bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative in vivo studying of potential antineoplastic properties among of amino-acid derivative glycosides of the indolocarbazole (detailed report)
Authors: Golubeva I. S. , Goryunova O. V. , Yavorskaya N. P. 
Published: November 2018

Introduction.The existence of the active metabolite (amino acid) residue in the of an indolocarbazole molecule changes physical-chemical and pro-medicinal properties of aminoacid derivatives glycosides of indolocarbazole. The computer method has earlier foretold low probability of their cytotoxic activity in vitro that was confirmed in the MTT-test on 5 lines of tumor cells. The same computer method predicted significant probability of antineoplastic activity of aminoacid derivatives glycosides of indolocarbazole in vivo that demands the experimental check. Purpose of the study– assessment of aminoacid derivatives glycosides of indolocarbazole as potential antitumor medications.Materials and methods.The research of antineoplastic activity of aminoacid derivatives glycosides of indolocarbazole was performed on mice tumoral models – cervical cancer СС5. Abdominal injections were made to CBA/Lac mice 5 times a day with 24 h interval. Observation of animals was continued till their death. The antineoplastic effect of medicines was estimated according to tumor growth inhibition, increase in life expectancy of experiental mice in comparison with control animals.Results.The optimum dose for this number of compounds, equal to 100 mg/kg is titrated. The antineoplastic activity of aminoacid derivatives glycosides of indolocarbazole on the model СС5 is estimated.Conclusions.On the basis of the obtained data the expanded research of antineoplastic properties of the selected 5 aminoacid derivatives glycosides of indolocarbazole is supposed to perform in vivo.
Expression rate of ALK tyrosine kinase and TAG-72 oncoprotein in primary skin melanoma
Authors: Titov K. S. , Rotin D. L. , Kazakov A. M. , Micheeva O. U. , Telezhnikova I. M. , Ryabchikov D. A. 
Published: November 2018

Objective.Determine the frequency of occurrence of tyrosine kinase expression of the mutated ALK and TAG-72 gene among patients with primary melanoma of the skin, to identify their association with a number of histological parameters, and to assess the diagnostic value of the determination of ALK and TAG-72.Materials and methods.Paraffin blocks with surgical material from 40 patients with primary skin melanoma. For routine histological examination, the material was fixed with 10 % neutral formalin for 24 h, poured into paraffin, sections were prepared with a thickness of 4–5 μm, stained with hematoxylin and eosin. IHC study with monoclonal antibodies D57.3 to ALK was performed on an immunostender – Ventana, with antibodies B72.3 to TAG-72 – on Thermo Fischer. As a detection system used: Envision – for TAG-72 and Ventana – for ALK.Results.ALK mutation was detected in 7 (12 %), TAG-72 – 4 (10 %) cases. Evaluation of the correlation force between the presence of ALK and TAG-72 showed a direct average coupling strength (correlation coefficient was 0.31). A direct correlation of the mean force between the presence of TAG-72 oncoprotein, ALK mutation and ulceration in the patient was found – the correlation coefficient was 0.53 and 0.68, respectively. There was a statistically significant association between the presence of ALK and lymphoid infiltration, which in most cases (57 %) was pronounced (p <0.05).Conclusion.Comparing the positive sign of the expression of ALK – 17.5 % and TAG-72 – 10 %, and the positive of their simultaneous detection – 7.5 %, it can be concluded that further studies to determine their diagnostic value are promising. The presence of severe lymphoid infiltration in ALK-positive patients claims a diagnostic value in primary skin melanoma.
Motivación y realidad aumentada: Alumnos como consumidores y productores de objetos de aprendizaje. Motivation and augmented reality: Students as consumers and producers of learning objects
Authors: Marín-Díaz Verónica , Cabero-Almenara Julio , Gallego-Pérez Oscar Manuel 
Published: November 2018

