bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute kidney injury after aneurysmal subarachnoid hemorrhage and its effect on patient outcome: an exploratory analysis
Authors: Eagles Matthew E. , Powell Maria F. , Ayling Oliver G. S. , Tso Michael K. , Macdonald R. Loch 
Published: July 2019

OBJECTIVEAcute kidney injury (AKI) is associated with death in critically ill patients, but this complication has not been well characterized after aneurysmal subarachnoid hemorrhage (aSAH). The purpose of this study was to determine the incidence of AKI after aSAH and to identify risk factors for renal dysfunction. Secondary objectives were to examine what effect AKI has on patient mortality and functional outcome at 12 weeks post-aSAH.METHODSThe authors performed a post hoc analysis of the Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1) trial data set (clinical trial registration no.: NCT00111085, https://clinicaltrials.gov). The primary outcome of interest was the development of AKI, which was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Secondary outcomes of interest were death and a modified Rankin Scale score greater than 2 at 12 weeks post-aSAH. Propensity score matching was used to assess for a significant treatment effect related to clazosentan administration and AKI. Univariate analysis, locally weighted scatterplot smoothing (LOWESS) curves, and stepwise logistic regression models were used to evaluate for associations between baseline or disease-related characteristics and study outcomes.RESULTSOne hundred fifty-six (38%) of the 413 patients enrolled in the CONSCIOUS-1 trial developed AKI during their ICU stay. A history of hypertension (p < 0.001) and the number of nephrotoxic medications administered (p = 0.029) were independent predictors of AKI on multivariate analysis. AKI was an independent predictor of death (p = 0.028) but not a poor functional outcome (p = 0.21) on multivariate testing. Unresolved renal dysfunction was the strongest independent predictor of death in this cohort (p < 0.001).CONCLUSIONSAKI is a common complication following aSAH. Patients with premorbid hypertension and those treated with nephrotoxic medications may be at greater risk for renal dysfunction. AKI appears to confer an increased probability of death after aSAH.
Impact of temperature decline from the previous day as a trigger of spontaneous subarachnoid hemorrhage: case-crossover study of prefectural stroke database
Authors: Fukuda Hitoshi , Ninomiya Hitoshi , Ueba Yusuke , Ohta Tsuyoshi , Kaneko Toshiaki , Kadota Tomohito , Hamada Fumihiro , Fukui Naoki , Nonaka Motonobu , Watari Yuya , Nishimoto Shota , Fukuda Maki , Hayashi Satoru , Izumidani Tomohiko , Nishimura Hiroyuki , Moriki Akihito , Lo Benjamin , Ueba Tetsuya 
Published: July 2019

OBJECTIVESeveral environmental factors have been reported to correlate with incidence of spontaneous subarachnoid hemorrhage (SAH). However, because of different patient selection and study designs among these studies, meteorological factors that trigger the incidence of SAH in a short hazard period remain unknown. Among meteorological factors, daily temperature changes may disrupt and violate homeostasis and predispose to cerebrovascular circulatory disturbances and strokes. The authors aimed to investigate whether a decline in the temperature from the highest of the previous day to the lowest of the event day (temperature decline from the previous day [TDP]) triggers SAH in the prefecture-wide stroke database.METHODSAll 28 participating institutions with primary or comprehensive stroke centers located throughout Kochi Prefecture, Japan, were included in the study. Data collected between January 2012 and December 2016 were analyzed, and 715 consecutive SAH patients with a defined date of onset were enrolled. Meteorological data in this period were obtained from the Kochi Local Meteorological Observatory. A case-crossover study was performed to investigate association of TDP and other environmental factors with onset of SAH.RESULTSThe increasing TDP in 1°C on the day of the SAH event was associated with an increased incidence of SAH (OR 1.041, 95% CI 1.007–1.077) after adjustment for other environmental factors. According to the stratified analysis, a significant association between TDP and SAH was observed in women, patients < 65 years old, and patients with weekday onset. Among these factors, increasing TDP had a great impact on SAH onset in patients < 65 years old (p = 0.028, Mann-Whitney U-test).CONCLUSIONSTDP, temperature decline from the highest of the previous day to the lowest of the day, was correlated with the incidence of spontaneous SAH, particularly in younger patients < 65 years old.
Retromastoid-transmuscular identification and harvest of the occipital artery during retrosigmoid craniotomy
Authors: Tayebi Meybodi Ali , Lawton Michael T. , Moreira Leandro Borba , Zhao Xiaochun , Lang Michael J. , Nakaji Peter , Preul Mark C. 
Published: July 2019

