bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of water conservation strategies and benchmark ecotopes for increasing yields in South Africa’s semi-arid croplands
Authors: Hensley Malcolm , Le Roux Pieter AL , Botha J Jacobus , Van Rensburg Leon D 
Published: August 2019

Recently published results regarding South Africa’s cropping potential show that about one third of the arable land is of low potential, located mainly in semi-arid areas, with the main problem being water shortage. This is therefore an appropriate time to review priorities and procedures, for selecting benchmark ecotopes to represent marginal areas, and for research needs with regard to water conservation strategies to mitigate the problems of low yields. Relevant international principles encapsulated in the words agro-ecology, sustainability and socio-economic conditions, are discussed. Relevant new technologies are described, namely: digital soil mapping that will facilitate the identification of benchmark ecotopes; a stochastic procedure to predict rainfall intensity data from daily rainfall that will facilitate runoff predictions; a crop yield cumulative probability procedure that enables sustainability to be described quantitatively. As a case study, results from a successful field experiment using the infield rainwater harvesting production technique on benchmark ecotopes in a semi-arid area, inhabited by subsistence farmers, are presented. The objectives of the study, procedures used and the method of expressing the results are recommended as guidelines for contributing towards mitigating the problem of low crop productivity across a large portion of the arable area in South Africa.
Joint Body‐ and Surface‐Wave Tomography of Yucca Flat, Nevada, Using a Novel Seismic Source
Authors: Toney Liam D. , Abbott Robert E. , Preston Leiph A. , Tang David G. , Finlay Tori , Phillips‐Alonge Kristin 
Published: August 2019

AbstractIn preparation for the next phase of the Source Physics Experiments, we acquired an active‐source seismic dataset along two transects totaling more than 30 km in length at Yucca Flat, Nevada, on the Nevada National Security Site. Yucca Flat is a sedimentary basin which has hosted more than 650 underground nuclear tests (UGTs). The survey source was a novel 13,000 kg modified industrial pile driver. This weight drop source proved to be broadband and repeatable, richer in low frequencies (1–3 Hz) than traditional vibrator sources and capable of producing peak particle velocities similar to those produced by a 50 kg explosive charge. In this study, we performed a joint inversion of P‐wave refraction travel times and Rayleigh‐wave phase‐velocity dispersion curves for the P‐ and S‐wave velocity structure of Yucca Flat. Phase‐velocity surface‐wave dispersion measurements were obtained via the refraction microtremor method on 1 km arrays, with 80% overlap. Our P‐wave velocity models verify and expand the current understanding of Yucca Flat’s subsurface geometry and bulk properties such as depth to Paleozoic basement and shallow alluvium velocity. Areas of disagreement between this study and the current geologic model of Yucca Flat (derived from borehole studies) generally correlate with areas of widely spaced borehole control points. This provides an opportunity to update the existing model, which is used for modeling groundwater flow and radionuclide transport. Scattering caused by UGT‐related high‐contrast velocity anomalies substantially reduced the number and frequency bandwidth of usable dispersion picks. The S‐wave velocity models presented in this study agree with existing basin‐wide studies of Yucca Flat, but are compromised by diminished surface‐wave coherence as a product of this scattering. As nuclear nonproliferation monitoring moves from teleseismic to regional or even local distances, such high‐frequency (>5  Hz) scattering could prove challenging when attempting to discriminate events in areas of previous testing.
Penyuluhan Kewirausahaan Bagi Anggota Kelompok Karang Taruna Di Kelurahan Malaka Sari, Duren Sawit
Authors: Rahmi Rahmi , Purwana Dedi , Purwana Dedi , Aditya Shandy 
Published: August 2019

