bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of different computational methods on 5-methylcytosine sites identification
Authors: Lv Hao , Zhang Zi-Mei , Li Shi-Hao , Tan Jiu-Xin , Chen Wei , Lin Hao 
Published: April 2019

Abstract5-Methylcytosine (m5C) plays an extremely important role in the basic biochemical process. With the great increase of identified m5C sites in a wide variety of organisms, their epigenetic roles become largely unknown. Hence, accurate identification of m5C site is a key step in understanding its biological functions. Over the past several years, more attentions have been paid on the identification of m5C sites in multiple species. In this work, we firstly summarized the current progresses in computational prediction of m5C sites and then constructed a more powerful and reliable model for identifying m5C sites. To train the model, we collected experimentally confirmed m5C data from Homo sapiens, Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana, and compared the performances of different feature extraction methods and classification algorithms for optimizing prediction model. Based on the optimal model, a novel predictor called iRNA-m5C was developed for the recognition of m5C sites. Finally, we critically evaluated the performance of iRNA-m5C and compared it with existing methods. The result showed that iRNA-m5C could produce the best prediction performance. We hope that this paper could provide a guide on the computational identification of m5C site and also anticipate that the proposed iRNA-m5C will become a powerful tool for large scale identification of m5C sites.
Long-Term Taste Impairment after Intensity-Modulated Radiotherapy to Treat Head-and-Neck Cancer: Correlations with Glossectomy and the Mean Radiation Dose to the Oral Cavity
Authors: Chen Wen-Cheng , Tsai Ming-Shao , Tsai Yao-Te , Lai Chia-Hsuan , Lee Chuan-Pin , Chen Miao-Fen 
Published: April 2019

AbstractWe explored the effects of various parameters on taste impairments (TIs) in head-and-neck (H&N) cancer patients receiving intensity-modulated radiotherapy (IMRT). From January 2014 to September 2017, 88 H&N cancer patients subjected to curative or postoperative IMRT were enrolled in this prospective study. All patients underwent at least 1 year of follow-up after IMRT. Quality-of-life assessments in terms of patient-reported gustatory function were measured using the taste-related questions of the European Organization for Research and Treatment of Cancer H&N35 questionnaires. At a median follow-up time of 27 months, 27 of 88 patients (30.7%) reported long-term TIs. In multivariate analyses, glossectomy most significantly predicted TIs (P = 0.04). The percentage of TIs (61.5%) was significantly (P = 0.03) higher in patients who underwent partial or total glossectomy than in patients who did not undergo surgery (28.0%) and those who underwent radical surgery without glossectomy (20.0%). When we excluded surgical patients from analyses, the mean radiation dose to the oral cavity was of borderline significance in terms of TI prediction (P = 0.05). Only 10.5% of patients suffered from TIs when the mean radiation dose was <5000 cGy compared with 38.7% when the mean dose was ≥5000 cGy. In conclusion, glossectomy is the major cause of long-term TIs in H&N cancer patients receiving IMRT. In patients who do not undergo glossectomy, reduction of the mean radiation dose to the oral cavity may reduce TIs after IMRT.
Frequency, predictors, and prognosis of ejection fraction improvement in heart failure: an echocardiogram-based registry study
Authors: Ghimire Anukul , Fine Nowell , Ezekowitz Justin A , Howlett Jonathan , Youngson Erik , McAlister Finlay A 
Published: April 2019

Abstract

Aims
To identify variables predicting ejection fraction (EF) recovery and characterize prognosis of heart failure (HF) patients with EF recovery (HFrecEF).

