bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stomatal opening and growth in tomato seedlings treated with different proportions of red and blue light
Authors: Yang Junwei , Liang Tingting , Liu Lu , Pan Tonghua , Zou Zhirong 
Published: June 2019

Stomatal opening/closure plays a key role in balancing a plant’s need to conserve water, while still allowing for the exchange of photosynthetic and respiratory gasses with the atmosphere. Stomatal opening/closure can be induced by differences in light quality but a detailed knowledge of the role of light in stomatal regulation in tomato is limited. In this study, we evaluated red and blue light-dependent stomatal opening processes in tomato seedlings and explored the mechanisms involved using different light-quality treatments. After 10 h of darkness, tomato seedlings were subjected to the following five treatments: monochromatic red light (R), 33% blue (2R1B), 50% blue (1R1B), 67% blue (1R2B), and monochromatic blue light (B) at 200 μmol m−2s−1light intensity. The highest stomatal conductance recorded were for 1R1B. Stomatal aperture under 1R1B showed a 92.8% increase after 15 min and a 28.6% increase after 30 min compared with under R alone. Meanwhile, the study shows that the expressions of the plasma membrane H+-ATPase in the leaf were regulated by different proportions of blue light. The results show that the expressions of HA1 and HA4 increased under 1R1B and 1R2B after 15 min of exposure compared with under R alone. Under 1R1B, our results also show net photosynthesis increased compared with R and B after longer treatments, which may be related to chloroplast ultrastructure, and leaf dry weight increased compared with under 1R2B or B alone, but there were no differences under the R and 2R1B light treatments.
A case study in forensic soil examination from China
Authors: Guo Hongling , Wang Ping , Hu Can , Zhu Jun , Yang XueYing , Quan Yangke , Mei HongCheng , Li JinFeng 
Published: June 2019

Abstract
Soil examination can provide useful forensic information about the spatial location and human activities of a suspect. Soil is widely used in criminal investigations. In a case that occurred in the countryside of Jilin Province, in the NE of China, soil was found adhering to clothing on a body. Examination of plant debris in the soil using plant DNA barcoding technique found it to be ginseng root, which indicated that the soil might have come from a ginseng plantation. In the first instance, it helped in finding the place where the body was initially buried. Then a comparison was made between the soil recovered from the body and from the ginseng plantation. Composite analysis of minerals, pollen types and elements provided additional information to assist in making comparisons. Trace amounts of soil located on the body played an important role in locating the burial site and was regarded as the most valuable evidence in convicting the suspect of murder even without the suspect's DNA being available.
The forensic application of ground-penetrating radar, Tekoha Jevy indigenous village, Paraná, Brazil
Authors: Canata Rafael E. , Salvador Fábio A. S. , Borges Welitom R. , Ferreira Francisco J. F. , Seimetz Eduardo X. , Pinto Ivan , Barros Eduardo O. 
Published: June 2019

Abstract
Any archaeological site, according to the Brazilian Federal Constitution, is a patrimony of the Union; consequently, when crimes against this cultural patrimony occur, it becomes the responsibility of the Federal Police of Brazil. In 2013, there was a complaint to the Brazilian Federal Public Prosecutor's Office about the depredation of an archaeological site and forced withdrawal of the indigenous people because of the construction of a multimodal port in the city of Guaíra, in the state of Paraná, in southern Brazil. Thus, the Technical–Scientific Sector of the Federal Police Department, in partnership with Brazilian universities, used standard geophysical methods such as ground-penetrating radar (GPR) to investigate and locate buried archaeological targets. This paper discusses the results of 2D and 3D investigations in the Tekoha Jevy indigenous village, located in Guaíra County. In the field, 32 parallel sections of GPR data were acquired using 250 and 700 MHz shielded antennas. The results showed several anomalies, two of which were subjected to field checks using excavations, which revealed several artefacts such as ceramic fragments associated with ancient indigenous occupations on the banks of the Paraná River.
Temporal and spatial dynamics of spinal sensorimotor processing in an intersegmental cutaneous nociceptive reflex
Authors: White Jason M. , Lee Hyun Joon , Malone Patrick , DeWeerth Stephen P. , Tansey Keith E. 
Published: June 2019

