bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vesicle Trafficking, Autophagy and Nanoparticles: A Brief Review
Authors: Li Tianzhong , Yang Mengsu 
Published: September 2019

Background:Nanomedicine shows a huge promise for incurable diseases. So far, more than 50 nanoparticles have been approved by FDA and around 80 nanoformulations are currently in clinical trials. Nanoparticles possess several advantages over traditional drugs, including higher biocompatibility and bioavailability. One of the challenges for their wide application is insufficient understanding of the molecular network related to internalization of particles and intracellular release of cargos.Objective:This article aims to review the interactions between nanoparticles, vesicle transportation and autophagy pathways. The underlying molecular machinery is also discussed.Methods:For each step of the vesicle trafficking and autophagy, details of signaling pathways are described for a better understanding of the interactions between delivery vehicles and biomolecules within the cell.Conclusion:The selection of cellular uptake route mainly depends on physical characteristics of nanoparticles. For nanoparticles modified with ligands, they undergo receptormediated endocytic pathway. Once residing within the cells, cargos are released after disruption of endosomes, a mechanism called ‘proton sponge effect’. Besides, internalized nanoparticles either can be exocytosized, or they initiate the autophagy response, affecting the intracellular distribution of drugs.
Web-Based Module for the Collection of Electronic Patient-Reported Outcomes in People Living With HIV in Nouvelle Aquitaine, France: Usability Evaluation
Authors: Barger Diana , Leleux Olivier , Conte Valérie , Sapparrart Vincent , Gapillout Marie , Crespel Isabelle , Erramouspe Marie , Delveaux Sandrine , Wittkop Linda , Dabis François , Bonnet Fabrice 
Published: September 2019

BackgroundPatient-reported outcomes (PROs) can be of great value for both research and chronic disease management. We developed a new module of the ANRS CO3 Aquitaine cohort study’s Web-based data capture and visualization solution (APPEGE 2.0) for the collection of electronic PROs among people living with HIV cared for in Nouvelle Aquitaine, France.ObjectiveThis study aimed to evaluate the usability of 2 successively developed prototypes of ARPEGE 2.0’s electronic PROs module before launching a pilot study, owing to the novelty of the proposed data collection method for our setting and specific characteristics of the target population.MethodsA total of 2 sequential rounds of empirical, task-based usability evaluations were conducted, involving 8 research staff and then 7 people living with HIV. Evaluators provided written feedback during round 1 and oral feedback during round 2. Evaluators who completed the full set of tasks responded to the System Usability Scale (SUS). We assessed changes in SUS scores between rounds and concluded usability testing when SUS scores reached a ceiling effect, defining good usability a priori as a usability score of 70.ResultsInsights were generated regarding the visibility of system status and the match between the system and the real world that improved the module’s usability. Research staff evaluators reported mean SUS scores of 65 (SD 18.87) and patient evaluators reported mean SUS scores of 85 (SD 5.4; P=.032).ConclusionsSoftware modifications, informed by successive rounds of usability testing, resulted in sufficient gains in usability to undertake piloting. Insights generated during evaluations prompted us to find the appropriate balance between optimal security and ease of use.Trial RegistrationClinicalTrials.gov NCT03296202; https://clinicaltrials.gov/ct2/show/NCT03296202International Registered Report Identifier (IRRID)RR2-10.2196/10.2196/resprot.9439
Remote Patient Monitoring in Adults Receiving Transfusion or Infusion for Hematological Disorders Using the VitalPatch and accelerateIQ Monitoring System: Quantitative Feasibility Study
Authors: Tonino Rik Paulus Bernardus , Larimer Karen , Eissen Okke , Schipperus Martin Roelof 
Published: September 2019

Background
Frequent vital sign monitoring during and after transfusion of blood products and certain chemotherapies or immunotherapies is critical for detecting infusion reactions and treatment management in patients. Currently, patients return home with instructions to contact the clinic if they feel unwell. Continuous monitoring of vital signs for hematological patients treated with immunotherapy or chemotherapy or receiving blood transfusions using wearable electronic biosensors during and post treatment may improve the safety of these treatments and make remote data collection in an outpatient care setting possible.

