bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ghending Dangdut: Artikulasi Budaya Masyarakat Madura dalam Seni Tabbhuwan
Authors: Hidayatullah Panakajaya 
Published: September 2019

Tulisan ini merupakan hasil dari penelitian antropologi musik dengan metode etnografi yang menelaah tentang artikulasi budaya masyarakat Madura melalui ghendhing dangdut dalam seni tabbhuwân Madura. Sorotan dalam penelitian ini adalah perihal hubungan musik dan masyarakat: bagaimana masyarakat Madura memaknai budayanya melalui seni tabbhuwân, dan bagaimana mereka mengekspresikannya. Secara khusus akan membaca bentuk ekspresi simboliknya melalui analisis musikologis bentuk-bentuk musikal garap dangdut pada tabbhuwân Madura. Melalui analisis musikologis, akan dilihat pola-pola, kaidah dan kecenderungan musikal yang digunakan oleh masyarakat Madura dan nantinya akan dikomparasikan dengan pola-pola garap dangdut pada gamelan Jawa. Penelitian ini menggunakan pendekatan multidisipliner yang mewacanakan teori musikologi dengan antropologi budaya. Temuan penelitian ini adalah 1) Berdasarkan analisis musikologis, dapat dikatakan bahwa ghendhing dangdut dalam budaya Madura bersifat lebih luwes, longgar dan dinamis dibanding dengan budaya Jawa. Hal ini menunjukkan bahwa masyarakat Madura merupakan masyarakat yang dinamis, inklusif, ulet, tegas dan adaptatif. Mereka juga mampu merespon perubahan jaman, mempertanyakan kemapanan modernitas dan ke’adiluhung’-an budaya; 2) Bentuk tabbhuwân yang dinamis adalah cara masyarakat Madura memaknai budaya dan realitas hari ini (kontemporer). Tabbhuwân merupakan wujud interaksi budaya Madura dengan budaya lain, pemaknaan atas modernitas serta wujud konservasi budaya lokal.
Prevenir Complicações: Linfadenectomia Inguinal Modificada Vídeo-Assistida no Estadiamento do Tumor do Pénis
Authors: Pereira-Lourenço Mário , Vieira-Brito Duarte , Godinho Ricardo , Peralta Pedro , Conceição Paulo , Rabaça Carlos , Reis Mário , Sismeiro Amílcar 
Published: September 2019

A linfadenectomia inguinal modificada permite um estadiamento correto na maioria dos casos de carcinoma do pénis sem gânglios inguinais palpáveis. Atualmente, é possível reproduzir a técnica cirúrgica clássica por via vídeo-assistida, com resultados oncológicos semelhantes e menor taxa de complicações.
O artigo reporta um caso de tumor do pénis, sujeito a penectomia total (pT3NxMx), sem gânglios inguinais palpáveis, onde se realizou uma linfadenectomia inguinal modificada vídeo-assistida (LIMVA) bilateral, sendo descrita a técnica cirúrgica da LIMVA direita.
Neste artigo são descritos todos os passos da técnica cirúrgica (posicionamento do doente, disseção romba profundamente à faixa de Scarpa, identificação dos limites anatómicos da disseção, identificação dos vasos femorais, identificação da veia safena até a fossa ovalis, excisão dos gânglios e encerramento).
A grande vantagem da LIMVA é a diminuição de complicações pós-operatórias, nomeadamente a baixa taxa de deiscência da ferida operatória e de edema dos membros inferiores.
Percutaneous or Transurethral Cystolithotomy for Bladder Lithiasis: Which is Safer?
Authors: Torres Joao Pimentel , Fernandes Vítor , Morais Nuno , Anacleto Sara , Mota Paulo , Lima Estêvão 
Published: September 2019

