bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robotic, laparoscopic or open hemihepatectomy for giant liver hemangiomas of over 10 cm in diameter
Authors: Hu Minggen , Chen Kuang , Zhang Xuan , Li Chenggang , Song Dongda , Liu Rong 
Published: August 2019

Abstract
Background To evaluate the clinical efficacy of robotic, laparoscopic, and open hemihepatectomy for giant liver hemangiomas. Methods From April 2011 to April 2017, consecutive patients who underwent hemihepatectomy for giant liver hemangiomas were included into this study. According to the type of operation, these patients were divided into the robotic hemihepatectomy (RH) group, the laparoscopic hemihepatectomy (LH) group, and the open hemihepatectomy (OH) group. The perioperative and short-term postoperative outcomes were compared among the three groups. The study was reported following the STROCSS criteria. Results There were no significant differences in age, sex, tumor location, body surface area (BSA), future liver remnant volume (FLR), standard liver volume (SLV), liver hemangioma volume, FLR/SLV, resected normal liver volume / resected volume, hepatic disease, rates of blood transfusion, liver function after 24 hours of surgery, operative morbidity and mortality among the three groups. Compared with patients in the RH group (n=19), and the LH group (n=13), patients in the OH group (n=25) had significantly longer postoperative hospital stay (P< 0.05), time to oral intake (P < 0.05), time to get-out-of-bed (P < 0.05), a higher VAS score after 24 hours of surgery (P < 0.05) and a shorter operative time (P < 0.05). There were no significant differences in these postoperative outcomes (P>0.05) between the RH group and the LH group. When the setup time in the RH group was excluded, the operative time of the RH group was significantly shorter than the LH group (P<0.05). There was no significant difference in the operative time between the RH group and the OH group (P>0.05). The intraoperative blood loss of the RH group was the least among the three groups (P<0.05) and the intraoperative blood loss of the LH group was less than the OH group (P<0.05). Discussion Robotic, laparoscopic, and open hemihepatectomy were safe and efficacious treatments for giant liver hemangiomas. Robotic and laparoscopic hemihepatectomy were significantly better than open hemihepatectomy in intraoperative blood loss, postoperative recovery and pain score. Compared with laparoscopic hemihepatectomy, robotic hemihepatectomy resulted in significantly less intraoperative blood loss and shorter operative time.
Cause and Predictors of Neonatal Mortality among Neonates admitted to Neonatal Intensive Care Units of Public Hospitals in eastern Ethiopia: Facilities based Prospective follow-up study
Authors: Desalew Assefa , Sintayehu Yitagesu , Teferi Nardos , Amare Firehiwot , Geda Bifitu , Worku Teshager , Abera Kebebush , Asefaw Abiyot 
Published: August 2019

Abstract
Background: The first month is the most crucial period for child survival. Neonatal mortality is stagnated in sub-Saharan Africa including Ethiopia. And the trend in reduction is slower than infant and child mortality. The facilities-based cause and predictor of neonatal death in the neonatal intensive care unit were not well documented in this study setting. Hence the aim of this study was to determine the cause and predictors of neonatal mortality among neonates admitted in neonatal intensive care units in eastern Ethiopia.
Method: Facilities-based prospective follow-up study was conducted among neonates admitted in neonatal intensive care units of public hospitals in eastern Ethiopia from November to December 2018. Data were collected using pre-tested, structured questionnaire and follow-up checklist. The main outcomes, cause of death was set by senior pediatricians and residents. Epi-Data 3.1 and SPSS 25 version software were used for entry and analysis. Binary logistic regression was used to find out the predictors of facilities-based neonatal mortality.
Result: The proportion of facilities-based neonatal mortality was 20%. The top five cause of death was a complication of prematurity 49%, birth asphyxia 37.8%, infection 32.6%, meconium aspiration syndrome 17.3% and congenital malformation 6.1%. Low birth weight, preterm births, length of stay, low 5 th minutes Apgar score, hyperthermia and initiation of feeding were predictors of neonatal death among Neonates admitted in neonatal intensive care units in public hospitals, eastern Ethiopia.
Conclusion
In summary, the proportion of facilities-based Neonatal death was unacceptably high. The main causes of death were preventable and treatable. Hence, early detection, anticipating high-risk newborns and timely intervention is very essential. Furthermore, early initiation of feeding and a better referral linkage to tertiary facilities could contribute for reduction of neonatal death in this setting.
Keywords: Facilities based study, Neonatal mortality, predictors, NICU, Ethiopia
Reliability of Standardized Reporting System of acute appendicitis in adults at low-dose 320-rows CT
Authors: Mahankali Shravan , Razek Ahmed Abdel , abubacker shefeek , chavan venugopal naik 
Published: August 2019

Abstract
Aim: To assess reliability of standardized reporting system of acute appendicitis at low-dose 320-rows CT.

