bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐Omics Inform Invasion Risks Under Global Climate Change
Authors: Chen Yiyong , Gao Yangchun , Zhang Zhixin , Zhan Aibin 
Published: November 2024

ABSTRACTGlobal climate change is exacerbating biological invasions; however, the roles of genomic and epigenomic variations and their interactions in future climate adaptation remain underexplored. Using the model invasive ascidian Botryllus schlosseri across the Northern Hemisphere, we investigated genomic and epigenomic responses to future climates and developed a framework to assess future invasion risks. We employed generalized dissimilarity modeling and gradient forest analyses to assess genomic and epigenomic offsets under climate change. Our results showed that populations with genomic maladaptation did not geographically overlap with those experiencing epigenomic maladaptation, suggesting that genomic and epigenomic variations play complementary roles in adaptation to future climate conditions. By integrating genomic and epigenomic offsets into the genome–epigenomic index, we predicted that populations with lower index values were less maladapted, indicating a higher risk of future invasions. Native populations exhibited lower offsets than invasive populations, suggesting greater adaptive potentials and higher invasion risks under future climate change scenarios. These results highlight the importance of incorporating multi‐omics data into predictive models to study future climate (mal)adaptation and assess invasion risks under global climate change.
Joyful encounters: Dance, touch, and embodied ethics in times of COVID‐19
Authors: Biglieri Sara 
Published: November 2024

AbstractThis article explores the practice of Contact Improvisation during the COVID‐19 pandemic, focusing on how dance serves as a means of repair. Drawing on Erin Manning's posthumanist philosophy, woven into both the theoretical and embodied practice of dance, it envisions touch as a social‐relational bond capable of opening pathways to affective intensities, particularly the experience of joy. Employing and experimenting with affective ethnography, I explore the ethico‐political aspects of touch, extending ongoing discussions of ethics as deeply embodied. Specifically, I show how this exploration could lead to theorizing an “embodied ethic of repair”, enabling future‐oriented response‐ability and reclaiming joy as an affective force for navigating forthcoming bio‐political, social, and environmental challenges in and for organizations.
Note on the Fittingness of Negative Naming in Sacred Theology: The Corpus Dionysiacum and Father Bernard Lonergan, SJ1
Authors: Sherwood David Francis 
Published: November 2024

AbstractWithin a broadly Thomistic frame, this paper shows how simple apophaticism in the theology of Pseudo‐Dionysius the Areopagite is the more fitting mode of knowing the triune God, beyond the use of all divine names. Specifically, we will proceed using the work of Father Bernard Lonergan, SJ on theological fittingness. After setting forth Father Lonergan's understanding of fittingness, the paper will proceed through Dionysius's cataphatic names, apophatic names, and apophatic silence. The cataphatic and apophatic names, while true, useful, and fittingly said of God, will be shown to be imperfectly applied to God. As such, their fittingness pales in comparison to the simple silence of the intellect orientated towards God, despite such pure apophaticism's dissimilarity to normal human intellectual operations.
Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19
Authors: Lee Inyeong , Lupfer Christopher R. 
Published: November 2024

ABSTRACTThe COVID‐19 pandemic caused by the SARS‐CoV‐2 virus was arguably one of the worst public health disasters of the last 100 years. As many infectious disease experts were focused on influenza, MERS, ZIKA, or Ebola as potential pandemic‐causing agents, SARS‐CoV‐2 appeared to come from nowhere and spread rapidly. As with any zoonotic agent, the initial pathogen was able to transmit to a new host (humans), but it was poorly adapted to the immune environment of the new host and resulted in a maladapted immune response. As the host‐pathogen interaction evolved, subsequent variants of SARS‐CoV‐2 became less pathogenic and acquired immunity in the host provided protection, at least partial protection, to new variants. As the host‐pathogen interaction has changed since the beginning of the pandemic, it is possible the clinical results discussed here may not be applicable today as they were at the start of the pandemic. With this caveat in mind, we present an overview of the immune response of severe COVID‐19 from a clinical research perspective and examine clinical trials utilizing immunomodulating agents to further elucidate the importance of hyperinflammation as a factor contributing to severe COVID‐19 disease.
Exploring the Strengths and Resilience of Siblings of People With Intellectual and Developmental Disabilities
Authors: Lee Chung Eun , Shikarpurya Sehrish 
Published: November 2024