Objective
This study aimed to evaluate patient experiences with the VitalPatch wearable sensor (VitalConnect) and to evaluate the usability of data generated by the physIQ accelerateIQ monitoring system for the investigator and nurse.

Methods
A total of 12 patients with hematological disorders receiving red blood cell transfusions, an intravenous (IV) proteasome inhibitor, or an IV immunotherapy agent were included in the study and wore the VitalPatch for 12 days. Patients completed questionnaires focusing on wearability and nurses completed questionnaires focusing on the usability of the VitalPatch.

Results
A total of 12 patients were enrolled over 9 months, with 4 receiving red blood cell transfusions, 4 receiving IV proteasome inhibitors, and 4 receiving IV immunotherapy. These patients were treated for diseases such as multiple myeloma, myelodysplastic syndrome, and non-Hodgkin lymphoma. Of these patients, 83% (10/12) were aged 60 years and older. A total of 4 patients (4/12, 33%) withdrew from the study (3 because of skin irritation and 1 because of patch connection issues). Patients wore biosensor patches at baseline and for 1-week post administration. Patient-reported outcomes (PROs) were collected at baseline, day 1, day 5, and day 8. No difference in the PRO was observed when nurses or patients applied the patch. PRO data indicated minimal impact on the patient’s life. Ease of use, influence on sleep, impact on follow-up of health, or discomfort with continuous monitoring did not change between baseline and day 8. Changes in PRO were observed on day 5, where a 20% (2/10) increase in skin irritation was reported. Withdrawals because of skin irritation were reported in all cases when wearing the second patch. Nurses reported the placement of the VitalPatch to be easy and felt measurements to be reliable.

Conclusions
Generally, the VitalPatch was well tolerated and shown to be an attractive device because of its wearability and low impact on daily activities in patients, therefore making it suitable for implementation in future studies.
Efficiency of Arabica Coffee Processing Unit in Ngada Regency
Authors: Djawa Kornelia Ngina , Irham Irham , Waluyati Lestari Rahayu 
Published: September 2019

Village-based processing unit is a small-scale agricultural processing industry based in rural areas. It is a breakthrough program in accelerating the growth of farmers' income and increased employment. The product processing unit has a goal of obtaining maximum benefit. In order to achieve maximum profit and continuous processing of coffee, the processing unit should pay attention to the efficiency aspect. The purpose of this research is to know the efficiency of the coffee processing unit in Ngada regency and the improvement strategy for processing unit of an inefficient result to be efficient. The analysis method used is Data Envelopment Analysis (DEA) of Charnes, Cooper, and Rhodes (CCR) model and Banker, Charnes, and Cooper (BCC) model with output orientation. The research sample is the management of the coffee processing unit, with the total of 40 respondents. The result of this research shows that the efficiency measurement using DEA method of the CCR model produces coffee processing unit in Ngada regency which efficiently reaches 9 units or 22.5% while 31 or 77.5% other processing units are inefficient. On the BCC model unit, the efficient coffee processing is 20 units or 50%, while the other 20 units or 50% are in the inefficient state. The inefficient processing unit is because the available input is not used optimally. Inefficient processing units can be achieved efficiently by referring to efficient processing units within their peer groups by adjusting the excessive amount of input usage
Analysis of Object and Attractiveness of Community-Based Ecotourism in Coastal Area of Mempawah Regency
Authors: Dolorosa Eva , Kurniati Dewi 
Published: September 2019

Mangrove ecotourism in the Mempawah coastal area began to be developed and initiated by local communities who are concerned in the sustainability of the mangrove ecosystem. This is also supported by the increasing number of tourists to visit ecotourism, so that the development of ecotourism needs to be supported by tourist attractiveness as well as learning to tourists to care about their environment in accordance with the principles of ecotourism namely responsible travel to natural areas, conserving the environment and improving the well-being of local people. This paper focuses on analyzing the potential value of community-based ecotourism objects and its attractiveness. The assessment indicator based on the guidelines for assessment of natural tourism attractiveness was used to assess the objects and attractiveness in three specific ecotourism locations which are managed by local communities in Mempawah, namely Pasir, Bakau, and Mendalok Village. This study involves the participation of tourists who have visited the ecotourism site. The study found that the potential value of the object and attractiveness mangrove ecotourism in Mempawah Area was 3,105 with an average score of 388 meaning that it ispotentially developed, and also increasing recommendations related to community-based ecotourism development.
Etika Global dalam Dunia yang Sedang Berubah: Mengelola Kebangkitan Asia dan Kemunduran Barat
Authors: Rosyidin Mohamad 
Published: September 2019

