bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient and Tunable Electroluminescence from In Situ Synthesized Perovskite Quantum Dots
Authors: Yu Hongling , Wang Heyong , Zhang Jiangbin , Lu Jun , Yuan Zhongcheng , Xu Weidong , Hultman Lars , Bakulin Artem A. , Friend Richard H. , Wang Jianpu , Liu Xiao‐Ke , Gao Feng 
Published: January 2019

AbstractSemiconductor quantum dots (QDs) are among the most promising next‐generation optoelectronic materials. QDs are generally obtained through either epitaxial or colloidal growth and carry the promise for solution‐processed high‐performance optoelectronic devices such as light‐emitting diodes (LEDs), solar cells, etc. Herein, a straightforward approach to synthesize perovskite QDs and demonstrate their applications in efficient LEDs is reported. The perovskite QDs with controllable crystal sizes and properties are in situ synthesized through one‐step spin‐coating from perovskite precursor solutions followed by thermal annealing. These perovskite QDs feature size‐dependent quantum confinement effect (with readily tunable emissions) and radiative monomolecular recombination. Despite the substantial structural inhomogeneity, the in situ generated perovskite QDs films emit narrow‐bandwidth emission and high color stability due to efficient energy transfer between nanostructures that sweeps away the unfavorable disorder effects. Based on these materials, efficient LEDs with external quantum efficiencies up to 11.0% are realized. This makes the technologically appealing in situ approach promising for further development of state‐of‐the‐art LED systems and other optoelectronic devices.
Locally Trapping the C‐C Chemokine Receptor Type 7 by Gene Delivery Nanoparticle Inhibits Lymphatic Metastasis Prior to Tumor Resection
Authors: An Sai , Tiruthani Karthik , Wang Ying , Xu Ligeng , Hu Mengying , Li Jingjing , Song Wantong , Jiang Hongnan , Sun Jirui , Liu Rihe , Huang Leaf 
Published: January 2019

AbstractTriple negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Currently, no targeted treatment is available for TNBC, and the most common clinical therapy is tumor resection, which often promotes metastasis risks. Strong evidence suggests that the lymphatic metastasis is mediated by the C‐C chemokine receptor type 7 (CCR7)/C‐C motif chemokine ligand 21 crosstalk between tumor cells and the lymphatic system. It is hypothesized that CCR7 is a key immune modulator in the tumor microenvironment and the local blockade of CCR7 could effectively inhibit TNBC lymphatic metastasis. Accordingly, a plasmid encoding an antagonistic CCR7 affinity protein‐CCR7 trap is delivered by tumor targeting nanoparticles in a highly metastatic 4T1 TNBC mouse model. Results show that CCR7 traps are transiently expressed, locally disrupt the signaling pathways in the tumor site, and efficiently inhibit TNBC lymphatic metastasis, without inducing immunosuppression as observed in systemic therapies using CCR7 monoclonal antibody. Significantly, upon applying CCR7 trap therapy prior to tumor resection, a 4T1 TNBC mouse model shows good prognosis without any further metastasis and relapse. In addition, CCR7 trap therapy efficiently inhibits the lymphatic metastasis in a B16F10 melanoma mouse model, indicating its great potential for various metastatic diseases treatment.
Super‐Stable, Highly Efficient, and Recyclable Fibrous Metal–Organic Framework Membranes for Precious Metal Recovery from Strong Acidic Solutions
Authors: Liu Yang , Lin Shuo , Liu Yanan , Sarkar Amit Kumar , Bediako John Kwame , Kim Hak Yong , Yun Yeoung‐Sang 
Published: January 2019

