bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viabilidad del uso del videojuego en el aula: opiniones prácticas de los maestros en pre-servicio
Authors: Morales Díaz Marina 
Published: August 2018

RESUMENIncluir videojuegos en el aula de educación primaria se considera un aspecto muy importante para el pleno desarrollo del alumno a nivel cognitivo, por otro lado el desarrollo de las Tecnologías de la Información y de la Comunicación (TIC) esta provocando que hoy en día cada vez más alumnos se interesen por el mundo tecnológico y esto a su vez en los videojuegos.Es por ello, que si nos centramos en el Aprendizaje basado en juegos (AbJ) es un metodología innovadora que aprovecha el potencial educativo que presentan los videojuegos, serious games o recursos lúdicos digitales para impulsar los procesos formativos, favoreciendo que los alumnos adquieran un aprendizaje de forma motivadora, (Del Moral Pérez, Fernández García, y Guzmán-Duque. 2016).En este caso se va a dar a conocer la experiencia en torno a la inclusión de los videojuegos en el Grado de Educación Primaria del Centro de Magisterio “Sagrado Corazón” adscrito a la Universidad de Córdoba, donde se ha involucrado a 35 estudiantes, y los cuales se ha evaluado a través de la observación y un registro cualitativo, donde cada alumno ha arrogado su experiencia en torno a la utilización de los videojuegos dentro del aula. ABSTRACTIncluding videogames in the primary education classroom is considered a very important aspect for the full development of the student at the cognitive level, on the other hand the development of Information and Communication Technologies (ICT) is causing that nowadays every time more students are interested in the technological world and this in turn in video games.That is why, if we focus on learning based on games (AbJ) is an innovative methodology that takes advantage of the educational potential of video games, serious games or digital leisure resources to promote training processes, encouraging students to acquire learning In a motivating way, (Del Moral Pérez, Fernández García, y Guzmán-Duque. 2016).In this case, the experience about the inclusion of videogames in the Primary Education Degree of the Teaching Center "Sacred Heart" assigned to the University of Córdoba, where 35 students have been involved, will be made known. which has been evaluated through observation and a qualitative record, where each student has shared their experience about the use of video games in the classroom.
Environmental impact assessment for a meat processing industry in Turkey: wastewater treatment plant
Authors: Yapıcıoğlu Pelin Soyertaş 
Published: August 2018

Abstract
The meat processing industry has many unfavorable impacts to the environment in Turkey. One of these impacts is wastewater treatment. Meat processing wastewater contains large amounts of proteins, fats, nutrients such as nitrogen, and pathogenic and non-pathogenic microorganisms and viruses. The high organic and hazardous content of wastewater causes environmental challenges for the flora and fauna in receiving water bodies unless it is treated adequately. Due to these reasons, the treatment process to be implemented should be the least damaging to the environment. In this study, three treatment scenarios that include a UASB (upflow anaerobic sludge bed) reactor (Scenario-1), an advanced oxidation process that includes UV/H2O2 treatment (Scenario-2) and a membrane bioreactor (Scenario-3) have been studied for a meat processor's wastewater treatment plant. For these three scenarios, an environmental impact assessment was undertaken using the Fine-Kinney method. The evaluation results revealed that Scenario-2 has the smallest environmental impact value with 475. Scenario-1 has the highest total environmental impact value as 765. Scenario-3's environmental impact value is 637. According to the evaluation results, the UV/H2O2 process is the most applicable technology for wastewater treatment in Turkey's meat industry.
Plant-wide modelling for assessment and optimization of upgraded full-scale wastewater treatment plant performance
Authors: Hvala Nadja , Vrečko Darko , Bordon Cirila 
Published: August 2018

