bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bedside clinical neurologic assessment utilisation in paediatric cardiac intensive care units
Authors: Kirschen Matthew P , Blinder Josh , Dewitt Aaron , Snyder Megan , Ichord Rebecca , Berg Robert A , Nadkarni Vinay , Topjian Alexis 
Published: October 2018

AbstractIntroductionNeurodevelopmental disabilities in children with CHD can result from neurologic injury sustained in the cardiac ICU when children are at high risk of acute neurologic injury. Physicians typically order and specify frequency for serial bedside nursing clinical neurologic assessments to evaluate patients’ neurologic status.Materials and methodsWe surveyed cardiac ICU physicians to understand how these assessments are performed, and the attitudes of physicians on the utility of these assessments. The survey contained questions regarding assessment elements, assessment frequency, communication of neurologic status changes, and optimisation of assessments.ResultsSurveys were received from 50 institutions, with a response rate of 86%. Routine clinical neurologic assessments were reported to be performed in 94% of institutions and standardised in 56%. Pupillary reflex was the most commonly reported assessment. In all, 77% of institutions used a coma scale, with Glasgow Coma Scale being most common. For patients with acute brain injury, 82% of institutions reported performing assessments hourly, whereas assessment frequency was more variable for low-risk and high-risk patients without overt brain injury. In all, 84% of respondents thought their current practice for assessing and monitoring neurologic status was suboptimal. Only 41% felt that the Glasgow Coma Scale was a valuable tool for assessing neurologic function in the cardiac ICU, and 91% felt that a standardised approach to assessing pre-illness neurologic function would be valuable.ConclusionsRoutine nursing neurologic assessments are conducted in most surveyed paediatric cardiac ICUs, although assessment characteristics vary greatly between institutions. Most clinicians rated current neurologic assessment practices as suboptimal.
Executive Functioning Correlates With Communication Ability in Youth With Histories of Heavy Prenatal Alcohol Exposure
Authors: Doyle Lauren R. , Moore Eileen M. , Coles Claire D. , Kable Julie A. , Sowell Elizabeth R. , Wozniak Jeffrey R. , Jones Kenneth L. , Riley Edward P. , Mattson Sarah N. ,   the CIFASD
Published: October 2018

AbstractObjectives: Caregivers of youth with heavy prenatal alcohol exposure report impaired communication, which can significantly impact quality of life. Using data collected as part of the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), we examined whether cognitive variables predict communication ability of youth with histories of heavy prenatal alcohol exposure. Methods: Subjects (ages 10–16 years) comprised two groups: adolescents with heavy prenatal alcohol exposure (AE) and non-exposed controls (CON). Selected measures of executive function (NEPSY, Delis-Kaplan Executive Function System), working memory (CANTAB), and language were tested in the child, while parents completed communication ratings (Vineland Adaptive Behavior Scales – Second Edition). Separate multiple regression analyses determined which cognitive domains predicted communication ability. A final, global model of communication comprised the three cognitive models. Results: Spatial Working Memory and Inhibition significantly contributed to communication ability across groups. Twenty Questions performance related to communication ability in the CON group only while Word Generation performance related to communication ability in the AE group only. Effects remained significant in the global model, with the exception of Spatial Working Memory. Conclusions: Both groups displayed a relation between communication and Spatial Working Memory and Inhibition. Stronger communication ability related to stronger verbal fluency in the AE group and Twenty Questions performance in the CON group. These findings suggest that alcohol-exposed adolescents may rely more heavily on learned verbal storage or fluency for daily communication while non-exposed adolescents may rely more heavily on abstract thinking and verbal efficiency. Interventions aimed at aspects of executive function may be most effective at improving communication ability of these individuals. (JINS, 2018, 24, 1026–1037)
Enhancing Care
Authors: Manea Teodora 
Published: October 2018

