bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tau seeding activity anticipates phospho-tau pathology in Alzheimer’s disease
Authors: Kaufman Sarah K. , Del Tredici Kelly , Thomas Talitha L. , Braak Heiko , Diamond Marc I. 
Published: February 2018

AbstractAlzheimer’s disease (AD) is characterized by accumulation of tau neurofibrillary tangles (NFTs) and, according to the prion model, transcellular propagation of pathological “seeds” may underlie its progression. Staging of NFT pathology with phospho-tau antibody is useful to classify AD and primary age-related tauopathy (PART) cases. The locus coeruleus (LC) shows the earliest phospho-tau signal, whereas other studies suggest that pathology begins in the transentorhinal/entorhinal cortices (TRE/EC). The relationship of tau seeding activity, phospho-tau pathology, and progression of neurodegeneration remains obscure. Consequently, we employed an established cellular biosensor assay to quantify tau seeding activity in fixed human tissue, in parallel with AT8 phospho-tau staining of immediately adjacent sections. We studied four brain regions from each of n=247 individuals across a range of disease stages. We detected the earliest and most robust seeding activity in the TRE/EC. The LC did not uniformly exhibit seeding activity until later NFT stages. We also detected seeding activity in the first temporal gyrus and visual cortex at stages before NFTs and/or AT8-immunopositivity were detectable. AD and putative PART cases exhibited similar patterns of seeding activity that anticipated histopathology across all NFT stages. Our findings are consistent with the prion model and suggest that pathological seeding activity begins in the TRE/EC rather than in the LC, and may offer an important addition to classical histopathology.
ALOXE3 is a hepatic fasting-responsive lipoxygenase that enhances insulin sensitivity via hepatic PPARγ
Authors: Higgins Cassandra B. , Zhang Yiming , Mayer Allyson L. , Fujiwara Hideji , Stothard Alicyn I. , Graham Mark J. , Swarts Benjamin M. , DeBosch Brian J. 
Published: February 2018

ABSTARCTThe hepatic glucose fasting response is gaining traction as a therapeutic pathway to enhance hepatic and whole-host metabolism. However, the mechanisms underlying these metabolic effects remain unclear. Here, we demonstrate the lipoxygenase, ALOXE3, is a novel effector of the thepatic fasting response. We show that ALOXE3 is activated during fasting, glucose withdrawal, and trehalose/trehalose analogue treatment. Hepatocyte-specific ALOXE3 expression reduced weight gain and hepatic steatosis in dietaryand genetically obese (db/db) models. ALOXE3 expression moreover enhanced basal thermogenesis and abrogated insulin resistance in db/db diabetic mice. Targeted metabolomics demonstrated accumulation of the PPARγ ligand, 12-KETE in hepatocytes overexpressing ALOXE3. Strikingly, PPARγ inhibition reversed hepatic ALOXE3-mediated insulin sensitization, suppression of hepatocellular ATP production and oxygen consumption, and gene induction of PPARγ coactivator-1a (PGC1α) expression. Moreover, hepatocyte-specific PPARγ deletion reversed the therapeutic effect of hepatic ALOXE3 expression on diet-induced insulin intolerance. ALOXE3 is therefore a novel effector of the hepatocellular fasting response that leverages both PPARγ-mediated and pleiotropic effects to augment hepatic and whole-host metabolism, and is thus a promising target to ameliorate metabolic disease.
Spatial contextual cueing is not a limiting factor for expert performance in the domain of team sports or action video game playing
Authors: Schmidt Anne , Geringswald Franziska , Pollmann Stefan 
Published: February 2018

