bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of parenteral nutrition on quality of life, the family and gastrointestinal symptoms in children with intestinal failure
Authors: Thomassen Rut Anne , Kvammen Janne Anita , Bentsen Beint S. , Solheim Anna , Størdal Ketil , Henriksen Christine , Brun Anne Charlotte 
Published: November 2024

AbstractObjectivesIntestinal failure (IF) and dependency on parenteral nutrition (PN) are risk factors for lower health‐related quality of life (HRQOL) in children. Weaning from PN is a major goal of paediatric IF treatment, however, its impact on HRQOL remains unclear. This study aimed to assess HRQOL, gastrointestinal (GI) symptoms and family impact in children with IF in relation to their need for PN.MethodData were collected in a cross‐sectional study from children with IF and a reference group of healthy children using electronic versions of Paediatric Quality of Life Inventory™ forms.ResultsThe study included 56 children with IF and 48 healthy children. Parents of children with IF reported significantly lower HRQOL than healthy children (−8.7, p = 0.001). PN dependency did not influence HRQOL scores, but families with children dependent on PN had a lower family impact score than children weaned from PN (49.9 vs. 73.6, p < 0.001). Parents of children in the PN group reported more GI problems than those in the weaned group (−8.1, p = 0.04), and diarrhoea, gas and bloating were common symptoms of IF. GI symptoms varied according to PN dependency and IF aetiology. Multivariate analysis found a significant association between HRQOL and total GI symptom score (parent scores: 0.34, p = 0.02, self‐score 0.48, p = 0.02).ConclusionChildren with IF had lower parent‐reported HRQOL than healthy children. PN dependency did not affect HRQOL, however, the need for PN had a significant negative impact on family well‐being. GI symptoms may negatively impact HRQOL in the IF population.
PROTAC and Molecular Glue Degraders of the Oncogenic RNA Binding Protein Lin28
Authors: Kashkush Aseel , Furth‐Lavi Judith , Hodon Jiri , Benhamou Raphael I. 
Published: November 2024

AbstractThe interaction between proteins and RNA is crucial for regulating gene expression, with dysregulation often linked to diseases such as cancer. The RNA‐binding protein (RBP) Lin28 inhibits the tumor suppressor microRNA (miRNA) let‐7, making it a significant oncogenic factor in tumor progression and metastasis. In this study, a small molecule is used that binds Lin28 and blocks its inhibition of let‐7. To enhance its efficay, the inhibitor is transformed into degraders via two degradation approaches: Proteolysis Targeting Chimera (PROTAC) and molecular glue. A series of PROTAC bifunctional molecules and molecular glues capable of degrading Lin28 in cells.is developed Both strategies significantly reduce overexpressed Lin28 and alleviate cancer cellular phenotypes. Notably, the molecular glue approach demonstrates exceptional potency, surpassing PROTAC in several aspects. This outcome underscores the superior efficiency of the molecular glue approach for targeted Lin28 degradation and highlights its potential for addressing associated diseases with small molecules. Innovative small molecule strategies such as molecular glue and PROTAC technology for targeted RBP degradation, hold promise for opening new avenues in RNA modulation and addressing related diseases.
Low‐Cost Lightweight Quartz Fiber‐Reinforced Hybrid Aerogel Nanocomposite for High‐Temperature Oxidation Thermal Protection
Authors: Wang Jinming , Hu Honglin , Yang Yunhua , Li Junning , Geng Qiong , Zhu Shipeng , Yan Jiao 
Published: November 2024

AbstractAerogels are used to achieve lightweight heat insulation in composites. To minimize cost and ensure safety, nanocomposites must be prepared without flammable or explosive solvents at room temperature and ambient‐pressure drying. However, fabricating resin aerogel nanocomposites is challenging due to the tendency of porous structures to collapse owing to the complex surface tension in the multiphase system of fibers, resin particles, and solvent. A novel quartz fiber‐reinforced hybrid aerogel nanocomposite is successfully prepared using the sol–gel method with self‐assembly template polymerization. Two key factors in preventing aerogel collapse include the use of a cationic surfactant as a stabilizer for the initial template and as a surface tension improver during drying. The nanocomposite, with a density of 0.52 g·cm−3 and thermal conductivity of 0.046 W·m−1·K−1, exhibited a back‐face temperature rise of ≈96.4 °C after a 1500 s arc‐wind tunnel ablation test. The maximum ablation retreat is ≈0.26 mm. This novel nanocomposite shows potential for high‐temperature protection systems in extreme oxidation environments.
A General Bipenalty Formulation for Explicit Contact‐Impact Analysis With a Parameter Selection Criterion
Authors: Kwon Yun‐Jae , Kim Jin‐Gyun , Cho Sang Soon , González José A. 
Published: November 2024

