bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of dietary lecithin intake with MCI risk and cognitive performance in elderly population
Authors: Qi Chengyan , Shen Jing , Ding Huini , Li Dajun , Wang Wenjing , Fu Yuebao , Liu Yijia , Xi Yuandi , Xiao Rong 
Published: November 2024

Abstract

Background
This study aims to explore the relationship between dietary lecithin intake and cognitive function and the development and progression of Mild cognitive impairment (MCI) in the elderly over 60 years old.
Methods
The research undertaken included a cohort of 1917 participants aged over 60. Body composition was evaluated through bioelectrical impedance analysis. Cognitive function and dietary intake were assessed using neuropsychological tests and a food frequency questionnaire. Spearman correlation analysis, multiple linear regression, logistic regression, and receiver operating characteristic curves were employed to elucidate the relationship of dietary lecithin on MoCA (Montreal Cognitive Assessment) score and the risk of MCI and predictive effect.
Results
Of 1917 participants enrolled, 1023 (53.4%) had MCI and 542 (53.0%) were women. After adjusting for multiple confounders, multiple linear regression showed that after dichotomizing lecithin and serum cholesterol indicators according to the median, high levels of lecithin, TC(Total Cholesterol) and low levels of LDL-C(Low density lipoprotein cholesterol)/HDL-C(High density lipoprotein cholesterol) were associated with higher MoCA; logistic regression showed that compared with low intake level, the odds ratio (95% CI) of MCI risk in high dietary lecithin intake group was 0.80(0.64,0.99). The results of ROC curve showed that the model had a good predictive effect on MCI.
Conclusions
Higher dietary lecithin intake was associated with better performance on cognitive assessments and diminished risk of MCI among the elderly population aged 60 and above. It possesses the capabilities to function as prospective biomarkers that may indicate an increased risk of cognitive decline among the elderly demographic.
Implicit Bias in ICU Electronic Health Record Data Measurement Frequencies and Missingness Rates of Clinical Variables
Authors: Shi Junming Seraphina , Hubbard Alan E. , Fong Nicholas , Pirracchio Romain 
Published: November 2024

Abstract

Background:
Disparities in data collection within electronic health records (EHRs), especially in Intensive Care Units (ICUs), can reveal underlying biases that may affect patient outcomes. Identifying and mitigating these biases is critical for ensuring equitable healthcare. This study aims to develop an analytical framework for measurement patterns, including missingness rates and measurement frequencies, evaluate the association between them and demographic factors, and assess their impact on in-hospital mortality prediction.
Methods:
We conducted a retrospective cohort study using the Medical Information Mart for Intensive Care III (MIMIC-III) database, which includes data on over 40,000 ICU patients from Beth Israel Deaconess Medical Center (2001–2012). Adult patients with ICU stays longer than 24 hours were included. Measurement patterns, such as missingnessrates and measurement frequencies, were derived from EHR data and analyzed. Targeted Machine Learning (TML) methods were used to assess potential biases in measurement patterns across demographic factors (age, gender, race/ethnicity) while controlling for confounders such as other demographics and disease severity. The predictive power of measurement patterns on in-hospital mortality was evaluated.
Results:
Among 23,426 patients, significant demographic disparities were observed in the first 24 hours of ICU stays. Elderly patients (≥ 65 years) had more frequent temperature measurements compared to younger patients, while males had slightly fewer missing temperature measurements than females. Racial disparities were notable: White patients had more frequent blood pressure and oxygen saturation (SpO2) measurements compared to Black and Hispanic patients. Measurement patterns were associated with ICU mortality, with models based solely on these patterns achieving an area under the receiver operating characteristic curve (AUC) of 0.76 (95% CI: 0.74–0.77).
Conclusions:
This study underscores the significance of measurement patterns in ICU EHR data, which are associated with patient demographics and ICU mortality. Analyzing patterns of missing data and measurement frequencies provides valuable insights into patient monitoring practices and potential biases in healthcare delivery. Understanding these disparities is critical for improving the fairness of healthcare delivery and developing more accurate predictive models in critical care settings.
Relevance, Potentials and Success Factors of Regional Multi-Stakeholder Cooperation for Corporate Decarbonization – Evidence from German Business
Authors: Raupach-Sumiya Jörg 
Published: November 2024

