bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organização de recursos bibliográficos e multimídia na web: contribuições interdisciplinares
Authors: Lemos Daniela Lucas da Silva , Souza Renato Rocha 
Published: December 2018

Introdução: O artigo elucida a fertilização cruzada de tecnologias, teorias e metodologias interdisciplinares endereçada ao processo de construção de modelos ontológicos de qualidade centrados no usuário e destinados à representação de recursos bibliográficos e multimídia na Web. Objetivo: Apresentar as interlocuções de disciplinas seminais à área da organização da informação e do conhecimento oriundas dos campos da Ciência da Informação e da Ciência da Computação mostrando, em especial, o avanço contínuo da catalogação descritiva para ambientes de informações digitais, propiciando, assim, melhorias nos sistemas de recuperação da informação. Metodologia: A pesquisa foi delineada a partir de um levantamento bibliográfico e documental à luz de literatura específica, buscando explorar, descrever e explicar o fenômeno presente no campo da realidade documental em ambientes digitais. Resultados: O panorama atual concernente à representação de documentos bibliográficos e multimídia na Web indica a participação efetiva de dois campos de conhecimento – a Ciência da Informação e a Ciência da Computação – juntamente com suas disciplinas e princípios teóricos e metodológicos imprescindíveis para a evolução dos metadados às anotações semânticas. Conclusões: Os produtos e processos da organização e representação da informação e do conhecimento apresentados e discutidos no artigo mostraram a importância histórica e interdisciplinar de disciplinas fundadoras bem como tecnológicas no progresso da área de tratamento da informação. Tais disciplinas, como a representação descritiva, representação temática e modelagem conceitual contribuem sobremaneira com seus princípios teóricos e metodológicos no processo de construção de modelos ontológicos destinados a representar semanticamente documentos de natureza bibliográfica e multimídia na Web.
Samfundets trosbekendelse
Authors: Korsgaard Ove 
Published: December 2018

After World War II, there was broad consensus that schools in Denmark should educate for democracy. But there was no consensus on the role of the state: Should the state ensure that everyone receives a democratic education? Or should the state ensure pluralism, and remain neutral in relation to different life philosophies? Or must both the state and citizens develop a knowledgeable stance in relation to democracy’s fundamental dilemmas? It was without doubt the liberal position that became most influential in post-war Danish educational policy. The core of this strategy was that in a democracy the state should adopt a neutral stance towards the various philosophies of life. However, with the values-political turn of recent years the liberal position is now in retreat. This new trend became clear in 2000, with the then Minister of Education Margrethe Vestager’s manifesto Values in the Real World, in which she stressed that „Now more than ever we need to put in words just what attitudes and values we hold in common“. And the present government has focused on the same issue since 2001, and has commissioned among other things a literary canon, a cultural canon and a democracy canon. The activist values policies of recent years have once again given rise to a number of questions concerning democratic upbringing and the role of the state in efforts to strengthen society’s cohesiveness.
Making room for change: Spatial tactics and the micropolitics of inhabiting organisational space
Authors: Clausen Rune Thorbjørn , Elmholdt Kasper Trolle 
Published: December 2018

Literature on organisational space has pointed at the political nature of space. In this article, we explore the relation between the physical space of organisations and change. Through a case study of a media company that successfully designed a new headquarters with the aspiration to become an open, coherent and transparent organisation, we describe and analyse the micropolitics of organisational space. Using the concept of ‘spatial tactics’, we explain how initial intentions with the building design were resisted and renegotiated at the micro level as employees began inhabiting organisational space, by which, we argue, room for change was made. The study contributes to the literature on space and organisational change by providing an empirical account of how spatial tactics matter for making buildings work in change initiatives.
Consumo alimentar de idosos residentes na zona rural do município de Caxias do Sul, RS
Authors: Marchesi Gabriela Schmitt , Conde Simara Rufatto 
Published: December 2018

