bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Temperature and Salinity on Early Ontogeny of Bigmouth Sleeper Larvae
Authors: Olivieri-Velázquez Karina M , Neal J Wesley 
Published: February 2018

Abstract
Declines in the abundance of Bigmouth Sleeper Gobiomorus dormitor within its range warrant directed conservation efforts, which may include population supplementation with hatchery-produced fish. However, previous attempts at Bigmouth Sleeper culture resulted in limited larval development and lack of successful exogenous feeding after yolk sac depletion, presumably in response to environmental conditions. The effects of temperature and salinity on hatch success, survival, growth, and development of Bigmouth Sleeper yolk sac larvae were examined in controlled, replicated experiments. Hatch success was greater at lower temperatures (23°C) and salinities (0, 5, and 10 g/L), larvae survived longer at lower temperatures (23 and 26°C), and growth metrics were greatest in freshwater (salinity = 0 g/L). Larvae held at salinities of 5 g/L and higher experienced 100% mortality within 12 h posthatch. Survival and development were inversely correlated and dependent on temperature; survival was greater at 23°C, but larvae developed slowly, while development was rapid at 29°C, yet all fish died by 48 h posthatch. The results suggests that the optimal hatching temperature and salinity for Bigmouth Sleeper is 23°C and 0 g/L, respectively, and the optimum rearing temperature for yolk sac larvae is 26°C. However, the amphidromous life history strategy of this species may require an increasing temperature and salinity regimen that mimics the environmental conditions larvae would experience following hatch during downstream transport from cooler freshwater streams to warmer brackish and marine waters in their natural habitats.
Risk of Malnutrition Evaluated by Mini Nutritional Assessment and Sarcopenia in Noninstitutionalized Elderly People
Authors: Liguori Ilaria , Curcio Francesco , Russo Gennaro , Cellurale Michele , Aran Luisa , Bulli Giulia , Della‐Morte David , Gargiulo Gaetano , Testa Gianluca , Cacciatore Francesco , Bonaduce Domenico , Abete Pasquale 
Published: February 2018

AbstractBackgroundMalnutrition indices and muscle mass and strength in the elderly are poorly investigated. Moreover, malnutrition seems to be 1 of the more important factors in the cause of sarcopenia. The presence of sarcopenia and its relationship with malnutrition indices were studied in noninstitutionalized elderly people who underwent Comprehensive Geriatric Assessment (CGA).MethodsA total of 473 elderly subjects (mean age, 80.9 ± 6.6 years) admitted to CGA were studied. Malnutrition risk was evaluated with Mini Nutritional Assessment (MNA) score, whereas muscle mass and muscle strength were evaluated by bioimpedentiometry and hand grip, respectively. Sarcopenia was assessed as indicated in the European Working Group on Sarcopenia in Older People (EWGSOP) consensus.ResultsOverall prevalence of sarcopenia was 13.1%, and it increased from 6.1% to 31.4% as MNA decreased (P < .001). MNA score was lower in elderly subjects with sarcopenia (15.4 ± 4.2) than without sarcopenia (22.0 ± 4.0) (P = .024). Linear regression analysis showed that MNA score is linearly related both with muscle mass (r = 0.72; P < .001) and strength (r = 0.42; P < .001). Multivariate analysis, adjusted for several confounding variables including comorbidity and disability, confirmed these results.ConclusionsMNA score is low in noninstitutionalized elderly subjects with sarcopenia, and it is linearly related to muscle mass and muscle strength. These data indicate that MNA score, when evaluated with muscle mass and strength, may recognize elderly subjects with sarcopenia.
Variable prenatal presentation of Pfeiffer syndrome: Suggested aids to prenatal sonographic diagnosis
Authors: Saliba Souha , Morel Baptiste , Gonzales Marie , Sénat Marie‐Victoire , Guilbaud Lucie , Jouannic Jean‐Marie , Cassart Marie , Garel Catherine , Blondiaux Eléonore 
Published: February 2018

