bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sn Penetrated Zincophilic Interface Design in Porous Zn Substrate for High Performance Zn‐Ion Battery
Authors: Han Wangyang , Tan Yihong , Ni Liping , Sun Ximei , Li Kunzhen , Lu Leilei , Zhang Hui 
Published: November 2024

AbstractRechargeable zinc‐ion batteries are considered an ideal energy storage system due to their low cost and nonflammable aqueous electrolyte. However, dendrite growth, hydrogen evolution reaction, and self‐corrosion of zinc anode brought about serious safety risks including short circuits and electrode expansion. Therefore, a modified host‐design strategy with a 3D porous structure and bulk‐phase penetrated zincophilic interface is proposed to boost the stability and lifetime of the Zn anode. The porous Zn substrate is constructed by universal HCl etching and the uniform and tight Sn‐penetrated zincophilic interface is formed by effective electron beam evaporation (EBE). The porous substrate can uniform zinc ion flux and the Sn coating could effectively improve zinc ion deposition behavior, thus inhibiting the risk of dendrites growth and side reaction. As a result, the 3D Zn substrate with Sn interface (3D Zn@Sn) exhibits prolonged galvanostatic cycling performance up to 4500 h with a low polarization of ≈25 mV (1 mA cm−2, 1 mAh cm−2) in the symmetric cell. The full cell assembled with KVOH@Ti could maintain a high specific capacity of 148.6 mAh g−1 after 500 galvanostatic cycles (10 A g−1). This work proposed an improved electrode design to realize the high performance of zinc ion batteries.
Dissociation Constant (Kd) Measurement for Small‐Molecule Binding Aptamers: Homogeneous Assay Methods and Critical Evaluations
Authors: Stangherlin Stefen , Ding Yuzhe , Liu Juewen 
Published: November 2024

AbstractSince 1990, numerous aptamers have been isolated and discovered for use in various analytical, biomedical, and environmental applications. This trend continues to date. A critical step in the characterization of aptamer binding is to measure its binding affinity toward both target and non‐target molecules. Dissociation constant (Kd) is the most commonly used value in characterizing aptamer binding. In this article, homogenous assays are reviewed for aptamers that can bind small‐molecule targets. The reviewed methods include label‐free methods, such as isothermal titration calorimetry, intrinsic fluorescence of target molecules, DNA staining dyes, and nuclease digestion assays, and labeled methods, such as the strand displacement reaction. Some methods are not recommended, such as those based on the aggregation of gold nanoparticles and the desorption of fluorophore‐labeled DNA from nanomaterials. The difference between the measured apparent Kd and the true Kd of aptamer binding is stressed. In addition, avoiding the titration regime and paying attention to the time required to reach equilibrium are discussed. Finally, it is important to include mutated non‐binding sequences as controls.
Local haplotyping reveals insights into the genetic control of flowering time variation in wild and domesticated soybean
Authors: Mohamedikbal Shameela , Al‐Mamun Hawlader A. , Marsh Jacob I. , Upadhyaya Shriprabha , Danilevicz Monica F. , Nguyen Henry T. , Valliyodan Babu , Mahan Adam , Batley Jacqueline , Edwards David 
Published: November 2024

AbstractThe timing of flowering in soybean [Glycine max (L.) Merr.], a key legume crop, is influenced by many factors, including daylight length or photoperiodic sensitivity, that affect crop yield, productivity, and geographical adaptation. Despite its importance, a comprehensive understanding of the local linkage landscape and allelic diversity within regions of the genome influencing flowering and contributing to phenotypic variation in subpopulations has been limited. This study addresses these gaps by conducting an in‐depth trait association and linkage analysis coupled with local haplotyping using advanced bioinformatics tools, including crosshap, to characterize genomic variation using a pangenome dataset representing 915 domesticated and wild‐type individuals. The association analysis identified eight significant loci on seven chromosomes. Moving beyond traditional association analysis, local haplotyping of targeted regions on chromosomes 6 and 20 identified distinct haplotype structures, variation patterns, and genomic candidates influencing flowering in subpopulations. These results suggest the action of a network of genomic candidates influencing flowering time and an untapped reservoir of genomic variation for this trait in wild germplasm. Notably, GlymaLee.20G147200 on chromosome 20 was identified as a candidate gene that may cause delayed flowering in soybean, potentially through histone modifications of floral repressor loci as seen in Arabidopsis thaliana (L.) Heynh. These findings support future functional validation of haplotype‐based alleles for marker‐assisted breeding and genomic selection to enhance latitude adaptability of soybean without compromising yield.
Toward Environmental Sustainability in Africa: The Impact of Financial Technology, Human Development, and Renewable Energy Consumption Across Income Groups
Authors: Oben Remy , Seraj Mehdi , Eyüpoğlu Şerife Zihni 
Published: November 2024

