bluuebunny/crossref_metadata_2025_split huggingface dataset:
Professional Tennis Players and their subsceptibility for Obsessive-Compulsive and Depressive Symptoms
Authors: Cappellato G. 
Published: November 2024

Introduction
A moderate sport activity is considered beneficial for both physical and mental health. On the contrary, different studies have shown that professional players may be more vulnerable to suffer from psychological and/or psychiatric disorders.

Objectives
Given the limited information available, the present study aimed to investigate the possible presence of depressive and obsessive-compulsive symptoms or disorders in a group of professional tennis players.

Methods

Twenty-five current or former professional tennis players (18 men and 7 women; mean age ± SD: 42.32 ± 13.45 years), were recruited within the Italian Tennis Federation during an international competition and during a master meeting of coaches. They were compared with a control group, recruited from university students, doctors and nurses. All of them underwent a psychiatric interview with a structured scale and a psychopathological assessment carried out with the Mini-International Neuropsychiatric Interview (MINI), the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Self Assessment Scale for Depression (SAD).

Results
The Y-BOCS total and subscale scores were significantly higher in both current and past athletes than controls. Current athletes showed higher scores at Y-BOCS total, subscales and some items. The majority of the current athletes also showed superstitions and magical thinking.

Conclusions
The present study demonstrated that professional tennis players show a relevant increase of obsessive-compulsive symptoms and supertistions than controls. Interestingly, current athletes resulted more severe than past ones. Taken together, our findings support the notion that agonistic sport activities of high level require intensive training and compliance to strict daily routines that might represent a sort of vulnerability toward the onset of full-blown obsessive-compulsive disorder (as well as other disorders) in more fragile individuals. Not suprisingly, sport psychological support experts are increasingly needed.

Disclosure of Interest
None Declared
Pooled Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone in Patients With Advanced Melanoma
Authors: Long Georgina V. , Larkin James , Schadendorf Dirk , Grob Jean-Jacques , Lao Christopher D. , Márquez-Rodas Iván , Wagstaff John , Lebbé Céleste , Pigozzo Jacopo , Robert Caroline , Ascierto Paolo A. , Atkinson Victoria , Postow Michael A. , Atkins Michael B. , Sznol Mario , Callahan Margaret K. , Topalian Suzanne L. , Sosman Jeffrey A. , Kotapati Srividya , Thakkar Pratik K. , Ritchings Corey , Pe Benito Melanie , Re Sandra , Soleymani Samira , Hodi F. Stephen 
Published: November 2024

PURPOSE
Nivolumab (NIVO) + ipilimumab (IPI) combination and NIVO monotherapy have demonstrated durable clinical benefit in patients with unresectable/metastatic melanoma. This analysis describes long-term overall survival (OS) with the combination or monotherapy pooled across all major company-sponsored trials, as well as clinical factors associated with survival, in patients with immune checkpoint inhibitor (ICI) treatment–naïve unresectable/metastatic melanoma.

METHODS
Data were pooled from six CheckMate studies in ICI treatment–naïve patients receiving NIVO + IPI (NIVO 1 mg/kg + IPI 3 mg/kg or NIVO 3 mg/kg + IPI 1 mg/kg) or NIVO monotherapy (3 mg/kg). OS was assessed for each treatment, as well as in select subgroups. Cox proportional multivariate analysis (MVA) and classification and regression tree (CART) analyses were performed within treatment arms.

RESULTS

Median follow-up for OS was 45.0 months for patients treated with NIVO + IPI (n = 839) and 35.8 months for patients treated with NIVO (n = 536). OS was longer with NIVO + IPI versus NIVO monotherapy (hazard ratio, 0.78 [95% CI, 0.67 to 0.91]), with 6-year OS rates of 52% versus 41%, respectively. Consistent benefit was observed in
BRAF
-mutant and
BRAF
-wild-type patients and those with normal and elevated lactate dehydrogenase (LDH). Numerical difference in OS was also observed across PD-L1 expression levels, although more pronounced with no/low PD-L1 expression. Clinical factors associated with decreased survival in both the MVA and CART analyses were LDH > upper limit of normal with either treatment, age ≥65 years with NIVO + IPI, and the presence of liver metastases with NIVO monotherapy.

