bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Tolerability of Letetresgene Autoleucel (GSK3377794): Pilot Studies in Patients with Advanced Non–Small Cell Lung Cancer
Authors: Altan Mehmet , Lopes Gilberto , Hiltermann T. Jeroen N. , Govindan Ramaswamy , Villaruz Liza C. , Calvo Emiliano , Edelman Martin J. , Furqan Muhammad , Neal Joel , Felip Enriqueta , Carlisle Jennifer W. , Heymach John V. , O’Cearbhaill Róisín Eilish , Zauderer Marjorie , Chisamore Michael , Corigliano Ellie , Eleftheriadou Ioanna , Zajic Stefan , Jenkins Ben , Goodison Sophia , Suchindran Sunil , Ramos-Hernandez Natalia , Tarek Nidale , Schoenfeld Adam J. 
Published: November 2024

Abstract

Purpose:
The study aims to evaluate the safety, tolerability, and antitumor response of letetresgene autoleucel (lete-cel), genetically modified autologous T cells expressing a T-cell receptor specific for New York esophageal squamous cell carcinoma 1 (NY-ESO-1)/LAGE-1a shared epitope, alone or in combination with pembrolizumab, in HLA-A*02–positive (HLA-A*02:01, HLA-A*02:05, and/or HLA-A*02:06) patients with NY-ESO-1– and/or LAGE-1a–positive non–small cell lung cancer.

Patients and Methods:
Study 208749 was a single-arm study of lete-cel alone. Study 208471 was a multiarm study of lete-cel alone or in combination with pembrolizumab in patients with advanced or recurrent non–small cell lung cancer.

Results:
More than 2,500 patients were screened for target expression. In the multiarm study, 738 (45%) of 1,638 tested patients were HLA-A*02–positive. NY-ESO-1 and LAGE-1a testing was positive in 12% (62/525) and 4% (15/348) of tested patients, respectively. Forty-one patients positive for HLA-A*02 and antigen expression were screened in the single-arm study. Overall, 43 patients underwent leukapheresis and 18 received lete-cel across studies. Lete-cel demonstrated a manageable safety profile. No fatal treatment-related serious adverse events (AE) were reported in either study. Cytopenias and cytokine release syndrome were the most common treatment-emergent AEs. Combining pembrolizumab with lete-cel did not seem to increase toxicity over lete-cel alone. Limited antitumor activity was observed; one of 18 patients had a durable response persisting for 18 months. Pharmacokinetic data showed similar T-cell expansion in all patients.

Conclusions:
Extensive HLA-A*02 and antigen expression testing was performed to identify potential participants. Lete-cel was generally well tolerated and had no unexpected AEs. Antitumor activity was observed in a limited number of patients.
A Phase II Open-Label, Randomized Clinical Trial of Atezolizumab with or without Human Recombinant IL-7 (CYT107) in Advanced Urothelial Cancer
Authors: Sweis Randy F. , Chatta Gurkamal S. , Jain Rohit K. , Moon Helen , Delacroix Scott Edward , Fang Alana , D’Amico Leonard , Kask Angela Shaulov , Cheever Martin A. , Fling Steven , Sharon Elad , Lacroix Andreanne , Kaiser Judith C. , Pachynski Russell K. , Yu Evan Y. 
Published: November 2024

Abstract

Purpose:
Advanced urothelial cancer generally has high mortality despite modern anti–PD-1/L1 antibody–based combinations. Augmenting checkpoint inhibitor–mediated immune responses with lymphocyte growth factors may improve outcomes. We conducted a randomized phase II study (Cancer Immunotherapy Trials Network-14) in 47 patients to explore whether human recombinant IL-7 (CYT107) could be safely combined with PD-L1 inhibition to enhance responses.

Patients and Methods:
Patients with urothelial cancer after platinum chemotherapy were randomized to atezolizumab alone or with CYT107 weekly for four doses. The primary objective was clinical efficacy by the objective response rate (ORR). Secondary objectives included safety, toxicity, and other clinical outcomes. Correlative endpoints included peripheral immunophenotyping and quantification of cytokines.

