bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vivo Formation of Stable Hyaline Cartilage by Naïve Human Bone Marrow Stromal Cells with Modified Fibrin Microbeads
Authors: Kuznetsov Sergei A. , Hailu-Lazmi Astar , Cherman Natasha , Castro Luis F. , Robey Pamela G. , Gorodetsky Raphael 
Published: February 2019

Abstract
Osteoarthritic and other types of articular cartilage defects never heal on their own. Medicinal and surgical approaches are often ineffective, and the supply of autologous chondrocytes for tissue engineering is very limited. Bone marrow stromal cells (BMSCs, also known as bone marrow-derived mesenchymal stem cells) have been suggested as an adequate cell source for cartilage reconstruction. However, the majority of studies employing BMSCs for cartilage tissue engineering have used BMSCs predifferentiated into cartilage prior to implantation. This strategy has failed to achieve formation of stable, hyaline-like cartilage, resistant to hypertrophy in vivo. We hypothesized that in vitro predifferentiation of BMSCs is not necessary when cells are combined with an adequate scaffold that supports the formation of stable cartilage in vivo. In this study, naïve (undifferentiated) human BMSCs were attached to dehydrothermally crosslinked stable fibrin microbeads (FMBs) without and with other scaffolds and implanted subcutaneously into immunocompromised mice. Optimal formation of abundant, hypertrophy-resistant, ectopic hyaline-like cartilage was achieved when BMSCs were attached to FMBs covalently coated with hyaluronic acid. The cartilage that was formed was of human origin and was stable for at least 28 weeks in vivo. Stem Cells Translational Medicine 2019;8:586–592
Multishelled Transition Metal‐Based Microspheres: Synthesis and Applications for Batteries and Supercapacitors
Authors: Liu Yang , Li Xiangcun , Shen Weiming , Dai Yan , Kou Wei , Zheng Wenji , Jiang Xiaobin , He Gaohong 
Published: February 2019

AbstractWith the rapid growth of material innovations, multishelled hollow nanostructures are of tremendous interest due to their unique structural features and attractive physicochemical properties. Continued effort has been made in the geometric manipulation, composition complexity, and construction diversity of this material, expanding its applications. Energy storage technology has benefited from the large surface area, short transport path, and excellent buffering ability of the nanostructures. In this work, the general synthesis of multishelled hollow structures, especially with architecture versatility, is summarized. A wealth of attractive properties is also discussed for a wide area of potential applications based on energy storage systems, including Li‐ion/Na‐ion batteries, supercapacitors, and Li–S batteries. Finally, the emerging challenges and outlook for multishelled hollow structures are mentioned.
The inclusion of Acrophorus, Diacalpe, Nothoperanema, and Peranema in Dryopteris: The molecular phylogeny, systematics, and nomenclature of Dryopteris subg. Nothoperanema (Dryopteridaceae)
Authors: Zhang Li-Bing , Zhang Liang 
Published: February 2019

AbstractDryopteris (Dryopteridaceae) is one of the largest fern genera containing about 300 or more species. Sixty‐five accessions representing all four subgenera and all 19 sections of Dryopteris recognized in current classifications, more than two‐thirds of the species of Acrophorus, Diacalpe, Nothoperanema, and Peranema, three species of Arachniodes, three species of Cyrtomium, one species of Phanerophlebia, and two species of Polystichum, were sampled as ingroup in this study. Two species of Polystichopsis were used as outgroups. DNA sequences of five plastid loci (psbA‐trnH spacer, rbcL gene, rps4‐trnS spacer, trnL intron, trnL‐F spacer) were used to infer the phylogeny of Dryopteris and related genera. Our study clearly demonstrated that the currently defined Dryopteris is paraphyletic in relation to a clade containing the monophyletic Acrophorus, Diacalpe, Nothoperanema, and Peranema. Peranema is resolved as sister to the remaining three genera, followed by Nothoperanema which in turn is sister to the Acrophorus + Diacalpe clade, but this relationship received low support. Three out of the four subgenera of Dryopteris recognized in current classifications are not recovered as monophyletic. Dryopteris subg. Nothoperanema, well supported as monophyletic by molecular and morphological data, is resurrected and re‐circumscribed to contain species of the currently accepted genera Acrophorus, Diacalpe, Nothoperanema, and Peranema. Twenty‐seven species are recognized and classified into four sections based on molecular and morphological evidence. Included in this treatment are 25 new combinations, names, species, and statuses, and neotypification or lectotypification of 14 names. The present study further located and cited types of an additional 28 related names, many of which have been unknown to science. Keys to sections and species and distributional information are given and nomenclatural issues are discussed. This paper also synonymized and excluded 33 nomenclaturally confusing names of Dryopteris that were formerly assigned to Acrophorus or Diacalpe.
Delimitation of the genus Margaritopsis (Rubiaceae) in the Asian, Australasian and Pacific region, based on molecular phylogenetic inference and morphology
Authors: Barrabé Laure , Buerki Sven , Mouly Arnaud , Davis Aaron P. , Munzinger Jérôme , Maggia Laurent 
Published: February 2019