AbstractPrecious metals such as palladium (Pd) and platinum (Pt) are marvelous materials in the fields of electronic and catalysis, but they are tapering day by day. Zr(IV)‐based metal–organic frameworks (MOFs) are competent for their recovery, notably in harsh environments, while the general powder form limits their practical application. Porous MOF‐based membranes with ultraefficient metal ion permeation, strong stability, and high selectivity are, therefore, strikingly preferred. Herein, a set of polymeric fibrous membranes incorporated with the UiO‐66 series are fabricated; their adsorption/desorption capabilities toward Pd(II) and Pt(IV) are evaluated from strongly acidic solutions; and the MOF–polymer compatibilities are investigated. Polyurethane (PU)/UiO‐66‐NH2 showed strong acid resistance and high chemical stability, which are attributable to strong π–π interactions between PU and MOF nanoparticles with a high configuration of energy. The as‐fabricated MOF membranes show extremely good adsorption/desorption performances without ruptures/coalitions of nanofibers or leak of MOF nanoparticles, and successfully display the efficacy in a gravity‐driven or even continuous‐flow system with good recycle performance and selectivity. The as‐fabricated MOF membranes set an example of potential MOF–polymer compatibility for practical applications.
Teachers' framing of argumentation goals: Working together to develop individual versus communal understanding
Authors: González‐Howard María , McNeill Katherine L. 
Published: January 2019

AbstractFor students to meaningfully engage in science practices, substantive changes need to occur to deeply entrenched instructional approaches, particularly those related to classroom discourse. Because teachers are critical in establishing how students are permitted to interact in the classroom, it is imperative to examine their role in fostering learning environments in which students carry out science practices. This study explores how teachers describe, or frame, expectations for classroom discussions pertaining to the science practice of argumentation. Specifically, we use the theoretical lens of a participation framework to examine how teachers emphasize particular actions and goals for their students' argumentation. Multiple‐case study methodology was used to explore the relationship between two middle school teachers' framing for argumentation, and their students' engagement in an argumentation discussion. Findings revealed that, through talk moves and physical actions, both teachers emphasized the importance of students driving the argumentation and interacting with peers, resulting in students engaging in various types of dialogic interactions. However, variation in the two teachers' language highlighted different purposes for students to do so. One teacher explained that through these interactions, students could learn from peers, which could result in each individual student revising their original argument. The other teacher articulated that by working with peers and sharing ideas, classroom members would develop a communal understanding. These distinct goals aligned with different patterns in students' argumentation discussion, particularly in relation to students building on each other's ideas, which occurred more frequently in the classroom focused on communal understanding. The findings suggest the need to continue supporting teachers in developing and using rich instructional strategies to help students with dialogic interactions related to argumentation. This work also sheds light on the importance of how teachers frame the goals for student engagement in this science practice.
Ultimate load design of jacket‐type offshore wind turbines under tropical cyclones
Authors: Ju Shen‐Haw , Su Feng‐Chien , Jiang Yao‐Ting , Chiu Yu‐Chuan 
Published: January 2019

AbstractTropical cyclones are a high risk to offshore wind turbine (OWT) support structures, so the design conditions, including this risk, are necessary for tropical cyclone frequent occurrence zones. This study developed a computer program to carry out a critical ultimate load analysis and determine the optimum design for a Jacket‐type OWT support structure. The total weight of the OWT support structure after the optimal steel design with the yaw operative condition is always considerably smaller than that without for the steel design results under the loads of the GL Tropical Cyclone Technical Note (GL TCTN). This paper studies OWTs under the tropical cyclone classes 1 to 3 and the terrain categories A, to C, where the 1‐minute wind speed at 10‐m height is gradually increased from classes 1 to 3, and the surface roughness decreases from A to C. When the yaw can operate, the total steel weight consumption due to the tropical cyclone 1C, 1B, and 2C loads is lower than that for the IEC 61400‐3 loads. In the case of 1A, the overall steel consumption is only slightly higher than that of the IEC 61400‐3. However, for other conditions, the design should include the GL TCTN loads. For the yaw inoperative condition, the GL TCTN results are always largely dominant in the steel design, so the use of only the IEC 61400‐3 condition will result in extremely high risk to OWT support structures.
Thermodynamic equilibrium predictions of zinc volatilization, migration, and transformation during sludge co‐incineration
Authors: Liu Jingyong , Cai Haiming , Wu Shijun , Dang Xiaoe , Buyukada Musa , Evrendilek Fatih 
Published: January 2019

