bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin Improves Erythropoietin Hyporesponsiveness via Suppression of Inflammation
Authors: Hameed Evan Noori , Hadi AL Tukmagi Haydar F. , Allami Hayder Ch Assad 
Published: August 2019

Background:
Inadequate response to Erythropoietin Stimulating Agents (ESA) despite using
relatively larger doses regimen represents a potential risk factor of Cardiovascular (CV) related
mortality in addition to health-care economic problems in anemic patients with Chronic Kidney Disease
(CKD). Erythropoietin (EPO) hyporesponsiveness related to inflammation has been increased
progressively. Melatonin is well known as a potent anti-inflammatory agent. Therefore, the current
study was designed to evaluate whether melatonin could improve anemic patients response to EPO.

Methods:
This single controlled clinical study was carried out in 41 CKD patients with hemoglobin
(Hb) levels less than 11g/dl divided randomly in a 1:1 ratio into 2 groups; treatment group who received
5mg melatonin plus their regular treatments and control group who received their regular
treatments only. Hematological and iron status parameters include Hb level, serum iron (S. iron),
Transferrin Saturation Ratio (TSAT) and serum ferritin (S. ferritin) in addition to inflammatory parameters
that include tissue necrotic factor alfa (TNF-α), interleukin-1beta (IL-1β) and interleukin-6
(IL-6) determined before and after 12 weeks of treatment.

Results:
Melatonin remarkably increases the Hb level with a significant increase in S. iron and TSAT
compared to baseline. The elevation of S. iron and TSAT was significantly higher in the melatonin
group. Additionally, all inflammatory markers estimated were reduced significantly by melatonin
compared to base line and control group.

Conclusion:
The results of the current study showed that melatonin has an advantageous effect on
improving EPO response in anemic patients with CKD.
Production and Characterization of L-Asparaginases of Streptomyces Isolated from the Arauca Riverbank (Colombia)
Authors: Arévalo-Tristancho Estefanía , Díaz Luis E. , Cortázar Jorge E. , Valero Manuel F. 
Published: August 2019

Introduction:L-asparaginase, is known as an anti-cancer agent, mainly used in acute lymphoblastic leukemia, which prevents the proliferation of tumor cells. This study shows that there are unexplored regions in Colombia that can be sources of obtaining this enzyme and that the optimization of the production of L-asparaginase from native isolates can be determined in the search for alternatives to commercial drugs.Materials and Methods:Selection and identification ofStreptomycesamongActinobacteriaisolated from the Arauca riverbank for L-asparaginase producers are described. In addition, the effect of carbon and nitrogen sources, pH, temperature and agitation rate are studied for L-asparaginase activity in liquid culture using Plackett-Burman design and Taguchi methodology. Kinetic characterization of a purified L-asparaginase and its cytotoxic potential are evaluated too.Results:Seven of seventy-eight actinobacterial strains were selected as L-asparaginase producingStreptomycesshowing a high L-asparaginase/L-glutaminase ratio in liquid culture with lactose as substrate. The strain 112 identified asStreptomyces lacticiproducenswas chosen for L-asparaginase production at these culture conditions: lactose 0.25%, L-asparagine 0,015%, malt extract 0,015%, pH 7.36, 32°C and 130 rpm. Enzymatic studies of the purified L-asparaginase showed that the optimal pH and temperature were 6 and 37.5°C, respectively. This purified enzyme had an IC50of 36.74 µg/mL on THP-1 cells.Conclusion:S. lacticiproducensisolated from the Arauca riverbank is a new source for the production of a high activity L-asparaginase, creating expectation of its availability as a drug for the acute lymphoblastic leukemia treatment.
An Ethnomedicinal Survey of Indigenous Knowledge on Medicinal Plants in the Traditional Authority Chikowi in Zomba, Malawi
Authors: Chikowe Ibrahim , Mnyenyembe Moira , Jere Stuart , Mtewa Andrew G. , Mponda John , Lampiao Fanuel 
Published: August 2019

Introduction:
Medicinal plants and ethnomedicinal studies continue playing a
significant role in herbal products development and traditional knowledge conservation.
Calls for ethnomedicinal studies have increased recently to unleash the potential in medicinal
plants and document verbal traditional knowledge. This study recorded the medicinal plants
administered by traditional practitioners in the Traditional Authority Chikowi area of Zomba
district in Malawi.

