bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Phase I Study of Alpha-1,3-Galactosyltransferase-Expressing Allogeneic Renal Cell Carcinoma Immunotherapy in Patients with Refractory Metastatic Renal Cell Carcinoma
Authors: Hahn Andrew W. , Drake Charles , Denmeade Samuel R. , Zakharia Yousef , Maughan Benjamin L. , Kennedy Eugene , Link Charles , Vahanian Nicholas , Hammers Hans , Agarwal Neeraj 
Published: September 2019

Abstract

Lessons Learned
HyperAcute Renal immunotherapy was well tolerated and demonstrated antitumor activity in patients requiring salvage-line treatment for metastatic renal cell carcinoma (mRCC). HyperAcute Renal immunotherapy was safely administered with concomitant salvage-line treatments for mRCC, and it may be a candidate for inclusion in novel combinations for salvage treatment of mRCC because of its unique mechanism of action.

Background
HyperAcute Renal (HAR) immunotherapy exploits a naturally occurring barrier to xenotransplantation and zoonotic infections in humans to immunize patients against metastatic renal cell carcinoma (mRCC) cells. HAR consists of two allogeneic renal cancer cell lines genetically modified to express α(1,3)Gal, to which humans have an inherent pre-existing immunity.

Methods
Patients with refractory mRCC were eligible for this phase I dose-escalation trial. Concomitant treatment was permitted after the initial 2 months of HAR monotherapy. HAR was injected intradermally weekly for 4 weeks then biweekly for 20 weeks, totaling 14 immunizations. The primary endpoint was safety and determination of a maximum tolerated dose (MTD).

Results
Among 18 patients enrolled, two grade 3 adverse events (AEs) were attributed to HAR, lymphopenia and injection site reaction, and no grade 4/5 AEs occurred. The recommended phase II dose (RP2D) was 300 million cells. One patient had a partial response and eight patients had stable disease, for a disease control rate of 50% (9/18). Median overall survival with low-dose HAR was 14.2 months and was 25.3 months with high-dose HAR.

Conclusion
In pretreated mRCC, HAR immunotherapy was well tolerated and demonstrated antitumor activity. HAR immunotherapy may be a candidate for inclusion in novel combinations for salvage treatment of mRCC.
Burden of CKD and Cardiovascular Disease on Life Expectancy and Health Service Utilization: a Cohort Study of Hong Kong Chinese Hypertensive Patients
Authors: Wan Eric Yuk Fai , Yu Esther Yee Tak , Chin Weng Yee , Fong Daniel Yee Tak , Choi Edmond Pui Hang , Tang Eric Ho Man , Lam Cindy Lo Kuen 
Published: September 2019

Significance Statement
The relative effects of the burdens of CKD and cardiovascular disease on risk of mortality, direct medical costs, and life expectancy in people with hypertension are unknown. In this retrospective cohort study of 506,849 patients with hypertension in Hong Kong, co-occurrence of these conditions was associated with significant incrementally elevated mortality risk, direct medical costs, and reduced life expectancy. The authors found extremely high mortality risk and cost increases for severe CKD, exceeding the combined effects from heart disease and stroke. Moderate CKD, heart disease, and stroke had burdens that were similar individually and roughly multiplicative for any combination. These findings suggest that CKD prevention and intervention to reduce mortality and health care costs in people with hypertension should be given priority equal to that for cardiovascular disease.

Background
The relative effects of combinations of CKD, heart disease, and stroke on risk of mortality, direct medical costs, and life expectancy are unknown.

Methods
In a retrospective cohort study of 506,849 Chinese adults in Hong Kong with hypertension, we used Cox regressions to examine associations between all-cause mortality and combinations of moderate CKD (eGFR of 30–59 ml/min per 1.73 m2), severe CKD (eGFR of 15–29 ml/min per 1.73 m2), heart disease (coronary heart disease or heart failure), and stroke, and modeling to estimate annual public direct medical costs and life expectancy.

