bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of Gene Fusions in Driver-Negative Cancer Samples From the National Cancer Institute-Molecular Analysis for Therapy Choice Screening Cohort
Authors: Kaluziak Stefan T. , Codd Elizabeth M. , Purohit Rashi , Melli Beatrice , Kalyan Prinjali , Fordham Jo Anne , Kirkpatrick Grace , McShane Lisa M. , Chang Ting-Chia , Yang Guangxiao , Wang Jinglan , Williams P. Mickey , Karlovich Chris , Sklar Jeffrey , Iafrate A. John 
Published: December 2024

PURPOSE
The National Cancer Institute-Molecular Analysis for Therapy Choice (NCI-MATCH) trial was implemented to identify actionable genetic alterations across cancer types and enroll patients accordingly onto treatment arms, irrespective of tumor histology. Using multiplex polymerase chain reaction (PCR) next-generation sequencing, NCI-MATCH genotyped 5,540 patients, discovering gene fusions in 202/5,540 tumors (3.65%). This result, substantially lower than the fusion detection prevalence of 8.5% across all patients with cancer screened at Massachusetts General Hospital's (MGH) clinical laboratories, supported reanalysis of NCI-MATCH samples identified as mutations-of-interest (MOI)–negative. The assay used by NCI-MATCH requires previous knowledge of both fusion genes, cannot detect novel fusions, and may underestimate fusion-positive patients. Anchored multiplex PCR (AMP) technology permits fusion detection with knowledge of just one gene of the fusion partners.

METHODS
Using AMP-based kits, we reprocessed 663 MOI-negative samples. 200 ng of RNA per sample were shipped from the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network biorepository to MGH (n = 319) and Yale University (n = 344), processed, and sequenced on the NextSeq550. Reported fusions were manually reviewed, and novel fusions orthogonally verified via reverse-transcription PCR and Sanger sequencing.

RESULTS
AMP identified 148 fusions in 142/663 MOI-negative patients (21% [95% CI, 18 to 25]), of which 28 were covered by the Oncomine Comprehensive Assay (OCA) panel but missed, while 120 were not covered by OCA. Among AMP-identified positive patients, 32 had actionable fusions, 24 contained novel fusions, and six had two fusion events. We identified fusions in 12/34 (35% [95% CI, 20 to 54]) cholangiocarcinomas and 43/109 (39% [95% CI, 30 to 49]) sarcomas.

CONCLUSION
Technology and awareness of actionable fusions have improved since the NCI-MATCH trial. With AMP-based technology, we identified 142 patients with fusions not detected during NCI-MATCH screening, many potentially actionable. These striking data underscore the need to optimize the fusion-detection capabilities of genotyping assays used in precision medicine.
Identification of a Suitable Subgroup for Radiation Dose Escalation in Definitive Concurrent Chemoradiation Therapy for Nonmetastatic Esophageal Squamous Cell Carcinoma
Authors: Shen Po-Chien , Chuang Wei-Kai , Dai Yang-Hong , Lo Cheng-Hsiang , Su Yu-Fu , Yang Jen-Fu , Huang Wen-Yen , Lin Chun-Shu , Lu Chia-Feng 
Published: December 2024

PURPOSE
Dose escalation may only be suitable for some patients with esophageal cancer (EC) undergoing concurrent chemoradiotherapy (CCRT). This study aimed to identify specific subgroups of patients for whom dose escalation was most beneficial.

MATERIALS AND METHODS
Between January 2008 and December 2022, 187 patients with EC underwent CCRT; 94 patients received high-dose (HD) radiotherapy (RT; >64.8 Gy), and 93 patients received low-dose (LD) RT. We developed a model on the basis of clinical and radiomic features to compare the predicted survival probabilities of patients with EC receiving HD- and LD-RT. Patients suitable for HD-RT could be identified. We validated our findings of a suitable HD subgroup by evaluating the actual overall survival (OS) across different subgroups in the testing set.

