bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of serum interleukin 17 and zinc levels in recalcitrant viral wart
Authors: Ghanem Afaf Helmy , Esawy Abdulla Mohamed , Khalifa Naglaa Ali , Kamal Hend Mahmoud 
Published: August 2019

AbstractBackgroundWarts are benign epithelial proliferations of the skin and mucosa caused by infection with HPV. Low IL‐17 levels may contribute in occurrence, maintenance, severity, and recurrence of different types of cutaneous wart that depend mainly on the cell‐mediated immunity defect. In a majority of the patients, zinc deficiency was associated with persistent, progressive, or recurrent viral warts. A careful dose of oral zinc sulfate may be helpful in the management of such patients. Zn deficiency negatively affects the Th17 cells. IL 6 induced STAT3 activation during chronic inflammation and Th17 development suppressed by Zn via attenuating this activation critically controls Th17‐cell development.ObjectivesTo evaluate the role of interleukin 17 and zinc in recalcitrant warts.Patents and methodsAll studied patients were subjected to history taking and dermatological examination. The evaluation of serum IL‐17 level was done by ELISA in 25 recalcitrant wart patients and 25 wart patients. The measurement of serum zinc level was determined by colorimetric methods, using Au 480 Beckman coulter chemistry analyzer.ResultsThe results revealed a significant decrease in serum IL‐17 and zinc levels in recalcitrant wart patients.ConclusionBoth IL‐17 and zinc deficiency have a role in the pathogenesis of recalcitrant warts through the imbalance of immune system and deficiency of immune cells. There is no significant correlation between serum levels of IL‐17 and zinc, suggesting that they have different mechanisms in affecting the immune system.
Clinical indicators of nursing outcomes classification for patient with risk for perioperative positioning injury: A cohort study
Authors: Bjorklund‐Lima Luciana , Müller‐Staub Maria , Cardozo Michelle Cardoso e , de Souza Bernardes Daniela , Rabelo‐Silva Eneida Rejane 
Published: August 2019

AbstractAims and objectivesTo test the validity and reliability of Nursing Outcomes Classification outcomes and their clinical indicators for patients with the nursing diagnosis ‘Risk for perioperative positioning injury’.BackgroundSurgical positioning is an essential part of perioperative nursing practice. The use of a standardised language values the clinical evaluation of the perioperative nurse, reinforcing its contribution to surgical patient care.DesignLongitudinal concept validation cohort study.MethodsPatients were selected based on the operating room surgical schedule. The sample included adult patients who underwent elective surgical procedures requiring anaesthesia, classified as surgical class 2, 3 or 4. Outcomes were measured with an instrument, which included 33 clinical indicators for eight outcomes. The patients were assessed at five distinct time points in the perioperative phases. This study followed the STROBE guidelines.ResultsA total of 50 patients were included. Each underwent five clinical assessments, for a total of 250 documented assessments. Differences in evaluations were mostly related to reduced scores of clinical indicators in the immediate postsurgical time points, which recovered to the highest score at the end of the fifth (and last) evaluation. The results of factor analysis and Cronbach's alpha calculations suggested a new configuration for this nursing outcomes, consisting of five outcomes—Circulation Status, Tissue Perfusion: peripheral, Neurological Status: peripheral, Tissue Integrity: skin and mucous membranes and Thermoregulation—and 13 clinical indicators.ConclusionsNursing Outcomes Classification outcomes and clinical indicators for the nursing diagnosis at ‘Risk for perioperative positioning injury’ are sensitive to patient states during the perioperative period.Relevance to clinical practiceUse of nursing taxonomies during the perioperative period may contribute to the discussion on the role of perioperative nurses and their relevance in patient care.
Construction of an index system for qualitative evaluation of undergraduate nursing students innovative ability: A Delphi study
Authors: Dai Fengling , Wei Kunyan , Chen Yanhua , Ju Mei 
Published: August 2019

