bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence of pre-diabetes and diabetes and their associated factors in Northeast China: a cross-sectional study
Authors: Wang Rui , Zhang Peng , Li Zhijun , Lv Xin , Cai Hongfei , Gao Chunshi , Song Yuanyuan , Yu Yaqin , Li Bo , Cui Youbin 
Published: February 2019

AbstractThis study investigates the prevalence of pre-diabetes and diabetes and their associated risk factors among adults in Northeast China. A multistage stratified cluster sampling method was used to select adults from Jilin Province. Out of an initial recruitment of 23,050 individuals, 21,435 participants completed an interview and medical examination. The estimated prevalence of diabetes and pre-diabetes were 9.1% and 19.8%, respectively. The prevalence of hypertension, dyslipidemia, and obesity were the highest in participants with previously diagnosed diabetes. Participants who were previously diagnosed with diabetes were more likely to be aware of their hypertension and dyslipidemia status. Participants who were older, male, more educated, or who were widows or widowers were at greater risk for pre-diabetes. Similarly, those who were current drinkers or smokers, had higher BMI or waist circumference, had a family history of diabetes, or who reported they lived in urban areas or had low physical activity levels had increased pre-diabetes risk. The observed levels of diabetes and pre-diabetes in this study indicate that the medical authority needs to focus more attention in this area, and that health monitoring is essential to improving the health awareness of its residents.
Effects of dominance and prestige based social status on competition for attentional resources
Authors: Roberts Ashton , Palermo Romina , Visser Troy A. W. 
Published: February 2019

AbstractSocial status can be attained through either dominance (coercion and intimidation) or prestige (skill and respect). Individuals high in either of these status pathways are known to more readily attract gaze and covert spatial attention compared to their low-status counterparts. However it is not known if social status biases allocation of attentional resources to competing stimuli. To address this issue, we used an attentional blink paradigm to explore non-spatial attentional biases in response to face stimuli varying in dominance and prestige. Results from a series of studies consistently indicated that participants were biased towards allocating attention to low- relative to high- dominance faces. We also observed no effects of manipulating prestige on attentional bias. We attribute our results to the workings of comparatively early processing stages, separate from those mediating spatial attention shifts, which are tuned to physical features associated with low dominance. These findings challenge our current understanding of the impact of social status on attentional competition.
Graphene Oxide Induced Surface Modification for Functional Separators in Lithium Secondary Batteries
Authors: Kim Ju Young , Shin Dong Ok , Kim Kwang Man , Oh Jimin , Kim Jumi , Kang Seok Hun , Lee Myeong Ju , Lee Young-Gi 
Published: February 2019

AbstractFunctional separators, which have additional functions apart from the ionic conduction and electronic insulation of conventional separators, are highly in demand to realize the development of advanced lithium ion secondary batteries with high safety, high power density, and so on. Their fabrication is simply performed by additional deposition of diverse functional materials on conventional separators. However, the hydrophobic wetting nature of conventional separators induces the polarity-dependent wetting feature of slurries. Thus, an eco-friendly coating process of water-based slurry that is highly polar is hard to realize, which restricts the use of various functional materials dispersible in the polar solvent. This paper presents a surface modification of conventional separators that uses a solution-based coating of graphene oxide with a hydrophilic group. The simple method enables the large-scale tuning of surface wetting properties by altering the morphology and the surface polarity of conventional separators, without significant degradation of lithium ion transport. On the surface modified separator, superior wetting properties are realized and a functional separator, applicable to lithium metal secondary batteries, is demonstrated as an example. We believe that this simple surface modification using graphene oxide contributes to successful fabrication of various functional separators that are suitable for advanced secondary batteries.
Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation
Authors: Chandran Aneesh , Chee Xavier , Prole David L. , Rahman Taufiq 
Published: February 2019

AbstractInositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located ~100 Å away from the IP3-binding core (IBC). However, the precise mechanism of IP3 binding and correlated domain dynamics in the NT that are central to the IP3R activation, remains unknown. Our all-atom molecular dynamics (MD) simulations recapitulate the characteristic twist motion of the suppressor domain (SD) and reveal correlated ‘clam closure’ dynamics of IBC with IP3-binding, complementing existing suggestions on IP3R activation mechanism. Our study further reveals the existence of inter-domain dynamic correlation in the NT and establishes the SD to be critical for the conformational dynamics of IBC. Also, a tripartite interaction involving Glu283-Arg54-Asp444 at the SD – IBC interface seemed critical for IP3R activation. Intriguingly, during the sub-microsecond long simulation, we observed Arg269 undergoing an SD-dependent flipping of hydrogen bonding between the first and fifth phosphate groups of IP3. This seems to play a major role in determining the IP3 binding affinity of IBC in the presence/absence of the SD. Our study thus provides atomistic details of early molecular events occurring within the NT during and following IP3 binding that lead to channel gating.
BRAF V600E and SRC mutations as molecular markers for predicting prognosis and conversion surgery in Stage IV colorectal cancer
Authors: Shimada Yoshifumi , Muneoka Yusuke , Nagahashi Masayuki , Ichikawa Hiroshi , Tajima Yosuke , Hirose Yuki , Ando Takuya , Nakano Masato , Sakata Jun , Kameyama Hitoshi , Takii Yasumasa , Ling Yiwei , Okuda Shujiro , Takabe Kazuaki , Wakai Toshifumi 
Published: February 2019

AbstractComprehensive genomic sequencing (CGS) enables us to detect numerous genetic alterations in a single assay. We aimed to identify molecular markers for predicting prognosis and conversion surgery in Stage IV colorectal cancer (CRC) using CGS. One-hundred eleven patients with Stage IV CRC who underwent primary tumor resection were analyzed. We retrospectively investigated genetic alterations using CGS of a 415-gene panel. Clinicopathological variables and genetic alterations were analyzed to identify independent prognostic factors of overall survival (OS). Forty-five of 111 patients had R0 resection; of these, 11 patients underwent conversion surgery. Univariate and multivariate analyses identified histopathological grade 3, R0 resection, BRAF V600E mutation, and SRC mutation as independent prognostic factors for OS (P = 0.041, P = 0.013, P = 0.005, and P = 0.023, respectively). BRAF V600E and SRC mutations were mutually exclusive, and SRC mutation was significantly associated with left-sided tumor and liver metastasis compared to BRAF V600E mutation (P = 0.016 and P = 0.025, respectively). Eleven of the 74 initially unresectable patients underwent conversion surgery for R0 resection, yet none harbored BRAF V600E or SRC mutations. BRAF V600E and SRC mutations are important molecular markers which can predict prognosis and conversion surgery in Stage IV CRC.
The Limits of Earthquake Early Warning Accuracy and Best Alerting Strategy
Authors: Minson Sarah E. , Baltay Annemarie S. , Cochran Elizabeth S. , Hanks Thomas C. , Page Morgan T. , McBride Sara K. , Milner Kevin R. , Meier Men-Andrin 
Published: February 2019

AbstractWe explore how accurate earthquake early warning (EEW) can be, given our limited ability to forecast expected shaking even if the earthquake source is known. Because of the strong variability of ground motion metrics, such as peak ground acceleration (PGA) and peak ground velocity (PGV), we find that correct alerts (i.e., alerts that accurately estimate the ground motion will be above a predetermined damage threshold) are not expected to be the most common EEW outcome even when the earthquake magnitude and location are accurately determined. Infrequently, ground motion variability results in a user receiving a false alert because the ground motion turned out to be significantly smaller than the system expected. More commonly, users will experience missed alerts when the system does not issue an alert but the user experiences potentially damaging shaking. Despite these inherit limitations, EEW can significantly mitigate earthquake losses for false-alert-tolerant users who choose to receive alerts for expected ground motions much smaller than the level that could cause damage. Although this results in many false alerts (unnecessary alerts for earthquakes that do not produce damaging ground shaking), it minimizes the number of missed alerts and produces overall optimal performance.
Mutations in sigma 70 transcription factor improves expression of functional eukaryotic membrane proteins in Escherichia coli
Authors: Tomatis Pablo Emiliano , Schütz Marco , Umudumov Elina , Plückthun Andreas 
Published: February 2019