AbstractBackgroundOur purpose was to describe and compare the cranial and extracranial abnormalities of Pfeiffer syndrome on prenatal imaging with postnatal or postmortem findings, which may help in prenatal diagnosis of Pfeiffer syndrome (PS).MethodsCases of fetuses with a confirmed diagnosis of PS over a 4‐year period (2012–2016) were retrospectively reviewed. Prenatal imaging findings, postnatal, or postmortem investigations and genetic test results were analyzed.ResultsFour fetuses were ascertained, 3 with prenatal sonographic findings compatible with PS and one only diagnosed at postmortem. Cases were referred between 22 and 24 weeks' gestation. Three of the 4 cases were terminated, and details of postmortem/postnatal examination were available in all. There was variable presentation of features. Craniosynostosis was present in 3 cases, but only detected prenatally in 2. Extracranial signs included abnormalities of thumbs and/or big toes, detected prenatally in 3 of the 4 cases. A sacral appendage and vertebral or coronal clefts were present at postmortem in 3 cases but only detected prenatally in one. A cartilaginous tracheal sleeve was detected at postmortem in all 3 cases but not detected by prenatal ultrasound. Other findings included ventriculomegaly, posterior fossa, and facial anomalies. Molecular testing revealed mutations of the fibroblast growth factor receptor 2 (FGFR2) gene in all cases.ConclusionPfeiffer syndrome has a highly variable phenotype, and the absence of craniosynostosis on prenatal US does not exclude the diagnosis. Presence of abnormal thumbs and big toes, a sacral appendage, vertebral fusions, and coronal clefts should lead to prenatal molecular testing for PS.
When ultrasound anomalies are present: An estimation of the frequency of chromosome abnormalities not detected by cell‐free DNA aneuploidy screens
Authors: Reimers Rebecca M. , Mason‐Suares Heather , Little Sarah E. , Bromley Bryann , Reiff Emily S. , Dobson Lori J. , Wilkins‐Haug Louise 
Published: February 2018

AbstractObjectivesThis study characterizes cytogenetic abnormalities with ultrasound findings to refine counseling following negative cell‐free DNA (cfDNA).MethodsA retrospective cohort of pregnancies with chromosome abnormalities and ultrasound findings was examined to determine the residual risk following negative cfDNA. Cytogenetic data was categorized as cfDNA detectable for aneuploidies of chromosomes 13, 18, 21, X, or Y or non‐cfDNA detectable for other chromosome abnormalities. Ultrasound reports were categorized as structural anomaly, nuchal translucency (NT) ≥3.0 mm, or other “soft markers”. Results were compared using chi squared and Fishers exact tests.ResultsOf the 498 fetuses with cytogenetic abnormalities and ultrasound findings, 16.3% (81/498) had non‐cfDNA detectable results. In the first, second, and third trimesters, 12.4% (32/259), 19.5% (42/215), and 29.2% (7/24) had non‐cfDNA detectable results respectively. The first trimester non‐cfDNA detectable results reduced to 7.7% (19/246) if triploidy was detectable by cfDNA testing. For isolated first trimester NT of 3.0–3.49 mm, 15.8% (6/38) had non‐cfDNA detectable results, while for NT ≥3.5 mm, it was 12.3% (20/162). For cystic hygroma, 4.3% (4/94) had non‐cfDNA detectable results.ConclusionsCounseling for residual risk following cfDNA in the presence of an ultrasound finding is impacted by gestational age, ultrasound finding, and cfDNA detection of triploidy.
Fetal Doppler changes 1 week after endoscopic equatorial laser for twin‐to‐twin transfusion syndrome: A longitudinal study
Authors: Persico Nicola , D'Ambrosi Francesco , Fabietti Isabella , Boito Simona , Aiello Elisa , Bulfoni Alessandro , Ciralli Fabrizio , Kustermann Alessandra , Mosca Fabio , Fedele Luigi 
Published: February 2018

AbstractObjectiveTo investigate sequential Doppler changes in donors and recipients before and 1 week after endoscopic laser for twin‐to‐twin transfusion syndrome (TTTS) and to examine factors that may be associated with such changes.MethodsIn TTTS pregnancies undergoing laser treatment, we examined fetal Doppler changes before and 1 week postintervention. Intrauterine death rates and preoperative factors were analyzed in relation to Doppler changes.ResultsAmong 129 (85.4%) donors surviving at 1 week after laser, there was normalization of umbilical artery flow in 26 (72.2%) of 36 cases with preoperative abnormal Dopplers. In the remaining 10 (27.8%) fetuses, abnormal findings persisted. The rate of later intrauterine death was significantly higher in the latter group (6 of 10, 60.0%) compared with fetuses in which Doppler findings normalized (4 of 26, 15.4%; P < .05), with no difference in the rate of severe donor growth restriction between the 2 groups (80.0% vs 65.4%, respectively; P = .688).ConclusionsIn about 70% of TTTS donors with preoperative abnormal umbilical artery Doppler, there was normalization 1 week after endoscopic laser. The incidence of fetal growth restriction was not significantly different in donors with persistence of Doppler abnormalities compared with those with normalized findings.
Influences of the grafting percentage of natural rubber‐graft‐poly(2‐hydroxyethyl acrylate) on properties of its vulcanizates
Authors: Chueangchayaphan Wannarat , Chueangchayaphan Narong , Tanrattanakul Varaporn , Muangsap Suchanya 
Published: February 2018

