bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity of native and alien freshwater bivalve species in Europe to climate‐related environmental factors
Authors: Collas Frank P. L. , Buijse Anthonie D. , Hendriks A. Jan , van der Velde Gerard , Leuven Rob S. E. W. 
Published: May 2018

AbstractWhile native freshwater bivalve species are declining, several alien bivalve species have become invasive, thereby impacting ecosystem functioning and services. These biodiversity changes can be attributed to deteriorated water quality, hydro‐morphological alterations, and the overarching effect of global change. Therefore, a systematic assessment of the sensitivity of freshwater bivalve species nowadays occurring in European inland waters to environmental factors is urgent. The present study reviewed 493 relevant papers, resulting in 8405 data entries on presence–absence of bivalve species in relation to environmental factors that are affected by global change (i.e., water temperature, water depth, oxygen availability, and flow velocity). From these worldwide field data, minimum and maximum values measured in their habitat and water bodies were selected. In addition, data on laboratory‐derived tolerance ranges were collected. Subsequently, novel species sensitivity distributions (SSDs) were derived for each environmental factor using field‐based occurrence data and laboratory‐derived tolerance ranges, respectively. Species sensitivity distributions for maximum habitat temperature significantly differed between native and alien species. The latter occurred in habitats with higher maximum water temperatures than native species. The increase in water temperatures by global warming will affect a higher percentage of native species than alien species. The ranking of species based on their sensitivity for various environmental factors shows that vulnerable and endangered species have a higher overall sensitivity and are likely to be more affected by climate change. Invasive alien species were found to have a lower overall sensitivity and are thus less affected by climate change further aiding to their invasive nature. The available SSDs allow the ranking of freshwater bivalve species sensitivity to environmental stressors, the prediction of their potential occurrence in freshwater habitats, and the evaluation of management measures to optimize their biodiversity and ecosystem services.
Clinical determinants of successful weaning from extracorporeal membrane oxygenation in patients with fulminant myocarditis
Authors: Matsumoto Manabu , Asaumi Yasuhide , Nakamura Yuichi , Nakatani Takeshi , Nagai Toshiyuki , Kanaya Tomoaki , Kawakami Shoji , Honda Satoshi , Kataoka Yu , Nakajima Seiko , Seguchi Osamu , Yanase Masanobu , Nishimura Kunihiro , Miyamoto Yoshihiro , Kusano Kengo , Anzai Toshihisa , Noguchi Teruo , Fujita Tomoyuki , Kobayashi Junjiro , Ishibashi‐Ueda Hatsue , Shimokawa Hiroaki , Yasuda Satoshi 
Published: May 2018

AbstractAimsPatients with fulminant myocarditis (FM) often present with cardiogenic shock and require mechanical circulatory support, including extracorporeal membrane oxygenation (ECMO) and ventricular assist device (VAD) implantation. This study sought to clarify the determinants of successful weaning from ECMO in FM patients.Methods and resultsWe studied 37 consecutive FM patients supported by ECMO as the initial form of mechanical circulatory support between January 1995 and December 2014 in our hospital. Twenty‐two (59%) patients were successfully weaned from ECMO, while 15 (41%) were not. There were significant differences in levels of peak creatine kinase and those of its MB isoform (CK‐MB), left ventricular posterior wall thickness (LVPWT), and prevalence of cardiac rhythm disturbances. Receiver operating characteristic curve analysis revealed that a peak CK‐MB level of 185 IU/L and LVPWT of 11 mm were the optimal cut‐off values for predicting successful weaning from ECMO (areas under the curve, 0.89 and 0.85, respectively). During the follow‐up [median 48 (interquartile range 8–147) months], 83% of FM patients who were weaned from ECMO survived, with preserved fractional shortening based on echocardiography. Of the 15 FM patients who were not weaned from ECMO, nine bridged to VAD, and only two were successfully weaned from VAD and survived.ConclusionsThese results indicate that myocardial injury, as evidenced by CK‐MB and LVPWT, and prolonged presence of cardiac rhythm disturbances are important clinical determinants of successful weaning from ECMO.
Impact of suggestion on the human experimental model of cold hyperalgesia after topical application of high‐concentration menthol [40%]
Authors: Helfert S. , Reimer M. , Barnscheid L. , Hüllemann P. , Rengelshausen J. , Keller T. , Baron R. , Binder A. 
Published: May 2018

