bluuebunny/crossref_metadata_2025_split huggingface dataset:
Os labirintos da tese e o medo de tingir palavras:
Authors: Nogueira de Oliveira Fernandes Aleksandra , De Brito Fernandes Stenio , Menezes de Paiva Marlúcia 
Published: November 2024

Escrever é uma atividade complexa e desafiadora, pois são inúmeras as dificuldades entre o pesquisador e o que está sendo estudado. Para tanto, o objetivo do estudo é refletir sobre os desafios inerentes à escrita da tese de doutorado e o medo de redigir no universo da pós-graduação. O percurso teórico aqui empreendido para análise, seguiu os pressupostos de uma abordagem qualitativa. Nesse caminho, realizamos uma pesquisa bibliográfica e narrativa. As narrativas erigidas são de uma doutoranda de um Programa de Pós-Graduação em Educação de um Instituto Federal do Brasil. Como resultados, depreendemos que o ato da escrita na pós-graduação é sinuoso, porém possível. Ademais essas dificuldades se sobrelevam para as mulheres, que além das atividades acadêmicas, têm que dar conta da educação dos filhos, das atividades do lar e da vida profissional. O artigo foi organizado em duas seções, além dessas considerações iniciais e das sendas (in) conclusivas. Na primeira, apresentamos uma reflexão sobre a escrita acadêmica e os seus desafios, especialmente quando realizadas por pós-graduandos em formação. Na segunda seção, realizamos um exercício de introspecção-retrospecção sobre as experiências em torno do escrever de uma mulher, mãe, esposa, professora e doutoranda vinculada a um Programa de Pós-Graduação de um Instituto Federal de Educação do Brasil.
PAIXÃO DO AMOR ENUNCIADA EM FRAGMENTOS DE UM DISCURSO AMOROSO, DE ROLAND BARTHES
Authors: Brixner Silvana Regina Martins , Martins Geraldo Vicente 
Published: November 2024

A linguagem do sujeito amoroso é composta e enunciada por discursos, denominados como figuras por Barthes; estas, acionadas no imaginário do sujeito, evocam sentidos múltiplos de reconhecimento, de vivência experimentada. Nos Fragmentos, o sujeito amoroso é o sujeito apaixonado representado por várias vozes repercutidas em toda a obra, em ecos e ressonâncias plenos de paixão. Para a semiótica, em uma abordagem inicial, temos as paixões, vistas a partir da semântica narrativa, como efeitos de sentido de qualificações modais que transformam o sujeito de estado. Na organização das estruturas modais, o sujeito pode estar modalizado por um querer, um poder, um dever ou um saber, permitindo que o objeto desejado torne o sujeito desejoso. Além desses pontos, a fundamentação teórica utilizada para este trabalho baseia-se em estudos desenvolvidos na semiótica discursiva e seus desdobramentos referentes à enunciação. Nessa empreitada, analisaremos o nível discursivo, o qual situa uma narrativa no tempo e no espaço, e o narrativo, com os actantes (sujeitos, objetos, destinadores e destinatários da narrativa), que se tornam atores do discurso; do primeiro, abordaremos também os procedimentos sintáticos de temporalização, espacialização e actorialização e os semânticos de tematização e figurativização, focalizando os efeitos de sentido desse discurso da paixão.
Palavras-chave: discurso; enunciação; paixão.
Do Credit Ratings Reflect Private Information about SEC Investigations?
Authors: Bonsall Samuel B. , Donovan John B. , Holzman Eric R. , Wang Xue , Yang Daniel G. 
Published: November 2024

