bluuebunny/crossref_metadata_2025_split huggingface dataset:
INFLUÊNCIA DA FORMA DE OBTENÇÃO DO SALDO DE RADIAÇÃO NA COMPARAÇÃO DE MÉTODOS DE ESTIMATIVA DA EVAPOTRANSPIRAÇÃO DE REFERÊNCIA
Authors: Turco José Eduardo Pitelli , Faria Manoel Teixeira de , Fernandes Edemo João 
Published: October 2018

INFLUÊNCIA DA FORMA DE OBTENÇÃO DO SALDO DE RADIAÇÃO NA COMPARAÇÃO DE MÉTODOS DE ESTIMATIVA DA EVAPOTRANSPIRAÇÃO DE REFERÊNCIA José Eduardo Pitelli Turco; Manoel Teixeira de Faria; Edemo João FernandesDepartamento de Engenharia Rural, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Câmpus de Jaboticabal, Jaboticabal , SP, jepturco@fcav.unesp.br 1 RESUMO Uma maneira freqüentemente utilizada para verificar a eficiência de métodos de estimativa da evapotranspiração de referência (ETo) em diferentes situações e locais é por meio de comparação com um método padrão. Porém, a utilização de diferentes métodos para a obtenção do saldo de radiação, empregado na estimativa da evapotranspiração, pode conduzir a resultados distintos. O objetivo desse trabalho foi avaliar a influência do método de obtenção do saldo de radiação na comparação de quatro métodos (FAO-Tanque Classe A, FAO-Radiação Solar, Makkink e Hargreaves-Samani) com o método padrão recomendado pela FAO (Penman-Monteith). A pesquisa foi desenvolvida em área experimental do Departamento de Engenharia Rural da FCAV/UNESP, Campus de Jaboticabal, SP, onde foi instalada uma estação meteorológica automatizada e um Tanque Classe A. Por intermédio de um sistema de aquisição de dados foram obtidas medidas da radiação solar global, saldo de radiação, temperatura do ar, umidade relativa do ar e velocidade do vento. Os resultados indicam que as formas de obtenção do saldo de radiação podem alterar a estimativa da evapotranspiração diária obtida pelo método de Penman-Monteith. UNITERMOS: estação meteorológica automatizada, radiação solar, Penman-Monteith TURCO, J. E. P.; FARIA, M. T. de; FERNANDES E. J. INFLUENCE OF NET RADIATION OBTENTION METHOD COMPARED TO THE REFERENCE EVAPOTRANSPIRATION ESTIMATE METHODS 2 ABSTRACT One way to verify the efficiency of evapotranspiration reference (ETo) estimate methods in different conditions is through the comparison to a standard method. However the utilization of several methods to obtain the net radiation using evapotranspiration reference estimate, can end up in different results. The purpose of this paper was to evaluate the influence of the net radiation obtention method compared to four methods (FAO – Class A pan, FAO – Radiation, Makkink and Hargreaves-Samani) to the Penman-Montheith method which is considered a standard method by FAO. The research was carried out at an experimental area of the Rural Engineering Department of FCAV/São Paulo State University, Jaboticabal, SP, Brazil. Global net radiation, air temperature, air relative humidity, and wind speed were obtained using an automated weather station equipped with sensors. The results showed that the net radiation obtaintion methods can alter the daily evapotranspiration estimate obtained by the Penman-Montheith method. KEYWORDS: automated weather station, solar radiation, Penman-Monteith
Three-Dimensional Analysis of Cleft Palate Topology in Newborn Infants with Reference to the Cranial Skeleton
Authors: Bacher Margit , Göz Gernot , Pham Thinh , Bacher Ulrike , Werner Olga , Buchner Peter , Bacher Adelbert 
Published: October 2018

