bluuebunny/crossref_metadata_2025_split huggingface dataset:
<b>Análise das etapas do processo de cuidado ao paciente com cateter central/ Analysis of the care process steps in patient with central catheter<b>
Authors: Silva Juciana Isabel da , Leal Sandra Maria Cezar , Bittencourt Betina , Viegas Karin 
Published: March 2019

Objetivo: analisar as Etapas do Processo de Cuidado ao Paciente com Cateter Venoso Central (CPCVC) buscando identificar falhas potenciais para a prevenção de infecção de corrente sanguínea na unidade de terapia intensiva. Método: utilizou-se o Método de Análise de Falhas e Efeitos. Estudo realizado nas Unidades de Terapia Intensiva de um hospital de grande porte na cidade de Caxias do Sul. Nove profissionais de enfermagem constituíram o grupo de avaliação. Para o cálculo de risco, foram definidas a gravidade, a probabilidade de ocorrência e a possibilidade de detecção em cada item avaliado. Resultados: os resultados apontaram inconformidades como falta de critério de indicação e riscos relacionados à proteção de barreira e à inserção e manutenção do cateter. Conclusão: considera-se que a equipe estava comprometida com a qualificação do processo de CPCVC. Entretanto, é necessária a implementação de estratégias para promover ações que impeçam a ocorrência das falhas potenciais.
<b> Eletrocauterização de verrugas venéreas: presença de bioaerossóis na fumaça cirúrgica/Eletrocauterization of venerealwarts: presence of bioaerosols in surgical smoke
Authors: Oussaki Luana Cristine dos Santos , Ribeiro Renata Perfeito , Pinhatti Evelin Daiane Gabriel , Pissinati Paloma De Souza Cavalcante , Martins Júlia Trevisan 
Published: March 2019

Objetivo: analisar a capacidade dos filtros de retenção de bioaerossóis com o uso de aspirador de fumaça cirúrgica em procedimentos de cauterização de verrugas venéreas. Método: pesquisa de campo, descritiva, transversal e quantitativa. O estudo foi desenvolvido em um centro de referência para infecções sexualmente transmissíveis no Norte do estado do Paraná, no ambulatório de urologia. A coleta de dados foi realizada no período de abril a julho de 2016, com uma amostra obtida a partir de 72 procedimentos de cauterização. Realizou-se análise estatística descritiva. Resultados: foram analisados 24 filtros acoplados em dois equipamentos, utilizados para aspiração da fumaça. O método da Reação em Cadeia da Polimerase convencional foi utilizado para a leitura dos filtros, sendo utilizados primers específicos para a pesquisa de Herpes Simples, Herpes Zoster, Hepatite C, Vírus da Imunodeficiência Humana, Hepatite B e Papiloma Vírus Humano. A partir das amostras analisadas foram encontrados Ácido Desoxirribonucleico viral do Herpes Simples, Hepatite B e Papiloma Vírus Humano nos filtros analisados. Conclusão: O uso de um equipamento de aspiração de fumaça cirúrgica, com filtros Ultra-low Particulate Air , durante as cauterizações de verrugas venéreas mostrou-se capaz de reter bioaerossóis quando respeitado o tempo de troca dos filtros.
Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality
Authors: Thangavelu Govindarajan , Lee Yu-Chi , Loschi Michael , Schaechter K. Melanie , Feser Colby J. , Koehn Brent H. , Nowak Elizabeth C. , Zeiser Robert , Serody Jonathan S. , Murphy William J. , Munn David H. , Chambon Pierre , Noelle Randolph J. , Blazar Bruce R. 
Published: March 2019

