bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling election dynamics and the impact of disinformation
Authors: Brody Dorje C. 
Published: October 2019

Abstract
Complex dynamical systems driven by the unravelling of information can be modelled effectively by treating the underlying flow of information as the model input. Complicated dynamical behaviour of the system is then derived as an output. Such an information-based approach is in sharp contrast to the conventional mathematical modelling of information-driven systems whereby one attempts to come up with essentially ad hoc models for the outputs. Here, dynamics of electoral competition is modelled by the specification of the flow of information relevant to election. The seemingly random evolution of the election poll statistics are then derived as model outputs, which in turn are used to study election prediction, impact of disinformation, and the optimal strategy for information management in an election campaign.
Conceptual Organization is Revealed by Consumer Activity Patterns
Authors: Hornsby Adam N. , Evans Thomas , Riefer Peter S. , Prior Rosie , Love Bradley C. 
Published: October 2019

Abstract
Computational models using text corpora have proved useful in understanding the nature of language and human concepts. One appeal of this work is that text, such as from newspaper articles, should reflect human behaviour and conceptual organization outside the laboratory. However, texts do not directly reflect human activity, but instead serve a communicative function and are highly curated or edited to suit an audience. Here, we apply methods devised for text to a data source that directly reflects thousands of individuals’ activity patterns. Using product co-occurrence data from nearly 1.3-m supermarket shopping baskets, we trained a topic model to learn 25 high-level concepts (or topics). These topics were found to be comprehensible and coherent by both retail experts and consumers. The topics indicated that human concepts are primarily organized around goals and interactions (e.g. tomatoes go well with vegetables in a salad), rather than their intrinsic features (e.g. defining a tomato by the fact that it has seeds and is fleshy). These results are consistent with the notion that human conceptual knowledge is tailored to support action. Individual differences in the topics sampled predicted basic demographic characteristics. Our findings suggest that human activity patterns can reveal conceptual organization and may give rise to it.
Diagnostic accuracy of a global cognitive screen for Māori and non‐Māori octogenarians
Authors: Zawaly Kristina , Moyes Simon A. , Wood Phil C. , Cheung Gary , Rolleston Anna , Buetow Stephen , Tippett Lynette , Kerse Ngaire 
Published: October 2019

AbstractIntroductionWe assessed the sensitivity and specificity of the Modified Mini–Mental State Examination (3MS) in predicting dementia and cognitive impairment in Māori (indigenous people of New Zealand) and non‐Māori octogenarians.MethodsA subsample of participants from Life and Living in Advanced Age: a Cohort Study in New Zealand were recruited to determine the 3MS diagnostic accuracy compared with the reference standard.ResultsSeventy‐three participants (44% Māori) completed the 3MS and reference standard assessments. The 3MS demonstrated strong diagnostic accuracy to detect dementia with areas under the curve of 0.87 for Māori and 0.9 for non‐Māori. Our cutoffs displayed ethnic variability and are approximately 5 points greater than those commonly applied. Cognitive impairment yielded low accuracy, and discriminatory power was not established.DiscussionCutoffs that are not age or ethnically appropriate may compromise the accuracy of cognitive screens. Consequently, older age and indigeneity increase the risk of mislabeled cognitive status.
Determinants of antenatal HIV testing in the opt-out approach in Nigeria: findings from the Nigerian Demographic and Health Survey
Authors: Udoh Ekerette Emmanuel , Ushie Boniface Ayanbekongshie 
Published: October 2019

