bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Comparison of Axial Length Measurement With Three Swept-Source OCT-Based Biometers and Partial Coherence Interferometry
Authors: Huang Jinhai , Chen Hao , Li Yue , Chen Zhongxing , Gao Rongrong , Yu Jinjin , Zhao Yune , Lu Weicong , McAlinden Colm , Wang Qinmei 
Published: February 2019

PURPOSE:
To compare axial length measurements (and failure rate) of three swept-source optical coherence tomography (SS-OCT)–based biometers: IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany), OA-2000 (Tomey, Nagoya, Japan), and Argos (Movu Inc., Komaki, Japan) to those provided by a partial coherence interferometry (PCI)–based optical biometer (IOLMaster v5.4 [Carl Zeiss Meditec]).

METHODS:

A total of 119 patients (171 eyes) undergoing cataract surgery were enrolled. Axial length was measured with the four biometers in a random order. Chi-square analysis was used to determine whether statistically significant differences in success rates were found between biometers. Within-subject standard deviation (S
w
), test–retest repeatability (TRT), coefficient of variation (CoV), and intraclass correlation coefficients (ICCs) were calculated to analyze the intraobserver repeatability. Bland–Altman plots were used for agreement assessment.

RESULTS:

Axial length measurements were successfully measured in 166 eyes (97.08%) with the IOLMaster 700, 166 eyes (97.08%) with the OA-2000, 170 eyes (99.42%) with the Argos, and 138 eyes (80.70%) with the IOLMaster v5.4. Chi-square analysis indicated a significant difference in the failure rate between PCI- and SS-OCT–based biometers (
P
< .001). Intraobserver repeatability for the IOLMaster 700, OA-2000, and Argos showed excellent repeatability with low TRT (0.03, 0.06, and 0.05 mm, respectively), low CoV (0.04%, 0.10%, 0.07%, respectively), and high ICC (1.000, 0.999, and 1.000, respectively). The Bland–Altman 95% limits of agreement were as narrow as 0.09 mm, indicating excellent agreement among the three SS-OCT biometers and the PCI biometer.

CONCLUSIONS:
The three SS-OCT biometers showed a significantly higher success rate for axial length measurement than the IOLMaster v5.4 in various lens opacities. These SS-OCT biometers are likely to become the gold standard for axial measurement.

[
J Refract Surg.
2019;35(2):115–120.]
Haze and Visual Acuity Loss After Sequential Photorefractive Keratectomy and Corneal Cross-linking for Keratoconus
Authors: Moraes Renata L. B. , Ghanem Ramon C. , Ghanem Vinicius C. , Santhiago Marcony R. 
Published: February 2019

PURPOSE:
To investigate the results after photorefractive keratectomy (PRK) followed immediately by standard 30-minute corneal cross-linking (CXL) for keratoconus.

METHODS:
This retrospective study included 26 eyes of 16 patients with keratoconus. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction spherical equivalent (SE) and cylinder, apical keratometry, corneal higher order aberrations (HOAs), and corneal haze were evaluated.

RESULTS:

Mean follow-up was 32 ± 8 months (range: 19 to 50 months) and mean patient age was 31 ± 5 years (range: 24 to 40 years). Mean UDVA improved significantly from 0.80 ± 0.39 to 0.32 ± 0.36 logMAR after surgery (
P
< .001), but the mean CDVA worsened significantly from 0.07 ± 0.09 to 0.15 ± 0.14 logMAR after surgery (
P
= .006). Thirteen eyes (50%) lost at least one line of CDVA, 3 eyes (12%) lost two lines, and 4 eyes (15%) lost three lines. SE, cylinder, and apical keratometry decreased significantly. Corneal haze grade 1 was found in 15 eyes (57.7%), grade 2 in 6 eyes (23.1%), and grade 3 in 1 eye (3.8%). A significant correlation was seen between postoperative CDVA loss and corneal haze (
P
= .001) and history of atopy (
P
< .01), but not with corneal HOA change.

CONCLUSIONS:
Despite an improvement in UDVA and topographic values, the loss of CDVA, explained by postoperative haze, demonstrates that this procedure should be approached with caution, may not be as safe as initially thought, especially in patients with atopy and can cause severe visual acuity loss.

