bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absceso gingival después de aumento de reborde alveolar con técnica en rollo modificada. Reporte de caso / Gingival Abscess after Alveolar Ridge Increase with Modified Roll Technique: A Case Report
Authors: Molano Valencia Pablo Emilio , Yepes Ramírez Bibiana Inés , Varela Peñaranda Alix María 
Published: September 2018

RESUMEN. Antecedentes: La técnica en rollo modificado se ha utilizado ampliamente para mejorar el aspecto estético de las deficiencias de rebordes alveolares durante el tratamiento de rehabilitación y disminuir dolor posoperatorio. Objetivo: Describir un caso clínico en el que se realizó un aumento del reborde alveolar por medio de técnica en rollo modificada y se presentó un absceso durante las primeras semanas posoperatorias. Se describe también manejo clínico del caso. Resultados: Después del diagnóstico clínico y microbiológico, se realizó tratamiento antibiótico. En el control a los cuatro meses se observó resolución completa del absceso.ABSTRACT. Background: The modified roll technique has been widely used to improve the aesthetic appearance of alveolar ridge deficiencies during the oral rehabilitation treatments and to reduce postoperative pain. Purpose: To describe a case of alveolar ridge increase through modified roll technique and an abscess that occurred during the initial postoperative weeks. The clinical treatment of the case is also described. Results: After clinical and microbiological diagnosis, the patient underwent antibiotic therapy. Four-month follow-up showed complete resolution of the abscess.
Association between mitochondrial DNA damage and ocular blood flow in patients with glaucoma
Authors: Inoue-Yanagimachi Maki , Himori Noriko , Sato Kota , Kokubun Taiki , Asano Toshifumi , Shiga Yukihiro , Tsuda Satoru , Kunikata Hiroshi , Nakazawa Toru 
Published: September 2018

Background/AimsWe determined the relationship between tissue mean blur rate (MT) and mitochondrial dysfunction, represented by the mitochondrial/nuclear DNA (mtDNA/nDNA) ratio. We also investigated the usefulness of these biomarkers.MethodsWe assessed ocular blood flow in 123 eyes of 123 patients with open-angle glaucoma (OAG) and 37 control eyes of 37 healthy subjects by measuring MT in the optic nerve head with laser speckle flowgraphy. We measured mtDNA and nDNA with PCR, calculated the mtDNA/nDNA ratio and compared this ratio with MT using Spearman’s rank test. We used multiple regression analysis to further investigate the association between MT and glaucoma in the most severe group.ResultsThe control and the patients with glaucoma had significant differences in the mtDNA/nDNA ratio, circumpapillary retinal nerve fibre layer thickness and MT. There was no significant relationship between the mtDNA/nDNA ratio and MT in patients with OAG overall or the female patients with OAG, but there was a significant relationship between the mtDNA/nDNA ratio and MT, temporal-MT and superior-MT in male patients with severe OAG (r=−0.46, p=0.03; r=−0.51, p=0.02; r=−0.61, p<0.01, respectively). Furthermore, we found that the mtDNA/nDNA ratio was an independent contributor to temporal-MT and superior-MT in these patients (p<0.01 and p=0.03, respectively).ConclusionWe found that there was a significant relationship between the mtDNA/nDNA ratio and MT in male patients with severe OAG, suggesting that the mtDNA/nDNA ratio may be a new biomarker in glaucoma and may help research on the vulnerability of these patients to mitochondrial dysfunction.
Identification of new-onset atrial fibrillation after cardiac surgery in Vietnam. A feasibility study of a novel screening strategy in a limited-resource setting: study protocol
Authors: Ngo Thi Hai Linh , Vu Van Ba , Nguyen Cong Huu , Le Tien Dung , Hoang Trung Kien , Freedman Ben , Lowres Nicole 
Published: September 2018

