bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zum Umgang mit kritischen Ereignissen in der Balintgruppe – ein Werkstattbericht
Authors: Langewitz Wolf , Amann Michael , Emrich Manfred , Guillaumier Colette , Leggemann Hanne , Winkelmann Daniel 
Published: July 2018

ZusammenfassungEs wird über die Erfahrungen einer Leitergruppe berichtet, die an der letzten Balintwoche in Sils (www.sils-balintwoche.ch) mithilfe von Critical Incident Protokollen (CIP) über konkrete Erfahrungen mit Leiterinterventionen diskutiert hat. Dabei ging es um Momente, in denen Interventionen der Leitung als kritisch erlebt oder vermisst wurden. In den CIP wurden Situationen beschrieben, die den Teilnehmenden in lebhafter Erinnerung geblieben waren, entweder als Leiter einer Gruppe oder als ‚Geleiteter‘. In einem ersten Analyseschritt liessen sich die wesentlichen Probleme in der Leitung der Anfangsphase einer Gruppenarbeit (Fallvorstellung und erste Reaktionen der Teilnehmer) und dem Mittelteil (Arbeiten mit den Assoziationen und Kommentaren der Gruppenmitglieder) zuordnen. Im nächsten Schritt wurden mögliche Leiterinterventionen im Rollenspiel erprobt. Als wesentliches Charakteristikum der Balintarbeit wurde der Umgang mit nicht deterministischem Material, das sich nicht ohne Weiteres kategorial einordnen lässt, herausgearbeitet. Der Leiter hat daher die Aufgabe, vorzeitigen Festlegungen und Interpretationen entgegenzuwirken. Dazu gehört, zunächst und sorgfältig Wahrnehmungen am eigenen Leib entgegenzunehmen (z. B. Kältegefühl, Schwere, Wunsch, tief Luft zu holen), bevor diese in eigentliche Gefühle (z. B. Angst, Trauer) ‚übersetzt‘ und diese dann einzelnen Personen zugeschrieben werden. Hilfreiche Leiterinterventionen stammen aus dem Repertoire einer Gesprächsführung, die den diskursiven Raum offenhält (z. B. Spiegeln, Reflecting Back). Der richtige Zeitpunkt für Leiterinterventionen wurde als ein Moment der Überraschung identifiziert, wenn ein Votum etwas völlig Neues anspricht oder wenn ein widersprüchliches Votum im Gruppenprozess untergeht. Theoretisch einordnen liess sich die Auseinandersetzung mit dem Vagen und Unbestimmten und dennoch unendlich Reichen am ehesten mit dem Begriff der Situation aus der Neuen Phänomenologie, die vom Philosophen Hermann Schmitz entwickelt wurde
Transient surface ocean oxygenation recorded in the ∼2.66-Ga Jeerinah Formation, Australia
Authors: Koehler Matthew C. , Buick Roger , Kipp Michael A. , Stüeken Eva E. , Zaloumis Jonathan 
Published: July 2018

SignificanceUnderstanding how and when Earth’s surface became oxygenated is essential for understanding its biogeochemical evolution. Incipient oxygenation of Earth’s surface environments before the Great Oxidation Event (GOE; ∼2.4 Ga) has been well-documented, but the nature of these redox changes, whether protracted or transient, is poorly understood. We present nitrogen isotope ratios, selenium abundances, and selenium isotope ratios from the Jeerinah Formation (∼2.66 Ga; Fortescue Group, Western Australia) that represent (i) high-resolution evidence of transient surface ocean oxygenation ∼260 My before the GOE, (ii) a possible muted pulse of oxidative continental weathering, and (iii) the oldest firm evidence for nitrification and denitrification metabolisms. These results, in concert with previous studies, highlight the variability in mechanisms and magnitudes of Neoarchean oxygen fluctuations.
Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2
Authors: Banerjee Sourav , Ji Chenggong , Mayfield Joshua E. , Goel Apollina , Xiao Junyu , Dixon Jack E. , Guo Xing 
Published: July 2018

Significance
Curcumin is an ancient drug derived from turmeric and has been found to exhibit potent anticancer properties albeit through controversial mechanisms of action. Using a biochemical model, mouse cancer model, and cellular models, we show that curcumin is a highly potent and selective inhibitor of dual-specificity tyrosine-regulated kinase 2 (DYRK2), a positive regulator of the 26S proteasome. Curcumin perturbs 26S proteasome activity via DYRK2 inhibition in various cancer cells and in the mouse cancer model leading to impairment of cell proliferation and reduction of cancer burden in mice. This novel mechanism of action of curcumin opens up new avenues for potential preventative or therapeutic strategies in proteasome-addicted cancers like triple-negative breast cancer and multiple myeloma.
Between invisibility and over-visibility
Authors: Zheng Binghan , Xiang Xia 
Published: July 2018