AbstractIn the past, the circumscription of the large genus Psychotria (Rubiaceae) was difficult, until molecular phylogenetic studies revealed its considerable paraphyly, enabling the delimitation of its major lineages and the grouping of related genera, and most notably the separation of Psychotria and its relatives (former Psychotrieae) into two tribes: Psychotrieae and Palicoureeae. The genus Margaritopsis, which is included in Palicoureeae, encompasses 27 Neotropical species, and in previous studies these have been shown to be close relatives of a group of eight Psychotria species that occur over a large region extending from South‐East Asia to tropical South Pacific through Malesia (= the AMP region, defined as including South‐East Asia, Malesia, tropical Australia, Melanesia, Micronesia, New Caledonia and Polynesia). A molecular phylogenetic study, using one nuclear DNA region (ITS) and four plastid DNA regions (ndhF, rps16, trnH‐psbA, trnT‐F), is undertaken in order to test the placement of 17 AMP Psychotria species within Palicoureeae. The phylogenetic results show that they form a monophyletic clade (= clade G), which also includes the monotypic Fijian genus Readea and Hodgkinsonia frutescens from Australia. Clade G is embedded in a well‐supported grade with five Neotropical representatives of Margaritopsis. A morphological survey based on twenty characters, with the potential to circumscribe generic entities, shows that the monophyly of clade G is supported by a character combination that is similar to species of Neotropical Margaritopsis, confirming their inclusion in this genus. Taxonomic and nomenclatural work on these species is required to formalize nomenclatural implications. Based on the same set of morphological characters, but in absence of molecular data, 28 other Psychotria species from the AMP region were detected as likely candidates for inclusion in Margaritopsis, allowing the estimation of species richness of clade G to be a minimum of 47 species. Within clade G, five well‐supported subclades and a Readea lineage are delimited and each of these is generally supported by unique morphological features. Phylogenetic topologies reveal biogeographical patterns, including a main route of dispersal from western to eastern parts of the AMP region, with subsequent dispersals between archipelagos in the region.
Phylogeny of tribe Rhinantheae (Orobanchaceae) with a focus on biogeography, cytology and re‐examination of generic concepts
Authors: Scheunert Agnes , Fleischmann Andreas , Olano-Marín Catalina , Bräuchler Christian , Heubl Günther 
Published: February 2019

AbstractA molecular systematic approach using DNA sequences of two non‐coding chloroplast loci (trnK, rps16) and the nuclear ITS region was applied to reconstruct phylogenetic relationships within the tribe Rhinantheae (Orobanchaceae). This tribe includes approximately 19 genera of hemiparasitic plants predominantly occurring in the Old World. An exception is the genus Bartsia which, according to previous taxonomic treatments, includes a remarkable radiation (ca. 45 species) in the Andes, two species distributed in Afromontane regions, and only one species (Bartsia alpina) ranging from the alpine mountains of northern and central Europe to northeastern North America. The present phylogenetic study includes the most comprehensive taxon sampling of Rhinantheae to date, with main focus on the relationships of the Mediterranean genera. Both nuclear and plastid datasets reveal a core group of Rhinantheae comprising four major lineages. Our analyses suggest that (1) the northern temperate Bartsia alpina is sister to the rest of the core group; (2) African Bartsia are more closely related to the monotypic African genus Hedbergia than to other congeneric taxa; (3) South American Bartsia are nested within a highly supported clade including Parentucellia and Bellardia; (4) Nothobartsia and Odontitella are likely to be the results of at least one intergeneric hybridization event. Despite topological conflicts regarding some taxa, the polyphyly of Bartsia and a broadly circumscribed Odontites are unambiguously supported by our results. Our tree topologies indicate that the importance of certain morphological characters traditionally used for generic delimitation (such as shape and indumentum of corolla, anthers, and capsules) has been overestimated, and that some of these characters are presumably convergent. Available information on chromosome numbers corroborates the results presented here.
Tribounia, a new genus of Gesneriaceae from Thailand
Authors: Middleton David J. , Möller Michael 
Published: February 2019

