bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging Obtained Up To 12 Months Preoperatively Is Adequate for Planning Fenestrated/Branched Endovascular Aortic Aneurysm Repair
Authors: Nguyen Tammy T. , Simons Jessica P. , Podder Sourav , Crawford Allison S. , Judelson Dejah R. , Arous Edward J. , Aiello Francesco A. , Schanzer Andres 
Published: July 2019

Objectives: Patients referred for fenestrated/branched endovascular aortic repair (F/BEVAR) often present with a previous computed tomography angiogram (CTA), but it is unknown how recent the CTA must be to ensure accurate F/BEVAR planning. We sought to determine whether anatomic planning parameters change significantly between a CTA used for F/BEVAR planning and a CTA obtained 6 to 12 months prior. Methods: Two blinded observers reviewed preoperative CTAs from 21 patients who underwent F/BEVAR. Each patient had a “recent” scan obtained 0 to 6 months before F/BEVAR planning and a “prior” scan obtained 6 to 12 months before the “recent” CTA. Standard measurements included (1) target vessel separation distances, (2) target vessel origin clock position, and (3) proximal F/BEVAR device diameter. Clinically significant differences for target vessel separation distance, target vessel origin clock position, and proximal F/BEVAR device diameter were predefined as >5 mm, >30 minutes, and >4 mm, respectively. Differences between “recent”/“prior” CTA scans were examined by paired t test. Results: Mean time interval between paired “recent”/“prior” CTAs was 8.0 months (standard deviation: ±1.7). Mean difference in paired “recent”/“prior” target vessel distance (relative to celiac artery [CA]) was 2.6 mm for the superior mesenteric artery (SMA), 2.5 mm for the right renal artery (RRA), and 3.3 mm for the left renal artery (LRA). Of the 21 paired “recent”/“prior” CTAs, clinically significant differences were observed in 2, 4, and 2 patients for SMA, RRA, and LRA target vessel distance, respectively. Target vessel clock position (SMA reference at 12:00) varied by 12 minutes for the CA, 13 minutes for the RRA, and 15 minutes for the LRA. One paired “recent”/“prior” CTA was found to have a clinically significant difference for the LRA. No clinically significant differences were observed for proximal device diameter. Conclusions: In patients who underwent successful F/BEVAR, measurement comparisons between CTAs obtained up to 1 year prior were minor and unlikely to yield clinically significant changes to F/BEVAR design.
Geographic disparities persist despite decline in mortality from IHD in California’s Central Valley 1999–2014
Authors: Spada Ralph , Spada Nicholas , Seon-Spada Hyosim 
Published: July 2019

Background Nationally, ischemic heart disease mortality has declined significantly due to advancements in managing traditional risk factors of hypertension, diabetes, hyperlipidemia, smoking, and obesity and acute intervention. However geographic disparities persist that may, in part, be attributed to environmental effects. Methods Ischemic heart disease age-adjusted mortality were obtained from the CDC database for years 1999 through 2014 by county, gender, race, and Hispanic origin for the Central Valley of California. Results There was an increase in mortality from north to south of 14.9 (95% CI: 8.0–21.9, p value <0.0001) in time period 1, 7.9 (95% CI: 0.8–15, p value <0.05) in time period 2, and 9.2 (95% CI: 4.0–14.3, p value <0.001) in time period 3. In time period 1, the ambient particulate matter ≤2.5 micrometers (PM2.5) level increased from north to south by 0.84 µg/m³ (95% CI: 0.71–0.96), in time period 2 there was a 0.87 µg/m³ increase (95% CI: 0.74–1.0), and a 1.0 µg/m³ increase in time period 3 (95% CI: 0.87–1.1). PM2.5 level was correlated to IHD mortality in all time periods (Period 1 r2 = 0.46, p = 0.0001; Period 2, r2 = 0.34, p = 0.008; Period 3 r2 = 0.51, p value <0.0001). Conclusion Continued declines in ischemic heart disease mortality will depend on the concerted efforts of clinicians in continuing management of the traditional risk factors with appropriate medication use, acute interventions for coronary syndromes, the necessity of patient self-management of high risk behaviors associated with smoking and obesity, and the development of coordinated actions with policy makers to reduce environmental exposure in their respective communities.
Endoscopic papillectomy for neoplastic ampullary lesions: A systematic review with pooled analysis
Authors: Spadaccini Marco , Fugazza Alessandro , Frazzoni Leonardo , Di Leo Milena , Auriemma Francesco , Carrara Silvia , Maselli Roberta , Galtieri Piera Alessia , Chandrasekar Viveksandeep Thoguluva , Fuccio Lorenzo , Aljahdli Emad , Hassan Cesare , Sharma Prateek , Anderloni Andrea , Repici Alessandro 
Published: July 2019

