bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implication of ABO Blood Type on Ovarian Reserve in Indian Women
Authors: Chandana C , Shankarappa C 
Published: July 2019

ABSTRACTBackgroundTo explore the association between ABO blood type and ovarian reserve, as reflected by early follicular phase follicle stimulating hormone (FSH) levels.Materials and methodsIn this cross-sectional observational study, early follicular phase (day 3) serum levels of FSH (IU/L) and information on blood types (O, A, B, AB), patient age, and body mass index (BMI) were collected from 300 female patients, who were undergoing fertility evaluation at Vydehi Institute of Medical Sciences and Research Centre (VIMS & RC), Bengaluru. Serum FSH > 10 IU/L was taken as a measure of decreased ovarian reserve (DOR). Data distribution for FSH, age, BMI were analyzed and nonparametric tests were used for comparison across blood groups. Pearson's correlation test was used to determine the relationship between elevated FSH and blood types after adjusting for age and BMI.ResultsProportions of blood types O, A, B, and AB were 42, 24.3, 28.7, and 5% respectively. Mean age (years) and BMI (kg/m2) among study group were 34.08 ± 3.48 and 24.34 ± 2.56 respectively. Out of 300 women, 240 women had serum FSH < 10 IU/L and 60 women had serum FSH > 10 IU/L. Women with blood type “O” (32 out of 60) were twice as likely to exhibit FSH > 10 IU/L (p = 0.02) compared to “A” and “B” blood type.ConclusionOur results have shown that there is an association between ABO blood type and DOR among Indian women. Blood group “O” appears to be associated with DOR that is independent of advancing age and BMI.How to cite this articleChandana C, Shankarappa C. Implication of ABO Blood Type on Ovarian Reserve in Indian Women. Int J Infertil Fetal Med 2016;7(2):49-51.
Uterus Transplantation: An Update and Preparations for Introduction in India
Authors: Dahm-Kähler P , Brännström Mats 
Published: July 2019

ABSTRACTThe clinical field of composite tissue transplantation now also includes uterus transplantation (UTx), a new type of quality-oflife enhancing and in this case also life-giving transplantation. The purpose of UTx is to enable live birth from a woman who lacks uterus or in a woman who has a defective uterus.How to cite this articleRao KA, Dahm-Kähler P, Brännström M. Uterus Transplantation: An Update and Preparations for Introduction in India. Int J Infertil Fetal Med 2016;7(2):61-67.
Endodontic Management of a Mandibular Canine with Two Roots using Cone Beam Computed Tomography as a Diagnostic Aid
Authors: Ahmed Hina , Singh Mahendra P , Singh Gautam 
Published: July 2019

ABSTRACT
Knowledge of anatomic variations is essential for endodontic success, which is related to a thorough debridement of the root canal system. About 2% of mandibular canines presented with one root and two canals, and of that, 1% had two roots and two canals. This case report presents a rare case of a mandibular canine with two roots and its endodontic management. The missed second root of mandibular canine was identified by cone beam computed tomography and was subjected to sound endodontic therapy and restored to proper function and esthetics.

How to cite this article
Ahmed H, Singh MP, Singh G. Endodontic Management of a Mandibular Canine with Two Roots using Cone Beam Computed Tomography as a Diagnostic Aid. Int J Prosthodont Restor Dent 2016;6(4):102-105.
Surgical Management of Severe Case of Laryngomalacia
Authors: Mahore Devendra Meghraj , Kadam Sudhir , Rane Sachin Vasant , Paikrao Yogesh 
Published: July 2019

ABSTRACT
Incidence of congenital laryngeal anomalies is between 1:10,000 and 1:50,000 births. Laryngomalacia is the most common cause of congenital stridor, characterized by partial or complete collapse of the supraglottic structures during inspiration. Patient was having inspiratory stridor at birth or immediately after birth. No active intervention is required in 90% of cases. So we are reporting this rare case that required active intervention and will also show how we managed it.

