bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphology of the Vieussens valve and its imaging in cardiac multislice computed tomography
Authors: Żabówka Anna , Hołda Jakub , Strona Marcin , Koziej Mateusz , Krawczyk‐Ożóg Agata , Jasińska Katarzyna A. , Kuniewicz Marcin , Lelakowski Jacek , Hołda Mateusz K. 
Published: June 2019

AbstractIntroductionTo deliver accurate morphological descriptions of the Vieussens valve (VV) and to investigate whether this structure could be visualized using standard contrast‐enhanced electrocardiogram‐gated multislice computed tomography (MSCT).MethodsA total of 145 human autopsied hearts and 114 cardiac MSCT scans were examined.ResultsThe VV was observed in both study groups, however, the detection rate was significantly worse in the MSCT examination (18.4% in MSCT vs 62.1% in cadavers, P < .0001). The VV height was larger in MSCT patients (2.8 ± 1.2 vs 5.4 ± 1.7 mm; P < .0001). No significant difference was found in the measured distance between the VV and the coronary sinus ostium between the two separate subgroups (27.3 ± 9.5 vs 24.4 ± 5.8 mm; P = .18). In autopsied material the most frequent valve location was the anterior wall of the coronary sinus (43.3%); the same was observed in MSCT scans (71.4%).ConclusionThe VV is a common heart structure, present in over 60% of humans, located mainly on the anterior and superior circuit of the coronary sinus, with relatively high morphological variability. Large VVs, which pose a significant obstacle in catheterization procedures, may be visualized using standard‐protocol contrast‐enhanced cardiac MSCT.
Studies on Woloszynskioid Dinoflagellates X: Ultrastructure, Phylogeny and Colour Variation in Tovellia rubescens n. sp. (Dinophyceae)
Authors: Pandeirada Mariana S. , Craveiro Sandra C. , Daugbjerg Niels , Moestrup Øjvind , Domingues Pedro , Calado António J. 
Published: June 2019

AbstractThe external morphology and internal cell fine structure of a new species of Tovelliaceae, Tovellia rubescens n. sp., is described. Phylogenetic analyses based on partial LSU rDNA sequences place the new species in a clade containing Tovellia species that accumulate red pigments and identify T. aveirensis as its closest known relative. Cells of T. rubescens n. sp. were mostly round and had the cingulum located near the middle, with its ends displaced about one cingular width. Small numbers of distinctly flat cells appeared in culture batches; their significance could not be determined. Cells of the new species in culture batches progressively changed from a yellowish‐green, mainly due to chloroplast colour, to a reddish‐brown colour that appeared associated with lipid bodies. The switch to a reddish colour happened earlier in batches grown in medium lacking sources of N or P. Pigment analyses by HPLC‐MS/MS revealed the presence of astaxanthin and astaxanthin‐related metabolites in the new species, but also in T. aveirensis, in which a reddish colour was never observed. The chloroplast arrangement of T. rubescens n. sp. resembled that of T. aveirensis, with lobes radiating from a central pyrenoid complex. The flagellar apparatus and pusular system fell within the general features described from other Tovelliaceae. A row of microtubules interpretable as a microtubular strand of the peduncle was present. Spiny resting cysts with red contents and an ITS sequence identical to that of cultured material of the new species were found in the original locality.
Analyzing Hospital Transfers Using INTERACT Acute Care Transfer Tools: Lessons from MOQI
Authors: Popejoy Lori L. , Vogelsmeier Amy A. , Alexander Greg L. , Galambos Colleen M. , Crecelius Charles A. , Ge Bin , Flesner Marcia , Canada Kelli , Rantz Marilyn 
Published: June 2019

