bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostyka gorączki u pacjentki z rozpoznaniem przewlekłej białaczki limfocytowej
Authors: Rymkiewicz Emilia , Piebiak Agnieszka , Chrapko Beata , Szumiło Justyna , Grząśko Norbert , Giannopoulos Krzysztof 
Published: September 2019

StreszczeniePrzewlekła białaczka limfocytowa (PBL) jest najczęstszym nowotworem układu krwiotwórczego u dorosłych. Charakteryzuje ją 1zróżnicowany przebieg kliniczny, od postaci łagodnych, niewymagających leczenia, do agresywnych, kiedy konieczna jest immunoche- mioterapia. W sytuacji pojawienia się objawu w postaci gorączki należy wziąć pod uwagę zarówno wystąpienie progresji choroby, in- fekcji związanej z defektem immunologicznym występującym w jej przebiegu, jak również zmianę charakteru nowotworu w kierunku chłoniaka o dużej złośliwości. W opisanym poniżej przypadku przedstawiono przebieg kliniczny oraz problemy diagnostyczno-tera- peutyczne u pacjentki, u której 2 lata po rozpoznaniu PBL rozpoznano chłoniaka Hodgkina w przebiegu transformacji richterowskiej.
Kesembuhan Fraktur Tulang Femur Kelinci Pasca Implantasi Bahan Cangkok Demineralisasi Serbuk Tulang Sapi Bali
Authors: Asih Ni Putu Trisna , Wirata I Wayan , Sudimartini Luh Made , Winaya Ida Bagus Oka , Kardena I Made , Gorda I Wayan 
Published: September 2019

Tujuan penelitian ini untuk mengetahui gambaran mikroskopis kesembuhan fraktur tulang femur kelinci pascaimplantasi dengan bahan cangkok demineralisasi serbuk tulang sapi bali. Kelinci lokal jantan sebanyak 12 ekor digunakan dalam penelitian ini yang dibagi menjadi dua kelompok secara acak. Kelompok A adalah tiga ekor kelinci yang digunakan sebagai kontrol, yaitu kelinci pada diaphysis tulang femurnya dibor dengan diameter 5 mm dan kedalaman bor hingga mencapai medula, tanpa pemberian bahan cangkok. Kelompok B adalah 9 ekor kelinci yang dibor seperti kelompok A dan diberikan serbuk cangkok tulang pada bagian tulang yang dibor. Pada minggu ke-2, ke-4, dan ke-6 pascaoperasi dilakukan biopsi tulang masing-masing satu ekor kelinci pada kelompok A dan tiga ekor kelinci pada kelompok B. Pengamatan mikroskopis dilakukan dengan membuat sediaan tulang diwarnai dengan Hematoksilin-Eosin (HE). Hasil penelitian menunjukkan bahwa proses kesembuhan tulang lebih cepat terjadi pada kelompok B yang diamati dari minggu ke-2 sampai minggu ke-6 dengan sel radang terlihat sedikit dan jumlahnya berkurang setiap pengamatan, adanya pertumbuhan osteoblas, osteoklas, osteosit, kartilago, tulang trabekula, neovaskularisasi dan proliferasi fibrolas lebih cepat dibandingkan kelompok A. Dapat disimpulkan, bahan cangkok asal tulang sapi bali mampu menginduksi proses kesembuhan tulang fraktur pada kelinci.
Penentuan Kadar Protein dan Fraksi Protein Crude Antigen Cysticercus cellulosae dari Isolat Lokal
Authors: Nugraha Leksana Aditya Kris , Swacita Ida Bagus Ngurah , Apsari Ida Ayu Pasti 
Published: September 2019

