bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Efficacy, Safety and Tolerability of a New Subcutaneous Immunoglobulin 16.5% (Octanorm [Cutaquig®]) in the Treatment of Patients With Primary Immunodeficiencies
Authors: Kobayashi Roger H. , Gupta Sudhir , Melamed Isaac , Mandujano J. Fernando , Kobayashi Ai Lan , Ritchie Bruce , Geng Bob , Atkinson Thomas Prescott , Rehman Syed , Turpel-Kantor Eva , Litzman Jiří 
Published: February 2019

Introduction: Subcutaneously administered immunoglobulin (SCIG) is increasingly used to treat patients with primary immunodeficiencies (PIDs). Octanorm (marketed as cutaquig® in USA and Canada) is a new 16.5% solution of human SCIG, manufactured by a process based on that of the intravenous preparation (IVIG) octagam®.Objectives: To investigate the efficacy, safety and tolerability of octanorm in a prospective, open-label, single-arm phase 3 study involving adult and pediatric patients with PIDs (NCT01888484; clinicaltrials.gov/ct2/show/NCT01888484).Methods: Patients who were previously treated with IVIG received a total of 64 weekly SCIG infusions, including 12 weekly infusions during the wash-in/wash-out period, followed by 52 weekly infusions during the evaluation period.Results: A total of 61 patients aged 2–73 years received 3,497 infusions of octanorm. The mean dose per patient was 0.175 g/kg/infusion. The mean calculated dose conversion factor from the patients' previous IVIG dose for octanorm was 1.37. No serious bacterial infections developed during the study. The rate of other infections per person-year during the primary observation period was 3.43 (upper 95% CI 4.57). All but one non-bacterial infection were mild or moderate in intensity. IgG trough levels were constant during the course of the study. Eleven patients (18.0%) experienced 14 mild or moderate systemic adverse events (AEs) related to octanorm. The rate of related AEs per infusion was 0.004. In 76.7% of infusions, no infusion site reactions were observed and only two (0.3%) reactions were deemed severe. The incidence of site reactions decreased with successive infusions.Conclusion: The new 16.5% SCIG octanorm was shown to be efficacious in preventing infections in PIDs, and was well tolerated.
Spectroscopic Orbits of Subsystems in Multiple Stars. V.
Authors: Tokovinin Andrei 
Published: February 2019

Abstract
Spectroscopic orbits are determined for inner subsystems in nine stellar hierarchies (HIP 2863, 4974, 8353, 28796, 35261, 92929, 115272, 115552, and 117596). Their periods range from 2.5 to 312 days. For each system, estimates of masses, orbital inclination, and other parameters are given.
Near-infrared Survey and Photometric Redshifts in the Extended GOODS-North Field
Authors: Hsu Li-Ting , Lin Lihwai , Dickinson Mark , Yan Haojing , Bau-Ching Hsieh , Wang Wei-Hao , Lee Chien-Hsiu , Yan Chi-Hung , Scott Douglas , Willner S. P. , Ouchi Masami , Ashby Matthew L. N. , Chen Yi-Wen , Daddi Emanuele , Elbaz David , Fazio Giovanni G. , Foucaud Sebastien , Huang Jiasheng , Koo David C. , Morrison Glenn , Owen Frazer , Pannella Maurilio , Pope Alexendra , Simard Luc , Wang Shiang-Yu 
Published: February 2019

Abstract
We present deep J- and H-band images in the extended Great Observatories Origins Deep Survey-North field covering an area of 0.22 deg2. The observations were taken using WIRCam on the 3.6 m Canada–France–Hawaii Telescope. Together with the reprocessed K
s-band image, the 5σ limiting AB magnitudes (in 2″ diameter apertures) are 24.7, 24.2, and 24.4 AB mag in the J, H, and K
s bands, respectively. We also release a multiband photometry and photometric redshift catalog containing 93,598 sources. For non-X-ray sources, we obtained a photometric redshift accuracy σ
NMAD = 0.036 with an outlier fraction η = 7.3%. For X-ray sources, which are mainly active galactic nuclei (AGNs), we cross-matched our catalog with the updated 2M-CDFN X-ray catalog from Xue et al. and found that 658 out of 683 X-ray sources have counterparts. GALEX UV data are included in the photometric redshift computation for the X-ray sources to give σ
NMAD = 0.040 with η = 10.5%. Our approach yields more accurate photometric redshift estimates compared to previous works in this field. In particular, by adopting AGN–galaxy hybrid templates, our approach delivers photometric redshifts for the X-ray counterparts with fewer outliers compared to the 3D-Hubble Space Telescope catalog, which fit these sources with galaxy-only templates.
Searching for the Donor Stars of ULX Pulsars
Authors: Heida M. , Harrison F. A. , Brightman M. , Fürst F. , Stern D. , Walton D. J. 
Published: February 2019

