bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dendritic cell mineralocorticoid receptor controls blood pressure by regulating T helper 17 differentiation: role of the Plcβ1/4–Stat5–NF-κB pathway
Authors: Wang Yong-Li , Zhu Hong , Pan Yi-Tong , Shang Da , Du Lin-Juan , Bai Lan , Zhu Shi-Wei , Lin Wen-Zhen , Zhang Xing-Yu , Lu Hai-Xia , Bi Chao , Liu Yuan , Liu Yan , Xiao Hui , Qian You-Cun , Zhou Bin , Li Ruo-Gu , Duan Sheng-Zhong 
Published: November 2024

Abstract

Background and Aims
Dendritic cells (DCs) are closely related to blood pressure (BP) regulation. Mineralocorticoid receptor (MR) is an important drug target for antihypertensive treatment. However, the role of DC MR in the pathogenesis of hypertension has not been fully elucidated. This study aimed to determine the role of DC MR in BP regulation and to explore the mechanism.

Methods
Renal biopsy and peripheral blood samples were collected from hypertensive patients (HTN) for immunostaining and flow cytometry. Dendritic cell MR knockout (DCMRKO) mice, DC MR overexpressing (DCMROV) mice, DCMROV/IL-17A knockout (DCMROV/IL-17AKO) mice and finerenone-treated C57BL/6 mice were infused with angiotensin II (Ang II) to establish hypertensive models. Western blotting, chromatin immunoprecipitation, co-immunoprecipitation, and in vivo DC depletion or adoptive transfer were used to delineate the functional importance of DC MR in hypertension development.

Results
Mineralocorticoid receptor antagonists (spironolactone and finerenone) suppressed DC aggregation and activation, as well as hypertension in HTN and mice. Compared with littermate control (LC) mice, dendritic cell MR knockout mice had strikingly decreased BPs and attenuated target organ damage after Ang II infusion. Flow cytometry showed that DC MR deficiency mitigated Ang II-induced DC activation and T helper 17 (Th17) cell differentiation. RNA sequencing revealed that MR-deficient DCs had elevated expression of Plcβ1 and Plcβ4, knockdown of which reversed the inhibitory effect of MR deficiency on DC activation and Th17 differentiation. Adoptive transfer of MR-deficient DCs protected Ang II-induced hypertension, whereas knockdown of Plcβ1/4 eliminated the protective effects. At the molecular level, MR negatively regulated Plcβ1/4, which recruited SHP-1 to inactivate of Stat5 activity, resulting in enhanced NF-κB activation and Th17 polarization. Furthermore, DCMROV mice manifested more elevated BPs and target organ damage than control mice after Ang II infusion, and these differences were abolished in DCMROV/IL-17AKO mice. Finally, MR antagonists decreased the aggregation of Th17 in HTN and mice.

Conclusions
Dendritic cell MR plays important roles in the pathogenesis of hypertension by regulating Th17 through Plcβ1/4–Stat5–NF-κB signalling, and blockade of DC MR is beneficial for treating hypertension.
Chromosome-scale genome assembly of Apocynum pictum, a drought-tolerant medicinal plant from the Tarim Basin
Authors: Xie Wenlong , Bai Baowei , Wang Yanqin 
Published: November 2024

Abstract
Apocynum pictum Schrenk is a semishrub of the Apocynaceae family with a wide distribution throughout the Tarim Basin that holds significant ecological, medicinal, and economic values. Here, we report the assembly of its chromosome-level reference genome using Nanopore long-read, Illumina HiSeq paired-end, and high-throughput chromosome conformation capture sequencing. The final assembly is 225.32 Mb in length with a scaffold N50 of 19.64 Mb. It contains 23,147 protein-coding genes across 11 chromosomes, 21,148 of which (91.36%) have protein functional annotations. Comparative genomics analysis revealed that A. pictum diverged from the closely related species Apocynum venetum approximately 2.2 million years ago and has not undergone additional polyploidizations after the core eudicot WGT-γ event. Karyotype evolution analysis was used to characterize interchromosomal rearrangements in representative Apocynaceae species and revealed that several A. pictum chromosomes were derived entirely from single chromosomes of the ancestral eudicot karyotype. Finally, we identified 50 members of the well-known stress-responsive WRKY transcription factor family and used transcriptomic data to document changes in their expression at 2 stages of drought stress, identifying a number of promising candidate genes. Overall, this study provides high-quality genomic resources for evolutionary and comparative genomics of the Apocynaceae, as well as initial molecular insights into the drought adaptation of this valuable desert plant.
The Association between Psychotropic Medication Use and Gait and Mobility Impairment in Community-Dwelling Older People. Data from The Irish Longitudinal Study on Ageing (TILDA)
Authors: O’ Donnell Desmond , Moriarty Frank , Lavan Amanda , Kenny Rose Anne , Briggs Robert 
Published: November 2024

