bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative exploration of race‐based differences in social support needs of diverse women with breast cancer on adjuvant therapy
Authors: Paladino Andrew J. , Anderson Janeane N. , Graff J. Carolyn , Krukowski Rebecca A. , Blue Ryan , Jones Tameka N. , Buzaglo Joanne , Kocak Mehmet , Vidal Gregory A. , Graetz Ilana 
Published: January 2019

AbstractObjectiveSocial support is a critical component of breast cancer care and is associated with clinical and quality of life outcomes. Significant health disparities exist between Black and White women with breast cancer. Our study used qualitative methods to explore the social support needs of Black and White women with hormone receptor‐positive breast cancer on adjuvant endocrine therapy (AET).MethodsWe conducted four focus group (FG) interviews (N = 28), stratified by race (ie, Black and White) and time on AET. FGs were audiotaped, transcribed, and analyzed according to conventions of thematic analysis.ResultsParticipants noted the importance of having their informational and emotional social support needs met by friends and family members. White participants reported support provided by others with breast cancer was crucial; Black women did not discuss other survivors as part of their networks. Notably, both White and Black participants used the FG environment to provide experiential social support to each other.ConclusionsWhite participants noted that having other breast cancer survivors in their support network was essential for meeting their social support needs. However, Black participants did not reference other breast cancer survivors as part of their networks. Cancer centers should consider reviewing patients' access to experiential support and facilitate opportunities to connect women in the adjuvant phase.
The long‐term impact of cancer: Evaluating psychological distress in adolescent and young adult cancer survivors in Switzerland
Authors: Michel Gisela , François Constanza , Harju Erika , Dehler Silvia , Roser Katharina 
Published: January 2019

AbstractObjectivesAdolescents and young adults (AYAs) are diagnosed with cancer during a critical life period full of psychosocial challenges. They may experience a significant impact of the cancer diagnosis on their psychological health, also in the long term. We aimed to (a) evaluate psychological distress in AYA cancer survivors and compare levels of distress with controls and (b) describe socio‐demographic and cancer‐related characteristics associated with psychological distress.MethodsWe sent a questionnaire to AYA cancer survivors (aged 16‐25 y at diagnosis, survived ≥5 y) registered in the Cancer Registry Zurich and Zug, Switzerland. Psychological distress was measured using the Brief Symptom Inventory‐18 (BSI‐18) assessing anxiety, depression, and somatization and a global severity index (GSI) (cutoff score indicating psychological distress: T ≥ 57). Distress levels were compared between survivors and controls. We used logistic regression to determine associations of socio‐demographic and cancer‐related characteristics with distress.ResultsOf 160 AYA cancer survivors, 34 (21%) reported being distressed (27% in women, 17% in men; P = 0.129). Compared with controls, survivors did not report higher levels of distress (all P values > 0.05). Survivors with migration background and survivors with late effects reported higher levels on GSI, somatization, and anxiety. Higher levels of depression were associated with being female, not being in a partnership, and having late effects.ConclusionsA substantial subgroup of AYA cancer survivors reported psychological distress. Systematically screening for distress and providing psychological follow‐up for survivors at risk may help to provide adequate psychological support.
The performance of explicitly correlated methods for the computation of anharmonic vibrational frequencies
Authors: Agbaglo Donatus , Fortenberry Ryan C. 
Published: January 2019

AbstractAnharmonic vibrational frequencies for closed‐shell molecules computed with CCSD(T)‐F12b/aug‐cc‐pVTZ differ from significantly more costly composite energy methods by a mean absolute error (MAE) of 7.5 cm−1 per fundamental frequency. Comparison to a few available gas phase experimental modes, however, actually lowers the MAE to 6.0 cm−1. Open‐shell molecules have an MAE of nearly a factor of six greater. Hence, open‐shell molecular anharmonic frequencies cannot be as well‐described with only explicitly correlated coupled cluster theory as their closed‐shell brethren. As a result, the use of quartic force fields and vibrational perturbation theory can be opened to molecules with six or more atoms, whereas previously such computations were limited to molecules of five or fewer atoms. This will certainly assist in studies of more chemically interesting species, especially for atmospheric and interstellar infrared spectroscopic characterization.
The feasibility of robotic left‐side hepatectomy with comparison of laparoscopic and open approach: Consecutive series of single surgeon
Authors: Lee Seung Jae , Lee Jae Hoon , Lee Young‐Joo , Kim Song Cheol , Hwang Dae Wook , Song Ki Byung , Shin Sang Hyun , Kwon Jae Woo , Park Gui Suk , Park Ye Jong , Park Kwang‐Min 
Published: January 2019

