bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Proof of Concept Study Regarding the Utilization of Different Patient-related Outcome Measurements in a Certified Centre of Excellence for Joint Replacement (EndoProthetikZentrum)
Authors: Osmanski-Zenk Katrin , Oskina Anastasia , Bader Rainer , Mittelmeier Wolfram 
Published: June 2019

Abstract
Background The aim of the study is to identify those patients without improved pain sensation and functionality of the joint, thus with a potential necessity of re-intervention by using the evaluation of the PROMs (Oxford Hip Score, European Quality of Life Scale, EndoCert-Risk-Score). The task was to determine the value of the scores which represents the limit above/below, which a re-examination of the patient is necessary. Additionally, further secondary objectives such as influence of complications on scores, the percentage of questionnaire return and the quality of the provided data in the questionnaires were recorded to define minimal requirements on patientʼs response.
Material and Methods Members of the EndoCert certification committee developed a questionnaire for pre- (decision on treatment) and post-operative (discharge and 3-months follow-up) use. A total of 112 primary hip replacements and 25 hip revision arthroplasties, which were recruited from a centre of excellence for joint replacement (EndoProthetikZentrum der Maximalversorgung), were included in the study.
Results The return of questionnaires amounted to 80%. Quality of data in the questionnaires declined with BMI (≥ 25), ASA classification (≥ 3), age (≥ 65) and depended on the time point questioning. Based on the EndoCert risk score there was a significant improvement in the experience of pain postoperatively compared to pre-operation (p < 0.05). However, the functionality of the joint, as measured as the use of walking frames or crutches as well as the need for help from others, did not improve. The results revealed that there was no correlation between the incidence of complications and a detrimental score. It was furthermore shown that patient specific attributes, e.g. age or BMI, or perioperative performance (duration of operation) did not influence the likelihood of a complication.
Conclusion It was shown that Oxford Hip Score and EQ-5D were not negatively influenced by complication during hospital stay. The evaluation of the EndoCert risk score showed not improvement between pre- and post-operative values regarding function but revealed a significant pain relief. A further study is intended to evaluate the intensity of pain after three months as part of an extended systemic follow-up. This could provide further insights whether the EndoCert risk score is a suitable tool to identify unsuccessfully treated patients.
Verbessert die Diagnostik des unteren Uterinsegments die Geburtsplanung bei Status nach Sectio?
Authors: Schmitz Jessica , Stepan Holger , Schrey-Petersen Susanne , Hoffmann Janine 
Published: June 2019

Zusammenfassung
Einleitung Bei Patientinnen mit Status nach Sectio ist die sonografische Diagnostik des unteren Uterinsegments (uUS) weit verbreitet. Ihr Nutzen für die Geburtsplanung ist jedoch nicht ausreichend belegt. Es gibt weder ein einheitliches Untersuchungsprotokoll noch einen sicheren Cut-off-Wert. Ziel dieser Studie war es, den Wert der uUS-Diagnostik in der klinischen Routine zu prüfen.
Material und Methoden In die retrospektive Analyse wurden 631 Patientinnen mit Status nach Sectio eingeschlossen. Bei 399 (63%) Patientinnen war eine sonografische Dickenmessung des Myometriums (muUS) und/oder des gesamten uUS (guUS)) erfolgt. Die Inzidenz von Uterusdefekten sowie der Zeitpunkt und die Modalität ihrer Diagnostik wurden eruiert. Sensitivitäten, Spezifitäten, positive (PPV) und negative prädiktive Werte (NPV) wurden für verschiedene Cut-offs errechnet.
Ergebnisse Uterusdefekte traten bei 28 (4,4%) Patientinnen auf. Die Detektionsrate für die Sonografie war gering (13,6%), die Sensitivität/ Spezifität/ PPV/ NPV für niedrigere Cut-off-Werte (2 mm (guUS)/ 1 mm (muUS): 75/96/48,3/98,7%) jedoch besser als für höhere (3 mm (guUS)/ 2 mm (muUS): 15,8/93,2/10,4/68,7%).
Diskussion Der Nutzen der sonografischen uUS-Diagnostik erscheint überschätzt. Da ihre Genauigkeit von zahlreichen methodischen Faktoren beeinflusst wird, könnte sie durch ein einheitliches Protokoll mit einem transabdominellen und transvaginalen Scan durch einen erfahrenen Untersucher verbessert werden. Ein geeigneteres Untersuchungsziel für die Selektion nach Sectio könnte der Ausschluss von Uterusdefekten sein.
Interventionen zur Resilienzförderung bei
Erwachsenen
Authors: Linz Svenja , Helmreich Isabella , Kunzler Angela , Chmitorz Andrea , Lieb Klaus , Kubiak Thomas 
Published: June 2019

