bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced deformability contributes to impaired deoxygenation‐induced ATP release from red blood cells of older adult humans
Authors: Racine Matthew L. , Dinenno Frank A. 
Published: July 2019

Key points
Red blood cells (RBCs) release ATP in response to deoxygenation, which can increase blood flow to help match oxygen supply with tissue metabolic demand.
This release of ATP is impaired in RBCs from older adults, but the underlying mechanisms are unknown.
In this study, improving RBC deformability in older adults restored deoxygenation‐induced ATP release, whereas decreasing RBC deformability in young adults reduced ATP release to the level of that of older adults.
In contrast, treating RBCs with a phosphodiesterase 3 inhibitor did not affect ATP release in either age group, possibly due to intact intracellular signalling downstream of deoxygenation as indicated by preserved cAMP and ATP release responses to pharmacological Gi protein activation in RBCs from older adults.
These findings are the first to demonstrate that the age‐related decrease in RBC deformability is a primary mechanism of impaired deoxygenation‐induced ATP release, which may have implications for treating impaired vascular control with advancing age.
AbstractIn response to haemoglobin deoxygenation, red blood cells (RBCs) release ATP, which binds to endothelial purinergic receptors and stimulates vasodilatation. This ATP release is impaired in RBCs from older vs. young adults, but the underlying mechanisms are unknown. Using isolated RBCs from young (24 ± 1 years) and older (65 ± 2 years) adults, we tested the hypothesis that age‐related changes in RBC deformability (Study 1) and cAMP signalling (Study 2) contribute to the impairment. RBC ATP release during normoxia ( ∼112 mmHg) and hypoxia ( ∼20 mmHg) was quantified with the luciferin–luciferase technique following RBC incubation with Y‐27632 (Rho‐kinase inhibitor to increase deformability), diamide (cell‐stiffening agent), cilostazol (phosphodiesterase 3 inhibitor), or vehicle control. The mean change in RBC ATP release from normoxia to hypoxia in control conditions was significantly impaired in older vs. young (∼50% vs. ∼120%; P < 0.05). RBC deformability was also lower in older vs. young as indicated by a higher RBC transit time (RCTT) measured by blood filtrometry (RCTT: 8.541 ± 0.050 vs. 8.234 ± 0.098 a.u., respectively; P < 0.05). Y‐27632 improved RBC deformability (RCTT: 8.228 ± 0.083) and ATP release (111.7 ± 17.2%) in older and diamide decreased RBC deformability (RCTT: 8.955 ± 0.114) and ATP release (67.4 ± 11.8%) in young (P < 0.05), abolishing the age group differences (P > 0.05). Cilostazol did not change ATP release in either age group (P > 0.05), and RBC cAMP and ATP release to pharmacological Gi protein activation was similar in both groups (P > 0.05). We conclude that decreased RBC deformability is a primary contributor to age‐related impairments in RBC ATP release, which may have implications for impaired vascular control with advancing age.
A facile surface enhanced Raman scattering substrate based on silver deposited sandpaper
Authors: Yuan Dongdong , Chen Shu , Wu Yanan , Wang Junqiao 
Published: July 2019

Flexible surface enhanced Raman scattering (SERS) substrate was prepared by modification of sandpaper with silver nanoparticles. Under 633 nm excitation wavelength, the SERS enhancement effect of sandpapers which were treated with silver nanoparticles were evaluated by collecting Raman signals of probed molecules. The results demonstrate that the SERS enhancement effect of white (12,000 meshes) is better than that of pink (8000 meshes) sandpaper under the same condition; when the concentration of probe molecules is [Formula: see text] mol/L, white sandpaper has the best SERS enhancement; the Raman scattering spectrum has better signal when the silver sol is 15 [Formula: see text].
Identification of Linear Time Invariant Systems Using FMCW Signals and Stretch Processing Receivers
Authors: Häfner Stephan , Thomä Reiner 
Published: July 2019