OBJECTIVEHarvesting the occipital artery (OA) is challenging. The subcutaneous OA is usually found near the superior nuchal line and followed proximally, requiring a large incision and risking damage to the superficially located OA. The authors assessed the anatomical feasibility and safety of exposing the OA through a retromastoid-transmuscular approach.METHODSUsing 10 cadaveric heads, 20 OAs were harvested though a 5-cm retroauricular incision placed 5 cm posterior to the external auditory meatus. The underlying muscle layers were sequentially cut and recorded before exposing the OA. Changes in the orientation of muscle fibers were used as a roadmap to expose the OA without damaging it.RESULTSThe suboccipital segment of the OA was exposed without damage after incising two consecutive layers of muscles and their investing fasciae. These muscles displayed different fiber directions: the superficially located sternocleidomastoid muscle with vertically oriented fibers, and the underlying splenius capitis with anteroposteriorly (and mediolaterally) oriented fibers. The OA could be harvested along the entire length of the skin incision in all specimens. If needed, the incision can be extended proximally and/or distally to follow the OA and harvest greater lengths.CONCLUSIONSThis transmuscular technique for identification of the OA is a reliable method and may facilitate exposure and protection of the OA during a retrosigmoid approach. This technique may obviate the need for larger incisions when planning a bypass to nearby arteries in the posterior circulation via a retrosigmoid craniotomy. Additionally, the small skin incision can be enlarged when a different craniotomy and/or bypass is planned or when a greater length of the OA is needed to be harvested.
Temporal disconnection between pain relief and trigeminal nerve microstructural changes after Gamma Knife radiosurgery for trigeminal neuralgia
Authors: Shih-Ping Hung Peter , Tohyama Sarasa , Zhang Jia Y. , Hodaie Mojgan 
Published: July 2019

OBJECTIVEGamma Knife radiosurgery (GKRS) is a noninvasive surgical treatment option for patients with medically refractive classic trigeminal neuralgia (TN). The long-term microstructural consequences of radiosurgery and their association with pain relief remain unclear. To better understand this topic, the authors used diffusion tensor imaging (DTI) to characterize the effects of GKRS on trigeminal nerve microstructure over multiple posttreatment time points.METHODSNinety-two sets of 3-T anatomical and diffusion-weighted MR images from 55 patients with TN treated by GKRS were divided within 6-, 12-, and 24-month posttreatment time points into responder and nonresponder subgroups (≥ 75% and < 75% reduction in posttreatment pain intensity, respectively). Within each subgroup, posttreatment pain intensity was then assessed against pretreatment levels and followed by DTI metric analyses, contrasting treated and contralateral control nerves to identify specific biomarkers of successful pain relief.RESULTSGKRS resulted in successful pain relief that was accompanied by asynchronous reductions in fractional anisotropy (FA), which maximized 24 months after treatment. While GKRS responders demonstrated significantly reduced FA within the radiosurgery target 12 and 24 months posttreatment (p < 0.05 and p < 0.01, respectively), nonresponders had statistically indistinguishable DTI metrics between nerve types at each time point.CONCLUSIONSUltimately, this study serves as the first step toward an improved understanding of the long-term microstructural effect of radiosurgery on TN. Given that FA reductions remained specific to responders and were absent in nonresponders up to 24 months posttreatment, FA changes have the potential of serving as temporally consistent biomarkers of optimal pain relief following radiosurgical treatment for classic TN.
A phase II randomized controlled trial of tiopronin for aneurysmal subarachnoid hemorrhage
Authors: Ironside Natasha , Christophe Brandon , Bruce Samuel , Carpenter Amanda M. , Robison Trae , Yoh Nina , Cremers Serge , Landry Donald , Frey Hans-Peter , Chen Ching-Jen , Hoh Brian L. , Kim Louis J. , Claassen Jan , Connolly Edward Sander 
Published: July 2019

