bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Heart Failure developed as worsening of Chronic Heart Failure is associated with increased mortality compared to de novo cases
Authors: Degoricija Vesna , Trbušić Matias , Potočnjak Ines , Radulović Bojana , Terešak Sanda Dokoza , Pregartner Gudrun , Berghold Andrea , Tiran Beate , Frank Saša 
Published: June 2018

AbstractAcute heart failure (AHF) emerges either de novo or from worsening of chronic heart failure (CHF). The aim of the present study was to evaluate the association between worsening of CHF and mortality in AHF patients. Out of 152 included AHF patients, 47 (30.9%) were de novo AHF patients and 105 (69%) were AHF patients with worsening of CHF. The proportion dying in hospital (19.0% vs. 4.3%, p = 0.023) and within 3 months after hospitalization (36.6% vs. 6.7%, p < 0.001) was significantly higher in AHF patients with worsening of CHF. Logistic regression analyses also showed a significant positive association of AHF emerging as worsening of CHF with hospital mortality [odds ratio (OR) and 95% confidence interval (CI): 5.29 (1.46–34.10), p = 0.029] and 3-month mortality [8.09 (2.70–35.03), p = 0.001]. While the association with hospital mortality was no longer significant after adjusting for comorbidities and clinical as well as laboratory parameters known to be associated with mortality in heart failure patients, the association with 3-month mortality remained significant. We conclude that compared to de novo AHF, AHF evolved from worsening of CHF is a more severe condition and is associated with increased mortality.
Comparative study of plasmonic antennas fabricated by electron beam and focused ion beam lithography
Authors: Horák Michal , Bukvišová Kristýna , Švarc Vojtěch , Jaskowiec Jiří , Křápek Vlastimil , Šikola Tomáš 
Published: June 2018

AbstractWe present a comparative study of plasmonic antennas fabricated by electron beam lithography and direct focused ion beam milling. We have investigated optical and structural properties and chemical composition of gold disc-shaped plasmonic antennas on a silicon nitride membrane fabricated by both methods to identify their advantages and disadvantages. Plasmonic antennas were characterized using transmission electron microscopy including electron energy loss spectroscopy and energy dispersive X-ray spectroscopy, and atomic force microscopy. We have found stronger plasmonic response with better field confinement in the antennas fabricated by electron beam lithography, which is attributed to their better structural quality, homogeneous thickness, and only moderate contamination mostly of organic nature. Plasmonic antennas fabricated by focused ion beam lithography feature weaker plasmonic response, lower structural quality with pronounced thickness fluctuations, and strong contamination, both organic and inorganic, including implanted ions from the focused beam. While both techniques are suitable for the fabrication of plasmonic antennas, electron beam lithography shall be prioritized over focused ion beam lithography due to better quality and performance of its products.
Inverse association between soy food consumption, especially fermented soy products intake and soy isoflavone, and arterial stiffness in Japanese men
Authors: Uemura Hirokazu , Katsuura-Kamano Sakurako , Nakamoto Mariko , Yamaguchi Miwa , Fujioka Miho , Iwasaki Yuki , Arisawa Kokichi 
Published: June 2018

AbstractStudies on the associations between soy food consumption and arterial stiffness are rare. The aim of the present study was to evaluate their associations in Japanese men. A total of 652 eligible men, aged 35–69 years, who underwent the measurement of brachial-ankle pulse wave velocity (baPWV) as an index of arterial stiffness were evaluated in this cross-sectional study. Information on their lifestyle characteristics, including dietary behavior, was obtained from a structured self-administered questionnaire. The frequency of total soy products as well as fermented and non-fermented soy products intakes was calculated, and the amounts of soy protein and soy isoflavone intakes were also estimated; these were then divided into tertiles and their associations with baPWV values were evaluated using general linear models. Higher frequency of fermented soy products intake was associated with decreased baPWV after adjusting for the multivariable covariates (P value for trend was 0.002, in Model 3). This association did not alter after further adjustment with a biomarker of systemic inflammation (serum high-sensitivity C-reactive protein (hs-CRP)) (P value for trend was 0.001, in Model 4). Total soy isoflavone consumption was also inversely associated with baPWV even after adjusting for multivariable covariates including serum hs-CRP (P value for trend was 0.043, in Model 4); however total soy protein consumption was not. These results demonstrated that greater consumption of soy food, especially fermented soy products and soy isoflavone was associated with reduced arterial stiffness, independent of systemic inflammation, in Japanese men.
Angular- and Polarization-insensitive Ultrathin Double-layered Metamaterial Absorber for Ultra-wideband Application
Authors: Cong Li Li , Cao Xiang Yu , Song Tao , Gao Jun , Lan Jun Xiang 
Published: June 2018

