bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Maternal HIV Infection and Placental Malaria on the Transplacental Transfer of Influenza Antibodies in Mother–Infant Pairs in Malawi, 2013–2014
Authors: Ho Antonia , Mapurisa Gugulethu , Madanitsa Mwayiwawo , Kalilani-Phiri Linda , Kamiza Steve , Makanani B , Ter Kuile Feiko O , Buys Amelia , Treurnicht Florette , Everett Dean , Mwapasa Victor , Widdowson Marc-Alain , Mcmorrow Meredith , Heyderman Robert S 
Published: August 2019

Abstract

Background
Maternal influenza vaccination protects infants against influenza virus infection. Impaired transplacental transfer of influenza antibodies may reduce this protection.

Methods
We conducted a cross-sectional study of influenza vaccine–naïve pregnant women recruited at delivery from Blantyre (urban, low malaria transmission) and Chikwawa (rural, high malaria transmission) in Southern Malawi. HIV-infected mothers were excluded in Chikwawa. Maternal and cord blood antibodies against circulating influenza strains A/California/7/2009, A/Victoria/361/2011, B/Brisbane/60/2008, and B/Wisconsin/1/2010 were measured by hemagglutination inhibition (HAI). We studied the impact of maternal HIV infection and placental malaria on influenza antibody levels in mother–infant pairs in Blantyre and Chikwawa, respectively.

Results
We included 454 mother–infant pairs (Blantyre, n = 253; Chikwawa, n = 201). HIV-infected mothers and their infants had lower seropositivity (HAI titer ≥1:40) against influenza A(H1N1)pdm09 (mothers, 24.3 vs 45.4%; P = .02; infants, 24.3 vs 50.5%; P = .003) and A(H3N2) (mothers, 37.8% vs 63.9%; P = .003; infants, 43.2 vs 64.8%; P = .01), whereas placental malaria had an inconsistent effect on maternal and infant seropositivity. In multivariable analyses, maternal HIV infection was associated with reduced infant seropositivity (A(H1N1)pdm09: adjusted odds ratio [aOR], 0.34; 95% confidence interval [CI], 0.15–0.79; A(H3N2): aOR, 0.43; 95% CI, 0.21–0.89). Transplacental transfer was not impaired by maternal HIV or placental malaria.

Conclusions
Maternal HIV infection influenced maternal antibody response to influenza A virus infection, and thereby antibody levels in newborns, but did not affect transplacental antibody transfer.
Purulent pneumococcal pericarditis, a vaccine-preventable illness
Authors: Rees Matthew J , Wilson Andrew 
Published: August 2019

Abstract
A 74-year-old gentleman presented to hospital with a 1-day history of acute onset pleuritic chest pain and fever. He was found to have widespread ST segment elevation on electrocardiogram, and blood cultures taken were positive for Streptococcus pneumoniae. Two days following admission the patient developed dyspnea, and a large pericardial effusion and right middle lobe consolidation were demonstrated on a computed tomography scan of the chest. A transthoracic echocardiogram confirmed the presence of a large circumferential pericardial effusion with multiple prominent adhesions and marked heterogenous thickening of the pericardium, without evidence of tamponade. Pericardiocentesis drained a purulent exudate positive for pneumococcal antigen. The occurrence of purulent pericarditis secondary to pneumococcal community-acquired pneumonia is rare in the modern antibiotic era and represents an often-lethal manifestation of invasive pneumococcal disease (IPD). IPD is a vaccine-preventable illness for which adult vaccination rates are low despite high morbidity. Healthcare professionals need to vaccinate older patients opportunistically.
Following the Money: Fenian Bonds, Diasporic Nationalism, and Distant Revolutions in the Mid-Nineteenth-Century United States*
Authors: Sim David 
Published: August 2019

