bluuebunny/crossref_metadata_2025_split huggingface dataset:
ABOUT THE ROLE OF THE PODOCIN PROTEIN IN DYSFUNCTION OF KIDNEYS IN PATIENTS WITH DIABETES MELLITUS TYPE 2
Authors: Ibragimov V. M. , Aliskandiev A. M. , Sarvilina I. V. 
Published: October 2018

THE AIM: to investigate the role of the podocin in the progression of renal dysfunction in diabetic nephropathy (DN) in patients with diabetes mellitus (DM) type 2.PATIENTS AND METHODS.The study was open, controlled with parallel design in patients with DM type 2 and with CKD 1-3a. The duration was 4 years. Standard methods for the assessing of hormonal and metabolic profile of the blood and functional activity of kidneys were performed in patients groups and control group. The primary endpoint is the dynamics of podocinuria in patients on the basis of the ELISA.RESULTS:The study included 119 patients (61 men and 58 women) with Diabetes mellitus type 2. Diabetic nephropathy. CKD 1-3a. Patients were divided into 3 groups: group 1 – 37 patients with CKD Stage 1; group 2 – 47 patients with CKD Stage 2; group 3 – 35 patients with CKD Stage 3a. Control group – persons without DM and kidney injury (n=30). The participation of podocin in renal functional activity regulation (dynamics of mean values and correlations with albumin excretion rate and GFR) and hormonal and metabolic interactions (dynamics of mean values of fasting glycemia, OGTT, Hb1Ac, C-peptide, creatinine, potassium, total cholesterol, LDL-C, atherogenic index and their correlations with podocinuria) was shown in patients with DM type 2 and DN.CONCLUSION: podocinuria interrelations with the indices of kidneys functional activity, hormonal and metabolic profile of the blood helps to detail the molecular mechanism of development of ND in type 2 diabetes. Podocin is promising biomarker of CKD 1-2 stages with type 2 DM.
NATRIURETIC PEPTIDES LEVEL AND THE STATUS OF THE RENIN – ANGIOTENSIN-ALDOSTERONE SYSTEM IN CHRONIC KIDNEY DISEASE IN PATIENTS WITH CONGENITAL MALFORMATIONS OF THE URINARY SYSTEM
Authors: Mambetova A. M. , Inarokova A. M. , Shabalova N. N. , Bizheva D. V. , Mahiyeva A. T. 
Published: October 2018

THE AIM. To determine the concentration of natriuretic peptide in the blood serum in children with congenital malformations of the urinary system (CM US) and to compare with the activity of renin-angiotensin-aldosterone system (RAAS).MATERIALS AND METHODS.119 patients with CM US aged 3 to 18 years were examined. A control group of 10 clinically healthy children. 3 groups were assigned: group I – 55 children with congenital vesicoureteral reflux, and group II – 34 children with congenital hydronephrosis and ureterohydronephrosis, III group – 30 children with other forms of dysembryogenesis of the US. Following indicators were identified by ELISA in the blood: renin, aldosterone, N – terminal propeptide natriuretic hormone (NT-рroВNР). RESULTS.NT-рroВNР, renin and aldosterone hyperproduction were diagnosed in 59,6%, 69,7%, 54.6 % of sick children relatively. Concentrations were higher in all variants of malformations in comparison with the control group. Significant differences were revealed in obstructive species, where arterial hypertension (AH) was diagnosed more often. Patients with AH recorded significantly higher concentrations of NT-proВNР and renin.CONCLUSION.The key point in pathological processes developmentand progression in the cardiovascular system and kidneys is the activation of RAAS. The system of natriuretic factors is important in maintaining the compensated state of patients due to the blockade of RAAS.
EVALUATION OF QUALITY OF LIFE IN HEMODIALYSIS PATIENTS USING THE KDQOL-SFTM QUESTIONNAIRE
Authors: Vasiljeva I. A. , Smirnov A. V. 
Published: October 2018