AbstractBackgroundRecent studies report safety and effectiveness of robotic hepatectomy. In present study, we describe our initial experiences with robotic hepatectomy, focusing on left‐side procedures.MethodsA retrospective review was conducted of 13, 10, and 11 consecutive patients who underwent robotic, laparoscopic, and open left‐side hepatectomy by the single surgeon.ResultsThere were no significant differences in the estimated blood loss, application of Pringle maneuver, postoperative hospital stays, number of IV analgesic injections, or postoperative complications between the robotic and laparoscopic groups. The robotic group had a smaller number of patients applied a Pringle maneuver (8.3 vs 90.9%, P < 0.001), a shorter postoperative hospital stays (7.0 vs 9.0 days, P = 0.044), and a less use of IV analgesics (2.8 vs 8.2, P = 0.005) than the open group.ConclusionsFrom our initial experiences, a robotic left‐side hepatectomy seems to be a feasible and safe procedure when compared with the laparoscopic and open left‐side hepatectomies.
Family firms and the stock market performance of acquisitions and divestitures
Authors: Feldman Emilie R. , Amit Raphael , Villalonga Belén 
Published: January 2019

Research SummaryThis paper explores the stock market performance of acquisitions and divestitures where both, one, or neither of the companies in the transaction are family firms. We find that acquirer shareholder returns are highest when family firms buy businesses from non‐family firm divesters, especially when family chief executive officer (CEO) acquirers buy businesses from non‐family CEO divesters. Additionally, divester shareholder returns are highest when family firms sell businesses to non‐family firm acquirers, especially when family CEO divesters sell businesses to non‐family CEO acquirers. These findings reveal that it is important to consider the characteristics of both the acquiring and divesting firms when analyzing acquisition and divestiture performance, and that the expected gains to family firm acquisitions and divestitures are driven by transactions in which the counterparties are non‐family firms.Managerial SummaryThis paper explores how investors react to acquisitions and divestitures where both, one, or neither of the companies in the deal are family firms. The stock market performance of acquiring firms is highest when family firms buy businesses from non‐family firms, relative to the other three possible combinations of family and non‐family firm acquirers and divesters. Likewise, the stock market performance of divesting firms is highest when family firms sell businesses to non‐family firms, again relative to the other three possible combinations of family and non‐family acquirers and divesters. These findings suggest that investors take into consideration the identities of both the acquiring and divesting firms when evaluating acquisitions and divestitures, and that this has significant implications for the expected performance gains of these transactions.
Contextualizing pubertal development: The combination of sexual partners' age and girls' pubertal development confers risk for externalizing but not internalizing symptoms among girls in therapeutic day schools
Authors: Javdani Shabnam , Sadeh Naomi , White Hope I. , Emerson Erin , Houck Christopher , Brown Larry K. , Donenberg Geri R. 
Published: January 2019

ABSTRACTObjectiveEarly pubertal development is associated with negative health and mental health outcomes. Research on the influence of puberty on mental health underscores a need to examine the interplay between puberty and exposure to environmental risk. This study investigates a more rarely studied aspect of girls' environments – romantic relationships with boyfriends. Specifically, this study examined sexual partner age and the timing of girls' pubertal development in relation to externalizing and internalizing symptoms among female students attending therapeutic day schools in the United States, a population at elevated risk for negative mental health outcomes.MethodsA total of 121 13 to 19‐year‐old adolescent girls (Mean age = 15.4; SD = 1.5) reported on the relative age of their past 3 sexual partners, their age of pubertal onset, and mental health challenges via clinical assessments of externalizing and internalizing symptoms.ResultsForty‐three percent of participants qualified for at least one mental health diagnosis. Earlier pubertal onset predicted greater internalizing symptoms, and this effect did not depend on the age of girls' sexual partners. However, early‐developing girls who also reported having a sexual partner more than 2 years older than them were at increased risk for externalizing symptoms.ConclusionsFindings underscore that sexual relationships are an important risk factor for early‐developing girls already at risk for mental health problems. Early developing girls with older partners may experience stronger social pressure to stay in relationships that expose them to partner violence and delinquency‐related pressure, which combine with interpersonal stress to predict externalizing symptoms.
Serum levels of proteins involved in amyloid‐β clearance are related to cognitive decline and neuroimaging changes in mild cognitive impairment
Authors: Liu Shan , Suzuki Hideaki , Ito Hitomi , Korenaga Tatsumi , Akatsu Hiroyasu , Meno Kohji , Uchida Kazuhiko 
Published: January 2019