How to cite this article
Mahore D, Kadam S, Rane SV, Paikrao Y. Surgical Management of Severe Case of Laryngomalacia. Int J Phonosurg Laryngol 2016;6(1):47-48.
Establishing the Cephalometric Values for Tetragon Analysis in Patients with Class I Occlusion: A Cephalometric Study
Authors: Gupta Nishant , Gupta Gunjan , Umasankar K , Sundari KK Shantha 
Published: July 2019

ABSTRACT

Objectives
Proper application of the cephalometric norms for tetragon analysis for better understanding, diagnosis, and management of dentofacial deformities in the ethnic population.

Materials and methods
A total of 204 subjects, inclusive of males (102) and females (102), were selected randomly from the outpatient department of Saveetha Dental College and Hospitals, in the age group ranging from 18 to 25 years, fulfilling the inclusion criteria.
Assessment of each lateral cephalogram was done using tetragon analysis to evaluate the cephalometric values for individuals with class I occlusion using the FACAD® 3.4.0.3 A software.

Results
Statistically significant differences were found for all parameters between the ethnic population and the Caucasian norms. Four out of 14 parameters were found to be significantly different between male and female in the ethnic population.

Conclusion
This study indicates that the local ethnic population have more prognathic maxillary and mandibular jaws, converging tendency of the jaw bases (resulting in reduced lower anterior facial height and horizontal growth pattern) as indicated by the analysis done in the tetragon and the trigon, and increased proclination of the upper and lower incisors.

How to cite this article
Gupta N, Gupta G, Umasankar K, Sundari KKS. Establishing the Cephalometric Values for Tetragon Analysis in Patients with Class I Occlusion: A Cephalometric Study. J Contemp Dent Pract 2016;17(7):597-600.
Post-LASIK Keratoectasia Developing with Sleep Apnea and Floppy Eyelid Syndrome: Case Report and Review of the Literature
Authors: Avni-Zauberman Noa , Rootman David S 
Published: July 2019

ABSTRACT
We report a case of unilateral keratoectasia in a patient who underwent uneventful hyperopic LASIK 8 years prior and was diagnosed with obstructive sleep apnea syndrome (OSAS) and Floppy eyelid syndrome. The before and after LASIK topographies demonstrated clear development of the ectasia after the patient developed OSAS. The patient was treated with collagen cross- linking in the involved eye to stop ectatic progression. Our report emphasizes the importance of inquiring about the patient's sleeping postures and habits (specifically asking about OSAS) and a careful examination of eyelid laxity prior to refractive laser treatment.

How to cite this article
Zauberman NA, Rootman DS. Post- LASIK Keratoectasia Developing with Sleep Apnea and Floppy Eyelid Syndrome: Case Report and Review of the Literature. Int J Kerat Ect Cor Dis 2014;3(1):44-46.
Collagen Cross-linking for the Treatment of Keratoconus in Pediatric Patients
Authors: Castillo Jamyl Habib , Tiosano Beatrice , Hanna Rana , Berkwitz Eran 
Published: July 2019

ABSTRACT
Keratoconus (KC) is a bilateral noninflammatory, ectatic corneal disorder. It is the most common primary ectasia affecting approximately 1 in 2,000 in the general population. Classically, the disease starts in puberty and progresses throughout the 3rd or 4th decades of life. Ocular signs and symptoms vary depending on disease severity. As the disease progresses, approximately 20% of KC eyes require penetrating keratoplasty. Collagen cross-linking (CXL) with ultraviolet-A (UVA) light and riboflavin is a new treatment that has emerged in the recent years. It is reported to slow the progression of the disease in its early stages, by increasing corneal rigidity and biomechanical stability. As the number of adult KC patients treated using this procedure grew, proving its safety and high efficacy, the pediatric KC patients population has started to receive special attention. In the pediatric KC patients’ eyes, corneas have been shown to be significantly steeper at the time of diagnosis compared to adults, and the severity of KC seems inversely correlated with age. Since treating KC in earlier age may be beneficiary, before developing an advanced disease that may require corneal transplantation, CXL in the pediatric age group has been advocated by many practitioners. The aim of this review is to collect and consolidate all known data regarding the efficacy and safety of CXL in the pediatric population.

