bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microfluidics‐Implemented Biochemical Assays: From the Perspective of Readout
Authors: Chen Wenwen , Shao Fangchi , Xianyu Yunlei 
Published: September 2019

AbstractOver the past decades, microfluidics has emerged as an increasingly important tool to perform biochemical assays for diagnosis and healthcare. The precise fluid control and molecule manipulation within microfluidics greatly contribute to developing assays with simplicity and convenience. The advantages of microfluidics, including decreased consumption of reagents and samples, lower operating and analysis time, much lower cost, and higher integration and automation over traditional systems, offer a great platform to meet the needs of point‐of‐care applications. In this Review, versatile strategies are outlined and recent advances in microfluidics‐implemented assays are discussed from the perspective of readout, because a convenient and straightforward readout is what a biochemical assay requires and the end user desires. Functions and properties arising from each readout are reviewed and the advantages and limitations of each readout are discussed together with current challenges and future perspectives.
Ultrahigh Rate Performance of Hollow Antimony Nanoparticles Impregnated in Open Carbon Boxes for Sodium‐Ion Battery under Elevated Temperature
Authors: Xu Anding , Xia Qi , Zhang Shenkui , Duan Huanhuan , Yan Yurong , Wu Songping 
Published: September 2019

AbstractAntimony is a competitive and promising anode material for sodium‐ion batteries (SIBs) due to its high theoretical capacity. However, the poor rate capability and fast capacity fading greatly restrict its practical application. To address the above issues, a facile and eco‐friendly sacrificial template method is developed to synthesize hollow Sb nanoparticles impregnated in open carbon boxes (Sb HPs@OCB). The as‐obtained Sb HPs@OCB composite exhibits excellent sodium storage properties even when operated at an elevated temperature of 50 °C, delivering a robust rate capability of 345 mAh g−1 at 16 A g−1 and rendering an outstanding reversible capacity of 187 mAh g−1 at a high rate of 10 A g−1 after 300 cycles. Such superior electrochemical performance of the Sb HPs@OCB can be attributed to the comprehensive characteristics of improved kinetics derived from hollow Sb nanoparticles impregnated into 2D carbon nanowalls, the existence of robust SbOC bond, and enhanced pseudocapacitive behavior. All those factors enable Sb HPs@OCB great potential and distinct merit for large‐scale energy storage of SIBs.
Physicochemical and Functional Characterization of Potato Starch (Solanum Tuberosum ssp. Andigenum) from the Quebrada De Humahuaca, Argentina
Authors: Calliope Sonia , Wagner Jorge , Samman Norma 
Published: September 2019

AbstractThe physicochemical properties of starches of 16 Andean potato genotypes from the Quebrada de Humahuaca, Jujuy, are studied and possible applications are evaluated. Moisture, protein, ash, phosphorus, amylose/amylopectin ratio, particle size, swelling power, water absorption index, solubility index, syneresis, turbidity, thermal properties, gelatinization, retrogradation, and their corresponding enthalpies are determined. The analysis of principal components allowed obtaining groups of varieties with similar properties. Four groups of genotypes are obtained: one group is characterized by high gelatinization temperatures, so it can be used for products that require high processing temperatures; the second, with greater swelling power, can be applied in products that require water retention; other can be used in the production of edible film because it has higher amylose content which improves its mechanical properties; the latter is characterized by having a high stability and lower syneresis which indicates it is possible to use in processes that require refrigeration and freezing. The information obtained in this study can be useful for the production of potatoes with differentiated characteristics of their starches and with the possibility to be applied both in food and in non‐food products.
Does Smoking Impair Bone Regeneration in the Dental Alveolar Socket?
Authors: Shah Furqan A. , Sayardoust Shariel , Omar Omar , Thomsen Peter , Palmquist Anders 
Published: September 2019

