bluuebunny/crossref_metadata_2025_split huggingface dataset:
CircRNA ZNF609 functions as a competitive endogenous RNA to regulate FOXP4 expression by sponging miR‐138‐5p in renal carcinoma
Authors: Xiong Yunhe , Zhang Jiabin , Song Chao 
Published: November 2018

AbstractCircular RNA (circRNA) play important roles in the pathological processes of many diseases. By analyzing the results of the GSE100186 chip, we found that the expression of circRNA ZNF609 (circ‐ZNF609) was significantly increased in renal cell carcinoma. Recently, there are studies showing that circ‐ZNF609 can regulate cell proliferation and invasion ability of various cells. In this study, we investigated whether circ‐ZNF609 may affect cell invasion and proliferation in renal carcinoma. Quantitative reverse transcription polymerase chain reaction was performed to detect the expression of circ‐ZNF609 in renal carcinoma cell lines and renal epithelial cells. The direct interaction between microRNA‐138‐5p (miR‐138‐5p) and forkhead box P4 (FOXP4) or circ‐ZNF609 was confirmed by luciferase reporter assay and RNA immunoprecipitation assay. We use Cell Counting Kit‐8, 5‐ethynyl‐2′‐deoxyuridine, and Matrigel assays to assess the effect of miR‐138‐5p or circ‐ZNF609 on cell proliferation or invasion ability. And we found that circ‐ZNF609 is significantly increased in renal carcinoma cell lines. In addition, the high expression of circ‐ZNF609 promotes cell proliferation and invasion ability. In short, our current study reveals the role of the circ‐ZNF609/miR‐138‐5p/FOXP4 regulatory network in renal carcinoma and provides a new perspective for the pathogenesis of renal carcinoma.
A novel infram deletion in MSH6 gene in glioma: Conversation on MSH6 mutations in brain tumors
Authors: Deris Zayeri Zeinab , Tahmasebi Birgani Maryam , Mohammadi Asl Javad , Kashipazha Davood , Hajjari Mohammadreza 
Published: November 2018

AbstractObjective and backgroundHistological and molecular information and biopsy help in the diagnosis of the type and grade of tumors and increase the value of estimation of the biological behavior of tumors. In this study, we focused on a consanguineous Iranian Family with high prevalence of brain tumors in their pedigree and reviewed the literature on MSH6 mutations in brain tumors and the treatment responses focused on Gliomas.MethodWe chose a family with a high prevalence of brain tumor in their pedigree. We studied the proband's neuroimaging and brain proton magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), biopsy result, and whole‐genome sequencing.ResultThe neuroimaging and brain proton MRS reported a lesion in the right frontoparietal. The MRI revealed a large enhancible heterogenous mass in the right temporo‐fronto‐parieto‐occipital lobes with involvement of corpus callosum which was suggestive of glioma. The patient revealed a homozygous pattern for a novel 9 base‐pare deletion at the 912–914 codon on exon 4 of the MSH6 gene.DiscussionWe discuss several studies on MSH6 mutations in brain tumors and we discuss treatment responses in MSH6 mutations and the studies conducted to sensitize chemotherapy and radiotherapy resistance brain tumors to face this subject efficiently.ConclusionPatients should be evaluated for MMR mutation before chemo and radiotherapy, and it is valuable to follow‐up these mutations during the treatment too. In temozolomide (TMZ)‐resitance cases, it is suggested to use complementary strategies such as using HDACis and a combination of a STAT3 Inhibitor and an mTOR inhibitor, BER inhibition mechanism, and PARP‐1 inhibitor.
The role of nitric oxide signaling in renoprotective effects of hydrogen sulfide against chronic kidney disease in rats: Involvement of oxidative stress, autophagy and apoptosis
Authors: Shirazi Mohammad Khabbaz , Azarnezhad Asaad , Abazari Mohammad Foad , Poorebrahim Mansour , Ghoraeian Pegah , Sanadgol Nima , Bokharaie Hanieh , Heydari Sahar , Abbasi Amin , Kabiri Sahra , Aleagha Maryam Nouri , Enderami Seyed Ehsan , Dashtaki Amir Savar , Askari Hassan 
Published: November 2018

