bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the impact of the self‐BAT screening tool on patient outcomes: Results of the let's talk period project
Authors: McDonald Laura , Grabell Julie , Leung Jennifer , Hopman Wilma , James Paula 
Published: November 2024

AbstractIntroductionOne of the many challenges in diagnosing bleeding disorders is distinguishing between normal and abnormal bleeding symptoms. Letstalkperiod.ca is an educational website that includes an online self‐administered bleeding assessment tool (Self‐BAT) which is a validated screening tool that enables patients to independently determine their bleeding scores (BS).AimThe aim of this study was to evaluate patient outcomes for those referred with an abnormal Self‐BAT BS compared to those referred without the prior use of the Self‐BAT.MethodsThis was a retrospective, observational study. After obtaining REB approval, chart review was performed for patients evaluated for a suspected bleeding disorder in a tertiary care centre between 2016 and 2023.Results351 patients (310 female) were identified for inclusion with a mean age of 41 years. Of these patients, 30 were referred for a positive/abnormal Self‐BAT BS and the remainder were referred for other reasons. Patients referred for a positive Self‐BAT BS required interventions for their bleeding symptoms more often (73.3% vs. 36.7%, p ≤ .001). Though they were not diagnosed with an inherited bleeding disorder more often (6.7% vs. 10.7%, p = .754), patients referred for a positive self‐BAT were more likely to be diagnosed with a bleeding disorder when the definition was expanded to include bleeding disorder of unknown cause (56.7% vs. 31.9%, p = .008).ConclusionResults of this study suggest that the Self‐BAT at letstalkperiod.ca can be a useful tool for patients and physicians to identify those needing referral to tertiary haematology clinics for evaluation and management of bleeding symptoms.
MANDATORY INTEGRATION AGREEMENTS FOR UNEMPLOYED JOB SEEKERS: A RANDOMIZED CONTROLLED FIELD EXPERIMENT IN GERMANY
Authors: van den Berg Gerard J. , Hofmann Barbara , Stephan Gesine , Uhlendorff Arne 
Published: November 2024

AbstractIntegration agreements (IAs) are contracts between the employment agency and the unemployed, nudging the latter to comply with rules on search behavior. We designed and implemented a randomized controlled trial involving thousands of newly unemployed workers, randomizing at the individual level both the timing of the IA and whether it is announced in advance. Administrative records provide outcomes. Novel theoretical and methodological insights provide tools to detect anticipation and suggest estimation by individual baseline employability. The positive effect on entering employment is driven by individuals with adverse prospects. For them, early IA increase reemployment within a year from 53% to 61%.
Navigating ethical considerations in the use of artificial intelligence for patient care: A systematic review
Authors: Badawy Walaa , Zinhom Haithm , Shaban Mostafa 
Published: November 2024

AbstractAimTo explore the ethical considerations and challenges faced by nursing professionals in integrating artificial intelligence (AI) into patient care.BackgroundAI's integration into nursing practice enhances clinical decision‐making and operational efficiency but raises ethical concerns regarding privacy, accountability, informed consent, and the preservation of human‐centered care.MethodsA systematic review was conducted, following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Thirteen studies were selected from databases including PubMed, Embase, IEEE Xplore, PsycINFO, and CINAHL. Thematic analysis identified key ethical themes related to AI use in nursing.ResultsThe review highlighted critical ethical challenges, such as data privacy and security, accountability for AI‐driven decisions, transparency in AI decision‐making, and maintaining the human touch in care. The findings underscore the importance of stakeholder engagement, continuous education for nurses, and robust governance frameworks to guide ethical AI implementation in nursing.DiscussionThe results align with existing literature on AI's ethical complexities in healthcare. Addressing these challenges requires strengthening nursing competencies in AI, advocating for patient‐centered AI design, and ensuring that AI integration upholds ethical standards.ConclusionAlthough AI offers significant benefits for nursing practice, it also introduces ethical challenges that must be carefully managed. Enhancing nursing education, promoting stakeholder engagement, and developing comprehensive policies are essential for ethically integrating AI into nursing.Implications for nursingAI can improve clinical decision‐making and efficiency, but nurses must actively preserve humanistic care aspects through ongoing education and involvement in AI governance.Implications for Health PolicyEstablish ethical frameworks and data protection policies tailored to AI in nursing. Support continuous professional development and allocate resources for the ethical integration of AI in healthcare.
Key phase diagram experiments and thermodynamic modeling of the ZnO‒B2O3, ZnO‒SiO2, and ZnO‒B2O3‒SiO2 systems
Authors: Kim Min‐Kyung , Lee Jaesung , Jung In‐Ho 
Published: November 2024

