bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors associated with the development of double‐inlet ventricle congenital heart disease
Authors: Paige Sharon L. , Yang Wei , Priest James R. , Botto Lorenzo D. , Shaw Gary M. , Collins Ronnie Thomas ,   the National Birth Defects Prevention Study
Published: March 2019

BackgroundCongenital heart disease (CHD) is the most common birth defect group and a significant contributor to neonatal and infant death. CHD with single ventricle anatomy, including hypoplastic left heart syndrome (HLHS), tricuspid atresia (TA), and various double‐inlet ventricle (DIV) malformations, is the most complex with the highest mortality. Prenatal risk factors associated with HLHS have been studied, but such data for DIV are lacking.MethodsWe analyzed DIV cases and nonmalformed controls in the National Birth Defects Prevention Study, a case‐control, multicenter population‐based study of birth defects. Random forest analysis identified potential predictor variables for DIV, which were included in multivariable models to estimate effect magnitude and directionality.ResultsRandom forest analysis identified pre‐pregnancy diabetes, history of maternal insulin use, maternal total lipid intake, paternal race, and intake of several foods and nutrients as potential predictors of DIV. Logistic regression confirmed pre‐pregnancy diabetes, maternal insulin use, and paternal race as risk factors for having a child with DIV. Additionally, higher maternal total fat intake was associated with a reduced risk.ConclusionsMaternal pre‐pregnancy diabetes and history of insulin use were associated with an increased risk of having an infant with DIV, while maternal lipid intake had an inverse association. These novel data provide multiple metabolic pathways for investigation to identify better the developmental etiologies of DIV and suggest that public health interventions targeting diabetes prevention and management in women of childbearing age could reduce CHD risk.
Hypercapnia downregulates hypoxia‐induced lysyl oxidase expression in pulmonary artery smooth muscle cells via inhibiting transforming growth factor β1 signalling
Authors: Xia Xiao‐dong , Peng Yan‐ping , Lei Dan , Chen Wei‐qian 
Published: March 2019

Hypoxic pulmonary arterial hypertension is characterized by elevated pulmonary vascular resistance and remodelling. Transforming growth factor‐β1 (TGF‐β1) is the master regulator in cellular response to hypoxia which can directly target lysyl oxidase (LOX). This study aimed to determine whether hypercapnia attenuates hypoxic pulmonary hypertension via regulating TGF‐β1 and LOX signalling. We found that exposure to hypercapnia ameliorated the increase in mean pulmonary artery pressure (mPAP) and ratio of right ventricle to left ventricle plus septum (RV/(LV + S)) induced by hypoxia but had no effect on mPAP and RV/(LV + S) in normoxia‐exposed control. In addition, exposure to hypoxia upregulated the mRNA and protein levels of LOX and TGF‐β1 in rat PASMCs both in vivo and in vitro, but these effects were abrogated by concurrent exposure to hypercapnia. The downregulation of LOX in rat PASMCs induced by hypercapnia was reversed by the administration with TGF‐β1, while TGF‐β1 knockdown repressed the upregulation of LOX in hypoxia‐exposed rat PASMCs. In conclusion, hypoxia upregulates LOX and TGF‐β1 expression in PASMCs and contributes to pulmonary hypertension. Hypercapnia downregulates hypoxia‐induced LOX expression and alleviates hypoxia‐associated pulmonary hypertension via inhibiting TGF‐β1 signalling.Significance of the StudyHypoxia‐induced upregulation of TGF‐β1, PDGF, and HIF‐1α plays a pivotal role in PAH, but molecular mechanism of how hypoxia regulates LOX expression is not clear. In the present study, we showed that mRNA and protein expression levels of LOX were substantially increased when TGF‐β1 was induced by hypoxia, and the effects were reversed by TGF‐β1 knockdown. Our study indicates that TGF‐β1 is implicated in the regulation of LOX.
Oxygen‐Deficient Ti0.9Nb0.1O2‐x as an Efficient Anodic Catalyst Support for PEM Water Electrolyzer
Authors: Lv Hong , Wang Sen , Hao Chuanpu , Zhou Wei , Li Jiakun , Xue Mingzhe , Zhang Cunman 
Published: March 2019

