bluuebunny/crossref_metadata_2025_split huggingface dataset:
METASPACE: A community-populated knowledge base of spatial metabolomes in health and disease
Authors: Alexandrov Theodore , Ovchinnikova Katja , Palmer Andrew , Kovalev Vitaly , Tarasov Artem , Stuart Lachlan , Nigmetzianov Renat , Fay Dominik ,   Key METASPACE contributors, Gaudin Mathieu , Lopez Cristina Gonzalez , Vetter Marina , Swales John , Bokhart Mark , Kompauer Mario , McKenzie James , Rappez Luca , Velickovic Dusan , Lavigne Regis , Zhang Guanshi , Thinagaran Dinaiz , Ruhland Elisa , Sans Marta , Triana Sergio , Sammour Denis Abu , Aboulmagd Sarah , Bagger Charlotte , Strittmatter Nicole , Rigopoulos Angelos , Gemperline Erin , Joensen Asta Maria , Geier Benedikt , Quiason Christine , Weaver Eric , Prasad Mridula , Balluff Benjamin , Nagornov Konstantin , Li Lingjun , Linscheid Michael , Hopf Carsten , Heintz Dimitri , Liebeke Manuel , Spengler Bernhard , Boughton Berin , Janfelt Christian , Sharma Kumar , Pineau Charles , Anderton Christopher , Ellis Shane , Becker Michael , Pánczél József , Violante Georges Da , Muddiman David , Goodwin Richard , Eberlin Livia , Takats Zoltan , Shahidi-Latham Sheerin 
Published: February 2019

AbstractMetabolites, lipids, and other small molecules are key constituents of tissues supporting cellular programs in health and disease. Here, we present METASPACE, a community-populated knowledge base of spatial metabolomes from imaging mass spectrometry data. METASPACE is enabled by a high-performance engine for metabolite annotation in a confidence-controlled way that makes results comparable between experiments and laboratories. By sharing their results publicly, engine users continuously populate a knowledge base of annotated spatial metabolomes in tissues currently including over 3000 datasets from human cancer cohorts, whole-body sections of animal models, and various organs. The spatial metabolomes can be visualized, explored and shared using a web app as well as accessed programmatically for large-scale analysis. By using novel computational methods inspired by natural language processing, we illustrate that METASPACE provides molecular coverage beyond the capacity of any individual laboratory and opens avenues towards comprehensive metabolite atlases on the levels of tissues and organs.
Both the inflammatory response and clinical outcome differ markedly between adults with pneumococcal and meningococcal meningitis in a high HIV-1 prevalent setting in sub-Saharan Africa
Authors: Wall Emma C , Guerra-Assunção José Afonso , Denis Brigitte , Scarborough Matthew , Ajdukiewicz Katherine , Cartwright Katharine , Mukaka Mavuto , Mlozowa Veronica S , Venturini Cristina , Allain Theresa J , Lalloo David G , Brown Jeremy S , Gordon Stephen B , Heyderman Robert S 
Published: February 2019

AbstractOutcomes from pneumococcal meningitis (PM) are worse than meningococcal meningitis (MM), particularly in settings with high HIV-1 prevalence, but the reasons are unknown. We compared inflammatory responses between PM and MM in Malawian adults.As compared to MM (n=27, 67% HIV-infected, mortality 11%), patients with PM (n=440, 84% HIV-infected, mortality 54%) were older, had strikingly lower CSF WCC, higher pro-inflammatory cytokine concentrations and higher mortality. PM is characterized by significantly lower CSF WCC, but greater inflammation and higher mortality compared to MM. Mechanistic understanding of blunting of the CSF leukocyte response in PM in-vivo is required.
Relating brain connectivity with persistent symptoms in pediatric concussion
Authors: Iyer Kartik K. , Barlow Karen M. , Brooks Brian , Ofoghi Zahra , Zalesky Andrew , Cocchi Luca 
Published: February 2019

