bluuebunny/crossref_metadata_2025_split huggingface dataset:
Balance Testing Following Concussion: Postural Sway versus Complexity Index
Authors: Purkayastha Sushmita , Adair Heather , Woodruff Amanda , Ryan Laurence J. , Williams Benjamin , James Eric , Bell Kathleen R. 
Published: February 2019

BackgroundAlthough postural control deficits are common following a concussion, the current clinical assessments for postural control tend to resolve within 3 to 10 days after injury. There is a lack of sensitive tools to examine subtle changes in postural control during the recovery phase following sports‐related concussion. Only a limited number of studies have examined nonlinear dynamics of postural control; no study has examined this metric longitudinally during the recovery phase following a sports‐related concussion.ObjectiveTo examine sway and complexity index of postural control in collegiate athletes during day 3, day 21, and day 90 following a concussion and compare them with noninjured controls.DesignProspective longitudinal case‐control study.SettingUniversity cerebrovascular research laboratory.ParticipantsThirty‐one male and female collegiate athletes on day 3 following a concussion. Twenty‐eight athletes returned on day 21, and 21 completed assessments on day 90. Twenty‐nine sports‐matched noninjured controls.MethodsCenter of pressure (COP) measurements obtained during 60‐second quiet standing on a force plate system with either eyes opened or closed. Postural sway was estimated as range and variability of COP in the anteroposterior (AP) and mediolateral planes.Main Outcome MeasurementsComplexity index of AP COP utilizing multiscale entropy analysis.ResultsPostural sway measured as AP range (P = .03) and variability (P = .04) during quiet standing with eyes closed were higher on day 3 compared to the controls. Postural sway in the concussed group was comparable to the noninjured controls by day 21 postinjury. However, postural control dynamics utilizing complexity index was lower on day 3 (P < .001) and persisted on day 21 (P < .006) and day 90 (P < .02), despite resolution of abnormal postural sway 21 days postinjury.ConclusionComplexity index utilizing nonlinear dynamics might be a more sensitive objective biomarker for examining postural control following a concussion, with implications for return‐to‐play and interventions. Future studies with a larger sample size are needed to validate this finding.Clinical Trial NumberNCT02754206.Level of EvidenceIII.
Exotic holographic dispersion
Authors: Gran U. , Tornsö M. , Zingg T. 
Published: February 2019

Abstract

For strongly interacting systems, where perturbation theory is not applicable, holographic duality is a powerful framework for computing e.g. dispersion relations. Using the standard Reissner-Nordström black hole as a holographic model for a (strange) metal, we obtain exotic dispersion relations for both plasmon modes and quasinormal modes for certain intermediate values of the charge of the black hole.
The obtained dispersion relations show dissipative behavior which we compare to the generic expectations from the Caldeira-Leggett model for quantum dissipation. Based on these considerations, we investigate how holography can predict higher order corrections for strongly coupled physics.
Lagrangian transport by vertically confined internal gravity wavepackets
Authors: van den Bremer T. S. , Yassin H. , Sutherland B. R. 
Published: February 2019

