bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapists’ and non‐therapists’ constructions of heterosex: A qualitative story completion study
Authors: Shah‐Beckley Iduna , Clarke Victoria , Thomas Zoe 
Published: November 2018

ObjectivesLittle research has examined the discourses that shape therapists’ sense‐making around heterosex. This paper explores the discourses of sexuality and gender underpinning therapists’ and non‐therapists’ responses to a sexual experimentation scenario in a heterosexual relationship. It also considers the value of the novel technique of story completion (SC), in which participants are asked to write a story in response to a hypothetical scenario, for qualitative psychology and psychotherapy research.DesignThis research used a comparative SC design (Kitzinger & Powell, 1995). Participants were sequentially presented with and invited to complete two story stems: one in which a male character suggested ‘trying something new’ to his female partner and one in which the female character made the suggestion. The stems were otherwise identical.MethodsA total of 100 SCs were written by 49 (28 female; 21 male) therapists and 51 (29 female; 22 male) non‐therapists. Participants were recruited mainly via UK‐based email lists and Facebook groups, and therapeutic training organizations, and the data were analysed using a feminist post‐structuralist thematic analysis (Braun & Clarke, 2006).ResultsBoth groups of participants drew on heteronormative discourses of sexuality and gender to make sense of the stem. Engaging in sexual experimentation was often depicted as a demonstration of being normal. In some stories written by women, sex was framed as a site for negotiating ‘equality’ and reciprocity in relationships. Therapists were more likely than non‐therapists to frame ‘difficulties’ within relationships as opportunities for personal growth and increased emotional depth, and their stories included greater emotional complexity.ConclusionThese findings raise questions about practitioner training and whether it results in therapists drawing on narrow and restrictive discourses of heterosex in clinical practice.Practitioner points

Training on sexual issues is largely absent from non‐specialist practitioner training courses, which potentially means therapists are ill‐equipped to respond to clients’ anxiety about sexual issues. Evidence from this and other research indicates that therapists’ sense‐making around heterosexual sexual relationships is underpinned by narrow and restrictive discourses that entrench traditional gender relations and limit sexual agency.

Psychologists are increasingly taking up positions of clinical leadership and are looked to for models of best practice. Drawing on theorizations of sexual difficulties, and of anxieties about sexual practice, that challenge traditional gender and heteronorms, and the commodification and medicalization of sex, is important for effective psychological leadership relating to the treatment of sexual issues and the furthering of social justice agendas.
The lncRNA RMEL3 protects immortalized cells from serum withdrawal‐induced growth arrest and promotes melanoma cell proliferation and tumor growth
Authors: Cardoso Cibele , Serafim Rodolfo B. , Kawakami Akinori , Gonçalves Pereira Cristiano , Roszik Jason , Valente Valeria , Vazquez Vinicius L. , Fisher David E. , Espreafico Enilza M. 
Published: November 2018

AbstractRMEL3 is a recently identified lncRNA associated with BRAFV600E mutation and melanoma cell survival. Here, we demonstrate strong and moderate RMEL3 upregulation in BRAF and NRAS mutant melanoma cells, respectively, compared to melanocytes. High expression is also more frequent in cutaneous than in acral/mucosal melanomas, and analysis of an ICGC melanoma dataset showed that mutations in RMEL3 locus are preponderantly C > T substitutions at dipyrimidine sites including CC > TT, typical of UV signature. RMEL3 mutation does not correlate with RMEL3 levels, but does with poor patient survival, in TCGA melanoma dataset. Accordingly, RMEL3 lncRNA levels were significantly reduced in BRAFV600E melanoma cells upon treatment with BRAF or MEK inhibitors, supporting the notion that BRAF‐MEK‐ERK pathway plays a role to activate RMEL3 gene transcription. RMEL3 overexpression, in immortalized fibroblasts and melanoma cells, increased proliferation and survival under serum starvation, clonogenic ability, and xenografted melanoma tumor growth. Although future studies will be needed to elucidate the mechanistic activities of RMEL3, our data demonstrate that its overexpression bypasses the need of mitogen activation to sustain proliferation/survival of non‐transformed cells and suggest an oncogenic role for RMEL3.
Sequential processing in the classic oddball task: ERP components, probability, and behavior
Authors: Fogarty Jack S. , Barry Robert J. , Steiner Genevieve Z. 
Published: November 2018

