bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cannabis Vaping Among US Adults With Disabilities: Findings From the 2022 Behavioral Risk Factor Surveillance System
Authors: Olufemi Erinoso , Olatokunbo Osibogun , Wei Li , Ben Taleb Ziyad , Kalan Mohammad Ebrahimi 
Published: November 2024

Objectives: Studies have demonstrated that people with disabilities are more likely to use cannabis than people without disabilities. However, less is known about novel forms of use, such as cannabis vaping, in this population. We examined the correlates of cannabis vaping among people with disabilities and the association between cannabis vaping and the frequency of cannabis use in any form. Methods: We used data from the 2022 Behavioral Risk Factor Surveillance System to examine the association between disabilities and past-month cannabis vaping, as well as the number of days that cannabis was used in the past month, among US adults. We used weighted multivariable logistic and modified Poisson regression models with incidence rate ratios to examine the associations. Results: The prevalence of cannabis vaping was higher among adults with any disability (4.6%) than among adults without disabilities (2.8%); adults with only cognitive disabilities had the highest prevalence (8.2%). Daily nicotine vaping (adjusted odds ratio [AOR] = 6.04; 95% CI, 4.14-8.80), former cigarette smoking status (AOR = 1.67; 95% CI, 1.25-2.25), and being aged 18-24 years (vs ≥65 y) (AOR = 11.07; 95% CI, 7.05-17.38) were associated with higher odds of cannabis vaping among adults with any disability. Disability status modified the relationship between cigarette smoking and cannabis vaping ( P < .001). Additionally, among adults with disabilities, the rate of cannabis-use days was higher among adults who vaped cannabis (adjusted incidence rate ratio = 1.28; 95% CI, 1.19-1.36) than among adults who did not vape cannabis. Conclusions: Among adults with disabilities, nicotine consumption by vaping was associated with cannabis vaping. Our findings highlight the need for interventions that reduce the risk of polysubstance use (ie, nicotine and cannabis) in this population.
The Foundation of Pi-Ramesse: Strengthening the Rule of the 19th Dynasty and Displaying Egypt to the Outside World
Authors: Franzmeier Henning 
Published: November 2024

In the past, the statement from P. Anastasi II, that everybody left his city to settle in Pi-Ramesse, has mainly been interpreted in a somewhat propagandistic sense – everybody wanted to leave their old city to come to the marvellous new capital with all its wonders. While this interpretation might have been the author’s intention, based on the reality of a new capital, it can be interpreted in different ways: a new place needs people to function. This gave the founder of the new city the opportunity to carefully choose these people to enhance and stabilize his power. Moreover, the city, with its particular location, served as a gateway into Egypt and thus also as a showcase to foreigners. The Egyptian sovereigns could demonstrate their power and access to resources by monumental building. This contribution aims to highlight some rarely discussed motivations for the foundation of Pi-Ramesse. [Formula: see text]
An Assemblage of Ceramic Figurines from the Site of Tell Nabasha
Authors: Nielsen Nicky , Bebbington Christopher 
Published: November 2024

Sixteen ceramic figurines were discovered during excavations in 2015 at the site of Tell Nabasha by a team from the University of Liverpool. The figurines were found in several contexts dating from the Late to the early Ptolemaic Period. This article presents the assemblage and discusses the function of these figurines within the sacred landscape of Tell Nabasha linking them to the worship of primarily two local deities: Wadjet, Mistress of Imet, and Harpocrates. The figurines were most likely produced on the site and donated as votive offerings to the local temple, particularly during festivals conducted at the site. [Formula: see text]
Diagnostic Accuracy of Magnetic Resonance Imaging in the 120° Flexed-Knee Position for Detecting and Classifying Meniscal Ramp Lesion
Authors: Nonaka Satoshi , Hatayama Kazuhisa , Tokunaga Shintarou , Kakiage Hibiki , Hirasawa Satoshi , Terauchi Masanori , Chikuda Hirotaka 
Published: November 2024

