bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eye movements during text reading align with the rate of speech production
Authors: Gagl Benjamin , Gregorova Klara , Golch Julius , Hawelka Stefan , Sassenhagen Jona , Tavano Alessandro , Poeppel David , Fiebach Christian J. 
Published: August 2018

AbstractAcross languages, the speech signal is characterized by a predominant modulation of the amplitude spectrum between about 4.3-5.5Hz, reflecting the production and processing of linguistic information chunks (syllables, words) every ∼200ms. Interestingly, ∼200ms is also the typical duration of eye fixations during reading. Prompted by this observation, we demonstrate that German readers sample written text at ∼5Hz. A subsequent meta-analysis with 142 studies from 14 languages replicates this result, but also shows that sampling frequencies vary across languages between 3.9Hz and 5.2Hz, and that this variation systematically depends on the complexity of the writing systems (character-based vs. alphabetic systems, orthographic transparency). Finally, we demonstrate empirically a positive correlation between speech spectrum and eye-movement sampling in low-skilled readers. Based on this convergent evidence, we propose that during reading, our brain’s linguistic processing systems imprint a preferred processing rate, i.e., the rate of spoken language production and perception, onto the oculomotor system.
MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2
Authors: de Paz Alexia Martínez , Khajavi Leila , Martin Hélène , Claveria-Gimeno Rafael , Dieck Susanne tom , Cheema Manjinder S. , Sanchez-Mut Jose V. , Moksa Malgorzata M. , Carles Annaick , Brodie Nick I. , Sheikh Taimoor I. , Freeman Melissa E. , Petrotchenko Evgeniy V. , Borchers Christoph H. , Schuman Erin M. , Zytnicki Matthias , Velazquez-Campoy Adrian , Abian Olga , Hirst Martin , Esteller Manel , Vincent John B. , Malnou Cécile E. , Ausió Juan 
Published: August 2018

AbstractMeCP2 – a chromatin-binding protein associated with Rett syndrome – has two main isoforms, MeCP2-E1 and MeCP2-E2, with 96% amino acid identity differing in a few N-terminal amino acid residues. Previous studies have shown brain region-specific expression of these isoforms which, in addition to their different cellular localization and differential expression during brain development, suggest they may also have non-overlapping molecular mechanisms. However, differential functions of MeCP2-E1 and E2 remain largely unexplored. Here, we show that the N-terminal domains (NTD) of MeCP2-E1 and E2 modulate the ability of the methyl binding domain (MBD) to interact with DNA as well as influencing the turnover rates, binding dynamics, response to nuclear depolarization, and circadian oscillations of the two isoforms. Our proteomics data indicate that both isoforms exhibit unique interacting protein partners. Moreover, genome-wide analysis using ChIP-seq provide evidence for a shared as well as a specific regulation of different sets of genes. Our findings provide insight into the functional complexity of MeCP2 by dissecting differential aspects of its two isoforms.SignificanceWhether the two E1 and E2 isoforms of MeCP2 have different structural and/or functional implications has been highly controversial and is not well known. Here we show that the relatively short N-terminal sequence variation between the two isoforms impinges them with an important DNA binding difference. Moreover, MeCP2-E1 and E2 exhibit a different cellular dynamic behavior and have some distinctive interacting partners. In addition, while sharing genome occupancy they specifically bind to several distinctive genes.
Filter paper-based spin column for low throughput nucleic acid purification
Authors: Shi Rui , Lewis Ramsey S. , Panthee Dilip R. 
Published: August 2018

AbstractWe describe a method of recharging used spin column or assembling homemade spin column using filter paper as binding material for low throughput nucleic acid purification. We evaluated the efficiency of filter paper based spin columns in the purification of different type of nucleic acids. For instance, by following protocols of respective commercial kits, we found that filter paper to be a useful binding material for purification of many types of nucleic acids, including plant genomic DNA, plant total RNA, PCR product, and DNA from agarose gels. We also found that filter paper has a weak binding affinity to plasmid DNA in tested miniprep protocols. Also, we present the protocols of using filter paper recharged spin column or homemade spin column for low throughput purification of plant genomic DNA and plant total RNA with commercial kit buffer leftover and less expensive homemade buffer.
MicroRNAs are likely part of the molecular toolkit regulating adult reproductive diapause in the mosquito, Culex pipiens
Authors: Meuti Megan E. , Bautista Robin , Reynolds Julie A. 
Published: August 2018

