bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Performance in the Physical Medicine and Rehabilitation Part II Certification Oral Examination Based On Milestone Ratings
Authors: Francisco Gerard E. , Raddatz Mikaela , Yamazaki Kenji , Sabharwal Sunil , Kirksey Keneshia , Kinney Carolyn , Holmboe Eric 
Published: December 2024

ABSTRACT
The Accreditation Council for Graduate Medical Education (ACGME) introduced the Milestones to document learner development within a competency-based framework. On the other hand, board certifying examinations serve as a summative evaluation of a learner’s readiness for independent medical practice. Scores in Part I of the American Board of Physical Medicine and Rehabilitation (ABPMR) examination, which measures medical knowledge, has been shown to correlate only with Milestones ratings in medical knowledge. We hypothesized that combined ratings of various Milestone competencies can predict subsequent performance in related ABPMR Part II certifying examination domains. Milestones data and ABPMR Part II examination scores of trainees in 3-yr PM&R residency programs in the United States from academic years (AY) 2014-2016 who sat for the ABPMR Parts I and II Examinations, immediately after completion of training, were reviewed. Regression analysis showed that Milestone sub-competencies, alone or in combination, did not correlate with Part II domain scaled scores. Medical Knowledge was the only Milestone sub-competency that was correlated with performance in the ABPMR Part I certifying examination. This current study found that no similar association exists between any of the Milestones Competencies and the ABPMR Part II certifying examination, suggesting that the two assessment tools measure different attributes.
High-intensity interval training effects on people with multiple sclerosis; a systematic review and meta-analyses for exercise capacity and fatigue
Authors: Martín-Núñez Javier , Gómez de Castro Sheila , Heredia-Ciuró Alejandro , Navas-Otero Alba , Cabrera-Martos Irene , Ortiz-Rubio Araceli , Valenza Marie Carmen 
Published: December 2024

Abstract

Objective
This study was to examine the effects of high-intensity interval training (HIIT) interventions on exercise capacity and fatigue in people with MS.

Design
We performed a systematic review and meta-analysis. PubMed/Medline, Web of Science, Scopus and Google Scholar databases were systematically searched from inception to January 2024. We reviewed randomized controlled trials (RCTs) that focused their intervention on HIIT for people with MS to improve exercise capacity or fatigue. Two researchers performed the search process independently in the different databases and assessed methodological quality and risk of bias.

Results
Eleven studies were included in the systematic review and seven of them were meta-analyzed. The overall pooled effect favored HIIT interventions in improving exercise capacity (SMD = 0.29; 95% CI = 0-05,0.53; p = 0.02) and reducing fatigue (SMD = -0.26; 95% CI = -0.50, -0.02; p = 0.03) in people with MS. We generally found a low risk of bias and a good methodological quality.

Conclusion
The results of this review and meta-analysis provide evidence that HIIT interventions improved and reduced fatigue in people with MS. HIIT intervention may be a good option to improve exercise capacity and reduce fatigue of these people.
All-Atom Protein Generation with Latent Diffusion
Authors: Lu Amy X. , Yan Wilson , Robinson Sarah A. , Kelow Simon , Yang Kevin K. , Gligorijevic Vladimir , Cho Kyunghyun , Bonneau Richard , Abbeel Pieter , Frey Nathan C. 
Published: December 2024

