bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitro Efficacy of Tulsi (Ocimum sanctum) based Extract against Soil Borne Fungi
Authors: Kaur Parneet , Sharma Indu , Kumar Rahul , Sharma Sonika , Shiwani Kumari , Sharma Aditi , Sharma Ashutosh 
Published: November 2024

In the present study, antifungal effect of different concentrations of aqueous Tulsi (Ocimum sanctum) extract and Tulsi-AgNO3 mix was tested in vitro against Alternaria, Fusarium and Rhizoctonia. The study was conducted from February to November in the year 2020. Overall results suggested that Tulsi extract significantly inhibited (above 70%) the mycelial growth of soil borne fungi. Highest concentration of Tulsi extract resulted in 77.43% growth inhibition against Alternaria solani and 76.75% inhibition of Rhizoctonia solani. Tulsi-AgNO3 showed less inhibition of pathogenic fungi compared to the treatments where only Tulsi extract was used. Results show a dose-dependent inhibition of radial growth across all fungi, with Alternaria spp. displaying the highest sensitivity, achieving over 58% inhibition at 1000 ppm. In contrast, Rhizoctonia solani exhibited the lowest sensitivity, with inhibition percentages peaking at 29.64% at 1000 ppm. These findings suggest that the Tulsi extract is a promising antifungal agent, although its efficacy varies by fungal species, indicating the potential need for targeted or combination treatments for effective pathogen control.
The synthesis, antimicrobial activity and theoretical calculations of 4-(4,5-diphenyl-1-(4-(phenyldiazenyl)phenyl)-1H-imidazol-2-yl)-N,N-dimethylaniline
Authors: Abbasov Vagif , Orujova Nargiz , Mammadov Ayaz , Jafarova Rana , Ahmadbayova Saida , Muradova Sevda , Akhmedov Elshan 
Published: November 2024

Aim. To synthesize 4-(4,5-diphenyl-1-(4-(phenyldiazenyl)phenyl)-1H-imidazol-2-yl)-N,N-dimethylaniline, as well as make theoretical calculations of its structure and study its antimicrobial properties.
Materials and methods. The synthesis procedures were performed in the presence of ionic liquid catalysts and under microwave conditions. The catalysts included 1-butyl-3-methylimidazolehydrosulfate, N-methylpyrrolidone perchlorate, and 1,4-dimethylpiperazinedihydrosulfate ionic liquids. Benzyl, ammonium acetate, p-aminoazobenzene and 4-(dimethylamino)benzaldehyde were taken as reagents. Ethanol was used as a solvent.
Results. The results of the conditions were compared and it was determined that the 1,4-dimethylpiperazinedihydrosulfate catalyst reacted under microwave conditions in a shorter time (19 min) with a higher yield (78.1 %). The structure of the compound synthesized was analyzed by 1H, 13C NMR and IR spectroscopy. The theoretical calculations of the compound were determined using the density functional theory (DFT/B3LYP) method with a basic set of 6-31G(d,p). The geometry of the structure was optimized, bond lengths, angle degrees were given, and important quantum chemical parameters, such as HOMO, LUMO orbitals, reactivity, stability, electrophilicity, electronegativity, chemical softness, chemical hardness were calculated. It was found that the compound had a high stability (∆E = 2.359 eV) and a high biological activity (ω = 5.754 eV). The antimicrobial activity of the sample against bacteria of S. aureus, E. coli, P. aeruginosa, K. pneumoniae, B. anthracoides and C. albicans fungus was studied.
Conclusions. In this work, 4-(4,5-diphenyl-1-(4-(phenyldiazenyl)phenyl)-1H-imidazol-2-yl)-N,N-dimethylaniline has been synthesized from benzyl, ammonium acetate, p-aminoazobenzene and 4-(dimethylamino)benzaldehyde in the presence of microwave and ionic liquid catalysts. It has been determined that 1,4-dimethylpiperazinedihydrosulfate catalyst reacts under microwave conditions in a shorter time (19 min) with a higher yield (78.1 %). The compound has been tested as an antimicrobial agent against bacteria of S. aureus, E. coli, P. aeruginosa, K. pneumoniae, B. anthracoides and C. albicans fungus, showing moderate and higher activity.
The study of the toxicological profile of dry extracts of narrow-leaved lavender herb
Authors: Bogatyrova O. O. , Naboka O. I. 
Published: November 2024

