bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood Pressure Responses in Isokinetic Dynamometry Test in Elderly Community Women: An Exploratory Study
Authors: Letieri Rubens Vinícius , Furtado Guilherme Eustáquio , Rieping Taís , Farias Mayrhon José Abrantes , Teixeira Ana Maria Miranda Botelho 
Published: January 2019

The aim of the study was to verify the systolic, diastolic and mean arterial pressure response in elderly women during isokinetic test. The study included 54 females (68.8 ± 5.9 years) divided into two age groups (Group 1: 60 to 70 and group 2: above 71 years). BP was measured before and immediately after the isokinetic knee extension / flexion test in the concentric-concentric mode. After the test, significant elevations were observed in relation to the pre-test in SBP (G1: Δ% = 29.7%, G2: Δ% = 20.6%, p <.01, respectively) and in MAP (G1: Δ% = 7.6 %, G2: Δ% = 8.4%, p <.01, respectively). The use of isokinetic tests produces elevations in systolic blood pressure and mean arterial pressure in elderly women. Increases occur independently of the age group studied. However, the increases detected do not appear to be of sufficient magnitude to constitute a health hazard whereby isokinetic tests can be safely applied in this population.
Türkiye Hayvancılık Sektöründe e-Ticaret Engelleri / E-Commerce Barriers in Turkish Livestock Sector
Authors: Aksu Murat , Gürbüz Ahmet 
Published: January 2019

<p><strong>Abstract</strong></p><p>Electronic commerce (e-commerce); computer, or a device that may be able to perform the same function, and products produced with the help of internet networks, advertising, sales, payment and after-sales service activities. However, the rate of use of e-commerce is not at expected levels for almost every sector and company. Livestock; the economic value of animals, the use of various forms of marketing and marketing. According to TUIK data, the number of bovine animals is approximately 16 million, the number of small ruminants is 45 million, and the number of poultry is 350 million for 2017 year. When you look at the size of the figures, it is a problem that the livestock sector does not spread even though it forms a market large enough for e-commerce.</p><p>The study was conducted to investigate the reasons for not using the e-commerce system of farmers engaged in animal husbandry in Tokat province and e-commerce hurdles were measured with 20 variables. The research was carried out on 310 animal owners in Tokat province, who voluntarily participated in the face-to-face survey. In the study, factor analysis was conducted to determine the groups of e-commerce hurdles. Whether e-commerce barriers differ according to demographic variables such as education level and number of animals is examined and results and suggestions are presented in the direction of the findings obtained.</p><p><strong>Öz</strong></p><p>Elektronik ticaret (e-ticaret); bilgisayar veya aynı işlevi görebilecek bir aygıt ve internet ağları yardımıyla üretilen ürünlerin tanıtılması ve reklamının yapılması, satılması, ödeme ve satış sonrası hizmet faaliyetleri olarak tanımlanabilir. Ancak hemen hemen her sektör ve işletme için avantaj oluşturacağı düşünülen e-ticaretin kullanım oranı beklenen seviyelerde değildir. Hayvancılık; ekonomik değeri olan hayvanların yetiştirilmesi, çeşitli şekillerde yararlanılması ve pazarlanması durumudur. TÜİK verilerine bakıldığında 2017 yılı için büyükbaş hayvan sayısı yaklaşık 16 milyon civarı, küçükbaş hayvan sayısı 45 milyon civarı, kümes hayvanı sayısı ise 350 milyon civarıdır. Rakamların büyüklüğüne bakıldığında hayvancılık sektörünün e-ticaret için yeterli büyüklükte bir pazar oluşturmasına rağmen yaygınlaşmaması bir sorunsaldır.</p><p>Çalışmada Tokat ilinde hayvancılıkla uğraşan çiftçilerin e-ticaret sistemini kullanmama sebepleri araştırılmış ve e-ticaret engelleri 20 değişken ile ölçülmüştür. Araştırma, yüz yüze anket yöntemiyle katılımı gönüllü olarak kabul eden, Tokat ilinde bulunan 310 hayvan sahibine yapılmıştır. Çalışmada e-ticaret engellerinin guruplarını saptamak için faktör analizi yapılmıştır. E-ticaret engellerinin eğitim durumu ve hayvan sayısı gibi demografik değişkenlere göre farklılaşıp farklılaşmadığına bakılmış ve elde edilen bulgular doğrultusunda sonuç ve öneriler sunulmuştur. </p>
Rate of positive depression screenings among Marshallese patients with diabetes in Northwest Arkansas
Authors: Seaton Victoria A. , Dickey Tiffany A. , Balli Michelle L. , Briggs Bradley E. , Baker Jessicca D. , Hudson Jonell S. 
Published: January 2019

