bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Diagnostic Methods in Cardiac Prognosis in Major Abdominal Surgery in Patients with Heart Disease or Over 65 Years Old
Authors: Chomakhidze P. Sh. , Mozzhuhina N. V. , Poltavskaya M. G. , Sedov V. P. , Syrkin A. L. 
Published: January 2019

Purpose of the study. Evaluation of the value of the results of the use of cardiac functional examination methods for the stratification of the risk of developing cardiovascular complications in planned abdominal surgical interventions in patients over 65 years of age or with cardiac pathology.Materials and methods. The study included 179 patients over 65 years of age or with a history of heart disease who underwent elective abdominal surgery. The median age was 70 years. During the operation and for 30 days after it, cardiac complications were recorded: severe (myocardial infarction, stroke, death from cardiovascular disease), others (strokes of exertional angina, ischemic dynamics of the ST segment on the electrocardiogram – ECG – rest, paroxysmal fibrillation / flutter atrial). All patients underwent basic examination – examination, anamnesis, ECG, blood test, assessment of respiratory function, ECG monitoring. Additionally, echocardiography (EchoCG) and ergospirometry (ESM) were performed.Results. In 30 (16.8 %) patients, various MTRs were detected: 6 (3.4 %) of fatal myocardial infarctions, 2 (1.1 %) of fatal strokes; 3 (1.7 %) cases of sudden cardiac death, angina attacks were recorded in 4 (2.2 %) patients, 7 (3.9 %) had ischemic ECG dynamics, 11 (6.1 %) had fibrillation episodes or atrial flutter. Chronic obstructive pulmonary disease, intervention on the colon, blood hemoglobin level <100 g / l, serum creatinine >103 μmol / l, presence of any pathological changes in the resting ECG were associated with the development of SSO; according to EchoCG – VTI (linear velocity integral) in the outflow tract of the left ventricle (LV) <21.5 cm, volume of the left atrium> 57 ml, global LV myocardial deformity is less than 18 %, increase in heart rate (HR) at the 1st minute load test> 27 %, peak oxygen consumption at ESM <15.8 ml / kg / min. The optimal plan for preoperative examination in men is to perform a basic model, and for women it is advisable to combine a basic examination with an ESM or an assessment of the degree of myocardial deformity using the speckle-tracking method for EchoCG.Conclusion. The risk of perioperative MTS during planned abdominal operations in patients older than 65 years or with a history of heart disease is relatively high – 16.8 %. When assessing the risk associated with the operation, it is advisable to additionally conduct echocardiography with VTI assessment in the LV outflow tract and myocardial deformity indicators, as well as ESM with the determination of HR increase in the 1st minute of the test and peak oxygen consumption.
Impact of Depressive Symptoms on All-Cause Mortality in Patients with Congestive Heart Failure After Cardiac Resynchronization Therapy
Authors: Pushkarev G. S. , Kuznetsov V. A. , Fisher Y. A. , Soldatova A. M. , Sapozhnikova А. D. , Enina T. N. 
Published: January 2019

Purpose:to assess the association between depression and all-cause mortality in patients with congestive heart failure (CHF) after cardiac resynchronization therapy (CRT).Materials and Methods.We enrolled in this study 156 patients (mean age 55.3±9.6 years) with CHF and implanted devices for CRT. Mean duration of follow-up was 51.6±33.4 months. The Beck Depression Inventory (BDI) was used to evaluate depressive symptoms (DS); DS were considered absent for a score 0–9, mild to moderate – 10–18, severe – ≥19. For assessment of association of DS and mortality we used multivariate Cox proportional hazards regression model with estimation of hazard ratios (HR) with 95 % confidence intervals (95 %CI).Results. Average Beck Depression Inventory score was 12.4±8.3. In 66 patients (42.3 %) there were no DS, 57 patients (36.5 %) had mild, and 33 (21.2 %) – severe DS. These groups did not differ by main clinical-functional and laboratory indicators. Among individuals without DS prevailed men (90.9 vs. 69.7 % among those with severe DS, p=0.007). Hypercholesterolemia was more frequent in patients with DS (63.3 vs. 43.9 % in patients without DS, p=0.02). During follow-up 33 patients died (21.2 %). Adjusted HR of death from all-causes for DS score as continuous parameter was 1.05, 95 % CI 1.01–1.09, p=0.02. Patients without DS were used as reference (HR=1.0) in analysis of categorical indicator. HR was 1.08, 95 % CI 0.46–2.54, p=0.9 in patients with mild, and 2.92, 95 % CI 1.17–7.32, p=0.02 – with severe DS.Conclusion:DS were associated with gender and hypercholesterolemia. Severe DS were independently associated with all-cause mortality in patients with CHF and implanted CRT devices.
Achieved blood pressure level and target organ damage in post-stroke hypertensive patients
Authors: Lopina E. A. , Libis R. A. 
Published: January 2019

