bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture?
Authors: Robinson Nicholas A , Johnsen Hanne , Moghadam Hooman , Andersen Øivind , Tveiten Helge 
Published: March 2019

Abstract
Stress during early life has potential to program and alter the response to stressful events and metabolism in later life. Repeated short exposure of Atlantic salmon to cold water and air during embryonic (E), post-hatch (PH) or both phases of development (EPH) has been shown to alter the methylome and transcriptome and to affect growth performance during later life compared to untreated controls (CO). The aim of this study was to investigate how the transcriptome of these fish responds to subsequent acute stress at the start feeding stage, and to describe methylation differences that might steer these changes. EPH treated fish showed the strongest down-regulation of corticotropin releasing factor 1, up-regulation of glucocorticoid receptor and 3-oxo-5-alpha-steroid 4-dehydrogenase 2 gene expression and a suppressed cortisol response 3 hr after the acute stress, differences that could influence hormesis and be affecting how EPH fish cope and recover from the stress event. Growth hormone 2 and insulin-like growth factor 1 were more strongly down-regulated following acute stress in EPH treated fish relative to E, PH and CO fish. This indicates switching away from growth toward coping with stress following stressful events in EPH fish. Genes implicated in immune function such as major histocompatibility class 1A, T-cell receptor and toll-like receptor also responded to acute stress differently in EPH treated fish, indicating that repeated stresses during early life may affect robustness. Differential DNA methylation was detected in regions mapping &lt;500 bases from genes differentially responding to acute stress suggesting the involvement of epigenetic mechanisms. Stress treatments applied during early development therefore have potential as a husbandry tool for boosting the productivity of aquaculture by affecting how fish respond to stresses at critical stages of production.
Usefulness of heart rate recovery parameters to monitor cardiovascular adaptation in elite athletes: The impact of the type of sport
Authors: Durmić T , Ðjelić M , Gavrilović T , Antić M , Jeremić R , Vujović A , Mihailović Z , Zdravković M 
Published: March 2019

Purpose
The purpose of this study is to determine heart rate (HR) recovery after maximal test in elite athletes who compete in high dynamic, high static, and in mixed sport disciplines; to assess differences in HR recovery between these groups of athletes; and to measure the association of HR index (HRI) with heart adaptation variables to determine whether these values were correlated with the type of exercise.

Methods
One hundred and ninety-four elite athletes were divided into three groups according to the predominant type of exercise performed: endurance (n = 40), strength-sprinter (n = 36), and ball-game players (n = 118). They performed maximal cardiopulmonary exercise testing on a treadmill and were subjected to echocardiography. The rate of decline (HR recovery) was calculated as the difference between maximum and recovery HRs (HRrec1 and HRrec3). The HRI was calculated as HRmax – 1-min post-exercise HR (HRrec1).

Results
The most significant correlation of HRI was with posterior wall diameter and left ventricular (LV) mass index (r = 0.43 and r = 0.51; p = 0.012 and p = 0.003, respectively). LV mass index [Beta (B) = 0.354, p = 0.001] was an independent predictor of HRI and HRrec1. HRI may be an effective tool for discrimination of physiological and “gray zone” LV hypertrophy, with area under the curve of 0.545 (95% CI = 0.421–0.669, p = 0.0432). HRI displayed a sensitivity of 50% and specificity of 52.2% at the optimal cut-off value of 23.5.

Conclusion
HR recovery pattern, especially HRI, may offer a timely and efficient tool to identify athletes with autonomous nervous system adaptive changes.
Uma análise das medidas de desempenho das empresas brasileiras listadas nos níveis diferenciados de governança corporativa da BM&F-Bovespa
Authors: Oliveira Nunes Rodrigues Angelo Antonio Davis , Krauter Elizabeth 
Published: March 2019

O objetivo da pesquisa é identificar quais as medidas contábeis podem ser agrupadas em fatores para melhor evidenciar o desempenho financeiro das empresas brasileiras com nível diferenciado de governança corporativa. Para o desenvolvimento desse trabalho é utilizada uma abordagem metodológica estruturada a partir de um problema de pesquisa quantitativo; com objetivo descritivo. Como procedimento técnico foi utilizado à análise multivariada fatorial dos principais indicadores contábeis. Essa análise foi realizada em uma amostra estatística das empresas listadas nos níveis diferenciados de governança corporativa na bolsa de valores do Brasil, com nível de confiança de 95% e com erro amostral de 5%, resultando em dezoito empresas. A aplicação da análise fatorial evidenciou que 5 fatores são capazes de explicar 83,43% das variáveis e explicam a forma como o desempenho, o giro do ativo e o fluxo de caixa impacto o endividamento das empresas.
Floating Microspheres: Recent Researchs
Authors: Asija Rajesh 
Published: March 2019

