bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scrub Typhus – An Overlooked Aetiology for Acute Febrile Illness in Bangladesh: A Case Report
Authors: Zaman Shahana , Rashid Lubna , Rahim Muhammad Abdur 
Published: January 2019

Rickettsial fevers are a heterogeneous group of illness characterized by fever, headache, myalgia and rash. Rickettsia has a wide global distribution and regional species specificity. In spite of significant serosurveillance reports, rickettsial fevers are occasionally reported in Bangladesh. Here, we report a case of scrub typhus occurring in a young girl who presented with fever and had a typical eschar. We emphasize rickettsial fever should be a differential diagnosis in acute fever without localizing symptoms and signs in Bangladesh.
Birdem Med J 2019; 9(1): 80-81
Central Venous Stenosis in a Patient on Maintenance Hemodialysis: A Case Report
Authors: Latif Tanveer Bin , Mohammad Jan 
Published: January 2019

A 57-year-old male patient of chronic kidney disease on maintenance hemodialysis via right radio-cephalic fistula presented with swelling of his right arm and right half of face and headache. With the clinical suspicion of central venous obstruction he underwent venogram of right upper limb. A stenosis was found in right brachiocephalic vein. He underwent a percutaneous transluminal balloon angioplasty and his symptoms improved substantially.
Birdem Med J 2019; 9(1): 82-84
Acute Promyelocytic Leukaemia with Differentiation Syndrome Treated Successfully with ATRA-ATO Therapy: A Case Study
Authors: Uddin Mohammed Mosleh , Mahfuz Huque , Karim Md Mostafil , Rahman Md Mizanur , Sultana Syeda Adib 
Published: January 2019

Acute promyelocytic leukemia (APML) is the first malignant disease highly curable with targeted therapy directed at a unique molecular abnormality. The characteristic bleeding diathesis due to the combined effect of thrombocytopenia and disseminated intravascular coagulation is the most notorious manifestation of the disease, which historically has accepted for high mortality rate during induction. Acute promyelocytic leukemia is one of the few hematologic diseases that can be diagnosed with certainty by morphological examination of blood film and bone marrow aspirate by the practicing hematologist. Such step facilitates early institution of all-trans retinoic acid (ATRA) before molecular confirmation of the diagnosis. Therefore, ATRA therapy as well as aggressive blood product support is critical to reduce early mortality. Early diagnosis and prompt institution of appropriate therapy is essential as APML is a medical emergency and without rapid management patient may succumb due to bleeding diathesis. Also the prognosis of APML is much better than other subtypes of acute myeloid leukemia. ATRA plus anthracycline based chemotherapy for induction and consolidation followed by maintenance ATRA with low dose chemotherapy is currently the standard of care. However the combination of ATRA and arsenic trioxide (ATO), with minimal chemotherapy to control leukocytosis, is very effective therapy for newly diagnosed APML patients. The combination may replace conventional approaches to most, if not all, patients in the very near future. Here we report a case of APML of female who got admitted with fever, cough and pupuric rash throughout the whole body.
Birdem Med J 2019; 9(1): 85-88
Ulcerative Colitis in a Bangladeshi Child: A Case Report
Authors: Hoque Nazmul , Ahmed Shireen , Zaman Taslima 
Published: January 2019

Introduction: Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder of colon. Ulcerative colitis is uncommon in tropics and sub-tropics. We describe a case of pediatric ulcerative colitis with successful treatment. A 4-years-old girl who presented with passage of loose bloody stool, abdominal pain and mild arthralgia along with significant weight loss. Her height was 95 cm, and weight was 13 kg. Diagnosis was confirmed by colonoscopy and histopathology. Treatment was thereafter started with parenteral steroid initially then oral steroid and mesalamine. The patient is now on remission and is on regular follow up. UC is rare in Bangladesh, especially in children. Several conditions like infective colitis, allergic colitis, Meckel’s diverticulitis, Crohn’s disease, etc. may mimic the features of UC. So, if a child presents with recurrent bloody diarrhea, UC should be considered as a differential diagnosis.
Birdem Med J 2019; 9(1): 89-94
A potential estrogen receptor inhibitor compound 34 induces apoptosis via ROS-independent intrinsic apoptosis in MCF-7 cells
Authors: Ding Ruru , Zhu Ziying , Teng Mengting , Ma Lin , Hu Jiaying , Hu Jiangbiao , Zhang Peng 
Published: January 2019