ZusammenfassungResilienz bezeichnet die Aufrechterhaltung bzw. rasche Wiederherstellung der
psychischen Gesundheit während oder nach stressvollen
Lebensumständen. Aktuelle Forschungsergebnisse legen nahe, dass
Resilienz dynamisch ist und trainiert werden kann. Obwohl Interventionen zur
Stärkung der Resilienz häufig zur
Gesundheitsförderung bei verschiedenen Zielgruppen eingesetzt
werden, ist deren Effektivität jedoch kaum systematisch untersucht.
Diese Übersichtsarbeit beurteilt narrativ die Ergebnisse 4
systematischer Reviews und Metaanalysen zu Resilienzinterventionen bei
Erwachsenen und fasst die Evidenz aus den randomisiert-kontrollierten
Primärstudien (N=44) zusammen. Insgesamt erzielten die
Resilienzinterventionen kleine bis moderate Effekte bzgl. der Steigerung von
Resilienz und der Verbesserung der psychischen Gesundheit. Trotz
methodischer Schwächen scheinen Resilienzinterventionen wirksam zu
sein und könnten somit eine gute Ergänzung zu aktuellen
Präventionsmaßnahmen darstellen.
Facettenreiche Symptomatik mit Gelenkschmerzen, Exanthem und Augenbeteiligung
Authors: Tsiami Styliani , Regel Andrea , Baraliakos Xenofon , Braun Jürgen , Kiltz Uta 
Published: June 2019

Zusammenfassung
Anamnese und klinischer Befund In dieser Fallserie stellen wir 4 Patienten vor, die mit unterschiedlichen Symptomen in unserer rheumatologischen Spezialklinik vorgestellt wurden und die letztlich dieselbe Erkrankung hatten. Zu dem breiten Spektrum der vorliegenden Symptome gehörten neben Arthralgien und Myalgien auch ein makulopapulöses Exanthem und eine Sehstörung. Ein Patient wurde wegen aktiver ankylosierender Spondylitis und rezidivierender Uveitis mit einem TNF-Blocker behandelt. In der klinischen Untersuchung wurden Gelenkschwellungen und Hautveränderungen festgestellt.
Untersuchungen Serologisch wurden bei allen Patienten ein erhöhter TTPA- sowie ein positiver RPR-Test festgestellt.
Diagnose Bei den Patienten wurde Syphilis diagnostiziert.
Therapie und Verlauf Die ersten 3 Patienten erhielten eine einmalige intramuskuläre Injektion mit 2,4 Mil. Benzathinpenicillin G. Der 4. Patient wurde mit Penicillin 6 Mio 4/d i. v. über 14 Tage aufgrund seiner bestehenden Immunsuppression behandelt.
Folgerung Bei Vorliegen unspezifischer und zum Teil diffuser Symptome, mit welchen sich Patienten in der Rheumatologie häufig stellen, kann ätiopathogenetisch auch eine nicht primär rheumatologische, z. B. infektiöse Genese vorliegen. Die in den letzten Jahren in Deutschland wieder zunehmende Inzidenz der Syphilis ist auch in der rheumatologischen Versorgung zu beachten.
Wie bewerten Mitarbeiter einer psychiatrischen Klinik medizinethische Konflikte bei Zwangsmaßnahmen
Authors: Schwerthöffer Dirk , Seidl Otmar , Hamann Johannes 
Published: June 2019

