bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of Compressed Natural Gas Pressure Vessel (Type II) to Improve Storage Efficiency and Structural Reliability
Authors: Kwak Hyo Seo , Park Gun Young , Kim Chul 
Published: October 2019

Abstract
Type II storage vessel, which consists of a metallic liner hoop wrapped with a carbon fiber-resin composite to work at high pressure, has been widely adopted as the fuel container for compressed natural gas (CNG) vehicles. The general vessel, manufactured by welding enclosures to an open-end cylinder, shows uniform thickness throughout the whole liner, while the high pressure vessel, fabricated by the deep drawing and ironing (D.D.I) and spinning processes, has the integral junction part of cylinder with increased end thickness along the meridian direction. This study established a design method for improvement of failure resistance and inner capacity of the seamless CNG pressure vessel (Type II) through finite element analysis with consideration of thickness variation. Autofrettage pressure is used to enhance fracture performance and fatigue life of the vessel, and variations of stress behaviors in the liner and composite were analyzed during the autofrettage process. The influence of the composite on generation of compressive residual stress was investigated. In order to verify advantages of the D. D. I. and the spinning processes for structural safety at the end closure, the stress distribution considering thickness variation was compared with that with uniform thickness, and the maximum inner capacity objective satisfying structural reliability was obtained. The inner capacity of the proposed model with the ratio of major axis to minor axis, 2.2, was expanded by 4.5. Theoretical equivalent stresses were compared with those from the simulations, and the technique of FEM was verified.
A Lumped-Mass Model for Large Deformation Continuum Surfaces Actuated by Continuum Robotic Arms
Authors: Habibi Hossein , Yang Chenghao , Godage Isuru S. , Kang Rongjie , Walker Ian D. , Branson David T. 
Published: October 2019

AbstractCurrently, flexible surfaces enabled to be actuated by robotic arms are experiencing high interest and demand for robotic applications in various areas such as healthcare, automotive, aerospace, and manufacturing. However, their design and control thus far has largely been based on “trial and error” methods requiring multiple trials and/or high levels of user specialization. Robust methods to realize flexible surfaces with the ability to deform into large curvatures therefore require a reliable, validated model that takes into account many physical and mechanical properties including elasticity, material characteristics, gravity, external forces, and thickness shear effects. The derivation of such a model would then enable the further development of predictive-based control methods for flexible robotic surfaces. This paper presents a lumped-mass model for flexible surfaces undergoing large deformation due to actuation by continuum robotic arms. The resulting model includes mechanical and physical properties for both the surface and actuation elements to predict deformation in multiple curvature directions and actuation configurations. The model is validated against an experimental system where measured displacements between the experimental and modeling results showed considerable agreement with a mean error magnitude of about 1% of the length of the surface at the final deformed shapes.
Foldable Hexagonal Structures Based on the Threefold-Symmetric Bricard Linkage
Authors: Yang Fufu , You Zhong , Chen Yan 
Published: October 2019

AbstractThe threefold-symmetric Bricard linkage, a special type of Bricard linkage, is able to generate spatial motion in 3D space with well-defined threefold rotational symmetries and three symmetric planes, which makes it a robust base linkage in designing many one-degrees-of-freedom (DOF) foldable structures. However, its practical applications are limited, as the design method with the consideration of the actual assembly is still an ambiguous area. In this paper, a foldable hexagonal structure based on the alternative form of the threefold-symmetric Bricard linkage is designed and manufactured. Geometric conditions for achieving the desired deployment are analyzed at first. Then the relationship among kinematic variables of the linkage and the geometric parameters of physical bars with a regular triangular cross-section are set up. Finally, an intuitive approach is presented to detect two types of physical blockages in the motion paths of deployment. The proposed method supplies a convenient way to design foldable hexagonal structures for potential practical applications.
Simulation of Brain Response to Noncontact Impacts Using Coupled Eulerian–Lagrangian Method
Authors: Na Miao , Beavers Timothy J. , Chandra Abhijit , Bentil Sarah A. 
Published: October 2019

