bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Small Cell Lung Cancer Recurrences after Surgical and Combined Modality Treatment with Postoperative Radiation Therapy
Authors: Солодкий В. , Solodkiy V. , Сотников В. , Sotnikov V. , Троценко С. , Trotsenko S. , Харченко В. , Kharchenko V. , Чхиквадзе В. , Chkhikvadze V. , Нуднов Н. , Nudnov N. , Паньшин Г. , Panshin G. , Моргунов А. , Morgunov A. 
Published: December 2018

Purpose: To compare the patterns of the relapses after the surgical and combined modality treatment of non-small cell lung cancer (NSCLC) with the postoperative radiotherapy (PORT).
Material and methods: The comparative evaluation of the patterns of the relapses was carried out in 528 NSCLC patients with the IA–IIIB stage after surgical treatment (n = 174) and combined modality treatment (n = 354) using PORT in the hypofractionation regimen 3 Gy/fraction, 5 times a week, TD 36–39 Gy (EQD2 = 43.2–46.8 Gy, α/β = 3) and classical fractionation 2 Gy/fraction, 5 times a week, TD 44 Gy.
Results: The local and the regional relapses developed from 2 to 59 months after treatment, most often in the first three years of follow-up (median 15 months). The local and the regional relapses were statistically significantly more frequent in the surgical treatment group (31.6 % vs 7.1 %). The frequency of the distant metastases in the both groups was not statistically different (46.6 % vs 42.3 %), however, in the surgical treatment group, the distant metastases were more often combined with the locoregional relapses (18.4 % vs 4.5 %). Surgery+PORT in comparison with surgical treatment alone reduces the incidence of locoregional recurrence at the central location of the tumor (8.8 % vs 40.0 %), peripheral non-small cell lung cancer (5.2 % vs 26.0 %), with squamous histological type of tumor (8.4 % vs 37.5 %) and in adenocarcinoma (4.6 % vs 26.4 %), regardless of the volume of surgical treatment (pneumonectomy – 7.0 % vs 47, 1 %, p = 0.0002, lobectomy and bilobectomy – 7.1 % vs 20.6 %, p = 0.001, segmentectomy – 7.1 % vs 50.0 %, p = 0.0001). In the subgroup of patients undergoing adjuvant chemotherapy and PORT, the local, regional and locoregional relapses were statistically significantly less common than in the group of non-small cell lung cancer patients who received only adjuvant chemotherapy (3.9 % vs 17.5 %, p = 0.002, 5.4 % vs 23.8 %, p = 0.001, 6.2 % vs 36.5 %, p = 0.0001). The number of combined relapses (local and/or regional relapses + distant metastases) was actually four times less in all subgroups of patients with PORT (4.7 % vs 20.6 %, p = 0.001).
Conclusion: PORT as the part of combined treatment of non-small cell lung cancer statistically significantly reduces the incidence of the local, regional, locoregional and combined relapses in the squamous cell lung cancer and adenocarcinoma, central and peripheral localization of the tumor, after surgical treatment in the volume of pneumonectomy, lob-bilobectomy and segmentectomy, and when using with or without adjuvant chemotherapy.
Six weeks' notice of the on-call roster: fact or fantasy? An audit study
Authors: Pepper Thomas , Hicks Georgina 
Published: December 2018