Introdução: O Brasil apresenta um grande índice de envelhecimento populacional, característica que envolve grandes desafios, sendo um deles o processo de alimentação. Idosos que residem na zona rural possuem maior oferta de alimentos in natura, fato que ocorre pelo cultivo dos mesmos em suas residências. Objetivo: Avaliar o perfil alimentar da população idosa residente na zona rural do Município de Caxias do Sul. Métodos: Estudo transversal cuja amostra se deu por conveniência, composta por 16 idosos de ambos os gêneros que participaram do projeto Conviver. Foi avaliado o estado mental dos participantes através do Mini Exame do Estado Mental e a ingestão alimentar por meio do recordatório alimentar de 24 horas com relato de três dias. Os dados foram analisados estatisticamente através do Teste t de Student e do Teste de Mann-Whitney através do software SPSS versão 22. Resultados: O consumo de processados e ultraprocessados pelos idosos representou 30,28% do valor energético total. Os idosos apresentaram consumo acima do estabelecido pela DRI para carboidratos e abaixo para lipídios, cálcio, fibras, vitaminas A, B6 e B12. A ingestão de proteína, sódio, ferro e vitamina C estavam dentro das recomendações. Conclusão: Os idosos participantes do estudo apresentam uma alimentação rica em carboidratos, porém com deficiências de micronutrientes.
Impact of Cyclic Citrullinated Peptide Antibody Level on Progression to Rheumatoid Arthritis in Clinically Tested Cyclic Citrullinated Peptide Antibody–Positive Patients Without Rheumatoid Arthritis
Authors: Ford Julia A. , Liu Xinyi , Marshall Allison A. , Zaccardelli Alessandra , Prado Maria G. , Wiyarand Charlene , Lu Bing , Karlson Elizabeth W. , Schur Peter H. , Deane Kevin D. , Sparks Jeffrey A. 
Published: December 2018

ObjectiveTo investigate the risk of progression to rheumatoid arthritis (RA) in patients who were cyclic citrullinated peptide (CCP) antibody positive without RA at initial presentation.MethodsWe performed a retrospective cohort study of CCP+ individuals seen at a US tertiary care system between 2009 and 2018 who were without RA or other systemic rheumatic disease by medical record review at the time of CCP antibody positivity. Progression to classifiable RA was determined through medical record review. We investigated the risk of progression to RA overall and stratified by CCP antibody level (low: >1 to 2× the upper limit of normal [ULN]; medium: >2 to 3× ULN; high: >3× ULN). Multivariable Cox regression estimated the hazard ratio (HR) and 95% confidence interval (95% CI) for RA by CCP antibody level.ResultsWe identified 340 CCP+ patients who were without RA or other rheumatic disease at baseline. During 1,047 person‐years of follow‐up, 73 patients (21.5%) developed RA. The risk of progression to RA increased with CCP antibody level, with 46.0% (95% CI 34.7–55.3) of patients with high‐level CCP antibodies progressing to RA by 5 years. Compared to low CCP antibody level, medium (HR 3.00 [95% CI 1.32–6.81]) and high (HR 4.83 [95% CI 2.51–9.31]) CCP antibody levels were strongly associated with progression to RA, adjusting for age, sex, body mass index, smoking, family history of RA, and rheumatoid factor level.ConclusionAmong CCP+ patients without RA, the risk for progression to RA increased substantially with increasing CCP antibody level. This study provides further support for close monitoring for development of RA among CCP+ patients and identifying strategies to mitigate this risk.
Weak Interlayer Interaction in 2D Anisotropic GeSe2
Authors: Yang Yusi , Wang Xia , Liu Shun‐Chang , Li Zongbao , Sun Zhaoyang , Hu Chunguang , Xue Ding‐Jiang , Zhang Gengmin , Hu Jin‐Song 
Published: December 2018

