bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polypeptidic Micelles Stabilized with Sodium Alginate Enhance the Activity of Encapsulated Bedaquiline
Authors: Soria‐Carrera Héctor , Lucía Ainhoa , De Matteis Laura , Aínsa José A. , de la Fuente Jesús M. , Martín‐Rapún Rafael 
Published: January 2019

AbstractThe coating of polypeptidic micelles with sodium alginate is described as a strategy to improve the stability of micelles for drug delivery. Bedaquiline, approved in 2012 for the treatment of multidrug resistant tuberculosis, has been used as an example of hydrophobic drug to study the loading efficiency, the release of the encapsulated drug in different media, and the in vitro antimicrobial activity of the system. Alginate coating prevents the burst release of the drug from micelles upon dilution and leads to a sustained release in all tested media. In view of possible oral administration, the alginate coated micelles show better stability in gastric and intestinal simulated media. Notably, the encapsulated bedaquiline shows increased in vitro activity against Mycobacterium tuberculosis compared to free bedaquiline.
Lubrication mechanisms of C‐MoS2‐Fe2O3 (Fe3O4) nano‐composite lubricants at the rubbing interfaces of non‐copper coated solid wires against the contact tube
Authors: Li Z.X. , Wan Q. , Li G.D. , Li H. , Li H.J. , Zhang T.L. , Kim H.J. , Tillmann W. 
Published: January 2019

AbstractGraphite‐MoS2‐Fe2O3 (Fe3O4) nano‐composite lubricating coatings were prepared on the surfaces of non‐copper coated solid wires by a mechanical coating technique. The tribological behaviours of graphite‐MoS2‐Fe2O3 (Fe3O4) coatings at the rubbing interfaces of welding wires against the contact tube were investigated. The results demonstrate that the lubricating properties of graphite‐Fe3O4 coatings outperform the lubricating properties of graphite‐Fe2O3 coatings. The anti‐wear performance of the contact tube is strengthened with increasing nano‐MoS2 contents. Layers of protective tribofilms are formed at the rubbing interfaces of welding wires against a contact tube by tribochemical reaction among lubricants. The tribofilms are composed of FeO, MoO3 and FeMoO4 with excellent lubricating properties. They can avoid direct contact of welding wires against the contact tube, thus decreasing contact tube wear. With the transition of the contact tube wear from mild to severe, the dominant wear mechanisms of contact tube change from fatigue peeling and oxidative wear to abrasive wear and arc ablation.
Vitamin D Protects Against Alcohol‐Induced Liver Cell Injury Within an NRF2–ALDH2 Feedback Loop
Authors: Zhang Hong , Xue Lian , Li Bingyan , Zhang Zengli , Tao Shasha 
Published: January 2019

ScopeAlcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Oxidative stress induced during the alcohol metabolism plays a crucial role in ALD, and clinical evidence demonstrates the prevalence and risks of vitamin D (VD) deficiency in ALD. This study aims to explore the mechanism of VD administration to ameliorate alcohol‐induced cell injury.Methods and resultsVD activates NRF2 (nuclear factor erythroid 2 (NF‐E2)‐related factor 2) signals along with upregulation of ALDH2 expression. Knockdown of NRF2 eliminates the protective effects of VD treatment. ALDH2 knockdown not only partially affects this protection, but also mildly reduces NRF2 expression. ALDH2 overexpression enhances ERK phosphorylation and upregulated NRF2 transcription via a newly identified TRE in the exon 1 of NRF2.ConclusionThis study provides evidence that VD protects against alcohol‐induced cell injury within an NRF2‐ALDH2 feedback loop. NRF2 induced by VD could transcriptionally upregulate ALDH2 expression to help metabolize alcohol. TRE‐driven transcriptional upregulation of NRF2 through ALDH2‐ERK/MEK signals would further exert the anti‐oxidant effects. The study explores a novel potential protection of VD in alcohol‐induced liver cell injury, and contributes to alcohol‐related liver disease nutritional therapies.
Effect of long‐term heat exposure on rheological and intrinsic water characteristics of bone‐derived beef stocks
Authors: Poulsen Cornelia Louise Nygaard , Clausen Morten Rahr , Gregersen Sandra Beyer , Bertram Hanne Christine 
Published: January 2019

