bluuebunny/crossref_metadata_2025_split huggingface dataset:
IKZF1plusDefines a New Minimal Residual Disease–Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia
Authors: Stanulla Martin , Dagdan Elif , Zaliova Marketa , Möricke Anja , Palmi Chiara , Cazzaniga Giovanni , Eckert Cornelia , te Kronnie Geertruy , Bourquin Jean-Pierre , Bornhauser Beat , Koehler Rolf , Bartram Claus R. , Ludwig Wolf-Dieter , Bleckmann Kirsten , Groeneveld-Krentz Stefanie , Schewe Denis , Junk Stefanie V. , Hinze Laura , Klein Norman , Kratz Christian P. , Biondi Andrea , Borkhardt Arndt , Kulozik Andreas , Muckenthaler Martina U. , Basso Giuseppe , Valsecchi Maria Grazia , Izraeli Shai , Petersen Britt-Sabina , Franke Andre , Dörge Petra , Steinemann Doris , Haas Oskar A. , Panzer-Grümayer Renate , Cavé Hélène , Houlston Richard S. , Cario Gunnar , Schrappe Martin , Zimmermann Martin ,   for the TRANSCALL Consortium,   the International BFM Study Group
Published: March 2018

PurposeSomatic deletions that affect the lymphoid transcription factor–coding gene IKZF1 have previously been reported as independently associated with a poor prognosis in pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL). We have now refined the prognostic strength of IKZF1 deletions by analyzing the effect of co-occurring deletions.Patients and MethodsThe analysis involved 991 patients with BCP ALL treated in the Associazione Italiana Ematologia ed Oncologia Pediatrica–Berlin-Frankfurt-Muenster (AIEOP-BFM) ALL 2000 trial with complete information for copy number alterations of IKZF1, PAX5, ETV6, RB1, BTG1, EBF1, CDKN2A, CDKN2B, Xp22.33/Yp11.31 (PAR1 region; CRLF2, CSF2RA, and IL3RA), and ERG; replication of findings involved 417 patients from the same trial.ResultsIKZF1 deletions that co-occurred with deletions in CDKN2A, CDKN2B, PAX5, or PAR1 in the absence of ERG deletion conferred the worst outcome and, consequently, were grouped as IKZF1plus. The IKZF1plusgroup comprised 6% of patients with BCP ALL, with a 5-year event-free survival of 53 ± 6% compared with 79 ± 5% in patients with IKZF1 deletion who did not fulfill the IKZF1plusdefinition and 87 ± 1% in patients who lacked an IKZF1 deletion ( P ≤ .001). Respective 5-year cumulative relapse incidence rates were 44 ± 6%, 11 ± 4%, and 10 ± 1% ( P ≤ .001). Results were confirmed in the replication cohort, and multivariable analyses demonstrated independence of IKZF1plus. The IKZF1plusprognostic effect differed dramatically in analyses stratified by minimal residual disease (MRD) levels after induction treatment: 5-year event-free survival for MRD standard-risk IKZF1pluspatients was 94 ± 5% versus 40 ± 10% in MRD intermediate- and 30 ± 14% in high-risk IKZF1pluspatients ( P ≤ .001). Corresponding 5-year cumulative incidence of relapse rates were 6 ± 6%, 60 ± 10%, and 60 ± 17% ( P ≤ .001).ConclusionIKZF1plusdescribes a new MRD-dependent very-poor prognostic profile in BCP ALL. Because current AIEOP-BFM treatment is largely ineffective for MRD-positive IKZF1pluspatients, new experimental treatment approaches will be evaluated in our upcoming trial AIEOP-BFM ALL 2017.
Multiparametric MR imaging of peripheral zone prostate cancer: effect of postbiopsy hemorrhage on cancer detection according to Gleason score and tumour volume
Authors: Jung Sung Il , Jeon Hae Jeong , Park Hee Sun , Yu Mi Hye , Kim Young Jun , Lee Seung Eun , Lim So Dug 
Published: March 2018

Objective:
To evaluate effect of postbiopsy hemorrhage on detection of peripheral zone (PZ) prostate cancer by multiparametric MR imaging according to Gleason score and tumor volume.

