bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do stock prices deviate from their fundamental values during and after COVID-19? Evidence from Fintech firms
Authors: Ali Salma , Ali Heba , Tarek Amira 
Published: December 2024

Purpose
This study aims at investigating the nexus between stock misvaluation, Fintech and COVID-19 via identifying the firm-level misvaluation of Fintech firms, and additionally examining how the COVID-19 pandemic has affected this misvaluation. This study further examines how the level of stock misvaluation has changed after the COVID-19 pandemic to shed more light on the pricing behavior of Fintech in a post-pandemic world.

Design/methodology/approach
The sample consists of all Fintech firms listed in the STOXX Global Fintech Index over the period (2014–2023). To empirically identify stock misvaluation, the authors apply the widely used approach of Rhodes-Kroph et al. (2005). Then, a series of fixed-effects regressions is conducted to investigate the impact of the COVID-19 pandemic on mispricing.

Findings
This study finds compelling evidence that Fintech stocks tend to be particularly mispriced during the COVID-19 pandemic. This evidence suggests that investors became more attracted to Fintech stocks, as being exposed to widespread adoption, usage and investment worldwide during the pandemic. Interestingly, the findings show that Fintech firms remain overvalued, even after the pandemic, which indicates that investors maintain their positive expectations for Fintech firms after the COVID-19 pandemic.

Practical implications
For investors and fund managers, the observed high valuation in the Fintech sector highlights its noticeable growth in the financial industry. The results also suggest that the impact of the COVID-19 pandemic on pricing behavior is asymmetric across the undervalued and overvalued Fintech stocks. This finding provides important insights for portfolio construction and investment strategies during the hard times of pandemics.

Originality/value
No previous work has been done on the effects of the COVID-19 pandemic on the prevailing levels of mispricing in Fintech stocks. Moreover, the findings provide novel insights into the pricing efficiency in the context of Fintech and extend the understanding of the long-term effects on Fintech firms in a post-pandemic world.
School staff perspectives on using augmentative and alternative communication with students with severe or profound intellectual and multiple disabilities
Authors: Flink Anna Rensfeldt , Wallin Sofia , Larsson Johanna , Westling Ellen , Johnels Jakob Åsberg 
Published: December 2024

AbstractThis mixed methods survey study aims to investigate school staff's perspectives on using augmentative and alternative communication (AAC) with students with the most severe disabilities in Swedish school settings. The study employed a convergent mixed methods design, where both quantitative and qualitative data were collected and analysed in parallel and then integrated and compared in the discussion and conclusion section of the paper. The study's respondents consisted of school staff who worked with students with severe or profound intellectual and multiple disabilities (S/PIMD) in Swedish schools. Results showed that almost all staff reported using AAC with students at least half of the time. The frequency of AAC use did not seem to differ between staff with different educational backgrounds, apart from teachers/special educators appearing slightly more inclined to use AAC in planned classroom activities when compared to staff with other educational backgrounds. The results also corroborate previous research stating that collaboration between stakeholders (such as school, family and the habilitation services) is fundamental to successful AAC implementation but that there are challenges when establishing efficient collaborations between stakeholders.
Patient care on the ramp: Who is legally responsible?
Authors: Eburn Michael , Cockburn Tina , Kelly Anne‐Maree 
Published: December 2024

AbstractAmbulance ramping, the delay to transfer of a patient arriving at an ED by ambulance into an ED treatment space and handover of care to ED clinicians, is a problem in all Australian states and territories and New Zealand. It is a symptom of ED overcrowding and access block and has been associated with adverse health outcomes for some patient groups. The questions arise, who might be legally responsible for the care of patients who are ramped and does their physical location matter? The short answers are ‘everyone' and ‘no', however, whether there will be a breach of duty depends on the reasonableness of responses and resource allocation considerations.
Establishing trust in emergency telehealth consultations
Authors: Hutton Jennie , Michael Veal , Miller Suzanne M , Baines Belinda , Kirjanenko Marija , Sher Loren , Lawrence Joanna , Boyd James , Semciw Adam , Jessup Rebecca , Talevski Jason 
Published: December 2024

