bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of neutrophil extracellular traps in the development of diabetic nephropathy using diabetic murine models
Authors: Jeon You Hyun , Oh Se-Hyun , Jung Soo-Jung , Oh Eun-Joo , Lim Jeong-Hoon , Jung Hee-Yeon , Choi Ji-Young , Park Sun-Hee , Kim Chan-Duck , Kim Yong-Lim , Hong Chang-Won , Cho Jang-Hee 
Published: November 2024

Abstract
Background
Diabetic nephropathy (DN) is a progressive complication among patients with diabetes and the most common cause of end-stage kidney disease. Neutrophil extracellular traps (NETs) are known to play a role in kidney disease, thus this study aimed to determine their role in the development of diabetic kidney disease using diabetic murine models.

Results
Protein and histological analyses revealed that db/db mice and streptozotocin DN models expressed no significant NET-related proteins, myeloperoxidase, citrullinated histone H3 (citH3), neutrophil elastase, and lymphocyte antigen 6 complex locus G6D (Ly6G). However, the inflamed individuals in the DN model showed that citH3 and Ly6G were highly deposited in the renal system based on immunohistochemistry images. In vitro, NET treatment did not induce apoptosis in glomerular endothelial and renal tubular epithelial cells. NET inhibition by DNase administration demonstrated no significant changes in cell apoptosis.

Conclusions
NET-related proteins were only expressed in the DN model with tubulointerstitial inflammation. Our study revealed that NETs are only induced in mice with hyperglycemia-induced inflammation.
Terrains of care in the smart city: sensemaking by creative communities of practice
Authors: Zaman Sara , Nurmi Suvielise , Raymond Christopher M. 
Published: November 2024

AbstractCritical smart city research has presented wide-ranging risks of technocentric urban development. One critique lies in the kinds of citizenship directed under smart urban paradigms, which do little to account for residents’ practices of care. This paper is an ethico-onto-epistemological re-examination of smart cities through the lens of care practices specifically focusing on creative communities of practice. We use an enactivist empirical approach to help uncover experiences of sensemaking in the smart city held by three creative communities of practice in Helsinki. Through in-depth interviews with n = 22 urban planners, artists, and community space organizers, we assessed these groups’ differing and overlapping sensemaking processes. Utilizing 5E sensemaking processes (embodied, extended, enacted, emotive, and embedded) as a flexible analytical framework, we identify and interpret their practices of care as ways of sensemaking in a developing smart urban environment. Our results depict terrains of care in which participation and citizenship in the smart city is not neutral, but embedded in affective engagement, navigating rules and institutions, and cultivation of joy and inspiration. We use our findings to discuss what these interweaving terrains of care mean for citizenship and transformational change in the smart city.
Diagnostic utility of testosterone priming prior to dynamic tests to differentiate constitutional delay in puberty from isolated hypogonadotropic hypogonadism in boys
Authors: Ahmed Shimaa Medhat Abdellatif , Badawi Nora ElSaid , AbdElSalam Mohamed Ahmed , Fawaz Lubna , Kamel AbdelKarim , Hassan Mona Mamdouh 
Published: November 2024

Abstract
Background
Differentiation between isolated hypogonadotropic hypogonadism (IHH) and constitutional delay in puberty (CDP) throughout adolescence can be challenging for doctors. This study examines the withdrawal effects of short-term, low-dose testosterone treatment (testosterone priming) on the ability of dynamic testing to distinguish between CDP and IHH based on activation of the hypothalamo-pituitary–testicular axis.

Methods
A case–control study included 20 boys with delayed puberty (group A) and 20 patients with IHH (group B). Both groups underwent Triptorelin and human chorionic gonadotropin (hCG) stimulation tests before and 2 months after testosterone injections (100 mg) intramuscularly every 4 weekly for 3 months.

Results
The triptorelin-stimulated 4-h LH with a cutoff of 2.4 IU/L and the hCG-stimulated testosterone with a cutoff of 1.160 ng/mL had sensitivities of 65% each, and specificities of 90% and 95%, respectively, to diagnose CDP. After testosterone withdrawal, the cut-off values for 4-h LH were 8.850 IU/L and 3.190 ng/mL for hCG-stimulated testosterone. Basal inhibin B > 88.25 pg/ml was found to be a differentiating factor in diagnosing CDP after testosterone withdrawal.

