bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longterm Efficacy and Safety of Monotherapy versus Combination Therapy in Systemic Sclerosis–associated Pulmonary Arterial Hypertension: A Retrospective RESCLE Registry Study
Authors: Pestaña-Fernández Melani , Rubio-Rivas Manuel , Tolosa-Vilella Carles , Guillén-Del-Castillo Alfredo , Freire Mayka , Vargas-Hitos Jose Antonio , Todolí-Parra Jose Antonio , Rodríguez-Carballeira Mónica , Marín-Ballvé Adela , Espinosa Gerard , Colunga-Argüelles Dolores , Ortego-Centeno Norberto , Trapiella-Martínez Luis , Carbonell-Muñoz Cristina , Pla-Salas Xavier , Perales-Fraile Isabel , Corbella Xavier , Fonollosa-Pla Vicent , Simeón-Aznar Carmen Pilar 
Published: February 2019

Objective.Monotherapy is an option as first-line therapy for pulmonary arterial hypertension (PAH). However, combination therapy is a beneficial alternative. Our objective was to evaluate the efficacy of monotherapy versus combination therapy in patients with systemic sclerosis (SSc)–associated PAH.Methods.All patients with SSc-associated PAH from the Spanish Scleroderma Registry (RESCLE) were reviewed. Patients were split into 3 groups: monotherapy versus sequential combination versus upfront combination therapy. The primary endpoint was death from any cause at 1, 3, and 5 years from PAH diagnosis.Results.Seventy-six patients (4.2%) out of 1817 had SSc-related PAH. Thirty-four patients (45%) were receiving monotherapy [endothelin receptor antagonist (n = 22; 29%) or phosphodiesterase-5 inhibitors (n = 12; 16%)], 25 (33%) sequential combination, and 17 (22%) upfront combination therapy. A lower forced vital capacity/DLCO in the sequential combination group was reported (2.9 ± 1.1 vs 1.8 ± 0.4 vs 2.3 ± 0.8; p = 0.085) and also a higher mean pulmonary arterial pressure in combination groups (37.2 ± 8.7 mmHg vs 40.8 ± 8.8 vs 46 ± 15.9; p = 0.026) at baseline. Treatment regimen (p = 0.017) and functional class (p = 0.007) were found to be independent predictors of mortality. Sequential combination therapy was found to be an independent protective factor (HR 0.11, 95% CI 0.03–0.51; p = 0.004), while upfront combination therapy showed a trend (HR 0.68, 95% CI 0.23–1.97; p = 0.476). Survival from PAH diagnosis among monotherapy, sequential, and upfront combination groups was 78% versus 95.8% versus 94.1% at 1 year, 40.7% versus 81.5% versus 51.8% at 3 years, and 31.6% versus 56.5% versus 34.5% at 5 years (p = 0.007), respectively. Side effects were not significantly different among groups.Conclusion.Combination sequential therapy improved survival in our cohort.
Radiographic Progression Inhibition with Intravenous Golimumab in Psoriatic Arthritis: Week 24 Results of a Phase III, Randomized, Double-blind, Placebo-controlled Trial
Authors: Kavanaugh Arthur , Husni M. Elaine , Harrison Diane D. , Kim Lilianne , Lo Kim Hung , Noonan Lenore , Hsia Elizabeth C. 
Published: February 2019

Objective.Evaluate effects of intravenous (IV) golimumab (GOL) on radiographic progression in psoriatic arthritis (PsA).Methods.This phase III, randomized, double-blind, placebo-controlled trial (GO-VIBRANT) randomized patients with active PsA to receive IV placebo (n = 239) or IV GOL 2 mg/kg (n = 241) at weeks 0, 4, 12, and 20. Radiographic progression (controlled secondary endpoint) was evaluated as change from baseline at Week 24 in PsA-modified total Sharp/van der Heijde scores (SvdH). The proportions of patients with a change from baseline at Week 24 in the total PsA-modified SvdH exceeding the smallest detectable change (SDC) or > 0 or 0.5 also were determined.Results.Overall, 474 patients (237/arm) contributed radiographic data. Results obtained from the 2 blinded, independent radiographic readers demonstrated good agreement (total score intraclass correlation coefficients: baseline = 0.93, Week 24 = 0.92, Week 24 change score = 0.73). GOL demonstrated significant inhibition of radiographic progression relative to placebo from baseline to Week 24 (mean changes in PsA-modified total SvdH: −0.36 vs 1.95; treatment difference: −2.32; p < 0.001). At Week 24, smaller proportions of GOL- versus placebo-treated patients demonstrated an increase in the total PsA-modified SvdH score exceeding the SDC (8.0% vs 27.0%, respectively; difference: −19.0%; p < 0.001), > 0 (28.3% vs 57.0%, respectively; difference: −28.7%; p < 0.001), or > 0.5 (18.6% vs 41.8%, respectively; difference: −23.2%; p < 0.001). Results were consistent for erosion and joint space narrowing scores, in hands and feet, and in patients with/without baseline concomitant methotrexate use. Prevention of radiographic progression by GOL was independent of clinical response.Conclusion.IV GOL is significantly better than placebo in inhibiting radiographic progression of structural damage in active PsA. [Clinical trial registration number (www.ClinicalTrials.gov): NCT02181673]
OMERACT Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS) Assessment in Longitudinal Study
Authors: Jaremko Jacob L. , Lambert Robert G.W. , Pedersen Susanne J. , Weber Ulrich , Lindsay Duncan , Al-Ani Zeid , Steer Kieran , Pianta Marcus , Wichuk Stephanie , Maksymowych Walter P. 
Published: February 2019