Results
Over a median follow-up of 5.8 years (2.73 million person-years), 55,666 deaths occurred. Having an increasing number of comorbidities was associated with incremental increases in mortality risk and medical costs and reductions in life expectancy. Compared with patients who had neither CKD nor cardiovascular disease, patients with one, two, or three conditions (heart disease, stroke, and moderate CKD) had relative risk of mortality increased by about 70%, 160%, and 290%, respectively; direct medical costs increased by about 70%, 160%, and 280%, respectively; and life expectancy at age 60 years decreased by about 5, 10, and 15 years, respectively. Burdens were higher with severe CKD.

Conclusions
This study demonstrated extremely high mortality risk and medical cost increases for severe CKD, exceeding the combined effects from heart disease and stroke. Mortality risks and costs for moderate CKD, heart disease, and stroke were similar individually and roughly multiplicative for any combination. These findings suggest that to reduce mortality and health care costs in patients with hypertension, CKD prevention and intervention merits priority equal to that of cardiovascular disease.
Live Birth and Endometrial Thickness in Unexplained Infertility
Authors: OVAYOLU Ali , GÜN İsmet , BENK ŞİLFELER Dilek , KUTLU Tayfun 
Published: September 2019

Objective: We aimed to demonstrate any possible relationship between endometrial thickness on the day of hCG trigger and live birth rates (LBRs) among women with unexplained infertility who underwent IVF/ICSI-ET cycles. Materials and Methods: We retrospectively collected data from Zeynep Kamil Women's and Children's Disease Training and Research Hospital, IVF Center archive. Cases between 2005 and 2013 were collected. Women aged between 23-39 years with a BMI &lt;30 kg/m2 with fresh embryo transfers were included. Patients were divided into two groups based on their livebirth status (live birth: group 1, no live birth: group 2). Demographic characteristics, treatment regimens, and endometrial thickness on the day of hCG trigger were compared between the two groups. In addition, patients were divided into subgroups according to the endometrial thickness on the day of hCG trigger (≤7 mm, 8 mm, 9 mm, 10 mm, 11 mm, 12 mm, 13 mm, and ≥14 mm, respectively). LBRs were compared between these subgroups. Results: Three hundred fifty-nine cycles (group 1: n=104, group 2: n=255) were included for statistical analysis. Other than estradiol level (pg/mL) on the day of hCG trigger (2517.2±1106.0, 2210.8±991.7, respectively; p=0.011), there were no statistically significant differences between the two groups. Among the subgroups based on endometrial thickness, the highest LBR was detected in the 13 mm subgroup (36.8%) and lowest LBR was detected in 12 mm subgroup (23.9%). However, LBRs were not statistically significant between the subgroups. Conclusion: LBRs do not seem to be affected by endometrial thickness on the day of hCG trigger among couples with unexplained infertility.
The influence of clinical, pathological and surgical factors on the occurrence of recurrence of borderline ovarian tumors in different age groups
Authors: Novikov F. V. , Bondarev V. P. , Mishina E. S. , Mnikhovich M. V. 
Published: September 2019

Background. Borderline ovarian tumors (BOT), due to their unclear biological potential, remain a problem for oncogynecologists. On the one hand, frequent recurrences of tumors, and on the other hand, a high survival rate in the diagnosis of patients requires careful weighing of all risk factors when choosing surgical intervention tactics in patients with BOT. A large number of recurrences of BOT in patients of fertile age lead to disability of patients, deterioration of their quality of life and loss of reproductive function.Objective: evaluation of the influence of clinical and morphological factors (the presence of non-invasive implants, bilateral lesion of the ovaries, the presence of psammous bodies and malignization tricks) and surgical factors (damage to the cyst capsule and carrying out fertility preserving operations) on the recurrence of BOT in various age groups.Materials and methods. The material for the study was the protocols of an in vivo pathoanatomical study of a biopsy (surgical) material obtained from patients with a diagnosis of BOT for the period from 2000 to 2017 inclusive, according to the Regional Forensic Medical Bureau of Kursk. A total of 110 protocols for the first occurrence of BOT and 14 protocols for the tumor recurrences were analyzed. The age of patients undergoing an in vivo pathologic examination ranged from 19 to 75 years.Results and conclusions. It has been revealed that psammous bodies, fertility preserving operations and reproductive age are associated with tumor recurrence. Groups of patients with foci of malignancy and bilateral lesions have a lower risk of BOT recurrence due to the radical surgical treatment tactics and possibly the use of chemotherapy in the first case. Non-invasive implants are not associated with the risk of BOT recurrence.
Peritoneal simple mesothelial cyst: a case report
Authors: Popov Yu. V. , Vanke N. S. , Kedrova A. G. 
Published: September 2019

