bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Friends-and-Neighbors” Mobilization: A Field Experimental Replication and Extension
Authors: Panagopoulos Costas , Bailey Kendall 
Published: February 2019

AbstractKey [1949. Southern Politics in State and Nation. New York: A.A. Knopf] observed voters tend to support local candidates at higher rates, a phenomenon he termed “friends-and-neighbors” voting. In a recent study, Panagopoulos et al. [2017. Political Behavior 39(4): 865–82] deployed a nonpartisan randomized field experiment to show that voters in the September 2014 primary election for state senate in Massachusetts were mobilized on the basis of shared geography. County ties and, to a lesser extent, hometown ties between voters and candidates have the capacity to drive voters to the polls. We partnered with a national party organization to conduct a similar, partisan experiment in the November 2014 general election for the Pennsylvania state senate. We find localism cues can stimulate voting in elections, including in neighboring communities that lie beyond the towns and counties in which the target candidate resided, at least among voters favorably disposed to a candidate and even when voters reside in the home county of the opponent.
Association Between Bat Vitamin D Receptor 3′ Haplotypes and Vitamin D Levels at Baseline and a Lower Response After Increased Vitamin D Supplementation and Exposure to Sunlight
Authors: Pérez-Alonso María , Briongos Laisa-Socorro , Ruiz-Mambrilla Marta , Velasco Eladio A. , Olmos José M. , de Luis Daniel , Dueñas-Laita Antonio , Pérez-Castrillón José-Luis 
Published: February 2019

Abstract. Objective: The aim of this study was to evaluate the relationship between vitamin D levels at baseline and after 12 weeks of supplementation/exposure to sunlight and VDR genotypes (BsmI, TaqI and ApaI) and haplotypes in a homogeneous population of postmenopausal women. Methods: We made a prospective study in which 151 women were randomized to two groups: One with 1000 mg of calcium and 800 IU vitamin D supplementation (102 women) and a placebo group with neither calcium or vitamin D supplementation (49 women). The follow-up was from May to September 2012.Vitamin D was determined by chemiluminescent immunoassay. Genotypes were determined using the Sequenomi Plexplatform and haplotypes using PHASE software. Results: Baseline (25 ± 10 ng/ml vs.23 ± 9 ng/ml, p > 0.05) and 12-week (32 ± 8 ng/ml vs.29 ± 10 ng/ml, p > 0.05) vitamin D levels were similar between the two groups. The genetic study was made in the total population. There were no differences in baseline and final levels of vitamin D in terms of genotypes and haplotypes, except for the Bat haplotype, whose baseline values were lower (25OHD: 21 ± 10 ng/ml vs. 21 ± 10 ng/ml, p = 0.038). The rate of nonresponders in this group was 15 % (p = 0.001), compared with 9 %, 2 % and 3 % in the other groups. Conclusions: The Bat haplotype was associated with lower baseline levels of vitamin D and a worse response to supplementation and, therefore, may be a risk factor for vitamin D deficiency.
Relationship between vitamin D level and Bechcet’s disease activity: A systematic review and meta-analysis
Authors: Khabbazi Alireza , Ghojazadeh Morteza , Hajebrahimi Sakineh , Nikniaz Zeinab 
Published: February 2019

Abstract. Aim: In the present study, the evidence about the association between vitamin D deficiency and Behcet’s disease activity was systematically reviewed and meta-analyzed. Method: We searched the English and Persian databases of Medline (Ovid), CINHAL, Scopus, Proquest, the Cochrane library and SID, IranDoc, Magiran, Iran Medex for articles published up until May 2018 with the keywords were related to serum vitamin D and active and inactive Behcet’s disease in adults. Meta-analysis was done using the CMA software. Results: A total of 138 titles were retrieved and reduced to 80 titles after deletion of duplicates and finally after close assessing of titles and abstracts eight eligible studies including a total of 939 participants were identified for systematic review and meta-analysis. According to the results of the meta-analysis, the pooled effect size of the differences in the serum level of vitamin D in patients with inactive Behçet’s Disease and healthy controls was [OR:−0.05; 95% CI:−2.05, 1.94; p = 0.95]. The serum vitamin D level was significantly lower in active patients compared with healthy controls [OR:1.21; 95%CI: −0.12, 2.31; p = 0.03]. The pooled effect size of the differences in the serum level of vitamin D in active and inactive Behçet’s Disease was [OR:−0.71; 95%CI: −1.41, −0.007; p = 0.04] Conclusion: There is an association between vitamin D deficiency and active Behçet’s Disease. Future studies investigating the association of vitamin D deficiency and Behçet’s Disease needs to involve following information: dietary intake of calcium and vitamin D, measuring of sun exposure, report of drug consumption and physical activity level.
The Impact of Strong El Niño and La Niña Events on the North Atlantic
Authors: Hardiman S. C. , Dunstone N. J. , Scaife A. A. , Smith D. M. , Ineson S. , Lim J. , Fereday D. 
Published: February 2019

