bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corticosteroid-associated lupus pancreatitis: a case series and systematic review of the literature
Authors: Dwivedi P , Kumar R R , Dhooria A , Adarsh M B , Malhotra S , Kakkar N , Naidu S , Sharma S K , Sharma A , Jain S , Dhir V 
Published: April 2019

Background Acute pancreatitis is an uncommon complication that occurs in 0.85% to 4% of patients with systemic lupus erythematosus (SLE). In some patients, it occurs within days to weeks of starting medium-to-high dose corticosteroids. The authors have used the term ‘corticosteroid-associated lupus pancreatitis’ for these patients, and they report a case series and perform a systematic review of previously published reports. Methods For the purpose of this study, corticosteroid-associated lupus pancreatitis was defined as occurrence of acute pancreatitis in patients with SLE (fulfilling the 1997 ACR), within 3 weeks of starting therapy with medium-to-high dose corticosteroids – either newly initiated or escalated from a lower dose. All patients with SLE admitted in the last 2.5 years in a North Indian university hospital were reviewed, and those with pancreatitis who fulfilled the above criteria were included in the case series. For the systematic review, a PUBMED search using the keywords ‘lupus’ and ‘pancreatitis’ was performed, and reports in English were reviewed for an association with corticosteroids. Results Among 420 admissions of SLE patients, six patients (1.4%) fulfilled criteria for corticosteroid-associated lupus pancreatitis. All were female, with mean age and disease duration of 19.7 ± 3.3 and 3.8 ± 2.5 years respectively. All had active disease and developed acute pancreatitis within 48–72 hours of newly initiating medium-to-high dose corticosteroids (in three patients) or escalating them to medium–high dose (in three patients). After the development of pancreatitis, corticosteroids were continued in all except one patient. In addition, two patients received pulse methylprednisolone, two received pulse cyclophosphamide and one was started on azathioprine. Three patients died during hospitalization, all with severe pancreatitis. On systematic review, among 451 cases of lupus pancreatitis reported, 23 (5%) fulfilled criteria for ‘corticosteroid-associated lupus pancreatitis’. A majority of them had pancreatitis within 3 days of starting treatment with medium-to-high dose corticosteroids. The mortality in these patients was 37.5%. Conclusion In a small but substantial proportion of patients with lupus who develop pancreatitis, it occurs within days to weeks of starting medium-to-high dose corticosteroids. Many of these patients continue to receive corticosteroids, and some receive more aggressive immunosuppression. However, they have significant mortality, and further studies are required to identify appropriate treatment in this subgroup of patients.
Extraarticular Supramalleolar Osteotomy in Asymmetric Varus Ankle Osteoarthritis
Authors: Krähenbühl Nicola , Akkaya Mahmut , Deforth Manja , Zwicky Lukas , Barg Alexej , Hintermann Beat 
Published: April 2019

Background: In recent years, supramalleolar osteotomy has become a valuable alternative for treatment of ankle osteoarthritis. The aim of this study was to investigate whether the preoperative stage of ankle osteoarthritis or tilt of the talus in the ankle mortise impacts radiologic and clinical outcomes following a supramalleolar osteotomy. Methods: Forty-four patients who underwent a supramalleolar osteotomy for posttraumatic asymmetric varus ankle osteoarthritis were included. Subgroups were formed according to the preoperative stage of ankle osteoarthritis and the tilt of the talus in the ankle mortise. The radiographic and clinical outcomes of each subgroup were compared, and survival rates calculated. Results: Ankles with a preoperative Takakura stage of 2 and 3a showed a significant higher survival rate at 5 years (88% [95% CI, 67-100] and 93% [95% CI, 80-100]) compared with ankles with a preoperative Takakura stage of 3b (47% [95% CI, 26-86]; P = .044). The 5-year survival rate for patients with a preoperative tilt of the talus in the ankle mortise of 4-10 degrees was 85% (95% CI, 68-100), while patients with a preoperative tilt of >10 degrees showed a 5-year survival rate of 65% (95% CI, 46-93; P = .117). Conclusion: Supramalleolar osteotomy was a valuable treatment option for early to mid-stage posttraumatic asymmetric varus ankle osteoarthritis. Level of Evidence: Level IV, retrospective cohort study.
Landing Kinematics and Isometric Hip Strength of Individuals With Chronic Ankle Instability
Authors: McCann Ryan S. , Terada Masafumi , Kosik Kyle B. , Gribble Phillip A. 
Published: April 2019

