bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacological Approach of Pistacia Vera Fruit to Assess Learning and Memory Potential in Chemically-Induced Memory Impairment in Mice
Authors: Singh Satyam , Dharamveer  , Kulshreshtha Mayank 
Published: March 2019

Objective:
The present study was designed to investigate the potential of Pistacia vera
(P. vera) fruits in experimental memory impairments in mice.

Material & Methods:
Memory impairment was induced in Swiss Albino mice by scopolamine
(0.4mg mg/kg. i.p). Animals were divided into five separate groups of six animals each, positive control
group received carboxy methyl cellulose (CMC) as vehicle, negative control group received scopolamine
with vehicle, and standard group received donepezil (5mg/kg i.p) with Scopolamine. Ethanolic
extract of P. vera (EEPV) at doses of 200mg/kg & 400mg/kg p.o were administered to group
test1 & test 2 respectively along with scopolamine. Elevated plus maze (EPM), passive avoidance
paradigms and morris water maze (MWM) were used as exteroceptive behavioral models to access
learning and memory activity. Transfer latency, step down latency and escape latency parameters
were evaluated plus maze, passive avoidance paradigm, morris water maze. Thereafter lipid peroxidation
test, glutathione level and catalase activities were estimated in homogenized brain of mice.

Results:
Pretreatment of mice with EEPV (200mg/kg & 400mg/kg) significantly reduced scopolamine
induced amnesia. The obtained data clearly revealed that there was increase in escape latency in
MWM and also increase in step down latency in passive avoidance paradigm. Transfer latencey was
found to be decrease in EPM and biochemical. Parameters were clearly satisfied the data as compared
to negative control group which was indicative of cognitive improvement.

Conclusion:
P. vera fruit extract demonstrated to improve cognitive process by enhancing memory
in different experimental paradigm such as EPM, passive avoidance and MWM when administered
orally. Hence it would be worthwhile to explore the potential of this plant in the management of
memory disorders.
Informed Consent for Genetics Research in Italy
Authors: Fedeli Piergiorgio , Cannovo Nunzia , Guarino Rosa , Graziano Vincenzo 
Published: March 2019

Background:Genetic research has become an indispensable instrument for medical research, and the subjects involved have both divergent and convergent interests.Objective:The possibility of having more detailed genetic information undoubtedly offers benefits for the health of the subject, but could also pose risks and make the subject vulnerable to discrimination.The scientific community has viewed very favorably the public health utility of family history, in which data from a family whose members suffer from chronic pathologies is collected and filed, in order to develop a sort of "stratification of family risk."Even though in the last decade the scientific and juridical literature has contributed greatly to the topic of biobanks, the perplexities that continue to surround this theme give the idea that current ethical protocols on research are inadequate.Conclusion:Genetic data must be used not to exploit, but to serve the person. Freedom and responsibility must be the twin guiding lights for establishing parameters for the use of biological samples. An evaluation of how this technology impacts the various aspects of the future of society is urgently needed.
Three-dimensional palatal anatomic characteristics' correlation with dermatoglyphic heterogeneity in Angle malocclusions
Authors: AlShahrani Ibrahim , Dawasaz Ali A. , Syed Sadatullah , Ibrahim Mohammed , Togoo Rafi A. 
Published: March 2019

ABSTRACTObjectives:To assess correlation of dermatoglyphic (DG) pattern with quantitative palatal anatomic parameters measured using three-dimensional (3D) scanning of dental casts and to explore the possibility of utilizing these to predict future occurrence of malocclusion.Materials and Methods:Pretreatment casts of 477 Saudi Arabian patients were divided into Class I, II, and III malocclusion groups. Fingerprints were recorded for all hand digits using a digital biometric device. Maxillary arch analysis was accomplished including intercanine, intermolar distance, palatal height, and palatal area. The results were statistically analyzed.Results:The mean surface area of the palate was highest in Class II malocclusion. The DG pattern was not significantly associated with the type of malocclusion, except in the instance of the double loop characteristic (P = .05). There was a strong correlation, however, between DG characteristics like simple arch, loop, and double loop and palatal dimensions (intercanine, intermolar distance, and palatal height). Heterogeneity of DG pattern could be reliably used to predict palatal dimensions. Logistic regression revealed that only tented arch, symmetrical, spiral DG patterns and palatal area were significant but weak predictors of Angle malocclusion (P &lt; .05).Conclusions:A novel correlation of DG pattern with 3D palatal anatomic characteristics was assessed in different Angle malocclusion classes. Few of the DG characteristics and palatal dimensions showed significant correlations. However, only some of these were significant predictors of Angle malocclusion.
TRANSFORMASI DESAIN RUMAH TINGGAL DI PERUMAHAN PADMA RESIDENCE (BANTUL, YOGYAKARTA) SAAT DITEMPATI
Authors: Agnes Gabriella Calista 
Published: March 2019

