bluuebunny/crossref_metadata_2025_split huggingface dataset:
False signals induced by single-cell imputation
Authors: Andrews Tallulah S. , Hemberg Martin 
Published: November 2018

Background: Single-cell RNASeq is a powerful tool for measuring gene expression at the resolution of individual cells. A significant challenge in the analysis of this data is the large amount of zero values, representing either missing data or no expression. Several imputation approaches have been proposed to deal with this issue, but since these methods generally rely on structure inherent to the dataset under consideration they may not provide any additional information. Methods: We evaluated the risk of generating false positive or irreproducible results when imputing data with five different methods. We applied each method to a variety of simulated datasets as well as to permuted real single-cell RNASeq datasets and consider the number of false positive gene-gene correlations and differentially expressed genes. Using matched 10X Chromium and Smartseq2 data from the Tabula Muris database we examined the reproducibility of markers before and after imputation. Results: The extent of false-positive signals introduced by imputation varied considerably by method. Data smoothing based methods, MAGIC and knn-smooth, generated a very high number of false-positives in both real and simulated data. Model-based imputation methods typically generated fewer false-positives but this varied greatly depending on how well datasets conformed to the underlying model. Furthermore, only SAVER exhibited reproducibility comparable to unimputed data across matched data. Conclusions: Imputation of single-cell RNASeq data introduces circularity that can generate false-positive results. Thus, statistical tests applied to imputed data should be treated with care. Additional filtering by effect size can reduce but not fully eliminate these effects. Of the methods we considered, SAVER was the least likely to generate false or irreproducible results, thus should be favoured over alternatives if imputation is necessary.
The Microstructural Investigation of Vermiculite-Infiltrated Electron Beam Physical Vapor Deposition Thermal Barrier Coatings
Authors: Ozgurluk Yasin , Doleker Kadir Mert , Ahlatci Hayrettin , Ozkan Dervis , Karaoglanli Abdullah Cahit 
Published: November 2018

Abstract
Thermal barrier coatings (TBCs) are widely used in aerospace and aviation industries for materials required to withstand severe environments such as oxidation, hot-corrosion failure and CMAS (calcia–magnesia–alumina–silica) attack or vermiculite corrosion. This is particularly apparent in vermiculite, which can penetrate sand, volcanic ash and is the most destructive damage mechanism in the TBC system. Impurities from the desert environment such as calcia–magnesia–alumina–silica (CMAS) cause degradation of TBCs. In this research, CoNiCrAlY metallic bond coatings were deposited on Inconel 718 nickel based superalloy substrates with a thickness of around 100 μm using a Cold Gas Dynamic Spray (CGDS) technique. Production of TBCs were carried out with deposition of YSZ ceramic top coating material using Electron Beam Physical Vapor Deposition (EB-PVD), with a thickness of around 200 μm. The effect of CMAS with spreading naturally-occurring mineral (vermiculite) on TBC samples were investigated using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) analysis and X-ray diffraction (XRD). The microstructure evolution of YSZ and failure mechanism of TBC were evaluated.
„Wer sich aber zum Wurm macht …“ – Würde als Selbstverpflichtung
Authors: Bauer Katharina 
Published: November 2018

AbstractKant introduces a duty to oneself to respect oneself and to avoid servility – or notto make oneself a worm. I argue for a wider understanding of this duty: Persons ought to respect their own dignity as persons with autonomy, rationality, and morality (A), but also as personalities, who embody dignity and live a dignified life (B). A corresponds to Kant’s concept of duty as the necessity of an action done out of respect for the moral law, B is an obligation arising from the practical necessity that follows from one’s self-understanding as an individual personality in a socio-cultural context. A and B relate to two types of dignity that are discussed in current debates. I argue that both types of dignity are equally relevant for understanding and respecting one’s own dignity. Finally I discuss why, even though persons can behave like worms, others ought not to step on them.
Sollen und Wollen
Authors: Freitag Wolfgang 
Published: November 2018

Abstract
The paper explores the ontology of ‚ought‘ (Sollen) by analyzing ought-sentences (Sollsätze). It claims that ought-sentences are pragmatically ambiguous between a prescriptive and a descriptive reading, and argues that there is a close connection between the function of prescriptive ought-sentences and the truth conditions of descriptive ought-sentences. More precisely, the paper contends that the truth conditions of descriptive ought-sentences, and thereby oughtness itself, is grounded in desire (Wollen).
Philosophische Praxis für persönliche fragen
Authors: Mühl Martin 
Published: November 2018