AbstractThe graft copolymerization of 2‐hydroxyethyl acrylate (HEA) monomer onto natural rubber (NR) latex was successful using cumene hydroperoxide and tetraethylene pentamine as redox initiators. The grafting of poly(2‐hydroxyethyl acrylate) (PHEA) on the NR particles was confirmed by Fourier transform infrared spectroscopy, 1H NMR spectroscopy and TEM. The NR‐g‐PHEA with various grafting percentages (0%, 8.7%, 14.3% and 18.7%) was compounded on a two‐roll mill with a sulfur vulcanization system. The effects of grafting percentage on the cure characteristics, dielectric properties, thermal properties and physical properties of NR‐g‐PHEA vulcanizates were investigated. It was found that increased grafting caused NR‐g‐PHEA vulcanizates to have reduced water contact angle, scorch time and cure time, while the dielectric constant and dissipation factor increased. The NR‐g‐PHEA vulcanizate with 8.7% grafting exhibited the highest delta torque (MH − ML), crosslink density, tensile strength, moduli at 100%, 200% and 300% strains, and hardness, with insignificant loss of elongation at break in comparison to the other cases. © 2018 Society of Chemical Industry
Mindfulness‐based SEL programming to increase preservice teachers’ mindfulness and emotional competence
Authors: Garner Pamela W. , Bender Stacy L. , Fedor Megan 
Published: February 2018

AbstractEighty‐seven preservice teachers, some of whom had preschool teaching experience, were randomly assigned to an intervention that included training in breathing awareness meditation infused with social‐emotional learning (n = 43) or a control group that received training in (n = 44) in breathing awareness meditation only. Both groups showed an increase in mindfulness from pre‐ to posttest. However, as expected, dimensions of emotional competence improved more significantly for preservice teachers in the intervention group. Increases were also greater for participants with teaching experience. Both groups also increased in the belief that classroom misbehavior would result in negative cognitive and social costs to children, but a larger increase was observed for the intervention group. Implications for teacher preparation are discussed.
Identification of Native and Posttranslationally Modified HLA‐B*57:01‐Restricted HIV Envelope Derived Epitopes Using Immunoproteomics
Authors: Ramarathinam Sri H. , Gras Stephanie , Alcantara Sheilajen , Yeung Amanda W.S. , Mifsud Nicole A. , Sonza Secondo , Illing Patricia T. , Glaros Elias N. , Center Robert J. , Thomas Shane R. , Kent Stephen J. , Ternette Nicola , Purcell Damian F. J. , Rossjohn Jamie , Purcell Anthony W. 
Published: February 2018

AbstractThe recognition of pathogen‐derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antigens are degraded in the cytosol and short peptides assemble with class I human leukocyte antigen (HLA) molecules in the ER. These peptide‐HLA complexes egress to the cell surface and are scrutinized by cytotoxic CD8+ T‐cells leading to the eradication of the infected cell. Here, naturally presented HLA‐B*57:01 bound peptides derived from the envelope protein of the human immunodeficiency virus (HIVenv) are identified. HIVenv peptides are present at a very small percentage of the overall HLA‐B*57:01 peptidome (<0.1%) and both native and posttranslationally modified forms of two distinct HIV peptides are identified. Notably, a peptide bearing a natively encoded C‐terminal tryptophan residue is also present in a modified form containing a kynurenine residue. Kynurenine is a major product of tryptophan catabolism and is abundant during inflammation and infection. Binding of these peptides at a molecular level and their immunogenicity in preliminary functional studies are examined. Modest immune responses are observed to the modified HIVenv peptide, highlighting a potential role for kynurenine‐modified peptides in the immune response to HIV and other viral infections.
Design of cyclic and d‐amino acids containing peptidomimetics for inhibition of protein‐protein interactions of HER2‐HER3
Authors: Pallerla Sandeep , Naik Himgauri , Singh Sitanshu , Gauthier Ted , Sable Rushikesh , Jois Seetharama D. 
Published: February 2018

