bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metallopanstimulin-1 (MPS-1) mediates the promotion effect of leptin on colorectal cancer through activation of JNK/c-Jun signaling pathway
Authors: Cao Dongxing , Luo Yang , Qin Shaolan , Yu Minhao , Mu Yifei , Ye Guangyao , Yang Nailin , Cong Zhijie , Chen Jianjun , Qin Jun , Cui Ran , Jing Ran , Cao Hui , Zhong Ming 
Published: September 2019

AbstractObesity is a major epigenetic cause for colorectal cancer (CRC). Leptin is implicated in obesity-associated CRC, but the underlying mechanism remains unclear. The current study identified over-expression of metallopanstimulin-1 (MPS-1) in CRC patients through microarray and histological analysis, especially in obese CRC patients. MPS-1 was correlated with advanced tumor stage, suggesting its association with CRC progression. In addition, MPS-1 over-expression was associated with poor overall survival (OS) in obese CRC patients, but not in their non-obese counterparts, suggesting its potential as a prognostic marker of obese CRC patients. MPS-1 expression was positively associated with circulating leptin levels in CRC patients, especially in obese cases. Functional experiments demonstrated that MPS-1 silencing inhibited tumor proliferation and colony formation, and induced apoptosis of CRC cells in vitro. Converse results were obtained from the experiments with MPS-1 over-expression. Mechanistically, MPS-1 executed its action through induction of c-Jun N-terminal kinase (JNK)/c-Jun pathway. Moreover, the promotion effect of MPS-1 on CRC progression was modulated by leptin. In vivo studies demonstrated that MPS-1 silencing suppressed tumor growth of CRC via inhibiting JNK/c-Jun signaling. Collectively, this study indicates that MPS-1 promotes leptin-induced CRC via activating JNK/c-Jun pathway. MPS-1 might represent a potent candidate for the treatment and prognostic prediction of obesity-associated CRC.
Distinct forms of motion sensitivity impairments in Alzheimer’s disease
Authors: Liu Yining , Feng Depeng , Wang Hui 
Published: September 2019

AbstractMotion sensitivity impairment in Alzheimer’s disease (AD) is often characterized as elevated coherence threshold. An alternative way to measure motion sensitivity is the direction threshold, i.e., the minimal angle of motion direction that can be discriminated. So far, it is less clear whether and how the direction threshold is altered in AD. Here we asked a group of AD patients and two control groups of healthy participants (young and elderly adults) to judge their perceived heading direction based on a field of optic flow stimuli simulating a forward translation in the environment. We manipulated the heading direction and the coherence of the optic flow independently and measured the direction and coherence thresholds from each participant. We found that the direction threshold increased significantly in AD patients as compared to healthy controls, like the coherence threshold. Yet, the elevation in the direction threshold was less pronounced than the coherence threshold. Moreover, the magnitudes of the direction and coherence thresholds in AD patients were not correlated. Our results suggest that coherence and direction impairments are two distinct forms of motion deficits in AD patients which might be associated with independent neural mechanisms.
Whole genome sequence analysis reveals high genetic variation of newly isolated Acidithiobacillus ferrooxidans IO-2C
Authors: Fariq Anila , Blazier John C. , Yasmin Azra , Gentry Terry J. , Deng Youjun 
Published: September 2019

AbstractAcidithiobacillus ferrooxidans, a chemolithoautotrophic bacterium, is well known for its mineral oxidizing properties. The current study combines experimental and whole genome sequencing approaches to investigate an iron oxidizing, extreme acidophilic bacterium, A. ferrooxidans isolate (IO-2C) from an acid seep area near Carlos, TX, USA. Strain IO-2C was capable of oxidizing iron i.e. iron sulphate and iron ammonium sulphate yielding shwertmannite and jarosite minerals. Further, the bacterium’s genome was sequenced, assembled and annotated to study its general features, structure and functions. To determine genetic heterogeneity, it was compared with the genomes of other published A. ferrooxidans strains. Pan-genome analysis displayed low gene conservation and significant genetic diversity in A. ferrooxidans species comprising of 6926 protein coding sequences with 23.04% (1596) core genes, 46.13% (3195) unique and 30.82% (2135) accessory genes. Variant analysis showed >75,000 variants, 287 of them with a predicted high impact, in A. ferrooxidans IO-2C genome compared to the reference strain, resulting in abandonment of some important functional key genes. The genome contains numerous functional genes for iron and sulphur metabolism, nitrogen fixation, secondary metabolites, degradation of aromatic compounds, and multidrug and heavy metal resistance. This study demonstrated the bio-oxidation of iron by newly isolated A. ferrooxidans IO-2C under acidic conditions, which was further supported by genomic analysis. Genomic analysis of this strain provided valuable information about the complement of genes responsible for the utilization of iron and tolerance of other metals.
MARK4 protein can explore the active-like conformations in its non-phosphorylated state
Authors: Ahrari Sajjad , Khosravi Fatemeh , Osouli Ali , Sakhteman Amirhossein , Nematollahi Alireza , Ghasemi Younes , Savardashtaki Amir 
Published: September 2019

