bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bisphosphonate-associated Osteonecrosis of the Jaws: a Survey of the Level of Knowledge of Dentists about the Risks of Bisphosphonate Therapy
Authors: Hristamyan-Cilev Meri A. , Pechalova Petya P. , Raycheva Ralitsa D. , Hristamyan Veselka P. , Kevorkyan Ani K. , Stoilova Yordanka D. 
Published: July 2019

Abstract
Introduction: Bisphosphonate-associated osteonecrosis of the jaws (BAONJ) is a side effect of treatment with bisphosphonate (BP). Reports of this complication have increased recently.
Aim: To evaluate the level of knowledge of dentists from Plovdiv, Bulgaria, about possible complications of bisphosphonate therapy of patients in dental practice.
Materials and methods: Three hundred and twenty-three dental practitioners from Plovdiv, Bulgaria, took part in an anonymous survey containing 25 questions, designed to evaluate the knowledge of dentists about the complications of BP therapy.
Results: Oral and maxillofacial surgeons have the best knowledge about the indications and side effects of BP therapy, while dentists with a specialty in Pediatric Dentistry and General Dentistry have insufficient knowledge. Of the respondents, 17.03% are absolutely uninformed about BP and their side effects, and 1/2 declare that they have never had a patient with complications from BP therapy in their practice, probably due to a lack of awareness of the problem. Approximately half of the dentists we surveyed agree to carry out prophylactic examinations of patients receiving BP and know what the prophylactic examination includes. Only 15.48% of the respondents have correctly responded that in order to be treated as clinically healthy, patients should have stopped taking BP for more than 10 years.
Conclusion: With the exception of specialists in Oral and Maxillofacial Surgery, dental practitioners in Plovdiv and the region are poorly informed about the complications associated with BP therapy. Therefore, efforts must be made to make these dentists better informed about BAONJ, especially about the methods and means of preventing this condition.
Trends in the Acute Hepatitis B and Acute Hepatitis C in Bulgaria
Authors: Baymakova Magdalena P. , Karcheva Milena 
Published: July 2019

Abstract
Introduction: Bulgaria joined European Union (EU) on 1 January 2007. Since the accession all regulations, directives, decisions, recommendations, and opinions of the European Parliament, the Council of the European Union, and the European Commission are being implemented.
Aim: The purpose of this study was to present the morbidity of acute hepatitis B virus (HBV) and acute hepatitis C virus (HCV) in Bulgaria before and after accession to the EU.
Materials and methods: A retrospective study was performed. The morbidity of acute HBV and acute HCV infections in Bulgaria was analyzed over a period of sixteen years (2000−2016). The collected data were based on the National Center of Infectious and Parasitic Diseases (NCIPD) and the National Center of Public Health and Analyses (NCPHA).
Results: Between 2000 and 2016, 11038 cases of acute HBV infection and 1681 cases of acute HCV infection were reported in Bulgaria. Before the accession to EU, the morbidity rates of acute HBV and acute HCV infections were 12.77 cases per 100 000 population (95% CI: 11.45–13.97) and 1.52 cases per 100 000 population (95% CI: 1.17–1.96), respectively. After the accession to the EU, the morbidity rates of acute HBV and acute HCV infections were 5.29 cases per 100 000 population (95% CI: 3.86–6.73) and 1.14 cases per 100 000 population, respectively.
Conclusion: Analysis of the data suggests that there is a tendency for lower morbidity rates of acute HBV. The situation with acute HCV is relatively stable over the years regardless of EU membership.
Thyroid Gland as a Target of Secondary Malignancies - an Autopsy Study and Review Data
Authors: Mistelou Antigony , Papadatos Stamatis S. , Kousi Chrysavgi , Lampri Evangeli , Mitsis Michael , Vougiouklakis Theodoros , Galani Vasiliki 
Published: July 2019