[
J Refract Surg
. 2019;35(2):109–114.]
The influence of transformed Reynolds number suppression on gas transfer parameterizations and global DMS and CO2 fluxes
Authors: Zavarsky Alexander , Marandino Christa A. 
Published: February 2019

Abstract. Eddy covariance measurements show gas transfer velocity suppression at medium to high wind speed. A
wind–wave interaction described by the transformed Reynolds number is used to
characterize environmental conditions favoring this suppression. We take the transformed
Reynolds number parameterization to review the two most cited wind speed gas transfer
velocity parameterizations: Nightingale et al. (2000) and Wanninkhof (1992, 2014). We propose an algorithm
to adjust k values for the effect of gas transfer suppression and validate it with two
directly measured dimethyl sulfide (DMS) gas transfer velocity data sets that experienced
gas transfer suppression. We also show that the data set used in the Nightingale 2000
parameterization experienced gas transfer suppression. A compensation of the suppression
effect leads to an average increase of 22 % in the k vs. u relationship. Performing
the same correction for Wanninkhof 2014 leads to an increase of 9.85 %. Additionally,
we applied our gas transfer suppression algorithm to global air–sea flux climatologies
of CO2 and DMS. The global application of gas transfer suppression leads to a
decrease of 11 % in DMS outgassing. We expect the magnitude of Reynolds suppression on
any global air–sea gas exchange to be about 10 %.
Modelos de negócios educacionais: uma revisão sistemática de literatura
Authors: Duarte Gwendole Ramos , Behr Ariel 
Published: February 2019

O avanço de tecnologias viabiliza novas possibilidades de modelos de negócios, gerando impacto também no contexto educacional. Por meio de uma abordagem descritiva e qualitativa, este estudo traz uma análise de conteúdo da literatura existente sobre Modelos de Negócios Educacionais, com o objetivo de apresentar uma revisão sistemática de literatura sobre Modelos de Negócios Educacionais. Os resultados apontaram o ano de 2004 como o início da discussão acadêmica sobre o assunto, além disso foram encontrados 16 conceitos de modelos de negócios educacionais presentes na literatura e duas estruturas com elementos genéricos aplicáveis à educação – uma para universidades do futuro e outra para e-Education. Instituições de ensino superior demonstraram ser os principais alvos relacionados a temática. As delimitações da pesquisa foram os resultados encontrados nas bases de dados por meio dos termos de busca e o fato da utilização apenas dos artigos de periódicos para análises mais aprofundadas e, portanto, faz-se necessário o estudo e aprofundamento de outros termos conceituados nesta pesquisa, bem como a discussão da agenda de debate proposta.
FORESEE: a tool for the systematic comparison of translational drug response modeling pipelines
Authors: Turnhoff Lisa-Katrin , Hadizadeh Esfahani Ali , Montazeri Maryam , Kusch Nina , Schuppert Andreas 
Published: February 2019

Translational models that utilize omics data generated in in vitro studies to predict the drug efficacy of anti-cancer compounds in patients are highly distinct, which complicates the benchmarking process for new computational approaches. In reaction to this, we introduce the uniFied translatiOnal dRug rESponsE prEdiction platform FORESEE, an open-source R-package. FORESEE not only provides a uniform data format for public cell line and patient data sets, but also establishes a standardized environment for drug response prediction pipelines, incorporating various state-of-the-art preprocessing methods, model training algorithms and validation techniques. The modular implementation of individual elements of the pipeline facilitates a straightforward development of combinatorial models, which can be used to re-evaluate and improve already existing pipelines as well as to develop new ones.
Availability and Implementation: FORESEE is licensed under GNU General Public License v3.0 and available at https://github.com/JRC-COMBINE/FORESEE .
Supplementary Information: Supplementary Files 1 and 2 provide detailed descriptions of the pipeline and the data preparation process, while Supplementary File 3 presents basic use cases of the package.
Contact: schuppert@combine.rwth-aachen.de
A use case centric survey of Blockchain: status quo and future directions
Authors: Perera Srinath , Leymann Frank , Fremantle Paul 
Published: February 2019

