bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deletion of GIT1 Impacts eNOS Activity To Aggravate sFlt-1–Induced Preeclampsia Phenotype in Mice
Authors: Zhang Shenghong , Zou Cuili , Zhang Qiaoqin 
Published: October 2018

Abstract
Preeclampsia, a serious multisystem disorder specific to human pregnancy, remains a considerable burden of disease worldwide. Reduced nitric oxide bioavailability is proved to be crucial in the maternal and fetal pathophysiology of preeclampsia. G-protein-coupled Receptor Kinase Interactor-1 (GIT1) is a novel endothelial nitric oxide synthases (eNOS) interactor mediator. The aim of this paper is to investigate the effect of GIT1 on preeclampsia. Blood pressure (BP) was measured using a carotid catheter-calibrated eight-chamber tail-cuff system (CODA) at the same time daily. Urinary albumin excretion (UAE) was determined using Albuwell-M kits (Exocell Inc) and creatinine clearance (CCr) was determined by measuring urinary creatinine concentration with tandem liquid chromatography–mass spectrometry. The release of nitrite was analyzed to detect nitric oxide (NO) production using a Sievers Chemiluminescence NO Analyzer. NOS activity was examined by measuring the conversion of 3H-labeled l-arginine to 3H-labeled l-citrulline. BP was significantly increased in GIT1−/− mice with or without sFIT-1 treatment. In addition, GIT1−/− mice possessed higher UAE and lower CCr. Depletion of GIT1 impedes the NO production and placenta eNOS activity. Additional GIT1 attenuates sFlt-1-induced preeclampsia phenotypes. Our findings suggest that GIT1 significantly extenuates the sFlt-1-induced preeclampsia phenotypes by inhibiting eNOS activity, indicating a crucial role of GIT1 in the progression of preeclampsia.
Социокультурные детерминанты этнонациональной политики (на примере Новосибирска)
Authors: Персидская Ольга Алексеевна 
Published: October 2018

<p>В статье анализируется межэтническая ситуация и состояние межэтнических отношений в городе Новосибирске. Население города представляется как межэтническое сообщество — целостный социокультурный объект, элементы которого (этнические группы) одновременно интегрированы в сообщество, но сохраняют свою этнокультурную отличительность. Целью статьи является выделение комплекса социокультурных детерминант — значимых для сообщества факторов этносоциальной жизни, которые задают направление развития межэтнического сообщества. Отмечено, что, так как эти детерминанты оказывают значимое влияние на гармоничность межэтнических отношений в пространстве города, их выявление и анализ имеют особое значение для этнонациональной политики муниципального уровня.</p><p>Проанализированы результаты экспертного опроса, проведенного в Новосибирске в 2016–2017 гг. К социокультурным детерминантам отнесены, во-первых, сложности социально-экономического плана, которые формируют чувство незащищенности у принимающего сообщества и снижают уровень его толерантности к иноэтничным мигрантам. Во-вторых, анклавизационный процесс, который исключает места компактного расселения мигрантов из системы социально-культурного обмена. В-третьих, в качестве детерминанты, ставшей причиной ряда проблем в области межэтнических отношений, рассмотрена ограниченная эффективность мер, принимаемых административными структурами города для налаживания коммуникации между принимающим населением и диаспорами.</p><p>Проведенный анализ позволил заключить, что для гармонизации межэтнических отношений в городе следует повышать общий уровень благосостояния населения, наблюдать за изменениями в этнотерриторальной структуре города и искать принципиально новые механизмы коммуникации принимающего населения и мигрантов. Акцентировано, что для повышения своей эффективности муниципальная этнонациональная политика должна рассматривать в качестве объекта межэтническое сообщество в целом и учитывать широкий комплекс социокультурных детерминант, влияющих на его развитие.</p>
Социальное в социологии и в социальной философии сегодня
Authors: Федотова Валентина Гавриловна 
Published: October 2018