AbstractBackgroundHuman experimental pain models in healthy subjects offer unique possibilities to study mechanisms of pain within a defined setting of expected pain symptoms, signs and mechanisms. Previous trials in healthy subjects demonstrated that topical application of 40% menthol is suitable to induce cold hyperalgesia. The objective of this study was to evaluate the impact of suggestion on this experimental human pain model.MethodsThe study was performed within a single‐centre, randomized, placebo‐controlled, double‐blind, two‐period crossover trial in a cohort of 16 healthy subjects. Subjects were tested twice after topical menthol application (40% dissolved in ethanol) and twice after ethanol (as placebo) application. In the style of a balanced placebo trial design, the subjects received during half of the testing the correct information about the applied substance (topical menthol or ethanol) and during half of the testing the incorrect information, leading to four tested conditions (treatment conditions: menthol‐told‐menthol and menthol‐told‐ethanol; placebo conditions: ethanol‐told‐menthol and ethanol‐told‐ethanol).ResultsCold but not mechanical hyperalgesia was reliably induced by the model. The cold pain threshold decreased in both treatment conditions regardless whether true or false information was given. Minor suggestion effects were found in subjects with prior ethanol application.ConclusionsThe menthol model is a reliable, nonsuggestible model to induce cold hyperalgesia. Mechanical hyperalgesia is not as reliable to induce.SignificanceCold hyperalgesia may be investigated under unbiased and suggestion‐free conditions using the menthol model of pain.
A novel affective–motivational‐based Overground System for detecting spinal cord injury‐associated thermal and mechanical hypersensitivity in rats
Authors: Dugan E.A. , Sagen J. 
Published: May 2018

AbstractBackgroundPreclinical research for neuropathic pain has depended primarily on the use of behavioural nociceptive testing that is sensory–discriminatory‐based and reflexive in nature. This can be particularly problematic in spinal cord injury (SCI)‐associated neuropathic pain research where hyperreflexia may develop thus confounding interpretation of reflexive responses as pain symptoms. To address this, we have designed an affective–motivational‐based Overground System that has interchangeable floors to allow examination of nociceptive behaviours in response to mechanical and cold stimuli prior to and following spinal cord injury.MethodsThe animals were pretrained for 3–4 weeks to cross three Overground System surfaces (cold, rough and neutral) at a consistent pace in order to obtain a food reward (Froot Loops™).ResultsFollowing SCI, crossing times were significantly decreased due to more rapid crossing over the cold surface despite forgoing of the food reward, in contrast with the sham control animals. This was correlated with the development of cold hypersensitivity as assessed by standard acetone droplet testing. In response to the rough surface, slower paced crossings (increased time to cross) were observed post‐SCI (also resulting in forgoing of the food reward), compared to pre‐SCI times and sham control animals. This was correlated with the development of mechanical hypersensitivity as assessed by standard von Frey testing.ConclusionsDifferent responses in crossing behaviour for the cold and rough surfaces suggest a precise adaptive change in decision‐making behaviour depending on the stimulus presented; thus, outcome measures may be easily tailored for different types of hypersensitivity symptoms.SignificanceWe have designed an Overground System that is easy to establish and addresses a major concern in preclinical pain research by providing a cognitive‐ and motivational‐based system for hypersensitivity detection. The affective–motivational‐based Overground System allows examination of pain‐like behaviours in response to cold (thermal) and rough (mechanical) stimulation prior to and following spinal cord injury. This system provides a more holistic and comprehensive assessment of nociceptive responses following SCI and helps overcome concerns of hyperreflexia confounding‐evoked behavioural outcome measures in SCI models. Further, the incorporation of cognitive and motivational components brings preclinical research closer to replicating the clinical experience of a patient's motivation to participate in rewarding lifestyle activities in relation to their pain.
Comparison and Scaling Effects of Rotational Micro‐Generators using Electromagnetic and Piezoelectric Transduction
Authors: Fu Hailing , Yeatman Eric M. 
Published: May 2018

