bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family-Driven Goals to Improve Care for Children With Autism Spectrum Disorder
Authors: Bellesheim Katherine R. , Cole Lynn , Coury Daniel L. , Yin Larry , Levy Susan E. , Guinnee Meghan A. , Klatka Kirsten , Malow Beth A. , Katz Terry , Taylor Jane , Sohl Kristin 
Published: August 2018

OBJECTIVES:
Constipation and insomnia are not consistently identified and treated in children with autism spectrum disorder (ASD) despite their high prevalence and deleterious impact in this population. To standardize care, a constipation practice pathway and an insomnia practice pathway were previously developed by Autism Treatment Network clinicians. Our objective was to implement and refine these practice pathways in clinical settings.

METHODS:
Eleven Autism Treatment Network sites participated in a Learning Collaborative (ie, multidisciplinary quality improvement team) and chose to implement either the constipation or insomnia practice pathway in the clinical setting. Families set intervention goals (eg, increase stool frequency, decrease nighttime awakenings) before treatment. Each site began implementation with 1 patient and then increased implementation by factors of 5. Before each increase, the Learning Collaborative evaluated progress and refined the practice pathways. Process improvement was measured primarily by duration until goal attainment and by percentage of families who meet their goals.

RESULTS:
Across sites, 82 children with ASD and constipation and 101 children with ASD and insomnia were managed. Difficulties with intervention adherence and communication between providers and families were reported and were subsequently improved with parallel refinements to both practice pathways. The most notable modification was incorporating a goal-setting session in which families generated their own intervention goals (ie, family-driven goals). In this quality improvement initiative, 75% of families met at least 1 constipation or insomnia goal, with the median time to improvement being 6 weeks.

CONCLUSIONS:
By integrating a family-centered approach into the standardization of care, constipation and insomnia practice pathways may improve engagement, adherence, and management of medical conditions in children with ASD.
THEORETICAL ANALYSIS OF PICTURE FUZZY CLUSTERING: CONVERGENCE AND PROPERTY
Authors: Phuong Pham Thi Minh , Thong Pham Huy , Son Le Hoang 
Published: August 2018

Recently, picture fuzzy clustering (FC-PFS) has been introduced as a new computational intelligence tool for various problems in knowledge discovery and pattern recognition. However, an important question that was lacked in the related researches is examination of mathematical properties behind the picture fuzzy clustering algorithm such as the convergence, the boundary or the convergence rate, etc. In this paper, we will prove that FC-PFS converges to at least one local minimum. The similarities and differences between this algorithm and other clustering methods are compared. Analysis on the loss function is also considered.
Comprehensive Genomic Profiling of Hodgkin Lymphoma Reveals Recurrently Mutated Genes and Increased Mutation Burden
Authors: Liang Winnie S. , Vergilio Jo-Anne , Salhia Bodour , Huang Helen J. , Oki Yasuhiro , Garrido-Laguna Ignacio , Park Haeseong , Westin Jason R. , Meric-Bernstam Funda , Fabrizio David , Miller Vincent A. , Stephens Philip J. , Fanale Michelle A. , Ross Jeffrey S. , Janku Filip 
Published: August 2018

Abstract

Background
The genomic landscape of Hodgkin lymphoma (HL) has been difficult to characterize due to the paucity of neoplastic cells and an abundant microenvironment. Such characterization is needed in order to improve treatment strategies.

Materials and Methods
We performed comprehensive genomic profiling (CGP) using targeted next-generation sequencing on archival formalin-fixed paraffin embedded tumor samples from 63 patients to analyze the landscape of HL.

Results
CGP was successful for 49/63 archival specimens (78%), and revealed aberrations impacting genes including B2M, TP53, and XPO1 (E571). Of the 34 patients for whom total mutation burden (TMB; mutations/megabase [Mb]) was assessed, 5 (15%) had high TMB (≥20 mutations/Mb), 18 (53%) had intermediate TMB (6–19 mutations/Mb), and 11 (32%) had low TMB (≤5 mutations/Mb). We next tested 13 patients' plasma cell-free DNA with droplet digital polymerase chain reaction for the presence of XPO1 E571 mutation, which was confirmed in the plasma of 31% of patients. In three patients with serially collected plasma samples, XPO1 E571K allelic frequency changes corresponded with changes in tumor size on conventional radiographic imaging.