<p>Сегодня вопрос о парадигме социальных наук сталкивается с двумя трудностями. Одна из них состоит в избрании масштаба исследования (идет ли речь о дисциплине, теоретическом построении известного ученого определенной специальности, обсуждается ли способ решения некоторой задачи или речь идет о социальных науках в целом). Вторая проблема касается перспективы многопарадигмальности, господствующей сегодня в социальных науках.<strong></strong></p><p>В данной статье поставлен актуальный вопрос о проблематизации социального в социологии и социальной философии. Это назревший вопрос, поскольку и в социологии, и в социальной философии происходят значительные изменения и пересмотр многих прежних позиций. Автор обращается к дисциплинарной структуре социального знания, показывая новые взаимоотношения социологии и социальной философии. Выдвигается на передний план вопрос о том, чем социальная философия сегодня отличается от рассмотрения идей философии, обращенной к обществу прежде, и от своего марксистского предшественника — исторического материализма.</p><p>Существенной проблемой, рассмотренной в статье, являются причины изменения состояния социальной философии, расширившей горизонты своих исследований и повлиявшей тем самым на научный статус социологии. В данной статье осуществляется сравнение позиций Ж. Бодрийяра, Б. Латура, Э. Дюркгейма, Р. Мертона и других социологов, которое показывает их вклад в сближение с социальной философией и одновременно влияние последней на социологию. Процессуальный характер социальности и социального, примененный Б. Латуром, сегодня затронул исследовательские программы наук об обществе, делая культур-центристские подходы более значимыми, чем натуралистические, в исследованиях социологии и социальной философии.</p><p>В данной статье обсуждаются три этапа формирования современности (первый, второй и третий модерны) и их отражение в философском и социологическом знании, а также понимание социальной философии как ответа на вопрос об объективности социального и социальности в философских исследованиях.</p>
Profit And Loss Sharing System and Profitability of Islamic Rural Bank in East Jawa Indonesia
Authors: Saleh Mohammad , Sulistyo Agung Budi , Hisamuddin Nur , Roziq Ahmad 
Published: October 2018

This study aims to analyze, prove and find; (a) the effect of the profit sharing system on the risk of islamic rural banks; (b) the effect of the profit sharing system on efficiency of the islamic rural banks; (c) the effect of efficiency on risk of the islamic rural bank; (d) the effect of the profit sharing system on the profitability of the islamic rural banks; (e) the effect of risk on the profitability of islamic rural bank and (f) the effect of efficiency on the profitability of an islamic rural bank. This research is included in the type of explanatory research . This study uses path analysis with the SPSS program to test, analyze and prove the relationship of the influence of independent variables that affect the profitability of the islamic rural banks. This study found that (a) profit sharing system has no significant effect on the risk of the islamic rural banks; (b) the profit sharing system has a significant effect on the efficiency of the islamic rural banks; (c) efficiency has a significant effect on the risk of islamic rural banks; (d) the profit sharing system has no significant effect on profitability of the islamic rural banks; (e) the risk has a significant effect on the profitability of the islamic rural banks and (f) efficiency has a significant effect on the profitability of an islamic rural bank (IRB);.
Comites Villageois Et Problématique De La Gestion Des Points D’eau Dans L’arrondissement De Bayangam (Ouest-Cameroun)
Authors: Tchekote Hervé , Poka Angeline Noufin , Mbarga Fridolin Brice Nicolas Atekoa 
Published: October 2018

Households in Bayangam district in the west high land of Cameroon face many difficulties, one of the most important of which is access to water resources in terms of quality and quantity. Most people travel long distances in search of water, which is sometimes not reassuring. However, many boreholes as well as Village Committees of Water Point Management (CVGPE) have been set up in this locality. From this observation, the hypothesis according to which the existence of the Village Management Committees does not ensure the sustainable management of the water points in Bayangam was formulated. To verify this hypothesis, literature searches as well as direct observations in the study area were first conducted. Then, survey questionnaires from 150 households were administered. Finally, interviews with 14 resource persons representing the key players were conducted. The results of the study show that many CVGPEs have been established in the Bayangam district in recent decades, with the aim of ensuring better management of the water points set up by a multitude of stakeholders. However, most of these water points are almost non-functional or poorly maintained. Faced with this situation, it is important: to carry out a complete diagnosis of the works for a rehabilitation, to improve the choice of the members for more efficient services, to encourage a thorough involvement of the beneficiaries and a more remarkable support of the Bayangam commune to manage water points for a sustainable supply of populations.
Selectividad, timing y liderazgo de los multifondos-AFP en Chile
Authors: Sandoval Álamos Eduardo , Germany Morrison Benjamín 
Published: October 2018

