bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the top 100 most influential papers in benign prostatic hyperplasia
Authors: Shah Rohan , Kashkoush Jasmine , Kashkoush Ahmed , Patel Trushar 
Published: June 2019

Introduction: The fund of knowledge on benign prostatic hypertrophy (BPH) has been growing since the 1970s. Citation analysis is a tool by which we can quantify influence of specific articles and assess the growth of a certain topic. This paper seeks to identify trends, as well as draw attention to the most influential papers, authors, and journals. Many analogous studies have been done, but none have been done in the field of BPH.
Methods: We used Thomson Reuters Web of Science to collect articles pertaining to BPH in a two-step fashion. We identified 117 keywords relevant to BPH and using these 117 words, we were able to identify 7302 total articles. These articles were organized by number of citations. Of the top 200 articles, 100 articles were excluded based on title and abstract analysis. One hundred articles were included for final analysis, as this is the standard of citation analysis.
Results: Overall, total citations were slightly correlated with journal impact factor. Author analysis revealed no significant difference between authorship and average citations. Topic analysis showed the most cited topic was surgical management with 657.35 citations per year. Study design analysis showed the predominant study design was the randomized control trial.
Conclusions: By using the two-step methodology, we were able to create a list of the top 100 most influential articles in the field of BPH. In doing so, we illustrated the growth of the field over time and paid tribute to the myriad of papers, authors, and journals that have shaped the field to this day.
Diseño y construcción de una casa bioclimática en clima cálido seco, en La Paz, Baja California Sur, México
Authors: Reséndiz Pacheco Oscar , Morillón Gálvez David , Romero Ramona Alicia , Galindo De La Cruz Madelein , Poujol Federico , Chávez Martínez Elizabeth 
Published: June 2019

A través de un proyecto multiinstitucional de CONAVI se realizó un estudio térmico y energético para el análisis y obtención de un prototipo de vivienda en clima cálido seco en la ciudad de La Paz, B.C.S., en el que se abordan estrategias ahorradoras de energía y confort térmico, así como de diseño para poder ofrecer una alternativa a la problemática actual en la vivienda económica.
A través d'un projecte multi institucional de CONAVI es va realitzar un estudi tèrmic i energètic per a l'anàlisi i obtenció d'un prototip d'habitatge en clima càlid sec a la ciutat de la Pau, BCS, en el qual s'aborden estratègies estalviadores d'energia i confort tèrmic , així com de disseny per poder oferir una alternativa a la problemàtica actual a l'habitatge econòmica.
Through a multi-agency Project CONAVI thermal and energy study for analysis and obtaining a house prototype in warm dry weather in the city of La Paz, BCS, where saving energy strategies and comfort are addressed performed thermal and design to offer an alternative to the current problems in afford housing. They showed considerable benefits in terms of energy performance and thermal comfort due to the proposed changes in the housing design.
Evaluating the Adoption of Laboratory Practice Guidelines
Authors: Goldsmith Jeffrey D. , Fitzgibbons Patrick L. , Fatheree Lisa A. , Astles J. Rex , Nowak Jan A. , Souers Rhona J. , Volmar Keith E. , Nakhleh Raouf E. 
Published: June 2019

Context.—
To date, the College of American Pathologists (CAP) has developed 17 laboratory practice guidelines (LPGs) including updates. In 2013, the CAP was awarded a 5-year cooperative agreement grant from the United States Centers for Disease Control and Prevention to increase the effectiveness of LPGs.

Objective.—
To assess the awareness and adoption of 2 CAP LPGs: immunohistochemical (IHC) assay validation and initial workup of acute leukemia.

Design.—
Baseline surveys for each LPG were conducted in 2010 and 2015, respectively. To measure the adoption of guideline recommendations and inform future updates, a follow-up study consisting of surveys, telephone interviews, and focus group sessions was conducted in laboratories that indicated they perform IHC testing. A follow-up study for the acute leukemia LPG is planned.

Results.—
For the IHC Validation LPG, a total of 1624 survey responses, 40 telephone interviews, and discussions with 5 focus group participants were analyzed. The response rate for the aforementioned 3 modalities was 46%, 13%, and 3%, respectively. All modalities indicated most respondents were aware of the LPG and had adopted most or all of its recommendations. Respondents expressed needs for continued communication, increased specificity, and more prescriptive recommendations when the guideline is updated.