Abstract
This paper presents the design of a plant-wide CNP (carbon-nitrogen-phosphorus) simulation model of a full-scale wastewater treatment plant, which will be upgraded for tertiary treatment to achieve compliance with effluent total nitrogen (TN) and total phosphorus (TP) limit values. The plant-wide model of the existing plant was first designed and extensively validated under long-term dynamic operation. The most crucial step was a precise characterization of input wastewater that was performed by extending the plant performance indicators both to a water line and sludge line and systematically estimating identifiable wastewater characterization parameters from plant-wide performance indicators, i.e. effluent concentrations, biogas and sludge production, and sludge composition. The thus constructed simulation model with standard activated sludge model (ASM2d) and anaerobic digestion model (MantisAD) overpredicted ortho-P and ammonia-N on the sludge line, indicating a need to integrate state-of-the-art physico-chemical minerals precipitation models to simulate plant-wide interactions more precisely. The upgraded plant with multimode anaerobic/anoxic/oxic configuration shows limited denitrification potential. Therefore, additional reject water treatment was evaluated to improve effluent TN and TP performance.
Energy–water and GHG nexus: A South African water industry case
Authors: Madolo S. D. , Telukdarie A. , Kumar A. 
Published: August 2018

Abstract
Water and energy are resources that are dependent on each other. Water is needed for the production of energy for fuel extraction, cooling power plants, and processing of fossil fuels. In water cycles, energy is needed for pumping, treatment and distribution of water and wastewater to and from customers. In South Africa (SA), the energy used in the water industry is generated mostly from fossil fuels, which has a significant negative impact on the environment. This research reviews a representative subset of the SA water industry to evaluate energy efficiency and harmful gas emissions optimisation potential. The first component of this study involves a review of the current energy efficiency potential in water distribution systems in SA. On the basis of a literature review, three technologies/practices were identified as being imperative in optimising water utilities in SA. The second part of this study involves the implementation of some performance indicators that illustrate the interdependence of water loss, energy consumption and CO2, NOX and SOX emissions. These indicators are used to compare a few possible mitigation scenarios involving water loss reduction and increasing the system's energy efficiency. The third component of research is developing a novel multi-layered structural water distribution system model by incorporating 29 metrics extracted from the literature reviewed. Analysis of this model is then conducted using a MULTI-MOORA (Multi-Objective Optimization by Ratio Analysis) technique accompanied by a Triangular Fuzzy Number set. The aim of this was to assist water utility managers to identify the most influential performance indicators for attaining the nexus objectives.
Adsorption of reactive dyes onto thermally treated waste from aluminum lamination
Authors: Fraga Tiago José Marques , dos Santos Marques Fraga Daysianne Mikaella , da Silva Tereza Cristina , Carvalho Marilda Nascimento , da Motta Sobrinho Maurício Alves 
Published: August 2018

Abstract
The lamination process of aluminum sheets generates a flammable oil-soaked waste, which had been thermally treated (TTW) and used as adsorbent of reactive Remazol Black B (RB) and Remazol Red RB133 (RR), two of the most used dyes in the printing processes on textile industries, with reported carcinogenic and toxic properties. The adsorbent was characterized by Brunauer-Emmett-Teller (BET)-specific surface area, scanning electron microscopy and X-ray diffraction analysis. Kinetic and equilibrium studies were performed to evaluate the TTW adsorption parameters and the isotherm model which best represented the process. It was observed that the system reached the equilibrium state after 5 min for both dyes and obtained their maximum adsorption capacity (qm) at pH 4: 0.69 mg·g−1 and 2.89 mg·g−1, for RB and RR respectively; moreover, the pseudo-second-order model better fitted the adsorption kinetics. The equilibrium data were better fitted to Langmuir isotherm compared to Freundlich's for the RB and RR adsorption. The maximum removal efficiency obtained in the experiments was 80.2% for RB and 80% for RR; moreover, after the acid activation of TTW, the RB removal efficiency increased from 84.9% to 93.7%.
Application of multiple regression analysis in projecting the water demand for the City of Cape Town
Authors: Lawens M. , Mutsvangwa C. 
Published: August 2018

