bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I
Authors: Xiao Jin , Xiang Wangzhen , Zhang Yongli , Peng Weiyu , Zhao Min , Niu Ling , Chai Yan , Qi Jianxun , Wang Fei , Qi Peng , Pan Chungang , Han Lingxia , Wang Ming , Kaufman Jim , Gao George F. , Liu William J. 
Published: October 2018

Abstract
MHC molecules are found in all jawed vertebrates and are known to present peptides to T lymphocytes. In mammals, peptides can hang out either end of the peptide-binding groove of classical class II molecules, whereas the N and C termini of peptides are typically tightly bound to specific pockets in classical class I molecules. The chicken MHC, like many nonmammalian vertebrates, has a single dominantly expressed classical class I molecule encoded by the BF2 locus. We determined the structures of BF2*1201 bound to two peptides and found that the C terminus of one peptide hangs outside of the groove with a conformation much like the peptides bound to class II molecules. We found that BF2*1201 binds many peptides that hang out of the groove at the C terminus, and the sequences and structures of this MHC class I allele were determined to investigate the basis for this phenomenon. The classical class I molecules of mammals have a nearly invariant Tyr (Tyr84 in humans) that coordinates the peptide C terminus, but all classical class I molecules outside of mammals have an Arg in that position in common with mammalian class II molecules. We find that this invariant Arg residue switches conformation to allow peptides to hang out of the groove of BF2*1201, suggesting that this phenomenon is common in chickens and other nonmammalian vertebrates, perhaps allowing the single dominantly expressed class I molecule to bind a larger repertoire of peptides.
Prevalence and outcomes of central venous catheter-related bacteraemia in HIV-infected versus non-HIV-infected patients undergoing haemodialysis treatment for end-stage kidney disease
Authors: Avila-Danguillecourt Nuria , Moodley Anand A. , Makinga Polycarpe 
Published: October 2018

Background: Central venous catheter (CVC) haemodialysis (HD) to implement renal replacement therapy is the preferred choice in the urgent setting. Unfortunately, CVC placement is associated with multiple complications including nosocomial bloodstream infections. There is a paucity of data on the prevalence and pattern of pathogenic organisms in haemodialysed HIV-infected versus non-HIV-infected patients with end-stage kidney disease.Method and results: We undertook a retrospective study of 228 patients who were dialysed using a CVC at a tertiary referral hospital in KwaZulu-Natal, South Africa. Seventy-eight patients (34.2%) complicated with bacteraemia and sepsis requiring antibiotics. Removal of the catheter was necessary in 58 patients (74.0%). The most common organisms isolated were Staphylococcus aureus (30.8%), Staphylococcus epidermidis (24.4%) and Klebsiella pneumoniae (15.4%). There was no statistically significant difference between HIV-infected and non-infected patients with regards to infection rate, time interval from insertion of CVC to infection and final outcome. However, HIV-infected patients took longer to recover; 54.3% of non-infected patients versus 10.3% HIV-infected patients had their sepsis controlled within one week. Acidosis, hypotension, line malfunction and line discharge were infrequent signs of sepsis. Fever, rigors and raised white cell count occurred in over 80.0% of patients.Conclusion: The infection rate in CVC HD is not more frequent in HIV-infected patients, provided that CD4+ count is ≥ 200 cells/µL and the patient is virologically suppressed. Outcomes following intravenous antibiotic and removal of the CVC are similar in HIV-infected and non-infected patients but response to treatment is slower in HIV-infected patients. A high index of suspicion is needed in detecting CVC-related bacteraemia.
Revisiting substorm events with preonset aurora
Authors: Miyashita Yukinaga , Ieda Akimasa 
Published: October 2018