Methodology:
This cross-sectional study was conducted for 2 weeks in September 2017.
Semi-structured questionnaires were administered to traditional medicine practitioners using
snowball sampling in the company of botany personnel from the National Herbarium and
Botanical Gardens (NHBG). Data collected included plant local names, medicinal uses, parts
used, preparation methods and administration methods to clients. Some species were photographed
and identified in the field by the NHBG officers.

Results:
Five traditional practitioners were interviewed. Fifty-nine medicinal plant species
belonging to 38 families were used as prophylaxis and treatment for 27 communicable and
non-communicable diseases/conditions. Fabaceae family (papilionoideae 11.9%, mimosoideae
5.1%, caesalpinioideae 1.7%) had the largest percentage of species (18.6%). Preparation
methods ranged from infusion (38.0%) to cream (2.0%). Of these, 86.0%, 12.0% and
2.0% were administered orally, topically and rectally respectively. Roots were the most used
part (60.8%) while the least used was flowers (1.3%). Nearly two-thirds were trees or shrubs
(32.2% each).

Conclusion:
The area has a rich biodiversity of medicinal plant species and knowledge scientists
can use as a baseline for identification of plant species, bioactive compounds and
preparations with useful medicinal properties.
The Formation of Manganous Dithionate in the Manganese Oxide Flue Gas Desulfurization
Authors: Pu Pengyan , Yang Lin , Yao Lu , Jiang Xia , Jiang Wenju 
Published: August 2019

Background & Objective:
The Manganous Dithionate (MnS2O6, MD) was formed during the flue gas desulfurization process over manganese ore slurry, which impeded the
following valuable using of the desulfurized lixivium. In this study, the MD formation and
restraint in the desulfurization process using manganese was carefully investigated.

Methods & Results:
Different type of manganese oxides/carbonate was used for the flue gas
desulfurization, and the MD formation with the process was detected to obtain the basic information
of the MD formation and restraint. The MD was directly formed by the uncompleted
oxidation of SO2 with MnO2. The increased MD formation by Mn2O3, Mn3O4 and
MnCO3 was due to their influence on the pH of slurry. Processability study showed that an
increase in the acidity of slurry, the gaseous oxygen content and reaction temperature could
inhibit the MD formation effectively. The optimum operating conditions to restrain the MD
formation were temperature higher than 60°C, 10% or more oxygen and slurry pH lower
than 3. The formed MD content was different with the different manganese compounds,
which cloud be controlled by the ore-proportioning in industrial application.

Conclusion:
Using anolyte to prepare the manganese slurry for desulfurization could perform
a good MD formation restraint, which provided valuable technical support for the
cleaner production of electrolytic manganese industry.
Postinjury Complications: Retrospective Study of Causative Factors
Authors: Warnack Elizabeth , Pachter Hersch Leon , Choi Beatrix , DiMaggio Charles , Frangos Spiros , Klein Michael , Bukur Marko 
Published: August 2019

BackgroundInjury care involves the complex interaction of patient, physician, and environment that impacts patient complications, level of harm, and failure to rescue (FTR). FTR represents the likelihood of a hospital to be unable to rescue patients from death after in-hospital complications.ObjectiveThis study aimed to hypothesize that error type and number of errors contribute to increased level of harm and FTR.MethodsPatient information was abstracted from weekly trauma performance improvement (PI) records (from January 1, 2016, to July 19, 2017), where trauma surgeons determined the level of harm and identified the factors associated with complications. Level of harm was determined by definitions set forth by the Agency for Healthcare Research and Quality. Logistic regression was used to determine the impact of individual factors on FTR and level of harm, controlling for age, gender, Charlson score, injury severity score (ISS), error (in diagnosis, technique, or judgment), delay (in diagnosis or intervention), and need for surgery.ResultsA total of 2216 trauma patients presented during the study period. Of 2216 patients, 224 (224/2216, 10.10 %) had complications reported at PI meetings; of these, 31 patients (31/224, 13.8 %) had FTR. PI patients were more likely to be older (mean age 51.3 years, SE 1.58, vs 46.5 years, SE 0.51; P=.008) and have higher ISS (median 22 vs 8; P<.001), compared with patients without complications. Physician-attributable errors (odds ratio [OR] 2.82; P=.001), most commonly errors in technique, and nature of injury (OR 1.91; P=.01) were associated with higher levels of harm, whereas delays in diagnosis or intervention were not. Each additional factor involved increased level of harm (OR 2.09; P<.001) and nearly doubled likelihood of FTR (OR 1.95; P=.01).ConclusionsPhysician-attributable errors in diagnosis, technique, or judgment are more strongly correlated with harm than delays in diagnosis and intervention. Increasing number of errors identified in patient care correlates with an increasing level of harm and FTR.
A UTOPIA NA OBRA DE H.P. LOVECRAFT: UMA LEITURA POLÍTICA DE AT THE MOUNTAINS OF MADNESS
Authors: Dutra Daniel 
Published: August 2019

