bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unique solution for a new system of fractional differential equations
Authors: Zhai Chengbo , Zhu Xiaolin 
Published: September 2019

Abstract
In this article, we discuss a new system of fractional differential equations
$$ \textstyle\begin{cases} D_{0^{+}}^{s_{1}} u(t) + f(t,u(t),v(t))=z_{1}(t), \quad 0< t< 1, \\ D_{0^{+}}^{s_{2}} v(t) + g(t,u(t),v(t))=z_{2}(t), \quad 0< t< 1, \\ u(0)=u(1)=u^{\prime }(0)=u^{\prime }(1)=0, \qquad D_{0^{+}}^{\beta _{1}} u(0)=0, \qquad D_{0^{+}}^{\beta _{1}} u(1)= b_{1} D_{0^{+}}^{\beta _{1}} u(\eta _{1}), \\ v(0)=v(1)=v^{\prime }(0)=v^{\prime }(1)=0, \qquad D_{0^{+}}^{\beta _{2}} v(0)=0, \qquad D_{0^{+}}^{\beta _{2}} v(1)= b_{2} D_{0^{+}}^{\beta _{2}} v(\eta _{2}), \end{cases} $$

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. We establish the existence and uniqueness of solutions for the problem by a recent fixed point theorem of increasing Ψ-$(h,e)$
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-concave operators defined on ordered sets. Furthermore, the results obtained are well proven by means of a specific example.
Specific gut microbiome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantation
Authors: Ingham Anna Cäcilia , Kielsen Katrine , Cilieborg Malene Skovsted , Lund Ole , Holmes Susan , Aarestrup Frank M. , Müller Klaus Gottlob , Pamp Sünje Johanna 
Published: September 2019

AbstractBackgroundIncreasing evidence reveals the importance of the microbiome in health and disease and inseparable host-microbial dependencies. Host-microbe interactions are highly relevant in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT), i.e., a replacement of the cellular components of the patients’ immune system with that of a foreign donor. HSCT is employed as curative immunotherapy for a number of non-malignant and malignant hematologic conditions, including cancers such as acute lymphoblastic leukemia. The procedure can be accompanied by severe side effects such as infections, acute graft-versus-host disease (aGvHD), and death. Here, we performed a longitudinal analysis of immunological markers, immune reconstitution and gut microbiota composition in relation to clinical outcomes in children undergoing HSCT. Such an analysis could reveal biomarkers, e.g., at the time point prior to HSCT, that in the future could be used to predict which patients are of high risk in relation to side effects and clinical outcomes and guide treatment strategies accordingly.ResultsIn two multivariate analyses (sparse partial least squares regression and canonical correspondence analysis), we identified three consistent clusters: (1) high concentrations of the antimicrobial peptide human beta-defensin 2 (hBD2) prior to the transplantation in patients with high abundances ofLactobacillaceae, who later developed moderate or severe aGvHD and exhibited high mortality. (2) Rapid reconstitution of NK and B cells in patients with high abundances of obligate anaerobes such asRuminococcaceae, who developed no or mild aGvHD and exhibited low mortality. (3) High inflammation, indicated by high levels of C-reactive protein, in patients with high abundances of facultative anaerobic bacteria such asEnterobacteriaceae.Furthermore, we observed that antibiotic treatment influenced the bacterial community state.ConclusionsWe identify multivariate associations between specific microbial taxa, host immune markers, immune cell reconstitution, and clinical outcomes in relation to HSCT. Our findings encourage further investigations into establishing longitudinal surveillance of the intestinal microbiome and relevant immune markers, such as hBD2, in HSCT patients. Profiling of the microbiome may prove useful as a prognostic tool that could help identify patients at risk of poor immune reconstitution and adverse outcomes, such as aGvHD and death, upon HSCT, providing actionable information in guiding precision medicine.
RETRACTED ARTICLE: lncRNA TUG1 modulates proliferation, apoptosis, invasion, and angiogenesis via targeting miR-29b in trophoblast cells
Authors: Li Qian , Zhang Jing , Su Dong-Mei , Guan Li-Na , Mu Wei-Hong , Yu Mei , Ma Xu , Yang Rong-Juan 
Published: September 2019

Abstract
Background
Pre-eclampsia (PE) is regarded as the leading cause of maternal and neonatal morbidity and mortality. Nevertheless, the potential mechanism for the regulation of trophoblast behaviors and the pathogenesis of PE remain largely elusive. Recently, accumulating evidence emphasized that aberrant expression of long non-coding RNAs (lncRNAs) functions as imperative regulators in human diseases, including PE. Thus, identifying PE-related specific lncRNAs to uncover the underlying molecular mechanism is of much significance. However, the functional roles and underlying mechanisms of lncRNAs in PE progression remain unclear.

