bluuebunny/crossref_metadata_2025_split huggingface dataset:
INTRAPERITONEAL USING OF BUPIVАCAIN FOR THE ANESTHESIA OF PATIENTS AFTER LAPAROSCOPIC CHOLECYSTECTOMY
Authors: Glumcher F.S. , Solyaryk S.O. , Oliynyk O.V. , Kolosovych A.I. 
Published: July 2019

Relevance. The local anesthetics were used intraperitoneally after some minimally invasive gynecological interventions like a component of postoperative multimodal anesthesia in recent years. Objective. The aim of work was to study the effectiveness of intraperitoneal administration of bupivokain for the anesthesia of patients after laparoscopic cholecystectomy. Material and methods. 28 patients aged 32-60 years (16 women, 12 men) were examined. The patients were divided into two groups. In the first group for anesthesia after the operation, was used ketorolac trometamine in dose 0.2 mg/kg intramuscularly each 6 hours. If the patient complained of postoperative pain, which was assessed by Visual-analog scale in 7 points or higher, fentanyl was administered intramuscularly in dose of 0.003 μg/kg. In the second group, besides the components of multimodal anesthesia used in the first group, at the end of the surgical intervention at the drainage tubes were injected 40 ml of 0.125% solution of bupivocaine (50 mg). This injection was repeated throughout the first day each 6 hours. The condition of patients was assessed by a Visual-analog scale after 1, 4, 8, 12 and 24 hours after the finishing of surgery. The average dose of fentanyl in μg/kg used for postoperative anesthesia first 24 hours after operation was also determined. Results. We have received a significant reduction in the rates of pain evaluation for Visual-analog scale in patients who used bupivacaine as a component of multimodal anesthesia. One hour after the end of the operation, the pain score for Visual-analog scale was less than the corresponding one in the control group in 1.77 times, after 4 hours – in 1.47, and in 8 hours – in 1.55 times. In all cases, P <0.001. The mean dose of fentanyl used for treatment in the study group was 1.55 times less than that in the control group. There were no significant complications in both groups. A patient in group 1 had nausea, requiring a single dose of ondasetron 2 mg Conclusion. Intraperitoneal administration of bupivocaine had a significant anesthetic effect after laparoscopic cholecystectomy.
Menanamkan Nilai-Nilai Kewirausahaan pada Anak Usia Dini
Authors: Marini Marini 
Published: July 2019

The purpose of this research is to describe how to embed entrepreneurial values in early childhood in Kudus. This research was conducted by research method of survey on 36 early childhood educational institution in Kudus in academic year 2017/2018. Data collection techniques are conducted with questionnaire techniques, observations, and interviews. Entrepreneurship education in early childhood educational institution in Kudus aims to foster an entrepreneurial interest and instill social values, economic value, creativity, forming a patient person, appreciating hard-earned, appreciating their own work, disciplined, independent, and responsible. The activity of the planting of entrepreneurial values in early childhood in Kudus is carried out with diverse strategies, ranging from observation to the entrepreneurial places, playing the role of buying and selling, direct buying and selling practices, making something that can be for sale, livestock and farming. Such activities require adequate time, place, and energy. Thus it needs to be planned maturely, so that the implementation of learning runs effectively.
POTENSI LARUTAN CHITOSAN 0,2% SEBAGAI ALTERNATIF BAHAN IRIGASI DALAM PERAWATAN SALURAN AKAR GIGI
Authors: Deviyanti Sinta 
Published: July 2019

