bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burden of hereditary transthyretin amyloidosis on quality of life
Authors: Yarlas Aaron , Gertz Morie A. , Dasgupta Noel R. , Obici Laura , Pollock Michael , Ackermann Elizabeth J. , Lovley Andrew , Kessler Asia Sikora , Patel Pankaj A. , White Michelle K. , Guthrie Spencer D. 
Published: May 2019

ABSTRACTIntroductionHereditary transthyretin (hATTR) amyloidosis is a progressive, degenerative disease, with peripheral neuropathy, cardiomyopathy, and other clinical manifestations. In this study we examine the impact of hATTR amyloidosis on quality of life (QOL).MethodsNeuropathy‐specific QOL, measured with the Norfolk QOL‐Diabetic Neuropathy questionnaire, was compared between patients with hATTR amyloidosis and patients with type 2 diabetes, whereas generic QOL, measured with the 36‐item Short Form Health Survey version 2 (SF‐36v2), was compared between patients with hATTR amyloidosis, the general population, and patients with chronic diseases.ResultsNeuropathy‐specific QOL for patients with hATTR amyloidosis was nearly equivalent to that of patients with type 2 diabetes with diabetic neuropathy accompanied by a history of ulceration, gangrene, or amputation. Generic QOL was worse than that seen in the general population, with physical functioning worse than that for patients with multiple sclerosis and congestive heart failure.DiscussionPatients with hATTR amyloidosis show significant burden on QOL, particularly in physical functioning. Muscle Nerve 60: 169–175, 2019
4‐Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice
Authors: Yue Li , Talukder M. A. , Gurjar Anagha , Lee Jung Il , Noble Mark , Dirksen Robert T. , Chakkalakal Joe , Elfar John C. 
Published: May 2019

ABSTRACTIntroductionWe recently demonstrated the beneficial effects of 4‐aminopyridine (4‐AP), a potassium channel blocker, in enhancing remyelination and recovery of nerve conduction velocity and motor function after sciatic nerve crush injury in mice. Although muscle atrophy occurs very rapidly after nerve injury, the effect of 4‐AP on muscle atrophy and intrinsic muscle contractile function is largely unknown.MethodsMice were assigned to sciatic nerve crush injury and no‐injury groups and were followed for 3, 7, and 14 days with/without 4‐AP or saline treatment. Morphological, functional, and transcriptional properties of skeletal muscle were assessed.ResultsIn addition to improving in vivo function, 4‐AP significantly reduced muscle atrophy with increased muscle fiber diameter and contractile force. Reduced muscle atrophy was associated with attenuated expression of atrophy‐related genes and increased expression of proliferating stem cells.DiscussionThese findings provide new insights into the potential therapeutic benefits of 4‐AP against nerve injury‐induced muscle atrophy and dysfunction. Muscle Nerve 60: 192–201, 2019
Exploring the utility of the Nursing Role Effectiveness Model in evaluating nursing contributions in primary health care: A scoping review
Authors: Lukewich Julia A. , Tranmer Joan E. , Kirkland Megan C. , Walsh Anna J. 
Published: May 2019

AbstractAimsTo inform a discussion for the applicability of using the Nursing Role Effectiveness Model (NREM) in the primary health care setting through a synthesis of the literature that has used the model in all health care sectors.DesignScoping Review.MethodsArticles were considered for inclusion if they discussed any aspect of the NREM in health care research that presented information related to any nursing regulatory designation, such as nurse practitioner (NP), registered nurse (RN), licensed/registered practical nurse (LPN/RPN) and considered both quantitative and qualitative study designs, including expert opinions and reports.ResultsA total of 22 articles that cited and/or used the NREM were identified in this review. Only two studies were focused in the primary health care setting. There is precedence for the use of the NREM to guide research in primary health care. The NREM should be modified to incorporate the unique characteristics of the primary health care setting.
Reflections on theories of market efficiency
Authors: Chhatwani Malvika Nandlal 
Published: May 2019

