bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of a Combination of Vertical and Horizontal Boreholes in Massive Blasting of Benches in the Surface Quarry Rodež
Authors: Tori Matija , Vajović Stanojle , Goleš Niko , Muhić Elvir , Peternel Miha 
Published: February 2018

Abstract
This article deals with the extraction of minerals (limestone/marl/flysch) in the quarry Rodež, which is located in western Slovenia. During the extraction of minerals in a quarry, drilling and blasting of benches are used. The focus of the article is on the analysis of the parameters related to drilling and blasting in surface excavations when using a combination of explosions and introducing horizontal wells along with vertical holes in the bench. On the basis of the analysis of basic parameters through a combination of drilling horizontal wells and charging those with the ammonal + Anfex explosive, analyses of effects of seismic disturbances on potentially affected buildings have also been conducted. The article is connected to and deals exclusively with the basic parameters of drilling and blasting, with the introduction of horizontal drilling and with the analysis of seismic measurements of threatened buildings in accordance with the German standard German Institute for Standardisation (DIN) 4150 during the use of a new method of blasting.
Mycophenolate for persistent complex regional pain syndrome, a parallel, open, randomised, proof of concept trial
Authors: Goebel Andreas , Jacob Anu , Frank Bernhard , Sacco Paul , Alexander Guillermo , Philips Ceri , Bassett Paul , Moots Robert 
Published: February 2018

Abstract

Background and aims:
Current therapies for persistent complex regional pain syndrome (CRPS) are grossly inadequate. With accruing evidence to support an underlying immunological process and anecdotal evidence suggesting potential efficacy of mycophenolate, we wished to explore the feasibility and effectiveness of this treatment in patients with CRPS.

Methods:
A randomised, open, parallel, proof of concept trial was conducted. Patients with Budapest research criteria CRPS of >2-year duration and moderate or high pain intensity (numeric rating scale score ≥5) were enrolled. Eligible patients were randomised 1:1 to openly receive mycophenolate as add-on treatment, or their usual treatment alone, over 5.5 months. They then switched to the other treatment arm for 5.5 months. The main outcome was average the patients’ average pain intensity recorded over 14 days, between 5.0 and 5.5 months post randomisation, on 11-point (0–10) numeric rating scales, compared between trial arms. Skin sensitivities and additional outcomes were also assessed.

Results:
Twelve patients were enrolled. Nine provided outcomes and were analysed for the main outcome. Mycophenolate treatment was significantly more effective than control [drug-group mean (SD): pre: 7.4 (1.2)- post: 5.2 (1.3), n=4, control: pre: 7.7 (1.4)- post: 8.1 (0.9), n=5; −2.8 (95% CI: −4.7, −1.0), p=0.01, analysis of covariance]. There were four treatment responders (to mycophenolate treatment either before, or after switch), whose initial exquisite skin hyper-sensitivities, function and quality of life strongly improved. Side effects including itchiness, skin-cryptitis, increased pain, and increased depression caused 45% of the subjects to stop taking mycophenolate.

Conclusions:
Mycophenolate appears to reduce pain intensity and improve quality of life in a subgroup of patients with persistent CRPS.

Implications:
These results support the feasibility of conducting a definite trial to confirm the efficacy and effect size of mycophenolate treatment for persistent CRPS (EudraCT 2015-000263-14).
Sequences Flanking the Gephyrin-Binding Site of GlyRβ Tune Receptor Stabilization at Synapses
Authors: Grünewald Nora , Jan Audric , Salvatico Charlotte , Kress Vanessa , Renner Marianne , Triller Antoine , Specht Christian G. , Schwarz Guenter 
Published: February 2018

