bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of high‐intensity resistance circuit‐based training in hypoxia on body composition and strength performance
Authors: Martínez‐Guardado Ismael , Ramos‐Campo Domingo J. , Olcina Guillermo J. , Rubio‐Arias Jacobo A. , Chung Linda H. , Marín‐Cascales Elena , Alcaraz Pedro E. , Timón Rafael 
Published: January 2019

AbstractHypoxic training methods are increasingly being used by researchers in an attempt to improve performance in normoxic ambients. Moreover, previous research suggests that resistance training in hypoxia can cause physiological and muscle adaptations. The primary aim of this study was to compare the effects of 8 weeks of high‐intensity resistance circuit‐based (HRC) training in hypoxia on body composition and strength performance. The secondary aim was to examine the effects of HRC on metabolic parameters. Twenty‐eight male participants were randomly assigned to either hypoxia (Fraction of inspired oxygen [FIO2] = 15%; HRChyp: n = 15; age: 24.6 ± 6.8 years; height: 177.4 ± 5.9 cm; weight: 74.9 ± 11.5 kg) or normoxia [FIO2] = 20.9%; HRCnorm: n = 13; age: 23.2 ± 5.2 years; height: 173.4 ± 6.2 cm; weight: 69.4 ± 7.4 kg) groups. Training sessions consisted of two blocks of three exercises (Block 1: bench press, leg extension and front pull down; Block 2: deadlift, elbow flexion and ankle extension). Each exercise was performed at six repetition maximum. Rest periods lasted for 35‐s between exercises, 3‐min between sets and 5‐min between blocks. Participants exercised twice weekly for 8 weeks, and body composition, strength and blood tests were performed before and after the training program. Lean body mass and bone mineral density significantly increased over time in the HRChyp (p < .005; ES = 0.14 and p < .014; ES = 0.19, respectively) but not in the HRCnorm after training. Both groups improved their strength performance over time (p < .001), but without group effect differences. These results indicate that simulated hypoxia during HRC exercise produced trivial effects on lean body mass and bone mineral density compared to normoxia.
Influence of gas environment and heating on atomic structures of platinum nanoparticle catalysts for proton-exchange membrane fuel cells
Authors: Yoshida Kenta , Zhang Xudong , Shimada Yusuke , Nagai Yasuyoshi , Hiroyama Tomoki , Tanaka Nobuo , Lari Leonardo , Ward Michael R , Boyes Edward D , Gai Pratibha L 
Published: January 2019

Abstract
Atomic-scale relaxations of platinum nanoparticles (Pt NPs) for fuel-cell catalysts are evaluated by spherical-aberration corrected environmental transmission electron microscopy (ETEM) under reference high-vacuum and N2 atmospheres, and then under reactive H2, CO and O2 atmospheres, combined with ex situ durability test using an electrochemical half-cell. In high-vacuum, increasing roughness due to continuous relaxation of surface-adsorbed Pt atoms is quantified in real-space. Under H2 and N2 atmospheres at a critical partial pressure of 1 × 10−2 Pa the stability of the surface facets is for the first time found to be improved. The adsorption behaviour of CO molecules is investigated using experimentally measured Pt–Pt bond lengths on the topmost surface layer of Pt NPs. The deactivation of Pt NPs in the anode environment of a proton-exchange-membrane fuel-cell is demonstrated at the atomic-scale in the ETEM, and the transformation of NPs into disordered nanoclusters is systematically quantified using the partial size distribution of Pt atomic clusters under controlled heating experiments at 423, 573 and 723 K.
Dashing Hopes? the Predictive Accuracy of Domestic Abuse Risk Assessment by Police
Authors: Turner Emily , Medina Juanjo , Brown Gavin 
Published: January 2019

Abstract
The Domestic Abuse, Stalking and Honour Based Violence (DASH) form is a standardized risk assessment implemented across most UK police forces. It is intended to facilitate an officer’s structured professional judgment about the risk a victim faces of serious harm at the hand of their abuser. Until now, it has been an open question whether this tool works in practice. Here, we present the largest scale European study, making the case that the risk assessment tool is underperforming. Each element of the DASH questionnaire is, at best, weakly predictive of revictimization. Officer risk predictions based on DASH are little better than random and a logistic regression model that predicts the same outcome using DASH only provides modest improvement in performance.
Going Spatial: Applying Egohoods to Fear of Crime Research
Authors: Glas Iris , Engbersen Godfried , Snel Erik 
Published: January 2019