AbstractHerein, the low cost and efficient oxygen‐deficient Ti0.9Nb0.1O2‐x as support of IrO2 (noted as IrO2/TNO) anode catalyst for the PEM water electrolyzer is synthesized and then characterized using a series of techniques. Oxygen vacancies are introduced by hydrogenation treatment. The IrO2/TNO sample after hydrogenation (noted as IrO2/TNO−Hx, x corresponds to the hydrogenation temperature) exhibits enhanced electronic conductivity and increased surface active sites relative to that of the pristine IrO2/TNO sample. A single cell is assembled by IrO2/TNO−Hx as anode catalyst, commercial Pt/C as cathode catalytic and Nafion 117 membrane as electrolyte. At a low loading mass of IrO2, the IrO2/TNO−H750 sample shows the optimum oxygen evolution reaction (OER) activity (1.832 V at 1 A ⋅ cm−2), which is superior to that of unsupported IrO2 (1.858 eV at 1 A ⋅ cm−2), and remains stable for 100 h operating at a current density of 1 A cm−2. This work provides a rational design strategy for developing low cost and efficient anode catalysts support.
Ti−Pd Alloys as Heterogeneous Catalysts for the Hydrogen Autotransfer Reaction and Catalytic Improvement by Hydrogenation Effects
Authors: Takahashi Yuya , Kondo Ryota , Utsunomiya Masayoshi , Suzuki Takeyuki , Takeshita Hiroyuki T. , Obora Yasushi 
Published: March 2019

AbstractTi−Pd alloys were investigated as heterogeneous catalysts for hydrogen autotransfer reactions. This is the first reported study of alloys as catalysts for hydrogen‐borrowing reactions using alcohols. We improved the catalytic activities of alloys by increasing their specific surface areas via a hydrogenation−powdering process. The reactivities and selectivities of hydrogenated Ti−Pd alloys [Ti−Pd(Hy)] were higher than those of non‐hydrogenated alloy catalysts in N‐alkylation by hydrogen autotransfer using alcohols. A plausible catalytic cycle is proposed based on control studies and deuterium labelling experiments.
Progressive Freeze Concentration for Volume Reduction of Produced Water and Biodiesel Wastewater
Authors: Samsuri Shafirah , Rizan Nor Aman Nor , Hung Siew Hzien , Amran Nurul Aini , Sambudi Nonni Soraya 
Published: March 2019

AbstractOne way to conserve fresh water resources is by reusing water from wastewater. For instance, water can be removed from wastewater through formation of ice crystal layers by progressive freeze concentration (PFC). The application of PFC to remove water from produced water and biodiesel wastewater was assessed through the final concentration of concentrated wastewater and purity of melted ice crystals. No PFC study has been done on these applications. In order to evaluate the efficiency of PFC, the effective partition constant (K) and separation efficiency (SE) were calculated for the effect of stirring rate and coolant temperature. The results demonstrate that PFC is a more practical method for produced water, as compared to biodiesel wastewater which is based on the value of low K and high SE.
Engineering of Hierarchical and Three‐Dimensional Architectures Constructed by Titanium Nitride Nanowire Assemblies for Efficient Electrocatalysis
Authors: Liu Fangfang , Yang Xu , Dang Dai , Tian Xinlong 
Published: March 2019

AbstractElectrocatalysts that exhibit both, high performance and durability are essential for the promotion and commercialization of energy conversion devices. Transition metal nitrides (TMNs) hold great potential in many electrochemical catalytic processes, whereas the rational syntheses of highly open and three‐dimensional titanium nitride‐based nanostructures through a facile and efficient strategy is still a challenge. Herein, a scalable and effective method is proposed for the rational synthesis of mono‐ or bi‐metallic titanium nitride with three‐dimensional urchin‐like porous structures, which exhibit high electrochemical stability and structure durability. When being used as the support, the resultant electrocatalyst possesses much higher activity and durability in oxygen reduction reaction as well as methanol oxidation reaction. This work provides a general approach for the rational design of TMN‐based electrocatalysts or devices for application in energy conversion and storage technologies.
Photochemical, Metal‐Free Sigmatropic Rearrangement Reactions of Sulfur Ylides
Authors: Yang Zhen , Guo Yujing , Koenigs Rene M. 
Published: March 2019

AbstractSigmatropic rearrangement reactions constitute one of the most fundamental reactions of carbenes. While state‐of‐the‐art synthetic methods require the use of expensive precious metal catalysts, the application of visible light for the photolysis of α‐aryldiazoacetates is much less investigated and provides an operationally simple entry to carbenes under mild reaction conditions. Herein, we report on blue‐light induced sigmatropic rearrangement reactions of sulfur compounds with α‐aryldiazoacetates. This process, depending on the substitution pattern of the sulfide, opens up formal insertion reactions of carbenes into S−N, S−C, or C−H bonds.
Mechanistic Insights into Statistical Co‐Assembly of Metal Complexes
Authors: Coelho Joao Paulo , Matern Jonas , Albuquerque Rodrigo Q. , Fernández Gustavo 
Published: March 2019