Abstract
We report on our search for the optical counterparts of two ultraluminous X-ray pulsars with known orbital periods, M82 X-2 and NGC 5907 X-1, in new and archival Hubble Space Telescope observations, in an effort to characterize the donor stars in these systems. We detect five near-infrared sources consistent with the position of M82 X-2 that are too bright to be single stars. We also detect seven sources in the WFC3/UVIS F336W image whose photometry matches that of 10–15 M
⊙ stars turning off the main sequence. Such stars have densities consistent with the properties of the donor star of M82 X-2 as inferred from X-ray timing analysis, although it is also possible that the donor is a lower-mass star below our detection limit or that there is a significant contribution from the accretion disk to the optical emission. We detect three candidate counterparts to NGC 5907 X-1 in the near-infrared. All of these are too bright to be the donor star of the ultraluminous X-ray source (ULX), which, based on its orbital period, is a red giant. The high background at the location of NGC 5907 X-1 precludes us from detecting this expected donor star. The recently discovered NGC 5907 ULX-2 also falls within the field of view of the near-infrared imaging; we detect four sources in the error circle, with photometry that matches asymptotic giant branch stars. The star suggested to be the counterpart of NGC 5907 ULX-2 by Pintore et al. falls outside our 2σ error circle.
On the Existence of Brown Dwarfs More Massive than the Hydrogen Burning Limit
Authors: Forbes John C. , Loeb Abraham 
Published: February 2019

Abstract
Almost by definition brown dwarfs are objects with masses below the hydrogen burning limit, around 0.07 M
⊙. Below this mass, objects never reach a steady state where they can fuse hydrogen. Here we demonstrate, in contrast to this traditional view, that brown dwarfs with masses greater than the hydrogen burning limit may in principle exist in the universe. These objects, which we term “overmassive brown dwarfs,” form a continuous sequence with traditional brown dwarfs in any property (mass, effective temperature, radius, and luminosity). To form an overmassive brown dwarf, mass must be added sufficiently slowly to a sufficiently old traditional brown dwarf below the hydrogen burning limit. We identify mass transfer in binary brown dwarf systems via Roche lobe overflow driven by gravitational waves to be the most plausible mechanism to produce the bulk of the putative overmassive brown dwarf population.
The Origin and Early Evolution of a Bipolar Magnetic Region in the Solar Photosphere
Authors: Getling A. V. , Buchnev A. A. 
Published: February 2019

Abstract
Finding the formation mechanisms for bipolar configurations of a strong local magnetic field under control of the relatively weak global magnetic field of the Sun is a key problem of the physics of solar activity. This study is aimed at discriminating whether the magnetic field or fluid motion plays a primary, active role in this process. The very origin and early development stage of Active Region 12548 are investigated based on Solar Dynamics Observatory/Helioseismic and Magnetic Imager observations of 2016 May 20–25. Full-vector magnetic and velocity fields are analyzed in parallel. The leading and trailing magnetic polarities are found to grow asymmetrically in terms of their amplitude, magnetic flux, and the time variation of these quantities. The leading-polarity magnetic element originates as a compact feature against the background of a distributed trailing-polarity field, with an already existing trailing-polarity magnetic element. No signs of strong horizontal magnetic fields are detected between the two magnetic poles. No predominant upflow between their future locations precedes the origin of this bipolar magnetic region (BMR); instead, upflows and downflows are mixed, with some prevalence of downflows. Any signs of a large-scale horizontal divergent flow from the area where the BMR develops are missing; in contrast, a normal supergranulation and mesogranulation pattern is preserved. This scenario of early BMR evolution is in strong contradiction with the expectations based on the model of a rising Ω-shaped loop of a flux tube of strong magnetic field, and an in situ mechanism of magnetic-field amplification and structuring should operate in this case.
EQUITABLE ADAPTATION PLANNING IN HISTORIC COASTAL CITIES: OBSERVATIONS FROM AN ARCHITECTURAL PRACTICE
Authors: Zurek Stephanie Reed 
Published: February 2019