AbstractGermanium diselenide (GeSe2) has recently emerged as a new member of in‐plane anisotropic 2D materials, notable for its wide bandgap of 2.74 eV, excellent air stability, and high performance in polarization‐sensitive photodetection. However, the interlayer interaction in GeSe2 has never been reported, which usually plays an important role in layer‐number‐dependent physical properties. Here, the interlayer coupling in GeSe2 is systematically investigated from theory to experiment. Unexpectedly, all of density functional theory (DFT) calculations about layer‐dependent band structures, cleavage energy, binding energy, translation energy, and interlayer differential charge density demonstrate the much weaker interlayer interaction in GeSe2 when compared with black phosphorus (BP). Furthermore, both thickness‐dependent and temperature‐dependent Raman spectra of GeSe2 flakes, which exhibit no detectable changes of Raman peaks with the increase in thickness and a small first‐order temperature coefficient of −0.0095 cm−1 K−1, respectively, experimentally confirm the weakly coupled layers in GeSe2. The results establish GeSe2 as an unusual member of in‐plane anisotropic 2D materials with weak interlayer interaction.
Patients with SATB2‐associated syndrome exhibiting multiple odontomas
Authors: Kikuiri Takashi , Mishima Hiroyuki , Imura Hideto , Suzuki Satoshi , Matsuzawa Yusuke , Nakamura Takashi , Fukumoto Satoshi , Yoshimura Yoshitaka , Watanabe Satoshi , Kinoshita Akira , Yamada Takahiro , Shindoh Masanobu , Sugita Yoshihiko , Maeda Hatsuhiko , Yawaka Yasutaka , Mikoya Tadashi , Natsume Nagato , Yoshiura Koh‐ichiro 
Published: December 2018

Abstract
Special AT‐rich sequence‐binding protein 2 (SATB2)‐associated syndrome (SAS) is characterized by alterations of SATB2. Its clinical features include intellectual disability and craniofacial abnormalities, such as cleft palate, dysmorphic features, and dental abnormalities. Here, we describe three previously undiagnosed, unrelated patients with SAS who exhibited dental abnormalities, including multiple odontomas. Although isolated odontomas are common, multiple odontomas are rare. Individuals in families 1 and 3 underwent whole‐exome sequencing. Patient 2 and parents underwent targeted amplicon sequencing. On the basis of the hg19/GRCh37 reference and the RefSeq mRNA NM_001172517, respective heterozygous mutations were found and validated in Patients 1, 2, and 3: a splice‐site mutation (chr2:g.200137396C > T, c.1741‐1G > A), a nonsense mutation (chr2:g.200213750G > A, c.847C > T, p.R283*), and a frame‐shift mutations (chr2:g.200188589_200188590del, c.1478_1479del, p.Q493Rfs*19). All mutations occurred de novo. The mutations in Patients 1 and 3 were novel; the mutation in Patient 2 has been described previously. Tooth mesenchymal cells derived from Patient 2 showed diminished SATB2 expression. Multiple odontomas were evident in the patients in this report; however, this has not been recognized previously as a SAS‐associated phenotype. We propose that multiple odontomas be considered as an occasional manifestation of SAS.
Selective Functionalization of Graphene at Defect‐Activated Sites by Arylazocarboxylic tert‐Butyl Esters
Authors: Halbig Christian E. , Lasch Roman , Krüll Jasmin , Pirzer Anna S. , Wang Zhenping , Kirchhof Jan N. , Bolotin Kirill I. , Heinrich Markus R. , Eigler Siegfried 
Published: December 2018