AbstractIf moral enhancement is possible, the caring capacity of human beings should be considered one of the first and most important traits for augmentation. To assess the plausibility of enhancing care, I will explore how the concept and its associated human dispositions are socially constructed, and identify some of the critical points and complexities. Scientific advances regarding neuro-enhancing substances that allegedly make humans more caring will be considered and assessed against the main principles that govern the ethics of care approach. I argue that given the relational and contextual nature of care, its enhancement, if targeted at the individual level, can be more disadvantageous than helpful, by overlooking the “webs of care” people are situated in, and the role of social institutions in shaping behaviours, duties, attitudes, and principles.
Moral-Epistemic Enhancement
Authors: Paulo Norbert 
Published: October 2018

AbstractThe idea of using biomedical means to make people more likely to behave morally may have a certain appeal. However, it is very hard to find two persons – let alone two moral philosophers – who agree on what it means to be moral or to act morally. After discussing some of the proposals for moral enhancements that all ethicists could agree on, I engage more closely with the recent idea of “procedural moral enhancement” that aims at improving deliberative processes instead of particular moral views, motivations, or dispositions. I argue that it is better understood as a contribution to moral epistemology and should thus be labeled “moral-epistemic enhancement”. I then defend perspective-taking as a moral epistemic capacity which can be enhanced by both traditional and non-traditional biomedical means; a capacity which almost always contributes to the epistemic value of moral decision-making. Perspective-taking seems to be an uncontroversial non-trivial capacity for moral decision-making reasonably widely shared by proponents of ethical beliefs within the academic community. The enhancement of this capacity is thus a good candidate for an uncontroversial non-trivial moral enhancement.
Moral Enhancement, Instrumentalism, and Integrative Ethical Education
Authors: Turchi Giuseppe 
Published: October 2018

AbstractIn this chapter I will discuss some of the arguments presented inUnfit for the Future, where the authors stress the necessity of moral enhancement to prevent a global catastrophe. Persson and Savulescu promote a reductionistic view of moral intuitions suggesting that oxytocin, serotonin, and genetic treatments could save humanity from the perils of contemporary liberalism, weapons of mass destruction, and uncontrolled pollution. I will contend that although we need a moral enhancement it cannot be a brute manipulation of our biology but something where human plasticity is seen as paramount. Following the lesson of Dewey's instrumentalism, I advocate a non-reductionistic, pluralistic view where neuroscientific data may be used to develop a more effective moral pedagogy. In my opinion, this prospect is currently much more feasible (and less risky) than a hypothetical mass psycho-civilisation created using drugs and electrodes.
DrugsandHugs: Stimulating Moral Dispositions as a Method of Moral Enhancement
Authors: Klincewicz Michał , Frank Lily Eva , Sokólska Marta 
Published: October 2018

AbstractAdvocates of moral enhancement through pharmacological, genetic, or other direct interventions sometimes explicitly argue, or assume without argument, that traditional moral education and development is insufficient to bring about moral enhancement. Traditional moral education grounded in a Kohlbergian theory of moral development is indeed unsuitable for that task; however, the psychology of moral development and education has come a long way since then. Recent studies support the view that moral cognition is a higher-order process, unified at a functional level, and that a specific moral faculty does not exist. It is more likely that moral cognition involves a number of different mechanisms, each connected to other cognitive and affective processes. Taking this evidence into account, we propose a novel, empirically informed approach to moral development and education, in children and adults, which is based on a cognitive-affective approach to moral dispositions. This is an interpretative approach that derives from the cognitive-affective personality system (Mischel and Shoda, 1995). This conception individuates moral dispositions by reference to the cognitive and affective processes that realise them. Conceived of in this way, moral dispositions influence an agent's behaviour when they interact with situational factors, such as mood or social context. Understanding moral dispositions in this way lays the groundwork for proposing a range of indirect methods of moral enhancement, techniques that promise similar results as direct interventions whilst posing fewer risks.
Should We Biochemically Enhance Sexual Fidelity?
Authors: Arrell Robbie 
Published: October 2018

