bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial analysis of urban material stock with clustering algorithms: A Northern European case study
Authors: Gontia Paul , Thuvander Liane , Ebrahimi Babak , Vinas Victor , Rosado Leonardo , Wallbaum Holger 
Published: September 2019

AbstractA large share of construction material stock (MS) accumulates in urban built environments. To attain a more sustainable use of resources, knowledge about the spatial distribution of urban MS is needed. In this article, an innovative spatial analysis approach to urban MS is proposed. Within this scope, MS indicators are defined at neighborhood level and clustered with k‐mean algorithms. The MS is estimated bottom‐up with (a) material‐intensity coefficients and (b) spatial data for three built environment components: buildings, road transportation, and pipes, using seven material categories. The city of Gothenburg, Sweden is used as a case study. Moreover, being the first case study in Northern Europe, the results are explored through various aspects (material composition, age distribution, material density), and, finally, contrasted on a per capita basis with other studies worldwide.The stock is estimated at circa 84 million metric tons. Buildings account for 73% of the stock, road transport 26%, and pipes 1%. Mineral‐binding materials take the largest share of the stock, followed by aggregates, brick, asphalt, steel, and wood. Per capita, the MS is estimated at 153 metric tons; 62 metric tons are residential, which, in an international context, is a medium estimate. Denser neighborhoods with a mix of nonresidential and residential buildings have a lower proportion of MS in roads and pipes than low‐density single‐family residential neighborhoods. Furthermore, single‐family residential neighborhoods cluster in mixed‐age classes and show the largest content of wood. Multifamily buildings cluster in three distinct age classes, and each represent a specific material composition of brick, mineral binding, and steel. Future work should focus on megacities and contrasting multiple urban areas and, methodologically, should concentrate on algorithms, MS indicators, and spatial divisions of urban stock.
The retromer protein ZmVPS29 regulates maize kernel morphology likely through an auxin‐dependent process(es)
Authors: Chen Lin , Li Yong‐Xiang , Li Chunhui , Shi Yunsu , Song Yanchun , Zhang Dengfeng , Wang Haiyang , Li Yu , Wang Tianyu 
Published: September 2019

SummaryKernel size and morphology are two important yield‐determining traits in maize, but their molecular and genetic mechanisms are poorly characterized. Here, we identified a major QTL, qKM4.08, which explains approximately 24.20% of the kernel morphology variance in a recombinant population derived from two elite maize inbred lines, Huangzaosi (HZS, round kernel) and LV28 (slender kernel). Positional cloning and transgenic analysis revealed that qKM4.08 encodes ZmVPS29, a retromer complex component. Compared with the ZmVPS29 HZS allele, the ZmVPS29 LV28 allele showed higher expression in developing kernels. Overexpression of ZmVPS29 conferred a slender kernel morphology and increased the yield per plant in different maize genetic backgrounds. Sequence analysis revealed that ZmVPS29 has been under purifying selection during maize domestication. Association analyses identified two significant kernel morphology‐associated polymorphic sites in the ZmVPS29 promoter region that were significantly enriched in modern maize breeding lines. Further study showed that ZmVPS29 increased auxin accumulation during early kernel development by enhancing auxin biosynthesis and transport and reducing auxin degradation and thereby improved kernel development. Our results suggest that ZmVPS29 regulates kernel morphology, most likely through an auxin‐dependent process(es).
Obsessive–Compulsive Disorder and Suicidal Experiences: The Role of Experiential Avoidance
Authors: Angelakis Ioannis , Gooding Patricia 
Published: September 2019

ObjectiveObsessive–compulsive disorder (OCD) is a disabling mental health problem that affects a significant proportion of the general population. Experiential avoidance appears to account for the development of anxiety and depressive symptoms. However, its relationship with OCD has yielded contradictory results. Furthermore, although OCD‐specific thoughts and behaviors, including obsessing, checking, washing, and ordering, have been suggested to significantly predict suicidal ideation and behaviors, this line of research has received scant empirical attention. The overarching aim of this study was to explore the relationship between OCD, OCD‐specific behaviors, experiential avoidance, and suicidal experiences.MethodsOverall, 1,046 adults from the community who completed self‐report scales participated.ResultsStrong links between overall OCD severity, obsessing, experiential avoidance, and suicidal experiences were established. Results from mediational analyses showed that overall OCD severity and individual obsessive–compulsive thoughts and behaviors were both directly and indirectly linked with suicidal experiences, via experiential avoidance. Obsessing was among the critical obsessive–compulsive symptoms leading to suicidal experiences.ConclusionsThese findings are important because they identify experiential avoidance as a potential key explanatory construct in accounting for the development of OCD and suicidal experiences. However, future research using longitudinal and/or experimental designs is needed to infer causality.
Acute body sodium depletion induces skin sodium mobilization in female Wistar rats
Authors: Lopes‐Menezes V. C. , Dos‐Santos R. C. , Felintro V. , Monteiro L. R. N. , Paes‐Leme B. , Lustrino D. , Casartelli E. A. , Vivas L. , Mecawi A. S. , Reis L. C. 
Published: September 2019

