bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tops und Flops der Kopfschmerztherapie
Authors: Diener Hans-Christoph , Limmroth Volker , Gaul Charly 
Published: October 2019

ZUSAMMENFASSUNGDie Therapie akuter Migräneattacken und die Prophylaxe der Migräne wurde durch Fortschritte in den Erkenntnissen der Pathophysiologie der Migräne und die Entwicklung neuer Substanzklassen in den letzten 30 Jahren dramatisch verbessert. Dazu gehört die Einführung der Triptane. Antagonisten gegen Substanz-P waren allerdings nicht wirksam. In der Migräneprophylaxe waren neben den etablierten Medikamenten auch Topiramat und bei der chronischen Migräne Onabotulinumtoxin A wirksam. Neue Ansätze ergeben sich durch die neuen monoklonalen Antikörper gegen CGRP oder den CGRP-Rezeptor. Wichtige Fortschritte gab es in der Epidemiologie und Therapie des chronischen Kopfschmerzes durch Übergebrauch von Schmerz- oder Migränemittel. Patienten mit diesem Krankheitsbild sollten bevorzugt in Schwerpunktpraxen oder Kopfschmerzzentren behandelt werden.
Coronary Aneurysm: An Enigma Wrapped in a Mystery
Authors: Carino Davide , Agarwal Arvind , Singh Mrinal , Meadows Judith , Ziganshin Bulat A. , Elefteriades John A. 
Published: October 2019

AbstractCoronary aneurysms are defined as localized dilatations of the coronary arteries. In this review, we will analyze the most important aspects of this rare condition while trying to provide answers to the following questions: What is a coronary aneurysm? What causes coronary aneurysm? Do coronary aneurysms cause symptoms? Can coronary aneurysms rupture? How do we treat coronary aneurysms?
Native Aortic Arch Interruption in Adulthood: Surgical Management
Authors: Federici Duccio , Bichi Samuele , Montesi Gianfranco , Matiashvili David , Agostinis Cristina , Morzenti Cesare , Sironi Sandro , Galletti Lorenzo 
Published: October 2019

AbstractAortic coarctations in adults are mainly represented by recurrent critical narrowing at the site of previous surgical correction, or less frequently by native forms of complex obstructive malformations of the distal arch and isthmus. We present our experience with an unusual form of native adult aortic coarctation presenting as a complete interruption of the aortic arch.
The Clinical Impact of Imaging Surveillance and Clinic Visit Frequency after Acute Aortic Dissection
Authors: Chaddha Ashish , Eagle Kim A. , Patel Himanshu J. , Deeb G. Michael , Yang Bo , Harris Kevin M. , Braverman Alan C. , Hutchison Stuart , Evangelista Arturo , Fattori Rossella , Froehlich James B. , Nienaber Christoph A. , Isselbacher Eric M. , Montgomery Dan G. , Kline-Rogers Eva , Woznicki Elise , LaBounty Troy M. 
Published: October 2019

Background Guidelines recommend frequent follow-up after acute aortic dissection (AAD), but optimal rates of follow-up are not clear.
Methods We examined rates of imaging and clinic visits in 267 individuals surviving AAD during recommended intervals (≤1, > 1–3, > 3–6, > 6–12 months, then annually), frequency of adverse imaging findings, and the relationship between follow-up and mortality.
Results Type A and B AAD were noted in 46 and 54% of patients, respectively. Mean follow-up was 54.7 ± 13.3 months, with 52 deaths. Adverse imaging findings peaked at 6 to 12 months (5.6%), but rarely resulted in an intervention (3.4% peak at 6–12 months). Compared with those with less frequent imaging, patients with imaging for 33 to 66% of intervals (p = 0.22) or ≥66% of intervals (p = 0.77) had similar adjusted survival. In comparison to patients with fewer clinic visits, those with visits in 33 to 66% of intervals experienced lower adjusted mortality (hazards ratio: 0.47, 95% confidence interval: 0.23–0.97, p = 0.04), with no difference seen in those with ≥66% (vs. < 33%) interval visits (p = 0.47). Imaging at 6 to 12 months (vs. none) was associated with decreased adjusted mortality (hazards ratio: 0.50, 95% confidence interval: 0.27–0.91, p = 0.02), while imaging during other intervals, or clinic visits during any specific intervals, was not associated with a difference in mortality (p > 0.05 for each).
Conclusions Adverse imaging findings following AAD are common, but rarely require prompt intervention. Patients with the lowest and highest rates of clinic visits experienced increased mortality. While the overall rate of surveillance imaging did not correlate with mortality, adverse imaging findings and related interventions peaked at 6 to 12 months after AAD, and imaging during this time was associated with improved survival.
Clot Structure and Implications for Bleeding and Thrombosis
Authors: Mihalko Emily , Brown Ashley C. 
Published: October 2019

