bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contamination of skin and surfaces by cobalt in the hard metal industry
Authors: Kettelarij Jolinde , Midander Klara , Lidén Carola , Julander Anneli 
Published: July 2018

BackgroundIt is well known that hard metal workers have historically been affected by contact allergy to cobalt. Knowledge is sparse about occupational skin exposure to cobalt, in terms of skin doses and sources of exposure, which could be used to improve protection of workers.ObjectivesTo improve knowledge about skin doses and sources of skin exposure to cobalt within hard metal production, thereby facilitating better protection of workers.MethodsForty workers were sampled on the index finger by acid wipe sampling after 2 hours of work. The samples were analysed with inductively coupled plasma mass spectrometry. Cobalt spot testing was performed in the work environment.ResultsThe highest skin doses were found among raw material workers. Skin doses among other production workers were also significant. Most office workers had low, but measurable, levels of cobalt on the skin. Glove use varied between workers. Cobalt was found on production equipment, on items in the canteen area, and on handles and buttons throughout the company.ConclusionsCobalt skin doses were prominent, and originated from contact with raw materials, sintered materials, and contaminated surfaces. Cobalt was present on surfaces outside production areas. Companies need to identify and reduce skin exposure for protection of workers.
Creating a Female‐Responsive Design Framework for STEM exhibits
Authors: Dancstep (née Dancu) Toni , Sindorf Lisa 
Published: July 2018

AbstractThis paper describes the development of a Female‐Responsive Design Framework for Informal Science Education (ISE). The FRD Framework translates ideas from Culturally Responsive Pedagogy to discover and recommend pedagogical strategies that apply to females and design. This paper describes our synthesis of prior research about females’ social, historical, and cultural practices in STEM learning from a variety of fields. The paper further details our process of developing the FRD Framework with the help of museum practitioners, female youth, researchers, and experts from the fields of design, gender, and museums. We discuss four female‐responsive strategies, and suggest multiple STEM exhibit design attributes that support each of these strategies. This framework contributes to a growing movement to more thoughtfully consider females when designing STEM exhibits. We hope that the museum field will expand, evolve, and deeply explore the FRD Framework.
The loss of large wood affects rocky mountain trout populations
Authors: Herdrich Adam T. , Winkelman Dana L. , Venarsky Michael P. , Walters David M. , Wohl Ellen 
Published: July 2018

AbstractWestern U.S. rivers are currently influenced by legacy effects of reduced large wood (LW) loading and retention that has substantially reduced in‐stream habitat complexity. Large wood is typically associated with streams in undisturbed old‐growth forest and in the correct geomorphic context can drastically alter stream and valley habitat complexity. Streams withLWare typically multichannel and depositional, while streams lackingLW, due to relatively recent wildfire or logging (<200 years ago), are usually single channelled and erosional. We compared population biomass and individual growth rates of Brook TroutSalvelinus fontinalisin streams across a gradient of wood volumes. At both the square metre and valley length scales, standing stock biomass of aquatic invertebrates was the best predictor of trout biomass. However, at the valley scale, the number of pools was important in predicting trout biomass in combination with standing stock biomass of aquatic invertebrates. Individual growth rates of age‐1 Brook Trout were negatively affected by increasing density; however, growth rates for the largest and smallest individuals at each site were unaffected by density. Our results suggest the pool habitat created byLWacts synergistically with prey availability to dramatically increase trout populations. However, in streams lacking LW, negative effects of detrimental land use practices have persisted >100 years, suggesting that recovering lost animal production in mountain stream networks will only occur at decadal to century time scales.
Rhithronic and potamonic fishes coexist in wadeable streams under distinct metacommunity processes
Authors: Ferreira Fabio C. , Souza Ursulla P. , Cetra Maurício , Petrere Miguel 
Published: July 2018