How to cite this article
Hanna R, Berkwitz E, Castillo JH, Tiosano B. Collagen Cross-linking for the Treatment of Keratoconus in Pediatric Patients. Int J Kerat Ect Cor Dis 2015;4(3):94-99.
Abnormal Regulation of Extracellular Matrix and Adhesion Molecules in Corneas of Patients with Keratoconus
Authors: Bykhovskaya Yelena , Gromova Anastasia , Makarenkova Helen P , Rabinowitz Yaron S 
Published: July 2019

ABSTRACT

Aim
To identify changes in the expression of genes coding for extracellular matrix (ECM) proteins in patients with noninflammatory corneal disorder keratoconus (KC), patients with corneal scarring, and normal controls.

Materials and methods
Total ribonucleic acid extracted from corneal tissue of 13 KC patients, 2 patients with corneal scaring, and 4 normal controls was analyzed using Human Extracellular Matrix & Adhesion Molecules Profiler Polymerase Chain Reaction Array. Statistically significant changes in gene expression were identified using the Data Analysis software.

Results
Comparison of KC and control corneas with thresholds of 1.5 or greater fold change and a p-value of 0.05 or lower revealed 21 differentially expressed genes: 16 genes were downregulated and 5 were upregulated. Among transcripts downregulated in KC patients, we identified thrombospondin 1, disintegrin and metalloproteinase with thrombospondin motif 1, secreted phosphoprotein 1, several collagens, and integrins. We found transforming growth factor beta-induced (TGFBI or BIGH3) gene was the most significantly upregulated transcript.

Conclusion
The development of KC results in deregulation of gene expression of ECM and adhesion molecules.

Clinical significance
Downregulation of collagens and upregulation of TGFBI repeatedly identified in KC patients may be used as clinical markers of the disease.

How to cite this article
Bykhovskaya Y, Gromova A, Makarenkova HP, Rabinowitz YS. Abnormal Regulation of Extracellular Matrix and Adhesion Molecules in Corneas of Patients with Keratoconus. Int J Kerat Ect Cor Dis 2016;5(2):63-70.
Simultaneous Topography-guided Surface Ablation with Collagen Cross-linking for Keratoconus
Authors: Kaiserman Igor , Karmona Lily , Sela Tzahi , Franco Oz , Shoshani Avi , Munzer Gur 
Published: July 2019

ABSTRACT

Purpose
In this article, we present the results of eight eyes of patients who underwent combined same-day partial topography-guided surface ablation followed by accelerated collagen cross-linking (CXL) procedure at Care-Vision Laser Centers to achieve stabilization of corneal ectasia and enhance visual rehabilitation in keratoconus.

Materials and methods
A retrospective nonrandomized review of 8 eyes of 6 patients who underwent the Athens Protocol for progressive keratoconus. Each patient underwent topography-guided ablation followed by CXL procedure.

Follow-up
Follow-up was done on day 1, day 7, and then at 1, 3, 6, and 12 months.

Results
There was a rapid and significant improvement in uncorrected visual acuity and best-corrected visual acuity in 100% eyes, a reduction of keratometric values, and symmetry between vertical hemimeridians. Topographic evaluation showed a marked improvement in irregularity. There were no signs of keratoconic progression noted in any of the eyes on last follow-up. No adverse events were reported in any patient.

Conclusion
Simultaneous surface ablation + CXL seems to be a promising treatment capable of offering patients functional vision and halting progression of the disorder.