Background: Chronic ankle instability (CAI) is associated with hip strength deficits and altered movement in the lower extremity. However, it remains unclear how hip strength deficits contribute to lateral ankle sprain (LAS) mechanisms. We aimed to compare lower extremity landing kinematics and isometric hip strength between individuals with and without CAI and examine associations between hip kinematics and strength. Methods: Seventy-six individuals completed 5 single-leg landings, during which we collected three-dimensional ankle, knee, and hip kinematics from 200 milliseconds pre–initial contact to 50 milliseconds post–initial contact. We calculated average peak torque (Nm/kg) from 3 trials of isometric hip extension, abduction, and external rotation strength testing. One-way analyses of variance assessed group differences (CAI, LAS coper, and control) in hip strength and kinematics. Pearson product moment correlations assessed associations between hip kinematics and strength. We adjusted the kinematic group comparisons and correlation analyses for multiple comparisons using the Benjamini-Hochberg method. Results: The CAI group exhibited less hip abduction during landing than LAS copers and controls. The CAI group had lower hip external rotation strength than LAS copers ( P = .04, d = 0.62 [0.05, 1.17]) and controls ( P < .01, d = 0.87 [0.28, 1.43]). Effect sizes suggest that the CAI group had deficits in EXT compared with controls ( d = 0.63 [0.06, 1.19]). Hip strength was not associated with hip landing kinematics for any group. Conclusion: Altered landing mechanics displayed by the CAI group may promote mechanisms of LAS, but they are not associated with isometric hip strength. However, hip strength deficits may negatively impact other functional tasks, and they should still be considered during rehabilitation. Level of Evidence: Level III, case-control study.
The effects of Rituximab on Graves’orbitopathy: A retrospective study of 14 patients
Authors: Eid Laura , Coste-Verdier Valentine , Longueville Eric , Ribeiro Emmanuel , Nicolescu-Catargi Bogdan , Korobelnik Jean-François 
Published: April 2019

Purpose: Management of Graves’ ophthalmopathy remains challenging. Over the last decade, previous studies have shown promising results for Rituximab in the treatment of Graves’ ophthalmopathy. We present the response of 14 individuals with active moderate-to-severe Graves’ ophthalmopathy to Rituximab, representing one of the largest retrospective case series reported to date. Methods: Rituximab was administered intravenously, 1000 mg twice at a 2-week interval. The primary end point was a clinical activity score reduction (improvement by ⩾ 2 points or disease inactivation: clinical activity score < 3) at 24 weeks. Secondary end points included clinical activity score improved by ⩾ 2 points or inactivation of Graves’ ophthalmopathy at 12 weeks, improvement in each item of the clinical activity score, in proptosis, in severity disease by the total eye score and in diplopia according to the Gorman score. Results: A limited improvement in clinical activity score was observed (median improvement at 24 weeks by 1 point, p = 0.002, (5/14 patients, 35.7%). Disease inactivation occurred in 50% of patients (7/14 patients). At 12 weeks, clinical activity score improved by ⩾ 2 points in 2/14 patients (14.3%) and inactivation of Graves’ ophthalmopathy occurred in four patients (28.6%). Improvement in proptosis and total eye score was observed in 3/9 patients (33%) and in 4/14 patients (28.6%) at 24 weeks, respectively. Only one patient experienced moderate adverse event. Conclusion: Rituximab is a well-tolerated treatment with a good safety profile, but offered limited and partial improvement for active moderate-to-severe Graves’ ophthalmopathy with a long duration of disease.
Factors influencing myopic shift in children after intraocular lens implantation
Authors: Valeina Sandra , Heede Santa , Erts Renars , Sepetiene Svetlana , Skaistkalne Elina , Radecka Liga , Vanags Juris , Laganovska Guna 
Published: April 2019