Kebangkitan Cina, yang menurut David Shambaugh, adalah sebab utama kebangkitan Asia (Asia Rising), kerap dipersepsi secara negatif oleh sebagian pakar geopolitik Barat. John Mearsheimer berpendapat bahwa “Jika Cina terus mengalami pertumbuhan ekonomi yang luar biasa selama beberapa dekade mendatang, maka Amerika Serikat dan Cina akan saling bersaing dalam hal keamanan yang dapat memicu perang”. Senada dengan itu, David Shambaugh juga berpendapat bahwa “Beijing cenderung menunjukkan perilaku yang keras dan kasar kepada banyak negara tetangganya di Asia, selain kepada Amerika Serikat dan Uni Eropa. Pesimisme semacam itu sangat mendominasi cara pandang Barat terhadap Cina. Akibatnya, sikap Barat kepada Cina cenderung dilandasi oleh logika ancaman ketimbang peluang kerjasama.
China’s International Strategy and How to Pursue It
Authors: Aftah Chairul 
Published: September 2019

China is a major actor in the Asia Pacific region and global because of its economy, politic, military, social and cultural capabilities. In world history, this position has been built through several stages. In the Post-World War II, China was considered dangerous despite its inability to show diplomatic influence in international relations, especially with the United States and its allies. It was only after 1980, after Deng Xiaoping came to power, China began to increase their influence through a variety of domestic and international policies. As a result, China’s existence has been increasingly recognized in various fields. Domestically, China considers that the increase of its multisectoral capability as an effort to put China on an equal footing with other actors that have better capabilities. In contrast, for the other states, the increase of China’s ability has been perceived as a threat because it raised China’s bargaining power. Thus, it is crucial for China to convince others that its progress is not a threat. In improving its capabilities, China formulated an international strategy in both regional and international level. Therefore, China sought to implement these strategies by improving its relationship with other actors.
Isolation, identification, and detection of ACC deaminase gene-encoding rhizobacteria from rhizosphere of stressed pineapple
Authors: Jaya Dori Kusuma , Giyanto Giyanto , Nurhidayat Novik , Antonius Sarjiya 
Published: September 2019

ACC deaminase is a microbial cytoplasmic enzyme that cleaves ACC, a precursor of ethylene, in the stressed plant. The aims of this study were to isolate, identify, and detect the presence of ACC deaminase gene-encoding rhizobacteria from the rhizospheric soil of pineapple plants that have been exposed to abiotic and biotic stress, specifically herbicide, flooding, and Phytophthora spp. stress. A total of 49 rhizobacterial isolates were obtained, seven of which were observed for their growth on DF medium containing 3 mM L-1 ACC. The four best-growing isolates were selected for genomic DNA extraction. They were molecularly identified as Stenotrophomonas maltophilia (3), Burkholderia territorii (2A), Pseudomonas oryzihabitans (5B), and Bacillus tropicus (1E). A set of primers, 105F-acdS 5’-TGCCAAGCGTGAAGACTGC-3’ and 244R-acdS 5’-GGGTCTGGTTCGACTGGAT-3’, were constructed to amplify the ACC deaminase gene (acdS). Based on melt peak curve analysis, four products appeared to show a specific single peak at 86, 89, 87, and 89.5°C, indicating a single product was produced. In addition, a Blast search showed that these four products met the ACC deaminase feature and their acdS sequences were clustered into an ancestral group compared with the bacterial strains deposited in GenBank. These results suggest that ACC deaminase gene-encoding rhizobacteria from a pineapple plantation of tropical origin may affect the acdS sequences and may contribute to the host plant’s stress tolerance.
DETERMINANTS OF CUSTOMER`S SWITCHING INTENTION BASED ON EXPERIENCE AND SHARIA VALUE CONGRUITY
Authors: . Muthmainah , Cholil Muhammad 
Published: September 2019

