bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Efficient In Vivo Cancer Therapy by an Implantable Magnet Triboelectric Nanogenerator
Authors: Zhao Chaochao , Feng Hongqing , Zhang Lijun , Li Zhe , Zou Yang , Tan Puchuan , Ouyang Han , Jiang Dongjie , Yu Min , Wang Chan , Li Hu , Xu Lingling , Wei Wei , Li Zhou 
Published: January 2019

AbstractIn this work, a nanogenerator‐controlled drug delivery system (DDS) for use in cancer therapy is successfully established. A new magnet triboelectric nanogenerator (MTENG) is fabricated that can guarantee the contact and detach cycle between the two friction layers and effectively increase the TENG output, up to 70 V after implantation. Using a special structural design, without the commonly used spacer, this contacting‐mode MTENG can ensure a high and consistent electricity output after encapsulation and implantation. Doxorubicin‐(DOX‐) loaded red blood cells (RBCs) are employed as the anti‐tumor DDS in this study. After DOX loading, the RBC membranes are stable and the self‐release is very slow. However, upon electric stimulation from the MTENG, the release of DOX is remarkably increased, and falls back to normal again after the stimulation. Thus a controllable DDS is established. The MTENG‐controllable DDS achieves an outstanding killing of carcinomatous cells both in vitro and in vivo at a low DOX dosage. These results demonstrate a prominent therapeutic effect of the MTENG‐controlled DDS for cancer therapy, which is highly promising for application in the clinic.
Chalcogenide Phase Change Material for Active Terahertz Photonics
Authors: Pitchappa Prakash , Kumar Abhishek , Prakash Saurav , Jani Hariom , Venkatesan Thirumalai , Singh Ranjan 
Published: January 2019

AbstractThe strikingly contrasting optical properties of various phases of chalcogenide phase change materials (PCM) has recently led to the development of novel photonic devices such as all‐optical non‐von Neumann memory, nanopixel displays, color rendering, and reconfigurable nanoplasmonics. However, the exploration of chalcogenide photonics is currently limited to optical and infrared frequencies. Here, a phase change material integrated terahertz metamaterial for multilevel nonvolatile resonance switching with spatial and temporal selectivity is demonstrated. By controlling the crystalline proportion of the PCM film, multilevel, non‐volatile, terahertz resonance switching states with long retention time at zero hold power are realized. Spatially selective reconfiguration at sub‐metamaterial scale is shown by delivering electrical stimulus locally through designer interconnect architecture. The PCM metamaterial also features ultrafast optical modulation of terahertz resonances with tunable switching speed based on the crystalline order of the PCM film. The multilevel nonvolatile, spatially selective, and temporally tunable PCM metamaterial will provide a pathway toward development of novel and disruptive terahertz technologies including spatio‐temporal terahertz modulators for high speed wireless communication, neuromorphic photonics, and machine‐learning metamaterials.
Generation of Solvent‐Free 3D Lipid Structure Arrays on High Aspect Ratio Si Microwell Substrate
Authors: Han Won Bae , Kwak Rhokyun , Kang Ji Yoon , Kim Tae Song 
Published: January 2019

AbstractArtificial lipid membranes are versatile platforms that are used extensively in biological assays and sensing applications. Particularly, a 2D bilayer lipid membrane (BLM) has been focused on over the last several decades as it can be formed easily on solid supports by various methods. However, 3D lipid structures with structural advantages, such as large surface area that can accommodate a number of proteins and steric conformation that can react with target molecules efficiently, for use as highly sensitive sensors rarely have been studied due to the technical limitations of sealing and stability. Herein, the growth mechanism and condition for the formation of a solvent‐free, 3D lipid structure array (≈300 000 ea cm−2) tightly bound on a microwell array by a gentle hydration method are investigated. Then, applying an electric field during rehydration step, 3D unilamellar structure array with high uniformity (coefficient of variation (CV): ≈4.9%) can be formed. A pore‐forming protein assay (α‐hemolysin) shows that the proposed structures are completely sealed and have biofunctionality that allows them to be used for fluorescent signal measurement, which is essential for biosensing applications. This approach is expected to be a promising first step toward the development of artificial biomimetic sensory organs that have high sensitivity.
Multifunctional Soft Actuators Based on Anisotropic Paper/Polymer Bilayer Toward Bioinspired Applications
Authors: Hu Ying , Xu Aifeng , Liu Jiaqin , Yang Lulu , Chang Longfei , Huang Majing , Gu Weibing , Wu Guan , Lu Pin , Chen Wei , Wu Yucheng 
Published: January 2019

