bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between platelet count and platelet width distribution and serum uric acid concentrations in patients with untreated essential hypertension
Authors: Tayefi Maryam , Hassanian Seyed Mahdi , Maftouh Mona , Moohebati Mohsen , Bahrami Afsane , Parizadeh Seyed MohammadReza , Mahdizadeh Adeleh , Ghazizadeh Hamideh , Bazeli Javad , Heidari‐Bakavoli Alireza , Kianifar Hamidreza , Mohammadzadeh Elham , Rahmani Farzad , Esmaeili Habibollah , Ebrahimi Mahmoud , Azarpazhooh Mahmoud Reza , Nematy Mohsen , Safarian Mohammad , Ferns Gordon A , Avan Amir , Ghayour‐Mobarhan Majid 
Published: September 2018

AbstractHematological parameters have emerged as independent determinants of high serum concentrations of uric acid (UA) and predictive factors in the evaluation of the total cardiovascular risk in patients with essential hypertensive. Here, we have investigated the possible relationships between hematological factors and serum uric acid levels in hypertensive patients recruited as part of Mashhad Stroke and Heart Atherosclerotic Disorders cohort study. Two‐thousand three‐hundred and thirty‐four hypertensive individuals were recruited from this cohort and these were divided into two groups; those with either high or low serum UA concentrations. Demographic, biochemical, and hematological characteristics of population were evaluated in all the subjects. Logistic‐regression analysis was performed to determine the association of hematological parameters with hypertension (HTN). Of the 2334 hypertensive subjects, 290 cases had low UA, and 2044 had high serum UA concentrations. Compared with the low UA group, the patients with high serum UA, had higher values for several hematological parameters, whilst platelet counts (PLT) were lower. Multiple linear regression analysis showed that PLT and serum high sensitivity‐c reactive protein (hs‐CRP) were correlated with serum UA level. Stepwise multiple logistic regression model confirmed that platelet distribution width (PDW) and gender were independent determinant of a high serum UA. PDW and PLT appear to be independently associated with serum UA level in patients with HTN. © 2018 BioFactors, 44(6):532–538, 2018
Effect of beta-blocker therapy on early mortality after emergency colonic cancer surgery
Authors: Ahl R , Matthiessen P , Fang X , Cao Y , Sjolin G , Lindgren R , Ljungqvist O , Mohseni S 
Published: September 2018

Abstract

Background
Emergency colorectal cancer surgery is associated with significant mortality. Induced adrenergic hyperactivity is thought to be an important contributor. Downregulating the effects of circulating catecholamines may reduce the risk of adverse outcomes. This study assessed whether regular preoperative beta-blockade reduced mortality after emergency colonic cancer surgery.

Methods
This cohort study used the prospectively collected Swedish Colorectal Cancer Registry to recruit all adult patients requiring emergency colonic cancer surgery between 2011 and 2016. Patients were subdivided into those receiving regular beta-blocker therapy before surgery and those who were not (control). Demographics and clinical outcomes were compared. Risk factors for 30-day mortality were evaluated using Poisson regression analysis.

Results
A total of 3187 patients were included, of whom 685 (21·5 per cent) used regular beta-blocker therapy before surgery. The overall 30-day mortality rate was significantly reduced in the beta-blocker group compared with controls: 3·1 (95 per cent c.i. 1·9 to 4·7) versus 8·6 (7·6 to 9·8) per cent respectively (P &lt; 0·001). Beta-blocker therapy was the only modifiable protective factor identified in multivariable analysis of 30-day all-cause mortality (incidence rate ratio 0·31, 95 per cent c.i. 0·20 to 0·47; P &lt; 0·001) and was associated with a significant reduction in death of cardiovascular, respiratory, sepsis and multiple organ failure origin.