HER2 receptors are surface proteins belonging to the epidermal growth factor family of receptors. Their numbers are elevated in breast, lung, and ovarian cancers. HER2‐positive cancers are aggressive, have higher mortality rate, and have a poor prognosis. We have designed peptidomimetics that bind to HER2 and block the HER2‐mediated dimerization of epidermal growth factor family of receptors. Among these, a symmetrical cyclic peptidomimetic (compound 18) exhibited antiproliferative activity in HER2‐overexpressing lung cancer cell lines with IC50 values in the nanomolar concentration range. To improve the stability of the peptidomimetic, d‐amino acids were introduced into the peptidomimetic, and several analogs of compound 18 were designed. Among the analogs of compound 18, compound 32, a cyclic, d‐amino acid‐containing peptidomimetic, was found to have an IC50 value in the nanomolar range in HER2‐overexpressing cancer cell lines. The antiproliferative activity of compound 32 was also measured by using a 3D cell culture model that mimics the in vivo conditions. The binding of compound 32 to the HER2 protein was studied by surface plasmon resonance. In vitro stability studies indicated that compound 32 was stable in serum for 48 hours and intact peptide was detectable in vivo for 12 hours. Results from our studies indicated that 1 of the d‐amino acid analogs of 18, compound 32, binds to the HER2 extracellular domain, inhibiting the phosphorylation of kinase of HER2.
Preparedness for slow‐onset environmental disasters: Drawing lessons from three decades of El Niño impacts
Authors: Staupe‐Delgado Reidar , Kruke Bjørn Ivar , Ross Robert J. , Glantz Michael H. 
Published: February 2018

AbstractEl Niño warm events provide a fruitful case for the study of disaster‐induced learning due to their reoccurring nature and the high level of uncertainty surrounding their impacts. The purpose of this study is to elucidate impediments and opportunities for learning from El Niño disaster planning. To achieve this, we analyse and compare two lessons learned reports from the 1997–98 and 2015–16 El Niño events. These reports also refer to the 1982–83 El Niño event, providing a longer case‐record. The findings suggest that inter‐event learning is facilitated by the existence of at least three key elements: the presence of national research programmes on El Niño mechanics and forecast capability; a development approach to disaster risk reduction, where root causes such as poverty and socio‐economic exclusion are considered, and the availability of media channels that refrain from sensationalist framing in favour of relevant and useful messages regarding appropriate mitigative strategies. Unfavourable learning conditions were identified as those characterized by a lack of political will, reliance on reactive response strategies and a lack of inter‐agency coordination.
Outcomes of Penetrating Keratoplasty Following Autologous Cultivated Limbal Epithelial Stem Cell Transplantation
Authors: Figueiredo Gustavo S. , Salvador-Culla Borja , Baylis Oliver J. , Mudhar Hardeep S. , Lako Majlinda , Figueiredo Francisco C. 
Published: February 2018

Abstract
The purpose of this study is to investigate the outcomes of penetrating keratoplasty (PKP) following autologous cultivated limbal epithelial stem cell transplantation (CLET). A prospective, single center, interventional cohort study investigating patients with unilateral total limbal stem cell deficiency (LSCD) treated with CLET who underwent PKP. Patients with confirmed corneal re-epithelialization &gt; 6 months post-CLET, and with best-corrected visual acuity (BCVA) &lt;0.3 logMAR were offered PKP. CLET survival assessed by slit lamp, corneal impression cytology (CIC), and in vivo confocal microscopy. Confirmation of corneal re-epithelialization by histological and immunocytochemical (ICC) examination of trephined corneal buttons. Mean change in best-corrected visual acuity (logMAR) following PKP and PKP survival at 12 months were calculated. Twenty patients underwent PKP. Mean time of PKP was 19 months (range 11–41 months, SD 7.26) post-CLET. Median follow-up time post-PKP was 15 months (range 1–32, SD 10.2). CIC and ICC of all corneas confirmed corneal re-epithelialization before PKP. Mean pre-PKP BCVA was 1.46 (range 0.3–2.7, SD 0.94) improving to a mean post-PKP BCVA of 0.74 (range 0–2.7, SD 0.87); mean improvement in BCVA post-PKP of 36 letters (95% CI 15.0–57.1, p = .002). Kaplan-Meier mean graft survival was 90.9% (95% CI 50.8–98.7) at 12 months. We recommend a two-stage approach with CLET followed by PKP &gt;12 months later. Patients experienced a significant improvement in BCVA following PKP. PKP did not have a detrimental effect on CLET survival. PKP survival post-CLET is better than that reported for high risk PKP.
Effiziente Herstellung von Kohlenstofffasern
Authors: Mager Alexander , Kloiber Verena , Lehmann Beata , Köckritz Tilo , Roch Julius , Großmann Jane , Mäder Gerrit , Beyer Eckhard , Kaskel Stefan 
Published: February 2018

