bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcumin as an Adjunct Therapy and microRNA Modulator in Breast Cancer
Authors: Norouzi Saeed , Majeed Muhammed , Pirro Matteo , Generali Daniele , Sahebkar Amirhossein 
Published: April 2018

Background:
Pathogenesis of breast cancer is paralleled by distinct alterations in the expression profile
of several microRNAs (miRNAs). Recent studies have shown that miRNAs can serve as diagnostic and prognostic
markers, and also as therapeutic targets in breast cancer. Curcumin is a biologically active dietary polyphenol
that has emerged with strong anti-tumor properties that are also documented in breast cancer.

Methods:
A multi-database electronic search was performed to provide an overview of curcumin as an adjunct
therapy and miRNA modulator in breast cancer and highlight the significance of observations for the treatment of
cancer therapies.

Results:
The putative anti-tumor properties of curcumin are mediated by diverse mechanisms including inhibition
of cell proliferation, metastasis, migration, invasion and angiogenesis, and induction of G2/M cell cycle arrest,
apoptosis and paraptosis. Recent evidence implies that curcumin can interact with several oncogenic and tumorsuppressive
miRNAs involved in different stages of breast cancer. In this context, up-regulation of miR181b,
miR-34a, miR-16, miR-15a and miR-146b-5p, and down-regulation of miR-19a and miR-19b have been shown
following the treatment of several breast cancer cell lines with curcumin. These effects lead to the suppression of
tumorigenesis and metastasis, and induction of apoptosis.

Conclusion:
Curcumin appears as an important miRNA modulator in breast cancer. However, further investigations
are warranted to elucidate the impact of curcumin on miRNA transcriptome profile of breast cancer and the
resulting impact of experimental models.
A Very Rare Cause of Lower Limb Ischemia in Young People: Popliteal Artery Entrapment
Authors: Altinsoy Hasan Baki , Alatas Ozkan , Khalil Emjed , Kara Kenan Abdurrahman , Okten Candan Cudi , Dogan Omer Faruk 
Published: April 2018

Background:
Popliteal artery entrapment syndrome (PAES) is a very rare pathology that can cause lower extremity ischemia in healthy young people. Anomalous anatomic relationships between the popliteal artery (PA) and the surrounding musculo-tendinous structures cause PAES. We present 31 patients with PAES in 35 limbs that were treated surgically in our clinic within a 12-year period.

Patients and Methods:
From 2001 to 2015, 31 patients (mean age: 32 ± 7.4 years) underwent surgery for PAES. ; 4 patients presented had bilateral PAES. Doppler ultrasonography (US), magnetic resonance angiography (MRA), and conventional angiography were performed as diagnostic procedures. We detected Type I PAES in 4 limbs and Type II PAES in 12 limbs. In the remaining 19 limbs, we diagnosed Type III or Type IV PAES. Simple release of the PA, PA embolectomy and simple release, and the radial artery (RA) patch angioplasty, with or without thromboendarterectomy (TEA), were performed. In 12 limbs, PA continuity was provided by RA interposition.

Results:
With the exception of 5 patients, no complications were seen after surgery. Haematoma was detected in 2 patients and local infection in 2 patients. One patient required a revision for recurrent PA thromboembolic event 12 h after surgery. At a median follow- up of 23 months (range: 11-29 months), there were no postoperative complications.

Conclusions:
PAES can result in lower limb ischemia due to chronic vascular trauma in young healthy patients. The use of diagnostic tools such as US, a non-invasive method, and MRA are effective diagnostic tools for early diagnosis. With their combined approach, exact and early diagnosis can be achieved. PA release, alone or with arterial bypass using RA, is a viable treatment option when intervention is necessary to prevent limb loss in the early stages of the disease.
Pengaruh Adaptasi Waktu Administrasi yang disebabkan Penggunaan Lembar Jawaban Komputer terhadap Hasil CFIT 3 A dan 3 B
Authors: Saptoto Ridwan 
Published: April 2018

