bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proliferation, apoptosis, and number of Sertoli cells in the Syrian hamster during recrudescence after exposure to short photoperiod†‡
Authors: Martínez-Hernández Jesús , Seco-Rovira Vicente , Beltrán-Frutos Ester , Ferrer Concepción , Serrano-Sánchez María Isabel , Pastor Luis Miguel 
Published: October 2019

AbstractThe Sertoli cell (Sc) has been described as a quiescent cell once the animal has reached sexual maturity. Syrian hamster is an animal that displays testicular regression due to short photoperiod, during which process germ cells and Sc are removed through apoptosis. The aim of this work was to investigate histochemically whether the spontaneous testicular recrudescence processes after exposure to a short photoperiod lead to an increase in Sc proliferative activity in order to restore the normal population. Three spontaneous recrudescence groups were established: initial (IR), advanced (AR), and total (TR) recrudescence, which were compared with animal undergoing the regression process (mild: MRg, strong: SRg, and total: TRg) and animals in long photoperiod (Controls). Histological sections were submitted to histochemical techniques for detecting apoptotic and proliferative Sc with bright-field and fluorescence microscopy. For each group, the proliferative Sc index (PScI) and apoptotic Sc index (AScI), and the total number of Sc were obtained. The results revealed the existence of Vimentin+/TUNEL+ as well as Vimentin+/PCNA+ cells. The PScI was significantly higher in TRg and IR than in the other groups. The AScI was only significantly higher in MRg and SRg with respect to the other groups. The total number of Sc increased among TRg, IR, and AR, reaching values similar to those of the Controls. In conclusion, the increase in Sc proliferation from final regression and recrudescence, accompanied by a similar rate of apoptosis to the Control group, is the cause of the restoration of the Sc population during spontaneous recrudescence.
Intraovarianism. Local mechanisms that affect follicle and luteal dynamics in heifers and women†
Authors: Ginther O J 
Published: October 2019

Abstract
Intraovarianism is represented by greater follicle activity in right ovary (RO) than left ovary (LO) during the two or three follicular waves per interovulatory interval in heifers and the ovulatory wave in women. In each species, selection between the dominant follicle (DF or F1) and future largest subordinate follicle (F2) is manifested by diameter deviation. The RO has more ≥6 mm predeviation follicles in heifers, more 2–10 mm predeviation follicles in women, and greater frequency of ovulation in each species. The RO propensity for ovulation likely develops before birth or at least before sexual maturity as indicated by (1) heavier RO with more follicles in recently born calves and heavier right fetal gonad with more DNA content in humans and (2) greater RO frequency for largest follicle of a wave in sexually immature heifers and for first ovulation of puberty. In heifers, intraovarianism is also expressed by (1) two-way enhancement effect between DF and CL when in same ovary, (2) regression of predeviation follicles when adjacent to the regressing CL, (3) more frequent location of F2 during predeviation in ovary that contains F1, (4) greater diameter increase during recovery of subordinate follicles when in RO with the future DF, and (5) effect of an intraovarian pattern on the pattern in the next wave. The nature of these forms of intraovarianism is not known but may be physical rather than from local passage of factors between structures. Intraovarianism should be considered when studying systemic hormonal effects on ovarian dynamics.
Networked Decisions: Decision-Making Thresholds in Child Protection
Authors: Keddell Emily , Hyslop Ian 
Published: October 2019

AbstractFamilies are significantly affected by decisions made in the child protection context, yet decision outcomes differ even when cases are similar. Understanding the concepts, practices and processes of differentiation that push some cases over the threshold of key decision points, but not other similar cases, is crucial. Drawing on interviews and focus groups with child protection social workers from three site offices in Aotearoa New Zealand (interviews, n = 26; focus groups, n = 25) and using thematic analysis, this study identified the case, internal organisational, inter-site organisational and external elements that contributed to threshold decisions. Case factors such as children’s age, abuse type and chronicity recorded family history and perceptions of family compliance interacted with internal organisational processes and practices, social negotiations and hierarchical power differences to produce decision outcomes. Inter-site differences in decision thresholds resulted from differences in site managers’ perceptions of acceptable case type, site workloads, resources, size and cultural commitment to family preservation. External demographic inequalities were perceived as causing differing levels of site workload. This ‘networked decision-making’ process is theorised drawing on an extended version of the decision-making ecology (DME), by using qualitative methods to examine interactions between the DME elements and their relationship with risk regimes.
Secrecy, spies and the global South: intelligence studies beyond the ‘Five Eyes’ alliance
Authors: Shiraz Zakia , Aldrich Richard J. 
Published: October 2019

