bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EFFECT OF SCARIFICATION ON ARTICULAR CARTILAGE IN THE RABBIT
Authors: Meachim G. 
Published: February 2018

1. The changes resulting from superficial scarification of articular cartilage have been observed in the knee joint of adult rabbits. A reduction in the amount of stainable matrix ground substance occurred at the sites of damage. Particular attention was therefore paid to sulphated mucopolysaccharide synthesis by cartilage cells in or near the traumatised areas. 2. The femoral groove cartilage one week after scarification showed evidence of increased mucopolysaccharide synthesis, especially by the more superficial chondrocytes near the cuts, but three or four weeks later the enhanced chondrocyte activity tended to diminish, and after six weeks the superficial cells near the cuts were found to be inactive. From six to thirty-four weeks the loss of stainable ground substance extended more deeply, but cell degeneration in these deeper areas of matrix depletion was preceded by a period in which many of the deeper chondrocytes still showed evidence of active mucopolysaccharide synthesis. Cellular activity in tags of depleted cartilage was usually lost before the tags finally disintegrated. Chondrocyte clusters were often seen in the scarified areas, especially in the deeper zones. They seemed to be a reactive rather than degenerative phenomenon. 3. In the scarified cartilages of the patella examined after one week a reactive response by superficial chondrocytes was less evident than in the femoral cartilage from the same joint, and after six weeks areas of deeply extending matrix loss were exceptional. 4. The structural and functional changes in the rabbits' femoral articular cartilage after its scarification resembled those which have been observed in the developing cartilage lesion of human osteoarthritis–namely, loss of interstitial matrix and superficial fibrillation, a stimulated synthesis of chondroitin sulphate by the chondrocytes, and the appearance of cell clusters in the deeper zones. Within the period of the experiment, up to thirty-four weeks, the joint lesions remained strictly localised to the traumatised areas ofcartilage, and exposure of bone and joint remodelling, which are features of advanced osteoarthritis in man, were not seen.
THE ETIOLOGY OF SPONDYLOLISTHESIS
Authors: Newman P. H. , Stone K. H. 
Published: February 2018

1. During a fifteen-year period a clinical, radiological and in some cases a surgical study has been made of 319 patients suffering from spondylolisthesis–that is, forward slipping of one lumbar vertebra on another or forward sagging of the whole lumbar spine in relation to the sacrum. 2. The five etiological factors are described, and the cases are assigned to five groups according to the factor responsible for the slip. In every case slipping is permitted by a lesion of the apparatus which normally resists the forward thrust of the lower lumbar spine–that is, the hook of the neural arch composed of the pedicle, the pars interarticularis and the inferior articular facet engaging caudally over the superior articular facet of the vertebra below. 3. In Group I (congenital spondylolisthesis–sixty-six cases) the lesion is a congenital defect of the facets. In Group II (spondylolytic spondylolisthesis–164 cases) the lesion occurs in the region of the pars interarticularis and is either an elongation of the bone or a break in continuity. There are reasons for thinking that the lesion is caused by stress over a long period rather than by acute injury or by a congenital anomaly of ossification. In Group IV (degenerative spondylolisthesis–eighty cases) the lesion of the facets is degenerative. There are no good grounds for thinking that an abnormality of the angle between the facets and the pedicles is the primary lesion behind the degenerative change. 4. Group III and V comprise few cases. In the former (traumatic spondylolisthesis–three cases) the lesion–a fracture of the neural arch–is caused by a single severe injury. In Group V (pathological spondylolisthesis–six cases) the slipping is caused by weakness of bone from various causes. 5. A full description is given of the etiological and biomechanical features of each group. A special investigation has been made into the etiological factors in degenerative spondylolisthesis. 6. The incidence of involvement of nerve tissues is highest in degenerative spondylolisthesis; the most severe degrees of slip are found in congenital spondylolisthesis.
TREATMENT OF INTRACAPSULAR FRACTURES OF THE FEMORAL NECK WITH THE CHARNLEY COMPRESSION SCREW
Authors: Hargadon E. J. , Pearson J. R. 
Published: February 2018

