bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibiotic Therapy for ESBL and NDM producing Escherichia coli and Klebsiella pneumoniae isolates in a Tertiary Care Center
Authors: BORAH Vedant Vikrom , BAİSHYA Mrinal Kumar , SAİKİA Kandarpa Kr 
Published: December 2018

Objective: Antibiotic resistance is a global phenomenon wherein
physicians face the most challenging decision to make for the right kind of
drug, and its combinations, to tackle the ever growing ESBL and NDM on
pathogens. The aim of the study is to understand outcome of hospitalized
patients undergoing antibiotic therapy for bacterial infections. These patients
are from Kamrup District of Assam, India.

Materials
and methods: A total of 185 clinical isolates of Escherichia coli and Klebsiella
pneumoniae were collected from hospitalized patients of a tertiary care
centre presenting symptoms of infection. Upon biochemical identification, their
antibiotic susceptibility were assessed; isolates resistant to 3rd or 4th
generation cephalosporins or carbapenem were phenotypically and genotypically
determined for the production of extended spectrum β-lactamase (ESBL) and
carbapenemase. PCR was carried out for CTX-M, TEM, SHV, OXA-48 and New Delhi
Metallo-β-lactamase (NDM).

Results:
Bacterial infection is ubiquitous among male and female patients, with high
isolation rate of Escherichia coli
among female patients with urinary infection. The highest resistance against E. coli isolates was nalidixic acid
(82.9%; p≤0.005) and cefixime (81.4%; p≤0.005). The highest resistance against K. pneumoniae was cefotaxime (77.7%;
p≤0.005) and ceftazidime (73%; p≤0.005). Imipenem was the most effective
antibiotic while ertapenem was the least. Antibiotic therapy included
piperacillin (alone or in combination with tazobactam) for both E. coli and K. pneumoniae infections.

Conclusions: Ceftriaxone, amikacin, cefepime, ceftriazone and
imipenem were chosen as treatment options; isolates showed intermediate to
negligible resistance to these drugs. Tigecycline was administered to patients
infected with NDM producing pathogens. &nbsp;J Microbiol Infect Dis 2018; 8(4): 153-157.
Papular-purpuric Gloves and Socks Syndrome in a 46-year-old Man with Mycoplasma pneumoniae Respiratory Disease
Authors: JANKOVİC Jelena V. , PESUT Dragica P. 
Published: December 2018

Mycoplasma pneumoniae is a cause of upper and lower respiratory disease,
predominantly in children and young. Dermatologic manifestations of the
infection occur in 1-5% of the cases, most commonly as Stevens–Johnson Syndrome
and Erythema Multiforme. We present a 46-year-old previously healthy man heavy
smoker, who was admitted due to fatigue, chest pain, cough, and fever that
appeared seven days earlier. He was diagnosed pleuro-pneumonia caused by Mycoplasma pneumoniae. Apart from
bicytopenia as toxic extrapulmonary manifestation of the infection, he
developed a relatively novel pruritic
dermatosis - papular-purpuric gloves and socks syndrome (PPGSS). Under antibiotic treatment, disease had
favorable outcome. In the cases of PPGSS without known etiologic agent, testing for Mycoplasma pneumoniae might be useful to
reveal etiology of the syndrome, especially in adult subjects. Some of the known constitutional symptoms of PPGSS
such as fever and fatigue, may also belong to the co-existing viral or
bacterial infection. &nbsp;J Microbiol Infect Dis 2018; 8(4):158-161
Melioidosis: An unusual presentation as mycotic pseudoaneurysm of Left Superficial Femoral Artery
Authors: HARİSON Sarin J. , BHAT U. Pratibha , RAİ Rekha 
Published: December 2018

Melioidosis
is a potentially fatal infectious disease usually seen in, but not restricted
to the tropical areas of the world. Burkholderia
pseudomallei, a soil saprophytic bacterium are the causative agent. It can
produce latent infection and reactivate many years after initial exposure and
can have varied clinical presentations. Here we put forward an unusual yet
successfully treated case of melioidosis presenting as mycotic pseudoaneurysm
of superficial femoral artery. A 62 year old male patient came with a one and a
half month old history of swelling and pain in the left thigh. Culture of blood
and pus samples from the patient yielded Burkholderia
pseudomallei. Combinations of surgical and medical management lead to a
good outcome in the patient. J Microbiol
Infect Dis 2018; 8(4):162-164.
Gastric Cancer Patients Receiving Maintenance Hemodialysis After Surgery With and Without Postoperative Chemotherapy: A Case Series of 6
Authors: Ito Tomoaki , Maekawa Hiroshi , Sakurada Mutsumi , Orita Hajime , Kushida Tomoyuki , Mizuguchi Konomi , Sato Koichi 
Published: December 2018

