bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive and negative regulation of seed germination by the Arabidopsis GA hormone receptors, GID1a, b, and c
Authors: Ge Wenjing , Steber Camille M. 
Published: September 2018

AbstractEpistasis analysis of gid1 single and double mutants revealed that GID1c is a key positive regulator of seed germination, whereas the GID1b receptor can negatively regulate germination in dormant seeds and in the dark. The GID1 GA receptors were expected to positively regulate germination because the plant hormone gibberellin (GA) is required for seed germination in Arabidopsis thaliana. The three GA hormone receptors, GID1a, GID1b, and GID1c, positively regulate GA responses via GA/GID1‐stimulated destruction of DELLA (Asp‐Glu‐Leu‐Leu‐Ala) repressors of GA responses. The fact that the gid1abc triple mutant but not gid1 double mutants fail to germinate indicates that all three GA receptors can positively regulate non‐dormant seed germination in the light. It was known that the gid1abc triple mutant fails to lose dormancy through the dormancy breaking treatments of cold stratification (moist chilling of seeds) and dry after‐ripening (a period of dry storage). Previous work suggested that there may be some specialization of GID1 gene function during germination because GID1b mRNA expression was more highly induced by after‐ripening, whereas GID1a and GID1c mRNA levels were more highly induced by cold stratification. In light‐germinated dormant seeds, the gid1b mutation can partly rescue the germination efficiency of gid1a but not of gid1c seeds. Thus, GID1b can function as an upstream negative regulator GID1c, a positive regulator of dormant seed germination. Further experiments showed that GID1b can negatively regulate dark germination. Wild‐type Arabidopsis seeds do not germinate well in the dark. The gid1b and gid1ab double mutants germinated much more efficiently than wild type, gid1c, or gid1ac mutants in the dark. The observation that the gid1ab double mutant also shows increased dark germination suggests that GID1b, and to some extent GID1a, can act as upstream negative regulators of GID1c. Since the gid1abc triple mutant failed to germinate in the dark, it appears that GID1c is a key downstream positive regulator of dark germination. This genetic analysis indicates that the three GID1 receptors have partially specialized functions in GA signaling.
Monitoring nonlinear profile data using support vector regression method
Authors: Li Chung‐I , Pan Jeh‐Nan , Liao Chun‐Han 
Published: September 2018

AbstractIn today's manufacturing industries, if the quality characteristic of a product or a process is assumed to be represented by a functional relationship between the response variable and one or more explanatory variables, then the data generated from such a relationship are called profile data. Generally speaking, the functional relationship of the profile data rarely occurs in linear form, and the real data usually do not follow normal distribution. Thus, in this paper, the functional relationship of profile data is described via a nonparametric regression model and a nonparametric exponentially weighted moving average (EWMA) control chart is developed for detecting the process shifts for nonlinear profile data in the Phase II monitoring.We first fit the nonlinear profile data via a support vector regression model and use the fitted values to calculate the five metrics. Then, the nonparametric EWMA control chart with the five metrics can be constructed accordingly. Moreover, a simulation study is conducted to evaluate the detecting performance of the new control chart under various process shifts using the out‐of‐control average run length. Finally, a realistic nonlinear profile example is used to demonstrate the usefulness of our proposed nonparametric EWMA control chart and its monitoring schemes. It is expected that the proposed nonparametric EWMA control chart can enhance the monitoring efficiency for nonlinear profile data in the phase II study.
Coherence Time Analysis in Semiconducting Hybrid Qubit under Realistic Experimental Conditions
Authors: Ferraro Elena , Fanciulli Marco , De Michielis Marco 
Published: September 2018

