bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphisms of the Highly Expressed IL-6 Gene in the Papillary Thyroid Cancer Susceptibility Among Chinese
Authors: Li Honghui , Dai Hao , Li Huajing , Li Baiya , Shao Yuan 
Published: April 2019

Background:
Papillary thyroid cancer (PTC) is the cardinal histologic type of
thyroid cancer, which is the most prevalent kind of endocrine malignancy. The
expression of IL-6 is found higher in thyroid carcinoma (THCA) samples than paired
normal tissues based on The Cancer Genome Atlas (TCGA) and Genotype-Tissue
expression (GTEx) database. In this study, we aimed to investigate the association
between interleukin-6 (IL-6) polymorphisms and the PTC risk.

Methods:
A case-control study was designed using the following data: 241 PTC patients
and 463 healthy controls. Five single nucleotide polymorphisms (SNPs) in IL-6 were
selected and genotyped using Agena MassARRAY technology.

Results:
Our results revealed that SNP rs1800796 was associated with an increased
PTC risk in co-dominant model (p = 0.042) and dominant model (p = 0.027). Rs1524107
was also a risk factor for PTC susceptibility in co-dominant model (p = 0.003), dominant
model (p = 0.002) and log-additive model (p = 0.044). Moreover, rs2066992 significantly
increased the PTC risk in co-dominant model and dominant model (p = 0.011, p = 0.009,
respectively). Additionally, rs2069837 variant elevated the PTC risk based on dominant
model (p = 0.041). In silico analysis, GTEx results for rs1800796, rs1524107 and
rs2066992 variants are known to be associated with IL-6 gene expression. Using
HaploReg, we found rs1800796, rs1524107 and rs2066992 in LD with functional
importance.

Conclusion:
Our study indicates that IL-6 variants may be a risk factor involved in the
pathogenesis and development of PTC.
Chronic Submerged Implant Infection Treated with Immediate Implantation and Guided Bone Regeneration: A Case Report
Authors: Al-Juboori Mohammed J. , Al-Shaeli Ali J. , Radhi Hani , Filho Luiz C. M. , Al-Attas Mohammed A. 
Published: April 2019

Introduction:
Early implant infection and failure can be addressed by either implant maintenance or immediate replacement and bone regeneration at the defect site.

Methods:
In this study, six patients with chronic sinusitis at the implant site were treated with implant removal and curettage to remove the infected and inflamed soft tissue. A new implant was immediately screwed into the same socket, and a Guided Bone Regeneration (GBR) procedure was performed to regenerate the lost bone at the site. After the patients underwent the second surgery, the sinusitis disappeared, and new bone formed around the implant, achieving good implant stability.

Conclusion:
The implant was loaded, and no complaints were reported during the follow-up period. Chronic implant infection treated with implant removal and immediate replacement plus GBR resulted in stable new implants with new bone formation.
Acción antimicrobiana de algunas plantas de uso medicinal en Chile. I.
Authors: Lazo Waldo 
Published: April 2019

El desarrollo de Stapbylococcus aureus y Bacillus subtilis fue inhibido por la decocción y el extracto en etanol de cáscara de frutos de Punica granatum L., raiz de Geum quellyon Sweet, corteza de Quillaja saponaria Mol.; la decocción y el extracto en acetato de etilo de cotiledones de Lucuma bifera Mol.; la decocción y el extracto en etanol o acetato de etilo de hojas y tallos de Calceolaria thyrsiflora Graham, Sphacele salviae (Lindl.) Briq. Haplopappus baylahuen Remy y la decocción y los extractos en etanol, acetato de etilo y cloroformo de Luma chequen (Mol.) A. Gray. El desarrollo de Escherichia coli fue escasamente inhibido por el extracto en acetato de etilo de cotiledones de ·L. bífera Mol. El desarrollo de Acremonium falciforme fue inhibido por la decocción y los extractos en etanol o acetato de etilo de hojas y tallos de C. thyrsifiora y H. baylahuen y por los extractos en etanol o acetato de etilo de hojas y tallos de S. salviae. Ninguna de las decocciones o extractos inhibió el desarrollo de Candida albicans.
Notas micológicas y bacteriológicas. Basidiomycetes y Streptomycetes de Chile.
Authors: Lazo Waldo 
Published: April 2019

