bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proliferative Effect of Tilapia Fish (Oreochromis niloticus) Lectin on BALB/c Mice Splenocytes
Authors: Cardoso da Silva Cynarha Daysy , Lagos de Melo Cristiane Moutinho , Matoso Maciel Carvalho Elba Verônica , Lino da Silva Mércia Andréa , Bezerra Rosiely Félix , Guerra dos Santos Athiê Jorge , Alves Pereira Valéria Rêgo , Breitenbach Barroso Coelho Luana Cassandra 
Published: September 2019

Background:
Lectins have been studied in recent years due to their immunomodulatory
activities.

Objective:
We purified a lectin named OniL from tilapia fish (Oreochromis niloticus) and here we
analyzed the cell proliferation and cytokine production in Balb/c mice splenocytes.

Methods:
Cells were stimulated in vitro in 24, 48, 72 hours and 6 days with different concentrations
of OniL and Con A. Evaluation of cell proliferation was performed through [3H]-thymidine
incorporation, cytokines were investigated using ELISA assay and cell viability assay was
performed by investigation of damage through signals of apoptosis and necrosis.

Results:
OniL did not promote significant cell death, induced high mitogenic activity in relation to
control and Con A and stimulated the cells to release high IL-2 and IL-6 cytokines.

Conclusion:
These findings suggest that, like Con A, OniL lectin can be used as a mitogenic agent
in immunostimulatory assays.
Performance of MALDI-TOF Mass Spectrometry for the Identification of the HACEK Group and Other Fastidious Gram-Negative Rods
Authors: Almuzara Marisa , V. Cárdenas Karen C. , Barberis Claudia , Ramirez Maria S. , Famiglietti Angela , Vay Carlos 
Published: September 2019

Objective:
The aim of this study was to determine the capacity of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) to identify 155 HACEK clinical isolates and other fastidious or infrequently isolated Gram-negative rods (e.g., Actinobacillus, Capnocytophaga, Pasteurella, Neisseria, Moraxella, Dysgonomonas, among others).

Methods:
All the isolates were identified by standard biochemical tests and MALDI-TOF MS. Two different extraction methods (direct transfer formic acid method on spot and ethanol formic acid extraction method) and different cut-offs for genus/specie level identification were used. MALDI-TOF MS identification was considered correct when the result obtained from the MS database agreed with the phenotypic identification result.
When both the methods gave discordant results, the 16S rDNA gene sequencing was considered as the gold standard identification method.

Results:
Employing the score cut-offs suggested by the manufacturer, 93.55% and 69.03% isolates were correctly identified at the genus and species level, respectively. On the contrary , employing lower cut-off scores for identification, 98.06% and 92.09% isolates were properly identified at the genus and species level respectively and no significant differences between the results obtained with two extraction methods were observed .

Conclusion:
The accurate identification of 14 genera showed the reliability of MALDI-TOF MS as an optional methodology to the routine identification methods currently used in laboratories.
Linking Implementation of Public Policy and Pilot Airmanship to Flight Safety in Indonesia: A Structural Equation Model
Authors: Supriyadi Adang Asep 
Published: September 2019

Background:
Although the flight accident rate in Indonesia has declined, several accidents still occur every year. In Indonesia, there are several major factors that can affect flight accidents, such as human error, policy aspect, limited facilities, and technological factors.

Aims:

The present study examines the relationship between the implementation of public policy and pilots’ airmanship and flight safety in Indonesia.

Methods:
Questionnaires with 171 questions about airmanship, flight safety, and public policy were distributed to 270 randomly selected Indonesian commercial pilots. A structural equation model was used to test the hypothesis model concerning the implementation of public policy, pilots’ airmanship, and flight safety.

Results:

The empirical results strongly support the hypothesis that there is a significant relationship between behavior, emotional intelligence, and self-efficacy and airmanship; a significant relationship between pilots’ airmanship and the implementation of public policies; and a significant relationship between the implementation of public policy and aviation safety.
The Relationship between Nausea and Vomiting with General and Psychological Health of Pregnant Women Referral to Clinics in Arak City, 2015
Authors: Vakilian Katayon , Aghdam Naficeh Seyyed Zadeh , Abadi Masoumeh Davod 
Published: September 2019

Objectives:
This study was conducted with the aim of investigating the relationship between pregnancy and nausea and vomiting with the general and mental health of pregnant women Referral to clinics in Arak in 2015.

