bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrothermal fluid evolution in the ‘Botro ai Marmi’ quartz-monzonitic intrusion, Campiglia Marittima, Tuscany, Italy. Evidence from a fluid-inclusion investigation
Authors: Fulignati Paolo 
Published: May 2018

ABSTRACTThe quartz-monzonitic intrusion of ‘Botro ai Marmi’ in Tuscany, Italy, can be considered to be a typical example of an intrusion-centred magmatic hydrothermal system. The evolution of hydrothermal fluids in the ‘Botro ai Marmi’ intrusion was investigated using fluid-inclusion analyses to provide suitable physico-chemical constraints on the fluids involved in the late- to post-magmatic hydrothermal activity that affected the intrusion, providing inferences on their origin and variations of temperature and pressure with time.This work demonstrates that the earliest fluids circulating in the ‘Botro ai Marmi’ intrusion were high-temperature brines exsolved directly from the crystallizing magma. This fluid circulated in the intrusion under lithostatic conditions (P > 90 MPa, T > 540°C). A second evolutionary stage of the magmatic hydrothermal system is marked by the transition from lithostatic (>90 MPa) to hydrostatic dominated conditions (50 to 10 MPa). In this stage the fluids are also interpreted to be mainly orthomagmatic in origin but unmixed in a high-salinity brine and in a low-salinity vapour aqueous phase, at a temperature ranging from ~500 to 300°C. These fluids were responsible for the potassic alteration facies. At a later stage of hydrothermal evolution, abundant meteoric dominated fluids entered the system and are associated with propylitic alteration. This event marks the transition from a magmatic-hydrothermal system to a typical hydrothermal (‘geothermal’) system, which can be assumed to be similar to some extent to the nearby active high-enthalpy geothermal system of Larderello. Low-temperature and low-salinity meteoric water-dominated fluids characterize the latest stage of the ‘Botro ai Marmi’ hydrothermal system.
Feynmanite, a new sodium uranyl sulfate mineral from Red Canyon, San Juan County, Utah, USA
Authors: Kampf Anthony R. , Olds Travis A. , Plášil Jakub , Marty Joe , Perry Samuel N. 
Published: May 2018

AbstractThe new mineral feynmanite, Na(UO2)(SO4)(OH)·3.5H2O, was found in both the Blue Lizard and Markey mines, San Juan County, Utah, USA, where it occurs as a secondary phase on pyrite-rich asphaltum in association with chinleite-(Y), gypsum, goethite, natrojarosite, natrozippeite, plášilite, shumwayite (Blue Lizard) and wetherillite (Markey). The mineral is pale greenish yellow with a white streak and fluoresces bright greenish white under a 405 nm laser. Crystals are transparent with a vitreous lustre. It is brittle, with a Mohs hardness of ~2, irregular fracture and one perfect cleavage on {010}. The calculated density is 3.324 g cm–3. Crystals are thin needles or blades, flattened on {010} and elongate on [100], exhibiting the forms {010}, {001}, {101} and {10$\bar{1}$}, and are up to ~0.1 mm in length. Feynmanite is optically biaxial (–), with α = 1.534(2), β = 1.561(2) and γ = 1.571(2) (white light); 2Vmeas.= 62(2)°; no dispersion; and optical orientation:X=b,Y≈a,Z≈c. It is weakly pleochroic:X= colourless,Y= very pale green yellow andZ= pale green yellow (X&lt;Y&lt;Z). Electron microprobe analyses (WDS mode) provided (Na0.84Fe0.01)(U1.01O2)(S1.01O4)(OH)·3.5H2O. The five strongest powder X-ray diffraction lines are [dobsÅ(I)(hkl)]: 8.37(100)(010), 6.37(33)($\bar{1}$01,101), 5.07(27)($\bar{1}$11,111), 4.053(46)(004,021) and 3.578(34)(120). Feynmanite is monoclinic, has space groupP2/n,a= 6.927(3),b= 8.355(4),c= 16.210(7) Å, β = 90.543(4)°,V= 938.1(7) Å3andZ= 4. The structure of feynmanite (R1= 0.0371 for 1879Io&gt; 2σI) contains edge-sharing pairs of pentagonal bipyramids that are linked by sharing corners with SO4groups, yielding a [(UO2)2(SO4)2(OH)2]2–sheet based on the phosphuranylite anion topology. The sheet is topologically identical to those in deliensite, johannite and plášilite. The dehydration of feynmanite to plášilite results in interlayer collapse involving geometric reconfiguration of the sheets and the ordering of Na.
Reliability of a novel thermal imaging system for temperature assessment of healthy feet
Authors: Petrova N. L. , Whittam A. , MacDonald A. , Ainarkar S. , Donaldson A. N. , Bevans J. , Allen J. , Plassmann P. , Kluwe B. , Ring F. , Rogers L. , Simpson R. , Machin G. , Edmonds M. E. 
Published: May 2018

