bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiometabolic Risk Profile Among Young Adult Females With a History of Premature Adrenarche
Authors: Liimatta Jani , Utriainen Pauliina , Laitinen Tomi , Voutilainen Raimo , Jääskeläinen Jarmo 
Published: July 2019

Abstract

Context
Premature adrenarche (PA) is associated with childhood overweight and hyperinsulinemia; the long-term cardiometabolic outcome is unknown.

Objective
To study cardiometabolic profile in adult women with previous PA.

Design and participants
Thirty women with PA and 41 control subjects were followed from prepuberty to young adulthood.

Main outcome measures
Prevalence of the metabolic syndrome (MetS) and clinical and biochemical cardiovascular risk factors.

Results
There were no differences in the prevalence of MetS or in any parameters indicating dyslipidemia, hypertension, hepatosteatosis, atherosclerosis, or low-grade inflammation between the study groups. However, prevalence of insulin resistance (IR; P = 0.014) and acanthosis nigricans (P = 0.010) was higher in the PA group. Neither fasting glucose nor insulin concentrations differed between the study groups, but HbA1c [adjusted for body mass index (BMI) P = 0.011] and Homeostatic Model Assessment of Insulin Resistance (P = 0.044; BMI-adjusted P = nonsignificant) were higher in the PA group. Although BMI and fat percentage were comparable between the study groups, the PA group had higher central fat mass than the control group. In the whole study population, MetS and IR were associated with greater adult fat mass, but no prepubertal factors predicting later IR were found.

Conclusion
PA does not seem to be associated with MetS, dyslipidemia, hypertension, atherosclerosis, or low-grade inflammation in young adult women. However, some women with PA may be at an increased risk of unfavorable glucose metabolism, which is associated with increased central adiposity at adult age rather than determined by prepubertal factors.
Solution Focused brief therapy In post-stroke Aphasia (SOFIA Trial): protocol for a feasibility randomised controlled trial
Authors: Northcott Sarah , Simpson Alan , Thomas Shirley A. , Hirani Shashivadan P. , Flood Chris , Hilari Katerina 
Published: July 2019

Background: Around a quarter of people post stroke will experience aphasia, a language disability. Having aphasia places someone at risk of becoming depressed and isolated. There is limited evidence for effective interventions to enhance psychological well-being for this client group. A potential intervention is Solution Focused Brief Therapy (SFBT), which supports a person to build meaningful, achievable change through focusing on a person’s skills and resources rather than their deficits. The SOFIA Trial aims to explore the acceptability of SFBT to people with varying presentations of aphasia, including severe aphasia, and to assess the feasibility of conducting a future definitive trial investigating clinical and cost effectiveness. Methods: The trial is a single-blind, randomised, wait-list controlled feasibility trial with nested qualitative research and pilot economic evaluation comparing SFBT plus usual care to usual care alone. The study will recruit 32 participants with aphasia who are ≥6 months post stroke. All participants will be assessed on psychosocial outcome measures at baseline, three, and six months post randomisation by assessors blinded to treatment allocation. Participants will be randomly assigned to intervention group (start intervention immediately post randomisation) or wait-list group (start intervention six months post randomisation). Wait-list group will additionally be assessed nine months post randomisation. The intervention consists of up to six SFBT sessions delivered over three months by speech and language therapists. Participants and therapists will also take part in in-depth interviews exploring their experiences of the study. The pilot economic evaluation will use the EQ-5D-5L measure and an adapted Client Service Receipt Inventory. People with aphasia have been involved in designing and monitoring the trial. Discussion: Given the high levels of depression and isolation, there is a need to investigate effective interventions that enhance the psychological wellbeing of people with aphasia. Trial registration: ClinicalTrials.gov NCT03245060 10/08/2017.
Infection after fracture fixation
Authors: Steinmetz Sylvain , Wernly Diane , Moerenhout Kevin , Trampuz Andrej , Borens Olivier 
Published: July 2019

