bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facial masculinity is only weakly correlated with handgrip strength in young adult women
Authors: Hahn Amanda C. , Holzleitner Iris J. , Lee Anthony J. , Kandrik Michal , O'Shea Kieran J. , DeBruine Lisa M. , Jones Benedict C. 
Published: November 2018

AbstractObjectivesAncestrally, strength is likely to have played a critical role in determining the ability to obtain and retain resources and the allocation of social status among humans. Responses to facial cues of strength are therefore thought to play an important role in human social interaction. Although many researchers have proposed that sexually dimorphic facial morphology is reliably correlated with physical strength, evidence for this hypothesis is somewhat mixed. Moreover, to date, only one study has investigated the putative relationship between facial masculinity and physical strength in women. Consequently, we tested for correlations between handgrip strength and objective measures of face‐shape masculinity.Methods531 women took part in the study. We measured each participant's handgrip strength (dominant hand). Sexual dimorphism of face shape was objectively measured from each face photograph using two methods: discriminant analysis and vector analysis. These methods use shape components derived from principal component analyses of facial landmarks to measure the probability of the face being classified as male (discriminant analysis method) or to locate the face on a female‐male continuum (vector analysis method).ResultsOur analyses revealed that handgrip strength is, at best, only weakly correlated with facial masculinity in women. There was a weak significant association between handgrip strength and one measure of women's facial masculinity. The relationship between handgrip strength and our other measure of women's facial masculinity was not significant.DiscussionTogether, these results do not support the hypothesis that face‐shape masculinity is an important cue of physical strength, at least in women.
Pressure‐Induced Diels–Alder Reactions in C6H6‐C6F6 Cocrystal towards Graphane Structure
Authors: Wang Yajie , Dong Xiao , Tang Xingyu , Zheng Haiyan , Li Kuo , Lin Xiaohuan , Fang Leiming , Sun Guang'ai , Chen Xiping , Xie Lei , Bull Craig L. , Funnell Nicholas P. , Hattori Takanori , Sano‐Furukawa Asami , Chen Jihua , Hensley Dale K. , Cody George D. , Ren Yang , Lee Hyun Hwi , Mao Ho‐kwang 
Published: November 2018

AbstractPressure‐induced polymerization (PIP) of aromatics is a novel method for constructing sp3‐carbon frameworks, and nanothreads with diamond‐like structures were synthesized by compressing benzene and its derivatives. Here by compressing a benzene‐hexafluorobenzene cocrystal (CHCF), H‐F‐substituted graphane with a layered structure in the PIP product was identified. Based on the crystal structure determined from the in situ neutron diffraction and the intermediate products identified by gas chromatography‐mass spectrum, we found that at 20 GPa CHCF forms tilted columns with benzene and hexafluorobenzene stacked alternatively, and leads to a [4+2] polymer, which then transforms to short‐range ordered H‐F‐substituted graphane. The reaction process involves [4+2] Diels–Alder, retro‐Diels–Alder, and 1‐1′ coupling reactions, and the former is the key reaction in the PIP. These studies confirm the elemental reactions of PIP of CHCF for the first time, and provide insight into the PIP of aromatics.
AIEgens/Nucleic Acid Nanostructures for Bioanalytical Applications
Authors: Wang Xudong , Xu Min , Huang Kaixun , Lou Xiaoding , Xia Fan 
Published: November 2018

AbstractDNA occupies significant roles in life processes, which include encoding the sequences of proteins and accurately transferring genetic information from generation to generation. Recent discoveries have demonstrated that a variety of biological functions are correlated with DNA′s conformational transitions. The non‐B form has attained great attention among the diverse forms of DNA over the past several years. The main reason for this is that a large number of studies have shown that the non‐B form of DNA is associated with gross deletions, inversions, duplications, translocations as well as simple repeating sequences, which therefore causes human diseases. Consequently, the conformational transition of DNA between the B‐form and the non‐B form is important for biology. Conventional fluorescence probes based on the conformational transitions of DNA usually need a fluorophore and a quencher group, which suffers from the complex design of the structure and tedious synthetic procedures. Moreover, conventional fluorescence probes are subject to the aggregation‐caused quenching (ACQ) effect, which limits their application toward imaging and analyte detection. Fluorogens exhibiting aggregation‐induced emission (AIE) have attracted tremendous attention over the past decade. By taking advantage of this unique behavior, plenty of fluorescent switch‐on probes without the incorporation of fluorescent quenchers/fluorophore pairs have been widely developed as biosensors for imaging a variety of analytes. Herein, the recent progress in bioanalytical applications on the basis of aggregation‐induced emission luminogens (AIEgens)/nucleic acid nanostructures are presented and discussed.
Effect of high uric acid on the disposition of metformin: in vivo and in vitro studies
Authors: Zhang Guoqiang , Ma Yanrong , Xi Dali , Rao Zhi , Sun Xiaohan , Wu Xin'an 
Published: November 2018

