bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Tomographic Classification of Myopic Choroidal Neovascularization
Authors: Pascual-Camps Isabel , Andreu-Fenoll María , Ruiz-Moreno Jose María , Dolz-Marco Rosa , Gallego-Pinazo Roberto 
Published: November 2018

BACKGROUND AND OBJECTIVES:
To investigate the prognostic value of the development of a hyperreflective envelopment of the neovascular tissue in myopic choroidal neovascularization (mCNV) after the first intravitreal ranibizumab injection and to establish a tomographic classification of mCNV depending on this healing process.

PATIENTS AND METHODS:
Twenty-five eyes of 25 patients with mCNV were retrospectively studied. Patients were classified into type A (presence of a hyperreflective coating of the neovascular tissue 1 month after first intravitreal ranibizumab) and type B (absence of or partial coating). Visual acuity (VA) and number of injections were recorded. Differences between both types were assessed at 6 and 12 months of follow-up.

RESULTS:
Fifteen patients (60%) were classified as type A and 10 as type B (40%). Type A showed better VA than type B. VA improvement was only significant for type A. No differences in the number of injections were observed; however, a trend to a larger amount in type B was observed.

CONCLUSIONS:
The proposed classification may have prognostic value, with type A mCNV showing better visual outcomes. Further studies are needed to confirm these findings.

[
Ophthalmic Surg Lasers Imaging Retina
. 2018;49:775–779.]
Multifocal Electroretinography in Diabetic Retinopathy With and Without Macular Edema
Authors: Goel Neha , Prakash Abhinav , Gupta A. K. 
Published: November 2018

BACKGROUND AND OBJECTIVES:
To characterize the electroretinographic response of the macula by multifocal electroretinography (mfERG) in nonproliferative diabetic retinopathy (NPDR) with and without diabetic macular edema (DME) and correlate it with best-corrected visual acuity (BCVA) and foveal thickness on spectral-domain optical coherence tomography (SD-OCT).

PATIENTS AND METHODS:
Prospective, observational case series. Forty eyes of 22 patients with treatment-naïve NPDR underwent recording of BCVA, fundus fluorescein angiography (FFA), and SD-OCT. Groups A and B were classified as 20 eyes each having NPDR with DME (central foveal thickness [CFT] ≥ 275 μm) and without DME (CFT < 275 μm), respectively. First-order kernel mfERG responses recorded according to ISCEV guidelines were grouped into five concentric rings centered on the fovea for analysis.

RESULTS:

Mean P1 and N1 amplitudes (nv/deg
2
) were significantly decreased compared to normal values in each of the five rings in both groups (
P
< .01); however, the values between the two groups were comparable. BCVA was significantly and positively correlated with P1 (r = 0.454,
P
= .003) and N1 amplitude (r = 0.468,
P
= .002) and significantly and negatively correlated with P1 (r= −0.534,
P
< .01) and N1 implicit times (r= −0.570,
P
< .01) in all patients. P1 (r= −0.531,
P
< .01) and N1 amplitude (r= −0.367,
P
= .02) in the central ring of mfERG had a significant negative correlation with macular thickness in the corresponding foveal ring of SD-OCT in all patients.

CONCLUSIONS:
mfERG reflects retinal dysfunction irrespective of the occurrence of DME in patients with NPDR. Correlation with BCVA reinforces that mfERG should be used to objectively assess the macular function in these patients.

[
Ophthalmic Surg Lasers Imaging Retina
. 2018;49:780–786.]
A Novel Approach to In-Office Air-Fluid Exchange Utilizing a 27-Gauge Valved Trocar Cannula
Authors: Prenner Sofia , Fine Howard F. 
Published: November 2018

BACKGROUND AND OBJECTIVE:
To describe a new approach for in-office air-fluid exchange.

PATIENTS AND METHODS:
This manuscript describes a procedural technique. A retrospective chart review of three patients on whom the procedure was performed is presented.

RESULTS:
The authors have performed this novel procedure on three eyes of three patients. All patients were followed for at least 3 months after the procedure. No short-term complications occurred, and no secondary procedures were required to achieve a near-complete air-fluid exchange.

CONCLUSION:
This novel technique is a reliable and reproducible procedure that allows for in-office air-fluid exchange with good results in this small cohort of patients.