ABSTRACT
Despite private access to managers, issuer-paid credit rating agencies (CRAs) are often criticized for failing to promptly reflect material negative private information in their ratings and being ineffective corporate watchdogs. We utilize a novel dataset of private SEC investigations to examine the timeliness and informativeness of CRAs’ rating adjustments in response to material negative private information. Our evidence suggests that CRAs adjust ratings downward within a quarter following the opening of an SEC investigation. Moreover, these adjustments are over three times larger for those investigations that ultimately yield an enforcement action than for those that do not, suggesting that CRAs quickly form sophisticated expectations about the materiality of the private information. Additionally, rating downgrades during the investigations are more informative to the stock market than other rating downgrades. Overall, our evidence suggests that CRAs reduce information asymmetry in the capital markets by timely incorporating material private information in their ratings.
Data Availability: All data are available from the sources cited in the text.
JEL Classifications: D82; G24; G30; M40; M41.
OPTIMASI DAN VALIDASI METODE KLT-DENSITOMETRI FASE TERBALIK UNTUK ANALISIS OKSIBENZON DALAM LOSION TABIR SURYA
Authors: Andayani Regina , Andira Retno Permata , Armin Fithriani 
Published: November 2024

AbstractSunscreen is useful for protecting the skin against sun exposure. Oxybenzone is one of the active ingredients in sunscreen which can cause skin allergies, redness, dryness, and acne. This study aims to optimize and validate the reverse phase densitometry thin layer chromatography (TLC) method for the analysis of oxybenzone in sunscreen lotions. The TLC silica gel 60 RP-18 F254 was used as the stationary phase, the mobile phase was acetonitrile: aquabidest (18:3). The Rf values of oxybenzone in lotion A and B were 0.63. The resolution of oxybenzone in lotions A and B were 2.53 and 3.2, respectively. The correlation coefficient (r) of oxybenzone was 0.999 in the range of 50 – 250 μg/mL, the limit of detection was 16.37 μg/mL and the limit of quantitation was 49.39 μg/mL. The precision of lotions A and B was ≤ 2%. The % recovery of oxybenzone in lotion A and lotion B was 99.33-99.63%. The results showed that the levels of oxybenzone lotion A and B were 3.4% and 2.59% successively. The reverse phase TLC-Densitometry method is a valid method for the analysis of oxybenzone in sunscreen lotions.Keywords: Oxybenzone, sunscreen, validation, thin layer chromatography-densitometry, reversed-phase. OPTIMASI DAN VALIDASI METODE KLT-DENSITOMETRI FASE TERBALIK UNTUK ANALISIS OKSIBENZON DALAM LOSION TABIR SURYA Abstrak Tabir surya berguna untuk melindungi kulit dari paparan sinar matahari. Oxybenzone merupakan salah satu bahan aktif tabir surya yang dapat menyebabkan alergi kulit, kemerahan, kering dan berjerawat. Penelitian ini bertujuan untuk mengoptimalkan dan memvalidasi metode kromatografi lapis tipis (KLT) densitometri fase terbalik untuk analisis oksibenzon dalam lotion tabir surya. Silika gel TLC 60 RP-18 F254 digunakan sebagai fase diam, fase geraknya adalah asetonitril: akuabides (18:3). Nilai Rf oxybenzone pada lotion A dan B adalah 0,63. Resolusi oxybenzone pada lotion A dan B berturut-turut adalah 2,53 dan 3,2. Koefisien korelasi (r) oxybenzone adalah 0,999 dalam kisaran 50 – 250 μg/mL, batas deteksi adalah 16,37 μg/mL dan batas kuantitasi adalah 49,39 μg/mL. Nilai presisis lotion A dan lotion B adalah ≤ 2%. Persentase perolehan kembali oxybenzone pada lotion A dan lotion B adalah 99,33-99,63%. Hasil penelitian menunjukkan bahwa kadar oxybenzone lotion A dan B berturut-turut adalah 3,4% dan 2,59%. Metode TLC-Densitometry fase terbalik adalah metode yang valid untuk analisis oxybenzone dalam lotion tabir surya.Kata kunci: Oxybenzone, tabir surya, validasi, kromatografi lapis tipis-densitometri, fase terbalik.
Kirschner wire creates more microdamage than standard or acrylic drill bits in the rabbit (Oryctolagus cuniculi) femur
Authors: Massie Anna M. , Kapatkin Amy S. , Garcia Tanya C. , Marcellin-Little Denis J. , Guzman David Sanchez-Migallon , Chou Po-Yen , Stover Susan M. 
Published: November 2024

Abstract

OBJECTIVE
Histologically evaluate damage to rabbit femur after the creation of bicortical 1.5-mm-diameter holes using a standard surgical drill bit, an acrylic drill bit, and a Kirschner wire (K-wire).