Zusammenfassung
Hintergrund Die Praxis von Zwangsmaßnahmen in psychiatrischen Kliniken wirft eine Reihe von medizinischen, juristischen und ethischen Fragen auf. Unter anderem führen Zwangsmaßnahmen zu Konflikten zwischen verschiedenen medizinethischen Prinzipien. Im Rahmen einer Pilotstudie sollte abgebildet werden, wie in der Psychiatrie Beschäftigte verschiedene medizinethische Prinzipien gegeneinander abwägen und wie sie für einen hypothetischen Fall zu einer Entscheidung für oder gegen den Einsatz von Zwangsmaßnahmen kommen.
Methode Alle therapeutisch tätigen Mitarbeiter verschiedener Berufsgruppen einer psychiatrischen Klinik wurden in einem Fragebogen zu ihrer Einstellung zu medizinethischen Prinzipienkonflikten und im Rahmen einer Kasuistik zu einer Entscheidung für oder gegen Zwangsmaßnahmen bei einem schizophren erkrankten Patienten befragt.
Ergebnisse Die Rücklaufquote des Fragebogens betrug 71 % (73 Teilnehmer). Die Mehrheit der Befragten war der Meinung, dass bei medizinethischen Prinzipienkonflikten der Schwerpunkt einer psychiatrischen Behandlung auf dem Wohl des Patienten (89 %) gegenüber dem Gemeinwohl liegen sollte. Das Autonomieprinzip wurde etwas häufiger über das Fürsorgeprinzip gestellt (58 % vs. 42 %) und die „Nonmalefizienz“ (Schadensvermeidung) erschien den Befragten in etwa gleich bedeutend wie die „Benefizienz“ (51 % vs. 49 %). Bei der Kasuistik wurden weniger „invasive“ Zwangsmaßnahmen (z. B. gesetzliche Betreuung) invasiveren (z. B. Zwangsmedikation) vorgezogen. In dieser Stichprobe zeigten sich keine statistisch hochsignifikanten Zusammenhänge zwischen soziodemographischen Faktoren (auch Berufserfahrung und Berufsgruppenzugehörigkeit), Gewichtung von medizinethischen Prinzipien und der Bewertung von Zwangsmaßnahmen. Tendenziell schienen aber Mitarbeiter von beschützten Stationen, mit mittlerer Berufserfahrung (6-15 Jahre) und Mitarbeiter der Pflegeberufe Zwangsmaßnahmen etwas häufiger zu befürworten. Ein Zusammenhang zwischen der Gewichtung medizinethischer Prinzipien und einer Befürwortung oder Ablehnung von Zwangsmaßnahmen in der Kasuistik war nicht zu beobachten.
Schlussfolgerung Zwangsmaßnahmen führen zu medizinethischen Konflikten. Der Einfluss dieser Konflikte auf die Anwendung von Zwangsmaßnahmen durch Mitarbeiter psychiatrischer Kliniken wird deshalb im Rahmen einer qualitativen Folgestudie, die auf den Ergebnissen dieser Untersuchung basiert, differenzierter untersucht werden.
Perioperative and oncologic outcome in patients treated for renal cell carcinoma with an extended inferior vena cava tumour thrombus level II-IV
Authors: Adams Lisa , Ralla Bernhard , Maxeiner Andreas , Mang Josef , Krimphove Michael , Dushe Simon , Makowski Marcus , Miller Kurt , Fuller Florian , Busch Jonas 
Published: June 2019

