bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Insomnia (Symptoms) in T2D and Association With Metabolic Parameters and Glycemic Control: Meta-Analysis
Authors: Koopman Anitra D M , Beulens Joline W , Dijkstra Tine , Pouwer Frans , Bremmer Marijke A , van Straten Annemieke , Rutters Femke 
Published: October 2019

AbstractObjectiveWe aimed to determine the prevalence of insomnia and insomnia symptoms and its association with metabolic parameters and glycemic control in people with type 2 diabetes (T2D) in a systematic review and meta-analysis.Data SourcesA systematic literature search was conducted in PubMed/Embase until March 2018.Study SelectionIncluded studies described prevalence of insomnia or insomnia symptoms and/or its association with metabolic parameters or glycemic control in adults with T2D.Data ExtractionData extraction was performed independently by 2 reviewers, on a standardized, prepiloted form. An adaptation of Quality Assessment Tool for Quantitative Studies was used to assess the methodological quality of the included studies.Data SynthesisWhen possible, results were meta-analyzed using random-effects analysis and rated using Grading of Recommendations Assessment, Development and Evaluation (GRADE).ResultsA total of 11 329 titles/abstracts were screened and 224 were read full text in duplicate, of which 78 studies were included. The pooled prevalence of insomnia (symptoms) in people with T2D was 39% (95% confidence interval, 34–44) with I2 statistic of 100% (P &lt; 0.00001), with a very low GRADE of evidence. Sensitivity analyses identified no clear sources of heterogeneity. Meta-analyses showed that in people with T2D, insomnia (symptoms) were associated with higher hemoglobin A1c levels (mean difference, 0.23% [0.1–0.4]) and higher fasting glucose levels (mean difference, 0.40 mmol/L [0.2–0.7]), with a low GRADE of evidence. The relative low methodological quality and high heterogeneity of the studies included in this meta-analysis complicate the interpretation of our results.ConclusionsThe prevalence of insomnia (symptoms) is 39% (95% confidence interval, 34–44) in the T2D population and may be associated with deleterious glycemic control.
Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles
Authors: O’Dea Louis St L , MacDougall James , Alexander Veronica J , Digenio Andres , Hubbard Brant , Arca Marcello , Moriarty Patrick M , Kastelein John J P , Bruckert Eric , Soran Handrean , Witztum Joseph L , Hegele Robert A , Gaudet Daniel 
Published: October 2019

AbstractContextDifferentiation between familial chylomicronemia syndrome (FCS, type 1 hyperlipoproteinemia), a rare metabolic disorder, and the more common multifactorial severe hypertriglyceridemia (sHTG, type 5 hyperlipoproteinemia) is challenging because of their overlapping symptoms but important in patient management.ObjectiveTo assess whether readily obtainable clinical information beyond triglycerides can effectively diagnose and differentiate patients with FCS from those with sHTG, based on well-curated data from two intervention studies of these conditions.MethodsThe analysis included 154 patients from two phase 3 clinical trials of patients with sHTG, one cohort with genetically confirmed FCS (n = 49) and one with multifactorial sHTG (n = 105). Logistic regression analyses were performed to determine the ability of variables (patient demographics, medical history, and baseline lipids, individually or in sets) to differentiate the patient populations. Receiver operating characteristics were used to determine the variable sets with the highest accuracy (percentage of times actual values matched predicted) and optimal sensitivity and specificity.ResultsThe primary model diagnosed 45 of 49 patients with FCS and 99 of 105 patients with sHTG correctly. Optimal sensitivity for all available parameters (n = 17) was 91.8%, optimal specificity was 94.3%, and accuracy was 93.5%. Fasting low-density lipoprotein cholesterol (LDL-C) provided the highest individual predictability. However, a three-variable set of ultracentrifugally measured LDL-C, body mass index, and pancreatitis history differentiated the diseases with a near similar accuracy of 91.0%, and adding high-density lipoprotein cholesterol and very low-density lipoprotein cholesterol for a five-variable set provided a small incremental increase in accuracy (92.2%).ConclusionsIn the absence of genetic testing, hypertriglyceridemic patients with FCS and sHTG can be differentiated with a high degree of accuracy by analyzing readily obtainable clinical information.
Impact of Second Opinions in Breast Cancer Diagnostics and Treatment: A Retrospective Analysis
Authors: Heeg E. , Civil Y. A. , Hillen M. A. , Smorenburg C. H. , Woerdeman L. A. E. , Groen E. J. , Winter-Warnars H. A. O. , Peeters M. T. F. D. Vrancken 
Published: October 2019

Abstract

Background
Breast cancer care is becoming increasingly complex, and patients with breast cancer are increasingly aware of the different treatment options, resulting in requests for second opinions (SOs). The current study investigates the impact of breast cancer SOs on final diagnosis and treatment in the Netherlands Cancer Institute (NCI) using a newly designed Breast Cancer Second Opinion (BCSO) classification system.

