bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention
Authors: SATİLMİSOGLU Muhammet Hulusi , GUL Mehmet , CAKMAK Huseyin Altug , ISİKSACAN Nilgun , TUREN Selahattin , KOKTURK Ugur , YİLMAZ Emre , KARAKAYALI Muammer , TOSU Aydin Rodi 
Published: December 2018

Objective:
Vitamin-D status is very important for optimal function of human body
especially cardiovascular system. The aim of this study was to investigate the
long term prognostic value of admission vitamin D level in acute ST-segment
elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary
intervention (PPCI).

Methods:
One hundred fifty seven consecutive patients, who were admitted to a training
and research hospital with a diagnosis of STEMI and underwent PPCI, were
recruited in this prospective study. The study patients were divided into 2
groups according to their vitamin-D levels as follows: High vitamin-D group
(n=80) and Low vitamin-D group (n=77). The severity of coronary artery disease
(CAD) was assessed with calculation of the SYNTAX score.

Results:
There were significant negative correlations between Vitamin-D level and SYNTAX
score, serum glucose, and gender, but a positive correlation with hemoglobin
level. Cardiovascular mortality was found to be significantly higher in the low
vitamin-D group as compared to the high group (p&lt;0.001). In multivariate
analysis, low vitamin-D level was found as a significant independent predictor
of long term cardiovascular mortality after adjusting for other risk factors.

Conclusion:
We demonstrated that low admission vitamin-D is related to severity of CAD.
Vitamin-D deficiency is an independent predictor for long term cardiovascular
mortality in acute STEMI undergoing PPCI.
Çocukluk Çağında Atipik Hemolitik Üremik Sendrom
Authors: KARA Mehtap Akbalık , DEMİRCİOĞLU KILIÇ Beltinge 
Published: December 2018

Atipik hemolitik üremik sendrom,
alternatif komplemanın yolunun kronik kontrolsüz aktivasyonundan ortaya çıkan
trombotik mikroanjiyopatinin nadir bir şeklidir. Atipik hemolitik üremik
sendrom, immün olmayan hemolitik anemi, trombositopeni ve böbrek tutulumu ile
ilişkilidir. Hastalık akut dönemde mortalite ve morbiditeye ve uzun dönemde son
dönem böbrek yetmezliğine neden olabilir. Hastalıkta her ne kadar böbrek
tutulumu görülse de, vakaların % 20'sinde ekstra-renal tutulum görülebilir.
Tanı konan hastalarda genetik çalışma yapılmalı böbrek fonksiyonlarının
korunması ve hematolojik remisyon sağlanması için hızla tedavi başlanmalıdır.
Tanıdan sonraki ilk 24 saatte birinci basamak tedavi olarak taze donmuş plazma
ile plazmaferez tedavisi başlanmalıdır, gereklilik durumunda ekuluzimab
tedavisine geçilmelidir. Son dönem böbrek yetmezliği gelişmiş olgularda
karaciğer veya karaciğer- böbrek nakli ekuluzimab tedavisi ile birlikte
planlanabilir.&nbsp;
Fallgirls: Gender and the Framing of Torture at Abu Ghraib (Classical and Contemporary Social Theory), by Ryan Ashley Caldwell
Authors: Pérez Sales Pau 
Published: December 2018

Initially published in 2012 and now reedited, this book constitutes a peculiar contribution to the torture literature on perpetrators. Existing books have already covered: self-justifying perspectives written by perpetrators (i.e. Aussaresses, 2010; Moore-King, 1998; Pardo, 2014; Troccoli, 1996); interviews with perpetrators or analysis from autobiographical texts (i.e. Conroy, 2000; Crelinsten & Schmid, Alex P (Eds.), 1995; Haritos-Fatouros, 2003; Payne, 2008; Pérez-Sales, 2017); and analysis of the interaction from a survivor’s viewpoint (Gil, 1999). There also exists a wealth of social psychology books that attempt to theorize the logic and dynamics of becoming a perpetrator (i.e. Bandura, Barbaranelli, Caprara, & Pastorelli, 1996; Browning, 1992; Miller, 2004; Staub, 1999). Caldwell’s book adopts the extreme hypothesis that the soldiers England and Harman, judged for acts of misconduct in Abu Ghraib after the leakage of dozens of terrible pictures, are innocent. The book goes on to defend the nearly untenable thesis that England and Harman must be considered victims themselves. It is thus wholly unsurprising to find out that Caldwell was part of the legal defence team for both soldiers.
ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma
Authors: Oria Victor O. , Lopatta Paul , Schmitz Tatjana , Preca Bogdan‐Tiberius , Nyström Alexander , Conrad Catharina , Bartsch Jörg W. , Kulemann Birte , Hoeppner Jens , Maurer Jochen , Bronsert Peter , Schilling Oliver 
Published: December 2018

