bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomical variants and coronary anomalies detected by dual-source coronary computed tomography angiography in North-eastern Thailand
Authors: Chaosuwannakit Narumol 
Published: October 2018

PurposeCongenital coronary anomalies are uncommon, with an incidence ranging from 0.17% in autopsy cases to 1.2% in angiographically evaluated cases. The recent development of dual-source coronary computed tomography angiography (coronary CTA) allows accurate and noninvasive depiction of coronary artery anomalies.Material and methodsA retrospective study included a total of 924 patients who underwent coronary CTA because of known or suspected coronary artery disease. In each study, coronary artery anomalies (CAs) were investigated.ResultsA total of 924 patients (mean age 51.2 ±12.8 years), who underwent dual-source coronary CTA, were studied. The overall prevalence of CAs in our study was 3.7%, with the following distribution: four single coronary artery, 14 anomalous origin from opposite sinus of Valsalva, three absent left main, four high take-off coronary artery, three anomalous left coronary artery from pulmonary artery, and eight coronary artery fistulas.ConclusionsThe present study supports the use of coronary CTA as a reliable noninvasive tool for defining anomalous coronary arteries in an appropriate clinical setting and provides detailed three-dimensional anatomic information that may be difficult to obtain with invasive coronary angiography.
Noninvasive evaluation of renal tissue oxygenation with blood oxygen level-dependent magnetic resonance imaging early after transplantation has a limited predictive value for the delayed graft function
Authors: Sławińska Agata , Serafin Zbigniew , Zawada Elżbieta , Białecki Marcin , Wypych Katarzyna , Woderska Aleksandra , Słupski Maciej , Włodarczyk Zbigniew 
Published: October 2018

PurposeThe aim of this study was to evaluate the feasibility of renal oxygenation assessment using blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) in the early period after kidney transplantation and to estimate its prognostic value for delayed graft function.Material and methodsExaminations were performed in 50 subjects: 40 patients within a week after the kidney transplantation and 10 healthy controls, using T2*-weighted sequence. Measurements in transplant patients were correlated to basic laboratory parameters in the early period after transplantation and at follow-up.ResultsExaminations of seven patients (18%) were rejected due to their poor technical quality. Mean R2* values in transplant recipients were lower than in controls (11.6 vs. 15.9 Hz; p = 0.0001). An R2* value of 0.28 Hz was calculated as the minimal detectable change. There was no relation between R2* values and laboratory parameters. However, patients eGFR ≥ 40 ml/min/1.73 m<sup>2</sup> presented higher R2* values than recipients eGFR < 40 ml/min/1.73 m<sup>2</sup> (12.0 vs. 11.1 Hz; p = 0.0189). In ROC analysis R2* of ≤ 11.7 predicted an early reduced graft function with 0.82 sensitivity and 56% specificity (AUC = 0.708; p = 0.024) but was not useful for delayed graft function prediction (p > 0.7).ConclusionsEvaluation of renal graft oxygenation using BOLD MRI is technically challenging in the early period after transplantation. An R2* value of 0.28 Hz may in practice be considered as the minimal detectable change. The delayed graft function seems not to be dependent on early oxygenation values. Further, large-scale studies are necessary to confirm the latter observation.
A AUTONOMIA DA GESTÃO DAS ENTIDADES GESTORAS DO FUTEBOL BRASILEIRO
Authors: Silva Lucas Do Monte 
Published: October 2018

Com o fracasso da seleção brasileira na busca pelo hexacampeonato na Copa do Mundo 2014, provocou-se diversos debates quanto a possibilidade de uma reformulação da Confederação Brasileira de Futebol (CBF) e, por extensão, da forma de gestão dos clubes brasileiros, bem como trouxe à tona discussões sobre o nível de autonomia que tais entes possuem no Brasil. Utiliza-se dessa derrota como um ponto de partida para uma mudança paradigmática na forma de gestão do esporte brasileiro e, mais especificamente, a gestão do esporte mais popular do Brasil, o futebol. Dessa discussão, sob uma ótica jurídica, engendra-se dois questionamentos, os quais servem de premissa lógica para responder a hipótese levantada pelo artigo: É viável a intervenção do Estado na gestão das entidades gestoras do futebol brasileiro? Caso ela seja possível, qual seria o limite da intervenção estatal nessa esfera, isto é, em quais âmbitos seria positiva a ingerência do governo, sem prejudicar a autonomia de tais entes? Para responder esses questionamentos, utilizou-se da pesquisa bibliográfica e do método hipotético-dedutivo, com o objetivo de verificar tal possibilidade, levando em consideração a legislação infraconstitucional e constitucional do ordenamento jurídico brasileiro
Determination of the electrical axis of the heart
Authors: Stafford Michael R. , Stafford Donald G. 
Published: October 2018