AbstractFor many arthropods, including insects, diapause is the primary mechanism for survival during unfavorable seasons. Although the exogenous signals and endogenous hormones that induce and regulate diapause are well-characterized, we still lack a mechanistic understanding of how environmental information is translated into molecular regulators of the diapause pathway. However, short, non-coding microRNAs (miRNAs) are likely involved in generating both the arrested egg follicle development and fat hypertrophy in diapausing females of the Northern house mosquito, Culex pipiens. To determine whether miRNAs might respond to changes in day length and/or regulate diapause pathways, we measured the abundance of candidate miRNAs in diapausing and nondiapausing females of Cx. pipiens across the adult lifespan. Of the selected miRNAs nearly all were more abundant in nondiapausing females relative to diapausing females, but at different times. Specifically, miR-13b-3p, miR-14-3p, miR-277-3p, and miR-305-5p were upregulated in nondiapausing females early in adulthood, while miR-309-3p and miR-375-3p were upregulated later in adult life, and miR-8-3p and miR-275-3p were upregulated both early and late in adult life. Taken together, our data demonstrate that miRNA expression is dynamic, changing across adult lifespan. Further, differential miRNA expression between diapausing and nondiapausing females of Cx. pipiens suggests that this epigenetic mechanism is part of the molecular toolkit regulating diapause.
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter
Authors: Condon Mark D. , Platt Nicola J. , Zhang Yan-Feng , Roberts Bradley M. , Clements Michael A. , Vietti-Michelina Stefania , Tseu Min-Yee , Brimblecombe Katherine R. , Threlfell Sarah , Mann Ed O. , Cragg Stephanie J. 
Published: August 2018

AbstractMesostriatal DA neurons possess extensively branched axonal arbours. Whether action potentials are converted to DA output in striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. We addressed the roles for mechanisms governing release probability and axonal activity in determining short-term plasticity of DA release, using fast-scan cyclic voltammetry inex vivomouse striatum. Brief short-term facilitation (STF) and longer short-term depression (STD) were only weakly dependent on the level of initial release, i.e. were release-insensitive. Rather, short-term plasticity was strongly determined by mechanisms which governed axonal activation, including K+-gated excitability and the dopamine transporter (DAT), particularly in dorsal striatum. We identify the DAT as a master regulator of DA short-term plasticity, governing the balance between release-dependent and independent mechanisms that also show region-specific gating.Key FindingsShort-term plasticity in dopamine release is only weakly governed by initial releaseShort-term depression is strongly dependent on axonal excitability and activationThe dopamine transporter controls short-term plasticity and drives short-term depressionDopamine transporters govern the balance between release-dependent and -independent mechanisms
New topology of direct current claw-pole machines for stop-start application
Authors: Bazhar Sara , Ristagno Baptiste , Fontchastagner Julien , Takorabet Noureddine , Labbe Nicolas 
Published: August 2018

Purpose
This paper aims to propose a new topology of direct current (DC) machine using claw-pole stator to replace standard DC starter in micro-hybrid vehicles. The main interest of such a topology is the reduction of copper volume.

Design/methodology/approach
The design of the claw-pole machine is based on a multi-objective optimization of several topologies, based on a three-dimensional (3D) reluctance network modeling. The 3D finite element (FE) model is used to check the results of the optimization, and a prototype is manufactured and tested with satisfactory results.

Findings
The claw-pole topology with wave-shape windings allows to replace the current DC series classical starter because of to its copper volume saving.

Research limitations/implications
This model is only limited to the optimization of the claw-pole stator for a fixed geometry of the rotor.

Practical implications
The research outcome shows that claw-pole machine can replace the series-excited DC machines of starters and at the same time achieve the same performance at reduced copper volume.

Originality/value
The paper deals with a new DC machine topology to reduce the copper volume through the suppression of the classical stator end-windings. The use of Claw-Pole inductors ensures this copper reduction.
The appropriation cycle: novice and expert consumers
Authors: Stavraki Georgia , Plakoyiannaki Emmanuella , Clarke Jackie 
Published: August 2018

Purpose
Recognizing the value and limitations of current knowledge of the appropriation process in the consumption of aesthetic experiences, this research aims to generate a localized account for novice and expert consumers of the varying role of cultural capital in the appropriation cycles and interpretative responses of an aesthetic experience.

Design/methodology/approach
This research uses a single case study design of Miró’s blockbuster exhibition, and draws on multiple sources of evidence, notably 50 in-depth visitor interviews, observations and archival records.

Findings
An evidence-based framework of the appropriation process for novice and expert consumers of aesthetic experiences is offered. This framework highlights the significance of appropriation pace and personal versus communal interpretations – amongst other features – in distinguishing distinct versions of the appropriation process in accordance with the varied accumulation of consumer cultural capital.

Research limitations/implications
The transferability of the findings to other aesthetic or experience-based consumption contexts such as performing arts or sports is discussed, alongside the relevance of the proposed framework for researchers of aesthetic experiences.

Practical implications
The empirical investigation of the understudied connection between visitors’ cultural capital and their museum experiences provides insights into curatorial and marketing practices in terms of broadening, diversifying and engaging museum audiences.