Background:The management of gastric cancer patients who received gastrectomy and/or postoperative chemotherapy is of high importance. However, the safety and efficacy of chemotherapy in hemodialysis patients have not been established. In this study, we report 6 cases of hemodialysis patients who underwent gastrectomy for gastric cancer.Case Presentation:The presented cases included 5 men and 1 woman, with a mean age of 66.3 years (range, 59–74 years). All patients underwent standard laparotomy, with 3 of 6 patients (50%) experiencing postoperative complications. Three patients who did not experience any postoperative complications could receive subsequent chemotherapy. S-1 chemotherapy regimen and uracil and tegafur chemotherapy regimen were administered to 1 and 2 patients, respectively. These 3 patients did not experience any chemotherapy-related side effects. Among the 4 patients who received a diagnosis of pathologic stages II to III, 2 patients treated with postoperative chemotherapy achieved better prognoses than those who did not receive chemotherapy (mean, 25.5 versus 5.0 months).Discussion and Conclusion:Hemodialysis patients with gastric cancer who received gastrectomy exhibited a high morbidity rate. Postoperative chemotherapy can be performed immediately after surgery in patients who do not experience postoperative complications. S-1 regimen and uracil and tegafur regimen could be administered safely in hemodialysis patients. Postoperative chemotherapy may lead to a good prognosis in gastric cancer patients receiving hemodialysis.
Repair of Saphenofemoral Transition: Reşat Operation for Patients With Venous Reflux
Authors: Alat Ilker 
Published: December 2018

Objective:
To develop a new solution superior to the current surgical interventions in patients with venous reflux in the great saphenous vein (GSV).

Materials and Methods:
Patients with the symptoms of venous incompetence in their legs like pain, edema, and cramp were also examined with color Doppler ultrasonography (CDU). One hundred ninety-one extremities with venous reflux at the saphenofemoral transition (SFT) were subjected to surgery over 8 years. A newly designed operation, the Reşat operation, was performed in all of the patients. The Reşat Operation was performed only in the patients with continuous reflux at their saphenofemoral transition during the entire Valsalva maneuver. The follow-up time spanned more than 8 years. The patients' complaints, physical examinations, and CDU findings were evaluated.

Results:
All of the patients had continuous reflux at the SFT for the duration of the entire Valsalva maneuver preoperatively. However, 67.88% of the patients had no reflux postoperatively (P &lt; 0.001). Additionally, 95.76% of the patients recovered to different degrees in the early postoperative period ultrasonographically (P &lt; 0.001). All of the patients reported being satisfied with the result in the early postoperative period (P &lt; 0.001). In the late postoperative period, although the CDU reports of some patients showed reflux at the GSV, no patient complained about their condition.

Conclusion:
The Reşat operation is a well-tolerated operation and reconstitutes the saphenofemoral transitions successfully. Its early and late postoperative results are satisfactory. The Reşat operation should be the first-choice surgical treatment in patients with venous reflux at the saphenofemoral transition.
Predictors of High-Output Stoma After Low Anterior Resection With Diverting Ileostomy for Rectal Cancer
Authors: Pak Jongsung , Uemura Mamoru , Fukuda Yasunari , Miyake Masakazu , Ikeda Masataka , Nishikawa Kazuhiro , Miyamoto Atsushi , Hirao Motohiro , Nakamori Shoji , Sekimoto Mitsugu 
Published: December 2018