Abstract
This article tracks and analyses the history of bonds issued by the Fenian Brotherhood in the 1860s to argue that US Americans could take part in a marketplace in distant revolutions in the mid-nineteenth century. In this period, various, disparate nationalist groups issued bonds, suggesting a commonly understood method of generating funds, sustaining sentimental attachment, and projecting the authority of authentic nation-states. The Civil War-era United States was a particularly fertile environment for the issuance of such bonds because of its traditions of free banking, the ease with which bonds might be floated to a public increasingly au fait with their operation, and a broad rhetorical sympathy with the distant revolutions for which these bonds stood. The debt these bonds represented acted as a sentimental form of ‘special money’ and, for Irish-Americans, as for other immigrant communities in the United States, they allowed participation in a transnational movement without ever leaving their immediate neighbourhood. Tracing their issuance and circulation, then, allows us to write a material, sentimental and social history of everyday transnationalism and anti-imperialism in the mid-nineteenth century. For later generations, this sentimental quality could and did devolve into a more immediately financial form, and the article concludes by identifying the redemption of these bonds as a significant step in legitimating the new Irish republic to a US audience.
The Logic of Leibniz’s Borrowed Reality Argument
Authors: Puryear Stephen 
Published: August 2019

AbstractLeibniz argues that there must be a fundamental level of simple substances because composites borrow their reality from their constituents and not all reality can be borrowed. I contend that the underlying logic of this ‘borrowed reality argument’ has been misunderstood, particularly the rationale for the key premise that not all reality can be borrowed. Contrary to what has been suggested, the rationale turns neither on the alleged viciousness of an unending regress of reality borrowers nor on the Principle of Sufficient Reason, but on the idea that composites are phenomena and thus can be real only insofar as they have a foundation in substances, from which they directly ‘borrow’ their reality. The claim that composites are phenomena rests in turn on Leibniz's conceptualism about relations. So understood, what initially looked like a disappointingly simple argument for simples turns out to be a rather rich and sophisticated one.
Do we need a book citation index for research evaluation?
Authors: Gingras Yves , Khelfaoui Mahdi 
Published: August 2019

Abstract
Given the importance of books and book chapters as vehicles of knowledge in social sciences and humanities (SSH) disciplines, it has previously been thought that the application of citation metrics to the evaluation of these disciplines should also include, in addition to journal articles, citations from books and book chapters. The main argument supporting this claim is the belief that top cited authors in journal articles and in monographs form two distinct populations. In this article, we compare the rankings of the most cited authors in three SSH disciplines (sociology, philosophy, and history), obtained by counting citations in the journal articles covered in the Web of Science, and a large sample of books and book chapters covered in the book citation index. Contrary to what is often suggested, we show that adding book and book chapter citations to journal citations does not produce significantly different rankings than those obtained solely on the basis of citations in journal articles.
Quartet-Based Computations of Internode Certainty Provide Robust Measures of Phylogenetic Incongruence
Authors: Zhou Xiaofan , Lutteropp Sarah , Czech Lucas , Stamatakis Alexandros , Looz Moritz Von , Rokas Antonis 
Published: August 2019

Abstract
Incongruence, or topological conflict, is prevalent in genome-scale data sets. Internode certainty (IC) and related measures were recently introduced to explicitly quantify the level of incongruence of a given internal branch among a set of phylogenetic trees and complement regular branch support measures (e.g., bootstrap, posterior probability) that instead assess the statistical confidence of inference. Since most phylogenomic studies contain data partitions (e.g., genes) with missing taxa and IC scores stem from the frequencies of bipartitions (or splits) on a set of trees, IC score calculation typically requires adjusting the frequencies of bipartitions from these partial gene trees. However, when the proportion of missing taxa is high, the scores yielded by current approaches that adjust bipartition frequencies in partial gene trees differ substantially from each other and tend to be overestimates. To overcome these issues, we developed three new IC measures based on the frequencies of quartets, which naturally apply to both complete and partial trees. Comparison of our new quartet-based measures to previous bipartition-based measures on simulated data shows that: (1) on complete data sets, both quartet-based and bipartition-based measures yield very similar IC scores; (2) IC scores of quartet-based measures on a given data set with and without missing taxa are more similar than the scores of bipartition-based measures; and (3) quartet-based measures are more robust to the absence of phylogenetic signal and errors in phylogenetic inference than bipartition-based measures. Additionally, the analysis of an empirical mammalian phylogenomic data set using our quartet-based measures reveals the presence of substantial levels of incongruence for numerous internal branches. An efficient open-source implementation of these quartet-based measures is freely available in the program QuartetScores (https://github.com/lutteropp/QuartetScores).
Inside the head of a cybertype – three-dimensional reconstruction of the head muscles of Ommatoiulus avatar (Diplopoda: Juliformia: Julidae) reveals insights into the feeding movements of Juliformia
Authors: Naumann Benjamin , Reip Hans S , Akkari Nesrine , Neubert David , Hammel Jörg U 
Published: August 2019