This study aimed to investigate the anti-tumor effects of compound 34 on MCF-7 cells in vitro, and explore its mechanisms. MTT results showed that compound 34 selectively inhibited estrogen receptor-positive cells proliferation. Hoechst 33342 staining showed nuclear pyknosis, nuclear debris associated with apoptotic bodies. JC-1 staining showed the loss of mitochondrial membrane potential. Although compound 34 increased intracellular reactive oxygen species (ROS), compound 34-induced apoptosis was not prevented by pretreatment with ROS scavengers. Western blotting showed apoptosis-related protein like cytochrome c and cleaved PARP protein increased. Furthermore, docking studies exhibited that compound 34 could bind into ERα. In summary, compound 34 selectively inhibited estrogen receptor positive cells proliferation and induced apoptosis in MCF-7 cells via ROS-independent intrinsic apoptosis in MCF-7 cells. It may be a potential targeted drug of estrogen receptor for therapeutic application of breast cancer.
Video Clip of Methodology:
Assay of Cell Proliferation: 5 min 5 sec Full Screen Alternate
Management of Meconium Ileus: 5 years' experience at Dhaka Shishu (Children) Hospital
Authors: Ferdous Kazi Md Noor ul , Hasan Md Samiul , Kabir Kh Ahsanul , Islam M Kabirul , Banu Tahmina 
Published: January 2019

Background : Meconium ileus (MI) is one of the common cause of intestinal obstruction in neonate. It can be present with various complications (about 50%) like volvulus, atresia, and gangrene of the gut, perforation and meconium cyst.
Objective : This study aimed to compare various surgical procedures used in the treatment of meconium ileus and to assess their efficacy regarding survival and complications in our center.
Methods : This retrospective study was done to all cases of meconium ileus admitted in the Department of neonatal surgery of Dhaka Shishu (Children) Hospital during the past 5 years (2011 to2016). The medical records of all patients with meconium ileus were studied. The surgical procedures were Mikulicz procedure, Bishop-Koop procedure done in case of complicated cases and Mikulicz procedure, Bishop-Koop and T tube ileostomy done in uncomplicated cases. Outcomes were compared between complicated and uncomplicated group and between the surgical procedures.
Results : Total patients were 224. Among them 8 were excluded due to incomplete data. The mean age was 3.23 days. Twenty four neonates were preterm. Fifty-two percent were uncomplicatedMI and 48.15% were complicated. Among 112 uncomplicated cases, Mikulicz procedure done in 33 cases, Bishop-Koop procedure done in 37 cases and rest were treated by T tube ileostomy procedures. Among 104 cases of complicated meconium ileus, Mikulicz procedure done in 75 cases and 42 cases were treated by Bishop-Koop stoma. Predominant complications in Mikulicz procedures were high output fistula (67.6%), sepsis (34.84%) and skin excoriation (58.33%), while in Bishop-Koop procedure were sepsis (59.25%), anastomotic leak and reoperation (25.75%). In T tube ileostomy, complications were intra-peritoneal leak with reoperation and sepsis (9.52%). Twenty five (11.6%) stoma prolapse were found in Mikulicz ileostomy. The overall mortality of meconium ileus was 36.6%, in simple MI 23 out of 112 and in complicated MI 56 out of 104. This difference was significant.
Conclusion : Considering the study result we concluded that complications occur more frequently in Mikulicz procedure and it is significantly associated with mortality, Bishop- Koop ileostomy can be considered but anastomotic leak is still an important complication of this procedure. In uncomplicated cases T tube ileostomy found as the best option.
Northern International Medical College Journal Vol.10(1) Jul 2018: 326-329
Faktor-Faktor Penyebab dan Strategi Penanggulangan Angka Putus Sekolah di Kabupaten Luwu Utara
Authors: Ali Sidin , Nur Hamsah 
Published: January 2019