IntroductionAtrial fibrillation (AF) developing after cardiac surgery is the most common postoperative complication with an incidence up to 50%. The presence of postoperative AF is associated with significant morbidity, mortality and economic burden. However, in Vietnam, data on AF postcardiac surgery are limited, in part due to a shortage of screening equipment. This project aims to identify the incidence, risk factors and postoperative complications of new-onset postoperative AF after cardiac surgery, and the feasibility of introducing a novel screening strategy using the combination of two portable devices to detect AF.Methods and analysisThis is a feasibility study examining patients who are (1) ≥18 years old; (2) undergoing coronary artery bypass graft and/or valve surgery and (3) in normal sinus rhythm prior to their operation. Patients with congenital heart disease, a prior history of AF or those who require a pacemaker after surgery will be excluded. All patients will be followed up for the duration of their hospitalisation. The screening strategy will include monitoring the continuous ECG tracing in the intensive care unit, and if AF is suspected, a 30 s lead-1 ECG will be recorded using the smartphone-based AliveCor Kardia Mobile. On the postoperative wards, blood pressure will be measured three times daily using a modified blood pressure device (Microlife BP200 Afib): and if AF is suspected a 30 s ECG will be recorded using the AliveCor Kardia Mobile. A 12-lead ECG may be ordered subsequently if clinically indicated. The primary outcome is the incidence of postoperative AF. Secondary outcomes include establishing the risk factors and complications associated with postoperative AF; and the barriers and facilitators of the screening strategy.Ethics and disseminationEthics approval was granted by Scientific Board of Cardiovascular Centre, E Hospital on 28 September, 2017. Study results will be disseminated through local and international conferences and peer-reviewed publications.
Anastomotic leakage after intrathoracic versus cervical oesophagogastric anastomosis for oesophageal carcinoma in Chinese population: a retrospective cohort study
Authors: Liu Yin-jiang , Fan Jun , He Huang-he , Zhu Shu-sheng , Chen Qiu-lan , Cao Rong-hua 
Published: September 2018

ObjectiveTo investigate the characteristics and predictors for anastomotic leakage after oesophagectomy for oesophageal carcinoma from the perspective of anastomotic level.DesignRetrospective cohort study.SettingsA single tertiary medical centre in China.ParticipantsFrom January 2010 to December 2016, all patients with oesophageal cancer of the distal oesophagus or gastro-oesophageal junction undergoing elective oesophagectomy with a curative intent for oesophageal carcinoma with intrathoracic oesophagogastric anastomosis (IOA) versus cervical oesophagogastric anastomosis (COA) were included. We investigated anastomotic level and perioperative confounding factors as potential risk factors for postoperative leakage by univariate and multivariate logistic regression.Primary outcome measuresThe primary outcome was the odds of anastomotic leakage by different confounding factors. Secondary outcome was the association of IOA versus COA with other postoperative outcomes.ResultsOf 458 patients included, 126 underwent cervical anastomosis and 332 underwent intrathoracic anastomosis. Anastomotic leakage developed in 55 patients (12.0%), with no statistical differences between COA and IOA (16.6% vs 10.2%; p=0.058). Multivariable analysis identified active diabetes mellitus (OR 2.001, p=0.047), surgical procedure (open: reference; minimally invasive: OR 1.770, p=0.049) and anastomotic method (semimechanical: reference; stapled: OR 1.821; handsewn: OR 2.271, p=0.048) rather than anastomotic level (IOA: reference; COA: OR 1.622, p=0.110) were independent predictors of leakage.ConclusionsSurgical and anastomotic techniques rather than the level of anastomotic site were independent predictors of postoperative anastomotic leakage in patients undergoing oesophageal cancer surgery.
Physical activity and concussion risk in youth ice hockey players: pooled prospective injury surveillance cohorts from Canada
Authors: Blake Tracy A , Doyle-Baker Patricia K , Brooks Brian L , Palacios-Derflingher Luz , Emery Carolyn A 
Published: September 2018