Abstract
The rapid, accurate determination of the electrical axis of a patient's heart is very useful for diagnosis. This determination can be made readily by using six electrocardiographic leads. The procedure for interpreting the data from these leads and determining the electrical axis of. the heart is charted. This method uses key leads I and a VF to determine the quadrant where the axis is located and secondary leads II, III, a VR, and a VL to find the axial position within the quadrant. When either I or a VF is isoelectric, only one key lead is used.
Correlative imaging of pelvic soft tissue sarcomas in children
Authors: Finkelstein Mark S. , Sherman Nancy H. , Rosenberg Henrietta Kotlus , Mahboubi Soroosh , Raney P. Beverly 
Published: October 2018

Abstract
The authors retrospectively reviewed 15 cases of pelvic soft tissue sarcoma treated at the Children's Hospital of Philadelphia during a recent 6-year period. These patients were treated before the availability of magnetic resonance imaging. The authors compared ultrasonography, computed tomography, and excretory urography/voiding cystourethrography for establishing the diagnosis and following the progression/regression of the disease. Results were correlated with clinical, surgical, and pathologic findings. Although computed tomography and ultrasonography were both capable of characterizing the size and texture of the lesion, computed tomography was superior in defining disease arising from the pelvic sidewall. Both techniques effectively identified residual mass at the tumor site, but neither could differentiate active tumor from inactive tumor, posttherapy inflammation, or fibrosis. Excretory urography/voiding cystourethrography provided no information that could not be gleaned from either ultrasonography or computed tomography.
Demonstration of Helicobacter pylori in tracheal secretions
Authors: Mitz Howard S. , Farber Steven S. 
Published: October 2018

Abstract
A new gram-negative bacterium, Helicobacter pylori, has been found in gastric secretions. In view of an almost 9% incidence of unidentified gram-negative bacteria in aspiration pneumonia, the authors set out to prove thatH pylori could be found in tracheal secretions. Eighteen sequential patients admitted to the intensive care unit who had endotracheal or nasogastric intubation for 24 hours or longer were studied. Of 20 sets of specimens from 18 patients, Helicobacter was recovered from 2 (10%) of the endotracheal specimens. The authors conclude that H pylori can gain access to the endobronchial tree and therefore may contribute to the origin of pneumonia due to unidentified gram-negative bacteria.
Delayed splenic rupture: An unusual cause of the acute surgical abdomen
Authors: Spencer David D. , Ragland Jerry J. 
Published: October 2018

Abstract
The diagnosis of delayed rupture of the spleen may be difficult to make because of the presumed triviality of the precipitating injury, an unpredictable time lag between the injury and the development of symptoms, and the possibility of atypical signs and symptoms remote from the bleeding spleen. The clinician may confuse the signs and symptoms with those of acute appendicitis or with some other cause. The authors present two case histories to illustrate the diagnostic difficulties caused by delayed rupture of the spleen. Whenever the acute surgical abdomen is present with concomitant anemia, the diagnosis of delayed rupture of the spleen should be considered.
Nephrology/hypertension/fluid and electrolyte disorders
Authors: Slick Gary L. 
Published: October 2018

Abstract
The following annotated bibliography has been developed for the purpose of providing to primary care physicians a handy source of review articles and major studies in the field of nephrology, hypertension, and fluid and electrolyte disorders. Almost all of the articles are review articles of clinical topics that would be of interest to the practicing physician. JAOA will be publishing additional annotated bibliographies in various fields of internal medicine over the next several months. This is the second in the series. Part 1 appeared in the January 1993 issue (93:50-65). Others will appear in forthcoming issues of THE JOURNAL.
Thoracic outlet syndrome-a myofascial variant: Part 3. Structural and postural considerations
Authors: Sucher Benjamin M. , Health Deborah M. 
Published: October 2018

