bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life history evolution and phenotypic plasticity in parasitic eyebrights (Euphrasia, Orobanchaceae)
Authors: Twyford Alex D. , Frachon Natacha , Wong Edgar L. Y. , Metherell Chris , Brown Max R. 
Published: July 2018

ABSTRACTPremise of the studyParasite lifetime reproductive success is determined by both genetic variation and phenotypically plastic life history traits that respond to host quality and external environment. Here, we use the generalist parasitic plant genus Euphrasia to investigate life history trait variation, in particular whether there is a trade-off between growth and reproduction, and how life history traits are affected by host quality.MethodsWe perform a common garden experiment to evaluate life history trait differences between eleven Euphrasia taxa grown on a common host, document phenotypic plasticity when a single Euphrasia species is grown on eight different hosts, and relate our observations to trait differences recorded in the wild.Key resultsEuphrasia exhibit a range of life history strategies that differ between species that transition rapidly to flower at the expense of early season growth, and those that invest in vegetative growth and delay flowering. Many life history traits show extensive phenotypic plasticity in response to host quality and demonstrate the costs of attaching to a low-quality host.ConclusionsCommon garden experiments reveal trait differences between taxonomically complex Euphrasia species that are characterised by postglacial speciation and hybridisation. Our experiments suggest life history strategies in this generalist parasitic plant genus are the product of natural selection on traits related to growth and flowering. However, host quality may be a primary determinant of lifetime reproductive success.
Flow stimuli reveal ecologically-appropriate responses in mouse visual cortex
Authors: Dyballa Luciano , Hoseini Mahmood S. , Dadarlat Maria C. , Zucker Steven W. , Stryker Michael P. 
Published: July 2018

AbstractAssessments of the mouse visual system based on spatial frequency analysis imply that its visual capacity is low, with few neurons responding to spatial frequencies greater than 0.5 cycles/degree. However, visually-mediated behaviors, such as prey capture, suggest that the mouse visual system is more precise. We introduce a new stimulus class—visual flow patterns—that is more like what the mouse would encounter in the natural world than are sine-wave gratings but is more tractable for analysis than are natural images. We used 128-site silicon microelectrodes to measure the simultaneous responses of single neurons in the primary visual cortex (V1) of alert mice. While holding temporal-frequency content fixed, we explored a class of drifting patterns of black or white dots that have energy only at higher spatial frequencies. These flow stimuli evoke strong visually-mediated responses well beyond those predicted by spatial frequency analysis. Flow responses predominate in higher spatial-frequency ranges (0.15–1.6 cycles/degree); many are orientation- or direction-selective; and flow responses of many neurons depend strongly on sign of contrast. Many cells exhibit distributed responses across our stimulus ensemble. Together, these results challenge conventional linear approaches to visual processing and expand our understanding of the mouse’s visual capacity to behaviorally-relevant ranges.Significance StatementThe visual system of the mouse is now widely studied as a model for development and disease in humans. Studies of its primary visual cortex (V1) using conventional grating stimuli to construct linear-nonlinear receptive fields suggest that the mouse must have very poor vision. Using novel stimuli resembling the flow of images across the retina as the mouse moves through the grass, we find that most V1 neurons respond reliably to very much finer details of the visual scene than previously believed. Our findings suggest that the conventional notion of a unique receptive field does not capture the operation of the neural network in mouse V1.
Dynamics of the Ghrelin/Growth Hormone Secretagogue Receptor System in the Human Heart Before and After Cardiac Transplantation
Authors: Sullivan Rebecca , Randhawa Varinder K , Stokes Anne , Wu Derek , Lalonde Tyler , Kiaii Bob , Luyt Leonard , Wisenberg Gerald , Dhanvantari Savita 
Published: July 2018