AbstractBone‐derived protein stocks are used in food industry to enhance taste of soups, sauces, and a range of other products. Both during commercial manufacturing and when used for culinary purposes, the stocks may be exposed to high temperatures for an extended time period. The present study investigated the effect of retention at 90°C for 0, 3, 6, 9, 24, 48, 72, and 168 hr on the functional attributes of concentrated bone‐derived beef stocks (57% Dry matter (DM)). Visual inspection and rheological analyses showed that during increasing heat exposure, the gel strength as well as viscosity of the concentrated stocks decreased incrementally and significantly (P > 0.001). Nuclear magnetic resonance (NMR) relaxation measurements conducted on the beef stocks also revealed strong effects of heat exposure on the transverse (T2) relaxation time, which increased incrementally and significantly (P > 0.001) with longer heat exposure. Thus, the present study demonstrated that heat‐induced changes in rheological properties of bone‐derived beef stocks can be ascribed to changes in intrinsic water–protein interactions and water attributes as a result of heat‐induced protein modifications. In conclusion, the study proves that NMR relaxometry is a valuable tool for monitoring changes in intrinsic water mobility that are manifested in modified functional attributes of concentrated beef stocks.
International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function
Authors: Hashim Hashim , Blanker Marco H. , Drake Marcus J. , Djurhuus Jens Christian , Meijlink Jane , Morris Vikky , Petros Peter , Wen Jian Guo , Wein Alan 
Published: January 2019

IntroductionThe terminology for nocturia and nocturnal lower urinary tract function is reviewed and updated in a clinically and practically‐based consensus report.MethodsThis report has been created by a Working Group under the auspices and guidelines of the International Continence Society (ICS) Standardisation Steering Committee (SSC). All relevant definitions were updated on the basis of research over the last 16 years since the publication of the first nocturia standardization document in 2002. An extensive process of 16 rounds of internal and external reviews was involved to examine each definition exhaustively, with decision‐making by collective opinion (consensus).ResultsA clinically‐based terminology report for nocturia and nocturnal lower urinary tract function, encompassing five key definitions divided into signs and symptoms has been developed. Clarity and user‐friendliness have been key aims to make it interpretable by healthcare professionals and allied healthcare practitioners involved in the care of individuals with nocturnal lower urinary tract function.ConclusionA consensus‐based terminology report for nocturia and nocturnal lower urinary tract function has been produced to aid clinical practice and research.
Identifying Critically Ill Veterans Who Require Nutrition Intervention: A Quality Improvement Study Comparing Nutrition Risk Tools
Authors: Hiller Lynn D. , Metzger Lauri S. 
Published: January 2019

AbstractBackgroundIdentification of intensive care unit (ICU) patients who require nutrition intervention is crucial to initiating nutrition therapy. This prospective quality improvement study evaluated the Nutritional Risk Screening (NRS) 2002, Malnutrition Universal Screening Tool (MUST), and Nutrition Risk in Critically Ill (NUTRIC) score in comparison with the Veterans Administration Nutrition Status Classification (VANSC) tool to determine which best identified the need for nutrition intervention.MethodsA convenience sample of 150 ICU patients was evaluated using the VANSC, NRS 2002, MUST, and the NUTRIC score. The resultant score, need for nutrition intervention, and presence of malnutrition were recorded for patients. Interventions were defined as need for enteral or parenteral nutrition, nutritional supplements, or diet change. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Matthews Correlation Coefficient (MCC), F1 score, and accuracy to predict need for nutrition intervention were calculated for each screening tool.ResultsOf the 150 patients, 49 (33%) required 1 or more nutrition interventions. The NRS 2002 (0.878) and VANSC (0.816) had the highest sensitivity. The NUTRIC (0.921) and VANSC (0.911) had the highest specificity. The VANSC (0.816) and MUST (0.687) had the highest PPV. The VANSC (0.911) and NRS 2002 (0.872) had the highest NPV. The VANSC (0.727) and MUST (0.528) had the highest MCC. The VANSC (0.816) and MUST (0.680) had the highest F1 score.ConclusionsTrialing several tools to identify their efficacy and reliability individual setting may help determine the most appropriate tool to utilize for your patient population and specific goals.
Improved Nutrition Status in Patients With Advanced Heart Failure Implanted With a Left Ventricular Assist Device
Authors: Genev Ivo , Yost Gardner , Gregory Mary , Gomez Kayéromi , Pappas Patroklos , Tatooles Antone , Bhat Geetha 
Published: January 2019

