bluuebunny/crossref_metadata_2025_split huggingface dataset:
Humanized GPIbα–von Willebrand factor interaction in the mouse
Authors: Kanaji Sachiko , Orje Jennifer N. , Kanaji Taisuke , Kamikubo Yuichi , Morodomi Yosuke , Chen Yunfeng , Zarpellon Alessandro , Eberhardt Jerome , Forli Stefano , Fahs Scot A. , Sood Rashmi , Haberichter Sandra L. , Montgomery Robert R. , Ruggeri Zaverio M. 
Published: October 2018

AbstractThe interaction of platelet glycoprotein Ibα (GPIbα) with von Willebrand factor (VWF) initiates hemostasis after vascular injury and also contributes to pathological thrombosis. GPIbα binding to the VWF A1 domain (VWFA1) is a target for antithrombotic intervention, but attempts to develop pharmacologic inhibitors have been hindered by the lack of animal models because of the species specificity of the interaction. To address this problem, we generated a knockin mouse with Vwf exon 28–encoding domains A1 and A2 replaced by the human homolog (VWFh28). VWFh28 mice (M1HA) were crossbred with a transgenic mouse strain expressing human GPIbα on platelets (mGPIbαnull;hGPIbαTg; H1MA) to generate a new strain (H1HA) with humanized GPIbα-VWFA1 binding. Plasma VWF levels in the latter 3 strains were similar to those of wild-type mice (M1MA). Compared with the strains that had homospecific GPIbα-VWF pairing (M1MA and H1HA), M1HA mice of those with heterospecific pairing had a markedly greater prolongation of tail bleeding time and attenuation of thrombogenesis after injury to the carotid artery than H1MA mice. Measurements of GPIbα-VWFA1 binding affinity by surface plasmon resonance agreed with the extent of observed functional defects. Ristocetin-induced platelet aggregation was similar in H1HA mouse and human platelet-rich plasma, and it was comparably inhibited by monoclonal antibody NMC-4, which is known to block human GPIbα-VWFA1 binding, which also inhibited FeCl3-induced mouse carotid artery thrombosis. Thus, the H1HA mouse strain is a fully humanized model of platelet GPIbα-VWFA1 binding that provides mechanistic and pharmacologic information relevant to human hemostatic and thrombotic disorders.
Comparison of Comorbidity and Frailty Indices in Patients With Head and Neck Cancer Using an Online Tool
Authors: Vitzthum Lucas K. , Feng Christine H. , Noticewala Sonal , Hines Paul J. , Nguyen Cammie , Zakeri Kaveh , Sojourner Elena J. , Shen Hanjie , Mell Loren K. 
Published: October 2018

Purpose Comorbidity is an independent predictor of mortality and treatment tolerance in head and neck cancer and should be considered with regard to treatment intensification. Multiple previously validated models can be used to evaluate comorbidity and propensity to benefit from intensive treatment, but they have not been directly compared. Materials and Methods An online tool was developed and used to calculate the Charlson Comorbidity Index (CCI), Adult Comorbidity Evaluation-27 (ACE-27), Cumulative Illness Rating Scale for Geriatrics (CIRS-G), Geriatric 8 (G8), Cancer and Aging Research Group (CARG), and Generalized Competing Event (GCE) scores. To assess interrater variability, five evaluators independently calculated scores on a retrospective cohort of 20 patients. Correlation between models as well as age and performance status were calculated from a cohort of 40 patients. Results The GCE and G8 models had an excellent (intraclass correlation coefficient and Fleiss’ kappa ≥ 0.75) degree of interrater agreement. The CCI, ACE-27, CIRS-G, and CARG had a good (intraclass correlation coefficient and Fleiss’ kappa 0.6-0.74) degree of interrater agreement. There was statistically significant correlation between models, especially with the CCI, ACE-27, and CIRS-G indices. Increased age was correlated with an increased CCI score and having moderate to severe comorbidity was correlated with the ACE-27 model. Except for the G8 model, the comorbidity indices were not associated with Eastern Cooperative Oncology Group performance status. Conclusion We developed an online tool to calculate indices of comorbidity in patients with head and neck cancer with a high degree of reproducibility. Comorbidity is not strongly correlated with performance status and should be independently evaluated in patients.
Chemotherapy-Free Initial Treatment of Advanced Indolent Lymphoma Has Durable Effect With Low Toxicity: Results From Two Nordic Lymphoma Group Trials With More Than 10 Years of Follow-Up
Authors: Lockmer Sandra , Østenstad Bjørn , Hagberg Hans , Holte Harald , Johansson Ann-Sofie , Wahlin Björn Engelbrekt , Wader Karin Fahl , Steen Chloé Beate , Meyer Peter , Maisenhølder Martin , Smedby Karin Ekström , Brown Peter , Kimby Eva 
Published: October 2018

