bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Phase II Trial of Selinexor (KPT-330) for Metastatic Triple-Negative Breast Cancer
Authors: Shafique Michael , Ismail-Khan Roohi , Extermann Martine , Sullivan Dan , Goodridge Dawn , Boulware David , Hogue Deanna , Soliman Hatem , Khong Hung , Han Hyo S. 
Published: April 2019

Abstract

Lessons Learned
Single-agent selinexor has limited activity in heavily pretreated patients with metastatic triple-negative breast cancer. Selinexor 60 mg by mouth twice weekly was generally well tolerated with a side-effect profile consistent with previous clinical trials. Future studies of selinexor in this population should focus on combination approaches and a biomarker-driven strategy to identify patients most likely to benefit.

Background
This phase II trial evaluated the safety, pharmacodynamics, and efficacy of selinexor (KPT-330), an oral selective inhibitor of nuclear export (SINE) in patients with advanced triple-negative breast cancer (TNBC).

Methods
This phase II trial was designed to enroll 30 patients with metastatic TNBC. Selinexor was given at 60 mg orally twice weekly on days 1 and 3 of each week, three of each 4-week cycle. The primary objective of this study was to determine the clinical benefit rate (CBR), defined as complete response + partial response + stable disease (SD) ≥12 weeks.

Results
Ten patients with a median age of 60 years (range 44–71 years) were enrolled between July 2015 and January 2016. The median number of prior chemotherapy lines was 2 (range 1–5). A planned interim analysis for the first stage per protocol was performed. Three patients had SD and seven had progressive disease. On the basis of these results and predefined stoppage rules, the study was halted.

Conclusion
Selinexor was fairly well tolerated in patients with advanced TNBC but did not result in objective responses. However, clinical benefit rate was 30%, and further investigation of selinexor in this patient population should focus on combination therapies.
KAJIAN SUMBER ENERGI PADA PENGOLAHAN KELAPA SAWIT MENJADI CRUDE PALM OIL (CPO) DI PT. ALNO AGRO UTAMA SUMINDO OIL MILL, BENGKULU UTARA
Authors: Hidayat Lukman , Surawan Fitri Electrika Dewi , Raja Arga Harianda Lumban 
Published: April 2019

Increasing demand for Crude Palm Oil (CPO) as the vegetable oil was causing the industry to cultivate palm oil increased, so that the energy required to produce CPO also increased. The purpose of this study is to identify the type, source and calculate the amount of energy needs, calculate the level of efficiency and energy savings opportunities. Stages of the research are initial energy analysis, a detailed energy, and energy analysis in processing systems. Based on the research results, to produce each kg of CPO processing capacity of 60 ton TBS / hour with a recovery rate of 20.59% of primary energy needs of 16.200679 MJ / kg. Real boiler efficiency of 45.69%, the real efficiency of the turbine was 94, 86%. Turbine efficiency to generate electrical energy by 1.09%, the technical efficiency of 66.80% turbines, diesel generators technical efficiency of 47.25%, the technical efficiency of electric motors by 59.37%. The total efficiency of electricity use by 4,75%, the efficiency of diesel estate of 1.379% and the efficiency of the use of steam at 93.77%. Energy can be saved by 0.0442 MJ / kg with a description of human powered energy of 0.0004316 MJ / kg, energy electrical energy by .04372 MJ / kg. While energy can be stored on the excess energy to fuel biomass boiler was 1.45 MJ / kg
Species distribution of yeasts recovered from different clinical samples Addiss Ababa,Ethiopia
Authors: Deribe Elias Seyoum , Bitew Adane , Mihret Amete 
Published: April 2019

Abstract
Background
Currently, fungal diseases of humans are among the most problematic illnesses is the result of an increase in opportunistic fungal infections caused by rise in the number of immune-compromised patients. Particularly, yeasts are the most common cause of fungal infections leading to a range superficial type to life-threatening invasive infections. The aim of this study is to determine species distribution of yeasts particularly of Candida species recovered from different clinical samples.

Method
A cross sectional study was conducted from January 01, 2018 –September 30, 2018 in Addis Ababa, Arsho laboratory. Oropharengial swabs, nail scrapings, sputum, corneal scrapings, and vaginal swabs were collected from patients with signs and symptoms of infections. Identification and antifungal susceptibility testing was performed by using YST card through VITEK 2 compact system. Data was entered and analyzed using SPSS version 20.