We examine the flows induced by horizontally modulated, vertically confined (or guided), internal wavepackets in a stratified, Boussinesq fluid. The wavepacket induces both an Eulerian flow and a Stokes drift, which together determine the Lagrangian transport of passive tracers. We derive equations describing the wave-induced flows in arbitrary stable stratification and consider four special cases: a two-layer fluid, symmetric and asymmetric piecewise constant (‘top-hat’) stratification and, more representative of the ocean, exponential stratification. In a two-layer fluid, the Stokes drift is positive everywhere with the peak value at the interface, whereas the Eulerian flow is negative and uniform with depth for long groups. Combined, the net depth-integrated Lagrangian transport is zero. If one layer is shallower than the other, the wave-averaged interface displaces into that layer making the Eulerian flow in that layer more negative and the Eulerian flow in the opposite layer more positive so that the depth-integrated Eulerian transports are offset by the same amount in each layer. By contrast, in continuous stratification the depth-integrated transport due to the Stokes drift and Eulerian flow are each zero, but the Eulerian flow is singular if the horizontal phase speed of the induced flow equals the group velocity of the wavepacket, giving rise to a single resonance in uniform stratification (McIntyre, J. Fluid Mech., vol. 60, 1973, pp. 801–811). In top-hat stratification, this single resonance disappears, being replaced by multiple resonances occurring when the horizontal group velocity of the wavepacket matches the horizontal phase speed of higher-order modes. Furthermore, if the stratification is not vertically symmetric, then the Eulerian induced flow varies as the inverse squared horizontal wavenumber for shallow waves, the same as for the asymmetric two-layer case. This ‘infrared catastrophe’ also occurs in the case of exponential stratification suggesting significant backward near-surface transport by the Eulerian induced flow for modulated oceanic internal modes. Numerical simulations are performed confirming these theoretical predictions.
Comparison of selective hydrolysis of α-lactalbumin by acid Protease A and Protease M as alternative to pepsin: potential for β-lactoglobulin purification in whey proteins
Authors: Lisak Jakopović Katarina , Cheison Seronei Chelulei , Kulozik Ulrich , Božanić Rajka 
Published: February 2019

AbstractThe experiments reported in this research paper examine the potential of digestion using acidic enzymes Protease A and Protease M to selectively hydrolyse α-lactalbumin (α-La) whilst leaving β-lactoglobulin (β-Lg) relatively intact. Both enzymes were compared with pepsin hydrolysis since its selectivity to different whey proteins is known. Analysis of the hydrolysis environment showed that the pH and temperature play a significant role in determining the best conditions for achievement of hydrolysis, irrespective of which enzyme was used. Whey protein isolate (WPI) was hydrolysed using pepsin, Acid Protease A and Protease M by randomized hydrolysis conditions. Reversed-phase high performance liquid chromatography was used to analyse residual proteins. Regarding enzyme selectivity under various milieu conditions, all three enzymes showed similarities in the reaction progress and their potential for β-Lg isolation.
Patient involvement in reflective multicriteria decision analysis to assist decision making in oncology
Authors: Badia Xavier , Aguarón Alfonso , Fernández Ana , Gimón Antonia , Nafria Begoña , Gaspar Bernard , Guarga Laura , Gálvez María , Fuentes Marta , Paco Noelia , Saldaña Roberto 
Published: February 2019

AbstractObjectivesPatient involvement in drug evaluation decision making is increasing. The aim of the current study was to develop a multi-criteria decision analysis (MCDA) framework that would enable the inclusion of the patient perspective in the selection of appropriate criteria for MCDAs being used in the value assessments of oncologic drugs.MethodsA literature review was conducted to identify and define criteria used in drug assessments from patient perspectives. The Evidence and Value: Impact on Decision Making methodology was used to develop a MCDA framework. Identified criteria were discussed by a sample of oncology patient association representatives who decided which criteria were important from patient perspectives. Selected criteria were rated by importance. The preliminary MCDA framework was tested through the assessment of a hypothetical oncology treatment. A discussion was carried out to agree on a final pilot MCDA framework.ResultsTwenty-two criteria were extracted from the literature review. After criteria discussion, sixteen criteria remained. The most important criteria were comparative patient reported outcomes (PRO), comparative efficacy and disease severity. After the discussion generated by the scoring of the hypothetical oncology treatment, the final pilot MCDA framework included seven quantitative criteria (“disease severity”, “unmet needs”, “comparative efficacy / effectiveness”, “comparative safety / tolerability”, “comparative PROs”, “contribution of oncological innovation”) and one contextual criterion (“population priorities and access”).ConclusionsThe present study developed a pilot reflective MCDA framework that could increase patient's capability to participate in the decision-making process by providing systematic drug assessments from the patient perspective.
Seafood intake and the development of obesity, insulin resistance and type 2 diabetes
Authors: Liaset Bjørn , Øyen Jannike , Jacques Hélène , Kristiansen Karsten , Madsen Lise 
Published: February 2019

