bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐Cancer Effect of Sulforaphane in Human Pancreatic Cancer Cells Mia PaCa‐2
Authors: Park Min Ju , Kim Yoon Hee 
Published: December 2024

ABSTRACTBackgroundPancreatic cancer is difficult to treat early as it has no early symptoms. The presence of sulforaphane (SFN) in cruciferous vegetables has been found to possess anti‐cancer effects in gastric and colon cancers. Glycogen synthase kinase‐3 beta (GSK‐3β), a serine/threonine kinase, plays a significant role in pancreatic cancer progression, influencing tumor growth, metastasis, and treatment resistance. Targeting GSK‐3β has shown potential to enhance the efficacy of chemotherapy. However, the mechanism underlying the anticancer effects of SFN on pancreatic cancer through GSK‐3β is unclear.AimsIn this study, we examined the anticancer effects of SFN in human pancreatic cancer cell line Mia PaCa‐2 and evaluated its molecular mechanisms with respect to the GSK‐3β‐related pathway.Methods and ResultsSFN increased the protein expression of the phosphorylated form of GSK3β (Ser9). In the Wingless Int‐1 homolog/β‐catenin pathway, GSK3β induced apoptosis by phosphorylating β‐catenin. However, in mutant Kirsten rat sarcoma viral oncogene homolog‐like‐dependent cells such as Mia PaCa‐2, GSK3β was suppressed and the β‐catenin level was increased, thus inducing apoptosis. Indeed, SFN increased the protein expression of β‐catenin in the cytoplasm and nucleus. Subsequently, we measured the level of cMyc, the target gene of β‐catenin. SFN decreased cMyc expression despite an increase in the β‐catenin. We measured the expression of nuclear factor (NF)‐κB, a downstream factor of GSK3β and an upstream factor of cMyc. SFN decreased the expression of NF‐κB and cMyc, indicating that SFN inhibits cell proliferation by suppressing the GSK3β/NF‐κB/cMyc pathway. As the suppression of NF‐κB results in a decrease in B‐cell lymphoma 2 (BCL‐2) which is the anti‐apoptotic gene, we tested the effect of SFN in the expression of BCL‐2. SFN inhibited the expression of BCL‐2 and increased the ratio of the apoptotic regulator gene BCL‐2 associated X (BAX), where SFN induced the cleaved cysteine aspartase‐3 and poly‐adenosine diphosphate ribose polymerase.ConclusionThese results indicate that SFN may have therapeutic potential in the inhibition of pancreatic cancer.
Temperature Dependence of Thermal Conductivity of Proteins: Contributions of Thermal Expansion and Grüneisen Parameter
Authors: Leitner David M. 
Published: December 2024

AbstractThe thermal conductivity of many materials depends on temperature due to several factors, including variation of heat capacity with temperature, changes in vibrational dynamics with temperature, and change in volume with temperature. For proteins some, but not all, of these influences on the variation of thermal conductivity with temperature have been investigated in the past. In this study, we examine the influence of change in volume, and corresponding changes in vibrational dynamics, on the temperature dependence of the thermal conductivity. Using a measured value for the coefficient of thermal expansion and recently computed values for the Grüneisen parameter of proteins we find that the thermal conductivity increases with increasing temperature due to change in volume with temperature. We compare the impact of thermal expansion on the variation of the thermal conductivity with temperature found in this study with contributions of heat capacity and anharmonic coupling examined previously. Using values of thermal transport coefficients computed for proteins we also model heating of water in a protein solution following photoexcitation.
Investigating the antecedents of Sustainable Development Goals disclosure via social media: Evidence from water companies
Authors: Nicolo' Giuseppe , Cervilla‐Bellido José María 
Published: December 2024

AbstractThis study extends academic knowledge on the sustainable development goal (SDG) disclosure practices of water companies via social media. The ultimate paper's goal is to examine the possible determinants of such disclosure practices. A manual content analysis was conducted on a sample of 64 Spanish water companies' official Twitter accounts to determine the SDG disclosure level. Based on legitimacy theory, different regression models were estimated to identify possible financial and governance explanatory factors of the level of SDG disclosure provided by Spanish water companies via Twitter. Results reveal that Spanish water companies are still slow to realise the potential of social media to increase their engagement with stakeholders and legitimise their position in society concerning their commitment to achieving SDGs. More profitable companies with less government ownership and larger boards appear more prone to disclose SDG information.
Seasonal Variations in Habitat Use are Associated With Food Availability Changes in Assamese Macaques (Macaca assamensis) Inhabiting Limestone Forest
Authors: Mo Fengxiang , Liu Guanghua , Wang Ailong , Liu Shengyuan , Nong Shixin , Zhang Kechu , Huang Zhonghao 
Published: December 2024

