bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyclad phylogeny persists to be problematic
Authors: Dittmann Isabel L. , Cuadrado Daniel , Aguado Maria Teresa , Noreña Carolina , Egger Bernhard 
Published: September 2019

AbstractTwo conflicting morphological approaches to polyclad systematics highlight the relevance of molecular data for resolving the interrelationships of Polycladida. In the present study, phylogenetic trees were reconstructed based on a short alignment of the 28S rDNA marker gene with 118 polyclad terminals (24 new) including 100 different polyclad species from 44 genera and 22 families, as well as on a combined dataset using 18S and 28S rDNA genes with 27 polyclad terminals (19 new) covering 26 different polyclad species. In both approaches, Theamatidae and Cestoplanidae were included, two families that have previously been shown to switch from Acotylea to Cotylea. Three different alignment methods were used, both with and without alignment curation by Gblocks, and all alignments were subjected to Bayesian inference and maximum likelihood tree calculations. Over all trees of the combined dataset, an extended majority-rule consensus tree had weak support for Theamatidae and Cestoplanidae as acotyleans, and also the cotylean generaBoninia,ChromyellaandPericelisappeared as acotyleans. With the most inclusive short 28S dataset, on the other hand, there is good support for the aforementioned taxa as cotyleans. Especially with the short 28S matrix, taxon sampling, outgroup selection, alignment method and curation, as well as model choice were all decisive for tree topology. Well-supported parts of the phylogeny over all trees include Pseudocerotoidea, Prosthiostomoidea, Stylochoidea, Leptoplanoidea and Cryptoceloidea, the latter three with new definitions. Unstable positions in the tree were found not only for Theamatidae, Cestoplanidae,Boninia,ChromyellaandPericelis, but also forAnonymus,ChromoplanaandCycloporus.
Persistent Precarity and the Disaster of Everyday Life: Homeless People’s Experiences of Natural and Other Hazards
Authors: Gaillard J C , Walters Vicky , Rickerby Megan , Shi Yu 
Published: September 2019

AbstractKnowledge of how homeless people deal with natural hazards and disasters is sparse and there is a remarkable absence of homeless people in policies and practices for disaster risk reduction (DRR). This article aims at filling this gap by exploring the lives of homeless people in two New Zealand cities that are exposed to natural hazards. It shows that natural hazards are of marginal concern to homeless people in comparison to the everyday hazards that they experience and that make their everyday life a disaster in itself. The disaster of everyday life is created and compounded by homeless people’s precarious lifeworlds. The article, nonetheless, shows that homeless people’s vulnerability to natural hazards remains high as they lack power to control the processes that shape their everyday lives, to prepare for large-scale events, and to be represented in DRR policy. Therefore, the article ultimately argues that disaster policies require greater attention to be paid to the power structures that create persistent precarity and the ways in which this is experienced in everyday life.
Households’ Willingness to Pay for Disaster Resilient Safe Drinking Water Sources in Southwestern Coastal Bangladesh
Authors: Islam Md. Sariful , Afrin Sonia , Ahsan Md. Nasif , Haider Mohammed Ziaul , Mamun Tasnim Murad , Das Debasish Kumar 
Published: September 2019

Abstract
Nonfunctionality of engineered water sources after two catastrophic cyclones—Sidr in November 2007 and Aila in May 2009—created acute scarcity of safe drinking water in coastal Bangladesh. The objective of this study was to estimate households’ willingness to pay (WTP) for disaster resilient water sources in Dacope upazila of Khulna District in southwestern coastal Bangladesh. By applying the double bounded dichotomous contingent valuation method to a dataset of 250 randomly selected households, we found that the mean WTP is BDT 263 and that inaccessibility to functional safe drinking water sources is the most significant determining factor of households’ WTP. Projecting mean WTP for a disaster resilient water source project in the study area, we measured a present value of aggregate WTP over project’s life span worth about BDT 624 (USD 7.37) million, which is about 14.30 times the present value of project’s aggregate establishment and maintenance cost. However, charging the local inhabitants a water tariff at mean WTP would lead to the exclusion of around 50% of the people from getting access to the improved water services or create a free riding problem. Through simulation exercises this study determined that the socially optimal water tariff is BDT 50 per month. This tariff would not only generate revenue of more than five times the project cost but would also create access to disaster resilient improved drinking water sources for almost 99% of the people.
Topical Bromfenac Sodium in Femtosecond Laser-Assisted Cataract Surgery
Authors: Aguilar Sierra María Camila , Alvarado-Villacorta Rosa , Pastrana Claudia Palacio 
Published: September 2019