This study aims to examine the factors that influence the customer`s switching intention, which are influenced by customer satisfaction and customer loyalty based on customer experience and congruity of sharia values. The sample size of 195 Sharia banks customers in Surakarta was taken using convenient sampling method. The research analysis used hierarchical regression with customer satisfaction as the independent variable, customer`s switching intention as the dependent variable and customer loyalty as a mediator variable. Besides that, it also uses customer experience and congrueity to sharia values as a moderator variable.Validity test, reliability test and classic assumption test have been carried out and the results meet the criteria according to the specified standards. The results of the research analysis show that customer satisfaction has a positive and significant effect on customer loyalty and has a negative effect on the customer`s switching intention and customer loyalty has a negative effect on customer`s switching intention. Customer loyalty partially mediates the effect of customer satisfaction on customer`s switching intention. However, the customer experience and congrueity sharia value does not strengthen or weaken the influence of customer satisfaction on customer loyalty and on customer`s switching intention and does not strengthen or weaken the influence of customer loyalty on customer`s switching intention. The theoretical and practical implications of the results of research that are considered relevant and need to be discussed can be used as orientation and direction for future research
EFEK FAKTOR DEMOGRAFI DAN KARAKTERISTIK BISNIS ONLINE TERHADAP MINAT PENGAJUAN KREDIT MIKRO
Authors: Karambut Fermico , . Hartoyo , Nurmalina Rita , Najib Mukhamad 
Published: September 2019

This study aimed to see whether intention of applying for microcredit was influenced by factors of demographic and online business characteristics. The selection of respondents used convenience sampling method by collecting qualitative and descriptive information through online survey to 235 online seller who were members of the Indonesian Online Business Association (APOI). The results of the study using logistic regression analysis proved that only the type of online business that was significantly related to the intention of applying for micro credit. Financial institutions should offer credit products that are suitable for the type of online business to increase intention. Further research based on the type of business and online products will provide better overview of online MSME intnetion models.
ORGANIZATIONAL CITIZENSHIP BEHAVIOR DALAM PERSPEKTIF ISLAM (APLIKASI TAKWA)
Authors: Elmi Farida 
Published: September 2019

The aim of this research is to describe and understand Organizational Citizenship Behavior (OCB) in Islamic perspective (application of piety) of ITL Trisakti employees in Jakarta. This is a study case research with a qualitative approach. The data were collected through observation and interview. The informants of this study are employees of ITL Trisakti. This thesis is the effort to study scientifically the meaning of OCB in Islamic perspective, and how is piety implemented. Good comprehension of the subjects over piety and its internalization has shaped and formed OCB. Regarding OCB of ITL Trisakti employees, it can be inferred that of all dimension of altruism; civic virtue, advocating high moral standards, and removal of harm, merely all are observable within the employees. Piety can be a discourse in educational institution research and contributes to achieve organizational goals
Ángulos de perfil facial frente a parámetros estándar en análisis fotométrico en estudiantes de 17-18 años del Colegio Amazonas. Estudio comparativo
Authors: Tóala-Tapia Adrián Isaac , Balseca-Ibarra Eliana Guadalupe 
Published: September 2019

<p style="text-align: justify;"><strong>Objetivo:</strong> Determinar si existe o no variación del perfil facial en los estudiantes del colegio Nacional Amazonas enfrentados a parámetros estándar mediante análisis fotométrico. <strong>Materiales y métodos: </strong>El tipo de estudio es descriptivo, observacional ya que se trabajó con fotografías en los que participaron un total de 80 alumnos que aceptaron de manera voluntaria el estudio. Los estudiantes fueron sometidos a una fotografía de perfil de la cara a 60cm de un fondo celeste del cual cuelga una plomada. Se obtuvieron 80 fotografías por medio de la cámara Nikon D300 ubicada a 1.50m del objetivo. Las fotografías fueron encuadradas e ingresadas al programa Viewbox 4 en dónde se marcaron puntos en el perfil blando para la determinación de ángulos y así formar una base de datos para comparar. Los datos obtenidos se realizaron con la utilización de los programas Microsoft Excel y el programa estadístico SPSS el cual analizo a base del test estadístico T-Student.</p>
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La evaluación de la satisfacción en salud: un reto en la atención estomatológica
Authors: Berenguer-Gouarnaluse Maritza Del Carmen , Medianeja-Álvarez Nuria Rosa , Montoya-Medina Marlene 
Published: September 2019

