bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stage-Specific Tumoral Gene Expression Profiles of Black and White Patients with Colon Cancer
Authors: El Moheb Mohamad , Shen Chengli , Kim Susan , Putman Kristin , Zhang Hongji , Ruff Samantha M. , Witt Russell , Tsung Allan 
Published: November 2024

Abstract
Background
Black patients with colon cancer (CC) exhibit more aggressive tumor biology and higher treatment resistance than white patients, even after adjusting for clinical and demographic factors. We investigated stage-specific transcriptional differences in tumor profiles of Black and white patients with CC.

Patients and Methods
Patients with CC from The Cancer Genome Atlas Colon Adenocarcinoma database were categorized by disease stage and propensity-score matched between Black and white patients. Differential gene expression and pathway enrichment analyses were performed for each stage. Logistic regression and quadratic discriminant analysis (QDA) models were developed using consistently differentially expressed genes.

Results
Of 247 patients, 128 had localized (22% Black), 81 had regional (74% Black), and 38 had distant disease (29% Black). Differential expression analysis revealed differences in 312 genes for localized, 105 for regional, and 199 for distant stages between Black and white patients. Pathway enrichment analysis showed downregulation of the IL-17 pathway in Black patients with localized disease. In total, five genes exhibited race-specific transcriptional differences across all stages: RAMACL, POLR2J3, POLR2J2, MUC16, and PRSS21. Logistic regression and QDA model performance indicated that these genes represent racial differences [area under the receiver operating characteristic curve (AUC): 0.863 and 0.880].

Conclusions
Significant transcriptional differences exist in CC between Black and white patients changing dynamically across disease stages, and involving genes with broad functions. Key findings include IL-17 pathway downregulation in Black patients with localized disease and a five-gene signature consistent across all stages. These findings may explain aspects of racial disparities in CC, emphasizing the need for race-specific research and treatment strategies.
The art of clinical shade matching of resin-based composite materials
Authors: Parmar Dipesh , Mackenzie Louis , Bonsor Stephen J 
Published: November 2024

The present article is the second in a series of three on shade matching in restorative dentistry. The first article provided an overview and general advice on shade taking. This article goes on to discuss what factors should be considered when choosing the most appropriate shade guide in relation to resin-based composite materials. It offers practical advice on how shade guides may be used to best effect in determining an optimal match with respect to optics between the dental hard tissues and resin-based composite products to achieve highly natural imperceptible results when working in the aesthetic zone. CPD/Clinical Relevance: The art of shade matching is a fundamental clinical skill in restorative dentistry to ensure that the best possible aesthetic outcome is achieved when working with resin-based composite materials.
Porcelain rehabilitation of the maxillary arch following clear aligner orthodontic treatment
Authors: O'Neill Gary 
Published: November 2024

This case report outlines a comprehensive pre-operative assessment followed by clear aligner orthodontic treatment and the placement of porcelain veneer restorations at the maxillary arch. The patient sought the replacement of existing direct and indirect restorations. Clear aligner treatment, using the Invisalign system (Align Technology, AZ, USA), was administered over 21 weeks to address moderate contact point displacement in the anterior sextants. Subsequently, minimally invasive porcelain veneers were provided anteriorly, alongside posterior cuspal coverage restorations. CPD/Clinical Relevance: To highlight the significance of pre-restorative orthodontic treatment in optimizing aesthetics and enabling the delivery of minimally invasive restorative procedures.
Effects of Bioprosthetic Valve Fracturing on Valve-in-Valve Transcatheter Aortic Valve Implantation Transvalvular Gradients
Authors: Hallak Osama , Fischer Karley , Ailawadi Shaina , Valencia Damian , Yatsynovich Yan , Nazir Raja , Schwartz Brian 
Published: November 2024

Abstract

Background:
Valve-in-valve (ViV) transcatheter aortic valve implantation (TAVI) is quickly becoming a routine and effective means by which to treat degenerated bioprosthetic valves. A known complication of ViV-TAVI is patient-prosthesis mismatch, which substantially affects survival. Bioprosthetic valve fracture is a method by which to reduce the risk of patient-prosthesis mismatch and post–ViV-TAVI transvalvular gradients. This study sought to determine the safety and efficacy of post–ViV-TAVI bioprosthetic valve fracture.

