bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory and clinical risk assessment to treat myelodysplatic syndromes
Authors: Gidaro Antonio , Deliliers Giorgio Lambertenghi , Gallipoli Paolo , Arquati Massimo , Wu Maddalena Alessandra , Castelli Roberto 
Published: December 2018

AbstractMyelodisplastic syndromes (MDS) are heterogeneous myeloid disorders characterized by peripheral cytopenias and increased risk of transformation into acute myelogenous leukemia (AML). MDS are generally suspected in the presence of cytopenia on routine analysis and the evaluation of bone marrow cells morphology and cellularity leads to correct diagnosis of MDS. The incidence of MDS is approximately five cases per 100,000 people per year in the general population, but it increases up to 50 cases per 100,000 people per year after 60 years of age. Typically MDS affect the elderly, with a median age at diagnosis of 65–70 years. Here the current therapeutic approaches for MDS are evaluated by searching the PubMed database. Establishing the prognosis in MDS patients is a key element of therapy. In fact an accurate estimate of prognosis drives decisions about the choice and timing of the therapeutic options. Therapy is selected based on prognostic risk assessment, cytogenetic pattern, transfusion needs and biological characteristics of the disease, comorbidities and clinical condition of the patients. In lower-risk patients the goals of therapy are different from those in higher-risk patients. In lower-risk patients, the aim of therapy is to reduce transfusion needs and transformation to higher risk disease or AML, improving the quality of life and survival. In higher-risk patients, the main goal of therapy is to prolong survival and to reduce the risk of AML transformation. Current therapies include growth factor support, lenalidomide, immunomodulatory and hypomethylating agents, intensive chemotherapy, and allogenic stem cell transplantation. The challenge when dealing with MDS patients is to select the optimal treatment by balancing efficacy and toxicity.
Degrowth wächst an Geschlechterperspektiven: Genderaspekte in Degrowth-Konzeptionen und -Praxis
Authors: Dannemann Hauke , Holthaus Anna 
Published: December 2018

AbstractTrotz zunehmender Anstrengungen finden Genderaspekte der Gestaltung gesellschaftlicher Naturverhältnisse in deutschsprachigen Debatten um Postwachstum und Degrowth wenig Beachtung. In diesem Artikel werden diesbezügliche Leerstellen sowohl auf konzeptioneller Ebene am Beispiel der Postwachstumsökonomik und -ökonomie Niko Peachs als auch in der Praxis der Degrowthbewegung anhand empirischer Forschungsergebnisse in Deutschland aufgezeigt. Ihnen werden Potentiale feministischer Forschung und Praxis für Degrowthkonzepte und -bewegung gegenübergestellt, um die Forderung nach einer emanzipatorischen sozial-ökologischen Transformation, die auch notwendig auf die Überwindung patriarchaler Geschlechterverhältnisse zielen muss, zu Zeiten gesellschaftlicher Regressionstendenzen zu bestärken.
LncRNA TINCR/microRNA-107/CD36 regulates cell proliferation and apoptosis in colorectal cancer via PPAR signaling pathway based on bioinformatics analysis
Authors: Zhang Xuexiu , Yao Jianning , Shi Haoling , Gao Bing , Zhang Lianfeng 
Published: December 2018

Abstract
The present study aims to determine the potential biomarkers and uncover the regulatory mechanisms of the long-noncoding RNA (lncRNA) TINCR/miR-107/CD36 axis in colorectal cancer (CRC). Aberrantly-expressed lncRNAs and differential-expressed genes were identified by analyzing the dataset GSE40967. Gene set enrichment analysis was employed, and Cytoscape software helped in establishing the co-expression network between lncRNAs and genes. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis contributes to examining the expression levels of lncRNA TINCR, miR-107 and CD36. The dual luciferase assay was used to validate the association between miR-107 and lncRNA TINCR or CD36. The EdU incorporation assay was employed, and flow cytometry was employed to detect cell apoptosis with the tumor xenograft model being utilized. Significantly dysregulated lncRNAs and mRNAs were identified. The peroxisome proliferator-activated receptor (PPAR) signaling pathway in CRC tissues was down-regulated. The loss of TINCR expression was associated with CRC progression. The expression levels of the TINCR and CD36 were down-regulated. We identified miR-107 as an inhibitory target of TINCR and CD36. Overexpression of TINCR could inhibit cell proliferation and promote apoptosis. MiR-107 overexpression in CRC cells induced proliferation and impeded apoptosis. A regulatory function of the lncRNA TINCR/miR-107/CD36 axis in CRC was revealed. LncRNA TINCR overexpression exerted suppressive influence on CRC progression through modulating the PPAR signaling pathway via the miR-107/CD36 axis.
Kinetically selective and potent inhibitors of HDAC8
Authors: Schweipert Markus , Jänsch Niklas , Sugiarto Wisely Oki , Meyer-Almes Franz-Josef 
Published: December 2018

