bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing national prevention and treatment services for sex workers in Zimbabwe: a process evaluation of the SAPPH-IRe trial
Authors: Busza Joanna , Chiyaka Tarisai , Musemburi Sithembile , Fearon Elizabeth , Davey Calum , Chabata Sungai , Mushati Phillis , Dirawo Jeffrey , Napierala Sue , Phillips Andrew N , Cowan Frances M , Hargreaves James R 
Published: May 2019

Abstract
Targeted HIV interventions for female sex workers (FSW) combine biomedical technologies, behavioural change and community mobilization with the aim of empowering FSW and improving prevention and treatment. Understanding how to deliver combined interventions most effectively in sub-Saharan Africa is critical to the HIV response. The Sisters’ Antiretroviral Programme for Prevention of HIV: an Integrated Response (SAPPH-Ire) randomized controlled trial in Zimbabwe tested an intervention to improve FSW engagement with HIV services. After 2 years, results of the trial showed no significant difference between study arms in proportion of FSW with HIV viral load ≥1000 copies/ml as steep declines occurred in both. We present the results of a process evaluation aiming to track the intervention’s implementation, assess its feasibility and accessibility, and situate trial results within the national HIV policy context. We conducted a mixed methods study using data from routine programme statistics, qualitative interviews with participants and respondent driven surveys. The intervention proved feasible to deliver and was acceptable to FSW and providers. Intervention clinics saw more new FSW (4082 vs 2754), performed over twice as many HIV tests (2606 vs 1151) and nearly double the number of women were diagnosed with HIV (1042 vs 546). Community mobilization meetings in intervention sites also attracted higher numbers. We identified some gaps in programme fidelity: offering pre-exposure prophylaxis took time to engage FSW, viral load monitoring was not performed, and ratio of peer educators to FSW was lower than intended. During the trial, reaching FSW with HIV testing and treatment became a national priority, leading to increasing attendance at both intervention and control clinics. Throughout Zimbabwe, antiretroviral therapy coverage improved and HIV-stigma declined. Zimbabwe’s changing HIV policy context appeared to contribute to positive improvements across the HIV care continuum for all FSW over the course of the trial. More intense community-based interventions for FSW may be needed to make further gains.
Assimilating electronic tagging, oceanographic modelling, and fisheries data to estimate movements and connectivity of swordfish in the North Atlantic
Authors: Braun Camrin D , Gaube Peter , Afonso Pedro , Fontes Jorge , Skomal Gregory B , Thorrold Simon R 
Published: May 2019

Abstract
Broadbill swordfish (Xiphias gladius) is a key species in commercial fisheries, but management efforts continue to be hindered by data gaps in their basic biology, including ongoing debate over stock boundaries and movement between management zones. We deployed 20 pop-up satellite archival transmitting (PSAT) tags on juvenile swordfish in the Azores and adults in the northwest Atlantic (NWA). We applied a recently developed geolocation approach that synthesizes tag data with a global observation-assimilating ocean model to improve geolocation accuracy. Resulting tracks from 16 individuals averaged 3751 km (range 345–7247 km) over 93 days (range 17–181 days). Juveniles tagged in the Azores made regional movements while adults tagged in the NWA moved between summer foraging grounds near the Grand Banks to winter habitats near the Antillean Arc. All individuals spent considerable time in the mesopelagic zone during the day, and this behaviour increased with fish size. We integrate results from our PSAT-based movements with conventional tag and catch-per-unit effort data, which indicates complex stock structure within the North Atlantic that largely supports current stock boundaries. Our work demonstrates the utility in synthesizing fishery-independent electronic tag data and fisheries datasets to improve our understanding of large pelagic fish ecology.
Nutrient digestibility of multi-enzyme supplemented low-energy and AA diets for grower pigs1
Authors: Lee Jung Wook , Patterson Robert , Rogiewicz Anna , Woyengo Tofuko A 
Published: May 2019

