bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Muskox and the Caribou by N. Mike
Authors: Aitken Leslie 
Published: September 2019

Mike, Nadia. The Muskox and the Caribou. Illustrated by Tamara Campeau. Iqaluit, Nunavut, Inhabit Media, 2017.
In simple, sensitive, and well-structured prose, Nadia Mike relates the story of a lost muskox calf that is adopted by a female caribou. Her own fawn, like the other newborns in the herd, is short haired, long legged, and agile. The musk ox calf, by comparison, is shaggy, stocky, and stumpy. The herd’s young caribou tend either to ignore or reject him. The doe, however, instinctively protects him until he is mature enough to find his way to a muskox herd.
The story is not sentimentalized; neither is it excessively anthropomorphized. Admittedly, the young caribou “giggle” as the muskox attempts to splash in the pond with them and the little muskox wonders, “Why do they make fun of me?” Anthropomorphizing to this degree seems reasonable in conveying to young children that animals of one species are instinctively cautious, sometimes hostile, toward those of another.
Mike’s storyline is expertly enhanced by the line drawings and delicate colour palette of Tamara Campeau. An experienced wildlife illustrator, Campeau presents a realistic picture of both Canada’s tundra, and the animals which inhabit it in spring and summer.
As well as a heart-warming story, there is an introduction to the natural sciences here, an opportunity to discuss the concept of species, to study a little further our northern ecosystems, and to explore the mothering instinct that leads a female of one species to temporarily adopt the infant(s) of another.
Primary school teachers, school and public librarians, and parents across the nation would find this book an excellent introduction to the nature and culture of Canada’s Arctic. Hats off to Nunavut’s first independent publishing house for this fine piece of children’s literature.
Highly recommended: 4 out of 4 starsReviewer: Leslie Aitken
Leslie Aitken’s long career in librarianship involved selection of children’s literature for school, public, special and academic libraries. She was formerly Curriculum Librarian for the University of Alberta.
Metastatic Renal Cell Carcinoma to the Spine and the Extremities
Authors: Louie Philip K. , Sayari Arash J. , Frank Rachel M. , An Howard S. , Colman Matthew W. 
Published: September 2019

» Approximately 50% of patients with renal cell carcinoma (RCC) will present with an osseous metastasis (30% to the spine), resulting in substantial pain, neurologic dysfunction, or pathologic fractures.» RCC metastases have traditionally been difficult to manage because of their large, highly destructive, hypervascular nature; they are relatively resistant to chemotherapy and radiation therapy.» In the spine, surgery ranging from decompression with internal fixation to total en bloc spondylectomy has been described. In the extremities, excision of the lesion with reconstruction using internal fixation or an endoprosthesis often is recommended.» Given the vascular nature of the tumor, preoperative angiography and embolization reduce intraoperative blood loss. Debate continues regarding the proper comprehensive treatment for these patients.» With the development of targeted therapies for metastatic RCC, improved survival has been shown, but the long-term effect of these agents is relatively unknown.
Combining Geomechanical Model and Lattice Boltzmann Method LBM for the Characterization of Pore-Scale Stress
Authors: Al-Jindan Jana , Al-Ruwaili Khalid , Noui-Mehidi Mohamed Nabil 
Published: September 2019

Abstract
Fluid flow invasion is governed by the characteristics of the pore structure in the porous media. The flow is restricted due to the increase of net stresses near borehole after drilling. Understanding the fluid flow at the pore scale becomes an important aspect of successful operations such as matrix acidizing or fluid formation treatment. The aim of this work is to demonstrate the ability of using Lattice-Boltzmann formulations to solve the complex fluid flow system in the porous medium as compared to a Darcy type of flow analysis using geomechanical approaches. The simulations were performed at the same physical scale. The reduction of pore size at the vicinity of the borehole is approximated using different geometrical domains to mimic the fluid invasion process as a result of change in net stresses.
Genomic content of chemosensory genes correlates with host range in wood-boring beetles (Dendroctonus ponderosae, Agrilus planipennis, and Anoplophora glabripennis)
Authors: Andersson Martin N. , Keeling Christopher I. , Mitchell Robert F. 
Published: September 2019

Abstract
Background
Olfaction and gustation underlie behaviors that are crucial for insect fitness, such as host and mate selection. The detection of semiochemicals is mediated via proteins from large and rapidly evolving chemosensory gene families; however, the links between a species’ ecology and the diversification of these genes remain poorly understood. Hence, we annotated the chemosensory genes from genomes of wood-boring coleopterans, and compared the gene repertoires from stenophagous species with those from polyphagous species.

