bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue Expansion of Dental Extraction Sockets Using Dehydrated Human Amnion/Chorion Membrane: Case Series
Authors: Maksoud Mohamed A. , Guze Kevin A. 
Published: August 2018

IntroductionPrimary closure of augmented extraction sockets is one of the most challenging procedures in oral surgery as it requires vertical releasing incisions and undermining of the buccal mucosa to establish primary closure. This commonly used technique has been successful in wound closure; however, it has the disadvantage of loss of the buccal keratinized tissue due to flap positioning towards the lingual flap edges.Case PresentationThis case series demonstrates the effectiveness of the dehydrated human amnion/chorion membrane (dHACM) in increasing the attached keratinized tissue over augmented extraction socket wounds and thus expanding the tissue. Patients with posterior extraction sockets were treated using the same bone graft material. The distance between the buccal and lingual flaps was measured and recorded. The dHACM was tucked underneath the buccal and lingual flaps by approximately 2 to 3 mm, secured with sutures, and left to heal. Postoperative visits were scheduled at 2‐, 4‐, and 12‐week intervals for observation of the healing and treatment of any complications.ConclusionsAt 12 weeks postoperative, the amount of bucco‐lingual attached keratinized tissue was measured on the horizontal ceiling of the healed extraction socket and recorded. It showed gain in the keratinized tissue on top of the bone graft when the membrane was used. Although the membrane was exposed, no loss of the bone graft material was reported.
Highly Enantioselective Synthesis and Anticancer Activities of Chiral Conjugated Diynols
Authors: Zhang Ke , Zhang Chun , He Zhong‐Hong , Huang Jian , Du Xi , Wang Li , Wei Si‐Ping , Pu Lin , Wang Qin 
Published: August 2018

AbstractA chiral amino alcohol based ligand was found to promote the highly enantioselective addition of terminal conjugated diynes to aromatic and aliphatic aldehydes. The combination of easily available C2‐symmetric (R)‐ and (S)‐BINOL with Ti(OiPr)4, Zn powder, and EtI was also found to catalyze the asymmetric addition of 1,3‐diynes to aldehydes under mild reaction conditions, and thus, both enantiomers of the chiral conjugated diynols could be prepared with high enantioselectivities. The resulting optically active conjugated diynols were found to have potential anticancer activities with significant differences against HepG2 and HeLa cancer cells, and remarkable enantioselective cytotoxicity was observed for the first time.
Whole wheat noodle: Processing, quality improvement, and nutritional and health benefits
Authors: Niu Meng , Hou Gary G. 
Published: August 2018

AbstractBackground and objectivesThe popularity of Asian noodles is increasing around the world, and the introduction of noodle products made from whole grain flour is considered as an effective way to modify customer's dietary pattern and promote high‐fiber food consumption. This review summarizes the processing technologies, quality improvement techniques, and nutritional and health benefits of whole wheat noodles (WWN).FindingsFresh raw noodles, dried noodles, and instant noodles are the major types of WWN. They contain various formulations and processing procedures. The quality attributes of flour qualities, color, shelf life, cooking performance, textural attributes, and sensory properties are particularly emphasized for WWN quality improvements. The improving techniques include wheat selection, flour/bran particle size control, functional ingredient use, and some emerging technologies. WWN possess a superior nutritive value than refined noodle products.ConclusionsWhole wheat noodles have great potential for delivering a stable food with high nutritional values and desirable eating qualities. It is important for the manufactures to select the proper processing technologies and improvement techniques for various WWN.Significance and noveltyThe review highlights the differences in the processing technology of WWN and demonstrates the quality improvement techniques and nutritional and health benefits. It contributes to the expansion of knowledge on WWN and provides valuable guidance for the further improvement of WWN.
First Demonstration of Magnetoelectric Coupling in a Polynuclear Molecular Nanomagnet: Single‐Crystal EPR Studies of [Fe3O(O2CPh)6(py)3]ClO4⋅py under Static Electric Fields
Authors: Boudalis Athanassios K. , Robert Jérôme , Turek Philippe 
Published: August 2018