The cutaneus trunci muscle (CTM) reflex produces a skin “shrug” in response to pinch on a rat’s back through a three-part neural circuit: 1) A-fiber and C-fiber afferents in segmental dorsal cutaneous nerves (DCNs) from lumbar to cervical levels, 2) ascending propriospinal interneurons, and 3) the CTM motoneuron pool located at the cervicothoracic junction. We recorded neurograms from a CTM nerve branch in response to electrical stimulation. The pulse trains were delivered at multiple DCNs (T6–L1), on both sides of the midline, at two stimulus strengths (0.5 or 5 mA, to activate Aδ fibers or Aδ and C fibers, respectively) and four stimulation frequencies (1, 2, 5, or 10 Hz) for 20 s. We quantified both the temporal dynamics (i.e., latency, sensitization, habituation, and frequency dependence) and the spatial dynamics (spinal level) of the reflex. The evoked responses were time-windowed into Early, Mid, Late, and Ongoing phases, of which the Mid phase, between the Early (Aδ fiber mediated) and Late (C fiber mediated) phases, has not been previously identified. All phases of the response varied with stimulus strength, frequency, history, and DCN level/side stimulated. In addition, we observed nociceptive characteristics like C fiber-mediated sensitization (wind-up) and habituation. Finally, the range of latencies in the ipsilateral responses were not very large rostrocaudally, suggesting a myelinated neural path within the ipsilateral spinal cord for at least the A fiber-mediated Early-phase response. Overall, these results demonstrate that the CTM reflex shares the temporal dynamics in other nociceptive reflexes and exhibits spatial (segmental and lateral) dynamics not seen in those reflexes.NEW & NOTEWORTHY We have physiologically studied an intersegmental reflex exploring detailed temporal, stimulus strength-based, stimulation history-dependent, lateral and segmental quantification of the reflex responses to cutaneous nociceptive stimulations. We found several physiological features in this reflex pathway, e.g., wind-up, latency changes, and somatotopic differences. These physiological observations allow us to understand how the anatomy of this reflex may be organized. We have also identified a new phase of this reflex, termed the “mid” response.
Contributions of optostatic and optokinetic cues to the perception of vertical
Authors: Niehof Nynke , Perdreau Florian , Koppen Mathieu , Medendorp W. Pieter 
Published: June 2019

While it has been well established that optostatic and optokinetic cues contribute to the perception of vertical, it is unclear how the brain processes their combined presence with the nonvisual vestibular cues. Using a psychometric approach, we examined the percept of vertical in human participants ( n = 17) with their body and head upright, presented with a visual frame tilted at one of eight orientations (between ±45°, steps of 11.25°) or no frame, surrounded by an optokinetic roll-stimulus (velocity =  ±30°/s or stationary). Both cues demonstrate relatively independent biases on vertical perception, with a sinusoidal modulation by frame orientation of ~4° and a general shift of ~1–2° in the rotation direction of the optic flow. Variability was unaffected by frame orientation but was higher with than without optokinetic rotation. An optimal-observer model in which vestibular, optostatic, and optokinetic cues provide independent sources to vertical perception was unable to explain these data. In contrast, a model in which the optokinetic signal biases the internal representation of gravity, which is then optimally integrated with the optostatic cue, provided a good account, at the individual participant level. We conclude that optostatic and optokinetic cues interact differently with vestibular cues in the neural computations for vertical perception. NEW & NOTEWORTHY Static and dynamic visual cues are known to bias the percept of vertical, but how they interact with vestibular cues remains to be established. Guided by an optimal-observer model, the present results suggest that optokinetic information is combined with vestibular information into a single, vestibular-optokinetic estimate, which is integrated with an optostatically derived estimate of vertical.
Repetitive doublet firing in human motoneurons: evidence for interaction between common synaptic drive and plateau potential in natural motor control
Authors: Kudina Lydia P. , Andreeva Regina E. 
Published: June 2019