ABSTRACTBackground and AimsSiblings play a crucial role in shaping and guiding the experiences of their brother or sister with a disability across the lifespan. However, little is known about the positive outcomes of their roles and experiences as siblings. Understanding the positive outcomes challenges stereotypes and the stigma associated with disabilities and allows for a more holistic view of sibling experiences.MethodsWe conducted a survey with 140 adult siblings of people with disabilities to explore their strengths, resilience and community belonging.ResultsWe found that siblings highly rated their perceived strengths across various domains. Furthermore, siblings maintained high levels of resilience and most belonged to various organisations for social support. We also noted several strengths‐based factors that predicted siblings' resilience.ConclusionOur findings offer significant insights into siblings' inherent and developed strengths and the role of community networks in promoting sibling resilience and expanding their support systems.
Assessing Associations of Nurse‐Managed Hypertension Care on Pharmacotherapy, Lifestyle Counseling, and Prevalence of Comorbid Cardiometabolic Diseases in All Patients With Hypertension That Are Treated in Primary Care in Stockholm, Sweden
Authors: Ivarsson Charlotte , Bergqvist Monica , Wändell Per , Lindblom Sebastian , Norrman Anders , Eriksson Julia , Hasselström Jan , Sandlund Christina , Carlsson Axel C. 
Published: November 2024

ABSTRACTThe aim was to study if nurse‐managed hypertension care was associated with differences in pharmacotherapy, lifestyle counseling, and prevalence of comorbid cardiometabolic diseases among patients receiving care at primary health care centers. To assess the extent of nurses' involvement in the hypertension care, a questionnaire was distributed to all primary health care centers in Region Stockholm. Age‐adjusted logistic regression models were used to analyze the results, odds ratios with 99% confidence intervals. Data was acquired from VAL, the administrative databases of Region Stockholm in Sweden, encompassing all individuals 30 years or older with a registered hypertension diagnosis who attended to the primary health care center they were registered at. Our analysis comprised 119 267 patients diagnosed with hypertension registered in one of the 224 included primary health care centers. Of the 81 primary health care centers that responded to the questionnaire, 54 reported having nurse‐managed hypertension care. Nurse‐managed hypertension care was not significantly associated with differences in pharmacotherapy or patients’ comorbidity, except for diabetes. Primary health care centers with nurse‐managed hypertension care had a 10% greater adherence to national guidelines for lifestyle counseling (33.5%) compared to those without nurse‐managed hypertension care (22.5%). Regardless of the organizational form of hypertension care management, more men received lifestyle counseling according to guidelines compared to women. In‐house routines for hypertension care, with designated nurses, and booking systems were associated with more lifestyle counseling, which has been associated with signs of better hypertension care.
The oncogenic functions of SPARCL1 in bladder cancer
Authors: Li Changjiu , Yuan Hui , Chen Jun , Shang Kun , He Huadong 
Published: November 2024

AbstractSecreted protein, acidic and rich in cysteine‐like 1 (SPARCL1) belongs to the SPARC family of matricellular proteins. However, underlying functions of SPARCL1 in bladder cancer (BCa) remain understudied. We performed an integrated search for the expression patterns of SPARCL1 in relation to various clinicopathological features of BCa. We then carried out Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and gene set enrichment analysis (GSEA). Furthermore, we investigated the correlations between SPARCL1 and immunological features, such as tumour mutation burden (TMB), immune activation processes, immune checkpoint expression, tumour immune dysfunction and exclusion (TIDE) scores, and chemotherapeutic sensitivity in BCa. Our analysis revealed that SPARCL1 was downregulated across multiple cancers. In BCa, elevated SPARCL1 was linked with advanced histopathologic stage, higher T and N stage, and poorer prognosis in the clinical cohort. In vitro experiments demonstrated that increased SPARCL1 expression inhibited cell proliferation, migration, and invasion. Additionally, highly expressed SPARCL1 was linked to elevated immune, stromal and ESTIMATE scores, as well as an increase in naive B cells, M2 macrophages, and resting mast cells. We observed a moderate correlation between SPARCL1 expression and CD163, VSIG4 and MS4A4A, which are markers of M2 macrophages. Furthermore, SPARCL1 expression was positively related to TMB, immune activation processes, TIDE scores, immune checkpoint expression, and chemotherapeutic sensitivity in BCa. Our study highlights the potential involvement of SPARCL1 in macrophage recruitment and polarization and suggests its utility as a biomarker for prognosis in BCa.
Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain
Authors: Kuo Hung‐Chou , Lin Chia‐Ni , Tsai Sung‐Sheng , Chen Chiung‐Mei , Lyu Rong‐Kuo , Chu Chun‐Che , Ro Long‐Sun , Liao Ming‐Feng , Chang Hong‐Shiu , Weng Yi‐Ching , Hwang Jawl‐Shan 
Published: November 2024