The purpose of writing this review on floating microspheres was to compile the recent literatureÃ‚Â with special focus on various gastro retentive approaches that have recently become leading methodologiesÃ‚Â in the field of orally controlled drug delivery to overcome physiological adversities such asÃ‚Â short gastric residence times and unpredictable gastric emptying times. Floating microspheres enhancesÃ‚Â drug bioavailability; reduce drug excretion and controlled drug delivery and better patient compliance.
A Case of Application of Bedside Continuous Renal Replacement Therapy on Treatment of MODS Caused by Fish Bile Poisoning
Authors: Zou Qi , Liu Cheng , Yu Gang , Deng Ximing , Yu Meiling 
Published: March 2019

One case of 54 years old female patient was admitted to hospital due to vomiting and diarrhea for 3 days and abnormal renal function for 1 day. The patient appeared repeatedly vomiting and watery stools 6 hours after eating 2 grain of raw carp fish bile and gradually appeared oliguresis, whole body skin yellow dye and fever symptoms. The condition of patient had no improvement after visiting the emergency department of local county hospital. She was checked in department of nephropathy in our hospital for further diagnosis and treatment. Because the patient's condition was serious and the function of liver and kidney was damaged, diagnosed as severe multiple organ dysfunction syndrome (MODS), she was transferred to ICU rescue to protect the liver, maintain water and electrolyte balance, control blood sugar, improve the circulation and give other drug treatments and actively carry out bedside continuous renal replacement therapy. Then the body temperature and hemogram of the patients became normal, liver and kidney function improved obviously, urinary production became normal, skin yellow dye faded and vital signs became stable. The successful treatment of this patient indicated that bedside continuous renal replacement therapy can not only have a good support for the kidneys but also reduce the waterfall effect of inflammatory of patients with severe MODS, which has great therapeutic effect on the multi organ dysfunction caused by fish bile poisoning.
Toxic Optic Neuropathy secondary to Systemic Chloramphenicol for Septic Arthritis: Case Report
Authors: Okonkwo Arthur 
Published: March 2019

Introduction – Chloramphenicol is a broad-spectrum antibiotic with excellent tissue penetration. Systemic use was popularised in the 1950s due to its affordability andease of preparation. It is now rarely used in developed countries due to its significant side effect profile including toxic optic neuropathy.
Case Description – A 68-year-old female presented to a neighbouring eye department with a 2-month history of bilateral visual deterioration, initially thought to be due to cataracts. However, due to the moderate cataract density and visual acuities of 6/60 and hand movements a medical history revealed that she had been taking systemic chloramphenicol for 6 months for chronic septic arthritis following a complicated total knee replacement. Following a normal ophthalmic examination besides reduced colour vision and constricted visual fields a diagnosis of toxic optic neuropathy secondary to chloramphenicol was made. Once systemic Chloramphenicol was stopped, her vision improved to 6/24 bilaterally although subjectively did not return to baseline.
Conclusion – Cataracts are a common cause of visual reduction, however, if the amount of cataract does not correlate with the extent of loss of visual acuity then an alternative cause must be considered. Early recognition of toxic neuropathy is key, as withdrawal of Chloramphenicol often results in improvement of visual symptoms.
Pola Interaksi Komunitas Mbojo Dengan Masyarakat Sasak (Studi Pada Komunitas Mbojo di Desa Peresak Kecamatan Narmada Kabupaten Lombok Barat)
Authors: Syarifudin Muhammad 
Published: March 2019