AbstractDesigning artificial muscle actuators with diversely complex deformation and multifunction is crucial to the soft robots and their bioinspired applications. Herein, by combing the hygroexpansion and thermal expansion commonly existed in nature, electrically driven paper‐based bilayer actuator is fabricated by a simple printing method. This actuator exhibits large (270°) and anisotropic deformation coupled with features of low‐cost, superior stability, and additional reversible color‐change function. More importantly, the tailoring and heat setting are used to further design the actuator shape, thus obtain multiform deformation (bending, elongation, and folding), and more complicated deformation similar to the arm motion. Based on these actuators, variously bioinspired motions can be constructed. Inspired by the structure of the crystalline lens and ciliary muscle in human eyeball, a biomimetic lens which can change the focal length under electrical stimulation is fabricated. Moreover, W‐shaped robotic arm for manipulating microliquid in 3D direction and catapulting the object into air, in‐pipe spiral robotic arm for pushing objects out of the pipe, and artificial snake capable of deformation and color‐change simultaneously, are also fabricated. This paper‐based actuator together with bioinspired design may open new perspective on the multifunctional smart robots and biomimetic devices.
Reversible Specific Vapoluminescence Behavior in Pure Organic Crystals through Hydrogen‐Bonding Docking Strategy
Authors: Xia Guomin , Jiang Zhengjun , Shen Shen , Liang Kangli , Shao Qingqing , Cong Zhenxing , Wang Hongming 
Published: January 2019

AbstractThe design of vapoluminescence materials with high contrast, selectivity, and reversibility toward certain vapors is extremely attractive but remains a long‐standing challenge. In this work, crystallization of squaraine dye (SQ) molecules in different solvents affords two organic crystals (R‐SQ and SQ‐2TFA) with the fluorescence quantum yield up to 0.81, which shows reversible phase transition of the crystals with different emission color via annealing treatment and solvent‐vapor adsorption. From spectral and powder X‐ray diffraction analysis, exposure of green‐emitting R‐SQ crystals to trifluoroacetic acid (TFA) vapor gives cyan‐emitting SQ‐2TFA crystals, while desorption of SQ‐2TFA crystals by heating recovers R‐SQ crystals. With a comparison of their crystal structures, this reversible luminescence alternation is ascribed to the crystal rearrangements with formation and collapse of hydrogen‐bonded organic frameworks between SQ and TFA molecules, thus leads to a docking strategy for specific detection of TFA vapor. Meanwhile, various emission behaviors such as aggregation‐induced emission, crystallization‐induced emission enhancement, and mechanochromism of the crystals are verified. The research not only inaugurates a novel strategy for detection of specific certain vapor in pure organic crystals but also demonstrates a pair of excellent crystalline‐to‐crystalline model for deeply understanding various organic emission behaviors.
Enantioselective Access to Chiral Cyclic Sulfamidates Through Iridium‐Catalyzed Asymmetric Hydrogenation
Authors: Liu Yuanhua , Huang Yi , Yi Zhiyuan , Liu Gongyi , Dong Xiu‐Qin , Zhang Xumu 
Published: January 2019

AbstractThe Iridium‐catalyzed asymmetric hydrogenation of cyclic sulfamidate imines was successfully developed with N‐methylated ZhaoPhos L2 as the ligand. A variety of chiral cyclic sulfamidates were obtained with excellent results (up to 99% yield, 99% ee). Furthermore, this asymmetric hydrogenation can be employed as the key reaction step to prepare the important intermediates in organic synthesis.magnified image
A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions
Authors: Strakosas Xenofon , Selberg John , Zhang Xiaolin , Christie Noah , Hsu Peng‐Hao , Almutairi Adah , Rolandi Marco 
Published: January 2019

AbstractBioelectronic devices that modulate pH can affect critical biological processes including enzymatic activity, oxidative phosphorylation, and neuronal excitability. A major challenge in controlling pH is the high buffering capacity of many biological media. To overcome this challenge, devices need to be able to store and deliver a large number of protons on demand. Here, a bioelectronic modulator that controls pH using palladium nanoparticles contacts with high surface area as a proton storage medium is developed. Reversible electronically triggered acidosis (low pH) and alkalosis (high pH) in physiologically relevant buffer conditions are achieved. As a proof of principle, this new platform is used to control the degradation and fluorescence of acid sensitive polymeric microparticles loaded with a pH sensitive fluorescent dye.
Fine Optimization of Morphology Evolution Kinetics with Binary Additives for Efficient Non‐Fullerene Organic Solar Cells
Authors: Chen Jianya , Bi Zhaozhao , Xu Xianbin , Zhang Qianqian , Yang Shengchun , Guo Shengwei , Yan Hongping , You Wei , Ma Wei 
Published: January 2019

