bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between paracetamol (acetaminophen) intake between 18 and 32 weeks gestation and neurocognitive outcomes in the child: A longitudinal cohort study
Authors: Golding Jean , Gregory Steven , Clark Rosie , Ellis Genette , Iles‐Caven Yasmin , Northstone Kate 
Published: September 2019

AbstractBackgroundThe majority of epidemiological studies concerning possible adverse effects of paracetamol (acetaminophen) in pregnancy have been focussed on childhood asthma. Initial results of a robust association have been confirmed in several studies. Recently, a few cohort studies have looked at particular neurocognitive outcomes, and several have implicated hyperactivity.ObjectivesIn order to confirm these findings, further information and results are required. Here, we assess whether paracetamol intake between 18 and 32 weeks gestation is associated with childhood behavioural and cognitive outcomes using a large population.MethodsData collected by the Avon Longitudinal Study of Parents and Children (ALSPAC) at 32 weeks gestation and referring to the period from 18 to 32 weeks, identified 43.9% of women having taken paracetamol. We used an exposome analysis first to determine the background factors associated with pregnant women taking the drug, and then allowed for those factors to assess associations with child outcomes (measured using regression analyses).ResultsWe identified 15 variables independently associated with taking paracetamol in this time period, which were used as potential confounders. Of the 135 neurocognitive variables considered, adjusting for the likelihood of false discovery, we identified 56 outcomes for adjusted analyses. Adjustment identified 12 showing independent associations with paracetamol use at P < .05, four of which were at P < .0001 (all related to child behaviours reported by the mother at 42 and 47 months; eg conduct problems: adjusted mean score + 0.22 (95% confidence interval 0.10, 0.33)). There were few associations with behavioural or neurocognitive outcomes after age 7‐8 years, whether reported by the mother or the teacher.ConclusionsIf paracetamol use in mid‐to‐late pregnancy has an adverse effect on child neurocognitive outcome, it appears to mainly relate to the pre‐school period. It is important that these results be tested using other datasets or methodologies before assuming that they are causal.
Kulikovskiyia gen. nov. (Bacillariophyceae) from the lateritic rock pools of the Western Ghats, India and from Hainan Province, China
Authors: Roy Surajit , Liu Yan , Kociolek John Patrick , Lowe Rex L. , Karthick Balasubramanian 
Published: September 2019

ABSTRACTA new triundulate naviculoid diatom genus is described from the Western Ghats of Peninsular India and Hainan Province, China. The new taxon, Kulikovskiyia gen. nov. has robust conical spines along its margin and at the apices and the external valve face has longitudinally‐oriented siliceous slat system extending the length of the valve. The external distal raphe ends bifurcate and terminates on the valve face. There appear to be superficial similarities between this Asian genus and species and Playaensis, a genus comprised of two species found only in the western USA. The systematic position of Kulikovskiyia is discussed, and other than noting its similarities to other biraphid naviculoid diatoms due to symmetry features and the position of the raphe, we are uncertain about its systematic placement at finer levels of classification.
A Case Study Evaluating the Risk of Infection from Middle Eastern Respiratory Syndrome Coronavirus (MERS‐CoV) in a Hospital Setting Through Bioaerosols
Authors: Adhikari Umesh , Chabrelie Alexandre , Weir Mark , Boehnke Kevin , McKenzie Erica , Ikner Luisa , Wang Meng , Wang Qing , Young Kyana , Haas Charles N. , Rose Joan , Mitchell Jade 
Published: September 2019