Introduction: Work–life balance is directly linked to morale, job satisfaction and staff retention – all of which are linked to high quality patient care. Receiving the duty roster in advance is the first step towards achieving any work–life balance, but anecdotally doctors frequently receive very little notice of this. This audit assessed NHS trusts' compliance with the Code of Practice, with specific reference to advance notification of duty rosters. Method: The duty roster should be made available 6 weeks before commencement of post. The initial audit comprised a survey sent to all London surgical CT1s starting in October 2016. The interventions introduced following this were creation of a shared spreadsheet containing roster coordinator contact details, reminder emails sent to roster coordinators and distribution of results to NHS Improvement. A repeat survey was sent to all London surgical CT1s and CT2s starting in October 2017. Results: In the initial audit 48/88 (55%) responded, of whom 4/48 (8%) received their duty roster in accordance with the standard and 9/48 (19%) did not receive the roster at all before starting. A total of 40/48 (83%) of trainees had to make specific contact with their future NHS trust in order to obtain their roster. In this initial audit 12/48 (25%) of trainees were satisfied or very satisfied with the amount of notice given. In the reaudit 133/178 (75%) responded, of whom 23/133 (17%) had received their roster in accordance with the standard and 25/133 (19%) did not receive the roster at all before starting. A total of 97/133 (73%) of trainees had to make specific contact with their future NHS trust in order to obtain their roster. In the reaudit 56/133 (42%) of trainees were satisfied or very satisfied with the amount of notice given. Conclusions: This closed loop audit led to a doubling in the proportion of trainees receiving their rosters in accordance with the standard, and this was associated with an increase in trainee satisfaction levels. However, adherence to the standard remained low in both phases of the audit, and a significant proportion of trainees continue to commence jobs without any knowledge of their on-call roster. A range of measures is proposed to address this.
Il saluto finale delle petizioni nei papiri di epoca romana: da εὐτύχει a διευτύχει
Authors: Mascellari Roberto 
Published: December 2018

Abstract
By re-examining several papyrological documents and proposing various corrections, this article establishes that the word εὐτύχει is no longer used as closing farewell in petitions after 117 CE, when διευτύχει takes over.
Brain abnormality detection using template matching
Authors: Praveen G.B. , Agrawal Anita , Pareek Shrey , Prince Amalin 
Published: December 2018

Abstract
Magnetic resonance imaging (MRI) is a widely used imaging modality to evaluate brain disorders. MRI generates huge volumes of data, which consist of a sequence of scans taken at different instances of time. As the presence of brain disorders has to be evaluated on all magnetic resonance (MR) sequences, manual brain disorder detection becomes a tedious process and is prone to inter- and intra-rater errors. A technique for detecting abnormalities in brain MRI using template matching is proposed. Bias filed correction is performed on volumetric scans using N4ITK filter, followed by volumetric registration. Normalized cross-correlation template matching is used for image registration taking into account, the rotation and scaling operations. A template of abnormality is selected which is then matched in the volumetric scans, if found, the corresponding image is retrieved. Post-processing of the retrieved images is performed by the thresholding operation; the coordinates and area of the abnormality are reported. The experiments are carried out on the glioma dataset obtained from Brain Tumor Segmentation Challenge 2013 database (BRATS 2013). Glioma dataset consisted of MR scans of 30 real glioma patients and 50 simulated glioma patients. NVIDIA Compute Unified Device Architecture framework is employed in this paper, and it is found that the detection speed using graphics processing unit is almost four times faster than using only central processing unit. The average Dice and Jaccard coefficients for a wide range of trials are found to be 0.91 and 0.83, respectively.
A brief insight into the prediction of water vapor transmissibility in highly impermeable hybrid nanocomposites based on bromobutyl/epichlorohydrin rubber blends
Authors: Sankaran Kumar , Manoharan Partheban , S Sofana Reka , Chattopadhyay Santanu 
Published: December 2018

AbstractThe present work proposes a schematic model for predicting the water vapor transmissibility in hybrid nanocomposites based on bromobutyl (BIIR)/epichlorohydrin (CO) rubber blends. Morphology study reveals the exfoliation of nanoclay and development of hybrid nanostructures in the rubber nanocomposites. A unique correlation between water vapor transmissibility and gas (oxygen) permeability through the rubber nanocomposites has been systematically derived. The prediction of relative water vapor transmissibility was achieved by considering the polar path along with the existing tortuous path and has been validated. Interestingly, it is found that the water vapor transmissibility (TW) directly depends on the weight fraction of the polar rubber (ΦP) in the rubber blend and permeability to gas (PG) of the nanocomposites.
Sand Dune Characterization for Preparing Metallurgical Grade Silicon
Authors: Boussaa S. Anas , Kheloufi A. , Zaourar N. Boutarek 
Published: December 2018