AbstractIntroductionThe lifetime risk of developing depression is 16.6%, however the risk is 2-fold in patients with diabetes. The rate of diabetes is much higher for the Marshallese than the general US population, with a prevalence ranging from 25% to 50%, however the prevalence of depression is not well defined among this minority group. The primary objective of this study was to obtain the rate of positive depression screenings, using the Patient Health Questionnaire-2 (PHQ-2), among adult Marshallese patients with diabetes.MethodsA retrospective chart review was performed for Marshallese adults receiving care in a student-led clinic in Northwest Arkansas. Marshallese adults with a documented PHQ-2 score and a diagnosis of type 1 or 2 diabetes, as outlined by the American Diabetes Association, were included. Demographic information was obtained from the medical records. The data were analyzed using descriptive statistics.ResultsThe study included 96 patients. Ten patients scored a 3 or higher on the PHQ-2, indicating a positive screen. Of these, scores ranged from 3 to 6, with the majority of patients scoring 4 (N = 6). The average hemoglobin A1C for patients with a positive PHQ-2 score was 10.5%.DiscussionThis project identified a rate of 10.4% of patients with a positive PHQ-2 from the study sample. This finding is similar to the prevalence of depression for the general US population, however it is lower than rates cited in the literature for patients diagnosed with diabetes. Future studies should use Native Marshallese community health workers and focus groups to develop a multistep approach to obtain a culturally appropriate, translated tool with high sensitivity for patient response.
A novel CPT1C variant causes pure hereditary spastic paraplegia with benign clinical course
Authors: Hong Daojun , Cong Lu , Zhong Shanshan , Liu Ling , Xu Yan , Zhang Jun 
Published: January 2019

AbstractHereditary spastic paraplegia 73 (SPG73) was currently identified in only one family with variant in the neuronal isoform of carnitine palmitoyl‐transferase 1C (CPT1C) gene. We described a new family, in which affected individuals exhibited pure hereditary spastic paraplegia with benign clinical course. Exome sequencing revealed a novel nonsense variant in the CPT1C gene. The level of CPT1C mutant transcript significantly decreased compared to that of wild‐type transcript, and can be recovered after cycloheximide administration, which indicated that nonsense‐mediated mRNA decay was a mechanism that might be responsible for the phenotype. Our findings expanded the clinical and genetic spectrum of SPG73.
Tungsten‐Doping‐Induced Surface Reconstruction of Porous Ternary Pt‐Based Alloy Electrocatalyst for Oxygen Reduction
Authors: Tu Wenzhe , Chen Kai , Zhu Lujun , Zai Huachao , E Bin , Ke Xiaoxing , Chen Changfeng , Sui Manling , Chen Qi , Li Yujing 
Published: January 2019

AbstractSurface engineering has been found to be effective in promoting the catalytic activities of noble‐metal‐based nanocatalysts. In this contribution, by using the PtCuxNi ternary alloy nanocrystal (NC) as the model catalyst, a surface tungsten(W)‐doping strategy, combining a surface oxidative acid treatment protocol, can effectively boost the electrocatalytic activities of the NCs in oxygen reduction reaction. The W‐doped PtCuxNi alloy catalysts show obvious enhancement in electrochemical surface area and mass activity and slightly enhanced specific activity compared with the undoped catalyst. Based on the experimental evidence, it is proposed that the W doping involves a surface reconstruction by first removing the surface Pt atoms from the NC and then reducing them back to the surface. The existence of surface Ni atoms may be crucial in promoting the catalytic activities possibly through their electronic interactions to the active sites. The durability of the W‐doped PtCuxNi catalysts is also enhanced possibly due to the pinning effect of surface W atoms. Therefore, the surface engineering of PtCuxNi ternary alloy by W atoms can effectively modulate its activity and durability.
Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way
Authors: Wei Ting , Yu Qian , Chen Hong 
Published: January 2019