Methods:
This cross-sectional study was conducted at one of the prenatal referral centers of the city of Arak in 2015. A questionnaire was completed for measuring the severity of nausea and vomiting for 310 eligible pregnant women eligible to enter the study. 240 out of 310 people had nausea and vomiting in pregnancy and 70 patients had no nausea and vomiting. Iranian version of SF-36 quality of life questionnaire was used to evaluate general and mental health indicators. The analysis was performed using SPSS version 18 software, descriptive statistics, percentage and mean, analytical T-test and analysis of variance.

Results:
The prevalence of nausea and vomiting was 77.5% among samples. The rate of mild nausea and vomiting index was moderate in 18.8% and it was observed to be severe in 59.2% and 22.1% of cases. All dimensions of the general health of pregnant women were significantly reduced (p <0.05) except for mental health, which was the same in all 2 groups.

Conclusion:
Considering that in this study, nausea and vomiting affected the general health and physical functioning of pregnant mothers, therefore it is suggested that health care providers have more emphasis on pharmaceutical and non-pharmaceutical techniques to reduce or improve these symptoms in a pregnant woman.
Cervical Cancer Related Knowledge, Attitude and Behaviour Among Women in Makasar District Primary Health Care Centre in 2018
Authors: Winarto Hariyono , Mitzy B. Skolastika , Widodo Aji Budi , Kurniawan Aan , Phallaphi Yudi Reza 
Published: September 2019

Introduction:
Cervical cancer is the 4th most prevalent cancer in women worldwide. Mortalities and morbidities are still increasing despite its preventability. The knowledge, attitude and behaviour of women in fighting cervical cancer are very important.

Objective:
This study aims to record knowledge, attitude, and behaviour of women in reproductive age regarding cervical cancer at Makasar District Primary Health Care Centre, East Jakarta in 2018

Material and Methods:
Descriptive cross-sectional study was conducted. Knowledge, attitude, and behaviour of cervical cancer were obtained using an assisted interview and recorded. The receipt of services towards cervical cancer prevention is referred to be favourable and unfavourable

Results:
Of the total 105 samples, the mean age was 30 years and mostly graduated from Junior High School (66.7%). More than half (59%) participants had poor knowledge about cervical cancer, but 89% of the participants had favourable attitude in receipt of services towards cervical cancer prevention. Despite the poor knowledge, 21.9% of the participants had been screened before.

Conclusion:
The knowledge and behaviour towards cervical cancer among women in Makasar Primary Health Care Centre are still inadequate but have favourable attitude.
The Effect of Physical Exercise Program in Patients with Type 2 Diabetes Mellitus in Ratchaburi Province, Thailand
Authors: Intana Jiriya , Khamthana Phenchamat , Siramaneerat Issara , Chaowilai Chalit 
Published: September 2019

Objective:
This study aimed at investigating the relationship between demographic and psychological characteristics with the status of physical activity of type 2 diabetic patients from Sub-District Health Promoting Hospital (SDHPH).

Methods:
Data were collected from 1,890 type 2 diabetic patients using self-registered questionnaires. The questionnaire included questions about demographic characteristics, and exercise, while medical records were examined for complications, treatments, and diabetes control indicators. Furthermore, descriptive statistics, chi-square tests and Fisher's exact test were performed. P-values <0.05 were considered statistically significant.

Results:
According to the result of Chi-square tests and Fisher's exact test, it was observed that education level and occupation were significantly influenced by physical activity level at significance levels of 0.05.

