bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Randomized Trials Demonstrate Lactic Acid Supplementation in Pet Food Inhibits Dental Plaque, Calculus, and Tooth Stain in Cats
Authors: Scherl Dale S. , Coffman Lori , Davidson Stephen , Stiers Cheryl 
Published: September 2019

Background: Dental concerns are some of the most common health problems affecting companion animals. A variety of foods, treats, and chews comprising different mechanical and chemical technologies have been investigated as a means of promoting oral health. Here, we investigate the chemical technology, lactic acid added to a commercially available food, for its ability to inhibit dental plaque, calculus, and tooth stain accumulation in cats. Methods: Two separate feeding trials assessed the utility of a nutritionally complete feline maintenance food supplemented with lactic acid to reduce oral substrate accumulation (dental plaque, calculus, and tooth stain) in cats. After a calibration study identified high and low dental plaque formers, 45 cats were randomized to 1 of 2 test groups (food with 1.2% lactic acid supplementation) or control (food without lactic acid supplementation) groups, stratified based on their calibration scores. Data were collected on a monthly basis for 3 months. The second study randomly assigned 24 cats to either the test or control groups for 1 year, with data collected at the 6- and 12-month time points. Results: In the 3-month study, reductions in dental plaque, calculus, and tooth stain accumulations were observed at the 2-month assessment in both test groups compared with control ( P < .05 for test group 2). The 1-year study showed that these reductions in oral substrate accumulation persisted through the 6- and 12-month time points ( P < .05). Conclusions: Taken together, these studies demonstrate that lactic acid supplemented at 1.2% in a feline maintenance food significantly inhibits oral substrate accumulation.
The clinical characteristics of systemic lupus erythematosus patients in Indonesia: a cohort registry from an Indonesia-based tertiary referral hospital
Authors: Hamijoyo L , Candrianita S , Rahmadi A R , Dewi S , Darmawan G , Suryajaya B S , Rainy NR , Hidayat I I , Moenardi V N , Wachjudi R G 
Published: September 2019

Introduction To date, no national epidemiological data of systemic lupus erythematosus are available in Indonesia. Objective We aimed to demonstrate clinical characteristics of systemic lupus erythematosus patients of the Dr Hasan Sadikin General Hospital, one of Indonesia's top tertiary-referral hospitals. Method We reviewed retrospective cohort data from the Hasan Sadikin Lupus Registry, which was created in January 2016. Initial retrospective data were collected from the medical records of systemic lupus erythematosus patients from 2008 to 2015 and enhanced the cohort data from January 2016 to December 2017. The records were analysed for age, sex, clinical manifestations, comorbidity, treatment and outcome. Results Of 813 patients, 95.6% were females. Mean age at diagnosis was 27.7 ± 9.4 years, with a mean disease duration of 76.5 ± 53.1 months. Major clinical manifestations were arthritis (75.5%) and malar rash (68.3%). The majority of patients received steroid treatment, beside chloroquine and azathioprine. In total, 93 patients (11.4%) developed tuberculosis, 522 patients (64.2%) had routine follow-up and 66 patients (8.1%) died. Infection was the most common cause of death (36.4%). Conclusion Arthritis and malar rash were the most commonly encountered clinical manifestations in the Hasan Sadikin Lupus Registry. Tuberculosis incidence in systemic lupus erythematosus patients was high, as was the mortality rate of lupus.
Outcomes of stage I/II follicular lymphoma in the PET era: an international study from the Australian Lymphoma Alliance
Authors: Tobin Joshua W. D. , Rule Gabrielle , Colvin Katherine , Calvente Lourdes , Hodgson David , Bell Stephen , Dunduru Chengetai , Gallo James , Tsang Erica S. , Tan Xuan , Wong Jonathan , Pearce Jessica , Campbell Robert , Tneh Shao , Shorten Sophie , Ng Melissa , Cochrane Tara , Tam Constantine S. , Abro Emad , Hawkes Eliza , Hodges Georgina , Kansara Roopesh , Talaulikar Dipti , Gilbertson Michael , Johnston Anna M. , Savage Kerry J. , Villa Diego , Morris Kirk , Ratnasingam Sumi , Janowski Wojt , Kridel Robert , Cheah Chan Y. , MacManus Michael , Matigian Nicholas , Mollee Peter , Gandhi Maher K. , Hapgood Greg 
Published: September 2019