Abstract
The claim, renewed some years ago, of being able to advise on personal questions of life seems to bring philosophy into a fundamental conflict with its other claim of promoting human self-determination. However, the conflict only arises if philosophy does not sufficiently distinguish between the social orientation of self-determination towards universality and the subjective orientation of action execution. This is the case both in subjectivist mentalism and in the tradition of philosophy of language. The insufficient distinction prevents philosophy not only from being able to be helpful in the case of action but also from adequately explaining its object, the human orientation of validity. Plessner clarifies the basis of the practical distinction between social validity and subjective action orientation. Against this background we can better understand Socrates’ and Wittgenstein’s views on how philosophy must proceed in discourse if it is to provide assistance in personal questions without paternalism.
The trends in the main thalweg path of selected reaches of the Middle Vistula River, and their relationships to the geological structure of river channel zone
Authors: Falkowski Tomasz , Ostrowski Piotr , Bogucki Marek , Karczmarz Dariusz 
Published: November 2018

Abstract
Research carried out by the authors’ team in the valleys of many rivers in the Polish Lowlands has shown that the contemporary morphodynamics of channel zones is highly influenced by protrusions of erosion-resistant sub-alluvial bedrock. The article presents the results of analysis of two reaches of the Middle Vistula: near Solec nad Wisłą (km 330-340) and Gołąb (km 382-388), where such protrusions have been found. At each of them, two series of bathymetric measurements were carried out during medium and low water levels in the river channel. The measurements were made using hydrographic sets integrated with a GNSS receiver. The first series of measurements was carried out in July 2004, and the second one in September 2016. In parallel with the bathymetric surveys, low-altitude aerial photographs were taken in 2016 to document the morphology of the channel zone and the condition of the river engineering structures. A comparison of the obtained bathymetric maps shows a high correspondence between the thalweg line from 2004 and that observed twelve years later. This phenomenon proves the significance of the bedrock relief beneath the modern alluvial deposits for the water flow process in the channel. The relief causes the flow to concentrate in specific zones so strongly that it contributes to the damage of river engineering structures that put limits on the channel processes. This trend of concentrating the main thalweg is also accompanied by the diversity of depositional environments of river channel facies, identified along the studied reaches.
Lithostratigraphic Classification Method Combining Optimal Texture Window Size Selection and Test Sample Purification Using Landsat 8 OLI Data
Authors: Qiu Yufang , Ming Dongping 
Published: November 2018

Abstract
Gray Level Co-Occurrence Matrix (GLCM), as a measure of spatial features has been used as supplemental information to improve image classification accuracy for lithological recognition. Window size is an important parameter for texture extraction, which will affect the extracted texture results. Besides, the existence of mixed pixels in image usually causes errors in test samples, which significantly influences the credibility of accuracy assessment. Thus, this paper proposes a lithological classification method combined with optimal texture window size selection and test sample purification. Firstly, optimal window size pre-estimated based on semivariogram was used to calculated GLCM texture of image. Secondly, based on multidimensional textural and spectral features, a support vector machine (SVM) classifier was employed to classify the image. Thirdly, using the proposed sample purification method and textural features of image, sample purification rules were created based on attribute coherence to remove the test sample points that conflicted with the rules. Finally, the validity of the semivariogram-based texture extraction window selection was verified by classifications based on Angular Second Moment (ASM) of different window sizes combined with spectral features. Also, the accuracies between different combinations of classifications were assessed by test samples with and without sample purification. Experimental results show that the pre-estimated texture window size can guarantee a classification result with high classification accuracy for lithological classification. The results also demonstrated that the accuracy of lithological classification based on spectral features and ASM textural features was the highest. The overall lithological classification accuracy and kappa value, without sample purification selected by stratified sampling, were respectively 87.4% and 0.84, however those with sample purification were respectively 88.01% and 0.85. The results show that the proposed method is capable of yielding more reliable lithostratigraphic identification.
The evaluation of geosites in the territory of National park „Kopaonik“(Serbia)
Authors: Vukoičić Danijela , Milosavljević Saša , Valjarević Aleksandar , Nikolić Milena , Srećković-Batoćanin Danica 
Published: November 2018