METHODS
10 femora (5 pairs) from skeletally mature female intact New Zealand white rabbits were used. The bone diaphyses were divided into 4 locations, systematically undergoing each test (surgical drill bit, acrylic drill bit, K-wire, and intact control). Four pairs were drilled using a mechanical testing machine, and 1 pair was drilled by hand. Cross-sections of the bone were stained en bloc with basic fuchsin for undecalcified histological evaluation. Damaged bone was reported as a percentage of a standardized area and categorized by location (cis- or transcortex), drill contact (entrance or exit of the cortex), and total damage (both cortices).

RESULTS
The drilling method (hand vs mechanical testing machine) had no effect on histologic damage, so results were analyzed by combining all data. The K-wire demonstrated the greatest area of cracks/damage compared to both standard surgical and acrylic drill bits, whereas no difference in damage was noted between the 2 drill bits for all variables.

CONCLUSIONS
The K-wire and drill bits caused microdamage; K-wire drilling created more microdamage than drill bits.

CLINICAL RELEVANCE
The rabbit bone cortex is thin and brittle relative to dogs and cats, leading to failure during and after fracture fixation. The clinical failure of rabbit bone is at least partially caused by drill bits or K-wires causing microcracks.
Pelatihan Cleanlinnes, Health, Safety & Environmental Sustainability (CHSE) di Rumah Sakit Bhayangkara Tk. III Indramayu
Authors: Chandra Teddy , Riyadi Heru , Prabowo Susilo Dwi , Sosiadi Rohyan , Wibowo Sukarno 
Published: November 2024

Since early in 2020, the Covid-19 pandemic has arrive in our home land. Many people get infected by this virus. The goverment take a quick and responsive restrictive, preventive and currative policy to mitigate this disaster. The social life has change. So many people normal habits has to be adjusted to the situation. Many healthy protocol was applied by the goverment to eradicate this global pandemic desease. CHSE was one of the healthy life style promoted by the goverment c.q Ministry Of Tourism Creative Economy. CHSE was the protocol to implementing the cleanlinnes, health, safety environmental sustainability. the purpose of this CHSE training was to create a healthier and condusive condition for the people, so they can still do the activity during the pandemic situation. Sejak awal tahun 2020 Pandemi Covid-19 datang melanda tanah air. Banyak di antara masyarakat Indonesia yang terjangkit virus corona ini. Pemerintah bergerak cepat dalam upaya mitigasi bencana virus ini dengan mengeluarkan berbagai kebijakan publik yang bersifat restriktif, preventif dan kuratif agar penyebarannya dapat ditekan. Hal itu berdampak kepada kehidupan masyarakat Indonesia. Kebiasaan-kebiasaan normal yang seringkali masyarakat lakukan, kini telah berubah. Berbagai pembatasan-pembatasan dan juga protokol kesehatan diterapkan oleh pihak berwenang dalam upaya untuk menanggulangi wabah global ini. Diantara beberapa kampanye gaya hidup sehat yang digaungkan pemerintah itu, salah satunya adalah kampanye Cleanlinnes, Health, Safety Environmental Sustainability (CHSE) yang digalakkan oleh kementerian pariwisata ekonomi kreatif. CHSE adalah suatu protokol kesehatan yang menekankan kepada terjaganya kebersihan (cleanlinnes), upaya menjaga kesehatan (health), upaya menjaga keamanan (safety) dan juga upaya menjaga kelestarian lingkungan (environmental sustainability). Tujuan dari pelatihan CHSE adalah agar terwujud suatu keadaan yang kondusif dalam menjalankan aktifitas di tengah pandemi yang belum diketahui kapan akan berakhirnya.
Influence of Electrode Surface Area and Processing Time on Chemical Oxygen Demand (COD) and Total Suspended Solid (TSS) Reduction in Tofu Wastewater Using Electrocoagulation
Authors: Faizal Dani , Wirantika Anila , Damajanti Neni 
Published: November 2024