Conclusion
The study demonstrates that comprehensive genomic profiling of archival Hodgkin lymphoma tumor samples is feasible and leads to the identification of genes that are recurrently mutated and that Hodgkin lymphoma has increased mutation burden in the majority of samples analyzed. Furthermore, tracking of XPO1 E571 mutant allele frequency in a subset of patients may also represent a potential disease-monitoring strategy and warrants further investigation.

Implications for Practice
This study provides the first evidence that comprehensive genomic profiling can be performed to map the genomic landscape of Hodgkin lymphoma and that a subpopulation of patients has mutations in TP53, B2M, XPO1, and other genes. It was found that 15% of patients have high mutation burden, which, in cancers such as melanoma, may indicate sensitivity to immune checkpoint inhibitors, and may thus be explored for Hodgkin lymphoma. Lastly, this work demonstrates that changes in the mutant allele frequency of XPO1 in serially collected plasma cell-free DNA samples correspond with treatment outcomes measured with conventional radiographic imaging.
Atividade metalinguística em discussão: a refacção textual escrita de sujeitos afásicos
Authors: Macedo Heloísa Oliveira 
Published: August 2018

Although there have been several studies about the processses of rewriting texts there is none related to aphasia. Even thou rewriting is considered as an alternative to promote reflection, to searching for new ways and, therefore, as a new possibility of sigfiynig in a text, in language, it was never studied with brain damaged subjects. When the subjects recognizes the need to rewrite his text in order to make themselves understood in a more accurate way by his partners, they change their strategies, adjusts their language and positions themselves as a social subjects. The theory on which this work is based is the Neurolinguistics developed by Coudry (1986) and Morato (1995), discoursively oriented, which assumes the close relation between language and speech, language and cognition and between the subject and the social practices. Three aphasic subjects were followed while the process of writing texts about their history on aphasia, mainly about the consequences that the condition of being aphasics brought to their lives. The process of writing was carried together with the investigator, when they talked about their doubts and about the hyphotesis they made about the process of writing. The analysis shows that the cognitive aspects related to the knowledge of the roles and structures of a written text are preserved. In fact, they were able to recognize when something is not properly organized. In general, the research shows that the work with rewriting allows the subject to recover and/or improve their competence in reading and writing.
Alguns comentários sobre as modalidades de uso da língua-escrita, fala e escrita em tempo real
Authors: Madeira Fábio 
Published: August 2018

This paper discusses the language modalities. I will first discuss spoken language – its characteristics and its uses. Next I will comment on written language and in the following section I will discuss the written language produced for synchronous communication through the internet. Besides having presented a new means of communication, the written language produced in real time has presented a new language modality that unites characteristics of both spoken and written language. I will argue that a dichotomy between the two language modalities does not justify and that the differences between spoken and written language are related to the function for which a text is produced.
Pour une adaptation du modèle européen d’enseignement des langues étrangères en contextes latino–américains
Authors: Chareille Samantha 
Published: August 2018

La mayoría de los estudios franceses que se consagran a la investigación sobre autonomía en el ámbito de las lenguas extranjeras se refiere a los países europeos pero más escasos son los que hacen referencia a América latina. Porque precisamente tuvimos que llevar a cabo investigaciones similares sobre, entre otros, la planificación lingüística del Mercado común del Cono sur y de Chile (2001), el estatuto del francés en Uruguay (1997 y 2003) y en Colombia (2002), estuvimos especialmente interesadas por el tema de la enseñanza de las lenguas en América latina y por los sistemas educativos formales de la zona. Nuestro objetivo será poner de manifiesto que algunos principios de las políticas lingüísticas educativas europeas podrían ser utilizables en los contextos latinoamericanos. Nos concentraremos en particular en el Marco europeo común de referencia para las lenguas, su Portafolio y en el modelo europeo de centro de recursos de lenguas. También se hará referencia a tales conceptos como las habilidades lingüísticas parciales y la autonomía. El marco limitado de este artículo, que no nos permite ser tan exhaustivas como lo desearíamos, comenzaremos por un rápido panorama de la situación educativa latinoamericana con un énfasis en la enseñanza de las lenguas. Luego pasaremos a la exposición de las políticas lingüísticas educativas europeas que nos interesan en el marco de este estudio para concluir sobre los centros de recursos en cuestión.
الدراسة التقابلية في بنية الجمع بين اللغة العربية واللغة الإندونيسية
Authors: Fajriana Fitriah 
Published: August 2018