Abstract
Histone deacetylase 8 (HDAC8) is an established and validated target for T-cell lymphoma and childhood neuroblastoma. The active site binding pocket of HDAC8 is highly conserved among all zinc-containing representatives of the histone deacetylase (HDAC) family. This explains that most HDACs are unselectively recognized by similar inhibitors featuring a zinc binding group (ZBG), a hydrophobic linker and a head group. In the light of this difficulty, the creation of isoenzyme-selectivity is one of the major challenges in the development of HDAC inhibitors. In a series of trifluoromethylketone inhibitors of HDAC8 compound 10 shows a distinct binding mechanism and a dramatically increased residence time (RT) providing kinetic selectivity against HDAC4. Combining the binding kinetics results with computational docking and binding site flexibility analysis suggests that 10 occupies the conserved catalytic site as well as an adjacent transient sub-pocket of HDAC8.
The Hybrid Real-Time Dispatcher Training Simulator: Basic Approach, Software-Hardware Structure and Case Study
Authors: Suvorov Aleksey , Gusev Alexander , Ruban Nikolay , Andreev Mikhail , Askarov Alisher , Stavitsky Sergey 
Published: December 2018

AbstractThe article presents the Hybrid Real-Time Dispatcher Training Simulator (HRTDTS). The main advantages of this simulator are the adequate simulation of a single spectrum of processes in the object for training – any real electric power system (EPS), as well as the real-time control of the equipment circuit-mode states in modes of the EPS operation. This is achieved by the HRTDTS development within the concept of hybrid simulation, which allows to surpass the modern widely-used simulators based purely on numerical simulation, which do not comprehensively reproduce processes in the EPS and limit the training of certain dispatchers skills. The dispatcher simulator structure and the developed specialized HRTDTS software are demonstrated. The developed dynamic dashboards for monitoring and operating, implementing the circuit-mode states visualization of the equipment or the EPS districts that correspond to specific objects for training, are presented. The special panels that display extended information about the processes in the EPS are also shown in the article. The comparison of simulation results with the data, obtained via RTDS, for the HRTDTS validation was carried out. The practical emergency scenario for the training of dispatching personnel, including the assignment of an emergency situation and the actions of dispatchers to eliminate it, was created for testing and demonstration of the HRTDTS capabilities.
Suicide in the Phaedo
Authors: Werner Daniel 
Published: December 2018

Abstract
In the Phaedo the character Socrates argues that suicide is morally wrong. This is in fact one of only two places in the entire Platonic corpus where suicide is discussed. It is a brief passage, and a notoriously perplexing one. In this article, I distinguish between two arguments that Socrates gives in support of his claim. I argue that one of them (what I call the Gods Argument) is not to be taken literally, while the other (what I call the Prison Argument) represents the deeper reason for the prohibition of suicide. I further relate the question of suicide to the overarching concerns of the Phaedo as a whole: the nature of our incarnate “imprisonment”, the nature and purpose of philosophy, the philosophical “purification” of the soul, the human pursuit of knowledge, and the nature of the divine.
Beutekunst und Kunstraub
Authors: Grelka Frank 
Published: December 2018

Vorspann
Zu den ungelösten Folgeproblemen des deutsch-sowjetischen Kriegs gehört der schwierige Komplex von Beutekunst und Kunstrestitution. Trotz langjähriger Verhandlungen konnten beide Seiten hier zu keiner Übereinkunft finden. Frank Grelka untersucht im vorliegenden Aufsatz Konzepte, Ansprüche und die Durch-führung der sowjetischen Kunstrequisition in Deutschland nach dem Zweiten Weltkrieg und kann zeigen, dass diese über das Prinzip der restitution in kind deutlich hinausgingen.
The Greek Text of Revelation in Late Antique Egypt: Materials, Texts, and Social History
Authors: Malik Peter 
Published: December 2018