Method
Placenta tissues obtained from patients with PE and healthy pregnant women were performed to measure TUG1 expression by qRT-PCR analysis. Transient transfections were conducted to alter TUG1 expression. Cell Counting Kit-8 (CCK-8) and flow cytometry assays were carried out to assess cell proliferation and apoptosis, respectively. Transwell and tube formation assays were performed to measure the capacity of cell invasion and angiogenesis. Moreover, the luciferase reporter assay was subjected to verify the binding relationship between TUG1 and miR-29b. Western blot analysis was performed to detect the expression of key proteins in the PI3K/AKT and ERK pathway.

Results
Here, we identified a lncRNA, TUG1, which was notably decreased in placental samples of PE patients. Functional experiments of loss- or gain-of-function assays also verified that ectopic expression of TUG1 promoted cell proliferation, invasion, and angiogenesis, but negatively regulated cell apoptosis, whereas TUG1 inhibition presented the opposite effects. Furthermore, mechanistic researches revealed that TUG1 could act as a molecular sponge for miR-29b, thus regulating MCL1, VEGFA, and MMP2 to modulate PE development.

Conclusions
Taken together, our findings demonstrated that TUG1 exerts as a critical role in PE progression, which might furnish a novel therapeutic marker for PE treatment.
A proper reference metabolic equivalent value to assess physical activity intensity in Japanese female nurses
Authors: Ideno Yuki , Hayashi Kunihiko , Lee Jung Su , Miyazaki Yukiko , Suzuki Shosuke 
Published: September 2019

Abstract

Background
Various questionnaires have been developed to assess physical activity, but only a few simple questionnaires are suitable for self-administration in large groups of midlife working women. This study examined the usefulness of the Japan Nurses’ Health Study (JNHS) questionnaire for self-administered physical activity surveys.

Methods
The JNHS physical activity questionnaire consisted of items covering seven degrees of intensity. The metabolic equivalents (METs) for the physical activity intensity of the questionnaire were estimated from energy expenditure as measured by a uniaxial accelerometer with the Markov Chain Monte Carlo (MCMC) simulation. The estimated METs were then assigned to the JNHS baseline survey data, and the total energy expenditure (TEE) and the time spent performing ≥3 METs hour of physical activity, called moderate to vigorous intensity physical activity (MVPA), were calculated.

Results
For working situations, application of the MCMC simulation resulted in estimated reference values of 1.2 METs for “sitting work”, 1.6 METs for “standing work”, 1.8 METs for “walking work”, and 4.5 METs for “heavy work”. For non-working situations, the estimated values were 1.1 METs for sedentary time, 2.4 METs for “moderate physical activity”, 4.4 METs for “vigorous physical activity”, and 9.4 METs for “very vigorous physical activity”. When these estimated METs were used, the mean TEE/day was 1808 kcal. This corresponded to − 3.0% of the TEE/day generated by the accelerometer. These estimated MET values showed similar results as a previous study measuring activity using the doubly-labeled water method. The number of hours per week of MVPA significantly decreased with age, which is also consistent with previous findings.

Conclusions
Estimated reference MET values in this study were similar to those in previous studies of Japanese women. The JNHS questionnaire is therefore useful for epidemiological surveys of midlife working women because it assigns estimated MET values as physical activity intensities.
A rare case of metastatic solitary fibrous tumor of the pancreas manifesting as a cystic neoplasm: a case report
Authors: Yamashita Hironori , Fujino Yasuhiro , Ohara Tadayuki , Kakinoki Keitaro , Sugimoto Takemi , Kajimoto Kazuyoshi , Tominaga Masahiro 
Published: September 2019

Abstract

Background
Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that typically arises from the pleura. Although it may appear in other organs, it rarely develops in the pancreas. We report herein a rare case of metastatic SFT of the pancreas originating from an intracranial tumor and subsequently identified as a cystic neoplasm of the pancreas.