AbstractMetformin is always used as the baseline antidiabetic therapy for patients with type 2 diabetes mellitus (T2DM) and hyperuricemia. Metformin is excreted into urine through active secretion mediated by rOCTs and rMATE1.The aim of this study was to identify the effects of high uric acid on the disposition and its mechanism. For the in vivo study, a hyperuricemic animal model was induced by intraperitoneal injection of potassium oxonate (250 mg/kg) in rats. Metformin (100 mg/kg) was administered orally to investigate the pharmacokinetics in control and hyperuricemic rats, respectively. For the in vitro study, HEK293 and HepaRG cells were used to investigate the effect of uric acid (15 mg/dl) on the expression of OCT1, OCT2 and MATE1 and the disposition of metformin, respectively. The in vivo study showed that the AUC0 → 600 of metformin was significantly decreased by 33.3%, whereas the cumulative urinary excretion of metformin was increased by 25.4% in hyperuricemic rats compared with that in control rats. The renal rOCT1, rOCT2 and rMATE1 and hepatic rMATE1 levels were increased in hyperuricemic rats compared with those in control rats, respectively. The in vitro study showed that uric acid could upregulate the expression of OCT2 and MATE1 in HEK293 cells and MATE1 in HepaRG cells and increase the intracellular metformin concentration in these two cell lines. These results demonstrated that a high uric acid level promoted urinary metformin excretion and decreased the plasma metformin concentration; the in vivo and in vitro studies provided a possible explanation being that high uric acid could upregulate the expression of renal metformin transporters OCTs and MATE1.
Calcination Atmosphere Regulated Morphology and Catalytic Performance of Pt/SiO2 in Gas‐phase Oxidative Dehydrogenation of KA‐oil
Authors: Hong Wei , Wang Zhi‐Qiang , Zou Shihui , Zhou Yuheng , Lu Linfang , Zhou Qiuyue , Gong Xue‐Qing , Fan Jie 
Published: November 2018

AbstractIt is industrially attractive to produce cyclohexanone directly from gas‐phase oxidative dehydrogenation (ODH) of KA‐oil (a mixture of cyclohexanone and cyclohexanol) since extra alcohol‐ketone separation process can be potentially omitted. Herein, by simply tuning the calcination atmosphere of Pt/SiO2, we successfully regulated the morphology of Pt nanoparticles and optimized their catalytic performance in ODH of KA‐oil. Pt/SiO2 calcined in O2 atmosphere showed a cube‐like morphology and achieved a 78.1 % cyclohexanone yield at 170 °C, which surpassed its counterpart calcined in H2 and most of the reported catalysts. Further experimental and theoretical calculation results indicated that cubic Pt nanoparticles possessed stronger adsorption ability to cyclohexanol and therefore performed better in ODH of KA‐oil.
Design and Conception of a Membrane Pilot Plant for the In Situ Treatment of Bioleaching Solutions
Authors: Werner Arite , Haseneder Roland , Repke Jens‐Uwe 
Published: November 2018

AbstractToday's mining activities are facing deposits of decreasing metal content and an increase of complexity. Biohydrometallurgy is an industrial application that uses microorganisms to facilitate the release of metals from mineral ores, especially sulfide ores. A testing site for in situ bioleaching was established in an underground mine to recover indium and germanium from a zinc sulfide ore vein. The downstream processing of the pregnant leaching solution is also realized as in situ application by means of a membrane pilot plant, which was exclusively designed for this special application.
A hybrid CPU‐GPU‐MIC algorithm for minimal hitting set enumeration
Authors: Carastan‐Santos Danilo , Martins‐Jr David C. , Song Siang W. , Rozante Luiz C.S. , de Camargo Raphael Y. 
Published: November 2018

