bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations of The Stem-Like Properties in The Breast Cancer Cell Line MDA-MB-231 Induced by Single Pulsed Doxorubicin Treatment
Authors: Pirsko Valdis , Čakstiņa Inese , Nitiša Dina , Samoviča Marija , Daneberga Zanda , Miklaševičs Edvīns 
Published: April 2019

Abstract
Development of chemoresistance remains a significant limitation for the treatment of cancer and contributes to recurrence of the disease. Both intrinsic and acquired mechanisms of chemoresistance are characteristics of cancer stem cells (CSCs) or stem-like cells (SLCs). The aim of the study was to assess the stem-like properties in the breast cancer cell line MDA-MB-231 during and after pulsed treatment with doxorubicin (DOX) in comparison to the untreated controls.The experimental cultures were exposed to therapeutic concentration of DOX for 48 hours (treatment cultures), and subcultured to post-treatment cultures 24 hours after the removal of DOX. Stem-like properties of the cellular populations in the treatment and post--treatment cultures were assessed by the expression of the stem-cell marker genes (CD24, CD44, ITGA6, ITGB1, POU5F1, NANOG, ALDH1A1), colony-formation efficiency, growth rates, and sensitivity to DOX, 5-fluorouracil (5FU), cisplatin (CIS), and vinblastine (VBL). Exposure to DOX induced formation of giant polyploid cells that persisted in the post-treatment culture. The recovery period was characterised by a decrease in the proliferation rate, viability, and cellular adherence. The post-treatment cultures displayed decreased sensitivity to DOX and increased sensitivities to 5FU, CIS, and VBL. Cells treated with DOX displayed increased expression levels of CD24, CD44, and ALDH1A, while their expression levels at least partially normalised in the post-treatment culture. The post-treatment cultures demonstrated significantly increased colony-formation ability. During treatment with sub-lethal levels of doxorubicin and during the acute recovery period, the survival mechanisms in the breast cancer cell line MDA-MB-231 may be mediated by formation of the cellular population with stem-like properties.
Coping with Febrile Illness in Children: A Qualitative Interview Study of Parents
Authors: Urbāne Urzula Nora , Gaidule-Logina Dita , Gardovska Dace , Pavāre Jana 
Published: April 2019

Abstract
The aim of this study was to investigate parental perception of febrile illness in their children, the most commonly applied management practices, as well as the expectations from clinicians when coping with fever in children. The study included parents of patients admitted to the Emergency and Observation Department of Children’s Clinical University Hospital in Rīga, Latvia. Data were collected via semi-structured interviews. All interviews were transcribed, and the transcripts analysed by inductive thematic analysis. Thirty-four parental interviews were analysed. Six themes emerged from the study, which were: signs causing concern; beliefs regarding fever; assessment and monitoring of fever; fever management practices; help-seeking behaviour; and expectations from the healthcare personnel. Many parents believed that fever could potentially cause injuries to the nervous system, kidneys, the brain, other internal organs, and even cause death. The perceived threat of fever resulted in frequent temperature measurements and administration of antipyretics. Meeting the emotional and information needs of the parents were considered as equally important to meeting the child’s medical needs. The study found that fever phobia exists among parents. Parental misconceptions of fever lead to overly zealous management practices. Parental education initiatives must be organised in order to improve parental knowledge of fever and its management in children.
A Pilot Study on Markers of Genetic Predisposition in Tuberculous Pneumonia Patients In Latgale
Authors: Kramiča Ksenija , Eglīte Jeļena , Koļesovs Aleksandrs , Kramiča Tatjana , Titoviča Gaļina , Džeriņa Diāna , Nikolajeva Glafira , Vīksna Ludmila , Koļesova Oksana 
Published: April 2019

