bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of pharmaceutical care in patients with psoriatic arthritis using statutory health insurance data
Authors: Sondermann Wiebke , Ventzke Julia , Matusiewicz David , Körber Andreas 
Published: March 2018

SummaryBackgroundPsoriatic arthritis (PsA) is an inflammatory joint disease. Despite numerous health care research studies, there is hardly any data regarding the current state of pharmaceutical care of PsA patients in Germany.Study population and methodsBased on a systematic literature search and routine administrative data from the Rhineland/Hamburg (statutory) health insurance fund (“Allgemeine Ortskrankenkasse“, AOK), the present study provides an up‐to‐date overview of pharmaceutical care of German PsA patients. Selected were those in‐ and outpatients who – in the first or second quarter of 2014 – had been coded as having the diagnosis of psoriatic arthritis (L40.5+) according to the International Classification of Diseases (ICD‐10‐GM version 2015). On the basis of this “predefined cohort”, drug prescription data was subsequently analyzed for a five‐year period (January 1, 2010 to December 31, 2014).ResultsOverall, 3,205 AOK‐insured individuals (45 % male, 55 % female) were diagnosed with PsA. Mean age was 58.9 years; 53.7 % of PsA patients received systemic treatment. Nonsteroidal antiinflammatory drugs (NSAIDs) were the most frequently prescribed agents, followed by corticosteroids. Among patients on systemic treatment, 72.1 % were treated with disease‐modifying antirheumatic drugs (DMARDs); 20.9 % with a combination of DMARDs and biologics.ConclusionNot only does pharmacological treatment of PsA have to ensure adequate patient care aimed at preventing disease progression, it also has to be approached with economic responsibility.
Walking Together, Serving Justice and Peace
Authors: Tveit Olav Fykse 
Published: March 2018

AbstractAs the World Council of Churches (WCC) marks its 70th anniversary, this article focuses on the challenges it faces in its commitment to work for the unity of the church and for common service and witness for justice and peace in the world. Looking back on the experiences in the Reformation year 2017, it argues that it is time for the fellowship of churches to be accountable for what it has achieved and received from ecumenical dialogue, and to grow together in mutual accountability. At the same time, the statement by the WCC's 10th Assembly at Busan that “We intend to move together” emphasizes that ecumenism is not a static reality, but dynamic, involving the cooperation of the various churches and in interaction with people of good will of other communities.
The Way of Ecumenism: Gratitude and Commitment
Authors: Raiser Konrad 
Published: March 2018

AbstractThis address to the Ecumenical Kirchentag in Germany in 2003 takes as its starting point the symbol of the church as the people of God on the way together to describe the ecumenical movement. This is a path that leads out of the security of structures, relying on the promise of God as a response to the call of the gospel to faith and the path of discipleship – the way of pilgrimage as it was described by the World Conference on Faith and Order in 1993 in Santiago de Compostela. After looking back at the milestones on the ecumenical journey toward communion in life, faith, and witness, the address highlights the significance of a mutual recognition of baptism by churches as representing a “Copernican revolution” in ecumenical dialogue, in which churches would commit themselves to mutual accountability in matters of faith and church order.
Ecumenism and Evangelicalism: Where Are We?
Authors: Castro Emilio 
Published: March 2018

AbstractWhile the ecumenical movement, and particularly the World Council of Churches, must always be an inclusive forum where the richness of the total life of the Christian church is manifest, this article argues that evangelicals cannot give up the quest for church unity because that would mean ignoring a central aspect of the prayer of Jesus Christ. Looking at areas of convergence between the evangelical and the ecumenical movement, four areas are identified for further cooperation and dialogue: the authority of the Bible; mobilizing all churches for the evangelization of the whole world; the perspective of the poor; and the challenge of justice and peace.
Is It Still a Movement?
Authors: Blake Eugene Carson 
Published: March 2018

