bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Human Ventromedial Prefrontal Cortex: Sulcal Morphology and Its Influence on Functional Organization
Authors: Lopez-Persem Alizée , Verhagen Lennart , Amiez Céline , Petrides Michael , Sallet Jérôme 
Published: March 2019

The ventromedial prefrontal cortex (vmPFC), which comprises several distinct cytoarchitectonic areas, is a key brain region supporting decision-making processes, and it has been shown to be one of the main hubs of the Default Mode Network, a network classically activated during resting state. We here examined the interindividual variability in the vmPFC sulcal morphology in 57 humans (37 females) and demonstrated that the presence/absence of the inferior rostral sulcus and the subgenual intralimbic sulcus influences significantly the sulcal organization of this region. Furthermore, the sulcal organization influences the location of the vmPFC peak of the Default Mode Network, demonstrating that the location of functional activity can be affected by local sulcal patterns. These results are critical for the investigation of the function of the vmPFC and show that taking into account the sulcal variability might be essential to guide the interpretation of neuroimaging studies.SIGNIFICANCE STATEMENTThe ventromedial prefrontal cortex (vmPFC) is one of the main hubs of the Default Mode Network and plays a central role in value coding and decision-making. The present study provides a complete description of the interindividual variability of anatomical morphology of this large portion of prefrontal cortex and its relation to functional organization. We have shown that two supplementary medial sulci predominantly determine the organization of the vmPFC, which in turn affects the location of the functional peak of activity in this region. Those results show that taking into account the variability in sulcal patterns might be essential to guide the interpretation of neuroimaging studies of the human brain and of the vmPFC in particular.
The Correlation between Physical Environmental Factors and the Occurrence of Leptospirosis
Authors: Kurniawati Ratna Dian , Nuryati Sri 
Published: March 2019

Leptospirosis is a disease caused by a bacteria called Leptospira. Environmental risk factors for leptospirosis include biological, social, and physical (river or bodies of water, ditches, puddles, and the distance between the settlement area with garbage disposal area).This research aimed to determine the correlation between the physical environmental factors with the evidence of leptospirosis in Sukahaji Village, Babakan Ciparay District of Bandung City in 2017. The design of this research is a survey with cross-sectional approach. We used 100 population samples in this research. The Technique of obtaining data with observation sheet is using sheet checklist. We did univariate and multivariate data analysis using Chi square.The results showed that most of the population experienced leptrospirosis, and most of the physical environment such as rivers or bodies of water, ditches, puddles, and the distance between settlement area with the garbage disposal area are the risk factors of leptospirosis.
La platería civil compostelana en el tránsito del siglo XIX al XX a través de las fotografías inéditas del archivo del platero Ricardo Martínez Costoya
Authors: Pérez Varela Ana 
Published: March 2019

Ricardo Martínez Costoya fue uno de los artífices más importantes de la Compostela del cambio del siglo XIX al XX, protagonizada por el efervescente contexto de reactivación de las peregrinaciones y la actividad artística tras la segunda inventio de los restos del Apóstol en 1879. El archivo personal que guardó el platero, compuesto por fotografías y bocetos, y hasta ahora inédito, reúne una valiosa muestra de piezas de platería, y resulta especialmente interesante para estudiar obras civiles, muy escasas en Galicia. El catálogo del artífice, con más de ciento cincuenta piezas y sesenta bocetos, constituye el conjunto más numeroso de obras conocidas de un platero gallego y demuestra un rico y variado eclecticismo que combina gran cantidad de estilos e influencias artísticas.
Šeimos ir darbo derinimo teisinės prielaidos Baltijos šalyse
Authors: Grigužauskaitė Snieguolė , Skučienė Daiva 
Published: March 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Viena iš pagrindinių piliečių gerovę užtikrinančių institucijų – šeima, kuri kaip socialinis vienetas veikia pagal tam tikras neformalias ir formalias taisykles. Viena iš visoje Europos Sąjungoje šeimos institutui aktualių problemų – šeimos ir darbo suderinimas, kuriai spręsti kuriama ir tobulinama teisinė bazė. Šiame straipsnyje siekiama atskleisti Baltijos šalyse suformuotas darbo sąlygų lengvatas, numatytas teisės aktuose ir skirtas šeimoms, auginančioms vaikus. Tyrimui naudojami įstatymų ir 2017 metų MISSOC duomenų bazės duomenys, kurie analizuojami temų analizės metodu, formuluojant jas remiantis įstatymų grupėmis. Tyrimo rezultatai atskleidė, kokioms teisinėms priemonėms skiriama daugiausia ir mažiausia dėmesio Baltijos šalyse, pvz., daugiausia dėmesio skiriama komandiruočių, maitinimo krūtimi pertraukų, atostogų garantavimo ir kt. teisiniam reglamentavimui.
The results of implementation of specialized stroke units and educational programs aimed at the secondary prevention of stroke in Tyumen district
Authors: Lebedeva D. I. , Brynza N. S. , Nyamtsu A. M. , Reshetnikova Yu. S. , Kniazheva N. N. , Akarachkova E. S. , Orlova A. S. 
Published: March 2019

