bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic Challenges
Authors: Harahap Agnes Stephanie , Ham Maria Francisca , Kurniawan Andree , Charles Stefanny , Wijovi Felix , Sukrisman Lugyanti 
Published: November 2024

PURPOSE
The global burden of lymphoma is substantial because of the increase in its incidence in recent decades. However, disease characteristics vary across different geographical locations. Numerous immunohistochemistry markers and molecular studies are essential to determine lymphoma diagnosis and prognosis. This poses significant challenges in developing countries with limited health care resources. This large-scale study assesses the frequency of non-Hodgkin lymphoma (NHL) in Indonesia over the past 15 years, analyses its clinicopathologic features, and predicts future trends.

METHODS
This retrospective study collected lymphoma patients diagnosed at the Department of Anatomical Pathology Dr. Cipto Mangunkusumo National Central General Hospital, Indonesia, from 2009 until 2023. All lymphoma diagnoses were confirmed by using ancillary tools classified as an enhanced lymphoma panel according to a resource-stratified guideline. We analyzed the clinicopathologic features of each NHL type and further applied the Autoregressive Integrated Moving Average model to predict future incidence trends.

RESULTS
The study consisted of 7,368 NHL patients. Among these, B-cell lymphomas accounted for 90.6%, with diffuse large B-cell lymphoma being the most prevalent subtype (68.8%), followed by follicular lymphoma (8.8%) and marginal zone lymphoma (5.8%). Extranodal natural killer/T-cell lymphoma, nasal type, is the most common T-cell lymphoma found (26.3%). All types of lymphoma were found to be more common in males (57.7%). Extranodal involvement, particularly in the tonsil and upper respiratory tract, was frequently observed. Projection analysis indicates a steady increase in lymphoma patients in the future.

CONCLUSION
This study highlights the distribution and burden of NHL in Indonesia over 15 years. The overall epidemiologic pattern of NHL in this study aligns with the results observed in other Asian countries. The rising incidence of lymphoma requires improved health care infrastructure and prevention strategies.
Assessment of the Clinicopathologic Characteristics and Survival Rates of Colorectal Cancer Among Syrian Refugees and Turkish Population in Gaziantep Province
Authors: Karan Canan , Okten İlker Nihat , Kesen Oğuzhan , Çelikyürek Atalay , Teker Fatih , Yalçın Şuayib 
Published: November 2024

PURPOSE
Syrian refugees (SRs) have had difficulties in the diagnosis, treatment, and follow-up of chronic diseases, such as cancer, because of the conflict in the region. The cancer diagnosis and treatment process of SR are also a matter of curiosity. We aimed to compare the demographic characteristics and survival outcome data of SRs and Turkish citizens (TCs), and colorectal cancer (CRC) is one of the most common cancer types seen with similar frequency globally.

MATERIALS AND METHODS

A total of 421 patients with CRC were included. Overall survival (OS) was estimated using the Kaplan-Meier method, and the log-rank test was used for comparison. Patient demographic data were compared using the Pearson Chi-square test and independent
t
test.

RESULTS

In total, 421 patients (282 TCs and 139 SRs) were included in this study. The mean age was 52.9 ± 14.3 years for the entire population: 55.3 ± 14.1 years for TCs and 47.9 ± 13.4 years for SRs. Forty (29%) SRs and 60 (21.4%) TCs had de novo metastatic disease (
P
= .08). The median OS in the general population was 57.9 months (95% CI, 40.1 to 75.7), whereas it was 80.9 months (95% CI, 56.5 to 97.2) in TCs and 42.2 months in SRs (95% CI, 27.0 to 57.4;
P
= .006). In the nonmetastatic group, the median OS did not reach (NR) in TCs, and it was 52.6 months (95% CI, 43.7 to 61.5) in SRs (
P
= .02). In the metastatic group, the median OS was 21 months (95% CI, 8.5 to 29.2) in TCs, and it was 18.9 months in SRs (95% CI, 16.3 to 25.7;
P
= .93).

