bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return to Sport After Coracoid Transfer in Athletes With Anterior Shoulder Instability: A Systematic Review
Authors: Glogovac Georgina , Schumaier Adam P. , Grawe Brian M. 
Published: July 2019

Context: Recurrent shoulder instability in young athletes can lead to a spectrum of soft tissue and bony lesions that can be bothersome and/or disabling. Coracoid transfer is a treatment option for athletes with recurrent instability. Objective: To report the rate of return to sport for athletes after coracoid transfer. Data Sources: An electronic search of the literature was performed using the PubMed (MEDLINE) and Cochrane Databases (1966-2018). Study Selection: Studies were included if they evaluated return to sport after treatment with coracoid transfer at a minimum 1-year follow-up. Study Design: Systematic review. Level of Evidence: Level 4. Data Extraction: Data were extracted by 2 authors and included study design, level of evidence, patient demographics (number, age, sex), procedure performed, duration of clinical follow-up, rate of return to sport, patient-reported outcome measures, reoperations, and complications. Results: Fourteen studies met the inclusion criteria. The rate of return to sport at any level ranged from 80% to 100% in all but 1 study (38%), and the rate of return to the previous level of play ranged from 56% to 95% in all but 1 study (16%). Patients returned to sport at an average of 3.2 to 8.1 months. The average patient-reported outcome scores ranged from 78% to 94% (Rowe), 223.6 to 534.3 (Western Ontario Shoulder Instability Index), and 75% to 90% (subjective shoulder value). The rate of postoperative dislocation ranged from 0% to 14%, and the reoperation rate ranged from 1.4% to 13%. Conclusion: There was a high early rate of return to sport in patients who underwent coracoid transfer for anterior shoulder instability, although patients did not reliably return to the same level of play. The procedure had very favorable outcomes for treatment of instability, with low rates of recurrent dislocation and reoperation.
Multidimensional investigation of chronic pain experience and physical functioning following hip fracture surgery: clinical implications
Authors: Campos Hércules Lázaro Moraes , Liebano Richard Eloin , Lima Camila Astolphi , Perracini Monica Rodrigues 
Published: July 2019

Introduction:Older adults experience significant chronic pain after hip fracture, resulting in decreased physical functioning. However, pain investigation in this population is mostly limited to self-reported pain intensity. Detailed pain assessment may identify intervention targets other than pain relief. The aim of this study is to investigate multiple dimensions of pain experience (intensity, sensory, affective, evaluative and miscellaneous dimensions) and to correlate them to lower limb functionality and limitations in daily living activities.Methods:We conducted a cross-sectional study of 50 older adults (77.1 ± 8.1 years old) who underwent hip fracture surgery in the past 4 months. We used the Numeric Rating Scale (NRS), the McGill Pain Questionnaire (MPQ) and an algometer to assess pain intensity, pain quality and pressure pain threshold, respectively. Lower limb functionality and limitation in basic (activities of daily living (ADL)) and instrumental activities of daily living (IADL) were assessed using the Short Physical Performance Battery (SPPB) and the Brazilian OARS Multidimensional Functional Assessment Questionnaire.Results:Participants described pain as brief, momentary and transient, especially during weight-bearing activities. Although the pain intensity measured by the NRS was reported as moderate to severe (7.5 ± 1.6 points), it was not correlated with physical functioning. However, we observed a moderate negative correlation between pressure pain threshold, ADL and IADL disability ( r = –0.41, p < 0.01). Among pain qualities, the sensory category was moderately negatively correlated to SPPB ( r = –0.41, p < 0.01), and the evaluative category was moderately correlated to ADL and IADL disability ( r = 0.43, p < 0.01).Conclusion:Pain can be present 4 months after hip fracture surgery, particularly during weight-bearing activities, and it is associated with poor lower limb functionality, as well as ADL and IADL disability. Older adults may benefit from pain assessments that go beyond pain intensity measurements after hip fracture, as this helps clinicians optimise pain management and overall functional recovery.
Hip Fractures: Relevant Anatomy, Classification, and Biomechanics of Fracture and Fixation
Authors: Lu Young , Uppal Harmeeth S. 
Published: July 2019

