bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subaerial sulfate mineral formation related to acid aerosols at the Zhenzhu Spring, Tengchong, China
Authors: Luo Lianchao , Wen Huaguo , Zheng Rongcai , Liu Ran , Li Yi , Luo Xiaotong , You Yaxian 
Published: January 2019

AbstractThe Zhenzhu Spring, located in the Tengchong volcanic field, Yunnan, China, is an acid hot spring with high SO42−concentrations and intense acid aerosol generation. In order to understand the formation mechanism of sulfate minerals at the Zhenzhu Spring and provide a better insight into the sulfur isotope geochemistry of the associated Rehai hydrothermal system, we investigated the spring water hydrochemistry, mineralogy and major-element geochemistry of sulfate minerals at the Zhenzhu Spring together with the sulfur-oxygen isotope geochemistry of sulfur-containing materials at the Rehai geothermal field and compared the isotope results with those in other steam-heated environments. Subaerial minerals include a wide variety of sulfate minerals (gypsum, alunogen, pickeringite, tamarugite, magnesiovoltaite and a minor Mg–S–O phase) and amorphous SiO2. The δ34S values of the subaerial sulfate minerals at the Zhenzhu Spring varied subtly from –0.33 to 1.88‰ and were almost consistent with the δ34S values of local H2S (–2.6 to 0.6‰) and dissolved SO42−(–0.2 to 5.8‰), while the δ18O values (–8.94 to 20.1‰) were between that of the spring waters (–10.19 to –6.7‰) and atmospheric O2(~23.88‰). The results suggest that most of the sulfate minerals are derived from the oxidation of H2S, similar to many sulfate minerals from modern steam-heated environments. However, the rapid environmental change (different ratio of atmospheric and water oxygen) at the Zhenzhu Spring accounts for the large variation of δ18O. The formation of subaerial sulfate minerals around the Zhenzhu Spring is related to acid aerosols (vapour and acid water droplets). The intense activity of spring water around vents supply the aerosol with H2SO4(H2S oxidation and acid water droplets formed by bubble bursting) and few cations. Deposition of the acid sulfate aerosol forms the acid condensate, which attacks the underlying rocks and releases many cations and anions to form subaerial sulfate minerals at the Zhenzhu Spring.
Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms
Authors: Jackson Shaun P. , Darbousset Roxane , Schoenwaelder Simone M. 
Published: January 2019

Abstract
Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a broad range of human disorders. It is well recognized clinically in the context of superficial thrombophlebitis (thrombosis and inflammation of superficial veins); however, it is more dangerous when it develops in the microvasculature of injured tissues and organs. Microvascular thrombosis with associated inflammation is well recognized in the context of sepsis and ischemia-reperfusion injury; however, it also occurs in organ transplant rejection, major trauma, severe burns, the antiphospholipid syndrome, preeclampsia, sickle cell disease, and biomaterial-induced thromboinflammation. Central to thromboinflammation is the loss of the normal antithrombotic and anti-inflammatory functions of endothelial cells, leading to dysregulation of coagulation, complement, platelet activation, and leukocyte recruitment in the microvasculature. α-Thrombin plays a critical role in coordinating thrombotic and inflammatory responses and has long been considered an attractive therapeutic target to reduce thromboinflammatory complications. This review focuses on the role of basic aspects of coagulation and α-thrombin in promoting thromboinflammatory responses and discusses insights gained from clinical trials on the effects of various inhibitors of coagulation on thromboinflammatory disorders. Studies in sepsis patients have been particularly informative because, despite using anticoagulant approaches with different pharmacological profiles, which act at distinct points in the coagulation cascade, bleeding complications continue to undermine clinical benefit. Future advances may require the development of therapeutics with primary anti-inflammatory and cytoprotective properties, which have less impact on hemostasis. This may be possible with the growing recognition that components of blood coagulation and platelets have prothrombotic and proinflammatory functions independent of their hemostatic effects.
Local deformation and stiffness distribution in fly wings
Authors: Wehmann Henja-Niniane , Heepe Lars , Gorb Stanislav N. , Engels Thomas , Lehmann Fritz-Olaf 
Published: January 2019