AbstractThe development of versatile functionalization concepts for graphene is currently in the focus of research. Upon oxo‐functionalization of graphite, the full surface of graphene becomes accessible for C−C bond formation to introduce out‐of‐plane functionality. Herein, we present the arylation of graphene with arylazocarboxylic tert‐butyl esters, which generates aryl radicals after activation with an acid. Surprisingly, the degree of functionalization is related to the concentration of lattice vacancy defects in the graphene material. Consequently, graphene materials that are free from lattice defects are not reactive. The reaction can be applied to graphene dispersed in solvents and leads to bitopic functionalization as well as monotopic functionalization when the graphene is deposited on surfaces. As the arylazocarboxylic tert‐butyl ester moiety can be attached to various molecules, the presented method paves the way to functional graphene derivatives, with the density of defects determining the degree of functionalization.
Kräfte in Form bringen
Authors: Kleiser Michael , Jusufagic Hinko , Pölcz Roman , König Dieter , Musil Christian 
Published: December 2018

AbstractIm Zuge des Neubauabschnitts der Nord/Weinviertler Autobahn A5 nördlich von Wien wurde eine Überführungsbrücke als sichtbare Streckenmarke durch den österreichischen Autobahnbetreiber ASFINAG errichtet. Die Gestaltung zielt auf eine Entfaltung der Tragwirkung in der Form ab, um nach außen einen höchstmöglichen Ausdruck der Authentizität und Dynamik zu erreichen. Beim Entwurf sind dabei Erkenntnisse aus der Gestaltpsycholgie eingeflossen, die die Verbildlichung der Vorgänge des Tragens und Lastens als entsprechendes Wahrnehmungserlebnis ausweist. Mit dieser Brücke soll beispielhaft gezeigt werden, dass trotz der immensen Richtlinien‐ und Normenflut im heutigen zeit‐ und kostengetriebenen Fließbandingenieurzeitalter Anwendungen möglich sind, die die grundsätzliche statisch‐konstruktive Aufgabe mit einer gestaltgebenden Tätigkeit verbindet. In diesem Artikel wird der Prozess von der Idee über den Entwurf bis zur Umsetzung erläutert.
Evaluating the collection, comparability and findings of six global surgery indicators
Authors: Holmer H , Bekele A , Hagander L , Harrison E M , Kamali P , Ng-Kamstra J S , Khan M A , Knowlton L , Leather A J M , Marks I H , Meara J G , Shrime M G , Smith M , Søreide K , Weiser T G , Davies J 
Published: December 2018

Abstract

Background
In 2015, six indicators were proposed to evaluate global progress towards access to safe, affordable and timely surgical and anaesthesia care. Although some have been adopted as core global health indicators, none has been evaluated systematically. The aims of this study were to assess the availability, comparability and utility of the indicators, and to present available data and updated estimates.

Methods
Nationally representative data were compiled for all World Health Organization (WHO) member states from 2010 to 2016 through contacts with official bodies and review of the published and grey literature, and available databases. Availability, comparability and utility were assessed for each indicator: access to timely essential surgery, specialist surgical workforce density, surgical volume, perioperative mortality, and protection against impoverishing and catastrophic expenditure. Where feasible, imputation models were developed to generate global estimates.

Results
Of all WHO member states, 19 had data on the proportion of the population within 2h of a surgical facility, 154 had data on workforce density, 72 reported number of procedures, and nine had perioperative mortality data, but none could report data on catastrophic or impoverishing expenditure. Comparability and utility were variable, and largely dependent on different definitions used. There were sufficient data to estimate that worldwide, in 2015, there were 2 038 947 (i.q.r. 1 884 916–2 281 776) surgeons, obstetricians and anaesthetists, and 266·1 (95 per cent c.i. 220·1 to 344·4) million operations performed.

Conclusion
Surgical and anaesthesia indicators are increasingly being adopted by the global health community, but data availability remains low. Comparability and utility for all indicators require further resolution.
Sanhuang Xiexin decoction promotes good functional outcome in acute ischemic stroke
Authors: Song Juexian , Chen Xin , Lyu Yi , Zhuang Wei , Zhang Jing , Gao Li , Tong Xiaolin 
Published: December 2018