AbstractRotational energy is widely distributed or easily acquirable from other energy sources (fluid flow, machine operation or human motion) in many industrial and domestic scenarios. At small scales, power generation from such rotational ambient sources can enable many autonomous and self‐reliant sensing applications. In this paper, three typical types of micro‐generators (energy harvesters), namely electromagnetic (EMREHs), piezoelectric resonant (PRREHs) and piezoelectric non‐resonant rotational energy harvesters (PNRREHs) are discussed and compared in terms of device dimensions and operation frequencies. Theoretical models are established for each type to calculate maximum achievable output power as a function of device dimension and operating frequency. Using these theoretical models, scaling laws are established for each type to estimate the achievable output. The EMREHs have a strong scaling effect both on device dimension (as L5) and on operating frequency (as ω2), whereas the PNRREHs are less so (L2.5ω0.5). PRREHs have a narrow band‐width as resonant harvesters, and are ideal for cases where the excitation frequency is constant. This study provides a guideline for selection and design of rotational energy harvesters (REH) when the device dimension and operating frequency are defined. The proposed scaling laws offer a convenient method to estimate the harvester performance for different dimensions and operating frequencies.
Origins of the Inverse Electrocaloric Effect
Authors: Grünebohm Anna , Ma Yang‐Bin , Marathe Madhura , Xu Bai‐Xiang , Albe Karsten , Kalcher Constanze , Meyer Kai‐Christian , Shvartsman Vladimir V. , Lupascu Doru C. , Ederer Claude 
Published: May 2018

AbstractThe occurrence of the inverse (or negative) electrocaloric effect, where the isothermal application of an electric field leads to an increase in entropy and the removal of the field decreases the entropy of the system under consideration, is discussed and analyzed. Inverse electrocaloric effects have been reported to occur in several cases, for example, at transitions between ferroelectric phases with different polarization directions, in materials with certain polar defect configurations, and in antiferroelectrics. This counterintuitive relationship between entropy and applied field is intriguing and thus of general scientific interest. The combined application of normal and inverse effects has also been suggested as a means to achieve larger temperature differences between hot and cold reservoirs in future cooling devices. A good general understanding and the possibility to engineer inverse caloric effects in terms of temperature spans, required fields, and operating temperatures are thus of fundamental as well as technological importance. Here, the known cases of inverse electrocaloric effects are reviewed, their physical origins are discussed, and the different cases are compared to identify common aspects as well as potential differences. In all cases the inverse electrocaloric effect is related to the presence of competing phases or states that are close in energy and can easily be transformed with the applied field.
Oligometastatic status as predictor of survival in metastatic human papillomavirus‐positive oropharyngeal carcinoma
Authors: Albergotti William G. , Abberbock Shira , Mathews Fasil , Ferris Robert L. , Johnson Jonas T. , Duvvuri Umamaheswar , Kim Seungwon 
Published: May 2018

AbstractBackgroundOligometastasis is a good prognostic indicator when compared to widely metastatic disease in malignancies of other organ systems. We hypothesized that oligometastasis in human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (SCC) would be associated with better overall survival.MethodsThis is a retrospective review of all HPV‐positive oropharyngeal SCC treated at one center with at least 1‐year of follow‐up. Patients were stratified into 2 cohorts: oligometastasis (1‐2 metastases, confined to 1 organ system) or polymetastasis (>2 metastases or multiple organ involvement) with cohorts compared for time to distant metastasis and overall survival after metastasis.ResultsThirty‐eight of 506 patients (7.5%) developed metachronous distant metastasis; 12 developed oligometastasis and 26 developed polymetastasis. Median overall survival after oligometastasis was significantly longer than polymetastasis at 45 months (95% confidence interval [CI] 19 months ‐ not reached) and 10 months (95% CI 5‐24 months; P = .00028).ConclusionOligometastasis in metastatic HPV‐positive oropharyngeal SCC portends a better prognosis than polymetastasis.
Treatment for T3 to T4a laryngeal cancer by open partial horizontal laryngectomies: Prognostic impact of different pathologic tumor subcategories
Authors: Succo Giovanni , Crosetti Erika , Bertolin Andy , Piazza Cesare , Molteni Gabriele , Cirillo Stefano , Petracchini Massimo , Tascone Martina , Sprio Andrea Elio , Berta Giovanni Nicolao , Peretti Giorgio , Presutti Livio , Rizzotto Giuseppe 
Published: May 2018