Methods:
This retrospective study included 54 biopsy-proven prostate cancer patients (median age, 67.0 years) who underwent multiparametric MR imaging. Two independent readers evaluated each sextant of the PZ using the PI-RADS v2. One reader recorded the presence or absence of hemorrhage per sextant on T 1 weighted MR images. Areas under the receiver operating characteristic curves (AUCs) were used to evaluate cancer detection accuracy.

Results:
Postbiopsy hemorrhage was noted in 122 (37.7%) of 324 sextants of all patients. There was no significant difference in the AUC for detection of cancer with Gleason score ≥3 + 4 or volume ≥0.5 ml between sextants with and without hemorrhage (with hemorrhage, reader 1, 0.83 for Gleason score ≥3 + 4, 0.84 for tumor volume ≥0.5 ml; reader 2, 0.74 for Gleason score ≥3 + 4, 0.77 for tumor volume ≥0.5 ml; without hemorrhage, reader 1, 0.86 for Gleason score ≥3 + 4, 0.88 for tumor volume ≥0.5 ml; reader 2, 0.79 for Gleason score ≥3 + 4, 0.83 for tumor volume ≥0.5 ml; p &gt; 0.2 for all).

Conclusion:
Postbiopsy hemorrhage did not negatively affect the detection of clinically significant PZ prostate cancer on multiparametric MR imaging.

Advances in knowledge:
Under influence of postbiopsy hemorrhage, multiparametric MR can be useful for the detection of clinically significant PZ prostate cancer.
Kulturwissenschaftliche Ansätze am Beispiel der griechischen Germanistik
Authors: BLIOUMI AGLAIA 
Published: March 2018

Der Themenschwerpunkt des Bandes fördert geradezu auf, die Gegenüberstellung zwischen Inlands- und Auslandsgermanistik zu sichten und dabei auf den Zusammenhang zwischen Theorie und Praxis einzugehen, bzw. neuere Entwicklungen, wie jener kulturwissenschaftlichen Lehre, unter die Lupe zu nehmen. Zweifelsohne gilt die Hauptunterscheidung der Tatsache, dass im Rahmen der Inlandsgermanistik der Erwerb der Muttersprache und entsprechende kulturelle Kontexte bereits vorausgesetzt werden können, in der Auslandsgermanistik dagegen muss die Fremdsprache auch während des Studiums weiter gepflegt werden, was sich auf Gegenstände und Interessen im Bereich der Lehre und der Forschung niederschlägt. Dies ist jedoch in vielen Fällen eine große Herausforderung für die Lehrkörper der Auslandsgermanistik, da über die Vermittlung der Lehrinhalte hinaus, die Kluft zwischen akademischem Gegenstand und Fremdsprache geschlossen werden muss. Die Herausforderung aber gilt ebenso der Innovation, da nicht selten Methoden und Ansätze aus den Auslandsgermanistiken impulsgebend für die germanistische Hochschullandschaft gewesen sind. Im Rahmen der Hochschullehre hat sich der in der Inlandsgermanistik nicht existierende Gegenstandsbereich der ‚Landeskunde’ in eine ‚interkulturell orientierte Landeskunde’ oder, gänzlich vom Spracherwerb abgegrenzt, in eine kulturwissenschaftliche Lehre umgewandelt. Somit wird einer statischen Faktenvermittlung in Bezug auf ‚deutsche Kultur’ entgegengesteuert und das kommunizierende Subjekt in den Mittelpunkt gestellt, wobei die Kompetenz zur “negotiation of meaning across cultures” ein wichtiges Ziel der Lehre ausmacht. Gerade im Rahmen einer ‚interkulturell orientierten Landeskunde’ sollen die Studierenden eigenkulturelle Verhaltensweisen relativieren, fremdkulturelle Denkansätze erkennen und die Fähigkeit zwischen der eigenen und der fremden Kultur kommunikativ zu vermitteln, entwickeln.
Die deutsche Sprache im albanischen Hochschulbereich und ihre Zukunftsperspektiven
Authors: KADZADEJ BRIKENA 
Published: March 2018

