bluuebunny/crossref_metadata_2025_split huggingface dataset:
International consensus statement on allergy and rhinology: allergic rhinitis—executive summary
Authors: Wise Sarah K. , Lin Sandra Y. , Toskala Elina 
Published: February 2018

BackgroundThe available allergic rhinitis (AR) literature continues to grow. Critical evaluation and understanding of this literature is important to appropriately utilize this knowledge in the care of AR patients. The International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) has been produced as a multidisciplinary international effort. This Executive Summary highlights and summarizes the findings of the comprehensive ICAR:AR document.MethodsThe ICAR:AR document was produced using previously described methodology. Specific topics were developed relating to AR. Each topic was assigned a literature review, evidence‐based review (EBR), or evidence‐based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus.ResultsOver 100 individual topics related to AR diagnosis, pathophysiology, epidemiology, disease burden, risk factors, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR were addressed in the comprehensive ICAR:AR document. Herein, the Executive Summary provides a synopsis of these findings.ConclusionIn the ICAR:AR critical review of the literature, several strengths were identified. In addition, significant knowledge gaps exist in the AR literature where current practice is not based on the best quality evidence; these should be seen as opportunities for additional research. The ICAR:AR document evaluates the strengths and weaknesses of the AR literature. This Executive Summary condenses these findings into a short summary. The reader is also encouraged to consult the comprehensive ICAR:AR document for a thorough description of this work.
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Authors: Wise Sarah K. , Lin Sandra Y. , Toskala Elina , Orlandi Richard R. , Akdis Cezmi A. , Alt Jeremiah A. , Azar Antoine , Baroody Fuad M. , Bachert Claus , Canonica G. Walter , Chacko Thomas , Cingi Cemal , Ciprandi Giorgio , Corey Jacquelynne , Cox Linda S. , Creticos Peter Socrates , Custovic Adnan , Damask Cecelia , DeConde Adam , DelGaudio John M. , Ebert Charles S. , Eloy Jean Anderson , Flanagan Carrie E. , Fokkens Wytske J. , Franzese Christine , Gosepath Jan , Halderman Ashleigh , Hamilton Robert G. , Hoffman Hans Jürgen , Hohlfeld Jens M. , Houser Steven M. , Hwang Peter H. , Incorvaia Cristoforo , Jarvis Deborah , Khalid Ayesha N. , Kilpeläinen Maritta , Kingdom Todd. T. , Krouse Helene , Larenas‐Linnemann Desiree , Laury Adrienne M. , Lee Stella E. , Levy Joshua M. , Luong Amber U. , Marple Bradley F. , McCoul Edward D. , McMains K. Christopher , Melén Erik , Mims James W. , Moscato Gianna , Mullol Joaquim , Nelson Harold S. , Patadia Monica , Pawankar Ruby , Pfaar Oliver , Platt Michael P. , Reisacher William , Rondón Carmen , Rudmik Luke , Ryan Matthew , Sastre Joaquin , Schlosser Rodney J. , Settipane Russell A. , Sharma Hemant P. , Sheikh Aziz , Smith Timothy L. , Tantilipikorn Pongsakorn , Tversky Jody R. , Veling Maria C. , Wang De Yun , Westman Marit , Wickman Magnus , Zacharek Mark 
Published: February 2018

BackgroundCritical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR).MethodsUsing previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence‐based review (EBR), or evidence‐based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus.ResultsThe ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR.ConclusionThis critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.
An Efficient Aerobic Oxidation Protocol of Aldehydes to Carboxylic Acids in Water Catalyzed by an Inorganic‐Ligand‐Supported Copper Catalyst
Authors: Yu Han , Ru Shi , Zhai Yongyan , Dai Guoyong , Han Sheng , Wei Yongge 
Published: February 2018

AbstractA method for the aerobic oxidation of aldehydes to carboxylic acids in water by using an inorganic‐ligand‐supported copper catalyst was developed. This method was performed with the use of atmospheric oxygen as the sole oxidant under extremely mild aqueous conditions, and furthermore, a wide range of aldehydes with various functional groups were tolerated. The copper catalyst could be recycled and used in successive reactions at least six times without any appreciable degradation in performance. This method is operationally simple and avoids the use of high‐costing, toxic, air/moisture‐sensitive, and commercially unavailable organic ligands. The generality of this method gives it potential to be used on the industrial scale.
Restoration of eastern oyster populations with positive density dependence
Authors: Moore Jacob L. , Puckett Brandon J. , Schreiber Sebastian J. 
Published: February 2018