AbstractThe impact of strong La Niña events on January–February North Atlantic mean sea level pressure is unknown, as these events have never been observed. Using large ensembles from the Met Office decadal prediction system, examples of strong La Niña events are simulated and the Atlantic response to these is found to be a positive North Atlantic Oscillation. This is very different to the wavelike response observed and simulated for strong El Niño events. The reason for this difference is traced to the fact that the December‐January‐February mean tropospheric teleconnection of El Niño–Southern Oscillation to the North Atlantic dominates for strong El Niño events, while the stratospheric teleconnection dominates for strong La Niña events. The strength of the tropospheric pathway grows linearly and symmetrically with El Niño–Southern Oscillation. The stratospheric pathway is the source of the asymmetry between January and February surface responses to strong El Niño and strong La Niña events.
Does the Solar Wind Electric Field Control the Reconnection Rate at Earth's Subsolar Magnetopause?
Authors: Dorelli John C. 
Published: February 2019

AbstractWe demonstrate that the reconnection rate at the subsolar magnetopause is strongly controlled by the solar wind electric field and depends weakly on the local properties of the dissipation region. Our approach is to match the solar wind and magnetospheric states in an internal boundary layer described by the Cassak and Shay (2007, https://doi.org/10.1063/1.2795630) expression for two‐dimensional asymmetric reconnection. Faraday's law along the Sun‐Earth line determines the variation of the solar wind electric field from the bow shock to the magnetopause. While the magnetospheric plasma exerts some control over the reconnection rate, magnetic flux pileup in the sheath partially compensates for any local reduction in the reconnection rate. For a fixed magnetospheric state, the reconnection rate is shown to be directly proportional to the solar wind electric field, thus explaining why the solar wind electric field correlates well with geomagnetic indices.
Tectonothermal Evolution of the Broadly Rifted Zone, Ethiopian Rift
Authors: Boone S. C. , Balestrieri M.‐L. , Kohn B. P. , Corti G. , Gleadow A. J. W. , Seiler C. 
Published: February 2019

AbstractThe Broadly Rifted Zone (BRZ) of southern Ethiopia is a long‐lived and structurally complex segment of the East African Rift System. However, due to poor surface exposure of early synrift strata and a dearth of subsurface data, the evolution of the BRZ remains poorly understood. We present new apatite (U‐Th‐Sm)/He and augmented apatite fission track low‐temperature thermochronology data from the Beto and Galana basin boundary fault systems to constrain the tectonothermal evolution of the western and eastern BRZ, respectively. Time‐temperature reconstructions suggest that East African Rift System‐related extension began concurrently across the BRZ in the early Miocene (20–17 Ma), at least 6 Myr prior to faulting in the Main Ethiopian Rift further north. Increased time‐temperature resolution provided by multithermochronometer analyses reveals contrasting along‐strike spatiotemporal variations in Beto and Galana margin cooling histories, which appear to mirror the disparate structural geometries of their basin‐bounding normal fault arrays. Longitudinal contrasts in basin architecture and rift‐related cooling histories across the BRZ may reflect the region's heterogeneous distribution of preexisting basement fabrics, namely, the presence of a previously reported N‐NNE trending Neoproterozoic suture zone beneath the eastern BRZ. Its influence may explain both the development of long, curvilinear faults and the gradual basinward migration of strain exhibited by the easternmost BRZ, absent further west. The anomalous evolution of the BRZ compared to the greater Ethiopian Rift, both in its earlier onset and its wider deformation zone, likely results from its inheritance of preattenuated lithosphere, thermomechanically modified by earlier Cretaceous‐Paleogene Anza‐South Sudan rifting and/or Eocene plume impingement.
Late Quaternary Activity of the La Rinconada Fault Zone, San Juan, Argentina
Authors: Rimando Jeremy M. , Schoenbohm Lindsay M. , Costa Carlos H. , Owen Lewis A. , Cesta Jason M. , Richard Andres D. , Gardini Carlos E. 
Published: February 2019