In diesem Beitrag wird der Versuch unternommen, sich mit der Entwicklung der deutschen Sprache im albanischen Hochschulbereich, ihren Problemen, Tendenzen und Perspektiven auseinanderzusetzen. Zunächst soll ein allgemeiner geschichtlicher Überblick zur Situation der deutschen Sprache vor der Wende (bis 1990) bis zur Gegenwart gegeben werden. Obwohl das kleine Land Albanien 50 Jahre lang ein weißer Fleck in Europa war, hat der Sprachenerwerb hier eine relativ lange Tradition. Schon in den 20er und 30er Jahren fängt das Interesse an dem deutschsprachigen Raum undan dem Deutschen an. In den 70er und 80er Jahren unterlag die gesamte Fremdsprachenausbildung der „staatlichen und politischen Planung“.Zu Beginn der 90er Jahre öffnete sich Albanien dem Westen. Mit der Notwendigkeit zu kooperieren und sich in die europäische Nachbarschaft zu integrieren, erhielten die Fremdsprachen einen neuen Stellenwert. Das Interesse der Albaner stieg besonders für die Sprachen, die bisher nicht gelernt werden konnten, insbesondere für das Italienische (wegen der geographischen Nähe) und für das Deutsche.Im Jahre 1992 wurde Deutsch als Studienfach an der Fremdsprachenfakultät (vormals Fakultät für Philologie und Geschichte) in Tirana eingeführt. Erst nach der Wende wurde die erste Germanistikabteilung in Tirana eröffnet und nach deren Vorbild wurden Deutschabteilungen auch in Elbasan, Shkodra und Korca etabliert. Im akademischen Schuljahr 2004/2005 wurde der Bologna-Prozess zunächst an den albanischen Universitäten umgesetzt, was für neue Entwicklungen des Deutschen im albanischen Hochschulbereich sorgte.Im Jahre 2016 wurde das Gesetz für die neue Hochschulreform von dem albanischen Parlament verabschiedet, das nicht nur mit neuen Einstellungen im Bildungswesen und Änderungen in der Organisationsstruktur der Hochschulen verbunden ist, sondern auch zu großen Diskussionen im Hochschulbereich führte.Es wird in diesem Beitrag auf das Profil des Lehrkörpers, die Zulassungsvoraussetzungen für das Hochschulstudium und Studiengangprofile und Abschlüsse eingegangen. Abschließend werden die Probleme und die Perspektiven der deutschen Sprache im albanischen Hochschulbereich in all deren Zusammenhängen dargestellt.
Mortality, fertility, and economic development: An analysis of 201 countries from 1960 to 2015
Authors: Li Qingfeng , Tsui Amy O. , Liu Li , Ahmed Saifuddin 
Published: March 2018

Background: The efficient utilization of the economic opportunities effected by rapid reductions in fertility and mortality is known as the demographic dividend. In this paper, our objectives are to (1) estimate the contribution of fertility and mortality decline during the period 1960-2015 to demographic dividend due to change in age structure, and (2) assess the economic consequences of population age structure change. Methods: Employing the cohort component method, we performed population projections with different scenarios of changes in mortality and fertility between 1960 and 2015 in 201 countries. We specifically focused on low- and middle-income countries in Asia, Latin America and the Caribbean (LAC), Northern Africa, and sub-Sahara Africa (SSA) Results: The child dependency ratio, defined as the number of children (0-14 years) per 100 working age population (15-64 years), would be 54 higher than the observed level in 2015 in both Asia and LAC, had fertility not declined. That means that every 100 working age population would need to support an additional 54 children. Due to the less substantial fertility decline, child dependency ratio would only be 16 higher if there were no fertility decline in SSA. Global GDP (constant 2011 international $) would be $19,016 billion less than the actual level in 2015 had the fertility decline during 1960-2015 not occurred, while the respective regional decreases are $12,390 billion in Asia, $1,985 billion in LAC, $484 billion in Northern Africa, and $321 billion in SSA. Conclusions: SSA countries may accelerate the catch-up process in reducing fertility by investing more in family planning programs. This will lead to a more favorable dependency ratio and consequently facilitate a demographic dividend opportunity in SSA, which, if properly utilized, will spur economic development for the coming decades.
Classification and characterisation of brain network changes in chronic back pain: A multicenter study
Authors: Mano Hiroaki , Kotecha Gopal , Leibnitz Kenji , Matsubara Takashi , Nakae Aya , Shenker Nicholas , Shibata Masahiko , Voon Valerie , Yoshida Wako , Lee Michael , Yanagida Toshio , Kawato Mitsuo , Rosa Maria Joao , Seymour Ben 
Published: March 2018