AbstractThis study compared the ERP components and behavior associated with the auditory equiprobable and classic oddball tasks, to relate the cognitive processing stages in those paradigms and continue the development of the sequential processing schema. Target and nontarget ERP data were acquired from 66 healthy young adults (Mage = 20.1, SD = 2.4 years, 14 male) who completed both equiprobable (target p = 0.5) and oddball tasks (target p = 0.3). Separate temporal PCAs were used to decompose the ERP data in each task and condition, and the similarity of the components identified in each condition was examined between tasks. Probability effects on component amplitudes and behavior were also analyzed to identify task differences in cognitive demands. A highly similar series of components was identified in each task, closely matching the schema: targets elicited N1‐3, N1‐1, PN, N2c, P3b, SW1, SW2; whereas nontargets elicited N1‐3, N1‐1, PN, N2b, P3a, SW1, SW2. N1‐1 and PN amplitudes increased as stimulus probability decreased, irrespective of the condition. N2b, P3b, SW1, and SW2 amplitudes also varied between tasks, illustrating task‐specific demands on those processing stages. These findings complemented the behavioral outcomes, which demonstrated greater accuracy and control in the classic oddball task. Overall, this study demonstrated comparable processing in the auditory equiprobable and classic oddball tasks, extending the generalizability of the schema and enabling further integration of the ERP theory associated with these tasks. This study also clarifies stimulus probability effects on the schema, providing important insight into the functionality of common ERP components.
Religious polarization, religious conflicts and individual financial satisfaction: Evidence from India
Authors: Migheli Matteo 
Published: November 2018

AbstractThe extant literature finds religion to be a major determinant of life satisfaction. However, in contexts characterized by religious tensions, the outcome may be very different. In particular, the literature shows that religious polarization has a major influence on some economic outcomes. The analysis presented in the paper tries to identify the impact of religious polarization on a major component of life satisfaction: financial satisfaction. The paper inquires how belonging to a minority religion and living in areas with different levels of religious polarization affect the individual satisfaction with the financial situation of the household. The results show that the members of minority religious groups are less satisfied than the members of the dominant group, and that the financial satisfaction decreases—for a given income—as the religious polarization increases.
An Evolutionary Approach to the Study of Collaborative Remembering?
Authors: Amici Federica 
Published: November 2018

AbstractHope and Gabbert (2008) and Jay and colleagues (in press) show us that collaborative remembering, in certain contexts, may result in incomplete and less accurate memories. Here, I will discuss the evolutionary origins of this behavior, linking it to phenomena such as social contagion, conformity, and social learning, which are highly adaptive and widespread across non‐human taxa.
Development and evaluation of a transfusion medicine genome wide genotyping array
Authors: Guo Yuelong , Busch Michael P. , Seielstad Mark , Endres‐Dighe Stacy , Westhoff Connie M. , Keating Brendan , Hoppe Carolyn , Bordbar Aarash , Custer Brian , Butterworth Adam S. , Kanias Tamir , Mast Alan E. , Kleinman Steve , Lu Yontao , Page Grier P. ,   for the National Heart, Lung, and Blood Institute Recipient Epidemiology Donor Evaluation Study (REDS)‐III
Published: November 2018

