bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
Authors: Cadete Martini Alessandra , Gomez-Arboledas Angela , Forner Stefania , Rodriguez-Ortiz Carlos J. , McQuade Amanda , Danhash Emma , Phan Jimmy , Javonillo Dominic , Ha Jordan-Vu , Tram Melanie , Trujillo-Estrada Laura , da Cunha Celia , Ager Rahasson R. , Davila Jose C. , Kitazawa Masashi , Blurton-Jones Mathew , Gutierrez Antonia , Baglietto-Vargas David , Medeiros Rodrigo , LaFerla Frank M. 
Published: October 2019

Significance
As we age, the innate immune system becomes dysregulated and is characterized by persistent inflammatory responses, and the chronic inflammation mediated by inflammatory receptors represents a key mechanism by which amyloid-beta (Aβ) drives the development of cognitive decline in Alzheimer’s disease (AD). A crucial aspect of this process is a failure to resolve inflammation, which involves the suppression of inflammatory cell influx and the endocytosis of inflammatory receptors. We found that ablation of the endosomal adaptor target of Myb1 (TOM1) worsens neuroinflammation, impairs microglial phagocytosis, and significantly exacerbates amyloid deposition. Conversely, restoration of TOM1 reverses these effects and reduces Aβ pathology. These results highlight the importance of endosomal adaptors and their interaction with inflammatory receptors in the pathogenesis of AD.
Coherence relations in research article discussions
Authors: Kawase Tomoyuki 
Published: October 2019

Abstract
Constructing a coherent text and achieving genre-specific communicative purposes are crucial aspects of academic
writing. However, to date, it remains unclear how coherence and genre are related to each other conceptually. This paper seeks to
extend previous research on the influence of genre on coherence relations by examining how writers of applied linguistics research
articles (RAs) organise sentences in the discussion section to achieve communicative purposes of the RA discussion genre. The
analyses suggest that the writers of the selected discussions might have related sentences to each other differently depending on
the purposes they sought to achieve. Possible reasons for relational features are considered in light of the nature of the RA
discussion genre and/or the applied linguistics discipline.
The Musico-Poetics of the Flat Submediant in Schubert's Songs
Authors: Bretherton David 
Published: October 2019

AbstractComposers' increasing and increasingly evocative use of chromatic mediants during the first few decades of the nineteenth century is arguably a hallmark of early Romantic harmony. The apparent association in Schubert's songs between ♭VI and the representation of utopia, fantasy, reverie, dreams and other positive, other-worldly states has been noted by many scholars. However, the fact that he also occasionally employed ♭VI to portray darker sentiments is rarely commented on and questions the degree to which the ♭VI harmony itself acts as a positive, other-worldly signifier. This article accounts for these various opposing uses and proposes that surface voice-leading details (ones that are often overlooked by Schenkerian and neo-Riemannian approaches) are key to understanding the musico-poetics of ♭VI in Schubert's songs.
Notation Cultures: Towards an Ethnomusicology of Notation
Authors: Schuiling Floris 
Published: October 2019

AbstractThe ubiquity and diversity of notational practices in music suggest that notation is a significant part of human beings' musicking behaviour. However, it is difficult to address its function since the usual conception of notation in music scholarship is at odds with studying performance in the first place. This article presents a methodological outline for an ethnomusicology of music notation by investigating the musicality of notation not in terms of its representation of musical structures, but in terms of its mediation of the social and creative agency of musicians. It is suggested that, rather than detracting from musical reality, notation composes musical cultures. This constructive work is simultaneously ontological and ethical. It is described in terms of three distinct processes, namely mobilization, entextualization and remediation. In doing so, this article presents an interdisciplinary approach to a topic that has traditionally defined the disciplinary centre of music scholarship.
Analysis of intrinsic value and estimating losses of “blue carbon” in coastal wetlands: a case study of Yancheng, China
Authors: Zang Zheng 
Published: October 2019

ABSTRACT

Introduction:
Large stocks of “blue carbon” exist in the ecosystems of coastal wetlands. This paper presents a case study of the Chinese city of Yancheng. First, through field surveys and laboratory analysis, changes in the organic carbon (OC) content in typical plant communities throughout the study area are described in detail. Second, an OC burial rate and economic value model is constructed to analyze the composition of the carbon sink values.

