bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical significance of MYCN amplification in patients with high‐risk neuroblastoma
Authors: Lee Ji Won , Son Meong Hi , Cho Hee Won , Ma Young Eun , Yoo Keon Hee , Sung Ki Woong , Koo Hong Hoe 
Published: May 2018

AbstractBackgroundThis study investigated the clinical significance of MYCN amplification within high‐risk neuroblastoma (NB).MethodsMedical records of 135 patients who were diagnosed with high‐risk NB from 2004 to 2016 were reviewed.ResultsFifty‐one (38%) patients had MYCN amplified tumors, and the remaining 84 (62%) had nonamplified tumors. MYCN amplification was associated with abdominal primary site, less differentiated pathology, higher levels of lactate dehydrogenase and neuron‐specific enolase (NSE), lower vanillylmandelic acid level, and larger primary tumor volume at diagnosis. MYCN amplification was associated with a better early response (faster reduction of primary tumor volume and NSE level). The proportion of patients in complete response or very good partial response after induction treatment was relatively higher in MYCN amplified tumors than in nonamplified tumors; however, all progressions during induction treatment occurred only in MYCN amplified tumors (P = 0.007). The time to progression was shorter (median 1.5 years vs. 1.9 years, P = 0.037) and survival after relapse/progression was worse in MYCN amplified tumors (3 year overall survival: 7.7 ± 7.4% vs. 20.5 ± 8.8%, P = 0.046). There was no difference in event‐free survival and overall survival between MYCN amplified and nonamplified tumors.ConclusionMYCN amplification was associated with more aggressive features at diagnosis and a better early response, but a higher progression rate during induction treatment and lower chance of survival after relapse/progression. There was no difference in survival rates according to MYCN amplification in patients with high‐risk NB.
DIVERGT screening procedure predicts general cognitive functioning in adult long‐term survivors of pediatric acute lymphoblastic leukemia: A PETALE study
Authors: Boulet‐Craig Aubree , Robaey Philippe , Laniel Julie , Bertout Laurence , Drouin Simon , Krajinovic Maja , Laverdière Caroline , Sinnett Daniel , Sultan Serge , Lippé Sarah 
Published: May 2018

AbstractBackgroundAcute lymphoblastic leukemia (ALL) is the most common cancer in children. Because of major improvements in treatment protocols, the survival rate now exceeds 80%. However, ALL treatments can cause long‐term neurocognitive sequelae, which negatively impact academic achievement and quality of life. Therefore, cognitive sequelae need to be carefully evaluated. The DIVERGT is a battery of tests proposed as a screening tool, sensitive to executive function impairments in children and adolescent cancer survivors. Our study aimed at verifying the predictive value of the DIVERGT on general cognitive functioning in adult long‐term survivors of ALL.MethodsALL survivors completed the DIVERGT 13.4 years, on average, after remission (N = 247). In addition, 49 of these survivors (equally selected amongst those with low, average, and high DIVERGT scores) as well as 29 controls completed a more comprehensive neuropsychological evaluation within a 3‐year period from DIVERGT administration. Multivariate regression analysis was used to assess the predictive value of the DIVERGT on general intelligence, mathematics, verbal memory, and working memory. As a follow‐up analysis, three performance groups were created based on the DIVERGT results. Multivariate analysis of variance (MANOVA) assessed neuropsychological differences between groups.ResultsThe DIVERGT accurately predicted General Ability Index (GAI) (P < 0.0001), mathematics (P < 0.0001) and verbal memory (P = 0.045). Moreover, the low‐performance group consistently had poorer performance than the high‐performance and control groups on the neuropsychological tests.ConclusionThe DIVERGT is a useful, time‐effective screening battery for broader neurocognitive impairments identification in long‐term adult ALL survivors. It could be implemented as routine examination in cancer follow‐up clinics.
Poikiloderma with neutropenia in a Tunisian patient with a novel C16orf57 gene mutation
Authors: Sakka Rania , Mahjoub Bahri , Kerkeni Emna , Werdani Amina , Boussoffara Raoudha , Ben Cheikh Hassen , M'rad Ridha , Sfar Mohamed Taher 
Published: May 2018