AbstractThe efficacy of synaptic transmission is determined by the number of neurotransmitter receptors at synapses. Their recruitment depends upon the availability of postsynaptic scaffolding molecules that interact with specific binding sequences of the receptor. At inhibitory synapses, gephyrin is the major scaffold protein that mediates the accumulation of heteromeric glycine receptors (GlyRs) via the cytoplasmic loop in the β-subunit (β-loop). This binding involves high- and low-affinity interactions, but the molecular mechanism of this bimodal binding and its implication in GlyR stabilization at synapses remain unknown. We have approached this question using a combination of quantitative biochemical tools and high-density single molecule tracking in cultured rat spinal cord neurons. The high-affinity binding site could be identified and was shown to rely on the formation of a 310-helix C-terminal to the β-loop core gephyrin-binding motif. This site plays a structural role in shaping the core motif and represents the major contributor to the synaptic confinement of GlyRs by gephyrin. The N-terminal flanking sequence promotes lower affinity interactions by occupying newly identified binding sites on gephyrin. Despite its low affinity, this binding site plays a modulatory role in tuning the mobility of the receptor. Together, the GlyR β-loop sequences flanking the core-binding site differentially regulate the affinity of the receptor for gephyrin and its trapping at synapses. Our experimental approach thus bridges the gap between thermodynamic aspects of receptor-scaffold interactions and functional receptor stabilization at synapses in living cells.
Can Serial Dependencies in Choices and Neural Activity Explain Choice Probabilities?
Authors: Lueckmann Jan-Matthis , Macke Jakob H. , Nienborg Hendrikje 
Published: February 2018

During perceptual decisions the activity of sensory neurons covaries with choice, a covariation often quantified as “choice-probability”. Moreover, choices are influenced by a subject's previous choice (serial dependence) and neuronal activity often shows temporal correlations on long (seconds) timescales. Here, we test whether these findings are linked. Using generalized linear models, we analyze simultaneous measurements of behavior and V2 neural activity in macaques performing a visual discrimination task. Both, decisions and spiking activity show substantial temporal correlations and cross-correlations but seem to reflect two mostly separate processes. Indeed, removing history effects using semipartial correlation analysis leaves choice probabilities largely unchanged. The serial dependencies in choices and neural activity therefore cannot explain the observed choice probability. Rather, serial dependencies in choices and spiking activity reflect two predominantly separate but parallel processes, which are coupled on each trial by covariations between choices and activity. These findings provide important constraints for computational models of perceptual decision-making that include feedback signals.SIGNIFICANCE STATEMENTCorrelations, unexplained by the sensory input, between the activity of sensory neurons and an animal's perceptual choice (“choice probabilities”) have received attention from both a systems and computational neuroscience perspective. Conversely, whereas temporal correlations for both spiking activity (“non-stationarities”) and for a subject's choices in perceptual tasks (“serial dependencies”) have long been established, they have typically been ignored when measuring choice probabilities. Some accounts of choice probabilities incorporating feedback predict that these observations are linked. Here, we explore the extent to which this is the case. We find that, contrasting with these predictions, choice probabilities are largely independent of serial dependencies, which adds new constraints to accounts of choice probabilities that include feedback.
C-class functions on fixed and common fixed point results for cyclic mappings of Omega-distance
Authors: Ansari Arslan Hojat Hojat , Shatanawi Wasfi 
Published: February 2018

In this paper, we derive and formulate many fixed point results of cyclic form under contractive conditions based on implicit relations in the setting of Ω-distance. Our results improve and generalize many existing results in the literature. Also, we introduce an example to show the validity of our main result.
Randomly stopped sums with exponential-type distributions
Authors: Danilenko Svetlana , Markevičiūtė Jurgita , Šiaulys Jonas 
Published: February 2018

Assume that {ξ1, ξ2, …} are independent and possibly nonidentically distributed random variables. Suppose that η is a nonnegative, nondegenerate at zero and integer-valued random variable, which is independent of {ξ1, ξ2, …}. In this paper, we consider conditions for η and {ξ1, ξ2, …} under which the distribution of the random sum {ξ1 + ξ2 + … + ξη} belongs to the class of exponential distributions.
The influence of different compounds of trace elements on the biomass and synthesis of exopolysaccharides of mycelium Trametes versicolor (Polyporaceae, Polyporales)
Authors: Al-Maali G. A. 
Published: February 2018

