bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between ethylene oxide exposure and biological age acceleration: evidence from NHANES 2013–2016
Authors: Chen Xinyun , Shi Fangyu , Yu Wenhui , He Chunying , Gou Shenju , Fu Ping 
Published: November 2024

IntroductionPopulation aging is a global concern, with the World Health Organization predicting that by 2030, one in six individuals worldwide will be 60 years or older. Ethylene oxide (EO) is a widely used industrial chemical with potential health risks, including associations with age-related diseases. This study investigates the relationship between EO exposure and biological age acceleration.MethodData from the National Health and Nutrition Examination Survey (NHANES) 2013–2016 were analyzed, including 3,155 participants after exclusions. Blood EO levels were measured using hemoglobin adducts (HbEO). Biological age acceleration was assessed using two methods: Phenotypic Age Acceleration (PhenoAgeAccel) and Klemera-Doubal Method Age Acceleration (KDM-AA). Linear and logistic regression models were applied, adjusting for various covariates, and restricted cubic spline (RCS) regression was used to explore non-linear associations.ResultsHigher EO exposure was significantly associated with increased PhenoAgeAccel and KDM-AA across all models. In the continuous model, substantial positive associations were observed (PhenoAgeAccel: β = 0.73, p &lt; 0.001; KDM-AA: β = 0.66, p &lt; 0.001) in Model 3. Quintile analysis indicated a trend of increasing biological age acceleration with higher EO exposure. RCS regression demonstrated a significant linear relationship between EO exposure and PhenoAgeAccel (p for non-linearity = 0.067), as well as with KDM-AA (p for non-linearity = 0.083). Subgroup and interaction analyses revealed significant modifying effects by factors such as body mass index, gender, diabetes status, and physical activity level.ConclusionOur study demonstrates a significant association between EO exposure and accelerated biological aging. These findings highlight the need for further prospective and mechanistic studies to validate and explore this phenomenon.
Development of the Bisphenol A exposure scale in adults
Authors: Kaplan Betül , Ortabağ Tülay , Aslan Ekrem 
Published: November 2024

ObjectiveThis study was conducted to develop a scale for assessing the attitudes of adults regarding the determination of Bisphenol A exposure.MethodsThe study sample comprised of 370 individuals who volunteered to participate. According to the Explanatory Factor Analysis (EFA) results of the investigation, a scale structure consisting of a total of 3 sub-dimensions was obtained. In the Confirmatory Factor Analysis, the scale item factor loading values were acceptable.ResultsThe fit indices for the scale were CMIN/df = 1,618, RMSEA = 0.058, NFI = 0.914, CFI = 0.965, and IFI = 0.790, indicating a satisfactory level of agreement. The scale was determined to have a Cronbach value of 0.79 and a high degree of reliability. The item-total score correlation coefficients of the scale ranged from 0.327 to 0.534 and exhibited a high degree of discrimination, as determined.ConclusionBased on the analyses conducted, it was determined that the Adult Bisphenol A Exposure Scale is a valid and reliable instrument for determining the attitudes of adults toward contact with and use of Bisphenol A-containing products.
Endometrial scratching and intralipid treatment—no general recommendations
Authors: Mrosk Paolina , Sandi-Monroy Nathallie , Gagsteiger Friedrich , Friedl Thomas Wolfram Paul , Hancke Katharina , Bundschu Karin 
Published: November 2024