Primary retroperitoneal cysts are rare benign growths that are often random findings during diagnostic examinations or surgical treatment. The classification, etiology and clinical manifestations of retroperitoneal cysts are the subject of interdisciplinary debate. The most reliable test for their detection is ultrasound and computed tomography. Based on the available literature data, primary cysts of the retroperitoneal space are subject to complete removal within healthy tissues.We present a clinical case of intraoperative detection of a large-sized retroperitoneal cyst in a 42-year-old woman hospitalized in the gynecological department of the Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation, for surgical treatment of uterine myoma. During the planned surgical treatment revealed the presence of cystic formation of large sizes in the right anterior pararenal space. The final diagnosis was made after a pathological examination. Histologically, the inner epithelial lining of the cystic formation contained multiple ciliary cells, forming papillary structures similar in some areas, with folds of the mucous membrane of the fallopian tube.
An Examination of 3D Printing in Dentistry - A Study
Authors: CİRAK Bekir 
Published: September 2019

This study examines the design
and production processes of a small molar tooth produced with a 3D printer.
When designing the exercises, polygons and parabolic forms were used as output
points. These forms, which are rendered in three dimensions in the computer
environment, are formed taking into consideration the structural
characteristics of the production material. PLA (Polylactic Acid )
material is used in this design which is produced in three dimensional printer
by FDM (Fused Deposition Modeling) method. In the scope of the study, the
conditions experienced in the design of the material used were mentioned and
the material mistake was given during printing. The different effects of the
commands used in the design process on the production surfaces, as well as
voluntary or involuntary faults, are very important in the formation of some
deformations and are caused by the plastic nature of the material. In addition,
the effects of PLA on the surface of the faults are investigated. However,
different methods applied in the production of sole parts and surfaces have
been evaluated.
Organizaciones que aprenden
Authors: Lugo Faneite Alexander Jose , Florez Ruiz Jose 
Published: September 2019

El presente artículo aborda la importancia que tienen en el contexto actual las organizaciones que aprenden a aprender, en un mundo globalizado y de constantes cambios que exige el proceso adquisición de conocimiento, trasformación gerencial, para estar a la vanguardia, alcanzar el éxito y ser una organización altamente competitiva, en la realidad empresarial del siglo XXI. Se llevó a cabo un análisis teórico bajo un diseño bibliográfico que permitió definir, describir y explicar, vía inferencia deductiva las organizaciones que aprenden a aprender, el pensamiento prevaleciente de los sujetos y equipos que aprenden en las organizaciones sistémicas, el cambio, los contextos complejos y la gestión de la incertidumbre como recursos que potencializan el aprendizaje, la construcción de conocimiento organizacional y finalmente las vías aproximativas para aprender y construir conocimiento. Las reflexiones finales a modo de conclusión reflejan que la creación continua de conocimiento organizativo, es la clave para asegurar la evolución de la organización y garantiza que la organización cambie, trascienda y evolucione.
Detection of HBV DNA by PCR and its application in clinical transfusion
Authors: Li Shunqing 
Published: September 2019

<p><strong><em> </em></strong>This study was to detect the hepatitis B virus (HBV) DNA copies in patients through blood transfusions; recessive carriers with HBsAg negative but HBV DNA positive were further studied to see the content and distribution of HBV in patients, and provide evidence for the clinical treatment. A total of 532 blood samples collected from July 2014 to July 2015 were tested for HBV-DNA viral load and hepatitis B serological markers using quantitative Polymerase Chain Reaction (qPCR) and serologic test (five serological markers of hepatitis B). The results showed that, 3 cases were HBV serology negative and the HBV-DNA viral load was in the range of 250-500 whereas only 1 case was HBsAb positive and the HBV-DNA viral load was above 500. qPCR, for detecting HBV DNA, together with serological routine test can effectively reduce HBV infection during transfusion and prevent medical disputes.</p>
Colonic pseudo-obstruction; Ogilvie syndrome; neostigmine; decompression; caecostomy
Authors: Hong Michael K-Y , Turner Catherine E , Blomberg David N , Morgan Matthew J 
Published: September 2019