Methods
Patients who visited the NCI for an SO between October 2015 and September 2016 were included. Demographics, diagnostics, and treatment proposals were compared between first and SO. Discrepancy was categorized using our BCSO classification system, categorizing SOs into (1) noncomparable, (2) identical, and (3) minor or (4) major discrepancy.

Results
The majority of SOs (n = 591) were patient initiated (90.7%). A total of 121 patients underwent treatment prior to their SO, leaving 470 patients for assessment of discrepancies according to our BCSO classification system. More than 45% of these SOs resulted in at least one discrepancy, with comparable rates for physician- and patient-initiated SOs (42.5% vs. 45.6%, p = 0.708). Significantly more discrepancies were observed in patients with additional imaging (51.3% vs. 37.2%, p = 0.002) and biopsies (53.7% vs. 40.3%, p = 0.005). Almost 60% of all discrepancies were categorized as major (neoadjuvant systemic treatment instead of primary surgery, breast-conserving surgery instead of mastectomy, and proposing postmastectomy immediate breast reconstruction).

Conclusions
Our findings show substantial differences in diagnostic and treatment options in breast cancer patients visiting the Netherlands Cancer Institute for an SO, thereby emphasizing more consensus for the indications of these treatment modalities.
Lifelong Physical Activity Determines Vascular Function in Late Postmenopausal Women
Authors: GLIEMANN LASSE , RYTTER NICOLAI , TAMARIZ-ELLEMANN ANDREA , EGELUND JON , BRANDT NINA , CARTER HOWARD H. , HELLSTEN YLVA 
Published: October 2019

ABSTRACT

Introduction
The study evaluated the role of lifelong physical activity for leg vascular function in postmenopausal women (61 ± 1 yr).

Method
The study design was cross-sectional with three different groups based on self-reported physical activity level with regard to intensity and volume over the past decade: inactive (n = 14), moderately active (n = 12), and very active (n = 15). Endothelial-dependent and smooth muscle-dependent leg vascular function were assessed by ultrasound Doppler measurements of the femoral artery during infusion of acetylcholine (Ach), the nitric oxide (NO) donor sodium nitroprusside and the prostacyclin analog epoprostenol. Thigh muscle biopsies, arterial and venous plasma samples were obtained for assessment of vasodilator systems.

Results
The very active group was found to have 76% greater responsiveness to Ach compared with the sedentary group accompanied by 200% higher prostacyclin synthesis during Ach infusion. Smooth muscle cell responsiveness to sodium nitroprusside and epoprostenol was not different between groups. The protein amount of endothelial NO synthase and endogenous antioxidant enzymes in muscle tissue was higher in the very active than the inactive group. The moderately active group had a similar endothelial and smooth muscle cell responsiveness as the inactive group. A secondary comparison with a smaller group (n = 5) of habitually active young (24 ± 2 yr) women indicated that smooth muscle cell responsiveness and endothelial responsiveness are affected by age per se.

Conclusions
This study shows that leg vascular function and the potential to form prostacyclin and NO in late postmenopausal women, is influenced by the extent of lifelong physical activity.
Oral l-Tyrosine Supplementation Improves Core Temperature Maintenance in Older Adults
Authors: LANG JAMES A. , KRAJEK ALEX C. , SCHWARTZ KELSEY S. , RAND JOEL E. 
Published: October 2019

