bluuebunny/crossref_metadata_2025_split huggingface dataset:
A combined debridement, antibiotics, and implant retention (DAIR) procedure with flap coverage for acute soft tissue defects following total knee arthroplasty: a retrospective study
Authors: Boadas-Gironès Laia , Sabater-Martos Marta , Ferrer-Banus Marc , Soriano-Viladomiu Àlex , Martínez-Pastor Juan Carlos 
Published: October 2024

Abstract. Acute soft tissue defects, such as persistent drainage, wound dehiscence, or necrosis, following total knee arthroplasty (TKA) can lead to the devastating complication of deep infection. Typically, when a medium-sized defect is present, a gastrocnemius flap is widely employed for soft tissue reconstruction due to its low morbidity and favourable functional outcomes. When facing this situation, we should consider associating the coverage treatment with a debridement, antibiotics, and implant retention (DAIR) surgery procedure, in order to treat a possible acute infection, even when the diagnosis of infection is not clear. We performed a retrospective study to compare TKA outcomes in patients with DAIR and flap procedures in the same surgical act against those who had received an isolated flap procedure for soft tissue reconstruction after an acute surgical wound defect. Patients had been identified from a prospectively collated TKA database. Between 2005 and 2021, 18 patients met our inclusion criteria, with a mean follow-up of approximately 8 years. A medial gastrocnemius flap procedure was performed for 15 patients (83 %). We compared the rates of infection clearance between the two groups. No differences in comorbidities or risk factors were observed between both groups. In the combination treatment group, 66.6 % of patients healed after treatment compared to 33.3 % in the isolated flap group. Although no significant statistical differences were found, the association of DAIR with the muscle flap procedure is highly recommended in the treatment of acute soft tissue defects after TKA. Further studies with larger sample sizes are necessary to extrapolate these findings to the general population.
TEOS-10 and the climatic relevance of ocean–atmosphere interaction
Authors: Feistel Rainer 
Published: October 2024

Abstract. Unpredicted observations in the climate system, such as recent excessive ocean warming, are often lacking immediate causal explanations and are challenging numerical models. As a highly advanced mathematical tool, the Thermodynamic Equation of Seawater – 2010 (TEOS-10) was established by international bodies as an interdisciplinary standard and is recommended for use in geophysics, such as, and in particular, in climate research. From its very beginning, the development of TEOS-10 was supported by Ocean Science through publishing successive stages and results. Here, the history and properties of TEOS-10 are briefly reviewed. With focus on the air–sea interface, selected current problems of climate research are discussed, and tutorial examples for the possible use of TEOS-10 in the associated context are presented, such as topics related to ocean heat content, latent heat, and the rate of marine evaporation; properties of sea spray aerosol; or climatic effects of low-level clouds. Appended to this article, a list of publications and their metrics is provided for illustrating the uptake of TEOS-10 by the scientific community, along with some continued activities, addressing still pending, connected issues such as uniform standard definitions of uncertainties of relative humidity, seawater salinity, or pH. This article is dedicated to the jubilee celebrating 20 years of Ocean Science. This article is also dedicated to the memory of Wolfgang Wagner, who sadly and unexpectedly passed away on 12 August 2024. His contributions to TEOS-10 are truly indispensable constituents; Wolfgang was an essential co-author of various related documents and articles. He will be deeply missed. All the rivers run into the sea; yet the sea is not full; unto the place from whence the rivers come, thither they return again.
The King James Bible: Ecclesiastes, 450–150 BCE He wraps up the waters in his clouds, yet the clouds do not burst under their weight.
Holy Bible: New International Version, Job 26:8 Of the air, the part receiving heat is rising higher. So, evaporated water is lifted above the lower air.
Leonardo da Vinci: Primo libro delle acque, Codex Arundel, ca. 1508 Two-thirds of the Sun's energy falling on the Earth's surface is needed to vaporize … water … as a heat source for a gigantic steam engine.
Heinrich Hertz: Energiehaushalt der Erde, 1885 The sea-surface interaction is obviously a highly significant quantity in simulating climate.
Andrew Gilchrist and Klaus Hasselmann: Climate Modelling, 1986 The climate of the Earth is ultimately determined by the temperatures of the oceans.
Donald Rapp: Assessing Climate Change, 2014
Features of Vascularization of the Transitional Zone of the Uterus in Patients with Chronic Nonspecific Endometritis
Authors: Pomortsev A. V. , Kuzmenko E. A. , Kuzmenko N. N. , Dyachenko Yu. Yu. , Avakyan S. M. 
Published: October 2024

