bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain-on-a-chip Devices for Drug Screening and Disease Modeling Applications
Authors: Miccoli Beatrice , Braeken Dries , Li Yi-Chen Ethan 
Published: February 2019

:Neurodegenerative disorders are related to the progressive functional loss of the brain, often connected to emotional and physical disability and, ultimately, to death. These disorders, strongly connected to the aging process, are becoming increasingly more relevant due to the increase of life expectancy. Current pharmaceutical treatments poorly tackle these diseases, mainly acting only on their symptomology. One of the main reasons of this is the current drug development process, which is not only expensive and time-consuming but, also, still strongly relies on animal models at the preclinical stage.:Organ-on-a-chip platforms have the potential to strongly impact and improve the drug screening process by recreating in vitro the functionality of human organs. Patient-derived neurons from different regions of the brain can be directly grown and differentiated on a brain-on-a-chip device where the disease development, progression and pharmacological treatments can be studied and monitored in real time. The model reliability is strongly improved by using human-derived cells, more relevant than animal models for pharmacological screening and disease monitoring. The selected cells will be then capable of proliferating and organizing themselves in the in vivo environment thanks to the device architecture, materials selection and bio-chemical functionalization.:In this review, we start by presenting the fundamental strategies adopted for brain-on-a-chip devices fabrication including e.g., photolithography, micromachining and 3D printing technology. Then, we discuss the state-of-theart of brain-on-a-chip platforms including their role in the study of the functional architecture of the brain e.g., blood-brain barrier, or of the most diffuse neurodegenerative diseases like Alzheimer’s and Parkinson’s. At last, the current limitations and future perspectives of this approach for the development of new drugs and neurodegenerative diseases modeling will be discussed.
Expression of NRP-1 and NRP-2 in Endometrial Cancer
Authors: Oplawski Marcin , Dziobek Konrad , Grabarek Beniamin , Zmarzły Nikola , Dąbruś Dariusz , Januszyk Piotr , Brus Ryszard , Tomala Barbara , Boroń Dariusz 
Published: February 2019

Background:Neuropilins (NRPs) participate in many processes related to cancer development such as angiogenesis, lymphangiogenesis and metastasis. Although endometrial cancer is one of the most common gynecological cancers, it has not been studied in terms of NRPs expression.Objective:The aim of this study was to investigate the potential utility of NRPs as important factors in the diagnosis and treatment of endometrial cancer.Methods:Our study consisted of 45 women diagnosed with endometrial cancer at the following degrees of histological differentiation: G1, 17; G2, 15; G3, 13 cases. The control group included 15 women without neoplastic changes. The immunohistochemical reactions were evaluated using light microscopy.Results:We did not detect the expression of NRP-1 and NRP-2 in the control group. NRP-1 expression was found exclusively in cancer cells. It was higher in G2 and G3 and reached about 190% of G1. NRP-2 expression was observed in the endothelium and was similar across all three cancer grades. In cancer cells, NRP-2 expression increased with the degree of histological differentiation.Conclusion:NRP1 and NRP2 are candidates for complementary diagnostic molecular markers and promising new targets for molecular, personalized anticancer therapies.
Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic-related Liver Diseases and Hepatocellular Carcinoma
Authors: Sánchez-Crisóstomo Isabel , Fernández-Martínez Eduardo , Cariño-Cortés Raquel , Betanzos-Cabrera Gabriel , Bobadilla-Lugo Rosa A. 
Published: February 2019

Background:Liver ailments are among the leading causes of death; they originate from viral infections, chronic alcoholism, and autoimmune illnesses, which may chronically be precursors of cirrhosis; furthermore, metabolic syndrome may worsen those hepatopathies or cause Non-alcoholic Fatty Liver Disease (NAFLD) that may advance to non-alcoholic steatohepatitis (NASH). Cirrhosis is the late-stage liver disease and can proceed to hepatocellular carcinoma (HCC). Pharmacological treatment options for liver diseases, cirrhosis, and HCC, are limited, expensive, and not wholly effective. The use of medicinal herbs and functional foods is growing around the world as natural resources of bioactive compounds that would set the basis for the development of new drugs.Review and Conclusion:Plant and food-derived sterols and triterpenoids (TTP) possess antioxidant, metabolic-regulating, immunomodulatory, and anti-inflammatory activities, as well as they are recognized as anticancer agents, suggesting their application strongly as an alternative therapy in some chronic diseases. Thus, it is interesting to review current reports about them as hepatoprotective agents, but also because they structurally resemble cholesterol, sexual hormones, corticosteroids and bile acids due to the presence of the steroid nucleus, so they all can share pharmacological properties through activating nuclear and membrane receptors. Therefore, sterols and TTP appear as a feasible option for the prevention and treatment of chronic metabolic-related liver diseases, cirrhosis, and HCC.
Therapeutic Potential of Melatonin in the Regulation of MiR-148a-3p and Angiogenic Factors in Breast Cancer
Authors: Lacerda Jéssica Zani , Ferreira Lívia Carvalho , Lopes Beatriz Camargo , Aristizábal-Pachón Andrés Felipe , Bajgelman Marcio Chaim , Borin Thaiz Ferraz , de Campos Zuccari Debora Aparecida Pires 
Published: February 2019

