bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive factors of mortality of patients with fragility hip fractures at 1 year after discharge: A multicenter, retrospective study in the northern Kyushu district of Japan
Authors: Kimura Atsushi , Matsumoto Yoshihiro , Wakata Yoshifumi , Oyamada Akiko , Ohishi Masanobu , Fujiwara Toshifumi , Ikuta Ko , Tsuchiya Kuniyoshi , Tayama Naohisa , Tomari Shinji , Miyahara Hisaaki , Mae Takao , Hara Toshihiko , Saito Taichi , Arizono Takeshi , Kaji Kozo , Mawatari Taro , Fujiwara Masami , Sakimura Riku , Shin Kunichika , Ninomiya Kenichi , Nakaie Kazutoshi , Antoku Yasuaki , Tokunaga Shoji , Nakashima Naoki , Iwamoto Yukihide , Nakashima Yasuharu 
Published: August 2019

Purpose: Fragility hip fractures (FHFs) are associated with a high risk of mortality, but the relative contribution of various factors remains controversial. This study aimed to evaluate predictive factors of mortality at 1 year after discharge in Japan. Methods: A total of 497 patients aged 60 years or older who sustained FHFs during follow-up were included in this study. Expected variables were finally assessed using multivariable Cox proportional hazards models. Results: The 1-year mortality rate was 9.1% (95% confidence interval: 6.8–12.0%, n = 45). Log-rank test revealed that previous fractures ( p = 0.003), Barthel index (BI) at discharge ( p = 0.011), and place-to-discharge ( p = 0.004) were significantly associated with mortality for male patients. Meanwhile, body mass index (BMI; p = 0.023), total Charlson comorbidity index (TCCI; p = 0.005), smoking ( p = 0.007), length of hospital stay (LOS; p = 0.009), and BI ( p = 0.004) were the counterparts for females. By multivariate analyses, previous vertebral fractures (hazard ratio (HR) 3.33; p = 0.044), and BI <30 (HR 5.42, p = 0.013) were the predictive variables of mortality for male patients. BMI <18.5 kg/m2 (HR 2.70, p = 0.023), TCCI ≥5 (HR 2.61, p = 0.032), smoking history (HR 3.59, p = 0.018), LOS <14 days (HR 13.9; p = 0.007), and BI <30 (HR 2.76; p = 0.049) were the counterparts for females. Conclusions: Previous vertebral fractures and BI <30 were the predictive variables of mortality for male patients, and BMI <18.5 kg/m2, TCCI ≥5, smoking history, LOS <14 days, and BI <30 were those for females. Decreased BI is one of the independent and preventable risk factors. A comprehensive therapeutic approach should be considered to prevent deterioration of activities of daily living and a higher risk of mortality.
KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis
Authors: Isshiki Yusuke , Nakajima-Takagi Yaeko , Oshima Motohiko , Aoyama Kazumasa , Rizk Mohamed , Kurosawa Shuhei , Saraya Atsunori , Kondo Takashi , Sakaida Emiko , Nakaseko Chiaki , Yokote Koutaro , Koseki Haruhiko , Iwama Atsushi 
Published: August 2019

Abstract
KDM2B together with RING1B, PCGF1, and BCOR or BCORL1 comprise polycomb repressive complex 1.1 (PRC1.1), a noncanonical PRC1 that catalyzes H2AK119ub1. It binds to nonmethylated CpG islands through its zinc finger-CxxC DNA binding domain and recruits the complex to target gene loci. Recent studies identified the loss of function mutations in the PRC1.1 gene, BCOR and BCORL1 in human T-cell acute lymphoblastic leukemia (T-ALL). We previously reported that Bcor insufficiency induces T-ALL in mice, supporting a tumor suppressor role for BCOR. However, the function of BCOR responsible for tumor suppression, either its corepressor function for BCL6 or that as a component of PRC1.1, remains unclear. We herein examined mice specifically lacking the zinc finger-CxxC domain of KDM2B in hematopoietic cells. Similar to Bcor-deficient mice, Kdm2b-deficient mice developed lethal T-ALL mostly in a NOTCH1-dependent manner. A chromatin immunoprecipitation sequence analysis of thymocytes revealed the binding of KDM2B at promoter regions, at which BCOR and EZH2 colocalized. KDM2B target genes markedly overlapped with those of NOTCH1 in human T-ALL cells, suggesting that noncanonical PRC1.1 antagonizes NOTCH1-mediated gene activation. KDM2B target genes were expressed at higher levels than the others and were marked with high levels of H2AK119ub1 and H3K4me3, but low levels of H3K27me3, suggesting that KDM2B target genes are transcriptionally active or primed for activation. These results indicate that PRC1.1 plays a key role in restricting excessive transcriptional activation by active NOTCH1, thereby acting as a tumor suppressor in the initiation of T-cell leukemogenesis.
Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1
Authors: Ustun Celalettin , Kim Soyoung , Chen Min , Beitinjaneh Amer M. , Brown Valerie I. , Dahi Parastoo B. , Daly Andrew , Diaz Miguel Angel , Freytes Cesar O. , Ganguly Siddhartha , Hashmi Shahrukh , Hildebrandt Gerhard C. , Lazarus Hillard M. , Nishihori Taiga , Olsson Richard F. , Page Kristin M. , Papanicolaou Genovefa , Saad Ayman , Seo Sachiko , William Basem M. , Wingard John R. , Wirk Baldeep , Yared Jean A. , Perales Miguel-Angel , Auletta Jeffery J. , Komanduri Krishna V. , Lindemans Caroline A. , Riches Marcie L. 
Published: August 2019

