bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis: a meta-analysis
Authors: Feng Xiaodong , Liu Jingming 
Published: July 2019

Abstract
Background The purpose of this study was to investigate the association between IL-1A (-889C/T, rs1800587) polymorphism and susceptibility of chronic periodontitis. Methods A systematic literature search was carried out in the databases updated on July 1, 2019, including PubMed, Embase, Cochrane Library and Web of Science. Through STATA 14.0 software, the association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis was calculated by pooled odds rations (ORs) and 95% confidence intervals (CIs). Harbord test was used for the publication bias. Results The results of overall meta-analysis revealed that IL-1A (-889C/T) polymorphism was associated with the susceptibility of chronic periodontitis among all the genetic models, including allele contrast (T vs. C, OR (95% CI): 1.297 (1.038-1.622), P=0.022), dominant model (TT+CT vs. CC, OR (95% CI): 1.337 (1.015-1.761), P=0.039), recessive model (TT vs. CC+CT, OR (95% CI): 1.453 (1.138-1.856), P=0.003), and codominant model (TT vs. CC, OR (95% CI): 1.555 (1.187-2.038), P=0.001; CT vs. CC, OR (95% CI): 2.559 (1.245-5.260), P=0.011). The results of subgroup analyses indicated that IL-1A (-889C/T) polymorphism was closely related to the susceptibility of chronic periodontitis in African population (T vs. C, OR (95% CI): 1.277 (1.039-1.571), P=0.020; TT+CT vs. CC, OR (95% CI): 1.357 (1.061-1.735), P=0.015; TT vs. CC, OR (95% CI): 1.599 (1.115-2.292), P=0.011), in European population (TT vs. CC+CT, OR (95% CI): 1.645 (1.112-2.435), P=0.013; TT vs. CC, OR (95% CI): 1.639 (1.044-2.574), P=0.032) and in American population (CT vs. CC, OR (95% CI): 6.404 (3.000-13.669), P<0.001). Conclusions IL-1A (-889C/T) polymorphism is associated with the susceptibility of chronic periodontitis in African, European and American populations according to the currently available evidence. However, more large-scale, multi-ethnic case-control studies are required to be conducted in future to confirm the role of IL-1A (-889C/T) gene in the occurrence and development of chronic periodontitis.
Comparison between Ultrasound-guided TIVAD via the right innominate vein and the right internal jugular vein approach
Authors: Sun Xingwei , Bai Xuming , Shen Jiaofeng , Yu Ziyang , Zhuang Zhixiang , Jin Yong 
Published: July 2019

Abstract
Purpose: To compare the efficacy and safety of right internal jugular vein (IJV) approach and right innominate vein (INV) approach for US-guided totally implantable venous access devices (TIVADs), and to explore the advantages and disadvantages of the two approaches.
Methods: Six hundred and nineteen adult patients had long-term infusion and chemotherapy needs and inconvenience of peripheral venous infusion. Right INV approach was used to implant 339 cases of TIVADs, and right IJV approach was used to implant 280 cases of TIVADs. The success rate of one-time catheterization and the incidence of complications in the two groups were retrospectively analyzed.
Results: All patients were successfully implanted in TIVAD. The success rates of one-time puncture in INV group and IJV approach group were 98.53% (334/339) and 95.36% (267/280), respectively. There was significant difference between the two groups (P=0.020). The incidence of perioperative complications was 1.18% (4/339) and the long-term complications was 3.54% (12/339) in the right INV group. The incidence of perioperative complications was 1.43% (4/280) and the long-term complications was 3.93% (11/280) in the right INV group. There was no significant difference in the incidence of complications between the two groups (P=0.785，P=0.799, respectively).
Conclusions:
US-guided TIVADs via the right INV approach and the right IJV approach are both safe and reliable. The right INV approach improves the one-time puncture success rate, as long as the technique is properly operated, serious complications rarely occur.
Chinese Classical Prescription (Liang-Xue-Di-Huang Decoction) for Hemorrhoidal Disease: study protocol for a randomized controlled trial
Authors: Zhou Qing , Shi Shuo-yang , Wu Ben-sheng , Xu Cheng-biao , Geng Ji , Shen Zhao-feng , Chen Tuo , Zhang Dan , Jiang Feng , He Zhong-qi , chen Yu-gen 
Published: July 2019