Introduction: Although the risk of urethral trauma while treating bladder stones is worrisome, evidence about the best treatment approach is scarce. The aim of this study is to compare the safety and efficacy of transurethral cystolithotomy and percutaneous suprapubic cystolithotomy in adults´ bladder lithiasis treatment.
Methods: We retrospectively evaluated 120 patients (January 2012 to December 2017) who were surgically treated for bladder lithiasis with percutaneous suprapubic cystolithotomy (n= 20) and transurethral cystolithotomy (n= 100). Age, gender, calculi size, surgery duration, hospital stay, post-operative infections, haematuria, pain and urethral strictures were evaluated. Previous diagnosis of benign prostate hyperplasia and urethral strictures were also considered.
Results: Both groups were homogeneous according to the pre-operative variables evaluated, including calculi dimensions and simultaneous diagnosis. Median surgery time in percutaneous suprapubic cystolithotomy and transurethral cystolithotomy were 65 and 58 minutes, respectively (p= 0.043). Pain and haematuria were similar in both groups. Median hospital stay was 2.0 days in both groups. Median follow-up time was 13 months. In the transurethral cystolithotomy, three patients (3%) developed urethral stricture while none of the patients treated with PSC developed urethral strictures during the follow-up (p= 0.435).
Discussion: Percutaneous suprapubic cystolithotomy theoretically offers an advantage over transurethral cystolithotomy in terms of urethral trauma, although we did not observe a significant difference. However, it deserves to be considered, especially in patients with known urethral strictures that may hinder transurethral access. Further prospective studies with more patients may however confirm these theoretical advantages.
Válvulas da Uretra Posterior: Experiência de um Hospital Nível III
Authors: Almeida Sónia , Cascais Mafalda , Cordinha Carolina , Do Carmo Carmen , Gomes Clara , Coutinho Sílvia , Ramos Manuel , Correia A. Jorge 
Published: September 2019

Introdução: As válvulas da uretra posterior (VUP) são uma causa importante de obstrução congénita do trato urinário no sexo masculino, com repercussão na função vesical e renal. Neste estudo pretendeu-se caracterizar a clínica, tratamento, evolução e identificação de possíveis fatores de risco para doença renal crónica (DRC) de um grupo de crianças com VUP.
Métodos: Análise retrospetiva dos processos clínicos de crianças seguidas na Consulta de Nefrologia num hospital nível III entre janeiro 1999 e janeiro 2017. Variáveis analisadas: diagnóstico pré-natal, apresentação clínica, avaliação analítica e imagiológica, tratamento e evolução. Para análise estatística utilizou-se: Excel 2016® e Epi Info 7®, considerando-se significativo p < 0,05.
Resultados: Dos 23 casos de VUP incluídos no estudo, o diagnóstico foi sugerido por ecografia pré-natal em 16 e confirmado após nascimento, quatro tiveram diagnóstico no primeiro ano de vida e três depois dessa idade. As manifestações clínicas iniciais foram: lesão renal aguda (LRA) (n= 11), pielonefrite aguda (PNA) (n= 4) e alterações do jato urinário (n= 3). A mediana da creatinina (Cr) inicial foi 151 μmol/L. Todos apresentavam hidronefrose na ecografia pós-natal (bilateral em 22) 21 tinham alterações do parênquima renal e 19 espessamento parietal vesical. O diagnóstico foi realizado por cistografia radiológica, que também mostrou refluxo vesico-uretral (RVU) em 15 casos, bilateral em 10. Todas as crianças foram submetidas a fulguração, uma com vesicostomia prévia. O tempo médio de seguimento foi 7,5 anos, durante o qual 14 mantiveram PNA de repetição, sete RVU e 11 cursaram com disfunção vesical. Alguns casos necessitaram de outras intervenções cirúrgicas, que incluíram correção de RVU (n= 3) e nefrectomia unilateral (n= 2). Cinco (21,7%) evoluíram para DRC estadio ≥ 3, dos quais quatro iniciaram diálise com idade média de 9,3 anos. As PNA de repetição e o RVU bilateral associaram-se a evolução para o referido estadio (p 0,03 e p 0,049 respetivamente).
Conclusão: As VUP continuam a ser uma etiologia frequente da DRC na criança, apesar do diagnóstico e tratamento cada vez mais precoces.
Doação de Rins Após Paragem Cardiocirculatória: O Papel da Oxigenação por Membrana Extracorporal
Authors: Correia Ana Rita , Manso Margarida , Roncon-Albuquerque Jr. Roberto , Oliveira Gerardo , Silva Carlos , Cruz Francisco , Antunes-Lopes Tiago 
Published: September 2019

