bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional well‐being and work engagement of nurses who moonlight (dual employment) in private hospitals
Authors: Engelbrecht Michelle , Rau Asta , Nel Petrus , Wilke Marisa 
Published: September 2019

AbstractBackground and aimGiven the myriad occupational stressors of nursing itself, plus the challenges of moonlighting, we aimed to investigate the emotional well‐being of moonlighting nurses and their work engagement. Well‐being was defined by levels of general health, mental health, emotional exhaustion, personal accomplishment, compassion satisfaction and compassion fatigue.DesignA cross‐sectional descriptive survey (December 2017 to March 2018) at private health care facilities in a Metropolitan Municipality, South Africa.MethodsTwo hundred and fifty‐one nurses completed self‐administered questionnaires, which comprised of validated scales.ResultsNurses were at low risk for emotional exhaustion (M=12.8; SD=11.23) and scored high on compassion satisfaction (M=42.34; SD=7.22) and work engagement (M=4.87, SD=1.18). Personal accomplishment (t= 2.535; P<.05) compassion satisfaction (t= 6.790; P=.000) and mental health (t=3.206; P<.05) made a statistically significant unique contribution to the prediction of work engagement. Nurses who had considered leaving the profession scored significantly higher on emotional exhaustion and compassion fatigue.ConclusionNurses who moonlighted in private health care facilities reported low risk for burnout and high levels of compassion satisfaction and work engagement. Further research is needed to explore the reasons for these findings. Attention must be given to ensuring the occupational well‐being of nurses in order to retain them in the profession.
A systematic review examining the effectiveness of medicines information services for patients and the general public
Authors: Williams Matt , Jordan Abbie , Scott Jenny , Jones Matthew D 
Published: September 2019

Abstract

Objectives
Hospital-based patient medicines helpline services (PMHS) and medicines information services for the general public (MISGP) are available in many countries to support people with their medicines. Our aim was to examine the available evidence regarding the effectiveness of PMHS and MISGP.

Methods
Searches were conducted using Medline, EMBASE, CINAHL, Scopus and Web of Science, on 11 August 2018. Forward and backward citation searches were conducted, grey literature was searched, and study quality/risk of bias was assessed. Findings were synthesised in a narrative synthesis. Where appropriate, weighted means were calculated.

Key findings
Thirty-two studies were identified for inclusion (17 published articles, 15 conference abstracts). Eighteen studies were conducted within the United Kingdom. Mean quality assessment was moderate (51%), and risk of bias was high (63%). PMHS and MISGP are both typically perceived as positive (e.g. 94% and 91% of participants were satisfied with using a PMHS and MISGP, respectively). For PMHS, the advice received is reported to be usually followed (94%, and 66% for MISGP). For both services, users report several positive outcomes (e.g. problems resolved/avoided, feeling reassured and improved health). PMHS may also be effective for correcting medicines-related errors (up to 39% of calls may concern such errors) and for potentially avoiding medicines-related harm (48% of enquiries concerned situations that were judged to have the potential to harm patients).

Conclusions
Findings suggest that both PMHS and MISGP may be beneficial sources of medicines-related support. However, the moderate quality and high risk of bias of studies highlight that more high-quality research is needed.
Long‐term symptomatic outcome after transurethral resection of the prostate: A urodynamics‐based assessment
Authors: Wada Naoki , Kikuchi Daiki , Tateoka Jo , Abe Noriyuki , Banjo Hiroko , Tsuchida Miyu , Hori Junichi , Tamaki Gaku , Kita Masafumi , Kakizaki Hidehiro 
Published: September 2019