ObjectivesEndometrial scratching (ES) and/or intravenous intralipid therapy (in cases of increased uterine natural killer cells, uNKs) are still conducted in several fertility centers as “add-on” treatments in patients undergoing ART, although convincing evidence for beneficial effects is lacking.Study designIn this retrospective study, associations between ES treatment or additional intralipid therapy and pregnancy and live birth rates of 1,546 patients undergoing 2,821 IVF-/ICSI-treatment cycles with fresh or frozen embryo transfers in a German fertility-center between 1st January 2014 and 31th May 2017 were analyzed.ResultsOverall pregnancy and live birth rates for all 2,821 treatment cycles (468 cycles with ES) were 32.8% and 23.5%. There were no statistically significant differences in pregnancy or live birth rates between first treatment cycles with and without ES (p = 0.915 and p = 0.577) or between second cycles following an unsuccessful first cycle with and without ES (p = 0.752 and p = 0.623). These results were confirmed using multivariable generalized estimating equations (GEE) models accounting for non-independency of multiple treatment cycles per patients that included all cycles and showed no significant effect of ES on pregnancy (p = 0.449) or live birth rates (p = 0.976). Likewise, a GEE model revealed no significant effect of intralipid treatment on pregnancy (p = 0.926) and live birth rates (p = 0.727).ConclusionsOur results reveal no evidence that ES increases the pregnancy or live birth rates in women undergoing their first or further IVF cycle with fresh or frozen embryo transfer. Intralipid treatment was also not beneficial. Even if patients explicitly ask for it, these procedures are not recommended outside of clinical studies.
Open surgery for carpal tunnel syndrome: is it necessary to release the antebrachial fascia? A randomized clinical trial study
Authors: Razavipour Mehran , Taheri Sadegh , Abdollahi Amirsaleh , Yahaghi Yazdan 
Published: November 2024

BackgroundOpen surgery for carpal tunnel syndrome (CTS) has historically involved release of the antebrachial fascia. The benefit of antebrachial fascia release in CTS surgery is still controversial. So, this study was designed to evaluate this hypothesis.MethodsThe study was designed as a two-arm randomized clinical trial study. Patients diagnosed with bilateral carpal tunnel syndrome were enrolled in the study, while those under 18 years of age and those with a history of carpal tunnel release, trauma to the spine, shoulder, or elbow, rheumatologic disease, inflammatory arthropathy, and CTS onset during pregnancy were excluded. The hands of the eligible patients were randomly assigned to two surgical groups. In the first group, the antebrachial fascia was opened to the proximal part, while in the second group, the fascia was opened from the central part of the deep layer to the distal volar part of the wrist. Pain severity, grip and pinch strength, symptom severity, and functional status were evaluated by the visual analog scale, the SAEHAN® hydraulic handgrip and pinch dynamometer, and the Boston Carpal Tunnel Questionnaire (BCTQ), respectively, at the baseline and 1, 3, and 6 months after surgery.ResultsFinally, 230 patients (220 women and 10 men, 460 hands) completed the study. The mean age of the patients was 50.4 ± 8.4 years. In both open surgery groups with and without antebrachial fascia release, the grip and pinch strength, BCTQ scores, and pain severity significantly improved at the end of the study (P &lt; 0.01), but there was no statistically significant difference between the two groups (P &gt; 0.05). Patient satisfaction improved in both groups; again, no significant difference was observed between the two groups (P &gt; 0.05).ConclusionBoth open CTS surgery with and without antebrachial fascia release show the same clinical and functional outcomes. Therefore, avoiding the release of the antebrachial fascia preserves proprioception and prevents iatrogenic injury to the median nerve and its branches. Conversely, a blunt release of the antebrachial fascia does not adversely affect the outcome.
Clinical Trial Registrationhttps://irct.behdasht.gov.ir/search/result?query=@irct_id:IRCT2012103111341N1, Identifier: IRCTID: IRCT2012103111341N1.
S100A4 targets PPP1CA/IL-17 to inhibit the senescence of sheep endometrial epithelial cells
Authors: Jiao Xiyao , Jiao Yaoxuan , Cui Jingwen , Zhang Haorui , Li Xiangyun , Chu Zhili , Wu Xinglong 
Published: November 2024