Objective. To assess the impact of the achieved blood pressure level on the structure and function of kidneys, carotid arteries and depression level in hypertensive post-stroke survivors.Design and methods.Carotid arteries and kidneys were assessed by ultrasound study. All parameters including depression level (Hamilton scale) were evaluated depending on the achieved systolic blood pressure level (SBP) in 88 hypertensive patients in acute post-stroke period and at follow-up (8–12 months after stroke). Multiple regression analysis was applied to assess the associations between the factors.Results.Office SBP directly correlates with the creatinine level (r = 0,5; р = 0,01). Moderate direct correlation was found between mean office SBP at the follow-up visit and intima-media thickness (IMT) (r = 0,47; р = 0,004), resistance index of the right common carotid artery (CCA) (r = 0,47; р = 0,006), resistance index of the left CCA (r = 0,5; р = 0,002), and resistance index of the left internal carotid artery (ICA) (r = 0,4; р = 0,02). Regression analysis demonstrated that mean office SBP has an impact on the following parameters: plasma creatinine level (β = 0,43; р = 0,04) and CCA IMT (β = 0,36; р = 0,03). The depression decreased in subjects with SBP 125–134 mmHg.Conclusion. SBP stabilization at the level 125–134 mmHg leads to the decrease in the resistance index of the carotid arteries, improves renal function and reduces depression level in post-stroke survivors.
BIOPRESERVATIF ALAMI DALAM PEMBUATAN EDIBLE FILM KARAGENAN Eucheuma cottonii DENGAN POLIETILEN GLIKOL SEBAGAI PLASTICIZER
Authors: Caroline Clementia , Pratiwi Alberta Rika 
Published: January 2019

Flavored edible film can be made from carrageenan with addition of spices such as sugar, salt, garlic, pepper, and nutmeg. Flavored edible film is an instant spice product innovation to reduce plastic packaging waste. This study aims to determine the effect of adding spices to flavor, solubility, shelf life, antibacterial activity, and fungus growth on edible film. Sensory analysis was to determine the most preferred formulation. Solubility analysis used solution at 75°C and 100°C with oil and without oil. Shelf life analysis used the Accelerared Shelf-Life Testing method at 25°C, 35°C, and 40°C at 75% RH. Antibacterial activity used paper disc diffusion method with Bacillus cereus and Salmonella. Analysis of fungus growth was done with incubation for 24 hours. Flavored edible film consisting of 4 grams of sugar, 4 grams of salt, 1 grams of garlic, 0.2 grams of pepper and 0.2 grams of nutmeg has the highest score of taste and aroma attribute score of 2.20 ± 0.45. Flavored edible film had a significant difference solubility in oil treatment and no significant difference in temperature treatment. Flavored edible film had a shelf life 17 days. Flavored edible film could not inhibit bacterial activity. There was no fungal growth on flavored edible film.
Keywords: flavored edile film, carrageenan, sensory, solubility, shelf life, antimicrobial activity, fungus growth
KARAKTERISTIK FISIK, KIMIA, DAN SENSORIS FRUIT LEATHER PISANG AMBON (Musa paradisiaca S.) DENGAN PENAMBAHAN GULA DAN KARAGENAN
Authors: Marzelly Ages Dwiga , Lindriati Triana , Yuwanti Sih 
Published: January 2019

