bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnostic performance of optical coherence tomography and optical coherence tomography angiography for early primary open-angle glaucoma: a cross-sectional study
Authors: Li Yanjie , Liu Weishai , Bai Zichao , Cao Rongxia , Ren Haihua 
Published: October 2019

Abstract
Background: Primary open angle glaucoma (POAG) is often delayed in diagnosis and treatment, as it has no acute attack period, and symptoms usually appear at a relatively late stage. Optical coherence tomography angiography (OCTA) on the basis of Carl Zeiss optical coherence tomography with the support of FOURM platform is recently available in China. It is reportedly more sensitive to POAG. We reported the diagnostic utilities of OCTA and OCT which is already in clinical practice. Methods: 15 patients (23 eyes) with early POAG as observation group and 30 health people (30 eyes) as normal control group were enrolled in this cross-sectional study. OCTA-based superficial macula vessel density, superficial macula perfusion density, superficial optic disc vessel density, superficial optic disc perfusion density and OCT-based macula thickness, ganglion cell complex (GCC) thickness and retinal nerve fiber layer (RNFL) thickness were recorded in ​​the two groups. Independent sample t-test and receiver operating characteristic curve were used for statistical analysis. Area under the receiver operating characteristic curves (AUCs) were used to measure the diagnostic utility.Results: The optimal diagnostic utility parameters were the superficial vessel density and perfusion density in the macula (except the center of macula), and the AUCs were above 0.97. Followed by the superficial vessel density and perfusion density in the optic disc area. The OCT-based diagnostic utility parameters were generally lower than that mentioned above, the top three parameters were the inferior RNFL thickness (AUC=0.919), the superior GCC thickness (AUC=0.919) and the inferior GCC thickness (AUC = 0.908).Conclusions: Changes of thickness in macula, GCC, RNFL, and changes of superficial vessel density and perfusion density in the optic disc or in macula can be detected by OCT or by OCTA in early POAG. The OCTA-based diagnostic utility was generally higher than the OCT-based diagnostic utility.
The reverse sleeve in total hip arthroplasty for patients with trochanter valgus deformity: surgical technique and case series
Authors: Kong Xiangpeng , Chai Wei , Yang Minzhi , Ong Alvin , Chen Jiying , Wang Yan , Zhou Yonggang 
Published: October 2019

Abstract
Background: Ttrochanter valgus deformity (TVD) is a rare condition of total hip arthroplasty (THA). The femoral osteotomy might be required to correct the deformity to implant the femoral stem in severe TVD. In this study, we described one unpublished technique of reverse sleeve of S-ROM to get through the complex situation. The aim of this study was to summarize the technical challenges of this special sleeve-implanting method and evaluate its effectiveness and safety. Methods: From January 2006 to December 2014, the patients who had the reverse sleeve to solve the TVD in THA were enrolled. Their demographics, perioperative and postoperative information were recorded. To explore its indication, we measured and analyzed the ratio of greater trochanter/lesser trochanter (G/L ratio) and trochanter valgus angle (TVA). Results: Twelve patients (1 male and 11 female, average age 42.30±10.23) who had the complete clinical data were analyzed. The survivorship of femoral prosthesis were 100% with mean follow-up of 6 years. No other complications were found, except for two patients with intraoperative fracture of femur. The Harris hip score (HHS) increased from preoperative 34.31±14.43 to postoperative 84.12±11.33. All patients’ G/L ratio were larger than1.50. Conclusions: The reverse sleeve of S-ROM was a simple and reliable method for patients with severe TVD, which brought satisfying clinical outcomes in mid-term follow-up. When G/L ratio is larger than 1.50, surgeons should consider this special surgical technique. Keywords: cementless modular stem; reverse sleeve; total hip arthroplasty; trochanter valgus deformity.
PLAC1 Enhances Metastatic Potential and is Associated with PI3K/AKT/NF-κB Signaling Pathway in Colon Cancer
Authors: Ma JIachi , Zhang Shoukai , Liang Danru , Li Lei , Du Jun , Pan Chengwu , Zhang Chensong , Chen Yuzhong 
Published: October 2019