Abstract
Tuberculosis (TB) is still one of the top ten leading causes of death in the world. Compared to other Baltic and Eastern European countries, TB incidence (24.8 new cases per 100 000 people in 2017) in Latvia is relatively high. One of the regions with the highest TB incidence is Latgale (31.1 cases per 100 000 people). The aim of this pilot study was to identify markers of genetic predisposition to TB in Latgale. The study included 26 patients (16 males and 10 females) aged between 18 and 85 with bilateral TB pneumonia and without HIV infection. HLA typing was performed in HLA-DRB1, -DQA1, and -DQB1 loci by a polymerase chain reaction with low resolution sequence-specific primers. HLA-DRB1*07 and HLA-DRB1*11 alleles were identified as risk alleles for TB. HLA-DRB1*15 allele was a protective allele. Due to the limitations of this exploratory study, a broader study needs to be conducted to revealing specific risk and protective HLA Class II alleles for TB in the subpopulation of Latgale.
A Complete experimental study of oil/water interfacial properties in the presence of TiO2 nanoparticles and different ions
Authors: Khalilnezhad Ali , Rezvani Hosein , Ganji Parastoo , Kazemzadeh Yousef 
Published: April 2019

Previous studies on Nanoparticles (NPs) application for Enhanced Oil Recovery (EOR) methods have revealed their effective role in the rock wettability alteration, relative Interfacial Tension (IFT) and oil viscosity reduction, formation and stabilization of the emulsions, and reduced asphaltene precipitation, which are all in direct relationship with oil/water interfacial properties. This study focuses on the interfacial properties of oil/water in the presence of Titania NPs and different ions at different pressures and temperatures. For this, different concentrations of TiO2 NPs in the Formation Water (FW) were prepared to monitor the effects of NPs on the oil/water IFT, carbonate rock wettability, zeta potential, and asphaltene adsorption. The results on IFT values indicated that NPs behavior at high pressures and temperatures is completely different, as compared to the ambient conditions, and 1000 ppm NPs introduced the lowest IFT at 600 psi and 60 °C. This reduction is potentially attributed to the asphaltene adsorption at the oil/water interface by TiO2 NPs, which hinders the asphaltene deposition at the interface and in turn IFT increasing. Contact angle results revealed two distinctive behaviors for NPs at high and low concentrations. In other words, with the first interval (below the optimum concentration), an increase in NPs concentration led to a quick wettability alteration toward the water-wet condition, and with the second one (above the optimum concentration), there was an increase in contact angle with an increase in NPs concentration, which is due to the NPs stacking near the rock surface. These results were in good accordance with zeta potential measurements, in which 1000 ppm nanofluid presented the highest stability (zeta potential value of −46.9 mV). Batch adsorption experiments resulted that catalytic TiO2 NPs are capable of adsorbing asphaltene at the oil/water interface. In addition, the results on fitting experimental data to the Langmuir and Freundlich Isotherms showed that the adsorption best fitted Langmuir Isotherm and hence the adsorption type is a monolayer.
Evaluation of an uncertainty reduction methodology based on Iterative Sensitivity Analysis (ISA) applied to naturally fractured reservoirs
Authors: Costa Luís Augusto Nagasaki , Maschio Célio , Schiozer Denis José 
Published: April 2019

