bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using an interprofessional decision-making model to determine the level of collaborative decision-making in a virtual learning environment
Authors: Beckingsale Louise , Morgan Sonya , Duffull Stephen , Hider Phil , McDermott Louise , Peterson Aynsley , McKinlay Eileen 
Published: October 2024

Medicine and pharmacy students benefit from interprofessional education that supports the learning of collaboration skills for medicines management decision-making. However, if and how students undertake collaborative decision-making processes in interprofessional student teams has not been investigated. The aim of this study was to determine the level to which pharmacy and medical students collaborate to make medicines management decisions in a learning activity.
Eight pharmacy and 13 medical students completed a 9-item survey to evaluate a interprofessional learning activity. A secondary analysis of survey data using a deductive approach, according to the Model of Interprofessional Decision-Making was undertaken.
Different levels of collaboration were identified in the students’ responses ranging from the first and lowest level in the model, Individual Decision Making, to the fourth and highest level, Shared Decision. Most student responses were categorised as level three-Deliberation.
Findings from this study indicate that pharmacy and medical students collaborate to different levels with each other to make patient care decisions. Further examination is required to see if this is usual variation or related to the design of the learning activity.
Semen Analysis of Covid-19 Survivors and Uninfected Men: Examining the Motility, Concentration, Vitality, and Morphology Parameters of Spermatozoa
Authors: Sri Musta'ina  , Eko Budi Siswidiyanto  , Pety Narulita  , Agustinus  , Aucky Hinting  , Atika  , Zakiyatul  Faizah  
Published: October 2024

Highlights:1. Spermatozoa can be affected by coronavirus disease 2019 (COVID-19) due to a disruption in spermatogenesis, leading to a decline in semen quality.2. This study compared the semen quality of COVID-19 survivors and those who had not been infected with COVID-19, specifically on the first spermatogenesis cycle following the confirmation of COVID-19 infection.3. This study is distinctive since no previous research in Indonesia has examined the semen quality parameters, such as the concentration, morphology, motility, and vitality of spermatozoa, in men who had a COVID-19 infection.

Abstract
Semen quality in COVID-19 patients shows inconsistencies and variations. This research was conducted considering that health is the main capital for humans in Indonesia's development, as outlined in Sustainable Development Goal 3. The purpose of this study was to compare the semen quality of COVID-19 survivors with non-COVID-19 men. This study was an analytical observational study with a cross-sectional design. Subjects were selected through consecutive sampling of up to 26 men of childbearing age who met the predetermined criteria. Semen quality assessment using the WHO Semen Analysis Guide 6th edition. Quantitative data were analyzed using SPSS. The data normality test was carried out using the Saphiro-Wilk test. Then, the data were tested by t-test from two unpaired samples and by the Mann-Whitney test. Data from semen analysis based on COVID-19 severity were tested using variant analysis (One-way ANOVA) and the Kruskal Wallis test. The normal morphology of spermatozoa in COVID-19 survivors was significantly lower (p=0.011) compared to uninfected men. Other semen quality parameters did not differ significantly, although they were lower in COVID-19 survivors. The results of the analysis also showed no significant difference in semen parameters related to COVID-19 severity (p=0.488 for progressive motility; p=0.372 for non-progressive motility; p=0.325 for total motility; p=0.707 for immotility; p=0.412 for vitality; p=0.324 for concentration; and p=0.334 for normal morphology). The study provides evidence that COVID-19 survivors have a lower normal spermatozoa morphology compared to uninfected men. However, the motility, vitality, and concentration of spermatozoa did not differ significantly between the two groups.
Larvicidal Effect of Breadfruit (Artocarpus altilis) Flower Extract Against Aedes aegypti
Authors: Ni Wayan Winianti  , Putu Indah Budi Apsari  , Ni Kadek Meta Jayanti  
Published: October 2024

Highlights:1. This study attempted an experiment on the novel invention of a naturally sourced larvacide, specifically breadfruit (Artocarpus atilis) flower extract, against Aedes aegepti.2. The findings of this study suggest that breadfruit flower extract can serve as an effective larvacide, as evident by an increased mortality rate of Aedes aegepti larvae.

