bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct characteristics of MetALD (metabolic dysfunction‐associated steatotic liver disease with greater alcohol consumption) in the general population
Authors: Yoon Eileen L. , Park Huiyul , Hong Han Pyo , Lee Chul‐Min , Kim Mimi , Kang Bo‐Kyeong , Jun Dae Won 
Published: November 2024

AbstractAimThe term MetALD has been introduced to describe individuals who have metabolic dysfunction‐associated steatotic liver disease (MASLD) with greater alcohol consumption, according to the new nomenclature for steatotic liver disease (SLD). This study aims to evaluate the prevalence and clinical characteristics of MetALD in the general population.MethodsThis study is a retrospective, cross‐sectional analysis that utilizes the population‐based data from the Korea National Health and Nutrition Examination Survey (KNHANES) undertaken between 2019 and 2021. A total of 16 521 participants aged over 18 years were included in the analysis. The presence of hepatic steatosis was determined based on a hepatic steatosis index of 36 or higher.ResultsThe prevalence of MetALD was 2.8% (95% confidence interval, 2.5–3.2). Individuals with MetALD were predominantly men (85.4%) and tended to be younger compared to those with MASLD. They showed a higher prevalence of hypertension and had significantly higher levels of fasting glucose, triglycerides, high‐density lipoprotein cholesterol, and creatinine compared to individuals with MASLD. The average daily total energy intake was higher in the MetALD group. In addition, the MetALD group had a lower proportion of unemployment with higher income compared to the MASLD group.ConclusionPatients with MetALD showed distinct clinical characteristics from those with MASLD. The characteristics of MetALD were similar to those with alcohol‐related liver disease. Further analysis of MetALD across various regions and ethnic groups would be needed.
Daily requests and complaints in Spanish prisons: Looking beyond legal regulation
Authors: Larrauri Elena 
Published: November 2024

AbstractThis article deals with the right to make requests and complaints (RCs) inside Spanish prisons. It discusses the European Prison Rules and the principles set forward by the European Committee for the Prevention of Torture and Inhuman or Degrading Treatment or Punishment (CPT), examining how the Spanish system respects these. It then introduces the RCs system in Spain. Through research carried out in four prisons, interviews with the directors and with 21 inmates and taking as an example one prison, we were able to discover that the number of requests in one year is 55,000. This result reveals the formalised character of Spanish prisons and raises the question as to how to respond to RCs inside prison. The last part of the article draws on interviews with three Penitentiary Judges and discusses their role in reviewing RCs. In our analysis of 626 of the final decisions we found that 98.6% were denied. Finally, the article provides some explanations for this result and questions whether judges can be said to provide an effective remedy in such cases.
Effect of extraction and purification on the structure and activity of Flammulina velutipes polysaccharides: a review
Authors: Song Wanying , Li Mohan , Yue Xiqing , Zheng Yan 
Published: November 2024

SummaryFlammulina velutipes (F. velutipes) is one of the most widely consumed edible mushrooms worldwide. The growth of F. velutipes involves two primary stages: the mycelium and fruiting body. Unique polysaccharides are produced in each stage; mycelial polysaccharides (FVMPs) are produced during the mycelial fermentation stage, while fruiting body polysaccharides (FVFBPs) are produced during the fruiting stage. These polysaccharides, the major bioactive components of F. velutipes, have garnered significant attention due to their various functions and activities. Notably, they exert functional activities by mediating gut flora, including antioxidant, anti‐inflammatory, and immunomodulatory properties, reduce blood sugar and lipid levels, and enhance cognitive performance. This study examined the variations in FVMPs and FVFBPs resulting from different extraction and purification methods, with a specific focus on delineating their distinct structural characteristics. This study further explored the impact of the structural composition of FVMPs and FVFBPs on their health‐promoting properties, focusing on the relationship between their structures and their functional and biological effects. Finally, this study outlines future research avenues designed to contribute to the ongoing research in the field of bioactive FVMPs and FVFBPs.
NPF and sNPF can regulate the feeding behaviour and affect the growth and antioxidant levels of the rice brown planthopper, Nilaparvata lugens
Authors: Duan Rui‐Chuan , Zhang Yu‐Ning , Wang Yan‐Hui , Xie Bo‐Xuan , Du Zheng‐Ze , Chen Fa‐Jun 
Published: November 2024

