bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive Predictive Value of Administrative Data for Neonatal Abstinence Syndrome
Authors: Maalouf Faouzi I. , Cooper William O. , Stratton Shannon M. , Dudley Judith A. , Ko Jean , Banerji Anamika , Patrick Stephen W. 
Published: December 2018

OBJECTIVES:
Neonatal abstinence syndrome (NAS) is a postnatal withdrawal syndrome experienced by some infants with opioid exposure. Hospital administrative data are commonly used for research and surveillance but have not been validated for NAS. Our objectives for this study were to validate the diagnostic codes for NAS and to develop an algorithm to optimize identification.

METHODS:
Tennessee Medicaid claims from 2009 to 2011 (primary sample) and 2016 (secondary sample; post–International Classification of Diseases, 10th Revision, Clinical Modification [ICD-10-CM]) were obtained. Cases of NAS were identified by using International Classification of Diseases, Ninth Revision, Clinical Modification code (2009–2011) 779.5 and ICD-10-CM code (2016) P96.1. Medical record review cases were then conducted by 2 physicians using a standardized algorithm, and positive predictive value (PPV) was calculated. Algorithms were developed for optimizing the identification of NAS in administrative data.

RESULTS:
In our primary sample of 112 029 mother-infant dyads, 950 potential NAS cases were identified from Medicaid claims data and reviewed. Among reviewed records, 863 were confirmed as having NAS (including 628 [66.1%] cases identified as NAS requiring pharmacotherapy, 224 [23.5%] as NAS not requiring pharmacotherapy, and 11 [1.2%] as iatrogenic NAS), and 87 (9.2%) did not meet clinical criteria for NAS. The PPV of the International Classification of Diseases, Ninth Revision, Clinical Modification code for NAS in clinically confirmed NAS was 91% (95% confidence interval: 88.8%–92.5%). Similarly, the PPV for the ICD-10-CM code in the secondary sample was 98.2% (95% confidence interval: 95.4%–99.2%). Algorithms using elements from the Medicaid claims and from length of stay improved PPV.

CONCLUSIONS:
In a large population-based cohort of Medicaid participants, hospital administrative data had a high PPV in identifying cases of clinically diagnosed NAS.
A negatív érzelmek és a szív- és érrendszeri betegségek összefüggései
Authors: Balog Piroska 
Published: December 2018

Abstract: With regard to cardiovascular health, the role of negative emotions, particularly that of depression, anxiety, vital exhaustion and hostility has been studied the most widely. Mainly the somatic symptoms of depression and, out of anxiety disorders, generalised anxiety and panic disorder have been linked to cardiovascular diseases. Based on an analysis of interviews of patients having suffered myocardial infarction, it was found that vital exhaustion (a combination of loss of energy, increased irritability, and general demoralization) is a precursor of infarction. Vital exhaustion has proven to contribute to the development of coronary heart diseases, being one of the most important risk factors in both sexes. With regard to hostility, studies show that anger suppression and destructive anger expression (blaming others) are closely linked to a higher incidence of coronary heart diseases. Evidence shows that the relationship between negative emotions and cardiovascular diseases is one of a two-way causality, that is, the presence of a cardiovascular disease may also enhance negative emotions, low heart rate variability playing a crucial role in both diseases. This study also presents interview questions suggested by the European Guidelines (2016) to estimate negative emotions related to coronary heart diseases. Orv Hetil. 2018; 159(48): 2005–2010.
LİSE ÖĞRETMENLERİNİN HAYAT BOYU ÖĞRENME EĞİLİMLERİ
Authors: GÖKYER Necmi 
Published: December 2018

