bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiC
Authors: Liu Qixiao , Chen Zhifeng , Yu Zhibin 
Published: April 2019

Graphics processing units (GPUs)
1
have enjoyed increasing popularity in recent years, which benefits from, for example, general-purpose GPU (GPGPU) for parallel programs and new computing paradigms, such as the Internet of Things (IoT). GPUs hold great potential in providing effective solutions for big data analytics while the demands for processing large quantities of data in real time are also increasing. However, the pervasive presence of GPUs on mobile devices presents great challenges for GPGPU, mainly because GPGPU integrates a large amount of processor arrays and concurrent executing threads (up to hundreds of thousands). In particular, the root causes of performance loss in a GPGPU program can not be revealed in detail by current approaches.

In this article, we propose MiC (Multi-level Characterization), a framework that comprehensively characterizes GPGPU kernels at the instruction, Basic Block (BBL), and thread levels. Specifically, we devise Instruction Vectors (IV) and Basic Blocks Vectors (BBV), a Thread Similarity Matrix (TSM), and a Divergence Flow Statistics Graph (DFSG) to profile information in each level. We use MiC to provide insights into GPGPU kernels through the characterizations of 34 kernels from popular GPGPU benchmark suites such as Compute Unified Device Architecture (CUDA) Software Development Kit (SDK), Rodinia, and Parboil. In comparison with Central Processing Unit (CPU) workloads, we conclude the key findings as follows: (1) There are comparable Instruction-Level Parallelism (ILP); (2) The BBL count is significantly smaller than CPU workloads—only 22.8 on average; (3) The dynamic instruction count per thread varies from dozens to tens of thousands and it is extremely small compared to CPU benchmarks; (4) The Pareto principle (also called 90/10 rule) does not apply to GPGPU kernels while it pervasively exists in CPU programs; (5) The loop patterns are dramatically different from those in CPU workloads; (6) The branch ratio is lower than that of CPU programs but higher than pure GPU workloads. In addition, we have also shown how TSM and DFSG are used to characterize the branch divergence in a visual way, to enable the analysis of thread behavior in GPGPU programs. In addition, we show an optimization case for a GPGPU kernel from the bottleneck identified through its characterization result, which improves 16.8% performance.
Client-side Computational Optimization
Authors: Maniezzo Vittorio , Boschetti Marco A. , Carbonaro Antonella , Marzolla Moreno , Strappaveccia Francesco 
Published: April 2019

Mobile platforms have matured to a point where they can provide the infrastructure required to support sophisticated optimization codes. This opens the possibility to envisage new interest for distributed application codes and the opportunity to intensify research on optimization algorithms requiring limited computational resources, as provided by mobile platforms.
In this article, we report on some exploratory experience in this area. We illustrate some practical, real-world cases where running optimization programs on mobile or embedded devices can be useful, with particular emphasis on matheuristics approaches. Then, we discuss a practical use case involving the feasibility version of the generalized assignment problem (GAP). We present a JavaScript implementation of a GAP solver that can be executed inside an ordinary browser supporting ECMAScript. We tested the code on different smartphones of varying age and power, as well as on desktop PCs and other embedded devices. Our experiments confirm the viability of mobile devices for computational intensive tasks.
MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation
Authors: Hansen Landon J. , Sun Ran , Yang Rui , Singh Simranjit X. , Chen Lee H. , Pirozzi Christopher J. , Moure Casey J. , Hemphill Carlee , Carpenter Austin B. , Healy Patrick , Ruger Ryan C. , Chen Chin-Pu J. , Greer Paula K. , Zhao Fangping , Spasojevic Ivan , Grenier Carole , Huang Zhiqing , Murphy Susan K. , McLendon Roger E. , Friedman Henry S. , Friedman Allan H. , Herndon James E. , Sampson John H. , Keir Stephen T. , Bigner Darell D. , Yan Hai , He Yiping 
Published: April 2019

Abstract

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic alterations in glioblastoma (GBM), but its pathologic consequences remain unclear. In this study, we report that loss of MTAP results in profound epigenetic reprogramming characterized by hypomethylation of PROM1/CD133–associated stem cell regulatory pathways. MTAP deficiency promotes glioma stem-like cell (GSC) formation with increased expression of PROM1/CD133 and enhanced tumorigenicity of GBM cells and is associated with poor prognosis in patients with GBM. As a combined consequence of purine production deficiency in MTAP-null GBM and the critical dependence of GSCs on purines, the enriched subset of CD133+ cells in MTAP-null GBM can be effectively depleted by inhibition of de novo purine synthesis. These findings suggest that MTAP loss promotes the pathogenesis of GBM by shaping the epigenetic landscape and stemness of GBM cells while simultaneously providing a unique opportunity for GBM therapeutics.

