bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deutlicher Anstieg neu diagnostizierter Hepatitis B- und Hepatitis C-Fälle nach Einführung des Screenings in die allgemeine Gesundheitsuntersuchung (ehemals „Check-up 35“) in Deutschland
Authors: Hüppe Dietrich , Serfert Yvonne , Cornberg Markus , Wedemeyer Heiner 
Published: November 2024

ZusammenfassungDie Weltgesundheitsorganisation (WHO) hat 2016 beschlossen, bis 2030 90% der weltweiten Hepatitis B und C-Virus-infektionen zu identifizieren, 80% zu behandeln und die Mortalität um 65% zu senken. Die Bundesregierung hat sich 2016 diesen Zielen angeschlossen. Daher wurde ab dem 01.10.21 ein einmaliges Screening auf Hepatitis B und C in die Gesundheitsuntersuchung (GU) ab 35 Jahren für GKV-Versicherte aufgenommen. Die vorliegende Arbeit bewertet die bisherigen Teilnahmeraten an der GU, die Effektivität des Programms anhand der Meldedaten des Robert Koch-Institutes (RKI) und schätzt die Entwicklung der Behandlungszahlen ab.Mitteilungen des Zentralinstitutes der Kassenärztlichen Versorgung (ZI) und des Wissenschaftlichen Institutes der Ortskrankenkassen (WIdO) sowie Abrechnungsdaten der Kassenärztlichen Vereinigung (KBV) wurden bzgl. der GU zusammengestellt und die Meldedaten des RKI unter Verwendung von SURVSTAT@RKI 2.0 analysiert.Zwischen 2007 und 2021 nahmen etwa 83% aller Versicherten mindestens einmal an einer GU teil. Ab dem 4. Quartal 2021 stieg die Anzahl der neu diagnostizierten Fälle von Hepatitis B und C an. Im Jahr 2022 betrug die Zunahme für Hepatitis B 92% und für Hepatitis C 68%. Dieser Trend setzte sich im Jahr 2023 fort, wobei die Neudiagnosen von Hepatitis B um 160% (auf 22.795 Fälle) und von Hepatitis C 121% (auf 10.508 Fälle) im Vergleich zu 2021 zunahmen. Die Analyse der Abrechnungsdaten der KBV zeigte, dass die Zunahme der Neudiagnosen eine starke Korrelation zwischen der Anzahl der Neudiagnosen im Rahmen der GU und der Gesamtzahl der Diagnosen insgesamt aufweist.Die Entscheidung des Gemeinsamen Bundesausschusses (G-BA), das Hepatitis B und C Screening in die GU aufzunehmen, scheint zielführend, um die bisher unentdeckten Fälle der Erkrankungen zu erkennen. Die Ziele der WHO erscheinen erreichbar.
Severe gastroparesis complicated by gastric perforation caused by lightchain amyloidosis
Authors: Rietz Michael , Weber Tobias , Schaller Tina , Luitjens Jan Hendrik , Uhrmacher Luise , Messmann Helmut , Probst Andreas 
Published: November 2024

AbstractAL-Amyloidosis is a rare systemic disease that can occur in patients with monoclonal gammopathy or multiple myeloma. As multiple organs may be affected by deposition of amyloid fibrils, the clinical presentation varies considerably, and the diagnostic process may be challenging.We report on a 59-year-old female who suffered from gastroesophageal reflux symptoms, nausea, epigastric pain, and meteorism over several years. Repeated upper GI endoscopies including biopsies and CT scans were unremarkable except for unspecific enlargement of mesenterial lymph nodes.A few weeks after a surgical hiatal hernia repair with fundoplication, the patient developed massive distension of the stomach and the proximal duodenum resulting in gastric perforation. Histopathological staining of gastric biopsies and mesenterial lymph nodes using hematoxylin and eosin was unremarkable. Because of endoscopic findings (submucosal hematomas, and ulcerations) and the unexplained severe motility disorder, histopathological staining was performed using Congo red. Extensive amyloid deposits were seen. Further workup confirmed AL amyloidosis caused by monoclonal gammopathy. Specific oncological treatment was started.The rare differential diagnosis of amyloidosis should be taken into account in patients with unexplained motility disorders, unspecific gastrointestinal symptoms, and abdominal lymphadenopathy. In the presented case, delayed diagnosis of AL amyloidosis in the gastrointestinal tract led to severe gastroparesis resulting in gastric perforation. Specific histopathologic staining can confirm the diagnosis.
Trends in Gabapentin Use in Neonatal Intensive Care Units from 2005 to 2020
Authors: Roberts Annette G. , Kilpatrick Ryan , Diaz Lindsey D. , Benjamin Scott , Espinoza Santiago Athziry J , Jallow Bubacarr , Monteith Madison F. , Rumsey Sarah , Clark Reese H. , Zimmerman Kanecia , Benjamin Daniel K. , Greenberg Rachel G. 
Published: November 2024