A disintegrin and a metalloprotease (ADAM)‐9 is a metzincin cell‐surface protease with strongly elevated expression in solid tumors, including pancreatic ductal adenocarcinoma (PDAC). In this study, we performed immunohistochemistry (IHC) of a tissue microarray (TMA) to examine the expression of ADAM9 in a cohort of >100 clinically annotated PDAC cases. We report that ADAM9 is prominently expressed by PDAC tumor cells, and increased ADAM9 expression levels correlate with poor tumor grading (P = 0.027) and the presence of vasculature invasion (P = 0.017). We employed gene expression silencing to generate a loss‐of‐function system for ADAM9 in two established PDAC cell lines. In vitro analysis showed that loss of ADAM9 does not impede cellular proliferation and invasiveness in basement membrane. However, ADAM9 plays a crucial role in mediating cell migration and adhesion to extracellular matrix substrates such as fibronectin, tenascin, and vitronectin. This effect appears to depend on its catalytic activity. In addition, ADAM9 facilitates anchorage‐independent growth. In AsPC1 cells, but not in MiaPaCa‐2 cells, we noted a pronounced yet heterogeneous impact of ADAM9 on the abundance of various integrins, a process that we characterized as post‐translational regulation. Sprout formation of human umbilical vein endothelial cells (HUVECs) is promoted by ADAM9, as examined by transfer of cancer cell conditioned medium; this finding further supports a pro‐angiogenic role of ADAM9 expressed by PDAC cancer cells. Immunoblotting analysis of cancer cell conditioned medium highlighted that ADAM9 regulates the levels of angiogenic factors, including shed heparin‐binding EGF‐like growth factor (HB‐EGF). Finally, we carried out orthotopic seeding of either wild‐type AsPC‐1 cells or AsPC‐1 cells with silenced ADAM9 expression into murine pancreas. In this in vivo setting, ADAM9 was also found to foster angiogenesis without an impact on tumor cell proliferation. In summary, our results characterize ADAM9 as an important regulator in PDAC tumor biology with a strong pro‐angiogenic impact.
Phenoptosis and the Evolution of Ageing
Authors: Walker Richard F 
Published: December 2018

AbstractPhenoptosis describes ageing as the evolved product of a genome‐based program to limit lifespan and thereby favour evolution. Previously, programmed ageing was deemed incompatible with Darwinian dogma that population evolution depends upon genetic diversity resulting from selection of traits that provide individual benefit. To avoid this conflict, phenoptosis employs evolvability, an alternative theory of evolution through which biological systems can acquire novel functions that enhance population evolution without individual benefit. This article analyses the claim that ‘programmed’ ageing evolved de novo, specifically to limit lifespan exclusively under the cloak of evolvability, and if certain assumptions in phenoptosis theory are valid. A brief historic perspective of its origins will be followed by considerations of ‘when’, ‘why’ and ‘how’ it evolved. An alternative ‘programmatic’ theory that presents a mechanism for the coincidental evolution of ageing with the developmental program will be compared and contrasted with phenoptosis.Key ConceptsIndividual benefit is incompatible with phenoptosis (programmed ageing) theory, but compatible with development/ageing continuum (programmatic ageing) theory.Immortal/nonageing animals preceded the evolution of phenoptosis.Phenoptosis relies exclusively upon ‘evolvability’ to explain the evolution of ageing, yet ageing promotes ‘evolvability’ thereafter.In nonsenescing populations (presumably existing before phenoptosis), evolution would be stifled by low adult death rate.Natural selection in immortal populations causes unchecked birth rates, overpopulation and subsequent extinctions. Phenoptosis then emerges as an adaptation.Phenoptosis evolved by the process of ‘supra‐individual’ selection.Selection for ecological homeostasis counterbalances selection for expanding individual reproductive fitness and keeps growth rates in check.Scheduled death increases individual turnover, provides more chances for evolution of diverse genotypes and thereby, increases evolvability.Programmatic ageing is a product of coincidental evolution resulting from post‐maturational decay of the developmental program and of second‐order selection for population benefit.Ageing is initiated and accelerated by progressive loss of temporal organisation within the whole organism, not by any individual or few factors affecting single metabolic or physiologic functions.
Sliding mode disturbance observer control based on adaptive synchronization in a class of fractional‐order chaotic systems
Authors: Mofid Omid , Mobayen Saleh , Khooban Mohammad‐Hassan 
Published: December 2018

