bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macro-CK type 2 in metastatic prostate cancer
Authors: Eidizadeh Abass , von Ahsen Nicolas , Friedewald Steffen , Binder Lutz 
Published: November 2018

Abstract
The isoenzyme creatine kinase muscle/brain (CK-MB) still plays an important role for the differential diagnosis of CK elevations and the clarification of their origin from heart or skeletal muscle. Therefore, it is necessary to know the diagnostic pitfalls in interpreting CK-MB results. We demonstrate a case of macro-CK type 2 in a 75-year-old patient with metastatic castration-resistant prostate cancer and its identification by isoenzyme electrophoresis, which can be typical for cancer diseases.
Crystal structure of oxidobis(piperidine-1-carbodithioato-κ2
S,S′)vanadium(IV), C12H20N2OS4V
Authors: Machálková Aneta , Charamzová Iva , Honzíček Jan , Vinklárek Jaromír , Císařová Ivana 
Published: November 2018

Abstract
C12H20N2OS4V, triclinic, P1̄ (no. 2), a = 7.0892(2) Å, b = 8.8797(2) Å, c = 13.8486(3) Å, α = 87.1010(10)°, β = 82.3160(10)°, γ = 71.4110(10)°, V = 818.84(3) Å3, Z = 2, R
gt(F) = 0.0249, wR
ref(F
2) = 0.0707, T = 150(2) K.
The crystal structure of trans-dichlorido-bis(pyridine-2-carboxylato-κ2
N,O)platinum(IV), C12H8Cl2N2O4Pt
Authors: Ha Kwang 
Published: November 2018

Abstract
C12H8Cl2N2O4Pt, triclinic, P1̄ (no. 2), a = 6.6940(3) Å, b = 9.5552(6) Å, c = 10.7954(6) Å, α = 83.8311(19)°, β = 88.1577(16)°, γ = 86.8053(17)°, V = 685.20(7) Å3, Z = 2, R
gt(F) = 0.0244, wR
ref(F
2) = 0.0601, T = 223(2) K.
The crystal structure of N,N′-(6-(thiophen-2-yl)-1,3,5-triazine-2,4-diyl)bis(2-methylpropane-2-sulfonamide) – ethyl acetate(2/1), C34H54N10O6S6
Authors: Zuo Zhenyu , Yan Hao , Song Xiao , Song XiaoMei , Guo Dongyan 
Published: November 2018

Abstract
C34H54N10O6S6, monoclinic, P21 (no. 4), a = 11.8434(5) Å, b = 11.2298(6) Å, c = 17.0706(8) Å, β = 94.661(2)°, V = 2262.86(19) Å3, Z = 4, R
gt(F) = 0.0287, wR
ref(F
2) = 0.0809, T = 150(2) K.
New light on neurotransmitter-gated receptors: Optical approaches for controlling physiological function
Authors: Reiner Andreas 
Published: November 2018

Abstract
Neurotransmitter-gated receptors contribute to synaptic transmission and modulation in many ways. Considering glutamate receptors as an example, it becomes clear that these receptor families are highly diverse and that it is experimentally challenging to disentangle the different functional contributions of closely related receptor subtypes. Pharmacological and genetic methods are now complemented by optogenetic approaches, which allow for controlling receptor signaling with light. Using glutamate receptors as an example, I summarize how tethered photoswitchable ligands can be used to control individual receptor subtypes with high spatial and temporal precision, and in specific cells. These, and similarly exciting approaches, offer new possibilities for probing the function of individual receptors in the nervous system.
See what you hear – How the brain forms representations across the senses
Authors: Noppeney Uta , Jones Samuel A. , Rohe Tim , Ferrari Ambra 
Published: November 2018