Abstract
Background: Hemorrhoidal disease (HD) is one of the commonest proctologic condition in the general population. Medical therapy for HD has not been formally confirmed due to the inconsistent of results. Liang-Xue-Di-Huang Decoction, a kind of ancient Chinese classical prescription, has been used to treat HD from the 19th century in China. However, clinical research of Liang-Xue-Di-Huang Decoction in the treatment of HD is lack. We designed this study to evaluate the efficacy and safety of Liang-Xue-Di-Huang Decoction in the treatment of HD.
Methods/Design: A randomized, controlled, double blind, double-mimetic agent and multicenter trial to evaluate the efficacy and safety of Liang-Xue-Di-Huang Decoction is proposed. HD patients (stage I, Ⅱ, Ⅲ) will be randomly assigned into Liang-Xue-Di-Huang Decoction with the addition of Diosmine mimetic agent group and Diosmine with the addition of Liang-Xue-Di-Huang Decoction mimetic agent group. Patients will receive a 7-day treatments and a 7-day follow-up. The primary outcome measure is the French Bleeding Score in 7 and 14 days. The Secondary outcome measures are Goligher Prolapse Score and Quality-of-Life Score in 7 and 14 days.
Discussion: This study will provide objective evidence to evaluate the efficacy and safety of Liang-Xue-Di-Huang Decoction in treatment of HD.
Trial registration: Chinese Clinical Trial Registry. ChiCTR-1900022531.Registered 19 Apr 2019, http://www.chictr.org.cn/listbycreater.aspx.
Keywords: Hemorrhoidal disease, Liang-Xue-Di-Huang Decoction, Chinese classical prescription, Randomized controlled trial.
Precipitation effects on parasite, indicator bacteria, and wastewater micropollutant loads from a water resource recovery facility influent and effluent
Authors: Tolouei Samira , Autixier Laurène , Taghipour Milad , Burnet Jean-Baptiste , Bonsteel Jane , Duy Sung Vo , Sauvé Sébastien , Prévost Michèle , Dorner Sarah 
Published: July 2019

Abstract
The variability of fecal microorganisms and wastewater micropollutants (WWMPs) loads in relation to influent flow rates was evaluated for a water resource recovery facility (WRRF) in support of a vulnerability assessment of a drinking water source. Incomplete treatment and bypass discharges often occur following intense precipitation events that represent conditions that deviate from normal operation. Parasites, fecal indicator bacteria, and WWMPs concentrations and flow rate were measured at the WRRF influent and effluent during dry and wet weather periods. Influent concentrations were measured to characterize potential bypass concentrations that occur during wet weather. Maximum influent Giardia and C. perfringens loads and maximum effluent Escherichia coli and C. perfringens loads were observed during wet weather. Influent median loads of Cryptosporidium and Giardia were 6.8 log oocysts/day and 7.9 log cysts/day per 1,000 people. Effluent median loads were 3.9 log oocysts/day and 6.3 log cysts/day per 1,000 people. High loads of microbial contaminants can occur during WRRF bypasses following wet weather and increase with increasing flow rates; thus, short-term infrequent events such as bypasses should be considered in vulnerability assessments of drinking water sources in addition to the increased effluent loads during normal operation following wet weather.
Effect of Cu(II) on adsorption of tetracycline by natural zeolite: performance and mechanism
Authors: Guo Xuan , Wang Pengchao , Li Peng , Zhang Chengjun 
Published: July 2019

Abstract
The purpose of this study was to investigate the effect of Cu(II) on the adsorption performance and mechanism of tetracycline (TC) adsorption by natural zeolite (NZ) in aqueous solution. Low levels of Cu(II) (&lt;0.01 mmol/L) enhanced the extent of TC adsorption from ∼0.4 mg/g (in the absence of Cu(II)) to ∼0.5 mg/g (with 0.01 mmol/L Cu(II)), resulting in 99% removal of the total TC content. The TC adsorption gradually decreased with increase in the initial pH, but the coexistence of Cu(II) lowered the extent of decrease. The adsorption process was better simulated by the pseudo-second-order kinetics model, but the isotherm model that was more fitting changed from the Langmuir to the Freundlich model as Cu(II) increased, indicating the coexistence of Cu(II) and TC altered the adsorption mechanisms. However, the residual TC in solution increased from 0 to ∼6 mg/L as the concentration of Cu(II) increased from 0 to 1 mmol/L, suggesting a competition between TC and Cu(II) for the adsorption sites in NZ. Fourier transform infrared spectroscopy analysis showed that the functional groups on the surface of NZ changed after the adsorption of TC, suggesting that complex reactions had occurred on the surface of the adsorbent.
Confirmation the optimal aeration parameters for nitrogen removal and nitrous oxide emission in wastewater ecological soil infiltration systems with brown earth
Authors: Sun Yafei , Pang Junling , Wang Shiyao , Tao Tingting , Fu Xun , Zhang Ying , Sun Bo , Pan Jing 
Published: July 2019

