bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐similarity measurement driven ensemble just‐in‐time learning for soft sensing of industrial processes
Authors: Yuan Xiaofeng , Zhou Jiao , Wang Yalin , Yang Chunhua 
Published: May 2018

AbstractJust‐in‐time learning (JITL) technique has been widely used for adaptive soft sensing of nonlinear processes. It builds online local model with the most relevant samples from historical dataset whenever a query sample comes. Hence, the prediction performance greatly depends on the similarity measurement for relevant sample selection. Different similarity measurements have been developed for sample selection in the past decades. However, each method only focuses on one aspect of sample similarity and has its own limitations. Moreover, it is difficult to obtain the similarity mechanism of real process data. A single similarity measurement does not always provide satisfactory prediction performance. To deal with this problem, a novel ensemble just‐in‐time learning (E‐JITL) framework is proposed in this paper. In E‐JITL, different similarity measurements are adopted for sample selection. Then, local prediction models are constructed and trained to estimate the output of the query data with different groups of relevant samples corresponding to the similarity measurements. At last, a final prediction can be obtained by an ensemble strategy on each local model. The effectiveness of the E‐JITL is validated on two industrial applications.
Monitoring the Hydrothermal Growth of Cobalt Spinel Water Oxidation Catalysts: From Preparative History to Catalytic Activity
Authors: Reith Lukas , Lienau Karla , Cook Daniel S. , Moré René , Walton Richard I. , Patzke Greta R. 
Published: May 2018

AbstractThe hydrothermal growth of cobalt oxide spinel (Co3O4) nanocrystals from cobalt acetate precursors was monitored with in situ powder X‐ray diffraction (PXRD) in combination with ex situ electron microscopy and vibrational spectroscopy. Kinetic data from in situ PXRD monitoring were analyzed using Sharp–Hancock and Gualtieri approaches, which both clearly indicate a change of the growth mechanism for reaction temperatures above 185 °C. This mechanistic transition goes hand in hand with morphology changes that notably influence the photocatalytic oxygen evolution activity. Complementary quenching investigations of conventional hydrothermal Co3O4 growth demonstrate that these insights derived from in situ PXRD data provide valuable synthetic guidelines for water oxidation catalyst production. Furthermore, the ex situ analyses of hydrothermal quenching experiments were essential to assess the influence of amorphous cobalt‐containing phases arising from the acetate precursor on the catalytic activity. Thereby, the efficient combination of a single in situ technique with ex situ analyses paves the way to optimize parameter‐sensitive hydrothermal production processes of key energy materials.
2‐Benzoylpyridine Ligand Complexation with Gold Critical for Propargyl Ester‐Based Protein Labeling
Authors: Lin Yixuan , Vong Kenward , Matsuoka Koji , Tanaka Katsunori 
Published: May 2018

AbstractIn previously reported work, AuIII complexes coordinated with 2‐benzoylpyridine ligand, BPy‐Au, were prebound to a protein and used to discover a novel protein‐directed labeling approach with propargyl ester functional groups. In this work, further examination discovered that gold catalysts devoid of the 2‐benzoylpyridine ligand (e.g., NaAuCl4) had significantly reduced levels of protein labeling. Mechanistic investigations then revealed that BPy‐Au and propargyl esters undergo a rare example of C(sp2)−C(sp) aryl–alkynyl cross‐coupling, likely through spontaneous reductive elimination. Overall, these observations appear to suggest that BPy‐Au‐mediated, propargyl ester‐based protein labeling acts via an activated ester intermediate, which contributes to our understanding of this process and will aid the expansion/optimization of gold‐catalyst usage in future bioconjugation applications, especially in vivo.
New Vistas in Transmetalation with Discrete “AgCF3” Species: Implications in Pd‐Mediated Trifluoromethylation Reactions
Authors: Martínez de Salinas Sara , Mudarra Ángel L. , Benet‐Buchholz Jordi , Parella Teodor , Maseras Feliu , Pérez‐Temprano Mónica H. 
Published: May 2018

