bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant chemotherapy followed by definitive local treatment in locally advanced sinonasal squamous cell carcinoma
Authors: Kim Jina , Hong Min Hee , Kim Hye Ryun , Lim Sun Min , Kim Chang Gon , Kim Da Hee , Sim Nam Suk , Hong Hyun Jun , Koh Yoon Woo , Kim Se-Heon , Wee Chan Woo , Lee Chang Geol , Keum Ki Chang , Kim Chang-Hoon , Kim Kyung Hwan 
Published: October 2024

BackgroundSinonasal squamous cell carcinoma (SCC) is a rare disease entity, comprising less than 5% of malignancies of the head and neck. While surgery is the primary treatment approach, neoadjuvant and adjuvant therapies play crucial roles in enhancing the prognosis of patients undergoing treatment with the goal of cure. In this study, we aimed to explore the treatment outcomes of neoadjuvant chemotherapy (NAC) in patients with locally advanced sinonasal SCC.MethodsMedical records of patients diagnosed of locally advanced (cT3-4b, N0-3) sinonasal SCC treated with a definitive aim between January 2005 and March 2023 were retrospectively reviewed. Patients were categorized into the following groups based on the initial treatment: NAC followed by surgery, NAC followed by concurrent chemoradiotherapy (CCRT), definitive CCRT, or upfront surgery. Initial treatment plan was decided by a multidisciplinary team. Primary endpoint was overall survival (OS) and objective response rate, and secondary endpoints were progression free survival (PFS), cumulative incidence of local and distant failures, and treatment-related toxicity. The treatment response was assessed according to the RECIST criteria.ResultsTotal 126 patients were included, and the median follow-up period was 25.6 months. The objective response rate to NAC was 48.2%. The subsequent resection rate was 70%, 42.9%, and 16.7% for patients with stage T3, T4a, and T4b disease, respectively. Two-year progression-free survival did not differ significantly between the NAC followed by surgery and upfront surgery groups (53.6% vs. 60.6%, P = 0.615) or between the NAC followed by CCRT and definitive CCRT groups (26.7% vs. 37.4%, P = 0.506).ConclusionNAC may be a valuable treatment option for patients with locally advanced sinonasal SCC, as it provides an opportunity for curative surgery and exhibits non-inferior oncological outcomes compared with upfront definitive local treatments.
Assessing Greece’s social vulnerability patterns in times of perma-crisis (2008–2022)
Authors: Melidis Michail , Tzagkarakis Stylianos Ioannis , Papadakis Nikos 
Published: October 2024

IntroductionThe study aims to map and analyse the development of social vulnerability patterns in Greece through a perma-crisis context (economic crisis, austerity, covid-19, energy, and inflation crisis) over the period 2008-2022.MethodsThe paper rests on the construction of a composite index of four key pillars of social vulnerability (employment, living conditions, health, and education) consisting of 15 selected variables obtained from the official Eurostat datasets and using PCA analysis.ResultsOur findings show that social vulnerability patterns in Greece demonstrate a considerable shift during the stated period where certain social groups (i.e., NEETs and precarious workers) seem to suffer the most. The first pattern (2008-2016) is largely characterized by the intensity and severity of the economic crisis and austerity measures, which contributed to the exacerbation of social vulnerability. The second pattern (2017-2022) presents a gradual decline mainly due to the recovery of the economy and a decrease in unemployment rates featuring a strong tendency to reach the pre-crisis levels in the years to come.DiscussionThe high levels of social vulnerability leading to social exclusion, poverty, and the widening of inequalities, impede the country’s resilience and recovery efforts and undermine social cohesion.
The efficacy of neuroendoscopic surgery treating patients with thalamic hemorrhage accompanied by intraventricular hematoma
Authors: Yang Feilong , Xu Wuhuan , Tang Xielin , Yang Yan , Ku Buqian A. , Zhang Yiping , Yang Xiaoli , Xie Wei , Hui Xuhui 
Published: October 2024