Abstarct
Our senses are constantly bombarded with a myriad of signals. To make sense of this cacophony, the brain needs to integrate signals emanating from a common source, but segregate signals originating from the different sources. Thus, multisensory perception relies critically on inferring the world’s causal structure (i. e. one common vs. multiple independent sources). Behavioural research has shown that the brain arbitrates between sensory integration and segregation consistent with the principles of Bayesian Causal Inference. At the neural level, recent functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) studies have shown that the brain accomplishes Bayesian Causal Inference by dynamically encoding multiple perceptual estimates across the sensory processing hierarchies. Only at the top of the hierarchy in anterior parietal cortices did the brain form perceptual estimates that take into account the observer’s uncertainty about the world’s causal structure consistent with Bayesian Causal Inference.
The Transfer Characteristics of Hair Cells Encoding Mechanical Stimuli in the Lateral Line of Zebrafish
Authors: Pichler Paul , Lagnado Leon 
Published: November 2018

Hair cells transmit mechanical information by converting deflection of the hair bundle into synaptic release of glutamate. We have investigated this process in the lateral line of larval zebrafish (male and female) to understand how stimuli are encoded within a neuromast. Using multiphoton microscopyin vivo, we imaged synaptic release of glutamate using the reporter iGluSnFR as well as deflections of the cupula. We found that the neuromast is composed of a functionally diverse population of hair cells. Half the hair cells signaled cupula motion in both directions from rest, either by increasing glutamate release in response to a deflection in the positive direction or by reducing release in the negative direction. The relationship between cupula deflection and glutamate release demonstrated maximum sensitivity at displacements of just ∼40 nm in the positive direction. The remaining hair cells only signaled motion in one direction and were less sensitive, extending the operating range of the neuromast beyond 1 μm. Adaptation of the synaptic output was also heterogeneous, with some hair cells generating sustained glutamate release in response to a steady deflection of the cupula and others generating transient outputs. Finally, a distinct signal encoded a return of the cupula to rest: a large and transient burst of glutamate release from hair cells unresponsive to the initial stimulus. A population of hair cells with these different sensitivities, operating ranges, and adaptive properties will allow the neuromast to encode weak stimuli while maintaining the dynamic range to signal the amplitude and duration of stronger deflections.SIGNIFICANCE STATEMENTHair cells transmit information about mechanical stimuli by converting very small deflections of their hair bundle into changes in the release of the neurotransmitter glutamate. We have measured this input/output relation in the live fish using a fluorescent protein and find that different hair cells vary in their mechanical sensitivity and the time course of their response. These variations will allow the fish to sense the timing and duration of both very weak stimuli (∼40 nm deflections) and strong stimuli (∼1 μm), underlying the ability of the fish to avoid predators and maintain its body position in flowing water.
Heterochromatin-Enriched Assemblies Reveal the Sequence and Organization of theDrosophila melanogasterY Chromosome
Authors: Chang Ching-Ho , Larracuente Amanda M 
Published: November 2018

AbstractHeterochromatic repeat-rich regions are often missing from even the best genome assemblies. Chang and Larracuente designed a de novo assembly strategy to improve the Drosophila melanogaster assembly in heterochromatin, extending the reference assembly by 11.9 Mb, including 10.6 Mb from the Y chromosome.....Heterochromatic regions of the genome are repeat-rich and poor in protein coding genes, and are therefore underrepresented in even the best genome assemblies. One of the most difficult regions of the genome to assemble are sex-limited chromosomes. The Drosophila melanogaster Y chromosome is entirely heterochromatic, yet has wide-ranging effects on male fertility, fitness, and genome-wide gene expression. The genetic basis of this phenotypic variation is difficult to study, in part because we do not know the detailed organization of the Y chromosome. To study Y chromosome organization in D. melanogaster, we develop an assembly strategy involving the in silico enrichment of heterochromatic long single-molecule reads and use these reads to create targeted de novo assemblies of heterochromatic sequences. We assigned contigs to the Y chromosome using Illumina reads to identify male-specific sequences. Our pipeline extends the D. melanogaster reference genome by 11.9 Mb, closes 43.8% of the gaps, and improves overall contiguity. The addition of 10.6 MB of Y-linked sequence permitted us to study the organization of repeats and genes along the Y chromosome. We detected a high rate of duplication to the pericentric regions of the Y chromosome from other regions in the genome. Most of these duplicated genes exist in multiple copies. We detail the evolutionary history of one sex-linked gene family, crystal-Stellate. While the Y chromosome does not undergo crossing over, we observed high gene conversion rates within and between members of the crystal-Stellate gene family, Su(Ste), and PCKR, compared to genome-wide estimates. Our results suggest that gene conversion and gene duplication play an important role in the evolution of Y-linked genes.
Repercussões para a família que acompanha um paciente em cuidados paliativos
Authors: Faro Carolina Lomanto , Castro Maria Luiza Sarno 
Published: November 2018

