bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skeletal muscle mitochondrial volume and myozenin-1 protein differences exist between high versus low anabolic responders to resistance training
Authors: Roberts Michael D. , Romero Matthew A. , Mobley Christopher B. , Mumford Petey W. , Roberson Paul A. , Haun Cody T. , Vann Christopher G. , Osburn Shelby C. , Holmes Hudson H. , Greer Rory A. , Lockwood Christopher M. , Parry Hailey A. , Kavazis Andreas N. 
Published: July 2018

BackgroundWe sought to examine how 12 weeks of resistance exercise training (RET) affected skeletal muscle myofibrillar and sarcoplasmic protein levels along with markers of mitochondrial physiology in high versus low anabolic responders.MethodsUntrained college-aged males were classified as anabolic responders in the top 25th percentile (high-response cluster (HI);n= 13, dual x-ray absorptiometry total body muscle mass change (Δ) = +3.1 ± 0.3 kg, Δ vastus lateralis (VL) thickness = +0.59 ± 0.05 cm, Δ muscle fiber cross sectional area = +1,426 ± 253 μm2) and bottom 25th percentile (low-response cluster (LO);n= 12, +1.1 ± 0.2 kg, +0.24 ± 0.07 cm, +5 ± 209 μm2;p< 0.001 for all Δ scores compared to HI). VL muscle prior to (PRE) and following RET (POST) was assayed for myofibrillar and sarcoplasmic protein concentrations, myosin and actin protein content, and markers of mitochondrial volume. Proteins related to myofibril formation, as well as whole lysate PGC1-α protein levels were assessed.ResultsMain effects of cluster (HI > LO,p= 0.018, Cohen’sd= 0.737) and time (PRE > POST,p= 0.037, Cohen’sd= −0.589) were observed for citrate synthase activity, although no significant interaction existed (LO PRE = 1.35 ± 0.07 mM/min/mg protein, LO POST = 1.12 ± 0.06, HI PRE = 1.53 ± 0.11, HI POST = 1.39 ± 0.10). POST myofibrillar myozenin-1 protein levels were up-regulated in the LO cluster (LO PRE = 0.96 ± 0.13 relative expression units, LO POST = 1.25 ± 0.16, HI PRE = 1.00 ± 0.11, HI POST = 0.85 ± 0.12; within-group LO increasep= 0.025, Cohen’sd= 0.691). No interactions or main effects existed for other assayed markers.DiscussionOur data suggest myofibrillar or sarcoplasmic protein concentrations do not differ between HI versus LO anabolic responders prior to or following a 12-week RET program. Greater mitochondrial volume in HI responders may have facilitated greater anabolism, and myofibril myozenin-1 protein levels may represent a biomarker that differentiates anabolic responses to RET. However, mechanistic research validating these hypotheses is needed.
Realization of a New Topological Crystalline Insulator and Lifshitz Transition in PbTe
Authors: Ma Songsong , Guo Chunyu , Xiao Chengcheng , Wu Fan , Smidman Michael , Lu Yunhao , Yuan Huiqiu , Wu Huizhen 
Published: July 2018

AbstractTopological materials boast exotic metallic surface states with linear dispersion and spin‐momentum locking, which makes them potential candidates for dissipationless electronic and spintronic devices. Here, it is theoretically predicted that intrinsic Te antisite defects (TePb) in the narrow‐gap semiconductor PbTe induce a band inversion, turning it into a topological crystalline insulator (TCI). To experimentally verify the exotic properties, TePb antisites are introduced into PbTe crystals via nonstoichiometric growth by molecular beam epitaxy. Semimetallic resistivity and distinct quantum oscillations are observed on the TePb doped PbTe. Most importantly, a π Berry phase is unambiguously revealed by a Landau index analysis, demonstrating the Dirac fermion nature of the topological surface states. The discovered TCI nature in TePb doped PbTe is further explored using magneto‐transport measurements under external pressure, and the theoretical calculations of band structures with applying pressure indicate a pressure‐induced Lifshitz transition. Besides, it is proposed that the contribution of bulk states to transport can be reduced by enlarging the inverted gap with strain.
Flexible Ti3C2Tx@Al electrodes with Ultrahigh Areal Capacitance: In Situ Regulation of Interlayer Conductivity and Spacing
Authors: Guo Miao , Liu Chengbin , Zhang Zezhong , Zhou Jian , Tang Yanhong , Luo Shenglian 
Published: July 2018