BACKGROUNDMany aspects of transfusion medicine are affected by genetics. Current single‐nucleotide polymorphism (SNP) arrays are limited in the number of targets that can be interrogated and cannot detect all variation of interest. We designed a transfusion medicine array (TM‐Array) for study of both common and rare transfusion‐relevant variations in genetically diverse donor and recipient populations.STUDY DESIGN AND METHODSThe array was designed by conducting extensive bioinformatics mining and consulting experts to identify genes and genetic variation related to a wide range of transfusion medicine clinical relevant and research‐related topics. Copy number polymorphisms were added in the alpha globin, beta globin, and Rh gene clusters.RESULTSThe final array contains approximately 879,000 SNP and copy number polymorphism markers. Over 99% of SNPs were called reliably. Technical replication showed the array to be robust and reproducible, with an error rate less than 0.03%. The array also had a very low Mendelian error rate (average parent–child trio accuracy of 0.9997). Blood group results were in concordance with serology testing results, and the array accurately identifies rare variants (minor allele frequency of 0.5%). The array achieved high genome‐wide imputation coverage for African‐American (97.5%), Hispanic (96.1%), East Asian (94.6%), and white (96.1%) genomes at a minor allele frequency of 5%.CONCLUSIONSA custom array for transfusion medicine research has been designed and evaluated. It gives wide coverage and accurate identification of rare SNPs in diverse populations. The TM‐Array will be useful for future genetic studies in the diverse fields of transfusion medicine research.
Ex vivo radiocontrast description of the caudal epigastric arteries in horses
Authors: Davis Joseph G. , Ragle Claude A. , Hanna Ashley , DeNome Andrew T. 
Published: November 2018

AbstractObjectiveTo determine the location of the deep and superficial caudal epigastric arteries in relation to 3 midline positions and the relationship between the location of these arteries, body circumference, and body condition score.Study designDescriptive anatomical study.Sample populationNine horses, aged 1‐28 years (mean 10.61 ± 8.89 SD).MethodsBody condition score and body circumference were measured prior to euthanasia. Angiographic studies of the deep and superficial caudal epigastric arteries were performed on resected abdominal walls. The distances between the deep and the superficial caudal epigastric arteries and 3 midline positions were measured. Correlations among these distances, body circumference, and body condition score were analyzed.ResultsThe location of the deep caudal epigastric artery correlated with body circumference and body condition score at the umbilicus (r = 0.53 and 0.68, respectively), midpoint landmark (r = 0.79 and 0.83, respectively), and prepubic tendon attachment (r = 0.69 and 0.78, respectively). The course of this artery could be estimated by multiplying body circumference by 0.04 ± 0.02 at the umbilicus, 0.07 ± 0.01 at the midpoint landmark, and 0.03 ± 0.015 at the prepubic tendon attachment. The course of the superficial caudal epigastric artery did not correlate with anatomic landmarks.ConclusionThe course of the deep caudal epigastric artery could be estimated at 3 midline landmarks on the basis of body circumference and body condition score in equine cadavers.Clinical significancePredicting the course of the caudal epigastric arteries in the equine abdomen based on correlation among location, body circumference, and body condition score may prevent iatrogenic damage during creation of laparoscopic portals.
Effects of intermittent hyperbaric exposure on endurance and interval exercise performance in well‐trained mice
Authors: Suzuki Junichi 
Published: November 2018

New Findings
What is the central question of this study?
Intermittent hyperbaric exposure (1.3 atmospheres absolute with 20.9% O2) enhances endurance capacity by facilitating oxidative and glycolytic capacities in skeletal muscle. It remains unclear whether this strategy enhances endurance performance in well‐trained individuals.

What is the main finding and its importance?
Hyperbaric exposure with endurance training enhanced oxidative and glycolytic capacities and protein levels of mitochondrial transcription factor A, dynamin‐related protein‐1 and heat shock protein 70. Hyperbaric exposure with sprint interval training increased the proportion of type I muscle fibres and promoted capillary growth and muscle fibre hypertrophy. These results may lead to a new strategy for enhancing exercise capacity in well‐trained mice.