Abstract
Smoking is a major risk factor for dental implant failure. In addition to higher marginal bone loss around implants, the cellular and molecular responses to injury and implant physicochemical properties are also differentially affected in smokers. The purpose of this work is to determine if smoking impairs bone microstructure and extracellular matrix composition within the dental alveolar socket after tooth extraction. Alveolar bone biopsies obtained from Smokers (> 10 cigarettes per day for at least 10 years) and Ctrl (never-smokers), 7–146 months after tooth extraction, were investigated using X-ray micro-computed tomography, backscattered electron scanning electron microscopy, and Raman spectroscopy. Both Smokers and Ctrl exhibited high inter- and intra-individual heterogeneity in bone microstructure, which varied between dense cortical and porous trabecular architecture. Regions of disorganised/woven bone were more prevalent during early healing. Remodelled lamellar bone was predominant at longer healing periods. Bone mineral density, bone surface-to-volume ratio, mineral crystallinity, the carbonate-to-phosphate ratio, the mineral-to-matrix ratio, the collagen crosslink ratio, and the amounts of amino acids phenylalanine and proline/hydroxyproline were also comparable between Smokers and Ctrl. Bone microstructure and composition within the healing dental alveolar socket are not significantly affected by moderate-to-heavy smoking.
Rare variants in FANCA induce premature ovarian insufficiency
Authors: Yang Xi , Zhang Xiaojin , Jiao Jiao , Zhang Feng , Pan Yuncheng , Wang Qiqi , Chen Qing , Cai Baozhu , Tang Shuyan , Zhou Zixue , Chen Siyuan , Yin Hao , Fu Wei , Luo Yang , Li Da , Li Guoqing , Shang Lingyue , Yang Jialing , Jin Li , Shi Qinghua , Wu Yanhua 
Published: September 2019

Abstract
Premature ovarian insufficiency (POI) is a major cause of reduced female fertility and affects approximately 1% women under 40 years of age. Recent advances emphasize the genetic heterogeneity of POI. Fanconi anemia (FA) genes, traditionally known for their essential roles in DNA repair and cytogenetic instability, have been demonstrated to be involved in meiosis and germ cell development. Here, we conducted whole-exome sequencing (WES) in 50 Han Chinese female patients with POI. Rare missense variants were identified in FANCA (Fanconi anemia complementation group A): c.1772G > A (p.R591Q) and c.3887A > G (p.E1296G). Both variants are heterozygous in the patients and very rare in the human population. In vitro functional studies further demonstrated that these two missense variants of FANCA exhibited reduced protein expression levels compared with the wild type, suggesting the partial loss of function. Moreover, mono-ubiquitination levels of FANCD2 upon mitomycin C stimulation were significantly reduced in cells overexpressing FANCA variants. Furthermore, a loss-of-function mutation of Fanca was generated in C57BL/6 mice for in vivo functional assay. Consistently, heterozygous mutated female mice (Fanca+/−) showed reduced fertility and declined numbers of follicles with aging when compared with the wild-type female mice. Collectively, our results suggest that heterozygous pathogenic variants in FANCA are implicated in non-syndromic POI in Han Chinese women, provide new insights into the molecular mechanisms of POI and highlight the contribution of FANCA variants in female subfertility.
End-stage liver failure: filling the treatment gap at the intensive care unit
Authors: Chamuleau Robert A. F. M. , Hoekstra Ruurdtje 
Published: September 2019

Abstract
End-stage liver failure is a condition of collapsing liver function with mortality rates up to 80. Liver transplantation is the only lifesaving therapy. There is an unmet need for therapy to extend the waiting time for liver transplantation or regeneration of the native liver. Here we review the state-of-the-art of non-cell based and cell-based artificial liver support systems, cell transplantation and plasma exchange, with the first therapy relying on detoxification, while the others aim to correct also other failing liver functions and/or modulate the immune response. Meta-analyses on the effect of non-cell based systems show contradictory outcomes for different types of albumin purification devices. For bioartificial livers proof of concept has been shown in animals with liver failure. However, large clinical trials with two different systems did not show a survival benefit. Two clinical trials with plasma exchange and one with transplantation of mesenchymal stem cells showed positive outcomes on survival. Detoxification therapies lack adequacy for most patients. Correction of additional liver functions, and also modulation of the immune system hold promise for future therapy of liver failure.
On the dynamics of stock price bubbles: comments on a model by Miao and Wang
Authors: Sorger Gerhard 
Published: September 2019

Abstract
We consider the model by Miao and Wang (Am Econ Rev 108:2590–2628, 2018), in which endogenous collateral constraints may generate stock price bubbles. Whereas Miao and Wang (2018) characterize the local dynamics around stationary equilibria only under the assumption of risk neutral households, we extend this characterization to the case of risk aversion.
Second variation of Selberg zeta functions and curvature asymptotics
Authors: Fedosova Ksenia , Rowlett Julie , Zhang Genkai 
Published: September 2019