ABSTRACTData on habitat use of wild animals facilitate conservation management and further our understanding of their environmental adaptations. We collected data on the habitat utilization of 16 groups of Assamese macaques (Macaca assamensis) in the limestone forests in Guangxi, China, to explore the pattern and seasonality of habitat use of these macaques. Our results showed that cliffs were the most frequently used hill parts by the macaques, followed by flat zones, hillsides, and hilltops. The cliffs were the most frequently used during resting and moving, whereas the hillsides and flat zones were used as the main feeding sites. Patterns of habitat use seasonally varied. Specifically, the utilization frequency of the cliff was lower in the rainy season than in the dry season. Besides, feeding occurred more frequently on hillsides and flat zones. The dietary composition of the Assamese macaques affected the use of hill parts, indicating that the consumption of young leaves was positively correlated with the use of cliffs and was passively related to the use of hillsides. Moreover, ecological factors had impacts on habitat use. The use of hilltops and cliffs increased whereas the utilization of hillsides and flat zones decreased with the day length and temperature dropping. The availability of flower and fruit were also key ecological factors affecting habitat utilization. We conclude that the dietary composition, day length, flower availability, and fruit availability are determinants of habitat utilization for Assamese macaques, highlighting the importance of ecological factors in shaping their behavioral adaptation to the unique limestone forests.
Abundance‐mediated species interactions
Authors: Twining Joshua P. , Augustine Ben C. , Royle J. Andrew , Fuller Angela K. 
Published: December 2024

AbstractSpecies interactions shape biodiversity patterns, community assemblage, and the dynamics of wildlife populations. Ecological theory posits that the strength of interspecific interactions is fundamentally underpinned by the population sizes of the involved species. Nonetheless, prevalent approaches for modeling species interactions predominantly center around occupancy states. Here, we use simulations to illuminate the inadequacies of modeling species interactions solely as a function of occupancy, as is common practice in ecology. We demonstrate erroneous inference into species interactions due to error in parameter estimates when considering species occupancy alone. To address this critical issue, we propose, develop, and demonstrate an abundance‐mediated interaction framework designed explicitly for modeling species interactions involving two or more species from detection/non‐detection data. We present Markov chain Monte Carlo (MCMC) samplers tailored for diverse ecological scenarios, including intraguild predation, disease‐ or predator‐mediated competition, and trophic cascades. Illustrating the practical implications of our approach, we compare inference from modeling the interactions in a three‐species network involving coyotes (Canis latrans), fishers (Pekania pennanti), and American marten (Martes americana) in North America as a function of occupancy states and as a function of abundance. When modeling interactions as a function of abundance rather than occupancy, we uncover previously unidentified interactions. Our study emphasizes that accounting for abundance‐mediated interactions rather than simple co‐occurrence patterns can fundamentally alter our comprehension of system dynamics. Through an empirical case study and comprehensive simulations, we demonstrate the importance of accounting for abundance when modeling species interactions, and we present a statistical framework equipped with MCMC samplers to achieve this paradigm shift in ecological research.
Recent Advances of B−P Coupling Reactions: Conventional and Efficient Alternative Routes
Authors: Gayen Sourav , Ghosh Sundargopal 
Published: December 2024

AbstractAmine‐boranes (AB) and phosphine‐boranes (PB), valence isoelectronic counterparts of carbon‐based substances, present fascinating opportunities because of their formal charge separation. This characteristic electronic feature renders them compelling for both fundamental investigations and practical uses in main group chemistry. Notably, phosphine‐boranes have experienced comparatively minimal advancements due to the inherent weakness of the B−P bonds and the polarized nature of the P−C bonds. While dehydrogenative coupling reactions offer atom‐economical methods, alternative and convenient approaches to B−P coupling have remained insufficiently explored over the years. This review consolidates the significant research on dehydrocoupling reactions and alternative B−P coupling strategies, emphasizing the progress and challenges in this evolving field. The work highlights the potential of transition metal‐catalyzed routes, offering insights into the mechanistic aspects that drive the synthesis of B−P coupled materials.
Study on combustion characteristics under methanol gasoline emission optimization based on orthogonal matrix analysis
Authors: Du Danfeng , Hao Zewei , Guo Xiurong , Jiang Wenjun , Yang Shaochi 
Published: December 2024