Objective.To assess reliability, feasibility, and responsiveness of Hip Inflammation Magnetic resonance imaging Scoring System (HIMRISS) for bone marrow lesions (BML) in hip osteoarthritis (OA).Methods.HIMRISS was scored by 8 readers in 360 hips of 90 patients imaged pre/post-hip steroid injection. Pre-scoring, new readers trained online to achieve intraclass correlation coefficient (ICC) > 0.80 versus experts.Results.HIMRISS reliability was excellent for BML status (ICC 0.83–0.92). Despite small changes post-injection, reliability of BML change scores was high in femur (0.76–0.81) and moderate in acetabulum (0.42–0.56).Conclusion.HIMRISS should be a priority for further assessment of hip BML in OA, and evaluated for use in other arthropathies.
OMERACT 2018 Modified Patient-reported Outcome Domain Core Set in the Life Impact Area for Adult Idiopathic Inflammatory Myopathies
Authors: Regardt Malin , Mecoli Christopher A. , Park Jin Kyun , de Groot Ingrid , Sarver Catherine , Needham Merrilee , de Visser Marianne , Shea Beverly , Bingham Clifton O. , Lundberg Ingrid E. , Song Yeong W. , Christopher-Stine Lisa , Alexanderson Helene 
Published: February 2019

Objective.To present and vote on a myositis modified patient-reported outcome core domain set in the life impact area at the Outcome Measures in Rheumatology (OMERACT) 2018.Methods.Based on results from international focus groups and Delphi surveys, a draft core set was developed.Results.Domains muscle symptoms, fatigue, level of physical activity, and pain reached ≥ 70% consensus and were mandatory to assess in all trials. Domains lung, joint, and skin symptoms were mandatory in specific circumstances. This core set was endorsed by > 85% at OMERACT 2018.Conclusion.We propose a life impact core set for patients with idiopathic inflammatory myopathies and will proceed with instrument selections.
Advancing Stiffness Measurement in Rheumatic Disease: Report from the Stiffness Special Interest Group at OMERACT 2018
Authors: Craig Ethan T. , Orbai Ana-Maria , Mackie Sarah , Bartlett Susan J. , Bingham Clifton O. , Goodman Susan , Hill Catherine , Holt Robert , Leong Amye , Karyekar Chetan , Leung Ying Ying , Richards Pamela , Halls Serena 
Published: February 2019

Objective.To improve measurement of stiffness in rheumatic disease.Methods.Data presented included (1) 2 qualitative projects, (2) the rheumatoid arthritis (RA) stiffness patient-reported outcome measure (RAST), and (3) 3 items assessing stiffness severity, duration, and interference.Results.Stiffness is multidimensional and includes aspects of stiffness experience such as duration, severity, and effect. Stiffness items showed construct validity in RA. Further efforts are required to develop an instrument that will be taken through the Outcome Measures in Rheumatology (OMERACT) Filter 2.1 for instrument selection.Conclusion.The research agenda for the group includes domain content voting for individual diseases, and development of stiffness item banks and disease-specific short forms.
Imaging of Epiretinal Membranes Using En Face Widefield Swept-Source Optical Coherence Tomography
Authors: Motulsky Elie , Zheng Fang , Shi Yingying , Garcia José M. B. , Gregori Giovanni , Rosenfeld Philip J. 
Published: February 2019

BACKGROUND AND OBJECTIVE:
Swept-source optical coherence tomography (SS-OCT) imaging was performed on eyes with epiretinal membranes (ERMs), and the extent of the ERMs were compared between the 12 mm × 12 mm scans and the more routine 6 mm × 6 mm field of view (FOV).