Abstract: A house is a basic need for every human’s life. It is not only a place for shelter, but also a place for a family to live, to have social interaction between them, to raise the children, and to give the values of life. Padma Residence is a modern residence which is built by PT. Surya Coco Jaya. Most of its residents make changes to their houses after they occupy it. The main purpose of this study is to observe changes toward the initial design by comparing the initial design and present condition, recording the present condition of the house when it has occupied by determine architectural elements which are changed, determining causal factors of changes, and finding out dominant causal factors toward alteration of architectural elements of the house at Padma Residence, Bantul, Yogyakarta while it is occupied. Methods used in data collecting are literature study and a field survey. A field survey includes observation, interview, and distributing questionnaires to 25 respondents who are the owners of houses in this residence. Data analysis used table which compare the initial design and nowadays condition. The result of data processing and analyzing reveals that the owners do physical changes at their houses while they occupy them, particularly at the front appearance of the house. The changes include the addition of canopies at carport and changes in the layout of the rooms, such as kitchen, dining room, and backyard. A dominant factor which has caused those changes is the function of rooms which is added to the house.Keywords: residence, physical changes, the additon of functionAbstrak : Rumah merupakan kebutuhan utama bagi kehidupan setiap manusia. Selain sebagai tempat untuk berlindung, rumah juga merupakan wadah atau tempat manusia atau sebuah keluarga melangsungkan kehidupannya. Perumahan Padma Residence merupakan sebuah hunian modern yang dibangun PT. Surya Coco Jaya dan sebagian besar penghuninya melakukan perubahan pada rumah tinggalnya saat ditempati. Tujuan utama penelitian ini adalah mengetahui perubahan terhadap desain awal rumah tinggal dan kondisi rumah tinggal tersebut saat ditempati dengan mengetahui unsur-unsur arsitektural yang berubah pada desain rumah tinggal saat ditempati di Perumahan Padma Residence, Bantul, Yogyakarta. Metode penelitian dilakukan dengan studi literatur dan survei lapangan. Survei lapangan meliputi pengamatan, wawancara, dan penyebaran kuesioner kepada 25 responden yang merupakan pemilik rumah tinggal di perumahan tersebut. Hasil dari pengolahan dan analisis data menunjukkan bahwa pemilik rumah melakukan perubahan fisik pada rumah tinggalnya saat ditempati, terutama pada tampilan depan bangunan, perubahan yang dilakukan adalah menambahkan kanopi pada carport, peletakan ruang seperti dapur, ruang makan, dan taman belakang. Faktor-faktor yang menjadi penyebab perubahan tersebut adalah pertambahan fungsi ruang.Kata kunci: rumah tinggal, perubahan fisik, pertambahan fungsi
KONSEPSI LANGGAR SEBAGAI RUANG SAKRAL PADA TANEAN LANJANG
Authors: Heng Jeckhi , Kusuma Aji Bayu 
Published: March 2019

Abstract: Research on Langgar as a sacred place in Tanean Lanjang has done as its role in the settlement in Madura. This research aims to explore the role of Langgar in Tanean Lanjang. Methods used in data collecting are a field survey and studies of literature on the architecture of religious islamic buildings. The analysis focused on architectural form and traditional elements in Madura traditional settlement to get the conclusion on the comprehension of the role of Langgar in Tanean Lanjang. Langgar has an important meaning to people who are living in Madura as a center of activities for men in transferring religious values. It is also a place for living at noon and sleeping at night, a place for receiving guests, a place for daily praying, as well as a place to store the agricultural products. Langgar is a main sacred place in every settlement in Madura.Keywords: langgar, sacred place, Tanean LanjangAbstrak: Penelitian langgar sebagai ruang sakral pada Tanean Lanjang berawal dari fenomena keberadaannya di setiap rumah yang berada di Madura. Penelitian ini bertujuan agar peran Langgar terhadap Tanean Lanjang lebih dikenal. Metode yang digunakan pada penelitian ini adalah metode pengumpulan data melalui studi literatur mengenai arsitektur langgar atau masjid dan survei , metode analisis dengan fokus kajian pada bentuk arsitektur dan elemen tradisional permukiman Madura, dan metode menarik kesimpulan untuk memahami pentingnya pemaknaan langgar pada permukiman Tanean Lanjang. Langgar memiliki arti yang penting bagi masyarakat Madura. Langgar berfungsi sebagai pusat aktivitas laki-laki, yaitu transfer nilai religi, sebagai tempat bekerja pada siang hari, tempat menerima tamu, tempat istirahat dan tidur laki-laki, serta dipakai untuk melakukan ritual keseharian dan juga sebagai gudang hasil pertanian. Langgar menjadi ruang vital yang harus ada di setiap rumah, dalam sistem permukiman masyarakat Madura dan menjadi ruang sakral.Kata kunci: langgar, ruang sakral, Tanean Lanjang
DESAIN BERBASIS ERGONOMI; STUDI ERGONOMI PADA FASILITAS PENUNJANG PELAYANAN KEFARMASIAN; Studi Kasus Apotek di Jalan Jenderal Sudirman, Purworejo
Authors: Edo D Michael 
Published: March 2019

