bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concentración/dispersión en Santa Fe, Argentina: problemáticas e interrogantes sobre los procesos urbanos contemporáneos en una ciudad media de América Latina
Authors: Rausch Gisela Ariana , Martínez Irene , Nardelli Mariana Lis , Szupiany Estefanía 
Published: April 2019

Se discuten problemáticas territoriales contemporáneas en Santa Fe, Argentina, relativas a procesos de concentración y dispersión urbana. Se sostiene que aquellas son la manifestación de estrategias neoliberales de mercantilización espacial, que responden en parte a lógicas globales y a características comunes de las ciudades de América Latina. Se busca dar cuenta del modo en que las lógicas neoliberales globales se cristalizan en contextos locales y, particularmente, en una ciudad de tamaño medio. Los resultados exponen especificidades de los procesos de producción espacial en la última fase del capitalismo, expresadas en el aumento de la marginalidad socioeconómica, la conformación de enclaves urbanos, las urbanizaciones difusas sobre ejes viales y los procesos de verticalización.Ideas destacadas: artículo de reflexión que aborda los modos específicos en que se manifiestan las políticas neoliberales globales en el caso de la ciudad de Santa Fe (Argentina), ciudad que no manifiesta una metropolización desarrollada, pero posee dinámicas de concentración y dispersión en el nivel regional.
Tres versiones de la orfandad en la poesía de César Vallejo
Authors: Rodríguez Zapata Irma Aniela 
Published: April 2019

En la vasta obra poética de César Vallejo, es posible identificar la ausencia y la nostalgia del tiempo pasado como registros temáticos presentes con cierta frecuencia. El presente artículo estudia el concepto de orfandad a través de tres variaciones del desamparo en la poesía de Vallejo. Para ello, se examinan aquí elementos tales como el espacio habitado, la figura de la madre y los paraísos perdidos, con la finalidad de indagar y contrastar las diferentes manifestaciones de la orfandad en el universo vallejiano.
Palabras clave: orfandad, ausencia, César Vallejo, poesía, paraísos perdidos, espacio habitado.
Attachment and problematic Facebook use in adolescents: The mediating role of metacognitions
Authors: Marino Claudia , Marci Tatiana , Ferrante Lucrezia , Altoè Gianmarco , Vieno Alessio , Simonelli Alessandra , Caselli Gabriele , Spada Marcantonio M. 
Published: April 2019

Background and aims
Recent research used attachment theory and the metacognitive tenet as frameworks to explain problematic Facebook use (PFU). This study aims to test, in a single model, the role of different attachment styles and metacognitions in PFU among adolescents.

Methods
Two separate studies were conducted in order to establish the link between security (Study 1) and insecurity (Study 2), metacognitions, and PFU. A total of 369 and 442 Italian adolescents (age: 14–20 years old) participated in Study 1 and Study 2, respectively.

Results
Path analyses revealed the relative importance of different attachment dimensions with mother and father in predicting PFU and the mediating role of metacognitions between attachment styles and PFU.

Discussion and conclusion
In conclusion, since attachment styles and PFU may significantly affect adolescents’ development and well-being, the results of this study may provide some practical indications for researchers and practitioners.
Severe Epididymo-Orchitis and Encephalitis Complicating Anti-PD-1 Therapy
Authors: Quach Henry T. , Robbins Charles J. , Balko Justin M. , Chiu Charles Y. , Miller Steve , Wilson Michael R. , Nelson George E. , Johnson Douglas B. 
Published: April 2019

Abstract

Background
Immune checkpoint inhibitors such as pembrolizumab and nivolumab have emerged as active treatment options for patients with many cancers, including metastatic melanoma, but can also cause symptomatic or life-threatening immune-related adverse events, including encephalitis. Epididymitis and orchitis are rare complications of these therapies.

