bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammation is a key contributor to ovarian cancer cell seeding
Authors: Jia Dongyu , Nagaoka Yoshiko , Katsumata Makoto , Orsulic Sandra 
Published: August 2018

AbstractThe incidence of ovarian cancer dramatically increases in early menopause but the factors contributing to cancer onset are unclear. Most ovarian cancers originate in the fallopian tube with subsequent implantation of malignant cells into the ovary. However, the events and conditions that lead to cancer cell implantation are unknown. To quantify which conditions are conducive to the seeding of cancer cells in an immunocompetent mouse model, we surgically implanted mouse ovarian cancer cells into the oviducts of syngeneic mice and simulated conditions associated with ovulatory wound repair, incessant ovulation, ovarian surface scarring, and aging. We found that the dominant site of cancer cell seeding was not the ovary but the nearby surgical wound site, which was associated with a strong and persistent inflammatory reaction. Conditions in the ovary associated with inflammation, such as acute ovulatory wound repair, active healing of the scarred ovarian surface, and mouse aging, contributed to increased seeding of the cancer cells to the surgical wound site and tissues surrounding the ovary. Changes in the ovary not accompanied by inflammation, such as completed ovulatory cycles and fully-healed scars on the ovarian surface, did not contribute to increased cancer cell seeding. We conclude that inflammation is the most likely mechanism by which ovulation and postmenopausal events contribute to the increased risk of ovarian cancer.
Development and Validation of the Computerised Adaptive Beat Alignment Test (CA-BAT)
Authors: Harrison Peter M. C. , Müllensiefen Daniel 
Published: August 2018

AbstractBeat perception is increasingly being recognised as a fundamental musical ability. A number of psychometric instruments have been developed to assess this ability, but these tests do not take advantage of modern psychometric techniques, and rarely receive systematic validation. The present research addresses this gap in the literature by developing and validating a new test, the Computerised Adaptive Beat Alignment Test (CA-BAT), a variant of the Beat Alignment Test (BAT) that leverages recent advances in psychometric theory, including item response theory, adaptive testing, and automatic item generation. The test is constructed and validated in four empirical studies. The results support the reliability and validity of the CA-BAT for laboratory testing, but suggest that the test is not well-suited to online testing, owing to its reliance on fine perceptual discrimination.
Assessing animal affect: an automated and self-initiated judgement bias task based on natural investigative behaviour
Authors: Jones Samantha , Neville Vikki , Higgs Laura , Paul Elizabeth S. , Dayan Peter , Robinson Emma S. J. , Mendl Michael 
Published: August 2018

AbstractScientific methods for assessing animal affect, especially affective valence (positivity or negativity), allow us to evaluate animal welfare and the effectiveness of 3Rs Refinements designed to improve wellbeing. Judgement bias tasks measure valence; however, task-training may be lengthy and/or require significant time from researchers. Here we develop an automated and self-initiated judgement bias task for rats which capitalises on their natural investigative behaviour. Rats insert their noses into a food trough to start trials. They then hear a tone and learn either to stay for 2 s to receive a food reward or to withdraw promptly to avoid an air-puff. Which contingency applies is signalled by two different tones. Judgement bias is measured by responses to intermediate ambiguous tones. In two experiments we show that rats learn the task in fewer sessions than other automated variants, generalise responses across ambiguous tones as expected, self-initiate 4–5 trials/min, and can be tested repeatedly. Affect manipulations generate main effect trends in the predicted directions, although not localised to ambiguous tones, so further construct validation is required. We also find that tone-reinforcer pairings and reinforcement or non-reinforcement of ambiguous trials can affect responses to ambiguity. This translatable task should facilitate more widespread uptake of judgement bias testing.
The threshold for the McGurk effect in audio-visual noise decreases with development
Authors: Hirst Rebecca J. , Stacey Jemaine E. , Cragg Lucy , Stacey Paula C. , Allen Harriet A. 
Published: August 2018