Methods and results
Retrospective study of adults referred for ≥2 echocardiograms separated by ≥6 months between 2008 and 2016 at the two largest echocardiography centres in Alberta who also had physician-assigned diagnosis of HF. Of 10 641 patients, 3124 had heart failure reduced ejection fraction (HFrEF) (EF ≤ 40%) at baseline: while mean EF declined from 30.2% on initial echocardiogram to 28.6% on the second echocardiogram in those patients with persistent HFrEF (defined by &lt;10% improvement in EF), it improved from 26.1% to 46.4% in the 1174 patients (37.6%) with HFrecEF (defined by EF absolute improvement ≥10%). On multivariate analysis, female sex [adjusted odds ratio (aOR) 1.66, 95% confidence interval (CI) 1.40–1.96], younger age (aOR per decade 1.16, 95% CI 1.09–1.23), atrial fibrillation (aOR 2.00, 95% CI 1.68–2.38), cancer (aOR 1.52, 95% CI 1.03–2.26), hypertension (aOR 1.38, 95% CI 1.18–1.62), lower baseline ejection fraction (aOR per 1% decrease 1.07 (1.06–1.08), and using hydralazine (aOR 1.69, 95% CI 1.19–2.40) were associated with EF improvements ≥10%. HFrecEF patients demonstrated lower rates per 1000 patient years of mortality (106 vs. 164, adjusted hazard ratio, aHR 0.70 [0.62–0.79]), all-cause hospitalizations (300 vs. 428, aHR 0.87 [0.79–0.95]), all-cause emergency room (ER) visits (569 vs. 799, aHR 0.88 [0.81–0.95]), and cardiac transplantation or left ventricular assist device implantation (2 vs. 10, aHR 0.21 [0.10–0.45]) compared to patients with persistent HFrEF. Females with HFrEF exhibited lower mortality risk (aHR 0.94 [0.88–0.99]) than males after adjusting for age, time between echocardiograms, clinical comorbidities, medications, and whether their EF improved or not during follow-up.

Conclusion
HFrecEF patients tended to be younger, female, and were more likely to have hypertension, atrial fibrillation, or cancer. HFrecEF patients have a substantially better prognosis compared to those with persistent HFrEF, even after multivariable adjustment, and female patients exhibit lower mortality risk than men within each subgroup (HFrecEF and persistent HFrEF) even after multivariable adjustment.
An Annual basal area growth model with multiplicative climate modifier fitted to longitudinal data for shortleaf pine
Authors: Saud Pradip , Lynch Thomas B , Cram Douglas S , Guldin James M 
Published: April 2019

Abstract
Understanding climatic influences on annual basal area growth (ABAG) rates of individual trees is necessary to predict future stand dynamics. We fitted nonlinear ABAG models for shortleaf pine (Pinus echinata Mill.) with climate variables linearly added to the arguments of logistic and exponential multiplicative functions of climate variables as climate modifiers to incorporate 14 growing seasons and 30 month-specific climate variables including standardized precipitation index. Data were collected from permanently established plots in Arkansas and Oklahoma. Six re-measurement events collected between 1985 and 2014 provided five growth periods (GPs) and ABAG models were fitted using a mixed-effects approach. Model performance was evaluated using likelihood ratio tests and fit statistics. Climate variables from GPs expressed as deviations from long-term means that performed better than other candidate variables included (1) month-specific: June mean maximum air temperature (°C) (DTMAX6), and September precipitation (mm) (DPPT9); and (2) growing seasons: mean maximum air temperature (°C) (DGTMAX) and precipitation (mm) (DGPPT). ABAG models fitted with multiplicative climate modifiers provided improved growth predictions compared with models fitted with climate variables linearly added to the argument of a logistic function. There was positive correlation with DGTMAX and negative correlation with DMPPT. In addition, 1°C increase in mean maximum temperature had a greater cumulative effect on ABAG rates of young versus old trees. Fitting ABAG models with climate modifiers are useful for assessing variations in productivity due to climate change in the future.
Everyone wants (a) peace: the dynamics of rhetoric and practice on ‘Women, Peace and Security’
Authors: True Jacqui , Wiener Antje 
Published: April 2019