AbstractEukaryotic integral membrane proteins (IMPs) are difficult to study due to low functional expression levels. To investigate factors for efficient biogenesis of eukaryotic IMPs in the prokaryotic model organism Escherichia coli, important, e.g., for isotope-labeling for NMR, we selected for E. coli cells expressing high levels of functional G protein-coupled receptors (GPCRs) by FACS. Utilizing an E. coli strain library with all non-essential genes systematically deleted, we unexpectedly discovered upon whole-genome sequencing that the improved phenotype was not conferred by the deleted genes but by various subtle alterations in the “housekeeping” sigma 70 factor (RpoD). When analyzing effects of the rpoD mutations at the transcriptome level we found that toxic effects incurred on wild-type E. coli during receptor expression were diminished by two independent and synergistic effects: a slower but longer-lasting GPCR biosynthesis and an optimized transcriptional pattern, augmenting growth and expression at low temperature, setting the basis for further bacterial strain engineering.
Molecular origin of AuNPs-induced cytotoxicity and mechanistic study
Authors: Lee Euiyeon , Jeon Hyunjin , Lee Minhyeong , Ryu Jeahee , Kang Chungwon , Kim Soyoun , Jung Junghyun , Kwon Youngeun 
Published: February 2019

AbstractGold nanoparticles (AuNPs) with diverse physicochemical properties are reported to affect biological systems differently, but the relationship between the physicochemical properties of AuNPs and their biological effects is not clearly understood. Here, we aimed to elucidate the molecular origins of AuNP-induced cytotoxicity and their mechanisms, focusing on the surface charge and structural properties of modified AuNPs. We prepared a library of well-tailored AuNPs exhibiting various functional groups and surface charges. Through this work, we revealed that the direction or the magnitude of surface charge is not an exclusive factor that determines the cytotoxicity of AuNPs. We, instead, suggested that toxic AuNPs share a common structural characteristics of a hydrophobic moiety neighbouring the positive charge, which can induce lytic interaction with plasma membrane. Mechanistic study showed that the toxic AuNPs interfered with the formation of cytoskeletal structure to slow cell migration, inhibited DNA replication and caused DNA damage via oxidative stress to hinder cell proliferation. Gene expression analysis showed that the toxic AuNPs down-regulated genes associated with cell cycle processes. We discovered structural characteristics that define the cytotoxic AuNPs and suggested the mechanisms of their cytotoxicity. These findings will help us to understand and to predict the biological effects of modified AuNPs based on their physicochemical properties.
Ecological analysis of Kashin-Beck osteoarthropathy risk factors in Tibet’s Qamdo City, China
Authors: Zha Xinjie , Gao Xing 
Published: February 2019

AbstractWe studied Tibet’s Qamdo City, which currently hosts the most serious prevalence of Kashin-Beck osteoarthropathy (KB) in China. This study utilizes the geographical detector (GeoDetector) algorithm to measure the individual and interactive influences of risk factors on KB and to quantify the highest potential risk subzones of each principal factor. With a comprehensive consideration of 13 possible related factors, namely, the tectonic division, stratum, moisture index, gross domestic product, mean annual precipitation, soil type, groundwater type, elevation, mean annual temperature, vegetation type, geomorphic type, slope degree and slope aspect, our results indicate that the main exposure factors for KB in Qamdo City are geological factors (tectonic division and stratum), wetting factors (moisture index and mean annual precipitation), and an economic factor (gross domestic product). In contrast, other factors have little effect on the prevalence of KB in Qamdo City. All 13 factors either nonlinearly or bivariately enhance each other, and the interactions between these factors can increase the prevalence of KB. Consequently, it can be inferred that KB in Qamdo City is caused primarily by a set of multiple and interrelated disease risk factors.
First oxidation products from the reaction of hydroxyl radicals with isoprene for pristine environmental conditions
Authors: Berndt Torsten , Hyttinen Noora , Herrmann Hartmut , Hansel Armin 
Published: February 2019

AbstractIsoprene, C5H8, inserts about half of the non-methane carbon flux of biogenic origin into the atmosphere. Its degradation is primarily initiated by the reaction with hydroxyl radicals. Here we show experimentally the formation of reactive intermediates and corresponding closed-shell products from the reaction of hydroxyl radicals with isoprene for low nitric oxide and low hydroperoxy radical conditions. Detailed product analysis is achieved by mass spectrometric techniques. Quantum chemical calculations support the usefulness of applied ionization schemes. Observed peroxy radicals are the isomeric HO-C5H8O2 radicals and their isomerization products HO-C5H8(O2)O2, bearing most likely an additional hydroperoxy group, and in traces HO-C5H8(O2)2O2 with two hydroperoxy groups. Main closed-shell products from unimolecular peroxy radical reactions are hydroperoxy aldehydes, C5H8O3, and smaller yield products with the composition C5H8O4 and C4H8O5. Detected signals of C10H18O4, C10H18O6, and C5H10O2 stand for products arising from peroxy radical self- and cross-reactions.
Unveiling a cluster of protostellar disks around the massive protostar GGD 27 MM1
Authors: Busquet G. , Girart J. M. , Estalella R. , Fernández-López M. , Galván-Madrid R. , Anglada G. , Carrasco-González C. , Añez-López N. , Curiel S. , Osorio M. , Rodríguez L. F. , Torrelles J. M. 
Published: February 2019