AbstractMost of the permanent deformation in the Pampean Flat slab segment of the central Andes is taken up at the Andean Orogenic Front in Argentina, a narrow zone between the Eastern Precordillera and Sierras Pampeanas that comprises one of the world's most seismically active thrust zones. Active faults and folds in the region have been extensively mapped but still largely lack information on style and rates of deformation, which is essential for understanding the distribution of regional strain and estimating the seismic potential of individual faults. Structural, geomorphic, and36Cl cosmogenic radionuclide surface exposure age methods are used to focus on key sites along the 30‐km‐long La Rinconada Fault Zone in this region of west‐central Argentina, which is ~15 km away from the highly populated (~500,000) city of San Juan, to define a late Quaternary average shortening rate of 0.41 ± 0.01 mm/year. This slip rate is the same order of magnitude, but slightly lower than nearby similar east dipping Eastern Precordillera faults including the La Laja and Las Tapias Faults. Relatively low slip rates are interpreted as being a consequence of distributed deformation between the latitude of the La Rinconada Fault Zone (31 and 32°S), as compared to between latitudes 32 to 33°S where deformation appears to be focused on fewer structures, including the Las Peñas and La Cal Thrust Faults. The La Rinconada Fault Zone is capable of generating earthquakes ofMw6.6–7.2, but further investigations are required to determine timing and recurrence intervals of discrete events.
Fluid Geochemistry Contribution to the Interpretation of the 2011–2012 Unrest of Santorini, Greece, in the Frame of the Dynamics of the Aegean Volcanic Arc
Authors: Tarchini L. , Carapezza M. L. , Ranaldi M. , Sortino F. , Gattuso A. , Acocella V. 
Published: February 2019

AbstractTectonic and magmatic activity may couple at volcanic arcs, even though any relationship is less defined in smaller arcs, experiencing limited activity. Here we use gas geochemistry data collected during the 2011–2012 unrest at Santorini (Greece) to understand better the dynamics of the Aegean Volcanic Arc with regard to its tectonic setting. Since the most recent eruption in 1950 and before the unrest, minor seismicity and CO2 degassing (mainly from the fumaroles of Nea Kameni islet) were observed at Santorini. On January 2011, anomalous seismicity along the NE‐SW trending Kameni Line was accompanied by an inflation north of Nea Kameni. Fumarolic gas composition changed and gas release notably increased. We carried out geochemical study on both Kameni and Thera islands from January 2012 to June 2013. We repeated surveys of diffuse soil CO2 degassing and of in‐soil gas concentration, and we analyzed fumaroles and gas dissolved in thermal waters for chemical and isotopic composition. In agreement with previous studies, our geochemical data, particularly the diffuse soil CO2 flux increase, the increase of H2 content, and of CO2/CH4 and 3He/4He ratios in fumarolic gases, support geophysical data in indicating that unrest was associated with the emplacement of new mafic magma. This unrest had limited effect on the regional setting, with gas emissions focusing along the regional NE‐SW structures, without triggering by any seismic event, conversely to the 1950 eruption, which probably occurred in a frame of general tectonic reorganization of the Aegean microplate.
Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes
Authors: Maurel Delphine B. , Matsumoto Tsutomu , Vallejo Julian A. , Johnson Mark L. , Dallas Sarah L. , Kitase Yukiko , Brotto Marco , Wacker Michael J. , Harris Marie A. , Harris Stephen E. , Bonewald Lynda F. 
Published: February 2019