History matching for naturally fractured reservoirs is challenging because of the complexity of flow behavior in the fracture-matrix combination. Calibrating these models in a history-matching procedure normally requires integration with geostatistical techniques (Big Loop, where the history matching is integrated to reservoir modeling) for proper model characterization. In problems involving complex reservoir models, it is common to apply techniques such as sensitivity analysis to evaluate and identify most influential attributes to focus the efforts on what most impact the response. Conventional Sensitivity Analysis (CSA), in which a subset of attributes is fixed at a unique value, may over-reduce the search space so that it might not be properly explored. An alternative is an Iterative Sensitivity Analysis (ISA), in which CSA is applied multiple times throughout the iterations. ISA follows three main steps: (a) CSA identifies Group i of influential attributes (i = 1, 2, 3, …, n); (b) reduce uncertainty of Group i, with other attributes with fixed values; and (c) return to step (a) and repeat the process. Conducting CSA multiple times allows the identification of influential attributes hidden by the high uncertainty of the most influential attributes. In this work, we assess three methods: Method 1 – ISA, Method 2 – CSA, and Method 3 – without sensitivity analysis, i.e., varying all uncertain attributes (larger searching space). Results showed that the number of simulation runs for Method 1 dropped 24% compared to Method 3 and 12% to Method 2 to reach a similar matching quality of acceptable models. In other words, Method 1 reached a similar quality of results with fewer simulations. Therefore, ISA can perform as good as CSA demanding fewer simulations. All three methods identified the same five most influential attributes of the initial 18. Even with many uncertain attributes, only a small percentage is responsible for most of the variability of responses. Also, their identification is essential for efficient history matching. For the case presented in this work, few fracture attributes were responsible for most of the variability of the responses.
Hollow Y zeolite single crystals: synthesis, characterization and activity in the hydroisomerization of n-hexadecane
Authors: Pagis Céline , Bouchy Christophe , Dodin Mathias , Martinez Franco Raquel , Farrusseng David , Tuel Alain 
Published: April 2019

Hollow Y zeolite single crystals have been obtained from a conventional NaY zeolite following a three-step process involving a severe dealumination of the zeolite with silicon tetrachloride (step #1), followed by an acid washing under mild conditions (step #2) and finally a selective dissolution of the crystals core in the presence of protective Al species (step #3). Crystals are characterized by the presence of a regular internal cavity with 0.1–0.2 nm thick microporous walls. They contain a relatively low framework Al content but significant amounts of extraframework Al oxide species mainly located on the external surface of the crystals. Hollow crystals have been mixed with a Pt-supported alumina binder and used as catalysts in the hydroisomerization of n-hexadecane. Compared to the corresponding bulk crystals obtained after step #2, their higher activity has been attributed to a better efficiency, directly resulting from the presence of the cavity.
Örgütlerde Cam Tavan Sendromunun Örgütsel Güven Üzerine Etkisi: Lojistik Hizmet Sağlayıcılarına Yönelik Bir Araştırma
Authors: ÖRÜCÜ Edip , AKGÜL Görkem 
Published: April 2019

Kadınlar, çalışma hayatındaki sayıları gün
geçtikçe artmasına rağmen, üst düzey yönetici pozisyonlarına ulaşmalarında
çeşitli engellerle karşılaşmaktadırlar. Bu çalışmada lojistik hizmet
sağlayıcılarında çalışan kadınların cam tavan sendromunun örgütsel güven
üzerine etkisinin belirlenmesi amaçlanmaktadır. Bu bağlamda, mevcut alan yazına göre cam tavan
sendromu ve örgütsel güven kavramları açıklanmış ve aralarındaki ilişkiye yer
verilmiştir. Çalışmanın uygulama kısmında, lojistik hizmet sağlayıcılarında çalışan
kadınlara yönelik olarak anket yöntemi ile veri toplanmıştır. Yapılan analizler
sonucunda elde edilen bulgulara göre, cam tavan sendromunun örgütsel güven, yöneticiye
güven ve örgüte güven üzerinde anlamlı bir etkisi bulunmamaktadır.
CONTEMPORARY DEVELOPMENT OF QUR’ANIC EXEGESIS IN INDONESIA AND IRAN
Authors: Iqbal Muhammad , Ja'far Ja'far 
Published: April 2019

