bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origin of Overpressure and Its Influence on Hydrocarbon Leakage in Mosuowan Uplift of the Junggar Basin, NW China
Authors: Ding Xiujian , You Guojian , Yiming Ablimit , Liu Hailei , Jiang Wenlong , Cao Zhe , Zha Ming , Qu Jiangxiu 
Published: November 2024

ABSTRACTThe Junggar Basin is one of the main petroliferous basins in Western China. The Mosuowan Uplift, located in the central part of the Junggar Basin, is a favourable hydrocarbon accumulation zone. The overpressure is widely developed in the strata below the Jurassic, and the pressure coefficient gradually increases with the buried depth, up to 2.15. Based on the multi‐logging combination method, Bowers method, sonic velocity–density cross‐plot method and combined with geological setting, using porosity data of sandstone, geochemical data of source rocks, acoustic transit time ‐resistivity cross plots and so on, the origins of overpressure in each stratum of the Mosuowan Uplift are analysed. The results show that disequilibrium compaction, pressure transfer and tectonic compression are the main reasons for the development of deep overpressure. Disequilibrium compaction is considered to be an important reason for overpressure in Jurassic, Triassic, Upper Permian Upper Wuerhe Formation and Middle Permian Lower Wuerhe Formation due to the development of multiple sets of mudstone in deep strata. The Jurassic is charged by deep overpressure fluid, and the pressure transfer also has a significant contribution to the overpressure of Jurassic. The tectonic inversion occurred in the central part of the basin at the end of the Early Permian, and the overpressure in the Middle Permian Xiazijie Formation was closely related to tectonic compression. The hydrocarbon generation of the Permian and Jurassic source rocks has little contribution to the overpressure of the Mosuowan Uplift due to the poor source rock. The Mosuowan Uplift is an inherited anticline, adjacent to hydrocarbon generation sag, which is the dominant direction of oil and gas migration, but drilling confirmed that the deep reservoir is water layer. Comprehensive analysis of maturity parameters, logging fluorescence show and quantitative fluorescence analysis indicates that overpressure caused oil and gas leakage and destroyed hydrocarbon reservoirs.
Exposure of Porcine Oocytes to Methylparaben During In Vitro Maturation Alters the Expression of Genes Involved in Cumulus Cell Expansion and Steroidogenesis, Decreasing Hyaluronic Acid and Progesterone Synthesis
Authors: Barajas‐Salinas Adyeni , Bahena Iván , Rodríguez‐Mercado Juan José , Juárez‐Rojas Lizbeth , Betancourt Miguel , Núñez‐Macías Elivier , Ramírez‐Jara Yenny , López Alma , Casas Eduardo , Bonilla Edmundo , Salazar Zayil , Casillas Fahiel 
Published: November 2024

ABSTRACTParabens are widely used because of their antimicrobial properties in drugs, cosmetics, and food; however, it has been reported that methylparaben may adversely influence female reproduction. Methylparaben decreases oocyte in vitro maturation at a maturation inhibition concentration 50 of 780.31 μM but also decreases oocyte viability at a lethal concentration 50 of 2028.38 μM. Additionally, parabens are endocrine disruptors, affecting steroidogenesis as well as cumulus cell expansion. Therefore, the aim of this study was to elucidate some of the mechanisms by which methylparaben alters cumulus cell expansion and decreases oocyte maturation through the evaluation of gene expression related to cumulus cell expansion, hyaluronic acid, and progesterone synthesis. For this, oocytes were exposed to different methylparaben concentrations of 0 (control), 650, 780, and 1000 μM for 20 and 44 h of in vitro maturation. The cumulus cell expansion rates, maturation rates, gene expression rates, and hyaluronic acid and progesterone concentrations were revaluated after 20 and 44 h of culture. At sublethal concentrations, methylparaben decreased in vitro maturation as well as cumulus cell expansion at 44 h. Additionally, methylparaben decreased the expression of Has2 and Cd44 at 20 and 44 h of maturation. The expression levels of Stard1, Cyp11a1, and Hsd3b1 were also altered by methylparaben exposure at 20 and 44 h of maturation, suggesting its role as an endocrine disruptor. Hyaluronic acid and progesterone concentrations in the culture medium decreased at 20 and 44 h. These findings could partially explain some of the mechanisms by which methylparaben alters female fertility.
IFN‐α treatment may enable discontinuation of TKIs in NK cell‐licensed patients with CML‐CP
Authors: Ureshino Hiroshi , Kamachi Kazuharu , Kidoguchi Keisuke , Kimura Shinya 
Published: November 2024