Fruit leather is a fruit product that has been destroyed and then dried using an oven, so as to form a thin sheet that can be rolled. Fruit leather is generally a thin sheet with a thickness of 2-3 mm, 10-20% water content, plastis texture, was a consistency and a specific taste according to the type of fruit used. Ambon banana has a low pectin content that requires a gel-forming agent to produce the desired texture. One of the commonly used gelling materials is carrageenan. Carrageenan is one of the seaweed derived hydrocolloids that have the ability to form gel and can improved the texture of the product. Carrageenan in gel form must have a dehydrating compound. The common dehydrating agent is sugar. Sugar is a material that can attract water molecules that bind to carrageenan molecules, so that sugars can make a solid gel. The purpose of the study to determine the effect of additional sugar and carrageenan concentration on physical, chemical, and sensory characteristics of fruit leather of Ambon banana and to determine the amount of additional of sugar and carrageenan concentration according to sensory data to produce fruit leather with good sensory characteristics. This study used Completely Randomized Design (RAL) consisting of two factors and three replications. The first factor is the percentage of sugar consisting of 5%, 10%, and 15%. The second factor is the percentage of carrageenan consisting of 0.3%, 0.6%, and 0.9%. Tests carried out include physical characteristics (lighness, texture, tensile strength, and elongation), chemical characteristics (moisture content and ash content), as well as sensory characteristics (color, taste, aroma, texture and overall). The data obtained is processed using a fingerprint analysis analysis of variance using Minitab program V.1.7. If there is a significant difference or influence, then a tukey test on test level α ≤ 5% is used. The result of this research showed that the production of fruit leather of banana Ambon with the concentration of sugar and carrageenan added has a significantly characteristic sensory taste and texture, while no significant effect on the sensory characteristics of color, aroma, overall, physical characteristics (lightness, texture, elongation and tensile strength) and chemical characteristics (ash and water content). Determination of the best treatment in this study was found in A2B1 treatment using 10% sugar concentration and 0.3% carrageenan with a very liking assessment as follows 3% color; aroma 13%; 17% texture; 13% taste; and overall 13% with a total value of 59%.
Keywords: caragenan, fruit leather, sugar
PERANCANGAN MUTU COOKIES LIDAH KUCING UBI JALAR MENGGUNAKAN METODE QFD
Authors: Anjarsari Dini Nastiti , Purnomo Bambang Herry , Nurhayati Nurhayati 
Published: January 2019

UD. Nula Abadi is one of home industry that produces flour and the processed products from sweet potatoes in Bondowoso regency. Lidah kucing is one of UD. Nula Abadi cookies that has potential prospect to develop because these cookies can go into all of marketing segmentation. The aimed of this research are to identify costumer’s quality attribute and to design the quality of lidah kucing UD. Nula Abadi to fulfil costumer’s quality attribute. This research used quality function deployment. The result of this research shows that quality attribute which has being customers priority based on mapping with the technical requirements and competitive profile are taste, packaging material, and texture. The quality design that can be applied for UD. Nula Abadi are keeping the quality of sweet potato, calibrating scale machine, using oven that complete with timer and thermostat, using the packaging material that can be kept the shape of lidah kucing, training the employee to keep production process in accordance with standard operational procedure, having a partnership with local government in terms of promotion and business development.
Keywords: sweet potatoes, cookies, QFD
ANALISIS KANDUNGAN KARBOHIDRAT, GLUKOSA, DAN UJI DAYA TERIMA PADA NASI BAKAR, NASI PANGGANG, DAN NASI BIASA
Authors: Mukti Kana Satria , Rohmawati Ninna , Sulistiyani S. 
Published: January 2019

White rice is the most consumed food by Indonesian people. However, carbohydrate levels in white rice are included in the high glycemic index (73). This makes the white rice less healthy, especially for people with Diabetes Mellitus (DM). Appropriate processing is done to lower carbohydrate and glucose levels in white rice to be more safe to eat, on the contrary is roasting and burning. The purpose of this study was to analyzed the influence and grilling of white rice on carbohydrate, glucose and white rice test after treatment. The research method used was analytic with experimental design (pre-experimental). Sample of acceptance test research from 25 people with DM in Clinic dr. Suherman University of Muhammadiyah Jember. Friedman Test and Wilcoxon Sign Rank Test was used to analyzed, glucose level and analysis used One Way Anova and Post Hoc (Tukey HSD) Test with 5% confidence level (α = 0,05). The results showed that the average of normal rice sugar, grilled rice, and baked rice (X0, X1, and X2) were 39,44%; 34.84%; and 37.45%. Medium for the average glucose levels (X0, X1, and X2) was 2.07%; 2.86%; and 3.38%. The results were performed to measured energy, aroma and texture, white rice (p <α value). Grilled rice had low carbohydrate levels and could be accessed by diabetes, 72.38 grams of grilled rice (25.22 g of carbohydrates and 2.07 g of glucose) could be consumed 1-3 times a day.
Keywords: carbohydrate, glucose, organoleptic test, grilled rice, baked rice, ordinary rice
Proximate Compositions and Biological Activities of Caulerpa lentillifera
Authors: Nofiani Risa , Hertanto Sigit , Zaharah Titin Anita , Gafur Sutarman 
Published: January 2019

