bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a bedside instrument to predict carbapenem resistance among gram-negative pathogens in complicated urinary tract infections
Authors: Zilberberg Marya D. , Nathanson Brian H. , Sulham Kate , Fan Weihong , Shorr Andrew F. 
Published: July 2018

AbstractWe developed a bedside instrument to predict carbapenem resistance in complicated urinary tract infections. A model assigning weighted points for admission from an extended care facility (1), history of weight loss (1), early mechanical ventilation (1), age <50 years (2), male gender (3), catheter-associated urinary tract infection (4), prior antibiotics treatment (4), and prior carbapenem-resistant infection (8) exhibited good discrimination (C statistic, 0.721).
Virgin olive oil and its phenol fraction modulate monocyte/macrophage functionality: a potential therapeutic strategy in the treatment of systemic lupus erythematosus
Authors: Aparicio-Soto Marina , Montserrat-de la Paz Sergio , Sanchez-Hidalgo Marina , Cardeno Ana , Bermudez Beatriz , Muriana Francisco J. G. , Alarcon-de-la-Lastra Catalina 
Published: July 2018

AbstractMonocytes and macrophages are critical effectors and regulators of inflammation and innate immune response, which appear altered in different autoimmune diseases such as systemic lupus erythematosus (SLE). Recent studies suggested that virgin olive oil (VOO) and particularly its phenol compounds might possess preventive effects on different immune-inflammatory diseases, including SLE. Here, we evaluated the effects of VOO (and sunflower oil) on lipopolysaccharide (LPS)-activated peritoneal macrophages from a model of pristane-induced SLE in BALB/c mice, as well as those of the phenol fraction (PF) from VOO on the immune-inflammatory activity and plasticity in monocytes and monocyte-derived macrophages from healthy volunteers. The release of nitrite and inflammatory cytokines was lower in LPS-treated peritoneal macrophages from pristane-SLE mice fed the VOO diet when compared with the sunflower oil diet. PF from VOO similarly decreased the secretion of nitrite and inflammatory cytokines and expression of inducible nitric oxide, PPARγand Toll-like receptor 4 in LPS-treated human monocytes. PF from VOO also prevented the deregulation of human monocyte subset distribution by LPS and blocked the genetic signature of M1 macrophages while favouring the phenotype of M2 macrophages upon canonical polarisation of naïve human macrophages. For the first time, our study provides several lines ofin vivoandin vitroevidence that VOO and PF from VOO target and counteract inflammatory pathways in the monocyte–macrophage lineage of mice with pristane-induced SLE and of healthy subjects, which is a meaningful foundation for further development and application in preclinical and clinical use of PF from VOO in patients with SLE.
Small sets containing any pattern
Authors: MOLTER URSULA , YAVICOLI ALEXIA 
Published: July 2018

AbstractGiven any dimension function h, we construct a perfect set E ⊆ ${\mathbb{R}}$ of zero h-Hausdorff measure, that contains any finite polynomial pattern.This is achieved as a special case of a more general construction in which we have a family of functions $\mathcal{F}$ that satisfy certain conditions and we construct a perfect set E in ${\mathbb{R}}^N$, of h-Hausdorff measure zero, such that for any finite set {f1,. . .,fn} ⊆ $\mathcal{F}$, E satisfies that $\bigcap_{i=1}^n f^{-1}_i(E)\neq\emptyset$.We also obtain an analogous result for the images of functions. Additionally we prove some related results for countable (not necessarily finite) intersections, obtaining, instead of a perfect set, an $\mathcal{F}_{\sigma}$ set without isolated points.
Prosodic rhythm, cultural background, and interaction in adolescent urban vernaculars in Paris: case studies and comparisons
Authors: FAGYAL ZSUZSANNA , TORGERSEN EIVIND 
Published: July 2018