PATIENTS AND METHODS:
Eyes containing ERMs were imaged using a 12 mm × 12 mm SS-OCT scan. En face images derived from vitreoretinal interface (VRI) slabs were reviewed to assess the full extent of the ERM.

RESULTS:
En face VRI slab images from 12 mm × 12 mm scans could visualize the full extent in eyes with ERMs.

CONCLUSIONS:
The use of 12 mm × 12 mm SS-OCT scans and en face VRI slabs provided better visualization of large ERMs compared with a 6 mm × 6 mm FOV. This strategy can be useful in identifying the full extent of tractional forces and may help with preoperative surgical planning in selected cases.

[
Ophthalmic Surg Lasers Imaging Retina.
2019;50:106–112.]
De la terreur à la pitié : les anticipations de Marcel Schwob et de Paul Adam
Authors: Staron Anita 
Published: February 2019

« La Terreur future » de Marcel Schwob et Le Conte futur de Paul Adam, tous deux écrits au début de la dernière décennie du XIXe siècle, reflètent le climat agité de ces années en racontant des conflits situés dans un avenir plus ou moins vague. Sans négliger les différences entre les deux textes, notre analyse se concentre sur les éléments communs, possibles à relever dans la présentation de ces conflits. Il semble notamment que le principe fondateur du Cœur double se réalise aussi bien dans le conte de Schwob que dans celui d’Adam ; mais ce passage de la terreur à la pitié n’emprunte que partiellement le même chemin. Peut-on pour autant conclure à la portée optimiste des deux textes ? C’est également à cette question que la présente étude tâche de répondre.
Un roman d’alerte : 1962 en 1922. Berbéropolis... l’an quarante de la République berbère par Victor Trenga (Alger, 1922)
Authors: Chaulet Achour Christiane 
Published: February 2019

FrDans la littérature coloniale française sur l’Algérie, il n’existe que deux romans d’anticipation. Cet article s’intéresse à celui de Victor Trenga, Berbéropolis – Tableaux de la vie nord-africaine en l’an quarante de la République berbère, édité en 1922 et qui prédit l’avènement d’une République berbère... en 1962 ! Notre étude montre que, dans le contexte de l’époque, ce roman d’alerte se dresse contre la politique d’assimilation de la France et contre ce qu’on a nommé « le mythe kabyle », pour que l’Algérie reste une possession française.république berbère, Orient de pacotille, pamphlet, islam, Algérie française
Cité modèle et Cité guerrière : utopie et dystopie dans Les Cinq cents millions de la Bégum de Jules Verne
Authors: Hubner Patrick 
Published: February 2019

Il s’agit d’une réflexion autour du motif de la guerre présente et future sur le mode de l’uchronie selon un schéma habituel dans les romans de Jules Verne. Les Cinq cents millions de la Bégum correspondent dans la fiction à l’héritage miraculeux d’une grand-tante éloignée, ladite Bégum, épouse en secondes noces d’un lointain parent commun aux deux héros selon une généalogie fictive. L’héritage fabuleux se trouve partagé entre deux ennemis, parents par le hasard d’un autre mariage : d’une part Herr Schultze, professeur allemand passionné de chimie, d’autre part François Sarrasin, docteur français préoccupé par les problèmes de santé et d’hygiène. Et c’est à l’occasion d’un Congrès international d’Hygiène à Londres en 1871 que le docteur français lance le projet philanthropique d’une Cité modèle. L’histoire, comme intrigue romanesque, est une transposition de l’Histoire, du conflit franco-prussien, sous forme d’une uchronie projetée vers la marge nord-ouest des États-Unis, une utopie située géographiquement mais en une sorte de non-lieu produit par l’éloignement. Dans la fiction, l’héritier allemand riposte en annonçant au même Congrès devoir fonder une Place forte, Stahlstadt, la Cité de l’Acier. Mais cette dialectique manichéenne structurant le roman serait faussée par une absence, cette fonction vacante révélée par le chaos du conflit entre la Cité de l’Acier et ladite Cité de la Paix.
L’étude de la violence dans le Sur Racine de Roland Barthes
Authors: Zarzouli Despina 
Published: February 2019

