bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complex regional pain syndrome: An international survey of clinical practice
Authors: Grieve Sharon , Llewellyn Alison , Jones Louise , Manns Sarah , Glanville Victoria , McCabe Candida S. 
Published: August 2019

AbstractBackgroundPublished guidelines promote best practice in complex regional pain syndrome (CRPS) treatment and management; however, these recommendations are not always applied in clinical practice. Understanding existing care internationally will help inform future patient and health professional service delivery, education initiatives and content of clinical guidelines.MethodsAn e‐survey was conducted in order to gain an insight into routine CRPS clinical practice. Health professionals and academics, from the field of CRPS, were recruited from an international population. Quantitative and qualitative data were elicited. Data were mapped onto a framework to identify macro‐regional factors.ResultsOf the 260 survey respondents, 96% (n = 241) provided clinical care for people with CRPS, with academics not involved in patient care also responding. Half of respondents expressed difficulty in recognizing the symptoms of CRPS but treatment aims corresponded with published guidelines. However, a lack of resources and fragmented care were reported as barriers to early intervention. Service constraints were most frequently reported by European respondents. Five themes emerged from the qualitative data: the benefit of interdisciplinary working; the importance of symptom management; need for early diagnosis and intervention; establishing a collaborative partnership with patients; the value of education for patients and health professionals.ConclusionsOur data suggest that more work is required to raise awareness of the Budapest CRPS diagnostic criteria so as to promote early diagnosis and intervention. Future work to optimize clinical effectiveness should consider enhancing interdisciplinary service delivery that encourages a collaborative patient/clinician partnership; includes excellent patient education; and addresses modifiable patient‐related factors.Significance

Health professionals expressed some level of difficulty recognizing the signs and symptoms of CRPS despite the majority of health professionals having had clinical experience exceeding 6 years in the field of CRPS.

More work is required to raise awareness amongst clinicians of the Budapest CRPS diagnostic criteria so as to promote early diagnosis and intervention

Health professionals' treatment aims reflected the current clinical guidelines however, a lack of resources and fragmented care were frequently cited as barriers to achieving these.
Whole‐body reversible neuropathic pain associated with right parieto‐temporal operculum single inflammatory lesion in a patient with multiple sclerosis: A case report
Authors: Poncet‐Megemont Louis , Dallel Radhouane , Chassain Carine , Perrey Antoine , Mathais Sophie , Clavelou Pierre , Moisset Xavier 
Published: August 2019

AbstractBackgroundThe posterior insula and the medial parietal operculum (PIMO) are part of the pain network. Pain can be induced by direct stimulation of the PIMO, but the clinical consequence of lesions in this brain area is not well known.Case reportWe report the case of a patient with multiple sclerosis who presented a relapse characterized by isolated widespread neuropathic pain. The MRI displayed a single new inflammatory lesion in the juxta cortical white matter of the opercular region. This lesion was extended to the parietal operculum and was associated with the pain syndrome. The patient was treated with high‐dose intravenous methylprednisolone, and the pain disappeared progressively. Diffusion‐tensor MRI showed that some of the fibres passing through the lesion ended in the PIMO.ConclusionBased on diffusion‐tensor MRI we hypothesize that the partial disconnection from afference to the PIMO can lead to widespread neuropathic pain.SignificanceMost of the data concerning the functional role of the PIMO come from stereoelectroencephalography in presurgical evaluation of epilepsy, or from functional imaging (PET or fMRI). There is, however, very few data on the consequences of the lesion of the PIMO. Here, we report the first case of a transient widespread pain syndrome associated to a single, small and reversible inflammatory lesion of the PIMO. Thus, this case highlights the key role of the PIMO in spatial perception of pain.
Pain inhibitory mechanisms and response to weak analgesics in patients with knee osteoarthritis
Authors: Petersen Kristian Kjær , Simonsen Ole , Olesen Anne Estrup , Mørch Carsten Dahl , Arendt‐Nielsen Lars 
Published: August 2019

