bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus
Authors: Jayawardena Nadishka , Burga Laura N. , Easingwood Richard A. , Takizawa Yoshimasa , Wolf Matthias , Bostina Mihnea 
Published: October 2018

Significance
Anthrax toxin receptor 1 (ANTXR1), also known as Tumor Endothelial Marker 8, is overexpressed on the surface of tumor cells in over 60% of human cancers. A serious drawback for developing specific ligands for targeted therapy against ANTXR1 is the cross-reactivity with ANTXR2. Recently, ANTXR1 was identified as the high-affinity cellular receptor for Seneca Valley Virus (SVV). SVV has shown promising results as an oncolytic agent in clinical trials, and this discovery offers a powerful biomarker for selecting patient response to treatment. The identification of specific interaction sites between SVV and ANTXR1 lays the foundation to construct potent virus mutants with specific cancer tropism that can escape host antibody response and to expand the development of both antiangiogenic and anticancer antibody therapy.
Fansubbing in subtitling land
Authors: Pedersen Jan 
Published: October 2018

AbstractFansubs (subtitles made by fans for fans) have become a global practice, and it is by now a fairly well-described phenomenon, particularly for fansubs of Japaneseanime. However, for Sweden, which has a long and strong tradition of prosubs (commissioned professional subtitles), there have hardly been any studies of this increasingly prolific phenomenon. This paper seeks to remedy this situation by investigating 16 subtitled versions of ten English-language films. The analysis uses the FAR model of quality assessment and also investigates other aspects, such as creativity. The results show that there is great variety between the various fansubbed versions. On average, Swedish fansubs are found to be of lower quality, less adhering to norms and also more abusively faithful than prosubs. Moreover, the fansubs in this study are hardly creative at all. This could be due to fansubbing being a rather marginal phenomenon in Sweden, the land of subtitling.
Oculomotor dynamics in skilled soccer players: The effects of sport expertise and strenuous physical effort
Authors: Zwierko Teresa , Jedziniak Wojciech , Florkiewicz Beata , Stępiński Miłosz , Buryta Rafał , Kostrzewa‐Nowak Dorota , Nowak Robert , Popowczak Marek , Woźniak Jarosław 
Published: October 2018

AbstractThe ability to quickly locate objects within the visual field has a significant influence on athletic performance. Saccades are conjugate eye movements responsible for the rapid shift that brings a new part of the visual field into foveal vision. The aim of this study was to investigate the effects of sport expertise and intense physical effort on saccade dynamics during a free‐viewing visual search task in skilled soccer players. Two groups of male subjects participated in this study: 18 soccer players and 18 non‐athletes as the control group. Two sessions of visual search tasks without a sport‐specific design were employed. Eye movements during the visual search tasks were recorded binocularly. Between pre‐ and post‐test sessions, athletes performed a maximal incremental treadmill test. Cardiorespiratory parameters were measured continuously. Capillary lactate samples were collected. Pre‐test findings indicated that athletes, in comparison to non‐athletes, achieve higher values of the following characteristics of saccades (1) average acceleration, (2) acceleration peak, (3) deceleration peak, and (4) average velocity. An increase in post‐test saccade duration and a decrease in post‐test saccade velocity was observed in athletes due to the strenuous physical effort in relation to the pre‐test state. Athletes may transfer high saccadic function efficiency to non‐specific visual stimuli. The findings partially confirm that physical exertion can reduce oculomotor efficiency in athletes.
Synthesis and crystal structure of dinuclear based coordination polymer derived from N-6-[(4-pyridylmethylamino)carbonyl]-2-pyridinecarboxylic acid methyl ester
Authors: Kadir M A , Mansor S M T , Mehamod F S , Yusof M S M 
Published: October 2018

