bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Review on Kinematic Assessments of Upper Limb Movements After Stroke
Authors: Schwarz Anne , Kanzler Christoph M. , Lambercy Olivier , Luft Andreas R. , Veerbeek Janne M. 
Published: February 2019

Background and Purpose—
Assessing upper limb movements poststroke is crucial to monitor and understand sensorimotor recovery. Kinematic assessments are expected to enable a sensitive quantification of movement quality and distinguish between restitution and compensation. The nature and practice of these assessments are highly variable and used without knowledge of their clinimetric properties. This presents a challenge when interpreting and comparing results. The purpose of this review was to summarize the state of the art regarding kinematic upper limb assessments poststroke with respect to the assessment task, measurement system, and performance metrics with their clinimetric properties. Subsequently, we aimed to provide evidence-based recommendations for future applications of upper limb kinematics in stroke recovery research.

Methods—
A systematic search was conducted in PubMed, Embase, CINAHL, and IEEE Xplore. Studies investigating clinimetric properties of applied metrics were assessed for risk of bias using the Consensus-Based Standards for the Selection of Health Measurement Instruments checklist. The quality of evidence for metrics was determined according to the Grading of Recommendations Assessment, Development, and Evaluation approach.

Results—
A total of 225 studies (N=6197) using 151 different kinematic metrics were identified and allocated to 5 task and 3 measurement system groups. Thirty studies investigated clinimetrics of 62 metrics: reliability (n=8), measurement error (n=5), convergent validity (n=22), and responsiveness (n=2). The metrics task/movement time, number of movement onsets, number of movement ends, path length ratio, peak velocity, number of velocity peaks, trunk displacement, and shoulder flexion/extension received a sufficient evaluation for one clinimetric property.

Conclusions—
Studies on kinematic assessments of upper limb sensorimotor function are poorly standardized and rarely investigate clinimetrics in an unbiased manner. Based on the available evidence, recommendations on the assessment task, measurement system, and performance metrics were made with the goal to increase standardization. Further high-quality studies evaluating clinimetric properties are needed to validate kinematic assessments, with the long-term goal to elucidate upper limb sensorimotor recovery poststroke.

Clinical Trial Registration—

URL:
https://www.crd.york.ac.uk/prospero/
. Unique identifier: CRD42017064279.
Two new species of the genus Potentilla (Rosaceae) from North of Iran
Authors: NAQINEZHAD ALIREZA , FAGHIR MARZIEH BEYGOM 
Published: February 2019

Potentilla sangedehensis and Potentilla diversidentata are two new species collected from high montane areas of Sangedeh, Central Hyrcanian region, North of Iran. The former is related to the representatives of the section Curvisetae especially P. collettiana, P. curviseta and P. pteropoda and the later can be classified in the section Persicae, the most species–rich section in Iran. Detailed morphological descriptions of the new species, their photographs, and comparison of diagnostic traits with allied species are provided.
Effects of work conditions on suicidal ideation among middle-aged adults in South Korea
Authors: Park Sang-Mi 
Published: February 2019

Background: Korea has the highest rate of suicide in the world and has held this rank for the last decade. Suicide has risen especially sharply among 45- to 54-year-old Koreans; there were about 32.1 suicides per 100,000 individuals in 2015, and this contributed significantly to the rising suicide rate in Korea. Recently, adverse work conditions, including insecure employment and shift work, have been suggested as a suicide risk factor. However, little is known about the influence of insecure employment on suicidal ideation among middle-aged adults. Furthermore, prior research has examined the association between shift work and suicidal ideation only among individuals engaged in specific jobs, such as police work or firefighting, and those investigations have not focused on middle-aged adults. Aim: This study investigated the influence of employment status and shift work on suicidal ideation among middle-aged adults. Methods: The sample comprised waged, middle-aged adult employees ( n = 2,364) aged 45–64 years who had participated in the cross-sectional Korea National Health and Nutrition Examination Survey 2015. Using multivariate logistic regression analyses, this study evaluated the associations of employment status and shift work with suicidal ideation among middle-aged adults. Results: The major finding was that insecure employment status was independently associated with suicidal ideation in middle-aged adults (odds ratio (OR) = 2.50, 95% confidence interval (CI) = [1.27, 4.94]) and that shift work was significantly associated with suicidal ideation among middle-aged adults (OR = 2.30, 95% CI = [1.14, 4.66]). Conclusions: The findings of this study highlight the need for multidimensional interventions regarding suicide, especially for middle-aged adults engaged in insecure jobs and shift work. Multidimensional interventions, including early screening for suicidal thoughts during routine medical check-ups, readily available work-based counselling programmes and regular monitoring, are likely to be useful.
Hypoperfusion in lenticulostriate arteries territory related to unexplained early neurological deterioration after intravenous thrombolysis
Authors: Zhou Ying , Zhong Wansi , Wang Anli , Huang Wanyun , Yan Shenqiang , Zhang Ruiting , Liu Chang , Fu Jingjing , Jiaerken Yeerfan , Lou Min 
Published: February 2019