AbstractSingle‐crystal EPR experiments show that the highly symmetric antiferromagnetic half‐integer spin triangle [Fe3O(O2CPh)6(py)3]ClO4⋅py (1, py=pyridine) possesses a ST=1/2 ground state exhibiting high g‐anisotropy due to antisymmetric exchange (Dzyaloshinskii–Moriya) interactions. EPR experiments under static electric fields parallel to the triangle's plane (i.e., perpendicular to the magnetic z‐axis) reveal that this ground state couples to externally applied electric fields. This magnetoelectric coupling causes an increase in the intensity of the intradoublet EPR transition and does not affect its resonance position when B0∥z. The results are discussed on the basis of theoretical models correlating the spin chirality of the ground state with the magnetoelectric effect.
Room‐Temperature Ionic‐Liquid‐Assisted Microwave Preparation of Tunable Photoluminescent Copper‐Indium‐Zinc‐Sulfide Quantum Dots
Authors: Chen Ting , Xu Yanqiao , Wang Lianjun , Jiang Weihui , Jiang Wan , Xie Zhixiang 
Published: August 2018

AbstractA facile approach towards photoluminescent (PL) Cu‐In‐Zn‐S quantum dots (CIZS QDs) has been developed, comprising microwave treatment with the assist of room‐temperature ionic liquid (RTIL). Because of its high polarizability, RTIL served as a microwave absorbent, which resulted in the increase of the instantaneous nucleation rate and the rapid synthesis of CIZS QDs at low temperature. Moreover, the surface decoration of QDs with RTIL can passivate the surface defects greatly. The PL intensity of the CIZS QDs depends on the anion species, alkyl chain length of the RTIL, and the metal element ratios of the QDs. On the basis of the variable PL peak position and extended luminescence lifetime of the CIZS QDs, the superior emission behavior of the QDs was confirmed by surface etching with fluoride produced by the hydrolysis of RTIL 1‐butyl‐3‐methylimidazolium tetrafluoroborate ([Bmim]BF4). Moreover, the intermediate alkyl chain length of the RTIL can avoid aggregation, which results in the construction of CIZS QDs with homogenous size distribution. The shape‐controlled CIZS QDs show a broadened tunable emission peak from 677 to 579 nm compared with that of QDs prepared by a conventional one‐pot method by mixing the raw materials. CIZS QDs also exhibit a high quantum yield (QY) of 24.1 % after coating with a ZnS shell. This method is expected to be a useful technique for the rapid synthesis of multiple QDs with a wider range of emission wavelengths and higher QY for a variety of applications.
Rhodium Complexes of a New‐Generation Sapphyrin: Unique Structures, Axial Chirality, and Catalysis
Authors: Chen Qiu‐Cheng , Saltsman Irena , Kaushansky Alexander , Xiao Zi‐Ye , Fridman Natalia , Zhan Xuan , Gross Zeev 
Published: August 2018

AbstractRhodium insertion into the new 5,10,15,20‐tetrakis(trifluoromethyl)sapphyrin was found to be much more facile than for other analogues, owing to NH⋅⋅⋅F hydrogen‐bonding interactions that stabilise the pyrrole‐inverted structure characteristic of the metallated product. The thus‐obtained rhodium(I) complexes have axial chirality, and the enantiomers were resolved. The latter were found to interconvert quite rapidly in a process that involves a tautomerisation‐like movement of the metal fragment between the five N atoms. The rhodium sapphyrins were investigated as catalysts for organic synthesis, by studying their carbene‐transfer activity in the cyclopropanation of styrene with ethyl diazoacetate and comparing it to that of rhodium corroles.
Expedient Access to 2‐Benzazepines by Palladium‐Catalyzed C−H Activation: Identification of a Unique Hsp90 Inhibitor Scaffold
Authors: Virelli Matteo , Moroni Elisabetta , Colombo Giorgio , Fiengo Lorenzo , Porta Alessio , Ackermann Lutz , Zanoni Giuseppe 
Published: August 2018

AbstractBioactive 2‐benzazepines were accessed in an atom‐ and step‐economical manner through a versatile palladium‐catalyzed C−H activation strategy. The C−H arylation required low catalyst loading and a mild base, which was reflected by a broad scope and high functional‐group tolerance. The benzotriazolodiazepinones were identified as new heat shock protein 90 (Hsp90) inhibiting lead compounds, with considerable potential for anti‐cancer applications.
The importance of considering skin diseases from a temporal perspective: Special emphasis on the effects of corticosteroids and virally induced diseases
Authors: Shiohara Tetsuo , Mizukawa Yoshiko 
Published: August 2018