Abstract
Historically, the city of Cape Town has been affected by water shortages and it can be assumed that the situation will be exacerbated in the coming decades by a growing population, economic development and climatic changes as additional stress factors. In order to defuse the situation, the city of Cape Town has commissioned various feasibility studies concerning the implementation of alternative water sources, with as yet unpublished conclusions. Since sustainable water resource planning requires a comprehensive understanding of the water demand, the objective of this study was to predict the future demand by the city of Cape Town by analysing its significant drivers. For this purpose, a linear multiple regression analysis was applied on parameters which influence water demand, namely: population, economy, water losses and water restrictions. In order to establish the linear multiple regression model and its regression coefficients, historical data was used for the period 2001 to 2012. The result of the regression analysis showed that the water demand of the city of Cape Town is only decisively influenced by population and water losses. In addition, the model indicated that a new source would be required by 2021. Thus, water conservation and water supply strategies can be adapted accordingly to ultimately enable a sustainable management of the water sources in the city of Cape Town.
Thioredoxin as a Therapeutic Target in Cerebral Ischemia
Authors: Zeng Xian-Si , Geng Wen-Shuo , Chen Lei , Jia Jin-Jing 
Published: August 2018

Background:
Cerebral ischemia is a common cause of disability and death. Ischemic brain injury results
from complex pathological processes, including oxidative stress, inflammation, and apoptosis. Thioredoxin(
Trx) is an important multifunctional protein, which regulates cellular redox status. Increasing studies have
demonstrated that Trx provides a neuroprotective role against cerebral ischemia-induced injury.

Methods:
A systematic search of PMC and the PubMed Database was conducted to summarize the protective
effects of Trx against cerebral ischemia.

Results:
This article reviews the understanding of potential effects and mechanisms of Trx against cerebral
ischemia, including the anti-oxidant, anti-apoptotic and anti-inflammatory effects, as well as the activation of prosurvival
pathway. We also summarize that some natural compounds induce the expression of Trx, which is involved
in their anti-ischemic effects.

Conclusion:
In conclusion, Trx has a potential neuroprotection in cerebral ischemia and may be very promising
for clinical therapy of ischemic stroke in the future.
Chinese Herbal Medicine Hepatotoxicity: The Evaluation and Recognization Based on Large-scale Evidence Database
Authors: Liu Zhi , He Xin , Wang Lili , Zhang Yunhua , Hai Yue , Gao Rui 
Published: August 2018

Background:Due to the special nature of Chinese Herbal medicine and the complexity of its clinical use, it is difficult to identify and evaluate its toxicity and resulting herb induced liver injury (HILI).Methods:First, the database would provide full profile of HILI from the basic ingredients to clinical outcomes by the most advanced algorithms of artificial intelligence, and it is also possible that we can predict possibilities of HILI after patients taking Chinese herbs by individual patient evaluation and prediction. Second, the database would solve the chaos and lack of the relevant data faced by the current basic research and clinical practice of Chinese Herbal Medicine. Third, we can also screen the susceptible patients from the database and thus prevent the accidents of HILI from the very beginning.Results:The Roussel Uclaf Causality Assessment Method (RUCAM) is the most accepted method to evaluate DILI, but at present before using the RUCAM evaluation method, data resource collection and analysis are yet to be perfected. Based on existing research on drug-metabolizing enzymes mediating reactive metabolites (RMs), the aim of this study is to explore the possibilities and methods of building multidimensional hierarchical database composing of RMs evidence library, Chinese herbal evidence library, and individualized reports evidence library of herb induced liver injury HILI.Conclusion:The potential benefits lie in its ability to organize, use vast amounts of evidence and use big data mining techniques at the center for Chinese herbal medicine liver toxicity research, which is the most difficult key point of scientific research to be investigated in the next few years.
Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug
Authors: Song Wei , Liu Meilin , Wu Junjun , Zhai Hong , Chen Yong , Peng Zhihong 
Published: August 2018

