bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revitalized and synovialized allograft for intrasynovial flexor tendon reconstruction in an in vivo canine model
Authors: Zhang Tao , Lu Cheng‐Chang , Reisdorf Ramona L. , Thoreson Andrew R. , Gingery Anne , Moran Steven L. , Amadio Peter C. , Zhao Chunfeng 
Published: August 2018

ABSTRACTThis study was to test our hypothesis that flexor tendon reconstruction with an allograft revitalized with bone marrow stromal cells (BMSCs) and synovialized with carbodiimide derivatized autologous synovial fluid (cd‐SYN) would result in better digit functional restoration than the conventional allograft tendon. A total of 32 flexor digital profundus tendons from the second and fifth digit of 16 dogs were created a repair failure model first. Then, failed‐repaired tendons were reconstructed with either a revitalized‐synovialized allograft tendon or a clinical standard autograft tendon (control group). The allograft tendon was seeded with autologous BMSCs in multiple slits and the graft surface was coated with cd‐SYN. A 6 weeks after tendon reconstruction, the digits were harvested and evaluated for digit function, adhesion status, tendon gliding resistance, attachment strength, cell viability, and histologic factors. The allograft group had significantly improved digit function compared with the control group through decreased work of flexion, increased digit range of motion under 2‐Newton force, and less adhesion score (p < .05). However, the distal attachment‐site strength and stiffness in the allograft tendon were significantly weaker than the autografts (p < .05). No significant difference was found for gliding resistance. Histologically, allograft tendons coated with allograft had smoother surfaces and showed tendon‐to‐bone and tendon‐to‐tendon incorporation. Viable BMSCs were found in the tendon slits 6 weeks after the graft. In conclusion, cellular lubricant‐based modification of allograft tendons improved digit function and reduced the adhesions compared with autograft for flexor tendon reconstruction. However, improvement of graft‐to‐host tendon healing is still challenging. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2218–2227, 2018.
Interaction with macrophages attenuates equine fibroblast‐like synoviocyte ADAMTS5 (aggrecanase‐2) gene expression following inflammatory stimulation
Authors: Morgan Rhiannon E. , Clegg Peter D. , Hunt John A. , Innes John F. , Tew Simon R. 
Published: August 2018

ABSTRACTThe joint synovium consists of a heterogeneous cell population, chiefly comprised of macrophages, and fibroblast‐like synoviocytes (FLS). An inter‐species co‐culture model was developed to examine interactions between these cells. Equine FLS and the canine macrophage line DH82 were differentially labeled using fluorescent markers and results from direct co‐culture compared with those from both indirect co‐culture, and conditioned media experiments. The transcript expression of IL‐1β, IL‐6, ADAMTS4, and ADAMTS5 in each cell type were determined using species‐specific qPCR assays. Lipopolysaccharide stimulation of EFLS rapidly increased IL‐1β, IL‐6, ADAMTS4, and ADAMTS5 mRNAs. The induction of ADAMTS5 was significantly reduced when equine FLS were cultured with DH82 cells directly or indirectly. Exposure of equine FLS to denatured conditioned media also significantly reduced ADAMTS5 induction. DH82 cells increased interleukin‐1β expression substantially following LPS stimulation. However, knockdown of interleukin‐1β in DH82 cells, or inhibition of NF‐κB in equine FLS prior to co‐culture did not change the inhibitory effect on equine FLS ADAMTS5 gene expression. This work indicates that macrophages can influence FLS gene expression through a soluble mediator, and modulate the expression of an enzyme critical in osteoarthritis pathology during inflammatory stimulation. © 2018 The Authors. Journal of Orthopaedic Research® Published by WileyPeriodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res 36:2178–2185, 2018.
Use of Ultrasonography for Lung Transplant Recipients on Postoperative Care
Authors: Droneau Sylvain , Noel‐Savina Elise , Plat Gavin , Murris‐Espin Marlene , Leborgne‐Krams Aurélie , Brouchet Laurent , Dahan Marcel , Didier Alain 
Published: August 2018

