bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cephalic cutaneous allodynia in children and adolescents with migraine of short duration: A retrospective cohort study
Authors: Levinsky Yoel , Zeharia Avraham , Eidlitz-Markus Tal 
Published: May 2018

Background Allodynia is prevalent in adults with migraine and has been associated with long disease duration and severe course. Studies of the pediatric population are sparse. The aim of this study was to evaluate the rate of cephalic cutaneous allodynia in children and adolescents within the first 6 months of migraine onset and to identify associated clinical and migraine-related parameters. Methods The electronic database of a tertiary pediatric headache clinic from 2014 to 2017 was retrospectively searched for all children and adolescents diagnosed with migraine headache within 6 months or less of symptom onset. Cephalic cutaneous allodynia was identified by validated questionnaire. Demographics, symptoms, and headache-related parameters were compared between patients with and without allodynia. Results The cohort included 119 patients, 69 girls (58.0%) and 50 (42.0%) boys, of mean age 11.6 ± 3.6 years. Mean time since onset of migraine disease was 3.6 ± 1.8 months. Cephalic cutaneous allodynia was reported by 31.1% of patients. It was significantly associated with female gender ( p = 0.03), older age at admission ( p = 0.037), older age at onset ( p = 0.042) migraine with aura ( p = 0.002), and higher rate of awakening pain ( p = 0.017). Conclusions Cephalic cutaneous allodynia may occur in children and adolescents already in the first 6 months of migraine onset. Contrary to adult studies, we found no association of allodynia with migraine frequency or long disease duration. Allodynia was significantly associated with migraine with aura, female gender, and awakening pain. A genetic tendency may contribute to the appearance of allodynia in the pediatric age group.
Simulation Gaming Can Strengthen Experiential Education in Complex Infrastructure Systems
Authors: McBurnett Lauren R. , Hinrichs Margaret M. , Seager Thomas P. , Clark Susan Spierre 
Published: May 2018

Background Despite federal directives to strengthen the resilience of critical infrastructure systems, existing education programs have not kept pace with ambitious policy goals. As post-war infrastructure ages, it is increasingly necessary for graduates to master systems thinking to understand the complex and interdependent nature of infrastructure. Whereas in traditional physical science and engineering courses, learning would take place in laboratory exercises, the scale and criticality of infrastructure present obstacles to experimental and experiential learning activities. Aim This article describes the experience of an educational simulation game, called the LA Water Game, to teach management of ageing water infrastructure as a complex socio-technical system. Method A total of over 200 participants in 16 workshops completed an introductory lecture, experimental scenario development, experiential game play, and participated in reflective group discussion. Qualitative data was collected during game play and debriefing interviews and was used to assess participant learning outcomes. Results Participant feedback affirmed that simulation gaming can reinforce the experimental, experiential, and reflective phases of the Kolb Learning Cycle. Subjects displayed cognitive and affective engagement, intrinsic motivation, and often reported improved understanding of complex systems attributes, including interdependencies, feedback loops, nonlinearity, and stochasticity.
Activity Aprons for Inpatients Requiring Individual Nursing Assignment Care: A Prospective Randomized Controlled Pilot Study
Authors: Ruff Michael W. , Fine Anthony , Mandrekar Jay , Sweeney Cindy , Jones Lyell K. , Klaas James P. 
Published: May 2018

Background: Activity aprons are commercially available products used to occupy patients with dementia at home or in long-term care facilities. We hypothesized that inpatient use of activity aprons could potentially reduce or eliminate behaviors that result in self-harm, increased nursing supervision, and restraint use in an inpatient hospital setting. Methods: A single-center prospective randomized controlled pilot study was performed from July 2015 to November 2016 comparing activity apron plus standard care versus standard care alone. Consecutively enrolled patients were randomized by stratified randomization using age (cutoff: 80 years) and preexisting diagnosis of dementia or cognitive impairment. Primary outcomes were safety and feasibility of apron use. Secondary outcomes included duration of hospitalization postrandomization and individual nursing assignment (IA), time in restraints, nonphysical restraints use, falls, apron-related complications, dismissal destination, and 30-day hospital readmission. Results: Thirty patients were enrolled, with 13 randomized to apron and 17 randomized to the control group. There was no statistically significant reduction in mean length of hospital stay (15.8 vs 21.5 day; P = .40), duration of IA compared to non-apron control group (6.4 vs 9.1, respectively; P = .39), or antipsychotic medication use (61.5% vs 70.6% in control group; P = .60). No complications secondary to apron use were seen. Conclusions: Activity aprons are a safe addition to the standard of care when managing encephalopathic patients in the inpatient setting. These aprons may have a role as part of a comprehensive complement of interventions to address delirium and encephalopathy in hospitalized patients.
Does the Beighton Score Correlate With Specific Measures of Shoulder Joint Laxity?
Authors: Whitehead Noah A. , Mohammed Khalid D. , Fulcher Mark L. 
Published: May 2018