Kegiatan Pengabdian pada Masyarakat mengenai penyuluhan kewirausahaan bagi anggota Karang Taruna ini diharapkan dapat memberikan pengetahuan dan pemahaman bagi generasi muda dalam menyusun rencana usaha. Kegiatan ini dilaksanakan pada hari Minggu, tanggal 7 Oktober 2018, bertempat di gedung Sony Sugema Colege, Duren Sawit dengan pendanaan dari DIPA BLU Fakultas Ekonomi UNJ yang dihadiri oleh sebanyak 19 orang peserta.
Dalam kegiatan ini dipaparkan tentang kisah sukses, manfaat, risiko, serta tantangan berwirausaha. Setelah itu dibentuk kelompok yang terdiri dari empat hingga lima orang dan mereka diberi tugas untuk menyusun rencana usaha sederhana untuk kemudian dipresentasikan. Ini merupakan aplikasi dari langkah-langkah penyusunan rencana usaha yang telah dipaparkan sebelumnya di materi. Rencana usaha tersebut kemudian diberikan tanggapan dari instruktur serta peserta lain.
Dari kegiatan ini diperoleh wawasan bahwa secara umum generasi muda memiliki ketertarikan tinggi untuk berwirausaha namun tidak memiliki panduan yang jelas dalam pelaksanaannya. Modal pribadi merupakan sumber pendanaan utama yang diharapkan oleh mayoritas para peserta, sementara pinjaman bank merupakan pilihan terakhir. Meski demikian, seluruh peserta menunjukkan determinasi yang kuat untuk mulai berwirausaha.
Effect of a rescue or recurrence dose of lasmiditan on efficacy and safety in the acute treatment of migraine: Findings from the Phase 3 trials (SAMURAI and SPARTAN)
Authors: Loo Li Shen , Plato Brian , Turner Ira , Case Michael , Raskin Joel , dowsett sherie , Krege John 
Published: August 2019

Abstract
Background

We studied the efficacy and safety of a second dose of lasmiditan for acute treatment of migraine.

Methods

SAMURAI and SPARTAN were double-blind, placebo-controlled Phase 3 studies in which individuals with migraine were randomized to oral lasmiditan 50mg (SPARTAN only), 100mg, 200mg, or placebo. Study drug was to be taken within 4 hours (h) of onset of a migraine attack (moderate or severe pain). A second dose of study drug was provided for rescue (patient not pain-free at 2h and took a second dose 2-24h post-first dose) or recurrence (patient pain-free at 2h, but experienced recurrence of mild, moderate, or severe migraine pain and took a second dose 2-24h after first dose). Randomization to second dose occurred at baseline; patients originally assigned lasmiditan were randomized to the same lasmiditan dose or placebo (2:1 ratio), and those originally assigned placebo received placebo. Data from SAMURAI and SPARTAN were pooled for efficacy and safety assessment of a second dose of lasmiditan.

Results

The proportion of patients taking a second dose was lower with lasmiditan versus placebo, and decreased with increasing lasmiditan dose; the majority who took a second dose did so for rescue. In patients taking lasmiditan as first dose, outcomes (pain free, most bothersome symptom [MBS] free) at 2h after a second dose for rescue were similar whether the second dose was lasmiditan or placebo (p>0.05 in all cases). In patients taking lasmiditan for first dose, outcomes at 2h after a second dose for recurrence were as follows: lasmiditan pooled versus placebo - pain free, 50% vs 32% (p>0.05); MBS free, 71% vs 41% (p=0.02); pain relief, 77% vs 52% (p=0.03). In patients whose first dose was lasmiditan, the incidence of treatment emergent adverse events (TEAEs) reported after the second dose was similar whether second dose was lasmiditan or placebo.

Conclusions

A second dose of lasmiditan showed some evidence of efficacy when taken for headache recurrence. There was no clear benefit of a second dose of lasmiditan for rescue treatment. The incidences of TEAEs were similar whether the second dose was lasmiditan or placebo.
Impact of intestinal helminthes infections on malnutrition and haematological indices of school-age children in Gondar town, Ethiopia.
Authors: Lemma Wossenseged , Tarekegn Daniel , Birhanie Meseret 
Published: August 2019