Abstract

Background
A growing number of companies worldwide develop proactive strategies for climate protection. These efforts for corporate decarbonization are frequently embedded in the transformation of entire sectors and infrastructures. However, such transformative processes inevitably impact on local communities and lead to growing interdependencies between companies and multiple local stakeholders. While these interdependencies create a compelling case for regional multi-stakeholder cooperation, management-oriented research has hitherto neglected the regional dimension of multi-stakeholder cooperation and its benefits for corporate decarbonization.
Results
This research introduces a framework and taxonomy enabling us to identify suitable forms, potential areas and success factors for collaborative approaches to corporate climate protection at local level. Presenting the results of an in-depth study on German business, this paper shows that regional multi-stakeholder cooperation is increasingly recognized as a critical dimension of corporate strategies for climate protection. The acknowledged need for transformative change constitutes the overarching common purpose for such collaborative approaches. Infrastructure-related areas such as energy, mobility, or industrial and commercial district development emerge as particularly meaningful fields for regional cooperation. The study finds that a competently managed, institutionalized multi-stakeholder network; implementation-oriented joint projects; and the empowerment of regional managers to act as local change agents are the key ingredients for effective regional cooperation benefitting corporate decarbonization.
Conclusion
The study argues that regional multi-stakeholder cooperation is still a neglected but essential strategic dimension for corporate decarbonization. Effective collaborative corporate strategies for climate protection at local level require the systematic integration of this dimension into prevailing management practices, processes and tools inside their organizations. Corporate leaders need to demonstrate a strong sense of agency to champion transformative change at local level.
The virome investigation of the globally endangered Eld's deer (Rucervus eldii) on Hainan Island, China
Authors: Su Haoxiang , Zheng Dandan , Li Zihan , Qi Xuming , Chang Yunxing , Ren Guangxu , Lu Qingqing , Li Jiaqi , Li Yu , Tian Chuan , Peng Ruoyan , Wang Gaoyu , Hu Xiaoyuan , Huang Yi , Tang Chuanning , Cui Xiuji , Niu Lina , Zhao Mingming , Tan Xianghui , Dong Jie , Yang Jian , Yang Fan , Yin Feifei , Li Youyou , Lu Gang , Zhang Yun 
Published: November 2024

Abstract

More than 60% of emerging (re-emerging) infectious diseases worldwide are caused by animal-derived pathogens, of which 71% are of wild animal origin. It is important to obtain insight into the viral pathogens present in the wildlife reservoir from a public health perspective. Based on next-generation sequencing (NGS), we report a metagenomic viral survey of Eld's deer (Rucervus eldii) (n = 33) in Bangxi Provincial Nature Reserve in Hainan Province. We collected 33 nasal swabs, 33 anal swabs, and 9 tick bite wound swabs and combined them into 5 pools according to the type of swabs. The metagenomic analysis showed that there were differences in the 5pools of viral reads, but the overall viral reads were closely related to mammals. We amplified and obtained the complete genomes of novel papillomaviruses (PV) and circoviruses (CV) in Eld's deer, PsPV-HMU-1 and PsaCV-HMU-1. The novel PV and CV genomic structure revealed that it was consistent with that of the known mammalian PV and CV. The L1 of PsPV-HMU-1 and the rep of PsaCV-HMU-1 showed less than 77.20% and 45.43% amino acid homology with the closest viruses, respectively. The positive rate of PV carried by Eld's deer is relatively high. Multiple Eld's deer with positive nase or anal swabs, accompanied by positive swabs from tick bites and wounds, indicate that insect bites may be closely related viral infection. This study helps us monitor Eld's deer viral diseases and understand the genetic diversity and evolutionary history of FV and CV carried by Eld's deer.
Credit and Municipal Agricultural Production in the Northeast: a Spatial Econometric Approach
Authors: Filho Luis Abel da Silva , Alves Denis Fernandes , Barbosa Ana Claudia Felipe , Lima Maria Messias Ferreira 
Published: November 2024