AbstractIn this address from 1971, the second general secretary of the World Council of Churches (WCC), Eugene Carson Blake, sets out the challenges facing the WCC at the beginning of the 1970s, identifying three key changes within the ecumenical movement: a shift in power and decision making away from the Protestant churches of North America and Western Europe; an organization more representative of churches in Africa, Asia, and Latin America, and of Orthodox churches; and the ecumenical involvement of the Roman Catholic Church. It goes on to set out how the WCC, particularly since its conference on Church and Society held in Geneva in 1966, has been attempting to make Christian faith and morals relevant to a world experiencing rapid social, economic, and political change.
Rethinking Diakonia and Transforming Our World
Authors: Leer‐Helgesen Arnhild 
Published: March 2018

AbstractThis article analyzes how ecumenical diakonia contributes to a critical view of the power dimension of the Sustainable Development Goals (SDGs). At the same time, it presents both the opportunities and the challenges the SDGs provide in rethinking diakonia and diaconal praxis. The commitment of the global community to the SDGs signifies a new context for diaconal praxis at local and international levels. In this article, power relations and the priority of the marginalized are presented as key concerns for rethinking diakonia in the current context. A model for diaconal reflection, based on perspectives from development studies and theology, is suggested as a tool for an interdisciplinary rethinking of diakonia aiming at renewed praxis in the context of the SDGs.
Samuel Kobia: Ecumenical, Passionate, Peacemaker
Authors: Stückelberger Christoph 
Published: March 2018

AbstractThis article discusses the role played by Samuel Kobia in the ecumenical movement and the World Council of Churches, of which he was general secretary from 2004 to 2009, and his involvement in peacemaking and mediation in Africa, especially in his home country of Kenya, in Sudan, and in South Sudan.
Genome Sequence of a Tomato-Infecting Tomato Mosaic Virus Isolate from Zimbabwe
Authors: Karavina Charles , Ibaba Jacques D. , Gubba Augustine 
Published: March 2018

ABSTRACT

A tomato-infecting tomato mosaic virus (ToMV) isolate was detected in Zimbabwe using lateral flow kits and double-antibody sandwich enzyme-linked immunosorbent assay. Next-generation sequencing and
de novo
assembly were subsequently performed to determine its genome sequence. The ToMV genome of the Zimbabwe isolate is the second to be reported in Africa.
Draft Genome Sequence of Methylovulum psychrotolerans Sph1
T
, an Obligate Methanotroph from Low-Temperature Environments
Authors: Oshkin Igor Y. , Miroshnikov Kirill K. , Belova Svetlana E. , Korzhenkov Aleksei A. , Toshchakov Stepan V. , Dedysh Svetlana N. 
Published: March 2018

ABSTRACT

Methylovulum psychrotolerans
Sph1
T
is an aerobic, obligate methanotroph, which was isolated from cold methane seeps in West Siberia. This bacterium possesses only a particulate methane monooxygenase and is widely distributed in low-temperature environments. Strain Sph1
T
has the genomic potential for biosynthesis of hopanoids required for the maintenance of intracytoplasmic membranes.
Full Genome Sequence of the Western Reserve Strain of Vaccinia Virus Determined by Third-Generation Sequencing
Authors: Prazsák István , Tombácz Dóra , Szűcs Attila , Dénes Béla , Snyder Michael , Boldogkői Zsolt 
Published: March 2018

ABSTRACTThe vaccinia virus is a large, complex virus belonging to thePoxviridaefamily. Here, we report the complete, annotated genome sequence of the neurovirulent Western Reserve laboratory strain of this virus, which was sequenced on the Pacific Biosciences RS II and Oxford Nanopore MinION platforms.
Evaluation of the congenital hypothyroidism screening programme in Iran: a 3-year retrospective cohort study
Authors: Mehran Ladan , Khalili Davood , Yarahmadi Shahin , Delshad Hossein , Mehrabi Yadollah , Amouzegar Atieh , Ajang Nasrin , Azizi Fereidoun 
Published: March 2018

