bluuebunny/crossref_metadata_2025_split huggingface dataset:
Injuries in male and female elite Korean wrestling athletes: a 10-year epidemiological study
Authors: Park Ki Jun , Lee Je Hoon , Kim Hyun Chul 
Published: November 2018

ObjectivesTo report injury patterns associated with the training activities of elite male and female South Korean wrestling athletes preparing for the Olympic Games.MethodsFrom 2008 to 2017, we prospectively collected data on elite wrestling athletes at the Korea National Training Center. Athletes were assessed by two sports medicine doctors, and data were stratified according to sex, wrestling style, weight class, injury location and injury severity. Χ2tests were used to compare groups. Injury risk was expressed in relative ratios with 95% confidence intervals (RR, 95% CI).ResultsThere were 238 male and 75 female elite wrestlers. Training time totalled 382 800 hours. We recorded 1779 injuries in 313 athletes aged >18 years (annual average, 4.04 injuries/athlete); 59% of these were mild injuries. When all athletes were considered, most injuries occurred in the lower extremities (37.5%), followed by the upper extremities (27.4%), trunk (25.4%) and the head and neck area (9.7%). Weight class significantly influenced injury severity for both wrestling styles among male athletes (Greco-Roman, P=0.031; freestyle, P=0.028), as well as among female freestyle wrestling athletes (P=0.013). The relative ratio of injury incidence for the lightweight class compared with the heavyweight class was high for Greco-Roman style compared with freestyle (RR 1.13, 95% CI 1.03 to 1.27; P=0.011).ConclusionsAmong male and female South Korean elite wrestling athletes training for the Olympic Games, most injuries were mild and occurred in the lower extremities. Weight class influenced injury severity in both wrestling styles, and lightweight athletes had higher injury rates.
Pre-participation health evaluation in adolescent athletes competing at Youth Olympic Games: proposal for a tailored protocol
Authors: Adami Paolo Emilio , Squeo Maria Rosaria , Quattrini Filippo Maria , Di Paolo Fernando Maria , Pisicchio Cataldo , Di Giacinto Barbara , Lemme Erika , Maestrini Viviana , Pelliccia Antonio 
Published: November 2018

ObjectiveTo promote sports participation in young people, the International Olympic Committee (IOC) introduced the Youth Olympic Games (YOG) in 2007. In 2009, the IOC Consensus Statement was published, which highlighted the value of periodic health evaluation in elite athletes. The objective of this study was to assess the efficacy of a comprehensive protocol for illness and injury detection, tailored for adolescent athletes participating in Summer or Winter YOG.MethodsBetween 2010 and 2014, a total of 247 unique adolescent elite Italian athletes (53% females), mean age 16±1,0 years, competing in 22 summer or 15 winter sport disciplines, were evaluated through a tailored pre-participation health evaluation protocol, at the Sports Medicine and Science Institute of the Italian Olympic Committee.ResultsIn 30 of the 247 athletes (12%), the pre-participation evaluation led to the final diagnosis of pathological conditions warranting treatment and/or surveillance, including cardiovascular in 11 (4.5%), pulmonary in 11 (4.5%), endocrine in five (2.0%), infectious, neurological and psychiatric disorders in one each (0.4%). Based on National and International Guidelines and Recommendations, none of the athletes was considered at high risk for acute events and all were judged eligible to compete at the YOG. Athletes with abnormal conditions were required to undergo a periodic follow-up.ConclusionsThe Youth Pre-Participation Health Evaluation proved to be effective in identifying a wide range of disorders, allowing prompt treatment, appropriate surveillance and avoidance of potential long-term consequences, in a significant proportion (12%) of adolescent Italian Olympic athletes.
Effects of body protection vests and experience levels in prevention of equestrian injuries
Authors: Andres Sarah A , Bushau-Sprinkle Adrienne M , Brier Michael E , Seger Yvette R 
Published: November 2018