Abstract
‘Women, Peace and Security’ (WPS) is not just any normative agenda: everyone wants a piece of it. WPS is characterized by unprecedented recognition by states at the United Nations Security Council (UNSC) and the presence of multiple stakeholders, including its own transnational NGO network focused on the first Resolution, 1325. The high degree of participation from civil society in framing the norm from the outset—driving their own access to contestation—makes WPS relatively unique among global normative agendas. It is therefore a good case in which to examine the ‘dynamics of dissent’ and test the effects of discursive and behavioural contestation on normative change. The article seeks to advance the thriving literature on the UN WPS agenda and to further develop the exploratory approach to contestation, which evaluates normative progress based on increased access of all those affected by the norm to practices of norm validation. It maps norm contestation at distinct sites, reflecting a sequence of WPS events referenced at the 2015 UNSC open debate on WPS. It evaluates practices of contestation with regard to affected WPS stakeholders' access to political agency and assesses ‘whose practices’ affect norm change and transformative change in the WPS agenda. The authors conclude that the relative access of the wide range of stakeholders to the different repertoires and constellations of contestation affects the outcomes of WPS. They suggest that scholars should evaluate diverse practices of contestation and identify expanding spaces and choices for a variety of local, national and regional perceptions of gender-equal peace and security. This article forms part of the special section of the May 2019 issue of International Affairs on ‘The dynamics of dissent’, guest-edited by Anette Stimmer and Lea Wisken.
Chemical Ecology of Marine Sponges: New Opportunities through “-Omics”
Authors: Paul Valerie J , Freeman Christopher J , Agarwal Vinayak 
Published: April 2019

AbstractThe chemical ecology and chemical defenses of sponges have been investigated for decades; consequently, sponges are among the best understood marine organisms in terms of their chemical ecology, from the level of molecules to ecosystems. Thousands of natural products have been isolated and characterized from sponges, and although relatively few of these compounds have been studied for their ecological functions, some are known to serve as chemical defenses against predators, microorganisms, fouling organisms, and other competitors. Sponges are hosts to an exceptional diversity of microorganisms, with almost 40 microbial phyla found in these associations to date. Microbial community composition and abundance are highly variable across host taxa, with a continuum from diverse assemblages of many microbial taxa to those that are dominated by a single microbial group. Microbial communities expand the nutritional repertoire of their hosts by providing access to inorganic and dissolved sources of nutrients. Not only does this continuum of microorganism–sponge associations lead to divergent nutritional characteristics in sponges, these associated microorganisms and symbionts have long been suspected, and are now known, to biosynthesize some of the natural products found in sponges. Modern “omics” tools provide ways to study these sponge–microbe associations that would have been difficult even a decade ago. Metabolomics facilitate comparisons of sponge compounds produced within and among taxa, and metagenomics and metatranscriptomics provide tools to understand the biology of host–microbe associations and the biosynthesis of ecologically relevant natural products. These combinations of ecological, microbiological, metabolomic and genomics tools, and techniques provide unprecedented opportunities to advance sponge biology and chemical ecology across many marine ecosystems.
Secession and post-sovereign constitution-making after 1989: Catalonia, Kosovo, and Quebec
Authors: Choudhry Sujit 
Published: April 2019

Abstract
The year 1989 marked the return of the right to self-determination to center stage in constitutional politics. It was at the root of demands for constitutional democracy; it was also invoked by minority nations to make claims for secession and independent states. That year also marked the emergence of a new model of “post-sovereign” constitution-making that rejects the idea of a sovereign people who can act unilaterally with unlimited power. While this new model was developed in the context of transitions to constitutional democracy, before and after 1989, minority nations have relied on the unilateral declaration of independence as a foundational act of constitution-making, which is firmly rooted in the pre-1989 sovereign mindset. Drawing on the example of the Supreme Court of Canada’s judgment in the Quebec Secession Reference, I sketch how we might complete the legacy of 1989 by extending the project of post-sovereign constitution-making to secession.
DynaCT-guided thoracic endovascular aortic repair in a patient with para-aortic malignant lymphoma
Authors: Masada Kenta , Kuratani Toru , Shimamura Kazuo , Sawa Yoshiki 
Published: April 2019