AbstractAlthough Ti3C2 MXene has shown great potential in energy storage field, poor conductivity and restacking between MXene flakes seriously hinders the maximization of its capacitance. Herein, a new strategy to solve the problems is developed. Gallery Al atoms in Ti3AlC2 are partially removed by simple hydrothermal etching to get Ti3C2Tx reserving appropriate Al interlayers (Ti3C2Tx@Al). Ti3C2Tx@Al keeps stable layered structure rather than isolated Ti3C2Tx flakes, which avoids flake restacking. The removal of partial Al frees up space for easy electrolyte infiltration while the reserved Al as “electron bridges” ensures high interlayer conductivity. As a result, the areal capacitance reaches up to 1087 mF cm−2 at 1 mA cm−2 and over 95% capacitance is maintained after 6000 cycles. The all‐solid‐state supercapacitor (ASSS) based on Ti3C2Tx@Al delivers a high capacitance of 242.3 mF cm−2 at 1 mV s−1 and exhibits stable performance at different bending states. Two ASSSs in tandem can light up a light‐emitting diode under the planar or wrapping around an arm. The established strategy provides a new avenue to improve capacitance performances of MXenes.
Functionalization of Graphene Oxide Films with Au and MoOx Nanoparticles as Efficient p‐Contact Electrodes for Inverted Planar Perovskite Solar Cells
Authors: Bhosale Sumit S. , Jokar Efat , Fathi Amir , Tsai Cheng‐Min , Wang Chi‐Yung , Diau Eric Wei‐Guang 
Published: July 2018

AbstractA graphene oxide (GO) film is functionalized with metal (Au) and metal‐oxide (MoOx) nanoparticles (NPs) as a hole‐extraction layer for high‐performance inverted planar‐heterojunction perovskite solar cells (PSCs). These NPs can increase the work function of GO, which is confirmed with X‐ray photoelectron spectra, Kelvin probe force microscopy, and ultraviolet photoelectron spectra measurements. The down‐shifts of work functions lead to a decreased level of potential energy and hence increased Voc of the PSC devices. Although the GO‐AuNP film shows rapid hole extraction and increased Voc, a Jsc improvement is not observed because of localization of the extracted holes inside the AuNP that leads to rapid charge recombination, which is confirmed with transient photoelectric measurements. The power conversion efficiency (PCE) of the GO‐AuNP device attains 14.6%, which is comparable with that of the GO‐based device (14.4%). In contrast, the rapid hole extraction from perovskite to the GO‐MoOx layer does not cause trapping of holes and delocalization of holes in the GO film accelerates rapid charge transfer to the indium tin oxide substrate; charge recombination in the perovskite/GO‐MoOx interface is hence significantly retarded. The GO‐MoOx device consequently shows significantly enhanced Voc and Jsc, for which its device performance attains PCE of 16.7% with great reproducibility and enduring stability.
A Wrinkled PEDOT:PSS Film Based Stretchable and Transparent Triboelectric Nanogenerator for Wearable Energy Harvesters and Active Motion Sensors
Authors: Wen Zhen , Yang Yanqin , Sun Na , Li Gengfei , Liu Yina , Chen Chen , Shi Jihong , Xie Lingjie , Jiang Hongxue , Bao Dequan , Zhuo Qiqi , Sun Xuhui 
Published: July 2018

AbstractThe functionalized conductive polymer is a promising choice for flexible triboelectric nanogenerators (TENGs) for harvesting human motion energy still poses challenges. In this work, a transparent and stretchable wrinkled poly(3,4‐ethylenedioxythiophene):poly(4‐styrenesulfonate) (PEDOT:PSS) electrode based TENG (WP‐TENG) is fabricated. The optimum conductivity and transparency of PEDOT:PSS electrode can reach 0.14 kΩ □−1 and 90%, respectively, with maximum strain of ≈100%. Operating in single‐electrode mode at 2.5 Hz, the WP‐TENG with an area of 6 × 3 cm2 produces an open‐circuit voltage of 180 V, short‐circuit current of 22.6 µA, and average power density of 4.06 mW m−2. It can be worn on the wrist to harvest hand tapping energy and charge the capacitor to 2 V in ≈3.5 min, and then drive an electronic watch. Furthermore, the WP‐TENG as the human motion monitoring sensor could inspect the bending angle of the elbow and joint by analyzing the peak value of voltage and monitor the motion frequency by counting the peak number. The triboelectric mechanism also enables the WP‐TENG to realize high‐performance active tactile sensing. The assembled 3 pixel × 3 pixel tactile sensor array is fabricated for mapping the touch location or recording the shape of object contacted with the sensor array.
Prevention of Type 1 Diabetes with Acetalated Dextran Microparticles Containing Rapamycin and Pancreatic Peptide P31
Authors: Chen Naihan , Kroger Charles J. , Tisch Roland M. , Bachelder Eric M. , Ainslie Kristy M. 
Published: July 2018