This paper presents an assessment of blockchain technology based on the Emerging Technology Analysis Canvas (ETAC) to evaluate the drivers and potential outcomes. The ETAC is a framework to critically analyze emerging technologies.
The assessment finds that blockchain can fundamentally transform the world. It is ready for specific applications in use cases such as digital currency, lightweight financial systems, ledgers, provenance, and disintermediation.
However, Blockchain faces significant technical gaps in other use cases and needs at least 5-10 years to come to full fruition in those spaces. Sustaining the current level of effort (e.g. startups, research) for this period of time may be challenging. We also find that the need and merits of decentralized infrastructures compared to centralized and semi-centralized alternatives is not always clear. Given the risk involved and significant potential returns, we recommend a cautiously optimistic approach to blockchain with the focus on concrete use cases.
The primary contributions of this paper are a use case centric categorization of the blockchain, a detailed discussion on challenges faced by those categories, and an assessment of their future.
Simulation Improves Podiatry Student Skills and Confidence in Conservative Sharp Debridement on Feet
Authors: Grollo Aspasia , Morphet Ashley , Shields Nora 
Published: February 2019

Background:
An essential skill for podiatrists is conservative sharp debridement of foot callus. Poor technique can result in lacerations, infections and possible amputation. This pilot trial explored whether adding simulation training to a traditional podiatry clinical placement improved podiatry student skills and confidence in conservative sharp debridement, compared with traditional clinical placement alone.

Methods:
Twenty-nine podiatry students were allocated randomly to either a control group or an intervention group on day 1 of their clinical placement. On day 4, the intervention group (n = 15) received a 2-hour simulation workshop using a medical foot-care model, and the control group (n = 14) received a 2-hour workshop on compression therapy. Both groups continued to learn debridement skills as opportunities arose while on clinical placement. The participants' debridement skills were rated by an assessor blinded to group allocation on day 1 and day 8 of their clinical placement. Participants also rated their confidence in conservative sharp debridement using a questionnaire. Data were analyzed using logistic regression (skills) and analysis of covariance (confidence), with baseline scores as a covariate.

Results:
At day 8, analysis showed that those in the intervention group were 16 times more likely to be assessed as competent (95% confidence interval, 1.6–167.4) in their debridement skills and reported increased confidence in their skills (mean difference, 3.2 units; 95% confidence interval, 0.5–5.9) compared with those in the control group.

Conclusions:
This preliminary evidence suggests that incorporating simulation into traditional podiatry clinical placements may improve student skills and confidence with conservative sharp debridement.
Assessment of Pulmonary Function After Osteopathic Manipulative Treatment vs Standard Pulmonary Rehabilitation in a Healthy Population
Authors: Lorenzo Santiago , Nicotra Cassandra M. , Mentreddy Akshay R. , Padia Hiral J. , Stewart Derek O. , Hussein Mohamed O. , Quinn Thomas A. 
Published: February 2019

Abstract

Context
Standard pulmonary rehabilitation (SPR) does not use osteopathic manipulative treatment (OMT), but OMT has potential to improve lung function and patient perception of breathing.

Objective
To analyze the immediate effects of OMT and SPR techniques on pulmonary function using spirometry and subjective ratings in young, healthy persons.

Methods
Participants were healthy students recruited from the Lake Erie College of Osteopathic Medicine-Bradenton and were randomly assigned to either the OMT or SPR group. During the first 4 weeks, each participant in the OMT group received 1 OMT technique (rib raising, doming of the diaphragm, thoracic lymphatic pump, and thoracic high velocity, low amplitude), and each participant in the SPR group received 1 SPR treatment (tapotement, pursed lip breathing, saline nebulizer, and rest) per week. Treatments were then ranked based on positive change in pulmonary function as measured by forced expiratory volume in the first second of expiration (FEV1) and forced vital capacity (FVC). During the fifth week, the OMT group received the 2 highest-ranked OMT techniques, and the SPR group received the 2 highest-ranked SPR treatments. During the sixth week, the OMT group received the highest-ranked OMT and SPR treatment, while the SPR group received the same treatment combination but in the reverse order. Pulmonary function, as measured through FEV1, FVC, and FEV1/FVC, were collected before and after each treatment or treatment combination. Participants subjectively rated change in breathing after each treatment.

