bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rewiring of RSK-PDZ interactions by linear motif phosphorylation
Authors: Gogl Gergo , Biri-Kovacs Beata , Durbesson Fabien , Jane Pau , Nomine Yves , Kostmann Camille , Bilics Viktoria , Simon Marton , Remenyi Attila , Vincentelli Renaud , Trave Gilles , Nyitray Laszlo 
Published: September 2018

ABSTRACTProtein phosphorylation is a key regulator of protein-protein interactions. How does the interactome of a protein change during extracellular stimulations? While many individual examples of phosphorylation-regulated interactions were described previously, studies addressing the interactome changes induced by a particular phosphorylation event remain scarce. Here, we try to answer this question, by focusing on interactions between a phosphorylable PDZ-binding linear motif and the entire complement of human PDZ domains. Using a combination ofin vitroquantitative techniques and cell-based approaches, we demonstrate that the activation of the mitotic effector kinase RSK1 causes dramatic changes in its connectivity with PDZ domain containing proteins. These changes consist of modulations of the binding affinity of numerous interactions, rather than on/off switching of a few interactions. Our results highlight the previously unappreciated role of phosphorylation in the complex and subtle rewiring of large numbers of protein-protein interactions.
Do instrumental and symbolic factors interact in influencing employer attractiveness and job pursuit intention?
Authors: Kumari Shweta , Saini Gordhan K. 
Published: September 2018

PurposeThe changing demographics of talent market calls for a better understanding of the expectations of diverse job seekers. However, there is limited research on employer attractiveness (EA) factors which cover the expectations of new generation job seekers. The purpose of this paper is to examine the effect of career growth opportunities (CGO), work–life benefits (WLB) and corporate social responsibility (CSR) reputation on the perceived attractiveness of an organization as an employer and the job pursuit intention (JPI) of job seekers.Design/methodology/approachA 2 (CGO: many vs limited)×2 (WLB: many vs limited)×2 (CSR reputation: high vs low) between-subjects experimental design was used for this study. A total of 240 respondents participated in the study.FindingsThe results showed that provision of CGO had the highest effect on both EA and JPI. This effect was strong enough to compensate for limited WLB and a low CSR reputation. A significant interaction effect between CGO and CSR reputation revealed that the effect of CSR reputation on EA depends on the availability of many or limited CGO.Originality/valueThe study contributes and expands literature on attributes relevant in job choice decisions by providing useful insights regarding how job seekers weigh these attributes while making an employment choice. Also, the study offers suggestions for designing organizations’ recruitment strategy for attracting talent.
Analytical determination of speed-torque and speed-current curves of single-cage induction motor under supply voltage and frequency variations
Authors: Aree Pichai 
Published: September 2018

Purpose
An important characteristic of most induction motors is speed- or slip-torque curve. A simplified Kloss formula is widely used for describing speed-torque characteristic because it is fairly simple. Only two parameters related to break-down torque and break-down slip are regarded as input parameters. Because this simplified formula ignores an unknown parameter that is a ratio between Thevenin’s and rotor resistances, an accurate torque curve characteristic may not be fully obtained over an entire speed range. Moreover, the conventional Kloss formula does not offer a speed-torque curve calculation when motor’s supply voltages and frequencies are deviated from rated values. Hence, the purpose of this paper is to present an extension of Kloss formula, which allows a more precise estimation of speed-torque and speed-current curves of single-cage three-phase induction motors over a wide range of speeds at different motor’s operating voltages, frequencies and rotor-circuit resistances.

Design/methodology/approach
The analytical approach is mainly used for determining all key parameters in the Kloss formula using a known set of data such as rated torque, starting torque, break-down torque and rated speed, in which they can be obtained from motor’s manufacturer.

Findings
The speed-torque and speed-current curves taken from laboratory measurements are compared with those from the calculations. Good agreements between them are fully observed.

