bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Patients With Fibromyalgia in a Prothrombotic State?
Authors: Molina Francisco , del Moral María Luisa , La Rubia Mercedes , Blanco Santos , Carmona Ramón , Rus Alma 
Published: January 2019

Objectives: The aim of this study was to investigate thrombosis-related parameters (blood coagulation parameters, platelet indices, red blood cell [RBC] count, and inflammatory markers) in patients with fibromyalgia (FM). Method: We carried out a case–control study with 35 women with FM and 12 age-matched healthy volunteers to analyze fibrinogen levels, prothrombin time, cephaline time, platelet count, platelet distribution width (PDW), mean platelet volume (MPV), RBC count, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio (PLR). Results: The results showed significantly increased fibrinogen levels ( p < .05), platelet count ( p < .05), PDW ( p = .059), RBC count ( p < .05), and PLR ( p < .05) in women with FM versus the healthy volunteers. Prothrombin time ( p < .05) and MPV ( p < .05) were significantly lower in patients with FM than in the controls. Conclusions: Elevated platelet and RBC counts, PDW values, and fibrinogen levels as well as decreased prothrombin time are all indicative of a prothrombotic state in FM patients, which may be enhanced by an increased inflammatory tone. This prothrombotic state may increase the risk of thrombosis-related cardiovascular disease in patients with FM.
Imaging correlates of hand motor performance in multiple sclerosis: A multiparametric structural and functional MRI study
Authors: Cordani Claudio , Meani Alessandro , Esposito Federica , Valsasina Paola , Colombo Bruno , Pagani Elisabetta , Preziosa Paolo , Comi Giancarlo , Filippi Massimo , Rocca Maria A 
Published: January 2019

Background: Hand motor impairment has considerable effects on daily-life activities of patients with multiple sclerosis (pwMS). Understanding its anatomo-functional substrates is relevant to provide more specific therapeutic interventions. Objectives: To investigate the association between hand motor performance and anatomo-functional magnetic resonance imaging (MRI) abnormalities in pwMS. Methods: A total of 134 healthy controls (HC) and 366 pwMS underwent the Nine-Hole-Peg-Test (9HPT), structural and resting state (RS) functional MRI. Multivariate analyses identified the independent predictors of hand motor performance. Results: PwMS versus HC showed widespread gray matter atrophy, microstructural white matter abnormalities, and decreased RS functional connectivity in motor and cognitive networks. Predictors of worse right-9HPT ( R2 = 0.52) were decreased right superior cerebellar peduncle and right lemniscus fractional anisotropy (FA) ( p ⩽ 0.02), left angular gyrus atrophy ( p < 0.003), decreased RS connectivity in left superior frontal gyrus, and left posterior cerebellum ( p < 0.001). Worse left 9HPT ( R2 = 0.56) was predicted by decreased right corticospinal FA ( p = 0.003), atrophy of left anterior cingulum and left cerebellum ( p ⩽ 0.02), decreased RS connectivity of left lingual gyrus and right posterior cerebellum in cerebellar and executive networks ( p ⩽ 0.02). Conclusion: Structural and functional abnormalities of regions involved in motor functions contribute to explain motor disability in pwMS. The integration of clinical and advanced MRI measures contributes to improve our understanding of multiple sclerosis clinical manifestations.
Impact of immunohistochemistry on the diagnosis and management of primary aldosteronism: An important tool for improved patient follow-up
Authors: Volpe C. , Hamberger B. , Zedenius J. , Juhlin C. C. 
Published: January 2019