AbstractRecent metacommunity ecology research has demonstrated that local communities can be divided into different guilds. We hypothesised that wadeable streams are occupied by fishes that follow distinct metacommunity processes. The mainstem is a river corridor for the potamonic fish guild (PFG) but represents a nonhabitat matrix for the rhithronic fish guild (RFG). Accordingly, the PFG should be filtered out from the headwaters by dispersal limitations or environmental filtering along the longitudinal gradient, and the guild should have a nested pattern of beta diversity. The RFG should be structured by the local species sorting, and the species turnover component should prevail. We sampled fishes in 42 streams distributed in four subbasins that were separated by at least one mainstem channel. We modelled the influences of spatial and environmental predictors using a partial redundancy analysis and variance partitioning and by quantifying the components of beta diversity that were associated with species turnover and nestedness. Both environment and space affected the structure of the RFG, owing to the influence of substrate type, riparian cover and presence of downstream barriers. The PFG was structured by only the influence of downstream barriers. Species turnover predominated within the RFG, and species nestedness dominated within the PFG. Our results support the hypothesis that potamonic and rhithronic guilds coexist in wadeable streams and follow distinct metacommunity assembly mechanisms. Potamonic guilds are structured by regional dispersal from the mainstem channels, whereas rhithronic guilds are sorted by local filtering along the longitudinal gradient in a spatially structured environment.
WONOEP APPRAISAL: The many facets of epilepsy networks
Authors: Scott Rod C. , Menendez de la Prida Liset , Mahoney J. Matt , Kobow Katja , Sankar Raman , de Curtis Marco 
Published: July 2018

SummaryThe brain is a complex system composed of networks of interacting elements, from genes to circuits, whose function (and dysfunction) is not derivable from the superposition of individual components. Epilepsy is frequently described as a network disease, but to date, there is no standardized framework within which network concepts applicable to all levels from genes to whole brain can be used to generate deeper insights into the pathogenesis of seizures or the associated morbidities. To address this shortcoming, the Neurobiology Commission of the International League Against Epilepsy dedicated a Workshop on Neurobiology of Epilepsy (XIV WONOEP 2017) with the aim of formalizing network concepts as they apply to epilepsy and to critically discuss whether and how such concepts could augment current research endeavors. Here, we review concepts and strategies derived by considering epilepsy as a disease of different network hierarchies that range from genes to clinical phenotypes. We propose that the concept of networks is important for understanding epilepsy and is critical for developing new study designs. These approaches could ultimately facilitate the development of novel diagnostic and therapeutic strategies.
A PRRT2 variant in a Chinese family with paroxysmal kinesigenic dyskinesia and benign familial infantile seizures results in loss of interaction with STX1B
Authors: Ma Hongying , Feng Shenglei , Deng Xuejun , Wang Li , Zeng Sheng , Wang Cheng , Ma Xixiang , Sun Hao , Chen Rui , Du Shiyue , Mao Jinglin , Zhang Xianwei , Ma Cong , Jiang Hong , Zhang Luoying , Tang Beisha , Liu Jing Yu 
Published: July 2018

SummaryObjectiveTo identify the causative gene of autosomal dominant paroxysmal kinesigenic dyskinesia and benign familial infantile seizures (PKD/BFIS) in a large Chinese family and explore the potential pathogenic mechanism of a PRRT2 (proline‐rich transmembrane protein 2) variant.MethodsGenetic testing was performed via whole exome sequencing. Western blotting and immunofluorescence were used to analyze the protein expression level and subcellular localization of the PRRT2 mutant in HeLa cells and N2A cells. Coimmunoprecipitation was conducted to investigate the interaction of the PRRT2 mutant with syntaxin 1B (STX1B).ResultsIn a large Chinese family with autosomal dominant PKD/BFIS showing wide phenotypic heterogeneity, including patients suffering from PKD, BFIS, or epilepsy and asymptomatic variant carriers, a c.621dupA variant in PRRT2 was identified in the proband and was shown to cosegregate with the phenotype in this family. This variant results in premature termination at codon 224, producing a truncated protein (p.Ser208Ilefs*17) in which the two conserved hydrophobic segments and the cytoplasmic loop are missing. Both the expression and subcellular localization of PRRT2 are strongly affected by the c.621dupA variant. In addition, we found that PRRT2 directly interacts with STX1B, a SNARE protein critical for neurotransmitter release, whereas the truncated variant p.Ser208Ilefs*17 lacking the helix‐loop‐helix domain fails to bind to STX1B.SignificanceOur findings identified a PRRT2 variant in a family with PKD/BFIS and confirmed STX1B as a new binding partner of PRRT2, which suggested that the loss of the interaction between PRRT2 and STX1B may contribute to the pathogenesis of PKD/BFIS.
Stress distribution and fatigue crack propagation analyses in welded joints
Authors: Dong Y. , Guedes Soares C. 
Published: July 2018