This article presents the results of research on the influence of citrates of zinc, manganese and copper, obtained by the method of aquanotechnology, on a number of physiological indicators of a valuable medicinal mushroom Trametes versicolor 353. Previously we detected that these metal citrates stimulated the growth of mycelium more intensively than sulfates of the above-mentioned metals in equal concentrations. In the present research we investigated the influence of these metal citrates on the parameters of assimilation of carbon and nitrogen sources, metal ion accumulation and synthesis of exopolysaccharides. The degree of metals ions accumulation in the mycelium was studied by the method of optical emission spectroscopy with an inductively coupled plasma. The economic coefficient of biomass synthesis and impact of nitrogen assimilation were higher on media with the metals citrate than on the medium with the sulfates of the studied metals. Thus, the highest economic coefficient of biomass synthesis (36%) was observed on the medium with copper citrate. Also, copper citrate (amongst the studied metals) increased the level of assimilation of the nitrogen source by up to 35%, versus 18% on the control medium. Quantitative analysis of trace elements in biomass showed that the mycelium accumulated an equal amount of zinc or manganese ions on both types of media (with citrate or sulfate of these metals). However, on the medium with copper citrate, mycelium of T. versicolor 353 accumulated copper ions better then on a medium with copper sulfate: 82.9 μg/g of biomass on the medium with copper sulfate versus 162.0 μg/g of biomass on the medium with copper citrate. Also the results show that a significant increase of biomass (by 79% relative to the control) on the copper citrate medium is due to a threefold reduction of the exopolysaccharides amount. This data indicates a greater biological activity of copper citrate, relative to copper sulfate. Only zinc citrate raised both the synthesis of biomass and the synthesis of exopolysaccharides by 37% and 29% respectively ( relative to the control trial).
Lower vertebrates of Sehlabathebe National Park, Lesotho
Authors: Kopij G. 
Published: February 2018

Five snake, four lizard, nine amphibian (all anurans) and three fish species were recorded in the Apline grasslands of the Sehlabathebe National Park, South-Eastern Lesotho, Southern Africa. They include rare, threatened and endemic species, some of which are restricted to the Drakensberg / Maloti region. The following species were recorded: snakes Lamprophis aurora, L. fuscus, Hemachatus haemachatus, Bitis arietans, B. atropos; lizards Trachylepsis punctatissima, Tropidosaura montana, Pseudocordylus melanotus, Afroedura nivaria; amphibians (anurans) Xenopus laevis laevis, Bufo gariepensis nubicolus, Cacosternum striatum, Amietia dracomontana, A. angloensis, A. fuscigula, A. umbraculata, Strongylopus fasciatus, Semnodactylus wealii; fishes Labeobarbus aeneus, Pseudobarbus quathlambae and Oncorhynchus mykiss. Species with high conservation priorities include: Lamprophis fuscus, Tropidosaura cottrelli, Pseudocordylus spinosus, Amietia umbraculata, A. drakomontana, Strongylopus fasciatus and Pseudobarbus quathlambae.
Effect of hydrogen peroxide on Na+,K+-ATPase activity in spermatozoa of infertile men
Authors: Fafula R. V. , Meskalo О. I. , Lychkovskyy E. I. , Iefremova U. P. , Onofrovych O. K. , Maksymyuk H. V. , Melnyk O. V. , Nakonechnyi I. A. , Vorobets D. Z. , Vorobets Z. D. 
Published: February 2018

Na+,K+-ATPase plays an essential role in sperm motility, hyperactivation, chemotaxis, acrosome reaction etc. Na+,K+-ATPase is sensitive to ROS insult. Apart from production of highly reactive molecules, H2O2 can exert a number of direct effects on cells, their metabolism and enzymes. In the present study, exposure to exogenous H2O2 was used to characterize the effects of H2O2 on Na+,K+-ATPase activity in spermatozoa of infertile men with different forms of pathospermia. It was shown that Na+,K+-ATPase activities in spermatozoa of infertile men with different forms of pathospermia were inhibited by exposure to H2O2 (50−500 μM). H2O2, one of the most toxic oxygen species, has the ability to depress Na+,K+-ATPase activity in a dose-dependent manner. Severe inhibition of the hydrolytic activity was observed when higher H2O2 were used. The time course of incubation with 100 μM H2O2 showed a sharp decrease in the enzyme activity during the first 5 min of incubation for both normozoospermic and pathozoospermic men. The enzymatic activity of Na+,K+-ATPase in the sperm was completely destroyed at 20 min for asthenozoospermic men and 30 min for normozoospermic men. We show that an administation of H2O2 inhibited Na+,K+-ATPase activity in normozoospermic samples with IC50 of 106.6 ± 7.9 μM. IC50 for patients with asthenozoospermia was two times less than for healthy men with preserved fertility. For other studied groups, the differences in IC50 were not significant. These observations suggest that Na+,K+-ATPase in pathozoospermic samples is more vulnerable to H2O2-induced damage than in normozoospermic men. The Hill coefficient was significantly increased only for patients with asthenozoospermia, indicating increased positively cooperative binding. The decreases in Na+,K+-ATPase hydrolase activity in H2O2-treated sperm cells in men with normozoospermia were largely attenuated by exogenous GSH at 5 mM. This suggests that GSH partially protects the Na+,K+-ATPase from inhibition under experimental oxidative stress. However, treatment of oligo-, astheno- and oligoasthenozoospermic samples with 100 μM H2O2 and 5 mM GSH did not result in protection of Na+,K+-ATPase against induced oxidation, suggesting that the impaired Na+,K+-ATPase in pathozoospermic samples appears to be an irreversible event. In contrast, presence of GSH only after H2O2 treatment does not reverse Na+,K+-ATPase inhibition. This study has provided a deeper insight into the role Na+,K+-ATPase plays in sperm cells,it also could offer clues to the clinical application of antioxidant therapy in male infertility therapy.
Hindfoot Endoscopy: Correlation of the Preoperative Indications with the Perioperative Endoscopic Findings
Authors: UNAL A. Meric 
Published: February 2018