Os cuidados paliativos surgem como uma mudança de paradigma na assistência ao paciente que se encontra fora de possibilidades terapêuticas, a fim de aliviar a dor e o sofrimento desse indivíduo. O presente artigo tem como objetivo compreender o que a literatura traz sobre os principais impactos que repercutem na família que acompanha um paciente diante da impossibilidade terapêutica, relatando os sentimentos e os processos vivenciados por esse núcleo, considerando as publicações brasileiras que existem sobre esse assunto. O estudo trata-se de uma revisão sistemática realizada a partir de artigos já existentes nas bases de dados da Biblioteca Virtual de Saúde – Scielo, Lilacs e Pepsic,. O período selecionado dos artigos contemplou os anos de 2012 a 2016 e aborda os descritores: cuidados paliativos e família. Foram analisadas 15 publicações existentes e identificadas as categorias: as singularidades do cuidar no domicílio/ hospital, sentimento e sensações vivenciados pelo cuidador, dificuldades inerentes ao cuidar e fontes de apoio do cuidador. Tais categorias possibilitaram compreender que quando um dos membros do núcleo familiar depara-se com um doença fora de possibilidades terapêuticas é necessário um rearranjo nesse sistema. Além disso, diante da terminalidade, muitas vezes, um cuidador se torna responsável pelo paciente, sofrendo os impactos inerentes ao cuidar, contribuindo assim para o debate acerca dos cuidados paliativos e a atenção dada ao familiar que assume a função de cuidador.
Modular Visualization of Distributed Systems
Authors: Guevara Gustavo , Desell Travis , LaPorte Jason , Varela Carlos A. 
Published: November 2018

Effective visualization is critical to developing, analyzing, and optimizing distributed systems. We havedeveloped OverView, a tool for online/offline distributed systems visualization, that enables modular layout mechanisms, so that different distributed system high-level programming abstractions such as actors or processes can be visualized in intuitive ways. OverView uses by default a hierarchical concentric layout that distinguishes entities from containers allowing migration patterns triggered by adaptive middleware to be visualized. In this paper, we develop a force-directed layout strategy that connects entities according to their communication patterns in order to directly exhibit the application communication topologies. In force-directed visualization, entities`' locations are encoded with different colors to illustrate load balancing. We compare these layouts using quantitative metrics including communication to entity ratio, applied on common distributed application topologies. We conclude that modular visualization is necessary to effectively visualize distributed systems since no one layout is best for all applications.
Modern low-molecular-weight heparins in the prevention and treatment of venous thromboembolic complications in oncourologic patients
Authors: Vorobyev N. V. , Popov S. V. 
Published: November 2018

Oncourologic diseases are accompanied by a risk for subsequent venous thromboembolic complications, which are rated the most dangerous in terms of thrombogenic effect. The article presents a review of the clinical studies of efficacy and safety, and the experience in using of modern low-molecular-weight heparins in clinical practice - drugs of choice for the prevention of venous thromboembolic complications in cancer patients. Particular attention is paid to Bemiparin - a new second-generation low-molecular-weight heparin with a significant antithrombotic effect and improved pharmacological parameters that allow it to be successfully used in patients with impaired renal function in oncourological practice.
Withdrawal Notice: Big Data Opportunities in the Telecommunication Sector: A Case Study of a Moroccan Mobile Networks Operator
Authors: Daki Houda , Elhannani Asmaa , Aqqal Abdelhak , Haidine Abdelfattah , Dahbi Aziz 
Published: November 2018

The article has been withdrawn at the request of the authors and editor of the journal Recent Advances in Computer Science
and Communications.;

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:
It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
El papel de la confianza en proyectos de innovación colaborativa. Propuesta teórico-metodológica
Authors: Pino García Gabriela , Aguilar Barajas Ismael , Ayala Gaytán Edgardo Arturo 
Published: November 2018

