bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Literature Review of the Current State of Knowledge Related to Interventions for Bereaved Parents
Authors: Dias Nancy , Hendricks-Ferguson Verna L. , Wei Holly , Boring Elizabeth , Sewell Kerry , Haase Joan E. 
Published: July 2019

Aims: The purpose of this systematic literature review is to describe the interventions for bereaved parents, evaluate intervention effectiveness through study methodology rigor, replicability, and theoretical foundations. Methods: We searched MEDLINE via PubMed (1966-2018), CINAHL (1937-present), PsycINFO (1887-present), and Embase (1947-present) using various search words and MeSH terms related to the study purpose. A blinded screening of title/abstract was performed, with conflicting inclusion decisions resolved through group discussions. Matrices for remaining articles were created and discussed among the team. The levels of evidence of the 9 records were rated from very low to high based on the Grading of Recommendations Assessment, Development, and Evaluation guidelines. Results: Our initial pool included 1025 articles. After the screening of titles/abstracts, 63 articles were retained for full-text reviews. Evaluated based on the inclusion/exclusion criteria, 9 records met the review criteria. Of the 9 records, 1 was graded as very low, 3 low, and 5 low to moderate. The interventions for bereaved parents varied from using single-model interventions such as expressive arts therapy and telephone support to multimodal interventions that combined resources (ie, peer support, resource packets, and health-care support). Only 1 study explicitly illustrated how its bereavement intervention was designed based on the proposed theoretical model. Conclusions: This review highlights the need for individualized, well-tested, and effective bereavement care interventions to support bereaved parents. In summary, the state of the science on interventions for bereaved parents is poor and much work needs to be done to effectively address the needs of bereaved parents, including both their physical and emotional health needs.
The quality of reporting RCT abstracts in four major orthodontics journals for the period 2012–2017
Authors: Alharbi Fahad , Almuzian Mohammed 
Published: July 2019

Introduction: Clear reporting of the abstracts of randomised controlled trials (RCTs) facilitates the assessment and identification of such trials. Aim: To assess whether authors in the orthodontic field of research currently report RCT abstracts adequately, as defined by the Consolidated Standards of Reporting Trials (CONSORT) statement. Design: An observational retrospective study. Methods: Electronic searches with supplementary hand searching were undertaken to identify RCTs published in (1) American Journal of Orthodontics and Dentofacial Orthopedics ( AJO-DO), (2) Angle Orthodontist ( AO), (3) European Journal of Orthodontics ( EJO) and (4) Journal of Orthodontics ( JO) for the period from January 2012 to December 2017. The completeness of the abstract reporting was evaluated using a modified CONSORT for abstract statement checklist. Results: A total of 3678 articles were retrieved, but only 224 RCT abstracts were identified and assessed. A high volume of RCTs were published with either the AO (39%) or AJO-DO (32%); the majority of the RCT abstracts (93.6%) were structured. The mean overall abstract reporting quality score was 69.1% (95% confidence interval = 67.5–70.7). In relation to individual quality items, the majority of the RCT abstracts (range = 96–100%) demonstrated clear reporting of the author/contact details, trial design, participants, interventions, objectives, outcomes, number of participants randomised to each group, recruitment, results and conclusions. However, reporting of the title, trial registration, funding and number of analysed participants were only moderately adequate and reporting of the assessment of blinding and adverse events were the least-reported items in the identified abstracts. Conclusions: As several CONSORT reporting items were poorly reported, it is the responsibility of authors, referees and editors alike to ensure that the CONSORT guidelines are followed.
Assessing financial capability among people with disabilities
Authors: McGarity Stephen V , Okech David O , Risler Edwin , Clees Thomas J 
Published: July 2019

