bluuebunny/crossref_metadata_2025_split huggingface dataset:
Применение ВЭЖХ совместно с оптическими и термическими методами в комплексном анализе межкомпонентных взаимодействий фармацевтических композиций
Authors: Eltsova Natalia O. , Budko Elena V. 
Published: October 2019

Разнообразие новых лекарственных препаратов и возрастающие требования применяемого к ним стандарта качества требуют систематического подхода к исследованию возможного взаимодействия компонентов. Комплексное применение оптических, хроматографических и термоаналитических методов в сочетании с воздействием стресс-факторов позволило исследовать процессы и дать характеристику продуктов деструкции. По результатам опыта работы с группой многокомпонентных препаратов анальгетического, противовоспалительного и противопростудного действия сформулирован единый методический подход к процессу изучения стабильности фармацевтических субстанций всоставе лекарственных композиций.
TÜRKİYE VE AMERİKA’DA DRAMATİK YAZARLIK EĞİTİM PROGRAMLARININ KARŞILAŞTIRMALI OLARAK İNCELENMESİ
Authors: Belkıs Özlem , Gümüş Yunus Emre , Şaşmaz Hatice , Alpan Ezgi Deniz 
Published: October 2019

Oyun yazarlığı 2500 yılık bir tarihe
sahiptir, fakat ilgili akademik eğitimin tarihi ancak 100 yıllıktır. Lisans
düzeyindeki ilk dramatik yazarlık dersleri 1905’te Harvard Üniversitesi’nde,
1925’te Yale Üniversitesi’nde verilmiştir. Ardından farklı üniversitelerde
çeşitli kademelerde dramatik yazarlık eğitimi yaygınlaşmıştır. Türkiye’de ise
ilk oyun yazarlığı eğitimi 1964’te Ankara Üniversitesi’nde, 1976’da Ege
Üniversitesi’nde başlamış, bugün yedi üniversitede
sürdürülmektedir. Türkiye’de dramatik yazarlık eğitimi programlarının
değerlendirilmesi ve geliştirilmesi için öneriler üretilmesi
bağlamında bir çalışma bulunmamaktadır. Bununla birlikte yurt içi ile yurt
dışındaki eğitim programlarını karşılaştırılmalı olarak ele alan bir araştırmaya
da alan yazın taraması sonucunda rastlanmamıştır. Bir bilim alanında yürütülen
eğitim programlarının geliştirilebilmesi için farklı programların kapsamlarını
incelemek, tartışmaya açmak önemli ve gereklidir. Bu yönüyle araştırmamızın
alan yazına katkı sağlayacağına inanılmaktadır. Bu araştırmanın amacı,
Türkiye’de ve ABD’de sürdürülen dramatik yazarlık/oyun yazarlığı eğitim
programlarının karşılaştırılmalı olarak incelenmesidir. Araştırmanın kapsamını,
Türkiye’de ve ABD’de dramatik yazarlık eğitimini aktif olarak sürdüren üniversitelerin
2018-2019 eğitim/öğretim yılı verileri oluşturmaktadır. ABD, dramatik yazarlık
eğitiminin lisans düzeyinde verilmeye başlandığı ilk ülke olduğu için
seçilmiştir. Bu çalışma bir profil çıkarma çalışmasıdır ve yöntem olarak
karşılaştırmalı eğitim araştırmalarında kullanılan yatay yaklaşım benimsenmiş,
nitel araştırma yöntemlerinden doküman inceleme uygulanmış, farklılıklar
program seviyesi, kontenjanları, giriş ve mezuniyet koşulları, zorunlu ve
seçmeli dersler bağlamında sunulmuştur
Factores que inciden en la aceptabilidad de la vasectomía
Authors: Meneses-Parra Angy-Lorena , Cristancho-Gómez Sandra-Milena 
Published: October 2019

