bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropsichyatric Manifestations of Systemic Lupus Erythematosus: Diagnosis and Treatment Approach
Authors: Lucic Alesandra Tomic 
Published: November 2018

Abstract
Neuropsychiatric involvement in systemic lupus erythematosus includes heterogeneous manifestations involving both the central and peripheral nervous system. A major issue in clinical evaluation is the attribution of neuropsychiatric symptoms to systemic lupus erithematosus. Antiphospholipid antibodies, immune complex, microangiopathy, early and accelerated arteriosclerosis are factors that have the main role in pathogenesis of neuropsychiatric manifestations of systemic lupus erithematosus. Th ere are no neurological symptoms specific to systemic lupus erithematosus, but they can also occur very commonly in the general population. Lesions of nervous system can be focal or diff use and may be due to systemic lupus erithematosus itself (primary lesions), but it also may be caused by other diseases or disbalances. Therapy of the neuropsychiatric manifestations depends on the nature of the pathological process (dominant inflammation or thrombosis). If it is result of an inflammatory neurotoxic process and in the presence of an increased activity of systemic lupus erithematosus, therapy includes glycocorticoids independently or in combination with immunosuppressives. Focal neuropsychiatric syndrome with antiphospholipid antibodies positivity should be treated with anticoagulant and/ or antiplatelet therapy. In addition, control of classical cardiovascular risk factors, stop smoking, and treatment with hydroxychloroquine is recommended.
The Influence of Bond Angle on Thermophysical Properties of Three-Center Lennard-Jones Fluids: Computer Simulation and Theory
Authors: Laghaei Rozita , Nasrabad Afshin Eskandari 
Published: November 2018

Abstract
We carry out extensive computer simulations to study the phase equilibrium, thermodynamics, and diffusion coefficient of three-center Lennard-Jones (3CLJ) fluids with an emphasis on the effects of bond angle on these properties. We take into account several bond angles ranging from θ
0 = 60 to 180 degrees and two equilibrium bond elongations le
= 1.0 and 0.5 (in Lennard-Jones length unit). Moreover, we study the fully flexible (FF) 3CLJ fluids for molecules with bond length 1.0. Gibbs ensemble Monte Carlo (MC) simulations are performed to compute the densities of the vapor-liquid coexisting phases and the vapor pressure, and direct three-phase (vapor-liquid-vapor) molecular dynamics (MD) simulations are carried out to calculate the surface tension. We then apply constant NVT MC simulations to obtain the internal energy, the pressure, and the pair correlation function, and utilize equilibrium MD simulations to compute the diffusion coefficient of systems with le
= 1.0. In addition to MD simulations, the modified Cohen-Turnbull (mCT) theory is used to to compute the diffusion coefficient and the mean free volume appearing in the mCT relation is provided by the results of the Generic van der Waals (GvdW) theory. We show that the mCT theory is capable of reproducing the MD simulation values quite well over a wide range of density with slight overestimations at medium range. The angle dependence of different thermophysical properties are analyzed and discussed in details.
Indigenous Environmental Justice, Knowledge, and Law
Authors: McGregor Deborah 
Published: November 2018

This article aims to introduce a distinct conception of Indigenous environmental justice (IEJ) based on Indigenous legal orders, knowledge systems, and conceptions of justice. This is not to suggest in any way that the existing environmental justice (EJ) scholarship is flawed; in fact, the scholarship and activism around EJ have been central in diagnosing and drawing attention to injustices that occur on a systematic basis everywhere in the world. This article argues instead that such discussions can be expanded by acknowledging that concepts of environmental justice, including distinct legal orders informed by Indigenous knowledge systems, already existed on Turtle Island for thousands of years prior to the arrival of Europeans. It also suggests that environmental justice framed within Indigenous worldviews, ontologies, and epistemologies may make significant contributions to broader EJ scholarship, particularly in relation to extending justice to other beings and entities in Creation. This approach acknowledges ongoing colonialism and emphasizes the need to decolonize in order to advance innovative approaches to IEJ.
Study on management of fungal infections of nose and parnasal sinuses
Authors: Kelkar Prasad A. , Hirekerur Jyoti V. 
Published: November 2018