Sistiserkosis merupakan penyakit parasitik yang disebabkan oleh larva cacing pita yang disebut Cysticercus. Cysticercus yang ditemukan pada babi adalah Cysticercus cellulosae yang merupakan larva dari cacing pita Taenia solium. Tujuan penelitian ini adalah untuk mengetahui kadar dan fraksi protein Crude antigen C. cellulosae. C. cellulosae yang digunakan adalah isolat lokal yang diperoleh dari babi terinfeksi yang berasal dari Karangasem – Bali. Penentuan kadar protein larva dilakukan dengan menggunakan alat Invitrogen Quibit Fluorometer dan penentuan fraksi protein larva dengan teknik elektroforesis menggunakan SDS-PAGE. Hasil penelitian menunjukan bahwa kadar protein C. cellulosae isolat lokal sebesar 867 µg/ml. Sedangkan untuk fraksinasi protein larva diperoleh 6 bands protein dengan berat molekul: bands 1 = 120,5 kDa, bands 2 = 99,8 kDa, bands 3 = 60,8 kDa, bands 4 = 47,7 kDa, bands 5 = 35,6 kDa, dan bands 6 = 23,3 kDa.
Reaksi Pasar Terhadap Pelemahan Nilai Rupiah Pada Nilai Tukar US Dollar
Authors: Putra R. Egi Pradnya , Wirawati Ni Gusti Putu 
Published: September 2019

The sampling method used was purposive sampling with a total sample of 39 companies from the LQ45 stock index for the period February-July 2018. The data analysis technique used paired sample t-test with a significance level of 5% on normal distributed data and the Wilcoxon test on data not normal distribution. This study produces a significant difference between the abnormal return and trading volume activity before and after the weakening of the rupiah value on the US Dollar exchange rate against the LQ45 company stock listed on the IDX. The results of this study support the theory of market efficiency where the market responds to incoming information, and how that information can further influence the movement of securities prices towards new equilibrium prices.
Keywords: Market reaction, event study, weakening rupiah value, abnormal return, trading volume activity.
Pengaruh Penerapan E-Filling Pada Kepatuhan WPOP Pegawai Negeri Sipil Dengan Pemahaman Internet Sebagai Variabel Pemoderasi
Authors: Putra Agniveda I Gusti Ngurah Agung , Supadmi Ni Luh 
Published: September 2019

This study aims to determine the effect of the application of e-filling on the compliance of the civil servant taxpayers with an understanding of the internet as a moderating variable in the East Denpasar Primary Tax Office. The number of samples used in this study were 100 respondents out of 16,732 effective civil servant populations in East Denpasar Primary Tax Office. The method of determining the sample used was non-probability sampling with a purposive sampling technique. Data collection in this study was conducted by questionnaire method. The data analysis technique used is the analysis of Moderated Regression Analysis (MRA). The results showed that the application of e-filling had a positive effect on the compliance of the civil servant taxpayers and understanding the internet was not able to moderate the effect of implementing e-filling on the compliance of the civil servant taxpayers at East Denpasar Primary Tax Office.
Keywords: E-filling, understanding of the internet, taxpayers compliance.
Pengaruh Penerapan Akuntansi Pertanggungjawaban, Kompetensi dan Komitmen Organisasi Terhadap Kinerja Manajerial
Authors: Cahyani Kadek Novita , Damayanthi I Gst Ayu Eka 
Published: September 2019

Managerial performance is very important for a company because it can be used to measure the success of the company. A manager needs to implement a managerial control system that can be used to achieve the company goals. The purpose of this study is to obtain empirical evidence regarding the effect of applying accountability accounting, competence and organizational commitment to the managerial performance of the financial division on PT Pegadaian Kota Denpasar. Sampling technique that used in this study is non probability sampling with purposive sampling method. The amount of sample in this study are 52 samples. The analysis technique is multiple linear regression. Based on the results of the analysis shows that accountability accounting, competence, and organizational commitment have a positive effect on the managerial performance of financial division on PT. Pegadaian Kota Denpasar.
Keywords : Accountability accounting, competence, organizational commitment, managerial performance.
Pengaruh Komponen Kecerdasan Emosional pada Pemahaman Akuntansi
Authors: Sukma Mutiara Pramita Sari Made , Wirama Dewa Gede 
Published: September 2019