ABSTRACTIntroductionDuring cold exposure, an increase in sympathetic nerve activity evokes vasoconstriction (VC) of cutaneous vessels to minimize heat loss. In older adults, this reflex VC response is impaired thereby increasing their susceptibility to excess heat loss and hypothermia. Becausel-tyrosine, the amino acid substrate necessary for catecholamine production, has been shown to augment reflex VC in age skin, we hypothesize that oral ingestion ofl-tyrosine will attenuate the decline in core temperature (Tc) during whole-body cooling in older adults.MethodsIn a randomized, double-blind design, nine young (25 ± 3 yr) and nine older (72 ± 8 yr) participants ingested either 150 mg·kg−1ofl-tyrosine or placebo before commencing 90 min of whole-body cooling to decrease skin temperature to approximately 29.5°C. Esophageal temperature and forearm laser Doppler flux (LDF) were measured continuously throughout the protocol to provide an index ofTcand skin blood flow, respectively. The change in esophageal temperature (ΔTES) was the difference in temperature at the end of cooling subtracted from baseline. Cutaneous vascular conductance (CVC) was calculated as CVC = LDF/mean arterial pressure and expressed as a percent change from baseline (%ΔCVCBASELINE).ResultsOral tyrosine ingestion augmented the cutaneous VC response to cooling in older adults (placebo, 14.4 ± 2.0; tyrosine, 32.7% ± 1.7% ΔCVCBASELINE;P< 0.05). Additionally, tyrosine improvedTcmaintenance throughout cooling in older adults (placebo, −0.29 ± 0.07; tyrosine, −0.07 ± 0.07 ΔTES;P< 0.05). Both the cutaneous VC andTcduring cooling were similar between young and older adults supplemented with tyrosine (P> 0.05).ConclusionsThese results indicate thatl-tyrosine supplementation improvesTcmaintenance in response to acute cold exposure in an older population.
Prevalence of periodontal diseases and its correlation with different risk factors among an adult Egyptian population: a cross-sectional study
Authors: Abbass Marwa M.S. , Rady Dina , Radwan Israa Ahmed , El Moshy Sara , AbuBakr Nermeen , Ramadan Mohamed , Yussif Nermin , Al Jawaldeh Ayoub 
Published: October 2019

Background: Even though extensive studies on the prevalence of periodontal diseases in various populations worldwide have been carried out, data for the Egyptian population is limited. The present study was carried out to evaluate the prevalence and the severity of periodontal disease and its correlation with different risk factors. Methods: Periodontal examination was performed on 343 adults attending the outpatient clinics of the Faculty of Dentistry, Cairo University, as well as three private clinics. Socio-demographic data, brushing frequency, body mass index (BMI) and dietary habits were recorded using a questionnaire. Results: It was found that 58.9% of participants had calculus deposits. The prevalence of periodontitis was 89.8%, where 70.8% of participants had stage I and 15.2% had stage II, while only 4.4% and 2.05% suffered from stage III and stage IV, respectively. Calculus was positively correlated with age, grains, and sugar in drinks and negatively correlated with socioeconomic status, education level, brushing frequency and milk. Calculus was not correlated with gender and BMI. Periodontitis was positively correlated with age, carbohydrates other than bread, grains, crackers, and caffeinated drinks, while negatively correlated with gender, socioeconomic status, brushing frequency. Periodontitis was not correlated with BMI or education level. Conclusion: The present study clarifies that age, brushing frequency, carbohydrates and caffeinated drinks consumption are significant factors influencing the prevalence and the severity of periodontal diseases.
Study protocol: The INTERMAP China Prospective (ICP) study
Authors: Yan Li , Carter Ellison , Fu Yu , Guo Dongshuang , Huang Pinchun , Xie Gaoqiang , Xie Wuxiang , Zhu Yidan , Kelly Frank , Elliott Paul , Zhao Liancheng , Yang Xudong , Ezzati Majid , Wu Yangfeng , Baumgartner Jill , Chan Queenie 
Published: October 2019