AbstractThis work describes the employment of discrete “AgCF3” complexes as efficient transmetalating agents to PdII to surmount overlooked challenges related to the transmetalation step in Pd‐catalyzed trifluoromethylation processes. We report the participation of a unique silver ate (Cs)[Ag(CF3)2] complex, under stoichiometric and catalytic conditions, in the unprecedented one‐pot formation of PhCF3 using PhI as starting material. Moreover, we show that the transmetalation step, which is often ignored in these transformations, can also determine the success or failure of the coupling process.
Synthesis, Biological Activity, and Mechanism of Action of 2‐Pyrazyl and Pyridylhydrazone Derivatives, New Classes of Antileishmanial Agents
Authors: Coimbra Elaine S. , Antinarelli Luciana M. R. , de A. Crispi Mariana , Nogueira Thais C. M. , Pinheiro Alessandra C. , de Souza Marcus V. N. 
Published: May 2018

AbstractIn this work, we report the antileishmanial activity of 23 compounds based on 2‐pyrazyl and 2‐pyridylhydrazone derivatives. The compounds were tested against the promastigotes of Leishmania amazonensis and L. braziliensis, murine macrophages, and intracellular L. amazonensis amastigotes. The most potent antileishmanial compound was selected for investigation into its mechanism of action. Among the evaluated compounds, five derivatives [(E)‐3‐((2‐(pyridin‐2‐yl)hydrazono)methyl)benzene‐1,2‐diol (2 b), (E)‐4‐((2‐(pyridin‐2‐yl)hydrazono)methyl)benzene‐1,3‐diol (2 c), (E)‐4‐nitro‐2‐((2‐(pyrazin‐2‐yl)hydrazono)methyl)phenol (2 s), (E)‐2‐(2‐(pyridin‐2‐ylmethylene)hydrazinyl)pyrazine (2 u), and (E)‐2‐(2‐((5‐nitrofuran‐2‐yl)methylene)hydrazinyl)pyrazine (2 v)] exhibited significant activity against L. amazonensis amastigote forms, with IC50 values below 20 μm. The majority of the compounds did not show any toxic effect on murine macrophages. Preliminary studies on the mode of action of members of this hydrazine‐derived series indicate that the accumulation of reactive oxygen species (ROS) and disruption of parasite mitochondrial function are important for the pharmacological effect on L. amazonensis promastigotes.
Electrically Controlled Biochemical Release from Micro/Nanostructures for in vitro and in vivo Applications: A Review
Authors: Guo Jianhe , Fan Donglei 
Published: May 2018

AbstractTo release biosubstances, including drug molecules, DNAs, and proteins, at prescribed cellular and tissue locations with controllable rates is the Holy Grail of drug delivery that could enable an array of unprecedented in vitro and in vivo applications. Extensive research efforts have been focused on exploring innovative mechanisms and approaches for controlling biochemical release with prescribed dose, timing, and dynamics. Particularly, the utilization of electric fields to stimulate the release of biomolecules from synthesized micro/nanostructures has received considerable interest. In this review, we focus on the recent progresses in controlling the release of biomolecules with electric fields by a variety of mechanisms, including electrochemical desorption and actuation, electrically triggered erosion, and electrically driven nanopumps and mechanical motions. The research on external electric stimuli trigged biorelease has progressed rapidly and could make remarkable impact in single‐cell biology, cell‐cell communication, and drug discovery.
Visible‐Light‐Driven Reduction of CO2 to CO and Its Subsequent Valorization in Carbonylation Chemistry and 13C Isotope Labeling
Authors: Gotico Philipp , Del Vecchio Antonio , Audisio Davide , Quaranta Annamaria , Halime Zakaria , Leibl Winfried , Aukauloo Ally 
Published: May 2018

AbstractA convenient and safe approach in valorizing carbon monoxide (CO) produced from the photocatalytic reduction of carbon dioxide (CO2) has been investigated. Visible light was used to drive an optimized photocatalytic reduction using a ruthenium trisbipyridine complex as a sensitizer and a rhenium bipyridyl carbonyl complex as a catalyst to perform an efficient reduction of CO2 to CO, which was then simultaneously utilized in a palladium‐catalyzed aminocarbonylation reaction at room temperature. This approach provides safe handling of the produced CO which also opens the way for a more efficient application of 13C‐isotope and 14C‐radioisotope‐labeled CO2 in pharmaceutically relevant drug labeling.
“They've conspired against us”: Understanding the role of social identification and conspiracy beliefs in justification of ingroup collective behavior
Authors: Chayinska Maria , Minescu Anca 
Published: May 2018