ObjectivesTo examine the long‐term outcomes of transurethral resection of the prostate.MethodsWe retrospectively collected the data of patients who had undergone transurethral resection of the prostate before December 2010. Patients had been evaluated by urodynamics and the International Prostate Symptom Score preoperatively, and they were re‐evaluated by using the International Prostate Symptom Score at the minimum 7 years after transurethral resection of the prostate. Patients who received any treatments to improve voiding symptoms were defined as having a relapse of voiding dysfunction. The Schäfer nomogram was used to assess the degree of obstruction and detrusor contractility. We assessed the change in International Prostate Symptom Score over time depending on obstruction (Schäfer grade 3–6) versus no obstruction (Schäfer grade 0–2), and normal detrusor contractility (strong and normal) versus detrusor underactivity (weak and very weak). Relapse rates of voiding dysfunction were determined using the Kaplan–Meier method.ResultsA total of 39 patients were included. The mean age at transurethral resection of the prostate was 69.8 years, and the mean observation period after transurethral resection of the prostate was 114 months. During the observation period, eight patients (21%) were categorized as relapse of voiding dysfunction and the mean time to relapse was 4.2 years. Patients categorized as no obstruction or detrusor underactivity had a higher recurrence rate of voiding dysfunction with a statistical significance between those with versus without obstruction. Except for patients with relapse of voiding dysfunction, improvement of the International Prostate Symptom Score was maintained over a period of 10 years after transurethral resection of the prostate.ConclusionsFavorable long‐term symptomatic outcome after transurethral resection of the prostate is likely in patients with urodynamic obstruction. Patients without urodynamic obstruction are likely to have a relapse of voiding symptoms and require additional treatments in the long term.
Toughening of Li2O‐2SiO2 glass‐ceramics induced by intriguing deformation behavior of lithium disilicate nanocrystal
Authors: Deng Binghui , Luo Jian , Harris Jason T. , Smith Charlene M. , McKenzie Matthew E. 
Published: September 2019

AbstractWe report a toughening mechanism of Li2O‐2SiO2 glass‐ceramics induced by intriguing anisotropic deformation behavior of lithium disilicate nanocrystal under tensile loadings using molecular dynamics simulations. The nanocrystal undergoes clear brittle cleavage when loaded in the [010] direction, while exhibiting a first‐order deformation‐induced transition when loaded in the [100] direction. The transition is exclusively facilitated by local Li–O bond breaking, which spreads to the whole sample under continuous loading. This hierarchical deformation mechanism (exclusive Li–O bond breakage prior to any Si–O bond breakage) enables lithium disilicate nanocrystal bearing large amounts of deformation without breaking. We further demonstrate that the toughness of Li2O‐2SiO2 glass‐ceramics can be significantly enhanced by deliberate designs of nanocrystal distributions in glass. The direct observation of this intriguing deformation behavior might inspire new ideas to design tougher lithium disilicate glass‐ceramics.
LncRNA SNHG14 potentiates pancreatic cancer progression via modulation of annexin A2 expression by acting as a competing endogenous RNA for miR‐613
Authors: Deng Peng‐cheng , Chen Wei‐bo , Cai Hui‐hua , An Yong , Wu Xin‐quan , Chen Xue‐min , Sun Dong‐lin , Yang Yu , Shi Long‐qing , Yang Yong 
Published: September 2019

AbstractThis study aimed to determine long non‐coding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14) expression in pancreatic cancer and to explore the potential molecular actions of SNHG14 in mediating pancreatic cancer progression. Gene expression was detected by quantitative real‐time PCR. Cell proliferation, growth and invasion were detected by respective CCK‐8, colony formation, and transwell invasion assays. Protein levels were measured by Western blotting. Cell apoptosis and caspase‐3 activity were detected by flow cytometry and caspase‐3 activity assay. The link between miR‐613 and its targets was evaluated by luciferase reporter assay. In vivo tumour growth was evaluated using a xenograft model of nude mice. SNHG14 expression was up‐regulated in cancerous tissues from pancreatic cancer patients. High expression of SNHG14 was associated with poor tumour differentiation, advanced TNM stage and nodal metastasis. SNHG14 overexpression enhanced cell proliferative, growth and invasive abilities, and suppressed apoptotic rates and caspase‐3 activity in pancreatic cancer cells, while SNHG14 knockdown exerted opposite effects. Mechanistic studies revealed that miR‐613 was targeted by SNHG14, and Annexin A2 (ANXA2) was targeted and inversely regulated by miR‐613 in pancreatic cancer cells. In vivo studies showed that SNHG14 knockdown attenuated tumour growth. MiR‐613 was down‐regulated and ANXA2 was up‐regulated in the pancreatic cancer tissues, and SNHG14 expression levels were inversely correlated with miR‐613 expression levels and positively correlated with the ANXA2 mRNA expression levels. Collectively, our results suggest that SNHG14 potentiates pancreatic cancer progression through modulation of annexin A2 expression via acting as a competing endogenous RNA for miR‐613.
Association between depressive symptoms and sleep neurophysiology in early adolescence
Authors: Hamann Christoph , Rusterholz Thomas , Studer Martina , Kaess Michael , Tarokh Leila 
Published: September 2019