Abstrak
Tujuan penelitian ini adalah: 1.) Untuk mengetahui pola interaksi komunitas Mbojo dengan masyarakat Sasak di Desa Peresak Kecamatan Narmada Kabupaten Lombok Barat. 2.) Untuk mengetahui proses interaksi komunitas Mbojo dengan masyarakat Sasak di Desa Peresak Kecamatan Narmada Kabupaten Lombok Barat.
Penelitian ini, menggunakan jenis deskriptif dan fenomenologi. Yaitu tindakan manusia menjadi suatu hubungan sosial bila manusia memberi arti atau makna tertentu terhadap tindakannya itu, dan manusia lain memahami pula tindakannya itu sebagai sesuatu yang penuh arti. Sedangkan jenis deskriptif pada hakekatnya adalah mencari teori, bukan menguji teori. Metode ini menitik beratkan pada observasi dan suasana alamiah.
Hasil penelitian ini menunjukan bahwa: 1). Pola Interaksi komunitas Mbojo dengan masyarakat Sasak di Desa Peresak Kecamatan Narmada Kabupaten Lombok Barat adalah memegang prinsip hidup dari leluhurnya yaitu memberi contoh yang terbaik dengan bilhal dari yang lebih tua para tokoh komunitas Mbojo yang sekaligus menjadi panutan dan perilaku hidup komunitas Mbojo yang juga di dalamnya mengajarkan bahwa masyarakat harus lebih bersahaja dari pada pemimpinnya dalam berinteraksi. 2). Proses interaksi komunitas Mbojo dengan masyarakat Sasak di Desa Peresak Kecamatan Narmada Kabupaten Lombok Barat merupakan segala bentuk aktifitas atau kegiatan yang dilakukan setiap hari yang memegang teguh ajaran leluhur yang disebut ”maja la bo dahu” yang berarti malu dengan takut dan tercermin dalam tiga kategori, yaitu segi pekerjaan, segi kekeluargaan dan segi adat-istiadat yang merupakan keseluruhan pengetahuan dan pengalaman tentang segala aspek dan lika-liku yang berkaitan dengan kehidupan yang dipesankan secara lisan oleh nenek moyang kepada seluruh masyarakat adat Mbojo.
KONFLIK DAN RESOLUSI KONFLIK JAMA’AH MASJID KEMBAR MENARA TUNGGAL DI DESA BANYUMULEK KECAMATAN KEDIRI LOMBOK BARAT
Authors: Azwandi Azwandi 
Published: March 2019

Di desa Banyumulek terdapat dua masjid yang sekarang menjadi satu, masjid itu diberinama Masjid Kembar Menara Tunggal, sebelum masjid Kembar Menara Tunggal, sekitar enam puluh tahun yang lalu, berdiri salah satu masjid yang diberi nama Masjid Nurul Badiah, yang letaknya di Banyumulek Barat. Awalnya keberadaan masjid ini dimanfaatkan oleh warga Banyumulek sebagai tempat untuk beribadah dan sebagai pusat kegiatan keagamaan sebagaimana lazimnya. Namun Seiring berjalannya waktu, terjadi kesalahpahaman antar tokoh pemuka agama dan pengurus masjid itu. Sejak munculnya perbedaan pemahaman keagamaan ini, akhirnya konflik terbuka sesama jama’ah Masjid Nurul Badi’ah tidak dapat terelakkan, yang pada akhirnya jama’ah yang tidak sependapat mendirikan masjid baru yang lokasinya sangat berdekatan dengan Masjid Nurul Badi’ah, masjid baru tersebut diberi nama Masjid Silaturrahmi yang lokasinya berada di wilayah dusun Banyumulek Timur. Konflik dan ketegangan antar jama’ah terus berlangsung hingga puluhan tahun dan secara turun temurun, hingga pada akhirnya atas inisiatif dari tokoh pemuda pada saat itu, berusaha untuk menyatukan kembali jama’ah yang telah terpecah puluhan tersebut dengan melakukan negosiasi dan koordinasi dengan semua tokoh pemuka agama dan masyarakat, yang pada akhirnya menemukan titik temu untuk mengakhiri konflik yang berkepanjangan, dengan di adakan rapat besar antar dua pengurus masjid (Masjid Nurul Badi’ah dan Masjid Silaturrahmi) yang hasilnya di dalam rapat besar itu bahwa kepengrusan kedua masjid di bubarkan, dan kepengurusan masjid yang baru akan dibuat ulang, serta kedua masjid akan dirombak diganti dengan model masjid yang baru. Agar bangunan masjid bergabung menjadi satu maka dibuatkanlah jembatan penghubung yang sekarang dikenal dengan nama Menara Tunggal sebagai simbol pemersatu. Sejak dimulainya pembangunan Masjid Tunggal menara Tunggal dibangun pada tahun 2009 pertikain antar jamaah dapat diredam dan dapat dipersatukan kembali.
Financial system for a multinational family in Sharia and Law
Authors: Hadiri Yousf Faraj muhammad 
Published: March 2019

The issue of the financial system of a multinational family in shari'a and law is of great importance in the current era of the deterioration of rights in the case of family disputes, which often result in divorce. Hence, Islamic law has taken into account this subject with many rules and provisions that protect both spouses' rights and obligations. Some Arab countries have also taken this approach, but they have not been far from international laws that advocate women's freedom, as we find in Tunisian law, for example. Here we have examined this subject from a legitimate legal point to clarify the problem that some countries have occurred when they put the family laws.
The family laws have come up with sub-solutions that have made them fundamental issues that would raise the status of women and strengthen their legal and social status. This is the result of satisfying the demands of a predominantly political nature of religion, which made some laws rigid. The obligation of positive laws should not be affected by the purposes of Islamic law and its lofty principles of political, because codification does not prohibit Hara’am things, and it is not Hara’am for Halaal and non-ijtihad.
ISLAMIC VALUES ENCOUNTERED IN HUMAN LANGUAGE PRODUCTION AND COMPREHENSION AS A MENTAL PROCESS
Authors: Nurlaila Nurlaila 
Published: March 2019