AbstractThe efficacy and safety of medical therapies assessed on the basis of short‐term outcomes are often considered to inform the long‐term outcomes. Even in corticosteroid therapy, either systemic or topical, which is most frequently used as a first‐line therapy to control inflammation, few studies have reported the risk/benefit ratio for long‐term outcomes. Thus, a temporal perspective should be added to our conventional understanding of the effectiveness of medical therapies. In this review, we initially describe the importance of considering the efficacy of corticosteroid therapy based not only on short‐term outcomes, but also on long‐term outcomes of a certain type of severe drug eruption, drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS). Our view is exemplified by our recent analysis of previously reported cases of DiHS/DRESS, revealing that aggressive treatment such as pulsed corticosteroids and intravenous immunoglobulin, although beneficial in the short term, paradoxically has deleterious effects such as autoimmune sequelae in the long term. Thus, measuring the therapeutic efficacy from only a short‐term perspective is insufficient and follow‐up examination of these patients for at least three years is required even after complete resolution is observed. Various cutaneous diseases refractory to conventional therapies that occur after resolution of herpes zoster also require a temporal perspective to understand how cutaneous diseases develop at a certain site. We describe the clinical usefulness of considering the dual actions of corticosteroids, antiinflammatory, and immunostimulatory, depending on the situations in which they are used.
On the Role of Ferromagnetic Interactions in Highly Active Mo‐Based Catalysts for Ammonia Synthesis
Authors: Munarriz Julen , Polo Victor , Gracia Jose 
Published: August 2018

AbstractReactions involving nitrogen fixation and transfer are of great industrial interest. In this regard, unveiling all the physical principles that determine their activity would be enormously beneficial for the rational design of novel catalysts with improved performance. Within this context, this work explores the activity of bulk molybdenum‐based transition metal nitrides in ammonia synthesis. Our results highlight that the most active compositions show increasing ferromagnetism in the metal–nitrogen bonds, which constitute the active sites. We observe that the total spin accumulated in the bonds at the active sites is a physically meaningful descriptor to discriminate optimum catalysts. Higher activities are associated with ferromagnetic phases, and the underlying reason is an enhanced overlapping of the electronic wavefunctions; which also make the reaction steps spin‐sensitive. These finding provides strong evidence of the general influence of electrons magnetic moment in catalysis, being part of the specific field of spintro‐catalysis.
Tuning Cobalt and Nitrogen Co‐Doped Carbon to Maximize Catalytic Sites on a Superabsorbent Resin for Efficient Oxygen Reduction
Authors: Liu Mengran , Lin Hai , Mei Zongwei , Yang Jinlong , Lin Jie , Liu Yidong , Pan Feng 
Published: August 2018

AbstractThe electrocatalytic performance and cost of oxygen reduction reaction (ORR) catalysts are crucial to many renewable energy conversion and storage systems/devices. Recently, transition‐metal/nitrogen‐doping carbon catalysts (M–N–C) have attracted tremendous attention due to their low cost and excellent catalytic activities; however, they are restricted in large‐scale commercial applications by complex preparation processing. Here, a facile strategy to prepare Co–N–C catalysts has been developed. A kind of superabsorbent resin normally found in diapers, poly(acrylic acid‐acrylamide), is used to adsorb a transition‐metal cobalt salt and a pyrolysis strategy at 800 °C under an argon atmosphere is followed. The resin simultaneously plays a multiple role, which includes structural support, dispersing cobalt ions by coordinate bonds, and providing a carbon and nitrogen source. Attributed to the conductive carbon frameworks and abundant catalytic sites, the Co–N–C catalyst exhibits an excellent electrocatalytic performance. High onset potential (0.96 V vs. reversible hydrogen electrode, RHE), half‐wave potential (0.80 V vs. RHE), and a large diffusion‐limited current density (4.65 mA cm−2) are achieved for the ORR, which are comparable or superior to the commercial 20 % Pt/C and reported M–N–C ORR electrocatalysts. This work provides a universal dispersion technology for Co–N–C catalyst, which makes it a very promising candidate toward the ORR.
Development of a Novel FIJI‐Based Method to Investigate Neuronal Circuitry in Neonatal Mice
Authors: Mei‐ling Liu Jillian , Fair Summer Rose , Kaya Behiye , Zuniga Jessica Nabile , Mostafa Hasnaa Rashad , Alves Michele Joana , Stephens Julie A. , Jones Mikayla , Aslan M. Tahir , Czeisler Catherine , Otero José Javier 
Published: August 2018