AbstractBackgroundConditioned pain modulation (CPM) and offset analgesia are different features of descending pain inhibition. This study investigated CPM, offset analgesia and clinical pain measures in patients with knee osteoarthritis (KOA) before and after treatment with the combination of a non‐steroidal anti‐inflammatory drug (NSAIDs) plus acetaminophen.MethodsForty‐two patients with KOA received Ibuprofen 1.2 g/daily and acetaminophen 3.0 g/daily for three weeks. Before administration, CPM magnitude was assessed as the difference between cuff pain detection (cPDT) with and without a conditioning stimulus (evoked by tourniquet pain). Offset analgesia was assessed as the pain intensities evoked by a constant 46°C for 30‐s stimulus compared to an offset analgesia paradigm of 46°C for 5‐s, 47°C for 5‐s and 46°C for 20‐s. The worst pain within the last 24‐hr and pain during activity were assessed before and after treatment.ResultsClinical pain significantly decreased after treatment (p < 0.001) and less efficient CPM before treatment was associated with weaker analgesic effect (R = 0.354, p = 0.043). No significant modulation of CPM or offset analgesia was found for the treatment.ConclusionThis study found that less efficient CPM is associated with reduced analgesic effect of NSAIDs plus acetaminophen in patients with KOA whereas the treatment did not modulate CPM nor offset analgesia magnitude.SignificanceThis study demonstrated that conditioned pain modulation is correlated with the response to a standard pharmaceutical interventions treating osteoarthritis pain. Furthermore, we demonstrated that a decrease in clinical pain intensity is not associated with a normalization of conditioned pain modulation or offset analgesia, which questions if restoring these descending pain inhibitory mechanisms are pain intensity driven.
Instantaneous squared VIX and VIX derivatives
Authors: Luo Xingguo , Zhang Jin E. , Zhang Wenjun 
Published: August 2019

AbstractIn this paper, we propose a parsimonious and efficient model to price derivatives written on VIXs with different horizons. Our model is built on Luo and Zhang's (2012, J Futures Markets, 32, 1092–1123) concept of the instantaneous squared VIX (ISVIX) that is the sum of instantaneous diffusive and jump variances of the SPX return. Modeling the ISVIX as a mean‐reverting jump‐diffusion process with a stochastic long‐term mean, we obtain analytical formulas for VIX options and futures. Estimation with VIX term structure and calibration with VIX options data show that our model performs well in matching both time series and cross‐sectional VIX derivatives market prices.
Does maturity matter? The case of treasury futures volume
Authors: Chichernea Doina , Huang Kershen , Petkevich Alex 
Published: August 2019

AbstractWe find that Treasury futures volume contains information about future economic and financial market conditions. Short‐ and long‐term volumes are economically different: A relatively higher volume in short‐term (long‐term) Treasury futures is counter‐cyclical (procyclical), preceding worse (better) economic and financial conditions. Further, we construct a single factor from futures volumes of different maturities that forecasts the performances of Treasury securities and the corporate debt and equity markets, as well as macroeconomic conditions. Our results are consistent with the notion that futures volumes from different market segments reflect differences in beliefs and contain different information about future financial and economic activity.
Thunderstorm occurrence at ten sites across Great Britain over 1884–1993
Authors: Valdivieso Maria , Owens Mathew J. , Scott Chris J. , Hawkins Ed , Burt Stephen , Craig Philip 
Published: August 2019

