bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Funeral by M. James
Authors: Liu Yina 
Published: June 2019

James, Matt. The Funeral. Groundwood Books-House of Anansi Press, 2018.
The Funeral, written by Matt James, focuses on a day that Norma goes to her Uncle Frank’s funeral. While this book will appeal to children, it is also good for adults to look at something heavy in life, such as a funeral, through a child’s eye.
In a relaxed tone and cozy painting style, the story starts with Norma finding out that she won’t have to go to school on the day of her uncle’s funeral. She is excited about the day off and the “plan” of the day, playing with her cousin. Throughout the funeral, the story is developed through Norma’s eyes, showing how she experiences the time with her cousin. Before Norma leaves the funeral, she thinks Uncle Frank would have loved his funeral, since she noticed he was smiling right at her in his photo.
Instead of a heavy, didactic teaching of the meaning of death, Matt explores a delicate way to describe a funeral from a child’s perspective. For example:
There was a little flag [which said FUNERAL] on the car that drove them to the church. Norma tried to sound out the word printed on it.“F-U-N,” she said.And then she said it again.
Matt James, a Canadian artist, is an illustrator of many picture books. With this picture book, James debuts as a writer and illustrator. The illustrations of the book are mostly acrylic and ink on masonite. Also, this book is the first time he combined a few digital pieces on the background illustrations. This book would tie in perfectly to a classroom talk about funerals and similar occasions and illustrates what a funeral is like from a child’s perspective.
Highly Recommended: 4 out of 4 starsReviewer: Yina Liu
Yina Liu is a first year PhD student in Language and Literacy, in the department of Elementary Education. Her research interests are digital literacies and children's literature, especially digital picture books. She finished her Master's degree at the University of Saskatchewan and worked in a preschool classroom as an early childhood educator for a year in Saskatchewan.
Florette by A. Walker
Authors: Petrunia Sara 
Published: June 2019

Walker, Anna. Florette. Illustrated by Anna Walker, Clarion Books, 2018.
Written and illustrated by Anna Walker, this picture book’s fresh, beautiful watercolour images match the joyful feeling this story will leave you with. Follow Florette on her quest through a sterile city to find a garden in place of the one she left behind in her family’s move. Not only did she leave behind a garden filled with apple trees and butterflies but also all her friends and fun adventures. Find out how Florette navigates this new world and finds joy in her own way not only for herself, but for everyone around her.
This book compels readers to consider the world surrounding them and what it might be missing. Its illustrations emphasize the stark difference in feeling between the man-made and natural worlds while suggesting a beautiful way to combine the two. The text is simple and expanded upon using emotive pictures, making this book an easy, satisfying read for young and old readers alike.
Although Florette does not openly talk about her feelings, we can observe the loneliness that follows the character in this new city surrounded by packing boxes and concrete. This book would resonate with any child who has felt that loneliness in any sense of the word and offers an easy solution of seeking out those things that bring us joy.
A beautiful fusion of friendship and nature, open this book and watch something meaningful grow.
Recommended: 3 out of 4 starsReviewer: Sara Petrunia
Sara Petrunia is a University of Alberta undergraduate student excited to use literature in her future elementary classrooms. When she is not preoccupied with her studies, Sara is busy working as a hairdresser or enjoying a trip somewhere far away!
Social Traditions and the Violation of Women’s Right in the Tagin Society of Arunachal Pradesh
Authors: Raji Bijay 
Published: June 2019

There are 26 major tribes and 110 sub tribes in Arunachal Pradesh. Out of these tribes and sub tribes, Tagin is one of the major tribes in Arunachal Pradesh. The Tagin are descendants of Abo Tani<sup>.</sup> They are settled in Upper Subansiri District of Arunachal Pradesh, bordering east with Galo, west south with Nyishi and North with the Tibet (China). The Tagins are recognized as a separate tribal group very lately. Macknise had noted thatDafla living on the border of North Lakhimpur was known as Tagin Dafla.<sup> </sup> “Till very recently the Bagins, a Western branch of the Dafla tribe, occupying wild terrain in the east of Kameng and west of the Subansiri call the Daflas across the frontier of the Kameng district Tagins. Here, the term Tagin implies the sense of being an eastern people”.
Teaching Cortical-Screw Tightening
Authors: Buck J. Stewart , Wally Meghan K. , Patt Joshua C. , Scannell Brian , Seymour Rachel B. , Hsu Joseph R. 
Published: June 2019