BackgroundDepression is highly prevalent among adolescents, and depressive symptoms rise rapidly during early adolescence. Depression is often accompanied by subjective sleep complaints and alterations in sleep neurophysiology. In this study, we examine whether depressive symptoms, measured on a continuum, are associated with subjective and objective (sleep architecture and neurophysiology) measures of sleep in early adolescence.MethodsHigh‐density sleep EEG, actigraphy, and self‐reported sleep were measured in 52 early adolescents (12.31 years; SD: 1.121; 25 female). Depressive symptoms were measured on a continuum using the Center for Epidemiological Studies Depression Scale (CES‐D). The association between depressive symptoms and 2 weeks of actigraphy, self‐reported sleep, sleep architecture, and sleep neurophysiology (slow wave activity and sigma power) was determined via multiple linear regression with factors age, sex, and pubertal status.ResultsDespite no association between polysomnography measures of sleep quality and depressive symptoms, individuals with more depressive symptoms manifested worse actigraphically measured sleep. Less sleep spindle activity, as reflected in nonrapid eye movement sleep sigma power, was associated with more depressive symptoms over a large cluster encompassing temporal, parietal, and occipital regions. Furthermore, worse subjectively reported sleep quality was also associated with less sigma power over these same areas. Puberty, age, and sex did not impact this association.ConclusionsSleep spindles have been hypothesized to protect sleep against environmental disturbances. Thus, diminished spindle power may be a subtle sign of disrupted sleep and its association with depressive symptoms in early adolescence may signal vulnerability for depression.
Non‐alcoholic fatty liver disease and the incidence of myocardial infarction: A cohort study
Authors: Sinn Dong Hyun , Kang Danbee , Chang Yoosoo , Ryu Seungho , Cho Soo Jin , Paik Seung Woon , Song Young Bin , Pastor‐Barriuso Roberto , Guallar Eliseo , Cho Juhee , Gwak Geum‐Youn 
Published: September 2019

AbstractBackground and AimNon‐alcoholic fatty liver disease (NAFLD) is a multisystem disease associated with an increased risk of cardiovascular disease (CVD), diabetes, and chronic kidney disease. Indeed, CVD is the most common cause of death in NAFLD patients. This study aimed to evaluate the association between NAFLD and the risk of incident myocardial infarction.MethodsThis is a retrospective cohort study involving 111 492 adults over 40 years old without history of CVD, liver disease, or cancer at baseline who participated in a regular health screening exam between 2003 and 2013. Fatty liver was diagnosed by ultrasonography.ResultsDuring 725 706.9 person‐years of follow‐up, 183 participants developed myocardial infarction (incidence rate 0.3 cases per 1000 person‐years). The age, sex, and year of visit‐adjusted hazard ratio (HR) for incident myocardial infarction comparing participants with NAFLD with those without it was 2.14 (95% confidence interval 1.59, 2.89). This association remained significant in fully adjusted models (HR 1.54; 95% confidence interval 1.11, 2.14). Compared with participants without NAFLD, in participants with low NAFLD fibrosis score (NFS) (< −1.455) and with intermediate‐to‐high NFS (≥ −1.455), the fully adjusted HRs for incident myocardial infarction were 1.70 (1.22, 2.36) and 1.88 (1.24, 2.87), respectively.ConclusionIn this large cohort study, NAFLD was associated with an increased incidence of myocardial infarction independently of established risk factors. In addition, this association was similar in participants with and without evidence of more advanced NAFLD as indicated by the NFS. NAFLD patients may need to be carefully monitored and managed early to prevent myocardial infarction.
Update on Research and Practices in Major Sleep Disorders: Part I. Obstructive Sleep Apnea Syndrome
Authors: Chaiard Jindarat , Weaver Terri E. 
Published: September 2019