AbstractIn the relatively small area of the National Park (NP) „Kopaonik“ a lot of exogenous and endogenous processes took part and continue to act until present day. In this paper are presented the geotouristic resources evaluation results for six geosites in the NP „Kopaonik“. The experts on this field gave their assessment in three versions. The first one is concerned with the evaluation of the educative contents, the second one is concerned with the evaluation of geotouristic values, while the third version, which is based on the Modified Geosite Assessment Model (M-GAM) offers the assessment regarding education, aesthetic significance, protection, functional and touristic values. The M-GAM method takes in consideration the opinion of visitors along with the estimation of subindicators given by experts, on whom relies the previous two versions. The include of visitors in the evaluation process leads to more objective estimations. Results obtained by this study can be useful for the improvement and planning of touristic activities on geosites because, bearing in mind their significance for the tourists, they indicate on the lower values that require more attention in the future.
Development and Experimental Evaluation of Leakage Current Measurement Sensor for Electrical Power Apparatus
Authors: Rao Mandava Mohana , Kumar Mritunjay , L Archana 
Published: November 2018

Abstract
Leakage current measurement plays an important role in determining the healthiness of high voltage insulation of a power apparatus. High voltage (HV) insulation degrades due to electrical, thermal and mechanical ageing and their cumulative effects, and thus the leakage current of the insulation increase over a period of time. The accurate and real time measurement of leakage current enables the utilities to on-line access the healthiness of the insulation. This paper describes about the design, development, calibration and testing of a novel non-contact type passive leakage current sensor which can be used for monitoring of various electrical devices based on the analysis of the leakage current captured by the sensor. The developed sensor has been successfully used for measurement of leakage current in oil-filled HV bushings as well as in gas insulated surge arresters. The sensitivity of the developed sensor as per its design can be in the order of few milli amperes in case of bushing and in the order few micro amperes for surge arrester monitoring. The paper also reported a novel design of bushing adapter-sensor assembly for on-line measuring the leakage current in HV bushings without using the conventional capacitive or resistive tapping based measurements. Further, results covering experimental leakage current measurement on a 420 kV bushing using the developed adapter sensor assembly have also been presented. To establish capabilities of the developed sensor with optimized design parameters, laboratory measurements of leakage current on 420 kV and 145 kV GIS surge arresters have also been carried out and reported in the paper. Third harmonic content of surge arrester leakage current has also been estimated in-line with IEC requirement to assess the healthiness of the surge arrester. Finally, suitability of the developed sensor for leakage current measurement of above power apparatus equipment has also been analyzed and discussed.
Teaching Diagnostic Reasoning: A Review of Evidence-Based Interventions
Authors: Burt Leah , Corbridge Susan 
Published: November 2018

AbstractProblem/Background: The ability to accurately diagnose patients based on symptom profiles is a vital yet challenging skill that Nurse Practitioners (NPs) undertake frequently. Purpose: This integrative literature review highlights a variety of evidence based, practical educational strategies that foster the development of diagnostic reasoning. Methods: An integrative literature review was conducted in order to identify original research focusing on diagnostic reasoning educational interventions. Results: Eighteen primary sources met inclusion and exclusion criteria. Results are synthesized in terms of sample and setting, methodological features, interventions, and outcomes. Interventions broadly fit into five educational themes: testing strategies, cognitive biases, simulation programs, course formats, and instructional approaches. Discussion: Interventions are simple and can be implemented in multiple educational settings. Future research should occur in populations of NP students. Validated, easy-to-use measurement tools as well as more precise diagnostic reasoning concept development should occur.
Weak group inverse
Authors: Wang Hongxing , Chen Jianlong 
Published: November 2018

AbstractIn this paper, we introduce the weak group inverse (called as the WG inverse in the present paper) for square complex matrices of an arbitrary index, and give some of its characterizations and properties. Furthermore, we introduce two orders: one is a pre-order and the other is a partial order, and derive several characterizations of the two orders. The paper ends with a characterization of the core EP order using WG inverses.
Fast tetrahedral mesh generation and segmentation of an atlas-based heart model using a periodic uniform grid
Authors: Vasilev Eugene , Lachinov Dmitry , Grishin Anton , Turlapov Vadim 
Published: November 2018

Abstract
A fast procedure for generation of regular tetrahedral finite element mesh for objects with complex shape cavities is proposed. The procedure like LBIE-Mesher can generate tetrahedral meshes for the volume interior to a polygonal surface, or for an interval volume between two surfaces having a complex shape and defined in STL-format. This procedure consists of several stages: generation of a regular tetrahedral mesh that fills the volume of the required object; generation of clipping for the uniform grid parts by a boundary surface; shifting vertices of the boundary layer to align onto the surface.We present a sequential and parallel implementation of the algorithm and compare their performance with existing generators of tetrahedral grids such as TetGen, NETGEN, and CGAL. The current version of the algorithm using the mobile GPU is about 5 times faster than NETGEN. The source code of the developed software is available on GitHub.
Mean-Variance QTL Mapping Identifies Novel QTL for Circadian Activity and Exploratory Behavior in Mice
Authors: Corty Robert W , Kumar Vivek , Tarantino Lisa M , Takahashi Joseph S , Valdar William 
Published: November 2018