Aim. To study the acute toxicity of narrow-leaved lavender (Lavandula angustifolia) herb dry extracts of Ukrainian origin.
Materials and methods. The study objects were experimental test samples: test sample No. 1 ‒ a dry extract of narrow-leaved lavender herb obtained by extraction with purified water; test sample No. 2 ‒ a dry extract of narrow-leaved lavender herb obtained by extraction with a water‒ethanol solution (40 % ethanol); test sample No. 3 ‒ a dry extract of narrow-leaved lavender herb obtained by extraction with a water‒ethanol solution (70 % ethanol). To reproduce the clinic of acute poisoning and determine LD50, the acute toxicity of test samples was studied on sexually mature white mice weighing 19-21 g under the conditions of a single intragastric administration. The animals were observed for 2 weeks, which made it possible to assess the toxic effect of the lavender extracts studied on the body of experimental animals. The weight (initial data, 3, 7 and 14 days), the behavior of animals after the introduction of test samples (appearance, respiration, salivation, urination, excreta, feed consumption by animals) were monitored by daily feed and water consumption ‒ on days 7 and 14. The macroscopic examination included the external examination of animals, the examination of internal organs of the chest (heart, lungs, thymus) and abdominal cavities (liver, spleen, kidneys, adrenal glands, testes/ovaries). For statistical processing of the data obtained (body weight), the arithmetic average value and its standard error were used; the reliability of discrepancies between samples was assessed using ANOVA RM and the Dunnet criterion. Comparisons were made with the negative control group. Indicators of the mass coefficients of internal organs were presented in the form of the median, upper and lower quartiles. The reliability of discrepancies between samples was assessed using the Kruskal-Wallis test and the Mann-Whitney test compared to the negative control group.
Results and discussion. It was experimentally proven that intragastric administration of dry extracts from lavender herb in the dose of 5000 mg/kg did not lead to lethality and did not affect the general trophic processes of animals. The macroscopic examination of internal organs and analysis of their mass coefficients confirmed that a single intragastric administration of test samples of lavender extracts did not lead to pathological changes in both males and females. The organ mass coefficients were within the normal range and had no statistically significant differences compared to animals in the negative control group.
Conclusions. The results of the study have demonstrated that a single intragastric administration of test samples of lavender in the dose of 5000 mg/kg does not lead to pathological changes in the physiological state of mice, which allows to attribute the extracts studied to class V of practically non-toxic substances (LD50 > 5000 mg/kg).
Organizational and economic studies of the turnover of anthelmintic drugs in the domestic pharmaceutical market in modern conditions
Authors: Bratishko Yu. S. , Semchenko K. V. , Tolochko V. M. , Zarichkova M. V. , Zoidze D. R. , Dolzhnikova O. M. 
Published: November 2024

Aim. To conduct organizational and economic studies of the peculiarities of the turnover of anthelmintic drugs in the domestic pharmaceutical market in modern conditions under the influence of high risks and uncertainties.
Materials and methods are based on open access information for professional use by doctors and pharmacists, materials from scientific publications and monographic editions of domestic and foreign scientists, the results of personal research using Google forms. For the survey, 90 pharmacy specialists were involved as respondents. The results were processed and verified using licensed Microsoft Excel software products.
Results and discussion. The list of anthelmintic drugs, which are in circulation in the domestic pharmaceutical market in modern conditions, has been determined. The organizational and economic features of each of them, such as the level of demand and cost indicators, have been outlined. It has been found that there are 24 names of such anthelmintic drugs, including 11 based on the active substance albendazole, 7 based on pyrantel, 2 based on mebendazole, 3 based on levomizole and one herbal tea based on tansy flowers. The most popular anthelmintic drugs in modern conditions, the level of demand for which exceeds 70.0 % (7 items), have been determined. Certain features of the actions of pharmacy specialists when dispensing anthelmintic drugs from pharmacies, which can contribute to the formation of demand for them, have been studied, including 18 questions according to the respondents’ rating.
Conclusions. The results of the study conducted have allowed determining the peculiarities of the turnover of anthelmintic drugs in the domestic pharmaceutical market in modern conditions under the influence of high risks and uncertainties. Their list, level of demand and cost indicators have been defined, as well as certain recommended actions of the pharmacy specialists when dispensing from pharmacies.
Receptor interacting serine/threonine kinase 2 promotes rheumatoid arthritis progression and partially regulates nuclear factor kappa B pathway
Authors: Wang Yanzheng , Xu Meiyu , Liu Xinxin , Liu Deheng 
Published: November 2024

Objective:
Rheumatoid arthritis (RA) is a disabling systemic autoimmune disease worldwide; however, its molecular pathway remains largely unknown. Thus, this study aimed to explore the effects of receptor-interacting serine/threonine kinase 2 (RIPK2) on RA progression and its underlying mechanism.