Se comunica la recolección de Clavaria nigricans, Tremellodendrospis pusio, Battarrea stevenii, Coltricia perennis, Streptomyces albus, S. antibioticus, S. cliifornicus, S.coelicolor, S. flavogliseus, S. Fradiae, S. globisporus, S Globossus, S.griseus, S. melanocyclus, S.odorifer, S. olivaceus, S. parvus, S. phaeochromogenes, S. rimosus, S. roseochromogenes. S. violaceus-niger; S.violaceus-ruber, S. viridis.
Micosis superficiales en pacientes de servicios dermatológicos de la V región: estudio de prevalencia en el periodo 1984-1989
Authors: Piontelli L. E. , Toro S. M., M. A. , Casanova Z. D. , Jara D. 
Published: April 2019

Con el objeto de establecer la prevalencia de los agentes micóticos en relación a edad, sexo y tipo de lesión, se estudiaron en el periodo 1984-1989, 1180 muestras clínicas (546 masculinos y 634 femeninos) positivas a hongos patógenos, en un número similar de pacientes provenientes de consultorios dermatológicos y privados. El 69% de ellos fueron positivos a dermatofitos y un 30% a levaduras
Sob a bandeira vermelha: A “Revolução” Brasileira nas páginas de El Machete.
Authors: Sousa Fábio Da Silva 
Published: April 2019

O presente artigo objetiva discutir matérias que o periódico comunista mexicano El Machete publicou sobre a Insurreição Comunista no Brasil de 1935 e das campanhas pela libertação de Luís Carlos Prestes. Fundado em 1924 e órgão central do Partido Comunista Mexicano (PCM), o El Machete dedicou atenção especial ao Brasil no decorrer do ano de 1936 e início de 1937, período em que Getúlio Vargas potencializou a repressão aos comunistas brasileiros e, consequentemente, decretou o regime ditatorial do Estado Novo. Por meio de uma análise comparativa de tais matérias, este artigo objetiva elucidar como os comunistas mexicanos leram e interpretaram esse período da história brasileira, nas páginas do seu importante periódico de propaganda política.
Relações de poder e bem comum na Baixa Idade Média italiana (séc. XIII-XIV)
Authors: Miatello André Luis Pereira 
Published: April 2019

Este artigo pretende discorrer sobre o entendimento de bem comum/utilidade comum nas práticas políticas da Baixa Idade Média. O interesse volta-se para a discussão acerca da possibilidade de haver ação política e esfera política no período medieval e de saber como esses elementos constituíam critérios de sociabilidade e governabilidade. Compreende-se bem comum como categoria ordenadora do agir civil, mas que transcende os agentes históricos e as instituições: o bem comum constitui a referência de práticas que visam a utilidade comum que, tangível aos cidadãos e instituições, possibilita a vida coletiva e a justiça social.
MATA, Sérgio da. A fascinação weberiana. As origens da obra de Max Weber. Belo Horizonte: Fino Traço, 2013.
Authors: Rodrigues da Cunha Marcelo Durão 
Published: April 2019

Resenha referente ao livro MATA, Sérgio da. A fascinação weberiana. As origens da obra de Max Weber. Belo Horizonte: Fino Traço, 2013.
AN APPROACH TO DEVELOP A MOTION-SENSITIVE, LOCALLY MULTIPLAYER-HYBRID (MULTIPID) 3D VIDEO GAME
Authors: KAYAR Gizem 
Published: April 2019

Playing video games has been gaining increased interest over the last two decades regardless of age, gender and any kind of status. Video games are generally controlled via frequently used input devices such as game controllers or mouse and keyboard. However, there are also newer technologies which can detect human motion through sensors. This technology enhances the game-play experience due to its interactivity level and therefore, such an experience embraces many players more than traditional controllers. The term “Hybrid” is used for both the multi-genre games and for games integrating conventional controllers together with new technology devices, e.g. motion-sensitive devices. In this paper, we use the term for the latter. Our aim is to provide the game developers a roadmap to generate a 3D hybrid game in order to enhance the game-play experience where we mainly control the game with keyboard but also integrate Kinect to sense human motion and solve interactive puzzles at the end of each level. Besides, we also suggest to enable the multiplayer mode for some interactive puzzles to challenge the players and observe their contentedness in terms of game-play. After this experience, we named this game model as MultipId game-model as it combines the features of both multiplayer and hybrid modes. We developed a game employing this model which is discussed in the Results section. We believe that increasing the number of MultipId games gives a competitive edge over existing single-player games employing only traditional controllers.
Intertextuality, Isiac Features, and the Shaping of the Sacred Feminine in Trimorphic Protennoia (NHC XIII, 1)
Authors: Sassi Nicolò 
Published: April 2019