Abstract
A study was conducted to determine effects of supplementing multi-enzyme on apparent ileal digestibility (AID) of energy and AA; and apparent total tract digestibility (ATTD) of energy for pigs fed low-energy and AA diets. Eight ileal-cannulated barrows (initial BW: 38.7 ± 2.75 kg) were fed four diets in a replicated 4 × 4 Latin square design to give 8 replicates per diet. Diets were positive control (PC) diet, negative control (NC) diet without or with multi-enzyme at 0.5 or 1.0 g/kg. The PC diet was formulated to meet or exceed NRC (2012) nutrient recommendations for grower pigs (25 to 50 kg), except for Ca and digestible P, which were lower than NRC (2012) recommendations by 0.13 and 0.17 percentage points, respectively, due to phytase supplementation at 1,000 FTU/kg. The NC diet was formulated to be lower in NE by 75 kcal/kg and standardized ileal digestible AA content by a mean of 3%. These reductions were achieved by partial replacement of corn and soybean meal (SBM) and complete replacement of soybean oil and monocalcium phosphate in PC diet with 25% corn distillers dried grains with solubles (DDGS) and 3.6% soybean hulls. Multi-enzyme at 1.0 g/kg supplied 1,900 U of xylanase, 300 U of β-glucanase, 1,300 U of cellulase, 11,500 U of amylase, 120 U of mannanase, 850 U of pectinase, 6,000 U of protease, and 700 U of invertase per kilogram of diet. The AID of GE, N, most AA, most component sugars of nonstarch polysaccharides (NSP) and P; ATTD of GE for PC diet was greater (P < 0.05) than those for NC diets. An increase in dietary level of multi-enzyme from 0 to 1.0 g/kg resulted in a linear increase (P < 0.05) in AID of Ile by 4.3%, and tended to linearly increase (P < 0.10) AID of Leu, Met, Phe, and Val by a mean of 3.4%. Increasing dietary multi-enzyme from 0 to 1.0 g/kg linearly increased (P < 0.05) AID of total NSP and P by 53.7% and 19.2%, respectively; ATTD of GE by 8.4% and DE and NE values by 8.8% and 8.2%, respectively; tended to linearly increase (P < 0.10) AID of GE by 8.1%. The NE values for NC diet with multi-enzyme at 1.0 g/kg tended to be greater (P < 0.10) than that for PC diet (2,337 vs. 2,222 kcal/kg of DM). In conclusion, multi-enzyme supplementation improved energy and nutrient digestibilities of a corn–SBM–corn DDGS-based diet, implying that the multi-enzyme fed in the current study can be used to enhance energy and nutrient utilization of low-energy AA diets for grower pigs.
Age at arrival, parents and neighborhoods: understanding the educational attainment of immigrants’ children
Authors: Ansala Laura , Hämäläinen Ulla , Sarvimäki Matti 
Published: May 2019

AbstractThis article documents how children of immigrants cope in early adulthood in Finland. We first show that, on average, they have dramatically lower educational attainment than children of natives do. This difference can be attributed to age at arrival, parental income and neighborhood quality. In fact, Finnish-born children of immigrants obtain more education than children of natives growing up in the same zip codes and in families with similar parental income and family structure. Sibling comparisons suggest that age at arrival has a causal impact on educational attainment. The results are very similar for the likelihood of being idle and having been convicted of a crime, but are starkly different for the likelihood of having been reimbursed for psychotropic medication.
Global production networks: mapping recent conceptual developments
Authors: Coe Neil M , Yeung Henry Wai-chung 
Published: May 2019

Abstract
In this framing paper for the special issue, we map significant research on global production networks during the past decade in economic geography and adjacent fields. In line with the core aim of the special issue to push for new conceptual advances, the paper focuses on the central elements of GPN theory to showcase recent rethinking related to the delimiting of global production networks, underlying political-economic drivers, actor-specific strategies and regional/national development outcomes. We suggest that the analytical purchase of this recent work is greater in research that has continued to keep a tight focus on the causal links between the organizational configurations of global production networks and uneven development. Concomitantly, considerable effort in the literature has gone into expanding the remit of GPN research in different directions, and we thus engage with five domains or ‘constituent outsides’ that relate to the state, finance, labour, environment and development. We believe such cross-domain fertilisation can help realize GPN 2.0’s potential for explaining uneven development in an interconnected world economy.
Who is in charge? Jurisdictional contests and organizational outcomes
Authors: Feyereisen Scott , Goodrick Elizabeth 
Published: May 2019