AbstractBackgroundLeft ventricular assist device (LVAD) implantation for advanced heart failure is known to improve survival, functional capacity, and quality of life. Most patients implanted with LVADs suffer from moderate to severe malnutrition and deconditioning due to their advanced disease. The Mini Nutritional Assessment (MNA) and the short form of the survey (MNA‐SF) are 2 well‐validated clinical tools, previously used to assess patient nutrition status in numerous conditions. Earlier work has demonstrated that low nutrition scores can independently predict mortality in the LVAD population. This study explored changes in MNA scores and other clinical markers following LVAD.MethodsThis retrospective study included 74 patients implanted with LVADs between 2012 and 2017. MNA or MNA‐SF along with other clinical data and nutrition indices were assessed during the preoperative workup and reassessed on average 423.9 days post LVAD. Paired‐samples t‐tests were used to evaluate any changes.ResultsDespite an average body mass index of 30.8, 28.3% of patients were classified by MNA as malnourished, and 58.5% were considered at risk prior to LVAD implantation. Post LVAD implantation, MNA scores improved from an average of 19.2–23.0 (P < 0.001), with now only 3.8% classified as malnourished and 45.3% classified as at risk. MNA‐SF and prognostic nutritional index also improved significantly.ConclusionsThis study indicates that LVAD implantation is associated with a long‐term improvement in nutrition status when compared with the preoperative heart failure state.
‘Waiting for Jardiwanpa’: History and Mediation in Warlpiri Fire Ceremonies
Authors: Curran Georgia 
Published: January 2019

ABSTRACTWarlpiri fire ceremonies, including Jardiwanpa, have been documented in various ethnographies and films for over 100 years. Focused on the documented history of these rituals in Yuendumu, and through ethnographic observations from recent decades, I analyse the transforming meanings of fire ceremonies in contemporary Warlpiri lives. I demonstrate that there have been post‐settlement shifts in ritual purpose due to sedentarisation and the increased connections that Warlpiri people have made to a broader world. I note in particular that, when monetary payment for performing Jardiwanpa for filmic representation became standard practice in the 1990s, the intricacies of the Dreaming were no longer central, nor were the original purposes of conflict resolution and the opening up of marriage restrictions. Several films have been made of fire ceremonies, resulting in fixed representations of what otherwise are emergent practices. This has impacted the ways in which these rituals can be held today, and Warlpiri people have had to creatively re‐negotiate a space for Jardiwanpa and similar fire ceremonies.
Simultaneous Occurrence of Nanospheres and Nanofibers Self‐Assembled from Achiral Tripeptides
Authors: Vardhishna Malapaka Venkata , Srinivasulu Gannoju , Harikrishna Adicherl , Thakur Suman Siddharth , Chatterjee Bhaswati 
Published: January 2019

AbstractThe achiral tripeptide Boc‐Aib‐MABA‐Aib‐OMe has the ability to co‐exist as nanospheres and as a network of nanofibers in methanol. Furthermore, AFM and TEM images show the presence of bulges in the network of nanofibers. Interestingly, the formation of nanofibers is seen to emerge from the outer boundary of the spherical structures. Some of the nanofibers curl up at the tip and later result in the formation of hollow nanospheres with thick boundaries. The presence of β‐turn‐like structures with hydrogen bonding is observed using FT‐IR studies. The presence of hydrogen bonding is also demonstrated by using NMR studies.
Economic questions on global warming during the Trump years
Authors: Seo S. Niggol 
Published: January 2019

This paper examines the rapid changes made on U.S. climate change policies and regulations under the Trump administration for the past 22 months since his inauguration in January 2017. Policy changes are made on a wide range of climate‐related programs: Paris Agreement, Green Climate Fund, Clean Power Plan, CAFÉ automobile emission standards, arctic drilling, methane rule, and farm animal emissions. This paper discusses that Trump effects will soon be observed by several empirical indicators.
Wood and roots of major grapevine cultivars and rootstocks: A comparative analysis of stilbenes by UHPLC‐DAD‐MS/MS and NMR
Authors: Gabaston Julien , Leborgne Cécile , Waffo‐Teguo Pierre , Valls Josep , Palos Pinto Antonio , Richard Tristan , Cluzet Stéphanie , Mérillon Jean‐Michel 
Published: January 2019