Conclusions
following the withdrawal of testosterone therapy, Inhibin B levels or 4-h stimulated LH are the most effective discriminant assays to distinguish CDP from IHH.
Factors Associated With Default of Treatment and Follow-Up Among Patients With Cancer: A Cross-Sectional Study From a Lower-Middle-Income Country
Authors: Sundriyal Deepak , Kapoor Mayank , Antil Preeti , Gupta Sweety , Kumar Parmod , Shriwastav Ujjawal Kumar , Sehrawat Amit 
Published: November 2024

PURPOSE
Desirable outcomes during the treatment of patients with cancer require adherence to evaluation, treatment, and follow-up. This study aimed to evaluate the factors associated with default in patients with cancer.

MATERIALS AND METHODS
We included patients with a histologically confirmed diagnosis of cancer who defaulted during evaluation, treatment, and follow-up. All patients’ detailed demographic and clinical data were recorded. Those lost to follow-up were interviewed telephonically. The factors associated with default were noted. Descriptive statistics were used to compute the demographic and clinical characteristics.

RESULTS
In total, 172 patients were included. Geriatric and female patients were 38.9% and 37.2%, respectively. Fifty-eight percent of the patients lived in rural areas, whereas 45.9% were illiterate. More than one third (34.3%) of the patients who defaulted received the curative-intent treatment, whereas 62.1% of patients had a good performance status immediately before default. The average distance traveled by the patients to reach the cancer facility was 143 ± 13.15 km. The most common reasons for default were the lack of social support, financial constraints, difficulty in commuting, and too sick to come in 45 (26.2%), 35 (20.3%), 28 (16.3%), and 23 (13.4%) patients, respectively. Twenty-nine (16.9%) patients reported more than one reason for default.

CONCLUSION
Lack of social support, financial constraints, transportation barriers, and inadequate counseling by the health care provider serve as barriers to uninterrupted cancer care. These factors are often interrelated and can be attenuated by adopting the hub and spoke model. Simultaneously, a good relationship between the patient and the health care provider fostered by appropriate counseling is imperative to increase adherence to cancer treatment and improve the outcome.
A comparative test of the ΛCDM and Rh = ct cosmologies based on upcoming redshift drift measurements
Authors: Melia F. 
Published: November 2024

Abstract
A measurement of the redshift drift constitutes a model-independent probe of fundamental cosmology. Several approaches are being considered to make the necessary observations, using i) the Extremely Large Telescope (ELT), ii) the Cosmic Accelerometer, and iii) the differential redshift drift methodology. Our focus in this letter is to assess how these upcoming measurements may be used to compare the predictions of ΛCDM with those of the alternative Friedmann-Lemaître-Robertson-Walker cosmology known as the

universe, and several other models, including modified gravity scenarios. The ELT should be able to distinguish between

and the other models at better than

for

after 20 years of monitoring, while the Cosmic Accelerometer may be able to achieve the same result with sources at

after only 10 years.
Arginine Vasopressin Deficiency Heralding Rosai-Dorfman Disease With Neurological Manifestations
Authors: Felske David , Gabbay Jacob , Boles Brittney , Gilbert Matthew P 
Published: November 2024

Abstract
Rosai-Dorfman disease (RDD) is a rare heterogeneous disorder of non–Langerhans cell histiocytosis. The patient is a 24-year-old woman who presented with a 1-month history of polydipsia, polyuria, and 25-lb (11.3-kg) weight loss over 6 months and was found to have significantly elevated 24-hour urine volume (8.4 L). Prior to completion of the work-up for her presenting symptoms, she returned with a new complaint of disabling back pain and bilateral lower-extremity numbness with weakness refractory to conservative treatment. Magnetic resonance imaging (MRI) showed a prominent T2 to T4 stenosis from a soft tissue mass. Due to progressive pain and accelerating neurological symptoms, she was admitted for surgical debulking and biopsy. In the 10 hours she was unable to drink fluids surrounding her procedure, her serum sodium climbed to 160 mmol/L (reference interval, 137-145 mEq/L; [137-145 mmol/L]). Urine testing and desmopressin challenge revealed arginine vasopressin deficiency (AVP-D), formerly known as central diabetes insipidus. Pituitary MRI showed a mildly enlarged pituitary gland with loss of normal posterior pituitary signal supporting the diagnosis. Epidural mass pathology showed predominant histiocytes indicating RDD. This case highlights the diverse clinical manifestations of RDD and is an unusual instance of RDD linked with AVP-D and neurological involvement.
Is Adjuvant Therapy Necessary for Stage IB Gastric Cancer: A Retrospective Cohort Study
Authors: Gu Mingyu , Zhao Binghe , Sui Changda , Wen Minghai , Wang Xinxin 
Published: November 2024

Abstract
Background
The benefit of adjuvant therapy for patients with IB gastric cancer (GC) is a topic of debate. This study aimed to evaluate the benefit of adjuvant therapy for patients with IB GC.