Context. Most stars form in clusters and thus it is important to characterize the protostellar disk population in dense environments to assess whether the environment plays a role in the subsequent evolution. Specifically, it is critical to evaluate whether planet formation is altered with respect to more isolated stars formed in dark clouds.
Aims. We seek to investigate the properties of the protostellar disks in the GGD 27 cluster and compare these with those obtained from disks formed in nearby regions.
Methods. We used ALMA to observe the star-forming region GGD 27 at 1.14 mm with an unprecedented angular resolution, 40 mas (∼56 au), and sensitivity (∼0.002 M⊙).
Results. We detected a cluster of 25 continuum sources, most of which likely trace disks around Class 0/I protostars. Excluding the two most massive objects, disks masses are in the range 0.003–0.05 M⊙. The analysis of the cluster properties indicates that GGD 27 displays moderate subclustering. This result, combined with the dynamical timescale of the radio jet (∼104 years), suggests the youthfulness of the cluster. The lack of disk mass segregation signatures may support this as well. We found a clear paucity of disks with Rdisk >  100 au. The median value of the radius is 34 au; this value is smaller than the median of 92 au for Taurus but comparable to the value found in Ophiuchus and in the Orion Nebula Cluster. In GGD 27 there is no evidence of a distance-dependent disk mass distribution (i.e., disk mass depletion due to external photoevaporation), most likely due to the cluster youth.
There is a clear deficit of disks for distances <0.02 pc. Stars can only form larger and more massive disksfor distances >0.04 pc. This suggests that dynamical interactions far from the cluster center are weaker, although the small disks found could be the result of disk truncation. This work demonstrates the potential to characterize disks from low-mass young stellar objects in distant and massive (still deeply embedded) clustered environments.
Open clusters in APOGEE and GALAH
Authors: Carrera R. , Bragaglia A. , Cantat-Gaudin T. , Vallenari A. , Balaguer-Núñez L. , Bossini D. , Casamiquela L. , Jordi C. , Sordo R. , Soubiran C. 
Published: February 2019

Context. Open clusters are ideal laboratories to investigate a variety of astrophysical topics, from the properties of the Galactic disc to stellar-evolution models. Knowing their metallicity and possibly detailed chemical abundances is therefore important. However, the number of systems with chemical abundances determined from high-resolution spectroscopy remains small.
Aims. Our aim is to increase the number of open clusters with radial velocities and chemical abundances determined from high-resolution spectroscopy using publicly available catalogues of surveys in combination with Gaia data.
Methods. Open cluster stars have been identified in the APOGEE and GALAH spectroscopic surveys by cross-matching their latest data releases with stars for which high-probability astrometric membership has been derived in many clusters on the basis of the Gaia second data release.
Results. Radial velocities were determined for 131 and 14 clusters from APOGEE and GALAH data, respectively. This is the first radial-velocity determination from high-resolution spectra for 16 systems. Iron abundances were obtained for 90 and 14 systems from APOGEE and GALAH samples, respectively. To our knowledge 66 of these clusters (57 in APOGEE and 9 in GALAH) do not have previous determinations in the literature. For 90 and 7 clusters in the APOGEE and GALAH samples, respectively, we also determined average abundances for Na, Mg, Al, Si, Ca, Cr, Mn, and Ni.
iTRAQ-based comparative proteomic analysis of cells infected withEimeria tenellasporozoites
Authors: Zhao Zongping , Zhao Qiping , Zhu Shunhai , Huang Bing , Lv Ling , Chen Ting , Yan Ming , Han Hongyu , Dong Hui 
Published: February 2019