Abstract

Background
Little work to date has quantified the effect of psychotropic medications (antidepressants, benzodiazepines, ‘Z’ drugs, antipsychotics, anticholinergics) on mobility and gait in later life. The aim of this study is to examine the relationship between these medications and mobility/gait parameters in a large cohort of community-dwelling older people.

Methods
Participants were included if they were ≥60 years at TILDA Wave 1 and underwent gait and mobility assessment (Gaitrite system), with follow-up at Wave 3 (4 years). Medication lists were examined for psychotropic medications. Regression models assessed the relationship between psychotropic medications and mobility, using the following parameters: Timed Up and Go (TUG), gait speed, step length / width, double support phase. Multilevel modelling assessed trajectories of mobility/gait variables over time by psychotropic use.

Results
Of 2620 patients, 12% were prescribed ≥1 psychotropic medication, 3% prescribed ≥2 psychotropics. Cross-sectionally, psychotropic medication was independently associated with prolonged TUG (β=0.50 (95% CI 0.27–0.73); p&lt;0.001), slower gait speed (β=-5.65 (95% CI -7.92 - -3.38); p&lt;0.001), shorter step length (β=-2.03 (95% CI -2.93 - -1.42); p&lt;0.001) and increased double support phase (β=0.47 (95% CI 0.19-0.75); p=0.001).
Longitudinally, psychotropic use was independently associated with transition to abnormal TUG (OR 2.68 (95% CI 1.55–4.64), p&lt;0.001), while using ≥2 psychotropics was associated with transition to slower gait speed (OR 2.59 (95% CI 1.01–6.68); p=0.048).

Conclusions
Psychotropic use was associated with significantly poorer mobility and gait performance, both cross-sectionally and longitudinally. It is imperative that psychotropic medication use is reviewed as part of comprehensive geriatric assessment.
A mathematical model for potash supply chain management with a strategic logistics perspective
Authors: Shbool Mohammad A , Al-Bazi Ammar , Albashabsheh Nibal T 
Published: November 2024

Abstract
Accepted by: M. Zied Babai
This paper introduces a novel Integer Linear Programming model designed to enhance the efficiency and sustainability of the potash supply chain, a crucial element supporting global agriculture. The developed mathematical optimization model focuses on fleet selection (private/outsource) and incorporates the concept of ‘inter-warehouse collaboration’, which addresses key logistics considerations. Integrating mining, processing, storage and transportation, the model encompasses decision variables like extracted carnallite amount, production, storage levels and shipped potash amount. Illustrated through a case study on the Arab Potash Company in Jordan, the results showcase the model’s proficiency in meeting local and international market demands. The model ensures resilient and sustainable supply chain performance by emphasizing logistics optimization, particularly in fleet selection. The study attains the highest ‘warehouse-to-warehouse’ support for Standard and Granular potash types in the international demand scenario, contributing to efficient production planning and fleet management. In conclusion, the presented mathematical model is a valuable tool for potash industry stakeholders, offering insights for strategic decision-makers involved in production planning and fleet management.
DHH and L2 college students’ knowledge of English resultatives and depictives
Authors: Kelly Ronald R , Berent Gerald P , Finton Erin , Schueler-Choukairi Tanya , Van Horn Stanley , Chen Zhong , Persky Kimberly , Rizzo Susan Post , Schmitz Kathryn L 
Published: November 2024