AbstractThe new genus Tribounia is described with two species, Tribounia venosa (Barnett) D.J. Middleton, a new combination, and Tribounia grandiflora D.J. Middleton, a new species. A key to the species and conservation assessments are provided.
Adjunctive kampo therapy for incomplete Kawasaki disease mimic associated with reaction at the bacillus Calmette–Guérin inoculation site
Authors: Takahashi Kazuhiro , Sato Yasumasa , Wakahara Atsushi , Nagase Tomoko , Masue Michiya 
Published: February 2019

ABSTRACTAimWe report two cases of incomplete Kawasaki disease (IKD) mimic associated with bacillus Calmette–Guérin (BCG) inoculation site reaction that were treated with Japanese traditional herbal (kampo) medicine, eppikajutsuto (EJT), as an adjunct to high‐dose oral acetylsalicylic acid in the early disease stage.ResultsPhysical findings, such as peripheral edematous erythema of the extremities and BCG site change in febrile infants, were strongly suggestive of IKD. Additionally, they were suitable for treatment with EJT. After EJT treatment, the physical findings of inflammation disappeared. C‐reactive protein decreased to the normal range. Repeat echocardiography showed no coronary arterial lesions.ConclusionEJT (kampo medicine) has a potential adjunctive role in the acute‐phase management of IKD mimic. Further study on the adjunct efficacy of EJT is needed in patients with IKD and BCG site reactivation.
Immigrants’ Feelings of Attachment to Switzerland: Does the Cantonal Context Matter?
Authors: Bennour Salomon , Manatschal Anita 
Published: February 2019

AbstractThis contribution investigates how cantonal norms of inclusion or exclusion, as expressed by cantonal integration policies and attitudes towards immigrants (xenophobia and right-wing voting), affect immigrants’ national identity in terms of their feelings of attachment to Switzerland. This chapter complements the emerging body of research emphasizing the relevance of studies “beyond and below” national policy frameworks by studying how cantonal integration policy affects immigrants’ national identity, which is a vital – but thus far understudied – factor contributing to social cohesion. The analyses are based on different data sources: the Migration-Mobility Survey, a dataset on cantonal integration policies, and cantonal statistics, e.g., on direct democratic vote results on immigration-related topics or right-wing voting rates. The results of our multilevel analyses show that cantonal reception contexts matter, however not directly but rather as catalysts. In line with assimilation theory, non-citizens’ feelings of attachment to Switzerland increase with time spent in Switzerland. Inclusive cantonal reception contexts and liberal cantonal integration policies in particular amplify this positive effect of years of residence on immigrants’ national identification, except in the most restrictive cantonal reception contexts.
Contention-aware prediction for performance impact of task co-running in multicore computers
Authors: Ren Shenyuan , He Ligang , Li Junyu , Chen Zhiyan , Jiang Peng , Li Chang-Tsun 
Published: February 2019

AbstractIn this paper, we investigate the influential factors that impact on the performance when the tasks are co-running on a multicore computers. Further, we propose the machine learning-based prediction framework to predict the performance of the co-running tasks. In particular, two prediction frameworks are developed for two types of task in our model: repetitive tasks (i.e., the tasks that arrive at the system repetitively) and new tasks (i.e., the task that are submitted to the system the first time).
The difference between which is that we have the historical running information of the repetitive tasks while we do not have the prior knowledge about new tasks. Given the limited information of the new tasks, an online prediction framework is developed to predict the performance of co-running new tasks by sampling the performance events on the fly for a short period and then feeding the sampled results to the prediction framework. We conducted extensive experiments with the SPEC2006 benchmark suite to compare the effectiveness of different machine learning methods considered in this paper. The results show that our prediction model can achieve the accuracy of 99.38% and 87.18% for repetitive tasks and new tasks, respectively.
Perpetration of sexual aggression among adolescents in South Africa
Authors: Kuo Caroline , Mathews Catherine , LoVette Ashleigh , Harrison Abigail , Orchowski Lindsay , Pellowski Jennifer A. , Atujuna Millicent , Stein Dan J. , Brown Larry K. 
Published: February 2019

