bluuebunny/crossref_metadata_2025_split huggingface dataset:
QSAR Analysis of Multimodal Antidepressants Vortioxetine Analogs Using Physicochemical Descriptors and MLR Modeling
Authors: Rajathei David M. , Parthasarathy Subbiah , Selvaraj Samuel 
Published: October 2018

Background:Vortioxetine is a multimodal antidepressant drug with combined effects on SERT as an inhibitor, 5-HT1A as agonist and 5-HT3A as an antagonist. Series of vortioxetine analogs have been reported as multi antidepressant compounds and they block serotonin transport into the neuronal cells, activate the postsynaptic 5-HT1A receptors and eliminate the low activity of 5-HT3A receptors.Objective:To explore the important properties of vortioxetine analogs involved in antidepressant activity by developing 2D QSAR models.Methods:Selections of significant descriptors were performed by Least Absolute Shrinkage and Selection Operator (LASSO) method and, the Multiple Linear Regression (MLR) method and All Subsets and GA algorithm included in QSARINS software were used for generating QSAR models. Further, the virtual screening was performed based on bioactivity and structure similarity using the PubChem database.Results:The four descriptor model of complementary information content (CIC2), solubility (bcutp3), mass (bcutm8) and partial charge in van der Waals surface area (PEOEVSA7) of the molecules is obtained for SERT inhibition with the significant statistics of R2= 0.69, RMSEtr= 0.44, R2 ext= 0.62 and CCCext= 0.78. For 5-HT1A agonist, the two descriptor model of molecular shape (Kappm3) and van der Waals volume of the atoms (bcutv11) with R2= 0.78, RMSEtr= 0.33, R2 ext = 0.83, and CCCext= 0.87 is established. The three descriptor model of information content (IC3), solubility (bcutp9) and electronegativity (GATSe5) of the molecules with R2= 0.61, RMSEtr= 0.34, R2 ext= 0.69 and CCCext= 0.72 is obtained for 5-HT3A antagonist. The antidepressant activities of 16 virtual screened compounds were predicted using the developed models.Conclusion:The developed QSAR models may be useful to predict antidepressant activity for the newly synthesized vortioxetine analogs.
Гипотеза о «заградительном ряде» для дзета-функций моноидов с экспоненциальной последовательностью простых
Authors: Добровольский Н. Н. , Добровольский М. Н. , Добровольский Н. М. , Балаба И. Н. , Реброва И. Ю. 
Published: October 2018

В работе продолжено изучение нового класса рядов Дирихле — дзета-функции мо­ноидов натуральных чисел. Прежде всего детально изучена дзета-функция ????(M(g)|a) геометрической прогресс М(q) с первым членом равным 1 и произвольным натураль­ным знаменателем q > 1, которая является простейшем моноидом натуральных чисел с однозначным разложением на простые элементы моноида. Для мероморфной функции ????(M(g)|a) = qa/qα -1, имеющей множество полюсовS(M(q)) ={2πikl/lnq│k ∈Z}получены представления:ζ(M(q)|α) = ∞ ∏︁ n=1(1 + α2 ln2 q 4π2n2 )︂−1 = 1 2 + 1 αlnq + ∞ ∑︁ n=1 2αlnq α2 ln2 q + 4n2π2 = = q α 2 αlnq 4π2 Γ(︂αilnq 2π )︂Γ(︂−αilnq 2π )︂.Для дзета-функции ζ(M(p~)|α) моноида M(p~) с конечным числом простых чиселp~ = (p1,...,pn) получено разложение в бесконечное произведениеζ(M(p~)|α) =P(p~)α 2 αnQ(p~)n ∏︁ ν=1∞ ∏︁ m=1(︂1 + α2 ln2 pν 4π2m2 )︂−1 ,где P(p~) = p1 ...pn, Q(p~) = lnp1 ...lnpn, и найдено функциональное уравнение ζ(M(p~)|−α) = (−1)n ζ(M(p~)|α) P(p~)α .Для моноида натуральных чисел M*(p~) = N · M−1(p~) с однозначным разложением на простые множители, состоящим из натуральных чисел n взаимно простых с P(p~) = p1 ...pn, и для эйлерово произведение P(M*(p~)|α), состоящего из сомножителей по всем простым числам отличным от p1,...,pn, найдено функциональное уравнение ζ(M*(p~)|α) = M(p~,α)ζ(M*(p~)|1−α), где M(p~,α) = M(α)· M1(p~,α) M1(p~,1−α) , M1(p~,α) = n ∏︁ ν=1(︂1− 1 pα ν)︂.Доказано, что для любого бесконечного множества простых P1 не существует аналитической функции равной lim n→∞ ζ(M(p~n)|α) на всей комплексной плоскости.Сформулирована гипотеза о заградительном ряде для любого экспоненциального множества PE простых чисел.В заключении рассмотрены актуальные задачи с дзета-функциями моноидов натуральных чисел, требующие дальнейшего исследования.
Дифракция плоской звуковой волны на двух упругих цилиндрах с неоднородными покрытиями
Authors: Толоконников Л. А. 
Published: October 2018

