bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of Biogenesis and Fusion/Fission Processes of Vascular Mitochondria In Aldosterone-Induced Hypertension
Authors: Olivares-Álvaro Elena , Ruiz-Roso María Belén , Klett-Mingo Mercedes , Ballesteros Sandra , Gredilla Ricardo , Galiana-Simal Adrián , de las Heras Natalia , Lahera Vicente , Martín-Fernández Beatriz 
Published: December 2018

Background:Aldosterone plays a key role in the development of endothelial dysfunction and hypertension. The regulation of biogenesis and fusion/fission processes of vascular mitochondria has not been examined in aldosterone-induced hypertension. Thereby, we sought to explore in greater depth the role of aldosterone in mitochondrial biogenesis and fusion/fission processes in hypertension and the associated increases in oxidative stress.Methods:Male Wistar rats received aldosterone (1mg/Kg/day) + 1% NaCl as drinking water for 3 weeks.Results:Systolic blood pressure was elevated (p<0.05) in aldosterone-treated rats. eNOS and p-eNOSSer1177protein expression was down regulated (p<0.05) and NADPH oxidase subunit p22phox expression was increased (p<0.05) in aldosterone-treated rats. Expression of mitochondrial biogenesis proteins SIRT1, PGC1α, PPARγ, and TFAM decreased (p<0.05) in aldosterone-treated rats. Protein expression of vascular DRP1, OMA1 and S-OPA1 up regulated (p<0.05) in aldosterone-treated rats. MFN1 and L-OPA1 (p<0.05) decreased in aldosterone-treated animals.Conclusion:The results showed that, in aldosterone-treated rats, hypertension is likely associated with increased oxidative stress in the aorta and with changes in the regulation of two key mitochondrial processes such as biogenesis and fusion/fission processes. The overall mitochondrial alterations observed in the study may play a role in aldosterone-derived vascular oxidative stress and hypertension.
Asymptotic Relative Efficiencies of the Score and Robust Tests in Genetic Association Studies
Authors: Yuan Ao , Fan Ruzong , Xu Jinfeng , Xue Yuan , Li Qizhai 
Published: December 2018

Introduction:The score statisticZ(θ)and the maximin efficient robust test statisticZMERTare commonly used in genetic association study, but according to our knowledge there is no formal comparison of them.Methods:In this report, we compare the asymptotic behavior ofZ(θ)andZMERT, by computing their Asymptotic Relative Efficiencies (AREs) relative to each other. Four commonly used ARE measures, the Pitman ARE, Chernoff ARE, Hodges-Lehmann ARE and the Bahadur ARE are considered. Some modifications of these methods are made to simplify the computations. We found that the Chernoff, Hodges-Lehmann and Bahadur AREs are suitable for our setting.Results and Conclusion:Based on our study, the efficiencies of the two test statistic varies for different criterion used, and for different parameter values under the same criterion, so each test has its advantages and dis-advantages according to the criterion used and the parameters involved, which are described in the context. Numerical examples are given to illustrate the use of the two statistics in genetic association study.
STUDENT’S MATHEMATICAL VALUE IN MATHEMATICS LEARNING USING NON-ROUTINE PROBLEM
Authors: Safura Nurul Ain , Aisyah Nyimas , Hiltrimartin Cecil , Indaryanti Indaryanti 
Published: December 2018