Market efficiency is determined by how efficiently markets capture the information. Efficient markets can capture and incorporate all the available information into stock prices within no time. It means market prices traded are the actual prices of shares. There have been many theories trying to debate about how to determine market efficiency. If markets are efficient, there is no scope for investors to earn abnormal returns on the investments. In that case, investments in markets would not provide any additional returns. There have been many debates and theories on the topic of market efficiency. Postmodern portfolio theory (PMPT) came into existence after almost 40 years of the modern theory of portfolio given by Henry Markowitz. Both the theories give a risk–return framework for decision making and there are many conflicting aspects of market efficiency. I try to address this issue in this paper that raises concerns for the investor as to which markets are called efficient and what contributes to market efficiency, as denoted in modern portfolio theory (MPT) and post modern portfolio theory (PMPT).
From latency to overt bone metastasis in breast cancer: potential for treatment and prevention
Authors: Salvador Fernando , Llorente Alicia , Gomis Roger R 
Published: May 2019

AbstractBone metastasis is present in a high percentage of breast cancer (BCa) patients with distant disease, especially in those with the estrogen receptor‐positive (ER+) subtype. Most cells that escape primary tumors are unable to establish metastatic lesions, which suggests that target organ microenvironments are hostile for tumor cells. This implies that BCa cells must achieve a process of speciation to adapt to the new conditions imposed in the new organ. Bone has unique characteristics that can be exploited by cancer cells: it undergoes constant remodeling and comprises diverse environments (including osteogenic, perivascular, and hematopoietic stem cell niches). This allows colonizing cells to take advantage of numerous adhesion molecules, matrix proteins, and soluble factors that facilitate homing, survival, and, eventually, metastatic outgrowth. However, in most cases, metastatic lesions enter into a latency state that can last months, years, or even decades, before forming a clinically detectable macrometastasis. This dormant state challenges the effectiveness of adjuvant chemotherapy. Detecting which tumors are more prone to metastasize to bone and developing new specific therapies that target bone metastasis represent urgent clinical needs. Here, we review the biological mechanisms of BCa bone metastasis and provide the latest options of treatments and predictive markers that are currently in clinical use or are being tested in clinical assays. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Fabrication and investigation of phosphoric acid doped imidazolium siloxane crosslinked poly(2,6‐dimethyl‐1,4‐phenylene oxide) for high temperature polymer electrolyte membranes
Authors: Ren Xiaorui , Li Huanhuan , Yang Jingshuai , Hao Zhe 
Published: May 2019

AbstractA series of high temperature polymer electrolyte membranes were fabricated based on imidazolium poly(2,6‐dimethyl‐1,4‐phenylene oxide) (PPO) using methylimidazole (MeIm) and triethoxysilylpropyldihydroimidazole (SiIm) as quaternization reagents via the SN2 nucleophilic substitution. Meanwhile SiIm was also employed as a crosslinking agent and the crosslinked Si–O–Si network was constructed through a hydrolysis procedure of SiIm in an acid medium. Compared with the PPO‐100%MeIm membrane without the crosslinking structure, the imidazolium siloxane crosslinked PPO‐x%SiIm‐y%MeIm membranes exhibited increased acid doping contents, enhanced dimensional stabilities, improved mechanical properties and higher conductivities. The PPO‐30%SiIm‐70%MeIm/(198 wt% phosphoric acid) membrane displayed a conductivity of 0.08 S cm−1 at 180 °C without humidifying and a tensile strength of 6.4 MPa at room temperature. © 2019 Society of Chemical Industry
PASS: A Proteomics Alternative Splicing Screening Pipeline
Authors: Wu Peng , Pu Lingling , Deng Bingnan , Li Yingying , Chen Zhaoli , Liu Weili 
Published: May 2019

AbstractAlternative splicing (AS) has been well‐investigated at the trancriptome level by the application of RNA‐seq technology. There is an ongoing debate on the biological importance of AS to proteome complexity. A toolkit for accurately identifying AS from proteome data is urgently needed. Here, a software called PASS is developed to comprehensively detect AS events for the proteomics mass spectrometry (MS) data. Moreover, PASS is well compatible with MS identification by the proteogenomics approach, which provides novel AS candidates for proteome identification. The workflow of PASS mainly contains five core steps: transcripts reconstruction from RNA‐Seq data, novel protein sequence generation, MS data searching, proSAM file formatting, and AS detection. Access to the program from either step is supported. PASS is successfully applied to proteome data of mouse hepatocytes and 407 AS events are first identified with proteomics MS evidences. PASS is expected to be widely used to identify AS events on proteome data and provide a deeper understanding of the proteome isoforms. The PASS software is freely available at https://github.com/wupengomics/PASS.
Identification of Serum Biomarkers for Ischemic Penumbra by iTRAQ‐Based Quantitative Proteomics Analysis
Authors: Pang Xiao‐Min , Zhou Xia , Su Sheng‐You , Chen Chun‐Yong , Wei Zhi‐Xiao , Tao Yi‐Feng , Liu Jing‐Li 
Published: May 2019

