bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yaratıcı Drama Yönteminin Hayat Bilgisi Dersinde Kullanılmasının Öğrencilerin BaşarılarınaEtkisinin ve Öğrenci Görüşlerinin İncelenmesi
Authors: ÜTKÜR Nur , AÇIKALIN Mehmet 
Published: April 2018

Bu araştırmanın temel amacı, hayat bilgisidersinde yaratıcı
drama yöntemi kullanılmasının
öğrencilerin başarılarına, öğrendiklerinin kalıcı olmasına ve bu şekilde
işlenen derslere yöneliköğrenci görüşlerinin incelenmesidir. Nitel ve nicel
veri toplama yöntemlerinin birlikte kullanıldığı karma araştırma metodolojisine
dayalı bu araştırmanın örneklemini, rastgele olarak deney ve kontrol grubu
seçilen 3. sınıf öğrenci şubeleri oluşturmaktadır. Bu şubelerin ön-test
sonuçları ve hayat bilgisiders notları
arasında anlamlı bir fark bulunmamaktadır.
Gruplara toplam 16 saat olan eğitim verilmiş olup, bu eğitim deney
grubundaki öğrencilere yaratıcı drama yöntemiyle, kontrol grubundaki
öğrencilere ise İlkokul hayat bilgisi 3. sınıf ders kitabında yer alan yöntem
ve teknikler doğrultusunda (soru-cevap, tartışma) uygulanmıştır. On altı saatlik uygulama
sonrasında nicel veri toplamak amacıyla, gruplara son-test ve altı ay sonra
kalıcılık testi uygulanmış, grupların başarıları arasında anlamlı fark olup olmadığına
bakılmıştır. Ayrıca deney grubundaki öğrencilerin yaratıcı drama ile işlenen
derslere yönelik görüşlerini öğrenebilmek amacıyla, açık uçlu anket uygulanmış
ve bu gruptaki öğrenciler arasından seçilen altı kişiyle görüşme yapılmıştır.
Elde edilen bulgulardaki son-test ve kalıcılık testleri sonuçlarında deney
grubu lehine anlamlı fark olduğu, deney grubundaki öğrencilerin uygulama
sonrasındaki başarılarının kontrol grubundaki öğrencilerin başarılarından
yüksek olduğu ve deney grubundaki öğrencilerin kontrol grubundakilere göre
öğrendikleri bilgilerin daha kalıcı olduğu tespit edilmiştir. Ayrıca deney
grubundaki öğrencilerin derslere yönelik görüşlerinin olumlu olduğu, yaratıcı
dramayı sevdikleri ve bu şekilde işlenen dersleri daha iyi anladıkları ortaya
konulmuştur.
Study of prevalence and clinical spectrum of seizures in children in a teaching hospital in rural Telangana, India
Authors: Sastry C. P. V. Ramana , Reddy R. Manohar 
Published: April 2018

Background: To study the prevalence and clinical spectrum of seizures and treatment outcome in children.Methods: A hospital based prospective study was done at Maheshwara Medical College and Hospital, Patancheru, Telangana in the department of Paediatrics over one-year period. A total of 75 cases presenting with seizures were studied for demographics, clinical features, imaging studies where possible and patient response to treatment. Results: T Patient age ranged from one week to 14 years with male to female ratio of 1:4. Majority were in the age group of 1-3 years 25/75 (33.3%). Fever was present on admission in 66.6% of cases in 1 month to 6 years. Unprovoked seizure was common 20/75 (26.6%) in age group 6 to14 years. Neonatal seizures were seen in 6.6% cases. Generalized tonic clonic seizures were common and were seen in 63.3% cases. Only 5 (6.6 %) cases presented with status epilepticus. CT scan was done in 20 cases in unprovoked seizures and showed various etiologies. Conclusions: Seizures in children are a common indication for hospital admission. They can be febrile or unprovoked. CNS infections and space occupying lesions are common causes for paediatric seizures. Early detection of the cause of seizures helps in instituting appropriate treatment. Children with unprovoked seizures should be on regular long term follow up and treatment.
The effect of Kangaroo Mother Care (KMC) on breast feeding at the time of NICU discharge
Authors: C. D. Tharashree , M. R. Shravani , S. Srinivasa 
Published: April 2018