Abstract
Recent studies have underscored the critical role of retinoic acid (RA) in the development of lineage-committed CD4 and CD8 T cells in vivo. We have shown that under acute graft-versus-host disease (GVHD) inflammatory conditions, RA is upregulated in the intestine and is proinflammatory, as GVHD lethality was attenuated when donor allogeneic T cells selectively expressed a dominant negative RA receptor α that blunted RA signaling. RA can function in an autocrine and paracrine fashion, and as such, the host cell lineage responsible for the production of RA metabolism and the specific RA-metabolizing enzymes that potentiate GVHD severity are unknown. In this study, we demonstrate that enhancing RA degradation in the host and to a lesser extent donor hematopoietic cells by overexpressing the RA-catabolizing enzyme CYP26A1 reduced GVHD. RA production is facilitated by retinaldehyde isoform-2 (RALDH2) preferentially expressed in dendritic cells (DCs). Conditionally deleted RA-synthesizing enzyme RALDH2 in host or to a lesser extent donor DCs reduced GVHD lethality. Improved survival in recipients with RALDH2-deleted DCs was associated with increased T cell death, impaired T effector function, increased regulatory T cell frequency, and augmented coinhibitory molecule expression on donor CD4+ T cells. In contrast, retinaldehydrogenase isoform-1 (RALDH1) is dominantly expressed in intestinal epithelial cells. Unexpectedly, conditional host intestinal epithelial cells RALDH1 deletion failed to reduce GVHD. These data demonstrate the critical role of both donor and especially host RALDH2+ DCs in driving murine GVHD and suggest RALDH2 inhibition or CYP26A1 induction as novel therapeutic strategies to prevent GVHD.
Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4–MyD88 Complex
Authors: Zaro Balyn W. , Vinogradova Ekaterina V. , Lazar Daniel C. , Blewett Megan M. , Suciu Radu M. , Takaya Junichiro , Studer Sean , de la Torre Juan Carlos , Casanova Jean-Laurent , Cravatt Benjamin F. , Teijaro John R. 
Published: March 2019

Abstract
Dimethyl fumarate (DMF) is a prescribed treatment for multiple sclerosis and has also been used to treat psoriasis. The electrophilicity of DMF suggests that its immunosuppressive activity is related to the covalent modification of cysteine residues in the human proteome. Nonetheless, our understanding of the proteins modified by DMF in human immune cells and the functional consequences of these reactions remains incomplete. In this study, we report that DMF inhibits human plasmacytoid dendritic cell function through a mechanism of action that is independent of the major electrophile sensor NRF2. Using chemical proteomics, we instead identify cysteine 13 of the innate immune kinase IRAK4 as a principal cellular target of DMF. We show that DMF blocks IRAK4–MyD88 interactions and IRAK4-mediated cytokine production in a cysteine 13–dependent manner. Our studies thus identify a proteomic hotspot for DMF action that constitutes a druggable protein–protein interface crucial for initiating innate immune responses.
La guerre en Syrie dans la presse en ligne : quelle expressivité dans les commentaires publics?
Authors: Lazar Jan 
Published: March 2019

La guerre se définit comme une situation conflictuelle entre deux ou plusieurs pays, états, groupes sociaux, individus, avec ou sans lutte armée. Actuellement, la guerre en Syrie préoccupe les médias occidentaux, y compris la presse en ligne. La guerre civile syrienne a éclaté dans le contexte du Printemps arabe par des manifestations majoritairement pacifiques en faveur de la démocratie contre le régime baasiste dirigé par le président Bachar el-Assad. Elle sʼest rapidement transformée en rébellion armée qui a exigé lʼengagement de certains pays occidentaux, ce qui a provoqué de nombreuses discussions. Dans cette communication nous tentons de comprendre comment le phénomène de la guerre peut intervenir dans les choix de dévoilements identitaires des internautes. Il convient de préciser que le choix du pseudonyme est l’un des premiers actes de création individuelle de l’internaute : avant de s’exprimer par la langue, il va devoir se nommer. Lʼobjectif de notre article est dʼanalyser plus en détail quel est le lien entre l´expressivité des commentaires et lʼidentité numérique. Nous voulons aussi examiner si la possibilité de masquer lʼidentité est un facteur déclencheur de lʼusage des mots argotiques. Pour répondre à ces questions nous proposons une étude comparative de deux corpus de commentaires publics apparaissant sur des sites de presse en ligne qui décrivent la guerre en Syrie. Le premier corpus sera constitué sur la base de sites tchèques (Idnes.cz, Blesk.cz), le second sur la base de sites français (20.minutes.fr, Closer.fr), selon un protocole identique.
La construction du discours anti-djihadiste sur Internet : enjeux, thématiques, procédés
Authors: Konowska Agnieszka 
Published: March 2019