<p class="abstract"><strong>Background:</strong> From last few years, the fungal infection has been increasing due to greatly enhanced international traffic and as opportunistic infections in consequence of use of powerful cytotoxic drugs. The disease invariably occurs in diabetics, usually with ketoacidosis, immune compromised patients. Hence, we planned to undertake the present study to evaluate a standard method of management of fungal infections of nose and paranasal sinuses.</p><p class="abstract"><strong>Methods:</strong> A detailed examination of the nose and pranasal sinuses was carried out in the department of ENT. The patients were continuously monitored with pulse oximetry and ECG monitor. In all patients, nasal endoscopy was performed. </p><p class="abstract"><strong>Results:</strong> In this study, fungal infections of the nose and paranasal sinuses were found to be common between 20 and 50 years of age. Aspergillosis was the commonest sinonasal fungal infection followed by allergic fungal sinusitis, rhinosporidiosis and mucormycosis.</p><p class="abstract"><strong>Conclusions:</strong> Early detection, proper and adequate dose of antifungal agents, timely surgical intervention in the form of debridement and sphenoethmoidectomy and orbital exenteration improve the survival rate in the disease of sinonasal fungal infections.</p><p> </p>
Thermodynamic Analysis of a Modified Autonomous Flow Control Device for SAGD Sub-Cool Management
Authors: Konopczynski Michael 
Published: November 2018

Abstract
This paper describes the application of Autonomous Inflow Control Devices to manage sub-cool in SAGD bitumen production wells. A modification of the AICD is proposed to increase the effectiveness of its performance restricting premature steam breakthrough.
Typical nozzle, short tube, and hybrid type passive ICD's are good at creating uniform inflow by creating additional pressure drop and flow restriction along the length of the wellbore, but once the steam/water interface reaches the device, the steam preferentially flow through at a higher rate with less pressure drop, creating further pressure drop in the steam chamber surrounding the device, more steam flashing, and a runaway situation which can only be cured by increasing the back pressure on the whole well.
The Autonomous Inflow Control Device (AICD) is an active flow control device that delivers a variable flow restriction in response to the properties of the fluid flowing through it. The RCP type of autonomous inflow control device (AICD) is much more effective in restricting vapour phased flow compared to liquid phased flow. The flow resistance of the RCP AICD is dictated by the viscosity and density of the fluid entering the device, not by what exits. As such, it does not create maximum flow resistance until steam reaches it, and for the SAGD process, this is too low a sub-cool value. By adding a small pressure drop upstream of the AICD, the device can respond to the onset of steam flashing, creating a significant pressure restriction and maintaining the desired sub-cool.
To ensure the proper design of the device and demonstrate its effectiveness in controlling steam flashing, the flow performance must be modelled honouring the thermodynamics of the associated phase changes.
The performance of the modified AICD is analysed in its ability to produce bitumen and water with minimum pressure drop while providing maximum control of wellbore steam flashing. Thermodynamic modelling demonstrates the ability of the modified AICD to reduce the impact of downstream pressure on the maintenance of desired sub-cool, allowing all zones in the SAGD wellbore to be produced at optimum drawdown and maximum rates. The study examines the performance of the device at a variety of flow rates, fluid types, and water conditions upstream of the device, from 10 C sub-cool to 10% steam quality, and compares it to the performance of traditional flow control devices.
The modified AICD provides a new and effective approach to managing SAGD sub-cool and maximizing bitumen productivity from a SAGD well, and ultimately improving steam chamber conformance and SAGD economics.
Reduction of Surfactant Retention in Limestones Using Sodium Hydroxide
Authors: Wang D.. , Maubert M.. , Pope G. A. , Liyanage P. J. , Jang S. H. , Upamali K. A. , Chang L.. , Tagavifar M.. , Sharma H.. , Ren G.. , Mateen K.. , Ma K.. , Bourdarot G.. , Morel D.. 
Published: November 2018