RESULTS

Our model comprised HD and LD submodels, each predicting patient survival under their respective RT doses. The HD and LD submodels achieved concordance indexes of 0.78 and 0.75 in their respective testing sets. The average areas under the receiver operating characteristic curve over years 1-3 were 0.890 and 0.807 in the HD and LD testing sets, respectively. By comparing patients' predicted survival under HD- and LD-RT in the model, we classified the patients in the testing set into the HD-suitable (HDS) subgroup and the HD-unsuitable subgroup. In the subgroup analysis, HD-RT led to a better OS benefit for the identified HDS subgroup compared with LD-RT (
P
= .014). Among the HD-treated patients, the HDS subgroup showed better OS than did patients identified as unsuitable (
P
< .001).

CONCLUSION
We identified a suitable subgroup of patients with EC who might benefit from HD-RT. This model could aid clinicians in prescribing RT doses.
Latinx Cosmopolitanism in the Global South: Víctor Hernández Cruz and the Nostalgia of Egypt
Authors: Quesada Sarah M. 
Published: December 2024

Abstract
This essay addresses the undertheorized three-decade engagement of US Puerto Rican poet Víctor Hernández Cruz with North Africa. In his poems on Egypt, the author argues that Cruz’s particular brand of south–south engagement is excluded from cosmopolitan theory—one that tends to privilege either a Latin American elite or US American mobility. Yet Cruz’s nostalgia for Egyptian antiquity goes as far as to unsettle major conceptions of modernity, especially in his book of poems Beneath the Spanish (2017). By privileging North African epistemologies, Cruz’s poetry challenges the internalization of whiteness for a Latinx population. But part of the issues that arise with this valorization is that Cruz’s poetry draws from a Cold war-era nostalgia of internationalist (or “Nasserist”) rhetoric, and other forms of Egyptian neoliberal nationalisms that complicate Cruz’s particular brand of cosmopolitanism. Despite these complications, Cruz’s transatlantic engagement is distinct in its Global South formulations and expands notions of what it means to be a cosmopolitan in the twenty-first century.
“Une origine oubliée”: Global Modernity and East-West Debates over Classical Heritage
Authors: Johnson Ryan 
Published: December 2024

Abstract
Analogies between the ancient Mediterranean and premodern China and Japan are a well-noted phenomenon in literary studies. Recently, a wealth of scholarship has reignited interest in how people from either side of the Eurasian continent sought to understand one another through comparisons between an imagined shared antiquity. Yet less work has been done comparing Eastern and Western ways of conceiving this analogy with current work in comparative literature. This essay considers late nineteenth- through early twentieth-century East Asian and Western analogies between classical East Asian and ancient Mediterranean cultures. Looking at examples from literature, philosophy, and fine art, it shows that making analogies between classical Chinese and Japanese cultures and ancient Greece and Rome was a shared strategy among prominent European and East Asian figures seeking to renew national traditions by reimagining the origins of both “East” and “West.” However fantastical, these imagined shared histories, seen in the work of Ernest Fenollosa, Watsuji Testurō, W. B. Yeats, and Kuki Shūzō, are an important point of contact between the conceptual foundations of East Asian and Western modernities, and an important element of the study of modernism itself.
Translation and Polylanguaging: Sexuality and Novels from James Baldwin to Mohamed Mbougar Sarr
Authors: Lucey Michael 
Published: December 2024

Abstract
This article examines some conceptual and methodological issues that come up when approaching transcultural relations between sexuality and language in the contemporary world. Most of the examples come from novels. Language about sexuality is often filled with implicitness. To put it differently, it is highly indexical language. This poses problems both for understanding and for translation. How do you talk about sexuality when talking about different times and places in which different languages are spoken and different implicit structures of cultural concepts produce the social forms within which sex/gender and sexuality take place? Added to this is the problem of the coexistence of multiple sexual ideologies and sexual cultures, as well as of multiple languages, in the same social space. “Given that the novel is a fundamentally monolingual form,” Amitav Ghosh has written, “how does it deal with characters whose linguistic identities are complex and unsettled?” In this article, the author examines novelistic situations in which both linguistic and sexual identities are “complex and unsettled.” What are the limits of translation in such situations? What kind of linguistic anthropological work can novels do? Literary examples are drawn from works by James Baldwin, Tahar Ben Jelloun, Abdellah Taïa, and Mohamed Mbougar Sarr.
The Hikayat Abdullah, the Missionary Press, and the Making of Nineteenth-Century “World Literature”
Authors: Werner Winter Jade 
Published: December 2024

