bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review and meta-analysis comparing outcomes of multi-port versus single-incision laparoscopic surgery (SILS) in Hartmann’s reversal
Authors: Mostafa Omar E. S. , Zaman Shafquat , Beedham William , Kakaniaris Georgios , Husain Najam , Kumar Lalit , Akingboye Akinfemi , Waterland Peter 
Published: November 2024

Abstract
Background
Colostomy formation as part of the Hartmann’s procedure is often performed during emergency surgery as a damage limitation measure where attempts at bowel anastomosis and continuity are contraindicated. Hartmann’s reversal (HR) remains challenging and can be attempted through open surgery and various minimally invasive techniques (laparoscopic and robotic platforms). We aimed to analyse outcomes of conventional multi-port laparoscopy (CL) versus single-incision approach (SILS) in patients undergoing HR.

Methods
A comprehensive online search of various databases was conducted in accordance with PRISMA guidelines including Medline, PubMed, Embase, and Cochrane. Comparative studies of patients undergoing CL and SILS for HR were included. Analysed primary outcomes were total operative time and mortality rate. Secondary outcomes included post-operative complications, length of hospital stay, risk of visceral injury intra-operatively, and re-operation rate. Combined overall effect sizes were calculated using the random-effects model, and the Newcastle–Ottawa Scale (NOS) was used to assess bias.

Results
Two observational studies matching our inclusion criteria with a total of 160 patients (SILS 100 vs. CL 60) were included. Statistical difference was observed for one outcome measure: operative duration (MD − 44.79 CI − 65.54– − 24.04, P < 0.0001). No significant difference was seen in mortality rate (OR 1.66 CI 0.17–16.39, P = 0.66), overall post-operative complications (OR 0.60 CI 0.28–1.32, P = 0.20), length of stay (MD − 0.22 CI − 4.25–3.82, P = 0.92), Clavien-Dindo III + complications (OR 0.61 CI 0.15–2.53, P = 0.50), risk of visceral injury (OR 1.59 CI 0.30–8.31, P = 0.58), and re-operation rates (OR 0.73 CI 0.08–6.76, P = 0.78).

Conclusion
Accounting for study limitations, the SILS procedure seems to be quicker with non-inferior outcomes compared with the conventional multi-port approach. This may lead to better patient satisfaction and cosmesis and potentially reduce the risk of future incisional hernia occurrence. However, well-designed, randomised studies are needed to draw more robust conclusions and recommendations.
Effects of thermal interventions on skeletal muscle adaptations and regeneration: perspectives on epigenetics: a narrative review
Authors: Normand-Gravier Tom , Solsona Robert , Dablainville Valentin , Racinais Sébastien , Borrani Fabio , Bernardi Henri , Sanchez Anthony M. J. 
Published: November 2024

Abstract
Recovery methods, such as thermal interventions, have been developed to promote optimal recovery and maximize long-term training adaptations. However, the beneficial effects of these recovery strategies remain a source of controversy. This narrative review aims to provide a detailed understanding of how cold and heat interventions impact long-term training adaptations. Emphasis is placed on skeletal muscle adaptations, particularly the involvement of signaling pathways regulating protein turnover, ribosome and mitochondrial biogenesis, as well as the critical role of satellite cells in promoting myofiber regeneration following atrophy. The current literature suggests that cold interventions can blunt molecular adaptations (e.g., protein synthesis and satellite cell activation) and oxi-inflammatory responses after resistance exercise, resulting in diminished exercise-induced hypertrophy and lower gains in isometric strength during training protocols. Conversely, heat interventions appear promising for mitigating skeletal muscle degradation during immobilization and atrophy. Indeed, heat treatments (e.g., passive interventions such as sauna-bathing or diathermy) can enhance protein turnover and improve the maintenance of muscle mass in atrophic conditions, although their effects on uninjured skeletal muscles in both humans and rodents remain controversial. Nonetheless, heat treatment may serve as an important tool for attenuating atrophy and preserving mitochondrial function in immobilized or injured athletes. Finally, the potential interplay between exercise, thermal interventions and epigenetics is discussed. Future studies must be encouraged to clarify how repeated thermal interventions (heat and cold) affect long-term exercise training adaptations and to determine the optimal modalities (i.e., method of application, temperature, duration, relative humidity, and timing).
Distinctive features of bimanual coordination in idiopathic normal pressure hydrocephalus
Authors: Umemori Takuma , Kobayashi Kazushige , Watanabe Ryo , Higuchi Takahiro 
Published: November 2024