AbstractIntroductionIn South Africa, one in three men have reported perpetrating rape. Adolescence presents a unique developmental period for primary prevention of violence. However, few studies characterize the epidemiology of sexual violence among adolescents in South Africa.MethodWe evaluated rates of sexual violence behaviors using a baseline survey of N = 200 South African adolescents, age 13–15, recruited for participation in an intervention trial. The intervention focused on preventing onset of depression and sexual risk behavior among adolescents. This sample of adolescents were at elevated risk for depression and recruited using house‐to‐house methods in the community. Sexual perpetration behaviors were assessed using the Sexual Experiences Survey ‐ Short Form Perpetration.ResultsAdolescents most frequently reported the use of coercion, incapacitation, force or threats of force to perpetrate oral sex (15%) followed by sexual touching (14%), anal sex (8%), and vaginal sex at (6%). Perpetration was more common among males compared to females with males perpetrating at a rate of 34.5% vs. 20.5% among females. Attempted perpetration was reported at alarming rates including: vaginal sex (8%), oral sex (8%), and anal sex (5%).ConclusionsPrimary prevention of sexual violence perpetration, including gender‐ and developmentally‐tailored approaches, are urgently needed for adolescents.
Surgical Technique for Complex Cases of Peyronie’s Disease With Implantation of Penile Prosthesis, Multiple Corporeal Incisions, and Grafting With Collagen Fleece
Authors: Fernández-Pascual Esaú , Gonzalez-García Francisco Javier , Rodríguez-Monsalve María , Turo Jorge , Martínez-Ballesteros Claudio , Carballido Joaquín , Martínez-Salamanca Juan Ignacio 
Published: February 2019

Abstract

Introduction
Patients with Peyronie’s disease (PD) and erectile dysfunction (ED) concomitant with shortening or other malformations benefit from prosthesis implantation and penile lengthening procedures.

Aim
To evaluate the safety and efficacy of a multi-incisional technique with penile prosthesis implantation with multiple corporeal incisions and collagen grafting for the surgical management of complex cases of PD with ED and severe penile shortening.

Methods
From February 2015–May 2018, 43 consecutive patients with complex PD were treated using this technique. Implantation of a penile prosthesis (malleable or inflatable [IPP]) together with multiple relaxing tunica albuginea incisions and grafting with a self-adhesive collagen-fibrin fleece (TachoSil, Baxter Healthcare) was performed in all patients by a single surgeon (J.I.M.S.).

Main Outcome Measure
Penile length and curvature correction, operative time, and incidence of postoperative complications were recorded as outcome measures. Functional outcomes were measured with questionnaires (International Index of Erectile Function-5, Erection Hardness Score, modified Erectile Dysfunction Inventory of Treatment Satisfaction questionnaire, PD Questionnaire) before and 3 and 6 months after surgery.

Results
With a median follow-up of 21 months (range 10–31), mean postsurgical penile lengthening was 2.5 (range 1–5) cm, with an improvement in the Bother domain of the PD Questionnaire of 4.4 (range 2–5) points. The average operative time was 86.7 and 71.6 minutes for the IPP and malleable penile prosthesis procedure, respectively. No glans ischemia was recorded; however, 1 IPP infection and 1 delayed distal corporeal erosion were recorded. Hematoma or bruising was observed in 23.2% of patients. The modified Erectile Dysfunction Inventory of Treatment Satisfaction questionnaire was completed by 39 (90.7%) patients. Overall, 89.7% would recommend this surgery. Patient satisfaction with straightness and length was 94.9% and 82.1%, respectively.

Clinical Implications
The described technique helps restoration of penile length and erectile function in patients with complex PD.

Strengths & Limitations
The strength of the study is that it offers a simple, easy-to-apply technique for surgeons to correct shortening and other malformations in patients with ED and complex PD. The study is limited by the small number of patients, the short follow-up period and the performance of the technique by a single high-volume implanter.

