bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Epitope-based Vaccine Design for California Encephalitis Virus(Cev) : a Computational Study Targeting Membrane Glycoproteins
Authors: Surendra Grandhi , Nelluri Kanaka Durga Devi , Male* CH K V L S N Anjana , Kamepalli Sahithi , Sharma Ashish Kumar , Nathiya Deepak , Singh Ravindra Pal , Alaparthi Bhavana , Kommoju Minakshi 
Published: November 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Minimization of complete awaiting duration of wood logs in pulping of paper on multi-stage flow shop scheduling including transportation time and task block
Authors: Sharma Malvika , Gupta Deepak 
Published: November 2024

Abstract

The paper demonstrates different sizes of wood logs are working on multistage flow shop scheduling problem in which stations are placed far away from each other, so transportation period is being associated between every two stations and due to a demand, the task block is used in the problem. The goal is to obtain the optimal sequence to minimize complete awaiting duration of pulping of paper on m stations. Thus, algorithm is supported with a numerical.
Identification of candidate genes associated with resistance to aflatoxin production in peanut through genetic mapping and transcriptome analysis
Authors: Huai Dongxin , Huang Li , Xue Xiaomeng , Yu Bolun , Ding Yingbin , Jin Gaorui , Liu Hao , Pandey Manish K. , Sudini Hari Kishan , Luo Huaiyong , Zhou Xiaojing , Liu Nian , Chen Weigang , Yan Liying , Chen Yuning , Wang Xin , Wang Qianqian , Kang Yanping , Wang Zhihui , Chen Xiaoping , Jiang Huifang , Lei Yong , Liao Boshou 
Published: November 2024

Abstract

Peanut (Arachis hypogaea L.) is a globally significant oil and economic crop, serving as a primary source of edible oil and protein. Aflatoxin contamination is a main risk factor for peanut food safety and industry development worldwide. The most cost-economic and effective control strategy entails the exploration and utilization of natural resistance in peanut, alongside the development of resistant varieties. However, the underlying mechanism of resistance to aflatoxin production (AP) in peanuts remains elusive. In this study, a RIL population derived from a cross between Zhonghua 10 (susceptible) and ICG 12625 (resistant), was used to identify quantitative trait loci (QTLs) for AP resistance. Overall, seven QTLs associated with AP resistance were mapped on five chromosomes, explaining 6.83%~17.86% of phenotypic variance (PVE). Notably, only two major QTLs, namely qAftA07and qAftB06.2, were consistently detected across different environments with 6.83%~16.52% PVE. To predict the candidate genes for AP resistance in qAftA07and qAftB06.2, the transcriptome analysis of seeds from parental lines inoculated with Aspergillus flavus were conducted. A total of 175 and 238 candidate genes were respectively identified in qAftA07 and qAftB06.2, encompassing genes with non-synonymous genomic variations as well as differentially expressed genes (DEGs). Combined with the weighted gene co-expression network analysis (WGCNA), 10 and 11 genes in qAftA07 and qAftB06.2 were characterized showing a high correlation with aflatoxin content, thereby representing the most promising candidate genes within these two QTLs. These results provide valuable insights for future map-based cloning studies targeting candidate genes associated with AP resistance in peanut.
Stakeholder Perspectives of Maternal and Newborn Health Prioritization in South Sudan
Authors: Alier Kon Paul , Kozuki Naoko , Mothupi Mamothena 
Published: November 2024

Abstract

Background
The maternal and neonatal mortality in South Sudan is among the highest in the world and among other fragile and conflict-affected countries. Within an evolving political economic context, this study aims to capture perspectives of current actors on drivers of the stagnating investments in maternal and newborn health (MNH).
Methods
A descriptive case study guided by the health policy analysis triangle to explore contextual factors, policy content, actors’ roles and implementation processes for MNH policy and practice. A total of 20 key informants from government, humanitarian and development organizations, civil society, donors and health providers were interviewed.
Results
According to respondents, MNH was a priority in South Sudan due to the presence of various legal and policy frameworks. However, financial investment in MNH programs was inadequate due to the government focus on peace and stabilization, and the fragmented parallel systems run by international actors. Funding for MNH was also affected by ongoing conflicts and disease outbreaks, which diverted attention away from the issue. National initiatives to expand service coverage and funding are either inadequate or not well studied. In addition, gendered attitudes and norms continue to impede care seeking, service provision and inclusivity in decision-making for improving MNH prioritization. Stakeholders highlighted the need for accountability to sustain progress and close policy implementation gaps.
Conclusion
This study highlighted relevant challenges and opportunities for improving MNH outcomes in South Sudan and similar fragile contexts. Government ownership of the MNH agenda is needed, so is strengthening of national initiatives, gender equity, actor coordination and accountability mechanisms.
The immune-related gene CD5 is a prognostic biomarker associated with the tumor microenvironment of breast cancer
Authors: Zhao Yi , Zhang Hengheng , Wang Wenwen , Shen Guoshaung , Wang Miaozhou , Liu Zhen , Zhao Jiuda , Li Jinming 
Published: November 2024