AbstractThe study was designed to clarify the mechanisms by which hyperbaric exposure (1.3 atmospheres absolute with 20.9% O2) improves endurance and interval exercise capacities in highly trained mice. Male mice in the training group were housed in a cage with a wheel activity device for 7 weeks from 5 weeks old. Voluntary running markedly increased maximal endurance capacity by 6.4‐fold. Trained mice were then subjected to either endurance treadmill training (20–32.5 m min−1) or sprint interval training (5 s run–10 s rest, 30–42.5 m min−1) with (HypET or HypSIT, respectively) and without (ET or SIT, respectively) 1 h hyperbaric exposure for 4 weeks. Maximal endurance capacity was significantly increased by HypET and HypSIT, and maximal interval capacity was significantly enhanced by HypSIT. Peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha expression levels were markedly increased after HypET and HypSIT. Activity levels of 3‐hydroxyacyl‐CoA‐dehydrogenase, citrate synthase and phosphofructokinase in the red gastrocnemius muscle were increased more by HypET than by ET. Protein levels of mitochondrial transcription factor A, dynamin‐related protein‐1 and heat shock protein 70 were increased more by HypET than by ET. The proportion of type I fibres in the soleus muscle was remarkably increased by HypSIT. Capillary‐to‐fibre ratio values in the white gastrocnemius were increased more by HypSIT than by SIT. These results suggest that hyperbaric exposure has beneficial effects for endurance and interval training to improve exercise capacity in highly trained mice.
Electronic exchange-correlation, many-body effect issues on first-principles calculations of bulk SiC polytypes
Authors: Demmouche Kamel , Coutinho José 
Published: November 2018

The first-principles Projector-Augmented Wave method (PAW) is used to investigate the electronic, phonon band structure and dielectric properties of four bulk silicon carbide (SiC) polytypes. We employ PAW pseudopotential density functional theory with Perdew, Burke and Ernzerhof (PBE) and hybrid HSE06 approximations of the exchange-correlation functional. Many-body effects are incorporated using the GW approximation of the self-interaction to study SiC properties. GW method in its single-shot variant, which is based on the many-body perturbation theory (MBPT), is used to calculate the quasi-particle (QP) energies of the band structure and the dielectric properties for different polytypes. The electronic band structure determination within GW method uses the Wannier procedure where a basis set of maximally localized Wannier function (MLWF) is constructed to interpolate the QP energies of few regular mesh k-points to the high-symmetry lines in Brillouin zone. As a consequence of QP correction to the Kohn–Sham energies, bandgap is increased by upto 3 eV in case of 4H–SiC, as compared to PBE bandgap. GW results are comparable to those of hybrid functionals and are in good agreement with the experimental results. The optical properties are then studied within PBE, HSE06 and include many-body effects. In addition, the phonon band structure has been investigated within HSE06 and compared to previous PBE results. We found good agreement with the previous theoretical results and the experimental available data.
ЗМІНИ БІОХІМІЧНИХ ПОКАЗНИКІВ І ФУНКЦІОНАЛЬНОЇ АКТИВНОСТІ СЕРЦЯ ВИСОКО- І НИЗЬКОСТІЙКИХ ДО ГОСТРОЇ ГІПОКСИЧНОЇ ГІПОКСІЇ ЩУРІВ РІЗНОЇ СТАТІ ПРИ ІММОБІЛІЗАЦІЙНОМУ СТРЕСІ
Authors: Ordynskyi Iu. M. , Denefil O. V. 
Published: November 2018