Abstract
College-level deaf and hard-of-hearing (DHH) students and hearing students of English as a Second Language (L2) along with hearing native speakers (NS) of English were assessed in their knowledge of English resultative and depictive sentences. In “Kevin wiped the table clean,” the resultative phrase “clean” indicates that the table became clean as a result of Kevin wiping it. In “Megan drove the car drunk,” the depictive phrase “drunk” describes Megan’s state throughout the entire event of driving. Findings of a sentence-acceptability rating scale task revealed higher performance by the NS group compared to the DHH and L2 groups, whose near-equivalent performance improved with increasing overall English proficiency. Participants exhibited higher performance on active, passive, and unaccusative resultative sentences than on ungrammatical unergative resultatives and higher performance on grammatical than ungrammatical depictive sentence types. These findings contribute new insights into the comparative study of English acquisition by DHH and L2 learners.
Clinical and surgical factors influencing screw breakage during hardware removal following periacetabular osteotomy
Authors: Crowley Brian P , Helm James M , Stocks Omar G , Aboulafia Alexis H , Siahaan Jacob J , Mansour Alfred A 
Published: November 2024

Abstract
Periacetabular osteotomy (PAO) is a procedure used to treat patients with hip dysplasia. Current literature reports symptomatic hardware removal (HWR) rates of 13.6% following PAO. No reports have examined the incidence of or factors relating to screw breakage during HWR. This study reports the incidence of screw breakage in patients undergoing HWR following PAO and examines the associated clinical and surgical factors. Patients who underwent PAO by a single surgeon from 2012 to 2022 were retrospectively reviewed. Demographic, surgical, and implant information was collected. Constructs were stratified by number (three-screw and four-screw) and type (3.5 mm only, 4.5 mm only, and mixed). Incidence rates of HWR and screw breakage were calculated. Three hundred and two hips from 254 patients undergoing PAO were included. Seventy-one hips from 58 patients underwent HWR (23.5%). Eighteen of 259 screws (6.9%) were broken upon removal in 10/71 hips (14.1%). Significantly more 3.5-mm screws were removed (24.7% vs 21.2%; P = .05) and broken than 4.5-mm screws (10.5% vs 3.8%; P = .04). Time to removal was significantly longer in broken screws (16.8 ± 12.7 months vs 33 ± 18.2 months, P &lt; .001). The use of 3.5-mm screws and increased time from implantation to removal are associated with higher rates of screw breakage during HWR following PAO. The use of 4.5-mm screws and earlier time to removal (less than 12 months) both decrease the probability of breakage.
The Ongwen Judgments
Authors: Taku Charles A , Lyons Beth S 
Published: November 2024

Abstract
The Ongwen trial and appeal judgments are an affront to child soldiers everywhere and to international criminal justice. The judgments fail to treat Mr Dominic Ongwen as an individual within his own social context, in which culture and race are significant factors. The Chambers invisibilized the victimization of Mr Ongwen within the cruel and ruthless conditions of the Lord’s Resistance Army (LRA) as a child and young adult. Seeking justice for Mr Ongwen and ensuring he had a fair trial has been a Sisyphean struggle for the defence counsel, who have tried to humanize the lived experience of our client within the courtroom of the Hague. The Chambers acknowledged the brutality and bestiality of the LRA, led by Joseph Kony, yet created an ‘Ongwen Exception’ that dehumanized him as detached from the Court’s previous rulings on the long-term social and psychological effects of being forcibly recruited as a child soldier. In these observations, the Defence discusses Mr Ongwen’s social context, emphasizing the importance of culture and race within it, and the dangers of the Chambers’ rote and narrow interpretation of Article 26 ICC Statute, which underlies Mr Ongwen’s convictions.
Enhancing capacity for primary care research in cancer survivorship: National Cancer Institute meeting report
Authors: Hudson Shawna V , Mollica Michelle A , Reed Crystal , Hahn Erin E , O’Malley Denalee M , Radhakrishnan Archana , Klemp Jennifer , Tonorezos Emily 
Published: November 2024