Introduction: Intraocular lenses have always been a controversial topic in pediatric cataract surgery. In the early 1990s in the post-Soviet states of Eastern Europe, intraocular lenses promised an easier full-time correction and amblyopia treatment. Since 1991, ophthalmologists in Latvia have been implanting intraocular lenses in infants. Amount of the postoperative myopic shift and its influencing factors, analyzed in this article, are important indicators of congenital cataract treatment. Materials and methods: A retrospective chart review off 85 children (137 eyes) who underwent foldable posterior chamber intraocular lens implantation at the Clinical University Hospital in Riga, Latvia, from 1 January 2006 until 31 December 2016, was performed. Depending on the age at surgery, patients were divided into six groups: 1–6, 7–12, 13–24, 25–48, 49–84, and 85–216 months. Results: The largest and more variable myopic shift was found in a group of diffuse/total and nuclear cataract with surgery before the age of 6 months. There was a statistically significant correlation between the acquired best-corrected visual acuity and the amount of myopic shift (rs = 0.33; p < 0.001). Comparing the amount of myopic shift in two groups of different intraocular lens implantation target refraction tactics, we did not find statistically significant differences. Comparing the amount of myopic shift and implanted intraocular lens power, a negative, statistically significant correlation was found. Conclusion: The earlier the cataract extraction surgery and intraocular lens implantation is performed, the larger the myopic shift. The morphological type of cataract, best-corrected visual acuity, secondary glaucoma, and intraocular lens power influence the amount of myopic shift.
Predictors of High Program Exposure Among Adolescents Participating in a Smoking Prevention Intervention in Romania
Authors: Nădăşan Valentin , Ferencz Loránd , Ábrám Zoltán , Foley Kristie 
Published: April 2019

Introduction: Web-based smoking prevention programs can be delivered to large groups of adolescents under relatively private conditions at a convenient cost, but their effectiveness is highly dependent on the level of exposure to the educational content. The objective of the study was to identify the predictors of high program exposure among a group of adolescents participating in a web-based smoking prevention cluster randomized trial in Romania. Methods: The study sample included 675 adolescents from Târgu Mureş, Romania. The level of exposure to the ASPIRE web-based smoking prevention program was monitored using data automatically saved on the system server. High program exposure was defined as watching 75% to 100% of the educational content. Associations between adolescents’ sociodemographic, psychological, and behavioral variables collected online at the beginning of the intervention and high program exposure were tested using chi-square test and logistic regression. Results: In all, 68.3% of students were highly exposed to the program. There were 4 significant predictors of high program exposure in the multivariable logistic regression model: participant’s father’s lower level of education (odds ratio [OR]: 1.75; 95% confidence interval [CI]: 1.19-2.44), participant’s brother’s nonsmoking status (OR: 1.76; 95% CI: 1.13-2.72), never trying e-cigarettes (OR: 1.73; 95% CI: 1.22-2.45), and considering the health of others an important reason not to smoke (OR: 2.46; 95% CI: 1.54-3.93). Conclusions: The analysis identified sociodemographic, psychological, and behavioral factors that may be useful in project management of such intervention to improve program effectiveness.
Elevated levels of circulating microvesicles in coronary artery disease patients with type 2 diabetes and albuminuria: Effects of exercise training
Authors: Bratseth Vibeke , Chiva-Blanch Gemma , Byrkjeland Rune , Solheim Svein , Arnesen Harald , Seljeflot Ingebjørg 
Published: April 2019

Objective: Circulating microvesicles, released from activated/apoptotic cells, are involved in vascular complications and may be looked upon as biomarkers. Albuminuria is characteristic of disease progression in type 2 diabetes mellitus. We aimed to investigate quantitative and qualitative differences of circulating microvesicles in type 2 diabetes mellitus with and without albuminuria and whether 12-month exercise training influenced expression of circulating microvesicles. Methods: Coronary artery disease patients with type 2 diabetes mellitus (n = 75), of which 25 had albuminuria, were included. Annexin V+ (AV+) circulating microvesicles were analysed by flow cytometry in citrated plasma. The exercise volume was 150 min per week. Results: In albuminuria patients, circulating microvesicles from endothelial-(CD146+/CD62E+/AV+) and endothelial-progenitor-(CD309+/CD34+/AV+) cells were significantly higher compared to those without ( p ⩽ 0.01, both). Receiver operating characteristic curve analysis of the endothelial circulating microvesicles shows an area under the curve of 0.704 (95% confidence interval: 0.57–0.84; p = 0.004). Albuminuria patients had more circulating microvesicles derived from activated leukocytes and monocytes and monocytes carrying tissue factor (CD11b+/AV+, CD11b+/CD14+/AV+, CD142+/CD14+/AV+, respectively, p ⩽ 0.05, all) and higher number of circulating microvesicles from activated platelets (CD62P+/AV+). Within exercising patients, circulating microvesicles from progenitor cells increased ( p = 0.023), however, not significantly different from controls. Conclusion: Coronary artery disease patients with type 2 diabetes mellitus and albuminuria had elevated number of circulating microvesicles from activated blood and vascular cells, rendering them as potential predictors of disease severity. The circulating microvesicles were limitedly affected by long-term exercise training in our population.
From Caries Progression and Restoration Failures to Periapical Lesions in the Era of Precision
Authors: Leonardi D.P. , Vieira A.R. 
Published: April 2019

