bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atrial Fibrillation Ablation During Hospitalization for Acute Heart Failure: Feasibility and Role of Pulsed Field Ablation
Authors: Marek Josef , Stojadinović Predrag , Wichterle Dan , Peichl Petr , Hašková Jana , Borišincová Eva , Štiavnický Petr , Čihák Robert , Šramko Marek , Kautzner Josef 
Published: November 2024

ABSTRACTIntroductionAtrial fibrillation (AF) can cause or aggravate heart failure (HF). Catheter ablation (CA) is an effective treatment for AF. This study focused on the feasibility and outcomes of emergent AF ablation performed during hospitalization for acute HF.Methods and ResultsWe retrospectively investigated patients who underwent emergent CA for AF during hospitalization for acute HF in 2018–2024. Arrhythmia recurrence was the primary endpoint. The combination of arrhythmia recurrence, HF hospitalization, and all‐cause death was the secondary endpoint. Patients were censored 1 year after the index procedure. We included 46 patients, 35% females, with median age of 67 [interquartile rage: 61, 72] years and left ventricular ejection fraction (LVEF) of 25 [23, 28]%. Thermal CA was performed in 14 patients, and pulsed field ablation (PFA) in 32 patients. Procedure time was significantly shorter with PFA compared to thermal CA (77 [57, 91] vs. 166 [142, 200] minutes, p < 0.001). Fluoroscopy time was longer with PFA (9.5 [7.6, 12.0] vs. 3.9 [2.9, 6.0] minutes, p < 0.001), with a borderline trend towards higher radiation dose (75 [53, 170] vs. 50 [30, 94] μGy.m2, p = 0.056). Extrapulmonary ablation was frequent (86% and 84% for thermal CA and PFA, p > 0.9). The estimated freedom from the primary endpoint was 79% after PFA and 64% after thermal CA (p = 0.44). The estimated freedom from the secondary endpoint was 76% after PFA and 57% after thermal CA (p = 0.43). LVEF improved by 24% ± 2% (p < 0.001) in patients with the first manifestation of HF and by 14% ± 4% (p = .004) in patients with decompensated HF diagnosed earlier.ConclusionsEmergent CA of AF during acute HF hospitalization is safe and associated with improved LVEF and good clinical outcomes. In the PFA era, the rate of these procedures is progressively increasing as they are readily available and easy to perform compared to thermal ablation.
Abnormal Expression of COX5B Gene and Disorder of Mitochondrial Function in Cryptorchid Rats
Authors: Wang Xuehan , Miao Dashuai , Ye Songyi , Xian Hua , Ge Wenliang 
Published: November 2024

ABSTRACTCryptorchidism is one of the most common congenital malformations in the paediatric genitourinary tract. Data analysis of cryptorchidism‐related datasets in the GEO database and gene sequencing results from our institution, along with bioinformatic analysis of the merged mitochondrial gene datasets, revealed that COX5B is differentially expressed in the testes of children with cryptorchidism. Its encoded protein has attracted our attention as a key component of the mitochondrial respiratory chain complex IV. This study aims to explore the COX5B gene expression changes and related mitochondrial issues in cryptorchid rats. For this purpose, we established a cryptorchid rat model by surgery and used molecular biology and biochemistry techniques to detect and analyse the expression level of the COX5B gene and mitochondrial function indexes. The results indicated a significant decrease in COX5B gene expression in the affected testis of cryptorchid rats. The knockdown of COX5B expression in TM3 cells could be observed as the aggravation of cellular senescence, which led to the reduction of proliferation, as well as accompanied by the obvious disorders of mitochondrial function, including the increase of ROS and the decrease of ATP, in which MMP was significantly reduced. This suggests that the COX5B gene may play an important role in cryptorchid testis‐induced reproductive system damage and may be a new target for small molecule‐targeted therapy.
Trichophyton mentagrophytesITS genotype VII infections among men who have sex with men in France: An ongoing phenomenon
Authors: Jabet A. , Bérot V. , Chiarabini T. , Dellière S. , Bosshard P. P. , Siguier M. , Tubiana R. , Favier M. , Canestri A. , Makhloufi S. , Nouchi A. , de Risi‐Pugliese T. , Boquel F. , Crémer G. , Khoury R. , Sidali O. , Hamane S. , Benderdouche M. , Palous M. , Chasset F. , Gräser Y. , Hubka V. , Fekkar A. , Hennequin C. , Piarroux R. , Normand A.‐C. , Monsel G. 
Published: November 2024