Significance:
This study links the frequently mutated metabolic enzyme MTAP to dysregulated epigenetics and cancer cell stemness and establishes MTAP status as a factor for consideration in characterizing GBM and developing therapeutic strategies.
LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma
Authors: Galan-Cobo Ana , Sitthideatphaiboon Piyada , Qu Xiao , Poteete Alissa , Pisegna Marlese A. , Tong Pan , Chen Pei-Hsuan , Boroughs Lindsey K. , Rodriguez Mirna L.M. , Zhang Winter , Parlati Francesco , Wang Jing , Gandhi Varsha , Skoulidis Ferdinandos , DeBerardinis Ralph J. , Minna John D. , Heymach John V. 
Published: April 2019

Abstract

In KRAS-mutant lung adenocarcinoma, tumors with LKB1 loss (KL) are highly enriched for concurrent KEAP1 mutations, which activate the KEAP1/NRF2 pathway (KLK). Here, we investigated the biological consequences of these cooccurring alterations and explored whether they conferred specific therapeutic vulnerabilities. Compared with KL tumors, KLK tumors exhibited increased expression of genes involved in glutamine metabolism, the tricarboxylic acid cycle, and the redox homeostasis signature. Using isogenic pairs with knockdown or overexpression of LKB1, KEAP1, and NRF2, we found that LKB1 loss results in increased energetic and redox stress marked by increased levels of intracellular reactive oxygen species and decreased levels of ATP, NADPH/NADP+ ratio, and glutathione. Activation of the KEAP1/NRF2 axis in LKB1-deficient cells enhanced cell survival and played a critical role in the maintenance of energetic and redox homeostasis in a glutamine-dependent manner. LKB1 and the KEAP1/NRF2 pathways cooperatively drove metabolic reprogramming and enhanced sensitivity to the glutaminase inhibitor CB-839 in vitro and in vivo. Overall, these findings elucidate the adaptive advantage provided by KEAP1/NRF2 pathway activation in KL tumors and support clinical testing of glutaminase inhibitor in subsets of KRAS-mutant lung adenocarcinoma.

Significance:
In KRAS-mutant non–small cell lung cancer, LKB1 loss results in enhanced energetic/redox stress, which is tolerated, in part, through cooccurring KEAP1/NRF2–dependent metabolic adaptations, thus enhancing glutamine dependence and vulnerability to glutaminase inhibition.
Super-Mini Percutaneous Nephrolithotomy Reduces the Incidence of Postoperative Adverse Events in Pediatric Patients: A Retrospective Cohort Study
Authors: Yuan Dongbo , Zhang Wei , Zhan Xiong , Su Jiaming , Wang Wei , Luan Boshi , Xiao Shiwei , Chen Weihong , Sun Zhaolin , An Nini , Zhu Jianguo 
Published: April 2019