Methods: Retrospective analysis CT of 78 patients with pathologically proven acute appendicitis. The study was performed at low-dose 320-rows CT. The image analysis was performed by 2 radiologists according to standardized reporting system of acute appendicitis.

Results: There was excellent overall of inter-observer agreement of both observers for standardized reporting system of acute appendicitis ( K = 0.89, 95% CI = 0.87-0.92, P = 0.001). There was good inter-observer agreement for visualization of appendix (K = 0.78, P = 0.001), tip diameter ( K = 0.75, P = 0.001), and single wall thickness of appendix ( K =0.77, P = 0.001). There was excellent inter-observer agreement for outer to outer wall diameter ( K = 0.82 , P = 0.001), mucosal hyper-enhancement ( K =0.80, P = 0.001), appendicolith ( K = 0.86, P = 0.001), gas in appendix ( K = 0.82, P = 0.001), surrounding fat stranding ( K = 0.81, P = 0.001), focal cecal thickening ( K = 0.85, P = 0.001), peri-appendiceal air ( K = 0.87, P = 0.001), peri-appendicular fluid collection, phlegmon, or abscess ( K = 0.82, P = 0.001), and right ovary cyst ( K = 0.83, P = 0.001).

Conclusion: we concluded that excellent reliability of standardized reporting system of acute appendicitis in adults using low-dose 320-rows CT.
Adolescent pregnancy and parenting: Perceptions of healthcare providers
Authors: Govender Desiree , Naidoo Saloshni , Taylor Myra 
Published: August 2019

Abstract
Background

Adolescent pregnancy and parenting have attracted much attention as global public health and social concerns. Several studies have reported the prevalence of adverse maternal and child health outcomes due to adolescent pregnancy and it has been highlighted that the care rendered by healthcare providers plays a pivotal role in the health and well-being of pregnant and parenting adolescents. However, a dearth of available literature suggests that the role of healthcare providers as a source of sexual-related and reproductive health information is limited, regarding adolescent women in general.

Aim

The aim of this study was to explore healthcare providers’ perceptions of adolescent pregnancy and parenting.

Methods

A descriptive qualitative study was conducted at a district hospital in the Ugu district in KwaZulu-Natal, South Africa. Healthcare providers rendering care to pregnant and parenting adolescents were recruited from the maternity, antenatal, paediatrics, psychology, dietetics, physiotherapy and social work departments, as well as from the HIV/AIDS, STIs and TB (HAST) programme. The sample comprised 33 healthcare providers who were individually interviewed. The data were analysed using thematic analysis.

Results

The healthcare providers acknowledged that adolescent pregnancy is a problematic issue in Ugu district. Furthermore, they felt that the postpartum sexual-related and reproductive health of adolescent mothers was not given priority. In the healthcare providers’ view, the problems experienced by pregnant and parenting adolescents were school dropout, financial constraints, breakdown of relationships, abandonment, stigmatisation, parenting and child rearing difficulties, and both physical and mental health problems. Some of the participants were of the opinion that healthcare services were not channelled towards pregnant and parenting adolescents

Conclusion

The findings will contribute to existing literature on adolescent pregnancy as perceptions of adolescent pregnancy and parenting were elicited from a diverse group of healthcare providers. When appropriately disseminated, the findings will assist relevant healthcare providers, administrators in healthcare institutions, policy makers, and officials of the Department of Health and the Department of Education in South Africa to address the lack of appropriate care for pregnant and parenting adolescents. Our findings also highlight the need for a multidisciplinary approach to the care of pregnant and parenting adolescents.
Cost of incorrect application of antithrombotic prophylaxis prior to invasive procedures
Authors: Cuevas María Victoria , Martínez-Sancho Ignacio , Arribas Jana , García-Díaz Covadonga , Cuevas Beatriz 
Published: August 2019

Abstract
Background

We analyze the cost of an incorrect application, by the hematologist, of bridging anticoagulation in patients with low-risk atrial fibrillation (AF) needing interruption of treatment prior to a scheduled invasive procedure. Although not recommended, bridging therapy is widely used, resulting in avoidable costs and increased workload.