ABSTRACTMechanical properties of insect wings are essential for insect flight aerodynamics. During wing flapping, wings may undergo tremendous deformations, depending on the wings’ spatial stiffness distribution. We here show an experimental evaluation of wing stiffness in three species of flies using a micro-force probe and an imaging method for wing surface reconstruction. Vertical deflection in response to point loads at 11 characteristic points on the wing surface reveals that average spring stiffness of bending lines between wing hinge and point loads varies ∼77-fold in small fruit flies and up to ∼28-fold in large blowflies. The latter result suggests that local wing deformation depends to a considerable degree on how inertial and aerodynamic forces are distributed on the wing surface during wing flapping. Stiffness increases with an increasing body mass, amounting to ∼0.6 Nm−1 in fruit flies, ∼0.7 Nm−1 in house flies and ∼2.6 Nm−1 in blowflies for bending lines, running from the wing base to areas near the center of aerodynamic pressure. Wings of house flies have a ∼1.4-fold anisotropy in mean stiffness for ventral versus dorsal loading, while anisotropy is absent in fruit flies and blowflies. We present two numerical methods for calculation of local surface deformation based on surface symmetry and wing curvature. These data demonstrate spatial deformation patterns under load and highlight how veins subdivide wings into functional areas. Our results on wings of living animals differ from previous experiments on detached, desiccated wings and help to construct more realistic mechanical models for testing the aerodynamic consequences of specific wing deformations.
Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch
Authors: Papadopoulos Dimitrios K. , Skouloudaki Kassiani , Engström Ylva , Terenius Lars , Rigler Rudolf , Zechner Christoph , Vukojević Vladana , Tomancak Pavel 
Published: January 2019

ABSTRACT
The variability in transcription factor concentration among cells is an important developmental determinant, yet how variability is controlled remains poorly understood. Studies of variability have focused predominantly on monitoring mRNA production noise. Little information exists about transcription factor protein variability, as this requires the use of quantitative methods with single-molecule sensitivity. Using Fluorescence Correlation Spectroscopy (FCS), we have characterized the concentration and variability of 14 endogenously tagged TFs in live Drosophila imaginal discs. For the Hox TF Antennapedia, we investigated whether protein variability results from random stochastic events or is developmentally regulated. We found that Antennapedia transitioned from low concentration/high variability early, to high concentration/low variability later, in development. FCS and temporally resolved genetic studies uncovered that Antennapedia itself is necessary and sufficient to drive a developmental regulatory switch from auto-activation to auto-repression, thereby reducing variability. This switch is controlled by progressive changes in relative concentrations of preferentially activating and repressing Antennapedia isoforms, which bind chromatin with different affinities. Mathematical modeling demonstrated that the experimentally supported auto-regulatory circuit can explain the increase of Antennapedia concentration and suppression of variability over time.
Knowledge and factors influencing long acting reversible contraceptive use among women of reproductive age in Nigeria
Authors: Bolarinwa Obasanjo Afolabi , Olagunju Olalekan Seun 
Published: January 2019

Background: Over a month when contraception is used, approximately 48% of unintended pregnancies occur as a result of human error, which is largely due to incorrect use, poor adherence and/or technology failure. Long-acting reversible contraceptive (LARC) methods have been developed to bridge this gap because it’s not dependent on compliance with a pill-taking regimen; remembering to change patch or ring; or fixing an appointment with physicians. The main aim of this study is to examine the characteristics of women associated with use of LARC and also to examine the relationship between knowledge of LARC and its current use. Methods: This study assessed the PMA2020 secondary dataset using female datasets from PMA 2016 (Round 3) exercise. PMA 2016 was a survey carried out in seven states of Nigeria. The target population for this study was women of reproductive age (15-49 years) currently using any method of contraception prior to the survey. The weighted sample size of women meeting inclusion criteria in this study is 1927. The data were analyzed using frequency distribution, chi-square and logistic regression. Results: The results showed that 21.0% of women were using traditional methods. Concerning LARC methods, the table showed that 14.8% of the sampled women were using LARC methods. Findings further revealed that at both levels of analysis there is a significant relationship (P<0.05 and P=0.00 for binary and multivariable logistic regression, respectively) between knowledge of LARCs and uses in this study. This means that the use of LARC is being influenced by its knowledge among women of reproductive age in Nigeria. Conclusions: This study concludes that 14.8% of women using any methods of contraceptive were using LARC. Additionally, after controlling for other confounding factors, level of education, age of women, household wealth and number of living children were significantly associated with using LARC.
O uso de grupos do WhatsApp por comunidades de jogo: impulsionando a comunicação e estreitando laços sociais
Authors: Gomes Batista Micheline Dayse , Barbosa Felix Vilma 
Published: January 2019