Abstract
A central theme in criminology is how fear of crime is influenced by the residential context. Most researchers rely on administrative neighbourhoods to define context. These administrative units do not necessarily align with how inhabitants experience their local surroundings. The present study combines administrative neighbourhoods with a more innovative way to measure context. Using geocoded survey data (N = 14.620) in combination with detailed geographic information system data, we construct egohoods with different radii (ranging from 50 to 750 m). We find that crime, ethnic diversity, economic status, disorder and facilities all have an effect on feelings of unsafety. The contextual effects differ in size and are not detected in all spatial contexts, indicating that it matters how and to which scale data are aggregated.
Histological and MRI Study of the Development of the Human Indusium Griseum
Authors: Bobić Rasonja Mihaela , Orešković Darko , Knezović Vinka , Pogledić Ivana , Pupačić Daniela , Vukšić Mario , Brugger Peter C , Prayer Daniela , Petanjek Zdravko , Jovanov Milošević Nataša 
Published: January 2019

Abstract
To uncover the ontogenesis of the human indusium griseum (IG), 28 post-mortem fetal human brains, 12–40 postconceptional weeks (PCW) of age, and 4 adult brains were analyzed immunohistochemically and compared with post-mortem magnetic resonance imaging (MRI) of 28 fetal brains (14–41 PCW). The morphogenesis of the IG occurred between 12 and 15 PCW, transforming the bilateral IG primordia into a ribbon-like cortical lamina. The histogenetic transition of sub-laminated zones into the three-layered cortical organization occurred between 15 and 35 PCW, concomitantly with rapid cell differentiation that occurred from 18 to 28 PCW and the elaboration of neuronal connectivity during the entire second half of gestation. The increasing number of total cells and neurons in the IG at 25 and 35 PCW confirmed its continued differentiation throughout this period. High-field 3.0 T post-mortem MRI enabled visualization of the IG at the mid-fetal stage using T2-weighted sequences. In conclusion, the IG had a distinct histogenetic differentiation pattern than that of the neighboring intralimbic areas of the same ontogenetic origin, and did not show any signs of regression during the fetal period or postnatally, implying a functional role of the IG in the adult brain, which is yet to be disclosed.
US Guideline Criteria for Human Immunodeficiency Virus Preexposure Prophylaxis: Clinical Considerations and Caveats
Authors: Calabrese Sarah K , Krakower Douglas S , Willie Tiara C , Kershaw Trace S , Mayer Kenneth H 
Published: January 2019

AbstractClinical guidelines for human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) developed by the US Centers for Disease Control and Prevention have been instrumental in the implementation of PrEP in medical practices throughout the country. However, the eligibility criteria contained within may inadvertently limit PrEP access for some patients. We describe the following key considerations and caveats related to these criteria: promotion of a selective vs universal approach to sexual health education involving PrEP; misalignment between criteria stated in the table and text boxes; problematic categorization and confounding of sexual orientation, gender identity, and risk behavior; underemphasis of network/community-level drivers of HIV transmission; oversimplification of serodiscordant risk; and lack of clarity surrounding the relevance of condoms to PrEP eligibility. We offer concrete recommendations to address the identified issues and strengthen future iterations of the guidelines, applying these recommendations in an alternative table of “criteria.”
Epstein-Barr Virus and Monoclonal Gammopathy of Clinical Significance in Autologous Stem Cell Transplantation for Multiple Sclerosis
Authors: Mehra Varun , Rhone Elijah , Widya Stefani , Zuckerman Mark , Potter Victoria , Raj Kavita , Kulasekararaj Austin , McLornan Donal , de Lavallade Hugues , Benson-Quarm Nana , Lim Christina , Ware Sarah , Sudhanva Malur , Malik Omar , Nicholas Richard , Muraro Paolo A , Marsh Judith , Mufti Ghulam J , Silber Eli , Pagliuca Antonio , Kazmi Majid A 
Published: January 2019