Abstract
Abstract
Background: Ethiopia, the second populous nation in Africa, has been grouped under low income countries. Stunting, underweight and wasting in school children are very common. The aim of this research was to evaluate the impact of intestinal helminthesand schistosomiasison malnutrition, anaemiaand haematological indices in the school age children of Azezo Elementary School in Gondar town.
Methods:Kato Katz technique was performed todetermine infection and intensity of intestinal helminthinfections. AnthroPlus software version 1.04 (WHO, Geneva, Switzerland) was used to get malnutrition indiceswhile fully-automated hematologicalcell counter (Mindray BC-3200) andMindray BS-200E chemistry analyser were used to determine haematological and biochemical parametrs.
Results: Atotal of 384 school childrenwere recruited in this study.The overall prevalence of helminthes infections was 45.8% (178/384) with the leading Ascarislumbericoides infection (20.6%) compared to the second leading Schistosomamansoni(17.4%)and third leading hook worm infections (13.3%).The prevalencesof body mass indexes for age Z-scores (BAZ) indices were 9.6% (37) wasting, 17.2%(66) sever thinness, 38.5%(148) thinness, 34.1% (131) normal and 0.5%(2) overweight. On the other hand, the prevalences of height for age Z-scores (HAZ) indices were 12.2%(47) stunt, 87%(334) normal and 0.8%(3) over height.Of the total 384 school age children, 335(87.2%) had normal blood glucose level (70 – 110 mg/dL) while the remaining 49 (12.8%) school age children were hypoglycemic. The number of the school children with normal total protein level (6.6 – 8 g/dL) was 259(67.4%) while the remaining 125(32.6%) school children were hypo-proteinaemic. The prevalence of anemia in the school age children was 33.1%(127).Intestinal helminthes infections were statistically significantly associated (p = 0.000) with hypo-glycemia, hypo-proteinaemia and anemia compared with non-infected school children. The likelihood of anemia in intestinal helminth infected school children, when it was compared with uninfected was 148 times higher for both Ascarislumbericoides-Schistosomamansoni co-infection, 38 times for Hook worm, 20 times for Schistosomamansoni and 3 times for Ascarislumbericoidesmono-infection.
Conclusion: Intestinal helminth infections in school age children aggravate malnutrition. Prolonged malnutrition and intestinal helminth infections could result in stunting in school-age children.
Prevalence of and risk factors for chronic kidney disease and diabetic kidney disease in a central Chinese urban population: a cross-sectional survey
Authors: Duan Jiayu , Duan Guang-Cai , Wang Chong-Jian , Liu Dong-Wei , Qiao Ying-Jin , Pan Shao-Kang , Jiang Deng-Ke , Liu Yong , Zhao Zi-Hao , Liang Lu-Lu , Tian Fei , Liu Zhang-Suo 
Published: August 2019

Abstract
Background

This study was conducted to evaluate and update the current prevalence of and risk factors for chronic kidney disease (CKD) and diabetic kidney disease (DKD) in a China.

Methods

A total of 5231 participants were randomly recruited for this study. CKD and DKD were defined according to the combination of estimated glomerular filtration rate (eGFR), presence of albuminuria and diabetes. Participants completed a questionnaire assessing lifestyle and relevant medical history, and blood and urinary specimens were taken. Serum creatinine, uric acid, total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein and urinary albumin were assessed. The age- and gender-adjusted prevalences of CKD and DKD were calculated, and risk factors associated with the presence of reduced eGFR, albuminuria, DKD, severity of albuminuria and progression of reduce renal function were analyzed by binary and ordinal logistic regression.

Results

The overall adjusted prevalence of CKD was 16.8% (15.8 – 17.8%) and that of DKD was 3.5% (3.0 – 4.0%). Decreased renal function was detected in 132 participants [2.9%, 95% confidence interval (CI): 2.5 – 3.2%], whereas albuminuria was found in 858 participants (14.9%, 95% CI: 13.9 – 15.9%). In all participants with diabetes, the prevalence of reduced eGFR was 6.3% (95% CI = 3.9 – 8.6%) and that of albuminuria was 45.3% (95% CI = 40.4 – 50.1%). The overall prevalence of CKD in participants with diabetes was 48.0% (95% CI = 43.1 – 52.9%). The results of the binary and ordinal logistic regression indicated that factors independently associated with higher risk of reduced eGFR and albuminuria were older age, gender, smoking, alcohol consumption, overweight, obesity, diabetes, hypertension, dyslipidemia and hyperuricemia.

