bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone H1 improves regeneration after mouse spinal cord injury and changes shape and gene expression of cultured astrocytes
Authors: Kleene Ralf , Loers Gabriele , Jakovcevski Igor , Mishra Bibhudatta , Schachner Melitta 
Published: June 2019

Background: We have shown that histone H1 is a binding partner for polysialic acid (PSA) and that it improves functional recovery, axon regrowth/sprouting, and target reinnervation after mouse femoral nerve injury. Objective: Here, we analyzed whether histone H1 affects functional recovery, axon regrowth/sprouting, and target reinnervation after spinal cord injury of adult mice. Furthermore, we tested in vitro histone H1’s effect on astrocytic gene expression, cell shape and migration as well as on cell survival of cultured motoneurons. Methods: We applied histone H1 to compressed spinal cord and determined functional recovery and number of fibrillary acidic protein (GFAP)- and neuron-glial antigen 2 (NG2)- positive glial cells, which contribute to glial scarring. Histone H1’s effect on migration of astrocytes, astrocytic gene expression and motoneuronal survival was determined using scratch-wounded astroglial monolayer cultures, astrocyte cultures for microarray analysis, and motoneuron cell culture under oxidative stress conditions, respectively. Results: Histone H1 application improves locomotor functions and enhances monoaminergic and cholinergic reinnervation of the spinal cord. Expression levels of GFAP and NG2 around the lesion site were decreased in histone H1-treated mice relative to vehicle-treated mice six weeks after injury. Histone H1 reduced astrocytic migration, changed the shape of GFAP- and NG2-positive glial cells and altered gene expression. Gene ontology enrichment analysis indicated that in particular genes coding for proteins involved in proliferation, differentiation, migration and apoptosis are dysregulated. The up- and down-regulation of distinct genes was confirmed by qPCR and Western blot analysis. Moreover, histone H1 reduced hydrogen peroxide-induced cell death of cultured motoneurons. Conclusions: The combined observations indicate that histone H1 locally applied to the lesion site, improves regeneration after spinal cord injury. Some of these beneficial functions of histone H1 in vivo and in vitro can be attributed to its interaction with PSA-carrying neural cell adhesion molecule.
The effects of five sessions of continuous theta burst stimulation over contralesional sensorimotor cortex paired with paretic skilled motor practice in people with chronic stroke
Authors: Neva J.L. , Brown K.E. , Wadden K.P. , Mang C.S. , Borich M.R. , Meehan S.K. , Boyd L.A. 
Published: June 2019

Background: In individuals with chronic stroke, impairment of the paretic arm may be exacerbated by increased contralesional transcallosal inhibition (TCI). Continuous theta burst stimulation (cTBS) can decrease primary motor cortex (M1) excitability and TCI. However, contralesional cTBS shows inconsistent effects after stroke. Variable effects of cTBS could stem from failure to pair stimulation with skilled motor practice or a focus of applying cTBS over M1. Objective: Here, we investigated the effects of pairing cTBS with skilled practice on motor learning and arm function. We considered the differential effects of stimulation over two different brain regions: contralesional M1 (M1c) or contralesional primary somatosensory cortex (S1c). Methods: 37 individuals with chronic stroke participated in five sessions of cTBS and paretic arm skilled practice of a serial targeting task (STT); participants received either cTBS over M1c or S1c or sham before STT practice. Changes in STT performance and Wolf Motor Function Test (WMFT) were assessed as primary outcomes. Assessment of bilateral corticospinal, intracortical excitability and TCI were secondary outcomes. Results: cTBS over sensorimotor cortex did not improve STT performance and paretic WMFT-rate beyond sham cTBS. TCI was reduced bi-directionally following the intervention, regardless of stimulation group. In addition, we observed an association between STT performance change and paretic WMFT-rate change in the M1c stimulation group only. Conclusions: Multiple sessions of STT practice can improve paretic arm function and decrease TCI bilaterally, with no additional benefit of prior cTBS. Our results suggest that improvement in STT practice following M1c cTBS scaled with change in paretic arm function in some individuals. Our results highlight the need for a better understanding of the mechanisms of cTBS to effectively identify who may benefit from this form of brain stimulation.
Wide-detector CT combined iterative reconstruction in pediatric low-dose scan of the paranasal sinus
Authors: Kong Que , Lu Fengqi , Gao Yu , Qiao Peng , Shao Min , Xie Min 
Published: June 2019