AbstractThe formation of a fibrin clot matrix plays a critical role in promoting hemostasis and wound healing. Fibrin dynamics can become disadvantageous in the formation of aberrant thrombus development. Structural characteristics of clots, such as fiber diameter, clot density, stiffness, or permeability, can determine overall clot integrity and functional characteristics that have implications on coagulation and fibrinolysis. This review examines known factors that contribute to changes in clot structure and the presence of structural clot changes in various disease states. These insights provide valuable information in forming therapeutic strategies for disease states where alterations in clot structure are observed. Additionally, the implications of structural changes in clot networks on bleeding and thrombus development in terms of disease states and clinical outcomes are also examined in this review.
Impact of Insurance Scheme on Adults’ Dental Check-Ups in a Developing Oral Health Care System
Authors: Bayat Fariborz , Vehkalahti Miira M , Zafarmand A. Hamid , Tala Heikki 
Published: October 2019

ABSTRACTObjectives: To find out the relationship between dental insurance and demand for dental care, the present study evaluated impact of insurance scheme on adults’ dental check-ups in a developing oral health care system.Methods: The target population included adults in the city of Tehran where the only telecommunication company provides 90% of the 1.9 million households with a fixed telephone. Of the 1531 subjects who answered the phone call, 224 were outside the target age (under 18), 67 said that they never had visited a dentist, and 221 refused to respond, leaving 1019 subjects in the final sample. Each interview lasted 15 minutes and was carried out using a structured questionnaire with fixed and open-ended questions.Results: 71% of the subjects reported having dental insurance and 16% having visited a dentist for a check-up; 55%, more women than men, reported having had a dental visit within the past 12 months.Conclusions: The present results revealed the positive relationship between insurance and demand for dental care. Those having dental insurance were more likely to go to check-ups despite their generally low rate found in this country with a developing oral health care system. In such countries, health insurance schemes should therefore include obligatory regular dental check-ups to emphasize prevention-oriented dental care. (Eur J Dent 2008;2:3-10)
Treatment of Anterior Dental Crossbite Using Bonded Resin-Composite Slopes: Case Reports
Authors: Bayrak Sule , Tunc Emine Sen 
Published: October 2019

ABSTRACTAnterior crossbite is the term used to describe an abnormal labiolingual relationship between one or more maxillary and mandibular incisor teeth. Different techniques have been used to correct anterior crossbite. This paper describes the use of bonded resin-composite slopes for the management of anterior crossbite in children in early mixed dentition.In each of the cases presented here, dental crossbite was corrected by applying a 3-4 mm bonded resin-composite slope to the incisal edge of the mandibular incisor with an angle 45° to the longitudinal axis of the tooth. Correction was achieved within 1-2 weeks with no damage to either the tooth or the marginal periodontal tissue. The procedure is a simple and effective method for treating
anterior dental crossbite. (Eur J Dent 2008;2:303-307)
Pre-Eruptive Coronal Resorption and Congenitally Missing Teeth in a Patient with Amelogenesis Imperfecta: A Case Report
Authors: Miloglu Ozkan , Karaalioglu Osman Fatih , Caglayan Fatma , Yesil Zeynep Duymus 
Published: October 2019

ABSTRACTThis clinical report describes a male with autosomal recessive generalized hypoplastic amelogenesis imperfecta. This case is unusual in coronal resorptions prior to tooth eruption. This finding has been reported in some cases of autosomal recessive, autosomal dominant and X linked amelogenesis imperfecta (AI). In reported cases, the defects were usually small and occurred in a maximum of 2 teeth per person. In our case, pre-eruptive coronal resorptions affected three second molar teeth from both jaws. On the other hand; congenitally missing teeth and malocclusion were present in this case. Recall evaluations at 3 month intervals occurred for a period of 2 years and then prosthodontic management began. (Eur J Dent 2009;3:140-144)
An Unusual Association of Odontomas with Primary Teeth
Authors: Yıldırım-Öz Gülsün , Tosun Gül , Kızıloğlu Dilek , Durmuş Ercan , Şener Yağmur 
Published: October 2019

