bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Break Event Point Sebagai Alat Perencanaan Laba Pada PT. Perkebunan Nusantara V Pekanbaru
Authors: Septiarni Ihzaty , Ruzikna Ruzikna 
Published: December 2024

Tujuan penelitian ini adalah untuk mengetahui bagaimana perhitungan break even point dalam perencanaan laba serta bagaimana tingkat Margin of Safety. Jenis penelitian ini adalah penelitian deskriptif pendekatan kuantitatif. Jenis data yang digunakan adalah data sekunder berupa laporan keuangan yang didapatkan dari PT. Perkebunan Nusantara V Pekanbaru. Hasil penelitian Menunjukkan bahwa perusahaan (1) pada kondisi break event point di tahun 2018 yaitu Rp1.439.575.914.520. Break Event Point pada tahun 2019 yaitu Rp1.795.921.314.272. Break event point pada tahun 2020 Rp1.873.578.437.670. BEP pada tahun 2021 Rp2.135.254.142.662 dan break even point pada tahun 2022 Rp2.149.133.893.700 ini menunjukkan bahwa perusahaan dapat mencukupi semua biaya-biaya dan perusahaan mengalami keuntungan dari tahun 2018-2022 (2) namun untuk komoditi karet tidak dapat di katakan BEP pada perusahaan karena dilihat dari BEP untuk komoditi karet sendiri biaya produksi yang dikeluarkan lebih besar dari pendapatan karet sehingga pendapatan tidak dapat menutupi biaya tersebut, hal ini di pengaruhi oleh biaya varibel, harga jual yang meningkat (3) pada tahun 2023 dengan pengestimasian laba sebesar 5% dari laba tahun 2023 agar perusahaan tidak mengalami kerugian maka penjualan yang harus dilakukan sebesar Rp.13.814.057.502.305
دراسة مقارنة بين الإشراف الاكلينيكي التربوي وأشراف الزمالة في احدى مدارس نطاق 1.2 برأس الخيمة من وجهة نظر موظفيها
Authors: عبير عبدالله محمد الطنيجي  
Published: December 2024

يهدف البحث إلى دراسة مقارنة بين الإشراف الاكلينيكي التربوي وأشراف الزمالة في احدى مدارس نطاق 1.2برأس الخيمة من وجهة نظر موظفيها، وقد اعتمدت الباحثة على المنهج الكمي ،وكانت الاستبانة الالكترونية هي الأداة لجمع البيانات ، وتم اختيار عينة قصدية مكونة من (50) من الكادر المدرسي (معلمين وإداريين)،كما تم تحليل البيانات باستخدام البرنامج الإحصائي SPSS ؛ حيث توصلت الدراسة إلى عدة نتائج :المدرسة تفضل نمط الاشراف الاكلينيكي أكثر من إشراف الزمالة ، كذلك عدم وجود فروق ذات دلالة إحصائية عند مستوى دلالة 0.05 بين متوسطي درجات المعلمات في الاشراف الاكلينيكي وإشراف الزمالة بصورة عامة، إلا إنّ المتوسطات الحسابية تظهر فروقا طفيفة بين الأسلوبين تميل لصالح الإشراف الاكلينيكي، كذلك عدم وجود فروق ذات دلالة إحصائية عند مستوى الدلالة (0.05) حول ممارسة المدرسة لإشراف الزمالة تعزى إلى جميع متغيرات الدراسة الديموغرافية عدا في بُعد التقويم والتغذية الراجعة تبعا للوظيفة الحالية، وقدمت الباحثة عدة توصيات أهمها : تبني أساليب إشراف تربوية جديدة مرتكزة على جودة أداء المعلمين في الغرف الصفية، دعم الإشراف الإكلينيكي كأسلوب مهني موجه بالكوادر المتخصصة لتدريب المعلمين حول تحسين نقاط الضعف في الأداء المهني وتلافيها، حث مدارس الإمارة على تطبيق أفضل لإشراف الزمالة، لفعاليته في أدوات التقويم الإشرافية وتقديم التغذية الراجعة المباشرة للمعلمين، تعزيز إشراف الزمالة من خلال تعميمه على المدارس، وبيان دوره في تعديل اتجاهات المعلم، وتدريبه على القيادة الصفية وكيفية التفاعل الصفي.
One-dimensional consolidation analysis of layered foundations with continuous drainage boundaries considering soil structure and physical properties
Authors: Feng Jianxue , Dong Xiaoyu , Luo Ruiqi , Wang Long , Wang Liang , Mei Guoxiong 
Published: December 2024