Вступ. Визначення механізмів ушкоджувального впливу стресу на серце в осіб з різною реактивністю може сприяти розробці індивідуальних методів корекції.
Метадослідження – визначити вплив іммобілізаційного стресу на зміни пероксидного окиснення ліпідів, антиоксидантного захисту та показники електрокардіограм у щурів різної статі з високою і низькою стійкістю до гіпоксії (ВГ та НГ).
Методи дослідження. Стрес моделювали 4 рази шляхом одногодинної іммобілізації щурів спинкою донизу з інтервалом 24 год. У серці визначали концентрацію дієнових і трієнових кон’югатів, шиффових основ, ТБК-активних продуктів, активність супероксиддисмутази, каталази. Реєстрували електрокардіограми.
Результати й обговорення. У контрольних ВГ самців, порівняно з НГ, виявлено нижчу активність процесів пероксидного окиснення ліпідів, вищу активність супероксиддисмутази, у ВГ самиць порівняно з НГ – більше продуктів пероксидного окиснення ліпідів, супероксиддисмутази, меншу активність каталази. Іммобілізація призвела до розвитку окиснювального і карбонільного стресу, більше в самців порівняно із самицями. При дослідженні електрокардіограм тільки за умов стресу у ВГ самиць збільшились амплітуда зубця R, відхилення SТ відносно ізолінії, у НГ зросла частота серцевих скорочень, зменшилася тривалість інтервалів RR і QTc.
Висновки. Інтервальна іммобілізація щурів призводить до окиснювального та карбонільного стресу в серці, але механізми його розвитку залежать від стійкості до гіпоксії і статі. При іммобілізаційному стресі зміни на електрокардіограмах відмічено тільки в самиць.
ОСОБЛИВОСТІ ОКСИДАТИВНИХ ПРОЦЕСІВ ПРИ ЕКСПЕРИМЕНТАЛЬНІЙ МЕХАНІЧНІЙ НЕПРОНИКНІЙ ТРАВМІ РОГІВКИ
Authors: Nesteruk S. V. , Klishch I. M. 
Published: November 2018

Вступ. Дезорганізація процесів пероксидного окиснення має важливе значення в патогенезі механічної непроникної травми рогівки, однак ці взаємозв’язки вивчено недостатньо, що спонукало нас провести дослідження власне такого напрямку.
Мета дослідження – вивчити зміни інтенсивності пероксидного окиснення ліпідів, білків та вміст метаболітів нітрогену монооксиду в крові кролів за умов механічної непроникної травми рогівки в ди­наміці.
Методи дослідження.Експериментальні дослідження проводили на статевозрілих кролях породи “Шиншила”. Для вивчення особливостей вільнорадикального окиснення при експериментальній механічній непроникній травмі ока спектрофотометрично в крові визначали концентрацію гідропероксидів, вміст ТБК-реактантів, ступінь окиснювальної модифікації білків, рівень метаболітів нітрогену монооксиду.
Результати й обговорення. Встановлено підвищення вмісту продуктів білкової і ліпідної пероксидації в крові кролів за умови механічної непроникної травми рогівки. Результати нашого дослідження свідчать про хвилеподібну динаміку змін кінцевих продуктів нітрогену монооксиду в сироватці крові тварин при механічній непроникній травмі рогівки.
Висновки. За умови експериментальної непроникної травми рогівки спостерігають достовірне зростання у крові показників пероксидного окиснення ліпідів (підвищення рівнів гідропероксидів і ТБК‑активних продуктів) та окиснювальної модифікації білків (альдегідо- і кетонопохідних динітро­фенілгідразонів нейтрального й основного характеру) стосовно контролю з мінімальними значеннями на 7 добу та максимальними – на 14 добу (р<0,05). Експериментальна непроникна травма рогівки супроводжується зниженням рівня кінцевих продуктів нітрогену монооксиду на 3–7 доби в середньому на 26,0 % з наступним зростанням на 10 і 14 доби, відповідно, на 8,0 та 24,9 % відносно контрольної групи (p<0,01).
КОАГУЛЯЦІЙНИЙ ПОТЕНЦІАЛ КРОВІ У ХВОРИХ НА ХРОНІЧНЕ ОБСТРУКТИВНЕ ЗАХВОРЮВАННЯ ЛЕГЕНЬ ПРОФЕСІЙНОЇ ЕТІОЛОГІЇ РІЗНОГО СТУПЕНЯ ТЯЖКОСТІ
Authors: Ivchuk V. V. , Kopteva T. Yu. , Kovalchuk T. A. 
Published: November 2018