Case Presentation
We describe herein a patient with metastatic melanoma who developed epididymo-orchitis followed by encephalitis while receiving pembrolizumab. The patient developed testicular pain and fever after his third dose of pembrolizumab; ultrasound evaluation demonstrated bilateral epididymo-orchitis. He then developed headaches, fever, and altered mental status over the next week and was admitted to the hospital. Lumbar puncture revealed inflammatory changes consistent with meningoencephalitis; he did not improve with broad-spectrum antibiotics, and an extensive workup for infectious etiologies, including cerebrospinal fluid testing using a clinical metagenomic next-generation sequencing assay, was negative. He received high-dose steroids for suspected autoimmune encephalitis, and both his orchitis and meningoencephalitis improved rapidly after one dose. He fully recovered after a 5-week taper of oral steroids.

Discussion
Here, we report a case of epididymo-orchitis complicating immune checkpoint inhibitor therapy. This patient subsequently developed severe encephalitis but rapidly improved with steroids. Clinicians should be aware of rare complications of these agents.

Key Points
Epididymo-orchitis is a rare and potentially life-threatening complication of anti-programmed death protein 1 (anti-PD-1) therapy. For patients on anti-PD-1 therapy who develop either epididymo-orchitis or epididymitis without clear infectious cause, immune-related adverse events should be considered in the differential diagnosis. If severe, epididymo-orchitis related to anti-PD-1 therapy may be treated with high-dose corticosteroids.
Reservoir Computing: uma Abordagem Conceitual
Authors: Oliveira Estevao Rada , Juliani Fernando 
Published: April 2019

Reservoir computing é um paradigma de rede neural recorrente construída de forma aleatória, onde sua camada intermediária não necessita ser treinada. O presente artigo sintetiza os principais conceitos, métodos e pesquisas recentes realizadas sobre o paradigma de reservoir computing, objetivando servir como apoio teórico para outros artigos. Foi realizada uma revisão bibliográfica fundamentada em bases de conhecimento científico confiáveis enfatizando pesquisas compreendidas no período de 2007 a 2017 e direcionadas à implementação e otimização do paradigma em questão. Como resultado do trabalho, tem-se a apresentação de trabalhos recentes que contribuem de forma geral para o desenvolvimento de reservoir computing, e devido à atualidade do tema, é apresentada uma diversidade de tópicos abertos à pesquisa, podendo servir como norteamento para a comunidade científica. Palavras-chave: Aprendizado de Máquina. Inteligência Artificial. Redes Neurais Recorrentes.Abstract Reservoir computng is a randomly constructed recurrent neural network paradigm, where the hidden layer does not need to be trained. This article summarizes the main concepts, methods and recent researches about reservoir computing paradigm, aiming to offer a theoretical support for other articles. Were made a bibliographic review based on reliable scientific knowledge bases, emphasizing researches published between 2007 and 2017 and focused on implementation and optimization of aforementioned paradigm. As a result, there's a report of recent articles that contribute in general to the development of reservoir computing, and due to its topicality, a diversity of topics that are still open to research are given, that may possibly work as a guide for the research community. Keywords: Artificial Intelligence. Machine Learning. Recurrent Neural Network.
Integração da Análise Conjunta e Fuzzy-AHP para Identificação e Mensuração de Atributos em Produtos
Authors: Ulhoa Túlio Fígaro , Camioto Flávia De Castro , Lima Rafael Henrique Palma , Osiro Lauro 
Published: April 2019