AbstractPurposeThe purpose of this first of two review articles providing an update on sleep disorders was to examine the pathophysiology, epidemiology, and treatment of obstructive sleep apnea (OSA). OSA is a common sleep disorder whose prevalence is similar to asthma. As with other sleep disorders, OSA has a broad impact on individuals, affecting their daily behaviors, cognitive abilities, and performance, and putting them at increased risk for accidents, mood disorders, cancer, cardiovascular disease, and hypertension. Thus, early recognition and management, much of which can be implemented by nurses, can reduce health and accident risks and improve daily functioning.MethodsThis narrative review utilized medical databases such as PubMed to identify relevant English language original and systematic review articles predominantly from peer‐reviewed journals from 2012 to 2018. However, as background, findings from classic articles prior to 2012 were also included.Clinical RelevanceOSA is a common condition with considerable impact on daily functioning and potential for accidents and serious comorbidities such as hypertension, cardiovascular disease, diabetes, and depressed mood. The impairments and comorbidities associated with OSA can be reduced through early detection, encouraging treatment, providing education about sleep and OSA, and, importantly, promoting adherence to the predominant therapy, positive airway pressure.
Health and medical device development for fundamental care: Scoping review
Authors: Matinolli Hanna‐Maria , Mieronkoski Riitta , Salanterä Sanna 
Published: September 2019

AbstractBackgroundThe use of technology and health and medical devices as a part of fundamental nursing care is increasing. Although involving users in the device development process is essential, the role of nurses in the process has not yet been discussed.ObjectivesTo examine and map what kind of health and medical devices have been developed specifically for fundamental nursing care and to examine the design and development of the devices, particularly focusing on the role of nurses in the process.DesignScoping review.Data sourcesThe Medline, Cinahl, Web of Science, IEEE Explore and ACM DL databasesReview methodsThe databases were searched to identify studies describing health and medical devices developed for fundamental nursing care published between the years 2008–2018 in English language. References of included articles were reviewed for additional eligible studies. Two research team members screened the abstracts and full articles against the predefined inclusion and exclusion criteria. The PRISMA‐ScR checklist was used.ResultsOf the 7223 reports identified, a total of 19 were chosen for the scoping review. Of these, five were further analysed regarding the development process. Main focus areas of the included reports were patient monitoring, pressure ulcer prevention and patient transfer and mobility. Device development process, divided into three phases, was mainly driven by technological expertise and healthcare personnel were mainly involved in the evaluation phases.ConclusionsHealth and medical devices are a crucial part of the healthcare today and nurses are increasingly involved with their use. Most of the devices have been developed mainly by using technological expertise although they are directly aimed at fundamental aspects of nursing care. The results of our review suggest that the expertise of the nurses as the end‐users of the devices could be much more exploited.Relevance to clinical practiceA combination of expertise of device development from both nursing professionals and technical experts is necessary to disentangle the requirements of increased quality in nursing care combined with the ever‐growing technological requirements.
Occurrence, management and outcome of immune‐complex glomerulonephritis in dogs with suspected glomerulopathy in the UK
Authors: Vessieres F. , Cianciolo R. E. , Gkoka Z. G. , Kisielewicz C. , Bazelle J. , Seth M. , Adam F. H. , Matiasovic M. , Aresu L. , Jepson R. E. , Walker D. J. 
Published: September 2019