Originality/value
This research provides new theoretical insights into the literature of appropriation process and consumption of art experiences by bringing together consumers’ cultural capital with the appropriation process and interpretive responses to an aesthetic experience.
Migrants’ health and well-being in the context of the Greek economic crisis: a narrative review
Authors: Psoinos Maria 
Published: August 2018

Purpose
Despite numerous studies on the separate health consequences of economic crises and post-migration difficulties, very little is known about the processes through which the intersection of economic crisis and post-migration adversity contribute to migrants’ health vulnerabilities. The purpose of this paper is to examine existing literature about how newly arrived and long-term migrants’ health and well-being are affected by the economic crisis in Greece.

Design/methodology/approach
The ongoing economic recession in Greece, combined with the recent migration crisis, provided an adequate context for investigating migrants’ health and well-being. A narrative literature review was performed on whether and how migrants’ health and well-being are affected by the economic and the migration crises in the particular case of Greece. Papers published between January 2010 and December 2017 were selected based on review of titles and abstracts, followed by a full text review.

Findings
The review identified a surprisingly limited number of relevant studies. Ultimately five studies were selected and their findings summarised. There was only one study attempting to unravel the specific processes through which the crisis and the post-migration problems impact cumulatively on migrants’ health and well-being and to suggest healthcare improvements. Further research on this topic is urgently needed.

Originality/value
This paper explores existing research looking at how migrants’ health and well-being are affected by the economic and the migration crises in Greece. The emerging dearth of research evidence on the above topic is also critically discussed from a socio-political point of view and recommendations are made related to healthcare practice and services set up for migrants’ health and care.
The profile of prisoners with tuberculosis in Japan
Authors: Kawatsu Lisa , Uchimura Kazuhiro , Kobayashi Makoto , Ishikawa Nobukatsu 
Published: August 2018

Purpose
Although globally, prisoners are considered one of the vulnerable groups to tuberculosis (TB), little is known about the situation of TB in prison setting in Japan. The purpose of this paper is to examine the characteristics of TB among prisoners in Japan.

Design/methodology/approach
Records of TB patients from one medical prison were analyzed in terms of general demographic characteristics, clinical manifestations, risk factors and delay in diagnosis and in initiating treatment, and compared with data from the national TB surveillance and other published data on health of inmates, where appropriate. Continuous variables were compared using student independent samples t-test. Proportions were compared using χ2 or Fisher exact test as appropriate. Kaplan–Meier survival analysis was conducted to determine the time from entry to prison institution to diagnosis of TB.

Findings
A total of 49 patients were analyzed. The mean age was 49.5 (±14.3) and 69.4 percent were males. Being unemployed and homeless prior to incarceration, and several co-morbidities were potential risk factors for TB (p<0.01). Analysis of diagnosis and treatment delay showed that 16.1 percent of smear positive patients took more than a week to be placed on treatment after being diagnosed of TB. Approximately 50 percent of the patients were diagnosed within four months of entering the prison institution.

Practical implications
Several potential risk factors identified suggest the need to strengthen screening for specific sub-groups within the prison population, such as those with poor socio-economic status and co-morbidities, as well as to consider the possible role of systematic screening for latent TB infection.

Originality/value
This study presents some important data to help understand the profile of TB patients in prisons in Japan, as well as showing that a detailed epidemiological analysis of existing records can provide useful insight.
Development of healthcare facility standards for Thai female inmates
Authors: Sawasdipanich Nantaga , Puektes Supa , Wannasuntad Supaporn , Sriyaporn Ankana , Chawmathagit Chulepon , Sintunava Jirapa , Paungsawad Gamjad 
Published: August 2018

Purpose
The purpose of this paper is to develop and evaluate the Standards of Healthcare Facility for Thai Female Inmates (SHF-TFI) through healthcare service improvement.

Design/methodology/approach
This research and quality improvement project was comprised of three phases. Surveying healthcare facilities and in-depth interviews with female inmates as well as prison nurses were employed in Phase I. Expert reviews and public hearing meetings were used for developing the SHF-TFI in Phase II. Satisfaction questionnaires, focus group interviews of the female inmates, and in-depth interviews with nurses and prison wardens were utilized to evaluate feasibility and effectiveness of SHF-TFI implementation in Phase III.

Findings
The SHF-TFI was elaborated in order to be more specific to the context of the correctional institutes and correspond with healthcare as to the needs of female inmates. It was divided into three main aspects: administrative standards, health service standards and outcome standards. After implementation, nurses reflected on the feasibility and benefits of the SHF-TFI on the organizations, inmates and nurses. The female inmates perceived remarkable improvement in the healthcare services including physical activity promotion and screening programs for non-communicable diseases, the physical environment and sufficiency of medical equipment. Moreover, the pregnant inmates and incarcerated mothers with children shared their views on better antenatal and child developmental care, as well as availability of baby supplies.