ABSTRACTThis article presents the results of a corpus study of prosodic rhythm in the urban vernaculars of 24 female and male adolescents featured in the MPF corpus (Gardner-Chloros et al., 2014). Using canonical rhythm metrics, among them the normalized Pairwise Variability Index (nPVI), we show that there is no clear effect of gender and only a small effect of cultural background on the variability of adjacent vocalic and consonantal duration intervals, typically correlated with more or less syllable-timed rhythm. However, female and male teens with multicultural background who clearly dominated their conversational exchanges with their peers and also used multiple phonetic features attributed to adolescent urban-vernaculars in French tended to show more variability in interval durations, pointing to more stress-timed rhythm. We discuss these findings in comparison with other urban contact varieties in Europe and North America. We speculate that rather than the leveling of phonological contrasts, as in London English, or societal pressures to conform to monolingual norms, as in French spoken in minority contexts in Ontario, Canada, rhythm-type differences in the present corpus are tied to speakers’ allophonic repertoires and best thought of as elements of interactional styles.
Strasbourg, another setting for sociolinguistic variation in contemporary French
Authors: MARCHESSOU AGNES 
Published: July 2018

ABSTRACTThis paper reports on language practices in the city of Strasbourg, in a multi-ethnic working class neighbourhood. This provides a comparative setting to identify whether linguistic features are spreading between French cities. Data were collected from young speakers (16 to 21) using an ethnographic approach over a year. First, this paper will briefly review the literature on language variation research in France. Second, a comparison of vernacular features will be carried out, focusing on lexical innovations, indirect questions following the verb savoir (Gardner-Chloros and Secova, this issue), quotative systems (Cheshire and Secova, this issue) and discourse markers. Finally, the ethnographic data collected as part of this research will be used to consider how multi-ethnic working class neighbourhoods in France are connected with each other, and how language may be travelling between settings.
Paris: a sociolinguistic comparative perspective
Authors: BRITAIN DAVID 
Published: July 2018

AbstractThis article assesses the sociolinguistic impact and importance of the other articles in this special issue on Paris, considering three main themes that are evoked. First, the contribution of the articles here to the development of work on language variation and change on Hexagonal French within the variationist paradigm. Second, I address what I see as the important contribution made to our understanding of the ‘city’ as a sociolinguistic site. Finally, I focus on ethnicity as a social construct in recent variationist work in cities and consider what the articles here, and in comparison with cities elsewhere, add to our understanding of the impact of immigration on local manifestations of language variability. In each case, I attempt to show how these articles foreground or even problematize these three issues, and provide a prospectus for further research that can address unresolved questions.
A Combined Tree Ring and Vegetation Model Assessment of European Forest Growth Sensitivity to Interannual Climate Variability
Authors: Klesse S. , Babst F. , Lienert S. , Spahni R. , Joos F. , Bouriaud O. , Carrer M. , Di Filippo A. , Poulter B. , Trotsiuk V. , Wilson R. , Frank D. C. 
Published: July 2018

AbstractThe response of forest growth to climate variability varies along environmental gradients. A growth increase and decrease with warming is usually observed in cold‐humid and warm‐dry regions, respectively. However, it remains poorly known where the sign of these temperature effects switches. Here we introduce a newly developed European tree ring network that has been specifically collected to reconstruct forest aboveground biomass increment (ABI). We quantify, how the long‐term (1910–2009) interannual variability of ABI depends on local mean May–August temperature and test, if a dynamic global vegetation model ensemble reflects the resulting patterns. We find that sites at 8 °C mean May–August temperature increase ABI on average by 5.7 ± 1.3%, whereas sites at 20 °C decrease ABI by 3.0 ± 1.8% m−2 year−1 Δ°C−1. A threshold temperature between beneficial and detrimental effects of warming and the associated increase in water demand on tree growth emerged at 15.9 ± 1.4 °C mean May–August temperature. Because interannual variability increases proportionally with mean growth rate—that is, the coefficient of variation stays constant—we were able to validate these findings with a much larger tree ring data set that had been established following classic dendrochronological sampling schemes. While the observed climate sensitivity pattern is well reflected in the dynamic global vegetation model ensemble, there is a large spread of threshold temperatures between the individual models. Also, individual models disagree strongly on the magnitude of climate impact at the coldest and warmest locations, suggesting where model improvement is most needed to more accurately predict forest growth and effectively guide silvicultural practices.
Comment on “Surface Air Relative Humidities Spuriously Exceeding 100% in CMIP5 Model Output and Their Impact on Future Projections” by K. Ruosteenoja et al. (2017)
Authors: Genthon Christophe , Forbes Richard , Vignon Etienne , Gettelman Andrew , Madeleine Jean‐Baptiste 
Published: July 2018

