bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep Disturbance in Vestibular Migraine and Meniere's Disease: A Comparative Analysis
Authors: Yang Chao‐Hui , Tsai Ming‐Hsien , Hwang Chung‐Feng , Yang Ming‐Yu 
Published: November 2024

AbstractObjectiveTo investigate the differences in the prevalence of sleep disturbance between vestibular migraine (VM) and Meniere's disease (MD), and to determine whether poor sleep quality is correlated with dizziness handicap.Study DesignObservational prospective study.SettingTertiary Academic Medical Center.MethodsPatients diagnosed with VM, MD, and healthy controls completed the Mini Sleep Questionnaire (MSQ), which comprises 10 items assessing sleep quality. The MSQ total score was calculated by summing the scores of each item. The Dizziness Handicap Inventory (DHI) was used to evaluate the physical, emotional, and functional impacts of dizziness on daily life.ResultsA total of 87 participants (35 with VM, 39 with MD, and 13 healthy controls) were enrolled. Both the VM and MD groups had significantly higher MSQ total scores than the control group (P < .001). The VM group exhibited a higher prevalence of “difficulty falling asleep” (P = .015) and “headaches on awakening” (P = .012) than the MD group. Additionally, the MSQ total score was significantly correlated with the DHI total score in VM patients (P = .001, r = .518). VM patients with severe dizziness handicap had significantly higher MSQ total scores than those with mild handicap (P = .005).ConclusionThis study highlights the high prevalence of sleep disturbance in both VM and MD patients. The severity of sleep disturbance is correlated with dizziness handicap in VM patients, emphasizing the importance of assessing sleep quality and promoting good sleep habits in the management of VM.
Oral frailty and its association with systemic health: A narrative review
Authors: Watanabe Yutaka , Matsuda Nami , Miura Kazuhito , Ohara Yuki , Iwasaki Masanori , Hirano Hirohiko , Ikebe Kazunori , Iijima Katsuya , Kono Yukari , Yamazaki Yutaka 
Published: November 2024

AbstractThis narrative review examined whether six measures of oral frailty (number of teeth present, chewing ability, articulatory oral motor skills, tongue pressure, difficulty in eating tough foods, and difficulty in swallowing fluids) were associated with an improvement in general health problems in older adults and whether interventions for oral functional decline would improve their general health status. We included longitudinal and intervention studies focusing on these six oral frailty parameters published between 2017 and 2020 in PubMed. The National Institutes of Health Quality Assessment Toolkit for Quantitative Research was used to assess methodological quality. Twenty‐five longitudinal and four intervention studies met the eligibility criteria. Among the longitudinal studies, oral frailty (defined as the applicability of three or more of the six parameters) was associated with physical frailty, sarcopenia, need for nursing care, death, nutritional status, and home status; chewing and bite strength were associated with frailty and death; and dysphagia was associated with death. The intervention studies showed that five of the six oral frailty parameters could be improved, except the number of teeth. Further studies must be conducted on treatment methods to promote functional recovery in these five parameters and evaluate their relationship with the general health status.
Proposing Novel Biological Scaffolds for the Regeneration of the Dura Mater
Authors: Monazah Mohammad Mehdi , Alimohammadi Ehsan , Rostaminasab Gelavizh , Zarrintaj Payam , Rezakhani Leila 
Published: November 2024

ABSTRACTThe dura mater protects underlying tissues and cerebrospinal fluid, but dural abnormalities can cause leaking and meningitis and wound infections. This review emphasizes the relevance of dural repair and the progress of dural reconstruction materials, focusing on biological scaffolds. A comprehensive assessment of dural substitution literature focused on composite, acellular, natural, synthetic, and homologous materials. Decellularized dura scaffolds as viable natural biomaterials for tissue engineering are explored in this overview of these materials' properties, effectiveness, and therapeutic uses. The evaluation also compares materials and assesses host tissue response in preclinical and clinical studies. The review highlights various dural substitution findings. There is no gold standard for dural repair, despite the variety of materials used. Replicating natural dura mater's mechanical and structural qualities is difficult. Recent research suggests that decellularized dura scaffolds can regenerate tissue while reducing inflammation and transplant rejection. Furthermore, the movement toward personalized medicine in this sector suggests that bespoke alternatives might be chosen depending on patient characteristics, improving treatment effects. Synthesizing dural replacement research and clinical uses in this review adds to knowledge. It tackles standard materials' shortcomings and shows how biological scaffolds might improve dural repair. The analysis opens the door to personalized dural repair research that might enhance patient outcomes and advance neurosurgery. The insights presented herein highlight the intriguing prospects for appropriate dural restorative materials, seeking to improve dural defect treatment.
Investigation on piezoresistive properties of reduced graphene oxide treated glass textiles based multifunctional sensors
Authors: Singh Sudhanshu , Kamble Zunjarrao , Neje Ghanshyam 
Published: November 2024