Cet article analyse certains aspects particuliers de la construction du discours anti-djihadiste d’internautes européens qui semblent avoir déclaré une guerre ouverte aux terroristes islamistes. Se déroulant sur le plan discursif, cette guerre se manifeste sous forme de phénomènes communicationnels divers. Il s’agit ici d’analyser un type de messages spécial, exploitant différents codes sémiotiques (surtout iconique et verbal) qui, de par leur caractère humoristique attrayant, captent l’attention du public et acquièrent une grande popularité en peu de temps : les mèmes numériques et les dessins satiriques. Largement relayés sur Internet, ces phénomènes viraux prennent appui sur l’humour. Et puisque tout acte de discours humoristique est un acte d’énonciation à des fins stratégiques pour faire de son interlocuteur un complice, ces messages sont d’excellents outils de lutte discursive contre la propagande et les actes djihadistes. Ils sont susceptibles de produire sur l’auditoire un effet de connivence qui entraîne l’adhésion du destinataire à la disqualification de la cible du discours. L’article décrit la façon dont s’effectue cette disqualification de l’image du djihad et de l’islam en général, ainsi que le matériel verbal et iconique exploités à cette fin. On s’intéressera aux principes et aux procédés de construction du discours en question, à ses effets humoristiques dans le contexte de son apparition, de même qu’à sa finalité et sa thématique.
Le Poilu en traduction roumaine. Étude de cas : Le Feu d’Henri Barbusse
Authors: Bălă Laurențiu 
Published: March 2019

Quatre ans après qu’on a fêté le centenaire du commencement de la Première Guerre mondiale, en 2014, notre contribution se veut un modeste hommage aux braves soldats français (les « poilus ») qui ont perdu leur vie dans une conflagration ayant duré quatre ans. Le corpus de notre étude sera constitué par les deux versions roumaines d’un même roman, Le Feu, dont l’auteur, Henri Barbusse a pris part en tant que combattant en première ligne à ce conflit sanglant, décrivant les horreurs de la guerre avec indignation et douceur, mais non sans humour. Paru en 1916 et remportant le prestigieux Prix Goncourt la même année, Le Feu (Journal d’une escouade) a connu sa première version roumaine en 1918, la seconde étant publiée 37 ans plus tard, en 1955. Notre but sera de voir comment les deux traducteurs ont réussi à rendre en roumain l’argot spécial des soldats français (appelé « poilu » d’après leur propre surnom, mot qui signifie dans l’argot français « brave, courageux »), et cela dans des périodes où ce phénomène linguistique n’était pas très connu en Roumanie (l’entre-deux-guerres) ou bien on ne lui reconnaissait presque même pas l’existence (après l’installation du communisme, survenue en 1947) !
A study of the dynamical characteristics of inertia–gravity waves in the Antarctic mesosphere combining the PANSY radar and a non-hydrostatic general circulation model
Authors: Shibuya Ryosuke , Sato Kaoru 
Published: March 2019

Abstract. This study aims to examine the dynamical characteristics of gravity waves
with relatively low frequency in the Antarctic mesosphere via the first
long-term simulation using a high-top high-resolution non-hydrostatic general
circulation model (NICAM). Successive runs lasting 7 days are performed using
initial conditions from the MERRA reanalysis data with an overlap of 2 days
between consecutive runs in the period from April to August in 2016. The data
for the analyses were compiled from the last 5 days of each run. The
simulated wind fields were closely compared to the MERRA reanalysis data and
to the observational data collected by a complete PANSY (Program of the
Antarctic Syowa MST/IS radar) radar system installed at Syowa Station
(39.6∘ E, 69.0∘ S). It is shown that the NICAM mesospheric
wind fields are realistic, even though the amplitudes of the wind
disturbances appear to be larger than those from the radar observations. The power spectrum of the meridional wind fluctuations at a height of 70 km
has an isolated and broad peak at frequencies slightly lower than the
inertial frequency, f, for latitudes from 30 to 75∘ S, while another isolated peak is observed at frequencies of approximately
2π∕8 h at latitudes from 78 to 90∘ S. The
spectrum of the vertical fluxes of the zonal momentum also has an isolated
peak at frequencies slightly lower than f at latitudes from 30 to 75∘ S at a height of 70 km. It is shown that these isolated
peaks are primarily composed of gravity waves with horizontal wavelengths of
more than 1000 km. The latitude–height structure of the momentum fluxes
indicates that the isolated peaks at frequencies slightly lower than f
originate from two branches of gravity wave propagation paths. It is thought
that one branch originates from 75∘ S due to topographic gravity
waves generated over the Antarctic Peninsula and its coast, while more than
80 % of the other branch originates from 45∘ S and includes
contributions by non-orographic gravity waves. The existence of isolated
peaks in the high-latitude region in the mesosphere is likely explained by
the poleward propagation of quasi-inertia–gravity waves and by the
accumulation of wave energies near the inertial frequency at each latitude.
Serving and love – Values in ethical nursing leadership
Authors: Honkavuo Leena 
Published: March 2019