Introdução: A doença renal crónica é uma patologia prevalente, sendo significativo o número de doentes em estádio terminal cujas alternativas se resumem à terapêutica de substituição da função renal e ao transplante, sendo o último associado a maior qualidade de vida e a menor mortalidade. A procura crescente de rins para transplante tem aumentado o desfasamento relativamente aos rins disponíveis. Esse desfasamento impulsionou a pesquisa e desenvolvimento de alternativas aos dadores cadáver em morte cerebral, sendo os dadores após paragem cardiocirculatória uma alternativa viável. Estes obrigam a técnicas de preservação de órgão distintas, de forma a poder oferecer resultados funcionais sobreponíveis. O objetivo deste artigo foi rever a evidência recente sobre o papel da utilização da oxigenação por membrana extracorporal como técnica de preservação, na colheita de rins de dadores após paragem cardiocirculatória.
Material e Métodos: Foi efectuada uma pesquisa na base PubMed/MEDLINE, utilizando as expressões: “kidney transplantation”; “non-heart-beating donor”; “donation after cardiac death”; “extracorporeal membrane oxygenation”; “abdominal normothermic perfusion”. Com os artigos selecionados, realizou- se uma revisão não sistemática, sumarizando a evidência recente sobre a utilização da oxigenação por membrana extracorporal na colheita de rins de dadores após paragem cardiocirculatória.
Resultados: Verificou-se que os estudos sugerem com unanimidade que a oxigenação por membrana extracorporal é superior às outras técnicas de preservação utilizadas em dadores após paragem cardiocirculatória, uma vez que está associada a melhores resultados a curto prazo do aloenxerto renal. Relativamente aos dadores convencionais, em morte cerebral, a técnica permite resultado semelhantes, quando comparada com os dadores de morte cerebral de critérios expandidos.
Discussão: A preservação de órgãos através da oxigenação por membrana extracorporal nos dadores após paragem cardiocirculatória permite resultados funcionais favoráveis e, por esse motivo, poderá contribuir para o aumento do pool de dadores. As dificuldades logísticas associadas à implementação da técnica restringem a sua utilização.
Conclusão: A longo prazo, deverão ser criadas condições para a implementação em mais centros da oxigenação por membrana extracorporal nos dadores após paragem cardiocirculatória, aumentando o pool de rins disponíveis para transplante.
A Gencitabina como Alternativa Terapêutica na Ausência de BCG: A Experiência do CHLC (Hospital S. José)
Authors: Andrade Vanessa , Medeiros Mariana , Guimarães Tiago , Bernardino Rui , Falcão Gil , Fernandes Francisco , Farinha Rui , Calais da Silva Fernando , Campos Pinheiro Luís 
Published: September 2019