Material and Methods:
RIPK2 expression was analyzed using real-time quantitative polymerase chain reaction, immunohistochemical staining, and Western blot (WB) analysis in RA synovial tissues or cells. Cell viability or proliferation was determined using the cell counting kit-8 and 5-ethynyl-2'-deoxyuridine. Cell metastasis was analyzed using the transwell assay and wound healing assay. Flow cytometry was adopted to measure cell apoptosis. The level of inflammation-related factors was measured using the enzyme-linked immunosorbent assay. WB analysis was used to determine the expression level of nuclear factor kappa B (NF-κB) pathway-related genes.

Results:
RIPK2 was highly expressed in RA synovial tissues and cells. Transfection with RIPK2 short hairpin RNA plasmids reduced the gene expression level of RIPK2 in RA fibroblast-like synoviocytes (FLS) cells. Notably, RIPK2 silencing hindered the proliferation, invasion, and migration of tumor cells as well as accelerated the apoptosis of RA-FLS cells. Furthermore, RIPK2 silencing suppressed the RA-FLS cell inflammatory response and NF-κB pathway.

Conclusion:
RIPK2 silencing could retrain the malignant behavior and inflammatory response of RA-FLSs and partially modulate the NF-κB pathway.
المراكز الناشئة بالأطلس المتوسط الشمالي الشرقي بين رهان تنظيم المجال وبلوغ التنمية المستدامة: حالة مركز الزراردة - إقليم تازة- المغرب
Authors: محمد كميحي , البزوي جواد , بوبرية عبدالواحد 
Published: November 2024

أفرزت التحولات المجالية والترابية التي شهدها التراب المغربي، ظهور كيانات مجالية جديدة اصطلح عليها بالمركز الناشئة والصاعدة، حيث شكلت أداة استراتيجية في إعادة هيكلة المجال المغربي ووسيلة لخلق التوازن الترابي عبر نشر التمدين بمجالات جديدة، كما مكنت من تحقيق استقرار للساكنة داخلها بشكل ساهم في تقليص الضغط على المجالات الحضرية الكلاسيكية. شهدت جبال الأطلس المتوسط الشمالي الشرقي تحولات ترابية مهمة، إذ ظهرت بها مجموعة من المراكز الناشئة، انتقلت من تجمعات قروية بسيط إلى مراكز قائمة الذات تتوفر على عدد مهم من المرافق والتجهيزات المهمة، والتي ساعدتها في تنظيم مجالها الريفي، ومن تحقيق استقطاب ترابي لمختلف المكونات الترابية المحيطة بها. وفي هذه الورقة العلمية سنحاول تسليط الضوء على واقع حال مركز الزراردة، ككيان ناشئ بالأطلس المتوسط الشمالي الشرقي، مع وضع تصور للمداخيل الأساسية التي تمكن من الوصول إلى تنمية مستدامة داخل هذا الحيز الترابي.
MODELO DE GESTIÓN DE CALIDAD DE LA EMPRESA PÚBLICA DE AGUAS POTABLE Y ALCANTARILLADO DE RIOBAMBA, ECUADOR
Authors: Hernández José Armando Estrada , Espinoza Magdala de Jesús Lema , Teheran Harold Elbery Escobar , Quintero Frank Ángel Lemoine 
Published: November 2024

Objetivo: Aplicación de un modelo de gestión de calidad de vida laboral, que propicia un elevado desempeño empresarial y la efectividad en la prestación de los servicios de la empresa pública de aguas potable y alcantarillado (Ep-Emapar) del cantón Riobamba, provincia de Chimborazo, de Ecuador.

Marco Teórico: En este tema se presentan los principales conceptos y teorías que sustentan la investigación. Granados I. (2011) el “término calidad de vida laboral tuvo sus orígenes en una serie de conferencias patrocinas al final de los años 60 y comienzos de los 70 por el Ministerio de Trabajo de los EE.UU. y la Fundación FORD.

Método: Las tendencias metodológicas para evaluar la calidad de vida combinan enfoques cuantitativos y cualitativos, cada uno contribuyendo al desarrollo de instrumentos, indicadores y escalas que buscan abarcar la mayor cantidad de dimensiones posibles, dada la naturaleza multidimensional de este concepto. Entre los materiales y métodos y de modo general nos enfocaremos en aspectos que ofrecen, luego de su aplicación, los resultados obtenidos.

