bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of Spectral Responses for a Ground Motion from Mediterranean Earthquake – ZEGHANGHANE Station (6.3Mw) in Morocco, and its Influence on the Structures
Authors: Ahatri Mohamed , Baba Khadija , Touijrate Soukaina , Bahi Lahcen 
Published: February 2018

The earthquakes are abrupt and sudden, and, in few seconds, they can lead to huge casualties. Nowadays, several approaches can be used to better know the seismic movement than we can expect when and where will have an earthquake. These approaches kind, always begins with a full study of the seismic action: the seismic birth, the wave formation and propagation, accelerometers and associated spectrum representation, etc.The northern region in Morocco has an important seismic activity, indeed, this region has been struck during its history by many destructive earthquakes. In this paper, we present and discuss the Mediterranean earthquake, January 25, 2016, saved in ZGH station located in Zeghanghane near of Nador city, Morocco.In this case, we determine the spectral response of the ground motion for ZGH station, and study his influence on the structures as well as make a comparison with the requirements of the Moroccan seismic construction regulations (RPS) 2000 revised in 2011.
Elemental Chemical Analysis by X-ray Fluorescence of Calcarenite Stones Used in Historical Monuments Building of Rabat (Morocco)
Authors: El Rhaffari Y. , Hraita M. , Rahmouni A. , Samaouali A. , Boukalouch M. , Geraud Y. 
Published: February 2018

A good knowledge of chemical properties, thermophysical and petrophysical parameters, makes it possible to understand the mechanisms of alteration of historical monuments, and to predict solutions limiting their evolution.
The main objective of this work is chemical analysis by X-ray fluorescence spectrometry on calcarenite stones, often used as a building material for historical monuments of Rabat (Morocco), in order to identify the nature of the rock.
The elemental chemical composition shows high concentrations of CaO and SiO2, which confirms that the main phases of the calcarenite rock studied are calcite and quartz. These are the characteristic minerals of calcareous rocks.
Mechanical behavior of the reinforced concrete frame with masonry filling Comportement mécanique des portiques en béton armé avec remplissage en maçonnerie
Authors: Kettar Jalal , Baba Khadija , Nounah Abderrahman , Bahi Lahcen 
Published: February 2018

Masonry is often used in the most of reinforced concrete structure constructions as a filling material that is important on structural characteristics. Structural contribution in the calculations was neglected or misunderstood, mainly due to the lack of a practical calculation methods and an appropriate regulatory tool.The analysis of frames filled with masonry is very complex. This complexity is linked from one part to the difference in the nature of elements and its behavior that make up the masonry itself (brick and mortar) and their interaction, and on the other part, for the large dispersion that characterizes the bricks as well as the execution's quality parameters which make it difficult to define reliable criteria for the masonry. The objective of this work is to experimentally highlight the influence of the hollow brick masonry filler, commonly used in Morocco, on reinforced concrete frames subject to lateral stresses, to deepen understanding the seismic behavior of the masonry structures by evaluating the structural performance of a specimen wall. These experimental results will be compared to those found by modeling prototypes, using SAP 2000 software, based on various approaches and models as well as other results deduced from the other researchers. The experimental study was carried out according to standard NF EN 1052-3 on two reinforced concrete frames, of dimensions (2m X 1.6m), the one with the masonry filling, and the other without filling in order to determine the initial characteristic resistance to the shearing of the masonry walls. The obtained results showed that a filling has a beneficial effect on rigidity which can be doubled compared to an empty frame. in the same way the lateral resistance. But this effect is much contrasted; it depends a lot on the characteristics essentially of the materials (bricks and concrete). This is the main reason, which justifies the divergence of the results deduced from the nine models that we used.
Assessment of the tsunami hazard on Moroccan coasts using numerical modeling
Authors: Amine Meriem , Ouadif Latifa , Baba Khadija , Bahi Lahcen 
Published: February 2018