The aim of this paper is to bring to light through intertextual analysis some dimensions of continuity between the Hellenistic and Imperial theology of Isis and the figure of the Sacred Feminine as it appears in the Trimorphic Protennoia (NHC XIII 1). Instead of attempting to establish a diachronic (=historical) relationship of dependence between sources (e.g., borrowing, allusion, influence), this study establishes correspondences that can be traced on the literary level. Through a reception-oriented analysis, it will be possible to show the continuity between the Isiac religion and the late ancient mysticism of the Trimorphic Protennoia. A late ancient reader would have experienced the Nag Hammadi text in dialogue with Isiac traditions, and this literary dialogue with the Isiac religion would have nurtured and shaped their understanding of the sacred feminine described in the Trimorphic Protennoia.
Silver nanoparticle-mediated cellular responses in human keratinocyte cell line hacat in vitro
Authors: Khaled Habas  , Lijun Shang  
Published: April 2019

The interactions between cells and nanoparticles has been the focus of recent research in the area. The effects of AgNPs on skin cell lines for further potential biological applications are highlighted. This study aimed to investigate the mechanism of cytotoxic and genotoxic effects of AgNPs nanoparticles on human skin keratinocytes (HaCaT). Genocytotoxic effects of AgNPs was assessed using changes in various cellular parameters of HaCaT cells involving viability, superoxide anion radical production, lactate dehydrogenase release and the levels of the antioxidant enzymes, namely, Catalase, Glutathione peroxidase (GPX) and Superoxide Dismutase (SOD). Superoxide anion was detected using nitroblue tetrazolium NBT reduction assay. LDH levels was evaluated using the standard kit, and activity of antioxidant enzymes such as catalase (CAT), glutathione peroxidase 1 (GPX-1) and superoxide dismutase 1 (SOD-1) were quantified using qPCR. Our results indicated that AgNPs caused severe HaCaT oxidative damage, accompanied by increased the production of superoxide anion levels as well as significant decrease in endogenous antioxidant enzyme of SOD, CAT, GPX expression involved in HaCat cells in vitro. Our study suggests that AgNPs exposure increased oxidative stress levels. Moreover; the low cytotoxic effect observed on human HaCaT keratinocytes suggested that these nano-compounds have a potential toxic effect at the skin level only after long-term exposure.
Structural and electrical properties of zno varistor with different particle size for initial oxides materials
Authors: Susan A Amin  
Published: April 2019

We report here structural, electrical and dielectric properties of ZnO varistors prepared with two different particle sizes for initial starting oxides materials (5 µm and 200 nm). It is found that the particle size of ZnO does not influence the hexagonal wurtzite structure of ZnO, while the lattice parameters, crystalline diameter, grain size and Zn-O bond length are affected. The nonlinear coefficient, breakdown field and barrier height are decreased from 18.6, 1580 V/cm and 1.153 eV for ZnO micro to 410 V/cm, 7.26 and 0.692 eV for ZnO nano. While, residual voltage and electrical conductivity of upturn region are increased from 2.08 and 2.38x10-5 (Ω.cm)-1 to 4.55 and 3.03x10-5 (Ω.cm)-1. The electrical conductivity increases by increasing temperature for both varistors, and it is higher for ZnO nano than that of ZnO micro. The character of electrical conductivity against temperature is divided into three different regions over the temperature intervals as follows; (300 K ≤ T ≤ 420 K), (420 K ≤ T ≤ 580 K) and (580 K ≤ T ≤ 620 K), respectively. The activation energy is increased in the first region from 0.141 eV for ZnO micro to 0.183 eV for ZnO nano and it is kept nearly constant in the other two regions. On the other hand, the average conductivity deduced through dielectric measurements is increased from 2.54x10-7 (Ω.cm)-1 for ZnO micro to 49x10-7 (Ω.cm)-1. Similar behavior is obtained for the conductivities of grains and grain boundaries. The dielectric constant decreases as the frequency increases for both varistors, and it is higher for ZnO nano than that of ZnO micro. These results are discussed in terms of free excited energy and strength of link between grains of these varistors.
STRUCTURAL AND FUNCTIONAL INDICATORS OF ECHOCARDIOGRAPHY IN HEALTHY REPRESENTATIVES OF INDIGENOUS AND NON-ORGANIZED URBANIZED POPULATION OF GORNAYA SHORIA
Authors: Arkhipov O. G. , Suslova N. S. , Sumin A. S. 
Published: April 2019