Abstract: This study aims to determine the ability of students in solving non-routine problems in learning mathematics in high school. The focus of the study is the ability of students in solving non-routine problems that include the value of objectism, value of control, value of mystery, value of progress, value of rationalism, and value of openness. The subject of this study was determined purposively, that was based on the diversity of answers. The selected subject was six students of class X SMA in Palembang. The data were collected using observation, test, and interview which were then analyzed descriptively. The results show that in general the ability of students in solving non-routine problems is dominated by the value of objectism, control, rationalism, and progress. The other two values which did not dominantly appear were mystery and openness. Keywords: mathematical value, non-routine problemNILAI MATEMATIKA (MATHEMATICAL VALUE) SISWA PADA PEMBELAJARAN MATEMATIKA MENGGUNAKAN SOAL NON RUTIN Abstrak: Penelitian ini bertujuan untuk mengetahui kemampuan siswa dalam menyelesaikan soal non rutin pada pembelajaran matematika di SMA. Fokus penelitian adalah kemampuan siswa dalam menyelesaikan soal non rutin yang meliputi nilai objektisme, nilai kontrol, nilai misteri, nilai kemajuan, nilai rasionalisme, dan nilai keterbukaan. Adapun subjek penelitian ini dipilih secara purposive, berdasarkan keberagaman jawaban. Subjek yang terpilih adalah enam orang siswa kelas X SMA di Palembang. Data dikumpulkan menggunakan observasi, tes, dan juga wawancara, yang kemudian di analisis secara deskriptif. Hasil penelitian menunjukkan bahwa secara umum kemampuan siswa dalam menyelesaikan soal non rutin masih didominasi pada nilai objektisme, nilai kontrol, nilai rasionalisme, dan nilai kemajuan. Dua nilai lain yang tidak dominan muncul adalah nilai misteri dan nilai keterbukaan.Kata Kunci: nilai matematika, soal non rutin
TRANSFORMATIVE EDUCATION AS A DIALECTIC OF INDONESIAN CULTURE AND MODERN CULTURE
Authors: Rochmat Saefur 
Published: December 2018

Abstract:Indonesia has being an independent state more than 73 year, but it is not yet a modern state. It is due to a lack of continuity between Indonesian culture (in the forms of local cultures and religions) and modern culture. National culture, in the form of Pancasila state, is not similar to the original Indonesian culture as it is a mix of Indonesian culture and modern culture. This article is to elaborate transformative education which will synergize Indonesian culture and modern culture.This article is a kind of qualitative research, using observation and literature study methods. It focuses on the immaterial aspects of culture, namely supra-structure of both Indonesian culture and the modern one. Curriculum 2013 Revised that discards religious skills from all subjects, except Religious Education and Civic Education, reflects that government has not yet formulated clearly the national education system. National education should be transformative that enables to synergize the Indonesian culture to the modern one. Keywords:Indonesian culture, modern culture, religious skills, Pancasila PENDIDIKAN TRANSFORMATIF SEBAGAI DIALEKTIKA KEBUDAYAAN ASLI DENGAN KEBUDAYAAN MODERN Abstrak:Setelah merdeka lebih 73 tahun, Indonesia masih belum menjadi negara modern.Hal itu terjadi karena adanya kesenjangan antara kebudayaan lama dengan kebudayaan modern. Kebudayaan nasional dalam bentuk kebudayaan Pancasila tidak sepenuhnya merupakan kelanjutan kebudayaan asli sehingga Indonesia harus melakukan transformasi budaya. Artikel ini akan membahas pendidikan transformatif, yang akan mendialektikakan kebudayaan asli dengan kebudayaan modern.Artikel ini merupakan hasil penelitian kualitatif, yang dilakukan dengan metode observasi dan studi pustaka. Penelitian ditekankan pada aspek immaterial (suprastruktur), yang menjadi fondasi bagi struktur kebudayaan, baik dalam kebudayaan Indonesia maupun kebudayaan modern. Pendidikan transformatif merupakan pendidikan yang mampu mensinergikan suprastruktur kebudayaan asli (kebudayaan daerah dan agama) dengan suprasturktur kebudayanaan modern. Aspek suprastruktur kebudayaan asli tercermin dalam sila ke-1 yang bersifat religius, sedangkan aspek suprastruktur kebudayaan modern tercermin dalam sila ke-2, 3, 4, dan 5 yang sifatnya rasional. Kedua karakteristik ilmu itu harus menyatu dalam materi pelajaran yang diajarkan di sekolah, yang tercermin dalam religious skills. Kata kunci: kebudayaan asli, kebudayaan modern, religious skills, Pancasila
DOES PROBLEM-BASED LEARNING IMPROVE CRITICAL THINKING SKILL?
Authors: Narmaditya Bagus Shandy , Wulandari Dwi , Sakarji Siti Rosnita Binti 
Published: December 2018