AbstractBackgroundCurrently, the early pre-clinical detection of left ventricular (LV) dysfunction is difficult as biomarkers are not specific for the cardiomyopathic process. The underlying molecular mechanisms leading to heart failure remain elusive, highlighting the need for identification of cardiac-specific markers. The growth hormone secretagogue receptor (GHSR) and its ligand ghrelin are present in cardiac tissue and are known to contribute to myocardial energetics. Here, we examined tissue ghrelin-GHSR levels as specific markers of cardiac dysfunction in patients who underwent cardiac transplantation.Methods and ResultsSamples of cardiac tissue were obtained from 10 cardiac transplant patients at the time of organ harvesting, and during serial post-transplant biopsies. Quantitative fluorescence microscopy using a novel fluorescent ghrelin analog was used to measure levels of GHSR, and immunofluorescence was used to measure levels of ghrelin, b-type natriuretic peptide (BNP) and tissue markers of cardiomyocyte contractility and growth. GHSR and ghrelin expression levels were highly variable in the explanted heart, less in the grafted heart biopsies. GHSR and ghrelin were strongly positively correlated, and both markers were negatively correlated with LV ejection fraction. Ghrelin had stronger positive correlations than BNP with the signaling markers for contractility and growth.ConclusionsThese data suggest that GHSR-ghrelin have potential use as an integrated marker of cardiac dysfunction. Interestingly, tissue ghrelin appeared to be a more sensitive indicator than BNP to the biochemical processes that are characteristic of heart failure. This work allows for further use of ghrelin-GHSR to interrogate cardiac-specific biochemical mechanisms in pre-clinical stages of HF.PrecisThis study shows the relationships between GHSR, ghrelin, and signaling molecules with relation to heart function in human heart failure with tissue from diseased heart and healthy heart biopsies.
The limits of long-term selection against Neandertal introgression
Authors: Petr Martin , Pääbo Svante , Kelso Janet , Vernot Benjamin 
Published: July 2018

AbstractSeveral studies have suggested that introgressed Neandertal DNA was subjected to negative selection in modern humans due to deleterious alleles that had accumulated in the Neandertals after they split from the modern human lineage. A striking observation in support of this is an apparent monotonic decline in Neandertal ancestry observed in modern humans in Europe over the past 45 thousand years. Here we show that this apparent decline is an artifact caused by gene flow between West Eurasians and Africans, which is not taken into account by statistics previously used to estimate Neandertal ancestry. When applying a more robust statistic that takes advantage of two high-coverage Neandertal genomes, we find no evidence for a change in Neandertal ancestry in Western Europe over the past 45 thousand years. We use whole-genome simulations of selection and introgression to investigate a wide range of model parameters, and find that negative selection is not expected to cause a significant long-term decline in genome-wide Neandertal ancestry. Nevertheless, these models recapitulate previously observed signals of selection against Neandertal alleles, in particular a depletion of Neandertal ancestry in conserved genomic regions that are likely to be of functional importance. Thus, we find that negative selection against Neandertal ancestry has not played as strong a role in recent human evolution as had previously been assumed.
Trajectory planning for mini unmanned helicopter in obstacle and windy environments
Authors: Xiang Jinwu , Shen Tong , Li Daochun 
Published: July 2018

Purpose
Obstacle and wind field are common environmental factors for mini unmanned helicopter (MUH) flight. This paper aims to develop a trajectory planning approach guiding MUH to avoid static and dynamic obstacles and to fly in steady uniform or boundary-layer wind field.

Design/methodology/approach
An optimal control model including a nonlinear flight dynamics model and a cubic obstacle model is established for MUH trajectory planning. Radau pseudospectral method is used to generate the optimal trajectory.

Findings
The approach can plan reasonable obstacle-avoiding trajectories in obstacle and windy environments. The simulation results show that high-speed wind fields increase the flight time and fluctuation of control inputs. If boundary-layer wind field exists, the trajectory deforms significantly and gets closer to the ground to escape from the strong wind.