BACKGROUND: Computed tomography (CT) is considered a standard modality for imaging the paranasal sinus (PS), but increasingly radiation dose is of concern, especially in children. Objective: This study aims to investigate the feasibility of using a 320-detector CT scanner with a 16 cm wide-detector combined with iterative reconstruction (IR) algorithm to further reduce radiation dose when scanning the PS. METHODS: A total of 90 children who underwent CT of the PS were randomly allocated into three groups namely, (1) the experimental group using low-dose wide-detector scan ( n = 30, 9±4 years); (2) low-dose helical group ( n = 30, 9±4 years); and (3) pediatric conventional group ( n = 30, 8±4 years). Statistical software SPSS 19.0 was used for one-way ANOVA analysis of the general data (age, BMI), image quality, and radiation dose. Multiple comparisons of data without homogeneity of variance were analyzed by Bonferroni test and Tamhane’s test. RESULTS: All patients underwent successful CT examinations. No significant differences in the general data and image quality evaluation were detected between three groups (all P values > 0.05). CTDIvol and DLP were 2.87 mGy and 32.58 mGy·cm in the experimental group, 4.92 mGy and 70.84 mGy·cm in the low-dose helical group, and 9.95 mGy and 131.83 mGy·cm in the conventional group, respectively, which were significantly different among these three groups as indicated by multiple comparisons (all P values < 0.05). In the experimental group, the effective radiation dose was 0.07 mSv, which was reduced by 76% and 56% comparing to the conventional group and the low-dose helical group, respectively. CONCLUSIONS: The 320-detector CT scanner equipped with the wide-detector combined with IR can further reduce radiation dose, while maintaining good image quality comparing to the low-dose helical or pediatric modes.
Deep CNN models for pulmonary nodule classification: Model modification, model integration, and transfer learning
Authors: Zhao Xinzhuo , Qi Shouliang , Zhang Baihua , Ma He , Qian Wei , Yao Yudong , Sun Jianjun 
Published: June 2019

BACKGROUND: Deep learning has made spectacular achievements in analysing natural images, but it faces challenges for medical applications partly due to inadequate images. OBJECTIVE: Aiming to classify malignant and benign pulmonary nodules using CT images, we explore different strategies to utilize the state-of-the-art deep convolutional neural networks (CNN). METHODS: Experiments are conducted using the Lung Image Database Consortium image collection (LIDC-IDRI), which is a public database containing 1018 cases. Three strategies are implemented including to 1) modify some state-of-the-art CNN architectures, 2) integrate different CNNs and 3) adopt transfer learning. Totally, 11 deep CNN models are compared using the same dataset. RESULTS: Study demonstrates that, for the model modification scheme, a concise CifarNet performs better than the other modified CNNs with more complex architectures, achieving an area under ROC curve of AUC = 0.90. Integrated CNN models do not significantly improve the classification performance, but the model complexity is reduced. Transfer learning outperforms the other two schemes and ResNet with fine-tuning leads to the best performance with an AUC = 0.94, as well as the sensitivity of 91% and an overall accuracy of 88%. CONCLUSIONS: Model modification, model integration, and transfer learning can play important roles to identify and generate optimal deep CNN models in classifying pulmonary nodules based on CT images efficiently. Transfer learning is preferred when applying deep learning to medical imaging applications.
PEMANFAATAN PERANGKAT TIK BANTUAN USO UNTUK PEMBELAJARAN DI SMPN 2 SAKRA, KABUPATEN LOMBOK TIMUR
Authors: Supandri Supandri - , Siahaan Sudirman 
Published: June 2019