La incorporación de herramientas digitales a la enseñanza supone en un gran número de casos una modificación de la actitud del estudiante hacia los contenidos. Así encontramos como la Realidad Aumentada, poco a poco se ha ido incorporando a las aulas, provocando una revolución en la forma de entender las materias a estudiar, generando una mayor motivación por parte del alumnado por desarrollar su proceso de aprendizaje. En el este artículo se presentan los resultados de la aplicación de la RA como recurso potenciador de la motivación por el aprendizaje en un grupo de alumnos de la Universidad de Sevilla del grado de Pedagogía y que cursaban la materia Tecnología Educativa. A través del modelo de Keller (1983) se ha comprobar si la utilización de esta tecnología propiciaba una mayor motivación hacia el estudio. Tras el desarrollo en el aula de una acción de innovación docente, donde los alumnos se convirtieron en consumidores y creadores de materiales y la posterior aplicación del modelo propuesto, se pudo concluir a través de los resultados alcanzados que los estudiantes participantes mostraron una mayor motivación hacia el aprendizaje de los contenidos de la materia en la que de desarrollo la investigación
Comparative Study of 3D Simulation and Experiment on Stator MPPUA of Generator under FWISC Faults with Different Degrees
Authors: He 1 Yu-Ling , Meng 1 Qing-Fa , Wang 2 Ping , Xu 1 Ming-Xing 
Published: November 2018

In order to study the impacts of the stator magnetic pull per unit area (MPPUA) characteristics under different field winding inter-turn short-circuit (FWISC) degrees in generator, comparative study of 3D numerical simulations and experiments are respectively taken to calculate the quantitative data of stator MPPUA by finite-element method (FEM) in this paper. Firstly, the nature exciting force of stator vibration, which is called MPPUA, is carried out. Then simulations data on MPPUA under normal condition and different short-circuit degrees are obtained. Finally, the variation rules of MPPUA characteristics by experiments under different conditions are studied. The results show that in normal condition the main harmonic components of MPPUA consist of only 6th-harmonic component. However, the occurrence of FWISC will bring in extra 1st, 2nd, 3rd, 4th and 5th-harmonic components to MPPUA. Meanwhile, with the increasing of the rotor short circuit degrees, the amplitudes of 1st, 2nd, 3rd, 4th and 5th-harmonic components will present an increasing trend. However, the amplitudes of 6th-harmonic component will present a decrease trend.
In the era of endo-venous ablation of varicose veins, is surgery still competitive?
Authors: Elmallah Ahmed S. , Alkhateeb Yehia M. , Elmallah Said I. 
Published: November 2018

Background: There are different evolving minimally invasive surgical options for varicose veins (VV) treatment. This study compared Endo-venous Laser Ablation (EVLA) and foam sclerotherapy Vs high tie and multiple phlebectomy / ligation without vein stripping.Methods: 185 lower limbs with primary VV and sapheno-femoral junction (SFJ)incompetence were included. Patients were divided into two groups. Group A: 85 limbs in 78 patients (4 had chronic venous ulcers) were treated by EVLA & foam sclerotherapy under tumescent anesthesia. Group B: 100 limbs in 100 patients (5 had chronic venous ulcers) were treated by high tie and multiple phlebectomy/ ligation under local anesthesia. All patients had duplex ultrasound preoperative and 4 weeks and 1 year postoperatively. Postoperative outpatient follow-up was 4 weeks, 3, 6 and 12 months.Results: All procedures were successful. Early postoperative recurrence in 3 limbs (3.52%) in EVLA and no early recurrence in group B. Patients with venous ulcers healed within 3-5 weeks in both groups. Postoperative pigmentation was higher in group B. Mean time of procedure was 60-90 min and 60-150 min respectively. Significant pain in first week was more in group A (40 patients) than group B (22 patients) p<0.05. No DVT, wound infection, permanent nerve affection nor skin burn was recorded in both groups. Return to normal activities was quicker in Group B compared to group A but mean cost per limb was higher in Group B (1000 -1500 US $) versus Group A (500-750 US$).Conclusions: Both procedures are effective and safe in treating varicose veins. Minimally invasive surgery was less costly, more postoperative pain and was associated with longer operative time. EVLA was associated with more postoperative pigmentation and 1 year VV recurrence.
Looking Beyond Institutional Boundaries: Examining Adults’ Experience of Choosing Online as Part of Their Post-Secondary Studies
Authors: Rasmussen Kari 
Published: November 2018