AbstractMiddle Eastern respiratory syndrome, an emerging viral infection with a global case fatality rate of 35.5%, caused major outbreaks first in 2012 and 2015, though new cases are continuously reported around the world. Transmission is believed to mainly occur in healthcare settings through aerosolized particles. This study uses Quantitative Microbial Risk Assessment to develop a generalizable model that can assist with interpreting reported outbreak data or predict risk of infection with or without the recommended strategies. The exposure scenario includes a single index patient emitting virus‐containing aerosols into the air by coughing, leading to short‐ and long‐range airborne exposures for other patients in the same room, nurses, healthcare workers, and family visitors. Aerosol transport modeling was coupled with Monte Carlo simulation to evaluate the risk of MERS illness for the exposed population. Results from a typical scenario show the daily mean risk of infection to be the highest for the nurses and healthcare workers (8.49 × 10−4 and 7.91 × 10−4, respectively), and the lowest for family visitors and patients staying in the same room (3.12 × 10−4 and 1.29 × 10−4, respectively). Sensitivity analysis indicates that more than 90% of the uncertainty in the risk characterization is due to the viral concentration in saliva. Assessment of risk interventions showed that respiratory masks were found to have a greater effect in reducing the risks for all the groups evaluated (>90% risk reduction), while increasing the air exchange was effective for the other patients in the same room only (up to 58% risk reduction).
Acute Shame Predicts Urges for Suicide but not for Substance Use in a Veteran Population
Authors: Cameron Amy Y. , Shea M. Tracie , Randall Alyson B. 
Published: September 2019

ObjectiveThere is an urgent need to identify ways to reduce rates of suicide among Veterans with a substance use disorder. Since co‐occurring disorders can make diagnosis and treatment complex, it is useful for the mental health field to examine common factors that may underlie both problems. One common factor that underlies both substance use and suicidal behavior is shame. This brief report presents data collected in an experimental study examining shame as an acute risk factor for suicide and substance use in Veterans.MethodThirty‐eight Veterans admitted to an inpatient Veterans Affairs Medical Center unit with suicidal ideation completed measures on depression, hopelessness, addiction, and suicidality. Participants were randomized to either a shame mood induction group or a control group, and completed pre‐ and postexperiment measures on urges for suicide, urges for substance use, and level of shame.ResultsResults indicate that an acute increase in shame resulted in an increase in an urge for suicide, but was not associated with changes in urges for substance use.ConclusionsAcute feelings of shame may be a risk factor for increases in suicidal ideation. Limitations and suggestions for future directions are discussed.
Absence of hyperexcitability of spinal motoneurons in patients with amyotrophic lateral sclerosis
Authors: Marchand‐Pauvert Véronique , Peyre Iseline , Lackmy‐Vallee Alexandra , Querin Giorgia , Bede Peter , Lacomblez Lucette , Debs Rabab , Pradat Pierre‐François 
Published: September 2019

Key points
Amyotrophic lateral sclerosis (ALS) motoneurons become hypoexcitable with disease progression in experimental models, raising questions about the neural hyperexcitability supported by clinical observations.
A variant of the ∆F method, based on motor unit discharge frequency modulations during recruitment and derecruitment, has been developed to investigate the motoneuron capacity to self‐sustained discharge in patients.
The modulation of motor unit firing rate during ramp contraction and vibration‐induced recruitment are modified in ALS, suggesting lower motoneuron capacity to self‐sustained discharge, which is a sign of hypoexcitability.
∆F‐D decreases with functional impairment and its reduction is more pronounced in fast progressors.
In patients with ALS, motoneurons exhibit hypoexcitability, which increases with disease progression.
AbstractExperimental models have primarily revealed spinal motoneuron hypoexcitability in amyotrophic lateral sclerosis (ALS), which is contentious considering the role of glutamate‐induced excitotoxicity in neurodegeneration and clinical features rather supporting hyperexcitability. This phenomenon was evaluated in human patients by investigating changes in motor unit firing during contraction and relaxation. Twenty‐two ALS patients with subtle motor deficits and 28 controls performed tonic contractions of extensor carpi radialis, triceps brachialis, tibialis anterior and quadriceps, aiming to isolate a low‐threshold unit (U1) on the electromyogram (EMG). Subsequently, they performed a stronger contraction or tendon vibration was delivered, to recruit higher threshold unit (U2) for 10 s before they relaxed progressively. EMG and motor unit potential analyses suggest altered neuromuscular function in all muscles, including those with normal strength (Medical Research Council score at 5). During the preconditioning tonic phase, U1 discharge frequency did not differ significantly between groups. During recruitment, the increase in U1 frequency (∆F‐R) was comparable between groups both during contraction and tendon vibration. During derecruitment, the decrease in U1 frequency (∆F‐D) was reduced in ALS regardless of the recruitment mode, particularly for ∆F‐R <8 Hz in the upper limbs, consistent with the muscle weakness profile of the group. ∆F‐D was associated with functional disability and its reduction was more pronounced in patients with more rapid disease progression rate. This in vivo study has demonstrated reduced motoneuron capacity for self‐sustained discharge, and further supports that motoneurons are normo‐ to hypoexcitable in ALS patients, similar to observations in experimental models.
Phase-Opposition Control of the Precessing Vortex Core in Turbulent Swirl Flames for Investigation of Mixing and Flame Stability
Authors: Lückoff Finn , Sieber Moritz , Paschereit Christian Oliver , Oberleithner Kilian 
Published: September 2019