AbstractPoikiloderma with neutropenia (PN) is a genodermatosis characterized by poikiloderma, permanent neutropenia, recurrent infections, nail abnormalities, and palmoplantar hyperkeratosis. We report the case of a Tunisian patient with PN. Skin lesions started from the face and spread to the extremities and trunk. Neutropenia was initially periodic and concomitant with infections periods. DNA analysis identified a novel homozygous deletion of a 1‐bp (c.161delC, p.P54RfsX60) in the C16orf57gene, presumed to be causative.This report presents the variability of the clinical manifestations and evolution of PN and emphasizes the importance of studying other patients with PN to better delineate mutations profile among populations.
Hematopoietic stem cell transplantation for sickle cell disease: Progress and challenges
Authors: Hulbert Monica L. , Shenoy Shalini 
Published: May 2018

AbstractSickle cell disease (SCD) presents challenges to hematopoietic stem cell transplantation (HSCT), including donor availability and morbidity with age/disease severity. However, severe SCD causes irreversible organ damage that HSCT can mitigate. This benefit must be balanced against preparative regimen toxicity, graft‐versus‐host disease, and mortality risk. We review efforts to balance HSCT complications with the promise of cure, and knowledge gaps that warrant further investigation. We highlight the burden of SCD, HSCT risks and benefits, and SCD families’ approach to this balance. We emphasize the necessity for information exchange to ensure a joint decision‐making process between providers and patients.
Nanocrystallisation of Ammonium DiNitramide (ADN) by Spray Flash Evaporation (SFE)
Authors: Berthe Jean‐Edouard , Schnell Fabien , Boehrer Yannick , Spitzer Denis 
Published: May 2018

AbstractAmmonium DiNitramide (ADN) is an interesting oxidizer to replace ammonium perchlorate in the composition of solid propellants. In this study, Spray Flash Evaporation (SFE) is presented as a new technology to enhance stability of ADN by crystallization of nanoparticles. The crystallinity and purity of the compound was confirmed by X‐Ray Diffraction and Raman analysis. An average diameter of spherical particles around 32 nm (solution of ethyl acetate) and 34 nm (solution of methyl acetate) was measured by Scanning Electronic Microscopy (SEM). Furthermore, the downsizing to nanoscale induces a slower moisture absorption kinetic under 55 % of relative humidity, a reduction of the critical diameter of detonation and the desensitization to impact.
Ultrasound and Ionic Liquid: An Ideal Combination for Organic Transformations
Authors: Kaur Gurpreet , Sharma Aditi , Banerjee Bubun 
Published: May 2018

AbstractCombination of ultrasound and suitable ionic liquid is a powerful tool to carry out diverse organic transformations. In many occasions, this fruitful combination helps to get the desire products without using any further catalysts even at room temperature. Recyclability of ionic liquid makes a protocol cost effective also. The present review deals with the ultrasound‐assisted organic synthesis in various ionic liquids either as catalyst or reaction media.
Rice Husk as the Source of Silicon/Carbon Anode Material and Stable Electrochemical Performance
Authors: Yu Kaifeng , Zhang Hanxiang , Qi Hui , Gao Xuan , Liang Jicai , Liang Ce 
Published: May 2018

AbstractHerein, a magnesiothermic reduction strategy is employed to synthesize three‐dimensional structured silicon/carbon (Si/C) material, using rice husk as raw materials. The composition and morphology of Si/C material are investigated by XRD, Raman, SEM and TEM. The unique structure benefits from the naturally conductive network of biomass carbon, and ensures the excellent electrochemistry performance. Utilizing for lithium‐ion batteries (LIBs) anode material, this Si/C composite behaves good cycling stability (537 mA h g−1 after 200 cycles at a current density of 0.1 A g−1), and enhanced rate capacity (640.31,521.6,415.88, and 331.71 mA h g−1 at current densities of 0.1, 0.2, 0.5 and 1 A g−1, respectively). Our research exhibits a new strategy for preparing low‐cost and environmental‐friendly Si/C material and possesses enormous potential to be extended to other biomass anode materials.
Urea and Ethylene Glycol‐Assisted Solvothermal Synthesis of Spheroidal LiFePO4/C Nanoparticles as a Cathode Material for Lithium‐ion Batteries
Authors: Wang Juan , Niu Yao , Fu Yonghong , Yang Yubing , Hojamberdiev Mirabbos 
Published: May 2018