Conclusion:
This study shows that socio-demographic factors play an important role in exercise behavior, and these should be taken into account accordingly while designing fitness intervention.
Nonlinear Optical Properties of Materials Based on Graphene Oxide: A Review
Authors: Ebrahimi Mojtaba , Zakery Abdolnasser 
Published: September 2019

Background:
Nonlinear optical properties of Graphene and Graphene Oxide have been
widely used in industry and academia. Graphene oxide disperses easily in water and has easier interaction
with other materials because of the presence of oxygen groups. So, this feature of Graphene oxide
enables us to manipulate its nonlinear optical properties by combining it with other nanoparticles.

Objective:
We introduced recent advances in the nonlinear optical properties of materials based on
Graphene oxide.

Methods:
Nonlinear optical properties and optical limiting of Graphene oxide and/or its composites
with various nanoparticles, considering the wavelength and the incident pulse width, are investigated
in this review.

Conclusion:
At low intensities and in all pulse regimes, saturation absorption seems to be the dominant
mechanism of nonlinear absorption in Graphene oxide, while at higher intensities, the main
mechanism is the reverse saturation absorption. In the regime of very short pulses of picoseconds and
femtoseconds, the dominant mechanisms of two-photon and multiphoton absorption lead to reverse
saturation. In the nanosecond pulse regime, long laser pulses and short pulses with high pulse repetition
rates, excited-state absorption and nonlinear scattering due to thermal effects are causing the nonlinear
process.
Discovering Strong Communities in Social Networks Through Chromatic Correlation Clustering
Authors: Gothania Jaishri , Rathore Shashi K. 
Published: September 2019

Background:
Complex systems involved in biochemistry, neuroscience, physics, engineering
and social science are primarily studied and modeled through network structures. The connectivity
patterns within these interaction networks are discovered through clustering-like techniques.
Community discovery is a related problem to find patterns in networks.

Objective:
Existing algorithms either try to find few large communities in networks; or try to partition
network into small strongly connected communities; that too is time consuming and parameterdependant.

Methods/Results:
This paper proposes a chromatic correlation clustering method to discover small
strong communities in an interaction network in heuristic manner to have low time complexity and a
parameter free method. Comparison with other methods over synthetic data is done.

Conclusion:
Interaction networks are very large, sparse containing few small dense communities
that can be discovered only through method specifically designed for the purpose.
Numerical Studies of Blood Flow in Left Coronary Model
Authors: Pandey Rupali , Kumar Manoj , Srivastav Vivek Kumar 
Published: September 2019

Introduction:
Artery blockage is the most prevailing cause of Coronary Artery Disease
(CAD). The presence of blockage inside the artery breaks the continuity of blood supply to the other
part of the body and therefore causes for heart attack.

Objective:
Two different three-dimensional models namely; normal and 50% plaque are used for
the numerical studies. Five inlet velocities 0.10, 0.20, 0.50, 0.70 and 0.80 m/s are considered corresponding
to different blood flow conditions to study the effect of velocity on the human heart.

Methods:
Finite Volume Method (FVM) based Computational Fluid Dynamics (CFD) technique is
executed for the numerical simulation of blood flow. Hemodynamic factors are computed and compared
for the two geometrical models (Normal Vs. Blockage model).

Results:
Blood hemodynamic factor i.e. Area Average Wall Shear Stress (AAWSS) ranges from
4.1-33.6 Pa at the façade of the Left Anterior Descending (LAD) part of the Left Coronary Artery
(LCA) for the constricted artery.

Conclusion:
The predominantly low WSS index is analogous to the normal artery affirms the existence
of plaque. From the medical point of view, this can prove as an excellent factor for early diagnosis
of CAD. Therefore, a hindrance can be created in the increasing frequency of Myocardial Infarction
(MI). In future research we will adopt the unsteady flow with both rigid and elastic arterial
wall.
Design of a Consumer Mobile Health App for Heart Failure: Findings From the Nurse-Led Co-Design of Care4myHeart
Authors: Woods Leanna , Duff Jed , Roehrer Erin , Walker Kim , Cummings Elizabeth 
Published: September 2019

Background
Consumer health care technology shows potential to improve outcomes for community-dwelling persons with chronic conditions, yet health app quality varies considerably. In partnership with patients and family caregivers, hospital clinicians developed Care4myHeart, a mobile health (mHealth) app for heart failure (HF) self-management.