Abstract

The occurrence and progression of breast cancer (BCa) are complex processes involving multiple factors and multiple steps. The tumor microenvironment (TME) plays an important role in this process, but the functions of immune components and stromal components in the TME require further elucidation. In this study, we obtained the RNA-seq data of 1086 patients from The Cancer Genome Atlas (TCGA) database. We calculated the proportions of tumor-infiltrating immune cells (TICs) and immune and stromal components using the CIBERSORT and ESTIMATE methods, and we screened differentially expressed genes (DEGs). Univariate Cox regression analysis of overall survival was performed on the DEGs, and a protein–protein interaction network of their protein products was generated. Finally, the hub gene CD5 was obtained. High CD5 expression was found to be associated with longer survival than low expression. Gene set enrichment analysis showed that DEGs upregulated in the high-CD5 expression group were mainly enriched in tumor- and immune-related pathways, while those upregulated in the low-expression group were enriched in protein export and lipid synthesis. TIC analysis showed that CD5 expression was positively correlated with the infiltration of CD8+ T cells, activated memory CD4+ T cells, gamma delta T cells, and M1 macrophages and negatively correlated with the infiltration of M2 macrophages. CD5 can increase anticancer immune cell infiltration and reduce M2 macrophage infiltration. These results suggest that CD5 is likely a potential prognostic biomarker and therapeutic target, providing novel insights into the treatment and prognostic assessment of BCa.
Revolutionizing Forest Fire and Smoke Detection: A Cutting-Edge Ensemble of Deep Learning Models for Enhanced Accuracy
Authors: Faheem Mohammad , Ranjan Ashish , Singh Vibhav Prakash 
Published: November 2024

Abstract

Forest fires pose a significant environmental threat, necessitating early and accurate detection systems. This paper addresses the problem of forest fire and smoke detection using an ensemble of deep learning models. Three advanced convo-lutional neural network architectures—DenseNet, ResNet, and Xception—were employed and combined using a majority voting scheme to enhance detection accuracy. Two datasets were utilized: one containing only fire images and another comprising both fire and smoke images. The ensemble model consistently performed better than individual models, with accuracy on the fire and fire and smoke datasets of 0.99 and 0.984, respectively. The findings show that the ensemble method offers a robust and dependable option for early forest fire detection by significantly enhancing detection performance.
Factors Associated with Delayed Referrals of Patients with Sepsis from Primary to Tertiary Healthcare in Blantyre, Malawi: A Qualitative Study
Authors: Kaimba Sylvester , umar Eric 
Published: November 2024

Abstract

Background
Sepsis is a significant global health problem, particularly in low- and middle-income countries. Sepsis is a life-threatening condition that requires prompt identification and early definitive medical intervention. Globally, sepsis is common, with estimated 31.5 million cases per year. Sepsis accounts for a significant in-hospital mortality rate of 17% in high-income countries while in Malawi, it ranges from 17–50%. For Malawi, the trend can be reversed with improvements in patient referral system within the healthcare system. The study set out to establish the referral pathway of patients with sepsis from primary healthcare to tertiary hospitals and to understand healthcare workers and patients’ perspectives on barriers associated with delayed referral of patients with sepsis from primary to tertiary healthcare.
Methods
A qualitative descriptive study in six health centres within Blantyre District health office included 22 face-to-face semi-structured interviews with purposively selected patients recovering from sepsis and with healthcare workers.
Results
The study revealed that the main referral pathways for patients with sepsis include community-to-facility and facility-to-facility referrals. Ambulances and personal transport are common transportation mode used during referrals. Primary care facilities face several challenges that delay referrals from primary to tertiary health facility of patients with sepsis, such as lack of referral transport, poor communication, poor road network, shortage of skilled healthcare workers, patient preferences, delayed treatment-seeking action, and ambulances prioritising maternal conditions.
Conclusions
Patients’ delay and failure to access prompt and timely referral services result from the healthcare system’s lack of transport, communication problems, bad road networks and shortage of well-trained personnel. Referral delays have deleterious effects on patient-care outcomes.
A non-sense mutation in the Tripartite motif containing 8 (TRIM8 ) gene, mimicking collagenopathy
Authors: Rahman Rehna K , T Harisankar , Mohanlal Smilu , Pachat Divya , Kuruvilla Shalini , Sharma Shephali 
Published: November 2024