Previous research showed difference in intelligence level caused by difference in answering method. This research aimed to adapt test time administered using computer answer sheet. Adaptation time was conducted by comparing time needed to give answer by making cross line and blackening answer dots using 2B computer pencil. Experiment method with two independent group design had chosen. Data analysis showed no difference in raw score between control group and experiment group in CFIT 3A (t = 1.045, p > 0.05), CFIT 3B (t = 0.368, p > 0.05), and CFIT 3A and 3B (t = 0.791, p > 0.05). Data analysis also found no difference in intelligence level between both groups in CFIT 3A (t = 1.063, p > 0.05), CFIT 3B (t = 0.470, p > 0.05), and CFIT 3A and 3B (t = 0.771, p > 0.05). Adaptation administration time did not change intelligence test results. Abstrak.Hasil penelitian sebelumnya menunjukkan adanya perbedaan tingkat inteligensi yang disebabkan oleh perbedaan metode memberikan jawaban. Penelitian ini bertujuan melakukan adaptasi terhadap tes yang menggunakan lembar jawaban komputer. Adaptasi waktu dilakukan dengan membandingkan waktu yang dibutuhkan untuk memberikan jawaban dengan cara menyilang dan menghitamkan alternatif jawaban menggunakan pensil 2B. Metode eksperimen dengan desain dua kelompok independen dipilih dalam penelitian ini. Analisis data menunjukkan tidak terdapat perbedaan skor mentah antara kelompok kontrol dan kelompok eksperimen pada CFIT 3A (t = 1,045, p > 0,05), CFIT 3B (t = 0,368, p > 0,05), serta CFIT 3A dan 3B (t = 0,791, p > 0,05). Analisis data juga menemukan tidak terdapat perbedaan tingkat inteligensi antara kedua kelompok pada CFIT 3A (t = 1,063, p > 0,05), CFIT 3B (t = 0,470, p > 0,05), serta CFIT 3A dan 3B (t = 0,771, p > 0,05). Adaptasi waktu administrasi tidak mengubah hasil tes inteligensi.
RESPON PRIMIPARA SAAT DIPUTUSKAN SECTIO CAESAREA DARURAT
Authors: Sari Febria Syafyu 
Published: April 2018

<p>Primipara yang akan menjalani persalinan secara Sectio Caesarea (SC) dapat mempengaruhi kesiapan praoperatif saat diputuskan SC. Ketidaksiapan primipara dalam menghadapi praoperatif SC dapat meningkatkan resiko depresi postpartum. Penelitian kualitatif dengan pendekatan desain fenomenologi deskriptif yang bertujuan untuk mengeksplorasi respon pertama kali primipara pada praoperatif SC. Penelitian ini dilaksanakan pada tahun 2016 di ruang Kebidanan, dengan jumlah partisipan sebanyak enam orang yaitu enam pasien SC darurat. Hasil penelitian ini dianalisis menggunakan metode Collaizi. Etika yang diperhatikan dalam penelitian ini dengan menghormati prinsip<em> </em>etik penelitian dan keabsahan data memperhatikan kriteria: <em>credibility, transferability, dependability </em>dan<em> confirmability</em>. Didapatkan hasil penelitian yaitu respon fisik dan psikologis. Hasil penelitian ini dapat disimpulkan bahwa hampir keseluruhan partisipan mengalami kecemasan. Partisipan berusaha mendekatkan diri pada Tuhan, berdoa dan berserah diri sehingga tidak terbentuk koping yang mal adaptif. Saran untuk petugas kesehatan dapat melakukan asuhan keperawatan psikososial sehingga dapat menanamkan kepercayaan kepada ibu yang akan melakukan persalinan SC dan dapat menurunkan kecemasan</p><p> </p><p>Primiparas who will undergo cesarean delivery by Caesarea (CS) may affect preoperative preparedness when the CS is decided. Primiparous unpreparedness in the face of preoperative CS may increase the risk of postpartum depression. Qualitative research with descriptive phenomenology design approach aimed to explore primitive experience on CS preoperative. The study was conducted in January - July 2016 in Midwifery room, with six participants, six emergency CS patients. The results of this study were analyzed using the Collaizi method. Ethics is considered in this study with respect to the principles of research ethics and data validity pay attention to the criteria: credibility, transferability, dependability and confirmability. The result of this research is perception to CS. The results of this study can be concluded that participants perceive CS which is a frightening invasive action that will endanger the safety of mother and fetus .. Suggestions for mothers can be the next learning in the face of labor by looking at experience in facing preoperative emergency CS</p>
Karakterisasi Antosianin Buah Murbei Spesies Morus alba dan Morus cathayana di Indonesia
Authors: Sitepu Rehmadanta , Heryanto Heryanto , Brotosudarmo Tatas H.P. , Limantara Leenawaty 
Published: April 2018

