bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lasing from Mechanically Exfoliated 2D Homologous Ruddlesden–Popper Perovskite Engineered by Inorganic Layer Thickness
Authors: Liang Yin , Shang Qiuyu , Wei Qi , Zhao Liyun , Liu Zhen , Shi Jia , Zhong Yangguang , Chen Jie , Gao Yan , Li Meili , Liu Xinfeng , Xing Guichuan , Zhang Qing 
Published: August 2019

Abstract2D Ruddlesden–Popper perovskites (RPPs) have aroused growing attention in light harvesting and emission applications owing to their high environmental stability. Recently, coherent light emission of RPPs was reported, however mostly from inhomologous thin films that involve cascade intercompositional energy transfer. Lasing and fundamental understanding of intrinsic laser dynamics in homologous RPPs free from intercompositional energy transfer is still inadequate. Herein, the lasing and loss mechanisms of homologous 2D (BA)2(MA)n−1PbnI3n+1 RPP thin flakes mechanically exfoliated from the bulk crystal are reported. Multicolor lasing is achieved from the large‐n RPPs (n ≥ 3) in the spectral range of 620–680 nm but not from small‐n RPPs (n ≤ 2) even down to 78 K. With decreasing n, the lasing threshold increases significantly and the characteristic temperature decreases as 49, 25, and 20 K for n = 5, 4, and 3, respectively. The n‐engineered lasing behaviors are attributed to the stronger Auger recombination and exciton–phonon interaction as a result of the enhanced quantum confinement in the smaller‐n perovskites. These results not only advance the fundamental understanding of loss mechanisms in both inhomologous and homologous RPP lasers but also provide insights into developing low‐threshold, substrate‐free, and multicolor 2D semiconductor microlasers.
Reversible and Irreversible Modulation of Tubulin Self‐Assembly by Intense Nanosecond Pulsed Electric Fields
Authors: Chafai Djamel Eddine , Sulimenko Vadym , Havelka Daniel , Kubínová Lucie , Dráber Pavel , Cifra Michal 
Published: August 2019

AbstractTubulin self‐assembly into microtubules is a fascinating natural phenomenon. Its importance is not just crucial for functional and structural biological processes, but it also serves as an inspiration for synthetic nanomaterial innovations. The modulation of the tubulin self‐assembly process without introducing additional chemical inhibitors/promoters or stabilizers has remained an elusive process. This work reports a versatile and vigorous strategy for controlling tubulin self‐assembly by nanosecond electropulses (nsEPs). The polymerization assessed by turbidimetry is dependent on nsEPs dosage. The kinetics of microtubules formation is tightly linked to the nsEPs effects on structural properties of tubulin, and tubulin‐solvent interface, assessed by autofluorescence, and the zeta potential. Moreover, the overall size of tubulin assessed by dynamic light scattering is affected as well. Additionally, atomic force microscopy imaging reveals the formation of different assemblies reflecting applied nsEPs. It is suggested that changes in C‐terminal modification states alter tubulin polymerization‐competent conformations. Although the assembled tubulin preserve their integral structure, they might exhibit a broad range of new properties important for their functions. Thus, these transient conformation changes of tubulin and their collective properties can result in new applications.
Bulk and Few‐Layer 2D, p‐MnPS3 for Sensitive and Selective Moisture Sensing
Authors: Kumar Rajat , Jenjeti Ramesh Naidu , Sampath Srinivasan 
Published: August 2019

AbstractIn this study, the humidity sensing properties of two dimensional (2D), few‐layer p‐MnPS3 is explored. Few‐layer of p‐MnPS3 is obtained by exfoliating highly oriented bulk crystals and assembled as thin films on various substrates. The performance of p‐MnPS3 thin film sandwiched between two similar metal electrodes (Ag or Au) toward various levels of moisture under ambient conditions is investigated. The results depict that p‐MnPS3 nanosheets based humidity sensors are highly sensitive and show fast response and recovery times with good repeatability. It is observed that the resistance of the films decreases five to six orders of magnitude with a change in relative humidity (RH) from 0% to 98%. A fast response time of ≈1–2 s and recovery time of ≈4 s are observed. The mechanism of sensing is understood based on AC impedance spectroscopy. Extrinsic mechanism such as filamentary conduction is ruled out based on the data obtained using devices with different channel lengths. Ionic conduction within the channel is mainly responsible for the observed increase in conductivity in presence of moisture. The humidity sensors are shown to be effective in monitoring human respiration as well as water evaporation on skin without physical contact.
Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion
Authors: Mi Yu , Yang Feifei , Bloomquist Cameron , Xia Youli , Sun Bo , Qi Yanfei , Wagner Kyle , Montgomery Stephanie A. , Zhang Tian , Wang Andrew Z. 
Published: August 2019