Background: Detection of meniscal ramp lesions concomitant with anterior cruciate ligament (ACL) injury using conventional magnetic resonance imaging (MRI) has low sensitivity, and these lesions are currently difficult to diagnose preoperatively. Purpose/Hypothesis: The purpose of this study was to assess the accuracy of MRI in detecting the presence of meniscal ramp lesions in the 120° flexed-knee position compared with that in the near–extended-knee position. It was hypothesized that the diagnostic performance of MRI in the 120° flexed-knee position would be better than that in the extended-knee position. Study Design: Cohort study (Diagnosis); Level of evidence, 2. Methods: This retrospective study of prospectively collected data between February 2019 and January 2024 included 154 consecutive patients undergoing ACL reconstruction. All patients underwent 3-T MRI examination in the near extended- and 120° flexed-knee positions preoperatively. The presence and Thaunat classification of ramp lesions were separately detected on each MRI scan and confirmed via arthroscopy during ACL reconstruction. Diagnostic sensitivity, specificity, and conditional relative odds ratios for detecting ramp lesions and the classification accuracy were compared between 2 MRI modalities. The accuracies of these MRI scans in acute and chronic cases were also evaluated. Results: This study included 154 patients (79 male and 75 female; mean age, 29.0 ± 14.2 years). A total of 62 ramp lesions (40.3%) were observed on arthroscopy. The sensitivity and specificity of MRI in near extension were 69.4% and 77.2%, respectively, and those in flexion were 91.9% and 94.6%, respectively, with significant superiority in MRI at knee flexion ( P = .003 and P < .001, respectively). The conditional relative odds ratio between the MRI examinations at these 2 positions was 10.3 (95% CI, 4.82-21.8). The classification accuracy of MRI in flexion was significantly higher than that of MRI in near extension (accuracy, 49 vs 11; P < .001). The diagnostic accuracy of MRI in the 120° flexed-knee position was significantly higher than that in the near–extended-knee position in the acute cases ( P < .05); however, no significant differences were observed in the chronic cases. Conclusion: The diagnostic accuracy of MRI in the 120° flexed-knee position for detecting and classifying meniscal ramp lesions was superior to that of MRI in the near–extended-knee position.
Physical Activity as a Predictor of Internet Gaming Disorder in a Swiss Male Cohort (C-SURF): L’activité physique comme prédicteur des troubles liés aux jeux vidéo en ligne dans une cohorte de jeunes hommes suisses (C-SURF)
Authors: Nowotarski Adam , Rothen Stephane , Kasina Filip , Zullino Daniele , Thorens Gabriel 
Published: November 2024

History and Objectives This study addresses the increasing global concerns surrounding Internet gaming disorder (IGD) by exploring their connection to physical activity (PA) as a potential preventive and early intervention measure. The research aims to examine the relationship between PA and the progression of IGD. Methods Longitudinal data from the Cohort research on Substance Use Risk Factors involving young Swiss men undergoing army conscription was employed. PA levels were assessed using the International PA Questionnaire (IPAQ), while the Game Addiction Scale (GAS) and Compulsive Internet Use Scale determined IGD presence. Analysis involved zero-inflated negative binomial regression models. Results Higher PA levels were associated with lower IGD risk. Notably, individuals engaging in high physical exercise exhibited a lower IGD prevalence compared to those with moderate or low activity levels. Discussion The study suggests that intensive physical exercise might serve as a preventive strategy against developing IGD. This protective effect could stem from various mechanisms. However, the study's limitations, such as a male-only sample and a small low-activity group, should be considered when interpreting results. Conclusion The longitudinal study demonstrates the positive influence of intense physical exercise on mitigating gaming-related issues. These findings underscore the potential of PA interventions in addressing the growing problem of IGDs and their impact on health. Further research is necessary to uncover underlying mechanisms behind the PA–IGD relationship and validate these findings across diverse demographics.
Patients with multiple sclerosis have higher rates of worsening following total hip arthroplasty: a propensity-matched analysis
Authors: Lim Perry L , Sauder Nicholas , Sayeed Zain , Esantsi Michael , Bedair Hany S , Melnic Christopher M 
Published: November 2024

