bluuebunny/crossref_metadata_2025_split huggingface dataset:
Father involvement and emotion regulation during early childhood: a systematic review
Authors: Puglisi Nilo , Rattaz Valentine , Favez Nicolas , Tissot Hervé 
Published: November 2024

Abstract
Background
Father involvement, defined in terms of both the quantity and quality of ways in which fathers may be involved, affects the child’s development. How specifically father involvement links to emotion regulation during early childhood (0–5 years) is, however, less clear.

Methods
This literature review synthesizes research on the links between father involvement and emotion regulation during early childhood, as well as the measurement methods used to assess them. Ten relevant studies were identified via four databases (up to August 2023).

Results
Results showed no significant direct links, but significant links appeared between high father involvement and more adaptive emotion regulation when moderated by variables related to the assessment of father involvement and emotion regulation, as well as the characteristics of the father and the child.

Conclusions
Future research should continue to use observational measures of father behaviors and child emotion regulation, increase the use of physiological measures of emotion regulation, and consider the influence of maternal and family variables.
Resveratrol inhibits ferroptosis in the lung tissues of heat stroke-induced rats via the Nrf2 pathway
Authors: Du Liwen , Zhu Xueqi , Jiang Zhenluo , Wang Weidong , Liu Peng , Zhu Leilei , Zhang Fangqi 
Published: November 2024

Abstract
Background
Heat stroke (HS) can lead to the development of pulmonary ferroptosis. The inhibition of pulmonary ferroptosis during HS improves patient prognosis. The aim of this study was to investigate the effects of resveratrol (RES) on heat stress at an ambient temperature of 42 °C.

Methods
Heat stress was induced in Beas-2B cells and lung injury was induced in HS rats at an ambient temperature of 42 °C. The anti-oxidative stress and anti-ferroptotic effects of RES were confirmed through tail vein injection of nuclear factor-2 associated factor (Nrf2) shRNA recombinant adeno-associated virus 6 (AAV6-shNrf2).

Results
RES treatment attenuated the upregulation of reactive oxygen species (ROS) and malondialdehyde (MDA) levels and alleviated glutathione inhibition in HS. In addition, RES treatment reduced the accumulation of Fe2+ in heat-stressed Beas-2B cells and increased the ferroptosis resistance-related proteins FTH1, GPX4, and SLC7A11 as well as the anti-oxidative stress pathway proteins Nrf2, NQO1, and HO-1. The antioxidant and anti-ferroptotic effects of RES in heat-stressed Beas-2B cells were effectively reversed upon treatment with Nrf2-IN-1, an Nrf2 pathway inhibitor. In the HS rat model, the antioxidant and anti-ferroptotic effects of RES were reversed by an ambient temperature of 42 °C and relative humidity of 60 ± 5%.

Conclusions
RES effectively protected HS rats from lung injury, inhibited the accumulation of Fe2+, ROS, and MDA in the lung, and upregulated FTH1, GPX4, SLC7A11, Nrf2, NQO1, and HO-1.

Graphical Abstract
Barriers and facilitators to healthcare facility utilization by non-Ebola patients during the 2018–2020 Ebola outbreak in the Democratic Republic of Congo
Authors: Kyomba Gabriel Kalombe , Law Michael Robert , Grépin Karen Ann , Mayaka Serge Manitu , Mambu Thérèse Nyangi-Mondo , Mbunga Branly Kilola , Hategeka Celestin , Mapatano Mala Ali , Konde Joël Nkiama-Numbi , Ngo-Bebe Dosithée , Babakazo Pélagie Diambalula , Mafuta Eric Musalu , Kiyombo Guillaume Mbela 
Published: November 2024

Abstract
Background
An Ebola Virus Disease (EVD) outbreak occurred in North Kivu between 2018 and 2020. This eastern province of the Democratic Republic of Congo was also grappling with insecurity caused by several armed groups. This study aimed to explore the barriers and facilitators to utilizing Healthcare Facilities (HCFs) by non-Ebola patients during the crisis.