Background Early neurological deterioration occurs in approximately 10% acute ischemic stroke patients after thrombolysis. Over half of the early neurological deterioration occurred without known causes and is called unexplained early neurological deterioration. Aims We aimed to explore the development of early neurological deterioration at 24 h after thrombolysis, and whether it could be predicted by the presence of baseline hypoperfusion in lenticulostriate arteries territory in acute ischemic stroke patients. Methods We retrospectively reviewed our prospectively collected database of acute ischemic stroke patients in the unilateral middle cerebral artery territory who had baseline perfusion image and received thrombolysis. Unexplained early neurological deterioration was defined as ≥ 2 points increase of National Institutes of Health Stroke Scale (NIHSS) from baseline to 24 h, without known causes. Hypoperfusion lesions in different territories were identified on perfusion maps. Results A total of 306 patients were included in analysis. Patients with pure lenticulostriate arteries hypoperfusion (defined as the presence of hypoperfusion in lenticulostriate artery territory, but not in middle cerebral artery terminal branch territory) were more likely to have unexplained early neurological deterioration than others (27.6% vs. 6.1%; OR, 5.974; p = 0.001), after adjusting for age, baseline NIHSS and onset to treatment time. Conclusions Patients presenting hypoperfusion in pure lenticulostriate arteries territory were easier to experience unexplained early neurological deterioration.
Computed tomography perfusion as a predictor of delayed cerebral ischemia and functional outcome in spontaneous subarachnoid hemorrhage: A single center experience
Authors: Fragata Isabel , Alves Marta , Papoila Ana Luísa , Nunes Ana Paiva , Ferreira Patrícia , Diogo Mariana , Canto-Moreira Nuno , Canhão Patrícia 
Published: February 2019

Background Computed tomography (CT) perfusion has been studied as a tool to predict delayed cerebral ischemia (DCI) and clinical outcome in spontaneous subarachnoid hemorrhage (SAH). The purpose of the study was to determine whether quantitative CT perfusion performed within 72 hours after admission can predict the occurrence of DCI and clinical outcome as measured with a modified Rankin scale (mRS) at 3 months after ictus. Methods Cerebral perfusion was assessed in a prospective cohort of patients with acute SAH. CT perfusion parameters at <72 h post SAH were quantitatively measured in the main vascular territories and represented as whole-brain means. Spearman rank correlation coefficient and generalized additive regression models for binary outcome were used. Results A total of 66 patients underwent CT perfusion at <72 h. Poor clinical grade on admission was correlated with worse cerebral perfusion in all parameters. Multivariable analysis yielded an association of time to peak (TTP; odds ratio (OR) = 0.89; 95% confidence interval (CI): 0.77, 1.02; p = 0.083) with the occurrence of DCI. We also found an association of TTP values with poor outcome, with an 8% increase in the odds of mRS > 3 for each one second increase in TTP at admission (OR = 1.08; 95% CI: 1.00, 1.17; p = 0.061). Conclusions We identified an association of early TTP changes with DCI and poor clinical outcome. However, there were no associations with cerebral blood flow or mean transit time and DCI/clinical outcome. CT perfusion still remains to be validated as a tool in predicting outcome in SAH.
A radiologist’s approach to CT KUB for the urologist
Authors: Coates James D.C. , Wilkinson Christopher T.L. 
Published: February 2019