Abstract
Many components of long-term cancer follow-up and survivorship care are managed in the primary care context. Given the important role that primary care has in survivorship care, it is critical to ensure that teams in these settings are prepared to address long-term needs. Evidence-based strategies to deliver survivorship care in primary care settings in the United States remain limited. The National Cancer Institute Office of Cancer Survivorship conducted a day-long virtual event, Enhancing Capacity for Primary Care Research in Cancer Survivorship: A Workshop for Action, on February 28, 2024, to discuss research needs addressing the intersection between primary care and cancer survivorship. Topics discussed to advance this area of research included system-level interventions, methods and measurement, and mentorship and research team building, especially for early career researchers. The purpose of this report is to provide a summary of the key findings. Gaps and opportunities include (1) health systems–level research that investigates primary care practice–level capacity, (2) identification and characterization of the targeted cancer survivor populations for primary care research, (3) leveraging electronic medical records to track relevant patient outcomes throughout survivorship, and (4) development and creation of communities of practice to support and build research capacity. Team science approaches were identified as a core strategy to advance survivorship research. The meeting closed with a reflection and call to action focused on building collaborations that span different research areas, disciplines, and organizations and building a broad network of a primary care practice–focused research.
JWST lensed quasar dark matter survey – II. Strongest gravitational lensing limit on the dark matter free streaming length to date
Authors: Keeley Ryan E , Nierenberg A M , Gilman D , Gannon C , Birrer S , Treu T , Benson A J , Du X , Abazajian K N , Anguita T , Bennert V N , Djorgovski S G , Gupta K K , Hoenig S F , Kusenko A , Lemon C , Malkan M , Motta V , Moustakas L A , Oh Maverick S H , Sluse D , Stern D , Wechsler R H 
Published: November 2024

ABSTRACT
This is the second in a series of papers in which we use JWST Mid Infrared Instrument multiband imaging to measure the warm dust emission in a sample of 31 multiply imaged quasars, to be used as a probe of the particle nature of dark matter. We present measurements of the relative magnifications of the strongly lensed warm dust emission in a sample of nine systems. The warm dust region is compact and sensitive to perturbations by populations of haloes down to masses $\sim 10^6$ M$_{\odot }$. Using these warm dust flux-ratio measurements in combination with five previous narrow-line flux-ratio measurements, we constrain the halo mass function. In our model, we allow for complex deflector macromodels with flexible third- and fourth-order multipole deviations from ellipticity, and we introduce an improved model of the tidal evolution of subhaloes. We constrain a WDM model and find an upper limit on the half-mode mass of $10^{7.6}\, {\rm M}_\odot$ at posterior odds of 10:1. This corresponds to a lower limit on a thermally produced dark matter particle mass of 6.1 keV. This is the strongest gravitational lensing constraint to date, and comparable to those from independent probes such as the Ly $\alpha$ forest and Milky Way satellite galaxies.
Cold Gas Subgrid Model (CGSM): a two-fluid framework for modelling unresolved cold gas in galaxy simulations
Authors: Butsky Iryna S , Hummels Cameron B , Hopkins Philip F , Quinn Thomas R , Werk Jessica K 
Published: November 2024

ABSTRACT
The cold ($\sim 10^{4}\, {\rm K}$) component of the circumgalactic medium (CGM) accounts for a significant fraction of all galactic baryons. However, using current galaxy-scale simulations to determine the origin and evolution of cold CGM gas poses a significant challenge, since it is computationally infeasible to directly simulate a galactic halo alongside the sub-pc scales that are crucial for understanding the interactions between cold CGM gas and the surrounding ‘hot’ medium. In this work, we introduce a new approach: the Cold Gas Subgrid Model (CGSM), which models unresolved cold gas as a second fluid in addition to the standard ‘normal’ gas fluid. The CGSM tracks the total mass density and bulk momentum of unresolved cold gas, deriving the properties of its unresolved cloudlets from the resolved gas phase. The interactions between the subgrid cold fluid and the resolved fluid are modelled by prescriptions from high-resolution simulations of ‘cloud crushing’ and thermal instability. Through a series of idealized tests, we demonstrate the CGSM’s ability to overcome the resolution limitations of traditional hydrodynamics simulations, successfully capturing the correct cold gas mass, its spatial distribution, and the time-scales for cloud destruction and growth. We discuss the implications of using this model in cosmological simulations to more accurately represent the microphysics that govern the galactic baryon cycle.
The VST ATLAS Quasar Survey – II. Halo mass profiles of galaxies, LRGs and galaxy clusters via quasar and CMB lensing
Authors: Eltvedt Alice M , Shanks T , Metcalfe N , Ansarinejad B , Barrientos L F , Murphy D N A , Alexander D M 
Published: November 2024

