bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges to mangroves of the Semiarid Equatorial Coast of Brazil in the Anthropocene
Authors: Lacerda Luiz Drude de , Ferreira Alexander Cesar , Borges Rebecca , Ward Raymond 
Published: December 2024

Abstract
The semiarid northeast coast of Brazil harbours just less than 44,300 ha of mangroves, 4% of Brazilian total. Notwithstanding this relatively small area, these forests have high ecological and economic importance, sustaining traditional fisheries and protecting biodiversity, including many threatened species. They present unique biogeochemical characteristics resulting in distinct ecosystem functioning compared to mangroves located in humid areas. Semiarid mangroves present lower aboveground biomass compared to humid region mangroves but show similar belowground biomass. Whereas mangrove soils in humid areas are strongly influenced by sulphate reduction, iron geochemistry is a primary driver of soil characteristics in semiarid mangrove soils, suggesting different responses to climate change drivers between them. Although legally protected, they have incurred continuous degradation due to regional drivers, mostly aquaculture and river damming, which differs from those in humid coast mangroves. Semiarid mangroves are also particularly sensitive to drivers associated with global climate change (high temperatures, reduced rainfall and sea level rise). These conditions occur at a global scale; however, the impacts are worsened by the natural conditions of semiarid coastlines, which already provide biologically stressful conditions for mangroves. This article compares the impacts of such drivers in semiarid mangroves with those of humid mangroves, focusing on their biogeochemical response and eventual rehabilitation.
Radical uncertainty and pragmatism: Threat perception and response
Authors: Stein Janice Gross 
Published: December 2024

Abstract
This article brings a pragmatic perspective to the analysis of threat perception in two important ways. First, as does the philosophical tradition of pragmatism, the article joins perception (or knowledge) together with response (action). Perception and response, knowledge and action, are inextricably linked as people learn through the creation of knowledge what is useful in the world. It is in this sense that pragmatists understand the perception and response to threats as evolved practices that are conjoined. Second, the paper explores threat perception and response under the condition of radical uncertainty. I explore the kinds of strategies leaders can use to respond to perceived threat in a context of radical uncertainty, the defining characteristic of contemporary world politics, and explore the advantages of pragmatic strategies that proceed to look for ‘what works in the world’ as provisional responses to perceived threats through iterative, ongoing experimental processes.
Under the shadow of occupation: cultural, archaeological, and military activities at Topkapı Palace during the armistice period, 1918–1923
Authors: Özlü Nilay 
Published: December 2024

AbstractThis article looks at Topkapı Palace as a showcase reflecting the changing cultural heritage policies of the Allies, as well as of the İstanbul and Ankara governments, during the occupation of İstanbul from 1918 to 1923. It analyzes the military, archaeological, and cultural facets of the occupation, focusing first on the military takeover of the Topkapı gardens, then on the French archaeological mission at the Seraglio, and finally on conflicts over the possession of the imperial treasures and sacred relics. Drawing on primary sources from Ottoman, Turkish, French, and British archives, memoirs, letters, newspapers, and visual material, this article explores the versatility of cultural heritage policies during the occupation and the entangled relations among various power groups, institutions, and actors. The military, strategic, cultural, and historical significance of the royal complex, together with its invaluable imperial collections, made the historic palace a place of rivalry and contestation, as well as deception and cooperation, among various agents and actors, including the Ottoman military and bureaucratic officials, local and foreign archaeologists, the dynastic family, the Interallied government, the occupation forces, and the Turkish resistance forces, ultimately reflecting the military and political empowerment of Ankara.
The role of processing goals in second language predictive processing
Authors: Kim Hyunwoo , Kim Kitaek , Kim Joonhee 
Published: December 2024