Conclusion
Preoperative beta-blocker therapy may be associated with a reduction in 30-day mortality following emergency colonic cancer surgery.
Improved lumbar infusion test analysis for normal pressure hydrocephalus diagnosis
Authors: Ryding Erik , Kahlon Babar , Reinstrup Peter 
Published: September 2018

AbstractObjectivesConstant infusion lumbar infusion test (LIT) is an important way to find which patients, of those with signs and symptoms corresponding to normal pressure hydrocephalus (NPH) who will improve from shunt operation. LIT is a stress test on the ability for cerebrospinal fluid re‐absorbtion. The aim of this study is to show how the information from LIT can be improved by quantitative analysis and avoidance of methodological pitfalls.Material and methodsThe potential pitfalls, and the analysis method, are described in detail. The analysis was applied on pre‐operative constant infusion LIT from 31 patients operated for NPH, with known outcome. The pre‐ and post‐operative walking speed was used to grade pathology progression or improvement.ResultsThe maximal, plateau, intra‐spinal pressure at constant infusion LIT is an ambivalent indicator for NPH: while low maximal pressure indicates no cerebrospinal fluid (CSF) absorbtion pathology, too high pressure (≥47 mmHg) may mean no diagnosis, because of stenosis of the Sylvian aqueduct. When subjects with too high intra‐spinal pressure were excluded, the new analysis gave a couple of diagnostic volume parameters, of which one appears to be an optimal LIT parameter for identifying NPH patients with 14% better accuracy than plateau pressure.ConclusionBy avoiding methodological pitfalls, and optimal analysis of the results from lumbar infusion test, the number of NPH patients who do not have a successful outcome after shunt operation may be further decreased.
Kids supporting kids: A 10‐week small group curriculum for grief and loss in schools
Authors: Tillman Kathleen S. , Prazak Michael 
Published: September 2018

AbstractBackgroundExperiencing the death of a loved one can negatively affect a child's emotional, behavioural and academic functioning. However, no in‐school group interventions exist to assist children in processing and grieving the loss of loved ones. To address this, Kids Supporting Kids, a 10‐step group counselling protocol for elementary school students, was developed to help students who have experienced loss of a loved one.AimsThe group curriculum aims to help students develop healthier coping skills to deal with grief‐related distress; decrease internalising and externalising problems; and decrease problematic trauma symptoms. The present study investigates the feasibility of this intervention by capturing feedback from student participants, parents and teachers.MethodologyStudents, teachers and parents were each given pre‐test measures. The group consisted of 10 weekly sessions on the topics of establishing safety, sharing their stories, creating a narrative with positive memories, identifying and expressing emotions, coping skills, social and family support, remembering loved ones and saying goodbye. Students, parents and teachers were also given mid‐group checks and post‐group questionnaires.ResultsQualitative improvements towards these goals were noted by students, parents and teachers. Students reported developing healthier coping skills, which were observed and noted as behavioural and emotional improvements by parents and teachers.ConclusionsThe present feasibility study supports the hypotheses that qualitative improvements would be noted by each group and that the feasibility of this protocol would be supported.
3D printed cardiac fistula: Guiding percutaneous structural intervention
Authors: Aroney Nicholas , Putrino Anthony , Scalia Greg , Walters Darren 
Published: September 2018

AbstractWe present the case of a 21‐year‐old female with a complex right coronary sinus of valsalva to right atrial fistulae. 3D printing of the fistulae and surrounding anatomy was beneficial in assessment of the anatomy and perioperative planning. Successful percutaneous closure was achieved.
Intracardiac echocardiography with ultrasound probe placed in the upper left pulmonary vein to guide left atrial appendage closure: First description
Authors: Patti Giuseppe , Mantione Ludmilla , Goffredo Costanza , Ussia Gian P. 
Published: September 2018

AbstractIntracardiac echocardiography (ICE) has become an effective alternative to trans‐esophageal echocardiography (TEE) as a guidance during interventional procedures for structural heart diseases, allowing to proceed under conscious sedation. To guide percutaneous left atrial appendage (LAA) closure, the ICE probe is usually placed in the right atrium, in the pulmonary artery or in the left atrium (LA); however, the views from the right atrium or the pulmonary artery are often suboptimal, debarring a complete visualization of the LAA and the surrounding structures, whereas the LA location requires trans‐septal puncture, may provoke LA wall mechanical stimulation and is often associated with unstable position of the ICE probe. In our case, after a second trans‐septal puncture, the ICE probe was placed in the upper left pulmonary vein; this was safely performed and provided an optimal imaging of the LAA, comparable to that obtained by TEE, thus warranting an adequate guide during all procedural steps.
References for left main stem dimensions: A cross sectional intravascular ultrasound analysis
Authors: van Zandvoort Laurens J. C. , Tovar Forero Maria N. , Masdjedi Kaneshka , Lemmert Miguel E. , Diletti Roberto , Wilschut Jeroen , de Jaegere Peter , Zijlstra Felix , Van Mieghem Nicolas M. , Daemen Joost 
Published: September 2018