CONCLUSION
The survival rate was lower in the SR group. Since CRC is also common among refugees, developing and implementing methods to improve the welfare of vulnerable populations is necessary.
Updated Survival Follow-Up for Phase Ib Trial of the Histone Deacetylase Inhibitor Abexinostat With Pazopanib in Patients With Solid Tumor Malignancies
Authors: Tsang Erica S. , Aggarwal Rahul R. , Bergsland Emily K. , Calabrese Susan , Rozie Alexandrine , Chaudhuri Sibapriya , Dhawan Mallika S. , Pawlowska Nela , Grabowsky Jennifer , Thomas Scott , Munster Pamela N. 
Published: November 2024

PURPOSE
Histone deacetylase (HDAC) inhibition downregulates hypoxia-inducible factor-1α and modulates multiple metabolomic pathways relevant in cancer. Here we report a potential novel biomarker to predict exceptional responders (>3 years) in patients receiving HDAC and vascular endothelial growth factor (VEGF) inhibition.

PATIENTS AND METHODS
Patients with solid tumor malignancies were enrolled in this phase Ib trial of abexinostat (4/7 ×21 days) and pazopanib (28/28 days), with a dose expansion in renal cell carcinoma (RCC). Plasma was analyzed for metabolomics and peripheral blood mononuclear cells (PBMCs) for VEGF and HDAC2 expression levels.

RESULTS

Fifty-one patients were enrolled: n = 36 patients in dose escalation and n = 15 in dose expansion. After the initial report in 2017, six patients had remained on study: four with RCC and one each with medullary thyroid and thymic neuroendocrine carcinoma. One patient with RCC remains on treatment for >11 years after progression on five systemic therapies. Overall, the median duration of therapy measured 5.6 (1-133) months. The median duration of therapy in exceptional responders measured 44.1 (39.8-133+) months. The median overall survival in patients with high PBMC HDAC2 expression versus low HDAC2 was 32.3 versus 9.2 months (
P
= .004) for all patients and 43.3 versus 25.1 months for patients with RCC (
P
= .09). Exceptional responders had lower kynurenine levels both pre- and post-treatment (
P
= .002,
P
< .001, respectively). HDAC2 and kynurenine expression levels were inversely correlated (
P
= .02).

CONCLUSION
Abexinostat added to pazopanib shows extended tolerability and long-term responses and survival. PBMC HDAC2 levels, the abexinostat target, are relevant predictors of response. In addition, metabolomic assessment points to kynurenine as a predictor for exceptional response to combined VEGF plus HDAC inhibition.
KRASG12D-Mutated Metastatic Colorectal Cancer: Clinical, Molecular, Immunologic, and Prognostic Features of a New Emerging Targeted Alteration
Authors: Moretto Roberto , Rossini Daniele , Murgioni Sabina , Ciracì Paolo , Nasca Vincenzo , Germani Marco Maria , Calegari Maria Alessandra , Vetere Guglielmo , Intini Rossana , Taravella Ada , Studiale Vittorio , Boccaccio Chiara , Passardi Alessandro , Tamburini Emiliano , Zaniboni Alberto , Salvatore Lisa , Pietrantonio Filippo , Lonardi Sara , Masi Gianluca , Cremolini Chiara 
Published: November 2024

PURPOSE
KRASG12D mutation (mut) occurs in about 10%-12% of metastatic colorectal cancer (mCRC). Recently, novel KRASG12D inhibitors have been developed and are currently under investigation in phase I/II clinical trials in solid tumors including mCRC. We aimed at performing a comprehensive characterization of clinical, molecular, immunologic, and prognostic features of KRASG12D-mutated mCRC to inform the design and the interpretation of future trials.

METHODS
We performed a pooled analysis of phase III TRIBE and TRIBE2 studies comparing 5-fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI)/bevacizumab (bev) to doublets (5-fluorouracil, leucovorin, and oxaliplatin or 5-fluorouracil, leucovorin, and irinotecan)/bev.

RESULTS

One hundred and thirty-six (16%) of 854 patients with available KRASG12D mutational status were KRASG12D mutated. KRASG12D-mutated patients had more frequently right-sided primary tumor and were less likely to present liver-only metastases with respect to other RAS mutated and all-wild-type (wt) patients. Compared with the BRAFV600E-mutated group, KRASG12D-mutated patients had more frequently left-sided primary tumor, resected primary tumor at the time of diagnosis, and Eastern Cooperative Oncology Group performance status 0. KRASG12D-mutated patients had better prognosis than BRAFV600E-mutated and worse prognosis than all wt patients. No prognostic difference was evident between KRASG12D mut and other
RAS
mut patients overall or according to other specific
KRAS
or
NRAS
hotspot mutations. No interaction effect was observed between KRASG12D mut and the benefit provided by FOLFOXIRI/bev compared with doublets/bev.
PIK3CA
mut were reported more frequently among KRASG12D-mutated tumors compared with both other
RAS
mut and all wt.