AbstractWe investigated in two experiments if handball and action video game players show improved implicit learning of repeated spatial configurations for efficient search guidance in comparison to a control group without sport or video game proficiency. To this end, we used both a sport-specific pseudo 3-D contextual cueing task and the original contextual cueing paradigm (Chun & Jiang, 1998). Contextual cueing was present in all groups. However, handball and action video game players did not differ in the strength of contextual cueing from the control group. Action video game players had shorter search times than controls in both experiments. In contrast, the handball players searched faster than controls in the sport-specific displays of Experiment 1 but not in the symbolic search task of Experiment 2. Thus, our findings provide no evidence that contextual cueing is a limiting factor for expert performance in the domain of team sports or action video game playing.
Incomplete reprogramming of cell-specific epigenetic marks during asexual reproduction leads to heritable phenotypic variation in plants
Authors: Wibowo Anjar , Becker Claude , Durr Julius , Price Jonathan , Spaepen Stijn , Hilton Sally , Putra Hadi , Papareddy Ranjith , Saintain Quentin , Harvey Sarah , Bending Gary D. , Schulze-Lefert Paul , Weigel Detlef , Gutierrez-Marcos Jose 
Published: February 2018

AbstractPlants differ from animals in their capability to easily regenerate fertile adult individuals from terminally differentiated cells [1]. This unique developmental plasticity is commonly observed in nature where many species can reproduce asexually through the ectopic initiation of organogenic or embryogenic developmental programs [2, 3]. However, it is not currently known if this developmental reprogramming is coupled to a global epigenomic resetting, or what impact it has on the phenotype of the clonal progeny. Here we show that plants asexually propagated via induction of a zygotic developmental program do not fully reset cell-specific epigenetic imprints. These imprints are instead inherited even over multiple rounds of sexual reproduction, becoming fixed in hybrids and resulting in heritable molecular and physiological phenotypes that depend on the founder cell used. Our results demonstrate how novel phenotypic variation in plants can be unlocked through the incomplete reprogramming of cell-specific epigenetic marks during asexual propagation.
Tectal stem cells display diverse regenerative capacities
Authors: Lindsey Benjamin W. , Aitken Georgia E. , Tang Jean K. , Khabooshan Mitra , Vandestadt Celia , Kaslin Jan 
Published: February 2018

AbstractHow diverse adult stem and progenitor populations regenerate tissue following damage to the CNS remains unknown across most neurogenic domains. To understand the role of quiescent radial-glial (qRG) stem cells during regeneration, we tested the hypothesis that qRG could be induced to proliferate and produce newborn neurons. We designed a stab lesion assay in the midbrain tectum of the adult zebrafish to target an isolated population of qRG, and investigated their proliferative behaviour, differentiation potential, and requirement of Wnt/β-catenin signalling for the regenerative response. EdU-labelling showed that a small proportion of qRG transit to a proliferative state (pRG), but that progeny of pRG are restricted to a radial-glial fate. Lesion promoted upregulation of proliferation and neurogenesis from neuro-epithelial-like amplifying progenitors (NE-Ap) of the tectal marginal zone (TMZ). Homeostatic levels of Wnt/β-catenin signalling persisted under lesioned conditions in the qRG/pRG population, whereby increased β-catenin staining and axin2 expression was present in the NE-Ap progenitor zone. Attenuation of Wnt signalling using Dickkopf-1, demonstrated that proliferative responses post-injury appeared to be Wnt-independent. Our results align with the emerging view that adult stem/progenitor phenotypes are characterized by discrete, rather than mutual, regenerative programs and that different stem cell domains employ different modes of regeneration.
Stable between-subject statistical inference from unstable within-subject functional connectivity estimates
Authors: Vidaurre Diego , Woolrich Mark W. , Winkler Anderson M. , Karapanagiotidis Theodoros , Smallwood Jonathan , Nichols Thomas E. 
Published: February 2018