This study concerned mainly on the islamic values encountered in human language production and comprehension as a mental process. The production of language of human being positioned in Broca’s area and comprehension of language is located in Wernike’s area which are located in human left brain. The process of language in human brain is very abstract; it could not be directly seen by naked eyes. It was done by activating some features of the brain such as Broca’s area, Wernike’s area, angular gyrus, motor cortex, etc. Based on psycholinguistics theory, ability to speak or produce meaningful sounds were innate in human. Its meant that human were genetically predisposed to learn and use language. The phenomenon were closely related to islamics values that those facts specifically and delibrately created by God; the Almighty Allah with certain purposes and that regularity was shown in the nature of thing in the earth. This research aims at investigating the islamic values encountered in human language production and comprehension. This is a descriptive qualitative reasearch that the researcher herself functioned as the key instrument. It was found out that there were several kinds of islamic values found in human language production and comprehension namely social, moral, economical, and religious values.

Key Words: Islamic Value, Language Production and Comprehension, Mental Process
THE EFFECTIVENESS OF USING PHOTOGRAPHS ON TEACHING WRITING NARRATIVE TEXT FOR NON-ENGLISH DEPARTMENT STUDENTS
Authors: Harintama Fitrana 
Published: March 2019

This study concerns about teaching writing, especially writing narrative text by using picture prompts as media. Picture prompts are believed can make the students relax to study and can encourage them to begin to write. Picture prompts have many advantages in teaching and learning writing. Related to the objective of the study, the aim of this study is to find whether picture prompts can help the students to get higher scores or not. This research will be done in UIN Maulana Malik Ibrahim Malang in Arabic Language and Literature Department with the research object of class A for experimental group and class B for control group. The objective of the study is to investigate the effectiveness of using picture prompts in writing class in helping students write narrative texts. The quasi-experimental research design will be used in writing this research. This research design was chosen because it was impossible for the researcher to randomize the subjects to the intended conditions. This was due to the fact that moving the students from one class to another in order to get the ideal groups for the sake of the experiment was not allowed. As the study deals with the students of two different classes, the explanation about teaching-learning processes will be applied to it. In the processes, the researcher will conduct pretest to know the students’ writing ability before getting treatment of writing narrative using picture prompts. After the treatment, the researcher conducts posttest to compare the result and to discover whether the students get higher score or not. Then the results of the research between two subjects will be analyzed using SPSS (Statistical Package for The Social Science) data analysis of group pair data.

Keywords: Picture Prompts, Narrative Text, Writing
Pajak dan Struktur Modal Perusahaan Manufaktur di Indonesia
Authors: Alfandia Nurlita Sukma 
Published: March 2019

Abstrak Perusahaan memiliki kecenderungan menggunakan hutang sebagai sumber pendanaan untuk meminimalkan pajak terhutang yang dibayarkan. Penelitian ini bertujuan untuk mengetahui pengaruh pajak dalam kebijakan hutang perusahaan. Variabel pajak diproksikan menjadi laba setelah pajak, tarif pajak efektif, dan tarif pajak marginal. Sedangkan, variabel kebijakan hutang diproksikan menjadi rasio hutang terhadap modal. Sampel penelitian yang digunakan merupakan perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia dan memiliki laporan keuangan yang telah diaudit untuk tahun 2012-2016. Selain itu, perusahaan tidak memiliki saldo modal negatif (defisiensi modal) dan mengalami kerugian fiskal, serta wajib menyajikan informasi yang diperlukan dalam penelitian. Sampel terpilih berjumlah sebanyak 135 perusahaan. Penelitian ini menggunakan analisis regresi sederhana dengan tiga model regresi yang dibuat. Berdasarkan pengujian yang dilakukan, diketahui bahwa variabel Earning After Tax (EAT) dan Effective Tax Rate (ETR) dapat mempengaruhi kebijakan hutang perusahaan. Sedangkan Marginal Tax Rate (MTR) tidak mempengaruhi kebijakan hutang perusahaan. Penelitian selanjutnya disarankan untuk menggunakan alternatif lain dalam pengukuran variabel ETR dan MTR. Selain itu, diharapkan penelitian berikutnya mempertimbangkan jenis usaha lain sebagai sampel penelitian. Kata kunci: Earning After Tax, Effective Tax Rate, Marginal Tax Rate, dan Debt to Equity Ratio.
Pengaruh Kinerja Non Keuangan dengan Tambahan Kinerja Lingkungan Terhadap Kinerja Keuangan pada Evaluasi Kinerja Berdasarkan Balanced Scorecard (BSC) dengan Komunikasi Manajemen Sebagai Variabel Pemoderasi
Authors: Handayani Dian Fitria , Supriyono R.A. 
Published: March 2019

