bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uso do ambiente Code.org para ensino de programação no Ensino Fundamental I - uma experiência no Desafio Hora do Código.
Authors: Kaminski Márcia Regina , Boscarioli Clodis 
Published: April 2019

<p class="ResumoRevista"><strong>Resumo: </strong>O ensino de programação pode oferecer importantes contribuições ao desenvolvimento dos estudantes. Vários movimentos incentivam o ensino de programação nas escolas por meio de eventos como os da Hora do Código. A plataforma Code.org é um ambiente utilizado para promoção destes eventos que disponibiliza gratuitamente jogos educacionais para o ensino de programação. Este trabalho relata a experiência da participação de alunos de 2º a 5º ano de Ensino Fundamental I de uma escola pública em um destes eventos ocorrido no Estado do XXXXXX. Os resultados positivos motivaram a escola a estender as atividades com a plataforma Code.org para alunos de 1º ano e Educação Infantil. Os resultados dessas experiências são também detalhados.</p><p><strong>Abstract:</strong> The teaching of programming is gaining space in the school environment given the contributions it can offer to student development. Several movements encourage this work in schools through events such as Hora do Código. The Code.org platform is an environment used to promote these events that provides free educational games for programming learning. This paper reports the experience of the participation of students from 2nd to 5th year of Elementary School I of a public school in one of these events occurred in the State of XXXX. The positive results motivated the school to extend its activities with the Code.org platform for 1st year students and Early Childhood Education. The results of these experiments are also detailed.</p><p> </p>
Dual labeling with 5-aminolevulinic acid and fluorescein in high-grade glioma surgery with a prototype filter system built into a neurosurgical microscope: technical note
Authors: Suero Molina Eric , Ewelt Christian , Warneke Nils , Schwake Michael , Müther Michael , Schipmann Stephanie , Stummer Walter 
Published: April 2019

OBJECTIVERecent efforts to improve visualization of 5-aminolevulinic acid (5-ALA)–induced protoporphyrin IX (PPIX) fluorescence resulted in a dual-labeling technique, combining it with fluorescein sodium in a prototype setup. Fluorescein identifies regions with blood-brain barrier breakdown in gliomas. However, normally perfused and edematous brain fluoresces unselectively, with strong background enhancement. The aim of this study was to test the feasibility of a novel, integrated filter combination using porphyrins for selective tumor identification and fluorescein for background enhancement.METHODSA microscope with a novel built-in filter system (YB 475) for visualizing both fluorescein and 5-ALA–induced porphyrins was used. Resection limits were identified with the conventional BLUE 400 filter system. Six patients harboring contrast ring-enhancing lesions were analyzed.RESULTSThe complete surgical field could now be illuminated. Fluorescein was helpful for improving background visualization, and enhancing dura, edematous tissue, and cortex. Overlapping regions with both fluorophores harbored merged orange fluorescence. PPIX fluorescence was better visualized, even in areas beyond a normal working distance of approximately 25 cm, where the BLUE 400 filters recognized no or weak fluorescence.CONCLUSIONSThe novel filter system improved general tissue brightness and background visualization, enhancing fluorescence-guided tumor resection. Furthermore, it appears promising from a scientific perspective, enabling the simultaneous and direct observation of areas with blood-brain barrier breakdown and PPIX fluorescence.
Outcome analysis of surgery for symptomatic spinal metastases in long-term cancer survivors
Authors: Barzilai Ori , McLaughlin Lily , Lis Eric , Yamada Yoshiya , Bilsky Mark H. , Laufer Ilya 
Published: April 2019