Introdução: Os tumores não músculo invasivos da bexiga devem ser estratificados em grupos de risco de forma a adequar o tratamento após cirurgia a cada doente. Nos tumores de alto risco deve ser realizada terapêutica adjuvante com bacilo de Calmette-Guérin (BCG) intravesical durante 1 a 3 anos. Têm sido reportadas roturas de stock de BCG intravesical, tendo sido o Centro Hospitalar de Lisboa Central (CHLC) afectado nos anos 2014 e 2015, o que obrigou a uma reformulação no tratamento dos doentes que tinham indicação para realização desta terapêutica. A gencitabina poderá ser uma alternativa válida, dado que alguns estudos mostram que poderá ter um papel nos doentes de risco intermédio, como alternativa à mitomicina C, e nos de alto risco, refractários à BCG, com um perfil de toxicidade mais favorável.
Material e Métodos: Trata-se de um estudo retrospectivo descritivo que incluiu doentes com tumores da bexiga não musculo-invasivos de alto risco, com início da doença em 2013/2014, afectados pelo período de escassez de BCG no Centro Hospitalar.
Resultados: No CHLC, 11 doentes com tumores de alto risco foram submetidos a terapêutica com gencitabina, apenas dois exclusivamente, os restantes sequencialmente com BCG. Apenas dois doentes, tratados com BCG e gencitabina, apresentaram recidiva tumoral. No entanto, um número significativo (6 em 11) sofreram efeitos adversos, dois dos quais que levaram à interrupção da terapêutica.
Conclusão: Aparentemente, a gencitabina foi uma boa alternativa de terapêutica adjuvante na ausência do tratamento gold standard (BCG), dada a existência de baixo número de recidivais tumorais, apesar do elevado número de efeitos adversos reportados.
Renal Failure Due to Sulfadiazine Induced Calculi: Case Report and Literature Review
Authors: Monteiro Sato Alexandre Augusto , Daud Lotaif Leda A. , Elias de Mattos Mario Henrique , Lopes Neto Antonio Corrêa 
Published: September 2019

Introduction: Renal calculi is a prevalent disease and has some causes described. The drug calculi origin are rare, accounting for around 1% to 2% of cases. The crystals of sulfadiazine are formed in 20% to 45% of cases, but between 0.4% and 4.5% are associated with renal failure. We present a case report and a review of the literature on diagnosis and treatment of this entity, given its rarity and specificity.
Case Report: A 48-year-old male, diabetic, during treatment for acute toxoplasmosis with sulfadiazine initiated renal colic associated with renal failure. The hypothesis of drug calculation was considered, because during the diagnostic investigation of toxoplasmosis, imaging studies were performed and presented without renal calculi. Initially he was treated conservatively with hyperhydration and alpha-blocker, but since he did not present improvement in the exams, he underwent ureterolithotripsy and double j stent.
Conclusion: We present a report of urinary lithiasis of pharmacological origin associated with renal insufficiency and a review of the literature.
Coxiella burnetii infection of the spine requiring neurosurgical intervention
Authors: Lundy Paige , Arnold Paul , Hance Kirk 
Published: September 2019

Background:
Infections from Coxiella burnetii, resulting in what is known as Q fever, are relatively rare and difficult to diagnose. Very few reports of spinal infection from C. burnetii have been reported rarely have these cases required surgical intervention.

Case Description:
We report a patient with the previous vascular surgery and Q fever spinal osteomyelitis. Previously reported cases with spinal involvement have described initial infection of vascular grafts in proximity to the spine. Literature on spinal infection from C. burnetii reports only one case that required surgical intervention of the spine. We report a patient with L5-S1 diskitis who required surgical intervention and subsequent percutaneous drainage.

Conclusion:
Spinal infections from C. burnetii are rare; however, in the setting of a patient with osteodiscitis with negative cultures as well as a history of significant vascular disease with stents, the diagnosis of Q fever should be entertained. Operative and interventional procedures should also be considered in these patients to help alleviate pain and maintain neurologic function.
Virtual reality simulation of neuroendovascular intervention improves procedure speed in a cohort of trainees
Authors: Dardick Joseph , Allen Stephanie , Scoco Aleka , Zampolin Richard L. , Altschul David J. 
Published: September 2019

Background:
Realistic virtual reality (VR) simulators have greatly expanded the tools available for training surgeons and interventionalists. While this technology is effective in improving performance in many fields, it has never been evaluated for neuroendovascular procedures. This study aims to determine whether VR is an effective tool for improving neuroendovascular skill among trainees.

