bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase Transformation Behavior of a Two‐Dimensional Zeolite
Authors: Bae Juna , Cichocka Magdalena O. , Zhang Yi , Bacsik Zoltán , Bals Sara , Zou Xiaodong , Willhammar Tom , Hong Suk Bong 
Published: May 2019

AbstractUnderstanding the molecular‐level mechanisms of phase transformation in solids is of fundamental interest for functional materials such as zeolites. Two‐dimensional (2D) zeolites, when used as shape‐selective catalysts, can offer improved access to the catalytically active sites and a shortened diffusion length in comparison with their 3D analogues. However, few materials are known to maintain both their intralayer microporosity and structure during calcination for organic structure‐directing agent (SDA) removal. Herein we report that PST‐9, a new 2D zeolite which has been synthesized via the multiple inorganic cation approach and fulfills the requirements for true layered zeolites, can be transformed into the small‐pore zeolite EU‐12 under its crystallization conditions through the single‐layer folding process, but not through the traditional dissolution/recrystallization route. We also show that zeolite crystal growth pathway can differ according to the type of organic SDAs employed.
Self‐Sorting Double‐Network Hydrogels with Tunable Supramolecular Handedness and Mechanical Properties
Authors: Liu Guofeng , Zhou Cheng , Teo Wei Liang , Qian Cheng , Zhao Yanli 
Published: May 2019

AbstractSelf‐sorting, simultaneous, and orthogonal operations during the self‐assembly of complex mixtures are commonly observed for biological species but rare in artificial systems. In this study, we designed two gelators (LPF and LPFEG) containing the same chiral phenylalanine core but different achiral peripheral substituents to give hydrogels with opposite supramolecular handedness. When the two hydrogels were mixed, double‐network nanofibers with opposite handedness were formed by spontaneous high‐order organization and self‐sorting of the two gelators. The chiroptical activity of the double‐network hydrogels could be tuned by varying the molar ratio of LPF and LPFEG in the mixture, thus showing that the two gelators were highly independent of each other. Enhanced mechanical properties were observed for the interpenetrating networks when the LPF/LPFEG molar ratio was 3:7, with a more than fourfold increase in both the storage (G′) and loss modulus (G′′) relative to those of the individual hydrogels.
CO2Fixation and Catalytic Reduction by a Neutral Aluminum Double Bond
Authors: Weetman Catherine , Bag Prasenjit , Szilvási Tibor , Jandl Christian , Inoue Shigeyoshi 
Published: May 2019

AbstractCO2fixation and reduction to value‐added products is of utmost importance in the battle against rising CO2levels in the Earth's atmosphere. An organoaluminum complex containing a formal aluminum double bond (dialumene), and thus an alkene equivalent, was used for the fixation and reduction of CO2. The CO2fixation complex undergoes further reactivity in either the absence or presence of additional CO2, resulting in the first dialuminum carbonyl and carbonate complexes, respectively. Dialumene (1) can also be used in the catalytic reduction of CO2, providing selective formation of a formic acid equivalent via the dialuminum carbonate complex rather than a conventional aluminum–hydride‐based cycle. Not only are the CO2reduction products of interest for C1added value products, but the organoaluminum complexes isolated represent a significant step forward in the isolation of reactive intermediates proposed in many industrially relevant catalytic processes.
Modified polyacrylamide containing phenylsulfonamide and betaine sulfonate with excellent viscoelasticity for EOR
Authors: Zhang Huichao , Gou Shaohua , Zhou Lihua , Fei Yumei , Peng Chuan , Huang Jinglun , Chen Long 
Published: May 2019

ABSTRACTThe monomers containing phenylsulfonamide N‐allyl‐4‐methylbenzenesulfonamide (TCAP) and N,N‐diallyl‐4‐methyl benzenesulfonamide (TCDAP) were copolymerized with acrylamide (AM), acrylic acid (AA), and 3‐(3‐methacrylamidopropyl‐dimethylammonio)‐propane‐1‐sulfonate (MDPS), respectively, through free‐radical micellar copolymerization in deionized water for enhanced oil recovery (EOR). Then, the effect of the synthesis conditions was investigated simultaneously; the copolymers were characterized by Fourier transform infraredFTIR, nuclear magnetic resonance, scanning electron microscopy, and thermogravimetric analysis. It was found that the thickening function, high‐temperature resistance (120 °C), and anti‐shear ability were improved significantly. It was also found that the copolymers had excellent viscoelasticity at the lower shear frequencies. When the copolymers were dissolved in 10,000 mg L−1 NaCl, 2000 mg L−1 CaCl2, and 2000 mg L−1 MgCl2 solutions, the viscosity retention rates of AM/AA/TCAP/MDPS and AM/AA/TCDAP/MDPS were 13.3, 11.1, 10.6% and 18.6, 15.2, 11.7%, respectively. In addition, the copolymers for EOR at 60 °C were 11.4 and 13.8%, respectively, which demonstrated that the copolymers possessed excellent performance for potential application in EOR. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47971.
Reusable ionic liquid‐functionalized polystyrene for the highly efficient removal of sulfadiazine sodium
Authors: Cheng Meng , Song Gangfu , Zhu Guifen , Shi Dongyang , Fan Jing 
Published: May 2019