Results:
CYT107 plus atezolizumab was well-tolerated, without dose-limiting toxicities and lower grade 3 to 4 treatment-related adverse events compared with atezolizumab monotherapy. The ORR was 26.3% for the combination therapy versus 23.8% for atezolizumab alone (P = 0.428). The complete response rate was 10.5% for the combination therapy versus 4.8% for monotherapy. Three patients on combination therapy had responses &gt;21 months versus one with monotherapy. CD4+ and CD8+ T-lymphocyte expansion occurred in patients with response to combination therapy, with the greatest effect in T memory stem cells. Patients who responded to treatment exhibited elevated baseline levels of CCL4 and reduced levels of VEGFA and TNF.

Conclusions:
Combining CYT107 with atezolizumab was safe and resulted in lymphocyte expansion, a doubling of the complete response rate, and durable responses exceeding 2 years. However, the ORR was similar to atezolizumab alone. Increased and sustained doses of CYT107 coupled with patient selection strategies should be further investigated.
Drug‐Coated Balloons Versus Drug‐Eluting Stents or Plain Old Balloon Angioplasty: A Long‐Term in‐Stent Restenosis Study
Authors: von Koch Sacharias , Zhou Mikael , Rosén Hans Christian , Zwackman Sammy , Jurga Juliane , Grimfjärd Per , Götberg Matthias , Mohammad Moman A. , Erlinge David 
Published: November 2024

Background
Balloon angioplasty with drug‐coated balloons (DCBs) is frequently used during percutaneous coronary intervention for in‐stent restenosis. Despite its frequent use, there is a lack of long‐term data on the efficacy of DCB angioplasty. We conducted an investigation on the long‐term efficacy outcome of in‐stent restenosis, comparing DCBs, drug‐eluting stents, and plain old balloon angioplasty.

Methods and Results
We conducted a nationwide analysis from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry) including in‐stent restenosis lesions undergoing coronary angiography between June 11, 2013, and January 14, 2022. The primary outcome of this study was target‐lesion revascularization within a 5‐year follow‐up. Secondary outcomes included all‐cause death, cardiovascular death, myocardial infarction, and any percutaneous coronary intervention. The outcomes were analyzed using a multivariable Cox proportional hazard model or Poisson regression, as appropriate. A total of 10 561 lesions from 9062 patients were included. Compared with plain old balloon angioplasty, the use of DCB angioplasty was associated with less target‐lesion revascularization (risk ratio, 0.69 [95% CI, 0.57–0.82]), all‐cause death (risk ratio, 0.72 [95% CI, 0.59–0.88]), and cardiovascular death (hazard ratio [HR], 0.59 [95% CI, 0.45–0.78]). No difference was observed for myocardial infarction or any percutaneous coronary intervention. Compared with drug‐eluting stents, the use of DCBs was associated with higher rates of target‐lesion revascularization (HR, 1.20 [95% CI, 1.06–1.37]). No difference was observed for all‐cause death, cardiovascular death, myocardial infarction, or any percutaneous coronary intervention.

Conclusions
In this long‐term nationwide analysis, the use of DCB angioplasty showed superior outcomes compared with plain old balloon angioplasty within 5 years but higher rates of repeat revascularizations compared with drug‐eluting stents.
Exploring the Spiritual and Functional Aspects of Sacred Groves
Authors: Asante Daniel Boamah 
Published: November 2024

Abstract
This study delves into the multifaceted nature of sacred groves within the Kwahu Traditional Area of Ghana, specifically focusing on the Kwaékese and Twendurase Mystical Sacred Groves. These groves represent unique community-conserved areas, intertwined with both spiritual and utilitarian motives. Simultaneously, the study delves into their ecological role in safeguarding perennial water sources and as repositories for endangered flora and fauna, preserving biodiversity in the face of expanding human activities. Furthermore, the research highlights the evolving role of sacred groves in response to contemporary challenges, such as population growth and deforestation. This study underscores the coexistence of spirituality and practicality in these unique ecosystems, shedding light on the multifaceted nature of sacred groves and their indispensable ecological significance.
“It Is Taboo to Clear Those Forests or Cut Trees from Them”
Authors: Nche George C. , Michael Benson Ogar 
Published: November 2024