Electrocoagulation is a wastewater treatment process that uses electrochemical working principles to remove contaminants in solutions or wastewater. Where at the anode (negative current) metal ions are released into solution, while at the cathode (positive current) an electrochemical reaction occurs, namely the release of H2 (hydrogen) gas. Factors that influence the electrocoagulation process include electrode type, current strength, electrode cross-sectional area, process time, voltage, stirring, distance between electrodes, and acidity level (pH). The objective of this research is to investigate the effect of the surface area of the electrode and processing time on the COD and TSS of tofu wastewater. In this research, tofu industry liquid waste was processed using the electrocoagulation method using fixed variables including, Fe-Fe type electrodes, 4 electrodes, acidity level at 4, tofu liquid waste temperature at 25 ̊ C, distance between electrodes 2 cm, electrode thickness 2 mm, test sample of 4 liters and current strength of 13 V. The changing variables used are electrode cross-sectional area (70 cm² and 60 cm²) and processing time (30, 45, 60, 75, 90 minutes). In this study, the best conditions for reducing COD and TSS levels were obtained with a cross-sectional area of ​​70 cm² and a process time of 60 minutes for reducing COD levels and 30 minutes for reducing TSS levels. With a reduction in COD levels of 690.66 mg/L and a reduction in TSS levels of 181.25 mg/L. The results of reducing COD levels do not meet the tofu industry wastewater quality standard of 300 mg/L, and the results of reducing TSS levels meet the tofu industry wastewater quality standard of 200 mg/L.
IDENTIFIKASI AREA RAWAN KEBAKARAN LAHAN DI KECAMATAN MUARA KAMAN KABUPATEN KUTAI KARTANEGARA MENGGUNAKAN APLIKASI SISTIM INFORMASI GEOGRAFIS
Authors: Fauzi Fauzi 
Published: November 2024

Identifikasi area rawan kebakaran di Kecamatan Muara Kaman Kabupaten Kutai Kartanegara menggunakan aplikasi sistem informasi geografis. Penelitian ini bertujuan mendapatkan informasi yang jelas mengenai area memiliki tingkat potensi kemudahan terjadinya kebakaran selanjutnya dapat digunakan sebagai acuan langkah pengendalian kebakaran oleh pihak-pihak yang berkepentingan. Penelitian ini memperkenalkan parameter baru sebagai penentu tingkat kerawanan suatu wilayah berupa pengelolaan lahan yaitu lahan terlantar dan lahan terkelola sebagai faktor yang mempengaruhi kemudahan terjadinya kebakaran. Hasil identifikasi area rawan kebakaran lahan di Kecamatan Muara Kaman yaitu dengan tingkat kerawanan kebakaran Sangat Tinggi seluas 110,352 Ha, tingkat kerawanan Tinggi seluas 34.925 Ha, tingkat kerawanan Menengah seluas 19.282 Ha, dan area dengan tingkat kerawanan Rendah seluas 165.426 Ha. Pada lahan terkelola, luas area dengan tingkat kerawanan Rendah adalah 165.416 Ha, dan tidak ada area dengan tingkat kerawanan Menengah, Tinggi dan Sangat Tinggi, pada Lahan Terlantar, area dengan tingkat kerawanan Rendah seluas 9 Ha, area dengan tingkat kerawanan Menengah seluas 19.283, pada area dengan tingkat kerawanan Tinggi seluas 34.926 Ha, dan pada area dengan tingkat kerawanan Sangat Tinggi seluas 110.353 Ha.
The Arc of Dramatic Catharsis: When Push Comes to Shove, Purge and Release, and How to Measure Them
Authors: Lambropoulos Niki 
Published: November 2024

