bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Growing Young” in Australian Baptist Churches: Surveying Formation, Belonging and Mission
Authors: Cronshaw Darren 
Published: May 2019

Abstract
Australian Baptist Churches are seeking to respond to the broader trend of increasing disengagement of young people from church and faith. This article discusses Australian Baptist perspectives on generational ministries from the 2016 National Church Life Survey and interviews of generational pastors and young adults. In conversation with Fuller Youth Institute’s research, it explores how churches are “growing young”: fostering spiritual formation and discipleship with a range of spiritual practices; cultivating relationships and belonging including less “siloed” and more “generational” connections; and catalysing holistic mission including faith-sharing, community service and creation care.
Bringing China to Java
Authors: Post Peter 
Published: May 2019

Abstract
This paper discusses the paramount role of the Oei Tiong Ham Concern (OTHC) of Semarang in the “Buy Chinese Products” movement of the Republican Government during the period 1928–1937 and its attempts to control Java’s sugar trade with China during the same period. In doing so, the paper focuses on the personal relations between Chen Kung-po (Chen Gongbo), the Republican Minister of Trade and Industry, and the OTHC leadership, as well as the close collaboration between the Dutch-educated Peranakan and Totok Chinese business elites of Java in intensifying economic relations between China and Java. The paper thereby reassesses long-held views about attitudes and economic roles of the Westernized Peranakan Chinese elites and questions the usefulness of simplified political frameworks in analyzing the complex dynamics of intra-Asian trade and commerce in the highly politicized business environment of the 1930s.
Merenptah und Amenmesse: Entwurf einer alternativen Chronologie
Authors: Bányai Michael 
Published: May 2019

Abstract
Die Frage nach der chronologischen Position von Amenmesse innerhalb der späten 19. Dynastie ist ungeachtet aller Versuche einer Klärung weiterhin eine stark debattierte Angelegenheit geblieben. Man konnte von bisher zwei grundsätzlichen Lösungsansätzen Amenmesse zu unterbringen, sprechen. Der vorliegende Artikel möchte, angesichts der vom Autor festgestellten Schwierigkeiten der bisherigen Versuche, die Regierungszeit von Amenmesse chronologisch zu unterbringen, einer weiteren, dritten Alternative, nachgehen. Diese zieht in Betracht—in Übereinstimmung mit der Aussage der Historien von Manetho—die Möglichkeit eines Aufstands von Amenmesse während der späteren Regierungszeit Merenptahs. Ebenso wird hier zum ersten Mal die Aussage der Elephantine Stele des Sethnacht sowie von pHarris I auf diese Periode bezogen.
Covariance of Optimal Parameters of an Arctic Sea Ice–Ocean Model
Authors: Sumata Hiroshi , Kauker Frank , Karcher Michael , Gerdes Rüdiger 
Published: May 2019

Abstract
The uniqueness of optimal parameter sets of an Arctic sea ice simulation is investigated. A set of parameter optimization experiments is performed using an automatic parameter optimization system, which simultaneously optimizes 15 dynamic and thermodynamic process parameters. The system employs a stochastic approach (genetic algorithm) to find the global minimum of a cost function. The cost function is defined by the model–observation misfit and observational uncertainties of three sea ice properties (concentration, thickness, drift) covering the entire Arctic Ocean over more than two decades. A total of 11 independent optimizations are carried out to examine the uniqueness of the minimum of the cost function and the associated optimal parameter sets. All 11 optimizations asymptotically reduce the value of the cost functions toward an apparent global minimum and provide strikingly similar sea ice fields. The corresponding optimal parameters, however, exhibit a large spread, showing the existence of multiple optimal solutions. The result shows that the utilized sea ice observations, even though covering more than two decades, cannot constrain the process parameters toward a unique solution. A correlation analysis shows that the optimal parameters are interrelated and covariant. A principal component analysis reveals that the first three (six) principal components explain 70% (90%) of the total variance of the optimal parameter sets, indicating a contraction of the parameter space. Analysis of the associated ocean fields exhibits a large spread of these fields over the 11 optimized parameter sets, suggesting an importance of ocean properties to achieve a dynamically consistent view of the coupled sea ice–ocean system.
Benzodiazepines and non-benzodiazepine hypnotics – impact of a cluster adopted protocol on primary care prescribing
Authors: Weatherburn Christopher J 
Published: May 2019

