bluuebunny/crossref_metadata_2025_split huggingface dataset:
Past, Present, and Persecution
Authors: Harper Steven C. 
Published: August 2019

Abstract
Every memory has a culture, and Joseph Smith’s best-known account of his first vision (the 1838/39 account) consolidated in a hostile environment. Smith and his people were driven from Missouri by the governor’s executive order, he was jailed during the winter of 1838–39, and then he escaped to reunite with his exiled followers in Illinois. There he and associates renewed work on a manuscript history that begins with a defensive and defiant account of his first vision. The saints eventually canonized this version of Smith’s memory. It shapes their identity as a people persecuted for transcending creedal Christianity and accessing God directly. That outcome was not inevitable.
First Communication
Authors: Harper Steven C. 
Published: August 2019

Abstract
The long shadow cast by the minister’s rejection explains why Smith’s memory formed and re-formed as it did in the context of later experiences. In 1835 Joseph Smith consolidated, and his scribe recorded, a spontaneous memory of his first vision. It differs markedly from his other accounts primarily because it was cued spontaneously by a conversation, not by a premeditated effort to record autobiography. It shows that, given the right cues and context, he could make a memory that did not need to respond to the Methodist minister, whether to please him (as in 1832) or to rebuke him (as in 1838/39).
Extract from His History
Authors: Harper Steven C. 
Published: August 2019

Abstract
Joseph Smith grew up in a visionary family that lived in a visionary culture, but nothing in the historical record reveals that he told his family about his first vision in the 1820s. Many modern saints easily recall that, when Smith returned home after his vision, he told his mother. But all the historical record—an 1842 redaction to the 1838/39 account—says is that he told his mother what he learned, not how. There is no evidence that he told anyone but the Methodist minister for a decade. There is no known evidence of him relating his experience to family members or others. In 1832, Smith remembered that he could find no one that believed him.
Straightforward Recital
Authors: Harper Steven C. 
Published: August 2019

Abstract
Artistically written recursions of Joseph Smith’s first vision also began to appear in the 1880s, particularly through George Cannon and Andrew Jenson. These stories, while not intended to be historical representations, reflected and contributed to the recursion of collective memory and its transmission to the next generation. Distortion, while inevitable with retellings, occurs as the remembering entity favors coherence over accuracy. Forging collective memory from art, music, and print created by a shared memory and a multitude of individual ones, each inevitably distorted compared to Joseph Smith’s own memories of his first vision. But for all that, the collective memory the saints forged became incredibly strong, resilient, and extremely well known to them.
The Joseph (F.) Smith Story
Authors: Harper Steven C. 
Published: August 2019

Abstract
Following the death of Lorenzo Snow in 1901, Joseph F. Smith was next in the line of prophetic successors. Joseph F. became the prophet and president of The Church of Jesus Christ of Latter-day Saints in autumn. He ramped up efforts to commemorate Joseph Smith’s birthday and especially to rehearse his first vision. In the turn-of-the-century crisis that threatened to undermine Mormonism, Joseph F. Smith’s selection, relation, and repetition of the story of his uncle’s first vision helped the saints navigate their way to a new narrative, one in which plural marriage could be relinquished without eroding the saints’ faith in revelations received by their prophets past or present.
Under Attack
Authors: Harper Steven C. 
Published: August 2019

Abstract
Drawing on newly discovered accounts (1832, 1835) and lots of contextual research, James Allen and Milton Backman added an alternative memory to the buffer on which the saints could draw for memory resources. Believing historians formed a faithful, complex understanding of Smith’s vision that accounted for the incongruity the critics saw in the historical record. The believing historians selected and related new items to old ones. They showed how new elements could be integrated recursively with the long-established story. The laity hardly noticed, however. Compared to the expanding number of Mormons whose conversions were often tied to the canonized account of Smith’s first vision, Mormon historians were a tiny minority. Publishing their findings did almost nothing to alter the Mormon collective memory or make it more resilient to critics. The disruptive potential of the newly discovered records and ways of interpreting them remained latent, waiting for an information age to unleash it.
Afterword
Authors: Harper Steven C. 
Published: August 2019