OBJECTIVEDelayed cerebral ischemia (DCI) is a significant contributor to poor outcomes after aneurysmal subarachnoid hemorrhage (aSAH). The neurotoxin 3-aminopropanal (3-AP) is upregulated in cerebral ischemia. This phase II clinical trial evaluated the efficacy of tiopronin in reducing CSF 3-AP levels in patients with aSAH.METHODSIn this prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial, 60 patients were assigned to receive tiopronin or placebo in a 1:1 ratio. Treatment was commenced within 96 hours after aSAH onset, administered at a dose of 3 g daily, and continued until 14 days after aSAH or hospital discharge, whichever occurred earlier. The primary efficacy outcome was the CSF 3-AP level at 7 ± 1 days after aSAH.RESULTSOf the 60 enrolled patients, 29 (97%) and 27 (93%) in the tiopronin and placebo arms, respectively, received more than one dose of the study drug or placebo. At post-aSAH day 7 ± 1, CSF samples were available in 41% (n = 12/29) and 48% (n = 13/27) of patients in the tiopronin and placebo arms, respectively. No difference in CSF 3-AP levels at post-aSAH day 7 ± 1 was observed between the study arms (11 ± 12 nmol/mL vs 13 ± 18 nmol/mL; p = 0.766). Prespecified adverse events led to early treatment cessation for 4 patients in the tiopronin arm and 2 in the placebo arm.CONCLUSIONSThe power of this study was affected by missing data. Therefore, the authors could not establish or refute an effect of tiopronin on CSF 3-AP levels. Additional observational studies investigating the role of 3-AP as a biomarker for DCI may be warranted prior to its use as a molecular target in future clinical trials.Clinical trial registration no.: NCT01095731 (ClinicalTrials.gov)
EFEKTIFITAS METODE SIKAT GIGI VERTIKAL DAN HORIZONTAL TERHADAP PENURUNAN INDEKS PLAK PADA ANAK USIA 9-11 TAHUN DI MI DDI SEPPANGE DI DESA TUNGKE KECAMATAN BENGO KABUPATEN BONE
Authors: Munadirah Munadirah , Saleh Muhammad 
Published: July 2019

Latar belakang, Pembersihan gigi yang kurang baik dapat menyebabkan terjadinya akumulasi plak. Salah satu cara menghilangkan plak yaitu dengan menyikat gigi. Plak adalah lapisan tipis, tidak berwarna, mengandung kumpulan bakteri, melekat pada permukaan gigi dan selalu terbentuk di dalam mulut dan bila bercampur dengan gula yang ada dalam makanan akan membentuk asam. Metode, Penentuan Sampel dalam penelitian ini yaitu menggunakan sampel random sampling dengan mencari 40 siswa siswi MI DDI Seppange di Desa Tungke Kecamatan Bengo Kabupaten Bone kemudian membaginya menjadi 2 kelompok yaitu 20 siswa dengan metode menyikat gigi secara vertkal dan 20 siswa dengan metode menyikat gigi secra horizontal yang diberi penyuluhan tentang kesehatan gigi dan mulut
ECOLOGY AND SUSTAINABLE DEVELOPMENT IN LOCAL BUSINESS:SIMULATION OF LOW IMPACT DEVELOPMENT IN SURAKARTA REGENCY
Authors: Samudro Bhimo Rizky , Pratama Yogi Pasca 
Published: July 2019

This paper will describe the function of water resources to support business activities in Surakarta regency, Central Java province. Surakarta is a business city in Central Java province with small business enterprises and specific culture. This city has a famous river with the name is Bengawan Solo. Bengawan Solo is a River Flow Regional (RFR) to support business activities in Surakarta regency. Concious with the function, societies and local government in Surakarta must to manage the sustainability of River Flow Regional (RFR) Bengawan Solo. It is important to manage the sustainability of business activity in Surakarta regency.
According to the condition in Surakarta regency, this paper will explain how the simulation of Low Impact Development Model in Surakarta regency. Low Impact Development is a model that can manage and evaluate sustainability of water resources in River Flow Regional (RFR). Low Impact Development can analys goals, structures, and process water resources management. The system can also evaluate results and impacts of water resources management. From this study, we hope that Low Impact Development can manage water resources in River Flow Regional (RFR) Bengawan Solo.
Desain Power System Stabilizer Berbasis Fuzzy dan Particle Swarm Optimization
Authors: Tamaji Tamaji 
Published: July 2019

One important factor to produce qualified electricity is the stability of the system. An unstable system resulted in an undamped oscilation of system, and the stable system can damp the oscilation quickly. Therefore, it is necessary to apply a stability device to a power system and it is called a Power System Stabilizer (PSS). One of stability design is a feedback control design. Here, in this research, the state feedback control is designed for Single Machine Infinite Bus (SMIB) . The SMIB model is non-linear therefore the feedback control can’t be designed directly. Some researchers do linearize the system before design the feedback control. In this research, a nonlinear model of SMIB is build in a state space form. Subsequently, a fuzzification Takagi-Sugeno is applied. The state feedback controls are applied to design the control of SMIB fuzzy system, a state feedback gain is determined using method Routh Hurwitz. Determining the parameter of state feedback gain influence the performance of SMIB. Therefore, it is important to determine the suitable parameter such that the SMIB has the optimal performance. The Particle Swarm Optimization (PSO) is applied to optimize the performance of SMIB. In this research, it is compared to the performance of SMIB by applying between Routh Hurwitz, fuzzy Routh Hurwitz, PSO fuzzy Routh Hurwitz for state feedback control. The simulation result shows that Performance of SMIB using The PSO Fuzzy Routh Hurwitz state feedback can improve the performance of SMIB, but the performance of Efd become oscillate and this method influenced by the chosen parameter
Suksesi Kepemimpinan Nasional Secara Selektif Berjenjang: Solusi Permasalahan Sistem Pemilihan Umum di Indonesia
Authors: Fuadi Afnan 
Published: July 2019