Penelitian ini bertujuan untuk mendapatkan gambaran angka putus sekolah, faktor-faktor penyebab anak putus sekolah, dan strategi yang dapat dilakukan untuk menanggulangi anak putus sekolah di Kabupaten Luwu Utara. Penelitian ini menggunakan pendekatan kuantitatif dengan metode deskriptif. Pengumpulan data dilakukan melalui lembar observasi, pedoman wawancara, lembar angket, dan dokumentasi. Analisis data menggunakan analisis deskriptif. Hasil penelitian menunjukkan bahwa: (1) Angka putus sekolah APS SD/MI = 0,05%, APS SMP/MTs = 0,10%, dan APS SMA/MA/SMK = 0,30%; angka partisipasi kasar APKSD/MI = 100,31%, APKSMP/MTs = 100,02%, dan APKSMA/MA/SMK = 90,01%; dan angka partisipasi murni APMSD/MI= 99,99%, APMSMP/MTs= 92,12%, dan APMSMA/MA/SMK= 68,37% (2) faktor penyebab anak putus sekolah di Kabupaten Luwu Utara adalah: faktor ekonomi, pendidikan orang tua, faktor lingkungan (lingkungan keluarga, lingkungan sekolah, lingkungan masyarakat), faktor budaya, dan faktor minat serta motivasi anak itu sendiri; (3) strategi yang dapat dilakukan untuk menanggulangi anak putus sekolah di Kabupaten Luwu Utara adalah: advokasi, pemberian beasiswa, pemeliharaan/pemanfaatan ruang kelas, penambahan/ pemeliharaan fasilitas belajar, penambahan RKB dan USB, penambahan/perbaikan sarana dan prasarana, model-model sekolah (sekolah kunjungan, SD-SMP satap, sekolah terapung, sekolah kecil), dan kejar paket.
Kajian Pengembangan Lingkungan Sehat di Kabupaten Luwu Utara
Authors: Ardi Muhamad , Amir Faizal , Suti Marsus , Ardiansa Muhammad Awaluddin 
Published: January 2019

Lingkungan Sehat adalah salah satu aspek pembangunan dalam rangka meningkatkan kesejahteraan masyarakat. Penelitian ini bertujuan untuk mengetahui : (1) gambaran sanitasi lingkungan, (2) upaya-upaya yang dilakukan masyarakat, (3) faktor pendukung dan penghambat pengembangan lingkungan sehat, dan (4) rumusan kebijakan pengembangan lingkungan sehat di Kabupaten Luwu Utara. Pendekatan penelitian yang dilakukan adalah penelitian survei. Wilayah penelitian dipilih dengan metode purpossive sampling. Responden penelitian sebanyak 200 kepala keluarga dipilih dengan metode Systematic random sampling. pengumpulan data dilakukan dengan melakukan observasi dan memberikan kuesioner kepada responden. Analisis data yang digunakan adalah analisis deskriptif. Hasil penelitian yang diperoleh adalah: (1) Sanitasi lingkungan kecenderungannya sudah baik, namun masih perlu ditingkatkan; (2) Upaya yang dilakukan masyarakat dalam mengembangkan lingkungan sehat sudah baik, namun masih banyak aspek lingkungan yang perlu ditingkatkan; (3) Faktor pendukung dalam pengembangan lingkungan sehat adalah: motivasi, sikap, subsidi pemerintah, pendapatan msyarakat yang baik, dan budaya hidup bersih; (4) Faktor penghambat pengembangan lingkungan sehat adalah: tingkat pendidikan dan pendapatan masyarakat yang rendah, serta budaya hidup masayarakat yang kurang peduli terhadap lingkungan; (5) Strategi yang dilakukan untuk mengembangkan lingkungan sehat secara berkelanjutan adalah: (a) melakukan penyuluhan lingkungan, (b) memberikan pelatihan dan percontohan sanitasi lingkungan yang sehat, (c) memberikan subsidi pada masyarakat untuk meningkatkan sanitasi lingkungan, terutama bagi masyarakat yang tingkat pendidikan, penadapatan rendah, serta masyarakat yang kurang pedui terhadap lingkungan yang sehat.
Penjadwalan Agenda Pelaksanaan Tridharma Perguruan Tinggi Secara Online Menggunakan Google Calendar
Authors: Raharja Untung , Lutfiani Ninda , Wardana Wahyu Setya 
Published: January 2019

