bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools
Authors: Kholodar Svetlana A. , Ghosh Ananda K. , Świderek Katarzyna , Moliner Vicent , Kohen Amnon 
Published: September 2018

Significance
Thymidylate synthase (TSase) is one of the prime anticancer targets, as it generates the sole de novo source of thymidylate, a unique precursor for DNA. Fluoropyrimidines and antifolates inhibiting TSase pathways are not only components of the most widely used therapeutic regimens but also highly toxic agents leading to acquired resistance in tumor cells. To provide fresh mechanistic insight to TSase-targeted drug design, we used a combination of experiments, kinetic modeling, and quantum mechanics/molecular mechanics (QM/MM) calculations to discover formation of unexpected noncovalent intermediates prevailing in the catalysis and overstabilized covalent species corresponding to a parallel reaction pathway. These findings challenge the traditional chemical path of this enzyme and offer drug targets.
A new clade of basal Early Cretaceous pygostylian birds and developmental plasticity of the avian shoulder girdle
Authors: Wang Min , Stidham Thomas A. , Zhou Zhonghe 
Published: September 2018

SignificanceWe report the second most basal clade of the short-tailed birds (Pygostylia) from the Early Cretaceous. The new family Jinguofortisidae exhibits a mosaic assembly of plesiomorphic nonavian theropod characteristics, particularly of the fused scapulocoracoid and more derived flight-related features, further increasing the known ecomorphological diversity of basal avian lineages. We discuss the evolution of the scapula and coracoid in major tetrapod groups and early birds and hypothesize that the fused scapulocoracoid in some basal avian lineages, although rare, results from an accelerated rate of ossification and that the avian shoulder girdle likely was transformed by developmental plasticity along an evolutionary lineage leading to the crown group of birds.
Class and Class Struggle
Authors: Heller Henry 
Published: September 2018

Abstract
This chapter affirms that class and class struggle were fundamental to Marx’s conception of history. His claims are affirmed as it is shown that upper-class demands for surplus and lower-class resistance have driven the evolution of society from the Bronze Age to the present and were critical to the passage from the tributary mode of production to the capitalist mode of production. Class struggle exists in all class-based societies but was particularly acute in China and the West. In Classical Antiquity class antagonism mainly took the form of peasant/landlord struggle but also expressed itself in conflict between slave and master. In modern times the bourgeoisie engaged in a two-sided struggle against both the landlord class and against the working class. Its struggle against the latter is ongoing. The state, culture, and ideology are key components of class struggle.
Aging Processes in the Subcortical Auditory System
Authors: Caspary Donald M. , Llano Daniel A. 
Published: September 2018

Abstract
As arguably the third most common malady of industrialized populations, age-related hearing loss is associated with social isolation and depression in a subset of the population that will approach 25% by 2050. Development of behavioral or pharmacotherapeutic approaches to prevent or delay the onset of age-related hearing loss and mitigate the impact of hearing loss of speech understanding requires a better understanding of age-related changes that occur in the central auditory processor. This chapter critically reviews and discusses changes that occur in the auditory brainstem and thalamus with increased age. It briefly discusses age-related cellular changes that occur de novo within the central auditory system versus deafferentation plasticity and animal models of aging. Subsections discuss the cochlear nucleus, superior olivary complex, inferior colliculus, and the medial geniculate body with an emphasis on age-related changes in neurotransmission and how these changes could underpin the observed loss of precise temporal processing with increased age.
Kenotic Ecumenism
Authors: Jillions John A. 
Published: September 2018

Abstract
This chapter considers the methodology of ecumenism from an Eastern Orthodox perspective. It begins by briefly reviewing the Holy and Great Council that took place in Crete in 2016, and its document on the relations of the Orthodox Church with the rest of the Christian world. The second part looks at the lukewarm or hostile reception of ecumenical dialogue, and the third examines more closely the debates for and against. The chapter then suggests ways to move Christian unity forward through a broader engagement of bishops; reconsidering the bold twentieth-century proposals of Sergius Bulgakov, Nicolas Afanasiev, and Nicholas Zernov; a ‘kenotic ecumenism’ based on Philippians 2:4–7 and the thought of John Zizioulas; and making communion with God the focus of a renewed ecumenical movement in which the Jesus Prayer could play an important unifying role.
Biologic Drugs as Analgesics for the Management of Low Back Pain and Sciatica
Authors: Dimitroulas Theodoros , Lambe Tosin , Raphael Jon H , Kitas George D , Duarte Rui V 
Published: September 2018

Abstract

Objective
To discuss the current knowledge on the impact of commonly used biologic agents (i.e., anti–tumor necrosis factor–alpha [anti-TNF-α] and anti–nerve growth factor [anti-NGF]) in the management of low back pain with or without sciatica.