ObjectiveTo evaluate the newborn screening programme for congenital hypothyroidism (CH) in Iran from diagnosis to management and follow-up for 3 years from 2011 to 2014.DesignRetrospective cohort.Setting and patientsSeventeen university districts were randomly selected from 30 provinces. Central data in each district were gathered and collectively analysed. Congenital hypothyroid subjects were followed for 3 years.Main outcome measuresProgramme coverage, screening and treatment age, recall rate, compliance to follow-ups.ResultsThe total number of births in 2011 was 501 726, of which 452 918 neonates (90.3%) were screened and 15 671 (3.46%) were recalled; 1085 (1:462, 0.22%) were confirmed as having CH (57.1%: permanent, 42.9%: transient) and followed for 3 years. Positive predictive value (PPV) for the first screening test was 6.9%. After the second screening, recall rate was reduced to 0.69% and PPV increased to 31.3%. Median age at screening was 6 (3–9) days and for 90.6% of patients treatment was initiated before 40 days of age with a median levothyroxine dosage of 25 µg/day; 131 (13.4%) were lost to follow-up. Mean number of follow-up visits over 3 years was 5.7 (95% CI 5.5 to 5.9) and 23% (n=225) had total compliance to all follow-ups. Median time for thyroid stimulating hormone normalisation was 45 days, 95% CI (41.1 to 48.8).ConclusionIn Iran, despite well-established protocols of screening and detecting CH subjects, stricter implementation of a structured system for monitoring and surveillance is needed to promote the management of patients and to reduce rates of loss to follow-up. Determining and addressing the causes of high false positive rates must be prioritised.
Pseudomonas aeruginosaisolation in patients with non-cystic fibrosis bronchiectasis: a retrospective study
Authors: Wang Hong , Ji Xiao-Bin , Mao Bei , Li Cheng-Wei , Lu Hai-Wen , Xu Jin-Fu 
Published: March 2018

ObjectivesPseudomonas aeruginosa (P. aeruginosa)occupies an important niche in the pathogenic microbiome of bronchiectasis. The objective of this study is to evaluate the clinical characteristics and prognostic value ofP. aeruginosain Chinese adult patients with bronchiectasis.MethodsThis retrospective and follow-up study enrolled 1188 patients diagnosed with bronchiectasis at Shanghai Pulmonary Hospital between January 2011 and December 2012. The patients’ clinical data including anthropometry, clinical symptoms, serum biomarkers, radiographic manifestations and lung function indices were reviewed. The median follow-up duration (IQR) was 44 (40-54) months, during which 289 patients were lost to follow-up. Data from 899 patients were collected and analysed for the outcomes of mortality, annual exacerbation frequency and health-related quality of life.ResultsP. aeruginosawas isolated from 232 patients, alongside other pathogens such asAspergillus(n=75) andCandida albicans(n=72). There were 74 deaths (12% of patients withP. aeruginosa, 7.3% of those without) over the course of the follow-up. The isolation ofP. aeruginosawas a risk factor for all-cause mortality (HR, 3.07; 95% CI 1.32 to 7.15) and was associated with high rates of exacerbations (ie, ≥3 exacerbations per year of follow-up) (HR, 2.40; 95% CI 1.20 to 4.79). Patients withP. aeruginosaalso had worse scores on the Hospital Anxiety and Depression Scale (anxiety, p=0.005; depression, p<0.001), the Leicester Cough Questionnaire (p=0.033) and the modified Medical Research Council scale (p=0.001) compared with those withoutP. aeruginosa.ConclusionsIsolation ofP. aeruginosain patients with bronchiectasis is a significant prognostic indicator and should be a major factor in the clinical management of the disease.
Impact of mammography screening programmes on breast cancer mortality in Switzerland, a country with different regional screening policies
Authors: Herrmann Christian , Vounatsou Penelope , Thürlimann Beat , Probst-Hensch Nicole , Rothermundt Christian , Ess Silvia 
Published: March 2018