La vasectomía es un procedimiento que genera mínimas complicaciones y ostenta una tasa de éxito del 99 %; además tiene menor costo que la esterilización femenina, por lo cual se debe tener en cuenta el rol que desempeña el hombre en el número de hijos que se proyecta tener. En esta revisión de tema se identificaron los factores que inciden en la aceptabilidad de la vasectomía. Se realizó la búsqueda de la literatura en las bases de datos de PubMed, ProQuest, BioMed Central, ScienceDirect y Clinical Key para el periodo 2008-2017. Se seleccionaron 39 artículos por haber cumplido los criterios de inclusión: (a) publicado entre el 2008 y el 2017, en inglés, español o portugués y b) reportar resultados afines al tema de interés con evidencia de calidad científica durante la aplicación de las listas de chequeo. La sistematización y análisis de la información permitió la construcción de tres categorías temáticas: Entorno cultural, Condiciones sociales y Educación e información. Sobre la temática se evidenció que los factores como las creencias, el entorno sociocultural y la educación e información que tienen los hombres y sus parejas sobre la vasectomía influyen en la decisión de realizarse o no este procedimiento. Un hallazgo novedoso fue que el sexo de la descendencia también incide en esta decisión. Se recomienda una educación masiva para aumentar el acceso y conocimiento de la vasectomía.
Percepciones de adolescentes sobre los derechos sexuales y reproductivos que favorecen la prevención del embarazo en esta etapa
Authors: Vanegas-de-Ahogado Blanca-Cecilia , Pabón-Gamboa Marcela , Plata-de-Silva Rita-Cecilia 
Published: October 2019

Objetivo: describir la percepción de un grupo de adolescentes acerca de los derechos sexuales y reproductivos que favorecen la prevención de la maternidad y la paternidad en esta etapa. Método: estudio cualitativo fenomenológico. La información se recogió con 20 adolescentes escolarizados a través de grupos focales. Análisis mediante codificación abierta, conformación de categorías y su descripción. Resultados: limitaciones en el conocimiento sobre concepto de derechos sexuales y reproductivos porque los asocian exclusivamente con relaciones sexuales; las preguntas que guiaron el desarrollo de los grupos focales facilitaron discusión y expresión de su percepción sobre el tema de estudio. Conclusiones: los participantes perciben el derecho a fortalecer la autoestima como fundamental para prevenir maternidad y paternidad en la adolescencia porque: proporciona seguridad en sí mismo; favorece tomar decisiones de tener o no relaciones sexuales y anticonceptivos; disminuye probabilidad de dejarse presionar para tener relaciones sexuales, y facilita informar si está siendo presionado al respecto. Enfatizan importancia de promover autoestima en mujeres porque son quienes reciben mayor presión o presentan mayor riesgo de violación sexual. Recibir información sobre sexualidad y reproducción proporciona conocimientos que facilitan toma de decisiones para prevenir maternidad y paternidad; la información que reciben no es suficiente porque existen muchos tabúes de progenitores, quienes restringen este derecho por temor a estimular inicio de relaciones sexuales tempranas. Priorizan derecho a recibir servicios de salud para anticonceptivos porque previenen embarazos en adolescentes. Obstáculos para ejercer este derecho: desconocer tema/lugar para adquirirlos; limitaciones económicas; miedo de ser descubierto y ser juzgados.
Factores psico-socio-ambientales asociados al estrés laboral en profesores chilenos del ámbito rural y urbano
Authors: Rubio-González Juan , Andrade Daigre Paula , Fravega Araneda Gabriela , Macalusso Salgado Soledad , Soto Sandoval Andrés 
Published: October 2019