PurposeIschemic penumbra is the main therapeutic target for acute ischemic stroke. The aim in this study is to investigate the potential serum biomarkers of penumbra that could fulfill a complementary role in the acute stroke clinical decision‐making process.Experimental DesignAn established focal cerebral ischemia model is applied in rats. Using isobaric tags for relative and absolute quantitation combined with liquid chromatography‐tandem mass spectrometry, the global expression profiles of proteins in ischemic penumbra tissue and serum from rats subjected to different ischemic times are identified and quantified. Candidate biomarkers are screened out with bioinformatics analysis and further validated by western blotting.ResultsHerein, a total of 4568 proteins in the penumbra and 1915 proteins in the serum are identified. Two proteins related to the penumbra, RHOA, and CDC42, are screened out through an integrative analysis. The expression levels of RHOA and CDC42 in the penumbra and serum gradually increase synchronously with the prolonged ischemia time.Conclusions and Clinical RelevanceThe study provides the results of a proteomic analysis to identify serum biomarkers of the penumbra. Upregulation of RHOA and CDC42 may be useful for the early assessment of ischemic penumbra and could serve as potential serum biomarkers.
Milling of Energetic Crystals with the LabRAM
Authors: Kotter Lance N. , Groven Lori J. 
Published: May 2019

AbstractProcessing energetic materials with the LabRAM acoustic mixer has been widely published; however, using it as a vibratory mill has only recently been explored. The size reduction of energetic crystals remains a tremendous processing challenge as it is often time and energy intensive. The LabRAM has the potential to reduce the time and energy required for milling through the use of low frequency waves. In this study, three distinct materials were selected to determine the effects of milling with the LabRAM. Ammonium perchlorate (AP), sodium periodate (NaIO4), and nitroguanidine (NQ) were chosen as their starting crystal morphologies are spherical, irregular, and needle‐like, respectively. The three materials were analyzed by laser particle analysis and scanning electron microscopy (SEM) to determine the average particle size and any morphology changes that may occur while milling. The average particle size, D50, of the starting materials, AP, NaIO4, and NQ were 253 μm, 415 μm, and 60 μm, respectively. The D50 after only 15 minutes of continuous milling for AP, NaIO4, and NQ was 7.01 μm, 2.92 μm, and 22.90 μm, respectively. This study focuses on the feasibility of safely dry milling micron‐size energetic crystals on the LabRAM acoustic mixer, while optimizing milling parameters for effective size reduction.
Polycomb repressive 2 complex—Molecular mechanisms of function
Authors: Kouznetsova Valentina L. , Tchekanov Alex , Li Xiaoming , Yan Xiaowen , Tsigelny Igor F. 
Published: May 2019

AbstractNumerous molecular processes conduct epigenetic regulation of protein transcription to maintain cell specification. In this review, we discuss molecular mechanisms of the Polycomb group of proteins and its enzymatic role in epigenetics. More specifically, we focus on the Polycomb repressive complex 2 (PRC2) and the effects of its repressive marker. We have compiled information regarding the biological structure and how that impacts the stability of the complex. In addition, we examined functions of the individual core proteins of PRC2 in relation to the accessory proteins that interact with the complex. Lastly, we discuss the implications of unregulated and downregulated PRC2 activity in Alzheimer's disease and cancer and possible methods of treatment related to PRC2 regulation.
Zika virus: Molecular responses and tissue tropism in the mammalian host
Authors: Shaily Sangya , Upadhya Archana 
Published: May 2019

SummaryZika virus (ZIKV) outbreaks have raised alarm because of reports of congenital Zika virus syndrome in infants. The virus is also known to cause the debilitating Guillain–Barré syndrome in adults. As a result, extensive research has been carried out on the virus over the past few years. To study the molecular responses of viral infectivity in mammals, in vitro two‐dimensional and three‐dimensional cellular models have been employed. The in vivo models of mouse, pig, chicken, and nonhuman primates are primarily used to investigate the teratogenicity of the virus, to study effects of the virus on specific tissues, and to study the systemic effects of a proposed antiviral agent. The virus exhibits wide tissue tropism in the mammalian host. The major host tissues of viral persistence and propagation are neural tissue, ocular tissue, testicular tissue and placental tissue. An understanding of the function of viral components, viral replication cycle, and the molecular responses elicited in the host tissues is imperative for designing antiviral treatment strategies and for development of vaccines. This review provides an update on ZIKV research models and mammalian host responses with respect to ZIKV tissue infection.
A Facile Synthesis of Molybdenum‐Promoted Reduced Graphene Oxide as Catalyst towards Epoxidation of Cyclohexene
Authors: Rana Surjyakanta , Varadwaj G. Bishwa Bidita , Jonnalagadda Sreekantha B. 
Published: May 2019