ABSTRACTAimsThis study aimed to identify metabolic markers for diabetic peripheral neuropathic pain (DPNP) in patients with type 2 diabetes mellitus (T2DM).Materials and MethodsBlood metabolite levels in the amino acid, biogenic amine, sphingomyelin, phosphatidylcholine (PC), carnitines, and hexose classes were analyzed in nondiabetic control (n = 27), T2DM without DPNP (n = 58), and T2DM with DPNP (n = 29) using liquid chromatography tandem mass spectrometry. Variable importance projection (VIP) evaluation by partial least squares discriminant analysis was performed on clinical parameters and metabolites.ResultsSixteen variables with VIP > 1.0 (P < 0.05) were identified across all patient groups, and 5 variables were identified to discriminate between the two T2DM groups. DPNP patients showed elevated fasting blood glucose, glutamate, PC aa C36:1, lysoPC a C18:1, and lysoPC a C18:2, while low‐density lipoprotein cholesterol, phenylalanine, and tryptophan were reduced. Glutamate, lysoPC a C18:1, and lysoPC a C18:2 discriminated T2DM with DPNP from those without DPNP with an AUC of 0.671. The AUC was improved to 0.765 when ratios of metabolite pairs were considered.InterpretationBlood metabolites include glutamate, and phospholipid‐related metabolites implicated in neuropathic pain may have the potential as biomarkers for DPNP. Further investigation is required to understand the mechanism of action of these altered metabolites in DPNP.
Türkiye's responses to the 2023 earthquakes: An application of family adjustment and adaptation response model
Authors: Söylemez Yudum , Aydın Tuba 
Published: November 2024

AbstractAfter devastating earthquakes struck Türkiye in February 2023, the country faced the challenge of addressing the psychosocial needs of the survivors. This article uses the Family Adjustment and Adaptation Response (FAAR) model to conceptualize Türkiye's responses to the earthquakes in terms of its demands (i.e., cumulative strains and current stressors), capabilities (i.e., existing resources and coping mechanisms), and meaning/belief systems (i.e., shared meaning, religion/spirituality, and positive outlook/hope). A historical context is provided to better understand the cumulative tensions and resilience of the country, seeking ways to strengthen effective crisis responses in anticipation of an even bigger earthquake in the coming years. Additionally, this article may spark a conversation among family practitioners in different countries about how to collaborate on mobilizing resources during challenging times.
Feasibility, safety, and clinical outcomes of modified laparoscopic cervicoisthmic cerclage for refractory cervical insufficiency: A single‐arm clinical trial—Part 1
Authors: Seo Kohei , Ishikawa Tetsuya , Suzuki Yusuke , Izdebski Tatsuya , Goto Minako , Okuyama Ayumi , Oba Tomohiro , Otsuki Katsufumi , Sekizawa Akihiko , Ichizuka Kiyotake 
Published: November 2024