AbstractStatistical copolymerization plays a key role in many biological and technological processes; however, mechanistic understanding of the formation of analogous supramolecular counterparts remains limited. Herein, we report detailed insights into the supramolecular co‐assembly of two π‐conjugated PdII and PtII complexes, which in isolation self‐assemble into flexible fibers and nanodisks, respectively. An efficient single‐step co‐assembly into only one type of nanostructure (fibers or nanodisks) takes place if any of the components is in excess. In contrast, equimolar mixtures lead to PdII‐rich fiber‐like co‐assemblies by a statistical co‐nucleation event along with a residual amount of self‐sorted nanodisks in a stepwise manner.
Inotuzumab ozogamicin versus standard of care in relapsed or refractory acute lymphoblastic leukemia: Final report and long‐term survival follow‐up from the randomized, phase 3 INO‐VATE study
Authors: Kantarjian Hagop M. , DeAngelo Daniel J. , Stelljes Matthias , Liedtke Michaela , Stock Wendy , Gökbuget Nicola , O’Brien Susan M. , Jabbour Elias , Wang Tao , Liang White Jane , Sleight Barbara , Vandendries Erik , Advani Anjali S. 
Published: March 2019

BackgroundInotuzumab ozogamicin (InO) is an antibody‐drug conjugate used for adults with relapsed/refractory B‐cell precursor (BCP) acute lymphoblastic leukemia (ALL). The INotuzumab Ozogamicin trial to inVestigAte Tolerability and Efficacy (INO‐VATE) previously reported improved outcomes with InO versus standard‐of‐care (SoC) chemotherapy. This article reports the final INO‐VATE results (≥2 years of follow‐up) and additional analyses of patient characteristics associated with improved outcomes.MethodsBetween August 27, 2012, and January 4, 2015, this multicenter, parallel, open‐label, phase 3 trial randomized 326 adults with relapsed/refractory ALL to InO (n = 164) or SoC (n = 162); 307 received 1 or more doses of the study drug (164 in the InO arm and 143 in the SoC arm).ResultsThe complete remission (CR)/complete remission with incomplete hematologic recovery (CRi) rate was higher with InO versus SoC (73.8% vs 30.9%; 1‐sided P < .0001), with consistent CR/CRi rates across patient subgroups. The median overall survival (OS) was 7.7 months with InO and 6.2 months with SoC, with 2‐year OS rates of 22.8% and 10.0%, respectively (overall hazard ratio, 0.75; 97.5% confidence interval [CI], 0.57‐0.99; 1‐sided P = .0105). The predictors of OS with InO were the best minimal residual disease status, baseline platelet count, duration of first remission, achievement of CR/CRi, and follow‐up hematopoietic stem cell transplantation (HSCT; all 2‐sided P values < .05). More InO arm patients proceeded directly to HSCT after achieving CR/CRi before any follow‐up induction therapy (39.6% [95% CI, 32.1%‐47.6%] vs 10.5% [6.2%‐16.3%]; 1‐sided P < .0001). The most frequent all‐grade and grade 3 or higher adverse events in both arms were hematologic. Veno‐occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS) was more frequent with InO (23 of 164 [14.0%] vs 3 of 143 [2.1%]).ConclusionsIn patients with relapsed/refractory BCP ALL in INO‐VATE, InO was associated with a greater likelihood of CR/CRi across key patient subgroups, and it served as a bridge to HSCT. Potential VOD/SOS risk factors must be considered when InO treatment decisions are being made.
Safety Profiles, Pharmacokinetics, and Changes in Bone Turnover Markers After Twice‐Weekly Subcutaneous Administration of Teriparatide in Healthy Japanese Postmenopausal Women: A Single‐Blind Randomized Study
Authors: Kumagai Yuji , Ose Atsushi , Tanaka Kosuke , Sugimoto Toshitsugu 
Published: March 2019