Bu araştırmanın
amacı, lise öğretmenlerinin yaşam boyu öğrenme eğilimlerini belirlemek ve
çeşitli değişkenlere göre karşılaştırmaktır. Araştırmada, aşağıdaki sorulara
cevap aranmıştır.1. Lise öğretmenlerinin yaşam boyu öğrenme eğilimlerinin
düzeyi nedir? 2. Lise öğretmenlerinin yaşam boyu öğrenme eğilimleri; cinsiyet,
branş, kıdem, eğitim düzeyleri, yaşları ve çalıştıkları yer değişkenlerine göre
anlamlı farklılık göstermekte midir? 3. Ölçeğin alt boyutları arasında anlamlı
bir ilişki var mıdır? Bu araştırma anlık tarama modelindedir. Araştırmanın
evrenini, 2017-2018 eğitim öğretim yılında, Elazığ merkez ve ilçelerin
merkezindeki liselerde görev yapan toplam 2805 lise öğretmeni oluşturmaktadır.
Örneklemini ise, basit tesadüfi örnekleme yolu ile belirlenen toplam 343
öğretmen oluşturmaktadır. Araştırmada veri toplama aracı olarak, Diker Coşkun
ve Demirel (2009) tarafından geliştirilen “yaşam boyu öğrenme eğilimleri
(YBÖEÖ)” adlı ölçek kullanılmıştır. Bu çalışmanın bulgularına göre, lise
öğretmenlerinin yaşam boyu öğrenme eğilimleri; Güdülenme alt boyutunda çok
uyuyor, sebat, merak yoksunluğu alt
boyutlarında ve ölçeğin tamamında kısmen uyuyor düzeyinde iken, öğrenmeyi
düzenlemede yoksunluk alt boyutunda ise, çok az uyuyor düzeyindedir. Cinsiyet
değişkenine göre, bütün alt boyutlarda kadın lise öğretmenlerinin yaşam boyu
öğrenme eğilimlerinin düzeyi erkeklere göre daha yüksektir.
Optical biometry features in silicon oil filled eyes
Authors: Kulikov Alexey N. , Kokareva Ekaterina V. , Kuznetsov Alexander R. 
Published: December 2018

Background. The article presents results of axial length (AL) measurement in eyes filled with silicone oil and in those without silicone oil with IOLMaster and Lenstar LS 900 optical biometry methods.
Materials and methods. The anteroposterior axis was measured in 27 eyes of 27 patients with silicone oil tamponade after surgical treatment of several vitreoretinal conditions. Using IOLMaster, the AL of eyes without silicone oil tamponade varied from 21.99 mm to 29.38 mm, Lenstar LS 900 biometry gave results from 21.96 mm to 29.41 mm.
Results. According to data obtained and to their distribution, all cases were divided into 2 groups: I group eyes with AL less than 23.63 mm, and II group eyes with AL more than 23.63 mm. In the group II, the disparity of consecutive measurements was reliable and amounted to 0.28 0.46 mm (р = 0.024) for IOLMaster and 0.23 0.44 mm (р = 0.029) for Lenstar LS 900.
Conclusion. So AL values at IOLMaster and Lenstar LS 900 biometry of silicone oil filled eyes may significantly overestimate the real ones when exceeding 23.63 mm. In case of simultaneous phacoemulsification with IOL implantation, this could lead to hypermetropic shift of postoperative refraction. Lenstar LS 900 measurement error in silicon oil filled eyes is less than that of IOLMaster, thus making the first biometry method preferable. In eyes with AL shorter than 23.63 mm, the measurement difference was not reliable, thus the biometry accuracy in silicone oil filled short eyes becomes higher.
Analysis of retinal and optic nerve electrogenesis dynamics after vitrectomy for complicated catarct surgery
Authors: Kulikov Alexey N. , Sosnovskii Sergey V. , Nikolaenko Evgeniya N. 
Published: December 2018

Background. The article presents impact results of vitrectomy for complicated cataract surgery on retinal and optic nerve electrogenesis.
Materials and methods. 30 patients (30 eyes) with history of dropped nucleus (1st group) or intraocular lens dislocated into the vitreous cavity after phacoemulsification (2nd group) underwent electrophysiological examination before vitrectomy, and on Day 1, Day 3, Day 7, Day 14, Day 30, Day 60, and Day 180 after surgery.
Results. In the 1st and 2nd groups, on the 1st day after vitrectomy, we observed a significant decrease in retinal and optic nerve electrogenesis in comparison to normal indices (p 0.01); to Day 180, electrophysiologic indices returned to normal values. In the 1st group, baseline retinal and optic nerve electrogenesis was decreased in comparison to normal parameters. In the 1st and 2nd groups, the electrogenesis of photoreceptors recovered twice as rapidly, as that of bipolar cells; papillomacular bundle neurons were more resistant to vitrectomy.
Conclusion. Thus, the presence of lens nucleus fragments in the vitreous cavity results in a reliable inhibition of the retinal and optic nerve electrogenesis due to phacotoxic effect. Vitrectomy causes a short-term depression of the retinal and optic nerve electrogenesis, followed by normalization of indices to Day 180. Photoreceptors have greater rehabilitation activity than bipolar cells. The neurons of axial topographic orientation have the highest resistance to vitrectomy impact.
Peculiarities of ocular prosthetics in congenital anophthalmia and microphthalmia
Authors: Baranova Nadezhda A. , Nikolaenko Vadim P. 
Published: December 2018