Accounting education in college is intended to educate students to work as professional accountants with knowledge in accounting. Understanding of accounting is the process to understand accounting both as knowledge and as a process or practice. Understanding of accounting can be influenced by emotional intelligence of each individual. The purpose of this study is to determine the effect of the components of emotional intelligence on accounting understanding. This research was conducted at the Faculty of Economics and Business, Udayana University. The number of samples was 111 students, using non probability sampling methods. Data collection is conducted through a questionnaire. The data analysis technique used is multiple linear regression analysis. Based on the results of the analysis it was found that the components of emotional intelligence had positive effects on accounting understanding. The higher self-recognition, self-control, motivation, empathy and social skills, the higher the understanding of accounting.
Keywords: Accounting, emotional intelligence, accounting students.
Pengaruh Profitabilitas, Struktur Aset, Likuiditas, Dan Pertumbuhan Penjualan Terhadap Struktur Modal Perusahaan Makanan Dan Minuman
Authors: Gunadhi Gede Bagus Dwiputra , Putra I Made Pande Dwiana 
Published: September 2019

The purpose of this research is to understand the effect of profitability, asset structure, liquidity, and sales growth on the capital structure of food and beverage companies listed on the IDX. This research was conducted at 19 food and beverage companies listed on the Indonesia Stock Exchange (IDX) in 2015-2017 by accessing the website www.idx.co.id. The sample used in this study was determined using a non probability sampling method by used purposive sampling technique, so the final sample used in this study amounted to 15 companies. The data collection method used is the nonparticipant observation method. The data analysis technique used is multiple linear regression analysis. The results of this study are that profitability and liquidity have a negative influence on the capital structure, while the asset structure and sales growth have a positive influence on capital structure.
Keywords: Profitability, asset structure, liquidit, sales growth, capital structure.
Pengaruh Kesadaran, Kualitas Pelayanan, Pengetahuan Perpajakan, Dan Sanksi Perpajakan Pada Kepatuhan Wajib Pajak Reklame
Authors: Permatasari Mirah , Lely Aryani M Ni Ketut 
Published: September 2019

Public awareness to comply with taxation obligations play an important role in tax revenue revenue. This study is intended to determine whether taxpayer awareness, service quality, tax knowledge, and perceptions of tax sanctions have an effect on advertisement taxpayer compliance in the Regional Revenue Board of Badung Regency.. The method of determining the sample in this study using incidental sampling techniques with the number of respondents as many as 54 taxpayers. The data analysis technique used is multiple linear regression analysis. The effect of taxpayer awareness, service quality, tax knowledge and perceptions about tax sanctions on advertisement tax compulsory compliance of 98.3%. The effect of taxpayer awareness on advertisement taxpayer compliance is 1%. The effect of service quality on advertisement taxpayer compliance is 2.2%. Knowledge of taxation on advertisement taxpayer compliance is 4.8%. The influence of taxpayer perceptions about tax sanctions on advertisement taxpayer compliance is 92% .
Keywords: Taxpayer Compliance, Taxpayer Awareness, Service Quality, Tax Knowledge, Taxpayer Perception About Tax Sanctions.
SPESIASI DAN BIOAVAILABILITAS Pb DAN Cu DALAM TANAH PERTANIAN ORGANIK DI BEDUGUL SERTA KANDUNGAN LOGAM TOTALNYA DALAM SAYUR BROKOLI
Authors: Siaka I M. , Nurcahyani H. , Manuaba I B. P. 
Published: September 2019