AbstractMicrotubule affinity-regulating kinase 4 (MARK4) is a Ser/Thr protein kinase, best known for its role in phosphorylating microtubule associated proteins, causing their detachment from microtubules. In the current study, the non-phosphorylated conformation of the activation loop was modeled in a structure representing the enzymatically inactive form of this protein, and its dynamics were evaluated through a 100 ns initial all-atom simulation, which was prolonged by another 2 μs. Although the activation loop was folding on itself and was leaning toward ATP site in the initial modeled structure, soon after the initiating the simulation, this loop stretched away from the ATP binding site and stably settled in its new position for the rest of simulation time. A network of hydrogen bonds, mainly between the activation segment residues, αC-helix and the catalytic loop reinforced this conformation. Interestingly, several features of active kinase conformation such as formation of R-spine, Glu106-Lys88 salt-bridge, and DFG-In motif were observed during a considerable number of trajectory frames. However, they were not sustainably established during the simulation time, except for the DFG-In motif. Consequently, this study introduces a stable conformation of the non-phosphorylated form of MARK4 protein with a partially stretched activation loop conformation as well as partial formation of R-spine, closely resembling the active kinase.
Arsenic mobilization in a high arsenic groundwater revealed by metagenomic and Geochip analyses
Authors: Jiang Zhou , Li Ping , Wang Yanhong , Liu Han , Wei Dazhun , Yuan Changguo , Wang Helin 
Published: September 2019

AbstractMicrobial metabolisms of arsenic, iron, sulfur, nitrogen and organic matter play important roles in arsenic mobilization in aquifer. In this study, microbial community composition and functional potentials in a high arsenic groundwater were investigated using integrated techniques of RNA- and DNA-based 16S rRNA gene sequencing, metagenomic sequencing and functional gene arrays. 16S rRNA gene sequencing showed the sample was dominated by members ofProteobacteria(62.3–75.2%), such as genera ofSimplicispira(5.7–6.7%),Pseudomonas(3.3–5.7%),Ferribacterium(1.6–4.4%),Solimonas(1.8–3.2%),Geobacter(0.8–2.2%) andSediminibacterium(0.6–2.4%). Functional potential analyses indicated that organics degradation, assimilatory sulfate reduction, As-resistant pathway, iron reduction, ammonification, nitrogen fixation, denitrification and dissimilatory nitrate reduction to ammonia were prevalent. The composition and function of microbial community and reconstructed genome bins suggest that high level of arsenite in the groundwater may be attributed to arsenate release from iron oxides reductive dissolution by the iron-reducing bacteria, and subsequent arsenate reduction by ammonia-producing bacteria featuringarsoperon. This study highlights the relationship between biogeochemical cycling of arsenic and nitrogen in groundwater, which potentially occur in other aquifers with high levels of ammonia and arsenic.
Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis
Authors: Horii Takeshi , Iwasawa Makiko , Kabeya Yusuke , Atuda Koichiro 
Published: September 2019