Conclusions.—
While data-driven development of evidence-based LPGs requires significant resources, active data collection to identify gaps and assess adoption contributes to improved laboratory testing practices in support of patient care. The CAP identified sustainable modalities to track metrics and developed multiple tools that should improve guideline development, adoption, and implementation. Of these modalities, written or electronic surveys were the most logistically feasible and had the highest response rate.
A proteção do conhecimento tradicional associado à biodiversidade diante de um novo marco legal
Authors: Shiraishi Neto Joaquim , Ribeiro Thayana Bosi Oliveira , Rabêlo Laíza Braga 
Published: June 2019

Observa-se que a Convenção sobre a Diversidade Biológica de 1992, e dela decorrente, o Protocolo de Nagoya e a Lei nº 13.123 de 20 de maio de 2015 recorreram aos “novos paradigmas” para justificar velhas práticas ao vincular a proteção da sociobiodiversidade às necessidades do mercado. Assim, este artigo, resultado parcial de um Projeto de Pesquisa, objetiva analisar o conteúdo dos tratados internacionais e da legislação pátria deles resultante, uma vez que a regulamentação jurídica do acesso ao conhecimento tradicional associado à biodiversidade pode, ao contrário do que pretende efetivamente promover, ameaçar a existência da própria sociobiodiversidade brasileira.
Conductive-probe atomic force microscopy and Kelvin-probe force microscopy characterization of OH-terminated diamond (111) surfaces with step-terrace structures
Authors: Nagai Masatsugu , Yoshida Ryo , Yamada Tatsuki , Tabakoya Taira , Nebel Christoph E. , Yamasaki Satoshi , Makino Toshiharu , Matsumoto Tsubasa , Inokuma Takao , Tokuda Norio 
Published: June 2019

Abstract
We characterized OH-terminated diamond (111) surfaces which show step-terrace (ST) and bunching-step (BS) regions from contact potential difference (CPD) and current to investigate the relationships between surface topography and generation of interface states on the surfaces. The OH-termination was performed using water vapor annealing. The CPD and current measurements were conducted by conductive-probe AFM and Kelvin-probe force microscopy. The CPD and current were highly correlated with the surface topography. The I–V characteristics shows typical ideality factors (n) of about 1.5 and 2.0 in the ST region and the BS region, respectively. As the n were higher than that of an ideal Schottky contact (n = 1.0), we concluded that a metal insulator semiconductor diode structure, whose n increases as its interface state density increases, was formed. Considering that step density in the BS region was much higher than that in the ST region, the steps seemed to have generated the interface states.
Bacterial and archaeal spatial distribution and its environmental drivers in an extremely haloalkaline soil at the landscape scale
Authors: Martínez-Olivas Martha Adriana , Jiménez-Bueno Norma G. , Hernández-García Juan Alfredo , Fusaro Carmine , Luna-Guido Marco , Navarro-Noya Yendi E. , Dendooven Luc 
Published: June 2019

Background
A great number of studies have shown that the distribution of microorganisms in the soil is not random, but that their abundance changes along environmental gradients (spatial patterns). The present study examined the spatial variability of the physicochemical characteristics of an extreme alkaline saline soil and how they controlled the archaeal and bacterial communities so as to determine the main spatial community drivers.

Methods
The archaeal and bacterial community structure, and soil characteristics were determined at 13 points along a 211 m transect in the former lake Texcoco. Geostatistical techniques were used to describe spatial patterns of the microbial community and soil characteristics and determine soil properties that defined the prokaryotic community structure.

Results
A high variability in electrolytic conductivity (EC) and water content (WC) was found. Euryarchaeota dominated Archaea, except when the EC was low. Proteobacteria, Bacteroidetes and Actinobacteria were the dominant bacterial phyla independent of large variations in certain soil characteristics. Multivariate analysis showed that soil WC affected the archaeal community structure and a geostatistical analysis found that variation in the relative abundance of Euryarchaeota was controlled by EC. The bacterial alpha diversity was less controlled by soil characteristics at the scale of this study than the archaeal alpha diversity.