AbstractThe UK Met Office's Daily Weather Reports (DWR) contain extensive logs of UK thunderstorm activity. To date, only a very small fraction of these data have been digitized as part of the MIDAS dataset, and exclusively after 1950. Using the recently‐scanned UK Met Office Monthly Weather Reports (MWR), which are based on a subset of the observations that form the DWR, we here provide digitized data and a summary of thunderdays from 10 long‐running British stations over the period 1884–1993. The data are presented ‘as is’, with no attempt to provide any corrections or calibration. For 4 of the 10 stations, thunderday observations were discontinued at various times between 1949 and 1964, and it is necessary to switch to a neighbouring station in order to continue the series. Approximately half the series exhibit sharp drops in thunderdays at various points between 1960 and 1990, although none are coincident with known station changes. Comparison with nearby MIDAS stations suggests the low thunderdays are the result of changes in observing practice, rather than genuine changes in thunderstorm occurrence. These potential data issues limit interpretation of the long‐term trends. However, it can nevertheless be concluded that none of the stations show the expected increase in thunderdays as a result of the rise in surface temperature over the 20th century. In order to provide more quantitative determination of the long‐term trends in thunderstorm occurrence, we advocate further digitization efforts to recover the data from the numerous stations in the MWRs, and subsequent analysis of the common signals across neighbouring stations.
Paaliup Qarmangit 1 site geoarchaeology: Taphonomy of a Thule‐Inuit semi‐subterranean dwelling in a periglacial context in northeastern Hudson Bay
Authors: Barbel Héloïse , Bhiry Najat , Todisco Dominique , Desrosiers Pierre , Marguerie Dominique 
Published: August 2019

AbstractA multidisciplinary geoarchaeological investigation was performed at Paaliup Qarmangit 1 site (JjGj‐14), located in a valley affected by periglacial processes in Nunavik, Canada. A taphonomic approach was carried out to document site formation processes on the site of a single‐family semi‐subterranean winter Thule‐Inuit house. Off‐site geomorphological and stratigraphical analyses enabled us to reconstruct the sedimentary environment in the valley since the last glaciation. Valley shoreline sediments deposited during the marine regression were reworked by eolian, runoff, and periglacial processes. The site was first used by Dorset people after 143‐327 cal A.D. and then by the Thule‐Inuit between 1317–1413 cal A.D. and 1466–1642 cal A.D. Strategic features of the site, such as the availability of building material, food, and water resources may explain its sucessive use by two different cultures. On‐site, stratigraphical, micromorphological, and macrofossil analyses showed the predominance of niveo‐eolian and nivation processes in landscape and site formations. The archaeological record reveals the action of niveo‐eolian processes throughout the Medieval Climatic Optimum and the Little Ice Age, likely due to local factors, site location, and the bowl‐shape of the semi‐subterranean house. Macrofossil data and radiocarbon dating indicate postdepositional natural and/or anthropogenic reworking of Dorset artefacts.
Clinician perception of a novel cardiovascular lifestyle prescription form in the primary and secondary care setting in Wales, UK
Authors: Cornell Samuel , Gould Ashley , Ellis Gethin R. , Kenkre Joyce , Williams E Mark 
Published: August 2019

AbstractIssues addressedTo establish the views of clinicians on the feasibility and effectiveness of using a novel lifestyle prescription form (LRx) which requires co‐signing by clinician and patient and is uniquely based on the design of the standard drug prescription form, in the primary and secondary health care settings.MethodsThirty‐six participants were issued with a “prescription” pad, of 20 LRx scripts, for 1 month and requested to issue an LRx prescription to patients they deemed suitable during their consultation, recording their reason for use of the LRx. Each clinician was then asked to complete a comprehensive feedback questionnaire.ResultsFeedback of the LRx was overwhelmingly positive. The script was viewed as a more effective way to convey and support cardiovascular lifestyle advice, than usual care. Forty per cent (196 of 480) of the LRx scripts that were provided to primary and secondary care clinicians during the study period were issued. In most consultations, the LRx script was issued to reaffirm dietary advice. Nurses and health care assistants were more likely than doctors to use the LRx in response to a request for lifestyle advice from a patient.ConclusionsThe LRx may be a useful addition to the clinician's communication toolkit to stimulate lifestyle behaviour changes in their patients. The main barrier to use in the study was lack of consultation time.So what?Issuing the LRx is a method of solidifying lifestyle advice that clinicians could utilise, providing them with another tool in their behaviour change arsenal, particularly with familiarity with the tool.
Exploring the heat transfer performance of nanofluid as a coolant for power battery pack
Authors: Xu Xiaoqin , Xiao Tianli , Chen Shumei , Lin Shaoyi 
Published: August 2019