The firing behavior of spinal motoneurons (MNs) is a result of processing synaptic inputs by MN membrane properties, including plateau potentials, fundamentally explored in animals. However, there is much less data about a plateau potential role in human motor control. We explored human MN repetitive doublet firing during gentle isometric voluntary muscle contractions with the aim of revealing possible evidence for interaction between plateau potentials and common synaptic drive known as an important determinant of MN pool firing behavior. Single-motor unit (MU) repetitive firing of trapezius and triceps brachii was analyzed. Subjects were asked to recruit MUs capable of firing repetitive doublets. The analysis of interspike intervals (ISIs) of background firing of simultaneously recorded MUs showed that beyond doublet series ISIs varied, often in unison with significant correlation coefficients, demonstrating common synaptic drive. During doublet series, MUs showed persistent doublet ISIs (typically 4–7 ms) and a tendency to increase the number of doublets in series throughout the experiment. This was consistent with involvement of MN plateau potentials resulting in persistent delayed depolarization (underlying each doublet) and warm-up effect. Common synaptic drive “started” doublet series; probably both mechanisms controlled postdoublet ISIs. However, convincing effects of plateau potentials on MU firing behavior during single firing were not found. Thus our results suggest a plateau potential role in specifying the essential firing pattern, doubling, of some MUs rather than its effect on firing behavior of the MN pool, on the whole, during voluntary muscle contractions in humans. NEW & NOTEWORTHY Properties of human motoneuron repetitive doublet firing were explored during voluntary muscle contractions. It was shown for the first time that these properties seem to be consistent with properties of both plateau potentials, resulting in persistent delayed depolarization (underlying each doublet) and common synaptic drive, starting this unusual firing; both mechanisms could probably control postdoublet intervals. A convincing effect of plateau potentials on motoneuron single-spike firing, despite doublet firing, was not found.
Six‐Year Incidence of Cardiometabolic Risk Factors in a Population‐Based Cohort of Chinese Adults Followed From 2009 to 2015
Authors: Wang Yiqing , Wang Huijun , Howard Annie Green , Adair Linda S. , Popkin Barry M. , Su Chang , Du Wenwen , Zhang Bing , Gordon‐Larsen Penny 
Published: June 2019

Background
China faces a substantial burden from cardiometabolic diseases, but longitudinal studies on a wide range of cardiometabolic risk factors are limited. We examined the 6‐year incidence of 8 cardiometabolic risk factors in a diverse, population‐based cohort.

Methods and Results

In the China Health and Nutrition Survey, anthropometry, blood pressure, and fasting blood samples were collected from 9621 adults (47.6% men) aged 18 to 99 years in 2009 who were followed into 2015. Using inverse probability weights to account for loss to follow‐up, we estimated the 6‐year incidence of 8 cardiometabolic risk factors and compared the incidence of each risk factor across age groups using inverse probability–weighted sex‐stratified logistic regression models. Incidence was noted for the following cardiometabolic risk factors during 2009–2015: hypertension (systolic/diastolic blood pressure ≥140/90 mm Hg; men: 29.2%; women: 24.9%), high waist circumference/height ratio (≥0.5; men: 42.4%; women: 43.8%), and high total to
HDL
(high‐density lipoprotein) cholesterol ratio (≥5; men: 17.0%; women: 14.5%). Older men and women (aged ≥65 years) had the highest incidence of hypertension. Incidence of high waist circumference/height ratio and high
LDL
(low‐density lipoprotein) cholesterol (≥130 mg/
dL
) was highest among older (aged ≥65 years) women, whereas incidence of overweight (body mass index ≥25) and high triglycerides (≥150 mg/
dL
) was highest among younger (aged 18–35 and 35–50 years) men.

Conclusions
We found increases in cardiometabolic risk among Chinese adults during this recent, short, 6‐year period that are higher than previous studies in China. The higher incidence of overweight and elevated dyslipidemia markers in younger versus older men portends an increasing burden of cardiometabolic diseases in China as the younger population ages.
Medical Treatment Failure for Symptomatic Vasospasm After Subarachnoid Hemorrhage Threatens Long-Term Outcome
Authors: Suwatcharangkoon Sureerat , De Marchis Gian Marco , Witsch Jens , Meyers Emma , Velazquez Angela , Falo Cristina , Schmidt J. Michael , Agarwal Sachin , Connolly E. Sander , Claassen Jan , Mayer Stephan A. 
Published: June 2019

Background and Purpose—
Symptomatic vasospasm is a common cause of morbidity and mortality after subarachnoid hemorrhage. We sought to identify predictors and the long-term impact of treatment failure with hypertensive therapy for symptomatic vasospasm.