Purpose:
To evaluate the effect of preoperative 0.09% bromfenac ophthalmic solution for the reduction of intraoperative miosis and pain in patients who have undergone femtosecond laser-assisted cataract surgery.

Methods:
This prospective randomized clinical study included 65 patients with senile cataracts in the absence of significant ocular comorbidity. The patients received 0.09% bromfenac ophthalmic solution or control placebo twice a day for 3 days before surgery. Pupil diameter was measured at the initiation and finalization of femtosecond laser-assisted cataract surgery, and pain quantification was assessed by an analogous pain scale after one day of follow-up.

Results:
A total of 65 patients were randomly divided into two groups. Five patients were excluded due to defective coupling with the laser interface. Each of the 60 patients was randomized to receive preoperative topical treatment with either 0.09% bromfenac or 0.1% sodium hyaluronate. Baseline characteristics were similar between groups for age and gender. The mean change in horizontal and vertical pupil diameter from the preoperative to post-femtosecond laser measurements were significantly less in the bromfenac group than in the placebo group (0.43 ± 0.6 vs. 1.71 ± 0.9, P < 0.001 and 0.40 ± 0.6 vs. 1.78 ± 0.9, P < 0.001, respectively). Compared with untreated patients, the quantification of pain one day after the procedure was significantly lower in the 0.09% bromfenac group (46.7% with a score of 3 vs. 50% with a score of 1, P < 0.001, respectively).

Conclusions:
The maintenance of pupil dilation and the prevention of miosis were more effective in the 0.09% bromfenac group than in the control group. Likewise, the greater control of postoperative pain represented an additional significant benefit.
Choosing Wisely Canada's emergency medicine recommendations: Time for a revision
Authors: Cheng Amy H. Y. , Campbell Sam , Chartier Lucas B. , Dowling Shawn , Goddard Tom , Gosselin Sophie , Holroyd Brian R. , Kapur Atul K. , Magee Kirk , McEwen Jill , Thiruganasambandamoorthy Venkatesh , Upadhye Suneel , Rowe Brian H. 
Published: September 2019

ABSTRACTChoosing Wisely Canada (CWC) is a national initiative designed to encourage patient-clinician discussions about the appropriate, evidence-based use of medical tests, procedures and treatments. The Canadian Association of Emergency Physicians’ (CAEP) Choosing Wisely Canada (CWC) working group developed and released ten recommendations relevant to Emergency Medicine in June 2015 (items 1–5) and October 2016 (items 6–10). In November 2016, the CAEP CWC working group developed a process for updating the recommendations. This process involves: 1) Using GRADE to evaluate the quality of evidence, 2) reviewing relevant recommendations on an ad hoc basis as new evidence emerges, and 3) reviewing all recommendations every five years. While the full review of the CWC recommendations will be performed in 2020, a number of high-impact studies were published after our initial launch that prompted an ad hoc review of the relevant three of our ten recommendations prior to the full review in 2020. This paper describes the results of the CAEP CWC working group's ad hoc review of three of our ten recommendations in light of recent publications.
Slavery, Absorption, and Gender: Frederick Cooper and the Power of Comparison
Authors: Lindsay Lisa A. 
Published: September 2019

Abstract:This essay considers Frederick Cooper’s early scholarship on African slavery, which called for and modeled a practice of comparative historiography. His critique of the “absorption model” of African slavery, enabled by comparison with the Americas, anticipated important recent trends in the study of Atlantic slavery. Revisiting this critique helps us to understand key features of cultural continuity and change among enslaved people and can inform future research about gender and the Atlantic slave trade. In particular, it suggests the limitations of an analysis that separates the assumed African assimilation of enslaved women from the export mostly of men.
Hospital-level high-risk antibiotic use in relation to hospital-associated Clostridioides difficile infections: Retrospective analysis of 2016–2017 data from US hospitals
Authors: Tabak Ying P. , Srinivasan Arjun , Yu Kalvin C. , Kurtz Stephen G. , Gupta Vikas , Gelone Steven , Scoble Patrick J. , McDonald L. Clifford 
Published: September 2019