AbstractIntroductionGrapevine wood and roots are by‐products obtained during vineyard management. This plentiful biomass is known to be rich in stilbenes and can be used as a source of high‐value compounds as well as active natural extracts. However, the stilbenes in grapevine wood and roots from different cultivars and rootstocks remain to be characterized.ObjectiveThe present study investigated the stilbene content of eight major Vitis vinifera cultivars and six different rootstocks. In addition, the distribution of stilbenes was established for each of seven parts into which the plants were sub‐divided.MethodologyFor stilbene characterization and quantification purposes, an ultra‐high performance liquid chromatography‐diode array detector‐mass spectrometry (UHPLC‐DAD‐MS/MS) analysis of different samples was carried out. Moreover, structural data of stilbenes was unambiguously studied by nuclear magnetic resonance (NMR) spectra.ResultsWhatever the cultivar/rootstock combination, stilbenes were found to be oligomerized from the aerial part to the root system. Furthermore, stilbene content varied widely depending on the cultivars and rootstocks. For instance, the cultivars Merlot, Tannat and Gamay noir were the richest in stilbenes while the rootstocks Gravesac, Fercal and 3390C contained the highest amounts.ConclusionThese findings provide insight into the knowledge that major grapevine cultivars and rootstocks can be used as a potential source of complex stilbenes.
Use of Cangrelor as a Bridge to Left Ventricular Assist Device Implantation in a Patient with a Recent Drug‐Eluting Stent Who Developed Acute Tirofiban‐Related Thrombocytopenia
Authors: Kabadi Rajiv A. , Danelich Ilya M. , Entwistle John W. , Marhefka Gregary D. , Reeves Gordon , Boyle Andrew J. , Qureshi Ataul M. 
Published: January 2019

Current guidelines emphasize the need for at least 6–12 months of oral dual antiplatelet therapy consisting of aspirin and a P2Y12 inhibitor following drug‐eluting coronary artery stent implantation. In patients with recently implanted coronary artery stents who require urgent cardiac or noncardiac surgery, the benefits of maintaining oral dual antiplatelet therapy must be carefully weighed against the risks of excessive bleeding, and current practice is largely guided by individual surgeon preferences. When the effects of a second oral antiplatelet agent are undesirable during the perioperative period, the use of a short‐acting intravenous antiplatelet agent as “bridge” therapy that can be discontinued shortly before surgery is associated with a reduced occurrence of adverse clinical events in patients with recently implanted coronary stents requiring urgent coronary artery bypass graft surgery. Cangrelor is an intravenous adenosine triphosphate analog P2Y12 receptor antagonist with a short plasma half‐life that has been used off label in patients with recent coronary stents as a bridge to invasive procedures with excessive bleeding risk. To our knowledge, this is the first case report to demonstrate the safe and effective use of cangrelor as a bridge to left ventricular assist device implantation in a patient with a recently implanted drug‐eluting coronary artery stent who developed acute thrombocytopenia following reexposure to tirofiban, a glycoprotein IIb/IIIa inhibitor.
Improving reporting of meta‐ethnography: The eMERGe reporting guidance
Authors: France Emma F. , Cunningham Maggie , Ring Nicola , Uny Isabelle , Duncan Edward A. S. , Jepson Ruth G. , Maxwell Margaret , Roberts Rachel J. , Turley Ruth L. , Booth Andrew , Britten Nicky , Flemming Kate , Gallagher Ian , Garside Ruth , Hannes Karin , Lewin Simon , Noblit George W. , Pope Catherine , Thomas James , Vanstone Meredith , Higginbottom Gina M. A. , Noyes Jane 
Published: January 2019

