bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful of SK305 Artificial Reefing Decommissioning Project
Authors: Sulaiman Mohd Zhafran , Ros Mohamad Ikhranizam , Azizan Mohd Azwan 
Published: November 2018

Abstract
This paper will discuss on recent SK305 decommissioning project which had completed in November 2017. These two platforms had been total removal and been an artificial reef at Sarawak water in Malaysia. This paper will share on activity and best practices from early stage until completion which divided into phases Engineering, Preparation, Removal and Disposal and Post Decommissioning /Reefing activity. Preparation activities needed for decommissioning and reefing project start with Baseline survey at reef location, underwater inspection, and topside inspection. During the Engineering stage, facilities integrity checks, removal engineering and Transportation engineering been carried out. Cutting basis and cutting equipment been developed and identified. Performed reefing engineering to ensure lowering of the facilities is in control condition and reefed facilities are stable. Topside and jacket removal via single lifting accordingly been execute follows the procedure and engineering for smooth execution. Post decommissioning survey been carried out to assess the successful of the project. Baseline inspection, underwater inspection had provided some information to the contractor on the scope and reveal some of the uncertainties about the decommissioning project. Engineering study is critical when to ensure safe operation. Observed that actual operation is similar to the engineering's simulation where team had follow the engineering accordingly. Reefing engineering performed to ensure the facilities been placed at the right location and position. During offshore execution removal of facilities there are challenges we faced malfunction of the cutting/dredge equipment had led to use back up plan and innovative solution to utilized other available equipment available onboard (Diamond wire cutter, abrasive water jet internal cutter, dredger, soil plug removal, airlift, cutting torch etc.). Sequence of cutting also need to be consider to minimize the pinch effect of the facilities. Decommissioning Safety Case been developed for this project to registered and to close the remedial action plan which will help project not to oversight any critical activity and aspect that had been identified. Finally, the post decom/reefing survey had been carried and the result observed new marine growth and numbers of fishes at reefed platform and had concluded the successful of this decommissioning reefing project. This paper should be an interest to those who will exploring abandonment and decommissioning project which considering reefing as one of the decommissioning option. This paper will share on it process on materializing reefing of 2 platforms through Engineering, Preparation, Removal and Disposal (EPRD) approach contract. The novelty in this paper is on assurance that been made by Company via baseline and post reefing survey to ensure environment aspect been consider.
One-year Outcome of Shanghai Mild Cognitive Impairment Cohort Study
Authors: Zhou Bin , Zhao Qianhua , Kojima Shinsuke , Ding Ding , Higashide Satoshi , Nagai Yoji , Guo Qihao , Kagimura Tatsuo , Fukushima Masanori , Hong Zhen 
Published: November 2018

Background & Objective: The purpose of this study is to identify the risk factors associated with the conversion from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease (AD) dementia for the early detection of AD.Methods:The study comprised a prospective cohort study that included 400 MCI subjects with annual follow-ups for 3 years.Results:During the first 12 months’ follow-up, 42 subjects converted to Alzheimer’s dementia (21 probable AD and 21 possible AD), two subjects converted to other types of dementia and 56 subjects lost follow. The factors associated with a greater risk of conversion from MCI to AD included gender, whole brain volume, and right hippocampal volume (rt. HV), as well as scores on the Revised Chinese version of the Alzheimer’s Disease Assessment Scale-Cognitive subscale 13 (ADAS-Cog-C), Clock Drawing Test (CDT), Symbol Digit Modalities Test (SDMT), and Rey-Osterrieth Complex Figure Test (ROCFT). The risk classification of the combined ADAS-Cog-C and Alzheimer Cognitive Composite (ACC) score with the rt. HV and left Entorhinal Cortex Volume (lt. ECV) showed a conversion difference among the groups.Conclusion:Early detection of AD and potential selection for clinical trial design should utilize the rt. HV, as well as neuropsychological test scores, including those of the ADAS-Cog-C and ACC.
Synthesis and Evaluation of in vitro Antiplatelet Aggregation Activities of 2-Methoxy-5-Aminobenzamides
Authors: Liu Lili , Liu Xiujie , Chen Guangling , Qiu Kai 
Published: November 2018

Objective:
According to the principles of drug design, the structures of picotamide and
betrixaban were combined to design novel series of 2-methoxy-5-aminobenzamides. A total of
twenty new compounds 1a-1t have been synthesized and evaluated for their antiplatelet aggregation
activities in vitro.

