bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing sepsis-induced immunosuppression to predict positive blood cultures
Authors: Hernández-Jiménez Enrique , Plata-Menchaca Erika P. , Berbel Damaris , López de Egea Guillem , Dastis-Arias Macarena , García-Tejada Laura , Sbraga Fabrizio , Malchair Pierre , García Muñoz Nadia , Larrad Blasco Alejandra , Molina Ramírez Eva , Pérez Fernández Xose , Sabater Riera Joan , Ulsamer Arnau 
Published: November 2024

IntroductionBacteremia is a life-threatening condition that can progress to sepsis and septic shock, leading to significant mortality in the emergency department (ED). The standard diagnostic method, blood culture, is time-consuming and prone to false positives and false negatives. Although not widely accepted, several clinical and artificial intelligence-based algorithms have been recently developed to predict bacteremia. However, these strategies require further identification of new variables to improve their diagnostic accuracy. This study proposes a novel strategy to predict positive blood cultures by assessing sepsis-induced immunosuppression status through endotoxin tolerance assessment.MethodsOptimal assay conditions have been explored and tested in sepsis-suspected patients meeting the Sepsis-3 criteria. Blood samples were collected at ED admission, and endotoxin (lipopolysaccharide, LPS) challenge was performed to evaluate the innate immune response through cytokine profiling.ResultsClinical variables, immune cell population biomarkers, and cytokine levels (tumor necrosis factor [TNFα], IL-1β, IL-6, IL-8, and IL-10) were measured. Patients with positive blood cultures exhibited significantly lower TNFα production after LPS challenge than did those with negative blood cultures. The study also included a validation cohort to confirm that the response was consistent.DiscussionThe results of this study highlight the innate immune system immunosuppression state as a critical parameter for sepsis diagnosis. Notably, the present study identified a reduction in monocyte populations and specific cytokine profiles as potential predictive markers. This study showed that the LPS challenge can be used to effectively distinguish between patients with bloodstream infection leading to sepsis and those whose blood cultures are negative, providinga rapid and reliable diagnostic tool to predict positive blood cultures. The potential applicability of these findings could enhance clinical practice in terms of the accuracy and promptness of sepsis diagnosis in the ED, improving patient outcomes through timely and appropriate treatment.
Radiotherapy as a metastasis directed therapy for liver oligometastases - comparative analysis between CT-guided interstitial HDR brachytherapy and two SBRT modalities performed on double-layer and single layer LINACs
Authors: Bilski Mateusz , Peszyńska-Piorun Magdalena , Konat-Bąska Katarzyna , Brzozowska Agnieszka , Korab Katarzyna , Wojtyna Ewa , Janiak Przemysław , Ponikowska Julia , Sroka Sylwia , Cisek Paweł , Fijuth Jacek , Kuncman Łukasz 
Published: November 2024

IntroductionSurgical resection is gold standard for treatment of liver metastasis, locally ablative techniques including computer tomography (CT)-guided interstitial high-dose-rate (HDR) brachytherapy (CT-BRT) and stereotactic body radiotherapy (SBRT) have gained prominence as alternatives, offering comparable outcomes in selected patients. We aim to compare CT-BRT and SBRT - based on dosimetric analysis.Material and methodsPatients who underwent CT-BRT for oligometastatic, ≤4cm liver metastases between 2018 and 2024 were eligible. SBRT plans for Halcyon (SBRTh) and TrueBeam (SBRTtb) were prepared virtually. In the CT-BRT group CTV was equal to PTV, for SBRTh and SBRTtb planning, a 5 mm margin was applied to CTV to create PTV. Dose calculation was carried out with the TG-43 algorithm for CT-BRT and Anisotropic Analytical Algorithm for SBRTh and SBRTtb group. Descriptive statistics were used to compare the data. The Wilcoxon pairwise order test was utilized to compare dependent groups.ResultsCT-BRT resulted in a more favorable dose distribution within PTVs for Dmean, D50, and D90, while SBRT showed better results for D98 and V27.5Gy. No significant differences were observed for V25Gy between CT-BRT and SBRTtb, but SBRTh favored over CT-BRT. For OARs, CT-BRT plans showed better values for V5, V10, and V11.6Gy in the uninvolved liver volume. There were no significant differences in dose distribution for the duodenum, bowel, and heart. SBRT modalities performed better in the kidney. CT-BRT had improved dose distribution in the esophagus, great vessels, ribs, skin, spinal cord, and stomach compared to SBRT.ConclusionsCT-BRT could be a viable alternative to SBRT for certain patients with liver malignancies.
Factors affecting the wellbeing of mid-achieving university students: a case study from China
Authors: Zou Dandan , Lin Zitong , Chen Chen , Yu Huiying 
Published: November 2024