ABSTRACTOdontomas generally appear as small, solitary or multiple radio-opaque lesions found on routine radiographic examinations. Traditionally, odontomas have been classified as benign odontogenic tumors and are subdivided into complex or compound odontomas morphologically. Compound odontomas commonly occur in the incisor-canine region of the maxilla and complex odontomas are frequently located in the premolar and molar region of both jaws. Occasionally, odontoma may cause disturbances in the eruption of teeth such as impaction, delay eruption or retention of primary teeth. In general, odontomas occur more often in the permanent dentition and are very rarely associated with the primary teeth. In this report; two cases of compound odontoma associated with primary teeth is presented. (Eur J Dent 2007;1:45-49)
A Different Pontic Design for Fiber-Reinforced Composite Bridgeworks: A Clinical Report
Authors: Kumbuloğlua Ovul , Özdemira Niler , Aksoy Gökhan , User Atilla 
Published: October 2019

ABSTRACTThis clinical report describes a relatively simple but esthetic, non-invasive and functional prosthodontic treatment option for a patient with missing tooth..Methods: Methods: A patient with a missing maxillary left canine was non-invasively treated with a fiber reinforced composite (FRC) bridgework with an all ceramic (Empress II, Ivoclar Vivadent, Schaan, Liechtenstein) pontic design, using laboratory technique.Results: The restoration has served the patient for 2 year, seemingly without discomfort, and it has not required any maintenance. The patient has kept up with his oral hygiene. Conclusions: Although additional clinical experience is necessary, fiber-reinforced composite materials can be used in combination with a lithium disilicate ceramic material in fixed partial dentures. (Eur J Dent 2007,1:50-53)
Bonded Orthodontic Retainer and Fixed Partial Denture Made with Fiber Reinforced Composite Resin
Authors: Kumbuloglu Ovul , Saracoglu Ahmet , Cura Cenk , User Atilla 
Published: October 2019

ABSTRACTRetention is the phase of orthodontic treatment which maintains teeth in their orthodontically corrected positions, following the cessation of active orthodontic tooth movement. Development of resin-impregnated, fiber-reinforced composite materials has provided the potential to develop new approaches for stabilizing teeth and replacing teeth conservatively. This case report describes the rehabilitation of a patient with orthodontic and prosthetic problems. The long-term behavior of glass fibers splint must be evaluated in clinical studies. (Eur J Dent 2011;5:237-240)
Oral Manifestations in HIV/AIDSInfected Children
Authors: Rwenyonyi Charles Mugisha , Kutesa Annet , Muwazi Louis , Okullo Isaac , Kasangaki Arabat , Kekitinwa Addy 
Published: October 2019

ABSTRACTObjectives: To assess factors influencing the distribution of oral manifestations in HIV/AIDS-infected children attending the Paediatric Infectious Disease Clinic in Mulago Hospital, Kampala. Methods: This was a cross-sectional study comprising 237 children (males/females: 113/124) aged 1 to 12 years. The parents/guardians were interviewed to obtain demographic information, oral hygiene practices, dietary habits and health seeking behaviours as well as any medications taken. The children were clinically examined for oral lesions based on World Health Organization criteria with modifications. Results: About 71.7% of the children cleaned their teeth. About 16.9% of the children had visited a dentist since birth, mainly for emergency care. One or more oral lesions were recorded in 73% of the children of whom 19.0% experienced discomfort during oral functions. Cervical lymphadenopathy, oral candidiasis and gingivitis were the most common soft tissue oral lesions: 60.8%, 28.3% and 19.0%, respectively. Except for dental caries, the overall frequency distribution of soft tissue oral lesions was significantly lower in children on highly active antiretroviral therapy (HAART) as compared to their counterparts not on HAART. The prevalence of dental caries in deciduous and permanent dentitions was 42.2% and 11.0%, respectively. Tooth brushing and previous visits to the dentist were indirectly and significantly associated with dental caries. About 5.9% (n=14) of the children had <200 CD3 + CD4 T-lymphocyte cells per μl of blood. Conclusions: The majority of the children had one or more oral lesions, particularly in the group not on HAART. Some of the lesions were associated with discomfort during oral functions. (Eur J Dent 2011;5:291-298)
Effect of Provisional Cements on Shear Bond Strength of Porcelain Laminate Veneers
Authors: Altintas Subutay Han , Tak Onjen , Secilmis Asli , Usumez Aslihan 
Published: October 2019