AbstractWhile generative models hold immense promise for protein design, existing models are typically backbone-only, despite the indispensable role that sidechain atoms play in mediating function. As prerequisite knowledge, all-atom 3D structure generation require the discrete sequence to specify sidechain identities, which poses a multimodal generation problem. We proposePLAID(ProteinLatent InducedDiffusion), which samples from thelatent spaceof a pre-trained sequence-to-structure predictor, ESMFold. The sampled latent embedding is then decoded with frozen decoders into the sequence and all-atom structure. Importantly,PLAID only requires sequence input during training, thus augmenting the dataset size by 2-4 orders of magnitude compared to the Protein Data Bank. It also makes more annotations available for functional control. As a demonstration of annotation-based prompting, we perform compositional conditioning on function and taxonomy using classifier-free guidance. Intriguingly, function-conditioned generations learn active site residue identities, despite them being non-adjacent on the sequence,andcan correctly place the sidechains atoms. We further show that PLAID can generate transmembrane proteins with expected hydrophobicity patterns, perform motif scaffolding, and improve unconditional sample quality for long sequences. Links to model weights and training code are publicly available at github.com/amyxlu/plaid.
PHENOTYPIC CHARACTERIZATION AND BACTERIAL INTERACTIONS OF THE COMPLEX MICROBIAL POPULATION IN URINARY DOUBLE-J CATHETERS
Authors: Farizano Juan Vicente , Castagnaro Emilia , Arroyo-Egea Julián , Aparicio Juan Daniel , Vallejo Cecilia , Hebert Elvira María , Saavedra Lucila , Rapisarda Viviana Andrea , Villegas Josefina María , Grillo-Puertas Mariana 
Published: December 2024

AbstractCatheter-associated urinary tract infections (CAUTIs) are a major cause of morbidity in healthcare settings, often linked to the colonization of catheters by diverse bacterial species. This study aimed to characterize 27 clinical uropathogenic isolates obtained from double-J catheters through phenotypic and genotypic assays. The isolated species included,Staphylococcusspp.,Enterococcus faecalis,Klebsiella pneumoniae,Escherichia coliandBacillusspp. These isolates were evaluated for biofilm formation, production of extracellular components such as cellulose and amyloid-like fibers, motility, hemolytic capacity, siderophore production, stress tolerance, and antibiotic resistance profiles. The findings revealed thatE. coli,S. aureus,B. subtilisisolates exhibited strong biofilm formation and robust extracellular matrix production, features that contribute to their persistence in catheter environments. Acid pH and oxidative stress tolerance results indicated a differential strain response even within the same genus. Additionally, multidrug resistance (MDR) was observed in several isolates, especially inK. pneumoniaandE. faecalis, correlating with their biofilm-forming capacities. Co-cultures studies demonstrated synergistic interactions between the co-isolated pair, particularly withBacillusspp. enhancing biofilm formation in static condition. The interaction results indicate the importance of investigating the potential clinical relevance ofBacillusspp., even though they are not traditionally considered human pathogens. These results provide critical insights into the pathogenic mechanisms and survival strategies of several uropathogens in CAUTI, emphasizing the need for targeted therapeutic interventions to prevent recurrent infections and manage antibiotic resistance.ImportanceCatheter-associated urinary tract infections (CAUTIs) are a persistent challenge in healthcare due to their association with biofilm-forming bacteria that resist treatments. To investigate the complexity of microbial population of CAUTI, we provide an in-depth analysis of the diverse range of bacterial strains isolates from the devices. This study highlights the role of both well-known pathogens and less traditionally recognized species, such asBacillusspp., in these infections. By revealing that bacterial interactions analyzed here enhance biofilm formation, this research underscores the need to reconsider the clinical importance ofBacillusspp. in polymicrobial settings. This knowledge is critical for designing more effective therapeutic interventions to mitigate biofilm-related complications in medical devices.
Pharmacological characterisation of allosteric modulators at human mGlu5
Authors: Razzak Muhammad Abdur , Tran Kevin , McCague Roisin , Sengmany Kathy , Kos Jackson , Langiu Monica , Li Bohan , Hellyer Shane D , Gregory Karen J. 
Published: December 2024

