bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Educational Digital Tool to Improve the Implementation of Switching to a Biosimilar (Rapid Switch Trainer): Tool Development and Validation Study
Authors: Marras Carlos , Labarga María , Ginard Daniel , Carrascosa Jose Manuel , Escudero-Contreras Alejandro , Collantes-Estevez Eduardo , de Mora Fernando , Robles Tamara , Romero Elisa , Martínez Rafael 
Published: December 2024

Abstract

Background
Switching to biosimilars is an effective and safe practice in treating inflammatory diseases; however, a nocebo effect may arise as a result of the way in which the switch is communicated to a given patient.

Objective
We aimed to design a gaming-based digital educational tool (including a discussion algorithm) to support the training of health care professionals in efficiently communicating the switch to biosimilars, minimizing the generation of a nocebo effect and thus serving as an implementation strategy for the recommended switch.

Methods
The tool was developed based on interviews and focus group discussions with key stakeholders, both patients and health care professionals. Messages likely to either generate trust or to trigger a nocebo effect were generated on the basis of the interviews and focus group discussions.

Results
A total 7 clinicians and 4 nurses specializing in rheumatology, gastroenterology, and dermatology, with balanced levels of responsibility and experience, as well as balance between geographic regions, participated in the structured direct interviews and provided a list of arguments they commonly used, or saw used, to justify the switching, and objections given by the patients they attended. Patients with immune-mediated inflammatory diseases who were taking biologic drugs with (n=4) and without (n=5) experience in switching attended the focus groups and interviews. Major topics of discussion were the reason for the change, the nature of biosimilars, and their quality, safety, efficacy, and cost. Based on these discussions, a list of objections and of potential arguments was produced. Patients and health care professionals rated the arguments for their potential to evoke trust or a nocebo effect. Two sets of arguments, related to savings and sustainability, showed discrepant ratings between patients and health care professionals. Objections and arguments were organized by categories and incorporated into the tool as algorithms. The educators then developed additional arguments (with inadequate answers) to complement the valid ones worked on in the focus groups. The tool was then developed as a collection of clinical situations or vignettes that appear randomly to the user, who then has to choose an argument to counteract the given objections. After each interaction, the tool provides feedback. The tool was further supported by accredited medical training on biosimilars and switching.

Conclusions
We have developed a digital training tool to improve communication on switching to biosimilars in the clinic and prevent a nocebo effect based on broad and in-depth experiences of patients and health care professionals. The validation of this implementation strategy is ongoing.
Performance Comparison of Junior Residents and ChatGPT in the Objective Structured Clinical Examination (OSCE) for Medical History Taking and Documentation of Medical Records: Development and Usability Study
Authors: Huang Ting-Yun , Hsieh Pei Hsing , Chang Yung-Chun 
Published: December 2024

Abstract

Background
This study explores the cutting-edge abilities of large language models (LLMs) such as ChatGPT in medical history taking and medical record documentation, with a focus on their practical effectiveness in clinical settings—an area vital for the progress of medical artificial intelligence.

Objective
Our aim was to assess the capability of ChatGPT versions 3.5 and 4.0 in performing medical history taking and medical record documentation in simulated clinical environments. The study compared the performance of nonmedical individuals using ChatGPT with that of junior medical residents.

Methods
A simulation involving standardized patients was designed to mimic authentic medical history–taking interactions. Five nonmedical participants used ChatGPT versions 3.5 and 4.0 to conduct medical histories and document medical records, mirroring the tasks performed by 5 junior residents in identical scenarios. A total of 10 diverse scenarios were examined.

Results
Evaluation of the medical documentation created by laypersons with ChatGPT assistance and those created by junior residents was conducted by 2 senior emergency physicians using audio recordings and the final medical records. The assessment used the Objective Structured Clinical Examination benchmarks in Taiwan as a reference. ChatGPT-4.0 exhibited substantial enhancements over its predecessor and met or exceeded the performance of human counterparts in terms of both checklist and global assessment scores. Although the overall quality of human consultations remained higher, ChatGPT-4.0’s proficiency in medical documentation was notably promising.