Buah murbei kaya antioksidan karena kandungan antosianin yang banyak. Sayangnya, pemanfaatannya sebagai sumber antioksidan di Indonesia masih minim. Pemanfaatan tanaman murbei hanya sebatas daun yang dijadikan pakan ternak dan teh. Penelitian ini bertujuan untuk melakukan karakterisasi antosianin buah murbei spesies Morus alba dan Morus cathayana. Karakterisasi antosianin ekstrak buah murbei Morus cathayana dan Morus alba dilakukan menggunakan pelarut 0,1% asam klorida (HCl) dalam metanol dan dianalisis menggunakan spektrofotometer UV-tampak dan Kromatografi Cair Kinerja Tinggi (KCKT). Hasil serapan spektra UV-tampak yang diperoleh dari ekstrak kasar menunjukkan spektra serapan ekstrak buah M. cathayana memberikan nilai yang lebih tinggi ± 1,3 a.u dibandingkan serapan yang diperoleh dari ekstrak kasar buah M. alba dengan serapan ± 0,4 a.u. Nilai total antosianin yang diperoleh dari M. cathayana sebanding dengan serapan ekstrak segarnya, yaitu 40,39 ± 7,64 mg/g berat kering dibandingkan M. alba yang memiliki nilai total antosianin 11,57 ± 3,02 mg/g berat kering. Hasil kromatogram dari KCKT menggunakan kolom XR-ODS dengan pengelusi A adalah 0,1% asam formiat dalam asetonitril dan pengelusi B adalah 0,1% asam formiat dalam air menunjukkan baik M. cathayana maupun M. alba memiliki dua pigmen antosianin dominan. Walaupun bergitu, intensitas kromatogram M. cathayana lebih tinggi dibandingkan intesitas pada M. alba. Nilai intensitas M. cathayana adalah 50 mAU untuk waktu tambat 7,86 menit dan 15 mAU untuk waktu tambat 8,38 menit. Nilai intensitas M. alba adalah 10 mAU untuk waktu tambat 7,35 menit dan 3 mAU untuk waktu tambat 7,76 menit. Dua antosianin dominan pada M. alba dan M. cathayana diprediksi merupakan sianidin-3-O-glukosida dan sianidin-3-O-rutinosida.
Quiver dari Aljabar Lintasan Terhubung
Authors: Kurniawan Vika Yugi 
Published: April 2018

Graf berarah dapat dipandang sebagai pasangan 4-tupel yang terdiri dari dua himpunan serta dua pemetaan dan disebut sebagai quiver . Untuk sebarang quiver dan lapangan , dapat didefinisikan suatu -aljabar yang disebut dengan aljabar lintasan yang memiliki basis berupa himpunan semua lintasan yang ada pada quiver . Pada makalah ini, dipelajari sifat-sifat dari suatu aljabar lintasan atas lapangan . Selanjutnya sifat-sifat tersebut digunakan untuk menunjukkan keterkaitan antara aljabar lintasan terhubung dengan quivernya. Diakhir pembahasan ditunjukan bahwa suatu aljabar lintasan dari suatu quiver merupakan aljabar terhubung jika dan hanya jika merupakan quiver terhubung
Kesesuaian Pelaksanaan Standar Pelayanan Minimal (SPM) Bidang Farmasi Di Instalasi Farmasi Rumah Sakit Undata Palu
Authors: Faradillah Nurul , Mukaddas Alwiyah , Diana Khusnul 
Published: April 2018

