bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precision Medicine for Relapsed Multiple Myeloma on the Basis of an Integrative Multiomics Approach
Authors: Laganà Alessandro , Beno Itai , Melnekoff David , Leshchenko Violetta , Madduri Deepu , Ramdas Dennis , Sanchez Larysa , Niglio Scot , Perumal Deepak , Kidd Brian A. , Miotto Riccardo , Houldsworth Jane , Shaknovich Rita , Chari Ajai , Cho Hearn Jay , Barlogie Bart , Jagannath Sundar , Dudley Joel T. , Parekh Samir 
Published: August 2018

Purpose Multiple myeloma (MM) is a malignancy of plasma cells, with a median survival of 6 years. Despite recent therapeutic advancements, relapse remains mostly inevitable, and the disease is fatal in the majority of patients. A major challenge in the treatment of patients with relapsed MM is the timely identification of treatment options in a personalized manner. Current approaches in precision oncology aim at matching specific DNA mutations to drugs, but incorporation of genome-wide RNA profiles has not yet been clinically assessed. Methods We have developed a novel computational platform for precision medicine of relapsed and/or refractory MM on the basis of DNA and RNA sequencing. Our approach expands on the traditional DNA-based approaches by integrating somatic mutations and copy number alterations with RNA-based drug repurposing and pathway analysis. We tested our approach in a pilot precision medicine clinical trial with 64 patients with relapsed and/or refractory MM. Results We generated treatment recommendations in 63 of 64 patients. Twenty-six patients had treatment implemented, and 21 were assessable. Of these, 11 received a drug that was based on RNA findings, eight received a drug that was based on DNA, and two received a drug that was based on both RNA and DNA. Sixteen of the 21 evaluable patients had a clinical response (ie, reduction of disease marker ≥ 25%), giving a clinical benefit rate of 76% and an overall response rate of 66%, with five patients having ongoing responses at the end of the trial. The median duration of response was 131 days. Conclusion Our results show that a comprehensive sequencing approach can identify viable options in patients with relapsed and/or refractory myeloma, and they represent proof of principle of how RNA sequencing can contribute beyond DNA mutation analysis to the development of a reliable drug recommendation tool.
Normobaric Hypoxia Reduces V˙O2 at Different Intensities in Highly Trained Runners
Authors: SHARMA AVISH P. , SAUNDERS PHILO U. , GARVICAN-LEWIS LAURA A. , CLARK BRAD , GORE CHRISTOPHER J. , THOMPSON KEVIN G. , PÉRIARD JULIEN D. 
Published: August 2018

ABSTRACT

Introduction
We sought to determine the effect of low and moderate normobaric hypoxia on oxygen consumption and anaerobic contribution during interval running at different exercise intensities.

Methods
Eight runners (age, 25 ± 7 yr, V˙O2max: 72.1 ± 5.6 mL·kg−1·min−1) completed three separate interval sessions at threshold (4 × 5 min, 2-min recovery), V˙O2max (8 × 90 s, 90-s recovery), and race pace (10 × 45 s, 1 min 45 s recovery) in each of; normoxia (elevation: 580 m, FiO2: 0.21), low (1400 m, 0.195) or moderate (2100 m, 0.18) normobaric hypoxia. The absolute running speed for each intensity was kept the same at each altitude to evaluate the effect of FiO2 on physiological responses. Expired gas was collected throughout each session, with total V˙O2 and accumulated oxygen deficit calculated. Data were compared using repeated-measures ANOVA.

Results
There were significant differences between training sessions for peak and total V˙O2, and anaerobic contribution (P < 0.001, P = 0.01 respectively), with race pace sessions eliciting the lowest and highest responses respectively. Compared to 580 m, total V˙O2 at 2100 m was significantly lower (P < 0.05), and anaerobic contribution significantly higher (P < 0.05) during both threshold and V˙O2max sessions. No significant differences were observed between altitudes for race pace sessions.