AbstractAntibacterial coatings that eliminate initial bacterial attachment and prevent subsequent biofilm formation are essential in a number of applications, especially implanted medical devices. Although various approaches, including bacteria‐repelling and bacteria‐killing mechanisms, have been developed, none of them have been entirely successful due to their inherent drawbacks. In recent years, antibacterial coatings that are responsive to the bacterial microenvironment, that possess two or more killing mechanisms, or that have triggered‐cleaning capability have emerged as promising solutions for bacterial infection and contamination problems. This review focuses on recent progress on three types of such responsive and synergistic antibacterial coatings, including i) self‐defensive antibacterial coatings, which can “turn on” biocidal activity in response to a bacteria‐containing microenvironment; ii) synergistic antibacterial coatings, which possess two or more killing mechanisms that interact synergistically to reinforce each other; and iii) smart “kill‐and‐release” antibacterial coatings, which can switch functionality between bacteria killing and bacteria releasing under a proper stimulus. The design principles and potential applications of these coatings are discussed and a brief perspective on remaining challenges and future research directions is presented.
An Ionic Capacitor for Integrated Iontronic Circuits
Authors: Janson Per , Gabrielsson Erik O. , Lee Keon Jae , Berggren Magnus , Simon Daniel T. 
Published: January 2019

AbstractOrganic electronics, in combination with custom polyelectrolytes, enables solid‐ and hydrogel‐state circuit components using ionic charges in place of the electrons of traditional electronics. This growing field of iontronics leverages anion‐ and cation‐exchange membranes as analogs to n‐type and p‐type semiconductors, and conjugated polymer electrodes as ion‐to‐electron converters. To date, the iontronics toolbox includes ionic resistors, ionic diodes, ionic transistors, and analog and digital circuits comprised thereof. Here, an ionic capacitor based on mixed electron–ion conductors is demonstrated. The ionic capacitor resembles the structure of a conventional electrochemical capacitor that is inverted, with an electronically conducting core and two electrolyte ionic conductors. The device is first verified as a capacitor, and then demonstrated as a smoothing element in an iontronic diode bridge circuit driving an organic electronic ion pump (ionic resistor). The ionic capacitor complements the existing iontronics toolbox, enabling more complex and functional ionic circuits, and will thus have implications in a variety of mixed electron–ion conduction technologies.
Multifunctional Skin‐Inspired Flexible Sensor Systems for Wearable Electronics
Authors: Xu Kaichen , Lu Yuyao , Takei Kuniharu 
Published: January 2019

AbstractSkin‐inspired wearable devices hold great potentials in the next generation of smart portable electronics owing to their intriguing applications in healthcare monitoring, soft robotics, artificial intelligence, and human–machine interfaces. Despite tremendous research efforts dedicated to judiciously tailoring wearable devices in terms of their thickness, portability, flexibility, bendability as well as stretchability, the emerging Internet of Things demand the skin‐interfaced flexible systems to be endowed with additional functionalities with the capability of mimicking skin‐like perception and beyond. This review covers and highlights the latest advances of burgeoning multifunctional wearable electronics, primarily including versatile multimodal sensor systems, self‐healing material‐based devices, and self‐powered flexible sensors. To render the penetration of human‐interactive devices into global markets and households, economical manufacturing techniques are crucial to achieve large‐scale flexible systems with high‐throughput capability. The booming innovations in this research field will push the scientific community forward and benefit human beings in the near future.
The Contacts of the Monolayer Semiconductor C2N with 2D Metal Electrodes
Authors: Chen Zhao , Li Xingxing , Yang Jinlong 
Published: January 2019

AbstractFor its easy synthesis, suitable band gap, and fine optoelectronic properties, the carbon nitride sheet C2N acts as a promising candidate material for nanoelectronics. To achieve a high‐performance C2N device, ohmic contact with metal electrodes is urgently needed. Here, based on first principles calculations, the monolayer (ML) C2N contacts with a series of 2D metal electrodes—surface‐engineered MXenes (Hf2C(OH)2, Nb2CF2, Mo2NO2) and metallic transition metal dichalcogenides (T‐VSe2, T‐VS2, H‐TaS2)—are systematically studied. With clean and saturated surfaces, these 2D metals form van der Waals (vdW) contacts with C2N, which exhibit a weak Fermi level pinning and tunable Schottky barriers. While n‐type Schottky barriers are observed for Nb2CF2/T‐VSe2 electrodes and p‐type for T‐VS2/Mo2NO2/H‐TaS2 electrodes due to their different sizes of work functions, ohmic contact is found for Hf2C(OH)2 electrode with its work function significantly smaller than electron affinity of ML C2N. Device simulations of field effect transistors based on C2N further confirmed the finding. This paper presents a fundamental understanding of 2D metal–C2N contacts and will help the future design of well‐performing C2N devices.
A Ternary Fe1−xS@Porous Carbon Nanowires/Reduced Graphene Oxide Hybrid Film Electrode with Superior Volumetric and Gravimetric Capacities for Flexible Sodium Ion Batteries
Authors: Liu Yang , Fang Yongjin , Zhao Zhiwei , Yuan Changzhou , Lou Xiong Wen (David) 
Published: January 2019

