bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of lateral heterogeneity on time-domain processing parameters
Authors: Sripanich Yanadet , Fomel Sergey , Stovas Alexey 
Published: August 2019

SUMMARY
Time-domain processing of seismic reflection data has always been an important engine that is routinely utilized to produce seismic images and to expeditiously construct subsurface models. The conventional procedure involves analysing parameters related to the derivatives of reflection traveltime with respect to offset including normal moveout (NMO) velocities (second-order derivatives) and quartic coefficients (fourth-order derivatives). In this study, we propose to go beyond the typical assumption of 1-D laterally homogeneous medium when relating those ‘processing’ parameters to the subsurface medium parameters and take into account the additional influences from lateral heterogeneity including curved interfaces and smoothly variable velocities. We fill in the theoretical gap from previous studies and develop a general framework for such connection in layered anisotropic media. We show that in general, the influences of lateral heterogeneity get accumulated from all layers via a recursive relationship according to the Fermat’s principle and can be approximately quantified in terms of the lateral derivatives of the layer interface surfaces and velocities. Based on the same general principle, we show that our approach can also be used to study the lateral heterogeneity effects on diffraction traveltime and its second-order derivative related to time-migration velocity. In this paper, we explicitly specify expressions for NMO and time-migration velocities with the influences from both types of heterogeneity suitable for 2-D data sets and also discuss possible extensions of the proposed theory to 3-D data sets and to parameters related to higher-order traveltime derivatives. Using numerical examples, we demonstrate that the proposed theory can lead to more accurate reflection and diffraction traveltime predictions in comparison with those obtained based on the 1-D assumption. Both the proposed theoretical framework and its numerical testing for forward traveltime computation presented in this study aid in understanding the effects from lateral heterogeneity on time-processing parameters and also serve as an important basis for designing an efficient technique to separate those influences in important processes such as Dix inversion for a more accurate subsurface model in the future.
Gene replacement therapy after neuropathy onset provides therapeutic benefit in a model of CMT1X
Authors: Kagiava A , Richter J , Tryfonos C , Karaiskos C , Heslegrave A J , Sargiannidou I , Rossor A M , Zetterberg H , Reilly M M , Christodoulou C , Kleopa K A 
Published: August 2019

Abstract
X-linked Charcot-Marie-Tooth disease (CMT1X), one of the commonest forms of inherited demyelinating neuropathy, results from GJB1 gene mutations causing loss of function of the gap junction protein connexin32 (Cx32). The aim of this study was to examine whether delayed gene replacement therapy after the onset of peripheral neuropathy can provide a therapeutic benefit in the Gjb1-null/Cx32 knockout model of CMT1X. After delivery of the LV-Mpz.GJB1 lentiviral vector by a single lumbar intrathecal injection into 6-month-old Gjb1-null mice, we confirmed expression of Cx32 in lumbar roots and sciatic nerves correctly localized at the paranodal myelin areas. Gjb1-null mice treated with LV-Mpz.GJB1 compared with LV-Mpz.Egfp (mock) vector at the age of 6 months showed improved motor performance at 8 and 10 months. Furthermore, treated mice showed increased sciatic nerve conduction velocities, improvement of myelination and reduced inflammation in lumbar roots and peripheral nerves at 10 months of age, along with enhanced quadriceps muscle innervation. Plasma neurofilament light (NEFL) levels, a clinically relevant biomarker, were also ameliorated in fully treated mice. Intrathecal gene delivery after the onset of peripheral neuropathy offers a significant therapeutic benefit in this disease model, providing a proof of principle for treating patients with CMT1X at different ages.
Tranexamic acid and convulsive seizures after off-pump coronary artery bypass surgery: the role of renal insufficiency
Authors: Hulde Nikolai , Zittermann Armin , Deutsch Marcus-Andre , von Dossow Vera , Gummert Jan F , Koster Andreas 
Published: August 2019