AbstractBackgroundThermal imaging is a useful modality for identifying preulcerative lesions (“hot spots”) in diabetic foot patients. Despite its recognised potential, at present, there is no readily available instrument for routine podiatric assessment of patients at risk. To address this need, a novel thermal imaging system was recently developed. This paper reports the reliability of this device for temperature assessment of healthy feet.MethodsPlantar skin foot temperatures were measured with the novel thermal imaging device (Diabetic Foot Ulcer Prevention System (DFUPS), constructed by Photometrix Imaging Ltd) and also with a hand‐held infrared spot thermometer (Thermofocus® 01500A3, Tecnimed, Italy) after 20 min of barefoot resting with legs supported and extended in 105 subjects (52 males and 53 females; age range 18 to 69 years) as part of a multicentre clinical trial. The temperature differences between the right and left foot at five regions of interest (ROIs), including 1st and 4th toes, 1st, 3rd and 5th metatarsal heads were calculated. The intra‐instrument agreement (three repeated measures) and the inter‐instrument agreement (hand‐held thermometer and thermal imaging device) were quantified using intra‐class correlation coefficients (ICCs) and the 95% confidence intervals (CI).ResultsBoth devices showed almost perfect agreement in replication by instrument. The intra‐instrument ICCs for the thermal imaging device at all five ROIs ranged from 0.95 to 0.97 and the intra‐instrument ICCs for the hand‐held‐thermometer ranged from 0.94 to 0.97. There was substantial to perfect inter‐instrument agreement between the hand‐held thermometer and the thermal imaging device and the ICCs at all five ROIs ranged between 0.94 and 0.97.ConclusionsThis study reports the performance of a novel thermal imaging device in the assessment of foot temperatures in healthy volunteers in comparison with a hand‐held infrared thermometer. The newly developed thermal imaging device showed very good agreement in repeated temperature assessments at defined ROIs as well as substantial to perfect agreement in temperature assessment with the hand‐held infrared thermometer. In addition to the reported non‐inferior performance in temperature assessment, the thermal imaging device holds the potential to provide an instantaneous thermal image of all sites of the feet (plantar, dorsal, lateral and medial views).Trial registrationDiabetic Foot Ulcer Prevention System NCT02317835, registered December 10, 2014
Social media posts and online search behaviour as early-warning system for MRSA outbreaks
Authors: van de Belt Tom H. , van Stockum Pieter T. , Engelen Lucien J. L. P. G. , Lancee Jules , Schrijver Remco , Rodríguez-Baño Jesús , Tacconelli Evelina , Saris Katja , van Gelder Marleen M. H. J. , Voss Andreas 
Published: May 2018

Abstract
Background
Despite many preventive measures, outbreaks with multi-drug resistant micro-organisms (MDROs) still occur. Moreover, current alert systems from healthcare organizations have shortcomings due to delayed or incomplete notifications, which may amplify the spread of MDROs by introducing infected patients into a new healthcare setting and institutions. Additional sources of information about upcoming and current outbreaks, may help to prevent further spread of MDROs.
The study objective was to evaluate whether methicillin-resistant Staphylococcus aureus (MRSA) outbreaks could be detected via social media posts or online search behaviour; if so, this might allow earlier detection than the official notifications by healthcare organizations.

Methods
We conducted an exploratory study in which we compared information about MRSA outbreaks in the Netherlands derived from two online sources, Coosto for Social Media, and Google Trends for search behaviour, to the mandatory Dutch outbreak notification system (SO-ZI/AMR). The latter provides information on MDRO outbreaks including the date of the outbreak, micro-organism involved, the region/location, and the type of health care organization.