AbstractTransgenic mice are widely used to delete or overexpress genes in a cell specific manner to advance knowledge of bone biology, function and disease. While numerous Cre models exist to target gene recombination in osteoblasts and osteoclasts, few target osteocytes specifically, particularly mature osteocytes. Our goal was to create a spatial and temporal conditional Cre model using tamoxifen to induce Cre activity in mature osteocytes using a Bac construct containing the 5’ and 3’ regions of the Sost gene (Sost ERT2 Cre). Four founder lines were crossed with the Ai9 Cre reporter mice. One founder line showed high and specific activity in mature osteocytes. Bones and organs were imaged and fluorescent signal quantitated. While no activity was observed in 2 day old pups, by 2 months of age some osteocytes were positive as osteocyte Cre activity became spontaneous or ‘leaky’ with age. The percentage of positive osteocytes increased following tamoxifen injection, especially in males, with 43% to 95% positive cells compared to 19% to 32% in females. No signal was observed in any bone surface cell, bone marrow, nor in muscle with or without tamoxifen injection. No spontaneous signal was observed in any other organ. However, with tamoxifen injection, a few positive cells were observed in kidney, eye, lung, heart and brain. All other organs, 28 in total, were negative with tamoxifen injection. However, with age, a muscle phenotype was apparent in the Sost-ERT2 Cre mice. Therefore, although this mouse model may be useful for targeting gene deletion or expression to mature osteocytes, the muscle phenotype may restrict the use of this model to specific applications and should be considered when interpreting data.
BCL-2 family isoforms in apoptosis and cancer
Authors: Warren Chloe F. A. , Wong-Brown Michelle W. , Bowden Nikola A. 
Published: February 2019

AbstractThe BCl-2 family has long been identified for its role in apoptosis. Following the initial discovery of BCL-2 in the context of B-cell lymphoma in the 1980s, a number of homologous proteins have since been identified. The members of the Bcl-2 family are designated as such due to their BCL-2 homology (BH) domains and involvement in apoptosis regulation. The BH domains facilitate the family members’ interactions with each other and can indicate pro- or anti-apoptotic function. Traditionally, these proteins are categorised into one of the three subfamilies; anti-apoptotic, BH3-only (pro-apoptotic), and pore-forming or ‘executioner’ (pro-apoptotic) proteins. Each of the BH3-only or anti-apoptotic proteins has a distinct pattern of activation, localisation and response to cell death or survival stimuli. All of these can vary across cell or stress types, or developmental stage, and this can cause the delineation of the roles of BCL-2 family members. Added to this complexity is the presence of relatively uncharacterised isoforms of many of the BCL-2 family members. There is a gap in our knowledge regarding the function of BCL-2 family isoforms. BH domain status is not always predictive or indicative of protein function, and several other important sequences, which can contribute to apoptotic activity have been identified. While therapeutic strategies targeting the BCL-2 family are constantly under development, it is imperative that we understand the molecules, which we are attempting to target. This review, discusses our current knowledge of anti-apoptotic BCL-2 family isoforms. With significant improvements in the potential for splicing therapies, it is important that we begin to understand the distinctions of the BCL-2 family, not limited to just the mechanisms of apoptosis control, but in their roles outside of apoptosis.
Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer
Authors: Yang Jiao , Zhang Xiaoman , Chen Zheling , Shen Yanwei , Wang Fan , Wang Yaochun , Liu Yu , Liu Peijun , Yang Jin 
Published: February 2019

AbstractGrowing evidence indicates that Angiomotin (Amot)-p130 and Amot-p80 have different physiological functions. We hypothesized that Amot-p130 is a tumor suppressor gene in breast cancer, in contrast with the canonical oncogenicity of Amot-p80 or total Amot. To clarify the role of Amot-p130 in breast cancer, we performed real-time quantitative PCR, western blotting, flow cytometry, microarray, immunofluorescence, immunoprecipitation, and tumor sphere-formation assays in vitro, as well as tumorigenesis and limited-dilution analysis in vivo. In this study, we showed that Amot-p130 inhibited the proliferation, migration, and invasion of breast cancer cells. Interestingly, transcriptional profiles indicated that genes differentially expressed in response to Amot-p130 knockdown were mostly related to β-catenin signaling in MCF7 cells. More importantly, most of the downstream partners of β-catenin were associated with stemness. In a further validation, Amot-p130 inhibited the cancer stem cell potential of breast cancer cells both in vitro and in vivo. Mechanistically, Amot-p130 decreased β-catenin stability by competing with Axin for binding to tankyrase, leading to a further inhibition of the WNT pathway. In conclusions, Amot-p130 functions as a tumor suppressor gene in breast cancer, disrupting β-catenin stability by competing with Axin for binding to tankyrase. Amot-p130 was identified as a potential target for WNT pathway-targeted therapies in breast cancer.
Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling
Authors: Breuer Eun-Kyoung , Fukushiro-Lopes Daniela , Dalheim Annika , Burnette Miranda , Zartman Jeremiah , Kaja Simon , Wells Claire , Campo Loredana , Curtis Kimberly J. , Romero-Moreno Ricardo , Littlepage Laurie E. , Niebur Glen L. , Hoskins Kent , Nishimura Michael I. , Gentile Saverio 
Published: February 2019