Abstract
Purpose Surgical treatment of patients with renal cell carcinoma (RCC) and an extended tumour thrombus (TT) in the inferior vena cava (IVC) is challenging and often requires a multidisciplinary approach. The aim of this study was to analyse results in the real-world management of RCC patients with an extended IVC TT (level II-IV according to the Mayo classification of macroscopic venous invasion in RCC) in terms of pre-, peri- and postoperative outcome, complications and oncologic outcome.
Methods We investigated 61 patients with evidence of RCC and an extended TT in the IVC undergoing radical nephrectomy and tumour thrombectomy at our tertiary referral centre. Patients and operative characteristics were recorded and complications were analysed using the Clavien-Dindo classification. Follow-up data were retrieved by contacting the treating outpatient urologists, general practitioners and patients.
Results The TT level was II in 36, III in 8 and IV in 17 patients. Complications grade IIIb and higher according to the Clavien-Dindo classification occurred in n = 3 (8.4 %), n = 2 (25.0 %) and n = 5 (29.5 %) patients with level II, III and IV TT, respectively. The overall survival of patients with TT level II, III and IV at 24 months (60 months) was 66.9 % (41.6 %), 83.3 % (83.3 %) and 64.1 % (51.3 %). Presence of primary metastatic disease was the only significant independent predictor for OS.
Conclusions Radical nephrectomy with tumour thrombectomy appears to be a feasible and effective treatment option in the management of patients with RCC and an extended IVC TT.
Guaianolides from Ormenis mixta: Structural Insights and Evaluation of Their Anti-inflammatory Profile
Authors: Benteldjoune Mounira , Chini Maria Giovanna , Iannuzzi Anna Maria , Kabouche Ahmed , Kabouche Zahia , DʼAmbola Massimiliano , Marzocco Stefania , Autore Giuseppina , Bifulco Giuseppe , De Tommasi Nunziatina 
Published: June 2019

AbstractIn this paper, the isolation of five new guaianolides (1 – 5) and four (6 – 9) known sesquiterpenes from Ormenis mixta aerial parts is reported. The structural determination of the guaianolides was obtained by NMR spectroscopic data, as well as MS experiments. Their relative configurations were assigned by a combined quantum mechanical/NMR approach, comparing the experimental 13C/1H NMR chemical shift data and 1
J
H-H homonuclear coupling constants with the related predicted values. The isolates were assayed for their anti-inflammatory potential evaluating nitric oxide release and cyclooxygenase-2 expression in J774A.1 macrophages treated with lipopolysaccharide from Escherichia coli. Our results indicated that, among the tested compounds, 1 – 3, and 7 were able to inhibit nitric oxide release, while all were able to inhibit cyclooxygenase-2 expression with different potencies.
Hip Inflammatory Conditions: A Practical Differential Diagnosis Algorithmic Approach in Adults and Children
Authors: Jaremko Jacob L. , Teh James , Weidekamm Claudia , Jans Lennart , Herregods Nele 
Published: June 2019

AbstractThe child or adult patient presenting with acute hip pain in the absence of major trauma often presents a difficult diagnostic dilemma, due to the complex anatomy and diversity of pathology at the hip. A correct diagnosis is important because untreated hip inflammatory disease can lead to lifelong morbidity from structural damage at this weightbearing joint. An effective and efficient process of reaching an appropriate diagnosis often requires multiple imaging modalities overseen by careful clinical judgment. This article reviews an algorithmic approach to imaging the acutely painful hip, with attention to uses and limitations of each imaging modality, and it offers details on the key differential diagnoses in adults and children.
Imaging Methodology for Hip Preservation: Techniques, Parameters, and Thresholds
Authors: Mascarenhas Vasco V. , Ayeni Olufemi R. , Egund Niels , Jurik Anne G. , Caetano António , Castro Miguel , Novo João , Gonçalves Sara , Sutter Reto 
Published: June 2019

The concept of hip impingement and hip-preserving surgery has been appreciated in more detail since 2001 when a new surgical approach was reported and a hypothesis linking femoroacetabular impingement (FAI) with osteoarthritis was presented. Paralleling the introduction of hip arthroscopy, these events led to an increasing interest in the hip, and the number of publications has risen rapidly over the past 15 years, despite limited evidence levels and inconsistent methodology. Accordingly, etiology, diagnosis, prognosis, and the effects of treatment for FAI are still elusive due to a number of uncertainties and a lack of clear diagnostic criteria.Future research must focus on developing high-quality scientific studies, so thorough and reproducible methodology is needed. This review provides researchers, radiologists, and clinicians with a comprehensive approach to hip imaging with a focus on strategies to help guide the clinical diagnosis. Using evidence from current literature and knowledge from experienced clinicians, some of the imaging methodology challenges are deciphered.
Persistent Fetal Trigeminal Artery with Septopreoptic Holoprosencephaly: Report of an Unusual Association
Authors: D. Sunilkumar , M. Kiran , A. Subathra , K. Nagarajan 
Published: June 2019

