bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compatibility effects of herb pair Phellodendri chinensis cortex and Anemarrhenae rhizoma on benign prostatic hyperplasia using targeted metabolomics
Authors: Zhao Xiaoning , Li Yiran , Huai Jiaxin , Cheng Congcong , Zhang Teng , Xie Linlin , Wang Siqi , Zhang Meng , Dai Ronghua 
Published: May 2018

AbstractPhellodendri chinensis cortex (P. C. cortex) and Anemarrhenae rhizoma (A. rhizoma) herb pair is a core component of traditional Chinese medicines used to treat inflammation and benign prostatic hyperplasia (BPH). The present study was designed to profile the arachidonic acid (AA) metabolomic characteristics in rat plasma and prostate after being treated with P. C. cortex and A. rhizoma as well as their combination. Plasma and prostate samples from sham group, BPH model group, herb pair group and two single herb groups were collected on days 7, 14, 21 and 28. Then, a systemic metabolomic analysis based on UFLC‐MS/MS was employed to quantify AA and its cyclooxygenase and lipoxygenase pathway metabolites (15‐HETE, 12‐HETE, 5‐HETE, AA, PGI2, PGF2α, 8‐HETE, PGD2, PGE2 and LTB4). The results demonstrated that BPH led a significant increase of 10 biomarkers in plasma and tissue (p < 0.05). The clusters of herb pair group and single herb groups showed a tendency to return to the initial space, and the AA and its metabolites from those groups were differently downregulated to a healthier level, with the combination of single herbs most obvious. The present study demonstrated that P. C. cortex–A. rhizoma herb pair might produce synergistic or complementary compatibility effects on suppressing inflammatory processes occurring in BPH.
Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand
Authors: Kneuttinger Andrea C. , Winter Martin , Simeth Nadja A. , Heyn Kristina , Merkl Rainer , König Burkhard , Sterner Reinhard 
Published: May 2018

AbstractThe artificial regulation of proteins by light is an emerging subdiscipline of synthetic biology. Here, we used this concept to photocontrol both catalysis and allostery within the heterodimeric enzyme complex imidazole glycerol phosphate synthase (ImGP‐S). ImGP‐S consists of the cyclase subunit HisF and the glutaminase subunit HisH, which is allosterically stimulated by substrate binding to HisF. We show that a light‐sensitive diarylethene (1,2‐dithienylethene, DTE)‐based competitive inhibitor in its ring‐open state binds with low micromolar affinity to the cyclase subunit and displaces its substrate from the active site. As a consequence, catalysis by HisF and allosteric stimulation of HisH are impaired. Following UV‐light irradiation, the DTE ligand adopts its ring‐closed state and loses affinity for HisF, restoring activity and allostery. Our approach allows for the switching of ImGP‐S activity and allostery during catalysis and appears to be generally applicable for the light regulation of other multienzyme complexes.
Identification of integrin heterodimers functioning on the surface of undifferentiated porcine primed embryonic stem cells
Authors: Kim Hwa‐Young , Baek Song , Han Na Rae , Lee Eunsong , Park Choon‐Keun , Lee Seung Tae 
Published: May 2018

AbstractIn vitro expansion of undifferentiated porcine primed embryonic stem (ES) cells is facilitated by use of non‐cellular niches that mimic three‐dimensional (3D) microenvironments enclosing an inner cell mass of porcine blastocysts. Therefore, we investigated the integrin heterodimers on the surface of undifferentiated porcine primed ES cells for the purpose of developing a non‐cellular niche to support in vitro maintenance of the self‐renewal ability of porcine primed ES cells. Immunocytochemistry and a fluorescence immunoassay were performed to assess integrin α and β subunit levels, and attachment and antibody inhibition assays were used to evaluate the function of integrin heterodimers. The integrin α3, α5, α6, α9, αV, and β1 subunits, but not the α1, α2, α4, α7, and α8 subunits, were identified on the surface of undifferentiated porcine primed ES cells. Subsequently, significant increase of their adhesion to fibronectin, tenascin C, and vitronectin were observed and functional blocking of integrin heterodimer α5β1, α9β1, or αVβ1 showed significantly inhibited adhesion to fibronectin, tenascin C, or vitronectin. No integrin α6β1 heterodimer‐mediated adhesion to laminin was detected. These results demonstrate that active α5β1, α9β1, and αVβ1 integrin heterodimers are present on the surface of undifferentiated porcine primed ES cells, together with inactive integrin α3 (presumed) and α6 subunits.
Down‐regulation of CD19 expression inhibits proliferation, adhesion, migration and invasion and promotes apoptosis and the efficacy of chemotherapeutic agents and imatinib in SUP‐B15 cells
Authors: Wu Junqing , Liang Bin , Qian Yan , Tang Liyuan , Xing Chongyun , Zhuang Qiang , Shen Zhijian , Jiang Songfu , Yu Kang , Feng Jianhua 
Published: May 2018

