bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Chiastic Structure of Seven Signs in the Gospel of John: Revisiting a Neglected Proposal
Authors: Crowe Brandon D. 
Published: September 2018

Abstract
Six signs in the Gospel of John are commonly recognized, but much less agreement has emerged on the total number and identity of the Johannine signs. In this article, I revisit the number and structure of signs in John, drawing on an often-neglected article from Marc Girard. Girard argued for seven signs in John, arranged in a chiastic pattern. Though modifications to Girard’s structure are needed, his argument has much to commend it and deserves a fresh hearing. Building on Girard’s structure, I argue that the “lifting up” or “glorification” of the Son is the seventh sign, and the pivot of the chiasm is found in the feeding of the multitudes in the wilderness, which underscores the centrality of abiding in the Son through faith.
Experimentenwet: carte blanche verdient nadere overweging
Authors: Ingelse P. 
Published: September 2018

Experimentenwet: carte blanche verdient nadere overweging
Tot 1 juni lag een wetsvoorstel Experimentenwet rechtspleging ter consultatie voor. Volgens dit voorstel krijgt de regering met het oog op innovatie van de rechtspraak voor onbepaalde tijd de bevoegdheid om bij AMvB te experimenteren met het Nederlands burgerlijk procesrecht. Concreet wordt onder meer gedacht aan experimenten met een eenvoudige procedure voor het MKB, met een deskundige lekenrechter naast de gewone rechter en met een harmonieuze alternatieve echtscheidingsprocedure. De experimenten moeten blijven binnen de grenzen van EU-recht, verdragen en de fundamentele beginselen van procesrecht, maar verder is de bevoegdheid vrijwel ongeclausuleerd.Het is de vraag of deze bevoegdheid strookt met (de strekking van) de Grondwet en past binnen de staatrechtelijke verhoudingen. De bevoegdheid is hoe dan ook te ruim doordat het experimenten mogelijk maakt en ook daadwerkelijk beoogt die de verwezenlijking van burgerlijke rechten en verplichtingen – tegen de wil van (een van) partijen – kan aantasten.De wetgever moet zich driemaal bedenken voordat hij een dergelijke twijfelachtige en grotendeels onnodige carte blanche in handen van de AMvB-regelgever speelt.Dat neemt niet weg dat de rechtspraak er zeker naar moet streven de civiele procedure eenvoudiger, sneller, flexibeler en effectiever te maken, waar nodig en aanvaardbaar met experimenten. Nog lang niet alle inventiviteit en creativiteit is uitgeput. Die experimenten hebben echter alleen zin, indien de financiële middelen worden verschaft om de consequenties te trekken uit een geslaagd experiment.
A Q-Probes Study Involving Utilization of Free Prostate-Specific Antigen, Factor V Leiden, and Hepatitis A Serology Tests
Authors: Schifman Ron B. , Perrotta Peter L. , Souers Rhona , Blond Barbara J. 
Published: September 2018

Context.—
Managing the utilization of laboratory tests is an important quality improvement activity that adds value to health care.

Objective.—
To examine utilization of 3 laboratory tests and identify factors that impact performance.

Design.—
Test utilization performance was evaluated by determining the frequency with which appropriate preconditions for testing were met. This included 30 testing episodes each involving (1) free prostate-specific antigen (PSA) when total PSA was within an appropriate interpretable range, (2) total anti–hepatitis A virus antibody when previous anti–hepatitis A virus antibody results were either negative or not done, and (3) factor V Leiden mutation when a previous result was not already available. Participants also provided information regarding some of their utilization policies and procedures for these 3 tests.

Results.—
The overall frequency with which testing criteria were met was 20.6% (163 of 790), 91.5% (649 of 709), and 95.2% (799 of 839) for free PSA, anti–hepatitis A virus antibody, and factor V Leiden, respectively. Utilization review was infrequent and done by 20.7% (6 of 29) of participants for factor V Leiden, 3.6% (1 of 28) for anti–hepatitis A virus antibody, and 3.6% (1 of 28) for free PSA. No practice or demographic characteristics were significantly associated with utilization performance for any test.

