bluuebunny/crossref_metadata_2025_split huggingface dataset:
An increase in paediatric arthroscopy in Europe: Experience of the EPOS Sport Study Group
Authors: Turati Marco , Crippa Marco , Nicolaou Nicolas , Tassistro Elena , Sinikumpu Jaakko , Courvoisier Aurelien , Mumme Marcus , Duart Julio , Thüsing Monika , Bigoni Marco , Accadbled Franck 
Published: November 2024

Purpose: Paediatric musculoskeletal injuries in association with increased participation in sports activities continue to increase. Arthroscopy is recognized as a safe and effective procedure in children. This study aims to identify trends in European paediatric sports centres over 20 years. Methods: A survey was performed across the European Paediatric Orthopaedic Society (EPOS) Sports Study Group focusing on 3 years (2000, 2009 and 2019). Centres were divided into two groups: Group 1 ( n = 5, with data for 2000, 2009 and 2019) and Group 2 ( n = 8, with data for 2009 and 2019). Data were analysed as the total annual number of cases and separately by anatomical region and patient demographics. A descriptive analysis was performed to characterize the trends. Results: Data from eight centres across Europe showed an increase in total annual arthroscopy cases (G1 from 53 to 202 and G2 from 393 to 615, p-value < 0.001) and as a percentage of paediatric orthopaedic surgeries (G1 from 1.6% to 5.2%; G2 from 5.1% to 6.8%) in seven out of eight centres. The knee remained the most commonly treated joint (G1 from 79.2% to 83.3%; G2 from 78.9% to 84.4%), despite the rise of others such as the elbow ( p-value = 0.020) and decline of the shoulder ( p-value = 0.014). Cases involving paediatric patients over 11 years increased while there was no gender distinction among paediatric patients. Conclusion: Paediatric arthroscopy procedures in Europe have increased in number over the past 3 decades. Technological advancements have allowed a surge in procedures and applications to new anatomical areas. Level of evidence: IV – retrospective database review.
The User-Centered Design of a Clinical Dashboard and Patient-Facing App for Gestational Diabetes
Authors: Kirkwood Jasmine R. , Dickson Jane , Stevens Marryat , Manataki Areti , Lindsay Robert S. , Wake Deborah J. , Reynolds Rebecca M. 
Published: November 2024

Background: The number of pregnancies affected by gestational diabetes mellitus (GDM) is growing. With the increased use of smartphones and predictive modeling, a mobile health (mHealth) solution could be developed to improve care and management of GDM while streamlining care through risk stratification. Methods: A user-centered mHealth tool was designed from ethnographic observations and 11 semi-structured interviews (six health care professionals [HCPs] and five women with GDM), followed by iterative changes and evaluation from three feedback groups with 31 participants (17 HCPs, 14 researchers) and 13 questionnaires with women with GDM. Results: “MyGDM” includes a clinical dashboard that centralizes the clinic’s patients, highlighting off-target blood glucose and predicting the need for pharmacological intervention. It is linked with a patient-facing app that includes structured education, culturally inclusive language options, and meal ideas. Through the feedback sessions, iterative changes were made around visualization and patient safety, and participants were positive toward the potential user experience. In the 13 questionnaires with women with GDM, 100% said it would fit into their lifestyle and help them manage GDM. Educational resources and the “request a call” functions were well received with 61.5% (8/13) and 69.2% (9/13) saying they were very likely or likely to use these, respectively. Conclusion: A user-centered mHealth tool consisting of a clinical dashboard linked with a patient-facing app for GDM care and management has been designed. Evaluation of the interactive design by end users was positive and showed that it met their needs.
Oral ibuprofen versus placebo in closure of patent ductus arteriosus in preterm neonates, a randomized control trial
Authors: El Sherif Dalia Fathi , El Raggal Nehal Mohamed , Nasef Marwa Waheed , Saleh Ghada Ahmad , Youssef Nada Hussein , Metwally Mohamed Hussein 
Published: November 2024