Objective To describe a method of determining the three-dimensional topology of the palatal crest relative to a reproducible anthropomorphic coordinate system in newborn infants with unilateral cleft palate. For this purpose, physical models of the maxilla and face were analyzed by computer morphometry. Design The study was limited to infants referred to the craniofacial center during the first 11 days after birth. Setting The study was performed at a craniofacial center servicing a large geographic area. Participants The method was applied to 12 infants with unilateral cleft lip, alveolus, and palate (eight patients with left-side clefts and four with right-side clefts). Main outcome Measures The three-dimensional topology of the palatal crest referenced to an anthropometric coordinate system was the primary outcome measure. The anthropometric reference system is defined by the tragus points and the midpoint of a line connecting the endocanthia. Results The topology of the maxillary crests of the patients was characterized by considerable variability. The center of the premaxilla as defined by the attachment of the frenulum was frequently displaced by several millimeters from the midsagittal plane. The displacement was to the left in infants with right-side clefts and to the right in infants with left-side clefts. The premaxilla can be rotated by more than 30° relative to the normal position. No significant retroposition of the minor segment as determined by the location of the tuber points was found. Several morphometric anomalies were found to be correlated linearly. Conclusions We propose that the morphologic deviations are in part caused by the neuromotor activity of the tongue and of the interrupted M. orbicularis oris. The data can serve as the starting point for a longitudinal study of craniofacial development in children with cleft palate and for studies on the efficacy of different therapeutic approaches.
Effect of Stimulus Length on Nasalance Scores
Authors: Watterson Thomas , Lewis Kerry E. , Foley-Homan Niamh 
Published: October 2018

Objective Nasalance measures were compared for speech stimuli of four different lengths. Design The standard for comparison was a 44-syllable passage. The 44-syllable passage was compared to a 17-syllable passage, a 6-syllable sentence, and a 2-syllable word. All stimuli were devoid of nasal consonants and were composed only of low pressure consonants and vowels. Setting Academic and clinical craniofacial center. Subjects The subjects were 20 children at risk for velopharyngeal dysfunction and 5 children without history of communication disorder. Main outcome measure(s) The main outcome measures were the nasalance scores associated with speech samples of different lengths. Results The results showed that comparable measures of nasalance can be obtained using stimuli as short as a six-syllable sentence. Both the 17-syllable and the 6-syllable stimulus achieved high criterion validity, indicating that stimuli of that length could be substituted for the longer 44-syllable passage. The two-syllable word, however, had significantly lower criterion validity and could not be used to obtain valid estimates of nasalance. Conclusion Valid assessment of nasalance can be achieved with speech samples as short as six syllables.
The Diamond Vermilion Flap—A New Technique for Vermilion Augmentation in Cleft Lip Repair
Authors: Gur Eyal , Zuker Ronald M. 
Published: October 2018

Objective In most cleft lips patients, the vermilion on the medial aspect of the repair is deficient in height. Not many surgeons have dealt with ways to augment the height of the vermilion at this location. In the unilateral cleft lip, the repair may include the insertion of a small triangular vermilion flap from the cleft side into an incision made for it in the muco–vermilion junction of the noncleft side. We have developed a new technique to further augment the vermilion in incomplete cleft lip patients. Method Vermilion remnants may be present in these patients on the scar tissue between the margins of the cleft. A diamond-shaped vermilion flap based on its attachments to the orbicularis oris muscle may be transposed into the noncleft side to an incision made caudal and parallel to the muco–vermilion border. Then the triangular vermilion flap may be inserted just distal to the island flap. Using this method, the vermilion is augmented and the muco–vermilion line parallels more the white skin roll.
Single–Follicular-Unit Hair Transplantation to Correct Cleft Lip Moustache Alopecia
Authors: Reed Michael L. , Grayson Barry H. 
Published: October 2018

Objective: To present the case of an 18-year-old boy with a cleft lip scar and an obligatory need for facial hair who underwent single–follicular-unit graft hair transplantation that resulted in significant moustache hair restoration in a single procedure. Setting: The surgery was performed in an outpatient private practice setting using oral sedation and local anesthesia. Results: Advances in instrumentation technology and an increased understanding of the anatomical clustering of hair follicles into so-called “follicular units” containing one to six hairs per unit has resulted in a rapid expansion of hair restoration surgery into new areas including female–pattern alopecia, scarring alopecias, and cosmetic surgery scars. These new techniques can be employed to create natural-looking hair lines in front of artificial hair replacement systems; to improve unnatural looking, old “large-plug” hair transplants; and to correct discontinuity of eyebrows and hairlines in patients with congenital facial clefts. Increased awareness is needed to incorporate follicular-unit graft hair transplant surgery into the family of corrective surgery subspecialties.
Labial-Lingual Double Articulations in Speakers with Cleft Palate
Authors: Gibbon Fiona E. , Crampin Lisa 
Published: October 2018