AbstractWe give an explicit formula for the second variation of the logarithm of the Selberg zeta function,Z(s), on Teichmüller space. We then use this formula to determine the asymptotic behavior as$$\mathfrak {R}s \rightarrow \infty $$Rs→∞of the second variation. As a consequence, for$$m \in {\mathbb {N}}$$m∈N, we obtain the complete expansion inmof the curvature of the vector bundle$$H^0(X_t, {\mathcal {K}}_t)\rightarrow t\in {\mathcal {T}}$$H0(Xt,Kt)→t∈Tof holomorphic m-differentials over the Teichmüller space$${\mathcal {T}}$$T, formlarge. Moreover, we show that this curvature agrees with the Quillen curvature up to a term of exponential decay,$$O(m^2 \mathrm{e}^{-l_0 m}),$$O(m2e-l0m),where$$l_0$$l0is the length of the shortest closed hyperbolic geodesic.
Large-scale habitat model reveals a key role of large trees and protected areas in the metapopulation survival of the saproxylic specialist Cucujus cinnaberinus
Authors: Bełcik Michał , Goczał Jakub , Ciach Michał 
Published: September 2019

AbstractDeforestation for agricultural purposes and logging over centuries has resulted in a significant loss of forest cover and the deep structural and functional simplification of persistent European woodlands, which has led to a large-scale decline in biodiversity. Despite recent reforestation efforts in many regions of Europe, populations of numerous forest species remain unrecovered. Due to the loss of ecological continuity and the simplification of the ecosystem structure and functionality, the value of secondary forests in sustaining habitat specialists is being questioned. Here, we build a large-scale habitat suitability model to predict the current potential of forests to host populations of the flagship European saproxylic beetleCucujus cinnaberinus. Our maximum entropy model revealed that the distribution of suitable habitats strongly corresponds to the occurrence of large and well-preserved forest complexes that are characterized by an ecological continuity of the stands. Among the analysed environmental variables, the mean tree diameter and distance to protected areas were the most important suitable habitat contributors. The optimum habitats were identified almost exclusively within some parts of the Carpathians and the northeastern part of the country, particularly in the Białowieża Forest, which include the best preserved European forests. Although a large number of small habitat patches was revealed across the country, these patches were highly scattered and had low predicted suitability. This study demonstrates that most woodlands are unsuitable forC. cinnaberinus, which points to the limited value of secondary forests for habitat specialists. Our findings emphasize the importance of large and intact forests with undisrupted ecological continuity as key areas for the persistence of the rare saproxylic beetle, which provokes questions about the effectiveness of reforestation as a tool for the conservation of forest habitat specialists.
The Implicit Association Test in health professions education: A&nbsp;meta-narrative review
Authors: Sukhera Javeed , Wodzinski Michael , Rehman Maham , Gonzalez Cristina M. 
Published: September 2019

Introduction Implicit bias is a growing area of interest among educators. Educational strategies used to elicit awareness of implicit biases commonly include the Implicit Association Test (IAT). Although the topic of implicit bias is gaining increased attention, emerging critique of the IAT suggests the need to subject its use to greater theoretical and empirical scrutiny.
Methods The authors employed a meta-narrative synthesis to review existing research on the use of the IAT in health professions education. Four databases were searched using key terms yielding 1151 titles. After title, abstract and full-text screening, 38 articles were chosen for inclusion. Coding and analysis of articles sought a meaningful synthesis of educational approaches relating to the IAT, and the assumptions and theoretical positions that informed these approaches.
Results Distinct, yet complementary, meta-narratives were found in the literature. The dominant perspective utilizes the IAT as a metric of implicit bias to evaluate the success of an educational activity. A contrasting narrative describes the IAT as a tool to promote awareness while triggering discussion and reflection.
Discussion Whether used as a tool to measure bias, raise awareness or trigger reflection, the use of the IAT provokes tension between distinct meta-narratives, posing a challenge to educators. Curriculum designers should consider the premise behind the IAT before using it, and be prepared to address potential reactions from learners such as defensiveness or criticism. Overall, findings suggest that educational approaches regarding implicit bias require critical reflexivity regarding assumptions, values and theoretical positioning related to the IAT.
THE CHERN–SCHWARTZ–MACPHERSON CLASS OF AN EMBEDDABLE SCHEME
Authors: ALUFFI PAOLO 
Published: September 2019