Abstract
Aim: Secondary malignancies of the thyroid gland are rarely diagnosed but their incidence at autopsy is not uncommon.
Materials and methods: To investigate the clinicopathological features of patients with metastatic tumours of the thyroid gland, we reviewed autopsy records and pathological features of 36 cases with thyroidal secondary tumours from 266 cases of malignant neoplasias (excluding cases of primary thyroid cancer), over a 16-year period.
Results: There were 19 men and 17 women in the study, ranging in age from 37 to 95 years (mean 70.4 years). The incidence of metastasis in thyroid gland was 0.9% in all autopsy cases, and 13.53% of the malignant tumours. The majority were carcinomas of epithelial origin. The lung was the most common primary tumour site (33.3%), followed by the breast (8.33%) and the kidney (8.33%). The most common non-epithelial malignancy was lymphoma, followed by leukaemia (total of both 25%). As for the microscopic morphological observations, diffuse infiltration pattern of tumour cells was noted in 63.89% of the cases, the formation of nodules in 33.33% of the cases and contiguous invasion in 2.79% of the cases. There were 35.71% cases of metastases associated with multinodular goitre and 28.57% cases associated with papillary microcarcinoma.
Conclusion: Our study indicates that thyroid secondary malignancies are not infrequent and may constitute a diagnostic problem. Lung cancer is the most common neoplasm that metastasizes to the thyroid gland in north-western Greek population.
Genetics of Thyroid Disorders
Authors: Cortés Jessica María Rodríguez , Zerón Hugo Mendieta 
Published: July 2019

Abstract
Background: Thyroid diseases are the most common endocrine pathologies second to diabetes. They have been shown to have high genetic impact, and variants in any of the genes involved in the metabolism of thyroid hormones have marked influence on the development of these diseases.
Aim: To identify the genes that have been most involved in the development of thyroid pathologies by reviewing the literature with recent relevant articles.
Materials and methods: We performed a literature search on the NCBI (National Center for Biotechnology Information) databases, and that of the European Bioinformatics Institute (EMBL-EBI) using keywords related to the topic of interest).
Results: Activation of oncogenes such as RAS, BRAF, RET/PTC and the overstimulation of the PI3K/AKT pathway plays an important role in thyroid tumorigenesis. SLC5A5, SLC26A4, TG, TPO, DUOX2, DUOXA2 are related to hypothyroidism. Risk factors for Graves’ disease are associated with the presence of HLA-DR3, CTLA4, PTPN22, CD40, IL2RA (CD25), FCRL3, and IL23R. FOXE1 can be associated to hypothyroidism and papillary thyroid cancer.
Conclusions: Thyroid diseases are polygenetic, and while there are sufficient pathways affected by genetic changes, and there is, to our knowledge, no gene that has been found to be specifically causal, and the pathology has been the result of the interaction of many genetic variables such as polymorphisms or mutations.
Desaturation during Physical Exercise in COPD Patients – a Stable-over-time Phenomenon
Authors: Kalinov Roman I. , Marinov Blagoi I. , Stoyanova Dimitrina I. , Hodgev Vladimir A. , Vladimirova-Kitova Lyudmila G. , Nikolov Fedya P. , Kostianev Stefan S. 
Published: July 2019

Abstract
Introduction: Exercise-induced desaturation is a common finding in patients with moderate and severe COPD. It is an important marker in the course of disease that has a prognostic value for mortality risk.
Aim: To monitor over time COPD patients with and without desaturation during 6-minute walking test (6MWT) and to assess the stability of that phenomenon.
Materials and methods: A 6MWT was administered to 70 patients with COPD which ranged in severity from stage 2A to stage 4D (GOLD 2011); the patients had a mean age of 64.5±10.1, mean pack-years - 38.8±21, FEV1% = 46.4%±15.7%, FVC% = 73.7%±1.3%, MRC = 2.31±0.84, CAT = 20.8±6.6. Oxygen saturation was monitored during the test; indications for desaturation were a decrease of SpO2 by ≥4% and a fall in SpO2 to ≤88% for at least 3 min. The patients were followed-up for mean 40.9±22.3 months and tests were repeated.
Results: Patients were divided into two groups based on the decrease in SpO2: Group A included patients with desaturation (n=35) and Group B – patients with no desaturation (n=35). In 66 of the patients the desaturation profile was stable over time. Only two patients, who did not desaturated at baseline, experienced desaturation in the follow-up 6MWT and another two patients, who desaturated at baseline, did not have it later in the follow-up.
Conclusion: Desaturation is a phenomenon that is persistent over time. Based on the results, it could be concluded that exercise-induced desaturation is a major marker of a particular COPD phenotype.
Anatomical Variations of the Musculocutaneous and Median Nerves: A Case Report
Authors: Darvishi Marzieh , Moayeri Ardeshir 
Published: July 2019