<p>El objetivo de este estudio fue indagar acerca de las percepciones que tienen los profesores de colegios urbanos y rurales sobre los factores psico-socio-ambientales desencadenantes del estrés laboral docente. Considerando un enfoque cualitativo fenomenológico, con alcance exploratorio, se utiliza un diseño de estudio de casos con docentes de la localidad de Collipulli, sur de Chile, con técnica de Grupo de Discusión para recabar datos, y análisis de contenido de los mismos, del que se desprende que los profesores tienden a percibir que factores ambientales tales como liderazgos deficientes, roles docentes desconfigurados, agobio laboral, sumado a aulas sobrepobladas, alumnos desmotivados, y desvinculación de los padres de su rol educativo, serían las principales amenazas para su salud mental. Se discute sobre los recursos psicológicos, estilos de afrontamiento y percepción del contexto que presentan los profesores del estudio.</p>
Tecnoestrés docente y percepción de la calidad de servicio en una universidad privada de Lima
Authors: Alcas Zapata Noel , Alarcón Diaz Henry Hugo , Venturo Orbegoso Carlos Oswaldo , Alarcón Diaz Mitchell Alberto , Fuentes Esparrell Juan Antonio , López Echevarria Tatiana Isabel 
Published: October 2019

<p>El presente estudio tiene como objetivo conocer la asociación existente entre el tecnoestrés docente y la percepción de la calidad de servicio al interior de una universidad peruana. Las perturbaciones psicofisiológicas que podrían estar provocando los medios tecnológicos al entrar en contacto con los trabajadores son analizadas como parte del impacto de las nuevas tecnologías en los espacios laborales. En tal sentido, se llevó a cabo una investigación cuantitativa y no experimental en la que se recolectaron datos mediante la aplicación de dos instrumentos: el Cuestionario Red (2004) el cual contiene 16 ítems vinculado al tecnoestrés y el Modelo ServQual con 22 ítems el cual midió la percepción de la calidad de servicio. Ambos instrumentos pasaron la prueba de confiabilidad a través del coeficiente de Alfa de Cronbach obteniendo un valor de ,891 y ,911, respectivamente. A través de un muestreo probabilístico se consideró como muestra a 154 docentes. Para el análisis estadístico descriptivo e inferencial, se generaron tablas de contingencia, utilizando el estadístico de prueba Chi-Cuadrado de Pearson, a partir del cual se concluye que existe asociación entre el Tecnoestrés docente y la percepción de la calidad de servicio (<em>X<sup>2</sup> </em>(6) = 85,731 y la Sig. Asintótica (bilateral) o p_valor = 0.000 &lt; 0.05). Asimismo, se concluye que existe asociación entre el Tecnoestrés docente y las percepciones de cada de las dimensiones teóricas de la calidad de servicio: elementos tangibles (<em>X<sup>2</sup> </em>(6) = 112,055 y la Sig. Asintótica (bilateral) o p_valor = 0.000 &lt; 0.05), fiabilidad (<em>X<sup>2</sup> </em>(6) = 63,859 y la Sig. Asintótica (bilateral) o p_valor = 0.000 &lt; 0.05), capacidad de respuesta (<em>X<sup>2</sup> </em>(6) = 35,580 y la Sig. Asintótica (bilateral) o p_valor = 0.000 &lt; 0.05), seguridad (<em>X<sup>2</sup> </em>(6)<em> </em>= 42,838 y la Sig. Asintótica (bilateral) o p_valor = 0.000 &lt; 0,05) y la empatía (<em>X<sup>2</sup> </em>(6)<em> </em>= 23,633, con seis grados de libertad (6) y la Sig. Asintótica (bilateral) o p_valor = 0.000 &lt; 0.05).</p>
Identification of Students Misconception Using Two-Tier Diagnostic Test Completed with Certainty of Response Index (CRI) on Topic Partial Salt Hydrolysis
Authors: Putro Tomas Istantyo , Ariani Sri Retno Dwi , Yamtinah Sri 
Published: October 2019

