bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico Prediction of Inhibitory Constant of Thrombin Inhibitors Using Machine Learning
Authors: Zhao Junnan , Zhu Lu , Zhou Weineng , Yin Lingfeng , Wang Yuchen , Fan Yuanrong , Chen Yadong , Liu Haichun 
Published: December 2018

Background:
Thrombin is the central protease of the vertebrate blood coagulation
cascade, which is closely related to cardiovascular diseases. The inhibitory constant Ki is the most
significant property of thrombin inhibitors.

Method:
This study was carried out to predict Ki values of thrombin inhibitors based on a large data
set by using machine learning methods. Taking advantage of finding non-intuitive regularities on
high-dimensional datasets, machine learning can be used to build effective predictive models. A total
of 6554 descriptors for each compound were collected and an efficient descriptor selection method
was chosen to find the appropriate descriptors. Four different methods including multiple linear
regression (MLR), K Nearest Neighbors (KNN), Gradient Boosting Regression Tree (GBRT) and
Support Vector Machine (SVM) were implemented to build prediction models with these selected
descriptors.

Results:
The SVM model was the best one among these methods with R2=0.84, MSE=0.55 for the
training set and R2=0.83, MSE=0.56 for the test set. Several validation methods such as yrandomization
test and applicability domain evaluation, were adopted to assess the robustness and
generalization ability of the model. The final model shows excellent stability and predictive ability
and can be employed for rapid estimation of the inhibitory constant, which is full of help for
designing novel thrombin inhibitors.
Outcomes of Treatment and Predictors of Response to Sofosbuvir Plus Simeprevir in Hepatitis C Virus with Genotype-4 Infection
Authors: Ahmed Ossama A. , Elsebaey Mohamed A , Fouad Mohamed Hassan A. , Elkadeem Mahmoud , Badawi Rehab , Khayyal Ahmed , Soliman Shaimaa , Negm Manal Saad , Abd-Elsalam Sherief 
Published: December 2018

Background & Aims:
Treatment plan of chronic HCV infection has dramatically improved
after the introduction of different groups of Direct-Acting Antiviral (DAA) drugs. These
drugs have been found to be safe and effective. Sofosbuvir (SOF) plus simeprevir (SMV) regimen
has been shown to be tolerable and effective in treatment of patients with HCV genotype 1. The
aim of the study was to evaluate the safety and the efficacy of combined sofosbuvir plus simeprevir
treatment in genotype 4 chronic HCV patients.

Methods:
This open-label multicenter prospective study was carried out on 381 Egyptian patients
with chronic hepatitis C virus- infection. Treatment experienced and treatment-naive patients were
included. Subjects administrated a regimen of sofosbuvir (400 mg/ day) plus semiprevir (150 mg
/day) for twelve weeks. Sustained Virological Response (SVR) was confirmed by undetectable
HCV RNA by quantitative PCR 3 months after the end of the treatment.

Results:
97.6% (372 /381) of patients had SVR. None of the studied clinical and demographic
characteristics were associated with the SVR status. However, patients who failed to achieve SVR
showed low albumin level and high total leucocyte. The most common side effects of the studied
regimen were headache, fatigue, itching, photosensitivity, and cough.

Conclusion:
Twelve weeks’ regimen of sofosbuvir plus simeprevir was considered to be safe and
tolerable in the treatment of HCV genotype 4; also it was associated with high SVR (97.6%).
Biomarkers of Oxidative Stress and Inflammation in Chagasic Myocardiopathy
Authors: Gabriela Gerrard , Belén Martí M. , Romina Diviani , Jose Ceruti M. , Susana Lioi , Juan Beloscar , Mabel D´Arrigo 
Published: December 2018