Originality/value
The findings support the feasibility and effectiveness of the SHF-TFI for quality care improvement and applicability of the Bangkok Rules in women’s correctional institutes.
Ethnic disparity in financial fragility in Malaysia
Authors: Abdullah Yusof Selamah 
Published: August 2018

Purpose
The purpose of this paper is to investigate the extent of financial fragility and its disparity across ethnic groups in Malaysia. Disparities related to income and wealth are major concerns as they breed conflict and social instability. The study also compares the level of financial fragility of Malaysians with their neighboring Asian counterparts.

Design/methodology/approach
This study uses the World Values Survey to construct two financial fragility measures. Descriptive analysis is used to compare the level of financial fragility of Malaysia with other Asian countries. Ordinary least squares and generalized ordered logit regressions are applied to determine the existence of ethnic disparity in financial fragility in Malaysia.

Findings
There exist ethnic differences in financial vulnerability in Malaysia where Malay and Indian are in a more financially fragile situation compared to Chinese. Other socio-economic factors and character trait also impact financial fragility. Compared to neighboring countries, the level of financial fragility in Malaysia is low. Nevertheless, over 40 percent of the Malaysians are just getting by in terms of their expenditure relative to income. They may be at risk to financial shocks without adequate savings or funds.

Social implications
Ethnic disparity in financial vulnerability added to the inequality in income and wealth can pose a serious threat to Malaysia which attempts to achieve long-lasting social harmony and sustainable development.

Originality/value
This is the first study that attempts to compare the level of individual financial fragility across Asian countries. It also makes use of a larger scale survey and a more representative sample to examine ethnic disparity in financial fragility in Malaysia. In addition, character trait is included in the analysis to provide a better understanding of human behavior in affecting financial outcomes.
Experiments on learning-based industrial bin-picking with iterative visual recognition
Authors: Harada Kensuke , Wan Weiwei , Tsuji Tokuo , Kikuchi Kohei , Nagata Kazuyuki , Onda Hiromu 
Published: August 2018

Purpose
This paper aims to automate the picking task needed in robotic assembly. Parts supplied to an assembly process are usually randomly staked in a box. If randomized bin-picking is introduced to a production process, we do not need any part-feeding machines or human workers to once arrange the objects to be picked by a robot. The authors introduce a learning-based method for randomized bin-picking.

Design/methodology/approach
The authors combine the learning-based approach on randomized bin-picking (Harada et al., 2014b) with iterative visual recognition (Harada et al., 2016a) and show additional experimental results. For learning, we use random forest explicitly considering the contact between a finger and a neighboring object. The iterative visual recognition method iteratively captures point cloud to obtain more complete point cloud of piled object by using 3D depth sensor attached at the wrist.

Findings
Compared with the authors’ previous research (Harada et al., 2014b) (Harada et al., 2016a), their new finding is as follows: by using random forest, the number of training data becomes extremely small. By adding penalty to occluded area, the learning-based method predicts the success after point cloud with less occluded area. We analyze the calculation time of the iterative visual recognition. We furthermore make clear the cases where a finger contacts neighboring objects.

Originality/value
The originality exists in the part where the authors combined the learning-based approach with the iterative visual recognition and supplied additional experimental results. After obtaining the complete point cloud of the piled object, prediction becomes effective.
A neural network based monitoring system for safety in shared work-space human-robot collaboration
Authors: Rajnathsing Hemant , Li Chenggang 
Published: August 2018

Purpose
Human–robot collaboration (HRC) is on the rise in a bid for improved flexibility in production cells. In the context of overlapping workspace between a human operator and an industrial robot, the major cause for concern rests on the safety of the former.

Design/methodology/approach
In light of recent advances and trends, this paper proposes to implement a monitoring system for the shared workspace HRC, which supplements the robot, to locate the human operator and to ensure that at all times a minimum safe distance is respected by the robot with respect to its human partner. The monitoring system consists of four neural networks, namely, an object detector, two neural networks responsible for assessing the detections and a simple, custom speech recognizer.

Findings
It was observed that with due consideration of the production cell, it is possible to create excellent data sets which result in promising performances of the neural networks. Each neural network can be further improved by using its mistakes as examples thrown back in the data set. Thus, the whole monitoring system can achieve a reliable performance.

Practical implications
Success of the proposed framework may lead to any industrial robot being suitable for use in HRC.

Originality/value
This paper proposes a system comprising neural networks in most part, and it looks at a digital representation of the workspace from a different angle. The exclusive use of neural networks is seen as an attempt to propose a system which can be relatively easily deployed in industrial settings as neural networks can be fine-tuned for adjustments.