bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between cardiometabolic index and frailty among patients with diabetes mellitus: a cross-sectional study
Authors: Wei Yi , Yu Jiangyi 
Published: December 2024

BackgroundCardiometabolic index (CMI) is a novel marker that can assess metabolic status. Studies have found that people with diabetes mellitus (DM) are at high risk of developing frailty. However, there is a lack of evidence between CMI and the risk of frailty in patients with DM. Therefore, the aim of this study was to investigate the association between CMI and frailty in patients with DM.MethodsThis study utilized data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). Weighted multivariate logistic regression was conducted in this study to explore the association between CMI and frailty status in patients with DM. In addition, subgroup analyses and interaction analyses were conducted to assess heterogeneity between different subgroups. Subsequently, restricted cubic spline (RCS) was also used to test for non-linear relationships.ResultsThis study ultimately included 2,761 patients with DM. Weighted multivariate logistic regression showed that, after adjusting all covariates, an increase in the level of CMI was associated with an increased risk of being in a frailty status in patients with DM (OR = 1.12, 95% CI = 1.04–1.22, p = 0.005). Dividing CMI into tertiles, the risk of frailty in patients in the highest tertile (Q3) was higher than that of patients in Q1 (OR = 1.56, 95% CI = 1.18–2.07, p = 0.002). The non-linear relationship between CMI and the risk of frailty in DM patients was further confirmed by RCS analysis.ConclusionThis study found that the higher the CMI, the higher the risk of frailty in DM patients. Maintaining a healthy low-fat dietary pattern and properly controlling blood lipid levels may reduce the risk of frailty in patients with DM.
Global research progress of nanomedicine and colorectal cancer: a bibliometrics and visualization analysis
Authors: Tian Siyu , Chen Min 
Published: December 2024

BackgroundSurgery and chemoradiotherapy are the main clinical treatment methods for colorectal cancer (CRC), but the prognosis is poor. The emergence of nanomedicine brings bright light to the treatment of CRC. However, there has not been a comprehensive and systematic analysis of CRC and nanomedicine by bibliometrics.MethodsWe searched the Web of Science Core Collection database (WOSCC) for relevant literature published from 2011 to 2024. We used VOSviewer and Citespace to analyze countries, institutions, authors, keywords, highly cited references, and co-cited references.Results3105 pieces of literatures were included in the research analysis, and PEOPLES R CHINA and the USA took the leading position in the number of papers published and had academic influence. The Chinese Academy of Sciences posted the most papers. The most prolific scholar was Abnous Khalil. The level of economic development is inversely proportional to the number of cases and deaths of colorectal cancer. Nanoparticles (NPs), the nanomedical drug delivery system (NDDS) is a hot topic in the field. Photodynamic therapy (PDT), immunogenic cell death (ICD), tumor microenvironment (TEM), folic acid, and pH are the cutting edge of the field.ConclusionThis paper introduces the research hotspot, emphasis, and frontier of CRC and nanomedicine, and points out the direction for this field.
Difelikefalin in the treatment of hemodialysis patients with pruritus: a systematic review and meta-analysis
Authors: Cai Xiaoyue , Wu Guiming , Lin Yan , Yang Lichuan 
Published: December 2024