AbstractBackgroundThe purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes.MethodsFour hundred eighty‐nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility).ResultsFive‐year overall survival (OS), disease‐specific survival (DSS), disease‐free survival (DFS), locoregional, local control, freedom from laryngectomy, and laryngectomy‐free survival were significantly better in anterior tumors (subcategories I and III) when compared with the corresponding posterior ones (subcategories II and IV).ConclusionAnterior cT3 tumors are manageable by OPHL, and this approach could also be proposed in the treatment of early anterior cT4aN0. Despite promising results, OPHLs should be considered under investigation in posterior cT3 tumors due to clinical and biological behavior similar to cT4a tumors.
Helical intensity‐modulated radiotherapy with concurrent chemotherapy for oropharyngeal squamous cell carcinoma: A prospective investigation of acute swallowing and toxicity patterns
Authors: Moroney Laura B. , Helios Jennifer , Ward Elizabeth C. , Crombie Jane , Pelecanos Anita , Burns Clare L. , Spurgin Ann‐Louise , Blake Claire , Kenny Lizbeth , Chua Benjamin , Hughes Brett G. M. 
Published: May 2018

AbstractBackgroundConformal radiotherapy modalities may minimize treatment toxicities. The purpose of this study was to document the extent and timing of dysphagia and related toxicities during helical intensity‐modulated radiotherapy (IMRT) with chemotherapy for oropharyngeal squamous cell carcinoma (SCC).MethodsWe conducted a prospective study of 76 patients with oropharyngeal SCC undergoing helical IMRT with chemotherapy. Dysphagia and acute toxicity data were collected weekly during treatment and at 2, 4, and 12 weeks posttreatment using the Functional Oral Intake Scale, diet descriptors, and Common Terminology Criteria for Adverse Events (CTCAE) version 4.0.ResultsPatients experienced maximum incidence of grade 3 dysphagia (61%), mucositis (30%), and thick saliva (38%), with grade 2 xerostomia (87%) and dysgeusia (97%). Only 14.5% were nil‐by‐mouth. Symptoms peaked in week 7 and improved thereafter. Grade 3 dysphagia was twice as common for T3 to T4 tumors compared with T2.ConclusionResults confirm that patients with oropharyngeal SCC undergoing helical IMRT with chemotherapy continue to experience incidences of acute toxicities comparable with other conformal techniques, and need supportive cares.
Marsupialization of mandibular cystic ameloblastoma: Retrospective study of 7 years
Authors: Yang Zinan , Liang Qian , Yang Le , Zheng Guang‐sen , Zhang Si‐en , Lao Xiao‐mei , Liang Yu‐jie , Liao Gui‐qing 
Published: May 2018

AbstractBackgroundThis retrospective study investigated the reduction rate and speed of shrinkage after marsupialization in mandibular cystic ameloblastoma and clarified whether marsupialization is appropriate for unicystic ameloblastoma and multicystic ameloblastoma.MethodsSixty‐three patients with mandibular cystic ameloblastoma were initially treated with marsupialization. Premarsupialization and postmarsupialization panoramic radiographs were reviewed for reduction rate and speed of shrinkage, and then were evaluated with age, sex, tumor location, and tumor type.ResultsThe overall recurrence rate was 4.5% (2/44). The average reduction rate after marsupialization was 65.6%. No significant difference was found between unicystic ameloblastoma and multicystic ameloblastoma in reduction rate. The speed of shrinkage of unicystic ameloblastoma was significantly faster than that of multicystic ameloblastoma (P < .05). Similarly, patients with multicystic ameloblastoma had longer marsupialization periods than those with unicystic ameloblastoma (P < .05).ConclusionMarsupialization is effective in reducing tumor size for both unicystic ameloblastoma and multicystic ameloblastoma. Marsupialization plus second‐stage curettage is recommended as the primary treatment for mandibular cystic ameloblastoma.
Reuse of public, genome-wide, murine eosinophil expression data for hypotheses development
Authors: Grace Jillian O , Malik Astha , Reichman Hadar , Munitz Ariel , Barski Artem , Fulkerson Patricia C 
Published: May 2018