ObjectiveNeuroendoscopic surgery (NES) has been proven to be safe and effective in hematoma evacuation for cerebral hemorrhage. However, its efficacy for thalamic hemorrhage accompanied by intraventricular hematoma (THAVH) remains unclear. The aim of this study is to determine the efficacy of NES in treating THAVH.MethodA retrospective study was carried out. The data of patients diagnosed with THAVH were collected from January 1st, 2019, to January 1st, 2022. Patients received the NES or external ventricle drainage (EVD) treatment were assigned to the NES or EVD group, respectively. As primary outcomes, the hematoma evacuation volume, residual hematoma volume, and hematoma clearance rate were separately calculated based on the hematoma site; and the 180-day-mRS score was assessed. As secondary outcomes, the length of stay in the ICU and hospital, and the adverse events were also compared.ResultsThirty-five patients, aged 66.37 ± 6.62 years, were in the NES group; and 40 patients, aged 68.75 ± 7.22 years, were in the EVD group. The baseline characteristics in the two groups were similar (P &gt; 0.05). The gross hematoma evacuation volume, volume of hematoma evacuated in the thalamus or the ventricle, and the hematoma clearance rate were greater in the NES group than in the EVD group on the 1st day after surgery (P &lt; 0.05). The patients had a better rank of mRS in the NES group (P &lt; 0.05). Compared with patients with mRS &gt; 3, the mean residual hematoma volume in the thalamus of patients with mRS ≤3 on the 1st and 7th day were less in each group (P &lt; 0.05), respectively. A residual hematoma volume in the ventricle of patients with mRS ≤3 was less than that of patients with mRS &gt;3 in the EVD group on the 1st day after surgery (P &lt; 0.05). GCS score on the 3rd day was greater in the NES group (P &lt; 0.05). The incidence of lung infection was lower in the NES group (P &lt; 0.05). The length of stay in the ICU and hospitalization duration were shorter in the NES group (P &lt; 0.05).ConclusionsNeuroendoscopic surgery has a greater hematoma clearance rate, a lower lung infection rate and a shorter duration in the hospital. Neuroendoscopic surgery might improve patients’ prognosis. Neuroendoscopic surgery is a safe and effective procedure for treating thalamic hemorrhage accompanied by intraventricular hematoma.
Spectrum Broadening Due to Nonselective Linear Absorption
Authors: Zhang Xingchu , She Weilong 
Published: October 2024

The position and linewidth of an emission spectrum reflect the physical properties of the luminophor. So, keeping the spectrum from distortion is very important in its measurement. However, we find that the spectrum linewidth will be broadened when the near-infrared radiation from a sodium lamp passes through a nonselective linear absorbing filter. This counterintuitive linewidth-broadening phenomenon is obvious when the residual light power after the filter is low enough, typically lower than 2.48×10−4 μW. This novel linewidth-broadening effect is different from the well-known Lorentzian, Doppler, and Voigt broadening, and is likely to be more independent evidence of the discrete wavelet structure of classical plane light waves. The effect is significant in high-sensitivity spectroscopy measurements, for example streak camera spectroscopy and Raman spectroscopy experiments. In addition, this effect may also be significant for cosmological research.
Permainan Olahraga Tradisional Lompat Tali Karet
Authors: Saputra Rangga Fadilah , Wijayanti Lisna , Anggraeni Neli , Saadah Sofiah Nurus , Dewi R. Retna Kinanti 
Published: October 2024

Permainan Karet merupakan salah satu permainan tradisional anak Nusantara. Cara bermain lompat tali karet, menggunakan tali yang terbuat dari sambungan karet gelang yang panjangnya kira-kira 5 meter. Kedua ujung karet dipegang oleh dua orang, mereka memutar karet secara bersamaan dan ada satu orang yang melompat-lompat mengikuti gerak naik turun karet tersebut. Observasi ini di lakukan di daerah Telukjame timur, Karawang, Jawa Barat, Indonesia. Dengan populasi 10 orang, dan untuk sampel nya 5 orang, dan cara pengambilan sampel nya yaitu Teknik Accidental Sampling
Implementasi Pendidikan Kesehatan Hand Hygiene dalam Upaya Pencegahan Diare pada Anak Usia Pra Sekolah di PAUD Kuntum Mekar
Authors: Irihadi Tirta , Anggraeni Fitri , Ambarwati Dwi 
Published: October 2024