In this article we review the computed tomography imaging features of renal and ureteric calculi, the secondary signs of renal tract calculi and their possible complications. Most calculi appear as high-density foci due to their composition, whereas other signs that may be appreciated include the soft-tissue rim sign in the ureter, upstream renal tract dilation and peri-ureteric or peri-renal stranding. The most accurate means of measuring a calculus is in the coronal plane on bone windows. We also provide a systematic approach to interrogating computed tomography of the kidneys, ureter and bladder for the urologist, with examples of other conditions that may present as renal colic and are apparent on computed tomography. Level of evidence: Not applicable as no original research is being proffered.
A 2-Year Cost Analysis of Maximum Nonoperative Treatments in Patients With Symptomatic Lumbar Stenosis or Spondylolisthesis That Ultimately Required Surgery
Authors: Adogwa Owoicho , Davison Mark A. , Lilly Daniel T. , Vuong Victoria D. , Desai Shyam A. , Moreno Jessica , Cheng Joseph , Bagley Carlos 
Published: February 2019

Study Design: Retrospective cohort study. Objectives: The purpose of this study is to characterize the utilization and costs of maximal nonoperative therapies (MNTs) within 2 years prior to spinal fusion surgery in patients with symptomatic lumbar stenosis or spondylolisthesis. Methods: A large insurance database was queried for patients with symptomatic lumbar stenosis or spondylolisthesis undergoing index 1-, 2-, or 3-level lumbar decompression and fusion procedures between 2007 and 2016. This database consists of 20.9 million covered lives and includes private/commercially insured and Medicare Advantage beneficiaries. The utilization of MNTs within 2 years prior to index surgery was assessed by cost billed to the patient, prescriptions written, and number of units billed. Results: A total of 27 877 out of 3 423 114 (0.8%) eligible patients underwent posterior lumbar instrumented fusion. Patient MNT utilization was as follows: 11 383 (40.8%) used nonsteroidal anti-inflammatory drugs (NSAIDs), 19 770 (70.9%) used opioids, 12 414 (44.5%) used muscle relaxants, 14 422 (51.7%) received lumbar epidural steroid injection (LESI), 11 156 (40.0%) attended physical therapy/occupational therapy, 4005 (14.4%) presented to the emergency department, and 4042 (14.5%) received chiropractor treatments. The total direct cost associated with all MNTs prior to index spinal fusion was $28 241 320 ($1013.07 per/patient). LESI comprised the largest portion of the total cost of MNT ($15 296 941, 54.2%), followed by opioids ($3 702 463, 13.1%) and NSAIDs ($3 058 335, 10.8%). Conclusions: Opioids are the most frequently prescribed and most used therapy in the preoperative period. Assuming minimal improvement in pain and functional disability after maximum nonoperative therapies, the incremental cost effectiveness ratio for MNT could be highly unfavorable.
Should the patella be everted during primary total knee arthroplasty? A systematic review of overlapping meta-analyses
Authors: Grassi Alberto , Compagnoni Riccardo , Ferrua Paolo , Pasqualotto Stefano , Zaolino Carlo , Zaffagnini Stefano , Randelli Pietro 
Published: February 2019

Patellar eversion during total knee arthroplasty (TKA) is a debated issue. The aim of this study is to perform a review of overlapping meta-analyses analyzing clinical outcomes of patellar eversion compared to noneversion. A search was performed in PubMed\MEDLINE, Scopus, and Cochrane Library. Inclusion criteria were meta-analysis of randomized controlled trials (RCTs) or quasi-RCTs;l comparison between TKAs with or without patellar eversion; and at least one outcome, such as reoperation rate, pain, and functional scores. Meta-analyses were evaluated with the A Measurement Tool to Assess Systematic Review (AMSTAR) score, addressing the most relevant one with the Jadad algorithm. Three meta-analyses were identified and included in this review. No significant differences were found regarding complications, quadriceps strength, functional, and radiological outcomes. The meta-analysis by Zan et al. was selected as the best available one. Patellar eversion group showed a shorter tourniquet time but a longer skin incision. In conclusion, eversion and noneversion techniques did not demonstrate any significant or clinically relevant difference. Level of Evidence: Level II, systematic review of meta-analyses
Who Needs What? Perceptions of Patients and Caregivers in Oncology Phase 1 Trials
Authors: Rezash Victoria , Reed Janice , Gedeon Barbara , Parsons Eric , Siedlecki Sandra , Daniels Bradley , Shepard Dale R 
Published: February 2019