Aim. To evaluate the main results of work of specialized stroke units and departments and implementation of educational campaigns on secondary stroke prevention in Tyumen district in 2011-2017.Material and methods. Work efficacy of specialized stroke units and departments in Tyumen district was evaluated according to standard measures (length of hospital stay, compliance with patient routing rules, timely diagnostic measures, frequency and efficacy of thrombolysis). The results of work of schools for stroke patients and their caregivers were evaluated using questionnaires distributed after the end of each educational program.Results. We demonstrated an improvement of main efficacy measures of stroke units and departments, with most of them reaching target values for Russian Federation. There was a high attendance of educational programs on secondary stroke prevention (8254 persons during the study period). A total of 2200 distributed questionnaires demonstrated a high level of satisfaction with the results of educational programs and the quality of education organization.Conclusion. Implementation of specialized stroke units in Tyumen district enabled an increase of the number of patients receiving systemic thrombolytic therapy, a decrease of mortality and an improvement of functional outcomes. Educational programs for stroke patients and their relatives increased the level of stroke awareness in the target population.
Staffing of outpatient departments of medical organizations by doctors of functional diagnostics in the Russian Federation, in 2012-2017
Authors: Tolmachev D. A. , Son I. M. , Ivanova M. A. , Popova N. M. 
Published: March 2019

Aim. To analyze the current situation in the staffing of functional diagnostics by doctors in the Russian Federation.Material and methods. The method of descriptive statistics was used to analyze the data of the Federal statistical observation № 30 “Information about the medical organization” on the staffing of doctors of functional diagnostics for the period from 2012 to 2017.Results. During the analyzed period, the staffing of doctors of functional diagnostics in the Russian was low, although there was a positive trend. In the calculation of staffing for the number of occupied positions in almost all Federal districts, parameter was higher than 80,0%, with the exception of the Southern Federal District (76,0%).Conclusion. The dynamics of the staffing parameter for the number of occupied positions was negative.
The use of telmisartan in patients with refractory arterial hypertension and obesity
Authors: Deneka I. Е. , Rodionov A. V. , Fomin V. V. 
Published: March 2019

Aim.To evaluate the effectiveness of telmisartan as a component of triple antihypertensive therapy in patients with obesity and refractory arterial hypertension.Material and methods.The study included 30 patients with obesity and refractory arterial hypertension. All patients received an angiotensin II receptor blocker (ARB) or an angiotensin-converting enzyme inhibitor (ACE inhibitor) in an adequate dosage as part of a triple antihypertensive therapy that also includes a calcium antagonist and thiazide diuretic. Participants were randomly divided into two equal groups. In the main group, telmisartan (Dr. Reddy’s Laboratories) was prescribed at a dosage of 80 mg/day instead of the previously taken ARB or ACE inhibitor. In the control group, patients continued to receive a previously prescribed ARB or an ACE inhibitor. The primary end point was a decrease in mean daily systolic and/or diastolic blood pressure (SBP and DBP) according to 24-hour blood pressure monitoring at 10 mm Hg and more than 20 weeks after the start of the study. The secondary end point was a decrease in the concentration of inflammatory markers and an increase in the level of adiponectin by 15%.Results.After 20 weeks, in the telmisartan group, we noted a significant decrease in the average daily SBP and DBP: in the main group from 145,9±5,4/95,6±4,8 mm Hg to 134,8±3,0/84,9±4,2 mm Hg, in the control group with 147,2±4,9/96,4±5,6 mm Hg to 142,4±4,3/96,9±62 mm Hg. We also determined an increase in the serum adiponectin concentration from 9,3±5,6 μg/ml to 13,4±6,6 μg/ml in the main group and a decrease from 8,8±5,2 μg/ml to 8,6±5,6 μg/ml in the control group, as well as a decrease in the concentration of highly sensitive C-reactive protein (main group from 8,8±3,0 to 6,0±2,8 mg/l and the control group from 7,4±3,8 to 6,9±4,9 mg/l) and interleukin-6 (main group from 16,2±6,1 to 12,3±2,8 pg/ml, control group from 22,5±4,2 to 19,9±5,2 pg/ml).Conclusion.Telmisartan can be considered as a drug of choice as part of multi-component therapy in the treatment of patients with obesity and refractor arterial hypertension.
Comparative characteristics of risk factors as predictors of coronary heart disease in women during an epidemiological and clinical examination
Authors: Kasumova F. N. , Faradzheva N. A. , Mamedova R. N. , Sultanova S. S. 
Published: March 2019

