bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spillover Effects of Fraud Allegations and Investor Sentiment
Authors: Darrough Masako , Huang Rong , Zhao Sha 
Published: June 2019

ABSTRACTWe examine whether a stock price spillover effect spreads through the method of listing or country of origin and whether this spillover effect changes when investor sentiment shifts. Using a sample of fraud allegations against Chinese companies that became public through Chinese reverse mergers (CRMs), we investigate whether firms that experienced negative spillover effects on their stock prices are those from the same country and/or with the same method of listing as the firms accused of fraud. We first show that the negative spillover effect channeled through the firm's country of origin becomes stronger when investor sentiment about Chinese companies becomes pessimistic, as evinced by significant declines in the stock prices of non‐fraudulent Chinese companies, including both CRMs and Chinese IPOs. Second, we show that the negative spillover effects on CRMs are stronger than those on Chinese IPOs and non‐Chinese reverse mergers, suggesting that both country and listing method are applicable to CRMs. Our findings indicate that (i) investor sentiment plays an important role in the spillover process involving fraud allegations and (ii) while the two channels could coexist, negative spillover effects that spread through the country of origin play a more prominent role than those that spread through the method of listing.
Diagnosis and management of Non‐IgE gastrointestinal allergies in breastfed infants—An EAACI Position Paper
Authors: Meyer Rosan , Chebar Lozinsky Adriana , Fleischer David M. , Vieira Mario C. , Du Toit George , Vandenplas Yvan , Dupont Christophe , Knibb Rebecca , Uysal Piınar , Cavkaytar Ozlem , Nowak‐Wegrzyn Anna , Shah Neil , Venter Carina 
Published: June 2019

AbstractIt is well‐established that food proteins, such as egg, soya, cow's milk and wheat, are detectable in breastmilk for many hours or days after ingestion. Exposure to these proteins is important to the process of developing tolerance but can also sometimes elicit IgE‐mediated and non–IgE‐mediated allergic symptoms in breastfed infants. Non–IgE‐mediated allergy, outside of food protein‐induced allergic proctocolitis and eosinophilic oesophagitis, is not well understood, leading to variations in the diagnosis and management thereof. A primary objective of the European Academy for Allergy and Clinical Immunology is to support breastfeeding in all infants, including those with food allergies. A Task Force was established, to explore the clinical spectrum of non–IgE‐mediated allergies, and part of its objectives was to establish diagnosis and management of non–IgE‐mediated allergies in breastfed infants. Eight questions were formulated using the Patient, Intervention, Comparison, Outcome (PICO) system and Scottish Intercollegiate Guideline Network (SIGN) criteria for data inclusion, and consensus was achieved on practice points through the Delphi method. This publication aims to provide a comprehensive overview on this topic with practice points for healthcare professionals.
High burden of premature ventricular contractions in structurally normal hearts: To worry or not in pediatric patients?
Authors: Sharma Nandita , Cortez Daniel , Imundo Jason R. 
Published: June 2019

AbstractBackgroundThere is paucity of data regarding the significance of high percentage of premature ventricular contractions (PVCs) in healthy children and their impact on left ventricular (LV) function and the risk of ventricular arrhythmias. The purpose of this study was to assess the prevalence of LV systolic dysfunction in children with frequent PVCs and determine whether PVC characteristics were predictive of LV dysfunction.MethodsWe performed a single‐center retrospective review to examine the prevalence of PVC‐induced cardiomyopathy and natural history of PVC burden in children with frequent PVCs. Children aged 6 months–21 years with PVCs noted on 24‐hr Holter monitoring studies were enrolled. The four categories included those with a PVC burden of >10%, 10%–20%, and those with more than 20% PVC burden.ResultsA total of 134 children were included, 65 with more than 10% PVCs and 31 with more than 20% PVCs. Median age of the patients was 10.5 years (IQR 6.1–14.8 years), with 79 males (54.5%). Median PVC burden was 8.7% (IQR 4.2%–16.9%) with median follow‐up of 2.8 years (IQR 1.2–4.6 years). During 2.8 years (1.3–4.3 years) of follow‐up, the PVC burden decreased by 67% of baseline PVC burden in those who did not undergo any intervention. There were no deaths.ConclusionPVCs in children with structurally normal hearts are associated with a relatively benign course, with trend toward spontaneous resolution.
Writing Truth to Power: Jonas Khemiri’s Work in Stockholm and New York
Authors: Wulff Helena 
Published: June 2019