AbstractObjective:Antibiotics are widely used by all specialties in the hospital setting. We evaluated previously defined high-risk antibiotic use in relation to Clostridioides difficile infections (CDIs).Methods:We analyzed 2016–2017 data from 171 hospitals. High-risk antibiotics included second-, third-, and fourth-generation cephalosporins, fluoroquinolones, carbapenems, and lincosamides. A CDI case was a positive stool C. difficile toxin or molecular assay result from a patient without a positive result in the previous 8 weeks. Hospital-associated (HA) CDI cases included specimens collected >3 calendar days after admission or ≤3 calendar days from a patient with a prior same-hospital discharge within 28 days. We used the multivariable Poisson regression model to estimate the relative risk (RR) of high-risk antibiotic use on HA CDI, controlling for confounders.Results:The median days of therapy for high-risk antibiotic use was 241.2 (interquartile range [IQR], 192.6–295.2) per 1,000 days present; the overall HA CDI rate was 33 (IQR, 24–43) per 10,000 admissions. The overall correlation of high-risk antibiotic use and HA CDI was 0.22 (P = .003), and higher correlation was observed in teaching hospitals (0.38; P = .002). For every 100-day (per 1,000 days present) increase in high-risk antibiotic therapy, there was a 12% increase in HA CDI (RR, 1.12; 95% CI, 1.04–1.21; P = .002) after adjusting for confounders.Conclusions:High-risk antibiotic use is an independent predictor of HA CDI. This assessment of poststewardship implementation in the United States highlights the importance of tracking trends of antimicrobial use over time as it relates to CDI.
Efficient Wine Pricing Using Stochastic Frontier Models
Authors: Fried Harold O. , Tauer Loren W. 
Published: September 2019

AbstractWe specify a two-tier stochastic frontier model to estimate a price equation for U.S. Rieslings and determine overpricing and underpricing of specific wines. The data is for 2000–2016. Using tasting score and tasting score squared as sole independent variables, we found evidence of overpricing and underpricing of wines. When additional location variables were entered, empirical estimates for this two-tier model were infeasible, suggesting that both underpricing and overpricing did not occur simultaneously in this market. Separate one-sided stochastic frontier models were then specified and estimated to test for either under or overpricing in this market. Results showed that overpricing exists and not underpricing, but the extent of overpricing is minor, suggesting that wineries do an efficient job pricing their wines, given tasting scores, conditional on regional location premiums or discounts. We also investigated the effect of scale on pricing for a smaller set of wineries. (JEL Classifications: C4, D4, Q1)
Vowel duration in English adjectives in attributive and predicative constructions
Authors: BYBEE JOAN , NAPOLEÃO DE SOUZA RICARDO 
Published: September 2019

abstractUsing ten English adjectives, this study tests the hypothesis that the vowels in adjectives in predicative constructions are longer than those in attributive constructions in spoken conversation. The analyses considered a number of factors: occurrence before a pause, lexical adjective, vowel identity, probability given surrounding words, and others. Two sets of statistical techniques were used: a Mixed-effects model and the Random Forest Analysis based on Conditional Inference Trees (CIT). Both analyses showed strong effects of predicative vs. attributive constructions and individual lexical adjectives on vowel duration in the predicted direction, as well as effects of many of the phonological variables tested. The results showed that the longer duration in the predicative construction is not due to lengthening before a pause, though it is related to whether the adjective is internal or final in the predicative construction. Nor is the effect attributable solely to the probability of the occurrence of the adjective; rather construction type has to be taken into account. The two statistical techniques complement each other, with the Mixed-effects model showing very general trends over all the data, and the Random Forest / CIT analysis showing factors that affect only subsets of the data.
The End of the “Green Oasis”: Chronological Bayesian Modeling of Human and Environmental Dynamics in the Bahariya Area (Egyptian Sahara) from Pharaonic Third Intermediate Period to Medieval Times
Authors: Colin Frédéric , Quiles Anita , Schuster Mathieu , Schwartz Dominique , Duvette Catherine , Marchand Sylvie , El Dorry Mennat-Allah , van Heesch Johan 
Published: September 2019