This study aims to determine the suitability of the implementation of the Pharmacy Minimum Service Standards in the hospital at pharmacy section that includes: the length of service waiting time of compounded and available drugs, no error incident of drug administration and prescribing in refer to the formulation at the pharmacy installation, outpatient unit, in Undata Hospital, Palu. This study is a descriptive with quantitative data retrieval. Samples were prescription entered at the Undata hospital in the period from February to May 2016 including 12 sheets of cash prescription, 10 sheets of cash compounded prescription, 188 sheets of guarantee prescription and 187 sheets of guarantee compounded prescription. The results showed that the average length of services waiting time of cash prescriptions was 06 minutes 12 seconds, guarantee prescriptions was 07 minutes 01 seconds, cash compounded prescriptions was 17 minutes 02 seconds, guarantee compounded prescriptions was 16 minutes 05, no error incidence of drug administration was 100% and prescribing in refer to the formularium was 66.2%. These were in accordance to the standard of Kepmenkes RI No. 129 year 2008, except for prescribing in refer to the formularium. Therefore, it is suggested for drugs order should follow the hospital formularium
Pemodelan Reservoir Panasbumi Menggunakan Data Magnetik di Desa Toro Kecamatan Kulawi
Authors: Baligau Chris Indra Cahya , Kasim Sandra , Efendi Rustan 
Published: April 2018

Penelitian magnetik telah dilakukan di lokasi manifestasi panasbumi Desa Toro Kecamatan Kulawi Kabupaten Sigi. Tujuan penelitian untuk memodelkan struktur batuan penyusun reservoir panasbumi dan mengestimasi kedalaman reservoir panasbumi. menggunakan data magnetik yang diperoleh di lapangan. Data magnetik yang diperoleh selanjutnya diolah dengan tahapan melakukan beberapa koreksi yaitu koreksi IGRF dan koreksi vairiasi harian guna memperoleh data anomali medan magnet total. Pemodelan kedepan (Forward Modeling) dan Pemodelan kebelakang (Inverse Modeling) digunakan untuk mengetahui batuan penyusun reservoir panasbumi dan kedalamannya. Hasil pemodelan diperoleh bahwa batuan penyusun reservoir berupa batuan yang tersusun atas mineral non magnetik dengan nilai suseptibilitas yaitu: -0,00030125 SI, -0,003413 SI, -0,0084446, SI, -0,05824451 SI dan -0,066777 SI. Reservoir panasbumi berada pada kedalaman 2000-3000 m di bawah permukaan
Pemurnian dan Karakterisasi Silika Menggunakan Metode Purifikasi (Leaching) dengan Variasi Waktu Milling pada Pasir Kuarsa Desa Pasir Putih Kecamatan Pamona Selatan Kabupaten Poso
Authors: Darwis Darmawati , Khaeroni Rany , Iqbal Iqbal 
Published: April 2018

Penelitian tentang pemurnian dan karakterisasi silika pada pasir kuarsa Desa Pasir Putih Kecamatan Pamona Selatan Kabupaten Poso telah dilakukan. Penelitian ini bertujuan untuk memperoleh kadar kemurnian silika (SiO2) yang tinggi menggunakan metode purifikasi (leaching) dengan variasi waktu milling selama 2-5 jam. Sebelum pemurnian, pasir kuarsa dihaluskan dengan menggunakan ball milling. Selanjutnya direndam dalam larutan HCl 2 M selama 12 jam lalu dibersihkan dengan aquades hingga pH netral. Sesudah itu, setiap sampel dikarakterisasi menggunakan alat XRF dan XRD. Dari hasil karakterisasi XRF diperoleh kadar kemurnian silika tertinggi terdapat pada sampel dengan waktu milling 5 jam (99,90%). Kemudian hasil karakterisasi XRD pada sampel tersebut memiliki struktur kristal dengan sistem kristal hexagonal, yang meliputi jarak bidang difraksi, konstanta kisi, dan derajat kristalin ketika dicocokkan dengan software Search Match dan data JCPDS ialah berturut- turut 3,35 Ǻ, a = b = d = 4,90 Ǻ, c = 5,44 Ǻ, dan 80,11%.
Identifikasi Lapisan Lapuk Bawah Permukaan Menggunakan Seismik Refraksi di Desa Lengkeka Kecamatan Lore Barat Kabupaten Poso
Authors: Artono Vicho Yugho , Efendi Rustan , Sandra Sandra 
Published: April 2018