Background:The high mortality rate of breast cancer is related to the occurrence of metastasis, a process that is promoted by tumor angiogenesis. MicroRNAs are small molecules of noncoding mRNA that play a key role in gene regulation and are directly involved in the progression and angiogenesis of various tumor types, including breast cancer. Several miRNAs have been described as promoters or suppressors angiogenesis and may be associated with tumor growth and metastasis. Melatonin is an oncostatic agent with a capacity of modifying the expression of innumerable genes and miRNAs related to cancer.Objective:The aim of this study was to evaluate the role of melatonin and the tumor suppressor miR- 148a-3p on angiogenesis of breast cancer.Method:MDA-MB-231 cells were treated with melatonin and modified with the overexpression of miR-148a-3p. The relative quantification in real-time of miR-148a-3p, IGF-IR and VEGF was performed by real-time PCR. The protein expression of these targets was performed by immunocytochemistry and immunohistochemistry. Survival, migration and invasion rates of tumor cells were evaluated. Finally, the xenograft model of breast cancer was performed to confirm the role of melatonin in the tumor.Results:The melatonin was able to increase the gene level of miR-148a-3p and decreased the gene and protein expression of IGF-1R and VEGF, both in vitro and in vivo. In addition, it also had an inhibitory effect on the survival, migration and invasion of breast tumor cells.Conclusion:Our results confirm the role of melatonin in the regulation of miR-148a-3p and decrease of angiogenic factors.
The Effect of Acquirer Net Operating Losses on Acquisition Premiums and Acquirer Abnormal Returns
Authors: Erickson Merle M. , Ton Karen , Wang Shiing-wu 
Published: February 2019

ABSTRACT
This study examines whether acquirer NOL-related tax benefits generated in an acquisition are shared with the target. For a sample of 1,959 acquisitions, we find that acquisitions of profitable targets by acquirers with NOLs are associated with higher acquisition premiums than acquisitions by non-NOL acquirers. This result indicates that potential post-acquisition tax benefits from use of acquirer NOLs are shared with the target in the form of higher transaction prices. We also find that the acquirer's merger announcement stock price response is positively associated with these tax benefits, which is consistent with the conclusion that acquirers retain part of these potential tax benefits.
Perkembangan Desa Wisata Krebet dan Dampaknya Terhadap Kondisi Masyarakat Dusun Krebet, Desa Sendangsari, Kecamatan Pajangan, Kabupaten Bantul
Authors: Rahmawati Rosyida , Purwohandoyo Joni 
Published: February 2019