ABSTRACTAfter the sharp transition to aridity that followed the “Green Sahara” episode 5500 years ago, human settlements took refuge in Egyptian oases, which have to varying extents been “Green Oases” for centuries. In that period, synchronous with the beginning of historical times, the desert’s aridity is generally regarded as broadly comparable to the current period. Natural and anthropogenic deposits studied during 13 excavation campaigns in Bahariya Oasis (Egyptian Desert) suggest that a fairly clear transition from a relatively green environment to much more arid landscapes occurred in the first millennia BCE and CE. This article aims at establishing the chronology of human occupations and environmental change within this period, by combining archaeological and radiocarbon data, using Bayesian modeling. It reveals that the drying up of the environment experienced by desert farmers occurred at some point between the reigns of Antoninus Pius and Caracalla (2nd–3rd century CE). The accuracy of the produced chronological models made it possible to highlight synchronisms between the end of this “Green Oasis” phase and comparable aridification phenomena on regional and interregional scales. Similar degradation processes on remote sites inside the Roman Empire might be explained by globalized anthropogenic agencies overlapping with a broader climatic drying.
The Compound Effects of Candidate Race and Racial Resentment in US House Elections
Authors: Hale Isaac 
Published: September 2019

AbstractDespite the longstanding underrepresentation of blacks in Congress, political science research has not settled on the cause. While there is increasing evidence that racial attitudes affect vote choice in today's congressional elections, how this effect interacts with the race of the candidates is unknown. This study addresses this debate by analyzing novel survey, census, and candidate data from the Obama era of congressional elections (2010–2016) to test whether racially prejudiced attitudes held by whites decrease their likelihood of supporting black Democratic candidates and Democratic candidates as a whole. In line with theoretical predictions, this paper finds that Democratic House candidates are less likely to receive votes among white voters with strong racial resentment toward blacks, and black Democratic candidates fare even worse. These findings help to explain the persistence of black legislative underrepresentation and contribute to theories of partisan racial realignment.
Effect of flaxseed oil on muscle protein loss and carbohydrate oxidation impairment in a pig model after lipopolysaccharide challenge
Authors: Kang Ping , Wang Yang , Li Xiangen , Wan Zhicheng , Wang Xiuying , Zhu Huiling , Wang Chunwei , Zhao Shengjun , Chen Huifu , Liu Yulan 
Published: September 2019

AbstractFlaxseed oil is rich in α-linolenic acid (ALA), which is the metabolic precursor of EPA and DHA. The present study investigated the effect of flaxseed oil supplementation on lipopolysaccharide (LPS)-induced muscle atrophy and carbohydrate oxidation impairment in a piglet model. Twenty-four weaned pigs were used in a 2 × 2 factorial experiment including dietary treatment (5 % maize oilv. 5 % flaxseed oil) and LPS challenge (salinev. LPS). On day 21 of treatment, the pigs were injected intraperitoneally with 100 μg/kg body weight LPS or sterile saline. At 4 h after injection, blood, gastrocnemius muscle and longissimus dorsi muscle were collected. Flaxseed oil supplementation increased ALA, EPA, totaln-3 PUFA contents, protein:DNA ratio and pyruvate dehydrogenase complex quantity in muscles (P< 0·05). In addition, flaxseed oil reduced mRNA expression of toll-like receptor (TLR) 4 and nucleotide-binding oligomerisation domain protein (NOD) 2 and their downstream signalling molecules in muscles and decreased plasma concentrations of TNF-α, IL-6 and IL-8, and mRNA expression of TNF-α, IL-1βand IL-6 (P< 0·05). Moreover, flaxseed oil inclusion increased the ratios of phosphorylated protein kinase B (Akt) 1:total Akt1 and phosphorylated Forkhead box O (FOXO) 1:total FOXO1 and reduced mRNA expression of FOXO1, muscle RING finger (MuRF) 1 and pyruvate dehydrogenase kinase 4 in muscles (P< 0·05). These results suggest that flaxseed oil might have a positive effect on alleviating muscle protein loss and carbohydrates oxidation impairment induced by LPS challenge through regulation of the TLR4/NOD and Akt/FOXO signalling pathways.
Simulations of carbon ion acceleration by 10 PW laser pulses on ELI-NP
Authors: Sangwan D. , Culfa O. , Ridgers C.P. , Aogaki S. , Stutman D. , Diaconescu B. 
Published: September 2019