Methods
A narrative literature review of studies investigating the use of biologic agents for the management of low back pain and sciatica was conducted. We searched MEDLINE and EMBASE for English language publications. A hand-search of reference lists of relevant studies was also performed.

Results
Although some observational studies showed that inhibition of TNF-α reduced pain and improved function, randomized controlled trials and a meta-analysis failed to demonstrate the superiority of anti-TNF-α over placebo in this regard. Anti-TNF-α, however, reduced the risk of having invasive procedures such as discectomy and radicular block in cases of sciatica. Conversely, controlled studies showed moderate pain reduction and mild functional improvement with anti-NGF administration, but the side effect profile of anti-NGF was unfavorable compared with placebo.

Conclusions
Overall, anticytokine treatments have limited efficacy in patients with chronic low back pain with or without sciatica. However, larger and better-designed studies may need to be performed in specific patient subpopulations. Low back pain is particularly disabling in younger patients. This group therefore represents a potential target population for investigating the effectiveness of anticytokine therapies, especially where other pharmacological and nonpharmacological management strategies have failed.
Identifying and validating blood mRNA biomarkers for acute and chronic insufficient sleep in humans: a machine learning approach
Authors: Laing Emma E , Möller-Levet Carla S , Dijk Derk-Jan , Archer Simon N 
Published: September 2018

AbstractAcute and chronic insufficient sleep are associated with adverse health outcomes and risk of accidents. There is therefore a need for biomarkers to monitor sleep debt status. None are currently available. We applied elastic net and ridge regression to transcriptome samples collected in 36 healthy young adults during acute total sleep deprivation and following 1 week of either chronic insufficient (&lt;6 hr) or sufficient sleep (~8.6 hr) to identify panels of mRNA biomarkers of sleep debt status. The size of identified panels ranged from 9 to 74 biomarkers. Panel performance, assessed by leave-one-subject-out cross-validation and independent validation, varied between sleep debt conditions. Using between-subject assessments based on one blood sample, the accuracy of classifying “acute sleep loss” was 92%, but only 57% for classifying “chronic sleep insufficiency.” A reasonable accuracy for classifying “chronic sleep insufficiency” could only be achieved by a within-subject comparison of blood samples. Biomarkers for sleep debt status showed little overlap with previously identified biomarkers for circadian phase. Biomarkers for acute and chronic sleep loss also showed little overlap but were associated with common functions related to the cellular stress response, such as heat shock protein activity, the unfolded protein response, protein ubiquitination and endoplasmic reticulum-associated protein degradation, and apoptosis. This characteristic response of whole blood to sleep loss can further aid our understanding of how sleep insufficiencies negatively affect health. Further development of these novel biomarkers for research and clinical practice requires validation in other protocols and age groups.
Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and cell migration
Authors: Bance Bertille , Seetharaman Shailaja , Leduc Cécile , Boëda Batiste , Etienne-Manneville Sandrine 
Published: September 2018

AbstractMicrotubules play a crucial role in mesenchymal migration by controlling cell polarity and the turnover of cell adhesive structures on the extracellular matrix. The polarized functions of microtubules imply that microtubules are locally regulated. Here, we investigated the regulation and role of two major tubulin post-translational modifications, acetylation and detyrosination, which have been associated with stable microtubules. Using primary astrocytes in a wound healing assay, we show that these tubulin modifications are independently regulated during cell polarization and differently affect cell migration. In contrast to microtubule detyrosination, αTAT1-mediated microtubule acetylation increases in the vicinity of focal adhesions and promotes cell migration. We further demonstrate that αTAT1 increases focal adhesion turnover by promoting Rab6-positive vesicle fusion at focal adhesions. Our results highlight the specificity of microtubule post-translational modifications and bring new insight into the regulatory functions of tubulin acetylation.
Subjective aspects in the thematic representation of photographic images
Authors: Torres Adriana Aparecida Lemos , Maculan Benildes C.M.S , Dias Célia da Consolação , Silva Gislene Rodrigues da 
Published: September 2018

Purpose
This paper aims to present the results of an analysis about the subjectivity in the process of thematic representation of photographs.

Design/methodology/approach
The experiments were applied to students of the Course of Librarianship (Biblioteconomia) of the Universidade Federal de Minas Gerais, during the discipline “thematic representation of images”. The methodology included two methods of analysis: in free form and using four methodologies: the methods of Panofsky (1979), Smit (1996), Shatford (1986) and Manini (2002).

Findings
The results showed that subjectivity is always present, even with the use of methodologies.

