bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the residual stress distribution in SiCp/Al composites under thermal cycling conditions
Authors: Yao Junge G , Wang Qingping , Zhang Chao 
Published: November 2024

In this study, a three-dimensional random representative volume element model was constructed using the finite element method combined with Python script to investigate the residual stress distribution in SiCp/Al composites with varying volume fractions, particle shapes, and particle size under thermal cycling conditions. The model has two different particle morphologies: spheres and irregular polygons. The results show that the irregular polygonal SiC particles exhibit higher residual stresses than spherical particles before and after thermal cycling due to their complex load transfer pathways and higher stress concentration at particle corners, which makes them more consistent with the characterization of SiCp/Al composites under practical application conditions. As the volume fraction of SiC particles increases, the particle spacing decreases, hindering the release of thermal stresses through plastic deformation. Notably, the relief rate of residual stress reached 53% in the 12 vol% SiCp/Al composites, with the stress decreasing from 698 MPa to 328 MPa after 50 thermal cycles. In contrast, the reduction rate for 18 vol% composites is only 13% after thermal cycling. Furthermore, compared to larger particles (7.3 µm, 8.9 µm), the smaller particles (4.3 µm, 5.9 µm) exhibit a more uniform stress distribution and lower thermal stresses before and after thermal cycling. Consequently, our work provides a significant theoretical basis for the design and application of SiCp/Al composites, especially for the application of materials under extreme temperature changes.
A Survival Analysis of Rural-Urban Disparities in COVID-19 Vaccination Uptake in the United States
Authors: Datta Biplab Kumar , Jaremski Jennifer E. , Ansa Benjamin E. , Odhiambo Lorriane , Clary Catherine , Islam K. M. Monirul , Johnson J. Aaron 
Published: November 2024

Purpose Though urban-rural disparities in COVID-19 vaccination coverage was documented at a point of time, little is known on the evolution of vaccination uptake over time. This study, using individual level time-to-event data, intend to assess the differences in monthly progression of vaccination uptake among U.S. adults by urban/rural residence. Design Survival analysis. Setting Urban and rural areas in 29 U.S. states. Subjects 135,969 adults aged 18+ years. Measures Time (in months) to receive the first dose of COVID-19 vaccine since the U.S. Food and Drug Administration (FDA) Emergency Use Authorization of Pfizer-BioNTech- and Moderna- COVID-19 Vaccine in December 2020. Analysis Kaplan-Meier survivor functions and stratified Cox proportional hazard models were estimated for the event of being vaccinated by urban/rural residence for 25 months starting from December 2020. Monthly survival probabilities for urban- and rural- adults were further assessed within certain demographic and socioeconomic groups. Results We found a gradual divergence of COVID-19 vaccination uptake in favor of urban adults, which was robust across sex, age groups, race and ethnicity, education, and income levels. In April 2021, after vaccine eligibility was expanded, 42.2% adults in urban and 53.3% adults in rural areas were unvaccinated. While only 19.3% urban adults remained unvaccinated in December 2022, this rate was 32.5% among rural adults. Compared to their urban counterparts, rural adults were 0.77 (95% CI: 0.76 - 0.79) times as likely to receive the first dose of COVID-19 vaccine. Conclusions Time-to-event analysis of vaccination against COVID-19 indicated a lower uptake among rural adults, which was persistent across different demographic and socioeconomic groups.
Certified Child Life Specialists in Hospice and Palliative Care Organizations: A State of the Profession
Authors: Mangers-Deans Jennifer , Friedberg Alyssa , Downing Kimberly , Lindley Lisa C. 
Published: November 2024