SummaryThis article explores the work of Swedish writer Jonas Hassen Khemiri, of partly Tunisian origin, in terms of cultural translation and comparison between Stockholm and New York. I discuss three texts by Khemiri in different writing genres: first, an open letter to Sweden’s Minister of Justice, which went viral in 2013 and was also published in the New York Times, about racial profiling in Stockholm; second, the play I Call My Brothers, written in response to a failed terrorist attack in Stockholm in 2010 and staged in New York; third, the award‐winning novel Everything I Don’t Remember (2016b) selected as a 2016 Times Literary Supplement Book of the Year by Joyce Carol Oates. Why would Khemiri’s open letter, play, and novel that address new issues of power, stereotypes, and physical appearance in Sweden matter in the United States, with its deep‐rooted diversity? The conclusion is that the international success of these pieces has nothing to do with Sweden or an interest in Swedish contemporary life but can be understood as local variations on the global themes of terrorist crimes and racial profiling.
Drawing the Adult Child: U.S. Graphic Memoir and the Anthropologies of Kinship and Personhood
Authors: Magee Siobhan 
Published: June 2019

SummaryThis article argues the usefulness of the culturally pervasive and impactful genre of graphic memoir for addressing gaps in the anthropologies of kinship and personhood. It identifies a key figure in some sections of U.S. society: the “adult child.” Adult childness emerges from the graphic memoirs discussed here as when a person finds themselves particularly conscious of having (or having had) parents. To the perennially debated question of what connects kin in a U.S. context the article proposes: the past. Key facets of U.S. personhood and kinship are founded on the tenet that what happens in the lives of one’s parents and one’s childhood go a long way to explaining who an adult is.
Management and monitoring of opioid use in pregnancy
Authors: Rausgaard Nete Lundager Klokker , Ibsen Inge Olga , Jørgensen Jan Stener , Lamont Ronald Francis , Ravn Pernille 
Published: June 2019

AbstractOpioid use during pregnancy has serious consequences for mother and baby. The true extent of the problem is unknown and there is a need for better screening. Existing guidelines with respect to the management of pregnant women with opioid use are based on limited evidence. To improve recommendations for optimal identification, management, and treatment, publications on opioids in pregnancy were reviewed. Published literature from 2007 to 2017 was searched in PubMed, Cochrane and Embase databases. The review employed 60 publications from 210 studies identified, that were of varying quality and included randomized controlled trials, systematic reviews, meta‐analyses, and Cochrane reviews. The prevalence of opioid use in pregnancy is underestimated. Screening by urine testing and self‐reporting is acceptable to identify fetal exposure. To minimize risk, opioid agonist pharmacotherapy should replace the continued use of opioids or detoxification. Current guidelines recommend methadone and buprenorphine equally. However, recent studies indicate that buprenorphine has advantages over methadone. Accordingly, we suggest buprenorphine as first‐line therapy. Future studies should elaborate on better objective screening methods to prevent the consequences of fetomaternal opioid exposure.
Partnerships for interdisciplinary collaborative global well‐being
Authors: Halbreich Uriel , Schulze Thomas , Botbol Michel , Javed Afzal , Kallivayalil Roy Abraham , Ghuloum Suhaila , Baron David , Moreira Almeida Alexander , Musalek Michael , Fung Wai Lun Alan , Sharma Avdesh , Tasman Allan , Christodoulou Nikos , Kasper Siegfried , Ivbijaro Gabriel 
Published: June 2019