Results
During the research period of 15 months (455 days), 49 notifications of outbreaks were recorded in SO-ZI/AMR. For Coosto, the number of unique potential outbreaks was 37 and for Google Trends 24. The use of social media and online search behaviour missed many of the hospital outbreaks that were reported to SO-ZI/AMR, but detected additional outbreaks in long-term care facilities.

Conclusions
Despite several limitations, using information from social media and online search behaviour allows rapid identification of potential MRSA outbreaks, especially in healthcare settings with a low notification compliance. When combined in an automated system with real-time updates, this approach might increase early discovery and subsequent implementation of preventive measures.
The Tigecycline Evaluation and Surveillance Trial; assessment of the activity of tigecycline and other selected antibiotics against Gram-positive and Gram-negative pathogens from France collected between 2004 and 2016
Authors: Decousser Jean-Winoc , Woerther Paul-Louis , Soussy Claude-James , Fines-Guyon Marguerite , Dowzicky Michael J. 
Published: May 2018

Abstract
Background
A high level of antibiotic consumption in France means antimicrobial resistance requires rigorous monitoring. The Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) is a global surveillance study that monitors the in vitro activities of tigecycline and a panel of marketed antimicrobials against clinically important Gram-positive and Gram-negative isolates.

Methods
Annually clinically relevant strains were prospectively included in the survey through a national network of hospital-based laboratories. MICs were determined locally by broth microdilution using CLSI guidelines. Antimicrobial susceptibility was assessed using European Committee on Antimicrobial Susceptibility Testing breakpoints.

Results
Thirty-three centres in France collected 26,486 isolates between 2004 and 2016. Enterococcus species were highly susceptible (≥94.4%) to linezolid, tigecycline and vancomycin. Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), were susceptible (≥99.9%) to tigecycline, vancomycin and linezolid. Between 2004 and 2016, 27.7% of S. aureus isolates were MRSA, decreasing from 28.0% in 2013 to 23.5% in 2016. Susceptibility of Streptococcus pneumoniae isolates was 100% to vancomycin, and > 99.0% to levofloxacin, linezolid and meropenem; 3.0% were penicillin-resistant S. pneumoniae (100% susceptibility to vancomycin and linezolid). Escherichia coli isolates were highly susceptible (> 98.0%) to meropenem, tigecycline and amikacin. The rate of extended-spectrum β-lactamase (ESBL) positive E. coli increased from 2004 (3.0%), but was stable from 2012 (23.1%) to 2016 (19.8%). Susceptibility of Klebsiella pneumoniae isolates was 99.4% to meropenem and 96.5% to amikacin. The proportion of ESBL-positive K. pneumoniae isolates increased from 2004 (7.5%) to 2012 (33.3%) and was highest in 2016 (43.6%). A. baumannii was susceptible to meropenem (81.0%) and amikacin (74.9%); none of the 6.2% of isolates identified as multidrug-resistant (MDR) was susceptible to any agents with breakpoints. P. aeruginosa isolates were most susceptible to amikacin (88.5%), and MDR rates were 13.6% in 2013 to 4.0% in 2016; susceptibility of MDR isolates was no higher than 31.4% to amikacin.

Conclusions
Rates of MRSA decreased slowly, while rates of ESBL-positive E. coli and K. pneumoniae increased from 2004 to 2016. Susceptibility of Gram-positive isolates to vancomycin, tigecycline, meropenem and linezolid was well conserved, as was susceptibility of Gram-negative isolates to tigecycline and meropenem. The spread of MDR non-fermentative isolates must be carefully monitored.
Fabrication and optimization of Nanodiamonds-composited poly(ε-caprolactone) fibrous matrices for potential regeneration of hard tissues
Authors: Ahn Guk Young , Ryu Tae-Kyung , Choi Yu Ri , Park Ju Ri , Lee Min Jeong , Choi Sung-Wook 
Published: May 2018

Abstract

Background
Electrospun fibrous matrices are of great importance for tissue engineering and drug delivery device. However, relatively low mechanical strength of the fibrous matrix is one of the major disadvantages. NDs with a positive charge were selected to enhance the mechanical property of a composited fibrous matrix by inducing the intermolecular interaction between NDs and polymer chain. We prepared ND-composited poly (ε-caprolactone) (PCL) fibrous matrices by electrospinning and evaluated their performance in terms of mechanical strength and cell behaviors.

