bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detoxification and benefits on acute heart failure in mice- of fuziline using glycyrrhetinic acid: an integrated biochemical analysis
Authors: Chang Nianwei , Hou Chunyu , Zhai Yue , Zhang Wenying , Hu Zengmei , Wang Xiaoying 
Published: October 2024

IntroductionAconiti Lateralis Radix Praeparata (lateral roots of Aconitum carmichaelii Debeaux, Fuzi), is commonly used to treat various cardiovascular diseases, particularly heart failure. However, its strong cardiotoxicity limits its clinical applicability. Glycyrrhizae radix et rhizoma, (the root of Glycyrrhiza uralensis Fisch., Gancao), is known to synergistically increase the cardiotonic effects of Fuzi and alleviate the myocardial injury caused by Fuzi to some extent. However, the detailed mechanism via which the combination of Fuzi and Gancao reduces toxicity and increases or preserves the efficacy of Fuzi requires further investigation.MethodsOxidative stress injury models in H9C2 cells and mice with acute heart failure were established to evaluate the optimal synergistic protective concentration of Fuziline and Glycyrrhetinic acid (GA). A GA probe was then synthesized and used for target fishing using chemical and biological methods. Finally, the target and its function were verified using fluorescence co-localization, Western blotting, protein interaction analysis, molecular docking, and calcium ion imaging.ResultsThe best pharmacodynamic potential was achieved with a 1:1 or 2:1 ratio of Fuziline and GA concentrations. At these ratios, they regulated the protein levels of the downstream players of the Ca2+ signaling pathway via MDH2 and CALR, thereby balancing Ca2+ homeostasis in the myocardial tissue and mitigating the effects of heart failure.ConclusionThis study aimed to investigate the compatibility of Fuziline and GA, the active metabolites of a traditional Chinese medicine (TCM) pair, in exerting their cardiac effects, identify the direct biological targets and verify the mechanism of compatibility.
The efficacy and safety of addition of pegylated interferon to long-term nucleos(t)ide analogue therapy on functional cure of chronic hepatitis B patient: a systematic review and meta-analysis
Authors: Zhang Xu , Yang Xianzhao , Tan Lingjie , Tian Yujia , Zhao Zhiren , Ru Shuying 
Published: October 2024

ObjectiveThis meta-analysis aims to assess the efficacy and safety of adding pegylated interferon (Peg-IFN) to long-term nucleos(t)ide analogs (NAs) treatment for achieving functional cure in patients with chronic hepatitis B (CHB).MethodsThis meta-analysis was registered in PROSPERO (CRD42024519116). We searched PubMed, Embase, Cochrane Library and Web of Science for randomized controlled trials that compared adding Peg-IFN to long-term NAs with NAs alone for the treatment of CHB. Relative risks (RR) and 95% confidence interval (CI) were pooled using a random-effects model.ResultsSeven trials with 692 participants were included. Compared to NAs monotherapy, sequential combination therapy significantly increased the HBsAg seroclearance rate (RR 4.37, 95%CI: 1.92–9.55; I2 = 0%) and HBsAg seroconversion rate (RR 3.98, 95%CI: 1.50–10.54; I2 = 0%), and the results reached statistical significance. Compared to NAs monotherapy, sequential combination therapy showed a significant increase in HBeAg seroclearance rate (RR 2.04; 95%CI: 0.47–8.82; I2 = 73%) and HBeAg seroconversion rate (RR 2.10; 95%CI: 0.41–10.71; I2 = 67%), but did not reach statistical significance. Sequential combination therapy was more likely to experience adverse events. Although most reactions are mild and reversible, vigilant monitoring for treatment-related adverse events is essential, with prompt intervention when needed.ConclusionFor CHB patients on long-term NAs treatment, sequential combination therapy boosts HBsAg seroclearance and HBsAg seroconversion rates compared to monotherapy. However, it may increase adverse events. Additional studies are needed to thoroughly evaluate its clinical effectiveness, given the current limited research available.Systematic Review Registration:PROSPERO, identifier CRD42024519116.
Creating demand for unmet needs: Agile Storytelling
Authors: Mehta Jade , Long Emily , Bynagari Vidhur , Shojaei Fereshtehossadat , Shojaei Fatemehalsadat , O’Brien Andrew R. W. , Boustani Malaz 
Published: October 2024

