bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new approach in cardioverter-defibrillator implantation in patients with coronary artery disease
Authors: Atabekov Т. A. , Batalov R. E. , Krivolapov S. N. , Sazonova S. I. , Khlynyn M. S. , Levintas A. D. , Popov S. V. 
Published: April 2019

Aim.Defibrillation lead implantation technique optimization using cardiac scintigraphy in patients with coronary artery disease (CAD).Material and methods.In this study 81 patients (male — 72, age 64,0±8,7 years with CAD and indications for the cardioverter-defibrillator (ICD) implantation were examined. Patients were divided into two groups. In 1-st group before ICD implantation, patients underwent cardiac 99mTc-methoxy-isobutyl-isonitrile scintigraphy for right ventricle wall perfusion disorders assessment. In this group defibrillating lead was implanted to the septal position, if the perfusion disorders were in the apical segments, and to the apical position, if perfusion disorders were in the septal segment. In 2-nd group lead was implanted using conventional approach. Defibrillating lead parameters (threshold, sense, impedance and shock impedance on 1-st, 7-th, 30-th and 180-th follow-up days) were compared.Results.The 1-st group consisted of 45 (55,5%) patients (male — 41, age 62,2±8,8 years). In 28 (62,2%) cases in this group defibrillating lead was implanted to the apical and in 17 (37,8%) — to the septal position. The 2-nd group consisted of 36 (44,5%) patients (male — 31, age 66,3±8,2 years; p=0,03). In 20 (55,5%) cases in this group defibrillating lead was implanted to the septal and in 16 (44,5%) — to the apical position. There were significant differences between groups in terms of: threshold and sense at all follow-up days (p=0,0001) and impedance on 1-st (p=0,003), 30-th (p=0,0001) and 180-th day (p=0,002), respectively.Conclusion.Assessment of right ventricular perfusion before ICD implantation can reduce threshold and raise sense, thereby prolong the ICD longevity and improve life-threatening ventricular tachyarrhythmia detection in the early and long-term period in patients with CAD.
Renal function and non-coronary atherosclerosis progression in patients with coronary artery disease one year after coronary artery bypass
Authors: Bezdenezhnykh A. V. , Sumin A. N. , Bezdenezhnykh N. A. , Kazachek Ya. V. , Barbarash O. L. 
Published: April 2019

Aim.To study associations of the estimated glomerular filtration rate (eGFR) with non-coronary atherosclerosis progression criteria and risk factors one year after coronary bypass surgery (CABG).Material and methods.Of the 732 patients consecutively operated (586 men and 146 women, median age 59 years), 504 people visited the study center 1 year after CABG. At the preoperative and annual stages, all patients were assessed with the same set of clinical, instrumental and laboratory methods, and the ankle-brachial index (ABI) was measured. The eGFR was calculated by the CKD-EPI formula. Depending on the severity of non-cardiac arterial stenoses, the following groups were identified: <30%; 30-49%; 50-69%; 70-99%; occlusion; absence of stenosis. The criteria for the atherosclerosis progression was the presence of at least one of the following: the transition of stenosis from one group to another; decrease in initially normal ABI <0,9; decrease in ABI initially abnormal (<0,9) by more than 10%. For the analysis, two groups were identified: group 1 (n=375) without progression and group 2 (n=129) with progression of atherosclerosis.Results.Preoperatively, the number of patients with eGFR <60 ml/min/1,73 m2 was equal in both groups. At both control points, eGFR was higher in 1 group (p=0,072 and 0,025, respectively). During the year, eGFR increased in both groups with significant differences among first one (p<0,001). One year after the operation, eGFR positively correlated with ABI (p=0,004) and with total and low-density lipoprotein cholesterol levels. Polyvascular disease determined from 30% of stenosis, was negatively associated with preoperative and annual eGFR (p=0,011 and p=0,004, respectively) and from 50% — with eGFR calculated one year after CABG (p=0,006).Conclusion.In patients with progression of non-coronary atherosclerosis 1 year after CABG CKD-EPI eGFR was lower compared to patients without progression. In the long-term period the estimated values of renal function are significantly higher in patients without atherosclerosis progression.
Comparative assessment of kidneys’ functional state in patients with acute coronary syndrome
Authors: Balashkevich N. A. , Dyusenova L. B. , Zhetpisbaev B. A. , Kazymov M. S. , Izbasarova I. A. , Borovikova O. A. , Shalgumbaeva G. M. 
Published: April 2019