Knowledge Transfer Statement: Dental research can be thought of as a continuum of clinical observations that are dissected in the laboratory with answers that can be brought back to the clinic to change patient management. We believe this is the case for the use of adhesive systems and outcomes of dental treatment. Clinical observations related to negative outcomes have been tested in the laboratory and solutions have been proposed, with more precise implementation of these solutions possible when genomic approaches are added. Here we elaborate on this process based on the observations that lead to an attempt to inactivate metalloproteinase activity by dentin crosslinking.
Ophthalmic Artery Occlusion and Subsequent Retinal Fibrosis From a Calcium Hydroxylapatite Filler Injection
Authors: Oh Daniel J. , Jiang Yi , Mieler William F. 
Published: April 2019

Purpose: We report a case of an otherwise healthy 48-year-old woman presenting with acute vision loss after injection of a soft-tissue filler in the glabellar region with calcium hydroxylapatite microspheres (Radiesse, Merz North America, Inc) with 9 months of follow-up. Methods: Fundus photographs and spectral-domain optical coherence tomography (SD-OCT) were obtained at presentation, at 4 months of follow-up, and at 9 months of follow-up. Results: Acutely, the retina was characterized by significant pallor and thickening but evolved into diffuse retinal fibrosis and atrophy. The patient had no light perception at presentation and did not recover any visual function. Conclusions: Few case reports have described calcium hydroxylapatite filler injections leading to orbital and ocular complications. This is the first case report illustrating dense fibrotic and atrophic retinal changes on fundus photography, fluorescein angiography, and SD-OCT. While various facial fillers have been reported to have serious ocular consequences, we illustrate the acute and subsequent sequelae of an ophthalmic artery occlusion from calcium hydroxylapatite microspheres.
Clinical Effectiveness of Switching Between Ranibizumab and Aflibercept in Treatment of Neovascular AMD: US Real-World Outcomes
Authors: Dugel Pravin U. , Griner Raymond , Ferreira Alberto , Milnes Fran , Lotery Andrew J. 
Published: April 2019

Purpose: The purpose of this article is to examine visual acuity (VA) outcomes and treatment patterns in neovascular age-related macular degeneration (nAMD) eyes switching between ranibizumab and aflibercept in routine clinical practice. Methods: Electronic medical records were used to identify nAMD eyes receiving ranibizumab or aflibercept with 12 months’ follow-up since switching antivascular endothelial growth factor (anti-VEGF) therapy. The primary outcome compared mean change in VA between switch and Month 12 to test the noninferiority of switching from ranibizumab to aflibercept vs aflibercept to ranibizumab. Comparing the number of injection/noninjection visits was the key secondary objective. Results: A total of 269 eyes switching from ranibizumab to aflibercept and 83 switching from aflibercept to ranibizumab were included. The mean change in VA (letters) after 12 months in eyes switched from ranibizumab to aflibercept, and from aflibercept to ranibizumab, was –1.56 and 0.21, respectively ( P = .65). The adjusted difference (95% confidence interval) of mean change at Month 12 was 1.29 (–2.97 to 5.55; P = .55), confirming the noninferiority of ranibizumab. The mean (±SD) number of injections during follow-up was 8.67 (±2.63) for eyes switching from aflibercept to ranibizumab and 7.79 (±2.77) for ranibizumab to aflibercept ( P = .01). Conclusions: Switching between anti-VEGFs is not associated with clinically relevant differences in VA at 12 months in routine clinical practice.
GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73
Authors: Lalioti Maria-Eleni , Arbi Marina , Loukas Ioannis , Kaplani Konstantina , Kalogeropoulou Argyro , Lokka Georgia , Kyrousi Christina , Mizi Athanasia , Georgomanolis Theodore , Josipovic Natasa , Gkikas Dimitrios , Benes Vladimir , Politis Panagiotis K. , Papantonis Argyris , Lygerou Zoi , Taraviras Stavros 
Published: April 2019