AbstractThe interplay between H2S and nitric oxide (NO) is thought to contribute to renal functions. The current study was designed to assess the role of NO in mediating the renoprotective effects of hydrogen sulfide in the 5/6 nephrectomy (5/6 Nx) animal model. Forty rats were randomly assigned to 5 experimental groups: (a) Sham; (b) 5/6 Nx; (c) 5/6Nx+sodium hydrosulfide‐a donor of H
2S, (5/6Nx+sodium hydrosulfide [NaHS]); (d) 5/6Nx+NaHS+
L‐NAME (a nonspecific nitric oxide synthase [NOS] inhibitor); (e) 5/6Nx+NaHS+aminoguanidine (a selective inhibitor of inducible NOS [iNOS]). Twelve weeks after 5/6 Nx, we assessed the expressions of iNOS and endothelial NOS (eNOS), oxidative/antioxidant status, renal fibrosis, urine N‐acetyl‐b‐glucosaminidase (NAG) activity as the markers of kidney injury and various markers of apoptosis, inflammation, remodeling, and autophagy. NaHS treatment protected the animals against chronic kidney injury as depicted by improved oxidative/antioxidant status, reduced apoptosis, and autophagy and attenuated messenger RNA (mRNA) expression of genes associated with inflammation, remodeling, and NAG activity. Eight weeks Nω‐nitro‐l‐arginine methyl ester (
L‐NAME) administration reduced the protective effects of hydrogen sulfide. In contrast, aminoguanidine augmented the beneficial effects of hydrogen sulfide. Our finding revealed some fascinating interactions between NO and H
2S in the kidney. Moreover, the study suggests that NO, in an isoform‐dependent manner, can exert renoprotective effects in 5/6 Nx model of CKD.
PCNA and JNK1‐Stat3 pathways respectively promotes and inhibits diabetes‐associated centrosome amplification by targeting at the ROCK1/14‐3‐3σ complex in human colon cancer HCT116 cells
Authors: Lu Yu Cheng , Wang Pu , Wang Jie , Ma Ronald , Lee Shao Chin 
Published: November 2018

AbstractWe have recently reported that type 2 diabetes promotes centrosome amplification via enhancing the expression, biding, and centrosome translocation of rho‐associated coiled‐coil containing protein kinase 1 (ROCK1)/14‐3‐3σ complex in HCT116 cells. In the functional proteomic study, we further investigated the molecular pathways underlying the centrosome amplification using HCT116 cells. We found that treatment of HCT116 cells with high glucose, insulin, and palmitic acid triggered the centrosome amplification and increased the expressions of proliferating cell nuclear antigen (PCNA), nucleophosmin (NPM), and 14‐3‐3σ. Individual knockdown of PCNA, NPM, or 14‐3‐3σ inhibited the centrosome amplification. Knockdown of PCNA inhibited the treatment‐increased expression of ROCK1, whereas knockdown of ROCK1 did not affect the PCNA expression. High glucose, insulin, and palmitic acid also increased the expressions of c‐Jun N‐terminal kinase‐1 (JNK1) and signal transducer and activator of transcription 3 (Stat3), individual knockdown of which upregulated the treatment‐increased expression of 14‐3‐3σ and promoted the centrosome amplification. In contrast, overexpression of JNK1 inhibited the centrosome amplification. Knockdown of Stat3 enhanced the centrosome translocation of 14‐3‐3σ. Moreover, we showed that knockdown of JNK1 inhibited the treatment‐increased expression of Stat3. Knockdown of PCNA, JNK1, or Stat3 did not have an effect on NPM and vice versa. In conclusion, our results suggest that PCNA and JNK1‐Stat3 pathways respectively promotes and feedback inhibits the centrosome amplification by targeting at the ROCK1/14‐3‐3σ complex, and NPM serves as an independent signal for the centrosome amplification.
A note on a Brooks' type theorem for DP‐coloring
Authors: Kim Seog‐Jin , Ozeki Kenta 
Published: November 2018

AbstractDvořák and Postle introduced DP‐coloring of simple graphs as a generalization of list‐coloring. They proved a Brooks' type theorem for DP‐coloring; and Bernshteyn, Kostochka, and Pron extended it to DP‐coloring of multigraphs. However, detailed structure, when a multigraph does not admit DP‐coloring, was not specified. In this note, we make this point clear and give the complete structure. This is also motivated by the relation to signed coloring of signed graphs.
On dihedral flows in embedded graphs
Authors: Litjens Bart 
Published: November 2018