Diare merupakan defekasi encer yang terjadi lebih dari tiga kali dalam 24 jam. Pendidikan kesehatan adalah kegiatan pembelajaran yang dibangun secara sadar dan mencakup berbagai bentuk komunikasi untuk meningkatkan pemahaman tentang kesehatan. Hand hygiene adalah tindakan membersihkan tangan mengunakan sabun dan air mengalir atau dengan hand sanitizer. Tujuan penelitian ini untuk mengetahui hasil implementasi pendidikan kesehatan hand hygiene dalam upaya pencegahan diare pada anak usia pra sekolah di PAUD Kuntum Mekar. Jenis penelitian ini menggunakan studi kasus deskriptif. Subjek dalam kasus ini sebanyak 4 orang sesuai dengan kriteria inklusi dan eksklusi. Instrumen yang digunakan adalah lembar observasi yang terdiri dari 10 pernyataan tentang langkah-langkah cuci tangan yang baik dan benar. Hasil dari penelitian yang dilakukan sebanyak 2 hari pengambilan data sebelum dilakukan pendidikan kesehatan hand hygiene didapatkan skor rata-rata 4,5 dengan kategori kurang baik dan sesudah dilakukan pendidikan kesehatan hand hygiene didapatkan skor rata-rata 7 dengan kategori baik, skor rata-rata perbandingan sebelum dan sesudah dilakukan pendidikan kesehatan hand hygiene adalah 4,5 : 7 dengan mengalami peningkatan. Kesimpulan penelitian ini adalah implementasi pendidikan kesehatan hand hygiene mampu meningkatkan keterampilan mencuci tangan dalam upaya pencegahan diare pada anak usia pra sekolah di PAUD Kuntum Mekar.

Diarrhea is watery defecation that occurs more than three times in 24 hours. Health education is a learning activity that is built consciously and includes various forms of communication to increase understanding about health. Hand hygiene is the act of cleaning your hands using soap and running water or with a hand sanitizer. The aim of this research is to determine the results of the implementation of hand hygiene health education in efforts to prevent diarrhea in pre-school children at PAUD Kuntum Mekar. This type of research uses descriptive case studies. The subjects in this case were 4 people according to the inclusion and exclusion criteria. The instrument used was an observation sheet consisting of 10 statements regarding the steps for good and correct hand washing. The results of research carried out for 2 days of data collection before the hand hygiene health education was carried out obtained an average score of 4.5 in the poor category and after the hand hygiene health education was carried out an average score of 7 was carried out in the good category, the average score is a comparison before and after hand hygiene health education was 4.5: 7 with an increase. The conclusion of this research is that the implementation of hand hygiene health education is able to improve hand washing skills in an effort to prevent diarrhea in pre-school children at PAUD Kuntum Mekar.
Implementasi Angkle Pump Exercise dengan Elevasi 30 derajat Untuk Mengurangi Edema pada Pasien CKD ON HD Di RSAU Dr.Esnawan Antariksa
Authors: Lukman al hakim  , Harwina Widya Astuti  , Sinta Fresia  
Published: October 2024

Gagal Ginjal Kronik merupakan kondisi seseorang yang mengalami kerusakan fungsi ginjal yang bersifat irreversible yang disebabkan hipertensi, diabetes melitus, penyakit sistemik lain, dan batu saluran kemih. Prevalensi GGK di Provinsi DKI Jakarta sebesar 4,5% di tahun 2018. Salah satu terapi yang digunakan untuk menurunkan sisametabolisme tubuh yaitu terapi Hemodialisis. Tanda dan gejala yang muncul pada pasien dengan terapi Hemodialisis adalah peningkatan beratbadan akibat penumpukan cairan yang ditandai dengan edema. Upaya yang dilakukan untuk mengatasi edema yaitu terapi ankle pump exercisedan elevasi 300. Tujuan penelitian untuk mengetahui gambaran pengaruhimplementasi ankle pump exercise dan elevasi 300 untuk mengurangiedema di Ruang Hemodialisis. Metode penelitian jenis rancanganpenelitian ini adalah deskriptif studi kasus. Subjek studi pada penelitian iniberjumlah 2 subjek. Instrumen yang digunakan adalah lembar observasiedema. Hasil penelitian menunjukkan adanya pengaruh penurunan edema.Edema pada subjek satu sebelum dilakukan intervensi adalah derajat III (4mm), setelah dilakukan intervensi mengalami penurunan menjadi derajatII (2mm). Derajat edema pada subjek dua sebelum dilakukan intervensiadalah derajat III (5mm), setelah dilakukan intervensi mengalamipenurunan menjadi derajat II (2mm). Kesimpulan dari studi kasus iniadalah terapi kombinasi ankle pump exercise dan elevasi 300 pada keduasubjek memberikan pengaruh terhadap penurunan edema pada pasienCKD di ruang Hemodialisis.