Abstract
The preservation of sacred forests holds significant implications for environmental sustainability, yet mainstream conservation frameworks often overlook the integration of indigenous knowledge and religious practices. This study explored the preservation of sacred forests among the Abanyom people in Cross River State, Nigeria, and its implications for environmental sustainability. Data was elicited through semi-structured interviews with 15 participants comprising traditional leaders (n=12), clan heads (n=2), and chief priests (n=1), originating from Abanyom’s constituent clans—Abanyom (n=8) and Abangork (n=7). Through an investigation into the number, nature, taboos, rituals, and rationale behind the preservation of the sacred forests, the study highlighted the multifaceted significance of these forests to local communities. Findings revealed that the preservation of sacred forests is deeply rooted in cultural practices and serve as repositories of ecological, cultural, and spiritual value. The study emphasized the importance of integrating traditional ecological knowledge into modern conservation strategies. This includes promoting intergenerational knowledge transfer and fostering community stewardship to ensure the long-term protection of sacred forests.
Needfulness and the Knowledge of God in Barth’s Dogmatics
Authors: Dorman David A. 
Published: November 2024

Abstract
In the opening of CD II/1, Barth expounds his theological epistemology anchored in the grace of God and (thereby) the concomitant readiness of humanity for grace. In doing so he propounds a “Christian anthropology” of “blessed radical needfulness” that explicates God’s creational intention for humanity, the turn of humanity to sin, and humanity’s redemption in Jesus Christ. Although the significance of this positive anthropological proposal has suffered in critical discussion, a renewed look at its function discloses it to be decisive for Barth’s understanding of how we as humans know God and how we understand ourselves and/or salvation.
Obedience, Punishment, and Merit
Authors: van den Brink Gert 
Published: November 2024

Abstract
There is a longstanding debate on whether the Heidelberg Catechism favors the imputation of the active obedience of Christ (IAOC). In this article, I argue that the IAOC is not present in the Catechism, not even latently. The main authors of the Catechism, Olevianus and Ursinus, denied the IAOC. Additionally, what the Catechism teaches about the interrelations between obedience, punishment and merit, makes clear that the IAOC does not fit in its theological structure. Therefore, a historically sensitive interpretation of the Catechism leads to the recognition that the Catechism leaves no room for the IAOC.
Christology from Within
Authors: Atansi Chukwuemeka Anthony 
Published: November 2024

Abstract
This article explores the place and framework for a socially transformative Christology, particularly in Africa. More specifically, it calls attention to the importance of grassroots christological imagination in the discussion of the social relevance of faith in Jesus Christ in Africa. The essay begins with highlighting the marginalization of the christological narratives of Christians at the grassroots still present in some of the academic discussions about the meaning and social significance of Christ in African Christianity. It then argues that taking seriously the grassroots Christologies, and a more critical-empathetic engagement of them within the framework of imagination and image, open up an effective way of doing Christology ‘from within’ the proclamation and longing of the People of God, who are graced to become both the embodiment and agents of Christ’s transforming presence and act. To this end, the article attempts to trace something of the mutual illumination connecting Christology and the transformation of society in Africa. And in doing so, it contributes to the task of bridging the gap that often exists between popular and academic Christologies.
Gospel of Jealousy
Authors: Wynne Jeremy J. 
Published: November 2024