Background Certified Child Life Specialists (CCLSs) provide developmentally appropriate psychosocial care to children to promote positive coping. However, little is known about the current professional landscape and opportunities for professional growth, especially in hospice and palliative care. Objectives To conduct a needs assessment among CCLS and examine the role in hospice and palliative care. Methods CCLSs were surveyed on their experience and needs in providing care in hospice and palliative care organizations. The online survey contained questions about demographics and work environment. The survey included multiple choice, yes/no, and open-ended questions. Descriptive statistics were generated from the survey items and comments/open-ended questions were coded and assessed for themes. Results Among the 191 respondents, most were females (96.3%), under 40 years of age (63.8%), Caucasian (87.4%), and non-Hispanic (95.3%) with under 12 years of full-time work experience (57.0%). CCLSs commonly worked in urban/suburban (67.5%) pediatric programs (62.3%) with clients ranging from perinatal (33.5%) to adult caregivers of children (60.2%). Themes from the open-ended questions were: (a) role clarification, (b) staffing, (c) funding, (d) training/education, (e) professionality, and (f) self-care. Conclusions Key insights into the profession, along with challenges and opportunities of working within the hospice and palliative care setting were identified. The findings highlighted the unique need for professional development among CCLSs.
Systemic therapy for non–clear cell renal cell carcinomas: A systematic review
Authors: Ara Balqees , Babar Anum , Atif Durkho , Ghafoor Bushra , Shah Mustafa , Abdullah Syed Maaz , Safi Danish , Kamran Amir 
Published: November 2024

Objective Renal cell carcinoma (RCC) is the most common kidney cancer, with clear cell RCC being the predominant subtype. However, non-clear cell RCC constitutes a significant proportion of cases, presenting distinct challenges in treatment due to its varied histological subtypes. Despite recent advancements, the optimal therapeutic approach for non-clear cell RCC remains uncertain due to limited high-quality evidence. This systematic review aims to evaluate the efficacy of systemic therapies in nccRCC subgroups. Data source A comprehensive literature search identified studies from 2010 to 2024, using PubMed and Clinicaltrials.gov databases focusing on clinical trials and treatment outcomes. Data summary Results highlight the evolving therapeutic landscape, with targeted agents and immunotherapy demonstrating promising anti-tumor effects. Notably, tyrosine kinase inhibitors (TKIs) such as sunitinib and mTOR inhibitors like temsirolimus have shown efficacy across different subtypes. Combination therapies, including immunotherapy-based regimens, have also shown favorable outcomes. immune checkpoint inhibitors such as nivolumab and pembrolizumab demonstrated encouraging antitumor activity. Furthermore, specific targeting of signaling pathways, such as the c-MET pathway, has demonstrated efficacy in certain PapillaryRCC. Conclusion While combination therapies, including immunotherapies, have shown positive outcomes, immune checkpoint inhibitors like nivolumab and pembrolizumab have demonstrated encouraging antitumor activity. Additionally, targeting the c-MET pathway has proven effective in certain papillary RCC. Further research is warranted to establish optimal treatment strategies and improve outcomes for patients with non-clear cell RCC. Systemic therapy for non-clear cell RCC is complex and evolving. Further research is needed to delineate optimal treatment strategies for different histological subtypes and improve patient outcomes.
Qualitative analysis of clinical pharmacy interventions in an inpatient leukemia service
Authors: AL-Hadaddin Rand , Mustafa Nour , Alyamani Ahmad , Faqeer Nour 
Published: November 2024

Introduction Leukemia, a complex hematological malignancy, requires a multidisciplinary treatment approach, with clinical pharmacists playing a crucial role. However, their involvement in clinical practice is not well-documented in the literature. This study aimed to examine the characteristics of clinical pharmacy interventions (CPIs) reported by clinical pharmacists. Method This retrospective study involved extraction of CPIs entered into a pharmacy documentation database “Quantifi®” between January 2019 and June 2023. These CPIs included direct clinical pharmacist interventions (DCPIs), detected medication errors (MEs) and adverse drug reactions (ADRs). Results A total of 6286 CPIs were extracted, of which DCPIs, MEs and ADRs accounted for 5701 (90.7%), 357 (5.7%) and 228 (3.6%) reports, respectively. The most prevalent DCPIs were drug therapy discontinuation (n = 1080, 18.9%). Antimicrobials were the most common medications associated with DCPIs (n = 1991, 34.9%). Physicians accepted 99.4% of DCPIs and 64.1% (n = 3656) of direct interventions were considered significant. Among detected MEs, antimicrobials were the most reported medications (n = 158, 44.3%), with pharmacy internal errors being the most prevalent cause of the events (n = 172, 48.2%). Among the reported ADRs, hematological reactions were the most common (n = 81, 35.5%), and antineoplastic agents were the most frequently associated medications with ADRs (n = 164, 71.9%). Conclusion This study highlights the crucial role of clinical pharmacists in managing leukemia patients, emphasizing their key interventions and ability to identify MEs and ADRs. Further research is needed to explore the clinical outcomes and financial impact of their involvement.
Estimates and trends in the global burden of glaucoma influenced by metabolic risk factors from Global Burden of Disease Study between 1990 to 2019
Authors: Chen Juan , Fan Hua , Yu Qingwen , Tang Ting , Tong Xuhan , Hu Siqi , You Yao , Zhang Shenghui , Chen Chen , Tang Jiake , Wang Hu , Fu Xinyan , Zhang Xingwei , Wang Mingwei , Cheng Yongran 
Published: November 2024