AbstractIntroductionAmyloid‐β (Aβ) clearance is important for damage prevention in Alzheimer's disease. We investigated the utility of Aβ clearance proteins as biomarkers for mild cognitive impairment (MCI).MethodsSerum apolipoprotein (apo) A‐I, compliment protein C3 (C3), transthyretin, and cholesterol levels were measured in 273 subjects, and we analyzed the relationship between these levels and brain atrophy and cerebral blood flow in 63 clinically diagnosed mild cognitive impairment, Alzheimer's disease, and nondemented disease control subjects.ResultsApoA‐I and transthyretin levels and the active form of C3:native form of C3 ratio achieved an area under the curve of 0.89 (sensitivity: 83%, specificity: 90%) for detecting late mild cognitive impairment. Atrophy was associated with decreased apoA‐I and high‐density lipoprotein levels. Subjects with reduced cerebral blood flow had lower levels of native form of C3, apoA‐I, high‐density lipoprotein, and total cholesterol. Low native form of C3 and high active form of C3 levels were found in the hippocampi of patients with Alzheimer's disease.DiscussionAβ clearance proteins in the serum are potential biomarkers for mild cognitive impairment evaluation.
Fake News, Real Problems for Brands: The Impact of Content Truthfulness and Source Credibility on consumers’ Behavioral Intentions toward the Advertised Brands
Authors: Visentin Marco , Pizzi Gabriele , Pichierri Marco 
Published: January 2019

The presence of fake news via Internet media compels researchers and practitioners to understand the consequences of this phenomenon on marketing activities. Surprisingly, no marketing study to date has analyzed the effect of fake news on consumers’ evaluations of a brand advertised on the same webpage. To fill this gap, this study empirically investigated whether individuals’ perceptions of fake news transfer to an adjacent brand advertisement. Specifically, we manipulated news truthfulness and source credibility, observing the change in individuals’ responses while distinguishing between objective truthfulness and the perceived credibility of the news. The results confirmed that the news’ objective truthfulness exerts no direct effect on behavioral intentions toward the brand (i.e., intention to purchase, spread word-of-mouth, or visit the brand's store). However, we did uncover a chain of effects whereby the impact of fake news on behavioral intentions was fully mediated by people's perceptions of the news’ credibility, which affected the perceived credibility of the sources, which then influenced brand trust, which finally translated into brand attitudes. From a managerial perspective, this study's results can partially reassure brand managers that their brand advertisements will not suffer from appearing next to fake news when the source itself is credible.
Slow‐Slip Recurrent Pattern Changes: Perturbation Responding and Possible Scenarios of Precursor toward a Megathrust Earthquake
Authors: Luo Yingdi , Liu Zhen 
Published: January 2019