AbstractWe provide an overview of studies on seafood intake in relation to obesity, insulin resistance and type 2 diabetes. Overweight and obesity development is for most individuals the result of years of positive energy balance. Evidence from intervention trials and animal studies suggests that frequent intake of lean seafood, as compared with intake of terrestrial meats, reduces energy intake by 4–9 %, sufficient to prevent a positive energy balance and obesity. At equal energy intake, lean seafood reduces fasting and postprandial risk markers of insulin resistance, and improves insulin sensitivity in insulin-resistant adults. Energy restriction combined with intake of lean and fatty seafood seems to increase weight loss. Marinen-3 PUFA are probably of importance throughn-3 PUFA-derived lipid mediators such as endocannabinoids and oxylipins, but other constituents of seafood such as the fish proteinper se, trace elements or vitamins also seem to play a largely neglected role. A high intake of fatty seafood increases circulating levels of the insulin-sensitising hormone adiponectin. As compared with a high meat intake, high intake of seafood has been reported to reduce plasma levels of the hepatic acute-phase protein C-reactive protein level in some, but not all studies. More studies are needed to confirm the dietary effects on energy intake, obesity and insulin resistance. Future studies should be designed to elucidate the potential contribution of trace elements, vitamins and undesirables present in seafood, and we argue that stratification into responders and non-responders in randomised controlled trials may improve the understanding of health effects from intake of seafood.
Neuropsychological Findings in Hamamy Syndrome: A Clinical Case Report
Authors: Roukoz Cynthia , Kanj Rama , Maalouf Fadi T. , Zeinoun Pia 
Published: February 2019

AbstractThis study, reports for the first time, the neuropsychological profile of a child with Hamamy syndrome—a rare genetic disorder with only five published cases (Buget, Canbolat, Akgul, & Kucukay, 2015). The patient was seen for a neuropsychological evaluation at ages 6 and 7, at the American University of Beirut Medical Center. Procedures included an extended clinical interview with the parent, behavioral observations, formal tests, and a series of parental rating scales. Patient was found to have relatively spared nonverbal intelligence, borderline-impaired language, and clinically impaired verbal reasoning, attention, and motor coordination. Additionally, he showed clinically significant concerns with behavioral regulation, metacognition, attention-deficit, and hyperactivity/impulsivity. The patient was diagnosed with a DSM-V Language Disorder, Speech Sound Disorder, and Attention Deficit/Hyperactivity Disorder, combined presentation, in the context of low-average intelligence. At follow-up, the neuropsychological profile was consistent, albeit improvement was noted following pharmacotherapy. This is the first published report that describes the neuropsychological functions of Hamamy syndrome. We make recommendations for early identification of cognitive strengths and weaknesses, and interventions to address them. Future research should evaluate additional functions such as memory and social/emotional development. (JINS, 2019,25, 336–342)
Combined Processing of Facial and Vocal Emotion in Remitted Patients With Bipolar I Disorder
Authors: Hoertnagl Christine M. , Biedermann Falko , Yalcin-Siedentopf Nursen , Welte Anna-Sophia , Frajo-Apor Beatrice , Deisenhammer Eberhard A. , Hausmann Armand , Kemmler Georg , Muehlbacher Moritz , Hofer Alex 
Published: February 2019

AbstractObjectives:Bipolar disorder (BD) is associated with impairments in facial emotion and emotional prosody perception during both mood episodes and periods of remission. To expand on previous research, the current study investigated cross-modal emotion perception, that is, matching of facial emotion and emotional prosody in remitted BD patients.Methods:Fifty-nine outpatients with BD and 45 healthy volunteers were included into a cross-sectional study. Cross-modal emotion perception was investigated by using two subtests out of the Comprehensive Affective Testing System (CATS).Results:Compared to control subjects patients were impaired in matching sad (p< .001) and angry emotional prosody (p= .034) to one of five emotional faces exhibiting the corresponding emotion and significantly more frequently matched sad emotional prosody to happy faces (p< .001) and angry emotional prosody to neutral faces (p= .017). In addition, patients were impaired in matching neutral emotional faces to the emotional prosody of one of three sentences (p= .006) and significantly more often matched neutral faces to sad emotional prosody (p= .014).Conclusions:These findings demonstrate that, even during periods of symptomatic remission, patients suffering from BD are impaired in matching facial emotion and emotional prosody. As this type of emotion processing is relevant in everyday life, our results point to the necessity to provide specific training programs to improve psychosocial outcomes. (JINS, 2019,25, 336–342)
The implication of the hyperbolic discount model for the annuitisation decisions
Authors: Chen Anran , Haberman Steven , Thomas Stephen 
Published: February 2019