Irigasi dan instrumentasi merupakan salah satu faktor yang berperan penting dalam perawatan saluran akar gigi. Penggunaan instrumen manual dan instrumen yang digerakkan mesin, akan menghasilkan smear layer yang menutupi dinding saluran akar dan tubuli dentin yang terbuka.Pembersihkan debridement secara menyeluruh serta pembersihan smear layer merupakan landasan untuk mencapai keberhasilan perawatan saluran akar gigi. Irigasi dengan sodium hipoklorit (NaOCl) yang dikombinasi dengan bahan khelasi seperti Ethylenediaminetetraacetic (EDTA) telah direkomendasikan untuk pembersihan komponen organik dan komponen inorganik dari smear layer secara efektif. Namun, EDTA dapat bersifat erosif terhadap dentin, konsekuensinya mempengaruhi sifat kekerasan, permeabilitas dan pelarutan dentin di bagian dalam akar gigi. Penggunaan NaOCl tidak mampu membersihkan smear layer, karena hanya efektif terhadap debris organik. Oleh karena itu,dibutuhkan penelitian untuk mencari larutan irigasi yang lebih kompatibel, efesien membersihkan smear layer dan menyebabkan erosi dentin yang lebih rendah. Saat ini, chitosan telah diteliti di bidang kedokteran gigi.Chitosan adalah polisakarida alamiah, berasal dari deasetilasi chitin yang terdapat pada cangkang kepiting dan udang. Chitosan memiliki kemampuan khelasi, biokompatibel, biodegradasi, bioadhesi dan tidak toksik terhadap tubuh manusia. Hasil-hasil penelitian terbaru telah menyimpulkan bahwa irigasi akhir dengan larutan Chitosan 0,2% setelah irigasi dengan larutan NaOCl, lebih efesien dalam membersihkan smear layer dibanding bahan irigasi lainnya dan menyebabkan erosi lebih sedikit pada dentin akar gigi. Chitosan dapat dipertimbangkan sebagai alternatif bahan irigasi dalam perawatan saluran akar gigi karena memiliki kemampuan khelasi pada dentin saluran akar gigi.
MONTELUKAST: NEWER MODALITY IN VERNAL KERATOCONJUNCTIVITIS (VKC)
Authors: Shukla Dr. Prachi , Gupta Dr Rajiv 
Published: July 2019

Vernal Keratoconjunctivitis (VKC) is a chronic, bilateral allergic inflammation of the conjunctiva. The disease is seasonal, recurrent & commonly seen among young boys.
Common symptoms of the disease are redness, itching, lacrimation, photophobia, foreign body sensation & a characteristic ropy discharge. Signs found in VKC are conjunctival congestion, giant papillae involving upper palpebral conjunctiva & the limbus, Tranta’s dots & superficial keratitis. (1,2). Patients with VKC frequently have a positive family history or history of allergic diseases like asthma, rhinitis, atopic dermatitis etc.(3).
Anaesthetic Management of a Parturient with Dilated Cardiomyopathy
Authors: Nandy Alak , Biswas Rajat Sanker Roy , Mabud Farah Naz , Sultana Aklima 
Published: July 2019

Dilated Cardiomyopathy (DCM) is a form of cardiomyopathy characterized by left ventricular or biventricular dilatation and impaired ventricular contractility. This results in systolic dysfunction of the heart with decreased left ventricular ejection fraction and progressive cardiac failure. This case report describes the successful anaesthetic management of a parturient with Dilated cardiomyopathy underwent Caesarian section under spinal anaesthesia.
Chatt Maa Shi Hosp Med Coll J; Vol.18 (1); Jan 2019; Page 52-53
Characterization and Disintegrant Potential of Phosphorylated Tiger Nut (Cyperus esculentus) Starch in Immediate Release Ibuprofen Tablet Formulation
Authors: Onwuatuegwu Onyinye D , Azubuike Chukwuemeka P , Aloko Sinmisola , Ologunagba Modupe O , Igwilo Cecilia I 
Published: July 2019

The study was aimed at evaluating the physicochemical properties of phosphorylated tiger nut starch (TNP) and its disintegrant properties in immediate release ibuprofen tablets. Native tiger nut starch (TNS) was modified by phosphorylation with disodium hydrogen orthophosphate at 130oC and its physicochemical properties were evaluated. Ibuprofen tablets were formulated with TNP and sodium starch glycolate (SSG) at concentrations of 5.0, 7.5, 10.0 and 15.0% as disintegrants. Phosphorylation of TNS led to improved flow properties and swelling and hydration capacities among other changes in the physicochemical properties. TNP had comparable properties with SSG. FTIR study confirmed modification and also showed that TNP is compatible with ibuprofen powder. Ibuprofen tablets produced with TNP as disintegrant had acceptable tablet properties comparable to those produced with SSG. The disintegrant potential improved with increased concentration of TNP. The results indicate that TNP has a promising disintegrant potential in tablet formulations.
Dhaka Univ. J. Pharm. Sci. 18(1): 21-29, 2019 (June)
Music therapy on non linear assessment of cardiac autonomic function in patients with major depressive disorder
Authors: Islam Shams Ruhani , Ferdousi Sultana 
Published: July 2019