Background:
Cortical-screw insertion is a fundamental skill in orthopaedic surgery, yet, to our knowledge, no standardized method of teaching this skill exists. The purpose of this study was to evaluate a training protocol that was designed to teach residents how to tighten a cortical screw without causing any stripping.

Methods:
Twenty-five residents and 8 attending surgeons from an orthopaedic residency program tightened cortical screws in a synthetic bone model with a digital torque screwdriver using 3 different techniques: percutaneous; open, dominant hand; and open, nondominant hand. The residents then participated in a training protocol during which each tightened additional screws while receiving real-time torque feedback. During training, the residents targeted 50% to 70% of the stripping torque for each screw. They were assessed at baseline, immediately after training, and at 12 to 15 weeks after training. During each assessment, the percentage of screws that were tightened in the target range and the percentage of stripped screws were recorded. The costs of the training protocol were assessed.

Results:
After training, all of the residents tightened screws with lower insertional torque compared with their baseline, but only the senior residents tightened more screws in the target range and stripped fewer screws. The attending surgeons, when compared with the residents at baseline, tightened more screws in the target range and tended to strip fewer screws, but these differences were absent at final testing. Costs included $1,927 for durable equipment and an estimated $74 per resident per training session for consumable goods.

Conclusions:
The senior residents inserted more screws in the target range and stripped fewer screws after participating in this training protocol, but the junior residents did not show significant improvement. Implementation of this training protocol for all residents may improve clinical performance but, because our sample size was limited, additional study is required to assess skill transfer to clinical practice.

Clinical Relevance:
Cortical-screw tightening is a fundamental skill in orthopaedics, and completion of this torque-directed training protocol may accelerate residents’ skill acquisition.
Bone Repair Using the Masquelet Technique
Authors: Masquelet Alain , Kanakaris Nikolaos K. , Obert Laurent , Stafford Paul , Giannoudis Peter V. 
Published: June 2019

➤ The optimal time for the second stage is between 4 and 8 weeks.➤ Multiple tissue biopsy specimens must be sent for microbiological analysis during both stages of the procedure.➤ Recurrence of infection requires debridement of the membrane and surrounding soft tissues and reinitiation of the technique (return to first stage).➤ The bone graft utilized is autologous cancellous pieces or filtered reamer-irrigator-aspirator graft, which can be expanded further with osteoconductive, osteoinductive, and osteogenic material.➤ Bone healing of the defect is independent of its size.
Aseptic Glenoid Baseplate Loosening After Reverse Total Shoulder Arthroplasty
Authors: Rojas Jorge , Choi Kyubo , Joseph Jacob , Srikumaran Uma , McFarland Edward G. 
Published: June 2019

Background:
Aseptic glenoid baseplate loosening can lead to the failure of reverse total shoulder arthroplasty (RTSA). Estimates of the prevalence of aseptic glenoid baseplate loosening after RTSA are required to guide clinical decisions, but published results are variable and lack precision. The goal of this meta-analysis was to determine a precise estimate of the prevalence of aseptic glenoid baseplate loosening after RTSA and to explore variation in the prevalence according to different variables, such as the type of procedure (primary or revision), preoperative diagnosis, the center of rotation of the glenoid component (medialized or lateralized), study size, the definition of aseptic glenoid baseplate loosening, and the duration of follow-up.

Methods:
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. We searched the MEDLINE and Embase databases for English-language articles describing the outcomes after RTSA with a minimum 12-month follow-up in which radiographic findings of aseptic glenoid baseplate loosening were reported. Random-effects meta-analysis was performed, and meta-regression was used to explore the influence of variables on heterogeneity. Subgroup analyses and sensitivity analyses were performed.