AbstractDune sand, from Biskra, Algeria which is in the Great Algerian huge desert attracts tourists from all over the world. Dune sand composes around 80% of the total area of the desert. To date only a few studies have been conducted on this sand. The purpose of the present study is to shed light on the textural and physico-chemical characteristics of this sand using several characterization methods, and to understand the potential for using for photovoltaic applications. The chemical composition of Biskra sand indicated a high purity quartz with 97.6% silica, and a presence of others oxides. Granular analysis enabled the determination of the size of the sand grains which was found to be fine to medium. On the other hand, a Scanning Electron Microscopy and optical observations were carried out, the micrographs observations indicated the presence of different shapes of sand grain, some rounded whereas others are angular edged or elongated. X-ray diffraction indicates the highly crystalline nature of the Biskra sand.
Catalytic Applications of Large Pore Sulfonic Acid-Functionalized SBA-15 Mesoporous Silica for Esterification
Authors: Erdem Beyhan , Erdem Sezer , Öksüzoğlu Ramis Mustafa 
Published: December 2018

Abstract
We report the preparation of pore expanded and sulfonic acid functionalized mesoporous silica catalysts by using different kinds of swelling agents such as 1,3,5-trimethyl benzene (TMB), n-decane (D), n-tridecane (TD), and n-hexadecane (HD) at two different ratios of swelling agent/surfactant. Non-swelled mesoporous silica catalyst, SBA-15-SO3H, was also prepared for comparison. The performance of the sulfonic acid functionalized solid acid catalysts by using one-pot synthesis procedure was evaluated in terms of their catalytic activity in the esterification of propionic acid with methanol. The catalysts have been characterized by X-ray diffraction to investigate the phase transition between the hexagonally packed arrangement of cylindrical pores and mesocellular silica foams (MCF), and N2 adsorption/desorption technique in terms of pore size and distributions. It was concluded from the XRD and N2 adsorption/desorption analyses that hexagonally packed and cylindrical pore structure is maintained only for low ratio of swelling agent/surfactant and the increase of the dimension of a template micelle is accompanied by an increase in structural disruption, which was attributed to the phase transition from highly ordered hexagonal arrangement to mesocellular foam (MCF) phase with large nodded pore structures rather than cylindrical pores. Among the different swelling agents, TMB and D were found to be effective for the increase in pore diameter (up to 8 and 7.8 nm), whereas, TD and HD (6.6 nm) are effective to maintain the ordered X-ray diffraction patterns resulting mesoporous materials without giving enlargement of pore diameter in comparison with TMB and D. Pore expanded catalysts, SBA-15-SO3H-TMB-0.1 and SBA-15-SO3H-D-0.1, exhibit 68 and 43% enhancement in turnover frequency toward propionic acid methanol esterification, respectively, over non-swelled SBA-15-SO3H, despite possessing similar acid strengths. The increased activity especially for SBA-15-SO3H-TMB-0.1 and SBA-15-SO3H-D-0.1 likely reflects the accessibility to the active sulfonic acid sites as well as acidity.
Postfixation or inflection inside derivation
Authors: Körtvélyessy Lívia , Štekauer Pavol 
Published: December 2018

AbstractThe paper discusses the widely accepted assumption concerning the postulated universal ordering of derivational and inflectional affixes, first proposed by Greenberg as Universal #28. Various theoretical and empirical predictions underlying this assumption are briefly outlined. A sample of 73 European languages and a sample of 58 ‘world’ languages are used to show the range of violations of Greenberg’s universal in order to propose a tentative typology of these violations, and to examine the relatedness of postfixation to the genetic type of a language and its areal characteristics.
Lignin-based foams as insulation materials: a review
Authors: Mimini Vebi , Kabrelian Vasken , Fackler Karin , Hettegger Hubert , Potthast Antje , Rosenau Thomas 
Published: December 2018

Abstract
The bulk use of renewable polymers is currently largely limited to cellulose and, less significantly, hemicelluloses. Technical lignins are only applied in novel materials to a rather limited extent, although bulk lignin utilization is a worldwide research object. Native lignins, which belong to the second or third most abundant biopolymers of terrestrial plants, are mostly used in the form of technical lignins from wood pulping processes; they are employed in low-performance sectors or simply burnt for the generation of energy. Technical lignins are available in huge quantities and have a large application potential, mainly in areas where their aromatic nature is of relevance. This review presents the state of the art of foamed lignin-based polymers (lignofoams) as high-performance insulation materials. In the focus of this presentation are the fundamental foaming principles and influential agents that have an improvement potential concerning the matrix interactions between technical lignins (including lignosulfonates) and a copolymer in foam composites. The different approaches for foam preparation are critically compared. In general, the reviewed papers disclose that the lignin part in foams should be less than 37%. There are significant difficulties to improve the properties of lignofoams, and thus intensive research is needed to find better formulations and new technologies.
shRNA-Induced Knockdown of a Bioinformatically Predicted Target IL10 Influences Functional Parameters in Spontaneously Hypertensive Rats with Asthma
Authors: Drevytska Tatiana , Morhachov Roman , Tumanovska Lesya , Portnichenko Georgiy , Nagibin Vasyl , Boldyriev Oleksiy , Lapikova-Bryhinska Tatiana , Gurianova Veronika , Dons’koi Borys , Freidin Maxim , Ivanisenko Vladimir , Bragina Elena Yu , Hofestädt Ralf , Dosenko Victor 
Published: December 2018