THE AIM.To assess quality of life (QOL) of hemodialysis (HD) patients using the Kidney Disease Quality of Life Short Form (KDQOL-SFTM) questionnaire including specific for dialysis therapy sections.PATIENTS AND METHODS. The KDQOL-SF questionnaire was administered to 192 HD patients. RESULTS. It was shown that HD patients experienced low satisfaction with the employment – 0,0 [0,0–50,0] (Me[IQR]) on the scale of «work status». A low score on the scale of "burden of kidney disease" was registered – 31,3 [18,8–50,0]. The highest scores were obtained on the scales of «cognitive functioning» 86,9 [66,7–93,3], «quality of social interaction» – 80,0 [66,7–93,3], «social functioning» – 62,5 [50,0–87,5], mental health – 60,8±18,1 (M±SD). Among the most significant stress factors – limited ability to travel and fluid restriction (74% and 66% of patients, respectively). The most bothersome problems were muscle soreness (50% pateients), fatigue (45%), dizziness (44%), itchy skin (41%), shortness of breath (40%), dry skin (34%).CONCLUSION. The KDQOL-SFTM questionnaire which takes about 20 minutes to complete provides important information about the limited opportunities and major concerns of dialysis patients.
EVALUATION OF THE INTERRELATIONS OF BLOOD VCAM-1 LEVEL AND CLINICO-MORPHOLOGICAL CHARACTERISTICS OF CHRONIC GLOMERULONEFRITIS
Authors: Bayaundurova K. M. , Batyushin M. M. , Sarvilina I. V. , Antipova N. V. , Sinel’nik E. A. 
Published: October 2018

Chronic glomerulonephritis is characterized by irreversible progression of the pathological process, which leads to the formation of terminal renal failure significantly impairing the patient's quality of life, leading to internal dysfunction and increasing the risk of premature overall and cardiovascular mortality. Consequently, the search for non-invasive methods for assessing the state of renal tissue, including the detection of proteins involved in renal inflammation, fibrosis, intercellular interaction is currently important.THE AIM: To determine the serum levels of the vascular cell adhesion molecule-1 (VCAM-1) in patients with various forms of chronic glomerulonephritis (CGN) and to clarify its relationship to the development of morphological changes in the renal tissue.PATIENTS AND METHODS: In 80 patients (men and women), with CGN in the acute stage was carried out a detailed clinical and laboratory examination, including determination of serum VCAM-1 by ELISA and performing puncture renal biopsy with the assessment of morphological changes. Statistical analysis of the results was carried out using «Microsoft Office Excel 2010» («Microsoft Corp.», USA) and "STATISTICA 10.0" («StatSoft Inc.», USA).RESULTS. The serum level concentration of VCAM-1 was 719 [643;771] ng/ml. Obtained statistically significant interrelations with enlargement of mesangial space, endothelial growth, capillary walls thickening, mesangial hypercellularity, endothelial hypercellularity, protein casts in tubules, anses capillaries union, fibrose demilunes, podocyte necrosis, hypertrophic remodeling type of resistive type vessels, Ig deposites, IgA deposites, IgG seposites, C3 complement fluorescence, fibrinogen deposites. CONCLUSION: The results of the study demonstrate the important role of VCAM-1 in the development of immunocomplex inflammation in glomerulonephritis. VCAM-1 is a marker of different morphological changes in CGN, and determining the level of VCAM-1 in serum is informative, simple and noninvasive method which provides evaluation of inflammatory process activity, prediction of the risk of morphological changes in the renal tissue structure in patients with CGN.
MOLECULAR ASPECTS OF SARCOPENIA PATHOGENESIS IN CHRONOC KIDNEY DISEASE: INTEGRATED ROLE OF mTOR
Authors: Gasanov M. Z. 
Published: October 2018

In recent decades, the main pathogenetic mechanisms for maintaining muscle mass and strength have been discovered. Most of the scientific papers on the molecular aspects of the pathogenesis of sarcopenia were focused on the Akt-signaling pathway. The subject of the study were people of elderly and senile age, immobilized patients, patients with CKD 1-4 stages, animals. However, recently more attention has been paid to the role of protein – the mammalian target of rapamycin mTOR. It seems to be a key link in the control of muscle mass and is a promising marker in understanding the mechanisms of the pathogenesis of sarcopenia. Its importance in protein metabolism in patients with end stage kidney disease is not studied and requires further research. The presented scientific review contains information on the role of mTOR and its components – mTORC1 and mTORC2 in maintaining muscle mass and strength in a healthy person and in the formation of sarcopenia in patients with CKD. The general aid of mTORC1 complex is regulation of protein production which is necessary for cell growth and differentiation. mTORC2 complex functions are not enough studied. It is established that it plays important role in such biological processes as cytoskeleton organization, intracellular homeostasis maintaining, so it provides cell resistance and cell survivability in negative external and internal impulses. mTOR protein can be considered as promising molecular marker in diagnostics of protein metabolism early disturbances in patients with CKD and also as additory factor of sarcopenia severity assessment.
Comparison of the President Prerogative Rights in Indonesia Constitutions
Authors: Adhayanto Oksep , Irman Irman , Shalihah Fithriatus 
Published: October 2018