Background:Triptolide, a bioactive component in Tripterygium wilfordii extracts, possess strong antiproliferative activity on all 60-National Cancer Institute (NCI) cancer cell lines. However, the widespread use of triptolide in the clinical practice is greatly limited for its multi-organ toxicity and narrow therapeutic window. All the toxic characteristics of triptolide are associated with the pharmacokinetics especially its distribution and accumulation in the target organ.Methods:The literature review was done using PubMed search, SciFinder and Google Scholar databases with specific keywords such as triptolide, pharmacokinetics, drug-drug interaction, transporters, metabolism, modification to collect the related full-length articles and abstracts from 2000 to 2018.Results:Oral triptolide is rapidly and highly absorbed. Grapefruit juice affects oral absorption, increasing the area under the concentration-time curve (AUC) by 153 % and the maximum concentration (Cmax) by 141 %. The AUC and the Cmax are not dose proportional. Triptolide distributes into the liver, heart, spleen, lung and kidney. Biotransformation of triptolide in rats includes hydroxylation, sulfate, glucuronide, N-acetylcysteine (NAC) and Glutathione (GSH) conjugation and combinations of these pathways. Less than 4 % of triptolide was recovered from the feces, bile and urine within 24 h. After repeating dosage, triptolide was eliminated quickly without accumulation in vivo. As a substrate of P-glycoprotein (P-gp) and CYP3A4, triptolide could have clinically significant pharmacokinetic interactions with those proteins substrates/inhibitors.Conclusion:The findings of this review confirm the importance of pharmacokinetic character for understanding the pharmacology and toxicology of triptolide.
Novel Therapeutic Potential of Mitogen-Activated Protein Kinase Activated Protein Kinase 2 (MK2) in Chronic Airway Inflammatory Disorders
Authors: Singh Rakesh Kumar , Najmi Abul Kalam 
Published: August 2018

Objective:
The primary focus of this review is to highlight the current and emerging proinflammatory
role of MK2 kinase signaling in p38MAPK pathway and to provide a detailed evaluation
on the prospects of MK2 inhibition with special emphasis on the etiology of chronic inflammatory
airway diseases, such as asthma, idiopathic pulmonary fibrosis, lung cancer, acute lung injury and
acute respiratory distress syndrome.

Background:
MK2 belongs to serine-threonine kinase family and is activated directly by stress and
inflammatory signal through p38MAPK phosphorylation in diverse inflammatory conditions through
the Toll-like receptor signaling pathway. MK2 has been thought to be a critical factor involved in the
regulation of synthesis and release of pro-inflammatory (TNF-α, IL-6 and IL-1β, etc.) proteins. Targeted
inhibition of MK2 kinase has been shown to significantly reduce the production and release of
these cytokine molecules. Therefore, MK2 has been identified as an effective strategy (alternative to
p38MAPK) to block this pro-inflammatory signaling pathway.

Results:
The inhibition of MK2 may lead to similar or better efficacy as that of p38 inhibitors, and interestingly
avoids the systemic toxicity shown by the p38 inhibitors. Thus, MK2 has been the focus of
intense interdisciplinary research and its specific inhibition can be a novel and potential therapeutic
strategy for the treatment of chronic airway inflammatory diseases.

Conclusion:
Promising advancement in understanding and rigorous exploration of the role of MK2
kinase in inflammatory processes may contribute to the development of newer and safer therapy for
the treatment of chronic airway inflammatory diseases in the future.
Psychopharmacological Treatment of Obsessive-Compulsive Disorder (OCD)
Authors: Del Casale Antonio , Sorice Serena , Padovano Alessio , Simmaco Maurizio , Ferracuti Stefano , Lamis Dorian A. , Rapinesi Chiara , Sani Gabriele , Girardi Paolo , Kotzalidis Georgios D. , Pompili Maurizio 
Published: August 2018