AbstractThe effects of interactions between and among chlorine (Cl), sulfur (S), phosphorus (P), and minerals on migration, transformation, and volatilization of zinc (Zn) were numerically simulated in sludge co‐incineration using the chemical thermodynamic equilibrium method. Our results showed that all the minerals of Fe2O3, Al2O3, Fe2O3, and TiO2 except for CaO in the sludge co‐incineration system reacted with Zn which inhibited the Zn volatilization. The presence of S and P was beneficial to the formation of ZnSO4(s) and Zn3(PO4)2(s). Cl weakened the chemical reactions between the minerals and Zn, thus increasing the Zn volatilization. Changes in Zn transformation and migration induced by the coupling of Cl + S were mainly controlled by Cl, S, and the minerals, while those induced by Cl + P and S + P were mainly controlled by P and S + P. The presence of P + Cl, S + Cl, S + P, S + Cl + P, Cl, and Al2O3 in the coexisting mineral system controlled the reactions between the minerals and Zn.
Impacts of solids retention time and antibiotic loading in activated sludge systems on secondary effluent water quality and microbial community structure
Authors: Gerrity Daniel , Neyestani Majid 
Published: January 2019

AbstractSolids retention time (SRT) is one of the most important factors in designing and operating activated sludge systems for biological wastewater treatment. Longer SRTs have been shown to alter the structure and function of microbial communities, thereby leading to improved treatment efficacy with respect to bulk and trace organics, nutrient removal, and membrane fouling. Research has also shown that longer SRTs and/or higher influent antibiotic concentrations may lead to increased prevalence of antibiotic resistance. However, it is unclear whether elevated, yet subclinical, concentrations of antibiotics also impact the overall microbial community. The purpose of this study was to characterize changes in microbial community structure in a laboratory‐scale activated sludge system as a function of SRT (2–20 days) and influent concentrations (1×–100× ambient) of ampicillin, sulfamethoxazole, tetracycline, trimethoprim, and vancomycin. Changes in microbial community structure were evaluated based on 16S rRNA gene sequencing, and microbial community function was evaluated based on changes in effluent water quality, including attenuation of bulk and trace organics. The results confirmed that longer SRTs—but not antibiotic loadings—had a significant impact on microbial community structure and effluent water quality. Therefore, moderate spikes in influent antibiotic concentrations are not expected to adversely impact biological wastewater treatment.Practitioner points

Longer SRTs lead to changes in microbial community structure, including alpha and beta diversity and relative abundance of various taxa.

Enhanced TOrC attenuation at longer SRTs may be linked to biomass abundance rather than changes in microbial community structure.

Moderate spikes in influent antibiotic concentrations do not impact activated sludge performance or microbial community structure.

The phyla Proteobacteria and Bacteroidetes comprise a majority of the microbial community in primary effluent and mixed liquor.
Computational methods and applications for quantitative systems pharmacology
Authors: Xie Fuda , Gu Jiangyong 
Published: January 2019

BackgroundQuantitative systems pharmacology (QSP) is an emerging discipline that integrates diverse data to quantitatively explore the interactions between d
rugs and multi‐scale systems including small compounds, nucleic acids, proteins, pathways, cells, organs and disease processes.ResultsVarious computational methods such as ADME/T evaluation, molecular modeling, logical modeling, network modeling, pathway analysis, multi‐scale systems pharmacology platforms and virtual patient for QSP have been developed. We reviewed the major progresses and broad applications in medical guidance, drug discovery and exploration of pharmacodynamic material basis and mechanism of traditional Chinese medicine.ConclusionQSP has significant achievements in recent years and is a promising approach for quantitative evaluation of drug efficacy and systematic exploration of mechanisms of action of drugs.
Regular variation in a fixed-point problem for single- and multi-class branching processes and queues
Authors: Asmussen Søren , Foss Sergey 
Published: February 2019

Abstract
Tail asymptotics of the solution R to a fixed-point problem of the type R=DQ+∑1NRm are derived under heavy-tailed conditions allowing both dependence between Q and N and the tails to be of the same order of magnitude. Similar results are derived for a K-class version with applications to multi-type branching processes and busy periods in multi-class queues.
Weakly nonlinear transient waves on a shear current: ring waves and skewed Langmuir rolls
Authors: Akselsen Andreas H. , Ellingsen Simen Å. 
Published: January 2019