Background: Evaluation of shoulder joint laxity is an important component of the shoulder examination, especially in the setting of shoulder instability. Measures of generalized joint laxity, particularly the Beighton score, are often recorded and used to help make management decisions in these cases. However, no evidence is available to show that the Beighton score corresponds to specific measures of shoulder joint laxity. Purpose: To assess the correlation between the Beighton score and validated measures of shoulder joint laxity. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 160 participants (age range, 16-35 years) with no history of shoulder joint abnormality were examined. The Beighton score, glenohumeral external rotation (standing and lying), glenohumeral abduction, and the sulcus sign were recorded. The relationship between the Beighton score and each measure of shoulder joint laxity was assessed. Results: A high proportion of participants (34%) had a Beighton score of 4 or higher. Rates of positive shoulder laxity tests were lower (11%-19%). A positive Beighton score was a poor predictor of abnormal shoulder laxity, with low sensitivity (range, 0.40-0.48) and low positive predictive values (range, 0.13-0.31). Spearman correlation coefficients demonstrated poor correlation between the Beighton score and all measures of shoulder joint laxity when assessed as continuous variables (range, 0.29-0.45). Conclusion: The Beighton score has poor correlation with specific measures of shoulder joint laxity and should not be considered equivalent to these tests as a method of clinical assessment.
What's the point of the BJPsych Bulletin?
Authors: Poole Norman 
Published: May 2018

SummaryThe incoming editor Dr Norman Poole sets out a vision for his tenure at the helm of the BJPsych Bulletin. There will be redoubled focus on training and educational articles and an engagement with the cultural and social ramifications of this most vital of specialisms.Declaration of interestDr Poole is editor of the BJPsych Bulletin.
Patient-Reported Symptoms and Impact of Treatment With Osimertinib Versus Chemotherapy in Advanced Non–Small-Cell Lung Cancer: The AURA3 Trial
Authors: Lee Chee Khoon , Novello Silvia , Rydén Anna , Mann Helen , Mok Tony 
Published: May 2018

Purpose Capturing patient-reported outcome data is important for evaluating the overall clinical benefits of new cancer therapeutics. We assessed self-reported symptoms of advanced non–small-cell lung cancer in patients treated with osimertinib or chemotherapy in the AURA3 phase III trial. Patients and Methods Patients completed the European Organisation for Research and Treatment of Cancer 13-item Quality of Life Questionnaire-Lung Cancer Module (EORTC QLQ-LC13) questionnaire on disease-specific symptoms and the EORTC 30-item Core Quality of Life Questionnaire (EORTC QLC-C30) on general cancer symptoms, functioning, global health status/quality of life. We assessed differences between treatments in time to deterioration of individual symptoms and odds of improvement (a deterioration or improvement was defined as a change in score from baseline of ≥ 10). Hazard ratios (HRs) were calculated using a log-rank test stratified by ethnicity; odds ratios (ORs) were assessed using logistic regression adjusted for ethnicity. Results At baseline, the questionnaires were completed by 82% to 88% of patients, and 30% to 70% had individual key symptoms. Time to deterioration was longer with osimertinib than with chemotherapy for cough (HR, 0.74; 95% CI, 0.53 to 1.05), chest pain (HR, 0.52; 95% CI, 0.37 to 0.73), and dyspnea (HR, 0.42; 95% CI, 0.31 to 0.58). The proportion of symptomatic patients with improvement in global health status/quality of life was higher with osimertinib (80 [37%] of 215) than with chemotherapy (23 [22%] of 105; OR, 2.11; 95% CI, 1.24 to 3.67; P = .007). Proportions were also higher for appetite loss (OR, 2.50; 95% CI, 1.31 to 4.84) and fatigue (OR, 1.96; 95% CI, 1.20 to 3.22). Conclusion Time to deterioration of key symptoms was longer with osimertinib than with chemotherapy, and a higher proportion of patients had improvement in global health status/quality of life, demonstrating improved patient outcomes with osimertinib.
Online Piracy and the “Longer Arm” of Enforcement
Authors: Dey Debabrata , Kim Antino , Lahiri Atanu 
Published: May 2018