AbstractAn approach is presented, based on the weight function method to calculate the stress intensity factors of semielliptical surface cracks originating from the notch root of welded joints. The stress distribution along the potential crack plane required in the weight function method is constructed on the basis of the notch stress intensity factor approach in the highly stressed zone and of the equivalent linearized stress distribution and is compared with those determined by the finite element method and existing predictions. The stress intensity factors determined by the proposed approach are compared with available solutions. These comparisons show that the results determined by the proposed approach generally agree well with the existing solutions. For the cases where the agreement is poor, the reasons are identified. One important feature of the proposed approach is that the stress singularity at sharp notch tip can be considered, which cannot be appropriately simulated by the finite element method. Finally, to demonstrate the applicability of the proposed approach, the fatigue life and the fatigue crack shape evolution of welded joints are predicted and they are compared with experimental results.
Progressive changes in lithological association of the Sanbagawa metamorphic complex, Southwest Japan: Relict clinopyroxene and detrital zircon perspectives
Authors: Endo Shunsuke , Miyazaki Kazuhiro , Danhara Tohru , Iwano Hideki , Hirata Takafumi 
Published: July 2018

AbstractThe main tectono‐stratigraphic unit (Shirataki unit) of the Sanbagawa metamorphic complex in central Shikoku is characterized by abundant mafic schist layers that show the mid‐ocean ridge basalt (MORB) affinity. These MORB‐derived schist layers are absent in a southern (structurally lower) domain within the unit. Instead, sporadic occurrences of small metabasite lenses that contain relict igneous minerals (Ti‐rich augite and kaersutite) indicative of alkali basalt magmatism are newly recognized in the southern domain. Compositions of relict clinopyroxene in metabasalt are useful to identify the tectonic setting and origin of the protolith basalt, and those in each unit of the Sanbagawa metamorphic complex are presented. The metamorphic grade of the Shirataki unit generally increases structurally upwards in the southern side of the highest‐grade zone, and metamorphic zonation is subparallel to lithostratigraphic succession. The protolith assemblage of the Shirataki unit shows a distinct change from the southern low‐grade domain (lower Shirataki subunit) composed of terrigenous sedimentary rocks (mudstone and sandstone) with minor alkali basalt to the northern higher‐grade domain (upper Shirataki subunit) consisting of terrigenous and pelagic sedimentary rocks with abundant MORB. The youngest detrital zircon U–Pb ages (ca 95–90 Ma) suggest that both domains have Late Cretaceous depositional ages at the trench. Progressive peeling of oceanic plate stratigraphy during subduction can account for the observed change of lithological association in the Shirataki unit.
Social support for elderly people over 65 years in Spain
Authors: López‐Cerdá E. , Carmona‐Torres J.M. , Rodríguez‐Borrego M.A. 
Published: July 2018

AimsTo determine what social support is available in Spain to people over 65 who also dedicate hours of their time to the care of others who are older.BackgroundDemographic and social changes are leading to growth of the population. The social support available to older people in the final stage of life affects their health.MethodsA cross‐sectional study was conducted involving the records of older, non‐institutionalized individuals residing in Spain, obtained from the European Health Survey of 2014. The method of collecting information used in the European Survey was personal interviews assisted by a computer.ResultsThe records of 6520 older people were studied; 40.1% of the participants studied had expressed the possibility of having three to five people available in case of a serious problem, and 83.6% reported that the rest of the people around them were very interested in what happens to them. With respect to care, only 7% of the older people studied mentioned performing care tasks.ConclusionsSocial support is beneficial to older people, regardless of whether they perform care tasks, because it acts as a protective factor against problems such as loneliness, stress and depression. The profile of a primary caregiver in this age range is a married, middle‐class woman with primary schooling who is caring for a first‐degree relative.Implications for nursing and health policyThese data suggest that it is necessary for nurses to know about the needs of older people to implement societal measures of health promotion, prevention and education that favour social cohort. In addition, health policymakers should establish programmes that improve the social support of non‐institutionalized older people.
Different associations between body composition and alcohol when assessed by exposure frequency or by quantitative estimates of consumption
Authors: Lean M. E. J. , Vlachou P. , Govan L. , Han T. S. 
Published: July 2018