IntroductionThe translational gap from the discovery of evidence-based solutions to their implementation in healthcare delivery organizations derives from an incorrect assumption that the need for change among executive, administrative, or clinical personnel is the same as the demand for change. For sickle cell disease (SCD), implementation of evidence-based guidelines is often delayed or obstructed due to lack of demand. This challenge allows for the persistence of resource limitations and care delivery models that do not meet the community's unique needs. Agile Storytelling is a process built on the scientific foundations of behavioral economics, complexity science, and network science to create local demand for the implementation of evidence-based solutions.MethodsAgile Storytelling includes a design phase and a testing phase. The design phase converts the evidence-based solution into a minimally viable story of a hero, a villain, struggle, drama, and a resolution. The testing phase evaluates the effectiveness of the story via a series of storytelling sprints in the target local healthcare delivery organization. The efficacy of Agile Storytelling was tested in an iterative n-of-1 case study design.ResultsAgile Storytelling was used in a large, urban, healthcare system within the United States to facilitate implementation of national SCD best-practice guidelines. After repeated failures attempting to use national and local data regarding the high societal need to hire a SCD-specific social worker, an Agile change conductor using Agile Storytelling was able to create demand for the new position within a week. This decision has ultimately improved patient outcomes and led to the adoption of a specialized collaborative care team for SCD within the health network.DiscussionAgile Storytelling can lead to structured, effective, and informed storytelling to create local demand within healthcare delivery organizations.
Analyzing postoperative complications in colorectal cancer surgery: a systematic review enhanced by artificial intelligence
Authors: Andras Dan , Lazar Angela Madalina , Crețoiu Dragoş , Berghea Florian , Georgescu Dragos Eugen , Grigorean Valentin , Iacoban Simona Raluca , Mastalier Bogdan 
Published: October 2024

IntroductionColorectal cancer stands as a predominant cause of cancer-related mortality worldwide. Despite progressive strides in surgical methodologies, the specter of postoperative complications is very large, significantly impacting both morbidity and mortality rates. This review aims to meticulously examine existing scholarly works to gauge the prevalence, severity, and therapeutic approaches to postoperative complications arising from colorectal cancer surgeries.MethodsEmploying a systematic approach, this study reviewed 135 peer-reviewed publications from the period of 2000–2023. The corpus was organized into categories reflective of the postoperative complications discussed: anastomotic leakage, port-site metastases, small bowel adhesions and obstructions, thrombosis, ileus, postoperative infections, urinary dysfunctions, and cardiovascular dysfunctions. Advanced artificial intelligence tools were leveraged for in-depth literature searches and semantic analyses to pinpoint research lacunae.ResultsThe analysis revealed that anastomotic leakage and postoperative infections garnered the majority of academic focus, representing 35% and 25% of the studies, respectively. Conversely, port-site metastases and cardiovascular dysfunctions were less frequently examined, accounting for merely 5% and 3% of the literature. The reviewed studies indicate a disparity in the reported prevalence rates of each complication, oscillating between 3% and 20%. Furthermore, the review identified a dearth of evidence-based management protocols, underscored by a pronounced heterogeneity in treatment guidelines.ConclusionsThe literature is replete with analyses on anastomotic leakage and postoperative infections; however, there exists a glaring scarcity of exhaustive research on other postoperative complications. This review emphasizes the pressing need for uniform treatment guidelines and spotlights areas in dire need of further research, aiming at the comprehensive enhancement of patient outcomes following colorectal cancer surgery.
Changes of vitamin D, Th17/Treg related cytokines and their correlations with disease activity in chronic spontaneous urticaria
Authors: Qiu Yangyang , Qiu Xiaoyan , Chen Yuting , Chen Meiqing , Huang Ling , Lin Xinyu , Wei Yi , Yang Ji , Gao Lujuan 
Published: October 2024

AimsTo investigate levels of 25-hydroxyvitamin-D (25HVD), interleukin-17 (IL-17), IL-27, IL-35, and transforming growth factor β1 (TGF-β1) in chronic spontaneous urticaria (CSU) patients and their correlations with disease activity.MethodsAn observational, case-control study was conducted. Eighty-one CSU patients and fifty-eight healthy individuals were recruited into two groups. Serum levels of 25HVD, IL-17, IL-27, IL-35, TGF-β1 were determined via enzyme-linked immunosorbent assay (ELISA). Disease activity of CSU was assessed using urticaria activity score (UAS).ResultsSerum level of 25HVD was significantly lower in CSU group compared to control group (P &lt; 0.001). Serum levels of IL-17 (P &lt; 0.001), IL-27 (P &lt; 0.001), TGF-β1 (P = 0.01) were significantly higher in CSU group than those in control group. In CSU group, the level of 25HVD was negatively associated with IgE (P &lt; 0.01) and positively correlated with IL-35 (P &lt; 0.01). In addition, serum level of IL-17 was negatively correlated with disease activity among female patients (P &lt; 0.05).ConclusionDeficiency of 25HVD is associated with development of CSU, the underlying mechanism might be related with IL-35. Likewise, IL-17, IL-27, IL-35, and TGF-β1 might also contribute to development of CSU.
Stem Longitudinal Gradient for Basic Density, Carbon, Nitrogen, and CN Ratio in Khaya spp.: Improved Correlation Using Diameter Instead of Commercial Height
Authors: Momolli Dione Richer , Caldeira Marcos Vinicius Winckler , Gomes Gabriel Soares Lopes , Gomes Robert , Duarte Victor Braga Rodrigues , Godinho Tiago de Oliveira , da Silva João Gabriel Missia , dos Santos Vaniele Bento , Vidaurre Graziela Baptista , Faria Júlio Cézar Tannure , Schumacher Mauro Valdir , Pereira Marcos Gervasio 
Published: October 2024