Caused by earthquakes in the marine environment, tsunamis are often of particular violence. Pests, their damage far exceeds those caused by earthquakes earthquakes. In Morocco, seismic sensors in the national network often detect earthquakes in the marine environment. However, specialists minimize their threat given the peculiarity of the Moroccan ocean zone. The latter is characterized by the importance of the length of the faults and the depth of the seismic focus.This work can be considered as a first approach to the study and understanding tsunamis. Although Morocco has known since historical times, earthquakes and tsunamis along its coasts.This preliminary study is mainly intended to show the contribution of the numerical simulation of tsunamis, with a concrete application of the 1755 Tsunami of Lisbon based on the four source zones involving the five potentially tsunamigenic faults that are generally mentioned in the literature for this major event.
Stellenwert von Endothelin-1 beim Glaukom – ein kurzer Überblick
Authors: Gugleta Konstantin 
Published: February 2018

ZusammenfassungDieser Review-Artikel fokussiert sich auf verschiedene Aspekte der Endothelinrollen bei einem Glaukom; auf die Beteiligung von Endothelin bei anderen, vor allem vaskulären okulären Erkrankungen wird in diesem Artikel nicht im Detail eingegangen. Endothelin ist ein ubiquitäres Molekül, das in praktisch allen okulären Geweben vorhanden ist. Seine primäre physiologische Rolle ist die Steuerung des Gefäßdurchmessers und somit die Regulierung der Gewebedurchblutung. Sowohl die Sekretion als auch die Effekte des Endothelins finden lokal statt; ein Teil des Endothelins gelangt zwar in die systemische Zirkulation, jedoch ist dieser Teil variabel. Somit ist die Messung des Plasmaendothelinspiegels im venösen Blut nicht ideal für die Einschätzung der Endothelinfunktion, sowohl bei einzelnen Patienten als auch in Studienkohorten. Im Kontext der Glaukompathogenese lassen sich die wichtigsten Funktionen des Endothelins im Auge in Regulation des Augeninnendruckes, Regulation der Durchblutung und Aktivierung der Gliazellen/Astrozyten im hinteren Segment, in der Netzhaut und im Sehnerv einteilen. Bei so einem breiten Spektrum der Funktionen, die direkt bei der Pathogenese des Glaukoms involviert sind, liegt es auf der Hand, dass künftige therapeutische Ansätze beim Glaukom eine pharmakologische Modulation des Endothelins beinhalten sollten. Zu diesem Zweck ist derzeit die entsprechende Anwendung der zur Verfügung stehenden Endothelinantagonisten durch ihr ungünstiges Nebenwirkungsprofil beeinträchtigt.
Mitochondriale Dysfunktion und Bedeutung von Coenzym Q10 beim Glaukom
Authors: Erb Carl , Konieczka Katarzyna 
Published: February 2018

ZusammenfassungDie mitochondriale Funktion ist mit zahlreichen Aspekten der Gesundheit des Auges eng verknüpft. Ursächlich für mitochondriale Dysfunktionen scheint ein Ungleichgewicht zwischen der Bildung von Energie und der Menge an freien Radikalen zu sein. Dadurch kommt es neben einem Energiemangel zu einer erhöhten oxidativen Belastung der betroffenen Augengewebe mit der Folge einer Vielzahl von ophthalmologischen Beeinträchtigungen. Dabei wird zwischen primären und sekundären mitochondrialen Augenerkrankungen unterschieden. Primäre mitochondriale Erkrankungen wie bspw. die Leberʼsche hereditäre Optikusatrophie (LHON), die Retinitis pigmentosa und die chronisch progressive externe Ophthalmoplegie sind die Folge von direkten Schädigungen der mitochondrialen Funktion durch defekte Gene auf der mitochondrialen DNA (mtDNA) oder auf der nukleären DNA (nDNA). Demgegenüber sind sekundäre mitochondriale Dysfunktionen vor allem auf Umwelteinflüsse zurückzuführen. In jüngster Zeit häufen sich Hinweise darauf, dass auch mitochondriale Dysfunktionen bei vielen häufig auftretenden Augenerkrankungen wie dem Glaukom, dem „Trockenen Auge“, der diabetischen Retinopathie, der Katarakt und der altersabhängigen Makuladegeneration (AMD) eine wichtige Rolle spielen. Dieser Beitrag fasst den derzeitigen Kenntnisstand zu mitochondrialen Dysfunktionen und zur Rolle von Coenzym Q10 (CoQ10) als mögliche Therapieoption beim Glaukom zusammen.
Lexical bundles in Wikipedia articles and related texts
Authors: Hiltunen Turo 
Published: February 2018