Abstract
This essay argues for a more substantive account of the God whose “name is Jealous” (Exod. 34:14), over and against both cultural resistance and theological ambivalence to jealousy as a positive feature of the divine-human relationship. Attention to Reformed priorities in a responsible reading of scripture is followed by a theology of the proper context, focus, and goal of jealousy itself. The results are twofold: a biblical proposal for this affection as a form of God’s redeeming holiness and, by extension, validation of our own jealousy as protest against multiple forms of bad faith.
Homeric Formulae
Authors: Finkelberg Margalit 
Published: November 2024

Abstract
This article discusses the issue of applicability of Milman Parry’s principles of economy and extension to Homer and other epic traditions. By addressing the objections raised by scholars in various fields, it argues that the presence of formulae is in itself not enough for either proving or disproving a given text’s orality. Only economy and extension embodied in the systems of formulae can serve as such a proof. Application of this criterion to various epic traditions shows that, although economy and extension cannot be considered universal indices of orality, they do fulfil this function in Homer and early Greek epic.
Homer and the Cyclic Thebais
Authors: Tsagalis Christos C. 
Published: November 2024

Abstract
This article discusses several cases of phraseology shared by the Homeric epics and the Cyclic Thebais and explores three techniques (synergetic shaping, the interplay between analogy and difference, and metaphrasis) used for the construction of meaning. The diction employed by a post-Homeric epic such as the Thebais indicates that several individual expressions acquire an interpretive surplus when examined against the backdrop of the system of archaic Greek epic, a fundamental component of which is Homeric epic.
Initiation of Hearing Aids Use and Incident Dementia Among Mid-to-late Life Adults: The Health and Retirement Study 2010-2018
Authors: Wei Jingkai , Li Kun , Kim Youngran , Ghosal Rahul , Zhang Donglan , Merchant Anwar T. , Crump Casey 
Published: November 2024

Background and Objectives Hearing aids may reduce the risk of dementia among individuals with hearing loss. However, no evidence is available from randomized controlled trials (RCTs) on the effectiveness of hearing aids use in reducing incident dementia. Using target trial emulation, we leveraged an existing longitudinal cohort study to estimate the association between hearing aids initiation and risk of dementia. Research Design and Methods The Health and Retirement Study was used to emulate target trials among non-institutionalized participants aged ≥50 years with self-reported hearing loss, without dementia at baseline, and without use of hearing aids in the previous 2 years. Intention-to-treat analysis was conducted to estimate the risk of dementia associated with hearing aids initiation vs controls who did not initiate hearing aids. Pooled logistic regression models with inverse-probability of treatment and censoring weights were applied to estimate risk ratios, and 95% confidence intervals were calculated using 1000 sets of bootstrapping. Results Among 2314 participants (328 in the intervention group and 1986 in the control group; average age: 72.3 ± 9.7 years, 49% women, and 81% White), after 8 years of follow-up, risk of dementia was significantly lower among individuals who initiated hearing aids (risk difference (RD): −0.05, 95% confidence interval (CI): −0.08, −0.01). A lower risk was observed particularly among adults aged 50-74 years, men, and individuals with cardiovascular disease. Discussion and Implications Hearing aids use was associated with a significant reduction of incident dementia. Future interventional studies are needed to further assess the effectiveness of hearing aids in preventing dementia.
Development of an Artificial Intelligence-Based Algorithm for the Assessment of Skeletal Age and Detection of Cervical Vertebral Anomalies in Patients with Cleft Lip and Palate
Authors: Kamei Gaithoiliu , Batra Puneet , Singh Ashish Kumar , Arora Garima , Kaushik Simran 
Published: November 2024