Aim. To analyze main risk factors (RF) according to the epidemiological and clinical study and to determine the predictors of the development of coronary artery disease (CAD) in women.Material and methods. The study included 200 women with CAD who were divided into 2 groups: I-epidemiological and II-clinical (99 and 101 patients respectively). For verification of CAD, patients were provided with a full range of epidemiological and clinical-instrumental studies.Results. It was shown that relative risk (RR) mean values (1-2) were in BMI, abdominal obesity, arterial hypertension, hypertriglyceridemia (HTG) and HDL-hypocholesterolemia. Its higher values are for hypercholesterolemia (RR=1,2), atherogenic index (RR=1,4) and LDL-hypercholesterolemia (RR=1,5). As for additional RF, the RR for estradiol was 1,2. The highest RR was for progesterone, reaching 3,5 and for testosterone — 2,8.Conclusion. We determined that if among the traditional RF there are no independent predictors of CAD, specialists in clinical practice can primarily use hormones (progesterone and testosterone).
Supply of vitamins for patients with type 2 diabetes and obesity in the autumn
Authors: Beketova N. A. , Kosheleva O. V. , Vrzhesinskaya O. A. , Kodentsova V. M. , Sharafetdinov H. H. , Plotnikova O. A. , Pilipenko V. V. , Alekseeva R. I. , Leonenko S. N. , Sokolnikov A. A. 
Published: March 2019

Aim. To assess the availability of patients with type 2 diabetes mellitus (DM-2) and obesity with vitamins C, A, E, D, B2, B6, niacin and betacarotene.Material and methods. We assess vitamin status of 40 patients with DM-2 (14 men and 26 women) aged 42-80 years was 60,2±1,3 (Me=60,5) with concomitant obesity and a body mass index from 31,2 to 57,4 kg 42,1±1,1 (Me=42,0), receiving oral hypoglycemic therapy. The disease duration ranged from six months to 32 years — 7,4±1,0 (Me=6,0), the level of glycohemoglobin — from 5,20% to 7,70% — 6,27±0,11 (Me=6,05). The provision of C, A, E, D, B2 vitamins and beta-carotene was assessed by their serum concentration, B6 and niacin vitamins — by excretion of their metabolites with urine.Results. Against the background of a good supply of patients with A, E, C and PP vitamins, a reduced serum concentration of 25-OH vitamin D was detected in the majority (83%) of the patients, beta carotene — in 55%, insufficient provision with vitamins B6 and B2 — 15-18%. A reduced serum concentration of 1-2 vitamins was detected in 65% of the patients. A combined deficiency of 3-4 vitamins had 25% of patients.Conclusion. The presence of vitamin deficiencies in patients with DM-2, which are a risk factor for its occurrence and the development of complications, indicates the need to optimize vitamin status. The negative association between the level of basal glycemia in venous blood and glucosuria and the concentration of γ-tocopherol may indicate certain benefits of using dietary oils with a high level of vitamer.
Evaluation of Miracle Mouthwash plus Hydrocortisone Versus Prednisolone Mouth Rinses as Prophylaxis for Everolimus-Associated Stomatitis: A Randomized Phase II Study
Authors: Jones Vicky E. , McIntyre Kristi J. , Paul Devchand , Wilks Sharon T. , Ondreyco Sharon M. , Sedlacek Scot , Melnyk Anton , Oommen Sanjay P. , Wang Yunfei , Peck Susan R. , O'Shaughnessy Joyce A. 
Published: March 2019

