bluuebunny/crossref_metadata_2025_split huggingface dataset:
Express assessment of neurotoxicity of particles of planetary and interstellar dust
Authors: Borisova Tatiana 
Published: February 2019

AbstractEstablishment of high-quality, consistent on-board assessment of the neurotoxicity of planetary, and interstellar dust particles will be required to predict their potential threat to human health during long-term space missions. This Perspective article proposes an approach for the rapid assessment of potential neurotoxicity of micro-sized and nano-sized dust particles based on experimental results with other neurotoxic particles. Capacity of particles to affect membrane potential, integrity of nerve terminals, and consequently key synaptic transmission characteristics can be assessed using a planar lipid bilayer technique by monitoring artificial membrane conductivity in the presence of particles. Preliminary neurotoxicity data of nanoparticles, including lunar and Martian dust simulants, obtained using a planar lipid bilayer technique, is compared with that acquired using more-established methodological approaches. Under space flight conditions, neurotoxicity assessments of particulate matter could be rapidly and reproducibly performed using a planar lipid bilayer technique, which does not require biological material.
Multi-qubit Quantum Rabi Model and Multi-partite Entangled States in a Circuit QED System
Authors: Li Jialun , Wang Gangcheng , Xiao Ruoqi , Sun Chunfang , Wu Chunfeng , Xue Kang 
Published: February 2019

AbstractMulti-qubit quantum Rabi model, which is a fundamental model describing light-matter interaction, plays an important role in various physical systems. In this paper, we propose a theoretical method to simulate multi-qubit quantum Rabi model in a circuit quantum electrodynamics system. By means of external transversal and longitudinal driving fields, an effective Hamiltonian describing the multi-qubit quantum Rabi model is derived. The effective frequency of the resonator and the effective splitting of the qubits depend on the external driving fields. By adjusting the frequencies and the amplitudes of the driving fields, the stronger coupling regimes could be reached. The numerical simulation shows that our proposal works well in a wide range of parameter space. Moreover, our scheme can be utilized to generate two-qubit gate, Schrödinger states, and multi-qubit GHZ states. The maximum displacement of the Schrödinger cat states can be enhanced by increasing the number of the qubits and the relative coupling strength. It should be mention that we can obtain high fidelity Schrödinger cat states and multi-qubit GHZ states even the system suffering dissipation. The presented proposal may open a way to study the stronger coupling regimes whose coupling strength is far away from ultrastrong coupling regimes.
The pleasantness of sensory dissonance is mediated by musical style and expertise
Authors: Popescu Tudor , Neuser Monja P. , Neuwirth Markus , Bravo Fernando , Mende Wolfgang , Boneh Oren , Moss Fabian C. , Rohrmeier Martin 
Published: January 2019

AbstractWestern musical styles use a large variety of chords and vertical sonorities. Based on objective acoustical properties, chords can be situated on a dissonant-consonant continuum. While this might to some extent converge with the unpleasant-pleasant continuum, subjective liking might diverge for various chord forms from music across different styles. Our study aimed to investigate how well appraisals of the roughness and pleasantness dimensions of isolated chords taken from real-world music are predicted by Parncutt’s established model of sensory dissonance. Furthermore, we related these subjective ratings to style of origin and acoustical features of the chords as well as musical sophistication of the raters. Ratings were obtained for chords deemed representative of the harmonic language of three different musical styles (classical, jazz and avant-garde music), plus randomly generated chords. Results indicate that pleasantness and roughness ratings were, on average, mirror opposites; however, their relative distribution differed greatly across styles, reflecting different underlying aesthetic ideals. Parncutt’s model only weakly predicted ratings for all but Classical chords, suggesting that listeners’ appraisal of the dissonance and pleasantness of chords bears not only on stimulus-side but also on listener-side factors. Indeed, we found that levels of musical sophistication negatively predicted listeners’ tendency to rate the consonance and pleasantness of any one chord as coupled measures, suggesting that musical education and expertise may serve to individuate how these musical dimensions are apprehended.
Serum GP73 - An Additional Biochemical Marker for Liver Inflammation in Chronic HBV Infected Patients with Normal or Slightly Raised ALT
Authors: Wei Meijuan , Xu Zhengju , Pan Xingnan , Zhang Xiaoman , Liu LiGuan , Yang Bishuang , Chen Yuxia 
Published: February 2019