Background: The significance of ethical and serving nursing leadership is the greatest contributing factors to attain good and quality assured care for patients. Prioritizing an ethical attitude and value base within the different levels of healthcare organizations opens up for well-being among patients, nurses, and nurse leaders. Polarization and many restructurings have changed the value base of healthcare organizations and the nursing culture so that serving and ethical values have been deprioritised rather than reinforced. Objective: To deepen the understanding of serving and ethical nursing leadership and to examine how nurse leaders through their ethos can pave the way toward the evident – the good, the truthful and the beautiful serving in the context of nursing administrations.Methodology: Qualitative, descriptive and hermeneutic approach with inductive elements. The material consists of deep interviews with six nurse leaders. The hermeneutic reading act and interpretation of the interview texts are inspired by Hans-Georg Gadamer’s philosophical thought.Result: Ethical leadership that serves the guest of honour of the healthcare organization, the patient, and the caring culture are made visible in the context of nursing administration through “The good, the truthful and the beautiful” timeless movement directed toward health, healing and the meaning of life. Ethos gives to nursing leadership a value base and fundamental attitude, and is linked to the responsibility of nursing administrations, dignity and holiness.Implications for nursing management: Ethical and serving nurse leaders are attractive and legitimate role models for today’s nursing administrations. Nurse leaders’ direct influence, ethos and serving are factors that are closely connected with the ethical climate of the healthcare organization.
Impact assessment of pharmacovigilance-related educational intervention on nursing students’ knowledge, attitude and practice: A pre-post study
Authors: Palaian Subish , Ibrahim Mohamed Izham Mohamed , Mishra Pranaya , Shankar Pathiyil Ravi 
Published: March 2019

Objective: This study evaluated the impact of a pharmacovigilance education module for nursing students.Methods: In this prospective, pre-post interventional study, the 2nd year diploma in Nursing students (n = 38) were the ‘test’ group (who received intervention), and the 1st and 3rd year students were the control group (n = 78); total n = 116. Knowledge Attitude Practice (KAP) responses were taken at baseline (0 day), 30 days, 90 days and 180 days from both the groups. Improvements in the KAP scores following the intervention was analyzed using Wilcoxon signed rank test at alpha = .05, and the feedback was obtained using a ‘Likert scale’ having 20 questions; maximum possible score was 100.Results: The median (IQR) overall baseline scores of knowledge were 11 (10-12), the attitude/practice scores were 22 (20.25-22.00) and the total scores was 32.5 (31-34); the maximum possible score was 40. Almost all (n = 113; 97.4%) of them felt adverse drug reactions reporting was necessary and were interested in learning about adverse drug reactions. The baseline KAP scores were significantly higher among the second- and third-year students compared to the first year (p < .001). Upon intervention, a significant improvement was seen in knowledge scores between the baseline and first follow-up (p = .018) and between second and third follow-up (p = .001) in the test group. The median (IQR) feedback score was 85 (80.7-88.2).Conclusions: Students had better attitude/practice scores, but a poor knowledge score at baseline. This study confirmed the feasibility of conducting a pharmacovigilance module for nursing students in Nepal.
Acessibilidade nas escolas como uma questão de direitos humanos
Authors: Silva Filho Daniel Mendes da , Magalhães Kassar Mônica de Carvalho 
Published: March 2019

A presença de alunos com deficiências e com dificuldades de locomoção nas escolas tem impulsionado diversas mudanças, dentre elas, as relativas à organização dos espaços. Este artigo tem como objetivo analisar a acessibilidade arquitetônica em escolas públicas, sob a perspectiva do cumprimento de diretos fundamentais, como o reconhecimento como pessoa, o recebimento de instrução/educação, a liberdade de locomoção e a segurança pessoal, entre outros. Para o desenvolvimento deste estudo, inicialmente, realizou-se um levantamento documental, que levou ao conhecimento do delineamento do discurso político sobre a acessibilidade, nos planos nacional e internacional. Posteriormente, foram coletados dados estatísticos públicos, disponibilizados pelo Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP), referentes às condições de acessibilidade nas escolas que compõem a rede pública de ensino de um município polo para as políticas de educação inclusiva, no estado de Mato Grosso do Sul. Por último, foram realizadas visitas em escolas urbanas de Ensino Fundamental do município que receberam adequações arquitetônicas visando à acessibilidade. Esses espaços foram registrados com uma câmera fotográfica para posterior análise. Foram abordados aspectos relativos aos avanços sobre a constituição dos direitos das pessoas com deficiências, com a atenção voltada à materialização das condições de acessibilidade arquitetônica nas instituições escolares como uma forma de leitura do respeito a essas pessoas na sociedade atual. Os resultados indicam que a rede municipal tem se organizado para cumprir as metas dos programas do governo federal no tocante à acessibilidade arquitetônica na escola. Porém, as alterações realizadas não garantem os fins propostos.
Estimation of Geothermal Gradient and Heat Flow for Determination of Geothermal Energy Sources in Monguno Area of Northeastern Nigeria
Authors: Udochukwu B. C. , Akiishi M. , Tyovenda A. A. 
Published: March 2019