A variety of weaknesses and problems arise in the current electoral system, including high-cost political participation as well as weak leadership regeneration system. This article presents a solution to the problem through a new mechanism of leadership succession from the lowest level (neighborhood association) to the highest level (president). A literature review method is used in this study with a focus on; 1) the selection of leader by returning the principle of deliberation and consensus as a feature of Pancasila democracy; 2) the regeneration of leaders through a tiered selective system; and 3) discussion of the process of implementing leadership succession from the lowest to the highest level. Through this new concept of leadership succession, expensive political cost becomes relatively cheap, minimizing the emergence of corrupt behavior, the elected leader has a clear track record and avoid social division and conflict.
The Cultivation of Indonesiaâ€™s Education Financing Policy in Disruption Era
Authors: Octavianus Steaven 
Published: July 2019

This study is aimed at analyzing the development of education financing policy in Indonesia with the necessity of Indonesiaâ€™s people.Â The policy regarding to education financing has long been formulated in Indonesia. Nevertheless how about with its necessity with Indonesian people, it will be analysed trough this research. This research is using text analisis and it only analyzes the policy and law regarding to education financing based on the necessity of Indonesian people. Based on this research it was found that the regulation keeps growing in disruption era but it does not specifically regulate the existing problems in society.
Dukungan Keluarga Berpengaruh Kualitas Hidup Pada Lansia dengan Diagnosa Diabetes Melitus
Authors: Ratnawati Diah , Wahyudi Chandra Tri , Zetira Geby 
Published: July 2019

Diabetes melitus merupakan penyakit kronis yang sangat membutuhkan perawatan medis dalam waktu lama dan berakibat terjadinya komplikasi yang dapat mempengaruhi tingkat kualitas hidup seseorang terutama lansia. Kualitas hidup lansia bergantung dari dukungan keluarga sebagai komponen utama dalam mengontrol penyakit diabetes mellitus agar lansia dapat menikmati kehidupan masa tua dengan bahagia dan membantu lansia dalam menjalankan aktivitas sehari-hari secara teratur. Penelitian merupakan penelitian kuantitatif dengan menggunakan desain Cross Sectional (potong lintang). Tujuan penelitian ini untuk melihat adanya hubungan dukungan keluarga dengan kualitas hidup lansia diabetes melitus di Kelurahan Citayam Bogor. Cara pengambilan sampel melalui teknik startified sampling dan mendapatkan jumlah sampel sebanyak 134 orang. Analisa data menggunakan uji Chi Square. Hasil penelitian menunjukkan dukungan keluarga yang positif sebanyak 71 responden (53%) sedangkan untuk kualitas hidup positif sebanyak 67 responden (50%). Hasil analisis data diperoleh hasil p value=0,000 dan OR= 4,210 (2,043-8,679). Ada hubungan yang signifikan antara dukungan keluarga dengan kualitas hidup lansia diabetes melitus di Kelurahan Citayam Bogor. Lansia yang memiliki dukungan keluarga kurang baik mempunyai peluang 4,21 kali untuk kualitas hidup baik.
KONFLIK PENGUASAAN TANAH PERKEBUNAN
Authors: SAUNI HERAWAN 
Published: July 2019

Abstract There is a vivid imbalance in farm land domination. This emerge conflict in almost Indonesia territory. Structuring the ownership or control of land has been started since the Act Numebr 5 of 1960 as the reference in the structuring of the agricultural land holdings in Indonesia. However, what is hoped and be the justification reason the act seems has not shown as demanded. Based on Decree of Head of BPN RI Number 34 of 2007 on Technical Guidelines for Handling and Resolution of Land Issues, land conflicts arise regarding the issue of tenure, ownership, use or utilization of the plot of land. The enactment of Law No. 18 of 2004 on Plantations also open conflicts between farmers and plantation companies. Conflict occurs when the plantation is difference between one or more people or groups of people with plantation companies relating to land tenure estates. There are several factors that cause conflict, especially agricultural land tenure plantation land, namely: (1) inequality of agricultural land holdings; (2) there is a vagueness setting land rights; (3) wasteland physically; and (4) overlapping land ownership. Recalling the complexity of the conflict over land, land conflict resolution should be based not only on purely formal legal approach but also through other approaches such as economic, social and cultural.
MODEL KEBIJAKAN PEMERINTAH DESA DALAM PENGELOLAAN PASAR DESA DI KECAMATAN SUNGAI GELAM KABUPATEN MUARO JAMBI
Authors: Yarni Meri 
Published: July 2019