SummaryWe present a hybrid exact algorithm for the Minimal Hitting Set (MHS) Enumeration Problem for highly heterogeneous CPU‐GPU‐MIC platforms. With several techniques that permit an efficient exploitation of each architecture, low communication cost, and effective load balancing, we were able to enumerate MHSs for large instances in reasonable time, achieving good performance and scalability. We obtained speedups of up to 25.32 in comparison with using two six‐core CPUs and we also enumerated MHSs for instances with tens of thousands of variables in less than 5 hours. We also evaluated our algorithm with a real‐world driven dataset, and with a large CPU‐GPU cluster, we unprecedentedly enumerated in parallel large minimal hitting sets of this dataset in less than 8 hours. These results reinforce the statement that heterogeneous clusters of CPUs, GPUs, and MICs can be used efficiently for high‐performance computing.
UHPLC‐MS Analyses of Plant Flavonoids
Authors: Lei Zhentian , Sumner Barbara W. , Bhatia Anil , Sarma Saurav J. , Sumner Lloyd W. 
Published: November 2018

AbstractFlavonoids are a class of specialized metabolites found in many different plant species. They protect against UV radiation, scavenge reactive oxygen species, are involved in plant defense responses, and are associated with plant‐microorganism interactions. They have also been reported to possess health‐promoting effects including anti‐inflammatory, antioxidant, anticancer activity, and antihypertensive effects. Flavonoids encompass >10,000 structures where the types and amounts depend on the plant species, developmental stage, organ, and growth conditions. The diversity of flavonoid structures represents a significant challenge in the analysis of plant flavonoids. Many analytical techniques have been developed to detect and quantify flavonoids, and the most productive of these techniques use liquid chromatography (LC) coupled to mass spectrometry (MS) to analyze flavonoids due to the excellent combination of selectivity and sensitivity of MS. In addition, mass spectral libraries have been constructed to further aid flavonoid identification. Here, the use of ultra‐high pressure liquid chromatography coupled to mass spectrometry (UHPLC‐MS) in plant flavonoid analyses, with an emphasis on sample extraction, flavonoid separation, and MS detection, is described. © 2018 by John Wiley & Sons, Inc.
World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grading in fine‐needle aspiration biopsies of renal masses
Authors: Perrino Carmen M. , Cramer Harvey M. , Chen Shaoxiong , Idrees Muhammad T. , Wu Howard H. 
Published: November 2018

BackgroundUtilization of fine‐needle aspiration (FNA) biopsy for the evaluation of renal masses has been increasing at our institution. At times diagnostic material on direct smears is superior to that in the cell block/core biopsy, therefore assigning an accurate nuclear grade in the cytopathology report would provide useful prognostic information.MethodsSearch of the pathology database identified renal FNAs performed during an 11‐year period (2006–2017). Corresponding core biopsies and resections were identified. Cases with a diagnosis of primary renal neoplasia on FNA, core biopsy, and/or resection were included. Two pathologists reviewed all cases and assigned a World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grade to each FNA, core biopsy, and resection case.ResultsA total of 162 kidney FNAs were identified. Primary renal neoplasia was diagnosed in 137 cases on core biopsy/resection. Among diagnostic FNAs of clear cell RCC and papillary RCC with core biopsy/resection specimens for re‐review (n = 52), reviewers assigned a concordant WHO/ISUP grade to 83% (43/52) of cases. Among 9 cases with discrepant scores, all had a discrepancy of 1 grade and were undergraded on FNA. Using a two tier grading system (low vs. high grade), reviewers assigned a concordant grade to 88% (46/52) of cases. Among 6 cases with discrepant scores, all were classified as low grade (WHO/ISUP grade 2) on FNA versus high grade (WHO/ISUP grade 3) on resection.ConclusionThe WHO/ISUP grade assigned on FNA shows good concordance with subsequent resection/core specimens (83%), with all discrepant cases being undergraded by one grade.
Thai Tea Seed (Camellia oleifera) Oil Favorably Affects Plasma Lipid Responses in Hamsters Fed High‐Fat Diets
Authors: Suealek Nuchanart , Yokoyama Wallace H. , Rojpibulstit Panadda , Holt Roberta R. , Hackman Robert M. 
Published: November 2018