A identificação dos atributos mais relevantes para os consumidores está atrelada a definição de um conjunto de critérios que representam aspectos importantes para satisfazer as necessidades desses clientes. Dessa forma, mensurar a importância relativa dos atributos se mostra uma atividade essencial para atingir o mercado-alvo de produtos e satisfazer os consumidores. Para isso, técnicas podem ser utilizadas, como a Análise Conjunta e o Fuzzy-AHP, as quais possuem peculiaridades, benefícios e limitações que podem ser comparadas para encontrar respostas mais adequadas para o problema de identificação de necessidades. O foco do presente estudo é comparar as técnicas de Análise Conjunta e Fuzzy-AHP para analisar seus resultados quanto as suas características, vantagens e desvantagens. Esse estudo foi apoiado por uma aplicação de ambas as técnicas com consumidores de fones de ouvido, por meio de pesquisas de mercado. Destaca-se que os resultados da aplicação indicam que existe diferença significativa entre as técnicas, porém essas diferenças podem estar mais relacionadas a fatores como atributos específicos. Percebe-se, no geral, que a Análise Conjunta pode ser mais adequada para detalhar análises, enquanto que o Fuzzy-AHP pode ser utilizado para obter resultados mais rapidamente. Além disso, entende-se que ambas as técnicas poderiam ser utilizadas em conjunto para atingir objetivos de identificação de atributos de produtos, bem como outros usos desse estudo em futuros trabalhos. Palavras-chave: Análise Conjunta. Fuzzy-AHP. Melhoria de Produtos. Satisfação dos Clientes. AbstractThe identification of the most relevant attributes for consumers requires the definition of a set of criteria that represent important aspects to satisfy the needs of these clients. Therefore, measuring the relative importance of attributes is an essential activity to provide products that will satisfy consumers in a given market. To this aim, techniques as Fuzzy-AHP and conjoint analysis can be applied, each of which having benefits and limitations that can be compared to give a more complete analysis to a certain product. The objective of this paper is to compare how conjoint analysis and Fuzzy-AHP perform in measuring product attributes, which may assist the product development and improvement processes. This study was conducted by applying both techniques to headphone consumers, through market research. Results indicate significant difference between both approaches, which may be more related to factors such as the attributes included in the analysis. A major conclusion is that conjoint analysis is more suited for detailed analyses whereas Fuzzy-AHP provides results more quickly. In addition, both techniques can be used together to enable a more comprehensive analysis of product attributes. Keywords: Conjoint Analysis. Fuzzy AHP. Product Improvement. Customer Satisfaction.
Cedera olahraga serta penyakit terkait olahraga
Authors: Setyaningrum Dyah Ayu Woro 
Published: April 2019

Cedera olahraga didefinisikan sebagai cedera yang terjadi pada tubuh saat seseorang berolahraga atau saat melakukan latihan fisik tertentu. Cedera Olahraga tidak hanya berupa kerusakan yang mendadak yang terjadi saat olahraga misal seperti strains dan laserasi pada jaringan lunak sistem muskuloskeletal namun termasuk didalamnya adalah sindroma overuse yang merupakan akibat jangka panjang dari sesi latihan dengan gerakan atau postur tubuh yang monoton dan berulang-ulang sehingga muncul manifestasi klinis. Cedera olahraga didefinisikan sebagai cedera yang terjadi pada tubuh saat seseorang berolahraga atau saat melakukan latihan fisik tertentu. Cedera Olahraga tidak hanya berupa kerusakan yang mendadak yang terjadi saat olahraga misal seperti strains dan laserasi pada jaringan lunak sistem muskuloskeletal namun termasuk didalamnya adalah sindroma overuse yang merupakan akibat jangka panjang dari sesi latihan dengan gerakan atau postur tubuh yang monoton dan berulang-ulang sehingga muncul manifestasi klinis. Pada bidang kedokteran olahraga muncul terminologi seperti overreaching functional atau non-functional overreaching merupakan istilah yang berkaitan dengan kinerja atau performa olahragawan atau atlet. Kondisi ini mempengaruhi proses penyembuhan serta beban latihan pada atlet tersebut. Adapula sindroma overtraining secara klinis terbagi menjadi dua jenis yaitu bentuk simpatetik dan parasimpatetik. Rata-rata cedera olahraga lebih tinggi secara bermakna pada cedera yang terjadi saat pertandingan dibandingkan cedera saat latihan dan lebih dari 50% cedera yang dialami atlet mengenai ekstremitas bawah. Cedera ACL serta re-injury nyadi Amerika Serikat merupakan cedera lutut yang paling sering, dan diperkirakan di AS saja mencapai angka 350.000 operasi rekonstruksi per tahunnya, dan perkiraan kasar rata-rata operasi untuk ACL di seluruh dunia sekitar satu juta kali. Tingginya cedera berulang (re-injury) dipengaruhi oleh keputusan kapan seorang atlet boleh kembali pada aktivitas olahraga sebelum cedera. Aspek kesehatan dan kerentanan atlet terhadap penyakit-penyakit infeksi tertentu juga perlu diperhatikan karena adanya pengaruh latihan terhadap imunitas.
Protein pengikat hormon seks: sex hormone binding globulin (SHBG) dan aksi steroid seks
Authors: Guyansyah Assangga , Parwanto ML Edy 
Published: April 2019