AbstractSmart construction of ultraflexible electrodes with superior gravimetric and volumetric capacities is still challenging yet significant for sodium ion batteries (SIBs) toward wearable electronic devices. Herein, a hybrid film made of hierarchical Fe1−xS‐filled porous carbon nanowires/reduced graphene oxide (Fe1−xS@PCNWs/rGO) is synthesized through a facile assembly and sulfuration strategy. The resultant hybrid paper exhibits high flexibility and structural stability. The multidimensional paper architecture possesses several advantages, including rendering an efficient electron/ion transport network, buffering the volume expansion of Fe1−xS nanoparticles, mitigating the dissolution of polysulfides, and enabling superior kinetics toward efficient sodium storage. When evaluated as a self‐supporting anode for SIBs, the Fe1−xS@PCNWs/rGO paper electrode exhibits remarkable reversible capacities of 573–89 mAh g−1 over 100 consecutive cycles at 0.1 A g−1 with areal mass loadings of 0.9–11.2 mg cm−2 and high volumetric capacities of 424–180 mAh cm−3 in the current density range of 0.2–5 A g−1. More competitively, a SIB based on this flexible Fe1−xS@PCNWs/rGO anode demonstrates outstanding electrochemical properties, thus highlighting its enormous potential in versatile flexible and wearable applications.
Facile Synthesis of Unsymmetrical 2,5‐Disubstituted 1,3,4‐Oxadiazoles by Cyclization of gem‐Difluoroalkenes with Acyl Hydrazides
Authors: Zhang Xuxue , He Jingjing , Cao Song 
Published: January 2019

AbstractA mild and efficient method for the synthesis of unsymmetrical 2,5‐disubstituted 1,3,4‐oxadiazoles by condensation of gem‐difluoroalkenes with acyl hydrazides was developed. The cyclization reaction proceeds smoothly with the assistance of Cs2CO3, affording a variety of 1,3,4‐oxadiazoles in good to excellent yields. The reaction also exhibits a broad substrate scope and good functional group compatibility.
EyeChrom and CCDBcurator: Visualizing chromosome count data from plants
Authors: Rivero Rodrigo , Sessa Emily B. , Zenil‐Ferguson Rosana 
Published: January 2019

Premise of the StudyChromosome count data are available for hundreds of plant species and can be explored in text‐only format at the Chromosome Counts Database (http://ccdb.tau.ac.il). CCDBcurator and EyeChrom are an R package and a web application, respectively, that first curate and then visualize these data graphically, so that intra‐ and interspecific variation of chromosome numbers can be easily summarized and displayed for a given genus.Methods and ResultsWe developed R code to clean, summarize, and display in several formats the chromosome count data for a selected genus or set of species present in the Chromosome Counts Database. These data and figures can be exported for use in analyses, publications, or teaching.ConclusionsChromosome count data are critical for a number of evolutionary studies in plant biology, and their importance is underscored by the increasing appreciation of the prevalence of polyploidy in land plants. CCDBcurator and EyeChrom provide a fast, easy, and reproducible means of cleaning, curating, and then visualizing the chromosome count data currently available for plants.
Preparation and anti‐tumor efficiency evaluation of bacterial magnetosome–anti‐4‐1BB antibody complex: Bacterial magnetosome as antibody carriers isolated from Magnetospirillum gryphiswaldense
Authors: Tang Yi‐Shu , Wang Dongmei , Zhou Chunxia , Zhang Shuren 
Published: January 2019

