bluuebunny/crossref_metadata_2025_split huggingface dataset:
Super‐quenched Molecular Probe Based on Aggregation‐Induced Emission and Photoinduced Electron Transfer Mechanisms for Formaldehyde Detection in Human Serum
Authors: Yang Haitao , Wang Fujia , Zheng Jilin , Lin Hao , Liu Bin , Tang Yi‐Da , Zhang Chong‐Jing 
Published: April 2018

AbstractEnergy transfer between fluorescent dyes and quenchers is widely used in the design of light‐up probes. Although dual quenchers are more effective in offering lower background signals and higher turn‐on ratios than one quencher, such probes are less explored in practice as they require both quenchers to be within the proximity of the fluorescent core. In this contribution, we utilized intramolecular motion and photoinduced electron transfer (PET) as quenching mechanisms to build super‐quenched light‐up probes based on fluorogens with aggregation‐induced emission. The optimized light‐up probe possesses negligible background and is able to detect not only free formaldehyde (FA) but also polymeric FA, with an unprecedented turn‐on ratio of >4900. We envision that this novel dual quenching strategy will help to develop various light‐up probes for analyte sensing.
Synchronization and Tracking of Multi‐Spacecraft Formation Attitude Control Using Adaptive Sliding Mode
Authors: Zhang Chengxi , Wang Jihe , Zhang Dexin , Shao Xiaowei 
Published: April 2018

AbstractThis paper presents the finite‐time attitude synchronization and tracking control method of undirected multi‐spacecraft formation with external disturbances. First, a modified adaptive nonsingular fast terminal sliding mode surface (ANFTSMS) is designed by introducing a user‐defined function, both of which avoid the singularity problem and continuous sliding surface, and, therefore, can freely adjust relative weighting between angular velocity error and attitude error adaptively, such that the controller can provide sufficient maneuvers and precision. This provides designers with a new technique to adjust and improve formation control performance. Second, by applying the ANFTSMS associated with adaptation, two proposed decentralized ANFTSM‐controllers provide finite‐time convergence, robustness to disturbance, and chattering free for continuous design. Finally, simulation results validate the proposed algorithms.
A sensitive LC–MS/MS‐based bioanalytical method for quantification of salviaflaside and rosmarinic acid in rat plasma and its application in a pharmacokinetic study
Authors: Yang Yimin , Ying Sha , Li Te , Zhen Juan , Chen Dongmei , Wang Jianmeng 
Published: April 2018

AbstractA selective and sensitive liquid chromatography tandem mass spectrometry method was developed for the simultaneous determination of salviaflaside and rosmarinic acid in rat plasma. Sample preparation was carried out through liquid–liquid extraction with ethyl acetate using curculigoside as internal standard (IS). The analytes were determined by selected reaction monitoring operated in the positive ESI mode. Chromatographic separation was performed on an Agilent Eclipse Plus C18 column (100 × 4.6 mm, 1.8 μm) with a mobile phase consisting of methanol–water–formic acid (50:50:0.1, v/v/v) at a flow rate of 0.3 mL/min. The run time was 1.9 min per sample and the injection volume was 5 μL. The method had an LLOQ of 1.6 ng/mL for salviaflaside and 0.94 ng/mL for rosmarinic acid in plasma. The linear calibration curves were fitted over the range of 1.6–320 ng/mL for salviaflaside and 0.94–188 ng/mL for rosmarinic acid in plasma with correlation coefficients (r2) >0.99. Intra‐ and inter‐day precisions (relative standard deviation) were < 13.5%, and accuracies (relative error) were between −8.6% and 14.5% for all quality control samples. The method was validated and applied to the pharmacokinetics of salviaflaside and rosmarinic acid in plasma after oral administration of Prunella vulgaris extract to rats.
The asymmetry of neural symptoms in Wilson's disease patients detecting by diffusion tensor imaging, resting‐state functional MRI, and susceptibility‐weighted imaging
Authors: Zhou Xiang‐xue , Li Xun‐hua , Chen Ding‐bang , Wu Chao , Feng Li , Chu Jian‐ping , Yang Zhi‐yun , Li Xin‐bei , Qin Haolin , Li Gui‐dian , Huang Hai‐wei , Liang Ying‐ying , Liang Xiu‐ling 
Published: April 2018