The paper deals with the identification of linear time invariant (LTI) systems by a special observer. An observer emitting an frequency modulated continuous wave (FMCW) signal and having a stretch processor as receiver will be considered for system identification. A thorough derivation of the gathered baseband signal for arbitrary LTI systems will be given. It is shown, that the received signal is approximately given by the transfer function of the LTI system over the frequency sweep of the FMCW signal. The proof relies on an infinite large time-bandwidth product of the transmit signal, such that errors remain in practical applications with a finite time-bandwidth product. Monte–Carlo simulations are conducted to verify the approximation and to quantify its accuracy and remaining errors. The findings are important for e.g. calibration or derivation of a device model in FMCW radar applications.
Evaluation of Simultaneous Speech Detection Based on MFCC-DTW with Two-Stage Normalization
Authors: Rusu Alexandru - George , Marinescu Radu-Sebastian , Burileanu Corneliu , Bica Dumitru 
Published: July 2019

In Air Traffic Control a serious safety risk is represented by undetected simultaneous transmissions from different airplanes. In this paper, we approach this issue through a speech analysis algorithm, which combines traditional Mel Frequency Cepstral Coefficients extraction, a new two-stage normalization and widely used Dynamic Time Warping. In this way, we were able to extend the simultaneous speech detection capability in Voice Communication Systems of Air Traffic Control. The results prove that this implementation is suitable for practical applications.
Association Between Long‐Term Exposure to Wind Turbine Noise and the Risk of Stroke: Data From the Danish Nurse Cohort
Authors: Bräuner Elvira V. , Jørgensen Jeanette T. , Duun‐Henriksen Anne Katrine , Backalarz Claus , Laursen Jens E. , Pedersen Torben H. , Simonsen Mette K. , Andersen Zorana J. 
Published: July 2019

Background

Epidemiological studies suggest that road traffic noise increases the risk of stroke. Similar effects may be expected from wind turbine noise (
WTN
) exposure, but epidemiological evidence is lacking. The present study investigated the association between long‐term exposure to
WTN
and the risk for stroke.

Methods and Results

First‐ever stroke in 28 731 female nurses in the Danish Nurse Cohort was identified in the Danish National Patient register until the end of 2013.
WTN
, traffic noise, and air pollution exposures were estimated for all historic and present residential addresses between 1982 and 2013. Time‐varying Cox proportional hazard regression was used to examine the associations between the 11‐, 5‐, and 1‐year rolling means of
WTN
levels and stroke incidence. Of 23 912 nurses free of stroke at the cohort baseline, 1097 nurses developed stroke by the end of follow‐up. At the cohort baseline, 10.3% of nurses were exposed to
WTN
(≥1 turbine within a 6000‐meter radius of the residence) and 13.3% in 2013. Mean baseline residential noise levels among exposed nurses were 26.3
dB
(A). No association between long‐term
WTN
exposure and stroke incidence was found. The adjusted hazard ratios and 95% CIs for the 11‐, 5‐, and 1‐year running mean residential
WTN
exposures preceding stroke diagnosis, comparing nurses with residential
WTN
levels above and below 20
dB
(A) were 1.09 (0.90–1.31), 1.08 (0.89–1.31) and 1.08 (0.89–1.32), respectively.

Conclusions

This comprehensive cohort study lends no support to an association between long‐term
WTN
exposure and stroke risk.
Impacts of the Religious Policies Enacted from 1965 to 1980 on Christianity in Indonesia
Authors: Sukamto Amos , Herlina Nina , Sofianto Kunto , Soleiman Yusak 
Published: July 2019

Abstract
Between 1965 and 1980, the Indonesian government issued three religious policies. These had both positive and negative impacts on Christianity in Indonesia. As a positive impact, the Indonesian Council of Churches (DGI) and the Supreme Council of Indonesian Bishops (MAWI) were motivated to work together in lobbying the government. The policies also boosted the growth of local leadership in Catholic churches. However, the policies also brought a negative impact in that it became difficult for churches to obtain an IMB (Building Permit). In mid-eighties, Christianity could still perform religious services in churches without any disturbances, but after the 1990s, churches with no Building Permit were banned by some radical Islamic organizations. Preaching the gospel was considered violation of the law and a Christian could be sent to prison for performing this activity.
What Is Gained and What Is Lost by the Faith-based Organization (FBO) Term?
Authors: Haugen Hans Morten 
Published: July 2019

