Utilização da estimulação magnética transcraniana como método diagnóstico em crianças: uma revisão sistemática
Authors: Brandão Renata De Assis Fonseca Santos , Fregni Felipe , Sena Eduardo Pondé de 
Published: May 2018

<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:HyphenationZone>21</w:HyphenationZone> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>PT-BR</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val="--" /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--> <p class="MsoNormal" style="margin-top: 0cm; margin-right: 22.7pt; margin-bottom: .0001pt; margin-left: 22.7pt; text-align: justify; mso-layout-grid-align: none; text-autospace: none;"><strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">Objetivo</span></strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;">: Esta revisão sistemática tem como objetivo revisar o uso da estimulação magnética transcraniana (EMT) como método diagnóstico em crianças. <strong>Metodologia</strong>: Foi realizada por meio da busca nos bancos de dados do National Center for Biotechnology Information via Pubmed e da The Cochrane Library,, durante o período de 2002 a junho de 2012. Foram utilizadas como palavras-chave: transcranial magnetic stimulation (TMS) AND child. Os critérios de inclusão foram: ensaios clínicos realizados com estimulação magnética transcraniana com pulso simples e/ou pareado, idade amostral de 0 a 18 anos, publicação em língua inglesa, portuguesa ou espanhola. <strong>Resultados</strong>: De acordo com os critérios, cinco artigos foram incluídos. Entre eles, dois utilizaram a EMT para avaliação de eficiência medicamentosa em crianças com transtorno do déficit de atenção/hiperatividade; um para avaliar a eficiência da toxina botulínica em crianças com paralisia cerebral; um utilizou a EMT em bebês internados na UTI neonatal; e um descreveu nova maneira de avaliação através da utilização da EMT e ressonância magnética funcional. <strong>Conclusões</strong>: Os estudos mostraram que a EMT pode ser uma ferramenta útil na avaliação da excitabilidade cortiço-espinhal em crianças. Os parâmetros utilizados nos estudos foram diferentes, o que indica a necessidade de novas pesquisas, seguindo parâmetros semelhantes na população infantil.</span></p> <p class="MsoNormal" style="margin-top: 0cm; margin-right: 22.7pt; margin-bottom: .0001pt; margin-left: 22.7pt; text-align: justify; mso-layout-grid-align: none; text-autospace: none;"><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri;"> </span></p> <p class="MsoNormal" style="margin-top: 0cm; margin-right: 22.7pt; margin-bottom: .0001pt; margin-left: 22.7pt; text-align: justify; mso-layout-grid-align: none; text-autospace: none;"><strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri; mso-ansi-language: EN-US;" lang="EN-US">Abstract</span></strong></p> <p class="MsoNormal" style="margin-top: 0cm; margin-right: 22.7pt; margin-bottom: .0001pt; margin-left: 22.7pt; text-align: justify; mso-layout-grid-align: none; text-autospace: none;"><strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri; mso-ansi-language: EN-US;" lang="EN-US">Aims</span></strong><span style="font-size: 8.0pt; mso-bidi-font-family: Calibri; mso-ansi-language: EN-US;" lang="EN-US">:This systematic review aims to review the use of transcranial magnetic stimulation (TMS) as a diagnostic method in children. <strong>Methodology</strong>: We searched the following databases: National Center for Biotechnology Information via Pubmed and the Cochrane Library, during the period from Jan 2002 to June 2012; using the keywords transcranial magnetic stimulation (TMS) AND child. Inclusion criteria were clinical studies with transcranial magnetic stimulation using single pulse and / or paired pulse; age between 0 and 18 years, published in English, Portuguese or Spanish. <strong>Results</strong>: Five articles met our inclusion criteria and were included. Among them, two used TMS to assess drug effectiveness in children with attention deficit disorder / hyperactivity, one to evaluate the effectiveness of botulinum toxin in children with cerebral palsy, one used TMS in infants hospitalized in neonatal intensive care unit, and one described a new way of evaluation by using TMS and functional magnetic resonance imaging. <strong>Conclusion</strong>: These studies have shown that TMS can be a useful tool in assessing corticospinal excitability in children. The parameters used in these studies were different, which indicates the need for further research as to validate TMS as a diagnostic marker of corticospinal excitability. </span></p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="9" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 3" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 4" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 5" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 6" /> 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