AbstractBackgroundTrichophyton mentagrophytes ITS genotype VII (TMVII) has recently been identified in France as the causative agent of dermatophyte infections transmitted during sexual activity among men who have sex with men (MSM).ObjectivesOur objective was to provide new insights into the epidemiology, clinical presentation and treatment of TMVII infections based on cases diagnosed from October 2022 to September 2023 in three medical mycology laboratories in Paris. Additionally, we aimed to perform molecular characterization of TMVII strains collected in Paris, as well as in Switzerland.MethodsWe identified all isolates from skin and hair belonging to the T. mentagrophytes complex by sequencing the ITS region. For isolates corresponding to TMVII, clinical data were retrieved from medical records. For all available TMVII strains that we isolated since January 2021, we sequenced tef1α and tubb and determined the MAT locus idiomorph.ResultsWe identified 32 cases of TMVII Infections. All cases occurred in men, 30 of whom reported having sex with men. Fifteen cases were sporadic cases including four among sex workers. The other 17 cases belonged to a single cluster involving a tantric masseur who infected 15 clients and his roommate. The median time from massage to lesion onset was 16 [2–52] days. Except for one patient, all other patients received systemic antifungal treatment with terbinafine. We observed five patients whose cultures remained positive even after 3–4 weeks of treatment and five patients experienced a relapse of the infection after discontinuing antifungal treatment. All French isolates exhibited identical tef1α and tubb sequences, as well as the same MAT idiomorph locus. They displayed variations in the tef1α sequence compared to isolates from Switzerland and the Czech Republic.ConclusionsWe confirm the active circulation of TMVII among MSM in France, which is associated with challenges in diagnosis, treatment and prevention.
Assessing the Impact of a Structured Capsule Endoscopy Training Program Using a New Validated Assessment Tool
Authors: Lima Capela Tiago , Gonçalves João Carlos , Ferreira Ana Isabel , Macedo Silva Vítor , Macedo Cláudia , Arieira Cátia , Xavier Sofia , Cúrdia Gonçalves Tiago , Boal Carvalho Pedro , Dias de Castro Francisca , Magalhães Joana , Rosa Bruno , Moreira Maria João , Cotter José 
Published: November 2024

ABSTRACTBackground and AimWe aimed to develop and validate a simple capsule endoscopy (CE) training assessment tool, the Capsule Endoscopy Training Assessment (CETA), and prospectively use it to analyze the learning progression achieved by participants in our CE training program.MethodsOver a 3‐year period, all participants in our CE training program completed pre‐training and post‐training CETA, ranging between 0% and 100%, and encompassing theoretical questions and interpretation of segmented CE videos. We compared the mean differences in overall, theoretical, and practical pre‐training and post‐training CETA, and assessed the influence of previous endoscopic experience (upper gastrointestinal endoscopy [UGE], colonoscopy, device‐assisted enteroscopy [DAE] and CE) using generalized linear models.ResultsFifty‐seven participants were included. After training, there was a significant increase in participants' overall (mean difference, 26.3; 95% confidence interval [CI], 20.70 to 31.83), theoretical (mean difference, 27.2; 95% CI, 19.81 to 34.57), and practical (mean difference, 25.9; 95% CI, 20.09 to 31.63) CETA components. Compared to those without experience, participants with previous endoscopic experience demonstrated a smaller increase in overall CETA after training (UGE, rate ratio, 0.76; 95% CI, 0.63 to 0.91; colonoscopy (rate ratio, 0.80; 95% CI, 0.67 to 0.95; DAE (rate ratio, 0.84; 95% CI, 0.73 to 0.97; CE, rate ratio, 0.81; 95% CI, 0.72 to 0.92, respectively).ConclusionCETA is a valid and useful tool in assessing the learning progression achieved by participants following the CE training program. We demonstrated a significant improvement in participants' CETA after training, being the least experienced participants in endoscopic procedures who benefited the most from CE training.
Consolidating the evidence on the effectiveness of strategies to promote vegetable intake in priority settings: An overview of systematic reviews
Authors: Brooker Paige G. , Poelman Astrid A. M. , Livingstone Katherine M. , Collins Clare E. , Mihrshahi Seema , Sambell Ros , Wu Jason H. Y. , Hendrie Gilly A. 
Published: November 2024