Outcomes/other:
The results are as follows: Of the typical plant communities,
Spartina alterniflora
has the highest OC content (5.80 g·kg-1), followed by
Suaeda glauca
(4.78 g·kg-1) and
Phragmites australis
(3.76 g·kg-1); the contemporary OC sedimentation rates are 2.01, 1.48, and 1.22 cm·yr-1, respectively.
Spartina alterniflora
communities have the highest annual average carbon sink value ($418.74/ha) in the study area, followed by
Phragmites australis
($176.29/ha) and
Suaeda glauca
($101.54/ha).

Discussion:
As a result of both the expansion of the Spartina alterniflora area and coastal erosion, the total OC value since 1987 has displayed two-stage characteristics: it first increased and then decreased.

Conclusion:
In recent years, the annual average decline in OC value has ranged from approximately $82,100 to $123,100 (reference: the Sweden carbon tax provided by the World Bank, 130$/ton)
Crack detection in rotating shafts using combined wavelet analysis
Authors: Pricop M , Pazara T , Pricop C , Novac G 
Published: October 2019

Abstract
There are many rotating mechanical systems on board ships that comprise the main shaft transmission element. Proper functioning of shafts depends on many factors: alignment system, connections with other elements - couplings, gearboxes, bearing elements with ball bearings or bushings, operated regime, and al. All these factors can lead to fatigue of the shaft over time and to appearance of internal/external cracks which can determine a total damage of the shaft at some point in time. To avoid these disasters the operation of these rotating systems is monitored based on vibration analysis of recorded signals (FFT and DFT analysis). Due to the transient modes and the presence of the noise, the processing of the recorded signals must be performed with methods that present a good resolution simultaneously in the time and frequency domain. In the paper, measurements are made on a stand with a rotating system and it is determined the influence of some factors (measuring points and directions, speed, operated mode, crack size, presence of misalignment, noise) on the quality of the Wavelet Transform results. In order to improve the clarity of amplitudes and frequencies changes at the initiation of shaft cracks, the authors are proposing the combined use of Continuous Wavelet Transform (CWT), Discrete Wavelet Transform (DWT) and Wavelet Packet Transform (WPT). The authors propose using power spectral density (PSD) as it is a method with good performance in detecting faults in rotating machines.
Importance of the water transport sector for Romania’s economy
Authors: Nistor F , Popa C 
Published: October 2019

Abstract
The importance of the transport sector for the national economy is given by its impact on growth, employment and sustainable development. The transport sector corresponds to the volume of goods exported or imported. According to EU data, transport and storage costs ma y account for up to 15% of the value of a finished product. Competitive maritime transport can provide many benefits for both the national and local economy. Port activity is complementary to maritime transport and involves the development of services related to transport. In Romania, the involvement of the private sector in water transport activities is confirmed by the over 200 active enterprises in 2017. The present paper highlights the place and role of the water transport sector for the national, regional and local economy by considering the importance of Romania on the map of European trade and the EU transport network.
Study of chilled water plant heat exchange for special ships
Authors: Volintiru O N , Scurtu I C , Stefanescu T M 
Published: October 2019

Abstract
The sizing of the air conditioning chilled water plant components shall be carried out considering both the summer and winter operating modes. Some devices are used in both modes, and others only in one of two working loads. Depending on the sources of harmful substances from the air conditioning spaces served, can be selected one of the following air recirculation systems: no recirculation (complete replacement with fresh air); partial recirculation (partial replacement of vicious air with fresh air); total recirculation (no fresh air injection).
Fractal analysis in diagnostic printing in cases of neurodegenerative disorder: Alzheimer type
Authors: Prada D , Avilés R , Prada E , Rojas F , Mieles I , Cerquera A 
Published: October 2019