Infection after fracture fixation is a feared complication in orthopaedic surgery leading to poor bone healing and loss of function. Early detection is essential and interdisciplinary care is mandatory. Eradication of infection is only possible through combined surgical and antibiotic treatment. Intraoperative tissue samples must be taken and are effective for guidance of the antibiotic regimen. Infection after fracture fixation is different from prosthetic joint infection (PJI) and needs a specific strategy. In this review, we define infection after fracture fixation, and outline the clinical, radiological and laboratory signs of these infections, as well as a treatment algorithm for optimal patient care.Cite this article: EFORT Open Rev 2019;4:468-475. DOI: 10.1302/2058-5241.4.180093
18Fluorocholine PET/CT scanning with arterial phase-enhanced CT is useful for persistent/recurrent primary hyperparathyroidism: first UK case series results
Authors: Christakis I , Khan S , Sadler GP , Gleeson FV , Bradley KM , Mihai R 
Published: July 2019

Introduction Redo parathyroidectomy for persistent/recurrent primary hyperparathyroidism is associated with a higher risk of complications and should be planned only with convincing localisation. We assessed whether 18fluorocholine positron emission tomography/computed tomography could identify parathyroid adenoma(s) in patients with persistent/recurrent primary hyperparathyroidism and negative conventional scans. Materials and methods A departmental database was used to identify patients with failed localisation attempts (sestamibi single photon emission computed tomography/computed tomography and/or computed tomography/magnetic resonance imaging and/or selective parathyroid hormone sampling) after previous unsuccessful surgery for primary hyperparathyroidism. 18Fluorocholine positron emission tomography was performed in all patients and redo surgery offered to those with positive findings. Results 18Fluorocholine positron emission tomography incorporating arterial and portal phase enhanced computed tomography was performed in 12 patients with persistent/recurrent primary hyperparathyroidism (four men and eight women). Seven patients (58%) were cured after excision of adenomas located in ectopic positions (n = 3) or in anatomical position (n = 4). Five patients (42%) had persistent hypercalcaemia and repeat 18fluorocholine scan confirmed that the area highlighted on preoperative scans was excised. The arterial phase enhancement of the computed tomography was significantly different between cured and not-cured patients (P = 0.007). All seven cured patients had either a strong or weak enhancing pattern on computed tomography. Standardised uptake value at 60 minutes in patients with successful surgery (range 2.7–15.7, median 4.05) was higher than in patients with failed surgery (range 1.8–5.8, median 3.2) but was not statistically significant (P = 0.300). Discussion 18fluorocholine scanning can identify elusive parathyroid adenomas, including those that are ectopic, and is useful in the management of patients with persistent/recurrent primary hyperparathyroidism when first-line scans are negative. The grading of the arterial phase of computed tomography can help to differentiate between true adenomas and false positive targets (lymph nodes).
Detection of Neprilysin-Derived BNP Fragments in the Circulation: Possible Insights for Targeted Neprilysin Inhibition Therapy for Heart Failure
Authors: Feygina Evgeniya E , Artemieva Marina M , Postnikov Alexander B , Tamm Natalia N , Bloshchitsyna Marina N , Medvedeva Natalia A , Katrukha Alexey G , Semenov Alexander G 
Published: July 2019

Abstract

BACKGROUND
Entresto™ is a new heart failure (HF) therapy that includes the neprilysin (NEP) inhibitor sacubitril. One of the NEP substrates is B-type natriuretic peptide (BNP); its augmentation by NEP inhibition is considered as a possible mechanism for the positive effects of Entresto. We hypothesized that the circulating products of BNP proteolysis by NEP might reflect NEP impact on the metabolism of active BNP. We suggest that NEP-based BNP cleavage at position 17–18 results in BNP ring opening and formation of a novel epitope with C-terminal Arg-17 (BNP-neo17 form). In this study, we use a specific immunoassay to explore BNP-neo17 in a rat model and HF patient plasma.

METHODS
We injected BNP into rats, with or without NEP inhibition with sacubitril. BNP-neo17 in plasma samples at different time points was measured with a specific immunoassay with neglectable cross-reactivity to intact forms. BNP-neo17 and total BNP were measured in EDTA plasma samples of HF patients.

