bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of the Tourniquet on Pain and Function in Total Knee Arthroplasty: a Systematic Review and Meta-Analysis
Authors: Jawhar Ahmed , Skeirek Dania , Stetzelberger Vera , Obertacke Udo 
Published: September 2019

Abstract
Background The use of the tourniquet in total knee arthroplasty is still a subject of controversial discussion. Previous studies mainly focus on parameters like blood loss and operation time. The aim of this systematic review is to evaluate the postoperative outcome involving parameters such as pain intensity, analgesic consumption, knee function and complication rate with and without tourniquet use, to find a recommendation for future application in total knee arthroplasty.
Material and Methods This review is based on the PRISMA Checklists. A systematic research was performed in PubMed using the key words “tourniquet”, “total knee arthroplasty”, “TKA” and “knee endoprosthesis” up to and including January 2018. The initial search revealed 686 Papers which were extracted by the parameters intensity of pain, analgesic consumption, function (range of motion, Hospital for Special Surgery Score, Knee Society Score) and complications (deep vein thrombosis, surgical side infection, pulmonary embolism). The program Review Manager Version 5.3 was used for statistical analysis. A significance level of p < 0,05 was defined.
Results 18 studies were included in this review with 1279 total knee arthroplasties overall (646 with the use of tourniquet and 633 without). The analysis shows a significant lower pain intensity until the fifth postoperative day (p = 0,03) and also after one to three months (p = 0,04) without using the tourniquet. Range of motion is significantly higher in two to three days postoperatively (p < 0,00 001) when the surgery was performed without tourniquet. Knee Society Score shows no difference between the two groups. A deep vein thrombosis appears significantly more often when using a tourniquet (p = 0,04). There was no higher occurrence in pulmonary embolism and surgical side infections.
Conclusion The use of a pneumatic tourniquet in total knee arthroplasty affects especially the early postoperative pain and functional recovery.
Integration aktiv fördern
Authors: Berger Mareike 
Published: September 2019

ZusammenfassungZur Sicherung der Pflege wird angesichts des Personalmangels verstärkt auf
Fachkräfte aus dem Ausland gesetzt. Damit die interkulturelle Zusammenarbeit
gut funktioniert, sollte sie aktiv gefördert werden, rät die
Berufsgenossenschaft für Gesundheitsdienst und Wohlfahrtspflege (BGW).
Stellenpläne und Ausfallkonzepte
Authors: Leydecker Julia , Kutscher Jan 
Published: September 2019

ZusammenfassungWas in Kliniken eigentlich selbstverständlich sein sollte, ist es oft nicht: Das
richtige Ableiten des Stellenplans anhand des Personalbedarfs. Lesen Sie, wie
Sie vorhandene Arbeitsstellen richtig ermitteln und Ihr Ausfallkonzept
systematisieren.
Von Pauschalen und Budgets
Authors: Vaillant Jochen , Wiedmann Oliver 
Published: September 2019

ZusammenfassungDurch die Zusammenführung der Ausbildungen in der Altenpflege, der Gesundheits-
und Kranken- sowie Kinderkrankenpflege ergeben sich auch im Rahmen der
Finanzierung umfangreiche Änderungen. Hier die wichtigsten in
Kürze.
Quantitative intraoperative Messung der Gewebeperfusion von Nierentransplantaten mittels Indocyaningrün-Angiografie
Authors: Ellebrecht David Benjamin , Warns Tilmann , Bürk Conny Georg , Thomaschewski Michael , Keck Tobias , Bausch Dirk 
Published: September 2019