Endoscopic papillectomy (EP) is a viable therapy in ampullary lesions (AL). Many series have reported low morbidity and acceptable outcomes. We performed a systematic review with pooled analysis to assess the safety and efficacy of EP for AL. Electronic databases (Medline, Scopus and EMBASE) were searched up to September 2018. Studies that included patients with endoscopically resected AL were eligible. The rate of adverse events (AEs; primary outcome) and the rates of both technical and clinical efficacy outcomes were pooled by means of a random‐ or fixed‐effects model to obtain a proportion with a 95% confidence interval (CI). Twenty‐nine studies were included (1751 patients). The overall AE rate was 24.9%. The post‐procedural pancreatitis rate was 11.9%, with the only factor affecting this outcome being prophylactic pancreatic stenting. The complete resection rate was 94.2%, with a rate of oncologically curative resection of 87.1%. The recurrence rate was 11.8% (follow‐up: 9.6–84.5 months). EP is a relatively safe and effective option for AL. Our study might definitively suggest the protective role of prophylactic pancreatic stenting against post‐procedural pancreatitis.
A Comparison Between a Meta-analytic Approach and Power Prior Approach to Using Historical Control Information in Clinical Trials With Binary Endpoints
Authors: Isogawa Naoki , Takeda Kentaro , Maruo Kazushi , Daimon Takashi 
Published: July 2019

Background: In the process of research and development of a new treatment, clinical trials are conducted to evaluate its safety and efficacy. Key to streamlining the process is to utilize appropriate historical information on an outcome of a control treatment when designing and analyzing a clinical trial. Methods: For the use of such historical control information, there exist a meta-analytic approach and power prior approach. In this article, we evaluate their performance with regard to the type I error (TIE) rate and power through a simulation study where we analyze the data on a binary outcome of an experimental treatment and a control treatment from a new small-scale trial, along with the corresponding data of the control treatment from multiple historical trials. The reason is that the difference in the performance between the 2 approaches has not been clear. Results: When historical trials were homogeneous, the power was higher in the power prior approach and the meta-analytic approach using a beta-binomial model with a less noninformative prior than the other approaches. However, when heterogeneous historical trials were mixed, the power was lower, or the TIE rates got inflated. Conclusions: To make use of historical control data, if importance is attached to control of the TIE rate, the meta-analytic approach using a normal-normal hierarchical model may be preferable to the power prior approach, whereas if attached to improvement of the power, this preference be reversed. Anyway, the best approach should be chosen by comparing the operational characteristics of the approaches.
Prospective isolation of nonhematopoietic cells of the niche and their differential molecular interactions with HSCs
Authors: Mende Nicole , Jolly Adrien , Percin Gulce I. , Günther Marko , Rostovskaya Maria , Krishnan Shyam M. , Oostendorp Robert A. J. , Dahl Andreas , Anastassiadis Konstantinos , Höfer Thomas , Waskow Claudia 
Published: July 2019

Abstract
The bone marrow niche environment is essential for the control and maintenance of hematopoietic stem cells (HSCs). The investigators present the first global analysis of the communication between distinct niche cell types and HSCs.
Genomic landscape of neutrophilic leukemias of ambiguous diagnosis
Authors: Zhang Haijiao , Wilmot Beth , Bottomly Daniel , Dao Kim-Hien T. , Stevens Emily , Eide Christopher A. , Khanna Vishesh , Rofelty Angela , Savage Samantha , Reister Schultz Anna , Long Nicola , White Libbey , Carlos Amy , Henson Rachel , Lin Chenwei , Searles Robert , Collins Robert H. , DeAngelo Daniel J. , Deininger Michael W. , Dunn Tamara , Hein Than , Luskin Marlise R. , Medeiros Bruno C. , Oh Stephen T. , Pollyea Daniel A. , Steensma David P. , Stone Richard M. , Druker Brian J. , McWeeney Shannon K. , Maxson Julia E. , Gotlib Jason R. , Tyner Jeffrey W. 
Published: July 2019