Controlling digital piracy has remained a top priority for manufacturers of information goods, as well as for many governments around the world. Among the many forms taken by digital piracy, we focus on an increasingly common one—namely, online piracy—that is facilitated by torrent sites and cyberlockers who bring together consumers of pirated content and its suppliers. Motivated by recent empirical literature that makes a clear distinction between antipiracy efforts that restrict supply of pirated goods (supply-side enforcement) and ones that penalize illegal consumption (demand-side enforcement), we develop a simple economic model and discover some fundamental differences between these two types in terms of their impacts on innovation and welfare. All in all, supply-side enforcement turns out to be the “longer arm”—it has a more desirable economic impact in the long run. Our results have clear implications for manufacturers, consumers, and policy makers. The online supplement is available at https://doi.org/10.1287/mnsc.2017.2984 . This paper was accepted by Chris Forman, information systems.
Reduced order methods for nonlinear parametric problems with branching solutions
Authors: Pichi Federico , Hess Martin Wilfried , Quaini Annalisa , Rozza Gianluigi 
Published: May 2018

The aim of this work is to show the applicability of the reduced basis model reduction in nonlinear systems undergoing bifurcations. Bifurcation analysis, i.e., following the different bifurcating branches, as well as determining the bifurcation point itself, is a complex computational task. Reduced Order Models (ROM) can potentially reduce the computational burden by several orders of magnitude, in particular in conjunction with sampling techniques. In the first task we focus on nonlinear structural mechanics, and we deal with an application of ROM to Von Kármán plate equations, where the buckling effect arises, adopting reduced basis method. Moreover, in the search of the bifurcation points, it is crucial to supplement the full problem with a reduced generalized parametric eigenvalue problem, properly paired with state equations and also a reduced order error analysis. These studies are carried out in view of vibroacoustic applications (in collaboration with A.T. Patera at MIT).
As second task we consider the incompressible Navier-Stokes equations, discretized with the spectral element method, in a channel and a cavity. Both system undergo bifurcations with increasing Reynolds - and Grashof - number, respectively.
Applications of this model are contraction-expansion channels, found in many biological systems, such as the human heart, for instance, or crystal growth in cavities, used in semiconductor production processes. This last task is in collaboration with A. Alla and M. Gunzburger (Florida State University).
A Model of Flexible Learning: Exploring Interdependent Relationships Between Students, Lecturers, Resources and Contexts in Virtual Spaces
Authors: Bostock John Raymond 
Published: May 2018

In flexible and open models of education students and lecturers experience a virtual sense of separation that is caused by more than physical distance between students and lecturers. Transactional distance is “a psychological and communications gap, a space of potential misunderstanding between the inputs of lecturer and those of the student” created in part by the physical distance inherent to online learning (Moore 1991, p. 2). a large transactional distance such as that between geographically dispersed students and lecturers in an asynchronous, text-based, online learning environment may contribute to students’ feelings of isolation and disconnectedness, which can lead to reduced levels of motivation and engagement and consequently attrition.
When designing e-learning experiences lecturers must consider two variables that affect transactional distance: structure and dialogue. Structure refers to the flexibility or rigidity of the pedagogical methods and strategies used in an e-learning experience. Dialogue refers to the interaction between the lecturer and student during an e-learning experience. Moore does not suggest that either structure or dialogue are inherently good things. Each may be appropriate in different circumstances and a typical educational event such as a conventional lecture will, at a micro-level, move constantly between the two. Another dimension of the theory suggests that more autonomous students, being self-directed, are better able to cope with more structure while less autonomous students benefit more from greater dialogue.
This paper explores a proposed model of flexible learning which attempts to inform practitioners of the fluid, interdependent relationships between students, resources, contexts and lecturers. This helps explain and justify a reconceptualisation of the role of the lecturer and suggests how social activity is also pivotal in successful learning outcomes for students.
Bacteriemia por Campylobacter fetus: a propósito de dos casos.
Authors: Bernasconi Carla Beatriz 
Published: May 2018