IntroductionMany theories of consolidation for soils have been proposed in the past, but most of them have ignored the structural characteristics of clay, yet the natural layered soils are widely distributed around the world.MethodsA theoretical model is established to analyze the one-dimensional consolidation behavior of layered soils, in which a time-dependent drainage boundary and the structural characteristics of the soil are taken into account. Using the integral transform and characteristic function methods, the analytical solution is derived, the effectiveness of which is evaluated against the degradation of solutions and the numerical results calculated using the finite element method.Results and discussionFinally, the influences of interface parameter, soil permeability coefficient and soil compressibility on consolidation behaviors are discussed. Results show that in structured soils, early dissipation of excess pore water pressure and consolidation rates are predominantly influenced by interface parameters, permeability, and volume compression coefficients. Higher values of these parameters accelerate early stages of consolidation, which is especially evident in the upper soil layers. Over time, the distinct effects of interface and permeability coefficients on consolidation diminish. Higher volume compression coefficients, while initially beneficial, eventually slow down the consolidation process, indicating an interaction with the ongoing soil structural changes.
The association between triglyceride-glucose index and neutrophil-lymphocyte ratio and all-cause mortality in the general US population: NHANES 2001–2018
Authors: Wang Yifei , Gu Cheng , Chen Bingbing , Qiu Binxu , Yu Jinhai 
Published: December 2024

BackgroundThe association between the triglyceride-glucose (TyG) index and mortality in the general population remains controversial, with inconsistent findings across studies.ObjectiveThis study aims to investigate the relationship between the TyG index and mortality in the U.S. Additionally, it explores whether a new index, combining the TyG index with the neutrophil-to-lymphocyte ratio (NLR), improves the prediction of all-cause compared to the TyG index alone.MethodsSystemic inflammatory markers and the TyG index were calculated based on participants’ complete blood counts and fasting triglyceride and glucose levels. The TyG-NLR index was derived by multiplying the TyG index by the NLR. A weighted Cox proportional hazards model was used to evaluate the associations of the TyG and TyG-NLR indices with mortality risk in the general population. Restricted cubic splines (RCS) were applied to explore and visualize the dose-response relationships between the indices and mortality.ResultThis study included 15388 participants. During a median follow-up of 118 months, 2,333 participants died. After adjusting for potential confounders, no significant association was found between the TyG index and mortality. However, compared to the lowest quartile, participants in the highest quartile of the TyG-NLR index showed a significant association with all-cause mortality. Specifically, those in the highest quartile had a 63% higher risk of all-cause mortality.
Development and validation of a novel immune-related prognostic model and the potential metastatic mechanism in synovial sarcoma
Authors: Huang Yufeng , Gong Ming , Lin Jiaming , Tang Qinglian , Chen Hongmin , Hu Jinxin , Deng Chuangzhong , Huang Anfei , Feng Huixiong , Song Guohui , Xu Huaiyuan , Lu Jinchang , Zhu Xiaojun , Wang Jin 
Published: December 2024

BackgroundSeveral clinical trials have shown that immunotherapy plays a pivotal role in the treatment of patients with metastatic synovial sarcoma. Immune-related genes (IRGs) have been demonstrated to predict the immunotherapy response in certain malignant tumours. However, the clinical significance of IRGs in patients with synovial sarcoma (SS) is still unclear.MethodsWe first combined the immune-related ImmPort gene set to search for SS related to metastatic and differentially expressed immune-related genes (DEIRGs) in the GSE40021 dataset from the GEO database. The soft tissue sarcoma database in TCGA was used for univariate Cox regression analyses to identify DEIRGs that were related to overall survival and to build an immune-related prognostic assessment model.ResultsThe study screened a total of six DEIRGs that were closely related to prognosis in metastatic SS. Further analysis showed that there was no significant difference in the expression of several immune checkpoints between the two groups in the GSE40021 data. Moreover, the GREM2 and CTSS genes were significantly expressed in metastatic patients. Further verification of clinical SS tissues from our centre by RT-qPCR analysis demonstrated reduced infiltration of activated NK cells and macrophages but increased M2-type macrophages in metastatic patients. Together, our study successfully constructed an immune-related prognostic assessment model and probably explains the poor efficacy of PD-1 inhibitors for SS patients.ConclusionThe research deepens our understanding of the tumor immune microenvironment and proposes a new immune mechanism for metastatic SS. Early intervention and reversal of immunosuppressive microenvironmental changes are expected to delay metastasis and improve survival.
Immune regulatory adjuvant approach to mitigate subcutaneous immunogenicity of monoclonal antibodies
Authors: Jarvi Nicole L. , Patel Manali , Shetty Krithika A. , Nguyen Nhan H. , Grasperge Brooke F. , Mager Donald E. , Straubinger Robert M. , Balu-Iyer Sathy V. 
Published: December 2024