Methods
Overall, the study selected 510 IB GC patients after gastrectomy at the First Medical Center of the Chinese PLA General Hospital, Beijing, China between 2005 and 2018. Overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan-Meier method and the log-rank test. Cox regression analyses were used to confirm the independent prognostic factors.

Results
Patients who received postoperative adjuvant therapy had a longer 5-year OS (92.9 %) than those who received surgery alone (86.7 %; P < 0.05), but the 5-year DFS did not differ significantly between the two groups (92.6 vs. 95.0 %; P > 0.05). Moreover, DFS did not differ between monotherapy, and combination therapy. Uni- and multivariate analyses showed that older age was a significant risk factor for tumor recurrence. Subgroup analyses also failed to identify suitable candidates for chemotherapy.

Conclusions
Because adjuvant therapy did not demonstrate any benefits in terms of tumor recurrence or DFS, these treatment strategies may be unnecessary for IB GC patients after gastrectomy. Further studies are required to identify subgroups of IB GC patients who may benefit from adjuvant treatments.
Psychological Distance and Algorithm Aversion: Congruency and Advisor Confidence
Authors: Kirshner Samuel N. 
Published: November 2024

Employees and consumers have varying preferences between human and algorithmic advisors. Drawing on construal level theory, I hypothesize that individual differences in algorithm aversion can be explained by the perception that algorithms are psychologically farther away than human advisors. The first set of studies (n = 266) shows that algorithms are viewed as abstract and distant compared with humans, even when their outputs are perceived at a low-level construal, challenging prior research. Leveraging construal congruency, the second set of studies (n = 1,148) shows that farther within-task psychological distance generally increases preference for algorithmic advisors due to differences in advisor confidence. Specifically, I contribute to the literature by showing that a far psychological distance within a task reduces confidence in human advisors. In contrast, confidence in algorithms remains stable, increasing algorithm appreciation at farther within-task distances. History: This paper has been accepted for the Service Science Special Issue on Navigating the Use of Technology in Service Marketing. Supplemental Material: The online appendix is available at https://doi.org/10.1287/serv.2023.0054 .
Fatores que interferem na saúde mental de adolescentes escolares no contexto rural
Authors: Silveira Andressa da , Soster Francieli Franco , Santos Lairany Monteiro dos , Probst Tamara , Oliveira Juliana Portela de , Vargas Tainara Giovana Chaves de , Soccol Keity Laís Siepmann 
Published: November 2024

Objetivo: conhecer os fatores que interferem na saúde mental de adolescentes escolares no contexto rural. Método estudo qualitativo e participativo, mediado pelo Método Criativo e Sensível, a partir da Dinâmica de Criatividade e Sensibilidade “Árvore do Conhecimento”, realizada com adolescentes de duas escolas rurais. As enunciações foram submetidas à análise de discurso francesa. Resultados: participaram do estudo 26 adolescentes, 11 provenientes da região noroeste e 15 da região central, com faixas etárias entre 12 e 17 anos. Emergiram três categorias: “Saúde mental e relações sociais/familiares de adolescentes escolares da área rural”; “Violência e sofrimento no cotidiano de adolescentes escolares da área rural”; “Estratégias de enfrentamento dos adolescentes para a melhoria da saúde mental”. Considerações finais: relações conflituosas estabelecidas com familiares, amigos e professores interferem na saúde mental dos adolescentes. Sugere-se a realização de atividades educativas, que discorram sobre a saúde mental, instigando a quebra de tabus com relação à temática.
Early impact of an integrated healthcare model on stakeholders in China
Authors: Wang Xueping , Trigo Virgínia , Mello-Sampayo Felipa de , Wei Wu , Ferreira Nuno B 
Published: November 2024