AbstractAcross development, vision increasingly influences audio-visual perception. This is evidenced in illusions such as the McGurk effect, in which a seen mouth movement changes the perceived sound. The current paper assessed the effects of manipulating the clarity of the heard and seen signal upon the McGurk effect in children aged 3–6 (n = 29), 7–9 (n = 32) and 10–12 (n = 29) years, and adults aged 20–35 years (n = 32). Auditory noise increased, and visual blur decreased, the likelihood of vision changing auditory perception. Based upon a proposed developmental shift from auditory to visual dominance we predicted that younger children would be less susceptible to McGurk responses, and that adults would continue to be influenced by vision in higher levels of visual noise and with less auditory noise. Susceptibility to the McGurk effect was higher in adults compared with 3–6-year-olds and 7–9-year-olds but not 10–12-year-olds. Younger children required more auditory noise, and less visual noise, than adults to induce McGurk responses (i.e. adults and older children were more easily influenced by vision). Reduced susceptibility in childhood supports the theory that sensory dominance shifts across development and reaches adult-like levels by 10 years of age.
Accelerated triacylglycerol production without growth inhibition by overexpression of a glycerol-3-phosphate acyltransferase in the unicellular red alga Cyanidioschyzon merolae
Authors: Fukuda Satoshi , Hirasawa Eri , Takemura Tokiaki , Takahashi Sota , Chokshi Kaumeel , Pancha Imran , Tanaka Kan , Imamura Sousuke 
Published: August 2018

AbstractMicroalgae accumulate triacylglycerols (TAGs), a promising feedstock for biodiesel production, under unfavorable environmental or stress conditions for their growth. Our previous analyses revealed that only transcripts of CmGPAT1 and CmGPAT2, both encoding glycerol-3-phosphate acyltransferase, were increased among fatty acid and TAG synthesis genes under TAG accumulation conditions in the red alga Cyanidioschyzon merolae. In this study, to investigate the role of these proteins in TAG accumulation in C. merolae, we constructed FLAG-fused CmGPAT1 and CmGPAT2 overexpression strains. We found that CmGPAT1 overexpression resulted in marked accumulation of TAG even under normal growth conditions, with the maximum TAG productivity increased 56.1-fold compared with the control strain, without a negative impact on algal growth. The relative fatty acid composition of 18:2 in the TAGs and the sn−1/sn−3 positions were significantly increased compared with the control strain, suggesting that CmGPAT1 had a substrate preference for 18:2. Immunoblot analysis after cell fractionation and immunostaining analysis demonstrated that CmGPAT1 localizes in the endoplasmic reticulum (ER). These results indicate that the reaction catalyzed by the ER-localized CmGPAT1 is a rate-limiting step for TAG synthesis in C. merolae, and would be a potential target for improvement of TAG productivity in microalgae.
Self-healing effects in a semi-ordered liquid for stable electronic conversion of high-energy radiation
Authors: Nullmeyer Bradley R. , Kwon Jae W. , Robertson J. David , Garnov Alexander Y. 
Published: August 2018

AbstractRadiation damage in solid-state semiconductors has, until now, placed strict limitations on the acceptable decay energies of radioisotopes in radiovoltaic cells. Relegation to low-energy beta-emitting isotopes has minimized the power output from these devices and limited the technology’s ability to deliver greater energy densities and longer lifetimes than conventional batteries. We demonstrate the self-healing abilities of a liquid-phase semiconducting alloy which can withstand high-energy alpha radiation. Neutron diffraction of liquid selenium-sulfur shows the liquid phase repairing damage sustained in the irradiation of the solid phase. This self-healing behavior results in long-lived power output in a liquid selenium-sulfur alphavoltaic cell. To the best of our knowledge, this marks the only successful demonstration of resistance to high-energy radiation (>500 keV) in a semiconducting material. This new robustness can potentially allow increases to the available energy density in radiovoltaic cells near 1000 times the current state of the art.
Preattentive and Predictive Processing of Visual Motion
Authors: Schmitt Constanze , Klingenhoefer Steffen , Bremmer Frank 
Published: August 2018