Methods:
Patients with a history of surgical aortic valve replacement undergoing ViV-TAVI bioprosthetic valve fracture (N = 25) at the corresponding institution from 2015 to 2022 were cataloged for a retrospective analysis. The implanted transcatheter valves were Medtronic Evolut R, Evolut PRO, and Evolut PRO+. Gradients were assessed before and after implantation and after fracturing using transthoracic echocardiogram.

Results:
The mean left ventricular ejection fraction of patients who underwent fracturing was 55.04%. The average (SD) peak and mean (SD) transvalvular gradients before the intervention were 68.17 (19.09) mm Hg and 38.98 (14.37) mm Hg, respectively. After ViV-TAVI, the same gradients were reduced to 27.25 (12.27) mm Hg and 15.63 (6.47) mm Hg, respectively. After bioprosthetic valve fracture, the gradients further decreased to 17.59 (7.93) mm Hg and 8.860 (3.334) mm Hg, respectively. The average reduction in peak gradient associated with fracturing was 12.07 mm Hg (95% CI, 5.73-18.41 mm Hg; P = .001). The average reduction in mean gradient associated with valve fracturing was 6.97 mm Hg (95% CI, 3.99-9.74 mm Hg; P < .001).

Conclusion:
Bioprosthetic valve fracture is a viable option for reducing residual transvalvular gradients after ViV-TAVI and should be considered in patients with elevated gradients (>20 mm Hg) or with concern for patient-prosthesis mismatch in patients who have an unacceptable risk for a redo sternotomy and surgical aortic valve replacement.
A Comprehensive Review of Atrial Infarction
Authors: Grosso Domenic , Dickman Jacob , Valencia Damian 
Published: November 2024

Abstract
Atrial infarction is often undiagnosed in patients with underlying ischemic heart disease and is identified only later, upon autopsy. One of the main challenges in diagnosing the condition is its localization within the affected atria. Treatment of atrial infarction focuses on acute reperfusion therapy, long-term management of cardiovascular disease risk factors, consideration of antiarrhythmia medications, and anticoagulation therapy. This review covers the anatomy of the atrial vasculature, complications associated with atrial infarction, diagnostic criteria for use of electrocardiography and other imaging modalities, and overall prognosis and management.
Editorial Introduction: In the Face of Urgency, Making Space for the Emerging
Authors: Desimoni Victoria , Stone Courtney , Kim Minji , Chaomuangkhong Tipsuda 
Published: November 2024

This Editorial Introduction reflects on the challenges and complexities facing education amidst political, social, and environmental crises, emphasizing the need to engage with emerging solutions rather than being paralyzed by urgency. In the context of the current multicrisis, it envisions CIE as a beacon of hope—a space to step back and recognize emerging efforts. We call for slowing down, not as a passive act but as an active effort to nurture the possibilities arising from these crises. The introduction highlights the five articles in this issue, featuring scholars addressing real problems in education, exploring alternatives, and uncovering unexpected possibilities. From teaching white nationalism in the Trump era to navigating the challenges faced by women in online doctoral programs, or examining skateboarding as a counterculture in higher education, these studies illuminate the layered realities of education and society.
Glenn circulation causes early and progressive shunting in a surgical model of pulmonary arteriovenous malformations
Authors: Wan Tina C. , Rousseau Henry , Mattern Carol , Tabor Madeline , Hodges Matthew R. , Ramchandran Ramani , Spearman Andrew D. 
Published: November 2024