Background and ObjectiveUremic pruritus is a persistent condition that is difficult to cure in patients with end-stage renal disease who are having regular dialysis. It is highly prevalent, and current therapies have limited effectiveness and can cause significant adverse effects. Several trials have provided evidence that difelikefalin can be an effective treatment for uremic pruritus, with few side responses. However, it is important to note that the available evidence is limited. This study collected published randomized controlled trials for systematic review and Meta-analysis, to explore the efficacy and safety of difelikefalin treating uremic pruritus and to provide evidence-based medical evidence for clinical treatment.MethodsA systematic literature search was conducted in PubMed, EMBASE, Web of Science, the Cochrane Library Data from building libraries to 6 January 2024. We extracted data from eligible studies to analyze the efficacy and safety of difelikefalin in the treatment of hemodialysis patients with pruritus.ResultsThis study comprised 9 trials with 4,118 people. The meta-analysis demonstrated that difelikefalin is more effective than placebo in treating uremic pruritus. Specifically, difelikefalin resulted in a greater improvement in WI-NRS scores of at least 3 points from baseline (OR = 1.98) and at least 4 points from baseline (OR = 1.94). Additionally, difelikefalin led to a decrease in the total score of the 5-D itch scale (MD = 1.56), a decrease in the skindex-10 scale score (MD = 4.92), and a decrease in the WI-NRS scale score (MD = 0.91).ConclusionDifelikefalin demonstrates significant efficacy in alleviating pruritus in individuals suffering from uremia. Althogh it has adverse events, they are mild.
Characterizing ADRs of Enfortumab vedotin and Erdafitinib in bladder cancer treatment: a descriptive analysis from WHO-VigiAccess
Authors: Huang Yuanbin , Xu Meiqi , Ma Xinmiao , Wang Wei , Shen Chen , Liu Fei , Chen Zhiqi , Wang Jiawen , Guo Qian , Li Xiancheng 
Published: December 2024

IntroductionEnfortumab vedotin (EV) and Erdafitinib are effective therapeutic drugs for bladder cancer patients following post-chemotherapy and immunotherapy. This study assessed adverse drug reactions (ADRs) from both drugs, comparing their safety profiles to guide clinical use.MethodsA retrospective descriptive analysis was conducted on ADR reports for EV and Erdafitinib from the World Health Organization (WHO)-VigiAccess database. Data on patient demographics, system organ classes (SOCs), global patient regions, symptoms, and ADRs frequencies were analyzed and compared.ResultsAs of 2024, 3,438 ADR reports were identified (2,257 for EV and 1,181 for Erdafitinib). The number of adverse reaction reports for EV is significantly higher than that for Erdafitinib. Among them, the SOC with the most adverse signals is gastrointestinal disorders, with the top five reports being nausea, gastrointestinal disorders, dry mouth, abdominal pain, and diarrhea. The top five reported adverse events (AEs) for EV are as follows: skin and subcutaneous tissue disorders (20.70%), general disorders and administration site conditions (14.23%), nervous system disorders (11.12%), gastrointestinal disorders (7.78%), and metabolism and nutrition disorders (6.47%). In contrast, the top five AEs for Erdafitinib are: general disorders and administration site conditions (25.36%), skin and subcutaneous tissue disorders (10.94%), gastrointestinal disorders (10.19%), eye disorders (9.21%), and injury poisoning and procedural complications (7.31%).ConclusionOur study identified and compared potential and novel ADRs between EV and Erdafitinib, providing key insights into their safety profiles and highlighting the need for personalized treatment strategies based on individual patient risk factors.
Seed priming with ascorbic acid and spermidine regulated auxin biosynthesis to promote root growth of rice under drought stress
Authors: Zhang Kangkang , Khan Mohammad Nauman , Khan Zaid , Luo Tao , Zhang Biaojin , Bi Junguo , Hu Liyong , Luo Lijun 
Published: December 2024