Introduction: Hip fractures represent an important health-care dilemma, costing the US$ billions annually. Hip fractures can diminish quality of life and significantly increase morbidity and mortality if not properly treated. Recent research has brought forth new information regarding treatment as well as information on emerging complications seen within the fixation constructs themselves. Significance: Understanding the pathoanatomy of hip fractures and the biomechanics of surgical fixation constructs is critical for successful treatment. In this article, we review the relevant anatomy and classification of femoral neck and intertrochanteric fractures. Furthermore, the biomechanics of hip fracture fixation strategies as well as implant-related complications are addressed. Results: Even though laboratory testing demonstrated that intramedullary nails have greater biomechanical stability, the clinical results between fixation constructs have been similar when the chosen implant (ie, sliding hip screw vs cephalomedullary nail) has been correctly applied to the specific fracture pattern. Recently, data have shown that when using cephalomedullary nails, there is potential for increased failure with cutout when using the helical blade versus the lag screw, with majority being the atypical “medial cutout.” Conclusion: The goal of surgical treatment of hip fractures is surgical treatment that allows for early mobilization and weight bearing. A full understanding of the anatomy and fracture characteristics will allow the surgeon to correctly apply the right implant to allow for uneventful healing. Surgeons need to be aware, however, of complications that can arise when using specific implants. Further research is ongoing to further determine the treatments that will allow optimal cost-effective care for the geriatric patient with hip fracture.
Increased SLAMF7high monocytes in myelofibrosis patients harboring JAK2V617F provide a therapeutic target of elotuzumab
Authors: Maekawa Takaaki , Kato Shoichiro , Kawamura Toshikuni , Takada Kohei , Sone Takehiro , Ogata Hiraku , Saito Keita , Izumi Takuya , Nagao Shigeki , Takano Kosuke , Okada Yosuke , Tachi Noriaki , Teramoto Masahiro , Horiuchi Toshikatsu , Hikota-Saga Reina , Endo-Umeda Kaori , Uno Shigeyuki , Osawa Yukiko , Kobayashi Ayako , Kobayashi Shinichi , Sato Ken , Hashimoto Michihiro , Suzu Shinya , Usuki Kensuke , Morishita Soji , Araki Marito , Makishima Makoto , Komatsu Norio , Kimura Fumihiko 
Published: July 2019

Abstract
Monocyte-derived fibrocytes recently garnered attention because the novel pathogenesis of myelofibrosis (MF), and suppression of fibrocyte differentiation by serum amyloid P remarkably improved MF. We previously revealed that human fibrocytes highly expressed signaling lymphocytic activation molecule F7 (SLAMF7) compared with macrophages and that SLAMF7high monocytes in the peripheral blood (PB) of MF patients were significantly elevated relative to those in healthy controls (HCs). In this study, we evaluated SLAMF7high monocyte percentage in the PB of HCs, myeloproliferative neoplasm (MPN) patients with MF, and MPN patients without MF by using a cross-sectional approach. We found that MPN patients with MF who harbored JAK2V617F had a significantly elevated SLAMF7high monocyte percentage, which correlated positively with the JAK2V617F allele burden. In addition, the serum concentration of interleukin-1ra (IL-1ra) was significantly correlated with the SLAMF7high monocyte percentage and JAK2V617F allele burden. These findings suggest that both SLAMF7high monocytes and IL-1ra could be useful noninvasive markers of MF onset. Furthermore, the JAK2V617F allele burden of SLAMF7high monocytes was significantly higher than that of SLAMF7low monocytes and could be a potential target of elotuzumab (Elo), an anti-SLAMF7 antibody used for treating multiple myeloma. Elo independently inhibited differentiation of fibrocytes derived not only from HCs but also from MF patients in vitro. Elo also ameliorated MF and splenomegaly induced by romiplostim administration in humanized NOG mice. In conclusion, an increase of SLAMF7high monocytes with higher JAK2V617F allele burden was associated with the onset of MF in MPN patients harboring JAK2V617F, and Elo could be a therapeutic agent for MPN patients with MF who harbor JAK2V617F.
Posttransplant cyclophosphamide vs antithymocyte globulin in HLA-mismatched unrelated donor transplantation
Authors: Battipaglia Giorgia , Labopin Myriam , Kröger Nicolaus , Vitek Antonin , Afanasyev Boris , Hilgendorf Inken , Schetelig Johannes , Ganser Arnold , Blaise Didier , Itälä-Remes Maija , Passweg Jakob R. , Bonifazi Francesca , Finke Jurgen , Ruggeri Annalisa , Nagler Arnon , Mohty Mohamad 
Published: July 2019