Abstract
Nitrogen removal is an obstacle for the wide application of wastewater ecological soil infiltration (WESI) system in domestic wastewater treatment. In this study, matrix dissolved oxygen (DO), nitrogen removal and nitrous oxide (N2O) emission in aerated pilot WESI systems were investigated under different aeration times (1, 2, 3, 4 and 6 h/d) and aeration rates (1, 2, 3 and 4 L/min). The results showed that aerobic conditions in upper matrix and anoxic or anaerobic conditions in the subsequent matrix were developed in an aerated/non-aerated cycle at the optimal aeration condition of aeration time of 4 h/d and aeration rate of 3 L/min. Simultaneously, high removal efficiency of chemical oxygen demand (COD) (97.9%), NH4+-N (98.2%), total nitrogen (TN) (90.7%) and low N2O emission rate (13.2 mg/(m2 d)) were obtained. The results would provide optimal aeration parameters for application of intermittent aerated WESI systems.
Potential Drug Targets Against Hepatitis B Virus Based on Both Virus and Host Factors
Authors: Zhang Bing-Yi , Chai Dan-Ping , Wu Yi-Hang , Qiu Li-Peng , Zhang Yong-Yong , Ye Zi-Hong , Yu Xiao-Ping 
Published: July 2019

Background:Hepatitis B is a very harmful and epidemic disease caused by hepatitis B virus (HBV). Although an effective anti-HBV vaccine is available, chronic infection poses still a huge health burden in the whole world. The present anti-HBV drugs including nucleoside analogues and interferonalpha have their limitations without exception. There is no effective drug and therapeutic method that can really and truly cure hepatitis B so far. The variability of HBV genome results in that a significant number of patients develop drug resistance during the long-term use of anti-HBV drugs. Hence, it is urgently needed to discover novel targets and develop new drugs against hepatitis B.Objective:The review aims to provide the theory support for designing of the anti-HBV innovative drugs by offering a summary of the current situation of antiviral potential targets.Results and Conclusion:Since HBV is obligate intracellular parasite, and as such it depends on host cellular components and functions to replicate itself. The targeting both virus and host might be a novel therapeutic option for hepatitis B. Accordingly, we analyse the advances in the study of the potential drug targets for anti-HBV infection, focusing on targeting virus genome, on targeting host cellular functions and on targeting virus-host proteins interactions, respectively. Meanwhile, the immune targets against chronic hepatitis B are also emphasized. In short, the review provides a summary of antiviral therapeutic strategies to target virus factors, host factors and immune factors for future designing of the innovative drug against HBV infection.
Aligned Expression of IFI16 and STING Genes in RRMS Patients’ Blood
Authors: Helbi Sobhan , Ravanbakhsh Behnam , Karimi Mohammad , Kooti Wesam , Jivad Nahid 
Published: July 2019

Objective:
Multiple sclerosis (MS) is a chronic neurodegenerative disease of the central
nervous system. The most common disease phenotype is Relapsing-Remitting MS (RRMS). Beta interferons
are the first line of RRMS patients’ treatment. Interferon-inducible protein 16 (IFI16) as a DNA
sensing molecule and its downstream complex stimulator of interferon genes (STING) play a critical
role in the activation of type I interferons. Hence we aimed to evaluate the expression rate of IFI16 and
STING in RRMS patients’ blood under a different type of IFNβ treatment.

Methods:
In the present study, 99 individuals participated. The participants were divided into 4 groups:
28 control subjects, 25 new cases of RRMS patients, 25 RRMS patients treated with IFNβ-1a (B1a), 21
RRMS patients treated with IFNβ-1b (B1b). The EDTA-treated blood samples were taken and transferred
at standard conditions to the Cellular and Molecular Research Center of Shahrekord University
of Medical Sciences, RNA was extracted and converted into cDNA. To evaluate the expression of
IFI16 and STING, the Real-Time PCR method using SYBR Green/ROX qPCR master mix was performed
done. The level of genes expression was measured using 2–ΔΔCt method. The obtained data
were analyzed using SPSS v22 software.