ObjectiveTo examine the association between meeting physical activity (PA) volume recommendations and concussion rates in male ice hockey players aged 11–17 years.DesignPooled prospective injury surveillance cohort data from the 2011–2012, 2013–2014 and 2014–2015 youth ice hockey seasons.ParticipantsMale Alberta-based Pee Wee (aged 11–12 years), Bantam (aged 13–14 years) and Midget (aged 15–17 years) ice hockey players participating in any of the three cohorts were eligible (n=1726). A total of 1208 players were included after the exclusion criteria were applied (ie, players with new/unhealed injuries within 6 weeks of study entry, missing 6-week PA history questionnaires, missing game and/or practice participation exposure hours, players who sustained concussions when no participation exposure hours were collected).Outcome measuresDependent variable: medically diagnosed concussion. Independent variable: whether or not players’ self-reported history of PA (ie, hours of physical education and extracurricular sport participation) met the Canadian Society of Exercise Physiology and Public Health Agency of Canada recommendation of one hour daily during the 6 weeks prior to study entry (ie, 42 hours or more).ResultsThe PA volume recommendations were met by 65.05% of players who subsequently sustained concussions, and 75.34% of players who did not sustain concussions. The concussion incidence rate ratios (IRR) reflect higher concussion rates in players who did not meet the PA volume recommendations vs. players who met the PA volume recommendations among Pee Wee players (IRR 2.94 95% CI 1.30 to 6.64), Bantam players (IRR 2.18, 95% CI 1.21 to 3.93) and non-elite players aged 11–14 years (IRR 2.45, 95% CI 1.33 to 4.51).Conclusion and relevanceThe concussion rate of players who did not meet the Canadian PA volume recommendations was more than twice the concussion rate of players who met recommendations among male Pee Wee players, Bantam players and non-elite level players. Further exploration of the impact of public health PA recommendations in a sport injury prevention context is warranted.
Work of being an adult patient with chronic kidney disease: a systematic review of qualitative studies
Authors: Roberti Javier , Cummings Amanda , Myall Michelle , Harvey Jonathan , Lippiett Kate , Hunt Katherine , Cicora Federico , Alonso Juan Pedro , May Carl R 
Published: September 2018

IntroductionChronic kidney disease (CKD) requires patients and caregivers to invest in self-care and self-management of their disease. We aimed to describe theworkfor adult patients that follows from these investments and develop an understanding of burden of treatment (BoT).MethodsSystematic review of qualitative primary studies that builds on EXPERTS1 Protocol, PROSPERO registration number: CRD42014014547. We included research published in English, Spanish and Portuguese, from 2000 to present, describing experience of illness and healthcare of people with CKD and caregivers. Searches were conducted in MEDLINE, Embase, CINAHL Plus, PsycINFO, Scopus, Scientific Electronic Library Online and Red de Revistas Científicas de América Latina y el Caribe, España y Portugal. Content was analysed with theoretical framework using middle-range theories.ResultsSearches resulted in 260 studies from 30 countries (5115 patients and 1071 carers). Socioeconomic status was central to the experience of CKD, especially in its advanced stages when renal replacement treatment is necessary. Unfunded healthcare was fragmented and of indeterminate duration, with patients often depending on emergency care. Treatment could lead to unemployment, and in turn, to uninsurance or underinsurance. Patients feared catastrophic events because of diminished financial capacity and made strenuous efforts to prevent them. Transportation to and from haemodialysis centre, with variable availability and cost, was a common problem, aggravated for patients in non-urban areas, or with young children, and low resources. Additional work for those uninsured or underinsured included fund-raising. Transplanted patients needed to manage finances and responsibilities in an uncertain context. Information on the disease, treatment options and immunosuppressants side effects was a widespread problem.ConclusionsBeing a person with end-stage kidney disease always implied high burden, time-consuming, invasive and exhausting tasks, impacting on all aspects of patients' and caregivers’ lives. Further research on BoT could inform healthcare professionals and policy makers about factors that shape patients’ trajectories and contribute towards a better illness experience for those living with CKD.PROSPERO registration numberCRD42014014547.
Risk factors for new-onset atrial fibrillation on the general adult ICU: protocol for a systematic review
Authors: Bedford Jonathan , Harford Mirae , Petrinic Tatjana , Young J Duncan , Watkinson Peter J 
Published: September 2018