Abstract: Nowadays health becomes important, thats why many people even in health body still need medicine or vitamin to protect their body, especially today health body didn’t recognize time. Enterpreneur catch these business opportunity and realize it into a pharmac. An pharmacy in Jenderal Sudirman Street at Purworejo is one example of a response to the opportunity, thus providing a complete variety of types of drugs as well as 24-hour service. However, because of limited land availability, the shophouse became the answer. Shophouses transformed into a place of business that is cultivated good and comfortable. How the application of ergonomics of a pharmacy that located in a shophouse. Through the function conversion of the building, the availability, requirement and quality of the space and supporting things for pharmacy, should remain acommodated properly when used by users for 24 hours each day. This study reached by direvt observation and through inerviews with pharmacy employees as users of the space, so we can know the user needs with a proper ergonomics which adapted to its space.Keywords : Ergonomics, Pharmacy, Quality of Space, 24 HoursAbstrak: Kesehatan saat ini menjadi hal penting, sehingga banyak orang dalam keadaan sehat sekalipun tetap membutuhkan obat ataupun multivitamin guna menjaga stamina agar tetap sehat, terlebih lagi daya tahan tubuh mausia tidak mengenal waktu. Pengusaha menangkap peluang tersebut dan merealisasikannya ke dalam sebuah apotek. Apotek di Jalan Jenderal Sudirman, Purworejo merupakan salah satu contoh respon terhadap peluang baik tersebut, sehingga menyediakan ragam jenis obat yang lengkap serta pelayanan 24 jam. Namun, karena keterbatasan lahan yang ada, maka ruko menjadi jawabannya. Ruko disulap menjadi sebuah tempat usaha yang diusahakan baik dan nyaman. Bagaimana penerapan ergonomi sebuah apotek yang terletak di sebuah ruko. Melalui alih fungsi bangunan, ketersediaan dan kualitas ruang serta pendukung ruang apotek harus tetap terakomodasi dengan baik, saat digunakan oleh penggunanya selama 24 jam setiap harinya. Studi ini ditempuh dengan melakukan observasi langsung serta melalui wawancara dengan karyawan apotek selaku pelaku ruang, sehingga dapat diketahui kebutuhan ruang dengan ergonomi yang tepat dan sesuai dengan wadahnya.Kata Kunci : Ergonomi, Apotek, Kualitas Ruang, 24 Jam
STUDI ERGONOMI PADA AKSESIBILITAS DIFABLE PUSKESMAS DEPOK I SLEMAN; STUDI KASUS PUSKEMAS DEPOK I SLEMAN
Authors: Yunizar Dimas Kharisma 
Published: March 2019

Abstrak: Menurut rumusan Sistem Kesehatan Nasional (SKN), Puskesmas adalah salah satu bentuk pokok pelayanan kesehatan di Indonesia, dan merupakan salah satu bentuk pelayanan kesehatan yang tergolong primary health care. Pemikiran untuk meningkatkan kualitas hidup bagi kelompok masyarakat khususnya difabel (different ability) atau sering disebut dengan “orang yang memiliki kemampuan berbeda” didasarkan atas prinsip kesetaraan (persamaan) kesempatan dan partisipasi dalam berbagai aspek hidup dan kehidupan terutama yang berkenan dengan masalah aksesibilitas, rehabilitasi, kesempatan kerja, kesehatan serta pendidikan. Penelitian direncanakan pada Puskesmas Depok I Sleman. Lokasi penelitian difokuskan pada ruang-ruang yang digunakan oleh pasien setiap saat. Wawancara dilakukan secara langsung dengan pasien maupun karyawan yang bekerja di Puskesmas Depok I Sleman, untuk informasi-informasi berupa tanggapan dan permasalahan yang mereka rasakan selama berada di bangunan ini. kelengkapan data sekunder diperoleh dari bagian administrasi Puskesmas berupa profi l Puskesmas serta data yang berhubungan dengan penelitian. Mencari Literatur berupa jurnal, standar pergerakan manusia, standarluasan ruang, yang akan disesuaikan untuk mendapatkan ergonomi di dalam Puskesmas Depok I Sleman ini. Prinsip layanan fasilitas publik aksesibilitas difabel sebenarnya sangat sederhana, kata aksesibilitas mempunyai bahwa semua orang yang termasuk kaum difabel, tanpa bantuan siapa pun, dapat mencapai dan memasuki suatu lingkungan kawasan bangunan kemudian dapat menggunakan seluruh fasilitas di dalamnya tanpa merasa menjadi obyek belas kasihan orang lain.Kata kunci: Puskesmas, aksesibilitas, difable
PEMERIKSAAN KEABSAHAN PENETAPAN TERSANGKA OLEH PRAPERADILAN DALAM KONSTELASI PANCASILA
Authors: Anditya Ariesta Wibisono 
Published: March 2019