ABSTRACTThe United Nation's Sustainable Development Goal 13 (“Climate Action”) aims to address the issues of global warming and climate change, primarily caused by greenhouse gas emissions. This study examines the impacts of financial technology, human development, economic growth, and renewable energy consumption on environmental quality from 2013 to 2019 in African nations classified into different income groups. Using the method of moments quantile regression (MMQR) technique, results show that economic growth and human development (renewable energy consumption and financial technology) increase (decrease) carbon dioxide emissions in the long run. These imply that in the absence of sustainable practices, pursuing economic growth and human development could degrade the environment, while transitioning to renewable energy and promoting fintech could improve environmental quality. This study makes five major scientific contributions in terms of research question (unique combination of variables), sample (carbon emission‐financial technology nexus in Africa), proxy for financial technology (“credit flows by fintech and big tech companies to GDP (%)”), MMQR estimation technique (for the first time in this context), and comparative analysis based on income‐group classification. This study recommends the implementation of sustainable development frameworks, the adoption of green technologies, the transition from nonrenewable to renewable energy sources, the widespread education and awareness on environmental effects, and the encouragement of sustainable fintech solutions to help African countries attain sustainable economic growth and human development while reducing their carbon footprints.
Hexavalent Chromium Adsorption on Adsorbent Derived From Biomass of Fabaceae Plant in Vietnam: Effect of Preparation Conditions on Equilibrium Adsorption Capacity
Authors: Vu Thai Phuong , Quyen Lam Thi Thanh , Hiep Nguyen Trung , Thu Ta Thi Hoai , Suong Tran Tuyet 
Published: November 2024

ABSTRACTThe present work is devoted to examining the potential of Sesbania sesban biochar produced through slow pyrolysis for 120 min at 300°C in removing hexavalent chromium from the aqueous phase. The physicochemical characteristics of biochar were analyzed utilizing a variety of analytical tools including SEM, BET, and FTIR. Results revealed that the biochar had a smooth surface, an even stacking pattern with a porous texture, a large BET surface area equal to 562 m2/g, and a pHpzc of 6.9. The biochar efficiency in eliminating Cr (VI) was investigated through several variables, including biochar dosage (0.1–0.4 g), pH (2–8), initial chromium ion concentration (10–40 mg/L), and adsorption time (15–120) min. The results identified the best conditions for adsorbing Cr (VI): an initial concentration of 10 mg/L, an absorbent dosage of 0.3 g, a pH solution of 2, and a reaction time of 90 min. The experiment achieved a Cr (VI) removal efficiency of over 90% by applying these conditions. The adsorption isotherm data were analyzed and showed a strong correlation coefficient (R2 = 0.985) for Langmuir monolayer model, in which the maximum adsorption capacity achieved was 5.3 mg/g. According to the kinetic investigation, the adsorption of Cr (VI) was adapted to a pseudo‐second‐order model having a high R2 value of 0.998. These results demonstrate that Sesbania sesban biochar has excellent potential as a cost‐effective and highly efficient adsorbent for removing hexavalent chromium and improving water quality.
Sex‐related differences in the presentation, management and response to treatment of eosinophilic esophagitis: Cross sectional analysis of EoE CONNECT registry
Authors: Laserna‐Mendieta Emilio J. , Casabona‐Francés Sergio , Amorena Edurne , Savarino Edoardo V. , Pérez‐Martínez Isabel , Blas‐Jhon Leonardo , Guardiola‐Arévalo Antonio , Coletta Marina , Pellegatta Gaia , Guagnozzi Danila , Barrio Jesús , Perello Antonia , Betoré Elena , Krarup Anne Lund , Votto Martina , Gutiérrez‐Junquera Carolina , Naves Juan Enrique , Oliva Salvatore , Teruel Sánchez‐Vegazo Carlos , Carrión Silvia , Riva Susana de la , Espina‐Cadenas Silvia , Fernández‐Fernández Sonia , Llorente‐Barrio Mónica , Pascual‐Lopez Irene , Masiques‐Mas María Luisa , Honrubia‐López Raúl , Dainese Raffaella , García‐Morales Natalia , Cobian Julyssa , Bisso‐Zein Juan Khaled , Roales Valentín , Juan‐Juan Alba , Rodríguez‐Sánchez Alba , Feo‐Ortega Sara , Martín‐Domínguez Verónica , Nantes‐Castillejo Óscar , Nicolay‐Maneru Julia , Ghisa Matteo , Maniero Daria , Suarez Adolfo , Maray Iván , Álvarez‐García Marta , Granja‐Navacerrada Alicia , Penagini Roberto , Racca Francesca , Llerena‐Castro Ronald , Santander Cecilio , Arias Ángel , Lucendo Alfredo J. ,   EUREOS and EoE CONNECT research group
Published: November 2024