Abstract
There is evidence that, in adult cardiac surgical patients undergoing on-pump procedures, tranexamic acid (TXA) dose-dependently increases the risk of convulsive seizure (CS). We aimed to investigate whether a single TXA bolus of 1 g influences the risk of CS in patients who were operated on without the use of cardiopulmonary bypass. In 2249 propensity-score-matched pairs who underwent off-pump coronary artery bypass grafting with or without TXA administration, the risk of CS was 0.5% and 0.3% in the TXA and non-TXA groups, respectively (P = 0.36). In the subgroups of patients with estimated glomerular filtration rates <30, 30–60 and >60 ml/min/1.73 m2, the risk of CS in the TXA group was 2.8%, 1.2% and 0.4%, respectively (P = 0.002), and in the non-TXA group 0.0%, 0.0% and 0.3%, respectively (P = 0.36). The risk of stroke, in-hospital mortality and 30-day mortality did not differ significantly between study groups (P-value >0.05). Our data indicate that in patients undergoing off-pump coronary artery bypass grafting, a single TXA bolus of 1 g generally does not increase the risk of CS. However, the presence and extent of renal insufficiency have a very significant impact on the incidence of CS even after single-dose TXA.
Hypothalamic Responses to Cocaine and Food Cues in Individuals with Cocaine Dependence
Authors: Zhang Sheng , Zhornitsky Simon , Le Thang M , Li Chiang-Shan R 
Published: August 2019

Abstract

Background
Individuals with cocaine addiction are characterized by under-responsiveness to natural reinforcers. As part of the dopaminergic pathways, the hypothalamus supports motivated behaviors. Rodent studies suggested inter-related roles of the hypothalamus in regulating drug and food intake. However, few studies have investigated hypothalamic responses to drugs and food or related cues in humans.

Methods
We examined regional responses in 20 cocaine-dependent and 24 healthy control participants exposed to cocaine/food (cocaine dependent) and food (healthy control) vs neutral cues during functional magnetic resonance imaging. We examined the relationship between imaging findings and clinical variables and performed mediation analyses to examine the inter-relationships between cue-related activations, tonic cocaine craving, and recent cocaine use.

Results
At a corrected threshold, cocaine-dependent participants demonstrated higher activation to cocaine than to food cues in the hypothalamus, inferior parietal cortex, and visual cortex. Cocaine-dependent participants as compared with healthy control participants also demonstrated higher hypothalamic activation to food cues. Further, the extent of these cue-induced hypothalamic activations was correlated with tonic craving, as assessed by the Cocaine Craving Questionnaire, and days of cocaine use in the prior month. In mediation analyses, hypothalamic activation to cocaine and food cues both completely mediated the relationship between the Cocaine Craving Questionnaire score and days of cocaine use in the past month.

Conclusions
The results were consistent with the proposition that the mechanisms of feeding and drug addiction are inter-linked in the hypothalamus and altered in cocaine addiction. The findings provide new evidence in support of hypothalamic dysfunction in cocaine addiction.
Refined Scattering Diagrams and Theta Functions From Asymptotic Analysis of Maurer–Cartan Equations
Authors: Leung Naichung Conan , Ma Ziming Nikolas , Young Matthew B 
Published: August 2019

Abstract
We further develop the asymptotic analytic approach to the study of scattering diagrams. We do so by analyzing the asymptotic behavior of Maurer–Cartan elements of a (dg) Lie algebra constructed from a (not necessarily tropical) monoid-graded Lie algebra. In this framework, we give alternative differential geometric proofs of the consistent completion of scattering diagrams, originally proved by Kontsevich–Soibelman, Gross–Siebert, and Bridgeland. We also give a geometric interpretation of theta functions and their wall-crossing. In the tropical setting, we interpret Maurer–Cartan elements, and therefore consistent scattering diagrams, in terms of the refined counting of tropical disks. We also describe theta functions, in both their tropical and Hall algebraic settings, in terms of distinguished flat sections of the Maurer–Cartan-deformed differential. In particular, this allows us to give a combinatorial description of Hall algebra theta functions for acyclic quivers with nondegenerate skew-symmetrized Euler forms.
Patient-reported outcomes after open radical prostatectomy, laparoscopic radical prostatectomy and permanent prostate brachytherapy
Authors: Hashine Katsuyoshi , Kakuda Toshio , Iuchi Shunsuke , Tomida Ryotaro , Matsumura Masafumi 
Published: August 2019

Abstract

Objective
To assess patient-reported outcomes after open radical prostatectomy, laparoscopic radical prostatectomy and permanent prostate brachytherapy.

Methods
patient-reported outcomes were evaluated using Expanded Prostate Cancer Index Composite scores at baseline and 1, 3, 6, 12 and 36 months after treatment, respectively, using differences from baseline scores.