Originality/value
This analytical approach is useful in providing an accurate speed-torque and speed-current curves required for most steady-state analysis.
Risk-aware decision support with constrained goal models
Authors: Argyropoulos Nikolaos , Angelopoulos Konstantinos , Mouratidis Haralambos , Fish Andrew 
Published: September 2018

Purpose
The selection of security configurations for complex information systems is a cumbersome process. Decision-making regarding the choice of security countermeasures has to take into consideration a multitude of, often conflicting, functional and non-functional system goals. Therefore, a structured method to support crucial security decisions during a system’s design that can take account of risk whilst providing feedback on the optimal decisions within specific scenarios would be valuable.

Design/methodology/approach
Secure Tropos is a well-established security requirements engineering methodology, but it has no concepts of Risk, whilst Constrained Goal Models are an existing method to support relevant automated reasoning tasks. Hence we bridge these methods, by extending Secure Tropos to incorporate the concept of Risk, so that the elicitation and analysis of security requirements can be complimented by a systematic risk assessment process during a system’s design time and supporting the reasoning regarding the selection of optimal security configurations with respect to multiple system objectives and constraints, via constrained goal models.

Findings
As a means of conceptual evaluation, to give an idea of the applicability of the approach and to check if alterations may be desirable, a case study of its application to an e-government information system is presented. The proposed approach is able to generate security mechanism configurations for multiple optimisation scenarios that are provided, whilst there are limitations in terms of a natural trade-off of information levels of risk assessment that are required to be elicited.

Originality/value
The proposed approach adds additional value via its flexibility in permitting the consideration of different optimisation scenarios by prioritising different system goals and the automated reasoning support.
A model-based approach to support privacy compliance
Authors: Alshammari Majed , Simpson Andrew 
Published: September 2018

Purpose
Concerns over data-processing activities that may lead to privacy violations or harms have motivated the development of legal frameworks and standards. Further, software engineers are increasingly expected to develop and maintain privacy-aware systems that both comply with such frameworks and standards and meet reasonable expectations of privacy. This paper aims to facilitate reasoning about privacy compliance, from legal frameworks and standards, with a view to providing necessary technical assurances.

Design/methodology/approach
The authors show how the standard extension mechanisms of the UML meta-model might be used to specify and represent data-processing activities in a way that is amenable to privacy compliance checking and assurance.

Findings
The authors demonstrate the usefulness and applicability of the extension mechanisms in specifying key aspects of privacy principles as assumptions and requirements, as well as in providing criteria for the evaluation of these aspects to assess whether the model meets these requirements.

Originality/value
First, the authors show how key aspects of abstract privacy principles can be modelled using stereotypes and tagged values as privacy assumptions and requirements. Second, the authors show how compliance with these principles can be assured via constraints that establish rules for the evaluation of these requirements.
A grounded theory approach to security policy elicitation
Authors: Foley Simon N. , Rooney Vivien 
Published: September 2018

Purpose
In this paper, the authors consider how qualitative research techniques that are used in applied psychology to understand a person’s feelings and needs provides a means to elicit their security needs.

Design/methodology/approach
Recognizing that the codes uncovered during a grounded theory analysis of semi-structured interview data can be interpreted as policy attributes, the paper develops a grounded theory-based methodology that can be extended to elicit attribute-based access control style policies. In this methodology, user-participants are interviewed and machine learning is used to build a Bayesian network-based policy from the subsequent (grounded theory) analysis of the interview data.

Findings
Using a running example – based on a social psychology research study centered around photograph sharing – the paper demonstrates that in principle, qualitative research techniques can be used in a systematic manner to elicit security policy requirements.

Originality/value
While in principle qualitative research techniques can be used to elicit user requirements, the originality of this paper is a systematic methodology and its mapping into what is actionable, that is, providing a means to generate a machine-interpretable security policy at the end of the elicitation process.
Female labour force participation and economic development
Authors: Choudhry Misbah Tanveer , Elhorst Paul 
Published: September 2018

Purpose
The purpose of this paper is to present a theoretical model, which is aggregated across individuals to analyse the labour force participation rate, and empirical results to provide evidence of a U-shaped relationship between women’s labour force participation and economic development.