AbstractNeuropeptide F (NPF) and short neuropeptide F (sNPF) are important neuropeptides and mainly affect feeding behaviour of insects. However, the regulation of insect feeding behaviour by NPF and sNPF appears to differ between species, and it is not clear how NPF and sNPF regulate the food intake of the brown planthopper (Nilaparvata lugens). Therefore, the functions of NPF and sNPF in regulating food intake and affecting the growth and antioxidant levels of N. lugens fed on host rice plants were investigated by knocking down NPF and sNPF respectively and simultaneously knocking down both of them by RNA interference. The results showed that NPF and sNPF were mainly expressed in the head of N. lugens, and N. lugens increased food intake after NPF and sNPF were knocked down, which was reflected in the prolonged duration of N4a and N4b waves in the electrical penetration graph (EPG) experiment after knocking down NPF and sNPF. In addition, knocking down NPF and sNPF led to the increase of body weight and mortality of N. lugens, and also led to the increase of antioxidant level of N. lugens. So it was concluded that NPF and sNPF could regulate food intake, maintain body weight stability and oxidative balance in N. lugens. Our study clarified the molecular mechanism of NPF and sNPF regulating feeding behaviour and affect the growth and antioxidant level of N. lugens.
The Organisational Characteristics That Enable Successful Employment Transition for People With Intellectual Disabilities
Authors: Joyce Andrew , Campbell Perri , Crosbie Jenny , Wilson Erin 
Published: November 2024

ABSTRACTBackgroundSocial enterprises have the potential to address some of the current barriers that people with an intellectual disability experience in transitioning to open employment opportunities. However, it is unknown in detail how social enterprises are able to facilitate this transition, which limits ability to scale‐up these organisational characteristics and strategies.MethodTwenty‐seven in‐depth interviews were conducted with staff, supported employees and partner organisations of a social enterprise to understand the organisational characteristics that enables successful transitions.ResultsThe organisational characteristics of the social enterprise that enabled transitions included offering a variety of roles and workplace environments for people with intellectual disabilities. Organisational characteristics also included having dedicated staff roles to support people with intellectual disabilities to develop skills to transition and for these support staff to network with open employers to facilitate the transition.ConclusionsThe results provide an adaptable model for other social enterprises in how to structure their organisation to facilitate transition to open employment opportunities.
Genome Dynamics of Adaptation and Introgression in Neotropical Palms
Authors: Pantoja Pauline O. , Vieira Lucas D. , de Lima Natácia E. , Sobral‐Souza Thadeu , Bacon Christine D. , Collevatti Rosane G. 
Published: November 2024

ABSTRACTAimThe combined influences of demographic dynamics and gene flow on local adaptation in plants is still poorly understood. Here, we used a genome scan approach on three closely related Neotropical palms, Acrocomia aculeata, A. intumescens and A. totai, to identify the evolutionary processes generating shared and lineage‐specific patterns of differentiation and selection across the genomic landscape.LocationAmazonia, Atlantic Forest, Cerrado and Caatinga ecoregions of Brazil.TaxaArecaceae.MethodsWe used target sequence capture and analysis of climatic correlation, detection of selective sweeps, balancing selection, and spatial and non‐spatial models to identify signatures of natural selection and admixture. We also determined temporal dynamics in spatial distribution and demographic changes.ResultsWe found a higher number of lineage‐specific than shared adaptive sites (SNPs) and no evidence of selective sweeps in shared genes, suggesting lineage specific natural selection across species. Further, evidence of balancing selection in several genes was also identified in the three species. Niche‐based and coalescent models suggest that shifts in spatial range during the Quaternary caused overlapping distributions between species, leading to hybridisation between parapatric localities.Main ConclusionsInterspecific hybridisation may have spread both neutral and adaptive SNPs, which may explain the shared adaptive genes between species. Taken together, we show how genomic adaptation can occur despite introgression, through evolutionary processes that likely drive similar patterns of adaptation in other organisms.
Island Biogeography Theory and the Island Rule in Orchid Bees in Panama
Authors: Vega‐Rovira Yosiat A. , Bennett‐Vaz Richard , Araúz Gabriel , Añino Yostin , Gálvez Dumas 
Published: November 2024