AbstractThis study aimed to assess the feasibility of GP73 as a diagnostic marker for liver inflammation and fibrosis in chronic HBV patients with normal or slightly raised ALT (<2 ULN) and to develop models based on GP73 and other biochemical parameters to improve diagnostic accuracy. Serum GP73 levels were analyzed in 220 chronic HBV patients with normal or slightly raised ALT who underwent liver biopsy. The results showed that the area under the receiver operating characteristic (ROC) curve (AUC) was 0.806 for predicting significant liver inflammation (≥G2), while it was 0.742 for predicting significant fibrosis (≥S2). These results suggest that GP73 has higher diagnostic value for liver inflammation than liver fibrosis. Combining GP73, AST and ALB, as a diagnostic model for predicting significant liver inflammation, resulted in superior diagnostic performance over GP73 alone (AUC value increased from 0.806 to 0.854, z = 2.299, P = 0.021). By applying this diagnostic model, over 80% of chronic HBV patients with normal or slightly raised ALT will be correctly identified and hence avoid delay in diagnosis and treatment. In conclusion, GP73 would be an additional serum marker for predicting liver inflammation and fibrosis in chronic HBV patients with normal or slightly raised ALT.
Insights into the role of CuO in the CO2 photoreduction process
Authors: Nogueira André E. , Oliveira Jéssica A. , da Silva Gelson T. S. T. , Ribeiro Caue 
Published: February 2019

AbstractThe CO2 photoreduction process to produce light hydrocarbons is known to be influenced by the presence of CuO nanoparticles, but the actual role of this material, whether as a catalyst or a reactant, has not yet been revealed. In this work, we investigate the role of CuO nanoparticles produced by a solvothermal method as a catalyst in CO2-saturated water reaction media under UV light, considering the effects of different electrolytes (Na2C2O4, KBrO3, and NaOH) and temperatures on nanoparticle phase and activity. The electrolyte strongly influenced product selectivity (NaOH led to evolution of CH4, Na2C2O4 to CO, and KBrO3 to O2) and induced CuO phase change. A long-term analysis of these processes indicated that during the initial steps, CuO acted as a reactant, rather than as a catalyst, and was converted to CuCO3.Cu(OH)2, while the as-converted material acted as a catalyst in CO2 photoreduction, with conversion values comparable to those reported in the literature.
Proposed mechanism for the length dependence of the force developed in maximally activated muscles
Authors: Marcucci Lorenzo , Washio Takumi , Yanagida Toshio 
Published: February 2019

AbstractThe molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the length dependent activation (LDA), are largely unknown. However, the recent discovery of the thick filament activation, a second pathway beside the well-known calcium mediated thin filament activation, is promising for elucidating these mechanisms. The thick filament activation is mediated by the tension acting on it through the mechano-sensing (MS) mechanism and can be related to the LDA via the titin passive tension. Here, we propose a mechanism to explain the higher maximum tension at longer sarcomere lengths generated by a maximally activated muscle and test it in-silico with a single fiber and a ventricle model. The active tension distribution along the thick filament generates a reservoir of inactive motors at its free-end that can be activated by passive tension on a beat-to-beat timescale. The proposed mechanism is able to quantitatively account for the observed increment in tension at the fiber level, however, the ventricle model suggests that this component of the LDA is not crucial in physiological conditions.
Consistent Reanalysis of Genome-wide Imprinting Studies in Plants Using Generalized Linear Models Increases Concordance across Datasets
Authors: Wyder Stefan , Raissig Michael T. , Grossniklaus Ueli 
Published: February 2019