Abstract

Background
Idiopathic normal pressure hydrocephalus (iNPH) is characterized by cerebrospinal fluid circulation disorders, and presents as gait and balance disturbances similar to those observed in other incurable neurological diseases. Although previous studies have reported deficits in bimanual coordination among patients with iNPH, these potential pathological characteristics have not received much attention to date. This study investigated the temporal characteristics of a bimanual finger-tapping task in patients with iNPH, focusing on within- and between-hand coordination.

Methods
Study participants comprised three groups: patients with iNPH (N = 19, mean age = 76.9 ± 5.6 years), older adults (N = 19, 76.4 ± 5.3 years), and younger adults (N = 13, 32.2 ± 8.5 years). Participants performed a bimanual finger-tapping task under five conditions that manipulated the temporal differences between the two taps.

Results
The iNPH group exhibited significantly greater errors in both within- and between-hand coordination tasks compared to the other two groups.

Conclusion
These results suggest that assessing temporal errors in bimanual coordination tasks, particularly within-hand coordination, may be useful for uncovering pathological characteristics specific to iNPH.
Impact of video instructions and additional hands-on instructions on the dental flossing performance – an observational study
Authors: Jung Katja , Schmidt Sophie-Charlotte , Luka Benedikt , Schlueter Nadine , Ganss Carolina 
Published: November 2024

Abstract
Objectives
This study aimed to evaluate the effectiveness of an instruction-video, with and without additional hands-on instruction, in teaching young adults proper flossing performance.

Materials and Methods
This randomised intervention and observational study included 94 participants, 24 (23; 25) years, receiving an instruction-video with (group 1) or without additional hands-on instruction (group 2). The flossing performance was assessed by videotaping before instruction (T1), after instruction and one week of practice (T2), as well as after two weeks of practice (T3). Parameters of interest were number of interdental spaces reached, adaptation to mesial and distal surfaces, flossing technique, systematic approach and handling combined with self-assessment of flossing skills and time spent, assessed by questionnaires.

Results
Additional hands-on instruction did not lead to a significant improvement in any parameter compared to video-instruction alone. At T1, the participants reached many interdental spaces, but only two managed to floss their entire dentition correctly. After video instruction (T2), the participants reached more interdental spaces (p = 0.039) using a systematic approach and improved adaptation, technique and handling (p < 0.001 each). Parameters improved again at T3, resulting in 42 participants flossing their entire dentition correctly. After instruction participants found flossing less difficult, although they estimated it took more time.

Conclusion
Video-instruction significantly improved flossing performance, whereas hands-on instruction had no additional benefit. This indicates that video-instruction could be an effective and timesaving tool to improve flossing performance.

Clinical relevance
The results emphasize the importance of appropriate teaching-methods in dental prophylaxis and highlight the potential of video-instructions to improve interdental cleaning skills significantly.
The polyhedral geometry of truthful auctions
Authors: Joswig Michael , Klimm Max , Spitz Sylvain 
Published: November 2024

Abstract
The difference set of an outcome in an auction is the set of types that the auction mechanism maps to the outcome. We give a complete characterization of the geometry of the difference sets that can appear for a dominant strategy incentive compatible multi-unit auction showing that they correspond to regular subdivisions of the unit cube. Similarly, we describe the geometry for affine maximizers for n players and m items, showing that they correspond to regular subdivisions of the m-fold product of

$$(n-1)$$

(
n
-
1
)

-dimensional simplices. These observations are then used to construct mechanisms that are robust in the sense that the sets of items allocated to the players change only slightly when the players’ reported types are changed slightly.
Transferable channels for fair micropurchases
Authors: Payeras-Capellà M. Magdalena , Mut Puigserver Macià , Pericàs Gornals Rosa 
Published: November 2024