AbstractGlass fabric‐reinforced composites (GFRC) and other revolutionary engineered materials find extensive application in the aerospace, construction, and automobile sectors. It is challenging to predict damage under real‐time stresses due to the anisotropic behavior of composite materials. This study presents the development of a glass textile‐based multifunctional composite sensor and demonstrates its application as a change in resistance or gauge factor in structural health monitoring (SHM) systems. This sensor is coated with reduced graphene oxide (rGO) nanomaterial. Its electrical resistance is evaluated by examining the concentration of nanoparticles and varying geometrical parameters. A three‐point bending method assessed the piezoresistive behavior of the integrated sensor in the GFRC. The impact of sensor width and relative placements in the material's thickness direction within the composite samples is evaluated. Cyclic flexural testing was also performed to demonstrate real‐world applications. The research concludes that it can be utilized as a damage assessment technique for GFRC. The developed sensor can be used to provide an electrically conductive path or as a resistor in the field of E‐textiles. The developed piezoresistive sensor has the flexibility to be used as a multifunctional sensor for multiple purposes, such as force, torque, weight, pressure, flow, acceleration sensors, etc.Highlights
Glass textile‐based multifunctional materials are reported as strain‐monitoring sensors.
Tailored sensor resistance could be achieved through rGO current conduction paths.
Glass textile‐based sensors could potentially be used in the field of E‐textile.
Study on the Mechanism of Raspberry (Rubi fructus) in Treating Type 2 Diabetes Based on UPLC‐Q‐Exactive Orbitrap MS, Network Pharmacology, and Experimental Validation
Authors: Wang Xiaoge , Zhang Xueyan , Liao Qiyuan , Rui Xuelin , Wang Rui 
Published: November 2024

ABSTRACTAimThe aim of this study is to analyze the chemical composition of raspberry using liquid chromatography‐mass spectrometry (LC–MS) technology, predict the potential effects of raspberry in treating type 2 diabetes through network pharmacology, and conduct preliminary validation through in vitro experiments.MethodsA Waters CORTECS C18 column (3.0 mm × 100 mm, 2.7 μm) was used; mobile phase A consisted of 0.1% formic acid in water and mobile phase B consisted of 0.1% formic acid in acetonitrile. Gradient elution was performed with full‐scan mode in both positive and negative ion modes, covering a mass range of m/z 100–1500. The chemical components of raspberry were analyzed and identified based on secondary spectra from databases and relevant literature. The disease targets related to type 2 diabetes were searched, and protein–protein interaction network analysis as well as gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were conducted on the intersecting targets of the active components of raspberry and the disease. HepG2 cells were used for experimental validation, with high glucose‐induced insulin resistance models established. The CCK‐8 method was employed to assess the effects of raspberry on cell proliferation, while Western blotting was used to measure the expression of proteins related to the AGE/RAGE signaling pathway.ResultsA total of 47 components were identified, including 10 organic acids, 15 flavonoids, 12 phenols, 2 alkaloids, 4 terpenoids, 1 miscellaneous compound, 1 stilbene, 1 steroid and its derivatives, and 1 diterpenoid. Through database screening, seven active components were identified: kaempferol, epicatechin, ellagic acid, crocetin, stigmasterol, fisetin, and isorhamnetin. KEGG and GO results indicated that the therapeutic effects of raspberry on type 2 diabetes may be related to the advanced glycation end product (AGE)– receptor for advanced glycation end product (RAGE) signaling pathway. Establishment of an insulin resistance model in HepG2 cells demonstrated that, compared to the control group, the raspberry treatment group upregulated p53 protein expression while downregulating the expression of RAGE, Akt1, and Caspase‐3 proteins.ConclusionThis study preliminarily elucidates that the therapeutic effects of raspberry in treating type 2 diabetes may be mediated through the inhibition of the AGE–RAGE signaling pathway, providing important references for the study of the pharmacological basis and clinical application of raspberry.
Chondroitin sulfate in invertebrate development
Authors: Moriya Ayano , Nakato Eriko , Li Jin‐Ping , Nakato Hiroshi 
Published: November 2024

