bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does size matter? Investigating the optimal planning target volume margin for postoperative stereotactic radiosurgery to resected brain metastases
Authors: Jhaveri Jaymin , Chowdhary Mudit , Zhang Xinyan , Press Robert H. , Switchenko Jeffrey M. , Ferris Matthew J. , Morgan Tiffany M. , Roper Justin , Dhabaan Anees , Elder Eric , Eaton Bree R. , Olson Jeffrey J. , Curran Walter J. , Shu Hui-Kuo G. , Crocker Ian R. , Patel Kirtesh R. 
Published: April 2018

OBJECTIVEThe optimal margin size in postoperative stereotactic radiosurgery (SRS) for brain metastases is unknown. Herein, the authors investigated the effect of SRS planning target volume (PTV) margin on local recurrence and symptomatic radiation necrosis postoperatively.METHODSRecords of patients who received postoperative LINAC-based SRS for brain metastases between 2006 and 2016 were reviewed and stratified based on PTV margin size (1.0 or > 1.0 mm). Patients were treated using frameless and framed SRS techniques, and both single-fraction and hypofractionated dosing were used based on lesion size. Kaplan-Meier and cumulative incidence models were used to estimate survival and intracranial outcomes, respectively. Multivariate analyses were also performed.RESULTSA total of 133 patients with 139 cavities were identified; 36 patients (27.1%) and 35 lesions (25.2%) were in the 1.0-mm group, and 97 patients (72.9%) and 104 lesions (74.8%) were in the > 1.0–mm group. Patient characteristics were balanced, except the 1.0-mm cohort had a better Eastern Cooperative Group Performance Status (grade 0: 36.1% vs 19.6%), higher mean number of brain metastases (1.75 vs 1.31), lower prescription isodose line (80% vs 95%), and lower median single fraction–equivalent dose (15.0 vs 17.5 Gy) (all p < 0.05). The median survival and follow-up for all patients were 15.6 months and 17.7 months, respectively. No significant difference in local recurrence was noted between the cohorts. An increased 1-year rate of symptomatic radionecrosis was seen in the larger margin group (20.9% vs 6.0%, p = 0.028). On multivariate analyses, margin size > 1.0 mm was associated with an increased risk for symptomatic radionecrosis (HR 3.07, 95% CI 1.13–8.34; p = 0.028), while multifraction SRS emerged as a protective factor for symptomatic radionecrosis (HR 0.13, 95% CI 0.02–0.76; p = 0.023).CONCLUSIONSExpanding the PTV margin beyond 1.0 mm is not associated with improved local recurrence but appears to increase the risk of symptomatic radionecrosis after postoperative SRS.
Growth and alignment of the pediatric subaxial cervical spine following rigid instrumentation and fusion: a multicenter study of the Pediatric Craniocervical Society
Authors: Goldstein Hannah E. , Neira Justin A. , Banu Matei , Aldana Philipp R. , Braga Bruno P. , Brockmeyer Douglas L. , DiLuna Michael L. , Fulkerson Daniel H. , Hankinson Todd C. , Jea Andrew H. , Lew Sean M. , Limbrick David D. , Martin Jonathan , Pahys Joshua M. , Rodriguez Luis F. , Rozzelle Curtis J. , Tuite Gerald F. , Wetjen Nicholas M. , Anderson Richard C. E. 
Published: April 2018

OBJECTIVEThe long-term effects of surgical fusion on the growing subaxial cervical spine are largely unknown. Recent cross-sectional studies have demonstrated that there is continued growth of the cervical spine through the teenage years. The purpose of this multicenter study was to determine the effects of rigid instrumentation and fusion on the growing subaxial cervical spine by investigating vertical growth, cervical alignment, cervical curvature, and adjacent-segment instability over time.METHODSA total of 15 centers participated in this multi-institutional retrospective study. Cases involving children less than 16 years of age who underwent rigid instrumentation and fusion of the subaxial cervical spine (C-2 and T-1 inclusive) with at least 1 year of clinical and radiographic follow-up were investigated. Charts were reviewed for clinical data. Postoperative and most recent radiographs, CT, and MR images were used to measure vertical growth and assess alignment and stability.RESULTSEighty-one patients were included in the study, with a mean follow-up of 33 months. Ninety-five percent of patients had complete clinical resolution or significant improvement in symptoms. Postoperative cervical kyphosis was seen in only 4 patients (5%), and none developed a swan-neck deformity, unintended adjacent-level fusion, or instability. Of patients with at least 2 years of follow-up, 62% demonstrated growth across the fusion construct. On average, vertical growth was 79% (4-level constructs), 83% (3-level constructs), or 100% (2-level constructs) of expected growth. When comparing the group with continued vertical growth to the one without growth, there were no statistically significant differences in terms of age, sex, underlying etiology, surgical approach, or number of levels fused.CONCLUSIONSContinued vertical growth of the subaxial spine occurs in nearly two-thirds of children after rigid instrumentation and fusion of the subaxial spine. Failure of continued vertical growth is not associated with the patient’s age, sex, underlying etiology, number of levels fused, or surgical approach. Further studies are needed to understand this dichotomy and determine the long-term biomechanical effects of surgery on the growing pediatric cervical spine.
Characterization of Type Ia Supernova Light Curves Using Principal Component Analysis of Sparse Functional Data
Authors: He Shiyuan , Wang Lifan , Huang Jianhua Z. 
Published: April 2018

