bluuebunny/crossref_metadata_2025_split huggingface dataset:
The positive significance of staged physical mental combined pain reduction nursing based on pain scoring for cancer pain patient
Authors: Shao Xiaoqian , Sun Xuan , Chen Qiuyang , Shi Lingyun , Wang Yeping , Lv Xueqin 
Published: November 2024

AbstractTo observe the positive of stage‐based physical mental combined pain reduction nursing based on pain scoring for cancer pain patients. A total of 120 cancer pain patients admitted to our hospital from December 2022 to December 2023 were selected. They were randomly divided into a control group and an observation group, with 60 cases in each group. The control group received medication intervention nursing, whereas the observation group received phased physical mental combined pain reduction nursing. The visual analogue scale (VAS) pain scores, Psychological Hope Level (HHI) score and Psychological Health Mood State Questionnaire (POMS) score of the two groups of patients were observed before nursing and at 1, 6, and 12 months after nursing. There was no difference in VAS scores between two groups at 1 month after nursing care (p > 0.05), but the observation group had lower VAS scores at 1, 6, and 12 months after nursing; In the HHI score of the observation group patients after nursing, there was no difference between the pre‐nursing and 1 month post nursing scores and the control group (p > 0.05), but scores were lower than the control group at 6 and 12 months after nursing; The POMS score of the observation group patients after nursing was better than the control group. All the difference was statistically significant (p < 0.05). Our findings suggest that staged physical mental combined pain reducing care has a positive impact on patients with cancer pain.
Unlocking Single‐Particle Multiparametric Sensing: Decoupling Temperature and Viscosity Readouts through Upconverting Polarized Spectroscopy
Authors: Ortiz‐Rivero Elisa , Prorok Katarzyna , Marin Riccardo , Bednarkiewicz Artur , Jaque Daniel , Haro‐González Patricia 
Published: November 2024

AbstractUpconverting particles (UCPs), renowned for their capability to convert infrared to visible light, serve as invaluable imaging probes. Furthermore, their responsiveness to diverse external stimuli holds promise for leveraging UCPs as remote multiparametric sensors, capable of characterizing medium properties in a single assessment. However, the utility of UCPs in multiparametric sensing is impeded by crosstalk, wherein distinct external stimuli induce identical alterations in UCP luminescence, hindering accurate interpretation, and yielding erroneous outputs. Overcoming crosstalk requires alternative strategies in upconverting luminescence analysis. In this study, it is shown how a single spinning NaYF4:Er3+, Yb3+ upconverting particle enables simultaneous and independent readings of temperature and viscosity. This is achieved by decoupling thermal and rehological measurements—employing the luminescence of thermally‐coupled energy levels of Er3+ ions for thermal sensing, while leveraging the polarization of luminescence from non‐thermally coupled levels of Er3+ ions to determine viscosity. Through simple proof‐of‐concept experiments, the study validates the capability of a single spinning UCP to perform unbiased, simultaneous temperature, and viscosity sensing, thereby opening new avenues for advanced sensing in microenvironments.
Preparation, Structural Characterization, and Biological Activity of Selenated Potato Resistant Starch
Authors: Huang Xiufang , Dou Lei , Xiong Kun , Zhang Shiyi , He Huahan , Wang Shanshan , Luo Kai , Hu Dongqiang 
Published: November 2024

AbstractThis study develops selenized potato resistant starch (P‐RS4·Se) from Enshi potato starch to enhance bioactivity. First, the resistant starch (P‐RS4) is prepared through high‐temperature citric acid esterification. Then, P‐RS4 is selenized using the nitrate‐sodium selenite method and analyzed with Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X‐ray Photoelectron Spectroscopy (XPS), and Nuclear Magnetic Resonance (NMR). Optimal conditions are identified: 0.7 % HNO3, a 1:1.1 ratio of P‐RS4 to Na2SeO3, 65 °C, and 4 h. Selenization disrupts P‐RS4·Se’s microstructure, forming a Se─O─C bond with ─OH on C6. The selenized starch shows strong in vitro antioxidant effects, protecting A549 lung cancer cells from oxidative damage at 6–8 mg mL−1, supporting selenium supplementation.
Contribution to the design of prestressed hollow core purlins without transverse reinforcement
Authors: Carvalho Geovana Izabel de Macedo , Ferreira Marcelo de Araujo , Catoia Bruna 
Published: November 2024