<p><strong>Abstrak: </strong>Studi ini mengkaji perkembangan terkini karya-karya tafsir di Indonesia dan Iran. Kedua negara ini memiliki perbedaan dari aspek dasar negara dan paham keagamaan penduduknya. Indonesia bukan negara Islam, berasaskan Pancasila, dan mayoritas penduduknya menganut Islam Sunni. Adapun Iran adalah sebuah Republik Islam dan mayoritas penduduknya menganut Islam Syiah. Studi ini merupakan kajian kepustakaan dan data yang diperoleh melalui telaah dokumen akan dianalisis dengan metode analisis isi. Studi ini diharapkan dapat memberikan gambaran tentang perkembangan studi tafsir di dunia Sunni dan Syiah di era kontemporer. Studi ini mengajukan temuan bahwa ulama kedua negara sama-sama mengembangkan kajian tafsir, dan telah menghasilkan sejumlah kitab tafsir. Karya tafsir di Iran bercorak Syiah, sedangkan kitab tafsir di Indonesia bercorak Sunni. Tetapi, dalam konteks kontemporer, ulama Iran telah menghasilkan banyak karya tafsir dimana para <em>marja‘ taqlid</em> memainkan peran penting dalam pengkajian tafsir, sedangkan ulama Indonesia saat ini kurang banyak menulis kitab tafsir.<br /><strong></strong></p><p><strong>Abstract</strong>: <strong>Perkembangan Kontemporer Studi Tafsir Alquran di Indonesia dan Iran</strong>. This study examines the latest developments in Qur’anic exegesis in Indonesia and Iran. These two countries differ in their forms of state and the affiliation of its people. Indonesia is not an Islamic State—albeit based on Pancasila that stresses monotheism—and the majority of its people adhere to Sunni Islam. Iran, on the other hand, is a declared Islamic Republic and the majority of its population adheres to Shiite Islam. This study is a literary review and the obtained data was analyzed using content analysis method. This study found that scholars in the two countries have developed interpretation studies, and have produced a number of Qur’anic exegesis. Naturally, Qur’anic exegesis works in Iran are Shiah in style, while those of Indonesia are Sunni in genres. Apparently, in contemporary context, Iranian scholars have been more productive than their Indonesian counterparts. <em>Marja‘ taqlid</em> plays a very important role in this scholarly enterprise.</p><p><br /><strong>Kata Kunci: </strong>Indonesia, Iran, Sunni, Syiah, Alquran, tafsir<br /><br /></p>
Coordinación de la atención entre niveles y sus factores asociados en dos subredes de la Red Municipal de Salud de la ciudad de Rosario, Argentina
Authors: Puzzolo Julia , Amarilla Delia Ines , Colautti Marisel , Moreno María Justina , De Paepe Pierre , Vargas Lorenzo Ingrid , Vazquez Navarrete Maria Luisa 
Published: April 2019

The objective was to evaluate care coordination between levels and influential factors from the experience of Primary Care (PC) and Secondary Care (SC) level doctors in subnets of the public system in the city of Rosario. Methods: Cross sectional study, based on face-to-face surveys to doctors of first and second care levels. Univariate and bivariate analysis. Results: similar in both subnets. Low information exchange, but highly valued. Adequate remission between levels, agreements among PC with SC’s recommendations. Studies are not repeated. PC doctor is responsible for the patient’s follow up; SC doctor sends patients for a follow up consultation with PC doctor, SC makes recommendations to PC and PC asks doubts to SC. A minority perceives coordinated care. Age, care level, seniority at work, care network, time/patient, coordination time in consultation, satisfaction with salary, and confidence on clinical abilities are influential factors. Conclusions: common features with particularities due to the construction of local networks.
Engineering Geological and Geotechnical Approaches for the Construction of Powerhouse Cavern of Tehri Pumped Storage Plant (1000 MW) - A Case Study
Authors: Prasad Rajeev , Sharma Nishith 
Published: April 2019