Key PointsPractices in early-stage FL are variable and include radiation alone, systemic therapy, CMT, or observation. Each practice resulted in similar excellent outcomes; randomized trials are required to determine the optimal treatment.
miR-145 sensitizes esophageal squamous cell carcinoma to cisplatin through directly inhibiting PI3K/AKT signaling pathway
Authors: Zheng Tian-Liang , Li De-Ping , He Zhan-Feng , Zhao Song 
Published: September 2019

AbstractBackgroundEsophageal squamous cell carcinoma (ESCC) is the eighth most common cancer worldwide and is one of the most lethal malignancies. Cisplatin (DDP) is a key drug for ESCC treatment, but the presence of chemotherapy resistance limits the use of DDP. To enhance chemosensitivity to DDP is important for ESCC treatment.MethodsqRT-PCR and Western blotting detected mRNA and protein expression in ESCC tissues and cells. Luciferase reporter assay assessed the interaction between miR-145 and AKT3. Cell cycle, apoptosis and proliferation were investigated with flow cytometry and MTT assay, respectively. Nude mice xenograft model was established, and immunohistochemistry (IHC) and TUNEL assay were conducted to detect Ki-67 level and apoptosis in xenograft tumor.ResultsDown-regulated miR-145 and up-regulated AKT3 were observed in ESCC tissues and cells. Luciferase reporter assay revealed that miR-145 negatively regulated AKT3 through binding to its 3′-UTR. Overexpression of miR-145 or knockdown of AKT3 promoted DDP-induced cell cycle arrest and apoptosis, as well as reduced IC50 of DDP treatment, which was reversed by AKT3 overexpression. The expression level of MRP1, P-gp, CyclinD1, c-Myc and anti-apoptotic protein Bcl-2 were down-regulated, while pro-apoptotic protein Bax was up-regulated by miR-145. Furthermore, overexpression of miR-145 enhanced the DDP-induced tumor growth suppression in vivo.ConclusionmiR-145 increased the sensitivity of ESCC to DDP, and facilitated DDP-induced apoptosis, cycle arrest by directly inhibiting PI3K/AKT signaling pathway to decrease multidrug resistance-associated proteins MRP1 and P-gp expression. Improving the efficacy of DDP by boosting the miR-145 level provides a new strategy for treatment of ESCC.
Estudo comparativo da dispersão de nanotubos de carbono e sua adição em um cimento endodôntico à base de óxido de zinco e eugenol
Authors: Moreira Danna Mota , Candeiro George Táccio de Miranda , Girão Amanda Leal , Pereira Ricardo Gêneses Bastos , Florêncio Ana Trícia Soeiro 
Published: September 2019

Objetivo: avaliar a durabilidade da dispersão de nanotubos de carbono (NTC) em dodecil sulfato de sódio (SDS) com o intuito de analisar possíveis melhorias no módulo de elasticidade de um cimento endodôntico à base de óxido de zinco e eugenol. Métodos: após a dispersão dos NTC em SDS 2%, 25 μL da solução de NTC+SDS foi adicionada ao cimento Endométhasone N (EMTN). 10 corpos-de-prova foram confeccionados de acordo com os seguintes grupos e tempos após a dispersão (n=10): G1 (Controle): EMTN; G2: EMTN + (NTC+SDS) imediato; G3: EMTN + (NTC+SDS) 24 horas; G4: EMTN + (NTC+SDS) 7 dias e G5: EMTN + (NTC+SDS) 1 mês. As amostras foram submetidas ao teste de flexão de 3-pontos para análise do módulo de elasticidade e os dados foram submetidos à análise estatística. Resultados: não houve diferença significante entre o grupo controle (957,8 ±170 MPa) e o grupo imediato (952,6 ±93,5 MPa) (p>0,05). Já os grupos 24 horas (700,2 ±84,9 MPa) e 7 dias (727,5 ±93 MPa) demonstraram diferença significante em relação ao grupo controle (p<0,05). O grupo 1 mês (545 ±165 MPa) mostrou diferença significante em relação ao grupo controle e ao grupo Imediato (p<0,05). Conclusão: a incorporação de NTC ao cimento Endométhasone N não proporcionou melhorias no módulo de elasticidade quando da sua dispersão imediata ao uso. Entretanto, houve declínio do módulo de elasticidade quando do uso da solução de NTC dispersos em SDS 2% após o período de 24 horas, 7 dias e 1 mês.
Ρήγας και Rétif de la Bretonne. Συμπληρωματικά στοιχεία πάνω σε μια σχέση γνωστή
Authors: Κοντογιάννη Βασιλική 
Published: September 2019