AbstractAim and objectiveTo establish an index system for the evaluation of undergraduate nursing student innovation ability.BackgroundAn index system for evaluation of undergraduate nursing student innovation ability has not been established.DesignA three‐round Delphi survey sought opinions from experts about the index system for evaluation of undergraduate nursing student innovation ability.MethodsA Delphi survey was used for the study of 19 experts from nursing education, clinical nursing and health management. The consistency of consultation results formed the basis for determining the rounds of consultation. With the importance of consulting experts in the last round, we established the judgement matrix usingyaahp7.5software and the analytic hierarchy process and determined the weight coefficient of each index. A modified recommendation for the Conducting and Reporting of Delphi studies (CREDES) was used to guide this study.ResultsNineteen experts from 10 nursing colleges and nine third‐level first‐class hospitals in seven domestic provinces/municipalities were included in this study. The index system was divided into primary, secondary and tertiary levels. Consensus was reached on three primary indicators (‘spirit’, ‘ability’ and ‘achievement’), nine secondary indicators and 28 tertiary indicators.ConclusionsA unified and hierarchical quality assessment index framework for nursing undergraduate creative ability was established. The framework should be further tested and improved in practice.Relevance to clinical practiceNursing students are the main force behind clinical nursing in the future. An innovative approach to skill acquisition and application could enhance the student nurse experience. The innovative ability of nursing students is important for identification of education strategies that be implemented to better support those individuals. Furthermore, the construction of the index system is helpful for evaluation of the innovation ability of nursing students that are required to better meet the needs of clinical nursing work in the future.
The effectiveness of hypnotic analgesia in the management of procedural pain in minimally invasive procedures: A systematic review and meta‐analysis
Authors: Noergaard Marianne Wetendorff , Håkonsen Sasja Jul , Bjerrum Merete , Pedersen Preben U. 
Published: August 2019

AbstractIntroductionPatients undergoing minimally invasive procedures under a light conscious sedation perceive pain and anxiety. Hypnosis used together with analgesics has been investigated in numerous studies.Aims and methodsTo assess the effectiveness of hypnotic analgesia in management of pain, anxiety, analgesic consumption, procedure length and adverse events in adults undergoing minimally invasive procedures. Clinical controlled trials in which hypnosis was used together with pharmacological analgesia compared to pharmacological analgesia alone during invasive procedures were included. Seven databases were searched. The methodological quality of the studies was assessed by two reviewers using a standardised instrument for critical appraisal from Joanna Briggs Institute, ‘Meta‐Analysis of statistics assessment and review Instrument’. Meta‐analyses using the review manager version 5.3 software were conducted on procedure length and adverse events. Results for pain, anxiety and analgesics were synthesised in narrative summaries. Conduction of the review adheres to the PRISMA checklist.ResultsTen studies comprising 1,365 participants were included. A reduction in the consumption of pain medication was found between 21%–86% without aggravating pain intensity and anxiety. In few studies, significant reduction in pain intensity and anxiety was found. Meta‐analysis including seven studies revealed a small beneficial effect on reducing procedure length. A meta‐analysis on adverse events showed no significant reduction. Statistical heterogeneity was found among the studies included.ConclusionFor patients undergoing invasive procedures, hypnotic analgesia was effective in reducing consumption of analgesics. Only a slight effect was, however, found on experienced anxiety and pain intensity. It did not prolong the procedure and was safe to provide.Relevance to clinical practiceHypnosis is recommended as pain management for adults during invasive procedures. A reduced consumption of pain medication potentially has a major impact on monitoring and observation of patients following the procedure, thus improving patient safety and reducing resource consumption.
Midwives' use of best available evidence in practice: An integrative review
Authors: De Leo Annemarie , Bayes Sara , Geraghty Sadie , Butt Janice 
Published: August 2019