AbstractObjectiveTo investigate the cause of the motor asymmetry in Wilson's disease (WD) patients using functional MRI.MethodsFifty patients with WD and 20 age‐matched healthy controls were enrolled. Neurological symptoms were scored using the modified Young Scale. All study subjects underwent diffusion tensor imaging (DTI), susceptibility‐weighted imaging (SWI), and resting‐state functional MRI (rs‐fMRI) of the brain. Six regions of interest (ROI) were chosen. Fiber volumes between ROIs on DTI, corrected phase (CP) values on SWI, amplitude of low‐frequency fluctuation (ALFF), and regional homogeneity (REHO) values on rs‐fMRI were determined. Asymmetry index (right or left value/left or right value) was evaluated.ResultsAsymmetry of rigidity, tremor, choreic movement, and gait abnormality (asymmetry index = 1.33, 1.39, 1.36, 1.40), fiber tracts between the GP and substantia nigra (SN), GP and PU, SN and thalamus (TH), SN and cerebellum, head of the caudate nucleus (CA) and SN, PU and CA, CA and TH, TH and cerebellum (asymmetry index = 1.233, 1.260, 1.269, 1.437, 1.503, 1.138, 1.145, 1.279), CP values in the TH, SN (asymmetry index = 1.327, 1.166), ALFF values, and REHO values of the TH (asymmetry index = 1.192, 1.233) were found. Positive correlation between asymmetry index of rigidity and fiber volumes between the GP and SN, SN and TH (r = .221, .133, p = .043, .036), and tremor and fiber volumes between the CA and TH (r = .045, p = .040) was found.ConclusionsThe neurological symptoms of patients with WD were asymmetry. The asymmetry of fiber projections may be the main cause of motor asymmetry in patients with WD.
Assessment of sleep quality using cardiopulmonary coupling analysis in patients with Parkinson's disease
Authors: Chen Lindi , Liu Chunyan , Ye Zhinan , Wang Binda , He Songbin 
Published: April 2018

AbstractObjectivesTo assess the sleep quality of patients with Parkinson's disease (PD) and evaluate the effect of cardiopulmonary coupling (CPC) analysis on sleep quality and its correlation with subjective complaints in patients with PD.MethodsOur study included 42 patients with PD and 30 healthy controls. CPC analysis and the Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the sleep quality of subjects.ResultsHigh‐frequency coupling (HFC) and sleep efficiency were significantly lower in the PD than in the control group, whereas very low‐frequency coupling (VLFC) and sleep latency were significantly higher in the PD than in the control group. PSQI scores were significantly higher in the PD than in the control group (all p < .05). The PSQI score showed a negative correlation with the HFC ratio in the PD group (r = −.478, p = .001). Factors related to the occurrence of PD with poor sleep quality were the unified Parkinson's disease rating scale (UPDRS) score and nocturia.ConclusionsThe sleep quality of patients with PD was generally decreased. CPC analysis can reflect the subjective sleep quality of patients with PD and serve as an effective sleep monitoring tool.
Risk factors for breast cancer in a cohort of mammographic screening program: a nested case–control study within the FRiCaM study
Authors: Bravi Francesca , Decarli Adriano , Russo Antonio Giampiero 
Published: April 2018