AbstractIn certain corners of the moral enhancement debate, it has been suggested we ought to consider the prospect of supplementing conventional methods of enhancing sexual fidelity (e.g. relationship counselling, moral education, self-betterment, etc.) with biochemical fidelity enhancement methods. In surveying this argument, I begin from the conviction that generally-speaking moral enhancement ought to expectably attenuate (or at least not exacerbate) vulnerability. Assuming conventional methods of enhancing sexual fidelity are at least partially effective in this respect – e.g., that relationship counselling sometimes successfully attenuates the particular vulnerability victims of infidelity feel – then presumably the case for supplementing conventional methods with biochemical methods turns, in part, on the claim that doing so will better promote attenuation of victim vulnerability.In this chapter I argue that on a sufficiently sophisticated conception of what this vulnerability consists in, biochemical methods of enhancing fidelity will not expectably attenuate victims’ vulnerability. Moreover, when combined with conventional methods, biochemical methods will predictably tend to undermine whatever attenuation conventional methods expectably promote in that respect. Thus, I conclude that couples committed to saving their relationship following an instance of sexual infidelity have reason to prefer conventional methods of enhancing sexual fidelity sans biochemical methods to conventional methods plus biochemical methods.
Association between fast-food consumption and lifestyle characteristics in Greek children and adolescents; results from the EYZHN (National Action for Children’s Health) programme
Authors: Tambalis Konstantinos D , Panagiotakos Demosthenes B , Psarra Glyceria , Sidossis Labros S 
Published: October 2018

AbstractObjectiveTo examine the prevalence of fast-food consumption and the association between fast food and lifestyle factors in a representative sample of children and adolescents.DesignCross-sectional, observational study. Fast-food consumption and dietary habits were evaluated using questionnaires (KIDMED index). Anthropometric and physical fitness measurements were obtained by trained investigators. Physical activity (PA) status, sedentary activities and sleeping habits were assessed through self-completed questionnaires.SettingGreece.SubjectsPopulation data derived from a school-based health survey (EYZHN programme) carried out in 2015 on 177 091 (51 % boys) children aged 8–17 years.ResultsA greater proportion of boysv. girls (23·3v. 15·7 %,P<0·001) and of adolescentsv. children (26·9v. 17·1 %,P<0·001) reported they consume fast foods >1 time/week. Frequent fast-food consumption was strongly correlated with unhealthy dietary habits such as skipping breakfast and consuming sweets/candy regularly. Adjusting for several covariates, insufficient dietary habits, insufficient (<8–9 h/d) sleep, inadequate PA levels and increased screen time increased the odds (95 % CI) of being a frequent fast-food consumer by 77 % (0·218, 0·234), 30 % (1·270, 1·338), 94 % (1·887, 1·995) and 32 % (1·287, 1·357), respectively. Being overweight/obese or centrally obese did not correlate with frequency of fast-food consumption.ConclusionsFrequent fast-food consumption was associated with an unhealthy lifestyle profile among children and adolescents. The findings support the development of interventions to help children adopt healthier dietary habits.
Systematic establishment of colour descriptor states through image-based phenotyping
Authors: Gentallan Renerio P. , Altoveros Nestor C. , Borromeo Teresita H. , Endonela Leah E. , Hay Fiona R. , Lalusin Antonio G. , Reaño Consorcia E. , Yoshioka Yosuke 
Published: October 2018

AbstractA systematic method for determining colour descriptor states using image analysis is proposed using pili (Canarium ovatum) as a model. Kernel images of 52 pili accessions from the core collection of the Institute of Crop Science and National Plant Genetic Resources Laboratory, University of the Philippines Los Baños were captured using a calibrated VideometerLab 3 setup. Colour descriptor states were derived from the average International Commission on Illumination lightness (L*), green–red (a*) and blue–yellow (b*) colour component values. Cluster analysis and subsequent colour-parameter averaging per cluster were performed to produce representative colour values of descriptor states. The Euclidian distance (Delta E) of 3.5 was used to cut the cluster into readily distinguishable colour differences resulting to three descriptor states – light brown, brown and dark brown. Continuous colour variation of brown colour was observed indicating a possible quantitative nature of the trait. The use of delta E in elucidating the descriptor lists served as a gauge in successfully identifying distinguishable variations between colours. The method described can be applied to the elucidation of colour descriptor states of all parts of the plant of all crop species.
TdIF1: a putative oncogene in NSCLC tumor progression
Authors: Zhang Yujuan , Wang Zhigang , Huang Yanqing , Ying Muying , Wang Yifan , Xiong Juan , Liu Qi , Cao Fan , Joshi Rakesh , Liu Yanling , Xu Derong , Zhang Meng , Yuan Keng , Zhou Nanjin , Koropatnick James , Min Weiping 
Published: October 2018