AbstractAims and objectivesTo synthesise international research that relates to midwives' use of best available evidence in practice settings and identify key issues relating to the translation of latest evidence into everyday maternity care.BackgroundMidwifery is a research‐informed profession. However, a gap persists in the translation of best available evidence into practice settings, compromising gold standard maternity care and delaying the translation of new knowledge into everyday practice.DesignA five‐step integrative review approach, based on a series of articles published by the Joanna Briggs Institute (JBI) for conducting systematic reviews, was used to facilitate development of a search strategy, selection criteria and quality appraisal process, and the extraction and synthesis of data to inform an integrative review.MethodsThe databases CINAHL, MEDLINE, Web of Science, Implementation Science Journal and Scopus were searched for relevant articles. The screening and quality appraisal process complied with the PRISMA 2009 checklist. Narrative analysis was used to develop sub‐categories and dimensions from the data, which were then synthesised to form two major categories that together answer the review question.ResultsThe six articles reviewed report on midwives' use of best available evidence in Australia, the UK and Asia. Two major categories emerged that confirm that although midwifery values evidence‐based practice (EBP), evidence‐informed maternity care is not always employed in clinical settings. Additionally, closure of the evidence‐to‐practice gap in maternity care requires a multidimensional approach.ConclusionCollaborative partnerships between midwives and researchers are necessary to initiate strategies that support midwives' efforts to facilitate the timely movement of best available evidence into practice.Relevance to clinical practiceUnderstanding midwives' use of best available evidence in practice will direct future efforts towards the development of mechanisms that facilitate the timely uptake of latest evidence by all maternity care providers working in clinical settings.
The effect of knowledge and health beliefs about colorectal cancer on screening behaviour
Authors: Taş Ferdane , Kocaöz Semra , Çirpan Rabiye 
Published: August 2019

AbstractAims and objectivesTo determine the effect of the knowledge and health beliefs of individuals about colorectal cancer on their screening behaviour.BackgroundColorectal cancer ranks third among the most common cancers both worldwide and in Turkey. Colorectal cancer plays an important role in cancer mortality but can be prevented by promoting healthy behaviour and participation in early screening programmes.DesignThis descriptive study was completed with 114 women and 121 men.MethodsThe study data were collected using the ‘Data collection form' and ‘Health Belief Model Scale for Protection from Colorectal Cancer'. Potential risk factors were investigated using logistic regression analyses. The AGREE checklist was completed.ResultsThe colorectal cancer screening tests were known by 23.0% of the subjects and 17% had undergone one of these tests. The score medians obtained from the confidence‐benefit subscale of Health Belief Model Scale for Protection from Colorectal Cancer were found to be significantly higher in those who had undergone colorectal cancer screening. Logistic regression analysis revealed that having knowledge of the relevant tests was associated with undergoing colorectal cancer screening.ConclusionsHaving knowledge on colorectal cancer screening tests increases the relevant confidence‐benefit perception regarding the tests and the behaviour of participating in screening programmes. Regular training on colorectal cancer and early diagnosis should therefore be provided by healthcare professionals to both women and men aged 50–70 years to increase the rate of undergoing early screening tests.Relevance to clinical practiceIncreasing the rate of early screening is among the responsibilities of health workers working in primary health centres. Therefore, problems that prevent individuals from participating in these programmes need to be identified. In this way, health workers will develop suggestions and initiatives that change the individual's health beliefs and increase motivation.
Catheter dwell time and risk of catheter failure in adult patients with peripheral venous catheters
Authors: Wei Tao , Li Xu‐ying , Yue Zhi‐ping , Chen Yong‐yi , Wang Yi‐ren , Yuan Zhong , Lin Qin , Tan Yan , Peng Si‐yi , Li Xing‐feng 
Published: August 2019