AbstractBreast cancer is the most common cancer diagnosis and the leading cause of cancer death among women in the world, and differences across populations indicate a role of hormonal, reproductive and lifestyle factors. This study is based on a cohort of 78,050 women invited to undergo a mammogram by Local Health Authority of Milan, between 2003 and 2007. We carried out a nested case–control study including all the 3303 incident breast cancer cases diagnosed up to 2015, and 9909 controls matched by age and year of enrollment. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using logistic regression models. The ORs were 0.88 (95% CI: 0.78–0.98) for an age at menarche ≥14 years and 1.39 (95% CI: 1.07–1.81) for an age of 30 years or older at first pregnancy. Body mass index (BMI) was positively associated with breast cancer risk in women older than 50 years (OR = 1.89, 95% CI: 1.54–2.31, for BMI≥30 vs. <20), while the association tended to be inverse in younger women. A high mammographic density increased breast cancer risk (OR = 2.61, 95% CI: 2.02–3.38 for density >75% vs. adipose tissue). The ORs were 1.67 (95% CI: 1.47–1.89) and 2.04 (95% CI: 1.38–3.00) for one first‐degree relative and two or more relatives affected by breast cancer, respectively. Our study confirms the role of major recognized risk factors for breast cancer in our population and provides the basis for a stratification of the participants in the mammographic screening according to different levels of risk.
Incidence and survival of hematological cancers among adults ages ≥75 years
Authors: Krok‐Schoen Jessica L. , Fisher James L. , Stephens Julie A. , Mims Alice , Ayyappan Sabarish , Woyach Jennifer A. , Rosko Ashley E. 
Published: April 2018

AbstractEvaluating population‐based data of hematologic malignancies (HMs) in older adults provides prognostic information for this growing demographic. Incidence rates and one‐ and five‐year relative survival rates were examined for specific HMs among adults ages ≥75 years using data from the Surveillance, Epidemiology and End Results (SEER) Program. Hematologic malignancy cases (Hodgkin lymphoma (HL), non‐Hodgkin lymphoma (NHL), multiple myeloma (MM), acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML)) were reported to one of 18 SEER registries. Recent average annual (2010–2014) incidence rates and incidence trends from 1973 to 2014 were examined for cases ages ≥75 years. One‐ and five‐year relative cancer survival rates were examined for adults ages ≥75 years diagnosed 2007–2013, with follow‐up into 2014. From 1973 to 2014, incidence rates increased for NHL, MM, and AML, decreased for HL, and remained relatively stable for ALL, CLL, and CML among adults ages ≥75 years. The highest one‐ and five‐year relative survival rates were observed among adults with CLL ages 75–84 years (1 year: 91.8% (95% CI = 91.8–90.8)) and 5 years: 76.5% (95% CI = 74.2–78.6)). The lowest one‐ and five‐year survival rates were observed among adults with AML ages 75–84 (1 year: 18.2% (95% CI = 74.2–78.6) and 5 years: 2.7% (95% CI = 2.0–3.6)). Survival for older adults ages ≥75 years with HMs is poor, particularly for acute leukemia. Understanding the heterogeneity in HM outcomes among older patients may help clinicians better address the hematological cancer burden and mortality in the aging population.
Overexpression of ZAKβ in human osteosarcoma cells enhances ZAKα expression, resulting in a synergistic apoptotic effect
Authors: Fu Chien‐Yao , Tseng Yan‐Shen , Chen Ming‐Cheng , Hsu Hsi‐Hsien , Yang Jaw‐Ji , Tu Chuan‐Chou , Lin Yueh‐Min , Viswanadha Vijaya Padma , Ding Ke , Kuo Wei‐Wen , Huang Chih‐Yang 
Published: April 2018