AbstractThe emergence of systems neuroscience tools requires parallel generation of objective analytical workflows for experimental neuropathology. We developed an objective analytical workflow that we used to determine how specific autonomic neural lineages change during postnatal development. While a wealth of knowledge exists regarding postnatal alterations in respiratory neural function, how these neural circuits change and develop in the weeks following birth remains less clear. In this study, we developed our workflow by combining genetic mouse modeling and quantitative immunofluorescent confocal microscopy and used this to examine the postnatal development of neural circuits derived from the transcription factors NKX2.2 and OLIG3 into three medullary respiratory nuclei. Our automated FIJI‐based image analysis workflow rapidly and objectively quantified synaptic puncta in user‐defined anatomic regions. Using our objective workflow, we found that the density and estimated total number of Nkx2.2‐derived afferents into the pre‐Bötzinger Complex significantly decreased with postnatal age during the first three weeks of postnatal life. These data indicate that Nkx2.2‐derived structures differentially influence pre‐Bötzinger Complex respiratory oscillations at different stages of postnatal development.
Co/Co‐N@Nanoporous Carbon Derived from ZIF‐67: A Highly Sensitive and Selective Electrochemical Dopamine Sensor
Authors: Srinivas Chandrasekaran , Sudharsan Murugesan , Reddy G. Rajendra Kumar , Kumar P. Suresh , Amali Arlin Jose , Suresh D. 
Published: August 2018

AbstractCo/Co‐N nanoparticles incorporated nitrogen‐doped nanoporous carbon (Co/Co‐N@NPC) nanostructures were fabricated via pyrolysis of metal organic framework, ZIF‐67, under argon atmosphere. The ZIF‐67 derived Co/Co‐N@NPC modified carbon paste electrode exhibited excellent performance during electroanalysis of dopamine, displaying two linear ranges; 10 nM to 50 μM, and 50 μM–500 μM with sensitivity of 12.4±0.3 μA/μM/cm2 and11.69±0.06 μA/μM/cm2, respectively. The modified electrodes were observed to be highly selective towards dopamine even in presence of other interfering biomolecules such as ascorbic acid, glucose and uric acid. To the best of our knowledge, the sensing ability of Co/Co‐N@NPC with a lower limit of detection as 6 nM is the best compared to the previously reported cobalt mediated sensors for dopamine. Practical feasibility of the sensor was demonstrated in real sample analysis of dopamine measurement in human urine samples and dopamine hydrochloride injection samples.
Simultaneous Determination of Antioxidants in Edible Oils Using Graphene Oxide/β‐Cyclodextrin‐modified Electrochemical Sensor
Authors: Shi Zhaoxia , Tan Jie , Hu Yufei , Li Gongke , Xiao Xiaohua 
Published: August 2018

AbstractIn this work, graphene oxide/β‐cyclodextrin (GO/β‐CD) composite was synthesised and applied to construct a highly sensitive electrochemical sensor for the determination of propyl gallate (PG) and butyl hydroxy anisole (BHA) in edible oil, simultaneously. Various methods were used to characterize the properties of GO/β‐cyclodextrin composite. Furthermore, the oxidation peak currents of PG and BHA were increased obviously at the modified glassy carbon electrode, which improved the sensitivity of proposed method. Under optimal conditions, the peak currents of PG and BHA increased linearly with its concentration in the range of 0.1–30.0 μmol/L and 0.05–30 μmol/L, respectively. The limit of detections were as low as 0.01 μmol/L and 0.03 μmol/L, respectively. Finally, the sensor was successfully applied to edible oil sample analysis. The recoveries varied from 95.3 % to 108.6 % with the RSDs 2.9 %–4.9 %, indicated that the proposed sensor can be used for the simultaneous determination of PG and BHA in edible oil.
The effect of different emotional states on olfactory perception: A preliminary study
Authors: Hamakawa Masayuki , Okamoto Tsuyoshi 
Published: August 2018

AbstractEmotion evoked by odours can be determined or modulated by several factors, including odorant–receptor interactions and olfactory experiences. As a result of these factors, some odours can induce an emotional discrepancy, such as a conflict between innately determined and experience‐based emotions. This study examined whether the difference between two subjective ratings, pleasantness and liking, for an odour can influence olfactory perception, and explored whether the emotional discrepancy had any effect on olfaction. We conducted a psychophysical experiment wherein 12 participants (six women and six men, mean age = 22.0 years) evaluated 36 odours. Participants were instructed to evaluate each odorant in terms of four qualities: (i) pleasantness, (ii) liking, (iii) olfactory perceptual descriptors, and (iv) odour intensity. Participants were also asked to note the difference between pleasantness and liking, whereby the former referred to instinctive and innate feelings and the latter to experience‐based and acquired feelings. Ten odorants exhibited a discrepancy between pleasantness and liking ratings. Another 10 odorants exhibited a significant relationship between the choice of perceptual descriptors and intensity; this was not true of the 10 discrepant odorants. This preliminary study showed that differences in pleasantness and liking ratings can affect the selection of olfactory descriptors, according to odour intensity. The findings suggest that olfactory lexical semantic representations could be confused by discrepant odour‐evoked emotions.
Mortality effects of economic fluctuations in selected eurozone countries
Authors: Seklecka Malgorzata , Md. Lazam Norazliani , Pantelous Athanasios A. , O'Hare Colin 
Published: August 2018