ZusammenfassungDie postoperative Delayed Graft Function (DGF) nach Nierentransplantationen ist definiert als eine Einschränkung der Nierenfunktion nach Nierentransplantation und ist Risikofaktor für ein Transplantatversagen und verkürztes Transplantatüberleben. Ziel dieser Studie war es, die quantitative Perfusion von Nierentransplantaten während der Nierentransplantation zu erfassen und zu untersuchen, ob die gemessene Perfusion Rückschlüsse auf das postoperative Auftreten einer DGF erlaubt. In einem Zeitraum von 1 Jahr wurde bei den Patienten, bei denen ein Einverständnis für die ICG-Perfusionsmessung vorlag, die intraoperative quantitative ICG-Perfusionsmessung mithilfe der Kamera IC-View der Firma Pulsion® durchgeführt. Es erfolgte die Gruppeneinteilung nach postmortaler Spende und Lebendspenden und nach Auftreten bzw. Ausbleiben einer DGF. Intraoperativ erfolgte die Festlegung eines Areals mit starker und geringer ICG-Perfusion. Es wurden die maximale Perfusion, die Anflutzeit der Fluoreszenz und der absolute Anstieg der Fluoreszenz in diesen Arealen dokumentiert. Zusätzlich erfolgte die Berechnung der maximalen Perfusion im Verhältnis zu einem Standardareal. Postoperativ erfolgte die Auswertung durch die Software IC-Calc der Firma Pulsion. Insgesamt konnten 36 Patienten in die Studie eingeschlossen werden. Komplikationen durch die ICG-Applikation traten nicht auf. Bei 10 Patienten, die eine postmortale Nierentransplantatspende erhielten, wurde eine DGF festgestellt (DGF-Gruppe). In der Gruppe der Lebendspende trat eine DGF nicht auf. In den Arealen mit starker ICG-Fluoreszenz fand sich ein signifikanter Unterschied in der maximalen Fluoreszenz zwischen der DGF-Gruppe und Nierenlebendspenden. Die schwach perfundierten Areale wiesen signifikante Unterschiede zwischen der maximalen Perfusion, dem absoluten Anstieg der Perfusion sowie zur Ratio zum Standardareal zwischen DGF und Lebendspenden auf. Ein Unterschied zwischen postmortalen Nierentransplantatspenden ohne DGF und DGF-Gruppe konnte nicht nachgewiesen werden. In dieser Studie zeigte sich, dass sich die quantitative Perfusionsbestimmung von Nierentransplantaten intraoperativ sicher durchführen lässt. Die aktuelle Datenlage deutet eine mögliche zuverlässige Vorhersage der DGF an.
Psychometrische Evaluation der deutschen Version des Semistrukturierten Interviews zur Erfassung der DSM-5 Persönlichkeitsfunktionen (STiP-5.1)
Authors: Zettl Max , Taubner Svenja , Hutsebaut Joost , Volkert Jana 
Published: September 2019

Zusammenfassung
Theoretischer Hintergrund Das alternative Modell für Persönlichkeitsstörungen des DSM-5 führt erstmals ein evidenzbasiertes, dimensionales Konzept für die Diagnostik von Störungen der Persönlichkeit ein. Kriterium A, operationalisiert mit der Level of Personality Functioning Scale, differenziert das Ausmaß von Beeinträchtigungen im Funktionsniveau der Persönlichkeit. Mit dem Semi-Structured Interview for Personality Functioning DSM-5 (STiP-5.1) liegt bereits ein valides, reliables und ökonomisches Interview zur Erfassung von Kriterium A vor. Bisher existiert jedoch keine validierte Form des Interviews in deutscher Sprache. Ziel der vorliegenden Studie ist die psychometrische Evaluation der deutschsprachigen Version des STiP-5.1.
Methodik Die Validität und Reliabilität des STiP-5.1 wurde in einer Stichprobe von gesunden Erwachsenen (n=55) und stationär behandelten Patienten mit der Diagnose einer psychischen Störung (n=55) untersucht. Die Konstruktvalidität wurde über Korrelationen mit Fragebögen zu strukturellen Beeinträchtigungen (IPO-16, OPD-SFK) und maladaptiven Persönlichkeitseigenschaften (SKID-II-PF) überprüft. Die Interrater-Reliabilität wurde in einer Teilstichprobe von Gesunden und Patienten (n=50) untersucht.
Ergebnisse Bezüglich der Validität wurden hohe Korrelationen (r=0,68–0,78) zwischen STiP-5.1-Ratings und konvergenten Selbstberichtfragebögen festgestellt. In der Teilstichprobe zeigte sich eine sehr gute Interrater-Reliabilität (ICC=0,93). Die Dauer der Interviews betrug durchschnittlich 38 Min.
Schlussfolgerungen Mit der deutschen Version des STiP-5.1 liegt ein valides, reliables und ökonomisches Interviewverfahren zur dimensionalen Erfassung von Beeinträchtigungen im Funktionsniveau der Persönlichkeit für Forschung und klinische Praxis vor.
Evaluation of Different Post Lengths’ Effect on Fracture Resistance of a Glass
Fiber Post System
Authors: Adanir Necdet , Belli Sema 
Published: September 2019