Aim.To determine the severity of chronic kidney disease (CKD) in patients after acute coronary syndrome (ACS).Material and methods.The study was conducted in Semey (Semipalatinsk), East Kazakhstan region. The case histories of patients with ACS who were admitted to the University Hospital of the State Medical University (Semey State Medical University) of the East Kazakhstan Region for 1 year were studied. A total of 659 case histories were analyzed, of which 263 were patients with myocardial infarction (MI), and 396 were patients with unstable angina (UA). The diagnostic criteria for CKD were: proteinuria, levels of creatinine, glomerular filtration rate (GFR) <60 ml/min/1,73 m2. CKD stage was determined by the parameters of GFR.Results.The average proteinuria in patients with MI (Me=0,033) were higher than in patients with UA (Me=0,00), U=39564,5, Z=-5,579 p=0,000. The average values of creatinine in patients with MI were 10,26 mmol/l higher than in patients with UA (t=3,333, df=657, p=0,001). The mean GFR values in patients with MI were lower by 4,69 L/min/1,73 m2 than in patients with UA (t=-3,794, df=657, p=0,000. The highest percentage of CKD in patients with ACS were in stage 2-3, the second stage of CKD was more often diagnosed in patients with UA.Conclusion.The results of study allowed us to characterize the severity of CKD in patients undergoing ACS. We consider that widespread introduction of international and national clinical guidelines on the diagnosis, treatment and prevention of CKD in patients undergoing ACS is needed.
Noninvasive assessment of the fractional reserve of coronary blood flow with a one-dimensional mathematical model. Preliminary results of the pilot study
Authors: Gognieva D. G. , Gamilov T. M. , Pryamonosov R. A. , Vasilevsky Yu. V. , Simakov S. S. , Liang F. , Ternovoy S. K. , Serova N. S. , Tebenkova E. S. , Sinitsyn E. A. , Pershina E. S. , Abugov S. A. , Mardanyan G. V. , Zakryan N. V. , Kirakosyan V. R. , Betelin V. B. , Mitina Yu. O. , Gubina A. Yu. , Shchekochikhin D. Yu. , Syrkin A. L. , Kopylov F. Yu. 
Published: April 2019

Aim.To evaluate the diagnostic accuracy of a noninvasive method of fractional flow reserve (FFR) assessment based on a one-dimensional hemodynamic model build on data obtained from the coronary computed tomography angiography (CCTA).Material and methods.The study enrolled 57 patients: 16 of them underwent 64-slice computed tomography — included retrospectively, 34 — prospectively, with a 640-slice CT scan. Specialists from the Laboratory of Mathematical Modeling processed CT images and evaluated noninvasive FFR. Ischemia was confirmed if FFR <0,80 and disproved if FFR ≥0,80. After that the prospective group of patients was hospitalized for invasive FFR assessment as a reference standard; if ischemia was proved, patients underwent stent implantation. In the retrospective group, patients already had invasive FFR values estimated. Statistical analysis was performed using R programming language packages (cran-r.project.com). Continuous variables are presented as mean values ± standard deviations, order variables are presented as medians with interquartile ranges in parentheses. We used the D’Agostino-Pearson omnibus test for the assessment of normality of distribution; a Q-Q Plot was also constructed. We performed the Bland-Altman analysis and ROC-analysis for comparison of these two methods, and the Pearson’s chi-squared to assess the degree of correlation.Results.During data processing, 3 patients of the retrospective and 34 patients of the prospective group were excluded from the study. The sensitivity of our method was 90,91% (95% CI; 58,72-99,77), specificity — 86,67% (95% CI; 59,54-98,34), P<0,05, accuracy — 88,46 (95% CI; 69,85-97,55) — in per-vessel analysis. In perpatient analysis, the sensitivity was 91,67% (95% CI; 61,52-99,79), specificity — 80% (95% CI; 28,36-99,49), (P<0,05); accuracy 88,24 (95% CI; 63,56-98,54).Conclusion.Our method has quite a high accuracy and can be successfully used in clinical practice in order to enhance the diagnostic efficiency of the CCTA.
Possibilities of magnetic resonance imaging in predicting of the critical reduction of left ventricle contractile function in patients with coronary artery disease after direct myocardial revascularization
Authors: Kryukov N. A. , Ryzhkov A. V. , Sukhova I. V. , Ananyevskaya P. V. , Fokin V. A. , Gordeev M. L. 
Published: April 2019