ABSTRACTA general bipenalty formulation with a parameter selection criterion is proposed for explicit contact‐impact finite element analysis. In order to model the contact phenomenon using penalties, it is necessary to introduce an artificial contact stiffness that can increase the maximum natural frequency of the system. When a large stiffness penalty parameter is used, the stability condition forces to reduce the time step size, increasing at the same time the computational demands. A solution to avoid the small time step size requirement and possible instabilities is to include a mass penalty in addition to the stiffness penalty term, using a technique known as the bipenalty method. However, this method presents some other challenges, mainly related to the parameter selection criterion and its final accuracy. In this work, two important improvements for the bipenalty method are presented. (i) An element‐type and dimension‐independent criterion for the selection of penalty mass and stiffness parameters. (ii) A modified predictor‐corrector scheme, specifically designed for the bipenalty method, that improves the accuracy of contact‐impact problems. Different 1D, 2D, and 3D contact‐impact examples are used to illustrate the stability, applicability to general contact cases, and reduction of the zigzag effect and spurious oscillations exhibited by the proposed methods.
Controlling the trans effect induced by nitric oxide and carbon monoxide: H93C myoglobin versus H‐NOX sensors and soluble guanylate cyclase
Authors: Yoo Byung‐Kuk , Lambry Jean‐Christophe , Negrerie Michel 
Published: November 2024

AbstractMyoglobin (Mb) has been engineered to replace the proximal histidine (His93) with a cysteine in order to investigate the trans effect induced by diatomic ligands using time‐resolved electronic absorption spectroscopy. This single mutation induces a change of heme coordination state and bonding character which change carbon monoxide (CO) and nitric oxide (NO) dynamics. In H93C Mb the increased Fe2+–S distance weakens this bond which is replaced with a distal Fe2+–His64 ligation. We measured dynamics very different from wild type Mb but similar with those measured in soluble guanylate cyclase (sGC). Whereas NO induces a direct negative trans effect, the strain on His64 ligation is sufficient to counteract the positive trans effect due to CO. After photodissociation, geminate recombination of NO to the transient 4‐coordinate heme of H93C occurred with a fast time constant (6.9 ps) identical to that in sGC. Remarkably, we also observed picosecond geminate rebinding of CO to H93C Mb, similarly with sGC in the simultaneous presence of CO and an allosteric stimulator. This CO rebinding dynamics to the 4c‐heme in H93C Mb was never measured in other Mb mutants and demonstrates the existence of 5‐coordinate heme with CO, explaining the synergistic activation of sGC in presence of CO and a stimulator.
Mesopore‐Augmented Electrochemical CO2 Reduction on Nitrogen‐Doped Carbon
Authors: Han Xu , Zhang Ting , Biset‐Peiró Martí , Roldan Alberto , Ceccato Marcel , Lock Nina , Pedersen Steen Uttrup , Morante Joan Ramon , Arbiol Jordi , Daasbjerg Kim 
Published: November 2024

AbstractThe electrochemical carbon dioxide reduction reaction (eCO2RR) using nitrogen‐doped carbon (N–C) materials offers a promising and cost‐effective approach to global carbon neutrality. Regulating the porosity of N–C materials can potentially increase the catalytic performance by suppressing the concurrence of the hydrogen evolution reaction (HER). However, the augmentation of porosity usually alters the active sites or the chemical composition of catalysts, resulting in intertwined influences of various structural factors and catalytic performance. In this study, incorporating secondary carbon sources into the metal‐organic framework (MOF) precursor through nanocasting aimed to selectively enhance the mesoporous structure, allowing for deciphering this effect from other changes in the catalyst composition. Consequently, the developed N–C catalyst exhibited a significant surface area with abundant mesopores, leading to a maximum Faradaic efficiency (FE) for carbon monoxide (CO) of 95% at −0.50 V versus the reversible hydrogen electrode (vs. RHE). Furthermore, the FE for CO is enhanced across a wide potential range, surpassing previously reported metal‐free N–C eCO2RR catalysts. The investigation reveals that constructing mesoporous structures can induce excellent CO2 catalysis by enhancing the accessibility of active sites while establishing an elevated local pH at these sites.
Enhancing mechanical and thermal properties of rigid poly(vinyl chloride) composites via stearic acid‐treated zinc oxide filler
Authors: Mallem Oum Keltoum , Zerguine Narimene , Benabid Fatma Zohra , Zouai Foued 
Published: November 2024