Introduction: The progressive nature of multiple sclerosis (MS) may adversely affect outcomes following total hip arthroplasty (THA). As patient-reported outcome measures (PROMs) in this specific group are not well defined, this study aimed to compare the clinical outcomes and the rates of achieving the minimal clinically important difference for improvement (MCID-I) and worsening (MCID-W) between patients with MS and those without MS undergoing THA. Methods: We conducted a retrospective analysis of 375 THAs, including 75 MS patients and 300 propensity-matched non-MS patients (4:1), performed between 2016 and 2022. Collected PROMs included Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health Mental and Physical, PROMIS Physical Function short form 10-a (PF-10a), and Hip disability and Osteoarthritis Outcome Score-Physical Function Short-form (HOOS-PS). Preoperative and postoperative PROMs and MCID-I/MCID-W rates were compared. Results: A total of 375 THAs, including 75 MS and 300 matched non-MS patients, were analysed. MS patients had higher 90-day postoperative complication rates (9.3% vs. 2.3%, p = 0.012) and infection rates (4.0% vs. 0.3%, p = 0.006). The rates of achieving MCID-I and MCID-W were similar for PROMIS Global Mental, PROMIS Global Physical, and HOOS-PS, but MS patients had a higher rate of experiencing MCID-W for PROMIS PF-10a compared to non-MS patients (16.7% vs. 6.5%, p = 0.022). Additionally, MS patients had a longer mean hospital stay (2.4 vs. 1.9 days, p = 0.005) and lower rates of being discharged home (82.7% vs. 94.3%, p < 0.001). Conclusions: The present study found that MS patients experience similar rates of MCID-I and MCID-W in most PROMs but have a higher rate of MCID-W for PROMIS PF-10a and increased postoperative complications. These findings highlight the need for careful consideration of postoperative risks despite potential improvements. Further research is needed to explore the impact of MS progression on PROMs and perioperative outcomes.
Improving Enhanced Recovery after Surgery (ERAS): The Effect of a Patient-Centred Mobile Application and an Activity Tracker on Patient Engagement in Colorectal Surgery
Authors: van der Storm Sebastiaan L. , Jansen Marilou , Mulder Malou D. , Marsman Hendrik A. , Consten Esther C.J. , den Boer Frank C. , de Boer Hans D. , Bemelman Willem A. , Buskens Christianne J. , Schijven Marlies P. ,   on behalf of the ERAS APPtimize collaborative study group
Published: November 2024

Background The Enhanced Recovery After Surgery (ERAS) protocol improved perioperative colorectal care. Although the protocol is firmly implemented across hospital settings, there are benefits to gain by actively involving patients in their recovery. The main objective of this study was to investigate whether compliance with selected items in the ERAS protocol could further improve by using a patient-centred mobile application. Method This multicentre, randomised controlled trial was conducted between October 2019 and September 2022. Patients aged 18 years or older who underwent elective colorectal surgery, and in possession of a smartphone were included. The intervention group used a mobile application combined with an activity tracker to be guided and supported through the ERAS pathway. The control group received standard care and wore an activity tracker to monitor their daily activities. The primary outcome was overall compliance with selected active elements of the ERAS protocol. Results In total, 140 participants were randomised to either the intervention (n = 72) or control group (n = 68). The use of the ERAS App demonstrated a significant improvement in overall compliance by 10%, particularly in early solid food intake by 42% and early mobilization by 27%. Postoperative or patient reported outcomes did not differ between groups. Conclusion The smartphone application ‘ERAS App’ is able to improve adherence to the active elements of the ERAS protocol for colorectal surgery. This is an important step towards optimizing perioperative care for colorectal surgery patients and enabling patients to optimize being in control of their own recovery. Trial registration: ERAS APPtimize, NTR7314 ( https://trialsearch.who.int/Trial2.aspx?TrialID=NL-OMON29410 ).
Real-world therapeutic performance of pirfenidone for connective tissue disease-associated interstitial lung diseases
Authors: Yuan Xueting , Yu Chen , Liu Shengyun , Shu Qiang , Duan Xinwang , Tang Lin , Peng Liying , Zhou Shuang , Wu Chanyuan , Zhao Jiuliang , Xu Dong , Song Lan , Huang Hui , Li Mengtao , Wang Yanhong , Wang Qian , Zeng Xiaofeng 
Published: November 2024