Abstract
Finite element (FE) method has been widely used for gaining insights into the mechanical response of brain tissue during impacts. In this study, a coupled Eulerian−Lagrangian (CEL) formulation is implemented in impact simulations of a head system to overcome the mesh distortion difficulties due to large deformation in the cerebrospinal fluid (CSF) region and provide a biofidelic model of the interaction between the brain and skull. The head system used in our FE model is constructed from the transverse section of the human brain, with CSF modeled by Eulerian elements. Spring connectors are applied to represent the pia-arachnoid connection between the brain and skull. Validations of the CEL formulation and the FE model are performed using the experimental results. The dynamic response of brain tissue under noncontact impacts and the brain regions susceptible to injury are evaluated based on the intracranial pressure (ICP), maximum principal strain (MPS), and von Mises stress. While tracking the critical MPS location on the brain, higher likelihood of contrecoup injury than coup injury is found when sudden brain−skull motion takes place. The accumulation effect of CSF in the ventricle system, under large relative brain−skull motion, is also identified. The FE results show that adding relative angular velocities, to the translational impact model, not only causes a diffuse high strain area, but also cause the temporal lobes to be susceptible to cerebral contusions since the protecting CSF is prone to be squeezed away at the temporal sites due to the head rotations.
Wire Vibration Modeling and Experimental Analysis for Wire Saw Machining
Authors: Tang Aofei , Li Shujuan , Yang Guigeng , Li Lun , Landers Robert G. 
Published: October 2019

Abstract
Surface roughness is the key index point of wire saw processing silicon carbide (SiC). Many factors influence wafer surface quality, which is determined by the motion of the wire relative to the part. The vibration characteristic of wire saw and the process parameters are concerned factors in this paper, which presents a wire vibration model to study the wire saw vibration law. Experimental studies of a stationary wire are conducted to calibrate the damping coefficient and experimental studies of a moving wire are used to validate the developed model. Simulation, theoretical, and experimental data for wire vibrations during a variety of machining processes are found to compare very well, and the effects of various wire saw process parameters are investigated to analyze the influences of process parameters on wire vibration. It was shown that increasing the wire tension and feed rate, or decreeing the wire length, decreases the wire's first dominant frequency, and that changes in the wire velocity had a negligible effect. Finally, the measurement of the surface morphology and wire saw vibrations for different processing parameters was conducted, and it was seen that increases in the wire velocity and wire tension increases part surface quality and decreases processing time, while an increase in the feed rate decreases both part surface quality and processing time. The results show a clear correlation between the amplitude of the wire vibration outside of the processing zone and the part surface quality.
The NoHoW protocol: a multicentre 2×2 factorial randomised controlled trial investigating an evidence-based digital toolkit for weight loss maintenance in European adults
Authors: Scott Sarah Ellen , Duarte Cristiana , Encantado Jorge , Evans Elizabeth H , Harjumaa Marja , Heitmann Berit Lilienthal , Horgan Graham W , Larsen Sofus C , Marques Marta Moreira , Mattila Elina , Matos Marcela , Mikkelsen Marie-Louise , Palmeira António L , Pearson Beth , Ramsey Lauren , Sainsbury Kirby , Santos Inês , Sniehotta Falko , Stalker Carol , Teixeira PJ , Stubbs R. James 
Published: October 2019

IntroductionObesity and associated diseases place a severe burden on healthcare systems. Behavioural interventions for weight loss (WL) are successful in the short term but often result in weight regain over time. Self-regulation of eating and activity behaviours may significantly enhance weight loss maintenance (WLM) and may be effectively augmented by contextual behavioural approaches to emotion regulation. The NoHoW trial tests the efficacy of a theoretically informed, evidence-based digital toolkit using a mobile-enabled website, activity trackers and Wi-Fi scales for WLM aiming to target (1) self-regulation and motivation, and (2) emotion regulation in adults who achieved clinically significant (≥5%) WL in the previous 12 months (initial body mass index (BMI) ≥25 kg/m2).Methods and analysisThe study is an 18-month, 3-centre, 2×2 factorial single-blind, randomised controlled trial, which recruited 1627 participants achieving ≥5% WL between March 2017 and March 2018. Participants are randomly allocated to one of four arms: (1) self-monitoring only (self-weighing and activity tracker), (2) self-regulation and motivation, (3) emotion regulation or (4) combined self-regulation, motivation and emotion regulation. Participants attend four clinical investigation days at 0, 6, 12 and 18 months and are instructed to use the digital toolkit for 18 weeks during the first 6 months and at their discretion for the remaining 12 months. The primary outcome is change in weight (kg) at 12 months from baseline. Secondary outcomes are body composition (eg, bioimpedance analysis), health biomarkers (glycated haemoglobin, lipids, blood pressure, hair cortisol), dietary intake, physical activity, sleep, motivational, self-regulatory, emotion regulatory moderators/mediators of WLM, engagement, user experience, acceptability and cost-effectiveness of the interventions.Ethics and disseminationEthical approval was granted by Institutional Ethics Committees at the Universities of Leeds (17–0082; 27 February 2017), Lisbon (17/2016; 20 February 2017) and Capital Region of Denmark (H-16030495, 8 March 2017). Results will be published in scientific journals.Trial registration numberISRCTN88405328.
Disease burden and cost of hidradenitis suppurativa: a retrospective examination of US administrative claims data
Authors: Marvel Jessica , Vlahiotis Anna , Sainski-Nguyen Amy , Willson Tina , Kimball Alexandra 
Published: October 2019