Results
We annotated 86 odorant receptors (ORs), 60 gustatory receptors (GRs), 57 ionotropic receptors (IRs), 4 sensory neuron membrane proteins (SNMPs), 36 odorant binding proteins (OBPs), and 11 chemosensory proteins (CSPs) in the mountain pine beetle (Dendroctonus ponderosae), and 47 ORs, 30 GRs, 31 IRs, 4 SNMPs, 12 OBPs, and 14 CSPs in the emerald ash borer (Agrilus planipennis). Four SNMPs and 17 CSPs were annotated in the polyphagous wood-borer Anoplophora glabripennis. The gene repertoires in the stenophagous D. ponderosae and A. planipennis are reduced compared with those in the polyphagous A. glabripennis and T. castaneum, which is largely manifested through small gene lineage expansions and entire lineage losses. Alternative splicing of GR genes was limited in D. ponderosae and apparently absent in A. planipennis, which also seems to have lost one carbon dioxide receptor (GR1). A. planipennis has two SNMPs, which are related to SNMP3 in T. castaneum. D. ponderosae has two alternatively spliced OBP genes, a novel OBP “tetramer”, and as many as eleven IR75 members. Simple orthology was generally rare in beetles; however, we found one clade with orthologues of putative bitter-taste GRs (named the "GR215 clade"), and conservation of IR60a from Drosophila melanogaster.

Conclusions
Our genome annotations represent important quantitative and qualitative improvements of the original datasets derived from transcriptomes of D. ponderosae and A. planipennis, facilitating evolutionary analysis of chemosensory genes in the Coleoptera where only a few genomes were previously annotated. Our analysis suggests a correlation between chemosensory gene content and host specificity in beetles. Future studies should include additional species to consolidate this correlation, and functionally characterize identified proteins as an important step towards improved control of these pests.
A Retrospective Study of the Clinical Phenotype and Predictors of Survival in non-Caucasian Hispanic Patients with Amyotrophic Lateral Sclerosis.
Authors: Sánchez-Martínez Claudia Marisol , Choreño-Parra José Alberto , Nuñez-Orozco Lilia , Placencia-Álvarez Noel Isaías , Alvis-Cataño Laura Marcela , Guadarrama-Ortiz Parmenides 
Published: September 2019

Abstract
Background. Little is known about the clinical phenotype of amyotrophic lateral sclerosis (ALS) in non-Caucasian populations. Here, we aimed to describe the clinical characteristics, prognostic factors and survival of Mexican patients with ALS.
Methods. We conducted a retrospective study by reviewing the medical records of patients with ALS that attended and were regularly followed at a third level hospital in Mexico City from 2000 to 2015. We calculated absolute and relative frequencies of the clinical characteristics from all the participants. We also estimated correlation coefficients between clinical features and overall survival. Additionally, survival rates were compared for all participants grouped according to different clinical features using the Kaplan-Meier method and the log-rank test.
Results. We enrolled 45 ALS patients, 53.33% had spinal-onset ALS and 46.66% presented bulbar ALS. The male/female ratio was 0.8. The mean age at onset of symptoms was 58.11 years. Mean survival time from onset was 64.73 ± 34.83 months. Cumulative survival rate after 5 years of disease onset was 44.44%. Age at onset and age at diagnosis inversely correlated with overall survival time. Also, we found that bulbar-onset, short diagnostic delay, percutaneous endoscopic gastrostomy, mechanical ventilation, and lower total cholesterol serum levels were associated with short survival.
Conclusions. The clinical characteristics of Mexican ALS patients differ from the disease phenotype observed in Caucasians. Nonetheless, the predictive value of certain well-recognized prognostic factors remains consistent in our population. The current study provides relevant information for a better understanding of prognostic factors in ALS patients from Mexico and other Latin American countries.
Weight Management Merits Attention in women with infertility: A Cross-Sectional Study on the Association of Anthropometric Indices with Hormonal Imbalance in a Ghanaian Population
Authors: Owiredu William K.B.A. , Ofori Peter Ntim , Turpin Cornelius Archer , Obirikorang Christian , Acheampong Emmanuel , Anto Enoch Odame , Owiredu Eddie-Williams , Adu Evans Asamoah 
Published: September 2019