OBJECTIVEAs patients with metastatic cancer live longer, an increased emphasis is placed on long-term therapeutic outcomes. The current study evaluates outcomes of long-term cancer survivors following surgery for spinal metastases.METHODSThe study population included patients surgically treated at a tertiary cancer center between January 2010 and December 2015 who survived at least 24 months postoperatively. A retrospective chart and imaging review was performed to collect data regarding patient demographics; tumor histology; type and extent of spinal intervention; radiation data, including treatment dose and field; long-term sequelae, including local tumor control; and reoperations, repeat irradiation, or postoperative kyphoplasty at a previously treated level.RESULTSEighty-eight patients were identified, of whom 44 were male, with a mean age of 61 years. The mean clinical follow-up for the cohort was 44.6 months (range 24.2–88.3 months). Open posterolateral decompression and stabilization was performed in 67 patients and percutaneous minimally invasive surgery in 21. In the total cohort, 84% received postoperative adjuvant radiation and 27% were operated on for progression following radiation. Posttreatment local tumor progression was identified in 10 patients (11%) at the index treatment level and 5 additional patients had a marginal failure; all of these patients were treated with repeat irradiation with 5 patients requiring a reoperation. In total, at least 1 additional surgical intervention was performed at the index level in 20 (23%) of the 88 patients: 11 for hardware failure, 5 for progression of disease, 3 for wound complications, and 1 for postoperative hematoma. Most reoperations (85%) were delayed at more than 3 months from the index surgery. Wound infections or dehiscence requiring additional surgical intervention occurred in 3 patients, all of which occurred more than a year postoperatively. Kyphoplasty at a previously operated level was performed in 3 cases due to progressive fractures.CONCLUSIONSDurable tumor control can be achieved in long-term cancer survivors surgically treated for symptomatic spinal metastases with limited complications. Complications observed after long-term follow-up include local tumor recurrence/progression, marginal tumor control failures, early or late hardware complications, late wound complications, and progressive spinal instability or deformity.
Outcome of unilateral versus standard open midline approach for bilateral decompression in lumbar spinal stenosis: is “over the top” really better? A Swiss prospective multicenter cohort study
Authors: Ulrich Nils H. , Burgstaller Jakob M. , Gravestock Isaac , Pichierri Giuseppe , Wertli Maria M. , Steurer Johann , Farshad Mazda , Porchet François 
Published: April 2019

OBJECTIVEIn this retrospective analysis of a prospective multicenter cohort study, the authors assessed which surgical approach, 1) the unilateral laminotomy with bilateral spinal canal decompression (ULBD; also called “over the top”) or 2) the standard open bilateral decompression (SOBD), achieves better clinical outcomes in the long-term follow-up. The optimal surgical approach (ULBD vs SOBD) to treat lumbar spinal stenosis remains controversial.METHODSThe main outcomes of this study were changes in a spinal stenosis measure (SSM) symptoms score, SSM function score, and quality of life (sum score of the 3-level version of the EQ-5D tool [EQ-5D-3L]) over time. These outcome parameters were measured at baseline and at 12-, 24-, and 36-month follow-ups. To obtain an unbiased result on the effect of ULBD compared to SOBD the authors used matching techniques relying on propensity scores. The latter were calculated based on a logistic regression model including relevant confounders. Additional outcomes of interest were raw changes in main outcomes and in the Roland and Morris Disability Questionnaire from baseline to 12, 24, and 36 months.RESULTSFor this study, 277 patients met the inclusion criteria. One hundred forty-nine patients were treated by ULBD, and 128 were treated by SOBD. After propensity score matching, 128 patients were left in each group. In the matched cohort, the mean (95% CI) estimated differences between ULBD and SOBD for change in SSM symptoms score from baseline to 12 months were −0.04 (−0.25 to 0.17), to 24 months −0.07 (−0.29 to 0.15), and to 36 months −0.04 (−0.28 to 0.21). For change in SSM function score, the estimated differences from baseline to 12 months were 0.06 (−0.08 to 0.21), to 24 months 0.08 (−0.07 to 0.22), and to 36 months 0.01 (−0.16 to 0.17). Differences in changes between groups in EQ-5D-3L sum scores were estimated to be −0.32 (−4.04 to 3.40), −0.89 (−4.76 to 2.98), and −2.71 (−7.16 to 1.74) from baseline to 12, 24, and 36 months, respectively. None of the group differences between ULBD and SOBD were statistically significant.CONCLUSIONSBoth surgical techniques, ULBD and SOBD, may provide effective treatment options for DLSS patients. The authors further determined that the patient outcome results for the technically more challenging ULBD seem not to be superior to those for the SOBD even after 3 years of follow-up.
Determination of dynamic instability in lumbar spondylolisthesis using flexion and extension standing radiographs versus neutral standing radiograph and supine MRI
Authors: Chan Vivien , Marro Alessandro , Rempel Jeremy , Nataraj Andrew 
Published: April 2019