Abstract
Dengue hemorrhagic fever remains a major problem in Indonesia. The mosquito that spreads this disease is the Aedes aegypti species. The use of larvicides is a viable method to inhibit the growth of larvae into adult mosquitoes. The flowers of breadfruits (Artocarpus atilis) have long been used as a natural mosquito killer. The objectives of this study were to determine the lethal dose 50 (LC50) of breadfruit flower extract and to analyze its potential as a larvicide against stage 2–3 instar Aedes aegypti larvae. In this true experimental research, each of four treatment groups was administered with breadfruit flower extracts at concentrations of 25, 50, 75, and 90 ppm, respectively. The positive control group was treated with temephos (Abate), while the negative control group received no treatment. Larval mortality was recorded at 1 hour, 2 hours, 3 hours, 4 hours post-intervention. The observed larval deaths were compared among the groups. Quantitative data encompassing the larval mortality in each group were analyzed using the repetitive analysis of variance (ANOVA) and the probit test with minimum p value <0.05. The results indicated that the LC50 value of breadfruit flower extract was 52.67–54.12 ppm. The doses of 50 ppm, 75 ppm and 90 ppm were effective in killing Aedes aegypti larvae. In conclusion, breadfruit flower extract of 50 ppm and higher can effectively kill Aedes aegypti larvae.
Development of electronic students’ worksheets based on problem-based learning on air pollution material
Authors: Destiansari Elvira , Salsabilla Fitri Wahyuni , Meilinda  
Published: October 2024

This research is development research with the aim to produce teaching material products in the form of PBL-based electronic student worksheets on air pollution sub-materials that will be used during the learning process, so that students can be more active and independent. This type of research is development research using the ADDIE model (analysis, design, development, implementation, evaluation), but this research is limited to the development stage. This research was conducted at State Senior High Schools in Palembang in the 2023/2024 school year. The sample in this study was class X students totaling 12 people. Sampling in this study using purposive sampling technique. electronic student worksheets are designed using the Canva and liveworksheets applications; after completing the design of electronic student worksheets, they are assessed by material and media validators using an instrument in the form of a validation questionnaire. After the electronic student worksheet is declared valid, the electronic student worksheet is applied to students in a small group trial. Based on the validation results with the Kappa calculation, the electronic student worksheets were declared valid with a Kappa value of 1. Electronic student worksheets also fall into the very practical category based on the teacher's practicality questionnaire which obtained a percentage of 100%, while the students' practicality questionnaire obtained an average percentage of 90.68%. Based on the results of the validation and practicality questionnaires of teachers and students, it can be concluded that PBL-based electronic student worksheets are valid and feasible to use during the learning process on air pollution sub-materials.
Fourteen-Year-Old Male Football Player with Lesser Tuberosity Avulsion Fracture: Open Transosseous Equivalent Suture Repair
Authors: Puleo James M. , Posner Andrew D. , Kuna Michael C. , Zimmerman Joseph P. 
Published: October 2024

Case:
We report a case of a lesser tuberosity avulsion fracture in a 14-year-old adolescent boy who presented to Orthopaedic Urgent Care where he was promptly diagnosed after magnetic resonance imaging. The patient was successfully treated with an open transosseous equivalent suture repair 3 weeks after initial injury.

Conclusion:
The purpose of this case report was to advance the understanding of these injuries, enable appropriate diagnosis and treatment, and optimize patient's shoulder outcomes and return to sport.
Exploring the lived experiences of menstrual hygiene management among in-school visually impaired adolescent girls in Rwanda: A phenomenological study
Authors: Bazakare Marie Laetitia Ishimwe , Nkurunziza Aimable , Bagirisano Justine , Katende Godfrey , Hitayezu Jean Bosco Henri , Uwera Yvonne Delphine Nsaba , Mukankusi Juliet , Ntirushwa David , Kaberuka Gerard , Mukamana Donatilla , Habtu Michael 
Published: October 2024