OBJECTIVESWe explored the differences in potentially avoidable/unavoidable hospital transfers in a retrospective analysis of Interventions to Reduce Acute Care Transfers (INTERACT) Acute Transfer Tools (ACTs) completed by advanced practice registered nurses (APRNs) working in the Missouri Quality Improvement (QI) Initiative (MOQI).DESIGNCross‐sectional descriptive study of 3996 ACTs for 32.5 calendar months from 2014 to 2016. Univariate analyses examined differences between potentially avoidable vs unavoidable transfers. Multivariate logistic regression analysis of candidate factors identified those contributing to avoidable transfers.SettingSixteen nursing homes (NHs), ranging from 120 to 321 beds, in urban, metro, and rural communities within 80 miles of a large midwestern city.PARTICIPANTSA total of 5168 residents with a median age of 82 years.MEASUREMENTSData from 3946 MOQI‐adapted ACTs.RESULTSA total of 54% of hospital transfers were identified as avoidable. QI opportunities related to avoidable transfers were earlier detection of new signs/symptoms (odds ratio [OR] = 2.35; 95% confidence interval [CI] = 1.61‐3.42; P < .001); discussions of resident/family preference (OR = 2.12; 95% CI = 1.38‐3.25; P < .001); advance directive/hospice care (OR = 2.25; 95% CI = 1.33‐3.82; P = .003); better communication about condition (OR = 4.93; 95% CI = 3.17‐7.68; P < .001); and condition could have been managed in the NH (OR = 16.63; 95% CI = 10.9‐25.37; P < .001). Three factors related to unavoidable transfers were bleeding (OR = .59; 95% CI = .46‐.77; P < .001), nausea/vomiting (OR = .7; 95% CI = .54‐.91; P = .007), and resident/family preference for hospitalization (OR = .79; 95% CI = .68‐.93; P = .003).CONCLUSIONReducing avoidable hospital transfers in NHs requires challenging assumptions about what is avoidable so QI efforts can be directed to improving NH capacity to manage ill residents. The APRNs served as the onsite coaches in the use and adoption of INTERACT. Changes in health policy would provide a revenue stream to support APRN presence in NH, a role that is critical to improving resident outcomes by increasing staff capacity to identify illness and guide system change. J Am Geriatr Soc 67:1953–1959, 2019
Leveraging Home‐Delivered Meal Programs to Address Unmet Needs for At‐Risk Older Adults: Preliminary Data
Authors: Morris Andrea M. , Engelberg Jessa K. , Schmitthenner Brenda , Dosa David , Gadbois Emily , Shield Renee R. , Akobundu Uche , Thomas Kali S. 
Published: June 2019

BACKGROUNDHome‐delivered meal programs serve a predominantly homebound older adult population, characterized by multiple chronic conditions, functional limitations, and a variety of complex care needs, both medical and social.DESIGNA pilot study was designed to test the feasibility of leveraging routine meal‐delivery service in two home‐delivered meal programs to proactively identify changes in older adult meal recipients’ (clients’) health, safety, and well‐being and address unmet needs.INTERVENTIONMeal delivery personnel (drivers) were trained to use a mobile application to submit electronic alerts when they had a concern or observed a change in a client's condition. Alerts were received by care coordinators, who followed up with clients to offer support and help connect them to health and community services.RESULTSOver a 12‐month period, drivers submitted a total of 429 alerts for 189 clients across two pilot sites. The most frequent alerts were submitted for changes in health (56%), followed by self‐care or personal safety (12%) and mobility (11%). On follow‐up, a total of 132 referrals were issued, with most referrals for self‐care (33%), health (17%), and care management services (17%). Focus groups conducted with drivers indicated that most found the mobile application easy to use and valued change of condition monitoring as an important contribution.CONCLUSIONFindings suggest that this is a feasible approach to address unmet needs for vulnerable older adults and may serve as an early‐warning system to prevent further decline and improve quality of life. Efforts are underway to test the protocol across additional home‐delivered meal programs. J Am Geriatr Soc 67:1946–1952, 2019
Prostate Laser Photovaporization in Older People With and Without Bladder Catheter
Authors: Moiroud Martin , Ait Said Khelifa , Vaudreuil Lionel , Alharbi Feras , Leon Gregoire , Tillou Xavier 
Published: June 2019