<p>This study’s aim was to find misconception pattern on partial salt hydrolysis on eleventh grade student science major at SMA Negeri 2 Sukoharjo. Misconception was identified using two-tier diagnostic test completed with CRI supported by observation on learning process also interview. Two-tier diagnostic test composed of 16 questions. The approach of this study was qualitative description which was held in February-June 2018. The subject of this study were the eleventh grade students class IPA 1 and IPA 4 as many as 72 students. According to the result showed that there was misconception on almost every concept’s part. Based on the student answer analysis result shows if the pH, relative atomic mass, and volume were known student were having biggest misconception on counting salt’s mass are, 75%. The reason of misconception that occurs on partial salt hydrolysis is come from the student it self that is student’s uncomplete reasoning pattern.</p>
College Students and SNAP: The New Face of Food Insecurity in the United States
Authors: Freudenberg Nicholas , Goldrick-Rab Sara , Poppendieck Janet 
Published: October 2019

Over the last decade, multiple studies of food insecurity among college students have found rates from 20% to more than 50%, considerably higher than the 12% rate for the entire US population. Reasons for higher rates of food insecurity among college students include a growing population of low-income college students, high college costs and insufficient financial aid, more financial hardship among many low- and moderate-income families, a weak labor market for part-time workers, declining per capita college resources, and Supplemental Nutritional Assistance Program (SNAP) policies that specifically exclude many college students from participation. This essay reviews the causes and consequences of food insecurity on campus, explores reasons for the low SNAP participation rate, and describes how campuses have responded to food insecurity. It summarizes federal, state, and local changes in SNAP policies that can facilitate college student participation and retention and suggests strategies for more robust and effective university responses to food insecurity, including SNAP enrollment campaigns, a stronger role for campus food services, and a redefinition of the goals and purposes of campus food pantries.
Importance of the Supplemental Nutrition Assistance Program in Rural America
Authors: Harnack Lisa , Valluri Sruthi , French Simone A. 
Published: October 2019

There is great interest in reshaping the Supplemental Nutrition Assistance Program (SNAP) so that it better supports family nutrition, and an array of program changes have been proposed. We note the importance of considering the unique needs of rural SNAP participants when considering and implementing these changes. We also describe the SNAP-related needs and challenges unique to rural SNAP participants, and through this lens we discuss changes to SNAP that have been proposed and special considerations related to each. The special considerations we identified include allowing canned, frozen, and dried fruits and vegetables as eligible items in financial incentive programs in rural areas; changing direct education programming to address transportation-related barriers many rural families face in attending in-person classes; and supporting rigorous research to evaluate the potential benefits and unintended consequences of proposed program changes for which scant high-quality evaluation data exist. Evaluation studies should include rural SNAP participants so that effects in this important population group are known.
O ESTÁGIO CURRICULAR OBRIGATÓRIO COMO POSSIBILIDADE DE RESSIGNIFICAR A PRÁTICA DOCENTE: APRENDIZAGEM DE FUNÇÕES DE 1º GRAU NO ENSINO FUNDAMENTAL
Authors: Araujo Iris Tuty Dalcanale , Catafesta Simone , Oliveira Fátima Peres Zago de , Hoeller Solange Aparecida de Oliveira , Piehowiak Ruy 
Published: October 2019

Esse trabalho apresenta relato da experiência do Estágio Supervisionado II, do Curso de Matemática-Licenciatura do Instituto Federal Catarinense – Câmpus Rio do Sul, realizado na Escola de Educação Básica Paulo Zimmermann de Rio do Sul/SC, em uma turma de 8ª série do Ensino Fundamental, de julho a agosto de 2012. O objetivo do estágio foi aplicar os saberes/conhecimentos adquiridos na formação acadêmica, relacionando teoria e prática, enquanto que o objetivo relacionado ao conteúdo foi o aprendizado dos alunos sobre função de 1º grau. As etapas metodológicas aplicadas foram: diferenciação de equação, expressão e função, plano cartesiano, conceitos e construção de gráficos, com pesquisa e levantamento de dados extraclasse e avaliação. Desse modo, o contexto abordado permitiu a compreensão de propostas que podem auxiliar professores e alunos a compreenderem melhor o conceito, características e aplicações de funções, enfatizando a importância de trabalhar temas relacionados à realidade do aluno, contextualizados e possibilitando a interpretação dos conceitos matemáticos.
Implementation Strategy and Cost of Mozambique’s HPV vaccine demonstration project
Authors: Soi Caroline , Babigumira Joseph B. , Chilundo Baltazar , Muchanga Vasco , Matsinhe Luisa , Gimbel Sarah , Augusto Orvalho , Sherr Kenneth 
Published: October 2019