AbstractBackgroundEffective interventions to increase vegetable intake are urgently needed. This systematic rapid review aimed to summarise the effectiveness of interventions targeting increased vegetable intakes across diverse settings.MethodologyThe review was guided by the conduct of rapid reviews from the Cochrane Handbook. The literature was searched in February 2024 across PubMed, Web of Science and Cochrane Central for systematic review articles published since 2014. The Risk of Bias In Systematic Reviews tool was used and characteristics of reviews synthesised narratively with intervention effectiveness results were summarised.ResultsA total of 20 systematic reviews met the eligibility criteria. Most targeted school‐based settings (n = 7) or community/home‐based settings (n = 4). Early childhood education and workplaces had one review each, with none in retail, secondary or tertiary education, food service, food relief or aged care. The mean change in vegetable consumption was +0.12 serves per day, with increases of up to +0.42 serves reported (range −0.09 to +0.42). By setting, the largest increases were reported for interventions in school settings (+0.42 serves/day), followed by home (+0.38 serves/day). Almost half the studies reporting effect sizes suggested no effect on intake (46%), 41% suggested a small effect and 13% suggested a medium effect. Greater effect sizes were achieved in interventions implemented across multiple settings.ConclusionsReview findings indicate that the average increase in vegetable intake following interventions is about one‐eighth of a serve but up to almost half a serve in some settings. An increase of this magnitude could have a substantial population impact, particularly in population groups with persistently low intakes.
Dietary counselling to increase soluble fibre in patients with gynaecological cancers undergoing pelvic radiotherapy: A feasibility study
Authors: Croisier Emilie , Brown Teresa , Grigg Alice , Chan Philip , Bauer Judy 
Published: November 2024

AbstractBackgroundThis study aimed to determine the feasibility of increasing soluble fibre intake via dietary counselling to improve gastrointestinal toxicity and quality of life in patients with gynaecological cancers undergoing pelvic radiotherapy without adverse consequences on radiation treatment (RT) delivery accuracy.MethodsA single‐arm, single‐centre intervention feasibility trial included patients with gynaecological cancers undergoing pelvic RT ± chemotherapy at a tertiary hospital. Participants were provided weekly dietary counselling over the duration of their RT (5–6 weeks) to increase soluble fibre intake incrementally each week. Stakeholder surveys were also completed.ResultsIn total, 9 of 14 eligible patients participated (55 years old [SD 13.2], diagnosis: cervical [n = 3], endometrial/uterine [n = 5] and vaginal [n = 1]), with the majority categorised as low fibre consumers at baseline (n = 6). On average, soluble fibre intake increased by 150% throughout treatment. There were no adverse events or major adjustments required for RT delivery. There were improving trends in the functional subset identified. Results may be confounded by the sample size resulting from limited eligibility (n = 14) and a high attrition rate (n = 4).ConclusionsMost participants successfully increased their soluble fibre intake throughout treatment, without significant adverse events noted for RT delivery accuracy. These results provide preliminary data to calculate the sample size required to produce meaningful effect sizes. However, this study highlighted challenges in participant recruitment and retention, with limited organisational support and perceived compatibility.
Advance care planning for patient with chronic obstructive pulmonary disease: An evolutionary concept analysis
Authors: Minami Kotoko , Kamei Tomoko 
Published: November 2024

AbstractAimThis study aimed to analyze the concept of advance care planning (ACP) for patients with chronic obstructive pulmonary disease (COPD), by systematically clarifying the attributes, antecedents, consequences, surrogate terms, related concepts, and historical transition of the concept.MethodsFollowing Rodgers' method of concept analysis, the academic development of concepts related to ACP for patients with COPD, as well as changes in the concept over time, is comprehensively organized and described. A search formula for relevant literature was created using the two keywords “chronic obstructive pulmonary disease” and “advance care planning”. The databases of CENTRAL, PubMed, CINAHL Plus with Full Text, Embase, and PsycInfo were searched without limitation by the year of publication and restricted to English and Japanese languages.ResultsOf the 3433 retrieved articles, 30 peer‐reviewed articles were included in the analysis. Data extraction was conducted to identify concepts relevant to ACP for patients with COPD, resulting in the identification of four antecedents (COPD progression, decline in QOL, attitude toward facing death and dying, and interdisciplinary team approach); four attributes (discussion process, documentation, support for facing death, and dying, holistic approach); and four consequences (dialogical process, improved support of decision‐making, physical impacts, and psychological impacts).ConclusionsThis conceptual framework, identified through this analysis, shows an evolution from a medical perspective to encompassing humanistic perspectives in addressing patient needs and emphasizes the importance of nursing practices. The elucidated concept characteristics may enhance its application, practice promotion, and interdisciplinary understanding across healthcare professions in the end‐of‐life field.
Family‐Centered Antenatal Care With a Life‐Limiting Fetal Condition: A Developmental Theory‐Guided Approach
Authors: Henry Carrie J. , Côté‐Arsenault Denise 
Published: November 2024