AbstractWe illustrate, through two case studies, that “mean-variance QTL mapping”—QTL mapping that models effects on the mean and the variance simultaneously—can discover QTL that traditional interval mapping cannot. Mean-variance QTL mapping is based on the double generalized linear model, which extends the standard linear model used in interval mapping by incorporating not only a set of genetic and covariate effects for mean but also set of such effects for the residual variance. Its potential for use in QTL mapping has been described previously, but it remains underutilized, with certain key advantages undemonstrated until now. In the first case study, a reduced complexity intercross of C57BL/6J and C57BL/6N mice examining circadian behavior, our reanalysis detected a mean-controlling QTL for circadian wheel running activity that interval mapping did not; mean-variance QTL mapping was more powerful than interval mapping at the QTL because it accounted for the fact that mice homozygous for the C57BL/6N allele had less residual variance than other mice. In the second case study, an intercross between C57BL/6J and C58/J mice examining anxiety-like behaviors, our reanalysis detected a variance-controlling QTL for rearing behavior; interval mapping did not identify this QTL because it does not target variance QTL. We believe that the results of these reanalyses, which in other respects largely replicated the original findings, support the use of mean-variance QTL mapping as standard practice.
QTL Mapping on a Background of Variance Heterogeneity
Authors: Corty Robert W , Valdar William 
Published: November 2018

AbstractStandard QTL mapping procedures seek to identify genetic loci affecting the phenotypic mean while assuming that all individuals have the same residual variance. But when the residual variance differs systematically between groups, perhaps due to a genetic or environmental factor, such standard procedures can falter: in testing for QTL associations, they attribute too much weight to observations that are noisy and too little to those that are precise, resulting in reduced power and and increased susceptibility to false positives. The negative effects of such “background variance heterogeneity” (BVH) on standard QTL mapping have received little attention until now, although the subject is closely related to work on the detection of variance-controlling genes. Here we use simulation to examine how BVH affects power and false positive rate for detecting QTL affecting the mean (mQTL), the variance (vQTL), or both (mvQTL). We compare linear regression for mQTL and Levene’s test for vQTL, with tests more recently developed, including tests based on the double generalized linear model (DGLM), which can model BVH explicitly. We show that, when used in conjunction with a suitable permutation procedure, the DGLM-based tests accurately control false positive rate and are more powerful than the other tests. We also find that some adverse effects of BVH can be mitigated by applying a rank inverse normal transform. We apply our novel approach, which we term “mean-variance QTL mapping”, to publicly available data on a mouse backcross and, after accommodating BVH driven by sire, detect a new mQTL for bodyweight.
Evolutionary Quantitative Genetics of Genomic Imprinting
Authors: O’Brien Eleanor K , Wolf Jason B 
Published: November 2018

AbstractGenomic imprinting creates a difference in how maternal and paternal gene copies contribute to quantitative genetic variation and evolutionary change. To fully understand these impacts, O’Brien and Wolf develop a definitive extension to the classic....Genomic imprinting shapes the genotype–phenotype relationship by creating an asymmetry between the influences of paternally and maternally inherited gene copies. Consequently, imprinting can impact heritable and nonheritable variation, resemblance of relatives, and evolutionary dynamics. Although previous analyses have identified some of the quantitative genetic consequences of imprinting, we lack a framework that cleanly separates the influence of imprinting from other components of variation, particularly dominance. Here we apply a simple orthogonal genetic model to evaluate the roles of genetic (additive and dominance) and epigenetic (imprinting) effects. Imprinting increases the resemblance of relatives who share the expressed allele, and therefore increases variance among families of full or half-siblings. However, only part of this increased variance is heritable and contributes to selection responses. When selection is within, or among, families sharing only a single parent (half-siblings), which is common in selective breeding programs, imprinting can alter overall responses. Selection is more efficient when it acts among families sharing the expressed parent, or within families sharing the parent with lower expression. Imprinting also affects responses to sex-specific selection. When selection is on the sex whose gene copy has lower expression, the response is diminished or delayed the next generation, although the long-term response is unaffected. Our findings have significant implications for understanding patterns of variation, interpretation of short-term selection responses, and the efficacy of selective breeding programs, demonstrating the importance of considering the independent influence of genomic imprinting in quantitative genetics.