Le Sur Racine de Roland Barthes a rencontré un succès sans précédent et une diffusion qu’aucun livre de critique n’a connue au XXe siècle. Barthes, en une célèbre polémique, y qualifie Racine de « degré zéro de l’objet critique », métaphore qui reflète ses interrogations personnelles au sujet des auteurs dits « classiques » du XVIIe siècle. Malgré toutes les polémiques que le Sur Racine a pu susciter, cette étude représente, selon les mots mêmes de l’auteur, « une sorte d’anthropologie structurale et analytique ». Cet article vise à analyser la violence telle que le Sur Racine de Roland Barthes la pense. D’après l’auteur, le théâtre de Racine serait un théâtre de la violence et, pour lui, l’antagonisme, l’injustice, la colère, la terreur, l’indignation..., constituent des éléments étroitement liés à la notion de violence. On essaiera de démontrer ici que l’analyse de ces éléments s’avère pertinente pour l’ensemble de l’œuvre de Racine.
Precision of continuous GPS velocities from statistical analysis of synthetic time series
Authors: Masson Christine , Mazzotti Stephane , Vernant Philippe 
Published: February 2019

Abstract. We use statistical analyses of synthetic position time series to estimate the
potential precision of GPS (Global Positioning System) velocities. The
synthetic series represent the standard range of noise, seasonal, and
position offset characteristics, leaving aside extreme values. This analysis
is combined with a new simple method for automatic offset detection that
allows an automatic treatment of the massive dataset. Colored noise and the
presence of offsets are the primary contributor to velocity variability.
However, regression tree analyses show that the main factors controlling the
velocity precision are first the duration of the series, second the presence
of offsets, and third the noise level (dispersion and spectral index). Our
analysis allows us to propose guidelines, which can be applied to actual GPS
data, that constrain velocity precisions, characterized as a 95 %
confidence limit of the velocity biases, based on simple parameters:
(1) series durations over 8.0 years result in low-velocity biases in the
horizontal (0.2 mm yr−1) and vertical (0.5 mm yr−1) components;
(2) series durations of less than 4.5 years are not suitable for studies that
require precisions lower than mm yr−1; (3) series of intermediate
durations (4.5–8.0 years) are associated with an intermediate horizontal
bias (0.6 mm yr−1) and a high vertical one (1.3 mm yr−1),
unless they comprise no offset. Our results suggest that very long series
durations (over 15–20 years) do not ensure a significantly lower bias
compared to series of 8–10 years, due to the noise amplitude following a
power-law dependency on the frequency. Thus, better characterizations of
long-period GPS noise and pluri-annual environmental loads are critical to
further improve GPS velocity precisions.
Structure and Function of Pulmonary Surfactant Proteins
Authors: García‐Álvarez Begoña , Alonso Alejandro , Pérez‐Gil Jesús 
Published: February 2019

Abstract

Pulmonary surfactant is a lipid/protein complex essential to keep the airspaces of mammalian lungs open. It forms surface‐active films at the respiratory air–liquid interface, reducing surface tension to a minimum and thus minimising the work of breathing. At the same time, surfactant establishes the first barrier against the entry of potential pathogens through the large surface that lungs expose to environment. Both the interfacial and the innate defence activities depend critically on the presence of highly specialised evolutionarily conserved surfactant‐associated proteins. The structure and molecular mechanisms of these proteins have been extensively characterised in the last decades, in studies that constitute the basis for current models on surfactant mechanisms at the alveolar spaces, in health and disease. This article summarises the current knowledge on the structure–function relationships defining the molecular action of pulmonary surfactant proteins and how they are being key actors to maintain operative breathing in the lungs.

Key Concepts

The presence of specific proteins is essential for pulmonary surfactant to play its crucial role in stabilising the respiratory air–liquid interface.

Collectin proteins SP‐A and SP‐D oligomerise to form trimers and supratrimeric oligomers with multivalent binding capacities to sugars and lipids and participate in innate defence mechanisms, binding to the surface of pathogens and allergens to facilitate their clearance.

Surfactant protein SP‐B is essential for life; its absence is associated with an irreversible respiratory failure at birth.

SP‐B belongs to the saposin protein family and assembles as ring‐shaped oligomers that enclose hydrophobic channels competent to transfer phospholipids between membranes and between membranes and the interface, avoiding its exposure to aqueous environments.

Some synthetic peptides designed to mimic key SP‐B motifs are being used to produce alternative surfactant preparations for therapeutic applications.