Results:
One hundred and three studies (covering 6,583 RTSAs) performed from 1991 to 2015 met our inclusion criteria. The pooled prevalence of radiographic aseptic glenoid baseplate loosening for all RTSAs was 1.16% (95% confidence interval [CI], 0.80% to 1.69%). The prevalence of aseptic glenoid baseplate loosening was lower among primary RTSAs (0.90%; 95% CI, 0.54% to 1.49%) than among revision RTSAs (3.64%; 95% CI, 1.91% to 6.84%). The pooled prevalence of aseptic glenoid baseplate loosening by diagnosis was 2.69% for osteoarthritis with bone loss, 1.71% for cuff tear arthropathy, 1.20% for rheumatoid arthritis, 1.08% for sequelae of fracture, 0.94% for irreparable massive cuff tear, and 0.25% for acute proximal humeral fracture. The prevalence of aseptic glenoid baseplate loosening was not significantly different for prostheses with a medialized center of rotation (1.15%) versus a lateralized center of rotation (1.84%).

Conclusions:
To our knowledge, the present study represents the first meta-analysis investigating only aseptic glenoid baseplate loosening after RTSA. Multiple variables were found to be associated with the prevalence of aseptic glenoid baseplate loosening. The rates reported here are lower than those reported previously because of the inclusion of more recent evidence and more studies that evaluated aseptic glenoid baseplate loosening.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Barriers from calling ambulance after recognizing stroke differed in adults younger or older than 75 years old in China
Authors: Li Shengde , Cui Li-Ying , Anderson Craig , Gao Chunpeng , Yu Chengdong , Shan Guangliang , Wang Longde , Peng Bin 
Published: June 2019

Abstract
Background

As health behavior varies with increasing age, we aimed to examine the potential barriers in calling emergency medical services (EMS) after recognizing a stroke among 40-74- and 75-99-year-old adults.

Methods

Data were obtained from a cross-sectional community-based study (FAST-RIGHT) that was conducted from January 2017 to May 2017 and involved adults (age ≥40 years) across 69 administrative areas in China. A subgroup of residents (153675) who recognized stroke symptoms was analyzed. Multivariable logistic regression models were performed in the 40-74 and 75-99 age groups, separately, to determine the factors associated with wait-and-see behaviors at the onset of a stroke.

Results

In the 40-74 and 75-99 age groups, the rates of participants who chose “Self-observation at home” were 3.0% (3912) and 3.5% (738), respectively; the rates of “Wait for family, then go to hospital” were 31.7% (42071) and 33.1% (6957), respectively. Rural residence, living with one's family, low income (<5000 RMB per annum), having a single avenue to learn about stroke, and having friends with stroke were factors associated with waiting for one's family in both groups. However, unlike in the 40-74 age group, sex, number of children, family history, and stroke history did not influence the behaviors at stroke onset in the 75-99 age group.

Conclusions

Different barriers from recognizing stroke and calling an ambulance exist in the 40-74 and 75-99 age groups. Different strategies that mainly focus on changing the “Wait for family” behavior and emphasize on immediately calling EMS are recommended for both age groups.
Analyzing the interactions of circRNAs, miRNAs, and mRNAs to predict ceRNA networks in human acute type A aortic dissection
Authors: huang maoxun , piao hulin , wang yong , wang weitie , li bo , zhu zhicheng , xu rihao , li dan , wang tiance , liu kexiang 
Published: June 2019