AbstractThe unavoidable effect of the environmental noise due to nuclear spins and charge traps is included in the study of the hybrid qubit dynamics. Hybrid qubit owes its name to the advantageous combination of manipulation speed of a charge qubit with the longevity of a spin qubit. It consists of three electrons confined through external gate voltages in a double quantum dot and deserves special interest in quantum computation applications due to its advantages in terms of fabrication, control, and only electrical manipulation. The fluctuations of the global magnetic field do not affect the dynamics of the hybrid qubit that is defined in a decoherence‐free subspace. The main sources of decoherence come from local magnetic fluctuations and charge fluctuations. This work is based on the hypothesis that gate voltages are fixed and kept constant while qubit evolves in time. Coherence time of the hybrid qubit is extracted when model parameters take values achievable experimentally in the nuclear‐free isotope 28Si, natural Si, and GaAs hosts.
Tapping into the knowledge of incumbents: The role of corporate venture capital investments and inventor mobility
Authors: Di Lorenzo Francesco , van de Vrande Vareska 
Published: September 2018

Research SummaryThis article investigates the impact of corporate venture capital (CVC) investments and inventors' mobility on the extent to which new ventures use incumbents' knowledge resources as inputs for their innovation activities. Our findings suggest that ventures receiving CVC investments draw less on investors' knowledge, while inventor mobility increases the extent to which an incumbent's technological knowledge is used by recipient ventures. Ventures combining CVC investments and inventor mobility from the same incumbent are selected for drawing less on that incumbent's patents, but these citation flows increase in the period after investment and the inventors' hiring events are combined. Our results, thus, unveil the organizational complexity associated with the individual and combined roles of CVC investments and inventor mobility in determining new ventures' innovation behaviors.Managerial SummaryNew ventures often acquire resources from large established firms to foster development and success. Among others, research has primarily focused on equity investments—corporate venture capital and the hiring of employees—in particular inventors. While prior work has studied the impact of these two resources in terms of success and performance, we look more specifically at whether these two particular resources, individually and combined, could function as channels through which new ventures can access and use established firms' knowledge assets. Our analyses suggest that ventures receiving CVC investments draw less on investors' knowledge, while those hiring inventors draw more. Ventures combining these resources show an increased use of the incumbent firm's knowledge assets in the period after investment and hiring are combined.
Surface Engineering of Perovskite Oxide for Bifunctional Oxygen Electrocatalysis
Authors: Ou Gang , Yang Cheng , Liang Yuwei , Hussain Naveed , Ge Binghui , Huang Kai , Xu Yushuai , Wei Hehe , Zhang Ruoyu , Wu Hui 
Published: September 2018

AbstractPerovskite oxide, a low‐cost bifunctional oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) electrocatalyst, has acquired a rapidly growing research interest in the areas of energy conversion and storage, owing to its significant surface structure‐induced catalytic performance. Here, recent progress on the electrocatalytic performance of La0.6Sr0.4Co0.2Fe0.8O3–δ (LSCF) is built by engineering its surface defect structure through a versatile, effective, and controllable lithium reduction strategy. It is established that the lithium reduction treatment causes the formation of a structurally disordered layer at the surface of LSCF nanoparticles. The treated nanoparticles demonstrate significantly enhanced OER and ORR performance, especially for 5 wt% lithium‐reduced LSCF, whose OER potential decreases from 1.66 to 1.55 V at current density of 10 mA cm−2, and ORR onset potential increases from 0.70 to 0.84 V. This work provides the foundation for the optimization of catalytic performance of perovskite oxide (LSCF). Moreover, such defective materials are promising candidates for energy conversion and storage applications.
The Risk of Erectile Dysfunction Following Pelvic Angiographic Embolization in Pelvic Fracture Patients: A Nationwide Population‐Based Cohort Study in Taiwan
Authors: Hsu Sheng‐Der , Chen Cheng‐Jueng , Wang I‐Duo , Lin Kuen‐Tze , Wang Chia‐Chi , Chien Wu‐Chien , Chung Chi‐Hsiang , Chang Wei‐Kuo 
Published: September 2018