IntroductionImmunogenicity continues to be a challenge for development and clinical utility of monoclonal antibodies, and there are gaps in our current ability to prevent anti-drug antibody development in a safe and antigen-specific manner.MethodsTo mitigate immunogenicity of monoclonal antibodies administered subcutaneously, O-phospho-L-serine (OPLS)—the head group of the tolerance-inducing phospholipid, phosphatidylserine—was investigated as an immunoregulatory adjuvant.ResultsFormulations of adalimumab, trastuzumab or rituximab with OPLS showed reduction in relative immunogenicity in mice compared to vehicle formulations, indicated by reduced anti-drug antibody development and significant reductions in CD138+ plasma cell differentiation in bone marrow. Titer development toward recombinant human hyaluronidase, a dispersion enhancer that was co-formulated with monoclonal antibodies, was similarly reduced. Subcutaneous administration of adalimumab with OPLS resulted in a two-fold increase in expression of type 1 regulatory (Tr1) T cell subset in the spleen. This is consistent with in vitro studies where co-culturing of dendritic cells primed with ovalbumin in the presence and absence of OPLS and antigen specific T-cells induced expression of Tr1 phenotype on live CD4+ T cells.ConclusionThis adjuvant does not impact immune competence of non-human primates and mice, and repeated administration of the adjuvant does not show renal or hepatic toxicity. Formulation of monoclonal antibodies with the immunoregulatory adjuvant, OPLS, was found to be safe and effective at mitigating immunogenicity.
Integrating machine learning, bioinformatics and experimental verification to identify a novel prognostic marker associated with tumor immune microenvironment in head and neck squamous carcinoma
Authors: Zeng Xiaoxia , Yang Dunhui , Zhang Jin , Li Kang , Wang Xijia , Ma Fang , Liao Xianqin , Wang Zhen , Zeng Xianhai , Zhang Peng 
Published: December 2024

Head and neck squamous carcinoma (HNSC), characterized by a high degree of malignancy, develops in close association with the tumor immune microenvironment (TIME). Therefore, identifying effective targets related to HNSC and TIME is of paramount importance. Here, we employed the ESTIMATE algorithm to compute immune and stromal cell scores for HNSC samples from the TCGA database and identified differentially expressed genes (DEGs) based on these scores. Subsequently, we utilized four machine learning algorithms to identify four key genes: ITM2A, FOXP3, WIPF1, and RSPO1 from DEGs. Through a comprehensive pan-cancer analysis, our study identified aberrant expression of ITM2A across various tumor types, with a significant association with the TIME. Specifically, ITM2A expression was markedly reduced and correlated with poor prognosis in HNSC. Functional enrichment analysis revealed that ITM2A is implicated in multiple immune-related pathways, including immune-infiltrating cells, immune checkpoints, and immunotherapeutic responses. ITM2A expression was observed in various immune cell populations through single-cell analysis. Furthermore, we showed that ITM2A overexpression inhibited the growth of HNSC cells. Our results suggest that ITM2A may be a novel prognostic marker associated with TIME.
Comparative analysis of SDC2 and SEPT9 methylation tests in the early detection of colorectal cancer: a systematic review and meta-analysis
Authors: Zhang Jie , Li Chenhui , An Yu , Wang Bing , Liang Guowei 
Published: December 2024

PurposeThis meta-analysis aimed to evaluate the comparative diagnostic efficacy of Syndecan-2(SDC2) and Septin-9(SEPT9) in the early detection of colorectal cancer (CRC).MethodsWe searched PubMed, Embase, Web of Science, and Cochrane Library databases to identify available publications up to October 2024. A direct head-to-head comparator analysis were performed using the random-effects model. Subgroup analyses and corresponding meta-regressions focusing on sample source, number of patients, region, study design, and methylated detection methods were conducted. Intra-group and inter-group heterogeneity were assessed by Cochrane Q and I2 statistics.ResultsEleven articles involving 1,913 CRC patients and 2,851 healthy people were included in the meta-analysis. The sensitivity of SDC2 was similar compared to SEPT9 for CRC patients (0.67 vs. 0.71, p = 0.61), SDC2 has a similar specificity in comparison to SEPT9 for CRC patients (0.90 vs. 0.91, p = 0.86). In subgroup analysis, stool SDC2 was similar compared to stool SEPT9 for CRC patients (sensitivity of 0.81 vs. 0.80, p = 0.92; specificity of 0.93 vs. 0.91, p = 0.73), plasma SDC2 was similar compared to plasma SEPT9 for CRC patients (sensitivity of 0.57 vs. 0.72, p = 0.27; specificity of 0.90 vs. 0.89, p = 0.89). In the subgroup analysis of clinical staging for colorectal cancer (CRC), the results indicate that there is no significant difference in sensitivity between the two markers for both early (0.7 vs. 0.67, p = 0.64) and advanced (0.76 vs. 0.70, p = 0.23) stages of CRC.ConclusionIn our head-to-head comparison meta-analysis, it was found that SDC2 and SEPT9 have similar sensitivity and specificity in the diagnosis of colorectal cancer. However, this result may be influenced by high heterogeneity and further confirmation of this finding is needed through large-scale prospective studies.
NUP155 and NDC1 interaction in NSCLC: a promising target for tumor progression
Authors: Li Kai-Min , Meng Li-Fei , Yang Zhi-Hao , Hu Wen-Tao 
Published: December 2024