Methods—
We performed a retrospective analysis of 1520 subarachnoid hemorrhage patients prospectively enrolled in the Columbia University SAH Outcomes Project between August 1996 and August 2012. One hundred ninety-eight symptomatic vasospasm patients were treated with vasopressors to raise arterial blood pressure, with and without volume expansion. Treatment response, defined as complete or near-complete resolution of the initial neurological deficit, was adjudicated in weekly meetings of the study team based on serial clinical examination after hypertensive treatment. Outcome was evaluated at 1 year with the modified Rankin Scale.

Results—

Twenty-one percent of the 198 patients who received hypertensive therapy did not respond to treatment. Treatment failure was associated with an increased risk of death or severe disability at 1 year (modified Rankin Scale score of 4–6; 62% versus 25%;
P
<0.001). Failure of medical therapy was also associated with an admission troponin I level >0.3 μg/L (64% versus 28%;
P
=0.001), aneurysm coiling (43% versus 20%;
P
=0.004), and involvement of >1 symptomatic vascular territory at onset (39% versus 22%;
P
=0.02). In multivariable analysis, treatment failure was independently associated only with troponin I elevation (adjusted odds ratio, 4.30; 95% CI, 1.69–11.09;
P
=0.002).

Conclusions—
Failure to respond to induced hypertension for symptomatic vasospasm threatens 1-year outcome. Subarachnoid hemorrhage patients with symptomatic vasospasm who have elevated initial troponin I levels, indicative of neurogenic cardiac injury, are at twice the risk of medical treatment failure. Expedited endovascular therapy should be considered in these patients.
Dosage Matters
Authors: Winstein Carolee , Kim Bokkyu , Kim Sujin , Martinez Clarisa , Schweighofer Nicolas 
Published: June 2019

Background and Purpose—
For stroke rehabilitation, task-specific training in animal models and human rehabilitation trials is considered important to modulate neuroplasticity, promote motor learning, and functional recovery. Little is known about what constitutes an effective dosage of therapy.

Methods—
This is a parallel group, 4 arms, single-blind, phase IIb, randomized controlled trial of 4 dosages of arm therapy delivered in an outpatient setting chronically after stroke. Participants were randomized into groups that varied in duration of scheduled therapy (ie, 0, 15, 30, or 60 hours). Forty-one participants completed the study. Planned primary analyses used linear mixed effects regression to model changes from baseline to postintervention in the Motor Activity Log-Quality of Movement rating and the Wolf Motor Function Test time score over 3 weeks of training as a function of therapy dosage.

Results—

We observed a dose response for the Motor Activity Log-Quality of Movement: the model that included dose and dose by week interaction significantly better fit the data than the model that included week only (log-likelihood test,
P
=0.0026). In addition, the greater the dosage of training, the greater the change in Motor Activity Log-Quality of Movement, with the dose by week interaction parameter equal to 0.0045 (
P
=0.0016; 95% CI, 0.0018–0.0071). Over the 3 weeks of therapy, there was a gain of 0.92 in Motor Activity Log-Quality of Movement for the 60-hour group compared to the 0-hour group. There was no dose response for the Wolf Motor Function Test.

Conclusions—
For mild-to-moderately impaired stroke survivors, the dosage of patient-centered, task-specific practice systematically influences the gain in quality of arm use but not functional capacity. We caution that we may have been underpowered for the functional capacity outcome. These findings highlight the importance of recovery outcomes that capture arm use in the natural environment.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01749358.
Interhospital Transfers for Endovascular Therapy for Acute Ischemic Stroke
Authors: Stein Laura K. , Tuhrim Stanley , Fifi Johanna , Mocco J. , Dhamoon Mandip S. 
Published: June 2019

Background and Purpose—
Multiple randomized clinical trials have demonstrated the superiority of endovascular therapy (ET) for large vessel occlusion acute ischemic stroke (AIS). Few centers can provide ET, and significant debate exists about the most efficient and effective ways to provide ET. We sought to assess real-world utilization of ET, the extent to which patients are transferred from one hospital to another for therapy and the implications of transfer status on outcomes.