Abstract
This study investigates how second language (L2) learners engage in prediction based on their processing goals. While prediction is a prominent feature of human sentence comprehension in first–language speakers, it remains less understood when and how L2 learners engage in predictive processing. By conducting a visual–world eye–tracking experiment involving Chinese–speaking L2 learners of Korean, we tested the hypothesis that L2 learners determine whether to engage in prediction by evaluating the costs and benefits of anticipatory processing. The experiment specifically focused on the impact of a top–down comprehension goal for L2 learners’ predictive use of an honorific form in Korean by providing them with different types of task instruction. Our results indicated that all groups engaged in predictive processing in early and entire predictive regions. However, in the late predictive region, L2 learners presented with a prediction–oriented task, but not those with a simple comprehension task, actively generated expectations about the honorific status of an upcoming referent. These findings lend support to the utility account of L2 prediction, suggesting that L2 learners’ engagement in prediction depends on their current goals and strategies for processing efficiency.
Uterus Transplant: Bioethical and Biolegal Issues from Mexico
Authors: Calleja-Sordo Elisa Constanza , Medina-Arellano María de Jesús 
Published: December 2024

Abstract
Uterus transplants (UTx) provide women without a uterus the possibility of experiencing gestational motherhood. This paper delineates the complex bioethical landscape surrounding UTx, focusing on the critical aspects of informed consent, risk–benefit analysis, justice considerations, and the distinct challenges encountered by both donors and recipients. While not discussing UTx directly, John Harris’ seminal work, The Value of Life: An Introduction to Medical Ethics (1985) in its advocacy for reproductive freedom and informed consent provides an informative starting point for the discussion.
As an example, UTx is analyzed within the socio-political context of Mexico. The impact of the Mexican healthcare and legal systems on UTx procedures is discussed and the regulatory measures necessary to ensure that UTx is conducted ethically and equitably are outlined.
Psychosocial interventions for hoarding disorder: a systematic review
Authors: Twigger Daisy , Gregory James D. , Bowers Emma , Millar Josie F.A. 
Published: December 2024

Abstract

Introduction:
Hoarding disorder (HD) is primarily characterised by difficulties with discarding possessions. Evidence-based psychological interventions such as CBT have been found to be of benefit to people with HD. However, people with HD may receive a psychosocial intervention provided by other professions such as social workers or a multi-disciplinary team before receiving psychological therapy, if at all.

Objectives:
The aim of this systematic review is to evaluate psychosocial interventions for HD.

Method:
Searches were conducted on three databases (PsycInfo; MEDLINE; Embase) and grey literature, and the search strategy was designed to capture psychosocial interventions for adults with HD.

Results:
Studies (n=5) were included where the outcome was related to a psychosocial factors, such as fire safety, tenancy preservation and QoL. These psychosocial interventions show improvements in those with HD, with effect sizes ranging from d=0.86 to d=1.41.

Conclusions:
Despite the limited research on psychosocial interventions for HD, this systematic review suggests it is a promising area for further research in this area.

Key learning aims

(1)
To identify what psychosocial interventions are available for people experiencing hoarding difficulties.

(2)
To identify how available psychosocial interventions for hoarding difficulties are delivered and by whom.

(3)
To examine the effectiveness of psychosocial interventions for people experiencing hoarding difficulties.
New Generation Site and Estimated Propagation of Nonlinear Internal Waves Under Varying Background Stratification in the Northeastern East China Sea
Authors: Lee Seung‐Woo , Nam SungHyun , Noh Suyun 
Published: December 2024

AbstractThis study investigates the generation and propagation of nonlinear internal waves (NLIWs) in the northeastern East China Sea (ECS), focusing on the impact of time‐varying background stratification. Using satellite imagery and tide‐generating body force, 327 groups of NLIWs were identified from 93 MODIS images collected between 2015 and 2019 and classified into three distinct types based on their propagation directions—Type‐A (∼42%), Type‐B (∼38%), and Type‐C (∼20%)—each originating from different generation sites. Type‐B NLIWs were found to originate from a newly identified site near southwestern Fukue Island reported here for the first time, whereas Type‐A and Type‐C originated from the northern Okinawa Trough and southwestern Jeju Island, respectively. Seasonal variations in NLIW propagation speed using historical CTD data revealed an increase in the speed from winter to spring and fall, peaking in summer due to strong stratification. Although spatial distribution varied by season, propagation was generally faster in the eastern region than in the western region attributed to deeper thermoclines and higher density gradients. During field observation in May 2015, the observed NLIWs had an amplitude of 5–6 m, a characteristic width of 380–450 m, southwestward propagating directions, and a speed of ∼0.54 m s−1. An empirical model, used to track and predict these waves, confirmed their generation locations from southwestern Fukue Island (Type‐B) and indicated fast arrival speeds, influenced by time‐varying stratification conditions during the stratification period. These findings highlight the impacts of varying background conditions on NLIW propagation and would facilitate their prediction.
TIGAR coordinates senescence-associated secretory phenotype via lysosome repositioning and α-tubulin deacetylation
Authors: Nam Hae Yun , Park Seung-Ho , Lee Geun-Hee , Kim Eun-Young , Lee SangEun , Chang Hyo Won , Chang Eun-Ju , Choi Kyung-Chul , Kim Seong Who 
Published: December 2024