Bedugul area is a vegetable producing center in Bali that also develops organic farming. This study aimed to determine the bioavailability of Pb and Cu in an organic farm in Bedugul and the content of both metals in broccoli before planting and at harvest. Metal extraction was carried out through wet digestion and its bioavailability was determined by the application of the sequential extraction methods. The measurement of the two metals was accomplished by using AAS. The total Pb content in the organic soils before and after harvesting were found to be 746.102-897.3754 mg/kg and 277.778-328.88217 mg/kg, while Cu were of 93.1212-11-114.3259 mg/kg, and 48,608-92.3708 mg/kg, respectively. The bioavailability of Pb and Cu in soils before planting was different from that of at harvest. Pb metal in organic soil before planting which were readily bioavailable, bioavailable, and nonbioavailable were were found to be (17.80-21.62)%, (44.07-47.65)%, and (30.73-36, 89 )%, while Cu were of (5.02-7.89)%, (55.73-60.57)%, and (32.81-39.25)%, respectively. The total Pb and Cu contents in broccoli were of (27,2968-30,3621) mg/kg and (27,0303-30,0223) mg/kg, respectively.
Keywords: bioavailability, broccoli, organic agriculture soil, Pb and Cu, speciation
KADAR Fe DAN Zn DALAM KRIM KENTAL MANIS KEMASAN KALENG EXPIRE DAN NON EXPIRE MENGGUNAKAN HIDROGEN PEROKSIDA (H2O2) UNTUK DESTRUKSI BASAH SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA)
Authors: Go Putri , Sudiarta I W. , Suarya P. 
Published: September 2019

Sweetened condensed milk is generally packaged in a can which is made from iron and zinc. Iron and zinc can have corrosion with the increasing of contact time and changing condition so that they will contaminate the milk. The purpose of this research are to determine the best wet destruction method, find out the effect of adding 30% H2O2 at varied volume in the process of wet destruction, to find out Fe and Zn content in expire and non-expired sweetened condensed milk and to compare the results with the national quality standard. Sample was wet destructed by using variation of 70% HNO3: 30% H2O2 which is 3:0 (method A); 3:0.5 (method B) 3:1 (method C); 3:2 (method D) then the results were measured by using Atomic Absorption Spectrophotometer. Analysis of Fe used standard addition curve method whereas the analysis of Zn used calibration curve method. The results of the analysis showed that the best variation of HNO3:H2O2 in wet destruction method was 3:0.5 for Fe analysis and 3:2 for Zn analysis. The addition of 30% H2O2 at varied volume in wet destruction for Fe analysis gave significantly different results for non-expired sweetened condensed milk but were not significantly different for expired sweetened condensed milk. Whereas, the analysis of Zn gave significantly different results for both non-expired and expired sweetened condensed milk. The metal content in the expired and non-expired sweetened condensed milk which were wet destructed by using the best solvent compotition obtained 0,2759 and 0,7126 mg/kg for Fe and 4,1645 and 2,4367 mg/kg for Zn metal. The Fe and Zn content in the sweetened condensed milk are still below the maximum limit that set by SNI.
Keywords: Fe, H2O2, Atomic Absorption Spectrophotometer, sweetened condensed milk, Zn
AKTIVITAS DARI KUERSETIN SEBAGAI AGEN PENCERAH KULIT SECARA IN SILICO
Authors: Adnyani K. D. , Lestari L. W. E. , Prabowo H. , Siaka P. A. I. A. , Laksmiani N. P. L. 
Published: September 2019