Introduction:The fact that only part of the population that lives in endemic areas gets Chagas disease and that only some of the patients with chronic infection develop symptoms, supports the importance of investigating the factors of each host in the susceptibility and the development of the disease. Chronic pathological processes and progressive inflammation lead to alterations in the cellular antioxidant status. This imbalance would contribute to the destruction of the parasite and would be related to the cardiac damage observed in patients with chagasic cardiomyopathy.Objective:The objective of the present study was to determine the plasma activity of oxidative stress and inflammatory biomarkers: SOD, CAT, GPx, TBARS and TNF-α in chagasic patients with and without cardiomyopathy and healthy individuals.Aim:The aim of the present study is to demonstrate the predisposition to severe forms of chagasic heart disease by quantifying the biomarkers mentioned in blood from the study population.Results and Conclusion:The results show significant differences in the enzymatic activities in the different groups of patients, which would mean at the cellular level, an alteration of the antioxidant capacity. Contrary to what we expected (a depletion of these enzymes), patients show an increase in antioxidant activity, that is, they respond to the generation of free radicals. The same trend is observed in the case of TBARS that are elevated in the case of chagasic patients, indicating a high degree of lipid peroxidation and oxidative damage. Regarding TNF-α levels, we found statistically significant differences, which show an active and chronic inflammatory state in these patients. Although we have found significant differences between the CN group and the other groups of patients, we should indicate that between the MCC and ECsinMCC groups, the results obtained did not show marked differences. This is important since it has been shown that patients infected with Tc have a marked antioxidant potential and are able to respond to the oxidative stress induced by the parasite, although this would not be decisive in the evolution of the disease.
Induction of S-phase Cell Cycle Arrest and Apoptosis in HeLa Cells by Small RNAs Fraction ofSolanum tuberosumL.
Authors: Yadav Sunny , Jahagirdar Devashree , Shekhawat Mamta , Sharma Nilesh Kumar 
Published: December 2018

Background:In cancer therapeutics, several new classes of small molecules based targeted drug options are reported including peptide mimetic and small RNAs therapeutics.Objective:Small RNAs represent a class of short non-coding endogenous RNAs that play an important role in transcriptional and post transcriptional gene regulation among varied types of species including plants and animals.Methods:To address the role of small RNAs from plant sources upon cancer cells, authors report on the effects of small RNAs fraction of potato in in-vitro model of human derived HeLa cancer cells. This paper reports the anti-proliferative and anti-survival effect of small RNAs fraction of S. tuberosum L. (potato) tuber tissue. Here, authors employed small RNAs fractionation protocol, cell viability, cell cytotoxicity MTT, PI stained cell cycle analysis and FITC-Annexin-V/PI stained apoptosis assays.Results:In this paper, small RNAs fractions of potato clearly indicate 40-50% inhibition of HeLa cell proliferation and viability. Interestingly, flow cytometer data point out appreciable increase from 7% to 14% of S-phase in HeLa cells by displaying the presence of an S-phase cell cycle arrest. Further, arrest in S-phase of HeLa cells is also supported by an appreciable increase in total <2N plus >4N DNA containing HeLa cells over 2N containing HeLa cells. For apoptotic assay, data suggest a significant increase in apoptotic HeLa cells from (5%) control treated HeLa cells to (18%) small RNAs treated HeLa cells.Conclusion:Taken together, findings suggest that small RNAs fractions of potato can induce Sphase cell cycle arrest and these agents can act as an anti-proliferative agent in HeLa cells. This paper proposes a huge scope for novel finding to dissect out the small RNAs target within HeLa cells and other cancer cell types.
Влияние изовалентного замещения катионов на термические, калорические и магнетокалорические свойства манганитов (La-=SUB=-1-y-=/SUB=-Eu-=SUB=-y-=/SUB=-)-=SUB=-0.7-=/SUB=-Pb-=SUB=-0.3-=/SUB=-MnO-=SUB=-3-=/SUB=-
Authors: Карташев А.В. , Флёров И.Н. , Горев М.В. , Михашенок Н.В. 
Published: December 2018

AbstractCrystalline samples of the (La_1 – _ y Eu_ y )_0.7Pb_0.3MnO_3 ( y = 0, 0.2, 0.4, 0.5, 0.6, and 0.8) manganite solid solutions have been grown. Temperature dependences of the specific heat, thermal expansion, and high-intensity magnetocaloric effect have been investigated. A comparative analysis of the effect of isovalent cationic substitution on the thermal and caloric parameters of the ferromagnetic phase transition has been made. It has been shown that the growth of the Eu atom concentration leads to a decrease in the phase transition entropy and an increase in the baric coefficient dT / dp . Field and temperature dependences of the magnetocaloric effect have been established. It is demonstrated that, varying the ratio of cations, one can obtain the solid solutions with the maximum magnetocaloric effect value in fields of up to 6 kOe in a temperature range of 90–340 K. Owing to the similar reduced relative cooling powers, the investigated solid solutions can be used as reference solid-state cooling media in designing the cascade cooling systems.
Half-metallic characteristic in the new full-Heusler SrYO-=SUB=-2-=/SUB=- (Y = Sc, Ti, V and Cr) -=SUP=-*-=/SUP=-
Authors: Nazemi N. , Ahmadian F. 
Published: December 2018