AbstractPositive density dependence (i.e., Allee effects) can create a threshold of population states below which extinction of the population occurs. The existence of this threshold, which can often be a complex, multi‐dimensional surface, rather than a single point, is of particular importance in degraded populations for which there is a desire for successful restoration. Here, we incorporated positive density dependence into a closed, size‐ and age‐structured integral projection model parameterized with empirical data from an eastern oyster, Crassostrea virginica, population in Pamlico Sound, North Carolina, USA. To understand the properties of the threshold surface, and implications for restoration, we introduced a general method based on a linearization of the threshold surface at its unique, unstable equilibrium. We estimated the number of oysters of a particular age (i.e., stock enhancement), or the surface area of dead shell substrate required (i.e., habitat enhancement) to move a population from an extinction trajectory to a persistence trajectory. The location of the threshold surface was strongly affected by changes in the amount of local larval retention. Traditional stock enhancement with oysters <1 yr old (i.e., spat) required three times as many oysters relative to stock enhancement with oysters between ages 3 and 7 yr old, while the success of habitat enhancement depended upon the initial size distribution of the population. The methodology described here demonstrates the importance of considering positive density dependence in oyster populations, and also provides insights into effective management and restoration strategies when dealing with a high dimensional threshold separating extinction and persistence.
Individual heterogeneity and early life conditions shape growth in a freshwater top predator
Authors: Nater Chloé R. , Rustadbakken Atle , Ergon Torbjørn , Langangen Øystein , Moe S. Jannicke , Vindenes Yngvild , Vøllestad Leif Asbjørn , Aass Per 
Published: February 2018

AbstractBody size can have profound impacts on survival, movement, and reproductive schedules shaping individual fitness, making growth a central process in ecological and evolutionary dynamics. Realized growth is the result of a complex interplay between life history schedules, individual variation, and environmental influences. Integrating all of these aspects into growth models is methodologically difficult, depends on the availability of repeated measurements of identifiable individuals, and consequently represents a major challenge in particular for natural populations. Using a unique 30‐yr time series of individual length measurements inferred from scale year rings of wild brown trout, we develop a Bayesian hierarchical model to estimate individual growth trajectories in temporally and spatially varying environments. We reveal a gradual decrease in average juvenile growth, which has carried over to adult life and contributed to decreasing sizes observed at the population level. Commonly studied environmental drivers like temperature and water flow did not explain much of this trend and overall persistent and among‐year individual variation dwarfed temporal variation in growth patterns. Our model and results are relevant to a wide range of questions in ecology and evolution requiring a detailed understanding of growth patterns, including conservation and management of many size‐structured populations.
Cumulative effects of multiple pain sites in youth with chronic pain
Authors: Basch M.C. , Chow E.T. , Logan D.E. , Borsook D. , Schechter N.L. , Simons L.E. 
Published: February 2018

AbstractBackgroundThe experience of persistent pain in multiple locations is common in youth. Based on current literature, youth with multiple pain sites (MPS) are at risk of experiencing poorer emotional outcomes and a spread of symptoms into late adolescence and adulthood. Little is known regarding the association between MPS with physical and school functioning domains, particularly after initiation of multidisciplinary pain treatment. Therefore, the objective of this study was to examine the association of MPS with disability and school functioning among youth with chronic pain.MethodsA total of 195 patients with chronic pain, aged 8–17, and their parents completed measures assessing patient distress and functioning at a multidisciplinary pain clinic evaluation and at 4‐month follow‐up.ResultsAt evaluation, 63% of patients presented with MPS; 25% reporting MPS endorsed pain in five or more locations. When controlling for relevant demographic and emotional distress factors, MPS were associated with lower school functioning at evaluation with a persistent trend at follow‐up. Although MPS were not a significant predictor of pain‐related disability at evaluation, it emerged as significant at follow‐up.ConclusionsPotentially due to the MPS load and the inverse effects that such a pain state has on function, such patients may be at risk for poorer health and school‐related outcomes. The mechanisms influencing these relationships appear to extend beyond psychological/emotional factors and warrant further investigation in order to aid in our understanding of youth with MPS.SignificanceYouth with MPS may be at risk for experiencing poorer physical and school functioning in comparison with single‐site peers, despite treatment initiation. Further research is warranted to inform assessment and treatment approaches for this subgroup of patients.
Prioritization of antiretroviral therapy in patients with high CD4 counts, and retention in care: lessons from the START and Temprano trials
Authors: Schechter Mauro 
Published: February 2018