Objective Labial-lingual double articulations (LLDAs) are speech errors involving simultaneous valving at the lips and in the linguapalatal region. This study investigates the frequency of LLDAs occurring for /p/, /b/, and /m/ targets and describes the linguapalatal contact patterns involved in these abnormal articulations. Design A retrospective study involving analysis of articulatory data from all speakers with cleft palate recorded at a research center over a 10-year period. Participants Twenty-seven speakers aged 5 to 62 years (median 11 years) with compensatory speech errors associated with repaired cleft palate. Measures The lingual component of LLDAs was identified using electropalatography (EPG). EPG data were recorded simultaneously with acoustic data. Fifteen bilabial targets (/p/, /b/, /m/) per participant were analyzed. LLDAs were identified in cases where complete linguapalatal constriction (as observed from EPG data) occurred throughout the closure phase of bilabial targets. The labial component of LLDAs was identified from clinical observations of the speakers made during productions of bilabial targets. Results Three speakers (11%) frequently produced LLDAs for bilabial targets. The configuration of tongue-palate contacts involved in the lingual component of the LLDAs differed in each of the three speakers: one speaker had velar constriction, another had alveolar constriction, and the third had simultaneous alveolar-velar constriction. LLDAs did not similarly affect bilabial targets in the three speakers. One speaker produced LLDAs for /p/ and /b/ targets only. Another produced LLDAs for all /m/ targets but inconsistently for /p/ and /b/ targets. The third speaker produced LLDAs for all /b/ targets but inconsistently for /p/ and /m/ targets. Conclusion LLDAs occurred in a minority of speakers investigated. Nevertheless, it is argued that it is important to identify LLDAs for clinical decision making and for research purposes. The results from this study add to current knowledge about abnormal articulations in cleft palate speech, but further research is needed into the precise timing of lip and tongue-palate closures and into the airflow and acoustic characteristics of LLDAs.
Nonsyndromic Cleft Lip with or without Cleft Palate in China: Assessment of Candidate Regions
Authors: Marazita Mary L. , Field L. Leigh , Cooper Margaret E. , Tobias Rose , Maher Brion S. , Peanchitlertkajorn Supakit , Liu You-E 
Published: October 2018

Objective Although Asians have the highest birth prevalence of oral-facial clefts, the majority of gene mapping studies of cleft lip with or without cleft palate (CL/P) have been in European or American Caucasians. Therefore, the objective of this study of Chinese families was to evaluate linkage and association between CL/P and 10 genetic markers in five chromosomal regions that have shown positive results in Caucasians. Setting Families were ascertained through nonsyndromic CL/P surgical pro-bands from hospitals throughout Shanghai, China. Participants Study participants included 671 individuals from 60 families with two or more members affected with oral-facial clefts. Of the 671 total individuals, 145 were affected. Results Ten markers from chromosomes 2, 4, 6, 17, and 19 were assessed (TGFA, MSX1, D4S194, D4S175, F13A1, GATA185H, D17S250, D17S579, D19S49, APOC2). LOD scores were calculated between each of the 10 markers and CL/P as well as model-free statistics of linkage (SimIBD) and association (TDT). None of the markers showed significantly positive LOD scores with CL/P. A significantly positive result (p = .01) was seen using SimIBD for APOC2 on chromosome 19, and a positive TDT result (p = .004) was obtained for D19S49, near APOC2. Conclusions This is the first gene mapping study of CL/P in China. These results indicate that most of the genetic regions with positive results in Caucasian families may not be involved in CL/P found in China, although there is some positive evidence for the candidate region on chromosome 19.
Palate Re-Repair Revisited
Authors: Sommerlad Brian C. , Mehendale Felicity V. , Birch Malcolm J. , Sell Debbie , Hattee Caroline , Harland Kim 
Published: October 2018

Objective: To analyze the results of a consecutive series of palate re-repairs performed using the operating microscope and identify predictive factors for outcome. Design: Prospective data collection, with blind assessment of randomized recordings of speech and velar function on lateral videofluoroscopy and nasendoscopy. Patients: One hundred twenty-nine consecutive patients with previously repaired cleft palates and symptomatic velopharyngeal incompetence (VPI) and evidence of anterior insertion of the levator veli palatini underwent palate re-repairs by a single surgeon from 1992 to 1998. Syndromic patients, those who had significant additional surgical procedures at the time of re-repair (23 patients), and all patients with inadequate pre- or postoperative speech recordings were excluded, leaving a total of 85 patients in the study. Interventions: Palate re-repairs, with radical dissection and retropositioning of the velar muscles, were performed using the operating microscope with intraoperative grading of anatomical and surgical findings. Main Outcome Measures: Pre- and postoperative perceptual speech assessments using the Cleft Audit Protocol for Speech (CAPS) score, measurement of velar function on lateral videofluoroscopy, and assessment of nasendoscopy recordings. Results: There were significant improvements in hypernasality, nasal emission, and nasal turbulence and measures of velar function on lateral videofluoroscopy, with improvement in the closure ratio, velopharyngeal gap at closure, velar excursion, velar movement angle, and velar velocity. Conclusions: Palate re-repair has been shown to be effective in treating VPI following cleft palate repair, both in patients who have not had an intravelar veloplasty and those who have had a previous attempt at muscle dissection and retropositioning. Palate re-repair has a lower morbidity and is more physiological than a pharyngoplasty or pharyngeal flap.
A Histological Study on Experimental Tooth Movement into Bone Induced by Recombinant Human Bone Morphogenetic Protein-2 in Beagle Dogs
Authors: Kawamoto Tatsuo , Motohashi Nobuyoshi , Kitamura Atsushi , Baba Yoshiyuki , Takahashi Koichiro , Suzuki Shoichi , Kuroda Takayuki 
Published: October 2018

