bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obesity, white adipose tissue and cancer
Authors: Solsona‐Vilarrasa Estel , Vousden Karen H. 
Published: November 2024

White adipose tissue (WAT) is crucial for whole‐body energy homeostasis and plays an important role in metabolic and hormonal regulation. While healthy WAT undergoes controlled expansion and contraction to meet the body's requirements, dysfunctional WAT in conditions like obesity is characterized by excessive tissue expansion, alterations in lipid homeostasis, inflammation, hypoxia, and fibrosis. Obesity is strongly associated with an increased risk of numerous cancers, with obesity‐induced WAT dysfunction influencing cancer development through various mechanisms involving both systemic and local interactions between adipose tissue and tumors. Unhealthy obese WAT affects circulating levels of free fatty acids and factors like leptin, adiponectin, and insulin, altering systemic lipid metabolism and inducing inflammation that supports tumor growth. Similar mechanisms are observed locally in an adipose‐rich tumor microenvironment (TME), where WAT cells can also trigger extracellular matrix remodeling, thereby enhancing the TME's ability to promote tumor growth. Moreover, tumors reciprocally interact with WAT, creating a bidirectional communication that further enhances tumorigenesis. This review focuses on the complex interplay between obesity, WAT dysfunction, and primary tumor growth, highlighting potential targets for therapeutic intervention.
Feature Transfer Learning for Fatigue Life Prediction of Additive Manufactured Metals With Small Samples
Authors: Wu Hao , Fan Zhi‐Ming , Gan Lei 
Published: November 2024

ABSTRACTA feature transfer learning (FTL)‐based model is proposed to address small‐sample problems in fatigue life prediction of additively manufactured (AM) metals. Transfer component analysis (TCA) is studied for data alignment before model training. Correspondingly, two TCA improvement strategies are further considered to aggregate training data from distinct AM processing conditions. An experimental database consisting of 103 fatigue data is built for model evaluation. The results demonstrate that the proposed model outperforms conventional machine learning models and other transfer learning‐based models in terms of accuracy and data demand, showing good applicability for AM fatigue life assessment.
Parent Involvement in Post‐School Transition Services for Senior High School Students With Intellectual Disabilities
Authors: Hsieh Yu‐Jung , Ho Wei‐Sho , Sun Shu‐Jou 
Published: November 2024

ABSTRACTBackgroundParents play a key role in the transition process of their children. After high school students with intellectual disabilities leave the school system, they need the cooperation of schools and families to ensure successful employment and independent living.MethodsA case study was conducted in a Taiwanese high school special education class, collecting data from 12 participants through interviews, documents and diaries.ResultsThe results showed that active parental involvement in transition activities, strong parent–teacher partnerships, understanding of students' strengths and support from social resources were key to successful transitions.ConclusionsThis study explored the effectiveness and difficulties of parents' participation in the post‐school transition of students with intellectual disabilities from the perspectives of teachers, parents and students. Finally, it proposed the need to be the child's significant other, early participation in transition planning and joint involvement of parents and their children.
Safety and efficacy of endoscopic submucosal dissection with gel immersion technique for superficial esophageal neoplasms
Authors: Iwatsubo Taro , Hakoda Akitoshi , Sugawara Noriaki , Sasaki Shun , Nakajima Noriyuki , Mori Yosuke , Tanaka Hironori , Ota Kazuhiro , Takeuchi Toshihisa , Nishikawa Hiroki 
Published: November 2024