AbstractWe explored how professional jurisdiction contests influence organizational outcomes by examining how Certified Registered Nurse Anesthetist (CRNA) schools in the USA were impacted by a policy pursuing educational upskilling. While others have focused on boundary work at the field and work levels, we argue that contests between professions also influence important organizational outcomes. We detail how the profession’s accreditation decision requiring schools to provide Master’s degrees within a 17 year window took place in the context of physicians historically battling CRNAs. We provide an analytic narrative illustrating the history of this jurisdictional dispute, and empirically examine how CRNA schools with cultures differentially supportive of physicians’ field-level dominance responded to the requirement of educational upskilling. Our analysis indicates that the timing of a school adopting a graduate program was influenced by whether the organizational culture, represented by organizational ownership, supported physician dominance. We also highlight the importance of access to resources as another conduit for boundary work impacting organizational outcomes.
Long-term soft and hard X-ray investigation of the colliding wind WN+O binary WR 25
Authors: Arora Bharti , Pandey J C , De Becker M 
Published: May 2019

ABSTRACT
We investigated the long-term behaviour in X-rays of the colliding wind binary WR 25, using archival data obtained with Suzaku, Swift, XMM–Newton, and NuSTAR spanning over ∼16 yr. Our analysis reveals phase-locked variations repeating consistently over many consecutive orbits, in agreement with an X-ray emission fully explained by thermal emission from the colliding winds in the 208-d orbit. We report on a significant deviation of the X-ray flux with respect to the 1/D trend (expected for adiabatic shocked winds) close to periastron passage. The absence of a drop in post-shock plasma temperature close to periastron suggests this break in trend cannot be explained in terms of reduced pre-shock velocities in this part of the orbit. Finally, NuSTAR data reveal a lack of hard X-ray emission (above 10.0 keV) above the background level. Upper limits on a putative non-thermal emission strongly suggest that the sensitivity of present hard X-ray observatories is not sufficient to detect non-thermal emission from massive binaries above 10 keV, unless the wind kinetic power is large enough to significantly feed particle acceleration in the wind–wind interaction.
Whole Sella vs Targeted Stereotactic Radiosurgery for Acromegaly: A Multicenter Matched Cohort Study
Authors: Taylor Davis G , Janssen Andrew , Ding Dale , Xu Zhiyuan , Mehta Gautam U , Liscak Roman , Kano Hideyuki , Kosak Mikulas , Martinez-Moreno Nuria , Hobbs Landon , Chen Ching-Jen , Grills Inga S , Mathieu David , Lunsford L Dade , Vance Mary Lee , Sheehan Jason P 
Published: May 2019

Abstract

BACKGROUND
Targeted stereotactic radiosurgery (SRS) with sparing of the residual pituitary is the traditional radiosurgical method for pituitary adenomas. Whole-sella SRS is an alternative choice for radiologically indeterminate or large adenomas, the safety and efficacy of which has yet to be determined.

OBJECTIVE
To determine if whole-sella SRS in acromegaly would have comparable radiographic and biochemical control to targeted SRS. We performed a multicenter, retrospective matched cohort study to compare outcomes between groups.

METHODS
We conducted a retrospective review of acromegalic patients who underwent SRS from 1990 to 2016 at 10 centers participating in the International Radiosurgery Research Foundation. Whole-sella and targeted SRS patients were then matched in a 1:1 ratio.

RESULTS
A total of 128 patients were eligible for inclusion. Whole-sella patients had a higher pre-SRS random serum growth hormone, larger treatment volume, and higher maximum point dose to the optic apparatus. The rates of initial/durable endocrine remission, new loss of pituitary function, and new cranial neuropathy were similar between groups. Mortality and new visual deficit were higher in the whole-sella cohort, though not statistically significant.

CONCLUSION
There was no difference in biochemical remission or recurrence between treatment groups. Although not statistically significant, the higher rates of tumor regression and lower rates of mortality and new visual deficit may suggest consideration of targeted SRS over whole-sella SRS in acromegaly treatment. Further research is needed to determine the association between visual deficits and mortality with whole-sella SRS.
Kinematics Following 3-Screw Integrated Interbody Spacers in the Lumbar Spine
Authors: Heary Robert F , Agarwal Nitin , Parvathreddy Naresh K , Hansberry David R , Ferrara Lisa A 
Published: May 2019

Abstract

BACKGROUND
“Stand-alone” fusion implants attempt to alleviate the need for supplemental posterior instrumentation.

OBJECTIVE
A biomechanical study was conducted to assess the stability of an integrated 3- screw interbody cage with, and without, supplemental posterior fixation.