AbstractThermodynamic modeling of binary ZnO‒B2O3 and ZnO‒SiO2 systems and ternary ZnO‒B2O3‒SiO2 system were carried out based on the critical evaluation and optimization of all available phase diagram and thermodynamic property data using the CALculation of PHAse Diagram (CALPHAD) method. To resolve the inconsistency among the available phase diagram data in ternary ZnO‒B2O3‒SiO2 system, key phase diagram experiment was carried out using classical quenching method followed by electron probe micro‐analysis and X‐ray diffraction phase determination. The liquid oxide solution was described using the modified quasichemical model accounting for a short‐range ordering behavior in molten oxide solution. Thermodynamic models with optimized model parameters were used to predict the phase diagram and thermodynamic properties of the ternary systems.
The Impact of Product Packaging Characteristics on Order Picking Performance in Grocery Retailing
Authors: Loske Dominic , Mangiaracina Riccardo , Regattieri Alberto , Klumpp Matthias 
Published: November 2024

ABSTRACTIncreasing labor cost levels and workforce shortages have caused retailers to pay increased attention to their order‐fulfillment operations, which continue to largely depend on manual order picking systems. The operations and logistics management literature suggests that optimizing tertiary packaging, which groups products into full unit loads for storage and shipping, is an important way to improve order picking performance. While most retailers handle products at the level of secondary packaging when fulfilling orders, this packaging level remains largely unexplored. To address this gap, we analyze 3,380,596 picks performed by 185 order pickers of 4957 products in a grocery retail warehouse in Germany. Our findings indicate that secondary packaging characteristics directly affect order picking performance and that this effect is moderated by traditional product characteristics (e.g., product weight and volume), as well as elements of warehouse design (e.g., pick and stack levels). From a managerial perspective, our findings may help to bridge the gap between logistics managers and packaging engineers and provoke further research on the trade‐off between operational and environmental performance.
Rheumatoid Arthritis, Circulating Inflammatory Proteins, and Hypertension: A Mendelian Randomization Study
Authors: Jia Guobing , Guo Tao , Liu Lei , He Chengshi 
Published: November 2024

ABSTRACTObservational studies have indicated that there is an association between rheumatoid arthritis (RA) and an elevated risk of hypertension. However, a definitive causal relationship between the two conditions has not been established. The objective of this study was to investigate the causal link between RA and hypertension, as well as the potential mediating role of circulating inflammatory proteins in this relationship. We utilized Mendelian randomization (MR) to examine the causal relationship between RA and hypertension. The study data were obtained from publicly accessible genome‐wide association study (GWAS) databases and meta‐aggregates of large GWAS studies. The primary statistical method for determining causal effects was the inverse variance weighted (IVW) method, which was supplemented by a variety of sensitivity analyses. The results of the IVW method suggest a causal relationship between RA and an increased risk of hypertension (OR = 1.03, 95% CI = 1.01–1.04, p = 3.32 × 10−5). This association remained statistically significant even after adjusting for multiple confounding factors. Furthermore, MR analyses also revealed causal links between 10 circulating inflammatory proteins and the risk of hypertension, with TNF‐related activation‐induced cytokine partially mediating RA‐induced hypertension at a mediator ratio of 11.17% (0.27%–22.08%). Our study identifies causal relationships between several genetically determined inflammatory proteins and hypertension, establishing that RA increases hypertension risk, with inflammation partially mediating this effect. These findings provide new evidence supporting the inflammatory hypothesis in the mechanism of hypertension. Inflammatory factors may serve as potential targets for antihypertensive therapy.
Hypertension in Adults With Diabetes in Southeast Asia: A Systematic Review
Authors: Wong Wei Jin , Nguyen Tan Van , Ahmad Fahed , Vu Huyen Thi Thanh , Koh Angela S. , Tan Kit Mun , Zhang Ying , Harrison Christopher , Woodward Mark , Nguyen Tu Ngoc 
Published: November 2024