Abstract
Background: To better explore the underlying mechanism of liver metastatic formation by placenta-specific protein 1 (PLAC1) in human colorectal cancer, we investigated the proliferation, invasion and angiogenic capabilities of human colorectal cancer cell lines with different liver metastatic potentials as well as the mechanism of action of PLAC1 in the metastatic process. Methods: The expression of PLAC1 was detected by reverse transcriptase PCR, western blot and real-time PCR. The effect of PLAC1 on metastatic potential was determined by proliferation, invasion, and angiogenesis assays, including an in vitro coculture system consisting of cancer cells and vascular endothelial cells that were used to detect the relationship between cancer cells and angiogenesis. In addition, we also determined PLAC1 downstream targets that preferentially contribute to the metastatic process. Results: PLAC1 was expressed in HT-29, WiDr and CaCo-2 colorectal cancer cells but not in Colo320 colorectal cancer cells. PLAC1 could not only significantly enhance the proliferation of CoLo320 and human umbilical vein endothelial cells (HUVECs) but could also promote the invasion of CoLo320 cells. The angiogenesis of HUVECs was enhanced by PLAC1 in a dose-dependent manner. In cocultured systems, angiogenesis was significantly increased by coculture with HT-29 cells. In addition, PLAC1 could promote angiogenesis in coculture with HT-29 cells. Furthermore, PLAC1-enhanced metastatic potential of colorectal cancer cells was dependent on activation of the PI3K/Akt/NF-κB pathway. Conclusions: The activation of PI3K/Akt/NF-κB signaling by PLAC1 may be critical for the metastasis of colorectal cancer cells. According to our results, we suggest that modification of PLAC1 function might be a promising new therapeutic approach to inhibit the aggressive spread of colorectal cancer.
Screening for tuberculosis infection in children and adolescents in Russia – past, present, future
Authors: Аksenova V. A. , Baryshnikova L. A. , Klevno N. I. , Kudlay D. A. 
Published: October 2019

The article presents a brief overview of the establishment and development of screening system in the pediatric population for tuberculosis and latent tuberculosis infection - from Koch alt-tuberculin to modern recombinant tuberculosis allergens for intradermal administration and in vitro laboratory tests. It gives extensive data on clinical research and the introduction into practical public health of the Russian Federation of the test with recombinant tuberculosis allergen as a screening method for tuberculosis in children from 8 to 14 years old inclusively.
Propensity to Sexual Response among Adults with Obsessive-Compulsive Disorder
Authors: Pozza Andrea , Marazziti Donatella , Mucci Federico , Dèttore Davide 
Published: October 2019

Background:
Propensity to sexual excitation and inhibition is one of the key dimensions of sexuality. Clinicians working with Obsessive-Compulsive Disorder (OCD) patients rarely assess this and other aspects of sexuality, since treatment targets generally symptom reduction. Literature on sexual functioning in OCD patients is scarce and no study has focused on symptom subtypes, nor investigated the psychological processes related to sexual response.

Objective:
In the present short report, we describe an exploratory study investigating the association between symptom subtypes and propensity towards sexual excitation/inhibition in OCD patients, controlling for gender, age and antidepressant treatment.

Methods:
Seventy-two OCD patients (mean age = 34.50 years, 37.50% women) completed the Obsessive-Compulsive Inventory-Revised and the Sexual Inhibition/Sexual Excitation Scales.

Results:
Patients with more severe compulsive washing habit had a lower propensity towards excitation and a higher one towards inhibition due to threat of performance consequences (i.e., contamination with sexually transmitted diseases/having an unwanted pregnancy). Patients with more severe symptoms of checking showed a higher propensity towards inhibition due to the threat of performance consequences. Gender, age and antidepressant treatment were not related to sexual functioning.