AbstractIntroductionAutologous hematopoietic stem cell transplantation (AHSCT) with anti-thymocyte globulin (ATG) conditioning as treatment of active multiple sclerosis (MS) is rapidly increasing across Europe (EBMT registry data 2017). Clinically significant Epstein-Barr virus reactivation (EBV-R) following AHSCT with ATG for severe autoimmune conditions is an underrecognized complication relative to T-cell deplete transplants performed for hematological diseases. This retrospective study reports EBV-R associated significant clinical sequelae in MS patients undergoing AHSCT with rabbit ATG.MethodsRetrospective data were analyzed for 36 consecutive MS-AHSCT patients at Kings College Hospital, London. All patients routinely underwent weekly EBV DNA polymerase chain reaction monitoring and serum electrophoresis for monoclonal gammopathy (MG or M-protein). EBV-R with rising Epstein-Barr viral load, M-protein, and associated clinical sequelae were captured from clinical records.ResultsAll patients had evidence of rising EBV DNA-emia, including 7 who were lost to long-term follow-up, with a number of them developing high EBV viral load and associated lymphoproliferative disorder (LPD). Nearly 72% (n = 18/29) developed de novo MG, some with significant neurological consequences with high M-protein and EBV-R. Six patients required anti-CD20 therapy (rituximab) with complete resolution of EBV related symptoms. Receiver operating characteristics estimated a peak EBV viremia of >500 000 DNA copies/mL correlated with high sensitivity (85.5%) and specificity (82.5%) (area under the curve: 0.87; P = .004) in predicting EBV-R related significant clinical events.ConclusionSymptomatic EBV reactivation increases risk of neurological sequelae and LPD in MS-AHSCT. We recommend regular monitoring for EBV and serum electrophoresis for MG in MS patients in the first 3 months post-AHSCT.
Risk of Latent Tuberculosis Reactivation After Hematopoietic cell Transplantation
Authors: Cheng Matthew P , Kusztos Amanda E , Bold Tyler D , Ho Vincent T , Glotzbecker Brett E , Hsieh Candace , Baker Meghan A , Baden Lindsey R , Hammond Sarah P , Marty Francisco M 
Published: January 2019

Abstract
There were no cases of tuberculosis in a cohort of 2531 patients who underwent hematopoietic cell transplantation from 2010 to 2015 after 7323 person-years of follow up (95% confidence interval [CI], 0.0–0.05 cases/100 person-years), including 29 (1.15%) patients with untreated latent tuberculosis after 89 person-years of follow-up (95% CI, 0.0–4.06 cases/100 person-years).
Gardnerella vaginalis and Prevotella bivia Trigger Distinct and Overlapping Phenotypes in a Mouse Model of Bacterial Vaginosis
Authors: Gilbert Nicole M , Lewis Warren G , Li Guocai , Sojka Dorothy K , Lubin Jean Bernard , Lewis Amanda L 
Published: January 2019

AbstractBackgroundBacterial vaginosis (BV) is a common imbalance of the vaginal microbiota characterized by overgrowth of diverse Actinobacteria, Firmicutes, and Gram-negative anaerobes. Women with BV are at increased risk of secondary reproductive tract infections and adverse pregnancy outcomes. However, which specific bacteria cause clinical features of BV is unclear.MethodsWe previously demonstrated that Gardnerella vaginalis could elicit many BV features in mice. In this study, we established a BV model in which we coinfected mice with G. vaginalis and another species commonly found in women with BV: Prevotella bivia.ResultsThis coinfection model recapitulates several aspects of human BV, including vaginal sialidase activity (a diagnostic BV feature independently associated with adverse outcomes), epithelial exfoliation, and ascending infection. It is notable that G. vaginalis facilitated uterine infection by P. bivia.ConclusionsTaken together, our model provides a framework for advancing our understanding of the role of individual or combinations of BV-associated bacteria in BV pathogenesis.
Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi
Authors: Bennett Aisleen , Pollock Louisa , Jere Khuzwayo C , Pitzer Virginia E , Lopman Benjamin , Parashar Umesh , Everett Dean , Heyderman Robert S , Bar-Zeev Naor , Cunliffe Nigel A , Iturriza-Gomara Miren 
Published: January 2019