Aim. Тo study the peculiarities of blood supply to the transitional zone of the uterus in patients with chronic nonspecific endometritis (ChE).Materials and methods. 106 women aged 22–45 years were examined. The main group included 72 patients with morphologically verified chronic endometritis. We distinguished subgroup I (n = 39.37%) of HE with an autoimmune component, subgroup II (n = 33.31%) with HE without an autoimmune component, as well as a control group consisting of 34 patients with a normal result of morphological examination. Transabdominal and transvaginal ultrasound examination (ultrasound) of the uterus and appendages was performed on the 18th–23rd day of the cycle, with the calculation of the parameter proposed by US — the coefficient of vascularization of the transitional zone of the uterus (k).Outcomes. In the control group, the average k value was 32 ± 2.6%, in the subgroup of patients with an autoimmune component (subgroup I) — 17.0 ± 4.0%, in the subgroup with a nonimmune component (subgroup II) — 23.0 ± 3.4%.Statistically significant differences in the k value were obtained between subgroup I and all the others, but there were no differences between subgroup II and the control group.Autoimmune nonspecific HE was predicted when the vascularization coefficient was below 20.9%. In nonimmune nonspecific HE, the resulting model was not statistically significant. Nonimmune nonspecific HE was predicted when the vascularization coefficient was equal to or higher than 18.6%.Under normal conditions, the resulting model was statistically significant. The norm was predicted when the vascularization coefficient was equal to or higher than 27.6%.Conclusion. The proposed coefficient of vascularization of the transitional zone of the uterus (k) showed high diagnostic value in patients with nonspecific СhE and it can be recommended for inclusion in the ultrasound examination protocol at the stage of pre-gravidar preparation.
Features of Magnetic Resonance Diagnostics of Tenosynovial Giant Cell Tumor (Pigmented Villonodular Synovitis)
Authors: Potemkina T. V. , Konopleva Yu. Yu. , Petrova E. B. 
Published: October 2024

Aim. Demonstrate the features of magnetic resonance diagnostics of tenosynovial giant cell tumor.Materials and Methods. Using magnetic resonance imaging, we identified patients with tenosynovial giant cell tumor of the knee joint, describing the diagnostic features and clinical course of diffuse and local forms of the tumor.Results. Specific MRI patterns of tenosynovial giant cell tumor are hemosiderin deposits, villous and nodular growths of the synovium of the knee joint, joint effusion and bone erosion.Conclusion. Тenosynovial giant cell tumor is a rare mesenchymal neoplasm arising from the synovium of joints and tendon sheaths, disabling young able-bodied people. Magnetic resonance imaging, being the “gold” standard for radiological diagnostics, helps to identify specific patterns.
Tamoxifen Retinopathy. An Uncommon but Serious Complication: Case Report
Authors: Pierre Lucas  Linhares , Pierre Lara Linhares , Pierre-Filho Paulo de Tarso Ponte 
Published: October 2024

Tamoxifen is a selective estrogen receptor modulator most widely used in the treatment of hormone-dependent breast cancer. We describe a case of a 51-year-old woman treated with tamoxifen for 4 years who had gradual diminution of vision in both eyes of three months duration. On examination, visual acuity was 20/40 in the right eye and 20/50 in the left eye. A fundus examination revealed bilateral symmetric crystalline deposits in the macula. There were characteristic structural changes on spectral domain-optical coherence tomography, including abnormalities of the ellipsoid zone and outer nuclear layer. Subsequently, tamoxifen was switched to anastrozole. Despite cessation of tamoxifen, her vision did not improve. The clinical presentation of tamoxifen retinopathy is discussed, along with the importance of regular ophthalmic examination for individuals receiving tamoxifen, even in low doses.
ОНЛАЙН МААЛЫМАТ КАРАЖАТТАРЫНЫН МАЗМУНУ ЖАНА АУДИТОРИЯСЫ
Authors: Дуйшонбаева Аида Байышевна , Сатыбалдиева Чыныхан Топчубаевна 
Published: October 2024