Methods

Observational retrospective study. We recorded demographic and clinical data including age, sex, type of procedure, use of bridging therapy with low molecular weight heparin (LMWH), and hemorrhagic complications within 30 days of acenocoumarol withdrawal.

Results

Acenocoumarol was stopped in 161 patients, 97 (60%) were male and 64 (40%) female. Average age was 76,11 ± 8,45 years. Procedures included: minor surgical intervention 58 (36%), colonoscopy 61 (38%), gastroscopy 11 (7%), breast biopsy 4 (2.5%), prostate biopsy 4 (2.5%), infiltration 5 (3%), and other 18 (11%). All patients received bridging anticoagulation with LMWH (40mg enoxaparin per day) 3 days before and 3 days after the procedure (6 doses). We used a total of 966 doses, at €4.5 per unit, resulted in €4,347 of total cost. No complications occurred in 156 patients (97%). Hemorrhage was observed in 5 cases: 1 major hemorrhage needing 6 days of hospital stay and transfusion, and 4 minor hemorrhages (2 patients needed Emergency attendance and 2 required hospital admission for 3 and 2 days, respectively). The cost of Emergency care was €237.36, and the cost of hospital stay was €6860.81 (€623.71 per day, for 11 days). The total cost of the incorrect application of the protocol was €11445.17.

Conclusion

Guidelines about bridging anticoagulation in low risk AF patients undergoing scheduled invasive procedures were not followed. This practice increments the complications and supposes an increase in costs besides to an inadequate use of the human resources.
Prognostic value of IGFBP7 in solid tumors: a meta analysis of 1,305 patients
Authors: Chen Borong , Huang Heqing , Xu Jiuhua , Li Lulu , Ye Weipeng , Zhu Zhipeng , Zeng Junjie , Li Jiayi , Huang Zhengjie 
Published: August 2019

Abstract
Background : Insulin-like growth factor-binding protein 7 (IGFBP7) has been detected to act as a cancer suppressor gene in different types of human carcinoma. Previous studies have presented controversial evidences between the expression of IGFBP7 and prognosis in solid tumors. A comprehensive meta-analysis was performed to investigate the prognostic role of IGFBP7 expression. Methods: The studies were identified through extensive electronic search of Web of Science, PubMed and Embase up to Jun 2019. The pooled hazard ratios (HR) with corresponding 95% confidence intervals (CI) for overall survival (OS) were calculated through univariate analysis and multivariate analysis to investigate the prognostic value of IGFBP7 expression . Heterogeneity, publication bias and subgroup analyses were also performed. Results: Seven eligible studies including 1,305 patients were extracted in this analysis. The pooled hazard ratio of univariable analysis for OS (HR = 0.60; 95% CI, 0.54–0.66, P < 0.001). The pooled hazard ratio of multivariate analysis for OS (HR = 0.57; 95% CI, 0.50–0.64, P < 0.001). In addition, subgroup analysis showed that low IGFBP7 expression was significantly associated with poor prognosis in patients with digestive system cancer. Conclusions: Low-expression of IGFBP7 was correlated strongly with worse OS, which indicated that IGFBP7 might be a new biomarker for prognosis prediction and a promising therapeutic target in solid tumors. Keywords: IGFBP7, prognosis, meta-analysis
The frequency and impact of admission hyperglycemia on short term outcome of acute stroke patients admitted to Tikur Anbessa teaching hospital, Addis Ababa, Ethiopia
Authors: Zewde Yared Zenebe , Mengesha Abenet Tafesse , Gebreyes Yeweyenhareg Feleke , Naess Halvor 
Published: August 2019

