bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1–Dependent Neonatal Murine Sepsis Lethality
Authors: Benjamin John T. , Moore Daniel J. , Bennett Clayton , van der Meer Riet , Royce Ashley , Loveland Ryan , Wynn James L. 
Published: October 2018

Abstract
Sepsis disproportionately affects the very old and the very young. IL-1 signaling is important in innate host defense but may also play a deleterious role in acute inflammatory conditions (including sepsis) by promulgating life-threatening inflammation. IL-1 signaling is mediated by two distinct ligands: IL-1α and IL-1β, both acting on a common receptor (IL-1R1). IL-1R1 targeting has not reduced adult human sepsis mortality despite biologic plausibility. Because the specific role of IL-1α or IL-1β in sepsis survival is unknown in any age group and the role of IL-1 signaling remains unknown in neonates, we studied the role of IL-1 signaling, including the impact of IL-1α and IL-1β, on neonatal murine sepsis survival. IL-1 signaling augments the late plasma inflammatory response to sepsis. IL-1α and not IL-1β is the critical mediator of sepsis mortality, likely because of paracrine actions within the tissue. These data do not support targeting IL-1 signaling in neonates.
The relationship between social support and participation in stroke: A systematic review
Authors: Elloker Toughieda , Rhoda Anthea J. 
Published: October 2018

Background: The incidence of cerebrovascular accidents with its devastating effects on individuals is increasing. Post-stroke, restrictions in participation are common and social support could have an influence on this. Social support provided to individuals post-stroke is vital, but the relationship between social support and participation is not well understood.Objectives: This review aimed to systematically determine the relationship between social support and participation post-stroke, based on the literature available.Method: Ebscohost, Science Direct, Biomed Central, Cochrane Library, Google Scholar, Pedro Central and Wiley Online were the electronic databases searched between 2001 and 2016. Articles were deemed to be eligible if they met the inclusion criteria and successfully underwent scrutiny to determine their relevance and methodological quality, using tools from the Critical Appraisal Skills Programme and Milton Keynes Primary Trust. A narrative synthesis method was used to analyse the included studies.Results: A total of 54 articles were identified after screening, and six articles were deemed eligible for inclusion. The articles consisted of cross-sectional, qualitative and cohort studies. Articles showed distinct, significant relationships between social support and participation where the quality and quantity of social support were important. High levels of social support had a positive influence on participation, social and leisure activities, as well as returning to work post-stroke.Conclusion: A positive relationship exists between social support and participation post-stroke. Health professionals need to include social support interventions when attempting to manage the individual with stroke holistically, as this will have positive effects on participation.
Ice crystal number concentration estimates from lidar–radar satellite remote sensing – Part 2: Controls on the ice crystal number concentration
Authors: Gryspeerdt Edward , Sourdeval Odran , Quaas Johannes , Delanoë Julien , Krämer Martina , Kühne Philipp 
Published: October 2018

Abstract. The ice crystal number concentration (Ni) is a key property of
ice clouds, both radiatively and microphysically. Due to sparse
in situ measurements of ice cloud properties, the controls on the
Ni have remained difficult to determine. As more advanced
treatments of ice clouds are included in global models, it is becoming
increasingly necessary to develop strong observational constraints on the
processes involved. This work uses the DARDAR-Nice Ni retrieval described in Part 1
to investigate the controls on the Ni at a global scale. The
retrieved clouds are separated by type. The effects of temperature, proxies
for in-cloud updraft and aerosol concentrations are investigated.
Variations in the cloud top Ni (Ni(top))
consistent with both homogeneous and heterogeneous nucleation are observed
along with differing relationships between aerosol and
Ni(top) depending on the prevailing meteorological
situation and aerosol type. Away from the cloud top, the Ni
displays a different sensitivity to these controlling factors, providing a
possible explanation for the low Ni sensitivity to temperature
and ice nucleating particles (INP) observed in previous in situ studies. This satellite dataset provides a new way of investigating the response of
cloud properties to meteorological and aerosol controls. The results
presented in this work increase our confidence in the retrieved
Ni and will form the basis for further study into the processes
influencing ice and mixed phase clouds.
A neural network aerosol-typing algorithm based on lidar data
Authors: Nicolae Doina , Vasilescu Jeni , Talianu Camelia , Binietoglou Ioannis , Nicolae Victor , Andrei Simona , Antonescu Bogdan 
Published: October 2018