Background/Aims Since 2017, China has been implementing an integrated healthcare system, aiming to expand county hospitals, reduce patient expenses and deliver better care. This study aimed to evaluate the implementation of this model in Dancheng County, using stakeholder theory to analyse the views of all affected parties. Methods Participants living and working in Dancheng County were recruited from several groups, including: government officials, heads of healthcare organisations, healthcare staff, patients and suppliers. Both public and private healthcare institutions were included. Semi-structured interviews were conducted to collect data on participants' experiences and views of the new model. Interviews were recorded, transcribed and analysed using content analysis. Results Government officials and those working in public healthcare institutions were generally positive about the new model, reporting that it improved financial management, allowed more investment in county hospitals and reduced the profit-seeking behaviours of medical institutions. Patients noted good quality care at a reduced cost. However, private institutions and suppliers noted reduced income and increased supervision, which had negatively affected their profits. Conclusions The integrated model has brought several benefits, particularly to public healthcare institutions, staff and patients. This model may help to reduce profit-seeking behaviours in medical institutions. However, further development is needed to assess and mitigate the negative impact on stakeholders.
Designing the Contemporary Implementation of Traditional knowledge and Evidence (CITE) framework to guide the application of traditional knowledge in contemporary health contexts: a Delphi study
Authors: Steel Amie , Foley Hope , Bugarcic Andrea , Adams Jon , Leach Matthew , Wardle Jon 
Published: November 2024

Background:
The 2018 Declaration of Astana acknowledges the need to include traditional, complementary and integrative health care (TCIH) knowledge and technologies within primary health care. The World Health Assembly has also called member states to integrate TCIH into national healthcare systems. However, little attention has been given to developing supportive resources for this process in practice, policy, research and education.

Methods:
This study employed Delphi methodology to refine a framework for the evaluation and implementation of text-based traditional knowledge in contemporary health contexts. An international sample was recruited of expert participants with experience in a diversity of settings and disciplines. Framework items were retained, removed or modified based on participant consensus agreement on the importance of each item (consensus set at ≥75 per cent agreement), and mapped for comprehensiveness against an implementation framework.

Findings:
The initial survey round was completed by 19 participants and the second round by 15 participants. Most participants (n=15) held TCIH qualifications, representing six TCIH professions in total (naturopathy, Western herbal medicine, osteopathy, traditional Chinese and Oriental medicine, Ayurveda, and homeopathy). Participants typically had experience in multiple contexts across clinical practice, research, education and policy development. Consensus was achieved after two rounds and the resulting framework included three sections comprising guiding principles (five items), critical appraisal criteria (three items) and application criteria (eight items).

Conclusions:
As the international health community increasingly recognised the potential value and importance of TCIH knowledge and technologies, this Contemporary Implementation of Traditional knowledge and Evidence (CITE) Framework provides a timely and much-needed practical guide to rigorous and respectful traditional knowledge implementation.
Seroprevalence of viral hepatitis B and C infections among healthcare workers in Ethiopia: A systematic review and meta-analysis
Authors: Girmay Getu , Bewket Gezahegn , Amare Azanaw , Angelo Abiy Ayele , Wondmagegn Yenesew Mihret , Setegn Abebaw , Wubete Menberu , Assefa Muluneh 
Published: November 2024

Background
Healthcare workers (HCWs) are at higher risk of contracting hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Currently, there is no estimate of pooled data on the prevalence of HBV and HCV infections among HCWs in the country. Thus, this review aimed to determine the pooled prevalence of hepatitis B and C infections among HCWs in Ethiopia.

Materials and methods
A comprehensive literature search was conducted using electronic databases, including PubMed, Cochrane Library, Science Direct, Hinari, and African Journals Online to identify pertinent articles from the inception to April 2024. The protocol has been registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42024527940) and conducted per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were extracted independently by two authors and analyzed using STATA version 11 software. A random-effect model and Egger’s test were computed to estimate the pooled prevalence and assess publication bias, respectively.

Results
A total of 18 studies involving4,948 healthcare workers were included in this review to estimate the pooled prevalence of HBV and HCV infections among HCWs in Ethiopia. The overall prevalence of HBV was 5.93% (95% CI; 3.22–8.63). The sub-group analysis showed that the prevalence of HBV among medical waste handlers and health professionals was8.6% (95% CI; 3.01–14.13) and 4.98% (95% CI; 1.85–8.11), respectively. The combined prevalence of HCV was 1.12% (95% CI; -4.19–6.43). In the sub-group analysis, the prevalence of HCV among medical waste handlers and health professionals was1.44% (95% CI; -5.28–8.18) and 0.59% (95% CI; -8.09–9.27), respectively.