AbstractNanofluids with high thermal conductivity coefficient are introduced to the thermal management system of power battery packs for electric vehicles and hybrid electric vehicles. Two typical cooling structures of cylindrical and square battery packs are described, and their flow models are established. By similarity transformations, the nonlinear system of partial differential equations is reduced and then solved numerically by the shooting method. The heat transfer properties of three types of nanofluids, that is, CuO‐EG, Al2O3‐EG, TiO2‐EG, are analyzed in detail. It is found that CuO‐EG nanofluid is the best coolant for the cylindrical battery pack, whereas Al2O3‐EG nanofluid is the best choice for square battery pack cooling.
Energy consumption in greenhouses and selection of an optimized heating system with minimum energy consumption
Authors: Mostafavi Seyed Alireza , Rezaei Ali 
Published: August 2019

AbstractIn this paper, heat loss is precisely computed by a proposed code considering different climates. Estimating the costs of different central heating system, unit heaters were selected as the most feasible system. Finally, considering the heating capacity and unit heater's dimensions a computational fluid dynamics model was developed to find the optimized configuration of unit heaters in a typical greenhouse. Using this model, the required thermal load for a greenhouse based on the daily temperature of Arak city in 2017 was computed with a smart control system. It was found that savings in energy consumption were approximately 5447 m3 of natural gas each year.
Free convective magnetohydrodynamic flow over an exponentially stretching sheet with radiation
Authors: Mathur Priya , Mishra Satyaranjan 
Published: August 2019

AbstractThe study explores a steady two‐dimensional magnetohydrodynamic boundary layer flow phenomenon of an incompressible viscous fluid with buoyancy‐driven force over an exponentially stretching sheet. In addition to that, the interaction of thermal radiation in conjunction with dissipative effects, that is, viscous and Joule dissipation is also considered, which is justified due to the presence of magnetic field. The boundary layer equations governed by the flow phenomena are transformed into ordinary differential equations by a suitable choice of similarity transformation. Numerical methods, such as fourth‐order Runge‐Kutta scheme in association with the shooting technique is employed to get an approximate solution of these transformed equations. The numerical computations for the wall shear stress and the heat transfer coefficients are obtained, analyzed, and then discussed. Furthermore, the major findings are pick‐in velocity distribution near the plate is marked with an increase in buoyancy parameter and the rate of heat transfer profile is linear in its boundary layer for low Prandtl number.
Parametric study on the heat transfer characteristics in a circular tube with helical tape insert under laminar flow conditions
Authors: Kumar Shiva , Dinesha Pijakala , Narayanan Akshith , Nanda Rahul 
Published: August 2019

AbstractIn the present study, the effect of a helical coiled tape on the heat transfer characteristics in a tubular heat exchanger has been studied. Numerical analysis is carried out in a tubular heat exchanger with a helical coiled tape insert under laminar flow conditions. The heat transfer characteristics, like Nusselt number (Nu) and friction factor (f), have been determined. Numerical modeling is undertaken and validated using analytical results. To study the parametric variation, simulation is carried out for different width ratios (WR) and twist ratios (TRs). It is observed that Nu increases as the WR is increased and the TR is reduced. The thermohydraulic performance index (THPI) is measured and found to be higher for a combination of a higher WR and a higher TR. From the tested values, it is seen that for a combination of WR = 3 and TR = 1.25, the maximum THPI was observed. It is concluded that both the tape width and pitch will significantly influence the thermohydraulic characteristics in a tubular heat exchanger with a helical tape insert inserted.
Delayed nivolumab‐induced hepatotoxicity during pazopanib treatment for metastatic renal cell carcinoma: An autopsy case
Authors: Todo Maki , Kondo Hideyuki , Hayashi Taiki , Masuda Tsukasa , Okabe Takashi , Kaneko Go , Oyama Masafumi , Shirotake Suguru , Nishimoto Koshiro 
Published: August 2019