Abstract
Alzheimer’s disease is a degenerative neurological disorder that comes with the aging process characterized by cognitive, affective and behavioral deficits. a possible method that can support the diagnosis and treatment of Alzheimer’s disease is called fractal geometry, given that the brain has fractal structure, therefore, Alzheimer’s disease is an observed progressive process of alterations within the groups of topographic voxels, which means that a geometrical fractal analysis can support the diagnosis of the disease. For this purpose, a double blind clinical trial study was designed, calculating the fractal dimension and the lagunarity of magnetic resonance imaging of the cerebral cortex of patients with the neurological report of Alzheimer’s disease, implementing the box-counting method or “entropy of kolmogorov”, by means of a software with logarithm FracLac (p=1.029). As a relevant result, a characteristic fractal pattern was evidenced in the images of patients with Alzheimer’s disease, which allowed to postulate the mathematical method as a possible analysis to complement the clinical order in the diagnostic assessment.
Cathedral bell’s San José de Cúcuta: Heritage and acoustics
Authors: Vergel-Ortega M , Delgado J A , Díaz Umaña Y 
Published: October 2019

Abstract
The objective of this research was to analyze the characteristics of the bells and dynamic particularities of the bell tower of the cathedral of San José de Cúcuta, Norte de Santander, Colombia. The research had a mixed methodological approach, using a simplified numerical model of the structure. The spectrum of structural response is determined, analyzing according to the bells, magnitudes of the function of variable forces, with the time that they introduce on the structure with their own weight, speed of rotation and inertia; the most unfavorable dynamic amplification factor and response for quasi-static analysis for forces is determined. It is concluded that the bell of greater weight introduces greater efforts in the tower, being the location of the bell a direct incident factor.
Population dynamics in the face of climate change: Analysis of a cubic thermal performance curve in ectotherms
Authors: Saldaña-Núñez V , Córdova-Lepe F , Moreno-Gómez F N 
Published: October 2019

Abstract
The objective of this study is to perform an analysis on the effect of the increase in temperature under the context of climate change on the dynamics of a population of ectothermic organisms, which are highly susceptible to these changes, as their body temperatures depend crucially on the environmental temperature. In our modelling approach, population abundance is governed by a logistic growth, where the intrinsic growth rate is affected by the change in temperature. The relationship between environmental temperature and the intrinsic rate of increase will be represented by a thermal performance curve type. In order to facilitate analytical simplicity but also novelty, a cubic expression is proposed to represent the thermal performance curve, the intensity of intraspecific competition is considered to remain constant and the tendency of temperature increase follows a linear expression. Finally, consequences on the trends of population abundance curves are assessed.
Study and design of a parking meter system
Authors: Orjuela Abril M S , Rojas Suárez J P , Prada Botía G C 
Published: October 2019

Abstract
The automobile is the main means of transportation in most cities of the world, however, its excessive use has generated several environmental and social problems, one of them is the lack of control over parking on public roads, affecting vehicle traffic, disturbing the image of the city, increasing the rate of accidents and causing negative effects on the mood of drivers and pedestrians. There are different alternatives to reduce these indicators, highlighting the effectiveness of the implementation of parking meter systems, which seek to regulate parking on public roads through a fee and a time limit. This article demonstrates the design, feasibility and impact (economic, social and environmental) of an implementation of the parking meter system in the center of the city of San José de Cúcuta, Colombia, with data from the Secretariat of Transit of the metropolitan area of the city of San José de Cúcuta, Colombia and the national institute of roads, achieving a solution to the problem of traffic congestion in the city and also contributing to create citizen culture among its inhabitants.
Curricular trends in the Universidad Francisco de Paula Santander academic program offerings
Authors: Parra-López H , Rojas-Suárez J P , Vergel-Ortega M 
Published: October 2019