Key Points

Ruosteenoja et al.'s () claim that supersaturation in the surface atmosphere is unrealistic and necessarily spurious and incorrect
Supersaturations are a reality that an increasing number of atmospheric models can reproduce even in the surface atmosphere
Modelers should not artificially cap relative humidity at 100% when feeding climate model archives
Myelofibrosis Treatment Algorithm 2018
Authors: Tefferi Ayalew , Guglielmelli Paola , Pardanani Animesh , Vannucchi Alessandro M. 
Published: July 2018

AbstractTwo novel prognostic systems for primary myelofibrosis (PMF) were recently unveiled: GIPSS (genetically inspired prognostic scoring system) and MIPSS70 (mutation-enhanced international prognostic scoring system for transplant-age patients). GIPSS is based exclusively on genetic markers: mutations and karyotype. MIPSS70 includes mutations and clinical risk factors. In its most recent adaptation, the prognostic value of MIPSS70 has been bolstered by the inclusion of a three-tiered cytogenetic risk stratification and use of hemoglobin thresholds that are adjusted for sex and severity (MIPSS70+ version 2.0). GIPSS features four, MIPSS70 three, and MIPSS70+ version 2.0 five risk categories. MIPSS70 is most useful in the absence of cytogenetic information. MIPSS70+ version 2.0 is more comprehensive than MIPSS70 and is the preferred model in the presence of cytogenetic information. Both MIPSS70 and MIPSS70+ version 2.0 require an online score calculator (http://www.mipss70score.it). GIPPS offers a lower complexity prognostic tool that reliably identifies candidates for allogeneic stem cell transplant (GIPSS high-risk disease) or long-term observation with little or no therapeutic intervention (GIPSS low-risk disease). Ultimately, we favor a step-wise prognostication approach that starts with GIPSS but also considers MIPSS70+ version 2.0 for confirming the most appropriate treatment approach for the individual patient.
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
Authors: Jun Hyun Jung , Appleman Vicky A. , Wu Hua-Jun , Rose Christopher M. , Pineda Javier J. , Yeo Alan T. , Delcuze Bethany , Lee Charlotte , Gyuris Aron , Zhu Haihao , Woolfenden Steve , Bronisz Agnieszka , Nakano Ichiro , Chiocca Ennio A. , Bronson Roderick T. , Ligon Keith L. , Sarkaria Jann N. , Gygi Steve P. , Michor Franziska , Mitchison Timothy J. , Charest Al 
Published: July 2018

AbstractGlioblastoma multiforme (GBM) is an aggressive primary brain cancer that includes focal amplification of PDGFRα and for which there are no effective therapies. Herein, we report the development of a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of overexpressed PDGFRα, and the analysis of GBM signaling pathways using proteomics. We discover the tubulin-binding protein Stathmin1 (STMN1) as a PDGFRα phospho-regulated target, and that this mis-regulation confers sensitivity to vinblastine (VB) cytotoxicity. Treatment of PDGFRα-positive mouse and a patient-derived xenograft (PDX) GBMs with VB in mice prolongs survival and is dependent on STMN1. Our work reveals a previously unconsidered link between PDGFRα activity and STMN1, and highlight an STMN1-dependent cytotoxic effect of VB in GBM.
Calcium is an essential cofactor for metal efflux by the ferroportin transporter family
Authors: Deshpande Chandrika N. , Ruwe T. Alex , Shawki Ali , Xin Vicky , Vieth Kyle R. , Valore Erika V. , Qiao Bo , Ganz Tomas , Nemeth Elizabeta , Mackenzie Bryan , Jormakka Mika 
Published: July 2018