<b><i>Objective:</i></b> To assess the safety of the super-mini percutaneous nephrolithotomy (SMP) versus the minimally invasive percutaneous nephrolithotomy (MPCNL) in the treatment of pediatric renal calculus. <b><i>Methods:</i></b> We retrospectively reviewed the electronic records of pediatric patients who underwent treatment for renal stones by either SMP or MPCNL from May 2015 to May 2016. We compared the safety of the 2 surgical procedures in the treatment of renal calculus in children by using the generalized estimating equation (GEE) multivariate regression analysis, in which the exposures are the surgical procedures and postoperative adverse events (postoperative complications, fever, and WBC counts) are set as outcome variables. <b><i>Results:</i></b> The study included 39 patients (26 boys and 13 girls), of which 22 underwent MPCNL and 17 underwent SMP, with a mean age of 110.05 ± 45.01 and 93.18 ± 41.72 months, respectively. In the univariate logistic regression model, the surgical procedures showed no significant association with postoperative complications (95% CI 0.0–1.5), fever (95% CI 0.1–2.1), postoperative peripheral WBC (95% CI 0.1–2.2). In the multiple logistic regression analysis, there was an insignificant association between surgical methods and postoperative complications (95% CI 0.28–1.1), fever (95% CI 0.1–1.2), and postoperative peripheral WBC (95% CI 0.03–1.8). While using GEE with multiple dependent variables and MPCNL as a reference, the OR of adverse events was 0.15 and the 95% CI were 0.04–0.55. <b><i>Conclusions:</i></b> Compared to MPCNL, SMP has a lower incidence of postoperative complications and appears to be a safer treatment for children with kidney stones.
Identifying the Infarct-Related Artery in Patients With Non–ST-Segment–Elevation Myocardial Infarction
Authors: Heitner John F. , Senthilkumar Annamalai , Harrison J. Kevin , Klem Igor , Sketch Michael H. , Ivanov Alexandr , Hamo Carine , Van Assche Lowie , White James , Washam Jeffrey , Patel Manesh R. , Bekkers Sebastiaan C.A.M. , Smulders Martijn W. , Sacchi Terrence J. , Kim Raymond J. 
Published: April 2019

Background:
Determining the infarct-related artery (IRA) in non–ST-segment–elevation myocardial infarction (MI) can be challenging. Delayed-enhancement cardiac magnetic resonance (DE-CMR) can accurately identify small MIs. The purpose of this study was to determine whether DE-CMR improves the ability to identify the IRA in patients with non–ST-segment–elevation MI.

Methods and Results:
In this 3-center, prospective study, we enrolled 114 patients presenting with their first MI. Patients underwent DE-CMR followed by coronary angiography. The interventional cardiologist was blinded to the DE-CMR results. Later, coronary angiography and DE-CMR images were reviewed independently and blindly for identification of the IRA. The pattern of DE-CMR hyperenhancement was also used to determine whether there was a nonischemic pathogenesis for myocardial necrosis. The IRA was not identifiable by coronary angiography in 37% of patients (n=42). In these, the IRA or a new noncoronary artery disease diagnosis was identified by DE-CMR in 60% and 19% of patients, respectively. Even in patients with an IRA determined by coronary angiography, a different IRA or a noncoronary artery disease diagnosis was identified by DE-CMR in 14% and 13%, respectively. Overall, DE-CMR led to a new IRA diagnosis in 31%, a diagnosis of nonischemic pathogenesis in 15%, or either in 46% (95% CI, 37%–55%) of patients. Of 55 patients undergoing revascularization, 27% had revascularization solely to nonculprit coronary artery territories as determined by DE-CMR.

Conclusions:
Identification of the IRA by coronary angiography can be challenging in patients with non–ST-segment–elevation MI. In nearly half, DE-CMR may lead to a new IRA diagnosis or elucidate a nonischemic pathogenesis. Revascularization solely of coronary arteries that are believed to be nonculprit arteries by DE-CMR is not uncommon.
Predictors of quality of life among community psychiatric patients in a peri-urban district of Gauteng Province, South Africa
Authors: Mapatwana Dumakazi , Tomita Andrew , Burns Jonathan K , Robertson Lesley J 
Published: April 2019

Background: Few studies on quality of life (QoL) among people with mental illness have been conducted in South Africa, and none in community dwelling individuals. However, a greater understanding of subjective QoL may inform community-based medical, psychotherapeutic, or social interventions. This study examined the QoL, clinical and sociodemographic characteristics of psychiatric patients attending community mental health clinics in the Gauteng Province of South Africa. Methods: A cross sectional interview-based study was conducted with 121 adult patients attending community psychiatric clinics. To reduce the impact of acute psychiatric symptoms on subjective QoL, only clinically stable patients were included. Sociodemographic details and clinical characteristics were recorded. Subjective QoL was assessed using the World Health Organization QOL-Bref scale (WHOQOL-Bref), and severity of psychiatric illness measured with the Brief Psychiatric Rating Scale, expanded version 4.0 (BPRS-E). Results: Just over half of the sample rated their overall QoL as good or very good. Residual psychiatric symptomatology was the strongest predictor of a poor QoL in all four domains of the WHOQOL-Bref. The most severe BPRS scores were for the symptoms of depression, anxiety and somatic concern. Perceived social support significantly predicted a better QoL in the psychological, social relationships and environmental domains. Conclusion: This study highlights the negative impact of residual psychiatric symptoms on subjective QoL and the importance of social support in enhancing QoL.
Cost-efficacy of Knee Cartilage Defect Treatments in the United States
Authors: Everhart Joshua S. , Campbell Andrew B. , Abouljoud Moneer M. , Kirven J. Caid , Flanigan David C. 
Published: April 2019