Abstract: The study aims to understand the implementation of Problem-Based Learning and its impact on critical thinking skills for senior high school students. The study used the lesson study approach that was conducted in four cycles. Each learning activity consisted of identifying topic, presenting the report, and evaluating the Problem-Based Learning. The subject of the study was in a Senior High School in Malang, Indonesia. The level of critical thinking refers to Structure Observed Learning Outcome (SOLO) Taxonomy, consisting of Prestructural, Unistructural, Multistructural, Relational, and Extended Abstract thinking levels. The findings in the learning process show that the students’ critical thinking skills has increased. It is revealed by improving the ability to solve problems and making conclusions through critical thinking processes. The implementation of Problem-Based Learning also encourages students to think critically in the form of questioning, discussing problems and making solutions related to the employment issues, national income and economic growth in Indonesia. Keywords: Problem-Based Learning, Critical Thinking Skills, Lesson Study APAKAH PROBLEM-BASED LEARNING DAPAT MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS? Abstrak: Penelitian ini bertujuan untuk mengetahui penerapan Problem-Based Learning dan pengaruhnya terhadap kemampuan berpikir kritis pada siswa sekolah menengah atas. Penelitian ini menggunakan pendekatan lesson study yang dilakukan melalui empat siklus. Setiap aktivitas pembelajaran terdiri dari mengindentifikasi permasalahan, mempresentasikan laporan kegiatan, dan mengevaluasi pelaksanaan Problem-Based Learning. Subject penelitian ini dilakukan pada sebuah Sekolah Menengah Atas di Malang, Indonesia. Tingkat kemampuan berpikir kritis siswa dalam penelitian ini mengacu pada taksonomi SOLO (Structure Observed Learning Outcome) yang meliputi prastruktural, Unistruktural, Multistruktural, Relasional, and Extended Abstract. Hasil penelitian ini menunjukkan bahwa selama proses pembelajaran, kemampuan siswa dalam berpikir kritis telah meningkat. Hal ini ditunjukkan dari peningkatan kemampuan menyelesaikan masalah dan membuat kesimpulan melalui proses berpikir kritis. Penerapan Problem-Based Learning juga mendorong siswa memiliki kemampuan berpikir kritis dalam berbagai aktivitas seperti mengajukan pertanyaan, mendiskusikan permasalahan, dan membuat solusi terkait permasalahan pengangguran, pendapatan nasional, pertumbuhan ekonomi di Indonesia. Kata Kunci: Problem-Based Learning, Kemampuan Berpikir Kritis, Lesson Study
NASIONALISME DAN REVOLUSI: PENGALAMAN INDONESIA
Authors: Aman Aman - 
Published: December 2018

Abstract Nasionalisme dalam dimensi historisitas dan normativitas, merupakan sebuah penemuan sosial yang paling menakjubkan dalam perjalanan sejarah manusia, paling kurang dalam dasa warsa seratus tahun terakhir. Tidak ada satu pun ruang geografis-sosial di muka bumi yang lepas sepenuhnya dari pengaruh ideologi ini. Tanpa ideology nasionalisme, dinamika sejarah manusia akan berbeda sama sekali. Berakhirnya Perang Dingin dan semakin merebaknya konsepsi dan arus globalisme (internasionalisme) pada dekade 1990-an hingga sekarang, khususnya dengan adanya teknologi komunikasi dan informasi yang berkembang dengan sangat pesat, tidak dengan serta-merta membawa keruntuhan bagi nasionalisme. Sebaliknya, medan-medan ekspresi konsepsi nasionalisme menjadi semakin intensif dalam berbagai interaksi dan komunikasi sosial, politik, kultur, dan bahkan ekonomi internasional, baik di kalangan negara maju, seperti Amerika Serikat, Jerman, dan Perancis, maupun di kalangan negara Dunia Ketiga, seperti India, China, Malaysia, dan Indonesia. Nasionalisme tetap menjadi payung social-kultur negara-negara manapun untuk mengukuhkan integritasnya.
THE REFUSAL AGAINST 1925 TEACHER ORDINANCE IN WEST SUMATRA: ITS CONDITIONS, COURSE, AND AFTERMATH
Authors: Zara Muhammad Yuanda 
Published: December 2018