The authors report their findings regarding lung ultrasound profiles in a population of transplant recipients. Twenty‐two patients were studied once each in multiple different ultrasound windows focusing on pleural, lung, and diaphragmatic signatures. All studies were performed in presumably otherwise healthy recipients at an outpatient follow‐up visit at least 3 months after transplantation. Those with recent pulmonary infections or decline in lung function were excluded from enrollment. The majority of scans revealed otherwise normal lungs with lung sliding, but there were more abnormalities than one would expect in a healthy control group.Lung ultrasonography will likely never replace other cross‐sectional imaging given its inherent visual limitations but adds another modality to interrogate the lung/pleural interface and diaphragmatic function.
Description of relations between regularity coefficients of time‐varying linear systems
Authors: Czornik Adam , Niezabitowski Michał , Vaidzelevich Aliaksei 
Published: August 2018

AbstractIn this paper we consider regularity coefficients of a discrete linear time‐varying systems. The main result presents a complete description of the relations between Lyapunov, Perron and Grobman regularity coefficients of mutually adjoint systems.
Predictive Models for Kinetic Parameters of Cycloaddition Reactions
Authors: Glavatskikh Marta , Madzhidov Timur , Horvath Dragos , Nugmanov Ramil , Gimadiev Timur , Malakhova Daria , Marcou Gilles , Varnek Alexandre 
Published: August 2018

AbstractThis paper reports SVR (Support Vector Regression) and GTM (Generative Topographic Mapping) modeling of three kinetic properties of cycloaddition reactions: rate constant (logk), activation energy (Ea) and pre‐exponential factor (logA). A data set of 1849 reactions, comprising (4+2), (3+2) and (2+2) cycloadditions (CA) were studied in different solvents and at different temperatures. The reactions were encoded by the ISIDA fragment descriptors generated for Condensed Graph of Reaction (CGR). For a given reaction, a CGR condenses structures of all the reactants and products into one single molecular graph, described both by conventional chemical bonds and “dynamical” bonds characterizing chemical transformations. Different scenarios of logk assessment were exploited: direct modeling, application of the Arrhenius equation and temperature‐scaled GTM landscapes. The logk models with optimal cross‐validated statistics (Q2=0.78–0.94 RMSE=0.45–0.86) have been challenged to predict rates for the external test set of 200 reactions, comprising both reactions that were not present in the training set, and training set transformations performed under different reaction conditions. The models are freely available on our web‐server: http://cimm.kpfu.ru/models.
Margin and PTV volume reduction using a population based library of plans strategy for rectal cancer radiotherapy
Authors: Beekman Chris , van Triest Baukelien , van Beek Suzanne , Sonke Jan‐Jakob , Remeijer Peter 
Published: August 2018

PurposeDay‐to‐day shape variation in the rectum CTV results in considerable geometric uncertainties during rectal cancer radiotherapy. To ensure coverage a large CTV‐to‐PTV margin is required. The purpose of this study was to increase the accuracy of treatment delivery by building a population based library of planning CTVs for rectal cancer patients and to evaluate its potential for rectum PTV margin and PTV volume reduction.MethodsAnalysis was done retrospectively on 33 early‐stage rectal cancer patients with daily repeat CTs who received short‐course pre‐operative radiotherapy in 5 fractions of 5 Gy. We created signed distance maps from the planning rectum CTV to each of the repeat CTVs, from which we calculated the group mean, systematic and random error. The correlation between different regions of the rectum CTV was analyzed and used in combination with the distance maps to create the library of nine planning CTVs. For each of the repeat CTVs the best fitting CTV structure in the library was automatically selected defined by the plan that minimized the mean absolute distance between the repeat and library CTV. Residual distance maps were calculated from which a new PTV margin was constructed. Bootstrapping was performed on the margin difference to assess its significance.ResultsResidual errors were found to decrease with the number of plans in the library, but adding more than five plans yields negligible further error reduction. Margin reduction of up to 50% was achieved at the upper‐anterior site of the mesorectum. The average PTV volume decreased by 15.5% when a library is introduced.ConclusionsA library of plans strategy for rectal cancer based on population statistics is feasible and results in a considerably reduced average rectum PTV volume compared to conventional radiotherapy.
A bottom‐up design for spatial search in large networks and clouds
Authors: Uddin Misbah , Stadler Rolf , Clemm Alexander 
Published: August 2018