Result
A total of 209 yeasts were recovered of which 49.8% were Candida albicans, 43.1% were non-albicans candida species and 7.2% were yeasts other than Candida species. The current study, eighteen (18) different types of yeast species were identified from different clinical samples. All recognized yeast considered as a causative agent of fungal infection in previously reported data in worldwide.

Conclusion
C. albicans remaining the predominant species, but the emergence of non-albicans Candida and other than candida species have increased. Thus, more studies on Candida prevalence are needed throughout country.
Predictors to HIV testing among youth women in Ethiopia: 2016 Ethiopian Demographic and Health Survey
Authors: Diress Gedefaw , Ahmed Mohammed , Adane Seteamlak , Linger Melese , Aleminew Birhan 
Published: April 2019

Abstract
Background

HIV testing is the critical first step in identifying and linking HIV infected people to the treatment cascade and it also provides an important opportunity to reinforce HIV prevention among the negatives. The aim of this study was examine factors associated with HIV testing among youth women.

Methods

A community-based cross-sectional study design was used and a nationally representative secondary data analysis was done on the 2016 Ethiopian Demographic and Health Survey(EDHS). A total of 6401 youth women were eligible in the study. The data were analyzed by SPSS version 20. Frequencies and weighted percentage of the variables were calculated. Chi-square tests and logistic regression models were used to assess predictors of HIV testing. Multivariate logistic regression analysis was conducted to control confounders and to identify the independent contribution of each variable to the outcome variable.

Result

A total of 6401 youth women aged 15 to 24 years of age were included. Only 37.7% (95% CI:(33.6-39.1%)) of participants were ever tested for HIV in their life. In the final multivariable model age, marital status, level of educational, media access, number of sexual partner, STIs in Past 12 months and comprehensive knowledge to HIV, were significantly associated with ever been tested for HIV. Youth women who were in the age group between 20 to 24 (AOR=2.18; 95CI:(1.800-2.652), who were married (AOR=4.70; 95% CI:(3.674-6.008)), were divorced (AOR=6.16; 95% CI (3.976-9.541)), who had no access to media (AOR = 0.69; 95 CI %: (0.540-0.870)), who had no comprehensive HIV knowledge (AOR = 0.68; 65% CI: (0.530-0.861)) and having one or more sexual partners (AOR=2.48; 95% CI:(1.350-4.551)) were significantly associated with ever been tested for HIV.
The Progressive Journey of Phytosomes in Herbal Based Pharmacotherapeutics
Authors: Mahapatra Debarshi K. , Patil Shailendra , Patil Asmita G. 
Published: April 2019

Background:
The primary objective of any pharmacotherapeutics approach entirely lies with
the effectiveness of the rationally designed delivery system to effectually deliver the suitable drug at the
appropriate concentration at the proper site. Phytosomes are most effective carrier for the possible enhancement
of bioavailability, reduction in the clearance rate, providing higher dissolution, and amplification
of solubility by several folds of various natural products.

Methods:
The present review article focuses exclusively on the recent global advancements in the
emerging novel drug delivery field of phytosomes from the year 1996 to present.

Results:
The article comprehensively highlights the reported phospholipid complexes of the active phytoconstituents
(18β-Glycyrrhetinic acid, Andrographolide, Baicalein, Baicalin, Berberine, Catechin,
Celastrol, Curcumin, Epigallocatechin-3-O-gallate, Evodiamine, Gingerol, Gymnemic acid, Icaritin,
Kaempferol, L-carnosine, Luteolin, Mitomycin-C, Piperine, Quercetin, Resveratrol, Rutin, Salicin,
Silibinin or Silybin or Silymarin, Sinigrin, and Umbelliferone) and herbal extracts (Aegle marmelos,
Allium cepa, Allium sativum, Bacopa monnieri, Boswellia serrata, Butea monosperma, Calendula officinalis,
Centella asiatica, Citrullus colocynthis, Ginkgo biloba, Glycine max, Lawsonia inermis, Mentha
pulegium, Momordica balsamina, Momordica dioica, Phyllanthus amarus, Phyllanthus emblica, Tecomella
undulate, and Woodfordia fruticosa) in treatment of various ailments along with the possible
enhancement of pharmacodynamics and pharmacokinetic attributes. The review also exhaustively focuses
on the clinical trials of several vesicular products and patents information.