Aim to determine optimal terms of the primary ocular prosthetics, to develop the most auspicious regimen of adaptation to the ocular prosthesis in children with congenital anophthalmia and microphthalmia.
Material and methods. A total of 46 children aged from 1 month to 16 years with congenital defect were under observation. Among patients with congenital microphthalmia, only unpromising eyes were subject to ocular prosthetics. Examination methods in the laboratory included external examination of the orbit, palpebral fissure, and eyelids. The state of the cul-de-sac of eyelids, the configuration of the conjunctival cavity, the anterior segment of the abnormally small eyeball were assessed. Photography was performed to achieve a dynamic control of external prosthetics signs of, and to evaluate the face symmetry.
Results. Best results were observed at early stepwise ocular prosthetics with consideration of features of the ocular prosthesis material, without prior surgery. Long-term cosmetic performance of children with congenital anophthalmia and microphthalmia directly depended on age at which the non-surgical treatment began, on the timely replacement of the ocular prosthesis, compliance to the regimen developed for the adaptation to the prosthesis.
Conclusion. This study showed that the terms of primary ocular prosthetics are of crucial importance for the symmetrical development of soft tissues and facial skeleton. Prosthetics for patients with congenital anophthalmia should be started at the first month of life. The optimal term for primary prosthetics in congenital microphthalmia depends on the length of the antero-posterior axis at birth. If the axial length is less than 7.5 mm, prosthetics should be started at the first month of life, if the axis is longer than 10 mm no later than from the fourth month of life.
A rare case of mechanical conjunctivitis
Authors: Riks Inna A. , Papayan Sanasar S. , Nechiporenko Pavel A. 
Published: December 2018

Introduction. Mechanical conjunctivitis is a rare form of eye surface inflammatory condition. One of its types, a mucus fishing syndrome, leads to a chronic eye surface trauma.
Purpose. To review the available literature data on the mechanical conjunctivitis prevalence, and to describe the diagnosis and treatment methods of its rare type, the mucus fishing syndrome.
Materials and methods. The article describes the case of the mucus fishing syndrome development in a patient suffering from this type of mechanical conjunctivitis for about 3 years.
Results. The correct diagnosis was not established in our patient for a long period of time that is why an improper treatment had been prescribed, which led to complications and to the need for surgical treatment.
Conclusions. The prevalence of mechanical conjunctivitis is low, and in the available literature, there are only 4 publications on the topic. The mucus fishing syndrome should be treated in cooperation with a psychiatrist, since the usual use of topical reparative and lubricating therapy is not enough.
María y El Alférez Real: de Jorge Isaacs a Eustaquio Palacios. Tras la huella de una narrativa patriarcal y burguesa en el Valle del Cauca
Authors: Alzate Alejandro 
Published: December 2018

This article aims to analyze and describe both the presence and meaning of the agrarian bourgeoisie in Cauca Valley and the moral and economic values inherent to it. María and El Alférez Real, the two most representative regional novels of the nineteenth century, are the ideal inquiry scenario; not only because they are foundational of the literature of the south-west of Colombia, but also because they reflect the tensions and ambiguities typical of the post-independence period, which was torn between pretension to freedom and an ongoing colonial mentality.
Study of social and demographic determinants of severe acute malnutrition in children aged 6-59 months in a tertiary care centre of Odisha, India
Authors: Jena Pravati , Rath Soumini , Nayak Manas Kumar , Satapathy Diptirekha 
Published: December 2018

Background: The objective is to study the various social and demographic determinants of severe acute malnutrition in children aged 6 months to 59 months in a tertiary care centre of Odisha, India.Methods: This is a hospital based prospective observational study done in a tertiary care centre of Odisha during the period of Nov 2015 to Oct 2017 in which all children with severe acute malnutrition as per WHO criteria in the age group 6 months to 59 months were enrolled and their socioeconomic and demographic details were evaluated.Results: Present study revealed a prevalence of severe acute malnutrition as 2.8%. Males (54.2%) were more affected than females (45.8%). Most common age group affected was 6-12 months (37.4%). Most of the children were from low socioeconomic status (96.4%) and from rural areas (84.8%).63.7% of the study population were unimmunised. Only 12.6% of the participants were exclusively breast fed.100% of the children in the study population received top feeding with cow’s milk.Conclusions: The prevalence of malnutrition is high in Odisha but most of the causative factors are preventable. Adequate education regarding exclusive breastfeeding, complementary feeding, immunisation, promotion of proper referral and health care services can help to improve nutritional status in the state of Odisha.
Botulismo Alimentar: Uma Doença Esquecida
Authors: Neves Paula , Vicente Jorcélio , Cabrera Heidy , Pantazi Iurie 
Published: December 2018