Abstract
Objective: This study determined the association of anthropometric indices with hormonal imbalance among infertile women in a Ghanaian population.
Results: Follicle stimulating hormone (FSH) levels (18.47 vs 8.67, p-value =0.002), and luteinizing hormone (LH) (12.43 vs 8.01, p-value =0.044) were higher in women with primary infertility compared with women presenting with secondary infertility. Waist circumference (WC) and waist-to-height ratio (WHtR) showed significant negative partial correlation with prolactin in both primary and secondary infertile women. Also a significant negative partial correlation was observed between BMI and prolactin in secondary infertile women only. Waist-to-hip ratio (WHR) showed a positive association with LH in both primary and secondary infertility. WHR also showed significant positive correlation to LH/FSH ratio in secondary infertility whereas body adiposity index (BAI) showed a negative correlation to LH/FSH ratio. In a correlation analysis of anthropometric measures with hormonal profile and causes of infertility as a fixed factor, the association between anthropometric indices and fertility hormones was largely dependent on the underlying causes of infertility.
Efficacy of ultrasound-guided rectus sheath block, butorphanol for single-incision laparoscopic cholecystectomy: A prospective, randomized, clinical trial
Authors: Fu Huimin , Zhong Chaochao , Gao Yongtao , Xu Xingguo 
Published: September 2019

Abstract
Background: Whether rectus sheath block (RSB) combined with butorphanol can relieve incision pain and visceral pain in patients undergoing single-incision laparoscopic cholecystectomy (SILC) remains unknown. The goal of this study was to assess the efficacy of ultrasound-guided bilateral RSB, butorphanol on postoperative analgesia in patients undergoing SILC. Methods: All 116 patients who met the criteria were randomly divided into four groups: (Ⅰ) (n=29) general anesthesia combined with patient controlled intravenous analgesia (PCIA) (sufentanil 100ug); (Ⅱ) (n=29) general anesthesia combined with PCIA (butorphanol 8mg); (Ⅲ) (n=29) ultrasound-guided RSB combined with PCIA (sufentanil 100ug). (Ⅳ) (n=29) RSB combined with PCIA (butorphanol 8mg). Outcomes included visual analog scale (VAS) scores of incisional and visceral pain at rest and cough at 2,6,12 and 24h postoperatively, if a patient’s pain score＞3, then butorphanol 2mg was administered intravenously. the dose of butorphanol and opioids, the pressing numbers of PCIA, the length of hospital stay and the incidence of postoperative adverse events. Results: Both rest and cough pain scores were lower during first 2,6 hours in group Ⅲ than groupⅠ, similarly, group Ⅳwas significantly lower than groupⅡ. GroupⅠneeded more butorphanol as rescue analgesic for pain relief than group Ⅲ, group Ⅳ was better than group Ⅱ. In the above pairwise comparisons, it was clear that group Ⅲ and group Ⅳ had lower VAS scores. VAS scores of visceral pain was lower in groupⅡ at 2, 6 and 12 h after surgery compared with the groupⅠ. In the both groups Ⅲ and Ⅳ, the group Ⅳ was also lower than groupⅢ. Overall, RSB combined with PCIA (butorphanol 8mg) is the best match. Conclusions: Ultrasound-guided RSB combined with butorphanol can provide sufficient pain treatment after SILC. Trial registration: The study was registered prospectively with the Chinese Clinical Trial Registry（reg no.ChiCTR1900020738), obtained ethics committee of Affiliated Hospital of Nantong University approval (approved number: 2018-K067).
Endoscopic treatment of leaks and strictures after laparoscopic one anastomosis gastric bypass
Authors: Younis Fadi , Shnell Mati , Gluck Nathan , Abu-Abeid Subhi , Eldar Shai , Fishman Sigal 
Published: September 2019