Background A consensus on treatment of patent ductus arteriosus (PDA) in preterm neonates remains elusive. Conservative management has recently gained popularity due to medical treatment lacking the evidence of benefit in terms of mortality and morbidity. Objective This study compares the efficacy of the standard dose of oral Ibuprofen versus placebo in the closure of PDA in preterm neonates ≤34 weeks gestation. Methods Eighty enrolled preterm neonates with a hemodynamically significant PDA (hsPDA) were randomized to either receive an early 3-day course oral ibuprofen or placebo (1:1). The open-label option and an extended oral ibuprofen therapy were offered if there were concerns over patient’s clinical condition being attributed to PDA and only if showing evidence of systemic and/or pulmonary hyperperfusion. Results No significant difference in PDA closure between both groups (62.5% vs 65% in Ibuprofen & placebo group respectively, p = .816). No significant difference was observed between groups in mortality ( p = 1), Bronchopulmonary dysplasia (BPD) ( p = 1), or necrotizing enterocolitis (NEC) (0.5). Placebo group required a longer duration of inotropic support (median of 10 vs 7.5 days in Ibuprofen group, p = .013) and were prescribed more diuretic therapy (27 vs 18 in Ibuprofen group, p = .043). Conclusion The standard dose of oral ibuprofen was comparable to placebo in early treatment of hsPDA in preterm neonates less than 34 weeks in terms of effect on ductal closure after one course of treatment, incidence of mortality, and morbidities like NEC, and BPD. Failure of ductal closure itself was associated in both groups with increased mortality, failure to reach full feeds, and more use of vasopressors and inotropes.
Serial VerifyNow P2Y12 platelet reactivity units in cerebral aneurysm patients treated with ticagrelor surrounding stent-coiling or flow diversion
Authors: Bielinski Tyler M. , Koul Prateeka , Collins Malie K. , Goren Oded , Weiner Gregory M. , Griessenauer Christoph J. , Schirmer Clemens M. , Hendrix Philipp 
Published: November 2024

Introduction Platelet function testing using serial VerifyNow P2Y12 platelet reactivity units (PRUs) is established for guiding clopidogrel antiplatelet therapy in cerebral aneurysm stenting procedures. However, for ticagrelor, the impact of serial PRU testing and the identification of safe PRU ranges remains unexplored. Methods Flow diversion stenting ( n = 232) and stent-assisted coiling procedures ( n = 83) performed 05/2017–12/2021 were reviewed. Out of these, 31 flow diversion and 18 stent-coiling procedures were performed on 44 patients using ticagrelor. Baseline demographics, ticagrelor PRUs, and clinical outcomes were assessed. Results Collectively, 257 ticagrelor P2Y12 PRUs were obtained. PRUs were <100 in 192/257 (74.7%) tests. Only 11/257 (4.3%) PRUs were >200. The overall median ticagrelor PRU was 38 (IQR 11–101). Among the 49 procedures, median PRUs before the procedure (25, IQR 10–67), on the day of the procedure (68, IQR 44–117), and on the day after the procedure (37, IQR 21–79) did not show the significant differences between the groups. A total of seven thromboembolic complications occurred. Median PRUs surrounding the thromboembolic complications (median 182, IQR 148–235) were significantly higher than preprocedural ( p < .001), day of surgery ( p < .01), and postprocedural PRUs ( p < .01). All seven procedures harbored demographic, anatomic, or procedural features increasing the risk for thromboembolic complications. Discussion The majority of periprocedural ticagrelor PRUs were <100. PRUs at the time point of thromboembolic complications were >120. Despite procedure-complicating features in each thromboembolic case, it raises the question whether safe ticagrelor PRU levels might be lower than those commonly applied for clopidogrel.
The techniques, efficacy and safety of penile glans augmentation using hyaluronic acid for the treatment of premature ejaculation: a systematic review and meta-analysis
Authors: Mohd Hashim Mohammad Hifzi , Md Zainuddin Zulkifli , Fam Xeng Inn , Khoo Hau Chun , Azizi Muhammad Hasif , Shukor Suzliza , Chin Kok-Yong , Iqbal Hussain Rizuana , Lim Li Yi 
Published: November 2024

Abstract
Background
Premature ejaculation (PE) is the most common self-reported sexual disorder among men, affecting up to 20% of the population. Recently, the injection of hyaluronic acid (HA) as a bulking agent into the glans of the penis was proposed as a promising modality for PE. It is believed to act as a barrier between the skin and nerve terminals, leading to decreased sensation of the glans penis, indirectly improving the outcome of PE. This scoping review aims to provide an overview of the techniques, efficacy, and safety of the injection of HA for PE derived from the existing scientific literature.