Background :Non linear measure of heart rate variability (HRV) is an emerging method to detect changes in cardiac autonomic nerve function in major depressive disorder (MDD).
Objective: To observe the effect of music therapy on non linear measures of HRV in newly diagnosed MDD patients.
Methods: This prospective interventional study was done in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka in 2018 on 60 newly diagnosed MDD patients aged 20-40 years, both male and female. They were further subdivided into 30 patients with only antidepressant medication (Mirtazapine) and 30 patients received music therapy with Raga kafi (Rabindrasangeet) along with the same medication for 3 months. Age, sex and BMI matched healthy control were also enrolled. HRV non linear parameters were recorded by Power Lab 8/35. For statistical analysis paired sample ‘t’ test and independent sample ‘t’ test were done.
Result: SD1, SD2 and SD1/SD2 were found significantly lower in MDD patients compared to healthy control at baseline. After 3 months of music therapy, significant increment of these parameters occurred with trend of improvement in cardiac autonomic nerve function (CANF) in these patients.
Conclusion: This study concluded that music therapy can improve CANF by increasing parasympathetic and reducing sympathetic activity in MDD patients.
J Bangladesh Soc Physiol. 2019, June; 14(1): 7-13
Effect of slow breathing exercise on non linear Heart rate variability in transfusion dependent thalassemic patients
Authors: Das Kamol Chandra , Ferdousi Sultana 
Published: July 2019

Background: Nonlinear measure of heart rate variability (HRV) is an emerging tool to detect changes in cardiac autonomic nerve function (CANF) in transfusion dependent thalassemic (TDT) patients. Slow breathing exercise (SBE) can significantly improve HRV in health and various diseases.
Objective: To observe the effect of slow breathing exercise (SBE) on non linear measures of HRV in TDT patients.
Methods: This prospective interventional study was done in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka in 2018 on 60 male TDT patients aged 15-30 years. Thirty patients received conventional treatment and 30 patients performed slow breathing exercise along with the conventional treatment for 3 months. Age and sex matched 30 healthy control were enrolled. All subjects were followed up at baseline and after 3 months. Non linear (Poincare) HRV parameters were recorded by Power Lab 8/35 AD Instrument, Australia. For statistical analysis paired sample ‘ t’ test and independent sample ‘t’ test were used.
Result: SD1, SD2 and SD1/SD2 were found significantly lower in TDT patients compared to healthy control at baseline. After 3 months of slow breathing exercise, significant increment of these parameters occurred with trend of improvement in cardiac autonomic nerve function in this group of patients.
Conclusion: Slow breathing exercise may improve cardiac autonomic nerve function and sympathovagal balance in transfusion dependent thalassemic patients.
J Bangladesh Soc Physiol. 2019, June; 14(1): 26-32
PENGARUH STATUS SOSIAL EKONOMI TERHADAP KINERJA GURU EKONOMI DI SMA KOTA MALANG
Authors: Sefaverdiana Putri Vina 
Published: July 2019