AbstractTP53-induced glycolysis and apoptosis regulator (TIGAR) regulates redox homeostasis and provides the intermediates necessary for cell growth by reducing the glycolytic rate. During cellular senescence, cells undergo metabolic rewiring towards the glycolytic pathway, along with the development of the senescence-associated secretory phenotype (SASP), also known as the secretome. We observed that TIGAR expression increased during replicative senescence following the in vitro expansion of human mesenchymal stromal cells (MSCs) and that TIGAR knockout (KO) decreased SASP factors and triggered premature senescence with decelerated progression. Additionally, TIGAR KO impaired flexible lysosomal movement to the perinuclear region and decreased the autophagic flux of MSCs. Research on the mechanism of lysosomal movement revealed that, while native senescent MSCs presented low levels of Ac-α-tubulin (lysine 40) and increased sirtuin 2 (SIRT2) activity compared with those in growing cells, TIGAR KO-MSCs maintained Ac-α-tubulin levels and exhibited decreased SIRT2 activity despite being in a senescent state. The overexpression of SIRT2 reduced Ac-α-tubulin as a protein target of SIRT2 and induced the positioning of lysosomes at the perinuclear region, restoring the cytokine secretion of TIGAR KO-MSCs. Furthermore, TIGAR expression was positively correlated with SIRT2 activity, indicating that TIGAR affects SIRT2 activity partly by modulating the NAD+ level. Thus, our study demonstrated that TIGAR provides a foundation that translates the regulation of energy metabolism into lysosome positioning, affecting the secretome for senescence development. Considering the functional value of the cell-secretome in aging-related diseases, these findings suggest the feasibility of TIGAR for the regulation of secretory phenotypes.
Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application
Authors: Chen Yang , Liang Rui , Li Yong , Jiang Lingli , Ma Di , Luo Qing , Song Guanbin 
Published: December 2024

AbstractThe dynamic regulation of chromatin accessibility is one of the prominent characteristics of eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which is multilevel compressed and access restricted. The remaining accessible loci are generally located in the euchromatin, which have less nucleosome occupancy and higher regulatory activity. The opening of chromatin is the most important prerequisite for DNA transcription, replication, and damage repair, which is regulated by genetic, epigenetic, environmental, and other factors, playing a vital role in multiple biological progresses. Currently, based on the susceptibility difference of occupied or free DNA to enzymatic cleavage, solubility, methylation, and transposition, there are many methods to detect chromatin accessibility both in bulk and single-cell level. Through combining with high-throughput sequencing, the genome-wide chromatin accessibility landscape of many tissues and cells types also have been constructed. The chromatin accessibility feature is distinct in different tissues and biological states. Research on the regulation network of chromatin accessibility is crucial for uncovering the secret of various biological processes. In this review, we comprehensively introduced the major functions and mechanisms of chromatin accessibility variation in different physiological and pathological processes, meanwhile, the targeted therapies based on chromatin dynamics regulation are also summarized.
Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system
Authors: Pedroni Andrea , Yilmaz Elanur , Del Vecchio Lisa , Bhattarai Prabesh , Vidal Inés Talaya , Dai Yu-Wen E. , Koutsogiannis Konstantinos , Kizil Caghan , Ampatzis Konstantinos 
Published: December 2024

