bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravenous Bone Marrow Mononuclear Cells for Acute Ischemic Stroke: Safety, Feasibility, and Effect Size from a Phase I Clinical Trial
Authors: Vahidy Farhaan S. , Haque Muhammad E. , Rahbar Mohammad H. , Zhu Hongjian , Rowan Paul , Aisiku Imoigele P. , Lee Dean A. , Juneja Harinder S. , Alderman Susan , Barreto Andrew D. , Suarez Jose I. , Bambhroliya Arvind , Hasan Khader M. , Kassam Mallikarjuna Rao , Aronowski Jaroslaw , Gee Adrian , Cox Charles S. , Grotta James C. , Savitz Sean I. 
Published: September 2019

AbstractCellular therapy is a promising investigational modality to enhance poststroke recovery. We conducted a single-arm, phase I clinical trial to determine the safety and feasibility of intravenous (IV) administration of autologous bone marrow mononuclear cells (MNCs) after acute ischemic stroke (AIS). Patients with moderate severity of AIS underwent bone marrow harvest followed by IV reinfusion of MNCs within 24–72 hours of onset. A target dose of 10 million cells per kilogram was chosen based on preclinical data. Patients were followed up daily during hospitalization and at 1, 3, 6, 12, and 24 months for incidence of adverse events using laboratory, clinical (12 months), and radiological (24 months) parameters. The trial was powered to detect severe adverse events (SAEs) with incidences of at least 10% and planned to enroll 30 patients. Primary outcomes were study-related SAEs and the proportion of patients successfully completing study intervention. A propensity score-based matched control group was used for the estimation of effect size (ES) for day-90 modified Rankin score (mRS). There were no study-related SAEs and, based on a futility analysis, enrolment was stopped after 25 patients. All patients successfully completed study intervention and most received the target dose. Secondary analysis estimated the ES to be a reduction of 1 point (95% confidence interval: 0.33–1.67) in median day-90 mRS for treated patients as compared with the matched control group. Bone marrow harvest and infusion of MNCs is safe and feasible in patients with AIS. The estimated ES is helpful in designing future randomized controlled trials. Stem Cells 2019;37:1481–1491
Fostering intra‐BRICS trade and investment: The increasing role of China in the Brazilian and South African economies
Authors: Gouvea Raul , Kapelianis Dimitri , Li Shihong 
Published: September 2019

AbstractIn the past two decades, Brazil, South Africa and China have designed closer economic and political ties. Since the early 2000s, China has become a key economic partner for both countries. International trade and foreign direct investment between the three nations have expanded, and closer political ties have also evolved. This article elaborates on the increasing economic interdependence between Brazil, China, and South Africa addressing challenges and opportunities for all three countries involved.
Physico‐chemical processes
Authors: Ouyang Weihang , Chen Tianhao , Shi Yihao , Tong Liangyu , Chen Yangyu , Wang Weiwen , Yang Jiajun , Xue Jinkai 
Published: September 2019

AbstractThe review scans research articles published in 2018 on physico‐chemical processes for water and wastewater treatment. The paper includes eight sections, that is, membrane technology, granular filtration, flotation, adsorption, coagulation/flocculation, capacitive deionization, ion exchange, and oxidation. The membrane technology section further divides into six parts, including microfiltration, ultrafiltration, nanofiltration, reverse osmosis/forward osmosis, and membrane distillation.Practitioner points

Totally 266 articles on water and wastewater treatment have been scanned;

The review is sectioned into 8 major parts;

Membrane technology has drawn the widest attention from the research community.
The accuracy of self-report versus objective assessment for estimating socioeconomic inequalities in disease prevalence in Indonesia
Authors: Mulyanto Joko , Kringos Dionne S. , Kunst Anton E. 
Published: September 2019

Abstract

Objectives
To estimate socioeconomic inequalities in hypertension and asthma prevalence in Indonesia, to compare estimates based on self-report (SR) to those based on objective assessment (OA), and to assess the role of sensitivity and specificity of SR.

Methods
We used data from the 2014 Indonesia Family Life Survey (n = 34,257). We measured inequalities in hypertension and asthma prevalence in relation to educational level and income, using standardised prevalence rate and the relative index of inequality (RII). Using OA as standard, we calculated the sensitivity and specificity of SR.

Results
For hypertension, reversed inequalities were found when estimated by SR instead of OA (RII for education 0.86, 95% CI 0.74–0.99 vs. RII 1.29, 95% CI 1.16–1.44). For asthma, a similar but even larger reversal of inequalities was found. The sensitivity of SR was low overall, and especially for the lowest education or income group.