Abstract
Background: Acute type A aortic dissection(ATAAD) is a life-threatening vascular disease. However, its underlying mechanism is still not well understood. Here, circular RNAs(circRNAs) were shown to function as competitive endogenous RNAs (ceRNAs) to regulate the effect of microRNAs(miRNAs) on their target genes may play a critical role in ATAAD. However, comprehensive identification and integrated analysis of the circRNA-miRNA-mRNA network in ATAAD have not been performed.
Results: The gene expression profile of circRNAs, miRNAs, and mRNAs was performed between 6 ATAAD patients and 6 age-matched normal ascending aortic wall tissues patients were analyzed using the Arraystar human RNAs microarray. We identified that the expression of 12576 circRNAs,1603 miRNAs, and 14596 mRNAs were found to be differentially expressed(DE). Gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes pathway analyses(KEGG) were performed on these DE mRNAs and miRNA-mediated target genes of circRNAs. Furthermore, we used a multi-step computational framework and several bioinformatics methods to construct a ceRNA network containing circRNAs, miRNAs, and mRNAs based on co-expression analysis between the DE genes. The constructed ceRNA regulatory network containing 25 circRNAs, 17 miRNAs and 72 mRNAs. In the whole ceRNA network. We identified that plenty of key genes, such as hsa_circRNA_404522, hsa_circRNA_0022920, hsa_circ_0075881, hsa-miRNA1285-3p, hsa-miRNA-1285-3p, hsa-miRNA-637, hsa-miRNA-650, TINAGL1, JPH4, PLXNA2, TGFBR1, and THSD4. Furthermore, we also integrated the circRNA-miRNA-mRNA regulatory modules of the key genes.
Conclusions: This study found a profile of dysregulated circRNAs, miRNA and mRNAs, and competitive circRNA-miRNA–mRNA regulatory networks were comprehensively integrated and predicted to be involved in ATAAD by GO and KEGG pathway analysis. It might be prospective clinical markers associated with ATAAD, and it is worthwhile to perform further studies to reveal the underlying link between these key genes and the molecular mechanisms of AD.

Keywords：aortic dissection; circRNAs; miRNAs; mRNAs; ceRNA
Acupuncture with Rehabilitation in the Treatment of Ischemic Stroke Recovery: A Randomized Controlled Trial
Authors: Li Lixia , Zhu Weifeng , Lin Guohua , Chen Chuyun , Tang Donghui , Lin Shiyu , Weng Xiaorong , Xie Liqin , LU Lihong , Li Weilin 
Published: June 2019

Abstract
Background: Acupuncture is a well known treatment for ischemic stroke recovery, but evidence of its effectiveness remains limited.
Methods: Rehabilitation training was provided to a control group. In Arm 1 and Arm 2, acupoint schemes were determined by a consensus of acupuncture experts and previous clinical research. Arm 1 was based on an acupoint summary of ancient literature, and Arm 2 was based on the summary of effective acupuncture points from modern RCT literature. Acupuncture was given on the acupoint. After acupuncture, the needles were left in for 30 minutes, and checked every 10 minutes. The three groups received treatment once a day, 5 times a week, for 2 weeks. The primary outcome was the National Institute of Health stroke scale (NIHSS), and the secondary outcomes were the Barthel index (BI) and the modified Ashworth scale (MAS). Outcomes were observed in patients both before and after treatment.
Results: A total of 497 patients with ischemic stroke were randomized into either Arm 1 (159 cases), Arm 2 (173 cases) or a control group (165 cases). After 2 weeks of treatment, the NIHSS scores for Arm 1 were lower than those of the control group (P=0.017); the BI scores were higher in Arm 2 than they were in the control group (P=0.020). Additionally, there was no significant difference between Arm 1 and the control group for either the BI scores or the modified Ashworth scale scores (P>0.05).
Conclusion: The clinical efficacy of Arm 1 and Arm 2 (acupuncture groups) was superior to that of the control group.
Efficacy of acetaminophen with and without oxycodone for analgesia in nonoperative treatment of extremity fractures in adults: Protocol for a double-blind randomized clinical trial
Authors: Gao Tao , Zhu Hongyi , Zhang Changqing , Chai Yimin , Guo Cheng , Zhu Xiaozhong , Bao Bingbo , Li Xingwei , Lin Junqing , Zheng Xianyou 
Published: June 2019