Results
Urinary function was the same in the three groups at baseline, but worse after surgery than after permanent prostate brachytherapy until 12 months, and similar after open radical prostatectomy and permanent prostate brachytherapy and better than after laparoscopic radical prostatectomy at 36 months. Urinary bother was significantly worse at 1 month after surgery, but better after open radical prostatectomy than after permanent prostate brachytherapy and laparoscopic radical prostatectomy at 3 months, after which symptoms improved gradually in all groups. Obstructive/irritative symptoms were worse after permanent prostate brachytherapy than after open radical prostatectomy at 36 months, and worse after laparoscopic radical prostatectomy until 6 months. Urinary incontinence was worse after surgery, particularly after 1 month. This symptom returned to the baseline level at 12 months after open radical prostatectomy, but recovery after laparoscopic radical prostatectomy was slower. Bowel function after permanent prostate brachytherapy was significantly worse than after surgery at 1 month and this continued until 6 months. Bowel bother was slightly worse at 3 and 6 months after permanent prostate brachytherapy compared to these time points after surgery.

Conclusion
Urinary function and bother were worst after laparoscopic radical prostatectomy, especially in the early postoperative phase, whereas urinary obstructive/irritative symptom, bowel function and bother were worse after permanent prostate brachytherapy. These findings are useful and informative for the treatment of patients with prostate cancer.
Hypoxia-Induced TGFBI as a Serum Biomarker for Laboratory Diagnosis and Prognosis in Patients with Pancreatic Ductal Adenocarcinoma
Authors: Yang Lingmin , Cui Ranliang , Li Yueguo , Liang Kai , Ni Min , Gu Yajun 
Published: August 2019

Abstract

Objective
To explore novel biomarkers for patients with pancreatic ductal adenocarcinoma (PDAC), from the perspective of tumor hypoxia.

Methods
We screened 29 differentially expressed and hypoxia-upregulated genes from the Oncomine database. A total of 12 secretory proteins that interact with hypoxia-inducible factor 1 (HIF-1A) were selected by STRING (protein-protein interaction networks). After excluding enzymes and collagens, insulin-like growth factor-binding protein 3 (IGFBP3), glycoprotein NBM (GPNMB), transforming growth factor–β-induced (TGFBI), and biglycan (BGN) were detected by sandwich enzyme-linked immunosorbent assay (ELISA) in patients with cancer and healthy control individuals.

Results
The serum level of TGFBI was significantly elevated in patients with PDAC, compared with healthy controls; the assay could discriminate among cases of PDAC in different clinical stages. The amount of TGFBI was significantly decreased after treatment. The combination of TGFBI and cancer antigen (CA) 19-9 was more accurate than TGFBI or CA 19-9 alone as diagnostic markers. Also, TGFBI might be used as a prognostic marker according to the PROGgeneV2 Pan Cancer Prognostics Database.

Conclusions
Serum TGFBI, combined with CA 19-9, offers higher diagnostic value than other methods for patients with PDAC. Also, TGFBI might be used as a prognostic marker.
Probing quasar winds using intrinsic narrow absorption lines
Authors: Culliton Chris , Charlton Jane , Eracleous Mike , Ganguly Rajib , Misawa Toru 
Published: August 2019

ABSTRACT
We use the spectra of 73 quasars (1.5 ≲ z ≲ 5) from the VLT UVES archive to catalogue and study narrow absorption lines (NALs) that are physically associated with (intrinsic to) the quasars. We identify 410 NAL systems containing C iv, N v, and/or Si iv doublets. Based on the assumption that only systems intrinsic to the quasar can exhibit partial coverage of the background source(s), we identify 34 reliably intrinsic NAL systems and 11 systems that are potentially intrinsic, as well as 4 mini-broad absorption lines (BALs) and 1 BAL. The minimum fraction of quasars with at least one intrinsic system is shown to be 38 per cent. We identify intrinsic NALs with a wide range of properties, including apparent ejection velocity, coverage fraction, and ionization level. There is a continuous distribution of properties, rather than discrete families, ranging from partially covered C iv systems with black Ly α and with a separate low-ionization gas phase to partially covered N v systems with partially covered Ly α and without detected low-ionization gas. Even more highly ionized associated and intrinsic absorption systems (O vi, Ne viii, and Mg x doublets) have been presented in separate studies; these may represent an extension of the above sequence. We also use the properties of the NALs in conjunction with recent models of accretion disc winds that predict the origins of the absorbing gas in order to determine the model that best characterizes our sample. Additionally, we construct a model describing the spatial distributions, geometries, and varied ionization structures of intrinsic NALs.
Constraining scatter in the stellar mass–halo mass relation for haloes less massive than the Milky Way
Authors: Allen Magdelena , Behroozi Peter , Ma Chung-Pei 
Published: August 2019