Abstract
The use of anti-thymocyte globulin (ATG) has represented the standard of care in graft-versus-host disease (GVHD) prophylaxis in patients undergoing a mismatched unrelated donor (MMUD) transplant. The safety and feasibility of posttransplant cyclophosphamide (PTCY) in this setting have been reported recently, but no study has compared the outcomes of PTCY vs ATG in 9/10 MMUD transplants. Using the registry data of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we performed a matched-pair analysis comparing those 2 strategies in a 9/10 MMUD setting. Ninety-three patients receiving PTCY were matched with 179 patients receiving ATG. A significantly lower incidence of severe acute GVHD was observed with PTCY compared with ATG. Recipients of the former also showed higher leukemia-free survival and GVHD/relapse-free survival (GRFS). When performing a subgroup analysis including patients receiving peripheral blood stem cells, being in complete remission, or receiving the same associated immunosuppressive agents, superiority of PTCY over ATG was confirmed. Similar to the haploidentical setting, use of PTCY is an effective anti-GVHD prophylaxis in the 9/10 MMUD transplant. Use of PTCY may also provide better outcomes in long-term disease control. These results need confirmation in large prospective randomized trials.
Clinical and biological features of PTPN2-deleted adult and pediatric T-cell acute lymphoblastic leukemia
Authors: Alcantara Marion , Simonin Mathieu , Lhermitte Ludovic , Touzart Aurore , Dourthe Marie Emilie , Latiri Mehdi , Grardel Nathalie , Cayuela Jean Michel , Chalandon Yves , Graux Carlos , Dombret Hervé , Ifrah Norbert , Petit Arnaud , Macintyre Elizabeth , Baruchel André , Boissel Nicolas , Asnafi Vahid 
Published: July 2019

Abstract
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) is a phosphatase known to be a tumor suppressor gene in T-cell acute lymphoblastic leukemia (T-ALL). Because the full clinicobiologic characteristics of PTPN2 loss remain poorly reported, we aimed to provide a comprehensive analysis of PTPN2 deletions within a cohort of 430 patients, including 216 adults and 214 children treated according to the GRAALL03/05 (#NCT00222027 and #NCT00327678) and the FRALLE2000 protocols, respectively. We used multiplex ligation-dependent probe amplification to identify an 8% incidence of PTPN2 deletion, which was comparable in adult (9%) and pediatric (6%) populations. PTPN2 deletions were significantly associated with an αβ lineage and TLX1 deregulation. Analysis of the mutational genotype of adult T-ALL revealed a positive correlation between PTPN2 deletions and gain-of-function alterations in the IL7R/JAK-STAT signaling pathway as well as PHF6 and WT1 mutations. Of note, PTPN2 and PTEN (phosphatase and tensin homolog) deletions were mutually exclusive. Regarding treatment response, PTPN2-deleted T-ALLs were associated with a higher glucocorticoid response and a trend for improved survival in children, but not in adults, with a 5-year cumulative incidence of relapse of 8% for PTPN2-deleted pediatric cases vs 26% (P = .177).
Safe injection awareness and practices among nursing staff in an Egyptian and a Saudi hospital
Authors: Anwar Manal M. , Mohamed Lotfy Alshimaa A. , Alrashidy Afaf A. 
Published: July 2019