Abstract
The Book of Revelation has been something of an outlier within parts of the Christian tradition, as evidenced, among other things, by its peculiar canonical reception. As regards the earliest period of transmission, however, the Greek text of Revelation is relatively well attested. In this vein, the present study seeks to examine the relevant Greek materials from late antique Egypt, and thus elucidate the earliest textual and material transmission of this book. The manuscripts in question will be surveyed with a particular focus on their distinctive features such as book formats and scribal practices, as well as textual characteristics, followed by reflections on their socio-historical significance.
Über die thermische Dissoziation des Vakuums Über die thermische Dissoziation des Vakuums
Authors: Houtermans Fritz G. , Hans J. , Jensen D. 
Published: December 2018

Abstract
Wir möchten in dieser Note auf einige Konsequenzen der Positronentheorie hinweisen, bei denen die Notwendigkeit der Erweiterung der Quantentheorie durch die Einführung einer "kleinsten Länge" besonders augenfällig wird. Wie in der Literatur schon mehrfach hervorgehoben wurde 1 , befinden sich in einem "materiefreien" Hohlraum im thermischen Gleichgewicht immer eine Anzahl Elektron-Positron-Paare. Wenn auch bei "normalen Temperaturen" die Zahl solcher Paare sehr gering ist, so steigt sie doch sehr rasch mit der Temperatur an, und bei kT über 137 mc2 (m = Elektronenmasse, c = Lichtgeschwindigkeit) würde schon mehr als ein Paar auf das Elementarvolumen 4 π/3 (e2 /mc2 ) 3 entfallen, so daß sich bei dieser Temperatur ganz zwangsläufig eine "dichteste Packung" von Elementarteilchen ergeben würde (wegen Lorentz-Kontraktion s. 2.). Temperaturen dieser Größenordnung sind schon mehr-fach im Zusammenhang mit kosmologischen Fragen und der Elementen-Häufigkeits-Ver-teilung diskutiert worden; jedoch scheint uns nach dem eben Gesagten die Behandlung dieses Fragenkomplexes ohne direkte Bezugnahme auf das Problem der Elementar-teilchen nicht sinnvoll zu sein. Als weitere Konsequenz der thermischen Dissoziation besitzt das Vakuum eine tem-peraturabhängige Polarisierbarkeit, im Unterschied zu den Voraussetzungen 2 der Dirac-Heisenbergschen Positronentheorie, die sich auf den Fall T = 0 bezieht. Es ergeben sich also Zusatzglieder zur He i senberg-Eulerschen 3 Lagrange-Funktion des elektromagnetischen Feldes, die bereits bei kT = mc2 merklich werden. Eine Coulomb sehe Ladung, etwa ein Atomkern, umgibt sich mit einer Dipolwolke, die freilich bei normalen Temperaturen äußerst schwach und ausgedehnt ist, aber bei kT über mc2 das Coulomb-Feld wesentlich modifiziert.
Zur Deutung der Regelmäßigkeiten in den Spektren substituierter Benzole
Authors: Förster Theodor 
Published: December 2018

Abstract
Einige empirisch lange bekannte Regelmäßigkeiten in den Frequenzen und Intensitäten der ultravioletten Absorptionsspektren substituierter Benzole werden mit Hilfe der quantenmechanischen Valenztheorie gedeutet.
Über den Ablauf zusammengesetzter chemischer Reaktionen Systeme von Reaktionen I. Ordnung
Authors: Jost Wilhelm 
Published: December 2018

Abstract
1. Es kann gezeigt werden, daß in beliebig kompliziert zusammengesetzten chemischen Umwandlungen nach der I. Ordnung keine Periodizität auftreten kann, sofern das Prin-zip der mikroskopischen Reversibilität erfüllt ist.
2. Darüber hinaus gilt die schärfere Aussage: die Konzentration jeder Komponente dieses Systems kann als Funktion der Zeit höchstens (n-2) Extrema durchlaufen, wenn n die Zahl der Komponenten ist. I. E s ist bekannt, daß man bei der Berechnung der
Zur Breit-Wigner-Formel II
Authors: Flügge Siegfried 
Published: December 2018