Originality/value
The key innovations in this paper include a cubic obstacle model which is straightforward and practical for trajectory planning and MUH trajectory planning in steady uniform wind field and boundary-layer wind field. This study provides an efficient solution to the trajectory planning for MUH in obstacle and windy environments.
A shiitake mushroom extract as a viable alternative to NaCl for a reduction in sodium in beef burgers
Authors: Mattar Thayana Vilela , Gonçalves Carla Saraiva , Pereira Rafaela Corrêa , Faria Michelle Aparecida , de Souza Vanessa Rios , Carneiro João de Deus Souza 
Published: July 2018

Purpose
The purpose of this paper is to evaluate a shiitake mushroom extract as a potential natural taste enhancer in low-sodium beef burgers by means of sensorial and physico-chemical assays because nowadays there is a trend in the market for the development of clean-label products.

Design/methodology/approach
Ten formulations of beef burgers were developed, varying in the percentage reduction in NaCl (0-75 per cent) and mushroom water extracts (obtained from a 5, 12.5, or 20 per cent mushroom homogenate). Sensory characterisation was performed by time-intensity (TI) and acceptance tests. In addition, physico-chemical analyses (pH, yield, shrinkage, shear force, and colour) were conducted.

Findings
Extracts obtained from 5, 12.5, or 20 per cent mushroom homogenate (E1, E2, and E3, respectively) did not enhance the salty taste in formulations with a 0 or 75 per cent reduction in NaCl. In formulations with a 50 per cent reduction in NaCl, all the extracts enhanced salinity perception, with E3 being the most effective. E3 also increased acceptance of colour, aroma, texture, flavour, and overall perception, although it caused changes in some physico-chemical characteristics (pH, yield, shrinkage, shear force, and colour).

Originality/value
The shiitake mushroom extract is a natural ingredient with a potential to serve as a taste enhancer in meat and other food products, for the purpose of reducing sodium content without compromising sensory acceptability. Therefore, this extract will enable the development of healthier products (owing to a reduction in sodium) with preserved sensory quality and will meet consumers’ requirements for the minimal use of chemical additives in food.
Linking strategic management accounting and quality management systems
Authors: Sedevich-Fons Leonardo 
Published: July 2018

Purpose
Quality management is gradually becoming an area of interest among management accounting practitioners and scholars because of its significant effects on performance and increasing adoption by organizations. Therefore, the purpose of this paper is to explore the relationships between these two broad disciplines and provide guidelines for their joint consideration.

Design/methodology/approach
Two specific management innovations are analyzed in detail: strategic management accounting (SMA) and ISO 9000 quality management system (QMS). Such an analysis includes a literature review of both frameworks, the identification of benefits associated with their simultaneous application and the design of a comprehensive model integrating their individual principles.

Findings
It is concluded that these management schemes are compatible and complementary from a theoretical standpoint; and that, therefore, their combined implementation might help organizations improve overall performance. It is also argued here that their use in conjunction could facilitate the spread of SMA techniques and the full exploitation of QMSs.

Originality/value
A new management system proposing the incorporation of SMA tools into traditional QMSs is introduced, and some recommendations for its practical use are presented.
A novel framework for owner driven reconstruction projects to enhance disaster resilience in the long term
Authors: Vahanvati Mittul 
Published: July 2018