ABSTRACT
We cross-correlate a low-contamination subset of the VST ATLAS $g\lt 22.5$ quasar catalogue with $g\lt 21.5$ galaxy clusters, $r\lt 21$ galaxies and $r\lt 19.5$ luminous red galaxies (LRGs) to probe their halo mass profiles via quasar magnification bias caused by weak lensing. In the case of galaxy clusters, we find that at small scales their mass profiles are well fitted by Navarro, Frenk, and White models with masses within the expected range. For the galaxies, we find consistency with previous Sloan Digital Sky Survey-based results for the galaxy–quasar cross-correlation and the galaxy auto-correlation functions. Disagreement as to whether the cross-correlation results are in tension with $\Lambda$cold dark matter appears due to different assumptions as to whether galaxies trace mass. We conclude that halo occupation distribution (HOD) models fit the galaxy–quasar lensing results better than models where galaxies trace the mass. We further test the cluster and galaxy HOD models in the 2-halo range using the Planck cosmic microwave background (CMB) lensing map, finding that the cross-correlation with both the poorest clusters and the galaxies may be marginally overpredicted by the above HOD models. Finally, we measure the magnification bias of LRGs using both quasar and CMB lensing and find that the observed quasar lensing amplitude may be ${\approx} 2\times$ too high and, on larger scales, the CMB lensing amplitude may be too low to be explained by a standard LRG HOD model.
Instability and warping in vertically oscillating accretion discs
Authors: Held Loren E , Ogilvie Gordon I 
Published: November 2024

ABSTRACT
Many accretion discs have been found to be distorted: either warped due to a misalignment in the system, or non-circular as a result of orbital eccentricity or tidal deformation by a binary companion. Warped, eccentric, and tidally distorted discs are not in vertical hydrostatic equilibrium, and thus exhibit vertical oscillations in the direction perpendicular to the disc, a phenomenon that is absent in circular and flat discs. In extreme cases, this vertical motion is manifested as a vertical ‘bouncing’ of the gas, potentially leading to shocks and heating, as observed in recent global numerical simulations. In this paper, we isolate the mechanics of vertical disc oscillations by means of quasi-2D and fully 3D hydrodynamic local (shearing-box) models. To determine the numerical and physical dissipation mechanisms at work during an oscillation we start by investigating unforced oscillations, examining the effect of initial oscillation amplitude, as well as resolution, boundary conditions, and vertical box size on the dissipation and energetics of the oscillations. We then drive the oscillations by introducing a time-dependent gravitational potential. A key result is that even a purely vertically oscillating disc is (parametrically) unstable to developing inertial waves, as we confirm through a linear stability analysis. The most important of these has the character of a bending wave, whose radial wavelength depends on the frequency of the vertical oscillation. The nonlinear phase of the instability exhibits shocks, which dampen the oscillations, although energy can also flow from the bending wave back to the vertical oscillation.
GCM and gcType in 2024: comprehensive resources for microbial strains and genomic data
Authors: Fan Guomei , Sun Qinglan , Sun Yan , Liu Dongmei , Li Shiwen , Li Min , Chen Qi , Wang Fang , Moriya Ohkuma , Itoh Takashi , Kawasaki Hiroko , Yu Yajing , Cai Man , Kim Song-Gun , Lee Jung-Sook , Ma Juncai , Wu Linhuan 
Published: November 2024

Abstract
Microbial culture collections play a crucial role in the collection, maintenance, and distribution of quality-assured living microbial strains, along with their associated phenotypic and omics data. To enhance the find-able, accessible, interoperable, and re-usable (FAIR) data utilization of microbial resources, the World Data Center for Microorganisms (WDCM) has developed the Global Catalogue of Microorganisms (GCM) and the Global Catalogue of Type Strains (gcType). These platforms provide interactive interfaces for cataloging the holdings of collections, along with detailed annotations of type strain genomes and curated metadata, including ecosystems, growth conditions, and collection locations. The system maximizes the scientific impact of microbial resources and culture collections through an integrated data mining tool that links strain- and species-related information from various public resources. Currently, the GCM and gcType include 574 422 strains from 154 culture collections across 51 countries and regions, along with 25 980 genomes from type species. Additionally, 2 702 655 articles and 103 337 patents are integrated with these microbial resources. The system supports microbial taxonomic research and provides evidence for implementing the Nagoya Protocol in the field of microbial resources and their digital sequence information (DSI). Access is freely available at gcm.wdcm.org and gctype.wdcm.org.