METHODS
Nondestructive biomechanical testing was performed on 19 healthy cadaver spine segments. Specimens were tested in 6 degrees of motion and a maximum pure bending moment of 10 Nm was applied. Specimens were evaluated in the following sequence: Intact, cage, cage ± facet bolts, and cage ± pedicle screws. Nonconstrained motion was measured at both the index and adjacent levels.

RESULTS
The index levels were L2-L3 and L5-S1. The cage alone provided a significant decrease in motion at the L2-L3 level but not at L5-S1. At L2-L3, cage + pedicle screws decreased motion more effectively than cage + facet bolts, however, both the supplemented constructs outperformed intact (P < .05). At L5-S1, both posterior fixation systems appeared to have smaller degree of displacement compared to intact; however, no significant differences were observed at L5-S1 among the various constructs. Furthermore, the adjacent segments for each level (L1-L2 and L4-L5) had no significantly increased motion, compared to intact, for all 6 degrees of motion tested.

CONCLUSION
The stand-alone cage was more effective at L2-L3, than at L5-S1, in limiting motion. At L5-S1, supplemental fixation may need to be considered. No abnormal motion was identified at the adjacent, normal segments, for the stand-alone, or the circumferential constructs at either level tested.
The Control of Zealactone Biosynthesis and Exudation is Involved in the Response to Nitrogen in Maize Root
Authors: Ravazzolo Laura , Trevisan Sara , Manoli Alessandro , Boutet-Mercey St�phanie , Perreau Fran�ois , Quaggiotti Silvia 
Published: May 2019

AbstractNitrate acts as a signal in regulating plant development in response to environment. In particular nitric oxide, auxin and strigolactones (SLs) were supposed to cooperate to regulate the maize root response to this anion. In this study, a combined approach based on liquid chromatography-quadrupole/time-of-flight tandem mass spectrometry and on physiological and molecular analyses was adopted to specify the involvement of SLs in the maize response to N. Our results showed that N deficiency strongly induces SL exudation, likely through stimulating their biosynthesis. Nitrate provision early counteracts and also ammonium lowers SL exudation, but less markedly. Exudates obtained from N-starved and ammonium-provided seedlings stimulated Phelipanche germination, whereas when seeds were treated with exudates harvested from nitrate-provided plants no germination was observed. Furthermore, our findings support the idea that the inhibition of SL production observed in response to nitrate and ammonium would contribute to the regulation of lateral root development. Moreover, the transcriptional regulation of a gene encoding a putative maize WBC transporter, in response to various nitrogen supplies, together with its mRNA tissue localization, supported its role in SL allocation. Our results highlight the dual role of SLs as molecules able to signal outwards a nutritional need and as endogenous regulators of root architecture adjustments to N, thus synchronizing plant growth with nitrogen acquisition.
Orbital angular momentum of Liénard–Wiechert fields
Authors: Kawaguchi H , Katoh M 
Published: May 2019

Abstract
We derive a general expression for the electromagnetic field radiated by a relativistic charged particle with arbitrary periodic orbit, in the form of multi-pole expansion of the Liénard–Wiechert potential, which explicitly includes the charged particle motion. Using this expression, we discuss the orbital angular momentum radiated from a relativistic charged particle. It has recently been indicated that the radiation emitted by circularly orbiting charged particles carries well-defined orbital angular momentum. We show that, even for the general cases of arbitrary periodic orbits, the radiation field possesses well-defined orbital angular momentum.
Distinctive association of peripheral immune cell phenotypes with capillaroscopic microvascular patterns in systemic sclerosis
Authors: Kubo Satoshi , Nakayamada Shingo , Miyazaki Yusuke , Yoshikawa Maiko , Yoshinari Hiroko , Satoh Yurie , Todoroki Yasuyuki , Nakano Kazuhisa , Satoh Minoru , Smith Vanessa , Cutolo Maurizio , Tanaka Yoshiya 
Published: May 2019