Abstract

The mechanisms of reach and the expansion of credit granted to Brazilian agriculture have become determinants of production in the sector on a national scale. Thus, this study aims to analyze the effects of agricultural credit on the gross value of agricultural production (GDP) in the Northeast region. Through an exploratory analysis of spatial data and spatial econometrics, it is possible to verify the significant and positive impact of credit, both granted through the Constitutional Financing Funds and the National Development Bank (BNDES), on the GDP of agriculture in the Northeast. The Durbin Spatial Model of Error (SDEM) was estimated and chosen from the tests of Robust Lagrange Multipliers, the Moran Index of the residuals under randomization, and the Monte Carlo simulation of Moran's I. The results unequivocally demonstrate that credit, along with the amount of rainfall, the number of agricultural pieces of machinery, and the use of fertilizer in the soil, has positively impacted the agricultural GDP in the northeastern municipalities over the years analyzed. These findings have significant implications for the agricultural sector, particularly in the Northeast region, and can inform policy and practice.
Sensitive fluorescent probe for Al 3+ , Cr 3+ and Fe 3+ : application in real water samples and logic gate
Authors: Lin Ziyun , Shi Yu , Song Yanxi , Yan Jiabao , Li Hongqi , Xie Chengxiao 
Published: November 2024

Abstract

Construction of single probes for simultaneous detection of common trivalent metal ions has attracted much attention due to higher efficiency in analysis and cost. A naphthalimide-based fluorescent probe K1 was synthesized for selective detection of Al3+, Cr3+ and Fe3+ ions. Fluorescence emission intensity at 534 nm of probe K1 in DMSO/H2O (9:1, v/v) was significantly enhanced upon addition of Al3+, Cr3+ and Fe3+ ions while addition of other metal ions (Li+, Na+, K+, Ag+, Cu2+, Fe2+, Zn2+, Co2+, Ni2+, Mn2+, Sr2+, Hg2+, Ca2+, Mg2+, Ce3+, Bi3+ and Au3+) did not bring about substantial change in fluorescence emission. The calculated detection limits were 0.32 µM, 0.81 µM, and 0.27 µM for Al3+, Cr3+, and Fe3+, respectively. Probe K1 displayed strong anti-interference ability, a large Stokes shift, rapid response, and applicability in a wide pH range for the simultaneous detection of Al3+, Cr3+ and Fe3+ in real water samples. Job's plot test showed that the stoichiometric ratio of the complexes formed between probe K1 and the trivalent metal ions was 1:1. The reversible application of probe K1 was realized by addition of Na2EDTA. A molecular logic gate was built based on the input-output information. This approach may provide a basis for highly selective and sensitive detection of common trivalent cations and for design of memory devices.
Sequential infiltration of Th17 cells into the substantia nigra in a primate model of Parkinson's disease
Authors: Seo Jincheol , Nguyen Thanh Thi Hai , Won Jinyoung , Jeon Chang-Yeop , Baek Seung Ho , Park Junghyung , Seong Jung Bae , Yeo Hyeon-Gu , Kim Keonwoo , Gwon Lee Wha , Kim Minji , Kim Yu Gyeong , Lee Sang-Woo , Jung Yunkyo , Min Jisun , Choi Won Seok , Huh Jae-Won , Lim Kyung Seob , Lee Youngjeon 
Published: November 2024

Abstract

Parkinson’s disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN). Recent studies have focused on the dysregulation of CD4+ T cell subsets, including Th17 cells, with nigrostriatal dopaminergic neurodegeneration in PD. Nonetheless, the mechanisms behind the sequential and sustained infiltration of these T cell subsets into the brain during PD progression are not well understood. This study aimed to elucidate the long-term infiltration patterns of Th1, Th2, and Th17 cells in the SN during PD progression. After injecting cynomolgus monkeys with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to develop a non-human primate model of PD, we observed dopaminergic neuronal loss and infiltration patterns of CD4+ T cell subsets in the SN at early, intermediate, and late phases. Th17 cells were observed to infiltrate immediately during the early phase, unlike the delayed infiltration observed for Th1 and Th2 cells. Notably, the early phase infiltration of Th17 cells coincides with the rapid degeneration of dopaminergic neurons. Furthermore, the physical proximity between Th17 lymphocytes and a decreased number of dopaminergic neurons was observed in the SN after MPTP injection. This study reinforces that Th17 cells are associated with neurodegeneration of dopaminergic neurons in the onset of PD.
Comparative Cost Analysis for Bore Hole and Bark Streak Tapping Methods in Resin Production from Pinus brutia
Authors: Caglayan İnci , Kabak Özgür , Sarı İrem Uçal 
Published: November 2024