Background:The aim of this study was to identify predictors of high-output stoma (HOS) after low anterior resection (LAR) with diverting ileostomy for rectal cancer.Methods:The medical records of 60 patients who underwent LAR with diverting ileostomy for rectal cancer between 2012 and 2015 were reviewed. HOS was defined as ileostomy output greater than 1500 mL per 24 hours. Patient and surgical characteristics and patient laboratory data were examined to assess for predictors of HOS using univariate and multivariate logistic regression.Results:The incidence of HOS was 43.3% (26/60). In univariate analysis, age ≥ 70 years, diabetes mellitus (DM), preoperative albumin level ≤ 4.0 g/dL, and preoperative serum hemoglobin level ≤ 12 g/dL were significantly associated with HOS. Multivariate analysis identified DM (odds ratio, 9.74; 95% confidence interval, 1.86–77.3) as an independent predictor of HOS.Conclusions:DM might be a predictor of HOS in patients undergoing LAR with diverting ileostomy for rectal cancer.
Natural Concurrent Infection of Vibrio harveyi and V. alginolyticus in Cultured Hybrid Groupers in Malaysia
Authors: Mohamad Nurliyana , Mohd Roseli Fauzul Aidil , Azmai Mohammad Noor Amal , Saad Mohd Zamri , Md Yasin Ina Salwany , Zulkiply Nor Amalina , Nasruddin Nurrul Shaqinah 
Published: December 2018

Abstract
In September 2016, a marine fish farm operator in Selangor, Malaysia, reported a disease outbreak affecting juvenile hybrid groupers (Camouflage Grouper Epinephelus polyphekadion × Tiger Grouper E. fuscoguttatus). The average daily mortality was 120 fish, resulting in a cumulative mortality rate of 29% within 10 d. The affected hybrid groupers displayed lethargy, excessive mucus production, rotten fins, congestion of livers and kidneys, and enlargement of spleens. Microscopically, general congestion of the brains and internal organs was evident. Vibrio harveyi and V. alginolyticus were successfully isolated from the diseased fish. The isolated pathogens were found to be sensitive to oxytetracycline and tetracycline, but resistant towards ampicillin and vancomycin. Experimental infections using the isolated V. harveyi (108 CFU/mL), V. alginolyticus (108 CFU/mL), and concurrent infection by V. harveyi (108 CFU/mL) and V. alginolyticus (108 CFU/mL) in juvenile Asian Seabass Lates calcarifer resulted in 60, 100, and 100% mortality, respectively, within 240 h postinfection. The experimentally infected Asian Seabass demonstrated similar clinical signs and histopathological changes as the naturally infected hybrid groupers. However, concurrently infected fish demonstrated severe clinical signs and histopathological changes compared with single infections. These results suggest that both isolates of Vibrio are pathogenic to fish and responsible for the disease outbreak. However, concurrent infection involving V. alginolyticus and V. harveyi leads to a more devastating impact to the cultured fish. This is the first report of concurrent Vibrio infection in cultured marine fish in Malaysia.
Sensorimotor plasticity after spinal cord injury: a longitudinal and translational study
Authors: Jutzeler Catherine R. , Streijger Femke , Aguilar Juan , Shortt Katelyn , Manouchehri Neda , Okon Elena , Hupp Markus , Curt Armin , Kwon Brian K. , Kramer John L. K. 
Published: December 2018

AbstractObjectiveThe objective was to track and compare the progression of neuroplastic changes in a large animal model and humans with spinal cord injury.MethodsA total of 37 individuals with acute traumatic spinal cord injury were followed over time (1, 3, 6, and 12 months post‐injury) with repeated neurophysiological assessments. Somatosensory and motor evoked potentials were recorded in the upper extremities above the level of injury. In a reverse‐translational approach, similar neurophysiological techniques were examined in a porcine model of thoracic spinal cord injury. Twelve Yucatan mini‐pigs underwent a contusive spinal cord injury at T10 and tracked with somatosensory and motor evoked potentials assessments in the fore‐ and hind limbs pre‐ (baseline, post‐laminectomy) and post‐injury (10 min, 3 h, 12 weeks).ResultsIn both humans and pigs, the sensory responses in the cranial coordinates of upper extremities/forelimbs progressively increased from immediately post‐injury to later time points. Motor responses in the forelimbs increased immediately after experimental injury in pigs, remaining elevated at 12 weeks. In humans, motor evoked potentials were significantly higher at 1‐month (and remained so at 1 year) compared to normative values.ConclusionsDespite notable differences between experimental models and the human condition, the brain's response to spinal cord injury is remarkably similar between humans and pigs. Our findings further underscore the utility of this large animal model in translational spinal cord injury research.
Longitudinal Occurrence and Predictors of Patient‐Provider Discordance Between Global Assessments of Disease Activity in Rheumatoid Arthritis: A Case–Control Study
Authors: Challa Divya N. V. , Kvrgic Zoran , Crowson Cynthia S. , Matteson Eric L. , Mason Thomas G. , Michet Clement J. , Schaffer Daniel E. , Wright Kerry A. , Davis John M. 
Published: December 2018