O presente artigo visa analisar a novela de horror At the Mountains of Madness (1936), de H.P. Lovecraft, sob uma perspectiva sociopolítica. Para tanto realizamos uma leitura comparativa com os ensaios políticos do autor sobre a Grande Depressão dos anos 30 – mais especificamente os textos “Some Repetitions on the Times” (1933), “A Layman Looks at the Government” (1933) e “The Journal and the New Deal” (1934). Argumentamos que ha indícios claros de que as transformações socioeconômicas provocadas pela Grande Depressão influenciaram o processo criativo de H.P. Lovecraft, levando-o a abordar temas até então nunca discutidos tanto em seus ensaios quanto em sua obra ficcional.
Acquired Generalized Lipodystrophy: A New Cause of Anti-PD-1 Immune-Related Diabetes
Authors: Jehl Alexandre , Cugnet-Anceau Christine , Vigouroux Corinne , Legeay Anne L. , Dalle Stéphane , Harou Olivier , Marchand Lucien , Lascols Olivier , Caussy Cyrielle , Thivolet Charles , Laville Martine , Disse Emmanuel 
Published: August 2019

OBJECTIVE
Anti–programmed cell death-1 (anti-PD-1) antibodies have revolutionized advanced cancer therapy. Anti-PD-1 therapy is responsible for immune-related adverse events, with frequent endocrine manifestations, including acute-onset type 1 diabetes. Acquired generalized lipodystrophy (AGL) is a rare disease, believed to be immune mediated, characterized by loss of adipose tissue and insulin resistance–associated complications.

RESEARCH DESIGN AND METHODS
We describe the first reported case of AGL induced by immune checkpoint therapy.

RESULTS
A 62-year-old woman with metastatic melanoma treated with nivolumab was referred for major hyperglycemia, hypertriglyceridemia, and nonalcoholic steatohepatitis. She had presented with a rapidly progressive generalized loss of subcutaneous adipose tissue. Diabetes was associated with severe insulin resistance and undetectable plasma leptin. Subcutaneous biopsy revealed atrophic adipose tissue infiltrated with cytotoxic CD8+ T lymphocytes and fibrosis.

CONCLUSIONS
AGL is an additional immune-related adverse event of anti-PD-1 therapy that leads to severe insulin resistance–associated complications.
Autobiography as a Quest for Identity
Authors: Subramony Dr R. 
Published: August 2019

What is the difference between biography and autobiography? The former is more revealing and hence is more in demand. According to Graham Greens autobiography is only ‘a sort of life’. It is more selective. He observed that ‘it begins later and ends prematurely. If one cannot close a book of memoirs on the death bed, any conclusion must be arbitrary’. The reader of an autobiography becomes an interested witness to the writer’s account of his life. He is a keen observer of an author’s obsession with his identity and the crises of his life. The reader can find lessons for his own life from the author’s account. Necessarily, he is more an active participant of the creative process while reading an autobiography than while reading a novel. The reader is bound to find parallels between the experiences of the writer and his own. The history of autobiographical writing dates back to the ‘confessions’ of St. Augustine written in the second half of the fourth century. The difference between Christian idea of confession and autobiography as it developed in the eighteenth, nineteenth and our century must be noted. Peter Abbes says that ‘confessions, in their traditional form, crave forgiveness, autobiography desires understanding. Confessions are devoted to salvation, autobiographies to individuation’. It is only with Rousseau that the form of memoirs took its present shape – ‘simply myself’. The importance of the individual reader was understood by autobiographers after Rousseau. Gibbon, Goethe, Ruskin, Wordsworth, John Stuart Mill, Newman, Darwin and a host of others gave the field of autobiography its pride of place. In our century autobiography has been used as a means for relentless self-exploration and for organising our experience.
La participación de México en la Convención Marco de las Naciones Unidas sobre el Cambio Climático
Authors: Torres Ramírez Blanca 
Published: August 2019