Abstract
With growing data from ongoing and future supernova surveys, it is possible to empirically quantify the shapes of SNIa light curves in more detail, and to quantitatively relate the shape parameters with the intrinsic properties of SNIa. Building such relationships is critical in controlling systematic errors associated with supernova cosmology. Based on a collection of well-observed SNIa samples accumulated in the past years, we construct an empirical SNIa light curve model using a statistical method called the functional principal component analysis (FPCA) for sparse and irregularly sampled functional data. Using this method, the entire light curve of an SNIa is represented by a linear combination of principal component functions, and the SNIa is represented by a few numbers called “principal component scores.” These scores are used to establish relations between light curve shapes and physical quantities such as intrinsic color, interstellar dust reddening, spectral line strength, and spectral classes. These relations allow for descriptions of some critical physical quantities based purely on light curve shape parameters. Our study shows that some important spectral feature information is being encoded in the broad band light curves; for instance, we find that the light curve shapes are correlated with the velocity and velocity gradient of the Si II λ6355 line. This is important for supernova surveys (e.g., LSST and WFIRST). Moreover, the FPCA light curve model is used to construct the entire light curve shape, which in turn is used in a functional linear form to adjust intrinsic luminosity when fitting distance models.
L’impact attendu du CICE sur les exportations
Authors: Guillou Sarah , Sampognaro Raul , Treibich Tania 
Published: April 2018

Nous étudions l’impact potentiel du CICE sur le comportement d’exportation des firmes françaises. Notre méthodologie combine des paramètres estimés ex-ante avec l’intensité de traitement observée ex post pour réaliser une évaluation des effets attendus. Selon nos résultats, un effet non négligeable du CICE sur la marge intensive des exportations peut être attendu. Le montant de la créance de 2013 devrait permettre d’observer, à terme, un surplus d’exportations de 1 %, alors que la créance CICE de 2014 permettrait un surplus de 1,3 %. En revanche, le CICE ne devrait pas avoir un impact sensible sur l’entrée de nouveaux exportateurs ou sur la survie d’anciens exportateurs qui seraient devenus plus compétitifs grâce au dispositif. L’entrée et la sortie du marché international sont très faiblement liées au coût salarial. Cependant, si le CICE se traduit à terme par une hausse de l’investissement, d’autres canaux de transmission pourraient influencer la marge extensive du commerce international.
La tour de Jéricho, encore et toujours
Authors: Aurenche Olivier 
Published: April 2018

On propose, à la lumière de découvertes récentes dans le Levant Nord, de faire entrer la tour de Jéricho dans la série des «  bâtiments communautaires » maintenant bien attestés dès le début du Néolithique proche-oriental. Construite en hauteur et non creusée dans le sol, d’accès rendu volontairement difficile, à l’écart du village, la tour pouvait servir de lieu de réunion et d’initiation pour les différentes composantes de la communauté villageoise.
Occupation du sol et conquête territoriale durant le Néolithique dans les Marges arides de Syrie du Nord
Authors: Geyer Bernard , Coqueugniot Éric 
Published: April 2018

Les marges arides de la Syrie du Nord, région de steppe aride située au sud-est d’Alep, se sont révélées très riches en sites archéologiques. La répartition de ces derniers est principalement dictée par une contrainte majeure, l’aridité climatique, de plus en plus marquée d’ouest en est. Mais d’autres éléments interviennent dans cette répartition. Le relief local, la qualité des sols et la ressource en eau, très variables selon les lieux, génèrent une mosaïque de micromilieux aux potentiels différents et aux usages diversifiés selon les époques. Du Kébarien au PPNB récent/final, les espaces parcourus ou occupés ont de ce fait changé, en fonction de stratégies de subsistance. Ces dernières se révèlent avoir été fondées sur des ressources, notamment en eau, très variées, allant de l’exploitation de sources artésiennes pérennes à l’aménagement de « mares » artificielles.
Tell al-Nasriyah (Syrie) et le contact égéen : à propos d’urnes cinéraires
Authors: Faivre Xavier 
Published: April 2018