Abstract
Para-aortic malignant lymphoma invading the thoracic aorta can cause aortic rupture. Thoracic endovascular aortic repair (TEVAR) is a good option to treat aortic rupture associated with para-aortic malignancies. It is essential to detect the exact tumour location during TEVAR; however, it is often difficult to confirm the location with conventional 2-dimensional fluoroscopic or angiographic images. We describe successful TEVAR using syngo DynaCT (Siemens AG, Forchheim, Germany) in a 64-year-old man with para-aortic malignant lymphoma invading the descending aorta.
Homelessness and Inpatient Burn Outcomes in the United States
Authors: Kiwanuka Harriet , Maan Zeshaan N , Rochlin Danielle , Curtin Catherine , Karanas Yvonne , Sheckter Clifford C 
Published: April 2019

Abstract
Burn injuries are common in the homeless population. Little is known regarding whether homeless patients experience different outcomes when admitted for burns. We aim to 1) characterize the admitted homeless burn population, and 2) investigate differences in inpatient outcomes between the homeless and non-homeless populations. A retrospective cohort study was performed utilizing the Nationwide Inpatient Sample. Adult patients with complete data for burn characteristics were extracted. Variables included demographic, burn, and facility characteristics. Homelessness was identified with International Classification of Disease 9th edition codes. Outcomes were modeled with regression analysis and included length of stay, total operations, charges, disposition, and Patient Safety Indicators (PSIs). 43,872 encounters were included of which 0.76% were homeless. Homeless encounters were more likely to be male (P < .001) and Medicaid-insured (P < .001). Flame and frostbite injuries were more likely (P < .001), and the mean %TBSA was smaller (15.0 vs 16.8, P < .001). After adjustment, homeless patients had greater lengths of stay (11.5 vs 9.6, P = .046), greater charges ($73,597 vs $66,909, P = .030), fewer operations (P = .016), and three times higher likelihood leaving against medical advice (P = .002). There was no difference in PSIs or mortality. Homeless burn admissions represent a unique cohort that carries a higher comorbidity burden and experiences longer lengths of stay with greater difficulty in disposition. Ironically, these patients accumulate more charges with limited means to pay. Even though no differences were observed in PSIs or mortality, further research is needed to understand how the challenges within this population affect their recovery.
Behaviors Associated with Internet Use in Military Medical Students and Residents
Authors: Schmidt Gerald , Valdez Michelle , Farrell Maureen , Bishop Frank , Klam Warren P , Doan Andrew P 
Published: April 2019

Abstract

Introduction
Problematic use of video games, social media, and Internet-related activities may be associated with sleep deprivation and poor work performance. The Internet Addiction Test was given to military medical and nursing students and housestaff to assess problematic Internet use.

Methods
Medical and nursing students at the Uniformed Services University of the Health Sciences and residents from Naval Medical Center San Diego were contacted via email (n = 1,000) and given a survey that included the Internet Addiction Test (IAT) and questions asking about other specific lifestyle variables. Individuals who received an Internet Addiction Score (IAS) ≥50 were identified as likely experiencing harmful effects of Internet addiction (IA).

Results
Of 399 surveys submitted, 68 were omitted due to gross incompletion or failing to finish the entirety of the IAT. Of the participants included, 205 (61.1%) were male and 125 (37.9%) were female. The mean age was 28.6 years old (S.D. = 5.1 years). In regards to training status, completed surveys were assessed for 94 medical residents, 221 School of Medicine students, and 16 Graduate School of Nursing students. Our survey showed 5.5% of the participants (n = 18) indicated problems with Internet use that are concerning for IA.

Conclusions
The study results indicated that our population showed problematic Internet use in the lower range of global estimates of IA. Rates of IA further decreased between medical students and residents. Multiple lifestyle variables were significantly associated with IA score and may serve as indicators of a higher score. Interestingly, the use of social media during sleeping hours was most significantly associated with increased IAS. This paper discusses IA among military medical and nursing trainees and how problematic Internet use may affect work performance and force readiness.
Changes in Post-traumatic Stress Disorder Service Connection Among Veterans Under Age 55: An 18-Year Ecological Cohort Study
Authors: Murdoch Maureen , Kehle-Forbes Shannon , Spoont Michele , Sayer Nina A , Noorbaloochi Siamak , Arbisi Paul 
Published: April 2019

Abstract

Introduction
Mandatory, age-based re-evaluations for post-traumatic stress disorder (PTSD) service connection contribute substantially to the Veterans Benefits Administration’s work load, accounting for almost 43% of the 168,013 assessments for PTSD disability done in Fiscal Year 2017 alone. The impact of these re-evaluations on Veterans’ disability benefits has not been described.