ABSTRACTAimThe study of the theory of island biogeographic (TIB) has focused mainly on plants and vertebrates, with support for the predictions that species richness decreases with distance from the mainland and increases with island size. However, less work has been done on invertebrates. Similarly, the study of the island rule has been studied mainly in vertebrates. A group of invertebrates that can facilitate the study of TIB and the island rule are orchid bees (Apidae: Euglossini), because they are easily collected and show powerful flight performances that allows them to travel long distances. We wondered if these bees would follow the predictions of island biogeography, given that their populations may not be isolated across islands. To test if there is an homogenitazion of orchid bee communities across islands, we evaluated orchid bees abundance and species composition across islands. Besides, we tested the island rule by examining body size variations in individuals collected across islands.LocationCoiba National Park (Panama).Time PeriodMay and June 2023.TaxaOrchid bees (Hymenoptera: Apidae: Euglossini).MethodsBy using traps with chemical attractants, we sampled male bees from five islands and the mainland in Coiba National Park in the Pacific side of Panama. We tested the TIB by evaluating whether richness decreased with distance from the mainland or whether increased with island area. To investigate the island rule, and whether there is variation in body size across islands, we used Euglossa imperialis and Euglossa mixta as models, the two most abundant species in the study area.ResultsFor the overall orchid bee community, we found that our results fit one of the predictions of IBT, increases in orchid bee abundance with island area; however, species richness did not decrease with isolation and did not increase with island area as predicted by TIB. An interesting result was that as distance from the mainland increased few species became more dominant. Regarding the island rule, we found in the two Euglossa species a marked pattern of reduction in body size as distance from the mainland increased, which seems to outweigh the effect of island size, since the largest island and one of the farthest showed some of the smallest body sizes.Main ConclusionsWhether euglossine bees travel long distances across islands in marine environments remain unclear. As distance from the mainland increases, few species become dominant, which may be caused by a decrease of resources that favours generalist species. This increase in abundance may explain the decrease in body size with isolation, as perhaps competition for resources increases. Our study provides novel insights to better appraise the dynamics of orchid bees' communities in insular habitats.
Association of Questionnaire‐Assessed Fall Risk With Uncontrolled Blood Pressure and Therapeutic Inertia Among Older Adults
Authors: Hiura Grant T. , Markossian Talar W. , Probst Beatrice D. , Habicht Katherine , Kramer Holly J. 
Published: November 2024

ABSTRACTTherapeutic inertia (TI), or failure to escalate or initiate BP lowering medications when BP is uncontrolled, increases with advancing age and may in part be due to perceived fall risk. This study examined the association of a fall risk assessment, based on patient response to three questions administered by trained staff, with uncontrolled BP (≥140/90 mmHg) during a clinic visit and with TI during clinic visits with uncontrolled BP among 13 893 patients age ≥ 65 years corresponding to 41 122 primary care visits. Separate generalized linear mixed effects models were used to examine the association of fall risk (low, moderate, and high) with uncontrolled BP and with TI at a clinic visit after adjustment for demographics, comorbidities, and total number of visits. Baseline mean age was 73.0 years (standard deviation [SD] 5.6), 43.3% were men and questionnaire‐assessed fall risk severity was low in 73.6%, moderate in 14.3%, and high in 12.2%. Compared to low fall risk, the adjusted odds of uncontrolled BP during a clinic visit were 0.97 (95% CI: 0.89, 1.06) and 0.90 (95% CI: 0.82, 0.98) with moderate and high fall risk, respectively. In contrast, adjusted odds of TI during a clinic visit with BP ≥ 140/90 mmHg was 1.16 (95% CI: 1.01, 1.34) and 1.30 (95% CI: 1.11, 1.52) with moderate and high fall risk, respectively, compared to low fall risk. These findings suggest that perceived fall risk severity may be one of several factors that influence hypertension management in older adults.
Europe's Super‐Rich: Towards Oligarchic Constitutional Order
Authors: Regilme Salvador Santino 
Published: November 2024