Entre 2008 et 2010, les fouilles de la nécropole à crémation de Tell al-Nasriyah, à 15 km au nord-est de Hama, sur l’Oronte, ont livré un matériel funéraire abondant constitué d’urnes cinéraires de trois types. L’un de ceux-ci retient particulièrement notre attention car il reflète de profonds bouleversements dans le bassin oriental de la Méditerranée, marquant le passage, en Syrie occidentale, de la culture du Bronze récent à celle du Fer I, au cours du xiie s. av. J.-C. L’objet de cet article est d’envisager, d’une part, la datation de ces urnes en fonction de données chronologiques hétérogènes. On examine, d’autre part, les mécanismes de diffusion et d’intégration de formes et motifs égéens dans la céramique peinte locale. Quelle est la part des circuits d’échanges commerciaux pérennes depuis le Bronze récent, celle des Peuples de la Mer, souvent associés à la diffusion de céramique HR IIIC au Levant ? Les données récentes sur les royaumes néo-hittites de Syrie du Nord apportent peut-être quelques éléments de réponses.
Rapport préliminaire sur les activités de la mission archéologique syro-française de Ras Shamra – Ougarit en 2009 et 2010 (69e et 70e campagnes)
Authors: Haydar Jamal , Al-Bahloul Khozama , Benech Christophe , Bessac Jean-Claude , Bordreuil Etienne , Callot Olivier , Calvet Yves , Carbillet Aurélie , Dardaillon Ella , Geyer Bernard , Goiran Jean-Philippe , Hawley Robert , Herveux Linda , Marriner Nick , Onnis Francesca , Pardee Dennis G. , Rejiba Fayçal , Roche-Hawley Carole , Sauvage Caroline , Matoïan Valérie , al-Maqdissi Michel 
Published: April 2018

Ce rapport présente les résultats préliminaires des travaux de terrain de la mission archéologique syro-française de Ras Shamra – Ougarit qui se sont déroulés en 2009 et 2010. Sur le tell de Ras Shamra, l’étude de la ville d’Ougarit au Bronze récent s’est poursuivie sur plusieurs chantiers (« Rempart » et « Grand-rue » avec la fouille d’un puits en eau, « pont-barrage », étude du quartier à l’est du Palais royal), au travers de l’étude des techniques de construction (taille de la pierre), et par une nouvelle opération portant sur la Maison dite « de Yabninou ». Deux opérations (sondage dans le secteur du temple dit « de Dagan » et prospection géoradar) ont privilégié l’approche diachronique afin de mieux comprendre l’évolution urbanistique de la cité. Les travaux géoarchéologiques de la mission ont porté également sur le site voisin de Ras Ibn Hani afin de reconnaître l’évolution géomorphologique du tombolo au cours de l’Holocène. Au cours de ces deux campagnes, de nombreuses études portant sur le matériel archéologique et épigraphique des fouilles anciennes et récentes se sont par ailleurs poursuivies dans les musées de Damas, d’Alep et de Lattaquié.
Étude technique d’une perle en or de Tell Banat (Syrie) et réflexion sur la diffusion des savoirs au IIIe millénaire av. J.-C.
Authors: Prévalet Romain 
Published: April 2018

Grâce à l’expertise technique des artefacts en métaux précieux, le bijou en or est révélé dans la plus grande précision jusqu’au cœur de sa structure. Ce souci de considérer l’objet comme un assemblage d’éléments résultant de mécanismes opératoires volontairement définis, qui s’inscrivent dans un cadre socio-culturel spécifique, offre de nouvelles perspectives d’analyse des savoir-faire artisanaux. En s’appuyant sur une pièce unique caractérisée par une décoration filigranée et granulée, l’étude vise à reconstituer les procédés techniques en usage à Tell Banat, en Syrie, et à aborder les phénomènes de diffusion des savoirs du travail de l’or du Proche-Orient au Nord-Est égéen durant la seconde moitié du IIIe millénaire.
L’aire funéraire de Tell Aswad (PPNB)
Authors: Stordeur Danielle , Khawam Rima , Jammous Bassam , Morero Élise 
Published: April 2018

