bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered hypothalamic microstructure in human obesity
Authors: Thomas K. , Beyer F. , Lewe G. , Zhang R. , Schindler S. , Schönknecht P. , Stumvoll M. , Villringer A. , Witte A.V. 
Published: March 2019

AbstractObesity is a multifactorial disorder driven by sustained energy imbalance. The hypothalamus is an important regulator of energy homeostasis and therefore likely involved in obesity pathophysiology. Animal studies suggest that obesity-related diets induce structural changes in the hypothalamus through inflammation-like processes. Whether this translates to humans is however largely unknown. Therefore, we aimed to assess obesity-related differences in hypothalamic macro- and microstructure based on a multimodal approach using T1-weighted and diffusion-weighted magnetic resonance imaging (MRI) acquired at 3 Tesla in a large well-characterized sample of the Leipzig Research Center for Civilization Diseases (LIFE) cohort (n1 = 338, 48% females, age 21-78 years, BMI 18-43 kg/m2). We found that higher body mass index (BMI) selectively predicted higher mean proton diffusivity (MD) within the hypothalamus, indicative of compromised microstructure in the underlying tissue. Results were independent from confounders and confirmed in another independent sample (n2 = 236). In addition, while hypothalamic volume was not associated with obesity, we identified a sexual dimorphism and larger hypothalamic volumes in the left compared to the right hemisphere. Using two large samples of the general population, we showed that a higher BMI specifically relates to altered microstructure in the hypothalamus, independent from confounders such as age, sex and obesity-associated co-morbidities. This points to persisting microstructural changes in a key regulatory area of energy homeostasis occurring with excessive weight. These findings may help to better understand the pathomechanisms of obesity and other eating-related disorders.
Feeding behavior of Aedes (Aedimorphus) vexans arabiensis, a Rift valley fever virus vector in the Ferlo pastoral ecosystem of Senegal
Authors: Biteye Biram , Fall Assane Gueye , Seck Momar Talla , Ciss Mamadou , Diop Mariame , Gimonneau Geoffrey 
Published: March 2019

AbstractHost-vector contact is a key factor in vectorial capacity assessment and thus the transmission of mosquito-borne viruses such as Rift Valley Fever (RVF), an emerging zoonotic disease of interest in West Africa. The knowledge of the host-feeding patterns of vector species constitutes a key element in the assessment of their epidemiological importance in a given environment. The aim of this work was to identify the blood meal origins of Aedes vexans arabiensis Patton (Diptera: Culicidae), the main vector of RVF virus in the Ferlo pastoral ecosystem of Senegal. Engorged female mosquitoes were collected in Younouféré in the pastoral ecosystem in the Ferlo region during the 2014 rainy season. CDC light CO2-baited traps were set at six sites for two consecutive nights every month from July to November. Domestic animals present around traps were identified and counted for each trapping session. Blood meal sources of engorged mosquitoes were identified using a vertebrate-specific multiplexed primer set based on cytochrome b. Blood meal sources were successfully identified for 319 out of 416 blood-fed females (76.68%), of which 163 (51.1%) were single meals, 146 (45.77%) mixed meals from two different hosts and 10 (3.13%) mixed meals from three different hosts. Aedes vexans arabiensis fed preferentially on mammals especially on horse compared to other hosts (P < 0.001). Proportions of single and mixed meals showed significant temporal (P < 0.001) and spatial variations (P < 0.001) according to hosts availability. Aedes vexans arabiensis shows an opportunistic feeding behavior depending on the host availability. Results were discussed in relation with the Rift valley fever virus transmission and vector involvement as well as its primary hosts.
Health service utilisation lags behind maternal diseases or illnesses during pregnancy in rural south Ethiopia: A prospective cohort study
Authors: Tadesse Moges , Loha Eskindir , Johansson Kjell Arne , Lindtjørn Bernt 
Published: March 2019