Methods
A qualitative case study was conducted in Beni and Butembo with 24 relatives of 15 deceased non-EVD patients, 47 key informants from healthcare workers (HCWs), as well as community leaders. Semi-structured interviews were conducted to explore three key areas: (i) the participants’ illness history, care pathway, care, and social support; (ii) their perceptions of how EVD affected the care outcome; and (iii) their opinions on the preparedness, supply, use, and quality of healthcare before and during the outbreak. All interviews were recorded, transcribed verbatim, and thematically analysed using Atlas-ti 8.0.

Results
Nine of the 15 deaths were female and their ages ranged from 7 to 79 years. The causes of death were non-communicable (13) or infectious (2) diseases. Conspiracy theories, failure to establish security, and the concept of the ''Ebola business'' were associated with misinformation and lower levels of trust in government and HCFs. The negative perceptions, fear of being identified as an Ebola case, apprehension about the triage unit, and inadequacy of personal protective equipment resulted in a preference for private or informal HCFs. For half of the deceased’s relatives, the Ebola outbreak hastened their death. Conversely, community involvement, employing familiar, neutral, and credible HCWs, and implementing a free care policy increased the number of visits. These results were observable despite a lack of funds, overstretched HCWs, and long waiting time.

Conclusions
Our findings can inform policies before and during future outbreaks to enhance the resilience of routine HCFs by maintaining dialogue between HCWs and patients, and rebuilding confidence in HCFs. Quantitative studies including context analysis are essential to identify the determinants of care-seeking during such a crisis.
Impact of access to coronary angiography and percutaneous coronary intervention on in-hospital and five-year mortality in patients with acute coronary syndrome: a propensity-matched cohort study in Thailand
Authors: Kumwichar Ponlagrit , Thungthong Jutatip , Liabsuetrakul Tippawan , Tachimori Hisateru , Hosozawa Mariko , Saito Eiko , Taniguchi Yuta , Chongsuvivatwong Virasakdi , Iso Hiroyasu 
Published: November 2024

Abstract
Background
Coronary artery angiography (CAG) and percutaneous coronary intervention (PCI) are superior to non-invasive approaches in reducing mortality in patients with ST-segment elevation myocardial infarction (STEMI). However, their efficacy remains uncertain in non-ST-elevation acute coronary syndromes (NSTE-ACS) and limited in low-resource settings. This study aimed to compare in-hospital and 5-year mortality rates between patients with a first event of STEMI and NSTE-ACS who underwent CAG and PCI and those with similar severity who did not undergo CAG and PCI.

Methods
A propensity-matched retrospective cohort study was conducted using population-based claims data of national universal coverage of Thailand for identification of patients with acute coronary syndromes. The mortality of recruited patients was additionally linked to the national database of vital registration. Patients aged ≥ 40 years who were hospitalized for STEMI and NSTE-ACS in 2017, with a focus on access to CAG and PCI were included. For each condition either STEMI or NSTE-ACS, patients who underwent CAG and PCI were matched to those who did not undergo using propensity score matching (PSM) to balance measured confounders, such as age, sex, and underlying conditions. In-hospital mortality rate ratio and 5-year mortality were analyzed as measures.

Results
Through PSM, 2,702 non-intervention STEMI patients were paired with an equal number of intervention patients, and similarly, 5,072 non-intervention NSTE-ACS patients were matched with an equivalent group who received interventions. For patients with STEMI, the in-hospital mortality rate ratio (95% confidence interval (CI)) for those who underwent CAG and PCI compared to those who did not was 30.1% (30.0%, 30.2%). Similar trends were observed in patients with NSTE-ACS with a mortality rate of 34.7% (34.6%, 34.8%). For the five-year mortality comparison, the hazard ratios (95% CI) of mortality after discharge were 0.55 (0.50, 0.62) for STEMI and 0.57 (0.54, 0.61) for NSTE-ACS cases.