AbstractSpheroidal LiFePO4/C nanoparticles were synthesized successfully via a urea and ethylene glycol‐assisted solvothermal synthetic route combined with high‐temperature calcinations under different solvothermal time and carbon coating amounts. The obtained samples were characterized with various techniques, including X‐ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and electrochemical performance experiments. The test results showed that urea as an additive plays a critical role in controlling morphologies of the final products and ethylene glycol as a stabilizer avoids the agglomeration of particles in the process. As a promising cathode material of lithium ion batteries, the LiFePO4/C in this work could provide an initiate discharge capacity of 155 mAh⋅g–1 and maintain 91.6% of initial capacity after 100 cycles at 0.1 C. The discharge capacity is 78.8 mAh⋅g–1 when circulating at high rate up to 10 C, showing excellent discharge performance. Furthermore, the in‐situ generated carbon ensures the higher electrical conductivity and the nano‐sized spheroidal LiFePO4/C particles prolong the cycle life of batteries, thus exhibiting high charge‐discharge capability, excellent rate properties and stable cycling behavior.
Impact of π Spacers on the Optical, Electrochemical and Photovoltaic performance of D‐(π‐A)2 Based Sensitizers
Authors: Sivanadanam Jagadeeswari , Ganesan Paramaguru , Gao Peng , Nazeeruddin Mohammad K. , Rajalingam Renganathan‐ 
Published: May 2018

AbstractA series of D‐(π‐A)2 organic dyes with different π spacers have been designed and synthesized. The modification of the bi‐anchoring dyes regarding π spacers assists in tuning the photochemical and electrochemical properties of the dyes, which determine the open circuit voltage (VOC), short circuit current density (JSC) and hence overall power conversion efficiency. It is found that varying the spacers has more influence on determining the short circuit current density of the solar cell devices made with these sensitizers. When thiophene is used as π spacer, higher short circuit current density of 9.42 mA/cm2 is observed. The better IPCE of the dye with thiophene as spacer further supports its advantage over other spacers. The observed tunable light harvesting property, electrochemical and photovoltaic behaviour by varying the π spacers in D‐(π‐A)2 type sensitizers will provide fruitful information for future designing of sensitizers with multi‐anchoring modes.
Syntheses, Crystal Structures and Properties of Two Novel Mixed Anion Hybrids with Formulas of Pb6O2(BO3)2(C2O4) and Pb4(CO3)2(C2O4)(OH)2
Authors: Yang Hui , Mao Feifei , Xu Cuixia 
Published: May 2018

AbstractIt has been regarded as an ideal strategy to design and synthesize new compounds by combining different functional groups together. Based on numerous experiments, it is successful to assemble two kinds of mixed anion groups together and obtain two novel mixed‐anion hybrids, namely, Pb6O2(BO3)2(C2O4) (1) and Pb4(CO3)2(C2O4)(OH)2 (2) under hydrothermal condition. In compound 1, three oxolead polyhedra share edges into a Pb3O6 cluster which is further connected by other four similar ones via corner‐sharing into 2D fluctuant square layers. BO3 units fill in the voids of oxolead layers into [Pb6O2(BO3)2]2+ layers which are connected by C2O42− anions into a 3D structure. Compound 2 displays [Pb4(CO3)2(OH)2]2+ layers which can be described as an alternating connection of [PbO6(OH)] and flat [CO3] triangles and are further linked by C2O42− anions into 2D Pb4(CO3)2(C2O4)(OH)2 layered framework. Photoluminescent investigations indicate that their emission spectra consist of several broad bands centered around 430, 620 nm and 450, 610, 720 nm for compounds 1 and 2, respectively. And interestingly, the intensity of the emission bands can be tuned through changing the excitation wavelengths.
Stereoselective Organocatalytic Synthesis of γ,γ‐Disubstituted Butenolides
Authors: Sharma Vivek , Bhardwaj Vimal K. , Chimni Swapandeep S. 
Published: May 2018

AbstractA direct highly diastereo‐ and enantioselective asymmetric doubly vinylogous 1,6‐Michael addition reaction of 3‐methyl‐4‐nitro‐5‐alkenyl isoxazoles with γ‐substituted deconjugated butenolides has been successfully developed with the help of Cinchona derived squaramides. This novel strategy has been utilized to synthesize a range of enantiopure γ,γ‐disubstituted butenolide molecules bearing remote contiguous quaternary and tertiary stereocenters in yield up to 76% with ee up to 98% and dr up to ≥20:1.
Parameter study of framed‐tube structures with outriggers using genetic algorithm
Authors: Chen Yue , Cai Kejian , Wang Xing 
Published: May 2018