<p class="BodyText1">Acute colonic pseudo-obstruction is characterised by massive colonic distension without distal mechanical obstruction. It affects a wide variety of patients who often have multiple comorbidities, which makes studies on pseudo- obstruction difficult to perform and interpret. Few advances have been made in recent years in our understanding and management, which remain challenging. This article explores and provides interpretation of the key studies and concepts that have shaped our management of this condition. </p>
Overview of the use of clean cookstoves in the Brazilian semiarid region
Authors: Mazorra Javier , Da Costa Barreto Renata , Ferreira dos Santos Paula , Suárez Bonet María , De la Sota Candela , Checco Guilherme , Almeida Fabio , Tadeu Assad Luís 
Published: September 2019

Wood cookstoves are common in the Brazilian semiarid region. Most families use traditional versions,which have a series of social, environmental and health-related impacts. “Improved cookstoves” referto cleaner and more efficient cookstoves. These include adaptations that improve energy efficiency and reduce indoor air pollution, bringing benefits such as the reduction of firewood consumptionfor cooking, reduction of the emission of polluting gases originating from firewood burning andfewer health impacts, also contributing to forest conservation. Although the improved cookstovessector is still relatively underdeveloped in the Brazilian semiarid region, in recent years interest inthese technological alternatives has increased. In this context, the present study contributes to thecompilation and organization of information referring to the use of improved cookstoves in the Braziliansemiarid region.
THE DEVELOPMENT OF ACCOUNTING LEARNING MANAGEMENT ON CURRICULUM 2013 BASED ON LESSON STUDY AT VOCATIONAL SCHOOL IN SURAKARTA CITY, CENTRAL JAVA, INDONESIA
Authors: Suyatmini  , Sarjono Yetty , Asmawati Titik , Rohmah Wafrotur 
Published: September 2019

Purpose: The purpose of this research is to analysis and to describe the development of accounting learning management on curriculum 2013 based on lesson study.
Methodology: This research approach used was research and development. The subject of the study is accounting vocational school teachers at Surakarta. The method research data collection used were observation, interview, and documentation. This research also used focus group discussion. The data analysis technique used interactive analysis that involved: data collection, reduction, display, and verification.
Main finding: The research results showed that 1) this following steps did the development of learning: (a) syllabus studying; (b) the learning material identification; (c) the determination of learning goal; (d) the development of learning activity; (e) the explanation of assessment kinds that will be used; f) the division of time allocating and (g) the determination of study resources. 2) The development of learning conducting was done by (a) the learning activity that designed so that teachers can perform the learning process professionally (b) the learning activity was organized to be activated, such as Introduction, main activity, and closing. The main event was explained as: exploration, elaboration, and confirmation, in the form of to observe, to ask, to collect information to socialize and to communicate. 3) The development of learning evaluation was done by using test and nontest in the formed of written test (paper and pencil test) or spoken, job observing, attitude measurement, assessment of job result, such as: assignment, project and/or product, portfolio usage, and self-assessment.
Implication: This finding can help accounting Vocational School teachers in managing accounting learning with the 2013 curriculum.Novelty: The results show the development in the management of accounting learning both in the preparation of learning plans, implementation of learning, and evaluation of learning.
Analysis on Chinese Airline Network Invulnerability
Authors: Yang Yong , Xu Kaijun , Xiang Honghui 
Published: September 2019

AbstractAir transportation systems are often subject to failures or attacks induced by unexpected abominable weather or temporal airspace occupation, while complex networks have been springing up as a convenient yet efficient tool to represent and analyze various realistic complex systems such as realistic airline system. In terms of Chinese airline network formed during the spring festival timespan, structural empirical research and invulnerability simulation analysis against various deliberate attack strategies were made using complex network theory, where nodes and edges denotes domestic airports and direct flights between them respectively. The analysis results indicate: The presented airline network is a small net-work with scale-free characteristics, and correlation shows remarkable hierarchical structure and obvious assortative characteristics; The network shows obvious invulnerability under deliberate node attack, while shows partly robustness under edge attack even with obvious attack effects against various attack strategies.
A Robust Iterative Method for Flash Calculations Using the Soave-Redlich-Kwong or the Peng-Robinson Equation of State
Authors: Nghiem Long X. , Aziz Khalid 
Published: September 2019

ABSTRACT
A robust algorithm for flash calculations using the Soave-Redlich-Kwong or Peng-Robinson equation of state is presented. It first uses a special version of the Successive Substitution method and switches to Powell's method if poor convergence is observed. Criteria are established for an efficient switch from one method to the other. Experience shows that this method converges near the bubble-, dew- or critical point and detects also the single-phase region without computing the saturation pressure.