Abstract. Atmospheric aerosols play a crucial role in the Earth's system,
but their role is not completely understood, partly because of the large
variability in their properties resulting from a large number of possible
aerosol sources. Recently developed lidar-based techniques were able to
retrieve the height distributions of optical and microphysical properties of
fine-mode and coarse-mode particles, providing the types of the aerosols. One
such technique is based on artificial neural networks (ANNs). In this
article, a Neural Network Aerosol Typing Algorithm Based on Lidar Data
(NATALI) was developed to estimate the most probable aerosol type from a set
of multispectral lidar data. The algorithm was adjusted to run on
the EARLINET 3β+2α(+1δ) profiles. The NATALI algorithm is
based on the ability of specialized ANNs to resolve the overlapping values of
the intensive optical parameters, calculated for each identified layer in the
multiwavelength Raman lidar profiles. The ANNs were trained using synthetic
data, for which a new aerosol model was developed. Two parallel typing
schemes were implemented in order to accommodate data sets containing (or not)
the measured linear particle depolarization ratios (LPDRs): (a) identification
of 14 aerosol mixtures (high-resolution typing) if the LPDR is available in
the input data files, and (b) identification of five predominant aerosol types
(low-resolution typing) if the LPDR is not provided. For each scheme, three
ANNs were run simultaneously, and a voting procedure selects the most
probable aerosol type. The whole algorithm has been integrated into a Python
application. The limitation of NATALI is that the results are strongly
dependent on the input data, and thus the outputs should be understood
accordingly. Additional applications of NATALI are feasible, e.g. testing the quality of
the optical data and identifying incorrect calibration or insufficient cloud
screening. Blind tests on EARLINET data samples showed the
capability of NATALI to retrieve the aerosol type from a large variety of
data, with different levels of quality and physical content.
Lidar temperature series in the middle atmosphere as a reference data set – Part 1: Improved retrievals and a 20-year cross-validation of two co-located French lidars
Authors: Wing Robin , Hauchecorne Alain , Keckhut Philippe , Godin-Beekmann Sophie , Khaykin Sergey , McCullough Emily M. , Mariscal Jean-François , d'Almeida Éric 
Published: October 2018

Abstract. The objective of this paper and its companion (Wing et al., 2018) is to show
that ground-based lidar temperatures are a stable, accurate, and precise
data set for use in validating satellite temperatures at high vertical
resolution. Long-term lidar observations of the middle atmosphere have been
conducted at the Observatoire de Haute-Provence (OHP), located in southern
France (43.93∘ N, 5.71∘ E), since 1978. Making use of
20 years of high-quality co-located lidar measurements, we have shown that
lidar temperatures calculated using the Rayleigh technique at 532 nm are
statistically identical to lidar temperatures calculated from the
non-absorbing 355 nm channel of a differential absorption lidar (DIAL)
system. This result is of interest to members of the Network for the
Detection of Atmospheric Composition Change (NDACC) ozone lidar community
seeking to produce validated temperature products. Additionally, we have
addressed previously published concerns of lidar–satellite relative warm bias
in comparisons of upper-mesospheric and lower-thermospheric (UMLT)
temperature profiles. We detail a data treatment algorithm which minimizes
known errors due to data selection procedures, a priori choices, and
initialization parameters inherent in the lidar retrieval. Our algorithm
results in a median cooling of the lidar-calculated absolute temperature
profile by 20 K at 90 km altitude with respect to the standard OHP
NDACC lidar temperature algorithm. The confidence engendered by the long-term
cross-validation of two independent lidars and the improved lidar temperature
data set is exploited in Wing et al. (2018) for use in multi-year satellite
validations.
Faking the News: Intentional Guided Variation Reflects Cognitive Biases in Transmission Chains Without Recall
Authors: Stubbersfield Joseph , Tehrani Jamshid , Flynn Emma 
Published: October 2018