The Chern–Schwartz–MacPherson class of a hypersurface in a nonsingular variety may be computed directly from the Segre class of the Jacobian subscheme of the hypersurface; this has been known for a number of years. We generalize this fact to arbitrary embeddable schemes: for every subscheme$X$of a nonsingular variety $V$, we define an associated subscheme$\mathscr{Y}$of a projective bundle$\mathscr{V}$over$V$and provide an explicit formula for the Chern–Schwartz–MacPherson class of$X$in terms of the Segre class of $\mathscr{Y}$in $\mathscr{V}$. If$X$is a local complete intersection, a version of the result yields a direct expression for the Milnor class of$X$.For$V=\mathbb{P}^{n}$, we also obtain expressions for the Chern–Schwartz–MacPherson class of $X$in terms of the ‘Segre zeta function’ of$\mathscr{Y}$.
A China Carved and Collected: Ningbo Whitewood Figurines in the Long Twentieth Century
Authors: Shi Yuanxie 
Published: September 2019

AbstractHow is the craft history of ordinary woodcarvers different from the political and economic history of elites and literati? This article tells a transnational history of Ningbo miniature whitewood figurines that were first collected by Western travelers as souvenirs from the 1870s to 1940s and then shipped to the West as export craft from the 1950s to 1980s. The examination of the makers, buyers, and collectors of these figurines reveals a dialectic process between carving and collecting. Focusing on both the making and circulation of these figurines, the article uncovers a new layer in modern Chinese history: with the political regime changing from the imperial state to socialist state, the carving and business practices of local artisans continued at its own rhythm. Less than three and a half inches tall, Ningbo whitewood figurines represent a miniature China carved and consumed on a global scale during the long twentieth century.
Surgical management of acquired anterior glottic web: a systematic review
Authors: Fussey J M , Borsetto D , Pelucchi S , Ciorba A 
Published: September 2019

AbstractBackgroundAcquired anterior glottic web poses a significant challenge to laryngologists given its propensity to recur following treatment, and there are a wide variety of described techniques.MethodsA systematic review of the medical literature was undertaken in order to identify all articles pertaining to the management of acquired anterior glottic web.ResultsThirteen studies meeting the inclusion criteria were identified and analysed. All were retrospective series, with varying surgical techniques and outcome measures. Only two studies reported on the use of topical mitomycin C.ConclusionMucosal graft techniques and keel placement appear to improve success rates, but both carry risks and disadvantages. Based on the available evidence, the use of topical agents such as mitomycin C cannot be recommended in the management of acquired anterior glottic web.
An Actualist Explanation of the Procreation Asymmetry
Authors: Cohen Daniel 
Published: September 2019

AbstractWhile morality prohibits us from creating miserable children, it does not require us to create happy children. I offer an actualist explanation of this apparent asymmetry. Assume that for every possible world W, there is a distinct set of permissibility facts determined by the welfare of those who exist in W. Moral actualism says that actual-world permissibility facts should determine one's choice between worlds. But if one doesn't know which world is actual, one must aim for subjective rightness and maximize expected actual-world permissibility. So, because one should expect actual people to be worse off than they could have been if one creates a miserable child, creating a miserable child is subjectively impermissible. And because one should expect actual people to be at least as well off as they could have been if one fails to create a happy child, failing to create a happy child is subjectively permissible.
Logical Expressivism and Carroll's Regress
Authors: Besson Corine 
Published: September 2019

AbstractIn this paper, I address a key argument in favour of logical expressivism, the view that knowing a logical principle such as Modus Ponens is not a cognitive state but a pro-attitude towards drawing certain types of conclusions from certain types of premises. The argument is that logical expressivism is the only view that can take us out of Lewis Carroll's Regress – which suggests that elementary deductive reasoning is impossible. I show that the argument does not hold scrutiny and that logical cognitivism can be vindicated. In the course of the discussion, I draw substantially on a comparison with a similar argument in meta-ethics, for moral expressivism.
On Linguistic Evidence for Expressivism
Authors: Ruiz Andrés Soria , Stojanovic Isidora 
Published: September 2019