The aim of this study was to provide guidance to improve the completeness and clarity of meta‐ethnography reporting. Evidence‐based policy and practice require robust evidence syntheses which can further understanding of people's experiences and associated social processes. Meta‐ethnography is a rigorous seven‐phase qualitative evidence synthesis methodology, developed by Noblit and Hare. Meta‐ethnography is used widely in health research, but reporting is often poor quality and this discourages trust in and use of its findings. Meta‐ethnography reporting guidance is needed to improve reporting quality. The eMERGe study used a rigorous mixed‐methods design and evidence‐based methods to develop the novel reporting guidance and explanatory notes. The study, conducted from 2015 to 2017, comprised of: (1) a methodological systematic review of guidance for meta‐ethnography conduct and reporting; (2) a review and audit of published meta‐ethnographies to identify good practice principles; (3) international, multidisciplinary consensus‐building processes to agree guidance content; (4) innovative development of the guidance and explanatory notes. Recommendations and good practice for all seven phases of meta‐ethnography conduct and reporting were newly identified leading to 19 reporting criteria and accompanying detailed guidance.The bespoke eMERGe Reporting Guidance, which incorporates new methodological developments and advances the methodology, can help researchers to report the important aspects of meta‐ethnography. Use of the guidance should raise reporting quality. Better reporting could make assessments of confidence in the findings more robust and increase use of meta‐ethnography outputs to improve practice, policyand service user outcomes in health and other fields. This is the first tailored reporting guideline for meta‐ethnography.This article is being simultaneously published in the following journals: Journal of Advanced Nursing, Psycho‐oncology, Review of Education, PLoS One and BMC Medical Research Methodology.
Cellulose‐Supported CuI‐Nanoparticles‐Mediated Green Synthesis of Trifluoromethylbenzoate‐Linked Triazoles for Pharmacological & DFT study
Authors: Deswal Sonal , Tittal Ram Kumar , Yadav Pinki , Lal Kashmiri , Vikas D. Ghule , Kumar Nikhil 
Published: January 2019

AbstractA green heterogeneous catalyst cellulose‐supported CuI‐nanoparticles employed for efficient synthesis of 4‐trifluoromethylbenzoate‐linked triazole in high yield from 4‐trifluoromethyl‐benzoic acid prop‐2‐ynyl ester and aryl/benzyl azide under aqueous condition. All triazoles were successfully characterized by IR, 1H‐NMR, 13C‐NMR, HRMS and finally supported by X‐ray crystallographic structure of 4‐trifluoromethyl‐benzoic acid 1‐phenyl‐1H‐[1,2,3]triazol‐4‐ylmethyl ester. Antibacterial study revealed that triazoles substituted by 4‐NO2 and 4‐Cl group to the benzyl and benzene ring displayed good to comparable activity as compare to commonly used drug ciprofloxacin. Likewise, triazoles substituted with a 4‐NO2 group on benzyl ring, unsubstituted aryl and 4‐F substituted aryl showed better antifungal activity when compared with commonly used antifungal drug fluconazole. Further, the computational study by DFT (B3PW91) level with 6–311G(d,p) basis set studied chemical reactivities, chemical hardness and molecular stability of triazole by frontier molecular orbital and molecular electrostatic potential study. The DFT results were in good agreement with pharmacological studies.
Optimization of Chemi‐adsorption, EDLC, and Redox Capacitance Through Electro‐precipitation Synthesis of Fe3O4/NiO@rGO/h‐BN for the Development of Hybrid Supercapacitor
Authors: Saha Sanjit , Jang Wooree , Murmu Naresh C , Koo Hyeyoung , Kuila Tapas 
Published: January 2019

Abstract3D Fe3O4/NiO was grafted on to the 2D rGO/h‐BN by electro‐precipitation method. Nitrogen of h‐BN moiety and oxygen functional groups of rGO played the role of negative active site to trap the metallic cations. Electrochemical charge storage mechanism was optimized by controlling the stoichiometry and defect contents of Fe3O4/NiO@rGO/h‐BN. Stoichiometry of the electro‐precipitated samples was tailored in presence of negative active sites of rGO/h‐BN and applied D.C. bias of the electrochemical bath. In addition, the nucleation and growth of metal oxides were influenced by the stacking and vacancy defects of rGO/h‐BN sheets. High specific capacitance (1328 F g−1) of Fe3O4/NiO@rGO/h‐BN was attributed to the synergistic effect of electrochemical double layer capacitance of rGO, chemi‐adsorption of –OH ions on Lewis acid (boron of h‐BN moiety) and redox capacitance of Fe3O4/NiO in alkaline medium. In addition, the presence of pyrrolic defect at the rGO/h‐BN stacking region acted as the nucleation site and provided additional redox capacitance by shifting the Fermi level towards the valance band. An asymmetric supercapacitor (ASC) was constructed using Fe3O4/NiO@rGO/h‐BN and thermally reduced GO as positive and negative electrode, respectively. ASC showed high energy (82 W h Kg−1) and power density (5600 W Kg−1) along with low relaxation time constant (2.2 ms) and high stability (79%) after 10,000 charge discharge cycles.