O botulismo é uma doença grave causada pela exposição a toxina botulínica. Manifesta-se por paralisia flácida, simétrica e em padrão descendente que afeta nervos cranianos e periféricos. Dada a frequente necessidade de ventilação mecânica invasiva, estes doentes devem ser abordados em ambiente de cuidados intensivos. O tratamento com soro anti-toxina botulínica é o único eficaz. Os autores apresentam o caso de uma doente de 64 anos, com quadro de vómitos e vertigem, com evolução para diplopia, disfagia e parésia muscular flácida, simétrica e descendente, com instalação após ingestão de conserva alimentar de fabrico caseiro. Do estudo etiológico salienta-se eletroneuromiograma com lesão pré sináptica compatível com hipótese de botulismo. Melhoria progressiva dos défices após administração de soro anti-toxina botulínica. Faz-se uma breve revisão teórica de uma patologia grave, potencialmente fatal e pouco frequente no nosso país.
THE ASSESSMENT OF EFFICACY AND OF SAFETY USING SELF-MONITORING OF DISEASE ACTIVITY VIA INTERNET PORTAL IN THE MANAGEMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: Bagirova G. G. , Lygina E. V. , Yakushin S. S. , Kozminskaya M. I. 
Published: December 2018

Objectives:Maximally quickly identify the exacerbation of the disease and timely strengthen the therapy, for more rapid achievement of remission or low disease activity.Methods:The authors created an interactive web portal for self-monitoring of RA activity. The patient management model using this method is that a patient conducts a monthly self-evaluation of the disease activity and transmits this information to his treating doctor in a remote manner via the web portal. In case of worsening and in the absence of any dynamics, according to the patient, he was invited to the center, where this information was verified by a doctor. If, in the patient’s opinion, there was an improvement, he did not come to clinic, but continued therapy. Currently, 30 women with RA, age 57 (38; 71), who completed the 6-month treatment period, are included in the study. 20 women included in the control group, average age 60.5(40; 77).Results:During 6 months, there was a positive dynamic of the course of the disease, the activity of the RA by DAS 28 decreased. Initially, 5 patients (16.7%) had high DAS activity, 24 — moderate (80%), 1low (3.3%). After 6 months of treatment 8 patients (26.7%) had low activity, 22 (73.3%) achieved remission. The mean value of the DAS 28 index at the time of inclusion was 3.99 (2.46; 5.78) and after 6 months of management 2.175 (0.79; 4.31), a statistically significant decrease (Wilcoxon T-test = 5). The DAS 28 index at the time of control group was 4,1 (2.46; 5.78) and after 6 months of management 3,9 (0.79; 4.31), a statistically significant decrease (Wilcoxon T-test = 5). Analysis of clinical and laboratory parameters did not reveal statistically significant deviations.Conclusions:The 6-month period of patient management via the Internet portal for self-monitoring of rheumatoid arthritis activity proved the possibility of achieving remission and low disease activity in all patients.
Legal Standing Lembaga Perlindungan Konsumen Swadaya Masyarakat (LPKSM) Dalam Perkara Ekonomi Syari’ah di Pengadilan Agama
Authors: Azizah Siti 
Published: December 2018