AbstractBackgroundUnsafe injection practices are an occupational hazard among the nursing staff. Awareness of nurses’ staff members about safe injection practices may vary between different hospitals according to the policies adopted for staff training and systematic auditing.AimTo assess awareness and practice of safe injection among nursing staff in a Maternal and Child Hospital, Qassim Region, Saudi Arabia, and Beni-Suef University Hospital, Egypt.MethodsA cross-sectional study using a structured questionnaire. Observations included 500 injections (250 from each hospital) from October to December 2017.ResultsThe mean awareness total scores in both hospitals were 9.98 ± 1.76 and 11.12 ± 0.96 respectively with a significant difference among observed nurses (P = 0.001). The mean safe injection practice total score was 27.13 ± 3.11 and 27.39 ± 2.17. Past year safe injection training was received for 95% and 70% for observed Egyptian and Saudi group of nurses. The majority of nurses (98.8%) were aware of the importance of safe injection practices to minimize blood-borne diseases, and 95.2% of them were aware of the placement of sharps disposal box beside the place of injection procedure. Exposure to the past year needlestick injuries (NSIs) was higher among the observed Egyptian nurses (P = 0.001). Using appropriately stored and refilled disinfectants was done by 48.5% and 51.5% of the observed nurses. Needle separation from its syringe inside sharps disposal box and sharps disposal boxes near patient care areas were observed in 95.2% and 95.6% of both hospitals respectively.Conclusions and recommendationNurses of both hospitals have good awareness and practice of injection safety. This might be attributed to the adoption of appropriate training courses. There is a need for continuous training sessions and auditing for nursing staff to ensure safe injection practices.
Need to have more Biomedical Journals with Impact Factor and importance of Publication Audit
Authors: Jawaid Shaukat Ali 
Published: July 2019

doi: https://doi.org/10.12669/pjms.35.4.1300
How to cite this:Jawaid SA. Need to have more Biomedical Journals with Impact Factor and importance of Publication Audit. Pak J Med Sci. 2019;35(4):882-886. doi: https://doi.org/10.12669/pjms.35.4.1300
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Η λειτουργία της βιβλιοθήκης στο νηπιαγωγείο
Authors: Μπατσούτα (Maria Mpatsouta) Μαρία , Παπαγιαννίδου (Christina Papagiannidou) Χριστίνα , Δάντη (Athina Danti) Αθηνά 
Published: July 2019

Στο Πρόγραμμα Σπουδών της γλώσσας του νηπιαγωγείου δίνεται ιδιαίτερη έμφαση στο χώρο της βιβλιοθήκης ως κατεξοχήν διαμορφωμένο περιβάλλον γραπτού λόγου. Η οργάνωση της γωνιάς της βιβλιοθήκης στο νηπιαγωγείο και η λειτουργία της ως δανειστική εφαρμόστηκε σε 130 νηπιαγωγεία της 2ης Περιφέρειας Προσχολικής Αγωγής κατά το σχολικό έτος 2003-2004. Στο παρόν άρθρο αποτυπώνεται η δράση αυτών των νηπιαγωγείων όσον αφορά στη λειτουργία της βιβλιοθήκης. Τα αποτελέσματα φανερώνουν ότι η βιβλιοθήκη λειτούργησε ως περιβάλλον εγγραμματισμού, αλλά κι ως πολυλειτουργικό μέσο για την ανάπτυξη δεσμού αγάπης με το βιβλίο και φιλαναγνωσίας. Ποικίλες και πρωτότυπες δράσεις πραγματοποιήθηκαν και ενίσχυσαν την επαφή και εξοικείωση των παιδιών με το βιβλίο. Οι τεχνικές δυσκολίες και τα προβλήματα συνεργασίας κατά την εφαρμογή υποδεικνύουν την ανάγκη να λαμβάνεται υπόψη κατά το σχεδιασμό και την ανάπτυξη της δράσης το εξελικτικό στάδιο γραφής των παιδιών, η σύνθεση της ομάδας και το κοινωνικοπολιτισμικό κεφάλαιο που φέρει το παιδί με την είσοδο του στο σχολείο. Η συνεργασία με τους γονείς αναδείχτηκε κρίσιμη προϋπόθεση για την επιτυχή λειτουργία της δανειστικής βιβλιοθήκης. Τέλος, οι δυσκολίες που καταγράφηκαν εισηγούνται προβληματισμό και αναζήτηση διαφορετικών τρόπων διαχείρισης σε άλλη μελλοντική εφαρμογή.
Ομάδες Μικτής Ηλικίας: Προκαταρκτική προσέγγιση
Authors: Σιβροπούλου (Irini Sivropoulou) Ειρήνη , Ευαγγέλου (Dimitra Evagelou) Δήμητρα 
Published: July 2019