AbstractThe survival rate of childhood acute lymphoblastic leukemia (ALL) has increased while that of Philadelphia‐positive (Ph+) ALL remains low. CD19 is a B‐cell specific molecule related to the survival and proliferation of normal B cells. However, there is little information available on the effects of CD19 on the biological behavior of Ph+ ALL cells. In this study, we explored a lentiviral vector‐mediated short hairpin RNA (shRNA) expression vector to stably reduce CD19 expression in Ph+ ALL cell line SUP‐B15 cells and investigated the effects of CD19 downregulation on cell proliferation, apoptosis, drug sensitivity, cell adhesion, cell migration and cell invasion in vitro. CD19 mRNA and protein expression levels were inhibited significantly by CD19 shRNA. Down‐regulation of CD19 could inhibit cell proliferation, adhesion, migration and invasion, and increase cell apoptosis and the efficacy of chemotherapeutic agents and imatinib in SUP‐B15 cells. Moreover, we found that down‐regulation of CD19 expression inhibits cell proliferation and induces apoptosis in SUP‐B15 cells in a p53‐dependent manner. Taken together, our results suggest that lentiviral vector‐mediated RNA interference of CD19 gene may be a promising strategy in the treatment of Ph+ ALL.
Two Unconventional Precursors to Produce ZnCl2‐Based Activated Carbon for Water Treatment Applications
Authors: Cruz Gerardo Juan Francisco , Pirilä Minna , Matějová Lenka , Ainassaari Kaisu , Solis Jose Luis , Fajgar Radek , Šolcová Olga , Keiski Riitta Liisa 
Published: May 2018

AbstractTwo unconventional raw materials, the seeds from Spondias purpurea L. (red mombin) and Inga edulis (ice cream bean), were characterized and used as precursors to produce good‐quality zinc chloride‐activated carbons for potential use in water treatment applications. The red mombin seed was significantly more porous than the ice cream bean seed, while the activated carbons prepared from red mombin seed and ice cream bean seeds showed both a very well‐established microporous‐mesoporous structure. Equilibrium as well as kinetic adsorption experiments were conducted with methylene blue, methyl orange, and As(V). It was revealed that both seeds are unconventional, renewable, cheap, and suitable agro‐precursors for production of activated carbons with potential application in wastewater treatment.
Strong Aggregation‐Induced CPL Response Promoted by Chiral Emissive Nematic Liquid Crystals (N*‐LCs)
Authors: Li Xiaojing , Li Qian , Wang Yuxiang , Quan Yiwu , Chen Dongzhong , Cheng Yixiang 
Published: May 2018

AbstractIn this paper we designed a kind of aggregation‐induced emission (AIE) chiral fluorescence emitters (R/S‐BINOL‐CN enantiomers) in the aggregate state. Chiral emissive nematic liquid crystals (N*‐LCs) prepared by doping this kind of AIE‐activeR/S‐BINOL‐CN enantiomers into a common achiral nematic liquid crystal (N‐LC, E7) can self‐assemble as the regularly planar Grandjean texture leading to high luminescence dissymmetry factor (glum) of aggregation‐induced circularly polarized luminescence (AI‐CPL) signal up to 0.41, which can be attributed to dipolar interactions from polar cyano groups and π–π interactions between binaphthyl moiety of the dopantR/S‐BINOL‐CN and biphenyl group of the host molecules (E7).
Post‐Synthetic Mannich Chemistry on Metal‐Organic Frameworks: System‐Specific Reactivity and Functionality‐Triggered Dissolution
Authors: Amer Hamzah Harina , Gee William J. , Raithby Paul R. , Teat Simon J. , Mahon Mary F. , Burrows Andrew D. 
Published: May 2018

