bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative hyponatremia is an independent predictor of one-year mortality after liver transplantation
Authors: Yang Seong-Mi , Choi Sheung-Nyoung , Yu Je Hyuk , Yoon Hyun-Kyu , Kim Won Ho , Jung Chul-Woo , Suh Kyung-Suk , Lee Kook Hyun 
Published: December 2018

AbstractPreoperative hyponatremia is associated with an increased risk of mortality on the liver transplantation (LT) waiting list. We sought to investigate the impact of pre- and intraoperative serum sodium levels on the one-year mortality after LT. We identified 1,164 patients for whom preoperative and intraoperative serum sodium levels were available. Cox regression analysis with multivariable adjustment was performed for one-year mortality. A propensity score matching analysis was performed for preoperative and intraoperative serum sodium groups to compare one-year survival. The cutoff of sodium level with minimal p-value was 130 mEq/L for both preoperative and intraoperative sodium. Intraoperative hyponatremia was an independent predictor of one-year mortality in the multivariable Cox regression analysis, while preoperative hyponatremia was not. Kaplan-Meier curve showed that there was a significant difference in the one-year mortality between preoperative and intraoperative serum sodium groups. However, after propensity score matching, there was no difference in the one-year mortality among the preoperative sodium groups, while there was a significant difference among the intraoperative sodium groups. Intraoperative hyponatremia defined by mean sodium <130 mEq/L was independently associated with a significantly high one-year mortality. Mean intraoperative serum sodium levels may be a better prognostic predictor than preoperative serum sodium levels.
Understanding cellular glycan surfaces in the central nervous system
Authors: Iqbal Sameera , Ghanimi Fard Mina , Everest-Dass Arun , Packer Nicolle H. , Parker Lindsay M. 
Published: December 2018

Abstract
Glycosylation, the enzymatic process by which glycans are attached to proteins and lipids, is the most abundant and functionally important type of post-translational modification associated with brain development, neurodegenerative disorders, psychopathologies and brain cancers. Glycan structures are diverse and complex; however, they have been detected and targeted in the central nervous system (CNS) by various immunohistochemical detection methods using glycan-binding proteins such as anti-glycan antibodies or lectins and/or characterized with analytical techniques such as chromatography and mass spectrometry. The glycan structures on glycoproteins and glycolipids expressed in neural stem cells play key roles in neural development, biological processes and CNS maintenance, such as cell adhesion, signal transduction, molecular trafficking and differentiation. This brief review will highlight some of the important findings on differential glycan expression across stages of CNS cell differentiation and in pathological disorders and diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, schizophrenia and brain cancer.
Learning RuBisCO's birth and subsequent environmental adaptation
Authors: Ashida Hiroki , Mizohata Eiichi , Yokota Akiho 
Published: December 2018

Abstract
It is believed that organisms that first appeared after the formation of the earth lived in a very limited environment, making full use of the limited number of genes. From these early organisms' genes, more were created by replication, mutation, recombination, translocation, and transmission of other organisms' DNA; thus, it became possible for ancient organisms to grow in various environments. The photosynthetic CO2-fixing enzyme RuBisCO (ribulose 1,5-bisphosphate carboxylase/oxygenase) began to function in primitive methanogenic archaea and has been evolved as a central CO2-fixing enzyme in response to the large changes in CO2 and O2 concentrations that occurred in the subsequent 4 billion years. In this review, the processes of its adaptation to be specialized for CO2 fixation will be presented from the viewpoint of functions and structures of RuBisCO.
The State and Civil Society: the case of Citizens’ Groups in the ger districts of Ulaanbaatar, Mongolia
Authors: Terbish Bayartsetseg , Rawsthorne Margot 
Published: December 2018

AbstractMongolia is a vast landlocked, sparsely populated, country which shares borders with China and Russia. Two decades of democratic government has coincided with rapid cultural, social, environmental and economic change marred by increasing inequality. Addressing the challenges of inequality demands meaningful engagement between state and non-state actors in the emergent democracy of Mongolia. This article focuses on research with Citizens’ Groups, semi-formal grassroots groups involved in community development in ger districts of Ulaanbaatar, the capital city. Drawing on research undertaken in 2017 with members of Citizens’ Groups and employed staff of Non-Government Organizations it explores the interaction between government (in the form of local government or Khoroo) and civil society (in the form of Citizens’ Groups). Data was collected via interviews, focus groups and site visits with over thirty people. Accordingly, the paper continues a focus on emerging community development practices in East Asia, a region both benefiting from and challenged by urbanization from rural to urban settings. The paper concludes that Citizens’ Groups are key to realizing the Government’s commitment to building social capital, social innovation and the social economy. To realize this goal, however further work is required to promote a democratic political culture, expand citizen participation and strengthen co-operation between the State and civil society.
Normal radiological lymph node appearance in the thorax
Authors: Hansen T , Nilsson M , Lindholm D , Sundström J , Hedberg J 
Published: December 2018