AbstractPolypharmacy (PP) occurs in patients with type 2 diabetes (T2DM) owing to multimorbidity. We evaluated concomitant PP and medication adherence in T2DM 3 years after initiation of administration of a hypoglycaemic agent using a nationwide claim-based database in Japan. Factors associated with medication PP and imperfect adherence were identified using multivariable logistic regression. PP was defined as using ≥6 medications. Patients with proportion of days covered (PDC) of <80% were defined as having poor medication adherence. A total of 884 patients were analysed. Multivariate analysis revealed that age, total number of consultations and body mass index (BMI) are factors that influence PP. Factors associated with PDC < 80% were 2–3, 4–5 and ≥ 6 medications compared with 1 medication, male sex, <17 consultations and age 50–59 and ≥ 60 years compared with <40 years. In conclusion, older age, high total number of consultations and BMI ≥ 25 kg/m2 are risk factors for PP. PP influenced good medication adherence at the end of the observation period.
Midfrontal neural dynamics distinguish between general control and inhibition-specific processes in the stopping of motor actions
Authors: Kaiser Jakob , Simon Natalie Annette , Sauseng Paul , Schütz-Bosbach Simone 
Published: September 2019

AbstractAction inhibition, the suppression of action impulses, is crucial for goal-directed behaviour. In order to dissociate neural mechanisms specific to motor stopping from general control processes which are also relevant for other types of conflict adjustments, we compared midfrontal oscillatory activity in human volunteers via EEG between action inhibition and two other types of motor conflicts, unexpected action activation and unexpected action change. Error rates indicated that action activation was significantly easier than the other two equally demanding tasks. Midfrontal brain oscillations were significantly stronger for inhibition than for both other conflict types. This was driven by increases in the delta range (2–3 Hz), which were higher for inhibition than activation and action change. Increases in the theta range (4–7 Hz) were equally high for inhibition and change, but lower for action activation. These findings suggest that inhibition is facilitated by neural mechanisms specific to motor-stopping, with midfrontal delta being a potentially selective marker of motor inhibition.
Chemokines as the modulators of endometrial epithelial cells remodelling
Authors: Złotkowska A , Andronowska A 
Published: September 2019

AbstractPrevious studies highlighted chemokines as potential factors regulating changes in the endometrium during early pregnancy. The current study aimed to screen the effects of a broad range of chemokines and indicate those that are involved in porcine luminal epithelial (LE) cell remodelling. Messenger RNA expression of chemokines (CCL2, CCL4, CCL5, CCL8, CXCL2, CXCL8, CXCL10 and CXCL12) and both the mRNA and protein expression of their receptors (CCR1, CCR2, CCR3, CCR5, CXCR2, CXCR3, CXCR4) were detected in LE cells. Exogenous CCL8 enhanced the proliferative and migration potential of LE cells and their motility in the environment with its stable concentration. The adhesive properties of LE cells were negatively affected by CCL8. However, CXCL12 positively affected the proliferation, motility and adhesion of LE cells as well as caused a decrease in MUC1 mRNA expression. To conclude, our studies determined that exogenous chemokines affected critical endometrial epithelial cell functions in the context of embryo implantation. We suggest that of all the examined factors, chemokine CCL8 participates in the establishment of a proper environment for embryo implantation, whereas CXCL12, apart from participation in endometrial receptivity, promotes embryo attachment.
Photon-Assisted Perfect Conductivity Between Arrays of Two-Level Atoms
Authors: Chang Chih-Chun , Lin Lee , Chen Guang-Yin 
Published: September 2019

AbstractWe investigate interactions between two (parallel) arrays of two-level atoms (2LA) via photons through quantum electrodynamical interaction with one array (the source array) connected to a particle source, and we study the (photo-)resistivity of the other array (the measured array). The wave function of the interacted photon propagating in an array is a Bloch wave with a gap in its eigenvalue (the photonic dispersion). Due to interactions between arrayed 2LA and the dressed photonic field with non-linear dispersion, the conduction behaviors of the measured array can be very diversified according to the input energy of the particle source connected to the source array, and their relative positions. As a result, the resistivity of the measured array can be zero or negative, and can also be oscillatory with respect to the incoming energy of the particle source of the source array, and the separation between arrays.
High-accuracy bulk electronic bandmapping with eliminated diffraction effects using hard X-ray photoelectron momentum microscopy
Authors: Babenkov S. , Medjanik K. , Vasilyev D. , Chernov S. , Schlueter C. , Gloskovskii A. , Matveyev Yu. , Drube W. , Schönhense B. , Rossnagel K. , Elmers H.-J. , Schönhense G. 
Published: September 2019