Discussion
Results indicated that WC and EC played a major role in driving the microbial communities distribution and scale and sampling strategies were important to define spatial patterns.
Rosmarinic acid treatment during porcine oocyte maturation attenuates oxidative stress and improves subsequent embryo developmentin vitro
Authors: Zhang Yan , Guo Jing , Nie Xiao Wei , Li Zi Yue , Wang Yu Meng , Liang Shuang , Li Suo 
Published: June 2019

BackgroundIn vitromaturation (IVM) of oocytes has been widely used in the field of assisted reproductive technology. However, oocytes can be injured by oxidative stress during the process of IVM.MethodsThe present study was designed to evaluate the influences of rosmarinic acid (RA) on the IVM of porcine oocytes and the subsequent development of early-stage embryos as well as its underlying mechanisms. Various concentrations of RA (5 µM, 10 µM, and 25 µM) were treated with porcine oocyte maturation medium during the period of IVM.Results and DiscussionThe results showed that 5 µM RA treatment during the period of porcine oocyte IVM improves blastocyst quality and hatching ability after parthenogenetic activation. Furthermore, the presence of RA during the period of IVM dramatically improved the total number of cells after somatic cell nuclear transfer compared to the number of cells in the control group. Notably, RA treatment during the period of porcine oocyte IVM decreased intracellular reactive oxygen species generation not only in oocytes but also in cumulus cells. Further analysis showed that the intracellular free thiols levels in the oocytes were enhanced by treatment with RA during the period of porcine oocyte IVM compared to the free thiols levels in the control groups. These results indicate that RA improves the developmental competence of porcine oocytes during the IVM period by attenuating oxidative stress.
MAIT cells as attractive vaccine targets
Authors: Downey A. Michael , Kapłonek Paulina , Seeberger Peter H. 
Published: June 2019

Mucosal‐associated invariant T (MAIT) cells are a subset of T cells that perform innate‐like immunity functions upon recognition of small molecule vitamin B metabolites presented by the MHC, class I‐related protein‐1 (MR1). MAIT cells are profuse in humans, but especially abundant in blood, liver, lungs, and mucosal layers. The mucosa is a common site of carcinogenesis and MAIT cells have been found in both primary and metastatic tumors. MAIT cells target a host of microbes including Mycobacterium tuberculosis, Staphylococcus aureus, Salmonella enterica, Legionella longbeachae, Escherichia coli, and Candida albicans, and are highly activated in viral infections. Cytokines produced by MAIT cells are both anticancerous and antibacterial, but also have proinflammatory and possibly tumorigenic properties. In addition, it is believed that MAIT cells play a protective role in viral infections in an MR1‐independent fashion. Based on our summary of recent advances concerning both MR1‐mediated and MR1‐independent MAIT cell immune responses, we weigh the strengths and weaknesses of these cells for vaccine development.
Characterizing mechanical and medical imaging properties of polyvinyl chloride‐based tissue‐mimicking materials
Authors: He Yaoyao , Qin Shengxue , Dyer Brandon A. , Zhang Hongbin , Zhao Lifen , Chen Tiao , Zheng Fenglian , Sun Yong , Shi Liting , Rong Yi , Qiu Jianfeng 
Published: June 2019

AbstractPolyvinyl chloride (PVC) is a commonly used tissue‐mimicking material (TMM) for phantom construction using 3D printing technology. PVC‐based TMMs consist of a mixture of PVC powder and dioctyl terephthalate as a softener. In order to allow the clinical use of a PVC‐based phantom use across CT and magnetic resonance imaging (MRI) imaging platforms, we evaluated the mechanical and physical imaging characteristics of ten PVC samples. The samples were made with different PVC‐softener ratios to optimize phantom bioequivalence with physiologic human tissue. Phantom imaging characteristics, including computed tomography (CT) number, MRI relaxation time, and mechanical properties (e.g., Poisson’s ratio and elastic modulus) were quantified. CT number varied over a range of approximately −10 to 110 HU. The relaxation times of the T1‐weighted and T2‐weighted images were 206.81 ± 17.50 and 20.22 ± 5.74 ms, respectively. Tensile testing was performed to evaluate mechanical properties on the three PVC samples that were closest to human tissue. The elastic moduli for these samples ranged 7.000–12.376 MPa, and Poisson’s ratios were 0.604–0.644. After physical and imaging characterization of the various PVC‐based phantoms, we successfully produced a bioequivalent phantom compatible with multimodal imaging platforms for machine calibration and image optimization/benchmarking. By combining PVC with 3D printing technologies, it is possible to construct imaging phantoms simulating human anatomies with tissue equivalency.
Metal Ion‐Terpyridine‐Functionalized L‐Tyrosinamide Aptamers: Nucleoapzymes for Oxygen Insertion into CH Bonds and the Transformation of L‐Tyrosinamide into Amidodopachrome
Authors: Luo Guo‐Feng , Biniuri Yonatan , Vázquez‐González Margarita , Wulf Verena , Fadeev Michael , Lavi Ronit , Willner Itamar 
Published: June 2019