AbstractThis study utilizes the orthogonal matrix analysis method to identify the lower levels of both conventional and unconventional emissions in engines powered by methanol gasoline, with the aim of optimizing gas emissions. Through the utilization of ANOVA, we were able to determine the key elements that impact the emissions of methanol gasoline from engines. Additionally, we validated the correctness of the experiment by employing the signal‐to‐noise ratio. The analysis focused on the combustion parameters of an engine that burns methanol fuel while maintaining low overall emissions. The accuracy of the numerical simulation was confirmed through the utilization of GT‐power for numerical simulation and subsequent experimental validation. The findings suggest that when the engine operates at a load of 1200 rpm and 6 N m while consuming M85, there is a reduction in both conventional and unconventional emissions. M85 has a maximum cylinder pressure that is 18.7% more than pure gasoline. Conversely, pure gasoline demonstrates a power output that is 24.7% higher than M85. Additionally, M85 has a BSFCe that is 22.71% higher than gasoline. The addition of a methanol‐gasoline mixture can effectively reduce the engine's exhaust temperature.
D‐Chiro Inositol Supplementation and the Occurrence of Gestational Diabetes: A Randomized Controlled Trial in China
Authors: Chen Xinning , Du Zhimei , Zhang Zhanwei , Chen Danqing 
Published: December 2024

ABSTRACTTo investigate the effect of D‐chiro inositol (DCI) supplementation on perinatal outcomes in pregnant women at high risk of gestational diabetes mellitus (GDM), we conducted a prospective, randomized, placebo‐controlled study. Eligibility criteria included women aged ≥ 35 years old, with a pre‐pregnancy body mass index ≥ 24 kg/m2, having a family history of type 2 diabetes, having a history of GDM, polycystic ovary syndrome, or a history of delivering macrosomia infants. Participants who were recruited at a gestational age of 12–16 weeks, were randomly to receive either DCI 500 mg twice daily or to receive a placebo for 12 weeks. Outcome measured included the occurrence of GDM and other perinatal outcomes. Between 2020 and 2022, 276 participants were enrolled, with 139 in the DCI Group and 137 in the Control Group. Occurrence of GDM was significantly lower in the DCI group compared to that in placebo group (24.8% vs. 38.1%, p = 0.027). A significant difference was observed in the 1‐h glycemia during the oral glucose tolerance test (OGTT) (8.35 ± 1.55 vs. 8.81 ± 1.85, p = 0.043), however, no significant differences in the fasting glucose level or 2‐h glycemia between the two groups. The mean birth weight of newborns in the control group was significantly heavier than in the DCI group (3487.9 ± 437.7 g vs. 3341.6 ± 420.1 g, p = 0.011). Therefore, DCI supplementation in early pregnancy can reduce the occurrence of GDM in women at high risk.Trial Registration: ClinicalTrials.gov identifier: NCT 04801485
Transcriptomic and Metabolomic Insights Into the Prebiotic Potential of Camellia Seed Oil for Enhancing Akkermansia muciniphila Proliferation In Vitro
Authors: Chen Xi , Zhu Yong , Mazhar Muhammad , Qin Likang 
Published: December 2024

ABSTRACTCamellia seed oil (CSO), a potential prebiotic agent, can significantly increase the relative abundance of Akkermansia muciniphila (A. muciniphila) in mice gut microbiota following oral administration, this study aims to investigate the enhancing effect in vitro. The results showed that after 24‐h co‐cultivation with 0.5% (v/v) CSO, the growth of A. muciniphila increased from 11.61 ± 0.04 Log10CFU/mL to 12.17 ± 0.10 Log10CFU/mL (p < 0.05), accompanied by a reduction in the oxidation–reduction potential (ORP) value of the media from −126.67 ± 1.78 mV to −117.33 ± 0.72 mV (p < 0.05). Additionally, squalene and (+)‐α‐tocopherol, bioactive compounds present in CSO, were found to promote A. muciniphila proliferation (squalene OD600: 1.086 ± 0.002, tocopherol OD600: 1.100 ± 0.003, DMSO control OD600: 0.991 ± 0.003, p < 0.0001). Transcriptomic and metabolomic profiling revealed 464, 121, and 194 differentially expressed genes (DEGs) and 212, 160, and 156 differentially expressed metabolites (DEMs) in A. muciniphila co‐cultivated with CSO after 4, 16, and 24 h, respectively (p < 0.05). The upregulated DEGs and DEMs were primarily enriched in pathways associated with energy generation (e.g., gap, icd, sucC, GOZ73_RS04175, succinate, phosphoenolpyruvate), nucleotide metabolism (e.g., mazG, deoxyguanosine), amino acid metabolism (e.g., argF, metK, L‐tyrosine), translation (e.g., rplO, rpmC), and environmental adaptation (e.g., murA, katE, reduced nicotinamide adenine dinucleotide). These findings suggest that various bioactive compounds present in CSO exhibit prebiotic effects on the in vitro proliferation of A. muciniphila by facilitating nutrient utilization and environmental adaptation. This study provides insights into the extended utilization of CSO.
Extreme Phenotypic Variability of ACTG1‐Related Disorders in Hearing Loss
Authors: Bernardi Maria T. , Ramzan Memoona , Calderon Laura , Salvatore Franco , De Rosa Maria Agustina , Bivona Stephanie , Armando Romina , Vazquez Natalia , Azcoiti Maria Esnaola , Marti Marcelo A. , Arberas Claudia , Ropelato Maria Gabriela , Olha Silvina , Lam Byron L. , Telischi Fred F. , Tekin Mustafa , Walz Katherina 
Published: December 2024