Abstract
In Fortsetzung einer früheren Arbeit wird die Breit-Wigner-Formel auf den Fall mehrerer Resonanzniveaus erweitert und gezeigt, daß dabei charakteristische Inter-ferenzerscheinungen zwischen den einzelnen Niveaus auftreten, die der experimentellen Erfassung zugänglich sind. Insbesondere wird der Fall eines engen Dubletts diskutiert und gezeigt, daß hierbei durch Interferenzerscheinungen eine sehr schmale und hohe Linie an Stelle zweier normaler zustande kommen kann.
An Efficient Population Density Method for Modeling Neural Networks with Synaptic Dynamics Manifesting Finite Relaxation Time and Short-Term Plasticity
Authors: Huang Chih-Hsu , Lin Chou-Ching K. 
Published: December 2018

AbstractWhen incorporating more realistic synaptic dynamics, the computational efficiency of population density methods (PDMs) declines sharply due to the increase in the dimension of master equations. To avoid such a decline, we develop an efficient PDM, termed colored-synapse PDM (csPDM), in which the dimension of the master equations does not depend on the number of synapse-associated state variables in the underlying network model. Our goal is to allow the PDM to incorporate realistic synaptic dynamics that possesses not only finite relaxation time but also short-term plasticity (STP). The model equations of csPDM are derived based on the diffusion approximation on synaptic dynamics and probability density function methods for Langevin equations with colored noise. Numerical examples, given by simulations of the population dynamics of uncoupled exponential integrate-and-fire (EIF) neurons, show good agreement between the results of csPDM and Monte Carlo simulations (MCSs). Compared to the original full-dimensional PDM (fdPDM), the csPDM reveals more excellent computational efficiency because of the lower dimension of the master equations. In addition, it permits network dynamics to possess the short-term plastic characteristics inherited from plastic synapses. The novel csPDM has potential applicability to any spiking neuron models because of no assumptions on neuronal dynamics, and, more importantly, this is the first report of PDM to successfully encompass short-term facilitation/depression properties.
Coordination between Prefrontal Cortex Clock Gene Expression and Corticosterone Contributes to Enhanced Conditioned Fear Extinction Recall
Authors: Woodruff Elizabeth R. , Chun Lauren E. , Hinds Laura R. , Varra Nicholas M. , Tirado Daniel , Morton Sarah J. , McClung Colleen A. , Spencer Robert L. 
Published: December 2018

AbstractPost-traumatic stress disorder (PTSD) is associated with impaired conditioned fear extinction learning, a ventromedial prefrontal cortex (vmPFC)-dependent process. PTSD is also associated with dysregulation of vmPFC, circadian, and glucocorticoid hormone function. Rats have rhythmic clock gene expression in the vmPFC that requires appropriate diurnal circulatory patterns of corticosterone (CORT), suggesting the presence of CORT-entrained intrinsic circadian clock function within the PFC. We examined the role of vmPFC clock gene expression and its interaction with CORT profiles in regulation of auditory conditioned fear extinction learning. Extinction learning and recall were examined in male rats trained and tested either in the night (active phase) or in the day (inactive phase). Using a viral vector strategy,Per1andPer2clock gene expression were selectively knocked down within the vmPFC. Circulating CORT profiles were manipulated via adrenalectomy (ADX) ± diurnal and acute CORT replacement. Rats trained and tested during the night exhibited superior conditioned fear extinction recall that was absent in rats that had knock-down of vmPFC clock gene expression. Similarly, the superior nighttime extinction recall was absent in ADX rats, but restored in ADX rats given a combination of a diurnal pattern of CORT and acute elevation of CORT during the postextinction training consolidation period. Thus, conditioned fear extinction learning is regulated in a diurnal fashion that requires normal vmPFC clock gene expression and a combination of circadian and training-associated CORT. Strategic manipulation of these factors may enhance the therapeutic outcome of conditioned fear extinction related treatments in the clinical setting.
Origin, Composition, and Structure of the Supernumerary B Chromosome of Drosophila melanogaster
Authors: Hanlon Stacey L , Miller Danny E , Eche Salam , Hawley R Scott 
Published: December 2018

