bluuebunny/crossref_metadata_2025_split huggingface dataset:
OPTI-HEP-D: a protocol for an intervention study comprising screening and linkage to care of people living with hepatitis D in Catalonia
Authors: Palom Adriana , Rando-Segura Ariadna , Fernandez Gema , Calatayud Laura , Sellés-Sánchez Alicia , Pérez del Campo Dúnia , Mormeneo Bayo Saray , Perez Moreno Maria Mar Olga , Tabernero David , Ayats Josefina , Llopis Maria Antonia , Quer Juan Carlos , Buti Maria 
Published: November 2024

IntroductionHepatitis B virus (HBV) affects 296 million people globally, causing 780 000 annual deaths. It has been estimated that 12–43 million individuals are co-infected with hepatitis D virus (HDV). In Spain, the prevalence of HBsAg in adults is 0.22%, with an anti-HDV prevalence of 7.7%, although not extensively documented since many HBsAg-positive cases are not tested for anti-HDV. The primary objective of this project is to optimise hepatitis D care by implementing a screening programme for anti-HDV in all HBsAg-positive individuals over a 1 year period in Catalonia. Secondary objectives include evaluating hepatitis D prevalence, establishing a digital registry for all anti-HDV positive cases, testing them for HDV-RNA in a centralised laboratory and offering linkage to care.Methods and analysisThis prospective study will be performed in seven hospital centres in Catalonia, which attend to more than 95% of the adult population. Approximately, 9290 HBsAg-positive individuals are expected to be screened for anti-HDV in 1 year. All anti-HDV positive samples will be sent to a centralised laboratory for HDV-RNA quantification. All individuals testing positive for anti-HDV will be registered on an electronic platform and linked to care. The registry will collect data on demographics, infection stage, risk factors, disease awareness and previous diagnoses. No additional interventions will be conducted for those with adequate follow-up.Ethics and disseminationThe Vall d’Hebron Hospital Ethics Committee (PR(AG)628/2023) and the Spanish Agency of Medicines and Medical Devices approved this study. These findings will be disseminated through peer-reviewed publications and conference presentations.Trial registration studyGrant number: IN-ES-980–7058.
Development of the Ontario Hereditary Cancer Research Network, a unified registry as a resource for individuals with inherited cancer syndromes: an observational registry creation protocol
Authors: Farncombe Kirsten M , Hughes Lauren K , Tuzlali Elif , Akbari Mohammad Reza , Andrulis Irene L , Aronson Melyssa , Bell Kathleen , Brazas Michelle D , Cable-Cibula Melissa , Chan Brandon , Courtot Melanie , Feilotter Harriet , Harland Jamie , Lark Katie , Lerner-Ellis Jordan , MacDougall Ellen , Malkin David , Narod Steven A , Panabaker Karen , Radvanyi Laszlo , Rusnak Alison , Stein Lincoln , Kim Raymond H 
Published: November 2024

IntroductionIn Canada, care for individuals with hereditary cancer is fragmented across the provinces and territories, with carriers of pathogenic variants in cancer-susceptibility genes seeing multiple doctors and often advocating for their own management plans. The need for a national registry of carriers has been well established. While other cancer consortia exist, barriers in clinical and genomic data sharing limit the utility of the information gathered.Methods and analysisWithin the province of Ontario, the Ontario Hereditary Cancer Research Network (OHCRN), funded by and located at the Ontario Institute for Cancer Research, is being developed to fill this gap. The registry will hold clinical, genomic and self-reported data from consented carriers and will make this data available to qualified researchers in anonymised and aggregated form. Individuals must agree to certain components to participate in OHCRN; there are also optional consents participants can agree to without impacting their involvement in OHCRN. We plan to open the registry for participant enrolment in mid-2025.Ethics and disseminationEthics approval for registry creation was obtained from the Ontario Cancer Research Ethics Board, a centralised body that streamlines reviews for cancer research studies in Ontario. Registry data will be disseminated to participants and researchers as aggregate data through the OHCRN website and presented at scientific conferences, made available to Ontario Health (Cancer Care Ontario) to inform policy and evidence-based practice, as well as be available to the scientific community for further analysis and answering relevant questions.
Exploring the influence of nurses’ demographics and hospital work environment on medical error reporting practices in Jordan: a cross-sectional study
Authors: Dalky Ala’a , Oweidat Islam Ali , Abuzaid Sajeda Ramadan , Khalifeh Anas Husam , AlBashtawy Mohammed 
Published: November 2024