AbstractPeritoneal adhesion occurs in a majority of patients following abdominal surgery and can result in significant side effects and complications. Current strategies to minimize adhesions involve the use of nontargeted anatomical barriers that are either inefficient in protecting injured areas or lacking the adequate residence time to prevent adhesions. Herein, the development of a biologically targeted photo‐crosslinkable nanopatch (pCNP) is reported that can prevent postsurgical adhesion. It is demonstrated that pCNP can form a compact protective barrier over surfaces with exposed collagen IV. Using a rat parietal peritoneal excision adhesion model, it is showed that pCNP is highly effective and safe in preventing postsurgical adhesions. This work presents a novel approach to preventing peritoneal adhesion with nanomaterials.
Biallelic and De Novo Variants in DONSON Reveal a Clinical Spectrum of Cell Cycle‐opathies with Microcephaly, Dwarfism and Skeletal Abnormalities
Authors: Karaca Ender , Posey Jennifer E. , Bostwick Bret , Liu Pengfei , Gezdirici Alper , Yesil Gozde , Coban Akdemir Zeynep , Bayram Yavuz , Harms Frederike L. , Meinecke Peter , Alawi Malik , Bacino Carlos A. , Sutton V. Reid , Kortüm Fanny , Lupski James R. 
Published: August 2019

AbstractCo‐occurrence of primordial dwarfism and microcephaly together with particular skeletal findings are seen in a wide range of Mendelian syndromes including microcephaly micromelia syndrome (MMS, OMIM 251230), microcephaly, short stature, and limb abnormalities (MISSLA, OMIM 617604), and microcephalic primordial dwarfisms (MPDs). Genes associated with these syndromes encode proteins that have crucial roles in DNA replication or in other critical steps of the cell cycle that link DNA replication to cell division. We identified four unrelated families with five affected individuals having biallelic or de novo variants in DONSON presenting with a core phenotype of severe short stature (z score < −3 SD), additional skeletal abnormalities, and microcephaly. Two apparently unrelated families with identical homozygous c.631C > T p.(Arg211Cys) variant had clinical features typical of Meier‐Gorlin syndrome (MGS), while two siblings with compound heterozygous c.346delG p.(Asp116Ile*62) and c.1349A > G p.(Lys450Arg) variants presented with Seckel‐like phenotype. We also identified a de novo c.683G > T p.(Trp228Leu) variant in DONSON in a patient with prominent micrognathia, short stature and hypoplastic femur and tibia, clinically diagnosed with Femoral‐Facial syndrome (FFS, OMIM 134780). Biallelic variants in DONSON have been recently described in individuals with microcephalic dwarfism. These studies also demonstrated that DONSON has an essential conserved role in the cell cycle. Here we describe novel biallelic and de novo variants that are associated with MGS, Seckel‐like phenotype and FFS, the last of which has not been associated with any disease gene to date.
A Nitrogen‐Doped Hexapole [7]Helicene versus Its All‐Carbon Analogue
Authors: Guo Xiaoyu , Yuan Ziyong , Zhu Yanpeng , Li Zhihao , Huang Ruikang , Xia Zeming , Zhang Weixiong , Li Yang , Wang Jiaobing 
Published: August 2019

AbstractTwo synthetic nanographenes (NGs),N‐H7HandC‐H7H, were prepared.N‐H7His doped with nitrogen, andC‐H7His the all‐carbon analogue. Both are hexapole [7]helicenes (H7Hs), and their structures were identified by single‐crystal X‐ray diffraction. Sharp contrasts in absorption (absλmax, 683 vs. 593 nm), emission (emλmax, 894 vs. 777 nm), and electrochemical behavior (oxE1, 0.28 vs. 0.53 V) were observed betweenN‐H7HandC‐H7H, and the origin of these differences was rationalized by theoretical calculations. Studies onN‐H7HandC‐H7Hset a clear example to elucidate the remarkable effects of N‐doping on the physical properties of NGs.
Cellulose hydrogels physically crosslinked by glycine: Synthesis, characterization, thermal and mechanical properties
Authors: Palantöken S. , Bethke K. , Zivanovic V. , Kalinka G. , Kneipp Janina , Rademann Klaus 
Published: August 2019