SummaryInformation in networked systems often has spatial semantics: routers, sensors, or virtual machines have coordinates in a geographical or virtual space, for instance. In this paper, we propose a design for a spatial search system that processes queries against spatial information that is maintained in local databases inside a large networked system. In contrast to previous works in spatial databases and peer‐to‐peer designs, our design is bottom‐up, which makes query routing network aware and thus efficient, and which facilitates system bootstrapping and adaptation. Key to our design is a protocol that creates and maintains a distributed index of object locations based on information from local databases and the underlying network topology. The index builds upon minimum bounding rectangles to efficiently encode locations. We present a generic search protocol that is based on an echo protocol and uses the index to prune the search space and perform query routing. The response times of search queries increase with the diameter of the network, which is asymptotically optimal. We study the performance of the protocol through simulation in static and dynamic network environments, for different network topologies, and for network sizes up to 100 000 nodes. In most experiments, the overhead incurred by our protocol lies well below 30% of a hypothetical optimal protocol. In addition, the protocol provides high accuracy under significant churn.
Iterative coupling algorithms for large multidomain problems with the boundary element method
Authors: Wang Bin , Feng Yin , Pieraccini Sandra , Scialò Stefano , Fidelibus Corrado 
Published: August 2018

SummaryA new parallel Robin‐Robin adaptive iterative coupling algorithm with dynamic relaxation parameters is proposed for the boundary element method (BEM), and relaxation parameters are derived for other existing iterative coupling algorithms. The performances of the new algorithm and of the modified existing algorithms are investigated in terms of convergence properties with respect to the number of subdomains, mesh density, interface mesh conformity, and BEM element types. Results show that the number of subdomains and the refinement level of the mesh are the two dominant factors affecting the performances of the considered algorithms. The proposed parallel Robin‐Robin algorithm shows the best overall convergence behavior for the tested large problems, thanks to its effectiveness in handling complex boundary conditions and large number of subdomains, thus resulting to be very promising for efficient parallel BEM computing and large coupling problems.Source code is available at https://github.com/BinWang0213/PyBEM2D.
The hybrid element‐free Galerkin method for three‐dimensional wave propagation problems
Authors: Meng Z. J. , Cheng H. , Ma L. D. , Cheng Y. M. 
Published: August 2018

SummaryThis paper presents a hybrid element‐free Galerkin (HEFG) method for solving wave propagation problems. By introducing the dimension split method, the three‐dimensional wave propagation problems are transformed into a series of two‐dimensional ones in other one‐dimensional directions. The two‐dimensional problems are solved using the improved element‐free Galerkin (IEFG) method, and the finite difference method is used in the one‐dimensional splitting direction and the time space. Then, the formulas of the HEFG method for three‐dimensional wave propagation problems are obtained. Numerical examples are selected to show the effectiveness and the advantage of the HEFG method. The convergence and error analysis of the HEFG method are discussed according to the numerical results under different splitting directions, weight functions, node distributions, scale parameters of the influence domain, penalty factors, and time steps. The numerical results are given to show the convergence and advantages of the HEFG method over the IEFG method. Comparing with the IEFG method, the HEFG method has greater computational precision and speed for three‐dimensional wave propagation problems.
The effect of the introduction of the three‐vessel view on the detection rate of transposition of the great arteries and tetralogy of Fallot
Authors: Everwijn Sheila M.P. , van Nisselrooij Amber E.L. , Rozendaal Lieke , Clur Sally‐Ann B. , Pajkrt Eva , Hruda Jaroslav , Linskens Ingeborg H. , van Lith Jan M. , Blom Nico A. , Haak Monique C. 
Published: August 2018