Jumlah gen pada manusia sekitar 30 000 gen, salah satunya yaitu gen SHBG (sex hormone binding globulin). Telah terbukti bahwa protein merupakan produk gen. Gen yang diekspresikan berarti mengkode sintesis protein. Pada studi ini mempelajari tentang protein sex hormone binding globulin (SHBG) yang merupakan produk gen SHBG. Gen SHBG terletak pada kromosom 17 p 3.1 di setiap sel tubuh kita. Gen SHBG pada hepatosit mengkode protein SHBG, protein tersebut selanjutnya disekresikan ke sistem sirkulasi. Gen SHBG di dalam hepatosit memiliki kesamaan dengan gen androgen binding protein (ABP) di sel Sertoli dalam testis. Jumlah gen pada manusia sekitar 30 000 gen, salah satunya yaitu gen SHBG (sex hormone binding globulin). Telah terbukti bahwa protein merupakan produk gen. Gen yang diekspresikan berarti mengkode sintesis protein. Pada studi ini mempelajari tentang protein sex hormone binding globulin (SHBG) yang merupakan produk gen SHBG. Gen SHBG terletak pada kromosom 17 p 3.1 di setiap sel tubuh kita. Gen SHBG pada hepatosit mengkode protein SHBG, protein tersebut selanjutnya disekresikan ke sistem sirkulasi. Gen SHBG di dalam hepatosit memiliki kesamaan dengan gen androgen binding protein (ABP) di sel Sertoli dalam testis. Dalam sisntesis protein SHBG maupun ABP ada 2 tahap yaitu tahap sintesis prekursor protein dan tahap selanjutnya pematangan prekursor protein di badan Golgi dengan proses glikosilasi. Protein SHBG maupun ABP memiliki funsgi sama yaitu memperantarai aksi hormon steroid seks ke sel sasaran. Ikatan antara SHBG dengan steroid tersebut bersifat reversibel dan berafinitas tinggi untuk mengikat androgen (dehidrotestosteron/DHT, testosteron, 3α-androstenediol), sedangkan ikatan terhadap estrogen aktif maupun estradiol dengan afinitas yang lebih rendah. Aksi steroid seks ke sel sasaran telah terbukti dengan 2 cara yaitu cara pertama dengan berdifusi melewati membran sel sasaran dan cara kedua dengan sistem transduksi sinyal yang diperantarai oleh reseptor SHBG (R-SHBG) pada permukaan sel sasaran. Protein SHBG di dalam sistem sirkulasi memiliki fungsi untuk mengikat hormon steroid seks dan memperantarai aksi hormon tersebut ke sel sasaran di luar testis, sedangkan ABP berfungsi memperantarai aksi hormon steroid seks di dalam testis.
A saúde bucal no povo indígena Wajãpi do estado do Amapá
Authors: Souza Tiago Araújo Coelho de , Ferreira Efigênia Ferreira e 
Published: April 2019