Abstract
Background: Laparoscopic one anastomosis gastric bypass has become a prominent bariatric procedure. Yet, early and late complications, primarily leaks and strictures, are not uncommon. This study summarizes our experience with endoscopic treatment of laparoscopic one anastomosis gastric bypass complications. Methods: This is a retrospective study of consecutive patients referred to our hospital from 2015 to 2017 with post laparoscopic one anastomosis gastric bypass complications. Therapy was tailored to each case, including fully covered self-expandable metal stents, fibrin glue, septotomy, internal drainage with pigtail stents, through-the-scope and pneumatic dilation. Success was defined as resuming oral nutrition without enteral or parenteral support or further surgical intervention. Results: Nine patients presented with acute or early leaks: 5 (55.6%) had staple-line leaks, 3 (33.3%) had anastomotic leaks and 1 (11.1%) had both. All were treated with stents. Adjunctive endoscopic drainage was applied in 4 patients (44.4%). Overall 5 patients (55.6%) with acute/ early leaks recovered completely, including all 3 patients with anastomotic leak and the patient with both leaks but only 1/5 with staple line leak (20%). Complication rate in the leak group reached 22.2%. Eight patients presented with strictures, 7 at the anastomosis and one due to remnant stomach misalignment. All anastomotic strictures were dilated successfully. However, the patient with the pouch stricture required conversion to Roux-en-Y gastric bypass after 3 failed attempts of dilatation. Conclusion: Endoscopic treatments of laparoscopic one anastomosis gastric bypass complications are relatively effective and safe. Anastomosis-related complications are more amenable to endoscopic treatment compared to staple line leaks.
Comparing the sciatic nerve block quality of anterior and posterior approaches: A randomised trial
Authors: Yektaş Abdulkadir , Balkan Bedih 
Published: September 2019

Abstract
Background: The co-administration of sciatic nerve and femoral nerve blocks may provide anaesthesia and analgesia in patients undergoing lower extremity surgeries. Several approaches to sciatic nerve block have been described, including anterior and posterior approaches. Methods: Our study included 58 patients, randomly assigned to receive either an anterior (Group A, n = 29) or posterior (Group P, n = 29) approach. After the blocks were performed, we determined sensory and motor block start and end times, the time to first intraoperative fentanyl administration, the total dose of fentanyl required, the time to first diclofenac sodium administration, and the total dose of diclofenac sodium required. The date of trial registration was retrospectively registered in 11.07.2018Results: Comparison of the two groups revealed that Group P exhibited significantly shorter times to starting the sensory block (12.88±4.87 min for Group A, 7.70±2.05 min for Goup P) p=0.01 and first fentanyl administration (29.20±27.79 min for Group A, 4.05±7.47 min for Group P) p=<0.01, and a significantly lower total dose of fentanyl required (147.75±122.30 min for Group A, 27.75±53.91 min for Group P) p=0.01. Patient satisfaction (p=<0.01), anesthesia quality (p=0.006), and surgical quality (p=0.047) were significantly higher in Group P.Conclusions: For patients without pain secondary to fractures, the posterior approach to sciatic nerve block is preferable. If patients have pain secondary to fractures, the anterior approach is preferable so as to avoid repositioning.
Daiobotanpito combined with antibiotic therapy for treatment of acute diverticulitis: a study protocol for a randomized controlled trial
Authors: Ogawa-Ochiai Keiko , Yoshimura Keinichi , Shirai Akiko , Sakai Seisho , Moriyama Hideki , Nakamura Keishi , Murayama Toshinori , Ishikawa Hideki 
Published: September 2019