Вступ. Важливе місце серед захворювань дихальної системи займає хронічне обструктивне захворювання легень (ХОЗЛ) професійної етіології, яке супроводжується змінами не лише в респіраторному тракті, але і в системі гемостазу.
Мета дослідження – оцінити систему згортання крові за перебігу ХОЗЛ професійної етіології різного ступеня тяжкості.
Методи дослідження. Проаналізовано результати досліджень капілярної та венозної крові 112 працівників гірничодобувної промисловості, хворих на ХОЗЛ різного ступеня тяжкості. Серед пацієнтів 34 особи мали І стадію захворювання, 40 осіб – ІІ стадію, 38 осіб – ІІІ стадію, 29 практично здорових осіб становили контрольну групу. Стан системи гемостазу оцінювали за такими параметрами, як: кількість тромбоцитів, концентрація фібриногену, рівні активованого часткового тромбопластинового часу, тромбінового часу, міжнародного нормалізованого відношення, протромбінового індексу, протромбінового відношення.
Результати й обговорення. Аналіз показників протромбінового профілю показав, що у хворих на ХОЗЛ ІІ–ІІІ стадій переважно змінювались рівні факторів коагуляційного каскаду, що свідчило про порушення у зовнішній ланці системи згортання крові. У міру збільшення тяжкості перебігу ХОЗЛ професійної етіології зміни рівнів факторів коагуляційного каскаду вказували на порушення системи гемостазу в бік гіперкоагуляції та депресії фібринолітичного потенціалу крові.
Висновки. За перебігу ХОЗЛ професійної етіології відбуваються порушення в коагуляційній ланці гемостазу в бік гіперкоагуляції разом зі збільшенням тяжкості захворювання. Порушення в згортувальній ланці гемостазу у хворих на ХОЗЛ професійної етіології відзначають в основному по зовнішньому шляху згортання крові.
In‐office versus Operating Room Sialendoscopy: Comparison of Outcomes, Patient Time Burden, and Charge Analysis
Authors: Coniglio Andrew J. , Deal Allison M. , Bhate Oam , Hackman Trevor G. 
Published: November 2018

ObjectiveTo evaluate outcomes of in‐office versus operating room (OR) sialendoscopy/sialolithotomy and to recognize the efficiency of outpatient salivary gland surgery with significant time and facility charge reductions.Study DesignCase series with chart review.SettingState hospital OR and ambulatory clinic.Subjects and MethodsRetrospective review was performed of adult patients treated for inflammatory salivary diseases by a single surgeon from 2011 to 2016. The patients were divided into 2 groups based on procedure setting (office vs OR) and compared by various baseline features, including demographics, symptom onset and duration, stone size, symptomatic improvement, and recurrence. Patient time burden was compared via office procedure records and OR time charting from the electronic health record. Retrospective clinic and hospital charge sheets were tallied and similarly compared.ResultsThe 2 cohorts (office, n = 111; OR, n = 96) were comparable in all demographics, including sialolith number and size (7.36 vs 6.69 mm, P =. 45). Additional subgrouping was statistically similar. Both cohorts had similar postprocedure symptom improvement (97% vs 95.8%, P =. 65) and recurrence rates (8.9% vs 14.5%, P =. 22) independent of subgroup. Overall time burden for patients was 39 minutes in the office versus 277 minutes in the OR (P ≤. 0001). Procedure and hospital charge data were tallied and compared (office, $719.21; OR, $13,956.14; P ≤. 0001).ConclusionBothcohorts were statistically similar in all features. There was significant reduction in patient time burden and health care charges with office‐based procedures while maintaining similar symptom improvement and recurrence rates.