bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the effects of stabilized hypochlorous acid on multi-species oral biofilms
Authors:   , Oliva Aherne 
Published: November 2024

Periodontitis and dental caries are two of the most prevalent human diseases, affecting nearly 2 billion worldwide. Persistence is largely attributed to the formation of biofilms (plaque) by oral bacteria, which left undisturbed lead to destruction of surrounding tissues and increase the risk for secondary disease. As current treatments such as mechanical removal and adjunctive therapies can be inadequate, there is a need for new anti-plaque chemical agents. Stabilized hypochlorous acid (sHOCl) has emerged as a potential anti-biofilm agent in areas such as wound therapy but its use in treating oral diseases remains unknown. Therefore, our aim in this thesis was to assess the role of sHOCl as an antimicrobial agent for use in the oral cavity.

We found that at low concentrations, sHOCl was effective in killing bacteria within mixed-species in vitro models resembling periodontitis and dental caries. Moreover, sHOCl displayed higher antibiofilm activity compared to chlorhexidine, whilst not damaging tested oral surfaces. At sub-lethal levels, sHOCl was observed to target multiple cellular components through oxidative stress in Streptococcus biofilms. Simultaneously, work on our models revealed a possible new application of CFSE-based dyes in microscopy for the live-imaging of biofilms. In particular, multi-dye compatibility opens up the possibilities for future research employing mixed-species biofilms. Finally, our preliminary findings also indicate that sHOCl may permit a selective re-growth of biofilms following exposure.

Taken together, the results of this thesis lay the groundwork for investigations of sHOCl as an antibiofilm agent, and continue to push microbial research towardsmore relevant models.
Karakterisasi Sensor Kapasitif Multilayer Untuk Aplikasi Deteksi Kadar Air Pada Proses Pengeringan Rumput Laut Menggunakan Algoritma Fast Fourier Transform (FFT)
Authors: N Andi Rosman , Isdaryanti Isdaryanti 
Published: November 2024

Kandungan kadar air rumput laut pada saat proses pengeringan merupakan salah satu faktor penentu mutu rumput laut. Oleh karena itu, pengukuran persentase kadar air pada rumput laut pada proses pengeringan sangat penting untuk diperhatikan. Telah berhasil dibuat dan dikarakterisasi sensor kapasitif multilayer untuk aplikasi deteksi kadar air pada proses pengeringan rumput laut menggunakan algoritma Fast Fourier Transform (FFT). Sensor dibuat dari substrat PCB Cu berbentuk pola potensial tangga dengan dimensi 5 x 5 cm. Substrat PCB kemudian dilapisi dengan beberapa layer atau lapisan pembentuk NiFe dan pembentuk Cu menggunakan teknik elektro deposisi. Metode penelitian terdiri dari pembuatan sensor, kalibrasi sensor dengan menggunakan metode gravimetri, dan melakukan dua skema pengukuran yaitu pengukuran perubahan nilai ADC sensor sebagai representasi nilai kadar air rumput laut dan pengukuran perubahan nilai frekuensi sensor sebagai representasi nilai kadar air menggunakan FFT. Hasil penelitian menunjukkan bahwa karakteristik sensor berupa gradien garis sensor sebesar 18,866 nilai ADC/(%) kadar air dengan intercept sebesar 68,248 nilai ADC. Sehingga sensor akan mengalami penurunan perubahan nilai ADC sebesar 18,866 setiap kenaikan ataupun penurunan 1% kadar air. Untuk nilai koefisien determinasi R2 sebesar 0,91618 yang menunjukkan bahwa sensor telah mendekati pembacaan nilai kadar air dengan kepresisian yang baik. Berdasarkan hasil pengukuran nilai kadar air rumput laut juga memperlihatkan bahwa dengan menggunakan algoritma FFT pembacaan nilai kadar air rumput laut dapat direpresentasikan dengan nilai frekuensi dari sensor dengan baik. Penelitian ini berkontribusi pada pengembangan teknologi sensor yang inovatif dalam mengukur kadar air selama proses pengeringan rumput laut.
Analisis Nilai CI, HI dan DVH Organ Jantung dengan Teknik IMRT pada Pasien Kanker Payudara Post Mastektomi
Authors: Djohan Jerry , Shafila Naura , Saleha Saleha , Astuty Sri Dewi , Ibrahim Ajeng Anggreny , Pratiwi Ayu Hardianti , Dewang Syamsir 
Published: November 2024