SummaryIn this paper, a fractional‐order Dadras‐Momeni chaotic system in a class of three‐dimensional autonomous differential equations has been considered. Later, a design technique of adaptive sliding mode disturbance‐observer for synchronization of a fractional‐order Dadras‐Momeni chaotic system with time‐varying disturbances is presented. Applying the Lyapunov stability theory, the suggested control technique fulfils that the states of the fractional‐order master and slave chaotic systems are synchronized hastily. While the upper bounds of disturbances are unknown, an adaptive regulation scheme is advised to estimate them. The recommended disturbance‐observer realizes the convergence of the disturbance approximation error to the origin. Finally, simulation results are presented in one example to demonstrate the efficiency of the offered scheme on the fractional‐order Dadras‐Momeni chaotic system in the existence of external disturbances.
Monothiatruxene‐Based, Solution‐Processed Green, Sky‐Blue, and Deep‐Blue Organic Light‐Emitting Diodes with Efficiencies Beyond 5% Limit
Authors: Maciejczyk Michal R. , Zhang Shuyu , Hedley Gordon J. , Robertson Neil , Samuel Ifor D. W. , Pietraszkiewicz Marek 
Published: December 2018

AbstractThe development of blue materials with good efficiency, even at high brightness, with excellent color purity, simple processing, and high thermal stability assuring adequate device lifetime is an important remaining challenge for organic light‐emitting didoes (OLEDs) in displays and lightning applications. Furthermore, these various features are typically mutually exclusive in practice. Herein, four novel green and blue light‐emitting materials based on a monothiatruxene core are reported together with their photophysical and thermal properties, and performance in solution‐processed OLEDs. The materials show excellent thermal properties with high glass transition temperatures ranging from 171 to 336 °C and decomposition temperatures from 352 to 442 °C. High external quantum efficiencies of 3.7% for a deep‐blue emitter with CIE color co‐ordinates (0.16, 0.09) and 7% for green emitter with color co‐ordinates (0.22, 0.40) are achieved at 100 cd m−2. The efficiencies observed are exceptionally high for fluorescent materials with photoluminescence quantum yields of 24% and 62%, respectively. The performance at higher brightness is very good with only 38% and 17% efficiency roll‐offs at 1000 cd m−2. The results indicate that utilization of this unique molecular design is promising for efficient deep‐blue highly stable and soluble light‐emitting materials.
4D Biomaterials for Light‐Guided Angiogenesis
Authors: Farrukh Aleeza , Paez Julieta I. , del Campo Aránzazu 
Published: December 2018

AbstractA strategy for spatial and temporal regulation of ligand presentation within a biomaterial, and the consequent site‐ and time‐specific cellular responses in 4D cell cultures are presented. The key molecular component is a light‐activatable adhesive peptidomimetic (cyclo Arg‐Gly‐Asp‐phe‐Cys, RGDfC) modified with the two‐photon photocleavable group (p‐methoxynitrobiphenyl, PMNB) used to functionalize a hydrogel. A scanning laser at 740 nm defines the 4D presentation of active RGD ligands within the gel, and directs basic cellular processes of embedded cells in situ. The excellent photochemical properties of the PMNB photoremovable group allows direct photomanipulation of the cellular environment without appreciable damage of the embedded cells. Light‐directed migration of fibroblasts within a crosslinked poly(ethylene glycol) (PEG) hydrogel, and sequential, light‐regulated angiogenesis with human umbilical vein endothelial cells (HUVECs) in 4D constructs is demonstrated. The materials presented here represent unique microenvironments to reconstruct dynamic changes in the composition of the extracellular space of cells that occur in in vivo tissues.
Study of the Interface of the Early Stages of Growth under Quasi‐Equilibrium Conditions of ZnO on Graphene/Cu and Graphite
Authors: Morales Carlos , Black Andrés , Urbanos Fernando J. , Granados Daniel , Méndez Javier , del Campo Adolfo , Yubero Francisco , Soriano Leonardo 
Published: December 2018