Prerogative rights can be interpreted as privileges or privileges, The Indonesian constitutional history that has used several constitutions indirectly has implications for the practice of the use of prerogative rights in Indonesia. This study research on the preogrative rights of the President in the Constitutions of Indonesia. The approach used in this study is normative juridical with the law approach model. It is concluded that the use of prerogative rights has ups and downs influenced by the concept of checks and balances and distribution of power. Therefore, the use of prerogative rights as in the previous constitution is more directed to heavy executives who do not require confirmation to other state institutions, now it has begun to be restricted so the use of the term prerogative privileges is no longer pure as before. Keyword: President, Prerogative Rights, Indonesia Constitution
La responsabilité pénale des mineurs en droit international et en droit congolais : Entre un pragmatisme justifié et un dogmatisme affirmé
Authors: Bameme Bienvenu Wane , Lukoji Ghislain-David Kasongo 
Published: October 2018

En droit international, comme en droit interne congolais, le traitement des personnes âgées de moins de dix-huit ans en matière pénale, interpelle et inquiète. L’interpellation se rapporte particulièrement à la situation de l’enfant accusé d’avoir accompli un acte infractionnel ; et l’inquiétude est suscitée notamment par rapport au traitement de l’enfant prétendant avoir subi un préjudice à la suite de l’infraction. L’étude a d’abord utilisé la méthode exégétique, en recherchant le vrai sens à donner aux dispositions normatives en rapport avec la question sous examen. Elle a recouru ensuite à la méthode comparative, en rapprochant en effet de la réglementation internationale, celle congolaise. S’il est vrai que d’une part, la réflexion a souligné la justification pragmatique du droit international de la responsabilité pénale des mineurs, à travers différents instruments internationaux, régulièrement conclus et justement appliqués ; il n’est pas moins vrai qu’elle a noté d’autre part, l’infirmation purement dogmatique de la responsabilité pénale des mineurs de dix-huit ans en droit de la République démocratique du Congo. Il est à retenir qu’en réalité, le clivage mineur-majeur, cesse d’être celui de responsabilité pénale totale et irresponsabilité pénale absolue ou de capacité-incapacité, pour ainsi laisser place à celui de capacité spéciale-capacité générale.
DISEMINASI TEKNOLOGI PEMBUATAN PAKAN BUATAN ALTERNATIF DENGAN CAMPURAN LIMBAH KANGKUNG AIR, IPOMOEA AQUATICA FORKS UNTUK PEMBUDIDAYA IKAN DI SUMATERA BARAT
Authors: Efrizal Efrizal , Rusnam Rusnam , Syaiful Ferry Lismanto 
Published: October 2018

Kegiatan pengabdian kepada masyarakat ini dilakukan dengan tujuan untuk pemanfaatan limbah kangkung air, Ipomoea aquatica Forks, sebagai salah satu bahan baku (material row) pakan buatan alternatif dan meningkatkan pengetahuan serta keterampilan petani ikan (masyarakat) Kelurahan Koto Tangah dalam bidang usaha pembuatan pakan/pelet ikan di Sumatera Barat. Metoda yang digunakan dalam kegiatan ini adalah (1) Penyuluhan (ceramah), dan (2) Peragaan pembuatan tepung dari limbah kangkung air dan pembuatan pelet/pakan ikan alternatif dengan campuran tepung kangkung air. Dari hasil kegiatan pengabdian yang telah dilakukan maka dapat diambil beberapa kesimpulan sebagai berikut:Pengetahuan dan keterampilan kelompok tani sawah laweh dan kelompok tani ikan batang kandis jaya di Desa Sungai Bangek, Kelurahan Balai Gadang, Kec. Koto Tangah Padang sebelum dilaksanakan kegiatan pengabdian IbM ini masih sangat rendah. Namun demikian motivasi atau keinginan masyarakat kelompok tani mitra IbM untuk melakukan usaha budidaya atau pemeliharaan ikan sangat besar. Hal ini dapat dilihat dari keinginan masyarakat kelompok tani mitra IbM untuk menguasai teknologi pembuatan pakan ikan dari hasil limbah kangkung air sangat tingg. Lebih jauh dari kegiatan pengabdian pada masyarakat ini dapat menambah pengetahuan dan keterampilan masyarakat dalam mencari pakan alternatif untuk pakan ikan sehingga kegiatan budidaya dapat berjalan dengan baik di kedua daerah mitra.
FAKTOR-FAKTOR PENENTU KEPUTUSAN PEMBELIAN MELALUI E-COMMERCE PAD PT. GRE
Authors: Yuniarty Yuniarty , Abbas Bahtiar S. 
Published: October 2018