Abstract
The musculocutaneous nerve is a large terminal branch of the lateral cord of the brachial plexus. It passes under the pectoralis minor and penetrates the coracobrachialis muscle, descending between the biceps brachii and brachialis muscles in the arm. After dissection in upper extremities in a 28-year-old male cadaver, the median and musculocutaneous nerve were found to have variations on the right side where the musculocutaneous nerve formed communications with the median nerve. The median nerve innervated muscles of the front of the arm in this cadaver. In addition, the musculocutaneous nerve did not pierce the coracobrachialis muscle on the right side. Knowledge of these variations is extremely important when planning a surgery in the region of axilla.
Comparison of the Safety and Efficacy of Intravitreal Ranibizumab with or without Laser Photocoagulation Versus Dexamethasone Intravitreal Implant with or without Laser Photocoagulation for Macular Edema Secondary to Branch Retinal Vein Occlusion
Authors: Kumar Prashant , Sharma Yog Raj , Chandra Parijat , Azad Rajvardhan , Meshram Girish Gulab 
Published: July 2019

Abstract
Background: There is an ambiguity regarding the therapy of choice for patients with macular edema following branch retinal vein occlusion (BRVO).
Aim: The purpose of the study was to compare the efficacy and safety of ranibizumab (3 injections 0.5 mg) versus ranibizumab (1 injection 0.5 mg) with laser photocoagulation (LP) versus dexamethamethasone intravitreal (IVT) implant (0.7 mg) with or without LP in patients with macular edema following BRVO.
Materials and methods: 60 eyes of 60 patients were divided into 4 groups. Group 1 received IVT ranibizumab (3 injections 0.5 mg), Group 2 received IVT ranibizumab (1 injection 0.5 mg) + LP, Group 3 received dexamethasone IVT implant (0.7 mg), and Group 4 received dexamethasone IVT implant (0.7 mg) + LP. The endpoints were the difference in mean changes in best corrected visual acuity (BCVA), central macular thickness (CMT), and inter-group differences in contrast sensitivity (CS), retinal sensitivity (RS), and intraocular pressure (IOP).
Results: BCVA gains in Group 1 (18.00±8.51) patients were significantly (p < 0.05) higher than patients in Groups 2 (10.00±10.26), 3 (9.50±9.60), and 4 (10.50±10.97), after 6 months of therapy. No significant inter-group variation was found in the CMT, CS, and RS.
Conclusions: Ranibizumab (3 injections 0.5 mg) showed significantly higher BCVA gains at 6 months post-therapy. Improvements in the BCVA, CMT, CS, and RS were comparable initially in all the therapies.
Evaluation of Kidney Function Parameters in Diabetic Rats Following Virgin Coconut Oil Diet
Authors: Akinnuga Akinjide M. , Bamidele Olubayode , Adewumi Anthony J. 
Published: July 2019

Abstract
Background: Diabetes mellitus (DM) leads to disruption of kidney function parameters (KFPs) which are markers of kidney diseases, especially nephropathy. Virgin coconut oil (VCO) has been implicated in playing a significant role in DM management. However, its role on KFPs in DM is scarce.
Aim: To evaluate the kidney function parameters following VCO diet in diabetic rats.
Materials and methods: : Twenty-five (25) male rats of 150 – 200 g were divided into 5 groups (n=5): Non-diabetic control (Group 1), diabetes control (Group 2), diabetes + metformin (Group 3), diabetes + 10% VCO (Group 4) and diabetes + 20% VCO (Group 5). Apart from Group 1, other groups were given intraperitone-ally 50 mg/kg of streptozotocin to induce diabetes mellitus. After 72 hours, fasting hyperglycaemia was confirmed by glucose oxidase method. All the rats were fed normal rat chow for 8 weeks. At 8th week, serum and urine samples were analysed for biochemical analysis. After 8 weeks, Group 1 and Group 2 continued to be fed on normal rat chow while other groups were treated with diets (VCO) or drug (metformin) for 4 weeks. At 12th week, urine samples were collected for biochemical analysis, the rats were sacrificed, and blood samples were collected by cardiac puncture.
Results: There were significant differences in some KFPs in diabetes control (Group 2) compared to other experimental groups. However, there was no significant difference in glomerular filtration rate (GFR) and serum sodium in all the groups.
Conclusion: VCO supplementary diet improved the altered KFPs and could be a therapy for kidney problems.
Progress and current status of influenza researches in China
Authors: Shi Tianyun , Feng Xintong , Jie Zhijun 
Published: July 2019