AbstractInteraction with the environment requires fast and reliable sensory processing. The visual system is confronted with a continuous flow of high-dimensional input (e.g. orientation, color, motion). From a theoretical point of view, it would be advantageous if critical information was processed independent of attentional load, i.e. preattentively. Here, we hypothesized that visual motion is such a critical signal and aimed for a neural signature of its preattentive encoding. Furthermore, we were interested in the neural correlates of predictability of linear motion trajectories based on the presence or absence of preceding motion. We presented a visual oddball paradigm and studied event-related potentials (ERPs). Stimuli were linearly moving Gabor patches that disappeared behind an occluder. The difference between deviant and standard trials was a trajectory change which happened behind the occluder in deviant trials only, inducing a prediction error. As hypothesized, we found a visual mismatch negativity-component over parietal and occipital electrodes. In a further condition, trials without preceding motion were presented in which the patch just appeared from behind the occluder and, hence, was not predictable. We found larger ERP-components for unpredictable stimuli. In summary, our results provide evidence for a preattentive and predictive processing of linear trajectories of visual motion.
Magnetic order and disorder in nanomagnets probed by superconducting vortices
Authors: Rollano V. , del Valle J. , Gomez A. , Velez M. , Alvarez-Prado L. M. , Quiros C. , Martin J. I. , Osorio M. R. , Granados D. , Gonzalez E. M. , Vicent J. L. 
Published: August 2018

AbstractWe have studied two nanomagnet systems with strong (Co/Pd multilayers) and weak (NdCo alloy films) stray magnetic fields by probing the out-of-plane magnetic states with superconducting vortices. The hybrid samples are made of array of nanomagnets embedded in superconducting Nb thin films. The vortex motion detects relevant magnetic state features, since superconducting vortices are able to discriminate between different magnetic stray field strengths and directions. The usual matching effect between the superconducting vortex lattice and the periodic pinning array can be quenched by means of disorder magnetic potentials with strong stray fields at random. Ordered stray fields retrieve the matching effect and yield asymmetry and shift in the vortex dissipation signal. Furthermore vortices can discriminate the sizes of the nanomagnet magnetic domains, detecting magnetic domain sizes as small as 70 nm. In addition, we observe that the vortex cores play the crucial role instead of the supercurrents around the vortex.
Carbon fiber doped thermosetting elastomer for flexible sensors: physical properties and microfabrication
Authors: Khosla Ajit , Shah Shreyas , Shiblee MD Nahin Islam , Mir Sajjad Husain , Nagahara Larry Akio , Thundat Thomas , Shekar Praveen Kumar , Kawakami Masaru , Furukawa Hidemitsu 
Published: August 2018

AbstractWe have developed conductive microstructures using micropatternable and conductive hybrid nanocomposite polymer. In this method carbon fibers (CFs) were blended into polydimethylsiloxane (PDMS). Electrical conductivities of different compositions were investigated with various fiber lengths (50–250 μm), and weight percentages (wt%) (10–60 wt%). Sample composites of 2 cm × 1 cm × 500 μm were fabricated for 4-point probe conductivity measurements. The measured percolation thresholds varied with length of the fibers: 50 wt% (307.7 S/m) for 50 µm, 40 wt% (851.1 S/m) for 150 µm, and 30 wt% (769.23 S/m) for 250 μm fibers. The conductive composites showed higher elastic modulus when compared to that of PDMS.
Co3O4/carbon composite nanofibrous membrane enabled high-efficiency electromagnetic wave absorption
Authors: Abdalla Ibrahim , Shen Jiali , Yu Jianyong , Li Zhaoling , Ding Bin 
Published: August 2018