Abstract
The development of e-commerce applications for small-value transactions introduces significant security and privacy challenges. Micropurchases, that is, commercial operations involving micropayments, offer a practical solution that balances efficiency and security for these transactions. The increasing demand for this payment approach, especially with technologies such as the Internet of Things (IoT), highlights the need for innovative solutions. This paper presents a novel micropurchase protocol utilizing a new type of channels, termed transferable payment channels. The proposed protocol, managed through smart contracts, facilitates fair and equitable exchanges between minimal monetary units (

$$\mu $$

μ

-coins) and desired goods or services, enabling efficient low-value payments. Transferable payment channels enable off-chain transactions, reducing the reliance on on-chain transactions to achieve essential security features and ensure fair exchanges without a centralized intermediary or Trusted Third Party (TTP), commonly employed in traditional payment systems. The protocol outlines the processes for making purchases, handling payments, and incorporating functionalities for the transfer and reuse of payment channels by both customers and merchants. Additionally, it specifies procedures for merchants to redeem earned

$$\mu $$

μ

-coins and for customers to refund unused

$$\mu $$

μ

-coins. This comprehensive set of functions makes the protocol fully functional and highly efficient for micropurchases. By introducing transferable payment channels and minimizing reliance on centralized intermediaries, this work significantly advances the security and efficiency of micropayment systems. The proposed protocol has been implemented and analyzed for both security and performance.
Hyperammonaemic encephalopathy due to non-functioning urea cycle as a complication to gastric bypass surgery
Authors: Kjærgaard Kristoffer , Eriksen Peter Lykke , Nøhr Thomas Kromann , Pedersen Steen Bønløkke , Gravholt Claus Højbjerg , Vilstrup Hendrik , Thomsen Karen Louise 
Published: November 2024

Abstract
Hyperammonaemic encephalopathy in the absence of liver failure is a major diagnostic challenge. A rare cause is as a complication to previous gastric bypass surgery, a condition reported to be associated with high mortality. In this case report, we present the exhaustive diagnostic work-up and clinical reversal of deep and recurrent hyperammonaemic encephalopathy in a patient with previous gastric bypass surgery. As a key finding, the patient exhibited an extreme reduction of the in vivo capacity for urea synthesis, which was reverted by long-standing correction of severe protein and micronutrient malnourishment (Functional Hepatic Nitrogen Clearance; 2.9 to 25.5 L/h). In addition, we observed reduced levels of fasting plasma amino acids (α-amino nitrogen; 2.7 to 3.6 mmol/L) and glucagon (0.3 to 2.6 pmol/L) before clinical improvement, which may contribute to the non-functioning urea synthesis. These observations elucidate the underlying pathophysiology of hyperammonaemia as a complication of gastric bypass and highlight a potential mechanism – non-functioning urea cycle as a result of protein malnourishment and hepatic glucagon resistance.
Exploring the association of adverse drug reactions with medication adherence and quality of life among hypertensive patients: a cross-sectional study
Authors: Insani Widya N. , Wei Li , Abdulah Rizky , Alfian Sofa D. , Ramadhani Nurul A. , Andhika Rizky , Zakiyah Neily , Adesuyan Matthew , Pamela Yunisa , Mustafa Rima , Whittlesea Cate 
Published: November 2024

Abstract
Background
Effective hypertension management requires medication adherence to prevent complications. However, adverse drug reactions (ADRs) can undermine adherence and negatively affect patients’ quality of life. Limited research has explored the association between ADRs, medication adherence, and health-related quality of life (HRQoL) in individuals with hypertension.

Aim
To investigate the association between ADRs, medication adherence, and HRQoL among patients with hypertension.

Method
A cross-sectional study using telephone interviews and medical record reviews was conducted in 11 primary care facilities in Indonesia. The causality of reported ADRs was assessed using the Naranjo algorithm, validated by a panel of experts in pharmacy practice and medication safety. The severity of ADRs was classified using the Hartwig scale. Adherence to antihypertensive drugs was estimated using the Medication Adherence Report Scale-5 (MARS-5). The EuroQoL EQ-5D-5L was used to measure HRQoL. The association between ADRs and medication adherence was assessed using multivariate logistic regression, while the association with HRQoL was evaluated through the Tobit regression model.