AbstractThe origin and diversification of the arthropod head is one of the major topics in the field of evolutionary morphology of Arthropoda. Among the major arthropod groups, Myriapoda and, more precisely Diplopoda, are generally poorly studied regarding their head anatomy. However, this group is of pivotal importance to understand the evolutionary functional morphology of the arthropod head. In this study, we investigate the complete musculoskeletal system of the diplopod head with a detailed description of the cephalic anatomy of the recently described species Ommatoiulus avatar. The comparison of our data with the literature on the few other species available show that the morphology of the musculoskeletal system within Juliformia, a subgroup of the Diplopoda, is relatively conservative. Using video recordings of the feeding movements in addition to the anatomical data, we revise the mechanism of the mandibular movements in Juliformia. There was a controversy whether mandibular abduction is an active process, facilitated by contraction of an abductor muscle, or if it is a passive process, mediated by tentorial and gnathochilarial movements not involving a direct abduction by muscular contraction. We show that mandibular abduction in Ommatoiulus is an active movement involving the contraction of an abductor muscle. This is similar to the mandibular abduction in other arthropod groups.
Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis
Authors: Bellin Melena D. , Lowe Mark , Zimmerman M. Bridget , Wilschanski Michael , Werlin Steven , Troendle David M. , Shah Uzma , Schwarzenberg Sarah J. , Pohl John F. , Perito Emily , Ooi Chee Yee , Nathan Jaimie D. , Morinville Veronique D. , McFerron Brian A. , Mascarenhas Maria R. , Maqbool Asim , Liu Quin , Lin Tom K. , Husain Sohail Z. , Himes Ryan , Heyman Melvin B. , Gonska Tanja , Giefer Matthew J. , Gariepy Cheryl E. , Freedman Steven D. , Fishman Douglas S. , Barth Bradley , Abu‐El‐Haija Maisam , Uc Aliye 
Published: August 2019

ABSTRACTObjectives:Adults with chronic pancreatitis (CP) have a high risk for developing pancreatogenic diabetes mellitus (DM), but little is known regarding potential risk factors for DM in children with acute recurrent pancreatitis (ARP) or CP. We compared demographic and clinical features of children with ARP or CP, with and without DM, in the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE) registry.Methods:We reviewed the INSPPIRE database for the presence or absence of physician‐diagnosed DM in 397 children, excluding those with total pancreatectomy with islet autotransplantation, enrolled from August 2012 to August 2017. Patient demographics, BMI percentile, age at disease onset, disease risk factors, disease burden, and treatments were compared between children with DM (n = 24) and without DM (n = 373).Results:Twenty‐four children (6% of the cohort) had a diagnosis of DM. Five of 13 tested were positive for beta cell autoantibodies. The DM group was 4.2 years [95% confidence interval (CI) 3–5.4] older at first episode of acute pancreatitis, and tended to more often have hypertriglyceridemia [odds ratio (OR) 5.21 (1.33–17.05)], coexisting autoimmune disease [OR 3.94 (0.88–13.65)] or pancreatic atrophy [OR 3.64 (1.13, 11.59)].Conclusion:Pancreatic atrophy may be more common among children with DM, suggesting more advanced exocrine disease. However, data in this exploratory cohort also suggest increased autoimmunity and hypertriglyceridemia in children with DM, suggesting that risk factors for type 1 and type 2 DM, respectively may play a role in mediating DM development in children with pancreatitis.
Serial Visual Evoked Potentials in Patients with Craniosynostosis and Invasive Intracranial Pressure Monitoring
Authors: Haredy Mostafa M. , Liasis Alki , Fu Valeria , Davis Amani , Pollack Ian F. , Losee Joseph E. , Saied Samia , Nischal Ken K. , Goldstein Jesse A. 
Published: August 2019