Background. Chronic pain is a common, often disabling condition thought to involve a combination of peripheral and central neurobiological factors. However, the extent and nature of changes in the brain is poorly understood. Methods. We investigated brain network architecture using resting-state fMRI data in chronic back pain patients in the UK and Japan (41 patients, 56 controls), as well as open data from USA. We applied machine learning and deep learning (conditional variational autoencoder architecture) methods to explore classification of patients/controls based on network connectivity. We then studied the network topology of the data, and developed a multislice modularity method to look for consensus evidence of modular reorganisation in chronic back pain. Results. Machine learning and deep learning allowed reliable classification of patients in a third, independent open data set with an accuracy of 63%, with 68% in cross validation of all data. We identified robust evidence of network hub disruption in chronic pain, most consistently with respect to clustering coefficient and betweenness centrality. We found a consensus pattern of modular reorganisation involving extensive, bilateral regions of sensorimotor cortex, and characterised primarily by negative reorganisation - a tendency for sensorimotor cortex nodes to be less inclined to form pairwise modular links with other brain nodes. In contrast, intraparietal sulcus displayed a propensity towards positive modular reorganisation, suggesting that it might have a role in forming modules associated with the chronic pain state. Conclusion. The results provide evidence of consistent and characteristic brain network changes in chronic pain, characterised primarily by extensive reorganisation of the network architecture of the sensorimotor cortex.
Economic Estimation of the Available Biomass following Logging Operations in Western Oregon and Washington
Authors: Zamora-Cristales Rene , Boston Kevin , Long Justin , Sessions John 
Published: March 2018

Abstract
A two-step method was developed to estimate the economically available biomass from forest operations in the Pacific Northwest. Step 1 measures the amount of biomass in piles from a variety of logging operations. Step 2 applies logistics models to determine the amount of biomass that is recoverable by computing the extraction costs depending on the distance from the landing. Cable units included only the biomass piles located at the landings, while ground-based units computed the collection and transport of each pile to the most cost-effective landing using geographic information system and simulation tools. This approach was applied to operations on state and private timberlands in Oregon and Washington. For the cable logging units, the average pile size was 46.7 green tonnes of residue, and this material was either on or next to the roadside landing. It produced few large piles with an average of 24.75 green tonnes per ha. For ground-based operations, approximately 54 percent of the residue in the harvest units was 90 m or less from the landing. Collection cost increases as the material is farther from the landing and ranged between about $17.6 per green tonne at distances of 15.2 m to $37 per green tonne at distances of 213 m from the landing. Depending on the distance from the landing to the bioenergy facility, it is possible to estimate how far from the landing into the forest to reach to economically collect the biomass.
Violence against women in women’s perception; an examination of women’s shelters in Turkey<p>Kadın algısında kadına yönelik şiddet; Türkiye’de kadın sığınma evleri üzerine bir inceleme
Authors: Ayan Sezer 
Published: March 2018