Results
A total of 507 patients were included in this study. We found that 20.32% (n = 103) of the patients experienced ADRs, with the most commonly reported ADRs being polyuria and urgency, gastrointestinal symptoms, leg swelling, dizziness/hypotension, palpitations, and dry cough. The majority experienced mild ADRs (n = 75, 72.82%), while 27.18% (n = 28) had reactions of moderate severity. Experiencing ADRs was associated with reduced medication adherence (adjusted odds ratio (OR) 7.15, 95% CI 4.07–12.55) and decreased HRQoL (coefficient: − 0.037).

Conclusion
Patients experiencing ADRs were seven times more likely to be non-adherent to their medication regimen and reported a reduced quality of life compared to those without ADRs, placing them at a higher risk of suboptimal treatment outcomes. This finding highlights the need for additional monitoring and education for patients affected by ADRs, particularly through more frequent clinical and laboratory assessments, timely management of ADRs, and personalized education on the importance of adherence to prevent hypertension-related complications.
An Integrated Framework for Optimal Allocation of Land and Water Resources in an Agricultural Dominant Basin
Authors: Buri Eswar Sai , Keesara Venkata Reddy , Loukika K. N. , Sridhar Venkataramana 
Published: November 2024

Abstract
The water deficit is one of the primary challenges faced by developing countries, stemming from several factors such as limited water resources, population growth, and climate change. Optimal allocation of water resources represents a comprehensive strategy for water resource management, acknowledging the intricate connections between water systems and their repercussions on the environment, society, and economy. It serves as a means of integrating diverse elements of development plans into a cohesive approach for land and water planning and management. In the current study, we undertook the optimal allocation of land and water resources across different sectors for the water years 2016-17, 2017-18, and 2018-19. The study area chosen was the Munneru basin, situated in the lower section of the Krishna River Basin in India. This basin is predominantly agricultural, covering 63.17% of the area, and was selected to validate the proposed framework concept. Within the study area, we identified six distinct water-demanding sectors and calculated their sectoral water demands at a basin level. To assess water availability in the basin, we conducted hydrological modeling employing the Soil and Water Assessment Tool (SWAT). Furthermore, we determined the crop water requirements for various crops using CROPWAT. For the optimal allocation of water resources, we applied the Non-dominated Sorting Genetic Algorithm-II (NSGA – II) optimization model, considering two different objectives that account for social and economic aspects. To identify superior solutions from the Pareto front, we employed the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) and Compromising Programming (CP) methods. Through this methodology, we achieved maximum utilization of water and land resources and maximized returns from the agricultural sector. Following the optimal allocation of land and water, we observed an average annual increase of 3.61% in agricultural sector returns. These outcomes demonstrated a substantial enhancement in the water use efficiency across all pertinent water use sectors. As a result, decision-makers may contemplate the implementation of this framework in large-scale regions, with potential expansion to encompass a national sustainable development strategy at the country level.
Emotions and entrepreneurial finance: Analysis of venture capitalists’ and business angels’ digital footprints on Twitter
Authors: Kaiser Manuel , Kuckertz Andreas 
Published: November 2024

AbstractEmotions are a central concept in previous entrepreneurship research, but this is mainly related to entrepreneurs and their entrepreneurial journey. However, venture capitalists (VCs) and business angels (BAs), two critical investors in the entrepreneurial finance literature, are essential actors in the entrepreneurial process. Still, little is known about investor emotions in this context. Therefore, in this study, we ask how venture capitalists differ from business angels in terms of their expressed emotions. To this end, we use an increasingly familiar research approach by examining the digital footprints of these investors on Twitter. For this purpose, we identify 822 investors from Crunchbase and analyze their 994,969 Tweets with Linguistic Inquiry and Word Count (LIWC) as a text analysis tool. Our results show that venture capitalists display more positive emotions on Twitter than angel investors, meaning that we find an association between VCs and emotional tone. Furthermore, in our post-hoc analysis, we explore further explanations for the differences between VC and BA. In doing so, we show differences in their expressed cognitive processes as well as in their communicated drivers. In both concepts, we find positive associations with the investor type of VC. To conclude this paper, we develop implications for practice and further research based on the results.
Key Adaptive Trait Promotes Contrasting Modes of Diversification in a Bivalve Clade
Authors: Nigro Emily R. , Collins Katie S. , Edie Stewart M. , Crouch Nicholas M. A. , Jablonski David 
Published: November 2024