ABSTRACTBiopolymers are very efficient for significant applications ranging from tissue engineering, biological devices to water purification. There is a tremendous potential value of cellulose because of its being the most abundant biopolymer on earth, swellability, and functional groups to be modified. A novel, highly efficient route for the fabrication of mechanically stable and natural hydrogels is described in which cellulose and glycine are dissolved in an alkaline solution of NaOH and neutralized in an acidic solution. The dissolving temperature and the glycine amount are essential parameters for the self‐assembly of cellulose chains and for tuning the morphology and the aggregate structures of the resulting hydrogels. Glycine plays the role of a physical crosslinker based on the information obtained from FTIR and Raman spectra. Among the prepared set of hydrogels, CL5Gly30 hydrogels have the highest capacity to absorb water. The prepared CL5Gly30 gels can absorb up to seven times their dry weight due to its porous 3‐D network structure. CL5Gly10 hydrogel exhibits 80% deformation under 21 N force executed. The method developed in this article can contribute to the application of heavy metal adsorption in aqueous solutions for water purification and waste management. © 2019 The Authors. 137 published by Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48380.
Design, synthesis, biological evaluation, and molecular modeling studies of rhodanine derivatives as pancreatic lipase inhibitors
Authors: Chauhan Divya , George Ginson , Sridhar S. N. C. , Bhatia Rohit , Paul Atish T. , Monga Vikramdeep 
Published: August 2019

AbstractA series of rhodanine‐3‐acetic acid derivatives were synthesized via Knoevenagel condensation of rhodanine‐3‐acetic acid with various substituted aromatic aldehydes. The synthesized derivatives were screened in vitro for understanding the inhibitory potential towards pancreatic lipase (PL), a key enzyme responsible for the digestion of dietary fats. Derivative 8f exhibited a potential inhibitory activity towards PL (IC50 = 5.16 µM), comparable to that of the standard drug, orlistat (0.99 µM). An increase in the density of the aromatic ring resulted in potential PL inhibition. The enzyme kinetics of 8f exhibited a reversible competitive‐type inhibition, similar to that of orlistat. Derivative 8f exhibited a MolDock score of ‐125.19 kcal/mol in docking studies, and the results were in accordance with their PL inhibitory potential. Furthermore, the reactive carbonyl group of 8f existed at a distance adjacent to Ser152 (≈3 Å) similar to that of orlistat. Molecular dynamics simulation (10 ns) of the 8f‐PL complex revealed a stable binding conformation of 8f in the active site of PL (maximum root mean square displacement of ≈2.25 Å). The present study identified novel rhodanine‐3‐acetic acid derivatives with promising PL inhibitory potential, and further lead optimization might result in potent PL inhibitors.
Nickel‐Catalyzed Chemoselective Acetalization of Aldehydes With Alcohols under Neutral Conditions
Authors: Subaramanian Murugan , Landge Vinod G. , Mondal Akash , Gupta Virendrakumar , Balaraman Ekambaram 
Published: August 2019

AbstractA molecularly defined NiII‐complex catalyzing the chemoselective acetalization of aldehydes with alcohols under neutral conditions is reported. The reaction is general, efficient and showed a wide substrate scope (including aliphatic aldehydes) as well as excellent functional group tolerance. Reusability of the present nickel catalyst is also demonstrated.
How Much Knowledge is Worth Knowing? An American Intellectual Historian's Thoughts on theGeschichte des Wissens
Authors: Marchand Suzanne 
Published: August 2019

AbstractThis essay investigates the origins and assesses the advantages and disadvantages of the new field known asWissensgeschichtefrom the perspective of an American intellectual historian. It argues that while some historians of science may be ready to embrace a new identity ashistorians of knowledge, this terminology remains baggy and invites facile applications of Foucauldian theory. The essay concludes with the hope that thehistory of knowledgeapproach may instead open up new avenues for conversation and collaboration between historians of science and garden variety historians.
Treatment duration as a surrogate endpoint to evaluate the efficacy of crizotinib in sequential therapy for patients with advanced ALK‐positive non‐small cell lung cancer: A retrospective, real‐world study
Authors: Yang Guangjian , Ma Di , Xu Haiyan , Yang Lu , Li Junling , Xing Puyuan , Hao Xuezhi , Wang Yan 
Published: August 2019