AbstractThe hollow core purlin is a structural element resulting from the sectioning of hollow core slabs into two ribs. This component can be classified as a prestressed hollow core beam without transverse reinforcement. Although this solution offers potential for increasing the productivity of precast concrete element factories, it currently lacks normative guidelines due to the high risk of shear failure. The aim of this study is to highlight an equation to underpin the design of hollow core purlins based on experimental verification. To achieve this objective, six samples of hollow core purlins were analyzed. Initially, the manufacturing characteristics and cross‐sectional geometry of each piece were observed to gather data on the production process. Subsequently, positive bending tests were conducted to characterize stiffness and determine the effective mean tensile strength. Later, shear strength tests were performed to identify the failure mechanisms of the elements. In parallel, the prestressing forces, stiffness, tensile strength, cracking moment, calculated shear strength using the flexural‐shear mechanism, and verification of shear strength due to diagonal tension were computed based on concrete compressive strength values and data provided by the manufacturer. Finally, the experimental values obtained were compared with the theoretical calculated values to establish a correlation that highlights the calculation procedure that best represents the behavior of the studied elements.
Bovine tuberculosis trends in Wales between 2010 and 2021
Authors: Seery Sarah , Schroeder Paul , Galloway Terry , Abernethy Darrell , Hewinson Glyn 
Published: November 2024

AbstractBackgroundBovine tuberculosis (bTB) is the most important animal health concern in Wales. Annual testing across all cattle herds in Wales commenced in 2010. In 2017, a new geographic division of Wales was conceived, with bespoke cattle controls and eradication milestones reflecting the geographical heterogeneity of bTB distribution.MethodsThis observational study uses descriptive analysis and Poisson regression modelling to analyse bTB surveillance data from all herds in Wales.ResultsSince 2010, there has been a significant decrease (p < 0.0001) in bTB incidence (8.6%‒6.3%) and plateauing prevalence across Wales. Conversely, there has been an increase in bTB incidence and prevalence in discrete areas. Recurrence and persistence remain important drivers of bTB infection. One of the sharpest declines in bTB incidence was observed in an intensive action area where enhanced cattle control and wildlife vaccination were implemented in an area of high bTB prevalence. Increased herd size, dairy herd type and herd location are important risk factors affecting the rate of bTB incidents in Wales.LimitationsThis study includes data from Wales only.ConclusionsImprovements in trends of bTB occurred from 2010 to 2021, but the spatial variations described in this paper support the continued need for regionally adapted surveillance and control measures.
European brown hare syndrome virus and other lagoviruses of interest
Authors: Duff Paul , Everest David , Martindale Lucy , Barlow Alex , Rocchi Mara , Lavazza Antonio 
Published: November 2024

AbstractThis focus article was prepared by Paul Duff of the APHA Wildlife Expert Group, with support from David Everest (APHA Pathology Department), Lucy Martindale (APHA Surveillance Intelligence Unit), Alex Barlow (Wildlife Network for Disease Surveillance), Mara Rocchi (Moredun Research Institute) and Antonio Lavazza (Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Italy).
Chemically reactive stagnated third‐grade magnetized nanomaterial considering modern diffusion approaches
Authors: Kausar Muhammad Salman , Nasir Muhammad , Waqas Muhammad , Almohammadi Saja Mohammad , Zamri Nurnadiah 
Published: November 2024