Abstract
Siphons in bivalves have been postulated as a key adaptive trait, enabling modes of life inaccessible to asiphonate lineages, that afford better protection from predation and dislodgement, thereby enhancing their taxonomic diversification. To test the impact of siphons on diversity, we compared two bivalve clades with similar shell forms and life positions that differ in the presence/absence of this supposed key trait: the asiphonate Archiheterodonta (origin ~ 420 Myr ago) and the siphonate Veneridae (origin ~ 170 Myr ago). We measured three characters relevant to burrowing (shell length, cross-sectional area, and proportional shell volume) in these two groups, finding that siphonate venerids occupy more modes of life than archiheterodonts because they can live at a greater range of distances from the sediment–water interface, with the thinnest shells occurring in the deepest-burrowing groups. Asiphonate taxa have thicker shells, perhaps as a compensatory adaptation in response to the potential for exposure and attack because they are limited to shallower depths of burial. The lack of siphons may have impeded morphologic and taxonomic diversification in archiheterodonts. In contrast, siphons are consistent with a key adaptive trait in the Veneridae, evidently enabling taxonomic diversification into a greater range of morphologies.
Evaluation of corticoresistance in patients with thyroid eye disease and use of rituximab as a second-line treatment
Authors: Pekarova Klara , Schovanek Jan , Dohnal Roman , Radvansky Martin , Karasek David , Karhanova Marta 
Published: November 2024

Abstract

Purpose
High-dose intravenous glucocorticoids are the standard first-line treatment in active, moderate to severe and severe thyroid eye disease (TED). We evaluate the usefulness of clinical activity score (CAS) and thyroid-stimulating immunoglobulin (TSI) as predictors and/or post-treatment markers of corticoresistance in patients with TED and the effect of rituximab in second-line treatment.

Methods
We enrolled 236 patients with an active TED into this retrospective single-tertiary-center cohort study. All patients were initially treated with high-dose systemic glucocorticoids. Rituximab was later administered to 29 of 42 corticoresistant patients.

Results
The CAS of the corticoresistant patients was significantly higher both before (p = 0.0001) and after (p = <0.0001) first-line treatment compared to the corticosensitive group. ROC analysis established the cut-point value as CAS ≥ 2.5 with a sensitivity of 96.3%, specificity of 57.5% and area under the curve of 82.8%. In 22 patients treated with rituximab, CAS gradually decreased to zero values without reactivation during extended follow-up. There was no difference in the TSI of corticosensitive and corticoresistant patients before or after first-line therapy.

Conclusion
CAS ≥ 2, after first-line treatment, could be used as a corticoresistance marker. Corticoresistant patients should be subject to long-term follow-up for early detection of reactivation to reduce the delay to second-line treatment. Rituximab is a well-tolerated choice of second-line treatment and has a long-lasting effect on disease activity. Although TSI is a valuable biomarker of Graves’ disease and TED activity, according to our results, TSI cannot be used as a marker of corticoresistance.
Rental and sale prices of agricultural lands under spatial competition
Authors: Graubner Marten , Hüttel Silke 
Published: November 2024

Abstract
Much of the land economics literature has largely ignored the spatial nature of competition and related differences between farmland rental and sales markets when assessing return rates from farming, the capitalization of agricultural, environmental and energy policy into land values, and climate change impacts. We propose a model for price formation in both markets under a spatial competition framework. We demonstrate that price formation differs, particularly under policy-induced output price shocks.We suggest that using the rent-price ratio as an approximation for expectations in the net returns of farming, based on the net present value model, may produce biased results. In consequence, studies relying on land prices need to control for local land competition, farming structure, and policies.