This study aimed to determine the factors that influence purchasing decisions through e-commerce on PT. GRE. The reasearch was conducted to determine whether there is influence of information quality, company reputation, appearance of the site, the benefits received from online shopping, trust, experience shopping through e-commerce, and demographic characteristics to the purchasing decisions through e-commerce. This study took a sample of 96 customers of package tours at PT. GRE that ever make transactions through e-commerce site at least one time. The method of analysis used to test the influencing is binary logistic regression after tested the validity and reliability and confirmatory factor analysis. The results showed that the information quality, the reputation of the company, the benefit received from online shopping, trust, and experience shopping through e-commerce, has a significant influence on the decision to buy through e-commerce at PT. GRE. PT. GRE as the e-commerce businesses are expected to pay more attention to these factors in attracting more customers to make purchases through the e-commerce. Information quality is the factor that most influences buying decisions through e-commerce at PT. GRE and appearance of the site, age, and gender had no significant influence on purchase decisions through e-commerce. PT. GRE can also focus on improving the quality of information in the website.
Keywords—Purchase Decision; E-commerce; Binary Logistic Regression
Abstrak
Penelitian ini bertujuan menentukan faktor yang berpengaruh terhadap keputusan pembelian melalui ecommerce pada PT. GRE. Pengujian dilakukan untuk mengetahui ada tidaknya pengaruh kualitas informasi, reputasi perusahaan, tampilan situs, keuntungan yang diterima dari belanja online, kepercayaan, pengalaman belanja melalui e-commerce, dan karakteristik demografi terhadap keputusan membeli melalui e-commerce. Penelitian ini mengambil sampel sebanyak 96 pelanggan paket tur PT. GRE yang setidaknya satu kali pernah melakukan transaksi melalui situs e-commerce. Metode analisis yang digunakan untuk menguji pengaruh ini adalah regresi logistik binari. Hasil penelitian menunjukkan bahwa kualitas informasi, reputasi perusahaan, keuntungan yang diterima dari belanja online, kepercayaan, dan pengalaman belanja melalui e-commerce, berpengaruh signifikan terhadap keputusan membeli melalui e-commerce PT. GRE. PT. GRE sebagai pelakuecommerce diharapkan untuk lebih memperhatikan faktor-faktor tersebut dalam menarik lebih banyak pelanggan untuk melakukan pembelian melalui e-commerce. Kualitas informasi merupakan faktor yang paling mempengaruhi keputusan membeli melalui e-commerce pada PT. GRE dan tampilan situs, usia, dan genderberpengaruh tidak signifikan pada keputusan membeli melalui e-commerce. PT. GRE juga dapat menfokuskan peningkatan kualitas informasi dalam website.
Kata kunci—Keputusan Pembelian; E-commerce; Regresi Logistik Binari
Yazı Çemberi Tekniğinin Öğretmen Adaylarının Yaratıcı Düşünme Becerilerine Etkisi
Authors: KOÇ AKRAN Sevda , AŞİROĞLU Sevim 
Published: October 2018

Amaç: Bu
araştırmanın temel amacı, yazı çemberi tekniğinin öğretmen adaylarının yaratıcı
düşünme becerilerine etkisini belirlemektir. Yöntem: Araştırmanın
çalışma grubunu, Siirt Üniversitesi, Eğitim fakültesi Sosyal Bilimler ve Türkçe
Eğitiminin Türkçe Öğretmenliği bölümünün 2.sınıfında öğrenim gören 42 deney
grubu, 40 kontrol grubundan toplam 82 öğretmen adayı oluşturmaktadır.
Araştırmada veri toplama aracı olarak Akay’ın (2006) “yaratıcı düşünme ölçeği”
ve araştırmacılar tarafından geliştirilen “yarı yapılandırılmış görüşme formu”
kullanılmıştır. Karma yöntemin kullanıldığı araştırmanın nicel verileri
“yaratıcı düşünme ölçeğinden” nitel veriler ise yarı yapılandırılmış görüşme
formu ve öğrenci günlüklerinden elde edilmiştir. Araştırmada ayrıca doküman
incelemesi yoluyla veriler toplanmıştır. Verilerin analizinde, öğretmen adaylarının yaratıcılık düzeylerini
belirlemek için frekans (f) ve yüzde (%) hesaplamaları; yaratıcılık puanlarının
normal dağılım göstermemesi sonucu Mann Whitney-U testi; yazı çemberinin
öğrenme-öğretme sürecine katkısına yönelik betimsel analiz ve yazı çemberinin
etkililiğine yönelikte betimsel ve içerik analiz yöntemi kullanılmıştır. Bulgular: Araştırma
bulgularına göre, yazı çemberi tekniği ile yapılan etkinlikler deney grubu
öğrencilerinin yaratıcı beceri düzeylerine önemli katkılar sağladığı, onlarda
üst düzey beceriler geliştirdiği söylenebilir. Kontrol grubu öğrencilerinin ise
yaratıcı düşünme becerilerinin orta düzeyde olduğu şeklinde yorumlanabilir.