Peran dan tanggung jawab seorang guru sangat penting dalam mencapai tujuan pendidikan nasional. Guru adalah salah satu penentu tinggi rendahnya mutu pendidikan. Kinerja professional guru sangat berpengaruh terhadap kelangsungan seluruh proses pembelajaran di dalam kelas pada akhirnya akan mempengaruhi kualitas lulusan.Tujuan dari penelitian ini untuk mengetahui apakah terdapat pengaruh status sosial ekonomi terhadap kinerja guru ekonomi di SMA Kota Malang. Penelitian ini menggunakan metode penelitian deskriptif dengan pendekatan kuantitatif yang berfokus pada perbandingan antar variable yaitu variable X dan variable Y. Penelitian ini merupakan penelitian eksplanatori. Subjek penelitian ini adalah guru Ekonomi di SMA Kota Malang yang berjumlah 82 guru di 10 SMA Negeri dan 34 SMA Swasta. Teknik pengumpulan data dengan angket. Teknik pengolahan data menggunakan spss Uji t yaitu untuk mencari korelasi antara variabel X dan Y. Pada penghitungan hipotesis didapatkan nilai Sig 0,031. Hasil tersebut menunjukkan bahwa nilai Sig lebih kecil dari 0,05 (0,031 kurang dari 0,05). Hal ini berarti hipotesis yang diajukan peneliti diterima yaitu terdapat pengaruh yang positif dan signifikan dalam penelitian yang berjudul “Pengaruh Status Sosial Ekonomi Terhadap Kinerja Guru Ekonomi di SMA Kota Malang” dapat teruji kebenarannya. Dengan demikian dapat disimpulkan bahwa status sosial ekonomi sangat berpengaruh dan signifikan terhadap kinerja guru. Dalam artian bahwa penelitian ini mampu menjawab kebenaran hipotesis yang diajukan.
APLIKASI PENJADWALAN PIKET HARI LIBUR BAGI KARYAWAN PT. ASTRA INTERNASIONAL.Tbk (AUT0 2000) PALEMBANG
Authors: Juliandri Acep 
Published: July 2019

From the results of research conducted on the data or information obtained about the needs that are needed, it will become the employee scheduling application program. To do data processing, employee scheduling at PT. Astra Internasional, Tbk ( Auto2000) Palembang which provides sales, maintenance, repair and supply of Toyota spare parts that are still being done using Excel Office Microsoft. How to make a schedule that takes a long time? To overcome these problems, it is necessary to have a new computerized system to improve work efficiency by making PT. Astra Internasional, Tbk ( Auto2000) Palembang Employee Picking Application Schedule. This system produces, Employee Pickup Schedule using PHP and MySQ.
MicroRNA-153 Decreases Tryptophan Catabolism and Inhibits Angiogenesis in Bladder Cancer by Targeting Indoleamine 2,3-Dioxygenase 1
Authors: Zhang Wentao , Mao Shiyu , Shi Donghui , Zhang Junfeng , Zhang Ziwei , Guo Yadong , Wu Yuan , Wang Ruiliang , Wang Longsheng , Huang Yong , Yao Xudong 
Published: July 2019

Background: Metastasis is the primary cause of cancer deaths, warranting further investigation. This study assessed microRNA-153 (miR-153) expression in bladder cancer tissues and investigated the underlying molecular mechanism of miR-153-mediated regulation of bladder cancer cells.Methods: Paired tissue specimens from 45 bladder cancer patients were collected for qRT-PCR. The Cancer Genome Atlas (TCGA) dataset was used to identify associations of miR-153 with bladder cancer prognosis. Bladder cancer tissues and immortalized cell lines were used for the following experiments: miR-153 mimics and indoleamine 2,3-dioxygenase 1 (IDO1) siRNA transfection; Western blot, cell viability, colony formation, and Transwell analyses; nude mouse xenograft; and chicken embryo chorioallantoic membrane angiogenesis (CAM) assays. Human umbilical vein endothelial cells (HUVECs) were co-cultured with bladder cancer cells for the tube formation assay. The luciferase reporter assay was used to confirm miR-153-targeting genes.Results: miR-153 expression was downregulated in bladder cancer tissues and cell lines, and reduced miR-153 expression was associated with advanced tumor stage and poor overall survival of patients. Moreover, miR-153 expression inhibited bladder cancer cell growth by promoting tumor cell apoptosis, migration, invasion, and endothelial mesenchymal transition (EMT) in vitro and tumor xenograft growth in vivo, while miR-153 expression suppressed HUVEC and CAM angiogenesis. At the gene level, miR-153 targeted IDO1 expression and inhibited bladder cancer cell tryptophan metabolism through inhibiting IL6/STAT3/VEGF signaling.Conclusions: Collectively, our data demonstrate that miR-153 exerts anti-tumor activity in bladder cancer by targeting IDO1 expression. Future studies will investigate miR-153 as a novel therapeutic target for bladder cancer patients.
Evaluating possible acute coronary syndrome in primary care: the value of signs, symptoms, and plasma heart-type fatty acid-binding protein (H-FABP). A diagnostic study
Authors: Willemsen Robert TA , Winkens Bjorn , Kietselaer Bas LJH , Smolinska Agnieszka , Buntinx Frank , Glatz Jan FC , Dinant Geert-Jan 
Published: July 2019