SummaryEfficient production of carbon fibres using new technologiesInnovative process technologies for carbonization of precursor fibres, which can substitute conventional oven technologies and raise the efficiency of carbon fibre production are presented. The process technologies are based on the substitution of convective heat transfer by microwave plasma or direct fiber heating. In microwave‐assisted plasma treatment, the heating of the fibres is carried out both by microwave absorption in the fibre volume and energy input into the fibre surface by means of the plasma species. During electrical carbonization, the fibres are heated by means of an electrical current flow. The processes can be used separately, one after the other (also in combination with conventional furnace technology) or as hybrid processes.
Disability Weights for Pediatric Surgical Procedures: A Systematic Review and Analysis
Authors: Smith Emily R. , Concepcion Tessa , Lim Stephanie , Sadler Sam , Poenaru Dan , Saxton Anthony T. , Shrime Mark , Ameh Emmanuel , Rice Henry E. ,   Global Initiative for Children’s Surgery
Published: February 2018

AbstractBackgroundMetrics to measure the burden of surgical conditions, such as disability weights (DWs), are poorly defined, particularly for pediatric conditions. To summarize the literature on DWs of children’s surgical conditions, we performed a systematic review of disability weights of pediatric surgical conditions in low‐ and middle‐income countries (LMICs).MethodFor this systematic review, we searched MEDLINE for pediatric surgery cost‐effectiveness studies in LMICs, published between January 1, 1996, and April 1, 2017. We also included DWs found in the Global Burden of Disease studies, bibliographies of studies identified in PubMed, or through expert opinion of authors (ES and HR).ResultsOut of 1427 publications, 199 were selected for full‐text analysis, and 30 met all eligibility criteria. We identified 194 discrete DWs published for 66 different pediatric surgical conditions. The DWs were primarily derived from the Global Burden of Disease studies (72%). Of the 194 conditions with reported DWs, only 12 reflected pre‐surgical severity, and 12 included postsurgical severity. The methodological quality of included studies and DWs for specific conditions varied greatly.InterpretationIt is essential to accurately measure the burden, cost‐effectiveness, and impact of pediatric surgical disease in order to make informed policy decisions. Our results indicate that the existing DWs are inadequate to accurately quantify the burden of pediatric surgical conditions. A wider set of DWs for pediatric surgical conditions needs to be developed, taking into account factors specific to the range and severity of surgical conditions.
Estudo retrospectivo dos resultados do tratamento cirúrgico de 31 tumores de células gigantes da bainha do tendão da mão
Authors: Galbiatti José , Milhomens Gabriel , Silva Luís , Santiago Diego , Silva Neto José , Belluci Sérgio 
Published: February 2018

ResumoAvaliar os resultados do tratamento de 31 tumores de células gigantes da bainha do tendão da mão encontrados entre 2006 e 2015.Entre fevereiro de 2006 e novembro de 2015, um grupo de pacientes foi selecionado para avaliação retrospectiva, na qual foram estudados e avaliados 31 prontuários de pacientes submetidos a procedimento cirúrgico devido a tumor de células gigantes da bainha do tendão dos dedos da mão. O tratamento preconizado foi a excisão completa do tumor com a preservação das estruturas adjacentes. A confirmação diagnóstica foi feita pelo exame anatomopatológico. Foi avaliada a evolução do tratamento após a cirurgia, principalmente no tocante ao índice de recidivas dos tumores.Dos 31 pacientes da amostra, houve predomínio do sexo feminino e da etnia branca. O tumor acometeu principalmente indivíduos entre 30 e 50 anos. O lado mais acometido foi o esquerdo, e a maioria dos tumores estava na face flexora. Houve predominância dos dedos radiais, juntamente com sua extremidade distal. Esses pacientes têm sido acompanhados em intervalos regulares em ambulatório. Dos 27 pacientes reavaliados, foram identificados 3 casos de recidiva tumoral.Uma técnica cirúrgica adequada é essencial para a prevenção de recidivas do TCGBT. Os resultados obtidos na pesquisa estão em concordância com a literatura atual.