Background: Pirfenidone (PFD) is commonly applied for antifibrotic treatment in patients with idiopathic pulmonary fibrosis but has rarely been studied in cases with connective tissue disease-associated interstitial lung diseases (CTD-ILDs). Objectives: We aimed to examine the efficacy of PFD in patients with CTD-ILD based on real-world data. Design: A retrospective cohort study. Methods: This study assessed the clinical features of CTD-ILD patients with or without a 6-month PFD treatment. A linear mixed effects model was employed to evaluate the effectiveness of PFD in alleviating lung function changes. Differences in response to PFD were analyzed based on CTD subtype, imaging classification, and pattern of pulmonary function at baseline. Results: A total of 289 patients with CTD-ILD were included, with 155 (53.6%) receiving PFD treatment and the remaining constituting the control group. Patients with the usual interstitial pneumonia (UIP) pattern were more likely to receive PFD treatment, and a relatively lower proportion of cases in the PFD group received immunosuppressive therapies compared to the control group ( p < 0.05). At the 6-month follow-up, patients in the PFD group demonstrated a more significant improvement in forced vital capacity (FVC) and diffusion capacity for carbon monoxide (DLCO) (ΔFVC%: 2.9% vs 0.45%, p = 0.009; ΔDLCO%: 1.9% vs −1.1%, p = 0.004). In the linear mixed model analysis, there was a statistically significant group-time interaction between FVC% and DLCO% changes over time (FVC%: β = 4.52, p < 0.001; DLCO%: β = 4.13, p = 0.003). Furthermore, subgroup analysis indicated that pirfenidone may have superior therapeutic effects in patients with systemic sclerosis (SSc)-associated ILD, non-UIP pattern, and restrictive pattern of lung function at baseline. Conclusion: This study provided real-world data demonstrating the effectiveness of PFD in terms of lung function improvement in patients with CTD-ILD.
Non-serious adverse events in patients with ulcerative colitis receiving etrasimod: an analysis of the phase II OASIS and phase III ELEVATE UC 52 and ELEVATE UC 12 clinical trials
Authors: Lees Charlie W. , Torres Joana , Leung Yvette , Vermeire Séverine , Fellmann Marc , Modesto Irene , McDonnell Aoibhinn , Lazin Krisztina , Keating Michael , Goetsch Martina , Wu Joseph , Loftus Edward V. 
Published: November 2024

Background: Etrasimod is an oral, once-daily (QD), selective sphingosine 1-phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). It is known that non-serious treatment-emergent adverse events (TEAEs) may not lead to UC drug discontinuation but can affect treatment tolerability. Objectives: This post hoc analysis evaluated the incidence of specific, common, non-serious TEAEs reported in the etrasimod UC clinical programme and the characteristics of affected patients. Design: Data included patients from the Placebo-controlled UC cohort (phase II OASIS, and phase III ELEVATE UC 52 and ELEVATE UC 12 trials) receiving QD etrasimod (2 or 1 mg) or placebo. Methods: Proportions and incidence rates (IRs; the number of patients with a TEAE divided by the total exposure in patient-years (PYs), per 100 PY) of Headache, Pyrexia, Nausea and Dizziness TEAEs were reported. Changes in heart rate among patients with Dizziness TEAEs were also evaluated. Results: Among 943 patients (etrasimod 2 mg, N = 577 (276.7 PY); etrasimod 1 mg, N = 52 (11.4 PY); placebo, N = 314 (115.1 PY)), 48, 34, 27 and 21 patients experienced events of Headache, Pyrexia, Nausea and Dizziness, respectively. All events were non-serious; one patient treated with etrasimod was discontinued due to a Pyrexia TEAE. Numerically, IRs of Headache and Dizziness TEAEs were higher, and Nausea slightly higher, with etrasimod versus placebo (13.45 vs 8.63 per 100 PY, 6.52 vs 1.69 and 7.18 vs 5.13 per 100 PY, respectively); IRs were similar for Pyrexia. The duration of most TEAEs was 1–10 days. Conclusion: In the etrasimod UC clinical programme, all Headache, Pyrexia, Nausea and Dizziness events were non-serious. Headache and Dizziness were more frequent, and Nausea slightly more frequent, among patients receiving etrasimod versus placebo. The post hoc nature of this analysis is a limitation. These results reiterate the favourable safety profile and tolerability of etrasimod. Trial registration: ClinicalTrials.gov: NCT02447302; NCT03945188; NCT03996369.
Hypothyroidism Predicts Fistula Development Following Salvage Oropharyngectomy
Authors: Prince Andrew D.P. , Huttinger Zachary M. , Heft-Neal Molly E. , Chinn Steven B. , Malloy Kelly M. , Stucken Chaz L. , Casper Keith A. , Prince Mark E.P. , Spector Matthew E. , Rosko Andrew J. 
Published: November 2024