Conclusions
The performance of ChatGPT 4.0 was on par with that of human participants in Objective Structured Clinical Examination evaluations, signifying its potential in medical history and medical record documentation. Despite this, the superiority of human consultations in terms of quality was evident. The study underscores both the promise and the current limitations of LLMs in the realm of clinical practice.
Comparing the Accuracy of Two Generated Large Language Models in Identifying Health-Related Rumors or Misconceptions and the Applicability in Health Science Popularization: Proof-of-Concept Study
Authors: Luo Yuan , Miao Yiqun , Zhao Yuhan , Li Jiawei , Chen Yuling , Yue Yuexue , Wu Ying 
Published: December 2024

Abstract

Background
Health-related rumors and misconceptions are spreading at an alarming rate, fueled by the rapid development of the internet and the exponential growth of social media platforms. This phenomenon has become a pressing global concern, as the dissemination of false information can have severe consequences, including widespread panic, social instability, and even public health crises.

Objective
The aim of the study is to compare the accuracy of rumor identification and the effectiveness of health science popularization between 2 generated large language models in Chinese (GPT-4 by OpenAI and Enhanced Representation through Knowledge Integration Bot [ERNIE Bot] 4.0 by Baidu).

Methods
In total, 20 health rumors and misconceptions, along with 10 health truths, were randomly inputted into GPT-4 and ERNIE Bot 4.0. We prompted them to determine whether the statements were rumors or misconceptions and provide explanations for their judgment. Further, we asked them to generate a health science popularization essay. We evaluated the outcomes in terms of accuracy, effectiveness, readability, and applicability. Accuracy was assessed by the rate of correctly identifying health-related rumors, misconceptions, and truths. Effectiveness was determined by the accuracy of the generated explanation, which was assessed collaboratively by 2 research team members with a PhD in nursing. Readability was calculated by the readability formula of Chinese health education materials. Applicability was evaluated by the Chinese Suitability Assessment of Materials.

Results
GPT-4 and ERNIE Bot 4.0 correctly identified all health rumors and misconceptions (100% accuracy rate). For truths, the accuracy rate was 70% (7/10) and 100% (10/10), respectively. Both mostly provided widely recognized viewpoints without obvious errors. The average readability score for the health essays was 2.92 (SD 0.85) for GPT-4 and 3.02 (SD 0.84) for ERNIE Bot 4.0 (P=.65). For applicability, except for the content and cultural appropriateness category, significant differences were observed in the total score and scores in other dimensions between them (P<.05).

Conclusions
ERNIE Bot 4.0 demonstrated similar accuracy to GPT-4 in identifying Chinese rumors. Both provided widely accepted views, despite some inaccuracies. These insights enhance understanding and correct misunderstandings. For health essays, educators can learn from readable language styles of GLLMs. Finally, ERNIE Bot 4.0 aligns with Chinese expression habits, making it a good choice for a better Chinese reading experience.
Antibacterial Activity and Molecular Docking of Compounds from <i>Avicennia marina</i> Leaves Extracts: Obtained by Natural Deep Eutectic Solvents
Authors: Kartikaningsih Hartati , Djamaludin Heder , Audina Nanda , Fauziyah Jihan Nur 
Published: December 2024

This study aims to determine the effect of using natural deep eutectic solvent in extracting compounds from young and old leaves of Avicennia marina on the antibacterial activity through in vitro and in silico. The research method used was experimental with different molar ratios of solvent components: citric acid and glucose (1:1, 2:1, 3:1, 4:1 v/v). In vitro, the paper-disk method was employed to assess percent inhibition, and in silico, peptide deformylase (ID 6JFQ) was the target of the investigation. The best treatment results for testing the antibacterial activity of A. marina leaves extracts that were extracted using natural deep eutectic solvent against S. aureus and E. coli was citric acid and glucose (molar ratio 4:1). The inhibition zone by old leaves extracts was 27.47 and 37.73 mm, and by young leaves extracts were 28.69 and 30.99 mm. Then, phytochemical compound analysis was done using liquid chromatography-mass spectrometry, and six phytochemical compounds were obtained. The docking results showed that the diosmetin 7-O-β-D-glucuronide has the best binding affinity (−9.4 kcal/mol) towards the peptide deformylase. Purification must be done to obtain pure compounds from crude extracts of A. marina leaves.
Entre amor, vergonha e culpa: uma análise política das emoções no contexto familiar de homens trans
Authors: Monteiro Anne Alencar , McCallum Cecilia Anne 
Published: December 2024