Protein SP‐C is a very hydrophobic helical protein whose expression is linked to the differentiation of lung tissue. Its oligomerisation is associated with surfactant membrane fragmentation and their interconversions at the alveolar spaces.
Reproductive Parasitism and Positive Fitness Effects of Heritable Microbes
Authors: Drew Georgia C , Frost Crystal L , Hurst Gregory DD 
Published: February 2019

Abstract

The classification of host–symbiont relationships is usually defined along the parasitism‐mutualism spectrum. It has long been proposed that transmission route is a key factor driving this, with vertical transmission leading to mutualism and horizontal transmission leading to parasitism. However, uniparental vertical transmission can lead to the evolution of reproductive parasitism, whereby host reproduction is skewed to increase the proportion of females within a population or else to reduce the comparative fitness of uninfected females (to the detriment of overall host fitness). Once discussed separately from beneficial effects and mutualism, we now recognise reproductive parasitism is not exclusive of other symbiont phenotypes. We outline the evolution and relationship of reproductive parasitism with respect to positive fitness effects for hosts, and how these interactions may be dynamic across the parasitism‐mutualism continuum.

Key Concepts

Exclusive maternal transmission of microbes can create strong selection for reproductive parasitism.

Heritable microbes are also selected to confer a range of positive effects on host function and physiology.

Where heritable microbes act both as reproductive parasites, and as a positive influence on host function, they are referred to as Jekyll and Hyde symbionts.

The presence of positive effects on host function can facilitate the invasion and maintenance of reproductive parasites in host populations.

Reproductive parasitism may likewise provide a context in which symbionts may evolve host‐beneficial phenotypes.

Symbionts that combine reproductive parasitism with positive effects on host function constitute a useful mechanism for modification of insect host biology in natural populations, coupling a strong gene drive system to a beneficial trait.

The presence of multiple phenotypes may aid the spread of heritable microbes through host communities, by enabling host shift events.

Lateral transfer of genetic information between microbes can provide the mutational mechanism through which Jekyll and Hyde symbionts arise.
Adaptive finite‐time actuator fault‐tolerant coordinated attitude control of multispacecraft with input saturation
Authors: Zhu Zhihao , Guo Yu , Gao Zhi 
Published: February 2019

SummaryIn this study, for nonrigid spacecraft formation, a distributed adaptive finite‐time actuator fault‐tolerant (FTAFT) coordinated attitude tracking control (CATC) issue is addressed. Aiming at stabilizing the spacecraft formation flying system during a limited time, two distributed adaptive FTAFT CATC strategies are presented. Initially, on basis of distributed finite‐time observer (DFTO), adaptive control, consensus approach, graph theory, and finite‐time theory, we develop a distributed adaptive FTAFT coordinated attitude tracking controller to repress the impact of the external state‐dependent and state‐independent disturbance, unknown time‐varying inertia uncertainty, and actuator fading or fault. Then, combining with the proposed controller, a distributed adaptive FTAFT control law with input saturation subjected to physical limitations of actuator is further designed. In addition, a self‐adjusting matrix (SAM) is proposed to improve the actuators' performance. With the two proposed CATC strategies, the followers can synchronize with the leader. Simulations demonstrated the validity of the designed control laws.
Engineered Smart Gating Nanochannels for High Performance in Formaldehyde Detection and Removal
Authors: Wu Kai , Kong Xiang‐Yu , Xiao Kai , Wei Yan , Zhu Congcong , Zhou Ru , Si Mengting , Wang Jijiang , Zhang Yuqi , Wen Liping 
Published: February 2019

AbstractBioinspired nanochannels for smart mass transport control have shown great potential for various applications in nanofluids, biosensing, and separation. Here, a nanochannel‐based smart responsive platform exhibiting high formaldehyde (HCHO) sensitivity is designed and successfully fabricated by functionalizing the inner pore surface with ethylenediamine (EDA). By employing the nucleophilic addition reaction between HCHO and EDA immobilized on the nanochannels, the artificial nanochannels can switch from an open state to a closed state with the increase in HCHO. This is because the surface charge density and the wettability of the nanochannels change along with the HCHO immobilization. Meanwhile, the EDA‐functionalized platform can hold a large amount of HCHO due to the abundant nanochannels of the membrane, so it presents a significant ability to remove HCHO in complex matrices. Also, the cultivation of mesenchymal stem cells in media containing HCHO can achieve excellent vitality in the presence of the EDA‐functionalized nanochannels materials. This work paves an avenue for designing and developing bioinspired nanochannel based platform for harmful compounds detection and removal.