Abstract
Two potential forms of mutation in cultural evolution have been identified: ‘copying error’, where learners make random modifications to a behaviour and ‘guided variation’ where learners makes non-random modifications. While copying error is directly analogous to genetic mutation, guided variation is a specifically cultural process that does not have a close parallel in biological evolution. It has been suggested that the decision-making processes underlying intentional guided variation may produce similar results to cultural transmission as both are likely to be influenced by cognitive biases. This study uses a unique linear transmission chain design, without any influence of recall, to examine intentional guided variation. Participants were asked to alter news stories however they wished in order to make them more interesting, the product of their modification was then passed to the next participant and so on down the chain. The products of the chains were then compared with the original material so as to assess any underlying biases in the changed content. Through this process of guided variation, original material which scored low for bias-exploiting content significantly increased in at least one known content bias, whereas original material which scored high for bias-exploiting content was not significantly altered in this respect.
Grensoverschrijdende fraudebestrijding?
Authors: Walter T. 
Published: October 2018

Grensoverschrijdende fraudebestrijding? De interpretatie van artikel 225 Sr als Nederlandse variant van de Amerikaanse books and records provisions
In deze bijdrage wordt gesteld dat het Openbaar Ministerie in grote corruptiezaken een interpretatie geeft aan valsheid in geschrift, die gebaseerd lijkt te zijn op de Amerikaanse books and records provisions. Het Nederlandse strafbare feit valsheid in geschrifte en de books and records provisions worden in deze bijdrage met elkaar vergeleken, en er wordt geconcludeerd dat valsheid in geschrift, in het bijzonder valsheid van bedrijfsadministratie, een aanzienlijk beperktere reikwijdte heeft dan de books and records provisions. De interpretatie die het Openbaar Ministerie aan valsheid in geschrift lijkt te hebben gegeven in recente fraudezaken, dient dan ook met enige argwaan te worden beschouwd.
Criminele inmenging in sportverenigingen een probleem?!
Authors: Vrouwenfelder J. , Liem V. 
Published: October 2018

Criminele inmenging in sportverenigingen een probleem?! Een korte verkenning van problemen van financieel-economische criminaliteit in de sportwereld aan de hand van cases uit de praktijk
Sport en criminaliteit zijn twee zaken die op het eerste gezicht niet goed samen lijken gaan. Toch zien we met regelmaat berichten waarin sport en criminaliteit met elkaar in verband worden gebracht. Uit een recent onderzoek volgt onder meer dat personen met een dubieuze achtergrond zich regelmatig positief proberen te profileren met het steunen van maatschappelijk nuttige activiteiten. Ze sponsoren bijvoorbeeld sportverenigingen. Minimaal een op de drie Nederlandse gemeenten kent wel een dergelijke (criminele) ‘weldoener’. Tijd voor een korte verkenning van problemen van financieel-economische criminaliteit in de sportwereld.
Naar een meer samenhangend mededingings- en gegevensbeschermingstoezicht in datagedreven markten
Authors: Graef Inge 
Published: October 2018

Naar een meer samenhangend mededingings- engegevensbeschermingstoezicht in datagedreven markten
Deze bijdrage betoogt dat het mededingings- en gegevensbeschermingstoezicht beter op elkaar afgestemd moeten worden om consumentenbelangen in datagedreven markten te waarborgen. De nasleep van de Facebook/WhatsApp-concentratie laat zien dat het toezicht op digitale markten te wensen overlaat, ondanks de vele handhavingsacties in verschillende lidstaten. Vanuit het perspectief van het mededingingsrecht worden aanbevelingen voor een meer samenhangend toezicht op misbruik van economische machtspositie en concentraties gedaan, zowel inhoudelijk bij de toepassing van concepten als institutioneel bij het uitoefenen van bevoegdheden door de betreffende toezichthouders. Geconcludeerd wordt dat er ruimte is voor synergieën maar dat er ook sprake kan zijn van spanning tussen de twee rechtsgebieden.
Beoordeling van datamacht in het mededingingstoezicht
Authors: Stil Robert , Meindertsma Douwe , van der Linden Inge 
Published: October 2018