AbstractWe proposed an ultra-thin polarization-insensitive metamaterial absorber (MMA) for ultra-wideband and wide incident angle operation. The MMA is composed of double-layer symmetric split rings (SSRs) connected with two orthogonally-arranged bars and the ground metallic plane separated by two identical substrates. Multiple metallic layers and scalabilities are employed to provide broadband absorptivity based on the cooperated mechanisms of the Ohmic loss and the Fabry-Perot interference. To further broaden the absorption bandwidth, four lumped resistors are loaded with the SSRs on the top metallic layer. By this means, an ultra-wideband absorbance is achieved nearly in 4~22 GHz, two gentle slope belts with absorptivity over 60% and 80% in 4~12 GHz and 12~22 GHz, respectively. The whole structure is with an ultrathin thickness of 2.4 mm, which is 0.032λlow and 0.176λhigh corresponds to the lowest and highest absorption frequency separately. Meanwhile, the symmetric structure enables the MMA of satisfactory stability for polarization and wide incident angles. Numerical and experimental results prove the capability of the proposed MMA for ultra-wideband absorbance.
Warping an atlas derived from serial histology to 5 high-resolution MRIs
Authors: Tullo Stephanie , Devenyi Gabriel A. , Patel Raihaan , Park Min Tae M. , Collins D. Louis , Chakravarty M. Mallar 
Published: June 2018

AbstractPrevious work from our group demonstrated the use of multiple input atlases to a modified multi-atlas framework (MAGeT-Brain) to improve subject-based segmentation accuracy. Currently, segmentation of the striatum, globus pallidus and thalamus are generated from a single high-resolution and -contrast MRI atlas derived from annotated serial histological sections. Here, we warp this atlas to five high-resolution MRI templates to create five de novo atlases. The overall goal of this work is to use these newly warped atlases as input to MAGeT-Brain in an effort to consolidate and improve the workflow presented in previous manuscripts from our group, allowing for simultaneous multi-structure segmentation. The work presented details the methodology used for the creation of the atlases using a technique previously proposed, where atlas labels are modified to mimic the intensity and contrast profile of MRI to facilitate atlas-to-template nonlinear transformation estimation. Dice’s Kappa metric was used to demonstrate high quality registration and segmentation accuracy of the atlases. The final atlases are available at https://github.com/CobraLab/atlases/tree/master/5-atlas-subcortical.
MEG-BIDS, the brain imaging data structure extended to magnetoencephalography
Authors: Niso Guiomar , Gorgolewski Krzysztof J. , Bock Elizabeth , Brooks Teon L. , Flandin Guillaume , Gramfort Alexandre , Henson Richard N. , Jas Mainak , Litvak Vladimir , T. Moreau Jeremy , Oostenveld Robert , Schoffelen Jan-Mathijs , Tadel Francois , Wexler Joseph , Baillet Sylvain 
Published: June 2018

AbstractWe present a significant extension of the Brain Imaging Data Structure (BIDS) to support the specific aspects of magnetoencephalography (MEG) data. MEG measures brain activity with millisecond temporal resolution and unique source imaging capabilities. So far, BIDS was a solution to organise magnetic resonance imaging (MRI) data. The nature and acquisition parameters of MRI and MEG data are strongly dissimilar. Although there is no standard data format for MEG, we propose MEG-BIDS as a principled solution to store, organise, process and share the multidimensional data volumes produced by the modality. The standard also includes well-defined metadata, to facilitate future data harmonisation and sharing efforts. This responds to unmet needs from the multimodal neuroimaging community and paves the way to further integration of other techniques in electrophysiology. MEG-BIDS builds on MRI-BIDS, extending BIDS to a multimodal data structure. We feature several data-analytics software that have adopted MEG-BIDS, and a diverse sample of open MEG-BIDS data resources available to everyone.
Intrinsic Laryngeal Muscle Response to a Public Speech Preparation Stressor
Authors: Helou Leah B. , Rosen Clark A. , Wang Wei , Verdolini Abbott Katherine 
Published: June 2018