AbstractType 1 diabetes (T1D) is a common autoimmune disease with no cure. T1D subjects are dependent on daily exogenous insulin administration, due to the loss of functional insulin‐producing β cells. Needed are immunotherapies that prevent and/or treat T1D. One approach of immunotherapy is to administer an autoantigen to selectively tolerize diabetogenic effector T cells without global immunosuppression. To date, however, strategies of antigen‐specific immunotherapy are largely ineffective in the clinic. Using an antigen‐specific approach, a biodegradable polymeric delivery vehicle, acetalated dextran microparticles (Ace‐DEX MPs), is applied and T1D development is prevented through coadministration of the immunosuppressant rapamycin and the diabetogenic peptide P31 (Rapa/P31/MPs), via alterations of both innate and adaptive immunity. Ex vivo, adoptively transferred CD4+ T cells exhibit reduced proliferation and an increased ratio of FoxP3+ to IFNγ+ T cells. In vitro analysis indicates dendritic cells exhibit a less mature phenotype following coculture with Rapa/P31/MPs, which results in reduced CD4+ T cell proliferation and proinflammatory cytokine production (IFNγ and IL‐2), but promotes PD‐1 expression. Together these results demonstrate Ace‐DEX MP‐based antigen‐specific therapy effectively tolerizes diabetogenic CD4+ T cells to prevent T1D, thereby demonstrating one of the first successful attempts of T1D prevention using a single‐formulation particulate delivery platform.
Printable Graphene Oxide Micropatterns for a Bio‐Subretinal Chip
Authors: Yang Jia‐Wei , Tseng Ming‐Liang , Fu Yu‐Min , Kang Che‐Hao , Cheng Yu‐Ting , Kuo Po‐Han , Tzeng Chi‐Kuan , Chiou Shih‐Hwa , Wu Chung‐Yu , Chen Guan‐Yu 
Published: July 2018

AbstractRecently, implantable artificial subretinal chips using electronic components have replaced photoreceptors to serve as the most feasible treatment for retinal diseases. As such a chip that is meant to be implanted and used for very long periods, growing retinal cells on it to improve the electrical stimulation efficiency and attraction of neuronal elements remains a challenge. Here, an inkjet printing technology is employed to create graphene oxide (GO) micropatterns onto microelectrodes of a photovoltaic‐powered implantable retinal chip. These GO micropatterns allow human retinal pigment epithelium (RPE) cells to specially attach and grow in each microelectrode. In addition, the cell proliferation, viability, and tight junction of RPE cells are improved during culturing. The development of a simple surface‐coating technology would pave the way for the development of the first fully integrated and encapsulated retinal prostheses with biocompatible on‐chip microelectrodes for long‐term implantation, which could be effectively applied in retina tissue engineering and therapy.
Near‐Infrared II Dye‐Protein Complex for Biomedical Imaging and Imaging‐Guided Photothermal Therapy
Authors: Zeng Xiaodong , Xiao Yuling , Lin Jiacheng , Li Shanshan , Zhou Hui , Nong Jinxia , Xu Guozhen , Wang Hongbo , Xu Fuchun , Wu Junzhu , Deng Zixin , Hong Xuechuan 
Published: July 2018

AbstractThe development of novel biodegradable and nontoxic fluorophores that integrate diagnosis and therapy for effective cancer treatment has obtained tremendous attention in the past decades. In this report, water‐soluble and biocompatible small‐molecule near‐infrared II (NIR‐II) fluorescent dye H2a‐4T complexed with fetal bovine serum (FBS) and Cetuximab proteins with excellent optical properties and targeting ability is prepared. High spatial and temporal resolution imaging of hind limb vasculature and the lymphatic system of living mice using H2a‐4T@FBS complex is demonstrated in precise NIR‐II imaging‐guided sentinel lymph node surgery. More importantly, H2a‐4T@Cetuximab complex not only exhibits a remarkable cell‐killing ability but also achieves highly active tumor targeting efficiency for epidermal growth factor receptor, overexpressing colorectal cancer which is beneficial to in vivo NIR‐II fluorescent imaging‐guided photothermal therapy of colon tumors. To the best of our knowledge, it is the first time that the concept of light‐harvesting complex is exploited for enhancing the NIR‐II signals and photothermal energy conversion in molecule‐protein complex theranostic agent, making them a promising candidate for future clinical applications in cancer theranostics.
Strategies toward Stable Perovskite Solar Cells
Authors: Wang Qiong , Abate Antonio 
Published: July 2018