AbstractObjectivesCrizotinib has demonstrated good efficacy in patients with anaplastic lymphoma kinase (ALK)‐positive non‐small cell lung cancer (NSCLC). Continuing crizotinib therapy beyond progressive disease (CBPD) can achieve ongoing survival benefit in real‐world clinical practice. In terms of survival, progression‐free survival (PFS), the most commonly used endpoint in efficacy evaluations, may not provide accurate information on the impact of this intervention when crizotinib is administered in sequential therapy.Materials and MethodsA single‐center, retrospective study of 201 ALK‐positive advanced NSCLC patients was conducted to analyze the PFS, overall survival (OS), and treatment duration (TD) of crizotinib. The correlations between the TD of crizotinib and OS in CBPD and non‐CBPD groups of patients were compared.ResultsAll patients were treated with crizotinib, 150 of whom eventually developed progressive disease (PD). The median PFS1 and PFS2 were 13.2 months and 10.5 months, respectively. The OS of the whole population was 50.5 months. The median TD was 20.7 months, which is shorter than direct PFS1 + PFS2. The TD of crizotinib in CBPD group was significantly longer than that in non‐CBPD group (median 39.7 vs 15.0 months, P < .001). TD correlated better with OS (R = .79) than PFS (R = .64) in the CBPD group.ConclusionsCrizotinib showed good efficacy in patients with ALK‐positive advanced NSCLC. Instead of PFS, treatment duration might be a more reasonable surrogate clinical endpoint in patients who received crizotinib in sequential therapy.
Prognostic significance of laterality in renal cell carcinoma: A population‐based study from the surveillance, epidemiology, and end results (SEER) database
Authors: Guo Shengjie , Yao Kai , He Xiaobo , Wu Shulin , Ye Yunlin , Chen Junxing , Wu Chin‐Lee 
Published: August 2019

AbstractBackgroundVarious prognostic characteristics have been established in the renal cell carcinoma (RCC). However, the impact of tumor laterality is unknown. The objective of the current study was to explore the predictive and prognostic impact of tumor laterality of RCC after surgery.MethodsThis investigation was a population‐based retrospective cohort study of patients with RCC from the surveillance, epidemiology, and end results (SEER) database in the USA. All patients received surgical treatment between January 2010 and December 2014. Cancer‐specific survival (CSS) measured from the time of surgery.ResultsThis study identified 41 138 surgically treated RCC patients: Of these patients, 50.6% had right‐sided RCC, 59.5% were younger than 65 years of age, 63.8% were male, and 81.0% were Caucasian. The stage distribution was 67.0% (I), 9.5% (II), 17.1% (III), and 6.4% (IV). Patients with right‐sided RCC were more likely to have favorable clinicopathological features compared with patients with left‐sided RCC. In adjusted analyses, patients with right‐sided RCC showed significantly better CSS than those with left‐sided RCC within different subgroups including tumor size ≥10 cm (P = .004), age <65 years (P = .002), male gender (P = .001), Caucasian race (P = .001), clear cell carcinoma type (P = .024), and radical nephrectomy (P = 0.008). Moreover, in the subgroup of tumor size ≥10 cm, right‐sided cancer was an independent predictor of CSS (P = .022).ConclusionRight‐sided RCC is associated with more early‐stage, low‐grade disease and shows better CSS than left‐sided RCC. Moreover, laterality remained as an independent prognostic factor for cancer‐specific survival in subgroup of tumor size ≥10 cm RCC.
Cognitive and motor aspects of cancer‐related fatigue
Authors: Feng Li Rebekah , Regan Jeniece , Shrader Joseph A. , Liwang Josephine , Ross Alexander , Kumar Saloni , Saligan Leorey N. 
Published: August 2019