SummaryGeochemical modeling was used to design and conduct a series of alkaline/surfactant/polymer (ASP) coreflood experiments to measure the surfactant retention in limestone cores using sodium hydroxide (NaOH) as the alkali. Surfactant/polymer (SP) coreflood experiments were conducted under the same conditions for comparison. NaOH has been used for ASP floods of sandstones, but these are the first experiments to test it for ASP floods of limestones. Two studies performed under different reservoir conditions showed that NaOH significantly reduced the surfactant retention in Indiana Limestone. An ASP solution with 0.3 wt% NaOH has a pH of approximately 12.6 at 25°C. The high pH increases the negative surface charge of the carbonate, which favors lower adsorption of anionic surfactants. Another advantage of NaOH is that low concentrations of only approximately 0.3 wt% can be used because of its low molecular weight and its low consumption in limestones. Most reservoir carbonates contain gypsum or anhydrite, and therefore sodium carbonate (Na2CO3) will be consumed by the precipitation of calcium carbonate (CaCO3). As shown in the two studies, NaOH can be used in limestone reservoirs containing gypsum or anhydrite.
An Enriched Approach for Modeling Multiscale Discrete-Fracture/Matrix Interaction for Unconventional-Reservoir Simulations
Authors: Xia Yang , Jin Yan , Chen Mian , Chen Kang Ping 
Published: November 2018

SummaryUnconventional reservoirs after formation-stimulation treatments are always characterized by complex fracture networks with a wide range of length scales and topologies. Accurate simulation on multiscale discrete-fracture/matrix interaction during transient productive flows for such reservoirs is challenging but important for reservoir evaluation, optimization, and management.In this paper, we present a new enriched and explicit method for simulation on multiscale discrete-fracture/matrix modeling (EE-DFM) on structured grids to decouple the mesh conformity between the porous media and the fractures. A hybrid structured EE-DFM is first introduced, and enrichments for different scales of fracture segments are proposed to locally enrich the conventional approximation space for representing the pressure solution surrounding multiscale fracture networks. By appropriately selecting an asymptotic function to locally enrich the conventional approximation space, typical behavior of fluid flux around features in fractured media, such as discontinuities and singularities, can be directly captured. Simulation on complex multiscale fracture networks is achieved by using the superposition principle of the enrichments without introducing additional degrees of freedom and while maintaining computational efficiency. We demonstrate the accuracy and flexibility of the method by performing a series of case studies and comparing the results with simple analytical solutions as well as with conventional numerical solutions. The results of long-term well-performance case studies are used to show the good computational efficiency of the proposed method when the complexity of fracture networks is increased. The potential of the proposed method to be incorporated into the multicontinuum concept for solving nonlinear gas transport in a shale reservoir is presented. The present study provides a promising framework for real-field multiscale discrete-fracture models for unconventional-reservoir simulations.
The Impact of Ultraviolet Radiation on Barrier Function in Human Skin: Molecular Mechanisms and Topical Therapeutics
Authors: Alhasaniah Abdulaziz , Sherratt Michael J. , O'Neill Catherine A. 
Published: November 2018

A competent epidermal barrier is crucial for terrestrial mammals. This barrier must keep in water and prevent entry of noxious stimuli. Most importantly, the epidermis must also be a barrier to ultraviolet radiation (UVR) from the sunlight. Currently, the effects of ultraviolet radiation on epidermal barrier function are poorly understood. However, studies in mice and more limited work in humans suggest that the epidermal barrier becomes more permeable, as measured by increased transepidermal water loss, in response UVR, at doses sufficiently high to induce erythema. The mechanisms may include disturbance in the organisation of lipids in the stratum corneum (the outermost layer of the epidermis) and reduction in tight junction function in the granular layer (the first living layer of the skin). By contrast, suberythemal doses of UVR appear to have positive effects on epidermal barrier function.Topical sunscreens have direct and indirect protective effects on the barrier through their ability to block UV and also due to their moisturising or occlusive effects, which trap water in the skin, respectively. Some topical agents such as specific botanical extracts have been shown to prevent the loss of water associated with high doses of UVR.In this review, we discuss the current literature and suggest that the biology of UVR-induced barrier dysfunction, and the use of topical products to protect the barrier, are areas worthy of further investigation.
A New Schizophrenia Model: Immune Activation is Associated with the Induction of Different Neurotoxic Products which Together Determine Memory Impairments and Schizophrenia Symptom Dimensions
Authors: Sirivichayakul Sunee , Kanchanatawan Buranee , Thika Supaksorn , Carvalho André F. , Maes Michael 
Published: November 2018