Resultados y Discusión: El análisis de los resultados muestra fortalezas en bienestar físico y emocional, y desarrollo personal; sin embargo, existe una necesidad de mejorar en inclusión social, relaciones interpersonales y autodeterminación, lo que limitaría la cohesión y motivación del equipo.

Implicaciones de la Investigación: Esta investigación permite identificar áreas clave de mejora en la calidad de vida laboral, como inclusión social, relaciones interpersonales y autodeterminación.

Originalidad/Valor: Este estudio aporta un modelo de gestión innovador para mejorar la calidad de vida laboral en EP-EMAPAR, optimizando el desempeño y bienestar del personal, y generando un impacto positivo en el servicio público y la comunidad.
Research on the Communication and Development of Heilongjiang Cultural and Creative Industry under the Background of “Belt and Road”
Authors: Guan Yingnan , Zhang Dongyang 
Published: November 2024

This paper focuses on the research on the dissemination and development of cultural and creative industries in Heilongjiang Province under the background of “Belt and Road.” Firstly, the paper analyzes the main characteristics of cultural and creative industries in Heilongjiang Province and then puts forward the leading advantages of the government to promote the development of cultural and creative industries. The government gives full play to its regional advantages and creates Longjiang cultural products, while also accelerating regional industrial cooperation and innovative cultural communication forms. In-depth discussion is made on integrating scientific and technological means of the times and strengthening the cultivation of innovative talents. The government optimizes the communication and development path of the Heilongjiang cultural entrepreneurship industry and brings positive influence to the stable development of the Heilongjiang region in the future.
segador
Authors: Litvak Lily 
Published: November 2024

España heredó la cultura agrícola latina y con ella el cultivo del cereal. La obras de Catón el Viejo; De Agricultura (160 AC), de Varron De Res Rustica (37 AC), Las Geórgicas de Virgilio (29 AC) y más precisamente la Geórgica I explican el concepto del “labor” del campesino en las labranzas y citan las herramientas utilizadas en la agricultura. Estas también son descritas por el hispano-romano Columela, nacido en Cádiz en el año 4 de nuestra era. Fue autor de dos importantes libros: De Re rustica y De arboribus, y menciona varias guadañas para cosechar y las palas planas para cargar o aventar el grano. En el siglo IV Paladio en su Tratado de Agricultura, resume a los autores latinos y sobre todo a Columela y entre las herramientas incluye el arado simple, el arado de orejas, la azada de dos puntas, el hacha pico, la hachuela, el podón y diversos tipos de guadañas. Es lógico que entre los primeros cultivos presentes en Cataluña se encuentre el cereal, establecido entre los siglos IX al XI sobre todo en las partes prepirienéica y central por las tempranas repoblaciones de hispani. Los colonos convirtieron ciertas partes cubiertas de bosque y matorral en tierras de cultivo, logrando parcelas fijas o itinerantes que aprovechaban la fertilidad de los suelos forestales. En esas tierras se cultivaron diferentes variedades de trigo, centeno, mijo y algo de cebada. Ese fue el origen y el desarrollo de una población rural que formó parte de la historia de la región. La pintura del paisaje con temas agrarios fue muy valorada desde mediados del siglo XIX por la influencia del realismo. El romanticismo no había apreciado un paisaje que aparecía con campos acotados y utilizados por el hombre. Era contrario a la idea romántica de la naturaleza que exaltaba el misterio de la montaña, los bosques, las cataratas, las formas enigmáticas de las nubes y las rocas… Aunque los temas del cultivo del campo aparecieron en la pintura desde la antigüedad, éstos eran solo una manera de marcar determinadas fechas o para contextualizar alguna lección moral.
Self-efficacy and academic performance in higher education: a case study
Authors: Figueiredo Elisa , Fonseca Cecília , Paiva Teresa 
Published: November 2024