В статье получено аналитическое решение задачи дифракции плоской звуковой волны на двух однородных упругих цилиндрах с радиально-неоднородными покрытиями, находящимися в идеальной жидкости. Волновые поля в содержащей среде и однородных упругих телах находятся аналитически, а для нахождения полей смещений в неоднородных покрытиях построена краевая задача для системы обыкновенных дифференциальных уравнений второго порядка.С помощью непрерывно-неоднородных упругих покрытий можно эффективно изменять характеристики рассеяния тел в определенных направлениях, если подобрать соответствующие законы неоднородности для механических параметров покрытия. Задача представляет интерес для изучения дифракции звука на решетке цилиндрических тел, а также служит необходимым элементом решения методом мнимых источников задачи о дифракции звука на одиночном однородном упругом цилиндре с неоднородным покрытием, находящемся вблизи акустически мягкой или абсолютно жесткой плоской поверхности.
ANALISIS KARYA SISWA DALAM MENGGAMBAR MANUSIA DITINJAU DARI ASPEK ANATOMI DAN PROPORSI PADA KELAS VIII SMP NEGERI 1 TANJUNG BALAI TAHUN AJARAN 2016/2017
Authors: Aulia Aulia , Sihite Onggal 
Published: October 2018

ABSTRAK Penelitian ini bertujuan untuk mendeskripsikan hasil karya siswa dalam menggambar manusia, pada mata pelajaran seni budaya di SMP Negeri 1 Tanjung Balai. Populasi penelitian ini adalah keseluruhan karya siswa kelas VIII SMP Negeri 1 Tanjung Balai yang berasal dari 10 kelas berjumlah 339 karya, sedangkan sampel penelitian diambil dengan teknik Random Sampling, yaitu dengan mengacak kelas sehingga terpilih kelas VIII2 yang berjumlah 26 karya. Pada penelitian menunjukkan: 17 (65,38%) karya dapat menampilkan anatomi manusia cukup tepat, 9 (34,61%) karya dapat menampilkan anatomi manusia tidak tepat, 16 (61,53%) karya dapat menampilkan proporsi manusia cukup tepat dan 10 (4,34%) karya menampilkan proporsi manusia tidak tepat dari 26 siswa. Kesimpulan dari hasil karya siswa sudah menampilkan hasil yang cukup tepat terlihat dari bentuk anatomi dan proporsi walaupun tidak semua mampu memenuhi kriteria gambar yang diinginkan. Saran bagi pendidik untuk lebih banyak menambah pembelajaran dan pengadaan referensi tentang anatomi dan proporsi. Kata Kunci: menggambar manusia, anatomi, proporsi
IDENTIFIKASI KRIPTOSPORIDIOSIS DI PASIEN ANAK HIV DENGAN DIARE KRONIS DI RUANG GASTRO ANAK
Authors: Nugraha Jusak , Rahmawati Febtarini , Husada Dominicus 
Published: October 2018

Based on the results of overseas researchers, Cryptosporidiosis occurs in immunosuppressive cases with chronic diarrhoea. In this study the researchers would like to know exactly whether that Cryptosporidiosis occurs also in paediatric HIV patients. The latest data show that the incidence of opportunistic infection is characterized by persistent diarrhoea and severe malnutrition as a complication of the paediatric HIV-infected patients is increasing. The objects of the research were fifteen paediatric HIV-infected patients which treated at the Paediatric Gastro Ward of Dr. Soetomo Hospital Surabaya due to persistent diarrhoea. Paediatric patients were less than five years old, suffered persistent diarrhoea more than two weeks with severe malnutrition. Stool specimens were transported using 10% formalin. The stool suspension was filtered, and distilled water was added followed by centrifugation (sedimentation method). The precipitate material was placed on a glass object and dried, and then fixed by methanol and stained with Acid Fast Staining and trichrome staining. The protozoa Cryptosporidium spp. was observed under a binocular microscope with 100í— magnification (immersion oil) objective. The result was confirmed as positive if a red spherical or oval formation of oocyste of 4–6 micron appeared. Sixty percent of the 15 paediatric HIV-infected patients with chronic diarrhoea showed positive cryptosporidiosis. Cryptosporidiosis is one of the opportunistic infections resulting in chronic diarrhoea in paediatric HIV-infected patients. The results of the present research indicate that the enteric parasite Cryptosporidium spp. was the main cause of persistent diarrhoea in paediatric HIV-infected patients
POLA KUMAN AEROB DAN KEPEKAAN ANTIMIKROBA PADA ULKUS KAKI DIABETIK
Authors: Kurniawan Liong Boy , Esa Tenri , Sennang Nurhayana 
Published: October 2018