The basic wood density influences the carbon stock, playing a crucial role in climate-changing global mitigation through carbon sequestration. Understanding wood carbon release depends on the Nitrogen assessment and CN ratio. Therefore, our research aimed to: (i) Compare basic density, organic carbon, nitrogen, and C/N ratio among the Khaya grandifoliola, K. ivorensis, and K. senegalensis; (2) Analyze the gradient along positions and diameter of the commercial stem; (3) Recommend the most representative sampling position for each species based on the diameter. The experimental area is located in Southeastern Brazil. Twelve average-diameter trees per species were cut down, and wood disc samples were collected at 0, 25, 50, 75, and 100% commercial height. Our results show statistical differences in wood basic density among the species, and K. senegalensis has the highest basic density, 592 kg m3. There was no statistical difference in organic carbon between species and along the stem. Stem diameter instead of commercial height improved the variable studied, confirming the research hypothesis. Sampling at 17% of the commercial height, ranging to 18–22 cm stem diameters, is recommended for greater representativeness.
Identifying Calmodulin and Calmodulin-like Protein Members in Canavalia rosea and Exploring Their Potential Roles in Abiotic Stress Tolerance
Authors: Ding Qianqian , Huang Zengwang , Wang Zhengfeng , Jian Shuguang , Zhang Mei 
Published: October 2024

Calmodulins (CaMs) and calmodulin-like proteins (CMLs) belong to families of calcium-sensors that act as calcium ion (Ca2+) signal-decoding proteins and regulate downstream target proteins. As a tropical halophyte, Canavalia rosea shows great resistance to multiple abiotic stresses, including high salinity/alkalinity, extreme drought, heat, and intense sunlight. However, investigations of calcium ion signal transduction involved in the stress responses of C. rosea are limited. The CaM and CML gene families have been identified and characterized in many other plant species. Nevertheless, there is limited available information about these genes in C. rosea. In this study, a bioinformatic analysis, including the gene structures, conserved protein domains, phylogenetic relationships, chromosome distribution, and gene synteny, was comprehensively performed to identify and characterize CrCaMs and CrCMLs. A spatio-temporal expression assay in different organs and environmental conditions was then conducted using the RNA sequencing technique. Additionally, several CrCaM and CrCML members were then cloned and functionally characterized using the yeast heterogeneous expression system, and some of them were found to change the tolerance of yeast to heat, salt, alkalinity, and high osmotic stresses. The results of this study provide a foundation for understanding the possible roles of the CrCaM and CrCML genes, especially for halophyte C. rosea’s natural ecological adaptability for its native habitats. This study also provides a theoretical basis for further study of the physiological and biochemical functions of plant CaMs and CMLs that are involved in tolerance to multiple abiotic stresses.
ОСОБЕННОСТИ ФУНКЦИИ ЩИТОВИДНОЙ ЖЕЛЕЗЫ ВО ВРЕМЯ БЕРЕМЕННОСТИ: ОБЗОР ЛИТЕРАТУРЫ
Authors: Л.З. Аликенова , М.Ж. Еспенбетова , К.Ш. Амренова , С.Б. Амангельдинова 
Published: October 2024