Abstract
Presumably, reduced-intensity/nonmyeloablative conditioning (RIC/NMA) for allogeneic hematopoietic cell transplantation (alloHCT) results in reduced infections compared with myeloablative conditioning (MAC) regimens; however, published evidence is limited. In this Center for International Blood and Marrow Transplant Research study, 1755 patients (aged ≥40 years) with acute myeloid leukemia in first complete remission were evaluated for infections occurring within 100 days after T-cell replete alloHCT. Patients receiving RIC/NMA (n = 777) compared with those receiving MAC (n = 978) were older and underwent transplantation more recently; however, the groups were similar regarding Karnofsky performance score, HCT–comorbidity index, and cytogenetic risk. One or more infections occurred in 1045 (59.5%) patients (MAC, 595 [61%]; RIC/NMA, 450 [58%]; P = .21) by day 100. The median time to initial infection after MAC conditioning occurred earlier (MAC, 15 days [range, &lt;1-99 days]; RIC/NMA, 21 days [range, &lt;1-100 days]; P &lt; .001). Patients receiving MAC were more likely to experience at least 1 bacterial infection by day 100 (MAC, 46% [95% confidence interval (CI), 43-49]; RIC/NMA, 37% [95% CI, 34-41]; P = .0004), whereas at least a single viral infection was more prevalent in the RIC/NMA cohort (MAC, 34% [95% CI, 31-37]; RIC/NMA, 39% [95% CI, 36-42]; P = .046). MAC remained a risk factor for bacterial infections in multivariable analysis (relative risk, 1.44; 95% CI, 1.23-1.67; P &lt; .0001). Moreover, the rate of any infection per patient-days at risk in the first 100 days (infection density) after alloHCT was greater for the MAC cohort (1.21; 95% CI, 1.11-1.32; P &lt; .0001). RIC/NMA was associated with reduced infections, especially bacterial infections, in the first 100 days after alloHCT.
Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development
Authors: Lucas Jasmine A. , Schmidt Tiffany M. 
Published: August 2019

Abstract
Background
Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light and have been shown to mediate a broad variety of visual behaviors in adult animals. ipRGCs are also the first light sensitive cells in the developing retina, and have been implicated in a number of retinal developmental processes such as pruning of retinal vasculature and refinement of retinofugal projections. However, little is currently known about the properties of the six ipRGC subtypes during development, and how these cells act to influence retinal development. We therefore sought to characterize the structure, physiology, and birthdate of the most abundant ipRGC subtypes, M1, M2, and M4, at discrete postnatal developmental timepoints.

Methods
We utilized whole cell patch clamp to measure the electrophysiological and morphological properties of ipRGC subtypes through postnatal development. We also used EdU labeling to determine the embryonic timepoints at which ipRGC subtypes terminally differentiate.

Results
Our data show that ipRGC subtypes are distinguishable from each other early in postnatal development. Additionally, we find that while ipRGC subtypes terminally differentiate at similar embryonic stages, the subtypes reach adult-like morphology and physiology at different developmental timepoints.