L’étude s’inscrit dans la suite des travaux précédents qui ont abordé la question des rapports entre l’œuvre de Rhigas L’école des amants délicats, publiée en 1790, et l’original français que notre auteur traduit ou plutôt adapte, c’est-à-dire Les Contemporaines de Rétif de la Bretonne, dont la première série a été publiée en 1780. Le but de ce travail est de répondre à un nombre limité d’interrogations complémentaires concernant cette même recherche.Situer Les Contemporaines dans le contexte de la nouvelle française, permet d’apercevoir l’évolution du genre ; cette dernière se reflète de manière significative même dans le livre de Rhigas. Situer Les Contemporaines dans la vie et la créativité de leur auteur, permet de saisir mieux les liens inhérents au choix opéré par Rhigas. Enfin situer Rétif dans le cadre de l’écriture libertine du 18ème siècle, permet de mesurer les distances entre lui et les grands auteurs libertins, comme aussi les distances que Rhigas met entre son écriture et l’original.Si la première partie de l’étude propose une approche contemporaine de l’auteur et de son travail, la deuxième partie tourne le regard vers les choix de Rhigas. Rétif adore et décrit les femmes de la ville de Paris, dans la décennie qui précède la composition ; comment Rhigas arrive-t-il à nous donner un recueil où nous apercevons tout d’abord le jeune homme en tant qu’héros central ? Quelles opérations conduisent à un tel glissement ? Que révèle le titre? Pourquoi les ‘amants délicats’ ? Ces questions tentent de mettre au clair l’œuvre de l’adaptation. Suivant librement son modèle, pour le mettre décidément de côté parfois, Rhigas semble respecter les attitudes de la société grecque pour ce qui est de l’amour et du mariage, tout en essayant d’y apporter quelques améliorations légères mais d’une influence capitale : malgré la différence de classe sociale les héros des nouvelles de Rhigas réussissent (dans la plupart des cas) à atteindre le but, celui d’un mariage heureux. Placée dans le contexte des Lumières grecques cette littérature annonce une ère d’optimisme, celle qui précède l’époque romantique.VASSILIKI KONTOGIANNI
Λογοκρισία και επανάσταση: Η φημολογούμενη έκδοση της Νέας Πολιτικής Διοικήσεως στη Λιψία
Authors: Χατζηπαναγιώτη-Sangmeister Ίλια 
Published: September 2019

Based on unknown documents from German archives, this article details a significant case of prohibitive censorship of a modern greek book during the age of Enlightenment. As the unpublished sources show, the secretary of the Prince of Valachia filed in May 1798, some months after the arrest of Rigas Velestinlis, an official accusation against the Greek merchants in Leipzig for having printed a second edition of Nea Politike Dioikesis – the revolutionary manifest of Rigas. The subsequent investigations ordered and conducted by the saxonian authorities prooved that this accusation was unjustified: Neither the Nea Politike Dioikesis nor any other Greek political text were printed in 1798 in Leipzig. The German documents dissolved the bibliographical phantom of a second edition and allow us to examine the combined intervention: the joined forces of ottoman elites and western-european authorities aimed to prevent the publication and circulation of Greek books with contents considered to be subversive.
The feasibility of implementing an exercise programme for deconditioned cancer survivors in a national cancer centre: FIXCAS Study
Authors: Devenney Kate , Murphy Niamh , Ryan Ronan , Grant Clíona , Kennedy John , Manecksha Rustom P. , Sheils Orla , McNeely Margaret L. , Hussey Juliette , Sheill Grainne 
Published: September 2019

Introduction: As both the number of cancer survivors and the length of survival time are increasing, long-term health issues related to cancer and its treatment are becoming more prevalent. Research suggests that exercise can mitigate several negative health consequences in cancer survivors and improve physical function and quality of life. Multi-modal exercise interventions have been proposed as a cornerstone for survivorship care. However, studies evaluating exercise programmes within the Irish population are lacking. Purpose: To evaluate the introduction, implementation and acceptability of a multi-modal exercise rehabilitation programme for deconditioned cancer survivors in a real-world, standard practice setting. Methods and analysis: In this single-arm prospective feasibility study, cancer survivors (n=40) will undergo a 10-week multi-modal exercise programme. The study population will comprise of cancer survivors attending outpatient services in an Irish national cancer centre. Participants will be aged 18 or older and have completed treatment with curative intent. Feasibility will be evaluated in terms of recruitment, adherence and compliance to the programme. Secondary outcomes will examine physical function and quality of life measures. In addition, the acceptability of the programme will be assessed through patient feedback. Ethics and dissemination: Ethical approval through the St. James’s Hospital and Tallaght University Hospital Research and Ethics Committee is currently pending. The study results will be used to optimise the intervention content and may serve as the foundation for a larger definitive trial. Results will be disseminated through peer-review journals, congresses and relevant clinical groups. Trial registration: ClinicalTrials.gov NCT04026659 (19/07/19)
Performance of Lipoarabinomannan Assay using Cerebrospinal fluid for the diagnosis of Tuberculous meningitis among HIV patients
Authors: Kwizera Richard , Cresswell Fiona V. , Mugumya Gerald , Okirwoth Micheal , Kagimu Enock , Bangdiwala Ananta S. , Williams Darlisha A. , Rhein Joshua , Boulware David R. , Meya David B. 
Published: September 2019