AbstractPulmonary arteriovenous malformations (PAVMs) universally develop in patients with single ventricle congenital heart disease. Single ventricle PAVMs have been recognized for over 50 years but remain poorly understood. To improve our understanding, we developed a surgical rat model of Glenn circulation and characterized PAVM physiology over multiple time points. We performed a left thoracotomy and end‐to‐end anastomosis of the left superior vena cava to the left pulmonary artery (unilateral Glenn), or sham surgical control. To assess PAVM physiology, we quantified intrapulmonary shunting using two independent methods (bubble echocardiography and fluorescent microsphere injection). Additionally, we performed arterial blood gas measurements to assess oxygenation and plethysmography to assess ventilation. We identified pathologic intrapulmonary shunting by bubble echocardiography as early as 2 weeks post‐Glenn, and shunting continued at 2‐ and 6‐months post‐Glenn. Shunting also progressed over time, demonstrated by increased shunting of 10 μm microspheres at 6 months. Shunting was accompanied by mildly decreased oxygenation but no differences in ventilation. Our surgical animal model of unilateral Glenn circulation recreates the clinical condition of single ventricle PAVMs with early and progressive intrapulmonary shunting. This model is poised to characterize single ventricle PAVM pathophysiology and lead to mechanistic and therapeutic discovery.
Русская фольклорная загадка: лингвокогнитивный анализ речевого жанра
Authors: Бузальская Елена Валериановна 
Published: November 2024

Аннотация
Целью статьи является лингвокогнитивное описание речевого жанра «загадка» и определение его основных вариантов. В рамках теории речевых жанров «загадка» является малоформатным, простым, вторичным косвенным речевым жанром, изначально связанным с мифологической картиной мира. Прагмалингвистически речевой жанр «загадка» ориентирован на речевую стратегию загадывания (кодирования заранее известного спрашивающему объекта), которая реализуется при помощи деиктических речевых тактик. В результате предпринятого анализа речевого жанра фольклорной загадки выделено 6 основных лингвокогнитивных структур (12 вариантов в поле вариативности модели жанра) на основании следующих групп характеристик: (1) концептуально-когнитивных характеристик (структурной принадлежности к гештальту, фрейму или сценарию); (2) типа речевой тактики (поддержки стереотипа или его разрушения); (3) появления одушевленности в результате метафорического переноса. Внутри данных групп автор выделяет подгруппы, которые связаны с полнотой описания загадываемого объекта.
Compartmental modeling approach for prediction of unreported cases of COVID-19 with awareness through effective testing program
Authors: Singh Abhishekh , Rana Vikash , Verma Vijai Shanker 
Published: November 2024

Abstract
The objective of this article is to study the compartmental modeling approach for the prediction of unreported cases of coronavirus disease 2019 by considering six compartments. Our model is described by a system of six ordinary differential equations with initial conditions. The basic properties of solution of the model are established. The model is shown to have two equilibrium points, i.e., the disease-free and endemic equilibrium points. The basic reproduction number

R

0

{R}_{0}

is derived by the next-generation matrix method. Stability analysis is carried out in the study. Furthermore, sensitivity analysis is also performed to identify the impact of important parameters that significantly affect

R

0

{R}_{0}

. Numerical simulations provide a good approximation model for COVID-19, which will be utilized to investigate future pandemic with similar nature of spread as COVID-19 and estimate the number of unreported cases worldwide.
Modeling the kinetics, energy consumption and shrinkage of avocado pear pulp during drying in a microwave assisted dryer
Authors: Ehiem James Chinaka , Oduma Okechukwu , Igbozulike Austin O. , Raghavan Vijayan G. S. , Aviara Ndubisi A. 
Published: November 2024

Abstract
Drying kinetics, energy utilization (EU) and shrinkage level of avocado pear pulp during drying were investigated and modeled to determine the condition that enhances the quality of the dried product. Drying was carried out using a microwave assisted dryer with data lodger. The system was set at a constant power of 200 W, air velocity of 1.4 m/s, and temperatures of 50, 60 and 70 °C with pulp thickness being 5 mm. Fifteen thin-layer drying models, five non-linear shrinkage models and ANN methods were tested for describing the drying behaviour of avocado pulp using statistical parameters. The results revealed that drying took place in the falling rate period with the above temperatures reducing the moisture content of the pulp from 64.12 to 2.16 % wet basis within 15,360, 11,520 and 5,130 s, respectively. The drying rate and effective diffusivity increased with increase in temperature and ranged from 6.05 × 10−3 to 1.70 × 10−2 kg/kgs and 3.11 to 9.34 × 10−9 m2/s, respectively. The activation energy of the pulp was 50.34 kJ/mol. Among the drying models tested, Page and Aghashilo models provided the best statistical parameters for describing the drying behaviour of the pulp, while ANN demonstrated great ability to predict MR and SR more accurately with high and low R2 and RMSE. A non-linear shrinkage model developed also had the best fit qualities for describing the shrinkage behaviour of the pulp. The energy utilized (EU), specific energy utilized (S