The emergence of global, even universal, narratives has fostered a rich dialogue among diverse cultural expressions, enabling stories to transcend borders and resonate with audiences worldwide for maximum impact. Aristotle’s Poetics[1] is widely regarded as the foundational text in creative storytelling, playing a vital role in transmitting culture, values, knowledge, and traditions while inspiring innovation and change. It encourages imagination, exploration, and experimentation, fostering a dynamic, organic space that cultivates originality and growth. The hero recontextualizes reality within this framework, ultimately achieving relief, assimilation, and catharsis. By overcoming escalating external and emotional obstacles and internal conflicts, the hero drives the plot; their decisions and actions lead to liberating realizations and deeper self-understanding. Thus, dramatic catharsis serves as both the cause and purpose of the hero’s journey, shaping an arc that charts a path toward psychological transformation and self-actualization. Given the limited research on how the arc of dramatic catharsis unfolds in storytelling, this article presents a meta-study, synthesizing the findings of previous research.
Hereditary alpha tryptasemia: elevated tryptase, female sex, thyroid disorders, and anaphylaxis
Authors: Puxkandl Viktoria , Aigner Stefan , Hoetzenecker Wolfram , Altrichter Sabine 
Published: November 2024

IntroductionThe clinical significance of elevated baseline serum tryptase (BST) in the absence of mast cell disorders or allergic reactions has long been unclear. Recently, a genetic variation of the TPSAB1 gene, which among others encodes for alpha tryptase, has been reported and named hereditary alpha tryptasemia (HaT). HaT has been linked to various manifestations, including severe allergic reactions. However, clinical studies are limited. In this study, we aimed to determine HaT prevalence and characterize its clinical manifestations in patients at a specialized allergy center.MethodsFrom January 2022 to December 2023, patients with elevated BST at least once were screened for HaT at the outpatient clinic. A control group included patients with a history of anaphylaxis undergoing specific Hymenoptera immunotherapy. TPSAB1 copy numbers, BST levels, and clinical parameters were assessed and analyzed.ResultsOf 47 patients with elevated BST (≥11.4 µg/L), 93% showed increased TPSAB1 copy numbers. Individuals diagnosed with HaT displayed a BST range between 12.3 and 28.4 µg/L, with 84.1% associated with TPSAB1 duplication and 15.9% with triplication. HaT predominated in women (86.4%) and was associated with thyroid disease (27.3%). Over half had a history of anaphylaxis (54.5%), which was mainly low-grade.DiscussionIn patients with elevated BST but no mastocytosis, the most likely cause of elevated BST was an increase in the copy number of the TPSAB1 gene. A heightened risk of anaphylaxis should be considered. Further research is needed to explore the predominance of women and the emerging link with thyroid disease.
Optimizing scaffold pore size for tissue engineering: insights across various tissue types
Authors: Mukasheva Fariza , Adilova Laura , Dyussenbinov Aibek , Yernaimanova Bota , Abilev Madi , Akilbekova Dana 
Published: November 2024

Scaffold porosity is a critical factor in replicating the complex in vivo microenvironment, directly influencing cellular interactions, migration, nutrient transfer, vascularization, and the formation of functional tissues. For optimal tissue formation, scaffold design must account for various parameters, including material composition, morphology, mechanical properties, and cellular compatibility. This review highlights the importance of interconnected porosity and pore size, emphasizing their impact on cellular behavior and tissue formation across several tissue engineering domains, such as skin, bone, cardiovascular, and lung tissues. Specific pore size ranges enhance scaffold functionality for different tissues: small pores (∼1–2 µm) aid epidermal cell attachment in skin regeneration, moderate pores (∼2–12 µm) support dermal migration, and larger pores (∼40–100 µm) facilitate vascular structures. For bone tissue engineering, multi-layered scaffolds with smaller pores (50–100 µm) foster cell attachment, while larger pores (200–400 µm) enhance nutrient diffusion and angiogenesis. Cardiovascular and lung tissues benefit from moderate pore sizes (∼25–60 µm) to balance cell integration and nutrient diffusion. By addressing critical design challenges and optimizing pore size distributions, this review provides insights into scaffold innovations, ultimately advancing tissue regeneration strategies.
Koala ocular disease grades are defined by chlamydial load changes and increases in Th2 immune responses
Authors: Phillips Samuel , Madden Danielle , Gillett Amber , Quigley Bonnie L. , Jelocnik Martina , Bommana Sankhya , O’Meally Denis , Timms Peter , Polkinghorne Adam 
Published: November 2024