SUMMARY
Modern treatment of esophageal cancer is multimodal and highly dependent on a detailed diagnostic assessment of clinical stage, which includes nodal stage. Clinical appraisal of nodal stage is highly dependent on knowledge of normal radiological appearance, information of which is scarce. We aimed to describe lymph node appearance on computed tomography (CT) investigations in a randomly selected cohort of healthy subjects. In a sample of the Swedish Cardiopulmonary bioimage study, which investigates a sample of the Swedish population aged 50–64 years, the CT scans of 426 subjects were studied in detail concerning intrathoracic node stations relevant in clinical staging of esophageal cancer. With stratification for sex, the short axis of visible lymph nodes was measured and the distribution of lymph node sizes was calculated as well as proportion of patients with visible nodes above 5 and 10 millimeters for each station. Probability of having any lymph node station above 5 and 10 millimeters was calculated with a logistic regression model adjusted for age and sex. In the 214 men (aged: 57.3 ± 4.1 years) and 212 women (aged: 57.8 ± 4.4 years) included in this study, a total of 309 (72.5%) had a lymph node with a short axis of 5 mm or above was seen in at least one of the node stations investigated. When using 10 mm as a cutoff, nodes were visible in 29 (6.81%) of the subjects. Men had higher odds of having any lymph node with short axis 5 mm or above (OR 3.03 95% CI 1.89–4.85, P &lt; 0.001) as well as 10 mm or above (OR 2.31 95% CI 1.02–5.23, P = 0.044) compared to women. Higher age was not associated with propensity for lymph nodes above 5 or 10 millimeters in this sample. We conclude that, in a randomly selected cohort of patients between 50 and 64 years, almost 10% of the men and 4% of the women had lymph nodes above 10 millimeters, most frequently in the subcarinal station (station 107). More than half of the patients had nodes above 5 millimeters on CT and men were much more prone to have this finding. The probability of finding lymph nodes in specific stations relevant of esophageal cancer is now described.
Appropriate Treatment for Bloodstream Infections Due to Carbapenem-Resistant Klebsiella pneumoniae and Escherichia coli: A Nationwide Multicenter Study in Taiwan
Authors: Lin Yi-Tsung , Su Chin-Fang , Chuang Chien , Lin Jung-Chung , Lu Po-Liang , Huang Ching-Tai , Wang Jann-Tay , Chuang Yin-Ching , Siu L Kristopher , Fung Chang-Phone 
Published: December 2018

Abstract

Background
In a multicenter study from Taiwan, we aimed to investigate the outcome of patients who received different antimicrobial therapy in carbapenem-resistant Enterobacteriaceae bloodstream infections and proposed a new definition for tigecycline use.

Methods
Patients from 16 hospitals in Taiwan who received appropriate therapy for bloodstream infections due to carbapenem-resistant Klebsiella pneumoniae and Escherichia coli were enrolled in the study between January 2012 and June 2015. We used a cox proportional regression model for multivariate analysis to identify independent risk factors of 14-day mortality. Tigecycline was defined as appropriate when the isolates had a minimum inhibitory concentration (MIC) ≤0.5 mg/L, and we investigated whether tigecycline was associated with mortality among patients with monotherapy.

Results
Sixty-four cases with carbapenem-resistant K pneumoniae (n = 50) and E coli (n = 14) bloodstream infections were analyzed. Of the 64 isolates, 17 (26.6%) had genes that encoded carbapenemases. The 14-day mortality of these cases was 31.3%. In the multivariate analysis, Charlson Comorbidity Index (hazard ratio [HR], 1.21; 95% confidence interval [CI], 1.03–1.42; P = .022) and colistin monotherapy (HR, 5.57; 95% CI, 2.13–14.61; P &lt; .001) were independently associated with 14-day mortality. Among the 55 patients with monotherapy, the 14-day mortality was 30.9% (n = 17). Tigecycline use was not associated with mortality in the multivariate analysis.

Conclusions
Tigecycline monotherapy was a choice if the strains exhibited MIC ≤0.5 mg/L, and colistin monotherapy was not suitable. Our findings can initiate additional clinical studies regarding the efficacy of tigecycline in carbapenem-resistant Enterobacteriaceae infections.
Safety of Pleuroscopy Performed in Negative Pressure Bronchoscopy Rooms
Authors: Sagar A.S. , Eapen Georgie A. , Casal Roberto F. , Ost David , Sarkiss Mona , Grosu Horiana B. 
Published: December 2018

Background:
The use of pleuroscopy has expanded over the last decade due to its higher diagnostic yield and low complications rate. Whether the infectious complications of pleuroscopy performed in negative pressure rooms is similar to that of pleuroscopy performed in positive pressure rooms remain unclear. To assess the safety of pleuroscopy performed in negative pressure rooms, we sought to determine the rate of infectious complications in patients who underwent pleuroscopy in negative pressure bronchoscopy rooms at our institution.