Le site néolithique de Tell Aswad, situé à 30 km à l’est-sud-est de Damas, a été découvert et sondé par H. de Contenson en 1972 et 1973. Le site a été fouillé par une équipe franco-syrienne de 2001 à 2006. Les trois phases du PPNB (Horizon PPNB ancien, PPNB moyen, PPNB récent) ont été mises en lumière dans quatorze niveaux archéologiques. Cet article présente une aire funéraire qui se rattache sans doute au début du PPNB récent. Deux groupes de sépultures, représentant deux états successifs, réunissent plus de cinquante individus inhumés selon diverses pratiques (sépultures individuelles, plurielles, primaires, secondaires, combinées). L’état initial de cette aire a été fondé par le dépôt de quatre crânes surmodelés.
Alcohol Brand Use of Youth-Appealing Advertising and Consumption by Youth and Adults
Authors: Padon Alisa A. , Rimal Rajiv N. , Siegel Michael , DeJong William , Naimi Timothy S. , JernFigan David H. 
Published: April 2018

Background Youth exposure to alcohol marketing has been shown to be an important contributor to the problem of underage drinking in the U.S. More work is needed on identifying and minimizing content with particular appeal to youth. Design and Methods We tested the association between the youth-appeal of marketing content of televised alcohol advertisements and the brand-specific alcohol consumption of both underage youth and adults. We used existing data from three sources: a brand-specific alcohol consumption survey among underage youth ( N=1032), a brand-specific alcohol consumption survey among adults ( N ∼13,000), and an analysis of content appealing to youth (CAY) in a sample of televised alcohol advertisements ( n=96) aired during the youth survey. The association between CAY scores for the 96 alcohol ads and youth (age 13-20) versus adult (age 21+) consumption of those ads’ brands was tested through bivariate and multivariate models. Results Brand CAY scores were (a) positively associated with brand-specific youth consumption after controlling for adult brand consumption; (b) positively associated with a ratio of youth-toadult brand-specific consumption; and (c) not associated with adult brand consumption. Conclusions Alcohol brands with youth-appealing advertising are consumed more often by youth than adults, indicating that these ads may be more persuasive to relatively younger audiences, and that youth are not simply mirroring adult consumption patterns in their choice of brands. Future research should consider the content of alcohol advertising when testing marketing effects on youth drinking, and surveillance efforts might focus on brands popular among youth.
Monoidal Categories, 2-Traces, and Cyclic Cohomology
Authors: Hassanzadeh Mohammad , Khalkhali Masoud , Shapiro Ilya 
Published: April 2018

AbstractIn this paper we show that to a unital associative algebra object (resp. co-unital co-associative co-algebra object) of any abelian monoidal category ($\mathscr{C},\otimes$) endowed with a symmetric 2-trace,i.e., an$F\in \text{Fun}(\mathscr{C},\text{Vec})$satisfying some natural trace-like conditions, one can attach a cyclic (resp. cocyclic) module, and therefore speak of the (co)cyclic homology of the (co)algebra “with coefficients in$F$”. Furthermore, we observe that if$\mathscr{M}$is a$\mathscr{C}$-bimodule category and$(F,M)$is a stable central pair,i.e.,$F\in \text{Fun}(\mathscr{M},\text{Vec})$and$M\in \mathscr{M}$satisfy certain conditions, then$\mathscr{C}$acquires a symmetric 2-trace. The dual notions of symmetric 2-contratraces and stable central contrapairs are derived as well. As an application we can recover all Hopf cyclic type (co)homology theories.
Studying volatility from composition, dilution, and heating measurements of secondary organic aerosols formed during α-pinene ozonolysis
Authors: Sato Kei , Fujitani Yuji , Inomata Satoshi , Morino Yu , Tanabe Kiyoshi , Ramasamy Sathiyamurthi , Hikida Toshihide , Shimono Akio , Takami Akinori , Fushimi Akihiro , Kondo Yoshinori , Imamura Takashi , Tanimoto Hiroshi , Sugata Seiji 
Published: April 2018

