bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between physical fitness level and number and severity of injury and illness in youth elite athletes
Authors: Moseid Christine Holm , Myklebust Grethe , Slaastuen Marit Kyte , Bar‐Yaacov Jonathan Brun , Kristiansen Aase Helen , Fagerland Morten Wang , Bahr Roald 
Published: June 2019

Youth elite athletes often double their training and competition load after enrollment into specialized sport academy high school programs. The least fit athletes may be exposed to an excessive and too rapid increase in training load, with negative adaptations such as injury and illness as a consequence. In this study, our aim was to determine whether these least fit athletes were at greater risk of injury or illness during their first school year. Participants were 166 youth elite athletes (72% boys) from a variety of team, technical, and endurance sports newly enrolled into specialized sport academy high schools. The Oslo Sports Trauma Research Center Questionnaire on Health Problems was used to self‐report injuries and illnesses weekly for 26 weeks. Athletes completed the Ironman Jr physical fitness test battery at baseline, evaluating endurance, strength, agility, and speed properties. We ranked the athletes based on their combined test scores and identified the least fit quartile. The main outcome was the number and severity of health problems, comparing the least fit quartile of athletes to the rest of the cohort. Overall, the least fit quartile of athletes did not report more health problems (mean 3.7, 95% CI 3.0‐4.4) compared with the rest of the cohort (3.6, 3.2‐3.9). In conclusion, we demonstrated no association between low physical fitness level and number and severity of injury and illness in youth elite athletes after enrollment into a specialized sport academy high school program.
The Effect of the First Goal on Match Score in Football for the Home Field Advantage
Authors: Inan Tuğbay , Cetin Beyza , Gungorur Ozge 
Published: June 2019

The interest in sports in the world is increasing in parallel with the developments in communication technology, . As a result of this increase, the number of researches conducted on sports industry and sport management has also showed an increase. The field of sport that attracts the most attention worldwide is football. Data analysis and statistical research are also included in football researches in this field of sports that intertwines with different fields of science such as football management, finance and sports industry. In addition to the econometric measurement methods on the related researches, the variables affecting the results of the competition and the statistical analyzes that determine the impact strength of these variables are more abundant in the literature. As a result of the competitions, the variables affecting the results of a competition attract the attention of football players, technical team, fans, media organizations and sports managers. When it comes to this study, it was planned to statistically determine the effect of the first goal in the European football leagues on the results of the match. From 5 countries in Europe Spain, France, Germany, England and Italy in particular, data belonging to the matches of the teams in which they were the home team between 2014-2017 seasons was used. A total of 5478 matches were analyzed in which 1140 matches were from Spain, 918 from Germany, 1140 from France, 1140 from England and 1140 from Italy. The relationship between the first goal and the match result was determined by the chi-square independence test. SPSS 24.0 package program was used in the analysis. The first goal independent variable in the study was examined and it was found that there was a relationship between the first goal and the match results (p <0.05). As far as results of the research data are concerned, it was found that there was a relationship between the first goal scored and the match results of the 5 major European football leagues when the teams were the home teams during the three seasons. Accordingly, the importance of the first goal was demonstrated by this study.
Design and Analysis of a Novel Integrated Wind-Solar-OTEC Energy System for Producing Hydrogen, Electricity, and Fresh Water
Authors: Ishaq Haris , Siddiqui Osamah , Dincer Ibrahim 
Published: June 2019

Abstract
A new energy system for power, hydrogen and fresh water production is proposed. The environmentally benign ocean thermal energy conversion (OTEC), wind and solar energy resources are utilized. The hybrid thermochemical CuCl cycle is used for hydrogen production, and the reverse osmosis (RO) desalination system is incorporated for producing fresh water. The presently developed system is analyzed through thermodynamic energy and exergy approaches. The energetic efficiency of the integrated trigeneration system is determined to be 45.3%, and the exergetic efficiency is found to be 44.9%. In addition to this, the energy efficiency of the OTEC power generation cycle is 4.5% while the exergy efficiency is found to be 12.9%. Furthermore, the CuCl hydrogen production cycle is examined to have exergetic and energetic efficiencies of 36% and 35.2%, respectively. Also, numerous parametric studies are performed to analyze the system performance at different operating parameters.
Viscoelastic Snapping Metamaterials
Authors: Dykstra David M. J. , Busink Joris , Ennis Bernard , Coulais Corentin 
Published: June 2019