AbstractBackgroundAngiographic assessment of left main coronary artery (LMCA) lesions remains challenging and limited data is available on reference diameters and length of nonobstructive LMCA dimensions. Our aim was to provide insights in the dimensions of nonobstructive LMCA and to find a possible correlation with gender and patient habitus.MethodsThis retrospective single center study was performed in a consecutive cohort of patients who underwent Intravascular Ultrasound (IVUS) guided percutaneous coronary interventions of the left coronary system including complete pullbacks of a non‐obstructive LMCA (n = 254).ResultsMean LMCA length as measured with IVUS was 7.37 ± 4.2 mm and mean lumen area (LA) was 15.63 ± 4.76 mm2 corresponding to a mean lumen diameter (LD) of 4.41 ± 0.67 mm. An IVUS derived mean LD of >4 mm was present in 71.7%, >4.5 mm in 43% and > 5 mm in 19% of patients. LMCA mean LA was significantly smaller in women as compared to men (14.1 ± 4.1 mm2 and 16.2 ± 4.8 mm2, P < 0.01). Multivariable analysis identified weight of the patient as the sole significant predictor for LMCA length while height of the patient and LMCA length were predictors of LMCA mean LA. Correlation coefficients of determination for all independent predictors were low (R2 < 0.1 for all).ConclusionThis study demonstrated that the mean LD of a non‐obstructive LMCA is 4 mm or greater in the majority of patients, with a mean LMCA length of 7.4 mm. Women have smaller luminal dimension than men. No clinically relevant predictors were found for both LMCA length and mean LA.
Use of an AFX aortic cuff in the endovascular treatment of aortocaval fistula secondary to abdominal aortic pseudoaneurysm
Authors: Shatila Wassim , Krajcer Zvonimir 
Published: September 2018

AbstractAortocaval fistula (ACF) is rare and lethal and can be either primary (due to an enlarged abdominal aortic aneurysm) or secondary (iatrogenic or secondary to abdominal surgery) in origin. We describe a case of an ACF secondary to a ruptured abdominal aortic pseudoaneurysm that we successfully treated with a planned endovascular approach using an AFX aortic cuff on both the arterial and venous sides.
Preparation of Novel Aromatic‐Aliphatic Poly(ketone ester)s through Condensation of Biomass‐Derived Monomers
Authors: Chen Qin , Ren Tianhua , Chai Yang , Guo Yuanlong , Ingram Ian D. V. , North Michael , Xie Haibo , Kent Zhao Zongbao 
Published: September 2018

AbstractAbstract: Novel unsaturated and saturated monomers with a hydroxyl group and a carboxylic group via aldol condensation reaction of lignin‐derived aromatic aldehydes with levulinic acid were prepared through organocatalysis and hydrogenation, respectively. The catalytic process was optimized and the structure of the monomers were full characterized. The as‐prepared monomers were ready for the subsequent condensation polymerization to achieve a serial of novel full biobased poly(ester ketone)s. The chemical‐physical properties of the poly(ester ketone)s were evaluated. This provides a green upgrading strategy to prepare sustainable synthetic polymers from building blocks available on a large scale using a catalytic biorefinery approach.
Phosphate‐Based Electrocatalysts for Water Splitting: Recent Progress
Authors: Guo Ronghui , Lai Xiaoxu , Huang Jianwen , Du Xinchuan , Yan Yichao , Sun Yinghui , Zou Guifu , Xiong Jie 
Published: September 2018

AbstractEfficient hydrogen production by water electrolysis is significant for the development of renewable energy. To date, the cost and scarcity of noble‐metal catalysts are limiting their scale‐up applications. To overcome the current challenge, high‐performance novel electrocatalysts are required to speed up the commercialization of electrolysis technology. Notably, the sluggish electrode reactions, namely, the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), especially the latter, have been the main rate‐limiting factor for water splitting. Phosphate, as a new series of OER electrocatalysts, has attracted enormous attentions, owing to its unique lattice structure geometry. The phosphate group not only benefits the adsorption of water molecule but also facilitates the oxyhydrate of metal site and dissociation of water. This Minireview provides a brief summary of the recent progresses of phosphate‐based electrocatalysts, discusses the relationship between crystal structure and catalytic activity, and presents the challenges of phosphate electrocatalysts.
On‐Gold Recombinase Polymerase Primer Elongation for Electrochemical Detection of Bacterial Genome: Mechanism Insights and Influencing Factors
Authors: Sánchez‐Salcedo Raquel , Miranda‐Castro Rebeca , de los Santos‐Álvarez Noemí , Lobo‐Castañón María Jesús 
Published: September 2018