Abstract
Horizontal transmission of rotavirus vaccine virus may contribute to indirect effects of rotavirus vaccine, but data are lacking from low-income countries. Serial stool samples were obtained from Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8, and 10 after vaccination) and from their household contacts (8–10 days after vaccine). RV1 vaccine virus in stool was detected using semiquantitative real-time reverse-transcription polymerase chain reaction. RV1 fecal shedding was detected in 41 of 60 vaccinated infants (68%) and in 2 of 147 household contacts (1.4%). Horizontal transmission of vaccine virus within households is unlikely to make a major contribution to RV1 indirect effects in Malawi.
Effects of time of feeding during gestation on sow’s performance1
Authors: Manu Hayford , Lee Su H , Ren Ping , Pangeni Devi , Yang Xiaojian , Baidoo Samuel K 
Published: January 2019

Abstract
The aim of this study was to investigate the effect of different feeding time regimes given similar energy intake per kilogram live BW0.75 during gestation on sow’s performance. One hundred and seventy-four sows [Topigs TN 70 (Landrace × Large White, Topigs USA); parity 3.81 ± 0.16; initial BW = 211.57 ± 3.34 kg; backfat (BF) 13.70 ± 0.42 mm] were blocked by parity, farrowing date, balanced for BW and randomly assigned to 1 of 3 treatments in a randomized complete block design. Treatments included sows fed corn-soybean meal-based diet once at [0730 (control, T1), 1130 (T2), or 1530 h (T3)], with daily feed quantity kept at 1.25× maintenance energy intake [100 × (BW)0.75] kcal ME/d. Sows received 6,758, 7,434, and 8,110 kcal ME/d from days 30 to 60, days 61 to 90, days 91 to 109 of gestation, respectively. The gestation diet was formulated to contain 3,379 kcal of ME/kg, 0.70% Ca, 0.61% total P, 0.58% SID Lys, 0.26% SID Met, 0.45% SID Thr, 0.12% SID Trp, and 0.48% SID Met+Cys. Body weight and BF were recorded on days 30, 60, 90, and 109 of gestation, 24 h after farrowing and at weaning. Results showed that feeding times evaluated did not alter BW changes from day 30 to day 109 of gestation (P = 0.81) or from day 30 to weaning (P = 0.87). Similarly, feeding sows daily at 1130 h did not influence BF gains and sow reproductive performance relative to the control sows (P &gt; 0.10). Sows fed once daily at 1530 h gained more BF compared with the control (3.69 ± 0.47 vs. 2.12 ± 0.50 mm, P = 0.04) from day 30 to day 109 of gestation. From day 30 of gestation to weaning, treatments did not influence BF gain (P = 0.24). Feeding sows daily meal at 1530 h had propensity to increase (P = 0.09) the number of piglets weaned by 0.54 piglets compared with the control sows. In conclusion, the present study demonstrated that feeding pregnant sows at 1530 h altered energy and nutrient metabolism improving their BF gain and exhibited a potential to increase the number of weaned piglets compared with conventional feeding regime.
Development of Common Data Elements for Use in Chiari Malformation Type I Clinical Research: An NIH/NINDS Project
Authors: Luciano Mark G , Batzdorf Ulrich , Kula Roger W , Rocque Brandon G , Maher Cormac O , Heiss John , Martin Bryn A , Bolognese Paolo A , Ashley-Koch Allison , Limbrick David , Poppe Dorothy J , Esposito Kaitlyn M , Odenkirchen Joanne , Esterlitz Joy R , Ala’i Sherita , Joseph Kristen , Feldman Robin S , Riddle Robert ,   Chiari I Malformation Common Data Element Working Group
Published: January 2019