Background: The diagnostic utility of the Mycobacteria tuberculosis lipoarabinomannan (TB-LAM) antigen lateral flow assay on cerebrospinal fluid (CSF) for the diagnosis of tuberculous meningitis (TBM) has not been extensively studied and the few published studies have conflicting results. Methods: Lumbar CSF from 59 HIV-positive patients with suspected TBM was tested with TB-LAM and Xpert MTB/Rif Ultra. The diagnostic performance of CSF TB-LAM was compared to positive CSF Xpert MTB/Rif Ultra (definite TBM) and a composite reference of probable or definite TBM according to the uniform case definition. Results: Of 59 subjects, 12 (20%) had definite TBM and five (9%) had probable TBM. With reference to definite TBM, CSF TB-LAM assay had a diagnostic sensitivity of 33% and specificity of 96%. When compared to a composite reference of definite or probable TBM, the sensitivity was 24% and specificity was 95%. There were two false positive tests with TB-LAM (3+ grade). In-hospital mortality in CSF TB-LAM positive patients was 17% compared to 0% in those with definite TBM by Xpert MTB/Rif Ultra but negative LAM. Conclusions: Lumbar CSF TB-LAM has a poor performance in diagnosing TBM. Both urine TB-LAM and Xpert Ultra should be further investigated in the diagnosis of TBM.
Features of development of sustained fluxes of high-energy gamma-ray emission at different stages of solar flares
Authors: Минасянц Геннадий , Minasyants Gennady , Минасянц Тамара , Minasyants Tamara , Томозов Владимир , Tomozov Vladimir 
Published: September 2019

We have studied properties of sustained gamma fluxes having quantum energies of >100 MeV at different stages of flares with 1-min temporal resolution (Fermi/LAT).
The most probable process of emergence of high-energy gamma-quanta during the impulsive phase of flares (6 events) has been confirmed. Acceleration of particles, produced by flare energy release (at dissipation of current sheet), occurs when they interact with a shock front of a coronal mass ejection (CME), which develops in the same active region at the same time. Nuclear interactions of accelerated protons (>500 MeV) with plasma ions lead further to the emergence of high-energy gamma-quanta. We have established that the interaction between a flare flux and a high-speed CME during the flare impulsive phase occurs within fairly limited periods — from 2 to 16 min. In the events considered, we have found a direct connection between maximum gamma flux F max (γ > 100 MeV) and CME velocity.
High maximum values of gamma fluxes are typical of the flare impulsive phase: 3.5·10⁻⁴ cm⁻²s⁻¹ ≤ F max (γ > 100 MeV) ≤ 1.3·10⁻² cm⁻² s⁻¹. At the same time, the value F max (γ > 100 MeV) = 0.013 cm⁻²s⁻¹ was the highest for the events observed by Fermi/LAT from 2008 to 2017.
During the development of CMEs moving with a supersonic speed, shock waves are formed which are the major power source of accelerated particles during the main phase of gradual flares. In some cases, however, the impact of shock waves on particle acceleration is the greatest in the short impulsive phase.
To reveal parameters most effectively influencing the generation of high-energy gamma-ray emission, we have compared 17 flare events. The most significant parameter proved to be the time interval of joint action of flare process and CME shocks.
We have established that during simultaneous development of flare process and CME attendant on the flare, the most efficient particle acceleration occurs which gives rise to maximum fluxes of high-energy gamma-quanta.
Results of work of new spectropolarimeter for solar radio emission observations in the range 50–500 MHz
Authors: Муратова Наталия , Muratova Nataliia , Муратов Анатолий , Muratov Anatoliy , Кашапова Лариса , Kashapova Larisa 
Published: September 2019