BackgroundThe study aims to investigate the wellbeing of mid-achieving university students on campus and the factors affecting it. Given that this group represents a large yet often overlooked portion of higher education, the study endeavors to analyze the specific factors affecting their wellbeing to provide insights to foster a more comprehensive and inclusive educational environment.MethodologyThe study adopted a qualitative research method. A total of 30 mid-achieving university students from different departments at Guizhou Medical University in China were interviewed in-depth. The interviews were conducted via the online WeChat platform from 1st March 2024 to 13th September 2024. The semi-structured interviews focused on “moments in campus life that make mid-achieving university students feel happy or joyful.” All interviews were audio-recorded and transcribed into text, which was thoroughly coded and analyzed by the researcher using NVIVO 12 software to comprehensively assess the multiple factors that affect the wellbeing of students.ResultsThe wellbeing of mid-achieving university students is affected by a combination of factors, including freedom and autonomy, social interactions, collective activities, campus environment and facilities, and academic achievement.ConclusionEnhancing the autonomy of mid-achieving university students can significantly improve their self-efficacy and overall wellbeing. While social interactions and collective activities provide emotional support, they also present interpersonal challenges. Sufficient recreational spaces and a diverse range of food options on campus can help alleviate students’ stress and increase their satisfaction with campus services. Conversely, policies banning motorized bicycles may negatively affect students’ sense of wellbeing. Theoretically, the study contributes to the literature on student wellbeing in higher education psychology, particularly by offering a deeper understanding of the large but often neglected group of mid-achieving students. Practically, the findings emphasize the importance of creating more supportive and responsive educational environments tailored to the needs of these students, thereby facilitating inclusive campus environments and fully harnessing the learning potential of mid-achieving students. The study also proposes specific improvement strategies, such as optimizing campus facilities, enhancing student autonomy, and bolstering social and academic support systems. These measures are expected to directly improve the daily experiences of mid-achieving students and enhance their overall wellbeing.
Effects of repetitive transcranial magnetic stimulation on inhibitory control in first-episode schizophrenia: behavioral and neural mechanisms
Authors: Yu Sihang , Wang Shuai , Sun Hang 
Published: November 2024

BackgroundInhibitory control deficits are a core feature of cognitive impairment in schizophrenia, associated with abnormal activation of key brain networks. Repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex (DLPFC) may help improve inhibitory control, but its specific effects in schizophrenia remain uncertain.MethodsThis study involved 150 participants divided into Real-rTMS, Sham-rTMS, and healthy control groups. Inhibitory control was assessed using the dual-choice oddball task, and task-based functional magnetic resonance imaging (fMRI) was employed to examine neural activity. The Real-rTMS group received active stimulation over the DLPFC, and the Sham group received placebo stimulation.ResultsThe Real-rTMS group exhibited significant improvements in both reaction times and accuracy compared to the Sham group, indicating enhanced inhibitory control. fMRI data showed that brain activity in regions such as the cerebellum, insula, thalamus, and prefrontal cortex was normalized in the Real-rTMS group, with activation patterns closely resembling those observed in healthy controls. Additionally, task-based fMRI revealed a restoration and further enhancement of negative activation in regions like the middle frontal gyrus and superior temporal gyrus, which helped reduce cognitive interference from irrelevant stimuli.ConclusionrTMS targeting the DLPFC improves inhibitory control in schizophrenia by modulating both positive and negative brain activation patterns. These findings highlight the dual mechanism through which rTMS enhances cognitive control, offering a promising intervention for cognitive deficits in schizophrenia. Future research should explore the long-term effects of this modulation on broader cognitive functions.
Construction and application of the emergency resilience capability evaluation scale and model for grassroots medical workers: a cross-sectional study in Guangzhou, China
Authors: Wu Qiaohui , Wu Linjian , Liang Xueqing , Xu Jun , Liu Li , Huang Zhijie , Ma Zhen 
Published: November 2024