Design/methodology/approach
The U-shaped relationship is investigated by employing a panel data approach of 40 countries around the world over the period 1960–2005. It is investigated whether the labour force behaviour of women in different age groups can be lumped together by considering ten different age groups.

Findings
The paper finds evidence in favour of the U-shaped relationship. For every age group and explanatory variable in the model, a particular point is found where the regime of falling participation rates changes into a regime of rising participation rates.

Research limitations/implications
To evaluate this relationship, microeconomic analysis with primary data can also provide significant insights.

Social implications
Every country can narrow the gap between the labour participation rates of men and women in the long term. Fertility decline, shifts of employment to services, part-time work, increased opportunities in education, and the capital-to-labour ratio as a measure for economic development are the key determinants.

Originality/value
In addition to the U-shaped relationship, considerable research has been carried out on demographic transition. This paper brings these two strands of literature together, by econometrically investigating the impact of demographic transition on female labour force participation given its U-shaped relation with economic development, i.e., turning points for different explanatory variables are calculated and their implications for economic growth are discussed.
Wage effects of labour market entry via temporary work agency employment
Authors: Buch Tanja , Niebuhr Annekatrin 
Published: September 2018

PurposeThe purpose of this paper is to investigate whether labour market entry via temporary work has any (persistent) effects on labour market outcomes.Design/methodology/approachUsing unique data on several cohorts of graduates from the German apprenticeship system, the authors interpret labour market entry via temporary work agency (TWA) work as a treatment and apply propensity score matching and the control function approach to investigate corresponding effects.FindingsThe results indicate a pronounced wage gap but no significant wage disadvantage in the medium term for graduates who switch to regular employment. Nevertheless, approximately 30 per cent of the graduates do not manage to leave the temporary help sector and, as a result, suffer persistent wage penalties.Originality/valueThe numerous studies that investigate the consequences of TWA work on individual labour market performance have not considered the specific situation of young workers after graduation. The rapidly increasing percentage of TWA jobs and the above average share of young workers among temporary workers call for corresponding evidence.
Toward a maturity model for the application of social media in healthcare
Authors: Jami Pour Mona , Jafari Seyed Mohammadbagher 
Published: September 2018

Purpose
The advent of new technologies and change of patients’ behavioral patterns have triggered the provision of medical services through social media. Although the intersection between social media and health has received considerable research attention, there is little research on how health institutions implement social media strategy; thus a roadmap is required to navigate these technological initiatives. So, the purpose of this paper is to overcome this challenge by developing the Health 2.0 maturity model in the healthcare field.

Design/methodology/approach
To obtain this aim, the mixed method was applied in this research. In the first step, qualitative research method was used. In this step, along with comprehensive literature review, semi-structured interviews were conducted with the healthcare professionals to find the practices and capabilities of Health 2.0. In the second step, the proposed key dimensions (KD) were assessed and prioritized based on the views of the healthcare professionals using the quantitative survey method. Finally, by considering the architecture of Health 2.0 maturity model, the KDs were assigned to maturity levels based on their priority of implementation using a focus group.

Findings
The proposed maturity model is composed of six KDs and five maturity levels based on the Capability Maturity Model Integration architecture. The KDs, as well as their implementation order and weights in the proposed maturity model are presented as a roadmap for applying Health 2.0 effectively.

Practical implications
Employing the Health 2.0 maturity model enables health institutions to assess the current social media capabilities and guide them to select appropriate strategies for progress. Due to the descriptive nature of the proposed model, it allows managers to conduct process-based assessments regarding health 2.0 implementation.