Abstract
Mechanical metamaterials are artificial composites with tunable advanced mechanical properties. Particularly, interesting types of mechanical metamaterials are flexible metamaterials, which harness internal rotations and instabilities to exhibit programable deformations. However, to date, such materials have mostly been considered using nearly purely elastic constituents such as neo-Hookean rubbers. Here, we experimentally explore the mechanical snap-through response of metamaterials that are made of constituents that exhibit large viscoelastic relaxation effects, encountered in the vast majority of rubbers, in particular, in 3D printed rubbers. We show that they exhibit a very strong sensitivity to the loading rate. In particular, the mechanical instability is strongly affected beyond a certain loading rate. We rationalize our findings with a compliant mechanism model augmented with viscoelastic interactions, which qualitatively captures well the reported behavior, suggesting that the sensitivity to the loading rate stems from the nonlinear and inhomogeneous deformation rate, provoked by internal rotations. Our findings bring a novel understanding of metamaterials in the dynamical regime and open up avenues for the use of metamaterials for dynamical shape-changing as well as vibration and impact damping applications.
Bedding-parallel stylolites as a tool to unravel maximum burial depth in sedimentary basins: Application to Middle Jurassic carbonate reservoirs in the Paris basin, France
Authors: Beaudoin N. , Gasparrini M. , David M.-E. , Lacombe O. , Koehn D. 
Published: June 2019

AbstractIn recent years stylolites, which are rough dissolution surfaces commonly found in carbonates, have been used for paleopiezometry estimates. The Stylolite Roughness Inversion Technique (SRIT) applied on sedimentary bedding-parallel stylolites (BPS) grants access to the maximum principal vertical stress experienced by the host carbonates and thus to their maximum burial paleo-depth. This study reports the results of SRIT applied to a BPS population hosted in carbonate platform reservoirs of the Paris basin sub-surface (France). Middle Jurassic carbonates from two well cores from the depocenter and margin of the basin, for which the burial and thermal history are known, based on a thermally calibrated 3-D basin model, were analyzed. By defining a consistency criterion and using two signal treatment methods, we propose a new approach to select which BPS can be reliably used to reconstruct the maximum vertical stress undergone by the host carbonates, which then can be converted into maximum burial depth. The study of a BPS population shows that there is a control operated by the host rock texture and the stylolite morphology on the burial depth recorded. Especially suture and sharp peak BPS are better suited to estimate the real maximum depth, whereas seismogram pinning BPS record preferentially intermediate depths. Median values of maximum depth derived from our data set (1300 and 1650 m for the margin and depocenter cores, respectively) are in line with maximum burial estimates provided by conventional basin modeling (1450 and 1800 m, respectively), thus showing that SRIT is a standalone robust depth gauge in sedimentary basins, provided sample selection and data treatment are carried out in a rigorous and thoughtful manner.
Association between family history of diabetes and clusters of adherence to healthy behaviors: cross-sectional results from the Health Examinees-Gem (HEXA-G) study
Authors: Choi Jaesung , Choi Ji-Yeob , Lee Sang-Ah , Lee Kyoung-Mu , Shin Aesun , Oh Juhwan , Park JooYong , Song Minkyo , Yang Jae Jeong , Lee Jong-koo , Kang Daehee 
Published: June 2019