Diabetic foot ulcer is a common complication of diabetic disease which causes morbidity and foot amputation. One major pathogenesis is infection. Microbes which infect are varied. The use of inappropriate antimicrobials can or may cause drugs resistance. Data of microbes pattern and sensitivity test is important and may guide the clinician in giving the initial therapy. The aim of this retrospective study was to know the characteristics, microbial pattern, and the sensitivity to antimicrobial drugs of 31 diabetic foot ulcer patients who were hospitalized at Wahidin Sudirohusodo Hospital, Makassar in the period of January 2009 until June 2010. The study results showed the age mean was 54.06±12.4 years old, and the onset of diabetes mellitus was 7.62±5.77 years. The common microbes were gram negative bacteria (73.52%) including Enterobacter agglomerans, Proteus mirabilis and Klebsiella pneumonia, while the most common gram positive microbe was Streptococcus sp. Gram positive microbes were sensitive to meropenem, ceforoxim and amoxilin, while Gram negative microbes were sensitive to meropenem. Based on this study, the researchers concluded that the most common microbes which infect the feet were gram negative microbes. Gram positive microbes were still sensitive to meropenem, ceforoxim and amoxilin. Gram negative microbes were sensitive to meropenem.
MYCOBACTERIUM TUBERCULOSIS DAN PCR
Authors: Widaningsih Yuyun , Amin Ismawati , Sennang Nurhayana , Bahrun Uleng , Arif Mansyur 
Published: October 2018

TB's coinfection in HIV and AIDS is on the increase together with the high mortality rate. The disseminated TB infection (in blood) of HIV and AIDS patients in Africa (2005) is about 10âˆ’25%. The aim of this study was to identify M.tb disseminated infection in HIV and AIDS patients. In this study was done in six HIV and AIDS patients suffering from suspected TB co infection. The sputum was tested using Fast Acid Bacilli and culture (using LJ and MGIT media) and DST. The identification of M.tb in blood used PCR with IS6110 primer (123 bp). The study was done at Dr. Wahidin Sudirohusodo Hospital, Labuang Baji Hospital, NEHCRI and at the Biomolecular Laboratory of the Medical Faculty, Hasanuddin University. From the six patients, four of them had CD4<50 sel/Î¼L, two patients had FAB positive, three patients had positive LJ culture on day 41–47, three patients had positive MGIT culture on day 9–47 and four patients had positive PCR. In this study there was one case of negative FAB but LJ, MGIT and PCR were positive. There were two cases with positive FAB, culture and PCR, one case with negative FAB and culture but positive PCR. The M.tb disseminated infection was 66.7% in six HIV and AIDS patients.
WAKTU PENYIMPANAN TROMBOSIT TERKAIT JUMLAH DI KONSENTRAT TROMBOSIT
Authors: Samad Raehana , Abdullah Agus Alim , A.P. Kusriny , Arif Mansyur 
Published: October 2018

The transfusion of thrombocyte concentrate is one of the important medical approaches to make the platelet count raised in patients with thrombocytopenia. The TC could change during the storage process, so the in vitro storaging should be considered to minimalize the alterations on the platelet count. The study was aimed to know the impact of storage time to maintain the platelet count stability in TC of transfusion blood by evaluating it. A study with Time Series design was performed in 30 samples of TC of transfusion blood collected from 30 blood donors. The samples was collected from the bag tube of TC and the test is performed as soon as possible by using haematological analyzer (Sysmex KX-21) with an impedance method, the rest of the samples was stored in an agitator on 22±2°C to perform a repeated count on day 5th and 7th. The collected data was analyzed with "Paired T Test”. The results of this study showed that the platelet count in TC of transfusion blood was decreased in the fifth day compared to the first day, but the decreased matter is insignificant, statistically (p=0.13). While after seventh (7) day, the platelet count is decreased significantly (p=0.00). The researchers concluded that the storage of TC for seven (7) days could not maintain the stability of the platelet count of the transfusion blood. There fore is suggested, a further study to evaluate the impact of storage time on platelets viability. So the quality of platelets in TC of transfusion blood can be evaluated.
Membandingkan Partikel Fatis deh dan dong dalam Bahasa Indonesia
Authors: Kulsum Umi 
Published: October 2018