PurposeResearch suggests that abnormal levels of intrinsic laryngeal muscle (ILM) contraction is a potential causal factor in stress-induced voice disorders. This study seeks to characterize the ILM stress response in a cohort of vocally healthy women.MethodThe authors used an unblinded, nonrandomized, repeated-measures design. Forty vocally healthy female adults were subjected to a stressful speech preparation task. Measurements of heart rate, blood pressure, trapezius muscle (positive control) activation, and tibialis muscle (negative control) activation were obtained from 37 participants before and during stressor exposure, in a nonvoice and nonspeaking task paradigm, to confirm physiological stress response compared to baseline. Fine wire electromyography of the ILMs (posterior cricoarytenoid, thyroarytenoid/lateral cricoarytenoid muscle complex, and cricothyroid) was performed simultaneously so that the activity of these muscles could be measured prior to and during stressor exposure.ResultsThe protocol successfully elicited the typical and expected physiological stress responses. Findings supported the hypothesis that, in some individuals, the ILMs significantly increase in activity during stress reactions compared to baseline, as do the control muscles.ConclusionsThis study characterizes ILM responses to psychological stress in vocally healthy participants. Some of the female adults in this study appeared to be “laryngeal stress responders,” as evidenced by increased activity of the ILMs during a silent (i.e., nonvocal, nonspeech) speech preparation task that they considered to be stressful.
Phase noise as power characteristic of individual appliance for non‐intrusive load monitoring
Authors: Lee D. 
Published: June 2018

Phase noise, a unique characteristic of electrical appliances, for non‐intrusive load monitoring (NILM) is proposed. NILM is a technique, which can distinguish the power consumption of an individual electrical appliance, without requiring the installation of sensors on the appliance, reducing the number of sensors required in an energy management system. It utilises the previously‐recorded power supply characteristics of individual appliances and measures the changes in the bus voltage or current, which provide power supply to several appliances, thereby distinguishing the operational appliances without direct measurement. Considering electrical appliances that can be commonly found in a laboratory, such as an electric drill, soldering iron, and light bulb, the authors found that, when each was turned on, the current at an offset of 5 Hz from the centre frequency of 60 Hz was 61.4, 18.8, and 6.2 mA for each appliance, respectively. As each appliance was turned on in the sequence, the bus current providing electrical energy to all three appliances was measured to be 60.4, 11.1, and 5.7 mA, respectively. Thus, it was experimentally confirmed that the current at frequencies near the centre frequency, i.e. the phase noise, can be used for NILM.
The McDonald Observatory search for pulsating sdA stars
Authors: Bell K. J. , Pelisoli I. , Kepler S. O. , Brown W. R. , Winget D. E. , Winget K. I. , Vanderbosch Z. , Castanheira B. G. , Hermes J. J. , Montgomery M. H. , Koester D. 
Published: June 2018

Context. The nature of the recently identified “sdA” spectroscopic class of stars is not well understood. The thousands of known sdAs have H-dominated spectra, spectroscopic surface gravity values between main sequence stars and isolated white dwarfs, and effective temperatures below the lower limit for He-burning subdwarfs. Most are likely products of binary stellar evolution, whether extremely low-mass white dwarfs and their precursors or blue stragglers in the halo.
Aims. Stellar eigenfrequencies revealed through time series photometry of pulsating stars sensitively probe stellar structural properties. The properties of pulsations exhibited by sdA stars would contribute substantially to our developing understanding of this class.
Methods. We extend our photometric campaign to discover pulsating extremely low-mass white dwarfs from the McDonald Observatory to target sdA stars classified from SDSS spectra. We also obtain follow-up time series spectroscopy to search for binary signatures from four new pulsators.
Results. Out of 23 sdA stars observed, we clearly detect stellar pulsations in 7. Dominant pulsation periods range from 4.6 min to 12.3 h, with most on timescales of approximately one hour. We argue specific classifications for some of the new variables, identifying both compact and likely main sequence dwarf pulsators, along with a candidate low-mass RR Lyrae star.
Conclusions. With dominant pulsation periods spanning orders of magnitude, the pulsational evidence supports the emerging narrative that the sdA class consists of multiple stellar populations. Since multiple types of sdA exhibit stellar pulsations, follow-up asteroseismic analysis can be used to probe the precise evolutionary natures and stellar structures of these individual subpopulations.
Vorausschauende Behandlungsplanung und Therapiebegrenzung
Authors: Winkler Eva , Heußner Pia 
Published: June 2018