AbstractThis article addresses an important but understudied puzzle in European Union Studies: the super‐rich's influence on domestic and transnational discourses, policies and institutions for wealth defence, security and legitimacy. It examines the super‐rich's impact on democratic governance and human rights claims of marginalized groups, and how states, civil society and non‐oligarchic entities contest oligarchic rule. The article proposes a research agenda to determine if Europe can be seen as an oligarchic constitutional order, characterized by governance practices and authority structures deeply intertwined with the super‐rich's interests in transnational and domestic politics. The framework in this research agenda underscores how institutional arrangements, legitimating principles, regulatory practices and procedural systems increasingly favour the super‐rich, reflecting a dominant mode of transnational governance rooted in extreme socio‐economic stratification. The research agenda aims to elucidate the tension between wealth and democratic governance, particularly how policies and normative discourses often align with the super‐rich's interests despite resistance from marginalized groups.
Callous‐unemotional traits, cognitive functioning, and externalizing problems in a propensity‐matched sample from the ABCD study
Authors: Murtha Kristin , Perlstein Samantha , Paz Yael , Seidlitz Jakob , Raine Adrian , Hawes Samuel , Byrd Amy , Waller Rebecca 
Published: November 2024

BackgroundMany studies show that both callous‐unemotional (CU) traits (e.g., low empathy, lack of guilt) and cognitive difficulties increase risk for externalizing psychopathology across development. However, other work suggests that some aggression (e.g., relational, proactive) may rely on intact cognitive function, which could vary based on the presence of CU traits. Moreover, no prior research has adequately accounted for common risk factors shared by CU traits, cognitive difficulties, and externalizing problems, which confounds conclusions that can be drawn about their purported relationships. The current study addressed these knowledge gaps by leveraging rigorous propensity matching methods to isolate associations between CU traits and different dimensions of cognitive function and externalizing problems.MethodsAssociations between CU traits, cognitive functioning, and externalizing outcomes were tested within dimensional (n = 11,868) and propensity‐matched group‐based (n = 1,224) models using data from the Adolescent Brain Cognitive Development Study®, with rigorous statistical control for shared sociodemographic risk factors. Cross‐sectional outcomes were parent‐reported symptoms of conduct disorder (CD), oppositional defiant disorder (ODD), and attention deficit hyperactivity disorder (ADHD). Longitudinal outcomes were child‐reported overt and relational aggression.ResultsCU traits were uniquely related to more parent‐reported CD, ODD, ADHD symptoms, as well as more child‐reported aggressive behaviors. Effects of cognitive difficulties were domain specific and were not consistent across dimensional and propensity matched models. There was minimal evidence for divergent associations between CU traits and externalizing outcomes as a function of cognition (i.e., no moderation).ConclusionsRigorous control for sociodemographic factors within propensity‐matched models establish CU traits as a robust and unique risk factor for externalizing psychopathology, over and above difficulties with cognitive functioning.
Childhood predictors of avoidant personality disorder traits in adolescence: a seven‐wave birth cohort study
Authors: Wichstrøm Lars , Wilberg Theresa , Hartveit Kvarstein Elfrida , Steinsbekk Silje 
Published: November 2024

BackgroundAlthough it is widely assumed that avoidant personality disorder (AvPD) originates in childhood, there is little prospective research to substantiate this claim. We therefore aimed to determine whether presumed childhood risk factors predict AvPD traits at 16 years.MethodsA population‐based sample (n = 1,077; 50.9% female) from the 2003 and 2004 birth cohorts in Trondheim, Norway was examined biennially from 4 to 16 years. The number of AvPD traits at the age of 16 was assessed with the structured clinical interview for DSM‐5 personality disorders and regressed on the intercept and growth in child risk and protective factors until the age of 14.ResultsThe prevalence of AvPD at the age of 16 was 3.2% (95% CI: 2.2–4.1). Higher levels and an increased number of social anxiety symptoms over time, as well as increased negative affectivity/neuroticism, predicted a higher number of AvPD traits. When the levels and changes in these factors were adjusted for, less and decreasing extraversion forecasted more AvPD traits, as did declining self‐worth, higher levels of parental AvPD traits, and increased onlooking behavior.ConclusionsNeuroticism, low extraversion, social anxiety symptoms, passive onlooking behavior, and low self‐worth predicted a higher number of AvPD traits in adolescence, as did more AvPD traits in parents. Efforts to enhance self‐worth, reduce social anxiety, and promote peer interaction among onlooking children may reduce the development of AvPD traits in adolescence.
Optimizing the Precipitation of Bioactive Compounds From Extracted Curcuma longa Linn. Using Gas Anti‐Solvent Process
Authors: Charoenchaitrakool Manop , Lengmangmee Chatchai , Youngkum Patcharaporn 
Published: November 2024