AbstractChildren in Nigeria are frequently born with HIV, despite available services to prevent mother-to-child transmission (MTCT). Not offering, or non-acceptance of, HIV testing during antenatal care (ANC) delays anti-retroviral commencement for infected women, thereby increasing the risk of MTCT. This study assessed the determinants of HIV testing during antenatal care in Nigeria using nationally representative data from the 2013 Nigerian Demographic Health Survey. This study included 13,352 women aged 15–49 years who reported having at least one antenatal visit. The outcome variables were HIV testing during ANC and during labour, while socio-demographic and maternal factors, including number of ANC visits, offer of HIV testing during ANC and labour, place of delivery and knowledge and counselling on MTCT, were among the independent variables. Multivariate regression analysis was used to predict HIV testing during ANC and labour. About half (53%) of the women were tested for HIV during antenatal care with 85% of those tested receiving their test results. Only 6% had HIV tests during labour. There was a 33% excess probability of urban women testing during ANC compared with rural women. Never having a previous pregnancy terminated was associated with lower odds of testing during ANC. No counselling on MTCT and no counselling to get tested were associated with a lower probability of testing during ANC. Counselling on the prevention of MTCT is crucial for women’s willingness to be tested, and acceptance of testing. More effort is needed to ensure that providers in Nigeria offer these services to all women, educate women on the dangers of opting out and ensure the earliest commencement of ARV enrolment for those infected.
Pott's puffy tumour: innovative technique in calvarial reconstruction
Authors: Mettias B , Dow G , Srinivasan D , Ramakrishnan Y 
Published: October 2019

AbstractBackgroundPott's puffy tumour is a rare complication of sinusitis. This osteomyelitis can affect the outer and inner tables of the frontal sinus. The treatment of Pott's puffy tumour combines medical and surgical approaches. Surgical approaches have traditionally been open, but endoscopic techniques have been adopted recently in select cases. The bony defect from debridement can be left alone, or closed with autografts or allografts.ObjectiveTo describe a technique for the reconstruction of a large skull vault after the debridement of extensive osteomyelitis of the anterior cranial vault.MethodsModified distraction osteogenesis is used in the cranial vault, to induce new bone formation. This is customarily used to lengthen long bones. The advantages of this technique include avoiding autologous grafts or alloplastic cranioplasty in the infected surgical bed, and allowing primary closure.ResultsEarly post-operative imaging results have been encouraging, with no reported complications.ConclusionModified distraction osteogenesis is a novel technique in the primary reconstruction of calvarial bone.
Measuring the plasma composition in tokamaks with metallic plasma-facing components
Authors: Sertoli M. , Carvalho Pedro Jorge , Giroud C. , Menmuir S. ,   JET Contributors
Published: October 2019

In present and future magnetic confined fusion devices with metallic plasma-facing components (PFCs) such as JET-ILW and ITER, the calculation of the plasma composition must account for multiple impurities of a wide range of mass and charge, resolve their poloidal asymmetries and account for different central peakings for various elements. Single measurements of radiation and effective charge are not enough to characterize this complex system and a self-consistent analysis of data from multiple diagnostics is required. This contribution describes a method to calculate the plasma composition simultaneously accounting for contributions of up to two low-Z impurities, and two mid-/high-Z impurities. The analysis stems from methodologies explained in Sertoli et al. (Rev. Sci. Instrum., vol. 89 (11), 2018, 113501), expanded to include more impurities and to coherently analyse multiple diagnostics within the same framework. The example Ne-seeded JET-ILW hybrid discharge reported here shows that Be, Ne, Ni and W are necessary to simultaneously explain the observed soft X-ray emission, the W concentration measured by passive vacuum ultra-violet spectroscopy, the line-of-sight integrated measurement of the effective charge, the observed poloidal asymmetry of the soft X-ray (SXR) emission, the Ne density measured by charge-exchange-recombination spectroscopy and the line-of-sight integrals of the total radiation as measured by bolometry. This consistent picture of the elemental composition enables the calculation of the radial profiles of the effective charge, the dilution and total radiation. For the cases analysed up to now, these are often very different from the typical assumptions presently used when modelling JET-ILW discharges. This will affect, among others, the calculation of neutron rates, current density profile and heat transport. These considerations are of course valid for all present and future magnetic-controlled fusion devices which exhibit multi-material plasma-facing components, including ITER.
Parents’ gesture adaptations to children with autism spectrum disorder
Authors: YOSHIDA Hanako , CIRINO Paul , MIRE Sarah S. , BURLING Joseph M. , LEE Sunbok 
Published: October 2019