AbstractAims and objectivesTo explore whether the risk of peripheral venous catheters failure remained constant throughout catheter use in adult patients.BackgroundPeripheral venous catheters, widely used in adult patients, may have a critical threshold dwell time associated with increased risk of catheter failure.DesignProspective, observational study. We have complied with the STROBE checklist of items.MethodsThis study was conducted from July–October 2018 in Hunan, China. Data on patient factors, catheter factors and catheter failure events were collected. Poisson regression was used to assess the effect of catheter dwell time on catheter failure while adjusting for other variables.ResultsA total of 1,477 patients were included in the analysis. There were 854 cases (57.8%) of catheter failure. The median dwell time to catheter failure was 52 hr (interquartile range: 36–73 hr). The incidence rate of catheter failure significantly increased by 1.1%/h in the first 38 hr after catheter insertion. From 39–149 hr, the incidence rate significantly decreased, and at >149 hr, there was no significant change in the incidence rate. Meanwhile, factors such as vascular quality and infused drugs showed having an impact on catheter failure events.ConclusionsThe risk of catheter failure may not remain constant throughout the dwell time. The results suggest that nurses should assess the insertion site frequently in the first 38 hr.Relevance to clinical practiceThe significant increase in the risk of catheter failure per hour may warrant close and frequent inspection of insertion site during the first 38 hr.
BRCA mutation frequency and clinical features of ovarian cancer patients: A report from a Chinese study group
Authors: Bu Hualei , Chen Jingying , Li Qingshui , Hou Jianqing , Wei Yuan , Yang Xiaohang , Ma Yana , He Hongsheng , Zhang Youzhong , Kong Beihua 
Published: August 2019

AbstractAimSubjects with germline BRCA1/2 mutations (gBRCAm) have an increased risk of developing breast cancer and ovarian cancer. At present, knowledge of BRCA1/2 mutation frequency in Chinese patients with ovarian cancer is still insufficient, and the detailed clinical information of these patients is poorly understood.MethodsA total of 547 unselected ovarian cancer patients were enrolled, and their gBRCAm status was detected. Clinical characteristics including age, personal and family history, histopathologic diagnosis, carbohydrate antigen 125 (CA‐125) level, ascites, Federation International of Gynecology and Obstetrics (FIGO) stage, residual lesions, platinum sensitivity, recurrence interval and survival information were collected. Accurate assessments of disease response were based on the RECIST standard or CA‐125 level.ResultsIn 547 patients with ovarian cancer, we detected 129 (23.6%) patients with pathogenic mutations, 84 patients with BRCA1 mutations (15.4%) and 45 patients with BRCA2 mutations (8.2%). Twenty‐five novel mutations were identified, and the mutation of BRCA1, c.5470_5477del8, was the most common mutation in this study. BRCA1/2 mutations were significantly associated with age; personal and family history; FIGO stage; secondary recurrence interval; sensitivity to platinum in 1st, 2nd and 3rd line treatment; and response to doxorubicin liposomes. Patients with BRCA1/2 mutations showed significant advantages in 3‐ and 5‐year survival rates but no advantage in long‐term survival.ConclusionBRCA1/2 mutation prevalence in Chinese ovarian cancer patients is higher than the international rate. We recommend BRCA1/2 testing for patients with family histories and personal histories of malignancy and genetic counseling for cancer in healthy people with high‐risk family histories.
Immunohistochemical expression of CD44v9 and 8‐OHdG in ovarian endometrioma and the benign endometriotic lesions adjacent to clear cell carcinoma
Authors: Niiro Emiko , Kawahara Naoki , Yamada Yuki , Yoshimoto Chiharu , Shimada Keiji , Sudo Tamotsu , Kobayashi Hiroshi 
Published: August 2019