AbstractHealth is a state of complete physical, mental, and social well‐being and not merely the absence of disease or infirmity. The multifaceted intertwined nature of optimal health, mental health, and well‐being requires operational, sustainable interdisciplinary partnerships in order to improve personal and global well‐being and happiness. The initial step must be the assessment of the nature and magnitude of local problems in the global context. The WHO annual reports may be an adequate departure point as they can demonstrate the global nature of stressful situations and their association with physical and mental stress‐related disorders. Therein, mental health professionals should spearhead change and progress. Attitudes need to be pro‐active and partnerships are essential.Pertinent data should be evaluated by local experts who will determine the needs and how best to face them and achieve solutions. Hopefully, common regional denominators will lead to the formation of Regional Interdisciplinary Collaborative Alliances (RICAs) who will share needed resources and focus particularly on vulnerable populations. The RICAs would be supported by experts and technological facilities located in developed economy centers. The long‐term goal is to turn the concept of pursuit of happiness into a well‐perceived reality.
Effects of different protein sources completely replacing fish meal in low‐protein diet on growth performance, intestinal digestive physiology, and nitrogen digestion and metabolism in nursery pigs
Authors: Li Rui , Hou Gaifeng , Song Zehe , Wu Cong , Zhao Jianfei , Sun Xingdong , Xiang Xuxiang , Fan Zhiyong , Hou De‐xing , He Xi 
Published: June 2019

AbstractThe study compared the effects of selected proteins replacing fish meal in low‐protein diets on piglets’ growth performance, intestinal digestive physiology, and nitrogen digestion and metabolism. Five reduced CP, amino acid (AA)‐supplemented diets containing 4% of either S50, HP300, concentrated degossypolized cottonseed protein (CDCP), P50, or fish meal were assigned to six pens with 11 pigs for a 28‐day study period. Compared with fish meal, dietary proteins did not affect growth performance, apparent total tract digestibility (ATTD) of nutrients, serum hormone levels and biochemical parameters, apparent ileal digestibility (AID) of CP and most AA, colonic short‐chain fatty acid (SCFA) contents, duodenal and ileal morphology, digestive enzyme activity, and pH in small intestine of piglets. However, HP300, CDCP, and P50 decreased (p < 0.05) fecal N excretion per weight gain. AID of Ile in S50 and HP300 and Glu in P50 were improved (p < 0.05), and AID of Gly in other proteins was reduced (p < 0.05). S50 and P50 lowered (p < 0.05) the contents of colonic isobutyric and isovaleric. S50 and HP300 reduced (p < 0.05) jejunal villus height. CDCP increased (p < 0.05) the pepsin activity in stomach. S50, HP300, and CDCP decreased (p < 0.05) pH in the proximal colon. Overall, the selected proteins could completely replace fish meal in low‐protein diet without impairing piglets’ growth via maintaining intestinal digestive physiology, and nitrogen digestion and metabolism.
Social enterprise and sustainable development in Bangladesh and Korea: Opportunities and challenges
Authors: Cho Sangmi , Sultana Razia , Kwon Soil 
Published: June 2019

AbstractThe aim of this paper was to understand the similarities and differences between social enterprise (SE) systems in Korea and Bangladesh in terms of the emergence, background, development, and current status of the SE's policies and support systems in these two countries. This study employs a conceptual qualitative analysis, and the data used in this study were obtained from multiple reliable literature reviews. The data were analyzed based on a text‐by‐text comparison of social enterprises in the two countries, and the results were revealed through written explanation. In Korea, the SE system emerged as social employment creation plan after the currency crisis in 1997. Later, in 2007, this movement turned into the “Social Enterprise Promotion Act.” Conversely, in Bangladesh, the SE system emerged as a result of NGOs’ activities to “alleviate poverty” and “facilitate job creation” after the War of Independence in 1971 in an informal socioeconomic conditions. There is no explicit legal form of SEs in Bangladesh. This study also suggests the nature and scope of SEs and the barriers to sustainability of SEs in both countries. The study also emphasized the foundations to develop relevant policies as well as clear regulations for the future sustainability of the SEs of these two countries.
i‐GONAD: A method for generating genome‐edited animals without ex vivo handling of embryos
Authors: Ohtsuka Masato , Sato Masahiro 
Published: June 2019