Purpose For indolent lymphoma, the optimal timing, sequence, and choice of therapeutic regimens remain a matter of debate. In two Nordic Lymphoma Group randomized trials, symptomatic or clearly progressing patients were treated first line with a rituximab-containing regimen without chemotherapy. The purpose of this study was to assess long-term survival, risk of transformation, and need of new therapies. Methods Data were collected at cross-sectional follow-up for 321 patients with indolent lymphoma (84% with follicular lymphomas [FL]) included in one of two Nordic Lymphoma Group trials (accrual 1998 to 1999 and 2002 to 2008). All patients received first-line therapy with one or two cycles of four weekly infusions of rituximab 375 mg/m2, and 148 were randomly allocated to the addition of interferon alfa-2a. Follow-up data were retrieved from initial trial databases and medical records on repeated clinical evaluations. Results At the end of follow-up, 73% of patients were alive, with a median follow-up after random assignment of 10.6 years. Among all, 36% (38% with FL) had never needed chemotherapy. For patients with FL who required new therapy within 24 months because of early disease progression, the 10-year survival rate was 59% versus 81% for those with longer remission. Interferon was not shown to improve long-term outcome. Transformation was diagnosed in 20% of all patients (2.4% per person-year) and in 18% with FL. An additional malignancy was found in 12%. Conclusion Approximately one third of patients with symptomatic indolent lymphoma (30% with FL, 23% without FL) did not need new therapy in the long term after first-line rituximab without chemotherapy. In the entire cohort, 10-year survival was excellent with no major safety issues, which suggests that chemotherapy can be delayed safely in the majority of patients.
Species delimitation at a global scale reveals high species richness with complex biogeography and patterns of symbiont association in Peltigera section Peltigera (lichenized Ascomycota: Lecanoromycetes)
Authors: Magain Nicolas , Tniong Camille , Goward Trevor , Niu Dongling , Goffinet Bernard , Sérusiaux Emmanuel , Vitikainen Orvo , Lutzoni François , Miadlikowska Jolanta 
Published: October 2018

AbstractThis comprehensive phylogenetic revision of sections Peltigera and Retifoveatae of the cyanolichen genus Peltigera is based on DNA sequences from more than 500 specimens from five continents. We amplified five loci (nrITS, β‐tubulin and three intergenic spacers part of colinear orthologous regions [COR]) for the mycobiont, and the rbcLX locus for the cyanobacterial partner Nostoc. Phylogenetic inferences (RAxML, BEAST) and species delimitation methods (bGMYC, bPTP, bPP) suggest the presence of 88 species in section Peltigera, including 50 species new to science, hence uncovering a surprisingly high proportion of previously unnoticed biodiversity. The hypervariable region in ITS1 (ITS1‐HR) is a powerful marker to identify species within sections Peltigera and Retifoveatae. Most newly delimited species are restricted to a single biogeographic region, however, up to ten species have a nearly cosmopolitan distribution. The specificity of mycobionts in their association with Nostoc cyanobionts ranges from strict specialists (associate with only one Nostoc phylogroup) to broad generalists (up to eight Nostoc phylogroups uncovered), with widespread species recruiting a broader selection of Nostoc phylogroups than species with limited distributions. In contrast, species from the P. didactyla clade characterized by small thalli and asexual vegetative propagules (soredia) associate with fewer Nostoc phylogroups (i.e., are more specialized) despite their broad distributions, and show significantly higher rates of nucleotide substitutions.
PERAN YPKP SEBAGAI KELOMPOK KEPENTINGAN (INTEREST GROUP) DALAM MEMERJUANGKAN HAK HAK KORBAN PERISTIWA G30S (Studi Kasus Aktivitas YPKP di Kabupaten Pati)
Authors: Wisnu Wardhani Adipta 
Published: October 2018