AbstractBackgroundAlcohol intake is widely assumed to contribute to excess body fatness, especially among young men; however, the evidence is inconsistent. We have addressed this research question by investigating associations between reported alcohol consumption and body composition from large representative national surveys in a high alcohol‐consuming country with a high obesity prevalence.MethodsThe present study comprised a secondary analysis of combined cross‐sectional nationally representative Scottish Health Surveys (1995–2010). Reported alcohol‐drinking frequency was divided into five groups: from ‘nonfrequent drinking’ (reference) to daily/‘almost every day’ among 35 837 representative adults [mean (SD) age: 42.7 (12.7) years (range 18–64 years)]. Quantitative alcohol consumption was categorised into seven groups: from ‘1–7 to ≥50 10 g units per week’. Regression models against measured body mass index (BMI) and waist circumference (WC) were adjusted for age, physical activity, income, smoking, deprivation category and economic status.ResultsAmong alcohol‐consuming men, heavier drinking (21–28 units per week) was associated with a higher BMI by +1.4 kg m–2 [95% confidence interval (CI) = 1.38–1.43] and higher WC by +3.4 cm (95% CI = 3.2–3.6) than drinking 1–7 units per week. However, those who reported daily drinking frequency were associated with a lower BMI by −2.45 kg m–2 (95% CI = −2.4 to −2.5) and lower WC by −3.7 cm (95% CI = −3.3 to −4.0) than those who reported less‐frequent drinking. Similar associations were found for women. Most of these associations were restricted to subjects aged >30 years. Unexplained variances in BMI and WC are large.ConclusionsQuantitative alcohol consumption and frequency of consumption were positively and inversely associated, respectively, with both BMI and WC among alcohol‐consuming adults. Surveys are needed that evaluate both the quantity and frequency of consumption. The lowest BMI and WC were associated with a ‘Mediterranean’ drinking style (i.e. relatively little, but more frequently).
Multipolydioxanone scaffold improves upper lip and forehead wrinkles: A 12‐month outcome
Authors: Ko Hyun Ju , Choi Sun Young , Kim Jae Min , Kim Hyuk , Choi Jin Kyu , Bae Il‐Hong , Lee Jin Woo , Ko Eun Jung , Kim Beom Joon 
Published: July 2018

SummaryBackgroundThe safety and wrinkle‐reducing effects of multipolydioxanone (PDO) scaffold have been confirmed in animal, and clinical tests for 3 months, but the 12‐month outcomes, are unknown.ObjectiveThe safety and efficacy of multi‐PDO scaffold were tested in animal models and in humans for 12 months.MethodsIn the animal study, a multi‐PDO scaffold was implanted into the panniculus carnosus of rat dorsal skin (n = 18) and into the subcutaneous layer of minipig dorsal skin (n = 2) followed by histological staining and analysis. In a human study, a multi‐PDO scaffold was implanted deep into the periosteal subcutaneous layer under the wrinkles on the upper lips and forehead, followed by evaluation of clinical changes using digital photography and PRIMOS.ResultsA multi‐PDO scaffold was not observed after 6 months in rats and minipigs. However, the newly formed tissues within the hollow body of the scaffolds were maintained for up to 12 months. The enhanced effect on the upper lips and forehead wrinkles lasted up to 12 months without any side effects.ConclusionA multi‐PDO scaffold represents a new tool to improve upper lips and forehead wrinkles.
“I Shot the Sheriff”: Irony, Sarcasm and the Changing Nature of Workplace Resistance
Authors: Alcadipani Rafael , Hassard John , Islam Gazi 
Published: July 2018