AbstractThe low demand for immediate annuities at retirement has been a long-standing puzzle. We show that a hyperbolic discount model can explain this behaviour and results in the attractiveness of long-term deferred annuities. With a set of benchmark assumptions, we find that retirees would be willing to pay a much higher price than the actuarial fair price for annuities with longer deferred periods. Moreover, if governments were to introduce a pre-commitment device which requires pensioners to make annuitisation decisions around 10 years before retirement, the take up rate of annuities could become higher.
The 19 September 2017 (Mw7.1) Intermediate‐Depth Mexican Earthquake: A Slow and Energetically Inefficient Deadly Shock
Authors: Mirwald Aron , Cruz‐Atienza Víctor M. , Díaz‐Mojica John , Iglesias Arturo , Singh Shri K. , Villafuerte Carlos , Tago Josué 
Published: February 2019

AbstractWe investigate dynamic source parameters of the Mw7.1 Puebla‐Morelos intermediate‐depth earthquake (h = 57 km) of 19 September 2017, which devastated Mexico City. Our simple, elliptical source model, coupled with a new Particle Swarm Optimization algorithm, revealed rupture propagation within the subducted Cocos plate, featuring a high stress drop (Δτ = 14.9±5.6 MPa) and a remarkably low radiation efficiency (ηr = 0.16 ± 0.09). Fracture energy was large (G = (1.04 ± 0.3) × 1016 J), producing a slow dissipative rupture (Vr/Vs = 0.34 ± 0.04) with scaling‐consistent radiated energy (Er = (1.8 ± 0.9)·1015 J) and energy‐moment ratio (Er/M0 = 3.2 × 10−5). About 84% of the available potential energy for the dynamic rupture was dissipated in the focal region, likely producing friction‐induced melts in the fault core of 0.2–1.2 cm width due to heat production (700–1200 °C temperature rise). Such source features seem to be a universal signature of intermediate‐depth earthquakes.
Carboxydotrophy potential of uncultivated Hydrothermarchaeota from the subseafloor crustal biosphere
Authors: Carr Stephanie A , Jungbluth Sean P , Eloe-Fadrosh Emiley A , Stepanauskas Ramunas , Woyke Tanja , Rappé Michael S , Orcutt Beth N 
Published: February 2019

Abstract
The exploration of Earth’s terrestrial subsurface biosphere has led to the discovery of several new archaeal lineages of evolutionary significance. Similarly, the deep subseafloor crustal biosphere also harbors many unique, uncultured archaeal taxa, including those belonging to Candidatus Hydrothermarchaeota, formerly known as Marine Benthic Group-E. Recently, Hydrothermarchaeota was identified as an abundant lineage of Juan de Fuca Ridge flank crustal fluids, suggesting its adaptation to this extreme environment. Through the investigation of single-cell and metagenome-assembled genomes, we provide insight into the lineage’s evolutionary history and metabolic potential. Phylogenomic analysis reveals the Hydrothermarchaeota to be an early-branching archaeal phylum, branching between the superphylum DPANN, Euryarchaeota, and Asgard lineages. Hydrothermarchaeota genomes suggest a potential for dissimilative and assimilative carbon monoxide oxidation (carboxydotrophy), as well as sulfate and nitrate reduction. There is also a prevalence of chemotaxis and motility genes, indicating adaptive strategies for this nutrient-limited fluid-rock environment. These findings provide the first genomic interpretations of the Hydrothermarchaeota phylum and highlight the anoxic, hot, deep marine crustal biosphere as an important habitat for understanding the evolution of early life.
Citrullination mediated by PPAD constrains biofilm formation in P. gingivalis strain 381
Authors: Vermilyea Danielle M. , Ottenberg Gregory K. , Davey Mary E. 
Published: February 2019