El presente artículo examina la participación del gobierno de México en el sexenio 2012-2018 en las negociaciones sobre cooperación y coordinación internacional para enfrentar el cambio climático dentro del ámbito de la Convención Marco de las Naciones Unidas para el Cambio Climático (CMNUCC). Se hace referencia también a la participación de actores subestatales y no estatales, como empresas y organizaciones no gubernamentales en ese ámbito. A la par que se refiere las posturas y coaliciones que se dan en distintos temas entre países de distintas regiones, acordes con sus niveles de desarrollo e intereses y capacidades, se destaca el papel activo de la cancillería en contextos de negociación de temas complejos, así como de situaciones desafiantes, tales como la llegada de Donald Trump a la presidencia de Estados Unidos y su decisión de retirar a su país del Acuerdo de París. Esta participación activa en las negociaciones internacionales permitió darle importancia a un tema que no se consideraba prioritario en la agenda de desarrollo del sexenio.
Metabolic Syndrome and Myocardial Involvement in HIV-Infected Patients
Authors: Bajdechi Mircea , Micu Cristina-Elena , Rugină Sorin , Stoian Georgiana-Elena , Gurghean Adriana 
Published: August 2019

Abstract
The current HAART has modified natural history of HIV infection and it has practically turned the disease into a manageable chronic condition. Even though the benefits of HAART use are overwhelmingly greater than possible metabolic syndrome and cardiovascular disease risks, close management of those patients is called for, especially due to the fact that general population risk factors now overlap with specific ones in this population.
Cardiovascular screening for HIV-infected patients who are receiving HAART must be done constantly with a collaboration between the infectious disease specialist and the internist.
SUNSCREEN LOTION OF MIANA LEAVES (COLEUS ATROPURPUREUS BENTH)
Authors: Rusli Rolan , Rosniah Rosniah , Fridayanti Aditya 
Published: August 2019

Sunscreen can protect the skin from the UV radiation. One of the plants that have the potential to be utilized as active ingredients of sunscreen lotion is miana leaves (Coleus atropurpureus Benth). Lotion made in 3 formulas F1, F2 and F3. Lotion tested its stability with a freeze-thaw method, and evaluated organoleptic, homogeneity, pH, viscosity and scatterness and tested sunscreen activity of lotion preparation. The preparation shows good homogeneity, and has oleum rosae odor and a thick consistency with the lotion color is brown (F1), dark brown (F2) and slightly greenish brown (F3). Spreading, viscosity, and pH of the lotion meet the Indonesia Standart requirement. The lotion formula comes in the category of fast tanning (F2) and extra protection (F3) sunscreen.
GUILLAIN-BARRE SYNDROME: A CASE REPORT
Authors: Pati Nikunja Basini , Begum Ruksana , Vani. P Salome Satya , R Soujanya 
Published: August 2019

Guillain-Barre syndrome (GBS) is a complicated degenerative neurological disorder which can be acute or chronic in nature. It is an acquired condition which is characterized by progressive, symmetrical, proximal and distal tingling and weakness. Muscle stretch reflexes are decreased to absent and loss of sensation is common. Etiology remains unclear but pathophysiology includes demyelination of spinal nerve roots. Death is rare. Early diagnosis and prompt referral should occur in severe cases due to the incidence of potential ventilation failure and cardiovascular instability in some patients. The case of a 26-year-old male presenting to a physician is described. The importance of a correct diagnosis by the physician and the subsequent management is reviewed.
Key words: Guillain-Barre syndrome, extremity weakness, peripheral nerves, trauma
As controvérsias legais quanto à revogação da majorante do crime de roubo com emprego de arma: a (in)constitucionalidade do art. 4º da lei 13.654/2018
Authors: Da Costa Mislene Lima , Valverde Marcos Cesar Silva , Santos Carolina Rosa , Cardoso Franciele Silva 
Published: August 2019

O presente artigo objetiva analisar as controvérsias trazidas com o advento da lei 13.654/2018 no que concerne ao crime de roubo com emprego de arma. O art. 4º da referida lei revogou o inc. I, do § 2º, do art. 157 do Código Penal, que previa o aumento de pena de 1/3 até a metade em caso de a violência ou ameaça perpetrada pelo agente ser exercida com o emprego de arma. Com essa modificação legal, essa modalidade de crime passou de roubo circunstanciado para roubo simples. A alteração legislativa promovida pelo art. 4º tem proporcionado intensos debates no meio jurídico e nas instâncias judiciais, sobretudo pelos questionamentos quanto à constitucionalidade do referido dispositivo que foi incluído pela coordenação de redação legislativa do Senado Federal, na fase final de revisão do texto legal. A (in)constitucionalidade do art. 4º da lei 13.654/2018 não foi declarada pelos tribunais superiores, contudo, infere-se dos projetos de lei PLS n. 279/2018 do Senado Federal, e PLS n. 10541/2018 da Câmara dos Deputados, que a intenção dos legisladores é retornar o crime de roubo praticado com emprego de arma como um crime majorado.
Cotidiano e materialidade da escola primária oitocentista: ruídos entre público e privado
Authors: Barra Valdeniza Maria Lopes da 
Published: August 2019