AbstractSpatial or temporal aspects of neural organisation are known to be important indices of how cognition is organised. However, measurements and estimations are often noisy and many of the algorithms used are probabilistic, which in combination have been argued to limit studies exploring the neural basis of specific aspects of cognition. Focusing on static and dynamic functional connectivity estimations, we propose to leverage this variability to improve statistical efficiency in relating these estimations to behaviour. To achieve this goal, we use a procedure based on permutation testing that provides a way of combining the results from many individual tests that refer to the same hypothesis. This is needed when testing a measure whose value is obtained from a noisy process, which can be repeated multiple times, referred to as replications. Focusing on functional connectivity, this noisy process can be: (i) computational, e.g. when using an approximate inference algorithm for which different runs can produce different results or (ii) observational, if we have the capacity to acquire data multiple times, and the different acquired data sets can be considered noisy examples of some underlying truth. In both cases, we are not interested in the individual replications but on the unobserved process generating each replication. In this note, we show how results can be combined instead of choosing just one of the estimated models. Using both simulations and real data, we show the benefits of this approach in practice.
Beyond exchange and prosocial motives, is altruistic helping a valid motive for organizational citizenship behavior?
Authors: Cheung Fung Yi Millissa , Peng Kelly , Wong Chi-Sum 
Published: February 2018

PurposeThe argument in this study is that employees differ in their motives in helping their organizations when they know that they may not be paid back for their efforts. This paper aims to examine whether these motives will lead to greater extra-role contribution in an organization.Design/methodology/approachThe data of 124 pairs of employee in China have been used to develop and test the measurement of an “altruistic helping of organization” (AHO) in a pilot sample. In addition, AHO had been then tested as a motive for organizational citizenship behavior (OCB) using data collected from 245 pairs of employees in China.FindingsData from 124 pairs of employees in China have been used to develop and test the measurement of “altruistic helping of organization” in a pilot sample. The authors have proposed and validated whether procedural justice and conscientiousness predict for a new OCB motive – AHO, which explains for an incremental predictive power over the existing motives of OCB, namely, instrumentality, social exchange with the organization, organizational concern, prosocial values and impression management, on a data collected from 245 pairs of employees in China.Research limitations/implicationsThis is a cross-sectional study. In addition, the authors have only taken in samples in China, which may not be generalizable to other context.Practical implicationsPractitioners can devote resources to encourage employees to help without any consideration of returns. In addition, the fairness perception of organizational practices – procedural justice and individual characteristics – are necessary to induce AHO and other OCB motives.Social implicationsThis research provides that the social implication of arousing the basic underpinning of driving OCB is altruistic motive and not egoistic. This finding helps to stimulate individuals to have more helping behaviors towards the organization.Originality/valueThis study provides solid evidence for the suggestion by the original proponents of OCB that the distinction between rewarded and unrewarded criterion is blurred in OCB literature. Our findings suggest that altruistic helping does exist and that this explains for a significant proportion of extra-role behavior.
fMRI neuromarketing and consumer learning theory
Authors: Hsu Melissa Yi-Ting , Cheng Julian Ming-Sung 
Published: February 2018

PurposeThe purpose of this paper is to examine the impact of gender on the neural substrates of theories on consumer behavior (i.e. the original compared with the revised versions of consumer learning [CL] theory) and to examine whether gender influences brain activation associated with word-of-mouth (WOM) communications (i.e. information specificity, source expertise and tie strength) after a product harm crisis. This article also discusses the WOM effects of product quality perception, negative emotion and purchase intentions by precise localizing brain activity.Design/methodology/approachThis study applied functional magnetic resonance imaging to measure brain activity (i.e. the blood oxygen level-dependent signal) during WOM communication after a product harm crisis.FindingsThe male participants treat the product quality as a constant and tend to support the original CL theory. The female participants, however, showed differentiable brain activation across three factors, suggesting a dynamic representation for product quality (i.e. not a constant), and they appear to be more sensitive to the revised CL theory.Originality/valueThis paper concluded that the original CL theory applies to males and the revised version applies to females. Therefore, gender determines whether the original or the revised version of the CL theory works in consumers’ decision-making, and the extant of research has not focused on the information after a product harm crisis in terms of whether the information being communicated is specific or tensile through WOM communication.
UAV attitude estimation based on the dual filtering methods
Authors: Zhuang Zhemin , Guo Zhijie , Joseph Raj Alex Noel , Guo Canzhu 
Published: February 2018

Purpose
A toy UAV performs tumbling, rolling, racing and other complex activities. It is based on low-cost hardware and hence requires a better algorithm to estimate the attitudes more accurately with low power consumption. The proposed technique based on optimized Madgwick filter and moving average filter (MAF) ensures improved convergence speed in estimating the attitude, achieves higher accuracy and provides robustness and stability of the toy UAV. The paper aims to discuss this issue.