OBJECTIVESTo compare results of prostate laser photovaporization (PVP) by age groups to evaluate morbidity and functional results. Then, to specifically analyze surgical data for patients with an indwelling bladder catheter.DESIGNMonocentric retrospective study of a prospective maintained database of all laser PVPs performed at our university hospital between December 2012 and June 2017.SETTINGS AND PARTICIPANTSA total of 305 patients (three groups: younger than 70, 70‐80, and older than 80 years) were operated on in our hospital center for the treatment of urinary tract disorders related to benign prostatic hyperplasia.RESULTSA difference was found between the three age groups, with a higher rate of complications for patients older than 80 years (45%) (P = .013). Rate of patients with postoperative bladder catheters at 1 year was higher for patients older than 80 years (15%) (P = .004). Postoperative quality‐of‐life (QoL) score was worse for patients older than 80 years (P = .04).For patients with an indwelling bladder catheter undergoing surgery, morbidity was greater in patients older than 80 years, but the difference was not significant. International Prostate Symptom Score and QoL score were not significantly different between the three groups.Rate of patients with a remaining bladder catheter at 1 year was higher for patients older than 80 years (17.1% vs 7.1% for patients between 70 and 80, and 4.8% for patients under 70.) but with no statistical difference.CONCLUSIONPVP had a greater morbidity in octogenarians compared to younger subjects. Functional results were less satisfactory for patients older than 80 years compared to younger ones. For subjects operated on with an indwelling bladder catheter, no significant difference in outcome and morbidity was found between the three groups. J Am Geriatr Soc 67:1888–1894, 2019
Photodynamic therapy for severe facial acne vulgaris with 5% 5‐aminolevulinic acid vs 10% 5‐aminolevulinic acid: A split‐face randomized controlled study
Authors: Zhang Jing , Zhang Xiaohui , He Ya , Wu Xiaoyan , Huang Jiamin , Huang Huaiqiu , Lu Chun 
Published: June 2019

AbstractBackgroundPhotodynamic therapy (PDT) with 5‐aminolevulinic acid (ALA) has been described as an effective treatment for severe acne. However, very little evidence exists on the optimal concentration of ALA used in PDT for severe acne.ObjectivesTo compare the efficacy and safety of PDT with 5% ALA vs 10% ALA in severe acne.MethodsTwenty‐three patients with severe facial acne were randomly assigned to receive PDT with 5% ALA or 10% ALA on the left or right side of the face. Four PDT sessions were conducted with a light dose of 96 J/cm2. The reduction rates of lesion counts between the two groups were compared at the week‐4 and week‐12 follow‐up visits. Effective rate at the week‐12 visit was the primary clinical outcome. Pain and other side effects were evaluated at each visit.ResultsThe decrease in inflammatory lesions in the 10% ALA group was greater than that in the 5% ALA group at both week‐4 (79.2% vs 62.5%, P = 0.009) and week‐12 follow‐up visits (88.5% vs 78.3%, P = 0.018), while the decrease in noninflammatory lesion counts between the two groups was not statistically significant at each follow‐up visit. The effective rate in the 10% ALA group was significantly higher than that in the 5% ALA group (95.7% vs 69.6%, P = 0.02). No significant difference was observed in pain scores between the two groups except in the first treatment session.ConclusionsPhotodynamic therapy using 10% ALA was more effective for severe acne than PDT using 5% ALA.
Functional and molecular effects of a green tea constituent on oral cancer cells
Authors: Belobrov Simone , Seers Christine , Reynolds Eric , Cirillo Nicola , McCullough Michael 
Published: June 2019

AbstractBackgroundGreen tea is heavily consumed on a global basis for its health benefits. The active ingredient, (‐)‐epigallocatechin gallate (EGCG), is a major polyphenol demonstrated to inhibit the growth of various non‐oral cancer cell lines and interfere with the carcinogenic process, including downregulation of the epidermal growth factor receptor (EGFR). Our aim was to determine the phenotypic changes of oral cancer cells treated with EGCG and concurrently assess the effect on EGFR expression and activation.MethodsOral cancer cells (H400 and H357) were treated with 10 µg/mL and 20 µg/mL of EGCG for up to 72 hours. Phenotypic changes were assessed by performing cell proliferation analysis and cell migration (Transwell) assays. Expression of EGFR and its phosphorylated form (p‐EGFR) was determined by Western blotting.ResultsCell proliferation of both cell lines was significantly reduced at 48hrs when treated with 20 µg/mL EGCG. However, after 72 hours of treatment the effect of EGCG on cell proliferation ceased. Treatment of both cell lines with 10 µg/mL and 20 µg/mL of EGCG resulted in significant reduction in cell migration. Mechanistically, EGFR expression did not change significantly after treatment with EGCG; however, there was a reduction in its phosphorylated form.ConclusionEGCG transiently inhibits both cell proliferation and migration of oral cavity cancer cells. This effect is associated with a decrease in the expression of phosphorylated EGFR. It is possible that more frequent bursts of EGCG could result in a persistent and sustained cancer inhibition, but this requires further research for clarification.
Isolation by resistance analysis reveals major barrier effect imposed by the Tsinling Mountains on the Chinese wood frog
Authors: Atlas J. E. , Fu J. 
Published: June 2019