BackgroundNUP155 was reported to involve breast invasive carcinoma and hepatocellular carcinoma. We hypothesized that NUP155 and NDC1impacted the progression of NSCLC.MethodsThe dataset was analyzed to find differentially expressed genes. Functional enrichment analysis and Kaplan-Meier survival analysis were performed for differentially expressed genes. Western blot, Clone formation assay, Transwell assay and CCK-8 assay were performed to determine the performance and role of the target gene in NSCLC.ResultsThe research found that the NUP family played a role in various diseases. Differential expression analysis and survival analysis were performed to identify 6 related-genes, including NUP155, NDC1, KPNA2, MAD2L1, NUP62CL, and POM121L2NUP155 and NDC1 could interact with NUP53, respectively. This effect was necessary to complete the assembly of the nuclear pore complex.ConclusionNUP155 interacted with NDC1 to complete the assembly of the nuclear pore complex, which promoted the development of NSCLC. Our study demonstrated that NUP155 was expected to be a potential target for the treatment of NSCLC.
Case report: Depression in an older patient with dysgeusia as the initial symptom
Authors: Guo Longrun , He Zhufa 
Published: December 2024

IntroductionDepression is the most common mental illness among older adults, with substantial and persistent mood depression as the main clinical feature, which is unfavorable for improvement. The clinical manifestations can range from melancholy to grief or even numbness. Approximately one-third of older adult patients exhibit physical discomfort as the first symptom; dysgeusia as the first symptom, is very rare in clinical practice. Dysgeusia is a clinical symptom with no specific objective indicator; thus, the likelihood of misdiagnosis and missed diagnosis is high.Case presentationIn this study, a 60-year-old female housewife with elementary school as her highest level of education, presented to the outpatient department with dysgeusia, poor sleep, and poor mood persisting for &gt;1 year, which aggravated 2 weeks before hospital visit. Psychiatric examination showed clear consciousness; the patient was cleanly and timely dressed and demonstrated self-care but had a worrisome expression. Using the diagnostic criteria of the International Classification of Diseases (10th edition), a diagnosis of a major depressive episode with psychotic symptoms was made. Following pharmacological and psychological treatment, the patient’s condition improved. The patient was compliant to treatment (10 mg/day of escitalopram), had a stable mood, good sleep, and no dysgeusia at &gt;2 years of follow-up as an outpatient. She was able to do housework and take care of her children normally and did not complain about any other issues.ConclusionPhysical discomfort is a very common complaint in older patients with depression. If persistent physical symptoms do not improve after repeated medical treatment, timely assessment of the patient’s mental state or psychiatric referral should be considered to diagnose geriatric depression. Timely pharmacological and psychological therapy are the preferred treatment for older adults.
Neural correlates of audiovisual integration in schizophrenia – an ERP study
Authors: Borgolte A. , Sinke C. , Michalke L. , Möde L. , Lepsy N. , Wiswede D. , Bleich S. , Szycik G. R. , Ghaneirad E. 
Published: December 2024