AbstractRigid poly(vinyl chloride) (PVC) exhibits limitations in mechanical performance and thermal stability. The aim of this study is to develop composite and nanocomposite materials with enhanced properties using zinc oxide (ZnO) as a filler to address the limitations of rigid PVC. The objective is to produce a cost‐effective material with improved thermal stability and mechanical properties. To enhance dispersion and compatibility with PVC, the ZnO filler was surface‐treated with stearic acid through a mechanical treatment process. The PVC/ZnO composites were prepared via melt mixing using a Brabender plastograph. The Fourier transform infrared spectroscopy and x‐ray diffraction results indicate that the surface treatment significantly altered the ZnO microstructure, leading to improved ispersion within the PVC matrix. Consequently, this modification resulted in enhanced properties of the rigid PVC, with a notable improvement observed at a ZnO filler content of 2 wt%. The thermogravimetric results indicated that treated ZnO increased the thermal stability of PVC composites. The mechanical test (Tensile Testing) reveals that highest modulus of elasticity (2.8 GPa), tensile strength (41 MPa), and elongation at break (38%) was obtained with modified ZnO incorporation.Highlights
Stearic acid improved ZnO filler dispersion and compatibility in rigid PVC.
Treated PVC/ZnO composites showed better thermal stability and mechanical properties.
FTIR, XRD, and TGA confirmed the surface treatment's impact on composites.
Postlude: A Look Ahead
Authors: Herbst Gernot , Madonski Rafal 
Published: November 2024

Abstract
Here we deal with the future, both nearest and that a bit further. First, supported by the body of knowledge we have put forward with this book, we make a case for using ADRC in the future. Then, we provide key takeaways on how to use ADRC moving forward and how this book can facilitate that. And even though we are heading toward the end of Part II, this is not the end of the book yet. We explain what substantial information is still coming and why it can be especially useful to returning readers. Here we also gather and list all the “cooking recipes” which are ready-to-use procedures to tune and implement all ADRC variants covered in the book. Finally, we take a look at ADRC in a broader sense and discuss possible avenues for its further development.
Aligned yet large dipoles: a SMEFT study
Authors: Bonnefoy Quentin , Kley Jonathan , Liu Di , Rossia Alejo N. , Yao Chang-Yuan 
Published: November 2024

Abstract
We study a non-universal flavor scenario at the level of the Standard Model Effective Field Theory, according to which the matrix of Wilson coefficients cuW of an up-type electroweak quark dipole operator is aligned with the up-type Yukawa coupling. Such an alignment usually follows from the assumption of Minimal Flavor Violation (MFV), away from which we step by allowing the entries of cuW to be sizable along the first quark generations. A particular example, which we refer to as “inverse hierarchy MFV”, features Wilson coefficients inversely proportional to quark masses, and arises from BSM models respecting MFV and containing heavy fields that replicate the mass hierarchy of SM quarks. We then analyze the phenomenology driven by cuW at colliders and at lower-energy flavor experiments. We show that precision measurements of the process pp → Wh → γγℓν at FCC-hh could set an upper bound on |cuW| ≲ $$ \mathcal{O} $$
O
(10−2)(Λ/TeV)2, with Λ the cutoff of the effective field theory. This bound is an order of magnitude stronger than the existing LHC bounds. Moreover, we estimate that Wh → $$ b\overline{b}\ell \nu $$
b

b
¯

ℓ
ν
at HL-LHC could also give competitive bounds. In the low-energy regime, we consider bounds arising from rare kaon decays, which turn out to be loose, |$$ {c}_{uW}^{11} $$

c
uW
11

| <$$ \mathcal{O} $$
O
(1)(Λ/TeV)2. We finally demonstrate that our flavor and operator assumptions can be derived from a weakly-coupled UV model, which we choose to simultaneously illustrate the UV origin of inverse hierarchy MFV.
U(1)-charged Dark Matter in three-Higgs-doublet models
Authors: Kunčinas A. , Osland P. , Rebelo M. N. 
Published: November 2024