ABSTRACTObjectives: The purpose of this study was to evaluate the effect of three provisional cements and two cleaning techniques on the final bond strength of porcelain laminate veneers. Methods: The occlusal third of the crowns of forty molar teeth were sectioned and embedded in autopolymerizing acrylic resin. Dentin surfaces were polished and specimens were randomly divided into four groups (n=10). Provisional restorations were fabricated and two provisional restorations were cemented onto each tooth. Restorations were fixed with one of three different provisional cements: eugenol-free provisional cement (Cavex), calcium hydroxide (Dycal), and light-cured provisional cement (Tempond Clear). Provisional restorations were removed with either a dental explorer and air-water spray, or a cleaning bur (Opticlean). In the control group, provisional restorations were not used on the surfaces of specimens. IPS Empress 2 ceramic discs were luted with a dual-cured resin cement (Panavia F). Shear bond strength was measured using a universal testing machine. Data were statistically analyzed by ANOVA, Tukey’s HSD and Dunnett tests. Surfaces were examined by scanning electronic microscopy. Results: Significant differences were found between the control group and both the light-cured provisional cement groups and the eugenol-free provisional cement-cleaning bur group (P<.05). Groups that had received light-cured provisional cement showed the lowest bond strength values. Conclusions: Selection of the provisional cement is an important factor in the ultimate bond strength of the final restoration. Calcium hydroxide provisional cement and cleaning with a dental explorer are advisable. (Eur J Dent 2011;5:373-379)
The distribution of singular points of the sum of a series of exponential monomials on the boundary of its domain of convergence
Authors: Krivosheev A. S. , Krivosheeva O. A. 
Published: October 2019

Abstract
The problem of the distribution of the singular points of the sum of a series of exponential monomials on the boundary of the domain of convergence of the series is considered. Sufficient conditions are found for a singular point to exist on a prescribed arc on the boundary; these are stated in purely geometric terms. The singular point exists due to simple relations between the maximum density of the exponents of the series in an angle and the length of the arc on the boundary of the domain of convergence that corresponds to this angle. Necessary conditions for a singular point to exist on a prescribed arc on the boundary are also obtained. They are stated in terms of the minimum density of the exponents in an angle and the length of the arc. On this basis, for sequences with density, criteria are established for the existence of a singular point on a prescribed arc on the boundary of the domain of convergence.
Bibliography: 27 titles.
Some arithmetic properties of the values of entire functions of finite order and their first derivatives
Authors: Yanchenko A. Ya. 
Published: October 2019

Abstract
We describe a class of entire functions of finite order which, together with their first derivative, take sufficiently many algebraic values (with certain restrictions on the growth of the degree and height of these values). We show that, under certain conditions, any such function is a rational function of special form of an exponential. For entire functions of finite order which are not representable in the form of a finite linear combination of exponentials, we obtain an estimate for the number of points (in any fixed disc) at which the values of the function itself and its first derivative are algebraic numbers of bounded degree and height.
Bibliography: 8 titles.
The action of the Monge-Ampère operator on polynomials in the plane and its fixed points of polynomial type
Authors: Aminov Yu. A. 
Published: October 2019

Abstract
The action of the Monge-Ampère operator on polynomials of degree four in two variables is investigated. Two necessary conditions for the Monge-Ampère equation to have a solution are established. Sufficient conditions for solvability are indicated, which coincide with necessary conditions in certain cases. Invariant submanifolds of the action of the Monge-Ampère operator are found. Closed invariant chains of polynomials are constructed, and all the fixed points having the form of general polynomials of degree four are found.
Bibliography: 9 titles.
Universality of

-Dirichlet functions and nontrivial zeros of the Riemann zeta-function
Authors: Laurinčikas A. , Petuškinaitė J. 
Published: October 2019

Abstract
We prove a joint discrete universality theorem for Dirichlet

-functions concerning joint approximation of a tuple of analytic functions by shifts

, where

is the sequence of imaginary parts of the nontrivial zeros of the Riemann zeta-function,

is a fixed positive number, and

are pairwise nonequivalent Dirichlet characters. We use a weak form of Montgomery’s conjecture on the correlation of pairs of zeros of the Riemann zeta-function in the analysis. Moreover, we show the universality of certain compositions of Dirichlet