Conclusions
Results imply that the use of SR may lead to underestimation of socioeconomic inequalities in disease prevalence in a low-income country such as Indonesia. The use of OA is recommended for monitoring inequalities in non-communicable disease prevalence.
Induction of tumor-specific CD8+ cytotoxic T lymphocytes from naïve human T cells by using Mycobacterium-derived mycolic acid and lipoarabinomannan-stimulated dendritic cells
Authors: Tomita Yuji , Watanabe Eri , Shimizu Masumi , Negishi Yasuyuki , Kondo Yukihiro , Takahashi Hidemi 
Published: September 2019

Abstract
The main effectors in tumor control are the class I MHC molecule-restricted CD8+ cytotoxic T lymphocytes (CTLs). Tumor-specific CTL induction can be regulated by dendritic cells (DCs) expressing both tumor-derived epitopes and co-stimulatory molecules. Immunosuppressive tolerogenic DCs, having down-regulated co-stimulatory molecules, are seen within the tumor mass and can suppress tumor-specific CTL induction. The tolerogenic DCs expressing down-regulated XCR1+CD141+ appear to be induced by tumor-derived soluble factors or dexamethasone, while the immunogenic DCs usually express XCR1+CD141+ molecules with a cross-presentation function in humans. Thus, if tolerogenic DCs can be reactivated into immunogenic DCs with sufficient co-stimulatory molecules, tumor-specific CD8+ CTLs can be primed and activated in vivo. In the present study, we converted human tolerogenic CD141+ DCs with enhanced co-stimulatory molecule expression of CD40, CD80, and CD86 through stimulation with non-toxic mycobacterial lipids such as mycolic acid (MA) and lipoarabinomannan (LAM), which synergistically enhanced both co-stimulatory molecule expression and interleukin (IL)-12 secretion by XCR1+CD141+ DCs. Moreover, MA and LAM-stimulated DCs captured tumor antigens and presented tumor epitope(s) in association with class I MHCs and sufficient upregulated co-stimulatory molecules to prime naïve CD3+ T cells to become CD8+ tumor-specific CTLs. Repeat CD141+ DC stimulation with MA and LAM augmented the secretion of IL-12. These findings provide us a new method for altering the tumor environment by converting tolerogenic DCs to immunogenic DCs with MA and LAM from Mycobacterium tuberculosis.
Traction Injury of Recurrent Laryngeal Nerve During Thyroidectomy
Authors: Liu Meng‐Yu , Chang Chun‐Ping , Hung Chien‐Ling , Hung Chung‐Jye , Huang Shih‐Ming 
Published: September 2019

AbstractBackgroundLoss of the neuromonitoring signal (LOS) during thyroidectomy signifies recurrent laryngeal nerve (RLN) injury, which is one of the common complications, especially by traction injury. Transient intraoperative LOS means spontaneous recovery of nerve function during surgery or within 6‐month post‐surgery. Few articles discuss intraoperative recovery time and transient LOS, and there is no consensus on the risk factors for RLN traction injury and its recovery course; thus, we wanted to determine the maximum intraoperative recovery time.Materials and methodsThis retrospective study included patients who had undergone thyroidectomies at Tainan National Cheng Kung University Hospital between January 2015 and August 2018. A total of 775 patients (with 1000 nerves at risk) who underwent intermittent intraoperative neuromonitoring during thyroidectomy were included in this study. The LOS nerves were divided into 4 groups based on the LOS subtype and the intraoperative status of the recovery. The postoperative vocal cord function was determined by thyroid ultrasound and/or laryngoscope. All the patients would be followed up postoperatively in 2–3 days, 1 week, 2 weeks, and 4–6 weeks.ResultsLOS occurred in 67 of 775 (8.6%) patients and in 70 of 1000 nerves at risk (7.0%). There were 2 in 70 nerves (2.9%) with LOS type 1 (segmental nerve traction injury) with intraoperative recovery (Group 1), 5 (7.1%) with LOS type 1 without intraoperative recovery (Group 2), 47 (67.1%) with LOS type 2 (global injury) with intraoperative recovery (Group 3), and 16 (22.8%) with LOS type 2 without intraoperative recovery (Group 4). All LOS type 1 (segmental nerve injury) nerves had pathologic lesions near the RLN or vagus nerve, but none had invaded the nerves (p < 0.05). The resolving time intraoperatively in the 2 patients in Group 1 was 5 min and 10 min, respectively. The resolving time intraoperatively in Group 3 was 1–20 min, and the average time was 4.8 min. In Group 2, 3 injured nerves recovered within 6 weeks postoperatively, and 2 nerves in 12 weeks. In Group 4, all the 16 injured nerves recovered within 6 weeks postoperatively.ConclusionApplying intermittent intraoperative neuromonitoring during thyroidectomy, traction recurrent laryngeal nerve injury still happened in 7.0%. 70% of the injured nerves recovered the function intraoperatively after releasing the traction, and the longest duration of recovery is 20 min.
Surgical Outcomes in Acute Mesenteric Ischemia: Has Anything Changed Over the Years?
Authors: Acosta‐Mérida María Asunción , Marchena‐Gómez Joaquín , Saavedra‐Santana Pedro , Silvestre‐Rodríguez José , Artiles‐Armas Manuel , Callejón‐Cara María Mar 
Published: September 2019