CONCLUSION
In this large, pooled nonrandomized retrospective analysis, we observed that NIVO + IPI provides longer OS than NIVO in patients with ICI treatment–naïve advanced melanoma and identifies clinical factors that appear to be associated with survival for each treatment, which may assist with treatment decision making.
Development and Validation of a Predictive Model for Maternal Cardiovascular Morbidity Events in Patients With Hypertensive Disorders of Pregnancy
Authors: Meng Marie-Louise , Li Yuqi , Fuller Matthew , Lanners Quinn , Habib Ashraf S. , Federspiel Jerome J. , Quist-Nelson Johanna , Shah Svati H. , Pencina Michael , Boggess Kim , Krishnamoorthy Vijay , Engelhard Matthew 
Published: November 2024

BACKGROUND:
Hypertensive disorders of pregnancy (HDP) are a major contributor to maternal morbidity, mortality, and accelerated cardiovascular (CV) disease. Comorbid conditions are likely important predictors of CV risk in pregnant people. Currently, there is no way to predict which people with HDP are at risk of acute CV complications. We developed and validated a predictive model for all CV events and for heart failure, renal failure, and cerebrovascular events specifically after HDP.

METHODS:
Models were created using the Premier Healthcare Database. The inclusion criteria for the model dataset were delivery with an HDP with discharge from October 1, 2015 to December 31, 2020. Machine learning methods were used to derive predictive models of CV events occurring during delivery hospitalization (Index Model) or during readmission (Readmission Model) using a training set (60%) to estimate model parameters, a validation set (20%) to tune model hyperparameters and select a final model, and a test set (20%) to evaluate final model performance.

RESULTS:
The total model cohort consisted of 553,658 deliveries with an HDP. A CV event occurred in 6501 (1.2%) of the delivery hospitalizations. Multilabel neural networks were selected for the Index Model and Readmission Model due to favorable performance compared to alternatives. This approach is designed for prediction of multiple events that share risk factors and may cooccur. The Index Model predicted all CV events with area under the receiver operating curve (AUROC) 0.878 and average precision (AP) 0.239 (cerebrovascular events: AUROC 0.941, heart failure: AUROC 0.898, and renal failure: AUROC 0.885). With a positivity threshold set to achieve ≥90% sensitivity, model specificity was 65.0%, 83.5%, 68.6%, and 65.6% for predicting all CV events, cerebrovascular events, heart failure, and renal failure, respectively. CV events within 1 year of delivery occurred in 3018 (0.6%) individuals. The Readmission Model predicted all CV events with AUROC 0.717 and AP 0.022 (renal failure: AUROC 0.748, heart failure: AUROC 0.734, and cerebrovascular events AUROC 0.698). Feature importance analysis indicated that the presence of chronic renal disease, cardiac disease, pulmonary hypertension, and preeclampsia with severe features had the greatest effect on the prediction of CV events.

CONCLUSIONS:
Among individuals with HDP, our multilabel neural network model predicted CV events at delivery admission with good classification and events within 1 year of delivery with fair classification.
Accessible Ungrading
Authors: Ubbesen Molly E. , Bruenger Aaron , Lemer Bronson 
Published: November 2024

Abstract
At the University of Minnesota, Rochester, a small health sciences school, writing faculty piloted their own versions of ungrading catered to the accessibility needs of students. Ubbesen experimented with what she calls “credit-based assessment” where students receive a zero through four score on all assignments. Bruenger experimented with assigning credit or no credit to all assignments. And Lemer experimented with not assigning grades at all until the final required one. This article describes these ungrading schemes, analyzes student responses to them, and promotes ungrading as an accessible practice for teachers and learners.
The Complex Lives of Bees
Authors: Gabay Esther M. , Smith Cheryl Hogue 
Published: November 2024

Abstract
This article discusses and situates various grading practices — such as labor-based grading and specification grading — and their applications within a community college setting. Through two community college instructor voices with two disparate and continuing grading journeys, this article reflects on how these grading practices affect community college students in unforeseen and unjust ways, and ultimately argues that instructors should offer grading choices in order to serve the complex lives and needs of community college students.
Just One More Thing?
Authors: Gabor Catherine 
Published: November 2024