Abstract

Tripartite motif-containing 8 (TRIM8) gene mutations are associated with autosomal dominantly inherited neurorenal syndrome. The kidney manifestations range from nephrotic range proteinuria to nephrotic syndrome and kidney failure. The kidney histopathology was focal segmental glomerulosclerosis (FSGS) in all the reported cases. We now report a non-sense mutation in TRIM8 in a 1-year-old boy, mimicking collagenopathy in the kidney biopsy.
What Are the Individual Characteristics or Skills Associated With Baseball Batting Performance? A Scoping Review
Authors: Tremblay Mathieu , Couëpel Bastien , Abboud Jacques , Descarreaux Martin 
Published: November 2024

Abstract

Background
In baseball, batting performance can be measured using game and advanced statistics as well as hitting metrics. To date, the core set of individual characteristics or skills associated to superior batting performance remains to be identified. The aim of this scoping review was to identify and classify the individual characteristics or skills associated with baseball batting performance indicators and describe the methods used to assess these individual characteristics or skills and batting performance indicators.
Methods
A scoping review design was chosen to conduct a systematic literature search. Electronic searches of MEDLINE, SPORTDiscus, and PsycINFO databases were undertaken from inception to August 2024. Cross-sectional studies that investigated the relationship between batting performance indicators and individual characteristics or skills in male or female baseball batters were selected.
Results
Twenty-two cross-sectional studies investigating potential individual characteristics or skills of baseball batting performance met the inclusion criteria. The primary baseball batting performance indicators were grouped into three categories: game statistics, advanced statistics and hitting metrics. Anthropometric measures (height, weight), physical fitness tests (1-RM bench and squat, grip strength, jumps, medicine ball throws, sprint, trunk flexibility, etc.), visual skills (visual acuity, contrast sensitivity, etc.), perceptual skills (anticipation, visual recognition, etc.) and visuomotor skills (eye-hand coordination, reaction time, etc.) were the individual characteristics or skills associated to either game statistics, advanced statistics or hitting metrics.
Conclusions
Based on the studies included in this scoping review, we conclude that greater height, weight, upper-body and lower-body muscle strength, power and speed, oculomotor skills, visual system characteristics, anticipation, and visual recognition as well as visuomotor skills were associated to superior game statistics, advanced statistics or hitting metrics.
Study on Multidimensional Shrinkage Spatial-Temporal Patterns and Driving Forces of Cities in the Yellow River Basin
Authors: Xing Guangrui , Wang Dongfeng , Cai Wanxin 
Published: November 2024

Abstract

With economic globalization and the deepening process of industrialization and urbanization, China's urban development has entered a vital transition stage. As one of the most influential rivers in China, the Yellow River Basin (YRB), with ecological protection and high-quality development as China's national strategy, has not yet received sufficient attention for its urban shrinkage. Accordingly, this study constructs an evaluation index system for the shrinkage of cities in the YRB from four dimensions: population, economy, society and space. The entropy method and analytic hierarchy process are to determine the weights, the shrinkage model, the transfer matrix method and the exploratory spatial data analysis method are used to study the spatial-temporal evolution characteristics of 62 cities with data in the YRB. The multivariate linear (ML) regression method and the random forest (RF) regression method are used comparatively to explore the influences that affect the formation of the cities in the YRB in terms of growth and shrinkage, as well as their influencing roles. The research results show that: (1) urban shrinkage in the YRB is characterized by spatial differentiation and shows a trend of drastic and concentrated development, with the shrinkage phenomenon becoming more and more significant; the degree of population shrinkage, economic shrinkage and social shrinkage is dominated by slight or moderate; the degree of space shrinkage and comprehensive shrinkage is dominated by high and heavy. (2) The reduction in the number of shrinking cities indicates a diminishing urban shrinkage across all dimensions, with a progressively increasing impact.(3) RF regression is more accurate than ML regression. An in-depth exploration of the characteristics of urban shrinkage and its development dynamics in the YRB from a multidimensional perspective will help to narrow the imbalance of urban development, promote high-quality development, and provide an essential reference to promote the progress of urban shrinkage research on a regional scale.
Method for Controlling Setting Time and Determining Pouring Critical Time of Fly Ash Geopolymer
Authors: Sun Qingwei , Zhang Zheming 
Published: November 2024