Background: The WHO has defined KMC as early, continuous, and prolonged skin-to-skin contact between the mother and preterm babies. Exclusive breastfeeding is one of the most important essential components of Kangaroo Mother Care in preterm babiesMethods: This a cross sectional study, 265 consecutive premature newborns admitted to neonatal intensive care unit (NICU) between May 2015 and May 2016 in KIMS NICU Hospital in Bengaluru were evaluated. All of candidate mothers were educated for KMC and compared with a CMC group.Results: In this study 159 mothers performed kangaroo mother care (KMC group) versus 106 in conventional method care (CMC group). In KMC group exclusive breast feeding was 99 (65.2%) versus 40 (37.7%), and P = .00 in CMC group, at the time of hospital discharge. Receiving KMC, and gestational age were the only effective factors predicting exclusive breastfeeding. Present result indicated that there was a 2.7 time increase in exclusive breastfeeding by KMC, and also weekly increase in gestational age increased it 0.9 times, but maternal age, birth weight, mode of delivery, and 5-minute Apgar score had no influence.Conclusions: KMC is more effective, and increases exclusive breast feeding successfully. It can be a good substitution for CMC (conventional methods of care). It is a safe, effective, and feasible method of care for LBWI even in the NICU settings.
Concerns that Linger: Medical School Perspectives on the UKMLA and Shared Assessment
Authors: MacDougall Margaret 
Published: April 2018

The General Medical Council have closed their formal consultation process soliciting recommendations on how to develop a UK Medical Licensing Assessment (UKMLA). The output of this consultation goes a considerable way to identifying concerns about implementation of such an assessment. However, there is scope for more attention to detail in specifying concerns held by individual UK medical schools, even where these schools have indicated acceptance or approval of the UKMLA. There is therefore a need for increased transparency in identifying stakeholder viewpoints to ensure these lingering concerns can be addressed during the current development phase. The current study contributes to addressing this need through providing an overview of UK medical school views on introducing a UKMLA and relatedly, on shared assessment as a source of uniformity in competency across medical schools. Using a secure online survey system, response data were collected during 13-30 January, 2014 from recommended assessment specialists, representing their respective medical schools. Likert scale and free text response data were collected. Based on Likert sale data, more medical schools appeared accepting of these ideas than either those who expressed disapproval or those who expressed uncertainty. Nevertheless, concerns still lingered. Areas of concern included stifling of curriculum innovation, supporting students who fail the UKMLA and quality and administration of assessment. Eleven recommendations have emerged for addressing respondent concerns. In presenting these recommendations arising specifically from participant feedback, I invite responses from all categories of stakeholder in order to promote open discussion beyond the formal consultation period.
Effect of different hydrolytic enzymes pretreatment for improving the hydrolysis and biodegradability of waste activated sludge
Authors: Chen Jiahao , Liu Shihu , Wang Yingmu , Huang Wei , Zhou Jian 
Published: April 2018

Abstract
In this study, the effects of lysozyme, protease and α-amylase pretreatments for improving the hydrolysis and biodegradability of waste activated sludge (WAS) were investigated. The results showed that lysozyme was more effective in increasing the soluble chemical oxygen demand (SCOD) concentration in the liquid phase of sludge and improving the release of protein and carbohydrate from sludge flocculation to enhance sludge hydrolysis. After 8 h hydrolysis, the net SCOD increase in a reactor with lysozyme was 2.23 times and 2.15 times that of the reactors with protease and α-amylase, respectively. Meanwhile, lysozyme and protease could improve the lysis of microorganism cells and the dissolution of extracellular polymeric substances (EPS) to a certain extent, and lysozyme was more effective. Furthermore, the compositional characteristics of dissolved organic matter (DOM) and EPS were analyzed by EEM fluorescence spectroscopy and fluorescence regional integration (FRI) analysis. Tryptophan-like protein was the main component of sludge, which accounted for 31% and 38% of DOM and EPS, respectively. Lysozyme could decrease the percentage of non-biodegradable materials in sludge, such as humic acid-like substances and fulvic acid-like substances, so it could improve the biodegradability of sludge. This study can provide valuable information for future studies about hydrolytic enzyme pretreatments for WAS disposal.
Polymer Conjugated Gold Nanoparticles in Biomedical Applications
Authors: Anniebell Stanley , Gopinath Subash C.B. 
Published: April 2018

Background:
Research interest on the properties of polymer conjugated gold
nanoparticle (GNP) in biomedicine is rapidly rising because of the extensive evidences for
their unique properties. In the field of biomedicine, GNPs have been widely used because of
their inertness and low levels of cytotoxicity. Therefore, when exposed to cells, they are less
prone to exert damaging effects. GNPs are capable of being functionalized as desired and are
ideal as they do not encourage undesired side reactions that might counter react with the intention
of the functionalization. Biofouling is an occurrence that takes place at cellular and
biological molecular level, binds non-specifically on the detection surface and forms a wrong
output. This undesired incidence can be avoided by conjugating the surface of biomolecules
with polymers. Densely packed repeating chains of polymers such as polyethylene glycol are
capable of decreasing non-specific reactions. Applications of polymer conjugated GNPs in
the field of biomedicine are as biosensors, delivery and therapeutic agents.