EU

), heat transfer coefficient (h

tc

) and mass transfer coefficient (M

tc

) of the pulp ranged from 7.36 to 3.19 kWh, 11.21 to 5.76 × 10−2 Wh/kg, 0.1054 to 7.98 × 10−7 W/mK and 2.06 to 4.28 × 10−6 m/s respectively and were statistically (5 %) influenced by temperature. The EU model developed had the best description behaviour of the energy relationship with other factors, having high R2 and low RMSE and SSE values.
Cartography of Cultural Practices and Promoting Creative Policies for an Educating City
Authors: Mesías-Lema José María , Carla Álvarez-Barrio , Sabela Eiriz , Yamilé Pérez-Guilarte 
Published: November 2024

Abstract
This article results from a knowledge transfer report commissioned by the Culture Area of the A Coruña City Council in Galicia (Spain), a city with an average population of 250,000 inhabitants. The report’s goal was to map all the cultural actions happening in the city. Due to their variety, dispersion, and multiplicity, the local government’s culture department required a comprehensive catalogue of these practices. The initial challenge was to collect and structure the information to create a visual atlas that would allow for the mapping of these activities, identifying potentialities, shortcomings, and weaknesses to establish future cultural action lines. As a result of investigative and fieldwork, it was decided to document the actions carried out by both public and private institutions, whether conducted by the City Council’s culture department, funded externally, or independent. This information was analysed to draw conclusions for planning the city’s cultural future.
Trends of diagnostic adverse events in hospital deaths: longitudinal analyses of four retrospective record review studies
Authors: Hooftman Jacky , Zwaan Laura , Sikkens Jonne J. , Schouten Bo , de Bruijne Martine C. , Wagner Cordula 
Published: November 2024

Abstract

Objectives
To investigate longitudinal trends in the incidence, preventability, and causes of DAEs (diagnostic adverse events) between 2008 and 2019 and compare DAEs to other AE (adverse event) types.

Methods
This study investigated longitudinal trends of DAEs using combined data from four large Dutch AE record review studies. The original four AE studies included 100–150 randomly selected records of deceased patients from around 20 hospitals in each study, resulting in a total of 10,943 patient records. Nurse reviewers indicated cases with potential AEs using a list of triggers. Subsequently, experienced physician reviewers systematically judged the occurrence of AEs, the clinical process in which these AEs occurred, and the preventability and causes.

Results
The incidences of DAEs, potentially preventable DAEs and potentially preventable DAE-related deaths initially declined between 2008 and 2012 (2.3 vs. 1.2; OR=0.52, 95 % CI: 0.32 to 0.83), after which they stabilized up to 2019. These trends were largely the same for other AE types, although compared to DAEs, the incidence of other AE types increased between 2016 (DAE: 1.0, other AE types: 8.5) and 2019 (DAE: 0.8, other AE types: 13.0; rate ratio=1.88, 95 % CI: 1.12 to 2.13). Furthermore, DAEs were more preventable (p<0.001) and were associated with more potentially preventable deaths (p=0.016) than other AE types. In addition, DAEs had more and different underlying causes than other AE types (p<0.001). The DAE causes remained stable over time, except for patient-related factors, which increased between 2016 and 2019 (29.5 and 58.6 % respectively, OR=3.40, 95 % CI: 1.20 to 9.66).