OBJECTIVEIn this study the authors sought to compare the proportion of patients with lumbar spondylolisthesis detected to have dynamic instability based on flexion and extension standing radiographs versus neutral standing radiograph and supine MRI.METHODSThis was a single-center retrospective study of all consecutive adult patients diagnosed with spondylolisthesis from January 1, 2013, to July 31, 2018, for whom the required imaging was available for analysis. Two independent observers measured the amount of translation, in millimeters, on supine MRI and flexion, extension, and neutral standing radiographs using the Meyerding technique. Interobserver and intraobserver correlation coefficients were calculated. The difference in amount of translation was compared between 1) flexion and extension standing radiographs and 2) neutral standing radiograph and supine MRI. The proportion of patients with dynamic instability, defined as a ≥ 3 mm difference in the amount of translation measured on different imaging modalities, was reported. Correlation between amount of dynamic instability and change in back pain and leg pain 1 year after decompression and instrumented fusion was analyzed using multivariate regression analysis.RESULTSFifty-six patients were included in this study. The mean patient age was 57.1 years, and 55.4% of patients were female. The most commonly affected levels were L4–5 (60.7%) and L5–S1 (30.4%). The average translations measured on flexion standing radiograph, extension standing radiograph, neutral standing radiograph, and supine MRI were 12.5 mm, 11.9 mm, 10.1 mm, and 7.2 mm, respectively. The average difference between flexion and extension standing radiographs was 0.58 mm, with dynamic instability detected in 21.4% of patients. The average difference between neutral standing radiograph and supine MRI was 3.77 mm, with dynamic instability detected in 60.7% of patients. The intraobserver correlation coefficient ranged from 0.77 to 0.90 mm. The interobserver correlation coefficient ranged from 0.79 to 0.86 mm. In 44 patients who underwent decompression and instrumented fusion, the amount of dynamic instability between standing and supine imaging was significantly correlated with change in back pain (p < 0.001) and leg pain (p = 0.05) at the 12-month postoperative follow-up. There was no correlation between amount of dynamic instability between flexion and extension standing radiographs and postoperative back pain and leg pain.CONCLUSIONSMore patients were found to have dynamic instability by using neutral standing radiograph and supine MRI. In patients who received decompression and instrumented fusion, there was a significant correlation between dynamic instability on neutral standing radiograph and supine MRI and change in back pain and leg pain at 12 months.
CONSISTENT PATTERNS OF POSTMORTAL STRUCTURAL AND BIOCHEMICAL CHANGES IN DIAPHRAGM MUSCULAR TISSUE: IMPORTANCE FOR FORENSIC MEDICAL ESTIMATION OF TIME OF DEATH COMING
Authors: Konoval N.S. 
Published: April 2019

The issue on estimating the time of death coming still remains a challenge that requires a lot of questions to be answered, therefore, the development of new scientific methods aimed at overcoming these difficulties is a top priority in solving the problem of estimating the time of death coming.
The purpose of this study was to investigate the structural and biochemical changes in the muscle tissue of the diaphragm in the early post-mortem period.
The muscular tissue samples of the diaphragm just below the lungs taken from 30 human corpses in the early post-mortem period (in time intervals of 3-13 hours from the onset of death) were investigated. We studied structural and biochemical markers in the homogenates of the muscles of the diaphragm: the content of glycogen, acid phosphatase, lactate, lactate dehydrogenase, lipofuscin, and cholinesterase. It was found out that in the early post-mortem period structural and biochemical changes in the muscle tissue of the diaphragm are characterized by regular morphological biochemical and biophysical changes. In particular, the post-mortem dynamic changes in glycogen, acid phosphatase and lipofuscin levels is most significant; i.e. within the time interval of 3–9 hours from the time of death coming, the assessment of the “cholinesterase / glycogen or acidic phosphatase / glycogen” ratio is the most diagnostically valuable, then after 9 hours the only “cholinesterase / glycogen” ratio is meaningful.
The content of glycogen in the homogenates of the diaphragm muscle tissue depending on the time of death coming ranged from (4.765 ± 0.058) mg / g in 3 hours, to (1.883 ± 0.027) mg / g in 13 hours after the death coming, reliably ( p <0.001) differing in time intervals. The inverse pattern was characterized by the acid phosphatase content: (2.748 ± 0.019) u / g in 3 hours and (4.49 ± 0.032) u / g in 13 hours. These markers are the most significant to demonstrate the patterns and can be used as critically important signs in forensic diagnosis.
Technological drivers of development of the market of tourist services
Authors: Shpyrnya O. V. 
Published: April 2019