AbstractBackgroundMammalian target of rapamycin (mTOR) inhibitor-associated stomatitis (mIAS) is a frequent adverse event (AE) associated with mTOR inhibitor therapy and can impact treatment adherence. The objectives are to evaluate two steroid-based mouthrinses for preventing/ameliorating mIAS in patients with metastatic breast cancer (MBC) treated with everolimus.Materials and MethodsThis prospective, randomized phase II study enrolled 100 postmenopausal patients with hormone receptor-positive MBC within the US Oncology Network who were initiating therapy with an aromatase inhibitor + everolimus (AIE; 10 mg/day). Patients were randomized to prophylactic therapy with one of two oral rinses (Arm 1: Miracle Mouthwash [MMW] 480 mL recipe: 320 mL oral Benadryl [diphenhydramine; Johnson & Johnson, New Brunswick, NJ, USA], 2 g tetracycline, 80 mg hydrocortisone, 40 mL nystatin suspension, water; or Arm 2: prednisolone [P] 15 mg/5 mL oral solution, 1.8% alcohol). Patients were instructed to swish/expectorate 10 mL of the assigned rinse for 1–2 minutes four times daily starting with day 1 of AIE treatment, for the first 12 weeks.ResultsA total of 100 patients received treatment (49 MMW; 51 P). The incidence of stomatitis/oral AEs during the first 12 weeks was 35% (n = 17/49) and 37% (19/51) in the MMW and P arms, respectively. The incidence of grade 2 oral AEs was 14% (7/49) and 12% (6/51) with MMW or P, respectively. There were two grade 3 oral AEs (MMW arm) and no grade 4 events. There was one everolimus dose reduction (MMW) and six dose delays (four MMW, two P) and one dose reduction + delay (MMW) during the first 12 weeks of treatment. No patients stopped steroid mouthwash therapy because of rinse-related toxicity.ConclusionProphylactic use of steroid-containing oral rinses can prevent/ameliorate mIAS in patients with MBC treated with AIE. MMW + hydrocortisone is an affordable option, as is dexamethasone oral rinse.Implications for PracticeThis prospective phase-II study showed that two steroid-containing mouthrinses substantially reduced incidences of all-grade and grade ≥2 stomatitis and related oral adverse events (AEs), and the number of everolimus dose-delays and/or dose-reduction in metastatic breast cancer (MBC) patients receiving everolimus treatment plus an aromatase inhibitor. Both oral rinses were well tolerated and demonstrated similar efficacy. Prophylactic use of steroid mouth rinse provides a cost-effective option that substantially decreases the incidence and severity of mammalian target of rapamycin (mTOR) inhibitor-associated stomatitis and related oral AEs as well as the need for dose modification in MBC patients undergoing treatment with an mTOR inhibitor.
Death-related expressions in Javanese angkating layon speech and English eulogy
Authors: Munandar Aris 
Published: March 2019

Cultures hold different perceptions of death and demonstrate different linguistic behaviors when performing funeral rituals. This article compares angkating layon speech in Javanese society and eulogies in American society focusing on the use of death-related expressions to reveal their rhetorical function and significance in articulating the two societies’ perception toward death. The data are collected from ten angkating layon speech texts recorded from actual funeral ceremonies and ten eulogy texts downloaded from the internet. Conceptually, this article applies Kunkel's and Dennis's (2003) idea of eulogical rhetoric and Lakoff's andJohnson's (1980) theory of conceptual metaphor. The findings show that both societies conceptualize death into DEATH IS A JOURNEY and DEATH IS REST. Angkating layon speech is an allusion for sincere acceptance of death, uses less elaborate positive euphemism as a brief report of the deceased’s good characters, and evokes empathy and sincere prayer for the deceased. Meanwhile, a eulogy is a means of maintaining togetherness between the dead and the living, uses elaborate positive euphemism to create a good impression of the eulogized, and thus, appeals more strongly to the memory of the living. It concludes that the Javanese are open about the dead body, create such euphemisms as almarhum(ah), layon/jenazah, and swargito mark the dead as 'other' suggesting that he/she is no longer part of the society, and readily accept a permanent separation from the dead. On the contrary, Americans are reluctant to mention the dead body, deny separation from the dead, and use almost non-existent lexical marker 'late' signifying death as another episode of life that never affects their relationship with the deceased.
PENGARUH KONSERVATISME TERHADAP ASIMETRI INFORMASI (STUDI EMPIRIS PADA PERUSAHAAN MANUFAKTUR DI BEI)
Authors: Yulia Aida 
Published: March 2019

The purpose of this study was to determine the effect of accounting conservatism on information asymmetry in the annual reports of companies listed on the Indonesia Stock Exchange.Target population in this study is a manufacturing company listed on the Indonesia Stock Exchange (BEI) with year observations from 2009 to 2011 the number of companies by 23 companies.Of accounting conservatism measurements conducted on 23 companies, the population of the obtained results of all companies that meet more than one measurement assumptions of accounting conservatism with market value to book value ratio greater than 1, so that the company can be classified as a conservative company. From the test results it can be concluded that the regression coefficient of determinant (R2) value 0.240 indicates that accounting conservatism is able to affect the asymmetry of information in the annual reports of companies listed on the Indonesia Stock Exchange amounted to 24.0 percent and the remaining 76.0 percent is influenced by other variables outside of the research model. Piecemeal evidence suggests that accounting conservatism variable regression coefficient of -0.474, (β ≠ 0), meaning that in partial accounting conservatism and significant negative effect of the information asymmetry in the annual reports of companies listed on the Indonesia Stock Exchange. Refers to the requirement that the results of the study reject Ho and accept Ha. Keywords: Accounting Conservatism and Information Asymmetry
PENGARUH KECERDASAN EMOSIONAL DAN MINAT BELAJAR TERHADAP PRESTASI BELAJAR (KASUS PADA MAHASISWA PENDIDIKAN AKUNTANSI UNIVERSITAS PENDIDIKAN INDONESIA BANDUNG)
Authors: Wahyuni Shinta 
Published: March 2019