New Findings
What is the central question of this study?
Can Na+ depletion mobilize Na+ from the skin reservoir in ovariectomized rats? Does oestrogen replacement change the amount and the dynamics of skin Na+ storage? Is the reduced salt appetite after Na+ depletion in ovariectomized rats with oestrogen replacement related to changes in the skin Na+?

What is the main finding and its importance?
This work demonstrated that acute body Na+ depletion induced by frusemide mobilized the osmotically inactive skin Na+ reservoir to become osmotically active. Oestrogen treatment decreased the induced Na+ intake in ovariectomized rats but did not modulate the inactive Na+ reservoir in control conditions or its mobilization induced by Na+ depletion.

AbstractOestradiol, which is an important hormone for water and electrolyte balance, also has a role in the inhibition of induced Na+ appetite. Sodium can be stored in the skin in osmotically active or inactive forms, and this skin Na+ reservoir may be involved in the control of body Na+ levels during physiopathological challenges. In this study, we investigated whether the effect of sodium depletion by frusemide can mobilize Na+ from the skin reservoir and whether oestradiol replacement changes or mobilizes the Na+ reserves in the skin. Ovariectomized Wistar rats were treated with vehicle or oestradiol for 7 days to evaluate the effects of oestrogen on the hydroelectrolyte balance, intake responses and skin Na+ and water content in basal conditions. Furthermore, the effects of oestrogen were evaluated after 24 h frusemide‐induced whole‐body Na+ depletion. Oestradiol‐replaced rats exhibited reduced water intake without any significant changes in salt intake, Na+ excretion or water and Na+ skin content in basal conditions. After sodium depletion, both vehicle‐ and oestradiol‐treated rats exhibited an increase in the osmotically active skin Na+, which was associated with a decrease of the inactive skin Na+ reservoir. Oestrogen decreased the hypertonic saline intake induced by Na+ depletion, but it was not associated with any significant changes in the skin Na+ reservoir. Thus, sodium depletion is able to change the inactive–active skin Na+ reservoir balance. However, the oestrogenic modulation of sodium appetite after Na+ depletion is probably not related to the action of this hormone in the skin Na+ reservoir balance.
Regional-scale paleobathymetry controlled location, but not magnitude, of tidal dynamics in the Late Cretaceous Western Interior Seaway, USA
Authors: Dean Christopher D. , Collins Daniel S. , van Cappelle Marijn , Avdis Alexandros , Hampson Gary J. 
Published: September 2019

Abstract
Despite extensive outcrop and previous sedimentologic study, the role of tidal processes along sandy, wave- and river-dominated shorelines of the North American Cretaceous Western Interior Seaway remains uncertain, particularly for the extensive mid-Campanian (ca. 75–77.5 Ma) tidal deposits of Utah and Colorado, USA. Herein, paleotidal modeling, paleogeographic reconstructions, and interpretations of depositional process regimes are combined to evaluate the regional-scale (hundreds to thousands of kilometers) basin physiographic controls on tidal range and currents along these regressive shorelines in the “Utah Bight”, southwestern Western Interior Seaway. Paleotidal modeling using a global and astronomically forced tidal model, combined with paleobathymetric sensitivity tests, indicates the location of stratigraphic units preserving pronounced tidal influence only when the seaway had a deep center (∼400 m) and southern entrance (>100 m). Maximum tidal velocity vectors under these conditions suggest a dominant southeasterly ebb tide within the Utah Bight, consistent with the location and orientation of paleocurrent measurements in regressive, tide-influenced deltaic units. The modeled deep paleobathymetry increased tidal inflow into the basin and enhanced local-scale (tens to hundreds of kilometers) resonance effects in the Utah Bight, where an amphidromic cell was located. However, the preservation of bidirectional, mudstone-draped cross-stratification in fine- to medium-grained sandstones requires tides in combination with fluvial currents and/or local tidal amplification below the maximum resolution of model meshes (∼10 km). These findings suggest that while regional-scale controls govern tidal potential within basins, localized physiography exerts an important control on the preservation of tidal signatures in the geologic record.
Mercury evidence of intense volcanic effects on land during the Permian-Triassic transition
Authors: Shen Jun , Yu Jianxin , Chen Jiubin , Algeo Thomas J. , Xu Guozhen , Feng Qinglai , Shi Xiao , Planavsky Noah J. , Shu Wenchao , Xie Shucheng 
Published: September 2019