Design/methodology/approach
Traditional methods are prone to problems such as slow convergence speed and errors in calculation of the attitude angles. These errors cause the vehicle to drift and tremble, thus affecting the overall stability of the vehicle. The proposed method combines the features of optimized Madgwick filter and MAF to provide better accuracy, achieved through the fusion of gyroscope and accelerometer data, and zero correction to eliminate the random drift error of the gyroscope and removal of high-frequency interference by MAF of the accelerometer data. The experimental results on actual flight data showed that the method was better than the conventional Madgwick and Mahony complementary filters.

Findings
The performance of the proposed method was analyzed by estimating the pitch and roll angles under the static and dynamic condition of the toy UAV. The results were compared with two traditional methods: Madgwick and Mahony complement filter. In the static condition, the variance and average error while estimating the attitudes was comparatively lower than the traditional method. For the dynamic conditions, the convergence time to achieve a prescribed swing angle was again lower than the traditional method. From these two experiments, it can be seen that the proposed method provides better attitude estimation at lower computation time.

Originality/value
The proposed method combines the optimized Madgwick filter and MAF to accuracy estimate the attitude of toy UAV. The algorithm mainly suits the toy UAVs which are based on low-cost hardware and require better control systems to ensure stability of the vehicle. The experimental results on real flight data illustrate that the method not only improves the convergence speed in estimating the attitude angle for large maneuvers of the toy UAV, but also achieves higher accuracy in the attitude estimation, thus ensuring the robustness and stability of the UAV.
UAV and obstacle sensing techniques – a perspective
Authors: Aswini N. , Krishna Kumar E. , Uma S.V. 
Published: February 2018

Purpose
The purpose of this paper is to provide an overview of unmanned aerial vehicle (UAV) developments, types, the major functional components of UAV, challenges, and trends of UAVs, and among the various challenges, the authors are concentrating more on obstacle sensing methods. This also highlights the scope of on-board vision-based obstacle sensing for miniature UAVs.

Design/methodology/approach
The paper initially discusses the basic functional elements of UAV, then considers the different challenges faced by UAV designers. The authors have narrowed down the study on obstacle detection and sensing methods for autonomous operation.

Findings
Among the various existing obstacle sensing techniques, on-board vision-based obstacle detection has better scope in the future requirements of miniature UAVs to make it completely autonomous.

Originality/value
The paper gives original review points by doing a thorough literature survey on various obstacle sensing techniques used for UAVs.
A matter of perspective – the role of interpersonal relationships in supply chain risk management
Authors: Durach Christian F. , Machuca José A.D. 
Published: February 2018

PurposeThe purpose of this paper is to, first, explore the role of interpersonal relationships between buying and supplying firms in the management of supply chain disruptions (SCDs). Interpersonal connections are proposed as “social lubricants” that can advance the knowledge about conventional interorganizational antecedents of firm resilience. Differentiating between high- and low-complexity manufacturing industries, the study then looks into how managers from these industry clusters can leverage the efficacy of these relationships through the appropriate use of interorganizational governance mechanisms.Design/methodology/approachStructural equation modeling is conducted with data collected from 229 manufacturing firms in Austria, Germany and Switzerland. Industry clusters are formed via a Q-sort exercise.FindingsResults support the assumption of a socially embedded, interpersonal dimension in buyer-supplier relationships that impact organizational-level resilience. It is suggested that investments in interpersonal skills and interpersonal complementarity are significant antecedents of both relational and re-deployable firm resilience. Surprisingly, no support was found for a positive impact of interpersonal information sharing on firm resilience, challenging findings from previous studies on an interorganizational level. Interorganizational governance and industry affiliation each have moderating effects on the performance of the resilience efficacy of interpersonal relationship antecedents, suggesting the existence of an important managerial lever.Originality/valueIntegrating the supply chain and behavioral science literature, this study is the first to investigate the interplay of interpersonal and organizational antecedents and their efficacy in the management of SCDs.
The governance of collaboration in complex projects
Authors: Chakkol Mehmet , Selviaridis Kostas , Finne Max 
Published: February 2018