1. A series of 100 intracapsular fractures of the femoral neck treated with the Charnley compression screw is reported. 2. There were six deaths, and in patients reviewed long enough (seventy-five) there were eleven undisplaced fractures, with successful union in 8l·8 per cent, and sixty-four displaced fractures, with a union rate of 59·6 per cent. 3. If we exclude six failures of operative technique, there remain fifty-eight patients in whom the fracture was judged radiologically to have united in 65·5 per cent. 4. The Charnley compression screw is an effective method of internal fixation in such fractures, and non-union with this method is usually due to causes other than mechanical failure.
CONGENITAL PSEUDARTHROSIS OF THE CLAVICLE
Authors: Alldred A. J. 
Published: February 2018

1. Congenital pseudarthrosis of the clavicle is described. 2. The distinction from cranio-cleido-dysostosis and from birth fracture is stressed. 3. Details are given of two patients reported in the literature and a further nine patients are described. 4. The embryology, natural history and treatment of the condition are discussed.
RADIO-ULNAR FUSION FOR DEFECTS IN THE FOREARM BONES
Authors: Lowe H. G. 
Published: February 2018

1. The problem of gap defects in the forearm bones and its solution by radio-ulnar fusion is discussed. 2. Seven patients with radio-ulnar fusions are presented. In four patients the operation was done for defects in the ulna, in two for defects in the radius, and in one for non-union of the radius and ulna after fracture. 3. The good cosmetic and functional result after radio-ulnar fusion is emphasised.
CONTRACTURE OF THE VASTUS INTERMEDIUS IN CHILDREN
Authors: Gammie W. F. P. , Taylor J. Hermon , Urich H. 
Published: February 2018

1. Two patients are reported with progressive fibrosis of the vastus intermedius muscle causing limitation of flexion of the knee. The first patient, a girl of ten years who was one of binovular twins, noticed difficulty in walking at the age of five, the disability increasing with age. The other girl, aged three, was one of uniovular twins and displayed the abnormality as soon as she started walking. 2. The nature of the condition remains obscure. 3. Surgery is effective, and simple division of the affected muscle segment is recommended. A good range of passive flexion is obtained at once; the active range can be obtained thereafter by physiotherapy. Because this requires the patient's cooperation it is suggested that the best age for surgery is about five or six years.
QUADRICEPSPLASTY
Authors: Nicoll E. A. 
Published: February 2018

1. Thirty cases of stiff knee treated by the operation of quadricepsplasty are reviewed. 2. The causes and morbid anatomy are analysed. The operative technique is based on an appreciation of the latter. 3. The after-care must be meticulous and prolonged. Manipulation under anaesthesia was used after operation in over half the cases. 4. The results were most gratifying. There were two technical failures but in the remaining twenty-eight cases the average gain of fiexion was 68 degrees. In twenty-one of these active extension was full and it was only 5 degrees short in another three. Permanent loss of active extension occurred when the rectus femoris tendon had to be divided or lengthened.
SPONTANEOUS RUPTURE OF THE EXTENSOR POLLICIS LONGUS
Authors: Riddell D. M. 
Published: February 2018

1. Forty-eight patients with spontaneous rupture of the tendon of the extensor pollicis longus have been studied and the results of forty-four operations by tendon transfer are reported. 2. The etiology and the pathology of the condition are discussed. 3. Transfer of the extensor indicis in general gives a better result than transfer of the extensor carpi radialis longus, but each method has its advantages and disadvantages. 4. The best results are obtained when the suture is done so as to leave the tendon in the fullest degree of tension obtainable.
TYPHOID SPINE IN A NIGERIAN WITH SICKLE HAEMOGLOBIN
Authors: Walker Geoffrey F. 
Published: February 2018

1. A proven case of typhoid spine in a patient with sickle cell trait (AS) is recorded. It responded well to conservative treatment with chloramphenicol. 2. The literature on typhoid spine is briefly reviewed and the relationship between salmonella osteomyelitis and sickle cell disease is discussed.
BENNETT'S FRACTURE
Authors: Spêngberg Olle , Thorén Lars 
Published: February 2018