Conclusions.—
Utilization review was infrequent for the 3 tests examined. Variable amounts of unnecessary testing were observed for all tests, most frequently for free PSA, for which reporting results carried the added risk of diagnostic error from misinterpretation of results.
« Nous les femmes » de 1970 à 2017 à travers les traductions et adaptations de Our Bodies, Ourselves en français
Authors: Bessaïh Nesrine , Bogic Anna 
Published: September 2018

Le présent article se penche sur les traductions et adaptations françaises du classique féministeOur Bodies, Ourselves(OBOS) publié aux États-Unis en 1971. Nous explorons la diversité du « nous » dans l’expression « nous les femmes » à travers trois traductions et adaptations deOBOSréalisées dans des environnements francophones qui diffèrent par l’époque et la situation géopolitique. Nous postulons que ces projets de traduction témoignent des tentatives de représentations de la diversité du « nous » en recourant à la réflexivité et l’intersectionnalité, deux approches qui invitent les traductrices à réfléchir à leur propre posture vis-à-vis des autres femmes et à reconnaître les rapports de pouvoir inégaux qui peuvent exister entre elles. Dans la première partie de l’article, nous présentons les origines deOBOSavant de nous pencher sur les versions françaises réalisées respectivement en France et au Sénégal. Dans la deuxième partie, nous traitons de l’intersectionnalité, de son développement au sein du mouvement des femmes au Québec et de son rôle clé dans le processus d’adaptation adopté par la collective de militantes qui travaille actuellement au Québec à une nouvelle adaptation deOBOS. L’engagement des traductrices envers la réflexivité et l’intersectionnalité montre leur volonté de prendre en considération les rapports de pouvoir inégaux entre des femmes qui occupent différentes postures face au « nous les femmes ». De plus, le cas deOBOSillustre une approche de la traduction où la fidélité ne se mesure pas à l’aune de la retransmission exacte du texte; il s’agit plutôt d’une approche redevable au message et au projet politique d’une reprise de pouvoir des femmes sur leur vie.
La souveraineté peut-elle se transférer? Les enseignements de la traduction du traité de Waitangi (1840)
Authors: Lemieux René 
Published: September 2018

L’objectif de cet article est d’interroger le concept de souveraineté hérité de la modernité européenne à partir de sa « traduction » en maori dans le traité de Waitangi conclu en 1840 entre les chefs maoris d’Aotearoa (Nouvelle-Zélande) et l’Empire britannique. Le concept de souveraineté est difficilement traduisible en maori puisqu’il ne possède pas d’équivalent direct. Le termekawanatangachoisi par le missionnaire-traducteur Henry Williams n’est qu’une translittération du mot anglaisgovernorauquel le suffixe-tangaa été ajouté; ce terme rend mal l’idée du pouvoir absolu du souverain. Est-ce une « mauvaise » traduction pour autant? Henry Williams était-il incompétent? A-t-il plutôt voulu sciemment tromper les Maoris, comme le laissent entendre certains chercheurs? Le concept était-il lui-même intraduisible? Lorsqu’on analyse la traduction du termesouveraineté, on découvre qu’il n’y a pas d’équivalence formelle préétablie avant sa réalisation et que la souveraineté ne se transfère pas, mais se performe. Le contenu du concept est ainsi isomorphe à sa production : la souveraineté est une performance, et la traduction comme opération de création de termes participe à son actualisation. En utilisant un terme étranger mais profane pour rendre le concept, Henry Williams, sans peut-être le vouloir ou en être conscient, refuse la souveraineté dans son abstraction et, ce faisant, résiste aux tentatives de sceller l’interprétation du texte dans une unicité souveraine. Vue sous ce nouvel angle, la traduction de Williams participerait d’une « pensée sauvage » au sens de l’anthropologue Pierre Clastres, instituant une relativité toujours vulnérable, mais essentielle dans la perspective d’une traduction postcoloniale.
A comparison of perceptions of nuts between the general public, dietitians, general practitioners, and nurses
Authors: Brown Rachel Clare , Gray Andrew Robert , Yong Lee Ching , Chisholm Alex , Leong Sook Ling , Tey Siew Ling 
Published: September 2018

Background
Nut consumption at the population level remains low despite the well-documented benefits of their consumption, including their cardioprotective effects. Studies have suggested that advice from health professionals may be a means to increase nut consumption levels. Understanding how nuts are perceived by the public and health professionals, along with understanding the public’s perceptions of motivators of and deterrents to consuming nuts, may inform the development of initiatives to improve on these low levels of consumption. The aim of this cross-sectional study was to compare perceptions of nuts among three groups of health professionals (dietitians, general practioners, and practice nurses) and the general public in New Zealand (NZ), along with motivators of and deterrents to consuming nuts amongst the general public and their experiences of receiving advice around nut consumption.