Increasing melanogenesis process causes excessive melanin synthesis resulting in darkening of the skin color. The melanogenesis process requires mealnogenesis enzymes, one of which is tyrosinase-related protein 1. One of the flavonoid compounds that has the potential as a skin lightening agent is quercetin. The antioxidant activity of quercetin plays a very important role in antimelanogenesis. This study aims to determine the affinity and molecular mechanism of quercetin on the target protein tyrosinase-related protein 1 using in silico molecular docking method. Molecular docking is carried out through stages including optimization of the structure of quercetin compounds, preparation of the target protein tyrosinase-related protein 1, validation of the molecular docking method, and docking of quercetin on the tyrosinase-related protein 1. Docking of quercetin with tyrosinase-related protein 1 produces binding energy values of -7.81 kcal/mol, while docking of native ligand with tyrosinase-related protein 1 produces binding energy values of -5.39 kcal/mol. Quercetin has a strong affinity for tyrosinase-related protein 1 which is indicated by the binding energy from the docking results. Quercetin has activity as a skin whitening agent with in silico test with molecular mechanisms through inhibition of the activity of tyrosinase-related protein 1 enzyme.
Keywords: skin whitening agent, in silico, quercetin, tyrosinase-related protein 1
MOLECULAR DOCKING TERPINEN-4-OL SEBAGAI ANTIINFLAMASI PADA ATEROSKLEROSIS SECARA IN SILICO
Authors: Susanti N. M. P. , Laksmiani N. P. L. , Noviyanti N. K. M. , Arianti K. M. , Duantara I K. 
Published: September 2019

Atherosclerosis is a chronic inflammatory disease that begins with endothelial dysfunction, it caused fat accumulation and plaque growth in the inner arteries walls. Endothelial dysfunction will activate the Mitogen Activated Protein Kinase (MAPK) pathway involving ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins, as well as the Nuclear Factor Kappa B (NF-kB) pathway involving IKK proteins. Terpinen-4-ol is constituent found in the bangle rhizome. The purpose of this study were to determine the affinity and mechanisms of terpinen-4-ol against ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins as anti-inflammatory in atherosclerosis performed using molecular docking method. The study was conducted exploratively with several steps such as preparation and optimization of terpinen-4-ol structure, preparation of 3D ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins, validation method of molecular docking, and docking terpinen-4-ol in these proteins. The docking result are assessed from the binding energy and hydrogen bonds formed between terpinen-4-ol and proteins. The smaller value of binding energy terpinen-4-ol with target proteins showed the complex that form more stable. The result showed that terpinen-4-ol and has activity in inhibiting the inflammatory process because it is able to disturb ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins with respective bond energy values -5,12; -5,24; -5,08; -5,88; and -4,99 Kcal/mol. The molecular mechanism in inhibiting the activity of ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins is through the formation of hydrogen bonds in these proteins. These results show that terpinen-4-ol have the potential to inhibit inflammatory process and the formation of atherosclerotic plaque can be obstructed.
Keywords : atherosclerosis, terpinen-4-ol, molecular docking, in silico
SGLT-2 INHIBITOR: PILIHAN TERAPI BARU UNTUK PENDERITA DIABETES MELITUS TIPE 2
Authors: AMANDARI EKAJAYA 
Published: September 2019

Penyakit diabetes melitus tipe 2 (DMT2) merupakan suatu kondisi medis yang ditandai dengan adanya peningkatan kadar glukosa darah melebihi batas normal. World Health Organization (WHO) menyebutkan bahwa jumlah penderita DM di Indonesia mengalami peningkatan dari 8,4 juta penderita pada tahun 2000 menjadi 21,3 juta penderita pada tahun 2030, dimana 90% diantaranya merupakan penderita DMT2. Patofisiologi dari penyakit DMT2 adalah suatu proses yang kompleks dan melibatkan banyak faktor. Konsep ominous octet yang dikemukakan oleh Ralph DeFronzo memegang peranan penting untuk menjelaskan patofisiologi dari DMT2. Ginjal merupakan organ yang memiliki peran signifikan untuk mengendalikan glukosa darah agar tetap dalam batas yang normal, sehingga dipertimbangkan untuk menjadi target terapi obat baru. Sodium glucose co-transporters (SGLTs) diantaranya SGLT-2 memfasilitasi reabsorbsi glukosa kedalam plasma. Farmakokinetika dari SGLT-2 inhibitor secara umum menunjukkan bioavailabilitas yang baik saat diberikan melalui oral. Diabetes melitus merupakan faktor risiko terjadinya penyakit ginjal kronik (PGK) dan penyakit kardiovaskuler (PKV). Adanya mekanisme penghambatan pada SGLT-2 akan memberikan manfaat terhadap sistem reno-kardiovaskuler melalui penurunan glukosa darah, berat badan, dan tekanan darah. Penghambat SGLT-2 memiliki beberapa efek tambahan yang menguntungkan untuk sindrom metabolik, seperti penurunan berat badan, penurunan tekanan darah (terutama sistolik), serta penurunan asam urat serum
STANDARISASI SPESIFIK DAN NON-SPESIFIK SIMPLISIA DAN EKSTRAK ETANOL RIMPANG KUNYIT (Curcuma domestica Val.)
Authors: Cahya Dayu , Prabowo Heny 
Published: September 2019