ObjectiveNurses have a significant role in maintaining patient and healthcare safety. Thus, healthcare administrators should focus on nurse performance and create a friendly hospital work environment to ensure patient safety and healthcare quality. Limited studies have investigated the impact of nurses’ demographics on nurses’ error reporting practices and nurses’ perceptions of the hospital work environment, especially in Jordan. This study aims to investigate the factors influencing nurses’ medical error reporting practices in Jordan, specifically focusing on the role of nurses’ demographics and the hospital work environment.Design:This is a descriptive cross-sectional study.SettingData collection was done in three hospitals (public, university-affiliated and private) in Jordan, using surveys that included demographics, the incident reporting practice scale and the Practice Environment Scale-Nursing Work Index from 11 June 2023 to 13 August 2023.Participants350 nurses with a diploma, associate degree, bachelor’s degree or postgraduate degree had worked at the targeted hospitals for at least 6 months and were responsible for direct inpatient care.Primary outcome measureThe level of medical error reporting practices and the nursing work environment. Also, differences were assessed among demographic characteristics and investigated the factors for medical error reporting practices.ResultsJordanian nurses had low medical error reporting practices (M=2.34; SD=0.57) and nursing work environment (M=2.4; SD=0.56). Nurses who were single and in private hospitals had higher medical error reporting practices (p<0.05). Medical error reporting practices positively correlated with the nursing work environment (r=0.807, p<0.01) and negatively correlated with the average number of patients per shift (r=−0.109, p<0.05). The nursing work environment was a significant predictor, with an 81.0% variance in medical error reporting practices.ConclusionsThe study found that Jordanian nurses have low perceptions of their work environment and medical error reporting practices, which are influenced by marital status and hospital type. Enhancing the nurse work environment and providing ongoing standards training are critical for improving safety behaviours, patient outcomes and care quality. Future research should investigate the long-term consequences of interventions on reporting practices and patient outcomes.
Impact of suspected preterm labour in foetal cardiovascular and metabolic programming: a prospective cohort study protocol
Authors: Abadía-Cuchí Natalia , Clavero-Adell Marcos , González Jesús , Medel-Martinez Ana , Fabre Marta , Ayerza-Casas Ariadna , Youssef Lina , Lerma-Irureta Juan , Maestro-Quibus Pilar , Rodriguez-Calvo Jesús , Ruiz-Martinez Sara , Lerma Diego , Schoorlemmer Jon , Oros Daniel , Paules Cristina 
Published: November 2024