Abstract
By 2015, Latter-day Saints were beginning to consolidate a more resilient cultural memory of Smith’s vision based on unabashed selection, relation, and repetition of Smith’s accounts in church curriculum. Curriculum a generation earlier had avoided any potential first vision controversies. Richard Bushman’s biography of Joseph Smith had been banned, not his interpretation of Smith’s accounts was the curriculum, having been officially selected, related, and repeated via media that was much more likely than a lecture or a textbook to modulate memory formation in young Latter-day Saints. The consolidation of their shared memory will take time. So will the recursion process by which elements are added or subtracted and new memories form. Within a generation, relatively few saints will remember any of the earlier versions of their shared knowledge. This book will preserve those memories.
Innovative Global Health Care Experiences for Nursing Students: Microsemesters and Internships
Authors: Graber Jennifer S. , Saylor Jennifer , Johnson Amy N. 
Published: August 2019

Abstract
Global experiential learning using clinical internships and microsemesters is expanding in nursing as an alternative to full-semester study abroad. When incorporated into the curriculum, students have a broader perspective on global health care issues. For example, students learn historic and cultural concepts that are uniquely Australian while studying diversity in a condensed two-week microsemester. We describe the development and incorporation of global internships and alternative global experiences for undergraduate nursing students.
Behavioural mechanisms underlying the evolution of cooperative burrowing inPeromyscusmice
Authors: Bedford Nicole L. , Weber Jesse N. , Tong Wenfei , Baier Felix , Kam Ariana , Greenberg Rebecca A. , Hoekstra Hopi E. 
Published: August 2019

AbstractWhile some behaviours are largely fixed and invariant, others can respond flexibly to different social contexts. Here, we leverage the unique burrowing behaviour of deer mice (genusPeromyscus) to investigate if and how individuals of three species adapt their behaviour when digging individually versus with partners. First, we find that pairs of mice from monogamous (P. polionotus) but not promiscuous (P. maniculatus, P. leucopus) species cooperatively construct burrows that are approximately twice as long as those dug by individuals and similar in size to burrows found in the wild. However, the length of burrows built byP. polionotuspairs differs: opposite-sex pairs construct longer burrows than same-sex pairs. By designing a novel behavioural assay in which we can observe and measure burrowing behaviour directly, we find that longer burrows are achieved not by changing individual behaviour, but instead because opposite-sex pairs are more socially cohesive and thus more likely to dig simultaneously, which is a more efficient mode of burrow elongation. Thus, across social contexts, individual burrowing behaviour appears largely invariant, even when the resultant burrow from pairs of mice differs from expectation based on individual behaviour, underscoring the fixed nature of burrowing behaviour inPeromyscusmice.
Electrochemical Roughening and Carbon Nanotube Coating of Tetrodes for Chronic Single-Unit Recording
Authors: Xia Zifeng , Arias-Gil Gonzalo , Deckert Martin , Vollmer Maike , Curran Andrew , Herrera-Molina Rodrigo , Brosch Marcel , Krug Kristine , Schmidt Bertram , Ohl Frank W. , Lippert Michael T. , Takagaki Kentaroh 
Published: August 2019

AbstractRecording from single neurons in the brain for long periods of time has been a central goal in both basic neuroscience and translational neurology, in order to understand mechanisms underlying brain processes such as learning and to understand the pathogenesis of neurodynamic disease states 1. Recent advances in materials engineering, digital signal acquisition, and analysis algorithms have brought us closer to achieving this goal, and the possibility has gathered much public attention 2,3. However, it remains a challenge to record from the same units for weeks to months. Here, we record many high-quality tetrode neuronal signals reliably over long periods of time in both deep and superficial areas of the brain. We achieve this by combining electrochemical roughening and carbon nanotube coating of a flexible platinum/iridium substrate, with materials, packaging, and insertion optimized to minimize tip movement with brain pulsation. This “Magdeburger” probe enables recordings with long-term signal stability and high signal-to-noise ratio at a reasonable cost in both rodent brains and in substantially larger primate brains. Robust tetrode tracking of identified neurons over longer time periods, in multiple independently targeted areas of the brain, will allow fundamental advances in the study of cognitive learning, aging, and pathogenesis, and opens new possibilities for brain interfaces in humans.
Detection of Enterovirus D68 in wastewater samples from the United Kingdom during outbreaks reported globally between 2015 and 2018
Authors: Majumdar Manasi , Wilton Thomas , Hajarha Yara , Klapsa Dimitra , Martin Javier 
Published: August 2019