ABSTRACTThe extensive use of sulfonamides has caused serious ecotoxicological effects, sulfonamide antibiotics are difficult to remove when they are in their anionic form. In this work, a novel polystyrene supported ionic liquid (PS‐CH2‐[TSiIm][Cl]) material was prepared for the effective removal of sulfadiazine sodium (SDS). Results showed that the adsorption efficiency maintained relatively stable and high in a wide pH (6–10) and temperature (25–70 °C) ranges. SDS adsorbed onto the PS‐CH2‐[TSiIm][Cl] could be well evaluated by Langmuir model and the maximum adsorption capacity could be reached as high as 438.2 mg g−1. Simultaneously, the PS‐CH2‐[TSiIm][Cl] exhibited excellent removal performance toward trace SDS at ppb level (0.005 mg L−1). Common inorganic ions such as K+, Na+, Ca2+, and Cl−had no effect of on the removal of SDS even if their concentrations were 20 000 times higher than that of SDS. And the PS‐CH2‐[TSiIm][Cl] was easy to regenerate without loss in adsorption performance. Additionally, the PS‐CH2‐[TSiIm][Cl] was applied to remove the SDS from environmental water samples. The possible adsorption mechanism was also investigated. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019,136, 47981.
Identification of new NIK inhibitors by discriminatory analysis‐based molecular docking and biological evaluation
Authors: Cheng Gang , Mei Xiao‐Bing , Yan You‐You , Chen Jing , Zhang Bo , Li Jia , Dong Xiao‐Wu , Lin Neng‐Ming , Zhou Yu‐Bo 
Published: May 2019

AbstractNF‐κB inducing kinase (NIK) is a key regulator in the noncanonical nuclear factor κB cells (NF‐κB) signaling pathway. Dysregulation of NIK is often related with autoimmune disorders and malignancies. However, the number of reported NIK inhibitors is scarce. Discriminatory analysis‐based molecular docking was used to examine the accuracy of the binding conformation and to estimate the binding affinity, leading to the identiﬁcation of several new NIK inhibitors with moderate IC50 (ranging from 48.9 to 103.4 μM). Among them, compound 5, the most potent one (IC50 48.9 ± 6.9 μM), also showed moderate antiproliferation activity against cancer SW1990 cells, with an IC50 value of 20.1 ± 6.0 μM. Further dynamic simulations were performed to provide more in‐depth details on the binding conformation of compound 5 and the NIK protein, providing some structural clues for further optimization of compound 5 as a novel NIK inhibitor.
The effects of an integrated supportive care intervention on quality of life outcomes in outpatients with breast and gynecologic cancer undergoing chemotherapy: Results from a randomized controlled trial
Authors: Klafke Nadja , Mahler Cornelia , von Hagens Cornelia , Uhlmann Lorenz , Bentner Martina , Schneeweiss Andreas , Mueller Andreas , Szecsenyi Joachim , Joos Stefanie 
Published: May 2019

AbstractThe aim of the Complementary Nursing in Gynecologic Oncology study was to investigate the effects of a complex, nurse‐led, supportive care intervention using Complementary and Integrative Medicine (CIM) on patients’ quality of life (QoL) and associated patient‐reported outcomes. In this prospective, pragmatic, bicentric, randomized controlled trial, women with breast or gynecologic cancer undergoing a new regimen of chemotherapy (CHT) were randomly assigned to routine supportive care plus intervention (intervention group, IG) or routine care alone (control group, CG). The intervention consisted of CIM applications and counseling for symptom management, as well as CIM information material. The primary endpoint was global QoL measured with the EORTC‐QLQ‐C30 before and after CHT. Mixed linear models considering fixed and random factors were used to analyze the data. In total, 126 patients were randomly assigned into the IG and 125 patients into the CG (median age 51 years). The patients’ medical and socio‐demographic characteristics were homogenous at baseline and at follow‐up. No group effects on QoL were found upon completion of CHT (estimate −1.04 [−4.89; 2.81]; P = 0.596), but there was a significant group difference in favor of the IG 6 months later (estimate 6.643 [1.65; 11.64]; P = 0.010). IG patients did also experience significant better emotional functioning (P = 0.007) and less fatigue (P = 0.027). The tested supportive intervention did not improve patients’ QoL outcomes directly after CHT (T3), but was associated with significant QoL improvements when considering the change from baseline to the time point T4, which could be assessed 6 months after patients’ completion of CHT. This delayed effect may have resulted due to a strengthening of patients’ self‐management competencies.
Lelio Orci, the modern master of morphology
Authors: Ribatti Domenico 
Published: May 2019