Background and Aims: Primary aldosteronism is a common cause of secondary hypertension. Primary aldosteronism is caused by an aldosterone-producing adenoma or bilateral hyperplasia that in some cases is asymmetrical with one adrenal dominating aldosterone secretion. Most patients with aldosterone-producing adenoma are biochemically cured by unilateral adrenalectomy, but patients with bilateral hyperplasia have a significant risk of residual or recurrent disease. Here, immunohistochemistry of CYP11B1 and B2 was used to investigate whether these markers could aid in the diagnostic workup of primary aldosteronism patients. Materials and Methods: A total of 39 patients with primary aldosteronism who underwent unilateral adrenalectomy for a presumed adenoma during 2013–2016 were included. Immunohistochemistry using monoclonal antibodies identifying the enzymes CYP11B1 and B2 was part of routine histopathological workup in 6 cases; in 33 cases, it was applied retrospectively. The hyperplasia diagnosis was suggested when there was no dominating nodule but immunoreactivity for CYP11B2 was seen in several nodules, which were also seen on routine sections. To distinguish between adenoma and hyperplasia, a ratio between the largest and second largest CYP11B2-positive nodules was calculated. Results: In all, 22 patients had an aldosterone-producing adenoma, while 13 patients were judged to have hyperplasia. In four cases, a final diagnosis could not be established, thus these were judged equivocal. Among the 33 cases investigated retrospectively, the primary histopathological diagnosis was altered from hyperplasia to aldosterone-producing adenoma in 9 cases (27%) after immunohistochemistry, and the immunohistochemically rectified adenoma group displayed improved clinical cure rates compared to the routine H&E-diagnosed cohort. Moreover, the B2 ratio was significantly higher in adenoma than in hyperplasia and equivocal cases. Conclusion: Immunohistochemistry detecting CYP11B1 and B2 expression is of great help in establishing a final histopathological diagnosis in patients with primary aldosteronism. This procedure should be part of the histopathological routine in all operated primary aldosteronism patients.
The current treatment patterns of metastatic renal cell carcinoma: A national cancer database review, 2004–2015
Authors: Davaro Facundo , Schaefer Jared , May Allison , Raza Syed Johar , Siddiqui Sameer , Hamilton Zachary 
Published: January 2019

Objective: Our objective was to analyze patterns of treatment for metastatic renal cell carcinoma (mRCC) (no treatment (NT), cytoreductive nephrectomy only (CN), systemic therapy only (ST), and both systemic and cytoreductive (ST+CN)), and correlate them with racial or socioeconomic factors. Materials and Methods: Cases of mRCC from 2004–2015 were selected from the National Cancer Database. Our primary outcome was the temporal trend of treatment types. Secondary outcomes included the association of treatment with racial and socioeconomic factors. Logistical regression was performed. Results: In total, 40,372 patients with mRCC were identified. Treatment modalities included 37.0% NT, 13.9% CN only, 31.6% ST only and 17.5% ST+CN. From 2004–2015, NT decreased (53.4 vs. 32.1%, p < 0.001), CN alone decreased (18.1 vs. 12.1%, p < 0.001), ST alone increased (18.1 vs. 36.7%, p < 0.001) and ST+CN increased (10.3 vs. 19.1%, p < 0.001). On logistical regression, we found non-white races (odds ratio 1.29–1.73, p < 0.001), low-volume centers (hazard ratio (HR) 1.18, p < 0.001), no insurance (HR 2.29, p < 0.001) and low income (HR 1.24, p < 0.001) increased the likelihood of receiving NT. Conclusion: More patients are receiving ST and ST+CN; however, racial and socioeconomic factors may affect the treatment patterns for mRCC, and the underlying cause of these health disparities is unknown. Level of Evidence: 2c6
Musical and Teaching Identities in Action: A Case Study Research
Authors: Vico María del Carmen Guerrero 
Published: January 2019

This paper discusses the main characteristics of the identity of Jesús, a piano teacher at a professional music conservatory in Spain, as well as various aspects of his training, career and pedagogical approach. Using case studies as research methodology, it has been possible to examine how this professor articulates a shared identity between teaching and inter pretation. From the classification of states of identity proposed by Skorikov & Vondraek (2011) and Bouij (2004) it has also been possible to infer how, with respect to his profession, Jesús has gone through several states of identity throughout his career and how he currently integrates his musical skills into his pedagogy at the same time as he is interested in the teaching and development of students. From the data obtained, it can be concluded that, at least in his case, musical interpretation and teaching can be combined in a positive way and that although a traditional model of teaching instruments is used in conservatories, various resources can be integrated with which to improve the teaching and learning process.
Musical Conducting in the Guitárregas Guitar Ensemble: A Leadership Based on the Self-determination of Music Teachers
Authors: Angel-Alvarado Rolando , Gómez José Álamos 
Published: January 2019