IntroductionSuspected preterm labour (SPL) is an obstetric complication that occurs in 9% of all pregnancies and is the leading cause of antenatal hospital admissions. More than half of women with SPL deliver a premature baby which is a known risk factor for developing cardiovascular and metabolic disorders in childhood and later in adult life. On the other hand, the other half of these women will deliver at term, labelled as ‘false preterm labour’. Although this has been thought to be a benign condition, accumulating evidence reported in recent years showed long-term effects for the foetus, neonate and infant even when birth occurs at term. However, the impact of SPL on cardiovascular and metabolic programming has not been studied yet. The aim of this prospective cohort study is to evaluate the impact of SPL on cardiac remodelling and function and on cardiovascular and metabolic profiles independently of gestational age at birth.Methods and analysisProspective cohort study of subjects exposed and not exposed to an episode of SPL. Women with singleton pregnancies who are admitted at a tertiary hospital due to SPL and matched controls will be recruited. Evaluation of cardiovascular remodelling by foetal echocardiography will be performed during admission. Cord blood will be collected at birth in order to analyse different metabolomic footprints and several cardiovascular and metabolic risk biomarkers. Moreover, children will undergo an echocardiography 6 months after birth. The relationship between SPL and cardiovascular and metabolic programming will be modelled considering different covariates such as socioeconomic factors, perinatal characteristics, lifestyle, diet and exercise.Ethics and disseminationEthical approval was granted in April 2020 from CEIC Aragón (CEICA) (C.P.-C.I. PI20/136). Study outcomes will be disseminated at international conferences and published in peer-reviewed scientific journals.Trial registration numberNCT05670665.
Implementation outcomes of convergence action policy to accelerate stunting reduction in Pidie district, Aceh province, Indonesia: a qualitative study
Authors: Sufri Sofyan , Iskandar Iskandar , Nurhasanah Nurhasanah , Bakri Saiful , Jannah Misbahul , Rajuddin Rajuddin , Nainggolan Sarah Ika , Sirasa Fathima , Lassa Jonatan Anderias 
Published: November 2024

ObjectivesThe research aims to understand the challenges and opportunities in policy and programme convergence to accelerate interventions for reducing stunting at the district, subdistrict and the 10 focused villages.DesignData were collected through qualitative methods (in-depth interviews and document reviews), and then analysed using thematic processes with NVivo V.11 software, by QSR International The process included coding, categorising and linking to the eight implementation outcome variables (as determined themes), namely acceptability, adoption, appropriateness, feasibility, compliance, implementation cost, coverage and sustainability. The variables of convergence action policies were implemented differently by stakeholders at different layers of governance.SettingPidie district, Aceh province, Indonesia.Participants106 respondents from provincial to village levels were selected and interviewed, including leaders and policymakers (n=10); and convergence action implementers from the province to the villages (n=96).ResultsStunting reduction policies were generally acceptable to local leaders and policymakers as a policy imperative. Implementation costs were considered sufficient by stakeholders, although focusing only on nutrition-specific interventions. However, in terms of adoption, feasibility, compliance, nutrition-sensitive intervention coverage and sustainability aspects were insufficiently implemented in all the focused villages due to inadequate collaboration between health and non-health sectors and limited experts.ConclusionsThis study offers key recommendations for policy and practice changes and considerations. The utilisation of methods and findings from this study in other areas in Indonesia or other low- and middle-income countries is important to explore more about the applicability, benefits and weaknesses of this study.
Tushirikiane-4-Uthabiti (Supporting Each Other For Resilience): study protocol of a mental health, HIV self-testing and livelihoods randomised controlled trial for advancing HIV prevention outcomes among urban refugee youth in Kampala, Uganda
Authors: Logie Carmen H , Okumu Moses , Tailor Lauren , MacKenzie Frannie , Admassu Zerihun , Hakiza Robert , Kibuuka Musoke Daniel , Katisi Brenda , Nakitende Aidah , Kyambadde Peter , Mbuagbaw Lawrence 
Published: November 2024