AbstractLet be a multigraph with for each vertex a cyclic order of the edges incident with it. For , let be the dihedral group of order . Define . Goodall et al in 2016 asked whether admits a nowhere‐identity ‐flow if and only if it admits a nowhere‐identity ‐flow with (a “nowhere‐identity dihedral ‐flow”). We give counterexamples to this statement and provide general obstructions. Furthermore, the complexity of deciding the existence of nowhere‐identity ‐flows is discussed. Lastly, graphs in which the equivalence of the existence of flows as above is true are described. We focus particularly on cubic graphs.
Comparative Study of Pattern‐Based Versus Size Ratio Ultrasound Strain Elastographic Techniques on Breast Masses
Authors: Leong Lester Chee Hao , Moey Tammy Hui Lin , Tan Puay Hoon , Fook‐Chong Stephanie , Sim Llewellyn Shao‐jen 
Published: November 2018

ObjectivesThe aim of this study was to compare the diagnostic performance of strain elastographic techniques involving pattern‐based elastography versus size ratio elastography on breast masses.MethodsFemale patients presenting to the radiology department for ultrasound (US)‐guided biopsies, fine‐needle aspirations, or localizations of breast masses were invited to undergo US elastographic assessments of the lesions before the breast procedures. The masses were evaluated for color score and color map size ratio elastographic assessments with one US machine and size ratio and grayscale strain pattern elastographic assessments with another machine. With the histopathologic diagnosis as the reference standard, the sensitivity, specificity, and area under the receiver operating characteristic curve were compared among the 4 groups.ResultsA total of 154 breast masses from 139 women were assessed. The sensitivity and specificity were 0.615 (95% confidence interval, 0.470–0.747) and 0.824 (0.736–0.892), respectively for the color score, 0.962 (0.868–0.995) and 0.765 (0.670–0.843) for the size ratio, 0.904 (0.790–0.968) and 0.745 (0.649–0.826) for the color map size ratio, and 0.635 (0.490–0.764) and 0.422 (0.324–0.523) for the grayscale strain pattern. The areas under the receiver operating characteristic curve were 0.729 for the color score, 0.874 for the size ratio (P = .001 with the color score as a reference), 0.836 for the color map size ratio (P = .002), and 0.556 for the grayscale strain pattern (P < .001).ConclusionsSize ratio elastography had higher sensitivity and better diagnostic accuracy compared to color score elastography. This superiority was demonstrated on two different US systems, and size ratio elastography should thus be considered over color score elastography in the adjunctive US assessment of breast lesions.
Vocal motor control and central auditory impairments in unilateral vocal fold paralysis
Authors: Naunheim Molly L. , Yung Katherine C. , Schneider Sarah L. , Henderson‐Sabes Jennifer , Kothare Hardik , Mizuiri Danielle , Klein David J. , Houde John F. , Nagarajan Srikantan S. , Cheung Steven W. 
Published: November 2018

ObjectivesTo evaluate differences in vocal motor control and central auditory processing between treated unilateral vocal fold paralysis (UVFP) and healthy control cohorts.Study DesignCross‐sectional.MethodsTen UVFP study patients treated by type I thyroplasty with stable voices were compared to 12 control subjects for vocal motor control using a pitch perturbation response task and central auditory processing performance using a battery of complex sound intelligibility assays that included adverse temporal and noise conditions. Standard clinical evaluations of voice production and peripheral audiometric sensitivity were performed.ResultsVocal motor control was impaired in treated UVFP. The UVFP cohort exhibited a 32.5% reduction in the instantaneous, subconscious compensatory response to pitch feedback perturbation in the interval between 150 ms and 550 ms following onset (P < 0.0001, linear mixed effects model). This impairment cannot simply be ascribed to vocal motor capacity insufficiency in the UVFP cohort because both cohorts demonstrated comparable functional capacity to perform the vocal motor task. The UVFP cohort also showed greater propensity for central auditory processing impairment (P < 0.05), notably for temporal compression and added noise challenges.ConclusionCombined central vocal motor control and auditory processing impairments in treated UVFP highlight reciprocal interdependency of sensory and motor systems. This pilot study suggests that peripheral motor impairment of the larynx can degrade central auditory processing, which in turn may contribute to vocal motor control impairment. A more complete restoration communicative function in UVFP will require deeper understanding of sensory, motor, and sensorimotor aspects of the human communication loop.Level of Evidence3bLaryngoscope, 129:2112–2117, 2019
Postoperative care in an intermediate‐level medical unit after head and neck microvascular free flap reconstruction
Authors: Yu Phoebe K. , Sethi Rosh K.V. , Rathi Vinay , Puram Sidharth V. , Lin Derrick T. , Emerick Kevin S. , Durand Marlene L. , Deschler Daniel G. 
Published: November 2018