Азыркы массалык маалымат каражаттарынын техникалык негизин санариптик жана компьютердик технологиялар түзгөндүгүнүн натыйжасында, алардын социалдык-саясий функционалдуулугу өзгөрүүгө дуушар болууда. Ал эми макалада эгемендүү Кыргыз Республикасындагы онлайн-массалык маалымат каражаттарынын заманбап аудиториясы, мазмуну жана экономикалык талаасы каралып талдоого алынды. Интернет маалымат каражаттарына өтүү жараяны дал ушул онлайн маалымат каражаттарына тиешелү экендигин көрүгө болот. Интернеттин Жалпыга Маалымдоо Каражаттарынын мазмунунун жана тенденцияларын аныктоо үчүн, “Chalkan.kg” жана “Gezitter.org” маалымат сайттарынын базасында кароо мүмкүн болду. Андан башка Маалыматтык жазуунун популярдуу жанрынан тышкары, онлайн медиада кайра жазуу жана копирайтинг деп аталган кеңири таралган техногендү маалымат каражаттарынынын тарыхы көрсөтүлдү.
КЫРГЫЗ КООМУНДАГЫ ШАЙЛОО ТАЖРЫЙБАЛАРЫ ЖАНА АЗЫРКЫ КӨЙГӨЙЛӨРҮ (САЯСИЙ-СОЦИОЛОГИЯЛЫК ТАЛДОО)
Authors: Жусубалиев Абдикайым Рысбаевич , Патиев Нурканбек Маматович 
Published: October 2024

Макалада XIX кылымдын экинчи жарымында Кыргызстандын азыркы территориясы падышалык Россиянын курамына каратылгандан кийин административдик-саясий башкаруу системасындагы өзгөрүүлөр, киргизилген жаңы башкаруу системасы менен байланышкан саясий өзгөрүүлөр, болуштук шайлоо практикасы талдоого алынган. Анда бул саясий өзгөрүүлөрдүн калктын аң-сезимине, анын жашоо образына, социалдык түзүлүшүнө тийгизген таасирлери каралган. Падышалык бийлик административдик башкаруунун ынтаа коюп иштеген жергиликтүү калктын өкүлдөрүнүн чинин көтөрүү, мураска калтыруу укугу менен пайдаланууга жерлерди берүү, ардак наамдарын ыйгаруу, орден, медалдарды тапшыруу сыяктуу кызыктыруучу практикаларды кеңири колдонгон. XIX кылымдын 2-жарымында түптөлгөн кыргыз коомунун мындай саясий түзүлүшү жана башкаруу системасы 1917-жылдан кийинки Кеңеш бийлигинин киргизилишине чейин дээрлик өзгөрбөй сакталып калган. Бул процесстер, шайлоо практикалары кыргыздар үчүн алгачкы шайлоо тажрыйбалары катары тарыхый мааниге ээ болуп, Улуу Октябрь төңкөрүшүнөн кийин да, азыркы эгемендүүлүк мезгилинде да андагы терс тажрыйбалардын таасири башкаруу системасындагы кээ бир мүчүлүштүктөрдүн башаты болуп калган сыяктуу.
КУРМАНЖАН ДАТКА ЖАНА ОРУС ГЕНЕРАЛДАРЫ: КЫЗМАТЫНЫН БААЛАНЫШЫ, СЫЙЛЫКТАРЫ
Authors: Абытов Байболот Капарович 
Published: October 2024