Conclusion:
This article will be vital for the researchers of numerous fields who are working towards
the development of novel drug delivery system for translating better therapeutic effects of herbal based
components.
Selection of a Single Chain Variable Fragment Antibody (scFv) against Subtilisin BRC and its Interaction with Subtilisin BRC
Authors: Kim Chol-Jin , Choe Sunll , Ri Kum-Chol , Kim Chol-Ho , Li Hyon-Gwang , Yun Un-Hui 
Published: April 2019

Background:
The focus of this study was the selection of a single chain variable fragment
antibody (scFv) against subtilisin BRC, a fibrinolytic enzyme using phage display, and to characterize
the interaction between the antibody and subtilisin BRC.

Methods:
The subtilisin BRC-specific phage clones were selected using Griffin.1 scFv phage library
and sequenced. The gene of subtilisin BRC-specific scFv (scFv-BRC) from selected phage clone was
expressed in E. coli and scFv-BRC was characterized. Molecular modeling of the three-dimensional
(3D) structures of scFv-BRC was performed using MODELLER 9.19 modeling software and assessed
by PROCHEK. Molecular docking of subtilisin BRC with scFv-BRC was carried out using PATCHDOCK.

Results:
The size of scFv-BRC gene is 635bp and it consists of 54bp of heavy chain region (VH),
336bp of light chain region (VL), 45bp of a linker. scFv-BRC was actively expressed by E. coli expression
vector pET28a-scFv in E. coli BL21 (DE3), and the amount of expressed scFv-BRC was
about 50 mg/L. Its molecular weight is ~26kDa. The CDR domain of scFv-BRC consists of 6 amino
acids in CDR L1, 3 amino acids in CDR L2 and 9 amino acids in CDR L3. Docking results of subtilisin
BRC and scFv-BRC showed global energy of - 56.29 kJ/mol. Furthermore, the results showed that
amino acid residues in subtilisin BRC for binding with scFv-BRC are Tyr6, Ser182, Ser204, and
Gln206.

Conclusion:
scFv against subtilisin BRC selected using phage display showed relatively strong binding
energy with subtilisin BRC. The amino acid residues in subtilisin BRC for binding with scFv-BRC
are not relevant to that in subtilisin BRC for binding with its substrates. These results suggested that
scFv-BRC can be used as a ligand for detection and affinity purification of subtilisin BRC.
Sustitución esofágica por tubo gástrico invertido a raíz de estenosis esofágica por ingesta de cáusticos (presentación de caso). Hospital Infantil Robert Reid Cabral (HIRRC), República Dominicana
Authors: Cabrera Valerio Carlos , Alcántara Elvyn , Moreno Reyes Andreína , García Risk Ariadna L. , Quiroz Fernández Melissa L. 
Published: April 2019

Introducción: la lesión esofágica por cáusticos debida a la ingestión de álcalis o, con menos frecuencia, ácidos, puede ser accidental en niños o por intento de suicidio en adolescentes y adultos. La secuela esofágica de la ingestión de un cáustico es una cicatriz en la pared del esófago que se relaciona con frecuencia con la formación de estenosis intensa y en muchas ocasiones, se requiere de un conducto que restablezca la función del esófago.
Material y método: en el siguiente trabajo se expone el caso clínico de un paciente masculino de 7 años de edad, presentando sialorrea y dificultad para la deglución debido a ingesta de sustancia cáustica de manera accidental. Se realizó endoscopia que reporta estenosis esofágica de 2 mm, para garantizar su alimentación se le practicó una gastrostomía. No fue posible el esquema de dilatación, con la necesidad de proceder a una sustitución esofágica por tubo gástrico invertido vía retroesternal. Presentó una complicación postquirúrgica de neumotórax. Una estancia de 12 días con inicio de la vía oral a los 11 días de postquirúrgico, previa realización de esofagograma.
Conclusión el propósito consiste en describir la presentación y el progreso clínico del paciente luego de esta técnica de sustitución esofágica por tubo gástrico invertido vía retroesternal.
Evaluation of spent fuel transport cask from the radiological point of view
Authors: Abdelhady A. 
Published: April 2019