Chronic Kidney Failure is a condition of a person who irreversible damage to kidney function caused by hypertension, diabetes mellitus, other systemic diseases, and urinary tract stones. The prevalence of CKD in DKI Jakarta Province was 4.5% in 2018. One of the therapy used to reduce the body's metabolic waste is hemodialysis therapy. Hemodialysis. Signs and symptoms that appear in patients with Hemodialysis therapy is an increase in body weight due to fluid accumulation characterized by edema. with edema. Efforts made to overcome edema are ankle therapy The purpose of the study was to determine the description of the effect of implementing ankle pump exercise and elevation 300 to reduce edema in the Hemodialysis Room. edema in the Hemodialysis Room. Research method this type of research design is a descriptive case study. The study subjects in this study amounted to 2 subjects. The instrument used was an edema observation sheet. The results showed a decrease in edema. Edema in subject one before the intervention was degree III (4mm), after the intervention decreased to degree II (2mm). The degree of edema in subject two before the intervention was degree III (5mm), after the intervention decreased to degree II (2mm). intervention decreased to degree II (2mm). The conclusion of this case study is that the combination of ankle pump exercise and elevation therapy 30° in both subjects has an effect on reducing edema in patients with COPD.
DIAGNÓSTICO E MANEJO DA HIPERTENSÃO PULMONAR
Authors: Anne Karoline Tomé Briglia  , Maria Carolina de Oliveira  , Larissa Silva Guimaraes  , Rafael Ruschel Rodrigues  , Victória André de Magalhães  , João Vitor Kravzuk Gomez  , Luiza Racim Munhoz  , Ariele Cristina Souza Santos  , Beatriz Barros Rasia  , Natalia Rodrigues Fagundes  
Published: October 2024

A hipertensão pulmonar pode ser causada por várias patologias como doenças cardíacas, pulmonares e condições hereditárias ou idiopáticas. Sua fisiopatologia de forma geral é caracterizada pelo aumento da pressão arterial nas artérias que levam sangue aos pulmões. Pode ser diagnosticado através de exames como raio-x ecocardiograma, cateterismo cardíaco. A abordagem depende da causa subjacente e da gravidade da doença, mas pode incluir medicamentos vasodilatadores, anticoagulantes e oxigenoterapia. Este estudo trata-se de uma revisão sistemática de literatura com o objetivo de descrever o diagnóstico e manejo da hipertensão pulmonar.
The fate of Krakow’s builders and architectus of Jewish origin in the face of World War II. Possibilities of applying the micro-historical method in research on architecture and urban planning
Authors: Motak Maciej 
Published: October 2024

This article is about the fate of a group of architects and builders in Krakow during World War II. After the outbreak of the war and the start of the German occupation in September 1939, they found themselves in a very difficult position. As the persecution intensified, so did the opportunities for their professional activities strongly diminish, although they did not disappear. The article outlines in more detail two individual situations – those of Samuel Mehl and Jakub Stendig – one related to the creation of a building, the other to, among other issues, the loss of a building. The research used methods often applied in the studies in architecture and urbanism: literaturę analysis, search in archives, field research. The micro-historical method, which is rather rarely used in such research, was also applied. This method, which has been used for nearly 50 years in scientific, mainly historical research, is based on studying and preserving the individual element of the narrative while aiming to generalise the result.
In spite of the extremely cruel persecution of the Jewish population in Krakow during World War II, some architects and builders of Jewish origin continued their professional activity under various and difficult conditions. Its forms varied from design work and construction of residential buildings, to care for historical monuments, to construction activity in a concentration camp. Professional activity and specific skills may have contributed to the fact that proportionally more Jewish architects and builders survived the Holocaust than the Jewish community in Krakow as a whole. The consequences of the Holocaust for the architecture and space of Krakow were serious and varied: the loss of an important professional group, the loss of valuable architectural and artistic works, the change of features in newly designed buildings. The legacy of the work of architects and builders of Jewish origin in Krakow is very significant. It has been commemorated in a variety of tangible and intangible forms, although insufficiently in proportion to its scale.
Pavlovian impatience: The anticipation of immediate rewards increases approach behaviour
Authors: Burghoorn Floor , Scheres Anouk , Monterosso John , Guo Mingqian , Luo Shan , Roelofs Karin , Figner Bernd 
Published: October 2024