IntroductionResearch with urban refugee youth in Uganda has documented co-occurring social (e.g., poverty) and health (e.g., depression) disparities associated with HIV vulnerabilities. Benefits of HIV self-testing (HIVST) in increasing HIV testing uptake among youth are well established, yet limited interventions have examined if combining HIVST with mental health promotion, or with mental health promotion alongside poverty reduction, is associated with greater improvements in HIV prevention and testing outcomes.Methods and analysisThe aim is to evaluate the effectiveness of: (1) HIVST alone (standard of care); (2) mobile health (mHealth) and graphic medicine (comic) programme for mental health alongside HIVST; and (3) the combination of HIVST, a livelihoods programme, and mHealth mental health programme, in advancing the primary outcome of HIV testing uptake and secondary outcomes (HIV status knowledge, linkage to confirmatory testing and HIV care, HIV knowledge, consistent condom use, condom use self-efficacy, sexual risk) with urban refugee youth in Kampala, Uganda. A three-arm randomised controlled trial will be implemented from 8 April 2024 to 31 October 2024 with youth across five informal settlements in Kampala, grouped into three sites based on proximity, and randomised in a 1:1:1 design. Approximately 330 participants (110 per arm) are enrolled and data collection will occur at three time points (baseline enrolment, 3-month follow-up and 6-month follow-up).Ethics and disseminationThe study received ethical approval from the University of Toronto (#37496), Mildmay Uganda Research Ethics Committee (#MUREC-2021-41) and Uganda National Council for Science & Technology (#SS1021ES). The trial is registered at ClinicalTrials.gov (NCT06270160). Study findings will produce new knowledge of the impacts of a mental health programme, and a combined mental health and livelihoods programme, on improving HIV prevention outcomes among urban refugee youth in Kampala. Findings will be shared in peer-reviewed publications, conference presentations and in community dissemination.Trial registration numberNCT06270160(date of registration: 13 February 2024).Trial sponsorDr. Carmen Logie, carmen.logie@utoronto.ca.
Advanced Nurse Practitioner (ANPs) experiences of the Quality and Outcomes Framework (QOF) Scheme: a UK case study
Authors: Khan Nagina , Peckham Stephen 
Published: November 2024

ObjectivesThe primary focus of pay-for-performance (P4P) schemes in the UK has traditionally been related to the public health and inclusion elements related to the activities of doctors with comparatively less attention given to nursing care as a component of the scheme. However, nursing is an integral part of healthcare delivery in the National Health Service and nurses constitute the major group of healthcare professionals in most countries. Our aim was to explore advanced nurse practitioner (ANPs) experiences of the Quality and Outcomes Framework (QOF), using the Implicit Leadership Theory (ILT) frame.MethodsWe used a case study approach. Six articles on the QOF work were synthesised, focused on ANPs and their leadership potential in healthcare. Evidence showed that despite having importance in delivering the activities of QOF, nursing activities overlooked. We undertook a thematic synthesis of these papers, with a specific focus ANPs’ leadership development in Long Term Conditions (LTC) care within general practice and capacity to influence the healthcare system.FindingsSix themes were identified: (1) sensitivity, patient-centred care, context and continuity of care; (2) intelligence—leaders capable of making strategic decisions in healthcare settings, (3) dedication, trust, equity and equality, (4) dynamism of nursing, (5) tyranny, guise of teamwork, collaboration and (6) nursing and healthcare leadership.ConclusionsNurses in leadership roles created good working relationships, coped with conflicts and contributed to shared objectives and were sympathetic collaborators. Using the six ILT characteristics, we found that nurses were collaborators. Future P4P schemes should benefit from a collective lens of healthcare personnel when focusing on quality initiatives and improving the delivery of healthcare activities.
Patient discourses on real-time access to test results via hospital portals: a discourse analysis of semistructured interviews with Dutch patients
Authors: Hulter Pauline , Weggelaar-Jansen Anne Marie J W M , Ahaus Kees , Pluut Bettine 
Published: November 2024

ObjectiveReal-time access to test results on patient portals can have advantages and disadvantages for patients. It confronts patients with a complicated decision, namely whether to consult results before the medical consultation. To gain a deep understanding of patients’ decision-making processes, we unravelled three discourses about real-time access to test results, each of which articulates a different set of values, assumptions and arguments. Our research question was what patient discourses on real-time access to test results can be distinguished?DesignWe conducted discourse analysis on 28 semistructured interviews.SettingInterviews were conducted with patients who had (no) experience with real-time access to test results. Our participants were treated in different hospitals, and therefore, used different portals since Dutch hospitals can choose from suppliers for their patient portals.ParticipantsPatients with experience (n=15) and without experience (n=13) of real-time access to test results on a patient portal.ResultsWe identified three discourses: (1) real-time access as a source of stress, which highlighted how real-time access could cause stress due to the complexity of deciding whether to access test results, the incomprehensibility of medical language and the urge to repeatedly check if test results were available, (2) anxiety reduction through real-time access showed how real-time access can reduce stress by reducing waiting times and (3) real-time access for self-management showed how real-time access can give patients an opportunity for self-management because they can make informed decisions and are better prepared for the medical consultation.ConclusionOur study shows the plurality in opinions on real-time access, which helps in forming different strategies to inform and support patients in order to realise optimal use of real-time access.
Online health literacy resources for people with intellectual disability: protocol for a grey literature scoping review
Authors: Yeap Zhenmei , Keeley Jessica , Skoss Rachel , Hunt Susan , Kickett Angela , Saldaris Jacinta , Nevill Thomas , Downs Jenny 
Published: November 2024