Objective This study aimed to analyze trends in gabapentin use in neonatal intensive care units (NICUs) and examine demographic characteristics, diagnoses, and concomitant medications associated with its use.
Study Design Cohort study of 987,181 infants hospitalized in the NICU from 2005 to 2020.
Results Eighty-five infants (<0.01%) received gabapentin. From 2009 to 2020, there was a 1,055% relative increase in gabapentin use (p < 0.01). The median birth weight was 2,160 g (25th, 75th percentiles: 875, 3,080 g) in gabapentin-exposed infants compared with 2,498 g (1,890, 3,210 g) in unexposed infants (p < 0.001). Over half (55%) of infants receiving gabapentin were born prematurely, 54% (n = 45) had chronic lung disease, 46% (n = 39) had gastrostomy tubes, and 34% (n = 29) had drug withdrawal syndrome; 49% (n = 42) and 27% (n = 23) received opioids and benzodiazepines, respectively.
Conclusion Use of gabapentin was rare but increased over time despite limited research on its safety and efficacy in infants, illuminating the need for further studies.
Key Points
A Survey of Minimally Invasive Surfactant Use in the United States
Authors: Ahn Natasha , Derrick Matthew , Hussain Walid 
Published: November 2024

Objective Minimally invasive surfactant therapy (MIST) has become the standard of care in delivering surfactant noninvasively in many parts of the world, particularly throughout Europe; however, centers in the United States have been slower to adopt it. The most recent assessment of the use of MIST in the United States was in 2018 by Kurepa et al. Considering the increasing evidence favoring MIST, this paper reassessed the current rate of utilization and aims to examine barriers to MIST implementation.
Study Design A web-based survey was distributed to approximately 4,500 individuals in the American Academy of Pediatrics Section of Neonatal-Perinatal Medicine (AAP SoNPM) mailing list. The questions were aimed at addressing MIST usage in the United States, examining barriers for neonatology providers to implement MIST into their practice, and determining the use of sedation during the MIST procedure.
Results Of the 381 respondents, 39% used MIST as part of their practice, which was an increase from 15% in 2018. The most prevalent barrier to implementation was the lack of procedural training. There was a large increase in the use of sedation for the procedure compared with 2018.
Conclusion MIST use among AAP SoNPM respondents has more than doubled since 2018; InSurE (INtubation-SURfactant delivery Extubation) remains the most prevalent method of surfactant delivery in non-intubated patients. The list of different types of barriers and comments provided by respondents can be a resource for units planning to implement MIST.
Key Points
Deep Inferior Epigastric Perforator Flap with Implant Placement has a Favorable Complication Profile Compared with Implant-Only or Flap-Only Reconstruction
Authors: Wang Carol , Roy Nikita , Montalmant Keisha E. , Shamamian Peter , Seyidova Nargiz , Oleru Olachi , Graziano Francis , Jacobs Jordan M.S. , Sbitany Hani , Henderson Peter W. 
Published: November 2024

Abstract
Background Hybrid deep inferior epigastric perforator (DIEP) flap and simultaneous silicone implant breast reconstruction procedures (“DIEP + I”) have many conceptual advantages compared with either reconstruction method alone, but the outcomes of DIEP + I reconstruction have not yet been well studied. Therefore, the purpose of this study was to compare the outcomes of DIEP + I with implant-only and DIEP-only reconstruction.
Methods A retrospective review was conducted of patients undergoing DIEP + I, implant-only, and DIEP-only breast reconstruction from 2019 to 2023 at a single institution. Demographics and complication rates were compared between groups.
Results A total of 145 patients were included in the DIEP + I (N = 26), implant-only (N = 59), and DIEP-only (N = 60) groups. The DIEP + I group had a lower overall complication rate than implant-only reconstruction (18.4 vs. 41.1%, p = 0.014), which was primarily due to the lower incidence of infections in the DIEP + I group (2.6 vs. 22.2%, p = 0.006). Accordingly, DIEP + I reconstruction decreased the odds of infection by 90% (OR = 0.095, p = 0.024) compared with implant-only reconstruction. The DIEP + I group had similar rates of wound healing and implant-related complications compared with the implant-only and DIEP-only groups, and no patients in the DIEP + I group experienced flap loss.
Conclusion DIEP + I breast reconstruction had a lower rate of infectious complications than implant-only reconstruction, and no higher rate of flap compromise or wound healing complications. This technique could be considered as a means of minimizing infection risk in patients with other risk factors who are seeking implant-based reconstruction, and of enhancing breast projection in patients who are seeking DIEP flap reconstruction.
Individual and County-Level Factors Associated with Severe Maternal Morbidity at Delivery: An Investigation of a Privately Insured Population in the United States, 2008 to 2018
Authors: Matas Jennifer L. , Mitchell Laura E. , Salemi Jason L. , Bauer Cici X. , Ganduglia Cazaban Cecilia 
Published: November 2024