Conclusions

Our study shows the current prevalences of CKD and DKD in residents of Central China. The high prevalence suggests an urgent need to implement interventions to relieve the high burden of CKD and DKD in China.
The precursor for nerve growth factor (proNGF) is not a serum or biopsy-rinse biomarker for thyroid cancer diagnosis
Authors: Rowe Christopher W , Faulkner Sam , Paul Jonathan W , Tolosa Jorge M , Gedye Craig , Bendinelli Cino , Wynne Katie , McGrath Shaun , Attia John , Smith Roger , Hondermarck Hubert 
Published: August 2019

Abstract
Background: Nerves and neurotrophic growth factors are emerging promoters of cancer growth. The precursor for Nerve Growth Factor (proNGF) is overexpressed in thyroid cancer, but its potential role as a clinical biomarker has not been reported. Here we have examined the value of proNGF as a serum and biopsy-rinse biomarker for thyroid cancer diagnosis. Methods: Patients presenting for thyroid surgery or biopsy were enrolled in separate cohorts examining serum (n=204, including 46 cases of thyroid cancer) and biopsy-rinse specimens (n=188, including 26 cases of thyroid cancer). ProNGF levels in clinical samples were analysed by ELISA. Multivariate statistical analyses testing for potential confounders were used to compare proNGF levels with clinicopathological parameters. Results: ProNGF was not detected in the majority of serum samples 176/204 (86%) and the detection of proNGF was not associated with thyroid cancer diagnosis. In the few cases where proNGF was detected in the serum, thyroidectomy did not affect proNGF concentration, demonstrating that the thyroid was not the source of serum proNGF. Intringuingly, an association between hyperthyroidism and serum proNGF was observed (OR 3.3, 95%CI 1.6-8.7 p=0.02). In biopsy-rinse, proNGF was detected in 73/188 (39%) cases, with no association between proNGF and thyroid cancer. However, a significant positive association between follicular lesions and biopsy-rinse proNGF was found (OR 3.3, 95% CI 1.2-8.7, p=0.02). Conclusions: ProNGF levels in serum and biopsy-rinse are not increased in thyroid cancer and therefore proNGF is not a clinical biomarker for this condition.
Renal involvement as the first symptom of multiple myeloma
Authors: Du Yongjing , Zhang Ping , Zhong Xiang , Chen Shasha , Li Guisen , Wang Li , wang wei 
Published: August 2019

Abstract
Background . Renal involvement is a common complication of multiple myeloma (MM). However, most studies have focused on renal failure in MM, and little information is available about the other renal manifestations in MM and their association with immunophenotypes and renal pathology. Methods . We retrospectively analyzed the clinical, laboratory and pathology data of 283 MM patients treated in Sichuan Provincial People’s Hospital, West China, between January 1990 and May 2017. The patients were divided into a renal involvement group (n = 200) and a non-renal involvement group (n = 83). Results. In the renal involvement group, 90 (45.0%) patients were diagnosed with MM in the Nephrology department, and isolated proteinuria, renal failure and nephrotic syndrome were detected in 90(45.0%), 94 (47.0%) and 58 (29.0%) patients, respectively. 135 patients with renal involvement underwent immunofixation electrophoresis, and IgG, IgA, IgD, IgE, pure light chain and nonsecretory MM were detected in 52 (38.5%), 32 (23.7%), 1 (0.7%), 1 (0.7%), 45(33.3%) and 4 (3.0%) patients, respectively. 47 patients without renal involvement also underwent immunofixation electrophoresis, and IgG and IgA MM were found in 24 (51.0%) and 18 (38.3%) patients, respectively. Severe anemia and hypertension, hypercalcemia and pure light chain were more frequent in patients with renal involvement (P < 0.05).9 patients with renal involvement were performed renal biopsy, and cast nephropathy, renal amyloidosis were proved in 5 and 4 patients, respectively. Conclusions. Renal involvement was common at MM diagnosis and had diverse clinical manifestations. The most common clinical manifestations include renal failure, isolated albuminuria and nephrotic syndrome. Nephrologists should rule out MM in patients presenting with renal involvement.
KAWASAKI DISEASE IN INFANTS LESS THAN ONE YEAR OF AGE: AN ITALIAN COHORT FROM A SINGLE CENTER
Authors: Mastrangelo Greta , Cimaz Rolando , Calabri Giovan Battista , Simonini Gabriele , Lasagni Donatella , Resti Massimo , Trapani Sandra 
Published: August 2019

Abstract
Background and aims

Few data are currently available for Kawasaki disease (KD) below 12 months especially in Caucasians. This study aims to analyze clinical and laboratory features of KD among an Italian cohort of infants.