AbstractGenomic imprinting leads to different expression levels of maternally and paternally derived alleles. Over the last years, major progress has been made in identifying novel imprinted candidate genes in plants, owing to affordable next-generation sequencing technologies. However, reports on sequencing the transcriptome of hybrid F1 seed tissues strongly disagree about how many and which genes are imprinted. This raises questions about the relative impact of biological, environmental, technical, and analytic differences or biases. Here, we adopt a statistical approach, frequently used in RNA-seq data analysis, which properly models count overdispersion and considers replicate information of reciprocal crosses. We show that our statistical pipeline outperforms other methods in identifying imprinted genes in simulated and real data. Accordingly, reanalysis of genome-wide imprinting studies inArabidopsisand maize shows that, at least forArabidopsis, an increased agreement across datasets could be observed. For maize, however, consistent reanalysis did not yield a larger overlap between the datasets. This suggests that the discrepancy across publications might be partially due to different analysis pipelines but that technical, biological, and environmental factors underlie much of the discrepancy between datasets. Finally, we show that the set of genes that can be characterized regarding allelic bias by all studies with minimal confidence is small (~8,000/27,416 genes forArabidopsisand ~12,000/39,469 for maize). In conclusion, we propose to use biologically replicated reciprocal crosses, high sequence coverage, and a generalized linear model approach to identify differentially expressed alleles in developing seeds.
Seawater temperature and buffering capacity modulate coral calcifying pH
Authors: Guo Weifu 
Published: February 2019

AbstractScleractinian corals promote the precipitation of their carbonate skeleton by elevating the pH and dissolved inorganic carbon (DIC) concentration of their calcifying fluid above that of seawater. The fact corals actively regulate their calcifying fluid chemistry implies the potential for acclimation to ocean acidification. However, the extent to which corals can adjust their regulation mechanism in the face of decreasing ocean pH has not been rigorously tested. Here I present a numerical model simulating pH and DIC up-regulation by corals, and use it to determine the relative importance of physiological regulation versus seawater conditions in controlling coral calcifying fluid chemistry. I show that external seawater temperature and buffering capacity exert the first-order control on the extent of pH elevation in the calcifying fluid and explain most of the observed inter- and intra-species variability. Conversely, physiological regulation, represented by the interplay between enzymatic proton pumping, carbon influx and the exchange of calcifying fluid with external seawater, contributes to some variability but remain relatively constant as seawater conditions change. The model quantitatively reproduces variations of calcifying fluid pH in natural Porites colonies, and predicts an average 0.16 unit decrease in Porites calcifying fluid pH, i.e., ~43% increase in H+ concentration, by the end of this century as a combined result of projected ocean warming and acidification, highlighting the susceptibility of coral calcification to future changes in ocean conditions. In addition, my findings support the development of coral-based seawater pH proxies, but suggest the influences of physicochemical and biological factors other than seawater pH must be considered.
Monolithically integrated white light LEDs on (11–22) semi-polar GaN templates
Authors: Poyiatzis N. , Athanasiou M. , Bai J. , Gong Y. , Wang T. 
Published: February 2019

AbstractCarrier transport issues in a (11–22) semi-polar GaN based white light emitting diode (consisting of yellow and blue emissions) have been investigated by detailed simulations, demonstrating that the growth order of yellow and blue InGaN quantum wells plays a critically important role in achieving white emission. The growth order needs to be yellow InGaN quantum wells first and then a blue InGaN quantum well after the growth of n-type GaN. The fundamental reason is due to the poor hole concentration distribution across the whole InGaN quantum well region. In order to effectively capture holes in both the yellow InGaN quantum wells and the blue InGaN quantum well, a thin GaN spacer has been introduced prior to the blue InGaN quantum well. The detailed simulations of the band diagram and the hole concentration distribution across the yellow and the blue quantum wells have been conducted, showing that the thin GaN spacer can effectively balance the hole concentration between the yellow and the blue InGaN quantum wells, eventually determining their relative intensity between the yellow and the blue emissions. Based on this simulation, we have demonstrated a monolithically multi-colour LED grown on our high quality semi-polar (11–22) GaN templates.
Atomic structures of self-assembled epitaxially grown GdSi2 nanowires on Si(001) by STM
Authors: Song Sun Kyu , Kim Tae-Hwan , Yeom Han Woong 
Published: February 2019