AbstractOver recent years, emergency telehealth has developed rapidly in Australasia. From the patient's perspective, establishing trust with a healthcare provider is uniquely challenging when using the audio and video modalities commonly used in telehealth. It is crucial to consider how we may improve the delivery of care through this emerging pathway if high‐quality care is to be delivered. Several simple techniques have been identified in the literature and can be employed to create trust and improve the patient–provider relationship. These include ensuring privacy and an appropriate setting for the consultation; considering how eye contact and expressions are best used; providing alternative options to telehealth; and clearly identifying names, roles and qualifications. We describe how these methods can best be employed in the virtual emergency care setting.
Identifying the impact of water constraints on agricultural productivity in hillside contexts
Authors: Dizon Felipe , Imtiaz Muhammad Saad , Yu Jisang 
Published: December 2024

AbstractUsing a unique panel dataset based on two census rounds, we estimate the impact of irrigation gaps and drought on yields of paddy, maize, and other crops in Bhutan, an understudied country. We utilize a recently‐developed spatial first differences (SFD) approach to identify the impacts of water‐related constraints and compare these results from a panel fixed effects (FE) approach. We find that irrigation gaps reduce paddy yields and droughts reduce maize yields. Estimates from the SFD model are found to be consistent compared to those from the panel FE model. Water‐related constraints also reduce yields of vegetable crops, and other constraints such as labor shortages, wild animals, insects, and diseases reduce yields of cereal crops.
Successful Amendment of an Existing Hepatitis B Screening Programme by a Guideline Recommended Hepatitis D Screening in the Primary Care Setting
Authors: Herta Toni , Joachim‐Richter Anna , Petroff David , Wölk Benno , Wolffram Ingmar , Berg Thomas , Kramer Jan , Bätz Olaf , Wiegand Johannes 
Published: December 2024

ABSTRACTBackgroundDespite European guidelines recommending anti‐hepatitis D virus (HDV) screening for all hepatitis B surface antigen (HBsAg)‐positive cases, screening rates remain insufficient.AimsWe analysed anti‐HDV screening rates in primary care and implemented prospective HDV screening in HBsAg‐positive cases identified in the preventive medical examination from the age of 35 (“Check‐Up 35+”).MethodsFrom 2012 to 2021, we reviewed anti‐HDV and HDV RNA test rates in HBsAg‐positive patients at 11 sites of a large German laboratory group. From 2022 to 2023, we prospectively screened HBsAg‐positive samples from the “Check‐Up 35+” for anti‐HDV. Anti‐HDV positive patients were then contacted again for HDV RNA testing.ResultsRetrospectively, 2792/13,905 (20%) HBsAg‐positive cases were tested for anti‐HDV, with 142/2792 (5.1%) being positive. HDV RNA was tested in 57/142 (40%) anti‐HDV‐positive cases, with 26/57 (46%) being positive. In the prospective screening, 1159/225,901 (0.51%) individuals were HBsAg‐positive. Of these, 700 (60%) were tested for anti‐HDV, with 18/700 (2.6%) positive test results. 4/18 (22%) were successfully contacted again for HDV RNA analysis, with one case testing positive. Neither the HBsAg nor the anti‐HDV positive result was known prior to screening in these cases. Anti‐HDV testing could not be performed in 459/1159 (40%) HBsAg‐positive cases, primarily due to insufficient blood sample volume (310/459 cases, 68%), with others missed due to logistical errors.ConclusionsRetrospective data show insufficient anti‐HDV screening in clinical routine. The prospective anti‐HDV screening provides a blueprint for using existing hepatitis B virus screening programms for population‐based HDV double reflex testing, provided that adequate logistical prerequisites are established.Trial RegistrationGerman Clinical Trial Register: DRKS00029180
No Association Between Eosinophilic Oesophagitis and Oesophageal Cancer in US Adults: A Case–Control Study
Authors: Albaneze Natasha , Cotton Cary C. , Anderson Chelsea , Katzka David A. , Dellon Evan S. 
Published: December 2024