Abstract
We explore three-Higgs-doublet models that may accommodate scalar Dark Matter where the stability is based on an unbroken U(1)-based symmetry, rather than the familiar ℤ2 symmetry. Our aim is to classify all possible ways of embedding a U(1) symmetry in a three-Higgs-doublet model. The different possibilities are presented and compared. All these models contain mass-degenerate pairs of Dark Matter candidates due to a U(1) symmetry unbroken (conserved) by the vacuum. Most of these models preserve CP. In the CP-conserving case the pairs can be seen as one being even and the other being odd under CP or as having opposite charges under U(1). Not all symmetries presented here were identified before in the literature, which points to the fact that there are still many open questions in three-Higgs-doublet models. We also perform a numerical exploration of the U(1) × U(1)-symmetric 3HDM, this is the most general phase-invariant (real) three-Higgs-doublet model. The model contains a multi-component Dark Matter sector, with two independent mass scales. After imposing relevant experimental constraints we find that there are possible solutions throughout a broad Dark Matter mass range, 45–2000 GeV, the latter being a scan cutoff.
Discovering heavy neutrino-antineutrino oscillations at the Z-pole
Authors: Antusch Stefan , Hajer Jan , Oliveira Bruno M. S. 
Published: November 2024

Abstract
Collider-testable type I seesaw extensions of the Standard Model are generally protected by an approximate lepton number (LN) symmetry. Consequently, they predict pseudo-Dirac heavy neutral leptons (HNLs) composed of two nearly degenerate Majorana fields. The interference between the two mass eigenstates can induce heavy neutrino-antineutrino oscillations ($$ N\overline{N}\textrm{Os} $$
N

N
¯

Os
) leading to observable lepton number violation (LNV), even though the LN symmetry is approximately conserved. These $$ N\overline{N}\textrm{Os} $$
N

N
¯

Os
could be resolved in long-lived HNL searches at collider experiments, such as the proposed Future Circular e+e− Collider (FCC-ee) or Circular Electron Positron Collider (CEPC). However, during their Z-pole runs, the LN carried away by the light (anti)neutrinos produced alongside the HNLs prevents LNV from being observed directly. Nevertheless, $$ N\overline{N}\textrm{Os} $$
N

N
¯

Os
materialise as oscillating signatures in final state distributions. We discuss and compare a selection of such oscillating observables, and perform a Monte Carlo simulation to assess the parameter space in which $$ N\overline{N}\textrm{Os} $$
N

N
¯

Os
could be resolved.
Large pseudoscalar Yukawa couplings in the complex 3HDM
Authors: Boto Rafael , Lourenco Luis , Romão Jorge C. , Silva Joao P. 
Published: November 2024

Abstract
As LHC’s Run3 unfolds, we peer deeper into the couplings of the 125GeV Higgs (h125) and also test for extra scalars. Even before such extra scalars are found, one can probe them by using the fact that theories with multiple Higgs doublets allow for substantial deviations of the couplings of h125 from their SM values. Indeed, the observed couplings already place stringent limits on such theories. We investigate the curious possibility that h125 couples to the top quark mostly as a scalar, while it couples to the bottom quark mostly as a pseudoscalar. This possibility was allowed by 2017 data for the so-called C2HDM; a two Higgs doublet model with a single source of explicit CP violation. It was shown recently that this possibility disappears when using the full experimental data of 2024. Here we discuss a three Higgs doublet with explicit CP violation (C3HDM), and show that the curious CP-even/CP-odd t/b possibility is partly resuscitated, prompting further experimental exploration of this prospect.
Category of SET orders
Authors: Lan Tian , Yue Gen , Wang Longye 
Published: November 2024

Abstract
We propose the representation principle to study physical systems with a given symmetry. In the context of symmetry enriched topological orders, we give the appropriate representation category, the category of SET orders, which include SPT orders and symmetry breaking orders as special cases. For fusion n-category symmetries, we show that the category of SET orders encodes almost all information about the interplay between symmetry and topological orders, in a natural and canonical way. These information include defects and boundaries of SET orders, symmetry charges, explicit and spontaneous symmetry breaking, stacking of SET orders, gauging of generalized symmetry, as well as quantum currents (SymTFT or symmetry TO). We also provide a detailed categorical algorithm to compute the generalized gauging. In particular, we proved that gauging is always reversible, as a special type of Morita-equivalence. The explicit data for ungauging, the inverse to gauging, is given.
Non-analytic terms of string amplitudes from partial waves
Authors: Huang Yu-tin , Paul Hynek , Santagata Michele 
Published: November 2024