AbstractObjectiveThe pathological changes in SSc include immune system dysregulation and microvascular damage. However, the association of immune cell phenotype heterogeneity and microvascular abnormalities is unclear. The aim of this study is to elucidate this association in SSc.MethodsPeripheral blood mononuclear cells obtained from 150 SSc patients were used for comprehensive flow cytometric analysis based on the Human Immunology Project. Hierarchical cluster analysis was used to classify SSc patients into subgroups and their association with microvascular abnormalities, as assessed by nailfold videocapillaroscopy (i.e. ‘early’, ‘active’ and ‘late’ patterns), was analysed.ResultsThe proportions of activated CD4+ T cells, T cells re-expressing CD45RA, activated Th1 and Th17 cells and IgD−CD27− B cells were higher in SSc patients than in healthy individuals. Hierarchical cluster analysis stratified SSc patients into three groups: patients with few immune abnormalities (fewer abnormalities group), patients with high proportions of activated T and Treg cells (Treg-dominant group) and patients with high proportions of Tfh and plasmablasts (Tfh-dominant group). Age and disease duration were comparable among the groups. On the other hand, microvascular abnormalities, especially the ‘late’ nailfold videocapillaroscopy pattern, correlated with internal organ involvement. Among the groups stratified according to immune cell phenotype, the progression to the ‘late’ nailfold videocapillaroscopy pattern was more frequent in the Tfh-dominant group.ConclusionOur study confirmed the presence of immunophenotypic abnormalities in SSc. Immunological abnormalities were not uniform but rather limited to subpopulations, particularly the Tfh-dominant group, where they were highly associated with microvascular abnormalities and organ involvement.
Technology-assisted cognitive-behavioral therapy intervention for end-stage renal disease
Authors: Jakubowski Karen P , Jhamb Manisha , Yabes Jonathan , Gujral Swathi , Oberlin Lauren E , Bender Filitsa H , Steel Jennifer L 
Published: May 2019

Abstract
Technology-assisted cognitive-behavioral therapy (CBT) interventions have been conducted for symptoms including depression, pain, and fatigue in patients with chronic illnesses but not in end-stage renal disease (ESRD). The purpose of this study was to pilot the feasibility and acceptability of a technology-assisted CBT intervention in ESRD patients on hemodialysis (HD), share design and implementation lessons learned, and provide preliminary results on changes in select patient-reported symptoms. This was a single-center pilot feasibility study of adult ESRD patients on HD. Study eligibility required clinically elevated levels of at least one symptom (depression, pain, or fatigue). Patients met weekly with a CBT therapist for eight sessions, each 45–60 min, during HD sessions via a video-conferencing platform. Symptom questionnaires were completed at baseline and 3 months follow-up. Of 10 patients screened, 100% screened positive for at least one symptom, 100% of eligible patients consented, and eight (of 10) completed the intervention (mean age 59 years, 50% male, 50% African American). Patient adherence and satisfaction was high, and seven of the eight patients completed all eight prescribed sessions. Minimal interference with HD was reported. Preliminary results indicate no statistically significant changes in depression, fatigue, or pain at follow-up. However, there was small improvement in SF-36 Physical Component score [t(7) = −2.60, p = .035], and four of the six patients (67%) with clinically elevated pain at baseline reported improvement at follow-up. A technology-assisted CBT intervention for ESRD patients was feasible, well-accepted, and required minimal additional resources in the HD setting. Larger, adequately powered clinical trials are needed to evaluate the effect on ESRD patient-reported outcomes.
Distribution of Psychotropic Drugs Into Lipoproteins
Authors: Serkland Trond T. , Schjøtt Jan , Berg Jon A. , Herfindal Lars , Riedel Bettina , Skrede Silje 
Published: May 2019

Aim:
The aim of this pilot study was to investigate whether psychotropic drugs frequently analyzed in a routine therapeutic drug monitoring laboratory bind to low-density lipoproteins/very-low-density lipoproteins (LDL/VLDL) in human serum.

Methods:
Drug concentrations in 20 serum sample pools containing one psychotropic drug each, and in the LDL/VLDL fractions extracted from the same samples, were measured by triple quadrupole liquid chromatography tandem mass spectrometry. The membrane permeability of the drugs was measured using a Parallel Artificial Membrane Permeability Assay.

Results:
Of the 20 antidepressants, antipsychotics, and antiepileptics examined, 7 drugs were detected in both the pooled serum samples and in the LDL/VLDL fraction. Binding of drugs to LDL/VLDL significantly correlated with high octanol: water partition coefficient (logP), high degree of protein binding, and a low polar surface area. The drugs found in LDL/VLDL, with the exception of aripiprazole, were also characterized by high or intermediate membrane permeability.

Conclusions:
The present results indicate that psychotropic drugs with certain characteristics bind to LDL/VLDL in blood. This further implies that lipoproteins could play an important role in drug transport.