Aim.To identify the criteria for reversibility of structural changes in the myocardium of patients with coronary artery disease after revascularization based on analysis of data obtained using magnetic resonance imaging (MRI).Materials and methods.We studied the long-term results of surgical treatment of 53 patients with critical reduction of left ventricle contractile function (ejection fraction less than 30%) undergoing coronary bypass surgery. Before the operation, all patients underwent cardiac MRI and transthoracic echocardiography (EchoCG). Immediate and long-term results were assessed according to EchoCG.Results.The average observation period was 25,0±15,4 months. We found that significant predictors of improving of left ventricle contractile function are diastolic interventricular septum thickness (according to EchoCG and MRI) >10,5 mm (p<0,05); diastolic posterior wall thickness (according to EchoCG and MRI) >9,5 mm (p<0,05); degree of initially scarred myocardium according to MRI <33 points (p<0,05).Conclusion.Detection of a viable myocardium is a prognostically important sign of a possible improvement in the functional state of left ventricle after revascularization surgery in patients with coronary artery disease, complicated by a critical reduction of myocardium contractile function. Thus, this problem can be solved by contrasting MRI.
Прогнозирование развития прикладной психологии как проблема историко-психологических иследований
Authors: Носкова Ольга Геннадьевна 
Published: April 2019

<p>В статье рассматривается проблема прогнозирования актуальных тем прикладной психологии на основе интерпретации содержания задач представителей новых профессий, профессий будущего. Объектом изучения стали материалы книги «Атлас новых профессий» (М., 2015), подготовленные специалистами-непсихологами, наметившими перспективные сферы профессиональной деятельности в рамках 25 ключевых отраслей экономики.</p>
Study of management of postpartum hemorrhage and its complications
Authors: Thawal Yogesh , Kolate Dipak S. , Patvekar Meenal M. , Jindal Shikha , Deshpande Hemant , Bhola Amrita 
Published: April 2019

Background: Postpartum hemorrhage (PPH) is globally one of the most common causes of maternal death, especially in developing country like India. Pregnancy and childbirth involve significant health risks, even to women with no preexisting health problem. The objective of this study was to analyze the role of various interventions in the management of PPH and its complications.Methods: This prospective observational study was conducted in the department of obstetrics and gynecology of Department of Obstetrics and Gynecology, Dr. D Y Patil Medical college, Pimpri, Pune, Maharashtra, India. A total number of 80 cases of postpartum hemorrhage that fulfilled the selection criteria were included. Data collected and analyzed in PPH patients with medical and surgical management.Results: In present study, most of cases were multigravida (60%) and more than 50 percent of patients required blood and blood products. In present study, most of the postpartum bleeding or postpartum hemorrhage (PPH) cases managed by medical methods. Uterotonic drugs (42.5%) This was possible due to early identification and timely intervention.Conclusions: Active management of third stage of labour is recommended in all cases. Seventy percent cases were managed by medical methods while rest of the cases required surgical management. Among the medical management uterotonic drugs and bimanual uterine compression was used while among the surgical methods repair of cervical and vaginal laceration was mostly required.
Improvement in radiographic quality workflow due to use of digital imaging and picture archiving and communication system
Authors: Wani Abdul Haseeb , Parry Arshed Hussain , Khanday Shakeel Ahmad , Gojwari Tariq Ahmad 
Published: April 2019