IntroductionAtrial fibrillation (AF) is a common arrhythmia in the critical care environment. New-onset AF is associated with increased mortality and intensive care unit (ICU) length of stay. Observational studies have identified several epidemiological and disease severity-related factors associated with developing new-onset AF on the ICU. However, there are limited data on the modifiable risk factors in the general adult ICU population.We describe a protocol for a systematic review of modifiable and non-modifiable risk factors for new-onset AF in the general adult ICU population. The results of this review will aid the development of risk prediction tools and inform future research into AF prevention on the ICU.Methods and analysisMedical Literature Analysis and Retrieval System Online, Excerpta Medica database and the Cochrane Library, including Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials will be searched for studies that assess the association of patient variables, investigation results, interventions and diagnoses associated with subsequent new-onset AF on the ICU.Only studies involving adult patients admitted to non-service-specific ICUs will be included. We will extract data relating to the statistical association between reversible and non-reversible factors and AF, the quality of the studies and the generalisability of the results. This systematic review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.Ethics and disseminationThis proposed systematic review will be based on published data, and therefore ethical approval is not required. The findings of this study will be disseminated through publication in a peer reviewed journal and will be presented at conferences.PROSPERO registration numberCRD42017074221.
Serum albumin at 1 year predicts long-term renal outcome in lupus nephritis
Authors: Domingues Vinicius , Levinson Benjamin A , Bornkamp Nicole , Goldberg Judith D , Buyon Jill , Belmont H Michael 
Published: September 2018

ObjectivesThe study aimed to determine if serum albumin at 12 months predicts long-term renal outcome at 48 months. Data from the NYU SAMPLE (Specimen and Matched Phenotype Linked Evaluation) Lupus Registry were used to compare the performance of albumin, anti-double-stranded DNA, C3/C4, proteinuria and haematuria.Methods82 patients with SLE with data at time of renal biopsy, at 12 months and at a second visit, and up to 48 months were included. The significance of each biomarker as a predictor of an adverse renal outcome (ARO), defined as doubling of serum creatinine, as creatinine >4 mg/dL if initial >2.5 mg/dL or ESRD, was evaluated in univariate and exploratory multivariable Cox proportional hazards models. Hazard ratios (HRs) for ARO with 95% CIs were generated. The receiver operating characteristic (ROC) curves at 48 months were used to identify the optimal cut-off point for albumin and proteinuria to predict ARO. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for albumin and proteinuria.ResultsSerum albumin and proteinuria had statistically significant HRs for ARO (0.140 and 1.459, respectively). The model with both albumin and proteinuria indicated no additional independent contribution of proteinuria to albumin alone. The ROC curves identified cut-offs of 3.7 g/dL for albumin and 0.964 urine protein to creatinine ratio for proteinuria. Albumin had a sensitivity of 94%, specificity of 87%, PPV of 64% and NPV of 98%.ConclusionsThis study demonstrates serum albumin >3.7 g/dL is a predictor of a favourable long-term renal outcome. These results support the inclusion of albumin as an outcome in lupus nephritis trials and treat-to-target guidelines.
Asymptotically Maximal Throughput in Tandem Systems with Flexible and Dedicated Servers
Authors: Zou Aili Alice , Down Douglas G. 
Published: September 2018

For a system of two tandem queues with a finite intermediate buffer, we study the asymptotically maximal throughput as the number of servers in each station grows to infinity. First, we study the system with only dedicated servers, and then we examine the system with both dedicated and flexible servers. We assume that travel times between the two stations are negligible and that each server can only work on one customer at a time. We model the system as a birth–death Markov process, derive a closed form solution for the stationary distribution, and quantify the maximal asymptotic normalized throughput as the number of servers grows to infinity. We show that flexibility is more favorable for small systems, and as the number of servers grows, the benefits of flexibility decrease. Furthermore, we prove that when the number of servers goes to infinity, there is no need of flexibility at all, as the maximum value of the throughput is obtained. However, flexibility still has a secondary beneficial effect — a little flexibility (on the order of the square root of the number of dedicated servers at each station) guarantees that all dedicated servers are busy and results in faster convergence to the maximum throughput.
Early life in Edinburgh and beyond: 1835–55
Authors: Cribb Stephen J. 
Published: September 2018

Abstract
Archibald Geikie was born on 28 December 1835 into a middle class professional family from central Edinburgh, whose principal business for at least four generations had been hairdressing. This paper looks at the life and times of an academic young boy and charts his early years and the factors that helped him to develop. He was clearly driven and certainly had an eye for the best chance. Persevering through bouts of serious illness and family monetary problems in his teenage years, he undertook several geological excursions, published reports and secured introductions to many of the significant natural scientists living in Edinburgh at the time. With the help of these contacts, and shrugging off the difficulties that appeared in his path, he achieved by the age of 20 the first step towards his chosen profession and became a geologist with the newly established Geological Survey of Scotland.
The Predictive Value of the Hydrogen Breath Test in the Diagnosis of Fructose Malabsorption
Authors: Helwig Ulf , Koch Anna K. , Koppka Nadine , Holtmann Sylvia , Langhorst Jost 
Published: September 2018