Methods

A retrospective chart review of KD children aged less than one year at time of disease onset between January 2008-December 2017 was performed. Clinical data, laboratory parameters, instrumental findings, treatment and outcome were collected in a customized database.

Results

Among 113 KD patients, 32 (28.3%) were younger than 1 year. Nineteen patients aged below 6 months, and three below 3 months. The median age was 5.7 ±2.7 months. The mean time to diagnosis was 7±3 days and was longer in the incomplete forms (8 ± 4 vs 6 ± 1 days). Conjunctival injection was present in 26 patients (81.2%); rash in 25 (78.1%); extremity changes in 18 (56.2%); mucosal changes in 13 (40.6%,) and lymphadenopathy only in 7 (21.8%). Mucosal changes were the least common features in incomplete forms (18.2%). Twenty-two patients (68.7%) had incomplete KD. Nineteen (59.4%) had cardiac involvement, of whom 13 (59.0%) had incomplete form. ESR, PCR and platelet values were higher in complete KD; especially, ESR resulted significantly higher in complete forms (80 ± 25.7 mm/h vs 50 ± 28.6 mm/h; p = 0.01). Conversely, AST level was statistically significant higher in patients with incomplete forms (95.4 ± 132.7 UI/L vs 29.8 ± 13.2 UI/L; p = 0.03). All patients received IVIG. Response was reported in 26/32 patients; 6 cases needed a second dose of IVIG and one required a dose of anakinra.

Conclusion

In our cohort, incomplete disease was commonly found, resulting in delayed diagnoses and poor cardiac prognosis. Infants with incomplete KD seem to have a more severe disease and a greater predilection for coronary involvement than those with complete KD. AST was significantly higher in incomplete forms, thus AST levels might be a new finding in incomplete forms’ diagnosis. Eventually, we highlight a higher resistance to IVIG treatment. To our knowledge this is the first study involving an Italian cohort of patients with KD below 12 months.
Sporting programs aimed at inactive population groups in the Netherlands: factors influencing their long-term sustainability in the organized sports setting
Authors: Ooms Linda , Kruijsbergen Mette van , Collard Dorine , Leemrijse Chantal , Veenhof Cindy 
Published: August 2019

Abstract
Background: The organized sports sector has received increased interest as a setting to stimulate physical activity among inactive target groups. To include many inactive people and to obtain population health benefits, it is important that effective sporting programs are sustained (i.e. continuation of program activities) over a long period of time. This study identified the factors influencing the long-term sustainability of these kind of sporting programs located within local sports clubs in the Netherlands.
Methods: Fourteen Dutch sporting programs aimed at increasing physical activity levels of inactive population groups and funded within the National Action Plan for Sport and Exercise (NAPSE) were the focus of this study. The programs were developed by ten Dutch National Sports Federations (NSFs) and implemented by different sports clubs in the Netherlands within a three-year funded implementation period (2008-2011). This research consisted of semi-structured face-to-face interviews with the program coordinators of the NSFs (n=14) and semi-structured telephone interviews with representatives of sports clubs that provided the programs (n=17 continued the program, n=11 discontinued the program) six and a half years after the funding period ended (November 2017-March 2018). A sustainability framework with five pre-specified main themes (i.e. program design, implementation, trainer/coach, organizational setting, broader community environment) guided data collection and (deductive) thematic analysis.
Results: Ten of the fourteen NAPSE funded sporting programs were sustained at the level of the NSFs. Most factors facilitating (+) and impeding (-) the long-term sustainability of the programs were common to both NSFs and sports clubs, like program adaptation (+) and a lack of program financing (-). Program evaluation (+) and high program costs (-) were specific factors mentioned by NSFs, while factors related to human resources (e.g. lack of volunteers (-)) or the sports club nature (e.g. social aspect in program design (+)) applied to sports clubs. The factors were summarized in the form of a checklist.
Conclusions: Key factors influencing the long-term sustainability of the sporting programs were identified. The results can be used to develop strategies to promote long-term sustainability of these kind of programs and inform funding guidelines in countries with a similar organized sports infrastructure.