Objective Few studies have explored the impact of county-level variables on severe maternal morbidity (SMM) subtypes. To address this gap, this study used a large commercial database to examine the associations between individual- and county-level factors and SMM.
Study Design This retrospective cohort study used data from the Optum's deidentified Clinformatics Data Mart Database from 2008 to 2018. The primary outcomes of this study were any SMM, nontransfusion SMM, and nine specific SMM subtypes. Temporal trends in the prevalence of SMM and SMM subtypes were assessed using Joinpoint Regression. Multilevel logistic regression models were used to investigate the association of individual- and county-level factors with SMM.
Results Between 2008 and 2018, there was not a significant change in the prevalence of any SMM (annual percent change [APC]: −0.9, 95% confidence interval [CI]: −2.2, 0.5). Significant increases in prevalence were identified for three SMM subtypes: other obstetric (OB) SMM (APC: 10.3, 95% CI: 0.1, 21.5) from 2013 to 2018, renal SMM (APC: 8.5, 95% CI: 5.5, 11.6) from 2008 to 2018, and sepsis (APC: 23.0, 95% CI: 6.5, 42.1) from 2014 to 2018. Multilevel logistic regression models revealed variability in individual and county risk factors across different SMM subtypes. Adolescent mothers (odds ratio [OR]: 2.10, 95% CI: 1.29, 3.40) and women in the 40 to 55 (OR: 1.67, 95% CI: 1.12, 2.51) age group were found to be at significant risk of other OB SMM and renal SMM, respectively. For every increase in rank within a county's socioeconomic social vulnerability index (SVI), the risk of respiratory SMM increased 2.8-fold, whereas an increase in rank in the racial/ethnic minority SVI was associated with a 1.6-fold elevated risk of blood transfusion.
Conclusion This study underscores the complex association between individual and county factors associated with SMM, emphasizing the need for multifaced approaches to improve maternal care.
Key Points
The Plasma Proteome and Risk of Future Venous Thromboembolism—Results from the HUNT Study
Authors: Brækkan Sigrid K. , Onsaker Asbjørn L. , Nøst Therese H. , Tang Weihong , Hindberg Kristian D. , Morelli Vania M. , Guan Weihua , Jonasson Christian , Folsom Aaron R. , Hveem Kristian , Hansen John-Bjarne 
Published: November 2024

Background This study aimed to identify novel plasma proteins associated with first-lifetime venous thromboembolism (VTE) and molecular pathways involved in VTE pathogenesis.
Methods A case–cohort comprising incident VTE cases (n = 294) and a randomly sampled age- and sex-weighted subcohort (n = 1,066) was derived from the Trøndelag Health Study (HUNT3, n = 50,800). Blood samples were collected and stored at cohort inclusion (2006–2008), and participants were followed up to 5 years. Proteome-wide analyses was performed using the 7k SomaScan® proteomics platform, and weighted Cox-regression models adjusted for age, sex, and sample batch were conducted, with the Bonferroni method applied to account for multiple testing. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were applied on the top-ranked 200 proteins associated with VTE.
Results Out of 7,288 human proteins, 7 proteins were significantly associated with higher VTE risk with p-value <6.9 × 10−6 (hazard ratios per 1 standard deviation increase in protein levels ranging from 1.39 to 1.86). Except for coagulation factor VIII and tumor necrosis factor soluble receptor II, these proteins were novel associations and included collagen alpha-3(VI):BPTI/Kunitz inhibitor, histo-blood group ABO system transferase, peroxidasin, human epididymis protein 4, and regulator of G protein signaling 3. KEGG analyses of the top-ranked 200 proteins revealed significant pathway enrichment of nine proteins in the complement (mainly lectin pathway) and coagulation (mainly intrinsic pathway) cascades.
Conclusion Our proteome-wide analysis led to discovery of five novel protein candidates associated with 5-year risk of future VTE. KEGG analyses supported an interplay between the complement and coagulation pathways in the pathogenesis of VTE.
One-Pot Three-Component Access to Furan and Thiophene Derivatives
Authors: Chen Zhihua , Wang Teng , Yu Xinhong , Bao Ruipeng , Wang Yao , Lin Xinbo , Tan Jinglin 
Published: November 2024