Methods:
In the structural design of target compounds 1a-1t, the betrixaban was retained group
characteristics and the picotamide was retained its 1, 3, 4-substitution position. With
2-methoxybenzoic acid as starting material, compounds 1a-1t were synthesized after 5 steps of nitration,
acylation, ammoniation, reduction and secondary ammoniation. And their antiplatelet aggregation
activities in vitro were assessed by the Born test with ADP, arachidonic acid and collagen as
inducing agents, respectively, and with aspirin and picotamide as two reference drugs.

Results:
The compound 1f (46.14%±0.07) had the highest activity for ADP and its IC50 value was
0.17 µM, far better than the two control drugs aspirin (0.44 µM) and picotamide (0.47 µM). The IC50
value of four compounds 1i (0.24 µM), 1j (0.22 µM), 1r (0.25 µM) and 1t (0.24 µM), displayed
higher antiplatelet activities in vitro for AA than aspirin (0.43 µM) and picotamide (0.34 µM).
Evaluation of cytotoxicity activity of the compounds against L929 cells line revealed that at lower
concentration of 10 µmol·L-1, compound 1p had lower effect on L929 cells, and its cell survival rate
(88.24%±4.16) was higher than that (82.35%±4.16) of picotamide.

Conclusion:
Novel series of 2-methoxy-5-aminobenzamides has shown higher in vitro antiplatelet
activities and lower effect on L929 cells at lower concentration.
Exhaustive Review on Lung Cancers: Novel Technologies
Authors: Khan Sajad , Ali Shahid , Muhammad  
Published: November 2018

Background:Lung cancers or (Bronchogenic-Carcinomas) are the disease in certain parts of the lungs in which irresistible multiplication of abnormal cells leads to the inception of a tumor. Lung cancers consisting of two substantial forms based on the microscopic appearance of tumor cells are: Non-Small-Cell-Lung-Cancer (NSCLC) (80 to 85%) and Small-Cell-Lung-Cancer (SCLC) (15 to 20%).Discussion:Lung cancers are existing luxuriantly across the globe and the most prominent cause of death in advanced countries (USA & UK). There are many causes of lung cancers in which the utmost imperative aspect is the cigarette smoking. During the early stage, there is no perspicuous sign/symptoms but later many symptoms emerge in the infected individual such as insomnia, headache, pain, loss of appetite, fatigue, coughing etc. Lung cancers can be diagnosed in many ways, such as history, physical examination, chest X-rays and biopsy. However, after the diagnosis and confirmation of lung carcinoma, various treatment approaches are existing for curing of cancer in different stages such as surgery, radiation therapy, chemotherapy, and immune therapy. Currently, novel techniques merged that revealed advancements in detection and curing of lung cancer in which mainly includes: microarray analysis, gene expression profiling.Conclusion:Consequently, the purpose of the current analysis is to specify and epitomize the novel literature pertaining to the development of cancerous cells in different parts of the lung, various preeminent approaches of prevention, efficient diagnostic procedure, and treatments along with novel technologies for inhibition of cancerous cell growth in advance stages.
Phytochemical Profiling, GC-MS Analysis and α-Amylase Inhibitory Potential of Ethanolic Extract ofCocos nuciferaLinn. Endocarp
Authors: Singla Rajeev Kumar , Dubey Ashok Kumar 
Published: November 2018