AbstractTdT-interacting factor 1 (TdIF1) is a ubiquitously expressed DNA- and protein-binding protein that directly binds to terminal deoxynucleotidyl transferase (TdT) polymerase. Little is known about the functional role of TdIF1 in cancer cellular signaling, nor has it previously been identified as aberrant in any type of cancer. We report here for the first time that TdIF1 is abundantly expressed in clinical lung cancer patients and that high expression of TdIF1 is associated with poor patient prognosis. We further established that TdIF1 is highly expressed in human non-small cell lung cancer (NSCLC) cell lines compared to a normal lung cell line. shRNA-mediated gene silencing of TdIF1 resulted in the suppression of proliferation and anchorage-independent colony formation of the A549 adenocarcinoma cell line. Moreover, when these TdIF1-silenced cells were used to establish a mouse xenograft model of human NSCLC, tumor size was greatly reduced. These data suggest that TdIF1 is a potent regulator of lung tumor development. Several cell cycle-related and tumor growth signaling pathways, including the p53 and HDAC1/2 pathways, were identified as participating in the TdIF1 signaling network by in silico analysis. Microarray, transcriptome and protein-level analyses validated p53 and HDAC1/2 modulation upon TdIF1 downregulation in an NSCLC cellular model. Moreover, several other cell cycle regulators were affected at the transcript level by TdIF1 silencing, including an increase in CDKN1A/p21 transcripts. Taken together, these results indicate that TdIF1 is a bona fide tumor-promoting factor in NSCLC and a potential target for therapy.
NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
Authors: Maghames Chantal M. , Lobato-Gil Sofia , Perrin Aurelien , Trauchessec Helene , Rodriguez Manuel S. , Urbach Serge , Marin Philippe , Xirodimas Dimitris P. 
Published: October 2018

AbstractSpatial management of stress-induced protein aggregation is an integral part of the proteostasis network. Protein modification by the ubiquitin-like molecule NEDD8 increases upon proteotoxic stress and it is characterised by the formation of hybrid NEDD8/ubiquitin conjugates. However, the biological significance of this response is unclear. Combination of quantitative proteomics with biological analysis shows that, during proteotoxic stress, NEDDylation promotes nuclear protein aggregation, including ribosomal proteins as a major group. This correlates with protection of the nuclear Ubiquitin Proteasome System from stress-induced dysfunction. Correspondingly, we show that NEDD8 compromises ubiquitination and prevents targeting and processing of substrates by the proteasome. Moreover, we identify HUWE1 as a key E3-ligase that is specifically required for NEDDylation during proteotoxic stress. The study reveals a specific role for NEDD8 in nuclear protein aggregation upon stress and is consistent with the concept that transient aggregate formation is part of a defence mechanism against proteotoxicity.
Identifying an efficient, thermally robust inorganic phosphor host via machine learning
Authors: Zhuo Ya , Mansouri Tehrani Aria , Oliynyk Anton O. , Duke Anna C. , Brgoch Jakoah 
Published: October 2018

AbstractRare-earth substituted inorganic phosphors are critical for solid state lighting. New phosphors are traditionally identified through chemical intuition or trial and error synthesis, inhibiting the discovery of potential high-performance materials. Here, we merge a support vector machine regression model to predict a phosphor host crystal structure’s Debye temperature, which is a proxy for photoluminescent quantum yield, with high-throughput density functional theory calculations to evaluate the band gap. This platform allows the identification of phosphors that may have otherwise been overlooked. Among the compounds with the highest Debye temperature and largest band gap, NaBaB9O15shows outstanding potential. Following its synthesis and structural characterization, the structural rigidity is confirmed to stem from a unique corner sharing [B3O7]5–polyanionic backbone. Substituting this material with Eu2+yields UV excitation bands and a narrow violet emission at 416 nm with a full-width at half-maximum of 34.5 nm. More importantly, NaBaB9O15:Eu2+possesses a quantum yield of 95% and excellent thermal stability.
Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
Authors: Choi Seung-Chul , Titov Anton A. , Abboud Georges , Seay Howard R. , Brusko Todd M. , Roopenian Derry C. , Salek-Ardakani Shahram , Morel Laurence 
Published: October 2018