Abstract

Background:In low-income countries, many menstruating persons continue to face numerous challenges regarding menstrual hygiene management (MHM). Visual impairment further compounds the difficulties faced by in-school adolescent girls, but little is known about its consequences in Rwanda.
Objective: To explore the lived experiences of MHM among in-school visually impaired adolescent girls in Rwanda.
Design: Descriptive phenomenology.
Methods: This study was conducted in four specialized educational institutions for visually impaired students in Rwanda. We conducted four focus group discussions with 25 visually impaired adolescent girls selected purposively. The seven steps Colaizzi's method were used to analyze the data.
Results: Some participants reported double stigma due to both gender norms and menstruation as well as being visually impaired. Due to taboos and misconceptions around menstruation, some participants reported not getting accurate information about MHM from their parents or teachers. Some poor practices related to taboos and misconceptions such as drying the reusable clothes out of sight of others were reported. Finally, some participants faced a double burden regarding period poverty. Due to the lack of sanitary pads, some must use reusable clothes, which are challenging to clean and dry. In case of water outages, participantscould not travel to fetch water. Educational materials in three out of four girls' rooms are visual, making it difficult for visuallyimpaired girls to access accurate information.
Conclusions: To combat stigma against visually impaired girls who menstruate, it's vital to consider cultural and social contexts. Providing accessible menstrual health management (MHM) education, such as in braille or audio, and ensuring sanitary pad availability is essential. Accessible water stations with tanks should also be constructed to ensure a continuous water supply.
Evaluation of anion exchange resin for sorption of selenium (IV) from aqueous solutions
Authors: El-Tantawy A. , Elgoud E. M. Abu , El-Deen S. E. A. Sharaf 
Published: October 2024

Abstract

In this work, selenium (IV) was adsorbed from aqueous solutions by the strongly basic anion exchange resin Amberlite IRA 400. Using energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM), the morphology of the resin was investigated both before and after Se(IV) sorption. In order to determine the ideal sorption conditions, a batch approach was used to examine the variables that affect the performance of Se(VI) sorption, including pH, shaking time, adsorbate dosage, starting metal ion concentrations and temperature. The sorption process was satisfactorily explained by the pseudo-second-order kinetic model, according to the experimental findings. The maximum adsorption capacity at pH 3.0 was found to be 18.52 mg/g, and the adsorption rather well followed the Langmuir adsorption isotherm. Moreover, exothermic and spontaneous sorption was the result of the thermodynamic properties (negativity of both ΔG° and ΔH°). The adsorption phase's random distribution of the resin-solution interface is indicated by the positive value of ΔSo
N2GNet tracks gait performance from subthalamic neural signals in Parkinson’s disease
Authors: Choi Jin Woo , Cui Chuyi , Wilkins Kevin , Bronte-Stewart Helen 
Published: October 2024

Abstract

Adaptive deep brain stimulation (DBS) provides individualized therapy for people with Parkinson's disease (PWP) by adjusting the stimulation in real-time using neural signals that reflect their motor state. Current algorithms, however, utilize condensed and manually selected neural features which may result in a less robust and biased therapy. In this study, we propose Neural-to-Gait Neural network (N2GNet), a novel deep learning-based regression model capable of tracking real-time gait performance from subthalamic nucleus local field potentials (STN LFPs). The LFP data were acquired when eighteen PWP performed stepping in place, and the ground reaction forces were measured to track their weight shifts representing gait performance. By exhibiting a stronger correlation with weight shifts compared to the higher-correlation beta power from the two leads and outperforming other evaluated model designs, N2GNet effectively leverages a comprehensive frequency band, not limited to the beta range, to track gait performance solely from STN LFPs.
Molecular Identification and Characterization of Bacteria Exhibiting Resistance to Different Metal isolated from Industrial Effluents, CETP, and Sirsa River, Baddi, Himachal Pradesh, India
Authors: Gangta Varsha , Sharma Mamta Devi , Kumari Chandresh , Kumar Pradeep , Kulshrestha Saurabh 
Published: October 2024