AbstractObjectivesThe aim of this study was to analyze the annual detection rate (DR) of transposition of the great arteries (TGA) and tetrology of Fallot (ToF), after the introduction of the three‐vessel view as a mandatory plane in 2012.MethodsAll registered TGA and ToF cases were retrospectively extracted from our registry between 2007 and 2016. We compared the DR in a 10‐year period, before 2011, with the DR of TGA and ToF after 2012.ResultsIn the period before 2012, 23 of the 52 TGA cases were prenatally detected (44.2%), compared with 42 of the 51 cases (82.4%) after 2012. For ToF, the DRs increased from 28 of 64 cases (43.8%) to 42 of 62 cases (67.7%) in the aforementioned periods. The increase in DRs for both defects was statistically significant (P ≤ 0.001 and P ≤ 0.05).ConclusionsIn this nationally organized prenatal screening program with a quality monitoring system and a uniform protocol, DRs of 82.4% for TGA and 67.7% for ToF were reached after the introduction of the three‐vessel view as a mandatory item. The three‐vessel view significantly contributes to the detection of these conotruncal anomalies.
The treatment of type 2 diabetes in heart failure
Authors: Llano Andrea , McKay Gerry 
Published: August 2018

AbstractHeart failure is a common complication associated with type 2 diabetes (T2DM) and the presence of both carries a poorer prognosis. Recent cardiovascular outcome trials have drawn attention to the contrasting effects of the different classes of agents used in the management of T2DM on heart failure outcomes. While SGLT‐2 inhibitors and some GLP‐1 agonists are associated with improved outcomes with regard to heart failure, thiazolidinediones and certain DPP‐4 inhibitors have been shown to increase this risk.In this review article, we will review each of these drug classes and discuss the evidence, if any, for their use in heart failure. Copyright © 2018 John Wiley & Sons.
Organ‐specific phytohormone synthesis in two Geranium species with antithetical responses to far‐red light enrichment
Authors: Gommers Charlotte M. M. , Buti Sara , Tarkowská Danuše , Pěnčík Aleš , Banda Jason P. , Arricastres Vincent , Pierik Ronald 
Published: August 2018

AbstractPlants growing in high densities experience a reduced red (R) to far‐red (FR) light ratio and shade‐intolerant species respond with accelerated elongation growth to reach the top of the canopy: the shade avoidance syndrome (SAS). FR‐enriched light inactivates phytochrome photoreceptors, which results in subsequent action of several plant hormones regulating growth. SAS is adaptive for shade‐intolerant plants, but is suppressed in shade‐tolerant plant species. Inspired by a previously published transcriptome analysis, we use two species of the genus Geranium here to study the involvement of auxin, brassinosteroids (BRs), and gibberellins (GAs) in supplemental FR‐induced elongation growth. G. pyrenaicum, a shade‐avoiding species, strongly induces auxin and gibberellin levels, but not BR, in elongating petioles. We show that, in this species, FR light perception, hormone synthesis, and growth are local and restricted to the petiole, and not the leaf lamina. Using chemical hormone inhibitors, we confirm the essential role of auxin and GAs in supplemental FR‐induced elongation growth. Shade‐tolerant G. robertianum does not display the change in hormone levels upon FR light enrichment, resulting in the lack of a shade avoidance response.
Understanding the Interaction of Glutamate Salts with Serum Albumin Protected Prism‐Shaped Silver Nanoparticles toward Glutamate Sensing
Authors: Zeng Yuan , Chang Yu‐Hsin , Gharib Mustafa , Parak Wolfgang J. , Chakraborty Indranath 
Published: August 2018

AbstractSurface plasmon spectroscopy of serum albumin protected prism‐shaped silver nanoparticles is used as simple and effective sensing tool to detect glutamate salts. The approach does not require any electrochemical setup to detect glutamates, in contrast to common techniques to detect glutamates in general. Experiments reveal that upon presence of high concentrations of glutamate salts, the prism‐shaped nanoparticles are transformed to smaller‐sized nanoclusters, while the remaining nanoparticles are assembled to form aggregates. Control experiments confirm that the interaction is specific to the serum albumin coating, the prism shape of the nanoparticles, and to silver.
Genetic Modification of Mesenchymal Stem Cells Overexpressing Angiotensin II Type 2 Receptor Increases Cell Migration to Injured Lung in LPS-Induced Acute Lung Injury Mice
Authors: Xu Xiu-Ping , Huang Li-Li , Hu Shu-Ling , Han Ji-Bin , He Hong-Li , Xu Jing-Yuan , Xie Jian-Feng , Liu Ai-Ran , Liu Song-Qiao , Liu Ling , Huang Ying-Zi , Guo Feng-Mei , Yang Yi , Qiu Hai-Bo 
Published: August 2018