AbstractThe metabotropic glutamate receptor 5 (mGlu5) is a Class C G protein-coupled receptor, ubiquitously expressed throughout the CNS. With major roles in cognition, learning and memory, mGlu5dysfunction is linked with numerous neurodegenerative and neuropsychiatric disorders, presenting a viable therapeutic target. Allosteric modulators bind topographically distinct sites from glutamate and other orthosteric agonists and enhance (positive allosteric modulators, PAMs), inhibit (negative allosteric modulators, NAMs) or do not effect (neutral allosteric ligands, NALs) mGlu5function. While mGlu5modulators have efficacy inin vivorodent models of CNS disorders, none have made it to the clinic. We hypothesise this lack of translatability is arises from preclinical optimisation using on non-human pharmacological data, as functional studies are predominantly performed using rat mGlu5and non-human brain neuronal cultures. Here we assess and quantify the impact of eleven chemically and pharmacologically diverse mGlu5PAMs, NAMs and NALs on human mGlu5activity using radioligand binding, iCa2+mobilisation and IP1accumulation assays. By comparing to published and newly generated data for rat mGlu5we show that while modulator pharmacology is relatively consistent across species, ligand dependent species differences in allosteric modulator affinity, cooperativity and probe dependence are evident. Additionally, we report PAM-dependent effects on orthosteric agonist kinetic profiles at human mGlu5.Together, these data highlight the importance of systematic evaluation of mGlu5allosteric ligand activity at human mGlu5to improve drug design and overcome potential barriers to translatability to clinical settings.
Workplace experiences as push and pull factors – How are perceived office conditions associated with teleworking preferences?
Authors: Haapakangas Annu , Hirvonen Suvi , Airaksinen Jaakko , Tulenheimo-Eklund Elina , Ruohomäki Virpi 
Published: December 2024

Purpose
The increase in teleworking has highlighted the role of office design in hybrid work. The purpose of this study is to examine employees’ workplace experiences as push and pull factors for working on-site. The study investigated which aspects of perceived office conditions are associated with employees’ preference to increase or decrease teleworking, taking into account other potential predictors of these preferences (i.e. demographic factors, psychosocial factors, employee well-being and work ability).

Design/methodology/approach
A cross-sectional survey was conducted in four Finnish workplaces in autumn 2022 (n = 923). The offices mostly represented a modern activity-based design. The authors analysed the data using multinomial regression, and adjusted for gender, age and education.

Findings
The workplace experiences were mainly a push factor as, for example, insufficient workspaces for quiet work and spontaneous collaboration and the amount of work and storage space were associated with preferences to increase telework. Only task privacy was both a push and pull factor: better privacy was associated with a preference to decrease telework, and vice versa. The current amount of telework was related to telework preferences, whereas psychosocial factors, employee well-being and work ability were not.

Practical implications
Ensuring satisfactory task privacy and providing adequate workspaces for work requiring concentration appear particularly important in making the office more attractive in hybrid work. Office design should be considered an integral component of organizational models of hybrid work.

Originality/value
The study bridges research on telework and office design. It provides novel evidence on the role of the office in post-pandemic workplaces.
Perspectives of Black female STEM majors: culturally responsive online teaching practices among higher education institutions
Authors: Terrell Shockley Ebony , Ellis Valeisha , Ivy Kelly K. 
Published: December 2024

Purpose
Culture is important and influential in how students learn STEM. This study aims to examine whether there is a pedagogical nexus between culturally successful teaching practices, i.e. culturally responsive teaching (CRT), online learning management systems (LMS) and STEM pedagogy among Black undergraduate women in STEM during the COVID-19 pandemic.

Design/methodology/approach
Using descriptive data from a quantitative survey exploring the four domains of the CRT framework: care, communication, curriculum and instruction, this study examines the teaching practices experienced via online learning of 26 Black female STEM majors regarding learning management systems and methods utilized.

Findings
The analytic framework utilized in this study was Gay’s (2000, 2002) framework for CRT. Using data from a purposive sample of Black female STEM majors, researchers examined if students experienced culturally responsive teaching practices during the COVID-19 pandemic. The research team also explored the LMS and the method(s) of instruction.

Originality/value
Because of the limited publications on the culturally successful learning experiences of Black STEM majors in online learning spaces, this work offers the use of CRT as an analytic frame to examine the use of CRT practices with Black female STEM majors.
Re-imagining education in Haiti through a lens of de-coloniality
Authors: Damas Rudolph 
Published: December 2024

Purpose
Scholars such as Hebblethwaite (2012) argue that societal elements like the pressure for students to learn French in Haiti are deeply rooted in colonial traditions which were originally intended to hinder long-term development and continue to do so within the country. The purpose of this paper is to widen the scope of Hebblethwaite’s discussion on language and question other social norms within educational institutions, which are having a negative impact on educational attainment. This purpose is accomplished by way of an empirical study of primary school education reform efforts in Haiti through a lens of de-coloniality as defined by Walter Mignolo (2005).