AbstractBackgroundDespite increases in knowledge and advances in the management of acute mesenteric ischemia syndrome (AMI), there have been no significant improvements in mortality in recent years. The objective of this study was to assess the changes in clinical characteristics and surgical outcomes in patients who underwent AMI over time.MethodsA total of 323 consecutive patients who underwent acute mesenteric ischemia at our institution between 1990 and 2015 were examined. The occurrence of significant changes over this 25‐year period in demographic data, comorbidity, clinical characteristics, laboratory results, operative findings, etiology of the AMI, and operative mortality were evaluated. The evolution mortality rates for the studied period were analyzed using the additive logistic regression, and the significant effect was determined using the Akaike Information Criterion (AIC).ResultsA significant increasing linear trend was observed in recent years in Charlson score values (p = 0.008), antiplatelet drug intake (p < 0.001), use of CT scan (p < 0.001), arterial thrombosis (p < 0.001), and intestinal resection (p = 0.047), while a decreasing linear trend was observed in digoxin intake (p < 0.001), angiography use (p = 0.004), and embolia (p < 0.001). The rest of the parameters did not present changes over time. Regarding the evolution of the adjusted surgical mortality, a significant decrease according the AIC criterion was observed.ConclusionsIn recent years, the characteristics of patients with AMI requiring surgery have changed. Changes in operative mortality have also been detected, showing a tendency toward a progressive and significant decrease.
Hydrodynamic interaction of bubbles rising side-by-side in viscous liquids
Authors: Kong G , Mirsandi H. , Buist K. A. , Peters E. A. J. F. , Baltussen M. W. , Kuipers J. A. M. 
Published: September 2019

AbstractDetailed experiments are conducted to study hydrodynamic effects of two simultaneously released bubbles rising in viscous liquids. Different types of interactions are observed as a function of the liquid viscosities, leading to different bubble shapes, ranging from rigid spheres and spheroids to deformable spheroids. Bubble velocities are obtained by an automated smooth spline technique, which allows for an accurate calculation of the lift and drag forces. The results obtained for spherical bubbles are in agreement with predictions of Legendre et al. (J Fluid Mech 497:133–166, 2003). The observations of deformed bubbles show that a very small equilibrium distance can be established due to the induced torque arising from the deformation. In terms of the lateral interaction, different separation distances can be observed depending on the initial distance. For deformable bubbles, the results are limited to a qualitative analysis due to limitations of the processing technique to handle strong shape irregularities. Nevertheless, the observations reveal that the deformation plays an important role with respect to bubble interactions and path instability of which the latter can be triggered by the presence of other bubbles.Graphic abstract
Correction to: Transmission of the frequency components of the vibrational signal of the glassy-winged sharpshooter, Homalodisca vitripennis, within and between grapevines
Authors: Gordon Shira D. , Tiller Benjamin , Windmill James F. C. , Krugner Rodrigo , Narins Peter M. 
Published: September 2019

Unfortunately, Fig. 3 was incorrectly published in the original publication. The correct version of Fig. 3 is updated here.
Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults
Authors: Chen Yung-Chih , Smith Harry A. , Hengist Aaron , Chrzanowski-Smith Oliver J. , Mikkelsen Ulla Ramer , Carroll Harriet A. , Betts James A. , Thompson Dylan , Saunders John , Gonzalez Javier T. 
Published: September 2019

Abstract

Purpose
To examine whether calcium type and co-ingestion with protein alter gut hormone availability.