Abstract
This study describes the facile synthesis and crystal structure of one dimensional coordination polymer which has been successfully obtained from reaction between semi rigid monoamide ligand namel N6-[(4-pyridylmethylamino)carbonyl]-2-pyridinecarboxylic acid methyl ester (L2) with copper perchlorate. The synthesized coordination polymer, with formula given by elemental analysis and X-ray crystallography as {[Cu3(L2-CH3)3(L2)2(H2O)2(CH3OH)](ClO4)3}n was crystallized in monoclinic crystal system and space group C2/c. The asymmetric unit of this complex consists of three copper atoms, three anionic carboxylate forms of ligand L2, two neutral forms of ligand L2 and four partially-occupied non-coordinated perchlorate anions. This asymmetric unit acts as the repeating fragment to form one-dimensional networks which was stabilized by intramolecular hydrogen bonds.
SJARACNe: a scalable software tool for gene network reverse engineering from big data
Authors: Khatamian Alireza , Paull Evan O , Califano Andrea , Yu Jiyang 
Published: October 2018

Abstract

Summary
Over the last two decades, we have observed an exponential increase in the number of generated array or sequencing-based transcriptomic profiles. Reverse engineering of biological networks from high-throughput gene expression profiles has been one of the grand challenges in systems biology. The Algorithm for the Reconstruction of Accurate Cellular Networks (ARACNe) represents one of the most effective and widely-used tools to address this challenge. However, existing ARACNe implementations do not efficiently process big input data with thousands of samples. Here we present an improved implementation of the algorithm, SJARACNe, to solve this big data problem, based on sophisticated software engineering. The new scalable SJARACNe package achieves a dramatic improvement in computational performance in both time and memory usage and implements new features while preserving the network inference accuracy of the original algorithm. Given that large-sampled transcriptomic data is increasingly available and ARACNe is extremely demanding for network reconstruction, the scalable SJARACNe will allow even researchers with modest computational resources to efficiently construct complex regulatory and signaling networks from thousands of gene expression profiles.

Availability and implementation
SJARACNe is implemented in C++ (computational core) and Python (pipelining scripting wrapper, ≥3.6.1). It is freely available at https://github.com/jyyulab/SJARACNe.

Supplementary information
Supplementary data are available at Bioinformatics online.
Obstacle Negotiation, Gait Variability, and Risk of Falling: Results From the “Gait and Brain Study”
Authors: Pieruccini-Faria Frederico , Montero-Odasso Manuel 
Published: October 2018

Abstract

Background
Gait variability is an early fall predictor. However, it is unknown how gait variability of older adults at high risk of falls is affected by an obstacle negotiation task. We aimed to compare gait performance between older adults with significant history of falls (i.e. fallers) and nonfallers while approaching an obstacle crossing.

Methods
A total of 137 older adults without dementia were enrolled (72.7 ± 5.1 years of age; 60.5% women) from the “Gait and Brain Study.” Fallers were defined as having at least one injurious fall or at least two noninjurious falls in the previous 12 months. Participants performed gait assessments under unobstructed and obstructed conditions. During the obstructed condition, participants walked and stepped over an ad hoc obstacle set at 15% of participants’ height, transversally placed on a 6-meter electronic walkway. Gait speed and step-to-step variabilities were quantified from the last six steps prior to obstacle crossing. Analysis of variance models adjusted for age, sex, fear of falling, comorbidities, and unobstructed gait were used to compare gait performance of fallers and nonfallers during an obstacle approaching.

Results
In the study, 27 older adults were identified as fallers and 110 as nonfallers. Fallers had higher step time variability and step length variability when approaching an obstacle compared with nonfallers, although groups had comparable gait performance during unobstructed walking.

Conclusion
Gait variability of older individuals at high risk of falling is more disturbed, compared with low-risk individuals, while approaching an obstacle crossing. High gait variability prior to crossing an obstacle may be a risk factor for falls.
Maturing satellite kinematics into a competitive probe of the galaxy–halo
connection
Authors: Lange Johannes U , van den Bosch Frank C , Zentner Andrew R , Wang Kuan , Villarreal Antonia Sierra 
Published: October 2018