AbstractBackgroundPelvic fracture with hypovolemic shock is a known crucial injury in trauma patients. Pelvic fracture with vessel injury often leads to hemodynamic complications; in a trauma scenario, evidence of other systems being affected is often absent. Bleeding cessation and resuscitation are important for these types of trauma patients. For this purpose, pelvic angiographic embolization is frequently used. Multiple studies have reported that angiographic embolization may cause erectile dysfunction (ED) in hemodynamically stable patients with pelvic fracture. However, no study has evaluated a large patient cohort with a long‐term follow‐up. We hypothesized that angiographic embolization to control bleeding may compromise blood supply to the genitourinary organs or cause secondary neurogenic injury that increases the risk of ED. Our goal was to evaluate the risk of ED following pelvic fractures in male patients treated with pelvic angiographic embolization.MethodsWe used data from the National Health Insurance Research Database (NHIRD) from 1997 to 2010 provided by the Bureau of National Health Insurance of the Department of Health in Taiwan. We collected disease histories from inpatient files. The disease diagnoses were based on the International Classification of Diseases (ICD), Ninth Revision, Clinical Modification. These data were all deidentified, and we did not contact the patients. As such, informed consent was not needed.ResultsEighty‐five and 82,802 patients were included in the case and control cohorts, respectively. All patients were aged 15–45, and the proportion of pelvic fracture locations was equal between the groups. After investigating the causes of ED among male patients aged 15–45 with pelvic fractures using logistic regression analysis in a generalized estimating equations model and after adjusting for the influence of confounders, we found that these patients had high risks (odds ratio (OR): 32.637; 95% confidence interval: 14.137–75.346; P < 0.001) of developing ED post‐angiographic embolization.ConclusionsMale patients in Taiwan with pelvic fractures who undergo angiographic embolization to control bleeding have a higher risk of ED than those who do not undergo the procedure. Physicians should practice caution and inform patients of this connection before the procedure.
Understanding the Effect of a Paint Bake Cycle on the Microstructure–Mechanical Properties Relationship of a Resistance Spot Welded Advanced High Strength Steel
Authors: Eftekharimilani P. , van der Aa E. M. , Petrov R. , Hermans M. J. M. , Richardson I. M. 
Published: September 2018

Abstract
The effect of an automotive paint bake (PB) thermal cycle on the microstructural evolution and the mechanical properties of resistance spot welded advanced high strength steel is presented in this work. Mechanical behavior of the heat-treated welds reveals an increase in maximum cross-tension strength, displacement and subsequently energy absorption capability when 453 K (180 °C)-20 minutes a bake thermal cycle is applied after welding. The microstructures of resistance spot welds with and without a PB heat treatment were characterized using scanning and transmission electron microscopy (TEM). TEM analysis revealed that the weld nugget and HAZ of the resistance spot welds consist of a martensitic microstructure. The microstructural analysis of the post-weld heat-treated samples shows the presence of ε carbides in a martensitic matrix within the weld nugget and the HAZ. It is shown that the improved mechanical response of the paint-baked welds is associated with carbide precipitation during heat treatment.
PTMD: A Database of Human Disease-Associated Post-Translational Modifications
Authors: Xu Haodong , Wang Yongbo , Lin Shaofeng , Deng Wankun , Peng Di , Cui Qinghua , Xue Yu 
Published: September 2018

Abstract
Various posttranslational modifications (PTMs) participate in nearly all aspects of biological processes by regulating protein functions, and aberrant states of PTMs are frequently implicated in human diseases. Therefore, an integral resource of PTM–disease associations (PDAs) would be a great help for both academic research and clinical use. In this work, we reported PTMD, a well-curated database containing PTMs that are associated with human diseases. We manually collected 1950 known PDAs in 749 proteins for 23 types of PTMs and 275 types of diseases from the literature. Database analyses show that phosphorylation has the largest number of disease associations, whereas neurologic diseases have the largest number of PTM associations. We classified all known PDAs into six classes according to the PTM status in diseases and demonstrated that the upregulation and presence of PTM events account for a predominant proportion of disease-associated PTM events. By reconstructing a disease–gene network, we observed that breast cancers have the largest number of associated PTMs and AKT1 has the largest number of PTMs connected to diseases. Finally, the PTMD database was developed with detailed annotations and can be a useful resource for further analyzing the relations between PTMs and human diseases. PTMD is freely accessible at http://ptmd.biocuckoo.org.
Barlborough Hall, Derbyshire
Authors: Smith Pete 
Published: September 2018

