bluuebunny/crossref_metadata_2025_split huggingface dataset:
Buds of Santonian magmatism associated with Marion hotspot in southern India
Authors: Shaji E. , Santosh M. , Li Shan‐Shan , Manikyamba C. , Tsunogae T. , Dhanil Dev S.G. , Panicker Arathi G. , Dhanakumar Singh Th. , Subramanyam K.S.V. 
Published: December 2018

Imprints of Marion hotspot magmatism representing the final stages of rifting between India and Madagascar from the Gondwana assembly occur scattered in several localities of southern India. In this study, we report evidence for rift‐related Santonian magmatism from alkali gabbro in the Madurai Block and present mineralogical, petrological, zircon U–Pb geochronological, and whole‐rock geochemical data on the Mundanmudi gabbroic complex. The rock shows mesocumulate textures with plagioclase laths forming the triple junctions and porphyritic texture with hornblende and clinopyroxene as phenocrysts. Geochemically, the gabbros are characterized by moderate to high SiO2 (50–58 wt.%), alkalies (4.14–7.00 wt.%), and high TiO2 (1.71–4.22 wt.%), with calc‐alkaline to high‐K alkaline affinity. Chondrite‐normalized REE patterns are highly fractionated with LREE enrichment relative to HREE and absence of Eu anomalies. The primitive mantle normalized trace element patterns have LILE enrichment relative to HFSE, exhibiting negative anomalies at Nb, Zr, and Ti. The HFSE relationships indicate a within‐plate tectonic setting for the genesis of these gabbros. The major element tectonic discrimination plots suggest MORB‐OFB affinity which is also supported by the Nb–Th relationship endorsing the divergent tectonic processes responsible for the generation of these gabbros. The zircon U–Pb mean age of ca. 85 Ma represents the magmatic emplacement age within a rift‐related tectonic setting during the Santonian (late Cretaceous). Based on the LREE and HREE relationship, it is inferred that the parental magma might have been derived at garnet lherzolite depths above the Marion plume, possibly correlatable with the large igneous province generated at this time in Madagascar. Our study provides new evidence for the final phase of the magmatism at ca. 85 Ma related to India–Madagascar rifting.
Adult type rhabdomyoma presenting as a parathyroid adenoma
Authors: Lee John P. , Blake Sullivan Christopher , Bayon Rodrigo , Shearer A. Eliot , Robinson Robert A. 
Published: December 2018

AbstractBackgroundAdult‐type rhabdomyoma (ATR) is a rare mesenchymal tumor of skeletal muscle differentiation. Extracardiac ATR occurs most commonly in the head and neck, but do so in a heterogeneous fashion, arising at numerous different locations within this region.MethodsAt our institution, we encountered a patient who was diagnosed clinically with parathyroid adenoma based on signs and symptoms of hyperparathyroidism and suggestive radiologic findings. A parathyroidectomy with intraoperative consultation was performed.ResultsThe frozen section diagnosis was ambiguous and a diagnosis of ATR was only made on permanent section.ConclusionAwareness of this tumor can prevent incorrect diagnosis and overtreatment intraoperatively. Herein, we describe the clinical history, pathologic findings, and review histologic features of rhabdomyomas.
Patterns of care and survival outcomes for laryngeal small cell cancer
Authors: Lin Alexander J. , Gabani Prashant , Fischer‐Valuck Ben , Rudra Soumon , Gay Hiram , Daly Mackenzie , Oppelt Peter , Jackson Ryan , Rich Jason , Paniello Randal , Zevallos Jose , Adkins Douglas , Thorstad Wade 
Published: December 2018

AbstractBackgroundTo determine practice patterns and outcomes of laryngeal small cell cancer (LSCC) across the United States.MethodsPatients with LSCC were identified in the National Cancer Database. Overall survival (OS) was compared with Kaplan‐Meier analysis and Cox regression.ResultsFrom 2004 to 2014, the 5‐year OS for early stage (n = 47), locally advanced stage (n = 133), and metastatic disease (n = 53) was 34%, 26%, and 9%, respectively. Chemoradiation was given in 66% of cases. Chemotherapy was less likely given in early stage disease (P = .001), and definitive radiation was less likely given in metastatic disease (P < .001). Definitive radiation improved median OS in locally advanced LSCC (20 vs. 7 months, log‐rank P = .04). In multivariable modeling, radiation dose ≥40 Gy was associated with better OS (P < .001).ConclusionChemoradiation was the most common practice for treating locally advanced LSCC, and radiation dose ≥40 Gy was associated with improved OS.
Characterization of head and neck squamous cell carcinoma arising in young patients: Particular focus on molecular alteration and tumor immunity
Authors: Ryu Hyang Joo , Kim Eun Kyung , Cho Byoung Chul , Yoon Sun Och 
Published: December 2018