ObjectiveTo identify longitudinal predictors of discordance between patients with rheumatoid arthritis (RA) and their health care providers, where patient global assessment of disease activity is substantially higher than provider global assessment.MethodsThis retrospective case–control study included 102 cases with positive discordance (i.e., ≥25 mm between patient and provider global assessments) and 102 controls without discordance who were matched for age, sex, RA duration, and Clinical Disease Activity Index (CDAI) score. Data were collected at the baseline visit (date of diagnosis or earliest available visit), the index visit (participation in a previous cross‐sectional study), and at up to 11 additional visits before the index visit. Data included patient characteristics, disease activity measures, Disease Activity Score in 28 joints (3‐variable) using the C‐reactive protein level (DAS28‐CRP), and medications. Data were analyzed by using linear and logistic regression models with smoothing splines for nonlinear trends.ResultsOverall, the mean age was 63 years, 75% of patients were female, and the mean RA duration was 10 years. Compared with controls, cases had higher rates of discordant visits during the 4 years before the index visit, and they had a higher CDAI score and DAS28‐CRP earlier in the disease course. Cases more frequently had antinuclear antibodies, nonerosive disease, prior depression, or prior use of antidepressants or fibromyalgia medications. Disease‐modifying medication use was not different between cases and controls.ConclusionThe findings inform new hypotheses about the relationships of disease activity and antinuclear antibodies to the later occurrence of positive discordance among patients with RA.
Tandem Cyclization−Annulation of α‐Acidic Isocyanides with 2‐Methyleneaminochalcones: Synthesis of Pyrrolo[2,3‐c]quinoline Derivatives
Authors: Dong Jinhuan , Wang Xin , Shi Hui , Wang Lei , Hu Zhongyan , Li Yifei , Xu Xianxiu 
Published: December 2018

AbstractTandem cyclization‐annulation of tosylmethyl isocyanide and isocyanoacetate with 2‐methyleneaminochalcones as aza‐1,5‐dielectrophiles has been successfully developed. These domino transformations feature simultaneous formation of three bonds and two rings in a single operation, and represent novel protocols for the expedient synthesis of both aromatic and partially aromatic pyrrolo[2,3‐c]quinoline derivatives from readily available precursors under metal‐free conditions. Notably, tetrahydro‐3H‐pyrrolo[2,3‐c]quinolones that bear three adjacent stereocenters were obtained in a highly diastereoselective manner.magnified image
Access to CF3‐Containing Cyclopentaquinolinone Derivatives from Indolyl‐ynones via Silver‐Catalyzed One‐pot Reaction
Authors: Han Guifang , Xue Li , Zhao Lili , Zhu Tiaozhen , Hou Jingli , Song Yuguang , Liu Yangping 
Published: December 2018

AbstractAn unexpected Ag(I)‐catalyzed cascade reaction between substituted indolyl‐ynone and Togni's reagent has been disclosed in which multiple processes occur including indole dearomatization, ring expansion, trifluoro‐methylation and dehydrogenation. This one‐pot reaction can be used to conveniently access diverse CF3‐containing multisubstituted cyclopentaquinolinone scaffolds in moderate to good yields.magnified image
Beef cattle farmers’ marketing preferences for selling local beef
Authors: DeLong Karen L. , Jensen Kimberly L. , Griffith Andrew P. , McLeod Elizabeth 
Published: December 2018

AbstractTo meet the growing consumer demand for local foods, there has been increased interest by farmers to produce local foods. One facet of meeting this demand is how farmers may prefer to market their locally produced products. In this study, we examine beef cattle farmers’ marketing preferences for selling a Tennessee Certified Beef product. Data from a 2016 Tennessee beef cattle farmer survey (n = 428) was used to estimate a multinomial logit model of the probability of farmers preferring a particular marketing arrangement. The most commonly selected marketing arrangement was a farmer cooperatively owned processing facility (43%), followed by a beef marketing cooperative (39%), and private contracting of finished cattle to a third party for slaughter (18%). Factors influencing participation in the specific marketing arrangements included farmer and farm characteristics, risk preferences, and location.
Simultaneous quantification of oxybutynin and its active metabolite N‐desethyl oxybutynin in rat plasma by ultra‐high‐performance liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study of oxybutynin transdermal patch
Authors: Tian Yongzhi , Wen Yongqing , Sun Jinghan , Zhao Longshan , Xiong Zhili , Qin Feng 
Published: December 2018