AbstractOnce‐weekly injection of 56.5‐μg teriparatide formulation is a potent therapeutic agent for osteoporosis treatment. However, this treatment has an issue of difficulty in continuing the treatment by its adverse side effects including nausea, vomiting, and headaches. To reduce these adverse side effects, we conducted a randomized, single‐blind, placebo‐controlled study to examine the pharmacokinetics, changes in bone turnover markers, and safety profiles of twice‐weekly 28.2‐μg teriparatide injections. Different dosing intervals of the twice‐weekly 28.2‐μg injections were also studied. A total of 100 healthy Japanese postmenopausal women were enrolled in this multiple‐dosing study. The systemic exposure of teriparatide acetate in the twice‐weekly 28.2‐μg injection was half that of the once‐weekly 56.5‐μg injection. Changes in bone turnover markers in the twice‐weekly 28.2‐μg injection were comparable to those in the once‐weekly 56.5‐μg injection. Incidences of adverse events including nausea, vomiting, and headaches were lower in the twice‐weekly 28.2‐μg injections than those in the once‐weekly 56.5‐μg injection. Findings were similar in the twice‐weekly 28.2‐μg injections regardless of the dosing interval. Thus, the new dosing regimen using twice‐weekly 28.2‐μg injections maintained comparable efficacy to the once‐weekly 56.5‐μg injections; however, it improved the safety profile and contributed to better continuity of care with teriparatide.
Enhancement of the Electrical Properties of DNA Molecular Wires through Incorporation of Perylenediimide DNA Base Surrogates
Authors: Lin Kuo‐Yao , Burke Anthony , King Nolan B. , Kahanda Dimithree , Mazaheripour Amir , Bartlett Andrew , Dibble David J. , McWilliams Marc A. , Taylor David W. , Jocson Jonah‐Micah , Minary‐Jolandan Majid , Gorodetsky Alon A. , Slinker Jason D. 
Published: March 2019

AbstractDNA has long been viewed as a promising material for nanoscale electronics, in part due to its well‐ordered arrangement of stacked, pi‐conjugated base pairs. Within this context, a number of studies have investigated how structural changes, backbone modifications, or artificial base substitutions affect the conductivity of DNA. Herein, we present a comparative study of the electrical properties of both well‐matched and perylene‐3,4,9,10‐tetracarboxylic diimide (PTCDI)‐containing DNA molecular wires that bridge nanoscale gold electrodes. By performing current‐voltage measurements for such devices, we find that the incorporation of PTCDI DNA base surrogates within our macromolecular constructs leads to an approximately 6‐fold enhancement in the observed current levels. Together, these findings suggest that PTCDI DNA base surrogates may enable the preparation of designer DNA‐based nanoscale electronic components.
Light‐Powered Self‐Sustainable Macroscopic Motion for the Active Locomotion of Materials
Authors: Kageyama Yoshiyuki 
Published: March 2019

AbstractThe creation of small robots comprised of tiny molecules is an intriguing research theme for chemists. Recently, there have been remarkable reports of photoresponsive molecules that exhibit mechanical function. Light‐driven multimolecular robots will likely soon be a commercial reality. However, most light‐actuated materials do not move self‐continuously; thus, microrobots made of these materials must have external controls. To create a drone‐type molecular robot, a self‐governing mechanism for mechanical movements must be installed. This Minireview summarizes recent reports of light‐driven materials that are capable of locomotion. By proposing a very simple model and numerical analysis to describe strategies for continuous motion, this paper shows that the coupling of nonlinear phenomena is the key underlying the self‐regulation of reactions in these materials, offering important design insights for researchers.
OMIP‐056: Evaluation of Human Conventional T Cells, Donor‐Unrestricted T Cells, and NK Cells Including Memory Phenotype by Intracellular Cytokine Staining
Authors: Dintwe One , Rohith Shamiska , Schwedhelm Katharine V. , McElrath M. Juliana , Andersen‐Nissen Erica , De Rosa Stephen C. 
Published: March 2019

AbstractA 26‐color staining panel was developed to profile human antigen‐specific T cells in an intracellular cytokine staining (ICS) assay using peptide pools to various antigens of interest. In addition to multiple functional markers, the panel includes differentiation/activation markers and markers to assess γδ, mucosal‐associated invariant T, and NK T cells as well as conventional NK cells. Panel optimization was performed using previously cryopreserved PBMC from healthy adults, and then, expression of key functional markers in the panel was cross‐validated against a validated ICS assay used in the HIV Vaccine Trials Network (HVTN). The panel is currently being used to evaluate the responses to tuberculosis and malaria vaccine candidates in volunteers from different geographic areas. © 2019 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
Generation of Nppa‐tagBFP reporter knock‐in mouse line for studying cardiac chamber specification
Authors: Zhang Zhentao , Zhang Qinkun , Lal Hind , Nam Young‐Jae 
Published: March 2019

