bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of interactive videogame in allaying preoperative anxiety in pediatric surgical patients - A randomized controlled study
Authors: Vinay AP , Karna ST , Ahmad Z , Waindeskar V , Ahmed R , Kuttan KA 
Published: November 2024

ABSTRACT

Introduction:
Non-pharmacological distraction using video games (VG) is still under-explored in pediatric surgical patients.

Materials and Methods:
We conducted this randomized controlled study of 150 children, aged 4–12 years, scheduled for elective surgery in a tertiary care hospital to estimate the distractive effect of VG on immediate preoperative anxiety in children. In the intervention group (I), playing with VG was encouraged till anesthetic induction. The control group (C) received usual care with verbal reassurance. Modified Yale preoperative anxiety scale (mYPAS) score and presence of anxiety (mYPAS >30) were noted in the preoperative area (T1), at parental separation (T2), and anesthetic induction (T3). Parental separation anxiety score (PSAS) >3 was considered unacceptable parental separation. We used the Mann-Whitney test and t-test to find significance of intergroup mean difference of anxiety and logistic regression to find risk factors for immediate preoperative anxiety.

Results:
The mean m-YPAS (±SD) scores at T1 and T2 were 38 (±10.9) and 52.2 (±18.7) in group C and 46.5 (±13.5) and 33 (IQR: 28.3–65.5) in group I, respectively. The incidence of anxiety at T2 was higher in group C (81.3%) than in group I (59%). More children in group I (53/75) had acceptable separation than in group C (32/75) (P = 0.001). VG led to a 2.32 times lower risk of anxiety at T2 (P = 0.036). In children with acceptable separation, the incidence of anxiety was lower in group I (59%) than in group C (87%).

Conclusion:
VG-based distraction effectively reduced preoperative anxiety in children undergoing elective surgeries.
Counting homomorphisms from surface groups to finite groups
Authors: Klug Michael R. 
Published: November 2024

AbstractWe prove a result that relates the number of homomorphisms from the fundamental group of a compact nonorientable surface to a finite group G, where conjugacy classes of the boundary components of the surface must map to prescribed conjugacy classes in G, to a sum over values of irreducible characters of G weighted by Frobenius-Schur multipliers. The proof is structured so that the corresponding results for closed and possibly orientable surfaces, as well as some generalizations, are derived using the same methods. We then apply these results to the specific case of the symmetric group.
Global trends and hotspots of type 2 diabetes in children and adolescents: A bibliometric study and visualization analysis
Authors: Zhang Fang-Shuo , Li Hai-Jing , Yu Xue , Song Yi-Ping , Ren Yan-Feng , Qian Xuan-Zhu , Liu Jia-Li , Li Wen-Xun , Huang Yi-Ran , Gao Kuo 
Published: November 2024

BACKGROUND
Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus (T2DM) among children and adolescents worldwide. Due to rapid disease progression, severe long-term cardiorenal complications, a lack of effective treatment strategies, and substantial socioeconomic burdens, it has become an urgent public health issue that requires management and resolution. Adolescent T2DM differs from adult T2DM. Despite a significant increase in our understanding of youth-onset T2DM over the past two decades, the related review and evidence-based content remain limited.
AIM
To visualize the hotspots and trends in pediatric and adolescent T2DM research and to forecast their future research themes.
METHODS
This study utilized the terms “children”, “adolescents”, and “type 2 diabetes”, retrieving relevant articles published between 1983 and 2023 from three citation databases within the Web of Science Core Collection (SCI, SSCI, ESCI). Utilizing CiteSpace and VoSviewer software, we analyze and visually represent the annual output of literature, countries involved, and participating institutions. This allows us to predict trends in this research field. Our analysis encompasses co-cited authors, journal overlays, citation overlays, time-zone views, keyword analysis, and reference analysis, etc.
RESULTS
A total of 9210 articles were included, and the annual publication volume in this field showed a steady growth trend. The United States had the highest number of publications and the highest H-index. The United States also had the most research institutions and the strongest research capacity. The global hot journals were primarily diabetes professional journals but also included journals related to nutrition, endocrinology, and metabolism. Keyword analysis showed that research related to endothelial dysfunction, exposure risk, cardiac metabolic risk, changes in gut microbiota, the impact on comorbidities and outcomes, etc., were emerging keywords. They have maintained their popularity in this field, suggesting that these areas have garnered significant research interest in recent years.
CONCLUSION
Pediatric and adolescent T2DM is increasingly drawing global attention, with genes, behaviors, environmental factors, and multisystemic interventions potentially emerging as future research hot spots.
Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes
Authors: Wang Ji-Kui , Zhang Di , Wang Jin-Feng , Lu Wan-Lin , Wang Jing-Yuan , Liang Shi-Feng , Liu Ran , Jiang Jing-Xin , Li Hong-Tao , Yang Xuan 
Published: November 2024