AbstractA facile method by incipient wetness impregnation for synthesis of materials with different ratios of molybdenum (5/100), (10/100) and (15/100) promoted on reduced graphene oxide (RGO) is reported. Catalytic activity of the prepared materials towards liquid phase epoxidation of cyclohexene was investigated. The catalyst materials were fully characterized by varied techniques including XRD, FT‐IR, Raman spectra, and SEM analysis. The (10/100) metal to substrate ratio catalyst (Mo‐RGO‐2) showed excellent efficiency with 100% conversion of cyclohexene with 93% selectivity towards cyclohexene oxide. The catalyst exhibited good stability during recycling tests.
One pot multicomponent synthesis of Novel Bis‐N‐(1,2,3‐ triazolylacetyl) as Potent Antioxidant and Antibacterial Agents
Authors: Parvizi Jafar. , Mahmoodi Nosrat O. , Pirbasti Fateme. Ghanbari , Rassa Mehdi. 
Published: May 2019

AbstractA new series of bis‐triazoles has been synthesized through cycloaddition of prepared bis‐azides and diethyl acetylenedicarboxylate in the presence of CuCl2 under solvent‐free condition. Antioxidant activity of products at the concentration of 2000‐62.5 μg/mL using ABTS method was studied and products showed good antioxidant activity. Moreover, IC50 values of products were ranged from 2.00 to 0.06 mM and products 5f‐g and 5i possessed high antioxidant activity and lower IC50 values than ascorbic acid (vitamin C). Also, products 5g and 5e showed the lowest and highest antioxidant activities, respectively. Moreover, in vitro minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) of bis‐triazoles were screened against Gram‐positive bacteria strains including Micrococcus luteus and Staphylococcus Gram‐negative bacteria strains including Escherichia coli and Pseudomonas aeruginosa. Most of the products showed a lower MIC than penicillin against tested bacterial strains and also most of the products were active against negative bacterial strains.
Daisaikoto for shoulder stiffness and related changes in stool condition: Retrospective study
Authors: Ohsawa Minoru , Takayama Shin , Kikuchi Akiko , Arita Ryutaro , Saito Natsumi , Ikeno Yuka , Nishikawa Hitoshi , Sasaki Hiroyo , Kojima Michiyo , Shimizu Masayuki , Numata Takehiro , Ishizawa Kota , Ishii Tadashi 
Published: May 2019

ABSTRACTAimDaisaikoto has been used for the treatment of shoulder stiffness and abdominal distention with constipation, which makes stool changes associated with the prescription a concern. The aim of this retrospective observational study was to investigate the effect of daisaikoto on shoulder stiffness and the relation between its effects on stiffness relief and stool condition.MethodsWe reviewed the medical records of middle‐aged women who were treated with daisaikoto for menopause‐like symptoms and shoulder stiffness from December 2014 through November 2015 at Red Cross Maebashi Hospital. Two or 4 weeks after the prescription of daisaikoto, symptoms were evaluated and categorized as improved, no change, or worse. Stool condition was also evaluated and categorized as constipation, normal, or diarrhea. Change in symptoms from before to after treatment was analyzed using the Wilcoxon signed‐rank test. The relationship between symptom changes and stool condition was analyzed using Spearman's rank correlation coefficient.ResultsOf 24 patients who received daisaikoto, shoulder stiffness was relieved in 79% (P < 0.05). Diarrhea was reported in 8% of patients, all of whom were classified in the non‐improvement group, which included depressed patients. Improvement of shoulder stiffness and stool condition had a correlation coefficient of 0.542. Daisaikoto did not worsen stool condition in the patients in whom it was effective.ConclusionDaisaikoto effectively relieves shoulder stiffness in middle‐aged women, and did not worsen stool condition in those with improvement in shoulder stiffness. Daisaikoto without Rhubarb or other formulas may be an alternative treatment choice for diarrhea patients with shoulder stiffness.
Generic matter representations in 6D supergravity theories
Authors: Taylor Washington , Turner Andrew P. 
Published: May 2019