AbstractFollicular helper T (TFH) cells are expanded in systemic lupus erythematosus, where they are required to produce high affinity autoantibodies. Eliminating TFHcells would, however compromise the production of protective antibodies against viral and bacterial pathogens. Here we show that inhibiting glucose metabolism results in a drastic reduction of the frequency and number of TFHcells in lupus-prone mice. However, this inhibition has little effect on the production of T-cell-dependent antibodies following immunization with an exogenous antigen or on the frequency of virus-specific TFHcells induced by infection with influenza. In contrast, glutaminolysis inhibition reduces both immunization-induced and autoimmune TFHcells and humoral responses. Solute transporter gene signature suggests different glucose and amino acid fluxes between autoimmune TFHcells and exogenous antigen-specific TFHcells. Thus, blocking glucose metabolism may provide an effective therapeutic approach to treat systemic autoimmunity by eliminating autoreactive TFHcells while preserving protective immunity against pathogens.
Large increase in global storm runoff extremes driven by climate and anthropogenic changes
Authors: Yin Jiabo , Gentine Pierre , Zhou Sha , Sullivan Sylvia C. , Wang Ren , Zhang Yao , Guo Shenglian 
Published: October 2018

AbstractWeather extremes have widespread harmful impacts on ecosystems and human communities with more deaths and economic losses from flash floods than any other severe weather-related hazards. Flash floods attributed to storm runoff extremes are projected to become more frequent and damaging globally due to a warming climate and anthropogenic changes, but previous studies have not examined the response of these storm runoff extremes to naturally and anthropogenically driven changes in surface temperature and atmospheric moisture content. Here we show that storm runoff extremes increase in most regions at rates higher than suggested by Clausius-Clapeyron scaling, which are systematically close to or exceed those of precipitation extremes over most regions of the globe, accompanied by large spatial and decadal variability. These results suggest that current projected response of storm runoff extremes to climate and anthropogenic changes may be underestimated, posing large threats for ecosystem and community resilience under future warming conditions.
APOE ε2 is associated with increased tau pathology in primary tauopathy
Authors: Zhao Na , Liu Chia-Chen , Van Ingelgom Alexandra J. , Linares Cynthia , Kurti Aishe , Knight Joshua A. , Heckman Michael G. , Diehl Nancy N. , Shinohara Mitsuru , Martens Yuka A. , Attrebi Olivia N. , Petrucelli Leonard , Fryer John D. , Wszolek Zbigniew K. , Graff-Radford Neill R. , Caselli Richard J. , Sanchez-Contreras Monica Y. , Rademakers Rosa , Murray Melissa E. , Koga Shunsuke , Dickson Dennis W. , Ross Owen A. , Bu Guojun 
Published: October 2018

AbstractApolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease mainly by modulating amyloid-β pathology. APOE ε4 is also shown to exacerbate neurodegeneration and neuroinflammation in a tau transgenic mouse model. To further evaluate the association of APOE genotype with the presence and severity of tau pathology, we express human tau via an adeno-associated virus gene delivery approach in human APOE targeted replacement mice. We find increased hyperphosphorylated tau species, tau aggregates, and behavioral abnormalities in mice expressing APOE ε2/ε2. We also show that in humans, the APOE ε2 allele is associated with increased tau pathology in the brains of progressive supranuclear palsy (PSP) cases. Finally, we identify an association between the APOE ε2/ε2 genotype and risk of tauopathies using two series of pathologically-confirmed cases of PSP and corticobasal degeneration. Our data together suggest APOE ε2 status may influence the risk and progression of tauopathy.