bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived roles of independent community pharmacists and pharmacy technicians in patient referrals to community resources: A Study from the Medication Safety Research Network of Indiana (Rx‐SafeNet)
Authors: Miller Rebecca G. , Perras Cassie A. , Frail Caitlin K. , Adeoye Omolola A. , Snyder Margie E. 
Published: June 2019

AbstractIntroductionReferrals to community resources represent one element of the Chronic Care Model, however, little is known about the perceived role of community pharmacy staff in referring patients to community resources.ObjectivesThe objective of this study was to describe community pharmacists', community pharmacy technicians', and patients' perceptions of pharmacist referrals to community resources.MethodsSemi‐structured interviews were conducted with community pharmacists, pharmacy technicians, and patients from community pharmacies that are members of the Medication Safety Research Network of Indiana. Qualitative analysis was conducted to identify emergent themes.ResultsA total of 37 participants, including six community pharmacists, one pharmacy student completing an advanced pharmacy practice experience, 15 community pharmacy technicians, and 15 patients across four independently owned community pharmacies were interviewed. Themes included: (1) Need to build on a foundation of strong patient‐community pharmacist relationships to clearly define the pharmacist's role in referrals, (2) Need to improve familiarity with community resources, (3) Need to clearly delineate and support the role for pharmacy technicians in making referrals, and (4) Need to follow‐up on referrals.ConclusionTo enhance community pharmacy staff provision of referrals to community resources, interventions are needed to improve patient and pharmacist familiarity with available resources, patients' perception of the pharmacist's role outside of prescription fulfillment, and follow‐up on referrals. Moreover, pharmacy technician education and training could be expanded to optimize their role in supporting community pharmacists in making referrals.
Impact of a pharmacy‐cardiology collaborative management program during initiation of antiarrhythmic drugs
Authors: Kibert Jeffery L. , Franck Jessica Bovio , Dietrich Nicole Maltese , Quffa Lieth H. , Franck Andrew J. 
Published: June 2019

AbstractObjectiveAntiarrhythmic drugs (AADs) are commonly used for management of atrial fibrillation and other cardiac arrhythmias. However, the use of AADs in clinical practice is challenging due to the risk of serious adverse drug events associated with these medications. Adherence to recommended monitoring parameters may improve safety in these agents. The primary objective of this study was to determine the effectiveness of a pharmacy‐cardiology collaborative approach to AAD management.MethodsThis retrospective cohort study was conducted to assess AAD management with a pharmacy‐cardiology collaborative program compared with usual care in a United States Department of Veterans Affairs (VA) medical center.ResultsNinety patients were included for evaluation; 40 in the preintervention group and 50 in the postintervention group. Complete recommended baseline monitoring parameters were obtained for 29 patients (72.5%) in the preintervention group and 47 patients (94%) in the postintervention group (P < .01). There were significantly more clinical interventions (P < .01) in the postintervention group, including AAD dose adjustment or discontinuation, interacting medication dose adjustment or discontinuation, electrolyte supplementation, monitoring ordered, and total interventions.ConclusionThe study results demonstrate a statistically significant improvement in adherence to recommended baseline monitoring parameters with a greater number of clinical interventions when a pharmacy‐cardiology collaborative AAD management program was involved compared with usual care. The increased interventions and improved adherence to monitoring parameters may allow for safer use of these agents.
Bowman's topography for improved detection of early ectasia
Authors: Chandapura Rachana , Salomão Marcella Q. , Ambrósio Renato , Swarup Rishi , Shetty Rohit , Sinha Roy Abhijit 
Published: June 2019

AbstractThe aim of this study was to evaluate whether OCT topography of the Bowman's layer and artificial intelligence (AI) can result in better diagnosis of forme fruste (FFKC) and clinical keratoconus (KC). Normal (n = 221), FFKC (n = 72) and KC (n = 116) corneas were included. Some of the FFKC and KC patients had the fellow eye (VAE‐NT) with normal topography (n = 30). The Scheimpflug and OCT scans of the cornea were analyzed. The curvature and surface aberrations (ray tracing) of the anterior corneal surface [air‐epithelium (A‐E) interface in OCT] and epithelium‐Bowman's layer (E‐B) interface (in OCT only) were calculated. Four random forest models were constructed: (1) Scheimpflug only; (2) OCT A‐E only; (3) OCT E‐B only; (4) OCT A‐E and E‐B combined. For normal eyes, both Scheimpflug and OCT (A‐E and E‐B combined) performed equally in identifying these eyes (P = .23). However, OCT A‐E and E‐B showed that most VAE‐NT eyes were topographically similar to normal eyes and did not warrant a separate classification based on topography alone. For identifying FFKC eyes, OCT A‐E and E‐B combined performed significantly better than Scheimpflug (P = .006). For KC eyes, both Scheimpflug and OCT performed equally (P = 1.0). Thus, OCT Topography of Bowman's layer significantly improved the detection of FFKC eyes.
Correlations of severity of asthma in children with body mass index, adiponectin and leptin
Authors: Ma Chunli , Wang Yujun , Xue Man 
Published: June 2019