AbstractPorphyromonas gingivalis is the only known human-associated prokaryote that produces a peptidylarginine deiminase (PPAD), a protein-modifying enzyme that is secreted along with a number of virulence factors via a type IX secretion system (T9SS). While the function of PPAD in P. gingivalis physiology is not clear, human peptidylarginine deiminases are known to convert positively charged arginine residues within proteins to neutral citrulline and, thereby, impact protein conformation and function. Here, we report that the lack of citrullination in a PPAD deletion mutant (Δ8820) enhances biofilm formation. More Δ8820 cells attached to the surface than the parent strain during the early stages of biofilm development and, ultimately, mature Δ8820 biofilms were comprised of significantly more cell–cell aggregates and extracellular matrix. Imaging by electron microscopy discovered that Δ8820 biofilm cells secrete copious amounts of protein aggregates. Furthermore, gingipain-derived adhesin proteins, which are also secreted by the T9SS were predicted by mass spectrometry to be citrullinated and citrullination of these targets by wild-type strain 381 in vitro was confirmed. Lastly, Δ8820 biofilms contained more gingipain-derived adhesin proteins and more gingipain activity than 381 biofilms. Overall, our findings support the model that citrullination of T9SS cargo proteins known to play a key role in colonization, such as gingipain-derived adhesin proteins, is an underlying mechanism that modulates P. gingivalis biofilm development.
Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs
Authors: Jeffreys Laura N. , Poddar Harshwardhan , Golovanova Marina , Levy Colin W. , Girvan Hazel M. , McLean Kirsty J. , Voice Michael W. , Leys David , Munro Andrew W. 
Published: February 2019

AbstractFlavocytochrome P450 BM3 is a natural fusion protein constructed of cytochrome P450 and NADPH-cytochrome P450 reductase domains. P450 BM3 binds and oxidizes several mid- to long-chain fatty acids, typically hydroxylating these lipids at the ω-1, ω-2 and ω-3 positions. However, protein engineering has led to variants of this enzyme that are able to bind and oxidize diverse compounds, including steroids, terpenes and various human drugs. The wild-type P450 BM3 enzyme binds inefficiently to many azole antifungal drugs. However, we show that the BM3 A82F/F87V double mutant (DM) variant binds substantially tighter to numerous azole drugs than does the wild-type BM3, and that their binding occurs with more extensive heme spectral shifts indicative of complete binding of several azoles to the BM3 DM heme iron. We report here the first crystal structures of P450 BM3 bound to azole antifungal drugs – with the BM3 DM heme domain bound to the imidazole drugs clotrimazole and tioconazole, and to the triazole drugs fluconazole and voriconazole. This is the first report of any protein structure bound to the azole drug tioconazole, as well as the first example of voriconazole heme iron ligation through a pyrimidine nitrogen from its 5-fluoropyrimidine ring.
Tailoring the robust superhydrophobic silicon textures with stable photodetection properties
Authors: Hsiao Min , Chen Kai-Yu , Chen Chia-Yun 
Published: February 2019

AbstractSurface hydrophobicity of silicon with sound durability under mechanical abrasion is highly desirable for practical needs. However, the reported micro-pyramid/nanowires structures suffer from the saturation characteristics of contact angle at around 132 degree, which impede the promotions toward reaching the state of superhydrophobicity. The present study focuses on the realization of two-scale silicon hierarchical structures prepared with the facile, rapid and large-area capable chemical etching methods without the need of lithographic patterning. The designed structures, with the well combination of microscale inverted pyramids and nanowire arrays, dramatically lead to the increased wetting angle of 157.2 degree and contact-angle hysteresis of 9.4 degree. In addition, the robustness test reveals that these hierarchical textures possess the narrow contact-angle change of 4 degree responding to the varied pH values, and maintain a narrow deviation of 2 degree in wetting angle after experiencing the abrasion test. Moreover, the highly stable photodetection characteristics of such two-scale structures were identified, showing the reliable photocurrents with less than 3% of deviation under wide range of environmental humidity. By adopting a simple chemical treatment, the wetting control is demonstrated for reliable transition of superhydrophobicity and superhydrophilicity.