Methods
The NZ electoral roll was used to identify dietitians, general practitioners (GPs), and practice nurses, based on their free-text occupation descriptions, who were then invited to complete a questionnaire with 318, 292, and 149 respondents respectively. 1,600 members of the general public were randomly selected from the roll with 710 respondents. Analyses were performed using chi-squared tests to look at differences in categorical variables and linear regression for differences in other variables between the four survey groups.

Results
Although there were significant differences between the four groups regarding the perceptions of nuts, in general there was agreement that nuts are healthy, high in protein and fat, are filling, and some nuts are high in selenium. We noted frequent agreement that the general public participants would consume more if nuts: improved health (67%), were more affordable (60%), or improved the nutrient content (59%) and balance of fats (58%) within their diets. Over half the respondents reported they would eat more nuts if they were advised to do so by a dietitian or doctor, despite less than 4% reporting they had received such advice. The most frequently selected deterrents to increasing nut consumption were: cost (67%), potential weight gain (66%), and leading to eating too much fat (63%).

Discussion
It is concerning that so few among the general public report receiving advice to consume more nuts from health professionals, especially given their apparent responsiveness to such advice. Health professionals could exploit the motivators of nut consumption, while also addressing the deterrents, to promote nut intake. These factors should also be addressed in public health messages to encourage regular nut consumption among the public. Educational initiatives could also be used to improve the nutritional knowledge of GPs and practice nurses with regard to nuts, although even dietitians were unsure of their knowledge in some cases.
DNA mismatch repair and CD133-marked cancer stem cells in colorectal carcinoma
Authors: Cheah Phaik-Leng , Li Jing , Looi Lai-Meng , Teoh Kean-Hooi , Ong Diana Bee-Lan , Arends Mark J. 
Published: September 2018

Background
Except for a few studies with contradictory observations, information is lacking on the possibility of association between DNA mismatch repair (MMR) status and the presence of cancer stem cells in colorectal carcinoma (CRC), two important aspects in colorectal carcinogenesis.

Methods
Eighty (40 right-sided and 40 left-sided) formalin-fixed, paraffin-embedded primary CRC were immunohistochemically studied for CD133, a putative CRC stem cell marker, and MMR proteins MLH1, MSH2, MSH6 and PMS2. CD133 expression was semi-quantitated for proportion of tumor immunopositivity on a scale of 0–5 and staining intensity on a scale of 0–3 with a final score (units) being the product of proportion and intensity of tumor staining. The tumor was considered immunopositive only when the tumor demonstrated moderate to strong intensity of CD133 staining (a decision made after analysis of CD133 expression in normal colon). Deficient MMR (dMMR) was interpreted as unequivocal loss of tumor nuclear staining for any MMR protein despite immunoreactivity in the internal positive controls.

Results
CD133 was expressed in 36 (90.0%) left-sided and 28 (70.0%) right-sided tumors (p < 0.05) and CD133 score was significantly higher in left- (mean ± SD = 9.6 ± 5.3 units) compared with right-sided tumors (mean ± SD = 6.8 ± 5.6 units) p < 0.05). dMMR was noted in 14 (35%) right-sided and no (0%) left-sided CRC. When stratified according to MMR status, dMMR cases showed a lower frequency of CD133 expression (42.9%) and CD133 score (mean ± SD = 2.5 ± 3.6 units) compared with pMMR tumors on the right (frequency = 84.6%; mean score ± SD = 9.2 ± 5.0 units) as well as pMMR tumors on the left (frequency = 90.0%; mean score ± SD = 9.6 ± 5.3 units) (p < 0.05). Interestingly, frequencies of CD133 immunoreactivity and CD133 scores did not differ between pMMR CRC on the right versus the left (p > 0.05).