CONCLUSION
A detail estimation of KRASG12D mut mCRC patients' characteristics and expected outcomes may be useful when planning future studies in this subgroup. The high prevalence of PI3K/PTEN/Akt pathway activating alterations may affect the efficacy of targeted strategies.
Navigated Transcranial Magnetic Stimulation and Diffusion Tensor Imaging Tractography in Insular Glioma Surgery
Authors: Denker Maren , Picht Thomas , Engelhardt Melina , Dengler Nora F. , Vajkoczy Peter , Zdunczyk Anna 
Published: November 2024

BACKGROUND AND OBJECTIVES:
The surgical resection of insular gliomas is associated with a high rate of postoperative morbidity as they grow close to descending motor fibers and lenticulostriate arteries. It is believed that intraoperative perforator infarctions are the determining factor for patients' postoperative outcome, while the majority of patients with intraoperative ischemic events do not develop postoperative motor deficits. This study aims to evaluate whether navigated transcranial magnetic stimulation (nTMS) and nTMS-based fiber tracking could be valuable for the preoperative assessment of patients with insular gliomas.

METHODS:
Thirty-two patients with insular gliomas were presurgically examined by nTMS. The resting motor threshold and cortical representation areas of legs, hands, and face were identified on both hemispheres. Motor evoked potential positive stimulation points were then used as a region of interest for diffusion tensor imaging tractographies. Somatotopic fiber tracking was performed enabling analyses of the spatial relation between tumor and cortico-spinal tract (CST) as well as the extraction of fiber tract integrity, measured by fractional anisotropy and the apparent diffusion coefficient.

RESULTS:
The performance of nTMS mappings of the motor cortex and reconstruction of descending motor fibers for legs, hands, and facial functioning was successful in all patients. Higher preoperative resting motor threshold ratios and a distance between tumor and CST of <3 mm were associated with a permanent deterioration in motor function (P = .029 and P = .007). Shorter distances between CST and tumorous tissue were correlated with lowered peritumoral fractional anisotropy values, suggesting alterations in fiber tract integrity. Lower interhemispheric peritumoral fractional anisotropy ratios showed an association with new postoperative motor deficits (P = .017).

CONCLUSION:
nTMS-based diffusion tensor imaging tractography enables somatotopic tract visualization and provides a valuable tool for preoperative planning, intraoperative orientation, and individual risk stratification. Thus, it may be beneficial to increase safety in insular glioma resection surgery.
Slc26a2-mediated sulfate metabolism is important in tooth development
Authors: Yoshida Yuka , Inubushi Toshihiro , Yokoyama Mika , Nag Priyanka , Sasaki Jun-ichi , Oka Ayaka , Murotani Tomoya , Kani Renshiro , Shiraishi Yuki , Kurosaka Hiroshi , Takahata Yoshifumi , Nishimura Riko , Imazato Satoshi , Papagerakis Petros , Yamashiro Takashi 
Published: November 2024

ABSTRACT
The sulfate transporter gene SLC26A2 is crucial for skeletal formation, as evidenced by its role in diastrophic dysplasia, a type of skeletal dysplasia in humans. Although SLC26A2-related chondrodysplasia also affects craniofacial and tooth development, its specific role in these processes remains unclear. In this study, we explored the pivotal roles of SLC26A2-mediated sulfate metabolism during tooth development. We found that Slc26a2 was predominantly expressed in dental tissues, including odontoblasts and ameloblasts. Slc26a2 knockout (Slc26a2-KO-Δexon2) mice exhibited distinct craniofacial abnormalities, such as a retrognathic upper jaw, small upper incisors and upper molar hypoplasia. These mice also showed flattened odontoblasts and loss of nuclear polarity in upper incisors and molars, with significant reductions in odontoblast differentiation markers Dspp and Dmp1. Ex vivo and in vitro studies further revealed dentin matrix hypoplasia, tooth root shortening and downregulation of Wnt signaling in Slc26a2-deficient cells. These findings highlight the crucial role of SLC26A2-mediated sulfate metabolism in tooth development and offer insights into the mechanisms underlying dental abnormalities in patients with SLC26A2-related chondrodysplasias.
Associations between Leisure and Work Time Activity Behavior and 24-h Ambulatory Blood Pressure among Aging Workers
Authors: NORHA JOOA , SUORSA KRISTIN , HEINONEN OLLI J. , NIIRANEN TEEMU , KALLIOKOSKI KARI K. , HEINONEN ILKKA H. A. , STENHOLM SARI 
Published: November 2024

ABSTRACT

Purpose
The associations between work time, leisure-time, and non-workday physical activity (PA) and sedentary behavior (SED), and 24-h ambulatory blood pressure (BP) are not well known. Therefore, the aim of this study was to evaluate the associations between domain-specific activity behavior and 24-h BP.