Este trabajo tiene como objetivo analizar las posibilidades comunicacionales y de sociabilización en comunidades de juegos digitales, que incluyen desde chat rooms en el ambiente del propio juego a grupos en aplicativos de mensajes instantáneos como el WhatsApp. Partimos de un relato etnográfico en el juego Elves vs. Dwarves para demostrar que los grupos de WhatsApp permiten llevar la experiencia del juego más allá del propio juego, ampliando las prácticas cotidianas de los jugadores.
Branch-and-Cut for the Split Delivery Vehicle Routing Problem with Time Windows
Authors: Bianchessi Nicola , Irnich Stefan 
Published: January 2019

The split delivery vehicle routing problem with time windows (SDVRPTW) is a notoriously hard combinatorial optimization problem. First, it is hard to find a useful compact mixed-integer programming (MIP) formulation for the SDVRPTW. Standard modeling approaches either suffer from inherent symmetries (mixed-integer programs with a vehicle index) or cannot exactly capture all aspects of feasibility. Because of the possibility to visit customers more than once, the standard mechanisms to propagate load and time along the routes fail. Second, the lack of useful formulations has rendered any direct MIP-based approach impossible. Up to now, the most effective exact algorithms for the SDVRPTW have been branch-and-price-and-cut approaches using path-based formulations. In this paper, we propose a new and tailored branch-and-cut algorithm to solve the SDVRPTW. It is based on a new, relaxed compact model, in which some integer solutions are infeasible for the SDVRPTW. We use known and introduce some new classes of valid inequalities to cut off such infeasible solutions. One new class is path-matching constraints that generalize infeasible-path constraints. However, even with the valid inequalities, some integer solutions to the new compact formulation remain to be tested for feasibility. For a given integer solution, we build a generally sparse subnetwork of the original instance. On this subnetwork, all time-window-feasible routes can be enumerated, and a path-based residual problem then solved to decide on the selection of routes, the delivery quantities, and thereby the overall feasibility. All infeasible solutions need to be cut off. For this reason, we derive some strengthened feasibility cuts exploiting the fact that solutions often decompose into clusters. Computational experiments show that the new approach is able to prove optimality for several previously unsolved instances from the literature. The e-companion is available at https://doi.org/10.1287/trsc.2018.0825 .
Aggresive Mass Excision Through Nasolabial Fold Areain the Treatment of Facial Neurofibromatosis : Case Report
Authors: Handayani Siti , Bangun Kristaninta , Soetjipto Soepodo Fernita Leo 
Published: January 2019

Neurofibromatosis type 1 is a rare disease which can manifest itself by the development of plexiform neurofibromatosis, with craniofacial deformities. In this paper, we propose special consideration in excision nasolabial fold mass to help lifting procedures in neurofibromatosis patients. We are reporting two case, both presented with von Recklinghausen’s disease, a 21 years old male patient with neurofibromatosis in his right hemifacial for which he had been operated on five times previously at other center, and a 24 years old male with neurofibromatosis in his left hemifacial. After several stages of reconstruction which started with nasolabial fold mass excision, the result was satisfactory, by using the multiple stage repair, it was done until the end result is similar to anatomical form. The mass debulking procedures for these patients, which started with Nasolabial Fold mass excisison are continued with durable lifting procedures. This method gives results a satisfactory lifting procedure.
Problems In Cleft Lip Nose Patients Undergoing Augmentation Rhinoplasty With Rib Graft : A Case Report
Authors: Kusumastuti Nadia , Sudjatmiko Gentur 
Published: January 2019