Abstract. Nishimura et al. (2010) proposed a new plasma intrusion or preonset aurora
scenario of substorm triggering. In this scenario, a substorm is triggered by
a fast earthward flow generated at the distant neutral line which corresponds
to a preonset auroral streamer or arc in the ionosphere propagating from the
auroral poleward boundary to the initial auroral brightening site, i.e.,
“preonset aurora”. In the present paper, we revisited three substorm events
reported as being triggered by such a mechanism related to preonset auroras,
based on THEMIS ground-based all-sky imager data. Unlike previous studies, we
examined the arrival timing of the preonset aurora relative to the three
steps of auroral onset arc development (initial brightening, enhancement of
the wave-like structure, and poleward expansion) to make the role of the
preonset aurora in the auroral steps clearer. Our detailed timing analysis
found that preonset auroral streamers reached the auroral onset arc but away
from the initial brightening site after initial brightening for two events,
while no preonset aurora reaching the initial brightening site could be
identified for the other event. This result suggests that the processes
associated with auroral streamers are unlikely to affect at least initial
brightening, even if we consider not only the presence and arrival timing and
location of the auroral streamers but also the scale of the corresponding
flow and flow vortices. We list a series of open questions for testing the
preonset aurora scenario further in future studies. Keywords. Magnetospheric physics (storms and substorms; auroral phenomena; magnetotail)
Analysis of the streamflow extremes and long-term water balance in the Liguria region of Italy using a cloud-permitting grid spacing reanalysis dataset
Authors: Silvestro Francesco , Parodi Antonio , Campo Lorenzo , Ferraris Luca 
Published: October 2018

Abstract. The characterization of the hydro-meteorological extremes, in terms of both
rainfall and streamflow, and the estimation of long-term water balance
indicators are essential issues for flood alert and water management
services. In recent years, simulations carried out with meteorological models
are becoming available at increasing spatial and temporal resolutions (both
historical reanalysis and near-real-time hindcast studies); thus, these
meteorological datasets can be used as input for distributed hydrological
models to drive a long-period hydrological reanalysis. In this work we adopted
a high-resolution (4 km spaced grid, 3-hourly) meteorological reanalysis
dataset that covers Europe as a whole for the period between 1979 and 2008.
This reanalysis dataset was used together with a rainfall downscaling
algorithm and a rainfall bias correction (BC) technique in order to feed a
continuous and distributed hydrological model. The resulting modeling chain
allowed us to produce long time series of distributed hydrological variables for
the Liguria region (northwestern Italy), which has been impacted by severe
hydro-meteorological events. The available rain gauges were compared with the rainfall estimated by the
dataset and then used to perform a bias correction in order to match the
observed climatology. An analysis of the annual maxima discharges derived by
simulated streamflow time series was carried out by comparing the latter
with the observations (where available) or a regional statistical analysis
(elsewhere). Eventually, an investigation of the long-term water balance was
performed by comparing simulated runoff ratios (RRs) with the available
observations. The study highlights the limits and the potential of the considered
methodological approach in order to undertake a hydrological analysis in
study areas mainly featured by small basins, thus allowing us to overcome the
limits of observations which refer to specific locations and in some cases are not fully reliable.
Enhancing Rural Population Health Care Access and Outcomes Through the Telehealth EcoSystem™ Model
Authors: Leath Brenda , Dunn Lucenia W. , Alsobrook Antwon , Darden Madeline L 
Published: October 2018