ObjectiveThe need for intensive care unit (ICU) admission and mechanical ventilation after head and neck microvascular free flap reconstructive surgery remains controversial. Our institution has maintained a longstanding practice of immediately taking patients off mechanical ventilation with subsequent transfer to intermediate, non‐ICU level of care with specialized otolaryngologic nursing. Our objective was to describe postoperative outcomes for a large cohort of patients undergoing this protocol and to examine the need for routine ICU transfer.Materials and MethodsWe performed a retrospective review of 512 consecutive free flaps treated with a standard protocol of immediate postoperative transfer to an intermediate‐level care unit with specialized otolaryngology nursing. Outcome measures included ICU transfer, ventilator requirement, flap failure, postoperative complications, and length of stay. Predictors of ICU transfer were identified by multivariable logistic regression.ResultsThe vast majority of patients did not require intensive care. Only a small fraction (n = 18 patients, 3.5%) subsequently transferred to the ICU, most commonly for respiratory distress, cardiac events, and infection. The most common complications were delirium/agitation (n = 55; 10.7%) and pneumonia (n = 51; 10.0%). Sixty‐five cases (12.7%) returned to the OR, most commonly for hematoma/bleeding (n = 41; 8.0%) and anastomosis revision (n = 20; 3.9%). Heavy alcohol consumption and greater number of medical comorbidities were significant predictors of subsequent ICU transfer.ConclusionsAmong head and neck free flap patients, routine cessation of mechanical ventilation and transfer to intermediate‐level care with specialized ENT nursing was found to be safe with infrequent subsequent ICU transfer and low complication rates. Routine transfer to intermediate‐level care in this population may prevent unnecessary ICU utilization and facilitate the delivery of high‐value, disease‐centered care.Level of Evidence3b
Solutions with sign information for nonlinear nonhomogeneous problems
Authors: S. Papageorgiou Nikolaos , Winkert Patrick 
Published: November 2018

AbstractWe consider a parametric elliptic equation driven by a nonlinear nonhomogeneous differential operator and with a Robin boundary condition. In the first part we prove the existence of positive solutions and state a bifurcation‐type result describing how the set of positive solutions changes as the parameter varies. In the second part we show that problem admits nodal (sign‐changing) solutions provided the parameter is sufficiently large.
Eye movement disorders and neurological symptoms in late‐onset inborn errors of metabolism
Authors: Koens Lisette H. , Tijssen Marina A.J. , Lange Fiete , Wolffenbuttel Bruce H.R. , Rufa Alessandra , Zee David S. , de Koning Tom J. 
Published: November 2018

ABSTRACTInborn errors of metabolism in adults are still largely unexplored. Despite the fact that adult‐onset phenotypes have been known for many years, little attention is given to these disorders in neurological practice. The adult‐onset presentation differs from childhood‐onset phenotypes, often leading to considerable diagnostic delay. The identification of these patients at the earliest stage of disease is important, given that early treatment may prevent or lessen further brain damage. Neurological and psychiatric symptoms occur more frequently in adult forms. Abnormalities of eye movements are also common and can be the presenting sign. Eye movement disorders can be classified as central or peripheral. Central forms are frequently observed in lysosomal storage disorders, whereas peripheral forms are a key feature of mitochondrial disease. Furthermore, oculogyric crisis is an important feature in disorders affecting dopamine syntheses or transport. Ocular motor disorders are often not reported by the patient, and abnormalities can be easily overlooked in a general examination. In adults with unexplained psychiatric and neurological symptoms, a special focus on examination of eye movements can serve as a relatively simple clinical tool to detect a metabolic disorder. Eye movements can be easily quantified and analyzed with video‐oculography, making them a valuable biomarker for following the natural course of disease or the response to therapies. Here, we review, for the first time, eye movement disorders that can occur in inborn errors of metabolism, with a focus on late‐onset forms. We provide a step‐by‐step overview that will help clinicians to examine and interpret eye movement disorders. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Serum soluble lymphocyte activation gene‐3 as a diagnostic biomarker in Parkinson's disease: A pilot multicenter study
Authors: Cui Shi‐shuang , Du Juan‐Juan , Liu Shi‐Hua , Meng Jie , Lin Yi‐Qi , Li Gen , He Yi‐Xi , Zhang Ping‐Chen , Chen Shengdi , Wang Gang 
Published: November 2018