Abstract

The rapid industrialization of geologic and human activities has led to the emergence and widespread problem of heavy metal pollution, which poses a considerable menace to both the ecological system and human well-being. The objective of this study is to investigate, extract, recognize, and describe bacteria that possess the ability to reduce and detoxify heavy metals like Cu, Zn, Cd, Ni, Pb, Hg, and Cr found in industrial effluent, CETP, and the Sirsa River. Initially, a combined sum of 100 isolates underwent screening on NA plates containing different heavy metal supplements Pb, Cu, Zn, Cd, Hg, and Cr at a concentration of 50 ppm in their salt form. After screening, the five best isolates that showed high resistance were selected. The MIC of the microbial strains for metallic elements ranged from 50 to 550 ppm. All five isolates with resistance exhibited numerous tolerance to heavy metals and exhibited varying MICs against the aforementioned metallic elements at diverse concentrations. Maximum tolerable concentration and multi-metal resistance were determined. Identification of isolates extended up to the genus level through assessment of their morphological and biochemical characteristics, & analysis of the 16S rRNA gene sequences and were recognized as belonging to the Bacillus cereus (OR243903), Stenotrophomonas maltophila (OR243725), Bacillus cereus (OR244395), Bacillus cereus (OR243740) and E. Coli (OR244383). The bacteria resistant to heavy metals obtained from this research could prove valuable for bioremediation efforts in environments contaminated with heavy metals. Bioremediation, utilizing these bacteria resistant to heavy metals (HMRB), is the most favorable approach to tackle this concern. Therefore, identifying five bacteria for their resistance to heavy metals and capacity for biodegradation serves as a foundational investigation toward developing potential local bioremediation agents for industrial effluent treatment technology.
Single-cell RNA-seq provides insight into the underdeveloped immune system of germ-free mice
Authors: Sheng Yifei , Cheng Wei , Zhang Yin , Liao Qijun , Shen Juan , Zhao Ruizhen , Chai Tailiang , Wu Chao , Hu Weining , Huang Xiang , Wei Bo , Pan Shanshan , Zhang Yangrui , Chen Rouxi , Mei Junpu , Wei Hong , Han Lijuan , Fang Xiaodong 
Published: October 2024

Abstract

Background
Germ-free mice feature a profoundly underdeveloped immune system. Despite recent studies that emphasize the role of specific bacteria-derived metabolites in immune cell development and differentiation, it remains unclear how the lack of microbiota leads to immune deficiencies.
Results
Here we performed droplet-based single-cell RNA sequencing to analyze the bone marrow and peripheral blood of both germ-free and specific-pathogen-free mice, identifying 25 distinct cell types. Our findings indicate that neutrophil apoptosis in germ-free mice is strongly associated with the absence of niacin dehydrogenase, which derived primarily from Pseudomonas. In addition, germ-free mice exhibited elevated excretion of 5’-methylthioadenosine, increased ERK activation induced by reactive oxygen species, and cessation of the bone marrow stromal antigen 2 signaling pathway in germ-free mice. The responses of monocytes and CD8 + T cells to interferon β and interferon γ were reduced in germ-free mice, which accounted for their increased susceptibility to viruses.
Conclusions
Together, we identified a regulatory mechanism connecting immunodeficiency to the absence of microbiota in germ-free mice and validated these findings via multiple techniques.
Design and techno-economic analysis of a 15 kWp grid-tied net-metering solar photovoltaic power plant utilizing half-cut monocrystalline-PERC Si modules with elevated rooftop structure
Authors: Singh Shravan Kumar , Sinha Abhishek , Chander Nikhil 
Published: October 2024