AbstractBackgroundEosinophilic esophagitis (EoE) predominantly affects males across all ages; however, little is known about sex differences for other aspects of EoE.ObjectiveTo investigate associations between sex and clinical presentation, endoscopic features, treatment choice and response in EoE patients in real‐world practice.MethodsCross‐sectional analysis of the multicenter EoE CONNECT registry. The independent contribution of patients' sex and other relevant variables were statistically assessed by multivariate models.ResultsA total of 2976 patients (76% male) were evaluated. Males were diagnosed at a younger age compared to females (32.7 ± 14.8 vs. 34.8 ± 15.6 years, respectively; p = 0.002) with similar diagnostic delay. EoE symptoms varied significantly between sexes, with food impaction predominating in males and dysphagia, heartburn, regurgitation and abdominal and epigastric pain in females. However, female sex contributed to higher symptom severity at diagnosis as measured with Dysphagia Symptom Score (R2 = 0.57; p = 0.013) and presented higher peak eosinophil count in esophageal biopsies (p = 0.005). Males showed increased risk of stricturing or mixed phenotypes (adjusted OR 1.43, 95%CI:1.05–1.96; p = 0.024). No association was found between patients’ sex and first‐line treatment modality: proton pump inhibitors (PPI) were preferred over topical corticosteroids in patients with inflammatory phenotypes instead of stricturing or mixed phenotypes, and in patients who did not present food impaction. Both topical corticosteroids and dietary interventions were preferred over PPI in pediatric patients regardless of sex.ConclusionsSex is associated with clinical and phenotypical presentation of EoE at diagnosis, with more fibrotic findings in males but higher symptom score in females.
Mucin 18‐targeted humanized monoclonal antibody immune positron emission tomography imaging and patient‐derived tumor xenograft visualization
Authors: Zhang Qian , Du Haizhen , Ma Xiuli , Liu Song , Kong Xiangxing , Hu Muye , Shi Jing , Tang Yanfang , Liu ShuHui , Meng Xun , Guo Qian , Kong Yan , Guo Jun , Lian Bin , Yang Zhi , Zhu Hua 
Published: November 2024

AbstractIn the context of precision diagnosis for various subtypes of melanoma, identifying biomarkers with clinical translational potential from a molecular standpoint is crucial for a more comprehensive characterization of the disease. Mucin 18 (MUC18) is highly expressed in both tumor cells and tumor vasculature in major melanoma subtypes and is restricted to normal tissues. A noninvasive imaging approach for MUC18 in melanoma utilizing an immune positron emission tomography (PET) radionuclide‐conjugated drug (RDC) with an 89Zr‐labeled humanized anti‐MUC18 monoclonal antibody (mAb) was developed. A375, Sk‐Mel‐28, HMVII, and A549 cells and tumor model mice were conducted. Immuno‐PET was employed to assess the specificity and targeting of three distinct melanoma cell line‐derived xenografts (CDXs) and patient‐derived tumor xenografts (PDXs) in immunodeficient mice. The developed RDC, named 89Zr‐IP150, demonstrated robust in vitro stability and high binding affinity, ensuring reliable and specific PET imaging of small, medium, and large subcutaneous tumors in human melanoma mouse xenotransplantation models. Notably, for the first time, the clinical translational potential of 89Zr‐IP150 was successfully validated using PDX models. These findings present a noninvasive, real‐time method for the early screening of MUC18 (+) melanoma patients and are important for studying the early‐stage biological distribution of MUC18‐targeted antibody‐drug conjugates.
Battling for food security in Africa: Is climate finance the missing bullet?
Authors: Kelly Arsene Mouongue 
Published: November 2024

