bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinspired Metal‐Free Formal Decarbonylation of α‐Branched Aliphatic Aldehydes at Ambient Temperature
Authors: Richter Sven C. , Oestreich Martin 
Published: May 2019

AbstractA sequence of a Baeyer–Villiger oxidation and a Lewis acid‐promoted reduction of the resulting formate with Et3SiH enabled the metal‐free formal decarbonylation of tertiary and secondary aliphatic aldehydes. The new methodology mimics the biosynthetic decarbonylation pathway through oxidative C−C bond cleavage rather than the C(O)−H bond activation known from conventional Tsuji–Wilkinson‐type reactions. The substrate scope is complementary to existing transition‐metal‐catalyzed protocols.
The Effect of Thermal Treatment on the Hydrogen‐Storage Properties of PIM‐1
Authors: Ramimoghadam Donya , Boyd Sue E. , Brown Christopher L. , Mac A. Gray Evan , Webb C. J. 
Published: May 2019

AbstractThere has been recent interest in polymers of intrinsic microporosity (PIMs) for solid‐state hydrogen‐storage materials; however, the gas‐sorption properties and conditions for hydrogen uptake are relatively unexplored. PIM‐1 has been synthesised using the condensation reaction between 3,3,3,3‐tetramethyl‐1,1‐spirobisindane‐5,5,6,6‐tetraol and 2,3,5,6‐tetrafluorophthalonitrile as precursors. The synthesised PIM‐1 was annealed at different temperatures for varying times and then characterised for hydrogen uptake at both ambient and cryogenic temperatures. The excess hydrogen PCT isotherms have been measured to high pressure (320 bar) for the first time and the effect of different annealing conditions on the hydrogen capacity is reported.
Shared Genetic Risk Factors Across Carbamazepine‐Induced Hypersensitivity Reactions
Authors: Nicoletti Paola , Barrett Sarah , McEvoy Laurence , Daly Ann K. , Aithal Guruprasad , Lucena M. Isabel , Andrade Raul J. , Wadelius Mia , Hallberg Pär , Stephens Camilla , Bjornsson Einar S. , Friedmann Peter , Kainu Kati , Laitinen Tarja , Marson Anthony , Molokhia Mariam , Phillips Elizabeth , Pichler Werner , Romano Antonino , Shear Neil , Sills Graeme , Tanno Luciana K. , Swale Ashley , Floratos Aris , Shen Yufeng , Nelson Matthew R. , Watkins Paul B. , Daly Mark J. , Morris Andrew P. , Alfirevic Ana , Pirmohamed Munir 
Published: May 2019

Carbamazepine (CBZ) causes life‐threating T‐cell‐mediated hypersensitivity reactions, including serious cutaneous adverse reactions (SCARs) and drug‐induced liver injury (CBZ‐DILI). In order to evaluate shared or phenotype‐specific genetic predisposing factors for CBZ hypersensitivity reactions, we performed a meta‐analysis of two genomewide association studies (GWAS) on a total of 43 well‐phenotyped Northern and Southern European CBZ‐SCAR cases and 10,701 population controls and a GWAS on 12 CBZ‐DILI cases and 8,438 ethnically matched population controls. HLA‐A*31:01 was identified as the strongest genetic predisposing factor for both CBZ‐SCAR (odds ratio (OR) = 8.0; 95% CI 4.10–15.80; P = 1.2 × 10−9) and CBZ‐DILI (OR = 7.3; 95% CI 2.47–23.67; P = 0.0004) in European populations. The association with HLA‐A*31:01 in patients with SCAR was mainly driven by hypersensitivity syndrome (OR = 12.9; P = 2.1 × 10−9) rather than by Stevens‐Johnson syndrome/toxic epidermal necrolysis cases, which showed an association with HLA‐B*57:01. We also identified a novel risk locus mapping to ALK only for CBZ‐SCAR cases, which needs replication in additional cohorts and functional evaluation.
Sustainable development and human resource management: A science mapping approach
Authors: Santana Monica , Lopez‐Cabrales Alvaro 
Published: May 2019