Pengamatan terhadap bahasa Indonesia ragam lisan belum sebanyak pengamatan terhadap ragam tulis. Partikel deh dan dong banyak digunakan dalam ragam lisan dan belum ada yang mengungkap secara detail kedua partikel ini dan/atau membandingkan penggunaan keduanya. Pengamatan mengenai deh dan dong ini meliputi (1) jenis kalimat, (2) posisi, (3) pola, (4) fungsi, dan (5) kesinoniman keduanya. Pengamatan mengenai keduanya menggunakan metode deskriptif dengan teknik penyulihan dan permutasian. Kedua partikel yang diamati mempunyai persamaan dan perbedaan. Kedua partikel ini terdapat pada kalimat deklaratif dan imperatif dengan posisi final atau medial. Selain itu, partikel dong terdapat juga pada kalimat interogatif. Kedua partikel ini tidak ditemukan pada posisi inisial. Posisi final merupakan posisi dominan bagi keduanya. Kedua partikel hampir mempunyai fungsi yang sama, terutama fungsi yang dipunyai keduanya pada kalimat imperatif, yaitu menghaluskan perintah. Akan tetapi, fungsi deh pada kalimat deklaratif lebih bervariasi jika dibandingkan dengan fungsi dong. Namun, dong mempunyai fungsi sebagai penegas pertanyaan dan fungsi ini tidak dipunyai deh. Partikel deh bersinonim dengan dong hanya pada kalimat imperatif, sedangkan pada kalimat interogatif dong tidak bersinonim dengan deh. Partikel deh pada kalimat deklaratif sebagian besar bersinonim dengan dong.
PEMODELAN SEMIPARAMETRIK STATISTICAL DOWNSCALING UNTUK MENDUGA CURAH HUJAN BULANAN DI INDRAMAYU
Authors: Rizki Akbar , Nurussadad Abdul Aziz 
Published: October 2018

Semiparametric statistical downscaling (SD) model is a statistical model which consists of parametric and non-parametric functional relationship between local scale and global scale variable. This study used rainfall intensity in Indramayu as local scale variable and Global Precipitation Climatology Project (GPCP) precipitation as global scale variable. GPCP precipitation data have multicollinearity, therefore they were reduced by principal component analysis. Eight principal components which have been selected then used as the prediktors and rainfall intensity in Indramayu as the response. Semiparametric SD model was used to predict the rainfall intensity in the district of Indramayu. The semiparametric model developed by mixed model approach where the nonparametric relationship is represented using spline with truncated power basis. Linier semiparametric model is the best model to estimate monthly rainfall in indramayu district. The model performance evaluated by RMSEP (root mean square error prediction) and (coefficient of determination). The result shows that the best model have values of RMSEP and are 61.64 and 71%.
APRISIONAMENTO PSÍQUICO NAS ORGANIZAÇÕES: DO MITO À REALIDADE
Authors: Silva Maria Claudete , Lessa Laura Silva Campos 
Published: October 2018

Esse artigo busca explicitar um modelo de defesa que trabalhadores utilizam para permanecerem por muitos anos em uma organização partindo da categoria do mito Golem Laborio, proposto por Thiry-Cherques (2004). Esse modelo representa uma forma de adesão total dos trabalhadores ao sistema, onde vida e sistema se confundem. Buscou-se uma abordagem qualitativa, a partir de estudo de casos múltiplos com oito profissionais em cargo de gestão que trabalham no contexto pesquisado há mais de 15 anos. Os dados foram coletados com entrevistas semiestruturadas, técnicas projetivas e observação direta, o que tornou possível a identificação e classificação dos casos estudados de acordo com o modelo proposto. Os resultados evidenciaram que o trabalho tem uma importância vital na vida das pessoas, que elas não são livres e ficam aprisionadas psiquicamente dentro das próprias armadilhas que criam para se manterem nas suas atividades laborais, pois ficar sem emprego é perder o sentido da vida. Como forma de garantir a subsistência material e sobreviver às pressões impostas no dia a dia, as pessoas acabam desenvolvendo, de forma inconsciente, modelos de defesa.
The Harmonization of Naqlī And ‘Aqlī Approaches In Affirming The Islamic Creed In Dāwūd Al-Faṭānī’s Ward Al-Zawāhir
Authors: Mohamad Hasbullah bin 
Published: October 2018