Caulerpa lentillifera is an edible and functional seaweed due to its high nutritional compositions and its biological activities. In this study, C. lentillifera was evaluated for its proximate compositions (moisture, ash, protein, lipid and fiber contents) and its biological activities (antimicrobial, anti-oxidant, and toxicity). Moisture content, crude lipid, crude protein, and crude fiber were determined using oven method, soxhlet extraction, semi-micro Kjeldhal, and hydrolysis, respectively. Fresh C. lentillifera of Natuna Island, Indonesia, showed its higher level content of ash, crude lipid, and crude fiber compared to that of fresh C. lentillifera of Penghu, Taiwan. For its biological activity assays, the extracts were prepared from fresh and dry C. lentillifera (FC and DC). Both of the extracts showed the broad spectrum of weak antimicrobial using well-diffusion agar tests and antioxidant activities using a modified linoleic acid emulsion system. The toxicity for both extracts was determined using brine shrimp lethality test. DC extract showed its very low toxicity level and there was no toxicity for FC. Hemolytic activity was determined using red blood assay. Both extracts showed their low hemolytic activities (about 5-13%) for the concentration of 100 and 150 μg/mL, but the activity increased sharply (about 96%) on the concentration of 200 μg/mL. It was concluded that C. lentillifera has a potency as a functional food due to containing secondary metabolites with various biological activities.
The Study of Artemisinin Content in Callus Artemisia annua L. Cultures Elicited with Endophytic Fungi Aspergillus sp.
Authors: Yuliani Farida , Dewi Widyatmani Sih , Yunus Ahmad , Siswanto Usman 
Published: January 2019

Artemisinin, is a sesquiterpene lactone which is originally extracted from the medicinal plant Artemisia annua L. Artemisinin is a very effective antimalarial agent, however it is produced in very low amounts in plants. Chemical synthesis of artemisinin is complicated and not economically feasible. Researchers often use elicitation methods to increase artemisinin content in a laboratory scale with biotic or abiotic elicitor. This study examined the effect of elicitation using endophytic fungi Aspergillus sp on artemisinin content of callus A. annua cultures. Observations were made on its growth, texture and color, chlorophyll content and dry weight. Fungi were isolated from the stem tissue of A. annua and callus were grown on Murashige and Skoog medium. After 3 weeks of incubation, callus treated with four different elicitors concentration (0, 2, 4, 6 mg/mL). There were significant alterations on callus culture in terms of growth, texture, color and chlorophyll content after elicitation. The results clearly demonstrated that the endophytic fungal elicitor Aspergillus sp could increase artemisinin content but did not affect the callus dry weight of A. annua. The treatment of 4 mg/mL elicitor produced the highest artemisinin content, that increased 7.6 times compared to the control, from 0.0036% to 0.0275%.
A New Unified Gas-Transport Model for Gas Flow in Nanoscale Porous Media
Authors: Chai Di , Fan Zhaoqi , Li Xiaoli 
Published: January 2019

SummaryA new unified gas-transport model has been developed to characterize single-component real-gas flow in nanoscale organic and inorganic porous media by modifying the Bravo (2007) model. More specifically, a straight capillary tube is characterized by a conceptual layered model consisting of a viscous-flow zone, a Knudsen-diffusion zone, and a surface-diffusion zone. To specify the contributions of the viscous flow and the Knudsen diffusion to the gas transport, the virtual boundary between the viscous-flow and Knudsen-diffusion zones is first determined using an analytical molecular-kinetics approach. As such, the new unified gas-transport model is derived by integrating the weighted viscous flow and Knudsen diffusion, and coupling surface diffusion. The model is also comprehensively scaled up to the bundles-of-tubes model considering the roughness, rarefaction, and real-gas effect. Nonlinear programming methods have been used to optimize the empirical parameters in the newly proposed gas-transport model. Consequently, the newly proposed gas-transport model yields the most accurate molar fluxes compared with the Bravo (2007) model and four other analytical models. One of the advantages of the new unified gas-transport model is its great flexibility, because the Knudsen number is included as an independent variable, which also endows the newly proposed model with the capability to cover the full-flow regimes. In addition, the apparent permeability has been mathematically derived from the new unified gas-transport model. A series of simulations has been implemented using methane gas. It is found through sensitivity analysis that apparent permeability is strongly dependent on pore size, porosity, and tortuosity, and weakly dependent on the surface-diffusivity coefficient and pore-surface roughness. The increased viscosity can reduce the total molar flux in the inorganic pores up to 66.0% under the typical shale-gas-reservoir conditions. The viscous-flow mechanism cannot be neglected at any pore sizes under reservoir conditions, whereas the Knudsen diffusion is found to be important when pore size is smaller than 2 nm and pressure is less than 35.0 MPa. The contribution of surface diffusion cannot be ignored when the pore size is smaller than 10 nm and the pressure is less than 15.0 MPa.
Assessing the impacts of extreme weather events on potable water quality: the value to managers of a highly participatory, integrated modelling approach
Authors: Bertone Edoardo , Sahin Oz , Richards Russell , Roiko Anne 
Published: January 2019