AbstractTrisomy 18 (T18) is the second‐most common autosomal trisomy and includes multiple anomalies, growth restriction, and a severely shortened life span, often lasting only hours or days. Côté‐Arsenault and Denney‐Koelsch extended Reva Rubin's work, describing the psychosocial stages of pregnancy by describing the stages and developmental tasks for a pregnancy altered by a life‐limiting fetal condition such as T18. When a diagnosis of T18 is made prenatally, the pregnancy changes dramatically, although it remains a psychosocial developmental process. The extended stages of pregnancy with T18 or another life‐limiting fetal condition are: Pre‐Diagnosis, Learning the Diagnosis, Living With the Diagnosis, Birth and Death, and Post Death. As they navigate these stages, parents must also address 7 developmental tasks of pregnancy, which are (1) Navigating Relationships, (2) Comprehending Implications of the Condition, (3) Revising Goals of Pregnancy, (4) Making the Most of Time With Baby, (5) Preparing for Birth and Inevitable Death, (6) Advocating for Baby With Integrity, and (7) Adjusting to Life in Absence of Baby. Knowledgeable health care providers can do much more than support parents through grief and facilitate discussions about birth planning. This case report highlights the importance of a knowledgeable provider who can help parents navigate the stages and tasks of pregnancy, empowering them to make choices consistent with their values so they have no regrets.
Evaluation of expression of amino acid and fatty acid metabolic transporters in the placenta of pregnant women with glucose intolerance
Authors: Sakuragi Toshihide , Shibata Eiji , Yamamoto Megumi , Shimajiri Shohei , Kondo Emi , Mori Hiroshi , Tajiri Ryosuke , Nakayama Toshiyuki , Yoshino Kiyoshi , Tsuji Mayumi 
Published: November 2024

AbstractAimPregnant women with glucose intolerance often have large infants, even with strict glycemic control. We examined the expression of amino and fatty acid metabolic transporters in the placentas of such mothers to clarify the role of factors other than glucose transport resulting in giant infants.MethodsDeliveries at our hospital between 2017 and 2022 were assessed. Immunohistochemical staining of membrane transporters related to glucose, amino acid, and fatty acid transport was performed using postpartum placental tissue. Stained areas were classified and scored, and compared using the Mann–Whitney U test. Multiple logistic regression analysis was performed for large for gestational age infant as the outcome and maternal age, prepartum body mass index, primipara/multipara, gestational week, and glucose intolerance as confounding factors.ResultsAmong 1725 subjects, 101 met the inclusion criteria and were analyzed (glucose‐intolerant [GI] group, n = 61; non‐GI group, n = 40). Per unit villus, there was decreased expression of amino acid‐related transporters. However, per unit placenta, the immunohistochemical staining scores for glucose, amino acid, and fatty acid transport were significantly higher in the GI than in the non‐GI group. Multiple logistic regression analysis showed that L‐type amino acid transporter 1 (LAT1, odds ratio [95% confidence interval]: 12.35 [2.93–52.05], p < 0.001) and placenta‐plasma membrane fatty acid‐binding protein (placenta‐FABPpm, 6.27 [1.64–23.88], p = 0.007) were significantly higher in the GI than in the non‐GI group.ConclusionActivation of LAT1 and placenta‐FABPpm expressions observed in the placentas of glucose‐intolerant women despite glycemic control indicate that nutrients other than blood glucose should also be effectively managed.
Put me in coach: A daily examination of automated coaching on need for self‐knowledge and learning goal orientation through metacognitive activities
Authors: Dust Scott , Steed Laurens Bujold 
Published: November 2024