IntroductionIn the past decades, mortality due to breast cancer has declined considerably in Switzerland and other developed countries. The reasons for this decline remain controversial as several factors occurred almost simultaneously, including important advances in treatment approaches, breast cancer awareness and the introduction of mammography screening programmes in many European countries. In Switzerland, mammography screening programmes (MSPs) have existed in some regions for over 20 years but do not yet exist in others. This offers the possibility to analyse its effects with modern spatiotemporal methodology. We aimed to assess the spatiotemporal patterns and the effect of MSPs on breast cancer mortality.SettingSwitzerland.ParticipantsThe study covers breast cancer deaths of the female population of Switzerland during the period 1969–2012. We retrieved data from the Swiss Federal Statistical Office aggregated on a small-area level.DesignWe fitted Bayesian hierarchical spatiotemporal models on death rates indirectly standardised by national references. We used linguistic region, degree of urbanisation, duration of population-based screening programmes and socioeconomic index as covariates.ResultsIn Switzerland, breast cancer mortality in women slightly increased until 1989–1992 and declined strongly thereafter. Until 2009–2012, the standardised mortality ratio declined to 57% (95% CI 54% to 60%) of the 1969–1972 value. None of the other coefficients of the spatial regressions had a significant effect on breast cancer mortality. In 2009–2012, no region had significantly elevated or reduced breast cancer mortality at 95% credible interval level compared with the national mean.ConclusionThere has been a strong reduction of breast cancer mortality from the 1990s onwards. No important spatial disparities were observed. The factors studied (urbanisation, language, duration of population-based MSP and socioeconomic characteristics) did not seem to have an influence on them. Low participation rates and opportunistic screening use may have contributed to the low impact of MSPs.
Born before arrival in NSW, Australia (2000–2011): a linked population data study of incidence, location, associated factors and maternal and neonatal outcomes
Authors: Thornton Charlene Eliza , Dahlen Hannah Grace 
Published: March 2018

ObjectivesTo determine incidence, associated factors, outcomes and geographical occurrence of born before arrival (BBA) in New South Wales, Australia.DesignA linked population data study involving population-based surveillance systems was undertaken for the years 2000–2011.SettingNew South Wales, Australia.ParticipantsAll women who underwent BBA compared with women who birthed in hospital/birth centre settings.ResultsDuring the time period, there were 1 097 653 births and a BBA rate of 4.6 per 1000 births. The BBA rate changed from 4.2 to 4.8 per 1000 births over time (p=0.06). Neonates BBA were more likely to be premature (12.5% compared with 7.3%), of lower birth weight (209.8 g mean difference) and/or be admitted to a special care nursery or neonatal intensive care unit (20.6% compared with 15.6%). The perinatal mortality rate was significantly higher in the BBA cohort (34.6 compared with 9.3 per 1000 births). Women in the BBA cohort were more likely to be in the lowest socioeconomic decile, multiparous, have higher rates of smoking (30.5% compared with 13.8%) and more likely to suffer a postpartum haemorrhage requiring transfusion than the non-BBA cohort (1.5% compared with 0.7%). The most commonly occurring complications for neonates were suspected infection (6.9%), hypothermia (6.9%), respiratory distress (5.4%), congenital abnormality (4.0%) and neonatal withdrawal symptoms (2.4%). BBA more commonly occurred in geographical areas where the distance to a maternity unit is >2 hours drive and in coastal regions where there is also a high rate of homebirth.ConclusionBBA occurs more frequently in multiparous women of lower socioeconomic status. There potentially is an effect of geography on the occurrence of BBA, as geographical area of high homebirth and BBA coexists, indicating that freebirth followed by an unplanned transfer to hospital may be occurring.
Protocol for the economic evaluation of a complex intervention to improve the mental health of maltreated infants and children in foster care in the UK (The BeST? services trial)
Authors: Deidda Manuela , Boyd Kathleen Anne , Minnis Helen , Donaldson Julia , Brown Kevin , Boyer Nicole R S , McIntosh Emma 
Published: March 2018