Conclusion:
Therefore, the properties and applications of polymer conjugated GNPs are
studied widely as overviewed here.
Synthesis of 1,3-benzoxazines Based on 2,4,4-trimethyl-7,2’,4’-trihydroxy Flavan: Antibacterial, Anti-inflammatory, Cyclooxygenase-2 Inhibition and Molecular Modelling Studies
Authors: Mohammed Issam A. , Ahmed Mahmood , Ikram Rabia , Muddassar Muhammad , Qadir Muhammad Abdul , Binti Awang Khalijah 
Published: April 2018

Background:
In the present study, the formation of 2, 4, 4-trimethyl-7,2’4’-trihydroxy
flavan has been used as the key feature for the formation of new 1,3-benzoxazines. This reaction
was carried out via Mannich-condensation reaction, the 7-hydroxy group of flavan was reacted with
different primary amines in the presence of formaldehyde.

Methods:
All the synthesized compounds were characterized on the basis of FT-IR, NMR, MS and
elemental analysis (CHN). Disk diffusion and 96-well plate assay methods were employed for the
zone of inhibition and minimum inhibitory concentration determination, respectively to investigate
the antibacterial activities.

Results and Conclusion:
Our studies showed that compound with electron withdrawing group on
the benzene ring of 1,3-benzoxazines has promising antibacterial activities. An oral dose of
10 mg/kg body weight was administered to albino mice for acute toxicity of synthesized compounds.
In vivo anti-inflammatory and in-vitro cyclooxygenase-2 (COX-2) studies showed that
compound 11 was the most potent anti-inflammatory agent which inhibited induced edema by
62.7% while 68.7% inhibition of COX-2 was observed. The plausible binding mode of this compound
in COX-2 enzyme was also determined using molecular docking simulations.
Produksi imunoglobulin Y (IgY) untuk pengembangan metode deteksi dini kontaminasi okratoksin (Immunoglobulin Y (IgY) production to develop an early detection method for ochratoxin contamination)
Authors: KRESNAWATY Irma , SUHARYANTO . , SISWANTO . , HUDIYONO Sumi 
Published: April 2018

Indonesian coffee and cocoa commodities are constrained by low product quality problem due to contamination of fungal metabolites which producing ochratoxin A (OTA). Ochratoxin is neprotoxic, immunogenic, carcinogenic and teratogenic to the human health. Early detection method on site detection should be developed because of those negative effects. The aim of this study was to produce antibody to develop a method for OTA detection. Antibody was produced by immunization of egg laying hen. Antibody-produced was sepatared and analyzed using ELISA (Enzyme-Linked Immunosorbent Assay) and DBIA (dot blot immunoassay),and tested its composition using HPLC and SDS PAGE. The results showed that anti-OTA polyclonal antibodies had been obtained already from chicken eggs in the 4th period (7 weeks after initial immunization). These antibodies showed anti-OTA reactivity by DBIA method and still showed anti-OTA reactivity up to 9th period (12 weeks after initial immunization). The anti-BSA antibodies produced should be removed to increase the sensitivity of antibodies againts ochratoxin A. The separation of BSA antibodies can be conducted by the absorption of the protein. [Keywords: ochratoxin A; early detection; antibody IgY]. AbstrakKomoditas kopi dan kakao Indonesia terkendala masalah mutu produk yang rendah akibat kontaminasi cendawan penghasil okratoksin A. Okratoksin A (OTA) bersifat neprotoksik, imunogenik, karsinogenik dan teratogenik yang membahayakan kesehatan manusia. Karena efek negatif yang diakibatkan oleh mikotoksin ini, maka perlu dikembangkan deteksi dini kontaminasi okratoksin langsung di lokasi. Penelitian ini bertujuan menghasilkan antibodi imunoglobulin Y (IgY) untuk mengembangkan metode perakitan perangkat deteksi cepat berbasis imunologi untuk deteksi OTA. Antibodi dihasilkan menggunakan uji ayam petelur. Antibodi yang dihasilkan dipisahkan dan dianalisis aktivitasnya dengan ELISA (Enzyme-Linked Immunosorbent Assay) dan DBIA (dot blot immunoassay), serta diuji komposisinya dengan HPLC dan SDS PAGE. Hasil penelitian menunjukkan bahwa antibodi poliklonal anti-OTA sudah diperoleh dari telur ayam pada periode ke-4 (7 minggu setelah imunisasi awal). Antibodi ini menunjukkan reaktivitas anti-OTA dengan metode DBIA dan masih menunjukkan reaktivitas anti-OTA sampai periode 9 (12 minggu setelah imunisasi awal). Komposisi asam amino antibodi anti-OTA menunjukkan perbedaan dengan komposisi asam amino IgY di database. Antibodi anti BSA yang dihasilkan harus dihilangkan terlebih dahulu untuk meningkatkan sensitivitas antibodi terhadap okratoksin A dan pemisahan dapat dilakukan dengan penyerapan antibodi BSA.[Kata Kunci: okratoksin A; deteksi dini; antibodi IgY].
The Role of Sell-Side Analysts after Accusations of Managerial Misconduct
Authors: Jennings Jared 
Published: April 2018