PurposePost-disaster reconstruction poses a double-edged sword to its implementers as it demands addressing survivors’ need for speed as well as meeting the growing expectation to trigger resilience. While an owner-driven housing reconstruction (ODHR), inter-disciplinary and long-term approach has been promoted internationally; however, there is limited research focussed on the long-term impacts (>10 years after a disaster) of ODHR. Furthermore, there is no one accepted framework for practitioners to guide through the process of ODHR projects to carve pathways for disaster resilience. The purpose of this paper is to assimilate findings—contingent and generalisable—into a novel framework for future change in practice.Design/methodology/approachThis paper deployed a mixed methods methodology with a comparative case study research method. Two case study projects were from the Indian state of Gujarat, 13 years after the 2001 earthquake and the other two from Bihar, 6 years since the 2008 Kosi river floods. Due to multi-disciplinary nature of research, empirical data collection relied on a mix of social sciences methods including 80 semi-structured interviews, and architectural research methods including the visual analysis of photographs and sketches. Three sample groups of agency members, beneficiaries and non-beneficiaries were purposively selected. Thematic content analysis was used for the data analysis.FindingsThe paper provides empirical insights on how ODHR projects in Indian states of Gujarat and Bihar succeeded at enhancing disaster resilience of communities. It suggests that the civil society organisations acted as “enablers” at four stages: envisioning strategically based on systemic understanding, building soft assets including community trust and dignity for social mobilisation prior to, proposing minor modifications to construction technology for its multi-hazard safety as well as cultural relevance, and sustaining capacity building efforts beyond reconstruction completion or beyond one project life-cycle.Research limitations/implicationsThe author of this paper cautions that the spiral framework needs further development to make it flexibility and customisable to suit the specifics of a particular context.Originality/valueThe implications of the findings discussed in this paper are primarily for practitioners involved in disaster recovery and development sector. Since prevailing models or frameworks neither incorporate multi-disciplinary approach (demanded by socio-ecological systems resilience concept), nor represent project scale, a novel, four-pronged framework for ODHR has been proposed in this paper for strategic success. The framework has been illustrated in spiral and tabular forms, and has been kept abstract to provide practitioners the much-needed flexibility for adapting it to suit the specifics of a particular context.
Resource levelling optimization model considering float loss impact
Authors: El-Sayegh Sameh 
Published: July 2018

Purpose
The purpose of this paper is to propose a Non-Linear Integer Programming (NLIP) model that solves the resource leveling problem while reducing the negative effect of the total float loss on risk.

Design/methodology/approach
An NLIP model is formulated to solve the resource leveling optimization problem incorporating float loss cost (FLC). The proposed model is implemented using “What’s Best solver” for Excel. The FLC is calculated using the float commodity approach. An example is solved using the proposed model in order to illustrate its applicability. Sensitivity analysis is also performed.

Findings
The results confirmed that resource leveling reduces the available float of non-critical activities; decreases schedule flexibility and reduces the probability of project completion. The probability of timely completion dropped from 50 percent (for the normal schedule with 32 resource fluctuations) to 13.5 percent for leveled resources with zero fluctuations. Using the proposed method, the number of resource fluctuations is 8 but the probability of completing the project on time improved to 20 percent.

Practical implications
The proposed model allows project managers to exercise new trade-offs between resource leveling and schedule flexibility which will ultimately improve the chances of successful project delivery.

Originality/value
Resource leveling techniques result in reducing the available total float for the non-critical activities. Existing methods focus on moving noncritical activities within their available float and ignore the impact of the resulting float loss. This reduces the schedule flexibility and increase the risk of project delays. The proposed model incorporates the FLC into the resource leveling optimization problem resulting in more efficient schedules with improved resource utilization while keeping some schedule flexibility.
The Grow parenting program: demonstrating proof of concept
Authors: Chesnut Ryan , DiNallo Jennifer M. , Czymoniewicz-Klippel Melina T. , Perkins Daniel F. 
Published: July 2018