Abstract
The Siberian Traps large igneous province (STLIP) was the likely trigger for the ca. 252 Ma latest Permian mass extinction (LPME), but direct evidence for global volcanic effects on land remains rare. Here, we used mercury (Hg) enrichments, a proxy for ancient volcanic activity, to assess volcanic inputs to two terrestrial Permian-Triassic boundary (PTB) sections that were separated by thousands of kilometers and represent different latitudinal zones—the peri-equatorial Lubei section (South China craton) and the high-latitude (40–60°N) Dalongkou section (Junggar terrane). Both sections exhibit strong Hg enrichment within a discrete (≤40 m) stratigraphic window representing the LPME. At Lubei, this interval is also characterized by negative mass-independent fractionation (MIF) of odd Hg isotopes, consistent with massive volcanogenic and/or terrestrial Hg inputs. These findings are significant in documenting Hg spikes and negative MIF excursions near the PTB in terrestrial sections for the first time, providing evidence of the global influence of the STLIP, as well as in demonstrating at high stratigraphic resolution its synchronicity with the PTB negative carbon-isotope excursion (CIE), supporting a common global cause for these anomalies.
Quality of medical products for diabetes management: a systematic review
Authors: Saraswati Kartika , Sichanh Chanvilay , Newton Paul N , Caillet Céline 
Published: September 2019

BackgroundThe global prevalence of diabetes mellitus is increasing alarmingly. However, the quality of vital medicines and medical products used to treat and monitor diabetes remains uncertain but of potential great public health significance. Here, we review the available evidence on the quality of antidiabetic medicines and supplies for self-monitoring of blood glucose (SMBG) and discuss their potential impact for the patients and society.MethodsSearches were conducted in PubMed, Embase, Google Scholar, Google and relevant websites in English and French. The Medicine Quality Assessment Reporting Guideline (MEDQUARG) was used to assess the quality of medicine quality surveys.Results52 publications on the quality of antidiabetic medicines, including 5 medicine quality prevalence surveys and 20 equivalence studies, were analysed. The prevalence surveys and equivalence studies included 674 samples of which 73 (10.8%) were of poor quality. The median (Q1–Q3) concordance with MEDQUARG items was 30.8% (19.2%–42.3%). No prevalence surveys on SMBG supplies’ quality were found, but 29 publications, including falsified products and incorrect results due to strip degradation or contamination, were identified.ConclusionThere is little accessible evidence on the quality of antidiabetic medicines and SMBG supplies. Surveys were poorly designed and reported, making data aggregation and interpretation problematic. Despite these caveats, these results suggest that there are important issues with the quality of medical products for diabetes that need focused monitoring. There is an urgent need to achieve consensus protocols for designing, conducting and reporting medical product quality surveys.PROSPERO registration numberCRD42016039841.
Long-term follow-up of normal and structural heart ventricular tachycardia catheter ablation: real-world experience from a UK tertiary centre
Authors: Adlan Ahmed M , Arujuna Aruna , Dowd Rory , Hayat Sajad , Panikker Sandeep , Foster Will , Yusuf Shamil , Umar Fraz , Lellouche Nicolas , Osman Faizel , Dhanjal Tarvinder 
Published: September 2019