Abstract

This study assesses the economic and technical feasibility of two resin extraction methods, Bore Hole Tapping (BH) and Bark Streak Tapping (BS), applied to Pinus brutia in the Korudağ Forest, Turkey. Resin production from 758 trees was analyzed over six months to compare setup costs, operational expenses, labor costs, and yields. Additionally, a feasibility study involving 2500 trees was conducted to evaluate market, technical, and financial aspects. Results show that both methods incur high production costs, making resin production economically unviable under current market conditions. The BH method is particularly unfeasible due to significant initial investments and high operating costs. In contrast, the BS method, with lower costs, approaches viability at historically higher resin prices. Sensitivity analyses suggest that the BS method could become feasible with a significant rise in market prices. However, resin production from Pinus brutia remains economically unfeasible at present.
Spatio-temporal patterns of defoliation in agro-forestry Quercus ilex L. systems
Authors: González Isabel , Oliveira Nerea , Alberdi Iciar , Adame Patricia , Fuertes Alicia , Cañellas Isabel , Moreno-Fernández Daniel 
Published: November 2024

Abstract

Agroforestry systems such as oak dehesas face increased vulnerability due to the abandonment of sustainable practices, extreme droughts, and emerging pathogens. Despite the adaptability of the holm oak (Quercus ilex L.) to adverse conditions, signs of deterioration such as defoliation, reduced growth, and increased mortality have been observed in recent years. This study aims to evaluate the temporal dynamics of defoliation in Q. ilex dehesa systems distributed across western Spain. Furthermore, we aim to study the potential effects of climate and site conditions on defoliation in Q. ilex stands. Defoliation was analyzed over a 31-year period (1987–2018) in 254 monitoring plots, examining correlations with site variables (elevation, latitude, slope, orientation, soil texture, nitrogen, and carbon) and climate factors (temperature, precipitation). Average defoliation ranged from 17.9–21.5%, with northern Q. ilex dehesas in cooler, wetter regions exhibiting less defoliation than southern populations in harsher environments. Between 1987 and 1998, defoliation increased markedly across the region, especially in northern dehesas (up to an 88% rise), compared to a 40–50% increase at more favorable sites. Defoliation was negatively correlated with soil nitrogen content, latitude, and elevation, and positively correlated with clay content and average annual temperature. Therefore, the forecasted harsher climatic conditions may contribute to increased defoliation of entire populations of Q. ilex growing in dehesas. This could threaten the persistence of these agroforestry systems and the ecosystem services provided by them, especially in the southern populations.
Crystal structure of anthracen-9-yl(3,6-dimethoxynaphthalen-2-yl)methanone: Decisive factors for formation of two-fold helical molecular assemblies in three directions affording chiral crystal
Authors: Li Kun , Iitsuka Hiroaki , Tsumuki Takehiro , Noguchi Keiichi , Yonezawa Noriyuki , Okamoto Akiko 
Published: November 2024