ABSTRACTPersistent post-concussion symptoms (PCS) in children following a mild traumatic brain injury (mTBI) is a growing public health concern. There is a pressing need to understand the neural underpinning of PCS. Here, we examined whole-brain functional connectivity from resting-state fMRI with behavioral assessments in a cohort of 110 children with mTBI. Children with mTBI and controls had similar levels of connectivity. PCS symptoms and behaviors including poor cognition and sleep were associated with connectivity within functional brain networks. The identification of a single “positive-negative” dimension linking connectivity with behaviors enables better prognosis and stratification towards personalized therapeutic interventions.
Polled Digital Cell Sorter (p-DCS): Automatic identification of hematological cell types from single cell RNA-sequencing clusters
Authors: Domanskyi Sergii , Szedlak Anthony , Hawkins Nathaniel T , Wang Jiayin , Paternostro Giovanni , Piermarocchi Carlo 
Published: February 2019

AbstractBackgroundSingle cell RNA sequencing (scRNA-seq) brings unprecedented opportunities for mapping the heterogeneity of complex cellular environments such as bone marrow, and provides insight into many cellular processes. Single cell RNA-seq, however, has a far larger fraction of missing data reported as zeros (dropouts) than traditional bulk RNA-seq. This makes difficult not only the clustering of cells, but also the assignment of the resulting clusters into predefined cell types based on known molecular signatures, such as the expression of characteristic cell surface markers.ResultsWe present a computational tool for processing single cell RNA-seq data that uses a voting algorithm to identify cells based on approval votes received by known molecular markers. Using a stochastic procedure that accounts for biases due to dropout errors and imbalances in the number of known molecular signatures for different cell types, the method computes the statistical significance of the final approval score and automatically assigns a cell type to clusters without an expert curator. We demonstrate the utility of the tool in the analysis of eight samples of bone marrow from the Human Cell Atlas. The tool provides a systematic identification of cell types in bone marrow based on a recently-published manually-curated cell marker database [1], and incorporates a suite of visualization tools that can be overlaid on a t-SNE representation. The software is freely available as a python package at https://github.com/sdomanskyi/DigitalCellSorterConclusionsThis methodology assures that extensive marker to cell type matching information is taken into account in a systematic way when assigning cell clusters to cell types. Moreover, the method allows for a high throughput processing of multiple scRNA-seq datasets, since it does not involve an expert curator, and it can be applied recursively to obtain cell sub-types. The software is designed to allow the user to substitute the marker to cell type matching information and apply the methodology to different cellular environments.
An evidence-based faculty recruitment workshop influences departmental hiring practice perceptions among university faculty
Authors: Sekaquaptewa Denise , Takahashi Koji , Malley Janet , Herzog Keith , Bliss Sara 
Published: February 2019

PurposeMany university programs seek to promote faculty diversity by reducing biases in hiring processes. The purpose of this paper is to conduct two studies to test the individual- and department-level impact of a faculty recruitment workshop (FRW) on faculty attitudes toward evidence-based, equitable hiring practices.Design/methodology/approachStudy 1 included 1,188 faculty who had or had not attended an FRW. Respondents were surveyed about their attitudes and their intentions to use specific equitable search practices. The authors assessed the proportion of faculty in each department to test for the impact of department-level workshop attendance on individual faculty attitudes. Study 2 employed a similar design (with 468 faculty) and tested whether effects of workshop attendance are explained by changes in beliefs about social science research.FindingsFaculty had more favorable attitudes toward equitable search strategies if they had attended a workshop or if they were in a department where more of their colleagues had. Workshop attendance also increased intentions to act on two of three recommendations measured, and led to greater belief in evidence-based descriptions of gender biases. Some evidence suggested that these beliefs mediated the influence of the FRW on attitudes.Research limitations/implicationsBecause faculty were not randomly assigned to attend the workshop, no strong claims about causality are made.Practical implicationsThe present studies demonstrate that an evidence-based recruitment workshop can lead faculty to adopt more favorable attitudes toward strategies that promote gender diversity in hiring.Originality/valueThese studies provide evidence of the role of belief in social science research evidence in explaining the effectiveness of a program designed to increase faculty diversity.
Department of Tourism and Culture – Abu Dhabi: transforming the desert into a city
Authors: Al Dhaheri Mariam Hamad , Ahmad Syed Zamberi 
Published: February 2019

Supplementary materials
Teaching notes are available upon request.