AbstractBackground and AimGel immersion (GI) endoscopy provides a good visual field in endoscopic submucosal dissection (ESD); however, its clinical outcomes are poorly understood. This study aimed to compare the treatment outcomes between esophageal gel immersion endoscopic submucosal dissection (GI‐ESD) and conventional ESD (C‐ESD) to determine the safety and efficacy of GI‐ESD.MethodsThe data of 71 consecutive patients who underwent esophageal ESD between April 2021 and March 2023 at a Japanese tertiary center were retrospectively reviewed. GI was achieved using an additional irrigation tube. The treatment outcomes between the GI‐ESD and C‐ESD groups were compared using inverse probability of treatment weighting (IPTW) to control for confounding factors.ResultsA total of 75 superficial esophageal epithelial neoplasms (41 in the C‐ESD and 34 in the GI‐ESD groups) were treated using ESD. The mean procedure time in the GI‐ESD group was significantly shorter than that in the C‐ESD group (59.2 ± 36.2 vs 85.3 ± 45.7 min, P = 0.008). After IPTW adjustment, the mean procedural times were 62.6 ± 36.6 and 82.9 ± 41.7 min in the GI‐ESD and C‐ESD groups, respectively (P = 0.037), and the incidence rate of muscle layer damage was 4.2% in the GI‐ESD group and 30.6% in the C‐ESD group (P = 0.001). In the multivariate analysis, specimen size ≥ 30 mm (odds ratio [OR]: 9.44, 95% confidence interval [CI]: 2.46–36.30, P = 0.001) was positively correlated with longer procedural time (≥ 90 min), whereas GI‐ESD (OR: 0.19, 95%CI: 0.05–0.68, P = 0.011) showed a negative association.ConclusionsEsophageal GI‐ESD may be useful in terms of safety and time efficiency. The GI technique could be an option for esophageal ESD.
Interventions to improve vitamin and mineral inadequacies among children in India: a scoping review
Authors: Mathias Edlin Glane , Halemani Kurvatteppa , Lobo Ameeka Shereen , Bhat Latha Thimappa 
Published: November 2024

AbstractIntroductionVitamin and mineral deficiencies are commonly seen in children, and they affect the physical, mental and cognitive development of a child.ObjectiveThis study aimed to map interventions to improve vitamin and mineral inadequacies among children in India.MethodsA review was conducted using the PRISMA extension for scoping reviews (PRISMA‐ScR) 2018 checklist. Based on the PICO framework, further steps were followed in conducting the review. Studies conducted on children and adolescents (ranging in age from 6 months to 19 years) in India were considered. A search was carried out in PubMed, CINAHL, ProQuest, Cochrane Library, Scopus and Web of Science. Interventions that focused on improving vitamin and mineral inadequacies were collated. Studies published in the English language between 1 January 2012, and 30 September 2023, were included. The data from the included studies were reported narratively.ResultsThe search yielded 1566 records through the databases. Finally, 18 studies were found to be eligible to be considered in this review. For improving vitamin and mineral deficiencies, different types of supplements like iron, vitamins A, C and D in different amounts; nutritional supplements like zinc‐rich foods, whole‐wheat recipes, milk, lipid‐based vitamin B12 supplements, ragi, porridge and iron‐fortified whole‐wheat drinks; or nutritional counselling worked better in children.ConclusionVitamin and mineral supplementation for children reduces anaemia among children. Policymakers need to develop a strategy to increase awareness among parents, AWWs, caregivers and schoolteachers to reduce further complications.
The Predictive Effect of the Level of Psychological Resilience on the Level of Readiness for Discharge in Patients Undergoing Orthopaedic Surgery
Authors: Gündüz Emine Selda , Durmaz Melike , Aydin Bahattin Kerem 
Published: November 2024

ABSTRACTAimThe aim of this study is to establish the correlation between the degree of psychological resilience and readiness for discharge in patients undergoing orthopaedic surgery.DesignThis study is of a descriptive correlational type.Material and MethodThis study comprised a cohort of 190 patients who were admitted to the orthopaedics and traumatology department and had surgical procedures performed between November 2023 and April 2024. The study data were gathered via completion of the Introductory Information Form, the Psychological Resilience Scale and the Hospital Discharge Readiness Scale. IBM SPSS 25 package program was used to analyse the research data.ResultsIn this study, 34.2% of the participants stated that they did not feel ready for discharge. Predictors of Readiness for Hospital Discharge were identified as being male (β = 0.118, p = 0.003), living alone (β = 0.222, p < 0.001), having undergone prosthesis, fracture or amputation surgery (β = 0.161, p < 0.001), not having received discharge training (β = 0.122, p = 0.001), not feeling ready for discharge (β = 0.442, p < 0.001) and resilience (β = 0.246, p < 0.001). These variables were found to explain 88.7% of Readiness for Hospital Discharge (adjusted R2 = 0.773).ConclusionThe findings of this study emphasise that including patients in their healthcare and creating comprehensive discharge plans tailored to their specific care requirements have a beneficial impact on their readiness for discharge. Additionally, the study demonstrates that enhancing psychological resilience plays a mediating role in facilitating discharge readiness.Implications for the Patient CarePatients who feel ready for discharge are less likely to be hospitalised and their recovery may be faster. Including the patient in the discharge plan, taking individual needs into consideration and disseminating programmes to increase resilience should be an integral part of holistic care.Reporting MethodThe STROBE checklist was applied in the reporting of the finding.
Ethical and Regulatory Challenges of Generative Artificial Intelligence in Healthcare: A Chinese Perspective
Authors: Yu Lanyi , Zhai Xiaomei 
Published: November 2024