Case presentation
A 58-year-old woman with a past medical history of brain tumor visited the hospital for further investigation of a cystic tumor in the pancreas tail. Abdominal imaging showed a heterogeneously enhancing mass that was initially suspected as a neuroendocrine neoplasm, solid pseudopapillary neoplasm, or mucinous cystic neoplasm of the pancreas. Distal pancreatectomy was performed without any intraoperative and postoperative complications. Pathological findings confirmed a diagnosis of malignant SFT of the pancreas with hyperproliferative potential. A histopathological review of her brain tumor revealed that the pancreatic tumor was derived from her brain lesion. The patient developed recurrent brain disease 4 years after the pancreatectomy, but no recurrence has been observed in the abdominal cavity.

Conclusions
SFT should be considered in the differential diagnosis of untypical hypervascular pancreatic mass, particularly in patients with a history of an intrathoracic or intracranial mesenchymal tumor. Immunohistochemical analysis is crucial in detecting this tumor entity. Hyperproliferative status indicates a malignant disease and requires careful postoperative observation.
Welfare effects of technology-based climate policies in liberalized electricity markets: seeing beyond total system cost
Authors: Maire Sophie , Thalmann Philippe , Vöhringer Frank 
Published: September 2019

Abstract
This paper is a contribution to assessing the Swiss energy transition, with an emphasis on the consequences of decommissioning the nuclear power plants for the electricity market and the whole economy. We expect that increased renewable generation and demand-side policies of the type already envisioned will not suffice to close the supply gap, so that Switzerland will have to rely on more imports of electricity, moving away from the export surpluses realized almost every year since 1910. As this reference scenario is contrary to desired energy security, a policy scenario is proposed in which net electricity trade is constrained to balance over the year and the supply gap is closed by relaxing the existing restrictions on gas-fired power plants. One constraint replaces another one, so that the impacts are not obvious. Furthermore, the prices of electricity and natural gas evolve quite differently through time and depend on climate and energy policy. We use a modeling framework coupling a detailed representation of electricity generation and an encompassing representation of the macro-economy to compare these scenarios in terms of both total system cost and welfare. Both indicators favor the reference scenario without gas-fired power plants in spite of its higher marginal costs for electricity. The welfare loss of the policy scenario is small, though, much smaller than the increase in total system cost. This shows that a coupled bottom-up top-down modeling framework assessing the welfare effect of policies can yield very different results from those of an energy system model assessing their impact on total system cost.
Assessment of the optic nerve and its arterial supply by ultrasound imaging in multiple sclerosis patients
Authors: Al Kattan Manal Mahmoud , Labib Amira Ahmed , Ismail Rania Shehata , Aboul fotouh Alshaimaa M. , Mohammed Emad El Din Mostafa 
Published: September 2019

Abstract

Background
Transorbital sonography (TOS) has emerged as a promising assessment tool of the optic nerve and orbital arterial supply in multiple sclerosis (MS) patients.

Objective
To evaluate optic nerve diameter (OND), optic nerve sheath diameter (ONSD), and orbital hemodynamics using TOS in MS patients.

Methods
Forty MS patients and 28 matched healthy controls were included. Thirty-three eyes with previous optic neuritis (ON) and 47 eyes without previous ON of MS patients were examined. All subjects were submitted to assessment of OND, ONSD, and parameters of orbital hemodynamics using orbital ultrasound.

Results
OND and ONSD were smaller in MS eyes with previous ON than in controls. MS eyes with and without previous ON had statistically significant higher peak systolic and mean velocity of posterior ciliary arteries than the control eyes. Orbital blood flow velocities were negatively correlated with the duration of disease and Expanded Disability Status Scale (EDSS). A statistically significant decrease in blood flow velocities of the central retinal artery was detected in secondary progressive MS (SPMS) patients than in relapsing-remitting MS patients (RRMS).