BACKGROUND
At present, the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent, to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes, the report is as follows.
AIM
To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus (T2DM).
METHODS
We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral anastomosis. Metabolic indicators were collected preoperatively, as well as at 3 and 6 months postoperative. The metabolic indicators analyzed included body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), 2-hour blood glucose (PBG), glycated hemoglobin (HbA1c), fasting C-peptide, 2-hour C-peptide (PCP), fasting insulin (Fins), 2-hour insulin (Pins), insulin resistance index (HOMA-IR), β Cellular function index (HOMA-β), alanine aminotransferase, aspartate aminotransferase, serum total cholesterol (TC), low-density lipoprotein cholesterol (L DL-C), triglycerides (TG), high-density lipoprotein, and uric acid (UA) levels.
RESULTS
SBP, DBP, PBG, HbA1c, LDL-C, and TG were all significantly lower 3 months postoperative vs preoperative values; body weight, BMI, SBP, DBP, FBG, PBG, HbA1c, TC, TG, UA, and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months; and PCP, Fins, Pins, and HOMA-β were all significantly higher 6 months postoperative vs at 3 months (all P < 0.05).
CONCLUSION
Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.
Role of macrophage polarization in diabetic foot ulcer healing: A bibliometric study
Authors: Zhang You-Wen , Sun Lei , Wang Yan-Nan , Zhan Shi-Yu 
Published: November 2024

BACKGROUND
Diabetic foot ulcers (DFUs) are a significant contributor to disability and mortality in diabetic patients. Macrophage polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU healing. However, the complex mechanism, the difficulty in clinical translation, and the large heterogeneity present significant challenges. Hence, this study was to comprehensively analyze the publication status and trends of studies on macrophage polarization and DFU healing.
AIM
To examine the relevant literature on macrophage polarization in DFU healing.
METHODS
A bibliometric analysis was conducted using the Web of Science database. Relevant literature was retrieved from the Web of Science Core Collection database between 2013 to 2023 using literature visualization and analysis software (VOSviewer and CiteSpace) and bibliometric online platforms. The obtained literature was then subjected to visualization and analysis of different countries/regions, institutions, journals, authors, and keywords to reveal the research’s major trends and focus.
RESULTS
The number of publications on the role of macrophage polarization in DFU healing increased rapidly from 2013 to 2023, especially in the latter period. Chinese researchers were the most prolific in this field, with 217 publications, while American researchers had been engaged in this field for a longer period. Qian Tan of Nanjing Drum Tower Hospital and Qian Ding of Nanjing University were the first to publish in this field. Shanghai Jiao Tong University was the institution with the most publications (27). The keywords “bone marrow”, “adjustment, replacement, response, tissue repair”, and “activation, repair, differentiation” appeared more frequently. The study of macrophage polarization in DFU healing focused on the regulatory mechanism, gene expression, and other aspects.
CONCLUSION
This study through the bibliometric method reveals the research trends and development trends in this field of macrophage polarization in DFU healing from 2013 to 2023 in the Web of Science Core Collection database. The key hotspots in this field mainly include the regulation of macrophage activation, gene expression, wound tissue repair, and new wound materials. This study provides references for future research directions.
Facile synthesis of thiophene-embedded Baicalein via oxidative cyclization and anticancer activity against ovarian cancer cells via inhibiting PI3K/MTOR signaling pathway: in-vitro and in-silico study
Authors: Liu Zheqi , Zeng Lin , Wu Linshan , Song Daping , Chen Yanhua 
Published: November 2024