ABSTRACTDetection of enterovirus D68 (EV-D68) in wastewater samples from the UK between December 2014 and December 2018 showed a marked seasonal distribution with a high proportion of samples containing EV-D68 during periods when identification of this virus in clinical samples was most common. This includes a recent upsurge of EV-D68 detection in respiratory samples from the United Kingdom between August and December 2018 associated with cases of acute flaccid myelitis, following similar reports in the USA. Phylogenetic analysis of EV-D68 sewage strains demonstrated that strains belonging to distinct genetic clades followed the same temporal distribution as that observed for EV-D68 clinical strains in the UK and that they showed very close genetic relationship with EV-D68 strains circulating elsewhere in the world during the same periods. The results demonstrated a clear association between detecting EV-D68 in wastewater and finding it in clinical samples which was somehow unexpected given that EV-D68 is rarely detected in stool samples. We conclude that the use of environmental surveillance is a valuable tool to detect and monitor outbreaks due to EV-68 infection.
Bayesian semi-nonnegative matrix tri-factorization to identify pathways associated with cancer phenotypes
Authors: Park Sunho , Kar Nabhonil , Cheong Jae-Ho , Hwang Tae Hyun 
Published: August 2019

Accurate identification of pathways associated with cancer phenotypes (e.g., cancer sub-types and treatment outcome) could lead to discovering reliable prognostic and/or predictive biomarkers for better patients stratification and treatment guidance. In our previous work, we have shown that non-negative matrix tri-factorization (NMTF) can be successfully applied to identify pathways associated with specific cancer types or disease classes as a prognostic and predictive biomarker. However, one key limitation of non-negative factorization methods, including various non-negative bi-factorization methods, is their lack of ability to handle non-negative input data. For example, many molecular data that consist of real-values containing both positive and negative values (e.g., normalized/log transformed gene expression data where negative value represents down-regulated expression of genes) are not suitable input for these algorithms. In addition, most previous methods provide just a single point estimate and hence cannot deal with uncertainty effectively.To address these limitations, we propose a Bayesian semi-nonnegative matrix trifactorization method to identify pathways associated with cancer phenotypes from a realvalued input matrix, e.g., gene expression values. Motivated by semi-nonnegative factorization, we allow one of the factor matrices, the centroid matrix, to be real-valued so that each centroid can express either the up- or down-regulation of the member genes in a pathway. In addition, we place structured spike-and-slab priors (which are encoded with the pathways and a gene-gene interaction (GGI) network) on the centroid matrix so that even a set of genes that is not initially contained in the pathways (due to the incompleteness of the current pathway database) can be involved in the factorization in a stochastic way specifically, if those genes are connected to the member genes of the pathways on the GGI network. We also present update rules for the posterior distributions in the framework of variational inference. As a full Bayesian method, our proposed method has several advantages over the current NMTF methods which are demonstrated using synthetic datasets in experiments. Using the The Cancer Genome Atlas (TCGA) gastric cancer and metastatic gastric cancer immunotherapy clinical-trial datasets, we show that our method could identify biologically and clinically relevant pathways associated with the molecular sub-types and immunotherapy response, respectively. Finally, we show that those pathways identified by the proposed method could be used as prognostic biomarkers to stratify patients with distinct survival outcome in two independent validation datasets. Additional information and codes can be found at https://github.com/parks-cs-ccf/BayesianSNMTF.
Expression of oxytocin receptors in the zebra finch brain during vocal development
Authors: Davis Matthew T. , Grogan Kathleen E. , Maney Donna L. 
Published: August 2019