Summary:
This study aimed to detect the ability of pattern visual evoked potentials to detect visual pathway dysfunction in a cohort of patients with craniosynostosis who also had invasive intracranial pressure measurement. A retrospective review was conducted on craniosynostosis patients who had invasive intracranial pressure measurement and at least one pattern visual evoked potentials test. Reversal pattern visual evoked potentials were performed with both eyes open. Thirteen patients met the inclusion criteria (mean age at intracranial pressure measurement, 5.7 years). Seven patients had raised intracranial pressure, and of these, five (71.4 percent) had abnormal or deteriorated pattern visual evoked potentials parameters on serial testing, whereas all patients (100 percent) with normal intracranial pressure had normal pattern visual evoked potentials amplitude and latency. Four of the five patients (80 percent) with raised intracranial pressure and abnormal pattern visual evoked potentials did not show evidence of papilledema. The mean latency in patients with raised intracranial pressure (118.7 msec) was longer than in those with normal intracranial pressure (108.1 msec), although it did not reach statistical significance (p = 0.09), whereas the mean amplitude in patients with raised intracranial pressure (12.4 µV) was significantly lower than in patients with normal intracranial pressure (23.3 µV) (p = 0.03). The authors’ results showed that serial pattern visual evoked potentials testing was able to detect visual pathway dysfunction resulting from raised intracranial pressure in five of seven craniosynostosis patients, and of these five patients, 80 percent had no evidence of papilledema, demonstrating the utility of serial pattern visual evoked potentials in follow-up of the visual function in craniosynostosis patients.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Diagnostic, II.
Surgical Treatment of Lymphedema
Authors: Schaverien Mark V. , Coroneos Christopher J. 
Published: August 2019

Summary:Lymphedema affects up to 250 million people worldwide. The understanding of the pathophysiology of the condition, however, is incomplete and a cure remains elusive. A growing body of evidence supports the effectiveness of modern surgical techniques in ameliorating the long-term disability and functional impairment inflicted by lymphedema on the lives of those affected. These procedures can be broadly categorized as physiologic, including lymphovenous bypass and using a vascularized lymph node transplant; or de bulking, by suction-assisted lipectomy or direct excisional procedures. The lymphovenous bypass procedure involves identification of obstructed lymphatic vessels and targeted bypass of these into neighboring venules. The vascularized lymph node transplant procedure involves microvascular anastomosis of functional lymph nodes into an extremity, either to an anatomical (orthotopic) or nonanatomical (heterotopic) location, to restore physiologic lymphatic function. In patients undergoing postmastectomy breast reconstruction, this may be performed by transferring a deep inferior epigastric artery perforator flap with a chimeric groin lymph node flap. For patients that have undergone breast-conserving surgery, in those for whom a free abdominal flap is contraindicated, or for those with lymphedema affecting the lower extremity, many other vascularized lymph node transplant options are available; these include flaps harvested from within the axillary, inguinal, or cervical lymph node basins, or from within the abdominal cavity. Chronic lymphedema is characterized by fibroadipose soft-tissue deposition that can only be removed by lipectomy, either minimally invasively using liposuction, or by direct excision. This article reviews the techniques and outcomes of surgical procedures used to treat lymphedema.
Fine Particle Air Pollution and Physiological Reactivity to Social Stress in Adolescence: The Moderating Role of Anxiety and Depression
Authors: Miller Jonas G. , Gillette Julia S. , Manczak Erika M. , Kircanski Katharina , Gotlib Ian H. 
Published: August 2019

ABSTRACT

Objective
Exposure to high levels of fine particle air pollution (PM2.5) is associated with adolescent pathophysiology. It is unclear, however, if PM2.5 is associated with physiology within psychosocial contexts, such as social stress, and whether some adolescents are particularly vulnerable to PM2.5-related adverse effects. This study examined the association between PM2.5 and autonomic reactivity to social stress in adolescents and tested whether symptoms of anxiety and depression moderated this association.