Este artigo analisa os discursos emocionais e emocionados ligados às experiências de familiares de homens trans durante o processo de transição de gênero. A discussão trata dos resultados de uma pesquisa etnográfica que utilizou diferentes estratégias metodológicas em três cidades do nordeste brasileiro, sendo duas capitais e uma cidade do interior, entre 2020 e 2023. Inicialmente o artigo aborda os sentimentos, relatados pelos parentes dos homens trans, de vergonha e culpa associados a transgeneridade, frente às hierarquias de gênero e ao papel hegemônico que se espera que uma “boa mãe” performe. Em seguida, a análise explora como esses sentimentos “negativos” dão lugar ao amor, nas falas das nossas interlocutoras. A descrição sobre o amor emerge nos discursos familiares como justificativa para aceitar e apoiar a transição de gênero, tornando-se parte constitutiva das relações de parentesco. Além disso, o amor é utilizado como estratégia de mobilização política em um grupo ativista composto majoritariamente por mães de filhos e filhas LGBTQIAPN+. A análise dessas retóricas políticas da emoção demonstra que as concepções hegemônicas sobre a maternidade, ligadas ao amor e ao cuidado, abrem a possibilidade para que essas pessoas possam agir frente às normas de gênero e sexualidade. O artigo contribui, portanto, para compreender a maneira como as emoções são acionadas como elementos constitutivos dos meios e dos limites da agência individual e coletiva, conforme colocado por Saba Mahmood (2019), demonstrando a complexidade do potencial político das emoções frente às relações normativas de subordinação e poder.
Modernising Agrarian Societies: The Interwar Global East through the Lens of Polish and ILO Agrarian Experts
Authors: Stegmann Natali 
Published: December 2024

Abstract
This article analyses the ILO’s administrative practice on agricultural issues in the interwar period. On the surface, the ILO did not succeed in assuming a prominent position in the agricultural question. However, the article goes beyond this failure by focussing on the newly founded states of East Central Europe. It interprets the work of the tripartite actors and the experts from the region and works out how these actors shared a common conception of developed and underdeveloped countries with the Western internationalists and how they tried to overcome their weak position through statism and social engineering (e.g. land reforms).
Le premier plan décennal de l’Agenda 2063 : perspectives d’une décentralisation du cadre de transformation de l’Union Africaine
Authors: Bekale Ladislas Nze 
Published: December 2024

Abstract
Following the adoption of the ten-year plan for implementing Agenda 2063, it is necessary to draw lessons from its implementation. The strict supervision of the executive of the African Union demonstrates a mixed appropriation by the Member States and the RECs, which seem to act according to the will of the state actors while Agenda 2063 calls for an inclusive approach. Thus, a decentralization of the AU transformation framework is fundamentally linked to the ratification at the national level of certain legal instruments as well as the operationalization of representing local authorities in the governance of the African Union.
PIR sensor-based automatic solar-powered UVC LED sterilizer lamp
Authors: Mohamed Junaid K. A. , Sukhi Y. , Jeyashree Y. , Mohana Sundaram K. 
Published: December 2024

Abstract
A PIR sensor-based automatic solar-powered UVC LED sterilizer lamp is UV-based air disinfection system that kills the microorganisms, including COVID-19 virus, floating freely in the air of a room. This lamp is designed using embedded system for automatic control of UV lamps based on the human presence. This is carefully designed to ensure that the end user is protected. The automatic detection unit shuts OFF the UV in case if a human is detected. The product is PV powered but also has an option with line 220 V mains supply. The bank of UV LEDS is completely enclosed. The battery is charged using a solar panel that has a backup of 8 h. This study includes the design and implementation of PIR sensor-based automatic solar-powered UVC LED sterilizer lamp using the components such as PIR sensor, DC-DC converter, Arduino board, PV panel, battery, charging circuit, and UV LED array.
The Effect of Differentiated Instruction based on Multiple Intelligences toward Critical Thinking and Student Self-Efficacy
Authors: Bariyah Khairul , Sugiman Sugiman 
Published: December 2024