AbstractA key benefit of angle-resolved photoelectron spectroscopy (ARPES) in the X-ray range is the significant increase of the information depth, thanks to the large inelastic mean-free-path of the escaping photoelectrons. In practice hard X-ray ARPES (HARPES) faces severe challenges by low cross sections, large photon momentum transfer, and in particular strong phonon scattering and photoelectron diffraction effects. Here, we show that these challenges can be overcome by extending ultra-efficient time-of-flight momentum microscopy into the hard X-ray regime. Phonon scattering destroys the initial momentum distribution but subsequent diffraction at the lattice imprints a pronounced Kikuchi-type pattern on the background signal. Moreover, the pattern of the valence electrons is modulated by diffraction as well. For the examples of the medium-weight element materials Mo and layered TiTe2, we demonstrate how comprehensive valence-band and core-level photoemission data taken under identical conditions can be used to effectively remove photoelectron diffraction effects in HARPES band maps.
Sprechstimmprofil depressiver Störungen im Kindesalter und ihre Bedeutung für die Diagnostik in der Kinder- und Jugendpsychiatrie und -psychotherapie. Eine empirische Studie
Authors: Stang Philipp , Schleider Karin , Reimann Sandra 
Published: September 2019

Zusammenfassung
Hintergrund Analysen von Sprechstimmprofilen depressiver Kinder weisen spezifische sprechstimmliche Merkmale auf und können einen wichtigen Beitrag zur Diagnostik leisten.
Methode Es handelt sich um eine quasiexperimentelle Studie im Querschnittdesign zum Vergleich ausgewählter Faktoren der Sprechstimme depressiver und gesunder Kinder. 2018 wurden zwei Stichproben untersucht und jeweils Sprechstimmprofile erstellt.
Ergebnisse Es ergeben sich Unterschiede in den stimmlichen Parametern zwischen Kindern mit und ohne eine depressive Störung, welche sich in Teilen von den Ergebnissen erwachsener Sprecher unterscheiden.
Diskussion Es scheint nun möglich, über eine Sprechstimmanalyse einen Beitrag zur Verbesserung der Diagnostik von depressiven Störungen zu leisten.
Total Hip Arthroplasty in Patients with Coagulopathy
Authors: von Roth Philipp , Thiele Kathi 
Published: September 2019

AbstractPrior to a surgical intervention, the examination of patient coagulation disorders is unfortunately often underestimated. While patients with a haemophilia A or B are usually aware of the congenital tendency to bleed, disorders of increased blood coagulation, thrombophilia, are frequently undetected. Therefore, complications caused by thromboses and embolisms after total hip arthroplasty are far more common than uncontrollable post-operative bleeding. Patients with liver cirrhosis are considered to be particularly complicated and their coagulation status can be difficult to manage. This article describes the most common pathological coagulation disorders and provides information to identify them preoperatively. Furthermore, surgical strategy considerations for the use of certain implant types in this patient group are discussed.
Total Hip Arthroplasty in Young and Obese Patients
Authors: Matziolis Georg , Brodt Steffen 
Published: September 2019

AbstractSpecial attention should be drawn on endoprosthetic hip replacement in young and obese patients because of an increased risk of perioperative complications and early implant failure. Gain of function and reduction of pain are not compromised in these patients, so that the indication criteria remain unchanged. Implant survival is reduced in very young patients and mainly influenced by the bearing materials. The risk of implant malalignment, specifically of the cup, can be minimized by an intraoperative X-ray control. The effect of bariatric surgery on perioperative complications remains unclear. But a preoperatively uncontrolled diabetes increases the risk of infection. Known specific risk factors of young and obese patients should be considered during the perioperative management and be included in the individual operation planning and informed consent.
Optimising Results of Nasal Tip Rotation Applying Combination of Nasolabial Angle and Lip–Columellar Angle in Tandem in Patients Operated by “Cock-up” Alar Cartilage Flaps Technique
Authors: Bhat Uday , Peswani Amit Ratanlal , Wagh Snehjeet , Mishra Rohit , Gupta Tarush , Baliarsing Amresh 
Published: September 2019