AbstractSocioeconomic status is commonly conceptualized as the social standing or well‐being of an individual or society. Higher socioeconomic status has long been identified as a contributing factor for mortality improvement. This paper studies the impact of macroeconomic fluctuations (having gross domestic product (GDP) as a proxy) on mortality for the nine most populous eurozone countries. Based on the statistical analysis between the time‐dependent indicator of the Lee and Carter (Journal of the American Statistical Association, 1992, 87(419), 659–671) model and GDP, and adaptation of the good features of the O'Hare and Li (Insurance: Mathematics and Economics, 2012, 50, 12–25) model, a new mortality model including this additional economic‐related factor is proposed. Results for male and female from ages between 0 and 89, and similar for unisex data, are provided. This new model shows a better fitting and more plausible forecast among a significant number of eurozone countries. An in‐depth analysis of our findings is provided to give a better understanding of the relationship between mortality and GDP fluctuations.
Learning dynamics in the formation of European inflation expectations
Authors: Bräuning Christina , van der Cruijsen Carin 
Published: August 2018

AbstractWe investigate learning dynamics in the formation of household inflation expectations in the six largest euro area countries. Our findings reveal heterogeneity in the learning rules that European households use to forecast inflation. We also find pronounced heterogeneity in the way consumers process new data. These differences vary not only across countries but also over time, suggesting that the learning behavior of households is state dependent.
Objective PET study of glucose metabolism asymmetries in children with epilepsy: Implications for normal brain development
Authors: Pilli Vinod K. , Jeong Jeong‐Won , Konka Praneetha , Kumar Ajay , Chugani Harry T. , Juhász Csaba 
Published: August 2018

AbstractClinical interpretation of cerebral positron emission tomography with 2‐deoxy‐2[F‐18]fluoro‐d‐glucose (FDG‐PET) images often relies on evaluation of regional asymmetries. This study was designed to establish age‐related variations in regional cortical glucose metabolism asymmetries in the developing human brain. FDG‐PET scans of 58 children (age: 1–18 years) were selected from a large single‐center pediatric PET database. All children had a history of epilepsy, normal MRI, and normal pattern of glucose metabolism on visual evaluation. PET images were analyzed objectively by statistical parametric mapping with the use of age‐specific FDG‐PET templates. Regional FDG uptake was measured in 35 cortical regions in both hemispheres using an automated anatomical labeling atlas, and left/right ratios were correlated with age, gender, and epilepsy variables. Cortical glucose metabolism was mostly symmetric in young children and became increasingly asymmetric in older subjects. Specifically, several frontal cortical regions showed an age‐related increase of left > right asymmetries (mean: up to 10%), while right > left asymmetries emerged in posterior cortex (including portions of the occipital, parietal, and temporal lobe) in older children (up to 9%). Similar trends were seen in a subgroup of 39 children with known right‐handedness. Age‐related correlations of regional metabolic asymmetries showed no robust gender differences and were not affected by epilepsy variables. These data demonstrate a region‐specific emergence of cortical metabolic asymmetries between age 1–18 years, with left > right asymmetry in frontal and right > left asymmetry in posterior regions. The findings can facilitate correct interpretation of cortical regional asymmetries on pediatric FDG‐PET images across a wide age range.
The approximate solution of finite‐horizon discrete‐choice dynamic programming models
Authors: Eisenhauer Philipp 
Published: August 2018

SummaryThe estimation of finite‐horizon discrete‐choice dynamic programming (DCDP) models is computationally expensive. This limits their realism and impedes verification and validation efforts. Keane and Wolpin (Review of Economics and Statistics, 1994, 76(4), 648–672) propose an interpolation method that ameliorates the computational burden but introduces approximation error. I describe their approach in detail, successfully recompute their original quality diagnostics, and provide some additional insights that underscore the trade‐off between computation time and the accuracy of estimation results.