Abstract
The growing interest in the role of faith-based organizations (FBOs) in promoting social development is welcome, but the article nevertheless questions the value of the broad term FBOs. The categorizations of FBOs do not bring adequate clarity. Four justifications for keeping the FBO term are analyzed: (i) highlighting the importance of religion and the size of FBOs; (ii) identifying characteristics of FBOs, specifically extensive networks and stronger local presence; (iii) surveillance of FBOs as potentially divisive actors; and (iv) necessary to map donations. Four justifications for scrapping the FBO term are also analyzed: (i) the term FBO might give connotations to religiously extremist movements – or to Western worldviews; (ii) the emphasis on the “devotedness” inherent in FBOs might directly and indirectly promote behavioral economics; (iii) both religion and FBOs might become “essentialized”; and (iv) research of FBOs is characterized by a lack of rigorous methodological, investigative approach.
The Spirit and the Many-sided Other: Amos Yong’s Pneumatological Re-imagining of Mission Theology
Authors: Anderson Christian J. 
Published: July 2019

Abstract
This article explores Amos Yong’s contributions to missiology through his concept of “pneumatological imagination” – that is, the hermeneutical embrace of Pentecost’s multivalent boundary-crossing potential. Two spheres of mission encounter that Yong has engaged with are examined: the spirit world, and the religions. In the Spirit’s encounter with spirit cosmologies, Yong looks for fruitful lines of continuity rather than radical severance, and develops a theology of “the powers” which connects the spirits to structural realities. In the Spirit’s encounter with the religions, Yong sets out avenues for discerning the Holy Spirit’s presence and activity in settings where Christ is not known or named. In this second, more controversial, area, Yong’s approach is critiqued for blurring the distinction between the Spirit’s sustaining and liberating activity. Concrete examples are suggested for how the Spirit might be seen as missionally active within non-Christian religions in ways that are more verifiably Christo-logical.
The Figure of the Taṇḍa in Old Javanese Literary and Epigraphical Records
Authors: Jákl Jiří 
Published: July 2019

Abstract
This article offers a detailed analysis of the category of men known as taṇḍa. Widely attested in literary records and known from Old Javanese inscriptions, the function and social status of taṇḍa has been a controversial issue. Two views pertaining to the identity of these men have been advanced so far. According to most scholars, taṇḍa were high-status officials, often interpreted as military ‘officers’. According to an alternative view, they were low-status military figures and their function was to oversee markets, or they were low-status figures associated with music and performances. This article argues that until at least 1200 CE taṇḍa were court-based, active combatants, who had troops of their own followers at their disposal and were responsible for the military expansion of Javanese states. By the Majapahit period they were integrated as regular troops into the progressively more hierarchical system of the professional standing army, which resulted in their reduced social status.
Found in Translation
Authors: Downes Meghan 
Published: July 2019

Abstract
Indonesian author Eka Kurniawan achieved huge critical success globally during 2015–2016 with his translated novels Beauty is a wound and Man tiger, which have been praised for their sweeping historical scope, ‘magical realist’ elements, and experimentation with voice and genre. First published in the Indonesian language more than a decade earlier as Cantik itu luka and Lelaki harimau, these novels initially faced a relatively lukewarm reception locally. Only once Eka Kurniawan’s work had been ‘found in translation’ was he taken more seriously in Indonesian media coverage. This article charts Eka Kurniawan’s rise to literary fame, paying particular attention to the shifting tone and content of reviews, marketing, cover art, and media representations, as the translated novels circulated globally. I use this case to examine two key issues: firstly, the ways in which certain genres such as horror and crime are ‘othered’ in the Indonesian literary landscape; and secondly, how processes of translation, distribution, and reception outside Indonesia can significantly impact local interpretations of an author and their work. In doing so, this article demonstrates that the politics of genre and the power relations of international publishing both contribute to complex patterns of inclusion and exclusion from ‘local’ and ‘global’ literary canons.
Mammary Dysbiosis and Nipple Blebs Treated With Intravenous Daptomycin and Dalbavancin
Authors: Mitchell Katrina B. , Eglash Anne , Bamberger Ethan T. 
Published: July 2019