Conclusion
In this review, we found a higher (5.93%) and moderate (1.12%) prevalence of HBV and HCV infections, respectively among Ethiopian HCWs. Therefore, to reduce the infectious burden of HBV and HCV among HCWs; there is a need to strict adherence to infection prevention and control measures. In addition, adequate HBV vaccination coverage for HCWs is mandatory to reduce the burden of HBV infection in the country.
On comprehensive families of copulas involving the three basic copulas and transformations thereof
Authors: Saminger-Platz Susanne , Kolesárová Anna , Šeliga Adam , Mesiar Radko , Klement Erich Peter 
Published: November 2024

Abstract
Comprehensive families of copulas including the three basic copulas (at least as limit cases) are useful tools to model countermonotonicity, independence, and comonotonicity of pairs of random variables on the same probability space. In this contribution, we study how the transition from a (basic) copula to a copula modeling a different dependence behavior can be realized by means of ordinal sums based on one of the three basic copulas, perturbing one of the three basic copulas (considering some appropriate parameterized transformations) and truncating the results using the Fréchet-Hoeffding bounds. We provide results and examples showing the flexibility and the restrictions for obtaining new copulas or comprehensive families and illustrate the development of their dependence parameters.
Erkenntnistransfer und Transferforschung als Aufgabe von Fachdidaktiken – Blick über den Zaun
Authors: Prediger Susanne 
Published: November 2024

Zusammenfassung
Um Transfer aus den Fachdidaktiken in die Unterrichtspraxis (und zurück) zu ermöglichen, können materiale, personale und systemische Implementationsstrategien auf Unterrichts-, Fortbildungs- und Qualifizierungsebene verfolgt werden. In einem Blick über den Zaun werden Arbeitsweisen aus großen fachdidaktischen Fortbildungsprogrammen vorgestellt und drei Grundsätze verdeutlicht: (1) Ko-konstruktiver Transfer braucht Forschungs-Praxis-Partnerschaften auf mehreren Ebenen, (2) Inhaltlich treffsichere Implementation erfordert gegenstandsbezogen konkretisierte Innovationen, (3) eine Forschungsfundierung der Implementationsprogramme ist nicht nur bzgl. Gestaltungsqualitäten, sondern vor allem bzgl. Inhaltsqualitäten notwendig.
Die Praxis des konfessionell-kooperativen Religionsunterrichts. Eine Bilanz vorliegender empirischer Erkenntnisse
Authors: Riegel Ulrich , Zimmermann Mirjam 
Published: November 2024

Zusammenfassung
Auch weil bislang wenig didaktisches Material zum konfessionell-kooperativen Religionsunterricht vorliegt, kommt es zur Einschätzung dessen Praxis gegenwärtig vor allem darauf an, wie die Lehrpersonen konfessionssensible Lerngelegenheiten arrangieren, wie und ob sie die Schüler:innen zu einer differenzsensiblen Auseinandersetzung stimulieren und was diese im kokoRU lernen. Deshalb werden im vorliegenden Beitrag diesbezüglich die Datenlage zur Praxis im kokoRU bilanziert, einschlägige Einsichten aus der Literatur beschrieben und anschließend Implikationen für die Unterrichtspraxis abgeleitet. Dabei sollte bedacht werden, dass zwar vielfältige empirische Indizien zur Praxis des kokoRU vorliegen, diese jedoch durchgehend auf regional fokussierten Gelegenheitsstichproben beruhen und sich auf einen Zeitraum von 20 Jahren verteilen.
Die Studie „Praxis Religionsunterricht“ und ihr vielschichtiges Verhältnis zur Praxis des Religionsunterrichts
Authors: Rothgangel Martin 
Published: November 2024

Zusammenfassung
Dieser Artikel analysiert anhand einer Religionslehrer:innenbefragung den Zusammenhang zwischen Unterrichtsforschung und Unterrichtspraxis. Zu diesem Zweck werden zunächst der praxisbezogene Anlass der Studie sowie ihre Leitfragen in den Blick genommen. Davon ausgehend wird gezeigt, welche Potentiale die Unterrichtsforschung für die Unterrichtspraxis besitzt, zum anderen werden gleichfalls die Perspektivität von Praxisbeobachtungen sowie die Grenzen von Unterrichtsforschung bedacht. Im letztgenannten Sinne wird anhand ausgewählter Ergebnisse veranschaulicht, wie diese durch die jeweilige Erhebungs- bzw. Analysemethode bedingt sind. Schließlich wird der Blick auf Praxispotentiale von Unterrichtsforschung gerichtet, indem tatsächliche bzw. mögliche Effekte der vorliegenden Religionslehrer:innenbefragung thematisiert werden.