Majunya perkembangan teknologi yang berjalan saat ini berdampak cukup besar dengan kehidupan manusia sehari-hari. Tidak terkecuali pada bidang pendidikan. Saat ini banyak sekali perubahan perubahan yang ditunjang oleh berbagai teknologi baru. Banyak pula penunjang untuk mempermudah kegiatan pendidikan. Salah satunya yaitu kalender. Tidak hanya digunakan untuk melihat tanggal bulan dan tahun, kalender ternyata memiliki berbagai fungsi lainnya. Yaitu salah satunya berfungsi sebagai pengingat atau reminder. Selain itu bisa digunakan untuk membuat note atau catatan pada hari tersebut. Dari berbagai macam aktivitas atau kegiatan yang kita akan dan sedang dilakukan dapat di buat kan catatan dan pengingat dari setiap kegiatan tersebut. Setiap jadwal atau reminder yang sudah dibuat dapat juga menampilkan notifikasi pengingatnya. Penggunaan google calendar pun dapat digunakan oleh berbagai kalangan mulai dari murid Sekolah sampai Orang Tua sekali pun baik personal maupun kelompok atau organisasi. Penggunaanya juga terbilang mudah karena user interface nya yang userfriendly.Kata kunci: Agenda Online Tridharma Google Calendar, Tridharma, Google Calendar.
Peralihan Hak Atas Tanah Berdasarkan Pewarisan Pada Golongan II Karena Tanpa Keturunan
Authors: Nawawie A. Hasyim 
Published: January 2019

One reason for expiration of one's ownership of land is due to death. Due to the existence of this legal event resulting shift in wealth from the people who died, both material and inmaterial wealth to the heirs of the deceased. With the death of someone this then there will be the heir, the heir and wealth. Heir is the person who died and left property, while the heirs are entitled to the wealth of the people died. And possessions left behind could be immaterial and material, material wealth, among others, land, houses or other objects. Inheritance is a law governing the heritage property of someone who has died is given to the beneficiary, such as families and communities more right. Inheritance law in force in Indonesia there are three namely: Customary Inheritance Law, Inheritance Law and Inheritance Law Civil Islam. Each region has different laws according to which they profess kekerababatan system. Heir in group II under Article 854, 855, 856 and Article 857 of the Civil Code. According to Article 854 of class II legacy earned for own rights, whereas under Article 855 to Article 857 obtained due to switch places. Group II consists of father, mother and brothers heir.