ObjectivesHidradenitis suppurativa (HS) causes substantial morbidity and quality-of-life impairment. We examined demographic/clinical characteristics of patients with HS and treatment patterns, prevalence and healthcare resource utilisation/expenditures related to HS in the real-world.DesignRetrospective claims data of MarketScan Commercial, Medicare Supplemental and Medicaid databases (2009–2014).SettingUSA.ParticipantsPatients aged ≥12 years with ≥3 non-diagnostic outpatient or inpatient claims with an HS diagnosis code and ≥12 months continuous enrolment with medical and pharmacy benefits before (preindex) and after (postindex) the earliest diagnosis of HS (index) were included.ResultsThere were 11 325 Commercial/Medicare patients (mean age 37.4 years) and 5164 Medicaid patients (mean age 28.3 years). HS was more common in Medicaid than Commercial/Medicare patients (0.301% and 0.098%, respectively, in 2014). Cellulitis and psychiatric disorders were the most common comorbidities and oral antibiotics and narcotics were the most frequently prescribed drugs preindex, with ≥10% increase postindex in both populations. HS-related inpatient costs decreased while outpatient costs increased from preindex to postindex. Medicaid patients had several risk factors that may be associated with poor outcomes (eg, high rates of prescription pain medication use, comorbidities, drug discontinuation/interruption/holiday, emergency department (ED) visits and hospitalisation).ConclusionsCommercial/Medicare and Medicaid HS beneficiaries experience high comorbidity burden but use different treatment modalities to manage HS. Results suggest a substantial unmet need exists among this patient population, with Medicaid patients experiencing a particularly high burden of disease and expensive healthcare resource utilisation.
Neurodevelopmental disorders among term infants exposed to antenatal corticosteroids during pregnancy: a population-based study
Authors: Melamed Nir , Asztalos Elizabeth , Murphy Kellie , Zaltz Arthur , Redelmeier Donald , Shah Baiju R , Barrett Jon 
Published: October 2019

ObjectiveAn increasing proportion of fetuses are exposed to antenatal corticosteroids (ACS). Despite their immediate beneficial effects, the long-term safety of ACS has been an ongoing source of concern. In the current study, we assessed the likelihood of neurodevelopmental problems among term infants exposed to ACS earlier in pregnancy compared with non-exposed term infants.DesignRetrospective cohort study (2006–2011). Median duration of follow-up was 7.8 (IQR 6.4–9.2) years.SettingPopulation-based study, Ontario, Canada.ParticipantsAll live singleton infants born at term (≥370/7weeks gestation) (n=529 205).ExposureACS during pregnancy.Primary and secondary outcome measuresA composite of diagnostic or billing codes reflecting proven or suspected neurodevelopmental problems during childhood including audiometry testing, visual testing or physician service claim with a diagnosis code related to a suspected neurocognitive disorder.ResultsAt 5 years of age, the cumulative rate for the primary outcome was higher among infants exposed to ACS compared with non-exposed infants: 61.7% (3346/5423) vs 57.8% (302 520/523 782), respectively (p<0.001; number needed to harm (NNH)=25, 95% CI 19 to 38; adjusted HR (aHR) 1.12, 95% CI 1.08 to 1.16). Similar findings were observed for each of the individual components of the primary outcome: 15.3% vs 12.7% for audiometry testing (p<0.001; NNH=39, 95% CI 29 to 63; aHR 1.18, 95% CI 1.11 to 1.25); 45.4% vs 43.5% for visual testing (p=0.006; NNH=54, 95% CI 31 to 200; aHR 1.08, 95% CI 1.04 to 1.12) and 25.8% vs 21.6% for suspected neurocognitive disorder (p<0.001; NNH=24, 95% CI 19 to 33; aHR 1.16, 95% CI 1.10 to 1.21).ConclusionsWe found an association among term infants between exposure to ACS during pregnancy and healthcare utilisation during childhood related to suspected neurocognitive and neurosensory disorders.
Effectiveness and safety of early intramuscular botulinum toxin injections to prevent shoulder deformity in babies with brachial plexus birth injury (POPB-TOX), a randomised controlled trial: study protocol
Authors: Pons Christelle , Eddi Dauphou , Le Gal Gregoire , Garetier Marc , Ben Salem Douraied , Houx Laetitia , Fitoussi Franck , Quintero Nathaly , Brochard Sylvain 
Published: October 2019