Conclusions
To maintain oxygen flux, completing acute exercise at threshold and V˙O2max intensity at 1400 m simulated altitude appears more beneficial compared with 2100 m. However, remaining at moderate altitude is a suitable when increasing the anaerobic contribution to exercise is a targeted response to training.
Continence care education: views of students and registered nurses
Authors: Ferdinand Sarah 
Published: August 2018

Background: this article reports on a study of continence education and training for students and qualified nurses. Aims: to understand how nurses and nursing students gain their knowledge in continence education and training, to examine nurses' understanding of bladder and bowel care and to discover to what degree nurses are confident in their knowledge of bladder and bowel care. Methods: this was a qualitative enquiry and a case study methodology was used to frame the research. The data were captured through a questionnaire and group discussions. Findings: continence education comprised support through self-learning, classroom instruction, skills laboratory sessions and on the wards. Feedback from participants indicated that, although continence education enhanced learning, they thought continence education sessions were either too short or did not go into enough detail. Two key factors that limited learning in the workplace were time and work priorities. Conclusion: it is recommended that a combination of learning strategies is useful and valuable in developing the nurse's skills and knowledge of continence care, if time and funding are available.
The importance of genotoxicity tests in new drug development process<p>Genotoksisite testlerinin yeni ilaç geliştirme sürecindeki önemi
Authors: Şen Selen , Beceren Ayfer , Aksoy Hüseyin 
Published: August 2018

In the preclinic investigation period at the beginning of the drug development process, it is an obligation to subject candidate drugs to genotoxicty investigations. Genotoxicty data of drugs that are developed with these tests are demanded as a part of the security evaluation process by regulatory authorities in various countries. The demand of these laboring and costly data by regulatory authorities of various countries in different standards prevents potential candidate drugs from being marketed, interrupts the drug development process and causes unnecessary utilization of experimental materials in researches. Therefore, nowadays, it is generally accepted that the researches aimed at achieving these data are implemented with standardized approaches in the guidelines of international harmonisation organizations such as ICH (International Council for Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use) and OECD (Organisation for Economic Cooperation and Development). In this review, it is aimed to provide current information about the various genotoxicity tests which are used commonly in the drug development process, in accordance with ICH, OECD guidelines and literature. Extended English summary is in the end of Full Text PDF (TURKISH) file.Özetİlaç geliştirme sürecinin başlangıcındaki preklinik araştırma döneminde, aday ilaçların genotoksisite testlerinden geçirilmesi bir zorunluluktur. Bu testlerle elde edilen genotoksisite verileri, çeşitli ülkelerdeki düzenleyici otoriteler tarafından güvenlilik değerlendirme sürecinin bir parçası olarak istenmektedir. Elde edilmesi oldukça zahmetli ve maliyetli olan bu bilgilerin, farklı ülkelerin düzenleyici otoriteleri tarafından değişik standartlarda istenmesi, potansiyel ilaç adaylarının pazarlamasını engellemekte, ilaç geliştirme sürecini kesintiye uğratmakta ve araştırmalarda gereksiz yere deney materyali kullanımına neden olmaktadır. Bu bakımdan, günümüzde bu bilgileri elde etmeyi amaçlayan araştırmaların, ICH (İnsanda Kullanılan İlaçların Ruhsatlandırılması İçin Teknik Gerekliliklerin Uyumlandırılması Uluslararası Birliği) ve OECD (Ekonomik Kalkınma ve İşbirliği Örgütü) gibi uluslararası harmonizasyon örgütlerinin kılavuzlarında standardize edilen yaklaşımlarla uygulanması genel kabul görmektedir. Bu derlemede, ilaç geliştirme sürecinde kullanılan genotoksisite testlerine ilişkin, ICH, OECD kılavuzları ve literatür ışığında güncel bilgiler verilmesi amaçlanmıştır.
Perbandingan Karakter Ekologi OPT (Organisme Pengganggu Tanaman) Dan Musuh Alaminya Pada Masa Tanam Yang Berbeda Di Sawah Organik Dan Anorganik
Authors: Hadi Mochamad 
Published: August 2018