Purpose Glaucoma is an irreversible eye disease that causes blindness, which not only causes visual impairment and economic burden to patients, but also increases the social burden. This study aimed to estimate the global burden of glaucoma due to metabolic risk over the past 30 years. Methods The number and rate of deaths, disability-adjusted life years (DALYs), and age-standardized rates (ASRs) for metabolic risk factors-induced glaucoma were extracted. The estimated annual percentage changes (EAPCs) for ASRs were calculated using a generalized linear model with a Gaussian distribution to quantify the temporal trends in the global burden of metabolic risk factor-attributed glaucoma. The strength and direction of the association between the sociodemographic index (SDI) and the DALY rate were measured using Spearman's rank-order correlation. Results Approximately 0.07% of the global DALYs of glaucoma in 1990 were associated with metabolic risk factors, which increased to 0.1% in 2019. From 1990 to 2019, the global DALY cases of glaucoma caused by metabolic risk factors and the global burden of DALYs increased, whereas the DALY rate decreased with a higher SDI regional grade. The ASR of glaucoma disability loss years with a metabolic high risk increased with age, reaching the highest in the >85-year-old age group. Conclusion The burden of glaucoma caused by metabolic risk factors has increased over the past three decades, especially in regions with a low SDI and in old-age groups.
Comparison of refractive outcomes in patients following scleral fixated intraocular lens implantation with Yamane and Z-suture techniques
Authors: Simsek Metehan , Besek Nilay Kandemir , Kirgiz Ahmet , Ahmet Sibel , Atik Burcu Kemer , Tellioğlu Adem 
Published: November 2024

Purpose To compare visual and refractive outcomes in aphakic patients who underwent scleral fixated intraocular lens (SF-IOL) implantation with Yamane and Z-suture techniques. Design Retrospective study Methods Patients who underwent SF-IOL implantation with Yamane and Z-suture techniques due to aphakia between 2021 and 2023 were analyzed. Preoperative and postoperative 6. month best corrected visual acuity (BCVA-LogMAR), preoperative and postoperative spherical error, cylindrical error and postoperative mean absolute error (MAE), corneal endothelial and topographic parameters, 3 mm-6 mm pupil diameter corneal higher-order aberrations (HOAs) were evaluated. Results Seventy-seven eyes of 77 patients who underwent SF-IOL implantation with Yamane and Z-suture techniques were included in the study. Yamane technique was performed in 38 (49.4%) and Z-suture technique in 39 (50.6%) patients. Postoperative BCVA was 0.44 ± 0.40 in Yamane technique and 0.47 ± 0.44 in Z-suture technique ( p = 0.73). Postoperative MAE was 0.84 ± 0.70 D in Yamane technique, 1.02 ± 0.88D in Z-suture technique ( p = 0.33). Postoperative CCT-preoperative CCT (ΔCCT) was 3.76 ± 27.62 µm in Yamane technique and 3.02 ± 15.58 µm in Z-suture technique ( p = 0.88). A significant difference was found between Yamane and Z-suture techniques only in the ΔTrefoil value at 6-mm pupil diameter in corneal HOAs. ΔTrefoil was significantly lower in Yamane technique ( p = 0.04). Conclusion Except ΔTrefoil value at 6-mm pupil diameter, although no significant difference was found, corneal endothelial and topographic parameters were less affected in Yamane technique compared to Z-suture technique.
Plain Language Summary of Publication: A comparison of once-monthly and once-every-2-months injectable formulations of aripiprazole in people with schizophrenia
Authors: Citrome Leslie , Such Pedro , Yildirim Murat , Madera-McDonough Jessica , Beckham Clodagh , Jin Na , Watkin Suzanne , Zhang Zhen , Larsen Frank , Harlin Matthew 
Published: November 2024