Objective
The aim of this paper was to report the outcomes of the nurse-led design process in the form of the features and functions of the developed app, Care4myHeart.

Methods
Seven patients, four family caregivers, and seven multidisciplinary hospital clinicians collaborated in a design thinking process of innovation. The co-design process, involving interviews, design workshops, and prototype feedback sessions, incorporated the lived experience of stakeholders and evidence-based literature in a design that would be relevant and developed with rigor.

Results
The home screen displays the priority HF self-management components with a reminder summary, general information on the condition, and a settings tab. The health management section allows patients to list health care team member’s contact details, schedule medical appointments, and store documents. The My Plan section contains nine important self-management components with a combination of information and advice pages, graphical representation of patient data, feedback, and more. The greatest strength of the co-design process to achieve the design outcomes was the involvement of local patients, family caregivers, and clinicians. Moreover, incorporating the literature, guidelines, and current practices into the design strengthened the relevance of the app to the health care context. However, the strength of context specificity is also a limitation to portability, and the final design is limited to the stakeholders involved in its development.

Conclusions
We recommend health app development teams strategically incorporate relevant stakeholders and literature to design mHealth solutions that are rigorously designed from a solid evidence base and are relevant to those who will use or recommend their use.
Understanding Implementation of a Digital Self-Monitoring Intervention for Relapse Prevention in Psychosis: Protocol for a Mixed Method Process Evaluation
Authors: Allan Stephanie , Mcleod Hamish , Bradstreet Simon , Beedie Sara , Moir Bethany , Gleeson John , Farhall John , Morton Emma , Gumley Andrew 
Published: September 2019

Background
Relapse is common in people who experience psychosis and is associated with many negative consequences, both societal and personal. People who relapse often exhibit changes (early warning signs [EWS]) in the period before relapse. Successful identification of EWS offers an opportunity for relapse prevention. However, several known barriers impede the use of EWS monitoring approaches. Early signs Monitoring to Prevent relapse in psychosis and prOmote Well-being, Engagement, and Recovery (EMPOWER) is a complex digital intervention that uses a mobile app to enhance the detection and management of self-reported changes in well-being. This is currently being tested in a pilot cluster randomized controlled trial. As digital interventions have not been widely used in relapse prevention, little is known about their implementation. Process evaluation studies run in parallel to clinical trials can provide valuable data on intervention feasibility.

Objective
This study aims to transparently describe the protocol for the process evaluation element of the EMPOWER trial. We will focus on the development of a process evaluation framework sensitive to the worldview of service users, mental health staff, and carers; the aims of the process evaluation itself; the proposed studies to address these aims; and a plan for integration of results from separate process evaluation studies into one overall report.

Methods
The overall process evaluation will utilize mixed methods across 6 substudies. Among them, 4 will use qualitative methodologies, 1 will use a mixed methods approach, and 1 will use quantitative methodologies.

Results
The results of all studies will be triangulated into an overall analysis and interpretation of key implementation lessons. EMPOWER was funded in 2016, recruitment finished in January 2018. Data analysis is currently under way and the first results are expected to be submitted for publication in December 2019.

Conclusions
The findings from this study will help identify implementation facilitators and barriers to EMPOWER. These insights will inform both upscaling decisions and optimization of a definitive trial.

Trial Registration
ISRCTN Registry ISRCTN99559262; http://www.isrctn.com/ISRCTN99559262

International Registered Report Identifier (IRRID)
DERR1-10.2196/15634
The Psychometric Properties of the Chinese eHealth Literacy Scale (C-eHEALS) in a Chinese Rural Population: Cross-Sectional Validation Study
Authors: Ma Zhihao , Wu Mei 
Published: September 2019

Background
The eHealth Literacy Scale (eHEALS) is the most widely used instrument in health studies to measure individual’s electronic health literacy. Nonetheless, despite the rapid development of the online medical industry and increased rural-urban disparities in China, very few studies have examined the characteristics of the eHEALS among Chinese rural people by using modern psychometric methods. This study evaluated the psychometric properties of eHEALS in a Chinese rural population by using both the classical test theory and item response theory methods.