BackgroundAdditional diagnostic means could be of added value when evaluating possible acute coronary syndrome (ACS) in primary care.AimTo determine whether heart-type fatty acid-binding protein (H-FABP)-based point-of-care (POC) biomarker testing, embedded in a clinical decision rule (CDR), is helpful to the GP when evaluating possible ACS.Design & settingA prospective, non-randomised, double-blinded, diagnostic derivation study was undertaken, with a delayed-type cross-sectional diagnostic model among GPs in the Netherlands and Belgium.MethodSigns and symptoms predicting acute myocardial infarction (AMI) or ACS were identified using both logistic regression analysis, and classification and regression trees (CART). Diagnostic values of the POC H-FABP test (cut-off value 4 ng/ml) alone and as part of a CDR were determined.ResultsA total of 303 participants (48.8% male) with chest pain or discomfort who had consulted a GP were enrolled. ACS was found in 32 (10.6%) of these 303 patients. For ACS, sensitivity and negative predictive value (NPV) of the POC H-FABP test was 25.8% (95% confidence interval [CI] = 12.5 to 44.9) and 91.6% (95% CI = 87.6% to 94.5%), respectively. The area under the receiver operating curve of the optimal CDR was 0.78 for ACS.ConclusionSensitivity of the current H-FABP POC test (cut-off value 4 ng/ml) as a stand-alone test is poor, either owing to limitations of the marker or of the test device. Usability of a CDR derived from these results is doubtful: the number of ACS cases missed by the GP is reduced but, as a consequence, disproportionally more ACS-negative patients are referred.
KARAKTERISTIK ORANG TUA YANG BERHUBUNGAN DENGAN STATUS GIZI BALITA DI DESA GAJI DEMAK
Authors: Susilowati Endang 
Published: July 2019

Masa balita adalah masa yang paling hebat dalam tumbuh kembang, dimana terdapat periode transisi dari makanan bayi ke makanan orang. Masih ada 38,9% Balita di Indonesia yang masing mengalami masalah gizi, terutama Balita dengan tinggi badan dan berat badan (pendek – normal) sebesar 23,4% yang berpotensi akan mengalami kegemukan, Tujuan peneltian ini adalah mengetahui hubungan karakteristik ibu dengan status gizi balita di Desa Gaji kecamatan Guntur Kabupaten Demak. Penelitian ini menggunakan metode survey analitik dengan pendekatan waktu crosssectional, Sampel dalam penelitian ini adalah semua ibu yang mempunyai Balita usia 0 – 60 bulan sejumlah 80 orang dengan teknik total sampling, instrument yang digunakan adalah kuesioner yang berisi tentang karakteristik dan alat ukur berat badan serta tinggi badan untuk menegetahui status gizi balita.Uji statistic menggunakan chi square.Hasil penelitian terdapat hubungan antara umur ibu dengan status gizi balita (p value = 0,025), tidak terdapat hubungan antara umur ibu dengan status gizi balita (p value = 0,245), terdapat hubungan antara pekerjaan ibu dengan status gizi balita(p value = 0,016), terdapat hubungan antara pendapatan keluarga dengan status gizi balita(p value = 0,000) Kata kunci : umur, pendidikan, pekerjaan, pendapatan, status gizi, balita. CHARACTERISTICS OF PARENTS RELATED TO THE NUTRITION STATUS IN GAJI VILLAGE DEMAK ABSTRACT Childhood is the most intense period of growth and development, where there is a transition period from baby food to people's food. There are still 38.9% of under-five-children in Indonesia who has nutritional problems and 23.4% have potential to become obesity. The purpose of this study was to determine the relationship between the characteristics of mothers with nutritional status under-five-children in Gaji Village, Demak District. This research method used analytical survey method with cross-sectional approach. The sample in this study were all mothers who have children aged 0 - 60 months which is 80 people using the total sampling technique. The instrument was a questionnaire containing the characteristics and measuring instruments of weight and height to determine the nutritional status of children. Statistical tests had been done with chi square. The results of the study showed there is a relationship between maternal age and nutritional status of children (p value = 0.025), there is no correlation between maternal age and nutritional status of children (p value = 0.245), there is a relationship between the work of mothers and nutrition status (p value = 0.016) , there is a relationship between family income and nutritional status (p value = 0,000). keywords: age, education, employment, income, nutritional status, under-five-children
PENGARUH INISIASI MENYUSU DINI TERHADAP KONTRAKSI UTERUS PADA IBU NIFAS DI PUSKESMAS SLAWI KABUPATEN TEGAL
Authors: Setyatama Ike Putri , Anggraeni Ika Esti , Pamuji Siti Erniyati Berkah 
Published: July 2019