Coronary heart disease (CHD) is the leading cause of death worldwide. Dietary inclusion of monounsaturated fatty acids (MUFA) such as olive oil (OO) can reduce CHD risk. Tea seed oil (TSO) from Camellia oleifera grown in Thailand, with a MUFA content similar to OO, may be an alternative to OO when a higher cooking smoke point is desired. The lipid profiles, liver histology, and serum chemistries of hamsters fed high‐fat diets (TSO, OO, grape seed oil or butter; 14% by weight) are analyzed. After three weeks of feeding, TSO and OO groups have similar plasma low‐density lipoprotein cholesterol (LDL‐C), very‐low‐density lipoprotein cholesterol (VLDL‐C), triacylglycerols (TAG), high‐density lipoprotein cholesterol (HDL‐C), and total cholesterol (TC) levels. Moreover, TC/HDL‐C and LDL‐C/HDL‐ C ratios are also comparable. Similar to the OO group, the TSO group has significantly lower plasma LDL‐C, VLDL‐C, TAG, TC, and a lower TC/ HDL‐C ratio as compared to the butter group. Some minor liver pathological lesions commonly found in rodents fed high‐fat diets are observed. Thai TSO may be a healthy option for cooking, and clinical studies are warranted.Practical Applications: With its high smoking point, TSO is attractive to Asian consumers for their styles of cuisine. As it is produced locally, its price is cheaper than imported OO. This study demonstrates TSO's health benefits in lowering lipid profiles similar to OO. Based on this fact, this study supports Thai TSO cultivation in northern Thailand as a means of increasing rural villagers’ income.Hamsters are divided into five groups: tea seed oil, olive oil, grape seed oil, low fat, and butter. Tea seed oil favorably lowers plasma low‐density lipoprotein cholesterol (LDL‐C) in hamsters fed high‐fat diets.
Sensitive Determination of Terbutaline Using a Platform Based on Nanoparticles of Europium Oxide and Carbon Nanotubes
Authors: Teker Tuğçe , Aslanoglu Mehmet 
Published: November 2018

AbstractThis study presents a sensitive voltammetric determination of terbutaline (TER) on a platform based on carbon nanotubes (CNTs) and europium oxide nanoparticles (Eu2O3NPs) coated glassy carbon electrodes (GCEs). An ultrasonic bath was performed for the preparation of composite material. The material was characterized by energy dispersive X‐ray spectroscopy (EDX), X‐ray diffraction method (XRD) and scanning electron microscopy (SEM). The Eu2O3NPs/CNTs/GCE system was assessed for the oxidation of terbutaline (TER). A broad oxidation peak was appeared at 0.71 V using a bare GCE. However, the voltammetry of TER has been improved at a GCE coated with CNTs and a well‐defined anodic peak exhibited at 0.61 V. Furthermore, the nanoparticles of Eu2O3 and CNTs coated GCE has greatly improved the electrochemical behaviour of TER and a sharp peak was appeared at 0.59 V. Cyclic voltammetry at Eu2O3NPs/CNTs/GCE also reveals a high catalytic effect for the oxidation of TER with an oxidation peak that is distinctly enhanced compared to GCE and CNTs/GCE. Eu2O3 nanoparticles were utilized to enhance the surface area of GCE and then improve the sensitivity of the procedure. The response of TER was linear over a concentration range of 2.0×10−8 M −9.5×10−6 M with an LOD of 3.7×10−9 M. Square wave voltammetric analysis of tablets by Eu2O3NPs/CNTs/GCE yielded a recovery of 99.2 % with an RSD% of 3.2. The modified electrode (EuO2NPs/CNTs/GCE) provides accuracy and precision to the analysis of samples.
BisPNA‐assisted Detection of Double‐stranded DNA via Electrochemical Impedance Spectroscopy
Authors: Liu Qianrui , Ma Kefeng , Wen Dongxiao , Sun Haobo , Wang Qiangwei , Kong Jinming , Qiu Yunliang , Li Lianzhi , Chen Wuqiao 
Published: November 2018

AbstractA highly effective strategy for quantification of plasmid which was a special dsDNA based on bisPNA by electrochemical impedance spectroscopy was presented in this work. Firstly, through Au−S bond, thiol‐terminated bisPNA probes were immobilized onto the gold electrode surface. Then bisPNA probes directly hybridized with target plasmid DNA pBR322 based on the PNA.DNA‐PNA invasion triplex without denaturation. In the presence of redox electroactive ions [Fe(CN)6]3−/4− as hybridization indicator, the charge transfer resistance (Rct) was produced, and Rct was measured via electrochemical impedance spectroscopy. Under optimal conditions, this strategy showed a good linear relationship between the ΔRct which was the difference of Rct obtained before and after bisPNA hybridized with plasmid pBR322, and logarithm of the concentration of plasmid pBR322 within the range from 1 nM to 100 nM (R2=0.993), with a limit of detection (LOD) of 0.1 nM. Furthermore, this bisPNA‐assisted biosensor showed good stability and satisfactory analytical reliability. In addition, this novel bisPNA‐assisted biosensor also exhibited excellent analytical results in human serum.
Joint user association, subchannel assignment, and power allocation in full‐duplex OFDMA heterogeneous networks
Authors: Dehghani Firouzabadi Abbas , Rabiei Amir Masoud 
Published: November 2018