AbstractFerroportin (Fpn)—the only known cellular iron exporter—transports dietary and recycled iron into the blood plasma, and transfers iron across the placenta. Despite its central role in iron metabolism, our molecular understanding of Fpn-mediated iron efflux remains incomplete. Here, we report that Ca2+ is required for human Fpn transport activity. Whereas iron efflux is stimulated by extracellular Ca2+ in the physiological range, Ca2+ is not transported. We determine the crystal structure of a Ca2+-bound BbFpn, a prokaryotic orthologue, and find that Ca2+ is a cofactor that facilitates a conformational change critical to the transport cycle. We also identify a substrate pocket accommodating a divalent transition metal complexed with a chelator. These findings support a model of iron export by Fpn and suggest a link between plasma calcium and iron homeostasis.
Network enhancement as a general method to denoise weighted biological networks
Authors: Wang Bo , Pourshafeie Armin , Zitnik Marinka , Zhu Junjie , Bustamante Carlos D. , Batzoglou Serafim , Leskovec Jure 
Published: July 2018

AbstractNetworks are ubiquitous in biology where they encode connectivity patterns at all scales of organization, from molecular to the biome. However, biological networks are noisy due to the limitations of measurement technology and inherent natural variation, which can hamper discovery of network patterns and dynamics. We propose Network Enhancement (NE), a method for improving the signal-to-noise ratio of undirected, weighted networks. NE uses a doubly stochastic matrix operator that induces sparsity and provides a closed-form solution that increases spectral eigengap of the input network. As a result, NE removes weak edges, enhances real connections, and leads to better downstream performance. Experiments show that NE improves gene–function prediction by denoising tissue-specific interaction networks, alleviates interpretation of noisy Hi-C contact maps from the human genome, and boosts fine-grained identification accuracy of species. Our results indicate that NE is widely applicable for denoising biological networks.
Self-assembly directed one-step synthesis of [4]radialene on Cu(100) surfaces
Authors: Li Qing , Gao Jianzhi , Li Youyong , Fuentes-Cabrera Miguel , Liu Mengxi , Qiu Xiaohui , Lin Haiping , Chi Lifeng , Pan Minghu 
Published: July 2018

AbstractThe synthetic challenges of radialenes have precluded their practical applications. Here, we report a one-step synthetic protocol of [4]radialene on a copper surface. High-resolution scanning tunneling microscopy measurements reveal that such catalytic reaction proceeds readily with high selectivity at the temperature below 120 K. First-principles calculations show that the reaction pathway is characterized by firstly the cooperative inter-molecular hydrogen tautomerization and then the C–C bond formation. The feasibility of such cyclotetramerization reaction can be interpreted by the surface effect of Cu(100), which firstly plays an important role in directing the molecular assembly and then serves as an active catalyst in the hydrogen tautomerization and C–C coupling processes. This work presents not only a novel strategy to the scant number of synthetic methods to produce [4]radialenes via a novel [1 + 1 + 1 + 1] reaction pathway, but also a successful example of C–C bond coupling reactions guided by the surface-induced C–H/π assembly.
Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration
Authors: Hisamoto Naoki , Tsuge Anna , Pastuhov Strahil Iv. , Shimizu Tatsuhiro , Hanafusa Hiroshi , Matsumoto Kunihiro 
Published: July 2018

AbstractFollowing axon injury, a cascade of signaling events is triggered to initiate axon regeneration. However, the mechanisms regulating axon regeneration are not well understood at present. In Caenorhabditis elegans, axon regeneration utilizes many of the components involved in phagocytosis, including integrin and Rac GTPase. Here, we identify the transthyretin (TTR)-like protein TTR-11 as a component functioning in axon regeneration upstream of integrin. We show that TTR-11 binds to both the extracellular domain of integrin-α and phosphatidylserine (PS). Axon injury induces the accumulation of PS around the injured axons in a manner dependent on TTR-11, the ABC transporter CED-7, and the caspase CED-3. Furthermore, we demonstrate that CED-3 activates CED-7 during axon regeneration. Thus, TTR-11 functions to link the PS injury signal to activation of the integrin pathway, which then initiates axon regeneration.
Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia
Authors: Bansal V. , Mitjans M. , Burik C. A. P. , Linnér R. K. , Okbay A. , Rietveld C. A. , Begemann M. , Bonn S. , Ripke S. , de Vlaming R. , Nivard M. G. , Ehrenreich H. , Koellinger P. D. 
Published: July 2018