Worried with the rise of modernist Muslim movement coming from the Middle East, in 1925 Netherlands Indies Government issued and applied Teacher Ordinance (Goeroe Ordonnantie) in several regions in Netherlands Indies. It stipulated, among others, that every Muslim teacher must report himself to district head so that the district head could immediately issue a letter of identification, that Islamic teachers must keep the list of their students and religious subjects given to them, and the situation in which the right of teaching would be canceled, for example if the Islamic teachers provoke their students to condemn the Government. The Ordinance had been successfully applied and the Government planned to extend it to other regions, including West Sumatra. Yet, the majority of Islamic teachers throughout West Sumatra refused the plan. The refusal against 1925 Teacher Ordinance, in the form of mass demonstration and negotiation, influenced almost all of Islamic teachers in West Sumatra and reduced existing social and religious gaps in Minangkabau society due to the same feeling of dissatisfaction. Eventually, the Government canceled the application plan of the Ordinance in West Sumatra, showing the effectiveness of the social movement organized by Islamic teachers in West Sumatra.
Keywords: Teacher Ordinance, social movement, Islamic teachers, West Sumatera, Islam and colonialism
Comparative analysis of genotypes of Helicobacter pylori strains in the Rostov and Astrakhan regions
Authors: Sorokin V. M. , Pisanov R. V. , Vodop’janov A. S , Golubkina E. V. , Bereznjak E. A. 
Published: December 2018

Objective:to study the infection of the adult and children’s population of the Rostov and Astrakhan regions by the bacteria Helicobacter pylori, to determine the frequency of H. pylori pathogenicity factors in diﬀerent age groups of the population.Materials and methods:118 adults and 112 children were examined. Te presence of H. pylori DNA and the pathogenicity factors of CagA and VacA in the biopsy material of the mucous membrane of the antrum of the stomach was determined by PCR.Results:a signifcantly smaller percentage of H. pylori–positive patients is characteristic of the child population. Te prevalent H. pylori genotype in the infant population is the avirulent genotype Vac s2m2 (60%) (χ2: p <0.005). Genotype CagA + VacAs1 VacAm1 is a marker of peptic ulcer for adult population of the Rostov region.Conclusion:Te conducted studies allowed to establish diﬀerences in infection of the population with H. pylori bacteria and the frequency of the distribution of virulent genotypes depending on the region, age and severity of the pathology.
Incorporating Software Curation into Research Data Management Services: Lessons Learned
Authors: Rios Fernando 
Published: December 2018

Many large research universities provide research data management (RDM) support services for researchers. These may include support for data management planning, best practices (e.g., organization, support, and storage), archiving, sharing, and publication. However, these data-focused services may under-emphasize the importance of the software that is created to analyse said data. This is problematic for several reasons. First, because software is an integral part of research across all disciplines, it undermines the ability of said research to be understood, verified, and reused by others (and perhaps even the researcher themselves). Second, it may result in less visibility and credit for those involved in creating the software. A third reason is related to stewardship: if there is no clear process for how, when, and where the software associated with research can be accessed and who will be responsible for maintaining such access, important details of the research may be lost over time.
This article presents the process by which the RDM services unit of a large research university addressed the lack of emphasis on software and source code in their existing service offerings. The greatest challenges were related to the need to incorporate software into existing data-oriented service workflows while minimizing additional resources required, and the nascent state of software curation and archiving in a data management context. The problem was addressed from four directions: building an understanding of software curation and preservation from various viewpoints (e.g., video games, software engineering), building a conceptual model of software preservation to guide service decisions, implementing software-related services, and documenting and evaluating the work to build expertise and establish a standard service level.
Koroner arter hastalığında SYNTAX skorunun yeri
Authors: BAĞCI Ali 
Published: December 2018