AbstractJuvenile male zebra finches memorize and learn to sing the song of a male caregiver, or “tutor”, during a complex vocal learning process. Juveniles are highly motivated to interact socially with their tutor, and these interactions are required for effective vocal learning. It is currently unknown what neurological mechanisms underlie attraction to tutors, but social motivation and affiliation in this and other species may be mediated by oxytocin and related nonapeptides. Here, we used qPCR to quantify expression of oxytocin receptor (OTR) mRNA in the lateral septum, auditory forebrain, and regions of the song control system in zebra finches throughout post-hatch development and vocal learning. We found that zebra finches express OTR mRNA in these regions from post-hatch day 5 to adulthood, encompassing the entire period of auditory and sensorimotor learning. We also mapped the binding of 125I-ornithine vasotocin, an oxytocin receptor antagonist that binds to oxytocin receptors in songbird brain, to understand the neuroanatomical distribution of oxytocin-like action during vocal development. This study provides the groundwork for the use of zebra finches as a model for understanding the mechanisms underlying social motivation and its role in vocal development.
Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics
Authors: Baumert P. , Temple S. , Stanley J.M. , Cocks M. , Strauss J.A. , Shepherd S.O. , Drust B. , Lake M.J. , Stewart C.E. , Erskine R.M. 
Published: August 2019

ABSTRACTHamstring muscle injury is highly prevalent in sports involving repeated maximal sprinting. Although neuromuscular fatigue is thought to be a risk factor, the mechanisms underlying the fatigue response to repeated maximal sprints are unclear. Here, we show that repeated maximal sprints induce neuromuscular fatigue accompanied with a prolonged strength loss in hamstring muscles. The immediate hamstring strength loss was linked to both central and peripheral fatigue, while prolonged strength loss was associated with indicators of muscle damage. The kinematic changes immediately after sprinting likely protected fatigued hamstrings from excess elongation stress, while larger hamstring muscle physiological cross-sectional area and lower myoblast:fibroblast ratio appeared to protect against fatigue/damage and improve muscle recovery within the first 48 h after sprinting. We have therefore identified novel mechanisms that likely regulate the fatigue/damage response and initial recovery following repeated maximal sprinting in humans.
Constrution of a genetic map of rils derived from wheat (T. aestivumL.) varieties pamyatii azieva x paragon using high-throughput snp genotyping platform kasp -competative allele specific PCR
Authors: Yermekbayev K , Griffiths S , Chettry M , Liverington-Waite M , Orford S , Amalova A , Abugalieva S , Turuspekov Y 
Published: August 2019

AbstractThe main purposes of the study were i) to develop a first mapping population for bread wheat grown in Kazakhstan, ii) to construct its genetic map for further identification of genes associated with important agronomic traits.To the best of our knowledge this is the first segregating population and genetic map developed for Kazakh bread wheat. The work is an example of how plant breeding programs in Kazakhstan have started successfully deploying next generation plant breeding methods.The KASP (Compatative Allele Specific PCR) technology of LGC Group and SNP DNA-markers have been exploited to genotype and build a genetic map of the segregating population. The total length of the map was 1376 cM. A total 157 out of initial 178 SNP markers used formed 26 linkage groups leaving 1 duplicated and 20 unassigned markers. The threshold distance between markers was set ≤ 30 cM. Therefore, two linkage groups were obtained for chromosomes such as 2A, 2B, 2D, 3A, 5A, 6B and 7A. Despite one duplicated and 20 unassigned markers, the 157 KASP SNP markers that were mapped spanned A, B and D genomes of wheat. Kosambi Mapping function was employed to calculate recombination units between makers. RILs were developed through SSD method up to F4 generation. Almost 97% of identified alleles were useful in evaluating the population’s genetic diversity; the remaining 3% showed no outcome. As a result, 77 DNA markers were mapped for A, 74 for B and 27 for D genomes. The mapping population will be genotyped using high marker density array planform such as Illumina iSelect to obtain a genetic map with a relatively high coverage. Then, the population and high-resolution genetic map will be used to identify genes influencing wheat adaptation in Kazakhstan.
An ultrasensitive T-cell receptor detection method for TCR-Seq and RNA-Seq data
Authors: Chen Si-Yi , Zhang Qiong , Liu Chun-Jie , Guo An-Yuan 
Published: August 2019