Background:Drugs with post-prandial action constitute one of the main courses of treatments for diabetes.Objective:In the present investigation, we have explored the α-amylase inhibitory potential of ethanolic extract of Cocos nucifera endocarp.Methods:DNS based assay was done to assess the α-amylase inhibition potential of ethanolic extract. Phytochemical screening and GC-MS analysis were done in order to assess the chemical profiling of extract. In silico docking studies were done using VLife MDS 4.6 software and the probable molecules, predicted after GC-MS analysis, were docked with the co-crystallized (acarbose) tracked active site and rest all cavities of porcine pancreatic α-amylase (1OSE). ADMET analysis was done using StarDrop 6.4, Derek Nexus and P450 Modules from Optibrium Ltd. and LHASA Ltd.Results:DNS based α-amylase assay indicated that the IC50 value of extract lies in the range of 63- 126 µg/ml and at higher doses, i.e. above 250 µg/ml, it has better α-amylase inhibition than the standard drug, acarbose. Phytochemical screening indicated that ethanolic extract is rich in alkaloids, tannins, flavonoids, saponins, triterpenes, glycosides, carbohydrates, terpenoids, quinones and lactones. Further, GC-MS analysis (where Similarity Index was > 90) predicted that the probable phytoconstituents present in the ethanolic extract are myristic acid, syringaldehyde, eugenol, vanillin, 2,4-di-tert-butylphenol, lauric acid, palmitic acid methyl ester and γ-sitosterol. γ-Sitosterol showed the strong affinity towards the active site which was tracked by a co-crystallized ligand along with cavity 1 and 2 while significant interactions were observed in case of co-crystallized tracked active site as well as cavity 4 of 1OSE. Ethanolic extract of C. nucifera has no hemolytic effect.Conclusion:Its ability to effectively inhibit α-amylase may be attributed to the presence of the above probable molecules, which will be explored furthe
Plant-derived Glycosides with α-Glucosidase Inhibitory Activity: Current Standing and Future Prospects
Authors: Khan Haroon , Amin Surrya , Tewari Devesh , Nabavi Seyed Mohammad , Atanasov Atanas G. 
Published: November 2018

Background:The α-glucosidase (EC 3.2.1.20), a calcium-containing intestinal enzyme which is positioned in the cells which cover the intestinal microvilli brush border. The carbohydrates require metabolism by α-glucosidase before being absorbed into the small intestine, and as a result, this enzyme represents a significant drug target for the effective management of diabetes. There are few α- glucosidase inhibitors in the clinical practice that is challenged by several limitations. Thus, new effective and safe therapeutic agents in this class are required. In this regard, plant secondary metabolites are a very promising source to be investigated. Herein in this review, we have focused on the preclinical studies on various glycosides with in vitro α-glucosidase inhibitory activity.Methods:The literature available on various websites such as GoogleScholar, PubMed, Scopus. All the peer-reviewed articles were included without considering the impact factor.Results:The surveyed literature revealed marked inhibitory profile of various glycosides derived from plants, and some of them were extremely potent relatively to the standard, acarbose in preclinical trials and exhibited multiple targeted effects.Conclusion:Keeping in view the results, these glycosides are strong candidates for further, more detailed studies to ascertain their clinical potential and for effective contribution in effective management of diabetes, where multiple targets are required to address
The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome
Authors: Dikci Seyhan , Öztürk Emrah , Fırat Penpe G. , Yılmaz Turgut , Taşkapan Mehmet Ç. , Yoloğlu Saim 
Published: November 2018

Objective: To investigate whether serum vitamin D levels have an effect on
pseudoexfoliation (PEX) glaucoma/syndrome development and on the control of glaucoma in these
cases.
</P><P>
Method: A total of 31 cases with PEX glaucoma, 34 cases with the PEX syndrome and 43 control
subjects of similar age and sex were included in the study. Vitamin D levels were compared between
the groups and also between the cases where glaucoma surgery was performed or not.

Results:
PEX glaucoma group consisted of 17 males and 14 females, PEX syndrome group of 27
males and 7 females, and the control group of 27 males and 16 females. The mean age was 70.9±8.9
years, 72.1±7.3 years, and 67.9±9.1 years in PEX glaucoma, syndrome and control group, respectively.
Mean vitamin D levels were 9.4±7.7 ng/mL, 7.9±6,1 ng/mL, 11.5±14.2 ng/mL in PEX glaucoma, syndrome
and control group, respectively (p>0.05). The mean serum vitamin D level was 8.04±4.7 ng/mL
in those who underwent glaucoma surgery and 10.1±8.7 ng/mL in those who didn't undergo glaucoma
surgery in PEX glaucoma group (p>0.05). No difference was found between the PEX glaucoma subgroups
in terms of the mean deviation when classified according to vitamin D levels (<10 ng/mL, ≥10
ng/mL) (p>0.05).