Abstract
The precessing vortex core (PVC) is a helically shaped coherent flow structure that occurs in reacting and nonreacting swirling flows undergoing vortex breakdown. In swirl-stabilized combustors, the PVC affects important phenomena, such as turbulent mixing and thermoacoustic oscillations. In this work, a closed-loop flow control system is developed, which allows for phase-opposition control of the PVC, to achieve appropriate conditions to systematically investigate the influence of the PVC on turbulent flames. The control consists of a zero-net-mass-flux actuator placed in the mixing section of the combustor, where the PVC is most receptive to periodic forcing. The flow control system is characterized from pressure measurements and particle image velocimetry (PIV) and the impact on flame dynamics is extracted from OH*-chemiluminescence measurements. The data reveal that the PVC amplitude is considerably suppressed by the phase-opposition control without changing the overall characteristics of flow and flame, which is crucial to study the exclusive effect of the PVC on combustion processes. Moreover, the control allows the PVC amplitude to be adjusted gradually to investigate the PVC impact on turbulent mixing and flame dynamics. It is revealed that the PVC-induced flow fluctuations mainly affect the large-scale mixing, while the small scale mixing remains unchanged. This is because the suppression of the PVC allows other modes to become more dominant and the overall turbulent kinetic energy (TKE) budget remains unchanged. The destabilization of other modes, such as the axisymmetric mode, may have some implications on thermoacoustic instability.
Modal Analysis of Flange-Mounted Thermowells
Authors: Bartran Dave 
Published: September 2019

Abstract
Avoidance of flow-induced resonance is crucial in managing the failure risk of industrial temperature measurements. To this end, we find that modal analysis of thermowell installations using traditional shell and beam theory, may offer a useful screening tool for at risk installations. This is demonstrated in part by a comparison of predicted resonances of flange-mounted thermowells with those described in reported flow tests.
TURBODYNA: Centrifugal/Centripetal Turbomachinery Dynamic Simulator and Its Application on a Mixed Flow Turbine
Authors: Yang Bijie , Martinez-Botas Ricardo 
Published: September 2019

Abstract
One-dimensional (1D) modeling is crucial for turbomachinery unsteady performance prediction and system response assessment. The purpose of the paper is to describe a newly developed 1D modeling (turbomachinery dynamic simulator (TURBODYNA)) for turbomachinery. Different from classic 1D modeling, in TURBODYNA, rotor has been meshed and its unsteadiness due to flow field timescale is considered. Instead of direct using of performances maps, source terms are added in Euler equation set to simulate the rotor. By comparing 1D modeling with three-dimensional (3D) computational fluid dynamics (CFD) results, it shows that rotor unsteadiness is indispensable for a better prediction. In addition, different variables response to pulse differently. In the rotor, mass flow is close to quasi-steady while entropy is significantly unsteady. TURBODYNA can capture these features correctly and provide an accurate prediction on pressure wave transportation.
Gradient-Augmented Level Set Two-Phase Flow Method With Pretreated Reinitialization for Three-Dimensional Violent Sloshing
Authors: Xin Jianjian , Shi Fulong , Jin Qiu , Ma Lin 
Published: September 2019