Desa Wisata Krebet memiliki simbol utama kerajinan batik kayu. Ada dampak ekonomi yang dirasakan masyarakat Dusun Krebet sejak menjadi desa wisata, yaitu dampak langsung, dampak tidak langsung, dampak lanjutan, maupun efek pengganda dari kegiatan wisata. Penelitian ini bertujuan mengidentifikasi perkembangan Desa Wisata Krebet, menganalisis efek pengganda dari adanya perkembangan Desa Wisata Krebet, dan menganalisis keterkaitan antara perkembangan Desa Wisata Krebet dengan dampak ekonomi yang ditimbulkan. Analisis data dilakukan dengan cara analisis deskriptif, analisis dampak ekonomi kegiatan pariwisata, dan analisis efek pengganda. Hasil penelitian menunjukkan bahwa perkembangan Desa Wisata Krebet yang dilihat dari empat aspek perkembangan desa wisata, saling berhubungan dengan dampak ekonomi yang ditimbulkan. Namun, dampak langsung yang berasal dari kegiatan non wisata lebih tinggi dibandingkan dengan dampak langsung yang berasal dari wisatawan. Hal ini menunjukkan bahwa usaha di Desa Wisata Krebet akan tetap berjalan meskipun wisatawan yang berkunjung ke Desa Wisata Krebet mengalami kenaikan atau penurunan jumlah kunjungan karena produk kerajinan batik kayu dapat dipasarkan keluar Desa Wisata Krebet. Adanya branding œDesa Wisata Krebet juga akan membantu pemasaran produk kerajinan batik kayu di luar Desa Wisata Krebet. Kata kunci: Perkembangan Desa Wisata, Dampak Ekonomi, Multiplier Effect. The icon of Krebet Tourism Village is wooden batik craft. There is an economic impact felt by the community of Krebet Hamlet since becoming a tourism village, there are direct impacts, indirect impacts, induced impacts and multiplier effects of tourism activities in Krebet Tourism Village. This research aims to identify the development of the Krebet Tourism Village, analyzing the multiplier effects of the development of the Krebet Tourism Village, and analyzing the linkages between the development of the Krebet Tourism Village and the economic impacts. Data analysis was done by descriptive analysis, analysis of the economic impact of tourism activities, and analysis of multiplier effects. The results of the research indicate that the development of the Krebet Tourism Village which is viewed from four aspects of rural tourism development were related to economic impact. However, the direct impact of non-tourism activities was higher than the direct impact from tourists. This shows that businesses in the Krebet Tourism Village will continue to run even though tourists who visited Krebet Tourism Village either increased or decreased because the wooden batik craft products can be marketed outside Krebet Tourism Village. The branding of "Krebet Tourism Village" will also help the marketing of wooden batik craft products outside Krebet Tourism Village. Keywords: The development of Tourism Village, Economic Impacts, Multiplier Effect.
Effect of vitamin C supplementation on gingival bleeding
Authors: Pribadi Indra Mustika Setia , Rusminah Nunung , Rusyanti Yanti , Suwargiani Anne Agustina 
Published: February 2019

Introduction: Periodontitis is a multifactorial disease caused by a disproportion between environmental factors such as periodontal pathogens and the host defence. Genetic factors, hormones, and nutrition may influence host defence mechanisms. One of the nutrition needed for periodontal health is vitamin C. This study was aimed to evaluate the effect of vitamin C supplementation on gingival bleeding. Methods: As much as ninety-eight patients with chronic periodontitis consisted of 42 males and 56 females, aged 30 – 59-years-old participated in this study. Gingival bleeding was assessed before and after 3 months administered with vitamin C supplementation. Gingival bleeding criteria was based on Van der Velden with tooth selection based on Ramfjörd. Result: Gingival bleeding before the administration of vitamin C supplementation was found in the high category at 4 patients (4.1%), medium at 36 patients (36.7%), and low at 58 patients (59.2%). After 3 months administration of vitamin C supplementation, high category gingival bleeding was found in 2 patients (2%), medium in 16 patients (16.3%), and low in 80 patients (81.6%). Conclusion: There was an effect of vitamin C supplementation on gingival bleeding.Keywords: Chronic periodontitis, vitamin C supplementation, gingival bleeding.
THE QUALITY OF SERVICES (QOS) OF GAMINGANYWHERE ON A GAME WITH SPEECH RECOGNITION SYSTEM AS COMMAND INPUT
Authors: . Sussi . , . Rendy Munadi , . Nurwulan Fitriyanti , Putra Sutejo Indra Perdana 
Published: February 2019