AbstractSeptopreoptic holoprosencephaly (HPE) is a type of HPE characterized by failure of separation of the septal and preoptic regions. Vascular anomalies associated with septopreoptic HPE include twig-like cerebral vessels and azygos anterior cerebral artery, the latter common to all forms of HPE. Here, we describe an 8-year-old boy presenting with developmental delay and abnormal movements who was found to have septopreoptic HPE associated with persistent trigeminal artery in magnetic resonance neuroimaging. This persistence of fetal trigeminal artery in HPE provides a further understanding of the pathogenesis of HPE.
A Novel CLCN5 Splice Site Mutation in a Boy with Incomplete Phenotype of Dent Disease
Authors: Bitsori Maria , Vergadi Eleni , Galanakis Emmanouil 
Published: June 2019

AbstractDent disease is a rare X-linked renal proximal tubulopathy presenting with low-molecular-weight proteinuria (LMWP), hypercalciuria, and nephrocalcinosis, other signs of incomplete renal Fanconi syndrome, and renal failure. Early identification of patients who harbor disease-associated mutations is important for effective medical care and avoidance of unnecessary interventions. We report the case of an asymptomatic 9-year-old boy who presented with proteinuria in routine examination. Further investigation revealed the presence of nephrotic range proteinuria, mostly LMWP and mild hypercalciuria without nephrocalcinosis, or other features of tubular dysfunction. Renal function, growth, and bone mineral density were within regular limits. The male gender and the presence of LMWP and hypercalciuria even in the absence of other findings prompted us to genetic investigation for Dent disease. A novel splice site mutation (c.416–2A > G) of the chloride voltage-gated channel 5 (CLCN5) gene, responsible for Dent disease type 1 was identified. In silico analysis revealed that this mutation interferes with the mating of exons 4 and 5. Due to early molecular diagnosis, our patient did not undergo a renal biopsy, neither required aggressive pharmacological interventions. This case underscores the diversity and complexity of CLCN5 mutations and highlights the importance of early molecular testing in male patients with incomplete phenotype of Dent disease.
Social transmission favours the ‘morally good’ over the ‘merely arousing’
Authors: Stubbersfield Joseph M. , Dean Lewis G. , Sheikh Sana , Laland Kevin N. , Cross Catharine P. 
Published: June 2019

AbstractMoral stories are pervasive in human culture, forming the basis of religious texts, folklore, and newspaper articles. We used a linear transmission chain procedure to test three competing hypotheses: (1) that moral content in general is preferentially transmitted between individuals compared to non-moral content; (2) that negativity bias leads specifically to morally bad content being preferentially transmitted; and (3) that a bias towards pro-social information leads specifically to morally good content being preferentially transmitted. While we found no support for a bias for moral content in general, we did find that morally good content was transmitted with greater fidelity than neutral or morally bad content, with ratings of morally good content but not morally bad content predicting transmission. Moral content, therefore, appears to be particularly culturally potent when it describes the ‘virtuous’ rather than the ‘sinful’. A second study repeated the first but also tested the influence of physiological arousal on transmission by measuring the electrodermal activity of participants. This study also found that morally good content was transmitted with greater fidelity than neutral or morally bad content and that physiological arousal had a negative effect on transmission with more arousing material being less faithfully transmitted. These results suggest that the communication of content relating to moral virtue might serve to avoid negative impression formation and promote social bonding, and that this might partially explain the ubiquity of moral content in human culture.
NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models
Authors: Bahn Gahee , Park Jong-Sung , Yun Ui Jeong , Lee Yoon Jee , Choi Yuri , Park Jin Su , Baek Seung Hyun , Choi Bo Youn , Cho Yoon Suk , Kim Hark Kyun , Han Jihoon , Sul Jae Hoon , Baik Sang-Ha , Lim Jinhwan , Wakabayashi Nobunao , Bae Soo Han , Han Jeung-Whan , Arumugam Thiruma V. , Mattson Mark P. , Jo Dong-Gyu 
Published: June 2019