Abstract

The declining cost of photovoltaic (PV) power generation makes on-grid PV plants suitable for residential and commercial applications. The elevated rooftop PV plant installation is an example of a solar plant that generates electricity without disturbing the terrace area. The paper presents the techno-economic analysis of a 15 kWp on-grid power plant placed on the rooftop of Vardhman Hospital with a net-metering scheme located at Durg, Chhattisgarh, India (21°11' N, 81°17' E). The plant rests on an elevated galvanized iron (GI) structure, using half-cut monocrystalline-passivated emitter and rear contact (PERC) cell-based PV modules. The plant's performance parameter and the system losses were calculated using PVsyst simulation software using PVGIS meteorological data. The annual plane of array (POA) irradiation is approximately 2230 kWh/m² at the plant location. The PV energy generation of the plant is 27727 kWh/year, and 27271 kWh/year of energy is injected into the grid. The annual performance ratio of the plant is 81.7%. The research article also focuses on plant design, electricity consumption, and the net electricity bill of the premises for three consecutive years before and after plant installation. The installation of the plant will be equivalent to planting 738 Teak trees over the lifetime, and carbon dioxide emissions mitigated is 461 tonnes. The payback period for an elevated structured on-grid PV plant is around six years.
Insights into the use of cytochrome bc1 inhibitors for future therapeutic strategies for tuberculosis
Authors: Pérez Clara Aguilar , Lenaerts Anne , Villellas Cristina , Guillemont Jerome , Dallow John , Painter Hannah , Ammerman Nicole , Hassan Anis , Golovkine Guillaume , Brock Laure , Chauffour Aurelie , Aubry Alexandra , Mai Thi , Wong Sarah , Clark Taane , Nam Kiyean , Kim Jeongjun , Choi Jinho , Crabbe Marjolein , Esqui Jorge , Lounis Nacer , Stoops Bart , Amssoms Katie , Bartolome-Nebreda Jose , Gruppo Veronica , Robertson Gregory , Veziris Nicolas , Upton Anna , Nuermberger Eric , Cox Vivian , Ballell Lluis , Baeten Benny , Koul Anil , Pym Alexander , Wall Richard , Lamprecht Dirk 
Published: October 2024

Abstract

Recent efforts to improve tuberculosis (TB) treatment options have focused on developing molecules with novel mechanisms of action and identifying optimal treatment regimens. Inhibition of Mycobacterium tuberculosis cytochrome bc1 oxidase has emerged as a promising therapeutic target that could potentially contribute to improved TB combination regimens. Using a relapsing mouse model, we demonstrate that cytochrome bc1 inhibitors could serve as effective partner drugs, enhancing regimen sterilisation. We propose several novel regimen strategies for both multidrug-resistant TB (MDR-TB) and drug-sensitive TB (DS-TB), where cytochrome bc1 inhibitors contribute to sterilisation and treatment shortening. Additionally, we show that clinical isolates exhibit heightened susceptibility to cytochrome bc1 inhibitors compared to laboratory-adapted strains, further supporting their translational potential. These findings suggest that cytochrome bc1 inhibitors have significant potential to improve TB treatment outcomes and highlight the need for further studies to evaluate their clinical contribution to novel treatment regimens.
Median Based Unit Weibull (MBUW): A New Unit Distribution Properties with Real Data Analysis
Authors: Attia Iman Mohammed 
Published: October 2024

Abstract

A new 2 parameter unit Weibull distribution is defined on the unit interval (0,1). The methodology of deducing its PDF, some of its properties and related functions are discussed. The paper is supplied by many figures illustrating the new distribution and how this can make it illegible to fit a wide range of skewed real data.
Determination of activity levels and radiological health risks associated with the consumption of sugar from South Africa
Authors: JOHN Samuel Odumu Ogana , OLUKOTUN Stephen Friday , RADEBE Moses Mpofana , MATHUTHU Manny 
Published: October 2024

Abstract

The study investigates activity levels of 238U, 232Th, and 40K, in fourteen commonly available sugar brands in South Africa, by gamma spectrometry. The findings revealed mean activity levels of 238U, 232Th, and 40K as 3.831 ± 0.208, 2.901 ± 0.208, and 320.257 ± 7.406 Bq/kg, respectively. The mean ingestion dose is 0.730, 0.116 and 0.039 mSv/y for infants (1-2 years), children (7-12 years) and adults (> 17 years), respectively, while 5.038 × 10-4 and 0.128 mSv/y are respective means of ELCR and AGED. The results were found to be below international permissible limits, indicating that the sugar in South Africa is safe and would not pose significant radiological health risks.