Abstract
This study addresses the paucity of literature on the impact of ungrading — contract grading, specifically — on international students at American colleges. Over the course of four semesters, 307 international and domestic students were surveyed (anonymously) about their perceptions of grading contracts in their writing (and writing-heavy) classes. Specifically, the survey was designed to find out if grading contracts serve as “just another thing” to navigate as international students transition into the Western educational setting and, furthermore, to find out if grading contracts inadvertently do more harm than good. Ultimately, international students perceive more overall benefits than drawbacks of ungrading. However, the data show that international students do find contract grading confusing — especially at first. This article analyzes the sources of confusion along with mitigating topics named by the survey participants, such as fairness, student agency, and stress reduction. The data also show that ungrading practices can serve as a transitional tool to ease international students into American education; a portion of students identify the grading contract as a means of facilitating the transition into American education, rather than as a barrier to it.
Decreased DNA density is a better indicator of a nuclear bleb than lamin B loss
Authors: Bunner Samantha , Prince Kelsey , Pujadas Liwag Emily M. , Eskndir Nebiyat , Srikrishna Karan , Amonu McCarthy Antonia , Kuklinski Anna , Jackson Olivia , Pellegrino Pedro , Jagtap Shrushti , Eweka Imuetiyan , Lawlor Colman , Eastin Emma , Yas Griffin , Aiello Julianna , LaPointe Nathan , Schramm von Blucher Isabelle , Hardy Jillian , Chen Jason , Figueroa Schuyler , Backman Vadim , Janssen Anne , Packard Mary , Dorfman Katherine , Almassalha Luay , Bahiru Michael Seifu , Stephens Andrew D. 
Published: November 2024

ABSTRACT
Nuclear blebs are herniations of the nucleus that occur in diseased nuclei and cause nuclear rupture leading to cellular dysfunction. Chromatin and lamins are two of the major structural components of the nucleus that maintain its shape and function, but their relative roles in nuclear blebbing remain elusive. To determine the composition of nuclear blebs, we compared the immunofluorescence intensity of DNA and lamin B in the main nucleus body to that in the nuclear bleb across cell types and perturbations. DNA density in the nuclear bleb was consistently decreased to about half that of the nuclear body whereas lamin B levels in the nuclear bleb varied widely. Partial wave spectroscopic (PWS) microscopy recapitulated the significantly decreased likelihood of high-density domains in the nuclear bleb versus body, and that it was independent of lamin B level. Time-lapse imaging into immunofluorescence revealed that decreased DNA density marked all nuclear blebs whereas decreased lamin B1 levels only occurred in blebs that had recently ruptured. Thus, decreased DNA density is a better marker of a nuclear bleb than lamin B level.
Developmental Coordination Disorder and Early Childhood Trajectories of Physical Activity
Authors: King-Dowling Sara , Veldhuizen Scott , Wellman-Earl Sarah , Price David , Timmons Brian W. , Kwan Matthew Y. W. , Cairney John 
Published: November 2024

ABSTRACT

Purpose: Developmental Coordination Disorder (DCD) is a common neurodevelopmental disorder characterized by motor impairments and subsequent physical activity (PA) deficits in middle childhood. It is not well understood when this gap in PA emerges. The purpose of the current study was to examine the longitudinal trajectories of device-assessed PA in a large cohort of children with and without DCD from age 4 to 8.

Methods: Children (n = 535, 4- to 5-years old) completed 4 annual assessments as part of a prospective cohort study. Children were classified into 3 groups based on their average performance on the Movement Assessment Battery for Children- 2nd Edition: probable DCD (pDCD) <6th percentile (n = 72); at-risk for DCD (DCDr) between the 6 to 16th percentile (n = 127), and typically developing (TD) >16th percentile (n = 336). Moderate-to-vigorous PA (MVPA) and average PA volume (vector counts per minute) were assessed using ActiGraph accelerometers. A series of linear mixed effects models were used to examine longitudinal PA trajectories between groups.

Results: Children in both the pDCD and DCDr groups engaged in significantly less MVPA compared to the TD group, whereas the deficit in PA volume was only evident in the DCD group. The rate of change did not differ by group indicating that this deficit is relatively consistent across the early childhood period.

