bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEG1 indicates poor prognosis and promotes hepatocellular carcinoma invasion, metastasis, and EMT by activating Wnt/β-catenin signaling
Authors: Zhao Yan-rong , Wang Ji-long , Xu Cong , Li Yi-ming , Sun Bo , Yang Lian-yue 
Published: July 2019

Abstract
Heart development protein with EGF-like domains 1 (HEG1) plays critical roles in embryo development and angiogenesis, which are closely related to tumor progression. However, the role of HEG1 in hepatocellular carcinoma (HCC) remains unknown. In the present study, we explored the clinical significance, biological function and regulatory mechanisms of HEG1 in HCC and found that HEG1 is significantly up-regulated in HCC cell lines and primary tumor samples. Additionally, high HEG1 expression is correlated with aggressive clinicopathological features. Patients with high HEG1 expression had shorter overall survival (OS) and disease-free survival (DFS) than those with low HEG1 expression, which indicated that HEG1 is an independent factor for poor prognosis. Lentivirus-mediated HEG1 overexpression significantly promotes HCC cell migration, invasion and epithelial–mesenchymal transition (EMT) in vitro and promotes intrahepatic metastasis, lung metastasis and EMT in vivo. Opposing results are observed when HEG1 is silenced. Mechanistically, HEG1 promotes β-catenin expression and maintains its stability, leading to intracellular β-catenin accumulation, β-catenin nuclear translocation and Wnt signaling activation. Loss- and gain-of-function assays further confirmed that β-catenin is essential for HEG1-mediated promotion of HCC invasion, metastasis and EMT. In conclusion, HEG1 indicates poor prognosis; plays important roles in HCC invasion, metastasis and EMT by activating Wnt/β-catenin signaling; and can serve as a potentially valuable prognostic biomarker and therapeutic target for HCC.
CircRNA-104718 acts as competing endogenous RNA and promotes hepatocellular carcinoma progression through microRNA-218-5p/TXNDC5 signaling pathway
Authors: Yu Jiaze , Yang Minjie , Zhou Bo , Luo Jianjun , Zhang Zihan , Zhang Wen , Yan Zhiping 
Published: July 2019

Abstract
Accumulating evidences indicate that circular RNAs (circRNAs) play a vital role in diverse cancer biology. However, the contributions of circRNAs to hepatocellular carcinoma (HCC) and their underlying mechanism remain largely unknown. The present study aims at investigating the role of circRNA-104718 in HCC progression, which has been observed to be significantly up-regulated in HCC tissues. We found that, higher expression of circRNA-104718 also leds to a poor prognosis in HCC patients. Using luciferase binding assays and RNA immunoprecipitation studies, we identified circRNA-104718 is physically associated and co-expressed with microRNA (miR)-218-5p in HCC. Mechanistically, we demonstrated that circRNA-104718 functions as a competing endogenous RNAs (ceRNAs) and competes with thioredoxin domain-containing protein 5 (TXNDC5) mRNA and directly binds to miR-218-5p. Functionally, we found that ectopically expressed circRNA-104718 accelerated cell proliferation, migration, invasion, and inhibited apoptosis. In vivo studies on a nude mice model showed that circRNA-104718 overexpression could increase the tumor size and the rate of metastasis. Silencing of circRNA-104718 could decrease both the tumor size and metastasis significantly. Conversely, we also observed overexpression of miR-218-5p could in turn decrease the proliferation, migration, invasion, and increase apoptosis. Furthermore, circRNA-104718 could relieve the suppression of miR-218-5p target TXNDC5 and thereby cause an inhibition of miR’s functions. In summary, our results indicate that circRNA-104718 acts as a ceRNA and promotes HCC progression through the targeting of miR-218-5p/TXNDC5 signaling pathway. Thus, we propose that circRNA-104718 would be a promising target for HCC diagnosis and therapy.
Quantum dash frequency comb laser stabilisation by optical self‐injection provided by an all‐fibre based delay‐controlled passive external cavity
Authors: Weber C. , Batagelj B. , Fiala P. , Auth D. , Dragonja U. , Gaimard Q. , Ramdane A. , Breuer S. 
Published: July 2019