Abstract
One of the most common comorbid pathology is asthma and arterial hypertension. For experimental modeling of comorbidity we have used spontaneously hypertensive rats with ovalbumin (OVA)-induced asthma. Rats were randomly divided into three groups: control group, OVA-induced asthma group; OVA-induced asthma + IL10 shRNA interference group. Target gene (IL10) was predicted by ANDSystem. We have demonstrated that RNA-interference of IL10 affected cardiovascular (tested using Millar microcatheter system) as well as respiratory functions (tested using force-oscillation technique, Flexivent) in rats. We have shown that during RNA-interference of IL10 gene in vivo there were changes in both cardiac and lung function parameters. These changes in the cardiovascular parameters can be described as positive. But the more intensive heart workload can lead to exhaust and decompensation of the heart functions. Knockdown of IL10 gene in asthma modeling induces some positive changes in respiratory functions of asthmatic animals such as decreased elastance and increased compliance of the lungs, as well as less pronounced pathomorphological changes in the lung tissue. Thus, we provide the data about experimentally confirmed functionality changes of the target which was in silico predicted to be associated with both asthma and hypertension – in our new experimental model of comorbid pathology.
Active optics in astronomy – modeling of deformable substrates: freeform surfaces for FIREBall and MESSIER
Authors: Lemaitre Gérard Rene 
Published: December 2018

Abstract
Active optics techniques on large telescopes and astronomical instrumentations provide high imaging quality. For ground-based astronomy, the co-addition of adaptive optics again increases angular resolution up to providing diffraction-limited imaging at least in the infrared. Active and adaptive optics marked milestone progress in the detection of exoplanets, super-massive black holes, and large-scale structure of galaxies. This paper is dedicated to highly deformable active optics that can generate non-axisymmetric aspheric surfaces – or freeform surfaces – by use of a minimum number of actuators: a single uniform load acts over the surface of a vase-form substrate whilst under reaction to its elliptical perimeter ring. Two such instruments are presented: (1) the Faint Intergalactic Redshifted Emission Balloon (FIREBall) telescope and multi object spectrograph (MOS) where the freeform reflective diffraction grating is generated by replication of a deformable master grating, and (2) the MESSIER wide-field low-central-obstruction three-mirror-anastigmat (TMA) telescope proposal where the freeform mirror is generated by stress figuring and elastic relaxation. Freeform surfaces were obtained by plane super-polishing. Preliminary analysis required use of the optics theory of 3rd-order aberrations and elasticity theory of thin elliptical plates. Final cross-optimizations were carried out with Zemax raytracing code and Nastran FEA elasticity code in order to determine geometry of the deformable substrates.
IUPAC Periodic Table of the Elements and Isotopes (IPTEI) for the Education Community (IUPAC Technical Report)
Authors: Holden Norman E. , Coplen Tyler B. , Böhlke John K. , Tarbox Lauren V. , Benefield Jacqueline , de Laeter John R. , Mahaffy Peter G. , O’Connor Glenda , Roth Etienne , Tepper Dorothy H. , Walczyk Thomas , Wieser Michael E. , Yoneda Shigekazu 
Published: December 2018