Conclusions
This work provides a broad assessment of ipRGC morphological and physiological properties during the postnatal stages at which they are most influential in modulating retinal development, and lays the groundwork for further understanding of the specific role of each ipRGC subtype in influencing retinal and visual system development.
Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: A single-institution study, systemic review and meta-analysis
Authors: Wang Bin , Wen Xing-zhu , Zhang Wei , Qiu Ming 
Published: August 2019

Background To evaluate the possible predictive value and clinicopathological characteristics of Delphian lymph node metastasis in papillary thyroid carcinoma. Methods A retrospective analysis of papillary thyroid carcinoma patients with Delphian lymph node metastasis in a single institution and meta-analysis of literature reports were performed. Results In own series, Delphian lymph node metastasis was detected in 19 (9.9%) of 192 papillary thyroid carcinoma patients and was significantly associated with tumor size≥1 cm ( P = 0.003), multifocality ( P = 0.006) and extrathyroid extension ( P < 0.001) in the multivariate analysis. Female was a protective factor for Delphian lymph node metastasis ( P = 0.001). Delphian lymph node metastasis was highly predictive of further central lymph node metastasis (positive predictive value = 89.5%, negative predictive value = 67.6%) and moderately predictive of lateral lymph node metastasis (positive predictive value = 26.3%, negative predictive value = 95.4%). In this meta-analysis, there was a strong correlation between Delphian lymph node metastasis and aggressive clinicopathologic characteristics with regards to multifocality ( P = 0.0008), bilaterality ( P = 0.04), extrathyroid extension ( P < 0.00001), lymphovascular invasion ( P < 0.00001), further central lymph node metastasis ( P < 0.00001) and lateral lymph node metastasis ( P < 0.00001). Conclusions This single-institution observational study and meta-analysis identified that Delphian lymph node metastasis was significantly associated with unfavorable clinicopathological characteristics and had a strong predictive power for further disease in the central compartment. Trial registration The clinical study was retrospectively registered to UMIN clinical trials registry (the registry number: UMIN000033835 ).
The Effects of Water-based Exercise Training in People with Type 2 Diabetes
Authors: SCHEER ANNA S. , NAYLOR LOUISE H. , GAN SENG K. , CHARLESWORTH JONATHON , BENJANUVATRA NAT , GREEN DANIEL J. , MAIORANA ANDREW J. 
Published: August 2019

ABSTRACT

Purpose
To investigate the effects of 8 wk of upright water-based exercise training in people with type 2 diabetes.

Methods
Thirteen participants with type 2 diabetes (54% male; 60.9 ± 9.6 yr, mean ± standard deviation) completed 8 wk of upright water-based exercise training at a moderate intensity (60%–80% of exercise test-derived maximum HR), for 1 h, three times a week (TG). Fourteen participants (64% male; 63.9 ± 9.8 yr) acted as a control group (CG) who maintained their usual activities. Preintervention and postintervention, participants performed cardiopulmonary exercise testing to determine V˙O2peak and one-repetition maximum testing to assess muscular strength. Blood profiles were assessed with standard assays. Body mass index and waist/hip ratio were employed as measures of anthropometry. Endothelium-dependent (brachial artery flow-mediated dilation) and independent (glyceryl trinitrate-mediated) function were assessed using vascular ultrasound.

Results
Water-based training increased V˙O2peak (18.5 ± 4.3 mL·kg−1·min−1 to 21.5 ± 5.4 mL·kg−1·min−1) (P = 0.002), overall muscle strength (123 ± 44 kg to 139 ± 43 kg) and leg strength (92 ± 28 kg to 104 ± 29 kg), compared with the CG (P = 0.001). The effect on pectoral strength (31 ± 17 kg to 35 ± 16 kg) was not significantly different to the CG (24 ± 12 kg to 26 ± 14 kg) (P = 0.08). No change was observed in anthropometry, blood profiles, or glyceryl trinitrate-mediated vascular function. Flow-mediated dilation was increased after training (6.1% ± 2.4% to 6.5% ± 3.0%), compared with controls who demonstrated a slight decrease (6.2% ± 1.6% to 5.4% ± 1.6%) (P = 0.002).

Conclusions
Water-based circuit training was well tolerated and appears to be an effective exercise modality for improving aerobic fitness, strength, and vascular function in people with type 2 diabetes.
Measurement uncertainty of β-lactam antibiotics results: estimation and clinical impact on therapeutic drug monitoring
Authors: Rigo-Bonnin Raúl , Canalias Francesca , El Haj Cristina , González-Hernando María Cristina , Díaz-Troyano Noelia , Soldevila Laura , Benavent Eva , Murillo Oscar 
Published: August 2019

Abstract

Background
Despite that measurement uncertainty data should facilitate an appropriate interpretation of measured values, there are actually few reported by clinical laboratories. We aimed to estimate the measurement uncertainty of some β-lactam antibiotics (β-LA), and to evaluate the impact of reporting the measurement uncertainty on clinicians’ decisions while guiding antibiotic therapy.