Abstract. Traditional yield curve analysis shows that semi-volatile organic compounds are a major component of secondary organic aerosols (SOAs). We investigated the volatility distribution of SOAs from α-pinene ozonolysis using positive electrospray ionization mass analysis and dilution- and heat-induced evaporation measurements. Laboratory chamber experiments were conducted on α-pinene ozonolysis, in the presence and absence of OH scavengers. Among these, we identified not only semi-volatile products, but also less volatile highly oxygenated molecules (HOMs) and dimers. Ozonolysis products were further exposed to OH radicals to check the effects of photochemical aging. HOMs were also formed during OH-initiated photochemical aging. Most HOMs that formed from ozonolysis and photochemical aging had 10 or fewer carbons. SOA particle evaporation after instantaneous dilution was measured at  < 1 and  ∼ 40 % relative humidity. The volume fraction remaining of SOAs decreased with time and the equilibration timescale was determined to be 24–46 min for SOA evaporation. The experimental results of the equilibration timescale can be explained when the mass accommodation coefficient is assumed to be 0.1, suggesting that the existence of low-volatility materials in SOAs, kinetic inhibition, or some combined effect may affect the equilibration timescale measured in this study.
Water-stress-induced breakdown of carbon–water relations: indicators from diurnal FLUXNET patterns
Authors: Nelson Jacob A. , Carvalhais Nuno , Migliavacca Mirco , Reichstein Markus , Jung Martin 
Published: April 2018

Abstract. Understanding
of terrestrial carbon and water cycles is currently hampered by an
uncertainty in how to capture the large variety of plant responses to
drought. In FLUXNET, the global network of CO2 and H2O flux
observations, many sites do not uniformly report the ancillary variables
needed to study drought response physiology. To this end, we outline two
data-driven indicators based on diurnal energy, water, and carbon flux
patterns derived directly from the eddy covariance data and based on
theorized physiological responses to hydraulic and non-stomatal limitations.
Hydraulic limitations (i.e. intra-plant limitations on water movement) are
proxied using the relative diurnal centroid (CET*), which
measures the degree to which the flux of evapotranspiration (ET) is shifted
toward the morning. Non-stomatal limitations (e.g. inhibitions of biochemical
reactions, RuBisCO activity, and/or mesophyll conductance) are characterized
by the Diurnal Water–Carbon Index (DWCI), which measures the degree
of coupling between ET and gross primary productivity (GPP) within each day.
As a proof of concept we show the response of the metrics at six European
sites during the 2003 heat wave event, showing a varied response of morning
shifts and decoupling. Globally, we found indications of hydraulic
limitations in the form of significantly high frequencies of morning-shifted
days in dry/Mediterranean climates and savanna/evergreen plant functional
types (PFTs), whereas high frequencies of decoupling were dominated by dry
climates and grassland/savanna PFTs indicating a prevalence of non-stomatal
limitations in these ecosystems. Overall, both the diurnal centroid and DWCI
were associated with high net radiation and low latent energy typical of
drought. Using three water use efficiency (WUE) models, we found the mean
differences between expected and observed WUE to be −0.09 to
0.44 µmol mmol−1 and −0.29 to −0.40 µmol mmol−1 for decoupled
and morning-shifted days, respectively, compared to mean differences −1.41
to −1.42 µmol mmol−1 in dry conditions, suggesting that
morning shifts/hydraulic responses are associated with an increase in WUE,
whereas decoupling/non-stomatal limitations are not.
Analysis of a risk prevention document using dependability techniques: a first step towards an effectiveness model
Authors: Ferrer Laetitia , Curt Corinne , Tacnet Jean-Marc 
Published: April 2018

Abstract. Major hazard prevention is a main challenge given that it is specifically
based on information communicated to the public. In France, preventive
information is notably provided by way of local regulatory documents.
Unfortunately, the law requires only few specifications concerning their
content; therefore one can question the impact on the general population
relative to the way the document is concretely created. Ergo, the purpose of
our work is to propose an analytical methodology to evaluate preventive risk
communication document effectiveness. The methodology is based on
dependability approaches and is applied in this paper to the Document d'Information Communal sur les Risques Majeurs (DICRIM;
in English, Municipal Information Document on Major Risks). DICRIM has to be made by mayors and addressed to the public to provide information on
major hazards affecting their municipalities. An analysis of law compliance
of the document is carried out thanks to the identification of regulatory
detection elements. These are applied to a database of 30 DICRIMs. This
analysis leads to a discussion on points such as usefulness of the missing elements.
External and internal function analysis permits the identification
of the form and content requirements and service and technical functions of
the document and its components (here its sections). Their results are used
to carry out an FMEA (failure modes and effects analysis), which allows us to
define the failure and to identify detection elements.
This permits the evaluation of the effectiveness of form and content of each components
of the document. The outputs are validated by experts from the different
fields investigated. Those results are obtained to build, in future works, a
decision support model for the municipality (or specialised consulting firms)
in charge of drawing up documents.