ObjectivesTo investigate the risk reduction and benefit of wearing body protection/safety vests in equestrian sports.MethodsA comparison of equestrians wearing body protective vests and those not wearing vests was performed using incident report data of 718 participants in the United States Pony Clubs during 2011–2017. Data obtained included age, gender, certification level of member, type of activity, description of incident, description of injuries, what protective equipment was worn and other possible contributing factors.ResultsWhile wearing body protective vests when riding on the flat or for show jumping was not correlated with a decrease in injuries, wearing vests for cross country was correlated with decrease in reported injuries (p=0.036) and showed a trend towards a lower incident severity level (p=0.062). Wearing body protection during cross country reduced the relative risk of injury by 56%. While the volume of incidents varied with a rider’s experience level, the number of serious injuries did not appear to correlate with lesser equestrian experience.ConclusionsWhile equestrian sports are considered to have a certain degree of risk associated with them, there are ways to make them safer. Wearing safety equipment, such as helmets and body protection, and obtaining education and experience can lessen the chance of incurring serious injuries.
NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: a CELAC study
Authors: Cheminant Morgane , Bruneau Julie , Malamut Georgia , Sibon David , Guegan Nicolas , van Gils Tom , Cording Sascha , Trinquand Amélie , Verkarre Virginie , Lhermitte Ludovic , Brousse Nicole , Jannot Anne-Sophie , Khater Sherine , Frenzel Laurent , Delarue Richard , Suarez Felipe , Marçais Ambroise , Mulder Chris JJ , Macintyre Elizabeth , Asnafi Vahid , Pouyet Laurent , Bonnafous Cécile , Lhospice Florence , Molina Thierry Jo , Meresse Bertrand , Cellier Christophe , Cerf-Bensussan Nadine , Hermine Olivier 
Published: November 2018

ObjectivesPrimary GI T-cell lymphoproliferative diseases (T-LPD) are heterogeneous entities, which raise difficult diagnosis and therapeutic challenges. We have recently provided evidences that lymphomas complicating coeliac disease (CD) arise from innate-like lymphocytes, which may carry NK receptors (NKRs).DesignNKRs expression was compared by flow cytometry in intraepithelial lymphocytes (IEL) from CD, type I or type II refractory CD (RCD). NKp46 was next assessed by immunohistochemistry in paraffin-embedded biopsies from 204 patients with CD, RCDI, RCDII or GI T-cell lymphomas and from a validation cohort of 61 patients. The cytotoxic properties of an anti-NKp46 monoclonal antibody conjugated to pyrrolobenzodiazepine (PBD) was testedex vivoin human primary tumour cells isolated from fresh duodenal biopsies.ResultsNKp46 (but not CD94, NKG2A, NKG2C, NKG2D) was significantly more expressed by malignant RCDII IEL than by normal IEL in CD and RCDI. In paraffin biopsies, detection of >25 NKp46+ IEL per 100 epithelial cells discriminated RCDII from CD and RCDI. NKp46 was also detected in enteropathy-associated T-cell lymphomas (EATL, 24/29) and in monomorphic epitheliotropic intestinal T-cell lymphomas (MEITL, 4/4) but not in indolent T-LPD (0/15). Treatment with anti-NKp46-PBD could efficiently and selectively kill human NKp46+ primary IELex vivo.ConclusionNKp46 is a novel biomarker useful for diagnosis and therapeutic stratification of GI T-LPD. Strong preclinical rationale identifies anti-NKp46-PBD as a promising therapy for RCDII, EATL and MEITL.
Effect of seawalls on tsunami evacuation departure in the 2011 Great East Japan Earthquake
Authors: Troncoso Parady Giancarlos , Tran Bryan , Gilmour Stuart 
Published: November 2018

ObjectiveTo quantitatively evaluate the effect of seawalls on tsunami evacuation departure.MethodsA mixed-effect Cox proportional-hazards regression model was applied to evacuation behavioural data obtained from a probability survey of survivors of the 2011 Great East Japan Earthquake and Tsunami in Iwate and Miyagi prefectures.FindingsPresence of a seawall higher than the forecast tsunami height at any given time reduces the likelihood of prompt evacuation by 30%. Findings suggest the existence of a false sense of security among residents deriving from the presence of seawalls.ConclusionPrompt evacuation is a key factor affecting survival. The effect of seawalls on evacuation decisions is an important policy consideration. More work is needed in disaster preparedness education and in the way tsunami warnings are given, taking into consideration the risk of forecast error. Priority should be given to promoting prompt evacuation and educating residents as to the uncertainty of tsunami forecasting, to ensure that residents do not ignore evacuation warnings due to false impressions of the safety provided by seawalls.
Progression of subclinical and clinical cardiovascular disease in a UK SLE cohort: the role of classic and SLE-related factors
Authors: Haque Sahena , Skeoch Sarah , Rakieh Chadi , Edlin Helena , Ahmad Yasmeen , Ho Pauline , Gorodkin Rachel , Alexander M Yvonne , Bruce Ian N 
Published: November 2018