IntroductionIn children with brachial plexus birth injury (BPBI), denervation of the shoulder muscles leads to bony deformity in the first months of life, reducing active and passive range of motion (ROM) and causing activity limitation. The aim of this multicentre randomised controlled trial is to evaluate the effectiveness of botulinum toxin injections (BTI) in the shoulder internal rotator muscles of 12-month-old babies in limiting the progression of posterior subluxation of the glenohumeral joint, compared with a sham procedure mimicking BTI. The secondary aims are to evaluate the effectiveness of BTI in (1) limiting the progression of glenoid retroversion and three-dimensional (3D) deformity and (2) improving shoulder ROM and upper limb function, as well as to confirm the tolerance of BTI.Methods and analysisSixty-two babies with unilateral BPBI and a risk of posterior humeral head subluxation will be included. Only those with at least 7% posterior subluxation of the humeral head compared with the contralateral shoulder on the MRI will be randomised to one of two groups: ‘BTI’ and ‘Sham’. The BTI group will receive BOTOX injections at the age of 12 months in the internal shoulder rotator muscles (8 UI/kg). The sham group will undergo a sham BTI procedure. Both groups will undergo repeated shoulder MRI at 18 months of age to quantify changes in the percentage of posterior migration of the humeral head (primary outcome), glenoid version and 3D bone deformity. Clinical evaluations (passive shoulder ROM, active movement scale) will be carried out at baseline and 15 and 18 months of age. The mini-assisting hand assessment will be rated between 10 and 11 months and at 18 months of age. Adverse events will be recorded at least monthly for each child.Ethics and disseminationFull ethical approval for this study has been obtained. The findings will be disseminated in peer-reviewed publications.Trial registration numberEudraCT: 2015-001402-34 in European Clinical Trial database;NCT03198702in Clinical Trial database; Pre-results.
Interprofessional learning in immediate life support training does effect TEAM performance during simulated resuscitation
Authors: Morse Jeremy Charles , Brown Craig William , Morrison Ian , Wood Caroline 
Published: October 2019

Aim of the studyTo assess performance in a simulated resuscitation after participating in either an interprofessional learning (IPL) or uniprofessional learning (UPL) immediate life support (ILS) training course.IntroductionThe Team Emergency Assessment Measure (TEAM) is routinely used in Resuscitation Council (UK) Advanced Life Support courses. This study used the psychometrically validated tool to assess if the delivery of an IPL ILS to final year medical and nursing students could improve overall behavioural performance and global TEAM score.MethodsA randomised study of medical (n=48) and nursing (n=48) students, assessing performance in a simulated resuscitation following the IPL or UPL ILS courses. Postcourse completion participants were invited back to undertake a video-recorded simulated-resuscitation scenario. Each of these were reviewed using the TEAM tool, at the time by an experienced advanced life support instructor and subsequently by a clinician, independent to the study and blinded as to which cohort they were reviewing.ResultsInter-rater reliability was tested using a Bland-Altman plot indicating non-proportional bias between raters. Parametric testing and analysis showed statistically significant higher global overall mean TEAM scores for those who had attended the IPL ILS courses.ConclusionOur results demonstrate that an IPL approach in ILS produced an increased effect on TEAM scores with raters recording a significantly more collaborative team performance. A postscenario questionnaire for students also found a significantly improved experience within the team following the IPL course compared with those completing UPL training. Although this study shows that team behaviour and performance can change and improve in the short-term, we acknowledge further studies are required to assess the long-term effects of IPL interventions. Additionally, through this type of study methodology, other outcomes in regard to resuscitation team performance may be measured, highlighting other potential benefit to patients, at level four of Kirkpatrick’s hierarchy.
Cardiometabolic health in adolescence and its association with educational outcomes
Authors: Correa-Burrows Paulina , Blanco Estela , Gahagan Sheila , Burrows Raquel 
Published: October 2019