ABSTRACTBackgroundWhile inflammation is implicated in the development of numerous cancers, whether eosinophilic oesophagitis (EoE) increases the risk of oesophageal cancer (OCa) remains understudied.AimTo assess whether adults with EoE were more likely to have subsequent OCa diagnosis.MethodsThis case–control study used data from the MarketScan commercial claims database. Cases were 18–64 years old with an oesophageal cancer diagnosis (≥ two coding instances) who had no previous oesophageal cancer code. Controls were matched 10:1 by age and time in health plan. All cases and controls had at least 2 years of continuous healthcare coverage before the index date. EoE status required ≥ two coding instances. We used conditional logistic regression modelling to assess the association between EoE and oesophageal cancer.ResultsOf 5562 eligible cases and 55,620 matched controls, median age was 58.8 years and median number of years in health plan was 5.1. The proportions of male cases and controls were 81.3% and 41.4%, respectively. A history of EoE was rare in both cases and controls. Only two oesophageal cancer cases (0.04%) and 44 controls (0.08%) had evidence of an EoE diagnosis (OR 0.46; 95% CI 0.11–1.88).ConclusionsEoE is not associated with the development of oesophageal cancer in privately insured adults under 65 years old; co‐incidence of EoE and oesophageal cancer is extremely rare. Additional studies are needed to confirm these findings and to evaluate whether they hold in older adults or over longer follow‐up, and whether EoE might protect against oesophageal cancer.
Genetic characteristics of the coronet scores related to Holstein cattle hoof health in Japan
Authors: Saito Yuriko , Nishiura Akiko , Yamazaki Takeshi , Yamaguchi Shigeki , Tatebayashi Ryoki , Sasaki Osamu , Satoh Masahiro 
Published: December 2024

AbstractHoof disorders are crucial factors leading to dairy cattle culling. These disorders are difficult to detect, diagnose, and record, causing animal health problems and serious economic losses. The coronet score is a new hoof health indicator developed by the Dairy Herd Improvement Program of Japan. This score is assigned on a 5‐point scale and can easily be determined by examining the degree of redness and swelling around the hooves. To determine whether coronet scores can be used to genetically improve hoof health, we investigated non‐genetic factors in the score, developed a genetic analysis model, and estimated genetic parameters. Coronet scores were collected from 1280 herds in 28 prefectures once a month from 2014 to 2021. Furthermore, 1,598,878 test‐day records of 94,951 cows from the first‐ to third‐parity and pedigree information of 216,416 individuals were used in the analysis. Results revealed that herd size, parity, age, test month, and lactation stage influenced the coronet score. Additionally, the heritability of the coronet score estimated via the herd‐test‐day model was 0.027, and genetic trends deteriorated in sires and cows. Overall, we demonstrated that coronet score is a heritable trait, suggesting that hoof health could be genetically improved by selection for coronet score.
Machine learning based on multiplatform tests assists in subtype classification of mature B‐cell neoplasms
Authors: Lin Junwei , Mu Yafei , Liu Lingling , Meng Yuhuan , Chen Tao , Fan Xijie , Yuan Jiecheng , Shen Maoting , Pan Jianhua , Ren Yuxia , Yu Shihui , Chen Yuxin 
Published: December 2024

SummaryMature B‐cell neoplasms (MBNs) are clonal proliferative diseases encompassing over 40 subtypes. The WHO classification (morphology, immunology, cytogenetics and molecular biology) provides comprehensive diagnostic understandings. However, MBN subtyping relies heavily on the expertise of clinicians and pathologists, and differences in clinical experience can lead to variations in subtyping efficiency and consistency. Additionally, due to the diversity in genetic backgrounds, machine learning (ML) models constructed based on Western populations may not be suitable for Chinese MBN patients. To construct a highly accurate classification model suitable for Chinese MBN patients, we first developed an ML model based on next‐generation sequencing (NGS) from Chinese MBN patients, with an accuracy of 0.719, which decreased to 0.707 after model feature selection. Another ML model based on NGS and tumour cell size had an accuracy of 0.715, which increased to 0.763 after model feature selection. Both models were more accurate than models constructed using Western MBN patient databases. Furthermore, by adding flow cytometry for CD5 and CD10, the accuracy reached 0.864, which further improved to 0.872 after model feature selection. These models are accessible via an open‐access website. Overall, ML models incorporating multiplatform tests can serve as practical auxiliary tools for MBN subtype classification.
The relationships among illness perceptions, dyadic coping and illness management in breast cancer patients and their spouses: A dyadic longitudinal mediation model
Authors: Li Mingfang , Zhang Lijuan , Zhang Liping , Li Xinyi , Xie Yantong , Qiu Yuqi , Zhao Meng , Chen Jing , Yan Jun 
Published: December 2024