Abstract
Recent research on liaison interpreting shows that the interpreters’ role in communicative events includes language facilitator and
intercultural mediator. Being empowered with more coordinating functions rather than regarded as invisible conduits, however, how
do interpreters with different professional experiences perceive their own role in business settings? And what are the actual
expectations on them from their clients? This paper tries to answer the questions through a questionnaire-based survey of three
groups of respondents: professional interpreters, student interpreters and clients, with each group including 30 respondents.
Chesterman’s (2001) four models of ethics, together with the hypothetical no ethics
model, were designed as answers to the questionnaire (17 closed questions) and translation versions to two interpreting samples.
The frequencies of responses to the questions and the evaluation scores of the translation versions are collected and analyzed,
revealing the following findings: All three groups acknowledge the constraints translation ethics place on the freedom of action;
and all three groups agree that interpreters simultaneously shoulder the tasks of translating and coordinating, with the “ethics
of communication” being the most widely acknowledged one. However, there are discrepancies between and within the groups, and even
attitudinal inconsistencies and contradictions in individual participants. These findings, by re-describing the interpreter’s
power in interlingual and intercultural interactions, will help improve professional standards and interpreting training.
Evolutionary Phonology and the life cycle of voiceless
sonorants
Authors: Blevins Juliette 
Published: July 2018

Abstract
In this chapter I examine the phonetic origins of voiceless
sonorants cross-linguistically within the general framework of
Evolutionary Phonology (Blevins
2004; 2006;
2008b; 2015). In terms of a general
hierarchy of contrast, we observe that: voiceless obstruents are
common; voiceless sonorant consonants are uncommon; voiceless vowels
are extremely rare. One phonetic source of voiceless sonorants
is coarticulation in RH and HR and clusters, where R is a sonorant
and H is a segment produced with a spread glottal gesture. Voiceless
sonorants may also arise when laryngeal spreading gestures are
associated with prosodic domains. In this second case, voiceless
sonorants can arise as allophones of their voiced counterparts.
While a fair number of languages show voiceless sonorant glides,
liquids and nasals phonologized as a consequence of RH/HR
coarticulation, voiceless vowels resist phonologization despite
their high frequency as phonetic variants of modal vowels. In
some cases, voiceless vowels are lost before phonologization can
occur. In other cases, resistance to phonologization may be due to
effects of analogy, /h/, word phonotactics, or lexical
competition.
From ergative case-marking to hierarchical agreement
Authors: Guillaume Antoine 
Published: July 2018

Abstract
This paper reconstructs the history of a set of innovated 1st and 2nd
person verbal prefixes in Reyesano which manifest the phenomenon of
‘hierarchical agreement’ in transitive clauses, according to a
2>1>3 hierarchy. I argue that these prefixes come from
independent ergative-absolutive pronouns which first became
case-neutral enclitics in 2nd position in main clauses and then verb
prefixes. And I show that the hierarchical effects that the prefixes
manifest in synchrony have nothing to do with the working of a
hierarchy during the grammaticalization process. In doing so, the
paper contributes to the growing body of diachronic evidence against
the idea that the person hierarchy is a universal of human language
reflecting a more general principal of human cognition.
Adding omega‐3 fatty acids to a protein‐based supplement during pre‐season training results in reduced muscle soreness and the better maintenance of explosive power in professional Rugby Union players
Authors: Black Katherine Elizabeth , Witard Oliver C. , Baker Dane , Healey Philip , Lewis Victoria , Tavares Francisco , Christensen Sam , Pease Tom , Smith Brett 
Published: July 2018