ObjectivesWe aimed to describe the rate and determinants of carotid plaque progression and the onset of clinical cardiovascular disease (CVD) in a UK SLE cohort.MethodsFemale patients with SLE of white British ancestry were recruited from clinics in the North-West of England and had a baseline clinical and CVD risk assessment including measurement of carotid intima–media thickness (CIMT) and plaque using B-mode Doppler ultrasound. Patients were followed up (>3.5 years after baseline visit) and had a repeat carotid Doppler to assess progression of plaque and CIMT. Clinical CVD events between visits were also noted.ResultsOf 200 patients with a baseline scan, 124 (62%) patients had a second assessment at a median (IQR) of 5.8 (5.2–6.3) years follow-up. New plaque developed in 32 (26%) (4.5% per annum) patients and plaque progression was observed in 52 (41%) patients. Factors associated with plaque progression were older age (OR 1.13; 95%  CI 1.06 to 1.20), anticardiolipin (OR 3.36; 1.27 to 10.40) and anti-Ro (OR 0.31; 0.11 to 0.86) antibodies. CVD events occurred in 7.2% over 5.8 years compared with 1.0% predicted using the Framingham risk score (p<0.001). Higher triglycerides (OR 3.6; 1.23 to 10.56), cyclophosphamide exposure ‘ever’ (OR 16.7; 1.46 to 63.5) and baseline Systemic Lupus International Collaborating Clinics damage index score (OR 9.62; 1.46 to 123) independently predicted future CVD events.ConclusionAccelerated atherosclerosis remains a major challenge in SLE disease management. A more comprehensive approach to CVD risk management taking into account disease factors such as severity and anticardiolipin antibody status may be necessary to improve CVD outcomes in this high-risk population.
Validation of the Cutaneous Lupus Erythematosus Disease Area and Severity Index and pSkindex27 for use in childhood-onset systemic lupus erythematosus
Authors: AlE'ed Ashwaq , Aydin Pinar Ozge Avar , Al Mutairi Nora , AlSaleem Alhanouf , Sonmez Hafize Emine , Henrickson Michael , Huggins Jennifer L , Ozen Seza , Al-Mayouf Sulaiman M , Brunner Hermine I 
Published: November 2018

ObjectiveTo determine the measurement properties of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and the paediatric adaptation of the Skindex29 (pSkindex27) when used in childhood-onset SLE (cSLE).MethodsPatients with mucocutaneous involvement of cSLE were evaluated at the study entry and 6 months later. Besides the CLASI and pSkindex27, the Pediatric Quality of Life Inventory Generic Core scale (PedsQL-GC), its Rheumatology Module (PedsQL-RM), the SLE Disease Activity Index (SLEDAI) and the SLE Damage Index (SDI) were completed.ResultsThe CLASI and pSkindex27 had high internal consistency (both Cronbach α>0.82). Children were able to complete the pSkindex27, with self-report and caregiver proxy-reports showing excellent agreement (intraclass correlation coefficient=0.97). The CLASI Activity Score (CLASI-A) was strongly correlated with the mucocutaneous domain score of the SLEDAI as was the CLASI Damage Score (CLASI-D) with that of the SDI (both: Spearman correlation coefficients (rs) >0.68). pSkindex27 summary scores were moderately correlated with those of the PedsQL-GC and PedsQL-RM (all: rs>|0.51|), the CLASI-A and CLASI-D (both: rs>0.64), respectively. Patients who experienced a >50% improvement of the CLASI-A between study visits had significantly higher PedsQL-GC and pSkindex27 scores than those without improvement of mucocutaneous features.ConclusionBoth CLASI and pSkindex27 are useful assessment tools in cSLE, active and chronic mucocutaneous lesions and their changes over time can be measured using the CLASI and the pSkindex27 can capture the impact of mucocutaneous involvement on patient health-related quality of life.
Comparison of Performance Between a Short Categorized Lifestyle Exposure-based Colon Cancer Risk Prediction Tool and a Model Using Continuous Measures
Authors: Liu Ying , Colditz Graham A. , Rosner Bernard A. , Dart Hank , Wei Esther , Waters Erika A. 
Published: November 2018