Perdarahan merupakan penyebab utama kematian ibu di Kabupaten Tegal pada Tahun 2017. Berdasarkan hasil survei di Puskesmas Slawi tahun 2018, terdapat 30 ibu bersalin yang mengalami perdarahan postpartum. Inisiasi Menyusu Dini (IMD) adalah perilaku pencarian puting payudara ibu sesaat setelah bayi lahir. Melaksanakan IMD akan menstimulasi produksi hormon oksitosin secara alami. Hormon Oksitosin ini membantu uterus berkontraksi, sehingga dapat mengontrol perdarahan nifas.Tujuan penelitian untuk menganalisis pengaruh IMD terhadap kontraksi uterus pada ibu nifas di Puskesmas Slawi. Populasi dalam penelitian ini adalah ibu yang bersalin di Puskesmas Slawi periode bulan Januari-Desember tahun 2018 sebanyak 215 responden, dan sampel sebanyak 140 responden. Desain penelitian ini menggunakan metode survei dengan pendekatan case control. Berdasarkan perhitungan Chi Square dengan α = 0,05 diperoleh nilai p sebesar 0,029. Karena nilai p < α berarti secara statistik hasil pengujian signifikan, berarti ada hubungan antara variabel, dan hasil uji statistik pengaruh dengan Regresi Logistik, diperoleh nilai Sig. 0,029, berarti ada pengaruh antara variabel dengan R Square 0,034, berarti bahwa variabel IMD berpengaruh terhadap kontraksi uterus sebesar 3,4%. Kesimpulan dalam penelitian ini ada hubungan dan ada pengaruh IMD terhadap kontraksi uterus ibu nifas di Puskesmas Slawi Kabupaten Tegal. Kata kunci : inisiasi menyusu dini; kontraksi uterusTHE EFFECT OF EARLY INITIATION OF BREASTFEEDING TOWARDS UTERINE CONTRACTION FOR POSTPARTUM MOTHER AT PUSKESMAS SLAWI TEGAL REGENCY Hemorrhage is the main cause of maternal mortality in Tegal regency 2017. Based on the survey at Slawi District Health Centre, in January – December 2018, there were 30 women in labor with postpartum hemorrhage. Early Initiation of Breastfeeding (IMD) is an act performed by the baby in finding mother’s nipple after born. IMD will stimulate oxytocin hormones helping uterine to get contraction and can control hemorrhage after labor. The study was aimed to analyze the effect of IMD towards uterine contraction for postpartum mother at Slawi District Health Centre. The population was women in labor at Puskesmas Slawi as 215 respondents; the sample was 140 women in labor, and performed or not performed IMD The research design applied case control study..Based on Chi Square with α = 0.05, p value was 0.029. It refused Ho; there was a relationship of those variables. The logistic regression described that Sig. value was 0.029; it showed an effect of those variables with R square of 0.034 stating IMD had an effect of uterine contraction as 3.4%. Therefore, there were a relationship and an effect of IMD towards uterine contraction of postpartum mother at Puskesmas Slawi. Keywords: early initiation of breastfeeding; uterine contraction