The Self-Determination Theory (SDT) understands that self-determined people regulate their behaviour according to the pleasure perceived along the activity, so the leadership applied by management is determinant for promoting the self-determined behaviour. In this study, we will explain the self-determination encouraged by the Guitárregas' conductor to his students of the Bachelor degree in music education, according to SDT. The method responds to a qualitative design based on the hermeneutic approach. Data collection was carried out through a semi-structured interview. The results show that leadership encouraged by the conductor satisfies the innate psychological needs for autonomy, competence, and relatedness, so the director promotes the self-determined behaviour in his students. To conclude, Guitárregas is a reproducible project as long as the student musical background is valued, the repertoire contextualised, and the ensemble supported by an institution.
Unexpected visual improvement after aborted intracorneal ring segment implantation for keratoconus
Authors: Vastardis Iraklis , Thabit Ahmed , Elalfy Mohamed , Hamada Samer , Gatzioufas Zisis 
Published: January 2019

Purpose: To present a case of a complicated intracorneal ring segment (ICRS) implantation procedure in a patient with keratoconus, who experienced significant visual improvement, although the ICRS implantation had to be aborted. Methods: A 25-year-old female patient with keratoconus underwent femtosecond laser-assisted ICRS implantation in her right eye (OD) for improving visual acuity. Results: The procedure had to be aborted, because ICRS implantation was not possible. Anterior segment imaging 1 month after the procedure showed full-thickness corneal incision with corneal microperforation. However, patient’s visual acuity improved significantly due to amelioration of the keratometric findings. Keratometric and visual improvement was preserved at 6 months postoperatively. Conclusion: Our case report shows that femtosecond laser-assisted full-thickness corneal incision on the astigmatic axis combined with the intracorneal tunnel creation resulted unexpectedly in keratometric and visual improvement in this keratoconus patient, even without the implantation of the ICRS.
Pre-menstrual Dysphoric Disorder: A Review
Authors: Malvika Dahuja , Supriya Agarwal 
Published: January 2019

Introduction: Premenstrual dysphoric disorder (PMDD) is a distressing disorder amongst women of reproductive age group with significant implication in the productivity and quality of life of women who suffer from it. It is generally neglected as it is mostly undifferentiated from premenstrual symptoms—milder presentation of the same spectrum of problem but of lesser intensity and impairment. Objective: Here, in this article, we aim to highlight various studies and the research done on PMDD in the context of Indian women. Method: Reviewing the last 40 years’ database including Medline (PUBMED), Cochrane Library, EMBASE, Trip, Psych INFO, CINAHL, the Allied and Complementary Medicine Database (AMED), and the British Nursing Index. Results: PMDD is a troublesome disorder, often underdiagnosed. A thorough history including menstrual and sexual history, conducting a thorough physical examination, assessing the comorbidities, and finally using a proper and structured treatment protocol for managing the condition are recommended. Sertraline is the most widely studied drug which is found to be effective in PMDD.
A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease
Authors: Howard Jo , Hemmaway Claire Jane , Telfer Paul , Layton D. Mark , Porter John , Awogbade Moji , Mant Timothy , Gretler Daniel D. , Dufu Kobina , Hutchaleelaha Athiwat , Patel Mira , Siu Vincent , Dixon Sandra , Landsman Noel , Tonda Margaret , Lehrer-Graiwer Joshua 
Published: January 2019