В обзоре обсуждается функциональные особенности щитовидной железы, в процессе физиологически протекающей беременности, в частности в отдельные ее сроки. Влияние йодной недостаточности и радиоактивных эффектов на функциональное состояние щитовидной железы у беременных женщин. Влияние патологии щитовидной железы на беременность, плод и саму беременную женщину. Так же обсуждаются методы коррекции различных патологических изменений функции щитовидной железы в период гестации, так как они могут привести к невынашиванию беременности и патологии плода и новорожденного. Профилактические мероприятия для женщин, проживающих в регионе йодного дефицита на этапе планирования беременности, а так же индивидуальная йодная профилактика во время всей беременности и в периоде грудного вскармливания.
This review contains discusses of functional properties of the thyroid gland during the physiological pregnancy, particularly during in its different periods. Influence of iodine insufficiency and radioactive effects on the functional status of the pregnant women’s thyroid gland. Influence of the pathology of the thyroid gland on pregnancy, a fetus and a pregnant woman. Also, methods of correction of various pathological changes of functions of the thyroid gland during the gestation are discussed, as they can lead tohabitual miscarriage and to the pathology of the newborn. Preventive measures for the women living in the region of iodine deficiency at the pregnancy planning stage and individual iodine prevention, during the all pregnancy period and in the breastfeeding period.
Шолуда физиологиялық ағымдағы жүктілік процессінде, атап айтқанда оның жеке айы–күнінде қалқанша бездің функционалдық ерекшеліктері талқыланады. Жүкті әйелдер-дегі қалқанша бездің функционалды жағдай-ына йодты жетіспеушіліктің және радио-белсенді әсерлердің ықпалы. Жүктілікке, ұрыққа және жүкті әйелдің өзіне қалқанша без патологиясының әсері. Сол сияқты гестация кезіндегі қалқанша без қызметтерінің әртүрлі патологиялық өзгерістерін түзету әдістері талқыланады, өйткені олар жүктілікті аяғына дейін көтермеуге және ұрықтың және нәрестенің патологиясына әкелуі мүмкін. Йод жетіспеушілігі аумағында тұратын әйелдер үшін жүктілікті жоспарлау кезеңінде алдын алу іс–шаралары, сол сияқты барлық жүктілік кезінде және емізу мерзімінде жеке йодтық алдын алу.
ИНТРААБДОМИНАЛЬНАЯ ГИПЕРТЕНЗИЯ И КОМПАРТМЕНТ-СИНДРОМ: ОБЗОР ЛИТЕРАТУРЫ
Authors: Д.Н. Матюшко , Е.М. Тургунов , А. Злотник 
Published: October 2024

В статье представлен обзор литературы, посвященный интраабдоминальной гипертензии и компартмент-синдрому. На основании анализа современных книг, изданий, публикаций, мнений отечественных и зарубежных учёных в статье поднимаются такие до настоящего времени спорные вопросы в этой области, как: величина внутрибрюшного давления, способы и устройства измерения внутрибрюшного давления, теоретические и практические «границы» между интраабдоминальной гипертензией и компартмент-синдромом, а также причины развития, классификация, патофизиологические механизмы, клиническая картина, лечение и профилактика этих двух состояний
The article presents a review of literature devoted to the intraabdominal hypertension and compartment syndrome. Based on the analysis of current books, publications, the views of domestic and foreign scientists in the article authors raises such controversial issues in this area now, as: value of intraabdominal pressure, methods and devices of measurement of intraabdominal pressure, theoretical and practical "border" between the intraabdominal hypertension and compartment syndrome, and also the reasons of development, classification, pathophysiology, clinic, treatment and prevention of these two pathosis.
Мақалада интраабдоминалдықгипертензия жәнекомпартмент-синдромынаарналған әдебиеттер ұсынылған. Қазіргікітаптардың, басылымдардың, жарияланымдардың анализдары бойынша отандық және шетелдік ғалымдарының ой-пікірлері осы күнге дейін даулы сұрақтары болып табылады, олар: ішек қуыс қысым мөлшері, ішек қуыс қысымының өлшеуші құрылымы және әдісі, интраабдоминалды қысым және компартмент-синдром арасындағы теориялық және тәжірибелік «шекара», сондай-ақ осы екі күйінің даму себептері, классификациясы, патофизиологиялық тетіктері, клиникалық суреттері, емі және профилактикасы.
ДЕНСАУЛЫҚ САҚТАУ ЖҮЙЕСIН ҚАЙТА ҚҰРУ ЖӘНЕ ОНЫ ЖЕТIЛДIРУ ЖОЛДАРЫ ЖАҒДАЙЫНДА АЛҒАШҚЫ МЕДИЦИНАЛЫҚ-САНИТАРЛЫҚ КӨМЕК МЕКЕМЕЛЕРІНДЕ АЛДЫН АЛУ ЖҰМЫСТАРЫН ҰЙЫМДАСТЫРУ: ӘДЕБИЕТТЕРДІ ШОЛУ
Authors: И.Н. Ордабаева , Ф.С. Рахимжанова , Н.М. Рахимжанов 
Published: October 2024