INTRODUCTION
The calculation of vapor-liquid equilibrium using an equation of state in multicomponent systems yields a system of non-linear equations which must be solved iteratively. The method of Successive Substitution is commonly used but it exhibits poor rate of convergence, or in some cases no convergence, near the dew-, bubble or critical point. To overcome convergence problems, Newton's method has been used by Fussel and Yanosik1 to solve the equations. The drawback of Newton's method is the necessity of computing a complicated Jacobian matrix and its inverse at every iteration. Hence, for systems removed from their dew-, bubble- or critical point it involves more work to arrive at the solution than the method of Successive Substitution. The single-phase region is usually determined by computing the saturation pressure and comparing it with the pressure of the system. This requires additional work and it is sometimes difficult to decide whether dew point or bubble point pressure should be computed (they involve different equations).
Assessing Quality Improvement Capacity in Primary Care Practices
Authors: Parchman Michael , Anderson Melissa L. , Coleman Katie F , Michaels LeAnn , Schuttner Linnaea , Conway Cullen , Hsu Clarissa , Fagnan Lyle J. 
Published: September 2019

Abstract
Background: Healthy Hearts Northwest (H2N) is a study of external support strategies to build quality improvement (QI) capacity in primary care with a focus on cardiovascular risk factors: appropriate aspirin use, blood pressure control, and tobacco screening/cessation.

Methods: To guide practice facilitator support, experts in practice transformation identified seven domains of QI capacity and mapped items from a previously validated medical home assessment tool to them. A practice facilitator (PF) met with clinicians and staff in each practice to discuss each item on the Quality Improvement Capacity Assessment (QICA) resulting in a practice-level response to each item. We examined the association between the QICA total and sub-scale scores, practice characteristics, a measure of prior experience with managing practice change, and performance on clinical quality measures (CQMs) for the three cardiovascular risk factors.

Results: The QICA score was associated with prior experience managing change and moderately associated with two of the three CQMs: aspirin use (r=0.16, p=0.049) and blood pressure control (r=0.18, p=0.013). Rural practices and those with 2-5 clinicians had lower QICA scores. PFs notes provide examples of high scoring practices devoting time and attention to quality improvement whereas low scoring practices did not.

Conclusions: The QICA is useful for assessing QI capacity within a practice and may serve as a guide for both facilitators and primary care practices in efforts to build this capacity and improve measures of clinical quality.
ItChIP-simultaneous indexing and tagmentation-based ChIP-seq
Authors: Ai Shanshan , Xiong Haiqing , Li Chen C. , Luo Yingjie , Liu Yaxi , Yu Xianhong , He Aibin 
Published: September 2019

Abstract
Single-cell measurement of chromatin states, including histone modifications and non-histone protein binding, remains challenging. We present a low-cost, efficient ChIP-seq (simultaneous indexing and tagmentation-based ChIP-seq, itChIP), compatible to both low-input and single cells for profiling chromatin states. This single-cell itChIP approach combines chromatin opening, simultaneous cellular indexing and chromatin tagmentation in a single tube, processing samples with tens of single cells in rarity or with thousands of single cells per assay, and the entire procedure can be finished in two days. The sc-itChIP data acquire ~9,000 unique reads per cell, sufficiently capturing the earliest epigenetic priming along cell fate transition and the basis for cell-type specific enhancer usage. Our results demonstrate that itChIP is a generalizable technology for single-cell chromatin profiling of epigenetically heterogeneous cell populations in many biological processes. This step-by-step protocol is related to the publication “Profiling chromatin state by single-cell itChIP-seq” in Nature Cell Biology.