-functions with operators in the space of analytic functions.
Bibliography: 31 titles.
The boundary values of solutions of an elliptic equation
Authors: Gushchin A. K. 
Published: October 2019

Abstract
The paper is devoted to the study of the boundary behaviour of solutions of a second-order elliptic equation. Criteria are established for the existence of a boundary value of a solution of the homogeneous equation under the same conditions on the coefficients of the equation as were used to establish that the Dirichlet problem with a boundary function in

,

, has a unique solution. In particular, an analogue of Riesz’s well-known theorem (on the boundary values of an analytic function) is proved: if a family of norms in the space

of the traces of a solution on surfaces ‘parallel’ to the boundary is bounded, then this family of traces converges in

. This means that the solution of the equation under consideration is a solution of the Dirichlet problem with a certain boundary value in

. Estimates of the nontangential maximal function and of an analogue of the Luzin area integral hold for such a solution, which make it possible to claim that the boundary value is taken in a substantially stronger sense.	Bibliography: 57 titles.
First integrals and asymptotic trajectories
Authors: Kozlov V. V. 
Published: October 2019

Abstract
We discuss the relationship between the singular points of an autonomous system of differential equations and the critical points of its first integrals. Applying the well-known Splitting Lemma, we introduce local coordinates in which the first integral takes a “canonical” form. These coordinates make it possible to introduce a quasihomogeneous structure in some neighbourhood of any singular point and so to prove general theorems on the existence of asymptotic trajectories which go into or out of that singular point. We consider quasihomogeneous truncations of the original system of differential equations and show that if the singular point is isolated, the quasihomogeneous system is Hamiltonian. For a general mechanical system with two degrees of freedom, we prove a theorem on the instability of an equilibrium when it is neither a local minimum nor a local maximum of the potential energy.
Bibliography: 21 titles.
The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells
Authors: McEwen Lisa M. , O’Donnell Kieran J. , McGill Megan G. , Edgar Rachel D. , Jones Meaghan J. , MacIsaac Julia L. , Lin David Tse Shen , Ramadori Katia , Morin Alexander , Gladish Nicole , Garg Elika , Unternaehrer Eva , Pokhvisneva Irina , Karnani Neerja , Kee Michelle Z. L. , Klengel Torsten , Adler Nancy E. , Barr Ronald G. , Letourneau Nicole , Giesbrecht Gerald F. , Reynolds James N. , Czamara Darina , Armstrong Jeffrey M. , Essex Marilyn J. , de Weerth Carolina , Beijers Roseriet , Tollenaar Marieke S. , Bradley Bekh , Jovanovic Tanja , Ressler Kerry J. , Steiner Meir , Entringer Sonja , Wadhwa Pathik D. , Buss Claudia , Bush Nicole R. , Binder Elisabeth B. , Boyce W. Thomas , Meaney Michael J. , Horvath Steve , Kobor Michael S. 
Published: October 2019

Significance
DNA methylation is the most studied modification in human population epigenetics. Its information content can be explored in 2 principal ways—epigenome-wide association studies and epigenetic age. The latter likely reflects cellular/biological age and works with impressive accuracy across most tissues. In adults, it associates with various environments and health. However, current epigenetic clocks are not very accurate in the pediatric age range perhaps because DNA methylation changes much faster in children. Addressing this crucial gap, we created a precise tool to estimate DNA methylation age specific to pediatric buccal epithelial cells. This tool has the potential to become the standard reference for epigenetic studies broadly relevant to child development across the spectrum from health to disease.
Optimized filopodia formation requires myosin tail domain cooperation
Authors: Arthur Ashley L. , Songster Livia D. , Sirkia Helena , Bhattacharya Akash , Kikuti Carlos , Borrega Fernanda Pires , Houdusse Anne , Titus Margaret A. 
Published: October 2019

Significance
Cells interact with their environment using filopodia, thin membrane protrusions supported by actin filaments. Filopodia formation in evolutionarily divergent organisms requires force generation by a MyTH4-FERM (MF) myosin that binds membrane proteins and is designed to promote cytoskeletal reorganization and filopodial transport. The amoeboid filopodial MF myosin is found to be a resilient motor in filopodia formation. Its activity and regulation appear to have emerged by multidomain coevolution for optimized control of filopodia formation and stability. Its properties reflect those of the ancestral MF myosin that gave rise to the metazoan MF myosins. These findings have implications for understanding the fundamental principles of how filopodia form and how MF myosins function in phylogenetically distant organisms.