ABSTRACTDiabetes is one of the most pressing health issues in the Southeast Asian region, and hypertension has been commonly reported as a comorbidity in adults with diabetes. This systematic review aimed to synthesize evidence on the prevalence and management of hypertension in adults with diabetes in Southeast Asian countries. A literature search was conducted in Ovid MEDLINE and Embase Classic + Embase from database inception until March 15, 2024. Studies were included if (1) they were conducted in Southeast Asian countries, (2) the study populations were adults with diabetes, and (3) there was information related to hypertension or blood pressure (BP) in the study results. Of the 7486 abstracts found, 90 studies qualified for this review. Most studies reported a hypertension prevalence of 70% or higher (ranging from 29.4% to 93.4%). Despite this high prevalence, a substantial proportion of these populations did not receive adequate BP control, with most studies indicating a control rate of less than 40%. There was limited evidence on the prescription of antihypertensive therapies and medication adherence. There was a lack of studies from 4 of the 11 countries in the region. This review highlights that BP control in adults with diabetes remains a significant challenge in Southeast Asia. Given the ongoing epidemiological transition, and the increasing older population in this region who are likely to accumulate multiple chronic conditions complicating medication strategies, this review highlights the urgent need to improve BP management in those with diabetes.
Resolving the problem of surface dyslexia in Italian through inflection of irregular verbs
Authors: Licciardo Daniele , Isella Valeria , Canu Elisa , Forestiero Marta , Castelnovo Veronica , Valsecchi Stefania , Agosta Federica , Filippi Massimo , Appollonio Ildebrando , Nestor Peter J 
Published: November 2024

AbstractSurface dyslexia and dysgraphia are considered diagnostic features of semantic variant primary progressive aphasia (svPPA) and are useful signs in English, a language whose attributes afford numerous opportunities to observe these phenomena. This, however, is not the case in many languages, including Italian, that have high transparency between orthography and phonology, making surface reading and spelling errors scarce. This creates a problem in applying the diagnostic recommendations for svPPA in such languages. Surface dyslexia and dysgraphia are examples of ‘regularization’ errors in which semantic knowledge loss leads to a failure to recognize exceptions that do not follow standard rules of pronunciation. Another form of regularization involves the incorrect inflection of irregular verbs using the rules that govern regular verbs. Unlike irregularly pronounced words, Italian, as with many languages, has numerous irregular verbs. The Italian Verb Inflection Test (IVIT) was developed to test the hypothesis that svPPA would regularize irregular verbs when inflecting them into two Italian past tenses. Results confirmed that people with svPPA made a significantly greater proportion of regularization errors compared to people with typical Alzheimer's disease or logopenic variant PPA. Without recourse to the other diagnostic features of PPA subgroups, the IVIT on its own could separate svPPA from these other two groups with 70% sensitivity and ~ 80% specificity. Regularization of irregular verb inflection offers a solution to the problem of applying the surface dyslexia/dysgraphia criterion for svPPA diagnosis in Italian.
Effect of vitamin D adjuvant therapy on the proportion of regulatory T cells in peripheral blood and pregnancy outcome of patients with recurrent miscarriage
Authors: Ling Shaoyun 
Published: November 2024