AbstractBackgroundThe purpose of this study was to comprehensively characterize head and neck squamous cell carcinoma (HNSCC) arising in young patients (<45 years old).MethodsWe performed immunohistochemistry, silver, and fluorescence in situ hybridization using samples obtained from 396 radically resected cases among 1787 HNSCCs.ResultsYoung age HNSCCs occurred in 10.9% (194/1787) and were most common in the oral tongue (50.5%). They revealed distinctively lower frequency of p16 positivity, high c‐MET expression, MET copy number gain, and lower pan‐Trk expression. PD‐L1 positivity in tumor cells and ICOS+ tumor infiltrating lymphocytes (TILs) were higher in the young age. Perineural invasion, PD‐L1 positivity, and higher ratio of CD163+ tumor infiltrating macrophages to CD8 + TILs were determined to be independent factors for poor progression‐free survival.ConclusionCharacterizing these features of young age HNSCC may help to identify the underlying pathogenesis and to improve patient outcome through different treatment strategies.
Anti‐oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient‐derived tumor xenograft model
Authors: Yang Cheng‐Yu , Lin Chih‐Kung , Hsieh Cheng‐Chih , Tsao Chang‐Huei , Lin Chun‐Shu , Peng Bo , Chen Yen‐Tzu , Ting Chun‐Chieh , Chang Wei‐Chin , Lin Gu‐Jiun , Sytwu Huey‐Kang , Chen Yuan‐Wu 
Published: December 2018

AbstractBackgroundAberrant expression of decoy receptor 3 (DcR3) is considered to be a diagnostic and therapeutic target for human cancers. The aim of this study was to assess DcR3 as a target of the anticancer effects of triptolide (TPL) in preclinical patient‐derived tumor xenograft (PDTX) models of oral squamous cell carcinoma (OSCC).MethodsThe expression of DcR3 was evaluated through immunohistochemistry, and correlations were examined using clinical variables. The effects of TPL on the expression of DcR3 and cell proliferation were investigated in OSCC cell lines and in PDTX models.ResultsDcR3 overexpression was associated with overall survival and tumor size. TPL significantly decreased tumor growth. Moreover, TPL inhibited the expression of metastasis‐associated protein 1 (MTA1), a transcription factor for DcR3 in vivo, in vitro, and in PDTX models.ConclusionTPL appeared to exert anticancer effects by repressing DcR3 and MTA1 in vitro, in vivo, and in PDTX models.
Management of persistent juvenile angiofibroma after endoscopic resection: Analysis of a single institution series of 74 patients
Authors: Schreiber Alberto , Bertazzoni Giacomo , Ferrari Marco , Ravanelli Marco , Rampinelli Vittorio , Mattavelli Davide , El‐Naggar Ahmed , Nicolai Piero 
Published: December 2018

AbstractBackgroundManagement of persistent juvenile angiofibroma (pJA) after transnasal endoscopic resection is controversial. To better understand its behavior, optimize treatment, and minimize morbidity, we report our experience in pJA focusing on follow‐up strategies and disease progression.MethodsA retrospective review of clinical records of all JA cases treated with endoscopic surgery at the Unit of Otorhinolaryngology of the University of Brescia between January 1994 and October 2015 was performed.ResultsSeventy‐four cases were included. Mean follow‐up was 113 months (6‐266 months). Evolution of pJA was analyzed in 6 cases. Residual lesion size significantly decreased in 3 cases and 2 lesions did not show size variations; significant growth was detected in 1 case of intentional pJA, with diameter increasing by 2.2 mm/yr.ConclusionspJAs may have the tendency to regress spontaneously or remain stable. In selected cases, avoiding treatment of nongrowing pJA in critical areas is a prudent option.
Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma
Authors: Munguía‐Calzada Pablo , Fernández‐Vega Iván , Martínez‐Camblor Pablo , Díaz‐Coto Susana , García‐Pedrero Juana María , Vivanco Blanca , Osuna Cristina Galache , Vazquez‐Lopez Francisco , Rodrigo Juan Pablo , Santos‐Juanes Jorge 
Published: December 2018

