bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of particulate matter on allergic respiratory diseases
Authors: Wu Jin‐Zhun , Ge Dan‐Dan , Zhou Lin‐Fu , Hou Ling‐Yun , Zhou Ying , Li Qi‐Yuan 
Published: June 2018

AbstractThe health impact of airborne particulate matter (PM) has long been a concern to clinicians, biologists, and the general public. With many epidemiological studies confirming the association of PM with allergic respiratory diseases, an increasing number of follow‐up empirical studies are being conducted to investigate the mechanisms underlying the toxic effects of PM on asthma and allergic rhinitis. In this review, we have briefly introduced the characteristics of PM and discussed its effects on public health. Subsequently, we have focused on recent studies to elucidate the association between PM and the allergic symptoms of human respiratory diseases. Specifically, we have discussed the mechanism of action of PM in allergic respiratory diseases according to different subtypes: coarse PM (PM2.5‐10), fine PM (PM2.5), and ultrafine PM.
Robotic rectal resection: preliminary Russian experience
Authors: Khatkov Igor , Pozdnyakov Stepan , Atroshchenko Andrey , Danilov Mikhail , Chudnikh Sergey , Abdulatipova Zaira , Dolgopyatov Igor , Saakjan Georgi , Streltsov Yuri , Yegorov Vladimir 
Published: June 2018

Abstract
Purpose To outline the preliminary experience of the da Vinci® robotic system used in a Moscow tertiary colorectal referral center for an unselected range of benign and malignant rectal conditions.
Methods Prospective non-randomized single-center study which analyzed results of 26 robotic rectal resections performed between january 2014 and december 2016.
Results The cohort included 10 females and 16 males (mean total age 61.6 years). Three patients underwent surgery for benign rectal villous adenomas. The median overall ASA score was 4 (ranged from 2 to 5). Of the surgeries, there were 19 total mesorectal excisions with 6 patients undergoing a multivisceral resection. The mean operating time was 358 minutes with a mean blood loss of 203 mL. All total mesorectal excision specimens were adjudged according Philip Quirke classification as mesorectal plane – Grade 3 with a mean of 18.5 lymph nodes identified (from 12 to 35). Of these there were 10 patients (38.5%) with lymph node metastases. After surgery the average pain score was 2.1 out of 10 on the “Visual-Analogue Pain Intensity Scale” and 1.5 score out of 10 on the “Brief Pain Inventory with Quality of Life”. Anal continency after rectal resection with total mesorectal excisions estimated according Wexner Scale: 10 days after surgery average score was −3.1 and a 6 month after surgery −1.6 score. The median length of hospital stay was 11 days (from 10 to 15).
Conclusion Our initial experience with a totally robotic rectal resection has shown the technique to be safe and feasible, particularly in patients where conventional laparoscopic rectal resection would be anticipated to be challenging.
COMMON SHOCK MODELS FOR CLAIM ARRAYS
Authors: Avanzi Benjamin , Taylor Greg , Wong Bernard 
Published: June 2018

AbstractThe paper is concerned with multiple claim arrays. In recognition of the extensive use by practitioners of large correlation matrices for the estimation of diversification benefits in capital modelling, we develop a methodology for the construction of such correlation structures (to any dimension). Indeed, the literature does not document any methodology by which practitioners, who often parameterise those correlations by means of informed guesswork, may do so in a disciplined and parsimonious manner.We construct a broad and flexible family of models, where dependency is induced by common shock components. Models incorporate dependencies between observations both within arrays and between arrays. Arrays are of general shape (possibly with holes), but include the usual cases of claim triangles and trapezia that appear in the literature. General forms of dependency are considered with cell-, row-, column-, diagonal-wise, and other forms of dependency as special cases. Substantial effort is applied to practical interpretation of such matrices generated by the models constructed here.Reasonably realistic examples are examined, in which an expression is obtained for the general entry in the correlation matrix in terms of a limited set of parameters, each of which has a straightforward intuitive meaning to the practitioner. This will maximise chance of obtaining a reliable matrix. This construction is illustrated by a numerical example.
Two-scalar turbulent Rayleigh–Bénard convection: numerical simulations and unifying theory
Authors: Yang Yantao , Verzicco Roberto , Lohse Detlef 
Published: June 2018