AbstractObjectivesTo explore the efficiency and safety of Sanhuang Xiexin decoction in the treatment of acute ischemic stroke (AIS) patients after endovascular intervention examination.MethodsIn this prospective observational study, 121 AIS patients admitted in our hospital were enrolled from January 2012 to December 2015. They were randomly divided into two groups, 61 patients received Sanhuang Xiexin decoction + basic treatment (SX group) and 60 patients received basic treatment (control group). The prescription of Sanhuang Xiexin decoction was taken in the SX group, with one dose (100 ml), twice a day for 7 days orally. For all patients, blood samples were drawn on the first morning and sixth morning after endovascular intervention examination under fasting state for Fib (fibrinogen), PAgT (platelet aggregation test), CRP (C‐reactive protein), and TMAO (trimethylamine oxide) tested. Estimate the changes in plasma Fib, PAgT, CRP, and TMAO levels and the syndrome of fire‐heat scores.ResultsThe plasma Fib, PAgT, CRP, and TMAO levels in the SX group were significantly lower than those in the control group (PFib < 0.01, PPAgT < 0.01, PCRP = 0.02, PTMAO < 0.01). The syndrome of fire‐heat scores in the SX group was significantly lower than that in the control group (p < 0.01). The incidences of ischemic cerebrovascular events within 3 and 6 months after endovascular intervention treatment in the SX group were lower than those in the control group (P3 month = 0.04, P6month = 0.03).ConclusionsThe prescription of Sanhuang Xiexin is efficient and safe in the treatment of AIS patients after endovascular intervention examination through reducing the inflammatory factors.
Positive affective priming decreases the middle late positive potential response to negative images
Authors: Hill Lauren D. , Starratt Valerie G. , Fernandez Mercedes , Tartar Jaime L. 
Published: December 2018

AbstractIntroductionThis study aims to expand on previous literature showing that incidental emotion state priming in a specific domain leads to a higher probability that the primed emotion domain will be activated during a subsequent task.MethodsTo that end, we investigated the influence of happy, fearful, and neutral incidental emotion state priming on subsequent responses to emotionally negative and neutral pictures, measured by the event‐related potential (ERP) late positive potential (LPP). New to our study, we examined the influence of affective priming on the LPP response (analyzed separately at early and middle latency ranges) to emotional pictures in both the foveal and extrafoveal presentation locations.ResultsFollowing both fearful and neutral incidental state priming, both the early and middle LPP latency ranges overwhelmingly differentiated between negative and neutral pictures. Following happy incidental state priming, however, the LPP response failed to differentiate between negative and neutral pictures by the middle LPP latency range (800–1,000 ms). These results suggest that incidental happy states can have a protective effect when viewing aversive stimuli. Additionally, the LPP showed greater sensitivity to negative stimuli when presented extrafoveally compared to foveally.ConclusionsOverall, our findings suggest that incidental affective state and stimulus location influence emotional processing differentially for emotionally negative and emotionally neutral stimuli.
Clinical features of lenvatinib for unresectable hepatocellular carcinoma in real‐world conditions: Multicenter analysis
Authors: Hiraoka Atsushi , Kumada Takashi , Kariyama Kazuya , Takaguchi Koichi , Atsukawa Masanori , Itobayashi Ei , Tsuji Kunihiko , Tajiri Kazuto , Hirooka Masashi , Shimada Noritomo , Shibata Hiroshi , Ishikawa Toru , Ochi Hironori , Tada Toshifumi , Toyoda Hidenori , Nouso Kazuhiro , Tsutsui Akemi , Itokawa Norio , Imai Michitaka , Joko Kouji , Hiasa Yoichi , Michitaka Kojiro ,   the Real‐life Practice Experts for HCC (RELPEC) Study Group, HCC 48 Group (hepatocellular carcinoma experts from 48 clinics in Japan)
Published: December 2018