AbstractThe magnitude of the natural killer (NK) cell response contributes to the achievement of treatment‐free remission (TFR) in patients with chronic myeloid leukemia (CML) and is regulated by the interaction between killer immunoglobulin‐like receptors (KIRs) on NK cells and human leukocyte antigen (HLA) class I molecules on target cells. The abundant combination between KIR and HLA through genetic polymorphisms determines the functional diversity of NK cells. We previously reported that KIR3DL1‐HLA‐Bw status is associated with achievement of TFR by reflecting NK cell potential. Patients with strong interaction between KIR3DL1/HLA‐Bw were identified as having a higher molecular relapse risk, based on the “missing self” hypothesis which suggests that the lack of cognate ligands for KIRs may induce target cell lysis. However, all the patients with strong interaction between KIR3DL1/HLA‐Bw who received prior IFN‐α therapy achieved TFR (p = 0.007), explained by the “NK cell licensing” concept, whereby NK cells become more functional through the recognition “self” HLA class I molecules by KIRs. NK cell licensing may contribute to the potential efficacy of IFN‐α treatment in patients with CML. We defined high‐risk molecular relapse patients and suggest that KIR3DL1/HLA‐Bw status may help detect patients who could benefit from IFN‐α for maintaining TFR.
Estimated Brain Age in Healthy Aging and Across Multiple Neurological Disorders
Authors: Chai Li , Sun Jun , Zhuo Zhizheng , Wei Ren , Xu Xiaolu , Duan Yunyun , Tian Decai , Bai Yutong , Zhang Ningnannan , Li Haiqing , Li Yuxin , Li Yongmei , Zhou Fuqing , Xu Jun , Cole James H. , Barkhof Frederik , Zhang Jianguo , Zheng Huaguang , Liu Yaou 
Published: November 2024

BackgroundThe brain aging in the general population and patients with neurological disorders is not well understood.PurposeTo characterize brain aging in the above conditions and its clinical relevance.Study TypeRetrospective.PopulationA total of 2913 healthy controls (HC), with 1395 females; 331 multiple sclerosis (MS); 189 neuromyelitis optica spectrum disorder (NMOSD); 239 Alzheimer's disease (AD); 244 Parkinson's disease (PD); and 338 cerebral small vessel disease (cSVD).Field Strength/Sequence3.0 T/Three‐dimensional (3D) T1‐weighted images.AssessmentThe brain age was estimated by our previously developed model, using a 3D convolutional neural network trained on 9794 3D T1‐weighted images of healthy individuals. Brain age gap (BAG), the difference between chronological age and estimated brain age, was calculated to represent accelerated and resilient brain conditions. We compared MRI metrics between individuals with accelerated (BAG ≥ 5 years) and resilient brain age (BAG ≤ −5 years) in HC, and correlated BAG with MRI metrics, and cognitive and physical measures across neurological disorders.Statistical TestsStudent's t test, Wilcoxon test, chi‐square test or Fisher's exact test, and correlation analysis. P < 0.05 was considered statistically significant.ResultsIn HC, individuals with accelerated brain age exhibited significantly higher white matter hyperintensity (WMH) and lower regional brain volumes than those with resilient brain age. BAG was significantly higher in MS (10.30 ± 12.6 years), NMOSD (2.96 ± 7.8 years), AD (6.50 ± 6.6 years), PD (4.24 ± 4.8 years), and cSVD (3.24 ± 5.9 years) compared to HC. Increased BAG was significantly associated with regional brain atrophy, WMH burden, and cognitive impairment across neurological disorders. Increased BAG was significantly correlated with physical disability in MS (r = 0.17).Data ConclusionHealthy individuals with accelerated brain age show high WMH burden and regional volume reduction. Neurological disorders exhibit distinct accelerated brain aging, correlated with impaired cognitive and physical function.Level of Evidence4Technical EfficacyStage 2
Epidemiological Surveillance and Genomic Characterization of Soochong Virus From Apodemus Species Using Multiplex PCR‐Based Next‐Generation Sequencing, Republic of Korea
Authors: Park Kyungmin , No Jin Sun , Prayitno Sara P. , Seo Ye‐rin , Lee Seung‐Ho , Noh Juyoung , Kim Jongwoo , Kim Seong‐Gyu , Cho Hee‐Kyung , Natasha Augustine , Kim Bohyeon , Park Jieun , Kim Won‐Keun , Song Jin‐Won 
Published: November 2024