AbstractMaternal survival has improved substantially in the last decades, but evidence on maternal morbidity and health service utilisation for various maternal diseases are scarce in low resource settings. We aimed to measure health service utilisation for maternal illnesses during pregnancy. A cohort study of 794 pregnant women in rural southern Ethiopia was carried-out from May 2017 to July 2018. Disease or illness identification criteria were: symptoms, signs, physical examination, and screening of anaemia. Follow-up was done every two weeks. Data on health service utilisation was obtained from women and confirmed by visiting the health facility. Multilevel, multiple responses, repeated measures, and generalized linear mixed model analysis were used. The cumulative incidence of women experiencing illness episodes was 91%, and there were 1.7 episodes of diseases or illnesses per woman. About 22% of pregnant women were anaemic and 8% hypertensive. Fourteen pregnant women experienced abortions, 6 had vaginal bleeding, 48% pain in the pelvic area, 4% oedema, and 72% tiredness. However, health service utilisation was only 7%. About 94% of anaemic women did not get iron-folic-acid tablet supplementation. Only two mothers with blurred vision and severe headache were referred for further treatment. The main reasons for not using the health services were: the perception that symptoms would heal by themselves (47%), illness to be minor (42%), financial constraints (10%), and lack of trust in health institutions (1%). Risk factors were being older women, poor, having a history of abortion, living far away from the health institution, travelled longer time to reach a health institution, and monthly household expenditure >=30 USD. In Conclusion, there was a high incidence of diseases or illnesses; however health service utilisation was low. Poor understanding of severe and non-severe symptoms was an important reason for low health service utilisation. Therefore, community-based maternal diseases or illness survey could help for early detection. Ministry of Health should promote health education that encourages women to seek appropriate and timely care.
Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Authors: Soliai Marcus M. , Kato Atsushi , Stanhope Catherine T. , Norton James E. , Naughton Katherine A. , Klinger Aiko I. , Kern Robert C. , Tan Bruce K. , Schleimer Robert P. , Nicolae Dan L. , Pinto Jayant M. , Ober Carole 
Published: March 2019

AbstractBackgroundGenome-wide association studies (GWASs) have identified thousands of variants associated with asthma and other complex diseases. However, the functional effects of most of these variants are unknown. Moreover, GWASs do not provide context-specific information on cell types or environmental factors that affect specific disease risks and outcomes. To address these limitations, we used an upper airway (sinonasal) epithelial cell culture model to assess transcriptional and epigenetic responses to an asthma-promoting pathogen, rhinovirus (RV), and provide context-specific functional annotations to variants discovered in GWASs of asthma.MethodsUsing genome-wide genetic, gene expression and DNA methylation data in vehicle- and RV-treated airway epithelial cells (AECs) from 104 individuals, we mapped cis expression and methylation quantitative trait loci (cis-eQTLs and cis-meQTLs, respectively) in each condition. A Bayesian test for co-localization between AEC molecular QTLs and adult onset and childhood onset GWAS variants was used to assign function to variants associated with asthma. Mendelian randomization was applied to demonstrate DNA methylation effects on gene expression at asthma colocalized loci.ResultsCo-localization analyses of airway epithelial cell molecular QTLs with asthma GWAS variants revealed potential molecular disease mechanisms of asthma, including QTLs at the TSLP locus that were common to both exposure conditions and to both childhood and adult onset asthma, as well as QTLs at the 17q12-21 asthma locus that were specific to RV exposure and childhood onset asthma, consistent with clinical and epidemiological studies of these loci.ConclusionThis study provides information on functional effects of asthma risk variants in airway epithelial cells and insight into a disease-relevant viral exposure that modulates genetic effects on transcriptional and epigenetic responses in cells and on risk for asthma in GWASs.
Employers’ ratings of importance of skills and competencies college graduates need to get hired
Authors: Baird Anthony M. , Parayitam Satyanarayana 
Published: March 2019

PurposeHigher education institutions play an important role in the economic growth of any country, through skills and productivity of their graduates. Employers have some expectations about the skills the graduates possess when they graduate out of universities. The purpose of this paper is to examine the skills employers look for in graduates before they hire them.Design/methodology/approachUsing a structured survey instrument, this paper gathered data from 50 organizations employing over 50 people. The data consisted of 21 skills the employers rate as important. These skills were categorized into four dimensions: analytical skills, career professional and readiness skills, communications skills, and personality, leadership skills and team/group work. After checking the reliability of the scale, χ2 test and rank correlation were used to analyze the importance of these skills.FindingsThe findings from a study of employers in the northeastern part of USA suggest that the top six skills and competencies rated with highest importance by employers were: interpersonal skills/works well with others; critical thinking/problem-solving skills; listening skills; oral/speech communication skills; professionalism; and personal motivation. Of all 21 skills, the highly ranked skills needed were interpersonal skills followed by critical thinking and problem solving and listening.Research limitations/implicationsThe present research is based on self-report measures and, hence, the limitations of social desirability bias and common method bias are inherent. However, adequate care is taken to minimize these limitations. The research has implications for the higher educational institutions and researches in the field of education.Practical implicationsIn addition to the employers, this study contributes to higher educational institutions. The study suggests that employers look for interpersonal skills and problem-solving skills before making hiring decisions. Educational institutions need to focus on enhancing these skills in classrooms by emphasizing the teamwork. The implications for both academicians and practitioners are discussed in the paper.Social implicationsThe findings from the study help in creating a fruitful social environment in organizations.Originality/valueThis study provides new insights about the changing pattern of skills students need to secure before seeking employment.
Grey system analysis in the field of medicine and health
Authors: Lixia Zhang , Hong Tang , Miao He 
Published: March 2019

Purpose
The purpose of this paper is to predict hospital respiratory system infection rate by using the gray GM(1,1) model, and to provide theoretical basis for the prospective study on hospital respiratory system infection management.