Methods
Healthy adults aged 26 ± 7 years (mean ± SD) completed three randomized, double-blind, crossover studies. In all studies, arterialized blood was sampled postprandially over 120 min to determine GLP-1, GIP and PYY responses, alongside appetite ratings, energy expenditure and blood pressure. In study 1 (n = 20), three treatments matched for total calcium content (1058 mg) were compared: calcium citrate (CALCITR); milk minerals rich in calcium (MILK MINERALS); and milk minerals rich in calcium plus co-ingestion of 50 g whey protein hydrolysate (MILK MINERALS + PROTEIN). In study 2 (n = 6), 50 g whey protein hydrolysate (PROTEIN) was compared to MILK MINERALS + PROTEIN. In study 3 (n = 6), MILK MINERALS was compared to the vehicle of ingestion (water plus sucralose; CONTROL).

Results
MILK MINERALS + PROTEIN increased GLP-1 incremental area under the curve (iAUC) by ~ ninefold (43.7 ± 11.1 pmol L−1 120 min; p < 0.001) versus both CALCITR and MILK MINERALS, with no difference detected between CALCITR (6.6 ± 3.7 pmol L−1 120 min) and MILK MINERALS (5.3 ± 3.5 pmol L−1 120 min; p > 0.999). MILK MINERALS + PROTEIN produced a GLP-1 iAUC ~ 25% greater than PROTEIN (p = 0.024; mean difference: 9.1 ± 6.9 pmol L−1 120 min), whereas the difference between MILK MINERALS versus CONTROL was small and non-significant (p = 0.098; mean difference: 4.2 ± 5.1 pmol L−1 120 min).

Conclusions
When ingested alone, milk minerals rich in calcium do not increase GLP-1 secretion compared to calcium citrate. Co-ingesting high-dose whey protein hydrolysate with milk minerals rich in calcium increases postprandial GLP-1 concentrations to some of the highest physiological levels ever reported. Registered at ClinicalTrials.gov: NCT03232034, NCT03370484, NCT03370497.
Genetically encoded FRET-based optical sensor for Hg2+ detection and intracellular imaging in living cells
Authors: Soleja Neha , Jairajpuri Mohamad Aman , Queen Aarfa , Mohsin Mohd 
Published: September 2019

Abstract
Due to the potential toxicity of mercury, there is an immediate need to understand its uptake, transport and flux within living cells. Conventional techniques used to analyze Hg2+ are invasive, involve high cost and are less sensitive. In the present study, a highly efficient genetically encoded mercury FRET sensor (MerFS) was developed to measure the cellular dynamics of Hg2+ at trace level in real time. To construct MerFS, the periplasmic mercury-binding protein MerP was sandwiched between enhanced cyan fluorescent protein (ECFP) and venus. MerFS is pH stable, offers a measurable fluorescent signal and binds to Hg2+ with high sensitivity and selectivity. Mutant MerFS-51 binds with an apparent affinity (K d) of 5.09 × 10−7 M, thus providing a detection range for Hg2+ quantification between 0.210 µM and 1.196 µM. Furthermore, MerFS-51 was targeted to Escherichia coli (E. coli), yeast and human embryonic kidney (HEK)-293T cells that allowed dynamic measurement of intracellular Hg2+ concentration with a highly responsive saturation curve, proving its potential application in cellular systems.
Synthesis of a New Chloro Antimony Complex with Pyridinium Derivative: Crystal Structure, Hirshfeld Surface Analysis, Vibrational, and Optical Properties
Authors: Elleuch Nour , Fredj Donia , Chniba-Boudjada Nassira , Boujelbene Mohamed 
Published: September 2019

Abstract
The new organic–inorganic hybrid material (C6H7N2S)2[SbCl4]Cl was synthesized by slow evaporation method and characterized by single-crystal X-ray diffraction, infrared absorption, Hirshfeld surface analysis, optical absorption and photoluminescence measurements. The Centro symmetric compound crystallizes in the triclinic system of space group $${\text{P}}\bar{1}$$P1¯ with two formula units cell (Z = 2).The crystal structure is composed of a discrete [SbCl4]− anion and two isolated chloride Cl− anions which carried the same negative charge to balance the total charge of this compound surrounded by the 4 pyridiniumethioamide cations. Organic and inorganic parts which are linked by means of hydrogen bonding contacts N–H···Cl with N···Cl length are varied in the range of 3.221–3.456 Å to form a Zero-dimensional network. The infrared study performed at room temperature charge in the 4000–400 cm−1 frequency regions confirms the existence of the organic cation [C6H7N2S]+ and that of the [SbCl4]− anion. The Photoluminescence spectrum exhibits a broad and strong band of luminescence located at 1.95 eV (635 nm), which can be even observed with the naked eye at room temperature and is due to exaction emission. The various intermolecular interactions of the two independent cations and six chloride atoms were examined via Hirshfeld surface analysis.
Qualitätszielfunktionen für stark variierende Gemeindegrößen im Zensus 2021
Authors: Burgard Jan Pablo , Münnich Ralf , Rupp Martin 
Published: September 2019