This paper offers an examination of the scholarship of Dāwūd al-Faṭānī in dealing with the revealed sources (naqlī) and qualified scholarship in the exercise of the intellect (‘aqlī) in affirming the Islamic creed. The author emphasizes the determination of Dāwūd al-Faṭānī on the need to refer to the authority of naqlī and ‘aqlī so as to guard against deviation and exceeding the proper limits of methodological practices towards theological goal of knowing God (ma‘rifat Allāh). A qualitative methodology in which the textual analysis and comparative study was employed to analyse textual materials related to Dāwūd al-Faṭānī especially his writing, the Ward al-Zawāhir. Findings indicate that Dāwūd al-Faṭānī attempted to integrate the naqlī and ‘aqlī approaches, and harmonize such distinctions in dealing with theological approaches especially that of Salaf and Khalaf’s.
Cash Waqf in Sustaining Of Indonesian Society “In Legal & Economic Perspective”
Authors: Sukarmi Sukarmi , Victoria Argo 
Published: October 2018

Abstract
This article aims to make an overview on the rule and significance of cash waqf (waqf al-nuqūd) in Indonesia as a new social tool to alleviate poverty. The author highlights that Cash waqf is introduced as a new concept of waqf to solve many social problems in Muslim society of Indonesia. The qualitative methodology is employed to analyze the issues and development of cash waqf in Indonesia. Findings indicate that the cash waqf has been legalized by both Islamic scholar and national law of Indonesia so that Muslims have a chance to maximize the utilization of their waqf through a well-organized endowment and waqf organization.
Keywords: Waqf, Endowment, Law, Economic, Indonesia
Ahmad Ibrahim Memorial Lecture; Humanitarian Conflicts and Crises: where can ADR play any role?
Authors: Idid Syed Ahmad 
Published: October 2018

I am particularly delighted to be here this afternoon despite the fact that this is the snoozing period. looking at how well prepared you are, and everyone has a smile, I know you are here to share your concerns with what occurs in several parts of the world ...for some time now and continuing today. As I speak here, I received several alerts that there are troubles in Gaza, in Dafur, in Honduras and Urumqi just a few moments ago.
The Attorney General as Public Prosecutor in Malaysia: from Quasi-Judicial to ‘Executive’
Authors: Abu Bakar Baharuddeen 
Published: October 2018

The Public Prosecutor (PP), as the chief criminal law enforcement officer, impacts directly on the public; hence the greater concern for his independence and integrity as exemplified by the security of tenure provision in the 1957 Federal Constitution. This article uncompromisingly holds that the Attorney General (AG) being ‘political’, as he is selected by, negotiates his contract with and may be dismissed by the Prime Minister, should be separated from the position of PP and protected from political interference. This article traces the history of the emasculation of the PP from Independence to the present. It looks at the travails of the AG/PP during the Mahathir years. One is bound to ask: how is the PP, who may be expected to enforce the criminal law against ordinary citizens, to do so against the head of government? It is based on statutory provisions and reported cases which involved the independence, powers and duties and security of tenure provisions and parliamentary debates (Hansard).
The Damning Effect of Terrorism on the Environment: Towards A Sustainable International Legal Framework
Authors: Al-Anezy Eisa 
Published: October 2018

The increasing spate of terrorist activities and its damning effect on the environment through the use of harmful explosive devices calls for a comprehensive study to examine the need for an international legal framework for environmental protection. This paper examines terrorist activities and counter-terror measures and the transboundary pollution effect of such measures in an increasingly populated planet. While adopting an analytical legal research method, this study analyses the environmental effect of terrorism and counter-terror measures using notable terrorist activities such as the 9/11 attack on the United States and relevant international legal instruments promulgated to combat terrorism and its harmful environmental effects. The article concludes that while the act of terrorism should be condemned by all as it is harmful to the environment, counter-terror measures should be well managed to avoid environmental degradation and human collateral damage. An international legal framework will be required to drastically reduce the environmental effect of counter-terror measures.
PENERAPAN PRINSIP-PRINSIP GOOD GOVERNANCE DALAM PELAYANAN PUBLIK DI KANTOR CAMAT SAIL KOTA PEKANBARU
Authors: Nasution Sri Roserdevi 
Published: October 2018

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