Universal Service Obligation (USO) merupakan program gratis penyedia jasa berbasis WiFi dari pemerintah pusat sebagai ruang pelayanan publik untuk teknologi internet (interconnection networking). Program ini merupakan program kerja sama antara Kementerian Komunikasi dan Informatika (Kemkominfo) dengan Kementerian Pendidikan dan Kebudayaan (Kemendikbud). Tujuannya adalah memfasilitasi sekolah-sekolah di daerah terdepan, terpencil, dan tertinggal (3T) agar dapat memanfaatkan perangkat Teknologi Informasi dan Komunikasi (TIK) dan sarana pendukungnya untuk kepentingan pembelajaran dan komunikasi. Guru dan peserta didik diharapkan dapat memanfaatkannya seoptimal mungkin untuk mengakses konten pembelajaran melalui berbagai sumber sehingga kegiatan pembelajaran menjadi menarik dan sekaligus menantang. Tulisan ini merupakan studi kasus yang dilaksanakan di SMPN 2 Sakra, Kabupaten Lombok Timur, Provinsi Nusa Tenggara Barat. Fokus penelitian ini adalah mengenai sejauh mana pemanfaatan fasilitas TIK bantuan USO untuk pembelajaran,baik yang berkaitan dengan pelaksanaan, dampak, tantangan, dan peluang pengembangannya.Tujuannya adalah untuk mengetahui sejauh mana perangat TIK bantuan USO sudah dimanfaatkan untuk pembelajaran. Metoda yang digunakan untuk mendapatkan data dan informasi adalah wawancara, observasi (pengamatan), dan dokumentasi. Data dan informasi yang telah dikumpulkan, dikelompokkan untuk dianalisis dan disajikan secara deskriptif. Hasil penelitian mengungkapkan bahwa belum semua guru dan peserta didik memanfaatkan perangkat TIK bantuan USO yang tersedia di sekolah untuk pembelajaran.Â Universal Service Obligation (USO) is a Free Wifi Service Program from the central government for the public (interconnection networking). This is a collaborative program between the Ministry of Communication and Informatics and the Ministry of Education and Culture. The objective of the program is to facilitate schools in the frontier, remote, and left areas in utilizing ICT and supporting infrastructures for the necessity of learning and communication purposes. It is hoped that teachers and students can optimally utilize it in accessing the learning contents so that the learning activities become interesting as well as triggering. This article is a case study conducted in SMPN 2 Sakra, Lombok Timur District, Nusa Tenggara Barat Province. The focus of this study is the utilization of USO-ICT equipment for learning, related to the conduct, impact, challenges,and its development possibility. The objective of this study is to know how far the USO-ICT equipment and its facility has been utilized for learning. The data and information is collected through interview, observation,and documentation. Then, the gathered data and information is grouped to be analyzed and presented descriptively. The result shows that not all teachers and students have already utilized the available USO-ICT equipment for learning.
MODEL PEMBELAJARAN INVESTIGASI KELOMPOK UNTUK MENGANALISIS BENTANG ALAM HASIL GAYA GEOLOGI MELALUI PENGGUNAAN GOOGLE EARTH
Authors: Oktavianto Dwi Angga 
Published: June 2019

Penelitian ini bertujuan untuk meningkatkan keterampilan berpikir kritis siswa agar dapat melakukan analisis terhadap bentang alam hasil dari gaya geologi. Tindakan yang dilakukan ialah dengan memanfaatkan Google Earth melalui model pembelajaran Investigasi Kelompok. Penelitian ini menggunakan metode penelitian tindakan kelas. Penelitian dilakukan pada kelas X Geology Pertambangan SMK Negeri 1 Binuang dengan jumlah subjek 33 siswa. Data hasil penelitian pada siklus-2 menunjukkan adanya peningkatan kemampuan beprikir kritis dibandingkan dengan siklus-1 dmanasiswa dengan tingkat berpikir (1) kurang kritis, dari yang semula 70% menjadi 12%; (2) cukup kritis, dari 15% menjadi 33%; (3) berpikir kritis, dari 15% menjadi 46%; dan (4) berpikir sangat kritis, dari yang semula tidak ada menjadi 9%.Â Â This study aims to improve students' critical thinking skills so that they can conduct an analysis of the landscape resulting from geological forces. The action taken is to utilize Google Earth through the Group Investigation learning model.This research uses classroom action research methods. The study was conducted in class X Mining Geology of SMK Negeri 1 Binuang with a total of 33 student subjects. The data show thatfrom cycle-2 indicates an increasein studentsâ€™ order thinking skills,whichare: 1) less critical, from 70% to 12%; 2) quitecritical, from 15% to 33%; 3) critical, from 15% to 46%; and 4) highly critical, from 0 to 9%.
BENTUK ESTETIK ONDEL-ONDEL
Authors: Supriyanto S., , Dharsono D., 
Published: June 2019