Abstract
Wikipedia is widely used by academics and students in higher education, but research on the linguistic characteristics of this genre is scarce (Kuteeva 2016). This paper explores the usefulness of lexical bundles as an analytical tool to describe disciplinary variation within Wikipedia articles, and to contrast Wikipedia writing with two neighbouring genres, student essays and research articles. The results indicate that the occurrence of lexical bundles in Wikipedia varies between disciplines, which is in broad agreement with previous studies on other academic genres. The analysis of bundles also suggests that a credible authorial persona is less crucial to Wikipedia articles. Indicative of this is the low frequency of bundles indicating stance and engagement, which are characteristic of professional academic writing (e.g. Hyland 2008a).
I don’t want to and don’t get me wrong
Authors: Barbieri Federica 
Published: February 2018

Abstract
Blogs are one of the most prominent genres of Web 2.0; yet, research on their linguistic characteristics is limited. This study contributes to addressing this research gap by investigating lexical bundles in American blogs. Lexical bundles are units of discourse structure which can reveal a great deal about the unique linguistic characteristics and communicative functions shaping registers. Extraction of four-word bundles in a corpus of American blogs reveals, firstly, that lexical bundles are relatively uncommon in blog writing. Analyses of discourse function and grammatical patterns show that blogs rely mainly on stance expressions, which often encapsulate first person reference (e.g., I don’t want to), thus reflecting the focus on self-expression and subjectivity which characterizes this register. Like in conversation, bundles in blogs tend to be verb-phrase based. But blogs also rely substantially on referential (e.g., a lot of people) and narrative expressions (e.g., I got to see), and thus share characteristics of literate registers and fiction writing. In sum, lexical bundles in blog writing are characterized by a unique combination of features which reflect two underlying forces: mode and communicative purpose.
The benefits and risks of expressing the POT and FOT family of oligopeptide transporters in Saccharomyces cerevisiae
Authors: Kitamura Kenji , Kinsui Eldaa Zefany Banami 
Published: February 2018

Abstract
In the yeast Saccharomyces cerevisiae, all strains possess a gene for the evolutionarily conserved POT family peptide transporter, Ptr2; however, the genes for a novel FOT family transporter were found only in some wine brewing strains. The substrate specificity of the POT and FOT family of transporters was compared. Among the naturally occurring oligopeptides that were tested, Lys-Leu and Arg-Phe were Ptr2-specific substrates. Artificial dipeptide aspartame was imported specifically through the FOT transporter, but the structurally similar Asp-Phe was a substrate of both FOT and Ptr2 transporters. Furthermore, only the FOT transporter was important for high sensitivity to an antibiotic puromycin. These results demonstrate that the POT and FOT family of transporters have distinct substrate preferences although both transporters import overlapping dipeptide substrates. Having POT and FOT transporters is advantageous for cells to acquire nutrients, but also detrimental when these cells are exposed to the toxic molecules of their substrates.
A double-blind, placebo-controlled, randomised clinical study of the effect of pork collagen peptide supplementation on atherosclerosis in healthy older individuals
Authors: Igase Michiya , Kohara Katsuhiko , Okada Yoko , Ochi Masayuki , Igase Keiji , Inoue Naoki , Kutsuna Tatsuhiko , Miura Hiromasa , Ohyagi Yasumasa 
Published: February 2018

Abstract
We examined whether baPWV could be affected by pork collagen peptide (CP) ingestion. Seventy subjects were randomized into two groups (2.5 g/day CP and 2.5 g/day placebo). A significant reduction in baPWV was observed in the CP group compared to the placebo group. This study demonstrated that pork CP may contribute to the prevention of atherosclerosis in elderly.
Total variation regularization for seismic waveform inversion using an adaptive primal dual hybrid gradient method
Authors: Yong Peng , Liao Wenyuan , Huang Jianping , Li Zhenchun 
Published: February 2018