Methods:
This was a retrospective cohort study of all patients who underwent pleuroscopy in our institution’s negative pressure bronchoscopy rooms between January 2005 and January 2018. The primary outcome was the incidence of infectious complications at 14 and 30 days after the procedure.

Results:
We identified 318 patients. Of the 318 patients, 47 (15%) had hematological malignancies, 118 (37%) had lung cancer, 121 (38%) had solid non–lung cancers, and 32 (10%) had no cancer diagnosis before the procedure. At the end of pleuroscopy, 255 patients (80%) had an indwelling pleural catheter placed, 63 patients (20%) had only a chest tube placed, and 31 patients (9%) had both an indwelling pleural catheter and chest tube placed. No patients developed empyema within 14 days. Three patients (0.9%) developed empyema within 30 days after the procedure and was presumed to be due to pleural catheter infection in all cases.

Conclusion:
Our findings show that pleuroscopy performed in negative pressure rooms has a low incidence of infectious complications, provided that proper sterile precautions are maintained.
Changes in Perceived Self-efficacy of Physical Therapist Students Following a Pediatric Experiential Learning Opportunity
Authors: Wolden Mitch , Anderson Brittany , Ray Chris 
Published: December 2018

Purpose:
Physical therapists (PT) must be competent to treat patients across the lifespan, from pediatrics through geriatrics. Increasing the amount of experiential learning (EL) in pediatrics presents an opportunity for students to improve their self-efficacy in communication and patient handling. The purpose was to investigate changes in PT students' perceived self-efficacy in communication and patient handling following a structured and focused 8-week EL opportunity with a pediatric population.

Methods:
Thirty-two PT students completed the Pediatric Communication and Handling Self-Efficacy Scale before and after an 8-week pediatric EL opportunity. A paired-samples t test was performed to assess changes in students' self-efficacy levels of communication and patient handling.

Results:
Perceived self-efficacy levels significantly improved in regard to students' communication and patient handling skills following a pediatric EL opportunity.

Conclusions:
Our findings reinforce the benefits of incorporating pediatric EL opportunities into the DPT curriculum as an effective learning strategy in pediatric education.
Progression of Ankle Plantarflexion Contractures and Functional Decline in Duchenne Muscular Dystrophy: Implications for Physical Therapy Management
Authors: Kiefer Michael , Bonarrigo Kelly , Quatman-Yates Catherine , Fowler Amanda , Horn Paul S. , Wong Brenda L. 
Published: December 2018

Purpose:
This study characterizes the progressive loss of ankle dorsiflexion range of motion in boys with Duchenne muscular dystrophy (DMD), the relationship to functional decline, and the implications for physical therapy management.

Methods:
Longitudinal data for 332 boys with DMD were extracted from medical records and analyzed. Summary statistics for age, number of visits, ankle dorsiflexion measures, and North Star Ambulatory Assessment (NSAA) scores were computed.

Results:
Ankle dorsiflexion motion ranged from −32.5 to 25 degrees. Progression of ankle contractures is demonstrated by a trend line: slope −1.43 per year. NSAA score was estimated to decline approximately 0.23 points per 1 degree of ankle dorsiflexion lost.

Conclusions:
The results of this study describe the progression of ankle contractures and functional decline in DMD. The findings may help inform decisions regarding interventions to support participants with DMD and their families.
Effects of Structured Exercise Training in Children and Adolescents With Juvenile Idiopathic Arthritis
Authors: Klepper Susan , Mano Khong Taryn Tamiko , Klotz Rachel , Gregorek Adrienne Odmark , Chan Y Chee , Sawade Samantha 
Published: December 2018

Purpose:
To examine safety and efficacy of exercise training (ET) for juvenile idiopathic arthritis (JIA) to improve physical fitness, pain, functional capability, and quality of life.

Methods:
Ovid Medline, PubMed, CINAHL, PEDro, and Web of Science were searched from 1995 to April 2018 to find English-language articles examining effects of ET in JIA, ages 4 to 21 years. Quality of evidence/strength of clinical recommendations were assessed using the Cochrane GRADE (Grading of Recommendations, Assessment, Development and Evaluation) system. Results were reported using the 2009 Preferred Reporting Items for Systematic Reviews and meta-Analyses (PRISMA) checklist for health care interventions.

Results:
Nine papers met inclusion criteria. A total of 457 individuals with JIA, ages 4 to 19.9 years, received ET or alternate activity, wait-list, or no intervention. Moderate-quality evidence supports Stott Pilates and underwater knee-resistance exercise. No adverse effects of ET were reported.