Perkembangan dunia industri game semakin semarak dengan munculnya teknologi jaringan dibidang Cloud Gaming. Platform Cloud Gaming yang sering digunakan dan sifatnya open source yaitu GamingAnywhere. Dengan menggunakan cloud gaming GamingAnywhere dan platform speech recognition system FreeePIE, client dapat memainkan game berspesifikasi tinggi pada perangkat miliknya yang berspesifikasi lebih rendah dengan sistem input menggunakan perintah suara. Pencinta game yang memiliki kerusakan motoris tangan masih bisa menikmati game dengan inputan suara.
Penelitian akan Cloud Gaming yang ada masih terbatas, karena teknologi Cloud Gaming merupakan teknologi yang baru (2013). Penelitian ini ditujukan untuk memberikan informasi mengenai Quality of Service (QoS) dari GamingAnywhere. Dari hasil pengukuran, untuk meraih QoS yang optimal dalam menjalankan game dengan cloud gaming GamingAnywhere, dibutuhkan minimal bandwidth sebesar 3 Mbps. Bila bandwidth yang diberikan kurang dari 3 Mbps, sistem akan mengalami delay yang massif bernilai Â± 0.5 detik pada game NEVERBALL dan bernilai Â± 1.9 detik pada game 7 Days to Die dan packet loss yang dihasilkan pun akan sangat tinggi.
Evaluasi Daftar Stopword Bahasa Indonesia
Authors: Rahutomo Faisal , Ririd Ariadi Retno Tri Hayati 
Published: February 2019

Pada sistem temu kembali informasi berbentuk teks maupun text mining, terdapat proses pengindeksan. Teks diproses dengan tujuan mengintisarikan informasi berbentuk teks tersebut. Salah satu proses yang dilakukan adalah stopword filtering, beberapa kata yang tidak layak diindeks diabaikan berdasar sebuah daftar. Di dalam sistem berbahasa Indonesia, terdapat beberapa versi daftar stopword yang tersedia bebas. Penelitian ini bertujuan mengevaluasi daftar yang telah tersedia tersebut. Tujuan akhir dari penelitian ini adalah telaah daftar yang tersedia berdasarkan tata bahasa Indonesia, cara penyusunan, dan kebiasaan perambah internet. Dari hasil telaah diperoleh fakta bahwa daftar yang tersedia dibangun dengan analisis frekuensi kemunculan kata pada sebuah korpus (corpus) teks, tanpa memperhatikan jenis kata ataupun kebiasaan pengguna internet. Hasil lain penelitian ini adalah beberapa rekomendasi lebih lanjut bagi para peneliti di bidang ini ketika membutuhkan daftar stopword bahasa Indonesia, yaitu daftar yang memperhatikan jenis kata dan kebiasaan pengguna internet melalui mesin perambah yang tersedia.AbstractMost of text-based information retrieval system uses indexing process. The system processes the texts in order to obtain the information essence. One of the process is stopword filtering, several words are being ignored based on a stopword list. Several Indonesian stopword list are available openly. Therefore, this paper evaluates the available lists based on Indonesian formal grammar, its preparation technique, and internet surfer habit. The results show all of the list are developed by term frequency analysis based on a text corpus. This paper also provides several recommendations for researcher both in text mining and text-based information retrieval field, developing stoplist by the word type and internet surfer habit.
Sistem Pendukung Keputusan Pemilihan Pramuka Pandega Berprestasi Menggunakan Metode Multi Objective Optimization on the Basis of Ratio Analysis
Authors: Ramadiani Ramadiani - , Rani Famylia Puspa , Khairina Dyna Marisa , Hatta Heliza Rahmania 
Published: February 2019

<p class="Judul2">Abstrak</p><p>Pemilihan Pramuka Pandega berprestasi, merupakan kegiatan rutin setiap tahun yang dilakukan oleh Pengurus Daerah Gerakan Pramuka Provinsi Kalimantan Timur. Kegiatan ini bertujuan untuk memilih wakil Pandega yang akan dikirim ke Jakarta. Pemilihan Pramuka Pandega yang terbaik didasarkan pada kriteria usia, Indeks Prestasi Kumulatif, jumlah perkemahan wirakarya yang pernah diikuti, kepribadian dan penampilan, peluang kerja yang dimiliki dan pretasi lain serta karya tulis. Namun dengan cara penilaian yang masih manual, hal ini dianggap cukup sulit, kurang produktif, subjektif dan lambat bagi tim penilai. Sistem Pendukung Keputusan diperlukan untuk memudahkan pekerjaan tim penilai dalam memutuskan siapa yang layak dipilih sebagai Pandega berprestasi secara mudah, objektif, professional dan transparan. Pemilihan Pandega berprestasi menggunakan metode Multi Objective Optimization on the Basis of Ratio Analysis, studi literatur dan wawancara pada tim penilai, serta metode waterfall untuk tahapan pengembangan sistemnya. Berdasarkan hasil dari beberapa penelitian, metode MOORA dipilih karena memiliki nilai cost dan benefit dalam menentukan keputusan. Penelitian ini telah menghasilkan rekomendasi untuk pemilihan Pandega berprestasi dengan hasil akurasi sebesar 100%.</p><p> </p><p><strong> <em>Abstract</em></strong></p><p class="Judul2"><em><em>Selection of Scouts Pandega achievers are an annual agenda organized by the Regional Board of the Scout Movement of East Kalimantan Province. This activity aims to elect Pandega representatives to be sent to Jakarta. The best selection of Pandega Scouts is based on the criteria of age, Grade Point Average, number of workshops that have been attended, personality and appearance, work opportunities that are owned and other achievements and writing. However, with calculations that have not been automated, this is considered quite difficult, not professional, not objective and slow for the assessment team. DSS is provided to help the assessment team complete their work professionally in deciding who is eligible to be chosen as Pandega to achieve easily, objectively, professionally and transparently. The selection of Pandega achieves using the MOORA method, literature study and interviews with the assessment team, and the waterfall method for the development stages of the system. Based on the results of several studies, the MOORA method is recommended because this method allows an assessment of the costs and benefits in the final decision. The final report of this study resulted in Pandega's achievement achievement based on 100% accuracy value</em></em></p>
Penilaian Penerimaan Teknologi E-Learning Pemrograman berbasis Gamification dengan Metode Technology Acceptance Model (TAM)
Authors: Pradana Fajar , Bachtiar Fitra Abdurrachman , Priyambadha Bayu 
Published: February 2019