Objective
This study aimed to develop a simplified Chinese version of the eHEALS (C-eHEALS) and evaluate its psychometric properties in a rural population.

Methods
A cross-sectional survey was conducted with 543 rural internet users in West China. The internal reliability was assessed using the Cronbach alpha coefficient. A one-factor structure of the C-eHEALS was obtained via principal component analysis, and fit indices for this structure were calculated using confirmatory factory analysis. Subsequently, the item discrimination, difficulty, and test information were estimated via the graded response model. Additionally, the criterion validity was confirmed through hypothesis testing.

Results
The C-eHEALS has good reliability. Both principal component analysis and confirmatory factory analysis showed that the scale has a one-factor structure. The graded response model revealed that all items of the C-eHEALS have response options that allow for differentiation between latent trait levels and the capture of substantial information regarding participants’ ability.

Conclusions
The findings indicate the high reliability and validity of the C-eHEALS and thus recommend its use for measuring eHealth literacy among the Chinese rural population.
Ser sociólogo/a: la habitual costumbre de la interrogación permanente
Authors: Valencia García Guadalupe 
Published: September 2019

<p>En el presente artículo se realiza una reflexión en torno al quehacer del sociólogo en la actualidad. Para ello se tomaron como ejes de análisis tres preguntas fundamentales: el por qué, el cómo y el para qué de la sociología, pues consideramos que la interrogación permanente sobre estas cuestiones es lo que permite la construcción del <em>ser</em> sociólogo. Plantear la cuestión de la interrogación permanente como condición de posibilidad de la disciplina permite contribuir al debate actual para dilucidar, desde una óptica amplia pero exigente, los problemas de su porvenir en el marco interpretativo de lo social y temporal.</p>
Pathogenetic Substantiation of the Therapeutic Impact on Microbiota in Irritable Bowel Syndrome
Authors: Shulpekova Yu. O. , Babaeva G. H. , Rusyaev V. Yu. 
Published: September 2019

Aim. This review aims to describe the nature of changes in the intestinal microbiota in irritable bowel syndrome (IBS) and provide a pathogenetic justification of the feasibility of a therapeutic impact on microbiota. General findings. An important aspect of the interaction of intestinal bacteria with the “host” cells is their contact with pattern recognition receptors of enterocytes, dendritic cell receptors, as well as a transcellular transport of antigens in the region of Peyer’s patches. The area of interaction of intestinal bacteria and the human body is not limited to the intestines. Intestinal bacteria demonstrate a significant humoral effect due to signalling molecules, some of which exhibit neurotransmitter properties. The study of the bacterial cross-feeding for various species, i.e. mutual use of nutrient substrates produced by bacteria of various species, is of a great interest. The development of a lowactivity inflammation in IBS can partly be explained by the increased interaction of flagellin with the corresponding receptor, as well as the influx of excess bacteria from the small intestine. The majority of studies on IBS have demonstrated the predominance of intestinal bacteria with pro-inflammatory potential (Enterobacteriaceae) and the lack of bacteria with a pronounced anti-inflammatory, antimicrobial and enzymatic action (Lactobacillus and Bifidobacterium), as well as increased mucus degradation. Similar changes are observed in inflammatory bowel diseases. Reduced microbial diversity increases susceptibility to intestinal infections and parasitoses, including those caused by protozoa conditionally pathogenic for adults, such as Blastocystis hominis hominis, Dientamoeba fragilis, Giardia lamblia. With the help of nutrition correction, the use of probiotics and functional foods containing certain probiotic strains, plant fibres (primarily psyllium) and, in some cases, nonabsorbable antibiotics, a positive effect can be achieved in a significant number of IBS patients. Recent works have shown that clinical improvement is accompanied by a change in the composition of the intestinal microbiota.Conclusion. For the pathogenetic treatment of irritable bowel syndrome, the use of non-drug treatment is justified, such as diet optimization and prescription of plant fibres and probiotic bacterial strains. The positive effect of such an approach is largely determined by modification of the intestinal microbiota composition. This opens up prospects for a further, more targeted impact on the intestinal microbiome.