Summary People with disabilities are five times more likely to experience poverty than the general population, yet very little is known about how financial capability can help increase their financial well-being. Using secondary data from the 2015 National Financial Capabilities Study, this study used path analysis to test Sherraden’s theoretical model of building financial capability on a nationally representative sample of people with disabilities. This included assessing how variables of ability (i.e., financial literacy) and variables of opportunity (i.e., financial inclusion) combine to improve one’s financial well-being and stability. Findings Multiple fit indices suggested that the data fit the path model well: χ2 = 37.73 (14), p = .001, RMSEA = 0.04 (90% CI: 0.03–0.05), TLI = 0.97, CFI = 0.99. Findings indicate that financial literacy and financial access both impact the financial well-being in this sample of people with disabilities ( N = 1232). Also, access to financial products moderated financial literacy to increase its impact. This study empirically substantiated the selected financial capability framework. Applications Implications of this study are targeted toward social work researchers and practitioners. There have been very few empirical studies on building financial capability among people with disabilities, so this article serves as a foundation for much needed research in this area while also filling a gap in the extant literature. Additionally, disability case managers will find this research useful, as it provides evidence for practical steps they can take to help their clients work toward achieving financial well-being.
Embodied Social Work Practice Within Risk Society
Authors: Smeeton Joe , O’Connor Patrick 
Published: July 2019

This paper critically discusses the limitations of theorising social work from psychological and sociological perspectives and argues that phenomenology offers more opportunity to understand the embodied experiences of service users and social workers themselves. The paper argues that psychology and sociology have a limited analysis of being-in-the-world, which ought to be social work’s primary consideration. The paper offers an overview of the sociology of risk before embarking on an extensive description and discussion of Heidegger’s and Merleau-Ponty’s phenomenology applied to the lived experience of child protection social workers working within risk society. The argument is put that phenomenology is a useful tool for understanding the lived experience of social work practitioners. Findings: The authors conclude that embodied social work practice containing fear and anxiety can be thought of as akin to taking part in extreme risk sports and that this is an unhealthy experience that is likely to skew decision-making and adversely affect the lives of social workers and service users. Applications: The authors argue that phenomenology can enhance understanding of practice and decision-making and offers insights into the lived experience of social workers. Phenomenology is useful for helping social workers negotiate risk-saturated environments, through a focus on meaning.
Efficacy and safety of Gelsectan for diarrhoea‐predominant irritable bowel syndrome: A randomised, crossover clinical trial
Authors: Trifan Anca , Burta Ovidiu , Tiuca Nicoleta , Petrisor Diana Corina , Lenghel Augustin , Santos Javier 
Published: July 2019

BackgroundIrritable bowel syndrome (IBS) is highly prevalent and presents a clinical challenge. Gelsectan is a medical device containing xyloglucan (XG), pea protein and tannins (PPT) from grape seed extract, and xylo‐oligosaccharides (XOS), which act together to protect and reinforce the intestinal barrier.ObjectiveThe objective of this study is to evaluate the efficacy and safety of XG + PPT + XOS in patients with diarrhoea‐predominant IBS (IBS‐D).MethodsIn this double‐blind study, 60 patients were randomly assigned to receive XG + PPT + XOS or placebo for 28 days, then crossed over to the alternative treatment. Patients were followed for 60 days.ResultsAt Day 28, a significantly higher proportion of patients starting treatment with XG + PPT + XOS than placebo (87 vs 0%; p = 0.0019) presented normal stools (Bristol Stool Form Scale type 3−4). At Day 56, a significantly higher proportion of patients who crossed over to XG + PPT + XOS than placebo (93% vs 23%; p = 0.0001) presented normal stools. In the group allocated to receive XG + PPT + XOS after placebo, benefits of XG + PPT + XOS were maintained during follow‐up. Subjective assessments of abdominal pain, bloating, quality of life and general health indicated significant improvement with XG + PPT + XOS over placebo. There were no related adverse events.ConclusionXG + PPT + XOS effectively controlled diarrhoea and alleviated clinical symptoms in patients with IBS‐D, and was well tolerated.
PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia–initiating cells
Authors: Hu Tianyuan , Morita Kiyomi , Hill Matthew C. , Jiang Yajian , Kitano Ayumi , Saito Yusuke , Wang Feng , Mao Xizeng , Hoegenauer Kevin A. , Morishita Kazuhiro , Martin James F. , Futreal P. Andrew , Takahashi Koichi , Nakada Daisuke 
Published: July 2019