Abstract
According to many British Orientalists, Malay was decidedly inferior to Sanskrit or Arabic. This essay examines Abdullah bin Abdul Kadir’s efforts to counter the second-rate status accorded to Malay literature in his autobiography, the Hikayat Abdullah (1849). The text represents an attempt to present Malay writing to European audiences as a coherent national and, by extrapolation, world literature. Retracing Abdullah’s strategic textual work is important not only because it helps explain his status as the “Father of Modern Malay Literature,” but also because it exposes the processes contributing to the construction of nineteenth-century world literature. In its critique of and appeal to Euro-American readers, the Hikayat Abdullah illustrates the degree to which world literature depended on imperial preoccupations with “nationness,” which meant that debates over the “world” status of non-Western texts often played out in colonial microencounters rather than European metropoles. Moreover, Abdullah’s text demonstrates how the secular logics undergirding world literature were significantly produced by missionary institutions, given their involvement in colonial publishing. Contextualizing the Hikayat Abdullah and the broader concept of world literature in this imperial frame, this essay develops a literary microhistory to illumine the criteria to which non-Western texts conformed in order to be regarded as properly “literary.”
What, Why, How and by Whom? Reflections on the Hashtag Movements, the Politics of Knowledge Production and Academic Literacy Pedagogies in South African Higher Education
Authors: Angu Pineteh 
Published: December 2024

Abstract
This article draws primarily on the relevant literature to reflect on two critical moments that changed the South African (SA) higher education landscape: #Rhodesmustfall and #Feesmustfall. It examines how universities have responded to the calls for curriculum decolonisation in the aftermath of the hashtag movements and the implications for reimagining Academic Literacy (AL) pedagogies in SA universities. The article is framed around two arguments. First, although Rhodes fell during the student protests, it did not dismantle the resilient institutional cultures that have sustained racial and epistemic hierarchies. In the context of AL, these epistemic hierarchies often influence module contents, pedagogies and assessment practices. Second, given the socio-economic challenges in SA, curriculum decolonisation should inspire transformative practices in classroom spaces. The article therefore concludes that AL pedagogies should focus on providing students with key cognitive competencies and literacies that can assist them to participate in disrupting Western epistemic domination, increasing their chances of academic success and employability. To achieve these, AL curricula should include discipline/context-specific indigenous and culturally inclusive pedagogies. In addition, lecturers should use a mixture of academic texts that allow students to recognise and appreciate the fact there are different ways of being, knowing and doing.
Enteral Nutrition Tolerability Assessment in Septic Shock Patients in The ICU of RSUP H. Adam Malik Medan
Authors: Ansari Aulia Kamal , Lubis Andriamuri Primaputra , Nadeak Rommy Fransiscus 
Published: December 2024

Background: Enteral nutrition is recommended within 24 to 48 hours after intensive care unit (ICU) admission when resuscitation and hemodynamic stability have been achieved. This study aims to determine the tolerability of enteral nutrition in septic shock patients in the ICU. Objective: To determine the tolerability of enteral nutrition in septic shock patients in the ICU of RSUP H. Adam Malik Medan.Methods: This study is a retrospective observational study, which was conducted in the ICU of the RSUP H. Adam Malik Medan by taking patient data from January to December 2022. The samples were septic shock patients who were admitted to the ICU using mechanical ventilation and vasopressors with a length of treatment of more than 48 hours. Data was collected on the time required for enteral nutrition administration, as well as assessing patient tolerability (presence of vomiting, residuals, and incidence of ileus). Other assessments included length of stay and mortality rate.Result: This study consisted of 47 samples, with 23 male (48.9%) and 24 female (51.1%) samples. Based on the underlying disease, 40.4% of the samples were diagnosed with pneumonia. In the tolerability of enteral nutrition, 83% of the samples were tolerant of early enteral nutrition, but with a high mortality rate of 89.4%. The initiation time of enteral nutrition in patients was 4.94 ± 1.79 hours (p=0.001). The average hospital stay for sepsis patients was 7.30 ± 6.55 days (p=0.001).Conclusion: Most sepsis and septic shock patients in the ICU are tolerant of early enteral nutrition <24 hours, but it does not reduce mortality.
HPLC and GC–MS analyses of phytochemical compounds in Haloxylon salicornicum extract: Antibacterial and antifungal activity assessment of phytopathogens
Authors: Behiry Said , Abdelwahab Eman A. , Al-Askar Abdulaziz A. , Kowalczewski Przemysław , Abdelkhalek Ahmed 
Published: December 2024