AbstractAs climate change increasingly threatens food production and distribution in Africa, understanding how climate finance programs can effectively improve food security in the region has become a critical research priority. In this light, the present study investigates the effect of climate finance on food security across 37 African countries from 2012 to 2021, utilizing secondary data and employing the system generalized method of moments. Our findings consistently demonstrate that climate finance plays a significant role in reducing food insecurity in Africa. This effect remains robust across various alternative food insecurity and climate finance metrics. Furthermore, through analyses of transmission channels, we confirm the indirect pathways through which climate finance contributes to improved food security outcomes in the region. Based on the findings, the study recommends strengthening and expanding climate finance initiatives focusing on enhancing accessibility, equity, and targeted support for farmers to reduce food insecurity.
Association of commission on cancer accreditation with receipt of guideline‐concordant care and survival among patients with colon cancer
Authors: Chan Kelley , Palis Bryan E. , Cotler Joseph H. , Janczewski Lauren M. , Weigel Ronald J. , Bentrem David J. , Ko Clifford Y. 
Published: November 2024

AbstractBackgroundGuideline‐concordant care (GCC) is associated with improved survival for patients with cancer; however, variations in receipt of GCC remain a concern. The objective of this study was to evaluate the association of Commission on Cancer (CoC) hospital accreditation status with receipt of GCC and survival among patients with colon cancer.MethodsThis retrospective observational study identified patients diagnosed with stage I–IV colon cancer from 2018 to 2020 from the National Program of Cancer Registries and Surveillance, Epidemiology, and End Results Program Database. Guideline concordance was defined as receipt of stage‐appropriate lymphadenectomy or chemotherapy. Multivariable logistic regression models investigated associations with receipt of GCC. Cox proportional hazards regression models assessed 3‐year cancer‐specific mortality risk.ResultsOf 222,583 patients with colon cancer, 146,629 (91.2%) of eligible patients received guideline‐concordant lymphadenectomy and 70,586 (81.9%) of the eligible patients received guideline‐concordant chemotherapy. Treatment at CoC‐accredited hospitals was the strongest modifiable predictor for receipt of guideline‐concordant lymphadenectomy (odds ratio [OR] 1.82; 95% confidence interval [CI] 1.75–1.88) and chemotherapy (OR 2.14; 95% CI 2.06–2.23). Among patients treated at CoC‐accredited hospitals, risk adjusted mortality was decreased for patients with stage I–II disease (hazard ratio [HR] 0.94; 95% CI 0.80–0.99), stage III disease (HR 0.93; 95% CI 0.88–0.98), and stage IV disease (HR 0.88; 95% CI 0.84–0.92).ConclusionsFor patients with colon cancer, treatment at CoC‐accredited hospitals was associated with increased receipt of GCC and decreased mortality risk. Benchmarking data may serve as a valuable accountability tool for quality assessment to improve cancer treatment and outcomes.
Unsteady flow rate in transient, incompressible pipe flow
Authors: Brumand‐Poor Faras , Kotte Tim , Pasquini Enrico , Kratschun Filipp , Enking Joscha , Schmitz Katharina 
Published: November 2024

AbstractKnowledge regarding current flow rates through pipes and other components is crucial for most hydraulic systems. The hydraulic power can be computed in combination with the pressure, which may be used in many applications, such as predictive maintenance. Most flow rate sensors used in the field of fluid power operate invasively. Therefore, the measurement process itself alters the flow rate. Furthermore, most sensors operate accurately for stationary flow but produce inaccurate measurements for transient flow. A well‐known method of determining the flow rate is to measure the pressure difference between two points along a pipeline and calculate the flow rate based on the law of Hagen and Poiseuille. However, since the relation mentioned above only applies to laminar, steady, and incompressible flow, its usefulness for transient flows is limited. This paper derives a system equation based on the fundamental laws of fluid mechanics, which describe transient, incompressible pipe flow. As a result, the fundamental equations are solved in the Laplace domain and subsequently transformed back into the time domain. The four‐pole theorem relates the pressure difference and the volumetric flow rate. The analytical solution consists of a convolution integral containing a weighting function and the pressure difference. Compared to a simulation, the novel equation displays high accuracy for transient and stationary incompressible pipe flow. This equation paves the way for a soft sensor, which allows the noninvasive measurement of arbitrary volumetric flow rates within pipes.
Impact of microorganisms on Blasius–Rayleigh–Stokes flow and heat transfer of nanofluid: A numerical study
Authors: Ahmad Adeel , Nawaz Rab , Ali Aamir , Alruwaili Abdulmohsen Daham 
Published: November 2024