Abstract
Influenza pandemics with different extent occur every year in the world. It can cause high morbidity and mortality, arouse fear panic in public, and attract extensive attention worldwide. This paper reviews the research progress in epidemiological characteristics, detection methods, pathogenesis, treatment and prophylactic measures of influenza in China. It will be helpful for us to understand the current situation of influenza.
Intracoronary cavitation as a cause of plaque rupture and thrombosis propagation in patients with acute myocardial infarction: A computational study
Authors: Rigatelli Gianluca , Zuin Marco , Ngo Tra T. , Nguyen Hung T. , Nanjundappa Aravinda , Talarico Ernest , Duy Le Cao Phuong , Nguyen Thach 
Published: July 2019

Abstract

Background and Objectives
Significant rather than moderate coronary artery stenosis has been postulated to be the main substrate of plaque rupture in acute myocardial infarction (AMI). We evaluate if cavitation could influence the coronary artery plaque rupture contributing to the progression of thrombotic process.

Methods
We reconstructed a 3D model of the left anterior descending coronary artery (LAD) after reviewing the intravascular ultrasound (IVUS) data of 30 consecutive patients with mild to severe coronary artery disease.

Results
Turbulent flow or cavitation occurs in both concentric and eccentric coronary artery stenosis (≥ 75% for the former and ≥ 50% for the latter). The analysis of vapor phase demonstrated that cavitation propagated downstream, creating microbubbles, which exploded when the fluid pressure was lower than the vapor pressure at a local thermodynamic state. The relative higher vorticity magnitude (as turbulent flow in vivo angiogram) observed on the distal cap of the atherosclerotic plaque created a higher turbulence, probably able to destabilize the plaque through a micro-erosion process.

Conclusions
Cavitation seems to be able to promote the thrombotic occlusion within the coronary vessels due the ‘constant injuries’ created by the micro-explosion of bubbles.
Design of a Three-Phase Bidirectional PWM Rectifier with Simple Control Algorithm
Authors: Frisfelds K. , Krievs O. 
Published: July 2019

Abstract
The paper covers the main aspects of designing a low voltage three-phase PWM rectifier for bidirectional AC/DC power flow with unity power factor. A model in Matlab/Simulink environment has been built for a 10kW active rectifier with an LCL filter connected to grid side of the rectifier. The primary goal of the model is to achieve low grid current harmonic content for frequency ranges described in worldwide applicable standards and above. LCL filter parameter design procedure is described in the paper and implemented in the rectifier model to achieve a better power quality with limitations in passive element size. A simple “p-q” theory-based voltage oriented control algorithm is used in the model and described in the present paper. Model performance is characterised by dynamic response, stability and grid parameters during simulation. The simulation results demonstrate that the modelled rectifier system is stable and the grid current harmonic content is low both in the low-and high-frequency ranges.
Utilisation of the Safety Index (Elmeri Index) as the OSH Indicator at Coal Mines
Authors: Rudakov Marat L. , Gridina Elena B. , Ershov Vyacheslav S. 
Published: July 2019

Abstract
The article describes the main performances of the global coal industry, as well as key occupational safety and health indicators (OSH indicators) of the coal mining industry of the Russian Federation. The main goal of the article is to present the results of research of potential utilisation of the Elmeri observation method in order to evaluate safety levels at underground coal mines. The investigation performed taking into consideration two root causes of the occupational traumatism (methane and/or dust explosions, as well as rock falls) has demonstrated good correlation between the calculated values of the safety index and results of the risk assessments at the same underground coal mine under consideration. In addition, the article includes a brief discussion of advantages and restrictions in respect of utilisation of the safety index as the OSH monitoring tool at coal mines.
Impact Modelling of Explosion of Mixture Explosive Charges on the Environment
Authors: Remez N. , Dychko A. , Besarabets Y. , Kraychuk S. , Ostapchuk N. , Yevtieieva L. 
Published: July 2019