Abstract
The present study investigated the phytochemical constituents and antimicrobial effects of aqueous methanolic extract of Haloxylon salicornicum against some phytopathogenic bacterial and fungal strains. The selected bacterial strains were Pectobacterium carotovorum, Pectobacterium atrosepticum, Ralstonia solanacearum, and Streptomyces scabiei, while fungal strains were Fusarium oxysporum, Botrytis cinerea, and Rhizoctonia solani. The extract demonstrated significant efficacy against P. atrosepticum and P. carotovorum at a concentration of 1,000 µg/mL, resulting in inhibition zones measuring 12.3 and 11 mm, respectively. Furthermore, the extract demonstrated considerable effectiveness against fungal strains, achieving an impressive fungal growth suppression rate of 68.8% against R. solani at a concentration of 5,000 µg/mL. The high-performance liquid chromatography analysis identified nine notable phenolic compounds and six common flavonoid compounds in the extract. The identified phenolic compounds in the highest quantities were gallic acid (6427.5 µg/g), vanillin (1145.4 µg/g), chlorogenic acid (498.1 µg/g), and syringic acid (322.5 µg/g). Apigenin (1155.9 µg/g), daidzein (460.9 µg/g), quercetin (382.7 µg/g), and naringenin (160.4 µg/g) exhibited the most significant concentrations of flavonoid compounds. Gas chromatography–mass spectrometry analysis revealed that n-hexadecanoic acid (53.7%), 9-octadecenoic acid (26.9%), 9,12-octadecadienoic acid (Z,Z) (8.67%), palmitic acid, and TMS derivative (4.36%) were the predominant compounds in the extract. Consequently, the H. salicornicum aqueous methanolic extract could be used for the first time as an environmentally safe antimicrobial pesticide agent against plant pathogens to reduce the excessive use of chemical pesticides.
Mediated parent networks as communicative figurations: practical sense and communicative practices among parents in four European countries
Authors: Trültzsch-Wijnen Christine W. , Chimirri Niklas A. , Das Ranjana , Jorge Ana 
Published: December 2024

Abstract
This paper investigates the diversity of mediated parent networks from the perspective of communicative figurations, by focussing on what kinds of networks can be identified (RQ1) and what expectations parents hold towards these networks (RQ2). It draws upon a qualitative, exploratory study conducted in Austria, Denmark, Portugal and the UK, with interviews conducted with parents across 16 families in 2021. Different kinds of parent networks are described in terms of size, perceived publicness, frames of relevance, actors involved, communicative practices, and media ensembles. Our analysis of parents’ expectations shows that disappointment seems to be closely connected to practical sense, social barriers and exclusion.
Modification of dolomitization on reservoir spaces in reef–shoal complex: A case study of Permian Changxing Formation, Sichuan Basin, SW China
Authors: Zhang Qiang , Liu Lizhi , Song Honglu , Jin Chaosu , Qiao Na , Qi Lin 
Published: December 2024