التجريد
هذا البحث لوصف بنية الجمع بين اللغة العربية واللغة. والطريقة المستخدمة في هذا البحث هي الطريقة التحليلية الوصفية للدراسة التقابلية في بنية الجمع بين اللغة العربية واللغة الإندونيسي البحث في دراسة التحليل التقابلي . ومن هنا نلاحظ أيضا أن ليس من الغريب أن نقول أننا لن ننفي أن هناك الاختلافات بين هاتين اللغتين التي تحمل معها الصعوبات في تعلم وتعليم اللغة العربية في إندونيسيا. وتتمكن هذه الصعوبات من ظهور الخيرة والغلط والزلل أثناء استخدام اللغة العربية. ومن المؤسف الشديد أن تعلم اللغة العربية في إندونيسيا يتركز على دراسة القواعد مثل النحو والصرف، ولم يكن مرتكزاً على المهارات الأخرى. وفوق هذا أن فرصة تطبيقها تحدثا وكتابيا واستماعيا لم تكن متوفرة.
Evaluasi program pengendalian leptospirosis di kabupaten Gunungkidul 2017
Authors: Arsyad Agus Salim 
Published: August 2018

Tujuan: Leptospirosis adalah suatu infeksi zoonosis global yang disebarkan melalui air yang disebabkan oleh bakteri dari genus Leptospira. Data surveilans Dinas Kesehatan Kabupaten Gunungkidul menunjukkan peningkatan kasus leptospirosis pada tahun 2017 dibandingkan dengan tahun 2016. Pada Januari-April 2017 terdapat 54 kasus leptospirosis yang tersebar di delapan kecamatan. Dari 56 kasus terdapat 16 kasus yang meninggal dan Case Fatality Rate (CFR) 26,78 %. Evaluasi yang dilakukan bertujuan untuk mengetahui gambaran dan permasalahan pelaksanaan program pengendalian leptospirosis di Kabupaten Gunungkidul. Metode: Ini adalah penelitian deskriptif yang berfokus pada input, process dan output dari program pengendalian leptospirosis. Data dikumpulkan dengan mewawancarai petugas leptospirosis di Dinas Kesehatan Kabupaten Gunungkidul dan sebelas puskesmas yang memiliki kasus leptospirosis pada tahun 2017 dengan menggunakan kuesioner dan lembar observasi. Peneltian dilakukan selama bulan Mei sampai September 2017. Hasil: Program pengendalian leptospirosis merupakan bagian dari program zoonosis yang baru dibentuk pada bulan Maret 2017. Hasil evaluasi pada aspek input, semua petugas zoonosis sudah mendapatkan pelatihan walaupun didapatkan setelah puncak kasus pada bulan Januari-April tahun 2017; Dinas Kesehatan Kabupaten Gunungkidul sudah mengusahakan dengan optimal ketersediaan Rapid Diagnostic Test (RDT) untuk puskesmas yang ada kasus leptospirosis. Pada aspek process, belum adanya perencanaan untuk kegiatan pengendalian leptospirosis karena merupakan program baru, kegiatan penyuluhan dilakukan pada saat Penyelidikan Epidemiologi (PE). Pada aspek output, semua kasus sudah dilakukan PE dan tercatat, hanya ada satu puskesmas yang tidak melakukan PE terhadap semua kasus leptospirosis, hal ini terjadi karena adanya tugas ganda dan kurangnya koordinasi petugas zoonosis dengan petugas surveilans di puskesmas. Simpulan: Program zoonosis terutama pengendalian leptospirosis telah dilaksanakan di Kabupaten Gunungkidul walaupun ada beberapa kelemahan pada input, prosess, dan output. Berdasarkan evaluasi, perlu dibuat perencanaan yang tepat untuk program pengendalian leptospirosis pada tahun 2018, keseragaman dalam pelaporan, dan peraturan yang baku dalam program pengendalian leptospirosis yang melibatkan program lintas sektoral.
Kenapa putus berobat? Bagaimana efektifitas monitoring dalam upaya meningkatkan kepatuhan pengobatan pasien TB : studi kasus di Provinsi Jawa Tengah
Authors: Anggraini Riana Dian , Orianti Wa Ode Siti , Rahayu Eka Putri 
Published: August 2018