AbstractThis article examines the architectural evolution of Barlborough Hall from its construction in 1583 to the present day, using a number of previously unpublished documents, mostly from the Locker-Lampson Collection. It also discusses a painting in the British Library which indicates that the house was once prefaced by ranges of forecourt buildings, and it outlines the various alterations made to the house and garden between 1696 and 1714, identifying the architect responsible for at least some of these changes as John Hallam. The most important source of new information is an album of drawings by Lindley, Woodhead & Hurst of 1815, which records the building in detail before further alterations completed in 1825. These drawings also permit reconstructions of the likely design and appearance of the original house. The relatively minor additions in the mid-nineteenth century and the alterations made to the building since it became a school in 1938 are also outlined.
‘A Stammering Bundle of Welsh Idealism’: Arthur Trystan Edwards and Principles of Civic Design in Interwar Britain
Authors: Shasore N.E. 
Published: September 2018

AbstractThis article provides the first account of key texts and concepts in the theory and criticism of Arthur Trystan Edwards. Edwards's notion of ‘civic design’, which emanated from the Liverpool School of Architecture in the second decade of the twentieth century, was part of a broader international trend (particularly in the US and Europe) towards formal, axial and monumental planning. Edwards imbued civic design with a philosophical and political sophistication that set him apart from many of his non-Modernist contemporaries. The article discusses the underlying precepts — such as ‘subject’, ‘form’, ‘urbanity’ and ‘manners’ — in some of Edwards's critical texts, includingGood and Bad Manners in Architecture(1924). The final section traces his pioneering interest in high-density, low-rise housing, which culminated with the establishment of the Hundred New Towns Association in 1933–34.
Delivery of the research participant perception survey through the patient portal
Authors: Kelly-Pumarol Issis J. , Henderson Perrin Q. , Rushing Julia T. , Andrews Joseph E. , Kost Rhonda G. , Wagenknecht Lynne E. 
Published: September 2018

IntroductionThe patient portal may be an effective method for administering surveys regarding participant research experiences but has not been systematically studied.MethodsWe evaluated 4 methods of delivering a research participant perception survey: mailing, phone, email, and patient portal. Participants of research studies were identified (n=4013) and 800 were randomly selected to receive a survey, 200 for each method. Outcomes included response rate, survey completeness, and cost.ResultsAmong those aged <65 years, response rates did not differ between mail, phone, and patient portal (22%, 29%, 30%,p>0.07). Among these methods, the patient portal was the lowest-cost option. Response rates were significantly lower using email (10%,p<0.01), the lowest-cost option. In contrast, among those aged 65+ years, mail was superior to the electronic methods (p<0.02).ConclusionsThe patient portal was among the most effective ways to reach research participants, and was less expensive than surveys administered by mail or telephone.
Identification of multiple natural and anthropogenic sources of dust in snow from Zhongshan Station to Dome A, East Antarctica
Authors: DU ZHIHENG , XIAO CUNDE , DING MINGHU , LI CHUANJIN 
Published: September 2018

ABSTRACTThe stable oxygen isotope composition, major ions and isotopic compositions of strontium (Sr), neodymium (Nd) and lead (Pb) in insoluble dust from recent surface snow samples along the transect from the Zhongshan and Progress stations (located on the Amery Ice Shelf, East Antarctica) to Dome A (Summit, Antarctica) were analysed. No previous isotopic fingerprinting studies have been conducted for this transect. These data were used to document the dust provenances in Antarctica along the transect up to the highest site, Dome A, for the first time. The insoluble dust in snow samples along the coast displays an overall crust-line isotopic signature that is characterised by highly radiogenic 87Sr/86Sr values and less radiogenic 143Nd/144Nd values. These signatures are comparable with those of samples collected near the ice-free areas of the Zhongshan and Progress stations. Spatial differences are statistically significant along the transect, and the Sr, Nd and Pb isotope components in insoluble dust from two continuous snow samples at Dome A exhibit marked differences, indicating that additional dust reaches the East Antarctic Plateau. The isotopic characteristics of insoluble dust from this transect indicate that the long-distance natural dust and anthropogenic pollutants in these samples primarily originate from Australia.
Spaces of Autonomy, Spaces of Hope: The place of the university in post-colonial Singapore
Authors: HOLDEN PHILIP 
Published: September 2018