Abstract
The porosity of the reef–shoal complex increases with the increase of dolomite content, and it is worth investigating whether dolomitization leads to the formation of new pores or maintains the original porosity. The reef–shoal complex of the Permian Changxing Formation in the Sichuan Basin is selected to reveal the modification effect of dolomitization on the reef–shoal complex. As important reservoirs of hydrocarbons and carbon dioxide, reef–shoal complexes are composed of grainstone and framestone on both sides of the Kaijiang-Liangping Trough during the Late Permian. The difference in the development degree of sparry calcite cement determines whether the framestone on both sides of the Trough undergoes dolomitization or not. When the Mg2+ supply is insufficient, the dolomitization fluid prioritizes the replacement of the lime mud matrix. When the Mg2+ supply is sufficient, the reef-building organisms and bioclastic grains are completely replaced by dolomite. Statistical results show that when the dolomite content increases from 0 to 40%, there is no significant change in porosity. When dolomite content increases from 40 to 60%, the porosity gradually increases slightly. When dolomite content exceeds 60% and continues to increase, the porosity increases sharply. For reef–shoal complex reservoirs, dolomitization did not lead to the formation of new pores, but effectively preserved primary intergranular pores and freshwater leaching-induced pores. The porosity increases with the increase of dolomite content, partly due to pore preservation and partly due to the more effective anticompaction (and pressure solution) effect of dolomite compared to calcite, reflecting the overall effect of dolomite pore preservation. Although early freshwater leaching played a positive role in the formation of dolomite reservoirs, the preservation effect of dolomite pores contributes more to the current porosity and permeability of reservoirs, resulting in the highest quality reservoirs of reef–shoal complexes often developing at a certain distance below the exposed surface, and the best reservoir is dolomite in the upper part of the reef–shoal complexes, rather than dolomite interval located at the top.
Zein polymer nanocarrier for Ocimum basilicum var. purpurascens extract: Potential biomedical use
Authors: Pedro Amado Hernández-Abril , Hiram Jesús Higuera Valenzuela , Octavio Cota-Arriola , Hugo Enrique Ramírez-Guerra , María Jesús Moreno-Vásquez , Ana Guadalupe Luque-Alcaraz 
Published: December 2024

Abstract
Reactive oxygen species (ROS) are key factors in cellular damage and disease development. Nanoparticles (Nps) have demonstrated significant potential in medicine due to their unique properties, encapsulation of bioactive compounds within Np enhances their stability and efficacy. Ocimum basilicum var. purpurascens (OBP) is a plant characterized by its richness in bioactive antioxidant compounds. This investigation focused on encapsulating an OBP extract (OBPE) within zein nanoparticles (NpZ) and evaluating the preservation of its bioactivity and antioxidant potential. The encapsulation process successfully maintained bioactivity and efficiently extracted bioactive compounds. Comprehensive physicochemical characterization of OBPE-loaded NpZ was performed, including FTIR, DLS, ζ-potential, SEM microscopy, and UV-Vis spectroscopy. Antioxidant activity was evaluated using DPPH, ABTS, and FRAP assays, revealing high antioxidant capacity in OBPE-loaded NpZ. Results revealed the influence of zein concentration on Np characteristics, such as size, charge, and morphology. The extraction method proved effective in preserving bioactive compounds from OBP. Successful OBPE encapsulation within the zein matrix demonstrated NpZ potential as an effective carrier for bioactive compounds. This study highlights the effective extraction and encapsulation of OBPE, emphasizing the importance of NpZ in bioactive antioxidant delivery. Further research on therapeutic efficacy and targeted delivery of OBPE-loaded NpZ in biological models is warranted.
Who Is Interested (or Not) in Church-Administered Lifecycle Rituals?
Authors: Roleder Felix 
Published: December 2024

Abstract
This empirical-quantitative study systematically examines lifecycle ritual choices, including the reluctance to celebrate the rituals offered by the church. Observations of the reasons for ritual choices in the German Protestant context illustrate important shifts in ritual culture. These are also occurring in other contexts around the world marked by religious individualization and cultural singularization. This study finds that religious fit, family constellation and biography, conventionality, and institutional attachment determine affinity to church lifecycle rituals. Thus, the interest in infant baptism, church wedding, and funeral can be conceptualized as a four-dimensional value-rational action. In addition, personal contact with pastors and other church personnel builds trust and creates opportunities for ritual requests. The study thus deepens our understanding of contemporary decision-making processes in a changing ritual culture. The empirical findings offer implications for professionals to adapt their ritual practices in both ritual design and marketing.
Preaching and Generative AI: A Perspective from Early 2024
Authors: Hussey Ian 
Published: December 2024

Abstract

With growing use of generative AI in sermon preparation this article develops the conversation regarding its usage. It begins by discussing some of the ethical issues related to generative AI in preaching. It then suggests that the missiological practice of contextualization also serves as a theological framework for preaching which generates a hermeneutic to locate the ethical and skillful use of AI within the sermon preparation process. It then moves to explore some skills in utilizing generative AI that can be used in sermon preparation in a way that is consistent with this framework.