Turmeric is a plant that included in Zingiberaceae. Turmerics often used as a traditional medicine to heal wounds, antibacterial, reduces intestine motility, reduce unpleasant body odor, treats fever, diarrhea, and many more. Standardization is performed by examining turmeric rhizome simpicia and extract. Standardization is carried out to guarantee the quality of traditional raw materials and requirements for reproducibility of pharmaceutical and therapeutic qualities. Parameters that have been used in this research are macroscopic test, microscopic test, total ash content test, acid insoluble ash content test, water soluble simplicia content test, ethanol soluble simplicia content test, shrinkage drying test, and Phytochemistry screening qualitatively. From the results, turmeric simplicia has met the requirements, while turmeric extract has not eligible in requirements, because its acid insoluble ash content are not eligible. This expected because of the impurities which contamine the extract are silica and sand. Silica can cuts the mucosa of the throat when used it orally. Turmeric extract in this research does not eligible and cannot be used for the next step.
Molecular Docking Terpinen-4-ol pada Protein IKK sebagai Antiinflamasi pada Aterosklerosis secara In Silico
Authors: Dewi Putu Pradnya Pramita 
Published: September 2019

ABSTRACT

Atherosclerosis is a chronic inflammatory disease that begins with endothelial dysfunction, it caused fat accumulation and plaque growth in the inner arteries walls. Endothelial dysfunction will activate the Nuclear Factor Kappa B (NF-kB) pathway involving IKK proteins. Terpinen4-ol is constituent found in the bangle (Zingiber cassumunar) rhizome. The purpose of this study were to determine the affinity and mechanisms of terpinen-4-ol against IKK protein as anti-inflammatory in atherosclerosis performed using molecular docking method. The docking result are assessed from the binding energy and hydrogen bonds formed between terpinen-4-ol and protein. The result showed that terpinen-4-ol has activity in inhibiting the inflammatory process because it is able to disturb IKK protein with bond energy values -4.89 kcal/mol. The molecular mechanism in inhibiting the activity of IKK protein through the formation of hydrogen bonds in these proteins. These result show that terpinen-4-ol has the potential to inhibiting inflammatory process and it caused the formation of atherosclerotic plaque can be obstructed.

Keywords: Atherosclerosis, Terpinen-4-ol, Molecular Docking, In Silico
Pengaruh Persepsi Kegunaan, Kemudahan Penggunaan dan Norma Subyektif pada Minat Berperilaku Penggunaan E-Billing
Authors: Ratnadi Ni Made Dwi , Widanaputra Anak Agung Gde Putu 
Published: September 2019

This study aims to examine the behavior of individual taxpayers that use e-billing. The study was conducted at the Primary Tax Office in the Province of Bali. Data was collected using surveys. The sample was selected using convenience non-probability sampling technique. The number of respondents analyzed was 120 people. A variance based structural equation modeling approach with the calculation process supported by the partial least square was used in data analysis. The results show that perceived usefulness has a positive effect on attitude toward using e-billing, ease of use has a positive effect on attitude toward e-billing, ease of use has a positive effect on the perceived usefulness. The attitude and subjective norms positively influence the interest of individual taxpayers in using the e-billing system in paying taxes.
Keyword: E-billing, perceived ease of used, usefulness, attitude