bluuebunny/crossref_metadata_2025_split huggingface dataset:
A catalog of spectroscopic binary candidate stars derived from a comparison of Gaia DR2 with other radial velocity catalogs
Authors: Jack Dennis 
Published: June 2019

AbstractUsing the recently published Gaia second data release that includes measurements of the mean radial velocity of about 7.2 million stars, we performed a systematic comparison with other existing radial velocity catalogs to search for variations in the radial velocity measurements, with the goal that detected differences may indicate that these stars are possibly spectroscopic binary stars with only one visible component (SB1). We present a catalog of spectroscopic binary candidate stars containing 35,246 stars, compiled to encourage follow‐up observations obtaining spectra at different epochs of orbits of these stars to verify their binarity and to study these systems using radial velocity curves. Comparing the Gaia DR2 database with the K‐M dwarf catalog, we found 16 stars that show radial velocity variations. In a comparison with the Pulkovo radial velocity catalog of Hipparcos stars, we identified a total of 539 SB1 candidate stars. In the largest radial velocity catalog available, the radial velocity experiment (RAVE) catalog, we found a total of 34,691 stars that show radial velocity variations when compared to the Gaia DR2 data.
Enhancing social sustainability at a business level: Organizational attractiveness is higher when organizations show responsibility towards employees
Authors: Carballo‐Penela Adolfo 
Published: June 2019

AbstractSelecting employees considering their fit with organizations' values for sustainable development can be an effective way of enhancing sustainable development at a business level. Employers' commitment with sustainable development will be stronger if sustainable development initiatives help them to achieve organizational objectives as attracting talented employees.This study discusses if recruitment messages including information on the social dimension of sustainable development are valued by prospective employees. In particular, we are interested in finding out if five actions showing employer responsibility towards employees influence prospective job applicants' perceptions of organizational attraction.Results from a policy‐capturing study that combines nomothetic and ideographic designs confirm that organizational attractiveness is higher when organizations show responsibility towards employees. Our findings also show the relevance of each of the studied actions to explain organizational attractiveness and differences among participants' perceptions. Results from ideographic analysis underline differences on attractiveness perceptions among participants.
The immunostimulatory effects and pro‐apoptotic activity of rhCNB against Lewis lung cancer is mediated by Toll‐like receptor 4
Authors: Yang Jinju , Zhang Hongwei , Zhu Ziwei , Gao Yadan , Xiang Benqiong , Wei Qun 
Published: June 2019

AbstractBackgroundRecombinant human calcineurin B subunit (rhCNB) has been shown to be an immune‐stimulatory protein promoting cytokine production and inducing phenotypic maturation of Dendritic cells (DCs). In vivo, it has good antitumor efficacy, and has potential as an antitumor drug. Exogenous rhCNB was found to be internalized into tumor cells via the Toll‐like receptor 4 (TLR4) complex, but it was not known whether its immuno‐modulatory and antitumor functions involved entry by this same route.MethodsThe production and secretion of the cytokines and chemokines in innate immune cells induced by rhCNB were determined by ELISA, and the expression of CD40, CD80, CD86, and MHCII was analyzed by FACs. Experimental Lewis lung cancer (LLC) model was prepared in C57 BL/6 wild‐type (WT) mice, TLR4−/− mice or their littermates by the inoculation of LLCs in their right armpit, and then administrated daily intraperitoneal injections (0.2 mL) of normal saline, rhCNB 20 mg/kg, and rhCNB 40 mg/kg, respectively.ResultsRecombinant human calcineurin B subunit promoted the production of antitumor cytokines by innate immune cells, and culture supernatants of rhCNB‐stimulated immune cells induced apoptosis of LLCs. In addition, rhCNB up‐regulated CD40, CD80, CD86, and MHCII expression in macrophages and DCs in TLR4+ cells but failed to do so in TLR4 deficient cells. rhCNB also induced the formation of CD4+ and CD8+T cells in splenocytes from WT mice, but not from TLR4‐deficient littermates. Intraperitoneal administration of WT C57BL/6 mice with rhCNB resulted in a 50% reduction in LLC tumor growth, but failed to inhibit tumor growth in TLR4−/− littermates.ConclusionsThe in vivo antitumor and immunomodulatory effects of rhCNB are mediated by the TLR4. This conclusion is important for the further understanding and development of rhCNB as an antitumor drug.
Metronomic combination chemotherapy using everolimus and etoposide for the treatment of non‐Hodgkin lymphoma
Authors: Wu Ke , Sun Xiao‐Qing , Wang Cai‐Qin , Gao Tian‐Xiao , Sun Peng , Wang Yu , Jiang Wen‐Qi , Li Zhi‐Ming , Huang Jia‐Jia 
Published: June 2019