SummaryIn this paper, the analysis of optimal locations of framed‐tube structures with outriggers is conducted with the uniform and nonuniform core and peripheral columns using genetic algorithm, aiming to minimize the interstory drift. Also, comparison and difference of the results between the uniform and nonuniform structures are carried out and discussed. Besides, several parameters which influence the behavior of the structure are identified and analyzed, such as different objective functions, segments of outriggers, thickness of core wall, stiffness of outriggers, and grade of concrete strength. In addition, a Matlab program is written to perform the parameter analysis of optimal location of outriggers. Take a 260‐m high‐rise building as a target building, the optimal locations of one to two sets of outriggers subjected to three kinds of horizontal loadings (uniform, parabolic, and triangular) are obtained and can be utilized for the structural preliminary design of tall buildings.
Impact of Appointment Waiting Time on Attendance Rates at a Clinical Cancer Genetics Service
Authors: Shaw Tarryn , Metras Julie , Ting Zoe Ang Li , Courtney Eliza , Li Shao‐Tzu , Ngeow Joanne 
Published: May 2018

AbstractThe increase in demand for clinical cancer genetics services has impacted the ability to provide services timeously. Given limited resources, this often results in extended appointment waiting times. Over the last 3 years, the Cancer Genetics Service at the National Cancer Centre Singapore has continued to experience a steady increase in demand for its service. Nevertheless, significant no‐show rates have been reported. This study sought to determine whether an association exists between appointment waiting times and attendance rates. Data was gathered for all participants meeting inclusion criteria. Attendance rates and appointment waiting times were calculated. The relationship between mean waiting times for those who did and did not attend their scheduled appointments was evaluated using Welch's t test and linear regression model. The results showed a significant difference in mean appointment waiting times between patients who did and did not attend (32.66 versus 43.50 days respectively; p < 0.0001). Furthermore, patients who waited for longer than 37 days were significantly less likely to attend. No‐show rates increased as the waiting time increased, at a rate of 19.60% per 20 days and 21.40% per 30 days. In conclusion, appointment waiting time is a significant predictor for patient attendance. Strategies to ensure patients receive an appointment within the necessary timeframe at the desired setting are important to ensure that individuals at increased cancer risk attend their appointments in order to manage their cancer risks effectively.
A shared identity promotes herding in an information cascade game
Authors: Berger Sebastian , Feldhaus Christoph , Ockenfels Axel 
Published: May 2018

AbstractOur research addresses the effect of shared vs. mixed group identities in an information cascade game. We vary whether subjects always choose after a decision maker who shares the same identity or after a decision maker with a different identity. We find that subjects’ inclination to follow their predecessor is stronger in groups uniquely consisting of ingroup members compared to mixed groups. We relate this result to recent social cognition research.
Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well‐characterized cohorts
Authors: Buckley Rachel F. , Mormino Elizabeth C. , Amariglio Rebecca E. , Properzi Michael J. , Rabin Jennifer S. , Lim Yen Ying , Papp Kathryn V. , Jacobs Heidi I.L. , Burnham Samantha , Hanseeuw Bernard J. , Doré Vincent , Dobson Annette , Masters Colin L. , Waller Michael , Rowe Christopher C. , Maruff Paul , Donohue Michael C. , Rentz Dorene M. , Kirn Dylan , Hedden Trey , Chhatwal Jasmeer , Schultz Aaron P. , Johnson Keith A. , Villemagne Victor L. , Sperling Reisa A. ,   on behalf of collaborators in the Alzheimer's Disease Neuroimaging Initiative,   the Australian Imaging, Biomarker and Lifestyle study of ageing,   the Harvard Aging Brain Study
Published: May 2018

AbstractIntroductionOur objective was to investigate the effect of sex on cognitive decline within the context of amyloid β (Aβ) burden and apolipoprotein E genotype.MethodsWe analyzed sex‐specific effects on Aβ‐positron emission tomography, apolipoprotein, and rates of change on the Preclinical Alzheimer Cognitive Composite‐5 across three cohorts, such as the Alzheimer's Disease Neuroimaging Initiative, Australian Imaging, Biomarker and Lifestyle, and Harvard Aging Brain Study (n = 755; clinical dementia rating = 0; age (standard deviation) = 73.6 (6.5); female = 55%). Mixed‐effects models of cognitive change by sex, Aβ‐positron emission tomography, and apolipoprotein ε4 were examined with quadratic time effects over a median of 4 years of follow‐up.ResultsApolipoprotein ε4 prevalence and Aβ burden did not differ by sex. Sex did not directly influence cognitive decline. Females with higher Aβ exhibited faster decline than males. Post hoc contrasts suggested that females who were Aβ and apolipoprotein ε4 positive declined faster than their male counterparts.DiscussionAlthough Aβ did not differ by sex, cognitive decline was greater in females with higher Aβ. Our findings suggest that sex may play a modifying role on risk of Alzheimer's disease–related cognitive decline.
Multinational enterprise buyers’ choices for extending corporate social responsibility practices to suppliers in emerging countries: A multi‐method study
Authors: Tong Xun , Lai Kee‐hung , Zhu Qinghua , Zhao Senlin , Chen Jianghang , Cheng T.C.E. 
Published: May 2018

