bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free radical scavenging activity of zinc oxide nanoparticles biosynthesised using Aspergillus carneus
Authors: Ghareib Mohamed , Abu Tahon Medhat , Abdallah Wafaa E. , Hussein Mahmoud 
Published: July 2019

Zinc oxide nanoparticles (ZnO NPs) were confirmed in this work as a good antioxidant source. They were biosynthesised by the preformed biomass of Aspergillus carneus when contacted with 1 mM zinc nitrate solution of pH 9 after 24 h at 150 rpm and 30°C. The biosynthesised NPs were moderately distributed, quasi‐spherical in shape with clear edges and the average size of 8–12 nm. The NPs retained full stability at 4°C for at least six months. Their zeta potential was found to be 18.3 mV. Crystalline nature of the ZnO NPs was suggested from diffraction rings appeared as lighted spots on the selected area electron diffraction pattern and confirmed by the X‐ray diffraction analysis. High radical scavenging activities (RSA) were found against peroxide () and 2,2–diphenyl‐1‐picrylhydrazyl (DPPH). Good activities were also recorded against hydroxyl (OH−) and superoxide () radicals. This potential RSA can be rendered to the adsorbed biomolecules on the NPs surface especially the phenolic compounds detected by Fourier transform infrared analysis.
In-vitro-Untersuchungen zur Weidenmistel an verschiedenen humanen Tumorzelllinien
Authors: Felenda Jennifer E. , Gruber Kim , Pacifico Severina , Turek Claudia , Beckmann Christiane , Stintzing Florian C. 
Published: July 2019

ZusammenfassungTraditionell werden pharmazeutische Zubereitungen der Weidenmistel häufig bei der Therapie von Blasen- und Nierenzellkarzinomen eingesetzt. Dennoch existieren bislang nur wenige wissenschaftliche Untersuchungen zu Wirkmechanismen von Weidenmistelpräparaten. Daher wurde mithilfe verschiedener Testverfahren die Hemmung der Viabilität von Tumorzellen durch den Weidenmistelextrakt Iscucin® Salicis bestimmt und die beteiligten Mechanismen untersucht. Des Weiteren wurde die Hemmung der Zellmigration analysiert.
Ergebnisse Der Extrakt hemmte Zellwachstum und -migration in vitro, wobei die Sensitivität der einzelnen Tumorzelllinien variierte. Vor allem sprachen neuroepitheliale Tumorzellen und Bronchialkarzinomzellen gut an. Zudem wurden pro-apoptotische Marker aktiviert. Klinische Untersuchungen stehen aus, um zu klären, bei welchen Tumoren das größte Potenzial für eine Behandlung mit Iscucin® Salicis besteht.
Nebenwirkungsmanagement der Opioid-Therapie
Authors: Wirz Stefan 
Published: July 2019

ZusammenfassungÜber 6 Millionen Menschen in Deutschland leiden unter stark beeinträchtigenden
chronischen Schmerzen. Wegen der begrenzten analgetischen Effektivität und der
Toxizität von Analgetika der Stufe 1 des WHO-Stufenschemas ist der Einsatz von
Opioiden (Stufe 2 und 3) oft die einzige Therapieoption. Die hohe Inzidenz von
Opioid-Nebenwirkungen bedingt jedoch eine hohe Abbruchrate. Daher beruht der
Erfolg einer Opioid-Schmerztherapie entscheidend auch auf dem Management der
Verträglichkeit und der Sicherheit der Behandlung. Die meisten
Opioid-Nebenwirkungen, wie z. B. Übelkeit oder Sedierung, treten überwiegend in
der Anfangsphase der Therapie auf. Die Opioid-induzierte Obstipation dagegen
kann für die gesamte Dauer der Opioid-Therapie persistieren. Laxantien als
Erstlinientherapie lösen das Problem nur bei einem Teil der Betroffenen. Als
Zweilinientherapie können Opioid-Rezeptorantagonisten eingesetzt werden, wie
Naloxon, oral applizierbares Naloxegol oder subkutanes Methylnaltrexon. Auch das
Management weiterer häufiger Opioid-Nebenwirkungen wie Übelkeit und Erbrechen,
Sedierung, Pruritus, Miktionsstörung und weiteren wird vorgestellt.
OPSCC: lokoregionäre Kontrolle für besseres
Überleben
Authors: Dost Philipp 
Published: July 2019