IntroductionChildren who have experienced abuse and neglect are at increased risk of mental and physical health problems throughout life. This places an enormous burden on individuals, families and society in terms of health services, education, social care and judiciary sectors. Evidence suggests that early intervention can mitigate the negative consequences of child maltreatment, exerting long-term positive effects on the health of maltreated children entering foster care. However, evidence on cost-effectiveness of such complex interventions is limited. This protocol describes the first economic evaluation of its kind in the UK.Methods and analysisAn economic evaluation alongside the Best Services Trial (BeST?) has been prospectively designed to identify, measure and value key resource and outcome impacts arising from the New Orleans intervention model (NIM) (an infant mental health service) compared with case management (CM) (enhanced social work services as usual). A within-trial economic evaluation and long-term model from a National Health Service/Personal Social Service and a broader societal perspective will be undertaken alongside the National Institute for Health Research (NIHR)–Public Health Research Unit (PHRU)-funded randomised multicentre BeST?. BeST? aims to evaluate NIM compared with CM for maltreated children entering foster care in a UK context. Collection of Paediatric Quality of Life Inventory (PedsQL) and the recent mapping of PedsQL to EuroQol-5-Dimensions (EQ-5D) will facilitate the estimation of quality-adjusted life years specific to the infant population for a cost–utility analysis. Other effectiveness outcomes will be incorporated into a cost-effectiveness analysis (CEA) and cost-consequences analysis (CCA). A long-term economic model and multiple economic evaluation frameworks will provide decision-makers with a comprehensive, multiperspective guide regarding cost-effectiveness of NIM. The long-term population health economic model will be developed to synthesise trial data with routine linked data and key government sector parameters informed by literature. Methods guidance for population health economic evaluation will be adopted (lifetime horizon, 1.5% discount rate for costs and benefits, CCA framework, multisector perspective).Ethics and disseminationEthics approval was obtained by the West of Scotland Ethics Committee. Results of the main trial and economic evaluation will be submitted for publication in a peer-reviewed journal as well as published in the peer-reviewed NIHR journals library (Public Health Research Programme).Trial registration numberNCT02653716; Pre-results.
Factors associated with polypharmacy in primary care: a cross-sectional analysis of data from The English Longitudinal Study of Ageing (ELSA)
Authors: Slater Natasha , White Simon , Venables Rebecca , Frisher Martin 
Published: March 2018

ObjectivesWhile older age and ill health are known to be associated with polypharmacy, this paper aims to identify whether wealth, body mass index (BMI), smoking and alcohol consumption are also associated with polypharmacy (5–9 prescribed medications) and hyperpolypharmacy prevalence (≥10 prescribed medications), among older people living in England.DesignCross-sectional study.SettingThe English Longitudinal Study of Ageing Wave 6 (2012–2013).Participants7730 participants aged over 50 years.Data synthesisTwo multivariate models were created. HR with corresponding 95% CI, for polypharmacy and hyperpolypharmacy, were calculated after adjusting for gender, age, wealth, smoking, alcohol consumption, BMI, self-rated health and the presence of a chronic health condition.ResultsLower wealth (lowest wealth quintile vs highest wealth quintile, adjusted HR 1.28; 95% CI 1.04 to 1.69, P=0.02) and obesity (adjusted HR 1.81; 95% CI 1.53 to 2.15, p<0.01) were significantly associated with polypharmacy. Increasing age (50–59 years vs 70–79 years, adjusted HR 3.42; 95% CI 2.81 to 4.77, p<0.01) and the presence of a chronic health condition (adjusted HR 2.94; 95% CI 2.55 to 3.39, p<0.01) were also associated with polypharmacy. No statistically significant association between smoking and polypharmacy (adjusted HR 1.06; 95% CI 0.86 to 1.29, P=0.56) was established; while, very frequent alcohol consumption (consuming alcohol >5 times per week) was inversely associated with polypharmacy (never drank alcohol vs very frequently, adjusted HR 0.64; 95% CI 0.52 to 0.78, p<0.01). The adjusted HR for hyperpolypharmacy was accentuated, compared with polypharmacy.ConclusionThis study has identified that lower wealth, obesity, increasing age and chronic health conditions are significantly associated with polypharmacy and hyperpolypharmacy prevalence. The effect of these factors, on polypharmacy and especially hyperpolypharmacy prevalence, is likely to become more pronounced with the widening gap in UK wealth inequalities, the current obesity epidemic and the growing population of older people. The alcohol findings contribute to the debate on the relationship between alcohol consumption and health.