Kardiyovasküler
hastalıklar ülkemizde ve gelişmiş ülkelerde mortalite ve morbiditenin en önemli
nedenidir. Kardiyovasküler hastalıklar arasında en yaygın olanı ise Koroner
Arter Hastalığı (KAH) olup yüksek mortalite ve morbidite ile ilişkilidir. Koroner arter hastalığının %99’unda etyolojik neden aterosklerozdur. Ateroskleroz
nedeniyle oluşan KAH ciddiyetini belirlemede altın standart yöntem koroner
anjiyografidir. Koroner anjiyografi hem tanı hem de tedavi yöntemidir. Bu
nedenle anjiyografi görüntülerine dayalı bazı skorlama sistemleri
geliştirilmiştir. SYNTAX skoru (SYNergy
between PCI with TAXUS and Cardiac Surgery) koroner arter hastalığının anatomik
ciddiyetini derecelendirmede kullanılan skorlama sistemlerinden biridir. Bu derlemede
koroner arter hastalığında SYNTAX skoru kullanımının incelenmesi ve
literatürünün güncel bilgilerle özetlenmesi amaçlanmıştır.
NONLINEAR ANALYSIS OF STATICALLY INDETERMINATE WOODEN STRUCTURES AND OPTIMIZATION OF CROSS SECTION DIMENSIONS OF DOME RIBS
Authors: Pyatikrestovsky Konstantin P. , Sokolov Boris S. 
Published: December 2018

The analysis of the behaviour of natural structures of laminated wood domes and the numerous preliminary calculations have shown the possibility of saving materials by reducing the height of cross sections of meridional ribs. This is especially effective when you include in design of skins, performing a role of building shell, the collaboration with frame elements (annular and longitudinal ribs). Multiple static indeterminacy of such structure allows its non-linear work and the redistribution of forces under nonuniform loads. At the same ime, the skin carries a significant part of the forces appearing in the shell and the ribs are underloaded. The tress-strain states of all elements are investigated. For the frame analysis the calculation is performed by the method of integral module that allows controlling strength resistance of a structure at any moment of its operation. The design recommendations for section dimensions of a shell are developed.
FUNDAMENTAL ERROR OF THE THEORY OF DURABLE RESISTENCE AND STANDARDS FOR REINFORCED CONCRETE
Authors: Sanzharovsky Rudolf S. , Ter-Emmanuilyan Tatyana N. , Manchenko Maxim M. 
Published: December 2018

This article identifies and investigates the errors in the foundations of the modern theory of creep of reinforced concrete caused by the use of the principle of superposition, which is an extensive interpretation of the principle (scheme) of the linear superposition of Boltzmann. The results of the analysis published by the authors in the journal of Structural Mechanics of Engineering Constructions and Buildings No. 6 of 2017 and No. 3 of 2016 are supplemented. The article was written in accordance with the recommendations of the round table held in the RUDN University on June 9, 2016, under the guidance of D.Sc., prof. Krivoshapko S.N.
THE GENERALIZED BIFRACTIONAL BROWNIAN MOTION
Authors: El-Nouty Charles 
Published: December 2018

To extend several known centered Gaussian processes, we introduce a new centered Gaussian process, named the generalized bifractional Brownian motion. This process depends on several parameters, namely α > 0 , β>0 , 0<H<1 and 0<K≤1 . When K=1, we investigate its convexity properties. Then, when 2HK≤ 1, we prove that this process is an element of the QHASI class, a class of centered Gaussian processes, which was introduced in 2015
NATURE SIMILAR TECHNOLOGIES IN CONSTRUCTION INDUSTRY
Authors: Lesovik Valery S. , Zagorodnyuk Lilia Kh. , Glagolev Evgeny S. , Feduk Roman S. 
Published: December 2018