Precis
Simultaneous topography-guided custom ablation treatment and photorefractive keratectomy with CXL offers keratoconic patients intolerant to contact lenses both stabilization of the cornea and improved functional vision with spectacles correction.

How to cite this article
Karmona L, Sela T, Franco O, Shoshani A, Munzer G, Kaiserman I. Simultaneous Topography-guided Surface Ablation with Collagen Cross-linking for Keratoconus. Int J Kerat Ect Cor Dis 2016;5(2):71-76.
Bilateral Antrochoanal Polyps: An Analysis from Four Cases
Authors: Gupta Ashok , Jain Prachi , Virk Ramandeep S , Penubarthi Lokesh K , Kaushik Eshaan 
Published: July 2019

ABSTRACT
Bilateral antrochoanal polyps (ACPs) are a rare entity. We studied four cases of bilateral ACPs that presented to us. We found a close association of allergy (75%) and chronic rhinosinusitis (CRS) (50%) as etiological factors. The anatomical factors like deviated nasal septum (75%), inferior turbinate hypertrophy (50%), and concha bullosa (25%) are also commonly associated with bilateral ACPs. Endoscopic sinus surgery was performed in all the patients with special emphasis to correct the anatomical factors. Inferior meatal antrostomy was performed in two cases to allow easy access of the angled microdebrider blade for clearing the polyp from the anterolateral and anterosuperior limits of the antrum. After a mean follow-up period of 23 months, no recurrence was found.

How to cite this article
Virk RS, Penubarthi LK, Gupta AK, Jain P, Kaushik E. Bilateral Antrochoanal Polyps: An Analysis from Four Cases. J Postgrad Med Edu Res 2016;50(4):173-175.
Immunophenotyping in Chronic Myeloid Leukemia Blast Crisis: Looking beyond Morphology
Authors: Varma Subhash , Varma Neelam , Malhotra Pankaj , Narang Vikram , Sachdeva Man US , Bose Parveen 
Published: July 2019

ABSTRACT

Introduction
Patients of chronic myeloid leukemia (CML) eventually transform to blast crisis (BC) after a variable length of chronic phase (CP). With improvement in management protocols, many patients of CML-BC are expected to show remission after initial chemotherapy and a better survival. Hence, it becomes imperative to correctly classify the nature of BC for further course of management.

Materials and methods
This study retrospectively analyzed cases of CML-BC, over a period of 5 years, with comprehensive immunophenotyping done on flow cytometry.

Results
Fifteen cases of CML-BC with male-to-female ratio of 3:1 and mean age of 40.2 years were included in the study. Flow cytometry revealed 14 cases of myeloid and one case of lymphoid BC. One case each of megakaryocytic and myelomonocytic lineage were seen among the 14 cases of myeloid BC. Aberrant marker expression was a common occurrence. Myeloperoxidase cytochemical stain had shown positivity only in 3 of the 14 cases of myeloid BC.

Conclusion
Immunophenotyping is necessary for assigning specific lineage to blasts in patients of CML-BC and thus providing clinically useful information regarding the treatment protocols and prognosis of the patient.

How to cite this article
Narang V, Sachdeva MUS, Bose P,
Varma N, Malhotra P, Varma S. Immunophenotyping in Chronic Myeloid Leukemia Blast Crisis: Looking beyond Morphology. J Postgrad Med Edu Res 2016;50(4):181-184
“The TMJ Sound Scout”: Device to diagnose Temporomandibular Joint Sound
Authors: Sethuraman Rajesh , Prajapati Paranjay , Rao Naman , Patel Jayanti R 
Published: July 2019