AbstractAn incompressible boundary‐layer third‐grade nanomaterial stagnated flow confined by stretchy regime is formulated. The laminar magnetized thermal and solutal flow features the aspects of Brownian diffusion, generalized thermal‐flux, thermophoresis, and generalized solutal‐flux. The dimensionalized third‐grade steady‐state model is obtained by implementing appropriate variables. The subsequent nonlinear mathematical model is analytically computed by utilizing homotopy algorithm. The graphics demonstration of nondimensional fields (i.e., velocity, concentration, and temperature) for distinct physical variables is exhibited. The outcomes for the skin‐friction coefficient are calculated and confirmed to be precise. The analysis reveals that augmented values of material parameters escalate nanomaterial velocity while the Hartman number exhibits lower velocity. The temperature field displays a decaying trend for Prandtl number and thermal relaxation variable while contrary effects for nanoscale parameters (i.e., thermophoresis diffusive and Brownian diffusive) are reported. Besides, the nanomaterial concentration shows a decreasing trend with respect to the Schmidt number, Brownian motion, and solutal‐relaxation variable while thermophoresis parameter exhibits opposite effects. Furthermore, this study could be valuable for the design of various lab‐on‐a‐chip and thermal microfluidic devices in the field of biomedicine. Besides contributing to the creation of new devices, they may also be advantageous for performing genetic testing and developing innovative tools.
Imagining a New Gender Contract for Democracy
Authors: Sénac Réjane 
Published: November 2024

AbstractWhat challenges must be overcome to achieve parity democracy in twenty-first century Europe? In view of the political participation crisis, most visible in the disaffection of citizens with elections and their mistrust of elected representatives, coupled with the rise of populism, Europe has a role to play in reviving the political debate, particularly in the defence and enforcement of fundamental rights. To address these issues, we analyse how Europe can participate in the advent of a more egalitarian democracy, in keeping with its role in redefining democracy through the lens of parity. We then examine the current challenges that need to be overcome to address this issue from two angles: the connection between descriptive and substantive representation, and the overlap between inequalities and demands from an intersectional perspective.
Characterisation of autophagy induction by the thiopurine drugs azathioprine, mercaptopurine and thioguanine in THP-1 macrophages
Authors: Masson Connan D. , Findlay-Greene Fern , Sousa Filipa Henderson , Henderson Paul , Fraser Jennifer A. , Barlow Peter G. , Stevens Craig 
Published: November 2024

AbstractActivating autophagy may be therapeutically beneficial, and we have previously shown that azathioprine (AZA), an immunomodulatory drug, induces autophagy. Here, we evaluated the induction of autophagy by the thiopurines AZA, mercaptopurine (6-MP) and thioguanine (6-TG) in THP-1 macrophages and investigated the mechanism of action in the context of this cellular process. The cytotoxicity of thiopurines was evaluated using an LDH assay. Induction of endogenous LC3 by thiopurines was evaluated using immunostaining. To confirm autophagy activation by thiopurines, a GFP-RFP-LC3 reporter plasmid was used to monitor the maturation of autophagosomes to autolysosomes. Induction of apoptosis by thiopurines was evaluated using Annexin V/PI staining, and ER stress was assessed via RT‒PCR analysis of XBP1 splicing. To gain insight into the mechanism of action of thiopurines, mTORC1 activity and eIF2α-S51 phosphorylation were evaluated by immunoblotting. Thiopurines were not cytotoxic to cells and induced strong time- and concentration-dependent autophagy. Thiopurines activate autophagy with complete progression through the pathway. Induction of autophagy by thiopurines occurred independently of apoptosis and ER stress. Immunoblotting revealed that AZA inhibited mTORC1 activity, and AZA and 6-TG increased eIF2α-S51 phosphorylation. In contrast, 6-MP had a minor effect on either signalling pathway. Thiopurines are strong inducers of autophagy, and autophagy induction should be considered among the mechanisms responsible for patient response to thiopurines.
Prophylactic red blood cell transfusions in children and neonates with cancer: An evidence-based clinical practice guideline
Authors: Kruimer Demi M. , Stavleu Debbie C. , Mulder Renée L. , Kremer Leontien C. M. , Tissing Wim J. E. , Loeffen Erik A. H. ,   On behalf of the prophylactic red blood cell transfusion guideline panel, Bresters Dorine , Evers Janneke H. P. , van Gestel Sjef P. J. , Hagleitner Melanie M. , Heitink-Pollé Katja M. J. , Huisman Elise J. , Janssens Geert O. R. , Kuijper Philip H. M. , Mensink Maarten O. , Nijman Joppe , Noordzij Jeroen G. , Ophorst Ida , Plieger Willemijn , Spijkerman Judith , van der Steeg Alida F. W. , van de Wetering Marianne D. 
Published: November 2024

Abstract
Background
Red blood cell (RBC) transfusions play an important role in supportive care in children and neonates with cancer. However, in current clinical practice, evidence-based recommendations are lacking on when to administer prophylactic RBC transfusions. To address this gap, a clinical practice guideline (CPG) was developed to systematically review the available evidence and provide recommendations for clinicians.