AbstractLelio Orci has made seminal contributions to our understanding of pancreatic islet structure and function. He introduced quantitative criteria to structural analysis in the study of endocrine pancreas in a series of works performed in collaboration with Albert Renold, Roger Unger, and Donald Steiner. Orci has moved islet cell morphology from the primitive era of histochemistry and electron microscopy into the modern era of cell biology, applying the most advanced techniques and covering every aspect of normal and pathological structure–function relationships. In collaboration with James Rothman in New York and Randy Schekman in Berkley, Orci discovered that the transport steps from the endoplasmic reticulum to the Golgi complex, and within the Golgi, are mediated by two sets of vesicles coated with protein envelopes different from clathrin.
miR‐145 inhibits glutamine metabolism through c‐myc/GLS1 pathways in ovarian cancer cells
Authors: Li Jie , Li Xu , Wu Lei , Pei Meili , Li Huijin , Jiang Yu 
Published: May 2019

AbstractmiR‐145 has been found to be a participant in cancer metastasis and glucose metabolism in ovarian cancer. However, the role of glutamine metabolism in ovarian cancer remains unclear. In this study, we aim to elucidate the molecular mechanism underlying the regulation of glutamine metabolism by miR‐145 in ovarian cancer cells. The messenger RNA (mRNA) levels of miR‐145 and glutaminase 1 (GLS1) were examined by quantitative real‐time polymerase chain reaction (qRT‐PCR). The protein levels of c‐myc and GLS1 were detected by western blot analysis. Luciferase reporter assays were used to validate c‐myc was a target of miR‐145. Glutamine metabolism was analyzed using assay kits. In addition, we performed luciferase reporter assays and chromatin immunoprecipitation assay to validate c‐myc transcription activated GLS1 and promoted GLS1 expression. The qRT‐PCR demonstrated that the mRNA level of miR‐145 and GLS1 was negatively correlated in ovarian cancer tissues and cell lines. Kaplan–Meier survival analysis and the log‐rank test showed that patients with high miR‐145 expression had significantly increased the overall survival. The overexpression of miR‐145 inhibited glutamine consumption, α‐ketoglutarate production, and cellular ATP levels. Furthermore, we found miR‐145 inhibited glutamine metabolism by targeting c‐myc. Moreover, c‐myc could promote GLS1 expression by transcription activated. Together, our results revealed that miR‐145 inhibited glutamine metabolism through c‐myc/GLS1 pathways in ovarian cancer cells, which may improve the current strategy of ovarian cancer diagnosis and therapy.
Impact of intravascular ultrasound‐guided drug‐eluting stent implantation on patients with chronic kidney disease: Results from ULTIMATE trial
Authors: Zhang Junjie , Gao Xiaofei , Ge Zhen , Han Leng , Lu Shu , Qian Xuesong , Li Qihua , Lu Qinghua , Chen Chonghao , Chen Shao‐Liang ,   ULTIMATE Investigators
Published: May 2019