ABSTRACTAimsTraining and teaching the students about the temporomandibular disorders (TMDs) and related sounds which can be used for its diagnosis is difficult for both teacher and students in terms of explanation and understanding. It is difficult for operator to explain about the condition of temporomandibular joint (TMJ) sounds in disease state and same way it is difficult to understand as patients.There is a need for a simple and handy device that can be used for teaching purpose in classrooms and institutional dental clinics and also for patients’ education and diagnosis.This paper presents a meek, easy to assemble, and economic electronic device to diagnose and record TMJ sounds.Temporomandibular joint (TMJ) disorders are very common in the current era due to stressful lifestyle and working environment. Some of them remain unnoticed and undiagnosed due to lack of patient motivation, education, and also due to lack of operators’ knowledge and skill to diagnose the same.Students’ training and education also need reform and advancement in the field of TMDs. The paper explains about manufacturing of simple and handy device to diagnose and record TMJ sounds. The instrument can be used for teaching and training of students in teaching institutes and clinics. It can also be used for patient education purpose.How to cite this articlePrajapati P, Rao N, Sethuraman R, Patel JR. “The TMJ Sound Scout”: Device to diagnose Temporomandibular Joint Sound. J Contemp Dent 2016;6(2):114-116.
Prevalence of Deep Dental Caries and Its Association with Levels of Water Fluoridation, Age, Gender, and Oral Hygiene Status in the Semiurban Areas of Navi Mumbai
Authors: Padhye Ashvini M , Patil Karishma R , Parab Pooja R , Patil Nandana R 
Published: July 2019

ABSTRACTAimThis survey-based study intends to explore a potential association between the prevalence of deep dental caries and variables, such as age, gender, oral hygiene status, and levels of water fluoridation in the areas of residence of the subjects.Materials and MethodsA systematic oral examination was carried out using a questionnaire and clinical examination for a sample of 487 subjects reporting to the outpatient department at MGM Dental College and Hospital. Data regarding deep dental caries, age, gender, oral hygiene status were collected in this manner. The levels of water fluoridation were determined by data collected from government water testing laboratories. Data collected were analyzed using central tendency of fluoride levels, Pearson's correlation, chi-square test, and the slice and dice technique for a confidence limit of 95%.ResultsA statistically significant association exists between fluoride levels in drinking water and deep dental caries. No significant association was found between age, gender, oral hygiene status, and deep dental caries.ConclusionWithin the limitations of this study, the results suggest that low water fluoridation levels affect the prevalence of deep dental caries.Clinical significanceThis study stresses on the importance of water fluoridation in semi-urban areas for the prevention of dental caries and aids in the outlook toward better awareness.How to cite this articlePatil KR, Parab PR, Padhye AM, Ram SM, Patil NR. Prevalence of Deep Dental Caries and Its Association with Levels of Water Fluoridation, Age, Gender, and Oral Hygiene Status in the Semiurban Areas of Navi Mumbai. J Contemp Dent 2016;6(2):137-141.
Effect of Bi-jaw Premolar Extractions on Tooth Size Discrepancy in an Indian Population having Class I Malocclusion: An in vitro Study
Authors: Sonawane Manish , Krishnan Ravindranath V , Karandikar Girish R , Tahilramani Samay 
Published: July 2019

ABSTRACTAimTo evaluate the effect of bi-jaw premolar extractions on Bolton tooth size discrepancy in patients of Indian origin, all of which exhibited a bilateral Angle’s class I molar relationship.Materials and methodsNinety sets of pretreatment study casts, which constituted the sample for the study, were divided into three groups, namely, Bolton small (BS), Bolton normal (BN), and Bolton big (BB). Simulated bi-jaw extraction of premolars was carried out in four different combinations for each set of study cast. The four values of Bolton’s overall ratio (BOR) thus obtained were compared with the original BOR value.ResultsThe BOR value reduced when subjected to any of the four combinations of bi-jaw premolar extractions.ConclusionPremolar extraction in any combination inevitably changes the BOR value, which potentially affects the settling of occlusion toward the finishing stages of orthodontic treatment.Clinical significanceThe present study provides an insight into the choice of bi-jaw premolar extraction combination for each of the three groups in patients exhibiting class I malocclusion in the Indian population.How to cite this articleTahilramani S, Karandikar GR, Krishnan RV, Sonawane M. Effect of Bi-jaw Premolar Extractions on Tooth Size Discrepancy in an Indian Population having Class I Malocclusion: Anin vitroStudy. J Contemp Dent 2017;7(2):114-117.
Clinical Application of Modified Apically Repositioned Flap in Class III/IV Gingival Recession Cases
Authors: Kosala Manab , Mandlik Vivek Bapurao , Singh Harjeet 
Published: July 2019