Antecedentes: la evaluación de habilidades de selectividad, market timing y liderazgo en inversiones ejercido por los multifondos dependientes de las Administradoras de Fondos de Pensiones (AFP) es un tema de particular interés para los trabajadores en Chile, en especial luego de la implementación del primer proceso de licitación de cartera de nuevos afiliados.Metodología: haciendo uso del modelo de mercado cuadrático, con ventanas móviles de tiempo, junto con pruebas de causalidad de Granger, este artículo analiza el desempeño y liderazgo en políticas de inversión de seis AFP en los cinco multifondos existentes en Chile, durante el periodo que va desde septiembre de 2010 hasta marzo de 2016.Resultados: se indica que los multifondos muestran habilidades que no alcanzan a compensar las comisiones cobradas. Sin embargo, en términos de desempeño neto de comisiones, en comparación con el promedio de la industria destacan en todos los multifondos las AFP Modelo y Habitat, respectivamente. Además, no se detecta relación entre liderazgo en inversiones y desempeño. Conclusiones: el artículo finaliza destacando la importancia de las comisiones en el desempeño neto de los multifondos y en el potencial efecto que una mayor cantidad de competidores tendría en la industria. En este sentido, destaca la AFP Modelo, la cual muestra aproximadamente 1.63% de mejor desempeño que el promedio de la industria, debido a su más baja comisión detectada en el periodo completo de análisis.
THIRD PARTY’S ASSET CONFISCATION IN CORRUPTION CRIME
Authors: Supardi Supardi 
Published: October 2018

The article is intended to analyze and find the idea of legal philosophy foundation and develop the concept of proceeds confiscation of corruption crime are enjoyed by a third party, and find the ratio decidendi some of the verdicts related to asset confiscation to a third party without prior seizure, compared with asset confiscation that preceded seizure at the level of investigation.The article found three findings. First, the philosophy foundation of asset confiscation against third parties is in order to maximize the return of state losses due to corruption. Second, the ratio decidendi verdicts related to assets confiscation to a third party without prior seizure, such that verdicts were not contrary to th laws, human rights and justice. The interpretation of the provisions of Article 19 in conjunction with Article 18 of Law Number 31 Year 1999 on the Eradication of Corruption Criminal as amended by Law Number 20 Year 2001 provides an opportunity asset confiscation to a third party as long as the third party is not good manner. Third, to find advice for legal reform of the provisions regarding on confiscation to third party in corruption crime in order that is not touch with the third party’s rights as a subjek of asset confiscation.
Judgment of the Court of Justice in C-526/14 Tadej Kotnik and Others v. Državni zbor Republike Slovenije and permissibility of granting State aid to financial institutions
Authors: Stępkowski Łukasz 
Published: October 2018

The present work explores the Court of Justice’s decision in C-526/14 Tadej Kotnik and Others, along with its background, elements that led to it and subsequent developments in EU law. The author comments on the Court’s reasoning to discover whether the case was decided meritoriously or per incuriam.
Impact of Gastric Banding Versus Metformin on β-Cell Function in Adults With Impaired Glucose Tolerance or Mild Type 2 Diabetes
Authors: Xiang Anny H. , Trigo Enrique , Martinez Mayra , Katkhouda Namir , Beale Elizabeth , Wang Xinhui , Wu Jun , Chow Ting , Montgomery Cortney , Nayak Krishna S. , Hendee Fadi , Buchanan Thomas A. ,   RISE Consortium, Kahn Steven E. , Arslanian Silva A. , Edelstein Sharon L. , Ehrmann David A. , Nadeau Kristen J. , Palmer Jerry P. , Utzschneider Kristina M. , Temple Karla A. , Rue Abby , Barengolts Elena , Mokhlesi Babak , Van Cauter Eve , Sam Susan , Miller M. Annette , Atkinson Karen M. , Gebremedhin Tsige , Kernan-Schloss Abigail , Kozedub Alexandra , Morse Emily J. , Mather Kieren J. , Garrett Tammy , Hannon Tamara S. , Lteif Amale , Patel Aniket , Chisholm Robin , Moore Karen , Pirics Vivian , Pratt Linda , Gross Susan , Zeitler Philip S. , Williams Jayne , Green Melanie-Cree , Garcia Yesenia , Reyes Krista , Vissat Kathleen , Brown Nancy , Guerra Kristin , Porter Sonia , Caprio Mary , Savoye Bridget , Pierpont John M. , Lachin Ashley N. , Hogan Santica , Marcovina Jessica , Harting John , Albers Dave , Hill Peter J. , Savage  , Leschek Ellen W. 
Published: October 2018

OBJECTIVE
Type 2 diabetes (T2D) results from progressive loss of β-cell function. The BetaFat study compared gastric banding and metformin for their impact on β-cell function in adults with moderate obesity and impaired glucose tolerance (IGT) or recently diagnosed, mild T2D.

RESEARCH DESIGN AND METHODS
Eighty-eight people aged 21–65 years, BMI 30–40 kg/m2, with IGT or diabetes known for &lt;1 year, were randomized to gastric banding or metformin for 2 years. Hyperglycemic clamps (11.1 mmol/L) followed by arginine injection at maximally potentiating glycemia (&gt;25 mmol/L) were performed at baseline, 12 months, and 24 months to measure steady-state C-peptide (SSCP) and acute C-peptide response to arginine at maximum glycemic potentiation (ACPRmax) and insulin sensitivity (M/I).