Aim: To study the structural and functional parameters of echocardiography in healthy representatives of the urban Shor population, including men and women.Material and Methods. The study included 96 indigenous and 66 non-indigenous urbanized residents of Gornaya Shoria, matched by age and divided according to ethnic and gender characteristics into 4 groups: indigenous men (n=40), indigenous women (n=56), non-indigenous men (n=32), and non-indigenous women (n=34). All individuals underwent echocardiographic study. Body surface area-indexed left and right heart structural parameters, pulse wave Doppler data, data on propagation atrioventricular flow rates, and spectral Doppler tissue data were studied.Results. According to the results of anthropometry, men and women of Shor nationality had a lower body mass and body surface area compared with the corresponding values in men and women of non-indigenous nationality (p<0.0001 in all cases). However, the indices of the thickness of the interventricular septum, the posterior wall of the left ventricle, left ventricular mass and stroke volume, the diameter of the aorta, and the anterior-posterior dimension of the right ventricle were significantly higher in the group of indigenous women compared to non-indigenous ethnic groups. (p<0.01 in all cases). The values of the left ventricular end-diastolic volume, left atrial volume, pulmonary artery diameter were significantly higher in both men and women of indigenous nationality relative to the corresponding female and male comparison groups (p<0.01 in both cases). The tricuspid flow propagation velocity in male Shors was significantly higher than that in non-indigenous men (p<0.01). The Shor nationality was associated with a decrease in body surface area and increases in aortic diameter indices, pulmonary artery, left ventricular posterior wall, left ventricular myocardial mass index, pulmonary artery index, right atrial area index, and tricuspid flow propagation velocity; only a decrease in body surface area was associated with the female sex.Conclusion. In healthy representatives of the indigenous population of Gornaya Shoria, ethnic differences in the structural and functional parameters of echocardiography prevailed over gender-related differences.
THE ROLE OF MYOCARDIAL REVASCULARIZATION IN THE SURVIVAL OF PATIENTS WITH ALTERED CORONARY BLOOD FLOW DETECTED BY TRANSTHORACIC ULTRASOUND
Authors: Kamenskikh M. S. , Zagatina A. V. , Zhuravskaya N. T. , Fedotov Yu. N. , Shmatov D. V. 
Published: April 2019

Aim of the study was to identify the effects of myocardial revascularization on the prognosis in patients with altered coronary blood flow detected by transthoracic ultrasound.Material and Methods. Four hundred and twelve (412) patients were included in the study. The inclusion criterion was coronary velocity more than 70 cm/s during echocardiography. The study population was divided into three groups: Group 1 comprised patients with high velocities in the coronary arteries detected by ultrasound, in whom myocardial revascularization was performed; Group 2 comprised patients with high velocities in the coronary arteries, in whom myocardial revascularization was not performed and; the Control Group comprised patients with normal coronary blood flow according to ultrasound. The follow-up period was 10–11 months.Results. Seventeen (17) deaths (4.7%) occurred during follow-up. Death rates were 1.6 vs. 8.1 vs. 0% in Group 1, Group 2 and the Control Group, respectively, with a p-value for the difference between Group 1 and Group 2 (p1) of <0.009; and a p-value for the differences compared with the Control group (р2) of <0.03. Death, myocardial infarction, pulmonary edema, and acute coronary syndrome were observed in 27 patients (7.7% of the study group with accelerated blood flow). The rates of these outcomes were 4.9 vs. 11.0 vs. 0% in Group 1, Group 2, and the Control Group, respectively (p1<0.05; p2<0.006). Discussion. The study showed high rates of mortality or acute coronary events in the group of patients with pathologically high coronary flow velocities. The positive effects of revascularization on survival in this group were verified.Conclusions: 1. Left artery coronary flow velocities over 70 cm/s indicate a high probability of death or acute coronary events within 10.5 months.2. Myocardial revascularization has a significant positive effect on the survival rate and incidence of acute coronary events in patients with coronary artery flow velocities greater than 70 cm/s.3. Patients with high coronary blood flow velocities should be referred to coronary angiography or other diagnostic tests without waiting for clinical manifestations and specific symptoms for coronary artery disease.
ANALISIS WACANA PELANGGARAN SIARAN LOMBOK TV DITINJAU DARI UNDANG-UNDANG NOMOR 32 TAHUN 2002 TENTANG PENYIARAN (Studi kasus di Komisi Penyiaran Indonesia Daerah Provinsi Nusa Tenggara Barat)
Authors: Irawati Dewi , Rahmat Lalu Ahmad , Sidharta Yohanes Yulanda Trisula 
Published: April 2019