Learning outcomes
The purpose of this paper is to enable tourism management and strategic management students to evaluate and analyze tourism activities in the United Arab Emirates by TCA. Students will gain a comprehensive understanding of developing tourism in rural areas in the United Arab Emirates and to build up proper strategies. They will be able to perform the organization’s competitive standing using Porter’s Five competitive forces and analyze its business strategies as well. They will be able to analyze the current status of the organization using SWOT analysis and to design alternative strategies for the company using TOWS analysis.

Case overview/synopsis
The Department of Tourism and Culture – Abu Dhabi, also known as the TCA, is a governmental tourism authority in the Emirate of Abu Dhabi established 14 years ago as part of an economy-diversifying strategy for the non-oil era. The TCA is responsible of creating tourism activities to generate new tourists in Abu Dhabi, which will increase the revenue of the authority and as well increase the gross domestic product of the United Arab Emirates (UAE) economy. Tourism activities have been focused on Abu Dhabi City as is it considered the capital city of the UAE. However, other cities are also part of this strategy, e.g. Al Ain City, which is located in the eastern region of the Emirate of Abu Dhabi, and Al Dhafra City, which is located in the western region of the Emirate of Abu Dhabi, both of which lack the required infrastructure, population, and tourism activity, due in part at least to the fact that the TCA’s strategy plans have been focused on Abu Dhabi City. Sultan Al Mutawa Al Dhaheri (Al Dhaheri), the TCA’s Executive Director of Tourism, has been responsible for developing tourism in Al Ain City and Al Dhafra, but due to the current situation of the two cities regarding the low revenue growth (and the consequent lack of investors willing to invest) and no critical mass (i.e. a sufficient number of hotel rooms available), Al Dhaheri is facing a dilemma regarding achieving TCA strategy in Al Ain City and Al Dhafra City.

Complexity academic level
This case study will be useful for undergraduate and postgraduate level students majoring in Tourism and Hospitality Management, Business Administration and Strategic Management.

Subject code
CSS 12: Tourism and Hospitality.
Calculative and collaborative HRM practices, turnover and performance
Authors: Cristiani Alvaro , Peiró José M. 
Published: February 2019

PurposeThe purpose of this paper is to study the human resource management (HRM)–performance linkage by exploring alternative relationships between different HRM practices, categorised as either calculative or collaborative, and employee turnover and organisational and financial outcomes, in Uruguayan multinational companies (MNCs) and domestic companies, to better understand the implications of the Latin American context in this relationship.Design/methodology/approachThe study is performed at the firm level, using data from a representative sample of 274 firms, including both multinationals and locally owned firms in Uruguay, collected through the Cranet 2009 survey. The authors tested the hypotheses of the proposed model using structural equation modelling (SEM) and hierarchical multiple regression analysis.FindingsEmpirical results show that collaborative HRM practices are significantly related to lower employee turnover rates, whereas calculative HRM practices are significantly associated with higher organisational and financial outcomes. These findings show the importance of the Latin American context in the relationships between HRM practices and firms’ outcomes.Research limitations/implicationsThe use of survey data with single respondents might produce reliability problems. Additionally, the data used are cross-sectional, making it difficult to determine causality.Practical implicationsManagers in MNCs and local firms in the context of developing economies and Latin American cultures must be aware that different types of HRM practices will influence different outputs and impacts on overall outcomes.Originality/valueThe paper examines the extent to which HRM practices have a significant relationship with firm performance. In addition, it identifies the differential effects of calculative and collaborative HRM practices on performance, using data from a Latin American contextual setting rarely examined, in order to determine similarities and differences from results obtained in US and European contexts.
Tell me your age and I tell you what you trust: the moderating effect of generations
Authors: Herrando Carolina , Jimenez-Martinez Julio , Martin-De Hoyos M.J. 
Published: February 2019