The aeromagnetic data of Monguno area northeastern Nigeria have been used to estimate Curie point depth, geothermal gradients and heat flow using spectral analysis. These geothermal parameters were subsequently employed to identify areas of geothermal resources. First order polynomial fitting was applied in Regional-residual separation. The Curie point depth obtained in this area ranges from 10.318 to 24.476 km with an average of 13.387 km, the geothermal gradient of the area varies from 23.697 to 56.212°C /km, with an average of 46.195°C /km, while the heat flow ranges from 59.242 to 136.176 mWm-2, with an average value of about 112.364 mWm-2. It was also observed that the deepest Curie depth in the area is identified in the south, while the shallow depth is located in the northeast and spread toward the southwest. On the other hand, the highest geothermal gradient in the area is identified in the northern part of Moguno, while in the south, the lowest, geothermal gradient is located. The highest heat flow in the area is seen in the south-west and north-east, while the lowest heat flow is observed in the south. The high heat flow and geothermal gradient in the area show that geothermal energy could be found in Monguno region of the northeastern Nigeria.
A Facile One‐Step Approach for Constructing Multidimensional Ordered Nanowire Micropatterns via Fibrous Elastocapillary Coalescence
Authors: Bian Ruixin , Meng Lili , Guo Cheng , Tang Zhongxue , Liu Huan 
Published: March 2019

AbstractNanowire (NW) based micropatterns have attracted research interests for their applications in electric microdevices. Particularly, aligning NWs represents an important process due to the as‐generated integrated physicochemical advantages. Here, a facile and general strategy is developed to align NWs using fibrous elastocapillary coalescence of carbon nanotube arrays (ACNTs), which enables constructing multidimensional ordered NW micropatterns in one step without any external energy input. It is proposed that the liquid film of NW solution is capable of shrinking unidirectionally on the top of ACNTs, driven by the dewetting‐induced elastocapillary coalescence of the ACNTs. Consequently, the randomly distributed NWs individually rotate and move into dense alignment. Meanwhile, the aggregating and bundling of ACNTs is helpful to produce carbon nanotube (CNT) yarns connecting neighboring bundles. Thus, a micropatterned NW network composed of a top‐layer of horizontally aligned NWs and an under‐layer of vertical ACNT bundles connected by CNT yarns is prepared, showing excellent performance in sensing external pressure with a sensitivity of 0.32 kPa−1. Moreover, the aligned NWs can be transferred onto various substrates for constructing electronic circuits. The strategy is applicable for aligning various NWs of Ag, ZnO, Al2O3, and even living microbes. The result may offer new inspiration for fabricating NW‐based functional micropatterns.
Catalytic Enantioselective Aldol‐Type Reaction Using α‐Fluorinated Enolates
Authors: Gong Yi , Yu Jin‐Sheng , Hao Yong‐Jia , Zhou Ying , Zhou Jian 
Published: March 2019

AbstractOptically active α‐fluoroalkyl substituted alcohols are widely present in drugs and pharmaceutically active compounds. Catalytic enantioselective aldol‐type reaction using fluorinated enolates constitutes a powerful method for the synthesis of α‐fluorinated β‐hydroxy carbonyl compounds, which are versatile building blocks to access α‐fluorinated alcohols bearing different functionalities through an array of transformations based on carbonyl group. This Focus Review summarizes recent achievements of the catalytic enantioselective aldol reactions using fluorinated enolates derived from five different types of precursors, discusses in detail the limitation of each method, and outlines synthetic opportunities still present.