Abstract
Full waveform inversion is an effective tool for recovering the properties of the Earth from seismograms. However, it suffers from local minima caused mainly by the limited accuracy of the starting model and the lack of a low-frequency component in the seismic data. Because of the high velocity contrast between salt and sediment, the relation between the waveform and velocity perturbation is strongly nonlinear. Therefore, salt inversion can easily get trapped in the local minima. Since the velocity of salt is nearly constant, we can make the most of this characteristic with total variation regularization to mitigate the local minima. In this paper, we develop an adaptive primal dual hybrid gradient method to implement total variation regularization by projecting the solution onto a total variation norm constrained convex set, through which the total variation norm constraint is satisfied at every model iteration. The smooth background velocities are first inverted and the perturbations are gradually obtained by successively relaxing the total variation norm constraints. Numerical experiment of the projection of the BP model onto the intersection of the total variation norm and box constraints has demonstrated the accuracy and efficiency of our adaptive primal dual hybrid gradient method. A workflow is designed to recover complex salt structures in the BP 2004 model and the 2D SEG/EAGE salt model, starting from a linear gradient model without using low-frequency data below 3 Hz. The salt inversion processes demonstrate that wavefield reconstruction inversion with a total variation norm and box constraints is able to overcome local minima and inverts the complex salt velocity layer by layer.
Mathematical model of snake-type multi-directional wave generation
Authors: Muarif  , Halfiani Vera , Rusdiana Siti , Munzir Said , Ramli Marwan 
Published: February 2018

Abstract
Research on extreme wave generation is one intensive research on water wave study because the fact that the occurrence of this wave in the ocean can cause serious damage to the ships and offshore structures. One method to be used to generate the wave is self-correcting. This method controls the signal on the wavemakers in a wave tank. Some studies also consider the nonlinear wave generation in a wave tank by using numerical approach. Study on wave generation is essential in the effectiveness and efficiency of offshore structure model testing before it can be operated in the ocean. Generally, there are two types of wavemakers implemented in the hydrodynamic laboratory, piston-type and flap-type. The flap-type is preferred to conduct a testing to a ship in deep water. Single flap wavemaker has been explained in many studies yet snake-type wavemaker (has more than one flap) is still a case needed to be examined. Hence, the formulation in controlling the wavemaker need to be precisely analyzed such that the given input can generate the desired wave in the space-limited wave tank. By applying the same analogy and methodhology as the previous study, this article represents multi-directional wave generation by implementing snake-type wavemakers.
SecretSanta: flexible pipelines for functional secretome prediction
Authors: Gogleva Anna , Drost Hajk-Georg , Schornack Sebastian 
Published: February 2018

Abstract

Motivation
The secretome denotes the collection of secreted proteins exported outside of the cell. The functional roles of secreted proteins include the maintenance and remodelling of the extracellular matrix as well as signalling between host and non-host cells. These features make secretomes rich reservoirs of biomarkers for disease classification and host–pathogen interaction studies. Common biomarkers are extracellular proteins secreted via classical pathways that can be predicted from sequence by annotating the presence or absence of N-terminal signal peptides. Several heterogeneous command line tools and web-interfaces exist to identify individual motifs, signal sequences and domains that are either characteristic or strictly excluded from secreted proteins. However, a single flexible secretome-prediction workflow that combines all analytic steps is still missing.

Results
To bridge this gap the SecretSanta package implements wrapper and parser functions around established command line tools for the integrative prediction of extracellular proteins that are secreted via classical pathways. The modularity of SecretSanta enables users to create tailored pipelines and apply them across the whole tree of life to facilitate comparison of secretomes across multiple species or under various conditions.

Availability and implementation
SecretSanta is implemented in the R programming language and is released under GPL-3 license. All functions have been optimized and parallelized to allow large-scale processing of sequences. The open-source code, installation instructions and vignette with use case scenarios can be downloaded from https://github.com/gogleva/SecretSanta.

Supplementary information
Supplementary data are available at Bioinformatics online.
Foxg1 Regulates the Postnatal Development of Cortical Interneurons
Authors: Shen Wei , Ba Ru , Su Yan , Ni Yang , Chen Dongsheng , Xie Wei , Pleasure Samuel J , Zhao Chunjie 
Published: February 2018