Methods
A hundred fifty-six aging workers (mean age, 62.4 (SD 1.0) yr; body mass index, 26.2 (4.5) kg·m−2; 84% women; 75% nonmanual occupation) from the Finnish Retirement and Aging study were included. Standing, light and moderate-to-vigorous PA, and SED were measured using thigh-worn accelerometers and work time, leisure-time, and non-workdays were distinguished using a diary. Ambulatory 24-h BP was analyzed as mean daytime and nighttime systolic and diastolic BP, and the nocturnal BP dipping percentage was calculated. Associations were examined with linear regression analysis adjusting for age, sex, occupation, work time mode, job strain, body mass index, BP medication, and accelerometer wear time.

Results
Higher work time SED was associated with lower nighttime diastolic BP (B = −0.92; 95% confidence interval (CI), −1.83 to −0.01). In addition, higher work time standing was associated with higher daytime diastolic BP (B = 1.34; 95% CI, 0.03 to 2.65), and higher work time light PA was associated with less diastolic BP dipping (B = −3.57; 95% CI, −6.80 to −0.34). Moderate-to-vigorous PA in any domain was not associated with ambulatory BP.

Conclusions
Higher work time SED was associated with a more favorable diastolic BP, and higher work time PA was associated with more adverse diastolic BP among aging workers. In conclusion, work time, rather than leisure time or non-workday, activity behavior seems to be associated with 24-h ambulatory BP.
Temporal Fairness in Learning and Earning: Price Protection Guarantee and Phase Transitions
Authors: Feng Qing , Zhu Ruihao , Jasin Stefanus 
Published: November 2024

Temporal Fairness in Data-Driven Dynamic Pricing Temporal fairness has long been recognized as a major issue in data-driven dynamic pricing. To address this, price protection guarantee has been proposed to mitigate such concern. Under this widely adopted guarantee, a customer who purchases a product can receive a refund from the seller if the seller lowers the price during the price protection period (defined as a certain time window after the purchase). In this paper, we initiate the study of the impact of this guarantee to online learning for data-driven dynamic pricing with initially unknown customer demand. Our results provide a fundamental characterization on the statistical complexity of this problem. In particular, we reveal a surprising phase transition behavior of the optimal regret with respect to the length of the price protection period. Not only that, our findings also offer practical insights in real-world deployment of price protection guarantees in data-driven dynamic pricing. That is, there is no harm to setting a long price protection period under very mild and realistic conditions.
Stochastic Online Fisher Markets: Static Pricing Limits and Adaptive Enhancements
Authors: Jalota Devansh , Ye Yinyu 
Published: November 2024

Dynamic Pricing in Fisher Markets Using Revealed Preferences In many markets, agents arrive online where complete information on user attributes is unavailable because of uncertainty or privacy issues. However, deriving equilibrium prices in Fisher markets, a canonical resource allocation framework, relies on complete knowledge of user attributes and requires a static market where all users are present simultaneously. In “Stochastic Online Fisher Markets: Static Pricing Limits and Adaptive Enhancements,” D. Jalota and Y. Ye address these limitations of classical Fisher markets by studying their online variant where users with privately known utility and budget parameters, drawn i.i.d. from a distribution, arrive sequentially. In this novel market, the authors establish the limitations of static pricing and design dynamic posted-price algorithms with improved guarantees. Their main result is a posted-price algorithm that solely relies on revealed preference (RP) feedback, that is, observations of user consumption, achieving the best-known guarantees for first-order algorithms in the RP setting while providing a regret analysis of a fairness-promoting logarithmic objective, unlike typical nonnegative and bounded efficiency-promoting objectives in online learning.
Análise epidemiológica da sepse comunitária e hospitalar em uma unidade de urgência e emergência
Authors: Bezerra Nayara Kalila dos Santos , Dias Barbara Almeida Soares , Caldart Raquel Voges , Silva Paulo Sérgio da 
Published: November 2024