Aim. To determine if there is a correlation between women’s traditional views about marriage and the family (TBAMAK), patriarchal beliefs about marriage (PBAM), and beliefs about wife beating (IBWB) and type and frequency of violence they are subjected to. Method. This study’s universe comprises of 64 women housed in Turkish Ministry of Family and Social Policies’ women protection houses because of domestic violence. Findings. Data gathered during this study demonstrates that there is a direct correlation between having traditional beliefs about marriage and women being subjected to sexual violence. There is a direct correlation between having beliefs justifying wife beating (JUWB) and women being subjected to sexual violence. There is also an inverse correlation between having patriarchal beliefs about marriage and women being subjected to physical, economical, psychological violence and neglect. Furthermore, a statistically significant correlation was demonstrated between having traditional beliefs about family and marriage and frequency of being subjected to violence. Results. Data suggests that having traditional and patriarchal beliefs about family and marriage and having beliefs justifying wife beating are partially determinative about the type and frequency of violence women are subjected to. Extended English summary is in the end of Full Text PDF (TURKISH) file. ÖzetAmaç, Kadınların aile ve evlilik hakkında geleneksel (TBAMAF) ve ataerkil inançları (PBAM) ve kadın dövmeye ilişkin inançları (IBWB) ile uğradıkları şiddetin türü ve sıklığı arasında bir ilişki olup olmadığını belirlemektir. Yöntem. Çalışmanın evrenini, Türkiye’de Aile ve Sosyal Politikalar Bakanlığına bağlı kadın konuk evlerinde aile içinde şiddete maruz kalmaları nedeni ile koruma altına alınan 64 kadın oluşturmaktadır. Bulgular. Aile ve evlilik hakkında geleneksel inançlara ve kadın dövmeyi haklılaştırmaya ilişkin (JUWB) inaçlara sahip olma ile cinsel şiddete maruz kalma arasında doğrudan; evlilik hakkında ataerkil inançlara sahip olma ile cinsel şiddet hariç, fiziksel, ekonomik, psikolojik şiddete ve ihmale maruz kalma arasında ters yölü bir ilişki vardır. Öte yandan kadınların şiddete uğrama sıklığı ile sadece aile ve evlilik hakkında geleneksel inançları arasında anlamlı bir ilişki olduğu tespit edilmiştir. Sonuç. Veriler, kadınların aile ve evlilik hakkında geleneksel ve ataerkil inançlara ve kadın dövmeye ilişkin inançlara sahip olmalarının maruz kaldıkları şiddetin türü ve sıklığı üzerinde kısmen belirleyici olduğunu göstermektedir.
Application of atomic absorption spectrometry with continuous light source to analyze selected metals important for human health in different parts of oranges
Authors: Szwerc Wojciech , Sowa Ireneusz 
Published: March 2018

ABSTRACT
The publication describes the application of high-resolution continuum source atomic absorption spectrometry (H-R CS AAS) to determine some physiologically essential and toxic elements occurring in citrus fruits of different origins. Before analysis, the samples were mineralized using a mixture of deionized water and 69% nitric acid 3:1 (v/v) in high pressure microwave digestion at 188°C during one hour.
The obtained validation parameters for AAS such as high linearity (the correlation coefficient R > 0.997) and high precision expressed as relative standard deviation (%RSD) were satisfactory for quantification.
Cadmium at concentration range from 0.29 to 0.43 mg/kg was determined in all tested samples, however the obtained values did not exceed Polish standards. The higher concentration of potassium comparing to sodium and calcium was noted in each investigated samples. The highest variation was observed for calcium, its concentration strongly depended on the country of origin.
Application of low-level laser radiation with TiO2, Ag/TiO2 and S/TiO2 on Streptococcus salivarius isolated from the oral cavity
Authors: Panas Marta , Baryliyak Adriana , Korniychuk Olena 
Published: March 2018