AbstractAbnormalities in cortical interneurons are closely associated with neurological diseases. Most patients with Foxg1 syndrome experience seizures, suggesting a possible role of Foxg1 in the cortical interneuron development. Here, by conditional deletion of Foxg1, which was achieved by crossing Foxg1fl/fl with the Gad2-CreER line, we found the postnatal distributions of somatostatin-, calretinin-, and neuropeptide Y-positive interneurons in the cortex were impaired. Further investigations revealed an enhanced dendritic complexity and decreased migration capacity of Foxg1-deficient interneurons, accompanied by remarkable downregulation of Dlx1 and CXCR4. Overexpression of Dlx1 or knock down its downstream Pak3 rescued the differentiation detects, demonstrated that Foxg1 functioned upstream of Dlx1-Pak3 signal pathway to regulate the postnatal development of cortical interneurons. Due to the imbalanced neural circuit, Foxg1 mutants showed increased seizure susceptibility. These findings will improve our understanding of the postnatal development of interneurons and help to elucidate the mechanisms underlying seizure in patients carrying Foxg1 mutations.
Development and Psychometric Validation of a Questionnaire Assessing the Impact of Memory Changes in Older Adults
Authors: Shaikh Komal T , Tatham Erica L , Parikh Preeyam K , McCreath Graham A , Rich Jill B , Troyer Angela K 
Published: February 2018

Abstract

Background and Objectives
Many healthy older adults experience age-related memory changes that can impact their day-to-day functioning. Qualitative interviews have been useful in gaining insight into the experience of older adults who are facing memory difficulties. To enhance this insight, there is a need for a reliable and valid measure that quantifies the impact of normal memory changes on daily living. The primary objective of this study was to develop and validate a new instrument, the Memory Impact Questionnaire (MIQ).

Research Design and Methods
We examined the underlying component structure and psychometric properties of the MIQ in a sample of 205 community-dwelling older adults.

Results
Principal component analysis revealed three clusters: (a) Lifestyle Restrictions, (b) Positive Coping, and (c) Negative Emotion. Comparisons of the corresponding subscale scores with scores on other instruments revealed good convergent and discriminant validity. In addition, the MIQ subscales and the total score showed good test–retest reliability (rs = 0.65–0.91) and internal consistency (αs = 0.87–0.93).

Discussion and Implications
This novel questionnaire can be used in both clinical and research settings to better understand the impact of memory changes on the day-to-day functioning of older adults and to monitor outcomes of support programs for this population.
Giant Extra-Axial Cavernous Angioma of the Falx: Case Report
Authors: Simonin Alexandre , Passaplan Caroline , Sancho Sara , Rusconi Angelo , Otten Philippe 
Published: February 2018

Abstract

BACKGROUND AND IMPORTANCE
Cavernous angiomas or cavernomas are vascular malformations usually located in the brain parenchyma. However, they rarely present as extra-axial lesions, attached to the dura, and may mimic meningiomas. Most reported cases concern the cavernous sinus region and other locations are very uncommon.

CLINICAL PRESENTATION
A 61-yr-old female known for long-standing mental illness presented with progressive gait instability. Imaging studies revealed an extra-axial lesion in relation to the anterior part of the falx cerebri. An interhemispheric approach was used to remove the lesion. Pathological analysis revealed features compatible with an extra-axial cavernoma: structureless vascular channels lacking smooth muscle and elastic lamellae, without intervening brain parenchyma.

CONCLUSION
Cavernous angiomas or cavernomas can present as extra-axial lesions. Although progressive growth can be observed, they should not be considered as tumoral lesions, because there is no cellular duplication. Unlike other locations, resection of anterior cranial fossa extra-axial cavernomas seems to be facilitated by minimal bleeding.
Gender and Rural Livelihoods: Agricultural Commercialization and Farm/Non-Farm Diversification
Authors: Djurfeldt Agnes Andersson 
Published: February 2018

Abstract
This chapter examines possible discrimination against female farm managers with respect to prices or market segmentation. Patterns of commercialization are fluid. Particular countries stand out with respect to certain crops, however: for maize, a growing bias against female farm managers can be noted in Zambia. Mozambique, Malawi, and to a lesser extent Tanzania stand out in terms of non-grain food crops, where market participation by male farm managers had increased relative to female-headed households. Poorer commercial possibilities are tied strongly to production factors, where lack of labour and land prevent the generation of a marketable surplus. An important distinction is that between women who manage their own farms and women who live in households headed by men: for the former the lack of access to agrarian resources prevents generation of a marketable surplus for the latter the outcomes from sales are controlled by their husbands.