AbstractBackgroundThis study aims to investigate the correlations of asthma in children with body mass index (BMI), adiponectin, and leptin.MethodsA total of 122 children with asthma in our hospital from January 2017 to February 2018 were randomly selected and divided into control group (normal) and observation group (BMI > 28 kg/m2) according to BMI. BMI, adiponectin, and leptin levels between the two groups were measured and compared, and correlations of disease grade with BMI, adiponectin, or leptin were analyzed. Moreover, risk factors for asthma in children were also identified.ResultsBody mass index, leptin level, forced vital capacity (FVC), FVC%, and forced expiratory volume in 1s (FEV1)/FVC in observation group were significantly higher than those in control group (P < 0.05), while the adiponectin level, forced expiratory capacity in 1s (FEC1), and FEV1% in observation group were significantly lower than those in control group (P < 0.05). The amount of severe patients in observation group was much larger than that in control group. The severity of disease was positively correlated with BMI and leptin and negatively correlated with adiponectin. BMI, adiponectin, and leptin were identified as risk factors for asthma in children.ConclusionAdiponectin, leptin, and BMI are involved in the pathogenesis of asthma in children, suggesting they might be therapeutic targets for clinical treatment.
Prognostic value of the tumor‐specific ceRNA network in epithelial ovarian cancer
Authors: Li Gailing , Han Liping , Ren Fang , Zhang Ruitao , Qin Guijun 
Published: June 2019

AbstractEpithelial ovarian cancer is one of the leading causes of cancer‐related death worldwide. Growing evidence indicates that multiple complex altered pathways play important regulatory roles in the development and progression of a variety of cancers, including epithelial ovarian cancer. However, the underlying mechanisms remain unclear. First, we identified differentially expressed messenger RNAs (mRNAs), long noncoding RNAs (lncRNAs), and microRNAs (miRNAs) in epithelial ovarian cancer by comparing the expression profiles between epithelial ovarian cancer samples and normal tissue samples in different GEO datasets. Then, GO‐ and KEGG‐pathway‐enrichment analyses were applied to investigate the primary functions of the overlapped differentially expressed mRNAs. Moreover, the primary enriched genes were used to construct the signal‐network with Cytoscape software. In addition, we integrated the relationship among lncRNAs‐miRNAs‐mRNAs to create a competing endogenous RNA network. Finally, mRNAs that were associated with patient prognosis in epithelial ovarian cancer were selected using univariate Cox regression analysis. A total of 2,225 mRNAs, 336 lncRNAs, and 14 miRNAs were shown to be differentially expressed in epithelial ovarian cancer compared with normal tissues. The dysregulated mRNAs were primarily enriched in cell division and signal transduction, according to Gene Ontology, whereas, according to KEGG, they were primarily enriched in metabolic pathways and pathways in cancer. A total of 10 mRNAs were associated with patient prognosis in ovarian cancer. This study identifies a novel lncRNA–miRNA–mRNA network, which may suggest potential molecular mechanisms underlying the development of epithelial ovarian cancer, providing new insights for survival prediction and interventional strategies for epithelial ovarian cancer.
Retracted: Chemoresistance in gastric cancer is attributed to the overexpression of excision repair cross‐complementing 1 (ERCC1) caused by microRNA‐122 dysregulation
Authors: Song Ai‐Ling , Zhao Lei , Wang Yan‐Wei , He Dong‐Qiang , Li Yu‐Min 
Published: June 2019