Background and Aims Reduction of benzodiazepines and non-benzodiazepine hypnotics (BZDs and Z-drugs) prescribing is a priority. Dundee, Scotland, has a total of 25 general practices, split into four clusters. The cluster with the highest recorded prescribing of BZDs and Z-drugs adopted a prescribing protocol that aimed to reduce such prescribing. This paper evaluates the impact of this protocol. Methods Quarterly prescribing data were obtained from Information Service Division, NHS Scotland from Q1 2015/16 to Q4 2017/18. Data were split into four clusters and standardised to Defined Daily Dose (DDDs) per 1000 registered patients. Interrupted time series (ITS) analysis was performed to assess prescribing one year after this protocol was introduced. Results There was a crude reduction in prescribing of BZDs and Z-drugs across all GP practice clusters, but this related to an ongoing downward trend in prescribing. Allowing for this, in the cluster that adopted the protocol, ITS revealed there was no significant reduction attributable to the intervention in prescribing of DDD equivalent doses (−0.4%, 95% CI: −7.2 to 7.6). Conclusions Introduction of a cluster-wide prescribing protocol did not provide significant reduction of prescribing. Although crude figures might suggest an improvement, ITS analysis revealed this not to be the case.
Whole-exome sequencing indicates FLG2 variant associated with leg ulcers in Brazilian sickle cell anemia patients
Authors: de Carvalho-Siqueira Gabriela Queila , Ananina Galina , de Souza Bruno Batista , Borges Murilo Guimarães , Ito Mirta Tomie , da Silva-Costa Sueli Matilde , de Farias Domingos Igor , Falcão Diego Arruda , Lopes-Cendes Iscia , Bezerra Marcos André Cavalcanti , da Silva Araújo Aderson , Lucena-Araújo Antônio Roberto , de Souza Gonçalves Marilda , Saad Sara Teresinha Olalla , Costa Fernando Ferreira , de Melo Mônica Barbosa 
Published: May 2019

Although sickle cell anemia results from homozygosity for a single mutation at position 7 of the β-globin chain, the clinical aspects of this condition are very heterogeneous. Complications include leg ulcers, which have a negative impact on patients’ quality of life and are related to the severity of the disease. Nevertheless, the complex pathogenesis of this complication has yet to be elucidated. To identify novel genes associated with leg ulcers in sickle cell anemia, we performed whole-exome sequencing of extreme phenotypes in a sample of Brazilian sickle cell anemia patients and validated our findings in another sample. Our discovery cohort consisted of 40 unrelated sickle cell anemia patients selected based on extreme phenotypes: 20 patients without leg ulcers, aged from 40 to 61 years, and 20 with chronic leg ulcers. DNA was extracted from peripheral blood leukocytes and used for whole-exome sequencing. After the bioinformatics analysis, eight variants were selected for validation by Sanger sequencing and TaqMan® genotyping in 293 sickle cell anemia patients (153 without leg ulcers) from two different locations in Brazil. After the validation, Fisher’s exact test revealed a statistically significant difference in a stop codon variant (rs12568784 G/T) in the FLG2 gene between the GT and GG genotypes ( P = 0.035). We highlight the importance of rs12568784 in leg ulcer development as this variant of the FLG2 gene results in impairment of the skin barrier, predisposing the individual to inflammation and infection. Additionally, we suggest that the remaining seven variants and the genes in which they occur could be strong candidates for leg ulcers in sickle cell anemia. Impact statement To our knowledge, the present study is the first to use whole-exome sequencing based on extreme phenotypes to identify new candidate genes associated with leg ulcers in sickle cell anemia patients. There are few studies about this complication; the pathogenesis remains complex and has yet to be fully elucidated. We identified interesting associations in genes never related with this complication to our knowledge, especially the variant in the FLG2 gene. The knowledge of variants related with leg ulcer in sickle cell anemia may lead to a better comprehension of the disease’s etiology, allowing prevention and early treatment options in risk genotypes while improving quality of life for these patients.
Prospective International Pilot Study Evaluating the Efficacy of a Self-Guided Contouring Teaching Module With Integrated Feedback for Transitioning From 2D to 3D Treatment Planning
Authors: Abugideiri Mustafa , Schreibmann Eduard , Switchenko Jeffrey , McDonald Mark W. , Beitler Jonathan J. , Curran Walter J. , Bruner Deborah , Patel Pretesh , Tigeneh Wondemagegnhu , Mijena Miressa , Tian Sibo , Dhabaan Anees , Esiashvili Natia , Liu Tian , Ali Arif N. 
Published: May 2019