Background: Unfavourable blood pressure (BP) level is an established risk factor for cardiovascular diseases (CVD), while the exact underlying reasons for unfavourable BP are poorly understood. The INTERMAP China Prospective (ICP) Study is a prospective cohort to investigate the relationship of environmental and nutritional risk factors with key indicators of vascular function including BP, arterial stiffness, and carotid-intima media thickness. Methods: A total of 839 Chinese participants aged 40-59 years from three diverse regions of China were enrolled in INTERMAP in 1997/98; data collection included repeated BP measurements, 24-hour urine specimens, and 24-hour dietary recalls. In 2015/16, 574 of these 839 persons were re-enrolled along with 208 new participants aged 40-59 years that were randomly selected from the same study villages. Participant’s environmental and dietary exposures and health outcomes were assessed in this open cohort study, including BP, 24-hour dietary recalls, personal exposures to air pollution, grip strength, arterial stiffness, carotid-media thickness and plaques, cognitive function, and sleep patterns. Serum and plasma specimens were collected with 24-hour urine specimens. Discussion: Winter and summer assessments of a comprehensive set of vascular indicators and their environmental and nutritional risk factors were conducted with high precision. We will leverage advances in exposome research to identify biomarkers of exposure to environmental and nutritional risk factors and improve our understanding of the mechanisms and pathways of their hazardous cardiovascular effects. The ICP Study is observational by design, thus subject to several biases including selection bias (e.g., loss to follow-up), information bias (e.g., measurement error), and confounding that we sought to mitigate through our study design and measurements. However, extensive efforts will apply to minimize those limitations (continuous observer training, repeated measurements of BP, standardized methods in data collection and measurements, and on-going quality control).
Lintasan sampah mikro plastik di kawasan konservasi perairan Nasional Laut Sawu, Nusa Tenggara Timur
Authors: Purba Noir P , Pranowo Widodo S , Simanjuntak Sahat M. , Faizal Ibnu , Jasmin Haifa H. , Handyman Dannisa I.W. , Mulyani Putri G 
Published: October 2019

Abstract. At present, marine debris is an important issue in Indonesia. Due to the complex pattern of ocean currents, research on the distribution of marine waste in Indonesia is still very lacking. This study aims to determine the movement of microplastic particles at the Savu Sea National Marine Park. The method used was to simulate the hydrodynamic model and particle trajectory. Data used were wind, tides, bathymetry, coastline, weight of garbage, and garbage fluxes. Analysis was carried out on physical data visualization, hydrodynamic models, and particle trajectory models. The hydrodynamic model simulation shows if the average current velocity ranges from 0,0002 m/s to 0.35 m/s. The particle trajectory showed that microplastic particle movements tend to move to the south, where some of them move west and east of the Savu Sea. Besides being affected by tides, microplastic particle movements in the Savu Sea National Marine Park are also influenced by various currents that pass through the Savu Sea waters, especially by Indonesia Troughflow.Keywords: ocean model, particle pathways, microdebris, Savu Seas, Indonesia Troughflow Abstrak. Saat ini, sampah laut merupakan salah satu isu kemaritiman di Indonesia. Karena pola pergerakan arus yang kompleks, penelitian mengenai distribusi sampah laut di Indonesia masih sangat kurang. Taman Laut Nasional Laut Sawu sebagai wilayah yang dilalui Arlindo juga memiliki karakteristik oseanografi yang kompleks. Penelitian ini bertujuan untuk mengetahui hasil simulasi pergerakan partikel sampah di Taman Nasional Perairan (TNP) Laut Sawu. Metode yang digunakan yaitu simulasi model hidrodinamika dan lintasan partikel. Data yang digunakan yaitu angin, pasang surut, batimetri, garis pantai, berat sampah, dan flux sampah. Analisis dilakukan terhadap visualisasi data fisik, model hidrodinamika, dan model pergerakan partikel. Simulasi model hidrodinamika menunjukkan jika rata-rata kecepatan arus berkisar antara 0,0002 m/s hingga 0,35 m/s. Hasil simulasi menunjukkan jika pergerakan partikel mikroplastik cenderung bergerak ke selatan, dimana sebagian bergerak ke arah barat dan timur Laut Sawu. Selain dipengaruhi pasang surut, pergerakan partikel mikroplastik di Taman Laut Nasional Laut Sawu juga dipengaruhi oleh berbagai arus yang melewati perairan Laut Sawu khususnya Arlindo.Kata kunci: pemodelan, lintasan partikel, sampah mikro, Laut Sawu, Arlindo.
Confrontation du standard Maison Passive à la notion d'architecture soutenable
Authors: Van Moeseke Geoffrey 
Published: October 2019