[
Ophthalmic Surg Lasers Imaging Retina
. 2018;49:799–801.]
Arctic Response Technology JIP Key Achievements and Final Deliverables
Authors: Winkler Mitchell M. , Jahre-Nilsen Catherine 
Published: November 2018

Abstract
The Arctic Response Technology Joint Industry Programme (ART JIP) was completed in 2017. The research program focused on priority areas where new research and technology development had the best chance of significantly advancing in the near future, the capability to respond to spills in the presence of ice as well as in open water. Research topics were chosen to encompass all the key elements of an integrated offshore response system: In Situ Burning, Dispersants, Remote Sensing, Environmental Effects, Trajectory Modelling, and Mechanical Recovery. The ART JIP was initiated by nine oil and gas companies and the work executed by leading scientific, engineering, and consulting firms across the globe.
The research consolidated a vast amount of existing knowledge in these six key areas to provide a robust and more accessible baseline for future regulators, users and industry representatives concerned with assessing, approving, planning, executing and providing oversight to ensure safe Arctic drilling and production programmes in the future.
The scientific research added a significant new knowledge base to the existing peer-reviewed literature on oil spill impacts, herders and burning, dispersants, remote sensing and trajectory modelling. With this new information, these tools can more confidently take their place as response strategies alongside traditional methods such as mechanical recovery.
As a result of past efforts and now the ART JIP, a range of operationally proven tools is available to suit specific regional environments, seasons, drilling and production programmes. A fundamental objective of the ART JIP was to make all results from the research effort publicly available. The results, findings, and strategic implications have been extensively documented and the results can be found on the ART JIP's legacy website, conference proceedings, and journals.
The Diverse Family of MR1-Restricted T Cells
Authors: Gherardin Nicholas A. , McCluskey James , Rossjohn Jamie , Godfrey Dale I. 
Published: November 2018

Abstract
Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR α- and TCR β-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity.
Stalking of social healthcare workers: Preliminary results of a study conducted in Sardinia, Italy
Authors: Manunza Francesca , Mastronardi Vincenzo M. , Calderaro Monica 
Published: November 2018

Several studies have highlighted that particular social and professional categories are at higher risk of being victim of stalking. Physicians and healthcare workers in general are at risk of being harassed while practising their profession, especially by their patients; this risk has been shown to be higher for psychiatrists and psychotherapists. According to a recent study, 21% of psychiatrists has been a victim of stalking; length of stalking behaviour on healthcare workers varies from a few weeks to several years. Aim of the present work is to gain a better understanding and a highlight on the frequency with which stalking occurs toward social and healthcare workers of public health facilities in Sardinia. After a review of literature, an anonymous questionnaire, prepared ad-hoc, has been administered to a sample of 265 healthcare workers in Sardinia: out of the 210 who have answered, we have taken into consideration 187 healthcare workers, have excluded 23 operators (psychiatric rehabilitators, professional educators, social workers) and chosen to analyze victimization suffered by psychiatrists, psychologists, nurses, social healthcare workers. In our sample the subjects who reported harassments comparable to the crime of stalking are represented by 30 healthcare workers out of the total sample of 187 (16%). Females are the most frequently represented with a ratio of 23/30 (77%) compared to males 7/30 (23%). The risk of being a victim of harassment was higher for the group of psychiatrists and psychologists than for nurses. Among the victims, 18 were psychiatrists (60%), 3 psychologists (10%), and 9 nurses (30%). Healthcare professionals are at high risk of victimization. The main tool available to the services is the team approach to multi-problematic cases, avoiding isolation of the dyad designated operator-patient. The feeling of impotence and isolation that is frequent in the victims of stalking, as shown also in our sample, is highlighted by several studies in which 10% of the victims interviewed claims to have thoughts of suicide as a way out.
The new Popper's epistemology of the criminal trial. Strong scientific evidence and reduction of clues to procedural conjectures. Legal medicine (in memory of Ferdinando Imposimato)
Authors: Francione Gennaro 
Published: November 2018

Report presented to the International Congress “Present and future of criminology in the criminal system”, Rome, April 2018, with a dedication to Professor Ferdinando Imposimato, judge, senator, lawyer and university Professor.
The first Renaissance was represented by the Enlightenment movement, which, virtually crushing the inhuman justice of the inquisitors, sowed the seeds for a revolution of themes still waiting to be realized with our second Renaissance. Emblematic is the fact that even today, a process based on circumstantial evidence takes place with the risk to condemn an innocent, subverting Voltaire's quote: "It is better to risk saving a guilty person than to condemn an innocent one". And, as for the prison, the current hindering lagers - euphemistically defined hotels (8 people in a cell)- betray the code of Beccaria: "The purpose of the punishment is not to torment and afflict a sentient being. The aim is nothing more than to prevent the offender from doing further harm to his compatriots and to keep other people from doing the same. And then: "The safest but most difficult means of preventing crimes is to improve education".
Burning-derived vanillic acid in an Arctic ice core from Tunu, northeastern Greenland
Authors: Grieman Mackenzie M. , Aydin Murat , McConnell Joseph R. , Saltzman Eric S. 
Published: November 2018