AbstractThe detection of bacterial pathogens may be accomplished through their genome material. With that aim, current methods usually rely on polymerase chain reaction (PCR) amplifications, which are time consuming and require specialist equipment. Here, we optimized an on‐chip isothermal recombinase polymerase amplification (RPA) with chronoamperometric detection, which could be run with simple equipment. A short thiol‐modified oligonucleotide, complementary to a fragment of bipA gene of Salmonella spp., is chemisorbed onto the gold chip surface together with p‐aminothiophenol as a blocking agent. Remarkably, we demonstrate that, in the presence of Salmonella genome, this oligonucleotide, acting as a primer in RPA, is directly elongated on the surface, copying the genome and giving rise to an on‐surface enzyme‐tagged dsDNA. After 30 min of isothermal amplification, the chronoamperometric signal, related to one of the products of the enzyme reaction, increased with the amount of Salmonella genome, which allowed the detection of 105 copies. The results of this study may be of general utility in the design of sensors for detecting other bacteria.
Electrochemical Studies of Anti‐HIV Drug Emtricitabine: Oxidative Determination and Improved Antimicrobial Activity
Authors: Mulik Balaji B. , Dhumal Sambhaji T. , Harale Rajkumar R. , Kharat Kiran R. , Sathe Bhaskar R. 
Published: September 2018

AbstractIn this work, an electroanalytical method adopted for determination of Emtricitabine (EMT) using cyclic and linear sweep voltametry (CV and LSV) on gold (Au dia. 3 mm) disc electrode in 0.5 M KOH as a supporting electrolyte is developed. It is found that the oxidation process is irreversible over a wider pH range and exhibited linear diffusion‐controlled behaviour. EMT exhibits a signal at 0.51 V vs SCE corresponding to oxidation of EMT in 0.5 M KOH on the Au disc electrode. Furthermore, CV and LSV were used to determine electroanalytical parameters like the limit of detection of 0.7069 (LOD), limit of quantification 2.35 (LOQ), sensitivity 0.60 μA mM−1 cm−2, the effect of accumulation, change in pH, sweep rate and effect of concentration (0.001–100 mM) on the stability (less than 5 % potential and current) of the signal. Further stability studies were carried out by monitoring the response on adding some other common biologically active excipients. Additionally, the antimicrobial activity of pristine EMT and its oxidative product shows significant enhancement after oxidative conversion. This work may thus open the door for the design of electrochemical methods for the electrochemical detection followed by determination of various electroanalytical parameters of drug molecules along with their electrochemical conversion to more active forms with comparatively enhanced biological activity. The presented results are reflecting the significant environmental and clinical importance of the presented approach.
Interfacial Ion‐Transport Mechanism of Li7(Al0.1)La3Zr2O12 Solid Electrolyte Modified by using a Spark Plasma Sintering Method
Authors: Bai Lixiong , Xue Wendong , Xue Yawen , Qin Haixia , Li Yan , Li Yong , Sun Jialin 
Published: September 2018

AbstractA novel interfacial in situ modification for Li7(Al0.1)La3Zr2O12 is designed and prepared by using a spark plasma sintering method. The modified interface with most grain boundary area exhibits excellent interfacial electrochemical properties. The X‐ray diffraction (XRD) and scanning electron microscope (SEM) data indicate that the interfacial modified specimen (spark plasma sintering method, 1000 °C, 5 min) with 38.2(6) nm grain diameter and 32,134 cm2/g grain boundary specific surface area has the highest ionic conductivity (8.84×10−4 S/cm−1). The lithium‐ion transmission mechanism in grain‐internal and grain boundaries is revealed by ab initio theory, using Materials Studio software. Furthermore, the first‐principles calculation data indicate that the migration barrier of Li+ at the Li7(Al0.1)La3Zr2O12 solid electrolyte grain boundary is 0.21 eV, which is only 2/3 of that in the grain internal (0.33 eV). As a result, SPS interfacial in situ processing technology can increase the grain boundary area, thereby reducing the ion transport barrier and the interfacial impedance of the material.
100 % Digital Process Industry – Impressions and Results from the Tutzing Symposium 2018
Authors: Kockmann Norbert 
Published: September 2018