Indonesia is one of the countries that embraced democracy in system administration. Indonesia has proved it by holding presidential and vice presidential election directly. Besides the Indonesian people freely organizing meetings and talking freely to express opinions, criticism, or even overseeing the governance system. Freedom of religion is a manifestation of the democratic state.The dynamics of the Non-Governmental Organization (NGO) was born along with the birth of a new order of the early 1970s. The birth of this order to the economic development paradigm and focusing on economic growth, had an impact on short-term plans, medium and long-national development, which is implemented in the five year plan. NGO as a partner of government to accelerate the process of national development in all fields.This research will be directed to find out how YPKP activity as well as how the interaction / relationship dynamics YPKP with the Government. Murder Victims Research Foundation 1965/1966 (YPKP 65) is the organization's first victim in Indonesia fighting for the enforcement of human rights on Human Tragedy 1965/1966. YPKP 65 judging cases of crimes against humanity 1965/1966 has not been seriously considered in law and politics of the country. During the 12 years of reform, none of the political elite, both in Parliament and in the executive, even in the judiciary investigate cases in 1965.After analysis, it appears that YPKP 65 Pati Regency consolidate internally and externally by holding regular meetings so that the communication that exists among members of intertwined smoothly, as did the communications against similar organizations lainnya.YPKP 65 Pati regency using communication media / communication channels that are electronically for obtain information related to the organization's objectives. There was also the dynamics between YPKP with another NGO. Keywords: Role, Interest Groups, Dynamics.
EVALUASI PEMANFAATAN MEDIA SOSIAL BAGI PELAKSANAAN FUNGSI ANGGOTA DPRD JAWA TENGAH
Authors: Abdulrahman, dkk Wahid 
Published: October 2018

In order to improve the performance of Central Java Parliament, social media has been used as a tool that is easy, inexpensive, and could reach all segments throughout the region of Central Java. This study aimed to evaluate the use of social media in the implementation of the functions of legislators to communicate with the public. This research is a qualitative research with case study method. Capturing data through in-depth interviews to Central Java Parliament members who are active in social media and the public in their networks. The results of the study consisted of three things. First, social media is used by members of the Central Java Parliament for three reasons: (1) communicate the functions of the parliament (legislative, control, and budget); (2) communicate with the public in order to listen public needs and get feedback; (3) a means of self entertainment by using social media as a tool to express their selves and share personal information. Second, related to the function of the parliament which has been communicated through social media, the control function is the most frequent performed. While the legislative function performed moderately, and the budget function as the most rarely communicated. Third, public informants in social media networks of Central Java parliament members perceives the them as representatives of the people who actually work for the people. Keywords: social media, members of the board, the function of parliamen.
PEMBANGUNAN BERBASIS BUDAYA SEBAGAI STRATEGI PEMBANGUNAN KOTA: REVITALISASI PASAR GEDE DI KOTA SURAKARTA
Authors: Harsasto Priyatno 
Published: October 2018

This research aims to explore the role of community mobilisation in Surakarta’s culture-led urban regeneration process by analysing the case of the Pasar Gede area. This research argues that the generation and use of cultural resources in urban regeneration lie in community mobilisation and institutional support, rather than in a state-led cultural ﬂagship approach. In this way, local government needs to move beyond the instrumentalism of urban cultural strategies and to rediscover the spaces where local cultural activities and mobilization capacities are attached. Only through understanding the relationship between place and community mobilization will a benefit for the revitalization of a unique and historical urban area be gene
Mowa pacjentki z chorobą Parkinsona w fazie zaawansowanej
Authors: Szurek Mateusz 
Published: October 2018

The purpose of this article is to present speech disorders of 91 years old patient suffering from advanced Parkinson’s disease (it is the last stage of the disease when all symptoms are stronger) and to draw attention to the need of mentioning the impact of speech therapy while describing the disease. In the article an author is introducing the patient and her current condition. Mainly it is focused on the speech therapy diagnosis that was based on particular aspects of speech (such as: general condition of the patient, phonation, comprehension of speech and naming, repea- ting, dialogues and storytelling, reading, counting and writing). In the final part, the effectiveness of speech therapy is presented. This publication might become a leading example for other speech therapist on how to manage the therapy for people suffering from these types of disorders in speaking and communication.
Od nastoletniego macierzyństwa do życia w dorosłości w wypowiedziach kobiety z niepełnosprawnością intelektualną
Authors: Mach Aleksandra 
Published: October 2018