ABSTRACT
Prior research questions the general informational role of analysts by documenting inefficiencies, biases, and limitations of their research. Rather than examine the general informational value of analyst research, I examine the value of analyst research in a specific setting—shareholder lawsuits—when investors demand information but other information providers are limited in their ability to provide it. After the lawsuit's filing, the demand for and production of management-provided information decreases. I argue that analysts are uniquely qualified to provide a portion of the information demanded by investors after the lawsuit's filing. I find evidence consistent with analysts providing more research that is more informative after the lawsuit's filing. This study provides contrasting evidence to the literature that is critical of analysts by documenting that analysts are able to produce useful information when investors demand it, despite a potential reduction in the demand for or production of management-provided information.
JEL Classifications: G11; G14; G18; G24; K20; K22; M41.
Eighteen-month Clinical Study of Universal Adhesives in Noncarious Cervical Lesions
Authors: Ruschel VC , Shibata S , Stolf SC , Chung Y , Baratieri LN , Heymann HO , Walter R 
Published: April 2018

SUMMARY

Objective:
To evaluate the clinical performance of Scotchbond Universal (3M Oral Care) and Prime & Bond Elect (Dentsply Sirona) in the restoration of noncarious cervical lesions (NCCLs).

Methods and Materials:
This was a randomized controlled clinical trial involving 63 subjects. Two hundred and three NCCLs were restored using Scotchbond Universal and Prime & Bond Elect using both an etch-and-rinse and a self-etch technique. Lesions were notch-shaped NCCLs, and the restorations were placed without any mechanical retention. Restorations were finished immediately after placement and scored with regard to retention, marginal discoloration, marginal adaptation, and secondary caries. Similar assessment of the restorations was performed 18 months after placement. Logistic regression was performed for each outcome separately with a compound symmetric variance-covariance structure assumed to consider a correlation of restorations within subjects. All analyses were conducted using SAS version 9.4 (SAS Inc).

Results:
One hundred and fifty-eight teeth (77.8% of the restorations placed) in 46 subjects (73% of subjects enrolled) were available for the 18-month follow-up. A statistically significant difference was reached only for the comparison Scotchbond Universal/self-etch (SU_SE) and Prime & Bond Elect/etch-and-rinse (PBE_E&R) groups (p=0.01), where a restoration with SU_SE was 66% less likely to maintain a score of Alpha for marginal discoloration than a restoration performed with PBE_E&R.

Conclusions:
Scotchbond Universal and Prime & Bond Elect presented acceptable clinical performance after 18 months of clinical service. However, Scotchbond Universal, when applied with a self-etch approach, did demonstrate a relatively high level of marginal discoloration when compared to the other groups.
Elaboração e implantação de procedimento de solicitação de medicamentos manipulados personalizados
Authors: Reis Guimarães Ana Carolina , Marostegam Priscila Faria Franca , Chaves Cleuber Esteves , Pinto Vanusa Barbosa 
Published: April 2018