This study illustrated the synthesis of a thiophene-embedded Baicalein (BAC) conjugate through the formation of a chalcone backbone, accomplished by refluxing hydroxyl-acetophenone with 5-nitrothiophene-2-carbaldehyde in the presence of piperidine. The BAC conjugate (5,6,7-trihydroxy-2-(5-nitrothiophen-2-yl)-4H-chromen-4-one) was obtained through the oxidative cyclization of the previously synthesized chalcone using DMSO/I2. The structure of BAC was determined by FTIR, 1H-NMR, 13C-NMR, mass spectrometry, and elemental analysis. The impact of BAC on SKOV-3 ovarian cancer cells was assessed via several pharmacological assays, including viability, apoptosis, migration, invasion, and cell cycle analysis. RT-qPCR analysis was performed to assess the impact of BAC on the mRNA levels of Bcl2, Bax, PI3K, Akt, and mTOR. BAC underwent docking analysis utilizing the 3D crystal structure of PI3K. The results indicate that BAC decreases cell viability, migration, invasion, and induces cell cycle arrest at the G2/M phase in SKOV-3 cells in a concentration-dependent manner. The Annexin FITC assay demonstrated the activation of apoptosis by increasing Bax expression and decreasing Bcl2 expression. The mRNA expression of PI3K, Akt, and mTOR was considerably suppressed relative to the untreated control, potentially through interactions with Trp201, Gln291, Leu657, Arg690, Phe694, and Arg849 of PI3K.
Keyword: Cell-viability, Apoptosis, Migration, Cell-cycle, RT-qPCR, Docking
Bull. Chem. Soc. Ethiop. 2025, 39(2), 367-379.
DOI: https://dx.doi.org/10.4314/bcse.v39i2.14
Synthesis of some novel dipeptides and their copper(II) complexes of (dibenzo [b, d] furan-2-ylsulfonyl) phenylalanine
Authors: O. Moustafa Gaber , A. Almehizia Abdulrahman , M. Naglah Ahmed , A. Zen Amer 
Published: November 2024

A new series of dipeptide candidates (6-11) and corresponding octahedral copper complexes (12-15) were prepared by the synthesis of dibenzofuran-2-sulfonyl chloride (3). Then, the acid chloride (3) was coupled, at low temperature, with DL-phenylalanine using triethylamine and gave the corresponding acid (4) as starting material, which was converted to dibenzofuran-2-sulphonyl-DL-phenylalanyl chloride (5) using thionyl chloride. The latter acid chloride (5) was coupled with some aliphatic amino acids and gave the corresponding dibenzofuran-2-sulphonyldipeptide candidates (6, 7). Moreover, dibenzofuran-2-sulphonyldipeptide methyl ester derivatives (8, 9) were prepared via the esterification of the corresponding candidates (6, 7) and hydrazinolysis with hydrazine hydrate 99% of methyl esters (8, 9) to give the corresponding peptide hydrazides (10, 11). Then, all the newly prepared peptide derivatives (6-11) were reacted with copper acetate to afford the corresponding copper complexes (12-15). The newly synthesized compounds (6-15) were characterized.
KEY WORDS: Dibenzofuran-2-sulfonyl-DL-phenylalanyl chloride, Amino acids, Linear dipeptides, Copper complexes.
Bull. Chem. Soc. Ethiop. 2025, 39(2), 301-311.
DOI: https://dx.doi.org/10.4314/bcse.v39i2.9
Assessment RP1249 All-rac-alpha-tocopheryl Acetate (Vitamin E)
Authors:   Food Standards Agency,   Food Standards Scotland
Published: November 2024