Abstract
Thoracic outlet syndrome involves more than just local neurovascular compression. Myofascial release treatments and stretching exercises may be only partially or temporarily successful unless all related components of somatic dysfunction, including craniosacral mechanisms, are addressed. Structural and postural abnormalities in the frontal plane, as with a short leg, and in the sagittal plane, such as lumbopelvic imbalances, as well as neural involvement all contribute to thoracic outlet syndrome symptoms. Once segmental restrictions are treated and symptoms diminish, postural correction and strengthening exercises may be initiated. Osteopathic diagnosis and treatment of the local, regional, and remote structural problems is necessary for optimal treatment of thoracic outlet syndrome and the maintenance of a symptom-free status.
Flow cytometric determination of ploidy in prostatic adenocarcinoma and its relation to clinical outcome
Authors: Blatstein Lee M. , Ginsberg Philip C. , Daskal Ierachmiel , Finkelstein Leonard H. 
Published: October 2018

Abstract
Flow cytometry was used to measure the DNA content in paraffin-embedded archival specimens of prostatic adenocarcinoma. The specimens were from 49 patients who were found to have adenocarcinoma of the prostate at the time of transurethral resection of the prostate for bladder outlet obstruction. At initial presentation, 34 of these patients had clinically localized disease and 15 had metastatic disease. The authors studied the relationship of DNA ploidy to clinical stage, histologic grade, disease progression, and duration of survival. Their results indicate that regardless of the clinical stage at presentation, the mean time to disease progression is longer in a patient with a DNA diploid tumor when compared with that in a patient with a DNA aneuploid tumor (18.1 months vs 6.5 months, respectively). Additionally, mean time of survival was longer in a patient with a diploid tumor than in a patient with an aneuploid tumor (31.6 months vs 9.6 months, respectively).
Arranging affiliation agreements and outside rotations
Authors: Willard Ralph L. 
Published: October 2018

Abstract
Affiliation agreements are necessary when a sponsoring institution makes arrangements for all or part of the education elements of an internship or residency program to be delivered at another hospital. The sponsoring institution may be a college of osteopathic medicine or an osteopathic hospital. Some basic considerations, which are outlined herein, should be reviewed when the sponsoring institution enters such agreements. Some of these considerations are requirements of the American Osteopathic Association, while others are necessary to avoid later complications. Agreement should be reached on negotiable factors, accepted by both institutions, and then referred for legal review by appropriate authorities.
Cortical blindness and seizures possibly related to cisplatin, vinblastine, and bleomycin treatment of ovarian dysgerminoma
Authors: Young Donald C. , Mitchell Albert , Kessler John , Christman James Eric 
Published: October 2018

Abstract
Ovarian dysgerminoma is the most common ovarian malignancy in young women. Conservative treatment is indicated in the reproductive-age woman who wishes to preserve childbearing capacity. This case report describes a patient with ovarian dysgerminoma who underwent chemotherapy with a cisplatinvinblastine-bleomycin regimen that resulted in serious toxic complications-including cortical blindness and seizures that were transient in nature. Although current chemotherapy regimens have dramatically improved the overall survival of women with germ-cell tumors, there are toxic complications such as those demonstrated in this report, and toxicity must be balanced against presumed benefit.
Treatment of cutaneous T-cell lymphoma: An update
Authors: Young James W. 
Published: October 2018

Abstract
Cutaneous T-cell lymphoma is a malignancy of T cells that have an affinity for the skin. Prognosis and treatment depend on accurate staging using the TNM system. Treatment for stage I disease, which includes oral methoxsalen plus ultraviolet radiation (with or without retinoids), nitrogen mustard, total skin electron beam, and photopheresis, is generally helpful. Therapy for stage II, III, or IV disease is not as successful. Extracorporeal photopheresis is an exciting new treatment that perhaps offers help for certain cases of advanced disease. Despite current modes of treatment, cutaneous T-cell lymphoma frequently results in death.
Research secures the future of osteopathic medicine: Part 1. Research-foundation for faculty development, institutional recognition
Authors: Papa Frank J. 
Published: October 2018