AbstractEvidence suggests that omega‐3 fatty acid supplementation could reduce muscle soreness and maintain muscle function following eccentric exercise‐induced muscle damage. The aim of this applied field study was to investigate the effectiveness of consuming a protein‐based supplement containing 1546 mg of omega‐3 polyunsaturated fatty acid (PUFA) (551 mg eicosapentaenoic acid (EPA) and 551 mg docosahexaenoic acid (DHA)) twice daily (FO) compared to a protein‐based placebo (P) on muscle soreness, countermovement jump (CMJ) performance and psychological well‐being in 20 professional Rugby Union players during 5 weeks of pre‐season training. Players completed a 5‐point‐Likert soreness scale with 5 indicating “no soreness” and a questionnaire assessing fatigue, sleep, stress and mood each morning of training, plus they performed CMJ tests once or twice per week. Data were analysed using magnitude‐based inferential statistics and are presented as percent beneficial/trivial/harmful. On day 35, there was a likely (% beneficial/trivial/harmful: 94/5/1) moderate (0.75, standardized mean difference (SMD)) beneficial effect of FO vs. P on the change in lower body muscle soreness compared with day 0 (FO: −3.8 ± 21.7%; P: −19.4 ± 11.2%). There was a likely (92/7/0) moderate (SMD: 0.60) beneficial effect of FO vs. P on CMJ performance (change from baseline to day 35, FO: +4.6 ± 5.9%; P: −3.4 ± 8.6%). From day 20, a moderate beneficial effect of FO on fatigue was observed. In terms of practical relevance, the moderate beneficial effect of adding fish oil to a protein‐based supplement on muscle soreness translated into the better maintenance of explosive power in elite Rugby Union players during pre‐season training.
Care Home Life and Identity: A Qualitative Case Study
Authors: Paddock Katie , Brown Wilson Christine , Walshe Catherine , Todd Chris 
Published: July 2018

AbstractBackground and ObjectivesThe transition to a care home can involve multiple changes and losses that can affect an older person’s well-being and identity. It is not clear how older people perceive and manage their identity within a care home over time. This study explores how living in a care home affects the identities of residents and how they address this in their daily lives.Research Design and MethodsA multiple qualitative case study approach incorporated interview and observational data. Eighteen semistructured interviews and 260 hr of observations were conducted over 1 year with care home residents, relatives, and staff across three care homes within Greater Manchester, UK. Data were analyzed using framework analysis, drawing on the social identity perspective as an interpretive lens.ResultsFour themes were identified: (a) changing with age, (b) independence and autonomy, (c) bounded identity, and (d) social comparison. The impact of aging that initially altered residents’ identities was exacerbated by the care home environment. Institutional restrictions jeopardized independence and autonomy, provoking residents to redefine this within the allowances of the care home. Strict routines and resource constraints of well-meaning staff resulted in the bounded expression of personalities. Consequently, to forge a positive identity, residents without dementia engaged in social comparison with residents with dementia, emphasizing their superior cognitive and physical abilities.Discussion and ImplicationsSocial comparison as an adaptive strategy has previously been unidentified in care home literature. Residents need more support to express their identities, which may reduce the necessity of social comparison, and improve interrelationships and well-being.
Failures in reproductive health policy: overcoming the consequences and causes of inaction
Authors: Sher Jonathan , Frank John W , Doi Lawrence , de Caestecker Linda 
Published: July 2018

Abstract
It is assumed that long-established research findings and internationally accepted evidence should, and will, be translated into policy and practice. Knowledge about what prevents harm and promotes health has, in fact, guided and resulted in numerous beneficial public health actions. However, such is not always the case. The authors examine three notable, and unwelcome, exceptions in the UK—all in the field of reproductive health and all focused on the period prior to pregnancy. The three examples of counterproductive inaction discussed are: fortifying flour with Vitamin B9 (folic acid); preventing foetal alcohol spectrum disorders; and reducing risks and better regulating a highly teratogenic medication (valproate). The adverse consequences, as well as the causes, of inaction are analysed for each example. Reasons for optimism, and recommendations for overcoming inaction, are also offered, in particular, greater priority should be accorded to preconception health, education and care.
Aquatic caddisworm silk is solidified by environmental metal ions during the natural fiber‐spinning process
Authors: Ashton Nicholas N. , Stewart Russell J. 
Published: July 2018