Este artículo aborda el papel de la confianza en la generación de innovación colaborativa. Se analizan las metodologías de investigación, antecedentes, temporalidad y conceptualización de la confianza. Lo anterior se enlaza con sus dimensiones y formas de operacionalización que se han utilizado en diferentes contextos para entender la innovación colaborativa. Se desarrolla un modelo teórico-metodológico para explicar la construcción de la confianza en proyectos de innovación, como un proceso complejo y costoso. El modelo puede ser aplicado en distintos ámbitos, incluido el territorial, por ejemplo, en la evaluación de los sistemas de innovación regionales.
Мінеральна щільність кісткової тканини, жирова та знежирена маса у пацієнтів, які перенесли мозковий інсульт
Authors: Bystrytska M.А. 
Published: November 2018

Актуальність. Мозковий інсульт (МІ) та остеопороз — вік­залежні патології, що вражають переважно осіб літнього віку. Метою дослідження було вивчення мінеральної щільності кісткової тканини (МЩКТ), жирової, знежиреної маси та зв’язку між ними в пацієнтів, які перенесли МІ. Матеріали та методи. Було обстежено 84 пацієнти, які перенесли інсульт, та 124 особи відповідного віку та статі без неврологічної патології, які становили групу порівняння. МЩКТ, показники знежиреної та жирової маси визначали за допомогою двофотонної рентгенівської абсорбціометрії. Результати. У чоловіків і жінок, які перенесли МІ, частота остеопорозу була вірогідно вищою, ніж у осіб групи порівняння (12,5 та 1,7 %, 20,5 та 6,0 % відповідно). МЩКТ у жінок після інсульту була вірогідно нижче на рівні всіх обстежених ділянок, у чоловіків відмінності зареєстровані на рівні дистального відділу кісток передпліччя та всього скелета. У чоловіків, які перенесли МІ, виявлено вірогідно нижчі показники знежиреної маси (54,29 ± 1,22 кг та 58,02 ± 0,85 кг; р < 0,05), а у жінок — вірогідно нижчі показники жирової маси як у відсотках (41,96 ± 1,06 % і 44,84 ± 0,59 %; р < 0,05), так і в абсолютних цифрах (32,42 ± 1,92 кг та 36,71 ± 1,15 кг; р < 0,05). У чоловіків обох груп виявлено вірогідно позитивні зв’язки між МЩКТ всього скелета та показниками знежиреної маси. У жінок із МІ зареєстровано позитивні зв’язки помірної сили між показниками знежиреної маси та МЩКТ шийки стегнової кістки, верхніх кінцівок і всього скелета. А також, на відміну від чоловіків, зареєстровано вірогідні зв’язки жирової маси з МЩКТ всіх обстежених регіонів скелета. Висновки. Результати нашого дослідження показують, що МІ є фактором ризику розвитку остеопорозу і підкреслюють роль жирової та знежиреної маси в генезі остеопорозу у пацієнтів, які перенесли інсульт.
Епідеміологічні та соціально-економічні особливості інфаркту міокарда та інсульту у хворих на цукровий діабет 2-го типу
Authors: Krushinska Z.G. , Yuzvenko T.Yu. , Pankiv V.I. 
Published: November 2018

Мета. Вивчення епідеміологічних та соціально-економічних особливостей інфаркту міокарда (ІМ) та інсульту у хворих на цукровий діабет (ЦД) 2-го типу. Матеріали та методи. Пацієнти були розподілені на 3 групи: першу групу становили всі хворі на ЦД, які взяли участь у дослідженні (n = 1999), другу групу — хворі (n = 201) на ЦД із першої групи з ІМ, третю групу — хворі на ЦД із першої групи з інсультом (n = 155). Результати. Встановлено суттєві відмінності між частотою ЦД і частотою ІМ та інсульту у цих хворих залежно від статі пацієнта. Середній вік хворих на ЦД з ІМ та інсультом вище порівняно із загальною популяцією хворих на ЦД. Переважну більшість пацієнтів становлять соціально не захищені верстви населення, які не мають фінансової змоги отримувати медичну допомогу, зокрема терапію, адекватну їх стану, наявним ускладненням і супутній патології. Висновки. Повторний ІМ зареєстровано у 3 % хворих на ЦД, більше ніж утричі частіше за повторний ІМ траплявся повторний інсульт (9,7 %), при цьому вдвічі частіше — у жінок (12,2 проти 6,2 % у чоловіків). Частка хворих на ІМ серед хворих на інсульт удвічі вища за аналогічний показник серед усіх хворих на ЦД (20,7 та 10,1 % відповідно).
DAVIDSON Y EL HORIZONTE PRAGMÁTICO: DISOLUCIÓN DEL BINOMIO "ESQUEMA-CONTENIDO"
Authors: Hernández David Martín 
Published: November 2018