AbstractThe present research investigates conditions under which beliefs in conspiracy theories predict the desire to justify ingroup behavior in the context of intergroup conflict. We propose that within the context of Ukraine's intergroup conflict over the annexation of Crimea, supporters (but not opponents) of the “Euromaidan” social movement are likely to validate protesters’ collective actions as just to the extent that they believe that the authorities are engaged in annexation‐related conspiracies. We also examine the moderating role of perceived political corruption in these processes. Using a public opinion survey of 315 Ukrainians, we found support for our hypothesized moderated mediation model—identification with “Euromaidan” increased beliefs in the annexation‐related conspiracy theories, which in turn, increased justification of protesters’ actions in the setting of intergroup conflict. However, this mediation was only observed among those supporters of the Euromaidan who perceived political corruption to be at a low or average level.
Damage spectra of global crustal seismic sequences considering scaling issues of aftershock ground motions
Authors: Wen Weiping , Zhai Changhai , Ji Duofa 
Published: May 2018

SummaryRecent studies and earthquakes have shown that the mainshock‐aftershock (MSAS) sequences would induce significant cumulative damage, and it is urgent to incorporate the MSAS sequences into performance‐based seismic design and resilience assessment. For this purpose, one of the key problems is how to accurately and quickly estimate the cumulative damage induced by MSAS sequences. This manuscript investigates the damage spectra of global crustal MSAS sequences and proposes a prediction equation of damage spectra as a tool to quantify the cumulative damage caused by MSAS sequences. The recorded MSAS ground motions from global crustal seismic sequences are collected. The structures are modeled by 4 different kinds of single degree of freedom systems with/without degradation and pinching behavior. The scaling indicator and scaling factor SF of aftershock ground motions are studied from the point of view of efficiency and accuracy. The results indicate that scaling aftershock ground motions with spectra acceleration Sa present the best efficiency. Applying the condition of SF smaller than or equal to 5.0 (ie, SF ≤ 5.0) can clearly reduce the bias induced by over‐scaling and meanwhile has no change on the dispersion of results. Strong aftershocks (eg, relative Sa greater than 0.8) can increase the damage spectra by the minimum level of 20% for non‐degrading systems, and quantitative effects of aftershocks strongly depend on the period of vibration, strength reduction factor, hysteretic behavior, and intensity of the aftershock ground motions. The proposed prediction equation shows high accuracy on the estimation of the cumulative damage induced by MSAS sequences.
Study of fire behaviour of facade mock‐ups equipped with aluminium composite material‐based claddings, using intermediate‐scale test method
Authors: Guillaume Eric , Fateh Talal , Schillinger Renaud , Chiva Roman , Ukleja Sebastian 
Published: May 2018

SummaryThe fire behaviour of a building façade is dependent on the overall system's performance, rather than the performance of the individual components. A façade system includes the cladding and the insulant's characteristics, but also the cavities, cavity barriers, mounting and fixings, substrate, and any singularities, such as window frames. This publication presents façade fire propagation test according to the ISO 13785‐1 standard, with additional heat release rate and gases analysis using FTIR. Tests have been performed on 9 different compositions of aluminium composite panels (ACM) with several insulants. For tested compositions, the cladding is the most important parameter driving global fire behaviour of façade mock‐ups. ACM‐PE‐based cladding systems gave very different results from the other solutions tested. This was especially visible in heat release rates, where fire intensity was very high, whatever the insulant used in the system. The contribution of the insulant was only remarkable in these tests during the decay phase. The cavity barrier was largely ineffectual in the 3 tests with ACM‐PE cladding, as the integrity of the cavity was not ensured.
Physicochemical properties, antioxidant capacities, and metal contents of virgin coconut oil produced by wet and dry processes
Authors: Ghani Nurul Aqilah A. , Channip Amy‐Arniza , Chok Hwee Hwa Phoebe , Ja'afar Fairuzeta , Yasin Hartini M. , Usman Anwar 
Published: May 2018