The Food Standards Agency and Food Standards Scotland (FSA/FSS) have reviewed an assessment of application RP1249 for the renewal of authorisation of all-rac-alpha-tocopheryl acetate (vitamin E) for its use as a nutritional additive in all animal species. This feed additive application has been made to renew the authorisation in Great Britain (GB) as it is 10 years since the product was authorised and placed on the market in the EU. The same product and uses have been authorised in multiple other countries as the information and data demonstrate the regulatory criteria are met. This feed additive had its application for renewal of authorisation assessed by the European Food Safety Authority (EFSA) which was published in 2021. FSA/FSS have reviewed the information available, including the EFSA renewal opinion1 and confirmed that all-rac-alpha-tocopheryl acetate (vitamin E), as described in this application, is unlikely to have any adverse effect on human or animal health or the environment in the context of its intended uses in GB.
Assessment RP1367 Lactiplantibacillus Plantarum DSM 23375
Authors:   Food Standards Agency,   Food Standards Scotland
Published: November 2024

The Food Standards Agency and Food Standards Scotland (FSA/FSS) have reviewed an assessment of application RP1367 for the renewal of authorisation of Lactiplantibacillus plantarum DSM 23375 for its use as a technological additive, functional group of silage additive, in all animal species. This feed additive application has been made to renew the authorisation in Great Britain (GB) as it is 10 years since the product was authorised and placed on the market in the EU. The same product and uses have been authorised in multiple other countries as the information and data demonstrate the regulatory criteria are met. This feed additive had its application for renewal of authorisation assessed by the European Food Safety Authority (EFSA), which was published in 2023. FSA/FSS have reviewed the information available, including the EFSA renewal opinion1 and confirmed that Lactiplantibacillus plantarum DSM 23375, as described in this application, is unlikely to have any adverse effect on human or animal health or the environment in the context of its intended uses in GB.
Safety Assessment RP1047 Quillaja Saponaria and Yucca Schidigera (Magni-Phi®)
Authors:   Food Standards Agency,   Food Standards Scotland
Published: November 2024

An application was submitted to the Food Standards Agency in April 2021 from Phibro Animal Health Corporation (“the applicant”) for the new authorisation of an additive (Magni-Phi®), a natural preparation of powdered dry Quillaja saponaria and dry Yucca schidigera, under the category “zootechnical additives” and functional group “digestibility enhancer and other (performance enhancer)”. The additive is proposed to be used in all avian species (excluding laying and breeding birds), with a proposed inclusion rate of 250 mg/kg of complete feed. The Advisory Committee on Animal Feedingstuffs (ACAF) was asked to review the dossier and the supplementary information submitted by the Applicant, and to advise the Food Standards Agency and Food Standards Scotland (FSA/FSS) in evaluating the dossier. The Advisory Committee on Animal Feedingstuffs (ACAF) initially evaluated the identity and characterisation of the additive. Upon receiving further information relating to the identity of the product, the manufacturing process, management of potential contaminants and homogeneity, the Committee concluded that the additive was correctly identified and characterised. The FSA/FSS concluded, based on the ACAF’s advice, that the additive can be considered safe for the target species, consumers, and the environment. With regard to user safety, the additive should be considered potentially harmful by inhalation, and as a potential eye irritant and skin sensitiser. The additive is not a skin irritant. The additive can be considered efficacious in broiler chickens when included in complete feed at a minimum dose of 250 mg/kg. This efficacy data can be extrapolated to other poultry for fattening and ornamental birds. The views of ACAF have been taken into account in this safety assessment which represents the opinion of the FSA/FSS.
Assessment RP1528 Lactiplantibacillus Plantarum (Formerly Lactobacillus Plantarum) NCIMB 30084
Authors:   Food Standards Agency,   Food Standards Scotland
Published: November 2024

The FSA/FSS Food Standards Agency and Food Standards Scotland (FSA/FSS) have reviewed an assessment of application RP1528 for the renewal of authorisation of Lactiplantibacillus plantarum (previously lactobacillus) NCIMB 30084 for its use as a technological additive, functional group of silage additive, in all animal species. This feed additive application has been made to renew the authorisation in Great Britain (GB) as it is 10 years since the product was authorised and placed on the market in the EU. The same product and uses have been authorised in multiple other countries as the information and data demonstrate the regulatory criteria are met. This feed additive had its application for renewal of authorisation assessed by the European Food Safety Authority (EFSA), which was published in 2023. FSA/FSS have reviewed the information available, including the EFSA renewal opinion1 and confirmed that Lactiplantibacillus plantarum NCIMB 30084, as described in this application, is unlikely to have any adverse effects on human or animal health or the environment in the context of its intended uses in GB.
Safety Assessment RP1087 Guanidinoacetic Acid (Creamino®)
Authors:   Food Standards Agency,   Food Standards Scotland
Published: November 2024