Abstract
Chronic neutrophilic leukemia (CNL), atypical chronic myeloid leukemia (aCML), and myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN-U) are a group of rare and heterogeneous myeloid disorders. There is strong morphologic resemblance among these distinct diagnostic entities as well as a lack of specific molecular markers and limited understanding of disease pathogenesis, which has made diagnosis challenging in certain cases. The treatment has remained empirical, resulting in dismal outcomes. We, therefore, performed whole-exome and RNA sequencing of these rare hematologic malignancies and present the most complete survey of the genomic landscape of these diseases to date. We observed a diversity of combinatorial mutational patterns that generally do not cluster within any one diagnosis. Gene expression analysis reveals enrichment, but not cosegregation, of clinical and genetic disease features with transcriptional clusters. In conclusion, these groups of diseases represent a continuum of related diseases rather than discrete diagnostic entities.
High frequency of inactivating tetraspanin CD37 mutations in diffuse large B-cell lymphoma at immune-privileged sites
Authors: Elfrink Suraya , de Winde Charlotte M. , van den Brand Michiel , Berendsen Madeleine , Roemer Margaretha G. M. , Arnold Frank , Janssen Luuk , van der Schaaf Alie , Jansen Erik , Groenen Patricia J. T. A. , Eijkelenboom Astrid , Stevens Wendy , Hess Corine J. , van Krieken J. Han , Vermaat Joost S. P. , Cleven Arjen H. G. , de Groen Ruben A. L. , Neviani Viviana , de Jong Daphne , van Deventer Sjoerd , Scheijen Blanca , van Spriel Annemiek B. 
Published: July 2019

Key Points
Loss-of-function mutations in CD37 occur predominantly in diffuse large B-cell lymphoma at immune-privileged sites. CD37-mutated lymphoma B cells show impaired CD37 cell-surface localization, which may have implications for anti-CD37 therapies.
Deep learning for denoising
Authors: Yu Siwei , Ma Jianwei , Wang Wenlong 
Published: July 2019

Compared with traditional seismic noise attenuation algorithms that depend on signal models and their corresponding prior assumptions, removing noise with a deep neural network is trained based on a large training set in which the inputs are the raw data sets and the corresponding outputs are the desired clean data. After the completion of training, the deep-learning (DL) method achieves adaptive denoising with no requirements of (1) accurate modelings of the signal and noise or (2) optimal parameters tuning. We call this intelligent denoising. We have used a convolutional neural network (CNN) as the basic tool for DL. In random and linear noise attenuation, the training set is generated with artificially added noise. In the multiple attenuation step, the training set is generated with the acoustic wave equation. The stochastic gradient descent is used to solve the optimal parameters for the CNN. The runtime of DL on a graphics processing unit for denoising has the same order as the [Formula: see text]-[Formula: see text] deconvolution method. Synthetic and field results indicate the potential applications of DL in automatic attenuation of random noise (with unknown variance), linear noise, and multiples.
Ayotzinapa
Authors: Martínez Ruiz Rosaura 
Published: July 2019

AbstractThis article offers an analysis of some of the reasons why the unveiling of the truth in the Ayotzinapa case, in which forty-three students enrolled in a rural teaching school in Mexico were forcibly taken and then disappeared, must not be postponed. To make a strong case for mourning as a political right, the article first analyzes Hannah Arendt's argument according to which only forgiveness can change a violent course of action, but in order for forgiveness to be offered, the crime to be pardoned must be precisely named. The article then shows how Judith Butler's politics of mourning crosses paths with Arendt's valorization of truth in politics, because both argue for the centrality of reality testing in mourning. In order to add to Butler's account of collective mourning, the article concludes by returning to Freud's psychoanalytic account of the work of mourning, where factual truth proves indispensable to the construction of any history.
Percutaneous fixation with Kirschner wires versus volar locking-plate fixation in adults with dorsally displaced fracture of distal radius: five-year follow-up of a randomized controlled trial
Authors: Costa M. L. , Achten J. , Rangan A. , Lamb S. E. , Parsons N. R. 
Published: July 2019