IntroductionDrought stress severely hampers seedling growth and root architecture, resulting in yield penalties. Seed priming is a promising approach to tolerate drought stress for stand establishment and root development.MethodsHere, various seed priming treatments, viz., hydro priming, ascorbic acid priming (AsA), and spermidine priming (Spd), were adopted concerning root morphological, physiological, microstructural, and molecular studies under drought stress on rice variety Hanyou 73.Results and discussionResults demonstrated that drought severely suppressed seedling establishment, while AsA or Spd priming effectively alleviated the inhibitory effects of drought stress, and significantly increased shoot length (24.5-27.9%), root length (34.6-38.8%), shoot dry weight (56.1-97.1%), root dry weight (39.6-40.6%), total root length (47.0-57.8%), surface area (77.0-84.9%), root volume (106.5-109.8%), average diameter (16.4-19.7%), and root tips (46.8-61.1%); meanwhile, priming with AsA or Spd alleviated microscopic and ultrastructural damage from root cell, and improved root activity (183.8-192.0%). The mitigating effects of AsA or Spd priming on drought stress were primarily responsible for decreasing the accumulation of reactive oxygen species by increasing antioxidants activities and osmoprotectants contents, which reduced oxidative stress and osmotic cell potential and facilitated improved water and nutrients absorption in roots. Additionally, seed priming with AsA or Spd substantially improved auxin synthesis by upregulating of OsYUC7, OsYUC11 and, OsCOW1 expression. However, there were certain differences in the defense responses of plants and mechanisms of reducing the damage of drought stress after seed treatment with AsA or Spd. Under stress conditions, AsA had a greater impact on improving the fresh and dry weight of aboveground parts, while Spd affected the concentration of total sugar and total protein in plants. Likewise, the degree of oxidative damage was lowered, and POD and CAT activities were elevated due to Spd priming under water-deficient conditions.
Studying political decision-making as a cognitive process: is it interdisciplinary? A bibliometric analysis
Authors: Béchard Benoît , Bodet Marc A. , Laflamme Lydia , Ouimet Mathieu 
Published: December 2024

IntroductionAt the turn of the 21st century, concerns emerged regarding whether research at the intersection of psychology and political science should be regarded as a multidisciplinary subfield within political science or an independent, interdisciplinary field that contributes to both disciplines. More than twenty years later, how does the literature on political decision-making approach this issue? Should this application of political cognition research be viewed as a multidisciplinary subfield within political science, or as an independent interdisciplinary field contributing to both political science and psychology? This study examines the organizational framework of research and the trends in publications within the literature on political decision-making.MethodsThrough a bibliometric analysis, this study aims to enhance readers’ understanding of the disciplinary characteristics of research in political decision-making. The analysis examines how publications are distributed across various disciplines and among different researchers contributing to the study of political decision-making, as well as the most frequently used methodologies in this field.ResultsThe findings suggest that research tends to be more multidisciplinary than strictly interdisciplinary. This conclusion is based on three observations: (i) most publications are in political science journals; (ii) much of the research is conducted by political scientists; and (iii) the research mainly uses political science frameworks and observational designs despite political scientists’ familiarity with experimental designs. Departmental affiliation is the key factor in predicting cited literature, with political scientists favoring political science research and psychologists leaning towards psychology research.DiscussionThe results of this study suggest that while political decision-making research draws on expertise from both disciplines, it remains fundamentally anchored in political science. Recommendations include attending conferences outside the researcher’s primary discipline, provided they are relevant to their research agenda. Researchers should explore the various specialized grants and funding opportunities that aim to promote the development of new research questions and testing new methods, theoretical approaches, and innovative ideas. Faculty should integrate various disciplines into the curriculum to offer valuable and broadly applicable knowledge. By promoting open interdisciplinary dialogue, political scientists and psychology researchers can work together more effectively to tackle the challenges of political decision-making research.
Enigma of social media use: complexities of social media addiction through the serial mediating effects of emotions and self-presentation
Authors: Ho Wing W. Y. , Lau Yan H. Y. , Leung Leona Y. L. , Li Eric K. L. , Ma Reyna K. K. 
Published: December 2024