AbstractBackgroundFocal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC).ObjectiveTo investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients.MethodsFAK and cortactin expression was analyzed by immunohistochemistry on paraffin‐embedded tissue samples from 100 patients with cSCC, and correlated with the clinical data.ResultsFAK overexpression was a significant risk factor for nodal metastasis with crude and adjusted ratios (HRs) of 2.04, (95% CI [1.08‐3.86], [P = 0.029]) and 2.23 (95% CI [1.01‐4.91], [P = 0.047]), respectively. Cortactin expression was not a significant risk factor for nodal metastasis.ConclusionThese findings demonstrate that FAK overexpression is an independent predictor of nodal metastasis that might be helpful for risk stratification and management of patients with cSCC.
Water and air dynamics within a deep vadose zone of a karst massif: Observations from the Lukina jama–Trojama cave system (−1,431 m) in Dinaric karst (Croatia)
Authors: Stroj Andrej , Paar Dalibor 
Published: December 2018

AbstractExtreme heterogeneity of karst systems makes them very challenging to study. Various processes within the system affect its global response, usually measured at karst springs. Research conducted in caves provides a unique opportunity for in situ analysis of separate processes in karst underground. The aim of the present study was to research the water and air dynamics within a deep karst system. Air and water basic physical parameters across the Lukina jama–Trojama cave system (−1,431 m) were continuously monitored during a 1‐year period. Recorded hydrograph of the siphon lake at the bottom of the cave was used to interpret the characteristics of an unexplored phreatic/epiphreatic conduit network. Water origin in the siphon was determined based on temperature and electrical conductivity. Air temperature and humidity monitoring revealed a strong inflow of air of sub‐zero temperature into the upper portion of the cave during winter. Cave passage morphology was interpreted as the main determinant of air dynamics, which caused ice to accumulate extensively in the upper portions of the cave and caused the temperature on the top of the homothermic zone to be significantly below the mean outside temperature. Air dynamics also lowered the temperature of water flowing through the cave vadose zone and feeding the phreatic zone of the massif. The pronounced temperature difference between the phreatic zone and the top of the homothermic zone probably contributed to the thermal gradient observed in the cave, which is steeper than in ice‐free caves in the area. Our results enabled the development of a conceptual model that describes coupling between air and water dynamics in the cave system and its surroundings.
Assessing the Regional Water‐Saving Irrigation Management Level: A Case Study in Sichuan Province, China
Authors: Liu Liwen , Zhang Lili , Wang Chunyi , Cui Ningbo , Zhao Lu , Liang Chuan 
Published: December 2018

AbstractThe regional water‐saving irrigation management level (WIML) varies due to the differences in natural conditions and economic levels in different regions, so how to screen reasonable evaluation indexes and build a scientific and comprehensive WIML evaluation model is of great significance. In this paper, we selected 14 indexes (both qualitative and quantitative) from 4 aspects of water‐saving administrative management, engineering management, water use management and operation management to set up an evaluation index system of WIML in 21 cities (states) of Sichuan Province, a large agricultural province in China. The objective weight determined by the entropy weight method and subjective weight determined by the analytic hierarchy process method were combined to judge the relative importance of each index. Furthermore, the set pair analysis method was applied to evaluate WIML in different regions. Results show the overall management level of water‐saving irrigation in Sichuan Province was ‘general’; 43% regions were at the ‘good’ level; 43% of regions were at ‘general’ and ‘poor’ level; 14% of regions were at the ‘poorer’ level. WIML varied in different cities (states), and Sichuan Province had great potential for improvement of WIML. Although the evaluation criterion and method will be further improved in other regions or in the future, the study provided the theory foundation for improving the water‐saving irrigation management level in Sichuan Province. © 2018 John Wiley & Sons, Ltd.
Catalytic steam‐gasification of biomass in a fluidized bed reactor
Authors: Zhou Liang , Yang Zhiyong , Tang Anjiang , Huang Hongsheng , Lu Wei 
Published: December 2018