Objective: Recently, we reported that stable-phase schizophrenia is characterized by two interrelated symptom dimensions: PHEMN (psychotic, hostility, excitation, mannerism and negative symptoms); and DAPS (depressive, anxiety and physio-somatic symptoms) and that Major Neuro-Cognitive psychosis (MNP) is the full-blown phenotype of schizophrenia (largely overlapping with deficit schizophrenia). Herein we examined the effects of immune activation in association with tryptophan catabolite (TRYCAT) patterning and memory disorders on PHEMN/DAPS dimensions and MNP.Methods:Serum levels of macrophage inflammatory protein-1 (MIP-1), soluble interleukin (IL)-1 receptor antagonist (sIL-1RA), IL-10, eotaxin, IgA/IgM responses to TRYCATs, and Consortium to Establish a Registry for Alzheimer’s disease (CERAD) tests were assessed in 40 controls and 80 schizophrenia patients.Results:Schizophrenia and MNP were predicted by significantly increased levels of IL-10, eotaxin and TRYCATs. A large part of variance in both PHEMN/DAPS symptom dimensions (42.8%) was explained by cytokine levels and TRYCATs combined. The MIP+sIL-1RA+IL-10 composite score and eotaxin explained each around on the basis of 19% of the variance in symptom dimensions, and approximately 18% of memory deficits. Moreover, MIP+sIL-1RA+IL-10 was significantly associated with elevations in picolinic acid, xanthurenic acid and 3-OH-kynurenine. Partial Least Squares path modeling shows that highly significant effects of MIP+sIL-1RA+IL-10 on symptomatology are mediated by the effects of noxious TRYCATs on memory deficits.Conclusion:Current findings indicate that in schizophrenia, immune activation may underpin activation of indoleamine-2,3-dioxygenase and kynurenine monooxygenase, while impairments in episodic and semantic memory may be caused by the neurotoxic effects of TRYCATs and eotaxin. The combined effects of immune activation, eotaxin and memory defects determine to a large extent, PHEMN/DAPS symptoms and the MNP phenotype. These findings indicate that schizophrenia phenomenology is largely mediated by multiple neuro-immune pathways and that immune activation, increased production of eotaxin and neurotoxic TRYCATs (picolinic acid, xanthurenic acid and 3-HOkynurenine) are new drug targets in schizophrenia and MNP.
Patents for the Physiological Quality in Seeds of Peach Rootstock Classified by Weight and Stored for Different Periods
Authors: Souza Aline G. , Smiderle Oscar J. , Menegatti Renata D. , de Lima Marcos Aurélio C. , das Neves Tainá R. , Bianchi Valmor J. 
Published: November 2018

Background:
Among stone fruit, the peach (Prunus persica (L) Batsch) is one of the
most widely grown species in Brazil, in both area cultivated and in production.

Objective:
The aim of this study was to evaluate the physiological quality of heavy and light seeds
of four cultivars of Prunus persica for two storage periods, from tests of electrical conductivity,
germination, and an analysis of initial plantlets growth.

Methods:
The Electrical Conductivity test (EC) was conducted in a Completely Randomised Design
(CRD), in a 4 x 2 x 5 factorial scheme with five replications. The germination test was carried
out in CRD, in a 4 x 2 factorial scheme with eight replications. The physiological quality of the
seeds was determined at zero and twelve month’s storage. For the growth analysis, the experimental
design was in CRD, in a 4 x 2 factorial scheme with four replications.

Results:
Under the conditions of the present study, it was found that the tests of germination and
electrical conductivity were complementary in evaluating physiological quality in seeds of Prunus
persica rootstock, suggesting that independent of the weight of the seeds, in ‘Capdeboscq’, ‘Aldrighi’,
‘Okinawa’ and ‘Okinawa Roxo’, there is a loss of quality and viability when the seeds are
stored for a period of 12 months.