Main body
A literature search was conducted using PubMed, Scopus, and Web of Science databases and the keywords “hyaluronic acid” and “premature ejaculation.” Original articles were selected for further evaluation, while both case reports and case series were excluded. After the screening, ten relevant studies were included, with two main methods of injection, the Fanning technique and multiple puncture techniques, which were applied in the previous studies. All studies showed compelling improvements in both the intravaginal ejaculation latency time (IELT) and patients’ satisfaction. IELT increments may reach up to 8.54-fold even in the first month and sustain significantly up to 12 months. The complications reported, such as bleeding, pain, swelling, and discoloration, were mild and self-limited, which then resolved between 2 weeks and 1 month. No serious adverse events were reported.

Conclusions
With adequate surgical training and proper patient selection, penile augmentation using hyaluronic acid is a safe and effective method in the management of premature ejaculation.
Evolution of minimally invasive cholecystectomy: a narrative review
Authors: Nam Changjin , Lee Jun Suh , Kim Ji Su , Lee Tae Yoon , Yoon Young Chul 
Published: November 2024

Abstract
Background
Laparoscopic cholecystectomy, being a prevalent abdominal surgical procedure, has transitioned through various innovative stages aimed at reducing the procedure's invasiveness. These stages encompass Single-Incision Laparoscopic Cholecystectomy (SILC), Mini Laparoscopic Cholecystectomy (MLC), Natural Orifice Transluminal Endoscopic Surgery (NOTES), and Robotic-Assisted Laparoscopic Cholecystectomy (RALC). The purpose of this review is to trace the evolution of minimally invasive cholecystectomy techniques, assess their status, and identify emerging trends and challenges in the field.

Method
An extensive review was performed to explore the evolution and characteristics of SILC, MLC, NOTES, and RALC. The approach involved an in-depth examination of literature available on PubMed, coupled with a critical assessment of surgical outcomes, associated complications, and technical hurdles posed by these methods.

Results
SILC, despite its potential for reduced scarring, exhibits an elevated risk of bile duct damage and incisional hernia occurrences. MLC, mirroring the standard technique closely, presents minor benefits without amplifying postoperative complications, hence, positing itself as a feasible choice for routine elective cholecystectomy. NOTES, although still facing technical challenges, the hybrid transvaginal procedure is gaining clinical interest. RALC, heralded for its augmented precision and dexterity, emerges as a potential future avenue, although necessitating further exploration to ascertain its efficacy and safety.

Conclusion
The progression of laparoscopic cholecystectomy methodologies embodies the surgical society's aspiration to minimize invasiveness whilst enhancing patient outcomes. This review endeavors to offer a structured discourse on SILC, MLC, NOTES, and RALC, aspiring to aid the ongoing deliberation on the judicious selection of surgical techniques in clinical practice.
Fostering links, building trust, and facilitating change: connectivity helps sustain longitudinal integrated clerkships in small rural and remote communities
Authors: Carrigan Brendan , MacAskill William , Pinidiyapathirage Janani , Walters Sherrilyn , Fuller Lara , Brumpton Kay 
Published: November 2024

Abstract
Background
Maldistribution of medical professionals presents a significant challenge globally and leads to inequitable healthcare access, particularly in remote areas. Longitudinal integrated clerkships (LICs) in rural areas can improve workforce distribution and may be an innovative contributor to solving maldistribution issues. However, to align with healthcare needs, LICs must be sustainable in small communities, which often have a limited medical workforce. This study investigates the key elements underpinning LIC sustainability in small communities.

Methods
This study adopted a constructivist research paradigm in which participants’ constructions of their experiences supporting LICs in small rural communities were explored. Participants were conveniently sampled from the LIC community of practice attending the 2021 virtual annual conference of the Consortium of Longitudinal Integrated Clerkships. Data were collected through video recording and thematically analysed to identify barriers and enablers to running sustainable LIC programmes.