Conclusions:
Moderate-quality evidence exists for ET (30-50 minutes, 2-3 times/week, 12-24 weeks) to decrease pain, improve range of motion, knee strength, functional capability, and quality of life in JIA.
Pain neuroscience education on YouTube: a systematic review
Authors: Heathcote Lauren C. , Pate Joshua W. , Park Anna L. , Leake Hayley B. , Moseley G. Lorimer , Kronman Corey A. , Fischer Molly , Timmers Inge , Simons Laura E. 
Published: December 2018

AbstractObjectivesThe Internet in general, and YouTube in particular, is now one of the most popular sources of health-related information. Pain neuroscience education has become a primary tool for managing persistent pain, based in part on the discovery that information about pain can change pain. Our objective was to examine the availability, characteristics, and content of YouTube videos providing pain neuroscience education.MethodsWe conducted a systematic review of videos on YouTube using the search terms “pain education”, “what is pain”, and “pain brain” in January 2018. Videos were included if they were in English, were under 10 minutes long, and included information on the neuroscience of pain. Videos were coded for i) descriptive characteristics (e.g., number of views, duration on YouTube), ii) source and style, iii) whether or not they addressed seven pre-determined target concepts of pain neuroscience education (e.g., ‘Pain is not an accurate marker of tissue state’), and iv) how engaging they were.ResultsWe found 106 unique videos that met the inclusion criteria. The videos ranged from having four views to over five million views (Mdn = 1163 views), with the three most highly viewed videos accounting for 75% of the total views. Animated videos were much more highly viewed than non-animated videos. Only a small number of videos had been posted by a clearly-identifiable reputable source such as an academic or medical research institution (10%), although a number of videos were posted by healthcare professionals and professional medical societies. For a small number of videos (7%), the source was unclear. We found 17 videos that addressed at least one target concept of pain neuroscience science education, only nine of which were considered to be engaging. The target concept ‘Pain is a brain output’ was considered to be well addressed by the most videos (N = 11), followed by ‘Pain is a protector’ (N = 10). We found only one video that adequately addressed all seven target concepts of pain neuroscience education.DiscussionYouTube contains a variety of videos that practitioners, patients, and families may view to access pain neuroscience education information. A small portion of these videos addressed one or more target concepts of pain neuroscience education in an engaging manner. It is yet to be determined to what extent patients are able to learn information from these videos, to what extent the videos promote behavior change, and thus to what extent the videos may be useful for clinical practice.
Adaptation to developmental diet influences the response to selection on age at reproduction in the fruit fly
Authors: May Christina M. , van den Heuvel Joost , Doroszuk Agnieszka , Hoedjes Katja M. , Flatt Thomas , Zwaan Bas J. 
Published: December 2018

AbstractExperimental evolution (EE) is a powerful tool for addressing how environmental factors influence life-history evolution. While in nature different selection pressures experienced across the lifespan shape life histories, EE studies typically apply selection pressures one at a time. Here we assess the consequences of adaptation to three different developmental diets in combination with classical selection for early or late reproduction in the fruit fly Drosophila melanogaster. We find that the response to each selection pressure is similar to that observed when they are applied independently, but the overall magnitude of the response depends on the selection regime experienced in the other life stage. For example, adaptation to increased age at reproduction increased lifespan across all diets, however, the extent of the increase was dependent on the dietary selection regime. Similarly, adaptation to a lower calorie developmental diet led to faster development and decreased adult weight, but the magnitude of the response was dependent on the age-at-reproduction selection regime. Given that multiple selection pressures are prevalent in nature, our findings suggest that trade-offs should be considered not only among traits within an organism, but also among adaptive responses to different - sometimes conflicting - selection pressures, including across life stages.
Disentangling the origins of confidence in speeded perceptual judgments through multimodal imaging
Authors: Pereira Michael , Faivre Nathan , Iturrate Iñaki , Wirthlin Marco , Serafini Luana , Martin Stéphanie , Desvachez Arnaud , Blanke Olaf , Ville Dimitri Van De , Millán José del R. 
Published: December 2018

AbstractThe human capacity to compute the likelihood that a decision is correct - known as metacognition - has proven difficult to study in isolation as it usually co-occurs with decision-making. Here, we isolated post-decisional from decisional contributions to metacognition by combining a novel paradigm with multimodal imaging. Healthy volunteers reported their confidence in the accuracy of decisions they made or decisions they observed. We found better metacognitive performance for committed vs. observed decisions, indicating that committing to a decision informs confidence. Relying on concurrent electroencephalography and hemodynamic recordings, we found a common correlate of confidence following committed and observed decisions in the inferior frontal gyrus, and a dissociation in the anterior prefrontal cortex and anterior insula. We discuss these results in light of decisional and post-decisional accounts of confidence, and propose a generative model of confidence in which metacognitive performance naturally improves when evidence accumulation is constrained upon committing a decision.