Kualitas dan kuantitas tanaman padi sebagai produsen dalam jaring makanan akan mengundang hadirnya serangga herbivore sebagai konsumen pertama. Hadirnya serangga herbivore atau sering disebut OPT (Organisme Pengganggu Tanaman) di ekosistem sawah akan mengganggu produktivitas tanaman padi. Namun demikian hadirnya OPT di ekosistem sawah juga akan mengundang serangga musuh alaminya sebagai konsumen tingkat kedua, baik predator maupun parasitoiid, yang akan mengontrol keberadaan OPT. Pertanian organik adalah manajemen pertanian yang meniadakan penggunaan bahan kimia sintetik sebagai sarana produksi, baik berupa pupuk maupun pestisida. Penelitian bertujuan untuk mengetahui bagaimana karakter ekologi serangga OPT dan musuh alaminya pada masa tanam yang berbeda yaitu padi dan palawija pada sawah organik dan anorganik. Karakter ekologi dianalisis dengan jumlah jenis, jumlah individu, indeks keragaman (H’), kelimpahan (Di) dan kemerataan (e). Hasil penelitian menunjukkan bahwa secara umum karakter ekologi OPT dan musuh alami di dua masa tanam yang berbeda hampir sama, baik di sawah organik maupun anorganik. Jumlah jenis maupun jumlah individu OPT dan musuh alaminya di sawah organik maupun anorganik pada dua masa tanam yang berbeda juga menunjukkan hasil yang hampir sama. Keragaman dan kemerataan persebaran OPT dan musuh alaminya juga tidak berbeda pada kedua masa tanam yang berbeda. Namun demikian pada kedua masa tanam menunjukkan perbedaan dalam jenis OPT maupun musuh alaminya yang hadir, namun antara sawah organik dengan sawah anorganik tidak menunjukkan perbedaan. Kata kunci : OPT, musuh alami, masa tanam, sawah organik dan sawah anorganik.
Pengaruh Suhu Pengeringan Terhadap Kadar Air, Kadar Flavonoid dan Aktivitas Antioksidan Daun dan Umbi Rumput Teki (Cyperus rotundus L.)
Authors: Syafrida Mulia , Darmanti Sri , Izzati Munifatul 
Published: August 2018

Jatibarang Reservoir is a dam built in Talun Kacang village, Kandri, Gunung Pati, Semarang t with the aim of Water Resources Management and flood control in Semarang City. The presence of Zooplankton in a waters has a close relationship with water quality and its interaction in the environment.The research aimed to find out the distribution and diversity of Zooplankton species in Jatibarang reservoir waters. The method used is Purposive Random Sampling method by dividing the sampling point into 4 research stations, namely Dermaga zone, middle zone, inlet zone, and outlet zone. From the result of this research, we get the type of zooplankton Brachionus sp., Cylops sp., Collotecha sp., Conochilus sp., Daphnia sp., Harringia sp., Rotaria sp., Keratella sp. and species from the Asphlanchnidae (Asphlanchinii) and Trichotriidae Family. The species diversity in Jatibarang reservoirs in each zone is low with abundance between 30-80 ind / L and the equalization and dominance of each low species. The dominant species is Brachionus sp. and Cyclops sp. Water quality measurement results show the waters of Jatibarang reservoir is good for the life of aquatic biota Keywords: Zooplankton, Jatibarang Reservoir, Diversity.
Struktur Komunitas Makrobentos Pada Kawasan Budidaya dan Non Budidaya Di Pulau Tembelas, Kabupaten Karimun Kepuluan Riau
Authors: Prahmawaty Raden Faradhiva , Putro Sapto Punomo 
Published: August 2018

The macrobenthos community structure of living organisms in aquatic base, can function as a bioindicator of changes in aquatic environments, are sensitive to any disturbance of environmental changes within a waters. This research aims to determine the effect of different structures of macrobenthos communities in the cultivation environment and noncultivation environment. The research was conducted for 4 months on Tembelas island in 2 areas that were monoculture cultivation and reference area. Abiotic data obtained were substrate grain analysis and total organic analysis of carbon and nitrogen, as well as abiotic environmental parameters such as temperature, pH, salinity and dissolved oxygen. The biotic data obtained in the form of macrobenthos species that were found and the amount in the area was then calculated using non parametric index that were the level of diversity, eveness and abundance, and T test. The identification result showed the number of species found as many as 24 species in the monoculture location and 42 species at the reference location. Dominant species found in monoculture locations were Costoanachis sp and Anodontia sp. dominant species found in the reference sites were Nuculana sp and Ellobium sp. Shannon-Wiener (H') diversity index value at monoculture location was 2,43, while reference index value index had bigger index value 2,83. The abiotic quality of monoculture and reference aquatic environments was categorized as good. Based on the result of the research, it can be concluded that reference environment had better macrobenthos diversity value than monoculture environment. Keywords: Makrobenthos, Monoculture, Reference Environment
Utilization of Ficus benjamina by Birds at Urban Habitat in Depok
Authors: Pradana Dimas Haryo , Mardiastuti Ani , Yasman Y 
Published: August 2018

Most of the research about the relationship of birds and figs were conducted at natural habitat. We conducted a research about this relationship at urban habitat in Depok and specifically studied utilization of Ficus benjamina by birds as feeding and nesting tree. The objective of our research was to describe the F. benjamina utilization by urban birds in Depok. Scans sampling and nest counting were used during this study. Our research shows that F. benjamina was used as feeding tree by most of birds which lives at urban habitat in Depok. Our research also shows that some birds used this fig species as nesting tree. Key Words : birds, Ficus benjamina, urban, Java
ANALISA TEKNIS DAN EKONOMIS PEMILIHAN MANAJEMEN AIR BALLAS PADA KAPAL (SHIP BALLAST WATER MANAGEMENT) DI INDONESIA
Authors: Arif Mohammad Sholikhan , Kurniawati Hesty Anita , Misbah M. Nurul 
Published: August 2018