AbstractThe present study focused on parents’ social cue use in relation to young children's attention. Participants were ten parent–child dyads; all children were 36 to 60 months old and were either typically developing (TD) or were diagnosed with autism spectrum disorder (ASD). Children wore a head-mounted camera that recorded the proximate child view while their parent played with them. The study compared the following between the TD and ASD groups: (a) frequency of parent's gesture use; (b) parents’ monitoring of their child's face; and (c) how children looked at parents’ gestures. Results from Bayesian estimation indicated that, compared to the TD group, parents of children with ASD produced more gestures, more closely monitored their children's faces, and provided more scaffolding for their children's visual experiences. Our findings suggest the importance of further investigating parents’ visual and gestural scaffolding as a potential developmental mechanism for children's early learning, including for children with ASD.
An investigation into maternal use of telegraphic input to children with Down syndrome
Authors: LORANG Emily , VENKER Courtney E. , STERLING Audra 
Published: October 2019

AbstractMaternal input influences language development in children with Down syndrome (DS) and typical development (TD). Telegraphic input, or simplified input violating English grammatical rules, is controversial in speech–language pathology, yet no research to date has investigated whether mothers of children with DS use telegraphic input. This study investigated the quality of linguistic input to children with DS compared to age-matched children with TD, and the relationship between maternal input and child language abilities. Mothers of children with DS simplified their input in multiple ways, by using a lower lexical diversity, shorter utterances, and more telegraphic input compared to mothers of children with TD. Telegraphic input was not significantly correlated with other aspects of maternal input or child language abilities. Since children with DS demonstrate specific deficits in grammatical compared to lexical abilities, future work should investigate the long-term influence of maternal telegraphic input on language development in children with DS.
Ice Water Immersion – Practicalities for Monitoring Hyperthermic Patients in the Prehospital Context
Authors: Holbery-Morgan Lachlan , Carew James , Bourke Elyssia , Douglas Ned 
Published: October 2019

AbstractImmersion of patients in a body bag filled with ice and water is recommended as prehospital management of severe hyperthermia. Experienced paramedics have raised a number of concerns about the use of this technique; particularly, whether cardiac monitoring equipment would remain functional once immersed. This test showed that monitoring equipment does remain functional and provides advice about safety considerations. The test should reassure practitioners that such an approach is feasible.
…And if there was also a duty to forget, how would we think about history then?
Authors: Rieff David 
Published: October 2019

AbstractIs remembrance an absolute moral duty or is it better thought of in more ethically constricted pragmatic and empirical terms? This essay argues that both individuals and societies should strive for remembrance where possible, but accept that there are times and places where more forgetting is the only safe choice to make. One may hope that at some point in the future the need to remember will sweep away a prudential decision to forget, but while we are within our moral rights to hope that, in a given case, forgetting itself will outlive its usefulness, conflating our wishes with teleological certainties is an exercise in hubris, not morality. But on no account should memory be thought of as a categorical imperative.
Spitfires Sprouting in the Burmese Spring: The Real-life Quest for Historic Fantasy Aircraft in Contemporary Myanmar
Authors: Ferguson Jane M. 
Published: October 2019

AbstractIn 2013, a group of British aviation archaeologists began excavating in Myanmar in search of some 140 mint-condition crated Royal Air Force (RAF) Spitfire Mk XIV aircraft. According to their story, at the end of the Second World War, Allied forces in Burma were left with these unassembled aircraft. Without the funds to send them home, but unwilling to let the planes fall into enemy hands, they buried the crated planes in Mingaladon, Meiktila and Myitkyina. Like legends of pirate treasure, the story of these buried Spitfires carries with it fantastic aura and intrigue. For aviation fans, the pirate's gold is an iconic aircraft, meaningful in patriotic narratives for its role in the Battle of Britain. This paper will discuss this story as a form of military history folklore which is stoked by the orientalist perception that Burma/Myanmar's decades of military regimes and purported isolation indirectly ‘“preserved” the crated aircraft in time. As this paper will demonstrate, Burmese and others in Southeast Asia have their own legends of buried war materiel and treasure. This point, though largely lost on British aviation enthusiasts in their quest for their Spitfire ‘holy grail’, nevertheless crucially enabled their quest to manifest itself.
Evaluation of sulfonylurea chemistries for strawberry crop safety and Carolina geranium (Geranium carolinianum) efficacy
Authors: Sharpe Shaun M. , Boyd Nathan S. 
Published: October 2019