Conclusion:
Under the experimental conditions of the present study, it was concluded that storage
for a period of 12 months in Recent patents is not rather recommendable for maintaining quality
and viability in seeds of Prunus persica of the Capdeboscq, Aldrighi, Okinawa and Okinawa Roxo
cultivars.
SINERGITAS ISLAMIC MICROFINANCE INSTITUTION (IMFI): Pemberdayaan dan Peningkatan Kesejahteraan Usaha Mikro Kecil dan Menengah (UMKM)
Authors: Suharti Fisit 
Published: November 2018

Dua dekade terakhir perkembangan ekonomi syariah ramai dengan munculnya berbagai lembaga keuangan syariah, termasuk di dalamnya adalah BMT dan lembaga zakat. Namun, lembaga zakat ini jauh lebih awal dibanding dengan BMT. Kedua lembaga ini memiliki kesamamaan dalam fungsi intermediary menghimpun dan menyalurkan dana ZIS dalam operasionalnya, tetapi di sisi lain keduanya juga memiliki sejumlah kendala, untuk itu dalam makalah ini penulis mencoba mensinergikan keduanya dalam rangka pemberdayaan masyarakat miskin dan peningkatan kesejahteraan Usaha Mikro Kecil dan Menengah (UMKM).
BMT memiliki potensi besar turut serta mewujudkan sektor UMKM yang kuat. Secara karakteristik, keberadaan lembaga keuangan ini memiliki kebersenyawaan yang erat dengan sektor usaha, karena target dan sasaran BMT serta skala usahanya memiliki orientasi pembiayaan sektor mikro. Selain itu aset nasional BMT juga telah mencapai Rp 4,7 trilliun, dengan jumlah pembiayaan Rp 3,6 trilliun. Sedangkan lembaga zakat dalam hal ini BAZNAS, juga memiliki potensi yang sama. Namun, dana ZIS ini nampaknya belum disalurkan secara maksimal. Efektivitas penyaluran dana ZIS tahun 2014 sekitar 67,50 % , sedangkan tahun 2015 ini hanya 26,91%.
Atas hal ini, perlu adanya sinergitas kedua lembaga ini dalam bentuk kerjasama penyaluran dana ZIS agar maksimal. BAZNAS memiliki dana ZIS yang cukup besar, dan BMT juga memiliki program pembiyaaan mikro dan dana ZIS. Mekanismenya adalah BAZNAS menyalurkan dana untuk mayarakat miskin dan pelaku usaha mikro (kecil dan menengah) melalui BMT agar lebih terkontrol. BMT dalam menyalurkan dana ZIS tersebut dengan mekanisme â€œACTORSâ€ melalui 5 tahapan, yakni, pemberian dana ZIS untuk masyarakat miskin, qardul , bagi hasil, return, saving.
â€œStudentâ€™s Passion on Entrepreneurship (Studi Pada Mahasiswa Fakultas Ekonomi dan Bisnis Islam, IAIN Purwokerto)
Authors: Socha Sochimin 
Published: November 2018

ABSTRACT
The aim of this study was to determine whether is minimum of one variables influence from personality, family environment, opportunities, and incomes towards entrepreneurship interest student of the Faculty of Economics and Business of Islam, IAIN Purwokerto. Data used in this research is primary data through questionnaire, interview, and observation. The sampling technique is Purposive Sampling which is calculated with Slovin formulaâ€™s. The data analysis by quantitative with multiple linear regression method using SPSS 17.0 for windows.
The result of this study shows that personal variable, famlily environment, opportunities, and incomes is take effect simultaneously on entrepreneurship interest student of the Faculty of Economics and Business of Islam, IAIN Purwokerto. Partially, personal variable, and opportunities isnâ€™t effect to entrepreneurhip interest student the Faculty of Economics and Business of Islam, IAIN Purwokerto, and family environment variable, and incomes is take effect to entrepreneurhip interest student the Faculty of Economics and Business of Islam, IAIN Purwokerto. The result of this reseach in a determination coefficient amont 0,79%, the mean is 79% variation entrepreneurship interest student the Faculty of Economics and Business of Islam, IAIN Purwokerto can be explain with independent variable which cover personality, family environment, opportunities, and incomes, and the rest explained by other varibles outside the regression model.
Keywords : Personality, Family Environment, Opportunities, Incomes, Entrepreneurship Interest, Entrepreneurship.