Conclusion:
Specific OCD symptom subtypes may be associated with some psychological processes involved in sexual response. Sexual well-being should be carefully evaluated by practitioners and should be regarded as a treatment target. Future studies should investigate more comprehensively the processes involved in sexuality.
Limitation Factors of Building Information Modeling (BIM) Implementation
Authors: Enshassi Mohammed A. , Al Hallaq Khalid A. , Tayeh Bassam A. 
Published: October 2019

Background:Building Information Modeling (BIM) has been recommended as the best tool to improve construction processes by many researchers. However, most construction companies do not adopt BIM because there are many limitations slowing BIM adoption.Objective:The aim of this paper is to investigate the factors that limit BIM implementation in the construction industry.Methods:To investigate the research objectives, a quantitative approach was adopted and a structured questionnaire was designed. A total of sixty-eight copies of the questionnaire were distributed and sixty-five of them were satisfactorily completed, making the total response rate = 95.58%. Snowball sampling method helped to obtain a high rate of response and thus increase accuracy.Results and Conclusion:BIM limitation factors were divided into five categories. The results illustrated that the personnel category was ranked as the most important, while the legal category was ranked as the least important. Findings showed that requirement of large culture change within the organization, lack of senior management support, lack of knowledge on how to implement BIM, lack of staff experience and skills, and need to change in workflows to comply with the new requirements were ranked as the most important factors that obstacle BIM implementation.
Direccionamiento estratégico en pequeñas fábricas del Clúster de la madera
Authors: Estrada López Hilda Helena , De la Cruz Almanza Sadan Alexander 
Published: October 2019

El propósito de la investigación se centra en analizar el direccionamiento estratégico de pequeñas fábricas del clúster de madera en el departamento del Atlántico, que enfrentan grandes retos de crecimiento y sostenibilidad en función del entorno donde se desenvuelven. Se fundamentó en un enfoque metodológico cualitativo, con un tipo de investigación explicativa, esencial para la explicación de las variables estudiadas y sus condiciones. Adicional a esto, la investigación se lleva a cabo a través de un estudio de casos, la población estuvo conformada por las microempresas fabricantes de muebles, y los informantes claves fueron 8 de ellas, las cuales se seleccionaron de manera intencional. Como herramienta de análisis se utilizó el modelo MMGO. Los resultados indicaron que los procesos de fabricación de muebles se ejecutan de forma Semi Industrial, sumado a esto, el manejo inadecuado de recursos, carencia de planificación, ordenamiento y una baja articulación del proceso, conlleva a presentar una baja competitividad. Así mismo, la implementación de un plan de estandarización de los procesos orientado al mejoramiento de la calidad de los productos. Se evidencia las debilidades significativas en sus procesos estratégicos, estructura organizacional y gestión humana, no obstante, han logrado sostener en un mercado competitivo y dinámico como es el sector muebles y madera a través de las herramientas que brinda el direccionamiento estratégico, se evidenció que las empresas por muy pequeñas que sean pueden desarrollar practicas organizacionales que le permitan ordenar sus funciones empresariales para hacer frente a las exigencias de mercado.
Diagnóstico sobre el nivel de generación de negocios inclusivos en la localidad de Kennedy en Bogotá y su impacto en el desarrollo local
Authors: Cabrera Jiménez Manuel Fernando 
Published: October 2019

A partir del reconocimiento de un nuevo paradigma generado en el periodo de posguerra, en el contexto del Nuevo Orden Mundial se desarrolló un enfoque denominado economía heterodoxa, donde el enfoque del bienestar social y el desarrollo humano cobra relevancia. De esta manera surgen nuevas corrientes de pensamiento en relación con el desarrollo, donde el hombre se asume como el centro de las relaciones económicas, en la búsqueda de un mejor nivel de prosperidad y crecimiento social incluyente, bajo este escenario surge el desarrollo local, basado en el fomento de capacidades individuales y colectivas, el cual se fortalece desde el reconocimiento de las particularidades culturales, capacidades económicas, experiencias productivas y recursos disponibles al servicio de un conglomerado social, el cual promueve la implementación de estrategias entre diferentes actores públicos y privados, manifestadas por acciones tales como los negocios inclusivos, los cuales en su cadena productiva involucran población de bajos ingresos o conocida como BdP. Frente a este panorama, este artículo asumió la Localidad de Kennedy en Bogotá, como contexto para conocer la percepción de los empresarios sobre negocios inclusivos, su capacidad para generarlos y el aporte que pueden tener frente al desarrollo local, identificándose que las empresas en términos generales aún, no comprenden las particularidades de esta estrategia y tienden a confundirla con acciones de responsabilidad social empresarial, de igual forma se evidencian alto nivel de desarticulación entre actores públicos, privados y ciudadanos; lo que complejiza aún más la posibilidad de generar negocios inclusivos en función del desarrollo local.
Does Using Accounting Data in Performance Evaluations Spoil Team Creativity? The Role of Leadership Behavior
Authors: Klein Aleksandra , Speckbacher Gerhard 
Published: October 2019