Макалада даңазалуу “Алай ханышасы” Курманжан-датканын жана аны менен ар түрдүү мезгилдерде, ар кандай шарттарда карым-катнашта болгон, атактуу орус гене­ралдары - Россия империясынын Түркстан генерал-губернаторствосунун генерал-гу­бер­на­торлору менен Фергана облусунун аскер губернаторлорунун ишмердүүлүгүн чагыл­дырууга аракет жасалган. Көпчүлүккө маалым болгондой атактуу мекендешибиз Курман­жан-датканын бай өмүр таржымалы, ар тараптуу ишмердүүлүгүнүн бардык тармак­тары жана аспектилери деталдуу түрдө, дээрлик изилденгендей көрүнүп, таасир калты­рат. Бирок дагы да болсо датка айымдын өмүр баянында, айрыкча орус генералдары, Орус империясынын Түркстан генерал-губернаторствосунун жогорку даражалуу аскер чинов­ник­­тери, Россия империясынын согуш министри А.Н.Куропаткин менен болгон жеке мамиле­лери боюнча дагы эле аз изилденген жагдайлар бар. Кызыгууну туудурган жаг­дайдын би­ри, Курманжан-датканын 1875-76-жылдардагы Кокон хандыгындагы элдик көтөрүлүш­кө болгон мамилеси, көтөрүлүштүн жетекчилеринин бири, акырына чейин согуш­кан, жеңил­генден кийин бөтөн жерде каза болгон уулу Абдылдабек болот. Өзгөчө кызыгуу­ну туудур­ган маселе Курманжан-датканын Россия империясынын расмий сыйлыктарына ээ болуу­су. Ошол эле учурда Орус бийликтеринин кичүү уулу Камчыбекти бажычыларды жок кылганы үчүн өлүм жазасына тартышын, туруктуулук жана сабыр­дуулук менен баштан кечириши, уулдарынын, небересинин Сибирге айдалышы болгон. XIX кылымдын аягында Түркстан генерал-губернаторствосунун бийлик эгедерлерине уулдарын жана небересин меке­нине кайтарууга көптөгөн өтүнүч менен кайрылган. Өзүнүн жеке аброю, бир катар генерал-губернаторлордун натыйжалуу жардамы менен балдарын, небересин Сибирь сүр­гүнөн бошотуга, өз мекенине кайтарууга жетишкен.
ИСХАК АСАН УУЛУ ПОЛОТ ХАНДЫН ЖЕТЕКЧИЛИГИ АСТЫНДАГЫ КӨТӨРҮЛҮШТҮН ПОСТСОВЕТТИК ТАРЫХНААМАДА ИЗИЛДЕНИШИНИН КЭЭ БИР МАСЕЛЕЛЕРИ
Authors: Алымбаев Жээнбек , Баитова Фарида Турганбаевна 
Published: October 2024

Совет мезгилиндеги тарыхнаамада азаттык үчүн күрѳшкѳн элдин аракеттерине баа берүүдөгү илимий жыйынтыктар партиянын идеологиялык багытына шайкеш келүүсү зарылдык катары саналган. Элдик кыймылдарга баа берүүдѳ окумуштуулар таптык позициядан карап, совет мамлекетинин негизги урааны болгон “таптык эзүүгѳ каршы күрѳш”, “бай-манаптык”, “буржуазиялык элементтерге каршы күрѳшүү” сыяктуу калыптанган түшүнүктѳрдү колдонушкан. Андан айырмаланып, постсоветтик тарыхнаамадагы изилдѳѳлөрдүн негизги ѳзгѳчѳлүктѳрү катары азаттык кѳтѳрүлүштѳр элдин эркиндикке умтулган аракеттери катары бааланып, анын жетекчилерине элдик баатыр, улуу тарыхый инсан катары баа берүү тенденциясы жүрүп келүүдѳ. 1873-76-жылдардагы Фергана өрөөнүндө болгон элдик кыймылдын мааниси жана ал кыймылдын жүрүшүндөгү Исхак Асан уулу Полот хандын ролу постсоветтик мезгилдеги тарыхнаамада кыргыз, өзбек окумуштуулары тарабынан жаңы көз караштан изилденип, анын натыйжасында бир канча маӊыздуу эмгектер жаралып, макалалар жарык көрдү
Far from the Madding Crowd at 150: Seven Reflections
Authors: Guiliano Edward , Henchman Anna , Hennessy Jr. Mark M. , Jackson Jeffrey Edward , Jenkins Melissa Shields , Kim Jane E. , Lorentzen Eric G. , Yamboliev Irena 
Published: October 2024

ABSTRACT
Seven scholars of Victorian literature reflect on Thomas Hardy’s Far from the Madding Crowd in honor of the 150th anniversary of its publication. The authors reflect their personal responses to the novel, and each has a unique focus.
Reading and Attention in Wharton’s Modernity and Our Own
Authors: Coit Emily 
Published: October 2024