AbstractPatients with Non‐Hodgkin lymphoma (NHL) treated by conventional chemotherapeutic drugs usually require a long recovery period. However, metronomic combination chemotherapy (MCC) enhances therapeutic efficacy and decreases side effects in the treatment of NHL. In this study, we tested and compared the effects of metronomic chemotherapy (MC) using podophyllotoxin derivative etoposide (VP‐16) alone and that of MCC using both VP‐16 and everolimus (RAD001) in the treatment of NHL. Two types of NHL cells, OCI‐LY‐10 and SU‐DHL‐6, were employed for the experiments. Cell proliferation, apoptosis, and cell senescence were measured to test the effects of drugs in each experiment. In addition, the influences of MC and MCC on the cell cycle and autophagy pathway were evaluated to study the functional mechanisms behind their effects. Finally, we conducted analyses of the growth inhibitory effect and synergistic activity for different MCC. The results showed that MC using low‐dose VP‐16 alone demonstrated strong treatment effects in terms of inducing apoptosis, cell senescence, and reducing tumor cell proliferation, and this treatment also led to changes of the cell cycle. Compared with MC, MCC using VP‐16 and RAD001 together demonstrated even stronger treatment effects, with both the cell cycle and autophagy‐related proteins being affected. Considering the synergistic activity, our results showed the MCC of VP‐16 48 hours + RAD001 24 hours is the optimal method for treating NHL.
Effects of somatic alterations at pathway level are more mechanism‐explanatory and clinically applicable to quantity of liver metastases of colorectal cancer
Authors: Zhang Zhong‐guo , Ma Fei , Zhao Shuang , Yang Xiaoyu , Liu Fang , Xue Chenghai , Liu Liren , Gu Jin , Piao Haozhe 
Published: June 2019

AbstractBackgroundThe quantity of metastases lesions is an important reference when it comes to making a more informed treatment decision for patients with colorectal cancer liver metastases. However, the molecular alterations in patients with different numbers of lesions have not been systematically studied.MethodsWe investigated somatic alterations and microsatellite instability (MSI) of liver metastases from patients with single, multiple or diffuse metastasis lesions. A new algorithm “Pathway Damage Score” was developed to comprehensively assess the functional impact of somatic alterations at the pathway level. Pathogenic pathways of different metastasis were identified and their prognosis effects were evaluated. Furthermore, the subnetworks and affected phenotypes of the altered genes in each pathogenic pathway were analyzed.ResultsSomatic alterations and altered genes occurred sporadically as well as in MSI state in different metastasis types, although MSS patients had more metastatic lesions than that of the MSI patients. Every metastasis group has their own pathogenic pathways and damaged “Cargo recognition for clathrin‐mediated endocytosis” is significantly associated with poor prognosis (P < 0.001). Further pathway subnetwork analysis showed that except conventional drivers, other genes could also contribute to metastasis formation.ConclusionsProgression of liver metastasis could be driven by the coefficient of all altered genes belonging to the pathways. Thus, compared to somatic alterations and genes, pathway level analysis is more reasonable for functional interpretations of molecular alterations in clinical samples.
Pulmonary mucosa‐associated lymphoid tissue lymphoma mimicking lung cancer
Authors: Miyazaki Shinichi , Hachiya Kensuke , Nara Yoshiharu , Ikeda Takuya 
Published: June 2019

AbstractPulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma is the most frequent subset of primary pulmonary lymphoma. MALT lymphoma may manifest as a solid mass, mimicking lung cancer.
Adaptive neuro‐fuzzy inference system–based energy conservation system for performance enhancement of MANET
Authors: Jegatheesan A , Kumar N Sathish , Palagan C Anna 
Published: June 2019