ABSTRACTObjectives: The purpose of this in vitro study was to evaluate the influence of different post lengths upon root fracture resistance.Methods: 78 maxillary central teeth with similar dimensions were mounted in acrylic blocks with artificial silicone periodontal ligaments. Combinations of post lengths of 6 mm (shorter than 1/1 clinical crown length), 9 mm (1/1 clinical crown length), and 12 mm (longer than 1/1 clinical crown length) made up 6 different groups consisting of 13 teeth each. The glass fiber posts (Snowpost) were cemented with Super-Bond C&B and Panavia F luting cement. Composite-resin cores were made with Clearfil PhotoCore. The specimens were tested in a universal test machine. The testing machine applied controlled loads to the core, 2 mm from its incisal edge, on the palatal side at an angle 135 degrees to the long axis of the root. The testing machine was set at a crosshead speed of 5mm per minute. All samples were loaded until failure.Results: There was no statistically significant difference between cements (P>.05). Posts shorter than clinical crown length, demonstrated root fracture under significantly lower loading forces (P<.05).Conclusion: Usage of posts shorter than clinical crowns should be avoided to eliminate clinical failure. (Eur J Dent 2008;2:23-28)
Evaluation of Antibacterial Effectiveness of Desensitizers against Oral Bacteria
Authors: Duran Ismet , Sengun Abdulkadir , Hadimli Hasan Huseyin , Ulker Mustafa 
Published: September 2019

ABSTRACTObjectives: Desensitizers contribute to better clinical results by reducing the rate of cervical dentin sensitivity. However, information on their antibacterial effect is limited. This study examined the antibacterial activities of a triclosan containing (Seal & Protect), a benzalconium containing desensitizer (Micro Prime), a fluoride containing prophilaxy paste (Sultan Desensitizer), two fluoride containing varnishes (Cavity Shealth and Ultra EZ), and a dentin bonding primer (All Bond).Methods: The test materials were inserted in the wells of Muller Hinton agar plates inoculated with Streptococcus mutans, Streptococcus salivarious, Staphylococcus aureus, Streptococcus faecalis and Pseudomonas aeruginosa. The diameters of the inhibition zones produced around the materials were measured after 24 h of incubation. The results were analyzed by the Kruskal Wallis one way ANOVA and the Mann-Whitney tests at a significance level of P<.05.Results: Micro Prime Desensitizer containing benzalkonium chloride had the highest antibacterial effectiveness compared to other desensitizers used in this study. In addition, triclosan containing Seal & Protect and acidic components containing All Bond showed very high antibacterial efficacy. On the other hand, fluoride within both varnishes had little antibacterial effectiveness. However a fluoride component in a paste (Sultan Desensitizer) showed very high bactericidal effect.Conclusions: All desensitizers except fluoride varnishes showed various degrees of antibacterial effect against the bacteria tested in this study. If antibacterial effect is also required from the desensitizers’ clinicians should avoid use of varnishes. (Eur J Dent 2008;2:43-47)
Ganglioneuromatous Polyposis of the Colon: a Case Report and a Review of the Literature
Authors: D'Ercole Cristina , Zullo Angelo , Bragazzi Maria Consiglia , Hassan Cesare , Lorenzetti Roberto , Campo Salvatore Maria Antonio 
Published: September 2019

ABSTRACTThis report discusses a case of ganglioneuromatous polyposis of the colon in a woman without any other systemic manifestations. To our knowledge, this is the first report of the few cases of intestinal ganglioneuromatosis described in the literature presenting with abdominal pain and bloody diarrhea as unique clinical signs, with multiple polyps confined in the right side of the transverse colon and in the ascending colon. Of note, the endoscopic feature of such a rare entity - which involves the enteric nervous system - may mimic that of sessile adenomatous polyps which are diagnosed at routine colonoscopy. We emphasized that this condition may be misdiagnosed, and we reviewed the reported cases in the literature. (J Dig Endosc 2011;2(1):18-21)
Obstructive Jaundice: A late presentation of blunt abdominal trauma of extrahepatic biliary tract treated endoscopically
Authors: Patil Mallikarjun , Sheth Keyur A , K. Adarsh C 
Published: September 2019

ABSTRACTCommon bile duct (CBD) injuries from blunt abdominal trauma are rare. The diagnosis is often more difficult with incomplete injuries that result in a delayed presentation. We present a case of CBD injury due to trauma with delayed presentation. Magnetic resonance cholangiopancreatography demonstrated the nature of extrahepatic bile duct and was treated successfully with endoscopic stent placement. (J Dig Endosc 2013;4(1): 16–18)
Mixed polyposis coli: Report of a rare entity with review of literature
Authors: Rao Chalapathi , Rana Surinder Singh , Manrai Manish , Chaudhary Vinita , Nada Ritambhra , Gupta Rajesh , Singh Kartar , Bhasin Deepak Kumar 
Published: September 2019