ABSTRACT
The kinematics of satellite galaxies moving in a dark matter halo are a direct probe of the underlying gravitational potential. Thus, the phase-space distributions of satellites represent a powerful tool to determine the galaxy–halo connection from observations. By stacking the signal of a large number of satellite galaxies this potential can be unlocked even for haloes hosting a few satellites on average. In this work, we test the impact of various modelling assumptions on constraints derived from analysing satellite phase-space distributions in the non-linear, one-halo regime. We discuss their potential to explain the discrepancy between average halo masses derived from satellite kinematics and gravitational lensing previously reported. Furthermore, we develop an updated, more robust analysis to extract constraints on the galaxy–halo relation from satellite properties in spectroscopic galaxy surveys such as the SDSS. We test the accuracy of this approach using a large number of realistic mock catalogues. Furthermore, we find that constraints derived from such an analysis are complementary and competitive with respect to the commonly used galaxy clustering and galaxy–galaxy lensing observables.
The wide binary fraction of solar-type stars: emergence of metallicity dependence at a &lt; 200 au
Authors: El-Badry Kareem , Rix Hans-Walter 
Published: October 2018

ABSTRACT
We combine a catalogue of wide binaries constructed from Gaia DR2 with [Fe/H] abundances from wide-field spectroscopic surveys to quantify how the binary fraction varies with metallicity over separations 50 ≲ s/au ≲ 50 000. At a given distance, the completeness of the catalogue is independent of metallicity, making it straightforward to constrain intrinsic variation with [Fe/H]. The wide binary fraction is basically constant with [Fe/H] at large separations (s ≳ 250 au) but becomes quite rapidly anticorrelated with [Fe/H] at smaller separations: for 50 &lt; s/au &lt; 100, the binary fraction at $\rm [Fe/H] = -1$ exceeds that at $\rm [Fe/H] = 0.5$ by a factor of 3, an anticorrelation almost as strong as that found for close binaries with a &lt; 10 au. Interpreted in terms of models where disc fragmentation is more efficient at low [Fe/H], our results suggest that 100 &lt; a/au &lt; 200 is the separation below which a significant fraction of binaries formed via fragmentation of individual gravitationally unstable discs rather than through turbulent core fragmentation. We provide a public catalogue of 8407 binaries within 200 pc with spectroscopically determined [Fe/H] for at least one component.
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Steroids in the Treatment of Adults With Metastatic Brain Tumors
Authors: Ryken Timothy C , Kuo John S , Prabhu Roshan S , Sherman Jonathan H , Kalkanis Steven N , Olson Jeffrey J 
Published: October 2018

Abstract

QUESTION
Do steroids improve neurological symptoms and/or quality of life in patients with metastatic brain tumors compared to supportive care only or other treatment options? If steroids are given, what dose should be used?

TARGET POPULATION
These recommendations apply to adults diagnosed with brain metastases.

RECOMMENDATIONS

STEROID THERAPY VERSUS NO STEROID THERAPY

Asymptomatic brain metastases patients without mass effect
Insufficient evidence exists to make a treatment recommendation for this clinical scenario.
Brain metastases patients with mild symptoms related to mass effect

Level 3: Corticosteroids are recommended to provide temporary symptomatic relief of symptoms related to increased intracranial pressure and edema secondary to brain metastases. It is recommended for patients who are symptomatic from metastatic disease to the brain that a starting dose of 4 to 8 mg/d of dexamethasone be considered.
Brain metastases patients with moderate to severe symptoms related to mass effect

Level 3: Corticosteroids are recommended to provide temporary symptomatic relief of symptoms related to increased intracranial pressure and edema secondary to brain metastases. If patients exhibit severe symptoms consistent with increased intracranial pressure, it is recommended that higher doses such as 16 mg/d or more be considered.

CHOICE OF STEROID

Level 3: If corticosteroids are given, dexamethasone is the best drug choice given the available evidence.
Duration of Corticosteroid Administration

Level 3: Corticosteroids, if given, should be tapered as rapidly as possible but no faster than clinically tolerated, based upon an individualized treatment regimen and a full understanding of the long-term sequelae of corticosteroid therapy.
Given the very limited number of studies (2) which met the eligibility criteria for the systematic review, these are the only recommendations that can be offered based on this methodology.
The full guideline can be found at https://www.cns.org/guidelines/guidelines-treatment-adults-metastatic-brain-tumors/chapter_7.
Stunting, dietary diversity and household food insecurity among children under 5 years in ethnic communities of northern Thailand
Authors: Roesler Anna L , Smithers Lisa G , Wangpakapattanawong Prasit , Moore Vivienne 
Published: October 2018

ABSTRACT

Background
The aim of this study was to describe stunting in infants and young children in the ethnic communities of northern Thailand and to explore associations with dietary diversity and household factors including food security.