Abstract
Oncogenic mutations confer on cells the ability to propagate indefinitely, but whether oncogenes alter the cell fate of these cells is unknown. Here, we show that the transcriptional regulator PRDM16s causes oncogenic fate conversion by transforming cells fated to form platelets and erythrocytes into myeloid leukemia stem cells (LSCs). Prdm16s expression in megakaryocyte-erythroid progenitors (MEPs), which normally lack the potential to generate granulomonocytic cells, caused AML by converting MEPs into LSCs. Prdm16s blocked megakaryocytic/erythroid potential by interacting with super enhancers and activating myeloid master regulators, including PU.1. A CRISPR dropout screen confirmed that PU.1 is required for Prdm16s-induced leukemia. Ablating PU.1 attenuated leukemogenesis and reinstated the megakaryocytic/erythroid potential of leukemic MEPs in mouse models and human AML with PRDM16 rearrangement. Thus, oncogenic PRDM16s expression gives MEPs an LSC fate by activating myeloid gene regulatory networks.
Epigenome-wide association study of lung function level and its change
Authors: Imboden Medea , Wielscher Matthias , Rezwan Faisal I. , Amaral André F.S. , Schaffner Emmanuel , Jeong Ayoung , Beckmeyer-Borowko Anna , Harris Sarah E. , Starr John M. , Deary Ian J. , Flexeder Claudia , Waldenberger Melanie , Peters Annette , Schulz Holger , Chen Su , Sunny Shadia Khan , Karmaus Wilfried J.J. , Jiang Yu , Erhart Gertraud , Kronenberg Florian , Arathimos Ryan , Sharp Gemma C. , Henderson Alexander John , Fu Yu , Piirilä Päivi , Pietiläinen Kirsi H. , Ollikainen Miina , Johansson Asa , Gyllensten Ulf , de Vries Maaike , van der Plaat Diana A. , de Jong Kim , Boezen H. Marike , Hall Ian P. , Tobin Martin D. , Jarvelin Marjo-Riitta , Holloway John W. , Jarvis Deborah , Probst-Hensch Nicole M. 
Published: July 2019

Previous reports link differential DNA methylation (DNAme) to environmental exposures that are associated with lung function. Direct evidence on lung function DNAme is, however, limited. We undertook an agnostic epigenome-wide association study (EWAS) on pre-bronchodilation lung function and its change in adults.In a discovery–replication EWAS design, DNAme in blood and spirometry were measured twice, 6–15 years apart, in the same participants of three adult population-based discovery cohorts (n=2043). Associated DNAme markers (p<5×10−7) were tested in seven replication cohorts (adult: n=3327; childhood: n=420). Technical bias-adjusted residuals of a regression of the normalised absolute β-values on control probe-derived principle components were regressed on level and change of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and their ratio (FEV1/FVC) in the covariate-adjusted discovery EWAS. Inverse-variance-weighted meta-analyses were performed on results from discovery and replication samples in all participants and never-smokers.EWAS signals were enriched for smoking-related DNAme. We replicated 57 lung function DNAme markers in adult, but not childhood samples, all previously associated with smoking. Markers not previously associated with smoking failed replication. cg05575921 (AHRR(aryl hydrocarbon receptor repressor)) showed the statistically most significant association with cross-sectional lung function (FEV1/FVC: pdiscovery=3.96×10−21and pcombined=7.22×10−50). A score combining 10 DNAme markers previously reported to mediate the effect of smoking on lung function was associated with lung function (FEV1/FVC: p=2.65×10−20).Our results reveal that lung function-associated methylation signals in adults are predominantly smoking related, and possibly of clinical utility in identifying poor lung function and accelerated decline. Larger studies with more repeat time-points are needed to identify lung function DNAme in never-smokers and in children.
The Global Initiative for Asthma (GINA): 25 years later
Authors: Boulet Louis-Philippe , Reddel Helen K. , Bateman Eric , Pedersen Søren , FitzGerald J. Mark , O'Byrne Paul M. 
Published: July 2019