A method of treatment of Bennett's fracture is described. A Kirschner wire is drilled obliquely through the base of the first metacarpal bone and traction is applied in a distal, ulnar and palmar direction in order to counteract the dislocating action of abductor pollicis longus and the flexor muscles. The advantages of the method are: 1) It is technically easy and practically without complications. No important structures are liable to be damaged. 2) It can be used in those cases where the palmar fragment is very small. 3) It can be used for comminuted fractures. 4) It can be used in neglected cases where malunion has occurred. 5) It can be used when there are other fractures of the first metacarpal or adjacent bones. 6) It allows exercises of all the finger joints during the whole period of treatment.
DISCITIS
Authors: Menelaus M. B. 
Published: February 2018

1. Thirty-five children suffering from a mild illness with narrowing of an intervertebral disc have been studied. 2. Backache was the presenting symptom in only a small proportion of children, vague aching in the legs being almost as common at the onset. 3. Stiffness of the affected part of the spine is often present, but there may be no abnormal signs in the back. 4. Radiographs reveal a narrowed disc space with adjacent bony changes. There is usually progressive narrowing of the disc space which may go on to fusion of the affected vertebrae. Less commonly there is reconstitution of the affected disc. 5. The symptoms and signs quickly subside with immobilisation in recumbency and this treatment should be continued until the blood sedimentation rate returns to normal. 6. Adults who have suffered from discitis in childhood are probably more prone to develop backache. 7. The etiology remains uncertain.
THE RESULTS OF EARLY AND DELAYED INTERNAL FIXATION OF FRACTURES OF THE SHAFT OF THE FEMUR
Authors: Smith J. E. M. 
Published: February 2018

1. The results in 211 fractures of the shaft of the femur in adults treated by internal fixation have been reviewed. 2. A comparison has been made between the effects of early internal fixation within the first six days of injury and delayed fixation. 3. Eighty-five fractures treated by early fixation gave a rate of non-union of 23 per cent; in 126 fractures treated by delayed fixation the rate was 0·8 per cent. 4. Delayed operation is therefore advocated for the majority of femoral shaft fractures for which internal fixation is indicated.
EARLY WEIGHT BEARING AFTER INTERNAL FIXATION OF TRANSCERVICAL FRACTURE OF THE FEMUR
Authors: Abrami George , Stevens Jack 
Published: February 2018

1 . A preliminary report is presented of a clinical trial to compare the results of early and late weight bearing in randomly selected patients of comparable age groups whose displaced femoral neck fractures were treated by internal fixation with a sliding nail-plate. 2. When 124 patients were assessed at three months and 107 at six months after operation there was no significant difference between those who started unguarded weight bearing two weeks after operation and those who avoided weight bearing for three months. 3. Early weight bearing appears to have no harmful effect on the early post-operative stability of this fracture when a sliding nail-plate is used for fixation. 4. Further information is necessary before any conclusion can be reached about the effect of early weight bearing on the ultimate fate of the fracture and of the femoral head. For this reason, and also to increase the numbers of patients in the series, the trial is continuing and the patients are being followed up for a three-year period.
POST-TRAUMATIC OSTEOCHONDRITIS OF THE LOWER TIBIAL EPIPHYSIS
Authors: Robertson D. E. 
Published: February 2018

1 . This case of post-traumatic osteochondritis of the lower tibial epiphysis is important because the condition is rare. 2. The similarity to osteochondritis in other sites dating from a single injury is noted. 3. The ankle joint bears more body weight per surface area of articular cartilage than other weight-bearing joint surfaces. It is of interest that regeneration took place in spite of the fact that the child continued to bear weight and that the joint was immobilised for only two months, beginning four months after the original injury.
CHRONIC PROGRESSIVE DISLOCATION OF THE TALO-NAVICULAR JOINT
Authors: Jacobs Philip 
Published: February 2018

1 . Two cases of chronic progressive dislocation of the talo-navicular joints are discussed. 2. Radiographs are presented showing the development of the lesions over a period of eighteen years. 3. It is thought that the lesion is caused by laxity of ligaments and subsequent osteoarthritic changes.
DUPUYTREN'S DIATHESIS
Authors: Lettin Alan W.F. 
Published: February 2018