SummaryA mobile ad hoc network (MANET) is a network with dynamic topology and mobile nodes. Due to its dynamic nature, there is no central control. Hence, nodes communicate with other nodes through intermediate nodes. The intermediate nodes are normal nodes in the same network and assume the responsibility of forwarding packets on the route from source to destination. Along these lines, a MANET requires vitality effective directing conventions to sort out the power use and to improve battery usage. In this paper, an equipped convention is recommended that expends less vitality of portable hubs in MANETs that depend on the remaining edge vitality of adaptive network‐based fuzzy inference systems (ANFIS). The edge esteem is resolved dependent on the fluffy participation capacities. Basically, the area hubs of source are figured utilizing two components: encased locale and transferring district. The neighbor hubs pondered by those elements receive the greatest edge esteem that started utilizing ANFIS. The hub with the most extreme estimations of edge and separation is favored as the following bounce for the exchange. The exploratory outcome delineates that our convention can recognizably diminish the aggregate vitality utilization for all effectively transmitted bundles and expand the lifetimes of hubs, overwhelmingly in the high versatility condition.
On low‐power SoCs as storage bricks for Bioinformatics
Authors: Morganti Lucia , Corni Elena , Lama Luca , Pellegrino Carmelo , Zanon Boito Francieli , Merelli Ivan , D'Agostino Daniele , Cesini Daniele 
Published: June 2019

SummaryIn the perspective of energy‐efficient storage solutions supporting scientific computing, we investigate the possibility of using low‐power Systems‐On‐Chip (SoCs) as storage bricks of a BeeGFS file system in support of a realistic genome sequencing pipeline from Bioinformatics. Metadata and data performances of such a file system made of low‐power devices are assessed via various benchmarks for an increasing number of clients accessing the data, and compared to those achieved with traditional power‐hungry architectures with a similar BeeGFS setup. Then, we show how the sequencing information streamed by portable sequencing devices, such as the Oxford Nanopore MinION, can be managed by the underlying BeeGFS file system built with low‐power SoCs.
Spiny rat SRY lacks a long Q‐rich domain and is not stable in transgenic mice
Authors: Ogata Yuka , Nishikata Mana , Kitada Kazuhiro , Mizushima Shusei , Jogahara Takamichi , Kuroiwa Asato 
Published: June 2019

AbstractBackgroundAlthough Tokudaia muenninki has multiple extra copies of the Sry gene on the Y chromosome, loss of function of these sequences is indicated. To examine the Sry gene function for sex determining in T. muenninki, we screened a BAC library and identified a clone (SRY26) containing complete SRY coding and promoter sequences.ResultsSRY26 showed high identity to mouse and rat SRY. In an in vitro reporter gene assay, SRY26 was unable to activate testis‐specific enhancer of Sox9. Four lines of BAC transgenic mice carrying SRY26 were generated. Although the embryonic gonads of XX transgenic mice displayed sufficient expression levels of SRY26 mRNA, these mice exhibited normal female phenotypes in the external and internal genitalia, and up‐regulation of Sox9 was not observed. Expression of the SRY26 protein was confirmed in primate‐derived COS7 cells transfected with a SRY26 expression vector. However, the SRY26 protein was not expressed in the gonads of BAC transgenic mice.ConclusionsOverall, these results support a previous study demonstrated a long Q‐rich domain plays essential roles in protein stabilization in mice. Therefore, the original aim of this study, to examine the function of the Sry gene of this species, was not achieved by creating TG mice.
Phylogeography of Dendrolimus punctatus (Lepidoptera: Lasiocampidae): Population differentiation and last glacial maximum survival
Authors: Li Jing , Jin Qian , Zhu Geng‐ping , Jiang Chong , Zhang Ai‐bing 
Published: June 2019