Abstract
Background Setting the angle of tip rotation is of utmost importance in achieving satisfactory results in rhinoplasty. Conventionally the upward rotation of the tip requires shortening of the septum by caudal resection and shortening of the lateral walls by cephalic trim of the alar cartilages. The results are usually assessed subjectively. We describe the use of objective parameters to ensure accuracy of nasal tip rotation in patients operated with “cock-up” alar cartilage flaps, a modification of the cephalic trim.
Methods Fifteen patients with a long nose having adequate width of lateral crura, desiring a shorter nose with upward tip rotation, were included in the study. Values of preoperative and desired nasolabial angle (from morphed images), and the derived columellar–labial angle were documented. Nasal tip rotation was set to the derived angle and maintained using cock-up alar cartilage flaps. The outcome was evaluated by digital measurements of the nasolabial angle and patients’ feedback by Rhinoplasty Outcome Evaluation (ROE) score.
Results Satisfactory tip rotation and an aesthetic supratip area could be achieved. The difference in preoperative and postoperative nasolabial angles was statistically significant (p value < 0.0001). The difference in desired and the obtained nasolabial angle was not significant (p value 0.085). The results were maintained on subsequent follow-up.
Conclusion Application of angles in practice and use of K-wire template helps us achieve accurate and consistent results. Cock-up flap is an effective technique—to obtain an open nasolabial angle and a desirable supratip region by making use of tissues otherwise discarded.
Efficacy of Periconceptional High-Dose Folic Acid in Isolated Orofacial Cleft Prevention: A Systematic Review
Authors: Jayarajan Rajshree , Natarajan Anantharajan , Nagamuttu Ravindranathan 
Published: September 2019

Abstract
Background The effectiveness of folic acid in prevention of neural tube defects has been well established. Periconceptional supplementation of folic acid in low doses has been shown to be effective in some studies on its efficacy in prevention of occurrence of clefts. There are few studies on high-dose folic acid for prevention of occurrence and recurrence of clefts in high risk cases and the overall consensus based on these is not available.
Objectives The aim of this review is to assess whether high-dose folic acid supplementation during the periconceptional period reduces the risk of occurrence of nonsyndromic clefts and recurrence in high-risk cases.
Search Methods Search was conducted in the various databases and trial registers. There were no restrictions in the search with regards to language, study setting, or date of publication.
Results The search yielded four studies—one randomized control trial, two prospective control trials, and a case–control surveillance on screening 401 articles. The three case–control studies were specifically on recurrence of clefts in high risk cases. The heterogeneity of the studies prevented conduction of a meta-analysis. But results of the studies demonstrate a strong association between high-dose folic acid and isolated nonsyndromic cleft lip with or without cleft palate (CL±CP). But such an effect is weak with regards to isolated cleft palate (CP).
Conclusions With the limited evidence available, our conclusion is that high-dose folic acid probably has a role in prevention of recurrence of isolated CL±CP in high-risk individuals, but not CP.
A safe and sustainable bacterial cellulose nanofiber separator for lithium rechargeable batteries
Authors: Gwon Hyeokjo , Park Kitae , Chung Soon-Chun , Kim Ryoung-Hee , Kang Jin Kyu , Ji Sang Min , Kim Nag-Jong , Lee Sunghaeng , Ku Jun-Hwan , Do Eun Cheol , Park Sujin , Kim Minsang , Shim Woo Yong , Rhee Hong Soon , Kim Jae-Young , Kim Jieun , Kim Tae Yong , Yamaguchi Yoshitaka , Iwamuro Ryo , Saito Shunsuke , Kim Gahee , Jung In-Sun , Park Hyokeun , Lee Chanhee , Lee Seungyeon , Jeon Woo Sung , Jang Woo Dae , Kim Hyun Uk , Lee Sang Yup , Im Dongmin , Doo Seok-Gwang , Lee Sang Yoon , Lee Hyun Chul , Park Jin Hwan 
Published: September 2019

Significance
This report describes an opportunity for the bacterial cellulose nanofiber (BCNF) membrane, which has recently been attracting much attention due to its sustainability and high thermal stability, as a “single-layer,” good alternative membrane to the existing chemical-derived one in batteries, and thus allows us to find possible solutions to the environmental and safety issues. We achieved highest BCNF yield ever reported so far and fabricated a cylindrical lithium ion battery (LIB) by roll-to-roll process to realize remarkable cycle stability with 80% capacity retention even after 1,000 cycles, which is comparable to those of commercialized batteries. Finally, we introduced a Lewis base to improve thermal safety of the battery to a level comparable to that of a commercial ceramic-coated separator.