PURPOSE Transitioning from two-dimensional to three-dimensional treatment planning requires developing contouring skills. Contouring atlases are excellent resources, but they do not provide users active feedback. Developing countries may not have many radiation oncologists experienced in three-dimensional planning to provide training. We sought to develop a standardized self-guided educational module with integrated feedback to teach contouring skills. METHODS AND MATERIALS All 18 oncology residents at Black Lion Hospital/Addis Ababa University in Ethiopia were trained to contour the level II lymph node station. Residents took a baseline pretest quiz, survey, and contouring evaluation. Residents then watched an instructional contouring lecture and performed three additional cases with integrated feedback by comparing their contours to gold-standard contours. Residents then took a post-training quiz, survey, and contouring evaluation. Paired t tests and analysis of variance were used for analysis. RESULTS Before training, the average number of total cases ever contoured was 2.4 and the average number of head and neck cases contoured was 0.5. Comfort with contouring improved from being “not at all comfortable” to “quite comfortable” after the 3-hour training ( P < .001). The standard deviation between the resident contours and gold standard improved from 72.6 cm3 (pretest) to 7.4 cm3 (post-test). The average percentage overlap with the gold-standard contours and Dice similarity coefficient improved with each case performed, from 27.7% and 0.26 (pretest) to 80.1% and 0.77 (post-test), respectively ( P < .001). After training, 16 of 18 (88.9%) residents produced a Dice similarity coefficient greater than 0.7, the threshold generally accepted for excellent agreement. CONCLUSION This self-guided teaching module was an effective tool for developing level II lymph node contouring skills by providing active feedback and resulted in improved user confidence and accuracy compared with a gold standard. This module can be expanded to other disease sites and countries to further facilitate transitioning to three-dimensional treatment planning in developing countries.
Sofosbuvir/Velpatasvir/Voxilaprevir for Previous Treatment Failures With Glecaprevir/Pibrentasvir in Chronic Hepatitis C Infection
Authors: Pearlman Brian , Perrys Michael , Hinds Andrew 
Published: May 2019

Objectives:
Chronic hepatitis C-infected patients who do not respond to nonstructural 5A inhibitor-containing regimens have few treatment options. It is unclear if patients who fail glecaprevir/pibrentasvir (G/P) (Mavyret) can be re-treated with sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) (Vosevi) because the latter's registration trials antedated the availability of the former.

Methods:
Adherent virologic failures to G/P were re-treated with 12 weeks of SOF/VEL/VOX, and all subjects underwent resistance testing at baseline and again with subsequent relapse.

Results:
Ninety-four percent of subjects achieved sustained virologic response with re-treatment, despite 90% of 31 subjects harboring nonstructural 5A inhibitor resistance-associated mutations at baseline.

DISCUSSION:
SOF/VEL/VOX is an effective regimen for virologic failures to G/P.
Remarkable electronic effect on the total stereoselectivity of the cycloaddition reaction of arylnitrile oxides with pyrrol-2-one derivatives
Authors: Guesmi A , Hamadi N Ben 
Published: May 2019

AbstractThe regiospecific 1,3-dipolar cycloaddition of 1,5-dihydropyrrol-2-one and arylnitrile oxides derivatives have been investigated. The asymmetric induction expected by the chiral centre of the 5-hydroxy-3-methyl-1,5-dihydropyrrol-2-one derivatives was very effective, single diastereoisomers anti-3 was formed. The diastereoselectivity was linked to the destabilization of the syn transition state as a result of the electrostatic repulsion between the hydroxy group of the dihydropyrrol-2-one derivatives and the atom oxygen of the dipole.
Influence of Joule Heating and Non-Linear Radiation on MHD 3D Dissipating Flow of Casson Nanofluid past a Non-Linear Stretching Sheet
Authors: Sreenivasulu Pandikunta , Poornima Tamalapakula , Reddy Nandanoor Bhaskar 
Published: May 2019