ABSTRACT
Most galaxies are hosted by massive, invisible dark matter haloes, yet little is known about the scatter in the stellar mass–halo mass relation for galaxies with host halo masses Mh ≤ 1011M⊙. Using mock catalogues based on dark matter simulations, we find that two observable signatures are sensitive to scatter in the stellar mass–halo mass relation even at these mass scales; i.e. conditional stellar mass functions and velocity distribution functions for neighbouring galaxies. We compute these observables for  179,373 galaxies in the Sloan Digital Sky Survey (SDSS) with stellar masses M* &gt; 109 M⊙ and redshifts 0.01 &lt; z &lt; 0.307. We then compare to mock observations generated from the Bolshoi-Planck dark matter simulation for stellar mass–halo mass scatters ranging from 0 to 0.6 dex. The observed results are consistent with simulated results for most values of scatter (&lt;0.6 dex), and SDSS statistics are insufficient to provide firm constraints. However, this method could provide much tighter constraints on stellar mass–halo mass scatter in the future if applied to larger data sets, especially the anticipated Dark Energy Spectroscopic Instrument Bright Galaxy Survey. Constraining the value of scatter could have important implications for galaxy formation and evolution.
Photometric redshifts for X-ray-selected active galactic nuclei in the eROSITA era
Authors: Brescia M , Salvato M , Cavuoti S , Ananna T T , Riccio G , LaMassa S M , Urry C M , Longo G 
Published: August 2019

ABSTRACT
With the launch of eROSITA (extended Roentgen Survey with an Imaging Telescope Array), successfully occurred on 2019 July 13, we are facing the challenge of computing reliable photometric redshifts for 3 million of active galactic nuclei (AGNs) over the entire sky, having available only patchy and inhomogeneous ancillary data. While we have a good understanding of the photo-z quality obtainable for AGN using spectral energy distribution (SED)-fitting technique, we tested the capability of machine learning (ML), usually reliable in computing photo-z for QSO in wide and shallow areas with rich spectroscopic samples. Using MLPQNA as example of ML, we computed photo-z for the X-ray-selected sources in Stripe 82X, using the publicly available photometric and spectroscopic catalogues. Stripe 82X is at least as deep as eROSITA will be and wide enough to include also rare and bright AGNs. In addition, the availability of ancillary data mimics what can be available in the whole sky. We found that when optical, and near- and mid-infrared data are available, ML and SED fitting perform comparably well in terms of overall accuracy, realistic redshift probability density functions, and fraction of outliers, although they are not the same for the two methods. The results could further improve if the photometry available is accurate and including morphological information. Assuming that we can gather sufficient spectroscopy to build a representative training sample, with the current photometry coverage we can obtain reliable photo-z for a large fraction of sources in the Southern hemisphere well before the spectroscopic follow-up, thus timely enabling the eROSITA science return. The photo-z catalogue is released here.
Partitioning the Universe into gravitational basins using the cosmic velocity field
Authors: Dupuy Alexandra , Courtois Helene M , Dupont Florent , Denis Florence , Graziani Romain , Copin Yannick , Pomarède Daniel , Libeskind Noam , Carlesi Edoardo , Tully Brent , Guinet Daniel 
Published: August 2019

ABSTRACT
This letter presents a new approach using the cosmic peculiar velocity field to characterize the morphology and size of large-scale structures in the local Universe. The algorithm developed uses the three-dimensional peculiar velocity field to compute flow lines, or streamlines. The local Universe is then partitioned into volumes corresponding to gravitational basins, also called watersheds, among the different end points of the velocity flow lines. This new methodology is first tested on numerical cosmological simulations, used as benchmark for the method, and then applied to the Cosmic-Flows project observational data in order to pay particular attention to the nearby superclusters including ours. More extensive tests on both simulated and observational data will be discussed in an accompanying paper.
Global review of heart health claims for oat beta-glucan products
Authors: Mathews Rebecca , Kamil Alison , Chu YiFang 
Published: August 2019