AbstractSelf-assembled rare-earth (RE) silicide nanowires (NWs) on semiconductor surfaces are considered as good candidates for creating and investigating one-dimensional electron systems because of their exceptionally anisotropic growth behavior and metallic property. While detailed atomic structures are essential to understand electronic properties of these NWs, there have been only few successful observations of atomic structures with microscopy and reliable structure models are lacking. Here, we reinvestigate gadolinium silicide NWs with high resolution scanning tunneling microscopy (STM). We observe several different structures of Gd silicide NWs depending systematically on their widths, which consist of two distinct structural elements along the wires. The structure of a wide wire can be understood from that of a two dimensional silicide. Based on these STM observations, we propose new structure models of Gd silicide NWs.
Interactions within the microbiome alter microbial interactions with host chemical defences and affect disease in a marine holobiont
Authors: Longford Sharon R. , Campbell Alexandra H. , Nielsen Shaun , Case Rebecca J. , Kjelleberg Staffan , Steinberg Peter D. 
Published: February 2019

AbstractOur understanding of diseases has been transformed by the realisation that people are holobionts, comprised of a host and its associated microbiome(s). Disease can also have devastating effects on populations of marine organisms, including dominant habitat formers such as seaweed holobionts. However, we know very little about how interactions between microorganisms within microbiomes - of humans or marine organisms – affect host health and there is no underpinning theoretical framework for exploring this. We applied ecological models of succession to bacterial communities to understand how interactions within a seaweed microbiome affect the host. We observed succession of surface microbiomes on the red seaweed Delisea pulchra in situ, following a disturbance, with communities ‘recovering’ to resemble undisturbed states after only 12 days. Further, if this recovery was perturbed, a bleaching disease previously described for this seaweed developed. Early successional strains of bacteria protected the host from colonisation by a pathogenic, later successional strain. Host chemical defences also prevented disease, such that within-microbiome interactions were most important when the host’s chemical defences were inhibited. This is the first experimental evidence that interactions within microbiomes have important implications for host health and disease in a dominant marine habitat-forming organism.
A PET Radiomics Model to Predict Refractory Mediastinal Hodgkin Lymphoma
Authors: Milgrom Sarah A. , Elhalawani Hesham , Lee Joonsang , Wang Qianghu , Mohamed Abdallah S. R. , Dabaja Bouthaina S. , Pinnix Chelsea C. , Gunther Jillian R. , Court Laurence , Rao Arvind , Fuller Clifton D. , Akhtari Mani , Aristophanous Michalis , Mawlawi Osama , Chuang Hubert H. , Sulman Erik P. , Lee Hun J. , Hagemeister Frederick B. , Oki Yasuhiro , Fanale Michelle , Smith Grace L. 
Published: February 2019

AbstractFirst-order radiomic features, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), are associated with disease progression in early-stage classical Hodgkin lymphoma (HL). We hypothesized that a model incorporating first- and second-order radiomic features would more accurately predict outcome than MTV or TLG alone. We assessed whether radiomic features extracted from baseline PET scans predicted relapsed or refractory disease status in a cohort of 251 patients with stage I-II HL who were managed at a tertiary cancer center. Models were developed and tested using a machine-learning algorithm. Features extracted from mediastinal sites were highly predictive of primary refractory disease. A model incorporating 5 of the most predictive features had an area under the curve (AUC) of 95.2% and total error rate of 1.8%. By comparison, the AUC was 78% for both MTV and TLG and was 65% for maximum standardize uptake value (SUVmax). Furthermore, among the patients with refractory mediastinal disease, our model distinguished those who were successfully salvaged from those who ultimately died of HL. We conclude that our PET radiomic model may improve upfront stratification of early-stage HL patients with mediastinal disease and thus contribute to risk-adapted, individualized management.
Behavioral correlates of activity of optogenetically identified locus coeruleus noradrenergic neurons in rats performing T-maze tasks
Authors: Xiang Liyang , Harel Antoine , Gao HongYing , Pickering Anthony E. , Sara Susan J. , Wiener Sidney I. 
Published: February 2019