ABSTRACT
Organizations frequently use teams for creative problem-solving. Evaluating the performance of creative teams based on customer-related accounting data, such as client satisfaction measures, revenues, or profits, clarifies which kind of creativity is expected from the team and potentially makes the creative process more effective. However, the use of such accounting data in performance evaluations may amplify the tensions between the artistic merit and the commercial success of creative ideas and, thus, create conflicts that undermine team creativity. We argue that it depends on the team leader's leadership style whether the negative or positive effects of using customer-related data in performance evaluations on team creativity will prevail. If the team leader shows a leadership style that helps team members internalize the values and standards underlying the employed performance measures, then negative conflict inside the team is avoided and the positive effects of using customer-related data in performance evaluations can be realized.
Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes
Authors: Bril Fernando , McPhaul Michael J. , Caulfield Michael P. , Clark Virginia C. , Soldevilla-Pico Consuelo , Firpi-Morell Roberto J. , Lai Jinping , Shiffman Dov , Rowland Charles M. , Cusi Kenneth 
Published: October 2019

OBJECTIVE
The 2019 Standards of Medical Care in Diabetes suggested that patients with nonalcoholic fatty liver disease (NAFLD) should be evaluated for liver fibrosis. However, the performance of noninvasive clinical models/scores and plasma biomarkers for the diagnosis of nonalcoholic steatohepatitis (NASH) and advanced fibrosis has not been carefully assessed in patients with type 2 diabetes mellitus (T2DM).

RESEARCH DESIGN AND METHODS
In this cross-sectional study, patients (n = 213) had a liver MRS, and those with a diagnosis of NAFLD underwent a percutaneous liver biopsy. Several noninvasive clinical models/scores and plasma biomarkers were measured to identify NASH and advanced fibrosis (NASH: ALT, cytokeratin-18, NashTest 2, HAIR, BARD, and OWLiver; advanced fibrosis: AST, fragments of propeptide of type III procollagen [PRO-C3], FIB-4, APRI, NAFLD fibrosis score, and FibroTest).

RESULTS
None of the noninvasive tools assessed for the diagnosis of NASH in patients with T2DM had an optimum performance (all areas under the curve [AUCs] &lt;0.80). Of note, none of the panels or biomarkers was able to outperform plasma ALT (AUC 0.78 [95% CI 0.71–0.84]). Performance was better to diagnose advanced fibrosis, in which plasma PRO-C3, AST, and APRI showed better results than the other approaches (AUC 0.90 [0.85–0.95], 0.85 [0.80–0.91], and 0.86 [0.80–0.91], respectively). Again, none of the approaches did significantly better than plasma AST. Sequential use of plasma AST and other noninvasive tests may help in limiting the number of liver biopsies required to identify patients with advanced fibrosis.

CONCLUSIONS
Performance of noninvasive clinical models/scores and plasma biomarkers for the diagnosis of NASH or advanced fibrosis was suboptimal in patients with T2DM. Combination of multiple tests may provide an alternative to minimize the need for liver biopsies to detect fibrosis in these patients.
Caso clínico sobre encefalocele occipital primario
Authors: Vaca Diego , Lima Gabriela 
Published: October 2019