An application was submitted to the Food Standards Agency in May 2021 from AlzChem Trostberg GmbH (“the applicant”) for the new use authorisation of an additive guanidinoacetic acid (Creamino®), under the category of ’nutritional additives” and functional group “amino acids, their salts, and analogues”. The additive is proposed to be used in all animal species with a proposed level of inclusion in feed of 1.2 kg/ 1,000 kg (0.12 %) of complete feedingstuffs with a moisture content of 12%. The Advisory Committee on Animal Feedingstuffs (ACAF) was asked to review the dossier and the supplementary information submitted by the Applicant, and to advise the Food Standards Agency and Food Standards Scotland (FSA/FSS) in evaluating the dossier. The FSA/FSS concluded, based on the ACAF’s advice, that the additive was correctly identified and characterised. No causes for concern were raised in this section of the dossier. The additive can be considered safe for target species, consumers, and the environment. The additive is not irritant to eyes or skin and is not a dermal sensitiser or toxic through inhalation. It is advised that appropriate dusk masks are worn when handling the additive, due to its high dusting potential. No additional safety risks are to be expected if the additive were to be categorised as a “zootechnical additive”. The additive can be considered efficacious for growing pigs and poultry. No conclusion could be reached on efficacy for the other target species requested. The views of ACAF have been taken into account in this safety assessment which represents the opinion of the FSA/FSS.
Assessment RP1051 All-rac-alpha-tocopheryl Acetate (Vitamin E)
Authors:   Food Standards Agency,   Food Standards Scotland
Published: November 2024

The Food Standards Agency and Food Standards Scotland (FSA/FSS) have reviewed an assessment of application RP1051 for the renewal of authorisation of all-rac-alpha-tocopheryl acetate (vitamin E) for its use as a nutritional additive in all animal species. This feed additive application has been made to renew the authorisation in Great Britain (GB) as it is 10 years since the product was authorised and placed on the market in the EU. The same product and uses have been authorised in multiple other countries as the information and data demonstrate the regulatory criteria are met. This feed additive had its application for renewal of authorisation assessed by the European Food Safety Authority (EFSA) which was published in 2021. FSA/FSS have reviewed the information available, including the EFSA renewal opinion and confirmed that all-rac-alpha-tocopheryl acetate (vitamin E), as described in this application, is unlikely to have any adverse effect on human or animal health or the environment in the context of its intended uses in GB.
Tourism Storytelling Research Progress and Trends: A Systematic Literature Review on SDGs
Authors: Li Han , Zeng Shengke , Tay Kaixin 
Published: November 2024

Introduction: As travelers seek safer, more meaningful experiences, storytelling has become vital in destination marketing. Aligned with the Sustainable Development Goals (SDGs), it promotes sustainable development, low-carbon practices, and eco-friendly tourism.

Objective: The objective of this study is to investigate the current state, research hotspots, and emerging trends in storytelling within the tourism field, with the aim of providing a comprehensive overview of existing research, identifying key areas of focus, and highlighting potential directions for future studies.

Method: The methodology adopted for this research comprises a bibliometric analysis of storytelling in the tourism field over the past 18 years, based on the Web of Science (WOS) database. The study design involved conducting co-authorship analysis, co-citation analysis, and keyword analysis using the visualization tool CiteSpace 6.1.

Results: The results obtained revealed that both independent and collaborative research in this field are relatively limited, leading to a lower overall research impact. The lack of widely influential research outcomes has further affected the frequency of citations and the centrality of the literature within academic networks. Additionally, keyword analysis identified four key research areas in the current studies: the application of storytelling in destination marketing; pathways and methods for enhancing tourist experiences through storytelling; the use of storytelling in the promotion and preservation of cultural heritage; and the application of digital storytelling in tourism. Possible discrepancies and limitations of the study are also considered in this section.