Methods
Measurement uncertainty of β-LA (aztreonam [ATM], cefepime [FEP], ceftazidime [CAZ], and piperacillin [PIP]) values, obtained by an UHPLC-MS/MS based-method, was estimated using the top-down approach called the single laboratory validation approach (EUROLAB guidelines). Main uncertainty sources considered were related to calibrators’ assigned values, the intermediate precision, and the bias. As part of an institutional program, patients with osteoarticular infections are treated with β-LA in continuous infusion and monitored to assure values at least 4 times over the minimal inhibitory concentration (4×MIC). We retrospectively evaluated the impact of two scenarios of laboratory reports on clinicians’ expected decisions while monitoring the treatment: reports containing only the β-LA values, or including the β-LA coverage intervals (β-LA values and their expanded measurement uncertainties).

Results
The relative expanded uncertainties for ATM, FEP, CAZ and PIP were lower than 26.7%, 26.4%, 28.8%, and 25.5%, respectively. Reporting the measurement uncertainty, we identified that clinicians may modify their decision especially in cases where 4×MIC values were within the β-LA coverage intervals.

Conclusions
This study provides a simple method to estimate the measurement uncertainty of β-LA values that can be easily applied in clinical laboratories. Further studies should confirm the potential impact of reporting measurement uncertainty on clinicians’ decision-making while guiding antibiotic therapy.
Forestry Aridity Index in Vojvodina, North Serbia
Authors: Gavrilov Milivoj B. , Lukić Tin , Janc Natalija , Basarin Biljana , Marković Slobodan B. 
Published: August 2019

Abstract
In investigating aridity in Vojvodina (a region in the northern part of Serbia), the Forestry Aridity Index (FAI) was used. This index was chosen due to being one of the most suitable indices for the analysis of the interaction of climate and vegetative processes, especially in forestry. The spatial distribution of the FAI for annual and decennial periods, as well as its annual trend, is analysed. Satisfactory compatibility between the low (forest) and high (steppe) FAI values with the forest and steppe vegetation on the Vojvodina terrains was obtained. The calculated values of the FAI showed that there was no particular annual trend. These results correspond to the earlier calculated values of the De Martonne aridity index and the Pinna combinative index. Therefore, it can be concluded that there were no recent changes in aridity during the observed period. Results of the correlation indicate weak linearity between the FAI, and the North Atlantic Oscillation and El-Niño South Oscillation.
Spin coherent quantum transport of electrons between defects in diamond
Authors: Oberg Lachlan M. , Huang Eric , Reddy Prithvi M. , Alkauskas Audrius , Greentree Andrew D. , Cole Jared H. , Manson Neil B. , Meriles Carlos A. , Doherty Marcus W. 
Published: August 2019

AbstractThe nitrogen-vacancy (NV) color center in diamond has rapidly emerged as an important solid-state system for quantum information processing. Whereas individual spin registers have been used to implement small-scale diamond quantum computing, the realization of a large-scale device requires the development of an on-chip quantum bus for transporting information between distant qubits. Here, we propose a method for coherent quantum transport of an electron and its spin state between distant NV centers. Transport is achieved by the implementation of spatial stimulated adiabatic Raman passage through the optical control of the NV center charge states and the confined conduction states of a diamond nanostructure. Our models show that, for two NV centers in a diamond nanowire, high-fidelity transport can be achieved over distances of order hundreds of nanometers in timescales of order hundreds of nanoseconds. Spatial adiabatic passage is therefore a promising option for realizing an on-chip spin quantum bus.
Analyzing the talking book Imagine a world: A multimodal approach to English language learning in a multilingual context
Authors: Lotherington Heather , Tan Sabine , O’Halloran Kay L. , Wignell Peter , Schmitt Andrew 
Published: August 2019