Conclusions
After initial improvements of DAE incidences in 2012, no further improvement was observed in Dutch hospitals in the last decade. Similar trends were observed for other AEs. The high rate of preventability of DAEs suggest a high potential for improvement, that should be further investigated.
The twinned crystal structure of 10-(4-methyl benzoate)-2,8-diethyl-5,5-difluoro-1,3,7,9-tetramethyl-5H-di-pyrrolo[1,2-c:2′,1′-f] [1,3,2]diazaborinin-4-ium-5-uide, C25H29BF2N2O2
Authors: Usman Rabia , Bin-Jumah May Nasser , Altamimi Abeer A. , Baeshen Kholoud A. , Feng Chao , Al-Qhatani Mohsen Mohammed , Henidi Hanan A. 
Published: November 2024

Abstract
C25H29BF2N2O2, triclinic,

P
1

$P1$

(no. 1), a = 7.5649(4) Å, b = 7.6172(5) Å, c = 10.4163(6) Å, α = 73.672(5)°, β = 78.776(5)°, γ = 82.641(5)°, V = 563.28(6) Å3, Z = 1, R

gt
(F) = 0.0390, wR

ref
(F
2) = 0.1081, T = 150 K.
The crystal structure of methyl 4-(4-(methylsulfonyl)phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C19H21NO5S
Authors: Li Yaoyao , Su Lai , Wang Tianqin , Zhang Le 
Published: November 2024

Abstract
C19H21NO5S, triclinic, P1̄ (no. 2), a = 8.428(2) Å, b = 10.638(3) Å, c = 11.177(3) Å, α = 63.125(4)∘, β = 77.819(4)∘, γ = 79.845(4)∘, V = 869.9(4) Å3, Z = 2, R
gt
(F) = 0.0472, wR
ref
(F
2
) = 0.1379, T = 296(2) K.
Beyond the Dichotomy of Literal and Metaphorical Language in the Context of Contemporary Physics
Authors: Bradonjić Kaća 
Published: November 2024

Abstract
Working in the framework of object-oriented ontology, Graham Harman claims that science strictly adheres to literal language as opposed to metaphorical language. In this article, I argue that such a distinction between literal and metaphorical language cannot be made cleanly in the context of contemporary physics. First, I identify aspects of scientific practice that point to non-literalism, which include non-linguistic elements of scientific discourse, the problem of interpretation of mathematical formulations of some theories, and the acceptance of incompatible theories that describe the same object. Second, I outline an argument that at least some theories in physics constitute complex metaphors based on Harman’s own definition.
Identifying key biomarkers and therapeutic candidates for post-COVID-19 depression through integrated omics and bioinformatics approaches
Authors: Zhou Yi , Yang Chunhua , Zhou Jing , Zhang Qiyao , Sui Xingling , Dong Hongyu , Zhang Haidong , Wang Yue 
Published: November 2024

Abstract

Introduction
Depression, the leading cause of disability worldwide, is known to be exacerbated by severe acute respiratory syndrome coronavirus 2 infection, worsening coronavirus disease 2019 (COVID-19) outcomes. However, the mechanisms and treatments for this comorbidity are not well understood.

Methods
This study utilized Gene Expression Omnibus datasets for COVID-19 and depression, combined with protein–protein interaction networks, to identify key genes. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to understand gene functions. The CIBERSORT algorithm and NetworkAnalyst were used to examine the relationship of immune cell infiltration with gene expression and to predict transcription factors (TFs) and microRNAs (miRNAs) interactions. The Connectivity Map database was used to predict drug interactions with these genes.

Results

TRUB1, PLEKHA7, and FABP6 were identified as key genes enriched in pathways related to immune cell function and signaling. Seven TFs and nineteen miRNAs were found to interact with these genes. Nineteen drugs, including atorvastatin and paroxetine, were predicted to be significantly associated with these genes and potential therapeutic agents for COVID-19 and depression.

Conclusions
This research provides new insights into the molecular mechanisms of post-COVID-19 depression and suggests potential therapeutic strategies, marking a step forward in understanding and treating this complex comorbidity.
Space sustainability: Current regulatory challenges
Authors: Bartóki-Gönczy Balázs , Ganczer Mónika , Sulyok Gábor 
Published: November 2024

AbstractNowadays, outer space is becoming increasingly congested, contested and competitive. Humanity's growing dependence on outer space and experiences with the new space race have necessarily turned the attention of the international community to the safety, security and sustainability of space activities. This paper focuses on space sustainability and seeks to highlight some of its most important regulatory challenges. These challenges include the establishment of an appropriate space traffic management system, the mitigation of space debris, and the utilization of space resources. Following the overview of related problems, the paper examines the urgency and the modalities of appropriate legal regulation.