Caula A et al. Correlation between the duration of locoregional control and
survival in T1-T2 oropharyngeal cancer patients. Eur Arch Otorhinolaryngol 2019;
doi: 10.1007/s00405–019–05293-z
HNO-Ärzte der Universität Paris-Saclay untersuchten bei Patienten mit
oropharyngealem Plattenepithelkarzinom (OPSCC) den Zusammenhang zwischen der
Zeit bis zum Lokalrezidiv und dem Überleben.
Ist Burnout eine Folge des Arbeitslebens?
Authors: Seemüller Florian , Allwang Christine , Beraldi Anna 
Published: July 2019

ZUSAMMENFASSUNGIn Literatur und Laienpresse kursieren Hunderte Definitionen zu Burnout. Obwohl sich die DGPPN bereits 2012 klar positioniert hat und eine enge Definition veröffentlicht hat, wird der Begriff teilweise immer noch inflationär gebraucht. Dabei gab es bereits mit dem Begriff der Neurasthenie vor über 100 Jahren den Versuch, arbeitsbezogene psychische Störungen nosologisch einzuordnen. Aktuell besteht in Deutschland weitgehender Konsens Burnout als Risikostadium zur Entwicklung einer seelischen Erkrankung aufzufassen. Ätiologisch ist vor dem Hintergrund eines biopsychosozialen multifaktoriellen Modells anzunehmen, dass eine mit dem Alter physiologisch abnehmende Belastbarkeit bei gleichbleibender oder teilweise sogar steigender seelischer Arbeitsbelastung über die Lebensspanne ein wesentlicher Faktor ist. Auf Symptomebene kommt es nach ausreichender Erholung und/oder Arbeitsabstinenz in der Regel relativ rasch zu einer deutlichen Besserung und teilweise sogar vollständigen Genesung. Um diesen Zustand zu erhalten und das Risiko einer nachfolgenden Erkrankung wie z. B. einer Depression oder einer Suchterkrankung zu reduzieren ist eine Modifikation der äußeren Bedingungen (z. B. Stärkung von Ressourcen, Reduktion der Arbeitslast) unumgänglich. Erfahrungsgemäß lässt sich dies nur über eine Änderung innerer aufrechterhaltender Faktoren wie individueller Stressverstärker oder fester Glaubengrundsätze erreichen. Einige zum Teil auch wissenschaftlich gut evaluierte Präventionsprogramme sind hierfür verfügbar.
Return to Work – berufliches Entlassmanagement
Authors: Hamann Johannes , Brieger Peter 
Published: July 2019

ZUSAMMENFASSUNGPsychische Erkrankungen sind einerseits mittlerweile die dritthäufigste Diagnosegruppe bei Arbeitsunfähigkeit, und die häufigste Ursache für Frühverrentungen. Auf der anderen Seite haben Arbeit und Berufstätigkeit einen positiven Effekt auf den Krankheitsverlauf psychisch Kranker. Akute psychische Krisen, die eine stationäre Krankenhausbehandlung erforderlich machen, reißen die Betroffenen teilweise über längere Zeiträume aus ihren Beschäftigungsverhältnissen. Um Jobverluste zu vermeiden benötigt diese Gruppe besondere Interventionen, die unter dem Begriff „berufliches Entlassmanagement“ zusammengefasst werden können.
Erfolg einer endoskopischen Behandlung der
strahlungsinduzierten Dysphagie
Authors: Lehnerdt Götz 
Published: July 2019

Abu-Ghanem S et al. Endoscopic Management of Postradiation Dysphagia in Head and
Neck Cancer Patients: A Systematic Review. Ann Otol Rhinol Laryngol 2019; doi:
10.1177/000348941983756
Im Rahmen einer Literaturrecherche untersuchten Ärzte der Klinik für
Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie der Stanford-Universität
Erfolgsrate und das Sicherheitsprofil der zur Verfügung stehenden
endoskopischen chirurgischen Optionen zur Behandlung einer
strahlungsinduzierten Dysphagie bei Kopf- und Halskrebspatienten nach einer
organerhaltenden Therapie.
Recent Progress in Equilibrium Acidity Studies of Organocatalysts
Authors: Li Zhen , Li Xin , Cheng Jin-Pei 
Published: July 2019