AbstractChondroitin sulfate (CS) is one of the most evolutionarily conserved glycosaminoglycans (GAGs). Although CS's function in skeletal development is well established in vertebrates, CS exists in more primitive animal species with no cartilage or bone, such as C. elegans and Drosophila, indicating that the original role of CS was not in the skeletal system. In this review, we focus on the roles of CS and the mechanisms of action during development of two genetically trackable model organisms, C. elegans and Drosophila.
Bayesian Safety and Futility Monitoring in Phase II Trials Using One Utility‐Based Rule
Authors: Lee Juhee , Thall Peter F. 
Published: November 2024

ABSTRACTFor phase II clinical trials that determine the acceptability of an experimental treatment based on ordinal toxicity and ordinal response, most monitoring methods require each ordinal outcome to be dichotomized using a selected cut‐point. This allows two early stopping rules to be constructed that compare marginal probabilities of toxicity and response to respective upper and lower limits. Important problems with this approach are loss of information due to dichotomization, dependence of treatment acceptability decisions on precisely how each ordinal variable is dichotomized, and ignoring association between the two outcomes. To address these problems, we propose a new Bayesian method, which we call U‐Bayes, that exploits elicited numerical utilities of the joint ordinal outcomes to construct one early stopping rule that compares the mean utility to a lower limit. U‐Bayes avoids the problems noted above by using the entire joint distribution of the ordinal outcomes, and not dichotomizing the outcomes. A step‐by‐step algorithm is provided for constructing a U‐Bayes rule based on elicited utilities and elicited limits on marginal outcome probabilities. A simulation study shows that U‐Bayes greatly improves the probability of determining treatment acceptability compared to conventional designs that use two monitoring rules based on marginal probabilities.
Role of Sulfur in Enhancing UV‐Light Absorption and Photoelectrochemical Performance of ZnO/N,S‐doped CQDs Nanocomposite
Authors: Giasari Afifah Salma , Pratama Rifky Adhia , Eddy Diana Rakhmawaty , Irkham  , Adzani Muchammad Dhuhri , Fransisca Natasha , Pratomo Uji , Gultom Noto Susanto , Indriyati  , Primadona Indah 
Published: November 2024

AbstractThe modification of ZnO, such as transforming it from 1‐D to 3‐D nanostructures or compositing it with carbon‐based materials, has been extensively explored to enhance light energy harvesting and reduce electron‐hole recombination‐key limitations of ZnO. Herein, the effect of different composite materials, specifically nitrogen‐doped carbon quantum dots (N‐CQDs) and nitrogen, sulfur‐doped carbon quantum dots (N,S‐CQDs), on ZnO's morphology and photocurrent response was studied. Various morphologies were synthesized on conductive glass substrate using a one‐pot hydrothermal method, including flower‐like structure for ZnO/N‐CQDs (∼d = 0.9 µm) and multilayered microspheres for ZnO/N,S‐CQDs (∼d = 1.1 µm). The inclusion of sulfur atoms in the composite resulted in a reduced bandgap value from 3.22 to 3.11 eV, along with enhanced light absorption efficiency and improved separation of photogenerated electron‐hole pairs. Furthermore, the crystallinity of ZnO/N,S‐CQDs was significantly enhanced compared to ZnO without sulfur doping. These improvements were reflected in the photoelectrochemical (PEC) measurements, where ZnO/N,S‐CQDs showed a current density of 21.8 µA/cm2 at 0.5 V (vs. Ag/AgCl), which is 5.5 times higher than that of ZnO/N‐CQDs (4.0 µA/cm2). These findings demonstrate that sulfur doping improves photocatalytic efficiency, making 3D ZnO/N,S‐CQDs a promising candidate for various UV‐driven PEC applications.
Synthesis and Characterization of Chitosan–Silver Nanocomposite Film: Antibacterial and Cytotoxicity Study
Authors: Ogungbesan Shephrah Olubusola , Buxaderas Eduardo , Adedokun Rosemary Anwuli , Moglie Yanina , Grijalvo Santiago , García María Teresa , Bingbing Cui , Díaz Díaz David , Fu Guodong 
Published: November 2024