AbstractInitiation of antiretroviral therapy is not a once in a lifetime opportunity. In some resource constrained settings financial limitations make it necessary to prioritize treatment initiation for some groups of patients. In developed countries, there are patients who are reluctant to initiate treatment. Subgroup analysis of the START trial can inform recommendations for which patients with CD4 counts >500 cells mm3 temporary postponement of treatment initiation is safer. These include individuals aged <30 years and/or with CD4/CD8 ratio of >0.8 and/or viral load of <5000. This is because these individuals are at very low risk of disease progression in the subsequent 2 to 3 years, the risk is minimally diminished by antiretroviral therapy and is virtually identical in the first 18 months of therapy regardless of treatment initiation. In addition, asymptomatic young individuals are at higher risk of loss‐to‐follow and of low adherence to treatment, and those with low viral loads are less likely to transmit the virus. In addition, lessons from START and Temprano can help design trials to investigate strategies to decrease losses‐to‐follow‐up, while minimizing risks to patients.
Novel radiomic signature as a prognostic biomarker for locally advanced rectal cancer
Authors: Meng Yankai , Zhang Yuchen , Dong Di , Li Chunming , Liang Xiao , Zhang Chongda , Wan Lijuan , Zhao Xinming , Xu Kai , Zhou Chunwu , Tian Jie , Zhang Hongmei 
Published: February 2018

BackgroundLocally advanced rectal cancer (LARC) patient stratification by clinicoradiologic factors may yield variable results. Therefore, more efficient prognostic biomarkers are needed for improved risk stratification of LARC patients, personalized treatment, and prognostication.Purpose/HypothesisTo compare the ability of a radiomic signature to predict disease‐free survival (DFS) with that of a clinicoradiologic risk model in individual patients with LARC.Study TypeRetrospective study.PopulationIn all, 108 consecutive patients (allocated to a training and validation set with a 1:1 ratio) with LARC treated with neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME).Field Strength/SequenceAxial 3D LAVA multienhanced MR sequence at 3T.AssessmentITK‐SNAP software was used for manual segmentation of 3D pre‐nCRT MR images. All manual tumor segmentations were performed by a gastrointestinal tract radiologist, and validated by a senior radiologist. The clinicoradiologic risk factors with potential prognostic outcomes were identified in univariate analysis based on the Cox regression model for the whole set. The results showed that ypT, ypN, EMVI, and MRF were potential clinicoradiologic risk factors. Interestingly, only ypN and MRF were identified as independent predictors in multivariate analysis based on the Cox regression model.Statistical TestsA radiomic signature based on 485 3D features was generated using the least absolute shrinkage and selection operator (LASSO) Cox regression model. The association of the radiomic signature with DFS was investigated by Kaplan–Meier survival curves. Survival curves were compared by the log‐rank test. Three models were built and assessed for their predictive values, using the Harrell concordance index and integrated time‐dependent area under the curve.ResultsThe novel radiomic signature stratified patients into low‐ and high‐risk groups for DFS in the training set (hazard ratio [HR] = 6.83; P < 0.001), and was successfully validated in the validation set (HR = 2.92; P < 0.001). The model combining the radiomic signature and clinicoradiologic findings had the best performance (C index = 0.788, 95% confidence interval [CI] 0.72–0.86; integrated time‐dependent area under the curve of 0.837 at 3 years).Data ConclusionThe novel radiomic signature could be used to predict DFS in patients with LARC. Furthermore, combining this radiomic signature with clinicoradiologic features significantly improved the ability to estimate DFS (P = 0.001, 0.005 in training set and in validation set, respectively), and may help guide individualized treatment in such patients.Level of Evidence: 3Technical Efficacy: Stage 5J. Magn. Reson. Imaging 2018;48:605–614.
Evaluation of Porcine Meat and Bone Meal in Diets for Pond-Raised Hybrid Catfish
Authors: Li Menghe H , Bosworth Brian G , Lucas Penelope M 
Published: February 2018

Abstract
The present study examined effects of various levels (0, 10, 15, 20, and 25%) of porcine meat and bone meal (PMBM) in diets on production and processing characteristics and body composition of pond-raised hybrid catfish (female Channel Catfish Ictalurus punctatus × male Blue Catfish Ictalurus furcatus). Large fingerlings (mean ± SD initial weight per fish = 58 ± 2.3 g) were stocked into 25 0.04-ha earthen ponds at a stocking rate of 14,826 fish/ha. Fish were fed to apparent satiation once a day for 155 d. There were no significant differences in total feed fed, weight gain, or survival among dietary treatments, but fish fed diets containing 10% or more PMBM had significantly greater net yield and a lower feed conversion ratio than fish fed the control diet without PMBM. No significant differences were detected for carcass yield and fillet yield among dietary treatments by ANOVA, but carcass yield and fillet yield decreased and fillet fat levels increased linearly with increasing PMBM levels. Results from the present study demonstrate that 10% PMBM could be used in the diet for an entire growing season without marked impacts on growth, processing yield, or body composition of pond-raised hybrid catfish. Higher PMBM levels up to 25% may be used for short-term feeding when its price is favorable compared with soybean meal. However, cautions should be taken when using high levels of PMBM during the later part of the growth cycle because of the negative effects on processing yield and fillet fat levels.
Survival of Pellet-Reared, Naturalized, and Wild Advanced-Size Largemouth Bass Exposed to Angling and Handling Stressors
Authors: Keretz Kevin R , Dinken Colin P , Allen Peter J , Schramm Harold L 
Published: February 2018