RESULTS
At 24 months, the band group lost 10.7 kg; the metformin group lost 1.7 kg (P &lt; 0.01). Insulin sensitivity increased 45% in the band group and 25% in the metformin group (P = 0.30 between groups). SSCP adjusted for insulin sensitivity fell slightly but not significantly in each group (P = 0.34 between groups). ACPRmax adjusted for insulin sensitivity fell significantly in the metformin group (P = 0.002) but not in the band group (P = 0.25 between groups). HbA1c fell at 12 and 24 months in the band group (P &lt; 0.004) but only at 12 months (P &lt; 0.01) in the metformin group (P &gt; 0.14 between groups). Normoglycemia was present in 22% and 15% of band and metformin groups, respectively, at 24 months (P = 0.66 between groups).

CONCLUSIONS
Gastric banding and metformin had similar effects to preserve β-cell function and stabilize or improve glycemia over a 2-year period in moderately obese adults with IGT or recently diagnosed, mild T2D.
Study on the Productivity of Grass Forage as a Feed Source for Sambar Deer (Cervus unicolor) in Deer Captivity of PT. Gunung Madu Plantations
Authors: Setiawan Taufik , Harianto Sugeng Prayitno 
Published: October 2018

Sambar deer (Cervus unicolor) is one of the protected animals. However now the existence of sambar deer is increasingly threatened. Therefore, there is need for ex-situ conservation activities, one of the mis deer captivity in PT. Gunung Madu Plantations. An important component in the management of wildlife in captivity is the availability of food plants that need to be observed that aims to determine the productivity of forage as feed for sambar deer. The research method used a castle method by making the sample plots of grass. The results showed that there are two types of grass that feed the sambar deer in captivity. This type of feed consists pait grass (Axonopus compressus) and elephant grass (Pennnisetum purpureum). Pait grass (Axonopus compressus) has a productivity of 10,02 kg/m2/day, larger than the elephant grass (Pennnisetum purpureum) with a productivity of 3,94 kg/m2/day. Keywords: Cervus unicolor, grass, productivity of grass forage, PT. Gunung Madu Plantations.
UJI KINERJA ALAT PENGERING SILINDER VERTIKAL PADA PROSES PENGERINGAN JAGUNG (Zea mays ssp. mays)
Authors: Putra Made Aditya , Asmara Sandi , Sugianti Cicih , Novita Dwi Dian 
Published: October 2018

Jagung (Zea mays ssp. mays) merupakan salah satu tanaman pangan dunia yang terpenting selain gandum dan padi. Namun permasalahan yang dihadapi petani yaitu kadar air awal jagung yang tinggi dan cuaca yang tidak mendukung menjadi kendala yang dihadapi dalam proses pengeringan. Salah satu alternatif alat yang dapat digunakan untuk proses pengeringan jagung yaitu alat pengering tipe silinder vertikal. Tujuan dari penelitian adalah untuk mengetahui karakteristik pengeringan jagung dan megetahui efisiensi total alat pengering silinder vertikal selama proses pengeringan. Tahapan penelitian meliputi modifikasi alat dengan penambahan besi plat berbentuk segitiga pada bagian bawah ruang pengering untuk mengurangi titik kritis serta tahap pengujian yang dilakukan 3 kali berdasarkan kadar air 29% bb, 27,5% bb basis basah dan 26% bb. Hasil penelitian menunjukan waktu yang digunakan untuk mengeringkan jagung hingga mencapai kadar air 12-14 % pada setiap uji berbeda-beda. Uji kinerja 1 membutuhkan waktu 8 jam, uji kinerja 2 membutuhkan waktu 7 jam dan uji kinerja 3 membutuhkan waktu 6 jam. Tetapi laju pengeringan untuk setiap uji kinerja hampir memiliki nilai yang sama sekitar 5 kg H2O/Jam. Sehingga efisiensi total pengeringan pada uji kinerja 1 sebesar 23,56%, uji kinerja 2 sebesar 26,90% dan uji kinerja 3 sebesar 23,57%. Kata kunci : pengering silinder vertikal; jagung; suhu; kadar air
Multimodality imaging, single center, cross-sectional study in adolescents or young adults with repaired tetralogy of Fallout
Authors: Balducci Anna , Hasan Tammam , Donti Andrea , Egidy Assenza Gabriele , Lovato Luigi , Fabi Marianna , Gesuete Valentina , Prandstraller Daniela , Formigari Roberto , Ragni Luca , Angeli Emanuela , Gargiulo Gaetano D. , Picchio Fernando M. , Bonvicini Marco 
Published: October 2018

Background
Proper integration of multiple imaging modalities in the routine follow-up of patients with repaired tetralogy of Fallout (TOF) is poorly supported by data. We report our single center comparative study between cardiac magnetic resonance (CMR) and echocardiography to assess equipoise in the clinical utility of these two imaging methods in an unselected consecutive cohort of TOF patients referred to our outpatient clinic.