AbstractObjectiveLymphocyte activation gene‐3 (LAG‐3) could mediate pathological α‐synuclein transmission in neurodegeneration and may be involved in the pathogenesis of Parkinson's disease (PD). The aim of the present study was to explore soluble LAG‐3 (sLAG‐3) as a potential diagnostic biomarker for PD.MethodsSerum sLAG‐3 concentrations were measured by a quantitative ELISA for patients with PD, essential tremor (ET) and age‐ and sex‐matched controls. The relationships between sLAG‐3 and clinical phenotype were assessed via correlation analysis and logistic regression.ResultsSerum sLAG‐3 levels in patients with PD were significantly higher than those in ET patients and age‐ and sex‐matched controls. The area under the curve of serum sLAG‐3 in differentiating PD from age‐ and sex‐matched controls was 0.82. Serum sLAG‐3 was associated with non‐motor symptoms and excessive daytime sleep.ConclusionsLAG‐3 is a candidate novel biomarker for PD. © 2018 International Parkinson and Movement Disorder Society
Single‐/dual‐band triple‐mode cavity filters with wide tunable frequency range
Authors: Wong Sai‐Wai , Deng Fei , Li Eric S. 
Published: November 2018

AbstractTwo third‐order continuously tunable bandpass filters featuring single‐/dual‐band operations, respectively, are presented in this letter. One requires a set of three metallic posts in a single metallic cavity, while the other needs one more set to achieve the desired dual‐band operation. The length of each post is adjusted through a screw from its top to establish the center frequency of the passband. Moreover, the coupling among these three resonators can be controlled by varying their locations to determine the bandwidth of the passband. At the bottom of the cavity, grooves are created to linearize and extend the frequency tuning range. In addition, compared to traditional coaxial cavity filters, the proposed designs offer the advantages of ease in fabrication and low in weight. A practical example for the dual‐band design is presented for experimental verification. The simulated range for the tunable passband is from 0.8 to 3.2 GHz, which amounts to a fractional bandwidth of 120%. The simulated results agree well with the measured data.
Phosphate‐Loaded Hydrogel Nanoparticles for Sepsis Prevention Prepared via Inverse Miniemulsion Polymerization
Authors: Vadlamudi Srivishnu , Nichols Dylan , Papavasiliou Georgia , Teymour Fouad 
Published: November 2018

AbstractLocal depletion of intestinal phosphate triggers changes in bacterial phenotypes that adversely affect the health of the host. This article describes a process for encapsulating phosphates in crosslinked poly(ethylene glycol) diacrylate (PEGDA) nanoparticles using inverse miniemulsion polymerization as a drug delivery approach for sustained release of phosphates to the intestinal epithelium. The effects of crosslinker, PEGDA co‐monomer, N‐vinyl pyrrolidone, (NVP) and surfactant concentrations on the nanoparticle size distribution, swelling ratio and monomer conversion are investigated. Increased surfactant and PEGDA concentrations result in smaller particle size and swelling ratio. A copolymerization model of crosslinking is used to predict conversion and gelation dynamics as a function of polymerization conditions. The model assumes that bulk polymerization can be used to approximate inverse miniemulsion polymerization with an aqueous‐phase initiator. The initiator efficiency is used as an adjustable parameter to simulate the conversion dynamics, thus accounting for radical confinement effects and interaction with emulsifier molecules.
Investigation of electrochemical properties and gas adsorption studies of novel sandwich core phthalocyanines
Authors: Şenocak Ahmet , Köksoy Baybars , Demirbaş Erhan , Durmuş Mahmut 
Published: November 2018

AbstractIn this study, bis(tetra‐iodo‐phthalocyanine)s containing different lanthanide (III) metals, namely, samarium (III) (SmPc2), europium (III) (EuPc2), gadolinium (III) (GdPc2), dysprosium (III) (DyPc2), and terbium (III) (TbPc2) were synthesized for the first time, and their structural characterizations were determined by elemental analyses and different spectroscopic methods such as Ultraviolet–Visible (UV‐Vis), Fourier transform infrared (FT‐IR), and matrix‐assisted laser desorption/ionization‐time of flight (MALDI‐TOF). Moreover, voltammetric, in situ spectroelectrochemical, chemical redox, and quartz crystal microbalance (QCM) gas adsorption properties of the synthesized compounds were evaluated. The distinct spectral and color changes during the redox reactions for the complexes indicated a potential use in electrochromic materials. In addition, ammonia gas adsorption properties of the complexes were found to be relevant to central metal atom size, and the value for the ammonia gas adsorption at 15 μg/L was the highest for SmPc2 (20 ng), and the lowest was DyPc2 (1.4 ng).