Research limitations/implications
This paper shows the importance of doing the librarian course and the need to improve and update their methods, standards, techniques and tools to provide subsidies for the normalization of subject analysis as an essential procedure for information retrieval.

Practical implications
It is concluded that thematic representation of images requires clear and detailed indexation policies that can systematize the activity and minimize the effects of the subjectivity involved.

Social implications
The determination of the subject of the document involves many factors. One of them is the cognition of the indexer, which is influenced by his prior knowledge, limitations and biases about the context. However, it must take into account, above all, the social reality of the user, as the main purpose of the representation is the retrieval of information.

Originality/value
This study contributes to reaffirm the importance of the indexing discipline in vocational training in librarianship courses, emphasizing the cognitive aspects to which the indexer will be subject.
Computational analysis of turbulent flow through an eccentric annulus under different temperature conditions
Authors: Ulker Erman , Korkut Sıla Ovgu , Sorgun Mehmet 
Published: September 2018

Purpose
The purpose of this paper is to solve Navier–Stokes equations including the effects of temperature and inner pipe rotation for fully developed turbulent flow in eccentric annuli by using finite difference scheme with fixing non-linear terms.

Design/methodology/approach
A mathematical model is proposed for fully developed turbulent flow including the effects of temperature and inner pipe rotation in eccentric annuli. Obtained equation is solved numerically via central difference approximation. In this process, the non-linear term is frozen. In so doing, the non-linear equation can be considered as a linear one.

Findings
The convergence analysis is studied before using the method to the proposed momentum equation. It reflects that the method approaches to the exact solution of the equation. The numerical solution of the mathematical model shows that pressure gradient can be predicted with a good accuracy when it is compared with experimental data collected from experiments conducted at Izmir Katip Celebi University Flow Loop.

Originality/value
The originality of this work is that Navier–Stokes equations including temperature and inner pipe rotation effects for fully developed turbulent flow in eccentric annuli are solved numerically by a finite difference method with frozen non-linear terms.
Technical issues and energy efficient adaptive reuse of heritage listed city halls in Queensland Australia
Authors: Yazdani Mehr Shabnam , Wilkinson Sara 
Published: September 2018

Purpose
Adaptive reuse of heritage stock has several advantages: retention of culturally and socially significant buildings, as well as the opportunity to consider embodied energy, energy efficiency retrofit measures and other environmental upgrades. The purpose of this paper is to identify the technical issues faced in the adaptive reuse of Australian heritage listed city halls and discuss sustainable strategies to enable further adaptations to be more energy efficient.

Design/methodology/approach
Adaptive reuse of a heritage building provides an opportunity to retain embodied energy, improve energy efficiency and enhance durability, which are important aspects of the technical lifecycle of a building. Using a case study methodology and a qualitative approach, this paper evaluates adaptations and the technical issues faced in three heritage city halls in Queensland, Australia.

Findings
The analysis shows that enhancing energy efficiency enables heritage buildings to reduce their climate change impacts. However, the installation of equipment for energy efficiency can pose technical issues for heritage buildings. The ownership of heritage building and interest of the local community affects the solutions that are viable. Solutions and further sustainable strategies are proposed through analysis of case studies.

Originality/value
City halls globally adopt different and varied architectural designs, features and scales. They are often heritage listed and locally significant landmarks that have undergone various adaptations; however, they have been overlooked in much adaptive reuse research, particularly in Australia. City halls differ from other heritage buildings in their collective sense of ownership which is important in regard to proposed changes, as citizens have an interest and hold opinions which may affect measures adopted. This paper contributes to the body of knowledge related to energy efficient technical adaptive reuse of city halls.
Wind power and real estate prices in Oklahoma
Authors: Castleberry Becca , Greene John Scott 
Published: September 2018

Purpose
Oklahoma has seen rapid growth in the development of wind energy over the past decade. Residents are concerned about the negative impacts of turbines such as noise or their appearance. This has raised concerns about property values. Thus, this paper aims to examine and quantify the overall impact of wind turbines upon real estate prices in Western Oklahoma.

Design/methodology/approach
Sales prices and the history of approximately 23,000 residential real estate records for both platted and unplatted properties in five counties were examined prior to the announcement of construction, after announcement and after construction. A hedonic analysis was undertaken to examine the real estate prices of the properties near wind farms.

Findings
While there may be isolated instances of lower property values for homes near wind turbines, results show no significant decreases in property values over homes near wind farms in the study area. Similar results are found for the unplatted properties.

Practical implications
This paper highlights that in spite of mixed attitudes toward wind farms and misconceptions regarding the link between turbines and property values, Oklahoma’s growing wind industry can continue to thrive without negatively impacting nearby home and land values and prices.