Conclusion:
Although we found no statistically significant difference between the PEX syndrome/
glaucoma, and control group in terms of serum vitamin D levels, serum vitamin D levels were
lower in PEX syndrome and glaucoma group than control group. Our results indicate that serum vitamin
D levels have no effect on the development of PEX glaucoma/syndrome or the control of the disorder
in cases with PEX glaucoma. However, these results need to be supported with further studies on
a larger number of patients and with longer follow-up.
The Influence of Cold Atmospheric Plasma Irradiation on the Adhesive Bond Strength in Non-Demineralized and Demineralized Human Dentin: An In Vitro Study
Authors: Imiolczyk Sandra Maria , Hertel Moritz , Hase Isabella , Paris Sebastian , Blunck Uwe , Hartwig Stefan , Preissner Saskia 
Published: November 2018

Purpose:
While aiming at the use of Cold Atmospheric Plasmas (CAPs) in restorative dentistry, the present study intended to assess if plasma irradiation increases the Tensile Bond Strength (TBS) in non-demineralized and demineralized dentin.

Materials and Methods:
Forty-eight human dentin samples were assigned to three different treatment modalities: I: Plasma jet irradiation (CAP I); II: Dielectric barrier discharge plasma treatment (CAP II); and III: No plasma (control). In each group, half of the specimens had previously been demineralized. A fourth generation of adhesive and dental composite was applied to all of the samples. The testing of the TBS was performed after artificial aging.

Results:
In the non-demineralized dentin, the mean TBS values were significantly higher after using CAP II (16.95 MPa) than in the control samples (4.2 MPa; p = 0.001). Significantly higher TBS values were also obtained after irradiating the demineralized dentin with CAP I and CAP II (11.68 and 4.6 MPa) when compared to the control samples (0 MPa; p = 0.003 and 0.038). The differences between both of the plasma sources were only slightly significant (p = 0.05).

Conclusion:
CAPs can potentially enhance the adhesive/dentin interfacial bonding strength, whereby the underlying effects seem to depend on the type of plasma source and the degree of dentinal (de-) mineralization. In the non-demineralized dentin, after a complete caries excavation, dielectric barrier discharge devices might be favorable over the plasma jets, in order to improve the adhesive/dentin interfacial bonding. In contrast, the plasma jets could be more effective in the demineralized dentin after an incomplete caries excavation.
Two-axis Gimbal System Stabilization Using Adaptive Feedback Linearization
Authors: Naderolasli Amir , Tabatabaei Mohammad 
Published: November 2018

Background:
This paper is devoted to adaptive feedback linearization based stabilization
of a two-axis gimbal platform.

Methods:
A Lyapunov based adaptation mechanism is proposed for stabilization of a two axes gimbal
system through a feedback linearized control structure. The uncertainty of the products of inertia
is incorporated in the design procedure.

Results:
The performed computer simulations demonstrate the robust performance of the proposed
two-axis gimbal stabilizer considering the cross-coupling effects between inner and outer gimbals.

Conclusion:
The proposed control structure could be utilized in guided missiles, spacecraft, and
navigation systems.
The Impact of Marine Tourism Towards the Local Community at Pulau Pangkor, Perak
Authors: Sulaiman Firdaus Chek , Jaini Norajlin , Jamaluddin Ely Rouzee , Hashim Nur Idzhainee 
Published: November 2018

Marine tourism is one of the main factors contributing to the growth of the tourism sector in Malaysia. Malaysia is among the countries that have assets of most beautiful islands with diverse marine life. It is attracting visitors to enjoy the beauty of the sea nature. The vibrant activity was an opportunity for local community to engage in the tourism sector. Thus, this study was conducted to determine the perceptions of local community towards the impact of tourism activities in Pulau Pangkor. The study involved 150 respondents among the local community that involved in the tourism sector.
Molecular identification of <i>Auxis</i> spp. larvae (Pisces: Scombridae) from the Gulf of California: Solving morphological identification limits
Authors: Ochoa-Muñoz María J. , Díaz-Viloria Noé , Sánchez-Velasco Laura , Jiménez-Rosenberg Sylvia P. A. , Pérez-Enríquez Ricardo 
Published: November 2018

The larvae of the Auxis genus are abundant in the Gulf of California during summer; however, their identification to the species level by morphological methods is a challenge. The goal of this study was to identify A. thazard and A. rochei larvae for first time, through molecular markers using COI sequences of mtDNA, and look for distinctive morphological characteristics between species, mainly in pigmentation patterns. Larvae were obtained by zooplankton tows in 3 oceanographic cruises in the southern Gulf of California and adjacent waters. The presence of A. thazard and A. rochei larvae was genetically confirmed. The sequences of 7 larvae showed genetic divergences lower than 1% when were compared to sequences of A. thazard adults, while 15 larvae showed genetic divergences lower than 2% when where compared to sequences of A. rochei adults. Genetic divergences between both Auxis species were higher than 2%. These results suggest the spawning of both species in the Gulf of California. On the other hand, pigmentation patterns and morphometric characteristics, in all larval stages, did not permit the secure differentiation between species. Thus, the use of molecular identification by COI is recommended to identify Auxis larvae to the species level, as well as in other marine fish larvae collected in other regions of the world, that have identification troubles.
Comunicação, sistemas complexos e transdisciplinaridade: um comunicar intercientífico
Authors: Regis Fátima 
Published: November 2018