Methods
A predetermined amounts of NDs (0.5, 1, 2 and 3 wt%) were added into PCL solution in a mixture of chloroform and 2,2,2-trifluoroethanol (8:2). ND-composited PCL (ND/PCL) fibrous matrices were prepared by electrospinning method. The tensile properties of the ND/PCL fibrous matrices were analyzed by using a universal testing machine. Mouse calvaria-derived preosteoblast (MC3T3-E1) was used for cell proliferation, alkaline phosphatase (ALP) assay, and Alizarin Red S staining.

Results
The diameters of the fibrous matrices were adjusted to approximately 1.8 μm by changing process variables. The intermolecular interaction between NDs and PCL polymers resulted in the increased tensile strength and the favorable interfacial adhesion in the ND/PCL fibrous matrices. The ND/PCL fibrous matrix with 1 wt% of ND had the highest tensile strength among the samples and also improved proliferation and differentiation of MC3T3-E1 cells.

Conclusions
Compared to the other samples, the ND/PCL fibrous matrix with 1 wt% of ND concentration exhibited superior performances for MC3T3 cells. The ND/PCL fibrous matrix can be potentially used for bone and dental tissue engineering.
Alcohol use disorders in people with intellectual disability
Authors: Williams Fionnuala , Kouimtsidis Christos , Baldacchino Alexander 
Published: May 2018

SUMMARYThis article initially highlights that although the prevalence of alcohol use disorders in people with intellectual disability (PWID) appears to be low, it is a significant issue. This group can be more vulnerable to the adverse effects of alcohol and it is likely that many PWID who have alcohol use disorders are not being identified. We go on to review the limited existing literature on treatment for PWID who have alcohol use disorders and the challenges in meeting the needs of this patient group. We explore how assessment and treatment of alcohol use disorders in this population can be and needs to be tailored to the needs of PWID on an individual basis. There is also discussion about the use of incapacity legislation to treat this group.LEARNING OBJECTIVES•Be aware that alcohol use disorders can be especially problematic for PWID, that such disorders can often go undetected and that adapted screening techniques may be needed to identify such problems•Understand the difficulties that this population has in accessing addiction services and that successful management of PWID who misuse alcohol is usually dependent on appropriate joint working between intellectual disability and addiction services•Be aware that PWID are not a homogeneous group, rather they vary widely in their abilities, necessitating interventions tailored to the individual, and that the use of compulsory measures to manage PWID who lack capacity regarding to their alcohol use should be done with cautionDECLARATION OF INTERESTNone.
Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer
Authors: Wang Zhaoming , Wilson Carmen L. , Easton John , Thrasher Andrew , Mulder Heather , Liu Qi , Hedges Dale J. , Wang Shuoguo , Rusch Michael C. , Edmonson Michael N. , Levy Shawn , Lanctot Jennifer Q. , Caron Eric , Shelton Kyla , Currie Kelsey , Lear Matthew , Patel Aman , Rosencrance Celeste , Shao Ying , Vadodaria Bhavin , Yergeau Donald , Sapkota Yadav , Brooke Russell J. , Moon Wonjong , Rampersaud Evadnie , Ma Xiaotu , Chang Ti-Cheng , Rice Stephen V. , Pepper Cynthia , Zhou Xin , Chen Xiang , Chen Wenan , Jones Angela , Boone Braden , Ehrhardt Matthew J. , Krasin Matthew J. , Howell Rebecca M. , Phillips Nicholas S. , Lewis Courtney , Srivastava Deokumar , Pui Ching-Hon , Kesserwan Chimene A. , Wu Gang , Nichols Kim E. , Downing James R. , Hudson Melissa M. , Yasui Yutaka , Robison Leslie L. , Zhang Jinghui 
Published: May 2018