ZusammenfassungEntscheidungen zur Therapiebegrenzung sind wichtig, um eine Übertherapie am Lebensende zu verhindern. Sie gehen heute mehr als der Hälfte der erwarteten Todesfälle voraus, werden aber vorher nicht immer mit den Patienten besprochen. Grund hierfür ist, dass selten Gespräche stattfinden, die Entscheidungen am Lebensende vorbereiten und dabei Patientenpräferenzen für die letzte Lebensphase in Erfahrung bringen. Dabei gibt es mittlerweile eine belastbare Evidenz dafür, dass solche Gespräche die Lebensqualität der Patienten verbessern, Angst und Depression reduzieren und dem Patienten eine realistischere Einschätzung seiner Erkrankungssituation ermöglichen, was wiederum Voraussetzung für gemeinsame Entscheidung zur '.In diesem Artikel wird der Begriff „Therapiebegrenzung“ definiert und seine Rechtfertigung aus medizinethischer Sicht begründet. Vor allem aber werden die Ursachen benannt, die derzeit in der medizinischen Versorgung Hinderungsgründe dafür sind, dass eine vorausschauende Behandlungsplanung und Gespräche zur Therapiebegrenzung selten erfolgen. Abschließend werden Lösungsansätze zur Verbesserung der Situation mit ganz praktischen Vorschlägen vorgestellt.
Dialyse bei Diabetes
Authors: Weyrich Peter , Schätzle Gabriele , Maljkovic Mirko , von Gersdorff Gero 
Published: June 2018

ZusammenfassungDer Diabetes mellitus ist trotz besserer Blutzucker- und Blutdruckeinstellung nach wie vor die häufigste Grunderkrankung beim Auftreten einer terminalen
Niereninsuffizienz. Sofern eine Nierentransplantation nicht möglich ist, sind Hämodialyse und Peritonealdialyse bei der diabetischen Dialysepopulation als
gleichwertige Verfahren anzusehen. Dieser Artikel fasst aktuelle epidemiologische, diagnostische und therapeutische Aspekte von Diabetikern an Dialyse
zusammen.
Proline-Catalyzed Asymmetric α-Amination in the Synthesis of Bioactive Molecules
Authors: Kumar Pradeep , Sharma Brijesh 
Published: June 2018

The direct α-amination of carbonyl compounds using organocatalysts represents a powerful and atom-economical tool for asymmetric C–N bond formation. We describe a complete account of α-functionalization of carbonyl compounds, through iterative sequential α-aminoxylation/amination using electrophilic O and N sources, as well as sequential α-amination/HWE reaction for enantio- and diastereoselective synthesis of both syn- and anti-1,3-aminoalcohols and 1,3-diamines. Additionally this protocol is further extended for the easy construction of alkaloids such as indolizidine, pyrrolizidine, and quinolizidine fused-ring systems just by tuning the chain length of the aldehyde used as a starting material. This methodology provides further scope to extrapolate it for a variety of naturally occurring hydroxylated monocyclic and fused bicyclic pyrrolidine and piperidine based alkaloids such as lentiginosine, epi-lentiginosine, dihydroxypyrrolizidine, (+)-deoxoprosophylline and (–)-deoxoprosopinine alkaloids. Furthermore, we have also uncovered proline-catalyzed anti-selectivity for the synthesis of 1,2-amino alcohols in α-amination of aldehyde and one-pot indium-mediated Barbier type allylation of α-hydrazino aldehydes to accomplish the total synthesis of clavaminols, sphinganine and spisulosine with reduced number of steps and with high overall yields.1	Introduction2	Application in the Total Synthesis of Alkaloids3	Conclusion
Hemostasis and Thrombosis in Extreme Temperatures (Hypo- and Hyperthermia)
Authors: Levi Marcel 
Published: June 2018

AbstractThe delicate biochemistry of coagulation and anticoagulation is greatly affected by deviations from the optimal temperature required for the interactions between various coagulation enzymes, cellular receptors, and intracellular mechanisms. Hyperthermia will lead to a prothrombotic state and, if sufficiently severe such as in heatstroke, a consumption coagulopathy, which will clinically manifest with the simultaneous appearance of intravascular thrombotic obstruction and an increased bleeding tendency. Hypothermia slows down the coagulation process, but as this seems to be adequately balanced by impairment of anticoagulant and fibrinolytic processes, its clinical effects are modest; however, hypothermia may be modestly linked to a somewhat higher risk of localized thrombosis. Restoration of a normal body temperature in patients affected by hyper- or hypothermia is the cornerstone for the management of associated coagulation derangements.
Incidence of Guillain–Barre's Syndrome in Children under 15 Years of Age in Oman
Authors: Koul Roshan , Al-Fuitaisi Amna , Macki Nabil , Patel Prakash Kurubarahalli , Al-Balushi Haleema , Al-Abaidani Idris , Al-Abri Seif Salem 
Published: June 2018