Design/methodology/approach
The annual respiratory system infection rate of a comprehensive third-class hospital in Yan’an is collected from 2011 to 2017. The GM(1,1) model is used for prediction, and mean absolute percentage error is used to evaluate the prediction accuracy of the model.

Findings
GM(1,1) statistical prediction model is established with good fitting degree and high reliability of extrapolation prediction.

Originality/value
The GM(1,1) model can well predict the respiratory system infection rate of the hospital.
Talking about digital textbooks. The teacher perspective
Authors: Håkansson Lindqvist Marcia 
Published: March 2019

Purpose
An increasing amount of students’ and teachers’ work in the classroom involves digital technologies such as tablets and laptop computers. The purpose of this paper is to gain insight into the possibilities and challenges related to teachers’ use of digital textbooks and, through this work, the conditions for technology-enhanced learning (TEL).

Design/methodology/approach
This study was based on interviews with two teachers. In the analysis, The Ecology of Resources Model (Luckin, 2010) was used.

Findings
The findings of this study show that teachers see challenges in finding time to review digital textbooks and support the work with the textbooks in the classroom. However, the teachers in this study prioritize this work, seeing it as providing structure and improved accessibility for students.

Practical implications
The findings of this study point toward the need to support teachers in their work with reviewing and using digital textbooks, as well as other digitalized resources. How schools as organizations can support teachers’ activities, both individually and collaboratively, will be important. If this work is supported it may, in turn, have impact on TEL and promoting students’ use of digital textbooks and improving student outcomes.

Originality/value
This small study provides interesting insights into how teachers prioritize their work with digital textbooks to, despite challenges related to time, individualize and support students’ work with digital textbooks and other digital resources. Research on teachers’ use of digital textbooks in practice is limited.
Research trends in the study of gamification
Authors: Alsawaier Raed S. 
Published: March 2019

Purpose
The purpose of this paper is to examine the research design of several publications on the study of gamification and proposes a mixed-method research design for creating a holistic understanding of the gamification phenomenon. It presents an argument in support of combining both qualitative and quantitative data sources through mixed-method design as being equally important in illuminating all aspects of the research problem.

Design/methodology/approach
The paper covers a number of methodological themes relevant to the study of gamification: research design trends in the study of gamification; the importance of mixed-method design in the study of gamification; methodological challenges; conclusion and recommendations.

Findings
Majority of the studies on gamification before 2015 are either quantitative or described as mixed method but overly focused on quantitative data sources. However, there is a tendency between 2015 and 2017 to adopt mixed-method design.

Research limitations/implications
The study does not examine all research done on the topic of gamification but relies on 56 empirical studies reviewed by Hamari, Koivisto, Sarsa (2014) and Seaborn and Fels (2015) between 2009 and 2015.

Originality/value
The author believes it to be one of the few studies of its kind on proposing a methodological design for the study of gamification as a pedagogical tool.
Competency based superior performance and organizational effectiveness
Authors: Shet Sateesh V. , Patil S.V. , Chandawarkar Meena R. 
Published: March 2019

PurposeThe purpose of this paper is to explore the relationship between competency-based performance management and organizational effectiveness (OE). It signifies the importance of developing competency-based performance concept in organizations. Since conventional performance management systems (PMSs) are diminishing and as organizations are looking for breakthrough PMSs, this research attempted to fill the gap from stakeholder’s perspective – employee, manager and organization in devising new approach in PMS.Design/methodology/approachThe research design involved developing scale for “competency-based superior performance” and validating scale for “organizational effectiveness,” The data for this survey are collected from 292 respondents through structured questionnaire. Hypotheses depicting aforementioned relationships were empirically tested in the context of competency-based performance practices in organizations based in India. Structural equation modeling (SEM) technique was used for data analysis.FindingsThe empirical results provide methods to accelerate the performance management initiatives based on a leadership competency model (LCM), which are necessary for building performance culture in the organization. The paper contributes by developing a new scale for measuring competency-based performance practices. The scale for OE is revisited. A positive relationship between competency-based superior performance and OE with productivity, adaptability and flexibility has been empirically confirmed using SEM.Research limitations/implicationsThe paper limits the performance measurement concept using leadership competencies.Practical implicationsThe developed model will act as a building block for performance measurement in organizations. This paper promotes LCM to be applied in creating a performance-based culture.Originality/valueThis is a unique attempt to test the relationship between competency-based performance management and OE.
Exploring primary care responses to domestic violence and abuse (DVA): operationalisation of a national initiative
Authors: McGarry Julie , Hussain Basharat , Watts Kim 
Published: March 2019