Abstract
The proper functioning of the heart relies on the intricate interplay between the central nervous system and the local neuronal networks within the heart itself. While the central innervation of the heart has been extensively studied, the organization and functionality of the intracardiac nervous system (IcNS) remain largely unexplored. Here, we present a comprehensive taxonomy of the IcNS, utilizing single-cell RNA sequencing, anatomical studies, and electrophysiological techniques. Our findings reveal a diverse array of neuronal types within the IcNS, exceeding previous expectations. We identify a subset of neurons exhibiting characteristics akin to pacemaker/rhythmogenic neurons similar to those found in Central Pattern Generator networks of the central nervous system. Our results underscore the heterogeneity within the IcNS and its key role in regulating the heart’s rhythmic functionality. The classification and characterization of the IcNS presented here serve as a valuable resource for further exploration into the mechanisms underlying heart functionality and the pathophysiology of associated cardiac disorders.
Identification of rare disease genes as drivers of common diseases through tissue-specific gene regulatory networks
Authors: Bakker Olivier B. , Claringbould Annique , Westra Harm-Jan , Wiersma Henry , Boulogne Floranne , Võsa Urmo , Urzúa-Traslaviña Carlos G. , Mulcahy Symmons Sophie , Zidan Mahmoud M. M. , Sadler Marie C. , Kutalik Zoltán , Jonkers Iris H. , Franke Lude , Deelen Patrick 
Published: December 2024

AbstractGenetic variants identified through genome-wide association studies (GWAS) are typically non-coding, exerting small regulatory effects on downstream genes. However, which downstream genes are ultimately impacted and how they confer risk remains mostly unclear. By contrast, variants that cause rare Mendelian diseases are often coding and have a more direct impact on disease development. Here we demonstrate that common and rare genetic diseases can be linked by studying how common disease-associated variants influence gene co-expression in 57 different tissues and cell types. We implemented this method in a framework called Downstreamer and applied it to 88 GWAS traits. We find that predicted downstream “genes” are enriched with Mendelian disease genes, e.g. key genes for height are enriched for genes that cause skeletal abnormalities and Ehlers–Danlos syndromes. 78% of these key genes are located outside of GWAS loci, suggesting that they result from complex trans regulation rather than being impacted by disease-associated variants in cis. Based on our findings, we discuss the challenges in reconstructing gene regulatory networks and provide a roadmap to improve the identification of these highly connected genes linked to common traits and diseases.
A fish-friendly axial flow pump turns out to be eel safe, roach unfriendly and bream unsafe
Authors: Bruneel Stijn , Pauwels Ine S. , Broos Sarah , Vandamme Lore , Van Wichelen Jeroen , Coeck Johan , Toming Gert , Tuhtan Jeffrey A. , Buysse David 
Published: December 2024

AbstractAdditional and refurbished pumping stations are required to mitigate the intensifying occurrence of droughts and floodings. These installations negatively impact threatened freshwater fish populations due to the increased risk of injury and mortality when fish pass through them. Fish-friendly pumping installations have been proposed as a potential solution to reduce these risks. However, published assessments of these new types of pumps remains lacking, and the few available studies do not enable a cross-comparison with conventional pump types. The promising, yet understudied, Fairbank Nijhuis ‘fish-friendly’ axial flow pump has been assessed in previous works, however the results remain ambiguous due to low recapture rates, unconsidered parameters, fixed operating conditions, and the inability to identify the likely sources of injury and mortality. In this study, we address the limitations of previous works by implementing a standardized protocol for live fish in conjunction with passive barotrauma detection sensors. The major finding of this work is that safe passage of eel (100% survival) is confirmed, but that bream and roach had a much lower survival probability (24% and 70% survival respectively) than expected, albeit higher than for a conventional axial flow pump (roach survival: 13%). Furthermore, roach and bream passing at higher rpm suffered significantly higher mortalities. The impact of the impeller was found to be the most common source of severe injury for both pumps. These results are significant because they conclusively show that fish-friendly pumps may be considered safe for eel, but not for other endemic European fish species such as roach and bream.
Potential energy landscape formalism for quantum molecular liquids
Authors: Eltareb Ali , Zhou Yang , Lopez Gustavo E. , Giovambattista Nicolas 
Published: December 2024