AbstractA three-dimensional (3D) gradient-augmented level set (GALS) two-phase flow model with a pretreated reinitialization procedure is developed to simulate violent sloshing in a cuboid tank. Based on a two-dimensional (2D) GALS method, 3D Hermite, and 3D Lagrange polynomial schemes are derived to interpolate the level set function and the velocity field at arbitrary positions over a cell, respectively. A reinitialization procedure is performed on a 3D narrow band to treat the strongly distorted interface and improve computational efficiency. In addition, an identification-correction technique is proposed and incorporated into the reinitialization procedure to treat the tiny droplet which can distort the free surface shape, even lead to computation failure. To validate the accuracy of the present GALS method and the effectiveness of the proposed identification-correction technique, a 3D velocity advection case is first simulated. The present method is validated to have better mass conservation property than the classical level set and original GALS methods. Also, distorted and thin interfaces are well captured on all grid resolutions by the present GALS method. Then, sloshing under coupled surge and sway excitation, sloshing under rotational excitation are simulated. Good agreements are obtained when the present wave and pressure results are compared with the experimental and numerical results. In addition, the highly nonlinear free surface is observed, and the relationship between the excitation frequency and the impulsive pressure is investigated.
Heat Transfer and Flow Structure in a Latticework Duct With Different Sidewalls
Authors: Du Wei , Luo Lei , Wang Songtao , Liu Jian , Sunden Bengt 
Published: September 2019

Abstract
Heat transfer characteristics in a latticework duct with various sidewalls are numerically investigated. The crossing angle is 90 deg and the number of subchannels is eleven on both the pressure side and suction side for each latticework duct. The thickness of the ribs is 8 mm and the distance between adjacent ribs is 24 mm. The investigation is conducted for various Reynolds numbers (11,000 to 55,000) and six different sidewalls. Flow structure, pressure drop, and heat transfer characteristics are analyzed. Results revealed that the sidewall has significant effects on heat transfer and flow structure. The triangle-shaped sidewall provides the highest Nusselt number accompanied by the highest friction factor. The sidewall with a slot shows the lowest friction factor and Nusselt number. An increased slot width decreased the Nusselt number and friction factor simultaneously.
Simulation of the Performance of the Venturi Scrubber for an Advanced Reactor Containment Venting Conditions
Authors: Paridhi Goel , Nayak Arun K. 
Published: September 2019

Abstract
Post Fukushima, nuclear plants are being retrofitted with severe accident mitigation measures. For attaining depressurization of the containment and mitigate the consequences of the release of the radioactivity to the environment during a severe accident condition, filtered containment venting systems (FCVS) are proposed to be installed in existing reactors and being designed for advanced reactors. The design of FCVS is particular to the reactor type. The FVCS configuration considered in this paper comprises of a manifold of venturi scrubber enclosed in a scrubber tank along with metal fiber filter and demister for an advanced Indian reactor. This study focuses on the assessment of the design of the venturi scrubber for the reactor conditions at which venting is carried out through a numerical model. The numerical model is first validated with experiments performed for prototypic conditions. The predicted pressure drop and the iodine absorption efficiency were found to be in good match with the experimental measurements. Subsequently, the model is implemented for predicting the hydrodynamics, i.e., pressure drop, droplet sizes and distribution, and iodine absorption for prototypic conditions. The hydrodynamics, i.e., pressure profile in the venturi scrubber showed a decrease in the converging section and in the throat section. The diverging section showed decrease in recovery of pressure with the decrease in gas flow because of the increased liquid loading to the scrubber. The iodine absorption efficiency showed a value of 92% for high gas velocity which decreased to 68% for the lowest gas flow rate.
Effect of Viscoelasticity on Arterial-Like Pulsatile Flow Dynamics and Energy
Authors: Elliott Winston , Guo Dongjie , Veldtman Gruschen , Tan Wei 
Published: September 2019