AbstractSeveral strategies are proposed and implemented to improve the stability of perovskite solar cells (PSCs). The authors separate strategies toward stable PSCs according to the long‐term, hundreds of hours, and short‐term, minutes to hours, stability issue encountered in the operation of PSCs under standard working condition—light and load. To enhance the long‐term stability, the authors can rely on technological solutions such as encapsulation of the full device, application of hydrophobic hole selective materials, insertion of a polymer layer on top of perovskite film and enhancement of the intrinsic stability of perovskite material itself via tuning the composition. For the short‐term stability, which is mainly linked to formation and migration of ionic defects within the perovskite, bulk and interface passivation of perovskite film are demonstrated to be critically important. This article summarizes and analyzes the most recent updated strategies that are progressing PSCs toward commercialization.
Microcompartments with Strong and Dynamic Self‐Repairing Shells
Authors: Moore David G. , Moser Thierry A. , Rühs Patrick A. , Studart André R. 
Published: July 2018

AbstractMicrocompartments are useful for the storage, controlled reaction, and release of active compounds. However, the useful lifetime of a microcompartment is generally ended when it ruptures. Here, a self‐repairing microcompartment is proposed whose dynamic polymer shell can seal after rupturing, thus extending the lifetime of the capsule and allowing for multiple mechanically‐stimulated release events. The dynamic polymer shell is created in a one‐step approach through the formation of a double network polymer in the oil phase of a double emulsion template made by microfluidics. Of the two networks, a permanently‐crosslinked network is introduced to elastically restore the shape of the microcompartment, while a dynamically‐crosslinked network forms new bonds across crack interfaces. By quantifying the timescales required for the formation of new dynamic bonds within ruptured shells, strong microcompartments with predictable strength recovery and self‐repairing capabilities are successfully prepared and used to demonstrate the possibility of mechanically‐stimulated multiple release of cargo molecules.
Highly Permeable, Directional Water Transport Cotton Fabrics
Authors: Wang Hongxia , Zhou Hua , Wei Xin , Niu Haitao , Lin Tong 
Published: July 2018

AbstractA novel concept of preparing directional water transport cotton fabrics with high air permeability even if at a fully wetted state is demonstrated here. A two‐step electrospraying technique is employed to form a superhydrophobic pattern array on cotton fabric at the first step followed by single‐side electrospray treatment. The superhydrophobic pattern plays key roles not only in maintaining the cotton fabric at a high air permeability in wet state but also in enhancing one‐way transport capacity. In comparison to the single side electrosprayed fabric, which shows directional water transport property without superhydrophobic pattern, the one with a superhydrophobic pattern has 1.89 times higher one‐way transport index, whereas its air permeability is just reduced by 1.8% when it is wetted with water. This novel concept may be useful for design of high performance moisture management fabrics for various applications.
Janus Structural Color from a 2D Photonic Crystal Hybrid with a Fabry–Perot Cavity
Authors: Li Chang , Zhao Maoxiong , Zhou Xue , Li Huizeng , Wang Yang , Hu Xiaotian , Li Mingzhu , Shi Lei , Song Yanlin 
Published: July 2018

AbstractStructural colors are widely applied for their stability and their sophisticated optical responses. However, these colors always appear washed‐out or pale assigning to the defect hardly avoided in the manufacturing procedures. It is still a challenge to bring multifunctional vivid color via a facile method. A composite structure combining 2D photonic crystal and Fabry–Perot cavity by a simple and convenient method is constructed here. Various metallic colors with tunable hue and high saturation are produced by the composite structure. What is more, an obvious optical Janus effect is created by the composite structure. Iridescent colors can be observed when viewing from the same side of incident light but only pale colors can be seen from the opposite side. The hues and saturation of the colors can be adjusted by the parameters of the composite structure. The experimental results indicate that the color is derived from the synergistic effect of the interference, the diffraction, and the Rayleigh scattering of the composite structure. The facile composite photonic structure pioneers a new way for art, architecture, and security features in anticounterfeiting materials.
Syntheses of Lactams by Tandem Reactions
Authors: Meazza Marta , Companyó Xavier , Rios Ramon 
Published: July 2018