Οι ομάδες μικτής ηλικίας αποτελούνται από παιδιά με ετερογενείς ικανότητες και διαφορά ηλικίας μεγαλύτερη από ένα χρόνο. Αυτές οδηγούν τους εκπαιδευτικούς να μη χρησιμοποιούν μονοσήμαντα προγράμματα που να υποχρεώνουν όλα τα παιδιά σε μια δεδομένη στιγμή να ασχολούνται με την ίδια δραστηριότητα. Επειδή οι έρευνες δείχνουν ότι οι τάξεις μικτών ηλικιών είναι πιθανόν να στηρίζουν την κοινωνική ανάπτυξη, να εμπλουτίζουν τη συναισθηματική και να ενθαρρύνουν τη νοητική επιχειρήσαμε να διερευνήσουμε τις απόψεις των Ελλήνων δασκάλων και νηπιαγωγών για τη συγκεκριμένη παιδαγωγική στρατηγική. Η έρευνα αποτελείται ουσιαστικά από τρία αλληλοεπιδρώντα μέρη. Ξεκινά από τη θεωρητική συζήτηση αναφορικά με τις Ο.Μ.Η. ακολουθεί η διερεύνηση, μέσω ερωτηματολογίου, των απόψεων 320 δασκάλων και 320 νηπιαγωγών από τους νομούς Θεσσαλονίκης, Κιλκίς, Δράμας, Φλώρινας, Καστοριάς και Χαλκιδικής. Η έρευνα καταλήγει στην ερμηνευτική ανάλυση από την οποία συνάγεται ότι οι δάσκαλοι και οι νηπιαγωγοί γνωρίζουν ελάχιστα για τις Ο.Μ.Η.
AVALIAÇÃO DO USO DE MEDICAMENTOS POR PUÉRPERAS NO PÓS-PARTO NORMAL E CESÁREA EM RELAÇÃO AOS RISCOS SOBRE A LACTAÇÃO EM UM HOSPITAL DO RIO GRANDE DO NORTE, BRASIL
Authors: Beserra da Silva João , Mariz Batista Almária 
Published: July 2019

O objetivo deste estudo foi avaliar o perfil do uso de medicamentos por puérperas no pós-parto normal e por cesareana do Hospital Regional Dr Mariano Coelho, Currais Novos, RN, Brasil, em relação aos riscos na lactação. Trata-se de estudo observacional, descritivo, a partir de prescrições arquivadas de puérperas assistidas durante o ano de 2018. Os medicamentos foram avaliados quanto ao risco para o lactente, conforme base de dados Micromedex, Academia Americana de Pediatria, Sociedade Brasileira de Pediatria e Ministério da Saúde. Os medicamentos foram compilados por princípio ativo e classe farmacológica de acordo com o sistema Anatomical Therapeutic Chemical Code e, posteriormente, analisados por estatística descritiva. Participaram do estudo 101 puérperas, a maioria submetida a parto cesárea (61,39%), condição em que também houve predominância do número de medicamentos/prescrição (7,61%) por cada puérpera, de um total de 592 prescritos. A maioria dos medicamentos utilizados no hospital eram compatíveis com a amamentação ou apresentavam riscos mínimos aos lactentes; no entanto, diferentes fontes bibliográficas podem abordar classificações diferentes para segurança do uso de medicamentos durante amamentação. Assim, prescritores e demais profissionais de saúde envolvidos no processo de orientação das puérperas devem manter-se embasados em fontes seguras sobre o uso de medicamentos durante este período.
Basic Income Experiments in the Netherlands?
Authors: van der Veen Robert 
Published: July 2019