AbstractThe furan and thiophene skeleton structures are widely present in natural products and synthetic drugs, and display multiple bioactivities. An effective one-pot three-component reaction to access furan and thiophene derivatives from 2-bromo-5-(dichloromethyl)furan or -thiophene; cyanoacetate esters, cyanoacetamides, or malononitrile; and aliphatic secondary amines has been developed. The multicomponent reaction for the construction of new C–N and C–C bonds in one pot is simple, mild, and efficient, and the yield of the target product is as high as 96%.
Splenic Artery Embolization for Post-Liver Transplant Ascites
Authors: D'Amico Giuseppe , Del Prete Luca , Diago Teresa , Partovi Sasan , Gadani Sameer , Quintini Cristiano 
Published: November 2024

AbstractOrthotopic liver transplantation (OLT) is the treatment of choice for end-stage liver disease. However, OLT may be associated with certain postoperative management challenges. Though refractory ascites (RA) is not a common complication post-OLT, it can have a significant impact on patient outcomes and quality of life. RA post-OLT can be caused by portal hyperperfusion. In this article, a systematic review of the literature was pursued to analyze the effectiveness of splenic artery embolization (SAE) with RA after OLT. Data sources included MEDLINE, EMBASE, and CENTRAL from inception to March 2024. Studies reporting on patients treated with SAE for the management of RA following OLT, from inception to March 2024, were included. Morbidity, mortality, and clinical resolution were synthesized through a narrative review. A total of eight articles were identified, including 80 patients. In the majority of the patients, the SAE was performed using a vascular plug. After SAE, no cases associated with mortality were reported. Severe complications (Clavien III) occurred in 2.5% (n = 2) of patients. The success rate, with clinical resolution of symptomatology (ascites), ranged in these articles between 97 and 100%. The approach to the management of RA post-OLT should focus on identifying the underlying cause. If the RA is associated with portal hyperperfusion, it can be managed with SAE. Particularly proximal SAE seems to be highly effective for the resolution of ascites and the procedure is associated with a low complication rate.
Biliary Complications after Liver Transplant: Timeline, Spectrum, Management Algorithm, and Prevention
Authors: Roy Akash , Goenka Mahesh Kumar 
Published: November 2024

AbstractBiliary complications are the most common complications seen after liver transplantation (LT) with an incidence ranging between 10 and 15% and increasing in the setting of increased access to living donor liver transplant and utilization of marginal grafts. Among the biliary complications, the most common are anastomotic strictures, nonanastomotic strictures, and biliary leaks, which have a variable time of presentation posttransplant. The risk factors for the development of biliary complications include surgical techniques, type of grafts, prolonged ischemia, primary disease etiology, and associated post-LT complications. The approach to a diagnosis in an appropriate clinical setting involves a stepwise approach involving clinical history, assessment of risk factors, biochemical abnormalities, and appropriate imaging. Therapeutic options revolve around endoscopic retrograde cholangiopancreatography and percutaneous transhepatic biliary drainage, with surgical intervention being reserved in case of failure of these modalities. Preventive strategies with machine perfusion techniques are promising, while use of T-tubes for prevention of complications remains controversial.
Revisiting the apparent horizon finding problem with multigrid methods
Authors: Hui Hon-Ka , Lin Lap-Ming 
Published: November 2024

Abstract
Apparent horizon plays an important role in numerical relativity as it provides a tool to characterize the existence and properties of black holes on three-dimensional spatial slices in 3+1 numerical spacetimes. Apparent horizon finders based on different techniques have been developed. In this paper, we revisit the apparent horizon finding problem in numerical relativity using multigrid-based algorithms. We formulate the nonlinear elliptic apparent horizon equation as a linear Poisson-type equation with a nonlinear source, and solve it using a multigrid algorithm with Gauss–Seidel line relaxation. A fourth order compact finite difference scheme in spherical coordinates is derived and employed to reduce the complexity of the line relaxation operator to a tri-diagonal matrix inversion. The multigrid-based apparent horizon finder developed in this work is capable of locating apparent horizons in generic spatial hypersurfaces without any symmetries. The finder is tested with both analytic data, such as Brill–Lindquist multiple black hole data, and numerical data, including off-centered Kerr–Schild data and dynamical inspiraling binary black hole data. The obtained results are compared with those generated by the current fastest finder AHFinderDirect (Thornburg 2003 Class. Quantum Grav.
21 743), which is the default finder in the open source code Einstein Toolkit. Our finder performs comparatively in terms of accuracy, and starts to outperform AHFinderDirect at high angular resolutions (