IntroductionExcessive social media use, though considered unhealthy, is no longer formally categorized as an addiction or disorder, leading to a lack of consensus on this behavior. It raises concerns regarding the exclusion of Internet Addiction Disorder from the DSM-5-TR due to insufficient empirical evidence. This study investigates the serial mediating effects of positive and negative affect, fear of missing out, and offline and online self-presentation in the relationship between social media use and social media addiction.MethodThe study was conducted in Hong Kong with 385 participants (84.2% F, age range = 18–60) of an online survey. This study administered the Social Media Use Scale, Positive and Negative Affect Schedule, Fear of Missing Out Scale, Presentation of Online Self Scale, and Bergen Social Media Addiction Scale.ResultsThe results indicate that social media use plays a significant role in predicting both positive and negative affect. The findings further reveal that positive and negative affect, fear of missing out, and offline and online self-presentation act as serial mediators in the relationship between social media use and social media addiction. In other words, these variables work together in a sequential manner to mediate the impact of social media use on addiction. Additionally, the study indicates that social media use and social media addiction are fully mediated by both positive and negative affect, fear of missing out, and offline and online self-presentation.DiscussionSocial media use can evoke both positive and negative affect. The longer individuals are immersed in social media, the more their positive affect intensifies, exacerbating FoMO and fostering inconsistent offline and online self-presentation. Conversely, extended social media engagement can heighten negative affect, leading to anxiety about others having more rewarding experiences and concurrently inducing apprehension characterized by FoMO. To prevent addiction, the development of educational tools such as SimCity video games, scenario-based learning activities, and virtual reality experiences focused on social media use and social media addiction can offer a valuable opportunity for pre-exposure to the related risks and challenges.
Mortality among individuals with substance use disorder—does violent criminal behavior have an impact?
Authors: Jakobsson Joakim , Karlsson Anna , Håkansson Anders , Hofvander Björn 
Published: December 2024

IntroductionUnderstanding violent criminality and its impact on health and eventually the risk of premature mortality is important for efficient future interventions. This study aimed to explore the effect violent criminality had on premature mortality (i.e., death before the age of 65) among individuals with substance use disorders (SUDs).MethodsThe cohort was created by identifying all Swedish patients diagnosed with SUD between the first of January 2013 and 31st of December 2014. The individuals were split into three age categories.ResultsThere were significant differences in standard mortality rates (SMR) in the cohort compared to the general Swedish population across the three age categories. We found differences between the SMRs for individuals convicted of violent and nonviolent crimes in the two younger age categories [age 15–29: violent crime (42.4) vs. non-violent crime (36.6), age 30–44: violent crime (28.0) vs. non-violent crime (23.0)]. A Cox regression analysis showed that each conviction of a violent crime increased the hazard ratio (HR) of premature mortality significantly [age 15–29; HR = 1.10 (95% CI: 1.04–1.17), age 30–44; HR =1.06 (95% CI: 1.03–1.09)]. After correcting for non-violent crimes, the increased risk only remained for the youngest group [HR = 1.06 (95% CI: 1.00–1.13)].DiscussionThis study suggests that criminal behavior constitutes a proxy for the risk behaviors that increase the risk of premature mortality among young individuals with SUD even after controlling for confounders. Longitudinal studies, examining time-dependent risks and protective influences, are needed to explain the different pathways and processes leading to the amplified premature mortality in the groups.
Spatial distribution of SARS-CoV-2 incidence, social inequality, housing conditions, and density in South-Eastern France: keys for future epidemics
Authors: Mariné Barjoan Eugènia , Prouvost-Keller Bernard , Chaarana Amel , Festraëts Julie , Geloen Carole , Legueult Kevin , Pradier Christian 
Published: December 2024