RESULTS
BNP-neo17 generation in rat circulation was prevented by NEP inhibition. The maximum 13.2-fold difference in BNP-neo17 concentrations with and without sacubitril was observed at 2 min after injection. BNP-neo17 concentrations in 32 HF patient EDTA plasma samples ranged from 0 to 37 pg/mL (median, 5.4; interquartile range, 0–9.1). BNP-neo17/total BNP had no correlation with total BNP concentration (with r = −0.175, P = 0.680) and showed variability among individuals.

CONCLUSIONS
BNP-neo17 formation is NEP dependent. Considering that BNP-neo17 is generated from the active form of BNP by NEP, we speculate that BNP-neo17 may reflect both the NEP activity and natriuretic potential and serve for HF therapy guidance.
Diagnosis of Eosinophilic Enteritis With Video Capsule Endoscopy and Double Balloon Enteroscopy With Favorable Response to Corticosteroids
Authors: Herrera Quiñones Gilberto , Scharrer Susanna Isabel , Jiménez Rodríguez Alan Rafael , García Compean Diego , Borjas Almaguer Omar David , Martínez Segura Juan Antonio , Jáquez Quintana Joel Omar , González González Jose Alberto , Maldonado Garza Hector Jesus 
Published: July 2019

ABSTRACT
Eosinophilic enteritis is a rare disease with nonspecific symptoms, often representing a diagnostic challenge. Video capsule endoscopy (VCE) has enabled examination of the full small bowel. However, capsule retention is an unfortunate complication. We present the case of a female patient admitted for abdominal pain. Appendectomy without resolution of symptoms was performed. A normal computed tomography and magnetic resonance imaging were obtained. The diagnosis was made by VCE and double balloon enteroscopy with biopsy. Asymptomatic capsule retention was resolved after corticosteroid therapy. The patient showed a favorable clinical and endoscopic response, confirmed through a second VCE after 3 months of treatment.
Zieve's Syndrome Presenting With Severe Hypertriglyceridemia
Authors: Choudhry Faiza , Kathawa Jolian , Kerton Kelsey , Farshadsefat Seina , Piper Marc 
Published: July 2019

ABSTRACT
Zieve's syndrome (ZS) is a rare disease characterized by a triad of hemolytic anemia, cholestatic jaundice, and transient hyperlipidemia seen in patients with alcoholic steatohepatitis. We report a case of ZS with severe hypertriglyceridemia. Among the reported cases of ZS in English literature, we believe this is the first case of the syndrome presenting with severe hypertriglyceridemia requiring plasmapheresis.
Corrigendum: Medullary thyroid cancer. Returning to the need to determine the preoperative basal calcitonin level in patients with thyroid nodular pathology (Endocrine surgery. 2018;12(4). doi: 10.14341/serg10044)
Authors: Stanyakina Elena E. , Romanov Ilia S. , Kondratieva Tatiana T. , Krylov Alexander S. , Ryzhkov Alexey D. , Shiryaev Sergey V. 
Published: July 2019

A corrigendum on «Medullary thyroid cancer. Returning to the need to determine the preoperative basal calcitonin level in patients with thyroid nodular pathology»
by Elena E. Stanyakina, Ilia S. Romanov, Tatiana T. Kondratieva, Alexander S. Krylov, Alexey D. Ryzhkov, Sergey V. Shiryaev (2018). Endocrine Surgery. 12(4). doi: 10.14341/serg10044
There is an error on the page 189: "Blood test for hormones: thyroid stimulating hormone (TSH) — 52.6 mIU/l (reference values 0.25–4.0), adrenocorticotropic hormone (ACTH) <20 IU/ml (0–30), thyreoglobulin (TG) <0.2 ng/ml (0–30)". Instead of "antibodies to thyroglobulin (ATTG)" was published "adrenocorticotropic hormone (ACTH)".
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.
The original article has been updated.
Technological Cooperation Trends Under Conditions of the Modern World Economy
Authors: Anatol’evna Navrotskaia Natalia , Alexandrovna Kovaleva Ekaterina , Vyacheslavovna Zenkina Elena , Muradovna Kutlyeva Gozel’ , Vyacheslavovna Bogacheva Tatyana , Vital’evna Bondarchuk Nataliya 
Published: July 2019