Results:
Comparison of the IFI and STING mRNA expression in blood samples in association with
gender and age showed no significant differences (p>0.05). Also, the evaluation of IFI16 mRNA level
revealed that the IFI16 genes’ expressions were remarkably higher in the new case group compared to
the control group, however, STING expression did not show any significant difference. The mRNA
levels of IFI16 and STING in IFNβ-treated groups were significantly lower than the new case group
(p<0.001). Also, the genes’ expressions in both the IFNβ-treated groups were significantly lower compared
to the control group (p<0.001). In the assessment of the correlation of IFI16 and STING expressions
with age and sex in different research groups, no statistically significant differences were seen
(p>0.05).

Conclusion:
Perhaps the IFNβ therapy decreases the IFI16 and STING expression in a STINGdependent
pathway as a negative feedback mechanism for regulation of the immune system and suppression
of pro-inflammatory cytokines production. The important role of DNA sensing molecules and
STING-dependent pathway in MS gives a new insight into future treatment based on STING-direct
therapies.
Antinutrients in Plant-based Foods: A Review
Authors: Popova Aneta , Mihaylova Dasha 
Published: July 2019

Modern society has easy access to a vast informational database. The pursuit of sustainable green and healthy lifestyle leads to a series of food choices. Therefore, it is of importance to provide reliable, comprehensive and up-to-date information about food content including both nutritional and antinutritional elements.Nutrients are associated with positive effects on human health. Antinutrients, on the other hand, are far less popular for the contemporary man. They are highly bioactive, capable of deleterious effects as well as some beneficial health effects in man, and vastly available in plant-based foods. These compounds are of natural or synthetic origin, interfere with the absorption of nutrients, and can be responsible for some mischievous effects related to the nutrient absorption. Some of the common symptoms exhibited by a large amount of antinutrients in the body can be nausea, bloating, headaches, rashes, nutritional deficiencies,etc. Phytates, oxalates, and lectins are few of the well-known antinutrients.Science has acknowledged several ways in order to alter the negative influence antinutrients exhibiting on human health. Mechanical, thermal and biochemical approaches act synergistically to provide food with lower antinutritional levels.The purpose of this review was to synthesize the availability of antinutrients, clear their effect on the human body, and commemorate possible paths to disable them. This review provides links to the available literature as well as enables a systematic view of the recently published research on the topic of plant-based antinutrients.
Comparison Between Major Types of Arthritis Based on Diagnostic Ultrasonography
Authors: Roy Homagni Sikha , Cheng Chunxia , Zhu Qing , Yue Luo , Yang Shiyan 
Published: July 2019

Background:Ultrasound has been widely used in clinical settings for the assessment of different types of Arthritis as well as in their management. This Review study assessed the diagnostic value of Ultrasonography in comparison with major types of Arthritis namely Osteoarthritis (OA), Rheumatoid Arthritis (RA), Gouty Arthritis (GA), Pseudogout (Calcium Pyrophosphate Deposition Disease - CPPD), Psoriatic Arthritis (PA), Infectious Arthritis (IA) and Spondyloarthritis (SA).Methodology:Computerized literature search of PubMed was conducted from 1990 to present, for publications in English on diagnostic ultrasonography and major types of arthritis. A total of 206 publications were identified. Experimental and clinical studies that focused on the ultrasound features of the major types of Arthritis were accepted. A total of 52 out of the 206 publications, met our search criteria. Among these, 12 studies focused on OA, 7 on RA, 7 on GA, 5 on CPPD, 10 on PA, 4 on IA, and 7 on SA. From all the studies, some distinctive US features are reviewed for each of the major arthritis. Some of the features were unique and some overlapped.Conclusion:Ultrasound may demonstrate the ability to differentiate between the major types of Arthritis on a basic level when combined with history and physical examination. This can prove to be beneficial in the early diagnosis of the major types of arthritis, but with few limitations. This review literature shows that Ultrasound can be very helpful in bed side analysis of the major types of arthritis as well as in differentiating between them, because this modality besides being non-invasive is also very cheap.
Innovative Structural Solutions for Prefab Reinforced Concrete Hall-Type Buildings
Authors: Sorace Stefano , Terenzi Gloria 
Published: July 2019