Abstract
Time-dependent arterial wall property is an important but difficult topic in vascular mechanics. Hysteresis, which appears during the measurement of arterial pressure–diameter relationship through a cardiac cycle, has been used to indicate time-dependent mechanics of arteries. However, the cause–effect relationship between viscoelastic (VE) properties of the arterial wall and hemodynamics, particularly the viscous contribution to hemodynamics, remains challenging. Herein, we show direct comparisons between elastic (E) (loss/storage &lt; 0.1) and highly viscoelastic (loss/storage &gt; 0.45) conduit structures with arterial-like compliance, in terms of their capability of altering pulsatile flow, wall shear, and energy level. Conduits were made from varying ratio of vinyl- and methyl-terminated poly(dimethylsiloxane) and were fit in a mimetic circulatory system measuring volumetric flow, pressure, and strain. Results indicated that when compared to elastic conduits, viscoelastic conduits attenuated lumen distension waveforms, producing an average of 11% greater cross-sectional area throughout a mimetic cardiac cycle. In response to such changes in lumen diameter strain, pressure and volumetric flow waves in viscoelastic conduits decreased by 3.9% and 6%, respectively, in the peak-to-peak amplitude. Importantly, the pulsatile waveforms for both diameter strain and volumetric flow demonstrated greater temporal alignment in viscoelastic conduits due to pulsation attenuation, resulting in 25% decrease in the oscillation of wall shear stress (WSS). We hope these findings may be used to further examine time-dependent arterial properties in disease prognosis and progression, as well as their use in vascular graft design.
Perinatal hypoxic-ischaemic encephalopathy: a national survey of end-of-life decisions and palliative care
Authors: Arnaez Juan , Herranz-Rubia Nuria , Garcia-Alix Alfredo 
Published: September 2019

ObjectiveTo explore end-of-life (EoL) decision-making and palliative care in hypoxic-ischaemic encephalopathy (HIE) nationwide.MethodsA cross-sectional national study on moderate-to-severe HIE in newborns ≥35 weeks’ gestational age in 2015, including all 57 level III units that offered hypothermia. Forty-one questions were included to explore how the prognosis is established, as well as timing of the decision-making process, and also how ongoing palliative care is offered.ResultsThe main difficulties in EoL decisions lie in the scarce time to make an early, accurate prognosis. Only 20% shared the neurological prognosis with the parents within 72 hours of life, and in only a third of the centres is the nurse present when the prognostic information is given to the family. Almost 50% do not use protocols to order the EoL process. Practically, all centres (91%) reported taking into account the wishes of the parents. However, in 30% the team does not always reach consensus on how the withdrawal process. Specialised psychological support is available in 54% of the hospitals; in more than 50%, interviews are not arranged to examine the grieving process with parents.ConclusionsThere are four areas for improvement in the comprehensive, multidisciplinary approach to the EoL decision in the patient with HIE: (1) the need for EoL and interdisciplinary palliative care protocols, (2) participation of nurses in the process and improvement in the nurse–physician communication, (3) psychological support for parents involved in the EoL decisions and (4) implementation of strategies to give support during the grieving process.
Transcription Factor SOX18 Promotes Clear Cell Renal Cell Carcinoma Progression and Alleviates Cabozantinib-Mediated Inhibitory Effects
Authors: Huaqi Yin , Caipeng Qin , Qiang Wang , Yiqing Du , Xiang Dai , Xu Tang , Xiaowei Zhang , Qing Li , Shijun Liu , Tao Xu 
Published: September 2019

Abstract
The transcription factor SOX18, which was initially discovered as an activator of genetic transcription during embryogenesis, is now implicated in many diseases, including cancer, and is associated with the malignant tumor phenotype, angiogenesis, and lymphangiogenesis. However, the role of SOX18 in clear cell renal cell carcinoma (ccRCC) is not well understood. In the current study, SOX18 expression was evaluated in a 250 case–cohort of primary ccRCC tissues that included 103 cases of matched normal kidney tissues and 21 cases of metastatic tissues. Functional and mechanistic analyses were performed in cells that had SOX18 either overexpressed or silenced to evaluate the effects of SOX18 on cell function, the cellular response to cabozantinib, and SOX18-mediated molecular mechanisms. Our data revealed that upregulation and nuclear translocation of SOX18 promoted ccRCC carcinogenesis and metastasis. Elevated SOX18 expression was associated with advanced pathologic grades and TNM stages, as well as poor patient survival. SOX18 also regulated the cell cycle and the epithelial–mesenchymal transition to promote the malignant phenotype in ccRCC cells. The activation of EGF/EGFR and HGF/c-MET signaling in vitro and in vivo was induced by SOX18. Moreover, SOX18 activation bypassed the inhibitory effects of cabozantinib on cell proliferation, migration, and invasion. In conclusion, our data indicate that SOX18 may be a promising therapeutic target for ccRCC treatment.