Succes Rate Provinsi Jawa Tengah empat tahun terakhir ini mengalami trend penurunan dari tahun 2013 sebesar 89,04% dan ditahun 2016 menjadi 68,69%. Intervensi perlu dilakukan untuk mencegah meningkatnya kegagalan pengobatan, epidemi penularan TB dan TB Resisten Obat. Penyebab terbesar dari kegagalan pengobatan adalah putus berobat (DO). Faktor utama penyebab DO yaitu komunikasi antara petugas dengan pasien. System monitoring berfungsi memastikan layanan kesehatan berjalan sesuai prosedur termasuk pengawasan terhadap kepatuhan pengobatan pasien TB. Tujuan penulisan ini untuk mengetahui faktor penyebab putus berobat pasien TB dari segi petugas kesehatan serta mengetahui efektifitas fungsi monitoring dalam meningkatkan kepatuhan pengobatan TB. Kepuasaan pasien terhadap layanan TB yang diterima adalah kunci keberhasilan pengobatan. Kekurangan tenaga dan peningkatan beban kerja dilayanan TB menyebabkan standart kualitas pelayanan belum optimal. Komunikasi antara dokter dan pasien gagal tercipta sehingga tidak ada motivasi penting bagi pasien dalam mematuhi pengobatan. Manager kasus dalam unit klinis berperan penting dalam mengatasi kesenjangan komunikasi dan persepsi antara pasien dengan pemberi layanan. Sepertiga dari pasien DO memutuskan memilih melanjutkan pengobatan non DOTS berisiko berkembang menjadi TB MDR. Buruknya sistem transfer pasien antar faskes menyebabkan pasien TB sulit terlacak pengobatannya. Monitoring dari rekaman medis dan formulir TB untuk memastikan terisi dengan benar dan tepat waktu tidak dilakukan rutin dan berkala. Tidak dilakukan evaluasi monitoring dari pelaksanaan tindak lanjut hasil temuan. Teknologi informasi terbatas pada pelaporan TB ke tingkat pusat sedangkan teknologi reminder belum menjadi pilihan inovasi. Pemberi layanan TB belum meberikan pelayanan yang bermutu. Monitoring belum berjalan dengan baik karena terbatas sumberdaya. Penggunaan teknologi tinggi untuk monitoring belum menjadi inovasi Pemerintah Jateng dalam mengatasi kepatuhan pengobatan TB. Intervensi yang dilakukan harus komprehensif dan multitarget, antara lain peningkatan konseling dan komunikasi antara dokter dengan pasien, pendidikan dan pelatihan manager kasus, desentralisasi pengobatan, dan monitoring rutin dan berkala terstandart.
Evaluation of solid waste management system in ‘X’ hospital, Cilegon city, Banten
Authors: Ferial Linardita , Kosasih Budi Rahayu 
Published: August 2018

Health service activities by the hospital produce a waste of any activity in the form of medical activities and non-medical activities. The purpose of this research is to analyze the solid waste management system in 'X' Hospital, Cilegon City, Banten. The result showed that the source of solid waste generated were classified into 2 types, namely 2% of medical waste and 98% non medical, where the waste treatment process included sorting, characteristic wastage, transporting garbage to TPS, weighing, temporary storage and transportation. The method of handling solid, B3 and domestic solid waste in 'X' Hospital is done in each unit which is sorting according to its characteristic, but still finding the placement of waste which is not in accordance with its characteristic and solid waste processing process is not done by the hospital but given to a third party. Therefore, it can be concluded that the effort to evaluate the solid waste management of 'X' Hospital must refer to the Decree of the Minister of Health of the Republic of Indonesia Number 1204 / Menkes/ SK / X / 2004 on Hospital Health Requirements and need to improve supervision and good cooperation with nurses and janitors in the separation of medical and non-medical waste.
“Ain’t Nobody Got Time for That!”: Framing and Stereotyping in Legacy and Social Media
Authors: Dobson Kathy , Knezevic Irena 
Published: August 2018