AbstractMicroRNAs are deemed as key regulators of gene expression. In particular, the elevated expression of excision repair cross‐complementing 1 (ERCC1) significantly reduced the effectiveness of gastric cancer treatment by cisplatin (CDDP)‐based therapies. In this paper, qRT‐PCR and western blot were adopted to measure miR‐122 and ERCC1 messenger RNA (mRNA) expression in all samples. Luciferase assay was carried out to verify the role of ERCC1 as a target of miR‐122. The CCK‐8 assay was carried out to study the effect of ERCC1 and miR‐122 on cell survival and apoptosis. The results demonstrated that miR‐122 expression was reduced in cisplatin‐resistant gastric cancer. Using bioinformatic analysis, miR‐122 was shown to target the 3′‐UTR of human ERCC1. A dual‐luciferase assay demonstrated that miR‐122 downregulated ERCC1 expression, while the mutations in ERCC1 3′‐UTR abolished its interaction with miR‐122. Transfection of miR‐122 mimics decreased the levels of ERCC1 mRNA and protein expression, while the transfection of miR‐122 inhibitors increased the levels of both ERCC1 mRNA and protein expression. Furthermore, we found that overexpressed miR‐122 promoted the proliferation of MKN74 cells and reduced their apoptotic by targeting ERCC1. In addition, the levels of miR‐122 and ERCC1 were negatively correlated in gastric cancer samples. In summary, the reduced miR‐122 expression may play an essential role in the induction of cisplatin‐resistance by increasing ERCC1 expression.
MicroRNA‐200c promotes osteogenic differentiation of human bone mesenchymal stem cells through activating the AKT/β‐Catenin signaling pathway via downregulating Myd88
Authors: Xia Peng , Gu Rui , Zhang Wei , Shao Liwei , Li Fang , Wu Changyan , Sun Yifu 
Published: June 2019

AbstractDuring the human bone formation, the event of osteogenic differentiation of human bone mesenchymal stem cells (hBMSCs) is vital, and recent evidence has emphasized the important role of microRNAs (miRNAs) in osteogenic differentiation of hBMSCs. This study aims to examine the potential effects of miR‐200c in osteogenic differentiation of hBMSCs and understand their underlying mechanisms. HBMSCs were obtained via human bone marrow. During osteogenic induction and differentiation, cells were transfected with different plasmids with the intention of investigating the roles of miR‐200c on osteogenic differentiation, calcium salt deposition, alkaline‐phosphatase (ALP) activity, mineralized nodule formation, osteocalcin (OCN) content, and proliferation of osteoblasts. Following transfection, dual luciferase reporter gene assay was conducted so as to explore the correlation between miR‐200c and Myd88. Moreover, the AKT/β‐Catenin signaling pathway was blocked with an AKT/β‐Catenin inhibitor, AKTi, to investigate its involvement. The hBMSCs were successfully isolated from human bone marrow. Myd88 was determined as a target gene of miR‐200c. Gain and loss‐of‐function assays confirmed that overexpression of miR‐200c, or silencing of Myd88 promoted osteogenic differentiation, increased calcium salt deposition, ALP activity, mineralized nodule formation, and enhanced the proliferation of osteoblasts following osteogenic differentiation of hBMSCs. Meanwhile, the downregulation of miR‐200c has been shown to have the opposite effect. Furthermore, these findings showed that the miR‐200c overexpression activated the AKT/β‐Catenin signaling pathway by targeting Myd88. To sum up, the miR‐200c upregulation induces osteogenic differentiation of hBMSCs by activating the AKT/β‐Catenin signaling pathway via the inhibition of Myd88, providing a target for treatment of bone repair.
Cx32 mediates norepinephrine‐promoted EGFR‐TKI resistance in a gap junction‐independent manner in non‐small‐cell lung cancer
Authors: Xie Jie , Wang Xiyan , Ge Hui , Peng Fuhua , Zheng Ningze , Wang Qin , Tao Liang 
Published: June 2019

AbstractThe second‐generation EGFR‐TKI Afatinib is an irreversible ErbB family blocker used to treat patients with non‐small‐cell lung cancer (NSCLC). Unfortunately, resistance to this drug develops over time, and patients are always under great psychological pressure. A previous study showed that chronic stress hormones participate in EGFR‐TKI resistance via β2‐AR signaling via an IL‐6 dependent mechanism. Our study further explores a novel potential underlying mechanism. In the present study, we show that the stress hormone norepinephrine (NE) promotes Afatinib resistance by upregulating Cx32 expression. Furthermore, we, for the first time, find that Cx32 is a target gene for transcription factor CREB and NE enhances Cx32 mRNA expression by activation of CREB. We also demonstrate that Cx32 promotes Afatinib resistance by decreasing the degradation of EGFR‐TKI resistance‐associated proteins (MET, IGF‐1R) and by increasing their transcription levels. Together, these results reveal that the stress hormone NE accelerates Afatinib resistance by increasing the expression of Cx32, which augments MET and IGF‐1R levels in cancer cells and provides a promising therapeutic strategy against EGFR‐TKI Afatinib resistance in NSCLC.
Removing NOx, CO and HC from automobile exhaust based on chemical looping combustion
Authors: Wu Yongjian , Luo Chunhuan , Wu Wei , Su Qingquan 
Published: June 2019