Бұл мақалада дансаулық сақтау саласындағы өткен ғасырдың 20-шы жылдарынан бастап алдын алу жұмыстарының ұйымдастырылуының ерекшелігі мен жетілдірілуіне арналған әдебиетке шолу жазылған.
The paper provided an overview of the literary features and improving the organization of preventive work with the 20 years of the last century in the health sector.
В статье предоставлен литературный обзор особенности и совершенствования организаций профилактической работы с 20-х лет прошлого века в сфере здравоохранения.
ПОПЕРЕЧНЫЕ (ОДНОМОМЕНТНЫЕ) ИССЛЕДОВАНИЯ В ЗДРАВООХРАНЕНИИ
Authors: А.М. Гржибовский , С.В. Иванов 
Published: October 2024

В настоящей работе представлены основные принципы планирования, проведения и статистической обработки данных поперечных (одномоментных) исследований в здравоохранении. Приведены практические примеры расчета размера выборки и оценки связи между факторами риска с помощью онлайн-калькуляторов и пакета для обработки эпидемиологических данных Epi Info. Авторы представляют практические примеры использования поперечных исследований в литературе, а также достоинства и недостатки данного типа исследований. Настоящая статья призвана дать общие сведения о поперечных исследованиях, и не заменяет прочтения специализированной литературы по клинической эпидемиологии.
In this paper we present basic principles of planning and carrying out cross-sectional studies in health sciences as well as analyzing the data collected in these studies. We present practical examples of sample size and effect measures calculation for cross-sectional studies using online calculators and Epi Info software. Examples of studies using cross-sectional design from international peer-reviewed literature are also presented. This article provides general introduction to cross-sectional studies and does not substitute specialized literature in clinical epidemiology.
Осы жұмыста денсаулық сақтаудағы көлденең (бірсәттік) мәліметтерді жоспарлау, өткізу және статистикалық өңдеудің негізгі принциптері көрсетілген. Epi Info эпидемиологиялық мәліметтерді өңдеу үшін онлайн-калькуляторлар мен пакет көмегімен қауіп факторлары арасындағы байланысты таңдау және бағалау мөлшері есебінің практикалық мысалдары келтірілген. Авторлар әдебиеттегі көлденең зерттеулерді пайдаланудың практикалық мысалдарын, сол сияқты осы зерттеу түрлері қасиеттері мен жетіспеушіліктерін келтіреді. Осы мақала көлденең зерттеулер туралы жалпы мәліметтер беруге бейімделген, және клиникалық эпидемиология бойынша мамандандырылған әдебиетті оқуды ауыстырмайды.
КОГОРТНЫЕ ИССЛЕДОВАНИЯ В ЗДРАВООХРАНЕНИИ
Authors: А.М. Гржибовский , С.В. Иванов 
Published: October 2024

В настоящей работе представлены основные принципы планирования, проведения и статистической обработки данных когортных исследований в здравоохранении. Приведены практические примеры расчета размера выборки и оценки связи между факторами риска с помощью онлайн-калькуляторов и пакета для обработки эпидемиологических данных Epi Info. Авторы представляют практические примеры использования когортных исследований в литературе, а также достоинства и недостатки данного типа исследований. Настоящая статья призвана дать общие сведения о когортных исследованиях, и не заменяет прочтения специализированной литературы по клинической эпидемиологии.
In this paper we present basic principles of planning and carrying out cohort studies in health sciences as well as analyzing the data collected in these studies. We present practical examples of sample size and effect measures calculation for cohort studies using online calculators and Epi Info software. Examples of studies using cohort design from international peer-reviewed literature are also presented. This article provides general introduction to cohort studies and does not substitute specialized literature in clinical epidemiology.
Осы жұмыста денсаулық сақтаудағы көлденең когорттық жоспарлау, өткізу және статистикалық өңдеудің негізгі принциптері көрсетілген. Epi Info эпидемиологиялық мәліметтерді өңдеу үшін онлайн-калькуляторлар мен пакет көмегімен қауіп факторлары арасындағы байланысты таңдау және бағалау мөлшері есебінің практикалық мысалдары келтірілген. Авторлар әдебиеттегі көлденең зерттеулерді пайдаланудың практикалық мысалдарын, сол сияқты осы зерттеу түрлері қасиеттері мен жетіспеушіліктерін келтіреді. Осы мақала көлденең зерттеулер туралы жалпы мәліметтер беруге бейімделген, және клиникалық эпидемиология бойынша мамандандырылған әдебиетті оқуды ауыстырмайды.