AbstractAlthough the Masson pine moth, Dendrolimus punctatus, is one of the most destructive forest pest insects and is an endemic condition in China, we still do not fully understand the patterns of how its distribution range varies in response to Quaternary climatic oscillations. Here, we sequenced one maternally inherited mitochondrial gene (COI) and biparentally inherited nuclear data (ITS1 and ITS2) among 23 natural populations across the entire range of the species in China. A total of 51 mitotypes and 38 ribotypes were separately obtained using mtDNA and ITS1 data. Furthermore, significant phylogeographical structure (NST > GST, p < 0.01) were detected. The spatial distribution of mitotypes implied that two distinct groups existed in the species: one in the southwest distribution, including 10 locations, and the other located in the northeast region of China. It is suggested, therefore, that each group was derived from ancestors that occupied different isolated refugia during previous periods, possibly last glacial maximum. Mismatch distribution and Bayesian population dynamics analysis suggested the population size underwent sudden expansion, which is consistent with the results of ecological niche modeling. As a typical phytophagous insect, the history of population expansion was in accordance with the host plants, providing abundant food resources and habitat. Intraspecific success rate of barcoding identification was lower than interspecific ones, indicating a level of difficulty in barcoding individuals from different populations. However, it still provides an early insight into the pattern of genetic diversity within a species.OPEN RESEARCH BADGES

This article has been awarded an Open Data and Open Materials. All materials and data are publicly accessible via the Open Science Framework at https://doi.org/10.5061/dryad.2df87g2. Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/tvyxz/wiki.
Null model analyses of temporal patterns of bird assemblages and their foraging guilds revealed the predominance of positive and random associations
Authors: Korňan Martin , Svitok Marek , Krištín Anton 
Published: June 2019

AbstractPatterns of species associations have been commonly used to infer interactions among species. If species positively co‐occur, they may form predominantly neutral assemblages, and such patterns suggest a relatively weak role for compensatory dynamics. The main objective of this study was to test this prediction on temporal samples of bird assemblages (n = 19, 10–57 years) by the presence/absence and quantitative null models on assemblage and guild levels. These null model outcomes were further analyzed to evaluate the effects of various data set characteristics on the outcomes of the null models. The analysis of two binary null models in combination with three association indices revealed 20% with significant aggregations, 61% with random associations, and only 19% with significant segregations (n = 95 simulations). The results of the quantitative null model simulations detected more none‐random associations: 61% aggregations, 6% random associations, and 33% segregations (n = 114 simulations). Similarly, quantitative analyses on guild levels showed 58% aggregations, 20% segregations, and 22% random associations (n = 450 simulations). Bayesian GLMs detected that the outcomes of the binary and quantitative null models applied to the assemblage analyses were significantly related to census plot size, whereas the outcomes of the quantitative analyses were also related to the mean population densities of species in the data matrices. In guild‐level analyses, only 9% of the GLMs showed a significant influence of matrix properties (plot size, matrix size, species richness, and mean species population densities) on the null model outcomes. The results did not show the prevalence of negative associations that would have supported compensatory dynamics. Instead, we assume that a similar response of the majority of species to climate‐driven and stochastic factors may be responsible for the revealed predominance of positive associations.
Integration of ground survey and remote sensing derived data: Producing robust indicators of habitat extent and condition
Authors: Henrys Peter A. , Jarvis Susan G. 
Published: June 2019

AbstractThe availability of suitable habitat is a key predictor of the changing status of biodiversity. Quantifying habitat availability over large spatial scales is, however, challenging. Although remote sensing techniques have high spatial coverage, there is uncertainty associated with these estimates due to errors in classification. Alternatively, the extent of habitats can be estimated from ground‐based field survey. Financial and logistical constraints mean that on‐the‐ground surveys have much lower coverage, but they can produce much higher quality estimates of habitat extent in the areas that are surveyed. Here, we demonstrate a new combined model which uses both types of data to produce unified national estimates of the extent of four key habitats across Great Britain based on Countryside Survey and Land Cover Map. This approach considers that the true proportion of habitat per km2 (Zi) is unobserved, but both ground survey and remote sensing can be used to estimate Zi. The model allows the relationship between remote sensing data and Zi to be spatially biased while ground survey is assumed to be unbiased. Taking a statistical model‐based approach to integrating field survey and remote sensing data allows for information on bias and precision to be captured and propagated such that estimates produced and parameters estimated are robust and interpretable. A simulation study shows that the combined model should perform best when error in the ground survey data is low. We use repeat surveys to parameterize the variance of ground survey data and demonstrate that error in this data source is small. The model produced revised national estimates of broadleaved woodland, arable land, bog, and fen, marsh and swamp extent across Britain in 2007.
A review of protocols for the experimental release of kelp (Laminariales) zoospores
Authors: Alsuwaiyan Nahlah A. , Mohring Margaret B. , Cambridge Marion , Coleman Melinda A. , Kendrick Gary A. , Wernberg Thomas 
Published: June 2019