BackgroundVentricular tachycardia (VT) is associated with increased morbidity and mortality. There is growing evidence for the effectiveness of catheter ablation in improving outcomes in patients with recurrent VT. Consequently the threshold for referral for VT ablation has fallen over recent years, resulting in increased number of procedures.ObjectiveTo evaluate the effectiveness and safety of VT ablation in a real-world tertiary centre setting.MethodsThis is a prospective analysis of all VT ablation cases performed at University Hospital Coventry. Follow-up data were obtained from review of electronic medical records and patient interview. The primary endpoint for normal heart VT was death, cardiovascular hospitalisation and VT recurrence, and for structural heart VT was arrhythmic death, VT storm (>3 episodes within 24 hours) or appropriate shock.ResultsForty-seven patients underwent 53 procedures from January 2012 to January 2018. The mean age ±SD was 57±15 years, 68% were male, 81% were Caucasian and 66% were elective cases. The aetiology of VT included normal heart (49%), ischaemic cardiomyopathy (ICM, 36%), dilated cardiomyopathy (9%), hypertrophic cardiomyopathy (4%) and valvular heart disease (2%). Procedural success occurred in 83%, with six major complications. After a median follow-up of 231 days (lower quartile 133, upper quartile 631), the primary outcome occurred in 28% of patients. There were two non-arrhythmic deaths (4%). At a median follow-up of 193 days (129–468), the primary outcome occurred in 19% of patients with ICM, while VT storm/appropriate shocks occurred in three patients (17%).ConclusionsOur real-world registry confirms that VT ablation is safe, and is associated with high acute procedural success and long-term outcomes comparable with randomised controlled studies.
Assessing differential responders and mean changes in muscle size, strength, and the crossover effect to 2 distinct resistance training protocols
Authors: Dankel Scott J. , Bell Zachary W. , Spitz Robert W. , Wong Vickie , Viana Ricardo B. , Chatakondi Raksha N. , Buckner Samuel L. , Jessee Matthew B. , Mattocks Kevin T. , Mouser J. Grant , Abe Takashi , Loenneke Jeremy P. 
Published: September 2019

The objective of this study was to determine differences in 2 distinct resistance training protocols and if true variability can be detected after accounting for random error. Individuals (n = 151) were randomly assigned to 1 of 3 groups: (i) a traditional exercise group performing 4 sets to failure; (ii) a group performing a 1-repetition maximum (1RM) test; and (iii) a time-matched nonexercise control group. Both exercise groups performed 18 sessions of elbow flexion exercise over 6 weeks. While both training groups increased 1RM strength similarly (∼2.4 kg), true variability was only present in the traditional exercise group (true variability = 1.80 kg). Only the 1RM group increased untrained arm 1RM strength (1.5 kg), while only the traditional group increased ultrasound measured muscle thickness (∼0.23 cm). Despite these mean increases, no true variability was present for untrained arm strength or muscle hypertrophy in either training group. In conclusion, these findings demonstrate the importance of taking into consideration the magnitude of random error when classifying differential responders, as many studies may be classifying high and low responders as those who have the greatest amount of random error present. Additionally, our mean results demonstrate that strength is largely driven by task specificity, and the crossover effect of strength may be load dependent. Novelty Many studies examining differential responders to exercise do not account for random error. True variability was present in 1RM strength gains, but the variability in muscle hypertrophy and isokinetic strength changes could not be distinguished from random error. The crossover effect of strength may differ based on the protocol employed.
A Neuropilin-1 Antagonist Exerts Antitumor Immunity by Inhibiting the Suppressive Function of Intratumoral Regulatory T Cells
Authors: Jung Keunok , Kim Jeong-Ah , Kim Ye-Jin , Lee Hyun Woo , Kim Chul-Ho , Haam Seokjin , Kim Yong-Sung 
Published: September 2019