Abstract

This study identified an effective retarder for fly ash geopolymer by examining the influence of various retarders on its setting time, flow properties, and compressive strength. A novel method for determining the critical pouring time of fly ash geopolymer is proposed. The retarders investigated include zinc nitrate powder, barium chloride, sodium pyrophosphate, glycerol, boric acid, borax, citric acid, and sodium gluconate. Both simple and complex retarding agents were prepared. The effects of different retarders on fly ash geopolymers were analyzed using XRD and SEM tests. When the barium chloride content is less than 2%, BaSiO3 precipitates form in the fly ash geopolymer system. These precipitates intermingle with the gel-like products formed after the cement encounters water, preventing their connection. This delays the setting time and loss of flow capacity.
Based on extensive experimental studies, this paper proposes the "needle insertion resistance method" to determine the critical time for fly ash geopolymer placement, allowing for a more accurate assessment of the placement time range. Considering the combined effects of the alkali amount in the activator and the effective retarder amount, the process of measuring the critical time for fly ash geopolymer pouring using the "needle insertion resistance method" was explored. The applicability of this method was analyzed using XRD and TG/DTG.
The Safety and Efficacy of the Seeking Anatomical Conditions for Creating Tunneling Technique with Precise Resection of Lung Segments at Complex Setting
Authors: Cao Kexin , Zhu Jian , Zheng Jianan , Wei Ke , Li Zhihua , Chen Zhijun , Chen Liang , Wu Weibing 
Published: November 2024

Abstract

Background
Thoracoscopic segmentectomy is the main surgical method for the treatment of early lung cancer. With the promotion of technology and increasingly accurate criteria for lung subsegments, lung nodules with complex positions involving intersegmental and multisegments have become technical bottlenecks. This study aimed to verify whether seeking anatomical conditions for creating tunneling technique with precise resection of lung segments could solve this bottleneck problem.
Methods
The clinical data of patients with lung nodules ≤ 2 cm located in the complex position in the Department of Thoracic Surgery of Jiangsu Provincial People's Hospital from January 2019 to August 2023 were collected. Date analyzed the characteristics of patients who underwent seeking anatomical conditions for creating tunneling technique with precise resection of lung segments (segment group) at complex setting and compared the surgical outcomes and complications between these lobectomy patients (lobectomy group) at similar locations.
Results
A total of 22 patients were included segment group and 47 patients were included lobectomy group. Patients in segment group received a satisfactory surgical margin. Compared to the lobectomy group, surgical outcomes were better (p < 0.05 for postoperative hospital stay and the number of resected subsegments).
Conclusion
Seeking anatomical conditions for creating tunneling technique is a promising technique for performing precise resection of lung segments with a safe resection margin for patients with lung nodules at complex positions involving multiple segments. It can be used as a precise resection of lung segments technique.
Gender-Specific Effects of Virtual Online Physical Education on Fitness Outcomes in Chinese University Students
Authors: Zhang Aowei 
Published: November 2024

Abstract

Background: This study investigates the gender-specific effects of Virtual Online Physical Education (VPE) on fitness outcomes among Chinese university students. With the increasing adoption of AI and virtual technologies in education, understanding how these innovations impact physical fitness is essential.
Results: 18,247 undergraduate students participated in an 8-month VPE intervention. The findings indicated a significant increase in Body Mass Index (BMI) among students (p < 0.05) and a notable decrease in lung capacity (p < 0.01). Male students exhibited a significant improvement in aerobic capacity (p < 0.05), while female students experienced a decline (p < 0.05). Both genders showed substantial gains in flexibility and explosive strength (p < 0.01), although muscular strength (measured by sit-ups for females and pull-ups for males) slightly decreased (p < 0.05). Notably, females showed greater improvements in flexibility and explosive strength, whereas males excelled in aerobic capacity enhancement.
Conclusions: This study underscores the potential of VPE to significantly enhance flexibility and explosive strength in university students, with important implications for gender-specific training approaches. The limitations observed in BMI management and cardiorespiratory function improvement call for tailored training programs that address these disparities, thereby optimizing fitness outcomes for both genders.
Trends in hyperinsulinemia and insulin resistance among nondiabetic US adults, NHANES, 1999-2018
Authors: Wu Chuyue , Ke Yixun , Nianogo Roch 
Published: November 2024

Abstract

Hyperinsulinemia and insulin resistance (IR) are critical predictors of cardiometabolic diseases, disproportionately affecting various sociodemographic groups in the United States. This study aimed to estimate and analyze trends in the prevalence of hyperinsulinemia and IR among nondiabetic adults from 1999 to 2018, using data from the National Health and Nutrition Examination Survey (NHANES). The study included 17,310 nondiabetic men and nonpregnant women aged 20 years or older. Hyperinsulinemia was defined as fasting serum insulin levels ≥10 U/ml, while IR was measured using the HOMA-IR index (≥2.6, 66.7th percentile). The age-standardized prevalence of hyperinsulinemia increased from 28.2% in 1999-2000 to 41.4% in 2017-2018, while IR prevalence rose from 24.8% to 38.4% during the same period. Higher prevalence rates were consistently observed among males, non-Hispanic Blacks, Hispanics, and individuals with lower education or income levels. Trends indicated increases across all sociodemographic groups during at least some time periods. The findings suggest a growing prevalence of hyperinsulinemia and IR in the U.S., particularly among vulnerable populations, underscoring the importance of targeted public health interventions to address these disparities and reduce the risk of cardiometabolic diseases.