AbstractBacterial magnetosomes (BMs) are used as carriers for antibodies, enzymes, and nucleic acids. This study aimed to demonstrate the clinical utility of BMs derived from Magnetospirillum gryphiswaldense for use in anti‐tumor immunotherapy. Bis(sulfosuccinimidyl) suberate (BS3) was used to prepare BM–anti‐4‐1BB antibody complexes. We used syngeneic TC‐1 mouse models of cancer to investigate whether BMs combined with an anti‐4‐1BB agonistic antibodies could enhance the therapeutic effects of anti‐4‐1BB antibodies in localized disease settings. Anti‐4‐1BB antibodies were combined with purified BMs at a concentration of 168 mg antibody per milligram BM (mg IgG/mg BM) using BS3. The anti‐4‐1BB antibody‐coupled BMs (BM–Ab complexes) and control BMs displayed similar morphologies and measurements when examined by transmission electron microscope (TEM). In a mouse tumor model, intravenous injection of BM–Abs combined with magnetic treatment resulted in greater tumor protection than did other treatment methods (P < 0.05). These results demonstrate the in vivo anti‐tumor properties of BM–Abs complexes. The coupling of anti‐4‐1BB antibodies to magnetosomes may have potential for clinical application to antitumor antibody therapy.
Mid‐P confidence intervals for group testing based on the total number of positive groups
Authors: Hepworth Graham , Katholi Charles R. 
Published: January 2019

AbstractIn the estimation of proportions by group testing, unequal sized groups results in an ambiguous ordering of the sample space, which complicates the construction of exact confidence intervals. The total number of positive groups is shown to be a suitable statistic for ordering outcomes, provided its ties are broken by the MLE. We propose an interval estimation method based on this quantity, with a mid‐P correction. Coverage is evaluated using group testing problems in plant disease assessment and virus transmission by insect vectors. The proposed method provides good coverage in a range of situations, and compares favorably with existing exact methods.
Tocotrienol and cancer metastasis
Authors: De Silva Leanne , Chuah Lay Hong , Meganathan Puvaneswari , Fu Ju‐Yen 
Published: January 2019

AbstractTumor metastasis involves some of the most complex and dynamic processes in cancer, often leading to poor quality of life and inevitable death. The search for therapeutic compounds and treatment strategies to prevent and/or manage metastasis is the ultimate challenge to fight cancer. In the past two decades, research focus on vitamin E has had a shift from saturated tocopherols to unsaturated tocotrienols (T3). Despite sharing structural similarities with tocopherols, T3 strive to gain scientific prominence due to their anti‐cancer effects. Recent studies have shed some light on the anti‐metastatic properties of T3. In this review, the roles of T3 in each step of the metastatic process are discussed. During the invasion process, signaling pathways that regulate the extracellular matrix and tumor cell motility have been reported to be modulated by T3. Although studies on T3 and tumor cell migration are fairly limited, they were shown to play a vital role in the suppression of angiogenesis. Furthermore, the anti‐inflammatory effect of T3 could be highly promising in the regulation of tumor microenvironment, which is crucial in supporting tumor growth in distant organs. © 2016 BioFactors, 42(2):149–162, 2016
The Telomerization of 1,3‐Dienes – A Reaction Grows Up
Authors: Faßbach Thiemo A. , Vorholt Andreas J. , Leitner Walter 
Published: January 2019

AbstractTelomerization is a versatile tool for synthesizing unsaturated ethers, amines and other molecules starting from 1,3‐dienes and respective nucleophiles. The homogeneously catalyzed reaction has been the subject of academic and industrial research for over 50 years, offering a broad variety of substrates, catalysts and process concepts. This Minireview presents the advances and developments in this field over the last decade. The focus was on the conversion of renewable resources, the synthesis of promising new products and the development of efficient process concepts to combine these.
Facile Dynamic Synthesis of Homodispersed Ni3S2 Nanosheets as a High‐Efficient Bifunctional Electrocatalyst for Water Splitting
Authors: Li Yuting , Bu Yunfei , Chen Xiaoyang , Zhu Tenglong , Wang Juan , Kawi Sibudjing , Zhong Qin 
Published: January 2019

AbstractIt is extremely significant but still challenging to develop effective and stable electrocatalysts for water splitting, which is recommended as a promising technology to produce hydrogen. Herein, leaf‐like Ni3S2 nanosheets grown on the nickel foam fabricated by a novel one‐step dynamic hydrothermal method is demonstrated. Based on the new method, such catalyst with high and uniform dispersion exhibits superior activity and stability for both hydrogen evolution reaction and oxygen evolution reaction in basic electrolyte. Moreover, the as‐prepared Ni3S2 as two electrode catalysts of overall water splitting exhibits remarkable bifunctional activities with a small cell voltage of 1.45 V at a current density of 10 mA cm−2. This work can provide a new prospect for optimizing Ni3S2 growth to enhance its electrocatalytic performances.