BackgroundGonadotropin-releasing hormone (GnRH) is commonly used in animal reproduction and production, but it was previously reported that GnRH decreases the embryo implantation rate during artificial insemination or embryo transfer in sheep. In addition to the finding that GnRH can target S100A4 to inhibit endometrial epithelial cells proliferation, it was also found that endometrial cells were in poor condition and experienced cell death in S100A4 knockout mice, but the mechanism is unclear.MethodsThe protein PPP1CA, which interacts with S100A4, was detected by immunoprecipitation-mass spectrometry of overexpression and knockdown of S100A4 and PPP1CA. The effect of S100A4 and PPP1CA on cell senescence was detected by Galactosidase staining. To further reveal the mechanism effect of S100A4 and PPP1CA on cell senescence, transcriptome sequencing was conducted. Additionally, in vivo experiments were performed to assess PPP1CA protein expression in the endometrial tissue of S100A4 knockout mice.ResultsS100A4 inhibited cell senescence by activating PPP1CA, while PPP1CA overexpression suppressed the activation of the IL-17 signaling pathway. Inhibition of the IL-17 signaling pathway inhibited the senescence of endometrial cells.ConclusionS100A4 can target the PPP1CA/IL-17 signaling pathway and inhibit endometrial epithelial cell senescence.
The Performance of the manual and Sofia rapid antigen test in medical staff exposed to Omicron variants
Authors: Guanche Garcell Humberto , Vargas Girón Eduardo , Gonzalez Perez Sandra Ibis , Felipe Garmendia Angel M , Gutierrez Garcia Francisco 
Published: November 2024

Background: Variable COVID-19 rapid antigen test sensitivity had been reported and the effect of viral variants focus the attention due to impact in the early detection of cases. Objective: To compare the performance of antigen tests (manual RAT, and Sofia test) in medical staff exposed during the circulation periods of different Omicron variants. Methods: Descriptive study of samples collected for the diagnosis of SARS-CoV-2 infection in medical staff at TCH Hospital from December 2021 to December 2022, including cases confirmed by SARS CoV-2 PCR, and a RAT. Dec 2021 - March 2022 and June-Dec 2022 were considered the periods of Omicron BA.1.1. variants and Omicron BA.4/5 respectively. Comparison of Ct figures between categories was carried out using the Wilcoxon-Mann-Whitney test, and sensitivity (95% confidence intervals) were calculated. Results: 287 healthcare workers were confirmed with COVID-19 during the study period, 56.1% during B.1.1. variant period, and 43.9% during B.4/5 variants predominant circulation. Sensitivity of the manual RAT test (82.5%; 95% CI 73.4 - 89.4) was higher during B.1.1. variant circulation in comparison with the B.4/5 period (68.9%;53.4-81.8). These two methods during this B.4/5 period had quite similar sensitivity figures when compared to each other; manual 68.9% (95% CI 53.4 - 81.8) and Sofia 72.7% (95% CI 60.4 - 83.0). Conclusion: The variation in sensitivity of the RAT for SARS CoV-2 variants and the similar performance of manual and SOFIA methods of RAT could be considered in the diagnostic approach of COVID-19 and the appropriate isolation of potentially infectious cases.
АПОЛЛОН НИКОЛАЕВИЧ МОКРИЦКИЙ - УЧЕНИК А.Г.ВЕНЕЦИАНОВА И ПОСЛЕДОВАТЕЛЬ К.П.БРЮЛЛОВА: К ВОПРОСУ ОБ ЭВОЛЮЦИИ ВЗГЛЯДОВ НА ХУДОЖЕСТВЕННЫЙ МЕТОД
Authors: Елена Андреевна Шарова 
Published: November 2024