ABSTRACTAimTo provide practical insights that delve into the ethical issues and regulatory implications of generative artificial intelligence (GenAI) in healthcare. Ethical Challenges and Regulatory Impact in China is used as an example.BackgroundDespite China's efforts to strike a delicate balance between protecting public welfare and promoting technological advancement, numerous unresolved issues persist in the practical integration of generative artificial intelligence into healthcare settings.ConclusionKey issues such as data application, privacy protection, cost‐effectiveness and regulatory remain areas of ambiguity that require clarification. Stringent ethical guidelines, data privacy protection measures and continuous supervision and evaluation of artificial intelligence decisions will help enhance the expected benefits of GenAI in healthcare.Relevance to Clinical PracticeThe potential use of GenAI in healthcare has garnered widespread attention, emerging as a significant global research topic. However, its application in this domain presents substantial ethical and regulatory challenges. Compared to other fields, GenAI's role in healthcare is more sensitive and complex, necessitating an urgent assessment of its ethical implications for future development and deployment. Challenges and ethical considerations are particularly pronounced in developing countries with limited healthcare resources.
What Are the Infection Prevention Behaviors of Kidney Transplant Recipients and the Factors Related to These?
Authors: Sarıgöl Ordin Yaprak , Karakılçık Bahar 
Published: November 2024

ABSTRACTBackgroundThe infection prevention behaviours of kidney transplant recipients have been investigated, but the factors affecting these have not. Therefore, the present study aimed to examine the infection prevention behaviours of kidney transplant recipients and the factors related to these.MethodsThe sample of this descriptive, cross‐sectional study included 148 kidney transplant recipients being followed in a kidney transplant outpatient clinic. Data were collected with a sociodemographic and clinical characteristics form, the Adherence to Measures against Infections Questionnaire and the Self‐Control and Self‐Management Scale between November 2022 and May 2023.ResultsThe mean age of the patients was 50.29 ± 13.11 years. The rate of self‐reported hand hygiene was 51%. Age caused a significant difference in receiving a vaccine against pneumonia and wearing a mask. The rate of self‐reported behaviour of rinsing vegetables was higher among the married patients compared to single patients. Self‐management created a significant difference in receiving a vaccine against influenza and pneumonia, eating salad in a café or restaurant and wearing a mask outside home and consuming raw food, delicatessen products and street food (p < 0.05).ConclusionThis study revealed that the kidney transplant recipients displayed incomplete infection prevention behaviours including hand hygiene. Infection prevention behaviours differed in terms of age and self‐control and self‐management. Education and interventions are needed to improve the infection prevention behaviours of kidney transplant recipients.Relevance to Clinical PracticeThis study illustrates the characteristics of, and relationship between, sociodemographic factors and self‐management of infection prevention behaviours in kidney transplant recipients.Reporting MethodStrengthening the reporting of cross‐sectional studies (STROBE) was followed.Patient ContributionThe study demonstrates that there is a need for interventions that will improve both the self‐management levels and infection protection behaviours of patients. Studies conducted in this direction will lead to a decrease in the infection rates of patients.
Prevalence and Influence Factors of Cognitive Frailty in the Older Adult Patients Undergoing Maintenance Haemodialysis: A Multi‐Centre Cross‐Sectional Study
Authors: Li Siyu , Huang Li , Wang Wenmian , Zeng Jing 
Published: November 2024