<p><span>Studi tentang keberadaan <span><em>Ondel-ondel </em><span>di Jakarta sebagai sajian dan fungsi Ondel-ondel. Penelitian ini <span>menjelaskan bentuk dan pemaknaan <span><em>Ondel-ondel </em><span>dikaji dengan pendekatan estetik digunakan teori De Witt H. <span>Parker. Pembahas masalah tersebut menggunakan metode penelitian kualitatif. Analisis data menggunakan <span>interaksi analisis dan interprestasi analisis tekstual. Keberadaan <span><em>Ondel-ondel </em><span>di Jakarta berdasarkan dari latar <span>belakang sejarah <span><em>Ondel-ondel </em><span>sebelumnya bernama Barongan setelah mendapatkan kembang kelapa (<span><em>ronceronce</em><span>) yang terbuat dari kertas nama Barongan diganti dengan Ondel-ondel. Barongan di yakini masyarakat <span>Betawi memiliki kekuatan magis berkarakter seram berfungsi sebagai penolak mara bahaya (sedekah desa<br /><span>atau sedekah bumi) dan peresmian gedung pada masa lalu. Tetapi sekarang <span><em>Ondel-ondel </em><span>dengan bentuknya <span>yang ramah berfungsi sebagai hiburan seremonial dan dekorasi untuk tujuan estetis.<br /><span><strong>Kata kunci: </strong><span>Ondel-Ondel, Estetik.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p><p><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><em>It is a study on the existence of </em><span>Ondel-ondel <span><em>in Jakarta as an entertainment and a function of </em><span>Ondel-ondel. <span><em>This research tells about the form and meaning of </em><span>Ondel-ondel<span><em>. It is analyzed through aesthetic approach of </em><span><em>De Witt H. Parker’s theory and uses qualitative method. Data is analyzed by using interaction analysis and </em><span><em>textual analysis interpretation. Based on the historical background of </em><span>Ondel-ondel<span><em>, it is previously named </em><span><em>Barongan and after getting coconut flower </em><span>(ronce-ronce<span><em>) made of paper, it is changed to </em><span>Ondel-ondel<span><em>.People in</em><br /><span><em>Betawi believe that Barongan has a magic power with scary character functioning to avoid danger (</em><span>offerings to <span>village or earth)<span><em>) and building inauguration in the past. But nowadays,</em><span>Ondel-ondel <span><em>with a kindly form becomes</em><br /><span><em>a ceremonial entertainment and decorations for aesthetic meaning.</em><br /><span><strong><em>Keywords: </em></strong><span><em>Ondel-ondel, Aesthetic.</em></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p>
ESTETIKA SENI LUKIS KARYA KOEBOE SARAWAN
Authors: Yulianto Y , Kartika Dharsono Sony 
Published: June 2019

<p>Tulisan ini merupakan bagian dari karya tesis Yulianto, 2017, dengan judul “Seni Lukis karya Koeboe Sarawan, Kritik Seni Holistik.” Keberadaan seni lukis karya Koeboe Sarawan dalam kancah seni rupa modern Indonesia, dipahami sebagai karya seni yang memiliki karakteristik tersendiri. Eksistensi dan konsistensi Koeboe dalam melahirkan karya-karya diyakini tidak lepas dari sebuah proses kreatif, telah melatar belakangi perumusan masalah tulisan ini: 1) Bagaimana proses penciptaan seni lukis Koeboe Sarawan?; 2) Bagaimana bentuk estetis seni lukis karya Koeboe Sarawan?. Penelitan ini merupakan sebuah penelitian kualitatif, dengan menggunakan pendekatan kreativitas. Metode dalam penelitian ini, yakni deskriptif analisis dan didukung analisis interpretatif. Temuan dalam penelitian ini adalah karya seni lukis Koeboe Sarawan merupakan bentuk aktualisasi diri seniman (Koeboe Sarawan) dalam memahami perjalanan dan arti kehidupan sejati. Karya-karya seni lukis karya Koeboe Sarawan telah menghadirkan nilai-nilai estetika; kesatuan, kompleksitas, dan intensitas.<br />Kata kunci: konsep penciptaan, kreativitas, dan estetika.</p><p> </p><p>This paper is part of Yulianto’s thesis work, 2017, with the title “Seni Lukis Karya Koeboe Sarawan, Kritik Seni Holistik.” The existence of Koeboe Sarawan’s art of painting in the Indonesian modern art scene is understood as an artwork that has its own characteristics. Koeboe’s existence and consistency in giving birth to the works is believed to be inseparable from a creative process, has been the background of the formulation of this writing problem: 1) What is the process of Koeboe Sarawan’s painting art creation ?; 2) What is the aesthetic form of painting by Koeboe Sarawan? This research is a qualitative research, using a creative approach. The method in this study, which is descriptive analysis and supported by interpretive analysis. The findings in this study are that Koeboe Sarawan’s painting is a form of self-actualization of the artist (Koeboe Sarawan) in understanding the journey and meaning of true life. The works of painting by Koeboe Sarawan have presented aesthetic values; unity, complexity, and intensity.<br />Keywords: creation, creativity, and aesthetic concepts.</p>
ESTETIKA WANGSALAN DALAM LAGU SINDHENAN KARAWITAN JAWA
Authors: Rahayu Sukesi 
Published: June 2019