Objective Guillain–Barre's syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy seen in all ages but mostly in the adult population. We aim to report the incidence of GBS in children under 15 years of age in Oman, a Gulf country.
Materials and Methods All children with GBS under 15 years of age were included in the study from January 2002 to December 2016. The data were compiled in Microsoft Excel format and analysis was performed using SPSS, version 17.0. Population-based age- and sex-specific rates of GBS were calculated using the estimated population for each 5-year period based on 2004, 2009, and 2014 mid-year population, respectively. Relative risk and 95% confidence intervals of GBS at different age categories were calculated using the overall incidence of GBS in those under 15 years as reference.
Results The average annual incidence in those under 15 years was 3.1/100,000. Age-specific incidence was 4.0/100,000 in the age group 0 to 9 years and 4.7/100,000 in age group 0 to 4 years. Sixty percent had evidence of preceding infections, and the male to female ratio was 1.8:1. Fifty percent had cranial nerve involvement and 18% needed mechanical ventilation. Five percent had residual weakness. Intravenous immunoglobulins (IVIGs) were used in all, and 3.3% required plasmapheresis when they did not improve with IVIG. Clinical profile of the GBS was not different from the rest reported in the literature.
Conclusion The incidence of GBS in Oman was 3.1/100,000 (range: 2.7–3.5 cases/100,000) in children under 15 years of age. The GBS is a smaller proportion among the total acute flaccid paralysis cases.
Repetitive Imaging following Minimally Invasive Repair of Pectus Excavatum Is Unnecessary
Authors: Sola Richard , Yu Yangyang R. , Friske Tyler C. , Jamal Abdur R. , Rosenfeld Eric H. , Mazziotti Mark V. , Peter Shawn D. St. , Shah Sohail R. 
Published: June 2018

Introduction The objective of this study was to evaluate the necessity of repeat imaging after an initial chest radiograph (CXR) following minimally invasive repair of pectus excavatum (MIRPE).
Materials and Methods A retrospective review was performed on patients who underwent MIRPE from January 2012 to July 2016 at two academic children's hospitals. Data collected included demographics, severity of pectus defect (Haller index [HI]), utilization of CXRs, outpatient follow-up, and clinical outcomes.
Results A total of 360 patients (171 at Hospital 1 and 189 at Hospital 2) underwent MIRPE. Median age was 15.6 years and 84% were males. The median HI was 4.0. Median postoperative hospital length of stay was 4.2 days and median time to bar removal was 34 months. There was significant variation in postoperative imaging between the hospitals, including frequency of immediate postoperative CXR, total number of CXRs during hospitalization, and number of postoperative outpatient CXRs prior to bar removal. However, there was no significant difference in outcomes between the hospitals, including postoperative pneumothorax, postoperative chest tube placement, and complications.
Conclusion These data suggest that increased repetitive imaging after an initial postoperative CXR does not affect clinical outcomes and may not be necessary after MIRPE.
Pathologic T Descriptor of Nonmucinous Lung Adenocarcinomas Now Based on Invasive Tumor Size
Authors: Anderson Kevin R , Onken Allison , Heidinger Benedikt H , Chen Yigu , Bankier Alexander A , VanderLaan Paul A 
Published: June 2018

Abstract

Objectives
The eighth edition of the American Joint Committee on Cancer staging manual now stratifies nonmucinous lung adenocarcinomas (nmLACAs) by the size of the invasive component only. This is determined by direct gross or microscopic measurement; however, a calculated invasive size based on the percentage of invasive growth patterns has been proposed as an alternative option.

Methods
To compare radiologic with different pathologic assessments of invasive tumor size, we retrospectively reviewed a cohort of resected nmLACAs with a part-solid appearance on computed tomography (CT) scan (n = 112).

Results
The median direct microscopic pathologic invasive measurements were not significantly different from the median calculated pathologic invasive measurements; however, the median CT invasive measurements were 0.26 cm larger than the median direct pathologic measurements (P < .001).

Conclusions
Our results show that pathologic calculated invasive tumor measurements are comparable to direct microscopic measurements of invasive tumor, thereby supporting the recommendation for use of calculated invasive tumor size by the pathologist if necessary.