We investigate the weakly nonlinear dynamics of transient gravity waves at infinite depth under the influence of a shear current varying linearly with depth. The shear field makes this problem three-dimensional and rotational in nature, but an analytical solution is permitted via integration of the Euler equations. Although similar problems were investigated in the 1960s and 70s for special cases of resonance, this is to our knowledge the first general wave interaction (mode coupling) solution derived to second order with a shear current present. Wave interactions are integrable in a spectral convolution to yield the second-order dynamics of initial value problems. To second order, irrotational wave dynamics interacts with the background vorticity field in a way that creates new vortex structures. A notable example is the large parallel vortices which drive Langmuir circulation as oblique plane waves interact with an ocean current. We also investigate the effect on wave pairs which are misaligned with the shear current to find that similar, but skewed, vortex structures are generated in every case except when the mean wave direction is precisely perpendicular to the direction of the current. This is in contrast to a conjecture by Leibovich (Annu. Rev. Fluid Mech., vol. 15, 1983, pp. 391–427). Similar nonlinear wave–shear interactions are found to also generate near-field vortex structures in the Cauchy–Poisson problem with an initial surface elevation. These interactions create further groups of dispersive ring waves in addition to those present in linear theory. The second-order solution is derived in a general manner which accommodates any initial condition through mode coupling over a continuous wave spectrum. It is therefore applicable to a range of problems including special cases of resonance. As a by-product of the general theory, a simple expression for the Stokes drift due to a monochromatic wave propagating at oblique angle with a current of uniform vorticity is derived, for the first time to our knowledge.
On the unsteady characteristics of turbulent separations over a forward–backward-facing step
Authors: Fang Xingjun , Tachie Mark F. 
Published: January 2019

Turbulent separation bubbles over and behind a two-dimensional forward–backward-facing step submerged in a deep turbulent boundary layer are investigated using a time-resolved particle image velocimetry. The Reynolds number based on the step height and free-stream velocity is 12 300, and the ratio of the streamwise length to the height of the step is 2.36. The upstream turbulent boundary layer thickness is 4.8 times the step height to ensure a strong interaction of the upstream turbulence structures with the separated shear layers over and behind the step. The velocity measurements were performed in streamwise–vertical planes at the channel mid-span and streamwise–spanwise planes at various vertical distances from the wall. The unsteady characteristics of the separation bubbles and their associated turbulence structures are studied using a variety of techniques including linear stochastic estimation, proper orthogonal decomposition and variable-interval time averaging. The results indicate that the low-frequency flapping motion of the separation bubble over the step is induced by the oncoming large-scale alternating low- and high-velocity streaky structures. Dual separation bubbles appear periodically over the step at a higher frequency than the flapping motion, and are attributed to the inherent instability in the rear part of the mean separation bubble. The separation bubble behind the step exhibits a flapping motion at the same frequency as the separation bubble over the step, but with a distinct phase delay. At instances when an enlarged separation bubble is formed in front of the step, a pair of vertical counter-rotating vortices is formed in the immediate vicinity of the leading edge.
What Can Instrumental Variables Tell Us About Nonresponse In Household Surveys and Political Polls?
Authors: Wing Coady 
Published: January 2019

This paper introduces an instrumental variables framework for analyzing how external factors that affect survey response rates can also affect the composition of the sample of respondents. The method may be useful for studying survey representativeness, and for assessing the effectiveness of some of the conventional corrections for survey nonresponse bias.The paper applies the method to data collected in the 2011 Swiss Electoral Study (SES), in which survey participation incentives were randomly assigned across members of the original survey sample. The empirical analysis shows that the incentives increased response rates substantially. Estimates of a new instrumental variable parameter called the Complier Average Survey Response (CASR) suggest that the incentives induced participation among people with more nationalist political opinions than those who would have participated without the incentives. Weighting the respondent data to match the covariate distribution in the target population did not account for the discrepancy in attitudes between the two groups, suggesting that the weights would not succeed in removing nonresponse bias.
Determinantal inequalities for the partition function
Authors: Jia Dennis X.Q. , Wang Larry X.W. 
Published: January 2019