Abstract
New treatments directly targeting polymerization of sickle hemoglobin (HbS), the proximate event in the pathophysiology of sickle cell disease (SCD), are needed to address the severe morbidity and early mortality associated with the disease. Voxelotor (GBT440) is a first-in-class oral therapy specifically developed to treat SCD by modulating the affinity of hemoglobin (Hb) for oxygen, thus inhibiting HbS polymerization and downstream adverse effects of hemolytic anemia and vaso-occlusion. GBT440-001 was a phase 1/2 randomized, double-blind, placebo-controlled, single and multiple ascending dose study of voxelotor in adult healthy volunteers and patients with SCD, followed by a single-arm, open-label extension study. This report describes results of voxelotor (500-1000 mg per day) in patients with sickle cell anemia. The study evaluated the safety, tolerability, pharmacokinetic, and pharmacodynamic properties of voxelotor and established proof of concept by improving clinical measures of anemia, hemolysis, and sickling. Thirty-eight patients with SCD received 28 days of voxelotor 500, 700, or 1000 mg per day or placebo; 16 patients received 90 days of voxelotor 700 or 900 mg per day or placebo. Four patients from the 90-day cohort were subsequently enrolled in an extension study and treated with voxelotor 900 mg per day for 6 months. All patients who received multiple doses of voxelotor for ≥28 days experienced hematologic improvements including increased Hb and reduction in hemolysis and percentage of sickled red cells, supporting the potential of voxelotor to serve as a disease-modifying therapy for SCD. Voxelotor was well tolerated with no treatment-related serious adverse events and no evidence of tissue hypoxia. These trials were registered at www.clinicaltrials.gov as #NCT02285088 and #NCT03041909.
A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403
Authors: Stock Wendy , Luger Selina M. , Advani Anjali S. , Yin Jun , Harvey Richard C. , Mullighan Charles G. , Willman Cheryl L. , Fulton Noreen , Laumann Kristina M. , Malnassy Greg , Paietta Elisabeth , Parker Edy , Geyer Susan , Mrózek Krzysztof , Bloomfield Clara D. , Sanford Ben , Marcucci Guido , Liedtke Michaela , Claxton David F. , Foster Matthew C. , Bogart Jeffrey A. , Grecula John C. , Appelbaum Frederick R. , Erba Harry , Litzow Mark R. , Tallman Martin S. , Stone Richard M. , Larson Richard A. 
Published: January 2019

Abstract
Retrospective studies have suggested that older adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) have better survival rates when treated using a pediatric ALL regimen administered by pediatric treatment teams. To address the feasibility and efficacy of using a pediatric treatment regimen for AYA patients with newly diagnosed ALL administered by adult treatment teams, we performed a prospective study, CALGB 10403, with doses and schedule identical to those in the Children's Oncology Group study AALL0232. From 2007 to 2012, 318 patients were enrolled; 295 were eligible and evaluable for response. Median age was 24 years (range, 17-39 years). Use of the pediatric regimen was safe; overall treatment-related mortality was 3%, and there were only 2 postremission deaths. Median event-free survival (EFS) was 78.1 months (95% confidence interval [CI], 41.8 to not reached), more than double the historical control of 30 months (95% CI, 22-38 months); 3-year EFS was 59% (95% CI, 54%-65%). Median overall survival (OS) was not reached. Estimated 3-year OS was 73% (95% CI, 68%-78%). Pretreatment risk factors associated with worse treatment outcomes included obesity and presence of the Philadelphia-like gene expression signature. Use of a pediatric regimen for AYAs with ALL up to age 40 years was feasible and effective, resulting in improved survival rates compared with historical controls. CALGB 10403 can be considered a new treatment standard upon which to build for improving survival for AYAs with ALL. This trial was registered at www.clinicaltrials.gov as #NCT00558519.
Management of direct factor Xa inhibitor–related major bleeding with prothrombin complex concentrate: a meta-analysis
Authors: Piran Siavash , Khatib Rasha , Schulman Sam , Majeed Ammar , Holbrook Anne , Witt Daniel M. , Wiercioch Wojtek , Schünemann Holger J. , Nieuwlaat Robby 
Published: January 2019

Abstract
A targeted antidote for reversal of direct factor Xa (FXa) inhibitors is now available for clinical use in the United States, but it is costly and has limited availability. In a systematic review, we evaluated the safety and effectiveness of 4-factor prothrombin complex concentrate (4F-PCC) as an alternative for managing direct FXa inhibitor–related major bleeding. A systematic literature search was conducted using Medline, Embase, and the Cochrane Register of Controlled Trials up to September 2018. No comparative studies were found. Ten case series with 340 patients who received PCC for direct FXa inhibitor–related major bleeding were included. The pooled proportion of patients with effective management of major bleeding was 0.69 (95% confidence interval [CI], 0.61-0.76) in 2 studies using the International Society on Thrombosis and Haemostasis (ISTH) criteria and 0.77 (95% CI, 0.63-0.92) in 8 studies that did not use the ISTH criteria; all-cause mortality was 0.16 (95% CI, 0.07-0.26), and thromboembolism rate was 0.04 (95% CI, 0.01-0.08). On the basis of evidence with very low certainty from single-arm case series, it is difficult to determine whether 4F-PCC in addition to cessation of direct oral FXa inhibitor is more effective than cessation of direct oral FXa inhibitor alone in patients with direct FXa inhibitor–related major bleeding.
A Black Panther in the Tropics
Authors: Germain Félix 
Published: January 2019