Abstract
Although mesenchymal stem cells (MSCs) transplantation has been shown to promote the lung respiration in acute lung injury (ALI) in vivo, its overall restorative capacity appears to be restricted mainly because of low retention in the injured lung. Angiotensin II (Ang II) are upregulated in the injured lung. Our previous study showed that Ang II increased MSCs migration via Ang II type 2 receptor (AT2R). To determine the effect of AT2R in MSCs on their cell migration after systemic injection in ALI mice, a human AT2R expressing lentiviral vector and a lentivirus vector carrying AT2R shRNA were constructed and introduced into human bone marrow MSCs. A mouse model of lipopolysaccharide-induced ALI was used to investigate the migration of AT2R-regulated MSCs and the therapeutic potential in vivo. Overexpression of AT2R dramatically increased Ang II-enhanced human bone marrow MSC migration in vitro. Moreover, MSC-AT2R accumulated in the damaged lung tissue at significantly higher levels than control MSCs 24 and 72 hours after systematic MSC transplantation in ALI mice. Furthermore, MSC-AT2R-injected ALI mice exhibited a significant reduction of pulmonary vascular permeability and improved the lung histopathology and had additional anti-inflammatory effects. In contrast, there were less lung retention in MSC-ShAT2R-injected ALI mice compared with MSC-Shcontrol after transplantation. Thus, MSC-ShAT2R-injected group exhibited a significant increase of pulmonary vascular permeability and resulted in a deteriorative lung inflammation. Our results demonstrate that overexpression of AT2R enhance the migration of MSCs in ALI mice and may provide a new therapeutic strategy for ALI.
Control of Particle Adsorption for Stability of Pickering Emulsions in Microfluidics
Authors: Yao Xiaoxue , Liu Zhou , Ma Mingze , Chao Youchuang , Gao Yongxiang , Kong Tiantian 
Published: August 2018

AbstractStudying the stability of Pickering emulsion is of great interest for applications including catalysis, oil recovery, and cosmetics. Conventional methods emphasize the overall behavior of bulk emulsions and neglect the influence of particle adsorbing dynamics, leading to discrepancies in predicting the shelf‐life of Pickering emulsion–based products. By employing a microfluidic method, the particle adsorption is controlled and the stability of the Pickering emulsions is consequently examined. This approach enables us to elucidate the relationship between the particle adsorption dynamics and the stability of Pickering emulsions on droplet‐level quantitatively. Using oil/water emulsions stabilized by polystyrene nanoparticles as an example, the diffusion‐limited particle adsorption is demonstrated and investigated the stability criteria with respect to particle size, particle concentration, surface chemistry, and ionic strength. This approach offers important insights for application involving Pickering emulsions and provides guidelines to formulate and quantify the Pickering emulsion–based products.
GSEPIM: A roadmap for software process assessment and improvement in the domain of global software development
Authors: Khan Arif Ali , Keung Jacky , Niazi Mahmood , Hussain Shahid , Shameem Mohammad 
Published: August 2018

AbstractSoftware development firms have begun adopting the practice of global software development (GSD). The main reason for the shift toward globalization is the various benefits received by software development firms. However, there are several issues faced by GSD organizations, particularly those associated with software process improvement (SPI). It has been noticed that a formal process improvement approach could assist in successfully executing development activities in GSD. The core objective of this research work is to develop a global software engineering process improvement model (GSEPIM) to assess and improve software process activities in a GSD environment. The proposed model will be developed based on existing models in other domains, an empirical study conducted with GSD practitioners, and an understanding of critical success factors and challenges of SPI. In this study, the first step in the development of GSEPIM is completed by identifying the challenges of SPI in GSD and presenting a solution in the form of a robust framework.