AbstractThe Mannich reaction of the zirconium MOF [Zr6O4(OH)4(bdc‐NH2)6] (UiO‐66‐NH2, bdc‐NH2=2‐amino‐1,4‐benzenedicarboxylate) with paraformaldehyde and pyrazole, imidazole or 2‐mercaptoimidazole led to post‐synthetic modification (PSM) through C−N bond formation. The reaction with imidazole (Him) goes to completion whereas those with pyrazole (Hpyz) and 2‐mercaptoimidazole (HimSH) give up to 41 and 36 % conversion, respectively. The BET surface areas for the Mannich products are reduced from that of UiO‐66‐NH2, but the compounds show enhanced selectivity for adsorption of CO2 over N2 at 273 K. The thiol‐containing MOFs adsorb mercury(II) ions from aqueous solution, removing up to 99 %. The Mannich reaction with pyrazole succeeds on [Zn4O(bdc‐NH2)3] (IRMOF‐3), but a similar reaction on [Zn2(bdc‐NH2)2(dabco)] (dabco=1,4‐diazabicyclo[2.2.2]octane) gave [Zn3(bdc‐NH2)1.32(bdc‐NHCH2pyz)1.68(dabco)]⋅2 C7H8 5, whereas the reaction with imidazole gave the expected PSM product. Compound 5 forms via a dissolution–recrystallisation process that is triggered by the “free” pyrazolate nitrogen atom competing with dabco for coordination to the zinc(II) centre. In contrast, the “free” nitrogen atom on the imidazolate is too far away to compete in this way. Mannich reactions on [In(OH)(bdc‐NH2)] (MIL‐68(In)‐NH2) stop after the first step, and the product was identified as [In(OH)(bdc‐NH2)0.41(bdc‐NHCH2OCH3)0.30(bdc‐N=CH2)0.29], with addition of the heterocycle prevented by steric interactions.
Survey on the theoretical research and engineering applications of multivariate statistics process monitoring algorithms: 2008–2017
Authors: Wang Youqing , Si Yabin , Huang Biao , Lou Zhijiang 
Published: May 2018

AbstractMultivariate statistical process monitoring (MSPM) methods are significant for improving production efficiency and enhancing safety. However, to the authors’ best knowledge, there is no survey paper providing statistics of published papers over the past decade. In this paper, several issues related to MSPM methods are reviewed and studied. First, the annual publication numbers of journal articles concerning MSPM are provided to show the active development of this important research field and to point out several promising directions in the future. Second, the annual numbers of patents are also shown to demonstrate the practicality of different MSPM methods. Particularly, this paper also lists and analyzes the number of MSPM‐related publications in China. The statistics indicate that Chinese researchers and engineers may have different viewpoints from those of other countries, which results in different development trends of MSPM in China.
An approach to custom privacy policy violation detection problems using big social provenance data
Authors: Baeth Mohamed Jehad , Aktas Mehmet S. 
Published: May 2018

SummarySocial media software changes its system‐wide privacy policies over time. Changes in such system‐wide policies affect the privacy policies of the individual users. In turn, social media users lack the ability to configure and enforce customized privacy policies according to the precise privacy measure that they demand. To this end, we argue that there is an emerging need for third‐party solutions that are independent of existing social media software and that can detect custom privacy policy violations. In order to address this need, we propose an approach to detecting custom privacy violations for social media users. We also introduce a generic software architecture that can be integrated with existing social media software to enable users to keep track of their data. The proposed solution utilizes social provenance data, which is defined as the metadata that describe the lifecycle of the data. To facilitate testing of the software architecture, we developed a prototype implementation and generated a large‐scale synthetic provenance dataset. We discuss the details of the prototype implementation and the synthetic dataset. We evaluate the performance of the prototype under an increasing workload. We show the usability of the proposed architecture, as the initial performance testing results are promising.
Oxidatively‐Stable Linear Poly(propylenimine)‐Containing Adsorbents for CO2 Capture from Ultradilute Streams
Authors: Pang Simon H. , Lively Ryan P. , Jones Christopher W. 
Published: May 2018