Background: PACS (Picture archiving and communication systems) and digital imaging (DI) has revolutionized radiology bringing about a paradigm shift in the way radiodiagnosis is perceived and practiced with a slew of benefits like elimination of the need for manual handling of films, helping in long term storage of digital images, easy transfer and retrieval of radiographic images. The objective of this study was to analyse the influence of PACS and digital imaging on the workflow in the radiology, performance of the radiographer and image storage and retrieval capabilities.Methods: It was a questionnaire-based study in which questions were asked to the radiographers working in our hospital at five different working sites. Each questionnaire was aimed to evaluate the effect of digital imaging on radiology workflow, improvement in the performance of radiographers, reduction in the work-related frustration levels due to use of digital imaging and finally the utility of digital imaging in image storage, query and retrieval.Results: Among the 50 questionnaires 41 were completed and retrieved. Among the respondents, 90.24% indicated that digital imaging has obviated the need for repeat examinations, 95.12% agreed with the fact that it resulted in the reduction of the number of reject images, 95.1% said it helped them in improving their performances, 92.6% of the respondents said they did not face any issue with its use and 95.1% of the participants agreed that the image query and retrieval could be accomplished in a hassle-free manner.Conclusions: The digital imaging technique not only improves the performance of the radiographers but also increases the workflow of the health care hospitals or clinics. The digital imaging reduces the number of rejected images thus reducing radiation exposure to the patients. Further, it is highly cost-effective and time-saving.
Evaluation of the Severity and Duration of Thrombocytopenia following Exchange Transfusion in neonatal hyperbilirubinemia
Authors: Boskabadi Hassan , Mir Mahdie 
Published: April 2019

Background: Infant jaundice is one the most common causes of hospitalization in infant in the first month of birth, which is defined an abnormal increase in blood bilirubin levels. Exchange transfusion is the recommended treatment for neonatal jaundice who do not respond to phototherapy and experience dangerous complication of jaundice and signs of kernicterus. However, this treatment may lead to complications such as thrombocytopenia. This study aimed to investigate the severity and duration of thrombocytopenia following the exchange transfusion in neonatal jaundice.
Material and Methods: This cross section study was performed on 217 infants. Infants with a gestational age of 35 to 42 weeks and bilirubin levels of above 17 mg/dl, who were undergoing treated with exchange transfusion, entered in this study. This study was conducted from 2012 to 2018 in the Ghaem Hospital (Mashhad, Iran). The samples were selected by convenience sampling. The platelet count was measured before exchange transfusion, right after exchange transfusion, 6 hours after exchange transfusion, and platelet count continued until platelet level was normal. At the time of discharge, platelet levels were re-measured.
Results: Among the samples, 104(53.8%) were males and 89 (46.2%) females. Of the infants who were transfused, 15 % had thrombocytopenia. After the exchange transfusion, 80 % of infants had thrombocytopenia. The mean platelet count before the exchange transfusion was 299,180 per mm3 of blood, and it was 105.140 per mm3 of blood after the exchange transfusion. With respect to severity of this complication, 86 % of the thrombocytopenia after exchange transfusion was mild to moderate.
Conclusion: In this study, nearly one-sixth of the infants who needed exchange transfusions had thrombocytopenia that most of them had platelet of more than 100000. Thrombocytopenia is associated with jaundice and can be exacerbated by phototherapy.
Induced pluripotent stem cells (iPSCs) based approaches for hematopoietic cancer therapy
Authors: Khandany Bardia , Heidari Mohammad Mehdi , Khatami Mehri 
Published: April 2019

Induced pluripotent stem cells (iPSCs) are reprogrammed from somatic cells through numerous transcription factors. Human induced pluripotent stem cell approaches are developing as a hopeful strategy to improve our knowledge of genetic association studies and the underlying molecular mechanisms. Rapid progression in stem cell therapy and cell reprogramming provides compelling reasons for its feasibility for treating a wide range of diseases through the replacement of autologous cells. Continuous failure in embryonic stem cells (ESC) production and the dependency of iPSC on ectopic genes may be due to the inability to maintain the stability of the endogenous gene systems which are essential for creation of pluripotency state. With recent developments in the genome processing and human tissue culturing approaches as well as xenotransplantation, bioengineering, and genome editing, induced pluripotent stem cells offer the new opportunities for the study of human cancers. Most hematopoietic malignancies are originated from cells that are functionally heterogeneous and few of them are responsible for maintaining tumor state. The naming of these cancer stem cells are due to the quality characteristics of normal tissue stem cells, such as self-renewal, long term survival, and the ability to produce cells with more differentiated properties. The aim of present study was to focus on the recent progresses in the application of stem cell-based hematopoietic cancer, and to assess the benefits of treatment, opportunities, and shortcomings that can potentially help improve future efforts in experimental and clinical studies.
PARENTING BEHAVIOR OF HEARING IMPAIRED PARENTS
Authors: Antawati Dewi Ilma , Nurdibyanandaru Duta 
Published: April 2019