∼

1
∘

) in terms of speed. Our finder is also more flexible to initial guess, as opposed to the Newton’s method used in AHFinderDirect. This suggests that the multigrid algorithm provides an alternative option for studying apparent horizons, especially when high resolutions are needed.
Time-harmonic optical flow with applications in elastography
Authors: Melnyk Oleh , Quellmalz Michael , Steidl Gabriele , Jaitner Noah , Jordan Jakob , Sack Ingolf 
Published: November 2024

Abstract
In this paper, we propose mathematical models for reconstructing the optical flow in time-harmonic elastography. In this image acquisition technique, the object undergoes a special time-harmonic oscillation with known frequency so that only the spatially varying amplitude of the velocity field has to be determined. This allows for a simpler multi-frame optical flow analysis using Fourier analytic tools in time. We propose three variational optical flow models and show how their minimization can be tackled via Fourier transform in time. Numerical examples with synthetic as well as real-world data demonstrate the benefits of our approach.
DyPanVO: a robust monocular visual odometry in dynamic environments by utilizing multiple deep neural networks
Authors: Chen Shuo , Kong Dongdong , Lu Lixin , Chen Dongxing , Chen Dongdong 
Published: November 2024

Abstract
Traditional monocular visual odometry (VO) is typically based on the assumption of a static environment. However, it performs poorly in dynamic scenes, suffering from error accumulation and scale drift. To address these issues, a novel framework, named DyPanVO, was proposed, which incorporates multiple deep neural networks for feature point extraction, panoptic segmentation, and depth estimation. Firstly, learning-based methods are employed, specifically SuperPoint for robust feature extraction and LightGlue for accurate feature matching. Then, outlier points are eliminated by combining dynamic prior results from panoptic segmentation with epipolar geometry constraints to determine the motion state of objects. Additionally, the introduction of depth information ensures that scale is recovered and fundamentally solves the issue of error accumulation. Two types of experiment (outdoor and indoor scenes) are carried out to show the effectiveness of DyPanVO. Moreover, the comparison results demonstrate that it performs comparably with multi-view geometry-based and outperforms learning-based methods.
Physics with a glass of water
Authors: Pardo-Igúzquiza Eulogio , Dowd Peter A 
Published: November 2024

Abstract
The work presented here compiles and describes ten experiments using only a glass of water to illustrate fundamental physical concepts. Some of these experiments are classic textbook examples while others may be less known. However, we expect that all of them will be appreciated equally by physics teachers and students. The experiments are designed for high school students and teachers, offering an easy-to-implement, hands-on experience for teaching important physical concepts. We have not included experiments that require fire or dangerous substances, so that students can learn from these experiments in the classroom and can repeat them at home to reinforce the learning process and encourage interest in science in general and physics in particular.
Impact of enthusiasm psychology and assimilation avoidance on behavioral propagation in double-layer heterogeneous network
Authors: Jun Zhang , Liu Huiheng , Li Shenhong , Zhang Ningbo , Zhu XuZhen 
Published: November 2024

Abstract
To undercover the distinct impact of heterogeneous strategies on information diffusion, this paper develops a double-layer network to stimulate the information propagation process of individual with the enthusiasm psychology and the assimilation avoidance effect. The enthusiasm psychology is captured by an increasing adoption function and the assimilation avoidance effect is modeled by an oscillating adoption function. In the proposed double-layer network, an susceptible state(S-state) node accumulates information from its adopted state(A-state) neighbors and may evolve into the A-state according to the adoption probabilities in each layer. Then, the nodes keep the same state in the two layers anytime. Finally, the A-state may transition to the recovery state(R-state) if it receives the information and adopt it. The R-state node quits the information diffusion and does not transmit nor receive any information. This study analyzes the proportion of nodes in the R-state and their relative variance to characterize the information diffusion mechanism applying both theoretical and numerical methods. Results show that enhancing the individual’s enthusiasm psychology and the assimilation avoidance effect can accelerate the information propagation. When the two layers experience outbreaks that do not occur simultaneously, the propagation range exhibits a first-order discontinuous increase. When there are a dominate layer in the process of information spreading, the propagation range shows a second continuous boundary.