Results
Eleven participants fulfilling key roles within LICs, including clinical school directors, program coordinators, and clinical educators, were recruited for the study. Thematic analysis indicated that it is Connectivity, expressed through three subthemes, Fostering Links, Building Trust, and Facilitating Change, which underpins sustainable LICs in small communities.

Conclusions
Connectivity is a strong mediator for sustainability of LICs and may be the central defining theme of LICs. Increasing connectivity through prioritizing community engagement, trust-building, and strategic investment enhances the sustainability of rural LICs, ensuring their continued positive contribution to medical workforce distribution in underserved areas.
The use and impact of surveillance-based technology initiatives in inpatient and acute mental health settings: a systematic review
Authors: Griffiths Jessica L. , Saunders Katherine R. K. , Foye Una , Greenburgh Anna , Regan Ciara , Cooper Ruth E. , Powell Rose , Thomas Ellen , Brennan Geoff , Rojas-García Antonio , Lloyd-Evans Brynmor , Johnson Sonia , Simpson Alan 
Published: November 2024

Abstract

Background

The use of surveillance technologies is becoming increasingly common in inpatient mental health settings, commonly justified as efforts to improve safety and cost-effectiveness. However, their use has been questioned in light of limited research conducted and the sensitivities, ethical concerns and potential harms of surveillance. This systematic review aims to (1) map how surveillance technologies have been employed in inpatient mental health settings, (2) explore how they are experienced by patients, staff and carers and (3) examine evidence regarding their impact.

Methods
We searched five academic databases (Embase, MEDLINE, PsycInfo, PubMed and Scopus), one grey literature database (HMIC) and two pre-print servers (medRxiv and PsyArXiv) to identify relevant papers published up to 19/09/2024. We also conducted backwards and forwards citation tracking and contacted experts to identify relevant literature. The Mixed Methods Appraisal Tool assessed quality. Data were synthesised narratively.

Results
Thirty-two studies met the inclusion criteria. They reported on CCTV/video monitoring (n = 13), Vision-Based Patient Monitoring and Management (n = 9), body-worn cameras (n = 6), GPS electronic monitoring (n = 2) and wearable sensors (n = 2). Sixteen papers (50.0%) were low quality, five (15.6%) medium quality and eleven (34.4%) high quality. Nine studies (28.1%) declared a conflict of interest. Qualitative findings indicate patient, staff and carer views of surveillance technologies are mixed and complex. Quantitative findings regarding the impact of surveillance on outcomes such as self-harm, violence, aggression, care quality and cost-effectiveness were inconsistent or weak.

Conclusions
There is currently insufficient evidence to suggest that surveillance technologies in inpatient mental health settings are achieving their intended outcomes, such as improving safety and reducing costs. The studies were generally of low methodological quality, lacked lived experience involvement, and a substantial proportion (28.1%) declared conflicts of interest. Further independent coproduced research is needed to more comprehensively evaluate the impact of surveillance technologies in inpatient settings. If they are to be implemented, all key stakeholders should be engaged in the development of policies, procedures and best practice guidance to regulate their use, prioritising patients’ perspectives.
ASXL1 truncating variants in BOS and myeloid leukemia drive shared disruption of Wnt-signaling pathways but have differential isoform usage of RUNX3
Authors: Lin Isabella , Awamleh Zain , Sinvhal Mili , Wan Andrew , Bondhus Leroy , Wei Angela , Russell Bianca E. , Weksberg Rosanna , Arboleda Valerie A. 
Published: November 2024

Abstract
Background
Rare variants in epigenes (a.k.a. chromatin modifiers), a class of genes that control epigenetic regulation, are commonly identified in both pediatric neurodevelopmental syndromes and as somatic variants in cancer. However, little is known about the extent of the shared disruption of signaling pathways by the same epigene across different diseases. To address this, we study an epigene, Additional Sex Combs-like 1 (ASXL1), where truncating heterozygous variants cause Bohring-Opitz syndrome (BOS, OMIM #605039), a germline neurodevelopmental disorder, while somatic variants are driver events in acute myeloid leukemia (AML). No BOS patients have been reported to have AML.