A alta capacidade de processamento de dados viabilizada pelo advento do computador proporciona uma nova forma de empiricidade para testar teorias as simulações computacionais. Esta nova técnica produz duas novidades. Primeira: permite a investigação dos sistemas complexos, inalcançáveis pelos métodos científicos conhecidos até então. Segunda: por suas características intrínsecas, opera entre os terrenos do real e do ficcional. Esses dois aspectos produzem um abalo nas fronteiras epistemoilógicas modernas, colaborando para a inauguração de um novo paradigma científico - a complexidade. O objetivo do artigo é duplo. Primeiro: discutir como a complexidade abala as fronteiras epistemológicas modernas de duas maneiras, mostrando a inter-dependência entre diversas disciplinas e usando um método que agrega aspectos ficcionais à ciência. Segundo: mostrar que as trocas de informação e as interações entre os componentes constituem o cerne dos sistemas complexos. Assim, encaminhamos a hipótese de que o modelo do processo
de comunicação toma-se fundador da lógica de funcionamento deste novo paradigma, transdisciplinar por excelência.
Ligações perigosas: o diálogo ilusório entre enigma e erotismo na herança midiática das Lettres Portugaises
Authors: Silveira Ada Cristina Machado 
Published: November 2018

O artigo reflete a partir do caso paradigmático da herança midiatica
da obra literária Lettres Portugaises. Estudamos injunção entre uma
obra literária e a cadeia intermidiática que, a partir da primeira, é passível
de notório reconhecimento. Perguntamos qual seria a apropriação da obra
literária referida para a cultura midiática contemporánea, especialmente para
algumas produções cinematográficas originadas da literatura epistolar. Há
algumas respostas que envolvem o trajeto da obra referida como literatura
canônica na formação escolar e que envolvem especialmente as relações entre
um amor enigmático e o erotismo. As narrativas femininas fazem parte
da cultura da mídia e a elas se empresta um caráter especial. Reflexo disso
é a aparição de Novas cartas portuguesas, três séculos depois e ironicamente
causando também um grande impacto. Também referimos à estigmatização
das Mariana-Marias e sua condição de anti-sujeito, o ainda presente enigma
das identidades de autoria e das personagens e a cultura midiática em torno
ao tema cia literatura epistolar e do erotismo.
A ficção literária nesse novo tempo
Authors: Fontes Lilian 
Published: November 2018

Considerando que as narrativas ficcionais, sejam elas literárias ou
audiovisuais, vem sendo estudadas corno um vasto campo para se obter dados referentes às características do imaginário contemporâneo no campo da estética, sociedade, cultura e política, portanto, corno processo comunicacional,
o presente artigo pretende abordar a influência da velocidade acelerada das novas tecnologias, dos meios de comunicação e da mídia no pensamento estético atual e a sua relação com a produção ficcional literária.
MARCAS DE TRANSIÇÃO: Comunicação, cultura e novos significados do consumo no (pós)-socialismo
Authors: Martineli Fernanda 
Published: November 2018

Este trabalho discute a abertura econômica e as recentes
configurações do consumo em antigos países socialistas. Investiga como o consumo de objetos e valores tradicionais capitalistas se justifica, a partir de quais referenciais o discurso publicitário é construído e como se articulam significados implementados durante o regime socialista com novos referenciais de cultura e economia. Acredita-se que essa abertura acompanha uma euforia pelo consumo comparada àquela que o Brasil viveu nos anos 1990, quando o neoliberalismo se firmava endossando o mercado como modelo social de liberdade e progresso, e o universo do consumo como espaço privilegiado de exercício de liberdade. A análise dessas dinâmicas se apóia em Douglas e Isherwood (2004), entendendo os bens como sistema de comunicação, pois transmitem mensagens sobre gostos, estilos, identidades e hierarquias sociais nas práticas de consumo.