AbstractAimExpression of CD44 variant isoforms (CD44v) promotes the synthesis of reduced glutathione and contributes to reactive oxygen species defense through up‐regulation of the intracellular antioxidant. The aim of the study was to investigate the expression of CD44v9 and oxidative DNA damage marker, 8‐OHdG, in benign ovarian endometrioma (OE) and OE harboring clear cell carcinomas (CCC).MethodsA retrospective study was performed at the Department of Gynecology, Nara Medical University hospital from January 2006 to December 2012. Patients with histologically confirmed benign OE (n = 27) and OE harboring areas of CCC (n = 8) were selected. Tissue samples were immunohistochemically analyzed for the presence of CD44v9 and 8‐OHdG using avidin‐biotin complex method.ResultsCD44v9 was located on the cell membrane of endometriotic epithelial cells and expressed in 88.9% (24/27) of benign OE tissues. Only 25.0% (2/8) of benign endometriotic lesions adjacent to CCC was found to stain weakly for CD44v9. Percentage of CD44v9 positive cells was 68.5 ± 20.2% (mean ± standard deviation) of benign OE, 16.7 ± 16.5% of CCC endometriotic tissue (P < 0.001). Compared to benign OE, CCC endometriotic tissue showed a significant increase in the proportion of 8‐OHdG expression (77.3 ± 22.5% vs 94.9 ± 3.0%, P = 0.049). A significant negative correlation was observed between CD44v9 status and 8‐OHdG nuclear expression (r = −0.458, P  =  0.006).ConclusionAlterations in CD44v9 and 8‐OHdG may be associated with malignant transformation of benign OE.
Changes in serum hepcidin levels in children with inflammatory bowel disease during anti‐inflammatory treatment
Authors: Karaskova Eva , Volejnikova Jana , Holub Dusan , Velganova‐Veghova Maria , Spenerova Michaela , Mihal Vladimir , Pospisilova Dagmar 
Published: August 2019

AimThe aim of this study was to compare changes in serum hepcidin levels in paediatric patients with inflammatory bowel disease during therapy and correlate them with markers of iron metabolism, inflammation and type of treatment.MethodsChildren with newly diagnosed Crohn's disease (CD) and ulcerative colitis (UC) were included in this longitudinal study. Blood and stool samples were collected to assess levels of serum hepcidin and markers of iron metabolism parameters and inflammation. The parameters were examined before treatment (baseline levels) and compared with levels in the follow‐up period during maintenance therapy (mean follow‐up of 39 months after diagnosis).ResultsPatients with CD (n = 30) had higher serum hepcidin levels (expressed as a median and interquartile range) at diagnosis than subjects with UC (n = 13). These levels significantly decreased during the follow‐up (from 36.5 (11.5–79.6) to 2.1 (0.9–6.7) ng/mL). In contrast, no significant serum hepcidin level changes were observed in the UC patients (5.4 (3.4–16.6) vs. 4.8 (0.9–8.1) ng/mL). While hepcidin level changes correlated with disease activity and inflammatory parameters (erythrocyte sedimentation rate, C‐reactive protein), in CD patients, they correlated only with serum iron levels in patients with UC. Biological therapy was accompanied by a significant decrease in C‐reactive protein and interleukin‐6 compared to conventional anti‐inflammatory therapy in CD patients.ConclusionsChildren with CD had higher serum hepcidin levels on diagnosis compared to subjects with UC. During an anti‐inflammatory therapy, serum hepcidin decreased in the CD group but remained consistently low in children with UC.
Lessons to be learned: Using National Immunisation strategies to improve adherence to acute rheumatic fever secondary prophylaxis
Authors: Liaw Joshua Y , White Andrew V , Gorton Susan , Axford‐Haines Louise 
Published: August 2019

AbstractRheumatic heart disease, as a result of a single or recurrent episode of acute rheumatic fever (ARF), remains a significant cause of morbidity and mortality in northern and remote Australia; ARF has a peak incidence among 5–14‐year‐old Aboriginal and Torres Strait Islander children. Long‐term regular benzathine penicillin G injections are the only currently successful secondary prevention strategy; however, rates of adherence remain critically low. In contrast, rates of adherence to immunisations on the National Immunisation Program (NIP) Schedule are high, even among this target population. This article compares strategies used to implement and improve ARF secondary prophylaxis with those used in the NIP. Some successful NIP strategies, such as Service Incentive Payment for health providers, home‐visiting delivery models and integration into the National Immunisation Register, if applied to ARF secondary prophylaxis have the potential to improve benzathine penicillin G adherence.