Abstract
Background Cost is as an important determinant of health program implementation. In this study, we conducted a comprehensive evaluation of the implementation strategy of Mozambique’s school-based HPV vaccine demonstration project. We sought to estimate the total cost of the program and the cost per fully immunized girl (FIG), and to project the total cost of implementing a similar immunization program at the national level. Methods We collected primary data through document review, participatory observation, and key informant interviews with project implementers at the central offices of the national immunization program, provincial and district health directorates, and in health facilities. We used a combination of micro-costing methods— the identification and measurement of resources quantities and valuation by application of unit costs, and gross costing—the consideration of resource bundles as they apply to the number of FIGs. We extrapolated the cost per FIG to the HPV-vaccine-eligible population of Mozambique under current guidelines to demonstrate the projected total annual cost for a similarly executed HPV vaccine program. Results The total cost of the Mozambique HPV vaccine demonstration project was $523,601. The mean cost per FIG was $72 (95% CI: $62 - $83) in year one, $38 (95% CI: $37 - $40) in year two, and $54 (95% CI: $49 - $61) for years one and two. The mean cost per FIG with the third HPV vaccine dose excluded from implementation was $60 (95% CI: $50 - $72) in year one, $38 (95%CI: $31 - $46) in year two, and $48 (95%CI: $42 - $55) for years one and two. The projected annual cost of a two-dose vaccine program targeting all 10-year-old girls in the country was $18,156,549 ($15,865,384 - $20,748,196). The main cost drivers in the analysis were vaccine price, number of doses administered per recipient, program startup costs, and the costs of demand creation. Conclusion National adaptation and scale-up of Mozambique’s school-based HPV vaccine strategy would result in substantial costs. To achieve national-level HPV vaccine roll out and sustainability, stakeholders will need to negotiate vaccine prices and achieve better efficiency in startup activities and demand creation.
Stakeholder views on the acceptability of Human Infection Studies in Malawi
Authors: Kapumba Blessings M. , Jambo Kondwani , Rylance Jamie , Gmeiner Markus , Sambakunsi Rodrick , Parker Michael , Gordon Stephen B. , Gooding Kate 
Published: October 2019

Abstract
Background: Human infection studies (HIS) are valuable in vaccine development. Deliberate infection, however, creates challenging questions, particularly in low and middle-income countries (LMIC) where HIS are new and ethical challenges may be heightened. Consultation with stakeholders is needed to support contextually appropriate and acceptable study design. We examined stakeholder perceptions about the acceptability and ethics of HIS in Malawi, to inform decisions about planned pneumococcal challenge research and wider understanding of HIS ethics in LMIC.
Methods: We conducted 6 deliberative focus groups and 15 follow-up interviews with research staff, medical students, and community representatives from rural and urban Blantyre. We also conducted 5 key informant interviews with clinicians, ethics committee members and district health government officials.
Findings: Stakeholders perceived HIS research to have potential population health benefits, but they also had concerns, particularly related to safety of volunteers and negative community reactions. Acceptability depended on a range of conditions related to procedures for voluntary and informed consent, inclusion criteria, medical care or support, compensation, regulation, and robust community engagement. These conditions largely mirror those in existing guidelines for HIS and biomedical research in LMICs. Stakeholder perceptions pointed to potential tensions, for example balancing equity, safety and relevance in inclusion criteria.
Conclusions: Our findings suggest HIS research could be acceptable in Malawi, provided certain conditions are in place. Ongoing assessment of participant experiences and stakeholder perceptions will be required to strengthen HIS research during development and roll-out.
Key words: Human Infection Studies, pneumococcal, Malawi, acceptability, ethics
Changes in Determinants and Equity of Family Planning Utilization after the Implementation of a National Health Insurance Policy in Indonesia: A Secondary Analysis of The 2012-2016 National Socio-Economic Survey of Indonesia
Authors: Nasution Siti Khadijah , Mahendradhata Yodi , Trisnantoro Laksono 
Published: October 2019