Desa sebagai entitas terkecil dari suatu pemerintahan daerah memiliki peran penting untuk mensukseskan pembangunan nasional. Oleh karena itu eksistensi desa tetap tidak dapat dilepaskan dari pengaturan pemerintah pusat dan diakomodir keberadaannya melalui Undang-Undang Nomor 6 Tahun 2014 tentang Desa. Penelitian ini bertujuan mengetahui dan menganalisis model kebijakan pemerintah desa dalam pelaksanaan peranan Kepala Desa dalam pengelolaan pasar desa Kecamatan Sungai Gelam Kabupaten Muaro Jambi dan menganalisis kendala-kendala yang dihadapi oleh Kepala Desa dalam pengelolaan pasar desa Sedangkan kegunaan penelitian ini dapat sebagai acuan dan masukan bagi pihak yang berkompeten khususnya dalam pelaksanaan tugas dari kepala desa dalam pengelolaan pasar desa khususnya di Kecamatan Sungai Gelam Kabupaten Muaro Jambi. Metode penelitian yang digunakan adalah tipe penelitian yuridis empiris dengan pendekatan perundang-perundangan dan pendekatan konseptual. Dari hasil penelitian dapat disarankan bahwa hendaknya untuk mengoptimalkan pengelolaan pasar desa di Kecamatan Sungai Gelam Kabupaten Muaro Jambi, pemerintah desa diberi kewenangan untuk mengeluarkan suatu kebijakan dalam pengelolaan pasar desa dan adanya mekanisme dan sistem pengelolaan yang baku serta system pertanggungjawaban yang benar.
Implementasi Gerakan Literasi Sekolah dalam Pembelajaran di Kelas Tinggi
Authors: Azimah Riadul 
Published: July 2019

Literacy in learning is an activity that aims to maintaim students’ reading interest to reading and reading activities and improve literacy skills (reading and writing) students by using enrichment books and learning textbooks. With respect to to the importance of literacy in learning then the author conducts research on high class teachers SDN 164 Pekanbaru with purpose for describe the implementation of the school literacy movement in learning in high class SDN 164 Pekanbaru. The type of research used is descriptive research. The subjects in this study were IVC class teacher, one IVC class student, and principal of SDN 164 Pekanbaru. Data collection is done by structured observation, structured interview and documentation. Data analysis techniques used are by reducing data, displaying data and concluding data. This study concluded that literacy has not been implemented in high class learning SDN 164 Pekanbaru namely the lack of facilities and infrastructure for schooly literacy movement, small classroom, one class used by two study groups, limited time and not fully understood by literacy class teachers.
On the existence of ‘supercavity modes’ in sub-wavelength dielectric resonators and their relation to bound states in the continuum
Authors: Klimov V V 
Published: July 2019

Abstract
It is shown in this letter related to the paper by M V Rybin and M F Limonov [Physics–Uspekhi
62 (8) (2019)] that in dielectric sub-wavelength resonators of equal volume but different shape no eigen-modes exist that would be qualitatively different from those in dielectric spheres. In particular, there are no ‘supercavity modes’ in dielectric cylinders whose Q-factor would exceed that of similar modes in dielectric spheres of the same volume.
Dielectric magnonics: from gigahertz to terahertz
Authors: Nikitov S A , Safin A R , Kalyabin D V , Sadovnikov A V , Beginin E N , Logunov M V , Morozova M A , Odintsov S A , Osokin S A , Sharaevskaya A Yu , Sharaevsky Yu P , Kirilyuk A I 
Published: July 2019

Abstract

State-of-the-art studies of dielectric magnonics and magnon spintronics are reviewed. Theoretical and experimental approaches to exploring physical processes in and calculations of the parameters of magnonic micro- and nanostructures are described. We discuss the basic concepts of magnon spintronics, the underlying physical phenomena, and the prospects for applying magnon spintronics for data processing, transmission, and reception. Special attention is paid to the feasibility of boosting the operating frequencies of magnonic devices from the gigahertz to terahertz frequency range. We also discuss specific implementations of the component base of magnonics and ways to further develop it.