AbstractPOST weed control atop the bed during strawberry production is limited to hand weeding, clopyralid, and acetyl CoA carboxylase inhibitors. Identification of additional modes of action is desirable to increase available options for producers and alleviate herbicide resistance concerns. The study objective was to screen sulfonylurea herbicides for safety of strawberry coordinated with efficacy against Carolina geranium. Herbicide treatments included metsulfuron-methyl, flazasulfuron, foramsulfuron, thifensulfuron-methyl, trifloxysulfuron-sodium, and rimsulfuron. Strawberry plants were heavily damaged by all herbicides apart from foramsulfuron. Although the strawberry plant was dramatically affected by the evaluated herbicides, demonstrating strong epinasty, there were no differences in resultant biomass at 31 d after treatment (DAT) compared to controls. Carolina geranium was severely injured by metsulfuron-methyl, flazasulfuron, and thifensulfuron-methyl, and moderately injured by foramsulfuron. There were consistent reductions in biomass by 31 DAT by metsulfuron-methyl and flazasulfuron. Overall, metsulfuron-methyl and flazasulfuron are suitable candidates for Carolina geranium control in row-middles. Foramsulfuron is a suitable candidate for additional field-based screening for utility in POST use in strawberry production atop the bed. Consideration toward doses, surfactants, timings, and cultivar tolerance may be necessary to minimize injury as observed in the greenhouse (15% to 20%).
A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma
Authors: Salcher Stefan , Spoden Gilles , Hagenbuchner Judith , Führer Sebastian , Kaserer Teresa , Tollinger Martin , Huber-Cantonati Petra , Gruber Thomas , Schuster Daniela , Gust Ronald , Zwierzina Heinz , Müller Thomas , Kiechl-Kohlendorfer Ursula , Ausserlechner Michael J. , Obexer Petra 
Published: October 2019

AbstractThe transcription factor FOXO3 has been associated in different tumor entities with hallmarks of cancer, including metastasis, tumor angiogenesis, maintenance of tumor-initiating stem cells, and drug resistance. In neuroblastoma (NB), we recently demonstrated that nuclear FOXO3 promotes tumor angiogenesis in vivo and chemoresistance in vitro. Hence, inhibiting the transcriptional activity of FOXO3 is a promising therapeutic strategy. However, as no FOXO3 inhibitor is clinically available to date, we used a medium-throughput fluorescence polarization assay (FPA) screening in a drug-repositioning approach to identify compounds that bind to the FOXO3-DNA-binding-domain (DBD). Carbenoxolone (CBX), a glycyrrhetinic acid derivative, was identified as a potential FOXO3-inhibitory compound that binds to the FOXO3-DBD with a binding affinity of 19 µM. Specific interaction of CBX with the FOXO3-DBD was validated by fluorescence-based electrophoretic mobility shift assay (FAM-EMSA). CBX inhibits the transcriptional activity of FOXO3 target genes, as determined by chromatin immunoprecipitation (ChIP), DEPP-, and BIM promoter reporter assays, and real-time RT-PCR analyses. In high-stage NB cells with functional TP53, FOXO3 triggers the expression of SESN3, which increases chemoprotection and cell survival. Importantly, FOXO3 inhibition by CBX treatment at pharmacologically relevant concentrations efficiently repressed FOXO3-mediated SESN3 expression and clonogenic survival and sensitized high-stage NB cells to chemotherapy in a 2D and 3D culture model. Thus, CBX might be a promising novel candidate for the treatment of therapy-resistant high-stage NB and other “FOXO-resistant” cancers.
All-cause and cause-specific mortality following non-traumatic spinal cord injury: evidence from a population-based cohort study in Switzerland
Authors:   for the SwiSCI study group and the Swiss National Cohort, Buzzell A. , Chamberlain J. D. , Eriks-Hoogland I. , Hug K. , Jordan X. , Schubert M. , Zwahlen M. , Brinkhof M. W. G. 
Published: October 2019