AimTo explore the association of selected cardiometabolic biomarkers and metabolic syndrome (MetS) with educational outcomes in adolescents from Chile.MethodsOf 678 participants, 632 (52% males) met criteria for the study. At 16 years, waist circumference (WC), systolic blood pressure, triglycerides (TG), high-density lipoprotein and glucose were measured. A continuous cardiometabolic risk score (zMetS) using indicators of obesity, lipids, glucose and blood pressure was computed, with lower values denoting a healthier cardiometabolic proﬁle. MetS was diagnosed with the International Diabetes Federation/American Heart Association/National Heart, Lung, and Blood Institute joint criteria. Data on high school (HS) graduation, grade point average (GPA), college examination rates and college test scores were collected. Data were analysed controlling for sociodemographic, lifestyle and educational confounders.ResultzMetS, WC, TG and homeostatic model assessment of insulin resistance at 16 years were negatively and significantly associated with the odds of completing HS and taking college exams. Notably, for a one-unit increase in zMetS, we found 52% (OR: 0.48, 95% CI 0.227 to 0.98) and 39% (OR: 0.61, 95% CI 0.28 to 0.93) reduction in the odds of HS completion and taking college exams, respectively. The odds of HS completion and taking college exams in participants with MetS were 37% (95% CI 0.14 to 0.98) and 33% (95% CI 0.15 to 0.79) that of participants with no cardiometabolic risk factors. Compared with adolescents with no risk factors, those with MetS had lower GPA (515 vs 461 points; p=0.002; Cohen’sd=0.55). Adolescents having the MetS had significantly lower odds of passing the mathematics exam for college compared with peers with no cardiometabolic risk factors (OR: 0.49; 95% CI 0.16 to 0.95).ConclusionIn Chilean adolescents, cardiometabolic health was associated with educational outcomes.
Single-Cell RNA Sequencing Reveals a Developmental Hierarchy in Langerhans Cell Histiocytosis
Authors: Gruber Tanja A. 
Published: October 2019

Abstract

Summary:
In this issue of Cancer Discovery, Halbritter and colleagues utilize single-cell RNA sequencing to dissect the cellular hierarchy in Langerhans cell histiocytosis. They identified a remarkably consistent composition of 14 cellular subsets across all patients with a range of clinical spectrums consistent with a shared developmental hierarchy driven by key transcriptional regulators.
See related article by Halbritter et al., p. 1406.
The rarest of the rare: rediscovery and status of the critically endangered Belem Curassow, Crax fasciolata pinima (Pelzeln, 1870)
Authors: Alteff Eduardo França , Gonsioroski Gustavo , Barreiros Marcelo , Oliveira Torres Leonardo Gabriel Campos de , Camilo André Restel , Mozerle Hugo Borghezan , Sousa Antônio Emanuel Barreto Alves de , Medolago César Augusto Bronzatto , Martínez Carlos , Lima Diego Mendes , Ubaid Flávio Kulaif , Mendonça Eloisa Neves , Tomotani Barbara Mizumo , Silveira Luís Fábio 
Published: October 2019

The Belem Curassow (Crax fasciolata pinima) is one of the most endangered birds in South America, without sightings of birds in the wild for 40 years. This subspecies is nationally and internationally classified as critically endangered and close to extinction, suffering from poaching and deforestation in its range. Here we present new records of free-living individuals made on three indigenous lands in Pará and Maranhão states: in part of Terra Indígena Mãe Maria, Bom Jesus do Tocantins, Pará; in locations within the Reserva Biológica do Gurupi/Terra Indígena Alto Turiaçu, Centro Novo do Maranhão, Maranhão; and around the Terra Indígena Rio Pindaré, Alto Alegre do Pindaré, Maranhão. We also provide recommendations to protect this bird via a dedicated conservation program which includes finding new individuals in non-sampled areas (north of BR-222), estimating population size, enhancing taxonomic and natural history knowledge, capturing wild animals in order to start urgent ex situ conservation programs, and developing environmental awareness programs with the local and indigenous populations.