Abstract
How might Edith Wharton’s thoughts about readers and reading speak to anxieties about the fate of reading in our own moment? This short article places Wharton in conversation with the contemporary thinker Maryanne Wolf, identifying some overlap and also some disagreement in their views about technology’s effects on attention, imagination, and reading. Wharton’s critical representations of readers, the essay suggests, offer a salutary reminder that fears about bad reading have long attended advances in technology; and Wolf’s hortatory account of the virtues and benefits of reading finds a proleptic critique in Wharton’s unabashed celebration of irony and pleasure.
Una primera aproximación a la relación entre margen e inversión a nivel de empresa en la economía española
Authors: Puente Díaz Sergio , Mulino Ríos Maristela 
Published: October 2024

Motivación
Tanto la inversión como los márgenes empresariales experimentaron una caída en 2020, pero se han ido recuperando desde entonces. La explotación estadística de microdatos empresariales permite estimar qué relación ha existido entre ambas variables en la economía española en los últimos años.
Ideas principales
•Tras la caída de 2020, los márgenes empresariales han venido aumentando en nuestro país. Este incremento se ha concentrado en las empresas que presentaban unos menores márgenes en 2019. En cambio, para las empresas con mayores márgenes antes del estallido de la pandemia, estos han mostrado, en conjunto, una evolución descendente.
•La relación entre margen e inversión, calculada a partir de datos granulares de empresa, tiene forma de U invertida: es positiva para márgenes por debajo de cierto umbral, pero se torna negativa para márgenes por encima de dicho umbral.
•En la economía española, la mayoría de las empresas se sitúan en el tramo en el que la relación entre margen e inversión es positiva. Aquellas ubicadas en el tramo en el que la relación es negativa tienden a ser, en comparación con el resto, más pequeñas, más jóvenes y más productivas.
EFFICACY OF NEOADJUVANT TARGETED THERAPY IN TREATMENT OF PATIENTS WITH LOCALISED CLEAR-CELL RENAL CELL CARCINOMA
Authors: BANGASH MH , ALI J , CHANDIO K , HAMMAD M , RIND SR 
Published: October 2024

Clear-cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, accounting for approximately 75-80% of all renal malignancies. Objectives: The main objective of the study is to find the efficacy of neoadjuvant targeted therapy in the treatment of patients with localised clear-cell renal cell carcinoma. Methods: This prospective study was conducted at Mardan Medical Complex from June 2023 to January 2024. Data were collected from 85 patients. Patients aged>18 years and have a histologically confirmed diagnosis of localized ccRCC were included in the study. Tumor size was required to be 4 cm or larger, but confined to the kidney, corresponding to Stage I to III disease. Results: Data were collected from 85 patients with an average baseline tumour size for the entire cohort was 7.5 cm, and after 12 weeks of treatment, tumours shrank to an average of 5.6 cm, resulting in a mean tumour reduction of 25%. In the sunitinib group, the tumour size decreased from 7.5 cm to 5.55 cm, reflecting a 26% reduction. Similarly, in the pazopanib group, the tumour size was reduced from 7.5 cm to 5.65 cm, with an average reduction of 24%. Conclusion: It is concluded that neoadjuvant targeted therapy, using agents such as sunitinib and pazopanib, effectively reduces tumour size and improves surgical outcomes in patients with localized clear-cell renal cell carcinoma.
Development and Validation of a Method for Detecting and Quantifying Mitragynine in Kratom Samples Using HPLC-PDA
Authors: Isnaeni Neni , Saefumillah Asep , Cahyana Antonius Herry 
Published: October 2024