Purpose Childhood cancer survivors are at increased risk of subsequent neoplasms (SNs), but the germline genetic contribution is largely unknown. We assessed the contribution of pathogenic/likely pathogenic (P/LP) mutations in cancer predisposition genes to their SN risk. Patients and Methods Whole-genome sequencing (30-fold) was performed on samples from childhood cancer survivors who were ≥ 5 years since initial cancer diagnosis and participants in the St Jude Lifetime Cohort Study, a retrospective hospital-based study with prospective clinical follow-up. Germline mutations in 60 genes known to be associated with autosomal dominant cancer predisposition syndromes with moderate to high penetrance were classified by their pathogenicity according to the American College of Medical Genetics and Genomics guidelines. Relative rates (RRs) and 95% CIs of SN occurrence by mutation status were estimated using multivariable piecewise exponential regression stratified by radiation exposure. Results Participants were 3,006 survivors (53% male; median age, 35.8 years [range, 7.1 to 69.8 years]; 56% received radiotherapy), 1,120 SNs were diagnosed among 439 survivors (14.6%), and 175 P/LP mutations were identified in 5.8% (95% CI, 5.0% to 6.7%) of survivors. Mutations were associated with significantly increased rates of breast cancer (RR, 13.9; 95% CI, 6.0 to 32.2) and sarcoma (RR, 10.6; 95% CI, 4.3 to 26.3) among irradiated survivors and with increased rates of developing any SN (RR, 4.7; 95% CI, 2.4 to 9.3), breast cancer (RR, 7.7; 95% CI, 2.4 to 24.4), nonmelanoma skin cancer (RR, 11.0; 95% CI, 2.9 to 41.4), and two or more histologically distinct SNs (RR, 18.6; 95% CI, 3.5 to 99.3) among nonirradiated survivors. Conclusion The findings support referral of all survivors for genetic counseling for potential clinical genetic testing, which should be prioritized for nonirradiated survivors with any SN and for those with breast cancer or sarcoma in the field of prior irradiation.
Automated Assessment of Existing Patient’s Revised Cardiac Risk Index Using Algorithmic Software
Authors: Hofer Ira S. , Cheng Drew , Grogan Tristan , Fujimoto Yohei , Yamada Takashige , Beck Lauren , Cannesson Maxime , Mahajan Aman 
Published: May 2018

BACKGROUND:
Previous work in the field of medical informatics has shown that rules-based algorithms can be created to identify patients with various medical conditions; however, these techniques have not been compared to actual clinician notes nor has the ability to predict complications been tested. We hypothesize that a rules-based algorithm can successfully identify patients with the diseases in the Revised Cardiac Risk Index (RCRI).

METHODS:
Patients undergoing surgery at the University of California, Los Angeles Health System between April 1, 2013 and July 1, 2016 and who had at least 2 previous office visits were included. For each disease in the RCRI except renal failure—congestive heart failure, ischemic heart disease, cerebrovascular disease, and diabetes mellitus—diagnosis algorithms were created based on diagnostic and standard clinical treatment criteria. For each disease state, the prevalence of the disease as determined by the algorithm, International Classification of Disease (ICD) code, and anesthesiologist’s preoperative note were determined. Additionally, 400 American Society of Anesthesiologists classes III and IV cases were randomly chosen for manual review by an anesthesiologist. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve were determined using the manual review as a gold standard. Last, the ability of the RCRI as calculated by each of the methods to predict in-hospital mortality was determined, and the time necessary to run the algorithms was calculated.

RESULTS:
A total of 64,151 patients met inclusion criteria for the study. In general, the incidence of definite or likely disease determined by the algorithms was higher than that detected by the anesthesiologist. Additionally, in all disease states, the prevalence of disease was always lowest for the ICD codes, followed by the preoperative note, followed by the algorithms. In the subset of patients for whom the records were manually reviewed, the algorithms were generally the most sensitive and the ICD codes the most specific. When computing the modified RCRI using each of the methods, the modified RCRI from the algorithms predicted in-hospital mortality with an area under the receiver operating characteristic curve of 0.70 (0.67–0.73), which compared to 0.70 (0.67–0.72) for ICD codes and 0.64 (0.61–0.67) for the preoperative note. On average, the algorithms took 12.64 ± 1.20 minutes to run on 1.4 million patients.

CONCLUSIONS:
Rules-based algorithms for disease in the RCRI can be created that perform with a similar discriminative ability as compared to physician notes and ICD codes but with significantly increased economies of scale.