Objective The purpose of this preliminary study was to examine experimental tooth movement into newly generated bone induced by recombinant human bone morphogenetic protein-2 (rhBMP-2). Method After extraction of the maxillary first premolars, bone defects were surgically created in eight adult beagle dogs using a 5-mm-diameter trepan bar. According to which material was grafted into the bone defects, animals were divided into the following four groups: (1) the rhBMP-2 group in which rhBMP-2 with a poly [D,L-(lactide-co-glycolide)]/gelatin sponge complex was implanted; (2) the spongiosa group in which spongiosa from the tibia was grafted; (3) the nongrafted group in which no material was embedded; and (4) the control group in which only tooth extraction was performed. The osteoinductive activity of rhBMP-2 and tooth movement into the newly generated bone were examined by histological and morphometric comparisons of each group. Results Considerable new bone formation was observed at the grafted site both in the rhBMP-2 and in the spongiosa groups. The area of generated bone in the rhBMP-2 group was significantly greater than that in the spongiosa group. Newly generated bone, in both the rhBMP-2 and spongisosa groups, showed a similar histological response to orthodontic force as in normal alveolar bone in the control group. However, root resorption occurred on the pressure side in the rhBMP-2 group. Conclusion These results indicated that rhBMP-2 might constitute an alternative material to autogeneous bone grafting for alveolar cleft defects. Further studies regarding tooth movement into generated bone induced by rhBMP-2 are suggested.
Dental Maturity in Children with a Complete Bilateral Cleft Lip and Palate
Authors: Heidbüchel Kiki L.W.M. , Kuijpers-Jagtman Anne M. , Ophof Ricardo , Van Hooft Rian J.M. 
Published: October 2018

Objective: Dental age in children with a bilateral cleft lip and palate (BCLP) was assessed and compared with children without cleft. Design: Dental age was estimated for 74 children with a complete BCLP (54 boys and 20 girls) from 364 orthopantomograms. Nonlinear regression curves were made between 5 and 14 years of age for boys and girls separately. A comparison was made with a sample of Dutch children (91 girls and 90 boys) without oral clefts for three different age groups, namely 5, 9.5, and 14 years of age. Setting: Data collection was carried out at the Cleft Palate Center, University Medical Center Nijmegen (The Netherlands). A sample from the Nijmegen Growth Study was used as a normative sample. Results: At 5 years of age, boys with a BCLP were significantly delayed in dental age compared to boys without cleft. After that age, no significant differences in dental age were found. For girls with a BCLP, no difference in dental age with the girls without cleft could be found. Conclusion: Dental age in BCLP showed a tendency to be delayed at 5 years of age. At the ages of 9.5 and 14 years of age, no differences were found. Further investigation on the development of individual teeth is suggested to gain more insight into the origin of this delay.
Genomic Profiling of Parathyroid Carcinoma Reveals Genomic Alterations Suggesting Benefit from Therapy
Authors: Kang Hyunseok , Pettinga Dean , Schubert Adrian D. , Ladenson Paul W. , Ball Douglas W. , Chung Jon H. , Schrock Alexa B. , Madison Russell , Frampton Garrett M. , Stephens Phil J. , Ross Jeffrey S. , Miller Vincent A. , Ali Siraj M. 
Published: October 2018

Abstract

Background
Parathyroid carcinoma (PC) is a rare endocrine malignancy that can cause life-threatening hypercalcemia. We queried whether comprehensive genomic profiling (CGP) of PC might identify genomic alterations (GAs), which would suggest benefit from rationally matched therapeutics.