ABSTRACTOrthohantavirus hantanense causes hemorrhagic fever with renal syndrome in Eurasia, posing a substantial public health threat. Although the Hantaan virus is the primary etiological agent in the Republic of Korea (ROK), evidence suggests the potential zoonotic transmission of the Amur virus (AMRV), closely related to the Soochong virus (SOOV), to humans in China and Russia. This study examined 31 Apodemus spp. captured from six regions in Gangwon Province, ROK, between 2015 and 2018. Of these, 5/31 (16.1%) tested positive for anti‐SOOV immunoglobulin G and SOOV RNA, with 3/6 (50%) in Hongcheon‐gun and 2/5 (40%) in Pyeongchang‐gun. Utilizing a multiplex polymerase chain reaction‐based next‐generation sequencing approach, we achieved complete genomic sequencing of SOOV from rodent lung tissues, with coverage rates of 90.3%−98.2% for the S segment, 92.3%−98.1% for the M segment, and 88.1%−93.0% for the L segment. Five novel whole‐genome sequences of SOOV were obtained from rodents in Hongcheon‐gun and Pyeongchang‐gun, representing the first documented SOOV in Pyeongchang‐gun. The evolutionary rate analysis of SOOV tripartite genomes demonstrated lower divergence in the S segment. Phylogenetic analysis revealed a well‐supported divergence of the SOOV and AMRV lineages across the ROK, China, and Russia, with incongruences suggesting differential segment evolution. Co‐divergence analysis indicated the inter‐species transmission of SOOV Aa18‐104 from Apodemus agrarius in Pyeongchang‐gun. The high zoonotic potential of all SOOV strains underscores the need for extensive monitoring and surveillance. This report provides crucial insights for the development of effective control strategies against hantaviral outbreaks in the ROK.
The Paleo‐Serchio River: history of floods between Lucca and Pisa during the Roman period
Authors: Bini Monica , Caroti Alberto , Cantini Federico , Fabiani Fabio , Fiorentini Marco , Fornaciari Antonio , Isola Ilaria , Lazzarotti Marco , Luppichini Marco , Mensing Scott , Palli Jordan , Piovesan Gianluca , Zanchetta Giovanni 
Published: November 2024

ABSTRACTThe reconstruction of flood frequency beyond the Instrumental Era is challenging and mostly based on historical sources, but it rarely covers more than the last 1000 years when abundant documentation is preserved. To investigate the long‐term trends in flooding and obtain insight into current climatic changes it is necessary to extend these data to a larger number of rivers beyond the Instrumental Era and available period of historical documentation. In this paper we reconstruct the paleoflood record for the Roman Period of the Serchio River (Auser in antiquity, located in Northern Tuscany, Central Italy) using geoarcheological data. The complex hydrological evolution of the river and the development of the important cities of Lucca and Pisa on the river bank allowed an important collection of data, showing a prominent peak in flood activity during the 1st century
ce, which seems to correspond to an increase in regional rainfall interpreted from speleothem proxies. A secondary peak is present in the 6th century
ce, which corresponds locally with an increase in precipitation recorded by speleothems. The phases of increased flooding, when compared with present‐day synoptical meteorological conditions, probably developed during a period of negative North Atlantic Oscillation (NAO) Index, and it is partially supported by comparison with paleoproxies for NAO. These findings confirm that an extensive collection of geoarcheological data, supported by geological and geomorphological investigation, represents a powerful tool to be integrated with historical data for the reconstruction of floods. The concomitance of local paleohydrological proxies can help in disentangling the origin of the signal from other causes.
Resonance Raman Scattering of Topological Insulators Bi2Te3 and Bi2 − xSbxTe3 − ySey Thin Films
Authors: Kumar N. , Surovtsev N. V. , Ishchenko D. V. , Yunin P. A. , Milekhin I. A. , Tereshchenko O. E. , Milekhin A. G. 
Published: November 2024