AbstractBackgroundRecurrent miscarriage (RM) is influenced by immune factors, particularly regulatory T cells, which can impact immune function and miscarriage risk. Vitamin D (VD) is known to regulate the immune system, potentially improving pregnancy outcomes in RM patients. This study aims to assess the effect of VD adjuvant therapy on regulatory T cells and pregnancy outcomes in RM patients.MethodsClinical data from 104 individuals with RM admitted to our hospital between March 2022 and February 2023 were allocated at random to either the VD group (VDG) or the control group (CG), with 52 patients in each group. Both groups received standard treatment; the CG was treated with aspirin, while the VDG received additional VD therapy. Outcomes measured included regulatory T cell proportion, metabolic factors, immune inflammatory markers, and pregnancy outcomes.ResultsAfter treatment, the proportion of regulatory T cells in VDG was considerably higher (p < 0.05). Additionally, triglyceride levels, leptin, fasting blood glucose, and fasting insulin were lower in the VDG, whereas adiponectin levels were higher (p < 0.05). Levels of progesterone, luteinizing hormone, and 25‐hydroxy VD were also higher in the VDG (p < 0.05). Furthermore, interleukin‐17, gamma interferon, tumor necrosis factor‐α, and C‐reactive protein were lower in the VDG (p < 0.05). The pregnancy success rate in the VDG was higher, and the preterm birth rate was lower (p < 0.05).ConclusionAdjuvant treatment with VD can increase the proportion of regulatory T cells in peripheral blood of individuals with recurrent abortion, regulate metabolic disorder, alleviate immune inflammation, and improve pregnancy outcome.
Factors Associated with Mental Health Care among Adolescents in Southern California
Authors: Rivas Gisselle Soto , Canady Margaret , Klemm Gina , Barrington‐Trimis Jessica L. , Harlow Alyssa F. 
Published: November 2024

ABSTRACTBACKGROUNDMental health care is critical to improving mental health but factors associated with student utilization are poorly understood.METHODSData were from high school students (N = 2933; mean age = 15.7 ± .6) enrolled in a California cohort. We examined associations of sociodemographic factors, substance use, and mental health symptoms at baseline (Fall 2021) with mental health care at follow‐up (Spring 2022).RESULTSAt follow‐up, 7.7% of students reported out‐of‐school therapy, and 16.0% reported in‐school counseling. Generally, therapy was more common for female and gender minority (vs male), some sexual minority youth (vs heterosexual), black, non‐Hispanic white, and multi‐ethnic (vs Asian), and English language speakers. Higher socioeconomic status was associated with greater use of out‐of‐school therapy, but not in‐school counseling. Students with clinical levels of mental health symptoms, or alcohol or e‐cigarette use had greater odds of mental health care (ORs = 1.42‐2.61;ps <.05), though utilization was less than 20% for out‐of‐school therapy and less than 30% for in‐school counseling among these students.CONCLUSIONSMental health care is underutilized, and disproportionately used by certain student sub‐groups. Findings indicate a need to increase mental health care utilization in‐ and out‐of‐school.
The impact of a 20‐h rotating watch schedule on cognitive and mood states in submarine operations
Authors: Erez David , Lieberman Harris R. , Rafael Nadav , Ketko Itay , Moran Daniel S. 
Published: November 2024

SummaryThis is the first study to provide valuable insights into the effects of the Israeli Navy's 20‐h rotating watch schedule on submariners’ alertness, mood states, risk‐taking behaviours, and sleep. Specifically, we assessed the impact of the non‐circadian‐aligned schedule on cognitive performance, mood, and behavioural outcomes in a highly controlled submarine environment. A total of 20 male submariners participated in an at‐sea mission, where their cognitive performance, mood states, risk‐taking propensity, and caffeine consumption were measured. A psychomotor vigilance task (PVT) assessed alertness, the propensity for risky behaviour (Evaluation of Risks Scale) measured risk‐taking behaviours, and the Profile of Mood States evaluated mood disturbances. Actigraphy was used to monitor sleep times. Data were analysed according to seven watch schedule segments. Submariners slept a mean (standard error of the mean [SEM]) of 8.3 (0.2) h/24 h, fragmented into 3.7 (0.8) h epochs. Caffeine consumption decreased at sea (mean [SEM] 149.3 [6.0] mg) compared to land (mean [SEM] 205.5 [7.2] mg; p = 0.027). In the PVT, premature responses significantly increased during Watch VI (5:00–8:00 p.m.) and Watch VII (8:00 p.m.–12:00 a.m.; p = 0.014). In the mood subscales, tension was significantly higher during Watch II (4:00–8:00 a.m.; p = 0.002), indicating greater stress. Risk‐taking propensity significantly increased during afternoon shifts (p = 0.050). The 20‐h watch schedule led to fragmented sleep, reduced alertness in the evening, worsened mood states in the early morning, and increased risk‐taking propensity in the afternoon. These findings suggest the need for the Israeli Navy to establish evidence‐based caffeine guidelines and optimise the watch schedule to improve submariners’ sleep, performance, and overall well‐being.
Evaluation of laboratory findings indicating pancreatitis in healthy lean, obese, and diabetic cats
Authors: Jørgensen Freja K. , Bjornvad Charlotte R. , Krabbe Birgit , Nybroe Stinna , Kieler Ida N. 
Published: November 2024