Methods
We performed hybrid-capture-based CGP to identify GAs and tumor mutational burden (TMB) in tumors from patients with this malignancy.

Results
There were 85 total GAs in 16 cases (5.3 GAs per case), and the median TMB was 1.7 mutations per megabase (m/Mb), with three cases having &gt;20 m/Mb (18.7%). The genes most frequently harboring GA were CDC73 (38%), TP53 (38%), and MEN1 (31%). All MEN1-mutated cases also had loss of heterozygosity at that locus, but in contrast all CDC73-mutated cases retained heterozygosity. GAs suggesting potential benefit from matched targeted therapy were identified in 11 patients (69%) and most frequently found in PTEN (25%), NF1 (12.5%), KDR (12.5%), PIK3CA (12.5%), and TSC2 (12.5%). A patient whose tumor harbored KDR T668 K and who was treated with cabozantinib experienced a &gt; 50% drop in parathyroid hormone level and radiographic partial response of 5.4 months with duration limited by toxicity.

Conclusion
CGP identified GAs in PC that suggest benefit from targeted therapy, as supported by an index case of response to a matched tyrosine kinase inhibitor. Moreover, the unexpectedly high frequency of high TMB (&gt;20 m/Mb) suggests a subset of PC may benefit from immune checkpoint inhibitors.
Математическое моделирование и расчет процесса деминерализации воды в промышленном фильтре Сообщение 1. Гидродинамика регенерации и отмывки промышленного фильтра
Authors: Галкина Н. К. , Комарова И. В. , Прудковский А. Г. , Хамизов Р. Х. 
Published: October 2018

Изучены технологические особенности работы промышленной ионообменной колонны на примере катионитового фильтра первой ступени центральной обессоливающей установки Новочер-касской ГРЭС. Описана подготовка фильтра к экспериментам и методика их проведения. Экспериментально изучена гидродинамика процессов регенерации и отмывки. Разработаны модель и программа для описания процессов на этих технологических стадиях. Сопоставлением расчетов и экспериментальных данных показано, что гидродинамика этих процессов описывается диффузионной моделью с коэффициентами, определенными нами ранее при стендовых испытаниях.
Математическое моделирование и расчет процесса деминерализации воды в промышленном фильтре Сообщение 3. Влияние стадии взрыхления катионита на процесс регенерации и последующей очистки
Authors: Галкина Н. К. , Комарова И. В. , Прудковский А. Г. 
Published: October 2018

Получены экспериментальные данные по распределению катионов очищаемой воды по слою катионита КУ-2 до и после его взрыхления путем отбора проб на разной высоте работающего ионообменного фильтра. По программе «Createscheme» рассчитаны распределения, которые хорошо совпадают с экспериментальными данными. Показано, что, при взрыхлении происходит полное перемешивание слоя катионита независимо от скорости подачи взрыхляющей воды в исследованном диапазоне скоростей потока
Математическое моделирование и расчет процесса деминерализации воды в промышленном фильтре Сообщение 4. Применение программы «Createscheme» для расчета циклического процесса деминерализации воды
Authors: Галкина Н. К. , Комарова И. В. , Прудковский А. Г. , Хамизов Р. Х. 
Published: October 2018

Рассмотрен циклический процесс сорбции, взрыхления, регенерации и отмывки в промышленном катионитовом фильтре центральной обессоливающей установки Новочеркасской ГРЭС при его длительной эксплуатации. Проведен расчет всех стадий процесса по программе “Createscheme” для каждого цикла. Для одного из 18 экспериментально исследованных циклов представлены расчетные и экспериментальные выходные кривые для иона натрия в середине слоя и на выходе из фильтра.Показано удовлетворительное совпадение расчетного и определенного экспериментально количества колоночных объемов очищенной воды. Совпадение на всех стадиях процесса экспериментальных и расчетных данных свидетельствуют об адекватности предложенных математических моделей промышленному процессу водоподготовки.
Сравнительный анализ методов оценки характеристик молекулярно-массового распределения полиметиленнафталинсульфонатов
Authors: Замуруев О. В. , Вовк А. И. 
Published: October 2018

Для технических полиметиленнафталинсульфонатов, применяемых в строительной промышленности, проведено сопоставление двух хроматографических методов оценки молекулярномассового распределения (ММР): высокоэффективной жидкостной (ВЭЖХ) и гельпроникающей хроматографии (ГПХ). Установлена предпочтительность метода ион-парной ВЭЖХ для получения надежных характеристик.