We conduct direct numerical simulations for turbulent Rayleigh–Bénard (RB) convection, driven simultaneously by two scalar components (say, temperature and concentration) with different molecular diffusivities, and measure the respective fluxes and the Reynolds number. To account for the results, we generalize the Grossmann–Lohse theory for traditional RB convection (Grossmann & Lohse, J. Fluid Mech., vol. 407, 2000, pp. 27–56; Phys. Rev. Lett., vol. 86 (15), 2001, pp. 3316–3319; Stevens et al., J. Fluid Mech., vol. 730, 2013, pp. 295–308) to this two-scalar turbulent convection. Our numerical results suggest that the generalized theory can successfully capture the overall trends for the fluxes of two scalars and the Reynolds number without introducing any new free parameters. In fact, for most of the parameter space explored here, the theory can even predict the absolute values of the fluxes and the Reynolds number with good accuracy. The current study extends the generality of the Grossmann–Lohse theory in the area of buoyancy-driven convection flows.
Effects of erythropoietin on body composition and fat–glucose metabolism in patients with affective disorders
Authors: Vinberg Maj , Højman Pernille , Pedersen Bente Klarlund , Kessing Lars Vedel , Miskowiak Kamilla W. 
Published: June 2018

AbstractBackgroundErythropoietin (EPO) has been suggested to improve metabolism and also cognition, but human studies are scarce. This randomised controlled trial aimed to investigate whether EPO treatment influences body composition and fat and glycated haemoglobin (HbA1c) and fasting glucose, and whether these changes would be associated with previous observed cognitive benefits of EPO.MethodIn total, 84 non-obese patients with treatment-resistant unipolar depression or bipolar disorder in remission were randomised to 8 weekly EPO (40,000 IU) or saline (NaCl 0.9%) infusions in a double-blind, parallel-group design. Patients underwent dual X-ray absorptiometry scans at baseline and week 14 (6 weeks after treatment completion). Cognitive measures were assessed and fasting levels of cholesterol, lipoprotein fractions, triacylglycerides, glucose and HbA1c were obtained at baseline, week 9 and follow-up week 14.ResultsIn total, 79 patients had complete pre- and post-treatment data (EPO:N=40, saline:N=39). EPO had no cumulative effect on body composition and markers of fat metabolism. The EPO-treated group exhibited significantly lower HbA1c levels after 8 weeks treatment [F(1, 80)=8.51,p=0.005], however, 6 weeks after treatment termination a significantly higher fasting glucose levels [F(1, 79)=5.85,p=0.02] and HbA1c levels [F(1, 79)=5.85,p=0.02] were seen. The latter increase in HbA1c was further significantly correlated with a better cognitive outcome on verbal memory (r=0.25,p=0.03).ConclusionRepeated EPO infusions had no cumulative effect on body composition in this cohort of patients with affective disorders, however, EPO modulated HbA1c and fasting glucose and this was associated with patients’ improvement of verbal memory.
The similarity of global value chains: A network-based measure
Authors: ZHU ZHEN , MORRISON GREG , PULIGA MICHELANGELO , CHESSA ALESSANDRO , RICCABONI MASSIMO 
Published: June 2018

AbstractInternational trade has been increasingly organized in the form of global value chains (GVCs). In this paper, we provide a new method for comparing GVCs across countries and over time. First, we use the World Input–Output Database (WIOD) to construct both the upstream and the downstream global value networks. Second, we introduce a network-based measure of node similarity to compare the GVCs between any pair of countries for each sector and each year available in the WIOD. Our network-based similarity is a better measure for node comparison than the existing ones because it takes into account all the direct and indirect relationships between the country–sector pairs, is applicable to both directed and weighted networks with self-loops, and takes into account externally defined node attributes. As a result, our measure of similarity reveals the most intensive interactions among the GVCs across countries and over time. From 1995 to 2011, the average similarity between sectors and countries have clear increasing trends, which are temporarily interrupted by the recent economic crisis. This measure of the similarity of GVCs provides quantitative answers to important questions about dependency, sustainability, risk, and competition in the global production system.
Adoption and Evaluation of a sample Pretreatment Protocol for Radiocarbon Dating of Cremated Bones at HEKAL
Authors: Major István , Dani János , Kiss Viktória , Melis Eszter , Patay Róbert , Szabó Géza , Hubay Katalin , Túri Marianna , Futó István , Huszánk Róbert , Jull A J Timothy , Molnár Mihály 
Published: June 2018