Статья посвящена художнику, педагогу и яркому представителю художественной среды 1830-1860-х годов Аполлону Николаевичу Мокрицкому. Значение Мокрицкого для русской художественной культуры определяется не столько его живописными произведениями, сколько эпистолярным наследием. Именно оно позволяет рассмотреть фигуру А.Н. Мокрицкого как ученика А.Г. Венецианова, с одной стороны, и как последователя К.П. Брюллова, - с другой. Особое внимание уделено воззрениям Мокрицкого, определяющим суть художественного метода каждого из своих наставников. Проанализированы суждения Мокрицкого в качестве непосредственного представителя и обозревателя художественной ситуации второй трети XIX века и занимаемая по отношению к нему позиция ученых XX века.
The article focuses on the artist, teacher and outstanding representative of artistic milieu of 1830 - 1860th - Apollon Nikolaevich Mokritsky. The author notes that the significance of Mokritsky for Russian art culture is determined not so much by his art works as by his epistolary heritage. That’s it allows us to consider the figure of Apollon Mokritsky from the one hand as a student of A. Venetsianov and from the other hand as a follower of K. Briullov. Particular attention is paid to the Mokritsky’s views, which define the essence of the artistic method of each of his mentors. Mokritsky’s judgments as a direct representative and observer of the artistic situation of the second third of the nineteenth century and the position of scientists of the twentieth century with respect to him were analyzed.
КРЕСТОВЫЕ ПОХОДЫ В РУССКОЙ КУЛЬТУРНОЙ РЕФЛЕКСИИ
Authors: Нина Федоровна Сокольская 
Published: November 2024

Представлена рецензия на книгу С.И. Лучицкой ≪Крестовые походы: идея и реальность≫. В книге предлагается совершенно иной взгляд на крестоносное движение, которое рассматривается в широком контексте социально-политических процессов, происходивших в Европе в Средние века.
A review of S.I. Luchitskaya's book "The Crusades: Idea and Reality" is presented. The book offers a completely different view of the crusader movement, which is considered in the broad context of the socio-political processes that took place in Europe in the Middle Ages.
СОХРАНЕНИЕ ЦЕРКОВНОГО ОБЪЕКТА: ОПЫТ МУЗЕЙНО-ЦЕРКОВНОГО ВЗАИМОДЕЙСТВИЯ (НА ПРИМЕРЕ СМОЛЕНСКОГО СОБОРА НОВОДЕВИЧЬЕГО МОНАСТЫРЯ В МОСКВЕ В ХХ В.)
Authors: Ирина Олеговна Ивановская 
Published: November 2024

Социокультурная ситуация ХХ века не была стабильной. Тем не менее, культовые объекты сохранялись в условиях смены эксплуатирующей организации. Профессиональное и церковное взаимодействие в вопросах наблюдения за сохранностью храмов в этот период изменялось по интенсивности: от индифферентного присутствия на объекте до эффективного сотрудничества. В статье прослеживается преемственность курирования Смоленского собора Новодевичьего монастыря в Москве на протяжении столетия.
The sociocultural situation of the XX century was not stable. But cult objects were preserved during the change of the operating organization. Professional and church interaction in monitoring the preservation of temples during this period varied in intensity: from an indifferent presence at the facility to effective cooperation. In the article, the author traces the continuity of curation of the Smolensk Cathedral of the Novodevichy Convent in Moscow for a century.
НЕФОРМАЛЬНЫЕ ОРГАНИЗАЦИИ РОССИЙСКОЙ МОЛОДЕЖИ ВО ВТОРОЙ ПОЛОВИНЕ 1940-х - НАЧАЛЕ 1950-х гг
Authors: Галина Михайловна Иванова 
Published: November 2024

В фокусе исследования находятся неформальные объединения молодежи на территории РСФСР, попавшие во второй половине 1940-х - начале 1950-х гг. под удар сталинских репрессий в качестве «нелегальных антисоветских организаций». Раскрываются причины и условия их возникновения, анализируется количественный, половозрастной и социальный состав участников молодежных групп и кружков, исследуется механизм репрессий в отношении советской молодежи.
The research focuses on informal youth associations on the territory of the RSFSR, which came to be under the blow of Stalinist repressions as "illegal anti-Soviet organizations" in the second half of the 1940s - early 1950s. The reasons and conditions for their occurrence are revealed, the quantitative, gender, age and social composition of the participants in youth groups and circles is analyzed, the mechanism of repression against Soviet youth is investigated.
СОЦИОКУЛЬТУРНОЕ ЗНАЧЕНИЕ ТРАМ’ОВСКОГО ДВИЖЕНИЯ В ПРИМОРЬЕ В 1930-е гг
Authors: Виталий Владимирович Карпеченко 
Published: November 2024