Peraturan yang mengatur dan manajemen dari air ballas dikeluarkan oleh IMO (International Maritime Organization) melalui konvensi Manajemen air ballas. Konvensi tersebut menyatakan bahwa organisme yang berbahaya terhadap lingkungan, kesehatan manusia, properti atau sumber daya merusak keanekaragaman hayati atau mengganggu pemanfaatan terhadap suatu area jika dilepaskan di air laut. Pemerintah Republik Indonesia mengeluarkan Peraturan Presiden No. 132 tahun 2015 mengenai pengesahan Konvensi internasional untuk pengendalian dan manajemen air ballas dan sedimen dari kapal 2004 (The International Convention for the control and management of ships ballast water and sediment’s 2004). Penelitian ini bertujuan untuk menganalisa sejauh mana kesiapan Indonesia dalam ratifikasi peraturan (come into force) Ballast water Management serta dampak yang diakibatkan setelah peraturan tersebut diratifikasi. Metode yang dilakukan dalam penelitian ini menggunakan 3 pendekatan yaitu dari aspek hukum, aspek teknis dan aspek ekonomis. Hasil dari penelitian ini adalah Peraturan Pemerintah Nomor 21 Tahun 2010 tentang Perlindungan Lingkungan Maritim sebagai jabaran dari Undang-Undang Nomor 17 Tahun 2008 tentang Pelayaran, telah sejalan dengan Konvensi Internasional untuk Pengendalian dan Manajemen Air Ballas dan Sedimen dari Kapal, 2004 dan Undang-Undang Nomor 17 Tahun 1985 tentang pengesahan United Nations Convention on the LAW of the Sea (UNCLOS). Serta Penggunaan sistem manajemen air ballas untuk kapal di perairan Indonesia lebih efektif dan efisien menggunakan filtration + electrolysis
A numerical analysis of heat transfer in a cross-current heat exchanger with controlled and newly designed air flows
Authors: Żukowski Witold , Migas Przemysław , Gwadera Monika , Larwa Barbara , Kandafer Stanisław 
Published: August 2018

AbstractSimulations of heat transfer between air and flue gases in a plate heat exchanger are presented. The device was designed for the heating of the air supplying a fluidised furnace for the combustion of wet sludge and wood crumbs. The locations of inlets and outlets and the geometry of the heat exchanger are determined by the construction of the furnace. The aim of the simulations was to increase effectiveness of heat transfer through the use of flow redirections with additional baffles placed in the air chamber. The results of the simulations showed that a substantial part of the heat exchanger without baffles is not used effectively. On the basis of a velocity profile, a temperature distribution and a wall heat flux, the geometry of the inter-plate space within the air chamber was modified by adding baffles. The unmodified exchangers had 77% efficiency in comparison to counter-current exchangers with the same heat transfer area. After the application of baffles, the efficiency increased to 83-91% depending on the construction used (one, two or three baffles). The best model variant of the exchanger with baffles led to the increase in the temperature of air supplying the fluidised bed by approximately 76 K in relation to the system without baffles . Unexpectedly, the presented modifications of the geometry of the system had very low influence of the flow resistance in the air chamber. The value of Δp for the system without baffles is almost the same as for the best model variant.
Improvement of fuel properties of biodiesel with bioadditive ethyl levulinate
Authors: Unlu Derya , Boz Nezahat , Ilgen Oguzhan , Hilmioglu Nilufer 
Published: August 2018

AbstractBiodiesel has poor cold flow properties due to their high saturated fatty acid content. Ethyl levulinate is used as bio-based cold flow improver additive in biodiesel. In this work, both ethyl levulinate and biodiesel were synthesized in the laboratory. Ethyl levulinate was added to the biodiesel at different rates, i.e, 5, 10, 15, 20 (vol %). The effect of ethyl levulinate addition on density, kinematic viscosity, acid value, cloud point and pour point was determined and compared to the EN 14214 and ASTM D6751 specification. Consequently, ethyl levulinate appears acceptable as a cold flow improver for biodiesel fuel.
Calculating the Degree-based Topological Indices of Dendrimers
Authors: Kang Shin Min , Zahid Manzoor Ahmad , Virk Abaid ur Rehamn , Nazeer Waqas , Gao Wei 
Published: August 2018