AbstractThis study is aimed at the in situ preparation and antibacterial study of silver nanoparticles within the matrix of an eco‐friendly, biocompatible, biodegradable, and bioavailable biopolymer (chitosan) to form Chi–AgNP film via multiple noncovalent interactions between the organic polymer and the nanoparticles. The film is fully characterized by infrared and ultraviolet spectroscopy, scanning electron microscopy, transmission electron microscopy, X‐ray photoelectron spectroscopy, and thermogravimetric analysis. The characterization confirms the successful incorporation of silver nanoparticles into the polymeric network. Infrared spectroscopy reveals peaks corresponding to the vibration of functional groups present in chitosan with enhanced intensity and blueshifts caused by the presence of silver nanoparticles. Well‐monodispersed spherical silver nanoparticles with an average size of 10 nm are observed in the Chi–AgNP film. The surface plasmon resonance at 447 nm is consistent with a typical silver plasmon. Furthermore, the antibacterial effects on E. coli and S. aureus were determined and attributed to the release of AgNPs observed by UV absorption.
A Single‐Atom Mn/MoO3−x Nanoagonist for Cascade cGAS/STING Activation in Tumor‐Specific Catalytic Metalloimmunotherapy
Authors: Hu Xi , Ma Zhiyuan , Zhang Bo , Wang Jie , Zhou Yan , Li Jun , Liu Tianqi , Zhang Jingxin , Hong Bangzhen , Zhu Mingjian , Li Fangyuan , Ling Daishun 
Published: November 2024

AbstractThe cyclic GMP‐AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway plays a crucial role in initiating anti‐tumor immunity. Despite the development of various STING agonists, their effectiveness is often limited by suboptimal activation efficiency and poor sustainability. To address this, a Mn/MoO3−x nanoagonist featuring Mn single‐atom sites is presented, designed for cascade cGAS/STING activation in tumor‐specific catalytic metalloimmunotherapy. The single‐atom nanoagonist (SANA) is meticulously crafted by doping Mn atoms into defective molybdenum oxide (MoO3−x), enabling robust peroxidase‐mimicking catalysis and inducing severe double‐stranded DNA (dsDNA) damage in tumors. Of note, Mn2+ and MoO42− can be responsively released from Mn/MoO3−x SANA and enhance the sensitivity of cGAS to dsDNA. Importantly, MoO42− with a relatively slow‐release profile and facile cellular accumulation compensates for Mn2+ that has poor cellular accumulation due to continuous efflux, thus continuatively triggering the secretion of type I interferon for beyond 72 h. Remarkably, Mn/MoO3−x SANA significantly inhibits tumor growth and metastasis without supplementary STING agonists or external stimulation. This study offers a promising cascade cGAS/STING activation approach to enhance the efficacy and sustainability of catalytic metalloimmunotherapy.
Elucidating the Chemical Pre‐Lithiation Mechanism of Hard Carbon Anodes for Ultra‐high Stability Lithium‐Ion Batteries
Authors: Li Muxuan , Yuan Junsheng , Jin Mengjing , Ni Xia , Chang Peng , Sun Guowen , Pan Xiaojun 
Published: November 2024

AbstractThe hard carbon (HC) anode materials demonstrate high capacity and excellent rate performance in lithium‐ion batteries. However, HC anodes suffer from excessive loss of Li+ ions during the formation of the solid electrolyte interphase (SEI) film, leading to poor cycling stability, which hinders their large‐scale applications. Herein, a facile pre‐lithiation strategy is proposed to achieve multi‐functional precompensation of carbon nanofibers (CNFs) anodes. Both experimental and density functional theory (DFT) calculation results revealed that the strategy compensated for the loss of Li+ ions and reacted with four structures of CNFs during pre‐lithiation, including tiny graphite domains, CO‐containing functional groups, defects, and micropores. Furthermore, the lithium in pre‐lithiated carbon nanofibers (pCNFs) existed in various forms, consisting of LiC24 and LiC18, Li─O─C, quasi‐metallic lithium, and Li+ ions. Moreover, the uniformly distributed lithium on the surface of pCNFs induced the formation of denser and more robust LiF/Li2CO3‐rich SEI film, which promoted Li+ ions transport. As a result, pCNFs showed more stable cycling performance (369.8 mAh g−1, almost no decay for 1500 cycles). This work provides deeper insight into chemical pre‐lithiation and offers a simple and mild strategy for highly stable batteries.
Asymmetric Alkyl Chain Engineering for Efficient and Eco‐Friendly Organic Photovoltaic Cells
Authors: Wang Tao , Cui Yong , Ren Junzhen , Yu Yue , Wang Jianqiu , Yang Ni , Zhang Tao , Hou Jianhui 
Published: November 2024