AbstractT-cell receptors (TCRs) recognizing antigens play vital roles in T-cell immunology. Surveying TCR repertoires by characterizing complementarity-determining region 3 (CDR3) can provide valuable insights into the immune community underlying pathologic conditions, which will benefit neoantigen discovery and cancer immunotherapy. Here we present a novel tool named CATT, which can apply on TCR sequencing (TCR-Seq), RNA-Seq, and single-cell TCR(RNA)-Seq data to characterize CDR3 repertoires. CATT integrated maximum-network-flow based micro-assembly algorithm, data-driven error correction model, and Bayes classification algorithm, to self-adaptively and ultra-sensitively characterize CDR3 repertoires with high accuracy. Benchmark results of datasets from in silico and real conditions demonstrated that CATT showed superior recall and precision compared with other prevalent tools, especially for datasets with short read length and small data size. By applying CATT on a TCR-Seq dataset from aplastic anemia patients, we found the skewing of TCR repertoire was due to the oligoclonal expansion of effector memory T-cells. CATT will be a powerful tool for researchers conducting TCR and immune repertoire studies. CATT is freely available at http://bioinfo.life.hust.edu.cn/CATT.
The sodium leak channel complex is modulated by voltage and extracellular calcium
Authors: Chua Han Chow , Wulf Matthias , Weidling Claudia , Rasmussen Lise Pilgaard , Pless Stephan Alexander 
Published: August 2019

SummaryThe sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations are life-threatening in humans and knockout is lethal in mice. However, the basic functional and pharmacological properties of NALCN have remained elusive. Here, we found that the robust function of NALCN in heterologous systems requires co-expression of UNC79, UNC80 and FAM155A. The resulting NALCN channel complex is constitutively active, conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations. Our data support the notion that NALCN is directly responsible for the increased excitability observed in a variety of neurons in reduced extracellular Ca2+. Despite the smaller number of voltage-sensing residues in the putative voltage sensors of NALCN, the channel complex shows voltage-dependent modulation of the constitutive current, suggesting that voltage-sensing domains can give rise to a broader range of gating phenotypes than previously anticipated. Our work points towards formerly unknown contributions of NALCN to neuronal excitability and opens avenues for pharmacological targeting.HighlightsFunction of NALCN requires UNC79, UNC80 and FAM155AThe complex is permeable to monovalent cations, but is blocked by divalent cationsThe complex displays a constitutively active, voltage-modulated current phenotypePositively charged side chains in S4 of NALCN VSD I and II confer voltage sensitivity
Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling via FAT1
Authors: Xu Jiuzhi , Tang Yang , Sheng Xiaole , Tian Yuhua , Deng Min , Du Sujuan , Lv Cong , Song Yongli , Lou Pengbo , Luo Yongting , Li Yuan , Zhang Bing , Chen Yanmei , Liu Zhanju , Cong Yingzi , Plikus Maksim V. , Meng Qingyong , Zhou Zhaocai , Yu Zhengquan 
Published: August 2019

AbstractThe YAP signaling activation in epithelial cells is essential for intestinal regeneration and tumorigenesis. However, the molecular mechanism linking stromal signals to YAP-mediated intestinal regeneration and tumorigenesis is poorly defined. Here we report a stroma-epithelia YAP signaling axis essential for stromal cells to modulate epithelial cell growth during intestinal regeneration and tumorigenesis. Specifically, upon inflammation and in cancer, an oncogenic transcription factor ETS1 in stromal cells induces expression of a secreted protein ISLR that can directly binds to a transmembrane protocadherin FAT1 on the surface of epithelial cells. This binding suppressed the Hippo signaling by disrupting MST1-FAT1 association, resulting in YAP signaling activation. Deletion of Islr in stromal cells in mice markedly impaired intestinal regeneration, and suppressed tumorigenesis in the colon. Moreover, the expression of stromal cell-specific ISLR and ETS1 significantly increased in inflamed mucosa of human IBD patients and in human colorectal adenocarcinoma, accounting for the epithelial YAP hyperactivation. Collectively, our findings uncovered a molecular mechanism governing signals for communication between stroma and epithelium during tissue regeneration and tumorigenesis.