INTRODUCTION In communities all along the seaboard, we have large and challenging conversations ahead of us. Historic coastal cities must reconcile tensions between preserving a community's existing cultural heritage and the reality of planning for several feet of sea level rise in the coming decades. As more frequent tidal flooding and more extensive storm surges begin to affect the lowest-lying neighborhoods, cities and states are faced with decisions about where and when to invest in adaptation measures and at what scale. Adaptation measures will undoubtedly change the landscape of the existing built environment, which contributes to each community's cultural heritage and its collective psyche. How can a community move forward with the joint goals of preservation and protection? The decisions are daunting and imagining a built environment that accommodates a rising sea can be a surreal exercise. Questions will be raised such as, what funds are available for large-scale infrastructure projects? Or, why is investment continuing in this neighborhood if it will be under water in fifty years? Architects may feel unequipped to enter these conversations. The easiest, and likely last, series of decisions in this process may be about how to elevate a building. However, before arriving at such a decision, an interconnected web of related conversations must occur. Despite one's reluctance to participate in such a daunting task, a designer's skill set is useful in the process. The assistance that is required of architects at the front end of preparing historic coastal communities for sea level rise includes gathering and presenting existing conditions data, facilitating robust and inclusive conversations, educating decision-makers, and illustrating options, all of which empower communities to work together toward an appropriate and equitable solution. Architects have an opportunity to not only facilitate and participate in adaptation planning conversations, but also to advocate for and influence the structure of decision-making processes to be more inclusive and participatory. The following discussion highlights specific challenges in historic coastal cities, using several examples from our work in Rhode Island, as well as observations of state and municipal planning processes. As architects and urban designers, it is Union Studio's mission to enrich the lives of people and communities through the design of buildings and places for this generation and the next. We dedicate ourselves to projects ranging from large-scale neighborhood masterplans and public libraries to smaller-scale urban infill development and residential design. The change in scale from one project to the next compels us to consider the implications of small-scale design details on the overall character of a place and, conversely, the implications of broad regulatory policies on the design of a single building or home.
Utilisation d’un adhésif à polymérisation UV pour combler les surfaces lacunaires d’objets d’art en verre ou à revêtements vitreux
Authors: Bechoux Viviane , Fouquet Thierry , Verge Pierre , Bomfim Joao A. S. 
Published: February 2019

Cette recherche propose une méthode de réintégration de perte de matière du verre et d’émaux sur supports céramiques et métalliques.Elle vise à remplacer les résines époxydiques, teintées dans la masse utilisées comme matériau de comblement, par une résine polymérisable aux UV, colorée à l’aide de poudres de verre.
Autour d’un Outrenoir de Pierre Soulages
Authors: Grandière Pauline Hélou-de la , Meunier Amandine 
Published: February 2019

Les collaborations en conservation-restauration sont fréquentes, mais s’organisent la plupart du temps de façon empirique : une méthodologie est proposée ici, reprenant les outils utilisés en médecine et en management. L’article donne l’occasion de revenir sur cette expérience exemplaire du point de vue de la nécessaire coordination et de la collaboration pluridisciplinaire.
L’Antiphonaire d’Oosteeklo et son enlumineur (Cornelia van Wulfschkercke ?)
Authors: Vanwijnsberghe Dominique 
Published: February 2019

L’Antiphonaire d’Oosteeklo, conservé à la bibliothèque du Musée des Beaux-Arts de Gand, a peu retenu l’attention des historiens d’art, en dépit de son importance pour l’histoire de l’enluminure flamande. Un remarquable colophon révèle l’identité de sa commanditaire, Quentine de Mastaing, abbesse des cisterciennes d’Oosteeklo ; il donne le nom de deux copistes et l’année de réalisation du manuscrit (1498). Ses scènes historiées aussi peuvent être rattachées à une enlumineresse documentée : la fameuse Cornelia van Wulfschkercke, carmélite de Sion à Bruges, à qui un œuvre assez important a pu être donné. Cette nouvelle attribution est l’occasion de présenter deux autres manuscrits peints par la même main et d’examiner la validité d’une identification qui reste, à ce stade des recherches, une hypothèse de travail.
La Chute d’Icare des Musées royaux des Beaux-Arts de Belgique réattribuée par l'examen de laboratoire
Authors: Kockaert Léopold 
Published: February 2019