Abstract
The first of a two-part feature examining the role of research in securing the future of osteopathic medicine, this article describes the historical development of research, specifically how it has come to symbolize valued intellectual and institutional markers in society. Administrators of colleges of osteopathic medicine are called on to increasingly support research-related activities to fully develop the intellectual potential of their faculty. Only through faculty development can osteopathic medical training institutions achieve their fullest potential and thereby secure a stable future for the profession.
Plasma concentrations of glutamate and its metabolites in patients with Alzheimer's disease
Authors: Schwartz Frederic N. , Miulli Dan E. , Norwell Doris Y. 
Published: October 2018

Abstract
Neurologic and psychologic tests without brain tissue biopsy do not establish the diagnosis of Alzheimer's disease. This pilot study demonstrates significant increases in the activity of plasma glutamate dehydrogenase and the plasma concentrations of aspartate, glutamate, and a-ketoglutarate in nursing home residents with previously diagnosed Alzheimer's disease when compared with that in other nursing home residents without Aldzheimer's disease who had no complicating conditions. Plasma concentrations of -y-aminobutyric acid, glutamine, and activities of plasma glutamate decarboxylase, glutaminase, and glutamine synthetase were not significantly different in the two groups. A discriminant analysis number, based on the four significantly different compounds, is obtained that may be used as the basis for an inexpensive, noninvasive, and accurate screening test for Alzheimer's disease.
Diagnosis and management of asthma: A brief review of two asthma expert panel reports
Authors: D’Alonzo Gilbert E. , Krachman Samuel L. 
Published: October 2018

Abstract
During the past decade, asthma morbidity and mortality have increased noticeably. Although the reasons for the increase are not clear, the prevalence of asthma has been reported to be increasing not only in the United States but also in other countries throughout the world, including the United Kingdom, New Zealand, and Australia. Asthma mortality rates and morbidity trends are increasing despite what appears to be major scientific advances in our understanding of asthma and in the face of a multitude of new therapeutic modalities. This article presents a brief overview of the pathogenesis and diagnosis of asthma, and highlights the major management recommendations of two expert panel reports.
Unexpected adverse effects of Freon 11 and Freon 12 as medication propellants
Authors: Oenbrink Raymond J. 
Published: October 2018

Abstract
Metered-dose inhalers are frequently used in treating pulmonary diseases associated with bronchoconstriction, chiefly asthma and chronic bronchitis. These aerosolized medications are not without the potential for adverse effects. The author describes two patients who likely had adverse reactions to the Freon propellants used in the inhalers. These reactions are reported in order to alert physicians to their possible occurrence and to suggest a rational treatment approach.
Tennis elbow: A biomechanical and therapeutic approach
Authors: Steiner Charles , Schnatz Peter 
Published: October 2018

Abstract
Lateral epicondylitis, one of the most common lesions of the arm, affects some 50% of tennis players. This condition poses a problem in clinical management because treatment is dependent not only on proper medical therapy but also on correction of the improper on-court biomechanics. The most common flaw is a late contact on the backhand groundstroke, forcing the player to extend the wrist with the extensor muscles. This action predisposes to trauma of the tendon fibers at the lateral epicondyle. Understanding the biomechanics will better prepare the physician to advise the patient and to communicate with a tennis teaching professional to facilitate long-term relief.
Comparison of thoracic manipulation with incentive spirometry in preventing postoperative atelectasis
Authors: Kelso Albert F. , Sleszynski Sandra L. 
Published: October 2018

Abstract
Atelectasis is a preventable complication that often occurs after upper abdominal surgery. In our I-year randomized, researcher-blinded trial, low-risk cholecystectomy patients were subjected to either the thoracic lymphatic pump (n=21) or incentive spirometry (n=21) to prevent atelectasis. The treatment groups were equal with respect to risk factors for atelectasis and deviation of preoperative respiratory parameters (forced vital capacity [FVC] and forced expiratory volume in one second [FEVI ]) from the predicted values. Atelectasis occurred in 2 (5%) of 21 patients regardless of whether incentive spirometry or thoracic lymphatic pump treatment was used. Study patients treated with the thoracic lymphatic pump technique had an earlier recovery and quicker return toward preoperative values for FVC and FEVI than patients treated with incentive spirometry.
Pathophysiological basis of low contrast visual acuity loss in multiple sclerosis
Authors: Triplett James D. , Yiannikas Con , Barnett Michael H. , Parratt John , Barton Joshua , Graham Stuart L. , You Yuyi , Klistorner Alexander 
Published: October 2018