Sonuçlar ve Öneriler: Araştırma
sonucunda öğrencilerde daha çok eleştirel, yaratıcı düşünme becerisi gelişmiş,
karalama aşamasında bir takım problemlerle karşılaşmışlar ve bu problemleri
farklı yöntem –teknikler kullanarak çözmeye çalışmışlardır. Elde edilen
sonuçlar doğrultusunda öneriler sunulmuştur.
Morphometric characteristics of free‐ranging Eurasian lynx Lynx lynx in Switzerland and their suitability for age estimation
Authors: Marti Iris , Ryser‐Degiorgis Marie‐Pierre 
Published: October 2018

Knowledge of the age of individual animals is crucial to assess population dynamics, disease epidemiology and to successfully implement conservation strategies. Morphometric data reflect complex interactions of factors such as age and sex, and may also depend on genetics, population density, food availability, pathogen load and climate. The aims of this study were to assess the suitability of morphometric characteristics as an ageing tool for lynx during their growth period and to provide baseline data for the Eurasian lynx populations in Switzerland. Seventeen body measurements of 180 free‐ranging Eurasian lynx Lynx lynx of known age, captured or found dead in Switzerland between 1981–2017 were compiled by sex and age class (juveniles, subadults, adults) and tested for significant differences between males and females, age classes, and populations (Jura Mountains, Alps). Classification tree analysis (CART) was performed to create an ageing tool based on physical characteristics. Generalised linear models revealed a significant effect of age and sex on measurements but no differences were found between populations. The growth pattern was characterised by a rapid increase of all parameters in the first year of life, followed by a slowdown in the subadult age class; the adult class corresponded to the post‐growth period. Sex differences became apparent at the age of 9–11 months and were most pronounced in adults. The developed classification trees allowed us to correctly categorise 93% of the females and 92% of the males as juvenile, subadult or adult. In conclusion, classification trees based on body measurements can be used to place lynx into broad age categories and represent a standardised, non‐invasive, fast, cost‐free and very user‐friendly tool. These trees can be successfully combined with tooth wear evaluation and deliver age information with an accuracy acceptable in the context of various epidemiological investigations and of the selection of individuals for translocation.
STRATEGI BERBASIS MAQASHID SYARIAH DALAM MENINGKATKAN DAYA SAING LEMBAGA KEUANGAN MIKRO SYARIAH DI JAMBI
Authors: Djaafar Sucipto 
Published: October 2018

Strategi yang berbasis pada maqashid syariah sangat jarang ditemukan, namun ia merupakan prinsip dasar bagi pengembangan murni lembaga keuangan yang berbasis pada syariah dan bertujuan untuk mencapai falah dan maslahah. Tulisan ini dimaksuksudkan untuk mengkaji strategi untuk meningkatkan daya saing lemabag keuangan syaraih di Provinsi Jambi yang didasarkan kepada strategi berbasis maqashid syariah. Tulisan ini menjelaskan bahwa kinerja Lembaga Keuangan Mikro Syariah di Kota Jambi memiliki tingkat efisiensi yang berbeda-beda bahwa, untuk mensiasati demi meningkatnya daya saing lembga keuangan syaraih agar di[perkuat pada aspek modal sosial berbasis maqashid syariah. Modal sosial Islam dapat dibentuk dari kepercayaan antara lembaga dengan nasabah, dan menjadi intrumen dari aksi yang bertalian dengan lembaga dalam setiap agen sosial konomi, nilai ukhuwah dan solidaritas dapat ditanamkan pada nasabah dan lemabaga keuangan syariah agar dapat memahami prinsip yang lebih baik dari pembagian resiko sebagai ganti dari hanya hutang nasabah dalam keikutsertaan liabilitas hutang pada kasus lemabaga keuangan konvensional