Abstract The article highlights the Telehealth Ecosystem™ model, a holistic cross sector approach for socioeconomic revitalization, connectivity, interoperability and technology infrastructure development to address health equity for rural underserved communities. Two guiding frameworks, Community & Economic Development (CED) and Collective Impact, provided the foundation for the Telehealth Ecosystem™ model. Public and private organizational capacities are addressed by comprehensive healthcare and social service delivery through stakeholder engagement and collaborative decision-making processes. A focus is maintained on economic recovery and policy reforms that enhance population health outcomes for individuals and families who have economic challenges. The Telehealth EcoSystem™ utilizes an Intranet mechanism that enables a range of technologies and electronic devices for health informatics and telemedicine initiatives. The relevance of the Intranet to the advancement of health informatics is highlighted. Best practices in digital connectivity, HIPPA requirements, EHRs, and eHealth applications, such as patient portals and mobile devices are emphasized. Collateral considerations include technology applications that expand public health services. The ongoing collaboration between a social science research corporation, a regional community foundation and an open access telecommunications carrier is a pivotal element in the sequential development and implementation of the Telehealth EcoSystem™ model in the rural southeastern region community.
Karp, M. (2016). This Vast Southern Empire: Slaveholders at the Helm of American Foreign Policy. Cambridge: Harvard University Press. 360 pages.
Authors: Caprice Kevin 
Published: October 2018

En This Vast Southern Empire, Matthew Karp se aleja de la historiografía anterior de la esclavitud del Sur antes de la guerra, una historiografía que sitúa a los esclavistas como anticuados y mirando hacia adentro, y, en cambio, Karp ve una élite esclavista del sur mirando hacia afuera en un intento de consagrar su visión. de la modernidad: una economía mundial basada en el trabajo esclavo. Karp remata su estudio con la emancipación británica de las Indias Occidentales en 1833, vista por los sureños como una amenaza global a la proliferación de la esclavitud, y la creación y el fracaso final de los Estados Confederados de América, que Karp considera el “proyecto de política exterior más audaz todos ”(pág. 2). En esta nueva versión, Karp sostiene que, desde 1833 hasta 1861, las élites del sur utilizaron con entusiasmo el poder federal para garantizar la seguridad de la esclavitud, no solo en los Estados Unidos, sino en todo el hemisferio occidental.
In This Vast Southern Empire, Matthew Karp steps back from the previous historiography of the slaveholding antebellum South, a historiography that situates slaveholders as antiquated and inward looking, and, instead, Karp sees a slaveholding Southern elite looking outward in an attempt to enshrine their vision of modernity: a world economy run on slave labor. Karp bookends his study with the 1833 British emancipation of the West Indies, seen by Southerners as a global threat to the proliferation of slavery, and the creation and ultimate failure of the Confederate States of America, which Karp deems the “boldest foreign policy project of all” (p. 2). In this fresh take, Karp argues that, from 1833 to 1861, Southern elites eagerly utilized Federal power to secure the safety of slavery, not just in the United States, but throughout the Western Hemisphere.
La mujer como exemplum. Subversión, desafío y resistencia en Valerio Máximo.
Authors: González Estrada Lidia 
Published: October 2018

En el presente texto tratamos de adentrarnos en la complejidad de la acción femenina que, representadas en obras como la de Valerio Máximo, basadas en la ejemplaridad, permite vislumbrar las distintas formas de proceder de las mujeres en la sociedad romana. En los casos que presentamos, no solo podemos ver más allá de los estereotipos, sino que también apreciamos a las mujeres rebelándose contra los roles de género y la moralidad que la sociedad les impone, ya sea como madres, esposas o ciudadanas.
The following article dives into the complexity of women’s actions represented in ancient accounts such as Valerius Maximus’. Through the inquiry of these works based on the Roman idea of exempla, it is intended to draw an extensive analysis of women’s role in the Roman society. In the studied cases, it is not only possible to see beyond the stereotypes but can also be noted the women’s rebellion against gender roles and the morality imposed by the society, either as mothers, wives or citizens.
Modelos de conciencia histórica en el alumnado de Educación Secundaria: tradición, simbología y contextualización en torno a los restos del franquismo.
Authors: Miguel-Revilla Diego , Sánchez Agustí María 
Published: October 2018