Kanker payudara memiliki angka kejadian tinggi di Indonesia, maka diperlukan pengobatan untuk meningkatkan kelangsungan hidup pasien. Salah satu metode pengobatan yang digunakan adalah radioterapi dengan teknik Intensity Modulated Radiation Therapy (IMRT), yang bertujuan untuk memberikan dosis radiasi yang optimal pada tumor dan meminimalkan paparan radiasi pada organ sehat, seperti jantung. Penelitian ini bertujuan untuk menganalisis distribusi dosis pada organ at risk (OAR) jantung serta mengevaluasi kesesuaian nilai Homogeneity Index (HI) dan Conformity Index (CI) pada pasien kanker payudara pasca mastektomi yang menjalani radioterapi teknik IMRT. Penelitian dilakukan dengan menggunakan data 10 pasien post-mastektomi di Rumah Sakit TK II Pelamonia. Data dikumpulkan melalui analisis Dose Volume Histogram (DVH), yang mencakup dosis radiasi pada 98%, 50%, dan 2% dari volume target. Selain itu, dianalisis pula volume yang terpapar isodosis 95% serta persentase volume jantung yang menerima dosis 25 Gy. Data tersebut digunakan untuk menghitung nilai HI, CI, serta total dosis yang diterima oleh jantung. Hasil penelitian menunjukkan bahwa nilai HI berkisar antara 0,14-0,45, yang menunjukkan variasi tingkat keseragaman dosis. Sebagian besar pasien memiliki nilai CI di atas 0,9 dengan rentang 0,87-0,96, yang menandakan kesesuaian dosis yang baik dengan target volume tumor. Dosis jantung yang diterima oleh semua pasien berada di bawah batas toleransi yang ditetapkan oleh QUANTEC (V25<10%). Teknik IMRT efektif dalam meminimalkan dosis radiasi ke jantung dan mampu memberikan distribusi dosis yang sesuai dengan standar ICRU, dengan nilai HI dan CI yang mendekati optimal. Hasil ini menunjukkan bahwa IMRT merupakan metode yang efektif dalam terapi kanker payudara post mastektomi.
Identifikasi Struktur Geologi Kecamatan Jagoi Babang Dan Sekitarnya Di Kabupaten Bengkayang Menggunakan Data Gravitasi
Authors: Saputra Deni Alpito , Zulfian Zulfian , Perdhana Radhitya 
Published: November 2024

Panas bumi merupakan salah satu sumber daya alam yang terdapat di Kecamatan Jagoi Babang Kabupaten Bengkayang dan biasanya berkaitan dengan struktur geologi. Peneltian ini bertujuan untuk mengidentifikasi struktur geologi di Kecamatan Jagoi Babang dan sekitarnya di Kabupaten Bengkayang menggunakan metode gravitasi. Data yang digunakan untuk penelitian ini berupa data Free Air Anomaly (FAA) yang berasal dari Global Gravity Model Plus (GGMPlus). Data ini dikoreksi bouger dan terrain sehingga menghasilkan anomaly Bouger lengkap. Dari anomaly Bouger lengkap dilakukan pemisahan anomaly menggunakan metode kontinuasi ke atas. Anomaly regional daerah penelitian adalah 37,5 mGal hingga 46 mGal, sedangkan anomali residual sebesar -6 mGal hingga 8 mGal. Data anamali residual digunakan untuk pemodelan struktur bawah permukaan tanah dan analisis Second Vertical Derivative (SVD) sebanyak 2 lintasan. Berdasarkan pemodelan dan analisis SVD, lintasan A-A’ memiliki delapan (8) patahan dan lintasan B-B’ terdapat sebanyak enam (6) patahan. Patahan ini diduga menjadi jalur migrasi air panas hingga sampai ke permukaan tanah yang terdapat pada lintasan A-A’ dan lintasan B-B’. Dari penelitian ini diharapkan dapat menjadi referensi instansi terkait untuk mengambil kebijakan dan perencanaan pengembangan potensi panas bumi di Kecamatan Jagoi Babang Kabupeten Bengkayang.
Pengaruh Komposisi Bahan Baku Pada Kualitas Briket Berbahan Dasar Daun Matoa (Pometia pinnata) Menggunakan Perekat Organik
Authors: Asri Asifa , Shalihah Qariatus , Nugroho Bintoro Siswo 
Published: November 2024