AbstractIn this article, we present a numerical study of unsteady flow and heat transfer in a viscous‐based nanofluid, examining the impact of microorganisms on a moving surface emerging from a moving slot. This gives rise to a new type of boundary layer flow, which can resemble that over a stretching or shrinking surface depending on the motion of the slot. To solve the partial differential equations governing the bio‐convectional flow, we employ the Blasius–Rayleigh–Stokes variable and transform the equations into a corrected similar form. Our numerical solutions reveal the presence of dual solutions within a specific range of the moving slot parameter. Our findings have important implications for understanding the behavior of nanofluids and microorganisms in dynamic flow environments.
A Study on Function Concept among Freshmen in Senior High School in Inner Mongolia and Suggestions to Textbook Compilation
Authors: Dang Guoqiang , Guo Yufeng 
Published: November 2024

AbstractThe concept of function is the first important and difficult knowledge that high school students encounter when learning mathematics. The purpose of this study was to examine the understanding of the concept of function among freshmen at a senior high school in Inner Mongolia, China. This study adopted a combination of a questionnaire and a test concerning the concept of function in senior high school. The results show that freshmen have the following problems in the understanding of function concepts: understanding of the correspondence definition of function concepts is not thorough enough, the understanding of the concept and interrelationship of the three elements of functions is not deep enough, and there are major problems in understanding whether two functions are the same function, the graphics, and domain of abstract functions. Finally, provide suggestions to mathematics textbook writers to improve the content of function concepts.
A Comparative Study of the U.S. Evaluation Criteria for Quality Instructional Materials Tool—Grades 1–5 as an Example
Authors: Li Xiaomeng , Zhao Xinyi , Kong Fanzhe 
Published: November 2024

AbstractAs a guiding document for the development, publication, distribution and selection of teaching materials, the evaluation standards for teaching materials are of great significance in ensuring the quality and guiding the healthy development of teaching materials. EdReports.org, a private, independent, non-profit organization that develops and publishes the Quality Instructional Materials Tool： K-8 Mathematics (QIMT) based on the original vision of “equity, excellence, and support for teachers”, which provides standards for evaluating mathematic materials for grades K-12. In this paper, we conduct an in-depth study of the background and original intention, framework and content, process and approach of the QIMT (1~5), and finally conclude three experiences and insights that can be used for reference in our country.
A Comparative Analysis on the “Arbitrary Angle and Radian System” Content of China and America
Authors: Ma Tianhui , Zhang Qiuyi 
Published: November 2024

AbstractThis paper analyzes the content of “Arbitrary angle and radian system” in Chinese and American high school mathematics textbooks from macro and micro levels. At the macro level, curriculum standards and content range are compared, while at the micro level, concept learning, exercises and mathematical history are compared. The results show that compared with American mathematics textbooks, Chinese mathematics textbooks pay more attention to the cultivation of students’ “basic knowledge and ability” rather than inquiry ability. Chinese textbooks respect the logic of mathematical knowledge and emphasize the expression of mathematical language in concepts and exercises, while American textbooks are more reflective of real life. Chinese textbooks are more closely related to knowledge than American textbooks. Finally, some suggestions are put forward.
The Potentially Implemented Spiral Curriculum: A 3-Feature Analysis of Geometry Textbook Chapters
Authors: Punzal Chara Deanna F. , Aberin Maria Alva Q. , Francisco Flordeliza F. 
Published: November 2024

AbstractSince the Philippine K-12 reform in 2012, textbooks now follow a Spiral Progression Approach (SPA) across grade levels. This content analysis investigated the manifestations of the 3 features of a spiral curriculum: (1) revisit of topics, (2) increase in difficulty level, and (3) relating to pre-requisite knowledge, in math textbooks. Combining frameworks, the study analysed the discussions, examples, and exercises of the geometry chapters of 4 textbooks (1 series for junior high school). It was found that topic discussions were more repetitive than spiralling. Majority of the examples and exercises were also focused on low difficulty levels, thus leading to underdeveloped competency. The study reinforces the integral role of textbooks and crafting resources with the SPA features in mind to help in the implementation of the K-12 curriculum.