Aims The aim of this study was to compare the clinical effectiveness of Kirschner wire (K-wire) fixation with locking-plate fixation for patients with a dorsally displaced fracture of the distal radius in the five years after injury. Patients and Methods We report the five-year follow-up of a multicentre, two-arm, parallel-group randomized controlled trial. A total of 461 adults with a dorsally displaced fracture of the distal radius within 3 cm of the radiocarpal joint that required surgical fixation were recruited from 18 trauma centres in the United Kingdom. Patients were excluded if the surface of the wrist joint was so badly displaced it required open reduction. In all, 448 patients were randomized to receive either K-wire fixation or locking-plate fixation. In the K-wire group, there were 179 female and 38 male patients with a mean age of 59.1 years (19 to 89). In the locking-plate group, there were 194 female and 37 male patients with a mean age of 58.3 years (20 to 89). The primary outcome measure was the patient-rated wrist evaluation (PRWE). Secondary outcomes were health-related quality of life using the EuroQol five-dimension three-level (EQ-5D-3L) assessment, and further surgery related to the index fracture. Results At 12 months, 402/448 participants (90%) recruited into the main study provided PRWE scores. At year two, 294 participants (66%) provided scores; at year five, 198 participants (44%) provided scores. There was no clinically relevant difference in the PRWE at any point during the five-year follow-up; at five years, the PRWE score was 8.3 (12.5) in the wire group and 11.3 (15.6) in the plate group (95% confidence interval -6.99 to 0.99; p = 0.139). Nor was there a clinically relevant difference in health-related quality of life. Only three participants had further surgery in the five years after their injury (one in the wire group and two in the plate group). Conclusion This follow-up study continues to show no evidence of a difference in wrist pain, wrist function, or quality of life for patients treated with wires versus locking plates in the five years following a dorsally displaced fracture of the distal radius. Cite this article: Bone Joint J 2019;101-B:978–983.
Developing a standardized approach to virtual clinic follow-up of hip and knee arthroplasty
Authors: Preston N. , McHugh G. A. , Hensor E. M. A. , Grainger A. J. , O’Connor P. J. , Conaghan P. G. , Stone M. H. , Kingsbury S. R. 
Published: July 2019

Aims This study aimed to develop a virtual clinic for the purpose of reducing face-to-face orthopaedic consultations. Patients and Methods Anonymized experts (hip and knee arthroplasty patients, surgeons, physiotherapists, radiologists, and arthroplasty practitioners) gave feedback via a Delphi Consensus Technique. This consisted of an iterative sequence of online surveys, during which virtual documents, made up of a patient-reported questionnaire, standardized radiology report, and decision-guiding algorithm, were modified until consensus was achieved. We tested the patient-reported questionnaire on seven patients in orthopaedic clinics using a ‘think-aloud’ process to capture difficulties with its completion. Results A patient-reported 13-item questionnaire was developed covering pain, mobility, and activity. The radiology report included up to ten items (e.g. progressive periprosthetic bone loss) depending on the type of arthroplasty. The algorithm concludes in one of three outcomes: review at surgeon’s discretion (three to 12 months); see at next available clinic; or long-term follow-up/discharge. Conclusion The virtual clinic approach with attendant documents achieved consensus by orthopaedic experts, radiologists, and patients. The robust development and testing of this standardized virtual clinic provided a sound platform for organizations in the United Kingdom to adopt a virtual clinic approach for follow-up of hip and knee arthroplasty patients. Cite this article: Bone Joint J 2019;101-B:951–959.
Pengaruh Usia Menarche terhadap Tinggi Badan Wanita di Daerah Endemis Gondok
Authors: Hidayat Muhammad Taufiq , Handayani Selfi , Munawaroh Siti 
Published: July 2019