ObjectivesThis study evaluated whether individuals with affected family member adhered to healthy behaviours.Design and settingThis was a cross-sectional study of participants selected from health examinees who underwent the national health check-up programme of Korea in 39 centres between 2004 and 2013.ParticipantsThe baseline data of 128 520 participants enrolled in the Health Examinees-Gem study were used for analysis.Main outcomes and measuresAssociations of family history of diabetes with adherence to regular exercise, healthy diet and body composition, and clusters of healthy behaviours were evaluated while adjusting for potential confounders selected by a directed acyclic graph.ResultsParticipants with a family history of diabetes were more likely to adhere to a regular exercise regimen (OR=1.12, 95% CI 1.06 to 1.18 for men and OR=1.10, 95% CI 1.07 to 1.14 for women) and healthy diet (OR=1.06, 95% CI 1.01 to 1.12 for men and OR=1.06, 95% CI 1.01 to 1.12 for women) but were less likely to have a normal body composition (OR=0.83, 95% CI 0.78 to 0.87 for men and OR=0.83, 95% CI 0.80 to 0.86 for women). These associations were strengthened when the affected family members were siblings, the number of affected members was increased or the age at diagnosis of the affected member was younger than 50 years. In men and women, having a normal body composition is important in determining the cluster of behaviours, and those with a family history of diabetes were less likely to adhere to the normal body composition cluster.ConclusionsThe group with high risk of diabetes showed healthy behaviors, but they did not have a normal body composition. Policies and campaigns targeting integrated health behaviors will be needed to reduce the burden of diseases and improve public health.
Comparison of autoregressive integrated moving average model and generalised regression neural network model for prediction of haemorrhagic fever with renal syndrome in China: a time-series study
Authors: Wang Ya-wen , Shen Zhong-zhou , Jiang Yu 
Published: June 2019

ObjectivesHaemorrhagic fever with renal syndrome (HFRS) is a serious threat to public health in China, accounting for almost 90% cases reported globally. Infectious disease prediction may help in disease prevention despite some uncontrollable influence factors. This study conducted a comparison between a hybrid model and two single models in forecasting the monthly incidence of HFRS in China.DesignTime-series study.SettingThe People’s Republic of China.MethodsAutoregressive integrated moving average (ARIMA) model, generalised regression neural network (GRNN) model and hybrid ARIMA-GRNN model were constructed by R V.3.4.3 software. The monthly reported incidence of HFRS from January 2011 to May 2018 were adopted to evaluate models’ performance. Root mean square error (RMSE), mean absolute error (MAE) and mean absolute percentage error (MAPE) were adopted to evaluate these models’ effectiveness. Spatial stratified heterogeneity of the time series was tested by month and another GRNN model was built with a new series.ResultsThe monthly incidence of HFRS in the past several years showed a slight downtrend and obvious seasonal variation. A total of four plausible ARIMA models were built and ARIMA(2,1,1) (2,1,1)12model was selected as the optimal model in HFRS fitting. The smooth factors of the basic GRNN model and the hybrid model were 0.027 and 0.043, respectively. The single ARIMA model was the best in fitting part (MAPE=9.1154, MAE=89.0302, RMSE=138.8356) while the hybrid model was the best in prediction (MAPE=17.8335, MAE=152.3013, RMSE=196.4682). GRNN model was revised by building model with new series and the forecasting performance of revised model (MAPE=17.6095, MAE=163.8000, RMSE=169.4751) was better than original GRNN model (MAPE=19.2029, MAE=177.0356, RMSE=202.1684).ConclusionsThe hybrid ARIMA-GRNN model was better than single ARIMA and basic GRNN model in forecasting monthly incidence of HFRS in China. It could be considered as a decision-making tool in HFRS prevention and control.
Observational cohort study investigating cognitive outcomes, social networks and well-being in older adults: a study protocol
Authors: Siette Joyce , Georgiou Andrew , Westbrook Johanna 
Published: June 2019

IntroductionSocial networks play a role in slowing the development of dementia. However, there is a need for further investigation of the effects of improving social networks on health-related quality of life and cognitive performance. Targeted community aged care services are a central strategy for supporting older adults to initiate and maintain their social engagement with other individuals at all stages of later life. This protocol describes a prospective observational cohort study aimed at (1) characterising interpersonal relationships in older adults receiving community care services, (2) assessing the relationship social networks and health-related quality of life and cognition and (3) identifying the association between community care use, social networks and cognition. The findings will contribute to our understanding of how specific social network structures and social support services can maintain cognitive function in community-dwelling older adults.Methods and analysisThis is a prospective, observational cohort study of 201 older Australians residing in the community and receiving care services from one of three aged care organisations. Clients with a history of neurological injury will be excluded. Participants will undergo baseline measures of social networks, health-related quality of life and cognitive function, and a follow-up at 6 months. Service use and sociodemographic variables will also be collected. The primary outcome is cognitive function, and secondary outcomes include social networks and health-related quality of life. Multivariable linear regression will test the hypothesis that increased social networks are associated with an increase in cognitive function.Ethics and disseminationApproval of the study by Macquarie University Research Ethics Committee (reference number 5201831394062) has been obtained. This work will be disseminated by publication of peer-reviewed manuscripts, presentations in abstract form at scientific meetings and results will be made available to home and community-based care older adults and care staff of the involved organisations.Trial registration numberACTRN12618001723279; Pre-results.
Gene expression analysis of conjunctival epithelium of patients with Stevens-Johnson syndrome in the chronic stage
Authors: Ueta Mayumi , Sotozono Chie , Nishigaki Hiromi , Ohsako Suzuko , Yokoi Norihiko , Mizushima Katsura , Naito Yuji , Kinoshita Shigeru 
Published: June 2019