AbstractHearing loss is the most common sensory defect in humans, affecting normal communication. In most cases, hearing loss is a multifactorial disorder caused by both genetic and environmental factors, but single‐gene mutations can lead to syndromic or non‐syndromic hearing loss. Monoallelic variants in ACTG1, coding for gamma (γ)‐actin, are associated with classical Baraitser‐Winter Syndrome type 2 (BRWS2, nonsyndromic deafness, and a variety of clinical presentations not fitting the original BRWS2 description or nonsyndromic deafness. Here two unrelated patients with ACTG1 variants are reported, having severe hearing loss as a common phenotype but with different clinical presentations, supporting the extreme variability of ACTG1‐related disorders.
Thinking About the Birth Father: Loss, Longing, Ambivalence, and Indifference Among Adopted Adolescents With Lesbian Mothers
Authors: Goldberg Abbie E. , Brodzinsky David M. 
Published: December 2024

ABSTRACTAdopted youth often have contact with or at least information about birth family members—but such relationships or knowledge rarely extend to birth fathers. The current study explores ideas, feelings, and questions about birth fathers among youth raised by two mothers, including whether or not they desire contact. Interviews were conducted with 25 adolescents, ages 13–19 years. Thematic analysis of narratives revealed seven groups of respondents who displayed a range of interests, feelings, and contact desires in relation to birth fathers. Some adolescents had limited information about or interest in their birth fathers, others showed ambivalence and uncertainty, and still others voiced curiosity and strong interest. A few articulated a sense of a fathers ‘absence’ and a longing for a fatherly presence. The data are interpreted in the context of ambiguous loss, uncertainty management, and gender perspectives. Implications for future research, adoption practice, and adoptive parenting are considered.
Morphoanatomy and Histochemistry of Symplocos tetrandra (Mart.) Mart. (Symplocaceae)
Authors: Garcia Juliana de Fátima , Armstrong Lorene , da Rocha Leandro Taborda , dos Anjos Cíntia Aparecida , Fladzinski Karine Amorim , Miguel Marilis Dallarmi , Miguel Obdulio Gomes , Montrucchio Deise Prehs , Dias Josiane de Fátima Gaspari 
Published: December 2024

ABSTRACTThe Symplocaceae family comprises 406 species, all of which are classified within a single genus, Symplocos Jacq., which is distributed across multiple continents. In Brazil, this genus is predominantly found in the Atlantic Forest and Cerrado regions and is characterized by the presence of secondary metabolites, such as iridoids, terpenoids, and saponins with biological activities. Moreover, the literature research has unveiled the potential of this genus for antimicrobial, antitumor, and anti‐HIV applications. This research conducted morphoanatomical, histochemical studies using light microscopy and scanning electron microscopy (SEM) analysis of the leaves and stems of Symplocos tetrandra (Mart.) Mart. Cross‐sections and paradermal were performed. The investigation revealed the presence of prismatic calcium oxalate crystal in petiole and druses calcium oxalate crystals, in petiole and leaf blade. Paracytic stomata on the abaxial surface, lignified pith in the stem, which was detected with the phloroglucinol staining. Oil bodies, uniseriate epidermis, and a thin lipidic cuticle were confirmed with Sudan III. These findings suggest potential anatomical markers for taxonomic classification of the species. The data obtained in this study contributes for species identification, and the presence of metabolites can guide future pharmacological investigation with S. tetrandra.
Ridge dimensional changes and implant stability utilizing the osseodensification protocol: A randomized clinical trial
Authors: Saqr Aziz M. , Ayilavarapu Srinivas , Gandhi Kavan , Lee Chun‐Teh , Stylianou Popi 
Published: December 2024