ABSTRACTAimsTo examine the prevalence of factors of cognitive frailty in patients undergoing maintenance haemodialysis (MHD).DesignA cross‐sectional study.MethodsFrom September 2023 to January 2024, 1023 patients undergoing MHD were recruited from 11 hospitals in Chengdu, China, using convenience sampling. The participants' sociodemographic and lifestyle factors, health information and laboratory indicators were assessed using a general information questionnaire. Cognitive frailty was assessed using the Fried Frailty Phenotype and Montreal Cognitive Assessment Scales. Multivariate logistic regression was used to examine the associations between cognitive frailty and sociodemographic and clinical characteristics. Independent variables for the multivariate logistic regression model encompassing age, sex, educational level, marital status, visual impairment, hearing impairment, falls within a year, depression, weight, height, Malnutrition‐inflammation score and serum albumin, sodium, phosphorus, total cholesterol and creatinine levels.ResultsAmong 1023 participants with a mean age of 69.52 years, 300 (29.3%) had cognitive frailty, with a predominance of older patients. Regression analysis showed that advanced age, low literacy and low serum creatinine, sodium and total cholesterol levels were positively correlated with cognitive frailty. Furthermore, 17.1% of the participants experienced depression, a risk factor for cognitive frailty, and malnutrition was an independent risk factor for cognitive frailty.ConclusionOlder adult patients undergoing (MHD) are at an increased risk of developing cognitive frailty. The aetiology of cognitive frailty in this cohort was multifactorial. Targeted interventions should be designed and implemented based on these factors, prioritising nutritional guidance and mood management to prevent or reverse cognitive frailty.Reporting MethodThe study adhered to the STROBE checklist.ImpactOlder adult patients undergoing MHD are at increased risk of developing cognitive frailty. Cognitive frailty screening must be incorporated into the routine assessment of older patients undergoing MHD.Patient or Public ContributionNo patient or public contribution.
Family Resources and Parental Problem‐Solving Skills Mediate Family Functioning and Family Adaptation in Families of Children With Cancer
Authors: Zhou Tianji , Xiong Wenjin , Meng Zhenyu , Yu Nancy Xiaonan , Zhang Jingping , Luo Yuanhui 
Published: November 2024

ABSTRACTAimsTo explore the mediating roles of family resources (at the individual [parental self‐efficacy], family [family resilience] and social level [social support]) and parental problem‐solving skills in the association between family functioning and family adaptation in families of children with cancer.DesignA cross‐sectional study.MethodsThis study recruited 318 parents of children with cancer from three tertiary hospitals in mainland China. Self‐report questionnaires were used to collect data on key variables, including family functioning, parental self‐efficacy, family resilience, social support, parental problem‐solving skills and family adaptation. Data analyses were carried out using descriptive analysis, univariate analysis, Pearson correlation analysis, hierarchical linear regression and bootstrapping.ResultsFamily functioning was significantly and positively correlated with family adaptation. Family resources (parental self‐efficacy at the individual level, family resilience at the family level or social support at the social level) and parental problem‐solving skills both independently mediated the relationship between family functioning and family adaptation. Additionally, family resources at all three levels mediated the relationship through their effects on cumulatively parental problem‐solving skills, constructing a chain mediating model.ConclusionsThe study underscores the significance of family functioning, family resources at the individual, family and social levels and parental problem‐solving skills in promoting adaptation in families of children with cancer. It highlights the need for family‐centred interventions targeted at these factors to improve family adaptation.ImpactThis study extended related theories and previous studies to confirm the mediating role of family resources and parental problem‐solving skills, both independently and sequentially. Moreover, parental problem‐solving skills were confirmed as key elements that can be incorporated into future interventions, suggesting that problem‐solving skills training may serve as a highly promising program for families of children with cancer.Reporting MethodThis study was reported according to the STROBE checklist.Patient or Public ContributionNo Patient or Public Contribution.
Conditioned Pain Modulation Differences in Central and Peripheral Burning Mouth Syndrome (BMS) Patients
Authors: Yang Guangju , Jin Jianqiu , Wang Kelun , Baad‐Hansen Lene , Liu Hongwei , Cao Ye , Xie Qiu‐Fei , Svensson Peter 
Published: November 2024