AbstractPeople often exhibit intertemporal impatience by choosing immediate small over delayed larger rewards, which has been implicated across maladaptive behaviours and mental health symptoms. In this preregistered study, we tested the role of an intertemporal Pavlovian bias as possible psychological mechanism driving the temptation posed by immediate rewards. Concretely, we hypothesized that the anticipation of immediate rewards (compared with preference-matched delayed rewards) enhances goal-directed approach behaviour but interferes with goal-directed inhibition. Such a mechanism could contribute to the difficulty to inhibit ourselves in the face of immediate rewards (e.g., a drug), at the cost of long-term (e.g., health) goals. A sample of 184 participants completed a newly developed reinforcement learning go/no-go task with four trial types: Go to win immediate reward; Go to win delayed reward; No-go to win immediate reward; and No-go to win delayed reward trials. Go responding was increased in trials in which an immediate reward was available compared with trials in which a preference-matched delayed reward was available. Computational models showed that on average, this behavioural pattern was best captured by a cue-response bias reflecting a stronger elicitation of go responses upon presentation of an immediate (versus delayed) reward cue. The results of this study support the role of an intertemporal Pavlovian bias as a psychological mechanism contributing to impatient intertemporal choice.
Evaluation of Circulating Tumor DNA and Carcinoembryonic Antigen Levels and Relationship with Clinicopathological Risk Factors and Prognostic Indices in Colorectal Cancer Patients
Authors: YASLIKAYA Şendağ , TÜRKER Mehmet , AYDINALP CAMADAN Yasemin , KIDI Mehmet Mutlu , BİTER Sedat , ASARKAYA Esra , ASOĞLU RÜZGAR Hatice , ATAŞ İPEK Şüheda , KARA İ.Oğuz , ŞAHİN Berksoy 
Published: October 2024

Objective: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. ctDNA has emerged as a promising biomarker for CRC management, offering real-time insights into tumor burden and genetic mutations. This study investigates the correlation between CEA levels, ctDNA, clinicopathological factors, and treatment outcomes in early and advanced CRC patients.
Methods: The study retrospectively analyzed data from CRC patients, including early-stage disease and metastatic disease. ctDNA levels, demographic data, and clinical parameters such as CEA, inflammatory indexes, and tumor characteristics were evaluated to determine correlations with treatment outcomes.
Results: The study included 20 patients, with 60% diagnosed at the metastatic stage. The study found no statistically significant correlation between ctDNA levels and disease stage, recurrence, or overall survival. While CEA and ctDNA levels were measured, they did not demonstrate a significant relationship with treatment outcomes. Notably, ctDNA levels were higher in metastatic patients, though this was not statistically significant.
Conclusion: Despite its potential, the integration of ctDNA as a routine biomarker in CRC care faces challenges, including variability in measurement techniques and cost-effectiveness. However, ctDNA's ability to guide personalized treatment strategies and monitor disease recurrence holds promise. The study's findings align with previous research, suggesting ctDNA as a poor prognostic indicator, though further research is needed. ctDNA represents a significant advance in CRC management, offering non-invasive, real-time insights into tumor dynamics. Ongoing research is expected to solidify its role in personalized treatment planning, potentially leading to more effective and tailored therapies for CRC patients.
Hemoglobinopathy Awareness Among Middle and High School Students In Karataş, Türkiye
Authors: Nazlıcan Ersin , Akbaba Muhsin 
Published: October 2024

Objective:Hemoglobinopathies are complex and inherited genetic disorders with no definitive cure; however, preventive measures such as genetic counseling and premarital screening may dramatically reduce their prevalence. Therefore, having sufficient information about the mentioned preventive measures is crucial.
Methods:All students attending middle and high schools were included without a sample selection. A survey form was administered to students in order to evaluate their knowledge level and attitudes regarding hemoglobinopathies. The results were evaluated using Chi-square and logistic regression analysis with 95% confidence interval (CI).
Results:The total number of students agreeing to participate in the study was 877. The mean age of the participants was 14.8 ± 1.5 years; 50.5% of them were male.Of the participating students, 40.3% were previously informed about hemoglobinopathies.The lowest correct response rate among questions in terms of students’ knowledge about hemoglobinopathies was observed in the question that asked the transmission route of the disorders with 13.7%.In the multivariate analysis, maternal education level (OR=1.417; 95% CI) and knowing an affected patient (OR=4.215; 95% CI) were associated with a greater likelihood of being previously informed.
Conclusions:Our study demonstrated that students had insufficient knowledge on hemoglobinopathies in a region where the disorders are prevalent. Organizing and sustaining educational activities related to hemoglobinopathies - particularly genetic basics of the disorders - to students, who are the parents of the future, may be useful in combating hemoglobinopathies.

Keywords:Hemoglobinopathies, Awareness, School Health, Middle School Students, High School Students