Abstract
Background: The Indonesian government has been implementing the National Health Insurance Policy (Jaminan Kesehatan Nasional-JKN) since 2014. The utilization of family planning service is one of the programs to increase maternal and child health status that is included in the benefit package in JKN. This study aimed to describe determinants and to evaluate JKN based on equity indicators, especially in family planning services.
Methods: Data were obtained from the 2012-2016 National Socio-Economic Survey (SUSENAS) of Indonesia. Contraceptive Prevalence Rate (CPR) and Long-acting contraceptives (LACs) use were used as indicators to evaluate family planning utilization. Chi-square and logistic regression tests were used to analyze the data. Respondents were married women between 15 and 49 years of age.
Results: There was no progress in CPR after the implementation of JKN. At the national level, CPR decreased within five years (2012-2016). Decreasing in urban areas and in the group that does not have health insurance were more than in rural areas and in the group that has health insurance. Utilization of non-LACs, especially injection (56%-57%) and pill (21%-24%), were still high within 2012-2016. At the national level, LACs use increased 3.18% between 2012-2016 (15.54%-18.72%). Increasing in urban areas and in the group that has subsidized health insurance were more than in rural areas and in the group that does not have subsidized. In 2016, the geography factor (rural-urban) and household economic status associated negatively with the use of overall contraceptive method (p<0.05). Conversely, all the determinants were positively associated with LACs use (p<0.05).
Conclusions: Up to 2016, the JKN program did not increase CPR. Conversely, the JKN program obtained only small increases in LACs use. LACs use in rural areas is less than in urban areas. JKN program can increase LACs use in the group that has subsidized health insurance. CPR and LACs coverage could increase through health system improvement, and the societal norms approach. Health system improvement is operationalized through improving supply-side and regulations, increasing coordination among multiple agencies in the family planning program.
Keywords: Equity, National Health Insurance, Family Planning, Indonesia
Cytokeratin 7-Negative and GATA Binding Protein 3-Negative Breast Cancers: Clinicopathological Features and Prognostic Significance
Authors: Lu Shaolei , Yakirevich Evgeny , Wang Li Juan , Resnick Murray B , Wang Yihong 
Published: October 2019

Abstract
Cytokeratin 7 (CK7) and GATA binding protein 3 (GATA3) are considered as immunohistochemical hallmarks of breast cancers; however, there are breast tumors lacking these markers. Clinicopathological characterization of CK7 negative breast cancer has not been addressed previously and similar studies on GATA3 negative tumors are limited. This study included 196 consecutive cases of Nottingham Grade 3 breast cancers with 159 cases of Grade 1 and Grade 2 tumors for comparison. CK7 and GATA3 expression was correlated with patient’s age, histological type, pathological grade and stage, hormone receptor status, molecular subtype and overall survival. CK7 negativity was seen in 13% of Grade 3, 9% of Grade 2, and 2% of Grade 1 cases (P=0.0457). Similarly, 28% of Grade 3, 5% of Grade 2 and 2 % of Grade 1 cases were GATA3 negative (P<0.0001). CK7 negative tumors did not show association with other clinicopathological parameters. GATA3 negative tumors were enriched in the basal-like molecular subgroup and were associated with negative estrogen receptor (ER) and negative progesterone receptor (PR) statuses. Both CK7 and GATA3 expression showed no association with overall survival in patients with Grade 3 tumor. This is the first study to characterize CK7 negative breast tumors in the context of clinicopathology.