SummaryNppa is a cardiac hormone which plays critical roles in regulating salt–water balance. Its expression is restricted to the atria of the healthy post‐natal heart. During heart development, spatio‐temporal expression of Nppa is dynamically changed within the heart and becomes restricted to the atria upon birth. In contrast to its atrial specific expression after birth, Nppa is re‐expressed in the adult ventricles in response to cardiac hypertrophy. To study cardiac chamber specification during development and pathological cardiac remodeling during heart disease, we generated a novel Nppa reporter mouse line by knocking‐in a tagBFP reporter cassette into 3′‐UTR of the Nppa gene without disrupting the endogenous gene. Our results demonstrated dynamic tagBFP expression in the developing heart, recapitulating the spatiotemporal expression pattern of endogenous Nppa. We also found that Nppa‐tagBFP is induced in the ventricle during pathological remodeling. Taken together, Nppa‐tagBFP reporter knock‐in mouse model described in this article will serve as a valuable tool to study cardiac chamber specification during development as well as pathological cardiac remodeling.
A coil layout of wireless power transfer systems based on multicoil arrangement for underwater vehicles
Authors: Sato Naoki , Kifune Hiroyasu , Komeda Shohei 
Published: March 2019

AbstractThis paper proposes an optimal coil layout of wireless power transfer (WPT) systems for underwater vehicles (UVs). The power supply station adopts a multicoil arrangement with a double layer, and the UV also uses two receiving coils. The proposed WPT system for UVs has a reasonable advantage, where it does not request to adjust the relative position of coils. This paper experimentally discusses an optimal coil layout based on measurement results of a coupling coefficient. As a result, the proposed coil arrangement with the geometry rule realizes a certain power transfer under any positions and directions of UVs.
Tuning the Electrochemical Property of the Ultrafine Metal‐oxide Nanoclusters by Iron Phthalocyanine as Efficient Catalysts for Energy Storage and Conversion
Authors: Cheng Yi , Wu Xing , Veder Jean‐Pierre , Thomsen Lars , Jiang San Ping , Wang Shuangyin 
Published: March 2019

Nanoclusters (NCs) have been demonstrated of outstanding performance in electrochemical energy storage and conversion technologies due to their strong quantum confinement effects and strong interaction with supports. Here, we developed a class of ultrafine metal‐oxide (MOx, M = Fe, Co and Ni) NCs incorporated with iron phthalocyanine (FePc), MOx/FePc‐G, supported on graphene as high‐performance catalysts for oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and carbon dioxide reduction (CO2RR). The high activities for ORR and OER are attributed to the electron donation and accepting ability of the highly redox active of FePc‐G that could tune the properties of MOx. The FeOx/FePc‐G exhibits an extremely positive half‐wave potential (E1/2) of 0.888 and 0.610 V for ORR in alkaline and neutral conditions, respectively, which is around 60 mV more positive than that of Pt/C. And NiOx/FePc‐G shows similar OER activity with the state‐of‐the‐art catalysts, Ir/C, and better performance than NiFeO NCs supported on graphene. Remarkably, the CoOx/FePc‐G and NiOx/FePc‐G show high activity and selectivity to reduce CO2 into CO with a low onset potential of −0.22 V (overpotential is 0.11 V).
Simultaneous Polymerization Enabled the Confinement of Size‐Adjustable TiO2 Nanocrystals in S‐Doped Carbons for High‐Rate Anode Materials
Authors: Gao Pengyuan , Lu Yun , Deng Shuyi , Cui Xun , Zhang Qing , Yang Yingkui 
Published: March 2019

Homogeneous confinement of metal oxide nanoparticles into the heteroatom‐doped carbon matrix is highly desirable but remains challenging to develop high‐performance anode materials. Herein, a facile simultaneous polymerization of 2‐thiophenemethanol (ThM) and titanium ethoxide (TTEO) is proposed to incorporate ultrafine anatase TiO2 nanocrystals into the continuous S‐doped carbon framework by carbonizing the as‐produced TiO2/poly(2‐thiophenemethanol) composites. This in situ crafting process spatially suppresses the growth of TiO2 by the polymerization of ThM, thus producing size‐adjustable TiO2 nanocrystals (5–50 nm) by tailoring the ratio of TTEO to ThM. It is found that smaller TiO2 nanocrystals are generated using the lower TTEO‐to‐ThM ratio. When used as lithium‐ion batteries (LIBs) anode, TiO2/S‐doped carbon (TSC) shows larger reversible capacity, superior rate capability, and better cycling stability compared to pure TiO2. A typical TSC with the smallest TiO2 nanocrystals (8 nm) shows the reversible capacity as high as 386 mAh g−1 at 50 mA g−1, and retains 55% of initial capacity at 500 mA g−1, and 96.8% capacity after 500 cycles at 1000 mA g−1. The excellent electrochemical performance is attributed to the shortened ion diffusion path of ultrafine TiO2 and the improved electronic conductivity, structural stability, and surface/interface nature by the S‐doped carbon matrix.