AbstractBackgroundTo meet more stringent automobile exhaust emission standards without using platinum group metal three‐way catalysts (TWCs), two nonprecious metal oxide oxygen carriers, Cu10/Al90 and Ni10/Al90, were investigated for the simultaneous and thorough removal of nitrogen oxides (NOx), carbon monoxide (CO) and hydrocarbons (HC) from automobile exhaust.ResultsIn oxidation reactions of the reductive oxygen carriers with NO, the reductive oxygen carriers were converted to the oxidative oxygen carriers and NO was simultaneously reduced to N2. Then, the oxidative oxygen carriers were regenerated to the reductive oxygen carriers with reducing gases, including CO, H2 and HC. At the same time, CO was converted to CO2, H2 was converted to H2O, and HC was converted to CO2 and H2O. The simultaneous removal of NOx, CO and HC could be achieved based on a chemical looping combustion mechanism. Compared with Ni10/Al90, Cu10/Al90 exhibited better performance for removing NO, CO and C3H6 from simulated automobile exhaust. However, the reductive Ni10/Al90 had an excellent steam reforming catalytic activity and was capable of converting residual C3H6 in the exhaust to harmless H2 and CO2.ConclusionBased on these findings, a novel chemical looping combustion process is proposed, in which the first oxygen carrier‐filling layer based on Cu10/Al90 removed NOx, CO and HC simultaneously, and the second oxygen carrier‐filling layer based on Ni10/Al90 removed residual NO and C3H6. © 2019 Society of Chemical Industry
Filling the complexity gaps for colouring planar and bounded degree graphs
Authors: Dabrowski Konrad K. , Dross François , Johnson Matthew , Paulusma Daniël 
Published: June 2019

AbstractA colouring of a graph is a function such that for every . A ‐regular list assignment of is a function with domain such that for every , is a subset of of size . A colouring of respects a ‐regular list assignment of if for every . A graph is ‐choosable if for every ‐regular list assignment of , there exists a colouring of that respects . We may also ask if for a given ‐regular list assignment of a given graph , there exists a colouring of that respects . This yields the ‐Regular List Colouring problem. For , we determine a family of classes of planar graphs, such that either ‐Regular List Colouring is ‐complete for instances with , or every is ‐choosable. By using known examples of non‐‐choosable and non‐‐choosable graphs, this enables us to classify the complexity of ‐Regular List Colouring restricted to planar graphs, planar bipartite graphs, planar triangle‐free graphs, and planar graphs with no ‐cycles and no ‐cycles. We also classify the complexity of ‐Regular List Colouring and a number of related colouring problems for graphs with bounded maximum degree.
Effect of Enhanced Recovery After Surgery program on pancreaticoduodenectomy: a randomized controlled trial
Authors: Hwang Dae Wook , Kim Hwa Jung , Lee Jae Hoon , Song Ki Byung , Kim Myeong‐Hwan , Lee Sung Koo , Choi Kyu Taek , Jun In‐Gu , Bang Ji‐Yeon , Kim Song Cheol 
Published: June 2019

AbstractBackgroundThis study aims to investigate the noninferiority of Enhanced Recovery After Surgery (ERAS) for pancreaticoduodenectomy (PD).MethodsIn this single‐center trial, we randomly assigned 276 adult patients who underwent open PD into ERAS and conventional groups with 138 patients in each, from 2015 through 2017. The primary endpoint was the incidence of overall morbidity until postoperative 3 months. The secondary endpoints were in‐hospital or 30‐day mortality, postoperative length of stay (LOS), nutritional status and overall hospital costs.ResultsOverall morbidity was reported in 64 patients (52.0%, ERAS group) and in 68 patients (54.8%, conventional group) (risk difference [RD] −2.81 percentage points (pp); 90% two‐sided confidence interval −13.24 to 7.63). Mortality did not occur in any patients. The two groups did not differ significantly in median postoperative LOS (both 11 days; RD −8.46 pp), body mass index (22.4 ± 2.75 vs. 22.4 ± 2.65 kg/m2; RD −3.48 pp), Patient‐Generated Subjective Global Assessment score over 4 (45 [40.5%] vs. 50 [43.1%] patients; RD −2.56 pp), and median overall hospital cost (15.61 vs. 16.04, ×106 KRW; RD −6.08 pp).ConclusionsEven in PD, modified ERAS protocol was not inferior to conventional protocol, while reducing treatment burden.
Relationship between the ablation index, lesion formation, and incidence of steam pops
Authors: Mori Hitoshi , Kato Ritsushi , Sumitomo Naokata , Ikeda Yoshifumi , Goto Koji , Tanaka Sayaka , Asano So , Tahara Mai , Nagase Takahiko , Iwanaga Shiro , Muramatsu Toshihiro , Matsumoto Kazuo 
Published: June 2019