Abstract
As a perspective plan to transport the spent fuel of material testing of research reactor (MTR) from the temporary storage to permanent storage, choosing an adequate cask is very important to ensure the safety precautions during the transport process. Latin America cask is one of the transportation cask types may be chosen to transport the spent fuel elements where it was designed to transport the irradiated fuel for MTR and the TRIGA research reactors. Therefore, it must be evaluated from the neutronic, radiological, and thermal points of view. The cask has internal diameter of 60 cm which make it possible to content 21 of spent fuel elements of MTR. This study aims to evaluate dose rate distribution around the cask after loading with 21 of MTR spent fuel elements which have been stored for 5-years as a minimal decay time in the temporary storage. For this, MCNP5 code was used to determine the dose rate in the radial and axial directions around the cask. The results show that the dose rates at the cask surface and at 200 cm from the surface are lower than the permissible transportation limits.
Naloxone Ameliorates Spatial Memory Deficits and Hyperthermia Induced by a Neurotoxic Methamphetamine Regimen in Male Rats
Authors: Khalifeh Solmaz , Khodamoradi Mehdi , Hajali Vahid , Ghazvini Hamed , Eliasy Lelia , Kheradmand Afshin , Farnia Vahid , Akhtari Javad , Shahveisi Kaveh , Ghalehnoei Hossein 
Published: April 2019

Background: Methamphetamine (METH) as a synthetic psychostimulant is being increasingly recognized as a worldwide problem, which may induce memory impairment. On the other hand, it is well established that naloxone, an opiate antagonist, has some beneficial effects on learning and memory. The present research aimed at evaluating naloxone effects on spatial learning and memory impairment triggered by a neurotoxic regimen of METH in male rats. Materials and Methods: The animals received the subcutaneous (sc) regimen of METH (4×6 mg/kg at 2-h intervals), intraperitoneal (ip) naloxone (4×1 mg/kg at 2-h intervals), or normal saline at four events. The Nal-METH group of rats received four naloxone injections (1 mg/kg, ip) 30 min before each METH injection (6 mg/kg, sc) at 2-h intervals. Seven days later, they were evaluated for spatial learning and memory in the Morris Water Maze (MWM) task. Result: METH regimen induced hyperthermia, as well as a poor performance, in the acquisition and retention phases of the task, indicating spatial learning and memory impairment compared to the controls. Naloxone administration (1 mg/kg, ip) before each METH injection led to significant attenuations of both hyperthermia and METH adverse effects on the rat performance in the MWM task. Conclusion: The results revealed that pretreatment with the opiate antagonist naloxone could prevent METH adverse effects on body temperature and memory performance. It seems that the opioidergic system and hyperthermia may, at least partially, be involved in METH effects on spatial memory. [GMJ. 2019;8:e1182]
Vocal Acoustic Measures of Asymptomatic Filipino Young Adults at a Private Tertiary Hospital in Quezon City – A Pilot Study
Authors: Delovino Kirt Areis E. , Casile Ray U. , Hawson Frederick Y. 
Published: April 2019

Objective: To describe the vocal acoustic measures of nonsmoking Filipino young adults without voice complaints at a private tertiary hospital in Quezon City; to determine if our baseline values are distributed normally and comparable to data in similar studies done abroad; and to recommend normative voice parameters which may be used as baseline data in our institution and for comparison in future studies.
Methods:
Design: Cross-sectional study
Setting: Private tertiary hospital
Participants: A total of 70 subjects were recruited at random.
Results: Values extracted for f0, Jitter %, Jitter dB, Shimmer %, Shimmer dB and NHR showed normal distribution of results. The average vocal acoustic values found in the present study for male voices producing the vowel /a/ were fo = 130.6 ± 13.65Hz, jitter = 0.0.46 % ± 0.184, jitter dB: 37.62dB ± 16.664, shimmer %= 0.23%, shimmer dB=0.23 ± 0.67 and NHR = 0.13 ± 0.010. The average values found for female voices, producing the vowel /a/ were fo = 218.38 ± 26.192Hz, jitter = 0.87% ± 0.61, jitter dB: 34.82 ± 22.5, shimmer %= 2.72 ± 1.07 shimmer dB=0.23db ± 0.67 and NHR = 0.12dB ± 0.016. Values retrieved from this study show similar trends with other papers abroad.
Conclusions: Voice acoustic systems are composed of different recording criteria, recording instrumentations and algorithms which primarily cause the differences in the results obtained in various studies, thus precluding a single normalization. Following international recommendations for individual normalization per institution, we have obtained our own values. Our data was comparable to the results of other international studies. However further investigation is recommended in areas where possibilities of interdialectic variation may produce an effect on the outcome of the study.
Keywords: vocal acoustic measures, computerized speech lab, normative voice parameters
Pyriform Sinus Fistula
Authors: Bickle Ian C. 
Published: April 2019

This 17-year-old young man attended the oromaxillofacial (OMF) department of a tertiary surgical center. He had attended both local and overseas ENT departments since the age of 5 years. Previous, but unspecified surgery had been performed as a child, with ongoing problems, since with a discharging sinus on the anterior aspect of the lower left side of the neck.
On clinical examination, several scars were present on the anterior aspect of the neck, and a skin opening was evident in the left para-midline of the lower neck.
Following clinico-radiological discussion a barium swallow was undertaken (Figures 1 and 2).