PurposeParent-focused interventions (PFIs) are a promising method for supporting parents and promoting children’s well-being. Few PFIs in the USA, however, include physical health promotion content and are universal programs. The purpose of this paper is to describe a universal health-promoting PFI for parents of elementary school-aged children and demonstrate proof of concept.Design/methodology/approachThe program emphasizes positive parenting practices, stress management skills and physical health promotion strategies and recommendations, and is part of a larger initiative that includes a continuum of universal, developmentally appropriate, health-promoting PFIs for civilian and military parents. The program was implemented at two community sites in rural Pennsylvania with 20 civilian parents completing pretests and posttests. Study measures assessed parenting, stress and stress management and physical health promotion related outcomes.FindingsParents reported decreases in suboptimal discipline and feeding practices, stress and child internalizing behavior. They also reported increases in their sense of control in managing child behavior, coping socialization, child’s outdoor playtime and health recommendations met.Research limitations/implicationsWhile these preliminary findings may not be generalizable, they serve as proof of concept, which suggests that more rigorous research on the program is warranted.Practical implicationsImplementing a universal, health-promoting PFI within the USA is viable and has the potential to impact multiple short-term outcomes.Originality/valueParents are among their child’s earliest and most influential educators, and this study lends further support to their role as health educators. Given the significant public health benefits of holistically promoting child health, the time has come for universal PFIs to begin including physical health promotion content.
Awareness and support: students’ views about the prevention of sexual assault on UK campuses
Authors: Camp Sarah-Jayne , Sherlock-Smith Anna C. , Davies Emma L. 
Published: July 2018

Purpose
Sexual assault is prevalent on UK University campuses, and prevention efforts are being increased. However, at present there is limited evidence about UK students’ attitudes towards sexual assault prevention and what they think should be done to effectively address the issue. The purpose of this paper is to explore these views to provide a foundation for the development of a new intervention.

Design/methodology/approach
A cross-sectional anonymous online survey was completed by 515 students (73 per cent women; M age: 21.56; 79 per cent heterosexual; and 82.9 per cent white). There were quantitative questions about experiences of sexual assault, attitudes towards sexual consent and victim blaming. Qualitative data were collected regarding participants’ views on what universities should do to target sexual assault.

Findings
In line with previous studies, the authors found evidence of commonplace and normalised sexual assault behaviours. Women had more positive attitudes towards explicit consent than men, and were less likely to blame victims of sexual assault who had been drinking. Consent behaviour was predicted by positive views towards consent and lower levels of blaming. Themes relating to “awareness”, “attitudes”, “environment” and “opposition” were identified in the qualitative data.

Practical implications
Findings highlight the importance of engaging with students to develop effective prevention measures. Students are likely to find university-led prevention strategies acceptable, but this topic needs to be addressed in the context of the prevailing culture, which may provide an environment where certain behaviours are tolerated. New prevention programmes need to treat the issue as one that is relevant to all students and not just target men as perpetrators and women as victims. Such strategies need to do more than treat this as an isolated issue, to which the solution is re-education about the meaning of consent.

Originality/value
There is at present a lack of research evidence about UK students’ views on sexual assault prevention. This exploratory survey highlights areas for consideration when developing new interventions.
#CondomEmoji
Authors: Ridlo Ilham Akhsanu , Zein Rizqy Amelia 
Published: July 2018

Purpose
The purpose of this paper is to explore participants’ attitudes and receptivity to a #CondomEmoji campaign insofar as investigating whether attitudes and receptivity were important predictors for brand impression and intention to buy.

Design/methodology/approach
This study involved 206 research participants who live in Jakarta and Surabaya and who answered online questionnaires to measure attitudes, receptivity to #CondomEmoji advertising, brand impression and intention to buy condoms. Questionnaires were circulated on several social media platforms and instant messaging apps. The participants were asked to watch the #CondomEmoji advertising video before proceeding to fill out the questionnaires.

Findings
Research findings suggested that participants mostly held negative attitudes and receptivity to the campaign. Non-sexually active participants were more likely to perceive the advertising as offensive. Attitudes and receptivity were good predictors for brand impression, yet attitude was not significantly attributed to intention to buy condoms. The result was stronger in sexually active participants.

Research limitations/implications
Non-sexually active young people need to be more informed about healthy sexual behavior so that they would not feel embarrassed to discuss and ask about sexual behavior. A socially acceptable condom-use advertising campaign needs to be conducted to lessen the resistance of conservative audiences.

Originality/value
This paper offers an insight into how conservative audiences may respond to social-media-based campaign of safer sex.