AbstractThe power conversion efficiency of polymer solar cells (PSCs) is strongly affected by active layer morphology. Here, two solvent additives (ODT: octance‐1,8‐dithiol; DIO: 1,8‐diiodooctane) are used to optimize the bulk heterojunction morphology of FTAZ:ITIC‐Th based PSCs and ≈11% efficiency is obtained, which is 10% higher than the untreated device. Based on the morphological characterizations, the influence of binary solvent additives on manipulating molecular packing and phase separation of blend films is successfully revealed. More importantly, in situ grazing incidence wide‐angle X‐ray scattering characterization is adopted to explore the crucial role played by these two solvent additives at different stages of the film‐forming process, that is, ODT influences the initial stage of the film‐forming process, while DIO later establishes the ultimate photoactive film formation. Due to the impacts of two additives at different film processing stages, an optimal ratio of ODT:DIO (0.375%:0.125%) is obtained, which helps in realizing the optimized morphology.
Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
Authors: Krüger Franziska , Kumar Vipin , Monge Pere , Conzelmann Carina , Smith Nikaïa , Gothelf Kurt V. , Tolstrup Martin , Münch Jan , Zelikin Alexander N. 
Published: January 2019

AbstractMacromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.
Bottle size matters: Heterogeneity in the German carbonated soft drink market
Authors: Hoffmann Julia , Bronnmann Julia 
Published: January 2019

AbstractGermany is Europe's largest market for carbonated soft drinks. In 2015, the average per capita consumption of carbonated soft drinks reached 119 L. Furthermore, the market is highly differentiated. This study uses a unique household panel data set of carbonated soft drink consumption in Germany to determine the effect of product and household characteristics on purchase decisions. Characteristics of special interests were product brands, bottle sizes, and households’ brand loyalty. A random parameter logit model is estimated to account explicitly for consumer heterogeneity. The results clearly show that The Coca‐Cola Company is still the market leader on the German market, but private label brands from Aldi and Lidl also have a strong influence. The results further indicate that 63% of households are brand loyal regarding their preferred soft drink brand and prefer small bottle sizes (≤1,500 ml) over large bottle sizes (>1,500 ml).
Significant decline of endangered Antipodes Island penguins: Is extreme weather an additional impact?
Authors: Chilvers B. Louise , Hiscock Johanna A. 
Published: January 2019

Abstract

Worldwide, most crested penguin species (Eudyptes spp.) are in decline. New Zealand's subantarctic Antipodes Islands are of international significance for erect‐crested (Eudyptes sclateri) and rockhopper (Eudyptes filholi) penguins.
Between 1995 and 2011, a 23% decline was recorded in the two penguin species on the Antipodes Islands. In October 2014, nest abundance counts on Antipodes Island were undertaken to determine if this decline was continuing, particularly in light of a significant storm event that hit the Antipodes area in January 2014 causing massive landslides during the penguin breeding season.
All penguin colonies ground counted in 2011 were preferentially ground counted in 2014 or, if time or weather did not allow, were checked with binoculars to confirm colony presence or absence.
Seventy‐three per cent of the colonies and the equivalent of 82% of all nests counted in 2011 were recounted in 2014. Overall, there was a 19% decline in erect‐crested penguin nests between 2011 and 2014. Rockhopper penguins showed a slight increase (2.6%).
Landslides affected 11% of the main islands’ land area and 44% of surveyed nesting colonies. Erect‐crested penguin colonies with approximately 75% or greater of their area impacted by landslides showed a significantly greater decline than unaffected or only partially impacted colonies. Landslides showed a minimal effect on rockhopper nest numbers.
There continues to be a significant decline of erect‐crested penguins at the Antipodes Islands. An increasing occurrence of extreme weather events are predicted with climate change and have the potential to increase land‐based flooding and landslides, adding additional impacts to terrestrial breeding marine species. Greater understanding of what is causing erect‐crested penguin decline is needed to prevent this endangered species from extinction.
Phenyl and Diaryl Ureas with Thiazolo[5,4‐d]pyrimidine Scaffold as Angiogenesis Inhibitors: Design, Synthesis and Biological Evaluation
Authors: Xue Wen‐Jun , Deng Ya‐Hui , Yan Zhong‐Hui , Liu Ji‐Ping , Liu Yu , Sun Li‐Ping 
Published: January 2019