ABSTRACT
A distinct combination of transcription factors elicits the acquisition of a specific fate and the initiation of a differentiation program. Multiciliated cells (MCCs) are a specialized type of epithelial cells that possess dozens of motile cilia on their apical surface. Defects in cilia function have been associated with ciliopathies that affect many organs, including brain and airway epithelium. Here we show that the geminin coiled-coil domain-containing protein 1 GemC1 (also known as Lynkeas) regulates the transcriptional activation of p73, a transcription factor central to multiciliogenesis. Moreover, we show that GemC1 acts in a trimeric complex with transcription factor E2F5 and tumor protein p73 (officially known as TP73), and that this complex is important for the activation of the p73 promoter. We also provide in vivo evidence that GemC1 is necessary for p73 expression in different multiciliated epithelia. We further show that GemC1 regulates multiciliogenesis through the control of chromatin organization, and the epigenetic marks/tags of p73 and Foxj1. Our results highlight novel signaling cues involved in the commitment program of MCCs across species and tissues.
This article has an associated First Person interview with the first author of the paper.
HIV, syphilis and hepatitis B coinfections in Mkushi, Zambia: a cross-sectional study
Authors: Katamba Cibangu , Chungu Theresa , Lusale Chisali 
Published: April 2019

Background: Human immunodeficiency virus, syphilis and hepatitis B virus (HBV) are major global public health problems. They are sexually transmitted diseases with overlapping modes of transmission and affected populations. The aim of this study is to assess the seroprevalence of HIV 1, hepatitis B virus and syphilis coinfections among newly diagnosed HIV individuals aged 16 to 65 years, initiating on antiretroviral therapy, in Mkushi, Zambia. Methods: A total number of 126 sera were collected from HIV 1 infected patients attending Mkushi district hospital/ART clinic for antiretroviral therapy initiation. Hepatitis B surface antigen test and serologic test for syphilis were conducted between March and May 2018. Results: Of the 126 participants, hepatitis B surface antigen (HBsAg) was detected with a prevalence of 9.5% among newly diagnosed HIV infected patients, while that of syphilis was as high as 40.5% in this same population group. Three patients recorded HIV coinfections with both syphilis and hepatitis B virus (2.4%) at the same time. After analysis, the results indicate that there was no significant association between gender for both dependent variables: HIV/syphilis or HIV/hepatitis B virus coinfections (alpha significance level > 0.05). Those who had a history of syphilis infection in the past were more likely than those who had none to be HIV-syphilis coinfected (53.6% vs 34%, respectively; odd ratio [OR] 2.236; 95% confidence interval [CI] 1.045 – 4.782). Conclusion: The high prevalence rates for HIV, HBV, and syphilis coinfections strongly indicate the need for HBV and syphilis screening for HIV infected individuals. Furthermore, the high number of patients previously treated for syphilis who retest positive for syphilis in this study calls for use of the Venereal Disease Research Laboratory test to identify true syphilis infection (titers ≥ 1:8 dilutions, strongly suggestive).
Human aldose reductase unfolds through an intermediate.
Authors: Sekhon Gurprit , Singh Ranvir 
Published: April 2019

Background: Human aldose reductase (hAR) converts glucose to sorbitol under hyperglycemic conditions. Aldose reductase is first and rate limiting enzyme of polyol pathway. Under hyperglycemia, increased flux of glucose through this pathway has been implicated in development of secondary complication in diabetes. Due to this clinical implication, aldose reductase attracted considerable attention from drug discovery perspective. In spite of extensive characterization of the biochemical and structural context, little is known about the unfolding behavior of aldose reductase. This study reports equilibrium unfolding studies of human aldose reductase. Methods: We carried out thermal and chemical induced equilibrium unfolding studies of human aldose reductase monitored by circular dichroism and tryptophan and ANS fluorescence spectroscopy. Results: Thermal unfolding studies present a classical picture of two state unfolding from native to unfolded state. The data was used to derive thermodynamic parameters and study thermostability of aldose reductase. Urea and GuHCl induced equilibrium unfolding studies led us to discover an intermediate state, which gets populated at 3.5-4.0 M and 0.7-2 M of urea and GuHCl, respectively. Thermodynamic parameters from chemical induced unfolding are in agreement with those obtained from thermal unfolding. Conclusion: This study revealed that aldose reductase unfolds from native to unfolded state via an intermediate. Assessment of thermodynamic stability of native, intermediate and unfolded state shows that three states are separated by significant energy barriers that ensure cooperativity of unfolding. As hAR functions in cells which are under osmotic and oxidative stress, these in vitro findings may have implications for its native conformation under physiological state.