AbstractDifferent from cooking oils which contain long‐chain fatty acids, virgin coconut oil (VCO) has high medium‐chain fatty acids, making it a potential functional food which can provide some health benefits. In this study, our objective is to investigate the physicochemical properties, antioxidant capacity, and metal contents of the VCO extracted through four different processing methods: chilling and centrifugation; fermentation; direct micro expelling‐oven dried; and direct micro expelling‐sun‐dried processes. We found that the physicochemical properties, including moisture content, refractive index, viscosity, iodine value, saponification value, peroxide value, free fatty acid, and fatty acid content, of all the VCO conform to the Asian and Pacific Coconut Community (APCC) standard. All of the VCO predominantly contains lauric acid which is in the range of 48.40%–52.84% of the fatty acid content. The total phenolic content and DPPH radical‐scavenging activity (IC50) of the VCO was obtained to be in the range of 1.16–12.54 mg gallic acid equivalents (GAE)/g and 7.49–104.52 mg/ml, respectively, and the metal contents in the VCO were within the acceptable range of the recommended APCC limit. These findings ensure good quality and safety assurance of the VCO produced from the coconut grown in Brunei Darussalam through the different processing methods.
Maternal education and childhood immunization in Turkey
Authors: Özer Mustafa , Fidrmuc Jan , Eryurt Mehmet Ali 
Published: May 2018

AbstractWe study the causal effect of maternal education on childhood immunization rates. We use the Compulsory Education Law of 1997, and the differentiation in its implementation across regions, as instruments for schooling of young mothers in Turkey. The Compulsory Education Law increased the compulsory years of schooling of those born after 1986 from 5 to 8 years. We find that education of mothers increases the probability of completing the full course of diphtheria, pertussis, and tetanus and Hepatitis B vaccinations for their children. The results are robust to variations in regression specification and including various individual and community variables.
Anthropomorphizing information to enhance trust in autonomous vehicles
Authors: Niu Dongfang , Terken Jacques , Eggen Berry 
Published: May 2018

AbstractTrust is an essential condition for accepting and relying on autonomous vehicles. One of the well‐studied factors contributing to trust in automation systems is anthropomorphism. It is expected that anthropomorphism may also enhance trust in the field of autonomous vehicles. A study is presented that investigated the effect of anthropomorphic embodiment for information about the vehicle's maneuvers on people's trust in autonomous vehicles. In a driving simulator experiment deploying a between‐subjects design, participants (N = 39) were exposed to varying amounts of information displaying upcoming actions of an autonomous vehicle (symbolic information or symbolic + anthropomorphic information). Each group rated trust and liking for the test condition against a reference condition where no information about the upcoming actions was provided through questionnaires. Symbolic + anthropomorphic information resulted in significantly more trust than symbolic information. Through one‐sample tests, it was found that ratings for symbolic + anthropomorphic information were significantly different from no information, while symbolic information by itself was not. Ratings for perceived anthropomorphism were positively correlated with trust and liking. It is concluded that anthropomorphizing information may foster the perception of autonomous vehicles as social agents and enhance trust in those vehicles.
The importance of and need for rapid hydrologic assessments in Latin America
Authors: Riveros‐Iregui Diego A. , Covino Timothy P. , González-Pinzón Ricardo 
Published: May 2018

AbstractLong‐term observations are critical in hydrology to understand the dynamics of biological and physicochemical processes involved in and affected by the flux of water. Long‐term observations have been employed to provide basic understanding of the water cycle (e.g., infiltration, evaporation, run‐off generation, and groundwater–surface water interactions), but they are lacking in hydrologically relevant regions such as the Andes Mountains, including alpine watersheds. Although the call for long‐term data acquisition in Latin America has been made, the establishment of long‐term data collection centres remains logistically challenging. This ever‐growing scientific gap hinders our understanding of differences and similarities in hydrological processes of tropical and temperate regions. Furthermore, technological advances such as in situ optical sensors for water quantity and quality remain cost‐prohibitive for both short and long deployment at most existing research sites in Latin America, restricting researchers pursuing research funding or developing meaningful, intersite comparisons and syntheses. Here, we emphasize the importance of and need for rapid assessments (i.e., field campaigns conducted over a few days) for improved hypothesis development and mechanistic understanding of hydrological dynamics in Latin America. We report on rapid assessments conducted in the high‐elevation mountains (>3,000 m) of Colombia. Our results highlight rapidly changing dynamics in nutrient retention potential and dissolved CO2 (pCO2), as well as highly variable spatial distribution of water quality parameters (N, C, P, Cl) in areas with varying land use. We present an initial examination of the effects of land‐use change on stream nutrient dynamics in one of the most biodiverse and threatened ecosystems on Earth. We conclude that rapid assessments not only are necessary but also represent a cost‐effective way to develop clear, testable hypotheses to advance a hydrologic research agenda in Latin America and work towards long‐term hydrological knowledge and information for use by other scientists.
Chitosan/biphasic calcium phosphate scaffolds functionalized with BMP‐2‐encapsulated nanoparticles and RGD for bone regeneration
Authors: Gan Donglin , Liu Min , Xu Tong , Wang Kefeng , Tan Hui , Lu Xiong 
Published: May 2018