This account summarizes our recent work on the pK
a scales of some frequently used organocatalysts, especially those of hydrogen-bond-donor catalysts and stronger Brønsted acid catalysts. Most of these pK
a values were obtained by the Bordwell overlapping indicator method, which is known to provide high accuracy. Linear free-energy relationships associated with pK
a values are discussed in relation to understanding of reaction mechanisms.1	Introduction2	Single Hydrogen-Bonding Donors2.1	Proline-Type Organocatalysts2.2	Cinchona Alkaloids Bearing a Hydrogen-Bonding Donor in the 6′-Position3	Double-Hydrogen-Bonding Donors3.1	Thioureas3.2	Squaramides3.3	BINOLs4	Stronger Brønsted Acids5	N-Heterocyclic Carbenes6	Summary and Outlook
Intra-aortic Balloon Pump—Current Status
Authors: Kanchi Muralidhar , NV Arun Chandran 
Published: July 2019

AbstractCardiac failure is an ever-growing public health concern confronted by both developed and developing nations of the world. Intra-aortic balloon pump (IABP) is a circulatory assist device that is used to support a failing left ventricle. IABP is designed to augment myocardial perfusion by increasing coronary blood flow during diastolic phase of the cardiac cycle and unloading the left ventricle during systolic phase. Intraoperative IABP is extremely useful when facing difficulty to wean from cardiopulmonary bypass. Until the controversy is resolved, personal experience and decision of the physician and patient circumstances may form the basis for the IABP use in a clinical setting with acute left ventricular failure.
Continuing Patient Care during Electronic Health Record Downtime
Authors: Larsen Ethan , Hoffman Daniel , Rivera Carlos , Kleiner Brian M. , Wernz Christian , Ratwani Raj M. 
Published: July 2019

Introduction Electronic health record (EHR) downtime is any period during which the EHR system is fully or partially unavailable. These periods are operationally disruptive and pose risks to patients. EHR downtime has not sufficiently been studied in the literature, and most hospitals are not adequately prepared.
Objective The objective of this study was to assess the operational implications of downtime with a focus on the clinical laboratory, and to derive recommendations for improved downtime contingency planning.
Methods A hybrid qualitative–quantitative study based on historic performance data and semistructured interviews was performed at two mid-Atlantic hospitals. In the quantitative analysis, paper records from downtime events were analyzed and compared with normal operations. To enrich this quantitative analysis, interviews were conducted with 17 hospital employees, who had experienced several downtime events, including a hospital-wide EHR shutdown.
Results During downtime, laboratory testing results were delayed by an average of 62% compared with normal operation. However, the archival data were incomplete due to inconsistencies in the downtime paper records. The qualitative interview data confirmed that delays in laboratory result reporting are significant, and further uncovered that the delays are often due to improper procedural execution, and incomplete or incorrect documentation. Interviewees provided a variety of perspectives on the operational implications of downtime, and how to best address them. Based on these insights, recommendations for improved downtime contingency planning were derived, which provide a foundation to enhance Safety Assurance Factors for EHR Resilience guides.
Conclusion This study documents the extent to which downtime events are disruptive to hospital operations. It further highlights the challenge of quantitatively assessing the implication of downtimes events, due to a lack of otherwise EHR-recorded data. Organizations that seek to improve and evaluate their downtime contingency plans need to find more effective methods to collect data during these times.
Distribution Network Reliability Evaluation with Load Importance Degree and Isolated Island Operation
Authors: Li Guowei , Zeng Qinghui , Liu Hao , Wang Junbo , Luo Rongbo , Li Hui , Zhang Tao 
Published: July 2019

Abstract
Supply power for important load in priority is the fundamental principle during power shortage. For the reason that the existing power load classification principle is too simple to compare the importance degree of loads at the same level, this paper proposed a comprehensive evaluation method of load importance degree. First, an indicator system is established to measure load importance. Then a comprehensive evaluation model is designed basing on improved rank correlation analysis method, which sets weights based on subject and object analysis and calculates the importance degree value according 4 indicators, including outage cost. Finally, evaluating the distribution network reliability with load importance degree. Simulation results on IEEE-RBTS BUS6 system shows the validity and practicality.
Analysis and Suggestion on Neutral Grounding Mode for Shanghai Distribution Network Considering Power Supply Reliability
Authors: Jun Liu , Ling Shi , Haifeng Tang , Lei Yang , Fan Yang 
Published: July 2019