AbstractThe workplace coaching industry is growing through technology‐based applications that are designed to enhance coaching accessibility and scalability. Despite the increasing adoption of these technological innovations among practitioners, researchers have little understanding of the theoretical mechanisms by which these technologies impact coachees. Further, rigorous research examining the outcomes of these applications is lacking. This study focused specifically on automated coaching, a nascent but growing type of coaching program that allows users to access customized insights about themselves and their colleagues in a digital application. We applied objective self‐awareness theory to examine how engagement in an automated coaching platform facilitates self‐reflective processes on a day‐to‐day basis. In an experience sampling study of 84 employed users of an automated coaching platform, we found that engagement in automated coaching significantly increased metacognitive activities on a daily basis. Further, these effects spilled over, positively influencing the next‐day need for self‐knowledge and learning goal orientation. We discuss the theoretical and practical implications of these findings as they relate to workplace coaching.
Diagnosis of naturally‐occurring Cushing's syndrome by primary care veterinarians in selected European countries
Authors: Carvalho Miguel F. , Leal Rodolfo O. , Golinelli Stefania , Fracassi Federico , Arenas Carolina , Pérez‐Alenza Maria , Galac Sara , Mooney Carmel T. , Bennaim Michael 
Published: November 2024

AbstractBackgroundSeveral tests are available to diagnose naturally‐occurring Cushing's syndrome in dogs but there is a paucity of information on how primary care veterinarians (PCVs) use or interpret them.ObjectivesDetermine how PCVs from selected European countries diagnose Cushing's syndrome in dogs.MethodsCross‐sectional survey study assessing testing protocols used by PCVs for screening and differentiation of Cushing's syndrome.ResultsTwo thousand one hundred and seventy‐eight responses from 9 European countries were included. When Cushing's syndrome was suspected, 98.7% of respondents perform endocrine testing, whereas 1.2% rely on a treatment trial. Among the former, 59.9% reported performing screening tests in the absence of supportive clinical signs but with consistent clinicopathological abnormalities. Of 2150 respondents who performed endocrine testing, 66.6% report always using the same initial screening tests regardless of their pretest suspicion of disease. The tests most reported are the ACTH stimulation test (34.8%), low‐dose dexamethasone suppression test (LDDST; 30.4%) or a combination of different tests (25.2%). In the absence of financial constraint, 1419 (66.0%) respondents always attempted differentiation, using abdominal ultrasonography (81.0%) and LDDST (46.1%). Overall, 69.8% of respondents reported offering referral to a specialist in ≤20% of cases suspected or diagnosed with Cushing's syndrome over the previous 5 years.Conclusions and Clinical ImportanceTesting protocols vary among PCVs. Almost 60% of respondents potentially screen dogs without consistent clinical signs, raising concerns for overdiagnosis. A proportion never attempt differentiation, which likely affects prognosis. Cases are rarely referred to a specialist, reflecting that Cushing's syndrome is mainly managed in primary care practices. These results suggest that there is room for further education of PCVs.
Frequency and progression of azotemia during acute and chronic treatment of congestive heart failure in cats
Authors: Rogg Sarah , Mochel Jonathan P. , Kundu Debosmita , Tropf Melissa A. , Masters Allison K. , Adin Darcy B. , Ward Jessica L. 
Published: November 2024

AbstractBackgroundAzotemia is common in cats with congestive heart failure (CHF) and might be exacerbated by diuretic therapy.Hypothesis/ObjectivesDetermine frequency, risk factors, and survival impact of progressive azotemia in cats treated for CHF.AnimalsOne hundred and sixteen client‐owned cats with kidney function testing performed at least twice during acute or chronic CHF treatment.MethodsSerum creatinine (sCr) and electrolyte concentrations were determined at multiple clinical timepoints to detect azotemia and kidney injury (KI; sCr increase ≥0.3 mg/dL). Furosemide dosage between timepoints was calculated. Multivariable modeling was performed to identify predictors of KI, change in serum biochemistry results, and survival.ResultsAzotemia was common at all timepoints, including initial CHF diagnosis (44%). Kidney injury was documented in 66% of cats. Use of a furosemide continuous rate infusion was associated with increased risk of KI during hospitalization (odds ratio, 141.6; 95% confidence interval [CI], 12.1‐6233; P = .01). Higher furosemide dosage was associated with increase in sCr during hospitalization (P = .03) and at first reevaluation (P = .01). Treatment with an angiotensin converting enzyme inhibitor was associated with fewer lifetime KI events (P = .02). Age in years was the only variable associated with shorter survival (hazard ratio, 1.1; 95% CI, 1.0‐1.1; P = .03). Neither sCr nor KI were associated with long‐term outcome.Conclusions and Clinical ImportanceAzotemia and KI were common in cats during CHF treatment but did not impact survival.