Background: The study design and nature of oncology phase 1 clinical trials create a uniquely vulnerable patient population yet little research has been conducted to identify the added burden these trials create for both cancer patients and their caregiver(s). Objective: Examining the perceptions and needs of patients and their caregivers participating in phase 1 oncology clinical trials, the investigators tested the hypothesis that the caregiver will exhibit a higher level of burden and/or distress than the patient. Method: A mixed-methods exploratory process utilizing patient and caregiver interviews and quality-of-life questionnaires was used to assess the psychosocial burdens associated with oncology clinical trial participation. A qualitative and quantitative analysis of the responses were 8 performed. Result: Both patients and caregivers reported similar themes identifying the burdens and benefits related to phase 1 clinical trial participation. However, the caregivers’ expressed burden exceeded that of the patients’ validating the study’s hypothesis. Conclusion: The need for ongoing additional support services for not only the patient but also the caregiver was identified.
Study protocol for a pragmatic trial of the Consult for Addiction Treatment and Care in Hospitals (CATCH) model for engaging patients in opioid use disorder treatment
Authors: McNeely Jennifer , Troxel Andrea B. , Kunins Hillary V. , Shelley Donna , Lee Joshua D. , Walley Alexander , Weinstein Zoe M. , Billings John , Davis Nichola J. , Marcello Roopa Kalyanaraman , Schackman Bruce R. , Barron Charles , Bergmann Luke 
Published: February 2019

Abstract
Background
Treatment for opioid use disorder (OUD) is highly effective, yet it remains dramatically underutilized. Individuals with OUD have disproportionately high rates of hospitalization and low rates of addiction treatment. Hospital-based addiction consult services offer a potential solution by using multidisciplinary teams to evaluate patients, initiate medication for addiction treatment (MAT) in the hospital, and connect patients to post-discharge care. We are studying the effectiveness of an addiction consult model [Consult for Addiction Treatment and Care in Hospitals (CATCH)] as a strategy for engaging patients with OUD in treatment as the program rolls out in the largest municipal hospital system in the US. The primary aim is to evaluate the effectiveness of CATCH in increasing post-discharge initiation and engagement in MAT. Secondary aims are to assess treatment retention, frequency of acute care utilization and overdose deaths and their associated costs, and implementation outcomes.

Methods
A pragmatic trial at six hospitals, conducted in collaboration with the municipal hospital system and department of health, will be implemented to study the CATCH intervention. Guided by the RE-AIM evaluation framework, this hybrid effectiveness-implementation study (Type 1) focuses primarily on effectiveness and also measures implementation outcomes to inform the intervention’s adoption and sustainability. A stepped-wedge cluster randomized trial design will determine the impact of CATCH on treatment outcomes in comparison to usual care for a control period, followed by a 12-month intervention period and a 6- to 18-month maintenance period at each hospital. A mixed methods approach will primarily utilize administrative data to measure outcomes, while interviews and focus groups with staff and patients will provide additional information on implementation fidelity and barriers to delivering MAT to patients with OUD.

Discussion
Because of their great potential to reduce the negative health and economic consequences of untreated OUD, addiction consult models are proliferating in response to the opioid epidemic, despite the absence of a strong evidence base. This study will provide the first known rigorous evaluation of an addiction consult model in a large multi-site trial and promises to generate knowledge that can rapidly transform practice and inform the potential for widespread dissemination of these services.
Trial registration: NCT03611335
Clinical Characteristics and Treatment Outcomes of Patients With Advanced Germ Cell Tumor Treated at a Tertiary Cancer Center in Brazil
Authors: Vasconcellos Vitor Fiorin , Bastos Diogo Assed , Pereira Allan A. Lima , Watarai Gabriel Yoshiyuki , Pereira Bruno Rodriguez , de Godoy Adriana , Almeida-Silva Jamile , Muniz David Queiroz Borges , Guglielmetti Giuliano Betoni , Nahas William Carlos , Dzik Carlos 
Published: February 2019