AbstractStudy designObservational cohort study.ObjectiveTo benchmark all-cause and cause-specific mortality following NTSCI to the general population (GP).SettingSpecialized rehabilitation centers in Switzerland.MethodsLongitudinal data from the Swiss Spinal Cord Injury (SwiSCI) Medical Record study were probabilistically linked with cause of death (CoD) information from the Swiss National Cohort. Standardized mortality ratios (SMRs) were estimated for all-cause and cause-specific mortality. Competing risk frameworks were used to estimate the probability of death due to specific CoD.ResultsOne thousand five hundred and one individuals were admitted for first rehabilitation with NTSCI between 1990–2011; CoD information was available for 454 individuals of the 525 individuals that died. Overall, the mortality rate for persons with NTSCI was 1.6 times greater than that of the GP. Deaths due to cardiovascular disease (39.8%), neoplasms (22%), and infection (9.9%) were most often reported. Individuals with an SCI due to a vascular etiology indicated the greatest burden of mortality from infection compared with the GP (SMR 5.4; 95% CI, 3.1 to 9.2).ConclusionsCause-specific SMRs varied according to etiology. This supports the need for targeted clinical care and follow-up. Cardiovascular disease, neoplasms, and infection, emerged as main causes of death following NTSCI and should thus be targets for future research and differential clinical management approaches.
Correction: Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain
Authors: Yu Wei , Gowda Manasa , Sharad Yashsavi , Singh Surindo A. , Sesti Federico 
Published: October 2019

Since the publication of this article the authors have noted that there were two typos that could have caused confusion to the readers:1) References to “integrin alpha chain V” should have been “integrin alpha 5”. These appear in the Abstract and the first paragraph of the Results section.2) In the Results section under the header “Integrins activate Fyn tyrosine kinases” and the legend of Figure 6a, “tyr530” should be replaced with “tyr416”.3) In the the legend of Figure 6b, "pSrc" with should be replaced with "pFyn".
Genomic and phenotypic analyses of six offspring of a genome-edited hornless bull
Authors: Young Amy E. , Mansour Tamer A. , McNabb Bret R. , Owen Joseph R. , Trott Josephine F. , Brown C. Titus , Van Eenennaam Alison L. 
Published: October 2019

AbstractGenome editing followed by reproductive cloning was previously used to produce two hornless dairy bulls. We crossed one genome-edited dairy bull, homozygous for the dominant PC Celtic POLLED allele, with horned cows (pp) and obtained six heterozygous (PCp) polled calves. The calves had no horns and were otherwise healthy and phenotypically unremarkable. We conducted whole-genome sequencing of all animals using an Illumina HiSeq4000 to achieve ~20× coverage. Bioinformatics analyses revealed the bull was a compound heterozygote, carrying one naturally occurring PC Celtic POLLED allele and an allele containing an additional introgression of the homology-directed repair donor plasmid along with the PC Celtic allele. These alleles segregated in the offspring of this bull, and inheritance of either allele produced polled calves. No other unintended genomic alterations were observed. These data can be used to inform conversations in the scientific community, with regulatory authorities and with the public around ‘intentional genomic alterations’ and future regulatory actions regarding genome-edited animals.
Quantitative 3D measurements of tibial plateau fractures
Authors: Assink N. , Kraeima J. , Slump C. H. , ten Duis K. , de Vries J. P. P. M. , Meesters A. M. L. , van Ooijen P. , Witjes M. J. H. , IJpma F. F. A. 
Published: October 2019

AbstractFracture gap and step-off measurements on 2DCT-slices probably underestimate the complex multi-directional features of tibial plateau fractures. Our aim was to develop a quantitative 3D-CT (Q3DCT) fracture analysis of these injuries. CT-based 3D models were created for 10 patients with a tibial plateau fracture. Several 3D measures (gap area, articular surface involvement, 3D displacement) were developed and tested. Gaps and step-offs were measured in 2D and 3D. All measurements were repeated by six observers and the reproducibility was determined by intra-class correlation coefficients. Q3DCT measurements demonstrated a median gap of 5.3 mm, step-off of 5.2 mm, gap area of 235 mm2, articular surface involvement of 33% and 3D displacement of 6.1 mm. The inter-rater reliability was higher in the Q3DCT than in the 2DCT measurements for both the gap (0.96 vs. 0.81) and step-off (0.63 vs. 0.32). Q3DCT measurements showed excellent reliability (ICC of 0.94 for gap area, 1 for articular surface involvement and 0.99 for 3D displacement). Q3DCT fracture analysis of tibial plateau fractures is feasible and shows excellent reliability. 3D measurements could be used together with the current classification systems to quantify the true extent of these complex multi-directional fractures in a standardized way.