<p style="text-align: justify;">Con el desarrollo de la humanidad, y en particular con los avances en el terreno de la medicina, es necesario hacer un llamado para humanizar la asistencia en salud y ofrecer servicios de mayor calidad. La calidad en la atención médica debe estar basada en actividades encaminadas a garantizar los servicios de salud accesibles y equitativos con profesionales óptimos y teniendo en cuenta los recursos disponibles, logrando la satisfacción del usuario con la atención recibida. El presente trabajo es un estudio descriptivo y transversal, con el objetivo de evaluar el resultado mediante la determinación de niveles de satisfacción de los proveedores de salud bucal, con la atención que brindan y de los usuarios con el servicio recibido nivel de satisfacción de los estomatólogos generales y licenciados en atención estomatológica a la población preescolar y escolar del reparto Abel Santamaría , y usuarios en el período comprendido de enero – diciembre del 2015, mediante la metodología propuesta en el documento para este fin. El universo estuvo constituido por el total de Especialistas de Estomatología General Integral que se encontraban laborando (N=2), Licenciadas en Atención Estomatológica (N=3), que realizan la actividad preventiva, y usuarios una muestra de 148 escolares y 47 pre-escolares, para la evaluación de la satisfacción profesional. Se evaluó la satisfacción como dimensión de la calidad mediante criterios, indicadores y estándares utilizados, el cual fue adecuado. </p>
La auditoría en el proceso de control
Authors: Castillo-Cabeza Segundo Nelson 
Published: September 2019

<p style="text-align: justify;">En este artículo se presenta un conjunto de elementos teóricos de la Auditoría, partiendo de su evolución histórica, caracterizando cada una de las fases que ha transitado, definición de la misma y su papel en el proceso de control. Se concluye que la auditoría juega un papel fundamental en el mantenimiento de las empresas o servicios que se necesitan, por cuanto implica el control de los recursos de los cuales ella dispone, a su vez la calidad de las Auditorías es uno de los temas más importantes a perfeccionar en esta rama, pues de esto depende la confiabilidad de los estados de control de las empresas.</p>
Factores de riesgos asociados al estado nutricional de personal administrativo
Authors: Granda-Barba Yazmin de las Mercedes , Chávez-Gallegos Amalin M. , Aspiazu-Miranda Elvia P. 
Published: September 2019

<p style="text-align: justify;">Un estudio realizado por la Organización Panamericana de salud (OPS) a través de Iniciativa de Diabetes para la Américas (DIA) y la Federación Internacional de la Diabetes (FID), estimaron que habrían 18 millones de latinoamericanos afectados hasta 2010 llegará a 40 millones para el 2025 con un 69% en adultos en países en vías de desarrollo y 100% para los países desarrollados. Las enfermedades metabólicas son causas de morbilidad y mortalidad en el mundo <strong> El objetivo</strong>: de este estudio es determinar los factores de riesgo en el estado nutricional del personal administrativo de la Universidad Estatal de Milagro<strong>. Metodología</strong>: Es una investigación de carácter observacional no experimental, descriptivo mediante encuestas y medidas antropométricas. <strong>Resultados</strong>: Se evalúo 100 trabajadores administrativos de 25 a 60 años, se observó mayor asociación de factores de riesgo en el grupo etario 25 a 45 años que representa el 67% de los encuestados con afectación del estado nutricional. <strong>Conclusiones: </strong>El sobrepeso, la obesidad, el sedentarismo y los malos hábitos alimenticios repercutan negativamente en el estado nutricional, generando a largo plazo el desarrollo de enfermedades metabólicas: diabetes, enfermedades cardiovasculares, hipertensión; con una mayor incidencia de obesidad en el grupo etario del sexo femenino de 25 a 45 años. </p>