SignificanceConsidering that Alzheimer’s disease (AD) is a chronic disease progressing over a long period of time, even a slight increase ofBACE1expression may have a profound effect on Aβ accumulation. We describe a previously unknown mechanism that negatively regulatesBACE1andBACE1-ASexpression and demonstrate its pivotal role in the progression of Aβ and Tau pathologies and cognitive impairment in two mouse models of AD. Given the recent failures of the clinical trials using enzymatic inhibitors of BACE1, it is critical to explore alternative approaches such as down-regulatingBACE1andBACE1-AStranscription. Our finding that NRF2 negatively regulates BACE1 and BACE1-AS therefore suggests a potential for disease modification by NRF2-activating phytochemicals or synthetic small molecules in AD.
Reconstructing sexual divisions of labor from fingerprints on Ancestral Puebloan pottery
Authors: Kantner John , McKinney David , Pierson Michele , Wester Shaza 
Published: June 2019

SignificanceThe evolution of the sexual division of labor within human societies is difficult to reconstruct because of the scarcity of direct evidence recovered from archaeological contexts, and yet many disciplines make assumptions regarding how labor first became specialized in our species. We propose an innovative method for identifying the sex of potters through the analysis of fingerprint impressions recovered from material culture. An application of the method to ancient pottery demonstrates that males and females were both significantly involved in producing vessels. The study further suggests that the exact proportion of each sex involved in pottery making was quite fluid, and may have varied among different groups in the same community, as well as changed from generation to generation.
Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment
Authors: Gan Kathlyn J. , Südhof Thomas C. 
Published: June 2019

Significance
Cognitive function decreases during aging, but the mechanisms involved remain unclear. Revolutionary recent studies revealed that introduction of blood from young mice into old mice increased cognitive abilities and synaptic connectivity, suggesting that young blood contains specific factors supporting cognitive function. Here, we asked whether young blood is enriched in factors that act directly on neurons to promote synapse formation. We show that serum from young but not old mice indeed directly boosts synapse formation in cultured neurons, and identify two factors, thrombospondin-4 and SPARCL1, that are enriched in young blood and mediate these effects. Thus, our experiments show that young blood is enriched in multiple factors that directly promote synaptic connectivity between neurons.
A new in vitro muscle contraction model and its application for analysis of mTORC1 signaling in combination with contraction and beta-hydroxy-beta-methylbutyrate administration
Authors: Sato Satoko , Nomura Mitsuru , Yamana Ikko , Uchiyama Akira , Furuichi Yasuro , Manabe Yasuko , Fujii Nobuharu L 
Published: June 2019

ABSTRACT
Several food constituents augment exercise-induced muscle strength improvement; however, the detailed mechanism underlying these combined effects is unknown because of the lack of a cultured cell model for evaluating the contraction-induced muscle protein synthesis level. Here, we aimed to establish a new in vitro muscle contraction model for analyzing the activation of mammalian target of rapamycin complex 1 (mTORC1) signaling. We adopted the tetanic electric stimulation of 50 V at 100 Hz for 10 min in L6.C11 myotubes. Akt, ERK1/2, and p70S6K phosphorylation increased significantly after electrical pulse stimulation (EPS), compared to untreated cells. Next, we used this model to analyze mTORC1 signaling in combination with exercise and beta-hydroxy-beta-methylbutyrate (HMB), an l-leucine metabolite. p70S6K phosphorylation increased significantly in the EPS+HMB group compared to that in the EPS-alone group. These findings show that our model could be used to analyze mTORC1 signaling and that HMB enhances muscle contraction-activated mTORC1 signaling.