Importance Previous work demonstrated postoperative hypothyroidism adversely affects wound healing in salvage laryngectomy. Currently, no studies have evaluated the association between wound healing and hypothyroidism in patients undergoing salvage oropharyngectomy. Objective The primary objective was studying hypothyroidism and other factors associated with oropharyngocutaneous fistula development and fistula requiring reoperation within 30 days after salvage oropharyngectomy. Design Retrospective cohort study. Setting Tertiary academic center. Participants All patients who underwent salvage oropharyngectomy for recurrent or second primary oropharyngeal squamous cell carcinoma between 2001 and 2017 after radiation or chemoradiation. Patients with no preoperative thyroid-stimulating hormone (TSH) values were excluded. Exposures Salvage oropharyngectomy for recurrent or second primary oropharyngeal squamous cell carcinoma. Main Outcomes Measures The principle explanatory variable was postoperative hypothyroidism, defined as TSH greater than 5.5 mIU/L. Univariate, bivariate, and binary logistical regression multivariate analysis was performed. Results Fifty-three patients met inclusion criteria, 37.7% of patients developed hypothyroidism, 18.9% developed a fistula, and 9.4% required an operation to manage the fistula. Postoperative fistula rate was 35% among hypothyroid patients, which was significantly greater than among euthyroid patients (9.1%; P = .03). A fistula requiring reoperation occurred in 20% of hypothyroid patients compared with that of euthyroid patients (3%; P = .061). In a multivariate analysis, postoperative hypothyroid patients were at a 9.5-fold increased risk of developing a fistula [95% confidence interval (CI) 1.6-57.0, P = .013]. Additionally, postoperative hypothyroid patients were at 13.6-fold increased risk for development of a fistula requiring reoperation (95% CI 1.2-160.5, P = .038). Conclusions and Relevance Postoperative hypothyroidism in patients who underwent salvage oropharyngectomy can predict fistula development and fistula requiring operative management. This study supports the treatment of hypothyroidism after surgery to reduce wound complications.
‘Assessing patients’ perception of the potential utility of visual function home monitoring app among patients with diabetes in Saudi Arabia’
Authors: Mofty Hanan Khalid , Abouammoh Marwan A , Al-Muqbil Hala A , AL-Zahrani Khaled S , AL-Ghasham Talhah M , Assiri Abdullah A , AL-Mnaizel Ahmad T , Mushcab Hayat S , Bokhary Kholoud A , Hogg Ruth E 
Published: November 2024

Aims To determine the acceptability and identify potential concerns and barriers of using a hypothetical smartphone application (app) for home monitoring (HM) of visual function among patients with diabetes. Methods Quantitative, cross-sectional study using a self-administered questionnaire. Patients diagnosed with diabetes aged between 20 and 70 years were included. The research was conducted across five regions in Saudi Arabia. The questions were adapted from a validated, published questionnaire and translated into Arabic. It focused on socio-demographic factors and barriers which associated with the acceptance of the hypothetical visual function HM app, using descriptive statistics. Results A total of 240 patients with diabetes participated in this study. About half of the participants (40.4%) ranged between 40 and 59 years; 42.5% were male, and most of the participants (93.8%) lived within 2 h of their healthcare facility. The rejection to the use of a hypothetical HM app was associated with increased age ( p = 0.025), lower education level ( p = 0.023), urbanicity ( p = 0.011), residing closer to health centres ( p = 0.021), and never experiencing telehealth services previously ( p = 0.025). Logistic regression revealed that accepting a hybrid clinic approach was more likely to be acceptable by younger patients (20–39 years: OR, 5.01; 95% CI, 1.82–13.82; p < 0.001; and 40–59 years: OR, 2.28; 95% CI, 0.084–5.00; p = 0.48), as well as patients who attended primary healthcare or specialised governmental clinics ( p = 0.038 and p = 0.019, respectively). Conclusion Factors that altered patients’ acceptance of the hypothetical app included their age, educational level, urbanicity, traveling distance, and telehealth experience. Therefore, careful consideration of acceptability and barriers is essential before implementing such an intervention.