Este artigo tem como objetivo descrever
alguns aspectos das representações sócioculturais
da população indígena Wajãpi/AP,
identificar os hábitos e as transformações
nos padrões alimentares deste povo e fazer
um paralelo deste contexto com o perfil
epidemiológico em saúde bucal. O estudo
foi desenvolvido através de uma pesquisa
quali-quantitativa, onde através dos registros
discursivos, observacionais e epidemiológicos
buscou-se conhecer a concepção e a condição de
saúde bucal entre os Wajãpi/AP. Os resultados
demonstraram que a intensificação do processo
de contato com a sociedade nacional introduziu
a prática do assalariamento, proporcionou
mudanças de hábitos e influenciou o aumento
do consumo de alimentos industrializados. A
polarização dos componentes que constituem o
índice CPO-D e a condição dentária encontrada
evidenciam diferenças no acesso ao tratamento
em saúde bucal segundo a localização
geográfica das aldeias.
An Exploratory Survey of the Employment Concerns and Experiences of People With Parkinson's Disease: Implications for Rehabilitation Research, Policy, and Education
Authors: McDaniels Bradley 
Published: April 2019

PurposeLittle is known about the employment-related decisions made by people with Parkinson's disease (PD). This study investigated the extent to which individuals diagnosed with PD would prefer to continue working or, if currently unemployed, reenter the workforce.MethodThis quantitative survey research design consisted of a purposive sample of people with PD. A total of 80 surveys were completed and returned and, after eliminating those not meeting the inclusion criteria, 58 usable surveys were included in the final analysis.ResultsOver 82% of participants reported leaving work as a direct result of symptoms associated with PD, with the most common being inability to keep up with the physical demands (17.9%), fatigue (12.5%), psychological or cognitive issues (10.7%), and tremors (7.1%). The majority of respondents (64.3%) responded that they were moderately-to-very interested in returning to work if given the right conditions and supports.ConclusionsThe results indicated that individuals with PD would, in the right situation, prefer to reenter the workforce. Rehabilitation counselors need to be adequately equipped with information and resources to assist those with PD in determining potential employment options and ensuring that acceptable accommodations are provided. Implications for rehabilitation counseling practice, research, policy, and education are presented.
O Indicador de Desenvolvimento Regional no Território do Tocantins
Authors: Oliveira Nilton Marques , Piffer Moacir , Strassburg Udo 
Published: April 2019

O presente artigo tem por objetivo analisar o desenvolvimento regional do Estado do Tocantins, a partir da elaboração do Indicador de Desenvolvimento Regional (IDR) entre 2000 e 2010, com dados secundários coletados. Os principais resultados sugerem que no IDR do território do Estado do Tocantins, que possuía 139 municípios em 2000, apenas 15 foram classificados como polos de desenvolvimento, 34 em estágio intermediário e 90 em estágio retardatário. Conclui-se que houve melhoria no IDR em todo território do Tocantins, no entanto, nos municípios localizados ao longo da BR-153 (Belém-Brasília), as atividades econômicas mostraram-se mais dinâmicas.
Produktivitas dan Eﬁsiensi Teknis Usaha Perkebunan Kopi di Sumatera Selatan dan Lampung
Authors: Zen Fauziah , Budiasih Budiasih 
Published: April 2019

Coffee is the result of Indonesian plantations that have high competitiveness in the international market. However, coffee plantations in Indonesia have low productivity compared to other major coffee producing countries. This study aims to conduct a study of the productivity and technical efficiency of households coffee plantation business in the coffee producing center in Indonesia. The results of this study indicate that more than 50% of coffee plantation businesses in each of provinces have low productivity and medium technical efficiency. Education level is a variable that can increase productivity and technical efficiency signiﬁcantly. ============================ Kopi adalah hasil perkebunan Indonesia yang mempunyai daya saing tinggi di pasar internasional. Namun, perkebunan kopi di Indonesia memiliki produktivitas yang rendah dibandingkan negara-negara produsen utama kopi lainnya. Penelitian ini bertujuan untuk melakukan kajian terhadap produktivitas dan eﬁsiensi teknis usaha rumah tangga perkebunan kopi di provinsi sentra penghasil kopi di Indonesia. Hasil penelitian ini menunjukkan bahwa lebih dari 50% usaha perkebunan kopi di masing-masing provinsi tersebut memiliki produktivitas rendah dan eﬁsiensi teknis menengah. Tingkat pendidikan merupakan variabel yang dapat meningkatkan produktivitas dan eﬁsiensi teknis secara signiﬁkan.
A discrete time domain approach on time delay estimation
Authors: Kekalainen Jorma 
Published: April 2019