Results
A total of 53 students participated in the study, with 28 in the OMT group and 25 in the SPR group. In the OMT group, rib raising yielded the highest positive mean (SD) change of 0.001 (0.136) L in FEV1 and 0.052 (0.183) L in FVC, followed by lymphatic pump, with a change of 0.080 (0.169) L in FEV1 and −0.031 (0.229) L in FVC. In the SPR group, pursed lip breathing yielded the highest positive mean (SD) change of 0.101 (0.278) L in FEV1 and 0.031 (0.179) L in FVC, followed by tapotement, with a change of 0.045 (0.229) L in FEV1 and 0.061 (0.239) L in FVC. Saline treatment significantly decreased lung function. All other treatments did not result in any significant changes in lung function. Overall, SPR subjective ratings were significantly lower than ratings for both OMT and combination (OMT+SPR) treatments.

Conclusions
Saline significantly reduced lung function and had low subjective posttreatment ratings in young healthy adults. Additionally, OMT and combination OMT and SPR significantly improved subjective breathing more than SPR alone. Future applications of this study include evaluating OMT and SPR effects on lung function in patients with various pulmonary conditions.
Discordant financial conflicts of interest disclosures between clinical trial conference abstract and subsequent publication
Authors: Weiss Glen J. , Davis Roger B. 
Published: February 2019

Background
Financial conflicts of interest (FCOI) are known to be prevalent in medicine. Authorship of pivotal trials reap non-financial benefits including publication productivity that can be used for assessment of tenure positions and promotion. The purpose of this investigation was to quantify the prevalence and discordance of academic trial author (authors) FCOI in industry-sponsored drug trials that were initially presented as oral abstracts and subsequently resulted in a peer-reviewed publication.

Methods
Oral abstracts from the American Society of Clinical Oncology (ASCO) 2017 Annual Meeting that were subsequently published were identified. Studies that were non-industry sponsored, non-adult, or non-therapeutic trials were excluded. Studies that did not have a subsequent peer-reviewed publication or had a publication preceding the ASCO 2017 Annual Meeting were also excluded. FCOI was categorized and impact factor (IF) for the journal at the time of publication was retrieved. FCOI discordance between the oral abstract and publication was calculated based on geographic location and IF.

Results
A total of 22 paired abstract and publications met inclusion criteria for further analysis. A total of 384 authors were identified, of these 280 authors (74.1%) were included in both the oral abstract and subsequent publication. A total of 76% of these 280 authors had FCOI and 66.4% had FCOI discordance. There were statistically significant differences for the sum of FCOI discordance for U.S.-based authors (p = 0.0004) but not for journal IF. When analyzing the sum of absolute differences of FCOI discordance, statistical significance was reached for authors from any of the three geographic regions, as well as, low and high IF journals (all p-values < 0.0001).

Conclusions
This study draws attention to the lack of uniformity and vetting of FCOI reporting in abstracts and journals publishing solid tumor oncology trial results. This is particularly concerning, since FCOI is prevalent globally.
Artificial Intelligence and Radiologist Burnout
Authors: Liu Hui , Ding Ning , Li Xinying , Chen Yunli , Sun Hao , Huang Yuanyuan , Liu Chen , Ye Pengpeng , Jin Zhengyu , Bao Heling , Xue Huadan 
Published: November 2024