AbstractBACKGROUNDThe depletion of fossil fuels and the increasing demands for clean energy, make biomass energy a promising sustainable alternative to fossil fuels. Biomass gasification is a promising pathway for producing gas and other valuable products using biomass materials (wood residue, agricultural waste, bagasse, etc.).RESULTSThe tar cracking and char conversion increased slowly at lower temperatures (750–800 °C) and rapidly at higher temperatures (800–900 °C). The results also indicated that a reduction in the biomass particle size leads to a slight improvement in the gasification characterstics. With increasing steam–biomass ratio, gas yield increased while the yield of tar and char showed an opposite trend.CONCLUSIONIncreasing temperature and steam introduction significantly promoted tar destruction and gas production. In terms of catalytic activity, both catalysts showed good performance regarding the destruction of tars but dolomite was more active than olivine. © 2018 Society of Chemical Industry
Economic and environmental sustainability of low‐carbon power generation: relevancy in the Malaysia Green Technology Master Plan (GTMP)
Authors: Abdul Manaf Norhuda , Abbas Ali 
Published: December 2018

AbstractBACKGROUNDThe Malaysia Green Technology Master Plan (GTMP) is a systematic framework and planning initiative to mitigate national CO2 footprints by targeting several sectors which include power generation (energy sector). Thus, the objective of this study is to analyze economic and environmental sustainability (via techno‐economic analysis) of CO2 mitigation technology (i.e. postcombustion CO2 capture system, PCC) that can be employed by the energy sector as a way forward for low‐carbon power generation.RESULTSThe analysis was performed by using a previously developed hybrid mixed integer nonlinear programming and model predictive control (MINLP‐MPC) algorithm. Based on the simulation results, operation of coal‐fired power plant associated with PCC plant under fixed forecast conditions (year 2020) would be capable of delivering substantial net operating revenue, subject to carbon taxes at US$7, 10 and 14 t–1 CO2 (scenarios 1–3), with the highest revenue gained from Scenario 1 (US$7 t–1 CO2) of US$601 million yr–1. Contrariwise, PCC plant operated at minimum efficiency by only capturing c.24% from the total CO2 emissions (under three carbon tax prices), illustrating the ineffectiveness of this plant for promoting national environmental sustainability.CONCLUSIONThe big trade‐off between economic and environmental sustainability found in this study demonstrates the impracticality of PCC technology as a mitigation measure in pursuing low‐carbon power generation as part of Malaysia's GTMP. © 2018 Society of Chemical Industry
TP53 somatic mutations are associated with somatic mitogenome substitutions but not indels in colorectal cancer cells
Authors: Skonieczna Katarzyna , Jawień Arkadiusz , Marszałek Andrzej , Grzybowski Tomasz 
Published: December 2018

AbstractBackgroundp53 is a tumour suppressor protein that is involved in many cancer‐related processes. Growing evidence suggests that p53 also plays an important role in mitochondrial (mtDNA) maintenance. Somatic mitogenome mutations are frequently observed in colorectal cancer (CC) cells. Thus, it was important to determine whether somatic mtDNA changes are associated with TP53 mutational status.MethodsIn the present study, we analysed the TP53 gene in 67 CC patients, for whom mitogenome haplotypes were previously described. In total, 134 TP53 sequences (of cancer and matched normal specimens) were determined using the dideoxy method.ResultsNine hereditary polymorphisms in the TP53 gene were detected in normal colon cells. None of them (neither alleles, nor genotypes) was associated with somatic mitogenome mutations in CC cells. Moreover, 42 somatic TP53 mutations were found in approximately 36% of CC tissues. These somatic changes were significantly more frequent in CC cells with somatic mtDNA mutations (p = 0.0069). Furthermore, we show that only mitochondrial somatic substitutions (p = 0.0017), but not indels (p > 0.05), were associated with somatic TP53 mutations.ConclusionsThe results of the present study suggest that changes in TP53 may modify p53 properties, which may result in the accumulation of somatic substitutions in CC mitogenomes.
Leader‐signaled knowledge hiding: Effects on employees' job attitudes and empowerment
Authors: Offergelt Florian , Spörrle Matthias , Moser Klaus , Shaw Jason D. 
Published: December 2018