Methods—

We used the 2015 to 2016 Healthcare Cost and Utilization Project Nationwide Readmissions Database, which contains nationwide data on nearly half of US admissions. We identified index AIS admissions, vascular risk factors, and treatment with intravenous thrombolysis and ET using
International Classification of Disease, Ninth Revision
, and
International Classification of Disease, Tenth Revision
Clinical Modification codes. Main predictors of outcome were treatment with ET and whether there was an interhospital transfer during the index AIS hospitalization. Among patients with AIS readmitted within 30 days, we examined 3 main outcomes: total charges, length of stay, and in-hospital mortality.

Results—
A total of 23 121 AIS admissions were treated with ET and 874 229 without. Over 5% of patients who received ET were transferred during the index admission compared with <2% of those not treated with ET. Length of stay and total charges were significantly higher in patients transferred (12.3 versus 9.6 days and $233 626 versus $182 881, respectively). More patients treated with ET who were not transferred to the index hospital were discharged home (25.3% versus 44.4%), and ≈25% of patients transferred for ET died during the hospitalization compared with 15.5% not transferred.

Conclusions—
The minority of all patients with AIS receive ET. The majority of patients who receive ET present directly to the center that performs the procedure, and those transferred for ET have higher length of stay, cost, and mortality that those not transferred.
Early Medieval Central Asian Population Estimates
Authors: de la Vaissière Étienne 
Published: June 2019

Abstract
Census data from 8th-century Eastern Central Asian oases, combined with the measurements of the oases and data from archives discovered there, allow us to calculate estimates both of the individual oases’ populations and of their respective feeding capacities, which is to say the number of people who could be fed from the output of one hectare of agricultural land. These numbers in turn have parallels in Western Central Asia, where oasis sizes can also be calculated by examination of preserved archaeological landscapes and oasis walls. It is therefore possible to reach a rough idea of the populations dwelling in the main oases and valleys of sedentary Central Asia. As regards nomadic regions, the data are far more hypothetical, but references in certain sources to the sizes of nomad armies and rates of nomadic military levying can allow us to calculate at least the possible scales of magnitude for populations living to the north of the Tianshan.
Babylonian Populations, Servility, and Cuneiform Records
Authors: Tenney Jonathan S. 
Published: June 2019

Abstract
To date, servility and servile systems in Babylonia have been explored with the traditional lexical approach of Assyriology. If one examines servility as an aggregate phenomenon, these subjects can be investigated on a much larger scale with quantitative approaches. Using servile populations as a point of departure, this paper applies both quantitative and qualitative methods to explore Babylonian population dynamics in general; especially morbidity, mortality, and ages at which Babylonians experienced important life events. As such, it can be added to the handful of publications that have sought basic demographic data in the cuneiform record, and therefore has value to those scholars who are also interested in migration and settlement. It suggests that the origins of servile systems in Babylonia can be explained with the Nieboer-Domar hypothesis, which proposes that large-scale systems of bondage will arise in regions with plentiful land but few workers. Once established, these systems persisted and were reinforced through Babylonia’s high balance mortality, political ideologies, economic incentives, and social structures.
Speaking the End Times: Early Modern Politics and Religion from Iberia to Central Asia
Authors: Green-Mercado Mayte 
Published: June 2019

Abstract
This introduction delineates the contours of early modern apocalyptic thought and practice among Christians, Muslims, and Jews by discussing specific themes explored in the five articles included in this special issue. It also situates the articles in the expansive scholarship on apocalypticism, highlighting the contribution of this collection of essays to the field. Paying close attention to and problematizing the importance of the terminology that expressed early modern notions of sacred history and political authority—in a context of intense inter-confessional contact and conflict—this introduction calls for a contextual examination of apocalyptic thought and practice.
Space, Sociality, and Sources of Pleasure: A Response to Sanjay Subrahmanyam
Authors: Kia Mana 
Published: June 2019

Abstract
This response essay engages with the themes of space, sociality, and sources (of pleasure and of scholarship) in Sanjay Subrahmanyam’s article in this issue, “The Hidden Face of Surat.” I reflect on how the Persianate adab that was a dominant cultural form in this port city might cause us to mitigate our analytical concepts when approaching phenomena from different historical contexts. I propose historical inquiry as a form of translation, to look for ways of understanding difference and engaging across it that may or may not be the same as European cosmopolitanism.