AbstractThis manuscript presents a systematic review of “sustainable human resource management” (HRM), highlighting its major themes and the evolution and tendencies observed in this field. It contributes to the development of this relatively new topic, offering a critical evaluation and identifying the highest impact research strands. The Web of Science database returned 111 documents spanning the period 1997–2018, and a conceptual science mapping analysis based on co‐word bibliographic networks was developed, using SciMAT as an analytical tool. The motor themes (well developed and important for the structure of the discipline) in the field of sustainable HRM are environmental management, socially responsible HRM, and turnover. Employee engagement is a specialised theme (well developed but less important for the structure of the research field), human resource practices is a basic or transversal theme (important for the discipline but not developed), and sustainable leadership and environmental performance are emerging themes (both weakly developed and marginal to the field).
Non‐Solvent Fractionation of Lignin Enhances Carbon Fiber Performance
Authors: Li Qiang , Li Mengjie , Lin Hao‐Sheng , Hu Cheng , Truong Phuc , Zhang Tan , Sue Hung‐Jue , Pu Yunqiao , Ragauskas Arthur J. , Yuan Joshua S. 
Published: May 2019

AbstractEven though lignin carbon fiber has been sought after for several decades, the poor mechanical performance remains to be a major barrier for commercial applications. The low mechanical performance is attributed to the heterogeneity of lignin polymer. Recent advances in fractionation technologies showed the great potential to reduce lignin heterogeneity, but current fractionation methods often depend on costly chemicals and materials such as enzymes, organic solvents, membranes, and dialysis tubes. Here, a new non‐solvent strategy was developed to fractionate lignin by autohydrolysis. By using only water, lignin was efficiently fractionated into water‐soluble and ‐insoluble fractions. The latter fraction had increased molecular weight and uniformity and resulted in more β‐O‐4 interunitary linkages as analyzed by size‐exclusion chromatography and 2D heteronuclear single quantum coherence NMR spectroscopy, respectively. In particular, the water‐insoluble fraction significantly enhanced the mechanical performances of the resultant carbon fibers. Mechanistic study by differential scanning calorimetry (DSC) revealed that the miscibility of lignin with guest polyacrylonitrile molecules was improved with the reduced lignin heterogeneity. Crystallite analyses by XRD and Raman spectroscopy revealed that the crystallite size and content of the pre‐graphitic turbostratic carbon structure were increased. The fundamental understanding revealed how lignin fractionation could modify lignin chemical features to enhance the mechanical performance of resultant carbon fibers. The autohydrolysis fractionation thus represents a green, economic, and efficient methodology to process lignin waste and boost lignin carbon fiber quality, which could open new horizons for lignin valorization.
Preferential sampling for presence/absence data and for fusion of presence/absence data with presence‐only data
Authors: Gelfand Alan E. , Shirota Shinichiro 
Published: May 2019

AbstractPresence/absence data and presence‐only data are the two customary sources for learning about species distributions over a region. We present an ambitious agenda with regard to the analysis of such data. We illuminate the fundamental modeling differences between the two types of data. Most simply, locations are considered to be fixed under presence/absence data; locations are random under presence‐only data. The definition of “probability of presence” is incompatible between the two. We are not comfortable with modeling strategies in the literature that ignore this incompatibility and that assume that presence/absence modeling can be induced from presence‐only specifications and, therefore, that fusion of presence‐only and presence/absence data sources is routine. While, in some cases, data collection may not support this, we propose that, since, in nature, presence/absence is seen at the point locations, presence/absence data should be modeled at point level. If so, we need to specify two surfaces. The first provides the probability of presence at any location in the region. The second provides a realization from this surface in the form of a binary map yielding the results of Bernoulli trials across all locations; this surface is only partially observed. On the other hand, presence‐only data should be modeled as a (partially observed) point pattern, arising from a random number of individuals seen at random locations, driven by specification of an intensity function. There is no notion of Bernoulli trials; events are associated with areas. We further suggest that, with just presence/absence data, preferential sampling of locations may arise. Accounting for this, using a shared process perspective, can improve our estimated presence/absence surface as well as prediction of presence. We further propose that preferential sampling can enable a probabilistically coherent fusion of the two data types. We illustrate with two real data sets, one presence/absence, one presence‐only, for invasive species presence in New England in the United States. We demonstrate that potential bias in sampling locations can affect inference with regard to presence/absence and show that inference can be improved with preferential sampling ideas. We also provide a probabilistically coherent fusion of the two data sets again with the goal of improving inference for presence/absence. The importance of our work is to encourage more careful modeling when studying species distributions. Ignoring incompatibility between data types and adopting nongenerative modeling specifications results in invalid inference; the quantitative ecological community should benefit from this recognition.
The influence of yeast level and fermentation temperature on Ochratoxin A decrement during bread making
Authors: Mozaffary Payman , Milani Jafar M. , Heshmati Ali 
Published: May 2019