Abstract
Background: Colonic diverticular disease has been increasing in prevalence due to the rapidly aging global population, but standard treatment has not changed dramatically in recent years. Daiobotanpito (DBT; Da Huang Mu Dan Tang in Chinese) has been used in medical treatment of acute abdominal abscesses, such as appendicitis or diverticulitis in traditional Japanese (Kampo) medicine for many years, based on more than 3000 years of experience. Prior to this study, a retrospective open-label trial was conducted to compare patients with acute diverticulitis who received oral DBT combined with intravenous antibiotics with those who received intravenous antibiotic alone; it showed a positive effect of DBT on acute diverticulitis. We aim to investigate whether moderate to severe acute diverticulitis shows greater improvement with intravenous antibiotics plus orally administered DBT compared with intravenous antibiotics with placebo. Methods: This is a two-group, randomized, double-blind, placebo-controlled, multi-center trial, which is designed to evaluate the efficacy and safety of DBT for moderate to severe diverticulitis patients treated with intravenous antibiotics. Eligible participants will be randomized to either a treatment group receiving a 10-day oral DBT regimen plus conventional therapy or a control group receiving a 10-day placebo regimen plus conventional therapy. The primary outcome will be the rate of fever reduction within 3 days or/and abdominal pain relief within 4 days. Secondary endpoints will include hospitalization days, changes in inflammatory response (CRP, WBC, neutrophil count), thermal type, number of days before beginning food intake, recurrence rate (observation for 1 year after registration), and adverse event expression rate. Assessments will be performed at baseline and on the day of discharge. The recurrence rate will be recorded at 1 year after registration. Discussion: This study is expected to provide evidence to support the clinical benefits of DBT in the treatment of acute diverticulitis. It may also provide evidence regarding the efficacy and safety of DBT in the recurrence of acute diverticulitis. Trial registration: UMIN000027381, registered on April 27th, 2017 https://upload.umin.ac.jp/cgi-bin/ctr/ctr_view_reg.cgi?recptno=R000031377, and changed to jRCTs041180063, registered on July 30th, 2019; https://jrct.niph.go.jp/en-latest-detail/jRCTs041180063
Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells
Authors: Shi Danning , ZHAO PIWEN , CUI LIXIA , SUN LIPING , LI HONGBO , NIU JIANZHAO , CHEN MENG 
Published: September 2019

Abstract
Background : Breast cancer is the most frequently diagnosed cancer among women and the second leading cause of cancer death. Especially nuclear estrogen receptor (nER) negative breast cancer is always with much poor prognosis. In recent years, it was reported that membrane G protein coupled estrogen receptor (GPER), a newly recognized estrogen receptor took essential part in the development and treatment of breast cancer, especially nER negative breast cancer. The present study aimed to investigate the anti nER negative breast cancer effect and its possible molecular pathway of cryptotanshinone (CPT), an important active compound of traditional Chinese medicine Danshen.Methods: The following in vitro tests were performed in nER negative but GPER positive breast cancer SKBR-3 cells. The effect of CPT on cell proliferation rate and cell cycle distribution was evaluated by MTT cell viability test and flow cytometry assay. The role of PI3K/AKT pathway and the mediated function of GPER were tested by western blot and immunofluorescence. Technique of gene silence and the specific GPER agonist G-1 and antagonist G-15 were employed in the experiments to further verify the function of GPER in mediating the anticancer role of CPT. Results: The results showed that proliferation of SKBR-3 cells could be blocked by CPT in a time and dose dependent manner. CPT also exerted antiproliferative activities by arresting cell cycle progression in G1 phase and down regulating the expression level of cyclin A, cyclin B, cyclin D and cyclin-dependent kinase 2 (CDK2). The antiproliferative effect of CPT was further enhanced by G1 and attenuated by G15. Results of western blot and immunofluorescence both showed that PI3K and p-AKT protein expression could be down regulated by CPT and such effects were mediated by GPER which is further demonstrated by GPER gene silence test.Conclusion: Our present study shows that the antiproliferative action of CPT on SKBR-3 cells is realized by inhibition of GPER mediated PI3K/AKT pathway. These findings deserve further validation for serving as useful therapeutic targets.