AbstractObjectivesTo describe and compare dyads' illness perceptions, dyadic coping and illness management among breast cancer patients and their spouses. In addition, we explore the direct actor and partner effects of illness perception on illness management, and whether this association is mediated by dyadic coping.DesignA descriptive and longitudinal study.MethodsBaseline illness perceptions and dyadic coping during hospitalization were measured by using the Illness Perception Questionnaire–revised (IPQ‐R) and the Dyadic Coping Inventory (DCI). At the 3rd month after discharge, the Cancer Self‐Management Assessment Scale (CSMAS) and the Caregiver's Contribution to the Cancer Patient's Self‐Management Scale (CC‐CPSMS) were used to test the dyads' illness management. Then, the actor–partner interdependence mediation model (APIMeM) was constructed to explore intrapersonal and interpersonal effects.ResultsA total of 225 postsurgical breast cancer patients and their spouses completed the questionnaires. It revealed that patients' or spouses' illness perceptions had both positive and negative direct actor effects on their own illness management (positive: personal control and illness coherence dimension; and negative: timeline acute/chronic, consequence, emotional representation and causes‐uncontrollable factors dimension). The significant direct partner effects were only displayed in the timeline acute/chronic dimension. Moreover, dyadic coping had mediating effects on these paths, and only the actor–actor and partner–actor indirect effects were statistically significant.ConclusionsThis study demonstrates the significance of illness perceptions in influencing dyads' illness management and reveals the underlying mediating mechanism of dyadic coping. It can provide more specific guidance for dyadic interventions to optimize dyads' behaviour among breast cancer patients and their spouses.
TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate
Authors: Meng Michelle Y. , Paine Luke W. , Sagnat David , Bello Ivana , Oldroyd Sophie , Javid Farideh , Harper Matthew T. , Hockley James R. F. , St. John Smith Ewan , Owens Róisín M. , Alric Laurent , Buscail Etienne , Welsh Fraser , Vergnolle Nathalie , Bulmer David C. 
Published: December 2024

Background and PurposeAbdominal pain is a leading cause of morbidity for people living with gastrointestinal disease. Whereas the transient receptor potential vanilloid 4 (TRPV4) ion channel has been implicated in the pathogenesis of abdominal pain, the relative paucity of TRPV4 expression in colon‐projecting sensory neurons suggests that non‐neuronal cells may contribute to TRPV4‐mediated nociceptor stimulation.Experimental ApproachChanges in murine colonic afferent activity were examined using ex vivo electrophysiology in tissues with the gut mucosa present or removed. ATP and glutamate release were measured by bioluminescence assays from human colon organoid cultures and mouse colon. Dorsal root ganglion sensory neuron activity was evaluated by Ca2+ imaging when cultured alone or co‐cultured with colonic mucosa.Key ResultsBath application of TRPV4 agonist GSK1016790A elicited a robust increase in murine colonic afferent activity, which was abolished by removing the gut mucosa. GSK1016790A promoted ATP and glutamate release from human colon organoid cultures and mouse colon. Inhibition of ATP degradation in mouse colon enhanced the afferent response to GSK1016790A. Pretreatment with purinoceptor or glutamate receptor antagonists attenuated and abolished the response to GSK1016790A when given alone or in combination, respectively. Sensory neurons co‐cultured with colonic mucosal cells produced a marked increase in intracellular Ca2+ to GSK1016790A compared with neurons cultured alone.Conclusion and ImplicationsOur data indicate that mucosal release of ATP and glutamate is responsible for the stimulation of colonic afferents following TRPV4 activation. These findings highlight an opportunity to target the gut mucosa for the development of new visceral analgesics.
The paracetamol metabolite N‐acetyl‐4‐benzoquinoneimine (NAPQI) prevents modulation of KV7 channels via G‐protein coupled receptors by interference with PIP2 and Ca2+ sensitivity
Authors: Losgott Thomas , Kudlacek Oliver , Yang Jae‐Won , Schicker Klaus W. , Boehm Stefan , Salzer Isabella 
Published: December 2024