Conclusion
Proficient MMR correlated with high levels of CD133-marked putative cancer stem cells in both right- and left-sided tumors, whereas significantly lower levels of CD133-marked putative cancer stem cells were associated with deficient MMR status in colorectal carcinomas found on the right.
Tibia functionality and Division II female and male collegiate athletes from multiple sports
Authors: Yingling Vanessa R. , Ferrari-Church Benjamin , Strickland Ariana 
Published: September 2018

Background
Bone strength is developed through a combination of the size and shape (architecture) of a bone as well as the bone’s material properties; and therefore, no one outcome variable can measure a positive or negative adaptation in bone. Skeletal robusticity (total area/ bone length) a measure of bones external size varies within the population and is independent of body size, but robusticity has been associated with bone strength. Athletes may have similar variability in robusticity values as the general population and thus have a wide range of bone strengths based on the robustness of their bones. Therefore, the purpose of this study was to determine if an athlete’s bone strength and cortical area relative to body size was dependent on robusticity. The second aim was to determine if anthropometry or muscle function measurements were associated with bone robusticity.

Methods
Bone variables contributing to bone strength were measured in collegiate athletes and a reference group using peripheral quantitative computed tomography (pQCT) at the 50% tibial site. Bone functionality was assessed by plotting bone strength and cortical area vs body size (body weight x tibial length) and robustness (total area/length) vs body size. Bone strength was measured using the polar strength-strain index (SSIp). Based on the residuals from the regression, an athlete’s individual functionality was determined, and two groups were formed “weaker for size” (WS) and “stronger for size” (SS). Grip strength, leg extensor strength and lower body power were also measured.

Results
Division II athletes exhibited a natural variation in (SSIp) relative to robusticity consistent with previous studies. Bone strength (SSIp) was dependent on the robusticity of the tibia. The bone traits that comprise bone strength (SSIp) were significantly different between the SS and WS groups, yet there were minimal differences in the anthropometric data and muscle function measures between groups. A lower percentage of athletes from ball sports were “weaker for size” (WS group) and a higher percentage of swimmers were in the WS group.

Discussion
A range of strength values based on robusticity occurs in athletes similar to general populations. Bones with lower robusticity (slender) were constructed with less bone tissue and had less strength. The athletes with slender bones were from all sports including track and field and ball sports but the majority were swimmers.

Conclusions
Athletes, even after optimal training for their sport, may have weaker bones based on robusticity. Slender bones may therefore be at a higher risk for fracture under extreme loading events but also yield benefits to some athletes (swimmers) due to their lower bone mass.
Virtual Roaming of Cultural Heritage Based on Image Processing
Authors: Chen Junzhe , She Xing , Fan Yuanxin , Shao Wenwen 
Published: November 2024

ABSTRACTWith the digital protection and development of cultural heritage as a focus, an analysis of the trends in cultural heritage digitization reveals the importance of digital technology in this field, as demonstrated by the application of virtual reality (VR) to the protection and development of the Lingjiatan site. The implementation of the Lingjiatan roaming system involves sequential steps, including image acquisition, image splicing, and roaming system production. A user test was conducted to evaluate the usability and user experience of the system. The results show that the system operates normally, with smooth interactive functions that allow users to tour the Lingjiatan site virtually. Users can learn about Lingjiatan's culture from this virtual environment. This study further explores the system's potential for site preservation and development, and its role in the integration of cultural heritage and tourism.
Phytochemicals and Their Nanoformulations for Targeting Hepatocellular Carcinoma: Exploring Potential and Targeting Strategies
Authors: Rab Safia Obaidur , Roopashree R. , Altalbawy Farag M. A. , Kumar M. Ravi , Chahar Mamata , Singh Manmeet , Kubaev Aziz , Alamir Hassan Thoulfikar A. , Mohammed Faraj , Kadhim Abed J. , Alhadrawi Merwa 
Published: November 2024