1 . An epileptic patient with Dupuytren's contracture of the palms, severe plantar fibromatosis, prominent knuckle pads, periarthritis of the shoulders and hyperplasia of the gums is described. 2. The plantar lesions recurred despite radical excision. The knuckle pads on one hand disappeared after radiotherapy. 3. The association of each of these conditions with epilepsy and with Dupuytren's contracture is reviewed, and it is suggested that the hyperplasia of the gums may be a hitherto unrecognised feature. 4. The characteristic histological appearances of the plantar lesions are described and the risk of confusion with fibrosarcoma is emphasised.
THE PATHOLOGICAL CHANGES IN RATS'S NERVES SUBJECT TO MODERATE COMPRESSION
Authors: Weisl H. , Osborne G. V. 
Published: February 2018

1. A method of constricting sciatic nerves of rats was devised which produced lesions resembling macroscopically and electromyographically those of carpal tunnel and related syndromes. 2. The nerves became swollen and hyperaemic proximal and distal to the constriction. The swellings were largely caused by an accumulation of fluid between the axons, but the axons themselves were also increased in size. 3. This accumulation of fluid was an oedema secondary to a partial obstruction of the vasa nervorum.
AMPUTATION IN FRACTURES OF THE TIBIA
Authors: Hicks J. H. 
Published: February 2018

1. The conservative school of treatment of fractures of the tibia, which bases part of its criticism of internal fixation on the ultimate risk of amputation, does not often publish its own rates of amputation. 2. Statistics from a hospital that treats one-third of closed fractured tibiae and two-thirds of compound fractures by internal fixation are therefore put up as a basis for criticism. 3. Comparisons are made with the few available statistics in the literature of conservative treatment. 4. Almost all of the causes for secondary amputation are now curable and in recent years the number of limbs being saved is increasing.
THE PLACE OF DELAYED INTERNAL FIXATION IN THE TREATMENT OF FRACTURES OF THE LONG BONES
Authors: Lam S. J. 
Published: February 2018

It seems right to draw the following conclusions from this study of the relative merits of early and delayed fixation for fractures of the femoral and tibial shafts. 1. In patients under the age of sixty years with femoral shaft fractures there seems to be a significant improvement in the speed and quality of union when internal fixation is delayed. In patients over the age of sixty years the results of delayed fixation are worse than those of early fixation, and in any case the dangers of prolonged recumbency make the latter method preferable. 2. Delaying fixation for tibial shaft fractures does not affect speed of union or functional result. However, the incidence of non-union in these fractures is reduced by over 50 per cent by delaying fixation. This is a good reason for delaying fixation of this fracture too. Some possible reasons for the improved results after delayed fixation have been discussed.
MIXED SCLEROSING BONE DYSTROPHIES
Authors: Walker Geoffrey F. 
Published: February 2018

1. A Nigerian patient with radiographic features of osteopathia striata, osteopoikilosis and melorheostosis is reported. Also radiographs of a patient from the Radiographic Museum of the Institute of Orthopaedics at the Royal National Orthopaedic Hospital are reproduced because they show a similar mixture of these conditions. 2. lt is probable that a common factor is present at some stage in the development of melorheostosis, osteopathia striata, osteopoikilosis and possibly osteopetrosis.
COMPRESSION ARTHRODESIS OF THE SHOULDER
Authors: Charnley John , Houston James Kirk 
Published: February 2018

1. A series of twenty-three compression arthrodeses of the shoulder are reviewed. 2. The review demonstrates compression arthrodesis to be an excellent method of obtaining bony fusion of the shoulder. 3. The consistent success in achieving arthrodesis, in what is to be considered a difficult joint to fuse, is significant in the theory of compression arthrodesis, because the shoulder offers a more perfect example of compression arthrodesis than the knee in that the element of absolute fixation is less obvious.
DISLOCATIONS OF THE METATARSAL BONE AND ADJACENT TOE
Authors: English T. A. 
Published: February 2018

1. Two cases of an unusual forefoot injury are recorded in which dislocation of the base of a metatarsal bone is associated with, and tends to perpetuate, dislocation of the metatarsophalangeal joint of the adjacent toe. 2. The anatomical and mechanical relationships between these linked dislocations are discussed, as are the principles of treatment. 3. The concept of segmental injuries to the forefoot is introduced.
ON THE QUESTION OF RECURRENCE OF OSTEOCHONDROMA
Authors: Morton K. S. 
Published: February 2018