Methods
This study explores common pathways dysregulated by ASXL1 variants in patients with BOS and AML. We analyzed whole blood transcriptomic and DNA methylation data from patients with BOS and AML with ASXL1-variant (AML-ASXL1) and examined differential exon usage and cell proportions.

Results
Our analyses identified common molecular signatures between BOS and AML-ASXL1 and highlighted key biomarkers, including VANGL2, GRIK5 and GREM2, that are dysregulated across samples with ASXL1 variants, regardless of disease type. Notably, our data revealed significant de-repression of posterior homeobox A (HOXA) genes and upregulation of Wnt-signaling and hematopoietic regulator HOXB4. While we discovered many shared epigenetic and transcriptomic features, we also identified differential splice isoforms in RUNX3 where the long isoform, p46, is preferentially expressed in BOS, while the shorter p44 isoform is expressed in AML-ASXL1.

Conclusion
Our findings highlight the strong effects of ASXL1 variants that supersede cell-type and even disease states. This is the first direct comparison of transcriptomic and methylation profiles driven by pathogenic variants in a chromatin modifier gene in distinct diseases. Similar to RASopathies, in which pathogenic variants in many genes lead to overlapping phenotypes that can be treated by inhibiting a common pathway, our data identifies common pathways for ASXL1 variants that can be targeted for both disease states. Comparative approaches of high-penetrance genetic variants across cell types and disease states can identify targetable pathways to treat multiple diseases. Finally, our work highlights the connections of epigenes, such as ASXL1, to an underlying stem-cell state in both early development and in malignancy.
Associations of perceived neighbourhood and home environments with sedentary behaviour among adolescents in 14 countries: the IPEN adolescent cross sectional observational study
Authors: Anjana Ranjit Mohan , Ranjani Harish , Cerin Ester , Akram Muhammad , Salmon Jo , Conway Terry L. , Cain Kelli L. , Pradeepa Rajendra , Barnett Anthony , Sit Cindy H. P. , Van Dyck Delfien , Hino Adriano Akira , Pizarro Andreia , Oyeyemi Adewale L. , Muda Wan Abdul Manan Wan , Moran Mika R. , Troelsen Jens , Mitáš Josef , Islam M. Zakiul , Queralt Ana , Mohan Viswanathan , Hinckson Erica , Sallis James F. 
Published: November 2024

Abstract
Background
Understanding environmental correlates of sedentary behaviour (SB) among young people is important as such data can identify approaches to limit sedentary time. This paper estimates associations of parent-reported neighbourhood and adolescent-reported home environments with SB among adolescents aged 11–19 years from 14 countries.

Methods
In the International Physical activity and the Environment Network (IPEN) Adolescent Study (an observational, cross-sectional multi-country study), adolescents wore a triaxial accelerometer for seven days that assessed sedentary time (ST). Adolescents completed survey measures of sedentary behaviour (SB) related to recreational screen time and sitting time in motor vehicles. Parents and adolescents completed surveys assessing neighbourhood and home environments. Accelerometer based ST was available in 3,982 adolescents while survey data were available for 6,302 dyads. We estimated the total and direct effects of each environmental attribute on ST and SB. Sex of the adolescent and city/country were examined as moderators.

Results
The average ST in adolescents from 14 countries ranged from 7.8 to 10.5 h/day. Personal social media was the only significant correlate of total ST across both sexes. With respect to self-reported SB, adolescents accumulated an average of 3.8 h of non-school screen time per day and nearly 40 min of transport-related sitting time. Screen time was associated with all home environment variables, including social media account, as well as land use mix—diversity, traffic safety, and crime safety. Transport-related sitting time was related to land use mix—diversity, recreation facilities, walking facilities, and pedestrian infrastructure, but no home environment variables. City/country and sex were significant moderators of several associations.

Conclusions
Both home and neighbourhood environment features were related to ST and SB. Having social media accounts emerged as a major contributor towards sedentarism in adolescents.