Conclusion
TOS can be used as a feasible tool to detect optic atrophy in MS patients. MS patients may have abnormal retrobulbar hemodynamics compared to healthy controls.
Association Between Power Morcellation and Mortality in Women With Unexpected Uterine Cancer Undergoing Hysterectomy or Myomectomy
Authors: Xu Xiao , Lin Haiqun , Wright Jason D. , Gross Cary P. , Boscoe Francis P. , Hutchison Lindsey M. , Schwartz Peter E. , Desai Vrunda B. 
Published: September 2019

PURPOSE Despite concerns that power morcellation may adversely affect prognosis of patients with occult uterine cancer, empirical evidence has been limited and inconclusive. In this study, we aimed to determine whether uncontained power morcellation at the time of hysterectomy or myomectomy is associated with increased mortality risk in women with occult uterine cancer. METHODS By linking statewide hospital discharge records with cancer registry data in New York, we identified 843 women with occult endometrial carcinoma and 334 women with occult uterine sarcoma who underwent a hysterectomy or myomectomy for presumed benign indications during the period October 1, 2003, through December 31, 2013. Within this cohort, we compared disease-specific and all-cause mortality of women who underwent laparoscopic supracervical hysterectomy/laparoscopic myomectomy (LSH/LM), a surrogate indicator for uncontained power morcellation, with women who underwent supracervical abdominal hysterectomy and total abdominal hysterectomy (TAH), which did not involve power morcellation. Multivariable Cox regressions and propensity score method were used to adjust for patient characteristics. RESULTS Among women with occult uterine sarcoma, LSH/LM was associated with a higher risk for disease-specific mortality than TAH (adjusted hazard ratio [aHR], 2.66, 95% CI, 1.11 to 6.37; adjusted difference in 5-year disease-specific survival, −19.4%, 95% CI, −35.8% to −3.1%). In the subset of women with leiomyosarcoma, LSH/LM was associated with an increased risk for disease-specific mortality compared with supracervical abdominal hysterectomy (aHR, 3.64, 95% CI, 1.50 to 8.86; adjusted difference in 5-year disease-specific survival, −31.2%, 95% CI, −50.0% to −12.3%) and TAH (aHR, 4.66, 95% CI, 1.97 to 11.00; adjusted difference in 5-year disease-specific survival, −37.3%, 95% CI, −54.2% to −20.3%). Among women with occult endometrial carcinoma, there was no significant association between surgical approach and disease-specific mortality. CONCLUSION Uncontained power morcellation was associated with higher mortality risk in women with occult uterine sarcoma, especially in those with occult leiomyosarcoma.
The lncRNA hsrω regulates arginine dimethylation of human FUS to cause its proteasomal degradation in Drosophila
Authors: Lo Piccolo Luca , Mochizuki Hideki , Nagai Yoshitaka 
Published: September 2019

ABSTRACT
Long non-coding RNAs (lncRNAs) have structural and regulatory effects on RNA-binding proteins (RBPs). However, the mechanisms by which lncRNAs regulate the neurodegenerative-causative RBP like FUS protein remain poorly understood. Here, we show that knockdown of the Drosophila lncRNA hsrω causes a shift in the methylation status of human FUS from mono- (MMA) to di-methylated (DMA) arginine via upregulation of the arginine methyltransferase 5 (PRMT5, known as ART5 in flies). We found this novel regulatory role to be critical for FUS toxicity since the PRMT5-dependent dimethylation of FUS is required for its proteasomal degradation and causes a reduction of high levels of FUS. Moreover, we show that an increase of FUS causes a decline of both PRMT1 (known as ART1 in flies) and PRMT5 transcripts, leading to an accumulation of neurotoxic MMA-FUS. Therefore, overexpression of either PRMT1 or PRMT5 is able to rescue the FUS toxicity. These results highlight a novel role of lncRNAs in post-translation modification (PTM) of FUS and suggest a causal relationship between lncRNAs and dysfunctional PRMTs in the pathogenesis of FUSopathies.
Analysis and characterization of extra virgin olive oils
Authors: Checchetti Andrea , Martano Donato , Veltri Rosagnela 
Published: September 2019

Samples of extra virgin olive oils obtained from the olive trees of the territory of San Giovanni in Fiore (CS), Italy, and samples common brands of extra virgin olive oils sold on the national territory, have been analysed according to EU regulation n. 61/2011 of the Commission of 24 January 2011. The extra virgin oils examined were characterized by investigating their acidity, the number of peroxides, the rancidity, and the spectrophotometric parameters that provide useful elements for assessing the composition and the quality. Furthermore, the infrared analysis provides useful data that help carry out quality control.
Χρήση και Ασφάλεια Διαδικτύου
Authors: Πετράκη Ευθυμία , Παπαϊωάννου Βασιλική , Μουρατίδου Βασιλική 
Published: September 2019