AbstractAmphibians are excellent model systems for studying how heterogeneous landscapes drive population differentiation. Though mountain ridges have been widely implicated as barriers to amphibian dispersal, a landscape genetic study by Zhan et al. (BMC Genet, 10, 2009, 17) indicated that the Tsinling Mountains of northwestern China did not significantly impede gene flow of the Chinese wood frog (Rana chensinensis). Using their published genetic data, we re‐assessed the impact of elevation, land cover, and roads on the Chinese wood frog using an isolation by resistance (IBR) approach, which allows for the modeling of complex and heterogeneous landscapes unavailable in classical population genetic analysis. We developed a novel method for optimization of IBR analysis using Circuitscape involving initial permutation‐based optimization of the correlation coefficient obtained through partial Mantel tests, followed by subsequent sensitivity analysis to improve upon the model’s biological relevance. Our results indicated that mountain ridges indeed functioned as barriers to dispersal of Chinese wood frogs, and that previous conclusions were based on methodological limitations. Furthermore, a prominent threshold effect at elevations from 1500–2000 m was evident, with elevations below this range minimally impeding gene flow and higher elevations having a significant barrier effect. We suggest that a combination of expert opinion, sensitivity analysis, and permutation‐based optimization procedures in landscape genetic studies will likely generate models that are both highly explanatory and biologically relevant.
Advances in nanotechnology for sustainable aquaculture and fisheries
Authors: Shah Bakht Ramin , Mraz Jan 
Published: June 2019

AbstractIn recent years, aquaculture is considered a fastest‐blooming global food industry, playing a crucial role in fulfilling the increased demand for animal protein requirements. However, disease prevalence, chemical contamination, environmental degradation and ineffective feed utilization are the factors that drastically hinder the outcome of this sector in aiding to achieve global food security. In this regard, new avenues have been paved in science and technology to cope with these challenges in aquaculture. Among these, nanotechnology has emerged a tremendous potential to improve aquaculture with novel nanotools. This review critically analyses the advances in the application of nanoparticles and emulsion‐based systems to fish disease prevention, water purification and delivery of nutrients. On the other hand, as the use of antibiotics and other chemical antimicrobial agents, synthetic compounds as growth enhancers not only leads to aquaculture pollution but also consumer's reluctance. Therefore, the importance of ecofriendly, non‐toxic natural strategies to promote sustainable aquaculture has also been highlighted.
Assessment of the optimal age for a preventive ultrasonographic screening of the uterine health in bitches
Authors: Melandri Monica , Barella Gabriele , Alonge Salvatore 
Published: June 2019

AbstractStudies about prevalence of uterine pathologies in bitches are scarce. Although correlation between age and uterine disorders was documented, the most suitable age for a preventive sonographic screening has not been proposed yet. Present study aimed to estimate the eligible age for an ultrasonographic screening of uterine abnormalities in dogs. Data regarding ultrasound examination and clinical records of non‐pregnant intact females were retrospectively analysed. The age of each bitch was expressed as age ratio (actual/maximum age expected for the respective breed). The cut‐off age ratio was determined by a ROC curve for overall uterine abnormalities. Frequencies of different abnormalities below and over the cut‐off derived from the ROC curve were calculated and statistically analysed by chi‐Square and OR. Prevalence of three categories of ultrasonographic findings was as follows: cystic endometrial hyperplasia (CEH) 18%; uterine collections (UC) 10.5%; masses (M) 1.3%. By the cut‐off age ratio (0.325), derived by ROC curve (AUC = 0.91; SP 84.23%; SE 79.2%; PPV 83.4%; NPV 80%), 228 cases were divided into two subgroups: bitches over (exposed group: n.83) and below cut‐off (control group: n.145). All abnormalities resulted more frequent in exposed group: OR was 24.96 (p < 0.0001: 71.1% over vs. 9% below cut‐off) for overall abnormalities; 13.68 (p < 0.0001: 40.9% vs. 4.8%) for CEH; 6.13 (p < 0.002: 21.7% vs. 4.1%) for UC; 12.65 (p = 0.09: 3.6% vs. 0%) for M. Cystic endometrial hyperplasia represents the most common finding in adult bitches, followed by UC. A preventive sonographic screening for uterine abnormalities should start from 33% of expected longevity to preventively select animals requiring further evaluations.
Clostridium difficile shedding by healthy dogs in Nigeria and Malawi
Authors: Weese J. Scott , Mshelbwala Philip Paul , Lohr Frederic 
Published: June 2019