ObjectivePublic health emergencies pose a serious challenge to the ability of medical personnel to respond. We aimed to establish a scientific and effective resilience capability assessment scale for grassroots medical workers and explore the way to improve resilience.Research designDeveloped a resilience ability assessment scale and applied it on the medical personnel who worked in community health service centers for more than 1 year. Related indicators were identified through literature review and the Delphi method. The established scale was given weight using the attribute analytic hierarchy process, and the evaluation model was built through the grey correlation analysis.Principal findingsA three-level indicator scale was established, which included three first-level indicators [professional quality (weight 0.346), psychological capital (weight 0.614), and emergency attitude (weight 0.040)]. The second-level indicators had 13 contents and were further subdivided into 46 three-level indicators. The overall resilience ability assessment score of 347 medical workers in Guangzhou was only 0.787. However, steady scientific-exercise habits and relative training can help improve their public health emergency resilience ability (p &lt; 0.05).ConclusionThe establishment of the scale can provide a strategic basis for improving the resilience strength of grass-roots medical personnel. We should encourage this group to form a good habit of exercise, strengthen their crisis awareness by actively organizing theoretical training and practical exercises on public health emergencies, and improve their psychological capital level.Patient or public contributionIn this study, 347 medical workers from 6 basic medical institutions in Guangzhou participated in the questionnaire.
Exploring and enhancing the accessibility of children's oral health resources (called HABIT) for high risk communities
Authors: Chauhan Amrit , Staples Annalea , Forshaw Eleanor , Zoltie Timothy , Nasser Riffat , Gray-Burrows Kara A. , Day Peter F. 
Published: November 2024

BackgroundWithin the city of Bradford in West Yorkshire, South Asian and Eastern European communities have an increased risk of childhood tooth decay, especially among families with Limited English Proficiency. Tooth decay is preventable, with national guidelines advocating home-based behaviours (toothbrushing with fluoride toothpaste and reducing sugar intake). In England, Health Visitors have opportunities to undertake oral health conversations during universal visits for children aged 0–24 months. The HABIT (Health visitors delivering Advice in Britain on Infant Toothbrushing) intervention provides structured oral health conversations, underpinned by complex intervention methodology. A feasibility study found HABIT acceptable to parents, feasible to deliver and led to improvements in home-based behaviours. However, the reach of this original study was limited to those proficient in English. This new study focused on exploring and enhancing the accessibility of the HABIT intervention to parents with Limited English Proficiency.MethodTwenty-four parents participated in interviews and focus groups, with 21 requesting support from interpreters. Community centres and WhatsApp were used to maximise inclusivity. Interviews and focus groups, followed a topic guide and the “Think Aloud” technique, were professionally transcribed, managed in NVivo, and thematically analysed. Team discussions facilitated analytical rigour. Recruitment continued until data saturation.ResultsThree themes were developed: (1) Navigating linguistic barriers; (2) Engagement through visuals; and (3) Addressing oral health challenges. Parents employed diverse strategies to interpret resources, including Google Translate, as well as family and wider community members. Consequently, the HABIT resources were modified to include simple text, subtitles, and translation tools. Parents highlighted the benefits of shorter oral health messages with clear visuals to help understanding, and this strategy was applied across all resources. Challenges surrounding children's resistance to toothbrushing, high sugar intake within their wider families and communities, and limited dental access were all raised. The HABIT resources were updated to address these challenges.ConclusionCollaborative community engagement has enhanced the HABIT resources, enabling access for high-risk communities to preventive oral-health programmes thereby promoting health equity.
EFECTO BIOESTIMULANTE DE MENADIONA EN EL CONTROL DE Candidatus LIBERIBACTER SOLANACEARUM EN TOMATE
Authors: Roque-Enriquez Alberto , Ochoa-Fuentes Yisa M , Beltrán-Beache Mariana , Cerna-Chávez Ernesto , Delgado-Ortiz Juan C 
Published: November 2024