AbstractBackgroundCancer‐related fatigue (CRF) is a debilitating symptom frequently reported by patients during and after treatment for cancer. CRF is a multidimensional experience and is often solely assessed by self‐report measures. The goal of the study is to examine the physical and cognitive aspects of self‐reported CRF using a cognitive function test and a physical fatigue index in order to provide objective measures that can characterize the CRF phenotype.MethodsA total of 59 subjects with nonmetastatic prostate cancer receiving external beam radiation therapy were included in the study. Fatigue was measured using the Functional Assessment of Cancer Therapy‐Fatigue (FACT‐F) questionnaire. Cognitive characteristics of CRF was measured using the Stroop Color‐Word Interference computerized test and the motor aspect of fatigue was measured using the static fatigue test using a handgrip dynamometer.FindingsFunctional Assessment of Cancer Therapy‐Fatigue scores significantly correlated with the Stroop Interference score, but not performance accuracy in all test conditions. Fatigued subjects exhibited a more rapid decline to 50% of maximal strength and increased static fatigue index in the handgrip test, whereas maximal grip strength was not affected.ConclusionsThe results suggest that CRF exhibits both cognitive and physical characteristics. Subjective fatigue was associated with increased time required to overcome cognitive interference, but not cognitive performance accuracy. Fatigued patients exhibited decreased physical endurance and the ability to sustain maximal strength over time. These objective measures may serve as valuable tools for clinicians to detect cognitive and physical impairment associated with CRF.
Patients' prognosis of intrahepatic cholangiocarcinoma and combined hepatocellular‐cholangiocarcinoma after resection
Authors: Song Peipei , Midorikawa Yutaka , Nakayama Hisashi , Higaki Tokio , Moriguchi Masamichi , Aramaki Osamu , Yamazaki Shintaro , Aoki Masaru , Teramoto Kenichi , Takayama Tadatoshi 
Published: August 2019

AbstractCombined hepatocellular‐cholangiocarcinoma (cHCC‐CC) and intrahepatic cholangiocarcinoma (ICC) are classified into one category, but comparison of prognosis of the two carcinomas remains controversial. The aim of the current study was to investigate surgical outcomes for patients with ICC or cHCC‐CC who underwent resection in order to elucidate whether the classification of ICC and cHCC‐CC is justified. Subjects were 61 patients with ICC and 29 patients with cHCC‐CC who underwent liver resection from 2001 to 2017. Clinic‐pathological data from the two groups were compared. Tumor number and vascular invasion were independent risk factors for recurrence‐free survival (RFS) in both groups (P < .001 for both). Of note, for patients with ICC, tumor cut‐off size of 5 cm showed statistical significance in median RFS (>5 cm vs ≤5 cm, 0.5 years vs 4.0 years, P = .003). For patients with cHCC‐CC, tumor cut‐off size of 2 cm showed statistical significance in median RFS (>2 cm vs ≤2 cm, 0.6 years vs 2.6 years, P = .038). The median RFS of patients with cHCC‐CC was 0.9 years (95% confidence interval: 0.3‐1.6), which was poorer than that of patients with ICC (1.3 years, 0.5‐2.1) (P = .028); the rate of RFS at 5 years was 0% and 37.7% respectively. Our study supports the concept of classifying ICC and cHCC‐CC into different categories because of a significant difference in RFS between the two.
Risk of cancer and longest‐held occupations in Japanese workers: A multicenter hospital‐based case‐control study
Authors: Kaneko Rena , Zaitsu Masayoshi , Sato Yuzuru , Kobayashi Yasuki 
Published: August 2019

AbstractObjectivesLittle is known about the risk of developing various cancers according to occupation and occupational physical activity.MethodsUsing nationwide clinical inpatient data (1984‐2017) in Japan, we undertook a multicentered, matched case‐control study with regard to the risk of developing various cancers according to occupation and using patients admitted with fractures as controls. Using standardized national occupation and industrial classifications, we first identified the longest‐held job for each patient. Using sales workers as the reference group, odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by conditional logistic regression, adjusted for age, admission period, and the admitting hospital, with smoking, alcohol consumption, and lifestyle diseases as covariates. The risk of high and low occupational physical activity was also estimated.ResultsAcross all occupations, a reduced risk for all common cancers among males was observed among those occupations associated with high physical activities, such as agriculture. People in these occupations tended to show a lower risk for most cancers, including, for example, prostate cancer (OR 0.58, 95% CI 0.45‐0.75) and lung cancer (OR 0.63, 95% CI 0.51‐0.76). For females, the breast cancer risk was low in women engaged in agriculture (OR 0.58, 95% CI 0.45‐0.75) and in those occupations with high levels of occupational physical activity (OR 0.58, 95% CI 0.52‐0.66).ConclusionsThis study revealed differences in cancer risk among diverse occupations in Japan. Specifically, those occupations associated with high levels of physical activity may be associated with a decreased risk of cancer.