AbstractWe present results of 2D particle-in-cell (PIC) simulations of carbon ion acceleration by 10 petawatt (PW) laser pulses, studying both circular polarized (CP) and linear polarized (LP) pulses. We carry out a thickness scanning of a solid carbon target to investigate the ideal thickness for carbon ion acceleration mechanisms using a 10 PW laser with an irradiance of 5 × 1022 W cm−2. The energy spectra of carbon ions and electrons and their temperature are studied. Additionally, for the carbon ions, their angular divergence is studied. It is shown that the ideal thickness for the carbon acceleration is 120 nm and the cutoff energy for carbon ions is 5 and 3 GeV for CP and LP pulses, respectively. The corresponding carbon ions temperature is ~1 and ~0.75 GeV. On the other hand, the energy cutoff for the electrons is ~500 MeV with LP and ~400 MeV with CP laser pulses. We report that the breakout afterburner mechanism is most likely causing the acceleration of carbon ions to such high energies for the optimal target thickness.
Health Technology Agency insights: informing modification of a qualitative benefit risk framework for Health Technology Reassessment of prescription medications
Authors: Maloney Mary Alison , Schwartz Lisa , O'Reilly Daria , Levine Mitchel 
Published: September 2019

AbstractObjectivesThis study's intent was to determine if a qualitative benefit risk framework could be used or modified to further enable Health Technology Reassessment (HTR) of prescription medicine recommendations. The purpose of this research was to understand Canadian Health Technology Agency assessors past experiences and insights to inform any modifications to the Universal Methodology for Benefit−Risk Assessment (UMBRA) qualitative framework. The UMBRA framework consists of an eight-step process, used during the assessment phase, to aid in decision making and dissemination.MethodsA qualitative descriptive study was conducted and included a purposeful, criterion-based sample of eight assessors who had participated in Health Technology Assessment (HTA) or HTR for prescription medicines or in qualitative decision-making frameworks.ResultsParticipant interviews lead to four common themes: “adoption of a qualitative benefit risk framework,” “data (either too much or not enough),” “importance of incorporating stakeholder values,” and “feasibility of the UMBRA framework.” Methodological challenges with HTR were highlighted including the lack of clinical outcome data and the ability to compare clinically relevant meaningful differences. The implementation of a ranking or weighing process found within the UMBRA framework was not favored by half of the participants.ConclusionsResearch participants did not consider all steps of the UMBRA framework to be transferable to the assessment phase of HTR given the need for simplicity, resource efficiency, and stakeholder input throughout the process. The assessor experiences and insights and the resultant key themes can be used in future research to aid in the development of a qualitative recommendation framework for HTR.
WHY ARE LEXICAL TONES DIFFICULT TO LEARN?
Authors: Chan Ricky KW , Leung Janny HC 
Published: September 2019

AbstractL2 sounds present different kinds of challenges to learners at the phonetic, phonological, and lexical levels, but previous studies on L2 tone learning mostly focused on the phonetic and lexical levels. The present study employs an innovative technique to examine the role of prior tonal experience and musical training on forming novel abstract syllable-level tone categories. Eighty Cantonese and English musicians and nonmusicians completed two tasks: (a) AX tone discrimination and (b) incidental learning of artificial tone-segment connections (e.g., words beginning with an aspirated stop always carry a rising tone) with synthesized stimuli modeled on Thai. Although the four participant groups distinguished the target tones similarly well, Cantonese speakers showed abstract and implicit knowledge of the target tone-segment mappings after training but English speakers did not, regardless of their musical experience. This suggests that tone language experience, but not musical experience, is crucial for forming novel abstract syllable-level tone categories.