AbstractTandem reactions form two or more new bonds, sequentially and in only one step, avoiding the purification of each step and the use of protecting groups, thus making them greener procedures. Lactams are cyclic amides present in numerous natural products and pharmaceuticals, therefore the development of new methodologies for their synthesis attracted the attention of synthetic chemists. The aim of this review is to summarize the last advances, since 2012, in the synthesis of lactams through tandem reactions.
High‐Frequency Oscillations in the Normal Human Brain
Authors: Frauscher Birgit , von Ellenrieder Nicolás , Zelmann Rina , Rogers Christine , Nguyen Dang Khoa , Kahane Philippe , Dubeau François , Gotman Jean 
Published: July 2018

ObjectiveHigh‐frequency oscillations (HFOs) are a promising biomarker for the epileptogenic zone. It has not been possible, however, to differentiate physiological from pathological HFOs, and baseline rates of HFO occurrence vary substantially across brain regions. This project establishes region‐specific normative values for physiological HFOs and high‐frequency activity (HFA).MethodsIntracerebral stereo‐encephalographic recordings with channels displaying normal physiological activity from nonlesional tissue were selected from 2 tertiary epilepsy centers. Twenty‐minute sections from N2/N3 sleep were selected for automatic detection of ripples (80–250Hz), fast ripples (>250Hz), and HFA defined as long‐lasting activity > 80Hz. Normative values are provided for 17 brain regions.ResultsA total of 1,171 bipolar channels with normal physiological activity from 71 patients were analyzed. The highest rates of ripples were recorded in the occipital cortex, medial and basal temporal region, transverse temporal gyrus and planum temporale, pre‐ and postcentral gyri, and medial parietal lobe. The mean rate of fast ripples was very low (0.038/min). Only 5% of channels had a rate > 0.2/min HFA was observed in the medial occipital lobe, pre‐ and postcentral gyri, transverse temporal gyri and planum temporale, and lateral occipital lobe.InterpretationThis multicenter atlas is the first to provide region‐specific normative values for physiological HFO rates and HFA in common stereotactic space; rates above these can now be considered pathological. Physiological ripples are frequent in eloquent cortex. In contrast, physiological fast ripples are very rare, making fast ripples a good candidate for defining the epileptogenic zone. Ann Neurol 2018;84:374–385
[FeFe]‐Hydrogenase Mimetic Metallopolymers with Enhanced Catalytic Activity for Hydrogen Production in Water
Authors: Brezinski William P. , Karayilan Metin , Clary Kayla E. , Pavlopoulos Nicholas G. , Li Sipei , Fu Liye , Matyjaszewski Krzysztof , Evans Dennis H. , Glass Richard S. , Lichtenberger Dennis L. , Pyun Jeffrey 
Published: July 2018

AbstractElectrocatalytic [FeFe]‐hydrogenase mimics for the hydrogen evolution reaction (HER) generally suffer from low activity, high overpotential, aggregation, oxygen sensitivity, and low solubility in water. By using atom‐transfer radical polymerization (ATRP), a new class of [FeFe]‐metallopolymers with precise molar mass, defined composition, and low polydispersity, has been prepared. The synthetic methodology introduced here allows facile variation of polymer composition to optimize the [FeFe] solubility, activity, and long‐term chemical and aerobic stability. Water soluble functional metallopolymers facilitate electrocatalytic hydrogen production in neutral water with loadings as low as 2 ppm and operate at rates an order of magnitude faster than hydrogenases (2.5×105 s−1), and with low overpotential requirement. Furthermore, unlike the hydrogenases, these systems are insensitive to oxygen during catalysis, with turnover numbers on the order of 40 000 under both anaerobic and aerobic conditions.
Quantifying the Thermodynamics of Ligand Binding to CsPbBr3 Quantum Dots
Authors: Smock Sara R. , Williams Travis J. , Brutchey Richard L. 
Published: July 2018

AbstractCesium lead halide perovskites are an emerging class of quantum dots (QDs) that have shown promise in a variety of applications; however, their properties are highly dependent on their surface chemistry. To this point, the thermodynamics of ligand binding remain unstudied. Herein, 1H NMR methods were used to quantify the thermodynamics of ligand exchange on CsPbBr3 QDs. Both oleic acid and oleylamine native ligands dynamically interact with the CsPbBr3 QD surface, having individual surface densities of 1.2–1.7 nm−2. 10‐Undecenoic acid undergoes an exergonic exchange equilibrium with bound oleate (Keq=1.97) at 25 °C while 10‐undecenylphosphonic acid undergoes irreversible ligand exchange. Undec‐10‐en‐1‐amine exergonically exchanges with oleylamine (Keq=2.52) at 25 °C. Exchange occurs with carboxylic acids, phosphonic acids, and amines on CsPbBr3 QDs without etching of the nanocrystal surface; increases in the steady‐state PL intensities correlate with more strongly bound conjugate base ligands.