Design/methodology/approach
Given that this is an empirical study on education reform in Haiti, I have conducted this study solely through the analysis of literature and evidence from past work on education reform in Haiti and other countries with similar challenges. The body of the research is separated into two parts, and the first is a critical historical analysis of the context. The second is a comparative analysis of two different case studies on education reform projects that have occurred in Haiti. This will also be followed by a conclusive analysis of similar efforts in communities around the world.

Findings
This study demonstrates that primary school students, teachers and their communities in Haiti respond better to education development projects that place mother-tongue learning, grassroots community participation and culturally relevant pedagogy at the forefront of daily operational planning. These factors would play a key role in setting the foundation for students to be both productive Haitian citizens first and global citizens second. The literature reviewed also demonstrates that historically, education has focused far too heavily on models that work for or originate from the global north and not enough on building an education system tailored to Haiti.

Research limitations/implications
Since barriers such as societal norms need to be addressed through organic grassroots movements, which take time to be effective, reform from this perspective is better suited for the longer term than the shorter term. In the conclusion, this is considered to be a limitation when it comes to identifying short-term solutions to education, especially given that grassroots projects such as Buiga-Sunrise take time to establish winning practices that support self-sufficiency.

Originality/value
Literacy rates in Haiti for the year 2012 were around 48% for adults and 72% for youth (UNESCO Institute for Statistics, 2012). Not to mention that only 50% of children attend primary schools and 20% attend secondary schools (UNICEF Haiti, 2011, as cited in Jean-Marie and Sider, 2014). Such low educational attainment shows a need for greater access to education, and as much as the privatisation of schools is a significant barrier, as argued by Sider and Jean Marie, there are other impactful factors that remain to be addressed.
Destination online reviews: lexicons and thematic arguments on social responsibility
Authors: Bigne Enrique , Zanfardini Marina , Andreu Luisa 
Published: December 2024

Purpose
The purpose of this study is to examine online comments on destination social responsibility (DSR). Typically, visitors do not discuss their experiences in terms explicitly related to DSR. This study analyzes the natural language that visitors use and identifies connections to the dimensions of DSR (i.e. environmental, sociocultural and economic responsibility). The research objectives are to identify the lexicons of tourists and the thematic arguments related to DSR dimensions. This study also analyzes the association between those dimensions and tourist destination types.

Design/methodology/approach
This study reviewed 5,113 Tripadvisor comments about the top-ranking destinations in two countries. Expert judges used text mining techniques to explore lexicons and topics. Factor correspondence analysis was used to analyze the relationship between identified DSR thematic arguments and tourist destination types (e.g. nature, urban, culture and beach destinations).

Findings
Drawing from social identity theory and self-extension theoretical approaches, this study reveals that tourists share opinions using a lexicon of DSR dimensions. Interestingly, the results of this study identify five sub-dimensions in online reviews related to social responsibility in tourism destinations: environmental (i.e. “natural landscapes”), sociocultural (i.e. “cultural heritage” and “urban leisure and outdoor spaces”) and economic dimensions (i.e. “tourism services” and “guided tours and experiences”). This paper also describes associations between DSR lexicons, the reviews’ main sub-dimensions and destination types.

Research limitations/implications
The empirical study analyzes online reviews of top-ten tourism destinations in Spain and Argentina, countries with similar cultural backgrounds. Because of the focus on well-ranked destinations, this sample may exhibit a higher proportion of positive comments. However, the methodological contribution can extend to other destinations. This research can help researchers and destination managers understand the issues on which tourists comment in the context of their destination experiences and the three dimensions of DSR.