AbstractHalf-metallic properties of SrYO_2 (Y = Sc, Ti, V, and Cr) full-Hensler compounds were studied using full-potential linearized augmented plane wave method based on density functional theory. The negative formation energies of SrYO_2 (Y = Sc, Ti, V, and Cr) alloys confirmed that they can be synthesized experimentally. Total energy calculations showed that AlCu_2Mn-type structure was the ground state structure in all compounds. In both structures, SrYO_2 (Y = Ti, V, and Cr) alloys were half-metallic ferrromagnets, while SrScO_2 was a non- magnetic metal. The origin of half-metallicity was verified for SrCrO_2. SrYO_2 (Y = Ti, V, and Cr) alloys in both structures were half-metals in a wide range of lattice constants indicating that they are quite robust against hydrostatic strains. The magnetization of SrYO_2 (Y = Ti, V, and Cr) alloys was mainly originated from the 3 d electrons of Y (= Ti, V, and Cr) atoms and followed the Slater–Pauling rule: M _tot = Z _tot – 12. Generally, It is expected that SrYO_2 (Y = Ti, V, and Cr) alloys are promising and interesting candidates in the future spintronic field.
Effect of Porphyromonas gingivalis infection on leukocyte count in rat model of diabetes mellitus
Authors: Ulfita Safira Niza , Dharmayanti Agustin Wulan Suci , Yuwono Budi 
Published: December 2018

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and become the third cause of death in Indonesia. The most common oral complications occured in DM is periodontitis. Porphyromonas gingivalis (Pg) is the main etiology of periodontitis, one of periodonthopathogen relate to systemic disease. However this theory still controversial, DM and periodontitis have the same pathogenesis, thus are cellular changes. Pg is predicted affect the total leukocytes count in DM. The aim of this study was to determine the effect of Pg infection to total leukocytes count in DM rat model. The rat model of DM was obtained by injection of streptozotocin with different dosage for 5 days sequentially then injected by Pg on distobuccal and distopalatal sulcus of the maxillary first molars for 19 days with interval 3 days. The total leukocytes were calculated manually by Neubauer improved cell counting chamber. The results demonstrated that rat model of DM which injected by Pg has the lowest total leukocytes count. Therefore, Pg infection decreased the total leukocytesin DM rat model.
Berebut Ruang Publik Sekolah Pasca Orde Baru: Studi Kasus Pertarungan Politik Ideologi di Kerohanian Islam (ROHIS)
Authors: Aidulsyah Fachri 
Published: December 2018

The Burgeoning of the Islamic Movements in Indonesia –especially originated from the Middle East- that growing up since authoritarian era have been influencing various institutions in Indonesia, including educational institution in Ex Karesidenan Surakarta region. In this research, I exhibit that Ex-Karesidenan Surakarta region has become a centre of Islamic movement turbulence in Indonesia. Since pre-Independence era, various Islamic ideologies actualize and compete with each other –from traditionalist, modernist, and radical movement- for gaining influence in these regions. This research discusses the implication of contestation among Islamic ideologies in Senior High School that affect the scramble of educational public sphere and interchange cultural symbols in these institutions. This paper attempts to address two main issues; 1) to examine various contestation and hegemony models performed by each of Islamic ideologies for gaining influence in the public educational sphere –epecially Kerohanian Islam (ROHIS); 2) to explore various political ideologies in each Islamic movement that led to different meanings towards Islam, state, and democracy.
Youth Within Transition: Recent Developments in Education and Employment in Yogyakarta
Authors: Tjahjadi Alexander Michael , Widhyharto Derajad Sulistyo 
Published: December 2018

Yogyakarta as a parameter for the development of national education offers potential young and educated human resources. It is hoped that this potential will trigger youth’s productivity to contribute in the demographic bonus and national development. From the perspective of economic growth, Yogyakarta tends to have an increasing trend when compared to that of national economy which tends to decline. However, the increasing trend can become a problem when the educated youth are unproductive and fails to transition from education field to working field. The data of Yogyakarta’s GDRP from 2003 to 2013 shows a dependency on the trading, tourism and services sectors. Optimism towards those three sectors do show a percentage increase, but it is not in sync with the education potential and employment for the youth. There is a transition from young labour who are self- or family-employed into low-rank employees and paid labor. There are at least two effects of this phenomenon. First, the data shows that the number of unemployed youth become stagnant with high school as the highest completed education. This indicates a hindrance for transition among youth from secondary education to higher education. Second, this obstacle prevents youth from moving into a higher income bracket and traps them in below-average wages. In reality, economic growth is still reliant on the services and consumption sectors, thus a transitory approach is needed that can involve the youth not as an object but as a main feature of Special Region of Yogyakarta is needed.
Tavallista sujumattomuutta: Aikuisten puheen sujuvuuden kvantitatiivinen analyysi
Authors: Penttilä Nelly , Korpijaakko-Huuhka Anna-Maija , Kent Raymond D. 
Published: December 2018