IMPORTANCEUnderstanding the association of artificial intelligence (AI) with physician burnout is crucial for fostering a collaborative interactive environment between physicians and AI.OBJECTIVETo estimate the association between AI use in radiology and radiologist burnout.DESIGN, SETTING, AND PARTICIPANTSThis cross-sectional study conducted a questionnaire survey between May and October 2023, using the national quality control system of radiology in China. Participants included radiologists from 1143 hospitals. Radiologists reporting regular or consistent AI use were categorized as the AI group. Statistical analysis was performed from October 2023 to May 2024.EXPOSUREAI use in radiology practice.MAIN OUTCOMES AND MEASURESBurnout was defined by emotional exhaustion (EE) or depersonalization according to the Maslach Burnout Inventory. Workload was assessed based on working hours, number of image interpretations, hospital level, device type, and role in the workflow. AI acceptance was determined via latent class analysis considering AI-related knowledge, attitude, confidence, and intention. Propensity score–based mixed-effect generalized linear logistic regression was used to estimate the associations between AI use and burnout and its components. Interactions of AI use, workload, and AI acceptance were assessed on additive and multiplicative scales.RESULTSAmong 6726 radiologists included in this study, 2376 (35.3%) were female and 4350 (64.7%) were male; the median (IQR) age was 41 (34-48) years; 3017 were in the AI group (1134 [37.6%] female; median [IQR] age, 40 [33-47] years) and 3709 in the non-AI group (1242 [33.5%] female; median [IQR] age, 42 [34-49] years). The weighted prevalence of burnout was significantly higher in the AI group compared with the non-AI group (40.9% vs 38.6%; P &amp;lt; .001). After adjusting for covariates, AI use was significantly associated with increased odds of burnout (odds ratio [OR], 1.20; 95% CI, 1.10-1.30), primarily driven by its association with EE (OR, 1.21; 95% CI, 1.10-1.34). A dose-response association was observed between the frequency of AI use and burnout (P for trend &amp;lt; .001). The associations were more pronounced among radiologists with high workload and lower AI acceptance. A significant negative interaction was noted between high AI acceptance and AI use.CONCLUSIONS AND RELEVANCEIn this cross-sectional study of radiologist burnout, frequent AI use was associated with an increased risk of radiologist burnout, particularly among those with high workload or lower AI acceptance. Further longitudinal studies are needed to provide more evidence.
Hybridization of Terahertz Phonons and Magnons in Disparate and Spatially‐Separated Material Specimens
Authors: Białek M. , Todorov Y. , Stelmaszczyk K. , Szwagierczak D. , Synkiewicz‐Musialska B. , Kulawik J. , Pałka N. , Potemski M. , Knap W. 
Published: November 2024

AbstractThe interaction between condensed matter excitations and electromagnetic cavity fields serves as a rich playground for fundamental research and lies at the core of photonic and quantum technologies. Herein, the intriguing concept of composite states formed by distinct quasiparticles strongly coupled to the same optical cavity modes is experimentally and theoretically demonstrated. Specifically, magnons excited in a slab of an antiferromagnetic crystal and phonons excited in a distinct specimen of an insulating material are explored. The crystal slabs form an optical cavity with Fabry–Pérot oscillations in the terahertz range. Hybridized phonon–magnon polariton modes and their tunability by adjusting the distance between the slabs, showing that hybridization persists even at separations of up to several millimeters is demonstrated. The experimental results are interpreted using both classical and quantum electrodynamical models. The quantum description allows us to quantify the degree of hybridization linked to a topological behavior of the electric field phasor, in agreement with the classical electrodynamics expectations. The presented results are obtained at room temperature and cavities of millimeter size, paving the way for the engineering of realistic, frequency‐tunable THz devices through the hybridization of electric (phononics) and magnetic (spintronics) elementary excitations of matter.
A Nepenthes‐Inspired Hydrogel Hybrid System for Sweat‐Wicking Electrophysiological Signal Recording during Exercises
Authors: Yang Ganguang , Lan Zhaogang , Gong Hangyu , Wen Jiacheng , Pang Bo , Qiu Yuqi , Zhang Yue , Guo Wei , Bu Tianzhao , Xie Bin , Wu Hao 
Published: November 2024

AbstractCollecting electrophysiological (EP) signals (e.g., electrocardiogram (ECG), electromyogram (EMG)) during exercises is crucial for feedback of cardiac health and muscle injuries. However, since several interferences exist in the skin interface (e.g., deformation, perspiration, and motion artifacts), commercial rigid electrodes/systems have difficulty in recording high‐fidelity EP signals. Here, a wireless Nepenthes‐inspired hydrogel (NIH) hybrid system is developed for high‐quality EP signal detection by establishing seamless‐integrated and rapidly directional sweat‐wicking device/skin interfaces during exercises. The adhesive strength of poly(vinyl alcohol)/poly(acrylic acid) (PVA/PAAC)‐based double‐network hydrogels is significantly increased by more than sixfolds. Nepenthes‐inspired microstructures are further fabricated on hydrogels to enhance the directional transport speed of droplets by 4.5 times. Notably, the NIH electrodes can maintain an intimate coupling with the skin during continuous artificial sweat injection while showing the lowest impedance and highest signal‐to‐noise ratio (>19 dB) of EMG signals under complex conditions (i.e., vibration and perspiration). Finally, the NIH hybrid system is fabricated by decorating silicone joints and hollow structures to avoid stress concentration. This system can record high‐quality ECG waveforms and heart rate curves with relative deviations of <2.6% during exercises and rest. This NIH hybrid system represents a promising platform for precise EP signal monitoring in exercising scenarios.