This article analyzes the main technological drivers of changes in the market of tourist services that have occurred recently. The basic trends in the development of the tourist market have been studied. It is concluded that today the majority of tourists use the resources of the Internet when organizing travel. The basic trends in the development of the tourist services market over the past few years were reviewed, highlighting the main aspects. The tendency of diversification of the tourist business and expansion of the product offer due to direct online distribution has been noted.The main driver of the development of the tourist market was the change in consumer behavior of tourists and their “movement” into the Internet space. An important trend is the increasing interest of tour operators to the B2C segment with the simultaneous offer of services for direct online distribution on corporate sites. It was revealed the active development of aggregators (consolidators) of tourist services in the market, a high level of capitalization of digital companies in the field of tourism.The technological drivers in the market of tourist services included the activities of search engines, first of all, Yandex and Google, as well as the development of start-ups offering special, highly specialized services for tourists.
Interdisciplinary approach in research and teaching: advantages and problems of application
Authors: Kreps T V. 
Published: April 2019

The article deals with the interdisciplinary approach as an interdependent system of knowledge integration, expressed in research and teaching.The interpretation of the term “interdisciplinary approach in research and training” by E.M. Mirsky is taken as a basis, he interdisciplinary interaction is considered as a relationship between the systems of disciplinary knowledge in the process of integration and differentiation of sciences and collective forms of work of scientists in different fields of knowledge in the study of the same object.The article is based on an interdisciplinary approach the scientific base and system of education as a complex of fundamental and taxonomic disciplines are considered. The interdisciplinary connections with the focus on the effectiveness of training are considered. It contains the consistency of educational programs, determined by didactic goals and content. Interdisciplinary connections with the competence approach allow transferring knowledge, skills and abilities from one sphere of science and professional activity to another. Interdisciplinary approach is aimed at linking academic disciplines.There are several formats of implementation of an interdisciplinary approach to teaching at universities in the specialty “Economics”, based on an interdisciplinary approach offers to form the competence in the study of economic disciplines.The contradictions in the assimilation of knowledge, ideas and researching methods between the Sciences are smoothed out, and there is a complex application of the theory and practice obtained on the basis of the study of disciplines in professional activities. Both significant advantages and problems arising from the use of an interdisciplinary approach are noted.
Homo creators: deconstruction of the diverging way of thinking
Authors: Chumicheva N. V. 
Published: April 2019

The problem with generating advertising ideas, metaphors, narrative strands for video commercials, podcasts, and nontrivial script languages are on the copywriter’s agenda almost every day. The mass-produced creative approach is quite difficult, as far as “the Muse is mute” being an unachievable goal. The proposed article attempts to analyze the stages of creative impulse from the point of view of the psychological structure of associative thinking intuitive notion impulsive insights, and its correlation with the structure of consciousness.The article analyzes the convergent, and divergent pathways of the neural ensembles of the brain at all modeled spontaneous, or planned stages of the Muse’s first indications (‘AHA! ‘moment or sudden creative insight). The structure of non-trivial advertising images and original ideas in catching psycho-triggers; principles of brain’s working performance in an inspired moment; the whole creative process in challenging situations – the author tries to answer these and other question, to draw some conclusions against the present neuropsychological background.
Promotion features of enterprises of accomodation located in the online booking systems as a way of increasing the sales of the room fund
Authors: Polzikova E. V. 
Published: April 2019

The article describes the features of accommodation enterprises promotion in online booking systems, as the dynamic development of the activities of accommodation enterprises is due to the technical capabilities provided by technological progress. More efficient operation, improving the reliability of the information that is provided to the client, as well as the processing of a larger number of applications for reservations is due to automation.There is a change in the tourism business due to the development of the Internet, but in turn, not all tourist enterprises have time to join the new technologies. Despite the lack of analysis and doubts of many specialists in e-Commerce, the accommodation enterprises are increasingly involved in the electronic world. Accommodation enterprises that have their own websites and use online booking systems receive new highly effective marketing channels to promote their services.
Teknologi Dakwah Pencegahan Patologi Sosial Di Blok Marsela Kab. MTB Provinsi Maluku
Authors: Tuanani Ismail , Syarifudin Syarifudin 
Published: April 2019