Purpose of Study: The purpose of this study is to explain the parenting behavior of parents with hearing impairment in an attempt to find out how they take care of their children.
Methodology: Five hearing impaired parents are involved as an informant of the study. The method used is an instrumental case study with depth interview as a data collection technique and content analysis as a method of data analysis. The theoretical perspective used is four aspects of parenting behavior from Bornstein.
Results: The results showed that among the four aspects of parenting behavior, the participants have little or no difficulties in nurturant caregiving, maternal caregiving, and social caregiving. With their hearing difficulties, they can do it with help from their parents or relatives. However, they experience difficulties in social caregiving, particularly in responding child’s emotional expressions and building communication with them, and in didactic caregiving particularly in handling disruptive behavior.
Implications/Applications: The results of this study imply the need to conduct further research about parenting behavior of hearing-impaired parents, and parenting alliance between hearing impaired parent and their own parent. It also implies the need to conduct parent training that suitable for hearing impaired parents, especially in handling children emotion and disruptive behavior, to help them better care for their children.
LOCAL GOVERNMENT POLICY MODEL OF INDONESIA RATTAN HANDICRAFT CREATIVE INDUSTRY IN TRANGSAN VILLAGE
Authors: Kumalasari Galuh Wahyu 
Published: April 2019

Purpose of Study: Creative industry is one of the economic sectors that important to get attention from the government. Absorption workers in the creative industry are very large considering the main capital in this industry is idea and creativity. An employee who works on large industry, often replaced by mechanical power by efficiency reason. This is different from the creative industry which had to take creativity owned by a human being to maintain its existence. The rattan industry in this area has been able to penetrate the export market in the Netherlands, Germany, The United States, and Australia. Although has penetrated the export market, a number of problems experienced by actors of the creative industry, such as difficulty in competition with other countries related to the design of products and the difficulties to participate in the event of the international exhibition.
Methodology: The methodology used in this research is nondoctrinal, its describe clearly on local government policy in the development of the rattan creative industry in Trangsan Village, Gatak, Sukoharjo, Central Java.
Results: This study found that one of an industry that relatively has been shown to be able to survive in the center of turbulence and national and global economic crisis is the rattan industry in Trangsan Village.
Implications/Applications: Looking at these problems, the local government should take an active role to provide support for rattan industries of Trangsan Village by facilitating ease licensing and integrated technical assistance in connection to promoting both through social media and facilitation to be fit for as well as in international events.
PUNISHMENT FOR THE EXTRAORDINARY CRIME PERPETRATOR ON CHILDREN ECONOMIC EXPLOITATION IN INDONESIA COMPARISON OF LAW IN AUSTRALIA, SENEGAL AND ENGLAND
Authors: Pamuncak Aristya Windiana 
Published: April 2019

Purpose of Study: Child exploitation and slavery have become a new phenomenon of global crime because it occurred in every part of the world. The exploitation of infants and children in our public perception is underestimated because of cases subject to prosecution only mild and included unusual punishment.
Methodology: This research was normative, in analyzing phenomena that occur in society, the authors attempted to answer some of the problems of the rule of positive law in Indonesia in solving the problems of exploitation of children, how to tackle the exploitation of children by other countries, and recommendations to resolve the problems of exploitation against children.
Results: Exploitation crimes against children or slavery more appropriately included as an extraordinary crime committed against children, because such measures will not only affect the physical and psychological health but also will greatly affect the future of children and the future of a nation.
Implications/Applications: Comparative law between the State of Australia, Senegal, and England, can be recommended for the legislature to make the formulation of regulations on the handling of the exploitation of children more effectively and quickly.