Penelitian ini menguji pengaruh penggunaan perspektif lingkungan dalam BSC dan komunikasi manajemen sebagai variabel pemoderasi dalam evaluasi kinerja menggunakan BSC. Eksperimen laboraturium 2x2 between subjek dilakukan pada 113 mahasiswa Magister Manajemen dan Magister Akuntansi Fakultas Ekonomika dan Bisnis Universitas Gadjah Mada. Hasil penelitian menunjukkan bahwa penggunaan perspektif lingkungan dalam BSC belum mampu memberikan pengaruh dalam evaluasi kinerja berdasarkan BSC, Selain itu penggunaan komunikasi manajemen belum mampu meningkatkan pegaruh peggunaan perspektif lingkungan sebagai perspektif tambahan BSC dalam evaluasi kinerja, Namun Penggunaan Perspektif lingkungan dan tingkat komunikasi manajemen yang tinggi memberikan pengaruh yang signifikan terhadap keputusan pengalokasian bonus oleh tim evaluator yang dialokasikan kepada manajer.
Mitigasi Manipulasi Laba Aktivitas Rill dengan Keefektifan Internal Governance Studi pada Perusahaan Publik di Indonesia
Authors: Sembiring Carolyn Lukita , Nahumury Joicenda 
Published: March 2019

Penelitian ini bertujuan untuk menguji efektivitas internal governanace untuk memitigasi manipulasi laba aktivitas rill. Manipulasi laba aktivitas rill sebagai variabel dependen diukur dalam tiga proxy, yakni manipulasi aktivitas penjualan (Abnormal CFO), manipulasi biaya produksi (Abnormal Production), dan manipulasi biaya diskresioner (Abnormal Discreationer) berdasarkan Roychowdhury, 2006). Sedangkan variabel independen adalah internal governance, yang tergolong masih sedikit diteliti namun dibeberapa penelitian telah terbukti dapat menurunkan manajemen laba rill, penelitian ini mengukur internal governance berdasarkan Chen et al., (2016). Penelitian ini juga menguji variabel-variabel lainnya sebagai variabel pemoderasi, yakni kontrol dari dewan komisaris independen dan kepemilikan institusional yang diduga dapat memperkuat efektivitas internal governance dalam memitigasi manipulasi laba. Teknik analisis data yang digunakan adalah regresi linear berganda. Penelitian ini berhasil memberikan bukti bahwa internal governance mampu memitigasi tindakan manipulasi laba yang dilakukan manjer. Selain itu penelitian ini juga memberikan dukungan bahwa kepemilikan institusional dan dewan komisaris independen dapat memoderasi pengaruh antara internal governance dengan manajemen laba rill. Hasil penelitian ini dapat menambah referensi tentang mitigasi manajemen laba rill dan juga sebagai salah satu pertimbangan keputusan investasi jangka panjang di pasar modal bagi investor.
BUSINESS MODEL FINANCIALLY VIABLE FOR A RADIO FREQUENCY IDENTIFICATION (RFID) APPLICATION TO HALAL FOOD SYSTEM
Authors: Lathifah Artya , Narulidea Winda 
Published: March 2019

Recently, the halal concept has acquired a raising attention. This is as a result of the number of global Muslim population increasing annually. Halal concept has become more popular since Halal food consumers more aware and concern about the integrity of Halal status. Consumers also inquisitive about all the activities involved along the supply chain whether the products that they purchased were truly Halal. In order to accomplish the intent to further develop halal sector, something need to be done to introduce a comprehensive and suitable tracking and tracing technology for the sustainability of the halal product integrity. So, a proper technological framework that can support the entire supply chain of halal product process is needed. This paper discusses a financially viable business model for a Radio Frequency Identification (RFID) application to a halal food traceability system. We use a case study of RFID implementation in the chain of convenience stores from previous research. RFID will give benefits for integrity of the Halal Supply Chain by branding of the trustworthy of the “Halal” itself. For the economic aspect, RFID give advantage not only in responsess to the product availability and customer’s satisfaction but also real time information about demand. Keywords: Financially viable; Halal Supply Chain integrity, RFID, Traceability