This research focused beyond the student, course, program, or institution by examining the conceptions of adults at the moment in time that they evaluated their choice to engage in furthering their post-secondary education by examining the possibilities provided through online learning. To capture their experience, not as students but as members of society, a practice of care framework, adapted from Tronto’s (1993) work, was utilized as a theoretical framework. The use of this framework acknowledges that the practice of care is present in the lives of every human being and that each human being has received and/or provided care as part of their lived experience. A phenomenographical qualitative approach was the basis for the design of this project which allowed for the identification of the commonalities and variations of the described experience. All described experiences illustrated the balancing of needs, wants, and responsibilities, these descriptions included recognition of care of one’s self, one’s family, and one’s community. The variation could be described as an expansion of the recognition of care, that is the focus of care expanded from self to family and then from family to community. This expansion occurred only in those described experiences that showed a strong conception of themselves within the previous category. The findings show that the choice to access online courses and/or programs provides possibilities for many adults that wish to continue their education but only if the educational environment can move away from its institutional centric perspective.
Responses of Linoleic and High Oleic Type Sunflower Varieties (Helianthus Annuus L.) to Nitrogen and Potassium Applications
Authors: ÇELİK Hakan , ÖREN Gürcan 
Published: November 2018

Objective: The study was conducted to determine the effects of nitrogen (N) and potassium (K) on dry matter and some nutrient elements uptake of linoleic and high-oleic type sunflower varieties.Material and Methods: A greenhouse experiment was carried out in randomized factorial design with three replicates, 0, 16, 32, 48, and 64 mg kg-1 N and 0, 24, and 48 mg kg-1 K were applied.Results: Dry matter and nutrient uptake of sunflower varieties increased with nitrogen (p&lt;0.01), however decreased with potassium. The highest amounts were obtained from 32 mg kg-1 N dose and ESGrafic CL variety.Conclusion: High-oleic type sunflower varieties have resulted in more fertilizer requirements.
Mercimek (Lens culinaris M.) DEHYDRATION RESPONSIVE ELEMENTBINDING2A (DREB2A) Geninin Kuraklık Stresi Koşullarındaki İfadesinin Belirlenmesi
Authors: BAKIR Melike 
Published: November 2018

Amaç: Dehydration responsive element binding (DREB) proteinleri, bitkilerde strese yanıt ve sinyal iletiminde önemli rol oynarlar. Bu çalışmada, DREB gen ailesinin üyesi olan ve LcDREB2A olarak isimlendirilen mercimek (Lens culinaris M.) DREB2A geninin kısmi cDNA’sı izole edilmiş ve kuraklık stresi ile ilişkisi belirlenmiştir.Materyal ve Metot: Kuraklık stresi ve LcDREB2A gen ifadesi arasındaki ilişkiyi anlamak için, 2 hafta süre ile yetiştirilen mercimek fidelerine 6, 13 ve 20 gün süre ile sulamama şeklinde kuraklık stresi uygulanmıştır. Kök ve yapraklarda meydana gelen gen ifadesi değişimleri eş zamanlı kantitatif PCR (Real-time qPCR) ile belirlenmiştir.Bulgular: LcDREB2A gen ifadesi, Fırat87 ve Özbek çeşidinin yapraklarında artan kuraklık stresi ile artmış ve kuraklığın 20. gününde en yüksek seviyeye ulaşmıştır. Diğer taraftan Özbek çeşidinin köklerinde gen ifadesi seviyesi 6. günde en yüksek seviyeye ulaşırken 13. günde azalmış ve 20. günde tekrar artış göstermiştir. Fırat87 çeşidinde ise, artan kuraklık stresi ile birlikte düzenli bir artış görülmüş ve 20. günde en yüksek seviyeye ulaşmıştır.Sonuç: LcDREB2A geninde gözlenen doku spesifik gen ifadesi profili, bu transkripsiyon faktörünün mercimek bitkisinde kuraklık stresindeki rolünü ve kompleks regülasyonunu göstermektedir.
Rigless Abandonment with Bismuth and Thermite
Authors: Carragher Paul , Fulks Jeff 
Published: November 2018

Abstract
In today's oil and gas industry, successful well abandonment is becoming increasingly more important, particularly in subsea wells. Proper abandonment of a well the first time not only saves the operator time and money, it also ensures that our environment is not negatively impacted. To accomplish this, the wells must have gas tight seals placed in them that that will maintain their integrity long after the well has been abandoned. A new way to create these gas tight seals is to combine the unique properties of bismuth with the heat capacity of thermite.
Cap Rock Restoration in Well Abandonment: Fit-for-Purpose Well Abandonment Design through Workflow Optimization and Integrated Assessment
Authors: Kueh Jing Zhi , Hassani Hamed , B Zamzuri Mohd Dzulfahmi , B Johan Ahamd Luqman , B Zainal Abidin M Zakwan , B Abdussalam Khomeini , B Yusop Zainuddin , B A Razak M Anas 
Published: November 2018