Pemanfaatan bahan bakar fosil sebagai sumber utama energi terus mengalami peningkatan, namun ketersediaannya di alam cukup terbatas. Akibatnya, perlu ada upaya untuk mengurangi kebergantungan pada bahan bakar fosil, misalnya dengan menggunakan bahan bakar alternatif seperti briket. Pada penelitian ini, dilakukan pembuatan briket dari limbah daun matoa menggunakan dua jenis perekat alami, tepung terigu dan tepung tapioka. Komposisi bahan baku terhadap perekat divariasikan dengan perbandingan 50:50, 60:40, 70:30, 80:20, dan 90:10 untuk mengetahui kualitas briket dan pengaruhnya pada nilai kalor. Pabrikasi briket dilakukan dalam beberapa tahapan yaitu karbonisasi menggunakan oven, penghalusan dan pengayakan, pembuatan perekat, pencampuran bahan baku dengan perekat organik, pencetakan briket berbentuk balok berdimensi 3,4×3,4×3,2 cm3, dan pengeringan. Pengujian briket dilakukan dengan mengikuti Standar Nasional Indonesia (SNI) No. 01-6235-2000. Hasil yang diperoleh menunjukkan bahwa pengaruh jenis perekat organik, yaitu terigu dan tapioka, pada kualitas briket tidak terlihat secara signifikan. Namun, variasi komposisi bahan baku dan perekat menunjukkan adanya perbedaan pada kualitas briket. Variasi komposisi bahan baku terbaik pada eksperimen yaitu 80:20 (daun matoa:perekat organik) baik untuk perekat terigu maupun tapioka. Hasil pengujian briket untuk 80:20 (daun matoa:terigu) memiliki kadar air sebesar 6,03%, densitas 0,56 g/cm3, nilai kalor 4083,35 kal/g, laju pembakaran 0,16 g/min, kadar abu sebesar 5,60%, dan bagian yang hilang pada pemanasan 950°C sebesar 63,30%. Sedangkan, hasil pengujian briket 80:20 (daun matoa:tapioka) menghasilkan kadar air 5,23%, densitas 0,47 g/cm3, nilai kalor 4088,48 kal/g, laju pembakaran 0,15 g/min, kadar abu 6%, dan bagian yang hilang pada pemanasan 950 °C adalah 70,30%.
Bahasa Indonesia
Authors: Wibawa Putu Adrian Mahadi , Nudu Stephanus Rahardian Hersacra , Darwis Helena Angeline , Kirana I Putu Bintang Pradita 
Published: November 2024

ABSTRACT

Introduction: Traveler’s diarrhea is the common term used for diarrheas experienced by tourists during the trip or after they return to their respective hometowns. There are several factors of this disease, for instance, food and beverage hygiene, also differences in the normal flora.
Discussion: Most cases found are caused by foods and beverages contaminated by faeces with Eschericia coli. The disease itself is self-limiting, however, its clinical manifestation may cause inconvenience during the trip and interfere their vacation plans or other activities. Therefore, the knowledge of traveler’s diarrhea, which is mainly caused by Escherichia coli, is needed. The results showed that Escherichia coli is a rod-shaped, facultative anaerobe and gram-negative bacteria, which is the leading cause of traveler’s diarrhea. Its main clinical manifestation is diarrhea and may be accompanied by other symptoms, such as nausea, fever, abdominal cramps, vomiting and bleeding. Escherichia coli has a number of subtypes that cause a variety of symptoms. Out of the high incidence rate of traveler’s diarrhea caused by Escherichia coli, the subtype Enterotoxigenic Escherichia coli (ETEC) makes up 15% of the whole percentage. Watery diarrhea with no blood or fever became its classic manifestation. ETEC has 2 peptide groups, which are heat-stable toxin (ST) dan heat-labile toxin (LT) that interfere with water absorption inside the intestine, leading to diarrhea.
Conclusion: The main cause of traveler’s diarrhea is ETEC, whereas mild to heavy watery diarrhea is its common symptom. This review may be used as the foundation for further research and preventive actions.
Keywords: Traveler’s diarrhea, Diarrheagenic Escherichia coli, Subtypes of Escherichia coli, ETEC
Authors: Damar Sari Ni Made Bintang , Susilawati Luh Kadek Pande Ary 
Published: November 2024