Abstract. In this study, vanillic acid was measured in the Tunu ice core from northeastern Greenland in samples covering the past 1700 years. Vanillic acid is an aerosol-borne aromatic methoxy acid, produced by the combustion of lignin during biomass burning. Air mass trajectory analysis indicates that North American boreal forests are likely the major source region for biomass burning aerosols deposited to the ice core site. Vanillic acid levels in the Tunu ice core range from  < 0.005 to 0.08 ppb. Tunu vanillic acid exhibits centennial-scale variability in pre-industrial ice, with elevated levels during the warm climates of the Roman Warm Period and Medieval Climate Anomaly, and lower levels during the cooler climates of the Late Antique Little Ice Age and the Little Ice Age. Analysis using a peak detection method revealed a positive correlation between vanillic acid in the Tunu ice core and both ammonium and black carbon in the North Greenland Eemian Ice Drilling (NEEM) project ice core from 600 to 1200 CE. The data provide multiproxy evidence of centennial-scale variability in North American high-latitude fire during this time period.
O efeito da cinesioterapia e hidrocinesioterapia na dor, capacidade funcional e fadiga em mulheres com fibromialgia
Authors: Sousa Bárbara Samille Moreira de , Sampaio Walber Tenório , Oliveira Mayleize Neves de , Brandão Ana Denise , Porto Elias Ferreira , Bianchi Cesário , Kümpel Claudia 
Published: November 2018

Introdução: A Fibromialgia (SFM) é definida como uma síndrome clínica que se caracteriza por dor difusa pelo corpo todo. Objetivo: avaliar os efeitos da cinesioterapia no solo e da hidrocinesioterapia na melhora da dor, fadiga muscular, e capacidade funcional desses pacientes. Métodos: É um estudo prospectivo cegado, onde foram avaliadas 17 pacientes do sexo feminino com SFM, e divididas em dois grupos: grupo I (cinesioterapia), e grupo II (hidrocinesioterapia). Avaliados através da EVA, escala de Chalder e teste de caminhada de seis minutos. Resultados: Na avaliação da dor, a média da pré e pós reabilitação para Gi e GII foram 7,57±1,38 e 3,83±1,34 6,9±1,57 e 4,33±1,88 respectivamente. Quanto à capacidade funcional pré e pós reabilitação do GI foi 492,86±50,51 e 498,67±71,47. Para GII foi 460,30±46,09 546,17±56,16. Em relação a fadiga global pré pós reabilitação GI foi 3,5±0,5 e 1±1,5 do GII foi 3,5±0,5, e 2,5±0,95. Conclusão: Ambas as abordagens são eficazes no tratamento da SFM, porém, a cinesioterapia no solo foi mais eficaz na redução da dor e da fadiga. A melhora da capacidade funcional esteve mais relacionada a hidrocinesioterapia.
Keefektifan ekstrak daun kecubung (Datura metel L.) dalam menghambat penetasan dan siklus hidup Aedes aegypti L.
Authors: Martini Martini , Astriana Novi , Yuliawati Sri , Hestiningsih Retno , Purwantisari Susiana 
Published: November 2018