AbstractKelps (order Laminariales) are foundation species in temperate and arctic seas globally, but they are in decline in many places. Laminarian kelp have an alternation of generations and this poses challenges for experimental studies due to the difficulties in achieving zoospore release and gametophyte growth. Here, we review and synthesize the protocols that have been used to induce zoospore release in kelps to identify commonalities and provide guidance on best practices. We found 171 papers, where zoospore release was induced in four kelp families from 35 different ecoregions. The most commonly treated family was Laminariaceae, followed by Lessoniaceae and the most studied ecoregion was Central Chile, followed by the Southern California Bight. Zoospore release generally involved three steps: a pretreatment which included cleaning of the reproductive tissue to eliminate epiphytic organisms, followed by desiccation of the tissue, and finally a postdesiccation immersion of the reproductive material in a seawater medium for zoospore release. Despite these commonalities, there was a high degree of variation in the detail within each of these steps, even among studies within genera and from the same ecoregions. This suggests either that zoospore release may be relatively insensitive across the Laminariales or that little methods optimization has been undertaken. We suggest that greater attention to standardization of protocols and reporting of methodology and optimization would improve comparisons of kelp zoospore release across species and locations and facilitate a broader understanding of this key, but understudied life history stage.Open Research Badges
This article has earned an Open Data Badge for making publicly available the digitally‐shareable data necessary to reproduce the reported results. The data is available at https://doi.org/10.5061/dryad.0kh1f8j.
Rationale and design of the EMPERIAL‐Preserved and EMPERIAL‐Reduced trials of empagliflozin in patients with chronic heart failure
Authors: Abraham William T. , Ponikowski Piotr , Brueckmann Martina , Zeller Cordula , Macesic Hemani , Peil Barbara , Brun Michèle , Ustyugova Anastasia , Jamal Waheed , Salsali Afshin , Lindenfeld JoAnn , Anker Stefan D. ,   on behalf of the EMPERIAL Investigators and National Coordinators
Published: June 2019

AimsHeart failure (HF) is associated with considerable symptom burden and impairment in physical functioning and quality of life. The sodium–glucose co‐transporter 2 inhibitor empagliflozin reduced the risk of HF hospitalisation and cardiovascular death in patients with type 2 diabetes and established cardiovascular disease in the EMPA‐REG OUTCOME trial, and could potentially improve congestion symptoms and exercise capacity in patients with HF. We describe the designs of the EMPERIAL‐Preserved and EMPERIAL‐Reduced trials of empagliflozin in patients with chronic stable HF, with or without type 2 diabetes.MethodsEMPERIAL‐Preserved and EMPERIAL‐Reduced are randomised, placebo‐controlled trials designed to investigate the effects of empagliflozin on exercise capacity and patient‐reported outcomes in patients with chronic stable HF with preserved ejection fraction [HFpEF; left ventricular ejection fraction (LVEF) > 40%] and HF with reduced ejection fraction (HFrEF; LVEF ≤ 40%), respectively. In each trial, approximately 300 patients will be randomised 1:1 to receive empagliflozin 10 mg or placebo once daily for 12 weeks. In both trials, the primary endpoint is the change from baseline in 6‐min walk test distance at week 12. Key secondary endpoints are the change from baseline in Kansas City Cardiomyopathy Questionnaire total symptom score and change from baseline in dyspnoea score of the Chronic Heart Failure Questionnaire at week 12.ConclusionThe EMPERIAL‐Preserved and EMPERIAL‐Reduced trials will determine the effects of empagliflozin on exercise capacity and patient‐reported outcomes in patients with HFpEF and HFrEF, respectively, and provide insight into the potential of empagliflozin in the treatment of patients with HF.Clinical Trial Registration: ClinicalTrials.gov ID: NCT03448406 (EMPERIAL‐Preserved), NCT03448419 (EMPERIAL‐Reduced).