Abstract
Present analysis is to study the combined effects of viscous dissipation and Joule heating on MHD three-dimensional laminar flow of a viscous incompressible non-linear radiating Casson nanofluid past a nonlinear stretching porous sheet. Present model describes that flow generated by bi-directional non-linear stretching sheet with thermophoresis and Brownian motion effects. The governing nonlinear partial differential equations are transformed into a system of nonlinear coupled ordinary differential equations by similarity transformations and then solved by employing shooting method. The effects of the flow parameters on the velocity, temperature and concentration as well as the skin friction coefficient, Nusselt number and Sherwood number near the wall are computed for various values of the fluid properties. This study reveals that the temperature of Casson nanofluid increases with combination of viscous dissipation and Joule heating. Increasing thermophoresis parameter increases the species concentration of the nanoflow. The comparison of present results have been made with the published work and the results are found to be very good agreement.
Proposition 8 and Homophobic Bullying in California
Authors: Hatzenbuehler Mark L. , Shen Yishan , Vandewater Elizabeth A. , Russell Stephen T. 
Published: May 2019

BACKGROUND:
Bias-based bullying is associated with negative outcomes for youth, but its contextual predictors are largely unknown. Voter referenda that target lesbian, gay, bisexual, and transgender groups may be 1 contextual factor contributing to homophobic bullying.

METHODS:
Data come from 14 consecutive waves (2001–2014) of cross-sectional surveys of students participating in the California Healthy Kids Survey (N = 4 977 557). Student responses were aggregated to the school level (n = 5121). Using a quasi-experimental design, we compared rates of homophobic bullying before and after Proposition 8, a voter referendum that restricted marriage to heterosexuals in November 2008.

RESULTS:
Interrupted time series analyses confirmed that the academic year 2008–2009, during which Proposition 8 was passed, served as a turning point in homophobic bullying. The rate of homophobic bullying increased (blinear = 1.15; P &lt; .001) and accelerated (bquadratic = 0.08; P &lt; .001) in the period before Proposition 8. After Proposition 8, homophobic bullying gradually decreased (blinear = −0.28; P &lt; .05). Specificity analyses showed that these trends were not observed among students who reported that they were bullied because of their race and/or ethnicity, religion, or gender but not because of their sexual orientation. Furthermore, the presence of a protective factor specific to school contexts among lesbian, gay, bisexual, and transgender youth (gay-straight alliances) was associated with a smaller increase in homophobic bullying pre–Proposition 8.

CONCLUSIONS:
This research provides some of the first empirical evidence that public campaigns that promote stigma may confer risk for bias-based bullying among youth.
Preparación y certificación de un Material de Referencia en densidad de agua ultra pura
Authors: Chavarría Sánchez Jessica 
Published: May 2019

La conductividad y dureza total en muestras de agua producida por cuatro combinaciones de equipos de purificación de agua fueron estudiadas. Se produjo agua ultrapura mediante diferentes métodos, eligiéndose la metodología que con que se obtuvieron muestras de agua con una conductividad y dureza total menor. Se llevaron a cabo varios procesos para la certificación de los materiales entre ellos: estudio de la conductividad en función del tiempo, el estudio del efecto de los procesos de llenado y envase, de asignación de valor de la densidad a cuatro temperaturas diferentes, utilizando métodos y variables de los estudios de estabilidad en las magnitudes de la conductividad y la densidad. Finalmente los resultados de la certificación fueron reportados en el certificado para el material de referencia certificado en densidad de los lotes de agua ultra pura
Método de ensayo para la determinación cualitativa y cuantitativa del contenido de polímero presente en ligantes asfálticos modificados
Authors: Salazar Delgado Jorge 
Published: May 2019

En Costa Rica, como en muchos países, se está implementando el uso de asfaltos modificados con polímeros en la construcción de carreteras, el mercado creciente ofrece varios tipos de polímeros que mejoran notablemente las propiedades reológicas de los asfaltos, comúnmente del tipo SBR, SBS, polvo de hule de llanta, EMA, EVA entre otros. Los porcentajes de modificación con respecto al ligante asfáltico están entre el 1% al 5% m/m. Sin embargo, a pesar del hecho anterior, poca investigación se ha realizado en la cuantificación de la cantidad de polímero incorporado en el ligante asfáltico.En consecuencia, el presente estudio pretende revisar los métodos para determinar, de forma cuantitativa y cualitativa, la presencia de polímeros presentes en el ligante asfáltico. Este artículo está dirigido principalmente a los laboratorios de ensayo que ejecutan ensayos a ligantes asfálticos y sus derivados, pero también a los ingenieros y profesionales que trabajan en la construcción de obras viales y en su control de calidad
Efecto de los materiales de coronamiento en la resistencia a la compresión de cilindros de concreto
Authors: Rodríguez Einer 
Published: May 2019