ABSTRACTA comparative study was undertaken to adopt and evaluate a radiocarbon (14C) preparation procedure for accelerator mass spectrometry (AMS) measurements of cremated bones at our laboratory, including different types of archaeological samples (cremated bone, bone, charcoal, charred grain). All 14C analyses were performed using the EnvironMICADAS AMS instrument at the Hertelendi Laboratory of Environmental Studies (HEKAL) and the ancillary analyses were also performed at the Institute for Nuclear Research (ATOMKI). After the physical and chemical cleaning of cremated bones, CO2 was extracted by acid hydrolysis followed by sealed-tube graphitization and 14C measurement. The supplementary δ13C measurements were also performed on CO2 gas while FTIR was measured on the powder fraction. Based on the FTIR and 14C analyses, our chemical pretreatment protocol was successful in removing contamination from the samples. Good reproducibility was obtained for the 0.2–0.3 mm fraction of blind-tested cremated samples and a maximum age difference of only 150 yr was found for the remaining case studies. This confirms the reliability of our procedure for 14C dating of cremated bones. However, in one case study, the age difference of 300 yr between two cremated fragments originating from the same urn shows that other processes affecting the cremated samples in the post-burial environment can substantially influence the 14C age, so caution must be exercised.
Curcumin attenuates hepatic fibrosis and insulin resistance induced by bile duct ligation in rats
Authors: Eshaghian Azam , Khodarahmi Ameneh , Safari Fatemeh , Binesh Fariba , Moradi Ali 
Published: June 2018

AbstractRecent studies have strongly indicated the hepatoprotective effect of curcumin; however, the precise mechanisms are not well understood. This study aimed to determine the protective effect of curcumin on hepatic damage and hepatic insulin resistance in biliary duct ligated (BDL) fibrotic rat model. To accomplish this, male Wistar rats were divided into four groups (eight for each): sham group, BDL group, sham+Cur group and BDL+Cur group. The last two groups received curcumin at a dose of 100 mg/kg daily for 4 weeks. The mRNA/protein expression levels of Ras-related C3 botulinum toxin substrate 1 (Rac1), Rac1-GTP, dinucleotide phosphate oxidase 1 (NOX1), signal transducer and activator of transcription 3 (STAT3), suppressor of cytokine signalling 3 (SOCS3), insulin receptor substrate 1 (IRS1), extracellular signal-regulated kinase 1 (ERK1), specific protein 1 (Sp1) and hypoxia-inducible factor-1α (HIF-1α) were measured by real-time PCR and Western blotting, respectively. Fasting blood glucose, insulin and Leptin levels were determined and homoeostasis model assessment-estimated insulin resistance, as an index of insulin resistance, was calculated. Curcumin significantly attenuated liver injury and fibrosis, including amelioration of liver histological changes, reduction of hepatic enzymes, as well as decreased expression of liver fibrogenesis-associated variables, including Rac1, Rac1-GTP, NOX1, ERK1, HIF-1α and Sp1. Curcumin also attenuated leptin level and insulin resistance, which had increased in BDL rats (P<0·05). Furthermore, compared with the BDL group, we observed an increase in IRS1 and a decrease in SOCS3 and STAT3 expression in the curcumin-treated BDL group (P<0·05), indicating return of these parameters towards normalcy. In conclusion, Curcumin showed hepatoprotective activity against BDL-induced liver injury and hepatic insulin resistance by influencing the expression of some genes/proteins involved in these processes, and the results suggest that it can be used as a therapeutic option.
‘That justice might not be infringed upon’: the judgement of God in the passion of Christ in Irenaeus of Lyons
Authors: Schendel Joshua 
Published: June 2018

AbstractSome recent scholarship has claimed Irenaeus as an early proponent of a non-violent atonement theory. In response, this essay argues that by tracing out tracing out the themes of the guilt of Adam and Eve, the justice and judgement of God, the passion of Christ, and their relations in the thought of Irenaeus of Lyons, it becomes evident that Irenaeus was not an early proponent of a non-violent atonement theory.
Radiation dominated implosion with nano-plasmonics
Authors: Csernai L.P. , Kroo N. , Papp I. 
Published: June 2018