AbstractIn‐band full‐duplex (FD) radio is regarded as a promising solution to enhance the spectral efficiency in the next‐generation wireless networks. In this paper, the problem of joint user association, subchannel assignment, and power allocation in FD orthogonal frequency‐division multiple access heterogeneous networks is considered. The weighted downlink and uplink sum rate of the network is maximized in a way that the transmit power of base stations and users remains below a given level. The problem is formulated as a nonconvex mixed‐integer nonlinear programming optimization problem. Then, it is converted into a suboptimal problem, which can be solved iteratively using difference of convex programming algorithm. Numerical results show that the proposed iterative algorithm converges quickly in few numbers of iterations with different initialization points. The results also show that the sum rate of an FD heterogeneous network can be as much as 66 % higher than the sum rate of a half‐duplex network.
Project Octo‐Pills—Engaging community pharmacists in the care of patients from a tertiary hospital: A pilot study
Authors: Neo Zhi Yang , Low Yi Ting , Ong Kheng Yong , Chong Joy Boon Ka , Lim Kiat Wee , Chan Max Wei , Lim Anson Zong Neng , Mamun Kaysar , Chen Li Li 
Published: November 2018

SummaryObjectiveTo evaluate the effectiveness of a pilot model engaging community pharmacists in the collaborative care of patients from a tertiary hospital, in terms of identification and resolution of drug‐related problems (DRPs), and patients' acceptance and satisfaction with the program.MethodsA prospective case series was conducted. Eligible patients were recruited from the tertiary hospital and referred to their preferred community pharmacy for medication reconciliation, review, and counseling. The number and types of DRP identified and resolved during or after the medication review were collated. A patient survey was conducted upon completion of the study.ResultsA total of 32 participants completed the study. A total of 63 DRPs were identified from 379 medications reviewed, and 60 (95.2%) were resolved by the community pharmacists. Failure to receive drug (n = 21, 33.3%) and drug interactions (n = 11, 17.5%) were the most common DRPs. Survey feedback indicated that the service was well received.ConclusionIn this model, community pharmacists can play an important role in identifying and resolving DRPs by providing patients with medication reconciliation and review services from a more convenient location within their neighborhood.
From Oasis Archipelago to Pioneering Eldorado in Algeria's Sahara
Authors: Amichi F. , Bouarfa S. , Kuper M. , Caron P. 
Published: November 2018

AbstractSince the 1980s, the Biskra region in Algeria's Sahara has undergone rapid agricultural change leading to territorial transformation. Horticultural production under greenhouses, associated with a rapid expansion of date palm plantations, has led to a tangible agricultural boom that is constantly pushing the boundaries of agricultural production and constitutes a true pioneering fringe. To understand the pioneering logics at work, we propose to study the pioneer fringe through three fronts, namely land, water and infrastructure. First, we analyse each front separately in order to understand its logic. In a second step, through three illustrations, we show how these fronts interpenetrate, accelerate one another or, on the contrary, constrain the pioneer fringe. The analysis of the advance of the pioneering fringe has shown that it results from the interweaving of the three main fronts and each of these combines both the actions of the state and private initiative. © 2018 John Wiley & Sons, Ltd.
Meaningful Writing Opportunities: Write‐Alouds and Dialogue Journaling With Newcomer and English Learner High Schoolers
Authors: Linares Rebecca E. 
Published: November 2018

AbstractThe author explores how one teacher at a newcomer school (a school for recently arrived immigrants) used dialogue journaling and write‐alouds as instructional and community‐building tools in her work with multilingual ninth‐grade students with limited or interrupted formal education in their home countries. The analysis shows how the focal teacher used dialogue journaling to engage students in meaningful writing opportunities that identified and built background knowledge and facilitated context‐rich literacy instruction through accompanying scaffolded write‐alouds in which comprehensible input was provided. The author concludes with recommendations for how other teachers of language learners can utilize write‐alouds and dialogue journaling in their instruction of culturally and linguistically diverse students.