AbstractObjectivesThis study aimed to investigate the impacts of intravascular ultrasound (IVUS)‐guided drug‐eluting stent (DES) implantation on patients with chronic kidney disease (CKD) based on the ULTIMATE trial.BackgroundIVUS‐guided DES implantation improves clinical outcomes in complex lesions. However, routine IVUS guidance in patients with CKD remains controversial.MethodsCKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL min−1 1.73 m−2. The primary end point was target vessel failure (TVF) at 12 months, including cardiac death, target vessel myocardial infarction, and clinically driven target vessel revascularization.ResultseGFR was available in 1,443 patients, of whom 723 were in the IVUS guidance group, and 720 were in the angiography guidance group. Finally, CKD was present in 349 (24.2%) patients. At 12 months, TVF in the CKD group was 7.2%, which was significantly higher than 3.2% in the non‐CKD group (p = .001). Moreover, there were 25 TVFs in the CKD patients, with 7 (3.9%) TVFs in the IVUS group and 18 (10.7%) TVFs in the angiography group (hazard ratio [HR]: 0.35; 95% confidence interval [CI]: 0.15–0.84; p = .01), whereas 35 TVFs occurred in patients without CKD, with 14 (2.6%) TVFs in the IVUS group and 21 (3.8%) TVFs in the angiography group (HR: 0.67; 95% CI: 0.34–1.32; p = .25; p for interaction = .24).ConclusionsThis study demonstrated that CKD patients undergoing DES implantations were associated with a higher risk of TVF at 12 months. More importantly, the risk of TVF in the CKD patients could be significantly decreased through IVUS guidance.Clinical TrialNCT02215915.
First‐in‐human experience with occlusion of the superior vena cava to reduce cardiac filling pressures in congestive heart failure
Authors: Kapur Navin K. , Karas Richard H. , Newman Sarah , Jorde Lena , Chabrashvili Tina , Annamalai Shiva , Esposito Michele , Kimmelstiel Carey D. , Lenihan Tim , Burkhoff Daniel 
Published: May 2019

AbstractBackgroundAcutely decompensated heart failure remains a major clinical problem. Volume overload promotes cardiac and renal dysfunction and is associated with increased morbidity and mortality in heart failure. We hypothesized that transient occlusion of the superior vena cava (SVC) will reduce cardiac filling pressures without reducing cardiac output or systemic blood pressure. The objective of this proof of concept study was to provide initial evidence of safety and feasibility of transient SVC occlusion in patients with acutely decompensated heart failure and reduced ejection fraction.Methods and ResultsIn eight patients with systolic heart failure, SVC occlusion was performed using a commercially available occlusion balloon. Five minutes of SVC occlusion reduced biventricular filling pressures without decreasing systemic blood pressure or total cardiac output. In three of the eight patients, a second 10‐minutes occlusion had similar hemodynamic effects. SVC occlusion was well‐tolerated without development of new symptoms, new neurologic deficits, or any adverse events including stroke, heart attack, or reported SVC injury or thrombosis at 7 days of follow up.ConclusionWe report the first clinical experience with transient SVC occlusion as a potentially new therapeutic approach to rapidly reduce cardiac filling pressures in heart failure. No prohibitive safety signal was identified and further testing to establish the clinical utility of transient SVC occlusion for acute decompensated heart failure is justified.
Kinetic Analysis of Catalytic Organic Reactions Using a Temperature Scanning Protocol
Authors: Schmidt Olivia P. , Dechert‐Schmitt Anne‐Marie , Garnsey Michelle R. , Wisniewska Hanna M. , Blackmond Donna G. 
Published: May 2019

AbstractExperimental and kinetic modelling studies are presented to describe the development of temperature scanning reaction progress protocol for batch reactions. Coupled with graphical manipulations, this approach enables the expansion of in‐situ kinetic studies from a focus on isothermal concentration profiles to include reaction temperature as a parameter for rapid kinetic and mechanistic analysis.
A Manganese N‐Heterocyclic Carbene Catalyst for Reduction of Sulfoxides with Silanes
Authors: Sousa Sara C. A. , Carrasco Carlos J. , Pinto Mara F. , Royo Beatriz 
Published: May 2019

AbstractThe first reduction of sulfoxides catalysed by a well‐defined manganese complex is described. A variety of sulfoxides are reduced to the corresponding sulfides in high yields using phenylsilane, diphenylsilane, and the economically feasible 1,1,3,3‐tetramethyldisiloxane (TMDS) as reducing agents in the presence of a Mn‐NHC complex. The reaction is performed under air and without the need of any additive. The involvement of radicals in the catalytic reaction is probed by spin‐trap experiments.
Synthesis and Antibacterial Evaluation of Bis‐thiazolium, Bis‐imidazolium, and Bis‐triazolium Derivatives
Authors: Thomas Benoît , Duval Raphaël E. , Fontanay Stéphane , Varbanov Mihayl , Boisbrun Michel 
Published: May 2019