AbstractA series of metal ion‐terpyridine‐modified L‐tyrosinamide aptamers (Mn+ = Cu2+ or Fe3+) act as enzyme‐mimicking catalysts (nucleoapzymes) for oxygen‐insertion into CH bonds and the transformation of L‐tyrosinamide into amidodopachrome. The reaction proceeds in the presence of H2O2 and coadded L‐ascorbic acid. In one series of experiments, the catalyzed oxidation of L‐tyrosinamide to amidodopachrome by a set of nucleoapzymes consisting of Fe3+‐ or Cu2+‐terpyridine complexes tethered directly or through a 4 × thymidine (4 × T) bridge, to the 5′‐ or 3′‐end of the 49‐mer L‐tyrosinamide aptamer or to a shorter 23‐mer L‐tyrosinamide aptamer is examined. All nucleoapzymes reveal catalytic Michaelis–Menten enzyme‐like activities and the separated Fe3+‐ or Cu2+‐terpyridine and L‐tyrosinamide aptamer units show only minute catalytic properties. The catalytic activities of the nucleoapzymes are attributed to the concentration of the L‐tyrosinamide substrate by the aptamer units in proximity to the catalytic sites (Kd = (14 ± 0.1) × 10−6 m for all 49‐mer catalysts and Kd = (2.5 ± 0.1) × 10−6 m and Kd = (0.8 ± 0.04) × 10−6 m for the 23‐mer catalysts). Electron spin resonance experiments reveal that •OH radicals and ascorbate radicals participate in the transformation of tyrosine derivatives to catechol products. An autocatalytic feedback mechanism for the amplified generation of the two radicals is suggested.
Inherent Photodegradability of Polymethacrylate Hydrogels: Straightforward Access to Biocompatible Soft Microstructures
Authors: Li Lei , Scheiger Johannes M. , Tronser Tina , Long Connor , Demir Konstantin , Wilson Christina L. , Kuzina Mariia A. , Levkin Pavel A. 
Published: June 2019

AbstractHydrogels are important functional materials useful for 3D cell culture, tissue engineering, 3D printing, drug delivery, sensors, or soft robotics. The ability to shape hydrogels into defined 3D structures, patterns, or particles is crucial for biomedical applications. Here, the rapid photodegradability of commonly used polymethacrylate hydrogels is demonstrated without the need to incorporate additional photolabile functionalities. Hydrogel degradation depths are quantified with respect to the irradiation time, light intensity, and chemical composition. It can be shown that these parameters can be utilized to control the photodegradation behavior of polymethacrylate hydrogels. The photodegradation kinetics, the change in mechanical properties of polymethacrylate hydrogels upon UV irradiation, as well as the photodegradation products are investigated. This approach is then exploited for microstructuring and patterning of hydrogels including hydrogel gradients as well as for the formation of hydrogel particles and hydrogel arrays of well‐defined shapes. Cell repellent but biocompatible hydrogel microwells are fabricated using this method and used to form arrays of cell spheroids. As this method is based on readily available and commonly used methacrylates and can be conducted using cheap UV light sources, it has vast potential to be applied by laboratories with various backgrounds and for diverse applications.
Plasmonic Self‐Propelled Nanomotors for Explosives Detection via Solution‐Based Surface Enhanced Raman Scattering
Authors: Novotný Filip , Plutnar Jan , Pumera Martin 
Published: June 2019