Conclusions
Access to CAG and PCI was significantly associated with lower in-hospital and 5-year mortality rates in patients who experienced their first event of ACS, despite the limited availability of some unmeasured or residual confounders. Healthcare systems should expand their resources for CAG and PCI in Thailand and other countries to equitably enhance longevity.
Knowledge and perception of physiotherapy among healthcare science students at the Maldives National University
Authors: Qayyoom Isna Abdul , Suhail Ammar 
Published: November 2024

Abstract
Introduction
Physiotherapy is a crucial profession of interdisciplinary medical team, in which healthcare professionals need to comprehend the duties of other members in the team to offer a holistic management to the patients. Healthcare professionals who uphold negative beliefs and perceptions about other healthcare professions can be a barrier to ‘patient- centered’ approach. Nevertheless, there is a paucity of research on knowledge and awareness of physiotherapy by healthcare professionals or students. There has been no study conducted in the Maldives to investigate the knowledge and perception of physiotherapy by healthcare students. Therefore, the aim of the study was to explore the knowledge and perceptions among healthcare science students at The Maldives National University (MNU).

Methods
A cross-sectional study was conducted at the Faculty of Health Sciences (FHS), School of Nursing (SN), and School of Medicine (SM). A stratified random sampling method was adopted to recruit the participants. A self-administered questionnaire was used to obtain the data from the participants. The data was analyzed using the SPSS version 25.

Results
A total of 318 students from three different schools and faculties of MNU participated in the study. The mean age of the respondents was 23 ± 4, with 89.9% being female. The overall K-score of 12 indicated poor knowledge, whereas the P-score of 10 reflected a positive perception among the participants, with no significant difference observed between genders. The Kruska-Wallis test indicated a significant difference in K-score across courses and years of study enrolled.

Conclusion
This study’s findings revealed a disparity between healthcare students’ positive perception towards physiotherapy and their lack of knowledge regarding the profession, indicating barriers to knowledge acquisition. Significant differences were found between different healthcare courses and years of study.
Eggplant turbinoplasty: how I do it
Authors: Abdel-Aziz Mosaad , Nassar Ahmed , Yousef Ahmed Ibrahim , Sabry Omar Aly 
Published: November 2024

Key points1. The inferior turbinate is a static structure with a dynamic function as it plays a major role in the formation of nasal valve and laminar airflow.2. The inferior turbinate resembles an eggplant: it has head, body, and tail; and it is formed of 3 layers which are an outer covering mucosa, an intermediate submucosal connective tissue, and an inner bony concha.3. Eggplant turbinoplasty technique involves removal of the infero-lateral part of the inferior turbinate longitudinally.4. The excised part consists of soft tissue and bone, and the raw area is covered with a medial soft tissue flap.5. The medial turbinate mucosa is preserved which is very important for warming and humidification of the inspired air.6. The procedure decreases the size of the turbinate without major changes in the shape to maintain the laminar airflow.7. Intraoperative bleeding is usually minimal as the inferior turbinate artery enters the turbinate through its upper surface.8. Postoperative crustations is avoided as the raw area is completely covered with a medial soft tissue flap.9. The procedure does not need special equipments.10. This turbinate reduction technique respects both the anatomical shape to maintain normal laminar airflow, and the physiologic concepts with preserving the medial mucosa for airway protection.
The Role of Amphiphilic Compounds in Nasal Nanoparticles
Authors: Quoc Thinh To , Bíró Krisztina , Pető Ágota , Kósa Dóra , Haimhoffer Ádám , Lekli István , Pallér Ádám , Bak István , Gyöngyösi Alexandra , Fehér Pálma , Bácskay Ildikó , Ujhelyi Zoltán 
Published: November 2024