El objetivo de las siguientes páginas consiste en mostrar la importancia de la reducción del binomio "esquema-contenido"; proceso que representa una continuación de la naturalización de la semántica iniciada, por un lado, en Wittgenstein con la propuesta de revisión de la diferencia cualitativa entre juicios analíticos y sintéticos, y perfecionada, por el otro, por Quine con la cancelación de cualquier distancia entre ambos. Para el alemán, trasrenunciar a las tesis formuladas en su Tractatus, la separación entre ambos resulta meramente cuantitativa, eliminando así, la prioridad ontológica de unos respecto a otros. El americano, sin embargo, propondrá la supresión de tales categorías, afirmando rotundamente que no existe lo analítico ni lo sintético. Aún así, mantendrá la necesidad del esquema -lenguaje- separado del contenido -mundo-, implicando el abandono al relativismo y la incomposibilidad significativa entre lenguajes diferentes. Davidson mostrará que la naturalización del esquema, colegido de la eliminación del primer dogma, abre las puertas a situaciones comunicativas entre agentes con procedencias y biografías radicalmente diferentes, constituyendo la apertura a ese proceso de pragmatización del lenguaje.
On The Value Implied In The Data Referred To In The Mahābhārata for π
Authors: Jadhav Dipak 
Published: November 2018

<p>E. Washburn Hopkins interpreted, in 1902, the values for from the data referred to in some verses contained in the <em>Bhīṣma Parva</em> of the <em>Mahābhārata</em> where is a non-terminating and non-recurring fixed ratio of the circumference, , of a circle to its diameter, . The values interpreted for it by him from the data referred to for the dimensions, including , , and <em>vipulatva</em> , of the Rāhu, the Moon, and the Sun are 3.5, 3.5+, and 3.58 respectively. R. C. Gupta found, in 1990, these values to be the yielding of the gross misinterpretations. He pointed out that the value implied in the data of each of the three cases is only 3. The present paper is mainly aimed at probing when and why 3 was used in the <em>Mahābhārata</em> as the value for . The date when those above verses were incorporated in the <em>Mahābhārata</em> is the one when 3 as the value for<em> </em> was used in the same if consistency is preferred to as a sound criterion in determining so. It tends to 500 BCE in its range extending from 500 BCE to 500 CE. It may go even beyond 500 BCE. 3 as the value for<em> </em> seems to have been borrowed from some older forms of the <em>Purāṇas</em> into the <em>Mahābhārata</em>. If simplicity, prevalence, and traditionalism are preferred to as a sound criterion to calculate for a given , no other option for is better than 3. The support for this option was available not only in the interior of India right from the <em>Ṛgveda</em> but also in the exterior of India at least right from the old Babylonian text.</p>
Religion In The Adolescents’ Point Of View: The subjectivism perspective by søren a. Kierkegaard
Authors: Marsono . 
Published: November 2018

<p>The specific characteristic of the adolescents is their existential. It means that the adolescent’s involvement in term of thought and their era’s situation are closely related to the development of the adolescence itself in the transition from childhood to adolescence. In this transition process, the adolescents have to be able to put their existence between the social transformation and the demand to be mature which come from their social environment. This perspective makes them to be something that is interested to be discussed. This writing will try to give a kind of description about the involvement of adolescents in reading and interpreting their religions in the point of view of Søren Kierkegaard’s subjectivism. The discussion will focus on the diversity elements of the adolescents which are closely related to the subjectivity. This aims to describe the characteristics and intensity of the diversity‘s struggle faced by the adolescents which is more existential.</p>