AbstractThe study of the early stages of growth of ZnO on graphene supported on Cu and on highly oriented pyrolytic graphite by means of reactive thermal evaporation of metallic Zn at room temperature is presented. This growth method allows to go in depth in the study of the fundamental interaction between ZnO and graphene at the interface in quasi‐equilibrium conditions. Quantitative, chemical, and morphological analysis is performed using photoemission spectroscopy, atomic force, and scanning microscopies as experimental characterization techniques and factor analysis and inelastic peak shape analysis as modeling techniques. The growth of ZnO on a highly oriented pyrolytic graphite substrate is also studied using the same growth method for comparison. The results show that, in spite that the first atomic layer of both substrates is identical, the growth kinetics and morphology of the deposits are completely different. A model for the kinetics of the growth of ZnO on both substrates is proposed.
Grafting Benzenediazonium Tetrafluoroborate onto LiNixCoyMnzO2 Materials Achieves Subzero‐Temperature High‐Capacity Lithium‐Ion Storage via a Diazonium Soft‐Chemistry Method
Authors: Sun Zhonghui , Li Zheng , Gao Lifang , Zhao Xin , Han Dongxue , Gan Shiyu , Guo Shaojun , Niu Li 
Published: December 2018

AbstractSubzero‐temperature Li‐ion batteries (LIBs) are highly important for specific energy storage applications. Although the nickel‐rich layered lithium transition metal oxides(LiNixCoyMnzO2) (LNCM) (x > 0.5, x + y +z = 1) are promising cathode materials for LIBs, their very slow Li‐ion diffusion is a main hurdle on the way to achieve high‐performance subzero‐temperature LIBs. Here, a class of low‐temperature organic/inorganic hybrid cathode materials for LIBs, prepared by grafting a conducting polymer coating on the surface of 3 µm sized LiNi0.6Co0.2Mn0.2O2 (LNCM‐3) material particles via a greener diazonium soft‐chemistry method is reported. Specifically, LNCM‐3 particles are uniformly coated with a thin polyphenylene film via the spontaneous reaction between LNCM‐3 and C6H5N2+BF4−. Compared with the uncoated one, the polyphenylene‐coated LNCM‐3 (polyphenylene/LNCM‐3) has shown much improved low‐temperature discharge capacity (≈148 mAh g−1 at 0.1 C, −20 °C), outstanding rate capability (≈105 mAh g−1 at 1 C, −20 °C), and superior low‐temperature long‐term cycling stability (capacity retention is up to 90% at 0.5 C over 1150 cycles). The low‐temperature performance of polyphenylene/LNCM‐3 is the best among the reported state‐of‐the art cathode materials for LIBs. The present strategy opens up a new avenue to construct advanced cathode materials for wider range applications.
High Power Factors of Thermoelectric Colusites Cu26T2Ge6S32 (T = Cr, Mo, W): Toward Functionalization of the Conductive “Cu–S” Network
Authors: Pavan Kumar Ventrapati , Supka Andrew R. , Lemoine Pierric , Lebedev Oleg I. , Raveau Bernard , Suekuni Koichiro , Nassif Vivian , Al Rahal Al Orabi Rabih , Fornari Marco , Guilmeau Emmanuel 
Published: December 2018

AbstractThe introduction of hexavalent T6+ cations in p‐type thermoelectric colusites Cu26T2Ge6S32 (T = Cr, Mo, W) leads to the highest power factors among iono‐covalent sulfides, ranging from 1.17 mW m−1 K−2 at 700 K for W to a value of 1.94 mW m−1 K−2 for Cr. In Cu26Cr2Ge6S32, ZT reaches values close to unity at 700 K. The improvement of the transport properties in these new sulfides is explained on the basis of electronic structure and transport calculations keeping in mind that the relaxation time is significantly influenced by the size and the electronegativity of the interstitial T cation. The rationale is based on the concept of a conductive “Cu–S” network, which in colusites corresponds to the more symmetric parent structure sphalerite. A detailed structural analysis of these colusites shows that the distortion of the conductive network is influenced by the presence in the structure of mixed octahedral–tetrahedral [TS4]Cu6 complexes where the T cations are underbonded to sulfur and form metal–metal interactions with copper, Cu–T distances decreasing from 2.76 Å for W to 2.71 Å for Cr. The interactions between these complexes are responsible for the outstanding electronic transport properties. By contrast, the thermal conductivity is not significantly affected.
Assessment of physical fitness and its correlates in Chinese children and adolescents in Shanghai using the multistage 20‐M shuttle‐run test
Authors: Zou Zhichun , Chen Peijie , Yang Yang , Xiao Mouyuan , Wang Zhijie 
Published: December 2018