IntroductionThis study employs bulk RNA sequencing, PCR, and ELISA assays to analyze the pathological factors affecting the outcomes of C. pecorum ocular infections in koalas. It investigates the immune responses and gene expression profiles associated with various stages of koala ocular chlamydiosis.MethodsA cohort of 114 koalas from Queensland, Australia were assessed, with 47% displaying clinical signs of ocular disease. Animals were classified into three cohorts: acute active disease (G1), chronic active disease (G2), and chronic inactive disease (G3), along with subclinical Chlamydia pecorum positive (H2) and healthy (H1) cohorts.ResultsAnalysis of clinical, microbiological, humoral immune and cellular immune biomarkers revealed varying chlamydial loads and anti-chlamydial IgG levels across disease grades, with a negative correlation observed between ocular chlamydial load and anti-chlamydial IgG. Koala ocular mucosa gene expression analysis from 27 koalas identified shared expression pathways across disease cohorts, with a significant upregulation of IFNγ expression and tryptophan metabolism in all disease stages.DiscussionThese findings help elucidate immune response dynamics and molecular pathways underlying koala ocular chlamydiosis, providing insights crucial for disease management strategies.
Causal links of human serum metabolites on the risk of prostate cancer: insights from genome-wide Mendelian randomization, single-cell RNA sequencing, and metabolic pathway analysis
Authors: Pan Renbing , Liu Jingwen , Xiao Mingjia , Sun Chuanyang , Zhu Jianyong , Wan Lijun , Xue Boxin 
Published: November 2024

BackgroundRecently, serum metabolites have shown potential in predicting survival outcomes and may be related to the pathogenesis of prostate cancer. Nevertheless, the precise impact concerning the genetic effect of metabolites on prostate cancer risk remains obscure. In this context, we conducted a Mendelian randomization (MR) study aiming to explore the causality between genetically determined metabolites and the risk of prostate cancer.MethodsWe conducted a two-sample MR analysis aiming to identify the underlying metabolites associated with prostate cancer. Exposure information was obtained from the largest metabolome-based genome-wide association (GWAS) data containing 7,824 Europeans. Genome-wide association analysis was utilized to detect instrumental variables (IVs) for metabolites. We applied the inverse-variance weighted (IVW) approach as the primary method, and to augment the reliability and robustness of our findings, additional analysis methods encompassing weighted median, MR-Egger, and leave-one-out analysis were utilized. MR-Egger intercept test was implemented to explore the pleiotropy. Cochran’s Q test was utilized to quantify the degree of heterogeneity. Additionally, we performed metabolic pathway analysis and single-cell RNA sequencing analysis.ResultsWe found that three serum metabolites were causally associated with prostate cancer after utilizing rigorous screening standards. Utilizing single nucleotide polymorphisms as IVs, a 1-SD increase in fructose was associated with 77% higher risk of prostate cancer (OR:1.77, 95%CI: 1.05-2.97, PIVW=0.031), a 1-SD increase in N1-methyl-3-pyridone-4-carboxamide was associated with 29% higher risk of prostate cancer (OR:1.29, 95%CI: 1.05-1.58, PIVW=0.017), and a 1-SD increase in 12-hydroxyeicosatetraenoate (12-HETE) was associated with 18% higher risk of prostate cancer (OR:1.18, 95%CI: 1.07-1.31, PIVW=0.0008). Metabolites that were causally linked to the risk of prostate cancer were mainly enriched in the valine, leucine and isoleucine biosynthesis pathway (P=0.026) and the nicotinate and nicotinamide metabolism pathway (P=0.048).ConclusionsOur MR analysis provided suggestive evidence supporting the causal relationships between three identified serum metabolites and prostate cancer, necessitating further investigation to elucidate the underlying mechanisms through which these blood metabolites and metabolic pathways may impact the initiation and progression of prostate cancer.