<p class="Judul2"><em>E-learning</em> telah berkembang tidak hanya sekedar berbagi materi pembelajaran melalui internet, namun telah berevolusi menjadi tempat untuk kolaborasi, sosialisasi, <em>project based learning</em>, <em>refl</em><em>ective practise</em>, dan pembelajaran dengan simulasi. Untuk mewujudkan hal tersebut telah dikembangkan sebuah sistem <em>e</em><em>-learning </em><em>gamification</em> khusus bidang pemrograman. Penelitian ini menerapkan <em>Technology Acceptance Model</em> (TAM) untuk memeriksa faktor-faktor apa saja yang berpengaruh terhadap penerimaan sebuah teknologi baru yang diperkenalkan atau digunakan. Faktor-faktor yang digunakan dalam penelitian ini adalah <em>Perceived Usefullness</em> (PU), <em>Perceived Ease of Use</em> (PEU), <em>Perceived Social Influence</em> (PSI), <em>Perceived Enjoyment</em> (PE), <em>Intention of Engagement</em> (IoE), dan <em>Elearning Gamification Attitude</em> (EGA). Model TAM didasarkan beberapa hipotesis dan faktor yang berpengaruh. Hasil menunjukan bahwa TAM dapat digunakan untuk memeriksa penerimaan teknologi <em>e-learning gamification</em> bidang pemrograman. <em>Perceived Social Influence </em>(PSI) dan <em>Perceived Enjoyment</em> (PE) berkontribusi terhadap <em>Intention of Engagement</em> (IOE). Selain itu <em>Perceived Usefullnes</em> (PU), <em>Perceived Social Influence</em> (PSI), <em>Perceived Enjoyment</em> (PE), dan <em>Intention of Engagement</em> (IOE) berkontribusi terhadap <em>Elearning Gamification Attitude</em> (EGA).</p><p class="Abstrak"><strong><em>Abstract</em></strong></p><p class="Judul2"> <em>E-learning has evolved not only to share learning materials over the internet, but has evolved into a place for collaboration, socialization, project based learning, reflective practice, and simulated learning. To realize this has been developed a special e-learning gamification system in the field of programming. This study applies Technology Acceptance Model (TAM) to examine what factors influence the acceptance of a new technology introduced or used. The factors used in this study are Perceived Usefullness (PU), Perceived Ease of Use (PEU), Perceived Social Influence (PSI), Perceived Enjoyment (PE), Intention of Engagement (IoE), and Elearning Gamification Attitude (EGA) . The TAM model is based on several hypotheses and influencing factors. The results show that TAM can be used to check the acceptance of e-learning gamification technology in the field of programming. Perceived Social Influence (PSI) and Perceived Enjoyment (PE) contribute to the Intention of Engagement (IOE). In addition Perceived Usefullnes (PU), Perceived Social Influence (PSI), Perceived Enjoyment (PE), and Intention of Engagement (IOE) contribute to Elearning Gamification Attitude (EGA).</em></p>