AbstractAminopolymer‐based solid sorbents have been widely investigated for the capture of CO2 from dilute streams such as flue gas or ambient air. However, the oxidative stability of the widely studied aminopolymer, poly(ethylenimine) (PEI), is limited, causing it to lose its CO2 capture capacity after exposure to oxygen at elevated temperatures. Here, we demonstrate the use of linear poly(propylenimine) (PPI), synthesized through a simple cationic ring‐opening polymerization, as a more oxidatively stable alternative to PEI with high CO2 capacity and amine efficiency. The performance of linear PPI/SBA‐15 composites was investigated over a range of CO2 capture conditions (CO2 partial pressure, adsorption temperature) to examine the tradeoff between adsorption capacity and sorption‐site accessibility, which was expected to be more limited in linear polymers relative to the prototypical hyperbranched PEI. Linear PPI/SBA‐15 composites were more efficient at CO2 capture and retained 65–83 % of their CO2 capacity after exposure to a harsh oxidative treatment, compared to 20–40 % retention for linear PEI. Additionally, we demonstrated long‐term stability of linear PPI sorbents over 50 adsorption/desorption cycles with no loss in performance. Combined with other strategies for improving the oxidative stability and adsorption kinetics, linear PPI may play a role as a component of stable solid adsorbents in commercial applications for CO2 capture.
Adjusting the Introduction of Cations for Highly Efficient and Stable Perovskite Solar Cells Based on (FAPbI3)0.9(FAPbBr3)0.1
Authors: Liu Guozhen , Zheng Haiying , Zhu Liangzheng , Alsaedi Ahmed , Hayat Tasawar , Pan Xu , Mo Li'e , Dai Songyuan 
Published: May 2018

AbstractAlthough the power conversion efficiency (PCE) of perovskite solar cells (PSCs) has increased to 22.7 %, the instability when exposed to moisture and heat has hindered their further practical development. In this study, to gain highly efficient and stable perovskite components, methylammonium (MA), Cs, and Rb cations are introduced into a (FAPbI3)0.9(FAPbBr3)0.1 (FA=formamidine) film, which is rarely used because of its poor photovoltaic performance. The effects of different contents of MA, Cs, or Rb cations on the performance of (FAPbI3)0.9(FAPbBr3)0.1 films and devices are systematically studied. The results show that the devices with Cs cations exhibit markedly improved photovoltaic performance and stability, attributed to the clearly enhanced quality of films and their intrinsic stability. The (FAPbI3)0.9(FAPbBr3)0.1 devices with 10 % Cs show a PCE as high as 19.94 %. More importantly, the unsealed devices retain about 80 % and 90 % of the initial PCE at 85 °C after 260 h and under 45±5 % relative humidity (RH) after 1440 h, respectively, which are better than that with 15 % MA and 5 % Rb under the same conditions. This indicates that a highly efficient and stable perovskite component has been achieved, and PSCs based on this component are expected to promote their further development.
Highly Active Catalytic Ruthenium/TiO2 Nanomaterials for Continuous Production of γ‐Valerolactone
Authors: Xu Chunping , Ouyang Weiyi , Muñoz‐Batista Mario J. , Fernández‐García Marcos , Luque Rafael 
Published: May 2018

AbstractGreen energy production from renewable sources is an attractive, but challenging topic to face the likely energy crisis scenario in the future. In the current work, a series of versatile Ru/TiO2 catalysts were simply synthesized and employed in continuous‐flow catalytic transfer hydrogenation of industrially derived methyl levulinate biowaste (from Avantium Chemicals B.V.) to form γ‐valerolactone. Different analytical techniques were applied in the characterization of the as‐synthesized catalysts, including XRD, SEM, energy‐dispersion X‐ray spectroscopy, TEM, and X‐ray photoelectron spectroscopy. The effects of various reaction conditions (e.g., temperature, concentration, and flow rate) were investigated. Results suggested that optimum dispersion and distribution of Ru on the TiO2 surface could efficiently promote the production of γ‐valerolactone; the 5 % Ru/TiO2 catalyst provided excellent catalytic performance and stability compared with commercial Ru catalysts.
Water Splitting–Biosynthetic Hybrid System for CO2 Conversion using Nickel Nanoparticles Embedded in N‐Doped Carbon Nanotubes
Authors: Li Zhongjian , Li Gang , Chen Xinlu , Xia Zheng , Yao Jiani , Yang Bin , Lei Lecheng , Hou Yang 
Published: May 2018

AbstractCO2 reduction has drawn increasing attention owing to the concern of global warming. Water splitting–biosynthetic hybrid systems are novel and efficient approaches for CO2 conversion. Intimate coupling of electrocatalysts and biosynthesis requires the catalysts possess both high catalytic performance and excellent biocompatibility, which is a bottleneck of developing such catalysts. Here, a complex of Ni nanoparticles embedded in N‐doped carbon nanotubes (Ni@N‐C) is synthesized as a hydrogen evolution reaction electrocatalyst and is coupled with a hydrogen oxidizing autotroph, Cupriavidus necator H16, to convert CO2 to poly‐β‐hydroxybutyrate. In Ni@N‐C, the Ni nanoparticles are encapsulated in N‐C nanotubes, which prevents bacteria from direct contact with Ni and inhibits Ni2+ leaching. As a result, Ni@N‐C exhibits excellent biocompatibility and stability. This work demonstrates that electrocatalysts and biosynthesis can be intimately coupled through rational catalyst design.
Oxygen Evolution Catalysts Based on Ir–Ti Mixed Oxides with Templated Mesopore Structure: Impact of Ir on Activity and Conductivity
Authors: Bernsmeier Denis , Bernicke Michael , Schmack Roman , Sachse René , Paul Benjamin , Bergmann Arno , Strasser Peter , Ortel Erik , Kraehnert Ralph 
Published: May 2018