AbstractThe recent development of genome editing technologies has enabled the creation of genome‐edited animals, with alterations at the desired target locus. The clustered regularly interspaced short palindromic repeats (CRISPR) system is widely used for this purpose because it is simpler and more efficient than other genome editing technologies. The conventional methods for creation of genome‐edited animals involve ex vivo handling of embryos (zygotes) for microinjection or in vitro electroporation. However, this process is laborious and time‐consuming, and relatively large numbers of animals are used. Furthermore, these methods require specialized skills for handling embryos. In 2015, we reported a novel method for the creation of genome‐edited animals without ex vivo handling of embryos. The technology known as Genome‐editing via Oviductal Nucleic Acids Delivery (GONAD) involved intraoviductal instillation of genome editing components into a pregnant female and subsequent in vivo electroporation of an entire oviduct. The genome editing components present in the oviductal lumen are transferred to preimplantation embryos in situ for introducing insertion or deletion (indel) mutations at the desired loci. This technology was further improved by optimizing several parameters to develop improved GONAD (i‐GONAD) for the efficient generation of mutant or knock‐in animals. In this review, we discuss the historical background, potential applications, advantages, and future challenges of GONAD/i‐GONAD technology.
Shortened G1 phase of cell cycle and decreased histone H3K27 methylation are associated with AKT‐induced enhancement of primordial germ cell reprogramming
Authors: Takehara Asuka , Matsui Yasuhisa 
Published: June 2019

AbstractPrimordial germ cells (PGCs) are reprogrammed into pluripotent embryonic germ cells (EGCs) under specific culture conditions, but the detailed mechanisms of PGC reprogramming have not yet been fully clarified. Previous studies have demonstrated that AKT, an important intracellular signaling molecule, promotes reprogramming of PGCs into EGCs. Because AKT likely inhibits p53 functions to enhance PGC reprogramming, and p53 negatively regulates cell cycle progression, we analyzed cell cycle changes in PGCs following AKT activation and found that the ratio of PGCs in the G1/G0 phase was decreased while that of PGCs in the G2/M phase was increased after AKT activation. We also showed that the expression of the CDK inhibitor p27kip1, which prevents the G1‐S transition and is transcriptionally repressed by p53, was significantly downregulated by AKT activation. The results suggested that the characteristic cell cycle changes of PGCs by AKT activation are, at least in part, due to decreased expression of p27kip1. We also investigated changes in histone H3K27 tri‐methylation (H3K27me3) by AKT activation in PGCs, because we previously found that decreased H3K27me3 was involved in PGC reprogramming via upregulation of cyclin D1. We observed that AKT activation in PGCs resulted in H3K27 hypomethylation. In addition, DZNeP, an inhibitor of the H3K27 trimethyl transferase Ezh2, stimulated EGC formation. These results together suggested that AKT activation promotes G1‐S transition and downregulates H3K27me3 to enhance PGC reprogramming.
Glycaemic stability of a cyclist with Type 1 diabetes: 4011 km in 20 days on a ketogenic diet
Authors: Nolan J. , Rush A. , Kaye J. 
Published: June 2019

AbstractBackgroundMaintaining glycaemic control during exercise presents a significant challenge for people living with Type 1 diabetes. Significant glycaemic variability has been observed in athletes with Type 1 diabetes in competitive contexts. While very‐low‐carbohydrate ketogenic diets have been shown to minimize glycaemic excursions, no published data have examined if this translates to exercise.Case reportWe report the case of a 37‐year‐old man with Type 1 diabetes who successfully undertook a 4011 km cycle across Australia over 20 consecutive days whilst consuming a very‐low‐carbohydrate ketogenic diet. Continuous glucose monitoring data capture was 98.4% for the ride duration and showed remarkable glycaemic stability, with a standard deviation of 2.1 mmol/l (average interstitial glucose 6.1 mmol/l) and 80.4% of time spent within a range of 3.9–10 mmol/l. Interstitial glucose was <3 mmol/l for 2.1% of this time, with only a single episode of symptomatic hypoglycaemia prompting brief interruption of exercise for carbohydrate administration.ConclusionThis case demonstrates the viability of a very‐low‐carbohydrate ketogenic diet in an individual with Type 1 diabetes undertaking exercise. While the effect of a very‐low‐carbohydrate ketogenic diet is yet to be examined more broadly in athletes with Type 1 diabetes, the glycaemic stability observed suggests that fat adaptation may attenuate glycaemic swings and reduce reliance on carbohydrate consumption during exercise for maintaining euglycaemia.
Structural insights into Entamoeba histolytica arginase and structure‐based identification of novel non‐amino acid based inhibitors as potential antiamoebic molecules
Authors: Malik Anjali , Dalal Vikram , Ankri Serge , Tomar Shailly 
Published: June 2019