Background Social media can be powerful tools for rallying support for a social cause, political mobilization, and social commentary. They can also greatly contribute to incendiary discourses and social stereotypes—often through memes. This article explores the case of one American, known by the moniker of “Sweet Brown,” whose interview about a local fire made her an overnight celebrity in 2012.Analysis A frame analysis of her portrayals in legacy and social media is conducted, and reveals that social media platforms facilitate and even encourage a reductionist approach to messaging.Conclusion and implications Sweet Brown’s appearance, which conjures gender, race, and socio-economic class, became a powerful tool for circulating stereotypes. The interplay between legacy and social media can serve to reproduce stereotypes and marginalization, as is evident in the case of Sweet Brown.Contexte Les médias sociaux peuvent être un outil puissant servant à gagner des appuis pour des causes sociales, la mobilisation politique et des commentaires sociaux. Cependant, ils peuvent aussi véhiculer des propos incendiaires et des stéréotypes sociaux, souvent au moyen de mèmes. Cet article explore le cas d’une Américaine surnommée Sweet Brown, qu’une interview sur un incendie local a subitement rendue célèbre en 2012.Analyse L’article comporte une analyse de cadre sur la manière dont les médias traditionnels et sociaux ont dépeint Sweet Brown. Cette analyse suggère que les médias sociaux facilitent et même encouragent une approche réductionniste.Conclusion et implications L’apparence de Sweet Brown, qui évoque le genre, la race et la classe socioéconomique, est devenue un outil puissant pour faire circuler des stéréotypes. Son cas montre que l’interaction entre médias traditionnels et médias sociaux peut contribuer à la reproduction de stéréotypes et à la marginalisation.
Comparison of Whitening Dentifrices on the Effectiveness of In-office Tooth Bleaching: A Double-blind Randomized Controlled Clinical Trial
Authors: Jiang N , Zhang C , Agingu C , Attin T , Cheng H , Yu H 
Published: August 2018

SUMMARY

Objectives:
To investigate the effect of whitening dentifrices on the effectiveness of in-office tooth bleaching.

Methods and Materials:
A double-blind randomized controlled clinical trial was performed. The participants were randomly allocated into three groups according to the different dentifrices used during this clinical trial: regular dentifrice (group C), conventional whitening dentifrice (group CW), and whitening dentifrice containing blue covarine (group CU). All participants received in-office tooth bleaching for the maxillary anterior teeth (two sessions conducted at a one-week interval). Tooth color was measured with a spectrophotometer at baseline (T1), after the first bleaching session (T2), after the second bleaching session (T3); one week after the completion of in-office bleaching (T4); and three weeks after the completion of in-office bleaching (T5). The data were statistically analyzed through repeated analysis of variance and the Tukey test (α=0.05).

Results:
Sixty participants completed the study (n=20 per group). At T3, group CU exhibited the lowest ΔE values (p=0.008). The ΔE values increased from T4 to T5 in the CW and CU groups, whereas a decrease in ΔE values was observed for group C.

Conclusions:
The use of a whitening dentifrice containing blue covarine during in-office bleaching reduced color changes. After tooth bleaching, brighter tooth colors were observed in the participants who brushed with whitening dentifrices compared to those who brushed with a regular dentifrice.
Effect of Active Application on Bond Durability of Universal Adhesives
Authors: Moritake N , Takamizawa T , Ishii R , Tsujimoto A , Barkmeier WW , Latta MA , Miyazaki M 
Published: August 2018

SUMMARY
The purpose of this study was to determine the effect of different adhesive application methods and etching modes on the dentin bond durability of universal adhesives under thermal cycling (TC). All-Bond Universal (Bisco), Adhese Universal (Ivoclar Vivadent), and Scotchbond Universal (3M ESPE) were used as adhesives. In total, 600 bovine teeth with exposed dentin were divided into 12 groups according to the type of adhesive and subjected to the following bonding procedures: 1) etch-and-rinse mode with active application; 2) etch-and-rinse mode with inactive application; 3) self-etch mode with active application; and 4) self-etch mode with inactive application. Bonded specimens were stored in distilled water at 37°C for 24 hours and then subjected to 5000, 10,000, 30,000, or 50,000 TC between 5°C and 55°C before shear bond strength (SBS) testing, creating a division into a total of five different storage conditions. Baseline specimens were stored in distilled water at 37°C for 24 hours. The SBS test was performed at a cross-head speed of 1.0 mm/min. Three-way analysis of variance revealed that all the factors of application mode, adhesive, and thermal cycle period significantly influenced the SBS values (p&lt;0.001), regardless of the etching mode. In the baseline groups, all of the tested adhesives with active application had higher SBS values than those with inactive application, regardless of etching mode. In the TC groups, significantly lower SBS values were observed at 50,000 TC with inactive application compared to those with active application, regardless of the etching mode. From the scanning electron microscopy observation of demineralized and deproteinized resin/dentin interfaces, dense resin tags longer than 50 μm were observed in the etch-and-rinse with active application group. On the other hand, the resin tags in self-etch mode were sparse, thin, and much shorter than those in etch-and-rinse mode. Comparing the penetration status of the resin tags with active and inactive application in self-etch mode, the resin tag penetration with inactive application was much lower than that with active application. Active application is effective in enhancing the dentin bond durability of universal adhesives. When using universal adhesives with different etching modes, practitioners should select the optimal etching mode and appropriate application method in accordance with the cavity conditions.