Eimeria tenellais an obligate intracellular parasite that actively invades cecal epithelial cells of chickens. WhenE. tenellainfects a host cell, the host produces a corresponding change to deal with damage caused by this infection. To date, our knowledge on the mechanism of how the host cell responds toE. tenellainfection is highly limited at both the molecular and cellular levels. In this study, isobaric tags for relative and absolute quantitation (iTRAQ) coupled with LC-MS/MS was used to screen the differentially expressed proteins (DEPs) in BHK-21 cells infected withE. tenellasporozoites for 24 h post infection. In total, 6139 non-redundant distinct proteins were identified and 195 of these were found to have a fold change ratio ≥1.3 or ≤0.7 andp < 0.05, including 151 up-regulated proteins and 44 down-regulated proteins. The reliability of the proteomic data was further validated with qPCR and western blot. Gene Ontology enrichment indicated that the up-regulated DEPs were mainly involved in binding and catalytic activity, whereas the down-regulated DEPs were catalytic activity and molecular function regulators. Furthermore, KEGG pathway analysis showed that the DEPs participated in the PI3K-Akt, chemokine, Ras, Wnt, and p53 signaling pathways and so on, and the up-regulated and down-regulated DEPs mainly related to the ribosome and mRNA surveillance pathway, respectively. The data in this study provide an important basis to further analyzeE. tenellahost cell interactions.
Wohlfühlfaktor Wärme
Authors: Eisenberg Jutta , Rischke Andreas 
Published: February 2019

ZusammenfassungVor, während und nach einer Operation sollten Patienten nicht frieren, sondern
stets ihre individuelle Wohlfühltemperatur haben. Lesen Sie, wie es gelingt,
Mitarbeiter und Patienten für das wichtige Thema „Vermeidung von perioperativer
Hypothermie“ zu sensibilisieren und ein entsprechendes Wärmekonzept
umzusetzen.
Serum Brain-derived Neurotrophic Factor Levels Mirror Bone Mineral Density in Amenorrheic and Eumenorrheic Athletes
Authors: Nose Sayaka , Yoshino Osamu , Nomoto Kaori , Harada Miyuki , Dohi Michiko , Kawahara Takashi , Osuga Yutaka , Fujii Tomoyuki , Saito Shigeru 
Published: February 2019

AbstractAmenorrhea and osteoporosis are strongly associated in female athletes. Amenorrheic women show lower serum levels of brain-derived neurotrophic factor (BDNF) than eumenorrheic women. BDNF is known to regulate bone tissue development and remodeling; thus, athletes with low serum BDNF levels may show low bone mass. This study investigated the associations between serum BDNF, estradiol, and bone mineral density (BMD) in female athletes. This study included 160 elite female athletes (21.7±4.3 years). Serum levels of BDNF and estradiol were in 195 blood samples obtained from 132 eumenorrheic athletes (EA) and 63 amenorrheic athletes (AA). BMD was measured in the radius, lumbar spine, pelvis, and legs using dual-energy X-ray absorptiometry. AA showed significantly lower serum BDNF levels than EA (p=0.017). Serum BDNF levels were positively and significantly associated with both serum estradiol levels (p=0.0004) and the BMD measured at all sites (all p<0.05). 10 AA received transdermal estrogen therapy, and serum BDNF levels were measured at baseline and 6 months after therapy. Hormone-treated AA demonstrated a significant increase in serum BDNF levels after 6 months (p=0.022). Thus, serum BDNF levels may be associated with decreased BMD and serve as an indicator of the therapeutic effect of estradiol supplementation in female athletes with osteoporosis.
Deoxygenative Transformation of Carbonyl and Carboxyl Compounds Using gem-Diborylalkanes
Authors: Hu Yue , Sun Wei , Liu Chao 
Published: February 2019

gem-Diborylalkanes serve as privileged carbanion precursors for the efficient construction of carbon–carbon bond with various carbonyl and carboxyl compounds. We highlight the recent advances on deoxygenative transformation of carbonyl and carboxyl compounds using gem-diborylalkanes reagents. Our recent development of a dual functionalization of gem-diborylalkanes through deoxygenative enolization with the carboxylic acids is also discussed.1	Introduction2	Activation Modes of gem-Diborylalkanes3	Deoxygenative Transformation of Carbonyl and Carboxyl ­Compounds via α-Diboryl Carbanion3.1	Reaction with Aldehyde and Ketone Electrophiles3.2	Reaction with Carboxylic Acid Derivatives4	Deoxygenative Transformation of Carbonyl and Carboxyl ­Compounds via α-Monoboryl Carbanion5	Conclusion