Introduction Mammary dysbiosis, also known as subacute mastitis, may be associated with nipple blebs. These overlapping diagnoses represent a challenging clinical scenario during lactation. Little research has been published on etiology, management strategies, and outcomes of these concurrent diagnoses. Main issue We document the treatment and outcome of a patient who presented with left-breast dysbiosis and nipple blebs and whose milk culture grew multi-drug-resistant, methicillin-resistant Staphylococcus aureus. She was treated safely and effectively with intravenous daptomycin and dalbavancin. This has not been described previously in the lactation literature. Management The 35-year-old lactating gravida 3, para 3 patient presented at 6 months postpartum to a breast surgery clinic with a 1-week history of worsening deep left-breast pain, blebs, and recurrent plugging. She was afebrile and she had no erythema or induration on her breast exam. A culture of her milk grew multi-drug-resistant, methicillin-resistant Staphylococcus aureus, and she was referred to infectious disease for assistance with intravenous antibiotic therapy. She continued to feed expressed milk throughout treatment and demonstrated complete resolution of symptoms 8 weeks later. Conclusions We report that in patients with a multi-drug-resistant, methicillin-resistant Staphylococcus aureus–positive human milk culture and a clinical presentation of mammary dysbiosis and nipple blebs, intravenous daptomycin and dalbavancin may be an effective treatment.
Rapid Inactivation of Non-Endospore-Forming Bacterial Pathogens by Heat Stabilization is Compatible with Downstream Next-Generation Sequencing
Authors: Schroeder Max R. , Loparev Vladimir 
Published: July 2019

Introduction:Heat stabilization treatment preserves the in vivo state of biological samples by rapidly inactivating enzymes that cause degradation of proteins and nucleic acids. Historically, proteomics studies used this technique as an alternative to chemical fixation. More recently, microbiologists discovered that heat stabilization treatment rapidly inactivates pathogens present in tissue samples and preserves deoxyribonucleic acid (DNA) in the tissue. However, these recent studies did not investigate the inactivation of high-density bacterial suspensions and the quality of bacterial DNA.Methods and Results:High-density suspensions of Escherichia coli (>109cfu/mL) were completely inactivated by heat stabilization treatment using the Denator Stabilizor T1 instrument at 72°C and 95°C for 45 seconds. Using the heat stabilization instrument, a panel of 30 species, 20 Gram-negative and 10 non-endospore-forming Gram-positive species, were fully inactivated by treatment (95°C for 45 seconds). DNA was isolated from bacterial suspensions of Gram-negative bacteria, including E. albertii, E. coli, Shigella dysenteriae, and S. flexneri, following inactivation via heat stabilization treatment and without treatment. DNA isolated following heat stabilization treatment was fully compatible with all downstream molecular applications tested, including next-generation sequencing, pulsed-field gel electrophoresis, multiplex polymerase chain reaction (PCR), and real-time PCR.Conclusions and Discussion:Heat stabilization treatment of Gram-negative and non-endospore-forming Gram-positive pathogens completely inactivates high-density bacterial suspensions. This treatment is compatible with downstream DNA molecular assays, including next-generation sequencing, pulsed-field gel electrophoresis, and PCR. Inactivation by heat stabilization is a rapid process that may increase safety by decreasing risks for laboratory-associated infections and risks associated with transportation of infectious materials.
Change in incidence, characteristics and management of colorectal neuroendocrine tumours in the Netherlands in the last decade
Authors: Kooyker Arthur I , Verbeek Wieke HM , van den Berg José G , Tesselaar Margot ET , van Leerdam Monique E 
Published: July 2019

BackgroundNeuroendocrine tumours (NETs) are rare. However, a rising incidence has been reported over the past decades. For colorectal NETs, this is presumably caused by an increased awareness of colorectal diseases and colonoscopic procedures. This study aims to analyse the change in incidence of colorectal NETs, characteristics and management and evaluate the proportion of colorectal NETs detected in a national colorectal cancer (CRC) screening programme.MethodsHistopathological reports on colorectal well‐differentiated NETs detected between 2006 and 2016 were collected from the Dutch pathology database (PALGA) containing nationwide histo‐ and cytopathology reports of all pathology laboratories in the Netherlands.ResultsColorectal NETs were detected in 1055 individuals. Increasing incidence rates were observed from 0.36 per 100,000 inhabitants in 2006 to 0.75 per 100,000 inhabitants in 2011 (p value < 0.001), remaining stable afterward. Most NETs were grade I (73.5%) and detected in the rectum (76.4%). The majority (88.2%) were detected by colonoscopy, and the final intervention depended significantly on primary location of the tumour; 94.6% of rectal NETs were endoscopically removed, whereas 61.0% of colonic NETs were removed by surgery. There was an increase in local excision both of rectal and colonic NETs over the years instead of radical resection. Screening for CRC started in 2014 and contributed by detecting 32% of the diagnosed colorectal NETs within the invited age group, of which 94.6% were detected at an early stage.ConclusionThe incidence of reported colorectal NETs in the Netherlands doubled over the last decade. The Dutch CRC screening programme had a clear contribution to colorectal NETs incidence among its target population. A shift to more local management of detected lesions was observed over time.
Association Between Postoperative Dexmedetomidine Use and Arrhythmias in Infants After Cardiac Surgery
Authors: Ortmann Laura A. , Keshary Meera , Bisselou Karl Stessy , Kutty Shelby , Affolter Jeremy T. 
Published: July 2019