Methods:
Trainees performed two VR revascularizations of a right-sided middle cerebral artery (MCA) thrombosis and their times to procedural benchmarks (time to enter internal carotid artery [ICA], traverse clot, and complete procedure) were compared. To determine whether the improvement was case specific, trainees with less procedural exposure were timed during VR left-sided ICA (LICA) aneurysm coiling before or after performing MCA thrombectomy simulations. To determine the value of observing simulations, medical students were timed during the right MCA revascularization simulations after watching other VR procedures.

Results:
Trainees significantly improved their time to every procedural benchmark during their second MCA revascularization (mean decrease = 1.08, 1.57, and 2.24 min; P = 0.0072, 0.0466, and 0.0230). In addition, time required to access the LICA during aneurysm coiling was shortened by 0.77 min for each previous VR right MCA revascularization performed (P = 0.0176; r2 = 0.71). Finally, medical students’ MCA revascularization simulation times improved by 0.87 min for each prior simulation viewed (P < 0.0221; r2 = 0.96).

Conclusion:
Both performance and viewing of simulated procedures produced significant decreases in time to reach neuroendovascular procedural benchmarks. These data show that VR simulation is a valuable tool for improving trainee skill in neuroendovascular procedures.
Cervical instability following artificial disc replacement
Authors: Kim Ki Joon , Gang Mun Soo , Bae Jung-Sik , Jang Jee Soo , Jang Il-Tae 
Published: September 2019

Background:
Although there has been increased interest in utilizing artificial disc replacement (ADR) techniques to treat cervical degenerative disease, few reports have focused on their postoperative complication and reoperation rates.

Case Description:
A 52-year-old male underwent the uneventful placement of a C5-C6 cervical ADR for disc disease and foraminal stenosis. One year later, he experienced the onset of severe neck pain attributed to instability of the ADR construct. This required removal of the C5-6 ADR and subsequent fusion.

Conclusion:
Strict adherence to appropriate criteria is critical for choosing when to place a cervical ADR. This requires documenting; adequate surgical indications, careful selection of the appropriate ADR device, meticulous surgical technique, proper preservation of the supporting structures, and sufficient neural decompression.
Phytochemical screening and Anti-oxidant activity of Ammannia octandra L.f
Authors: Kavitha G  , Sivakkumar T  , Elessy Abraham  
Published: September 2019

The investigation includes phytochemical screening of different extracts of Ammannia octandra L.f. Petroleum ether, Chloroform, Ethyl acetate, Ethanol as well as the aqueous extracts of Ammannia octandra L.f showed many phytoconstituents. The phytoconstituents of Ammannia octandra L.f were found to be glycosides, alkaloids, flavanoids, tannins and phenolic compounds. Antioxidant activity was determined for three extracts (Petroleum ether, ethyl acetate and ethanolic). DPPH assay, Superoxide free radical scavenging activity, Nitric oxide radical scavenging activity, Hydroxyl radical scavenging activity as well as Total antioxidant activity methods were followed for antioxidant assays. The ethanolic extract showed better antioxidant activity. Pharmacological screening of different therapeutic activities of Ammannia octandra L.f has to be carried out so that it may be used in future as a good natural antioxidant source.
Effect of ritonavir on pharmacokinetics of antimalarial drug combinations in rats
Authors: Sunitha G N  , Satyavati Dulipala D  , Girish Gudi  
Published: September 2019