AbstractAdvancements in bone tissue engineering require the improvement of tissue scaffolds, which should not only exhibit suitable mechanical properties and highly porous structures, but also effectively carry signaling molecules that can mediate bone formation and tissue regeneration. In the present study, we established chitosan/biphasic calcium phosphate (CS/BCP) scaffolds functionalized with Arg–Gly–Asp (RGD) and BMP‐2‐loaded nanoparticles. The resulting scaffolds were highly similar to natural bone extracellular matrix (ECM) in terms of composition and structural properties. First, we synthesized CS/BCP composite bionic scaffolds via the freeze‐drying method. Then, RGD peptides were covalently conjugated onto the scaffolds via the EDC/NHS method. The BMP‐2‐encapsulated BSA nanoparticles were prepared via a desolvation method and then coated with CS and oxidized alginate to achieve sustained release of BMP‐2. In vitro cell culture and in vivo implantation tests confirmed that RGD and BMP‐2 synergistically enhanced cell attachment and spreading by providing integrin binding surface and facilitating osteogenic differentiation. In summary, the bioceramic/biopolymer scaffolds functionalized with signaling biomolecules successfully provided a favorable microenvironment for bone formation and thus serve as potential candidates for use in bone tissue engineering. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2613–2624, 2018.
Decreased expression of hsa_circ_0137287 predicts aggressive clinicopathologic characteristics in papillary thyroid carcinoma
Authors: Lan Xiabin , Cao Jun , Xu Jiajie , Chen Chao , Zheng Chuanming , Wang Jiafeng , Zhu Xuhang , Zhu Xin , Ge Minghua 
Published: May 2018

BackgroundCircular RNA (circRNA) is a new type of noncoding RNA that can serve as ideal biomarkers. Evidence has showed that circRNAs play an important role in carcinogenesis and cancer development. However, little is known about the diagnostic value of circRNAs in papillary thyroid carcinoma (PTC) as well as their associations with clinicopathologic characteristics of patients with PTC.MethodsThe expression levels of hsa_circ_0137287 were detected in 120 PTC and 60 adjacent noncancerous thyroid tissues by quantitative real‐time polymerase chain reaction. The relationships between the expression of hsa_circ_0137287 in PTC and the clinicopathologic factors were analyzed. Finally, receiver operating characteristic (ROC) curves were generated to assess the diagnostic value of hsa_circ_0137287 as a biomarker for PTC.ResultsThe expression of hsa_circ_0137287 was significantly downregulated in PTC tissues compared with adjacent noncancerous tissues (P < .0001). Downregulation of hsa_circ_0137287 correlated with aggressive clinicopathologic characteristics of PTC such as extrathyroidal extension (P < .001), lymph node metastasis (P = .022), advanced T stage (P < .001) and larger tumor size (P < .001). The ROC curves revealed that hsa_circ_0137287 had a potential diagnostic value in predicting malignancy, extrathyroidal extension and lymph node metastasis. The area under curves were 0.8973 (95% CI = 0.8452‐0.9494, P < .0001), 0.6885 (95%CI = 0.5908‐0.7862, P = .0009), and 0.6691(95%CI = 0.5641‐0.7742, P = .0034), respectively.ConclusionsOur findings suggest that hsa_circ_0137287 may serve as a novel biomarker for PTC.