AbstractBackgroundObesity is a risk factor for diabetes mellitus, which commonly coexists with pancreatitis in cats. However, obesity has not previously been associated with pancreatitis in cats.ObjectivesTo evaluate factors affecting serum concentrations of pancreatic lipase immunoreactivity (fPLI), trypsin‐like immunoreactivity (fTLI), cobalamin and folate in clinically healthy lean, overweight and obese, or diabetic cats.AnimalsSeventy‐nine client‐owned cats (27 healthy lean [LN, BCS 4‐5/9], 30 healthy overweight and obese [OW, BCS 7‐9/9], and 22 diabetic [DM]) were included.MethodsCross‐sectional study. The cats underwent physical examination, and blood tests. Linear regression models compared differences in fPLI, fTLI, cobalamin, and folate concentrations. Fisher's exact test assessed the proportions of cats with fPLI and fTLI indicative of pancreatitis, and hypocobalaminemia. A random forest algorithm identified explanatory variables for cats having fPLI levels indicative of pancreatitis.ResultsNo LN cats, while 6/30 (20%) of OW and 10/22 (45%) of DM cats had fPLI concentrations indicative of pancreatitis. Body condition score (P = .02) and body weight (P = .002) were positively associated with fPLI levels in LN and OW cats. Higher fPLI, and lower cobalamin concentrations were associated with higher age across groups.Conclusions and Clinical ImportanceBody condition score and body weight were associated with higher fPLI levels in nondiabetic cats. A larger proportion of OW and DM cats had fPLI concentrations indicative of pancreatitis compared to LN cats. Whether this indicates subclinical pancreatitis remains to be determined. Hypocobalaminemia was less frequent in OW compared to DM cats.
Secondary contact erodes Pleistocene diversification in a wide‐ranging freshwater mussel (Quadrula)
Authors: Keogh Sean M. , Johnson Nathan A. , Smith Chase H. , Sietman Bernard E. , Garner Jeffrey T. , Randklev Charles R. , Simons Andrew M. 
Published: November 2024

ABSTRACTThe isolated river drainages of eastern North America serve as a natural laboratory to investigate the roles of allopatry and secondary contact in the evolutionary trajectories of recently diverged lineages. Drainage divides facilitate allopatric speciation, but due to their sensitivity to climatic and geomorphological changes, neighboring rivers frequently coalesce, creating recurrent opportunities of isolation and contact throughout the history of aquatic lineages. The freshwater mussel Quadrula quadrula is widely distributed across isolated rivers of eastern North America and possesses high phenotypic and molecular variation across its range. We integrate sequence data from three genomes, including female‐ and male‐inherited mitochondrial markers and thousands of nuclear encoded SNPs with morphology and geography to illuminate the group's divergence history. Across contemporary isolated rivers, we found continuums of molecular and morphological variation, following a pattern of isolation by distance. In contact zones, hybridization was frequent with no apparent fitness consequences, as advanced hybrids were common. Accordingly, we recognize Q. quadrula as a single cohesive species with subspecific variation (Q. quadrula rumphiana). Demographic modeling and divergence dating supported a divergence history characterized by allopatric vicariance followed by secondary contact, likely driven by river rearrangements and Pleistocene glacial cycles. Despite clinal range‐wide variation and hybridization in contact zones, the process‐based species delimitation tool delimitR, which considers demographic scenarios like secondary contact, supported the delimitation of the maximum number of species tested. As such, when interpreting species delimitation results, we suggest careful consideration of spatial sampling and subsequent geographic patterns of biological variation, particularly for wide‐ranging taxa.