Mathematics learning is often teacher-centered, where teachers directly present material to students without considering students' learning needs and improving their critical thinking skills. The lack of students' self-efficacy as a motivational factor will affect the development of their critical thinking level. This study aims to determine the effectiveness of differentiated instruction based on multiple intelligences to improve student's critical thinking and self-efficacy. This research employed a quantitative approach and a quasi-experimental research design. This study focused on mathematics learning using the differentiated instruction approach in the vector topic for Year 10 students in one senior high school at Langsa, Aceh, Indonesiaand compared differentiated instruction and scientific approach. Based on the population, the experimental group implemented differentiated instruction, and the control group applied a scientific approach. The hypothesis was tested using MANOVA, Hotelling's T2 test, and independent sample t-test. The effect size of differentiated instruction was determined based on the Cohen d-effect size calculation. The results of this study indicate that differentiated instruction has a moderate effect on students' critical thinking but does not significantly affect their self-efficacy. Therefore, differentiated instruction can be considered as one of the effective approaches for enhancing students' critical thinking skills.
Relationship between ABO Blood Groups and Rh Factor with COVID-19 in Nineveh Governorate
Authors: Mustafa Rasha Jamal Al Deen 
Published: December 2024

ABO blood types and the Rh factor have recently been linked to an increased risk of developing the pandemic coronavirus disease 2019 (COVID-19) in individuals of different ethnic backgrounds. The conducted current study aimed to comprehend the relationship between this polymorphic apparatus and illness risk in Nineveh patients and healthy individuals. Recovery or death and two COVID-19 outcomes were also investigated. Many individuals including COVID-19 Nineveh patients had their ABO blood type and Rh factors determined. Thus, four groups (under therapy, rehabilitative, death, and healthy donors) were created from the research samples. The diagnosis kit RNA (PCR-Fluorescence Probing) was used to diagnose 2019 novel coronavirus (2019nCoV) for patients. The data was gathered from hospital records. The purpose of this study was to highlight significant data related to COVID-19 patients’ infection, symptoms and prognosis with respect to ABO blood type and Rh factor. Results of the current study included links between Rh factor and ABO blood types with increased infection potential, longer incubation times and fatal acute outcomes. Knowing that COVID-19 predisposing factors might help with patient survival, illness treatment and studying viral path physiology. A total of 2480 samples were ،distributed to control group and hospitalized patients with definite COVID-19 infection in isolation in the hospital in Mosul City for the period between 2nd December 2021 and 5th March 2022. The blood samples were obtained from patients and healthy donors by using kit for blood type identification, while the blood types of the deceased were taken from the hospital records. Several statistical tests were also conducted to find out the differences between the aforementioned groups. ANOVA was performed to investigate the correlation of ABO blood types with incidence of COVID-19 patients. The variables adopted in the analysis were age and sex. The study found that the difference between the association of each blood group with that of cases was significantly correlated (p = 0.00001). Out of total 975 patients 30.2% had blood group A, 27.3% had group B, 26.8% had group O and 15.7% had blood group AB. The study found that the number of recovered patients in 18-30 years age group was not significant among male and female population, while number of patients in other age groups in both male and female patients who finally recovered, was significantly lesser among patients with blood groups A and AB. There was a significant number of patients with blood group B in all the age groups except 31-35 years old. The study concluded that blood group B patients were severely affected by COVID-19.
Di Pedalaman Sulawesi
Authors: Kaudern Walter 
Published: December 2024

Ke Pipikoro
Kantewu
Sebuah Desa yang tidak ada
Peana
Kunjungan ke Benahu
Ke Tobaku dan Tole
Di dalam pusat Sulawesi Tengah
Behoa
Di sekitar Kulawi
Lindu

Dari Jilid II cetakan asal.

Kerajinan dan seni bangunan di barat laut Sulawesi Tengah
Pakaian dan perhiasan masyarakat pegunungan di barat laut
Seni
Di Pedalaman Sulawesi
Authors: Kaudern Walter 
Published: December 2024