AbstractThe spread of Lean management has fuelled debates over the changing nature of workplace domination. While Lean discourses often espouse a ‘human relations’ approach, research has suggested the proliferation of coercion systems and questioned whether Lean is instead shorthand for cost‐cutting and new forms of domination. The varied interpretations of Lean have explained the heterogeneity of worker responses, including forms of resistance. Our ethnography explores this heterogeneity by examining the implementation of Lean in a printing factory and tracing the emergence of shopfloor opposition. Various tactics were devised by workers, ranging from tangible procedures such as sabotage and working‐to‐rule to more subtle forms reflecting irony and contempt. We argue that the distinctive manifestations of domination emerging during the Lean programme stimulated particular forms of worker reaction, which are explained through fieldwork illustrations. Overall, we produce a theoretical explanation of domination and resistance that builds upon and extends the extant scholarship.
Follow the Crowd or Follow the Trailblazer? The Differential Role of Firm Experience in Product Entry Decisions in the US Video Game Industry
Authors: Ozalp Hakan , Kretschmer Tobias 
Published: July 2018

AbstractFirms take cues from their external environment under uncertainty and imitate the actions of others. However, a firm’s own experience may either substitute for these external clues because the firm can evaluate uncertain situations more accurately, or it may complement them because the firm can act more successfully on the external cues. We argue that the type of external cues determines which of the two holds in the context of product entry decisions into market niches. If firms observe a large wave of entrants, own experience conveys more information than the imprecise signal of a mass of other firms. Conversely, if firms observe trailblazers, i.e., highly successful and influential products in a niche, own experience can help firms develop a strategy as a fast follower in a growing niche. We expect the supporting role of own experience in following trailblazers to be especially pronounced in niches that have not been discovered by a large mass of other firms. We study and test our hypotheses in the context of the US PC video game industry between 1991 and 2010 and find support for both the substitutive relationship between own experience and niche popularity and the complementary relationship of own experience and niche trailblazers. However, support for the complementary relationship is limited to less populated niches.
How Competitive Action Mediates the Resource Slack–Performance Relationship: A Meta‐Analytic Approach
Authors: Carnes Christina Matz , Xu Kai , Sirmon David G. , Karadag Reha 
Published: July 2018

AbstractThe fungibility of organizational slack provides firms significant latitude in addressing both internal and market pressures. A vast literature suggests that slack influences firm performance; however, the empirical record is mixed, and the underlying mechanism linking slack to performance remains ambiguous. We address these issues by theoretically expanding the slack–performance model to include mediation. Specifically, we develop and test a model in which a firm’s competitive behaviours direct the utilization of slack toward the realization of firm performance. Our meta‐analytic‐based structural equation model supports partial mediation, showing that competitive behaviours provide some resolution to the conflicted understanding of how slack affects performance. Further, we provide value to the slack literature by consolidating the evidence for the effects of various types and forms of organizational slack. Beyond providing robustness to our theoretical model, doing so offers a more complete understanding of how operationalizations of slack and performance outcomes matter.
Alliance Portfolio Diversity and Innovation: The Interplay of Portfolio Coordination Capability and Proactive Partner Selection Capability
Authors: Degener Philip , Maurer Indre , Bort Suleika 
Published: July 2018

AbstractThis study seeks to explain how the innovation potential entailed in the structural characteristics of a diverse alliance portfolio can be leveraged by two different alliance management capabilities of a focal firm: portfolio coordination and proactive partner selection. An analysis of German biotechnology firms, based on database and survey data, indicates that each alliance management capability positively interacts with portfolio diversity to foster innovation. In addition, regarding their joint influence as capability bundle on the portfolio diversity–innovation link, portfolio coordination and proactive partner selection seem to substitute rather than complement each other. These results suggest that firms realize innovation benefits from a diverse set of external alliance partners only when they focus on and apply internal coordination or partner selection routines to manage these alliances, thus acting as either portfolio coordinators or portfolio configurators.