Abstract

The titled compound of 3-(anthracen-9-carbonylated) 2,7-dimethoxynaphthalene, anthracen-9-yl(3,6-dimethoxynaphthalen-2-yl)methanone, affords as chiral crystals belonging to P212121 space group. To investigate the leading factors of chiral supramolecular crystallisation, the crystal structural characteristics of the titled compound were compared with the two homologous 3-aroylated 2,7-dimethoxynaphthalene compounds, 3-benzoylated and 3-(1-naphthoylated) derivatives, giving achiral crystals of P21/c space group, along with their mother skeleton molecule of 2,7-dimethoxynaphthalene, which also gives chiral crystals with P212121 space group. The spatial features of single molecular crystal structure, molecular accumulation fashion, non-covalent bonding interactions, and proximity of molecules in crystal have been measured among four compounds. In the crystalline single molecular structure of the titled 9-anthracenecarbonyl compound, the 2,7-dimethoxynaphthalene ring connects to the ketonic carbonyl moiety with almost perpendicular fashion and anthracene ring connects to the ketonic carbonyl moiety with a nearly coplanar alignment. On the other hand, in the crystalline single molecular structures of the benzoylated and naphthoylated homologues, the ketonic carbonyl groups connect to arene rings with moderate twist angles. In crystal packings of the benzoylated and 1-naphthoylated homologues, the centrosymmetric dimeric aggregations with pairs of complementary non-classical hydrogen bonds are observed. The titled compound is observed to form two-fold helical molecular assemblies with non-classical hydrogen bonds along a-axis. Hirshfeld surface analysis has emphasised that these packing motifs afford different effects to the molecular packing. The titled anthroylated compound has the largest number of molecules in close proximity among three compounds. The crystal structures of the four compounds including non-aroylated 2,7-dimethoxynaphthalene from the viewpoint of formation potential of chiral crystal have been interpreted by the transition of the types and ratio of the effective non-classical hydrogen bonds functioning inter- and intramolecular modes under the prior influence led by ketonic carbonyl group participating interactions.
A Source Model for Volcanic Explosions and its Influence on Lamb Wave Wavelengths: Insights from the 2022 Hunga Tonga Eruption
Authors: Ponomarev Oleg 
Published: November 2024

Abstract

Using the dimensional analysis a novel model for shock wave generation during explosive volcanic eruptions is proposed. A relationship between the parameters of the shock wave in the vicinity of the source and those of the atmospheric Lamb wave is established, offering an explanation for the phenomenon of longer-than-expected periods in volcanic Lamb waves, first observed following the 1980 eruption of Mount St. Helen's. Differences between atmospheric Lamb waves generated by volcanic explosive eruptions and thermonuclear tests are studied. Additionally, based on the proposed model, a method for estimating the composition of volcanic gases based solely on observational data from points distant from the epicenter is derived. The model's consistency with observational data is demonstrated through a comparison with barographic measurements from the January 15, 2022, Hunga-Tonga eruption, provided by Albuquerque Seismological Laboratory, where the Lamb wave was recorded at 50 stations worldwide. The evolution of Lamb wave parameters with distance and its attenuation characteristics were investigated using observational data.
Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections?
Authors: Ingham Abigail R , McSorley Stephen T , McMillan Donald C , Mansouri David , Chong David , Mackay Graham J , Wrobel Aleksandra , Kong Chia Yew , Roxburgh Campbell SD 
Published: November 2024

Abstract

Background:
Obesity (BMI > 30kg/m2) is rapidly increasing worldwide with 26% of the UK population obese and 38% overweight. Obesity is intimately related to several life-limiting conditions including colorectal cancer (CRC). Obese patients have a higher degree of perioperative systemic inflammatory response (SIR) and an increased risk of perioperative complications. The aim of this current study was to investigate whether robotic-assisted surgery mitigates the effects of obesity in left sided CRC resections on the SIR and clinical outcomes.
Methods:
All patients undergoing left-sided colorectal cancer resections from May 2021 to May 2023 were prospectively entered into a database with patient characteristics and perioperative short-term outcomes recorded. CRP was considered a surrogate for SIR. The relationship between obesity and complications were examined using Chi Square for linear association, Kruskall-Wallace for continuous data and multivariate binary logistic regression model.
Results:
221 patients who underwent RAS for left-sided CRC were analysed. Obesity was associated with more comorbidity (ASA, p < 0.01) and SSI (p < 0.05) but not with age, sex, procedure or pathology. POD3 CRP < 150mg/l was also associated with obesity (p < 0.01). In turn, greater comorbidity was associated with age (p < 0.001), site of resection (p < 0.05), SSI (p < 0.05), postoperative blood transfusion (p < 0.01) and LOS (p < 0.001). On multivariate analysis, only greater ASA (p < 0.05) and surgical procedure (p < 0.01) were associated with the development of an SSI independently.
Conclusion:
Greater comorbidity but not obesity was independently associated with postoperative SIR and clinical outcomes in patients undergoing RAS. These results support the use of RAS for left sided CRC resections, particularly in the obese.