Abstract
To many in the Netherlands it seems that basic income’s time has come, following the wide appeal of several municipal experiments. These random-control trial designs study the effects on employment, social participation, health and well-being of exempting social assistance claimants from the duties of seeking work and participating in training activities under the workfare-oriented Participation Act. In some treatment groups, claimants also retain a larger percentage of earnings, thereby reducing the poverty trap. These two design features resemble an unconditional basic income. I situate the experiments in the wider context of basic income and discuss their theoretical background and policy orientation. Under existing legal strictures, the experimental designs are too limited to judge the effects of replacing the conditional scheme of social assistance by an unconditional one. Yet these experiments point the way for future trials which can compare the effectiveness of basic income-oriented versus workfare-oriented treatments.
Zoo Tourism: What Actually Is a Zoo?
Authors: Nekolný Lukáš , Fialová Dana 
Published: July 2019

AbstractZoos are one of the most visited tourist attractions worldwide - we should perceive them, therefore, not only as places where animals are kept, but also as places frequented by large numbers of people. This is why we talk of zoo tourism. However, there are different definitions of a zoo. This wide range of possible approaches to what actually the zoo is poses a major methodological problem for the research analysis as well as for the zoo management and related legislation. Zoos are historically and socially determined. We can talk not only about the evolution of zoos but also about the co-evolution of zoos alongside many types of zoos. Nowadays, there is no doubt that there is a large number of modern and naturalistic zoos oriented on conservation, but there are also many zoos designed as popular animal-based attractions where animals live in unsuitable conditions. The principal aim of this article is to introduce and discuss problematic approaches to what zoos are and to suggest a use of a wider zoo definition.
Camellia: A Rapid Development Framework for Finite Element Solvers
Authors: Roberts Nathan V. 
Published: July 2019

Abstract
The discontinuous Petrov–Galerkin (DPG) methodology of Demkowicz and Gopalakrishnan guarantees the optimality of the finite element solution in a user-controllable energy norm, and provides several features supporting adaptive schemes. The approach provides stability automatically; there is no need for carefully derived numerical fluxes (as in DG schemes) or for mesh-dependent stabilization terms (as in stabilized methods).
In this paper, we focus on features of Camellia that facilitate implementation of new DPG formulations; chief among these is a rich set of features in support of symbolic manipulation, which allow, e.g., bilinear formulations in the code to appear much as they would on paper. Many of these features are general in the sense that they can also be used in the implementation of other finite element formulations. In fact, because DPG’s requirements are essentially a superset of those of other finite element methods, Camellia provides built-in support for most common methods. We believe, however, that the combination of an essentially “hands-free” finite element methodology as found in DPG with the rapid development features of Camellia are particularly winsome, so we focus on use cases in this class.
In addition to the symbolic manipulation features mentioned above, Camellia offers support for one-irregular adaptive meshes in 1D, 2D, 3D, and space-time. It provides a geometric multigrid preconditioner particularly suited for DPG problems, and supports distributed parallel execution using MPI. For its load balancing and distributed data structures, Camellia relies on packages from the Trilinos project, which simplifies interfacing with other computational science packages. Camellia also allows loading of standard mesh formats through an interface with the MOAB package. Camellia includes support for static condensation to eliminate element-interior degrees of freedom locally, usually resulting in substantial reduction of the cost of the global problem.
We include a discussion of the variational formulations built into Camellia, with references to those formulations in the literature, as well as an MPI performance study.