Materials and Methods
The study is an 18-year, ecological, ambispective cohort of 620 men and 970 women receiving Department of Veterans Affairs PTSD disability benefits. Veterans were representatively sampled within gender; all were eligible for PTSD disability re-evaluations at least once because of age. Outcomes included the percentage whose PTSD service connection was discontinued, reduced, re-instated, or restored. We also examined total disability ratings among those with discontinued or reduced PTSD service connection. Subgroup analyses examined potential predictors of discontinued PTSD service connection, including service era, race/ethnicity, trauma exposure type, and chart diagnoses of PTSD or serious mental illness. Our institution’s Internal Review Board reviewed and approved the study.

Results
Over the 18 years, 32 (5.2%) men and 180 (18.6%) women had their PTSD service connection discontinued; among them, the reinstatement rate was 50% for men and 34.3% for women. Six men (1%) and 23 (2.4%) women had their PTSD disability ratings reduced; ratings were restored for 50.0% of men and 57.1% of women. Overall, Veterans who lost their PTSD service connection tended to maintain or increase their total disability rating. Predictors of discontinued PTSD service connection for men were service after the Vietnam Conflict and not having a Veterans Health Administration chart diagnosis of PTSD; for women, predictors were African American or black race, Hispanic ethnicity, no combat or military sexual assault history, no chart diagnosis of PTSD, and persistent serious mental illness. However, compared to other women who lost their PTSD service connection, African American and Hispanic women, women with no combat or military sexual assault history, and women with persistent serious illness had higher mean total disability ratings. For both men and women who lost their PTSD service connection, those without a PTSD chart diagnosis had lower mean total disability ratings than did their counterparts.

Conclusions
Particularly for men, discontinuing or reducing PTSD service connection in this cohort was rare and often reversed. Regardless of gender, most Veterans with discontinued PTSD service connection did not experience reductions in their overall, total disability rating. Cost-benefit analyses could help determine if mandated, age-based re-evaluations of PTSD service connection are cost-effective.
Association of Marijuana, Mental Health, and Tobacco in Colorado
Authors: Stewart Stephanie B. , Bhatia Devika , Burns Emily K. , Sakai Joseph T. , Martin Laura F. , Levinson Arnold H. , Vaughn Amber M. , Li Yaqiang , James Katherine A. 
Published: April 2019

Objectives:
Marijuana's evolving legality may change marijuana use patterns in adults. Co-use of marijuana and tobacco are strongly associated, and populations with mental health disorders are disproportionately likely to use either substance, but neither association has been assessed in the context of legal recreational marijuana. We assessed the associations of tobacco smoking with marijuana use and with mental health disorders in Colorado in 2015.

Methods:
Data came from a population-based survey of adults (n = 8023). Multiple logistic regressions were used with current tobacco smoking as the primary outcome. Past 30-day marijuana use and mental health status were the independent variables of interest. Covariates included age, sex, ethnicity, poverty level, and education.

Results:
Adults who used marijuana in the past 30 days had 3.4 (95% confidence interval [CI] 2.7, 4.2) greater odds of currently smoking tobacco compared to adults who had not recently used marijuana, after adjusting for sociodemographic and economic factors. A mental health disorder was independently associated with tobacco smoking (adjusted odds ratio [OR] 1.7, 95% CI 1.4, 2.1). Prevalence of co-use among adults self-reporting a mental health disorder was significantly higher compared those without a mental health disorder (11.1% vs 4.3%; P < 0.0001).

Conclusions:
This study examined the associations between mental health, marijuana use, and tobacco smoking after the legalization of recreational marijuana in Colorado. Adults using marijuana and/or self-reporting a mental health disorder were more likely to smoke tobacco and should be targeted for cessation interventions.