Penelitian tentang identifikasi lapisan lapuk bawah permukaan menggunakan seismik refraksi telah dilakukan di Desa Lengkeka Kecamatan Lore Barat Kabupaten Poso. Tujuan penelitian ini adalah untuk mengetahui respon kecepatan gelombang seismik refraksi pada lapisan bawah permukaan dan ketebalan lapisan lapuk dengan menggunakan metode waktu tunda yang merupakan bagian dari metode seismik refraksi. Penelitian ini dilakukan pada 4 lintasan yang berbeda dengan menggunakan 24 buah geophone pada setiap lintasan. Pada lintasan 1,2,3 dan 4 diperoleh kecepatan rata-rata perambatan gelombang secara berturut-turut 1.177 - 2.388 m/s, 690 - 890 m/s, 1.550 - 2.220 m/s dan 1.396 - 2.075 m/s. Penentuan struktur batuan diklasifikasikan dengan kecepatan gelombang P pada berbagai batuan sedimen serta melihat kondisi geologi wilayah penelitian. Struktur lapisan bawah permukaanpada setiap lintasan memiliki 3 batuan penyusun, dimana lapisan pada bawah permukaannya didominasi oleh batuan alluvium, pasir tersaturasi, tanah liat, lapuk berlapis atau sedimen yang tidak terkonsolidasi, dan kerikil tersaturasi. Berdasarkan jenis lapisan batuan tersebut, maka daerah ini diduga mengalami pelapukan pada bawah permukannya.
Postoperative Death After Lower-Limb Amputation in a National Prevalent Cohort of Patients With Diabetes
Authors: Gurney Jason K. , Stanley James , Rumball-Smith Juliet , York Steve , Sarfati Diana 
Published: April 2018

OBJECTIVE
The objectives of this study were to 1) describe postoperative mortality after lower-limb amputation in a national prevalent cohort of patients with diabetes, and 2) investigate whether postoperative mortality differs by demographic subgroup, patient morbidity level, and health system factors related to the facility in which the amputation occurred.

RESEARCH DESIGN AND METHODS
A national prevalent cohort of 302,339 individuals diagnosed with diabetes between 2005 and 2014 was followed until the end of 2014 for major and minor lower-limb amputation and subsequent postoperative mortality by using national health data collections. Kaplan-Meier survival analysis was used to determine postoperative survival, whereas Cox proportional hazards models were used to describe the relative hazard of postoperative mortality, adjusted for covariates.

RESULTS
A total of 6,352 lower-limb amputations occurred over the study period (2,570 major amputations, 3,782 minor amputations). More than 11% of patients who underwent major amputation died within 30 days, whereas nearly 18% died within 90 days. Death was most common among older patients and indigenous Māori. Sex, deprivation, rurality, hospital volume, admission type, and patient comorbidity were not consistently or substantially independently associated with risk of postoperative mortality.

CONCLUSIONS
In a national prevalent cohort of patients with diabetes, there was high risk of postoperative mortality as well as a differential risk of postoperative mortality by demographic subgroup. Further work is required to investigate the drivers of postoperative mortality among patients with diabetes who undergo amputation.
Las derivaciones de la identidad absoluta
Authors: Laera Rodrigo 
Published: April 2018

Resumen: El presente trabajo tiene como fin discernir entre tres tipos de identidad en el marco de la ontología formal: la absoluta, la simple y la identitaria. A partir de estas distinciones se propone la subsistencia de un panteísmo de la identidad que es entendido como un simple presentarse sin nada que se presente. Palabras claves: identidad, ontología formal, diferencia, presentación Abstract: This paper aims to distinguish between three types of identity within the framework of formal ontology: absolute, simple and identitary. As a result of aid differences, the subsistence of a pantheism of identity is upheld as simply presenting itself with nothing being presented. Keywords: identity, formal ontology, difference, presentation.
EL NUBARRÓN EPISTEMOLÓGICO DE LA METAMORFOSIS DEL YO, ... Y LA POSIBILIDAD DE UN NOSOTROS.
Authors: Colman Rucco Aldana Sabria 
Published: April 2018