Originality/value
Health 2.0 has been a recurring theme on the agenda of healthcare institutions, but no sensitive tool is available to measure its growth processes. This paper explores the much ignored but critically important subject of Health 2.0 maturity model and its implementation roadmap. The main contribution of this paper is to introduce an integrated roadmap containing the most important capabilities of Health 2.0. The proposed model is both descriptive and prescriptive in nature, and has a significant theoretical contribution to healthcare studies. This paper provides a mechanism to benchmark Health 2.0 efforts and to develop a progressive strategy that would improve its activities.
Origin and phylogenetic relationships of [4Fe–4S]‐containing O2 sensors of bacteria
Authors: Barth C. , Weiss M. C. , Roettger M. , Martin W. F. , Unden G. 
Published: September 2018

SummaryThe advent of environmental O2 about 2.5 billion years ago forced microbes to metabolically adapt and to develop mechanisms for O2 sensing. Sensing of O2 by [4Fe–4S]2+ to [2Fe–2S]2+ cluster conversion represents an ancient mechanism that is used by FNREc (Escherichia coli), FNRBs (Bacillus subtilis), NreBSa (Staphylococcus aureus) and WhiB3Mt (Mycobacterium tuberculosis). The phylogenetic relationship of these sensors was investigated. FNREc homologues are restricted to the proteobacteria and a few representatives from other phyla. Homologues of FNRBs and NreBSa are located within the bacilli, of WhiB3 within the actinobacteria. Archaea contain no homologues. The data reveal no similarity between the FNREc, FNRBs, NreBSa and WhiB3 sensor families on the sequence and structural levels. These O2 sensor families arose independently in phyla that were already present at the time O2 appeared, their members were subsequently distributed by lateral gene transfer. The chemistry of [4Fe–4S] and [2Fe–2S] cluster formation and interconversion appears to be shared by the sensor protein families. The type of signal output is, however, family specific. The homologues of FNREc and NreBSa vary with regard to the number of Cys residues that coordinate the cluster. It is suggested that the variants derive from lateral gene transfer and gained other functions.
Acute‐on‐chronic liver failure exists in patients with hepatitis B virus‐related decompensated cirrhosis
Authors: Wang Shi Jin , Yin Shan , Gu Wen Yi , Zhang Yan , Li Hai 
Published: September 2018

OBJECTIVEThis research sought to verify whether acute‐on‐chronic liver failure (ACLF) develops in hepatitis B virus (HBV)‐related cirrhotic patients with previous decompensation and to identify the similarity between assumed ACLF patients and those with ACLF that developed from compensated cirrhosis.METHODSPatients with HBV‐related cirrhosis were retrospectively screened and divided into the cirrhotic patients with first acute decompensation (AD) group and those with previous decompensation. Patients’ characteristics, changes in laboratory results during hospitalization such as serum levels of total bilirubin (TB), creatinine (Cr) and white blood cell (WBC) counts, the Model for End‐Stage Liver Disease (MELD) score and the 28‐day and 1‐year mortality rates were compared.RESULTSAltogether 890 patients were enrolled and divided into the compensated cirrhotic group with first AD (n = 400; 157 of whom diagnosed as ACLF within 28 days after admission according to the European Association for the Study of the Liver‐Chronic Liver Failure [EASL‐CLIF] criteria) and those with previous decompensation (n = 490; of whom 143 met the ACLF criteria [assumed ACLF]). There was no significant difference in 28‐day mortality between the assumed ACLF group with previous decompensation and ACLF group with first AD. The WBC count, TB and Cr levels, international normalized ratio and MELD score exhibited similar variations in both groups at days 1, 7 and 28; however, these values in both ACLF groups significantly differed from the non‐ACLF group.CONCLUSIONHBV‐related cirrhotic patients with previous decompensation who met the ACLF criteria had similar characteristic to ACLF patients with first AD.
Getting Beyond the Narratives: An Open Letter to the Activist Community
Authors: Greer John Michael 
Published: September 2018

AbstractThis is my response to a book, Globalize Liberation, edited by David Solnit and published in 2004. Media activists James John Bell and Patrick Reinsborough sent me a copy and asked for my thoughts about it; the result turned into an essay of some length, which got a certain amount of exposure and discussion online. Looking at the travails of progressive activism since its publication, I find very little that needs revision, except the tone of relative optimism expressed toward the end.
Role of corneal nerves in ocular surface homeostasis and disease
Authors: Labetoulle Marc , Baudouin Christophe , Calonge Margarita , Merayo‐Lloves Jesús , Boboridis Kostas G. , Akova Yonca A. , Aragona Pasquale , Geerling Gerd , Messmer Elisabeth M. , Benítez‐del‐Castillo José 
Published: September 2018