AbstractAimTo assess the feasibility, safety, and outcomes of modified laparoscopic transabdominal cerclage in patients with refractory cervical insufficiency.MethodsThis single‐arm clinical trial examined women with refractory cervical insufficiency who underwent modified laparoscopic transabdominal cerclage at a specialized center in Japan between December 2017 and May 2022. Various parameters related to patient demographics, surgical techniques, outcomes, and complications were evaluated.ResultsThe study enrolled 30 women with a median age of 36 years. The modified laparoscopic transabdominal cerclage was technically successful in all cases. The delivery rate and fetal survival rate at 28 days in the third trimester were both 93%. Surgical complication involving small bowel injury occurred in one case and was promptly repaired. No fetal complications or pregnancy losses occurred within 28 days of the procedure. Perinatal outcomes included a cesarean section rate of 93%, a neonatal intensive care unit admission rate of 30%, and an overall fetal survival rate of 93%. Additionally, no absence or reversal of end‐diastolic flow in the uterine artery was identified at the time of cerclage in any of the cases.ConclusionsThis study demonstrated the feasibility and safety of modified laparoscopic transabdominal cerclage for refractory cervical insufficiency. The procedure achieved a high delivery rate in the third trimester and a good overall fetal survival rate. The study findings highlight the importance of anatomical precision during thread placement in modified laparoscopic transabdominal cerclage. This technique is promising for treating refractory cervical insufficiency and potentially preventing second‐trimester losses and extreme preterm births.
Comparison Between Ecological Momentary Assessment and Self‐Report of Awake Bruxism Behaviours in a Group of Healthy Young Adults
Authors: Saracutu Ovidiu Ionut , Manfredini Daniele , Bracci Alessandro , Val Matteo , Ferrari Marco , Colonna Anna 
Published: November 2024

ABSTRACTObjectiveThe aim of this investigation was to compare the self‐reported frequency of awake bruxism (AB) behaviours by means of a validated single‐observation point questionnaire (i.e., Oral Behaviour Checklist [OBC]) with the frequency reported in real‐time with an Ecological Momentary Assessment (EMA) over 1 week.Materials and MethodsOne hundred healthy young adults took part in the study. The frequency of some activities belonging to the spectrum of AB behaviours (i.e., teeth contact, mandible bracing, teeth clenching, teeth grinding) was evaluated using the EMA approach with smartphone technology support over 1 week. The OBC questionnaire was used to evaluate the self‐reported frequency of the same AB behaviours. Spearman's rank correlation coefficient was adopted to test the correlation between the average score of each OBC question considered (i.e., teeth contact, mandible bracing, teeth clenching, teeth grinding) and the average frequency of the corresponding EMA item.ResultsStatistical analysis showed a weak‐to‐moderate level of correlation between the two different AB assessment methods. Mandible bracing showed the highest level of correlation, while teeth grinding had the lowest one.ConclusionsWhile the OBC represents a valid and easy‐to‐administer screening tool for evaluating bruxism behaviours, the EMA approach provides a more detailed real‐time report on AB behaviours.
Relationship Between Mandibular Position, Activation of the Masticatory Musculature and Free‐Throw Accuracy in Female Basketball Players
Authors: Delgado‐Delgado Raquel , Benito‐de‐Pedro Ana Isabel , Aguilera‐Rubio Ángela , Conde‐Vázquez Orlando , Jiménez‐Herranz Maura , Albarova‐Corral Isabel , Benito‐de‐Pedro María 
Published: November 2024

ABSTRACTBackgroundCurrent research relates jaw clenching to athletic performance, in terms of force and agility. However, the impact of jaw clenching on sports accuracy is unclear.ObjectivesTo analyse the impact of jaw position and chewing type on free‐throw accuracy and electromyographic (EMG) activity of masticatory muscles during free‐throws.MethodsCross‐sectional study with 25 female basketball players aged 18–44. Each participant executed 18 free‐throws under three different jaw conditions: mandibular rest, maximum intercuspation, and with interdental cotton rolls, in randomised order.ResultsChewing type and jaw position were not associated with shooting accuracy (p = 0.106; p = 0.778). There was a positive correlation between EMG activity of the right masseter and free‐throw accuracy at maximum intercuspation (rs = 0.402; p = 0.046). In contrast, negative correlations were found with other muscles when the occlusal vertical dimension was altered (rs = −0.619, p = 0.001; rs = −0.490; p = 0.013; rs = −0.534; p = 0.006). The chewing type affected the EMG of the left masseter in the altered occlusal vertical dimension (H = 6.969; p = 0.031). Significant differences in EMG recordings were observed across different mandibular positions during free‐throws (p < 0.001).ConclusionsWhile jaw positioning and chewing type do not impact free‐throw accuracy in amateur female basketball players, the EMG activity of masticatory muscles is linked to shooting performance. This highlights the need for further research on motor behaviour of masticatory muscles in precision sports, especially for athletes using intraoral devices.
Starch intake and changes in dental caries among adults: A longitudinal study in Finland
Authors: Jangda F. H. , Suominen A. L. , Lundqvist A. , Männistö S. , Golkari A. , Bernabé E. 
Published: November 2024

