e-governance services to m-Governance as m-Governance is not a replacement for e-Governance rather it complements e-Governance. With this unparalleled advancement of mobile communication technologies, universities are turning to m-governance to realize the value of mobile technologies for responsive governance and measurable improvements to academic, social and economic development, public service delivery, operational efficiencies and active stakeholder engagement. In this context the present study, aims to develop and validate a m-governance framework of a university by extending Technology Acceptance Model (TAM) with its prime stakeholders so called the Heads of the affiliated institutions. A survey instrument was developed based on the framework and it was administered with 20 Heads of the affiliated Institutions. The results also showed that the Heads of the affiliated Institutions expressed their favorableness towards m-governance adoption.
Software Development by Merging Prototyping and Agile Approaches
Authors: Al-Refai Mohammed , Zughoul Basem , Al-Raba’nah Yousef , Alauthman Mohammad , Muraish Ahmad 
Published: June 2018

during the past four decades, new software development approaches were presented to going with new trends of the software development companies and developers. Nowadays most software companies search to customise short period and minimal costs to produce valuable software products. These productions are within unstable, changing environments. Agile Methodologies were thus introduced to achieve the new requirements of the software development companies. Agile development invented for handling change. The key benefit of agile methodology is used to simplify the change-oriented software engineering process, but agile methodology needs to take more consideration to user point of view. Although the weaknesses of prototyping approach have, it can be used effectively by end users to describe requirements that developers may not have considered. This paper presents a proposed framework based on merge prototyping and agile approaches not only to cure the weaknesses of agile development and prototype methodology but to enrol the user in every single step, which will lead to faster and much accepted overall results.
NATURAL COMPUTING
Authors: Sadiku Matthew N. O. , Tembely Mahamadou , Musa Sarhan M. 
Published: June 2018

Natural computing refers to the field that investigates both human-designed computing inspired by nature and computing taking place in nature. It is based on the premise that “nature computes.” Due of its interdisciplinary nature, natural computing covers a spectrum of research areas including biology, chemistry, physics, computer science, and engineering. This paper provides a brief introduction to natural computing.
Review on Network Security and Cryptography
Authors: . Kajal , Khan Rizwan 
Published: June 2018

In these days communication technology is very advanced. Digital communication has become very important to secure transmission of information between the sender and the receiver. Security for exchange is a very important feature because it protects information from interloper. In this paper we present a hierarchy of network security technologies such as privacy, authentication, non-rejection and honesty control. There are two popular security mechanisms, namely cryptography and steganography. Both are well known and widely used techniques. Cryptography is used to send data in an encrypted form using the encryption key. Encrypted data is transmitted through unsafe public media. Decryption algorithms are also used to decrypt messages when using decryption keys. Steganography is used to hide data in other cover media.
Security Issues of Firewall
Authors: Periyasamy A R. Pon 
Published: June 2018

The need of Network Security is accelerating at the same pace as that of increased Internet usage. Network Security prevents from illegitimate admittance, hacking andauthentic data transportation. Network Security consist of provisions and policies adopted by a network administrator to preclude and monitor unauthorized access, alterations, perversion, declination of a computer network and network-accessible resources. Network Security is achieved by Firewall. Firewall is a hardware or software device which is designed to permit or refuse network transmissions based upon certain protocols. Firewall is a locus at the endpoints of the system which strains out all illegitimate traffic and users. But conventional or traditional firewalls rely stricly on the restricted topology and restrained entry points to function; which results in difficulty in filtering certain protocols, end-to-end encryption problem etc. Hence, it resulted in the evolution of Distributed Firewall which strengthens the network security policies without delimitating its topology from inside or outside. Distributed Firewall is a host-resident security software application that protects the enterprise network’s servers and end-user machines against unwanted intrusion. This paper is a literature review paper focusing on traditional firewalls, it evolution, security issues various policies and the concept of distributed firewall.
A Comparative Study of Low Power Testing Techniques for Digital Circuits
Authors: Shirol Suhas B , Shettar Rajashekar B 
Published: June 2018

In recent years, with fast growth of mobile communication and portable computing systems, design for low power has become the challenge in the field of Digital VLSI design. The main focus of the paper is to make a comparative study of low power Linear Feedback Shift Register (LFSR) architecture such as Built In Self Test (BIST), it has been often seen that during test mode process the power consumed is much higher, when compared to that of normal mode process test as there is high switching activity in the nodes of Circuit Under Test(CUT) during testing.
An Advanced Tree Based Energy Routing Protocol
Authors: Kamble Sonam Ashok , Kale Dilip S. 
Published: June 2018

A wireless sensor network (WSN) consists of hundreds to thousands of sensor nodes, working in any physical environment, and having sensing, computation and communication capabilities. Each sensor node in WSN is capable of communicating with each other and the base station (BS) for the purpose of data integration and dissemination. As the battery replacement is not easy for WSN with thousands of physically embedded nodes, energy conservation becomes one of the most important challenges in WSNs. And hence there is a need for energy efficient routing protocol to offer a long-life work time. In this paper, we propose an Advanced Tree Based Energy Routing Protocol. In this protocol for each round BS assigns a root node and broadcasts this selection to all sensor nodes. And then each node selects its parent by considering itself and its neighbour’s information, thus making it a dynamic protocol. It is a hierarchical protocol of WSN which increases the lifetime of network by using the energy of the network by using the energy of the network in an efficient way.
Survey of Cloud Computing in Healthcare Sector
Authors: Devi S. Karthiga , Arputhamary B. 
Published: June 2018

Today the volume of healthcare data generated increased rapidly because of the number of patients in each hospital increasing. These data are most important for decision making and delivering the best care for patients. Healthcare providers are now faced with collecting, managing, storing and securing huge amounts of sensitive protected health information. As a result, an increasing number of healthcare organizations are turning to cloud based services. Cloud computing offers a viable, secure alternative to premise based healthcare solutions. The infrastructure of Cloud is characterized by a high volume storage and a high throughput. The privacy and security are the two most important concerns in cloud-based healthcare services. Healthcare organization should have electronic medical records in order to use the cloud infrastructure. This paper surveys the challenges of cloud in healthcare and benefits of cloud techniques in health care industries.
Design Two Dimensional Nanocavity Photonic Crystal Biosensor Detection in Malaria
Authors: Sharma Varsha , Kalyani Vijay Laxmi 
Published: June 2018

In this paper we design a two dimensional (2-D) photonic crystal based biosensor implemented by linear waveguide and nanocavity detection in malaria. The bio molecules such as a red blood cell, infected red blood cell, trapped inside the nanocavity cause transmission shift at the output terminal. The sensing mechanism of biosensor is change in refractive index of analytes. The layout biosensor is consists a linear waveguide with a nanocavity in square symmetry For the proposed photonic based biosensor, the band gap from 2210nm to 1420 nm and input wavelength of 1550nm are used in this design. The simulation results have analysed by using the finite difference time domain (FDTD) method, bandgap calculation is performed using plane wave expansion method.
Impact of GST on Automobile Sector in India
Authors: Lavanya V. , Kumar D. Pradeep , Reddy T. Narayana 
Published: June 2018

The Automobile industry in India is one of the most successful manufacturing space from past liberalization. The industry has potential to grow to become a major economic contributor. The Government of India has also recognized the importance of Automobile industry holds in the Indian economy and hence is currently working on Automotive Mission Plan 2026 to set targets for the industry for the year 2026. The Government of India has planned to implement of GST to the manufacturing sector in India. The objective of this study is the impact of GST on Automobile sector in India.