AbstractBackground/AimPresently, there are no therapeutic options for unresectable hepatocellular carcinoma (u‐HCC) patients who are intolerant to sorafenib or regorafenib failure. There have been no reports with detailed clinical findings of lenvatinib (LEN), a newly developed first‐line tyrosine kinase inhibitor (TKI), obtained in real‐world practice. We aimed to elucidate the therapeutic efficacy of LEN.Materials/MethodsFrom March to August 2018, 105 u‐HCC patients were treated with LEN. Following exclusion of those who started with a reduced LEN dose and/or had a short observation period (<2 weeks), 77 patients (72.0 ± 8.9 years, 59 males, 8 mg/12 mg = 49/28, Liver Cancer Study Group of Japan 6th [LCSGJ]‐TNM stage II/III/IVa/IVb = 8/28/4/37, and American Joint Committee on Cancer/Union for International Cancer Control 8th [AJCC/UICC]‐TNM stage IB:II:IIIA:IIIB:IVA:IVB = 2:27:6:5:9:28) were divided into two groups (TKI naïve [n = 33] and TKI experienced [n = 44], including 11 with regorafenib history). Therapeutic response was evaluated using mRECIST. Clinical data were retrospectively evaluated.ResultsThere were significant differences in age (74.6 ± 11.2 vs 70.0 ± 5.9 years, P = 0.040), LCSGJ‐TNM (II:III:IVa:IVb = 8:12:1:12 vs 0:16:3:25, P = 0.006), and AJCC/UICC‐TNM (IB:II:IIIA:IIIB:IVA:IVB = 2:17:1:1:4:8 vs 0:10:5:4:5:20, P = 0.028), while hepatic reserve function, adverse event (AE) profiles, and progression‐free survival (89.7%/80.4% vs 90.5%/80.1%, P = 0.499) and overall survival (96.7%/96.7% vs 100%/92.3%, P = 0.769) after 4 and 12 weeks were not significantly different between the TKI‐naïve and TKI‐experienced groups. Overall response rate and disease control rate at 4 weeks (n = 52) were 38.5% and 80.8%, respectively, and 32.4% and 70.3%, respectively, at 12 weeks (n = 37). A significant decline in log10 AFP from the baseline to 4 weeks after introducing LEN was observed in patients with PR and SD (2.047 ± 1.148 vs 1.796 ± 1.179, P < 0.001).ConclusionRegardless of past TKI therapy, therapeutic response and AEs after introducing LEN were similar. LEN may be an important treatment for the present unmet need regarding TKI treatment against u‐HCC.
The prognostic significance of PFS24 in follicular lymphoma following firstline immunotherapy: A combined analysis of 3 CALGB trials
Authors: Lansigan Frederick , Barak Ian , Pitcher Brandelyn , Jung Sin‐Ho , Cheson Bruce D. , Czuczman Myron , Martin Peter , Hsi Eric , Schöder Heiko , Smith Scott , Bartlett Nancy L. , Leonard John P. , Blum Kristie A. 
Published: December 2018

AbstractFollicular lymphoma (FL) patients treated with firstline R‐CHOP who experience progression of disease (POD) within 2 years have a shorter survival than those who do not have POD within 2 years. Whether this observation holds for patients treated initially with biologic immunotherapy alone is unknown. We performed a retrospective analysis of 174 patients pooled from three frontline rituximab (R)‐based nonchemotherapy doublet trials: R‐galiximab (Anti‐CD80, CALGB 50402), R‐epratuzumab (Anti‐CD22, CALGB 50701), and R‐lenalidomide (CALGB 50803) to determine outcomes of early progressors and risk factors for early POD, defined as progression within 24 months from study entry. Twenty‐eight percent (48/174) of patients had early POD. After adjusting for the Follicular Lymphoma International Prognostic Index (FLIPI), patients with early POD from study entry had a worse OS compared with patients who did not progress within 2 years (HR = 4.33 (95% CI 1.50‐12.5), P = 0.007). For early POD, the 2‐year survival was 80% vs 99% for nonearly POD, and the 5‐year survival was 74% vs 90%, respectively. These findings suggest that the adverse survival of patients with early POD may be independent of initial treatment modality.