Background and PurposeParacetamol has been found to alleviate inflammatory pain by modulating KV7 channels. Its metabolite N‐acetyl‐4‐benzoquinoneimine (NAPQI) increases currents through these channels via a stretch of three cysteine residues in the channel S2–S3 linker. Through this effect, the excitability of neurons in the pain pathway is dampened. Inflammatory mediators, in turn, enhance the excitability of sensory neurons by inhibiting KV7 channels. Here, a specific interaction between NAPQI and the so‐called inflammatory soup was investigated.Experimental ApproachCurrents through KV7 channels were measured in sensory neurons and after heterologous expression in tsA201 cells. In addition, changes in cytosolic Ca2+ and in the distribution of PIP2 (PI(4,5)P2) between membrane and cytosol were determined by fluorescence microscopy.Key ResultsNAPQI abolished Ca2+‐mediated inhibitory effects of an ‘inflammatory soup’ containing ADP, ATP, bradykinin, histamine, 5‐hydroxytryptamine, prostaglandin E2, substance P and a PAR2 agonist on KV7 channel currents in sensory neurons. Moreover, the increase of KV7.2 channel currents by quenching of cytosolic Ca2+ as well as the current decrease by depletion of membrane PIP2 was impaired by NAPQI. These effects were lost in mutant channels lacking the three cysteines in the S2–S3 linker.Conclusion and ImplicationNAPQI targets the three‐cysteine motif in the S2–S3 linker of KV7.2 channels to counteract the signalling cascades employed by inflammatory mediators that inhibit these channels. In sensory neurons, this abolishes the closure of KV7 channels by the inflammatory soup. This mechanism is likely involved in the alleviation of inflammatory pain by paracetamol.
Instruments to Assess Transition Readiness Among Adolescents With Chronic Disease: A COSMIN Systematic Review of Measurement Properties
Authors: Yi Ting , Hu Yiwen , Xia Lin , Zhang Yao , Chen Xuewei , Dong Chaoqun 
Published: December 2024

ABSTRACTBackgroundTransition readiness is a key predictor of the success of the medical transition. There are numerous categories of assessment instruments for transition readiness in adolescents with chronic disease, but systematic integration and standardized evaluation of instruments are limited regarding measurement properties, complicating the selection of scientifically valid and reasonable instruments. This review aimed to critically appraise, compare, and summarize the transition readiness assessment instruments in adolescents with chronic diseases.MethodsA comprehensive search was conducted in 10 databases from their inception to September 3, 2023. The Consensus‐based Standards for Selection of Health Measurement Instruments (COSMIN) systematic review guideline was used to evaluate the quality of the Patient‐Reported Outcome Measures (PROMs) and to facilitate the recommendation of the most suitable measuring instruments.ResultsThe total number of retrieved articles was 1798, out of which 74 were selected for full‐text evaluation. Finally, a total of 41 articles were included, involving 22 transition readiness assessment instruments. Nine of the assessment instruments were generalized assessment instruments, whereas 13 were for specific chronic diseases. Because of insufficient or uncertain content validity and moderate or low quality of evidence, the 22 assessment instruments were recommended by grade B.ConclusionsThis systematic review offers a comprehensive overview of the measurement characteristics of the transition readiness assessment instrument for adolescent patients with chronic illnesses, along with corresponding recommendations. The findings indicate that no instrument demonstrated superior performance over others. Consequently, future efforts should focus on developing additional high‐quality instruments in accordance with COSMIN guidelines to evaluate transition readiness among this population precisely.
Effect of Loading Angles on Abutment Screw Loosening: In Vitro Study
Authors: Sun Fei , Xu Li‐Bing , Lin Zeng , Jiang Lu‐Lu 
Published: December 2024

ABSTRACTAimBiomechanical performance is a critical factor in the long‐term success of dental implants, with abutment screw loosening being a common clinical issue. This study aimed to examine the impact of abutment screw design and external load loading angles on abutment screw loosening.Materials and MethodsAbutments and abutment screws with 30°, 60°, 90°, and 180° fitting tapers were fabricated and tested for preload and initial loosening torque. Subsequently, dynamic loosening tests were conducted at loading angles of 15°, 30°, and 45°. Finite element analysis (FEA) was used to calculate the stress and strain distribution of the abutment screws.ResultsThe findings indicated that large‐taper abutment screws exhibit a higher preload, whereas small‐taper abutment screws demonstrate greater loosening torque values. Additionally, as the loading angle increases, the loosening torque value decreases, and the stress and strain values of the abutment screw increase.ConclusionsAbutment screws with smaller taper heads exhibited superior resistance to loosening. Moreover, the anti‐loosening performance of the abutment screws decreased with higher external load loading angles.