AbstractA rapid, selective and sensitive ultra‐high‐performance liquid chromatography–tandem mass spectrometry method was developed to simultaneously determine oxybutynin and its active metabolite N‐desethyl oxybutynin in rat plasma. A 0.1 mL sample of plasma was extracted with n‐hexane. Chromatographic separation was performed on a UPLC BEH C18 column (2.1 × 100 mm i.d.,1.7 μm) with mobile phase of methanol–water (containing 2 mmol/L ammonium acetate and 0.1% formic acid; 90:10, v/v). The detection was performed in positive selected reaction monitoring mode. Each plasma sample was chromatographed within 3 min. The linear calibration curves were obtained in the concentration range of 0.0944–189 ng/mL (r ≥ 0.99) for oxybutynin and 0.226–18.0 ng/mL (r ≥ 0.99) for N‐desethyl oxybutynin. The intra‐ and inter‐day precision (relative standard deviation) values were not more than 14% and the accuracy (relative error) was within ±7.6%. The method described was superior to previous methods for the quantitation of oxybutynin with three product ions and was successfully applied to a pharmacokinetic study of oxybutynin and its active metabolite N‐desethyl oxybutynin in rat plasma after transdermal administration.
Palliative care initiation in pediatric oncology patients: A systematic review
Authors: Cheng Brian T. , Rost Michael , De Clercq Eva , Arnold Louisa , Elger Bernice S. , Wangmo Tenzin 
Published: December 2018

AbstractPalliative care (PC) aims to improve quality of life for patients and their families. The World Health Organization and American Academy of Pediatrics recommend that PC starts at diagnosis for children with cancer. This systematic review describes studies that reported PC timing in the pediatric oncology population. The following databases were searched: PubMed, Web of Science, CINAHL, and PsycInfo databases. Studies that reported time of PC initiation were independently screened and reviewed by 2 researchers. Studies describing pilot initiatives, published prior to 1998, not written in English, or providing no empirical time information on PC were excluded. Extracted data included sample characteristics and timing of PC discussion and initiation. Of 1120 identified citations, 16 articles met the inclusion criteria and comprised the study cohort. Overall, 54.5% of pediatric oncology patients received any palliative service prior to death. Data revealed PC discussion does not occur until late in the illness trajectory, and PC does not begin until close to time of death. Despite efforts to spur earlier initiation, many pediatric oncology patients do not receive any palliative care service, and those who do, predominantly receive it near the time of death. Delays occur both at first PC discussion and at PC initiation. Efforts for early PC integration must recognize the complex determinants of PC utilization across the illness timeline.
Insights into the Oxidative Palladium‐Catalyzed Regioselective Synthesis of 3‐Arylindoles from N−Ts‐Anilines and Styrenes: A Computational Study
Authors: Qiao Yan , Zhao Jimin , Chang Junbiao , Wei Donghui 
Published: December 2018

AbstractPalladium (Pd)‐catalyzed intermolecular oxidative annulation represents as an attractive approach to regioselective synthesis of 2/3‐arylindoles, but the unexpected regioselectivity remains to be one of the most challenging questions in this field. Herein, we present a systematically theoretical study on the Pd‐catalyzed regioselective synthesis of 3‐arylindoles from N−Ts‐anilines and styrenes with the presence of oxidant, special ligand, and benzoquinone (BQ) additive. A refined mechanism, in which the single six‐membered ring CMD‐type transition state was involved in the C−H activation of styrenes, is obviously more energetically favorable than the proposed pathway associated with the [6‐6] palladacyclic transition state in the experimental report (Youn et al., Angew. Chem. Int. Ed. 2017, 56, 1–6). The preferred reaction pathway consists of N−H deprotonation, CMD‐type C−H bond activation of styrenes, carbopalladation, BQ‐assisted β‐C−H activation, α‐C−H bond activation, and reductive elimination. With BQ additive, the carbopalladation is the key step for controlling the regioselectivity, and the favorable Pd−O coordinating bond interaction between Pd and BQ as well as the less distortion degree of styrene in the C3‐regioselective transition state determine the observed regioselectivity. The obtained computational insights should be valuable for understanding and rational design of the transition metal‐catalyzed oxidative annulation reactions with special regioselectivity.