Maternity in the case of women with intellectual disabilities is exposed to many factors hindering its implementation. Research on this occurrence shows that one of the main reasons for that is insufficient or inept support for this group of women in different areas, such as educational, financial, informative, emotional. Teenage mothers with disabilities are in a particularly difficult situation. The article presents the analysis of statements of an adult woman with mild intellectual disability on her experience of teenage pregnancy as well as maternity as an adult woman. The humanistic attitude of giving the floor to the respondent allowed to determine other meaningful matters in the woman’s life (among others: relationships with life partners, relationship with the mother, vision of the future, financial situation) The methodology of research used was qualitative research. Two open interviews took place 8 months apart. The interviews were recorded to an electronic device. The material obtained was later transcribed. Triangulation of the sources was included (two family assistants were interviewed).
Kilka uwag o stanie badań nad kompetencją słowotwórczą dzieci z niepełnosprawnością intelektualną
Authors: Marciniak-Firadza Renata 
Published: October 2018

A description of the understanding (reception, decoding, interpretation) and creation (expression, coding) of word-building structures by children with minor intellectual disabilities, and a specification of how these word-building structures exist in the linguistic awareness of such children, is important as there exists no research and therefore no studies related to the word-building skills of children with intellectual disabilities.The only data related to word-building skills in children with intellectual disabilities available are the names of professions collected by A. Wątorek in her research on the linguistic competences responsible for the development of lexical skills. The data incorporated in the said study allowed the linguistic and wordbuilding analysis, and hence made it possible to indicate the methods of coding the names of professions/ persons performing certain activities by children with minor intellectual disabilities.
Kryzys rodziców dziecka z niepełnosprawnością w perspektywie nowych narzędzi normalizacyjnych
Authors: Doroszuk Joanna 
Published: October 2018

Social and cultural transformations determine the functioning of a disabled child’s family. The Internet, support groups or associations are the new normalisation tools parents can use. They can affect both the structure of his or her parenting as well as the process of coping in difficult situations. The author analyses the social and emotional situation of parents of children with disabilities, based on her research. They describe the significant categories and areas important for further scientific exploration.
Zachowania seksualne dzieci i młodzieży ze spektrum autyzmu. Wyniki badań pilotażowych
Authors: Wojciechowska Aneta , Gulczyńska Anna 
Published: October 2018

In the article the results of pilot studies concerning manifestation of sexuality in a group of children and youth with autism spectrum disorder were presented. The research is divided into two fundamental parts. In the first part – the shorter one, definitions and conceptions were outlined. The subject of sexuality and functioning of people with autism spectrum disorders regarding social behaviours was also discussed. In the second part, the findings of own studies conducted on a group of mothers of children and youth with autism spectrum disorder were presented.
Środowisko szkoły w narracjach uczniów z zespołem Aspergera – wnioski z badań
Authors: Moszyńska Małgorzata 
Published: October 2018

The article addresses the subject of social functioning of a student diagnosed with Asperger Syndrome in the environment of a mass education school, in his subjective opinion. Methodologically speaking it is based on qualitative studies and the aim of the research was to reach subjective significance given by the students with Asperger Syndrome to this institution and understanding the role it plays for them.
An Equal-Area Criterion Based Pulse Encoding Strategy for RF Switch-Mode Power Amplifier
Authors: Chen Jianbin , Yao Fuqiang , Zhang Jiang , Wei Zhihu 
Published: October 2018

Abstract
A novel pulse encoding strategy for RF switch-mode power amplifier (SMPA) is proposed in this paper to achieve benefits of multi-level delta-sigma modulators (DSM) while alleviating challenges that multi-level DSM brings to SMPA. The pulse encoder consists of a multi-level delta-sigma modulators (DSM) followed by a level transformation module (LTM). Based on the equal-area criterion, LTM directly maps the multi-level DSM pulse train into a binary pulse train which enables a simple system configuration. The feasibility and effectiveness of proposed strategy are verified by numerical simulation and experimental measurement. Results show that, with a similar coding efficiency, the proposed strategy obtains more than 7 dB improvement in average in-band signal to noise ratio (SNR) compared to traditional two-level DSM.
Research on Temporal Cloaked Signal Transmission Based on Time Reversal Technique
Authors: Zhou Hongcheng , Wang Bing-zhong , Wang Yu , Chen Weirong , Yan Zhongming 
Published: October 2018