The purpose of this summary is to explain key findings from a study that included people with schizophrenia, as described in two separate articles (see the ‘Further Information’ section for more details). The study compared a new formulation of aripiprazole, given as an injection once every 2 months, with a once‑monthly injection of aripiprazole.
Peer mentoring program through a digital platform for people with systemic sclerosis: A feasibility study
Authors: Chen Yen T , Shah Nirali , Alore Mary , Hicks Sheri , Vann Nadia , Hotz Stephanie , Pape Adam , Sabbagh Maya , Cunningham Melissa , Khanna Dinesh , Murphy Susan L 
Published: November 2024

Objective: People with systemic sclerosis (SSc or scleroderma), a rare chronic autoimmune disease, often face significant physical and emotional challenges. Peer mentoring, where someone with similar lived experiences offers guidance and support, shows promise in enhancing the well-being of recipients and may benefit individuals with systemic sclerosis. This study aims to evaluate the feasibility and potential health effects of peer mentoring through a digital platform for people with systemic sclerosis. Methods: We conducted a one-group study to evaluate a 16-week peer mentoring program for people with systemic sclerosis. Mentors and mentees were matched by demographics and systemic sclerosis characteristics. Feasibility was evaluated using Orsmond and Cohn criteria: recruitment, data collection, acceptability, available resources, and participant responses to the program. Perceptions and usability of the peer mentoring program through a digital platform were assessed at week 16 (post-program). The health effects of peer mentoring were measured at baseline, week 8, and week 16. Results: Five trained mentors and 15 mentees were enrolled. Each mentor was paired with 2–4 mentees. We found that peer mentoring through a digital platform was feasible, acceptable, and had good usability for both mentors and mentees. Mentees reported significantly less anxiety at week 16 ( p < 0.001). Other improvements in fatigue, pain interference, depressed mood, and resilience were observed, but did not reach statistical significance. Conclusion: The peer mentoring program through a digital platform was well-received. Results provided preliminary support for the feasibility and potential health benefits of peer mentoring to enhance well-being in people with systemic sclerosis. Findings lay the groundwork for future peer mentoring research in systemic sclerosis.
Effect of graphite additive on physical, mechanical, and wearing properties of Al2O3/E-glass/phenol formaldehyde hybrid composite grinding wheel
Authors: Tafere Amanuel Gebrekrstos , Gerezgiher Alula Gebresas , Tesfay Abrha Gebregergs 
Published: November 2024

The research was conducted to develop and assess the performance of composite grinding wheels enhanced with a graphite additive. These composite wheels were composed of aluminum oxide as abrasive and reinforcement material, E-glass as a reinforcement material, and phenolic resin as the matrix material. Various concentrations of graphite (4%, 8%, 12%, and 16% by weight) were incorporated into the composite formulations. Aluminum oxide, phenolic resin, and graphite were hand-stirred and combined. The mixture was then compressed at 94.4 MPa at room temperature, followed by heat treatment at 204°C for 50 min. The incorporation of graphite into Al2O3/E-glass/phenol formaldehyde composite grinding wheels significantly enhanced their mechanical properties and grinding performance. Increasing the graphite content up to 12 wt% in grinding wheels (GW3) resulted in a steady increase in density (from 1.9 g/cm³ to 2.1 g/cm³) and a corresponding decrease in porosity (from 16.5% to 3.6%) compared to the 4 wt% graphite-filled grinding wheels (GW1). Moreover, GW3 showed improvements in push-out strength by 60.6% (from 4.1 MPa to 6.57 MPa) and compressive strength by 15.7% (from 21.8 MPa to 25.17 MPa) compared to GW1. Wheels containing 16 wt% graphite (GW4) exhibited the lowest wear rate, reducing it by 89% (from 0.105 g/cm2 to 0.019 g/cm2) compared to GW1. These findings suggest that graphite incorporation is a promising approach for developing more durable and efficient grinding wheels, with the optimal graphite content for balancing strength and wear being 12 wt%.
Con: indwelling pleural catheters cause harm to patients
Authors: Adams Katie , Bhatnagar Rahul 
Published: November 2024