Arginase, the binuclear metalloenzyme, is a potential target for therapeutic intervention in protozoan infections. Entamoeba histolytica infection causes amebiasis which is the second most common cause of protozoan‐related human deaths after malaria. Here, we report the crystal structure of E. histolytica arginase (EhArg) in complex with two known inhibitors Nω‐hydroxy‐l‐arginine (l‐NOHA) and l‐norvaline, and its product l‐ornithine at 1.7, 2.0, and 2.4 Å, respectively. Structural and comparative analysis of EhArg–inhibitor complexes with human arginase revealed that despite only 33% sequence identity, the structural determinants of inhibitor recognition and binding are highly conserved in arginases with variation in oligomerization motifs. Knowledge regarding the spatial organization of residues making molecular contacts with inhibitory compounds enabled in the identification of four novel non‐amino acid inhibitors, namely irinotecan, argatroban, cortisone acetate, and sorafenib. In vitro testing of the in silico‐identified inhibitors using purified enzyme proved that irinotecan, argatroban, cortisone acetate, and sorafenib inhibit EhArg with IC50 value (mm) of 1.99, 2.40, 0.91, and 2.75, respectively, as compared to the known inhibitors l‐NOHA and l‐norvaline with IC50 value (mm) of 1.57 and 17.9, respectively. The identification of structure‐based non‐amino acid inhibitory molecules against arginase will be constructive in design and discovery of novel chemical modulators for treating amebiasis by directed therapeutics.
Nitrogen‐dependent bacterial community shifts in root, rhizome and rhizosphere of nutrient‐efficient Miscanthus x giganteus from long‐term field trials
Authors: Liu Yuan , Ludewig Uwe 
Published: June 2019

AbstractThe perennial energy crop Miscanthus × giganteus is recognized for its extraordinary nitrogen‐use efficiency. While the remobilization of nitrogen (N) to the rhizome after the growth phase contributes to this efficiency, the plant‐associated microbiome might also contribute, as N‐fixing bacterial species had been isolated from this grass. Here, we studied established Miscanthus × giganteus plots in southern Germany that either received 80 kg N ha−1 a−1 or that were not N‐fertilized for 14 years. The bacterial communities of the bulk soil, rhizosphere, roots and rhizomes were analysed. Major differences were encountered between plant‐associated fractions. Nitrogen had little effect on soil communities. The roots and rhizomes showed less microbial diversity than soil fractions. In these compartments, Actinobacteria and N‐fixing symbiosis‐associated Proteobacteria depended on N. Intriguingly, N2‐fixing‐related bacterial families were enriched in the rhizomes in long‐term zero N plots, while denitrifier‐related families were depleted. These findings point to the rhizome as a potentially interesting plant organ for N fixation and demonstrate long‐term differences in the organ‐specific bacterial communities associated with different N supply, which are mainly shaped by the plant.
Older adults are prioritized in terms of waiting time under the emergency triage system in Guangzhou, China
Authors: Pan Wen , Zhang Kouxing , Li Haitao , Wu Miaolue , Weng Jianping 
Published: June 2019

AimTo assess whether elderly patients are prioritized under the emergency triage system in Guangzhou, China.MethodsThis was a cross‐sectional survey of clinical data from adult visitors to the emergency department of the Third Affiliated Hospital of Sun Yat‐sen University between 1 August 2015 and 31 December 2017. The primary end‐point was receiving the first medical service within the target waiting time, which varied according to the triage level of the patient. Multivariate logistic regression was used to determine whether age was an independent predictor of a shorter waiting time.ResultsData from 262 282 emergency patients were analyzed. The mean age of patients was 35.97 years, and 7.5% were aged ≥65 years. In total, 88.3% of patients received medical service within the target waiting time, and 87.4% of elderly patients received medical service within the target waiting time. Multivariate logistic regression analysis showed that advanced age was independently associated with receiving medical service within the target waiting time (adjusted odds ratio 1.258, 95% confidence interval 1.198–1.321; P < 0.001). The triage level, type of emergency subdivision, availability of outpatient services and time of day were also associated with receiving medical service within the target waiting time.ConclusionUnder the emergency triage system of the hospital, older adults are more likely to receive medical service within the target waiting time than younger patients. Geriatr Gerontol Int 2019; 19: 786–791.