AbstractCorneal nerves are key components of the physiological system that controls ocular surface homeostasis. The cornea is primarily innervated by the ophthalmic branch of the trigeminal nerves (cranial nerve V), which distend bilaterally from the pons. The nasociliary branch (afferent) of the ophthalmic nerve is sensory for cornea, eyelid and conjunctiva. These nerve fibres play a role in sensing temperature, chemical and mechanical stimuli, and pain, whereas, branches of the facial nerve (cranial nerve VII) contain motor nerves that control blinking and autonomic (sympathetic and a paucity of parasympathetic) fibres that stimulate tear production and secretion via feedback loops between the ocular surface, lacrimal glands and brain. Disruption of these nerves with interruption of neural feedback loops between the ocular surface and lacrimal glands can lead to corneal diseases such as dry eye disease (DED) and neurotrophic keratopathy (NK). Inversely, hypersensitivity of the nerve fibres and/or dysregulation of pain‐controlling nervous centres may lead to neuropathic pain. Recently, medications that specifically target regeneration of corneal nerves have started to become available – and considering the high prevalence of diseases associated with corneal nerve dysfunction, these agents promise to fulfil a hitherto important unmet need. In this review, we explore the physiology of corneal nerves, the pathology of corneal nerve diseases and how these relate to neuropathic pain, NK and DED. We also discuss what novel treatments may be useful against diseases involving corneal nerves.
The role of multimodal treatment in Crohn′s disease patients with perianal fistula: a multicentre retrospective cohort study
Authors: Sebastian Shaji , Black Christopher , Pugliese Daniela , Armuzzi Alessandro , Sahnan Kapil , Elkady Soad M. , Katsanos Kostas H. , Christodoulou Demitrios K. , Selinger Christian , Maconi Giovanni , Fearnhead Nicola S. , Kopylov Uri , Davidov Yana , Bosca‐Watts Marta M. , Ellul Pierre , Muscat Martina , Karmiris Konstantinos , Hart Ailsa L. , Danese Silvio , Ben‐Horin Shomron , Fiorino Gionata 
Published: September 2018

SummaryBackgroundTreatment paradigms for Crohn′s disease with perianal fistulae (CD‐pAF) are evolving.AimsTo study the impact of multimodality treatment in CD‐pAF on recurrence rates and the need for re‐interventions and to identify predictive factors for these outcomes.MethodsThis was a multinational multicentre retrospective cohort study. Multimodality approach was defined as using a combination of medical treatments (anti‐TNFs ± immunomodulators ± antibiotics) along with surgical approach (examination under anaesthesia (EUA) ± seton drainage) at diagnosis of CD‐pAF. Univariable and multivariable analyses were performed for variables indicative of the need for reintervention.ResultsA total of 253 patients were included. 65% of patients received multimodality approach. Multimodality treatment resulted in complete fistula healing in 52% of patients. Re‐intervention was needed in 27% of patients with simple and in 40.3% of those with complex fistula. On multivariable analysis multimodality treatment (OR: 0.35, 95% CI: 0.17‐0.57, P = 0.001), seton removal (OR: 0.090, 95% CI: 0.027‐0.30, P = 0.0001, therapy with infliximab (OR: 0.19, 95% CI: 0.06‐0.64, P = 0.007), and therapy with adalimumab (OR: 0.12, "95% CI: 0.026‐0.56, P = 0.007) were predictive of avoiding repeat surgery. Proctitis (OR: 3.76, 95% CI: 1.09‐12.96, P = 0.03) was predictive of the need for radical surgery (proctectomy, diverting stoma) while multimodality treatment reduced the need for radical surgery (OR: 0.21, 95% CI: 0.05‐0.81, P = 0.02).ConclusionsMultimodality treatment, anti‐TNFs use, and removal of setons after multimodality treatment can result in improved outcomes in CD patients with perianal fistulae and reduce the need for repeat surgery and radical surgery.