ABSTRACTIndonesian supremacy of law principle is the ground rule to control the democracy flow in society. In order to do so, Pretrial institution is introduced. Pretrial, under Constitution Court Session Number 21/PUU-XII/2014, also has a jurisdiction in examining suspect naming procedure by investigator. Despite being regulated, there was found in which judge made decision to name a suspect, whereas the provision instructed the judge to only take measure and examine suspect naming by investigator, therefore undermining given regulation. This conceptual research conducted under normative method. Historical, grammatical, concept and case approach also applied. The result demonstrates that evaluating suspect naming could support and undermine Pancasila simultaneously.Keywords : pretrial, Pancasila, suspect naming, democracy INTISARIPraperadilan hadir sebagai bentuk pengawas terhadap peran penyidik dan penuntut umum, dalam hal ini, berdasarkan putusan Mahkamah Konstitusi Nomor 21/PUU-XII/2014 menambahkan kewenangan salah satunya untuk menguji keabsahan penetapan tersangka. Wujud kontrol yang demikian ternyata tidak sepenuhnya diterapkan oleh hakim dengan baik. Peristiwa yang menjadi bukti luputnya penerapan pemeriksaan keabsahan tersangka salah satunya dimana hakim Praperadilan memerintahkan menetapkan tersangka, dengan demikian melampaui batas kewenangan. Metode penelitian yang dilakukan adalah normatif dengan pendekatan filosofis, gramatikal, konsep dan kasus. Hasil menunjukkan bahwa wewenang Praperadilan dalam menentukan keabsahan tersangka dapat mendukung, tetapi sekaligus dapat juga menjadi alat peruntuh demokrasi Pancasila.Kata kunci : praperadilan, Pancasila, penetapan tersangka, demokrasi
Performance Bounds For Co-/Sparse Box Constrained Signal Recovery
Authors: Kuske Jan , Petra Stefania 
Published: March 2019

Abstract
The recovery of structured signals from a few linear measurements is a central point in both compressed sensing (CS) and discrete tomography. In CS the signal structure is described by means of a low complexity model e.g. co-/sparsity. The CS theory shows that any signal/image can be undersampled at a rate dependent on its intrinsic complexity. Moreover, in such undersampling regimes, the signal can be recovered by sparsity promoting convex regularization like ℓ
1- or total variation (TV-) minimization. Precise relations between many low complexity measures and the sufficient number of random measurements are known for many sparsity promoting norms. However, a precise estimate of the undersampling rate for the TV seminorm is still lacking. We address this issue by: a) providing dual certificates testing uniqueness of a given cosparse signal with bounded signal values, b) approximating the undersampling rates via the statistical dimension of the TV descent cone and c) showing empirically that the provided rates also hold for tomographic measurements.
Increased cystatin F levels correlate with decreased cytotoxicity of cytotoxic T cells
Authors: Prunk Mateja , Nanut Milica Perisic , Sabotic Jerica , Svajger Urban , Kos Janko 
Published: March 2019

Abstract

Background
Cystatin F is a protein inhibitor of cysteine peptidases, expressed predominantly in immune cells and localised in endosomal/lysosomal compartments. In cytotoxic immune cells cystatin F inhibits both the major pro-granzyme convertases, cathepsins C and H that activate granzymes, and cathepsin L, that acts as perforin activator. Since perforin and granzymes are crucial molecules for target cell killing by cytotoxic lymphocytes, defects in the activation of either granzymes or perforin can affect their cytotoxic potential.

Materials and methods
Levels of cystatin F were assessed by western blot and interactions of cystatin F with cathepsins C, H and L were analysed by immunoprecipitation and confocal microscopy. In TALL-104 cells specific activities of the cathepsins and granzyme B were determined using peptide substrates.