AbstractThis article explores the background to and consequences of the resignation of B. R. Sreenivasan as the vice-chancellor of the University of Singapore in October 1963, after a public clash with the People's Action Party state government, led by Prime Minister Lee Kuan Yew. Sreenivasan's resignation has been the subject of radically different historical interpretations. It has been celebrated by some nationalist historians as part of a process of cultural decolonization, but criticized by others as precipitating a two-decades long erosion of academic freedom in Singapore. Careful attention to the event and its context, however, offers a powerful heuristic concerning the place of higher education in the process of decolonization, and the manner in which colonial universities came to be symbolic repositories of nationalism that enjoyed some degree of autonomy from the state. Debates on the role of the university that arose in Singapore after the resignation were plural, and diverse, and have much to teach us not only about the past, but also about a future in which international research universities such as the National University of Singapore embrace contradictory roles and yet still strive for new forms of academic autonomy.
Vicissitudes of Reality
Authors: Reinhardt Lloyd 
Published: September 2018

Abstract‘Real’ and ‘really’ are deflated and minimalized in parallel to the minimalist and de-flationary treatment of truth. J.L. Austin's insightful comment that with ‘real’: ‘The negative wears the trousers’ is elucidated and developed. There follows a discussion of the bearing of the point on Plato's claims about knowledge, belief and ignorance. It is maintained that it is implausible to hope that acquaintance with a Form for various Fs is going to provide complete knowledge of the wardrobe of Austinian trousers, especially inasmuch as that wardrobe grows and changes with the vicissitudes of socio-industrial-commercial-technological life.
What Is a Science of Religion?
Authors: Appiah Kwame Anthony 
Published: September 2018

AbstractModern sociology and anthropology proposed from their very beginnings a scientific study of religion. This paper discusses attempts to understand religion in this ‘scientific’ way. I start with a classical canon of anthropology and sociology of religion, in the works of E. B. Tylor (1832–1917), Max Weber (1864–1920) and Émile Durkheim (1858–1917). Science aims to be a discourse that transcends local identities; it is deeply cosmopolitan. To offer a local metaphysics as its basis would produce a discourse that was not recognizable as a contribution to the cosmopolitan conversation of the sciences. So, a science of religion cannot appeal to the entities invoked in any particular religion; hence the methodological atheism of these three founding fathers. This cosmopolitan ideal, the calling of the scientist, on the one hand, and the concern to understand the ideas of other cultures, on the other, can pull in different directions. Understanding requires us to appeal to our own concepts but not to our own truths. In the explanations, though, truth – the universal shared reality – has to matter, because the scientific story of religion has to work for people of all faiths and none, precisely because it is cosmopolitan. Not everything we call a religion will have historical Christianity's laser-like focus on ontological truth-claims. But as long as there are people making truth-claims in the name of religion, there will be the possibility of a tension between the very idea of a science of religion and some of the multifarious collections of beliefs, practices and institutions that make up what we now call ‘religions’.
Social Trinitarianism and the tripartite God
Authors: SPENCER DANIEL 
Published: September 2018

AbstractIn this article, I consider the most prominent contemporary attempts to reconcile Social Trinitarianism (ST) with monotheism, arguing that within ST, only mereological (part/whole) accounts can ultimately preserve monotheism. A corollary of this is that every other condition (or set of conditions) adduced in defense of a monotheistic ST really entails tritheism, that is, until a part/whole condition is deployed. Such models, I contend, fail necessarily insofar as they attempt to solve a puzzle that is wholly quantitative in nature with purely qualitative considerations. I conclude by remarking that the Social Trinity model propounded by William Lane Craig and J. P. Moreland succeeds where the others fail, though this model is itself by no means impervious to weighty objections.