AbstractThis paper argues that there is a class of terms, orusesof terms, that are best accounted for by an expressivist account. We put forward two sets of criteria to distinguish between expressive and factual (uses of) terms. The first set relies on the action-guiding nature of expressive language. The second set relies on the difference between one's evidence for making an expressive vs. factual statement. We then put those criteria to work to show, first, that the basic evaluative adjectives such as ‘good’ have expressive as well as factual uses and, second, that many adjectives whose primary meanings are factual, such as ‘powerful’, also have expressive uses.
The role of allogeneic stem-cell transplant in myelofibrosis in the era of JAK inhibitors: a case-based review
Authors: Tiribelli Mario , Palandri Francesca , Sant’Antonio Emanuela , Breccia Massimo , Bonifacio Massimiliano 
Published: September 2019

Abstract
Allogeneic hematopoietic stem-cell transplantation (HSCT) is, at present, the only potentially curative therapy for myelofibrosis (MF). Despite many improvements, outcomes of HSCT are still burdened by substantial morbidity and high transplant-related mortality. Allogeneic transplant is generally considered in intermediate-2 and high-risk patients aged <70 years, but the optimal selection of patients and timing of the procedure remains under debate, as does as the role of JAK inhibitors in candidates for HSCT. Starting from a real-life clinical case scenario, herein we examine some of the crucial issues of HSCT for MF in light of recent refinements on MF risk stratification, data on the use of ruxolitinib before and after transplant and findings on the impact of different conditioning regimens and donor selection.
Exosomes derived from cardiac progenitor cells attenuate CVB3-induced apoptosis via abrogating the proliferation of CVB3 and modulating the mTOR signaling pathways
Authors: Li Xin , Yang Zuocheng , Nie Wenyuan , Jiang Jie , Li Shentang , Li Zhuoying , Tian Lang , Ma Xing 
Published: September 2019

AbstractViral myocarditis is potentially fatal and lacking a specific treatment. Exosomes secreted by cardiac progenitor cells (CPCs) have emerged as a promising tool for cardioprotection and repair. In this study, we investigated whether CPCs-derived exosomes (CPCs-Ex) could utilize the mTOR signal pathway to reduce the apoptosis in viral myocarditis. In vitro, exosomes were, respectively, added to H9C2 cells after CVB3 infection to detect the anti-apoptosis effect of CPCs-Ex. Compared with the controls, the apoptosis rate was reduced, accompanied with the depressed expression of viral capsid protein 1 (VP1) and pro-apoptosis factors of Bim/caspase families. Meanwhile, the phosphorylation of Akt, mTOR, and p70S6K were promoted, but that of 4EBP1 was suppressed. In vivo, the results of apoptosis, expression of CVB3 and pro-apoptosis factors, and phosphorylation of Akt/mTOR factors of CVB3-infected cardiomyocytes were consistent with that of vitro. Following that, we use Rapamycin and MK-2206 to inhibit the Akt/mTOR signaling pathway, meanwhile, Rattus 4EBP1, p70S6K, Akt1 and Akt2 were transfected to H9C2 cells to establish the stably transfected cell lines. In the group with Rapamycin or MK-2206 pretreatment, CPCs-Ex also could decrease the apoptosis of H9C2 cells and expression of CVB3 mRNA, followed by decreased expression of apoptosis factors. In Akt2, p70S6K and 4EBP1 overexpression groups, CPCs-Ex promoted CVB3-induced apoptosis, VP1 expression and cleavage of caspase-3. Our results therefore identify CPCs-Ex exerts an anti-apoptosis effect in CVB3-infected cells by abrogating the proliferation of CVB3 and modulating the mTOR signaling pathways as well as the expression of Bcl-2 and caspase families. Viral myocarditis, mainly caused by CVB3 infection, is lacking a specific treatment. Our study identified an anti-apoptosis role of CPCs-Ex in CVB3-infected cells and rats, which shown that CPCs-Ex may be an effective tool to treat viral myocarditis. We believe that with more in-depth research on the functionality of CPCs-Ex, there will be a breakthrough in the treatment of viral myocarditis.