AbstractInertial Confinement Fusion is a promising option to provide massive, clean, and affordable energy for mankind in the future. The present status of research and development is hindered by hydrodynamical instabilities occurring at the intense compression of the target fuel by energetic laser beams. A recent patent combines advances in two fields: Detonations in relativistic fluid dynamics (RFD) and radiative energy deposition by plasmonic nano-shells. The initial compression of the target pellet can be decreased, not to reach the Rayleigh–Taylor or other instabilities, and rapid volume ignition can be achieved by a final and more energetic laser pulse, which can be as short as the penetration time of the light across the pellet. The reflectivity of the target can be made negligible as in the present direct drive and indirect drive experiments, and the absorptivity can be increased by one or two orders of magnitude by plasmonic nano-shells embedded in the target fuel. Thus, higher ignition temperature and radiation dominated dynamics can be achieved with the limited initial compression. Here, we propose that a short final light pulse can heat the target so that most of the interior will reach the ignition temperature simultaneously based on the results of RFD. This makes the development of any kind of instability impossible, which would prevent complete ignition of the target.
Contrasting patterns of taxonomic, phylogenetic and functional variation along a Costa Rican altitudinal gradient in the plant family Melastomataceae
Authors: Kandlikar Gaurav S. , Vaz Marcel C. , Kriebel Ricardo , Vargas German , Michelangeli Fabián A. , Cordero Roberto , Almeda Frank , Avalos Gerardo , Fetcher Ned , Kraft Nathan J. B. 
Published: June 2018

Abstract:The functional composition of plant communities in montane regions has been studied for decades, and most recent analyses find that environmentally favourable landscapes at lower altitudes tend to be dominated by species with resource-acquisitive traits, while more resource-conservative taxa dominate higher-altitude communities. However, it is unclear the extent to which this pattern is driven by co-gradient variation within clades or changes in clade representation across the gradient. To test for co-gradient variation, species composition, phylogenetic structure and functional traits were quantified for 97 species within the plant family Melastomataceae at five locations across a 2500-m altitudinal gradient along Volcán Barva in Costa Rica. Average melastome leaf force to punch, specific leaf area and leaf size vary with altitude, while four other functional traits do not. Taxonomic dissimilarity between communities was correlated with altitudinal difference, while phylogenetic dissimilarity was correlated with altitudinal dissimilarity only when measured with a metric that emphasizes shallow turnover of the tips of the phylogeny. These results highlight how species turnover may be more pronounced than functional or phylogenetic variation along altitudinal gradients. In addition, these results highlight the conservation value of lowland tropical forests, which here harbour a disproportionate amount of phylogenetic and functional diversity.
Toward a Global Water Ethic: Learning from Indigenous Communities
Authors: Norman Emma S. 
Published: June 2018

AbstractThis review essay examines three important new contributions to the water governance literature, which provide important overviews of the changing water governance structures over time, and advance the call for a new water ethic. Furthering this work, I suggest that the need for a water ethic is globally important, but it is particularly urgent for indigenous communities. Settler expansion, fixed political boundaries, and subsequent colonial framings of land and water ownership have affected indigenous communities throughout the world and have led to severe environmental and social justice disparities. Although the books under consideration provide examples of indigenous rights associated with water protection, the theme is largely underdeveloped. Thus, I suggest that insights from indigenous communities’ more holistic and long-term relationship with water could help define and move forward the adoption of a new global water ethic. These insights are gleaned from work with indigenous communities throughout North America, particularly those in the Salish Sea and the Great Lakes regions. A new water ethic could incorporate three precepts: (1) treat water as sacred; (2) consider rights and responsibilities together; and (3) practice hydrophilia (love and know your waterways).
Addressing personal barriers to advance care planning: Qualitative investigation of a mindfulness-based intervention for adults with cancer and their family caregivers
Authors: Cottingham Ann H. , Beck-Coon Kathleen , Bernat Jennifer K. , Helft Paul R. , Schmidt Karen , Shields Cleveland G. , Torke Alexia M. , Johns Shelley A. 
Published: June 2018