AbstractPhonon occupation is temperature (T) dependent; it may participate in scattering with electronic states of topological insulators (TIs). Longitudinal optical (LO) phonons and in Bi2 − xSbxTe3 − ySey (BSTS) was resonantly excited by a photon energy (Ep) 2.33 eV due to electronic transition of unoccupied conduction band. The intensity of these modes was enhanced in Bi2Te3 film at Ep 1.87 eV, which is close to the electronic transition of unoccupied Dirac states. Fröhlich coupling strength was the main mechanism for higher intensity of and modes. At 300 K, the intensity of the mode was significantly decayed in both the BSTS and Bi2Te3 at Ep 2.33 and 1.87 eV due to the anharmonic coupling. However, at similar value of T, spectral profile of and modes was not affected because of the lower probability of decay rate of these phonons. In resonant condition, well‐resolved Raman forbidden surface modes were observed at T of 50 K. At 300 K, more asymmetric Fano profile of surface phonon was observed due to the anharmonic coupling. The study indicated that at high T, mode and anharmonic coupling may become primary cause for scattering with electronic states of the TIs. However, at low T, primarily, both the LO phonons participated in the scattering.
Interpretation of antimicrobial function of biosurfactant rhamnolipids using Trisodium 8‐hydroxypyrene‐1,3,6‐trisulfonate‐based fluorescent surfactants
Authors: Kong Shuai , Xiao Haifeng , Zhuoga Baima , Shen Chong , Meng Qin 
Published: November 2024

AbstractThe wide use of antibiotics can lead to antimicrobial resistance. Biosurfactant rhamnolipids are not prone to induce antimicrobial resistance due to their potential to target microbial membranes in both bacteria and fungi. However, the membrane interaction of anionic rhamnolipids with microbials has never been visually observed. This study applied previously synthesized anionic fluorescent Trisodium 8‐hydroxypyrene‐1,3,6‐trisulfonate (HPTS)‐based surfactants, with hydrophobic tails from C8 to C18, to examine their interaction with the plant pathogen Alternaria alternata. The antifungal potency of the surfactants exhibited a positive correlation with the increase in hydrophobic chain length, culminating in C16, which demonstrated the highest activity. Subsequently, a modest reduction in potency was noted for the C18. Fluorescence microscopy confirmed the membrane targeting of HPTS‐C16, and molecular dynamics simulations supported its specific membrane interaction. HPTS‐C16 was notably more effective against spores than mycelium, consistent with its binding affinity. This research provides a fluorescent method to dissect the relationship between surfactant properties and microbial membrane characteristics, guiding the development of antimicrobials to combat resistance.
Clinical Trial Access in Diverse Populations
Authors: Montaque Tareefe , Stewart John 
Published: November 2024

ABSTRACTDespite the disproportionate impact of cancer on minority groups, their participation in oncologic clinical trials remains low. Contributing factors include mistrust of the medical establishment, structural barriers, and implicit bias. Strategies to improve access and representation include pragmatic trial designs, patient navigation programs, financial support, and increasing diversity among medical professionals. Addressing these issues is crucial for ensuring equitable healthcare delivery and improving outcomes for underrepresented populations in clinical research.
Regional variation in demographics, reproduction, and body mass growth rates of wild pigs: Implications for population control
Authors: Snow Nathan P. , Koriakin Kelly J. , Lavelle Michael J. , Glow Michael P. , Fischer Justin W. , Foster Justin A. , Pepin Kim M. , VerCauteren Kurt C. 
Published: November 2024

AbstractWild pigs are a destructive invasive species throughout many regions of the world and have proven difficult to control or eliminate. Their success as an invasive species is, in part, from their high reproductive potential, which can vary based on available resources, ancestry, and other factors. We opportunistically collected data on demographics (i.e., age and sex), reproduction, and body mass on 2,762 wild pigs throughout various research and operation control activities in Texas, Alabama, Hawai'i, Guam (USA), and Queensland (Australia) during 2016–2024. We evaluated these data for differences among study sites that might lead to a better understanding of wild pig ecology and more effective control of their populations. We found that the age structures of wild pigs varied greatly among sites, with areas with more intense control having younger populations. The timing and frequency of birth pulses also varied by site. Large disparities among populations demonstrated the elasticities of wild pigs in invaded ranges; for example, the Alabama study site had a mostly young population with fast body mass growth rates and 2 discernable birth pulses per year, whereas the Guam study site had an older population with slow body mass growth rates and an indistinguishable birth pulse. We hypothesized that intense population control may increase reproduction rates in younger females through increased body mass growth rates and subsequent reproductive maturity. We recommend that managers identify the seasonal birth pulses of wild pigs in their region, and then intensively focus on removing wild pigs during the 115 days (i.e., gestation period) prior to those birth pulses. This may be counterintuitive to managers that focus on trapping after observing a birth pulse, but it increases the probability of simultaneously removing pregnant females and any associated offspring from previous litters that remained with the pregnant female. We also recommend evaluating regional‐specific intensities of removal that might be required for reducing populations with specific emphasis on whether compensatory reproductive behaviors are generated and how to avoid them.
Parkinson's Disease Polygenic Risk Score and Neurological Involvement in Carriers of the FMR1 Premutation Allele: A Case for Genetic Modifier
Authors: Loesch Danuta Z. , Chafota Freddy , Bui Minh Q. , Storey Elsdon , Atkinson Anna , Martin Nicholas G. , Gordon Scott D. , Rentería Miguel E. , Hagerman Randi J. , Tassone Flora 
Published: November 2024