Background: Multiple knee cartilage defect treatments are available in the United States, although the cost-efficacy of these therapies in various clinical scenarios is not well understood. Purpose/Hypothesis: The purpose was to determine cost-efficacy of cartilage therapies in the United States with available mid- or long-term outcomes data. The authors hypothesized that cartilage treatment strategies currently approved for commercial use in the United States will be cost-effective, as defined by a cost <$50,000 per quality-adjusted life-year over 10 years. Study Design: Systematic review. Methods: A systematic search was performed for prospective cartilage treatment outcome studies of therapies commercially available in the United States with minimum 5-year follow-up and report of pre- and posttreatment International Knee Documentation Committee subjective scores. Cost-efficacy over 10 years was determined with Markov modeling and consideration of early reoperation or revision surgery for treatment failure. Results: Twenty-two studies were included, with available outcomes data on microfracture, osteochondral autograft, osteochondral allograft (OCA), autologous chondrocyte implantation (ACI), and matrix-induced ACI. Mean improvement in International Knee Documentation Committee subjective scores at final follow-up ranged from 17.7 for microfracture of defects >3 cm2 to 36.0 for OCA of bipolar lesions. Failure rates ranged from <5% for osteochondral autograft for defects requiring 1 or 2 plugs to 46% for OCA of bipolar defects. All treatments were cost-effective over 10 years in the baseline model if costs were increased 50% or if failure rates were increased an additional 15%. However, if efficacy was decreased by a minimum clinically important amount, then ACI (periosteal cover) of femoral condylar lesions ($51,379 per quality-adjusted life-year), OCA of bipolar lesions ($66,255) or the patella ($66,975), and microfracture of defects >3 cm2 ($127,782) became cost-ineffective over 10 years. Conclusion: Currently employed treatments for knee cartilage defects in the United States are cost-effective in most clinically acceptable applications. Microfracture is not a cost-effective initial treatment of defects >3 cm2. OCA transplantation of the patella or bipolar lesions is potentially cost-ineffective and should be used judiciously.
Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears
Authors: Yonemitsu Ryuji , Tokunaga Takuya , Shukunami Chisa , Ideo Katsumasa , Arimura Hitoshi , Karasugi Tatsuki , Nakamura Eiichi , Ide Junji , Hiraki Yuji , Mizuta Hiroshi 
Published: April 2019

Background:The effects of fibroblast growth factor 2 (FGF-2) on healing after surgical repair of chronic rotator cuff (RC) tears remain unclear.Hypothesis:FGF-2 enhances tenogenic healing response, leading to biomechanical and histological improvement of repaired chronic RC tears in rats.Study Design:Controlled laboratory study.Methods:Adult male Sprague-Dawley rats (n = 117) underwent unilateral surgery to refix the supraspinatus tendon to its insertion site 3 weeks after detachment. Animals were assigned to either the FGF-2 group or a control group. The effects of FGF-2 were assessed via biomechanical tests at 3 weeks after detachment and at 6 and 12 weeks postoperatively and were assessed histologically and immunohistochemically for proliferating cell nuclear antigen and mesenchymal stem cell (MSC)–related markers at 2, 6, and 12 weeks postoperatively. The expression of tendon/enthesis-related markers, including SRY-box 9 (Sox9), scleraxis (Scx), and tenomodulin (Tnmd), were assessed by real-time reverse transcription polymerase chain reaction, in situ hybridization, and immunohistochemistry. The effect of FGF-2 on comprehensive gene expressions at the healing site was evaluated by microarray analysis.Results:The FGF-2 group showed a significant increase in mechanical strength at 6 and 12 weeks compared with control; the FGF-2 group also showed significantly higher histological scores at 12 weeks than control, indicating the presence of more mature tendon-like tissue. At 12 weeks, Scx and Tnmd expression increased significantly in the FGF-2 group, whereas no significant differences in Sox9 were found between groups over time. At 2 weeks, the percentage of positive cells expressing MSC-related markers increased in the FGF-2 group. Microarray analysis at 2 weeks after surgery showed that the expression of several growth factor genes and extracellular matrix–related genes was influenced by FGF-2 treatment.Conclusion:FGF-2 enhanced the formation of tough tendon-like tissues including an increase in Scx- or Tnmd-expressing cells at 12 weeks after surgical repair of chronic RC tears. The increase in mesenchymal progenitors and the changes in gene expression upon FGF-2 treatment in the early phase of healing appear to be related to a certain favorable microenvironment for tenogenic healing response of chronic RC tears.Clinical Relevance:These findings may provide advantages in therapeutic strategies for patients with RC tears.
Costing a Maternity Leave Cash Transfer to Support Breastfeeding Among Informally Employed Mexican Women
Authors: Vilar-Compte Mireya , Teruel Graciela , Flores Diana , Carroll Grace J. , Buccini Gabriela S. , Pérez-Escamilla Rafael 
Published: April 2019