Kratom (Mitragyna speciosa Korth) has been identified as a New Psychoactive Substance (NPS) by the United Nations Office on Drugs and Crime (UNODC) and included in the list of prohibited ingredients in food supplements and traditional medicine by Indonesian FDA. Therefore, a rapid, easy, and reliable analytical method is necessary to detect and quantify this plant and its products. This study developed a method for the detection and quantification of kratom products based on a unique compound, mitragynine, as a biomarker. A previous survey of determining mitragynine in Kratom using GC-MS, LC-MS/MS, UPLC, and HPLC-PDA. Previously, the HPLC-PDA method used a C8 column. Yet, for efficiency, it is also necessary to develop a test method using a C18 column. Analysis was performed using an HPLC - PDA system with Waters Atlantis T3-C18 (250 x 4.6 mm, 5 µm) column. The mobile phase comprises acetonitrile and formic acid 0.05%, pH 5.0 (75:25 v/v), delivered at a 1.0 mL/min flow rate. Detection was carried out at a wavelength of 225 nm. The analytical method was validated with test parameters of selectivity, system suitability, accuracy, precision, linearity, detection limit, and quantification limit. The validation study demonstrated an excellent linear concentration range of 1.96 - 6.01 µg/mL with a correlation coefficient of 0.9996; the detection limit is 0.14 µg/mL, while the limit of quantification is 0.45 µg/mL—accuracy method of 98.88 - 101.44% and a bias of 0.27%. The percent relative standard deviation for six independent assay determinations was 0.67%, and the intermediate precision was 1.56% on two days. The mitragynine amounts in these materials ranged from 6.01 to 6.31 mg/g of dried leaf material. Based on the research results, it can be concluded that the method developed provides quick, simple, reliable, accurate, and valid, and has an advantage over existing methods in terms of simplicity of sample preparation, short analysis time, and cost-effectiveness compared to GCMS and LCMS/MS and can be applied for future analysis in Kratom samples.
A EFETIVIDADE DA VARA CRIMINAL ESPECIALIZADA EM CRIME ORGANIZADO- LEI N º 12.694/12: A ALTERNÂNCIA NA COMPOSIÇÃO DOS MAGISTRADOS JUÍZES MULTIFACETADOS
Authors: Santos Lorena de Medeiros 
Published: October 2024

O presente estudo não pretende exaurir todas as inovações instituídas pela Lei 12.694/2012, restringindo-se aos aspectos procedimentais relativos ao processo e julga-mento das ações que tenham por objeto crimes praticados por organizações criminosas, objetivando a análise das normas legais impostas na regulamentação da atuação e for-mação dos colegiados de Magistrados que exercerão suas funções nas Varas Especiali-zadas de combate ao crime organizado, além de incentivar medidas e garantias legais a esses magistrados, que por sua própria natureza põem em risco a sua segurança pes-soal e de seus familiares. Deve-se analisar quais mecanismos podem ser utilizados com as normas regulamentares (Lei nº 12.694/12, Lei 13.964/2019 e resoluções n°03/2006 e nº 77/2019, ambas do CNJ), a fim de garantir uma composição de magistrados na Vara especializada no combate ao crime organizado, desde a colheita de provas até sentença final, de forma célere e com redução de riscos e exposição dos membros e seus familia-res. Dessa forma, indaga-se como será possível flexibilizar os princípios da identidade física do juiz, do juiz natural, a garantia da inamovibilidade dos juízes e as normas da Lei 12.694/12 em favor de uma prestação de jurisdição célere, imparcial (livre de interferên-cias externas) e que preserve as garantias dos réus (princípio da publicidade e da ampla defesa) sem expor os magistrados a riscos de segurança. Outrossim, a questão da alter-nância nesta composição pode ser aliada a garantia da inamovibilidade dos Magistrados? Uma análise a luz da ADI 4414 julgada pelo STF propõe-se a figura de um “Juiz multiface-tados”..
The Influence Of Transformational Leadership And Job Characteristics On Innovative Work Behavior And Employee Performance In The Setda Environment Of Ketapang Regency
Authors: Pulungan Hornop , Heryadi Heryadi , Pratomo Hurip 
Published: October 2024

The purpose of this study is to explain the effect of transformational leadership on: 1. Characteristics of work, 2. Innovative work behavior, and explain the influence of: 3. Transormational leadership 4. Characteristics of work, 5. Innovative work behavior, on employee performance in the Regional Secretariat of Ketapang. The study was carried at the Regional Secretariat of Ketapang, to use quantitative research and Path analysis with program SPSS 21. Data collection is the Questionnaire method. The number of respondents in this study is 35 respondents. The results of this study indicate that each variable has a positive and significant effect, transformational leadership and work characteristics is a positive and significant effect on innovative work behavior, and transformational leadership, work characteristics and innovative work behavior is a positive and significant effect on employee performance.