ABSTRACTBackgroundPremutation alleles of the FMR1 X‐linked gene containing CGG repeat expansions ranging from 55 to 200 are associated with diverse late‐onset neurological involvements, including most severe disorder termed Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS). It is intriguing that at least one‐third of male, and a much lower than predicted from the X‐linkage proportion of female carriers are free of this syndrome. This suggests the existence of secondary genetic factors modifying the risk of neurological involvements in these carriers. Considering the occasional presence of parkinsonian features in FXTAS, we explored the possibility that the Parkinson's Disease Polygenic Risk Score (PD PRS) is related to the occurrence of FXTAS or less severe neurological involvements, in premutation carriers.MethodsThe Genome‐wide SNP genotyping and clinical data on neurological status were obtained from 250 unrelated affected and non‐affected male and female adult carriers of the premutation. The medians for the Parkinson’s Disease Polygenic Risk Score (PD PRS) were compared between the groups of asymptomatic and neurologically affected carriers, and the association of PD PRS with neurological involvement in context with the other known risk factors was explored by fitting univariate and multiple logistic regression models.ResultsThere was a significant difference between the medians from the asymptomatic versus neurologically affected (FXTAS+) groups (p = 0.009). The FXTAS+ status was significantly associated with age at testing (p < 0.001), gender (p = 0.026), and with PD PRS (p = 0.021). The contribution of PD PRS remained significant after adjusting for age and gender (p = 0.044).ConclusionsWe have obtained the first evidence for the relationship between PD PRS and the risk of FXTAS or lesser neurological involvements in the FMR1 premutation carriers. This suggests the role of Parkinson's disease polygenic variants as genetic modifiers of the risk of late onset neurological changes in these carriers.
Grifola frondosa Polysaccharide Ameliorates Inflammation by Regulating Macrophage Polarization of Liver in Type 2 Diabetes Mellitus Rats
Authors: Zou Pei , Li Xueyan , Wang Liping , She Ying , Xiao Chenyang , Peng Yang , Qian Xu , Luo Peng , Wei Shaofeng 
Published: November 2024

ScopeGrifola frondosa polysaccharide (GFP) has a positive effect in regulating type 2 diabetes mellitus (T2DM), but the understanding of its regulatory mechanism is still limited. Accumulating evidence suggests that hepatic inflammation is crucial in the onset and progression of insulin resistance (IR) and T2DM. However, the question of whether GFP can modulate T2DM via regulating hepatic inflammation and the underlying mechanism has not yet been reported.Methods and resultsHigh‐fat diet (HFD) fed combined with streptozocin (STZ) injections rat model and Lipopolysaccharides (LPS)‐treated bone marrow‐derived macrophages (BMDM) model are used. The results showed that GFP intervention reduces weight loss and hyperglycemia symptoms, besides lowers FINS, HOMA‐IR, IPGTT‐AUC, and IPITT‐AUC in T2DM rats. Meanwhile, GFP intervention reduces the secretion level of inflammatory factors and increases the secretion level of anti‐inflammatory factors in the liver tissue of T2DM rats. Furthermore, GFP reduces macrophage infiltration in liver tissue, inhibits macrophage M1‐type polarization, and promotes M2‐type polarization.ConclusionsThese results suggest that GFP intervention could attenuate the hepatic inflammatory and insulin resistance in T2DM rats by inhibiting hepatic macrophage infiltration and modulating M1/M2 polarization. The findings provide new evidence for GFP in the early prevention and treatment of T2DM.