Предметом исследования является социокультурная значимость «театров рабочей молодежи» - ТРАМ’ов в Приморском крае в 1930-е гг. Опираясь на данные периодики, автор анализирует роль местного ТРАМ’овского движения, его задачи, особенности функционирования и отличительные черты, из чего складывается степень его социокультурного влияния на культурную жизнь Приморья.
The subject of the research is the socio-cultural significance of «theaters of working youth» in the Primorsky Territory in the 1930s. In the history of theatrical culture of the Russian Far East, the activities of «theaters of working youth» have not been fully analyzed. In the 1930s. in the Primorsky region, amateur performances are developing, a new stage tradition of the Soviet amateur theater is being formed. Based on the data from periodicals, the author analyzes the role of the local of «theaters of working youth movement», its tasks, functioning features and distinctive features, which make up the degree of its socio-cultural influence on the cultural life of Primorye.
ТВОРЧЕСКИЙ ПУТЬ ХУДОЖНИКА ДМИТРИЯ КЛОПОВА1
Authors: Андрей Владимирович Кортович 
Published: November 2024

Исследуется творчество художника Д.М. Клопова, близкого друга и земляка писателя Ф.А. Абрамова. Рассматриваются основные этапы биографии художника и характерные особенности авторского почерка его изобразительного искусства.
For the first time in art history, the article examines the work of the artist D.M. Klopov, a close friend and fellow compatriot of the writer F.A. Abramov. The main stages of the artist’s biography and the characteristic features of the author’s style of his fine art are considered. The article was prepared on the basis of the report presented at the IV All-Russian Scientific Conference «Russian North-2020. Problems of studying and preserving the historical, cultural and natural heritage», Totma town.
НОВЫЙ ЭТАП ВЗАИМНОЙ ИНТЕГРАЦИИ СФЕРЫ КУЛЬТУРЫ И ТУРИЗМА
Authors: Юрий Степанович Путрик 
Published: November 2024

Взаимодействие культуры и туризма наиболее ощутимо проявляется на примерах использования объектов культурного наследия как мотиватора туристских поездок и путешествий. Интеграционный процесс этих двух сфер получает новые импульсы в своем развитии благодаря цифровизации, которая все больше охватывает самые различные сферы жизни и деятельности людей. В сфере сохранения и использования объектов культурного и природного наследия цифровые технологии пока не получают достаточного развития. Создание цифровой платформы в области сохранения и туристского использования наследия позволит выйти на новый качественный уровень координации и управления процессами сохранения и туристского использования наследия.
The interaction of culture and tourism is most tangibly manifested in the examples of the use of cultural heritage objects as a motivator for tourist trips and travel. The integration process of these two spheres receives new impulses in its development thanks to digitalization, which increasingly covers the most diverse spheres of people's lives and activities. In the field of preserving and using objects of cultural and natural heritage, digital technologies are not yet sufficiently developed. The creation of a digital platform in the field of conservation and tourist use of heritage will allow reaching a new qualitative level of coordination and management of the processes of conservation and tourist use of heritage.
КУЛЬТУРНОЕ НАСЛЕДИЕ СРЕДНЕГО УРАЛА: ДУХОВНЫЕ СТИХИ ИЗ ВЕРХ-НЕЙВИНСКОГО
Authors: Ирина Семеновна Колесова 
Published: November 2024

Представлены образцы духовных стихов, записанные в поселке Верх-Нейвинском Свердловской области, имеющие отношение к кругу сербишинской православной общины. Открываются новые аспекты религиозного сознания жителей Среднего Урала, проблемы идейной диффузии, взаимодействия стихотворных и певческих традиций.
The paper are represented standards spiritual verses from the Verkh-Neyvinsky Sverdlovsk region. These materials, related to the Serbishin Monastery, have historical valueю. They discover new aspects in studying interplay spiritual and poetic Orthodox and Old Believer traditions, actualize the problem about lack of knowledge on this topic.
РУССКАЯ И УКРАИНСКАЯ СВАДЬБЫ В КОНТЕКСТЕ ВОСТОЧНОСЛАВЯНСКОГО ФОЛЬКЛОРА: ТРАДИЦИИ, ОБРЯДЫ, ПЕСНИ, КОСТЮМ
Authors: Людмила Николаевна Михеева , Магда Алексеевна Джичоная 
Published: November 2024