Background:The anti-seismic design of prefab reinforced concrete buildings is usually carried out with a conventional ductility-based approach. This implies a remarkable plastic demand on columns, as well as damages to the connections of structural and non-structural members, for seismic events with comparable intensity to the basic design earthquake normative level.Objective:In view of this, a study was developed and aimed at extending to the field of new prefab reinforced concrete structures the application of advanced seismic protection strategies, capable of guaranteeing undamaged response up to the maximum considered earthquake normative level.Method:A benchmark building was designed as demonstrative case study for this purpose, in the three following hypotheses: (a) according to a traditional ductility-based approach; (b) by incorporating dissipative bracings, equipped with fluid viscous dampers; (c) by placing a seismic isolation system at the base, composed of a set of double curved surface sliders.Results:The results of the verification analyses show that the targeted performance for the design solutions b) and c) is obtained with sizes of columns and plinths notably smaller than those for the conventional design. This allows compensating the additional cost related to the incorporation of the protective devices, for the dissipative bracing system, and limiting additional costs below 25%, for the base isolation solution. At the same time, a supplemental benefit of the latter is represented by greater protection of contents and plants, as they are fully supported by the seismically isolated ground floor.Conclusion:The study highlights the advantages offered by the two advanced seismic protection technologies in an unusual field of application, guaranteeing an enhanced performance of structural and non-structural elements, as well as reduced member sizes, as compared to the traditional ductility-based design.
Evaluación de la aptitud clínica de los médicos pasantes en servicio social
Authors: Gómez López Víctor Manuel , Rosales Gracia Sandra 
Published: July 2019

Introducción: La evaluación de la aptitud clínica de los médicos pasantes en servicio social, es un indicador prioritario para la mejora en la formación de los recursos humanos para la atención de la salud. Objetivo: Evaluar el nivel de la aptitud clínica global y por indicadores, que muestran los médicos pasantes en servicio social, en la atención de los diez principales motivos de consulta en el primer nivel de atención. Método: Se realizó un estudio cuantitativo, descriptivo, observacional y transversal, en una escuela de medicina del sector privado. Se aplicó un cuestionario, con una validación desde el punto de vista de contenido, a una muestra poblacional de ochenta alumnos. Los padecimientos incluidos en la evaluación de la aptitud clínica fueron los diez principales motivos de consulta en el primer nivel de atención, de la cual solo se integraron seis componentes. Se utilizó estadística descriptiva e inferencial considerando un valor de p ≤ a 0.05 como estadísticamente significativo. Resultados: El promedio global de calificación de los alumnos en todos los casos presentados fue de 66.6 (± 9.5) con un valor mínimo de 53.5 y máximo de 98.0. Se observó un mejor resultado de la aptitud clínica, en la diabetes mellitus y sus complicaciones, así como en la preeclampsia-eclampsia. En el 60% de los participantes, el nivel de aptitud clínica global para la atención de los principales motivos de consulta en el primer nivel de atención, considerando el azar se ubicó en el nivel medio.No hubo diferencias según sexo. Conclusiones: La aptitud clínica global de los pasantes de medicina para la atención de los principales motivos de consulta es adecuada.
Las tecnologías del aprendizaje y del conocimiento (TAC) y la formación integral y humanista del médico
Authors: Parra Acosta Haydeé , José López Loya José , González Carrillo Eliazar , Moriel Corral Leticia , Vázquez Aguirre Alma Delia , González Zambada Nora Cecilia 
Published: July 2019

Introducción: Con los avances de las tecnologías y el internet de todas las cosas, se generan nuevas perspectivas en la formación de los médicos. De ahí la importancia de utilizar las tecnologías del aprendizaje y del conocimiento (TAC) que corresponden a las tecnologías de información (TIC) y comunicación orientadas a procesos pedagógicos para favorecer la formación humanista.
Objetivo: Mostrar la relación que existe entre la aplicación de las TAC, con la formación integral y humanista del médico por competencias.
Método: Estudio transversal no experimental, que se realizó mediante la aplicación de un instrumento, tipo cuestionario, a 152 estudiantes y 35 docentes de medicina, que mide la percepción que tienen de la formación humanista a través de las TAC. El cuestionario integró 63 ítems que se respondieron mediante una escala centesimal. Fue validado a través de un grupo piloto obteniendo un alpha de Cronbach de 0.92.
Resultados: Los resultados descriptivos mostraron que existe tendencia en considerar que la aplicación de las TAC en la formación médica contribuye más al desarrollo integral (87.60), al desempeño académico (83.8) y al desarrollo de competencias (80.80), que a la formación humanista (58.9). Sin embargo, se observó una relación significativa entre la educación médica a través de las TAC y la formación humanista del médico (r. 0.82). Lo cual indica que la percepción que tienen los docentes y estudiantes, no solo es distinta a los resultados correlacionales, sino que predisponen la formación de los médicos acorde a los retos del contexto socioeducativo actual.