ABSTRACTAquatic caddisfly larvae (caddisworms) wet‐spin fibers to construct composite cases of silk and stone. The silk emerges from labial ducts as a nanofibrous fluid gel, flowing over the stone substrate and making intimate interfacial adhesive contacts before being drawn into tough fibers that rapidly solidify underwater to span gaps in the construction. Divalent metal ions are responsible for the unique mechanical properties of naturally spun silk fibers; however, when and where divalent metal ions are incorporated into the metallofibers and other aspects of the fiber solidification mechanism are poorly understood. To investigate, the elemental composition and secondary structure of silk precursors stored in the silk gland lumen were compared with naturally spun fibers by inductively coupled plasma optical emission spectroscopy and attenuated total reflection Fourier transform infrared spectroscopy. Naturally spun fibers contained near equimolar ratios of Ca2+ to P. In contrast, silk precursors stored in the silk gland lumen contained only traces of Ca2+ and other multivalent metal ions. Ca2+ was also undetectable in anterior lumenal silk using the histochemical Ca2+ indicator, alizarin S red. Addition of Ca2+ to isolated lumenal silk resulted in Ca2+ complexation by H‐fibroin phosphoserines (pSs) and a shift in secondary structure from random coils to β‐structures, creating infrared spectra in the phosphate and amide I regions nearly equivalent to those found in naturally spun Ca2+‐containing silk fibers. Light and electron microscopy within distinct regions of the silk gland suggested that posterior gland silk colloidal complexes transition into a nanofibrous morphology as they pass into the chitin‐lined anterior lumen. Altogether, the results suggest that environmental Ca2+ absorbed from natural water triggers silk fiber solidification postdraw by complexing H‐fibroin pSs, creating Ca2+‐stabilized crystalline β‐nanodomains that cross‐link and toughen the freshly drawn silk fibers.—Ashton, N. N., Stewart, R. J. Aquatic caddisworm silk is solidified by environmental metal ions during the natural fiber‐spinning process. FASEB J. 33, 572–583 (2019). www.fasebj.org
Quantitative Apparent Diffusion Coefficient Derived From Diffusion-Weighted Imaging Has the Potential to Avoid Unnecessary MRI-Guided Biopsies of mpMRI-Detected PI-RADS 4 and 5 Lesions
Authors: Polanec Stephan H. , Helbich Thomas H. , Bickel Hubert , Wengert Georg J. , Pinker Katja , Spick Claudio , Clauser Paola , Susani Martin , Shariat Shahrokh , Baltzer Pascal A.T. 
Published: July 2018

Objective
The aim of this study was to evaluate the potential of diffusion-weighted imaging–derived apparent diffusion coefficient (ADC) measurements to obviate unnecessary biopsies in multiparametric MRI–detected PI-RADS 4 and 5 lesions.

Materials and Methods
This retrospective, institutional review board–approved study investigated 101 PI-RADS 4 and 5 prostate lesions (52 malignant, 49 benign) verified by in-bore MRI-guided biopsy in 101 men (mean age, 62.8 years). Two readers, who were not aware of the biopsy results independently and repeatedly measured minimum, mean, and maximum ADC from diffusion-weighted imaging measurements (in line with PI-RADS v2 recommendations) using a 2-dimensional region of interest drawn around the biopsied lesions. Diagnostic performance was evaluated using receiver operating characteristic statistics and reproducibility statistics were calculated.

Results
The best diagnostic performance (overall area under the receiver operating characteristic curve [AUC] R1: 0.801; R2: 0.796 peripheral zone AUC R1:0.814, R2: 0.805; transitional zone AUC R1:0.786, R2:0.779) and the tightest limits of interreader agreement (−8.6% to 9.9%) were found in minimum ADC values. Rule-in and rule-out thresholds for diagnosis of prostate cancer were identified, demonstrating a potential to avoid unnecessary biopsies in 32.7% (16/49).

Conclusions
Quantitative ADC measurement in multiparametric MRI–detected PI-RADS 4 and 5 lesions has the potential to avoid unnecessary MRI-guided biopsies in up to 33%.
On the use of wavelets to reveal oscillatory patterns in stellar flare emission
Authors: López-Santiago J. 
Published: July 2018

Wavelet analysis is a powerful tool to investigate non-stationary signals such as amplitude modulated sinusoids or single events lasting for a small percentage of the observing time. Wavelet analysis can be used, for example, to reveal oscillations in the light curve of stars during coronal flares. A careful treatment of the background in the wavelet scalogram is necessary to determine robust confidence levels required to distinguish between patterns caused by actual oscillations and noise. This work describes the method using synthetic light curves and investigates the effect of background noise when determining confidence levels in the scalogram. The result of this analysis shows that the wavelet transform is able to reveal oscillatory patterns even when frequency-dependent noise is dominant. However, their significance in the wavelet scalogram may be reduced, depending on the assumed background spectrum. To show the power of wavelet analysis, the light curve of a well-known flaring star is analysed. It shows two oscillations overlapped. The lower-frequency oscillation is not mentioned in previous works in the literature. This result demonstrates the need for correctly characterizing the background noise of the signal.
This article is part of the theme issue ‘Redundancy rules: the continuous wavelet transform comes of age’.
Nonlinear analysis of natural folds using wavelet transforms and recurrence plots
Authors: Ord Alison , Hobbs Bruce , Dering Greg , Gessner Klaus 
Published: July 2018