AbstractElectromagnetic (EM) wave absorbing materials have been fabricated from diverse materials such as conductive polymers, carbon based nanostructures and magnetic metal oxides. Nevertheless, it has remained a great challenge to develop lightweight and high-efficiency EM wave absorbing materials with a broad frequency range. Herein, we report a scalable strategy to create Co3O4/carbon composite nanofibrous membrane by electrospinning technique followed by stabilization and carbonization processes. An optimal reflection loss (RL) value of 36.27 dB is reached at 13.76 GHz for a layer of 2 mm thickness. RL exceeding −20 dB can be realized in any interval within the 4.5–14.4 GHz range by selecting a proper thickness of the absorbing layer between 1 and 5 mm. The Co3O4/carbon composite nanofibrous membrane could be well served as promising and attractive candidates for lightweight and enhanced EM wave absorbing materials. This presented research provides an innovative and effective approach to design the novel EM wave absorbing material in a broad frequency range for practical applications.
Expression profiling in a mammalian host reveals the strong induction of genes encoding LysM domain-containing proteins in Enterococcus faecium
Authors: Cacaci Margherita , Giraud Caroline , Leger Loic , Torelli Riccardo , Martini Cecilia , Posteraro Brunella , Palmieri Valentina , Sanguinetti Maurizio , Bugli Francesca , Hartke Axel 
Published: August 2018

AbstractEnterococcus faecium is an important health care-associated pathogen that is difficult to treat due to the high level of antibiotic resistance of clinical isolates. The identification of new potential therapeutic targets or vaccination strategies is therefore urgently needed. In this regard, we carried out a transcriptomic analysis of the E. faecium vancomycin-resistant strain AUS0004, comparing the gene expression of bacteria grown under laboratory conditions and bacteria isolated from an infection site. This analysis highlighted more than 360 genes potentially induced under infection conditions. Owing to their expression profiles, four LysM domain-containing proteins were characterized in more detail. The EFAU004_01059, 1150 and 494 proteins are highly homologous, whereas EFAU004_01209 has a unique domain-architecture and sequence. The analysis of corresponding mutants showed that all LysM proteins played relevant roles in the infection process of E. faecium in mice. The EFAU004_01209 mutant also displayed profound morphological modifications, suggesting it has a role in cell wall synthesis or cell division. Furthermore, the adhesion to kidney cells and growth of the mutant was affected in human urine. All these phenotypes and the surface exposure of EFAU004_01209 identify this protein as an interesting new drug target in E. faecium.
Tinnitus Suppression in Cochlear Implant Patients Using a Sound Therapy App
Authors: Tyler Richard S. , Owen Rachael L. , Bridges Julie , Gander Phillip E. , Perreau Ann , Mancini Patricia C. 
Published: August 2018

PurposeThe use of acoustic stimuli to reduce the prominence of tinnitus has been used for decades. Counseling and tinnitus sound therapy options are not currently widespread for cochlear implant (CI) users. The goal of this study was to determine whether tinnitus therapy sounds created for individuals with acoustic hearing may also benefit CI users.MethodSixteen sounds from the ReSound Relief app (Version 3.0) were selected for the study. Sixteen participants were asked to rate the overall acceptability of each sound and to write the description of the sound they perceived. Sounds were streamed from an Apple™ iPod (6th generation) to the CI using a Cochlear™ Wireless Mini Microphone 2+. Thirteen participants then completed a 5-min trial where they rated their pretrial and posttrial tinnitus and the acceptability of a subset of preferred sounds. Ten out of these 13 participants completed a 2-week home trial with a preferred sound after which they answered an online tinnitus questionnaire and rated the effectiveness of the sound therapy.ResultsIndividual differences were large. Results from the 5-min trial showed that sounds perceived as rain, music, and waves were rated the most acceptable. For all of the participants, the posttrial tinnitus loudness rating was lower than the pretrial rating, with some participants experiencing greater difference in their tinnitus loudness than others. At the end of the 2-week home trial, 3 of 10 participants rated the effectiveness of sound therapy 70% or higher.ConclusionThe results suggest that the use of tinnitus therapy sounds delivered through a CI can be acceptable and provides relief for some tinnitus sufferers.
The Cepheid period–luminosity–metallicity relation based on Gaia DR2 data
Authors: Groenewegen M. A. T. 
Published: August 2018