Correction of a cleft lip nasal deformity remains a challenging procedure in reconstructive surgery. Many different procedures have been suggested to address the problem, but few techniques have worked well and consistently. We present a case of secondary cleft nasal deformity after repair of unilateral complete cleft lip and palate on the left side. The corrective procedures carried out included closed method rhinoplasty and dorsal nasal augmentation with rib graft which was fixed to the nasal septum with needle. The patient showed satisfactory immediate post-operative result, with correction of depressed alar base and satisfying dorsal and tip projection. However, 5 months post operative result showed deviation of nasal tip to the cleft side, which we suspected was due to: warping of the rib graft, soft tissue deficiency in the cleft side which exerts pulling forces to the warping graft, and lack of rigid fixation of the graft. After appraising pitfalls encountered in augmenting nasal dorsum of cleft patients with rib graft, we concluded that some preventive measures need to be done to avoid those problems, namely: balanced cross sectional carving of rib graft, cantilever graft with plate and screw to the nasal bone, and addressing pulling force from lack of soft tissue in the cleft side by adding columellar strut graft or alar contour graft.
Recurrent Cranial Bone and Scalp Defect : A Case Report
Authors: Hakim Intan Friscilla , Sudjatmiko Gentur 
Published: January 2019

Partial defect of the cranial bone and scalp remains a dificult problem for surgeons. Longterm morbidity is due to dif!culty in finding the right material for closure and the resulting repeated surgery. This paper discusses the effectiveness of honey application as a simple and effective method for scalp defect treatment. One case of a patient with partial and cranium defect was referred to Cipto Mangunkusumo hospital with several prior attempt to close the defect with an acrylic implant. The cultured swab on patient revealed MRSA. Application of honey to the raw surface on the cranial defect shows resulting spontaneous epithelialization without clinical evidence of local infection. The use of honey as a topical treatment for cranial and scalp defect provide a safe and effective alternative method for closing the wound secondarily.
Speech Outcome Evaluation After Two-Flap Palatoplasty In Plastic Surgery Division Cipto Mangunkusumo Hospital: A Retrospective study
Authors: Bangun Kristaninta , Handayani Siti , Djoenaedi Intania , Wahyuni Luh Karunia 
Published: January 2019

One of the primary goal of cleft palate repair is to provide an intact mechanism for normal speech production. The purpose of this study is to evaluate the two-flap mucoperiosteal palatoplasty procedure on speech outcomes in patients undergoing surgical repair before the age of 2 years. A retrospective analysis study was done on 22 children with complete unilateral cleft palate (with or without cleft lip) who underwent two-flap palatoplasty between year 2002 to 2006 at Cipto Mangunkusumo Hospital. Evaluation was performed by a speech pathologist for pattern of articulation, hypernasality, intelligibility, and velopharyngeal competence. Palatoplasty were performed after 2 year-old in 11 patients and before 2 year-old in 11 patients. Speech of the 22 children postpalatoplasty was evaluated perceptually from standardised tape recordings. Velopharyngeal competence in patients who underwent palatoplasty before 2 year-old compared to after 2 year-old were 72.7% good, 18.2% fair and 9.1% poor versus 54,5% good, 9,1% fair and 36,4% poor respectively. Two-flaps mucoperiosteal palatoplasty performed before the age of 2 years old shows better spepolech outcome in all parameters, although the numbers are not statistically significant. Further prospective study with larger sample is needed.
The Rational of Colloid Requirements in Burn Patients : Literature Reviews
Authors: Wardhana Aditya , Septrisya Shiera 
Published: January 2019