Tutkimus käsittelee suomenkielisten aikuisten puheen tyypillisiä sujumattomuuksia ja niiden normaalivariaatiota. Henkilöt (N = 70) olivat neurologisesti terveitä, eikä heillä ollut diagnosoituja puheen tai kielen häiriöitä. Heidän sarjakuvakerrontaan perustuvien audioaineistojen transkriptioista analysoitiin puhenopeuden ja artikulaationopeuden lisäksi 10 puheen sujuvuutta kuvaavaa muuttujaa. Tutkimuksessa tarkasteltiin muuttujien yleisyyttä, niiden keskinäisiä suhteita sekä sujumattomuuksien vaikutusta sujumattomuusprosenttiin. Sujumattomuusprosentin keskiarvo oli koko aineistossa 2,3 % (vv = 0,0–7,8 %), ja sitä selittivät vahvimmin muuttujat korjaus ja sanan toisto sekä epäröinti, joka oli myös yleisin sujumattomuustyyppi. Sujumattomuusprosentin mukaan jaetuissa puhujaryhmissä sujumattomuuden tyyppi muuttui sujumattomuusprosentin kasvaessa. Sujumattomuuksista muodostui neljä faktoria: sujumattomuudet, jotka liittyivät 1) kielelliseen muotoiluun, 2) viestin suunnitteluun, 3) viestin jatkuvuuden ylläpitoon ja 4) artikulaatioon. Sujumattomuusprosenttia selittivät parhaiten sujumattomuudet, jotka liittyivät kielelliseen muotoiluun sekä ilmaisun jatkuvuuden ylläpitoon. Tulokset vahvistivat ajatusta puheen sujuvuudesta jatkumona sekä toivat esiin sujumattomuuksien laajan variaation niin määrällisesti kuin laadullisestikin. Tämän aineiston normaalivariaatiota voidaan käyttää sekä häiriödiagnostiikan että kuntoutustavoitteiden asettamisen tukena. Lisäksi tutkimuksen tulokset toimivat vertailupohjana tuleville tutkimuksille.
KÜRESELLEŞME SÜRECİNDE ÇOK ULUSLU ŞİRKETLERİN EKONOMİK AÇIDAN DEĞERLENDİRİLMESİ
Authors: KAMACI Ahmet 
Published: December 2018

1980’den sonra
dünya ekonomisinde neoliberal politikalar ekseninde yaşanan değişim ve dönüşüm
süreci küreselleşme olarak tanımlanmaktadır. Küreselleşme, siyasi, ekonomik ve sosyo-kültürel boyutları içeren önemli
bir süreci ifade etmektedir. Küreselleşme sürecinde çok uluslu şirketler ise,
belli miktarda sermaye ve satış hâsılatına sahip, merkezi belli yerde
olan, birçok yerde faaliyette bulunan ve
kâr amaçlı şubelerdir. Bu kapsamda bu çalışmanın amacı, küreselleşme sürecinde
çok uluslu şirketlerin ekonomik açıdan bir değerlendirmesini yapmaktır. Bu
çalışmanın sonucunda, çok uluslu şirketlerin toplam gelirinin birçok ulus
devleti geride bırakarak ciddi boyutlara ulaştığı görülmektedir. Böylece çok
uluslu şirketlerin dünyadaki ticareti şekillendirerek dünya ekonomisine yön veren
en önemli aktörlerden biri olduğu sonucuna ulaşılmaktadır.
Students' Character Training through Game Online Extracurricular E-Sports in SMA 1 PSKD High School Jakarta
Authors: Waldi Atri , Irwan Irwan 
Published: December 2018