PurposeInter-organisational collaboration is becoming increasingly important in complex projects; some project customers even formally require evidence of collaborative competence from potential providers. The purpose of this paper is to explore the governance of collaboration and the ways in which it is enacted in practice for complex projects.Design/methodology/approachThe study is based on a qualitative analysis of 29 semi-structured interviews, primary data from meetings and events supported by secondary data, including standards and industry-specific contract templates.FindingsThe paper identifies how collaboration can be effectively governed in complex projects through the emerging role of the collaboration standard and its impact on contractual and relational governance mechanisms. The standard sets higher-level institutional guidelines that affect the way in which collaboration is governed in complex projects. It helps formalise informal relational practices whilst also providing guidelines for building flexibility in contracts by including coordination- and adaptation-oriented provisions conducive to collaboration.Originality/valueThe paper demonstrates the emerging role of the collaboration standard and its influence on contractual and relational mechanisms deployed in complex projects. It shows how the standard can formalise and codify informal collaborative practices and help transfer related learning across projects, thereby contributing towards the dual requirement for standardisation and flexibility in project settings.
The role of the Troika on the Greek central government accounting reforms
Authors: Cohen Sandra , Karatzimas Sotirios 
Published: February 2018

PurposeThe purpose of this paper is to explore the role of the Troika’s advent played in the progress of the budgeting and the financial reporting systems reform at the Greek central government level.Design/methodology/approachThe approach of an extreme country case study is adopted. The data used in the paper have been identified through document analysis performed on the relevant documents produced by the Troika, the Greek Ministry of Finance, and other relevant sources. The reform process is seen through the lens of the neo-institutional theory and the resource dependency theory.FindingsAlthough both reforms targeted the introduction of best international practices – particularly useful in periods of financial distress and scarce resources – the advent of the Troika affected their progress and changed the priorities. As a result, the reform was redirected toward strengthening the cash budgeting system.Research limitations/implicationsThe study is subject to the limitations of an extreme case study research.Practical implicationsThis is a case where resource dependency changes political priorities and directions and affects the evolvement of state budget and accounting reforms under way.Originality/valueThe role of external fund providers in public sector financial management reform priority-setting, in the case of a developed Eurozone country, is analyzed. The study contributes to the research agenda on accounting practices in times of austerity.
Experimental investigation on the tribological properties of modified carbon nanotubes as the additive in castor oil
Authors: Qian Shanhua , Wang Hongyue , Huang Chuanhui , Zhao Yongwu 
Published: February 2018

Purpose
This paper aims to modify carbon nanotubes with oleic acid, and to study the tribological properties of castor oil with modified carbon nanotubes additives. The proper additives are sought for the future engineering application of castor oil.

Design/methodology/approach
Tribological properties of the castor oils mixed with the modified carbon nanotubes of four mass percentages were investigated using a four-ball testing rig. Coefficient of friction and wear scar diameter were obtained in each test, and the mechanism of modified carbon nanotubes and castor oil was discussed.

Findings
The results indicated that modified carbon nanotubes had better dispersion in castor oil. Coefficient of friction first increased, then decreased and finally grew stable with the time, and wear scar diameter of steel surface functioned as a first reduced then increased change with the additive mass percentage of modified carbon nanotubes. The minimum of average coefficient of friction and wear scar diameter occurred at 0.02 Wt.% modified carbon nanotubes.

Originality/value
A small amount of modified carbon nanotubes could improve properties of the castor oil, and the mixed castor oil with 0.02 Wt.% modified carbon nanotubes would be most possibly used in engineering applications.