Methods
Adolescents from Northern California (N = 144) participated in a modified Trier Social Stress Test while providing high-frequency heart rate variability and skin conductance level data. PM2.5 data were recorded from CalEnviroScreen. Adolescents reported on their own symptoms of anxiety and depression using the Youth Self-Report, which has been used in prior studies and has good psychometric properties (Cronbach’s α in this sample was .86).

Results
Adolescents residing in neighborhoods characterized by higher concentrations of PM2.5 demonstrated greater autonomic reactivity (i.e., indexed by lower heart rate variability and higher skin conductance level) (β = .27; b = .44, p = .001, 95% CI = 0.19 to 0.68) in response to social stress; this association was not accounted for by socioeconomic factors. In addition, adolescents who reported more severe anxiety and depression symptoms showed the strongest association between PM2.5 and autonomic reactivity to social stress (β = .53; b = .86, p < .001, 95% CI = 0.48 to 1.23).

Conclusions
Exposure to PM2.5 may heighten adolescent physiological reactivity to social stressors. Moreover, adolescents who experience anxiety and depression may be particularly vulnerable to the adverse effects of PM2.5 on stress reactivity.
Pressure Injury
Authors: Hajhosseini Babak , Longaker Michael T. , Gurtner Geoffrey C. 
Published: August 2019

Background:
Pressure injury is seen across all healthcare settings and affects people of any age and health condition. It imposes a significant burden, with annual costs of up to $17.8 billion in the United States alone. Despite considerable resources it exhausts, the disease remains very prevalent, and the incidence is on the rise. This is in part due to aging population, growing number of nursing home residents, poorly understood biology, and dismal track record of clinical research in this field.

Methods:
In our Review Article, we discuss the disease pathophysiology, clinical manifestation, evidence based recommendations for risk assessment, prevention and timely management, existing challenges, and directions to improve research on the field. This article encompasses dedicated sections on the full spectrum of the pressure related pathologies including “conventional pressure ulcers”, “medical device related pressure injuries”, “pressure injuries in mucosal membranes”, “pressure injuries in pediatric population”, “pressure injury at end of life”, and the “role of pressure in pathogenesis of diabetic foot ulcers”.
A Nationwide Population-based Study From Taiwan Assessing the Influence of Preventable Hospitalization Rate on Mortality After Oncologic Surgery
Authors: Kuo Chang-Fu , Kotsis Sandra V. , Wang Lu , Chen Jung-Sheng , Chung Kevin C. 
Published: August 2019

Objective:
To determine the effect of a previously unassessed measure of quality—preventable hospitalization rate—on mortality after oncologic surgery for 4 procedures with established volume–outcome relationships. We hypothesize that hospitals with higher preventable hospitalization rates (indicating poor quality of primary care) have increased hospital mortality. Additionally, patients having surgery at hospitals with higher preventable hospitalization rates have increased mortality.

Summary Background Data:
Although different factors have been used to measure healthcare quality, most have not resulted in long-term hospital-based improvements in patient outcomes.

Methods:
We retrieved data from Taiwan's National Health Insurance database for patients who underwent surgery during 2001 to 2014 for esophagectomy, pancreatectomy, lung resection, or cystectomy. Preventable hospitalization rates assess hospitalizations for 11 chronic conditions that are deemed to be preventable with effective primary care. The outcome was 30-day surgical mortality. Identifiable factors potentially related to surgical mortality, including surgeon and hospital volume, were controlled for in the models.

Results:
Our dataset contained 35,081 patients who had surgery for one of the procedures. For all procedures, hospitals with high preventable hospitalization rates were associated with higher mortality rates (all P < 0.01). For esophagectomy, lung resection, and cystectomy, the adjusted odds of individual mortality increased by 8% to 10% (P < 0.01) for every 1% increase in the preventable hospitalization rate. For pancreatectomy, the adjusted odds of individual mortality increased by 21% for every 1% increase in preventable hospitalization rate when the rate was ≥8% (P < 0.01).

Conclusions:
Preventable hospitalization rates could serve as warning signs of low quality of care and be a publically-reported quality measure.