Abstract
Due to sharp oil price downturn in last few years, operators have been looking for ways to reduce operating expenses, especially on non producing assets. Well abandonment is proposed for non producing wells to reduce long term operating expenses. For well abandonment, traditional practice was well abandonment at reservoir level, with the purpose of securing entire well integrity as safety was the main concern. However, due to huge amount of time and cost associated to traditional well abandonment method, operators have been looking for optimization on well abandonment.
Field B is located in offshore Sarawak, and has been producing since 1968. Currently, Field B is in second half of its life cycle, and some wells and facilities are currently planned for decommissioning and abandonment. Well abandonment studies were initiated for 3 wells in Field B, with the purpose of reducing long term operating expenditures and minimize operation complexity. The studies are conducted by integrated team, consists of Petrophysicist, Reservoir Engineer, Production Technologist and Workover Engineer.
Well abandonment studies adopted integrated assessment approach, with the focus of reducing the time and cost related to well abandonment without jeopardizing safety requirements. As results, proposed abandonment intervals are significantly reduced compared to what has been planned initially. With simplified well abandonment plan, fit-for-purpose rig is used, and well abandonment operation cost is reduced with reduction in rig day rate. This paper will chronicle well abandonment optimization through workflow optimization and integrated assessment for well abandonment proposal.
Converted Barge for Wellhead Platform Decommissioning
Authors: Yimtae Den , Aimcharoenchaiyakul Manit , Uiyyasathian Sarayut , Svasti-xuto Maythus , Chanvanichskul Chatawut 
Published: November 2018

Abstract
This paper presents an alternative method for decommissioning offshore wellhead platform using converted flat top barge as decommissioning barge. The barge shall have capability to self-decommissioning topside and jacket and transportation to disposal premises. The key advantage for this propose new concept is to eliminate using of heavy derrick-crane vessel for all decommissioning activities, this can help to reduce cost for decommissioning in significant magnitude and also reduce marine hazards due to heavy lift handling. The barge will be installed with accommodation module, special tools and equipment such as mooring system, reverse float-over lifting with heave-compensation system & skidding appliances, jacket bottom lifting appliances and etc. in order to perform decommissioning activities under opensea environment with only minimal assist from marine support vessel. The decommissioning barge concept is designed to suit with various sizes of wellhead platform. Extensive engineering study has been performed in term of naval architect and structure engineering to proof feasibility of decommissioning barge concept and the existing platform located in Gulf of Thailand where is prone to Typhoon extreme sea condition. The study result shows that modify barge is feasible to perform decommissioning of various sized wellhead platforms. Applicable worldwide offshore and Southeast Asian fields, present many similar platforms where this innovative tools can be used to make an economy of scale in the removal operations. The feasibility study also include scope of explore opportunity to further improvement in term of flexible operation and cost saving. The following two options are performed the high level feasibility study and cost sensitivity with positive result outcomes. Option 1 -Decommissioning barge with self-propelled systemOption 2 -Decommissioning barge with self-propelled with control stationkeeping capabilities
In term of cost saving, sensitivity study to compare the cost with conventional method is perform. Based on decommissioning execution over an entire service life, the decommissioning barge can gain cost saving over 23%.
p-Trifluoroacetophenone Oxime Ester Derivatives: Synthesis, Antimicrobial and Cytotoxic Evaluation and Molecular Modeling Studies
Authors: Bozbey İrem , Sari Suat , Şalva Emine , Kart Didem , Karakurt Arzu 
Published: November 2018

Background:
Azole antifungals are among the first-line drugs clinically used for the
treatment of systemic candidiasis, a deadly type of fungal infection that threatens mostly immunecompromised
and hospitalized patients. Some azole derivatives were also reported to have
antiproliferative effects on cancer cells.

Objective:
In this study, 1-(4-trifluoromethylphenyl)-2-(1H-imidazol-1-yl)ethanone (3), its oxime
(4), and a series of its novel oxime ester derivatives (5a-v) were synthesized and tested for their in
vitro antimicrobial activities against certain ATCC standard strains of Candida sp. fungi and
bacteria. The compounds were also tested for their cytotoxic effects against mouse fibroblast and
human neuroblastoma cell lines. Molecular modeling studies were performed to provide insights into
their possible mechanisms for antifungal and antibacterial actions.