Abstract
In recent years there has been increased academic and professional interest and awareness in approaches to English language teaching (ELT) that take a plurilingual approach. This is often combined with a multimodal stance. The outcome of this combination is an approach to English language teaching that integrates multiple languages and multiple semiotic resources. This paper examines how a plurilingual approach to ELT can be viewed through a multimodal lens by analyzing the construction of a plurilingual talking book created as a student project in an elementary public school. The analysis uses multimodal analysis software to map the interaction of languages and images, in order to determine how these function as meaning-making resources in a multimodal, multiple-language text created by linguistically diverse students with high ELT needs. The findings indicate how combinations of different semiotic resources work together to create meaning, delineates the role of English in meaning-making, and illustrates the children’s multilingual interactions in the creation of their collaboratively composed multimodal talking book.
Validity of the 6-Minute Walk Test and YMCA Submaximal Cycle Test During Midpregnancy
Authors: Tinius Rachel A. , Blankenship Maire , Maples Jill M. , Pitts Bailey C. , Furgal Karen , Norris Elizabeth S. , Hoover Donald L. , Olenick Alyssa , Lambert Joshua , Cade William Todd 
Published: August 2019

Abstract
Tinius, RA, Blankenship, M, Maples, JM, Pitts, BC, Furgal, K, Norris, ES, Hoover, DL, Olenick, A, Lambert, J, and Cade, WT. Validity of the 6-minute walk test and Young Men’s Christian Association (YMCA) submaximal cycle test during midpregnancy. J Strength Cond Res 35(11): 3236–3242, 2021—Submaximal exercise testing can be a feasible alternative to maximal testing within special populations to safely predict fitness levels; however, submaximal exercise testing has not been well-validated for use during pregnancy. The purpose of this study was to determine the concurrent validity of the 6-minute walk test (6MWT) and the YMCA submaximal cycle test (YMCAT) to predict V̇o
2max in physically active women during midpregnancy. Thirty-seven (n = 37) pregnant women (22.1 ± 1.4 weeks' gestation) and 10 (n = 10) nonpregnant women participated in the study. Subjects completed a graded maximal treadmill test at 1 visit to measure maximal oxygen consumption (V̇o
2max), and then subjects completed the 6MWT and YMCAT in randomized order during a separate visit. The predicted V̇o
2max from each submaximal test were compared with the measured V̇o
2max from the treadmill test to assess the validity of these tests during pregnancy. Among pregnant women, predicted V̇o
2max from the YMCAT was not correlated to the measured V̇o
2max (r = 0.14, p = 0.42), and the predicted V̇o
2max from the 6MWT was only moderately correlated (r = 0.40, p = 0.016) to the measured V̇o
2max. Among nonpregnant women, the predicted V̇o
2max values from both the YMCAT and the 6MWT had strong correlations with the measured V̇o
2max values (YMCAT: r = 0.71, p = 0.02; 6MWT: r = 0.80, p = 0.006). Neither test demonstrated concurrent validity among the pregnant sample. The main finding is that the YMCAT is not a valid method to estimate V̇o
2max during midpregnancy (likely due to physiological changes in heart rate [HR] during pregnancy). The 6MWT has potential to be used clinically for estimating fitness as actual and predicted values did positively correlate, and it is not dependent on HR responses to exercise. However, if a precise measure of fitness is needed, then neither test appears to have strong validity for use during midpregnancy.
Association of Health Service Quality with Patient Satisfaction in Primary Healthcare Center of Gedongtengen Yogyakarta
Authors: Mustika Yoan Ajeng , Nugrahaningtyas Wahjuning Utami Jacoba , Sukismanto Sukismanto 
Published: August 2019

Background: Quality of service is an important indicator in measuring patient satisfaction. Based on the results of a preliminary study in 10 patients, in terms of the dimension of reliability quality, 30% said satisfied and 70% less satisfied; in terms of the dimension of empathy quality, 20% said very satisfied and 80% satisfied; in terms of the dimension of assurance, 90% said satisfied and 10% unsatisfied; in terms of the dimension of responsiveness, 10% said very satisfied, 80% satisfied and 10% less satisfied; in terms of the dimension of tangible, 90% said satisfied and 10% less satisfied. the aim of this study is to identify the association between dimension of health service quality and patient satisfaction in Maternal & Child Health and Family Planning Polyclinic at Pimary Healthcare Center (PHC) of Gedongtengen, Yogyakarta.
Methods: This research employed a descriptive analytical method with cross sectional approach. The population consisted of 170 respondents. Samples were taken using purposive sampling, resulting in 119 respondents as samples. Data were statistically tested using Kendall’s Tau.
Results: The results of statistical test indicated that there was a correlation between the dimension of reliability, empathy, assurance, responsiveness, and tangible to patient satisfaction.
Conclusion: There are correlations of the dimensions of reliability, empathy, assurance, responsiveness and tangible with patient satisfaction.