Kecubung (Datura metel L.) merupakan jenis tanaman perdu yang mempunyai batang kayu, keras, dan tebal. Daun kecubung mengandung senyawa kimia alkaloid, saponin, flavonoida, dan fenol. Dilihat dari kandungan kimianya daun kecubung memiliki potensi sebagai insektisida nabati yang dapat menggantikan penggunaan insektisida sintetik. Penggunaan insektisida sintetik dalam mengendalikan populasi Aedes aegypti L. telah menimbulkan dampak negatif, diantaranya adalah polusi lingkungan, masalah kesehatan masyarakat, dan resistensi vektor. Tujuan penelitian ini adalah untuk mengetahui keefektifan ekstrak daun kecubung dalam menghambat penetasan telur dan siklus hidup Ae. aegypti. Jenis penelitian ini adalah true experiment dengan 4 kali pengulangan dan perlakuan 6 konsentrasi, yaitu 125, 250, 500, 750, 1.000, dan 1.250 ppm. Subyek penelitian adalah telur Ae. aegypti fertil. Setiap unit perlakuan ditempatkan 25 telur sehingga jumlah total telur yang dibutuhkan adalah 800 butir telur nyamuk. Metode yang digunakan untuk ekstraksi adalah maserasi. Hasil analisis probit menunjukkan aktivitas insektisida ekstrak daun kecubung dengan nilai LC50 sebesar 199,340 ppm dan nilai LC90 sebesar 749,080 ppm. Hasil uji ANOVA menunjukkan terdapat perbedaan rata-rata jumlah telur yang tidak menetas akibat paparan ekstrak daun kecubung (P = 0,001). Persentase kegagalan penetasan telur Ae. aegypti paling rendah pada konsentrasi 125 ppm, yaitu sebesar 41% dan yang paling tinggi pada konsentrasi 1250 ppm, yaitu sebesar 98%. Daya hidup larva, pupa, dan nyamuk paling tinggi pada konsentrasi 125 ppm, yaitu masing-masing sebesar 49,18%; 55,17%, dan 43,75%. Sebagai kesimpulan, ekstrak daun kecubung memiliki potensi sebagai insektisida nabati terhadap telur Ae. aegypti.
Perfiles de afrontamiento y estrés académico en estudiantes universitarios
Authors: González Cabanach Ramón , Souto-Gestal Antonio , González-Doniz Luz , Franco Taboada Victoria 
Published: November 2018

Introducción: los efectos del estrés académico se encuentran mediados por las estrategias de afrontamiento de los estudiantes. Sin embargo, existe poca evidencia acerca de la asociación entre los diferentes perfiles de afrontamiento y las respuestas psicofisiológicas de estrés. El objetivo de la presente investigación es analizar la variabilidad de las respuestas psicofisiológicas de estrés en función del perfil de afrontamiento activo que presenta el estudiante universitario. Método: participaron en el estudio 1195 estudiantes universitarios, el 71% mujeres, con una edad media de 21.57 años (DT=3.63). Se administró la escala de afrontamiento de estresores (ACEA) y la escala de respuestas de estrés (RCEA) del cuestionario de estrés académico. Resultados: un quick cluster clasificó a los estudiantes en 4 grupos. Dos de los grupos mostraron un alto grado de afrontamiento activo (afrontamiento activo [AA] y afrontamiento activo y social [AAS]), mientras que los otros dos reportaron niveles bajos (afrontamiento social [AS] y bajo afrontamiento activo y social [BAS]). El ANOVA mostró que los estudiantes que emplean estrategias de afrontamiento activo (AA y AAS) informan de menores respuestas psicofisiológicas de estrés en comparación aquellos con bajo nivel de afrontamiento activo (AS y BAS), tanto físicas (agotamiento físico y alteraciones del sueño), como conductuales (irascibilidad) y cognitivas (intrusión de pensamientos negativos). La función mediadora del apoyo social se muestra importante únicamente entre los grupos con niveles bajos de afrontamiento activo (AS y BAS). Conclusión: los programas de prevención e intervención en el estrés académico deberían tener en cuenta estas diferencias en su diseño e implementación.
Best Practices in the Internationalization of Higher Education at Petra Christian University
Authors: Hardjito Djwantoro , Intan Rolly , . Meilinda 
Published: November 2018

Petra Christian University (PCU) is located in Surabaya, the second largest city in Indonesia. In its 57 years of age, PCU has been chosen as the Best Private University in Indonesia for the last three consecutive years from 2015-2017, by the Indonesian Ministry of Research, Technology and Higher Education. Currently, PCU has approximately 8700 students with about 320 full-time lecturers and professors.
With the vision to be a Caring and Global University with commitment to Christian values, and by providing holistic education, PCU graduates are expected to possess cultural excellence, alongside with academic, emotional, moral and spiritual excellences. In this regard, students should have opportunities to learn and to be engaged with other foreign cultures in order to prepare their roles in global era. With this in mind, PCU strives to place internationalization as one of its priorities. A number of initiatives and systems have been laid-down to foster the pace of internationalization at PCU.
Disruption, Globalization and the Changing Context of Education
Authors: Viswanathan Govindasamy 
Published: November 2018