Results
Two models of reduced T cell cytotoxicity of TALL-104 cell line were established, either by treatment by ionomycin or by immunosuppressive transforming growth factor beta. Reduced cytotoxicity correlated with increased levels of cystatin F and with attenuated activities of cathepsins C, H and L and of granzyme B. Co-localisation of cystatin F and cathepsins C, H and L and interactions between cystatin F and cathepsins C and H were demonstrated.

Conclusions
Cystatin F is designated as a possible regulator of T cell cytotoxicity, similar to its role in natural killer cells.
Ultralow anterior resection with implantation of gentamicin-collagen sponge and no defunctioning stoma: anastomotic leakage and local cancer relapse
Authors: Michalik Tomasz , Matkowski Rafał , Biecek Przemyslaw , Forgacz Jozef , Szynglarewicz Bartlomiej 
Published: March 2019

Abstract

Background
Anterior resection with total mesorectal excision (TME) of ultralow rectal cancer may result in the increased risk of the anastomotic leakage (AL). The aim of this study was to evaluate the usefulness of the gentamicin-collagen sponge (GCS) for the protection against symptomatic AL and investigate association between AL and local relapse (LR).

Patients and methods
A series of 158 patients with ultralow rectal cancer was studied. All the patients underwent R0 sphincter-saving TME with anastomosis wrapping using GCS. In none of the cases a temporary protective stoma was constructed.

Results
AL rate was 3.2% (5/158) while median time to AL diagnosis was 5 days following surgery (range 3-15). There was no postoperative and leakage-related mortality. Patient age > 75 years and smoking were independent risk factors related to significantly increased AL rate: 12.5% vs. 0.8% (P = 0.0004) and 5.7% vs. 0% P = 0.043), respectively. LR was observed in 12% of cases. It was highly significantly more common and developed earlier in patients who have had AL when compared with non-AL group: 80% vs. 9% (P = 0.00001) and 8.5 vs. 17 months (P = 0.014), respectively.

Conclusions
Anastomosis wrapping with GCS after anterior resection with TME is a safe procedure resulting in the low incidence of anastomotic leakage which may be also associated with decreased risk of local relapse.
Relationships between soil pH and base saturation – conclusions for Polish and international soil classifications
Authors: Kabała Cezary , Łabaz Beata 
Published: March 2019

Abstract
Taking into account the fact that (a) measurement of the cation exchange capacity and base saturation is practically unavailable in the field, that formally makes impossible the reliable field classification of many soils, (b) base saturation is measured or calculated by various methods those results significantly differ, (c) base saturation and soil pH are highly positively correlated, it is suggested to replace the base saturation with pHw (measured in distilled/deionized water suspension) in the classification criteria for diagnostic horizons and soil units/subunits, both in the Polish Soil Classification and FAO-WRB. Based on statistical analysis of 4500 soil samples, the following pHw values are recommended instead of 50% base saturation: pHw <5.5 for umbric and pHw ≥5.5 for the mollic horizon, and for Chernozems, Kastanozems, Phaeozems (directly) and Umbrisols (indirectly). Furthermore, the pHw <4.7 may feature the Dystric qualifier in mineral soils and respective Reference Soil Groups of WRB; while the pHw ≥4.7 may feature the Eutric qualifier. The distinction between subtypes of the brown soils in the Polish Soil Classification may base on the pHw 4.7 or 5.0, but using different requirements of pH distribution in the depth control section. The replacement of the base saturation with pH refers to the formal soil classification only, and does not exclude the use of base saturation for professional soil characteristics.
Seca Regulatory Impact Assessment: Administrative Burden Costs in the Baltic Sea Region
Authors: Olaniyi Eunice O. , Prause Gunnar 
Published: March 2019

Abstract
After three years of 0.1% Sulphur limit of the Sulphur Emission Control Area (SECA) enforcement, empirical results have shown that the fears that SECA regulation would be a disadvantage for the Baltic Sea maritime sector are unfounded. Results have also shown commendable compliance rate and improved environmental conditions for the BSR. Nonetheless, there is still a need to clear the air regarding the costs information obligations that are required from maritime actors regarding their compliance activities. These activities are arguably obviously needful but could also lead to an unintended increase of costs of regulations.
Using a BSR-wide survey and case studies, the paper identified SECA information obligations related to the shipowners from shipping line whose vessels ply the SECA waters. The authors further evaluated the costs of the administrative burden related to these tasks.
The results show that the administrative burden for SECA regulations is different for shipowners and maritime authorities.