Abstract: This study aims to analyze legal standing restraints of LPK authorized by law to litigate in the Religious Courts in sharia economic cases and to explain the reasons and legal considerations of the judges of Religious Courts of Madiun in the decision of case number: 403 / Pdt. G / 2014 / PA.Mn. This research employed a qualitative approach by systematically describing the right of Consumer Protection Institution of Sharia Institution and legal consideration of judges of Religious Court of Madiun in case verdict number: 403 / Pdt.G / 2014 / PA.Mn then it analyzed thoroughly to find the legal standing of the Consumer Protection Institution in the case of sharia economy in the Religious Courts.The findings showed that Article 46 verse (1) letter c of Law No. 8 of 1999 on Consumer Protection is associated with the main principle in Law No. 7 of 1989 related to the subject of law is the applicability of the Islamic personality has authorized LPKSM to propose a sharia economic case in the Religious Courts in the framework of protecting consumers in certain terms and conditions. The next findingis that the judges of the Religious Court of Madiun deemed the legal standing that has been guaranteed by the law, in consideration of the non-acceptance of cases by LPKSM merely because of defects in the power of attorney made by consumers to LPKSM.Abstrak: Penelitian ini bertujuan untuk mengetahui dan menjelaskan batasan legal standing LPK yang diberi kewenangan oleh undang-undang untuk berperkara di Pengadilan Agama dalam perkara ekonomi syariah dan mengetahui serta menjelaskan alasan dan pertimbangan hukum majelis hakim Pengadilan Agama Kota Madiun dalam putusan perkara nomor:403/Pdt.G/2014/PA.Mn. Peneletian ini menggunakan pendekatan kualitatif dengan menguraikan secara sistematik tentang hak gugat Lembaga Perlindungan Konsumen Swadaya Masyarakat Lembaga syariah dan pertimbangan hukum majelis hakim Pengadilan Agama Kota Madiun dalam putusan perkara nomor:403/Pdt.G/2014/PA.Mn kemudian menganalisanya dengan seksama sehingga menghasilkan temuan mengenai legal standing Lembaga Perlindungan Konsumen Swadaya Masyarakat dalam perkara ekonomi syariah di Pengadilan Agama. Berdasarkan proses pengumpulan data dan analisis data, penelitian ini menghasilkan temuan-temuan bahwa Pasal 46 ayat (1) huruf c UU No 8 Tahun 1999 Tentang Perlindungan Konsumen dikaitkan dengan prinsip utama dalam UU No 7 Tahun 1989 terkait dengan subyek hukum adalah berlakunya asas personalitas keislaman telah memberikan kewenangan kepada LPKSM untuk mengajukan perkara ekonomi syariah di Pengadilan Agama dalam rangka perlindungan terhadap konsumen dengan beberapa syarat dan ketentuan yang harus dipenuhi. Temuan berikutnya, majelis hakim Pengadilan Agama Kota Madiun tidak mempertimbangkan negative terhadap legal standing yang telah mendapat jaminan undang-undang, dalam pertimbangan tidak diterimanya perkara yang diajukan oleh LPKSM semata-mata karena ada cacat dalam surat kuasa yang dibuat konsumen kepada LPKSM.
Multiphase mesh-free particle modeling of local sediment scouring with μ(I) rheology
Authors: Nodoushan Ehsan Jafari , Shakibaeinia Ahmad 
Published: December 2018

AbstractSediment scouring is a common example of highly dynamic sediment transport. Considering its complexities, the accurate prediction of such a highly dynamic multiphase granular flow system is a challenge for the traditional numerical techniques that rely on a mesh system. The mesh-free particle methods are a newer generation of numerical techniques with an inherent ability to deal with the deformations and fragmentations of a multiphase continuum. This study aims at developing and evaluating a multiphase mesh-free particle model based on the weakly compressible moving particle semi-implicit (WC-MPS) formulation for simulation of sediment scouring. The sediment material is considered as a non-Newtonian viscoplastic fluid, whose behavior is predicted using a regularized μ(I) rheological model in combination with pressure-dependent yield criteria. The model is first validated for a benchmark problem of viscoplastic Poiseuille flow. It is then applied and evaluated for the study of two classical sediment scouring cases. The results show that the high-velocity flow currents and the circulations can create a low-viscosity region on the surface of the sediment continuum. Comparing the numerical results with the experimental measurements shows a good accuracy in prediction of the sediment profile, especially the shape and dimensions of the scour hole.
p53-Mediated Anticancer Activity of Citrullus colocynthis Extracts
Authors: Joshi Gaurav , Kaur Jatinder , Sharma Praveen , Kaur Gurpreet , Bhandari Yuvraj , Kumar Raj , Singh Sandeep 
Published: December 2018

Background:
Current anticancer therapeutics comes with significant side effects and thus
focus is shifting towards minimizing the side effects or to avoid the disease altogether. Thus, various
natural products are being investigated for their potential therapeutic values which can be easily included
in daily diet of a person. Citrullus colocynthis (L.) fruit is commonly used in traditional medicines
and is known to have antioxidant effects, thus may possess potent anticancer activity as well.

Objectives:
To establish the anticancer potential of fruit belonging to Citrullus colocynthis (L.) and
delineate the potential targets.

Results:
In the present study it was found that seed and pulp extracts of the fruit are effective against
various cancer cell lines while the normal cells, with lower rate of division, remain largely unaffected.
The current study for the first time shows that these extracts function via regulation of p53
pathways and the mode of apoptosis is mostly via mitochondrial (intrinsic) pathway. The biological
profiling of the extracts was also validated using molecular modelling studies utilizing the two major
polyphenols constituents from colocynths i.e., Isoorientin and Isovitexin.

Conclusion:
The study suggested that the constituent has a multiple target approach for the inhibition
of cancer cell proliferation and inhibition of ROS production via the major apoptotic proteins.
All of these outcomes suggest and establish a critical role of ROS accumulation and mitochondrial
function in the p53-dependent cell.