The current treatment for Human Immunodeficiency Virus (HIV) patients coinfected with malaria involves the coadministration of antimalarial and antiretroviral (ARV) drugs. The World Health Organization (WHO) recommends artemisinin-based therapy for malaria that usually consists of artemether, artesunate or dihydroartemisinin with non-artemisinin derivatives such as amodiaquine, lumefantrine and mefloquine. Protease inhibitors (PI) such as ritonavir contribute to the improved health of HIV-positive individuals, and the inclusion of ritonavir in antiretroviral regimens is common in clinical practice. Ritonavir is a potent inhibitor of human CYP3A4, which is the primary enzyme involved in the metabolism of many of artemisinin-based drugs, as well as amodiaquine and proguanil. Upon co-administration, ritonavir can potentially influence the metabolism and thus increase the systemic exposure of these drugs. In order to understand this pharmacokinetic (PK) drug interaction, the current work evaluated the effect of ritonavir (50 mg/kg orally) on the PK of antimalarial drug combinations in Sprague Dawley (SD) rats. When co-administered with ritonavir, the exposure (AUC) of the antimalarial drugs artemether, artesunate and proguanil was increased by approximately 3.5-fold. Correspondingly, peak plasma concentrations (Cmax) of these drugs increased as well. There was no apparent influence of ritonavir on the PK of lumefantrine, amodiaquine and atovaquone. This study demonstrates the potential influence of ritonavir on the pharmacokinetics of at least some anti-malarial drugs, likely a result of inhibition of CYP3A. Further evaluation of clinically relevant drug interaction in humans may be warranted to ensure safe and effective use of anti-malarial and anti-HIV drugs concomitantly.
Comparison of Malondialdehyde Level in the Cord Blood of Newborn Infants of vaginal and cesarean deliveries
Authors: Eman Khammas ALSaadi  , Batol Faisal Taher  , Mohammed Abid Darweesh  , Mohammed Abul Al-Monther  
Published: September 2019

The oxidative stress injury that has been linked to poor perinatal outcome and birth asphyxia may be found even with normal pregnancy, and it is severity in a newborn may be related to modes of delivery for which our study aimed to identify. Furthermore, this study was aimed to study the effect of both related- maternal, and related neonatal characteristics on baby’s oxidative stress marker level (Malondialdehyde). Fifty newborn children were selected in both labor ward and operating theatre of Al-Sadder Teaching Hospital, Misan, Iraq. They were divided into two groups. The first group comprised 28 newborns, who were born by a vaginal delivery; the second group consisted of 22 newborns who delivered by elective cesarean section. The laboratory measurement of levels of an important antioxidant factor [malondialdehyde (MDA)] in baby’s cord blood has been extracted and used as an indicator of stress. We compared the two samples of different malondialdehyde levels in relation to variables as the delivery type, some maternal, fetal and neonatal characteristics. The results of this study revealed that MDA level was higher among neonates delivered through Elective Cesareans Section than those delivered through Vaginal Delivery with significant statistical value (p>0.0001). The previous delivery mood has a statistically significant value of (p>0.02) among mothers who had no previous deliveries. While there were no significant statistical values regarding maternal characteristics as (ages, parity, residency, antenatal care, history of previous abortion, and body mass index) as well as fetal and neonatal characteristics as (sex, birth weight, fetal presentation, and Apgar score) and high MDA level. The current study was concluded that babies delivered by Elective Cesarean Section had been exposed to more oxidative stress compared to the normal Vaginal Deliveries especially for the Primigravidas.
Preliminary phytochemical screening and anticancer potential of Kohautia aspera (Heyne Ex Roth) Bremek
Authors: Kavitha G  , Sivakkumar T  , Elessy Abraham  
Published: September 2019

Phytochemical screening followed by anticancer potential evaluation of Kohautia aspera (Heyne ex Roth) Bremek was the purpose of the study. Successive extraction was performed with four solvents of different polarity as well as hot percolation method for the aqueous extract. The anticancer potential of the plant was investigated by standard MTT assay against (MCF-7) human breast adenocarcinoma cells. The extracts showed many phytoconstituents. In vitro cytotoxic activity of plant increased with increasing concentration of extracts. The presence of important phytoconstituents in plants may provide protection against a number of diseases. The investigation concludes that Kohautia aspera (Heyne ex Roth) Bremek possesses significant anticancer potential.