This study shows that the e-sports extracurricular program of SMA 1 PSKD Jakarta includes character value formation such as hard work, discipline, creativity, respect for achievement, communicative, peace-loving, and responsibility. This study used qualitative methods with a case study approach. The informants were chosen through in-depth interviews with students who chose e-sports development programs, e-sports coaches, the principal, and the teachers. The obstacle in implementing the e-sports program is the negative public stigma towards games and infrastructure that have not developed at the same level (school). To overcome these obstacles the school describe the e-sports to parents, where the e-sports program is a directed activity and includes guidance and supervision by e-sports coaches and coaches. Besides that, SMA 1 PSKD has an e-sports team that participates in existing e-sports events which are representatives of their schools in participating in the event.
Keywords: character training, E-Sports, SMA 1 PSKD Jakarta
Abstrak

Penelitian ini menunjukkan bahwa dalam program ekstrakurikuler e-sports di SMA 1 PSKD Jakarta terdapat esensi pembinaan nilai karakter berupa kerja keras, disiplin, kreatif, menghargai prestasi, komunikatif, cinta damai, dan tanggung jawab. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus. Informan dalam penelitian ini diambil melalui wawancara mendalam kepada pihak-pihak yang dinilai dapat memberikan data secara maksimal terkait pembentukan karakter melalui program pembinaan e-sports, seperti peserta didik yang memilih program pembinaan e-sports, pembina e-sports, kepala sekolah, serta guru. Kendala dalam pelaksanaan program e-sports adalah masih adanya stigma negatif masyarakat terhadap game dan Infrastuktur yang belum berkembang di level yang sama (sekolah). Untuk mengatasi kendala tersebut pihak sekolah mengkomunikasikan e-sports kepada orang tua peserta didik, bahwa program e-sports ini merupakan kegiatan yang terarah dan di dalamnya terdapat pembinaan dan pengawasan oleh pembina dan coach e-sports. Selain itu SMA 1 PSKD mempunyai tim e-sports yang mengikuti event-event e-sports yang ada yang merupakan perwakilan sekolahnya dalam mengikuti ajang tersebut.
Kata kunci: pembinaan karakter, E-Sports, SMA 1 PSKD Jakarta
Dasar-Dasar Teknik Bernyanyi Opera
Authors: Sinaga Theodora 
Published: December 2018

This study aims to analyze, Technique of Singing in Opera. The purpose of this research is to know Technique of Singing. The theory used is vocal technique, sound processing, sound formation, breathing, frasering, head voice, powering, vibrato, interpretation, singing, opera, aria, The method used in this research is qualitative descriptive method, namely a research method that aims to describe in detail and clearly about a phenomenon that became the focus of research. On the basis of it can be started that the overall appearance of Diana Damrau is interconnected to build on the builder’s point to make the appearance of Diana Damrau towards spectaculer.
Amenazas externas y Política de Defensa de Japón. Las modificaciones del gobierno de Abe
Authors: Zalazar Marina 
Published: December 2018

La política de defensa nipona es un caso particular de estudio por las limitaciones impuestas al país asiático luego de la Segunda Guerra Mundial. Estas condiciones presentes en el artículo 9 de la constitución continúan vigentes al día de hoy, aunque se las ha reinterpretado a lo largo de los años para que Japón amplíe cada vez más sus capacidades defensivas.
El primer ministro actual, Shinzo Abe, es quien ha introducido las modificaciones más importantes, que serán analizadas teniendo en cuenta nociones del realismo neoclásico para sostener la hipótesis de que las mismas han sido adoptadas en función de amenazas provenientes de China y Corea del Norte y de las presiones de Estados Unidos sobre el gobierno japonés.
Conceptualizando las relaciones argentino-estadounidenses recientes en materia de seguridad y defensa ¿Una relación de afinidades electivas?
Authors: Barreto Luis Maximiliano 
Published: December 2018

El objetivo de este artículo es estudiar la actualidad de una hipótesis que es recurrente en un sector de los estudios sobre la seguridad y la defensa en América Latina, circunscribiendo el abordaje al caso argentino bajo la administración de Mauricio Macri (desde su asunción hasta marzo de 2018). Si bien la hipótesis es esbozada con diferentes matices por los autores, genéricamente, se sostiene que Estados Unidos suele ser un actor afín al involucramiento de las respectivas Fuerzas Armadas latinoamericanas en hipótesis de conflicto internas. Esta afirmación contrasta con la postura de Washington en relación con sus militares, a los cuales no se los habilita para atender cuestiones de orden interno, fundamentalmente, desde la Posse Comitatus Act de 1878. A lo largo de las líneas, testear la mencionada hipótesis en relación con Argentina, implica abordar la distinción “seguridad interna” y “defensa nacional”, la cual tiene especial importancia desde fines de los años ’80 cuando comenzó el proceso de construcción de ambas como campos diferenciados.