ObjectiveTo investigate the pathology underlying the ocular surface complications of patients with Stevens-Johnson syndrome (SJS) in the chronic stage.Methods and analysisUsing oligonucleotide microarrays, we performed comprehensive gene expression analysis of the conjunctival epithelium of patients with SJS in the chronic stage (n=3). The controls were patients with conjunctival chalasis (n=3). We confirmed the downregulation and upregulation of transcripts of interest by quantitative real-time PCR (RT-PCR) assay. The expression of ocular surface protein with significantly upregulated transcripts was assessed immunohistochemically.ResultsCompared with the controls, in the conjunctival epithelium of patients with SJS, 50 transcripts were downregulated by less than one-tenth (analysis of variance (ANOVA) p<0.05). Transcripts MUC7, PIGR, HEPACAM2, ADH1C and SMR3A were downregulated by less than one-fiftieth. 65 transcripts were upregulated more than 10- fold; the difference between patients with SJS and the controls was significant (ANOVA p<0.05). There were 14 transcripts that were upregulated more than 50-fold; they were SERPINB4, KRT1, KRTDAP, S100A7, SBSN, KLK6, SERPINB12, PNLIPRP3, CASP14, ODZ2, CA2, CRCT1, CWH43 and FLG. Quantitative RT-PCR of conjunctival epithelium samples from 11 patients with SJS and 26 controls showed that the gene expression of PIGR, HEPACAM2 and ADH1C was significantly downregulated while the gene expression of ODZ2 (teneurin-2) was significantly upregulated in patients with SJS. We document that teneurin-2 protein can be expressed in human conjunctival epithelium.ConclusionOur results suggest that the downregulation of PIGR, HEPACAM2 and ADH1C and upregulation of teneurin-2 expression contribute to the pathology of the ocular surface in patients with SJS in the chronic stage.
Constant expression of somatostatin receptor 2a in minute pulmonary meningothelial-like nodules
Authors: Tao LiLi , Chen Yaoli , Huang Qitao , Yong Juanjuan , Yan ShuMei , Huang Yuhua 
Published: June 2019

AimsAlthough ultrastructural studies showed that minute pulmonary meningothelial-like nodules (MPMNs) cells closely resembled meningothelial cells, their immunophenotype has not been well characterised, partly due to their rarity.MethodsSomatostatin receptor 2a (SSTR2a) and other markers of meningioma, including epithelial membrane antigen (EMA), progesterone receptor (PR) and S100, were analysed retrospectively in 19 MPMN cases from two institutions in China.ResultsThe median age of patients with MPMNs was 62.5 years (32–73 years), with a male-to-female ratio of 1:8.5. Most (15/19) patients with MPMNs had coexisting diseases, including adenocarcinomas (12 cases), bronchiectasis (1 case) and tuberculosis (2 cases). Just over half of the cases (10/19) were multifocal lesions (2–5 lesions). An additional 53 cases with 123 lesions from the literature were reviewed with reported immunophenotype information. In total, 162 lesions were included in the analysis. The size of nodules was 1–4 mm. All MPMN lesions (39/39) in the 19 cases showed strong and diffuse cytoplasmic expression of SSTR2a. The expression rate of SSTR2a was higher than that of conventional markers of meningioma, including EMA (86/138), PR (32/68) and S100 (1/125).ConclusionsOur observations expand the spectrum of recognised SSTR2a-positive lesions and once again demonstrated that MPMNs show immunohistochemical characteristics similar to meningothelial cells.
Dysregulated Tgfbr2/ERK-Smad4/SOX2 Signaling Promotes Lung Squamous Cell Carcinoma Formation
Authors: Wang Yanxiao , Tan Xiaohong , Tang Yuling , Zhang Chong , Xu Jiaqian , Zhou Jian , Cheng Xuan , Hou Ning , Liu Wenjia , Yang Guan , Teng Yan , Yang Xiao 
Published: June 2019