AbstractNasal medications hold significant importance and are widely utilized due to their numerous advantageous properties, offering a compelling route for both local and systemic therapeutic effects. Nowadays, the development of nasal particles under 1 micrometer is in the focus of much scientific research. In our experiments, the use of innovative nanotechnology to increase the effectiveness of the active substance was of paramount importance. Our aim was to create solid nanoparticles that enable targeted and effective delivery of the active ingredient into the body. The innovation of this experimental series lies not only in highlighting the importance of amphiphilic compounds in enhancing penetration, but also in the fact that while most nasally administered formulations are in liquid form, our formulation is solid. Liquid formulations frequently suffer from the disadvantage of possible leakage during administration, which can reduce the bioavailability of the active ingredient. In our experiments we created novel drug delivery systems of finely divided powders, which, thanks to the penetration enhancers, can be successfully administered. These enhancers facilitate the swift disintegration and penetration of the particles through the membrane. This represents a new direction in nasal drug delivery methods. The results of our trials are promising in the development of innovative pharmaceutical products and outline the role of amphiphilic compounds in more efficient utilization and targeted application of active substances. According to our results it can be concluded that this innovative approach not only addresses the common issues associated with liquid nasal formulations but also paves the way for more stable and effective delivery methods. The use of finely divided powders for nasal delivery, enabled by penetration enhancers, represents a major breakthrough in the field, providing a dependable alternative to conventional liquid formulations and ensuring improved therapeutic results.
Graphical Abstract
Multispectral Fluorescence Imaging as a Tool to Distinguish Pelvic Lymphatic Drainage Patterns During Robot-assisted Lymph Node Dissection in Prostate Cancer
Authors: Berrens Anne-Claire , Buckle Tessa , van Oosterom Matthias N. , Slof Leon J. , van Leeuwen Pim J. , Wit Esther M. K. , de Barros Hilda A. , Nieuwenhuijzen Jakko A. , Bekers Elise M. , Donswijk Maarten L. , van Leeuwen Fijs W. B. , van der Poel Henk G. 
Published: November 2024

Abstract
Background
The invasive nature of extended pelvic lymph node dissection (ePLND) prompts the need for alternative lymphatic mapping technologies. To change the focus to “sparing nodes that are not involved,” the first step is to research the feasibility of intraoperatively distinguishing the lymph drainage patterns of the prostate from healthy organs.

Methods
We performed a prospective study (NCT05120973) that included 16 patients who underwent a robot-assisted radical prostatectomy + ePLND + sentinel node (using indocyanine green-99mTc-nanocolloid). After general anesthesia, a second fluorescent dye (fluorescein) was injected unilaterally in two deposits into the intradermis of the upper leg (n = 8) or abdominal wall (n = 8), because these are the most common locations of lymphedema in prostate cancer surgery. To distinguish between the drainage patterns, in vivo and ex vivo multispectral fluorescence imaging was performed by using a fluorescence endoscope.

Results
Indocyanine green and fluorescein were visible in the same regions within the ePLND-template and co-accumulated in lymph vessels in vivo. At histopathology, fluorescein was seen in only 10 of 370 lymph nodes (possibly owing to tracer properties), none of which overlapped with indocyanine green and none were tumor-positive. Administration of fluorescein did not result in discomfort or abnormal postoperative recovery.

Conclusions
Multispectral imaging can be used to distinguish lymphatic drainage patterns. Our in vivo findings indicate that within the ePLND-template, lymphatic drainage patterns of the prostate at least partly overlap with those of upper leg and abdominal wall. The properties of fluorescein render it unsuitable for confirmation of fluorescence at histopathology.
Strożyska wieś z okresu późnego średniowiecza w Dolinie Nidy
Authors: Lewek Konrad , Mazur Anna , Mazur Krzysztof 
Published: November 2024

Dear Reader, in your hands you are holding a work that is a detailed study of archaeological monuments from the medieval village of Strożyska. Here you will find detailed information about the discovered remains of houses, pits and places associated with production (workshops). Medieval material products such as elements of clothing, tools, everyday objects and – the most common – ceramic products were also taken into account. A lot of attention was paid to the subject of the production of vessels, of which several thousand fragments were found. All of them were described, and a significant part was graphically edited. Based on their analysis, it was possible to obtain a handful of information about medieval rural pottery production. This is all the more important because this subject has not been discussed in the context of the Świętokrzyskie Voivodeship so far. Excavations in Strożyska, conducted in the so-called rescue mode, show how much valuable evidence of past times is still hidden underground and how methodical study of them allows us to learn about our past.
Badanie środowiska przyrodniczego w naukach humanistycznych, społecznych i przyrodniczych
Authors: Piasek Wojciech , Oliński Piotr , Kleśta-Nawrocki Rafał 
Published: November 2024