The intermode beat frequency stability of a 1 mm long quantum dash self mode‐locked semiconductor laser emitting optical frequency combs centred at 1535 nm is improved by single‐cavity optical self‐injection. A novel all‐fibre based cavity employing a piezo‐stretchable fibre spool provides both macroscopic optical path cavity length of 76 m and microscopic fine‐delay fibre length control. The maximum achieved intermode beat frequency tuning is 2 MHz. The intermode beat frequency line width indicating the optical frequency comb stability is improved from 67 kHz to below 900 Hz constituting an improvement by a factor of 74. An independent free‐space stabilisation experiment and stochastic time‐domain modelling confirm the demonstrated intermode beat frequency tuning range.
SPHERE view of the jet and the envelope of RY Tauri
Authors: Garufi A. , Podio L. , Bacciotti F. , Antoniucci S. , Boccaletti A. , Codella C. , Dougados C. , Ménard F. , Mesa D. , Meyer M. , Nisini B. , Schmid H. M. , Stolker T. , Baudino J. L. , Biller B. , Bonavita M. , Bonnefoy M. , Cantalloube F. , Chauvin G. , Cheetham A. , Desidera S. , D’Orazi V. , Feldt M. , Galicher R. , Grandjean A. , Gratton R. , Hagelberg J. , Lagrange A. M. , Langlois M. , Lannier J. , Lazzoni C. , Maire A. L. , Perrot C. , Rickman E. , Schmidt T. , Vigan A. , Zurlo A. , Delboulbé A. , Le Mignant D. , Fantinel D. , Möller-Nilsson O. , Weber L. , Sauvage J.-F. 
Published: July 2019

Context.Jets are rarely associated with pre-main sequence intermediate-mass stars. This contrasts with the frequent detection of jets in lower mass or younger stars. Optical and near-IR observations of jet-driving sources are often hindered by the presence of a natal envelope.Aims.Jets around partly embedded sources are a useful diagnostic to constrain the geometry of the concealed protoplanetary disk. We intend to clarify how the jet-driving mechanisms are affected by both spatial anisotropies and episodic variations at the (sub-)au scale from the star.Methods.We obtained a rich set of high-contrast VLT/SPHERE observations from 0.6 to 2.2μm of the young intermediate-mass star RY Tau. Given the proximity to the Sun of this source, our images have the highest spatial resolution ever obtained for an atomic jet (down to ~4 au).Results.Optical observations in polarized light show no sign of the protoplanetary disk detected by ALMA. Instead, we observed a diffuse signal resembling a remnant envelope with an outflow cavity. The jet is detected in the Hα, [S II] at 1.03μm, He Iat 1.08μm, and [Fe II] lines in the 1.25μm and 1.64μm. The jet appears to be wiggling and its radial width increasing with the distance is complementary to the shape of the outflow cavity suggesting a strong interaction with jet and envelope. Through the estimated tangential velocity (~100 km s−1), we revealed a possible connection between the launching time of the jet substructures and the stellar activity of RY Tau.Conclusions.RY Tau is at an intermediate stage toward the dispersal of the natal envelope. This source shows episodic increases of mass accretion and ejection similarly to other known intermediate-mass stars. The amount of observed jet wiggle is consistent with the presence of a precessing disk warp or misaligned inner disk that would be induced by an unseen planetary or sub-stellar companion at sub- or few-au scales respectively. The high disk mass of RY Tau and of two other jet-driving intermediate-mass stars, HD 163296 and MWC480, suggests that massive, full disks are more efficient at launching prominent jets.
Massive stars in the young cluster VVV CL074
Authors: Martins F. , Chené A.-N. , Bouret J.-C. , Borissova J. , Groh J. , Ramírez Alegría S. , Minniti D. 
Published: July 2019