Construction of underground Cavern in the Himalayan region is full of challenges and uncertainties. Experience has shown that construction in Himalayan regions requires good understanding of geology, adequate site investigations, proper design and selection of suitable construction methodology and technology. The most commonly encountered geological problems during excavation of underground structure in Hydroelectric Projects are, Fault/Thrust/Shear Zones squeezing and swelling, wedge block failure etc. Tehri Pumped Storage Plant (PSP) is located at the left bank of river Bhagirathi in the state of Uttarakhand in Northern India. This case study indicates about the geological challenges faced and their remedial measures during the construction of Tehri PSP Powerhouse Cavern having dimension of 203m x 24m x 58m.3D-geological mapping with 1:100 scales was carried out in excavated central drift of powerhouse to evaluate the rock composition, behavior of rock mass, structural features and further investigation to finalize the layout and orientation. During the investigation Sheared Phyllite with bands of thinly Phyllite Quartzite rock were encountered in the end portion of central drift of powerhouse which had posed a mammoth challenge in designing the powerhouse cavern. Keeping in view the recommendations of geotechnical experts and the design consultants, decision were made to shift the cavern further by 50 m to avoid Sheared Phyllite bands. The shifting of cavern led to the reorientation of structures like control room, service bay and location of units etc. This paper briefly describes the Engineering Geological and Geotechnical set up of powerhouse with proper investigation approaches and excavation sequences highlighting the importance of orientation and Sheared Phyllite Zone.
SIFAT FISIK DAN KANDUNGAN GIZI BUAH ANGKAM, PEH NGAN, DAN TAPA’ KERA DI KALIMANTAN BARAT
Authors: Jemmi Jemmi , Daningsih Entin , Titin Titin 
Published: April 2019

<p>Penelitian ini bertujuan mengetahui potensi buah berdasarkan sifat fisik dan kandungan gizi. Penelitian ini terdiri dari 2 metode penelitian dengan sampel yang diperoleh menggunakan teknik <em>simple random sampling</em>. Pertama, penelitian deskriptif bertujuan mengambarkan karakteristik sifat fisik buah angkam, pehngan dan tapa’ kera meliputi bentuk, ukuran, aroma buah dll. Kedua, penelitian eksperimen bertujuan mengukur kandungan gizi buah angkam, pehngan, dantapa' kera. Analisis data kandungan gizi menggunakan ANOVA model RAL dilanjutkan uji LSD jika signifikan. Sifat fisik ketiga buah berbeda satu sama lain. Buah angkam, pehngan, tapa’ kera berpengaruh secara nyata terhadap 10 uji yaitu karbohidrat total, glukosa, fruktosa, sukrosa, lemak, air, lemak, seratkasar, vitamin C, abu.</p><p> </p><p class="Default"><strong>Kata </strong><strong>K</strong><strong>unci: </strong>Angkam, Kandungangizi, Sifat Fisik, Peh Ngan, Tapa’ Kera</p>
Tailoring selection of transforaminal interbody spacers based on biomechanical characteristics and surgical goals: evaluation of an expandable spacer
Authors: Godzik Jakub , Lehrman Jennifer N. , Newcomb Anna G. U. S. , Menon Ram Kumar , Whiting Alexander C. , Kelly Brian P. , Snyder Laura A. 
Published: April 2019