Zusammenfassung
Am 24. Oktober 2017 wurden beim Bundesverfassungsgericht die Normenkontrollklagen der Länder Berlin und Hamburg im Bezug auf das Zensusgesetz 2011 verhandelt. Ein zentraler Gegenstand der Klagen war eine methodische Ungleichbehandlung von Gemeinden unterschiedlicher Größe bei der Einwohnerzahlermittlung im Zensus 2011, da für Gemeinden kleiner als 10.000 Einwohner eine andere Methodik angewendet wurde als für Gemeinden mit mehr als 10.000 Einwohnern. Diese Grenze wurde im Zensusgesetz für den Zensus 2011 festgeschrieben und ist nach Bekanntwerden der Zensusergebnisse kritisiert worden. Im vorliegenden Beitrag werden verschiedene Möglichkeiten diskutiert, wie beim Zensus 2021 auf einen Methodenwechsel, wie er im Jahr 2011 stattfand, verzichtet werden kann und wie dahingehend die Methodik geeignet angepasst werden muss. Einen besonderen Schwerpunkt nimmt hierbei eine Adjustierung der Qualitätsmessung, die sogenannten Präzisionsvorgaben, ein. Eine Definition dieser für eine stichprobenbasierte Zensuserhebung muss insbesondere im Hinblick auf die Gemeindegröße geeignet gewählt werden. Zudem bedarf es einer Untersuchung der Auswirkung der Qualitätsmessung auf die regionalen Stichprobenumfänge und auf die Qualität der später zu schätzenden Einwohnerzahl. In den Untersuchungen werden methodische und praktische Überlegungen berücksichtigt.
Bio-economic analysis of super-intensive closed shrimp farming and improvement of management plans: a case study in Japan
Authors: Shinji Junpei , Nohara Setsuo , Yagi Nobuyuki , Wilder Marcy 
Published: September 2019

AbstractCrustacean aquaculture is a multibillion-dollar industry worldwide that continues to show significant growth. Shrimp farming has been intensified for decades, and super-intensive closed culture systems have now been developed to improve productivity and reduce environmental burdens. Here, we used bio-economic approaches to investigate the mechanisms and economic productivity of shrimp farming. We used three steps: (1) path analysis by using structural equation models to determine the candidate factors associated with productivity; (2) modeling of population dynamics and profits; and (3) simulations based on the models to clarify the productive characteristics of a super-intensive closed culture system. Our findings suggest that the population dynamics of the system were limited by unidentified factors that differed from those found in many experimental studies, such as water temperature, salinity, dissolved oxygen, and nitrogenous waste. The unidentified factors were related to the number of days of rearing and cumulative biomass mortality. The production plan suggested by our simulation required frequent culture rotation to increase profits. Our case study provides important practical information about the characteristics of super-intensive shrimp farming, implications for efficient economic management, and new research subjects for the future.
Use of aminated hulls of sunflower seeds for the removal of anionic dyes from aqueous solutions
Authors: Jóźwiak T. , Filipkowska U. , Brym S. , Kopeć L. 
Published: September 2019

Abstract
In this study, we analyzed the effectiveness of sorption of dyes popular in the textile industry (Reactive Black 5, Reactive Yellow 84, Acid Yellow 23, and Acid Red 18) on aminated and non-aminated seed hulls of common sunflower (Helianthus annuus L.). The scope of the study included: determination of the effect of pH on dye sorption effectiveness, sorption kinetics analyses (sorption equilibrium time, pseudo-first-order/pseudo-second-order model, intramolecular diffusion model), and determination of the maximum sorption capacity against dyes (Langmuir/Freundlich isotherm). The sorbent was subjected to the FTIR analysis. The sorption capacity of the aminated sunflower seed hulls against reactive dyes RB5 and RY84 accounted for 51.02 mg/g and 63.27 mg/g, respectively, and was higher by 1665% (17.6 times higher) and 1425% (15.3 times higher) compared to that of non-modified hulls. In the case of acidic dyes, Acid Yellow 23 and Acid Red 18, the sorption capacity of the aminated sunflower seed hulls reached 44.78 mg/g and 42.19 mg/g, respectively, and was higher by 1881% (19.8 times higher) and 2284% (23.8 times higher), respectively, compared to the non-modified hulls.