A time delay estimation method based on the discrete time domain approach is introduced here. In this dual-channel time delay estimation model, the criterion function compares the time differences of time sequences between channels, not the magnitude values of time functions as in the conventional cross-correlation method. An estimation task is formulated as an extreme value problem in discrete index space. Using the index delay giving extreme value to the criterion function, it is possible to find the best estimate for time delay distribution in the meaning of that criterion. Using this method, the estimated delay distribution and criterion function are clearly separated. Thus, there are no theoretical problems in the determination of the average time delay or velocity in the non-constant or changing time delay case as long as a sufficient statistical similarity (correlation) exists between channel signals. <p class="Abstract">The theoretical values of several criterion functions and the probability of occurrence of an anomalous estimate with the cross-covariance criterion function are derived. A basic performance analysis of the estimation method is presented. Some potential real-time supervision methods based on the use of criterion functions in the detection of the possible unreliability of the time delay estimate are outlined.</p>
ANALISIS KEMAMPUAN PEMECAHAN MASALAHMATEMATIKA BERDASARKAN LANGKAH POLYA PADA MATERI SISTEMPERSAMAAN LINEAR DUA VARIABEL KELAS VIII SMP PGRI 4 KALIPARE MALANG
Authors: Yulianto Gogot Dwi , Suastika I Ketut , Fayeldi Trija 
Published: April 2019

Fokus penelitian ini adalah untuk menganalisis kemampuan pemecahan masalah berdasarkan langkah Polya dan penyebab kesalahan siswa dalam melakukan pemecahan masalah matematika. Penelitian ini merupakan penelitian kualitatif dan jenis penelitiannya adalah studi kasus. Subyek penelitian adalah siswa kelas VIII SMP PGRI 4 Kalipare Malang. Prosedur pengumpulan data menggunakan tes untuk mengetahui kemampuan pemecahan masalah, wawancara untuk mengetahui penyebab kesalahan siswa, dan validasi untuk memvalidasi tes. Hasil dari penelitian ini yaitu (1) hasil validasi soal dari validator yaitu soal valid dan dapat digunakan dengan sedikit revisi, (2) hasil tes menunjukkan tingkat 1 terdapat 13 siswa, tingkat 2 terdapat 3 siswa, tingkat 3 terdapat 5 siswa dan tingkat 4 terdapat 1 siswa. Kesimpulan penelitian ini yaitu siswa dibagi menjadi 4 tingkatan kemampuan pemecahan masalah menurut langkah Polya yaitu tingkat 1 tidak mampu menyelesaikan langkah pemecahan masalah Polya sama sekali, tingkat 2 siswa hanya mampu memahami masalah, tingkat 3 siswa mampu memahami masalah, menyusun rencana penyelesaian dan melaksanakan rencana penyelesaian, dan tingkat 4 siswa mampu melaksanakan 4 langkah pemecahan masalah Polya.Beberapa penyebab kesalahan siswa yaitu siswa tidak memahami materi dan teknik menyelesaikan soal, kurang konsentrasi, tidak membuat kesimpulan akhir, dan kurang teliti.
DÍAZ ALARCÓN, Soledad (ed.). Introducción a la práctica de la traducción especializada (EN/FR>ES). Colección Nuevos Horizontes. Córdoba: UCOPress, 2018, 259 páginas. ISBN: 978-84-9927-340-2
Authors: Moreno Paz María del Carmen 
Published: April 2019

Reseña de: Díaz Alarcón, Soledad (ed.). Introducción a la práctica de la traducción especializada (EN/FR>ES). Colección Nuevos Horizontes. Córdoba: UCOPress, 2018, 259 páginas. ISBN: 978-84-9927-340-2.