Las bacterias del género Campylobacter son bacilos gram-negativos, helicoidales y finos. Son de crecimiento lento. Las especies comúnmente encontradas como patógenos humanos son: Campylobacter jejuni y Campylobacter fetus subespecie fetus. C. jejuni, se asocia a brotes de enfermedades transmitidas por agua y/o alimentos en pacientes en general sanos. En cambio, C. fetus se caracteriza por manifestaciones sistémicas, en especial en huéspedes inmunocomprometidos. Se presentan dos casos de bacteriemia por Campylobacter fetus en pacientes con diagnóstico previo de enfermedad renal, en tratamiento prolongado con prednisona. Ambos pacientes concurren a establecimientos de salud por malestar general. Se toman muestras de hemocultivos, en las cuales desarrollan a las 72 horas colonias puntiformes grises, que a la coloración de Gram resultan bacilos negativos finos en forma de coma y alas de gaviota. Ambos aislamientos se derivaron para su identificación por el método de espectrometría de masas (MALDI-TOF); y fueron caracterizados como Campylobacter fetus. Luego del tratamiento instaurado, la evolución fue favorable en ambos pacientes.Finalmente, deberíamos considerar a C. fetus como un patógeno a tener en cuenta en los síndromes febriles de pacientes inmunocomprometidos, aunque éstos no presenten manifestaciones digestivas.
Bacteriemia por Campylobacter coli en Tierra del Fuego
Authors: LONGONI SILVIA 
Published: May 2018

Resumen El género Campylobacter, comprende un grupo de bacterias formado por bacilos gram negativos, microaerófilos, de morfología espirilar, hallados en el tubo digestivo de animales, en particular aves. Pueden producir eventualmente infecciones extraintestinales. El objetivo de este trabajo es comunicar un caso de bacteriemia por Campylobacter coli en una paciente inmnosuprimida, de 57 años con linfoma no Hodgkin, quien presentaba infección de sitio quirúrgico por una biopsia de ganglio inguinal. Se tomaron muestras por punción de la zona infectada para cultivo y dos hemocultivos, obteniéndose resultados positivos a las 48h de incubación de las muestras de sangre, pero sin desarrollo en el material de punción de la herida. En la coloración de Gram se observaron bacilos gram negativos espiralados. Los microorganismos fueron identificados como Campylobacter coli por tecnología MALDI-TOF BD®, directamente desde el medio de cultivo líquido, también por cultivo en medio sólido e identificación bioquímica. El hallazgo desconcertó a los profesionales tratantes, ya que no era lo esperado. El aislamiento de Campylobacter coli pudo vincularse con un episodio de diarrea que la paciente no refirió anteriormente. Se pudo demostrar que dicho microorganismo desarrolla sin inconvenientes en las botellas de hemocultivos automatizados.Palabras clave: Campylobacter coli, hemocultivos, espiralados, MALDI-TOF BD®
CONSUMO DE LA SEMILLA DE CHIA (SALVIA HISPANICA L): POSIBLES MECANISMOS DE ACCION SOBRE EL MEJORAMIENTO DE LA DISLIPIDEMIA, RESISTENCIA INSULINICA Y ADIPOSIDAD VISCERAL EN MODELOS EXPERIMENTALES Y SU EXTENSION AL HUMANO. ESTUDIO DE REVISION.
Authors: Chicco Adriana 
Published: May 2018