ZAK is a novel mixed lineage kinase‐like protein that contains a leucine‐zipper and a sterile‐alpha motif as a protein‐protein interaction domain, and it is located in the cytoplasm. There are 2 alternatively spliced forms of ZAK: ZAKα and ZAKβ. Previous studies showed that ZAKα is involved in various cell processes, including cell proliferation, cell differentiation, and cardiac hypertrophy, but the molecular mechanism of ZAKβ is not yet known. In a recent study in our laboratory, we found that ZAKβ can ameliorate the apoptotic effect induced by ZAKα in H9c2 cells. We further hypothesized that ZAKβ could also improve the apoptotic effect induced by ZAKα in human osteosarcoma cells. The results of this study show that ZAKβ can induce apoptosis and decrease cell viability similar to the effects of ZAKα. Interestingly, our ZAKα‐specific inhibitor assay shows that the expression of ZAKβ is highly dependent on ZAKα expression. However, ZAKβ expression effectively induces ZAKα expression and results in synergistic enhancement of apoptosis in human osteosarcoma cells. Furthermore, co‐immunoprecipitation results revealed that ZAKα can directly interact with ZAKβ, and this interaction may contribute to the enhanced apoptotic effects.Significance of the studyZAK is a mixed lineage kinase involved in cell differentiation, proliferation, and hypertrophic growth. ZAKα isoform of ZAK is associated with tumorigenesis, but the function of ZAKβ is not yet known. In H9c2 cells, ZAKβ was found to ameliorate the apoptotic effect induced by ZAKα. However, in osteosarcoma cells, ZAKβ elevates the apoptotic effect induced by ZAKα. In this study, we show that similar to ZAKα, the ZAKβ induces apoptosis and decreases cell viability. Interestingly, the expression of ZAKβ is dependent on ZAKα expression, and ZAKβ further enhances ZAKα expression and results in synergistic enhancement of apoptosis in osteosarcoma cells.
Pacemaker‐mediated tachycardia with narrow QRS complexes
Authors: Yoo Hyun Sok , Albino Ernesto , Fernandez Pablo , Etcheverry Daniel , Tepper Rita , Garro Hugo , Pastori Julio , Acunzo Rafael 
Published: April 2018

Key Clinical MessageInverted connection of the atrial and ventricular leads is an unusual circumstance during the implantation of a dual‐chamber pacemaker. Yet, PMT may present in the absence of complex mechanisms. The detection and termination algorithms used by the device proved to be efficient for the adequate diagnosis and treatment.
Successful pregnancies after neonatal aortic thrombosis, childhood arterial repair, and a deficient pelvic vasculature
Authors: Troëng Thomas , Bergqvist Agneta , Bergqvist David 
Published: April 2018

Key Clinical MessageNeonatal aortic bifurcation thrombosis can cause occlusion of iliac arteries causing abnormal pelvic vasculature and claudication in childhood. A bifurcation graft normalizes the perfusion of the legs but not of the pelvis. In a girl, this does not preclude successful pregnancies in adult life. It has not been reported before.
No risk reduction for Plasmodium vivax malaria in sickle cell disease
Authors: Moiz Bushra , Majeed Ayesha 
Published: April 2018

Key Clinical MessageHemoglobin S is known to protect against uncomplicated Plasmodium falciparum malaria. However, there is paucity of the literature regarding interaction of HbS and other malaria species. Usually, P. vivax malaria is a relapsing condition, and without radical cure with primaquine, recurrence may be observed even with hemoglobin S.
Acrodermatitis dysmetabolica as a sign of methylmalonic aciduria decompensation
Authors: Rosa Joana , Fraga Ana Beatriz , de Carvalho Rita , Maia Ana Lúcia , Rodrigues Ana Luísa , Gomes Maria Fernanda 
Published: April 2018

Key Clinical MessageMethylmalonic aciduria children must follow an adequate diet with low protein intake and should be regularly monitored to prevent complications. Although skin lesions like acrodermatitis enteropathica are rare in this disease, their appearance should be correlated with possible low plasma isoleucine level and it can be a sign of decompensation.
A novel mutation in the NAGLU gene associated with Sanfilippo syndrome type B (mucopolysaccharidosis III B)
Authors: Hettiarachchi Dineshani , Nethikumara Nilaksha , Pathirana Bamunu Arachchi Pathiranage Sajeewani , Weththasigha Kalum , Dissanayake Weerabaddana Dilshani Niluka , Dissanayake Vajira H. W. 
Published: April 2018