AbstractLike most young men of the postwar era, Pierre-Just Marny (1943–2011), a Martinican man of humble origin, expected to reap the benefits of departmentalization. But in the late 1950s, against all expectations, he became an outlaw. In 1965, after committing violent crimes, he called himself La Panthère Noire (the Black Panther), a Hollywood-inspired name characterizing his courage and fearlessness. Marny, who has fallen through the cracks of French history, is an important historical subject because his adventures, killings, and struggle against the French police; his sentence to life in prison; and ultimately his struggle for freedom became intertwined with the complex relationship that Martinique has developed with France since departmentalization.Comme la plupart des jeunes hommes de la période de l'après-guerre, Pierre-Juste Marny (1943–2011), un Martiniquais d'origine modeste, espérait récolter les bénéfices de la départementalisation. Mais à la fin des années 1950, contre toute attente, il devint un hors-la-loi. En 1965, après une série de crimes violents, le jeune Marny se fit appeler La Panthère Noire, un surnom inspiré d'Hollywood illustrant son intrépidité. Oublié par les chercheurs, Marny est un sujet important de l'histoire contemporaine parce que ses aventures en Martinique, ses meurtres, sa lutte contre la police, son emprisonnement à perpétuité, et sa bataille pour retrouver la liberté s'entremêlent avec la relation compliquée entre la Martinique et la France depuis la départementalisation.
The US Secret War in Laos
Authors: Sisavath Davorn 
Published: January 2019

AbstractThis article complicates and challenges the existing records on US-Lao relations during the Second Indochina War by examining military waste in Laos as an archive. Over two million tons of bombs were dropped during US bombing in Laos from 1964 to 1973. Today, Laos remains the most heavily bombed country per capita, where more than 580,000 bombing missions were conducted (the equivalent of one raid every eight minutes for nine years). The war metal and scraps that saturate northern Laos motivated my examination of an alternative archive, as have incomplete records—those restricted or absented—in the state archive. Located in the massive accumulation of military waste, these archives tell a different story about the war by highlighting the convergence of militarism and capitalism that led to the production of bombs and that continue to shape life-making practices in the war’s aftermath.
Tau regulates the microtubule-dependent migration of glioblastoma cells via the Rho-ROCK signaling pathway
Authors: Breuzard Gilles , Pagano Alessandra , Bastonero Sonia , Malesinski Soazig , Parat Fabrice , Barbier Pascale , Peyrot Vincent , Kovacic Hervé 
Published: January 2019

ABSTRACT
The pathological significance of Tau (encoded by MAPT) in mechanisms driving cell migration in glioblastoma is unclear. By using an shRNA approach to deplete microtubule-stabilizing Tau in U87 cells, we determined its impact on cytoskeletal coordination during migration. We demonstrated here that the motility of these Tau-knockdown cells (shTau cells) was significantly (36%) lower than that of control cells. The shTau cells displayed a slightly changed motility in the presence of nocodazole, which inhibits microtubule formation. Such reduced motility of shTau cells was characterized by a 28% lower number of microtubule bundles at the non-adhesive edges of the tails. In accordance with Tau-stabilized microtubules being required for cell movement, measurements of the front, body and rear section displacements of cells showed inefficient tail retraction in shTau cells. The tail retraction was restored by treatment with Y27632, an inhibitor of Rho-ROCK signaling. Moreover, we clearly identified that shTau cells displayed relocation of the active phosphorylated form of p190-RhoGAP (also known as ARHGAP35), which inhibits Rho-ROCK signaling, and focal adhesion kinase (FAK, also known as PTK2) in cell bodies. In conclusion, our findings indicate that Tau governs the remodeling of microtubule and actin networks for the retraction of the tail of cells, which is necessary for effective migration.