AbstractObjectiveTo evaluate the association between starch intake (amount and type) and changes in dental caries among adults over 11 years.MethodsData from 1679 adults, aged 30 years and over, who participated in three consecutive surveys in Finland were pooled for analysis. Participants completed a validated semi‐structured 128‐item food frequency questionnaire at baseline, from which total starch intake (g/day and % energy intake) and the intake (g/day) of seven food groups high in starch (potatoes, potato products, roots and tubers, refined grains, pasta, wholegrains, and legumes) were estimated. Dental caries was determined during clinical examinations and summarized using the DMFT score, which was treated as a repeated outcome. The association between baseline starch intake and 11‐year‐change in DMFT score was tested in linear mixed‐effects models adjusted for sociodemographic factors, behaviors, sugar intake, and health status.ResultsThe mean DMFT score was 21.9 (95%CI: 21.6, 22.2) in 2000 (baseline), increasing by 0.47 (95% CI: 0.38, 0.56) in 2004/05, and additionally by 0.33 (95%CI: 0.20, 0.45) in 2011. Total starch intake was not associated with change in DMFT. This finding was similar irrespective of how starch intake was expressed (g/day or %EI). Of the seven food groups evaluated, only the intake of pasta was inversely associated with the DMFT score at baseline, but not with the change in DMFT over time.ConclusionNeither the amount nor the type of starch intake was associated with changes in dental caries over 11 years among Finnish adults.
Patterns of local plant diversity and community saturation in deciduous forests in Europe
Authors: Paulssen Jolina , Brunet Jörg , Cousins Sara A. O. , Decocq Guillaume , De Frenne Pieter , De Smedt Pallieter , Hedwall Per‐Ola , Lenoir Jonathan , Liira Jaan , Lindgren Jessica , Naaf Tobias , Paal Taavi , Valdés Alicia , Verheyen Kris , Wulf Monika , Diekmann Martin 
Published: November 2024

AbstractQuestionsHow do local forest conditions and characteristics at the forest patch ‐ scale and landscape ‐ scale affect plot‐scale plant diversity in Europe? Do these patterns vary between forest specialists and generalists? Do community saturation patterns differ between forests varying in their surrounding landscape type?LocationDeciduous forests sampled along a European gradient from southwest to northeast comprising eight regions in five countries (France, Belgium, Germany, Sweden, Estonia).MethodsWe examined the effects of local conditions assessed by means of Ellenberg indicator values (soil moisture, soil nitrogen, soil pH, light availability), patch‐scale characteristics (patch‐scale plant diversity, forest patch age, forest patch size) and a landscape‐scale variable (representing low and high connectivity of forest patches) on plot‐scale plant diversity, separately for forest specialist and generalist species. Additionally, we ran regression models to examine community saturation patterns.ResultsWe found patterns of niche partitioning among forest specialists and generalists. Low light availability and medium soil moisture favored forest specialists, while generalists were mostly present at higher light availability and medium and high soil moisture. In general, we found the highest plot‐scale diversity at medium soil pH. Patch‐scale diversity showed a positive impact on plot‐scale diversity and plots in the high‐connectivity landscape had a higher diversity than plots in the low‐connectivity landscape. Further, we observed a high degree of community saturation in both landscape types.ConclusionThe positive impact of a high connectivity of forest patches on local plant diversity emphasizes the importance of small semi‐natural habitats like tree lines, unused field margins and hedgerows to enhance the potential dispersal of forest plants across agricultural landscapes. Community saturation patterns revealed the increasing relevance of local conditions and processes for plot‐scale diversity when patch‐scale diversity increases.