Methods
A systematic literature review in three databases was conducted. The GRADE methodology was used to assess, extract, and summarize the evidence. A multidisciplinary panel of 21 professionals was assembled to ensure comprehensive expertise. If there was insufficient evidence in children with cancer, additional evidence was gathered in general pediatric or adult oncology guidelines, or the panel utilized shared expert opinion to develop a comprehensive CPG. Multiple in-person meetings were conducted to discuss evidence, complete evidence-to-decision frameworks, and formulate recommendations.

Results
Four studies including 203 children with all types of cancer, met the inclusion criteria. The expert panel assessed all evidence and translated it into recommendations. In total, 47 recommendations were formulated regarding RBC transfusions in children and neonates with cancer. For instance, specific thresholds for prophylactic RBC transfusions were recommended for children and neonates with cancer who have sepsis, are on ECMO, or are undergoing radiotherapy.

Conclusion
This clinical practice guideline presents evidence-based recommendations regarding RBC transfusions in children and neonates with cancer. By providing these recommendations, we aim to guide clinicians and contribute to improving outcomes for children and neonates with cancer.
Environmental drivers of mean weight-at-age variability in pelagic and benthic fish from the NW Iberian Peninsula
Authors: Domínguez-Petit Rosario , Cousido-Rocha Marta , Pennino Maria Grazia , Abad Esther , Riveiro Isabel , Costas Gersom , Cerviño Santiago 
Published: November 2024

Abstract
The mean weight-at-age of fish species is an indicator of fish growth and physiological condition, as well as a basic parameter for assessing and managing fish stocks. Here, we investigate the temporal trends of the mean weight-at-age of four different commercial species with different life strategies: (i) the short-lived pelagic European sardine (Sardina pilchardus), (ii) the horse mackerel (Trachurus trachurus) and two medium-lived benthic, (iii) the megrim (Lepidorhombus whiffiagonis) and iv) the four-spotted megrim (Lepidorhombus boscii), in North Atlantic Iberian waters from 2000 to 2018. Generalised additive models were implemented to identify the main (density-dependent and density-independent) drivers of fish weight-at-age variability: abundance, sex, maturity, sea surface temperature, sea bottom temperature, North Atlantic Oscillation (NAO) and Atlantic Multidecadal Oscillation indices. In all four species, abundance had a negative effect on mean weight-at-age. Temperature affected mean weight-at-age in sardine and megrim, while NAO influenced it in horse mackerel and four-spotted megrim. In the case of the sardine, we observed a progressive decrease in the mean weight-at-age of adults in the series in contrast to the four-spotted megrim; however, there was no effect of year on either horse mackerel or megrim. We discuss the influence of life strategy on fish response to drivers.
How altruistic alternatives reverse the compromise effect
Authors: Griesoph Amelie , Schreiner Thomas F. , Melnyk Valentyna , Jänichen Holger D. 
Published: November 2024

AbstractBrand managers increasingly add altruistic product attributes, such as fair trade or charitable donations, to their products to account for consumers’ increasing expectations of altruistic brand behavior. Despite the extensive amount of altruistic product attributes in today’s markets, it is unclear how these attributes affect consumer decision-making in different contexts. This paper particularly examines the influence of altruistic product attributes on the compromise effect. Through five experimental studies, we provide pioneering evidence that consumers face general difficulty in accepting trade-offs involving altruistic attributes and that altruistic attributes change the compromise effect substantially. While the well-established compromise effect, predicting a preference for middle options (compromises) over extreme options, holds for trade-offs between utilitarian attributes, it diminishes for altruistic trade-offs. Moreover, the trade-offs between utilitarian and altruistic attributes reverse the compromise effect, i.e., leading to a preference for extreme options. We also demonstrate that impression management moderates this effect.
Geophysical and geospatial insights into surface and subsurface characteristics for groundwater potential analysis, Ras Sudr, West Sinai, Egypt
Authors: Metawee Mona , Araffa Sultan A. S. , Othman Amal , Alfy Mohamed El 
Published: November 2024