AbstractLetp(n) denote the partition function. In this paper, we will prove that for$n\ges 222$,$$\left| {\matrix{ {p(n)} & {p(n + 1)} & {p(n + 2)} \cr {p(n-1)} & {p(n)} & {p(n + 1)} \cr {p(n-2)} & {p(n-1)} & {p(n)} \cr } } \right| > 0.{\rm }$$As a corollary, we deduce thatp(n) satisfies the double Turán inequalities, that is, for$n\ges 222$,$$(p(n)^2-p(n-1)p(n+1))^2-(p(n-1)^2-p(n-2)p(n))(p(n+1)^2-p(n)p(n+2))>0.$$
Liouville-type theorems and existence results for stable solutions to weighted Lane–Emden equations
Authors: Farina Alberto , Hasegawa Shoichi 
Published: January 2019

AbstractWe devote this paper to proving non-existence and existence of stable solutions to weighted Lane-Emden equations on the Euclidean space ℝN, N ⩾ 2. We first prove some new Liouville-type theorems for stable solutions which recover and considerably improve upon the known results. In particular, our approach applies to various weighted equations, which naturally appear in many applications, but that are not covered by the existing literature. A typical example is provided by the well-know Matukuma's equation. We also prove an existence result for positive, bounded and stable solutions to a large family of weighted Lane–Emden equations, which indicates that our Liouville-type theorems are somehow sharp.
On two cohomological Hall algebras
Authors: Yang Yaping , Zhao Gufang 
Published: January 2019

AbstractWe compare two cohomological Hall algebras (CoHA). The first one is the preprojective CoHA introduced in [19] associated with each quiver Q, and each algebraic oriented cohomology theory A. It is defined as the A-homology of the moduli of representations of the preprojective algebra of Q, generalizing the K-theoretic Hall algebra of commuting varieties of Schiffmann-Vasserot [15]. The other one is the critical CoHA defined by Kontsevich-Soibelman associated with each quiver with potentials. It is defined using the equivariant cohomology with compact support with coefficients in the sheaf of vanishing cycles. In the present paper, we show that the critical CoHA, for the quiver with potential of Ginzburg, is isomorphic to the preprojective CoHA as algebras. As applications, we obtain an algebra homomorphism from the positive part of the Yangian to the critical CoHA.
Adaption of body zinc pools in weaned piglets challenged with subclinical zinc deficiency
Authors: Brugger Daniel , Windisch Wilhelm M. 
Published: January 2019

AbstractThe effects of subclinical Zn deficiency on depletion and redistribution of body Zn were studied in weaned piglets. Forty-eight weaned piglets (German-Large-White×Land-Race×Piétrain; 50 % female, 50 % male-castrated; body weight 8·5 (sd0·27) kg) were fed restrictively (450 g/d) a basal maize–soyabean meal-based diet supplemented with varying amounts of ZnSO4.7H2O (analysed dietary Zn: 28·1, 33·6, 38·8, 42·7, 47·5, 58·2, 67·8, 88·0 mg/kg diet) for an experimental period of 8 d. Analyses comprised Zn concentrations in soft tissues. Statistical analyses included regression models andk-means cluster analysis. Jejunum and kidney Zn correlated positively with dietary Zn (P<0·05). Other Zn pools responded in a non-linear fashion by declining (colon, epidermis, spleen) or increasing (mesenteric lymph follicles, thymus, skeletal muscle) below 63·6, 48·0, 47·5, 68·0, 43·0 and 53·1 mg Zn/kg diet, respectively (P<0·01). Above these thresholds, Zn concentrations in epidermis, mesenteric lymph follicles and skeletal muscle plateaued (P<0·0001), whereas they exhibited a decrease in colon and thymus (P<0·01) as well as a numerical increase in spleen. Clustering by dietary Zn concentration indicated clusters of varying Zn supply status and pathophysiological status. Clustering by biological matrices revealed a discrimination between storage, transport and excretion media as well as soft tissues. Taken together, novel response patterns indicated compensation reactions in tissues that are essential for the acute survival of growing animals (heart, skeletal muscle, immune tissues). Furthermore, this is to our knowledge the first study that mapped the gross Zn requirement by clustering tissue Zn concentrations between treatment groups.