Abstract
The objective of the research work, was to analyze the curriculum of the programs from “Universidad Francisco de Paula Santander” in San José de Cucuta, Colombia. The sample was participatory non-probability, with the participation of 200 students from Catatumbo and university student’s, both from the different semesters and documents curriculums. A mixed study of sequential explanatory design was applied. In the first quantitative phase, the results were obtained by applying a digital questionnaire to the students. The data were analyzed using the observation guide for their respective analysis. The results of both phases were merged by the contrasting method. The conclusions demonstrate the importance of curriculum for training in research and innovation and critical thinking, curriculum for the creation, adaptation and/or use of communication and information technologies, curriculum for social inclusion in the university.
Development of geometric thought
Authors: Pérez H J Gallardo , Ortega M Vergel , Gallardo O A Alvarado 
Published: October 2019

AbstractGeometric thinking is a process in which competences are developed to understand three-dimensional space. The experience arises from the need to implement teaching methodologies that allow to optimize both the potential of teachable that has the geometry as the potential of learnability of the student with the purpose of deepening in the learnings so that, by means of the construction of models and the mathematical principle of reconstruction and invention of mathematics, emphasizing spatial thinking and leading the student to recognize geometric objects, geometric spaces and associated transformations to develop mathematical skills while strengthening their geometric thinking.
Pedagogical guidelines for the development of competences that strengthen the teaching practices of the mathematics area
Authors: Silva M Conde , Suárez M K Villalba , Pérez H J Gallardo 
Published: October 2019

AbstractThe present study is aimed at promoting the use of pedagogical guidelines to strengthen the practice of the teacher of mathematics, through the use of specific competences of the area, in this sense the present research focuses on what happened in the process of teaching mathematics from pedagogical approaches proposed by the “Ministerio de Educación Nacional”, Colombia, as a result, it is proposed as a general objective to promote the use of pedagogical guidelines based on the Singapore model to enhance the teaching of mathematical skills, in order to be able to face the challenges of new educational spaces thought as transforming elements of the educational reality. On the other hand, this research is contextualized in the educational institutions “Lucio Pabón” in Ocaña and “Confanorte” in Los Patios, Norte de Santander, Colombia, to achieve such purposes, a qualitative ethnographic methodology was used, and field since it intends to interact with the object of study and its incidence in reality. For this, three teachers from the area of mathematics in each institution were selected, considered as key informants, since they will be in charge of supplying the diagnostic information and, from there, emphasizing the qualitative method using triangulation as the main method of analysis, from which emerged some categories that ensured the need to transform the praxis of the teacher, for this reason a proposal based on the Singapore method and on mathematical competences has been designed for the teachers of the indicated context.
Estimation of models and cycles in time series applying fractal geometry
Authors: Pérez H J Gallardo , Pérez O A Gallardo , Suárez J P Rojas 
Published: October 2019

Abstract
A time series, also called a time series or chronological series, consists of a set of data, coming from realizations of a random variable that are observed successively in time. Its analysis involves the use of statistical methods to adjust models to explain their behavior and make reliable forecasts. In this article integrated autoregressive models of moving average are adjusted to the studied series, complemented with specific methods of fractal geometry as support for the detection of the existence of random cycles in the series. The present investigation implies the realization of simulations, in a first phase and, later, the analysis of temporal series of economic and social variables of the country and the region.
The Educaplay interactive platform for the learning of mathematics in populations with special educational needs
Authors: Salazar L A Sánchez , Pérez H J Gallardo , Paz Montes L S 
Published: October 2019