AbstractPotassium ion channels are critical in the regulation of cell motility. The acquisition of cell motility is an essential parameter of cancer metastasis. However, the role of K+ channels in cancer metastasis has been poorly studied. High expression of the hG1 gene, which encodes for Kv11.1 channel associates with good prognosis in estrogen receptor-negative breast cancer (BC). We evaluated the efficacy of the Kv11.1 activator NS1643 in arresting metastasis in a triple negative breast cancer (TNBC) mouse model. NS1643 significantly reduces the metastatic spread of breast tumors in vivo by inhibiting cell motility, reprogramming epithelial–mesenchymal transition via attenuation of Wnt/β-catenin signaling and suppressing cancer cell stemness. Our findings provide important information regarding the clinical relevance of potassium ion channel expression in breast tumors and the mechanisms by which potassium channel activity can modulate tumor biology. Findings suggest that Kv11.1 activators may represent a novel therapeutic approach for the treatment of metastatic estrogen receptor-negative BC. Ion channels are critical factor for cell motility but little is known about their role in metastasis. Stimulation of the Kv11.1 channel suppress the metastatic phenotype in TNBC. This work could represent a paradigm-shifting approach to reducing mortality by targeting a pathway that is central to the development of metastases.
CXCL5 induces tumor angiogenesis via enhancing the expression of FOXD1 mediated by the AKT/NF-κB pathway in colorectal cancer
Authors: Chen Chun , Xu Zhuo-Qing , Zong Ya-Ping , Ou Bao-Chi , Shen Xiao-Hui , Feng Hao , Zheng Min-Hua , Zhao Jing-Kun , Lu Ai-Guo 
Published: February 2019

AbstractThe mechanisms underlying the role of CXCL5 in tumor angiogenesis have not been fully defined. Here, we examined the effect of CXCL5 on tumor angiogenesis in colorectal cancer (CRC). Immunohistochemistry was used to monitor the expression of CXCL5 and CD31 in CRC patients’ tissues. HUVEC cell lines stably transfected with shCXCR2 and shFOXD1 lentivirus plasmids were used in an in vitro study. Based on some molecular biological experiments in vitro and in vivo, we found that CXCL5 was upregulated in tumor tissues and that its level positively correlated with the expression of CD31. Next, we used recombinant human CXCL5 (rhCXCL5) to stimulate HUVECs and found that their tube formation ability, proliferation, and migration were enhanced by the activation of the AKT/NF-κB/FOXD1/VEGF-A pathway in a CXCR2-dependent manner. However, silencing of CXCR2 and FOXD1 or inhibition of the AKT and NF-κB pathways could attenuate the tube formation ability, proliferation, and migration of rhCXCL5-stimulated HUVECs in vitro. rhCXCL5 can promote angiogenesis in vivo in Matrigel plugs, and the overexpression of CXCL5 can also increase microvessel density in vivo in a subcutaneous xenotransplanted tumor model in nude mice. Taken together, our findings support CXCL5 as an angiogenic factor that can promote cell metastasis through tumor angiogenesis in CRC. Furthermore, we propose that FOXD1 is a novel regulator of VEGF-A. These observations open new avenues for therapeutic application of CXCL5 in tumor anti-angiogenesis.
Polygyny is linked to accelerated birdsong evolution but not to larger song repertoires
Authors: Snyder Kate T. , Creanza Nicole 
Published: February 2019

AbstractNon-monogamous mating behaviors including polygyny or extra-pair paternity are theorized to amplify sexual selection, since some males attract multiple mates or copulate with paired females. In several well-studied songbird species, females prefer more complex songs and larger repertoires; thus, non-monogamous mating behaviors are predicted to accelerate song evolution, particularly toward increased complexity. However, studies within songbird clades have yielded mixed results, and the effect of non-monogamy on song evolution remains unclear. Here, we construct a large-scale database synthesizing mating system, extra-pair paternity, and song information and perform comparative analyses alongside songbird genetic phylogenies. Our results suggest that polygyny drives faster evolution of syllable repertoire size (measured as average number of unique syllables), but this rapid evolution does not produce larger repertoires in polygynous species. Instead, both large and small syllable repertoires quickly evolve toward moderate sizes in polygynous lineages. Contrary to expectation, high rates of extra-pair paternity coincide with smaller repertoires.