Abstract
The present paper provides the modelling of the explosion of the charges of the traditional (trotyl) and new blended explosive substances: polymix GR1/8 (74 %) + KRUK2 (26 %), compolite GS6, polymix GR4-T10. As a result of the research, it has been established that when using TNT a specific impulse is formed, which is by 40 % more than an explosion of new mixed explosives, and the safe distance from the source of the explosion of such explosives is increased by 25 %–50 %. On the basis of the established dependences of excess pressure, the specific impulse on the type and mass of charge, as well as the distance from the epicenter of the explosion, an engineering method has been developed for calculating dangerous parameters of the explosion impact on the environment.
Low-Cost L-Band Receiving System Front-End for Irbene RT-32 Cassegrain Radio Telescope
Authors: Bleiders M. , Berzins A. , Jekabsons N. , Skirmante K. , Bezrukovs Vl. 
Published: July 2019

Abstract
Irbene RT-32 radio telescope is one of the main instruments operated by Ventspils International Radio Astronomy Center (VIRAC), which is used for participation in VLBI and single-dish mode observations, including European VLBI Network (EVN) and other astronomy projects such as recently started research on small bodies of solar system, which involves weak spectral line detection at L-band. Since start of the operation as a radio telescope, single C-X band receiver has been available at RT-32, but regular demand for L-band frequencies has been received due to its importance in spectral line science. In case of RT-32 geometry, optimum dimensions of L-band feed antenna system are inconveniently large and its installation without significant feed cone rebuilding is complicated. While work is currently ongoing to redesign the feed cone for multiple receiver support and to develop high performance L-band feed system, temporal, compact and low-cost receiver has been built and installed laterally to secondary focus, which in sense of performance and functionality has been proven to be appropriate for most of the current needs. Receiver is based on small parabolic reflector allowing one to use a compact dual circular polarized horn antenna, which together with a Cassegrain antenna forms a three-mirror system. Front-end is uncooled that allows reducing operational and maintenance costs, while still providing acceptable noise performance. Practical tests show average overall sensitivity of 750 Jy at 1650 MHz in terms of system effective flux density (SEFD). The paper describes the development of the receiver and presents the main results of performance characterization obtained at Irbene RT-32.
Evaluation Principles of the Dust Influence of Mining Enterprises on the Environment
Authors: Gendler Semen G. , Rudakov Marat L. , Kuznetsov Vladimir S. 
Published: July 2019

Abstract
It has been noted that the areas disturbed by open-pit mining together with the production processes in the extraction of mineral resources (drilling, blasting, transportation, etc.) have a negative influence on the environment in general and the atmosphere in particular. It has been indicated that, in percentage terms, dusting of refuse dumps and tailing dumps plays a prevailing role in the total amount of dust generated. It has been stated that the processes of formation and subsequent transfer of dust in the atmosphere depend on the combination of meteorological and mining factors that have a probabilistic nature in time and space. It has been shown that the maximum value of environmental risk characterises the level of dust influence, at which reduction environmental protection measures should be directed. The present paper proposes a procedure for evaluation of the dusty influence of mining enterprises on the environment. Under the conditions of Olenegorsk GOK, a GIS has been compiled – a project of the study area and, based on geo-information modelling, the results of calculating dust concentrations in the air have been imposed on a digital map of the area.
Sustainable Development of Information Systems for Logistics as a Tool to Strengthen the Competitive Ability on Global Markets
Authors: Štor Matjaž 
Published: July 2019

Abstract
The main purpose of the article is to motivate experts and researchers in the field of business informatics and logistics to interdisciplinary integration in order to develop a new concept of an information system that will help to strengthen a company's competitive ability. The article analyzes the research carried out between top managers, strategic managers and managers of logistics in the largest Slovenian companies. Two hundred companies were included in the primary survey; 60 managers were selected in a representative sample and at the end 30 leaders in statistical analysis. We sent questionnaires to our managers via e-mail. The data were processed with the statistical program IBM SPSS Statistics 19, as a method we used linear regression and multiple correlation. With the primary survey, we measured satisfaction of the managers with existing information support for logistics and found that logistical, strategic information professionals need to be even more connected, so that management decisions can then be developed and sustained. On the basis of the obtained data, it can be concluded that sufficient investment of funds in the creation of an appropriate information system fosters the development of business logistics. The originality and value of the article are reflected in the interdisciplinary view of the concept of information support of logistics in the development of new products, in the original connections of various business functions, in the possibility of designing new information solutions and in the sustainable development of new services for the market.