Context. The evolution of massive stars is not fully constrained. Studies of young massive clusters hosting various populations of massive stars can help refine our understanding of the life and fate of massive stars.
Aims. In this context, our goal is to study the massive stellar content of the young massive cluster VVV CL074.
Methods. We obtained K-band spectroscopy of the brightest cluster members in order to identify the massive star population. We also determined the stellar properties of the cluster’s massive stars to better quantify the evolutionary sequences linking different types of massive stars. We collected integral field spectroscopy of selected fields in the cluster VVV CL074 with SINFONI on the ESO/VLT. We performed a spectral classification based on the K-band spectra and comparison to infrared spectral atlases. We determined the stellar parameters of the massive stars from analysis with atmosphere models computed with the code CMFGEN.
Results. We uncover a population of 25 early-type (OB and Wolf–Rayet) stars, 19 being newly discovered by our observations out of which 15 are likely cluster members. The cluster’s spectrophotometric distance is 10.2 ± 1.6 kpc, placing it close to the intersection of the galactic bar and the Norma arm, beyond the galactic center. This makes VVV CL074 one the farthest young massive clusters identified so far. Among the massive stars population, three objects are Wolf–Rayet stars, the remaining are O and B stars. From the Hertzsprung–Russell diagram we find that most stars have an age between 3 and 6 Myr according to the Geneva evolutionary tracks. WN8 and WC8-9 stars are the descendants of stars with initial masses between 40 and 60 M⊙. The massive star population of VVV CL074 is very similar to that of the cluster DBS2003-179 and to a lesser extent to that of the Quintuplet cluster, indicating the same age. The central cluster of the Galaxy is ∼3 Myr older. From the comparison of the massive stars populations in these four clusters, one concludes that galactic stars with an initial mass in the range 40–60 M⊙ likely go through a WN8-9 phase.
The Study on Performance of Drag Based Water Turbine under Non-immersive Condition
Authors: Pei Yiting , Mu Zekun 
Published: July 2019

As electricity plays a paramount role in modern life, the electric power outage is always considered to be a serious problem. For this purpose, our research focuses on improving the efficiency of water turbine. By studying the effects of the number and curvature of turbine blades and stimulating water faucet, the water turbine is expected to effectively boost the rotation under non-immersive condition. The goal of the study is to improve the blade design for higher efficiency of the turbine.This project presents the research of performance on drag based water turbine. The water turbine, whose whole structure is exposed in the air, in the research is an alternative for conventional immersed water turbine. The size of the water turbine is relatively small compared with industry size. Incoming water can be from any direction. The water turbine displays certain advantageous perspectives. Following the past experiments about this device, a myriad of developments has made over years. The blades of drag based water turbine have been tested with numerous combinations and permutations; thus, the effective choices of blade curvature decided in the research are one-quarter of a circle, one-third of a circle and half a circle, with the arc lengths and thicknesses to be the same. Besides, the number of blades in different experiments are 2, 3, 4 respectively. The incoming flow rate is expected to be constant, even though it fluctuates between 5.45 LPM and 5.95 LPM because of limited experiment equipment. Effects of blade number and curvature are examined, and corresponding conclusions are made.
Das prä- und postoperative Management von Patienten mit Angle-Klasse-II-Verzahnung, ausgeprägter Spee-Kurve und Tiefbiss in der Dysgnathiechirurgie
Authors: Seeberger Robin 
Published: July 2019

ZusammenfassungDie Dysgnathiechirurgie umfasst Korrekturen des Gesichtsskeletts mit dem Ziel, normale anatomische und funktionelle Verhältnisse wiederherzustellen. Eine besondere Herausforderung sind dabei Patienten mit Angle-Klasse-II-Verzahnung, Tiefbiss und ausgeprägter Spee-Kurve. Eine präoperative Nivellierung der Spee-Kurve gelingt nur über Bisssperrung durch okklusale Aufbauten. Alternativ und bewährt ist die Nivellierung der Spee-Kurve postoperativ. Voraussetzung dafür ist eine stabile 3-Punkt-Abstützung und unmittelbar postoperativ das Einhängen vertikaler Gummizüge zum Schluss des anfangs seitlich offenen Bisses. Anhand eines Fallbeispiels wird das kieferorthopädische und kieferchirurgische Vorgehen verdeutlicht.
Therapie des skelettal anterior frontoffenen Bisses – Aktueller Stand des operativen Vorgehens
Authors: Handschel Jörg , Schneider Oliver , Nienkemper Manuel 
Published: July 2019

ZusammenfassungDer anterior offene Biss (AOB) lässt sich ätiologisch in 3 Gruppen einteilen: 1) der dental AOB, 2) der post-traumatisch AOB und 3) der skeletal AOB.Während beim dentalen AOB und traumatischen AOB therapeutisch sehr häufig gute Langzeitergebnisse erzielt werden, zeichnet sich die skelettale Variante des AOB durch häufige Rezidive aus. Aktuell existieren verschiedene chirurgische Konzepte für die Korrektur dieser Fehlstellung. Im Lichte der aktuellen Literatur und unter Berücksichtigung eigener Untersuchungen und Erfahrungen wird ein chirurgisches Behandlungskonzept plausibilisiert und detailliert beschrieben.
Neuraltherapie bei Nacken- und
Spannungskopfschmerz
Authors: Günter Uwe 
Published: July 2019