Background: The aim
of this study was to review the disorders treated with hindfoot endoscopy and
investigate the detected ratio and type of combined pathologies. The second aim
was to evaluate the preoperative and peroperative findings before and at the
time of hindfoot endoscopy.Patients and Methods: 81
hindfoot endoscopies of the 77 patients performed between 2010-2015 were
reviewed. Demographic informations, preoperative physical and radiological
findings and operative data of all patients were noted. Preoperative physical
examination for hindfoot was performed in a standart fashion for all patients. Weight-bearing
anteroposterior and lateral radiographs were taken for all patients. Magnetic
resonance imaging(MRI) was performed to all patients except obvious prescence
of bony impingement. The hindfoot endoscopy was performed to all patients at
prone position under either spinal or general anesthesia with standart
posteromedial and posterolateral portals described as Van Dijk et al.Results: In this
case series; the most detected preoperative indications were flexor hallucis
longus tendinopathy(27.1%), symptomatic os trigonum(22.2%) as a cause of
posterior ankle impingement and insertional achilles tendinopathy(20.9%). The most
detected endoscopic findings were flexor hallucis longus
tendinopathy(33.3%), symptomatic os
trigonum(19.3%), and retrocalcaneal bursitis(16.2%).16 patients(19.7%) had
preoperatively detected combined pathologies. In 32 patients(39.5%), a new
indication was added to preoperative indication.

Conclusion: Posterior
ankle impingement and peri-achilles pathologies are the most seen indications
for this technique. It is important that we all must aware of perioperatively
detected new indications and rare conditions.
ESENSI WAHYU DAN ILMU PENGETAHUAN
Authors: Baiti Rosita , Harith Muhammad 
Published: February 2018

This study discusses the related of revelation with science. Reviewing revelation does not mean ignoring the study in the perspective of science, because in the revelation itself is found so many verses that encourage human beings to conduct thinking activities in reviewing everything especially the universe for the creation of a civilized life. Science has indeed contributed greatly to the welfare of live and life, but it is realized that the results of science especially concerning truths that have a high value can not be obtained. Therefore, the information of revelation becomes important and needed by humans in addition to cover the weaknesses of science, but also as a guide to life for the happiness of the world and the hereafter.
Günlük Kullanım Ürünlerinin Sol El Kullanıma Uygunluğu
Authors: Boratav Olcay , Gürdal Nur 
Published: February 2018