Penelitian ini memotret isu teknologi dakwah dalam mencegah patologi sosial di tambang migas blok Marsela Kabupaten Maluku Tenggara. Penerapan teknologi dakwah di masjid dan gereja di Saumlaki menggunakan dakwah multikultural untuk merawat tujuan hidup, proses integrasi, proses adabtasi, dan merawat keyakinan masyarakat migran untuk menyesuaikan dengan budaya lokal setempat. Standar kompetensi yang dapat menjadi mubalig harmoni sosial di kawasan industri tambang migas perlu memiliki kecerdasan AISYATEK (Kecerdasan Aqidah, Intelektual, Syari’ah, dan Teknologi entrepreneurship), sebagai modal dan kekuatan untuk memberikan pencerahan spiritual untuk merawat harmoni sosial yang adil sebagai kekuatan dan ketahanan sosial di kawasan tambang migas di blok Marsela. Rekomendasi dari penelitian ini mendorong lahirnya PERDA pencegahan patologi sosial, konvensi materi khutbah di masjid, gereja untuk mencegah patologi sosial akibat perubahan demografi di MTB sebagai pusat ekplorasi migas di blok Masela. Pemuka agama dalam mendesain materi dakwah untuk menjaga, merawat ketahanan sosial dan mencegah terjadinya patologi sosial pada masyarakat multikultural di blok Marsela.
Kata Kunci: Teknologi, Dakwah, Patologi Sosial
Pesona Kurikulum SMP Islam Terpadu ‘Al-Qalam’ Kota Kendari
Authors: Marannu Baso 
Published: April 2019

Tulisan ini adalah hasil penelitian kualitatif dengan berfokus pada Sekolah Menengah Pertama Islam Terpadu Al-Qalam Kota Kendari, khususnya pengembangan Kurikulum kekhasan bidang Pendidikan Agama Islam baik dalam pembelajaran sebagai kurikulum inti dan kurikulum lokal. Hasil penelitian ini menyimpulkan bahwa Landasan, komponen dan Prinsip pengembangan kurikulum Pendidikan Agama dan keagamaan di SMP IT Al-Qalam Kendari dikembangkan dari inovasi dan kreatifitas pengelola sekolah secara mandiri yang diajarkan pada peserta didik baik secara monolitik maupun holistik (integratif) yang disusun oleh Pendidik dan Tenaga Kependidikan di SMP-IT ‘Al-Qalam’ Kota Kendari dan atau mengadopsi dari kurikulum yang disepakati oleh sekolah-sekolah Islam Terpadu di Indonesia yang terhimpun dalam Jaringan Sekolah Islam Terpadu (JSIT) di Indonesia. Kapasitas Pendidik yang mengajarkan pendidikan agama dan keagamaan baik secara monolitik maupun integratif sudah baik namun kapabilitasnya masih perlu dikembangkan. Rekomendasi dari penelitian ini diantaranya perlunya pemerintah terutama Kementerian Agama untuk mengkaji secara mendalam pola pengembangan kurikulum pendidikan agama dan keagamaan yang diterapkan di SMP IT secara umum terutama nilai budaya yang berkearifan lokal dan rasa nasionalisme, sesuai dengan tingkatan psikologi perkembangan anak dan tujuan pendidikan secara nasional, termasuk memberikan pelatihan bagi pengelola SMP IT untuk meningkatkan Kapabilitasnya.
Peran Orang Arab Dalam Pendidikan Keagamaan di Kabupaten Maros
Authors: Hamid Wardiah 
Published: April 2019

Sejarah telah mencatat bahwa pembawa Islam ke wilayah Nusantara adalah para pedagang dan mubalig dari negeri Arab. Mereka sangat berjasa dalam penyebaran dan pengembangan agama Islam di Indonesia. Kemudian membentuk pemukiman di sepanjang wilayah di Nusantara. Keberadaan mereka di Sulawesi Selatan begitu urgen untuk ditelusuri. Penelitian ini akan mencoba untuk mendeteksi keberadaan mereka di kabupaten Maros. Untuk itu rumusan masalahnya adalah bagaimana gambaran persebaran keturunan orang Arab kabupaten Maros dan bagaimanasistem kelembagaan yang dibangun oleh keturunan Arab. Pendekatan yang dilakukan dalam penelitian ini adalah kualitatif deskriftip. Hasil dari penelitian ini menunjukan keturunan Arab yang masih eksis sampai sekarang diantaranyAl Hamid, Al Idrus, Al qadri, Al Habsyi, bin Syihab, Al Mahdali, bi Faqih, Alwi dan Aidit, Assaggaf, Aidit, Al Idrus.Dan beberapa diantara mereka mengelola lembaga Pendidikan keagamaan di Sulawesi Selatan. Di Maros ada tarekat Khalwatiyah Yusuf mursyidnya adalahn marga Assegaf yang tetap eksis sampai sekarang.