AbstractBackgroundThe ablation index (AI) is reported to be useful for a durable pulmonary vein isolation (PVI). However, there have been no studies investigating the relationship between the power, contact force (CF), AI, and steam pops.MethodsUsing an in vitro model, ablation energy was delivered until a steam pop occurred and the time to the steam pop and AI when the steam pop occurred were measured. The experiment was performed with a combination of various powers (20, 30, 40, and 50 W) and contact forces (CFs) (10, 30, and 50 g) 20 times for each setting. The analysis consisted of two protocols. The first protocol was a comparison between the ablation power and several parameters under the same CF (10, 30, and 50 g). The second protocol was a comparison between the CF and several parameters under the same power (20, 30, 40, and 50 W). The correlation between the lesion formation and ablation parameters was evaluated.ResultsThe AI value when steam pops occurred varied depending on the ablation settings. All AI median values were <500 under an ablation power of 50 W. On other hand, the median ablation time up to the steam pop was more than 46 seconds, but all median values of the AI were more than 550 under an ablation with 20 W.ConclusionsThe AI cannot predict steam pops. A low power and long duration ablation could obtain a high AI value. However, high‐power ablation could not obtain a high AI value because of an early occurrence of steam pops.
The SAFRAN daily gridded precipitation product in Tunisia (1979–2015)
Authors: Tramblay Yves , Feki Haifa , Quintana‐Seguí Pere , Guijarro José A. 
Published: June 2019

AbstractA new high‐resolution (5 km) gridded daily precipitation dataset for Tunisia between 1979 and 2015 is introduced. This product combines 960 rain gauges with the SAFRAN analysis to produce the precipitation gridded data. A validation approach on two different datasets reveals that the SAFRAN analysis outperforms other standard interpolation methods such as Inverse Distance, Nearest Neighbors, Ordinary Kriging or Residual Kriging with altitude. When compared to EOBS, a widely used gridded dataset over Europe, a strong negative bias in EOBS precipitation is found. However due to the aridity and the low density of rain gauges in south Tunisia, results in this region must be analyzed with care. The SAFRAN product could be useful for various purposes such as climate model evaluation, climate studies, hydrological modelling to support the planning and management of surface water resources in Tunisia.
Change in the spatiotemporal pattern of snowfall during the cold season under climate change in a snow‐dominated region of China
Authors: Bai Lei , Shi Chunxiang , Shi Qingdong , Li Lanhai , Wu Jing , Yang Yanfen , Sun Shuai , Zhang Feiyun , Meng Junyao 
Published: June 2019

AbstractThe spatiotemporal pattern of precipitation is significantly changing with global climate change. Snowfall is a solid phase of precipitation and an important water resource. With two gridded data sets of APHRO (Asia Precipitation‐Highly‐Resolved Observational Data Integration Towards Evaluation of Water Resources) and CN05.1, this study analyses the changes in the spatiotemporal pattern of snowfall in a snow‐dominant region of China from 1961 to 2015. The results indicate the significant increasing trend of winter snowfall in horizontal and altitude dimension in snow‐dominant regions, but the winter snowing season length shortened. For the frequency of snowfall intensity level, light, and heavy snowfall and snowstorms increased, but moderate snowfall showed no change. However, the intensity of extreme snowfall in once‐in‐a‐century was decreasing in all of the snow‐dominant regions. In the altitude dimension, the increasing trend in snow‐dominant conditions was not uniform, which may be related to change in air temperature and water vapour through the vertical atmospheric levels. The upwards trend in snowfall may be caused by the increase of atmospheric water content rather than the change of snowy weather conditions. In addition, the change values of climate indices can also contribute to snowfall increasing in snow‐dominant regions.