Key Clinical MessageHomozygous or compound heterozygous mutation in the gene encoding N‐alpha‐acetylglucosaminidase (NAGLU) on chromosome 17q21 results in Sanfilippo B, resulting in excess accumulation of intralysosomal glycosaminoglycans (mucopolysaccharides) in various tissues. We wish to report a novel homozygous variant in a child with features of Sanfilippo syndrome B.
A case of extreme weight loss due to mesenteric ischemia and antiphospholipid syndrome
Authors: Melas Nikolaos , Haji Younes Amil , Lindberg Robert , Magnusson Peter 
Published: April 2018

Key Clinical MessageMesenteric ischemia and antiphospholipid syndrome is a rare combination but should be suspected as a differential diagnosis. This may be presented as diffuse abdominal pain typically after food intake, diarrhea, and weight loss. Early recognition is warranted, and nutrition, stenting, and anticoagulant treatments are indicated.
Cor triatriatum dexter
Authors: Zoltowska Dominika , Kalavakunta Jagadeesh K 
Published: April 2018

Key Clinical MessageCor triatriatum dexter (CTD) is an extremely rare finding (<0.01%), resulting from the persistence of the right valve of sinus venosus. Echocardiography with color Doppler is the first‐line tool for diagnosis and decision making.
Photocatalytic Composite of a Floating BiOBr@Graphene Oxide@Melamine Foam for Efficient Removal of Organics
Authors: Liu Wenhua , Gao Yuan , Yang Yuping , Zou Quan , Yang Guoxiang , Zhang Ziping , Li Huifan , Miao Yingchun , Li Hexing , Huo Yuning 
Published: April 2018

AbstractHierarchical photocatalytic composite BiOBr@graphene oxide@melamine foam was developed by using a solvothermal process. In this composite, the graphene oxide‐wrapped melamine foam acted as the substrate for supporting the catalyst, and the BiOBr nanosheets stably combined with the graphene oxide surface in a uniform distribution. This composite could be floated on the solution surface to inhibit the light shielding effect of colorful organic pollutants. Furthermore, the graphene oxide‐wrapped melamine foam provided mass transfer channels for organics and enriched the organics in its 3D structure. BiOBr nanosheets presented efficient photodegradation of organics and solved the problem of adsorption saturation of graphene oxide@melamine foam. Graphene oxide could further improve the light utilization, inhibit the recombination of charges, and enrich the organics. In view of the synergistic effect of adsorption and photocatalysis, this catalyst system realized the efficient removal of the organic rhodamine B and presented the promoted amount of contaminant removal with increased rhodamine B concentration.
One‐step Synthesis of α‐Keto Acids from Racemic Amino Acids by A Versatile Immobilized Multienzyme Cell‐free System
Authors: Orrego Alejandro H. , López‐Gallego Fernando , Espaillat Akbar , Cava Felipe , Guisan José M. , Rocha‐Martin Javier 
Published: April 2018

AbstractThe elevated value of α‐keto acids has pushed scientists to explore more efficient and less expensive alternatives for their synthesis. In this work, an immobilized tri‐enzyme system that produced α‐keto acids in “one‐pot” from l‐ or racemic mixtures of diverse amino acids was presented. The system combined a broad‐spectrum amino acid racemase (BsrV), a d‐amino acid oxidase (DAAO) and catalase (CAT). BsrV racemized l‐amino acids into their d‐enantiomers, DAAO catalyzed the stereospecific oxidative deamination of the d‐amino acids into their corresponding α‐keto acids, ammonium ion, and H2O2. Finally, CAT converted the inactivating H2O2 into H2O and O2, which can be reused by the oxidase reaction. BsrV thermal stability was improved 3,300‐fold by immobilizing the enzyme on glyoxyl‐activated agarose beads. DAAO and CAT were co‐immobilized on agarose beads functionalized with glutaraldehyde groups for enhancing their stabilities and eliminating H2O2 in a much more effective way. To show the versatility of this system, racemic mixtures of amino acids were converted in their corresponding α‐keto acids. The coupling of the three immobilized enzymes permitted conversions of approximately 99 % through a dynamic kinetic resolution process. This system conserved 100 % of its initial effectiveness after 8 reaction cycles. Collectively, our innovative tri‐enzyme system for the synthesis of α‐keto acids opens the door for a cheapening in the production of many pharmaceutical and cosmetics.
Carbodicarbenes and their Captodative Behavior in Catalysis
Authors: Liu Shu‐kai , Shih Wei‐Chih , Chen Wen‐Ching , Ong Tiow‐Gan 
Published: April 2018