AbstractWhen managing a global supply chain, one critical challenge encountered by multinational enterprises (MNEs) is the extension of corporate social responsibility (CSR) practices to suppliers in emerging countries. In this study, we use a multi‐method approach to explore 1) the nature of suppliers’ CSR heterogeneity based on the various components of CSR in emerging countries, and 2) the choices of MNEs for extending CSR to different types of suppliers in dynamic environments. We begin with a survey of Chinese original equipment manufacturers (OEMs) servicing MNEs to examine how these suppliers vary in CSR implementation based on cluster analysis results. To understand the choices made by MNE buyers for extending CSR to their OEM suppliers, we conduct an agent‐based simulation study considering the dynamics of a system with multiple agents (i.e., MNE buyers, OEM suppliers, and the government). The cluster analysis results show that CSR practices implemented by Chinese OEMs differ significantly from one another and can be classified into three clusters (i.e.,Leader,Follower,andLaggard). The simulation results provide insights into how the adaption costs (e.g., upgrade cost and cost saved by downgrading) and punitive (inspection with possible penalties) and supportive (subsidies) tactics adopted by the government affect the choices made by MNE buyers for extending CSR practices to suppliers in emerging countries. Moreover, we demonstrate when supportive tactics are more effective than punitive tactics under varying conditions and extend the model to investigate the consequences of switching between these two types of tactics in a sequential simulation.
Increased Risk of Incident Disease in Men with Peyronie’s Disease: Analysis of U.S. Claims Data
Authors: Pastuszak Alexander W. , Rodriguez Katherine M. , Solomon Zachary J. , Kohn Taylor P. , Lipshultz Larry I. , Eisenberg Michael L. 
Published: May 2018

Abstract

Background
The subsequent health risks associated with Peyronie’s disease (PD) are unknown.

Aim
This cohort study assesses the risk of developing auto-immune conditions and common chronic health conditions after a diagnosis of PD. We hypothesize that an increase in auto-immune disease will be evident in men with PD, as has been suggested in smaller studies.

Methods
We determined the longitudinal incidence of 13 auto-immune diseases and 25 common chronic conditions in a cohort from the Truven Health Analytics (Ann Arbor, Michigan, USA) database from 2007–2013. The cohort included men with 1 of 3 exposures in 2007: (1) men with PD, (2) men with erectile dysfunction (ED) but not PD, and (3) men without PD or ED, matched on age and follow-up duration.

Outcomes
To assess incidence, we utilized a Cox regression model adjusting for age, smoking, obesity, health care visits per year, urology visits per year, and years of follow-up.

Results
We included 8,728 men with PD; 204,147 men with ED; and 87,280 controls. Men with PD had an increased risk of developing benign prostatic hyperplasia (hazard ratio [HR] 1.21, 95% CI 1.16–1.27), prostatitis (HR 1.21, 95% CI 1.12–1.31), and lower urinary tract symptoms (HR 1.10, 95% CI 1.05–1.16) when compared to both men with ED and age-matched controls without ED or PD even when controlling for the number of urology visits per year. Compared to controls, men with PD also had an increased risk of developing keloids. No significant risk for any auto-immune disease was observed.

Clinical Implications
Clinicians should have heightened awareness for these relevant co-morbidities when treating men with PD.

Strengths & Limitations
Utilizing a claims database provides one of the largest cohorts of men with PD ever published but claims databases lack some individual patient data such as risk factors and demographic information relevant to PD, including: penile injury, history of urologic procedures, and other lifestyle factors.

Conclusion
Men with PD had a higher risk of benign prostatic hyperplasia, lower urinary tract symptoms, prostatitis, and keloids after a diagnosis of PD, but no increased risk of auto-immune conditions. These findings suggest a common etiology for these conditions that may manifest itself in diseases at different times in men’s life cycle.