IntroductionMultisensory integration (MSI) enhances perception by combining information from different sensory modalities. In schizophrenia, individuals often exhibit impaired audiovisual processing, resulting in broader temporal binding windows (TBWs) which appear to be associated with symptom severity. Since the underlying mechanisms of these aberrations are not yet fully understood, the present study aims to investigate multisensory processing in schizophrenia in more detail.MethodsIndividuals with schizophrenia (SZ) and healthy controls (HC) performed a simultaneity judgement task, a paradigm that is suitable for the examination of multisensory integration processes. The paradigm was also conducted to allow for the comparison of perceptions under ecologically valid and invalid conditions. Additionally, EEG recordings were made to explore underlying neural mechanisms.ResultsIn line with previous research, we replicated enlarged TBWs in SZ compared to HC, independent of ecological validity. Neurophysiological data further revealed reduced amplitudes in the early ERP complex N1/P2 in SZ compared to HC.DiscussionSince amplitude reduction in the N1/P2 complex is often associated with audiovisual integration processes, the results highlight perceptual dysfunction in SZ, particularly concerning the disengagement of auditory and visual stimuli.
Bridging trauma and eating disorders: the role of loneliness
Authors: Meneguzzo Paolo , Marzotto Anna , Mezzani Barbara , Conti Fabio , Maggi Luca , Todisco Patrizia 
Published: December 2024

IntroductionEating disorders (EDs) are complex and often linked to traumatic childhood experiences. While childhood trauma is known to increase the risk of EDs, the role of loneliness remains underexplored. This study investigates whether loneliness mediates the relationship between childhood trauma and ED symptoms.MethodsA total of 230 individuals with EDs completed the Childhood Trauma Questionnaire, the UCLA Loneliness Scale, and the Eating Disorders Examination Questionnaire. Mediation analysis was conducted to assess if loneliness mediates the relationship between childhood trauma and ED severity.ResultsChildhood trauma significantly predicted higher levels of loneliness (p &lt; 0.001), which was associated with more severe ED symptoms (p = 0.001), with age and BMI as covariates. Mediation analysis showed loneliness partially mediated the relationship between childhood trauma and ED severity (indirect effect b = 0.003, 95%CI [0.001, 0.006]).ConclusionLoneliness partially mediates childhood trauma and ED symptoms, highlighting the need to address loneliness in treatment to mitigate the impact of childhood trauma on ED severity. These findings suggest the possible role of social connection-focused interventions in ED care and contribute to understanding the mechanisms underlying the development of EDs. Future research should explore additional mediators and moderators to provide a more comprehensive perspective.
Factors related to sedentary behavior in older adult stroke patients in China: a study based on decision tree and logistic regression model
Authors: Liu Shuxian , Li Juan , Chen Xi , Jiang Xiaowen , Tang Rong , Lv Yumei 
Published: December 2024

ObjectiveThis study investigates the factors influencing sedentary behavior in older adult Chinese stroke patients using decision trees and logistic regression models.MethodsConvenience sampling method was employed to enroll 346 respondents aged ≥60 years with stroke from the Department of Neurology of three tertiary-level A hospitals in Heilongjiang province, based on the inclusion criteria. The Sedentary Behavior Questionnaire for Older Adults, the International Physical Activity Questionnaire Short Form (IPAQ-S), the Pittsburgh Sleep Quality Index (PSQI), the Self-Rating Depression Scale (SDS), and the Social Support Scale (SSRS) were used to assess sedentary behavior, physical activity level, sleep quality, depressive symptoms, and social support, respectively. Decision tree and logistic regression models were employed to analyze the factors related to sedentary behavior in older adult stroke patients.ResultsOf the 346 respondents, 233 (67.3%) had sedentary behavior. The logistic regression model showed that education level (OR = 2.843, 95%CI: 1.219–6.626), BMI (OR = 3.686, 95%CI: 1.838–7.393), longest consecutive sitting time (OR = 3.853, 95%CI: 1.867–7.953), and sleep quality (OR = 3.832, 95%CI: 1.716–8.557) were identified as risk factors for sedentary behavior in older adult stroke patients, while drink alcohol (OR = 0.386, 95%CI: 0.184–0.809) and physical activity level (OR = 0.064, 95%CI: 0.030–0.140) were identified as protective factors for sedentary behavior. Besides, the decision tree model showed that physical activity level, longest consecutive sitting time, sleep quality, BMI, depressive symptoms, and age were associated with sedentary behavior. The sensitivity and specificity of the logistic regression model were 69.9 and 93.1%, respectively, and the area under the receiver operating characteristic (ROC) curve was 0.900 (95% CI: 0.863–0.938). The sensitivity and specificity of the decision tree model were 66.4, and 93.1% respectively, and the area under the ROC curve was 0.860 (95% CI: 0.816–0.904).ConclusionOur findings indicated that physical activity level, longest consecutive sitting time, sleep quality, and BMI were key factors associated with sedentary behavior. To achieve the purpose of improving rehabilitation effect and quality of life, this study combining decision trees with logistic regression models was of high value in studying factors influencing sedentary behavior in older adult stroke patients.