AbstractThe objectives of this study were to determine the prevalence and characteristics of Clostridium difficile shedding in owned dogs in Nigeria and Malawi. Clostridium difficile was isolated from 31/120 (26%) dogs in Nigeria and 11/92 (12%) dogs in Malawi (p = 0.012). Overall, 22/42 (52%) isolates were toxigenic; 17/31 (55%) from Nigeria and 5/11 (45%) from Malawi. All toxigenic isolates possessing tcdA and tcdB, and only one also possessed cdtA/B. Sixteen different ribotypes were found, ten (63%) of which were non‐toxigenic. Most isolates corresponded to ribotypes that have been previously identified in humans or livestock. The role of dogs in transmission of C. difficile and the clinical implications of C. difficile shedding in dogs remain unclear. These data indicate that dogs could act as a source of C. difficile for exposure of other species, including humans; however, the true risk is unknown. Further study of the ecology of C. difficile and the role of dogs in disease of humans and other domestic animals is indicated.
Reducing the Loss of Velocity and Power in Women Athletes via Rest Redistribution
Authors: Merrigan Justin J. , Tufano James J. , Oliver Jonathan M. , White Jason B. , Fields Jennifer B. , Jones Margaret T. 
Published: June 2019

Purpose: To examine rest redistribution (RR) effects on back squat kinetics and kinematics in resistance-trained women. Methods: Twelve women from strength and college sports (5.0 [2.2] y training history) participated in the randomized crossover design study with 72 hours between sessions (3 total). Participants completed 4 sets of 10 repetitions using traditional sets (120-s interset rest) and RR (30-s intraset rest in the middle of each set; 90-s interset rest) with 70% of their 1-repetition maximum. Kinetics and kinematics were sampled via force plate and 4 linear position transducers. The greatest value of repetitions 1 to 3 (peak repetition) was used to calculate percentage loss, [(repetition 10–peak repetition)/(peak repetition) × 100], and maintenance, {100–[(set mean–peak repetition)/(peak repetition)] × 100}, of velocity and power for each set. Repeated-measures analysis of variance was used for analyses (P < .05). Results: Mean and peak force did not differ between conditions. A condition × repetition interaction existed for peak power (P = .049) but not for peak velocity (P = .110). Peak power was greater in repetitions 7 to 9 (P < .05; d = 1.12–1.27) during RR. The percentage loss of velocity (95% confidence interval, –0.22% to –7.22%; P = .039) and power (95% confidence interval, –1.53% to –7.87%; P = .008) were reduced in RR. Mean velocity maintenance of sets 3 (P = .036; d = 1.90) and 4 (P = .015; d = 2.30) and mean power maintenance of set 4 (P = .006; d = 2.65) were greater in RR. Conclusion: By redistributing a portion of long interset rest into the middle of a set, velocity and power were better maintained. Therefore, redistributing rest may be beneficial for reducing fatigue in resistance-trained women.
Social work education and training in mental health, addictions and suicide: a scoping review protocol
Authors: Kourgiantakis Toula , Sewell Karen , McNeil Sandra , Logan Judith , Lee Eunjung , Adamson Keith , McCormick Megan , Kuehl Dale 
Published: June 2019

IntroductionSocial workers are among the largest group of professionals in the mental health workforce and play a key role in the assessment of mental health, addictions and suicide. Most social workers provide services to individuals with mental health concerns, yet there are gaps in research on social work education and training programmes. The objective of this scoping review is to examine literature on social work education and training in mental health, addictions and suicide.Methods and analysisUsing a scoping review framework developed by Arksey and O’Malley, we will search for literature through seven academic databases: PsycINFO, Sociological Abstracts, CINAHL Plus, Social Sciences Abstracts, Education Source, ERIC and Social Work Abstracts. Two independent reviewers will screen articles utilising a two-stage process. Titles and abstracts will be reviewed in the first stage and full texts will be reviewed in the second stage. Selected articles that meet inclusion criteria will be charted to extract key themes and they will be analysed using a qualitative thematic analysis approach.Ethics and disseminationThis review will fill a knowledge gap in social work education and training in mental health, addictions and suicide. Ethics approval is not required for this scoping review. Through dissemination in publications and relevant conferences, the results may guide future research and education in social work.