Le Standard Maison Passive a été défini il y a 20 ans et s'est rapidement répandu en Europe suite au projet Cepheus. L'article pointe le caractère essentiellement performantiel du standard Maison Passive, et pose la question de la cohérence de ce standard avec une définition plus large de l'architecture soutenable, englobant de multiples dimensions environnementales, sociales et culturelles.
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ATENÇÃO FARMACÊUTICA A PACIENTES DO SISTEMA ÚNICO DE SAÚDE COM ACNE GRAVE: UM SERVIÇO DE SAÚDE NO AMBIENTE ACADÊMICO
Authors: Rodrigues Marília de Carvalho , Bezerra Walkiria Brenda de Sousa , Benvindo Trajano Leticia Paula , Barbosa Ferreira Pablo Ricardo , Ferreira de Araújo Éverton José 
Published: October 2019

Acne é uma doença cutânea, genética-hormonal que provoca a formação de comedões, pápulas e pústulas na região da face e do tórax. A presente pesquisa avaliou o impacto da Atenção Farmacêutica a pacientes do Sistema Único de Saúde (SUS) que recebem isotretinoína sistêmica gratuitamente para o tratamento de acne grave em um serviço de saúde desenvolvido em uma farmácia universitária pública inserida no Componente Especializado da Assistência Farmacêutica. Trata-se de um estudo descritivo, retrospectivo e quantitativo baseado na análise das fichas de acompanhamento farmacoterapêutico, intervenções farmacêuticas e exames laboratoriais documentados em registros internos de pacientes assistidos pela Farmácia Escola da Universidade Federal do Piauí no período de novembro de 2015 a julho de 2017. Foram analisados os registros de 23 pacientes nos quais foram constatados 34 tipos de reações adversas ao medicamento, além de 4 intervenções farmacêuticas, predominantemente relacionadas ao risco de interações medicamentosas. A pesquisa ressalta a notoriedade da iniciativa da implantação desse tipo de serviço em locus acadêmico para a formação de novos profissionais da saúde, além dos benefícios do acompanhamento farmacêutico aos pacientes com acne grave.
The Image of the Little Child and its Upbringing as Reflected in Yconomica by Conrad of Megenburg. A Contribution to the History of Education in the Late Middle Ages
Authors: Brzeziński Witold 
Published: October 2019

The paper is concerned with the views of the fourteenth-century German thinker and writer Conrad of Megenburg on the nature of a little child (until the age of seven) and his or her upbringing as reflected in his Yconomica. This work belonged to the oeconomica genre – books of instructions about the prudent management of the household, including recommendations on the proper upbringing of offspring. Conrad perceives the child primarily as lacking an ability to reason. Consequently, in his opinion what the child speaks or does is only a mindless imitation – a kind of aping – of what he or she hears or sees in others. Therefore, recommendations given by Conrad to parents on how they should take care of their children are mostly concerned with their health and proper physical development. To a lesser degree the first years of living is a time for the child to learn some good manners, e.g. while eating and to gain basic religious knowledge. This kind of learning, however, does not require any understanding, it consists in developing appropriate habits in children. Only when they reach the age of seven did their proper education begin. In his view of the little child and his or her upbringing Conrad of Megenburg follows the Aristotelian tradition.
From the history of disabilities (16th-19th century)
Authors: Kulbaka Jacek 
Published: October 2019

The article presents various circumstances (social, legal, philosophical and scientific) connected with the care, upbringing and education of people with disabilities from the early modern era to the beginning of the 20th century. Particular attention was to the history of people with disabilities in the Polish lands. The author tried to recall the activity of leading educational activists, pedagogues and scientists – animators of special education in Poland, Europe and the world. The text also contains information related to the activities of educational and upbringing institutions (institutional, organisational, methodological and other aspects).
Name Giving Process: Linguistic and Extralinguistic Challenges
Authors: Zerkina Natalya , Kisel Olesya , Savinova Yuliya , Zalavina Tatyana , Kozhushkova Natalya , Akhmetzyanova Tatyana 
Published: October 2019

Abstract
This research is the first attempt to investigate the problem of the influence of social factors on the process of the name giving taking into account – its motives. The authors made an attempt to divide and systematize social factors of different character, describe their influence on the name giver. From the linguistic point of view, the authors describe in detail the process of changing the onym semantic structure under the influence of social factors. At the modern stage of the anthroponymics progress, the researchers described only social factors influencing name giving, however, their systematization has not been made. For detailed studying of the subject, a complex analysis was carried out, which includes such techniques as comparison, classification and evaluation. The research is relevant in the linguistic, social, national and cognitive aspects, as it demonstrates an interaction between language and society.