AbstractBackgroundThere is limited evidence on the effect of osseodensification drilling (OD) on alveolar ridge dimension changes and implant stability compared to standard drilling (SD). The purpose of this study was to compare the effect of both drilling protocols on ridge dimensional changes and implant stability.MethodsFifteen patients were recruited for a total of 20 pairs of implants. Pre‐ and postdrilling ridge widths were measured at the crest and 5 and 10 mm apical to the crest, using a premarked surgical guide as a reference to standardize recordings. Following implant placement, insertion torque and implant stability quotients (ISQ) were recorded. ISQ were also recorded at 3, 6, and 12 weeks post‐op. Six‐month post‐op changes in buccal bone thickness (BBT) were measured via pre‐op and post‐op cone beam computed tomography (CBCT) superimposition analysis.ResultsGreater ridge width changes were observed at the crest and 5 mm apical from the crest, favoring OD, with no difference at 10 mm. When comparing BBT 6 months post‐op, OD maintained BBT better than SD. Additionally, greater insertion torque, ISQ, and high implant stability (HIS) were observed following OD compared to SD.ConclusionOD results in greater ridge dimensional changes compared to SD following osteotomy preparation, predictably maintains BBT and reduces the risk of buccal dehiscence and resorption, obtains superior torque at placement, higher ISQ values, and a greater number of implants achieving HIS, which is maintained throughout the entire healing period.
Efficacy of Oral Rehabilitation Techniques in Patients With Oral Cancer: A Systematic Review and Meta‐Analysis
Authors: Saini Ravinder S. , Vyas Rajesh , Mosaddad Seyed Ali , Heboyan Artak 
Published: December 2024

ABSTRACTOral cancer commonly affects various parts of the oral cavity, including the lips, tongue, gums, palate, and inner cheeks. Oral rehabilitation involves multiple approaches aimed at restoring and improving oral function, esthetics, and overall well‐being. This study assessed the functional outcomes and quality of life in patients who underwent rehabilitation following an oral cancer diagnosis. A comprehensive literature search was performed across PubMed, Cochrane Library, Dimensions, ScienceDirect, CINAHL, and Google Scholar databases. The study included patients diagnosed with oral cancer who had undergone oral rehabilitation. Functional outcomes and quality of life were key selection criteria. The methodological quality of the included studies was assessed, and data were systematically extracted and analyzed. A significant relationship was observed between the type of maxillectomy and quality of life, with obturator retention and stability being critical factors. Radiotherapy was found to adversely impact oral function and implant survival rates, with a strong correlation between radiation treatment and reduced implant survival (p < 0.00001). Additionally, dentition and the timing of implant placement were associated with recurrence rates and adverse effects. The findings highlight the crucial role of oral rehabilitation in improving both functional outcomes and quality of life in oral cancer patients. This study underscores the importance of incorporating oral rehabilitation into oral cancer treatment to enhance patient recovery and overall health.
Power Clamping in Second Harmonic Generation Within an On‐Chip Lithium Niobate Microdisk
Authors: Fu Botao , Gao Renhong , Yao Ni , Lin Jintian , Wang Min , Qiao Lingling , Cheng Ya 
Published: December 2024

AbstractOn‐chip lithium niobate (LN) microresonator is regarded as a promising candidate for power clamping in second harmonic generation (SHG) owing to its high‐quality factor, small mode volume, and large nonlinear coefficient. To date, various theories have been proposed to describe the three‐wave mixing mechanism within a LN microresonator, while a comprehensive understanding of mode evolution and its impact on nonlinear frequency conversion efficiency especially for power clamping, is still limited. Here, the dual‐resonance detuning dynamics are investigated theoretically and the effect of mode chord angles on nonlinear frequency conversion efficiency is analyzed. Experimentally, two distinct power clamping points, including the normalized conversion efficiency of ≈38% mW−1 and output power of ≈1.2 mW, are separately observed in the same microresonator, consistent with the theoretical model. The results clarify the physical mechanism behind the power clamping in the observed SHG and offer a unique approach to achieving efficient and powerful SHG in LN microresonators.