Abstract
The demand for reliable power supply in large cities is the major concern for both consumers and company, and power outages have uprising influence on economic losses and social impacts. With the continuing growth of underground cable ratio in Shanghai, the medium-voltage distribution network structures are experiencing changes. The choice of grounding method has considerable impact on operation safety and system reliability. It is crucial to carry out in-depth and systematic analysis on different grounding modes. This paper analyzes the technical route, insulation coordination, protection configuration and system reliability for neutral grounding mode for Shanghai distribution network with regard to the development status and safety requirements of urban medium voltage distribution grid, providing effective technical principles and engineering proposals for system planning and safe operation.
A Review of the Power Metering Systems in Australia, Britain and Guangdong Electric Market
Authors: Zhang Kaijie , Yang Kan , Xie Kang , Sang Maosheng , Xie Dunjian , Zhang Lixing , Bao Minglei 
Published: July 2019

Abstract
With the development of electric market reform, electricity spot market pilot is about to be launched in China. However, facing more complex settlement process in a competing environment, the existing power metering system may not meet the requirements of modern power market. Thus, it is an urgent problem to determine the improvements performances based on the existing power metering system. This paper will focus on this problem and propose suggestions based on the experience of domestic and foreign electricity market. In this paper, electric power metering systems of Australia, Britain and China (Guangdong Province) is firstly studied and presented in five significant aspects, including market participants, market structure, metering point, acquisition cycle and business managements. Then, their commons and differences will be further analysed and compared as reference of Chinese practice. Finally, suggestions of power metering system construction are proposed in China’ electric power market reform.
Study on Vibration Noise Signal Characteristics of 10kv Distribution Transformer under Different Load Conditions
Authors: Zhang Zhendong , Xu Shurong , Zhang Jiangong , Liu Hao , Huang Xiaolong , Wang Zhelong , Zhao Lihua 
Published: July 2019

Abstract
In order to study the effect of load on the transformer vibration noise. In this paper, a S13-M-200/10 distribution transformer is taken as the experimental subject and an experimental platform was built to collect the vibration noise signals of the transformer under no-load, short-circuit, resistive load, inductive load and different load rate. These signals are used to study the vibration characteristics of transformers under different load rate and load characteristics. The results show that the amplitude of the 100Hz fundamental frequency increases with the increase of the load rate, and the amplitude of other frequency basically has no change. The inductive load will cause the increase of the amplitude of 150Hz and 250Hz components, and the amplitude increases with the increase of the inductive load. The research results of this paper provide a theoretical basis for the condition monitoring of transformers based on vibration noise signal.
An Improved Finite Control Set Model Predictive Current Control Strategy for Five-Phase PMSMs
Authors: Han Xuedong , Wang Haihua , Zhang Zhen , Fan Ying , Wang Wusen 
Published: July 2019

Abstract
In this paper, finite control set model predictive current control strategy for five-phase permanent magnet synchronous motor is analysed. At first, virtual voltage vectors are adopted to avoid including all the 32 voltage vectors of five-phase inverter into the control set. Besides, under different rotor speed, estimated voltage vector is predicted in advance so that a new online updated adaptive control set can be established with proper voltage amplitude and only three vectors. Consequently, current ripples and computational burden can be much reduced. At last, experimental results are presented and indicate the performance improvement of the proposed control strategy.
A Dynamic Equivalent Method for Electromagnetic Transient Simulation and Its Application in East China Power Grid
Authors: Dou Fei , Wang Weiyuan , Yang Mengmeng , Huang Qinxin , Gao Yifan 
Published: July 2019

Abstract
There is an inherent limitation when unbalanced faults in AC system are studied in large scale AC/DC power systems with electromechanical transient simulation. In order to make the electromagnetic transient simulation which is accurate in these situations possible, dynamic reduction must to be done. A method based on support strength of generators is proposed. According to the connection form of low-voltage network with 500kV skeleton buses and whether there are generators in it, three reduction schemes are used to replace the corresponding low-voltage network. The dynamic parameters of equivalent generators are obtained by a time domain aggregation method. The equivalent results of planning data of East China Power Grid in 2020 show that, the method has high accuracy in power flow analysis as well as short circuit calculation. The proposed method greatly simplifies the original system while the characteristic of dynamic response remains.
Research for Participation of Electric Vehicles in the Power System Optimal Dispatching
Authors: Lu Mengke , Du Wei , Li Deyi 
Published: July 2019