Abstract
Background:- Although acute stroke accompanied by hyperglycemia is often associated with worse prognosis, the relationship between hyperglycemia and stroke outcome has not been studied in Ethiopian patients. As better understanding of this potentially adverse influence on stroke outcome would provide guidance for stroke management and acute care. This study aimed to determine frequency of admission hyperglycemia and its impact on thirty day functional outcome and case fatality among acute stroke patients in an urban setting in Ethiopia.
Methods:- From July to December 2016, we collected information on 103 consecutive first ever acute stroke patients admitted within 72 hours of symptom onset to Tertiary hospital in Ethiopia. We obtained demographic, clinical and neuro-imaging data including capillary blood glucose at admission. National Institute of Health Stroke Scale and modified Rankin Scale were used to assess the baseline stroke severity and the degree of disability at thirty day.
Results:- A total of 103 first ever acute stroke patients were enrolled with, mean age = 55.5+ 15.3 years, 64.1% male, 65% under the age of 65 years, and 31.1% were farmers by occupation . Fifty one (49.5%) patients had a documented hyperglycemia at admission with median National Institute of Health Stroke Scale score of 14 and 3(2.9%) of them were later diagnosed with diabetes mellitus. The mean modified Rankin score at 30-day was 3.6 + 1.45 while 34 (79.1%) of hyperglycemic stroke survivors scored between 3 and 5. Older age >65 years (p = 0.037), admission hyperglycemia (p = 0.04) and stroke severity (p <0.001) were significantly correlated with poor functional outcome.
Conclusions:- High blood glucose on admission was significantly associated with sever disability in acute stroke patients, independent of the presence of diabetes mellitus. By establishing the negative impact of admission hyperglycemia on the neurological outcome, this study suggests that achieving normal blood glucose in the early stages of stroke could have a favorable impact on improved neurological outcome and quality of life for stroke patients. The study provides a rationale for acute stroke management that addresses the potentially adverse consequences of hyperglycemia at the time of presentation in an urban Ethiopian setting.
Fratura de agulha de sutura encontrada em espaço parafaríngeo Fracture of suture needle found in parapharyngeal space
Authors: Gross Dayane Jaqueline , Martins Luciana Dorochenko , Andreis Jéssica Daniela , Bortoluzzi Marcelo Carlos , Gonçalves Ramon César Godoy 
Published: August 2019

Introduction: Among the specialties, the maxillofacial surgery is one in which the professional is more exposed to accidents and complications. Thus, once the surgery is indicated, it is important to have a detailed surgical planning based on the physical examination and imaging examinations, in order to avoid iatrogenies. Objective: To report an atypical and rare case of suture needle fracture aftersuturing in minor oral surgery. Case report: Female patient, with the presence of a suture needle in parapharyngeal space, removed by surgical procedure under general anesthesia. Conclusion: The patient progresses well, without complications. Thus, if a fracture occurs, secondary complications can be avoided by promptly sending the patient to a specialized hospital to prevent the movement offragments in deeper tissue regions.
Structure and Sequence Based Analysis of Pullulanases: Understanding Dual Catalytic Mechanism
Authors: Vashishtha Shubham , Barwal Tushar S. , Bansal Saurabh 
Published: August 2019

Background:
Starch processing requires a combination of enzymes with other chemical
and physical processes, which increases cost and time. Enzymes used in these processes have a
characteristic (α/β)8 barrel domain architecture, although, show variable activity. Pullulanase type
1 and isoamylase act on α-1-6 linkage, amylase on α-1-4 linkage whereas pullulanase type 2 acts
on both α-1-6, and α-1-4 linkages of starch.

Objective:
This article focusses on elucidating the importance of sequence and structural-based
differences in pullulanase, that may lead to its dual catalytic nature.

Methods:
Initially, sequences and structures of pullulanase type 1, pullulanase type 2, amylase and
isoamylase were retrieved from the database (NCBI and PDB). Homology modelling using
SWISS-MODEL and PHYRE2 was carried out for predicting the structure of the enzymes with
unavailable structures. Further, the modelled structures were validated using ANOLEA, Verify 3D
and PROCHECK, structures with high confidence value were selected and used for analysis.
Finally, the selected structures were compared by using PDBefold, and their domain alignment and
analysis was performed manually using Pymol.

Results:
Modelled structures of pullulanase and isoamylase were validated and selected based on
the confidence score. Comparative analysis of complete structures low similarity between the
enzymes, although, domain analysis showed good similarity. Moreover, alignment of catalytic site
residues showed high similarities with the change in orientation of critical site residues (HIS 242,
ASP 347 and GLN 375).