AbstractThe efficient generation of hydrogen via water electrolysis requires highly active oxygen evolution catalysts. Among the active metals, iridium oxide provides the best compromise in terms of activity and stability. The limited availability and usage in other applications demands an efficient utilization of this precious metal. Forming mixed oxides with titania promises improved Ir utilization, but often at the cost of a low catalyst surface area. Moreover, the role of Ir in establishing a sufficiently conductive mixed oxide has not been elucidated so far. We report a new approach for the synthesis of Ir/TiOx mixed‐oxide catalysts with defined template‐controlled mesoporous structure, low crystallinity, and superior oxygen evolution reaction (OER) activity. The highly accessible pore system provides excellent Ir dispersion and avoids transport limitations. A controlled variation of the oxides Ir content reveals the importance of the catalysts electrical conductivity: at least 0.1 S m−1 are required to avoid limitations owing to slow electron transport. For sufficiently conductive oxides a clear linear correlation between Ir surface sites and OER currents can be established, where all accessible Ir sites equally contribute to the reaction. The optimized catalysts outperform Ir/TiOx materials reported in literature by about a factor of at least four.
High‐Performance Solid Oxide Fuel Cell with an Electrochemically Surface‐Tailored Oxygen Electrode
Authors: Park Beom‐Kyeong , Lee Seung‐Bok , Lim Tak‐Hyoung , Song Rak‐Hyun , Lee Jong‐Won 
Published: May 2018

AbstractState‐of‐the‐art cathodes for solid oxide fuel cells (SOFCs), such as (La,Sr)MnO3–(Y2O3)0.08(ZrO2)0.92 (LSM–YSZ), suffer from sluggish oxygen reduction reaction (ORR) kinetics at reduced temperatures, leading to a significant decline in their performance. Herein, we report a tailored SOFC cathode with high ORR activity at intermediate temperatures using a simple but effective approach based on “electrochemical” surface modification. The proposed process involves chemically assisted electrodeposition (CAED) of a metal hydroxide (LaCo(OH)x) on LSM–YSZ surfaces followed by in situ thermal conversion of LaCo(OH)x to perovskite‐type LaCoO3 (LCO) nanoparticles during the SOFC startup. This method facilitates easy loading of the LCO nanoparticles with a precisely controlled morphology without the need for repeated deposition/annealing processes. An anode‐supported SOFC with the LCO‐tailored LSM–YSZ electrode exhibits a remarkably increased power density, approximately 180 % at 700 °C, compared with an SOFC with the pristine electrode as well as excellent long‐term stability, which are attributed to the beneficial role of the CAED‐derived LCO nanoparticles in enlarging the active areas for ORR and promoting oxygen adsorption/diffusion. This work demonstrates that controlled surface tailoring of the cathode by CAED could be an effective approach for improving the performance of SOFCs at reduced temperatures.
Tuning the Gas Selectivity of Tröger's Base Polyimide Membranes by Using Carboxylic Acid and Tertiary Base Interactions
Authors: Wang Zhenggong , Isfahani Ali Pournaghshband , Wakimoto Kazuki , Shrestha Binod Babu , Yamaguchi Daisuke , Ghalei Behnam , Sivaniah Easan 
Published: May 2018

AbstractPolyimide‐based materials provide attractive chemistries for the development of gas‐separation membranes. Modification of inter‐ and intra‐chain interactions is a route to improve the separation performance. In this work, copolyimides with Tröger's base (TB) monomers are designed and synthesized. In particular, a series of copolyimides is synthesized with different contents of carboxylic acid groups (0–50 wt %) to alter the inter‐ and intra‐chain interactions and enhance the basicity of the TB‐polyimides. A detailed thermal and structural analysis is provided for the new copolyimides. Gas permeation data reveal a tunable trend in separation performance with increasing carboxylic acid group content. Importantly, this is one of the few examples of copolyimide membranes materials that show enhanced plasticization resistance to high‐pressure gas feeds through physical cross‐linking.