AbstractNanomotors represent a class of artificial machines that span the chasm between molecular motors and bigger micromotors. Their importance lies in the fact that to effectively navigate and perform tasks in a biological environment without alerting the action of the immune system, the maximal size of the object has to be well below 200 nm. Fully nanosized gold/silver core/shell plasmonic nanomotors using the seeded growth wet chemical approach, which allows high scalability of synthesis of the nanomotors compared to planar substrate‐based methods, is presented. Using the nanoparticle tracking analysis, the catalysis driven enhanced diffusion of the plasmonic nanomotors in the presence of low concentrations of fuel is presented and shown that the prepared nanomotors are good candidates for a solution‐based surface‐enhanced Raman spectroscopy detection of picric acid, a typical explosive. In addition to the mentioned effects, ligand‐exchange is performed on the nanomotors to replace the surfactant with its thiolated analog, a combination which is already proven in literature to be stealthy to the immune response of the living organism.
3D Structural Strengthening Urchin‐Like Cu(OH)2‐Based Symmetric Supercapacitors with Adjustable Capacitance
Authors: Chang Peng , Mei Hui , Zhao Yu , Huang Weizhao , Zhou Shixiang , Cheng Laifei 
Published: June 2019

AbstractDeveloping advanced three‐dimensional (3D) structural supercapacitors with both high capacity and good mechanical strength remains challenging. Herein, a novel road is reported for fabricating 3D structural strengthening supercapacitors with adjustable capacitance based on urchin‐like Cu(OH)2 lattice electrodes by bridging 3D printing technology with a facile electroless plating and electro‐oxidation method. As revealed by the results, the 3D‐printed octet‐truss lattice electrode features a high volumetric capacitance of 8.46 F cm−3 at 5 mA cm−3 and superior retention capacity of 68% at 1 A cm−3. The assembled symmetric supercapacitor with a 70.2% capacitance retention after 5000 cycles possesses a 12.8 Wh kg−1 energy density at a power density of 2110.2 W kg−1. Additionally, the resulting 3D structural strengthening electrodes can achieve both high compressive strength and toughness of 30 MPa and 264.7 kJ m−3, respectively, demonstrating high mechanical strength and excellent antideformation capacity. With the proposed strategy, the electrochemical and mechanical properties of these novel 3D structural strengthened supercapacitors can be easily tuned by a simple spatial framework design, fulfilling the increasing demand of highly customized power sources in the space‐constrained microelectronics and astronautic electronics industries.
Stretchable Transparent Conductors: from Micro/Macromechanics to Applications
Authors: Chen Zhi Hong , Fang Rui , Li Wei , Guan Jianguo 
Published: June 2019

AbstractStretchable transparent conductors (STCs), generally consisting of conducting networks and stretchable transparent elastomers, can maintain stable conductivity and transparency even at large tensile strain, beyond the reach of rigid/flexible transparent conductors. They are essential components in stretchable/wearable electronics for using on irregular 3D conformable surfaces and have attracted tremendous attention in recent years. This review aims to provide systematical correlation of the conducting element–substrate interaction with the structural stability of conducting networks, as well as the properties and device applications of STCs. It starts with the micromechanics for stretching of conducting elements on substrates, including the mechanical mismatch, distribution/level of interfacial shear stress, and the deformation behavior of conducting elements on substrates. The macromechanics for stretching of conducting networks on substrates are then further illustrated from a more statistical point of view, namely sliding/preferred orientation of percolation networks, unfolding of buckled structures, and unit cell distortion/distributed rupture of nanomeshes. The structure‐dependent properties as well as the state‐of‐the‐art applications of STCs are summarized before ending with the conclusions and outlooks for STCs.
Laser Systems and Networks with Organic Nanowires and Nanofibers
Authors: Matino Francesca , Persano Luana , Camposeo Andrea , Pisignano Dario 
Published: June 2019

AbstractThe potentialities of miniaturized laser sources are still far from being fully developed. Unprecedented opportunities are generated in this field by organic nanowires and nanofibers, which can be used as building blocks of micro‐ and nanolasers in which they combine optical gain, waveguiding, and very high versatility to create nanophotonic networks. The progress in laser devices and network architectures based on optically pumped organic light‐emitting nanowires and nanofibers is here presented, with emphasis on developed active materials, fabrication technologies, lasing mechanisms, and cavity geometries, and on achieved device performance in terms of spectral tunability, excitation threshold, and resonator quality factors. Recent examples of optical coupling of different miniaturized lasers, of their application in optical sensing, and of network lasers are presented. Future directions for research are also outlined, which include the exploration of new classes of active organic or hybrid materials within nanowires, the more in‐depth characterization of the fundamental properties of these lasers, and the use of topologically defined organic nanophotonics in network science, computing, and diagnostics.