AbstractIm April 2018 haben fast 100 Experten und Entscheider in Tutzing über die Auswirkungen digitaler Werkzeuge in der Prozessindustrie diskutiert. Auf Basis des Persona‐Konzepts wurden mit Elementen des Design‐Thinking in den Workshops verschiedene Prototypen entwickelt und in griffige 12 Thesen zusammengefasst. Die enge Datenvernetzung in der gesamten Wertschöpfungskette wie auch der Produkt‐ und Prozessentwicklung wird unterstützt durch den digitalen Zwilling sowie unterschiedliche Methoden der künstlichen Intelligenz.
Experimental methods in chemical engineering: Differential scanning calorimetry—DSC
Authors: Harvey Jean‐Philippe , Saadatkhah Nooshin , Dumont‐Vandewinkel Guillaume , Ackermann Sarah L. G. , Patience Gregory S. 
Published: September 2018

AbstractDifferential calorimetry assesses energy flow between a sample and its environment. The sample may be heated at a known heating rate (either constant or temperature modulated), or held in an isothermal environment or adiabatic environment depending on instrument and experimental design. The subset of differential calorimetry that deals with known heating or cooling rates is termed differential scanning calorimetry (DSC) and is a foundational technique to modern thermodynamics. It reports the heat flow versus temperature or time from which we calculate specific heat capacity at constant pressure, , enthalpy of fusion, and the heat of reaction. Moreover, it identifies how microstuctural properties evolve and thermal arrests—a characteristic of phase transitions. Heat‐flux DSCs measure the temperature difference between a reference and a sample that sit on a thin two‐dimensional plate. Power compensated DSCs heat reference material and the sample in independent furnaces while maintaining each at the same temperature. The Tian‐Calvet DSC is similar to the heat‐flux DSC, but minimizes error induced at high temperature with ring shaped thermopiles that surround the reference and the sample and in most designs incorporate the independent furnaces characteristic of heat flux DSC (three‐dimensional heat flow probe). Convection and radiation energy leaks compromise accuracy above 600 , particularly for pan‐style heat flux and power‐compensated DSC, which are sensitive to heat transfer by conduction only. The Tian‐Calvet DSC maximizes the signal‐to‐noise ratio by enveloping the sample and reference in the thermopile.Web of Science indexed 11 800 articles in 2016 and 2017 that mentioned DSC and assigned 789 to chemical engineering, which ranks it 5th after polymer science, material science, physical chemistry, and multi‐disciplinary chemistry. A bibliometric analysis recognizes four research clusters: polymers and nano‐composites, alloys and kinetics, nano‐particles and drug delivery, and fibres.
State space and movement specification in open population spatial capture–recapture models
Authors: Gardner Beth , Sollmann Rahel , Kumar N. Samba , Jathanna Devcharan , Karanth K. Ullas 
Published: September 2018

AbstractWith continued global changes, such as climate change, biodiversity loss, and habitat fragmentation, the need for assessment of long‐term population dynamics and population monitoring of threatened species is growing. One powerful way to estimate population size and dynamics is through capture–recapture methods. Spatial capture (SCR) models for open populations make efficient use of capture–recapture data, while being robust to design changes. Relatively few studies have implemented open SCR models, and to date, very few have explored potential issues in defining these models. We develop a series of simulation studies to examine the effects of the state‐space definition and between‐primary‐period movement models on demographic parameter estimation. We demonstrate the implications on a 10‐year camera‐trap study of tigers in India. The results of our simulation study show that movement biases survival estimates in open SCR models when little is known about between‐primary‐period movements of animals. The size of the state‐space delineation can also bias the estimates of survival in certain cases.We found that both the state‐space definition and the between‐primary‐period movement specification affected survival estimates in the analysis of the tiger dataset (posterior mean estimates of survival ranged from 0.71 to 0.89). In general, we suggest that open SCR models can provide an efficient and flexible framework for long‐term monitoring of populations; however, in many cases, realistic modeling of between‐primary‐period movements is crucial for unbiased estimates of survival and density.