Aims. We use parallax data from the Gaia second data release (GDR2), combined with parallax data based on HIPPARCOS and HST data, to derive the period–luminosity–metallicity (PLZ) relation for Galactic classical cepheids (CCs) in the V, K, and Wesenheit WVK bands.
Methods. An initial sample of 452 CCs are extracted from the literature with spectroscopically derived iron abundances. Reddening values, classifications, pulsation periods, and mean V- and K-band magnitudes are taken from the literature. Based on nine CCs with a goodness-of-fit (GOF) statistic smaller than 8 and with an accurate non-Gaia parallax (σπ comparable to that in GDR2), a parallax zero-point offset of −0.049 ± 0.018 mas is derived. Selecting a GOF statistic smaller than 8 removes about 40% of the sample most likely related due to binarity. Excluding first overtone and multi-mode cepheids and applying some other criteria reduces the sample to about 200 stars.
Results. The derived PL(Z) relations depend strongly on the parallax zero-point offset. The slope of the PL relation is found to be different from the relations in the LMC at the 3σ level. Fixing the slope to the value found in the LMC leads to a distance modulus (DM) to the LMC of order 18.7 mag, larger than the canonical distance. The canonical DM of around 18.5 mag would require a parallax zero-point offset of order −0.1 mas. Given the strong correlation between zero point, period and metallicity dependence of the PL relation, and the parallax zero-point offset there is no evidence for a metallicity term in the PLZ relation.
Conclusions. The GDR2 release does not allow us to improve on the current distance scale based on CCs. The value of and the uncertainty on the parallax zero-point offset leads to uncertainties of order 0.15 mag on the distance scale. The parallax zero-point offset will need to be known at a level of 3 μas or better to have a 0.01 mag or smaller effect on the zero point of the PL relation and the DM to the LMC.
Complications of Volar Plating of Distal Radius Fractures: A Systematic Review
Authors: Alter Todd H. , Sandrowski Kristin , Gallant Gregory , Kwok Moody , Ilyas Asif M. 
Published: August 2018

Background In recent years, there has been an increased utilization of volar locking plate fixation of distal radius fractures (DRFs). However, reported long-term complication rates with this technique remain unclear.
Purpose The purpose of this systematic review was to investigate the pooled incidence of complications associated with volar locking plating of DRF.
Methods A search of the Scopus database was performed from 2006 through 2016. Studies were considered eligible if they had a diagnosis of a DRF and were treated with a volar locking plate with an average of 12 months or longer follow-up.
Results The literature search yielded 633 citations, with 55 eligible for inclusion in the review (total n = 3,911). An overall complication rate of 15% was identified, with 5% representing major complications requiring reoperation. The most common complication types identified included nerve dysfunction (5.7%), tendon injury (3.5%), and hardware-related issues (1.6%).
Conclusion Nerve complications were reportedly higher than tendon and hardware-related complications combined. However, despite varying complication rates in the literature, this systematic review reveals an overall low complication rate associated with volar locking plating of DRF.
Cost Analysis of Azithromycin versus Erythromycin in Pregnancies Complicated by Preterm Premature Rupture of Membranes
Authors: Smith Devin , Buhimschi Catalin , Finneran Matthew 
Published: August 2018

Objective To quantify the potential cost savings if azithromycin is substituted for erythromycin in women with preterm premature rupture of membranes (PPROM).
Study Design Secondary analysis of a multicentered study investigating magnesium sulfate for the prevention of cerebral palsy in premature infants. All patients with PPROM who received antibiotics for prophylaxis were included in the analysis. The number of expected doses each patient would have received was calculated for erythromycin, multidose azithromycin, and single-dose azithromycin regimens accounting for latency from PPROM to delivery. The wholesale acquisition cost was used to calculate the expected cost of each regimen.
Results There were 981 PPROM patients who received a penicillin class antibiotic and erythromycin. Patients would have received 7,528 intravenous doses and 10,194 oral doses of erythromycin at a combined cost of $357,169. In comparison, patients would have received 6,422 and 3,942 doses at a cost of $15,669 and $9,574 for the multidose and single-dose azithromycin regimens respectively, which represents a more than 95% cost reduction for either regimen compared with erythromycin.
Conclusion The use of azithromycin substituted for erythromycin in the standard antibiotic regimen of women with PPROM represents a potential for substantial cost reduction.