AbstractIn six-dimensional supergravity, there is a natural sense in which matter lying in certain representations of the gauge group is “generic,” in that other “exotic” matter representations require more fine tuning. From considerations of the dimensionality of the moduli space and anomaly cancellation conditions, we find that the generic sets of matter representations are well-defined for 6D supergravity theories with gauge groups containing arbitrary numbers of nonabelian factors and U(1) factors. These generic matter representations also match with those that arise in the most generic F-theory constructions, both in 6D and in 4D, with non-generic matter representations requiring more exotic singularity types. The analysis of generic versus exotic matter illuminates long-standing puzzles regarding F-theory models with multiple U(1) factors and provides a useful framework for analyzing the 6D “swampland” of apparently consistent low-energy theories that cannot be realized through known string constructions. We note also that the matter content of the standard model is generic by the criteria used here only if the global structure is SU(3)c× SU(2)L× U(1)Y/ℤ6.
Which is Better for Patients with Breast Cancer: Totally Implanted Vascular Access Devices (TIVAD) or Peripherally Inserted Central Catheter (PICC)?
Authors: Tang Tian‐tian , Liu Lei , Li Chun‐xiao , Li Yun‐tao , Zhou Tao , Li Hai‐ping , Wang Jianxin 
Published: May 2019

AbstractBackgroundOur aim was to compare the applications of totally implanted vascular access devices (TIVAD) and peripherally inserted central catheter (PICC) in breast cancer patients.MethodsWe analyzed 4080 cases of TIVAD and 1433 cases of PICC at the Breast Center of the Fourth Hospital of Hebei Medical University. The success rate, operation time, and procedures of catheterization, as well as the catheterization‐related complications, catheter indwelling‐related complications, and the utilization conditions were compared between these two methods.ResultsOur results showed that the success rate of catheterization was relatively higher in PICC group (99.5%) than the TIVAD group (99.0%)(χ2 = 3.521, P = 0.038), and the operation time and the rate of catheterization‐related complications were lower in PICC (18.65 ± 4.7603 min, 0.91%) compared to TIVAD (29.55 ± 4.0843 min, 1.59%)(t = 38.000, P < 0.01, χ2 = 3.578, P = 0.035). However, the rate of catheter indwelling‐related complications was lower in TIVAD group (2.47%) than the PICC group (3.62%)(χ2 = 5.227, P = 0.016), and the catheter care was also better in TIVAD.ConclusionsBased on these analyses, we recommended TIVAD for the patients who need long‐term and high‐dose chemotherapy and PICC for the patients who need short chemotherapy cycle and live close to the hospital.
The effect of surfactant concentration, salinity, temperature, and pH on surfactant adsorption for chemical enhanced oil recovery: a review
Authors: Belhaj Ahmed Fatih , Elraies Khaled Abdalla , Mahmood Syed Mohammad , Zulkifli Nazliah Nazma , Akbari Saeed , Hussien Osman SalahEldin 
Published: May 2019

AbstractEnhanced oil recovery (EOR) processes have a great potential to maximize oil recovery factor of the existing reservoirs, where a significant volume of the unrecovered oil after conventional methods is targeted. Application of chemical EOR techniques includes the process of injecting different types of chemicals into a reservoir to improve the overall sweep efficiency. Surfactant flooding is one of the chemical EOR used to reduce the oil–water interfacial tension and to mobilize residual oil toward producing wells. Throughout the process of surfactant flooding, selecting a suitable surfactant for the reservoir conditions is quite challenging. Surfactants tend to be the major factor associated with the cost of an EOR process, and losing surfactants leads to substantial economic losses. This process could encounter a significant loss of surfactant due to adsorption into the porous media. Surfactant concentration, salinity, temperature, and pH were found to be as the main factors that influence the surfactant adsorption on reservoir rocks. Most of the research has been conducted in low-temperature and low-salinity conditions. Only limited studies were conducted in high-temperature and high-salinity (HT/HS) conditions due to the challenging for implementation of surfactant flooding in these conditions. This paper, therefore, focuses on the reviews of the studies conducted on surfactant adsorption for different surfactant types on different reservoir rocks under different reservoir conditions, and the influence of surfactant concentration, salinity, temperature, and pH on surfactant adsorption.