AbstractThe potential energy landscape (PEL) formalism is a powerful tool within statistical mechanics to study the thermodynamic properties of classical low-temperature liquids and glasses. Recently, the PEL formalism has been extended to liquids/glasses that obey quantum mechanics, but applications have been limited to atomistic model liquids. In this work, we extend the PEL formalism to liquid/glassy water using path-integral molecular dynamics (PIMD) simulations, where nuclear quantum effects (NQE) are included. Our PIMD simulations, based on the q-TIP4P/F water model, show that the PEL of quantum water is both Gaussian and anharmonic. Importantly, the ring-polymers associated to the O/H atoms in the PIMD simulations, collapse at the local minima of the PEL (inherent structures, IS) for both liquid and glassy states. This allows us to calculate, analytically, the IS vibrational density of states (IS-VDOS) of the ring-polymer system using the IS-VDOS of classical water (obtained from classical MD simulations). The role of NQE on the structural properties of liquid/glassy water at various pressures are discussed in detail. Overall, our results demonstrate that the PEL formalism can effectively describe the behavior of molecular liquids at low temperatures and in the glass states, regardless of whether the liquid/glass obeys classical or quantum mechanics.
Sensitivity of mesoscale modeling to urban morphological feature inputs and implications for characterizing urban sustainability
Authors: Allen-Dumas Melissa R. , Sweet-Breu Levi T. , Brelsford Christa M. , Wang Linying , New Joshua R. , Bass Brett C. 
Published: December 2024

AbstractWe examine the differences in meteorological output from the Weather Research and Forecasting (WRF) model run at 270 m horizontal resolution using 10 m, 100 m and 1 km resolution 3D neighborhood morphological inputs and with no morphological inputs. We find that the spatial variability in temperature, humidity, and other meteorological variables across the city can vary with the resolution and the coverage of the 3D urban morphological input, and that larger differences occur between simulations run without 3D morphological input and those run with some type of 3D morphology. We also find that the inclusion of input-building-defined roughness length calculations would improve simulation results further. We show that these inputs produce different patterns of heat wave spatial heterogeneity across the city of Washington, DC. These findings suggest that understanding neighborhood level urban sustainability under extreme heat waves, especially for vulnerable neighborhoods, requires attention to the representation of surface terrain in numerical weather models.
Photocontrol of ferroelectricity in multiferroic BiFeO3 via structural modification coupled with photocarrier
Authors: Takubo Kou , Ono Atsushi , Ueno Shunsuke , Banu Samiran , Yu Hongwu , En-ya Kaito , Nishimori Ryota , Kuwahara Makoto , Asaka Toru , Maeda Kei , Ono Daiki , Ozawa Keita , Itoh Takuma , Shigematsu Kei , Azuma Masaki , Ishikawa Tadahiko , Okimoto Yoichi , Hada Masaki , Koshihara Shin-ya 
Published: December 2024

AbstractUltrafast control of ferroelectricity and magnetism by light is essential for future development in multiple functioning devices. Here, we demonstrate that the intense and ultrafast photo-modulation of the electric dipole can be realized by photocarrier injection into a multiferroic BiFeO3 thin film using optical pump-probe and second harmonic generation measurements. Results of ultrafast electron diffraction with <100 fs time resolution and theoretical study reveal that the localized photocarrier strongly couples with the lattice structure and becomes the origin for the observed sudden change in the electric dipole. In addition, the subsequent structural dynamics involve a strong oscillation with a frequency of ~3.3 THz despite a poor structural symmetry change. Based on a theoretical calculation, this oscillation can be attributed to an unexpectedly softened new phonon mode generated by mixing essential two phonon modes governing the multiferroic (ferroelectric and antiferromagnetic) nature of BiFeO3 in the ground state due to strong coupling with a localized photocarrier. The comprehensive study shows that injection of the localized photocarrier strongly coupled with the lattice vibration mode can simultaneously realize the ultrafast switching of electric dipoles and magnetic interaction at once, even at room temperature, without modifying the long-range lattice structure.