Abstract
Risk prediction models that estimate an individual's risk of developing colon cancer could be used for a variety of clinical and public health interventions, including offering high-risk individuals enhanced screening or lifestyle interventions. However, if risk prediction models are to be translated into actual clinical and public health practice, they must not only be valid and reliable, but also be easy to use. One way of accomplishing this might be to simplify the information that users of risk prediction tools have to enter, but it is critical to ensure no resulting detrimental effects on model performance. We compared the performance of a simplified, largely categorized exposure-based colon cancer risk model against a more complex, largely continuous exposure-based risk model using two prospective cohorts. Using data from the Nurses’ Health Study and the Health Professionals Follow-up Study we included 816 incident colon cancer cases in women and 412 in men. The discrimination of models was not significantly different comparing a categorized risk prediction model with a continuous prediction model in women (c-statistic 0.600 vs. 0.609, Pdiff = 0.07) and men (c-statistic 0.622 vs. 0.618, Pdiff = 0.60). Both models had good calibration in men [observed case count/expected case count (O/E) = 1.05, P &gt; 0.05] but not in women (O/E = 1.19, P &lt; 0.01). Risk reclassification was slightly improved using categorized predictors in men [net reclassification index (NRI) = 0.041] and slightly worsened in women (NRI = −0.065). Categorical assessment of predictor variables may facilitate use of risk assessment tools in the general population without significant loss of performance.
Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish
Authors: Goldshmit Yona , Tang Jean Kitty K. Y. , Siegel Ashley L. , Nguyen Phong D. , Kaslin Jan , Currie Peter D. , Jusuf Patricia R. 
Published: November 2018

Abstract
Background
Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently regenerate neural damage including after spinal cord injury. The mammalian spinal cord shows very limited regeneration and neurogenesis, resulting in permanent life-long functional impairment. Therefore, there is an urgent need to identify the cellular and molecular mechanisms that can drive efficient vertebrate neurogenesis following injury. A key pathway implicated in zebrafish neurogenesis is fibroblast growth factor signaling.

Methods
In the present study we investigated the roles of distinct fibroblast growth factor members and their receptors in facilitating different aspects of neural development and regeneration at different timepoints following spinal cord injury. After spinal cord injury in adults and during larval development, loss and/or gain of Fgf signaling was combined with immunohistochemistry, in situ hybridization and transgenes marking motor neuron populations in in vivo zebrafish and in vitro mammalian PC12 cell culture models.

Results
Fgf3 drives neurogenesis of Islet1 expressing motor neuron subtypes and mediate axonogenesis in cMet expressing motor neuron subtypes. We also demonstrate that the role of Fgf members are not necessarily simple recapitulating development. During development Fgf2, Fgf3 and Fgf8 mediate neurogenesis of Islet1 expressing neurons and neuronal sprouting of both, Islet1 and cMet expressing motor neurons. Strikingly in mammalian PC12 cells, all three Fgfs increased cell proliferation, however, only Fgf2 and to some extent Fgf8, but not Fgf3 facilitated neurite outgrowth.

Conclusions
This study demonstrates differential Fgf member roles during neural development and adult regeneration, including in driving neural proliferation and neurite outgrowth of distinct spinal cord neuron populations, suggesting that factors including Fgf type, age of the organism, timing of expression, requirements for different neuronal populations could be tailored to best drive all of the required regenerative processes.
Effectiveness of implementation of “mental health nursing students’ clinical competency model” on academic performance of nursing students
Authors: Atashzadeh-Shoorideh Foroozan , Mohtashami Jamileh , Pishgooie Seyed Amir Hosein , Jamshidi Tayebeh , Sedghi Sara 
Published: November 2018

Background: Clinical nursing competence in mental health is one of the most important topics in theoretical and practical nursing training with many factors affecting it. The purpose of this study is to determine the impact of the implementation of the “mental health nursing students’ clinical competence model” on nursing students’ academic performance. Methods: This study is a semi experimental following one group of student nurses. “mental health nursing students’ clinical competence model” for undergraduate nursing student’s education was applied. The study population included 50 nursing students, who were studying from fifth semester to seventh semester and selected through census sampling. During the seventh semester after the completion of theoretical and practical courses in mental health nursing, re-evaluation was conducted and the scores before and after the implementation of the clinical competence model were compared. Results: Rate of clinical competency before the intervention, was estimated at the level of non-mastered; and after intervention was at the level of mastered, demonstrating a significant difference (p<0.001). Areas of clinical competency scores before and after the intervention were compared which showed significant difference in all the areas except the mental competency areas (p<0.05). Conclusions: The implementation of the “mental health nursing students’ clinical competence model” and appropriate planning for achievement of mental health nursing specialized competency can ensure the achievement of clinical competency by nursing students.
ПСИХОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ФУТБОЛЬНЫХ БОЛЕЛЬЩИКОВ: ФАНАТЫ И ХУЛИГАНЫ
Authors: Molchanova Elena Vladimirovna 
Published: November 2018