La controverse sur l'attribution de « La Chute d'Icare » des Musées Royaux des Beaux-Arts de Bruxelles a été alimentée a plusieurs reprises, notamment par une datation au radiocarbone de la première toile dont il ressort que P. Bruegel l'Ancien ne peut pas en être l'auteur ; et plus récemment par la publication d'un livre de D. Allart et C. Currie, ainsi que d'un article de ces mêmes auteures publié dans ces pages. Il me semble que la désattribution de cette œuvre n'est pas compatible avec certains résultats d'examen de laboratoire publiés dans la littérature. Dès lors, je propose de passer en revue les différentes études qui ont été menées sur cette œuvre et de dégager une conclusion qui se base sur leur ensemble. Prenant en compte l'analyse d'un échantillon de la peinture, je donnerai en particulier une interprétation des réflectogrammes du dessin sous-jacent qui tient compte d'une probable transposition. Je montrerai enfin comment les différents examens convergent vers la conclusion que « La Chute d'Icare » des Musées Royaux des Beaux-Arts est vraisemblablement un panneau authentique de P. Bruegel, père ou fils, qui a été fortement dénaturé par la transposition sur toile.
The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals
Authors: Batista Nathália V. , Barbagallo Marialuisa , Oliveira Vivian L. S. , Castro-Gomes Thiago , Oliveira Rene D. R. , Louzada-Junior Paulo , Pinheiro Geraldo R. C. , Mantovani Alberto , Teixeira Mauro M. , Garlanda Cecilia , Amaral Flávio A. 
Published: February 2019

Abstract
The purpose of this study was to investigate the role of pentraxin 3 (PTX3), a pivotal component of the innate immune system, in gout. Levels of PTX3 and IL-1β in human samples were evaluated by ELISA. Development of murine gout was evaluated through the levels of cytokines (PTX3, CXCL1, and IL-1β) and neutrophil recruitment into the joint cavity. Phagocytosis of monosodium urate (MSU) crystals and caspase-1 activation were determined by flow cytometer. Acute gout patients showed elevated concentration of PTX3 in plasma and synovial fluid as compared with healthy and osteoarthritic subjects. Moreover, there was a positive correlation between intra-articular PTX3 and IL-1β levels. PTX3 was induced in the periarticular tissue of mice postinjection of MSU crystals. Importantly, Ptx3-deficient mice showed reduced inflammation in response to MSU crystal injection compared with wild-type mice, including reduction of neutrophil recruitment into the joint cavity and IL-1β and CXCL1 production. Interestingly, addition of PTX3 in vitro enhanced MSU crystal phagocytosis by monocytes and resulted in higher production of IL-1β by macrophages. This contribution of PTX3 to the phagocytosis of MSU crystals and consequent production of IL-1β occurred through a mechanism mainly dependent on FcγRIII. Thus, our results suggest that PTX3 acts as a humoral pattern recognition molecule in gout facilitating MSU crystal phagocytosis and contributing to the pathogenesis of gouty arthritis.
IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection
Authors: O’Brien Carleigh A. , Batista Samantha J. , Still Katherine M. , Harris Tajie H. 
Published: February 2019

Abstract
Control of chronic CNS infection with the parasite Toxoplasma gondii requires ongoing T cell responses in the brain. Immunosuppressive cytokines are also important for preventing lethal immunopathology during chronic infection. To explore the loss of suppressive cytokines exclusively during the chronic phase of infection, we blocked IL-10R in chronically infected mice. Consistent with previous reports, IL-10R blockade led to severe, fatal tissue destruction associated with widespread changes in the inflammatory response, including increased APC activation, expansion of CD4+ T cells, and neutrophil recruitment to the brain. We then sought to identify regulatory mechanisms contributing to IL-10 production, focusing on ICOS, a molecule implicated in IL-10 production. Unexpectedly, ICOS ligand (ICOSL) blockade led to a local expansion of effector T cells in the brain without affecting IL-10 production or APC activation. Instead, we found that ICOSL blockade led to changes in T cells associated with their proliferation and survival. We observed increased expression of IL-2–associated signaling molecules CD25, STAT5 phosphorylation, Ki67, and Bcl-2 in T cells in the brain, along with decreased apoptosis. Interestingly, increases in CD25 and Bcl-2 were not observed following IL-10R blockade. Also, unlike IL-10R blockade, ICOSL blockade led to an expansion of both CD8+ and CD4+ T cells in the brain, with no expansion of peripheral T cells or neutrophil recruitment to the brain and no severe tissue destruction. Overall, these results suggest that IL-10 and ICOS differentially regulate T cell responses in the brain during chronic T. gondii infection.
Relation of Color Doppler Twinkling Artifact and Scale or Pulse Repetition Frequency
Authors: Bacha Raham , Gilani Syed Amir , Manzoor Iqra 
Published: February 2019

Objective:
The aim of this study is to determine the effect of scale/pulse repetition frequency (PRF) on the appearance of color Doppler twinkling artifact.