ABSTRACTAimMucogingival conditions may be detected during a comprehensive or problem-focused periodontal examination. The aim of periodontal therapy is to help maintain the dentition or its replacements in health with good function and esthetics, and may include restoring anatomic form and function. A further goal is to reduce the risk of progressive recession. Among the procedures, root coverage has attracted the most interest. A predictable gain can be achieved in class I or II recession cases, but prognosis tends to be poor for class III and IV. The purpose of this case series was to clinically evaluate the efficacy of modified apically repositioned flap in increasing the dimensions of the keratinized tissue in apical direction in class III or IV gingival recession.Materials and methodsA total of seven systemically healthy patients with class III or IV recession involving one or more teeth in mandibular anterior region were selected for the study. Primary parameters assessed were width of keratinized gingiva and pocket depth.ResultsThe mean apicocoronal gain in the keratinized tissue at 6 months was 2.14 mm with mean baseline value of 1.43 mm and 6 months value at 3.57 mm. The clinical gain was statistically significant with p-value <0.05.ConclusionModified apically displaced flap offers an easy and predictable approach for increasing the width of keratinized tissue.How to cite this articleSingh H, Kosala M, Mandlik VB. Clinical Application of Modified Apically Repositioned Flap in Class III/IV Gingival Recession Cases. J Contemp Dent 2017;7(2):130-134.
Management and Outcome of Ectopic Pregnancy in a Tertiary Care Center
Authors: Prasad Nagendra , Alpana T 
Published: July 2019

ABSTRACT

Objective
To assess the results of management of ectopic pregnancy with respect to maternal morbidity and mortality and to analyze the risk factors.

Materials and methods
Hospital based cross-sectional study of 52 patients who were diagnosed as ectopic pregnancy in the reproductive age group of 15 to 44 years.

Results
A total of 62 patients with ectopic pregnancy were identified and studied. The rate of ectopic pregnancy was 1.26:100 deliveries. The mean age was found to be 26 years and majority of them were multigravida (Tables 1 and 2). The most common presenting symptom was abdominal pain (96.15%) (Table 3). Most patients had tubal ectopic pregnancy (94.2%). Ovarian ectopic occurred in two cases and 1 patient had heterotopic pregnancy. Emergency laparotomy was performed in 39 (62.90%) patients, 3 (5.77%) patients received methotrexate injection while 18 (29.0%) patients were managed by operative laparoscopy (Table 5). All cases of laparotomy did not require any further procedure. Out of three cases, 2 (66.66%) cases of medical treatment were successful while only 1 (33.33%) case proceeded to emergency laparotomy. No maternal death occurred. Intensive care unit (ICU) stay was needed in 5 patients. Risk factors were found in 67.3% and most common risk factor was found to be previous pelvic surgeries (56.45%) (Table 6). Heterotopic pregnancy was managed by expectant method. Two patients were of post-intrauterine contraceptive device.

Conclusion
Although there was no mortality in our study, morbidity was significant which required multiple blood transfusion and ICU admission. High degree of suspicion, early diagnosis using hormonal studies, sonography, and management in an institutional set up can reduce the associated morbidity.

How to cite this article
Alpana T, Nagarathnamma R, Prasad N. Management and Outcome of Ectopic Pregnancy in a Tertiary Care Center. J Med Sci 2016;2(3):45-47.