Methods:
The compounds were synthesized by the reaction of various oximes with acyl chlorides.
Antimicrobial activity of the compounds was determined according to the broth microdilution
method. For the determination of cytotoxic effect, we used MTS assay. Molecular docking and
QM/MM studies were performed to predict the binding mechanisms of the active compounds in the
catalytic site of C. albicans CYP51 (CACYP51) and S. aureus flavohemoglobin (SAFH), the latter
of which was created via homology modeling.

Results:
5d, 5l, and 5t showed moderate antifungal activity against C. albicans, while 3, 5c, and 5r
showed significant antibacterial activity against Staphylococcus aureus and Pseudomonas
aeruginosa. Most of the compounds showed approximately 40-50% inhibition against the human
neuroblastoma cells at 100 µM. In this line, 3 was the most potent with an IC50 value of 82.18 μM
followed by 5a, 5o, and 5t. 3 and 5a were highly selective to the neuroblastoma cells. Molecular
modelling results supported the hypothesis that our compounds were inhibitors of CAYP51 and
SAFH.

Conclusion:
This study supports that oxime ester derivatives may be used for the development of
new antimicrobial and cytotoxic agents.
Identification of Novel Pancreatic Lipase Inhibitors UsingIn SilicoStudies
Authors: Panwar Umesh , Singh Sanjeev Kumar 
Published: November 2018

Background:Obesity is well known multifactorial disorder towards the public health concern in front of the world. Increasing rates of obesity are characterized by liver diseases, chronic diseases, diabetes mellitus, hypertension and stroke, improper function of the heart, reproductive and gastrointestinal diseases, and gallstones. An essential enzyme pancreatic lipase recognized for the digestion and absorption of lipids can be a promising drug target towards the future development of antiobesity therapeutics in the cure of obesity disorders.Objective:The purpose of present study is to identify an effective potential therapeutic agent for the inhibition of pancreatic lipase.Methods:A trio of in-silico procedure of HTVS, SP and XP in Glide module, Schrodinger with default parameters, was applied on Specs databases to identify the best potential compound based on receptor grid. Finally, based on binding interaction, docking score and glide energy, selected compounds were taken forward to the platform of IFD, ADME, MMGBSA, DFT, and MDS for analyzing the ligands behavior into the protein binding site.Results:Using in silico protocol of structure-based virtual screening on pancreatic lipase top two compounds AN-465/43369242 & AN-465/43384139 from Specs database were reported. The result suggested that both the compounds are competitive inhibitors with higher docking score and greatest binding affinity than the reported inhibitor.Conclusion:We anticipate that results could be future therapeutic agents and may present an idea toward the experimental studies against the inhibition of pancreatic lipase.
Narrativa, política e vida social: do folhetim à ficção seriada televisiva
Authors: Marques Angela Cristina Salgueiro 
Published: November 2018

Este artigo pretende evidenciar as articulações entre a narrativa, a política e a vida social, conferindo especial importância à linguagem ficcional e seu impacto na transposição de dilemas privados à esfera pública de debate.
Para tanto, estruturamos o texto em três partes. A primeira busca recuperar os principais aspectos da teoria da Indústria Cultural, apontando suas insuficiências
em reconhecer a) a capacidade crítica e reflexiva dos públicos com relação aos produtos culturais de massa e b) a potência da forma narrativa para a organização das identidades, das experiências coletivas sociais e das questões políticas. A segunda parte visa apontar a narrativa ficcional - desde
o romance-folhetim até à ficção seriada televisiva - como fonte de elementos que nos auxilia a estruturamos nossa experiência no mundo, ao mesmo tempo em que nos permite conferir sentido à nossa própria história de vida. Na
terceira parte, evidenciamos o papel exercido pela narrativa na constituição de processos de tematização e resolução de problemas na esfera pública.
Mànya Millen
Authors: Pena Felipe , Moutinho Marcelo 
Published: November 2018

"Acho importante ter livros que não Sejam nem eruditos,
nem tão best sellers, que façam o tal caminho cio meio. Esses
aí são capazes de formar leitores, no sentido da frequência e
da assiduidade da leitura.
Precisamos de um grupo cio meio que seja representativo."