AbstractOchratoxin A (OTA) occurrence in cereals is a permanent challenge in human health. In recent years, some studies have focused on the role of yeasts as adsorbing tools to eliminate OTA. The aim of the current research was to study the effects of different variables including Saccharomyces cerevisiae amount and the fermentation temperature on the reduction of OTA during bread baking. For this purpose, the OTA was spiked to the flour and then the bread was prepared. OTA levels in flour, dough, and bread were measured by the high‐performance liquid chromatography with fluorescence detector (HPLC‐FD). The results revealed that yeast level and fermentation temperature had a significant effect on OTA reduction. The increase of the amount of S. cerevisiae from 1% to 2% w/w and the fermentation temperature from 25ºC to 30ºC resulted in the increment of OTA reduction from 31.17% to 59.41%. During baking, OTA reduction was 19.21%. In general, the utilization of 2% w/w S. cerevisiae and the fermentation temperature of 35 ºC could reduce considerable amount of OTA in the wheat bread.
Thyroid disruption properties of three indoor dust chemicals tested in Silurana tropicalis tadpoles
Authors: Carlsson Gunnar , Pohl Johannes , Athanassiadis Ioannis , Norrgren Leif , Weiss Jana 
Published: May 2019

AbstractIndoor dust contains a multitude of industrial chemicals, and ingestion of dust is considered an important exposure route to organic contaminants. Some of these contaminants have been shown to interfere with the thyroid system, which may result in significant consequences on public health. The amphibian metamorphosis is a thyroid hormone‐dependent process, which can be used as an in vivo model for studies on thyroid hormone‐disrupting potency. Three contaminants of indoor dust were tested on metamorphosing Silurana (Xenopus) tropicalis tadpoles. The tested chemicals were Tris (1,3‐dichloroisopropyl) phosphate (TDCiPP), tetrabromobisphenol‐A (TBBPA) and propylparaben (PrP). Measurements reflecting general growth, development progress and thyroid epithelial cell height were performed on the exposed tadpoles as well as chemical analyses of the exposure water. It was shown that TDCiPP acts as a thyroid hormone‐disrupting chemical in metamorphosing tadpoles by causing increased epithelial cell height in thyroid glands after exposure to a nominal concentration of 0.010 mg/L and in higher concentrations. TBBPA caused reductions in general growth of tadpoles at the nominal concentration 0.125 mg/L, and PrP caused acute toxicity at the nominal concentration 12.5 mg/L. However, no evident indications of specific thyroid‐disrupting effects caused by TBBPA or PrP were observed.
CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages
Authors: Okada Hiroyuki , Kajiya Hiroshi , Omata Yasunori , Matsumoto Takumi , Sato Yuiko , Kobayashi Tami , Nakamura Satoshi , Kaneko Yosuke , Nakamura Shinya , Koyama Takuma , Sudo Shunichi , Shin Masashi , Okamoto Fujio , Watanabe Hisato , Tachibana Naohiro , Hirose Jun , Saito Taku , Takai Toshiyuki , Matsumoto Morio , Nakamura Masaya , Okabe Koji , Miyamoto Takeshi , Tanaka Sakae 
Published: May 2019

ABSTRACT
CTLA4-Ig (cytotoxic T-lymphocyte antigen 4-immunoglobulin; Abatacept) is a biologic drug for rheumatoid arthritis. CTLA4 binds to the CD80/86 complex of antigen-presenting cells and blocks the activation of T cells. Although previous reports showed that CTLA4-Ig directly inhibited osteoclast differentiation, the whole inhibitory mechanism of CTLA4-Ig for osteoclast differentiation is unclear. Bone marrow macrophages (BMMs) from WT mice were cultured with M-CSF and RANKL with or without the recombinant mouse chimera CTLA4-Ig. Intracellular calcium oscillations of BMMs with RANKL were detected by staining with calcium indicator fura-2 immediately after administration of CTLA4-Ig or after one day of treatment. Calcium oscillations were analyzed using Fc receptor gamma- (FcRγ-) deficient BMMs. CTLA4-Ig inhibited osteoclast differentiation and reduced the expression of the nuclear factor of activated T cells NFATc1 in BMMs in vitro. Calcium oscillations in BMMs were suppressed by CTLA4-Ig both immediately after administration and after one day of treatment. CTLA4-Ig did not affect osteoclastogenesis and did not cause remarkable changes in calcium oscillations in FcRγ-deficient BMMs. Finally, to analyze the effect of CTLA4-Ig in vivo, we used an LPS-induced osteolysis model. CTLA4-Ig suppressed LPS-induced bone resorption in WT mice, not in FcRγ-deficient mice. In conclusion, CTLA4-Ig inhibits intracellular calcium oscillations depending on FcRγ and downregulates NFATc1 expression in BMMs. © 2019 American Society for Bone and Mineral Research.
Association of IL1RL1 rs3771180 and TSLP rs1837253 variants with asthma in the Guangxi Zhuang population in China
Authors: Sun Yan , Wei Xuan , Deng Jingmin , Zhang Jianquan , He Zhiyi , Yang Meiling , Liang Siqiao , Chen Zhangrong , Qin Huajiao 
Published: May 2019