Background:Obsessive-compulsive disorder (OCD) is associated with affective and cognitive symptoms causing personal distress and reduced global functioning. These have considerable societal costs due to healthcare service utilization.Objective:Our aim was to assess the efficacy of pharmacological interventions in OCD and clinical guidelines, providing a comprehensive overview of this field.Methods:We searched the PubMed database for papers dealing with drug treatment of OCD, with a specific focus on clinical guidelines, treatments with antidepressants, antipsychotics, mood stabilizers, off-label medications, and pharmacogenomics.Results:Prolonged administration of selective serotonin reuptake inhibitors (SSRIs) is most effective. Better results can be obtained with a SSRI combined with cognitive behavioral therapy (CBT) or the similarly oriented exposure and response prevention (ERP). Refractory OCD could be treated with different strategies, including a switch to another SSRI or clomipramine, or augmentation with an atypical antipsychotic. The addition of medications other than antipsychotics or intravenous antidepressant administration needs further investigation, as the evidence is inconsistent. Pharmacogenomics and personalization of therapy could reduce treatment resistance.Conclusion:SSRI/clomipramine in combination with CBT/ERP is associated with the optimal response compared to each treatment alone or to other treatments. New strategies for refractory OCD are needed. The role of pharmacogenomics could become preponderant in the coming years.
Gender Differences in Types, Frequency, Clinical Manifestations and Atherosclerotic Burden of Coronary Artery Anomalies
Authors: Yousif Nooraldaem , Shahin Mohammady , Lüscher Thomas F. , Obeid Slayman 
Published: August 2018

Background:
Although not well established; gender may play a role in the incidence, clinical
manifestations, and atherosclerotic burden of Coronary Artery Anomalies (CAAS). Our aim is to
investigate the impact of gender on coronary artery anomalies.
</P><P>
Methods: All coronary angiograms performed at the University Heart Center Zurich, Switzerland, between
January 2000 and December 2016 were investigated. Those of anomalous origin, course and
termination (fistula) were included in the analysis with the exclusion of coronary artery aneurysms and
myocardial bridges.

Results:
Out of the original 39577 angiographic studies that included 28550 males and 11026 females,
Coronary Artery Anomalies (CAAS) were documented in 130 (0.32%) patients of whom 69.2%
(n=90) and 30.8%(n=40) were males and females respectively. However, the overall prevalence of
coronary anomalies amongst both genders did not differ (0.32% vs 0.36%, P = 1) and so were the
basic characteristics except for hypertension, which was more prevalent in females (P = 0.03644). The
most prevalent anomaly overall was (left circumflex artery from right coronary artery/sinus), which
was present in (n=47, 36.2%). No impact of gender on the incidence of individual anomalies except
for Right Coronary Artery (RCA) originating from Left Circumflex Artery (LCX), which was only
documented in men (P = 0.0000116). On the other hand malignant CAAS presented equally with a
proportion of 10% for both genders (P = 1). Although males outnumbered females in terms of atherosclerotic
burden in CAAS this was statistically not significant (P = 0.331).

Conclusion:
Both genders have a similar impact on the overall prevalence, clinical manifestations and
atherosclerotic burden of CAAs. Anomaly of RCA originating from LCX occurred more frequently in
males than females.
Recent Advances of Useful Cell Sources in the Periodontal Regeneration
Authors: Cho Young-Dan , Kim Kyoung-Hwa , Ryoo Hyun-Mo , Lee Yong-Moo , Ku Young , Seol Yang-Jo 
Published: August 2018

Background:
Periodontitis is an inflammatory disease that can result in destruction of the
tooth attachment apparatus. Therefore, periodontal tissue regeneration is currently an important focus of
research in the field. Approaches using stem cells and reprogrammed cells, such as induced pluripotent
stem cells (iPSCs) or trans-differentiated cells, represent the cutting edge in periodontal regeneration,
and have led to many trials for their clinical application.

Objectives and Results:
In this review, we consider all available stem cell sources, methods to obtain
the cells, their capability to differentiate into the desired cells, and the extent of their utilization in
periodontal regeneration. In addition, we introduce the new concepts of using iPSCs and transdifferentiated
cells for periodontal regeneration. Finally, we discuss the promise of tissue engineering
for improving cell therapy outcomes for periodontal regeneration.

Conclusions:
Despite their limitations, iPSCs and trans-differentiated cells may be promising cell
sources for periodontal tissue regeneration. Further collaborative investigation is required for the effective
and safe application of these cells in combination with tissue engineering elements, like scaffolds
and biosignals.