Di Pedalaman Sulawesi JILID III - TERAKHIR
Budaya Batu, Ondae, Mori, Luwuk, Lamala, Loinang, Banggai, Buton
Vol. 6 No. S5 (2022)
DENGAN 338 ILUSTRASI, 15 PELAT WARNA DAN 18 PETA
Walter Kaudern (1881-1942) adalah seorang Ahli Zoologi dan Etnografer asal Swedia yang melakukan perjalanan penelitian ke Sulawesi Utara dan Tengah antara tahun 1917 dan 1921. Perjalanan tersebut dimulai dengan fokus pada pertanyaan-pertanyaan Zoologi yang banyak dicari di Sulawesi Utara, namun dengan cepat beralih ke permasalahan etnografis di Sulawesi Tengah. Di sini, ia bekerja dalam waktu lama di Kulawi, dan Loinang, dengan kunjungan sampingan komparatif di Pipikoro, Bada' dan Ondae, mengumpulkan 3000 koleksi artefak yang kini disimpan di Museum Kebudayaan Dunia Swedia (Gothenburg). Hasil penelitian lapangannya ia publikasikan dalam bahasa Inggris dalam 6 jilid ekstensif "Kajian Ethnographi di Sulawesi: Hasil Ekspedisi Penulis ke Sulawesi 1917-1920 (1925-45), beberapa jilid di antaranya telah diterjemahkan dalam LOBO.
Namun Di Pedalaman Sulawesi, merupakan karya survei awal yang diterbitkan dalam bahasa Swedia sehingga tidak dapat diakses oleh sebagian besar pembaca. Pentingnya karya ini bukan terletak pada laporan temuan zoologi dan etnografisnya yang dilaporkan secara panjang lebar di tempat lain, namun pada refleksi pribadinya yang mendalam terhadap penelitian dan metodenya, dan khususnya interaksinya dengan pemerintah kolonial Belanda, Salvation Army Missionaries, dan khususnya penduduk Sulawesi Tengah. Ini bukanlah potret diri yang puji diri.
Karya ini akan diterbitkan dalam tiga volume, dan berisi link luas ke koleksi foto yang tersedia di Museum Kebudayaan Dunia (Gothenburg).
Pembaca diperingatkan bahwa karya ini mengandung bahasa rasis.
LAOLITA i WALI mPANGIPI
Authors: Adriani Nicolaus , Schrauwers Albert 
Published: December 2024

Cerita, teks dan terjemahan Wali mPangipi yang disediakan di sini, berasal dari negara bagian Tojo, dan dengan demikian memiliki tradisi sastra yang sama dengan Sese nTaola. Diceritakan kepada saya oleh seseorang bernama Pake, seorang Tojo, seorang budak milik Sa'ungkubi, atau dikenal sebagai Papa i Melempo. Cerita ini saya transkrip di Poso pada saat panen raya (Agustus) tahun 1897. Sebagai sebuah karya sastra, Wali mPangipi tentu kualitasnya lebih rendah dari Sese nTaola. Meskipun, secara keseluruhan, cerita ini dibangun lebih baik daripada Sese nTaola, karena yang terakhir tiga kali lebih panjang, cukup banyak bakat yang dibutuhkan dalam menghasilkan cerita yang panjang daripada kasus Wali mPangipi.
Konstruksi Relasi Kesejahteraan Hakim Dengan Kualitas Kinerja Yudisial Yang Berkeadilan
Authors: Lutfianingsih Fifit , Jonaedi Efendi  
Published: December 2024

Hubungan kesejahteraan hakim dengan kualitas putusan menjadi legal issue yang menarik. Disamping secara teoritik belum banyak yang membahas, juga secara empiris topik ini menjadi pembicaraan massif khususnya di kalangan para hakim. Artikel ini menjadi salah satu kontribusi penting dan original untuk mengisi kekosongan penelitian terkait relasi kesejahteraan hakim dengan kualitas putusan. Penelitian didasarkan pada tiga rumusan masalah 1) Bagaimana pandangan hakim terkait gaji saat ini dan gaji yang diharapkan? 2) Bagaimana relasi dan pengaruh antara kesejahteraan hakim dengan kualitas putusan? 3) Bagaimana konstruksi relasi kesejahteraan hakim dengan kualitas putusan yang berkeadilan?. Penelitian ini termasuk dalam penelitian hukum empiris dengan pendekatan socio legal. Adapun teknik pengumpulan bahan hukum dan data diperoleh dengan wawancara mendalam terhadap responden yang telah ditetapkan dengan teknik purposive sampling. Temuan studi menghasilkan; Pertama, kesejahteraan hakim masih relatif kurang, hal ini dilihat dari sisi tanggung jawab profesi dan beban kerja serta dari beberapa perbandingan gaji hakim di beberapa negara. Kedua, terdapat hubungan tidak langsung antara kesejahteraan hakim dengan kualitas putusan dan hubungan keduanya berpengaruh positif. Ketiga, konstruksi relasi positif antara kesejahteraan hakim dengan kualitas putusan. Hal ini dilegitimasi secara teoritik baik dari perspektif teori ekonomi maupun realisme hukum. Sedangkan secara empiris disimpulkan bahwa meskipun kesejahteraan hakim tidak menjadi instrumen untuk menghasilkan putusan yang berkeadilan tetapi secara empiris kesejahteraan hakim adalah sebuah keniscayaan.