Conclusions: Young children with DCD are in a MVPA deficit that persists across early childhood. Early interventions targeting motor skills and PA may help to reduce this gap and promote positive trajectories of health among children with motor difficulties.
Effect of Footwear Longitudinal Bending Stiffness on Energy Cost, Biomechanics, and Fatigue During a Treadmill Half-Marathon
Authors: Perrin Titouan P. , Gerey Romane , Morio Cédric Y.M. , Feasson Léonard , Kerhervé Hugo A. , Rossi Jeremy , Millet Guillaume Y. 
Published: November 2024

ABSTRACT

Introduction: Carbon plates have been used to increase running shoes’ longitudinal bending stiffness (LBS), but their effect during a long duration run remains unknown. Our study aimed to identify the effect of LBS on energy cost of running (Cr), biomechanics, and fatigue during a half-marathon.

Methods: Thirteen well-trained male runners (half-marathon time < 1 h40) performed two half-marathons at 95% of the running speed associated with their second ventilatory threshold on two separate visits, with either high-LBS shoes (HLBS, with carbon-plates) or standard-LBS (SLBS) shoes. Before and after the half-marathon, Cr at 12 km/h with both shoes (two 6-min bouts: Cr12) and ankle plantarflexors (PF) force were measured. During the half-marathon, running kinematics, shoe perceived comfort, and Cr were assessed.

Results: During Cr12 measurements before and after the half-marathon, HLBS was 1.0 ± 2.1% more economical than SLBS (p < 0.001). During the half-marathon, Cr increased with running duration (p = 0.048) but there was no distance × condition effect. HLBS increased contact time (+3%, p = 0.01), decreased metatarsophalangeal joint dorsiflexion (-9%, p = 0.01), and was perceived less comfortable than SLBS, independently from running duration. At the end of the half-marathon, HLBS shoes led to higher PF force loss (-20.0 ± 9.8% vs -13.3 ± 11.0%, p = 0.048).

Conclusions: Adding curved carbon plates in the running shoes slightly improved Cr during short running bouts at low intensity but not during a half-marathon. This discrepancy may be explained by day-to-day Cr variability and variation in shoe comfort. PF fatigue was higher with HLBS shoes but the accentuated fatigue did not further impact the biomechanical perturbations induced by the plates. Our results suggest that carbon plates alone do not provide a significant advantage for half-marathon performance.
Training Effects of Traditional versus Cluster Set Configuration with and without Blood Flow Restriction
Authors: Cornejo-Daza Pedro Jesús , Sánchez-Valdepeñas Juan , Rodiles-Guerrero Luis , Boullosa Daniel , León-Prados Juan A. , Wernbom Mathias , Pareja-Blanco Fernando 
Published: November 2024

ABSTRACT

Purpose: This study compared the effects of four different resistance training (RT) programs that differed in the set configuration (cluster vs. traditional) and the blood flow condition [free-flow (FF) vs. blood flow restriction (BFR)] on strength, neuromuscular and hypertrophic adaptations.

Methods: Forty-two resistance-trained males were randomly assigned into four protocols that differed in the set configuration (TRA: without rest between repetitions vs. CLU: 30 s rest every 2 repetitions) and in the blood flow condition [FF vs. BFR (50% of arterial occlusion pressure)]. Subjects followed an 8-week RT program, twice per week, with similar intensity (55%–65% 1RM), sets (3), repetitions per set (10-6), and resting time (2 minutes) in the full-squat (SQ) exercise. Before and after the RT program, they were evaluated for: 1) muscle size of the vastus lateralis; 2) vertical jump; 3) maximal isometric contraction; 4) progressive loading test; and 5) fatigue test.

Results: BFR-TRA and FF-CLU induced greater increases in 1RM, and velocity against submaximal loads than FF-TRA and BFR-CLU (BFR × time and CLU × time interactions, p = 0.02). The TRA protocols showed greater increases in maximal isometric force than CLU (CLU × time interaction, p = 0.03). BFR did not enhance jump performance unlike the FF protocols (p < 0.01). The TRA protocols induced greater hypertrophy in the distal region of the vastus lateralis than CLU protocols (CLU × time interaction, p = 0.04), with BFR-TRA producing the greatest gains in all vastus lateralis sections.