ZusammenfassungDie Neuraltherapie ist als diagnostische und therapeutische Anwendung von
Lokalanästhetika beim chronisch-rezidivierenden Nacken- und Spannungskopfschmerz
adjuvant einsetzbar, risikoarm, kostengünstig und erfolgreich.Diese Injektionen werden im Bereich eines jeden schmerzhaften Dermatoms,
verquollenen Subkutoms mit Verbindungen zum perivaskulären Sympathikus,
druckdolenten Faszio-Myotoms (z. B. Triggerpunkt), an Nerven und Ganglien des
Grenzstrang unter standardisiertem Knochenkontakt mit und ohne
Sonographie-Monitoring sowie an Störfeldern wie Tonsillen, Sinus, Zähnen usw.
durchgeführt und kann jeder Arzt erlernen bzw. ambulant und stationär
anwenden.Das Ester Procain ist trotz des Überwiegens der Studien mit Lidocain u. a. Amiden
nach persönlichem Erfahrungsaustausch mit seit mehr als 50 Jahren praktisch
tätigen Autoren und aktuellsten Literaturdaten überlegen bzw. am besten zu
überwachen.
Staged conflicts in Austrian parliamentary debates
Authors: Gruber Helmut 
Published: July 2019

Abstract
This paper analyzes the rhetorical formats used by Austrian members of parliament (MPs) to express disagreement
with previous speakers during the so-called ‘inaugural speech debates’. During these debates, MPs position themselves publicly as
either government or opposition party representatives. Disagreeing with previous debate contributions represents a positioning
practice that focuses on the interpersonal plane of interaction. The strict procedural rules of the debates, however, prevent MPs
from engaging in genuine conflict talk. MPs rather use four rhetorical formats for signalling conflict with a previous speaker.
This paper analyzes these strategies as well as their use by different groups of MPs and discusses their face aggravating/
impoliteness potential. Finally, it relates the results to previous studies of face work in political discourse.
Latin as a tool for social differentiation and epistemic asymmetry
Authors: Orletti Franca 
Published: July 2019

Abstract
The paper aims to present the outcome of a research on the persistence of Latin in Medical Language. The analysis
has been carried out on written and spoken data: clinical records; doctor-patient interactions; prescriptions; package information
leaflets. The study shows that in medical communication Latin is used as a tool for social and epistemic discrimination, to
increase the knowledge gap among professionals and lay people. A different way to reaffirm the voice of medicine against the voice
of life. Our project is inserted in the series of studies dedicated to languages for specific purposes understood not only as
specific vocabularies but mostly as “discursive patterns” that express precise and distinctive professional visions.
‘Inevitable distinctions’
Authors: Saglietti Marzia 
Published: July 2019

AbstractProfessionals working in residential care for children everyday perform the institutional relevant activity of constructing their cases. This article analyzes the ways in which they construct the case of ‘unaccompanied minors’ (UAM) and how, in doing so, they talk into being their everyday practices of work. Drawing on ethnographic interviews with Italian residential care professionals, this study adopts a Discourse Analysis approach. Findings illustrate how the discursive assemblage of UAM relies on participants’ multiple distinctions and on a contrastive rhetoric that is widely used in social work. Differences in the case-construction of UAM mirror participants’ institutional settings and overall socio-cultural debate, paving the way for future investigation.
Responding to customer complaints on English and Polish corporate profiles on Twitter
Authors: Tereszkiewicz Anna 
Published: July 2019

AbstractThe study investigates the strategies used by English and Polish companies in the process of handling customer complaints on Twitter. Since English and Polish are recognized as representatives of negative and positive politeness cultures, respectively, the analysis was to examine if there are differences in politeness conventions in customer-provider interaction on Twitter. The study found that although similar strategies are used by English and Polish companies in responding to complaints, the frequency of the respective strategies is different. The results of the analysis confirm differences in the use of positive and negative politeness strategies as well as differences in the level of directness in interaction between English and Polish profiles.
Epistemic and deontic authority in theargumentum ad verecundiam
Authors: Koszowy Marcin , Walton Douglas 
Published: July 2019