<p align="center"><strong>ABSTRAK</strong></p><p> </p><p>Sindhenan merupakan salah satu aspek penting dalam pergelaran Karawitan Jawa baik dalam pertunjukan mandiri maupun fungsi karawitan sebagai salah satu pendukung pertunjukan yang memiliki unsur-unsur estetis maupun etis. Unsur-unsur estetis berkaitan dengan bentuk susunan frasa serta diksi yang digunakan dalam teks sindhenan, antara lain yang terdapat dalam wangsalan. Wangsalan merupakan salah satu teks sindhenan yang memiliki kandungan nilai yang dihayati dan diyakini sebagai pandangan hidup masyarakat jawa, nilai-nilai tersebut selanjutnya disebut sebagai nilai etis yang terbingkai dalam budaya jawa. Penelitian ini merupakan penelitian yang mengkaji makna yang terkandung dalam wangsalan sindhenan yang dikaji dengan perspekstif estetika bunyi dan persajakan. Metode yang digunakan dalam penelitian ini merupakan model penelitian kualitatif dimana data yang disajikan merupaka data yang diperoleh secara langsung dari lapangan, dengan sudut pandang penulis sebagai pelaku. Hasil dari penelitian ini mengungkap makna yang terkandung dalam wangsalan yang disampaikan oleh seorang sindhen hubunganya dengan ideologi serta cara pandang orang jawa dalam memaknai kehidupan.</p><p> </p><p><strong>Kata kunci: </strong>Sindhen, Wangsalan, Estetika Bunyi.</p><p> </p><p> </p><p align="center"><strong><em>ABSTRACT</em></strong></p><p> </p><p><em>Sindhenan is an important aspect in the performance of Javanese Karawitan both in independent perfor-mances and karawitan functions as one of the supporting aspects of the performance that has aesthetic and ethical elements. Aesthetic elements are related to the form of the phrase structure and the diction used in the sindhenan text, including those in the </em>wangsalan<em>. </em>Wangsalan<em> is one of the sindhenan texts which has values that are appreciated and believed to be a Javanese view of life. These values are then referred to as ethical values framed in Javanese culture. This research studies the meaning contained in the sindhenan wangsalan which is studied with aesthetic perspectives of sound and poetry. The method used in this study is a qualitative research model where the data presented is data obtained directly from the field, with the author’s perspective as the actor. The results of this study reveal the meaning contained in wangsalan conveyed by a sindhen in relation to the Javanese view and ideology in interpreting life.</em></p><p> </p><p><strong><em>Keywords: </em></strong><em>Sindhen, Wangsalan, Sound Aesthetics.</em></p>
Modelling and Model-Based Control of an HVAC System
Authors: Kardos Tamás , Kutasi Dénes Nimród 
Published: June 2019

Abstract
An HVAC system contains heating, ventilation and air conditioning equipment used in office or industrial buildings. The goal of this research is to design a controller for the process of cooling an office building that is made up of three rooms. The desired room temperature can be achieved by controlling the fans making up the fan coil units and the cooling medium’s temperature. By these means the building connected to the electrical grid becomes a smart office. The used building model includes several dynamically changing interior and exterior heat sources affecting the inner climate, which introduces a level of uncertain prediction into the system. We have determined the controller’s performance by the rate of deviation from the expected temperature, the consumed electrical energy and the generated noise. The controller was created in Matlab Simulink with the possibility of migration to a Siemens PLC.
Applicability Investigation of Joining Technologies for Diamond Core Bits
Authors: Kenéz Attila Zsolt , Bagyinszki Gyula 
Published: June 2019

Abstract
For the joining of two metallic components of different material quality, different methods of welding or soldering techniques are used. In this case, these two material qualities are given by the segments containing diamond particles, and thin-walled steel tube. In our previous paper we analysed welded joints with two different kinds of laser sources. In this paper we extend the previous investigations with the analysis of capacitor discharge welded and flame soldered samples. We examine the microstructure of the joints and record the chemical element maps to determine if alloying was formed. Joints are also subjected to fracture and hardness testing. This investigation shows that the applied joining technology meets the increased technical requirements because the joining zone must bear high mechanical and significant thermal loads during usage.