In modern conditions it is necessary to create high-tech, reliable and durable composites of a new generation with the required properties, and this requires qualitatively new approaches in the design, synthesis, operation, destruction and reuse of sources, that is based on the introduction of fundamentally new nature-similiar technologies. The great interest not only in Russia, but also abroad, present additive technologies. The article proposes the technology of using water-resistant and cold-resistant quick-hardening composite on the basis of gypsum binders of a new generation with finely ground mineral additives of different genetic types, in-cluding using a new unique type of mineral additives - waste from the magnetic separation of ferruginous quartzite. бионика, геоника (геомиметика), 3D-технологии, аддитивные технологии, композиционные гипсовые вяжущие, минеральная добавка, строительные композиты
Pengaruh Penggunaan Filter Butterworth pada Penentuan Waktu Tiba Gelombang P
Authors: Sriyanto Sesar Prabu Dwi 
Published: December 2018

PenentuanÂ waktu tibaÂ gelombang P cukup sulit dilakukan apabilaÂ sinyal memiliki Signal to Noise RatioÂ (SNR) rendah. Pemfilteran sinyal dapat dilakukan untuk meningkatkan SNR. Pemilihan rentang frekuensi filter harus sesuai dengan kandungan frekuensi gelombang gempabumi karenaÂ apabilaÂ tidak sesuai akan mendistorsiÂ fase gelombang P danÂ menyebabkan penentuan waktu tiba gelombang P tidak tepat. Pada penelitian ini dilakukan analisis pengaruh penggunaan 3 jenis filter Butterworth orde 5 pada waktu tiba gelombang P. Jenis filter Butterworth kausal yang digunakan yaitu, filter lowpass 2 Hz, bandpass 2-6 Hz, dan highpass 6 Hz. Hasilnya, secara umum penggunaan filter memberikan efek keterlambatan fase dan pelemahan impuls awal gelombang P yang menyebabkan kesalahan penentuan waktu tiba gelombang P. Jenis filter yang paling bagus digunakan adalah filter bandpass karena kesalahan penentuan waktu tiba gelombang P rata-rata 0.271 detik. Hal ini disebabkan karena gelombang P memiliki frekuensi dominan rata-rata 3.83 Hz. Sementara itu, pemfilteran dengan lowpass dan highpass rata-rata kesalahan masing-masing sebesar 2.183 detik dan 0.347 detik.
Linguistic Thoughts as The Basis of Arabic Learning Innovation
Authors: Thonthowi Thonthowi 
Published: December 2018

AbstractThis study aims to discuss linguistic thoughts and Arabic learning in Indonesia, along with both innovation opportunities and their actualization in the development of Arabic learning. This study is literary with an intertextual approach to the literature associated with two fields. The meaning of the text is done by content analysis. This study concludes that the innovation of linguistic thoughts and Arabic learning can be done on three levels, namely Arabic linguistic study and development, contextualization of Arabic research methodology, and standardization of ICT-based Arabic language learning and research. Various problems surrounding learning Arabic language can be solved through research and study of Arabic linguistics in depth, comprehensive and cross-disciplinary of science. Opportunities to innovate linguistic thoughts and language learning are wide open. Various scientific forums and journals as well as research in Arabic-based learning development of linguistic thought can lead to tajdîd (reform, innovation) and ijtihâdat lughawiyyah (linguistics innovation). The future of linguistic studies and Arabic learning in Indonesia is believed to be very bright and enlightening if reinforced by the development of linguistic research meth- ods and Arabic learning.Keywords:Innovation, linguistic thought, Arabic learning, linguistic research, scientific and academic forums