ABSTRACTColorectal polyps may be detected incidentally on a screening colonoscopy or when they present with symptoms like anemia or gastrointestinal bleeding. Early recognition and prompt management of polyps can cure the primary disease and prevent future risk of malignancies in the patient and provide an opportunity to screen the families in cases of inherited polyposis syndromes. We report a case of rectal bleeding due to colorectal polyps of varying histology. Histology showed hyperplastic polyp, juvenile polyps (JP) with focal dysplasia, adenomatous polyp and villous adenoma with dysplasia. He underwent total proctocolectomy with ileal pouch anal anastomosis (J-pouch) (TP-IPAA). Mixed polyposis syndrome is a rare entity. (J Dig Endosc 2013;4(2):39-41)
Gross motor teaching in preschool education: where, what and how do Singapore educators teach? (Enseñanza de la motricidad gruesa en educación infantil: ¿dónde, qué y cómo enseñan las maestras en Singapur?)
Authors: Bautista Alfredo , Moreno-Núñez Ana , Vijayakumar Poorani , Quek Erin , Bull Rebecca 
Published: September 2019

Fostering the development of gross motor (GM) skills is important in itself and beneficial for the holistic development of children. While early childhood curriculum frameworks for GM teaching have been recently articulated, there is limited research on actual pedagogical practices. This study explored GM teaching practices in Singapore Kindergarten 1 classrooms (4–5 years), focusing on where (indoors vs outdoors), what (types of GM skills) and how (teaching strategies and opportunities for practice) preschool educators teach. The study is part of a longitudinal project in which 108 Kindergarten 1 classrooms were observed and videotaped during a full ‘typical day’ (3–4 hours). GM teaching was observed to occur predominantly indoors. Non-locomotor skills were the most frequently taught to children, followed by locomotor and manipulative skills. Many educators were observed using explicit teaching strategies before and during GM activities, with low involvement after activities had been completed. While GM teaching was predominantly teacher-led, opportunities for unguided practice and play were more frequent outdoors. We conclude that Singapore preschool educators need support to better enact the guidelines of the GM curriculum framework. The study enriches the thin classroom-based international literature on GM education.
ChIPseqSpikeInFree: a ChIP-seq normalization approach to reveal global changes in histone modifications without spike-in
Authors: Jin Hongjian , Kasper Lawryn H , Larson Jon D , Wu Gang , Baker Suzanne J , Zhang Jinghui , Fan Yiping 
Published: September 2019

Abstract

Motivation
The traditional reads per million normalization method is inappropriate for the evaluation of ChIP-seq data when treatments or mutations have global effects. Changes in global levels of histone modifications can be detected with exogenous reference spike-in controls. However, most ChIP-seq studies overlook the normalization that must be corrected with spike-in. A method that retrospectively renormalizes datasets without spike-in is lacking.

Results
ChIPseqSpikeInFree is a novel ChIP-seq normalization method to effectively determine scaling factors for samples across various conditions and treatments, which does not rely on exogenous spike-in chromatin or peak detection to reveal global changes in histone modification occupancy. Application of ChIPseqSpikeInFree on five datasets demonstrates that this in silico approach reveals a similar magnitude of global changes as the spike-in method does.

Availability and implementation
St. Jude Cloud (https://pecan.stjude.cloud/permalink/spikefree) and St. Jude Github ( https://github.com/stjude/ChIPseqSpikeInFree).

Supplementary information
Supplementary data are available at Bioinformatics online.
DeepCleave: a deep learning predictor for caspase and matrix metalloprotease substrates and cleavage sites
Authors: Li Fuyi , Chen Jinxiang , Leier André , Marquez-Lago Tatiana , Liu Quanzhong , Wang Yanze , Revote Jerico , Smith A Ian , Akutsu Tatsuya , Webb Geoffrey I , Kurgan Lukasz , Song Jiangning 
Published: September 2019

Abstract

Motivation
Proteases are enzymes that cleave target substrate proteins by catalyzing the hydrolysis of peptide bonds between specific amino acids. While the functional proteolysis regulated by proteases plays a central role in the ‘life and death’ cellular processes, many of the corresponding substrates and their cleavage sites were not found yet. Availability of accurate predictors of the substrates and cleavage sites would facilitate understanding of proteases’ functions and physiological roles. Deep learning is a promising approach for the development of accurate predictors of substrate cleavage events.