Abstract

Lung squamous cell carcinoma (SCC) is a common type of lung cancer. There is limited information on the genes and pathways that initiate lung SCC. Here, we report that loss of TGFβ type II receptor (Tgfbr2), frequently deleted in human lung cancer, led to predominant lung SCC development in KrasG12D mice with a short latency, high penetrance, and extensive metastases. Tgfbr2-loss–driven lung SCCs resembled the salient features of human lung SCC, including histopathology, inflammatory microenvironment, and biomarker expression. Surprisingly, loss of Smad4, a key mediator of Tgfbr2, failed to drive lung SCC; instead, low levels of phosphorylated ERK1/2, a Smad-independent downstream effector of Tgfbr2, were tightly associated with lung SCC in both mouse and human. Mechanistically, inhibition of phosphorylated ERK1/2 significantly upregulated the expression of SOX2, an oncogenic driver of lung SCC, and cooperated with SMAD4 repression to elevate SOX2. Inhibition of ERK1/2 in Smad4fl/fl;KrasG12D mice led to extensive lung SCC formation that resembled the SCC phenotype of Tgfbr2-deficient mice. Overall, we reveal a key role of ERK1/2 in suppressing SCC formation and demonstrate that dysregulated Tgfbr2/ERK-Smad4/SOX2 signaling drives lung SCC formation. We also present a mouse model of metastatic lung SCC that may be valuable for screening therapeutic targets.

Significance:
This study sheds new light on the mechanisms underlying lung SCC formation driven by mutated Kras.
Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia
Authors: Chan Wai-Kin , Horvath Thomas D. , Tan Lin , Link Todd , Harutyunyan Karine G. , Pontikos Michael A. , Anishkin Andriy , Du Di , Martin Leona A. , Yin Eric , Rempe Susan B. , Sukharev Sergei , Konopleva Marina , Weinstein John N. , Lorenzi Philip L. 
Published: June 2019

Abstract
We and others have reported that the anticancer activity of L-asparaginase (ASNase) against asparagine synthetase (ASNS)-positive cell types requires ASNase glutaminase activity, whereas anticancer activity against ASNS-negative cell types does not. Here, we attempted to disentangle the relationship between asparagine metabolism, glutamine metabolism, and downstream pathways that modulate cell viability by testing the hypothesis that ASNase anticancer activity is based on asparagine depletion rather than glutamine depletion per se. We tested ASNase wild-type (ASNaseWT) and its glutaminase-deficient Q59L mutant (ASNaseQ59L) and found that ASNase glutaminase activity contributed to durable anticancer activity against xenografts of the ASNS-negative Sup-B15 leukemia cell line in NOD/SCID gamma mice, whereas asparaginase activity alone yielded a mere growth delay. Our findings suggest that ASNase glutaminase activity is necessary for durable, single-agent anticancer activity in vivo, even against ASNS-negative cancer types.
Yoruba Language and Numerals’ Offline Interpreter Using Morphological and Template Matching
Authors: Oladayo Olakanmi Olufemi 
Published: June 2019

<p>Yoruba as a language has passed through generation reformations making some of the old documents in the archive to be unreadable by the present generation readers. Apart from this, some Yoruba writers usually mixed English numerals while writing due to brevity and conciseness of English numeral compare to Yoruba numerals which are combination of several characters. Re-typing such historical documents may be time consuming, therefore a need for an efficient Optical Character Reader (OCR) which will not only effectively recognize Yoruba texts but also converts all the English numerals in the document to Yoruba numerals.Several Optical Character Reader (OCR) systems had been developed to recognize characters or texts of some languages such as English, Arabic, Japanese, Chinese, and Korean, however, despite the significant contribution of Yoruba language to historical documentation and communication, it was observed that there is no particular OCR system for the language. In this paper correlation and template matching techniques were used to develop an OCR for the recognition of Yoruba based texts and convert English numerals in the document to Yoruba numerals. Experimental results show the relatively high accuracy of the developed OCR when it was tested on all size Yoruba alphabets and numerals.</p>