Beoordeling van datamacht in het mededingingstoezicht
Het gebruik van data levert belangrijke voordelen voor ondernemingen en consumenten. Het roept echter ook de maatschappelijke vraag op of verzameling en gebruik van data kunnen leiden tot marktmacht (‘datamacht’). Het risico daarop wordt bepaald door: (1) het belang van data als input, (2) de beschikbaarheid en repliceerbaarheid van data, (3) het belang van schaal- en netwerkeffecten en (4) de concurrentiesituatie op de markt waarvoor data een input vormen. Het mededingingstoezicht beschikt over de instrumenten om in specifieke situaties het ontstaan van datamacht als gevolg van concentraties te voorkomen en misbruik van datamacht te beëindigen of te bestraffen. Tot nu toe hebben die situaties zich in de praktijk nog weinig voorgedaan.
UN ADOLESCENT DANS LA PEAU D’UN AVATAR : ENJEUX DE LA RENCONTRE ENTRE LE PROCESSUS ADOLESCENT ET LES MONDES VIRTUELS
Authors: Vlachopoulou Xanthie , Missonnier Sylvain , Houssier Florian , Marty François 
Published: October 2018

Les perspectives inédites qu’inaugurent les réalités virtuelles trouvent chez les adolescents un public « captivé ». Parmi les hypothèses dynamiques que nous mettons au travail dans cet article en prenant appui sur un cas clinique, nous proposons que l’investissement massif de ce média peut avoir pour fonction l’évitement phobique de la pulsionnalité adolescente, évitement qui touche notamment la rencontre avec l’autre sexué. Cette fonction de l’évitement de l’autre interroge le processus adolescent dans son travail de transformation du sexuel infantile visant à trouver un objet sexuel non incestueux, sur fond de travail de subjectivation ouvrant sur le « devenir adulte ».
Le crossover en musique classique au Québec : portrait d’une pratique établie chez l’Orchestre symphonique de Québec
Authors: Trottier Laura 
Published: October 2018

Dans un contexte où le milieu de la musique classique semble affecté par la baisse de fréquentation d’un public large, certaines institutions musicales classiques développent différentes stratégies afin de conserver et de renouveler leur public. L’une de ces stratégies est le crossover, tel que pratiqué, entre autres, par l’Orchestre symphonique de Québec. Cette pratique, qui est maintenant établie au sein des programmations de concerts depuis plusieurs années, semble être devenue un moyen pour le public de renouer avec les institutions de musique classique. Le crossover chez les institutions symphoniques est-il seulement une stratégie marketing ? ou pourrait-il aussi suggérer une volonté de démocratisation culturelle de la part des institutions de musique classique comme l’Orchestre symphonique de Québec avec la société québécoise ? Actuellement au Québec, aucune recherche ne permet d’appréhender le phénomène au-delà de sa valeur commerciale afin de comprendre les implications socioculturelles de cette pratique. Cet article présente donc une analyse préliminaire de l’ensemble des programmations de concerts de l’Orchestre symphonique de Québec depuis la saison 2005–2006, qui a été effectuée afin de dresser un premier portrait de la situation. À la lumière des résultats suggérant que le crossover est maintenant une pratique établie chez l’Orchestre symphonique de Québec, il s’agit d’extraire les variantes et les constantes de la pratique et d’observer comment celle-ci aurait pu évoluer au fils des ans pour répondre aux goûts d’un public plus omnivore (Peterson, 1992). Cette analyse entre dans le cadre d’un projet de recherche plus vaste dont l’objectif est de mieux comprendre le phénomène du crossover au Québec et d’observer quel impact la diversification de l’offre de concerts a sur la démocratisation de la musique classique au Québec, en rapprochant les orchestres symphoniques et le public. Suite à cette recherche, nous serons en mesure de proposer des facteurs expliquant la présence marquée de concerts crossover en musique classique au Québec.
A Tribe Called Red’s Halluci Nation: Sonifying Embodied Global Allegiances, Decolonization, And Indigenous Activism
Authors: Woloshyn Alexa 
Published: October 2018