The authors emphasized key specific features of technological cooperation under conditions of the modern world economy and analyze modern trends of the world production ties development in high and medium technological economic sectors. They generalized main trends of technological cooperation development in the light of structural changes in the world economy, innovative production process and specific features of regional labor division. It was concluded that structural changes in the world economy, an innovative production process and specific features of regional labor division formed a new location of the world production, an architecture and motivation of technological cooperation in the hi-tech and economic sectors. It was emphasized that an analysis of technological cooperation development for Russia should be performed with account of the mentioned world tendencies and special features of the national economy.
Parameters Affecting Coating Uniformity of Alkali -Activated Material Coated Fertilizer
Authors: Hakim H Luqman , Zilati KZ. Ku. , Harris N. Muhammad 
Published: July 2019

The establishment of Controlled Release Urea (CRU) in agriculture industry has given a great significant outcome towards the development of economy while preserving the environment. As it is developed through a coating process, it does not only help to increase fertilizer’s efficiency, but also minimize the loss of nutrients into the soil and environmental pollution. There are many types of coating materials that have been extensively studied as well as applied in everyday life from pharmaceutical industry to engineering industry such as in pharmaceutical tablet, road construction and corrosion control of steel structures like offshore platforms. In this research, the alkali-activated material composite has been developed as a new coating material and is introduced as the main coating material for the CRU. In term of environmental friendliness, alkali-activated material (AAM) is considered better than sulphur and polymer. However, the combination of fly ash and sodium hydroxide (NaOH) solution producing the AAM paste needs further research since it can be categorized as a novel coating material for CRU. It is also to ensure the suitability of it to be used as a coating material on urea fertilizer. A significant coating thickness along with good hardness strength can produce promising coated urea granules characteristics. Two parameters have been studied for this research to identify its effect towards coating thickness and hardness strength of coated urea granules which are inlet air pressure and spraying rate. These two parameters are identified to be crucial in enhancing the characteristics of coated urea granules.
Selection of Suitable Supervised Classification Techniques for the Geographic Analysis of Land Using GIS Techniques
Authors: L. Senthil Lekha S , S.Kumar S 
Published: July 2019

Nation has realised the changes in the land surface and the influence of this in the whole ecosystem. The activities of human on land is directly deteriorating the environment quality. This paper mainly focuses on the analysis of the destruction of land cover with the development of land use. The performance of five different Supervised Classification algorithms, which are Parallelepiped, Mahalanobis, Neurel Net, Adaptive Coherence and Spectral Angle Mapper have been analysed in classifying the Landsat Image of kanyakumari district. Automatic classification of five classes using training data have been performed and the best suitable algorithm for the classification of each class have been analysed. Being a tourism centre with coastal areas on all three sides, the development and the deterioration of kanyakumari district have to be monitored constantly. The proposed system is an automatic approach which helps in the analysis of the patterns of land use and land cover which constantly changes and to map each class clearly and distinct from each other using GIS techniques. The system was evaluated using the performance measures like accuracy and kappa coefficient using the tools Envi, ArcGIS and QGIS. From the performance analysis, the Spectral Angle Mapper with an overall accuracy of 97% and kappa coefficient of 0.54 has been selected as the best suitable algorithm for the classification of landsat image of kanyakumari district.
Mobile Cloud-Privacy and Data Security in Healthcare Environment Using Cloudsim Simulator
Authors: Parameswari R , Vani K 
Published: July 2019

The advancement of telecommunication in the medical field makes the diagnosis and treatment of patients in a faster manner because the patient information are stored and maintained in an electronic storage device. But there are some issues related to physical data storage, privacy by accessing user data and security etc. With the help of the cloud computing these issues are reduced now. The mobile health care system can improve the quality of patient care and reduce a medical cost for both patients and hospitals. The simulation tool CloudSim is used to generate the data center details, provider’s details and processing time. For the analysis, the cloud analyst tool can simulate the data center and others. The patient information in the Healthcare Information System (HIS) and Electronic Medical Records (EMRs) is stored in a data center or cloud platform in a secure manner.
Driving Two Numerical Methods to Evaluate the Triple Integrals R(MSM),R(SMM) and Compare Between Them
Authors: M. Aljassas Safaa , H.A. Alsharify Fouad , A.M. Al–Karamy Nada 
Published: July 2019