Los defectos del tubo neural (DTN) son defectos producidos por un cierre anormal de una porción del tubo neural entre la tercera y cuarta semana pos-concepcional. Pueden ser abiertos o cerrados. Los más comunes son mielomeningocele, anencefalia y encefalocele. La prevalencia en América es de 11,5 /100.000 nacimientos. El encefalocele definido como una protrusión del cerebro con o sin las meninges se presenta con una incidencia de 0,8-5/10.000 nacimientos. Sus causas principales son déficit de folatos, factores genéticos, síndromes y enfermedades metabólicas.
Se presenta el caso de una paciente de 22 años quien cursó un embarazo con controles preconcepcionales y prenatales deficientes; producto del cual a las 34 semanas de gestación mediante ecografía se detectó intra útero un feto de sexo femenino con un encefalocele occipital primario junto a otra malformación fetal (polidactilia).
Se decide el ingreso al servicio de alto riesgo obstétrico para diagnostico ecográfico definitivo en la unidad materno fetal y para observación, seguimiento y realización de una cesárea programada junto a la intervención multidisciplinar de los servicios de ginecología, neurocirugía, cardiología, psicología y genética. Se planifica cirugía de corrección del defecto luego de 15 horas de terminada la cesárea para estabilización de la recién nacida, el procedimiento termino sin complicaciones, la recién nacida pasa a unidad cuidados intensivos neonatales para cuidado post quirúrgico, donde a las 72 horas realiza hidrocefalia como complicación quirúrgica; la misma que se resuelve con la colocación de drenaje ventrículo peritoneal y a actualmente permanece en observación en neonatología sin complicaciones adicionales y en espera del alta.
Conclusiones. La importancia de la consulta preconcepcional en el embarazo es primordial para la determinación antes de la gestación de factores de riesgo que ocasionarían defectos o alteraciones prevenibles en el embarazo, los controles prenatales y las ecografías óptimas para la detección oportuna de malformaciones fetales toma una importancia real en la actualidad, la detección oportuna de los defectos fetales y el manejo multidisciplinario es de suma importancia en el pronóstico fetal de la malformación y la expectativa de vida de los recién nacidos.
REGIONAL EXPONENTIAL REDUCED OBSERVABILITY IN DISTRIBUTED PARAMETER SYSTEMS
Authors: AL-MULLAH Shahad , Al-Saphory Raheam 
Published: October 2019

The regional exponential reduced observability concept in the presence for linear dynamical systems is addressed for a class of distributed parameter systems governed by strongly continuous semi group in Hilbert space. Thus, the existence of necessary and sufficient conditions is established for regional exponential reduced estimator in parabolic infinite dimensional systems. More precisely, the introduced approach is developed by using the decomposed system and reduced system in connection with various new concepts of (stability, detectability, estimator, observability and strategic sensors). Finally, we also show that there exists a dynamical system for two-phase exchange system described by the coupled parabolic equations is not exponentially reduced observable in usual sense, but it may be regionally exponentially reduced observable.
Dufour and radiation effect on MHD boundary layer flow past a wedge through porous medium with heat source and chemical reaction
Authors: Pattnayak Hadibandhu , Mohapatra Rojali 
Published: October 2019

Magnetohydrodynamics (MHD) boundary layer flow past a wedge with the influence of thermal radiation, heat generation and chemical reaction has been analyzed in the present study. This model used for the momentum, temperature and concentration fields. The principal governing equations is based on the velocity in a nanofluid and with a parallel free stream velocity and surface temperature and concentration. The governing nonlinear boundary layer equations for momentum, thermal energy and concentration are transformed to a system of nonlinear ordinary coupled differential equations by using suitable similarity transformation with fitting boundary conditions. The transmuted model is shown to be controlled by a number of thermo-physical parameters, viz. the magnetic parameter, buoyancy parameter, radiation conduction parameter, heat generation parameter, Porosity parameter, Dufour number, Prandtl number, Lewis number, Brownian motion parameter, thermophoresis parameter, chemical reaction parameter and pressure gradient parameter. Numerical elucidations are obtained with the legendary Nactsheim-Swigert shooting technique together with RungeKutta six order iteration schemes.
Physics, Mechanics, Mathematics
Authors: Mahbod Mohammad 
Published: October 2019

Dynamics features movement and stable means. Continuous Stable dynamics thus means continuous movement or motion. That is a moving object which enjoys continuous movement. For example, the electron continuous revolution round the nucleus, the revolution of the moon round the earth and that of the earth round the sun. In this formula, the continuous movement of the moving object round the origin of coordinates in space is studied. Regarding the importance of the angular speed calculation in most of applied sciences such as dynamic mechanics , aerospace , dynamic systems and lock of a relation established in this connection , the need is felt that in order to design and optimize dynamic systems , a reasonable relation should be presented . This paper tries to prove such a relation in the easiest possible way.