Abstract
A decision support tool was created to estimate the treatment efficiency of an Australian drinking water treatment system based on different combinations of extreme weather events and long-term changes. To deal with uncertainties, missing data, and nonlinear behaviours, a Bayesian network (BN) was coupled with a system dynamics (SD) model. The preliminary conceptual structures of these models were developed through stakeholders' consultation. The BN model could rank extreme events, and combinations of them, based on the severity of their impact on health-related water quality. The SD model, in turn, was used to run a long-term estimation of extreme events' impacts by including temporal factors such as increased water demand and customer feedback. The integration of the two models was performed through a combined Monte Carlo–fuzzy logic approach which allowed to take the BN's outputs as inputs for the SD model. The final product is a participatory, multidisciplinary decision support system allowing for robust, sustainable long-term water resources management under uncertain conditions for a specific location.
Caracterización del intento de suicidio en una ciudad colombiana (2012 – 2017)
Authors: Vigoya-Rubiano Andrés Ricardo , Osorio-Barajas Yury Stefany , Salamanca-Camargo Yenny 
Published: January 2019

Se trata de un estudio descriptivo cuyo objetivo fue analizar las características relacionadas con la conducta suicida de quienes fueron reportados por dicho evento en Tunja durante el periodo comprendido entre 2012 y 2017; a partir de 701 fichas de notificación de intento de suicidio del sistema nacional de vigilancia en salud pública (SIVIGILA); los resultados a partir del programa estadístico SPSS, versión 22, indican que el 51,5% se encontraban entre 16 y 25 años de edad, 53% de sexo femenino y 31% con ocupaciones agrícolas; en cuanto a características propias del intento de suicidio, se identifica mayor proporción por problemas de pareja (39,9%); el método más utilizado la intoxicación (62,4%) con al menos un diagnóstico de trastorno mental en el 37% de los casos registrados. Se concluye que los intentos de suicidio se presentaron en su mayoría en población joven, con cifras ligeramente superiores para el sexo femenino, predominio del área urbana y lugar del evento la vivienda, siendo las ocupaciones afines al campo las que presentaron mayor ocurrencia, corroborando la información obtenida a nivel nacional, con excepción al género.
Synthesis, Anticancer Evaluation and Synergistic Effects with cisplatin of Novel Palladium Complexes: DNA, BSA Interactions and Molecular Docking Study
Authors: Joksimović Nenad , Janković Nenad , Petronijević Jelena , Baskić Dejan , Popovic Suzana , Todorović Danijela , Zarić Milan , Klisurić Olivera , Vraneš Milan , Tot Aleksandar , Bugarčić Zorica 
Published: January 2019

Background:
In order to discover new agents for chemotherapy with improved properties
compared to the existing agents and bearing in mind the fact that some Pd complexes possess
better antitumor activity and exhibit less kidney toxicity compared to cisplatin, a series of novel
square-planar palladium(II) complexes [Pd (L)2] (3a-f) with O,O bidentate ligands [L = ethyl 2-
hydroxy-alkyl(aryl)-4-oxo-2-butenoate] were synthesized.

Methods:
All complexes were characterized by spectral (UV-Vis, IR, NMR, ESI-MS) and X-ray
analysis and examined for their cytotoxic effect on human cancer cell lines HeLa and MDA-MB
231 and normal fibroblasts (MRC-5). Fluorescence spectroscopic method was used for investigations
of the interactions between CT-DNA or bovine serum albumin (BSA) and complex 3c. Viscosity
measurements and molecular docking study were performed to confirm the mode of interactions
between DNA and BSA and complex 3c.

Results:
Complexes that showed the best results, 3c, 3d, and 3e, were placed under further investigations.
Selected complexes induced apoptosis and cell cycle arrest in HeLa and MDA-MB 231
cells. Low concentrations of 3c and 3e showed strong to moderate synergism with low concentrations
of cisplatin. The interaction of 3d with cisplatin was antagonistic in all used concentrations,
but low IC50 value indicates its usefulness as a single cytotoxic agent. It was also noted that the
change of viscosity is more pronounced in DNA solution after addition of complex 3c.

Conclusion:
Obtained results indicate that the novel palladium(II) complexes have the potential to
become candidates for treatment in anticancer therapy.