AbstractAngiogenesis is crucial for tumor growth and inhibition of angiogenesis has been regarded as a promising approach for cancer therapy. Vascular endothelial growth factor receptor‐2 (VEGFR‐2) is an important factor in angiogenesis. In this work, a novel series of thiazolo[5,4‐d]pyrimidine derivatives inhibiting angiogenesis were rationally designed and synthesized. Their inhibitory activities against human umbilical vein endothelial cells (HUVEC) were investigated in vitro. 1‐(4‐Fluorophenyl)‐3‐{4‐[(5‐methyl‐2‐phenyl[1,3]thiazolo[5,4‐d]pyrimidin‐7‐yl)amino]phenyl}urea (19b) and 1‐(3‐Fluorophenyl)‐3‐{4‐[(5‐methyl‐2‐phenyl[1,3]thiazolo[5,4‐d]pyrimidin‐7‐yl)amino]phenyl}urea (19g) exhibited the most potent inhibitory effect on HUVEC proliferation (IC50=12.8 and 5.3 μm, respectively). Compound 19g could inhibit the migration of human umbilical vein endothelial cells. These results support the further investigation of these compounds as potent anticancer agents.
Predictors of mortality in patients with non‐anterior ST‐segment elevation myocardial infarction: Analysis from the HORIZONS‐AMI trial
Authors: Huang Xin , Redfors Björn , Chen Shmuel , Gersh Bernard J. , Mehran Roxana , Zhang Yiran , McAndrew Thomas , Ben‐Yehuda Ori , Mintz Gary S. , Stone Gregg W. 
Published: January 2019

AbstractObjectivesWe sought to identify clinical, electrocardiographic (ECG), and angiographic characteristics that are predictive of 3‐year mortality after primary percutaneous coronary intervention (PCI) in patients with non‐anterior ST‐elevation myocardial infarction (NA‐STEMI) from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS‐AMI) trial.BackgroundWhich patients with NA‐STEMI undergoing PCI have a poor prognosis is uncertain.MethodsNA‐STEMI was defined as ST‐segment elevation in lateral (V5, V6, I, aVL), inferior (II, III, aVF), or inferolateral (I, II, III, aVF, and V5‐V6) ECG leads or posterior myocardial infarction with ST‐segment depression of ≥1 mm in ≥2 contiguous anterior leads. Cox regression was used to identify independent predictors of 3‐year mortality. Missing data were imputed using multiple imputation.ResultsIn HORIZONS‐AMI, 2,578/3,602 patients had no prior coronary artery bypass grafting, underwent single‐vessel PCI, and had baseline ECG data assessed in an independent core laboratory. Among them, 1,495 (58.0%) had NA‐STEMI. Patients with NA‐STEMI had lower 3‐year mortality risk than those with anterior STEMI (4.5% versus 7.1%, P = 0.004). The independent predictors of increased 3‐year mortality in NA‐STEMI were older age (median > 59.0 years), diabetes, reduced LVEF (≤50%), Killip class ≥2, post‐procedure TIMI flow 0–2 versus 3, renal insufficiency, and ST‐resolution <30% at 60 min post‐PCI. Patients with 0, 1, 2, 3, and ≥4 of these risk factors had 3‐year mortality rates of 1.8%, 2.3%, 3.1%, 6.1%, and 36.3%, respectively (P < 0.0001).ConclusionsAlthough NA‐STEMI carries a better prognosis than anterior STEMI, high‐risk patient cohorts with NA‐STEMI may be identified who have substantial 3‐year mortality.
Graftmaster savior: Injury to a patent LIMA during pericardiectomy, when a covered stent came to the rescue
Authors: Awuor Stephen O. , Ettinger Steven E. , Capecci Louis M. , Pae Walter E. 
Published: January 2019