Abstract
Regulatory T cells (Treg) are targeted for cancer immunotherapy because they suppress antitumor immunity. Although the importance of neuropilin-1 (NRP1) in the stability and function of intratumoral Tregs is well-documented, targeting of NRP1+ Tregs for anticancer immunotherapy has not been well explored. Here, we found that an NRP1 antagonist [Fc(AAG)-TPP11], generated by fusion of the NRP1-specific binding peptide TPP11 with the C-terminus of an effector function–deficient immunoglobulin Fc(AAG) variant, inhibits intratumoral NRP1+ Treg function and stability. Fc(AAG)-TPP11 triggered the internalization of NRP1, reducing its surface expression on Tregs and thereby inhibiting the suppressive function of Tregs. In two murine syngeneic tumor models, Fc(AAG)-TPP11 retarded tumor growth, comparable with a Treg-depleting anti–CTLA-4 antibody, without noticeable toxicity. Fc(AAG)-TPP11 inhibited NRP1-dependent Treg function, inducing unstable intratumoral Tregs, with reduced expression of Foxp3 and enhanced production of IFNγ, which subsequently increased the functionality and frequency of intratumoral CD8+ T cells. We also observed selective expression of NRP1 on Tregs isolated from human tumors, but not from the blood of healthy donors and patients with cancer, as well as ex vivo inhibition of intratumoral NRP1+ Treg function by Fc(AAG)-TPP11. Our results suggest that the NRP1 antagonist Fc(AAG)-TPP11 has therapeutic potential for the inhibition of intratumoral NRP1+ Tregs with limited unfavorable effects on peripheral Tregs.
Heterogeneity in neutrophil responses to immune complexes
Authors: Duarte Madelaine , Kuchibhatla Maragatha , Khandelwal Sanjay , Arepally Gowthami M. , Lee Grace M. 
Published: September 2019

Key PointsIn a whole blood assay, ICs cause neutrophil activation and degranulation. Individuals have a fixed susceptibility to neutrophil activation by ICs.
Developing a system dynamics model for prediction of phosphorus in facultative stabilization ponds
Authors: Shahsavani Ebrahim , Ebrahimi Ali Asghar , Ehrampoush Mohammad Hassan , Maleknia Houshang , Eslami Hadi , Samaei Mohammad Reza 
Published: September 2019

AbstractSystem dynamics is considered as a computer-aided approach to policy analysis and design. It includes the response and reaction of a system to external shocks. In the present research, following the sampling and testing phases, a system dynamics model was developed for modeling of phosphorus in facultative stabilization ponds. First, the scheme of soluble reactive phosphorous stock, its specifications and parameters were determined and created in the VenSim PLE 7.1 software. Then, mathematical relations were determined for each process. Finally, the model was calibrated and verified based on the data from the Yazd facultative ponds, Iran. Sensitivity analysis showed that the most important factors affecting phosphorus concentration in the ponds are the phosphorus settling rate, losses caused by algal respiration and excretion, while the losses caused by herbivorous zooplanktons, hydrolysis rate of inorganic carbon, and ratio of phosphorus to chlorophyll-a had the least importance. Results showed that, algal growth rate and phosphorus settling rate were important factors in phosphorus removal. Hence, with appropriate retention time in the pond, it can be managed more properly. The ratio of phosphorus to algae had less importance in the model. The ratio of carbon to phosphorus and rate of respiration of carnivorous zooplanktons did not affect the phosphorus concentration. It is recommended that this model can be used for pond management and overall assessment of facultative ponds.
Evaluating temperature-induced regulation of a ROSE-like RNA-thermometer for heterologous rhamnolipid production in Pseudomonas putida KT2440
Authors: Noll Philipp , Treinen Chantal , Müller Sven , Senkalla Sabine , Lilge Lars , Hausmann Rudolf , Henkel Marius 
Published: September 2019

AbstractThe microbial production of rhamnolipids has been in the focus of research for the last decades. Today, mainly heterologous production systems are targeted due to the advantage of non-pathogenic hosts as well as uncoupling from complex quorum sensing regulatory networks compared to their natural producerPseudomonas aeruginosa. In the recent past, the presence and function of a ROSE-like RNA-thermometer located in the 5′UTR of the rhamnosyltransferase genesrhlABhas been reported in wild typeP. aeruginosa. In this study, the temperature-induced regulation of this native RNA-thermometer for heterologous rhamnolipid production was evaluated and its potential application for process control is discussed. For this purpose, the non-pathogenic production hostP. putidaKT2440 containing therhlABgenes with the nativeP. aeruginosa5′-UTR region was used. The system was evaluated and characterized regarding the effect of temperature on growth and product formation, as represented by efficiency parameters and yields. Experimental data suggests a major effect of temperature on specific rhamnolipid production rates. With maximum values of 0.23 g/(g h) at 37 °C, this constitutes a more than 60% increase compared to the production rate of 0.14 g/(g h) at the growth optimum of 30 °C. Interestingly however, control experiments unveiled that besides the regulatory effect of the RNA-thermometer, multiple metabolic effects may contribute equally to the observed increase in production rate. As such, this work constitutes an important step towards the utilization of temperature-based process designs and enables the possibility for novel approaches for process control.