Conclusion
The implantation of a penile prosthesis (malleable or inflatable) together with multiple incisions of the plaque/tunica albuginea and grafting with a collagen fleece is a safe and efficient treatment for patients with complex PD in addition to ED and significant shortening.
Trans-Fascial Placement of a High, Sub Muscular Reservoir in Patients Following Radical Cystectomy: Safety, Efficacy, and Predictability of Final Reservoir Location Verified With Abdominal Imaging
Authors: Kava Bruce R. , Lopategui Diana M. , Levine Amanda , Ramasamy Ranjith 
Published: February 2019

Abstract

Introduction
With the increasing utilization of ectopic reservoir placement during multicomponent penile implant surgery, safety concerns have been raised about whether passing the reservoir through the floor of the inguinal canal consistently results in placement of the reservoir within the correct location.

Aim
To evaluate the safety, efficacy, and patient satisfaction associated with direct-vision, trans-fascial sub muscular reservoir placement in consecutive patients who had previously undergone radical cystectomy.

Methods
Perioperative data, complications, and follow up for the 12 cystectomy patients were evaluated using a comprehensive database of consecutive patients undergoing penile prosthesis placement at our center. Efficacy and patient satisfaction were based upon responses to the Erectile Function and Satisfaction Domains of the International Index of Erectile Function (IIEF). Taking advantage of the need for post cystectomy imaging in monitoring for cancer recurrence, we reviewed post- implant imaging with the purpose of ascertaining the final reservoir location.

Main Outcome Measure
Using intraoperative photographs, we describe the technique of trans-fascial sub muscular reservoir placement. Perioperative complications, device efficacy and satisfaction, and the accuracy of reservoir placement are also evaluated.

Results
Average patient age was 65 ± 7 years old and the mean time between cystectomy and implant placement was 41 ± 29 months. With a mean follow up of 26 ± 21 months, complications included: 1 reservoir herniation and 1 high riding pump requiring repositioning. Mean IIEF-EF domain was 29.8 ± 0.5 and mean IIEF-satisfaction domain was 17.7 ± 4.5. Other than the herniated reservoir, imaging confirmed accurate reservoir placement in 8 of 9 cases. In 3 patients a small cephalad portion of the reservoir extends posteriorly into the peritoneal or preperitoneal space, with no clinical consequences.

Clinical Implications
Ectopic reservoir placement using a trans-fascial submuscular approach seems to be a safe method for multicomponent penile implant surgery in patients who have undergone radical cystectomy. Post-implant imaging confirms that the device is consistently placed in the correct sub muscular location.

Strengths & Limitations
This is a novel approach to performing the procedure and a practical manner to ascertain the reservoir position. The limited number of patients prevents generalization of our findings.

Conclusion
Trans-fascial, sub muscular reservoir placement is a safe means of ectopically placing the reservoir of a multicomponent penile implant following radical cystectomy. Post implant IIEF scores indicate high device efficacy and patient satisfaction. Post implant imaging confirms that the reservoir is almost always in the desired location.
Education for Sustainability in Western Australian Secondary Schools: Are We Doing It?
Authors: Prabawa-Sear Kelsie , Dow Vanessa 
Published: February 2019

AbstractThis research was commissioned by the (then) Department of Environment and Conservation (DEC) to provide recommendations on how to best support Western Australian (WA) secondary schools to engage in education for sustainability (EfS). The research aims were to identify barriers and benefits to being involved in EfS, the support systems required for schools to participate in EfS at secondary school level, and the difficulties that secondary schools experience when implementing EfS programs. A variety of research methods were utilised: semi-structured interviews with non-teaching stakeholders; online questionnaires for teachers, school administrators and students; focus groups and semi-structured interviews with teachers and school administrators; and an expert panel workshop to discuss data and recommendations prior to completion of a final report. Data were collected from 29 schools, 45 teachers and school administrators, 186 students, and various EfS external providers and stakeholders across metropolitan and regional WA. This article focuses on three issues identified in the data that we consider important and under-represented in discourses of EfS in Australia: lack of understanding about what EfS means among educators; lack of meaningful student involvement in EfS in secondary schools; and differing quality in EfS programs offered by external providers. We conclude this article by offering ways to improve EfS in WA secondary schools.