ObjectivesTo determine the proportion of dogs diagnosed with immune‐complex glomerulonephritis in a large cohort of UK dogs with clinical suspicion of glomerular disease in which renal histopathology, including routine light microscopy, transmission electron microscopy and immunofluorescence, had been performed. The second objective was to describe treatment and long‐term clinical outcome of dogs diagnosed with immune‐complex glomerulonephritis.Materials and MethodsSixty‐two UK dogs that underwent renal biopsies for investigation of suspected glomerulopathy (urine protein‐to‐creatinine ratio persistently >0.5) were included in this retrospective multicentre study. Signalment, clinico‐pathological abnormalities, histopathological diagnosis, treatment following diagnosis and survival were recorded.ResultsSeventeen (27%) of the dogs with suspected glomerular disease were diagnosed with immune‐complex glomerulonephritis and nine (53%) of these were still alive at the study end point, with a median follow‐up of 366 days (range 52 to 1299). Six dogs diagnosed with immune‐complex glomerulonephritis were treated with mycophenolate. Four received mycophenolate alone for immunosuppression and two received mycophenolate and chlorambucil; all these six dogs were alive at data collection [median follow‐up time 712.5 days (range 73 to 1299)]. Seven dogs diagnosed with immune‐complex glomerulonephritis did not receive immunosuppressive treatment; only one of these dogs was alive at study end point [median survival time 302 days (range 52 to 723)].Clinical SignificanceImmune‐complex glomerulonephritis may be less common in the UK than previously reported in North America and mainland Europe, reducing the likelihood of treatment modification following renal biopsy. Mycophenolate was the most commonly used immunosuppressant for cases of immune‐complex glomerulonephritis.
Parental anxiety regarding premature infants and factors affecting parental concern
Authors: Lee Ju Yun , Lee Jung Hyun , Yeon Gyu Min , Jung Yu Jin 
Published: September 2019

AbstractPurposePremature births have a great impact on the parents. The purpose of this study was to investigate the anxieties of parents of premature infants regarding infantile diseases and to help medical staff better communicate with parents of premature infants.Design and MethodsThis study included premature infants <37 weeks of age who were admitted to the Neonatal Intensive Care Unit of Kosin University Gospel Hospital between August 1, 2017, and December 31, 2017. The eligible subjects included 51 premature infants with their 75 parents (45 mothers and 30 fathers) listed in the children's medical records. Parental anxieties regarding the infants were determined by retrospective interviews at various time points as follows: before and after the birth, on postnatal Days 3 and 7, before discharge, in the first week after discharge, and at “whenever” time point.ResultsThe highest parental anxiety during all time points was regarding the respiratory system of the premature infants. Parental concerns regarding the metabolic–endocrine system of their infants significantly correlated with the presence of maternal diabetes mellitus. Parental anxiety significantly differed depending on the use of resuscitation after birth. A statistically significant difference in parental anxiety was observed in relation to the birth weight before discharge. The premature infants with bronchopulmonary dysplasia showed a significant difference in the level of parental anxiety concerning the infant's illness in the first week after discharge.ConclusionsThe parents of the premature infants were greatly concerned about their infants’ respiratory system. Careful prenatal counseling and support are needed for mothers with diabetes.
Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis
Authors: Le Sueur André Nanny Vieira , Geraldes Silvano Salgueiro , Melchert Alessandra , Takahira Regina Kiomi , Coyne Michael , Murphy Rachel , Szlosek Donald , Guimarães‐Okamoto Priscylla Tatiana Chalfun 
Published: September 2019

AbstractBackgroundSymmetric dimethylarginine (SDMA) is a methylated arginine derived from intranuclear methylation of l‐arginine by protein‐arginine methyltransferase and released into circulation after proteolysis. It is primarily eliminated by renal excretion, and its concentration is highly correlated with glomerular filtration rate (GFR) in animals and humans and is an earlier indicator of kidney dysfunction than serum creatinine concentration (sCr).ObjectivesTo evaluate and quantify the effects of IV fluid therapy (IF) or intermittent hemodialysis (IH) on renal function in a randomized group of dogs previously diagnosed with International Renal Interest Society (IRIS) stage 4 chronic kidney disease (CKD).AnimalsTwenty‐four client‐owned dogs with naturally occurring CKD.MethodsSerum from 14 dogs treated by IH and 10 dogs treated with IF was submitted for measurement of sCr and SDMA. Dogs in each treatment group received up to 5 treatment sessions, administered 48 hours apart.ResultsSignificant differences (P ≤ .05) were seen between treatment groups, but dogs from the IH group were the most affected based on SDMA (P < .001), sCr (P < .001), and blood urea (P < .001) concentrations. Furthermore, for each 10% increase in urea reduction ratio, there was a 6.2 μg/dL decrease in SDMA (P = .002).Conclusions and Clinical ImportanceAlthough SDMA is dialyzable biomarker and despite its removal by IH, SDMA correlates better with renal function than does sCr in dogs with CKD undergoing IF and IH.