Στην παρούσα εργασία μελετήθηκε η χρήση του διαδικτύου στους μαθητές της Α, Β, Γ Γυμνασίου σε κεντρικό Γυμνάσιο της πόλης του Αγρινίου. Διανεμήθηκε ερωτηματολόγιο κλειστού τύπου και τα ερευνητικά ερωτήματα αφορούσαν την ασφάλεια στα κοινωνικά δίκτυα, τις ώρες ενασχόλησης των εφήβων στο διαδίκτυο, την χρήση των μέσων κοινωνικής δικτύωσης, τον εκφοβισμό μέσου διαδικτύου, τον τρόπο πρόσβασής τους, την ηλικία έναρξης χρήσης του διαδικτύου και τις δραστηριότητές τους. Η μέθοδος της έρευνας είναι η εμπειρική .Διανεμήθηκε ερωτηματολόγιο κλειστού τύπου από το Δεκέμβριο του 2016 μέχρι τον Ιανουάριο 2017.Τα αποτελέσματα της έρευνας αναλύθηκαν με απώτερο σκοπό να προταθούν λύσεις αντιμετώπισης προς ολόκληρη τη μαθητική κοινότητα.
Μελέτη της μεταβολής της περιεκτικότητας σε βιταμίνη C φυσικού χυμού πορτοκαλιού σε συνάρτηση με το χρόνο
Authors: Μανώλη Γεωργία , Κώτσια Λήδα-Βαΐα-Ζιζέλ , Μαυροειδής Δημήτριος , Μπαρλαμπά Μαρία Ελένη , Ουλή Μαρία Φωτεινή , Πετροπούλου Φωτεινή Μαρκέλλα , Τζουρμανά Ελευθερία , Χατζηγιάννη Αλεξάνδρα 
Published: September 2019

Στην εργασία αυτή μελετήθηκε η μεταβολή της περιεκτικότητας του φυσικού χυμού πορτοκαλιού σε βιταμίνη C (ασκορβικό οξύ) ως συνάρτηση του χρόνου σε θερμοκρασία περιβάλλοντος για δύο διαφορετικά είδη χυμού: α) φυσικό χυμό πορτοκαλιού από πορτοκάλια που στύψαμε και β) από φυσικό χυμό του εμπορίου . Ο προσδιορισμός της περιεκτικότητας του πορτοκαλιού σε ασκορβικό οξύ έγινε με οξειδοαναγωγική ογκομέτρηση. Χρησιμοποιήσαμε διάλυμα KIO3/KI σε όξινο περιβάλλον και το τέλος της ογκομέτρησης ανιχνεύθηκε με την αλλαγή χρώματος λόγω προσθήκης διαλύματος αμύλου. Το Ι2 που παράγεται κατά την αντίδραση οξινισμένου με HCl διαλύματος KIO3, με διάλυμα KI , οξειδώνει το ασκορβικό οξύ σε δεϋδροασκορβικό οξύ. Όταν όλη η ποσότητα του ασκορβικού οξέος οξειδωθεί, τότε η περίσσεια του Ι2 που παράγεται από τη πρώτη αντίδραση, αντιδρά με τα ανιόντα Ι- που υπάρχουν ήδη στο διάλυμα και σχηματίζει σύμπλοκο με το άμυλο που έχουμε ήδη προσθέσει στο διάλυμα που ογκομετρούμε. Το σύμπλοκο αυτό έχει χαρακτηριστικό βαθύ μπλέ χρώμα. Τα αποτελέσματα της εργασίας αυτής έδειξαν ότι δεν μπορούμε να διατηρήσουμε έναν φρεσκοστυμμένο χυμό πορτοκαλιού ή έναν φυσικό χυμό πορτοκαλιού του εμπορίου σε θερμοκρασία περιβάλλοντος για κάποιο χρονικό διάστημα χωρίς να μειωθεί η περιεκτικότητά του σε βιταμίνη C. Η ελάττωση της περιεκτικότητας σε Βιταμίνη C για τα δύο είδη χυμού ήταν 62% και 66.7% αντίστοιχα μετά από χρόνο μίας εβδομάδας.