El tomate es una de las hortalizas de mayor consumo a nivel mundial, y México ocupa los primeros lugares en exportación. Plagas y enfermedades que atacan el cultivo de tomate obligan a los productores a usar plaguicidas, causando contaminación ambiental. En la actualidad se buscan nuevos productos que sean amigables con el medio ambiente, pero que a su vez tengan efectividad para el control de plagas y enfermedades; una opción viable es la menadiona bisulfito de sodio (MBS). El objetivo de la investigación fue determinar el efecto bioestimulante de la MBS en plantas de tomate infectadas con Candidatus Liberibacter solanacearum (CaLso), así como evaluar la incidencia y severidad de la enfermedad en las plantas. El experimento se desarrolló bajo condiciones de invernadero en tomate de la variedad Floradade, cuyas plantas se trataron con las concentraciones de MBS antes de la inoculación. Se establecieron ocho tratamientos, cuatro inoculados con CaLso y tratados con MBS (55, 80, 100 y 500 ppm), otro con tratamiento químico e inoculado, un tratamiento testigo inoculado y dos tratamientos sin inocular, uno como testigo absoluto y otro solo tratado con 500 ppm MBS. Enseguida se inoculó con CaLso y las aplicaciones de MBS fueron realizadas a intervalos de 15 días posteriores a la inoculación. Se evaluaron variables agronómicas, incidencia y severidad de la enfermedad. La MBS logró reducir la severidad de 23.5 a 41.7 % en plantas inoculadas con la bacteria CaLso, e incrementó las variables agronómicas de altura deplanta, peso fresco y peso seco de la planta y raíz, firmeza y grados Brix. Los resultados mostraron que la MBS puede ser integrada para el manejo de la enfermedad causada por CaLso en el cultivo del tomate.
Usia Menopouse Berhubungan dengan Penggunaan Kontrasepsi Hormonal di Desa Sei Tatas
Authors: Yusa Indah Wahyuni  , Cahyaningrum  
Published: November 2024

Hormonal contraceptives work by suppressing the function of the ovaries so that they do not produce ovum. Using hormonal contraception will cause women to enter menopause longer or older. One of the reasons for women who experience early menopause is due to the use of non-hormonal contraceptives. This study aims to determine the relationship between the use of hormonal family planning and menopause age in Sei Tatas Village.This type of research is an observational an correlational analytics alytic study with a cross sectional method. The population in this study were all elderly women aged 45-60 years with a total of 141 people, taking samples using the Acidental sampling technique with a sample size of 59 people. Methods of data collection using a questionnaire. Univariate analysis using frequency distribution and bivariate analysis using Chi Square test. 39 respondents (66.1%) using hormonal contraceptives and 20 nonhormonal users (33.9%). There were 17 people (28.8%) experiencing early menopause, 32 people (53.2 %) normal menopause and 10 people (16.9%) late menopause. The results of the chi square test analysis showed the P value = 0.036 < = 0.05. There is a relationship between the history of the use of hormonal contraception and the age of menopause in elderly women in Sei Tatas Village.