Materials and Methods:
We commenced this cross-sectional study for 20 months from November 2014 to July 2016. During routine ultrasound examination, we observed multiple case of twinkling artifact produced by renal stones, calcifications in the thyroid nodules, bony fragments and intestinal gases, etc., We observed twinkling artifact with low- and high-PRF settings in 500 different structures. A total of 500 other structures were included wherein there was no Doppler twinkling artifact produced by them, with usual optimum PRF settings. These structures were also evaluated with low- and high-PRF to determine the effect of PRF on twinkling artifact effectively. All the patients were examined according to the AIUM guideline for appropriate examination protocol. Data were collected from the observation of twinkling artifact with low- and high-PRF/scale and evaluated with the help of IBM SPSS 24 package, the results were summarized as follow.

Results:
Change in scale/PRF could not affect the twinkling artifact. The twinkling artifact observed with low-PRF was the same as seen with high-PRF. There was a significant agreement between low- and high-PRF in the production of color twinkling artifact. The kappa value of agreement was estimated as 0.96, whereas the Pearson's correlation was significant with the value of 0.001. Same twinkling artifact was created with low- and high-PRF, with no significant variation.

Conclusion:
Twinkling artifact is independent of PRF/Scale.
The Greek crisis: a story of self-reinforcing feedback mechanisms
Authors: Juselius Katarina , Dimelis Sophia 
Published: February 2019

AbstractWhile there seems to be a well-established consensus about the underlying causes to the Greek crisis, less is known about internal and external transmission mechanisms that ultimately caused unemployment to increase rapidly over this period. Motivated by the structural slumps theory in Phelps (Structural slumps,1994), the paper attempts, therefore, to uncover the dynamic mechanisms behind prices, interest rates, and external imbalances that contributed to the severity and the length of the crisis. The authors find that the strongly increasing real bond rate and unemployment rate together with an persistently appreciating real exchange rate and a deterioration of competitiveness in the eurozone have contributed to persistently growing structural imbalances in the Greek economy. As the lack of confidence in the Greek economy grew steadily, the scene was set for a monumental structural slump. Over the crisis period, all variables exhibited self-reinforcing feedback adjustment somewhere in the system except for inflation rate. Unemployment took the burden of adjustment when the bond rate sky rocketed, competitiveness deteriorated, and confidence fell.
Martyrdom and Mapuche Metal: Defying Cultural and Territorial Reductions in Twenty-First-Century Wallmapu
Authors: Rekedal Jacob 
Published: February 2019

AbstractSeventeen-year-old Alex Lemún was shot in 2002 while retaking ancestral lands for his people, the Mapuche, on the western side of the Andes in the Southern Cone. The song “Weichafe Alex Lemún” by the band Pewmayén memorialized Lemún as a weichafe (warrior) and helped spark a new musical movement. Pewmayén’s fusion of ritual sounds with heavy metal both valorized traditional expressions and opened sociocultural boundaries that historically isolated those expressions from non-Mapuche society. Musical analysis and ethnographic description demonstrate how Mapuche music is opening new territories of sound and meaning, with serious implications for indigenous empowerment and cultural continuity.Alex Lemún fue disparado en 2002, con diecisiete años de edad, mientras participaba en una toma de tierras ancestrales por parte de su pueblo, los Mapuche, al lado oeste de los Andes en el Cono Sur. La canción “Weichafe Alex Lemún” del grupo Pewmayén honró a Lemún como un weichafe (guerrero) y ayudó a iniciar un nuevo movimiento musical. La fusión llevada a cabo por Pewmayén, de los sonidos rituales con la música metal, valorizó las expresiones tradicionales y abrió los bordes socioculturales que históricamente aislaban tales expresiones de la sociedad mestiza adyacente. Análisis musical y descripción etnográfica demuestran cómo la música mapuche está abriendo nuevos territorios de sonido y significado, con implicaciones serias para el empoderamiento y la continuidad cultural de pueblos originarios.