AbstractThe nucleusLocus Coeruleus (LC) is the major source of forebrain norepinephrine. LC is implicated in arousal, response to novelty, and cognitive functions, including decision-making and behavioral flexibility. One hypothesis is that LC activation promotes rapid shifts in cortical attentional networks following changes in environmental contingencies. Recent recordings further suggest LC is critical for mobilizing resources to deal with challenging situations. In the present study optogenetically identified LC neuronal activity was recorded in rats in a self-paced T-maze. Rats were trained on visual discrimination; then place-reward contingencies were instated. In the session where the animal shifted tasks the first time, the LC firing rate after visual cue onset increased significantly, even as the animal adhered to the previous rule. Firing rate also increased prior to crossing photodetectors that controlled stimulus onset and offset, and this was positively correlated with accelerations, consistent with a role in mobilizing effort. The results contribute to the growing evidence that the noradrenergic LC is essential for behavioral adaptation by promoting cognitive flexibility and mobilizing effort in face of changing environmental contingencies.
Detection of lost calamus challenges identity of isolated Archaeopteryx feather
Authors: Kaye Thomas G. , Pittman Michael , Mayr Gerald , Schwarz Daniela , Xu Xing 
Published: February 2019

AbstractIn 1862, a fossil feather from the Solnhofen quarries was described as the holotype of the iconic Archaeopteryx lithographica. The isolated feather’s identification has been problematic, and the fossil was considered either a primary, secondary or, most recently, a primary covert. The specimen is surrounded by the ‘mystery of the missing quill’. The calamus described in the original paper is unseen today, even under x-ray fluorescence and UV imaging, challenging its original existence. We answer this question using Laser-Stimulated Fluorescence (LSF) through the recovery of the geochemical halo from the original calamus matching the published description. Our study therefore shows that new techniques applied to well-studied iconic fossils can still provide valuable insights. The morphology of the complete feather excludes it as a primary, secondary or tail feather of Archaeopteryx. However, it could be a covert or a contour feather, especially since the latter are not well known in Archaeopteryx. The possibility remains that it stems from a different feathered dinosaur that lived in the Solnhofen Archipelago. The most recent analysis of the isolated feather considers it to be a primary covert. If this is the case, it lacks a distinct s-shaped centerline found in modern primary coverts that appears to be documented here for the first time.
Effects of a hypomagnetic field on DNA methylation during the differentiation of embryonic stem cells
Authors: Baek Soonbong , Choi Hwan , Park Hanseul , Cho Byunguk , Kim Siyoung , Kim Jongpil 
Published: February 2019

AbstractIt has been reported that hypomagnetic fields (HMFs) have a negative influence on mammalian physiological functions. We previously reported that HMFs were detrimental to cell fate changes during reprogramming into pluripotency. These studies led us to investigate whether HMFs affect cell fate determination during direct differentiation. Here, we found that an HMF environment attenuates differentiation capacity and is detrimental to cell fate changes during the in vitro differentiation of embryonic stem cells (ESCs). Moreover, HMF conditions cause abnormal DNA methylation through the dysregulation of DNA methyltransferase3b (Dnmt3b) expression, eventually resulting in incomplete DNA methylation during differentiation. Taken together, these results suggest that an appropriate electromagnetic field (EMF) environment may be essential for favorable epigenetic remodeling during cell fate determination via differentiation.