Background: Investing in maternity protection for working women is an important social equity mechanism. Addressing the maternity leave needs of women employed in the informal sector economy should be a priority as more than half of women in Latin America, South Asia, and sub-Saharan Africa are employed in this sector. Objective: To develop a costing methodology framework to assess the financial feasibility, at the national level, of implementing a maternity cash transfer for informally employed women. Methods: A World Bank costing methodology was adapted for estimating the financial need to establish a maternity cash transfer benefit. The methodology estimates the cash transfer’s unitary cost, the incremental coverage of the policy in terms of time, the weighted population to be covered, and the administrative costs. The 6-step methodology uses employment and sociodemographic data that are available in many countries through employment and demographic surveys and the population census. The methodology was tested with data for Mexico assuming different cash transfer unitary costs and the benefit’s time coverage. Results: The methodological framework estimated that the annual financial needs of setting up a maternity cash transfer for informally working women in Mexico ranges between US$87 million and US$280 million. Conclusions: A pragmatic methodology for assessing the costs of maternity cash transfer for informally employed women was developed. In the case of Mexico, the maternity cash transfer for women in the informal sector is financially feasible.
Diagnostic yield of the Japan NBI Expert Team (JNET) classification for endoscopic diagnosis of superficial colorectal neoplasms in a large‐scale clinical practice database
Authors: Kobayashi Shunsuke , Yamada Masayoshi , Takamaru Hiroyuki , Sakamoto Taku , Matsuda Takahisa , Sekine Shigeki , Igarashi Yoshinori , Saito Yutaka 
Published: April 2019

BackgroundMagnifying Narrow Band Imaging (NBI) during colonoscopy is a reliable method for differential and depth diagnoses of colorectal lesions. This study examined the diagnostic yield of magnifying NBI based on the Japan NBI Expert Team (JNET) classification in a clinical setting using a large‐scale clinical practice database. Types 1, 2A, 2B and 3 correspond to the histopathological classifications of hyperplastic polyp/sessile‐serrated polyp, low‐grade intramucosal neoplasia, high‐grade intramucosal neoplasia/shallow submucosal invasive cancer, and deep submucosal invasive cancer, respectively.MethodsThe prospective records of colonoscopy reports and pathological data of 1558 consecutive superficial colorectal lesions removed by colonoscopy were retrospectively analysed. After excluding 156 lesions, the documented JNET classifications of the remaining 1402 colorectal lesions were analysed. Diagnostic yield was analysed and also compared between expert endoscopists and nonexpert endoscopists.ResultsThe sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were respectively 75%, 96%, 74%, 96% and 93% for type 1; 91%, 70%, 92%, 67% and 87% for type 2A; 42%, 95%, 26%, 98% and 93% for type 2B; and 35%, 100%, 93%, 98% and 98% for type 3. Nonexpert and expert endoscopists alike had specificity, NPV and accuracy >90% for types 1, 2B and 3, and a sensitivity and PPV >90% for type 2A. Type 2B had a low sensitivity of 42% because it included various histological features.ConclusionsThe JNET classification proved useful in a clinical setting both for expert and nonexpert endoscopists, as was expected from the original JNET definition, but type 2B requires further investigation using pit pattern diagnosis.