Salah satu sebab berakhirnya kepemilikan seseorang atas tanah adalah karena kematian. Karena dengan adanya peristiwa hukum ini mengakibatkan adanya peralihan harta kekayaan dari orang yang meninggal, baik harta kekayaan material maupun immaterial kepada ahli waris orang yang meninggal tersebut. Dengan meninggalnya seseorang ini maka akan ada pewaris, ahli waris dan harta kekayaan. Pewaris adalah orang yang meninggal dunia dan meninggalkan harta kekayaan, sedangkan ahli waris adalah orang yang berhak atas harta kekayaan dari orang meninggal. Dan harta kekayaan yang ditinggalkan bisa immaterial maupun material, harta kekayaan material antara lain tanah, rumah ataupun benda lainnya. Hukum waris adalah suatu hukum yang mengatur peninggalan harta seseorang yang telah meninggal dunia diberikan kepada yang berhak, seperti keluarga dan masyarakat yang lebih berhak. Hukum waris yang berlaku di Indonesia ada tiga yakni: hukum waris adat, hukum waris Islam dan hukum waris perdata. Setiap daerah memiliki hukum yang berbeda-beda sesuai dengan sistem kekerabatan yang mereka anut. Ahli waris pada golongan II diatur dalam Pasal 854, 855, 856 dan Pasal 857 KUHPerdata. Menurut Pasal 854 warisan golongan II diperoleh karena haknya sendiri, sedangkan menurut Pasal 855 sampai Pasal 857 diperoleh karena pergantian tempat. Golongan II terdiri dari ayah, ibu serta saudara-saudara si pewaris.
Isolasi Kapang Pendegradasi Hidrocarbon Dari Limbah Minyak Bumi PT. Ollop Bula
Authors: Rijal Muhammad 
Published: January 2019

AbstrakTingginya aktivitas penambangan minyak lepas pantai mengakibatkan terjadinya pencemaran air oleh tumpahan minyak bumi mentah, sehingga berdampah terhadap kerusakan ekosistem. Secara alami tumpahan minya dilepas pantai dapat hilang oleh aktivitas mikroorganisme. Kapang merupakan salah satu mikroorganisme yang memiliki kemapuan dalam mendegradasi hydrocarbon. Hasil penelitian diperoleh 6 isolat kapang yang memiliki kemampuan dalam mendegradasi hydrocarbon. Isolat V memiliki kemauan yang lebih kuat dan isolat I memiliki kemampuan yang paling lemah dalam mendegradasi hydrocarbon. Kata kunci: kapang, isolat, hydrocarbon AbstractThe high activity of offshore mining cause water pollution by crude petroleum spill thus impacts the ecosystem damage. Naturally, offshore oil spills can be lost by microorganism activities. Kapang (mold) is one of microorganisms having an ability to degrade hydrocarbon. The research result found 6 isolates of kapang having the ability to degrade hydrocarbon. Isolate V had stronger ability, whereas isolate I was the weaker in degrading hydrocarbon. Keywords: molds, isolates, hydrocarbon
Studi Manajemen Persediaan Just In Time pada Proyek Konstruksi Gedung KPP Menteng
Authors: Ahadian Edward Rizky 
Published: January 2019

AbstrakJIT merupakan filosofi produksi yang dikembangkan oleh Toyota Motor dan berhasil membuat industri otomotif dan elektronika Jepang menjadi industri yang mampu bekerja secara efisien dengan mutu keluaran yang baik. Keberhasilan JIT dibidang industri manufaktur telah mendorong industri lainnya termasuk industri konstruksi untuk mengadopsinya. JIT berusaha untuk menghilangkan sumber-sumber pemborosan produksi dengan cara menerima jumlah yang tepat dari material dan memproduksinya dalam jumlah yang tepat pada tempat yang tepat dan waktu yang tepat. Studi terhadap metode Just In Time ini dilakukan dengan menggunakan studi kasus terhadap proyek konstruksi pembangunan gedung Kantor Pusat Pajak (KPP) Menteng dengan Kontraktor pelaksana PT. Pembangunan Perumahan (PT.PP). Adapun studi JIT inventory management didasarkan pada tiga aspek kajian, yaitu kebijakan perusahaan dalam pengelolaan persediaan, sistem pemesanan dan penerimaan material. Hasil menunjukkan bahwa telah dilakukan pengelolaan persediaan dengan pendekatan JIT dalam proses produksi proyek KPP Menteng dengan sedikit modifikasi pada prinsip JIT. Beberapa modifikasi tersebut antara lain yaitu adanya buffer sebagai antisipasi terhadap variasi yang ada, hal ini berlawanan dengan prinsip dasar dari JIT yaitu menghilangkan buffer. Upaya-upaya yang dilakukan oleh PT. PP melalui kebijakan maupun sistem pemesanan dan penerimaan material untuk mengurangi pemborosan sejalan dengan metode JIT. Kata kunci: JIT Inventory management, proyek konstruksi gedung, ROP, Safety stock, Lead time AbstractJIT is a production philosophy developed by Toyota Motor and it successes in making the automotive and electronics industries in Jepang to be an efficient industry with good quality output. The success of JIT in manufacturing industry has encouraged other industries, including construction, to adopt it. JIT tries to eliminate production waste sources by receiving an exact number of materials and producing in an exact number at the right place and time. Study on JIT method was conducted using a case study on a construction project of the development of Tax Office (KPP) Menteng building with the contractor of PT. Pembangunan Perumahan (PT.PP). The study of JIT inventory management was based on three study aspects, namely, company policy in inventory management, material ordering system and material receiving system. The result indicated that JIT-approached inventory management had been conducted in the production process of KPP Menteng project with small modification on its principles. Some of the modifications were, such as, the existence of buffer as an anticipation of existing variation, which was in contrast to the basic principle of JIT, which is eliminating buffer. Efforts conducted by PT. PP through its policy or material ordering and receiving systems to reduce waste were in line with the JIT method. Keywords: JIT Inventory management, building construction project, ROP, Safety stock, Lead time
Aplikasi Metode Importancae Performance Analysis dalan Analisa Tingkat Pelayanan Mode Speedboat
Authors: Gaus Abdul , Anwar Chaerul , Putra Sutrisno 
Published: January 2019