ABSTRAK
Kontrasepsi hormonal bekerja dengan menekan fungsi indung telur sehingga tidak memproduksi sel telur. Menggunakan kontrasepsi hormonal akan menyebabkan wanita lebih lama atau lebih tua memasuki usia menopause. Wanita yang mengalami menopause dini salah satunya disebakan karena penggunan kb non hormonal. Penelitian ini bertujuan untuk mengetahui hubungan penggunaan kb hormonal terhadap usia menopause di Desa Sei Tatas. Jenis penelitian ini adalah penelitian analitik korelasional dengan metode cross sectional. Populasi pada penelitian ini semua wanita lanjut usia 45-60 tahun yang ada di dengan jumlah 141 orang, pengambilan sampel menggunakan teknik Acidental sampling dengan besar sampel 59 orang. Metode pengumpulan data menggunakan kuesioner. Analisis univariat menggunakan distribusi frekuensi dan analisis bivariat menggunakan uji Chi Square. Didapatkan responden pengguna Kb hormonal sebanyak 39 orang (66.1%) dan non hormonal sebanyak 20 orang (33.9%). Terdapat 17 orang (28.8 %) mengalami menopause dini, 32 orang (53.2 %) menopause normal dan 10 orang (16.9%) menopause terlambat. Hasil analisis uji chi square menunjukkan nilai P value = 0.036 < α = 0.05. Adanya hubungan antara riwayat penggunaan kontrasepsi hormonal dengan usia menopause pada wanita usia lanjut di Desa Sei Tatas.
Dukungan Orang Tua dengan Interaksi Sosial pada Anak Retardasi Mental
Authors: Maura Fachriza Asral  , Fiki Wijayanti  
Published: November 2024

Parental support is important for the child's development process. Children with mental retardation really need parental support in terms of emotional support, instrumental, appreciation and informational support in helping children with mental retardation to interact socially with their environment. This study aims to determine the relationship between parental support and social interaction in mentally retarded children at SLB N Ungaran. This study used quantitative methods with a correlative research design using a crossectional approach. Samples were taken with total sampling technique with a total of 44 respondents. Data analysis in this study used kendall's tau b test. The results of research on 44 respondents Parental support obtained by 38 respondents (86.4%) good support and good social interaction with 36 respondents (81.8%) with p value (0.001) <0.05. This study has a correlation coefficient value of 0.509 which means that this study has a moderate relationship and leads to a positive relationship. Parental support obtained by 38 respondents (86.4%) good support and good social interaction with 36 respondents (81.8%). There is a relationship between parental support and social interaction of children with mental retardation in SLB N Ungaran. With this research, it is hoped that good parental support can be maintained or improved so that the social interaction of children with mental retardation is getting better
ABSTRAK
Dukungan Orang tua penting bagi proses perkembangan anak. Anak dengan retardasi mental sangat membutuhkan dukungan orang tua dari segi dukungan emosional, instrumental, penghargaan dan dukungan informasional dalam membantu anak dengan retardasi mental untuk berinteraksi sosial dengan lingkungannya. Penelitian ini bertujuan untuk mengetahui hubungan dukungan orang tua dengan interaksi sosial pada anak retardasi mental di SLB N Ungaran. Penelitian ini menggunakan metode kuantitatif dengan desain penelitian korelatif menggunakan pendekatan crossectional. Sampel diambil dengan tehnik total sampling dengan total 44 responden. Analisis data pada penelitian ini menggunakan uji kendall’s tau b. Hasil penelitian pada 44 responden didapatkan dukungan orang tua sebesar 38 responden (86,4%) dukungan baik dan interaksi sosial baik dengan 36 responden (81,8%) dengan p value (0,001) < 0,05. Penelitian ini memiliki nilai koefisien korelasi sebesar 0,509 yang memiliki makna bahwa penelitian ini memiliki hubungan cukup dan mengarah pada hubungan positif. Ada hubungan antara dukungan orang tua dengan interaksi sosial anak dengan retardasi mental di SLB N Ungaran. Dengan adanya penelitian ini diharapkan dukungan orang tua yang baik mampu dipertahankan atau ditingkatkan agar interaksi sosial anak dengan retardasi mental semakin baik