Material and methods
In this cross-sectional study, repaired TOF patients who underwent CMR and echocardiography within a 4-week period between 2010 and 2011 at our Center were included. Linear regression was used to analyze degree of inter modality correlation. A prediction model tested the association between functional data/probrain natriuretic peptide (Pro-BNP) with CMR.

Results
Fifty patients were included in the study (mean age 31 ± 18 years). The best predictors of right ventricle (RV) ejection fraction at CMR were tricuspid anular plane systolic excursion (tricuspid valve anular plane systolic excursion, R
2 0.37, P < 0.0001) and RV peak S-wave velocity (R
2 0.40, P < 0.001). Pro-BNP levels did present weak correlation with New York Heart Association functional class (R
2 0.31, P < 0.002) and QRS duration (R
2 0.32, P < 0.002) and a moderate correlation with right atrium area at CMR (R
2 0.46, P < 0.0001).

Conclusion
We found limited correlation between the two imaging modalities in the evaluation of RV after intracardiac repair of TOF. Pro-BNP level presents moderate correlation with right atrium area measured with echocardiography. Serial CMR evaluations are needed in this patient population, but they may be interchanged by routine echocardiography in particular in patients with normal or stable echocardiographic parameters.
Radial and femoral access for interventional fellows performing diagnostic coronary angiographies: the LEARN-Cardiogroup II, a prospective multicenter study
Authors: Omedè Pierluigi , Bertaina Maurizio , Cerrato Enrico , Rubio Lolo , Nuñez-Gil Ivan , Gili Sebastiano , Taha Salma , Macaya Carlos , Escaned Javier , D’Ascenzo Fabrizio 
Published: October 2018

Background
Safety and efficacy of radial and femoral access for coronary angiography performed by cardiology fellows remain to be evaluated.

Methods
In this multicenter prospective study, cardiology fellows selected the access site (among femoral, right and left radial artery) for coronary angiography. All bleeding events related to the access site and all complications (a composite of all bleedings and artery occlusion) were the co-primary safety end points. Success for each access site, procedural and radiological times and single components of primary outcome were the secondary ones.

Results
Overall, 201 patients were enrolled. Fellows chose right radial, left radial or femoral access in 164 (82%), 20 (10%) and 17 (8%) cases, respectively. All-cause bleedings were lower in radial cohort (4 vs. 19%; P = 0.001) mainly driven by minor bleedings (4 vs. 18%, P = 0.012). Also, overall complications were less frequent with the radial approach (18 vs. 30%, P = 0.03) and radial artery occlusion did not differ between right vs. left side (4 vs. 5%, P = 0.76). Procedural time (minutes) was similar between radial and femoral site (23 ± 9 vs. 22 ± 10, P = 0.91), as well as time of X-ray exposure (6 ± 3 vs. 4 ± 2, P = 0.11), DAP (Gy/cm2: 17 ± 11 vs. 18 ± 12, P = 0.74) and amount of contrast medium (ml: 106 ± 81 vs. 84 ± 43, P = 0.89). Success for access was significantly higher with radial artery (89 vs. 71%, P = 0.004).

Conclusion
Radial artery is the most exploited access by cardiologist fellows, leading to reduction in minor bleedings and higher success compared with femoral access. No differences in procedural time and radiation exposures were recorded.
Empirical Validation of Blue Ocean Strategy Sustainability in an International Environment
Authors: Dvorak Jiri , Razova Ilona 
Published: October 2018

Abstract
This article investigates the applicability of blue ocean strategy in regard to low-cost airlines in the civil airline industry. To do so, the commercial offers of selected airlines were compared to validate any attempts to apply the blue ocean strategy concept. This is followed by examining the time limitation of the concept in a competitive environment and is illustrated by the changes in the industry for the past 30 years and a comparison of offers from similar companies. The third issue is the evaluation of the further contribution of blue ocean strategy when it is recognized as time-limited. The importance of first-mover advantage, which could be based on the ability to capture an economy of scale and advantageously shape the market, is also discussed.