AbstractGiven the worldwide spread of bacterial drug resistance, there is an urgent need to develop new compounds that exhibit potent antibacterial activity and that are unimpaired by this phenomenon. Quaternary ammonium compounds have been used for many years as disinfectants, but recent advances have shown that polycationic derivatives exhibit much stronger activity and are less prone to bacterial resistance than commonly used monocationic compounds. In this sense, we prepared three series of new bis‐cationic compounds: bis‐thiazoliums, bis‐imidazoliums, and bis‐1,2,4‐triazoliums. If some compounds of the first series showed fair antibacterial activity, most of those belonging to the two other series were highly potent, with minimum inhibitory concentrations close to 1 μg mL−1. Some of them also exhibited low toxicity toward eukaryotic MRC‐5 lung fibroblasts, and we showed that this toxicity is clearly correlated with clogP. Finally, four selected compounds were found to exhibit a clear bactericidal effect.
Multivalency in Heteroternary Complexes on Cucurbit[8]uril‐Functionalized Surfaces: Self‐assembly, Patterning, and Exchange Processes
Authors: Valderrey Virginia , Wiemann Maike , Jonkheijm Pascal , Hecht Stefan , Huskens Jurriaan 
Published: May 2019

AbstractThe spatial confinement of multivalent azopyridine guest molecules mediated by cucurbit[8]urils is described. Fluorescent dye‐labelled multivalent azopyridine molecules were attached to preformed methyl viologen/cucurbit[8]uril inclusion complexes in solution and at surfaces. The formation of the resulting heteroternary host–guest complexes was verified in solution and on gold substrates. Surface binding constants of the multivalent ligands were two orders of magnitude higher than that of the monovalent one. Poly‐l‐lysine grafted with oligo(ethylene glycol) and maleimide moieties was deposited on cyclic olefin polymer surfaces and further modified with thiolated methyl viologen and cucurbit[8]uril. Defined micrometer‐sized patterns were created by soft lithographic techniques. Supramolecular exchange experiments were performed on these surface‐bound heterocomplexes, which allowed the creation of cross‐patterns by taking advantage of the molecular valency, which led to the substitution of the monovalent guest by the multivalent guests but not vice versa.
Pyrrolopyrrole Aza‐BODIPY Analogues as Near‐Infrared Chromophores and Fluorophores: Red‐Shift Effects of Substituents on Absorption and Emission Spectra
Authors: Kage Yuto , Karasaki Hideaki , Mori Shigeki , Furuta Hiroyuki , Shimizu Soji 
Published: May 2019

AbstractPyrrolopyrrole aza‐BODIPY analogues (PPABs) are a new class of UV/vis and near‐infrared chromophores. Varying the substituents results in red‐shifts of both the absorption and emission spectra. Extension of the lengths of the oligothiophene substituents from thiophene to quaterthiophene caused red‐shifts of the absorption and emission from 699 and 712 nm to 809 and 853 nm, respectively. The piperidylthiophene‐substituted PPAB exhibited similar red‐shifts of the absorption and emission to 810 and 831 nm, respectively, although only a single thienyl component is present, because of the strong electron‐donating nature of the piperidine substituent.
Ice‐margin fluctuation sequences and grounding zone wedges: The record of the Late Palaeozoic Ice Age in the eastern Karoo Basin (Dwyka Group, South Africa)
Authors: Dietrich Pierre , Hofmann Axel 
Published: May 2019

AbstractIn the eastern part of the Karoo Basin of South Africa, the sedimentary record of the Late Palaeozoic Ice Age, the Dwyka Group, consists of an up to 200 m thick accumulation of massive to crudely stratified diamictite occasionally interstratified with siltstone, sandstone and conglomerate horizons. Three distinct sedimentary units, separated by intervening glacial erosion surfaces, are viewed as ice‐margin fluctuation sequences. The lowermost one, resting on highly uneven, glacially abraded Archaean basement, has been interpreted as a grounding zone wedge deposited after the retreat and stabilization of the ice margin after the inundation of the Karoo Basin. The grounding zone wedge interpretation is based on its thickness (up to 100 m), the dominance of diamictite, and its facies assemblage and inferred depositional processes (rain‐out of debris, dropstone dumping, mass and debris flow, till). Overlying the grounding zone wedge, deposits are sedimentary units interpreted as glaciofluvial or ice‐contact delta and grounding zone wedges, respectively. By analogy with Quaternary sedimentary sequences, deposition of the Dwyka Group in the study area might have been very rapid (tens to hundreds of thousand years) and may hence correlate with the ultimate deglacial sequence of the Western Karoo Basin, as both successions are covered by the postglacial Ecca Group. Although commonly observed and imaged on modern, high‐latitude continental shelves, grounding zone wedges have never been interpreted in the ancient geological record. This paper therefore outlines a model defining criteria necessary for their identification.