AbstractObjectiveIL‐1 receptor‐like 1 (IL1RL1) and thymic stromal lymphopoietin (TSLP) play important roles in asthma in various ways. IL1RL1 rs3771180 and TSLP rs1837253 single nucleotide polymorphisms (SNPs) are associated with asthma in some European nationals but not in Zhuang people. Accordingly, this study aimed to determine the associations of IL1RL1 rs3771180 and TSLP rs1837253 with asthma in Zhuang people.MethodsWe performed a case‐control study to observe the association between the two polymorphisms and asthma in a Guangxi Zhuang cohort consisting of 123 asthmatic patients and 100 healthy controls. These individuals were recruited from the Department of Respiration of the First Affiliated Hospital of Guangxi Medical University. Multiplex PCR assay was used to identify the genotype of rs3771180 and rs1837253. Data were analyzed with SPSS 22.0 and SHEsis.Resultsrs1837253 showed significant differences between asthmatic and control groups in allele comparison (OR = 2.15; 95% CI = 1.27‐3.63; P = 0.004), as well as in the homozygote (OR = 4.83; 95% CI = 1.47‐16.47; P = 0.012), heterozygote (OR = 2.69; 95% CI = 1.20‐6.00; P = 0.016), and dominant (OR = 3.01; 95% CI = 1.39‐6.52; P = 0.005) genetic models. However, the genotype frequencies of rs3771180 did not obviously differ.Conclusionrs1837253 is associated with asthma susceptibility and may increase the risk of asthma in Zhuang people in Guangxi.
Family processes among Latino Early Head Start families: Understanding the role of caregiver acculturation
Authors: Hurwich‐Reiss Eliana , Watamura Sarah E. 
Published: May 2019

AbstractThe Family Stress Model (FSM) provides a framework for how economic pressure can impact family processes and outcomes, including parent's mental health, parenting, and child problem behaviors. Although the FSM has been widely replicated, samples disproportionately impacted by poverty, including early childhood samples and in particular Latino families with young children, have been largely excluded from FSM research. Therefore, among a sample of Latino Early Head Start children (N = 127), the current study evaluated a modified FSM to understand the direct and indirect pathways among economic pressure, parental depression, parenting self‐efficacy, the parent–child relationship, child problem behaviors, and parental acculturation. Results showed that the majority of the direct FSM pathways were well‐replicated among Latino caregivers of young children. Further analyses illuminated how some pathways were replicated among more but not among less‐acculturated Latino parents. Implications for future FSM research with Latino families as well as for parent‐focused interventions are discussed.
Retracted: CCR5 silencing reduces inflammatory response, inhibits viability, and promotes apoptosis of synovial cells in rat models of rheumatoid arthritis through the MAPK signaling pathway
Authors: Lan You‐Yu , Wang You‐Qiang , Liu Yi 
Published: May 2019