ABSTRACT
The management of Chiari I malformation (CMI) is controversial because treatment methods vary and treatment decisions rest on incomplete understanding of its complex symptom patterns, etiologies, and natural history. Validity of studies that attempt to compare treatment of CMI has been limited because of variable terminology and methods used to describe study subjects. The goal of this project was to standardize terminology and methods by developing a comprehensive set of Common Data Elements (CDEs), data definitions, case report forms (CRFs), and outcome measure recommendations for use in CMI clinical research, as part of the CDE project at the National Institute of Neurological Disorders and Stroke (NINDS) of the US National Institutes of Health. A working group, comprising over 30 experts, developed and identified CDEs, template CRFs, data dictionaries, and guidelines to aid investigators starting and conducting CMI clinical research studies. The recommendations were compiled, internally reviewed, and posted online for external public comment. In October 2016, version 1.0 of the CMI CDE recommendations became available on the NINDS CDE website. The recommendations span these domains: Core Demographics/Epidemiology; Presentation/Symptoms; Co-Morbidities/Genetics; Imaging; Treatment; and Outcome. Widespread use of CDEs could facilitate CMI clinical research trial design, data sharing, retrospective analyses, and consistent data sharing between CMI investigators around the world. Updating of CDEs will be necessary to keep them relevant and applicable to evolving research goals for understanding CMI and its treatment.
Conforming Choices: Peer Influence, Adoption, and Interpretation of the Islamic Headscarf in Indonesia
Authors: Brown Gustav 
Published: January 2019

AbstractThis article examines the role of peer influence in structuring adoption and interpretation of the Islamic headscarf among young Muslim women in Indonesia. I argue that approaches to the jilbab fall into two broad-based categories of practice, each of whose practitioners play distinct roles in the social process driving both adoption and interpretation of the headscarf. Proactively pious Muslims act as “influencers” who encourage adoption by morality signaling (i.e., signaling “virtue” and “correct-ness” to others) in the immediate social environment. The reactively pious adopt the practice in response to the internalized urge to conform to new expectations within a pietized field, but then transform the practice by treating it as a commodified element in broader repertoires of fashion and femininity. The result is both a pietized social field and one in which piety has been informalized.
Immediate Use of Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnea Following Transsphenoidal Pituitary Surgery: A Case Series
Authors: Rieley William , Askari Ayda , Akagami Ryojo , Gooderham Peter A. , Swart Petrus A. , Flexman Alana M. 
Published: January 2019

Background:
Patients who undergo transsphenoidal pituitary resection have an elevated risk of obstructive sleep apnea (OSA) yet their outcomes and the safety of continuous positive airway pressure (CPAP) remains unclear. Our study objective was to determine the incidence of complications related to the use of early positive airway pressure following pituitary resection.

Methods:
We retrospectively identified all patients who underwent endoscopic transsphenoidal pituitary tumor resection between January 1, 2005 and March 24, 2016 at our institution, including those with diagnosed or suspected OSA. We compared characteristics and postoperative complications of OSA patients who did and did not receive CPAP postoperatively.

Results:
In total, 427 patients underwent transsphenoidal pituitary resection. Of these, 64 (15%) had OSA. Acromegaly was more common in patients with OSA (42% vs. 10%; P<0.001) but not Cushing Disease (19% vs. 16%; P=0.54). Hypoxia was more common in patients with OSA as compared to those without (14% vs. 5%; P<0.001) and one patient with OSA was reintubated compared with none in the control group (P=0.017). Eight patients had CPAP applied in the immediate postoperative period and the incidence of postoperative cerebrospinal fluid (CSF) leak, infection, and pneumocephalus was similar between OSA patients with and without CPAP.

Discussion:
Our case series of patients with OSA who received CPAP immediately following transsphenoidal pituitary resection resulted in similar rates of surgical complications. Our results support further investigation to establish the safety of CPAP in this population.
BRAF Inhibitor–Associated Granulomatous Dermatitis: A Report of 3 Cases
Authors: Hui Ong Eugene Liat , Sinha Rishika , Jmor Shilan , Fearfield Louise 
Published: January 2019

Abstract:
Cutaneous toxicities associated with BRAF inhibitor treatment in patients with metastatic melanoma have been well described. We present a rare association of granulomatous dermatitis in association with the BRAF inhibitor vemurafenib. Three patients with metastatic melanoma all presented with asymptomatic papular eruptions 8–21 months into vemurafenib therapy. Skin biopsies confirmed the diagnosis of granulomatous dermatitis. Other causes of granulomatous dermatitis including infectious agents and sarcoid were excluded. Treatment with potent topical and oral steroids improved the eruptions, but only after the cessation of vemurafenib did all 3 cases of granulomatous dermatitis completely resolve within 2 weeks. It is important to recognize that this association, unlike most other BRAF inhibitor–related skin toxicities, can occur many months after commencement of therapy and that vemurafenib treatment can be continued without clinically significant adverse effects.