Backgrounds: For decades, fluid resuscitation in burn patients has been done as a routine process; most clinicians continue to adjust volume requirements using Parkland formula for the initial 24- hour period. In a variety of situations, there is increasing recognition of using significantly greater volumes than anticipated by the Parkland formula; clinicians tend to escalate volume requirements to drive the urine output to the higher end of any desired range. This excessive fluid could result in numerous edema-related complications, which currently coined as “fluid creep” phenomenon. Besides optimizing titration of fluid infusion rate, there have been studies of earlier and more liberal use of colloids, and even the use of hypertonic saline. The overall goal is to reduce the resuscitation volume requirements and subsequently, early edema formation.Conclusion: Current research in fluid resuscitation now concentrates on approaches to minimize fluid creep, including tighter control of fluid infusion rate. The single most important principle in using the Parkland formula, however, is that it should be used only as a guideline. The resuscitation rate and volume must be continually adjusted based on the response of the patient. Studies have been demonstrated to compare the use of crystalloids with early colloid in the first 24 hours post burn. At present, there are still wide variations in the timing of colloid resuscitation. However, use of 5% albumin in the second 24 hours seems to be an acceptable alternative.
Serum IgG, and IgM Levels in Children with Febrile Convulsions
Authors: Deda Gulhis , Karagol Ugur , Gurer Ya Vuz 
Published: January 2019

At the Dr. Sami Ulus Children's Hospital Ankara, Turkiye, 20 patients, twelve being between 6 months-2 year old and eight being between 2-4 years, with their first febrile convulsions (FC) were examined for serum IgG, IgA, IgM levels during the period of March 1989-]uly 1989. Twenty healthy children were used as controls, seven being between 6 months-2 years old and thirteen being between 2-6 years. The serum IgG, IgA and IgM levels of the patients between 6 months-2 years were 805.000 + 307.8984 mg/ dl, 49.7167 + 27.9807 mg/dl and i55.1833 + 62.9696 mg/dl respecttvelly.
The serum IgG, IgA and IgM levels of the patients between 2-4 years were : 989.1250 ± 314.5359 mg/dl, 92.6125 ± 34.5663 mg/dl and 159.8750 ± 45.6647 mg.ldl respectivelly. The mean IgA levels of the 12 FC patients between 6 months-2years were 49.7167 ± 27.9807 mg/dl and the mean level of IgA in the age matched control group was 81.0427± 31.3551 mg/dl and the difference between them was statistically significant (p <0. 005).
We conclude that FC under 2 years of age is associated with low serum IgA levels.
Congenital Hypertrophic Pyloric Stenosis: A Case at the Gunung Wenang Hospital Manado - North Sulawesi Indonesia
Authors: Salendu S. M. , B. Abdullah 
Published: January 2019

On a baby girl of 4 weeks old with the dtagnosts of congenital hypertrophic pyloric stenosis, an extremely rare case in our Hospital, surgical operation was done using the Fredet Ramsted method.
The main complaint was frequent vomiting. The diagnosis was based on projectile vomiting, retarded growth, constipation, moderate dehydration and was confirmed by barium meal study.
Ten days after the operation, she was discharged in a good condition.
Estimated Birth Weight by current Weight-and Age During the First Five Days of Life
Authors: Wilopo Siswanto Agus , Hakimi Mohammad , Surjono Achmad 
Published: January 2019

In the developing countries, measurement of birth weight is subjected to methodological problems. The main issue is the difficulty of measuring birth weight soon after delivery. Two relevant questions are proposed by this study : 1) can a birth weight be estimated several hours or days after a baby was delivered ?, and 2) can an estimated birth weight be collected by paramedical personnel with reliable results?
To answer these questions, we conducted a study at Dr. Sardjito Hospital, Yogyakana, to evaluate agreement between two paramedical personnel in the routine measurements of neonatal weight in the rooming-in ward. The behavior of these two paramedical personnel was observed from one month when they examined 32 neonates. Both of them weighed the neonate at 7.00 hours and one weighed the neonate at 15.00 or 21.00 hours. The order of the last two measurements was made alternatingly.
This resulted in 156 pairs of measurement for agreement analysis. There was a strong evidence that the two raters have almost perfect agreement on measuring neonatal weights (intraclass correlation coefficient = 0.978). The second part of this study looked at neonatal weight during the first five days of life. The neonatal weights were measured three times a day up to age of the days. We constructed a formula for estimating their birth weight based on a current neonatal weight and age in days. Birth weight can be estimated using formula : Birth weight ; 51 + 1. 029 x current weight - 10 x age in days. The data fitted very well to this least square estimate with a coefficient of determination (R) = 0.95.