Purpose
The proliferation of social commerce websites has allowed consumers to share and exchange information, experiences, advice and opinions. Recently, information provided by users has been considered more trustworthy than the information shared by companies. However, the way in which users interact with technology can vary with age, and generational cohorts show different shopping behaviors, interests and attitudes. Hence, the way users process information (user-generated vs company-generated) can affect trust differently. Drawing on the trust transfer theory and the generational cohort theory, the purpose of this paper is to analyze the effects on user- and company-generated information in boosting trust of three different cohorts (Generation X, Y and Z).

Design/methodology/approach
The data were collected through an online survey. The sample comprised 715 users of social commerce websites, aged between 16 and 55 years old. The study was analyzed using partial least squares with the statistical software Smart PLS 3.

Findings
The empirical results show that generational cohorts show different patterns. Generation X transfers trust to social commerce websites mainly from trust in information generated by companies, while Generation Z transfers trust mainly from information generated by users. Finally, Generation Y, in contrast to previous findings about millennials, develops trust based on company-generated information to an even greater extent than does Generation X.

Originality/value
The originality of this study lies in its analysis of generational differences when it comes to trusting one type of information over another. This study contributes to the idea that users cannot be considered as a whole but must be segmented into generational cohorts.
Intrapreneurial behavior in higher education institutes of Pakistan
Authors: Farrukh Muhammad , Lee Jason Wai Chow , Shahzad Imran Ahmed 
Published: February 2019

PurposeThe dynamic business environment of all industries is forcing organizations to restructure their organizational philosophy and strategies to gain and maintain competitive advantage. To grapple with this rapidly changing environment, organizations are required to be more intrapreneurial in their operations. However, very few studies have been conducted on knowing the antecedent of intrapreneurship in organizations; thus the purpose of this paper is to fill this gap. This study strived to investigate the association among styles of leadership and intrapreneurial behavior (IB) of employees in the presence of psychological empowerment (PE) as mediator in higher educational institutes in Pakistan.Design/methodology/approachA deductive approach of logic was taken to formulate and test the hypotheses. A structured questionnaire was developed and sent to 350 Academic staff of Universities in Pakistan, out of which 280 responses were collected. A structured equation modeling technique was utilized to analyze the hypotheses.FindingsFindings revealed a positive impact of transformational leadership (TL) and authentic leadership on IB, while a negative association between transactional leadership and IB was found. Contrary to these results, no significant association was observed between IB and passive- avoidant leadership. In addition, mediation analysis was run using the bootstrapping function of SmartPLS. Results showed that the association among TL, authentic leadership and IB were mediated by PE; however, the association of transactional leadership, passive-avoidant leadership and IB was not mediated by empowerment.Originality/valueThis study contributed to the knowledge domain of leadership as well as intrapreneurship. The study may help practitioners and academicians understand organizational factors such as leadership behavior, which might foster IB.
Muslim academics’ knowledge sharing in Malaysian higher learning institutions
Authors: Ashraf Fauzi Muhammad , Tan Nya-Ling Christine , Thurasamy Ramayah , Oluwaseyi Ojo Adedapo , Shogar Ibrahim 
Published: February 2019

Purpose
The purpose of this paper is to investigate Muslim academics’ knowledge sharing (KS) behavior and its relating predictors in the context of Malaysia. Academics being the center entity of education in higher learning institutions (HLI) has the noble obligation in spreading and sharing knowledge. Moreover, in Islamic teaching, academics having knowledge must let others know that knowledge can be beneficial in everyday life.