AbstractRas Sudr has garnered significant interest owing to various initiatives aimed at expanding and developing this area. It holds considerable strategic importance, serving as a key development hub in Sinai and a focal point for tourism destination. Moreover, it has a remarkable event with flashfloods which can be utilized for groundwater or direct usage. Integrating geophysical and geospatial analyses to study the surface and subsurface characteristics as well as identify groundwater potential areas in Ras Sudr, west-central Sinai is the main objective of this study. Firstly, geophysical data including gravity and magnetic methods have a crucial importance in qualitative and quantitative interpretation of the subsurface elements. Filtering techniques were implemented to distinguish between regional and residual anomalies. Geophysical data were subjected to the radial average power spectrum technique and 3D Euler deconvolution to identify the depth of the subsurface sources. The structure pattern that characterizes the interested region was defined by employing bandpass filter and edge detection appoarches using residual anomaly maps, regional anomaly maps, tilt derivatives and total horizontal gradient maps reflecting four distinct structural trends; NW-SE parallel to the Gulf of Suez, NEE-SWW parallel to the Syrian arc system, N-S parallel to the the Nile Valley, and NNE-SSW parallel to the Gulf of Aqaba. A basement relief map was constructed using 3D magnetic modelling showing that the depth of the basement ranges from 1.6 to 6.3 km. Secondly, the remote sensing data including Sentienl-2 and SRTM datasets were employed to extract the surface analyses in the GIS environment to develop the occurrence of groundwater potentiality utilizing seven factors; LU-LC, soil, geology, slope, drainage network and lineament density and rainfall data of the study area which were ranked from 1 to 5 and weighted according to their effective contribution to the infiltration of groundwater using AHP-GIS based multi criteria method. The resulting Groundwater Potential zone (GWPZ) was categorized into five zones from poor to excellent and validated using 41 observed wells. A significant quantity of wells was identified in the areas of high potential located to the west of the region, while five wells were situated within the moderate potential zone. Thereby, the GWPZ map identifying locations with viable groundwater resources suitable for habitation, development and economic plans in Sinai for decision makers.
Ethnonutritional study of fruits of Solanum aethiopicum L. and Solanum melongena L. in the district of Galim (Bamboutos) in West Cameroon
Authors: Epanda Adriel Martin Collet , Tchiaze Ifoue Alice Virginie , Kendine Vepowo Cédric , Demasse Mawamba Adelaide , Fogang Mba Aymar Rodrigue , Dongho Dongmo Fabrice Fabien , Gouado Inocent 
Published: November 2024

AbstractSolanum aethiopicum L. and Solanum melongena L. are endemic plants whose fruits are used in the composition of cultural dishes in West Cameroon including Yellow, Black, Eggplant, Nkui and Okra sauces. This work aims to conduct an ethnonutritional study based on the knowledge and consumption of these dishes. Surveys were carried out including 480 persons of the district of Galim (Kieneghang I and Mbezaté) in the Bamboutos division in West Cameroon and the results revealed that the vernacular and common names for Solanum aethiopicum L. and Solanum melongena L. are respectively “Shusshui” and “sweet egglant”; “Nzuinzuiè” and “bitter eggplant”. These fruits are rounded and spindle in shape. The fruits of Solanum aethiopicum L. exist in green, yellow and red colors with a mild flavor, while those of Solanum melongena L. are red and bitter. These fruits are preserved by sun-drying, smoking, and parboiled before drying. Their cultivation is traditional with a duration of 3–7 months using organic and chemical fertilizers. The age group 41–50 years had a good knowledge of fruits while the age group over 60 years had a better consumption frequency of eggplant-dishes. In addition, these fruits have important cultural values during traditional ceremonies at births, weddings, funerals, symbolisms such as acceptance, reconciliation, hospitality, consideration, and valorisation. These populations had knowledge for the prevention and or treatment of diabetes (6.66%), high blood pressure (25%), obesity (13.54%), cancers (1.66%) and mouth ulcers (2.70%). The valorization of these fruits could constitute a means of preserving cultural heritage.