El objetivo de esta investigación es evaluar la relación entre el tipo de coronamiento de los especímenes cilíndricos de concreto y su respectivo valor final de esfuerzo a la compresión, de tal forma que permita determinar el cumplimiento según el método utilizado. Se estudian tres métodos posibles para preparar las caras de los cilindros, la primera consiste en colocar una mezcla formada de yeso-cemento a especímenes endurecidos, la segunda es colocar una mezcla elaborada con cemento Portland a especímenes frescos y la última se refiere a preparar las caras de los especímenes endurecidos mediante pulido. Como punto de comparación principal se tienen los cilindros con caras pulidas, considerados los elementos más representativos, dado que la carga de falla se aplica directamente al espécimen, posteriormente se analizan los resultados de compresión de los demás elementos. Como resultado final de la investigación, no hay una diferencia significativa en el valor de resistencia a la compresión inconfinada, por tanto los tres métodos para preparar las caras de los cilindros son aceptables
Interpretación a partir del análisis cinético de los resultados del ensayo acelerado (IRAM 1674) para la reacción álcali-sílice pavimentos
Authors: Vila González Patricia Elizabet , Pereyra María Noel 
Published: May 2019

En este trabajo se presentan los resultados de expansión según el ensayo acelerado de la barra de mortero (IRAM 1674) hasta los 14 días de inmersión en solución agresiva y el análisis cinético según las recomendaciones RILEM AAR-2. El objetivo principal del trabajo es contribuir a la interpretación de los resultados del ensayo acelerado a partir del análisis del crecimiento de la expansión con la edad del ensayo (análisis cinético), otorgándole así mayor confiabilidad al ensayo. El análisis cinético consiste en ajustar por mínimos cuadrados los datos experimentales de expansión a un modelo de comportamiento conocido (modelo KAMJ), de dónde surgen los parámetros Lnk y M.
El cálculo de los parámetros cinéticos Lnk y M es un buen indicador para analizar el comportamiento de la reacción. Si bien en la bibliografía se propone un valor límite para Lnk de -6 (valores menores, agregados no reactivos y valores mayores agregados deletéreos), al analizar los datos experimentales, se observó que valores bajos de este parámetro podrían no estar asociados a un crecimiento asintótico de la expansión, y por lo tanto, presentar un comportamiento deletéreo. Se considera que el coeficiente Lnk/M es un buen indicador para evaluar el comportamiento del agregado. Sin embargo - para poder definir un valor límite para el coeficiente Lnk/M - resulta necesario establecer una correlación con los ensayos en primas de hormigón de larga duración (1año o más) o de la experiencia en campo de comportamiento del agregado.
LEGITIMACIÓN DE LAS ERT EN CIUDAD DE MÉXICO: UN ANÁLISIS CON EL ENFOQUE DE LA ACCIÓN PÚBLICA
Authors: Hernández Romero Yasmín 
Published: May 2019

El objetivo de este artículo consiste en analizar la regulación de las empresas de redes detransporte basadas en aplicaciones móviles (ert) en la Ciudad de México (CDMX), mediante el enfoque de la acción pública propuesto por Lascoumes y Le Galés (2014), basándose en documentos oficiales e hipertextos, reconstruyendo el proceso acontecido durante el periodo de 2013 a 2017, el cual permitió su operación legal. Se concluye explicando en cómo la configuración de la acción pública y el arreglo final establecido condujeron a la legitimación y legalización de las ERT.
EL SURGIMIENTO DEL PROBLEMA DE LA LIBERTAD EN LA MODERNIDAD BURGUESA. SU FORMULACIÓN EN LEIBNIZ
Authors: Ayala Saavedra Roberto 
Published: May 2019

Libertad y Determinismo definen los términos de un problema instalado en el centro del debate intelectual desde los inicios de la modernidad. Las relaciones entre la subjetividad y el mundo objetivo, la acción y la estructura, remiten al núcleo problemático, la principal cuestión de fundamentos, junto al de la historicidad de las ciencias sociales. El objetivo de este trabajo es examinar el abordaje y los aportes realizados en este campo por uno de los más grandes pensadores de la modernidad, G. Leibniz.