IntroductionPazopanib, a tyrosine kinase inhibitor, and nivolumab, an immune checkpoint inhibitor, are both considered to cause hepatotoxicity with different pathophysiology. We report a case in which a patient died of severe hepatotoxicity who was presumed to have been caused by the administration of nivolumab followed by pazopanib for metastatic renal cell carcinoma.Case presentationA 74‐year‐old male with metastatic renal cell carcinoma was treated with nivolumab as a third‐line treatment. However, nivolumab was subsequently discontinued, as it caused severe thyroiditis. About 2 months after the final dose of nivolumab was administered, pazopanib was initiated as a fourth‐line treatment. The patient suffered from lethal hepatic failure and died 18 days after the initiation of pazopanib treatment. An autopsy revealed that CD8‐positive lymphocytes had infiltrated the thyroid gland and liver.ConclusionThe patient was considered to have died of severe hepatic failure due to the aggravation of mild nivolumab‐induced immune‐related hepatitis by pazopanib.
Bioactive glasses and glass‐ceramics versus hydroxyapatite: Comparison of angiogenic potential and biological responsiveness
Authors: Bellucci Devis , Braccini Simona , Chiellini Federica , Balasubramanian Preethi , Boccaccini Aldo R. , Cannillo Valeria 
Published: August 2019

AbstractDifferent bioactive glasses (BGs), bioceramics, and their composites were extensively analyzed in terms of biological responsiveness and angiogenic potential. In particular several inorganic materials were considered, namely the widely used 45S5 BG, an experimental BG with low tendency to crystallize, other three experimental BGs doped with strontium and/or magnesium, a commercial hydroxyapatite (HA), and two BG–HA composites (with varying percentages of BG and HA). All these materials were ad hoc prepared and in vitro tested by means of an extensive biological analysis, such as MC3T3‐E1 cell viability and proliferation by direct contact assay, alkaline phosphatase activity, mineralized matrix deposition analysis by alizarin red staining, as well as evaluation of angiogenic potential and vascular endothelial growth factor release using ST2 cells. Thus, this investigation allows gaining a deeper insight into the biological performance of different inorganic material categories, and to critically compare the different possible solutions, as bone/tissue substitutes for enhanced healing and repair, in terms of bioactivity and regenerative potential.
Polydimethylsiloxane materials with supraphysiological elasticity enable differentiation of myogenic cells
Authors: Świerczek‐Lasek Barbara , Keremidarska‐Markova Milena , Hristova‐Panusheva Kamelia , Vladkova Todorka , Ciemerych Maria Anna , Archacka Karolina , Krasteva Natalia 
Published: August 2019

AbstractMyogenic differentiation during muscle regeneration is guided by various physical and biochemical factors. Recently, substratum elasticity has gained attention as a physical signal that influences both cell differentiation and tissue regeneration. In this work, we investigated the influence of substratum elasticity on proliferation and differentiation of myogenic cells, mouse myoblasts of the C2C12 cell line and mouse primary myoblasts derived from satellite cells—muscle stem cells playing key role in muscle regeneration. Materials with different elastic moduli within the MPa scale based on polydimethylsiloxane (PDMS) were used as cell substratum and characterized for surface roughness, wettability, and micromechanical characteristics. We found that surface properties of PDMS substrates are alter nonlinearly with the increase of the material's elastic modulus. Using this system we provide an evidence that materials with elastic modulus higher than that of physiological skeletal muscle tissue do not perturb myogenic differentiation of both types of myoblasts; thus, can be used as biomaterials for muscle tissue engineering. PDMS materials with elasticity within the range of 2.5–4 MPa may transiently limit the proliferation of myoblasts, but not the efficiency of their differentiation. Direct correlation between substratum elasticity and myogenic differentiation efficiency was not observed but the other surface properties of the PDMS materials such as nanoroughness and wettability were also diverse.
Cyclically near‐resolvable 4‐cycle systems of 2Kv
Authors: Matsubara Kazuki , Kageyama Sanpei 
Published: August 2019

AbstractFu and Mishima [J. Combin. Des. 10 (2002), pp. 116–125] have utilized the extended Skolem sequence to prove that there exists a 1‐rotationally resolvable ‐cycle system of if and only if (mod ). In this paper, the existence of a cyclically near‐resolvable ‐cycle system is discussed, and it is shown that there exists a cyclically near‐resolvable ‐cycle system of if and only if (mod ).