ABSTRACT
Introduction: Working memory is one of the three components of executive function which has four components, namely central executive, phonological loop, visuospatial sketchpad, and episodic buffer. Many studies examining working memory in musicians and non-musicians have found that working memory performance in musicians outperforms non-musicians.
Discussion: Working memory has three components which each have a role in the activities carried out by the individual. Apart from that, working memory is also sensitive to various factors, one of which is musical training. Music training is considered to influence working memory and can have a positive impact on working memory abilities. The influence of musical training then results in differences in the performance of working memory in musicians when compared to non-musicians.
Conclusion: Working memory advantages have not been consistently found in every study comparing musicians and non-musicians. However, in general, the research results show that musicians have superior working memory performance compared to non-musicians. This can be caused by musical training factors and the diversity of musicians' excellence can be caused by differences in musical training.

Keywords: Working memory, Music Training, Musicians, Non-Musicians
Meningkatkan Potensi Terapeutik Kurkumin melalui Formulasi Nano Berbasis Eksosom untuk Fibrosis Paru Idiopatik
Authors: Anggarkusuma Mario Valentino , Yudiarta I Dewa Made Gede , Taqiyyaa Aisyah Lathifah 
Published: November 2024

Pendahuluan:
Idiopathic Pulmonary Fibrosis (IPF) merupakan penyakit paru kronis yang termasuk dalam kategori penyakit paru interstisial fibrosa kronis dengan penyebab yang tidak diketahui. Insiden ini meningkat seiring bertambahnya usia dan sering ditemukan pada laki-laki. Beberapa pengobatan yang ada saat ini, dapat mencegah terjadinya fibrosis namun belum dapat sepenuhnya menyembuhkan IPF. Oleh sebab itu, diperlukan kebutuhan untuk mengeksplorasi potensi bahan alami yang mudah didapat sebagai alternatif terapi. Salah satu bahan yang dimaksud adalah kurkumin yang terkandung dalam kunyit. Kurkumin yang terenkapsulasi eksosom akan meningkatkan efektivitas kurkimin sebagai pebobatan untuk IPF.
Pembahasan:
Idiopathic Pulmonary Fibrosis (IPF) terjadi apabila terdapat akumulasi jaringan parut yang ireversibel yang berkaitan dengan faktor genetik, epigenetik, dan lingkungan sehingga menyebabkan kerusakan sel epitel dan memicu aktivasi abnormal sel epitel. Sel epitel yang teraktivasi secara abnormal mengeluarkan TGF-?1 yang merupakan sitokin utama dalam fibrosis. Kurkumin bekerja dengan mengurangi ekspresi TGF-? yang mengatur deposisi matriks ekstraseluler, termasuk kolagen, dalam jaringan fibrotik, serta memblokir pelepasan TNF-?, Hydroxyproline (HYP), dan PDGF. Kurkumin yang terenkapsulasi eksosom akan dicerna lebih lambat serta meningkatkan stabilitas kurkumin di aliran darah. Selain itu, eksosom memiliki potensi untuk dikirim sebagai aerosol yang memiliki kemiripan dengan surfaktan paru-paru dan dapat diserap melalui lendir pernapasan.
Simpulan:
Pemanfaatan kurkumin melalui formulasi nano berbasis eksosom diharapkan dapat meningkatkan prognosis pada pasien IPF.
Authors: Maheswari Putu Ayu Dessita 
Published: November 2024