Methods
A cross-sectional survey of households with children under 5 years from eight villages. Adult respondents provided information on foods consumed by each child and details of the household. Heights and weights of children were measured.

Results
Adults from 172 households and 208 children participated. Overall, 38% of children were stunted. Exclusive breastfeeding was rare, but the proportion consuming breastmilk at 24 months (75%) was high. Few children (7%) aged 6–11 months met minimum dietary diversity. Stunted children were less likely than non-stunted children to meet minimum dietary diversity (63 versus 82%). Widespread food insecurity did not discriminate between stunted and non-stunted children. Stunting was elevated when households had little land and few animals.

Conclusions
Stunting was widespread in children under 5 years of age, in part reflecting poor dietary diversity, especially at age 6–11 months. Stunting was worst in households with least assets. Small increases in land or animals, or equivalent resources, appear to be required to improve child nutrition in extremely poor families.
MANIPULATION OF THE DOSE–RESPONSE OF COMPOSITE GLOW PEAK 5 IN THE THERMOLUMINESCENCE OF LiF:Mg,Ti (TLD-100) VIA OPTICAL EXCITATION POST-IRRADIATION: POTENTIAL FOR IMPROVED DOSE–RESPONSE LINEARITY BEYOND 1 Gy
Authors: Ginzburg D , Oster L , Eliyahu I , Reshes G , Biderman S , Horowitz Y S 
Published: October 2018

Abstract
Many dosimetric applications and especially those involved in clinical dosimetry are hampered by the supralinearity of TLD-100 which begins at a level of dose of 1 Gy. This research investigates the effect of optical excitation following irradiation on the dose–response. It is expected that this will lead to a more linear dose–response, however, irrespective of the hoped-for linearity, the theoretical/kinetic simulations of the effect of optical excitation will further enhance our understanding of the thermoluminescence mechanisms, especially the role of spatially correlated trapping and luminescent centers. In the following, the various stages carried out in these investigations are discussed and preliminary results presented.
Morbidity and Mortality Among Critically Injured Children With Acute Respiratory Distress Syndrome
Authors: Killien Elizabeth Y. , Mills Brianna , Watson R. Scott , Vavilala Monica S. , Rivara Frederick P. 
Published: October 2018

Objectives:
To evaluate morbidity and mortality among critically injured children with acute respiratory distress syndrome.

Design:
Retrospective cohort study.

Setting:
Four-hundred sixty Level I/II adult or pediatric trauma centers contributing to the National Trauma Data Bank.

Patients:
One hundred forty-six thousand fifty-eight patients less than 18 years old admitted to an ICU with traumatic injury from 2007 to 2016.

Interventions:
None.

Measurements and Main Results:
We assessed in-hospital mortality and need for postdischarge care among patients with and without acute respiratory distress syndrome and hospital resource utilization and discharge disposition among survivors. Analyses were adjusted for underlying mortality risk (age, Injury Severity Score, serious brain or chest injury, and admission heart rate and hypotension) and year, transfer status, and facility trauma level designation. Acute respiratory distress syndrome occurred in 2,590 patients (1.8%). Mortality was 20.0% among acute respiratory distress syndrome patients versus 4.3% among nonacute respiratory distress syndrome patients, with an adjusted relative risk of 1.76 (95% CI, 1.52–2.04). Postdischarge care was required in an additional 44.8% of acute respiratory distress syndrome patients versus 16.0% of patients without acute respiratory distress syndrome (adjusted relative risk, 3.59; 2.87–4.49), with only 35.1% of acute respiratory distress syndrome patients discharging to home versus 79.8% of patients without acute respiratory distress syndrome. Acute respiratory distress syndrome mortality did not change over the 10-year study period (adjusted relative risk, 1.01/yr; 0.96–1.06) nor did the proportion of acute respiratory distress syndrome patients requiring postdischarge care (adjusted relative risk, 1.04/yr; 0.97–1.11). Duration of ventilation, ICU stay, and hospital stay were all significantly longer among acute respiratory distress syndrome survivors. Tracheostomy placement occurred in 18.4% of acute respiratory distress syndrome survivors versus 2.1% of patients without acute respiratory distress syndrome (adjusted relative risk, 3.10; 2.59–3.70).