Penelitian ini bertujuan untuk mengetahui pengaruh kecerdasan emosional dan minat belajar terhadap prestasi belajar mahasiswa Pendidikan Akuntansi UPI Bandung. Penelitian ini menggunakan metode survey dengan desain penelitian korelasional. Pengumpulan data dilakukan dengan menggunakan angket yang telah diuji validitas dan reliabilitasnya. Data diolah dengan menggunakan statistik parametrik dengan teknik analisis regresi multiple. Penarikan kesimpulan hasil penelitian menggunakan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa kecerdasan emosional dan minat belajar memiliki pengaruh positif terhadap prestasi belajar mahasiswa. Implikasi dari hasil penelitian yang disarankan peneliti adalah bahwa para mahasiswa harus dapat lebih mengendalikan emosinya dan lebih mandiri dalam belajar untuk memperoleh prestasi belajar yang lebih baik. Kata Kunci : Kecerdasan Emosional, Minat Belajar, Prestasi Belajar, Indeks Prestasi Kumulatif (IPK)
PENGARUH PENGGUNAAN MEDIA PEMBELAJARAN TERHADAP MOTIVASI BELAJAR SISWA PADA MATA PELAJARAN AKUNTANSI
Authors: Mulyadi Ajang 
Published: March 2019

Penelitian ini berawal dari sebuah fenomena yang terjadi di SMA Negeri 18 Bandung, dimana motivasi belajar siswa pada mata pelajaran Akuntansi bisa dikatakan rendah. Hal ini ditunjukkan oleh sebuah data awal berupa data absensi siswa kelas XI IPS pada mata pelajaran Akuntansi. Terdapat banyak hal yang dapat mempengaruhi motivasi belajar siswa. Dalam penelitian ini, peneliti berfokus pada salah satu faktor yang mempengaruhi motivasi belajar, yaitu penggunaan media pembelajaran. Penelitian ini bertujuan untuk mengetahui gambaran mengenai penggunaan media pembelajaran dan motivasi belajar siswa kelas XII IPS di SMA Negeri 18 Bandung. Selain itu, penelitian ini juga bertujuan untuk mengetahui bagaimana pengaruh penggunaan media pembelajaran terhadap motivasi belajar siswa kelas XII IPS di SMA Negeri 18 Bandung. Metode yang digunakan pada penelitian ini adalah metode survey verifikatif. Populasi dalam penelitian ini adalah siswa kelas XII IPS sebanyak 140 siswa. Sampel yang diambil sebanyak 104 siswa. Teknik pengambilan sampel yang digunakan adalah teknik simple random sampling. Data mengenai penggunaan media pembelajaran dan motivasi belajar siswa didapatkan dengan menyebarkan angket. Pengujian statistik yang digunakan dalam penelitian ini, yaitu uji normalitas data, uji linieritas, analisis korelasi, uji determinasi dan uji signifikansi. Perhitungan statistik tersebut dibantu dengan software SPSS v.16 for Windows. Gambaran penggunaan media pembelajaran berdasarkan persepsi siswa berada pada kategori cukup, yaitu sebesar 65,38%. Sedangkan motivasi belajar siswa menurut persepsi siswa berada pada kategori cukup pula dengan nilai sebesar 58,65%. Hasil penelitian menunjukkan bahwa penggunaan media pembelajaran berpengaruh positif terhadap motivasi belajar siswa pada mata pelajaran Akuntansi. Hasil penelitian ini telah diuji dan diterima kebenarannya dengan tingkat kepercayaan 95%. Hal ini dibuktikan dengan nilai korelasi sebesar 0,453 dan koefisien determinasi sebesar 0,205. Hal ini berarti bahwa penggunaan media pembelajaran mempengaruhi motivasi belajar siswa pada mata pelajaran Akuntansi sebesar 20,5%. Sedangkan sisanya sebesar 79,5% dipengaruhi oleh faktor lainnya. Kata Kunci : Penggunaan Media Pembelajaran, Motivasi Belajar Siswa