Objetivo: analisar as características epidemiológicas da sepse de origem comunitária e hospitalar em uma unidade de urgência e emergência. Método: estudo transversal, descritivo, de base documental, com abordagem quantitativa, aprovado pelo Comitê de Ética em Pesquisa. Analisados dados de 143 prontuários de pacientes internados entre janeiro de 2020 e dezembro de 2021, por meio de frequências absolutas, relativas, média e dispersão. Resultados: observou-se tempo de internação prolongado à sepse de origem hospitalar (≥7 dias). A infecção pulmonar se destacou como a principal origem da sepse comunitária (68,6%) e os procedimentos invasivos, como o acesso venoso periférico (62,2%), foram os mais utilizados. Conclusão: reforça-se a necessidade de intervenções eficazes e imediatas para reduzir a mortalidade relacionada a essa condição. A compreensão da origem da sepse pode ajudar a implementar medidas de controle de infecção em ambientes hospitalares, guiando decisões clínicas importantes, permitindo o monitoramento mais eficaz da resposta ao tratamento, garantindo a eficácia terapêutica.
Refractory lipoatrophy treated with autologous whole blood injection: A case report
Authors: Kim Wonnam , Park Jun Su , Kim En Hyung 
Published: November 2024

BACKGROUND
Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy, alopecia, hypopigmentation, and hyperpigmentation. Although cutaneous atrophy can spontaneously resolve, several treatment options have been suggested for this condition.
CASE SUMMARY
In this paper, we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood (AWB) injection, as the condition had been unresponsive to fractional laser therapy. A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area, which had appeared six months earlier. There had been only subtle improvement at the margins after fractional CO2 laser treatment; therefore, after obtaining informed consent from the patient, AWB treatment was initiated. One month after the first AWB injection, the size and depth of the lesion had noticeably improved, and a slight improvement was also observed in discoloration.
CONCLUSION
Close observation is the initial treatment of choice for steroid induced skin atrophy; however, for patients in need of immediate cosmetic improvement, AWB injection may be a safe and cost-effective alternative.
Exploring prevalent injuries among tennis players and optimal rehabilitation approaches: A systematic review protocol
Authors: Rodríguez-González Eva María , Amor-Salamanca María Soledad , Rosselló Domingo , de Lluc-Bauza María , Hermosilla-Perona Francisco , Martín-Castellanos Adrián , Herrera-Peco Ivan 
Published: November 2024

Introduction
Tennis is a globally popular sport known for its numerous health benefits. However, it also underscores the physical demands and potential injuries associated with high-performance play. This review emphasizes the role of kinetic chains in executing powerful movements and discusses common injuries, particularly in the upper limbs due to the sport’s overhead nature. It highlights the importance of effective rehabilitation methods for swift recovery and long-term performance enhancement in high-performance tennis players.

Aims
The review aims to investigate the relationship between age, sex, and injury prevalence among high-performance tennis players to inform injury prevention strategies.

Methodology
This review protocol will provide a description on effective rehabilitation methods to tennis players, aiding coaches, physiotherapists and physicians. Methodologically, this systematic review will develop following the PRISMA guidelines, focusing on articles published between 2011 and 2024, with eligibility criteria specified. Data collection involved screening titles and abstracts, removing duplicates, and assessing full texts for eligibility. Data extraction will include information on authors, publication year, evidence level, participant demographics, injuries, treatments, etc. The GRADE framework will be used for evidence quality assessment, and NIH criteria were applied for study quality assessment.

Trial registration
Prospero registration number: CRD42023453182.
Impact of early work start on mental health outcomes in older adults: A cross-sectional study from Ecuador
Authors: Domínguez Romina , Faytong-Haro Marco 
Published: November 2024

Objective
This study assesses the impact of the age at which individuals first begin working on the odds of developing mental health disorders among older adults in Ecuador.

Methods
Data from the 2009 Survey of Health, Well-being, and Aging (SABE) encompassing 3093 elderly participants from mainland Ecuador were analyzed. We employed binary logistic regression to explore the association between the age at which individuals started working and their subsequent mental health status.

Results
Participants who started working between ages 5–12 and 26–35 had lower odds of mental health disorders compared to those who began at ages 18–25, while those who started working between ages 13–17 and 36–80 exhibited higher odds compared to the same baseline group. These associations are net of various demographic and health-related factors.

Conclusion
The results indicate mixed associations between the age at which individuals started working and their mental health outcomes in older age. While some age groups demonstrate lower odds of mental health disorders, others do not, suggesting a complex relationship that warrants further investigation.

Implications
This research supports the development of healthcare policies aimed at providing mental health education and services tailored to populations affected by early labor, to mitigate the enduring impacts of child labor on mental health in older age.