IntroductionPeople with intellectual disability are at risk of poor physical and mental health. Risks to health are compounded by poor health literacy, that is, reduced capacity to access health services, respond quickly to changes in health status and navigate care pathways. Building health literacy skills is a strength-based way to increase health and optimise the use of healthcare services. The internet is a primary source of health information for many people, including people with intellectual disability and their families. This scoping review will aim to identify and collate online lay healthcare resources available to and developed for people with intellectual disability and their families and evaluate whether domains of health literacy are addressed.Methods and analysisThis review will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews guidelines. The proposed search strategy has three components. Resources will be identified by (1) reviewing disability organisation websites, (2) searching key disability and health terms in the Google search engine and (3) snowball sampling to identify additional resources through links in identified websites and resources. Resources will be selected if they are freely available, presented in or translatable into English, provide health information and are directed to people with intellectual disability or their family members. Extracted data will include descriptors of the source, format, area of health and targeted age range. Content relevant to domains of health literacy will be documented and gaps in available health information will be identified. Study findings will be presented in narrative, tabular and visual forms.Ethics and disseminationEthical approval will not be sought because primary data will not be collected. The results will be disseminated in peer-reviewed literature, as conference presentations, as a synthesised resource for people with intellectual disability and their families and in summary documents for health service managers and policymakers.
Low-value practices in primary care: a cross-sectional study comparing data between males and females in Spain
Authors: Mira José Joaquín , Carratalá-Munuera Concepción , García-Torres Daniel , Soriano Cristina , Sánchez-García Alicia , Gil-Guillen Vicente F , Vicente María Asunción , Pérez-Jover Mª Virtudes , Lopez-Pineda Adriana 
Published: November 2024

IntroductionOveruse of medical services is a challenge worldwide, posing a threat to the quality of care, patient safety and the sustainability of healthcare systems. Some data suggest that females receive more low-value practices (LVPs)—defined as medical interventions that provide little or no benefit to patients and can even cause harm—than males. This study aims to evaluate and compare the occurrence of LVPs in primary care among both males and females.DesignA retrospective study was conducted.SettingPrimary care in the Alicante province (Spain) during 2022.ParticipantsData were extracted from the digital medical records of 978 936 patients attended by 1125 family physicians across 262 primary healthcare centres in the Alicante province.Outcome measuresData on age, sex, diagnosis and treatment were extracted. The primary outcome measure was the frequency of 12 selected LVPs prescribed to male and female patients. These LVPs were expected to be relatively frequent occurrences with the potential to cause harm.ResultsA total of 45 955 LVPs were identified, of which 28 148 (5.27% of 534 603, CI95% 5.20–5.32) were prescribed to female patients and 17 807 (4.00% of 444 333, CI95% 3.95–4.06) to male patients (x², p value <0.0001). The most common LVPs were prescribing treatment for overactive bladder without excluding other pathologies that may cause similar symptoms (30.87%), using hypnotics without having a previous aetiological diagnosis in patients with difficulty maintaining sleep (14%) and recommending analgesics (NSAIDs, paracetamol and others) for more than 15 days per month in primary headaches that do not respond to treatment (13.33%).ConclusionsFuture clinical training, management and research must consider biological differences or those based on gender factors when analysing the frequency and causes of LVP.Trial registration numberNCT05233852.