The phenomenon of violations seen on the glass screen is very diverse ranging from video clips of Sasak songs that show certain body parts, and erotic swaying to news broadcasts that do not blur the faces of perpetrators of crimes and the appearance of one of the product logos in its broadcast program . The violation was analyzed by researchers in accordance with discourse analysis such as text, social statements and the context that developed in the community. To find out the correct broadcast content in violations of Lombok TV broadcasts based on Law Number 32 of 2002 concerning Broadcasting. At the Regional Indonesian Broadcasting Commission of the Nusa Tenggara Province. This study uses a purposive sampling technique with certain criteria and considerations from the research objectives. Data collection was carried out by in-depth interviews with three people from the NTB KPID and one Lombok television person. The conclusions and results of this study indicate that Lombok TV has not fully complied with the mandate of Law No. 32 of 2002 concerning Broadcasting and also the Broadcasting Behavior Guidelines and Broadcast Program Standards that have been set by NTB KPID as guidelines for broadcasting. There are still violations in Lombok TV broadcasts as evidence of this, internal censorship must be increased and continued so that violations do not recur.
The Implementation Right To Attain Second Opinion Patient Of National Health Insurance Participant
Authors: Lukman Muhammad Ikhsan , Sampurno Slamet , Ilyas Amir 
Published: April 2019

This research is empirical juridical research. The research material consists of the primary and secondary data. Primary Data are gained from research subject, whilst secondary data are obtained from document study, this research is analyzed with the qualitative method and explained descriptively. The research result is attained that the law protection design is given by RSUD Haji Makassar with determining the operational procedure standard of patient right poured forth in the Director SK Number 29.02.08 About The Patient Right and Family to consult about disease matter from patient to another doctor is a law protection form preventively which the accusation service and sigh from patient poured forth the Director SK Number 155/TU/RSUD/I/2016 related to the operational procedure standard (SPO) Handling Sigh/Accusation Customer, that SPO is a repressive law protection form. Right implementation obtains the second opinion in RSUD Haji Makassar is not well-implemented maximumly, it is caused by no BPJS Kesehatan regulation accommodating patient right to gain the second opinion.
Legal Protection of Concurrent Creditor on Bankruptcy
Authors: Febryan Khairus , Sartika Dewi 
Published: April 2019

Bankruptcy is a method in the process of debt settlement in Indonesia through the Court, the regulation has amended several times and now the regulation of bankruptcy is regulated in The Act Number 37 Year 2004 of Bankruptcy and Postponement of Debt Repayment. In the Act, provides the debtor legal protection in the case by creditors of mass executions does concern, while the process to protect creditors from receivables refund from the debtor. The creditors are classified into 3 (three) criteria, i.e. : Separatist, Preferen and Concurrent, in this paper discussed about the legal protection to the concurrent creditor which must be clarified in the Act because of its position as a creditor who has no mortgage on his receivables.\
Legal protection, Bankruptcy, Creditors
The Brain Drain And Human Rights
Authors: Jannah Aisyah Wardatul 
Published: April 2019

The terms of brain drain refers to the movement of the skilled people from less developed country to the developed country caused by several factors such as politic unstability, poverty and development problem in the source country in order to seek out for the new opportunity and better quality of life in the receiving country. Since the movement of the brain have increased year by year, it is arises more development problem to the source country in lack of health care acces, poverty continuously and even died. The study resource of this essay conduct from the library, journal and internet resources, to examine the definition and describe the impact which caused by the brain drain. As the consequences, it is resulted that the brain drain has a negative impact to the resource country but in the other hand it has positive impact as well, further it is qualified that the brain drain have a strong relation with the human rights and have arises question does this brain drain can be blamed for the development problem in source country.