Conclusions:
Acute respiratory distress syndrome development following traumatic injury in children is associated with significantly increased risk of morbidity and mortality, even after adjustment for injury severity and hemodynamic abnormalities. Outcomes have not improved over the past decade, emphasizing the need for new therapeutic interventions, and prevention strategies for acute respiratory distress syndrome among severely injured children.
Evaluation of the efficacy and safety of elemene in treating malignant pleural effusion caused by tumors
Authors: Wang Qing-tao , Zhang Ze-lin , Xiong Hui , Zhou Dong-sheng , Li Jun , Liang Jian , Wang Ya-fei 
Published: October 2018

Abstract

Objective:
Elemene is widely used to treat malignant pleural effusion in China. This meta-analysis aimed to evaluate the efficacy and safety of elemene in treating malignant pleural effusion.

Methods:
Electronic databases including Pubmed, the Cochrane Library, Embase and Chinese biomedical literature database were searched until March 2017. Clinical controlled trials (CCTs) assessing the efficacy and safety of elemene in the treatment of malignant pleural effusion were included. The quality of the included studies was evaluated using the quality evaluation criteria of the Cochrane Handbook version 5.1.0.

Results:
A total of 46 CCTs were included, with 2992 patients. Results of meta-analysis showed that elemene significantly improved the overall response rate (ORR) in controlling malignant pleural effusion (risk ratio [RR] = 1.16; 95% CI: 1.08–1.23; P < .05). Subgroup results showed that the ORR of elemene in the treatment of lung cancer patients with malignant pleural effusion (RR = 1.20, 95% CI: 1.07–1.34; P < .05) was higher than that of other cancers (RR = 1.14, 95% CI: 1.05–1.23; P < .05). Meanwhile, elemene did not significantly increase the incidences of chest pain and fever (P > .05).

Conclusion:
Elemene is suggested to have the ability of improving the treatment outcome of malignant pleural effusion with acceptable safety.
Predicting the graft diameter of the peroneus longus tendon for anterior cruciate ligament reconstruction
Authors: Song Xiaoxiao , Li Qiangqiang , Wu Zongfang , Xu Qian , Chen Dongyang , Jiang Qing 
Published: October 2018

Abstract
The aim of this study was to evaluate the correlation between various anthropometric parameters and the graft diameter of the peroneus longus tendon (PLT).
We retrospectively analyzed the data of 156 patients who underwent anterior cruciate ligament reconstruction (ACLR) with the PLT graft at our institution. Anthropometric parameters, including height, weight, gender, age, duration of injury, and preinjury activity levels, were recorded. t tests, correlation coefficients (Pearson r), and a multiple linear regression analysis were used to evaluate the influence of these anthropometric variables on the diameter of the graft obtained.
The mean PLT graft diameter was 8.3 mm, and 21 patients (13.5%) had a diameter less than 8 mm; 85 patients (54.5%) had a diameter between 8 and 9 mm, and 50 patients (32.0%) had a diameter greater than or equal to 9 mm. The correlation analysis showed that height (P < .001), weight (P < .001), and duration of injury (P = .012) were significantly related to graft diameter. On the basis of these 3 predictors, the following regression equation was obtained: Diameter = 2.28 + 0.028∗height (cm) + 0.013∗weight (kg) + 0.289∗duration of injury (0 or 1). Patients who were short and shin were more likely to own smaller graft diameters (<8 mm), especially the one ruptured his or her anterior cruciate ligament (ACL) over 3 months.
Height, weight, and duration of injury were associated with the diameter of PLT. They are important preoperative information for surgeon about the size of PLT and can be used for alternative graft source planning and patient counseling.

Level of evidence: IV