PURPOSE Reported treatment outcomes for patients with advanced germ cell tumors (aGCT) are based mainly on series from developed nations. Data from low- and middle-income countries are underrepresented. MATERIAL AND METHODS From 2000 to 2015, a retrospective analysis identified 300 patients with aGCT treated at our institution. Kaplan-Meier methods were used for analysis of progression-free survival (PFS) and overall survival (OS) according to the International Germ Cell Consensus Classification Group (IGCCCG). RESULTS Patients’ median age was 28 years. According to the IGCCCG, 57% had good-, 18.3% intermediate-, and 24.7% poor-risk disease. Median α-fetoprotein levels were 2.9, 243, and 3,998 ng/mL, and those of human chorionic gonadotropin were 0.4, 113, and 301.5 mUI/mL in IGCCCG good-, intermediate-, and poor-risk groups, respectively. At a median 46 months of follow-up, 93 PFS events and 45 deaths had occurred and estimated 5-year PFS and OS were 69% and 85%, respectively, including 83% and 95.3% in good-risk, 70.9% and 83.6% in intermediate-risk, and 35.1% and 62.2% in poor-risk patients, respectively. In multivariable analysis, Eastern Cooperative Oncology Group performance status ≥ 2 was a significant independent prognostic factor with a hazard ratio of 2.58 (95% CI, 1.55 to 4.29; P < .001) and 6.20 (95% CI, 2.97 to 12.92; P < .001) for PFS and OS, respectively. CONCLUSION Brazilian patients with aGCT in this cohort had similar outcomes as patients in the IGCCCG database. In comparison with contemporary series, patients with intermediate- and poor-risk aGCT had slightly inferior PFS and OS, possibly due to a high percentage of patients with poor performance status and less use of high-dose chemotherapy.
Tau modulates Schwann cell proliferation, migration and differentiation following peripheral nerve injury
Authors: Yi Sheng , Liu Qianyan , Wang Xinghui , Qian Tianmei , Wang Hongkui , Zha Guangbin , Yu Jun , Wang Pan , Gu Xiaosong , Chu Dandan , Li Shiying 
Published: February 2019

ABSTRACT
Tau protein (encoded by the gene microtubule-associated protein tau, Mapt) is essential for the assembly and stability of microtubule and the functional maintenance of the nervous system. Tau is highly abundant in neurons and is detectable in astrocytes and oligodendrocytes. However, whether tau is present in Schwann cells, the unique glial cells in the peripheral nervous system, is unclear. Here, we investigated the presence of tau and its coding mRNA, Mapt, in cultured Schwann cells and find that tau is present in these cells. Gene silencing of Mapt promoted Schwann cell proliferation and inhibited Schwann cell migration and differentiation. In vivo application of Mapt siRNA suppressed the migration of Schwann cells after sciatic nerve injury. Consistent with this, Mapt-knockout mice showed elevated proliferation and reduced migration of Schwann cells. Rats injected with Mapt siRNA and Mapt-knockout mice also exhibited impaired myelin and lipid debris clearance. The expression and distribution of the cytoskeleton proteins α-tubulin and F-actin were also disrupted in these animals. These findings demonstrate the existence and biological effects of tau in Schwann cells, and expand our understanding of the function of tau in the nervous system.
Arp2/3-branched actin regulates microtubule acetylation levels and affects mitochondrial distribution
Authors: Shi Peng , Wang Yuan , Huang Yuxing , Zhang Chunlei , Li Ying , Liu Yaoping , Li Tingting , Wang Wei , Liang Xin , Wu Congying 
Published: February 2019

ABSTRACT
Actin and microtubule cytoskeletons regulate cell morphology, participate in organelle trafficking and function in response to diverse environmental cues. Precise spatial-temporal coordination between these two cytoskeletons is essential for cells to live and move. Here, we report a novel crosstalk between actin and microtubules, in which the branched actin maintains microtubule organization, dynamics and stability by affecting tubulin acetylation levels. We observed that acetylated tubulin significantly decreases upon perturbation of the Arp2/3-branched actin. We subsequently discover that HDAC6 participates in this process by altering its interaction with tubulin and the Arp2/3-stabilizer cortactin. We further identify that the homeostasis of branched actin controls mitochondrial distribution via this microtubule acetylation-dependent mechanism. Our findings shed new light on the integral view of cytoskeletal networks, highlighting post-translational modification as another possible form of cytoskeletal inter-regulation, aside from the established crosstalks through structural connection or upstream signaling pathways.