PurposeIn the UK, the Identification and Referral to Improve Safety (IRIS) initiative has been developed for use within primary care to support women survivors of domestic violence and abuse (DVA). However, while evaluated nationally, less is known regarding impact of implementation at a local level. The purpose of this paper is to explore the effectiveness of IRIS within one locality in the UK.Design/methodology/approachA qualitative study using interviews/focus groups with primary care teams and women who had experienced DVA in one primary care setting in the UK. Interviews with 18 participants from five professional categories including: general practitioners, practice nurses, practice managers, assistant practice managers and practice receptionists. Focus group discussion/interview with seven women who had accessed IRIS. Data were collected between November 2016 and March 2017.FindingsFive main themes were identified for professionals: Team role approach to training, Professional confidence, Clear pathway for referral and support, Focussed support, Somewhere to meet that is a “safe haven”. For women the following themes were identified: Longevity of DVA; Lifeline; Face to face talking to someone; Support and understood where I was coming from; A place of safety.Practical implicationsIRIS played a significant role in helping primary care professionals to respond effectively. For women IRIS was more proactive and holistic than traditional approaches.Originality/valueThis study was designed to assess the impact that a local level implementation of the national IRIS initiative had on both providers and users of the service simultaneously. The study identifies that a “whole team approach” in the primary care setting is critical to the effectiveness of DVA initiatives.
Long and winding road?
Authors: Csillag Sara , Gyori Zsuzsanna , Svastics Carmen 
Published: March 2019

Purpose
The purpose of this paper is to explore and analyse the barriers entrepreneurs with disabilities (EWD) face when establishing their own enterprises, as well as the supporting factors in starting and running a business.

Design/methodology/approach
This is an explorative study. Data were collected using semi-structured interviews with ten Hungarian entrepreneurs with physical disabilities or sight-loss, during the summer of 2018.

Findings
The paper classifies the barriers and supporting factors, as personal, economic and social. Based on the perceptions of the entrepreneurs, personal characteristics, identity and various types of family support play an important role in becoming entrepreneurs, but the entrepreneurial ecosystem generally is not favourable in Hungary, and there are no special support programmes focussing on EWD.

Research limitations/implications
Sample size is a serious limitation: the ten entrepreneurs do not represent in any sense the entire EWD community in Hungary, so the patterns found cannot be considered a generally valid picture.

Originality/value
The article contributes to the literature on entrepreneurship and disabilities, especially through the systematic review of the possible barriers and supporting factors and to the existing empirical body of knowledge by shedding light on the barriers and supporting factors in a rarely investigated region, in Central Europe: Hungary.
SEC sues asset managers for using untested, error-filled quantitative investment models
Authors: Cohen Wendy E. , Marshall Richard D. , Yacker Allison C. , Zinman Lance A. 
Published: March 2019

Purpose
To explain actions the US Securities and Exchange Commission (SEC) brought on August 27, 2018, against a group of affiliated investment advisers and broker-dealers for what the SEC considered misleading and insufficient representations and disclosures, insufficient compliance policies and procedures, and insufficient research and oversight concerning the use of faulty quantitative models to manage certain client accounts.

Design/methodology/approach
Explains the SEC’s findings concerning the advisers’ and broker-dealers’ failure to confirm that certain models worked as intended, to disclose the risks associated with the use of those models, to disclose the role of a research analyst in developing the models, to disclose the use of volatility overlays along with the associated risks, to determine whether a fund’s holdings were sufficient to support a consistent dividend payout without a return of capital, and to take sufficient steps to confirm the advertised performance of another investment manager whose products they were marketing. Provides insight into the SEC’s position and offers key takeaways.

Findings
These cases are significant for advisers who use quantitative models to implement their investment strategies in the management of client accounts and signal the SEC’s continued focus on investment advisers’ compliance with disclosure obligations to discretionary account investors.

Practical implications
Each manager should consider its own facts and circumstances, and should consult with counsel, in assessing how and to what extent to incorporate the SEC’s conclusions in crafting disclosure and other communications with investors on matters such as adequate representations, testing and validation of models, disclosure of errors, and verifying performance claims.

Originality/value
Practical guidance from experienced securities lawyers.