Abstract
Large numbers of advanced-size Largemouth Bass Micropterus salmoides needed for stocking and studies investigating the effects of environmental and angling stressors may be produced using formulated diets. However, fish reared on formulated diets can have lower survival than wild fish. Although survival can be improved by briefly feeding cultured fish a live fish diet prior to stocking (herein, termed naturalization), the time needed for pellet-reared fish undergoing naturalization to show improved and stable survival (i.e., to become naturalized) compared with pellet-reared fish following a series of sublethal stressors has not been determined. Further, the difference in survival of pellet-reared, naturalized, and wild advanced-size Largemouth Bass following exposure to sublethal stressors has not been evaluated under controlled conditions. We conducted experiments to determine (1) the time required for pellet-reared advanced-size (246–373 mm TL) Largemouth Bass to become naturalized following a series of sublethal stressors and (2) differences in survival of pellet-reared, naturalized, and wild advanced-sized Largemouth Bass subjected to two different series of sublethal stressors. Survival was high and did not significantly differ before (85%) and after 1–12 weeks of naturalization (90–100%). Survival was 100% for pellet-reared, naturalized, and wild Largemouth Bass following the series of sublethal stressors. We found no difference in survival among pellet-reared, naturalized, and wild Largemouth Bass challenged with a series of sublethal stressors.
Autosomal Tubulointerstitial Kidney Disease—MUC1 Type: Differential Proteomics Suggests that Mutated MUC1 (insC) Affects Vesicular Transport in Renal Epithelial Cells
Authors: Staubach Simon , Wenzel Andrea , Beck Bodo B. , Rinschen Markus M. , Müller Stefan , Hanisch Franz‐Georg 
Published: February 2018

AbstractAutosomal dominant tubulointerstitial kidney disease associated to the MUC1 gene (ADTKD‐MUC1; formerly MCKD1) belongs to a heterogeneous group of rare hereditary kidney diseases that is prototypically caused by frameshift mutations in the MUC1 repeat domain. The mutant MUC1 (insC) lacks the transmembrane domaine, exhibits aberant cellular topology, and hence might gain a function during the pathological process. To get insight into potential pathomechanisms we perform differential proteomics of extracellular vesicles shed by renal epithelia into the urine of patients. The study is based on three ADTKD patients and individual controls applying iTRAQ/LC–MS/MS. A total of 796 proteins were identified across all biological and technical replicates, and 298 proteins were quantified. A proportion of 47 proteins were fold‐changed species. GO Term Enrichment analysis revealed proteins with significantly changed expression in ADTKD‐associated extracellular vesicles as vesicular transport‐associated proteins. Among these VTA1 is involved in the endosomal multivesicular body pathway associated with transport to lysosomes or export via exosomes. VTA1 is also claimed to play roles as a cofactor of the AAA ATPases VPS4A and VPS4B in the disassembly of ESCRT III. Protein interaction databases list VPS4B, CHMP2A, and IST1 as VTA1 binding partners. (Data are available via ProteomeXchange with identifier PXD008389.)
Engineering Gold Nanorod–Copper Sulfide Heterostructures with Enhanced Photothermal Conversion Efficiency and Photostability
Authors: Leng Chunbo , Zhang Xin , Xu Fanxing , Yuan Yue , Pei Hao , Sun Zhenhua , Li Li , Bao Zhihong 
Published: February 2018

AbstractPlasmonic gold nanorods (Au NRs)–copper sulfide heterostructures have recently attracted much attention owing to the synergistically enhanced photothermal properties. However, the facile synthesis and interface tailoring of Au NRs–copper sulfide heterostructures remain a formidable challenge. In this study, the rational design and synthesis of Au NRs–Cu7S4 heterostructures via a one‐pot hydrothermal process is reported. Specifically, core–shell and dumbbell‐like Au NRs–Cu7S4 heterostructures are obtained with well‐controlled interfaces by employing the Au NRs with different aspect ratios. Both core–shell and dumbbell‐like Au NRs–Cu7S4 have proven effective as photothermal therapy agents, which offer both high photothermal stability and significant photothermal conversion efficiency up to 62%. The finite‐difference time domain simulation results confirm the coupling effect that leads to the enhanced local field as well as the optical absorption at the heterostructure interface. Importantly, these Au NRs–Cu7S4 heterostructures can be compatibly used as an 808 nm laser‐driven photothermal therapy agents for the efficient photothermal therapy of cancer cells in vitro. This study will provide new insight into the design of other noble metal–semiconductor heterostructures for a broad range of applications utilizing surface plasmon resonance enhancement phenomena.