Discussion
A pyriform sinus fistula is an uncommon, but well documented condition. It is most commonly observed in the pediatric community, usually presenting with an acute neck infection.
The vast majority occur on the left side of the neck, with reports documenting fistula on this side accounting for between 83 and 100%.1, 2 It is highly associated with an underlying congenital 3rd or 4th branchial cyst.
Various imaging modalities have been employed in the identification and characterization of a pyriform sinus fistula. Barium swallow has been traditionally used and may elegantly illustrate the fistula in a dynamic fashion. However, the tract is not always well demonstrated. Use of a cross sectional modality (ideally MRI) is essential in identifying; the fistula and its course, any underlying branchial cyst, an associated acute neck infection and whether the thyroid gland is involved.3 Thyroid gland involvement is frequently encountered given the typical course of the fistula.4
Fiberoptic endoscopy is also employed to identify the origin of the fistula in the pyriform sinus and is an important part of the diagnostic process.
Definitive treatment is complete excision of the fistula and any underlying cystic focus. Alternative methods have been employed with success, including chemo-cauterization and the use of fibrin to close the fistulous tract.5
Rosai-Dorfman Disease Presenting as Recurrent Nasal Polyposis
Authors: Apale Neil Louis L. , Romualdez Joel A. , Rivera Rodolfo E. 
Published: April 2019

Objective: To present a case of Rosai-Dorfman disease in an individual with a 14-year history of recurrent nasal polyposis, and discuss its clinical presentation, physical examination, radiologic findings, histopathologic characteristics, and available treatment.
Methods:
Design: Case Report
Setting: Tertiary Private Hospital
Patient: One
Result: A 26-year-old Filipino diagnosed and repeatedly treated medically and surgically for recurrent nasal polyposis underwent repeat endoscopic sinus surgery. A histopathologic impression of Rosai-Dorfman disease was confirmed by positive S-100 and CD1a negative immunochemistry in conjunction with the morphologic findings.
Conclusion: Rosai-Dorfman disease is a rare entity which should be considered when dealing with recurrent nasal polyposis that is intractable to initial medical and surgical therapies. Histopathologic findings of emperipolesis and immunohistochemical S-100 stains play a key role in the diagnosis, but there is yet no definite treatment for this disease.
Keywords: recurrent nasal polyposis, Rosai-Dorfman disease, emperipolesis, S-100 stain
Diagnostic Value of Computerized Dynamic Posturography in the Assessment of Peripheral Vestibular Disorders
Authors: Soriano Ronaldo G. , David Reylan B. , Martinez Norberto V. 
Published: April 2019

Objective: This study aims to determine the sensitivity, specificity, positive predictive value and negative predictive value of Computerized Dynamic Posturography (CDP) in properly labeling patients with peripheral vestibular disorders by Videonystagmography (VNG) as having vestibular dysfunction.
Methods:
Study Design: Case - Control Study
Setting: Tertiary Private Hospital
Subjects: Twenty-three (23) patients aged 18 and above, with no history of hypertension or cardiovascular disease and no intake of anti-vertigo medications for at least 48 hours prior to testing, and with complete VNG and CDP results obtained on the same day or at least two days apart were included in the study. Cases were defined as those diagnosed with a peripheral vestibular disorder by VNG while controls were defined as those with normal VNG results. Sensitivity, specificity, positive predictive value and negative predictive value of CDP in labeling those with peripheral vestibular disorders as vestibular were determined using VNG as gold standard.
Results: There were 11 cases (4 males, 7 females) and 12 controls (8 males, 4 females). Using VNG as the gold standard for diagnosing peripheral vestibular disorders, CDP had a sensitivity of 45.45% and specificity of 66.67% with Positive Predictive Value(PPV) of 55.56% and Negative Predictive Value(NPV) of 57.14% in assessing peripheral vestibular disorders among the adults tested. Interestingly, 33.33% of patients with normal VNG may actually have had a vestibular dysfunction that could be detected by CDP.
Conclusion:
Prospective studies with larger sample sizes utilizing VNG and CDP are recommended in order to verify our findings.
Keywords: dizziness, posturography, vertigo