El concepto de conciencia histórica, ligado con las concepciones del pasado y futuro en relación al presente, sirve como marco de análisis sobre las ideas del alumnado de Historia. La presente investigación ha contado con 132 estudiantes de cuarto curso de la ESO de cuatro ciudades españolas, con los que se ha trabajado en torno a la Transición española a través de un entorno digital de aprendizaje. Ante una problemática relacionada con la pervivencia de restos patrimoniales de la etapa franquista, y mediante un análisis cualitativo, el estudio centra su atención en caracterizar los modelos de conciencia histórica del alumnado. Los resultados identifican rasgos clave en sus concepciones, incluyendo la influencia de la tradición y una preocupación por la simbolización, corroborando además que la visión genealógica, ligada a la contextualización, es menos frecuente que las visiones tradicional, ejemplar y crítica.
The concept of historical consciousness, associated to past and future conceptions in relation to the present, is useful as an analytical framework focusing on history students’ ideas. This paper has counted on the participating of 132 fourth-year compulsory secondary education students from four different cities in Spain, who have worked about the Spanish transition to democracy with a digital learning environment. Using a controversial issue linked with the continuity of patrimonial remains of the Francoist era, and by means of a qualitative analysis, this study centers its attention in characterizing students’ historical consciousness models. The results help identify key characteristics in their conceptions, including the influence of tradition and a concern for symbolization, corroborating that the genetic vision, related to contextualization, is less common than the traditional, exemplary and critical ones.
La importancia de la contextualización curricular en la enseñanza de la Historia en México.
Authors: Bautista Rojas Enrique 
Published: October 2018

El propósito de este trabajo es analizar la importancia de la contextualización curricular en la enseñanza de la historia en la escuela secundaria en México. Esto implica la generación de experiencias educativas que favorezcan el desarrollo del pensamiento histórico a partir de la construcción de aprendizajes significativos y situados que consideren las características de los estudiantes y su entorno. Se discute tomando referentes teóricos derivados del socioconstructivismo para criticar la forma en que tradicionalmente se ha enseñado la historia en este nivel educativo, lo que ha dado por resultado procesos poco relevantes en la vida escolar y cotidiana de las y los jóvenes. Al abordar este tema, se busca brindar pautas de reflexión y puntos para guiar el trabajo de los docentes y favorecer su compromiso hacia la formación de futuros ciudadanos críticos, informados y comprometidos con su sociedad
The intention of this paper is to analyze the importance of curricular contextualization in the history teaching in Mexican junior high school. This implies the generation of educational experiences that support the development of historical thinking through the construction of significant and situated learnings that consider the characteristics of students and their environment. The discussion takes references derived from the social constructivist theory and criticizes the traditional teaching of history in this educational level. This teaching method has resulted in unimportant processes in the school and daily life of young people. The work seeks to provide reflection guidelines and points to guide the teaching practice and promote its commitment to the formation of future critical, informed and committed citizens to their society
Experiencia didáctica para la enseñanza de la historia contemporánea a través de las fuentes en Educación Superior.
Authors: Llonch-Molina Nayra , Parisi-Moreno Verónica 
Published: October 2018

El presente trabajo muestra una experiencia de innovación docente en didáctica de la historia. La experiencia se llevó a cabo en el Grado de Educación Primaria y se basó en el uso combinado de fuentes primarias y recursos digitales, con el objetivo de desarrollar un modelo alternativo de enseñanza-aprendizaje de la historia que fomentara competencias de pensamiento histórico. El estudio de caso realizado desvela que dicha experiencia de innovación docente permite que los maestros en formación inicial pongan en práctica contenidos conceptuales y procedimentales determinantes para la adquisición de contenidos y de metodologías de enseñanza-aprendizaje de las Ciencias Sociales y la Historia
This paper presents an experience of teaching innovation in didactics of history. The experience was carried out in initial teacher training and was based on the combined use of primary sources and digital resources, with the aim of developing an alternative teaching-learning model of history that fosters historical thinking competences. The work done by the participants evidences that the experience allows teachers in initial training to put into practice conceptual and procedural contents that are decisive for the acquisition of both contents and teaching-learning methodologies of the Social Sciences and History
Talking to James Baldwin: Alain Mabanckou’s Jimmy
Authors: Schwarz Bill 
Published: October 2018