Eis aqui a reunião de um conjunto de fatos “miúdos” cujas marcas são pinçadas no curso do século XIX, com vistas a pensar a implementação da escola primária. Embora a ênfase seja sobre a escola de Goiás, de vez em quando, como forma de alicerçar o entendimento, chamar-se-á evidências da escola primária da de São Paulo ou outras pistas, de escala nacional, num movimento que, nos seus limites, cuida da relação entre singularidade e totalidade. Face a este conjunto, o esforço de identificar o que está nas ordens da repetição e do acontecimento. Este último, o acontecimento, segundo Braudel (1995) se acredita “único” e se associa à instantaneidade. Enquanto certos atos ou fatos se repetem e, em acontecendo, tornam-se generalidade ou estrutura. Inscritos no “rés do chão”, na “zona opaca” - o cotidiano - a repetição de fatos miúdos guarda em si, a “força da inércia” e se revela na capacidade de invadir diferentes níveis da sociedade, portanto, uma “obreira da história” que não se pode menosprezar. Em síntese, é esta a senha de acesso ao movimento de instituição da especificidade do espaço físico da escola primária no curso do século XIX.
Urgensi Bimbingan Pra Nikah Terhadap Tingkat Pencerian
Authors: Ridho Muhammad 
Published: August 2019

Penelitian ini bertujuan untuk mengetahui Urgensi Bimbingan pra nikah di KUA Kecamatan Muara Tabir. Untuk mengetahui faktor pendukung dan penghambat Bimbingan pra nikah terhadap tingkat perceraian di KUA Kecamatan Muara Tabir. Ingin mengetahiu upaya apa yang dilakukan KUA terhadap bimbingan pra nikah dalam mengurangi tingkat perceraian di Kecamatan Muara Tabir. Hasil penelitian ini menunjukkan Tingginya angka perceraian diantaranya disebabkan, banyak pasangan suami istri (Pasutri) yang tidak mengikuti bimbingan pra nikah. Faktor-faktornya adalah, Terjalinnya kerja sama dengan instansi-instansi yang terkait dengan baik, sehingga akan memperlancar dan membantu, adanya lembaga pendidikan nonformal, peran serta dari tokoh-tokoh agama, Akhirnya peneliti merekomendasikan kepada Ketua Kantor Urusan Agama Kecamatan Muara Tabir dan pasutri agar memperhatikan pasutri mengikuti bimbingan pra nikah selama 10 hari tersebut, para calon pengantin akan diberi materi menyangkut segala aspek kehidupan yang berkaitan tentang pernikahan. Disiplin dalam waktu mengikuti bimbingan.
PROFITABILITAS TERHADAP RETURN SAHAM
Authors: Devy Happy Sista 
Published: August 2019

The development of the capital market is currently followed by the development of the stock
market is increasingly in demand by investors as well, seen from data on Indonesia Stock
Exchange (IDX) which shows that the stocks included in the sharia has increased. An investor
will do the analysis to make an investment decision. The analysis is technical and fundamental.
One of the fundamental analysis is profitability ratio analysis issued by the company. Good
financial performance will be the information used as a positive signal by investors, because
companies that have good financial performance will provide more benefits for investors. The
purpose of this research is to examine and analyze profitability variables on stock returns in
Jakarta Islamic Index (JII) period 2012-2016. Population of this research is a company included
in the Jakarta Islamic Index (JII). This research using sample criteria, we obtained a sample of 21
companies included in the Jakarta Islamic Index (JII) for the period of 2012-2016 and published
annual financial report data on Indonesia Stock Exchange (IDX) required during the study. The
variables used in this research are earning per share (EPS), return on equity (ROE), return on
asset (ROA), return on sales (ROS), return on investment (ROI), size as control variable, and
stock return as the dependent variable. Result of this research show that investor on Jakarta
Islamic Index (JII) see simultaneously the profitability ratio as a signal for investment decision
making. Variable size can be used as control variable in that used in this research. Profitability
ratios that are taken by investors are return on assets (ROA), earnings per share (EPS), and
return on investment (ROI). So that should be a special attention for companies incorporated in
the Jakarta Islamic Index (JII) to increase investor interest to invest in the company.

Keywords : stock return, profitability ratio, size.