“We are the tribe that they cannot see. We live on an industrial reservation. We are the Halluci Nation.” These words from Indigenous activist and poet John Trudell (1946–2015) inspired the latest album by Ottawa-based Indigenous DJ collective A Tribe Called Red (ATCR) and frame its pan-Indigenous, transcultural message. Inter-tribal relationships are both common and important to Indigenous communities, especially in urban centres. Powwows are also events that emphasize intertribal and intercultural relationships, even as they hosted by a specific nation. WithHalluci Nation,ATCR seeks to foster far-reaching allegiances across culture, ethnicity, and place to “[understand] oppression and how to collectively dismantle oppression” (DJ NDN of ATCR).This article argues that ATCR’sHalluci Nationsonifies a process of decolonization that establishes an embodied network of global allies. I trace the development of ATCR’s music from its original focus on the Ottawa Indigenous community and its non-Indigenous allies to a call for nation-to-nation relationships (see Juno Award–winning albumNation II Nation,2013), and then now to a concept album that seeks to manifest a real “Halluci Nation” with members from around the world. Analysis of ATCR’s music, audience, andHalluci Nationalbum is contextualized by studies of community formation and identity politics in intertribal initiatives), such as powwows and friendship centres, and pan-Indigenous activism, such as Idle No More.
Midpregnancy Placental Growth Factor Screening and Early Preterm Birth
Authors: Gladstone Rachel A. , Ahmed Sumaiya , Huszti Ella , McLaughlin Kelsey , Snelgrove John W. , Taher Jennifer , Hobson Sebastian R. , Windrim Rory C. , Murphy Kellie E. , Kingdom John C. 
Published: November 2024

ImportanceEarly preterm birth (ie, at less than 34 weeks’ gestation) confers a high risk for adverse health outcomes, yet no universal screening strategy exists, preventing targeted delivery of effective interventions.ObjectiveTo evaluate the ability of midpregnancy placental growth factor (PlGF) screening to identify pregnancies at highest risk for early preterm birth.Design, Setting, and ParticipantsThis prospective cohort study was conducted at an urban, tertiary care center from 2020 to 2023. Participants were unselected, pregnant people with singleton pregnancies, receiving universal-access prenatal care from obstetricians, family physicians, or midwives, who underwent a PlGF test at the time of routine gestational diabetes screening, typically at 24 to 28 weeks’ gestation. Data were analyzed from January to May 2024.ExposurePlGF level less than 100 pg/mL at the time of gestational diabetes screen.Main Outcomes and MeasuresThe primary outcome was all early preterm birth, defined as less than 34 weeks’ gestation. Secondary outcomes included iatrogenic preterm birth, spontaneous preterm birth, preeclampsia, stillbirth, and small-for-gestational-age birth weight.ResultsAmong 9037 unique pregnant individuals, 156 (1.7%) experienced early preterm birth (52 spontaneous births; 104 iatrogenic births). The area under the curve (AUC) for PlGF and early preterm birth was 0.80 (95% CI, 0.75-0.85). Low PlGF level was associated with early preterm birth (positive likelihood ratio [LR], 79.400 [95% CI, 53.434-115.137]; negative LR, 0.606 [95% CI, 0.494-0.742]; specificity, 99.5% [95% CI, 99.3%-99.6%]; negative predictive value, 98.9% [95% CI, 98.8%-99.1%]). Time to birth from PlGF test was significantly reduced among patients with a PlGF level less than 100 pg/mL, among whom more than 50% delivered within 50 days of testing. Individuals with a low PlGF level made up more than 30% of subsequent stillbirths (aRR, 36.78 [95% CI, 18.63-72.60]) and more than half of patients requiring iatrogenic early preterm birth (aRR, 92.11 [95% CI, 64.83-130.87]). The AUC for iatrogenic early preterm birth was 0.90 (95% CI, 0.85-0.94).Conclusions and RelevanceThese findings suggest that low PlGF level (&amp;lt;100 pg/mL), identified at the time of routine gestational diabetes screening, may be a powerful clinical tool to identify pregnant people at risk of early preterm birth, especially in iatrogenic births. Strategic redirection of tertiary health care resources to this high-risk group could improve maternal and perinatal outcomes.