«
Talking to James Baldwin
»
explores the consequences of the intimacy which many readers experience when they read Baldwin’s prose. What are we to do when we confront this intimacy ? What ethical questions does this raise ? What is there in Baldwin’s writings which enables us to imagine productively the relations between the dead and the living ?
L’évaluation stratégique : une démarche qui favorise la gestion démocratique des projets de territoire
Authors: Soldo Edina , Arnaud Charlène 
Published: October 2018

Cette recherche vise à questionner les démarches évaluatives dans leur capacité à favoriser la gestion démocratique de projets de territoire. Deux conditions principales d’une telle gestion peuvent être identifiées. Elle poursuit des finalités démocratisantes et garantit dans le même temps, des processus décisionnels et modalités de gouvernance démocratisés (1). Face à la nécessité de développer des méthodes d’accompagnement à la mise en oeuvre de projets de territoire, l’évaluation stratégique apparaît comme une démarche opportune. Ses quatre caractéristiques essentielles : une temporalité « chemin faisant », des modalités de gouvernance pluralistes et participatives, une posture de recherche-action ainsi qu’un protocole méthodologique mixte original, favorisent en effet, l’enracinement démocratique de tels projets (2).
Émergence de nouvelles pratiques managériales et vulnérabilité
Authors: Delassus Éric , Silva François 
Published: October 2018

La notion de vulnérabilité issue des éthiques ducare, pourrait-elle trouver sa place dans une refondation de la pensée managériale ? Les nouvelles formes d’organisation du travail, qui valorisent plus les relations entre les personnes que les performances individuelles, pourraient intégrer cette notion pour faire émerger un management humaniste favorisant la confiance et la sollicitude. Une culture de la responsabilité remettant en cause une vision gestionnaire des relations humaines et prenant en compte de la singularité de chacun verrait alors le jour. L’autorité du manager, plus compréhensive envers autrui et soucieuse de le faire progresser, y trouverait une nouvelle légitimité.
Effects of graded concentrations of supplemental selenium on selenium concentrations in tissues and prediction equations for estimating dietary selenium intake in pigs
Authors: Son Ah Reum , Jeong Jin-young , Park Kyu Ree , Kim Minseok , Lee Sung Dae , Yoo Ji-Hyock , Do Yoon-Jung , Reddy Kondreddy Eswar , Lee Hyun-Jeong 
Published: October 2018

The experiment was conducted to determine the effects of graded dietary selenium (Se) on organ weight and Se concentrations in tissues and to develop equations for estimating dietary Se intake in pigs. Sixteen barrows (initial body weight = 30.0 ± 2.6) were allotted to four dietary treatments including graded Se supplementations with 0, 1, 5, and 50 mg/kg of diet. The experimental diets fed to the pigs for 30 d, and then the pigs were euthanized, and the organs, muscle, and urine samples were collected. The hair and blood samples of pigs were collected on d 15 and 30. Equations were developed for predicting daily Se intake using the Se concentration in plasma, hair, liver, kidneys, muscle, or urine. For graded dietary Se concentrations, linear and quadratic effects on the final body weight, weight and relative weight of liver and kidneys were not observed. The Se concentration in plasma, hair, liver, kidneys, muscle, and urine were linearly and quadratically increased as dietary Se concentration increased (P < 0.001). The dietary Se concentration was positively correlated with the Se concentrations in the plasma, organs, muscle, and urine (r > 0.81,P < 0.001). The equations for estimating dietary Se intake using the Se concentration in the plasma, hair, or organ as an independent variable were significant (P < 0.05). In conclusion, the dietary Se concentration was well reflected in the Se concentration in the plasma, hair, liver, kidneys, and urine. The Se concentration in the plasma, hair, liver, and kidneys can be used as an independent variable for estimating the Se intake.