Resumen El tema del presente ensayo es el análisis de la confusión epistemológica de la metamorfosis del concepto de "yo" en la historia. Advierte el peligroso cambio de autoconciencia que ha tenido nuestra especie, de qué forma el ego de la especie humana trabaja silenciosamente, y cómo está bajo amenaza una concepción del "nosotros" lejos de todo individualismo y especismo. Se destaca la importancia de reinventar la noción del "nosotros" por parte del ser humano, para vernos como un conjunto armónico.Palabras clave: metamorfosis del yo, autoconciencia, ecologism, nosotros. Abstract The theme of the present essay is the analysis of the epistemological vagueness of the concept of 'I' due to the metamorphosis this notion has suffered throughout history. It analyzes the dangerous change of self-conciousness that has had our species, in what way human ego works silently, and how our conception of 'us' is under threat, far from all individualism and speciesism. It underlines the human need and importance of rebuiding the notion of 'us', in order to see ourselves as a harmonious whole.Key words: metamorphosis of 'I', self-awareness, ecologism, us.
Numerical Modelling of Metal-Elastomer Spring Nonlinear Response for Low-Rate Deformations
Authors: Sikora Wojciech , Michalczyk Krzysztof , Machniewicz Tomasz 
Published: April 2018

Abstract
Advanced knowledge of mechanical characteristics of metal-elastomer springs is useful in their design process and selection. It can also be used in simulating dynamics of machine where such elements are utilized. Therefore this paper presents a procedure for preparing and executing FEM modelling of a single metal-elastomer spring, also called Neidhart’s spring, for low-rate deformations. Elastomer elements were made of SBR rubber of two hardness values: 50°Sh and 70°Sh. For the description of material behaviour the Bergström-Boyce model has been used.
Invariant, Decoupling and Blocking Zeros of Fractional Linear Systems
Authors: Kaczorek Tadeusz 
Published: April 2018

Abstract
The notions of invariant, decoupling and blocking zeros are extended to the fractional linear systems. It is shown that: 1) The zeros are closely connected with the controllability and observability of the linear systems and their transfer functions matrices. 2) The state vector of the fractional system for any input and zero initial conditions is independent of the input decoupling zeros of the system. 3) The output of the fractional system for any input and zero initial conditions is independent of the input-output decoupling zeros of the system.
Constructional Features of Ropes in Functional Units of Mining Shaft Hoist
Authors: Mańka Eugeniusz , Słomion Małgorzata , Matuszewski Maciej 
Published: April 2018

Abstract
In this paper structural analysis of steel ropes applied in mining shaft hoists was conducted. Functions of the ropes which they fulfilled in these shaft hoists were identified. Expected operational features of ropes were indicated too. An analysis was carried out four identified groups of ropes: hoisting ropes, balance ropes, leading rope and fender ropes. Basic constructional features: geometrical and material of ropes, which they should be characterized in each of mentioned functional groups were indicated. Constructional structures of mentioned steel ropes, the most often applied in domestic mining shaft hoists were described. Observed tendencies in analyzed issues also were shown.
Differentiation and Typology of the Moravian Countryside
Authors: Stonawská Kateřina , Vaishar Antonín 
Published: April 2018

Abstract
The authors argue that differentiation of various types of countryside is more important than to look for the definition of the rural against the urban. The paper is aimed at a typology of the Moravian countryside. Based on multifunctional (both hard and soft) data, Moravian micro-regions were divided into four categories – progressive, deficit and suburban countryside and predominantly urban micro-regions. Each of the categories has its own characteristics, threats, and needs. The authors stress that the approach of regional politics and both European and national subsidies have to take into account different categories of rural micro-regions. However, particular decisions have to be made in the intersection of the lowest regional level and the bottom-up approach expressed by community lead local development.