ABSTRACTTurmeric is a medicinal herb that can be used in a wide range of applications, such as food ingredients, cosmetics, and traditional medicine. The active ingredients found in turmeric are curcumin (CUR), desmethoxycurcumin (DMC), and bisdesmethoxycurcumin (BMDC). The aim of this research was to precipitate the active ingredients from a turmeric extract using the gas anti‐solvent process with carbon dioxide as the anti‐solvent. The effects of solvent type (ethanol, methanol, and acetonitrile), precipitation temperature (25°C–45°C), and CO2 flow rate (4–12 mL/min) on the amount of precipitates were investigated using the Box–Behnken design of experiments. The precipitates were analyzed for curcuminoids and CUR content using HPLC and were tested for antioxidant activity. It was found that solvent type and temperature were significant variables at a 5% significance level on the amount of precipitates. Using a mixture of ethanol and methanol (77.5% v/v ethanol) with a polarity index of 4.48 as the solvent, a precipitation temperature of 25.40°C, and a CO2 flow rate of 7.56 mL/min was found to be the optimal conditions for achieving the highest amount of precipitates. At the optimal conditions, the amounts of curcuminoids and CUR precipitates were found to be 27.33 ± 0.23 and 13.30 ± 0.12 mg/5 mL of extracted solution, respectively. In the antioxidant studies, the Trolox equivalents found in the products at the optimal conditions using DPPH and ABTS assays were 38.19 ± 0.17 and 65.96 ± 2.36 mg/5 mL of extracted solution, respectively. The total phenolic content was found to be 30.84 ± 1.80 mg/5 mL of extracted solution.
Malignant peripheral nerve sheath tumor of the cervix in an adolescent with neurofibromatosis type 1: A case report and review of literature
Authors: Furuzono Nozomi , Togami Shinichi , Kitazono Ikumi , Nishikawa Takuro , Tanimoto Akihide , Kobayashi Hiroaki 
Published: November 2024

AbstractMalignant peripheral nerve sheath tumors (MPNSTs) of the cervix are rare, particularly in patients with neurofibromatosis type 1 (NF1). This report describes a cervical MPNST in an 18‐year‐old patient with no history of sexual activity, abnormal vaginal discharge, and prolonged menstruation. She had more than six café‐au‐lait spots on her body since birth and was diagnosed with NF1 at 2 years of age. Positron emission tomography‐computed tomography revealed a large pelvic mass and lung and bone metastases. Biopsy confirmed MPNST. Immunohistochemical staining showed diffuse positivity for CD10, approximately 30% positivity for cyclin D1, partial positivity for α‐SMA, desmin, and MyoD1, and negativity for myogenin, S‐100, and SOX‐10. A cancer gene panel identified several genetic abnormalities, but none were actionable mutations. Despite systemic chemotherapy, the tumor progressed rapidly, and the patient died 8 weeks post‐admission. Early diagnosis of MPNST is crucial. In patients with NF1, even mild symptoms can indicate MPNST.
The risk screening effect of digital insurance distribution
Authors: Murphy Finbarr , Xu Wei , Xu Xian 
Published: November 2024

AbstractExtant research holds that digital sales channels advance competition and service or goods availability but rarely details the attendant information asymmetry. Leveraging a large unique dataset, this study examines a specific case in which consumers have a choice between offline and digital channels for insurance purchases. We find that digital channels screen in consumers with lower unobserved risk. For term life, endowment and disease insurance products, the average risks of the policies purchased through digital channels were significantly lower than those purchased offline after controlling for all observed risk characteristics. This risk screening effect mainly comes from the inclusion of new low‐risk enrollees. As a consequence, digital channels exhibit lower information asymmetry and greater profitability compared to offline channels.