Цель. В статье представлено теоретическое и экспериментальное исследование психологических особенностей представителей околофутбольной субкультуры – «фанатов» и «хулиганов». Целью экспериментального исследования стало выявление особенностей социальной фрустрированности, агрессивности и акцентуаций характера футбольных болельщиков.Метод или методология проведения работы. Библиографический метод; психодиагностический метод: анкетирование, методика «Уровень социальной фрустрированности» Л.И. Вассермана; опросник агрессивности А. Басса – А. Дарки; методика определения акцентуаций характера Г. Шмишека; математико-статистической метод обработки данных.Результаты работы. Футбольные болельщики в целом имеют низкую социальную фрустрированность, при этом если для «фанатов» областями негативных эмоций являются материальное положение и проведение отпуска, то для «хулиганов» – это современная обстановка в обществе и государстве и сфера медицинского обслуживания. Средние значения агрессивности и враждебности респондентов имеют повышенные показатели. Обнаружены статистически значимые различия в подгруппах «хулиганов» и «фанатов» по показателям негативизма, вербальной и физической агрессии. Стоит отметить, что футбольные болельщики не имеют ярко выраженных акцентуаций характера, а наиболее выраженными типами акцентуаций характера у обеих подгрупп являются гипертимный, застревающий и демонстративный.Область применения результатов. Полученные результаты дополняют немногочисленные работы по теме футбольной субкультуры и позволяют оптимизировать организацию массовых футбольных мероприятий, более эффективно решать возникающие конфликтные ситуации.Выводы. Представители околофутбольной среды, относящие себя к «фанатам» и «хулиганам», имеют психологические особенности и могут рассматриваться по уровню агрессивности как разные группы.
Estresse Ocupacional: Uma análise sobre causas, consequências e prevenções em uma clínica médica na cidade de Juazeiro do Norte-CE
Authors: Alves Ana Lecia Pereira , Lima Márcia Maria Leite 
Published: November 2018

Uma boa saúde ocupacional é algo importante dentro de qualquer empresa, seja qual for o seu propósito, toda empresa deve conter profissionais qualificados para a fomentação das suas atividades organizacionais, onde estas por vez devem estar alinhadas a pessoas capacitadas que se preocupem com o bem-estar organizacional, quanto com a saúde ocupacional dos colaboradores. Esse estudo tem por objetivo geral, estudar quais os fatores influenciadores do estresse ocupacional em uma clínica médica na cidade de Juazeiro do Norte- CE. Seguido dos objetivos específicos que é analisar se a comunicação é um fator influenciador, verificar se a cultura organizacional favorece a desmotivação do indivíduo dentro da organização, identificar se a qualidade de vida dentro da organização é satisfatória e investigar os danos que o estresse ocupacional pode ocasionar a saúde do trabalhador dentro da organização. Para obter os resultados foi realizada uma pesquisa pelos métodos mistos Quanti-qualitativo, descritiva. Através do processo metodológico foi possível identificar os resultados que não foram satisfatórios aos objetivos, pois na pesquisa obteve-se que os agentes estressores são devidamente encarados e controlados se tornando assim fatores de crescimento ao colaborador.
Triptofano no Sono: Uma Revisão Sistemática baseada no Método PRISMA
Authors: Lima Leonardo Da Silva , Silva Carla Pequeno da 
Published: November 2018

O sono é um processo biológico que apresenta alternância com períodos de vigília, modulado por hormônios e funções neuronais, tais como mecanismos fisiológicos que modificam a temperatura corporal, produção de hormônios e função cardíaca. Anormalidades no sono podem acarretar em má qualidade de vida e a longo prazo em doenças metabólicas e cardiovasculares. Acredita-se que um aliado para o tratamento das desordens do sono seja o triptofano (TRP), que por sua vez, é um aminoácido precursor da melatonina e serotonina. O TRP e alguns dos seus produtos metabólicos, como serotonina e melatonina, participa da regulação do humor, do sono e dos ritmos circadianos e são usados para tratar insônia e apnéia do sono. O objetivo desta pesquisa foi identificar a eficácia do uso do triptofano no sono através de uma revisão sistemática no modelo PRISMA. A revisão sistemática foi realizada a partir de três bases de dados (PubMed, Lilacs e Scielo). Foram encontrados 1.034 artigos, sendo 876 da PubMed, 157 da Lilacs e 1 da Scielo, após a aplicação dos critérios de elegibilidade foram incluídos 8 artigos na revisão. Os estudos mostraram efeitos positivos da suplementação do triptofano no sono, este aminoácido mostrou-se ser eficaz até mesmo no tratamento de distúrbios relacionados ao sono.