OBJECTIVETransforaminal lumbar interbody fusion (TLIF) is commonly used for lumbar fusion, such as for foraminal decompression, stabilization, and improving segmental lordosis. Although many options exist, surgical success is contingent on matching design strengths with surgical goals. The goal in the present study was to investigate the effects of an expandable interbody spacer and 2 traditional static spacer designs in terms of stability, compressive stiffness, foraminal height, and segmental lordosis.METHODSStandard nondestructive flexibility tests (7.5 N⋅m) were performed on 8 cadaveric lumbar specimens (L3–S1) to assess intervertebral stability of 3 types of TLIF spacers at L4–5 with bilateral posterior screw-rod (PSR) fixation. Stability was determined as range of motion (ROM) in flexion-extension (FE), lateral bending (LB), and axial rotation (AR). Compressive stiffness was determined with axial compressive loading (300 N). Foraminal height, disc height, and segmental lordosis were evaluated using radiographic analysis after controlled PSR compression (170 N). Four conditions were tested in random order: 1) intact, 2) expandable interbody cage with PSR fixation (EC+PSR), 3) static ovoid cage with PSR fixation (SOC+PSR), and 4) static rectangular cage with PSR fixation (SRC+PSR).RESULTSAll constructs demonstrated greater stability than the intact condition (p < 0.001). No significant differences existed among constructs in ROM (FE, AR, and LB) or compressive stiffness (p ≥ 0.66). The EC+PSR demonstrated significantly greater foraminal height at L4–5 than SRC+PSR (21.1 ± 2.6 mm vs 18.6 ± 1.7 mm, p = 0.009). EC+PSR demonstrated higher anterior disc height than SOC+PSR (14.9 ± 1.9 mm vs 13.6 ± 2.2 mm, p = 0.04) and higher posterior disc height than the intact condition (9.4 ± 1.5 mm vs 7.1 ± 1.0 mm, p = 0.002), SOC+PSR (6.5 ± 1.8 mm, p < 0.001), and SRC+PSR (7.2 ± 1.2 mm, p < 0.001). There were no significant differences in segmental lordosis among SOC+PSR (10.1° ± 2.2°), EC+PSR (8.1° ± 0.5°), and SRC+PSR (11.1° ± 3.0°) (p ≥ 0.06).CONCLUSIONSAn expandable interbody spacer provided stability, stiffness, and segmental lordosis comparable to those of traditional nonexpandable spacers of different shapes, with increased foraminal height and greater disc height. These results may help inform decisions about which interbody implants will best achieve surgical goals.
Peningkatan Kemampuan Guru dalam Memanfaatkan Lingkungan Sekolah Sebagai Sumber Belajar Melalui Supervisi Akademik di SMK Sabilal Muhtadin Balikpapan
Authors: Suharlena Suharlena 
Published: April 2019

AbstractThe research is designed in the form of action research school with two cycles, with each cycle was carried out in two three meetings. The subjects of this study were teachers at SMK Sabilal Muhtadin Balikpapan consisting of eight teachers with different subjects. In the first cycle the average value obtained from the attitude of the teachers discuss through academic supervision is 79.38 category “enough”, while the second cycle of the average value obtained was 84.88, the category “good”, the average value of the obtained from the assessment of learning scenarios in the first cycle is 78.75, the category of “ enough”, while the second cycle of the average value obtained was 82.08, the category “good” , Seeing the average value obtained from the analysis, we can conclude that from the first cycle to the second cycle, an increase in value the average obtained from each of the components that are observed and assessed, which means coaching and guidance through academic supervision can improve the ability of teachers to utilize the school environment as a learning resource. Keywords : the ability of teachers , academic supervision Abstrak Penelitian ini dirancang dalam bentuk Penelitian Tindakan Sekolah yang dilaksanakan dalam dua siklus, dimana setiap siklusnya dilaksanakan dalam dua sampai tiga kali pertemuan. Adapun subyek penelitian ini adalah guru-guru di SMK Sabilal Muhtadin Balikpapan yang terdiri dari delapan orang guru dengan mata pelajaran berbeda-beda. Pada siklus I nilai rata-rata yang diperoleh dari sikap guru berdiskusi melalui supervise akademik adalah 79,38 kategori “cukup”,sedangkan pada siklus II nilai rata-rata yang diperoleh adalah 84,88, kategori “baik”, nilai rata-rata yang diperoleh dari penilaian scenario pembelajaran pada siklus I yaitu 78,75,kategori “cukup”, sedangkan pada siklus II nilai rata-rata yang diperoleh adalah 82,50, nilai rata-rata yang diperoleh dari penilaian pelaksanaan pembelajaran pada siklus I yaitu 78,33, kategori “cukup” ,sedangkan pada siklus II nilai rata-rata yang diperoleh adalah 82,08 , kategori “baik”.Melihat nilai rata-rata yang diperoleh dari hasil analisis tersebut dapat disimpulkan bahwa dari siklus I ke siklus II, terjadi peningkatan nilai rata-rata yang diperoleh dari masing-masing komponen yang diobservasi maupun yang dinilai,yang berarti pembinaan dan bimbingan melalui supervise akademik dapat meningkatkan kemampuan guru dalam memanfaatkan lingkungan sekolah sebagai sumber belajar. Kata kunci : kemampuan guru, supervisi akademik