Introduction: The COVID-19 condition and the development of digital technology caused many daily activities changed to online activities, including learning activities. This can cause Computer Vision Syndrome (CVS) or Digital Eye Strain (DES). CVS is a collection of eye symptoms caused by digital screens.
Method: This research is a descriptive study with a cross-sectional study design with a proportion estimation formula to calculate the sample size. Data collection was carried out using Google Forms. Data processing uses the SPSS version 27 application
Result: There are 153 respondents. A total of 88 people (57.5%) experienced CVS, respondents who experienced CVS were dominated by female respondents 56 (63.6%), 59 people aged 21 years (67.0%), 47 people (53.4%) who used digital screens for > 6 hours, and 46 people who used glasses (52.3%). %). The most dominant symptoms were itchy eyes in 75 people (85.2%), sensitivity to light in 62 people (70.5%), and watery eyes in 66 people (75.0%).
Discussion: CVS occurs due to excessive use of digital screens and is influenced by various factors, such as gender, age, duration of digital screen use, use of glasses, contact lenses, break frequency, lighting, ergonomic position, etc.
Conclusion: Most students at PSSK FK Unud class of 2020 experienced CVS, especially women, aged 21 years, duration of use of digital screens > 6 hours, and used glasses. The most common symptoms are itchy eyes, sensitivity to light, and watery eyes.

Keywords: Computer Vision Syndrome (CVS), Digital Eye Strain (DES), College Students
CARDIAC REHABILITATION PROGRAM AS AN EFFORT TO IMPROVE THE QUALITY OF LIFE OF PATIENTS WITH CONgenital HEART DISEASE
Authors: Djuanda Louis Felix , Adiwati Erica Luis , Putri Putu Khrisna Arsawardani 
Published: November 2024

ABSTRACT

Introduction: Congenital Heart Disease (CHD) is the most common congenital disorder found throughout the world, including Indonesia. Currently, the main treatment for CHD patients is open cardiothoracic surgery. However, its implementation in Indonesia still has some obstacles due to several things which cause the life expectancy of CHD patients in Indonesia is estimated to be not as good as the life expectancy of CHD patients in developed countries. Apart from being related to life expectancy, CHD patients will also experience a decrease in their quality of life, especially those who are not treated properly. The cardiac rehabilitation program is one of the programs to overcome this.
Discussion: Cardiac rehabilitation program is able to improve physical and psychosocial quality and ensure that CHD patients' cognitive and socioemotional development is maintained. Cardiac rehabilitation includes physical exercise, psychosocial management, education, risk factor modification, and nutritional management. Several studies have shown that cardiac rehabilitation has many benefits and is safe for CHD patients. In its implementation, cardiac rehabilitation faces several challenges, especially in center-based cardiac rehabilitation (CBCR), so it is recommended to increase home-based cardiac rehabilitation (HBCR) while ensuring that information regarding HBCR is delivered completely and well received by the patients.
Conclusion: Based on this literature review, the authors suggest an increase in the implementation of cardiac rehabilitation for CHD patients throughout Indonesia, especially HBCR which can be carried out independently or in the community to improve the patient’s quality of life in the long term.

Keywords: congenital, cardiac, rehabilitation, quality of life
Clampeamento oportuno de cordão umbilical e os efeitos em longo prazo no recém-nascido e criança: papel do enfermeiro
Authors: Nascimento Luma da Silva , Molin Rossano Sartori Dal 
Published: November 2024