Resumo: O intuito da farmacotécnica é contribuir com as demais áreas da farmácia hospitalar, para que esta atenda suas atividades de serviço clínico e auxilie o atendimento ao paciente hospitalizado. Para que o paciente possa usufruir de um serviço de qualidade é necessário um sistema gerencial que reconheça suas necessidades e estabeleça padrões para assegurar a satisfação e recuperação do mesmo. Objetivo: Sistematizar o procedimento de solicitação de medicamentos manipulados. Método: Trata-se de um estudo descritivo, realizado no Setor de Manipulação da Unidade de Farmacotécnica Hospitalar. Foi realizada uma reunião com farmacêuticos participantes para apresentação e validação da ferramenta. Posteriormente foi elaborado um procedimento operacional padrão (POP), fluxograma e formulário de solicitação de medicamento manipulado. O mesmo era preenchido pelos farmacêuticos da central de avaliação de prescrição (CAP) e da assistência farmacêutica à internação (AFI) e encaminhado ao setor de manipulação, onde era feita a análise da viabilidade de manipulação do medicamento. Após a avaliação, a resposta era registrada em uma planilha Microsoft Office Excel® e compartilhada com o profissional solicitante. Ao final da pesquisa foi aplicado um questionário de satisfação para os farmacêuticos solicitantes. Resultados: No período de estudo houve um total de 26 solicitações de medicamentos manipulados, os quais foram requisitados em sua maioria pela AFI, representando 58% (15) dos pedidos. A clínica com o maior número de requisições de medicamentos manipulados foi a UTI da Divisão de Clínica Neurológica com 19% (5) das solicitações. A classe farmacoterapêutica mais solicitadas de acordo com a classificação a Anatomical Therapeutic Chemical (ATC) foi a de antibacterianos para uso sistêmico, representando 27% (7) dos medicamentos solicitados. Dos 26 medicamentos solicitados 81% (21) foram manipulados. O prazo de entrega dos medicamentos variou de 0 a 3 dias, sendo 57% (12) solicitações manipuladas e atendidas no mesmo dia. A via de administração em que houve o maior número de solicitações foi a oral com 38% (8). Os farmacêuticos demonstraram sua opinião quanto a ferramenta utilizada, avaliando atributos presentes no questionário de satisfação. Obteve-se um retorno de 64% dos questionários de satisfação. Destaca-se positivamente a avaliação dos farmacêuticos relacionada aos quesitos presentes no questionário, em que 100% dos farmacêuticos disseram que a ferramenta proposta deve ser implantada na rotina. Conclusão: A análise dos dados deste trabalho permitiu concluir que a ferramenta proposta para solicitação de medicamentos manipulados é considerada satisfatória e atende às expectativas dos usuários, ainda que algumas alterações e ajustes se façam necessárias. PALAVRAS CHAVE: Medicamento manipulado, otimização de processos, farmácia hospitalar, boas práticas de manipulação.
When Brand Familiarity Breeds Risk: The Curse of Negative Knowledge
Authors: Walker Chip 
Published: April 2018

Abstract
In today’s world, knowing more about a brand can make people think worse of it. Rather than helping a brand, increased familiarity can actually add risk. This is a phenomenon referred to as “negative knowledge.” It happens when the more consumers know about a brand, the less they like it. Possible reasons can be that consumers feel embarrassed by the brand, that they have bad brand experiences or learn about them in the media or from friends, or that they dislike a company’s business motives.
Once consumers know something about a brand, it is hard for them to “un-know” it. During a time of media fragmentation when all managers are struggling to gain more fame for their brands, it’s critical to realize that brand knowledge comes with a potential dark side. While it’s always wise to avoid brand obscurity, marketers must be ever cognizant that what customers know about a brand really can do more harm than good.
How Consumers’ Styles of Thinking Can Control Brand Dilution
Authors: Monga Alokparna Basu , Hsu Liwu 
Published: April 2018

Abstract
Understanding consumers’ ways of thinking can help identify strategies to limit brand damage and elicit more favorable reactions from disapproving consumers. Analytic thinkers’ beliefs about a brand are diluted when they see negative information; those of holistic thinkers remain unaffected. While both analytic and holistic thinkers blame the brand equally for quality and manufacturing problems, holistic thinkers are more likely to blame contextual factors outside of the brand than analytic thinkers. This ability of holistic thinkers to focus on the outside context is the reason why their brand beliefs are not diluted.
State-of-the-art crisis management should be proactive vis-à-vis potentially negative events. Crisis communications that highlight contextual factors as triggers of negative incidents offer a powerful mechanism to restrict brand damage. Additionally, elaborational messages that clarify the nature of the brand extension can curb negative thoughts from analytic consumers and boost their responses.