This is the next volume in the series "Nature – Homines – History" which contains articles addressing the issue of nature as a subject of research that is located inter – between, among various scientific disciplines. One of the problems noticed in the study of the natural environment is the hermetic nature of the language of the disciplines that undertake studies on it. This is an inevitable phenomenon that escalates with the development of science, the growing number of different specialisations and increasingly diverse scientific methods. It also has a deeper cause, resulting from the functioning of researchers in different thinking styles. However, this does not exempt researchers from building the most comprehensive possible picture of various problems that are key to reality within one thinking style or from the obligation to seek platforms of scientific communication between different styles. Another problem is related to the opening of disciplinary boundaries, which has intensified the phenomenon of various connections between disciplinary “orders” in nature studies, which so far have built their object of knowledge and methods on the principle of opposition – humanities, social sciences, and natural sciences. This is undoubtedly most visible in posthumanism. Among the authors of the volume are representatives of such disciplines as history, archival studies, ethnology and cultural anthropology, cultural studies, geography, and geology.
Ultra-high numerical aperture waveguide-integrated meta beam shaper
Authors: Iyer Hrishikesh , Vlasov Yurii 
Published: November 2024

The integration of metasurfaces with guided mode sources like waveguides has opened new frontiers for on-chip optical integration. However, the state-of-the-art in the field has targeted applications where long focal distances over thousands of light wavelengths are needed. This regime where the paraxial approximation holds enables inverse design of metasurfaces with weakly confining elements that are typically thicker than the wavelength in the material. For short focal length applications at distances less than 100λ, where the paraxial approximation fails and high numerical apertures (NAs) are necessary, a different approach is required. Here, we designed and experimentally demonstrated single-mode waveguide-integrated meta beam shapers capable of redirecting the confined light into the free space and focusing it at focal distances less than 100λ above the chip surface into a tightly focused spot. Focal spot characteristics measured at 460 nm operating wavelength approach diffraction-limited focusing across a range of focal lengths, device footprints, and numerical apertures, demonstrating the robustness of the approach. Focal volumes smaller than 1µm3 are demonstrated for a range of focal distances below 50 µm (100λ). For a device with NA of 0.95 that is one of the highest amongst integrated metasurfaces, the measured focal volume is as small as just 0.06µm3 at a focal distance of 13µm (28λ). These on-chip integrated ultra-high NA meta beam shapers have the potential to unlock new applications in quantum optical computing with trapped ions, localized optogenetic neurostimulation, and high resolution in situ microscopy.
A comparison of the diagnostic capability of Kato-Katz and real-time PCR for the assessment of treatment efficacy of ivermectin and albendazole combination against T. trichiura infections
Authors: Matamoros Gabriela , Sanchez Ana , Cimino Ruben , Krolewiecki Alejandro , Mejia Rojelio 
Published: November 2024

Background
Trichuris trichiura is humans’ second most prevalent soil-transmitted helminth (STH) infection after Ascaris lumbricoides, affecting approximately 460 million people worldwide. Despite its sub-optimal sensitivity, especially in low prevalence and infection intensity settings, the modified Kato-Katz (K-K) is still recommended as a diagnostic method by the World Health organization (WHO) guidelines.

Methodology/principal findings
Within a randomized clinical trial (RCT) comprising four treatment arms with two different anthelmintics, the present study reports an important secondary research objective to determine the diagnostic agreement between K-K and real-time PCR evaluating treatment efficacy against T. trichiura. The parasitological results were analyzed, including cure rates (CR) of a subgroup of 94 participants positive at baseline for T. trichiura eggs for both techniques. The single-dose albendazole (ALB) arm resulted in significantly lower CRs than experimental arms of albendazole/ivermectin (ALB/IVM) combinations. The overall diagnostic agreement between both techniques was 88.7% [κ = 0.8 (P<0.001)]. Concordance between eggs per gram and Ct values was moderate, with the discordance source likely stemming from lighter infection intensities.

Conclusions and significance
These findings indicate that real-time PCR is a suitable alternative for CR estimation in helminthiasis clinical trials. It also highlights the need to identify the most accurate diagnostic tools for RCTs, that would benefit from guiding principles to achieve harmonization across studies and are not necessarily the same as those used for epidemiological surveys.

Trial registration
Clinical Trials.gov (NCT04041453)