AbstractThe aim of this paper is to elaborate tools that would allow us to analyse arguments from authority and guard against fallacious uses of them. To accomplish this aim, we extend the list of existing argumentation schemes representing arguments from authority. For this purpose, we formulate a new argumentation scheme for argument from deontic authority along with a matching set of critical questions used to evaluate it. We argue that clarifying the ambiguity between arguments from epistemic and deontic authority helps building a better explanation of the informal fallacy of appeal to authority (argumentum ad verecundiam).
Structural, Surface Topography and Optical Characterization of Nanocrystalline MgxZn1-xO Thin Films Grown by Modified Chemical Bath Deposition (SILAR) Method
Authors: Jaafer Mustafa D. , Omran Al-khayatt Adel H. , Saleh Salah M. 
Published: July 2019

Abstract
A series of MgxZn1-xO thin films were grown on glass substrates using modified chemical bath deposition (m-CBD) called successive ionic layer adsorption and reaction (SILAR) technique. The crystal structure, surface topography and the optical characterization of the prepared films were studied as a function of Mg/Zn (x) content. It is observed that the deposited films have polycrystalline structure in nature and grown in two phases Hexagonal and cubic. The preferential orientation of the films was absorbed along (002) plane. Structural parameter such as crystallite size, number of dislocation density and micro-strain were also investigated. The crystallite size and surface roughness are increased with the increase of Mg2+ ions content. Thus the results showed that the surface topography and the surface quality of the deposited films can be controlled by Mg2+ ions content. The optical transmittance spectra analysis showed that transmittance increase with the increase Mg2+ content to about 85% for x = 0.75, and the energy band gap increases (2.82 - 3.17) eV as the Mg2+ content increases x = (0.25 - 0.75). These results indicate that the MgxZn1-xO thin films can be potentially used in high-performance ultraviolet optoelectronic devices.
Synthesis Conditions Of Au Core@ Ag Shell System by Laser Ablation in Distilled Water By Using Different Wavelengths “(1064, 532, 355)”nm
Authors: Al-Daim W A , Al-Dahash G A , Laith Z 
Published: July 2019

Abstract
In this study, an easy and a rapid method has been used to prepare nanoparticles employing the laser ablation technique in Double Distilled Deionized Water (DDDW). Lasers with three different have been used. The laser ablation of a (Au core @ Ag shell) system shows the best ablation at wavelengths of 1064 and 355 nm in DDDW solution with resulting Grain size less than (20 nm).This is the best result for obtaining the size near Quantum Dot (Q.D.) of the Ag @ Au NPS system. The TEM, AFM and statistical distribution of Grain size have been used to analysis morphological properties. The absorption peak shows IR shift for Au @ Ag system, that leads to growth large grains. This indicates that Ag-shell more effective than Au-core at (532,355) nm wavelengths. Some of the optical parameters, such as refractive index (n) and extinction coefficient (k), have been calculated for the prepared nanoparticles collide. TEM shows the formation (Core -Shell) clearly, and the form of NPs can almost have a spherical shape with size < 20 nm. The gold (Au-shell) is more effective than Ag-core.The colloidal nanoparticles have been used as in biological applications to kill or inhibit E. coli and Staph bacteria.
Boron Concentration Measurements in the Samples of Water wells Collected from Al-Diwaniya Governorate -Iraq Using ICP/OES Techniques
Authors: Sweaf Abbas A , Salman Thaer M 
Published: July 2019

Abstract
Boron is not uniformly dispersed, ubiquitous crucial micronutrient component for vegetation as well as for man. The aim of this research is to measure Boron, 10B5, concentration in the water of the wells in Al- Diwaniya governorate in Iraq. The measurements done through analysing the soil samples of wells collected from 30 different locations using ICP/OES Techniques. The Boron concentration, which is obtained from the study, ranged from 0.64 ppm in (Eastern Hamza 4) to 3.81ppm in (Alsuniya 2) in water wells. The findings of the study are introduced and compared with other papers. The findings could be employed to introduce unique supplemental contributions in case a contamination incident happens and to achieve wells water quality standards by related entities to preserve radioactive contamination-free water wells samples, whic are needing for the people. More further, the study discovered that 30 samples of the surface water wells had boron more than detected levels. It is because the higher leaching of boron through monsoon rains from surface water wells beyond the root level. Therefore, in the close future, there will be probability of acute contamination problem with boron.