The Global Initiative for Asthma (GINA) was launched in 1993 under the auspices of the National Heart, Lung, and Blood Institute, National Institutes of Health, USA, and the World Health Organization to produce a global strategy on asthma management and prevention. Now constituted as a non-profit entity, it continues to produce, on an annual basis, the most widely cited evidence-based report on the optimal management of asthma in both adults and children intended for global use. Although the GINA Report is often viewed and used as an asthma treatment guideline, it is designed to be a clinically oriented strategy document that supports the development of practice guidelines in different countries and regions.Other GINA products, including the report's pocket guides, teaching slide kits and implementation tools, are also offered free of charge for public use. The GINA Scientific Committee comprises recognised international experts from primary, secondary and tertiary centres of care who are actively involved in both the care of patients and research in asthma. The GINA Assembly is a forum for exchange of scientific information and discussions on initiatives to improve asthma care in various countries, focusing on implementation strategies. GINA plays a role in shaping research on the diagnosis and treatment of asthma and informs the development of point of care practice guides and decision support tools. GINA supports the objectives of raising awareness of asthma and improving access to therapy and quality of care for asthmatic patients, in addition to presenting and promoting continuously updated evidence-based treatment approaches for global use.
Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3 (SCA3-tDCS): rationale and protocol of a randomized, double-blind, sham-controlled study
Authors: Maas Roderick P. P. W. M. , Toni Ivan , Doorduin Jonne , Klockgether Thomas , Schutter Dennis J. L. G. , van de Warrenburg Bart P. C. 
Published: July 2019

Abstract
Background
Spinocerebellar ataxia type 3 (SCA3) is the most common subtype among the autosomal dominant cerebellar ataxias, a group of neurodegenerative disorders for which currently no disease-specific therapy is available. Evidence-based options for symptomatic treatment of ataxia are also limited. Recent investigations in a heterogeneous group of hereditary and acquired ataxias showed promising, prolonged effects of a two-week course with daily sessions of cerebellar anodal transcranial direct current stimulation (tDCS) on ataxia severity, gait speed, and upper limb dexterity. The aim of the SCA3-tDCS study is to further examine whether tDCS improves ataxia severity and various (cerebellar) non-motor symptoms in a homogeneous cohort of SCA3 patients and to explore the time course of these effects.

Methods/design
An investigator-initiated, double-blind, randomized, sham-controlled, single-center trial will be conducted. Twenty mildly to moderately affected SCA3 patients (Scale for the Assessment and Rating of Ataxia score between 3 and 20) will be included and randomly assigned in a 1:1 ratio to either cerebellar anodal tDCS or sham cerebellar tDCS. Patients, investigators, and outcome assessors are unaware of treatment allocation. Cerebellar tDCS (20 min, 2 mA, ramp-up and down periods of 30 s each) will be delivered over ten sessions, distributed in two groups of five consecutive days with a two-day break in between. Outcomes are assessed after a single session of tDCS, after the tenth stimulation (T1), and after three, six, and twelve months. The primary outcome measure is the absolute change of the SARA score between baseline and T1. In addition, effects on a variety of other motor and neuropsychological functions in which the cerebellum is known to be involved will be evaluated using quantitative motor tests, static posturography, neurophysiological measurements, cognitive assessment, and questionnaires.

Discussion
The results of this study will inform us whether repeated sessions of cerebellar anodal tDCS benefit SCA3 patients and whether this form of non-invasive stimulation might be a novel therapeutic approach to consider in a neurorehabilitation setting. Combined with two earlier controlled trials, a positive effect of the SCA3-tDCS study will encourage implementation of this intervention and stimulate further research in other SCAs and heredodegenerative ataxias.

Trial registration
NL7321, registered October 8, 2018.
A trust-aware task allocation method using deep q-learning for uncertain mobile crowdsourcing
Authors: Sun Yong , Tan Wenan 
Published: July 2019