AbstractThe IUPAC (International Union of Pure and Applied Chemistry) Periodic Table of the Elements and Isotopes (IPTEI) was created to familiarize students, teachers, and non-professionals with the existence and importance of isotopes of the chemical elements. The IPTEI is modeled on the familiar Periodic Table of the Chemical Elements. The IPTEI is intended to hang on the walls of chemistry laboratories and classrooms. Each cell of the IPTEI provides the chemical name, symbol, atomic number, and standard atomic weight of an element. Color-coded pie charts in each element cell display the stable isotopes and the relatively long-lived radioactive isotopes having characteristic terrestrial isotopic compositions that determine the standard atomic weight of each element. The background color scheme of cells categorizes the 118 elements into four groups: (1) white indicates the element has no standard atomic weight, (2) blue indicates the element has only one isotope that is used to determine its standard atomic weight, which is given as a single value with an uncertainty, (3) yellow indicates the element has two or more isotopes that are used to determine its standard atomic weight, which is given as a single value with an uncertainty, and (4) pink indicates the element has a well-documented variation in its atomic weight, and the standard atomic weight is expressed as an interval. An element-by-element review accompanies the IPTEI and includes a chart of all known stable and radioactive isotopes for each element. Practical applications of isotopic measurements and technologies are included for the following fields: forensic science, geochronology, Earth-system sciences, environmental science, and human health sciences, including medical diagnosis and treatment.
Mütterliche Ursachen in Proklos’ Metaphysik
Authors: Schultz Jana 
Published: December 2018

AbstractIn his commentary on Plato’sParmenidesProclos describes the maternal and paternal contributions to reproduction as of equal value: The paternal seed furnishes potential λόγοι, the mother actualises them and so causes the reversion of the offspring. However, the definition of the mother as actualising cause is linked to the particular circumstances of conception in the sphere of nature. In general, Proclus bases his concept of femininity on the idea of a shared, but not equal activity by paternal and maternal causes. In the metaphysical sphere the maternal cause is distinguished by its inspiring activity, that is, it provokes the procession of powers that are permanently anchored in the father and so it enables the begetting of the offspring as an entity separate from the father. This activity involves a loss of perfection, which is the basis for a difference in value between the activities of the maternal and paternal causes.
Radiation protective characteristics of some selected tungstates
Authors: Sayyed Mohammed I. , Lakshminarayana Gandham , Kaçal Mustafa R. , Akman Ferdi 
Published: December 2018

Abstract
The mass attenuation coefficients (μ/ρ) of calcium tungstate, ammonium tungsten oxide, bismuth tungsten oxide, lithium tungstate, cadmium tungstate, magnesium tungstate, strontium tungsten oxide and sodium dodecatungstophosphate hydrate were measured at 14 photon energies in the energy range of 81–1333 keV using 22Na, 54Mn, 57Co, 60Co, 133Ba and 137Cs radioactive sources. The measured μ/ρ values were compared with those obtained from WinXCOM program and the differences between the experimental and theoretical values were very small. The bismuth tungsten oxide has the highest μ/ρ among the present samples in the studied energy region. From the μ/ρ values, we calculated the half value layer, tenth value layer and mean free path, and the results showed that ammonium tungsten oxide (which has the lowest density) and bismuth tungsten oxide (which has the highest density) possess the highest and lowest values of these three parameters, respectively. Additionally, from the incident and transmitted photon intensities, we calculated the radiation protection efficiency (RPE). The bismuth tungsten oxide was found to have RPE 98.53 % at 81 keV, which has the maximum value among the present samples and this suggested that bismuth tungsten oxide is the best to be chosen as the γ radiation shielding material candidate among the selected samples.
The role of neurovascular unit damage in the occurrence and development of Alzheimer’s disease
Authors: Liu Xin , Hou DeRen , Lin FangBo , Luo Jing , Xie JingWen , Wang Yan , Tian Yi 
Published: December 2018

Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease with progressive cognitive impairment. It is the most common type of senile dementia, accounting for 65%–70% of senile dementia [Alzheimer’s Association (2016). 2016 Alzheimer’s disease facts and figures. Alzheimers Dement. 12, 459–509]. At present, the pathogenesis of AD is still unclear. It is considered that β-amyloid deposition, abnormal phosphorylation of tau protein, and neurofibrillary tangles are the basic pathological changes of AD. However, the role of neurovascular unit damage in the pathogenesis of AD has been attracting more and more attention in recent years. The composition of neurovascular unit and the role of neurovascular unit damage in the occurrence and development of AD were reviewed in this paper.