Abstract
Based on the theory of time reversal technique and through the use of temporal dispersive delay lines, this paper presents a demonstration of temporal cloaked signal transmission at microwave frequencies. When compared with a conventional signal processing system, the related dispersive delay lines are not required to provide linear group delay response. Thus the proposal simplifies the system structure for temporal cloaking, avoids the drawbacks of easy detection, easy decoding and easy analysed brought by linear modulation system, and then strengthen the safety and reliability in signal transmission. Theoretical analysis and experimental results validate the proposed system. The proposed method and achieved results indicate potential application in secure communications and data multiplexing subject to channel bandwidth requirements.
Investigation of a new formaldehyde-free adhesive consisting of soybean flour and Kymene® 736 for interior plywood
Authors: Chen Nairong , Huang Jian , Li Kaichang 
Published: October 2018

Abstract
A combination of Kymene® 736 (K736) resin [a paper wet strength agent from reactions of hexamethylenediamine (HMDA) and epichlorohydrin (ECH)] and defatted soy flour (DSF) was investigated as a formaldehyde-free wood adhesive. In focus was the pH influence on the pot life of the adhesive and the water resistance of the plywood prepared with the new adhesive. It was found that the pH of the DSF-K736 adhesive had to be ≥11 before the resulting plywood panels could meet industrial water resistance requirements for interior plywood. The DSF/K736 weight ratio significantly affected the water resistance of the resulting 5-ply plywood. The 11/1 was the highest ratio that still enabled the plywood to meet the water resistance requirements. The hot-pressing temperature of ≥110°C and the hot-pressing time of ≥4 min resulted in 5-ply plywood panels with water resistance properties. The probable mechanism is that K736 reacts with nucleophilic groups in DSF and highly crosslinked adhesive networks are formed. This supposition is supported by the presence of an ester band in the Fourier-transform infrared (FTIR) spectrum of the cured DSF-K736 adhesive.
Evil, the Laws of Nature, and Miracles
Authors: Huxford George 
Published: October 2018

Abstract
This paper takes a less trodden path in its approach to Kant’s philosophy of religion. Rather than a detailed study of his mature works on the subject, some of his pre-Critical works are examined. These reveal what I hold to be four foundations which remain unchanged through Kant’s philosophical career and thus act to hold up his later work on the subject. The main body of the paper is presented in two parts. In the first, we see that Kant finds that in addition to evil as limitation, there is now evil which is ontologically positive. The second part is devoted to Kant’s considerations of what was termed “physical evil”. He finds that this is neither an evil nor any form of divine punishment but rather those consequences of the laws of nature which are harmful to humans. Further, God does not intervene with the workings of these laws of nature which He has put in place but guarantees their continuity. However, it will be shown that such non-interference is problematic for Kant’s mature stance on miracles.
Kant on Contradiction, Conceptual Content, and the Ens Realissimum
Authors: Oberst Michael 
Published: October 2018

Abstract
Kant assents to Leibniz’s claim that purely positive concepts cannot contradict each other. Albeit counter-intuitive, this claim is well-grounded in Kant’s views on contradiction and conceptual content. First, according to Kant, a contradiction only occurs if a predicate is affirmed and negated; second, all concepts except of those that pertain to God covertly contain negative marks. Although I shall argue that Kant’s account fails, it is still interesting in that it tackles an overlooked problem, namely how implicit contradictions are possible.
The crystal structure of 2,3-dimethyl-1,4-dinitrobenzene – a Z′ = 4 structure, C8H8N2O4
Authors: Fanfan Shen , Shaomin Xue , Jianlong Wang 
Published: October 2018

Abstract
C8H8N2O4, triclinic, P1̄ (no. 2), a = 9.1093(5) Å, b = 13.2430(8) Å, c = 15.4334(10) Å, α = 106.544(2)°, β = 98.150(2)°, γ = 96.151(2)°, V = 1745.22(18) Å3, Z = 8, R
gt(F) = 0.0508, wR
ref(F
2) = 0.1141, T = 173(2) K.