Conclusion:
The change in orientation of active site residues along with the absence or presence of
few residues might play a crucial role in imparting dual functionality.
Development, Characterization and Anticancer Evaluation of Silver Nanoparticles from Dalbergia sissoo Leaf Extracts
Authors: Deep Aakash , Verma Mitali , Marwaha Rakesh K. , Sharma Arun K. , Kumari Beena 
Published: August 2019

Aim:
The objective behind this present work is the development and characterization of
silver nanoparticles from Dalbergia sissoo leaf extracts and the analysis of anticancer activity.

Methods:
Silver nanoparticles were prepared by using the aqueous solution of Dalbergia sisoo
leaf extract and silver nitrate. The formation of nanoparticles was determined by the color change
during the preparation of plant extract to metal ion in a fixed ratio. The prepared nanoparticles
were then characterized by TEM, FTIR, DLS, XRD, and SEM. Silver nanoparticles were also
evaluated for anticancer activity.

Results:
Synthesized silver nanoparticles were having good anticancer activity against MCF 7
cancer cell line as compared to the standard drug Doxorubicin.

Conclusion:
The particle size of nanoparticles was found to lie in the range of 10 to 50 nm.
Production of Citric Acid from the Fermentation of Pineapple Waste by Aspergillus niger
Authors: Ayeni Augustine. O. , Daramola Michael O. , Taiwo Olugbenga , Olanrewaju Omowonuola I. , Oyekunle Daniel T. , Sekoai Patrick T. , Elehinafe Francis B. 
Published: August 2019

Background:Citric acid, aside its uses as a cleaning agent, has varied applications in the chemical, pharmaceutical, and food industries. A biotechnological fermentation process is one of the easiest ways to satisfy the demands for this useful commodity.Methods:The fermentation of pineapple waste byAspergillus nigerfor the production of citric acid was investigated in this study. STATISTICA 8 release 7 (Statsoft, Inc. USA) statistical software was used for the design of experiments, evaluation, and optimization of the process using the central composite design (CCD), a response surface methodology approach. Lower-upper limits of the design for the operating parameters were temperature (25-35oC), fermentation time (35-96 h), pH (3-6), methanol concentration (1-7%) and glucose (15-85 g/L). Twenty-seven duplicated experimental runs were generated for the CCD route.Results & Conclusion:The optimal operating conditions were validated at 38 g/L of glucose concentration, 3% (v/v) of methanol, 50 h of fermentation time, pH of 4.3 and temperature of 30oC which yielded15.51 g/L citric acid. The statistical significance of the model was evaluated using a one-way analysis of variance. The validated predicted response values obtained from the statistical model showed close relationships with the experimental data.
Parents Knowledge and Awareness of their Children’s Oral Health in Riyadh, Saudi Arabia
Authors: Hamasha Abed A-H. , Rasheed Salman J. , Aldosari Mohammed M. , Rajion Zainul 
Published: August 2019

Objective:
To assess the parents’ knowledge and awareness of their children’s oral health in Riyadh, Saudi Arabia.

Methods:
The study was a cross-sectional analytical study of Saudi parents. A self-administered questionnaire was collected from 324 parents in public parks and malls. In addition to the demographic questions, parents’ knowledge about the number of primary teeth, tooth brushing, best time of dental visits, the meaning of plaque and calculus, the importance of fluoride, the relationship between primary and permanent teeth and the effect of oral health on general health were questioned. Data analysis included descriptive statistics and one-way analysis of variance and Bonferroni tests to assess differences in the mean number of correct answers among demographic categories. A p-value of 0.05 was set at a significant level.

Results:
The percentages of correct answers ranged from 26% to 75% depending on the type of questions. Only 26-28% could identify the number of primary teeth and the duration of teeth brushing. About one-third of parents knew the time of the first dental visit and the definition of plaque and calculus. Between 63-75% of parents believed that primary teeth can affect permanent teeth and mouth problems can affect general health. On average, 59.2% of participants provide incorrect answers about their children’s oral health. The numbers of correct answers were significantly increased by increasing education and income.

Conclusion:
Parents' knowledge and awareness of oral health among Saudi parents were poor. Special attention should be given to parents with low socioeconomic status who need to be educated about children oral health more.