Three-dimensional models of natural geological fold systems established by photogrammetry are quantified in order to constrain the processes responsible for their formation. The folds are treated as nonlinear dynamical systems and the quantification is based on the two features that characterize such systems, namely their multifractal geometry and recurrence quantification. The multifractal spectrum is established using wavelet transforms and the wavelet transform modulus maxima method, the generalized fractal or Renyi dimensions and the Hurst exponents for longitudinal and orthogonal sections of the folds. Recurrence is established through recurrence quantification analysis (RQA). We not only examine natural folds but also compare their signals with synthetic signals comprising periodic patterns with superimposed noise, and quasi-periodic and chaotic signals. These results indicate that the natural fold systems analysed resemble periodic signals with superimposed chaotic signals consistent with the nonlinear dynamical theory of folding. Prediction based on nonlinear dynamics, in this case through RQA, takes into account the full mechanics of the formation of the geological system.This article is part of the theme issue ‘Redundancy rules: the continuous wavelet transform comes of age’.
The Stress-Chip: A microfluidic platform for stress analysis inCaenorhabditis elegans
Authors: Banse Stephen A. , Blue Benjamin W. , Robinson Kristin J. , Jarrett Cody M. , Phillips Patrick C. 
Published: July 2018

AbstractAn organism’s ability to mount a physiological response to external stressors is fundamental to its interaction with the environment. Experimental exploration of these interactions benefits greatly from the ability to maintain tight control of the environment, even under conditions in which it would be normal for the subject to flee the stressor. ere we present a nematode research platform that pairs automated image acquisition and analysis with a custom microfluidic device. This platform enables tight environmental control in low-density, single-worm arenas, which preclude animal escape while still allowing a broad range of behavioral activities. The platform is easily scalable, with two 50 arena arrays per chip and an imaging capacity of 600 animals per scanning device. Validating the device using dietary, osmotic, and oxidative stress indicates that it should be of broad use as a research platform, including eventual adaptation for additional stressors, anthelmintic-drug screening, and toxicology studies.
Optical and physical mapping with local finishing enables megabase-scale resolution of agronomically important regions in the wheat genome
Authors: Keeble-Gagnère G. , Rigault P. , Tibbits J. , Pasam R. , Hayden M. , Forrest K. , Frenkel Z. , Korol A. , Huang E. , Cavanagh C. , Taylor J. , Abrouk M. , Sharpe A. , Konkin D. , Sourdille P. , Darrier B. , Choulet F. , Bernard A. , Rochfort S. , Dimech AM. , Watson-Haigh N. , Baumann U. , Eckermann P. , Fleury D. , Juhasz A. , Boisvert S. , Nolin M-A. , Doležel J. , Šimková H. , Toegelová H. , Šafář Jan , Luo M-C. , Camara F. , Pfeifer M. , Isdale D. , Nystrom-Persson J. ,   IWGSC, Koo D-H , Tinning M. , Cui D. , Ru Z. , Appels R. 
Published: July 2018

AbstractBackgroundNumerous scaffold-level sequences for wheat are now being released and, in this context, we report on a strategy for improving the overall assembly to a level comparable to that of the human genome.ResultsUsing chromosome 7A of wheat as a model, sequence-finished megabase scale sections of this chromosome were established by combining a new independent assembly based on a BAC-based physical map, BAC pool paired end sequencing, chromosome arm specific mate-pair sequencing and Bionano optical mapping with the IWGSC RefSeq v1.0 sequence and its underlying raw data. The combined assembly results in 18 super-scaffolds across the chromosome. The value of finished genome regions is demonstrated for two approximately 2.5 Mb regions associated with yield and the grain quality phenotype of fructan carbohydrate grain levels. In addition, the 50 Mb centromere region analysis incorporates cytological data highlighting the importance of non-sequence data in the assembly of this complex genome region.ConclusionsSufficient genome sequence information is shown to be now available for the wheat community to produce sequence-finished releases of each chromosome of the reference genome. The high-level completion identified that an array of seven fructosyl transferase genes underpins grain quality and yield attributes are affected by five f-box-only-protein-ubiquitin ligase domain and four root-specific lipid transfer domain genes. The completed sequence also includes the centromere.