Introduction: There is a large body of research showing that self-efficacy is a crucial predictor of student achievement. Based on this framework, this study aims to investigate the correlation between students' general self-efficacy (GSE) and Social self-efficacy (SSE) and academic performance, as well as the relationship between GSE and SSE with age and gender.
Methodology: Our approach was quantitative, descriptive, and cross-sectional. The target population was all students enrolled during the academic year 21/22 at a Portuguese higher education institution. Results: The results indicate that students with a high level of GSE perform better than those with lower GSE and the level of GSE depends on age and gender. Although, no correlation was identified for SSE and student performance. Discussion: From the results it was possible to corroborate the following study hypothesis: students with a high level of GSE perform better than those with lower GSE, the level of GSE and SSE depends on age and gender. Although the hypothesis set students with a high level of SSE perform better than those with lower SSE was not supported. Conclusions: This investigation could support strategies to promote self-efficacy in students with the aim of improving their academic performance.
Soledad Bengoechea Gutiérrez (1849-1893): un análisis hemerográfico de su trayectoria musical
Authors: Navarro Lalanda Sara 
Published: November 2024

Introducción: El presente estudio examina el papel de la pianista y compositora Soledad Bengoechea Gutiérrez en los círculos musicales madrileños a través del análisis de fuentes hemerográficas contemporáneas. Metodología: Se emplea una metodología cualitativa respaldada por el software Nvivo basada en la Teoría Fundamentada. La investigación se sustenta en una revisión crítica de registros hemerográficos que abarcan desde el nacimiento de Bengoechea en 1849 hasta el año 1915, profundizando en su rol como solista y acompañante y en su legado como compositora en términos de instrumentación, difusión y recepción. Resultados: Los resultados muestran que Bengoechea desempeñó un papel significativo en la escena musical de su tiempo. Discusión: Su participación y reconocimiento como pianista y compositora fueron avalados tanto por las crónicas de los periódicos como por las instituciones que difundieron su obra. Conclusiones: Este estudio contribuye significativamente a llenar un vacío en la investigación musicológica, destacando el papel de Bengoechea como pianista y compositora en el siglo XIX. Al mismo tiempo, este análisis crítico no solo profundiza nuestra comprensión de Bengoechea, sino que también amplía el conocimiento sobre los círculos de difusión de la música en el siglo XIX español.
Colorectal Cancer and Gut Microbiota
Authors: Shukur Shubin Abdul , Jadhav Ashish Anantrao , Kotnis Ashwin 
Published: November 2024

Colorectal cancer is the third most diagnosed cancer globally, accounts for 9.6% 0f all cancer diagnosed and 9.3% of all cancer deaths. Most cases of colorectal cancer, about 80% are sporadic in origin, and the remaining 20 % are hereditary. Colorectal cancer have the risk factors like family history, diet, comorbities, smoking, alcohol, medication research also shows that there is alteration in the gut microbiota of colorectal cancer. Gold standard investigation for diagnosis of colorectal cancer is colonoscopy with biopsy for histopathology. Human gut microbiota is the colony of comprises more than 1014 microbes like bacteria, virus and fungi. The normal commensal microorganism present in the gut microbiota have symbiotic association with the intestine helps in digestion and absorbtion. Colorectal cancer as it involve chronic inflammatory response leads to decrease in the biodiversity of microorganism and presence of pathological microorganism and this is used as a biomarker for the colorectal cancer. Fecal sample metagenomic analysis shown increase in Fusobacterium nucleatum, Parvimonas, Peptostreptococcus, Porphyromonas, and Prevotella, are part of the CRC microbiota. This is a promising noninvasive biomarker for colorectal cancer.
Keywords: Colorectal cancer, Gut microbiota, Fusobacterium nucleatum, Bacteroides fragilis
Analisis Hukum Acara Peradilan Agama terhadap Putusan Pengadilan Agama dengan No Register 1/PDT.G.S/2023/PA.LMG
Authors: Abd Hafid  , Faizatul Arif Alfiyah 
Published: November 2024

Starting from a lawsuit filed by the Debtor against the banking and financing institution PT. Pemodalan Nasional Madani (PNM) Lamongan branch to the Lamongan Religious Court regarding alleged violations of unlawful acts, namely the auction of a plot of house used as collateral at PT. PNM. The reason for filing a lawsuit with the Lamongan Religious Court is because the agreement agreed upon by the parties is a Mudharabah contract. In the trial process at the Lamongan Religious Court with registration No. 1/G.S/2023/PA.Lmg. by issuing a verdict before the parties, the Plaintiff and the defendant were given the opportunity to make answers, namely the reading of the lawsuit, the submission of duplicate replica answers from the defendant. However, after the submission of the mediation results failed, then the court gave a ruling with a dictum that the plaintiff's lawsuit was unacceptable because it was considered that the plaintiff's lawsuit was obscure lible. From this description, the researcher is interested in studying the decisions of religious courts and the review of procedural law in religious courts.