ABSTRACTHepatocellular carcinoma (HCC) continues to pose a global health concern, necessitating the exploration of innovative therapeutic approaches. In the recent decade, targeting tumor stroma consisting of extracellular matrix (ECM), immune cells, vascular system, hypoxia, and also suppressive mechanisms in HCC has attracted interest in repressing tumor growth and metastasis. Phytochemicals have attained considerable attention because of their manifold biological effects and high capacity for anticancer activities. These chemical agents have shown the capability to modulate different cells and secretions within the stroma of malignancies. In recent years, the development of nanoformulations has further enhanced the therapeutic potential of phytochemicals by improving their solubility, bioavailability, and targeted delivery to tumor tissues. This review aims to provide an encyclopedic overview of the potential of phytochemicals and their nanoformulations as promising therapeutic strategies for targeting HCC. The review initially highlights the broad array of phytochemicals exhibiting potent anticancer properties, including flavonoids, alkaloids, terpenoids, and phenolic compounds, among others. Then, the nanoformulations and modification of these agents will be reviewed. Finally, we will review the latest experiments that have examined the modulation of HCC using adjuvant phytochemicals and their nanoformulations.
Risk stratification in the clinical application of minimal residual disease assessment in acute myeloid leukemia
Authors: Zhang Congxiao , Gu Runxia , Wang Huijun , Zhou Chunlin , Li Yan , Liu Yuntao , Wei Shuning , Lin Dong , Liu Kaiqi , Fang Qiuyun , Gong Xiaoyuan , Gong Benfa , Qiu Shaowei , Zhang Guangji , Liu Bingcheng , Wang Ying , Mi Yingchang , Wei Hui , Wang Jianxiang 
Published: November 2024

AbstractBackgroundIn acute myeloid leukemia (AML), further investigation is warranted to integrate measurable residual disease (MRD) with genetic characteristics for formulating a dynamic prognostic system for predicting response and selecting appropriate postremission therapeutic strategies.MethodsThe authors incorporated MRD with genetic risk classification and assessed its impact on transplantation decision making within different risk cohorts, comprising 769 patients with newly diagnosed AML across three clinical trials. Only patients who achieved complete remission (CR) within two courses of chemotherapy were selected.ResultsIn the favorable‐risk and intermediate‐risk groups, patients who underwent transplantation according to the protocol experienced significant 3‐year overall survival (OS) benefits compared with those who did not (favorable‐risk group: hazard ratio [HR], 0.38; 95% confidence interval [CI], 0.20–0.73l p = .004; intermediate‐risk group: HR, 0.53; 95% CI, 0.33–0.85; p = .008). In the intermediate‐risk group, early detection of MRD positivity, even after the initial course of chemotherapy, was associated with a significantly elevated cumulative incidence of relapse (47.2% vs. 36.0%; p = .009) and a notable extension of OS with allogeneic hematopoietic stem cell transplantation (HR, 0.47; 95% CI, 0.28–0.79; p = .004). Conversely, patients who achieved MRD negativity at either of the two time points had comparable OS in the favorable‐risk and intermediate‐risk groups, regardless of whether they underwent transplant or not. In the adverse‐risk group, allogeneic hematopoietic stem cell transplantation led to improvements in OS irrespective of MRD status (HR, 0.51; 95% CI, 0.38–0.69; p < .001).ConclusionsEarly clearance of MRD demonstrated significant prognostic value, particularly for patients in the favorable‐risk and intermediate‐risk groups. Positive MRD status after two courses of intensive chemotherapy were associated with a higher relapse rate and inferior OS, necessitating allogeneic hematopoietic stem cell transplantation.
Traction Drive Motor for Small EVs Using Mass Producible Amorphous Laminated Cores
Authors: Kano Yoshiaki , Kanekiyo Hirokazu , Suzuki Yohei 
Published: November 2024

ABSTRACTThis study presents the development of a small electric vehicle (EV) traction drive motor using Fe‐based amorphous laminated cores that can be mass produced. The following innovative technologies are developed to realize the amorphous laminated core: (1) production technology for thicker amorphous alloy foils to reduce the number of machining operations and (2) punching press technology for amorphous alloy foils that improves the usability of the tool life and maintains quality. The interior permanent magnet synchronous motor (IPMSM) using the amorphous laminated core is designed to be compatible with a 4.5‐kW‐class small EV traction drive with high efficiency while satisfying the required torque characteristics. A prototype of the designed IPMSM was manufactured and evaluated. The test machine achieves a maximum efficiency of 98.7% and a wide range of efficiencies exceeding 97%. Additionally, the prototype motor exhibit improved efficiency in all operating points compared with a prototype manufactured using an electrical steel sheet.