Originality/value
There is a lack of studies using natural language processing techniques to analyze the intersection between UGC and DSR; social media research has neglected this topic. This study integrates the five sub-dimensions the authors identified into a three-dimensional schema and enriches the classic DSR framework.
Partial sales of lumpy assets
Authors: Chiang Kevin C. H. , Connolly Robert A. , Liu Crocker H. 
Published: December 2024

AbstractUsing a new dataset, we study the pricing of a partial interest in a lumpy asset. Ex ante, it is unclear what a partial interest is worth due to countervailing factors which include asset quality, control benefits, asymmetrical information, and illiquidity. Contrary to the partial sale discount norm in IRS tax rules, court rulings, and appraisal methodology, we find that partial interests typically trade at a price premium. We identify salient factors that account for this premium. We find lower premiums exist for partnership buyouts compared to new outside buyers. No premium exists for a 50% co‐control stake.
The waiting game: Anticipatory stress and its proliferation during jail incarceration
Authors: Turney Kristin , Sugie Naomi F. , Marín Estéfani , Kaiser Daniela E. 
Published: December 2024

AbstractAnticipatory stress—or worries about the future that produce emotional distress—may explain some of the deleterious repercussions of incarceration for health. We use nearly 500 interviews with incarcerated men and their family members to describe anticipatory stress stemming from the stressor of jail incarceration, a commonly experienced but understudied type of confinement distinct from prison incarceration. We identify and explain how jail incarceration involves a powerful confluence of factors that give rise to anticipatory stress about adjudication, family relationships, the well‐being of loved ones, and reintegration. We describe three types of anticipatory stress proliferation between incarcerated men and their families. First, anticipatory stress commonly proliferates from incarcerated men to their children's mothers and their own mothers, with anticipatory stress being particularly salient when it involves the possibility of major changes, system irrationality, and powerlessness. Second, family members can experience anticipatory stress regardless of whether their incarcerated loved one reports anticipatory stress, shaped in part by men's extensive criminal legal contact. Third, family members with weak relationships with incarcerated men generally do not experience anticipatory stress despite the anticipatory stress endured by their incarcerated loved ones. This study provides a framework for understanding how other stages of criminal legal contact contribute to health inequalities among incarcerated people and their families.
The Arrival of Highly Pathogenic Avian Influenza Viruses in North America, Ensuing Epizootics in Poultry and Dairy Farms and Difficulties in Scientific Naming
Authors: Brüssow Harald 
Published: December 2024

ABSTRACTThe highly pathogenic avian influenza virus (HPAIV) H5N1, first isolated in 1996 in China, spread rapidly across Eurasia and caused major epizootics in wild and domesticated birds, as well as spillover infections in humans characterised by high mortality. Avian influenza viruses are therefore candidate viruses for a human pandemic. Surprisingly, HPAIV was not isolated in North America until 2014. With the help of intensive biological sampling and viral genome sequencing, the intrusion of HPAIV into North America could be retraced to two separate events. First, migratory birds carried HPAIV from East Siberia via Beringia and dispersed the virus along the Pacific flyway. After reassortment with genes of local low pathogenic avian influenza viruses, HPAIV H5 caused 2015 a major epizootic on poultry farms in the US Mid‐West. After costly containment, HPAIV dropped below the detection limit. In 2021, Eurasian HPAIV H5 viruses arrived a second time in North America, carried by migratory birds to Canada via the Atlantic flyway, using Iceland as a stop. The H5 virus then spread with water birds along the East Coast of the United States and dispersed across the United States. In contrast to the 2015 poultry outbreak, spillover infections into diverse species of mammals were now observed. The events culminated in the 2024 HPAIV H5 epizootic in dairy cows affecting 300 dairy herds in 14 US states. The cattle epizootic was spread mainly by milking machinery and animal transport. On affected farms infected cats developed fatal neurological diseases. Retail milk across the United States frequently contains viral RNA, but so far only a few milk farm workers have developed mild symptoms. The tracing of HPAIV with viral genome sequencing complicated the taxonomical naming of influenza viruses raising fundamental problems in how to mirror biological complexity in written plain language, rendering communication with the lay public difficult.