Conclusions: The different combinations of set configurations and blood flow conditions resulted in highly specific adaptations that illustrate the potential of adaptation for each protocol. The divergent underlying mechanisms of CLU and BFR methodologies may offset each other when combined.
Rady uczelni: regulacje i dobre praktyki
Authors: Woźnicki Jerzy 
Published: November 2024

The Conference of Rectors of Polish Academic Schools (KRASP) was established on 7 June 1997 by rectors representing Polish universities authorised to award doctoral degrees in at least one discipline. KRASP is a representative institution of the higher education and science community within the meaning of the Law on Higher Education and Science. Rectors associated in KRASP may operate within the framework of conferences of rectors of particular types of higher education institutions, as set out in the Statute. Apart from public universities, KRASP members include academic non-public universities, whereas non-academic (vocational) universities authorised to conduct master's degree studies may apply for the status of an associated university. Conferences associating vocational universities may obtain the status of an associated conference. Currently, KRASP consists of 108 academic universities represented by rectors, including 11 non-public universities. In addition, nine universities have the status of associated universities. The Conference stands out with its programmatic achievements, which are related to the development of higher education, including the strategy from 2009, the Act of 2005, the 2015 programme and monographs on the Act of 2018, including the presented book. The Polish Rectors Foundation (FRP) was established on 7 June 2001 by 80 rectors of KRASP member universities. The founders of the Foundation include the rectors of the most renowned Polish universities. Among them are the rectors of member non-public universities. The Foundation began operating on 1 September 2002. The main objective of FRP, established as a non-governmental organisation following a civic initiative by the rectors, is to work towards the development of education, science and culture in Poland, with particular emphasis on higher education, including the support of the scientific, educational and cultural policy of the state. Since 2003, it has been cooperating with the Institute of Knowledge Society (ISW) with the status of a foundation, founded together with the Conference of Non-Public Universities. Both foundations, being public benefit organisations, established together the FRP-ISW think-tank, which has obtained the status of a globally recognised and recognisable centre for research on higher education and science.
Is Pessimism Provably Efficient for Offline Reinforcement Learning?
Authors: Jin Ying , Yang Zhuoran , Wang Zhaoran 
Published: November 2024

We study offline reinforcement learning (RL), which aims to learn an optimal policy based on a data set collected a priori. Because of the lack of further interactions with the environment, offline RL suffers from the insufficient coverage of the data set, which eludes most existing theoretical analysis. In this paper, we propose a pessimistic variant of the value iteration algorithm (PEVI), which incorporates an uncertainty quantifier as the penalty function. Such a penalty function simply flips the sign of the bonus function for promoting exploration in online RL, which makes it easily implementable and compatible with general function approximators. Without assuming the sufficient coverage of the data set (e.g., finite concentratability coefficients or uniformly lower-bounded densities of visitation measures), we establish a data-dependent upper bound on the suboptimality of PEVI for general Markov decision processes (MDPs). When specialized to linear MDPs, it matches the information-theoretic lower bound up to multiplicative factors of the dimension and horizon. In other words, pessimism is not only provably efficient but also, minimax optimal. In particular, given the data set, the learned policy serves as the “best effort” among all policies as no other policies can do better. Our theoretical analysis identifies the critical role of pessimism in eliminating a notion of spurious correlation, which arises from the “irrelevant” trajectories that are less covered by the data set and not informative for the optimal policy. Funding: Z. Yang acknowledges the Simons Institute (Theory of Reinforcement Learning). Z. Wang acknowledges the National Science Foundation [Awards 2048075, 2008827, 2015568, and 1934931], the Simons Institute (Theory of Reinforcement Learning), Amazon, J. P. Morgan, and Two bSigma.
The admission and integration model: first‑hand experiences of staff admitted to a mental health ward
Authors: Turnbull Lorraine Bobbie , Green Eleanor 
Published: November 2024

Background/Aims Over a period of 6 months, four staff members were admitted on separate occasions to a male acute mental health ward for 1 day. The purpose was for participants to gain personal insight into the experiences of patients on the ward. This study aimed to explore the experiences of staff admitted onto the ward and provide a conceptual model to describe the admission process. Methods Feedback was obtained from the study participants via pre- and post-admission questionnaires and a focus group discussion. These qualitative data were thematically analysed to generate the steps in the admission and integration model. Results Admission to the mental health ward was a useful learning experience for staff members in terms of improving empathy for their patients. A model of ward admission and integration based on these experiences was also developed. The model adhered to Maslow's hierarchy of need, where participants had to re-establish deficiency needs following admission onto the ward. Conclusions The study findings have been shared with other hospital staff, and will be used by a new working group to implement improvements in patient care.