AbstractRecent advancements in organic photovoltaic (OPV) cells have resulted in power conversion efficiencies (PCEs) surpassing 20%. However, the use of halogen solvents in the fabrication of OPV cells raises concerns due to their potential environmental and health impacts. In this work, a novel non‐fullerene small molecule acceptor BO‐AM‐4F, featuring an asymmetric alkyl chain design that includes a 2‐butyloctyl and a unique 6‐(hexylamino)‐6‐oxohexyl chain is synthesized. This design significantly improves molecular packing, crystallinity, and electrostatic potential distribution compared to the controlled acceptor DBO‐4F, which possesses symmetric 2‐butyloctyl chains. When combined with the polymer donor PBDB‐TF and processed using the non‐halogen solvent o‐xylene, the BO‐AM‐4F‐based OPV cell achieves an impressive PCE of 18.0%, surpassing the 16.6% PCE observed in the PBDB‐TF:DBO‐4F device. Furthermore, the PBDB‐TF:BO‐AM‐4F system demonstrates enhanced photostability and thermal stability compared to its DBO‐4F counterpart. These findings emphasize asymmetric alkyl chain engineering as an effective strategy for developing high‐performance, environmentally friendly OPV materials. This represents a significant step towards sustainable OPV technology.
Molecular Identification, Histopathology and Antibiotic Susceptibility Profiling of Aeromonas veronii Isolated from Oreochromis niloticus in Bangladesh
Authors: Bari Sayed Mashequl , Islam Mohammad Muttakinul , Amina Aktia , Khatun Marufa , Shahabuddin A. M. 
Published: November 2024

ABSTRACTBackgroundTilapia (Oreochromis niloticus) is the most widely cultured freshwater fish species in Bangladesh and worldwide. However, commercial tilapia culture systems face increasing challenges from bacterial infections.ObjectivesThe objective of this study was to identify the bacterial isolates from infected tilapia in an intensive cage culture farm located along the Shitalakshya River in Bangladesh.MethodsInfected fish samples were collected and underwent comprehensive clinical and post‐mortem investigations, followed by phenotypic, biochemical and molecular identification of the bacterial isolates, as well as histopathological and antibiotic susceptibility examinations.ResultsPhenotypic and biochemical characterization showed similarities of the ‐collected isolates with Aeromonas veronii. Moreover, molecular analysis of the bacterial conserved region 16S rRNA also confirmed these isolates as A. veronii. The analysed 16S rRNA sequence (GenBank accession no. PP832815) showed a close relationship (100% identity) with A. veronii from China (GenBank accession no. MT071624) in the NCBI BLAST search, and in the phylogenetic tree, they grouped in a single clade. This close genetic relationship is also supported by the low genetic distance between the isolates. Histopathological analysis revealed gross pathological changes like necrosis, hypertrophy and inflammation in muscle tissues. The isolates were found to be sensitive to multiple antibiotics but resistant to trimethoprim and sulphamethoxazole.ConclusionThis study investigated the presence of A. veronii infection in tilapia (O. niloticus) in an intensive cage culture farm in Bangladesh.
Three Stages of Nascent Protein Translocation Through the Ribosome Exit Tunnel
Authors: Kolář Michal H. , McGrath Hugo , Nepomuceno Felipe C. , Černeková Michaela 
Published: November 2024

ABSTRACTAll proteins in living organisms are produced in ribosomes that facilitate the translation of genetic information into a sequence of amino acid residues. During translation, the ribosome undergoes initiation, elongation, termination, and recycling. In fact, peptide bonds are formed only during the elongation phase, which comprises periodic association of transfer RNAs and multiple auxiliary proteins with the ribosome and the addition of an amino acid to the nascent polypeptide one at a time. The protein spends a considerable amount of time attached to the ribosome. Here, we conceptually divide this portion of the protein lifetime into three stages. We define each stage on the basis of the position of the N‐terminus of the nascent polypeptide within the ribosome exit tunnel and the context of the catalytic center. We argue that nascent polypeptides experience a variety of forces that determine how they translocate through the tunnel and interact with the tunnel walls. We review current knowledge about nascent polypeptide translocation and identify several white spots in our understanding of the birth of proteins.