Abstract
In addition to a defined number of essential chromosomes, extra chromosomes called “B chromosomes” are present in roughly 15% of eukaryotic species. In this study, Hanlon et al. analyzed the recently discovered Drosophila melanogaster...
The number of chromosomes carried by an individual species is one of its defining characteristics. Some species, however, can also carry supernumerary chromosomes referred to as B chromosomes. B chromosomes were recently identified in a laboratory stock of Drosophila melanogaster—an established model organism with a wealth of genetic and genomic resources—enabling us to subject them to extensive molecular analysis. We isolated the B chromosomes by pulsed-field gel electrophoresis and determined their composition through next-generation sequencing. Although these B chromosomes carry no known euchromatic sequence, they are rich in transposable elements and long arrays of short nucleotide repeats, the most abundant being the uncharacterized AAGAT satellite repeat. Fluorescent in situ hybridization on metaphase chromosome spreads revealed this repeat is located on chromosome 4, strongly suggesting the origin of the B chromosomes is chromosome 4. Cytological and quantitative comparisons of signal intensity between chromosome 4 and the B chromosomes supports the hypothesis that the structure of the B chromosome is an isochromosome. We also report the identification of a new B chromosome variant in a related laboratory stock. This B chromosome has a similar repeat signature as the original but is smaller and much less prevalent. We examined additional stocks with similar genotypes and did not find B chromosomes, but did find these stocks lacked the AAGAT satellite repeat. Our molecular characterization of D. melanogaster B chromosomes is the first step toward understanding how supernumerary chromosomes arise from essential chromosomes and what may be necessary for their stable inheritance.
Characterization of Autonomous Work in a Chilean English Pedagogy Program: Teachers’ and Freshmen’s Perspectives
Authors: Correa-Pérez Roxanna , Sanhueza-Jara María Gabriela 
Published: December 2018

Autonomy in language learning is recognized as a basic skill language learners need to develop. This study describes the autonomous work activities university students carry out in a first-semester course of an English teaching program, and the amount of time they invest in each of these activities. Moreover, it describes the teachers’ perspective on students’ autonomous work. It is a descriptive mixed study with an exploratory scope. The study considers data generated through the application of a questionnaire and an in-depth interview to 48 freshmen from an English Pedagogy Program, as well as a questionnaire and a focus group applied to eight English teachers from the same program. The qualitative data were analyzed through content analysis method; and the quantitative data, through a frequency method of analysis. The analysis reveals that there is an imbalance between the time teachers estimate students devote to autonomous work and the real time students declare to invest in it. In relation to students autonomous work activities, it can be concluded that they concentrate on activities which are less stressful and the ones they do not need to interact with teachers. This study provides empiric information that could be useful to design courses that consider autonomous work.
Results of endovascular correction of atrial septal defect and early heart remodeling in children of preschool and school age
Authors: Tarasov R. S. , Shushpannikov P. A. , Ganyukov V. I. , Sizova I. N. 
Published: December 2018

Aim. To analyze the results and features of early cardiac remodeling (CR) in children of preschool and school age after endovascular correction of atrial septal defect (ASD).Material and methods. A prospective study included 27 children with secondary ASD who underwent endovascular correction for one year (from the beginning of 2017 to the beginning of 2018). The patients were divided into two groups. The first (n=12) — children of preschool age (<8 years old), mean age 4,5 [3;6], and the second (n=15) — school age (8­18 years old), mean age 12 [9;14]. The following indicants were assessed during hospitalization: the success of the intervention, hospital complications, functional data characterizing CR according to echocardiography before and after the correction of the defect.Results. It was shown that all children successfully completed endovascular closure of ASD. Complications were not identified. We find several statistically significant changes in echocardiogram data before and after the intervention. In the preschool age group, the size of the right ventricle (RV) decreased from 1,66 to 1,45 cm (p=0,028), the right atrium (RA) decreased from 3,58 to 3,1 cm (p=0,003), and the longitudinal size of RV decreased from 3 to 2 cm (p=0,032) and basal size of RV — from 5,98 to 4,4 cm (p=0,005), the volume of RA decreased from 25,7 to 20,7 ml (p=0,005). In the group of school age, the size of the RV changed from 2,08 to 1,8 cm (p=0,038), the size of the RA — from 3,72 to 2,71 cm (p=0,007), the RV area in diastole — from 12,4 to 10,6 mm2. The gradient has changed from 2 to 1,54 mm Hg (p=0,043), the frontal size of the tricuspid valve (TV) decreased from 2,7 to 2,48 cm (p=0,010). The basal size of RV decreased from 3 to 2,6 cm (p=0,015), the median size — from 2,73 to 2,37 cm (p=0,017) and the longitudinal size — from 5,97 to 5,45 cm (p=0,007). No significant differences in CR among the groups were found.Conclusion. We made conclusion about the efficacy and safety of endovascular correction of ASD, which has a positive effect on early HR in children, both in early and in old age.