AbstractRheumatoid arthritis (RA) is a chronic inflammatory disorder that can, in severe cases, lead to disability. CC chemokine receptor (CCR), an integral membrane protein, has been suggested to play a key role in the RA developmentThis study is to explore the role of CCR5 silencing in inflammatory response, viability, and apoptosis of synovial cells in RA rats by inactivating the mitogen‐activated protein kinase (MAPK) signaling pathway. Microarray analysis was conducted to screen out differentially expressed genes from RA‐related chips. The rat model was established by injection of siRNA‐CCR5 and PD98059 (inhibitor of mitogen‐activated protein kinase kinase 1) to evaluate the role of CCR5 silencing in RA, with the involvement of inflammatory response, synovial cell viability, apoptosis, and cycle. CCR5 was predicted to participate in RA by regulating the MARK pathway. In animal experiments, reduction was identified in arthritis index (AI), CCR5 positive expression rate, levels of tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), matrix metalloproteinase (MMP)‐1, and MMP‐3 in serum of RA rats after CCR5 siRNA and PD98059 injections. RA rats treated with CCR5 siRNA, and PD98059 presented with inhibition in cell viability, promotion of apoptosis, increase in cell proportion in G0/G1 phase, and shortened the S phase. In addition, the treatment of CCR5 siRNA, and PD98059 resulted in downregulated JNK1, ERK1, p38, Cyclin D1, Cyclin E1, Cyclin B1, and Bcl‐2 and upregulated Bax and Cas3. These findings reveal that CCR5 silencing suppresses inflammatory response, inhibits viability, and promotes apoptosis of synovial cells in RA rats by inhibiting MAPK pathway. Therefore, CCR5 silencing may provide a novel therapeutic target for RA.
Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer's disease by upregulating IGF‐2
Authors: Wu Kaimin , Zhang Ruiyi , Lu Yanhui , Wen Lulu , Li Yanfei , Duan Ranran , Yao Yaobing , Jia Yanjie 
Published: May 2019

AbstractMesenchymal stem cells (MSCs) transplantation has emerged as a potential therapeutic approach for Alzheimer's disease (AD). However, the poor proliferation capacity and low survival rate of engrafted MSCs in the hostile microenvironment of AD limit their therapeutic efficiency. Lin28B is a conserved RNA‐binding protein associated with cell self‐renewal and survival. The purpose of the present study was to explore whether lin28B might influence the functions of implanted MSCs and strengthen their neuroprotective potential in AD. A gain‐of‐function assay was used to upregulate lin28B expression in MSCs by lentiviral transfection. Our in vitro results indicated that lin28B promoted MSCs proliferation and migration, and protected MSCs against Aβ1–42‐induced cell death by upregulating insulin‐like growth factor‐2 (IGF‐2). Blockage of IGF‐2 partially abrogated the above effects of lin28B. After intracerebroventricular injection into amyloid precursor protein/presenilin 1 mice, implanted MSCs were monitored using bioluminescence imaging. We observed that administration of MSCs transfected with lin28B significantly stimulated their proliferation and prolonged cell retention after delivery. Moreover, administration of the transfected MSCs markedly mitigated cognitive deficits, promoted amyloid plaque clearance, decreased the activation of microglia, and reduced neuronal cell death. The data above confirmed our hypothesis that lin28B is a crucial modulator determining the fate of transplanted MSCs by regulating IGF‐2‐associated pathways and thereby enhancing their protective effects against AD.
LncRNAs associated with multiple sclerosis expressed in the Th1 cell lineage
Authors: Hosseini Aref , Teimuri Shohreh , Ehsani Marzieh , Rasa Seyed Mohammad Mahdi , Etemadifar Masoud , Nasr Esfahani Mohammad Hossein , Megraw Timothy L. , Ghaedi Kamran 
Published: May 2019

AbstractMultiple sclerosis (MS) is a type of inflammatory and demyelinating disorder of the central nervous system in which immune‐mediated inflammatory processes are elicited by secreted cytokines from T helper (Th)‐1 and Th17 cells. While some protein‐coding genes expressed in T cell types have established involvement in MS disease progression, little is understood about the roles of long noncoding RNAs (lncRNAs) within the disease landscape. LncRNAs, noncoding RNAs longer than 200 nucleotides, likely control gene expression and function of Th1 cells, and offer the potential to act as therapeutic and biomarker candidates for MS. We identified lncRNAs in Th1 cells linked to MS. Expression levels of candidate lncRNAs and genes were evaluated in 50 MS patients and 25 healthy controls using quantitative real‐time polymerase chain reaction, and their correlations were assessed. LncRNAs encoded by AC007278.2 and IFNG‐AS1‐001 showed significantly higher expression in relapsing Phase MS patients whereas IFNG‐AS1‐003 was elevated in patients in the remitting phase compared with relapsing patients. Collectively, these misregulated lncRNAs may provide valuable tools to understand the relationships between lncRNAs and MS, and possibly other related disorders.