Results
We propose DeepCleave, the first deep learning-based predictor of protease-specific substrates and cleavage sites. DeepCleave uses protein substrate sequence data as input and employs convolutional neural networks with transfer learning to train accurate predictive models. High predictive performance of our models stems from the use of high-quality cleavage site features extracted from the substrate sequences through the deep learning process, and the application of transfer learning, multiple kernels and attention layer in the design of the deep network. Empirical tests against several related state-of-the-art methods demonstrate that DeepCleave outperforms these methods in predicting caspase and matrix metalloprotease substrate-cleavage sites.

Availability and implementation
The DeepCleave webserver and source code are freely available at http://deepcleave.erc.monash.edu/.

Supplementary information
Supplementary data are available at Bioinformatics online.
phylogenize: correcting for phylogeny reveals genes associated with microbial distributions
Authors: Bradley Patrick H , Pollard Katherine S 
Published: September 2019

Abstract

Summary
Phylogenetic comparative methods are powerful but presently under-utilized ways to identify microbial genes underlying differences in community composition. These methods help to identify functionally important genes because they test for associations beyond those expected when related microbes occupy similar environments. We present phylogenize, a pipeline with web, QIIME 2 and R interfaces that allows researchers to perform phylogenetic regression on 16S amplicon and shotgun sequencing data and to visualize results. phylogenize applies broadly to both host-associated and environmental microbiomes. Using Human Microbiome Project and Earth Microbiome Project data, we show that phylogenize draws similar conclusions from 16S versus shotgun sequencing and reveals both known and candidate pathways associated with host colonization.

Availability and implementation
phylogenize is available at https://phylogenize.org and https://bitbucket.org/pbradz/phylogenize.

Supplementary information
Supplementary data are available at Bioinformatics online.
L1EM: a tool for accurate locus specific LINE-1 RNA quantification
Authors: McKerrow Wilson , Fenyö David 
Published: September 2019

AbstractMotivationLINE-1 elements are retrotransposons that are capable of copying their sequence to new genomic loci. LINE-1 derepression is associated with a number of disease states, and has the potential to cause significant cellular damage. Because LINE-1 elements are repetitive, it is difficult to quantify LINE-1 RNA at specific loci and to separate transcripts with protein coding capability from other sources of LINE-1 RNA.ResultsWe provide a tool, L1EM that uses the expectation maximization algorithm to quantify LINE-1 RNA at each genomic locus, separating transcripts that are capable of generating retrotransposition from those that are not. We show the accuracy of L1EM on simulated data and against long read sequencing from HEK cells.Availability and implementationL1EM is written in python. The source code along with the necessary annotations are available at https://github.com/FenyoLab/L1EM and distributed under GPLv3.Supplementary informationSupplementary data are available at Bioinformatics online.
T-lex3: an accurate tool to genotype and estimate population frequencies of transposable elements using the latest short-read whole genome sequencing data
Authors: Bogaerts-Márquez María , Barrón Maite G , Fiston-Lavier Anna-Sophie , Vendrell-Mir Pol , Castanera Raúl , Casacuberta Josep M , González Josefa 
Published: September 2019

Abstract

Motivation
Transposable elements (TEs) constitute a significant proportion of the majority of genomes sequenced to date. TEs are responsible for a considerable fraction of the genetic variation within and among species. Accurate genotyping of TEs in genomes is therefore crucial for a complete identification of the genetic differences among individuals, populations and species.

Results
In this work, we present a new version of T-lex, a computational pipeline that accurately genotypes and estimates the population frequencies of reference TE insertions using short-read high-throughput sequencing data. In this new version, we have re-designed the T-lex algorithm to integrate the BWA-MEM short-read aligner, which is one of the most accurate short-read mappers and can be launched on longer short-reads (e.g. reads &gt;150 bp). We have added new filtering steps to increase the accuracy of the genotyping, and new parameters that allow the user to control both the minimum and maximum number of reads, and the minimum number of strains to genotype a TE insertion. We also showed for the first time that T-lex3 provides accurate TE calls in a plant genome.

Availability and implementation
To test the accuracy of T-lex3, we called 1630 individual TE insertions in Drosophila melanogaster, 1600 individual TE insertions in humans, and 3067 individual TE insertions in the rice genome. We showed that this new version of T-lex is a broadly applicable and accurate tool for genotyping and estimating TE frequencies in organisms with different genome sizes and different TE contents. T-lex3 is available at Github: https://github.com/GonzalezLab/T-lex3.

Supplementary information
Supplementary data are available at Bioinformatics online.