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Bu çalışmanın amacı, sol el kullanımı
dünya nüfusunun yaklaşık %10’ luk bir bölümünü oluştururken, sağ el kullanımına
oranla geri planda kalmasının nedenlerini ve günlük kullanım eşyalarının sol el
kullanımına uygunluğunu incelemektir. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Araştırmanın amaç ve önemi belirlendikten
sonra, primitif dönem ve dinlerde sağ ve sol kavramından başlanarak, bilimsel
olarak sağ ve sol el kullanımı, toplumsal çekinceler ve sol el kullanan
çocukların eğitimine yansımaları araştırılmıştır. Elde edilen göstergeler
doğrultusunda tasarım, ürün-kullanıcı ilişkileri, evrensel tasarım kavramları
ele alınmış günlük kullanım ürünlerinin sol el kullanımına uygunluğu ve
kullanıcıların yaşadıkları zorluklar karşısında geliştirilen özel üretim
ürünler değerlendirilerek kavramsal çerçeve oluşturulmuştur. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Sonuç olarak; primitif dönemden günümüze,
sol kavramı ve sol el kullanımı farklılık olarak algılanmaktadır. Yapılan
birçok bilimsel araştırma göstermektedir ki; gerek çevresel gerek kalıtımsal
nedenlerle şekillenen el tercihi, sağ el kullanımı kadar, sol el kullanımı da
normal bir durumdur. El kullanımının belirginleştiği dönemden itibaren aile de
başlayan, okulda devam eden eğitim sürecinde, çocukların farklı bir el
kullanımına sahip olduklarını anlamaları ve çoğu günlük kullanım ürünlerinde
yaşadıkları zorluklar dikkat çekmektedir. İlerleyen dönemlerde bu durum
farklılığı kabullenme ve ürünlerin sol el kullanımına uygun olup olmamasına
bağlı olarak ürünü tercih etmek ya da etmemek yönünde şekillenmektedir. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Bu noktada; bir ürünün fikir olarak
ortaya çıkışından itibaren kullanıcıyla kurduğu iletişim iyi ya da kötü yönde
gelişim göstermektedir. Sol el kullanımına uygun olmayan ürünlerin,
kullanıcıların karşılaştıkları sorunlar göz önüne alınarak yeniden şekillenmesi
söz konusudur. Günümüzde özel üretim adı altında sol el kullanımına uygun
ürünler piyasada bulunmaktadır. Ancak her an her yerde ulaşılabilirliği
yaygınlaşmış durumda değildir. Sadece bu ürünlerin bulunduğu mağazalar,
internet üzerinden satış yapan siteler ve markaların özel üretim ürünleri
olarak kullanıcıya erişim amaçlanmaktadır. Fakat tanıtım ve reklamın yeterli
düzeyde olmaması kullanıcıya erişim açısından bir engel teşkil etmektedir. &nbsp;

&nbsp; &nbsp; &nbsp;&nbsp;Yapılan araştırma ve incelemeler sonucu,
bu tarz erişimin kullanıcı arz- talep ilişkilerini yeterli düzeyde
karşılayamadığı ortaya çıkmıştır.
Development and Validation of the Marijuana Motives Measure Short Form
Authors: Mezquita Laura , Ruiz-Valero Lucía , Martínez-Gómez Naiara , Ibáñez Manuel I. , Ortet Generós 
Published: February 2018

Marijuana motives are a proximal variable to marijuana use. This research aimed to adapt and validate the short form of the Marijuana Motives Measure (MMM; Simons, Correia, Carey, y Borsari, 1998), the MMM SF, in Spanish. The sample comprised 232 participants (mean age = 25.11 (7.58), 50.43% males) who had tried marijuana at least once in their lifetime. Item and Rasch analyses were performed to choose the final pool of 15 items. Confirmatory Factor Analysis (CFA) showed an adequate 5-factor structure (S-BX2(80) = 121.30, p = .002; NNFI = .944; CFI = .958; IFI = .959; MFI = .915; RMSEA = .047(0.029, 0.063); AIC = -38.70), and the multi-group CFA between males and females showed acceptable fit indices (S-BX2(160) = 230.01, p = .000; NNFI = .900; CFI = .924; IFI = .927; MFI = .860; RMSEA = .062(.043, .078); AIC = -89.99). The questionnaire indicated metric (S-BX2diff (15) = 13.61, p = .556)), scalar (S-BX2diff (15) = 23.15, p = .081)) and error measurement invariance (S-BX2diff (15) = 8.65, p = .895)) between gender groups. The internal consistencies and ordinal omega of the scales were between .79 and .90. In the regression analysis, enhancement, coping and low conformity motives predicted frequency and quantity of marijuana smoked. The best predictor of frequency and quantity consumed during the heaviest smoking period was enhancement, while coping and, to a lesser extent, low conformity, were the only predictors of cannabis-related problems when marijuana frequency and quantity were controlled for. The MMM SF shows adequate psychometric properties and is a suitable instrument to assess marijuana motives, especially during time-limited sessions.