Abstract
Topological indices capture the symmetry of molecular structures and provide a mathematical language to predict properties such as boiling points, viscosity, the radius of gyrations etc. [1]. We compute some newly developed topological indices of Porphyrin, Propyl Ether Imine, Zinc-Porphyrin and Poly(EThyleneAmidoAmine) Dendrimers. The results are plotted using Maple 2015 software to see the dependence on the involved structural parameters.
Efficient optimization and mineralization of UV absorbers: A comparative investigation with Fenton and UV/H2O2
Authors: Sahar Anum , Ali Shaukat , Hussain Tanveer , Jahan Nazish , Zia Muhammad Anjum 
Published: August 2018

AbstractUV absorbers developed for finishing of textile materials play a significant role in protection against UV radiations but their discharge in wastewater during processing and laundry action also retain serious concern to living species due to their recalcitrant nature. The current study examined the mineralization and degradation of two vinylsulfone and nitrogen (N-) containing UV absorber compounds (1a, 2a) via two effective Fenton and UV/H2O2 oxidation. The results showed that both the Fenton and UV/H2O2 processes mineralized the synthesized UV absorbers effectively; however the mineralization process with Fenton oxidation was more effective than the UV/H2O2. The mineralization of synthesized UV absorbers was affected by process parameters (dosage of Fe2+ and H2O2 pH and reaction time). Under attained optimum conditions of Fenton oxidation, dose of Fe2+ (15 mg/L), H2O2 (500 mg/L), pH (3.0) and contact time (120 minutes), 75.43 and 77.54% of Chemical Oxygen Demand removal was achieved for 1a and 2a, respectively. Whereas, the optimum conditions of UV/H2O2 process were H2O2 (700 mg/L), pH(3.0) and irradiation time (200 minutes) that brought 54.33 and 57.65% COD removal in case of 1a and 2a, respectively. The results indicated that the Fenton oxidation can be successfully employed for the mineralization of triazine based UV absorbers.
Adsorption and determination of polycyclic aromatic hydrocarbons in water through the aggregation of graphene oxide
Authors: Han Bingjun , Li Ya , Qian Bing , He Yan , Peng Lixu , Yu Huamei 
Published: August 2018

Abstract
In this study, a simple method was developed for the aggregation of graphene oxide (GO) with the addition of NaCl to concentrate and separate polycyclic aromatic hydrocarbons (PAHs) from water samples, and this method was used as a environmentally friendly method for the determination of PAHs. We demonstrate the uniform dispersion of GO sheets in aqueous samples for the fast high-efficiency adsorption of PAHs. Aggregation occurred immediately upon elimination of electrostatic repulsion by adding NaCl to neutralize the excessive negative charges on the surfaces of the GO sheets. The aggregates of GO and PAHs were separated and treated with hexane to form a slurry. The slurry was filtered and subjected to gas chromatography–mass spectroscopy (GC-MS) analysis. Based on a 40-mL sample volume, limits of detection of 10–30 ng L-1 were obtained for 16 PAHs, with correlation coefficients (R2) exceeding 0.99. The method yielded good recovery, ranging from 80 to 111% and 80 to 107% for real spiked water samples at 100 and 500 ng L-1, respectively. Compared to traditional solid-phase extraction and liquid–liquid extraction methods, this method is free of organic reagents in the pretreatment procedure and uses only 1 mL hexane for sample introduction.
Ad hoc categorization in Russian and multifunctional general extenders
Authors: Benigni Valentina 
Published: August 2018

AbstractRussian, as well as many other languages, displays a wide number of strategies to name non-lexicalized categories, that is, categories which have a conceptual reality, but are not encoded as single lexical items (e.g.fruit, furniture) or set phrases (e.g.equipment for sport, food for dog). One way to address this lack of lexical means is to provide one or more concrete exemplars of the intended category, in an attempt to capture the superordinate non-lexicalized concept. This paper aims to provide an overview of the different generalizing means used in Russian for the online construction of exemplar-driven categories, and, at the same time, to explore the interplay between discourse-resources (e.g. exemplification, listing and reformulation) and system-resources (e.g. collective affixation, co-compounding and discourse markers) in the process of categorization. Particular attention will be focused on the description of schematic general extenders, that is, partially lexicalized syntactic patterns, realizing the different extending, generalizing and similative functions of general extenders. The last part of the paper is devoted to a discussion of the processes of grammaticalization and pragmaticalization of the general extenderi vse takoe‘and so on’ (lit. ‘and all such’). The form is interesting because of its discursive multifunctionality.