Abstract
The rapid development of renewable clean energy and low-carbon transportation has brought new opportunities and challenges to the safety and economic operation of power system. This paper studies the economic dispatching operation of the power system that contains clean energy and large-scale electric vehicles, and establishes the objective function of minimizing the amount of discarded wind power and the lowest cost of thermal power generating units. In order to improve the optimization efficiency, the original system is decoupled into the wind-vehicle-hydro subsystem and the thermal power subsystem according to the characteristics of multi-source output. The two subsystems are connected by the load balance and the reserve constraints of the system, and their respective scheduling models are given respectively. In this paper, an improved random black hole particle swarm optimization (IRBHPSO) algorithm with fast convergence and effective avoidance of local optimization is proposed by combining the black hole theory and particle swarm optimization. The effectiveness and superiority of the improved algorithm were verified on a 10-unit test system. Finally, this paper modifies the IEEE-RTS system according to the proportion of installed capacity of the Northeast Power Grid. The simulation results verified the feasibility of the proposed optimal scheduling model and the effectiveness of the algorithm, which provides strategies and feasible suggestions for the large-scale electric vehicles to participate in the economic dispatching operation of the power system.
Study on the Optimal Planning of Distributed Renewable Power Generation Based on Long-Term Sequence Simulation in Regional Distribution Network
Authors: Feng Kaihui , Sun Wenwen , Huang Bibin , Hu Jing , Du Dan , Wang Dan 
Published: July 2019

Abstract
Distributed renewable power generation has obvious volatility and randomness. It has different impacts on voltage, power loss, power quality and so on with different integration schemes in distribution network. It could improve the distribution network voltage level and reduce the power loss with reasonable integration scheme. Conversely, if the integration scheme is not reasonable, it will have bad impacts on power loss and voltage level of the distribution network. TO achieve the optimal planning scheme of Distributed renewable power Generation, a optimal planning method has been proposed in this paper. In the method, the minimum power loss of region distribution network as the optimization objective, long-term sequence simulation with wind energy, solar energy and load actual dates for at least one year in a row has been used to get the annual power loss and voltage qualified rate on different integration schemes. A model is verified by an actual case, which is a large-scale distribution network including multiple feeders. It is shown that the feasibility of the integration scheme. Secondly, the operation requirements of Distributed renewable power generation have been proposed based on the simulation analysis of impacts on voltage distribution of Distributed renewable power generation with PQ and PV operation mode. It is shown that appropriate voltage control strategy could be used to enhance voltage qualified rate.
Research on Quantitative Analysis of Investment Benefit of Integrated Energy System in Park of Multi-investors
Authors: Huang Bibin , Yan Hu , Hong Bowen , Yang Bo , Bai Jianshi , Du Dan , Wang Dan 
Published: July 2019

Abstract
The industrial park has become an important experimental area for power reform. Under the conditions of incremental distribution market liberalization, diversified power sources and loads, the investment interface of park integrated energy system has been divided, investment entities have become diversified, and the analysis of investment benefits has become complex. The paper proposes the park IES operation models on different interfaces, studies the methodology of calculating the full lifecycle investment benefit of different components of park IES. Based on the typical cases, it proposes the future direction of business development of park integrated energy service provider.
Economic Analysis of Energy Storage System Installation by Industrial Users
Authors: Wentao Sun , Haikun Li , Chen Wu , Boliang Liu , Xingning Han 
Published: July 2019

Abstract
Considering the demand of installing energy storage system by industrial users to reduce the basic electricity cost and increase the income of electricity sale, this paper proposes a detailed charging and discharging strategies calculation method to obtain the annual income. Based on the annual load historical data of industrial users, the charging and discharging modes and detailed strategies are determined according to the load characteristic and the electricity price period. Considering the influence of large and dense load on the peak load after peak shifting by storage system, a method of new peak load correction based on dichotomy iteration and backtracking mechanism is proposed. The case verification show that the monthly income is significantly affected by the industrial load characteristics. This method provides accurate income analysis for industrial users to ensure validity and economy of storage system investment.