AbstractA 71‐year‐old male with multivessel coronary artery disease who underwent bypass with saphenous vein grafts to a Marginal branch and distal RCA and LIMA to LAD in 1988, DM II, atrial fibrillation on Coumadin, TIA, obstructive sleep apnea and pulmonary hypertension was referred to our institution after extensive dyspnea evaluation with a diagnosis of constrictive pericarditis for pericardiectomy. He had normal left ventricular function, moderate mitral and tricuspid regurgitation. Coronary angiography revealed ostial LAD CTO, patent LIMA to mid LAD, second Marginal branch CTO with left‐to‐left collaterals and mid RCA CTO with left‐to‐right collaterals. Vein grafts to the Marginal branch and distal RCA were occluded. The pericardium was heavily calcified on CT of the chest. The LIMA was inadvertently injured leading to acute STEMI and ventricular fibrillation arrest treated with defibrillation once. Surgical repair was unsuccessful. A Graftmaster covered stent was successful deployed with restoration of TIMI III flow to the LAD territory. Pericardiectomy was completed via both the median resternotomy and left thoracotomy. Triple therapy with Aspirin, Clopidogrel, and Coumadin was initiated and maintained for 3 months without hemorrhagic or thrombotic complications. He has continued to do well in follow‐up on Clopidogrel and Coumadin.
Large bore occlusive sheath management
Authors: Kaki Amir , Alraies M. Chadi , Kajy Marvin , Blank Nimrod , Glazier James J. , Mohamad Tamam , Elder Mahir , Schreiber Theodore 
Published: January 2019

AbstractThe field of interventional cardiology has evolved in its ability to carry out complex procedures. Procedures such as transcatheter aortic valve replacement (TAVR), endovascular aneurysm repair (EVAR), and mechanical circulatory support (MCS) devices require large bore access for successful deployment. With the use of large bore‐access, comes with it an increased risk for vascular complications, such as thrombosis and limb ischemia. It is paramount for the interventional cardiologist to know how to manage such complications. In this manuscript, we describe our strategies for the management of occlusive sheaths increasingly encountered with large bore accesses in the upper and lower extremities. Strategies such as peeling away of the introducer sheath and the creation of internal and external bypass circuits are described. By using the described techniques, one can provide prolonged hemodynamic support and maintain large bore sheath access, without jeopardizing perfusion to the extremity.
Exercise‐induced ventricular arrhythmia due to bilateral coronary to pulmonary artery fistulas
Authors: De Roeck Frederic , Franssen Constantijn , De Wolf Daniel , Haine Steven 
Published: January 2019

AbstractIschemic polymorphic ventricular ectopy was documented during exercise testing in a 65‐year‐old Caucasian male patient. Coronary angiogram revealed four coronary to pulmonary artery fistulas (CPAFs) originating from the right and left coronary artery, leading to myocardial ischemia due to steal phenomenon. The three dominant fistulas were coiled percutaneously, while one small fistula was left untreated. During follow‐up, no significant residual ventricular arrhythmia was detected.
Management of a chronic radiation necrosis wound with lyopreserved placental membrane containing viable cells
Authors: Regulski Matthew J. , Danilkovitch Alla , Saunders Molly C. 
Published: January 2019

Key Clinical MessageThis case report describes management of a chronic radiation wound in a patient with multiple comorbidities using a lyopreserved placental membrane containing viable cells (vLPM). Positive outcomes suggest that vLPM provides a good conservative management option for patients with compromised wound healing due to radiation and comorbidities.
Study of the scattering effects on NIR data for the prediction of ash content using EMSC correction factors
Authors: Mancini Manuela , Toscano Giuseppe , Rinnan Åsmund 
Published: January 2019

AbstractScattering effect is a really common physical phenomenon during near‐infrared analysis. It is an undesired variation in the spectral data due to a deviation of light from a straight trajectory into different paths. The nonlinearities introduced can be handled by using spectral preprocessing techniques. The situation is completely different when the parameter of interest is physical by nature, such as ash content, in this case removing the physical artifacts of scattering would be negative for the final model. In this study, we have decided to investigate the ash content parameter trying to figure out if the information useful for its prediction is related to the scattering effects, the chemical features, or a mixture of them. To this aim, two near‐infrared spectral datasets were taken into consideration: woodchip for energy sector and pellet samples for feed sector. A new regression model (CORR‐PLS) was developed by including principal components analysis scores and extended multiplicative scatter correction (EMSC) factors as physical parameters into the partial least squares (PLS) regression model. The prediction performance of the regular PLS models (PLS on the raw data and MSC pre‐treated data) were compared with that of the CORR‐PLS model both with regard to prediction uncertainty and model complexity in order to evaluate which is the relevant information for prediction of the ash content.