AbstractObjectiveThe aim of this study was to evaluate the effectiveness of a multistage 20‐m shuttle‐run test (20‐m SRT) in assessing the physical fitness of Chinese children and adolescents in Shanghai.MethodsA total of 4833 children and adolescents (2437 males and 2396 females, aged 7–17 years) were enrolled in this study. Height, weight, body fat percentage, fat‐free mass, BMI, and skinfold thickness were measured or calculated. The participants were randomly grouped for performing the 20‐m SRT. The maximal oxygen uptake (VO2max and VO2max/kg) was estimated from the 20‐m SRT using the model of Leger et al.ResultsAll the measured and calculated parameters (age, height, weight, body fat percentage, fat‐free mass, BMI, skinfold thickness, and the results of the 20‐m SRT, as well as the estimated VO2max and VO2max/kg) had significant correlations with each other (P < .05). The multiple regression analyses indicated that (1) results of the 20‐m SRT were significantly associated with age, sex, height, and fat‐free mass (P < .05); (2) VO2max/kg was significantly associated with sex, age, weight, BMI, fat‐free mass, and skinfold thickness (P < .001); and (3) VO2max was markedly associated with sex, age, height, weight, BMI, fat‐free mass, and skinfold thickness (P < .001). There were differences between males and females in the results of multiple regression analyses.ConclusionsResults of the 20‐m SRT and the estimated VO2max and VO2max/kg from the 20‐m SRT can be used for evaluating the physical fitness of children and adolescents in Shanghai. Gender may be a factor affecting the effectiveness of the 20‐m SRT.
Sex selection in late Iberian infant burials: Integrating evidence from morphological and genetic data
Authors: Afonso Cristina , Nociarova Dominika , Santos Cristina , Martinez‐Labarga Cristina , Mestres Imma , Duran Montserrat , Malgosa Assumpció 
Published: December 2018

AbstractObjectiveThe aim of this study was to analyze the infant burials found inside Iberian homes in relation to a possible case of sex selection.MethodsThe study included the remains of 11 infant individuals buried under the 10 houses excavated in the late Iberian village of Camp de les Lloses (Tona, Barcelona, Spain). Sex was determined using genetic analysis.ResultsOur results showed that almost all the burials were females. However, the age interval of death was wide enough to weaken the premise of infanticide, and the burials probably represent cases of natural death.DiscussionInfanticide in its different forms has long been argued as an explanation for the infant remains found throughout various burial sites. Many authors thought that infanticide, mainly femicide, was the main method of population control in ancient times. However, there is no anthropological evidence (age distribution and sex analyzed genetically) to support the intentional killing of females in this or in other cases. We hypothesized that there was a positive selection for females to be buried inside the houses, probably related to their benefactor roles.
Regulation of Protein Activity and Cellular Functions Mediated by Molecularly Evolved Nucleic Acids
Authors: Tan Jie , Zhao Mengmeng , Wang Jie , Li Zhihao , Liang Ling , Zhang Liqin , Yuan Quan , Tan Weihong 
Published: December 2018

AbstractRegulation of protein activity is essential for revealing the molecular mechanisms of biological processes. DNA and RNA achieve many uniquely efficient functions, such as genetic expression and regulation. The chemical capability to synthesize artificial nucleotides can expand the chemical space of nucleic acid libraries and further increase the functional diversity of nucleic acids. Herein, a versatile method has been developed for modular expansion of the chemical space of nucleic acid libraries, thus enabling the generation of aptamers able to regulate protein activity. Specifically, an aptamer that targets integrin alpha3 was identified and this aptamer can inhibit cell adhesion and migration. Overall, this chemical‐design‐assisted in vitro selection approach enables the generation of functional nucleic acids for elucidating the molecular basis of biological activities and uncovering a novel basis for the rational design of new protein‐inhibitor pharmaceuticals.
Quantifying the Initial Unfolding of Bacteriorhodopsin Reveals Retinal Stabilization
Authors: Yu Hao , Heenan Patrick R. , Edwards Devin T. , Uyetake Lyle , Perkins Thomas T. 
Published: December 2018

AbstractThe forces that stabilize membrane proteins remain elusive to precise quantification. Particularly important, but poorly resolved, are the forces present during the initial unfolding of a membrane protein, where the most native set of interactions is present. A high‐precision, atomic force microscopy assay was developed to study the initial unfolding of bacteriorhodopsin. A rapid near‐equilibrium folding between the first three unfolding states was discovered, the two transitions corresponded to the unfolding of five and three amino acids, respectively, when using a cantilever optimized for 2 μs resolution. The third of these states was retinal‐stabilized and previously undetected, despite being the most mechanically stable state in the whole unfolding pathway, supporting 150 pN for more than 1 min. This ability to measure the dynamics of the initial unfolding of bacteriorhodopsin provides a platform for quantifying the energetics of membrane proteins under native‐like conditions.