Education is the process of facilitating learning, acquisition of knowledge, skills, values, beliefs and habits. It is expected to prepare students for facing challenges of life. And higher education in particular is the process of molding oneself to be suitable for a career in specialized area of interest. It is clear that education offered should depend on the individuals undergoing education and the need posed by the world. Both the “individuals’ and the “need” are changing with time and hence the process of education also should be changing with time, else it will become outdated and useless.
All educators need to be up-to-date and to keep pace with the changing world and the increasing demand. This is a challenging task.
Reception and willingness to share pseudo‐profound bullshit and their relation to other epistemically suspect beliefs and cognitive ability in Slovakia and Romania
Authors: Čavojová Vladimíra , Secară Eugen‐Călin , Jurkovič Marek , Šrol Jakub 
Published: November 2018

SummaryPropensity to judge randomly generated, syntactically correct (i.e., bullshit) statements as profound is associated with a variety of conceptually relevant variables (e.g., intuitive cognitive style and supernatural beliefs). Besides generalizing these findings to a different cultural setting, we examined the relationships to sharing the bullshit on social media. Rating nonsense as profound was associated with a lower cognitive ability; a stronger belief in the paranormal, alternative medicine, and conspiracies; and ontological confusion. The more profound a statement was rated to be, the more likely it was to be shared, and propensity for sharing bullshit was predicted by ontological confusion and religious beliefs. Bullshit receptivity and sharing may be closely related to several dimensions of epistemically suspect beliefs; people with these propensities are relatively open to vague statements resembling New Age spirituality.
Near‐Infrared‐Triggered Release of Ca2+ Ions for Potential Application in Combination Cancer Therapy
Authors: Chen Qiaoshan , Huo Da , Cheng Haoyan , Lyu Zhiheng , Zhu Chunlei , Guan Baohong , Xia Younan 
Published: November 2018

AbstractCalcium ion (Ca2+), an abundant species in the body, is a potential therapeutic ion with manageable side effects. However, the delivery of such a highly charged species represents a great challenge. Here, a nanosystem based on Au nanocages (AuNCs) and a phase‐change material (PCM) for delivering calcium chloride (CaCl2) into cancer cells and thereby triggering cell death upon near‐infrared (NIR) irradiation is demonstrated. In the absence of NIR irradiation, the nanosystem, denoted CaCl2‐PCM‐AuNC, shows negligible cytotoxicity because the Ca2+ ions are fully encapsulated in a solid matrix. Upon NIR irradiation, the Ca2+ ions are swiftly released due to the melting of PCM matrix in response to photothermal heating. The sudden increase in intracellular Ca2+ causes disruption to the mitochondrial Ca2+ homeostasis and thus the loss of mitochondrial membrane potential, subsequently resulting in cell apoptosis. This nanosystem provides a new method for cancer treatment by tightly managing the intracellular concentration of a physiologically essential element.
Crumpled Ir Nanosheets Fully Covered on Porous Carbon Nanofibers for Long‐Life Rechargeable Lithium–CO2 Batteries
Authors: Xing Yi , Yang Yong , Li Daohao , Luo Mingchuan , Chen Nan , Ye Yusheng , Qian Ji , Li Li , Yang Dongjiang , Wu Feng , Chen Renjie , Guo Shaojun 
Published: November 2018

AbstractAprotic Li–CO2 batteries are a new class of green energy storage and conversion system, which can utilize the CO2 from the atmosphere in an environmentally friendly way. However, the biggest problem of the existing Li–CO2 batteries is that they suffer from high polarization and poor cycling performance, mainly caused by the insulating and insoluble discharge product, Li2CO3. Herein, this study reports the synthesis of wrinkled, ultrathin Ir nanosheets fully anchored on the surface of N‐doped carbon nanofibers (Ir NSs‐CNFs) as an efficient cathode for improving the performance of lithium–CO2 batteries. The battery can be steadily discharged and charged at least for 400 cycles with a cut‐off capacity of 1000 mAh g−1 at 500 mA g−1. Meanwhile, the cathode can effectively reduce the charge overpotential by showing a charge termination voltage below 3.8 V at 100 mA g−1, which is the smallest charge overpotential reported to date. The ex situ analysis of the intermediate products reveals that during the discharge process, Ir NSs‐CNFs can greatly stabilize amorphous granular intermediate (probably Li2C2O4) and delay its further transformation into thin plate‐like Li2CO3, whereas during the charge process, it can make Li2CO3 be easily and completely decomposed, which is the key in greatly improving its performance for lithium–CO2 batteries.