AbstractAdvances in geodetic techniques enable us to detect “slow‐earthquake” transients (e.g., slow‐slip events, SSEs) with improving accuracy and coverage. Recent observations reveal intriguing changes of SSE behavior before and/or after earthquakes. However, the physics behind these observations remain largely unknown. How does SSE pattern change during megathrust earthquake super‐cycle? How do SSEs respond to “external” tectonic perturbations such as stress perturbation from earthquakes, or nontectonic forces such as tidal modulation and seasonal loading? Can SSE pattern changes shed light on the onset of a large earthquake? To address these questions, we employ laboratory‐based rate‐and‐state frictional law on subduction zone faults with realistic frictional properties incorporating megathrust earthquake and SSE regions. We conduct 2‐D/3‐D quasi‐dynamic earthquake cycle simulations to study the “intrinsic” SSE pattern changes as how it evolves at different stages of the earthquake cycle, versus the changes in SSE pattern responding to external stress perturbations. Our results suggest that, despite both intrinsic and perturbation models are capable to introduce large variability in SSE pattern, there are considerable observable characteristics that can be used to differentiate these two models. Without external perturbation the SSE patterns change intrinsically during the super‐cycle. The recurrence interval and peak slip rate of SSEs decrease significantly right before megathrust earthquake and could be used as a potential warning sign. Whereas SSE patterns can vary significantly when perturbed by an earthquake or other tectonic/nontectonic sources. Recurring SSEs can be advanced or delayed by external perturbations, and multiple SSEs can be affected if perturbation is long‐lasting.
Dynamic Plasma Interaction at Io: Multispecies Hybrid Simulations
Authors: Šebek Ondřej , Trávníček Pavel M. , Walker Raymond J. , Hellinger Petr 
Published: January 2019

AbstractThe interaction between the Io plasma torus and Io exhibits significant dynamics resulting from temporal variations of both external conditions in the plasma torus and local conditions in Io's environment. We present analysis of an extensive simulation campaign of the Io plasma interaction under varying interaction conditions performed by using a hybrid multispecies simulation model. We test two models of electron impact ionization, one resulting in plasma production constrained to the upstream hemisphere of Io and the other producing a more symmetric distribution of the plasma with nonnegligible plasma production on the downstream side of Io. In the latter case, the simulation model provides high level of agreement with Galileo measurements of magnetic field obtained during the I0 flyby, where the model captures even smaller‐scale features of the magnetic field profile. Our simulated results provide strong support for the existence of Io's induced dipole field. In this model we assume that induced dipole field moment is antiparallel to the direction of the inducing magnetic field, equivalent to induction in a highly conductive Io. Our results further support the idea that Io's atmosphere collapsed during the Galileo I27 flyby, which manifests itself in the lack of ion heating due to pickup processes in the extended atmosphere. Our results show that the dominant torus species, O+ and S++, are depleted around Io and may exhibit temperature anisotropy, T⊥/T‖ < 1, resulting from merging of ion populations coming from opposite sides of Io along the magnetic field.
Tectonic Controls on Gas Hydrate Distribution Off SW Taiwan
Authors: Berndt C. , Chi W.‐C. , Jegen M. , Lebas E. , Crutchley G. , Muff S. , Hölz S. , Sommer M. , Lin S. , Liu C.‐S. , Lin A. T. , Klaeschen D. , Klaucke I. , Chen L. , Hsu H.‐H. , Kunath P. , Elger J. , McIntosh K. D. , Feseker T. 
Published: January 2019

AbstractThe northern part of the South China Sea is characterized by widespread occurrence of bottom simulating reflectors indicating the presence of marine gas hydrate. Because the area covers both a tectonically inactive passive margin and the termination of a subduction zone, the influence of tectonism on the dynamics of gas hydrate systems can be studied in this region. Geophysical data show that there are multiple thrust faults on the active margin while much fewer and smaller faults exist in the passive margin. This tectonic difference matches with a difference in the geophysical characteristics of the gas hydrate systems. High hydrate saturation derived from ocean bottom seismometer data and controlled source electromagnetic data and conspicuous high‐amplitude reflections in P‐Cable 3‐D seismic data above the bottom simulating reflector are found in the anticlinal ridges of the active margin. In contrast, all geophysical evidence for the passive margin points to normal to low hydrate saturations. Geochemical analyses of gas samples collected at seep sites on the active margin show methane with heavy δ13C isotope composition, while gas collected at the passive margin shows light carbon isotope composition. Thus, we interpret the passive margin as a typical gas hydrate province fueled by biogenic production of methane and the active margin gas hydrate system as a system that is fueled not only by biogenic gas production but also by additional advection of thermogenic methane from the subduction system.
Negative cross-resistance between structurally different Bacillus thuringiensis toxins may favor resistance management of soybean looper in transgenic Bt cultivars
Authors: Rodrigues-Silva Nilson , Canuto Afonso F. , Oliveira Diogo F. , Teixeira André F. , Santos-Amaya Oscar F. , Picanço Marcelo C. , Pereira Eliseu J. G. 
Published: January 2019