Indwelling pleural catheters (IPCs) have rapidly grown in popularity since their introduction for the management of recurrent pleural effusions. In malignant pleural effusions especially, there has been a shift away from measuring pleurodesis success and towards more patient-centred outcomes. Multiple randomised controlled trials have shown that despite lower rates of pleurodesis, symptom control and quality of life outcomes are comparable when compared to alternatives such as talc pleurodesis. IPCs have the added benefit of minimising inpatient hospital stays and reducing the need for recurrent pleural interventions, key priorities for patients with palliative disease. As a result, IPC treatment is associated with excellent patient satisfaction coupled with acceptably low complication rates. Furthermore, in patients with a short life expectancy they confer a cost benefit for the healthcare system.Far from causing harm, IPCs are now recommended as first-line treatment by current clinical guidelines. In malignant pleural disease, guidance advocates IPCs should be offered as a first-line option with the focus on patient priorities and preferences. Ultimately IPCs provide a safe, effective, ambulatory option for managing recurrent pleural effusions.
Effect of antenatal education on pregnant women`s knowledge, attitude and preferences of delivery mode
Authors: El-shrqawy Eman Hassan , Elnemer Amina , Mohamed Elsayed Hanan 
Published: November 2024

Abstract
Background
Childbirth is considered as the happiest action that occurs in any parent's life. Although childbirth is a natural process, the choice of delivery mode is one of the concerns of pregnant women. Consequently, the objective of this study to assess the effect of antenatal education on pregnant women`s knowledge, attitude, and preferences of delivery mode.

Methods
A quasi-experimental research design was utilized to achieve the study utilizing 140 purposive sample of pregnant women selected from antenatal outpatient clinics at the New Obstetrics and Gynecology Hospital in Mansoura, Egypt.

Results
The study findings reported that there was a significant improvement in total scores of the intervention group`s knowledge and attitude toward the modes of delivery, with a highly statistically significant difference (p < 0.001) at post-intervention compared to the control group.

Conclusion
Prenatal education sessions were linked to a significantly improved maternal outcome in terms of knowledge, attitude, and preferences for delivery mode (p < 0.001).

Trial registration
ClinicalTrials.gov, NCT06561984, registered on August 19, 2024, retrospectively registered.
Characteristic of mental health app usage: a cross-sectional survey in the general population
Authors: Fürtjes Sophia , Gebel Elisabeth , Kische Hanna , Beesdo-Baum Katja 
Published: November 2024

Abstract
Background
Mental health apps (MHA) have gained popularity in recent years. Most freely available apps are of low quality and lack evidence for effectiveness. Yet, download rates indicate high usage. MHA are potentially beneficial for individuals with no/low symptom severity as prevention, or as an option to reach underserviced populations. However, currently very little is known about the characteristics of MHA users in the general population, about the kind of MHA used, or the motivation behind MHA usage.

Methods
We collected survey-data from N = 1,247 individuals from the general population to investigate MHA usage.

Results
Descriptive statistics revealed that 41% had used MHA in the past 12 months; prescription app-use however was low (1.5% of MHA users). Mindfulness, moodtracking, and relaxation were the most popular categories of MHA. Perceived helpfulness, fun, and availability were the top reasons for MHA usage. Non-users reported distrust, lack of perceived need, and data security concerns as usage barriers. MHA users and non-users did not differ regarding sociodemographic variables. Multiple regression analyses revealed that sub-threshold symptoms of psychological disorders as well as higher levels of anxiety and stress were linked to higher probability of MHA usage. Higher levels of depression were associated with lower likelihood of MHA usage in general, but increased likelihood of usage of self-help apps specifically for depression.

Conclusions
It follows that MHA use is common in the general population independent of sociodemographic characteristics. MHA can reach people who might benefit, but more awareness and better structure of the market is needed to reduce distrust, increase usage of high-quality MHA, and improve the fit between app and user.