AbstractHigher educational attainment (EA) is negatively associated with schizophrenia (SZ). However, recent studies found a positive genetic correlation between EA and SZ. We investigate possible causes of this counterintuitive finding using genome-wide association study results for EA and SZ (N = 443,581) and a replication cohort (1169 controls; 1067 cases) with deeply phenotyped SZ patients. We find strong genetic dependence between EA and SZ that cannot be explained by chance, linkage disequilibrium, or assortative mating. Instead, several genes seem to have pleiotropic effects on EA and SZ, but without a clear pattern of sign concordance. Using EA as a proxy phenotype, we isolateFOXO6andSLITRK1as novel candidate genes for SZ. Our results reveal that current SZ diagnoses aggregate over at least two disease subtypes: one part resembles high intelligence and bipolar disorder (BIP), while the other part is a cognitive disorder that is independent of BIP.
Sleep-dependent reconsolidation after memory destabilization in starlings
Authors: Brawn Timothy P. , Nusbaum Howard C. , Margoliash Daniel 
Published: July 2018

AbstractReconsolidation theory describes memory formation as an ongoing process that cycles between labile and stable states. Though sleep is critical for the initial consolidation of a memory, there has been little evidence that sleep facilitates reconsolidation. We now demonstrate in two experiments that a sleep-consolidated memory can be destabilized if the memory is reactivated by retrieval. The destabilized memory, which can be impaired if an interference task is encountered after, but not before, the memory is reactivated, is then reconsolidated after sleep. In two additional experiments, we provide evidence suggesting that the learning of the interference task promotes the subsequent sleep-dependent enhancement of the original memory. These results provide novel insight into the complex mechanisms of memory processing, as well as critical evidence supporting the view that long-term memory formation involves a dynamic process of sleep-dependent consolidation, use-dependent destabilization, and sleep-dependent reconsolidation.
Social interactions impact on the dopaminergic system and drive individuality
Authors: Torquet N. , Marti F. , Campart C. , Tolu S. , Nguyen C. , Oberto V. , Benallaoua M. , Naudé J. , Didienne S. , Debray N. , Jezequel S. , Le Gouestre L. , Hannesse B. , Mariani J. , Mourot A. , Faure P. 
Published: July 2018

AbstractIndividuality is a striking feature of animal behavior. Individual animals differ in traits and preferences which shape their interactions and their prospects for survival. However, the mechanisms underlying behavioral individuation are poorly understood and are generally considered to be genetic-based. Here, we devised a large environment, Souris City, in which mice live continuously in large groups. We observed the emergence of individual differences in social behavior, activity levels, and cognitive traits, even though the animals had low genetic diversity (inbred C57BL/6J strain). We further show that the phenotypic divergence in individual behaviors was mirrored by developing differences in midbrain dopamine neuron firing properties. Strikingly, modifying the social environment resulted in a fast re-adaptation of both the animal’s traits and its dopamine firing pattern. Individuality can rapidly change upon social challenges, and does not just depend on the genetic status or the accumulation of small differences throughout development.
Potential-induced nanoclustering of metallic catalysts during electrochemical CO2 reduction
Authors: Huang Jianfeng , Hörmann Nicolas , Oveisi Emad , Loiudice Anna , De Gregorio Gian Luca , Andreussi Oliviero , Marzari Nicola , Buonsanti Raffaella 
Published: July 2018

AbstractIn catalysis science stability is as crucial as activity and selectivity. Understanding the degradation pathways occurring during operation and developing mitigation strategies will eventually improve catalyst design, thus facilitating the translation of basic science to technological applications. Herein, we reveal the unique and general degradation mechanism of metallic nanocatalysts during electrochemical CO2 reduction, exemplified by different sized copper nanocubes. We follow their morphological evolution during operation and correlate it with the electrocatalytic performance. In contrast with the most common coalescence and dissolution/precipitation mechanisms, we find a potential-driven nanoclustering to be the predominant degradation pathway. Grand-potential density functional theory calculations confirm the role of the negative potential applied to reduce CO2 as the main driving force for the clustering. This study offers a novel outlook on future investigations of stability and degradation reaction mechanisms of nanocatalysts in electrochemical CO2 reduction and, more generally, in electroreduction reactions.