Originality/value
Although there have been numerous studies examining the relationship between wind turbine locations and real estate prices, no study has combined the large quantity of records (over 23,000) as well as both platted and unplatted locations.
Supporting process improvements with process mapping and system dynamics
Authors: Bowles David E. , Gardiner Lorraine R. 
Published: September 2018

Purpose
The purpose of this paper is to study the effectiveness of combining process mapping and system dynamics (SD) in an organization’s ongoing business process improvement projects.

Design/methodology/approach
Norfield Industries, designer and manufacturer of prehung door machinery, used process mapping and SD in a project targeting the improvement of its design document control process. The project team first used process mapping to document its current process and identify potential improvements. The team then developed an SD model to investigate the potential impacts of proposed process changes.

Findings
The case study supports the communication and transparency benefits of process mapping reported in earlier studies. Consistent with other case studies using simulation, SD provided useful insights into possible results of proposed process changes.

Research limitations/implications
The findings have limitations with respect to generalizability consistent with the use of a case study methodology.

Practical implications
Organizational managers desiring to include simulation modeling in process improvement efforts have a choice between discrete event simulation and SD. SD may prove able to consume less organizational resources than discrete-event simulation and provide similar benefits related to reducing the risks associated with process changes.

Originality/value
The current case study adds to the existing literature documenting the use of process mapping combined with simulation modeling in process improvement efforts. The case study supports existing literature regarding the value of process mapping in making system processes more transparent. The results also support previous findings regarding the value of SD for simulating the possible results associated with scenarios under consideration for process improvements.
International franchising and performance: a resource-based perspective
Authors: Ghantous Nabil , Das Shobha S. 
Published: September 2018

PurposeThe purpose of this paper is to investigate international franchise performance. It focuses on how franchisors conceive their international performance, the drivers of their international performance, and how age-at-entry moderates the impact of their resources and capabilities (R&C) on international performance.Design/methodology/approachUsing the lens of the resource-based view of the firm, the authors build on franchisor voice from a qualitative study (n=28) to propose a research model of international franchise performance. A second, quantitative study (n=89) tests the model with PLS structural equation modeling.FindingsFranchisors view international performance in terms of relationship satisfaction with foreign franchisees and performance in comparison to competitors. The empirical results show that relationship satisfaction significantly improves comparative performance. Both franchisor-owned resources, the brand and knowhow, enhance only comparative performance, while all three international relational capabilities, related to knowhow transfer, monitoring, and contract design, and both reconfigurational capabilities, related to organizational responsiveness and innovativeness, improve relationship satisfaction. Only contract design and innovativeness increase comparative performance. Finally, late internationalization reinforces franchisor ability to leverage relational and reconfigurational capabilities for better relationship satisfaction.Originality/valueThis paper contributes to research on international franchise performance. It uses a mixed-method design and offers the first quantitative investigation of the drivers of international franchise performance. This research also integrates the role of franchisor R&C with franchisor strategic choices, through the moderating effect of internationalization timing.
Moderating effects of marketing communication and financial consideration on customer attitude and intention to purchase Islamic banking products
Authors: Hoque Mohammad Enamul , Nik Hashim Nik Mohd Hazrul , Azmi Mohammad Hafizi Bin 
Published: September 2018

Purpose
The purpose of this paper is to introduce a conceptual framework that can facilitate investigations concerning the impact of marketing communication and financial consideration on the relationship between customer attitude and purchase intention of Islamic banking products and services.

Design/methodology/approach
This conceptual paper is structured based on the extant literature; it provides a review of theoretical perspectives, highlights the gap and illustrates the significance for developing a framework.

Findings
The authors identify notable patterns and limitations in previous empirical studies. Specifically, despite increasing interest in Islamic banking customer behavior, prior research has not given much attention to explore moderating effects on the customer attitude–intention link. This has left researchers and bank managers with very limited information to explain the conditions that enhance customers’ attitude and intentions toward Islamic banking products. Based on this backdrop, the paper displays a viable research model with propositions that assess potential moderating effects on the domain relationship.

Research limitations/implications
This paper contributes to Islamic banking and management literature because prior research has predominantly focused on variables that directly influence customers’ behavior. This novel conceptual framework enables managers to better understand their customers and has implications for emerging themes, such as formulating strategies for specific customer groups and internationalization process. In addition, this paper provides a starting point to empirically examine whether and how the proposed moderators affect the link between customer attitude and behavioral intentions to purchase Islamic banking products.

Originality/value
To the best of knowledge, this is the first attempt to introduce relevant moderating variables for investigating the attitude and intention nexus in an Islamic banking context. Furthermore, the authors propose a new measure, namely, profit-loss sharing proportions which could enhance customers’ intention to purchase Islamic banking products.