1. Two cases are reported in which reappearance of an osteochondroma after excision was shown to represent a second independent lesion and not a true recurrence. 2. The significance of this observation is discussed in relation to the pathogenesis and prognosis of this lesion. 3. A plea is made for greater discrimination in using the ominous description "recurrence," because the rare true recurrence must strongly favour a diagnosis of malignancy.
VULNERABILITY OF THE SCIATIC NERVE IN CLOSED ISCHIO-FEMORAL ARTHRODESIS BY NAIL AND GRAFT
Authors: Adams J. Crawford 
Published: February 2018

1. The risk of injury to the sciatic nerve during closed ischio-femoral arthrodesis by nail and graft has been assessed on the basis of clinical evidence and of anatomical studies in the living and in cadavers. 2. The margin of safety for the nerve is nearly always small. 3. The risk of injury to the nerve is prohibitive when there is marked deformity or hypoplasia of the pelvis. The risk is also increased when the buttock is compressed against the table and, because of the technical difficulties that are entailed, when the hip is in marked flexion. The risk is probably greater in children than in adults. 4. In properly selected cases in which none of these adverse factors is present it is submitted that the risk of nerve injury can be eliminated by proper attention to surgical technique and by the observance of certain definite precautions. 5. When there is doubt in the surgeon's mind about his ability to complete the operation without injuring the nerve the closed technique should be abandoned in favour of the open posterior approach.
HYPERSENSITIVITY TO PARA-AMINOSALICYLIC ACID
Authors: Griffiths H. E. D. , Watts C. 
Published: February 2018

1. Attention is drawn to the incidence of hypersensitivity to para-aminosalicylic acid in the course of antituberculous treatment. 2. The clinical features are described with particular reference to hepatic complications. 3. Three cases are presented to illustrate the salient features of the condition. 4. The importance of early detection of the reaction, the giving of test doses and the technique of desensitisation of the patient to para-aminosalicylic acid are discussed.
A DIRECT APPROACH TO TRIMALLEOLAR FRACTURES
Authors: Patrick James 
Published: February 2018

1. A direct approach to trimalleolar fractures is described. 2. It is considered that a direct view of the fractured joint surface is essential in operations on all trimalleolar fractures and that access must be planned accordingly. 3. Failure to get a perfectly congruous surface is likely to be followed by osteoarthritis.
TREATMENT AND PREVENTION OF CHRONIC HAEMORRHAGIC ARTHROPATHY AND CONTRACTURES IN HAEMOPHILIA
Authors: France W. G. , Wolf P. 
Published: February 2018

1. Orthopaedic treatment of joint deformities in thirteen patients with haemophilia is reviewed over a period of seven years. 2. Forms of treatment discussed include open operation, manipulation under general anaesthesia, continuous traction, splintage and physiotherapy. The amount of intravenous therapy required for each form of treatment is indicated. 3. In discussing prevention of joint deformity the histories of a further eighteen patients have been taken into account. It is concluded that initially painless haemarthroses provide the main threat to joint deformity in haemophilia. 4. The best preventive treatment is early immobilisation followed by prolonged splintage and physiotherapy; intravenous therapy with antihaemophilic factor plays a less important role here than in other forms of haemorrhage. 5. Evidence is presented that joint deformity in severe haemophilia can often be entirely avoided.
A CLINICAL SYNDROME ASSOCIATED WITH SEVERE LUMBO-SACRAL SUBLUXATION
Authors: Newman P. H. 
Published: February 2018

1. Thirty-four patients with severe lumbo-sacral subluxation have been studied. Twenty-nine of these came for advice between the ages of nine and nineteen, and of these, twenty-five developed symptoms and signs of a characteristic syndrome. 2. The details of the syndrome are described: the essential features are spinal stiffness, a lordotic gait, resistance to straight leg raising, and in some cases evidence of interference with cauda equina or nerve root. 3. The danger of attempted reduction by traction is stressed, as well as the difficulties to be encountered during posterior lumbo-sacral fusion. 4. The reasons for operating are given; the results of spinal fusion were satisfactory. 5. The traditional apprehension concerning the effect of severe subluxation on childbirth has probably been over-stressed. 6. The tendency to slip was almost completely arrested by spinal fusion.