Abstract
Background: Opioids and acetaminophen are both widely used to relieve pain after nonoperative treatment of limb fractures, but evidence for superiority of opioids versus acetaminophen is lacking. In this study we aim to determine whether acetaminophen is noninferior to the acetaminophen/oxycodone combination for pain relief after nonoperative fixation of an extremity limb fracture. We hypothesize that acetaminophen is noninferior to the acetaminophen/oxycodone combination.
Methods: A double-blind, randomized controlled trial will be conducted. Power analysis determined that 1,226 participants will be needed (p<0.05, power 90%). Patients with acute limb fracture who receive nonoperative treatment will be recruited and randomly allocated into two groups: the intervention group will receive oral oxycodone (10 mg)/acetaminophen (650 mg), and the control group will receive acetaminophen (650 mg) only. All participants will be instructed to take one pill of study medication on an as-needed basis and no more frequently than once every 8 hours. The primary outcome measure will be scores on the 11-point Numeric Rating Scale (NRS-11) over 14 days. Secondary outcome measures are scores on the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), EuroQol five dimensions’ questionnaire (EQ-5d), self-rated satisfaction with the analgesia produced, self-reported nighttime sleep duration, number of intervention or control pills used, total duration for taking intervention or control medication. Change of pain scores and the number of times that analgesic drugs were taken in the two groups will be statistically evaluated with t-student tests according to their fracture site.
Discussion: This study will be a randomized controlled trial that is adequately powered to test the hypothesis that acetaminophen is noninferior to the combination of acetaminophen and oxycodone in relieving objectively measured pain after nonoperative treatment of limb fractures in adults. It is hopeful to provide a safe and effective analgesic plan for such patients.
Trial registration numbers: ChiCTR registry: ChiCTR1800017015 ( http://www.chictr.org.cn/showproj.aspx?proj=28612). Registered on 8 July 2018.
HetEnc: A Deep Learning Predictive Model for Multi-type Biological Dataset
Authors: Wu Leihong , Liu Xiangwen , Xu Joshua 
Published: June 2019

Abstract
Background: Researchers today are generating unprecedented amounts of biological data. One trend in current biological research is integrated analysis with multi-platform data. Effective integration of multi-platform data into the solution of a single or multi-task classification problem; however, is critical and challenging. In this study, we proposed HetEnc, a novel deep learning-based approach, for information domain separation.

Results: HetEnc includes both an unsupervised feature representation module and a supervised neural network module to handle multi-platform gene expression datasets. It first constructs three different encoding networks to represent the original gene expression data using high-level abstracted features. A six-layer fully-connected feed-forward neural network is then trained using these abstracted features for each targeted endpoint. We applied HetEnc to the SEQC neuroblastoma dataset to demonstrate that it outperforms other machine learning approaches. Although we used multi-platform data in feature abstraction and model training, HetEnc does not need multi-platform data for prediction, enabling a broader application of the trained model by reducing the cost of gene expression profiling for new samples to a single platform. Thus, HetEnc provides a new solution to integrated gene expression analysis, accelerating modern biological research.
Perioperative anaesthetic management of patients with or at risk of acute distress respiratory syndrome undergoing emergency surgery
Authors: Battaglini Denise , Robba Chiara , Rocco Patricia Rieken Macêdo , De Abreu Marcelo Gama , Pelosi Paolo , Ball Lorenzo 
Published: June 2019

Abstract
Patients undergoing emergency surgery may present with the acute respiratory distress syndrome (ARDS) or develop this syndrome postoperatively. The incidence of ARDS in the postoperative period is relatively low, but the impact of ARDS on patient outcomes and healthcare costs is relevant [1]. The development of ARDS as a postoperative pulmonary complication (PPC) is associated with prolonged hospitalisation, longer duration of mechanical ventilation, increased intensive care unit length of stay and high morbidity and mortality [2]. In order to mitigate the risk of ARDS after surgery, the anaesthetic management and protective mechanical ventilation strategies play an important role. In particular, a careful integration of general anaesthesia with neuraxial or locoregional techniques might promote faster recovery and reduce opioid consumption. In addition, the use of low tidal volume, minimising plateau pressure and titrating a low-moderate PEEP level based on the patient’s need can improve outcome and reduce intraoperative adverse events. Moreover, perioperative management of ARDS patients includes specific anaesthesia and ventilator settings, hemodynamic monitoring, moderately restrictive fluid administration and pain control. The aim of this review is to provide an overview and evidence- and opinion-based recommendations concerning the management of patients at risk of and with ARDS who undergo emergency surgical procedures.