Abstract
The eosinophil (Eos) surface phenotype and activation state is altered after recruitment into tissues and after exposure to pro-inflammatory cytokines. In addition, distinct Eos functional subsets have been described, suggesting that tissue-specific responses for Eos contribute to organ homeostasis. Understanding the mechanisms by which Eos subsets achieve their tissue-specific identity is currently an unmet goal for the eosinophil research community. Publicly archived expression data can be used to answer original questions, test and generate new hypotheses, and serve as a launching point for experimental design. With these goals in mind, we investigated the effect of genetic background, culture methods, and tissue residency on murine Eos gene expression using publicly available, genome-wide expression data. Eos differentiated from cultures have a gene expression profile that is distinct from that of native homeostatic Eos; thus, researchers can repurpose published expression data to aid in selecting the appropriate culture method to study their gene of interest. In addition, we identified Eos lung- and gastrointestinal-specific transcriptomes, highlighting the profound effect of local tissue environment on gene expression in a terminally differentiated granulocyte even at homeostasis. Expanding the “toolbox” of Eos researchers to include public-data reuse can reduce redundancy, increase research efficiency, and lead to new biological insights.
Publicly archived eosinophil genome-wide expression data can be used to answer original questions, generate new hypotheses, and serve as a launching point for experimental design.
Radiation therapy patient education using VERT: combination of technology with human care
Authors: Jimenez Yobelli A. , Lewis Sarah J. 
Published: May 2018

AbstractThe Virtual Environment for Radiotherapy Training (VERT) system is a recently available tool for radiation therapy education. The majority of research regarding VERT‐based education is focused on students, with a growing area of research being VERT's role in patient education. Because large differences in educational requirements exist between students and patients, focused resources and subsequent evaluations are necessary to provide solid justification for the unique benefits and challenges posed by VERT in a patient education context. This commentary article examines VERT's role in patient education, with a focus on salient visual features, VERT's ability to address some of the spatial challenges associated with RT patient education and how to combine technology with human care.
Antagonistic activities of volatiles produced by two Bacillus strains against Monilinia fructicola in peach fruit
Authors: Liu Chang , Yin Xiaohui , Wang Qingguo , Peng Yong , Ma Yurong , Liu Pei , Shi Jingying 
Published: May 2018

AbstractBACKGROUNDBrown rot caused by Monilinia fructicola is one of most serious diseases of postharvest peach fruit. The objective of this study was to select effective antagonistic bacteria against Monilinia fructicola and evaluate the effects of these strains against brown rot.RESULTSFour bacterial strains producing inhibitory volatile gas against Monilinia fructicola were isolated from the peach rhizosphere soil. The volatiles produced by 12a (Bacillus vallismortis) and 14b (Bacillus altitudinis) showed considerable antagonistic activities. Monilinia fructicola showed 80.3% and 68.4% mycelial growth inhibition and cell damage in the presence of strains 12a and 14b, respectively. The inhibition rate of brown rot in peach fruit fumigated with the culture solution of 12a or 14b reached 77.1% and 50.0%, respectively. The volatile compounds produced by 12a and 14b were identified according to gas chromatographic–mass spectrometric analysis. Among them, 6‐methyl‐2‐heptanone and 2‐pentylfuran completely inhibited mycelial growth at 100 µL L−1 concentration. Cedrol showed strong inhibitory activity against mycelial growth at 100 µg L−1 and isodecyl methacrylate inhibited growth at high concentration. The inhibition rate of the 50 µL L−1 artificial mixture of these four volatiles was 59.3% in vitro.CONCLUSIONThese results indicate that the two antagonistic bacteria and some volatiles produced by them have potential value in controlling brown rot in harvested peach fruit. © 2018 Society of Chemical Industry