Diferentes estudios sugieren que los ácidos grasos poliinsaturados de cadena larga de la familia n-3 (n-3 LCPUFAs) cumplen un rol importante en el mantenimiento de la salud. Diferentes semillas y aceites vegetales son ricos en el ácido graso esencial a-linolénico (ALA, 18:3 n-3) precursor natural de los ácidos grasos n-3 de cadena más larga como el ácido eicosapentaenoico (EPA, 20:5 n-3) y docosahexaenoico (DHA, 22:6 n-3), entre otros. El ALA ha cobrado gran importancia dado que numerosos trabajos epidemiológicos en humanos y en animales de experimentación sugieren que un elevado consumo de ALA ejerce efectos beneficiosos en la prevención de la enfermedad cardiovascular, mejorando la dislipidemia, la sensibilidad insulínica y la tolerancia a la glucosa,modificando la respuesta a la acción insulínica en los tejidos claves. La Salvia hispánica L (chía) es uno de las fuentes vegetales más importante de ALA que contiene además un buen aporte de fibra dietaria, proteína con alta actividad biológica y abundantes compuestos con capacidad antioxidante. En esta revisión examinaremos los hallazgos más importantes y recientes del efecto de la semilla de chía dietaria sobre la prevención y/o mejoramiento de la dislipidemia, lipotoxicidad, insulino resistencia, alterada homeostasis de la glucosa y adiposidad visceral en modelos experimentales, con extensión a estudios recientes en humanos. Particularmente analizaremos los mecanismos metabólicos y moleculares involucrados en dichas acciones.
Stabilitas warna basis gigitiruan resin termoplastik nilon yang direndam dalam larutan pembersih gigitiruan peroksida alkalin Color stability of thermoplastic nylon denture base material immerse in alkaline peroxide denture cleanser
Authors: Awing Melinda Maria , Koyama Angela Thomas 
Published: May 2018

This study aimed to determine the effect of alkaline peroxide denture cleanser on the color stability of thermoplasticnylon denture base. This experimental laboratory research with pretest posttest with control group design used 24specimens of thermoplastic nylon (valplast) sized 20x20x2 mm as samples. Twelve specimens immersed in alkalineperoxide denture cleanser solution and the other twelve specimens immersed in aquadest as control. Time intervalsubmergence once for 1 hour, 8 hours and 12 hours each consisting of 4 specimens in alkaline peroxide solution and 4specimens in control solution. They were immersed in 8-hours time interval submergence times 7 by changing thesolution of alkaline peroxide every 8 hours, using 4 speciments for each solutions. Using ANOVA and independent ttest,it showed no significant color changes on thermoplastic nylon resin after immersed in alkaline peroxide solution based on the time interval. However, there was significant color difference on the thermoplastic nylon resin immersed in alkaline peroxide and control solution at second to seventh interval of 8 hours immersed time with increase of time immersing. It was concluded that thermoplastic nylon resin have good stability although immerse in alkaline peroxide denture cleanser
Effect of use of nail polish on bacterial colonization after surgical handwashing in operating room nurses: a preliminary study
Authors: YILDIRIM TANK Dilek , ÇELİK Sevim 
Published: May 2018

Purpose: This study aims to analyze the effect of nail polish applied by operating room nurses on bacterial colonization after surgical hand washing. Materials and Methods: This is a self-controlled, experimental study in which the before and after values of the same group were analyzed. This study was conducted on 33 operating room nurses. The glove juice method was used to measure bacterial colonization on the nurses' hand flora. The data were collected using the Introductory Information Form for Nurses and the Data Recording Form. The data were analyzed using descriptive statistical methods along with the Wilcoxon test. Results: Of the nurses, 54.56% had a bachelor's degree, 78.8% had been working as a nurse for at least 11 years, and 63.7% had been working as an operating room nurse for at least 11 years. Of them, 66.7% had nails shorter than 2 mm. and 60.6% sometimes used moisturizer. No statistically significant difference was found between the amount of bacteria in the samples obtained from the nurses' hands with and without nail polish after surgical hand washing.Conclusion: The findings showed that freshly applied nail polish has no effect on bacterial colonization.
A Woman of Many Parts
Authors: Morgan Peggy 
Published: May 2018

This article seeks to demonstrate the wide-ranging nature of Professor Ursula King’s research and intellectual interests within the field of religious studies. It highlights her personal engagement not only with issues in science, ecology and religions, Hinduism, education, spirituality, feminist and gender studies on an international stage, but also her involvement dialogically with the people whose work and religious lifeways she has encountered. It shows a continuing and remarkable vitality and freshness in an arena of interests across both local, personal and global issues.