Abstract
Mobile crowdsourcing has emerged as a promising collaboration paradigm in which each spatial task requires a set of mobile workers in near vicinity to the target location. Considering the desired privacy of the participating mobile devices, trust is considered to be an important factor to enable effective collaboration in mobile crowdsourcing. The main impediment to the success of mobile crowdsourcing is the allocation of trustworthy mobile workers to nearby spatial tasks for collaboration. This process becomes substantially more challenging for large-scale online spatial task allocations in uncertain mobile crowdsourcing systems. The uncertainty can mislead the task allocation, resulting in performance degradation. Moreover, the large-scale nature of real-world crowdsourcing poses a considerable challenge to spatial task allocation in uncertain environments. To address the aforementioned challenges, first, an optimization problem of mobile crowdsourcing task allocation is formulated to maximize the trustworthiness of workers and minimize movement distance costs. Second, for the uncertain crowdsourcing scenario, a Markov decision process-based mobile crowdsourcing model (MCMDP) is formulated to illustrate the dynamic trust-aware task allocation problem. Third, to solve large-scale MCMDP problems in a stable manner, this study proposes an improved deep Q-learning-based trust-aware task allocation (ImprovedDQL-TTA) algorithm that combines trust-aware task allocation and deep Q-learning as an improvement over the uncertain mobile crowdsourcing systems. Finally, experimental results illustrate that the ImprovedDQL-TTA algorithm can stably converge in a number of training iterations. Compared with the reference algorithm, our proposed algorithm achieves effective solutions on the experimental data sets.
Ketosis and bipolar disorder: controlled analytic study of online reports
Authors: Campbell Iain H. , Campbell Harry 
Published: July 2019

Background
Members of online bipolar disorder forums often report experiences of mood-stabilisation on the ketogenic diet, which has traditionally been used in the treatment of epilepsy. We examined the nature and extent of such reports.

Aims
To investigate associations between a ketogenic diet and mood stabilisation among individuals with bipolar disorder.

Method
We undertook an observational analytic study of free-text comments in online forums about mood effects of dietary interventions (ketogenic, omega-3 enriched or vegetarian) classified by a priori categories of change in mood stabilisation in 274 people with bipolar disorder.

Results
There were 141 (85.5%) free-text comments on ketogenic diets that reported a positive impact on mood stabilisation. Reports of significant mood stabilisation or remission of symptoms over a period were substantially higher for a ketogenic diet than for other diets (93/165, 56.4%, 95% CI 48.4–64.1) v. 14/94, 14.9%, 95% CI 8.4–23.7), odds ratio 7.4, 95% CI 3.8–14.1, P < 0.0001), many with detailed reports of the improvements experienced and several lasting for extended periods (months to years). Other reported associations included fewer episodes of depression (in 41.2%, 95% CI 30.6–52.4 of individuals); improved clarity of thought and speech (28.2%, 95% CI 19.0–39.0); increased energy (25.9, 95% CI 17.0–36.5); and weight loss (25.9%, 95% CI 17.0–36.5).

Conclusions
Despite the inherent limitations of the observational data based on self-reports posted online, the association strength and reports of sustained benefit support a hypothesis of a ketogenic diet being associated with beneficial effects on mood stabilisation. Caution should be exercised in interpreting this data until a controlled trial can be carried out to examine this hypothesis. These preliminary observations are generally consistent with a mitochondrial dysfunction component to bipolar disorder aetiology with ketones bypassing a block between glycolysis and the tricarboxylic acid cycle.

Declaration of interest
None.
HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond
Authors: Sabharwal Navin , Sharifi Nima 
Published: July 2019

Abstract
Castration-resistant prostate cancer (PCa) almost invariably occurs after androgen deprivation therapy for metastatic disease and is driven in part by androgen synthesis within the tumor. 3β-hydroxysteroid dehydrogenase isoenzyme-1 catalyzes the conversion of adrenal precursor steroids into potent androgens essential for PCa progression. A common 1245 A→C missense-encoding single nucleotide polymorphism in HSD3B1 (rs1047303), the gene that encodes this enzyme, leads to a more stable protein that is resistant to degradation and thus increased production of potent androgens from adrenal precursors, facilitating castration-resistant PCa development. Consistent with this mechanism, this adrenal-permissive HSD3B1(1245C) genotype is associated with inferior outcomes after androgen deprivation therapy for advanced PCa, and increased sensitivity to pharmacologic blockade of adrenal precursors in metastatic disease. Herein, we review current knowledge of the mechanisms conferred by HSD3B1 genotype to alter androgen physiology and accelerate development of castration-resistant disease and its associations with clinical PCa outcomes. In light of its effect on steroid physiology, we also discuss its potential associations with non-PCa phenotypes.