AbstractObjectiveThere is currently an urgent need for reliable clinical biomarkers of remyelination to be used in Phase 2 and Phase 3 clinical trials. Low contrast visual acuity (LCVA) has been suggested as a functional measure of the integrity of the visual pathway. Therefore, the aim of this study was to elucidate the potential contribution of axonal loss and demyelination toLCVAloss inMSpatients.MethodIn this study, 50 consecutive relapsing remittingMSpatients with a previous history of unilateral optic neuritis were enrolled. Using the linear regression model, we assessed the relative contribution of multifocal Visual Evoked Potentials (mfVEP) latency and Retinal Nerve Fiber Layer (RNFL) thickness toLCVAdeficit.ResultsIntereye asymmetry of mfVEPlatency andRNFLthickness correlated significantly with intereye asymmetry ofLCVA(P < 0.001). A linear regression model demonstrated increased predictive power ofLCVAwhen mfVEPlatency andRNFLthinning were combined (reachingR2 = 0.67) and confirmed a higher predictive value ofRNFLthinning compared to mfVEPlatency delay for both contrast levels. However, elimination of subjects with severe axonal loss dramatically increased the relative contribution of mfVEPlatency, with contribution ofRNFLthickness losing significance for both 1.25% and 2.5%LCVA.InterpretationWhile retinal ganglion cell axonal loss is a superior predictor ofLCVA, the degree of demyelination contributes significantly to worsening ofLCVA, particularly when patients with severe axonal loss are excluded. These results support the feasibility of usingLCVAas a functional biomarker in remyelination therapy trials, providing appropriate patient's selection criteria are implemented.
PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome
Authors: Alkhater Reem A. , Scherer Stephen W. , Minassian Berge A. , Walker Susan 
Published: October 2018

AbstractWe report a family of Saudi Arabian ancestry with two children presenting with global developmental delay, dystonia, disturbed sleep, and heat intolerance. By genome sequencing, we identified a nonsense variant in the first exon of PI4K2A that was homozygous in both affected individuals and was absent from, or heterozygous in, seven unaffected siblings. PI4K2A is highly expressed in the brain and a mouse model displays a neurological phenotype, implicating PI4K2A as a new disease gene for a neurological disorder.
Programmable Chemotherapy and Immunotherapy against Breast Cancer Guided by Multiplexed Fluorescence Imaging in the Second Near‐Infrared Window
Authors: Hao Xiaoxia , Li Chunyan , Zhang Yejun , Wang Haozhi , Chen Guangcun , Wang Mao , Wang Qiangbin 
Published: October 2018

AbstractCombined chemotherapy and immunotherapy have demonstrated great potential in cancer treatment. However, it is difficult to provide clear information of the pharmacokinetics and pharmacodynamics of chemodrugs and transplanted immune cells in vivo by traditional approaches, resulting in inadequate therapy. Here, a multiplexed intravital imaging strategy by using fluorescence in the second near‐infrared window (NIR‐II) is first developed to visualize the two events of chemotherapy and immunotherapy in vivo, so that a combinational administration is programed to improve the therapeutical effects against a mouse model of human breast cancer. In detail, Ag2Se quantum dots (QDs) (λEm = 1350 nm) loaded with stromal‐cell‐derived factor‐1α (SDF‐1α) and chemodrug doxorubicin (DOX) are first administrated to deliver the SDF‐1α and DOX to the tumor site. After their arrival, monitored by Ag2Se QD fluorescence, natural killer (NK)‐92 cells labeled with Ag2S QDs (λEm = 1050 nm) are intravenously injected so that the cells are recruited to the tumor by the chemotaxis of SDF‐1α, which is visualized by Ag2S QD fluorescence. Such an imaging approach allows simultaneous evaluation of the behaviors of individual injections in vivo, and facilitates optimized administration regimens, resulting in enhanced tumor inhibition.