IntroductionEarly in 2021, the SARS-CoV-2 incidence rate was higher in the East than in the West of the Alpes-Maritimes district in France. What was the impact of social deprivation, household overcrowding and population density per km2 on this difference in incidence rate?MethodsCases were defined as persons with a first SARS-CoV-2 positive test detected between 04/01/2021 and 14/02/2021. We studied the « French Deprivation index » (FDep), rate of overcrowded households and population density/km2. These indicators were compared between East and West and a Standard Incidence Ratio (SIR) and an Incidence Rate Ratio (IRR) were calculated for each indicator. The link between the incidence rate and the socio-economic variables per census blocks (IRIS) was analyzed with a GLM model. Lastly, a stepwise method was used to determine the East/West incidence thresholds for which an association was observed between the incidence rate and these three indicators.ResultsAmong the 473 census blocks, 25,400 cases were geolocated among whom 23,867 not residing in nursing homes nor in long-term communal accommodation. Census blocks in the East included more overcrowded households (p = 0.009) and a higher population density (p &lt; 0.001). In this area, the SARS-CoV-2 incidence was significantly higher in the most deprived census blocks (IRR = 1.614; 95%CI [1.530–1.703]), with a higher rate of overcrowded households (IRR = 1.583; 95%CI [1.508–1.663]) and higher population density (IRR = 1.062; 95%CI [1.023–1.102]). No difference was observed in the West. According to the GLM, in the East, the incidence rate was associated with the FDep index only, while no association was observed in the West. In the East, the association with FDep appeared for an incidence threshold of 210/100,000, while no threshold was identified in the West. Rates of overcrowded households were 310 vs. 370 and population density rates were 260 vs. 400 in the Eastern and Western areas, respectively.ConclusionOur results demonstrate the benefits of conducting a spatial analysis of socio-demographic and medical data. At the start of an emerging infectious agent-related epidemic, while surveillance is not yet operational, initial prevention measures could prioritize targeting populations according to their socio-demographic characteristics.
The impact of meteorological conditions on cardiovascular and cerebrovascular diseases in different microclimatic zones of low-latitude mountainous areas
Authors: Du Zhengjing , Xiong Fang , Tang Yanjing , Xia Xiaoling , Hu Yuandong , Wang Fangfang 
Published: December 2024

IntroductionEpidemiological evidence suggests cerebrovascular disease (CVD) incidence is correlated to meteorological conditions. However, research on the primary meteorological factors influencing the incidence of CVD and their influence thresholds in low-latitude mountainous regions remains insufficient. We aimed to investigate the association between meteorological conditions and CVD occurrence in Guizhou province.MethodsUtilizing daily incidence cases for CVD alongside concurrent meteorological data from four microclimate representative stations in Guizhou Province during 2021-2022, we firstly performed random forest and decision tree analysis to identify the significant meteorological factors influencing the incidence of CVD, and then we applied distributed lag non-linear model (DLNM) to assess the effect of meteorological factors on CVD incidence.ResultsCritical meteorological factors associated with CVD incidence include diurnal temperature range (DTR), temperature change between neighboring days (TCN), diurnal pressure range (DPR), pressure change between neighboring days (PCN), and minimum temperature. The risk of CVD incidence markedly increased with narrow DTR, positive TCN, and colder conditions. The thresholds of minimum temperature and TCN droped with the decrease of annual average temperature in microclimate zone. In the middle subtropical region of Jiangkou, the northern subtropical region of Xishui, and the warm temperate region of Shuicheng, there was a risk of CVD when the minimum temperature falled below 12.2°C, 10.7°C, and 6.7°C, respectively. When TCN exceeded the critical threshold (0.2°C in Shuicheng, 0.3°C in Xishui, and 0.4°C in Jiangkou and Ceheng), the risk of CVD incidence increased linearly. DPR and PCN displayed varied thresholds across different microclimate without consistent patterns. DPR in middle subtropical region of Jiangkou and warm temperate region of Shuicheng played a protective role, while the risk of the disease increased linearly when DPR was lower than 3.2 hPa and 2.7 hPa in south subtropical region of Ceheng and north subtropical region of Xishui, respectively. The short-term effects within 5 days with small DTR and narrow positive TCN were more obvious. The thresholds and lag times of other meteorological environmental factors remained indistinct in the four microclimate zones.DiscussionOur findings delineated the common characteristics of the effect on the incidence of CVD of meteorological environments in various microclimate zones, and clarified the influence of minimum temperature and TCN exhibited spatial heterogeneity, Which may be assistance for meteorological risk forecasting in CVD prevention and control.