AbstractObjectiveAdvance care planning (ACP) increases quality of life and satisfaction with care for those with cancer and their families, yet these important conversations often do not occur. Barriers include patients’ and families’ emotional responses to cancer, such as anxiety and sadness, which can lead to avoidance of discussing illness-related topics such as ACP. Interventions that address psychological barriers to ACP are needed. The purpose of this study was to explore the effects of a mindfulness intervention designed to cultivate patient and caregiver emotional and relational capacity to respond to the challenges of cancer with greater ease, potentially decreasing psychological barriers to ACP and enhancing ACP engagement.MethodThe Mindfully Optimizing Delivery of End-of-Life (MODEL) Care intervention provided 12 hours of experiential training to two cohorts of six to seven adults with advanced-stage cancer and their family caregivers (n = 13 dyads). Training included mindfulness practices, mindful communication skills development, and information about ACP. Patient and caregiver experiences of the MODEL Care program were assessed using semistructured interviews administered immediately postintervention and open-ended survey questions delivered immediately and at 4 weeks postintervention. Responses were analyzed using qualitative methods.ResultFour salient themes were identified. Patients and caregivers reported the intervention (1) enhanced adaptive coping practices, (2) lowered emotional reactivity, (3) strengthened relationships, and (4) improved communication, including communication about their disease.Significance of resultsThe MODEL Care intervention enhanced patient and caregiver capacity to respond to the emotional challenges that often accompany advanced cancer and decreased patient and caregiver psychological barriers to ACP.
Percy Grainger: How American was He?
Authors: Gillies Malcolm 
Published: June 2018

The national affiliation of composer-pianist Percy Grainger (1882–1961) is a complex matter. While often claimed today to have been Australian or American, he was a ‘naturally born British subject’ for the first 36 years of his life. Thereafter, he was a naturalized American. Drawing on Grainger’s letters, essays, scores and memorabilia, this article investigates the reasons behind Grainger’s adoption of American citizenship during the final months of the First World War, and the subsequent national traits within his manner of living as well as his social attitudes, musical approach and style. His contributions to instrumentation, scoring and texture, as well as to music education, are seen from this analysis to have strong American traits, and subsequent influence, while his compositional style remained essentially English, although built upon a technical base established while a teenage student in Germany.In later life, Grainger was ambivalent about remaining an American citizen and resident, not just because of an implied disloyalty to his ‘native land’, Australia, but also because of his lack of empathy with evolving American values. To a Yale University audience in 1921, he confessed to being ‘a cosmopolitan from first to last’. This article analyses Grainger’s thinking about cosmopolitanism, nationalism and universalism in the following decades, against the backdrop of his growing commitment to the racialist, later racist, cause of Nordicism. It focuses particularly upon Grainger’s series of articles about ‘Grieg: Nationalist and Cosmopolitan’ from 1943, before investigating the relationship between racial and national thinking in Grainger’s final years. This culminates in his last statement of musical ‘creed’, published in a Norwegian magazine in 1955: musically to support the ‘unity’ of the Nordic race, and to bring ‘honor and fame’ to his native land, Australia. Yet, Grainger died, in 1961, in America, and still an American citizen.
Un-signing Geneva: legal pragmatics in the management of asylum
Authors: de Leeuw Marc , van Wichelen Sonja 
Published: June 2018

AbstractIn the last decade, several states have increasingly tried to ‘un-sign’ to their humanitarian obligations by seeking ways to circumvent European or international law. Through an analysis of a recently passed act in Australia on the management of asylum seekers, this paper examines how the practice of ‘un-signing’ can be seen as a symptomatic instance of reconfiguring asylum in late modernity. We focus on the proliferation of ‘legal pragmatics’ in the management of refugees. By ‘legal pragmatics’, we refer to theprocessualways in which the state attempts to hollow out international refugee law and in which courts respond by reinstating it. Normative consequences are thecriminalisationand thejuridificationof refugees. We argue that the proliferation of ‘legal pragmatics’ illuminates not only the ever-expanding reach of neoliberal changes in domestic legislation, but also the limitations of human rights to adequately respond to the neoliberal vicissitudes of humanitarian government.