Abstract
We describe a general formalism based on the partial-wave decomposition to compute the iterative s-channel discontinuity of four-point amplitudes at any loop order. As an application, we focus on the low-energy expansions of type I and II superstring amplitudes. Besides providing new results for their leading and sub-leading logarithmic contributions beyond genus one, our approach elucidates the general structure of non-analytic threshold terms. In the case of open strings, the use of orthogonal colour projectors allows us to efficiently compute all contributions from different worldsheet topologies at a given loop order.
Tensor reduction for Feynman integrals with Lorentz and spinor indices
Authors: Goode Jae , Herzog Franz , Kennedy Anthony , Teale Sam , Vermaseren Jos 
Published: November 2024

Abstract
We present an efficient graphical approach to construct projectors for the tensor reduction of multi-loop Feynman integrals with both Lorentz and spinor indices in D dimensions. An ansatz for the projectors is constructed making use of its symmetry properties via an orbit partition formula. The graphical approach allows to identify and enumerate the orbits in each case. For the case without spinor indices we find a 1 to 1 correspondence between orbits and integer partitions describing the cycle structure of certain bi-chord graphs. This leads to compact combinatorial formulae for the projector ansatz. With spinor indices the graph-structure becomes more involved, but the method is equally applicable. Our spinor reduction formulae are based on the antisymmetric basis of γ matrices, and make use of their orthogonality property. We also provide a new compact formula to pass into the antisymmetric basis. We compute projectors for vacuum tensor Feynman integrals with up to 32 Lorentz indices and up to 4 spinor indices. We discuss how to employ the projectors in problems with external momenta.
Classics in abdominal radiology: the jumping deer sign
Authors: Elliott Samantha , Taros Trent , Lustig Adam 
Published: November 2024

AbstractThe “jumping deer sign” is an ultrasonographic pattern that aids in identifying normal liver anatomy and distinguishing it from pathology. It includes the portal vein (deer’s head and body), the gallbladder or cystic duct (tail), and the inferior vena cava (obstacle). This sign helps differentiate portal veins from intrahepatic ducts, crucial for diagnosing conditions like portal hypertension. It also assists in identifying gallbladder pathologies and assessing the IVC for hydration status. The jumping deer sign provides a clear reference for clinicians, improving diagnostic accuracy, especially for those with limited ultrasound experience.
Biological augmentation of anterior cruciate ligament reconstruction with bone marrow aspirate concentrate: a systematic review and meta-analysis of randomised controlled trials
Authors: Park Jae Yong , Ng Hing Cheung James Andrew , Todorov Dominik , Park Shin Young , Lim Hayeon , Shin Eunjae , Yoon Angelina , Ha Joon 
Published: November 2024

Abstract
Purpose
Biological augmentation of anterior cruciate ligament (ACL) reconstruction with bone marrow aspirate concentrate (BMAC) is gaining attention for its theoretical potential to enhance postoperative healing and recovery. However, its clinical benefits remain uncertain, and its high cost raises questions about efficacy. Hence, we systematically reviewed randomised controlled trials (RCTs) to evaluate the effectiveness of BMAC in ACL reconstruction.

Methods
Our search included Cochrane, EMBASE, OVID, PubMed, and Scopus databases for RCTs evaluating the use of BMAC in ACL reconstruction. Primary outcomes focused on International Knee Documentation Committee (IKDC) scores and Lysholm scores. Secondary outcomes included MRI-related outcomes and postoperative complications. Statistical analysis was conducted using Review Manager 5.4 (Cochrane Collaboration), with heterogeneity assessed using Cochrane’s Q test and I2 statistics.

Results
221 patients from five RCTs were included, with 109 (49.3%) receiving BMAC augmentation. Follow-up ranged from 11.05 to 24 months. No significant differences were found in postoperative IKDC scores between the BMAC and control groups at, three, six and 12 months. The BMAC group had significantly higher IKDC scores at 24 months; however, this difference was unlikely to be clinically significant. No significant differences were observed in postoperative Lysholm scores at 12 or 24 months. MRI-related outcomes suggested potential graft recovery improvement with BMAC, and complication rates were comparable between groups.

Conclusion
In summary, biological augmentation with BMAC in ACL reconstruction does not significantly improve early patient-reported outcomes but offers potential benefits in graft recovery without increasing complication rates.