Abstract
Mathematics, in populations with Special Educational Needs, must be worked from the context of the students and with problems that they can show leading them to apply the concepts and solutions to everyday life. In this context, the present study is based on the objective of implementing pedagogical strategies based on the use of the Educaplay interactive platform for the learning of mathematics in populations with special educational needs in the “Carmen Teresiano” school in the city of San José de Cúcuta, Colombia. From the theoretical point of view, it is based on humanist theory and the cognitive paradigm; on the other hand, it is based on the manual of the teacher of children with special educational needs of the “Ministerio de Educación”, Chile. Methodologically, it is a quasi-experimental study of pre- and post-test with only one group. The results of the pretest reflect deficiencies in the use of basic mathematical contents in the target population, which allowed for the design and implementation of an intervention plan and then to reapply, under the same conditions, the post-test. This resulted in an increase in the execution of the questions posed, which demonstrates the effectiveness of the intervention plan.
Assessing present and future coastal moderation of extreme heat in the Eastern United States
Authors: Raymond Colin , Mankin Justin S 
Published: October 2019

Abstract
Climate models suggest a rapid increase of extremely hot days in coming decades. Cool marine air currently ventilates extreme heat in populous coastal regions, diminishing its impacts, but how well climate models capture this effect is uncertain. Here we conduct a comprehensive observational analysis of coastal extreme-heat ventilation—its length scale, magnitude, and regional patterns—and evaluate two ensembles of downscaled global climate models along the eastern US coast. We find that coastal areas are 2 °C–4 °C cooler than ∼60 km inland, resulting in reductions near 50% in population exposure to temperatures above 35 °C. Large seasonal and inter-regional variations are closely linked with land-sea temperature contrasts. High-resolution models underestimate coastal cooling by 50%–75%, implying that substantial and spatiotemporally varying model bias correction is necessary to create accurate projections of coastal extreme heat, which is expected to rise considerably with anthropogenic forcing. Our results underline the importance of regionally- and observationally-based perspectives for assessing future extreme heat and its impacts, and for positioning effective heat-risk management for communities and jurisdictions that span coast-to-inland areas.
Identifying the complex types of atmosphere-ocean interactions in El Niño
Authors: Song Wan-Jiao , Yu Jin-Yi 
Published: October 2019

Abstract
A technique is developed to identify the types of atmosphere-ocean interaction during El Niño-Southern Oscillation events using sea surface temperature, sea level pressure (SLP), and outgoing longwave radiation (OLR) data. Two pairs of indices are derived that separate the interactions into tropical and subtropical types and basin-wide and local types. The dominant interaction type for the observed El Niño events since 1980 is identified and shown to shift with time from the tropical to subtropical and from basin-wide to local. Thus, the 21st century El Niños have become dominated by subtropical and local interactions, in strong contrast to the 20th century El Niños that were dominated by the tropical and basin-wide interactions. These changes result in the 1997–98 and 2015–16 extreme El Niños being different in their evolutions and global impacts, despite having similar intensities. SLP is the key variable for separating the tropical and subtropical types of interactions, while OLR is the key variable for separating the basin-wide and local types of interactions.
Structural diversity as a predictor of ecosystem function
Authors: LaRue Elizabeth A , Hardiman Brady S , Elliott Jessica M , Fei Songlin 
Published: October 2019

Abstract
Biodiversity is believed to be closely related to ecosystem functions. However, the ability of existing biodiversity measures, such as species richness and phylogenetic diversity, to predict ecosystem functions remains elusive. Here, we propose a new vector of diversity metrics, structural diversity, which directly incorporates niche space in measuring ecosystem structure. We hypothesize that structural diversity will provide better predictive ability of key ecosystem functions than traditional biodiversity measures. Using the new lidar-derived canopy structural diversity metrics on 19 National Ecological Observation Network forested sites across the USA, we show that structural diversity is a better predictor of key ecosystem functions, such as productivity, energy, and nutrient dynamics than existing biodiversity measures (i.e. species richness and phylogenetic diversity). Similar to existing biodiversity measures, we found that the relationships between structural diversity and ecosystem functions are sensitive to environmental context. Our study indicates that structural diversity may be as good or a better predictor of ecosystem functions than species richness and phylogenetic diversity.