Background: Fructose malabsorption is commonly diagnosed by the hydrogen fructose (H2) breath test. However, the mechanisms behind fructose malabsorption in humans are not well understood and the clinical relevance of this test is considered controversial. Hence, the main aim of this study is to evaluate the predictive value of the H2 breath test. Methods: Regarding exclusion criteria, the study enrolled 562 consecutive patients, enlisted to a gastroenterology clinic between 2009 and 2011 for testing malabsorption. In the final data analysis, 246 patients were included. Ecotrophologists used 3 categories to rate dietary success: complete response, partial response and no response to the diet. They also rated the occurrence of abdominal pain, diarrhoea and bloating during the H2 breath test. Ordinal regression analysis using SPSS was performed to evaluate whether H2 breath test results – measured as the maximum H2 level, the maximum increase in H2, and the area under the curve (AUC) – predicted dietary success or failure. Correlation analyses were applied to test whether symptoms of fructose malabsorption correlated with the H2 breath test measures. Finally, we evaluated whether cut-off-values of 40 or 60 parts per million (ppm) serve better than the test measure of 20 ppm to diagnose fructose malabsorption. Results: When a fructose-free diet was administered it was found that 103 patients (41.9%) were complete responders, 116 (47.2%) were partial responders and 27 (11%) were non-responders. The H2 breath test with the 20 ppm cut-off-value, that is, the maximum H2 level, the maximum increase in H2, and the AUC did not predict dietary response (all 95% CI ns). This was also the case when using 40 or 60 ppm as cut-off-values (all 95% CI ns). Abdominal pain during the test correlated significantly with the AUC. Diarrhoea and bloating correlated significantly with the AUC, the maximum H2 level and the maximum increase in H2 (p < 0.05). Conclusions: The H2 breath test produced no predictive value for the fructose-free diet outcomes; its value as a predictive test is therefore questionable. However, the symptoms of fructose malabsorption correlated significantly with the H2 breath test measures, and this is an indication that there is at least a degree of validity of the H2 breath test beyond the simple detection or exclusion of fructose malabsorption.
Sleep Disturbance and Its Association with Gastrointestinal Symptoms/Diseases and Psychological Comorbidity
Authors: Lei Wei-Yi , Chang Wei-Chuan , Wong Ming-Wun , Hung Jui-Sheng , Wen Shu-Hui , Yi Chih-Hsun , Liu Tso-Tsai , Chen Jiann-Hwa , Hsu Ching-Sheng , Hsieh Tsung-Cheng , Chen Chien-Lin 
Published: September 2018

<b><i>Background/Aims:</i></b> We aimed to investigate gastrointestinal symptoms, clinical characteristics, and psychological factors in subjects with and without sleep disturbance (SD) in a health screening cohort. <b><i>Methods:</i></b> We enrolled 2,752 consecutive subjects during their health checkups. All participants underwent an evaluation with questionnaires. Demographic characteristics and biochemical data were recorded. SD was confirmed when Pittsburgh Sleep Quality Index score was greater than 5. <b><i>Results:</i></b> Among the study population (<i>n</i> = 2,674), 956 (36%) individuals had SD. SD was associated with female gender, older age, lower level of education, higher systolic blood pressure, higher serum high-density lipoprotein levels and higher prevalence of functional dyspepsia and irritable bowel syndrome (IBS). SD subjects also had more depression, more anxiety, more severe gastrointestinal reflux disease symptoms and higher prevalence of non-erosive reflux disease (NERD; <i>p</i> &#x3c; 0.001). SD was ­independently associated with female gender (OR 1.75, <i>p </i>&#x3c; 0.001), older age (OR 1.03, <i>p</i> &#x3c; 0.001), NERD (OR 1.88, <i>p</i> = 0.004), IBS (OR 1.51, <i>p</i> = 0.043), and depression (OR 1.16, <i>p</i> &#x3c; 0.001) by multivariate analysis. <b><i>Conclusions:</i></b> Future studies will be needed to clarify the interrelationships among SD, psychological stress, and functional gastrointestinal disorders.