AbstrakSpeedboat merupakan salah satu moda yang mengbungkan pusat kota Ternate dengan pusat kota Tidore Kepulauan. Meningkatnya pelaku perjalanan menggunakan moda ini menuntut perlunya perhatian terhadap aspek kenyamanan dan keselamatan pengguna moda. Kondisi di lapangan menunjukkan bahwa moda speedboat beraktivitas pada siang maupun malam hari, pada berbagai cuaca dan mengangkut bukan hanya manusia namun juga barang. Penelitian ini bertujuan untuk menganalisis tingkat pelayanan speedboat menurut penilain pengguna moda menggunakan metode analisis Importance Performance Analysis (IPA). IPA digunakan untuk memetakan hubungan antara importance (kepentingan) dengan performance (kinerja) dari masing-masing atribut pelayanan menurut penilaian penumpang speedboat Ternate-Tidore. Tingkat pelayanan moda transportasi speedboat Ternate-Tidore menggunakan metode IPA didapatkan variabel yang memiliki kepentingan/Harapan yang tinggi namun pada kinerja/realita tidak cukup baik, yaitu variabel penerangan di malam hari, ketersediaan baju pelampung/life jacket dan ketersediaan kotak P3K. Sedangkan variabel yang dianggap kurang penting oleh penumpang, tetapi kinerjanya baik sehingga penumpang menganggap kinerja tersebut berlebihan, yaitu variabel layanan informasi dan tarif speedboat, ketersediaan pelontar . Kata kunci— Speedboat, Moda Transportasi, Importance Performance Analysis AbstractSpeedboat is one of transportation modes connecting the city central of Ternate to the city central of Tidore Island. The increase in travellers who use the mode requires attention on the aspect of comfort and safety of the mode users. Field condition indicates that speedboat mode starts active at noon and night in various weathers. The mode is not only transported people but also goods. The research aimed to analyze the speedboat service level based on the appraisal from the mode users using Importance Performance Analysis (IPA) method. IPA used to map the relationship between the importance and performance of each service attribute according to the appraisal of the passengers of Ternate-Tidore speedboat. The service level of Ternate-Tidore speedboat transportation mode using IPA method indicated that there were variables with high importance/expectation but less performance/reality, which were night lighting variable, the availability of life jacket and first aid box, whereas, variables considered as less important by the passengers but had good performance so that passengers regarded them as overwhelmed were information service variable, speedboat rate, and the availability of thrower. Keywords — Speedboat, Transportation Mode, Importance Performance Analysis