AbstractCoronary heart disease (CHD) is the leading cause of death globally. Consumption of whole grains and cereal fiber, as part of a healthy diet, can lower the risk of CHD. Health claims on food products are effective in helping consumers select healthful diets. The US Food and Drug Administration was the first to approve a health claim, in 1997, between beta-glucan soluble fiber from whole oats, oat bran, and whole oat flour and reduced risk of CHD. Only a few countries have approved similar claims. Since 1997, a significant amount of additional evidence has been published on the relationship between oat beta-glucan and CHD. To assist other jurisdictions in potentially utilizing this claim, the full extent of data that supports this claim (ie, the evidence utilized by the US Food and Drug Administration to substantiate the claim, as well as the results of 49 clinical trials published since 1997) are reviewed here. The complexities involved in authoring evidence-based health claims, including the impact of processing on beta-glucan cholesterol-lowering efficacy in approving eligible beta-glucan products, are also discussed.
Stereoencephalography Electrode Placement Accuracy and Utility Using a Frameless Insertion Platform Without a Rigid Cannula
Authors: D’Agostino Erin , Kanter John , Song Yinchen , Aronson Joshua P 
Published: August 2019

Abstract

BACKGROUND
Implantation of depth electrodes to localize epileptogenic foci in patients with drug-resistant epilepsy can be accomplished using traditional rigid frame-based, custom frameless, and robotic stereotactic systems.

OBJECTIVE
To evaluate the accuracy of electrode implantation using the FHC microTargeting platform, a custom frameless platform, without a rigid insertion cannula.

METHODS
A total of 182 depth electrodes were implanted in 13 consecutive patients who underwent stereoelectroencephalography (SEEG) for drug-resistant epilepsy using the microTargeting platform and depth electrodes without a rigid guide cannula. MATLAB was utilized to evaluate targeting accuracy. Three manual coordinate measurements with high inter-rater reliability were averaged.

RESULTS
Patients were predominantly male (77%) with average age 35.62 (SD 11.0, range 21-57) and average age of epilepsy onset at 13.4 (SD 7.2, range 3-26). A mean of 14 electrodes were implanted (range 10-18). Mean operative time was 144 min (range 104-176). Implantation of 3 out of 182 electrodes resulted in nonoperative hemorrhage (2 small subdural hematomas and one small subarachnoid hemorrhage). Putative location of onset was identified in all patients. We demonstrated a median lateral target point localization error (LTPLE) of 3.95 mm (IQR 2.18-6.23), a lateral entry point localization error (LEPLE) of 1.98 mm (IQR 1.2-2.85), a target depth error of 1.71 mm (IQR 1.03-2.33), and total target point localization error (TPLE) of 4.95 mm (IQR 2.98-6.85).

CONCLUSION
Utilization of the FHC microTargeting platform without the use of insertion cannulae is safe, effective, and accurate. Localization of seizure foci was accomplished in all patients and accuracy of depth electrode placement was satisfactory.
Chairing UK Select Committees: Walking Between Friends and Foes
Authors: Crewe Emma , Sarra Nicholas 
Published: August 2019

AbstractIn this article, we aim to look at the political, social and emotional world created by the UK’s House of Commons select committees and the part played by their chairs. Drawing upon the theoretical traditions of political anthropology (Spencer (2004, Anthropology, Politics and the State: Democracy and Violence in South Asia, Cambridge, Cambridge University Press)), group analytical theory (Foulkes (1948, Group Analytic Psychotherapy: Method and Principles, London, William Heinemann Medical Books)) and pragmatic philosophy (Dewey (1922, Human Nature and Conduct: An Introduction to Social Psychology, New York, NY, Henry Holt and Company)), we view the experience of individuals as relational, created in their interaction with other individuals and groups. The context is that select committees aspire to consider evidence impartially and work cohesively to hold government to account. Our focus is on the political work of the chairs of Commons’ select committees. Committee chairs, members and staff are constrained by the architecture, rules and rituals in their bid to achieve plausibility, but at the same time find the room to express individuality in the ways that they manage emotions and communicate with others through words, silence, bodily movements or facial expressions. By embodying the committee, and mediating between those involved, the work of chair involves walking between friends and enemies—forming alliances, dealing with disagreements and disciplining the unruly—to create the impression that select committees are above party politics.