Design/methodology/approach
The underpinning theories used in this study are theory of planned behavior (TPB) and social capital theory (SCT) for assessing the probable factors that can determine academics’ KS behavior. This study evaluates 398 Muslim academics in Malaysia for KS behavior in 20 public and 5 private HLIs. Structural equation modeling–partial least square was used as the tool for data analysis.

Findings
It was found that all the variables tested in this study were significant, except for commitment. Social network, trust, management support, facilitating conditions and social media are significant predictors in Muslim academics’ KS behavior.

Research limitations/implications
The findings would enable HLIs to inculcate and enhance KS among academics in terms of theoretical and managerial perspectives.

Originality/value
This study integrates TPB, SCT and other individual, organizational and technological factors for assessing Muslim academics in Malaysia. Thus, generalization on Muslim academics can be attained in South Asian countries.
Directors’ trades in UK rights issues: do firms sell overvalued new equity?
Authors: Ali Heba Ahmed Abbas 
Published: February 2019

PurposeThis paper aims to examine the behavioral timing hypothesis in the context of UK rights issues by seeking to establish and investigate inter-relationships between directors’ trading around rights issues as a proxy for stock mis-valuation and post-issue stock price performance.Design/methodology/approachThe cumulative average abnormal returns, the buy and hold abnormal returns, the standardized residual cross-sectionalt-test and the generalized sign test techniques.FindingsThe directors do possess short-term timing ability as they can identify profitable trading situations by buying more often before stock outperformance and by selling more often before stock underperformance. In addition, directors trading prior to the rights offering is found to exert an influence on the long-run abnormal returns of the rights-issuing firm, which supports the story that mis-valuation and behavioral timing are empirical.Research limitations/implicationsOther types of seasoned equity offerings rather than rights issues should be included.Practical implicationsThe research provides a direct testing for the strong form of market efficiency hypothesis, which enables policymakers to take into account market reaction to directors’ trades and how it is affected by corporate events (e.g. rights issues) when addressing insider trading regulations.Originality/valueThis study extends available literature in the context of both developed and emerging equity markets to testing the behavioral timing hypothesis by testing the inter-relationships between directors’ trading around rights issues and post-issue short- and long-run performance. To the best of the author’s knowledge, this is the first study that examines these inter-relationships in the UK context.
Constraint‐induced movement therapy for upper limb recovery in adult neurorehabilitation: An international survey of current knowledge and experience
Authors: Christie Lauren J. , McCluskey Annie , Lovarini Meryl 
Published: February 2019

IntroductionConstraint‐induced movement therapy (CIMT) is an effective intervention for upper limb recovery following stroke and traumatic brain injury. Despite strong evidence, the use of CIMT in practice is limited. The aim of this study was to investigate clinician knowledge and experience of delivering CIMT protocols internationally in neurorehabilitation.MethodsA cross‐sectional survey was conducted online. The survey was distributed through occupational therapy and physiotherapy associations, neurological interest groups and list serves in 11 countries. Passive snowball sampling was used to recruit participants. Descriptive and inferential statistics were used for analysis.ResultsComplete surveys were returned by 169 respondents (64.5% occupational therapists; 34.3% physiotherapists; 1.2% other). Most respondents were from the United Kingdom (36.1%), Australia (28.4%) and Denmark (7.7%). Most participants delivered CIMT to individuals (79.3%) rather than in groups. A modified version of CIMT was used most often (74.6%), with one hour sessions per day (30.2%), provided to stroke survivors (96.4%) and people with traumatic brain injury (37.3%). Most respondents (88.8%) used intensive graded practice as a component of a CIMT program, but only 43.2% reported using a mitt restraint for most waking hours, and only 38.5% used a transfer package.ConclusionThese findings suggest that CIMT is being used globally but not always with fidelity to the original trials. A range of strategies are needed for improving clinicians’ knowledge and skills to increase the frequency of program delivery and enhance program delivery with fidelity.