To develop an artificial intelligence (AI)-based algorithm for the assessment and comparison of skeletal maturation in patients with and without cleft lip and/or palate and to detect the presence of cervical vertebral anomalies (CVAs). Retrospective cohort study. A university orthodontic clinic and comprehensive cleft care centers. In total, 1080 cephalograms of patients with and without unilateral cleft lip and palate (UCLP) aged 6 to 18 years, without any associated syndromes, congenital disorders, or history of trauma or illness, were collected. About 960 cephalograms were assessed in the study upon elimination of poor-quality lateral cephalograms. The MobileNet architecture using TensorFlow framework was employed to develop 2 convolutional neural network (CNN)-based AI models for automated assessment of skeletal age and detection of CVAs. Inter-rater reliability for manual cervical vertebral maturation (CVM) staging was assessed using Cohen's kappa coefficient, and intraclass correlation coefficient (ICC) was calculated. The results of each model were separately analyzed using chi-square test, and the statistical significance was tested at 5% level. The CNN-based AI model yielded an average accuracy rate of 74.5%, with an accuracy of up to 88% for detecting skeletal maturity and an accuracy rate of 83% for detecting CVAs. It can be concluded that CVM methods help detect skeletal maturity objectively in patients with UCLP and have shown delayed skeletal growth compared to patients without UCLP. CVAs were found to be more prevalent in patients with UCLP than in their non-cleft counterparts, with these findings facilitated by utilizing a novel AI algorithm.
Analysis of green belt designs in mitigating anthropogenic heat emission from buildings by considering cooling efficiency and nurture costs
Authors: Cui Yongbo , Fan Chengliang , Zhou Xiaoqing , Liao Yundan 
Published: November 2024

Building anthropogenic heat emission is one of the key factors contributing to both building thermal environment and urban heat island, which can potentially lead to increasement of building energy consumption and carbon emission. Mitigating this heat through green belts is an effective solution to achieving low carbon development in buildings. Therefore, this study analyzed the impact of the location and type of green belts around buildings on the thermal environment around buildings. A co-benefit assessment model was developed to quantify green belt design parameters based on the identification of optimal green belt types and locations. Results showed the building thermal environment was significantly influenced by anthropogenic heat emission, leading to a maximum increase of 3.4°C in air temperature. Compared with buildings without green belts, the optimal green belt design (i.e. lawns, shrubs and trees configuration) could decrease the temperature around the building by 1.85°C, while the cooling efficiency reached 47.20%. The optimal lawn area distance was determined to be 0.5 S (S is the building’s footprint), the optimal shrub length was found at 0.6 L to 0.8 L (L is the length of the building), while the optimal tree spacing distance was determined to be 3.5 m to 4.0 m in this study.
Evaluating the effectiveness of LINE-based health interventions on dietary habits and health perceptions among young women: A pilot randomized controlled trial
Authors: Ohtsuki Makoto , Komada Ai , Okada Hiromi , Furuta Kanako , Aikawa Yuki , Umehara Yoriko 
Published: November 2024

Objective This study aimed to investigate the potential of LINE, a major messaging app and social media platform in Japan, as an effective tool to enhance the health and dietary behaviors of young Japanese women who face health and dietary challenges. Methods A 6-week randomized controlled trial employing an intention-to-treat analysis was conducted on first-year female students (age range, 18–23 years) from one university and two junior colleges in Mie Prefecture. The participants were allocated to either an intervention group (n = 54) or a control (n = 55) group. The intervention group received health information focusing on proper intake and intake methods to maintain an appropriate weight and dietary balance via LINE 18 times over 6 weeks (3 times per week), whereas the control group continued their usual lifestyle without any additional intervention. Results The results revealed a significant increase in the percentage of participants in the intervention group who rated their health as “unhealthy” (from 25.9% to 40.3%). This may be attributed to increased health awareness among the participants, which led to more critical self-assessments—a phenomenon often referred to as the “health awareness paradox.” Despite this increase in perceived unhealthiness, the intervention group showed a significant increase in the intakes of iron, vitamin C, dietary fiber, and potassium, indicating improved nutritional behavior. Conclusion The provision of health information through LINE over a 6-week period demonstrated potential as a tool for health education among young Japanese women. However, the observed increase in “unhealthy” self-rated health underscores the complexity of such interventions, suggesting that while nutritional behavior may improve, increased health awareness can paradoxically lead to more negative self-assessments. Further research is needed to explore the optimal duration and content of health information delivered via social media apps to maximize their effectiveness for health interventions.