Ground-based observations within meter radio range are of importance for understanding processes occurring in the solar corona.
We present concepts, block diagram, and results of first observations of the Solar Spectropolarimeter of Meter Range (SSMD), launched for solar observations in the range 50–500 MHz in April 2016. The main purpose of this work was to develop an up-to-date digital radio spectropolarimeter able to record the full Stokes vector for sporadic solar phenomena taking place in the 50–500 MHz range.
We use a crossed log periodic antenna to detect solar radio emission. This antenna can simultaneously obtain horizontal and vertical polarization components. The main part of SSMD is a digital receiver based on an FX correlator architecture. We use the Fast Fourier Transform (FFT) algorithm based on the real-time pipeline circuit to construct amplitude dynamic spectra (intensity vs frequency and time).
SSMD has 4608 frequency channels with 97.66 kHz channel bandwidth and 97.66 kHz spacing. Time resolution is 1 s. The spectropolarimeter has a 50–500 MHz range. It can record the full Stokes vector. At present, SSMD observes two of four parameters in regular mode (I and V). We have observational data since 2016. The catalog development is in progress.
We plan to improve time and frequency characteristics, record all Stokes parameters, and conduct a calibration. We are working on providing access to the data archive via the Internet.
OPTIMALISASI KEMAKMURAN MASJID BERBASIS KEMAHASISWAAN DESA MERTELU KECAMATAN GEDANGSARI KABUPATEN GUNUNG KIDUL
Authors: Solihudin Ahmad Rizal , Aditya Luthfi Bagus , Tanjung Ashari , Novera Ijmal 
Published: September 2019

Masjid merupakan salah tempat ibadah umat islam yang wajib dijaga kebersihan dan kenyamanannya. Masjid menjadi sarana titik kumpul dalam suatu acara yang bersifat keilmuan maupun keagamaan, tempat menuntut ilmu dan bertukar ilmu, bertukar pengalaman dan sebagai sarana wisata religi. Program optimalisasi kemakmuran masjid ini merupakan program kerja bersama yang diselenggarakan oleh mahasiswa KKN UAD yang berada di Desa Mertelu Kecamatan Gedangsari. Tujuan dari kegiatan ini adalah untuk menghidupkan kembali masjid yang berada di Desa Mertelu. Metode yang dilakukan dalam program kemakmuran masjid ini adalah dengan 1) menyelenggarakan kegiatan TPA untuk anak-anak Mertelu, 2) melatih anak menyuarakan adzan, 3) melakukan kegiatan sholat berjamaah, Â dan 4) melatih anak-anak untuk menghafal surat pendek dengan doa sehari-hari. Hasil dari optimalisasi kemakmuran masjid ini berupa anak-anak yang semula tidak pernah melakukan kegiatan TPA menjadi antusias untuk mengaji.
Effects of physical activity on long-term survivorship after metal-on-metal hip resurfacing arthroplasty
Authors: Amstutz Harlan C. , Le Duff Michel J. 
Published: September 2019

AimsIn previous studies, we identified multiple factors influencing the survivorship of hip resurfacing arthroplasties (HRAs), such as initial anatomical conditions and surgical technique. In addition, the University of California, Los Angeles (UCLA) activity score presents a ceiling effect, so a better quantification of activity is important to determine which activities may be advisable or detrimental to the recovered patient. We aimed to determine the effect of specific groups of sporting activities on the survivorship free of aseptic failure of a large series of HRA.Patients and MethodsA total of 661 patients (806 hips) representing 77% of a consecutive series of patients treated with metal-on-metal hybrid HRA answered a survey to determine the types and amounts of sporting activities they regularly participated in. There were 462 male patients (70%) and 199 female patients (30%). Their mean age at the time of surgery was 51.9 years (14 to 78). Their mean body mass index (BMI) was 26.5 kg/m2(16.7 to 46.5). Activities were regrouped into 17 categories based on general analogies between these activities. Scores for typical frequency and duration of the sessions were used to quantify the patients’ overall time spent engaging in sporting activities. Impact and cycle scores were computed. Multivariable models were used.ResultsWe found no association between any category of activity and a decrease in survivorship. Impact and hip cycle scores also failed to show any association with revision for aseptic failure or wear.ConclusionReturn to sporting activities after surgery is safe for patients treated with well-designed and well-implanted HRA. Cite this article: Bone Joint J 2019;101-B:1186–1191