AbstractThe front cover artwork for issue 7/2018 is provided by Ong research group at Institute of Chemistry, Academia Sinica (Republic of China). The image shows a new family of ligands, that of carbodicarbenes. Because of their stronger σ‐donating capability, they have a huge potential to become a new class of scaffolds in organometallic chemistry and catalysis. See the Concept itself at https://doi.org/10.1002/cctc.201701577.
Nitrogenated Urchin‐like Nb2O5 Microspheres with Extraordinary Pseudocapacitive Properties for Lithium‐Ion Capacitors
Authors: Chen Zhijie , Li Hongsen , Lu Xiaoxia , Wu Langyuan , Jiang Jiangmin , Jiang Songbai , Wang Junjun , Dou Hui , Zhang Xiaogang 
Published: April 2018

AbstractRecently, lithium‐ion capacitors (LICs) combining the complementary characteristics of both lithium‐ion batteries (LIBs) and supercapacitors, have received exhaustive investigation to meet the increasing demands for clean energy. However, their commercial application has been limited by the mismatch of charge‐storage capacity and electrode kinetics between the capacitor‐type cathode and battery‐type anode. Thus, developing a novel high‐power insertion anode material is the key to realizing excellent energy and power densities for LICs. Here, 3D hierarchical Nb2O5 microspheres assembled by surface‐nitrogenated nanowires have been synthesized through a unique anti‐solvent precipitation‐assisted solvothermal route accompanied by a nitrogenization treatment, which can be successfully used for advanced LICs configuration. Owing to the high aspect ratio of ultrathin nanowires, unique pore structures caused by nitridation, improved electronic conductivity, and favorable kinetic stemming from pseudocapacitive behavior, the resultant nitrogenated Nb2O5 microspheres can deliver a high capacity of 205.3 mAh g−1 with remarkable rate capability and long lifespan. When constructed into a new LIC device with peanut‐shell derived carbon (PSC) cathode, an exceptionally high energy density of ∼83.5 Wh kg−1 and a high power density of 10 kW kg−1 with prominent cycling stability are realized. Significantly, the simultaneous manipulation of superstructure design and surface nitrogenization in novel anode material provides new opportunities to boost the energy and power densities for hybrid‐ion capacitors.
Nitrogen‐Doped Graphdiyne as High‐capacity Electrode Materials for Both Lithium‐ion and Sodium‐ion Capacitors
Authors: Shen Xiangyan , Yang Ze , Wang Kun , Wang Ning , He Jianjiang , Du Huiping , Huang Changshui 
Published: April 2018

AbstractNitrogen‐doped graphdiyne (N‐GDY) is prepared through the nitriding of graphdiyne (GDY) under ammonia. This material possesses excellent ability for the fast diffusion and storage of lithium and sodium ions due to its high conductivity, wide interlayer distance, unique three‐dimensional porous structure, and associated defects from nitrogen doping. The lithium‐ion capacitor (LIC) and sodium‐ion capacitor (SIC) fabricated with N‐GDY as the negative electrode show outstanding electrochemical performance, especially having both high power density and energy density. Besides exhibiting an energy density of 174 Wh kg−1, the N‐GDY‐based LIC can still offer an energy density of 107 Wh kg−1even at a power density of 11250 W kg−1, whereas the N‐GDY‐based SIC can retain an energy density of 119 Wh kg−1at a power density of 22500 W kg−1. The energy densities of N‐GDY‐based LIC and SIC are higher than those of pure GDY and many other carbon materials.