Анализируются особенности свадебного обряда у русских и украинцев. Подчеркивается близость обрядов в контексте восточнославянского фольклора (в традициях, костюмах), сочетание языческих и христианских элементов. Фольклор рассматривается как локальная художественная культура, составная часть традиционной этнической культуры.
The article analyzes the features of the wedding ceremony among Russians and Ukrainians. The author emphasizes the proximity of rituals in the context of East Slavic folklore (in traditions, costumes), the combination of pagan and Christian elements. Folklore is considered as a local artistic culture, an integral part of traditional ethnic culture.
МЕТОД РЕЖИССЕРСКОГО АНАЛИЗА СПЕКТАКЛЯ: АКСИОЛОГИЧЕСКИЙ ПОДХОД (В КОНТЕКСТЕ ПРЕПОДАВАНИЯ ДИСЦИПЛИНЫ «ОСНОВЫ РЕЖИССУРЫ»)
Authors: Олеся Витальевна Гришанина-Мошкина 
Published: November 2024

Рассматривается метод режиссерского анализа спектакля в обучении студентов театрального факультета (по большей части режиссеров) с точки зрения аксиологического подхода, нацеленного на духовно-нравственное развитие общества. Представлен структурно-логический план режиссерского анализа спектакля, алгоритм действия (в обобщенном варианте), показаны взаимосвязи элементов.
The method of the director's analysis of the performance in the training of students of the theater faculty, mostly directors, is considered. The study is conducted from the point of view of the axiological approach. Being one of the leading methods in this direction of training, it allows you to bring up not just a deep, harmoniously developed personality, capable of an effective reflexive process from the point of view of directing a performance, but a professional who puts humanistic ideas, value components of the spiritual and moral development of society as the basis for his work. The study presents a structural and logical plan for the director's analysis of the performance. It shows the algorithm of the action in a generalized version. All the points and elements that follow each other define a clear interdependence and connection.
ПОЛИТИКА КОМПЛЕКТОВАНИЯ ФОНДА СОВРЕМЕННОГО РИСУНКА ГОСУДАРСТВЕННОЙ ТРЕТЬЯКОВСКОЙ ГАЛЕРЕИ В СОЦИОКУЛЬТУРНОМ КОНТЕКСТЕ 1930-Х ГГ.
Authors: Дарья Александровна Петрова 
Published: November 2024

Статья посвящена изучению исторического опыта Третьяковской галереи в области формирования коллекции современного рисунка. Анализируется влияние социокультурных факторов на принципы, критерии и формы комплектования коллекции в 1930-е гг.
The article is devoted to the study of the historical experience of the Tretyakov Gallery in the formation of a collection of modern drawings. The influence of socio-cultural factors on the principles, criteria and forms of collection acquisition in the 1930s is analyzed.
ФОЛЬКЛОРНАЯ ТРАДИЦИЯ В КОНТЕКСТЕ СОВЕТСКОЙ КУЛЬТУРЫ
Authors: Галина Александровна Цветкова 
Published: November 2024

Рассматривается политика советского государства в сфере культуры, место и роль фольклорной традиции в культурной революции. Выделяются этапы дифференциации, адаптации и интеграции традиции в советскую культуру и партийные категории социально-классового, идейно-политического, этно-национальный сопряжения традиции и коммунизма в культуре СССР.
The policy of the Soviet state in the sphere of culture, the place and role of the folklore tradition in the cultural revolution are considered. The stages of differentiation, adaptation and integration of tradition into Soviet culture and party categories of socio-class, ideological-political, ethno-national conjugation of tradition and communism in the culture of the USSR are highlighted.