<p class="AbstractNormal"><strong><em><span lang="EN-ID">Introduction</span>: </em></strong><em>Height affected by various factor. One factor that can affect female’s height is menarcheal age. Sexual hormone in female’s body will be activated at menarche and it will stimulate the closure of epiphyseal plate. Final height in female with late menarche is higher than female with early menarche. While in goiter endemic areas with Iodine Deficiency Disorder especially in mountain area, it has earlier menarcheal age than normal female that live in non goiter endemic area. This study aimed to analyze the relationship between age at menarche and height endemic goiter.</em></p><p class="AbstractNormal"><strong><em>Method</em></strong><em>s: This study was an observational study with cross-sectional design. It was held in the goiter endemic Ngargoyoso, Karanganyar. Samples of women aged over 20 years with upright posture that live in Ngargoyoso were obtained by simple random sampling, then measuring the height using statometer and obtaining menarcheal age by questioner. Data were analyzed using Pearson correlation test (α = 0.05), which had previously been tested for normality by Kolmogorov Smirnov.</em></p><p class="AbstractNormal"><strong><em>Results: </em></strong><em>The mean age of menarche sample was 13.38 years with the lowest age of 11 years and the highest age of 18 years. While the average height was 156.8 cm samples with the lowest height was 139 cm and the highest was 168 cm. Pearson correlation test results showed that height was significantly associated with age at menarche woman endemic goiter (p = 0.001).</em></p><p class="AbstractNormal"><strong><em>Conclusions: </em></strong><em>Age of menarche associated with height in an endemic goiter area.<br />The earlier age of menarche will affect the final height of the woman.</em></p><p class="Keywords"> </p>
PERANAN PENDIDIKAN AGAMA ISLAM DALAM PENGUATAN NASIONALISME DI INDONESIA
Authors: Hamid Abdul 
Published: July 2019

Abstract
The 21st century is a triumph for the era of globalization. An era that tries to make the world, especially the world incorporated in the third world category (developed) like Indonesia to carefully and firmly address all the effects it produces. Globalization is, in essence, a process of generating ideas, then offered to be followed by other nations that eventually arrive at a common point of agreement and serve as a common ground for nations around the world. Globalization as well as nationalism is a concept of a pluralistic. Substantively also contains a contradictory spirit. Nationalism with the spirit of exclusiveness desires loyalty to the nation and state. Nationalism, in any way, tried to convince a nation that felt the same ground, breathed the same air, and drank water from the same source, that is, Bumi Indonesia. To love the homeland that gives the source of life as a gift of Allah SWT. So that every form of natural produce should be utilized as well as possible for the common welfare as a nation. In the process, Indonesia tries to shed tribal, religious, racial and linguistic identity for a cooperation to achieve prosperity. While Islam is one of the religions that desires the unity and unity among human beings. Encourage his people to love and work for the inhabited country.
Abstrak
Abad 21 merupakan masa kejayaan bagi era globalisasi. Sebuah era yang mencoba menjadikan dunia, khususnya dunia yang tergabung dalam kategori dunia ketiga (berkembang) seperti Indonesia untuk secara cermat dan tegas menyikapi segala efek yang ditimbulkannya. Globalisasi pada hakikatnya adalah suatu proses dari gagasan yang dimunculkan, kemudian ditawarkan untuk diikuti oleh bangsa lain yang akhirnya sampai pada suatu titik kesepakatan bersama dan menjadi pedoman bersama bagi bangsa-bangsa di seluruh dunia. Globalisasi sebagaimana juga nasionalisme adalah sebuah konsep berwajah majemuk. Secara substansif juga mengandung semangat yang bertolak belakang. Nasionalisme dengan semangat eksklusifisme menghendaki kesetiaan kepada bangsa dan negara. Nasionalisme, dalam rupa apapun sejatinya mencoba meyakinkan bangsa yang merasa berpijak pada bumi yang sama, menghirup udara yang sama, juga meneguk air dari sumber yang sama, yakni Bumi Indonesia. Untuk mencintai tanah airnya yang memberikan sumber kehidupan sebagai anugerah Allah SWT. Sehingga setiap wujud hasil alam harus dimanfaatkan dengan sebaik-baiknya untuk kesejahteraan bersama sebagai suatu bangsa. Dalam prosesnya, Indonesia mencoba menanggalkan identitas kesukuan, agama, ras maupun bahasa demi sebuah kerjasama mencapai kesejahteraan. Sementara Islam adalah salah satu agama yang sangat menghendaki adanya persatuan dan kesatuan antar umat manusia. Menganjurkan umatnya untuk mencintai dan bekerja untuk negeri yang didiami.
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