Background: Dexmedetomidine has been suggested as an arrhythmia prophylactic agent after surgery for congenital heart disease due to its heart rate lowering effect, though studies are conflicting. We sought to study the effect of dexmedetomidine in infants that are at highest risk for arrhythmias. Methods: Retrospective cohort study of infants less than six months of age undergoing cardiopulmonary bypass for congenital heart disease. The arrhythmia incidence in the first 48 hours after surgery in infants receiving dexmedetomidine for sedation was compared to those that did not receive dexmedetomidine. Results: A total of 309 patients were included, 206 patients who did not receive dexmedetomidine and 103 patients who did. The incidence of tachyarrhythmias was similar between the non-DEX group and the DEX group (19% vs 15%, P = .34). When adjusted for baseline differences, the non-DEX group did not have an increased risk of postoperative tachyarrhythmias (odds ratio [OR]: 1.4, 95% confidence interval [CI]: 0.5-3.8). The non-DEX group had an increased need for treatment for arrhythmias (18% vs 8%, P = .012). The three lesions with baseline higher risk for arrhythmias (tetralogy of Fallot, transposition of the great arteries, and complete atrioventricular canal) had an increased incidence of tachyarrhythmias in the non-DEX group (34% vs 6%, P = .027). This risk was not significant in multivariate analysis (OR: 2.5, 95% CI: 0.4-15.5). Conclusions: High-risk infants had decreased incidence of tachyarrhythmias when receiving dexmedetomidine, though this was not significant after accounting for baseline differences between groups.
Do Neural Information Extraction Algorithms Generalize Across Institutions?
Authors: Santus Enrico , Li Clara , Yala Adam , Peck Donald , Soomro Rufina , Faridi Naveen , Mamshad Isra , Tang Rong , Lanahan Conor R. , Barzilay Regina , Hughes Kevin 
Published: July 2019

PURPOSE Natural language processing (NLP) techniques have been adopted to reduce the curation costs of electronic health records. However, studies have questioned whether such techniques can be applied to data from previously unseen institutions. We investigated the performance of a common neural NLP algorithm on data from both known and heldout (ie, institutions whose data were withheld from the training set and only used for testing) hospitals. We also explored how diversity in the training data affects the system’s generalization ability. METHODS We collected 24,881 breast pathology reports from seven hospitals and manually annotated them with nine key attributes that describe types of atypia and cancer. We trained a convolutional neural network (CNN) on annotations from either only one (CNN1), only two (CNN2), or only four (CNN4) hospitals. The trained systems were tested on data from five organizations, including both known and heldout ones. For every setting, we provide the accuracy scores as well as the learning curves that show how much data are necessary to achieve good performance and generalizability. RESULTS The system achieved a cross-institutional accuracy of 93.87% when trained on reports from only one hospital (CNN1). Performance improved to 95.7% and 96%, respectively, when the system was trained on reports from two (CNN2) and four (CNN4) hospitals. The introduction of diversity during training did not lead to improvements on the known institutions, but it boosted performance on the heldout institutions. When tested on reports from heldout hospitals, CNN4 outperformed CNN1 and CNN2 by 2.13% and 0.3%, respectively. CONCLUSION Real-world scenarios require that neural NLP approaches scale to data from previously unseen institutions. We show that a common neural NLP algorithm for information extraction can achieve this goal, especially when diverse data are used during training.