SummaryThe authors introduce the concept of leader‐signaled knowledge hiding (LSKH) and conduct two studies observing what happens when leaders signal employees that knowledge hiding (KH) is practiced, tolerated, and expected. Social learning theory provides the basis for predicting that LSKH encourages subordinates to hide knowledge, even though they suffer from negative job attitudes in reaction. In Study 1, data measured at two time points (N = 1,162) shows that LSKH positively predicts KH among subordinates. The KH dimensions of evasive hiding and playing dumb (but not rationalized hiding) negatively relate to job satisfaction and positively affect turnover intentions. Study 2 (N = 1,169) replicates these results with cross‐sectional data. Moreover, Study 2 demonstrates that evasive hiding and playing dumb negatively affect empowerment, whereas rationalized hiding has a positive effect. Both studies reveal that subordinates will show less KH when they work under leaders who avoid LSKH and in turn have more job satisfaction, feel more empowered, and harbor fewer turnover intentions. The results in this study provide important practical implications for knowledge management activities.
Characterization of 20th century art materials from the Lasar Segall Museum
Authors: Mendes Isolda de Castro , dos Santos Oliveira Juliana Alves , Dantas Maria Sylvia Silva 
Published: December 2018

AbstractThis article describes the first results of a study of the collection of art materials, painted works, and techniques, belonging to the Lasar Segall Museum in Brazil, using materials and documents of the early 20th century. The paint materials from the museum's collection consist of over a hundred glass vases, tubes, and packets containing powdered pigments, inks, oils, and varnishes. Powdered and dried ink (labeled “ink for posters”) samples were analyzed using confocal Raman microscopy spectroscopy, Fourier transform infrared spectroscopy, energy‐dispersive X‐ray fluorescence, and X‐ray diffraction. The artist's palette chromophores such as ultramarine, cobalt and Prussian blue, goethite, hematite, and magnetite from natural ochres, lead basic carbonate, lead carbonate, anatase, zinc carbonate hydroxide, zinc oxide, lead chromate, carbon, cadmium sulfide, copper acetate arsenite, verditer, celadonite, serrabrancaite, vermilion, PY1, PY3, PR3, and PO5 were identified mainly by Raman spectroscopy. The color palette found in paintings from 1919 is closely related to the characterized pigments from the museum. Nevertheless, the violets found are not mineral in nature but organic. The descriptions of the results for each sample and painting were made available to the museum to assist in future conservation, dating, and authentication procedures of the works.
Assessment of rip lines using CAESAR‐Lisflood on a trial landform at the Ranger Uranium Mine
Authors: Saynor Mike J. , Lowry John B.C. , Boyden James M. 
Published: December 2018

AbstractThe Ranger Mine in the Northern Territory of Australia is to be rehabilitated by 2026. The rehabilitated landform will require some form of erosion control, or surface amelioration to reduce water and sediment leaving the landform. One method of surface amelioration is the construction of rip lines. Rip lines have been used in both mining and agricultural environments to reduce surface water velocity, trap fine sediment and nutrients, and reduce erosion from the landform. However, there is little quantitative information on the extent to which rip lines influence erosion. In a desktop study using the CAESAR‐Lisflood landform evolution model, we assessed the effectiveness of rip lines by simulating the evolution of both ripped and nonripped surfaces on a range of slopes from 2% to 12% for simulated periods of up to 50 years.We found that rip lines are most effective at controlling erosion on slopes of up to 4%. However, this study also demonstrated that as slope increases, rip lines become less effective over time. These results, in the context of the proposed rehabilitated landform for Ranger Mine, on which the majority of slopes will be between 2% and 4%, indicate that rip lines would be an effective way of mitigating soil loss and sediment transport. Furthermore, model simulations of ripped surfaces show that the structure of the rip lines break down over time, with the rip line depressions infilling and the peaks being eroded, lowered, or reduced in height. This finding is important because it demonstrates that rip lines will not exist in perpetuity in the landscape and long‐term erosion control plans cannot be based on their existence.