AbstractHigh adoption rates of single-gene Bacillus thuringiensis (Bt) Cry1Ac soybean impose selection pressure for resistance in the soybean looper, Chrysodeixis includens, a major defoliator in soybean and cotton crops. To anticipate and characterize resistance profiles that can evolve, soybean looper larvae collected from field crops in Brazil in 2013 were selected for resistance to Cry1Ac. Using two methods of selection viz., chronic exposure to Cry1Ac cotton leaves and the seven-day larval exposure to purified Cry1Ac on the artificial diet, 31 and 127-fold resistance was obtained in 11 and 6 generations of selection, respectively. The resistance trait had realized heritability of 0.66 and 0.72, respectively, indicating that most of the phenotypic variation in Cry1Ac susceptibility of the soybean looper larvae was due to additive genetic variation. The Cry1Ac-selected populations showed positive cross-resistance to Cry1Ab (6.7–8.7 fold), likely because these Bt toxins have a very similar molecular structure. Importantly, the Cry1Ac-selected populations became more susceptible to Cry2Aa and Cry1Fa, showing negative cross-resistance (up to 6-fold, P < 0.05). These results indicate that Cry1Ac, Cry1Fa, and Cry2A are compatible in a multi-toxin approach to minimize the risk of rapid adaptation of the soybean looper to Bt toxins.
Crystal structure of the multidrug resistance regulator RamR complexed with bile acids
Authors: Yamasaki Suguru , Nakashima Ryosuke , Sakurai Keisuke , Baucheron Sylvie , Giraud Etienne , Doublet Benoît , Cloeckaert Axel , Nishino Kunihiko 
Published: January 2019

AbstractDuring infection, Salmonella senses and responds to harsh environments within the host. Persistence in a bile-rich environment is important for Salmonella to infect the small intestine or gallbladder and the multidrug efflux system AcrAB-TolC is required for bile resistance. The genes encoding this system are mainly regulated by the ramRA locus, which is composed of the divergently transcribed ramA and ramR genes. The acrAB and tolC genes are transcriptionally activated by RamA, whose encoding gene is itself transcriptionally repressed by RamR. RamR recognizes multiple drugs; however, the identity of the environmental signals to which it responds is unclear. Here, we describe the crystal structures of RamR in complexes with bile components, including cholic acid and chenodeoxycholic acid, determined at resolutions of 2.0 and 1.8 Å, respectively. Both cholic and chenodeoxycholic acids form four hydrogen bonds with Tyr59, Thr85, Ser137 and Asp152 of RamR, instead of π–π interactions with Phe155, a residue that is important for the recognition of multiple compounds including berberine, crystal violet, dequalinium, ethidium bromide and rhodamine 6 G. Binding of these compounds to RamR reduces its DNA-binding affinity, resulting in the increased transcription of ramA and acrAB-tolC. Our results reveal that Salmonella senses bile acid components through RamR and then upregulates the expression of RamA, which can lead to induction of acrAB-tolC expression with resulting tolerance to bile-rich environments.
Budding and Division of Giant Vesicles Linked to Phospholipid Production
Authors: Castro Juan M. , Sugiyama Hironori , Toyota Taro 
Published: January 2019

AbstractThe self-reproduction of supramolecular assemblies based on the synthesis and self-assembly of building blocks is a critical step towards the construction of chemical systems with autonomous, adaptive, and propagation properties. In this report, we demonstrate that giant vesicles can grow and produce daughter vesicles by synthesizing and incorporating phospholipids in situ from ad-hoc precursors. Our model involves acyl chain elongation via copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition reaction and the ensuing production of synthetic phospholipids to induce budding and division. In addition, the growth and budding of giant vesicles were compatible with the encapsulation and transfer of macromolecules as large as lambda phage DNA to the buds. This chemical system provides a useful model towards the implementation of cell-like compartments capable of propagation and transport of biological materials.