ABSTRACT
In our research, we determine the effect of low-level laser irradiation with nanoparticles on Streptococcus salivarius. Photodynamic killing of periodontopathogenic bacteria may be an alternative to the systemic application of antibacterial drugs used in the treatment of periodontal diseases. The application of photosensitizing nanoparticles and their excitation by visible light of blue spectra enables effective killing of periodontopathogens. This data combined with the results demonstrates that TiO2, AgTiO2 and S/TiO2 can inhibit the proliferation of Streptococcus salivarius due to its high photocatalytic activity, which irreversibly damages the cell walls and membranes.
Physical properties and caffeine release from creams prepared with different oils
Authors: Wojciechowska Katarzyna , Zun Maria , Dwornicka Dorota , Swiader Katarzyna , Kasperek Regina , Poleszak Ewa 
Published: March 2018

Abstract
Caffeine is a methylxanthine typically found in the Coffee Arabica L plant. Generally, caffeine is well-known as a orally administered mild stimulant of the central nervous system. However, for cosmetic purpose, caffeine is an active compound ingredient, at 7% concentration, in several anticellulite products. The efficiency of this mode of delivery is not fully understood. Hence, the aim of the study was to ascertain the effectiveness of particular carriers to release this ingredient. In so doing, we prepared six creams based upon different oils (Sesame oil, Rice oil, Walnut oil, Coconut oil, Sweet almond oil and Jojoba oil), containing 5% of caffeine, and compared the release of the substance from the obtained preparations. Initially, all of the creams were subjected to a variety of physical tests, among these being for slippage and spreadability. Furthermore, their rheological properties were evaluated. Subsequently, the creams were tested for caffeine release. In the slippage and spreadability tests, the coconut oil-based cream was revealed as having the best parameters. However, the rheological tests showed that all of the preparations had the pseudoplastic character of flowing according to the Ostwald de Waele power law model. The power low index (n) for all the preparations was from 0.2467-0.3179 at 20°C and 0.2821-0.3754 at 32°C. At 20°C, the Sesame oil-, Walnut oil-, Sweet almond oil- and Jojoba oil-based creams were thixotropic, but at 32°C, thixotropy appeared only in the Walnut oil-based creams.
The release studies, conducted by way of an extracting chamber (according to Polish Pharmacoeia IX) in the Paddle Apparatus (according to Polish Pharamcopoeia IX), showed that the amount of released caffeine is the largest in the case of Jojoba oil-based cream, at 85.23% ± 0.8% (SD), and the least in the case of Coconut oil-based cream, at 62,78%± 0.87% (SD).
The alteration in peripheral neutrophils of patients with chronic kidney disease
Authors: Yevgenyevna Muravlyova Larissa , Molotov-Luchankiy Vilen Borisovich , Yemelyevna Bakirova Ryszhan , Akylbekovna Turmukhambetova Anar , Anatolyevich Klyuyev Dmitriy , Andreevna Demidchik Ludmila , Alexandrovna Kolesnikova Yevgeniya 
Published: March 2018

Abstract
Recent findings have demonstrated the impaired functions of neutrophils of patients with chronic renal failure. The purpose of our research was to study oxidative modified proteins, as well as the histone spectrum in neutrophils drawn from patients with chronic kidney disease, and to estimate the ability of neutrophils to form spontaneous neutrophil extracellular traps. In this work, we have assumed that metabolic alteration in neutrophils may develop at early stages of chronic kidney disease. Materials and methods: Neutrophils obtained from patients with various stages of chronic kidney disease and degrees of chronic renal failure were used. As control, blood samples obtained from 32 healthy individuals was employed. In the examined neutrophils, advanced oxidation protein products, protein reactive carbonyl derivatives, as well as nucleosomal histones were detected. The ability of neutrophils to form spontaneous neutrophil extracellular traps was estimated. Our results have demonstrated an increase of nucleosomal histones in neutrophils of all patients with chronic kidney disease. Moreover, our work fixes the rate of growth of intracellular advanced oxidation protein products and the decreasing of protein reactive carbonyl derivatives in neutrophils from patients with chronic kidney disease. Furthermore, we demonstrate the presence of the neutrophils with altered oxidative status and the decomposition of the histone spectrum in the circulation of patients with chronic kidney disease.