The main objective of present work is the conclusion of two new numerical methods to evaluate the triple integrals with continuous integrands and their partial derivatives are continuous too, the first method through using Mid-point rule on the interior dimension X, Simpson's rule on the middle dimension Y and Mid-point rule on the exterior dimension Z, which denoted by the symbol MSM. The second method by using Mid-point rule on both two dimensions of interior X and middle dimension Y and Simpson's rule on the exterior dimension Z which denoted by SMM, where the number of divisions on the three dimensions are equals. We have concluded two theorems with their proves to find their rules and the correction terms that we found it and to improve the results we used Romberg acceleration which denoted by R(MSM),R(SMM) where we got high accuracy in the results by little sub-intervals relatively and short time.
Convolutional Neural Network Based Image Denoising for Better Quality of Images
Authors: Gopatoti Anandbabu , Chandra Naik Merajothu , Kumar Gopathoti Kiran 
Published: July 2019

This work gives a survey by comparing the different methods of image denoising with the help of wavelet transforms and Convolutional Neural Network. To get the better method for Image denoising, there is distinctive merging which have been used. The vital role of communication is transmitting visual information in the appearance of digital images, but on the receiver side we will get the image with corruption. Therefore, in practical analysis and facts, the powerful image denoising approach is still a legitimate undertaking. The algorithms which are very beneficial for processing the signal like compression of image and denoising the image is Wavelet transforms. To get a better quality image as output, denoising methods includes the maneuver of data of that image. The primary aim is wavelet coefficient modification inside the new basis, by that the noise within the image data can be eliminated. In this paper, we suggested different methods of image denoising from the corrupted images with the help of different noises like Gaussian and speckle noises. This paper implemented by using adaptive wavelet threshold( Sure Shrink, Block Shrink, Neigh Shrink and Bivariate Shrink) and Convolutional Neural Network(CNN) Model, the experimental consequences the comparative accuracy of our proposed work.
Energy Audit with Innovative Technology Management for Resourcing the Clean Energy and Sustainability in India
Authors: Sivapriya C , Preetha S , Rajendran V 
Published: July 2019

Energy is an essential input to the overall development of the economy. It provides light and fuel to millions of households, industry, agriculture, commerce all service sectors and so on. Since energy is a critical component, development of conventional and non-conventional forms of energy for meeting the growing demand of the society at reasonable price and quality is the responsibility of the government. Energy Audit is an important and vital tool in the management of energy both at industry and nation level. It is required for improvising the efficient management practices in energy production, utilization and distribution with better technology and to thereby conserve for future growth and development. With the growing importance for industrial sectors in the country’s development and increasing energy consumptions, it has become essential and necessity to opt for more optimization methods in the consumption of energy. A saving of 15 to 30% can be done by optimal usage of energy at home. Energy conservation and safety is the topmost priority in today’s world to have a consistent growth, increase in production and to protect our environment. Energy audit and its management is instrumental to cope with the variation in the cost of energy, to identify the appropriate mixes of energy, to improvise the energy conservative equipment and technologies. Along with innovative technology for energy consumptions we also require innovative methods in the management of energy audit to help the country with efficient energy management system, reduce cost and save energy for future requirements. To study and understand the need for Energy audit with innovative technology management in India. To analyze its importance for resourcing clean energy and sustainability in India.
Relationship the Fuzzy P-Ideal with Some Fuzzy Subset of BH-Algebra
Authors: Abdulaali Neamah Suad , . . 
Published: July 2019

This work involved some studying ,we study and prove some theorems and a propositions which determine the relationships among the notion of fuzzy p-ideal with the intersection, union, image of function, inverse function and with some other fuzzy subsets of BH-algebra, also we gave some properties of this ideal of a BH-algebra.