ABSTRACTAimTo evaluate conditioned pain modulation (CPM) in burning mouth syndrome (BMS) patients with different pain mechanisms.Materials and MethodsTwenty BMS patients (52.0 ± 6.8 years, 17 women and 3 men) and age‐ and gender‐matched 22 healthy controls were enrolled in this randomised controlled trial. The patients received an active lingual nerve block (lidocaine) and a placebo injection (saline) randomly with an interval of 1 week in a double‐blinded manner. Patients evaluated their pain intensity on a 0‐ to 10‐cm visual analogue scale (VAS) before and after each injection, with or without CPM. Based on the anaesthesia effect, BMS patients were divided into two groups with presumed different pain mechanisms; a ‘central subgroup (n = 11)’ with pain relief less than 1 cm and ‘peripheral subgroup (n = 9)’ with pain relief more than 1 cm on the VAS. Mechanical pain threshold (MPT) and wind‐up ratio (WUR) were investigated at two oral mucosa regions: the region with most intense symptoms and a control region for the patient group; tongue and buccal region for the control group. CPM was induced by immersing the left hand into cold water. A moderate level of pain (around five on the VAS) was obtained by adjusting the water temperature. MPT and WUR were measured twice for all the participants with and without CPM, which was analysed and presented as relative change in MPT and WUR. Differences between groups were analysed using two‐way ANOVA. Differences within group between tests were assessed by paired t‐test.ResultsAt baseline, there were no significant group differences for MPT or WUR between BMS patients and healthy controls (p ≥ 0.156). The mean bath temperature to evoke moderate pain for the BMS group was significantly lower than that for the healthy control group (8.9°C vs. 11.9°C, p = 0.003). The CPM evoked an inhibitory modulation in 18.2%–44.4% of BMS patients, while for the healthy group, the ratio was 68.2%–81.8%. Central BMS patients had smaller CPM effects than healthy participants at the painful site and control site, which indicated a decreased CPM function (p ≤ 0.034). Peripheral BMS patients had lower CPM effects than healthy participants only at the painful site (p = 0.037).ConclusionsThe present findings documented impairment of central nociceptive inhibition processing in BMS patients which was more extensive in central BMS than peripheral BMS. These findings add to the suggestion that BMS may a heterogeneous pain condition with at least two different phenotypes.
The ArabidopsisE3 ubiquitin ligase DOA10A promotes localization of abscisic acid (ABA) receptors to the membrane through mono‐ubiquitination in ABA signaling
Authors: Liu Cuixia , Li Qingliang , Shen Zhengwei , Xia Ran , Chen Qian , Li Xiao , Ding Yanglin , Yang Shuhua , Serino Giovanna , Xie Qi , Yu Feifei 
Published: November 2024

Summary
The endoplasmic reticulum‐associated degradation (ERAD) system eliminates misfolded and short‐lived proteins to maintain physiological homeostasis in the cell. We have previously reported that ERAD is involved in salt tolerance in Arabidopsis. Given the central role of the phytohormone abscisic acid (ABA) in plant stress responses, we sought to identify potential intersections between the ABA and the ERAD pathways in plant stress response.
By screening for the ABA response of a wide array of ERAD mutants, we isolated a gain‐of‐function mutant, doa10a‐1, which conferred ABA hypersensitivity to seedlings.
Genetic and biochemical assays showed that DOA10A is a functional E3 ubiquitin ligase which, by acting in concert with specific E2 enzymes, mediates mono‐ubiquitination of the ABA receptor, followed by their relocalization to the plasma membrane. This in turn leads to enhanced ABA perception.
In summary, we report here the identification of a novel RING‐type E3 ligase, DOA10A, which regulates ABA perception by affecting the localization and the activity of ABA receptors through their mono‐ubiquitination.