Objetivo: Identificar evidências na literatura sobre clampeamento oportuno do cordão umbilical para o RN/criança. Métodos: Revisão integrativa de literatura, com caráter analítico acerca dos benefícios da prática e o papel do enfermeiro. Foram realizadas etapas de amostragem, categorização e avaliação dos artigos, discussão e interpretação desses resultados. Utilizou-se artigos as bases da BVS e SCIELO publicados entre 2014 e 2024, disponíveis de forma gratuita e na íntegra. Por meio dos descritores: clampeamento do cordão umbilical, papel do enfermeiro nesta prática e efeito a longo prazo no RN/criança, associados aos operadores booleanos “AND” e “OR”. Os autores foram preservados, citados e referenciados. Por referir-se a uma revisão de literatura, dispensa-se a submissão do mesmo a aplicação do Comitê de Ética em Pesquisa. Resultados: Os principais achados foram localizados em: SCIELO (3 artigos) e BVS (2 artigos). Seguindo os critérios de inclusão e exclusão. Através disso, evidenciou-se o benefício da prática do tema, relacionada ao papel do enfermeiro. Considerações finais: Considera-se que ainda se faz necessário aprofundamento sobre o tema, tendo-se poucos artigos no conteúdo abordado. Cabe ao enfermeiro melhorar as ações de educação em saúde às equipes e famílias.
Características epidemiológicas do acidente vascular cerebral de pacientes atendidos em Altamira – Pará – Brasil, no período de 2009 a 2020
Authors: Chucre Ádria Cristina Araújo , Gonçalves Valmir Júnior Maia , Moraes Elison Sousa , Lopes Diogo Viana , Ferreira Denis Vieira Gomes , Granato Renan Rocha , Jacomel Bruna Grazielle Carvalho , Aarão Tinara Leila de Souza , Farias Ilka Lorena de Oliveira , Sousa Aline Andrade de 
Published: November 2024

Objetivo: Avaliar taxas relacionadas às internações e aos óbitos ocasionados pelo AVC (isquêmico e hemorrágico) em pacientes atendidos em Altamira/PA, entre janeiro de 2009 a dezembro de 2020. Métodos: Utilizando dados do Instituto Brasileiro de Geografia e Estatística (IBGE), do Sistema IBGE de Recuperação Automática (SIDRA) e do Departamento de informática do Sistema Único de Saúde (DATASUS/TABNET), registrados durante o período de janeiro de 2009 a dezembro de 2020, realizou-se cálculos de incidência, mortalidade e análise das séries temporais de internações e óbitos pelo teste de Mann-Kendall, para verificar padrões de tendência. Resultados: Após teste de Mann-Kendall, constatou-se: redução na tendência de internações (Z= -6,61); aumento na tendência do número de óbitos (Z= 3,42), repetida nos sexos masculino e feminino. Verificou-se tendência de redução de internações em indivíduos entre 30 a 39 (Z= -2); 50 a 79 anos (Z= <1,96); os indivíduos de 40 a 69 anos (Z> 1,96; p <0,05) apresentaram tendência de aumento de óbitos no período. Conclusão: Notou-se resultados divergentes em relação às estatísticas nacionais, levando à conclusão que se deve avaliar a forma de inserção de dados sobre AVC no DATASUS.
ДАЛЬНИЙ ВОСТОК – НОВЫЙ ВЕКТОР
Authors: А.А. КОЗЛОВ 
Published: November 2024

Статья посвящена приоритетным направлениям и проектам социальноэкономического развития Дальнего Востока и Арктики, реализация которых обеспечит опережающие темпы социальноэкономического развития региона. Раскрыты меры и механизмы, реализуемые в русле государственной политики Российской Федерации по ускоренному развитию Дальнего Востока.
The article is devoted to the priority directions and projects of the socioeconomic development of the Far East and the Arctic, the implementation of which will ensure the rapid pace of the socioeconomic development of the region. Th e measures and mechanisms implemented in line with the state policy of the Russian Federation on the accelerated development of the Far East are disclosed.
РЕСПУБЛИКА САХА(ЯКУТИЯ) 2032. СТРАТЕГИЧЕСКИЕ ПРИОРИТЕТЫ
Authors: М.А. ДАНИЛОВА 
Published: November 2024

В статье представлены основные направления социально экономического развития Республики Саха (Якутия) в долгосрочной перспективе. Обозначены приоритетные цели и основные задачи, стоящие перед республикой в сфере экономической и социальной политики.
The article presents the main directions of socioeconomic development of the Republic of Sakha (Yakutia) in the long term. Priorities and main tasks facing the republic in the field of economic and social policy are outlined.