Abstract
The study of secrecy and spies remain subjects dominated by Anglo-American experiences. In recent years there has been some effort to refocus the lens of research upon ‘intelligence elsewhere’, including the global South. This is partly because of intense interest in the Arab Spring and ‘managed democracy’, placing a wider range of secret services under the spotlight. However, the approach to research is still dominated by concepts and methods derived from studying the English-speaking states of the ‘Five Eyes’ alliance and their European outriders. This article calls for a re-examination of research strategies for Intelligence Studies and for those theorizing surveillance, suggesting that both fields have much to learn from area studies and development studies, especially in the realm of research practice and ethics. If the growing number of academics specializing in intelligence genuinely wish to move forward and examine the global South they will need to rethink their tool-kit and learn from other disciplines. We suggest there is a rich tradition to draw upon.
The ACS National Surgical Quality Improvement Program—Inflammatory Bowel Disease Collaborative: Design, Implementation, and Validation of a Disease-specific Module
Authors: Eisenstein Samuel , Holubar Stefan D , Hilbert Nicholas , Bordeianou Liliana , Crawford Lynne A , Hall Bruce , Hull Tracy , Hyman Neil , Keenan Megan , Kunitake Hiroko , Lee Edward C , Lewis William D , Maron David , Messaris Evangelos , Miller Reba , Mutch Matthew , Ortenzi Gail , Ramamoorthy Sonia , Smith Radhika , Steinhagen Randolph M , Wexner Steven D 
Published: October 2019

AbstractBackgroundSurgery for inflammatory bowel disease (IBD) involves a complex interplay between disease, surgery, and medications, exposing patients to increased risk of postoperative complications. Surgical best practices have been largely based on single-institution results and meta-analyses, with multicenter clinical data lacking. The American College of Surgeons National Surgical Quality Improvement Project (ACS-NSQIP) has revolutionized the way in which large-volume surgical outcomes data have been collected. Our aim was to employ the ACS-NSQIP to collect disease-specific variables relevant to surgical outcomes in IBD.Study DesignA collaborative of 13 high-volume IBD surgery centers was convened to collect 5 IBD-specific variables in NSQIP. Variables included biologic and immunomodulator medications usage, ileostomy utilization, ileal pouch anastomotic technique, and colonic dysplasia/neoplasia. A sample of the Surgical Clinical Reviewer collected data was validated by a colorectal surgeon at each institution, and kappa's agreement statistics generated.ResultsOver 1 year, data were collected on a total of 956 cases. Overall, 41.4% of patients had taken a biologic agent in the 60 days before surgery. The 2 most commonly performed procedures were laparoscopic ileocolic resections (159 cases) and subtotal colectomies (151 cases). Overall, 56.8% of cases employed an ileostomy, and 134 ileal pouches were constructed, of which 92.4% used stapled technique. A sample of 214 (22.4%) consecutive cases was validated from 8 institutions. All 5 novel variables were shown to be reliably collected, with excellent agreement for 4 variables (kappa ≥ 0.70) and very good agreement for the presence of colonic dysplasia (kappa = 0.68).ConclusionWe report the results of the initial year of implementation of the first disease-specific collaborative within NSQIP. The selected variables were demonstrated to be reliably collected, and this collaborative will facilitate high-quality, large case–volume research specific to the IBD patient population.
A Pilot Trial of Online Training for Family Well-Being and Veteran Treatment Initiation for PTSD
Authors: Erbes Christopher R , Kuhn Eric , Polusny Melissa A , Ruzek Josef I , Spoont Michele , Meis Laura A , Gifford Elizabeth , Weingardt Kenneth R , Campbell Emily Hagel , Oleson Heather , Taylor Brent C 
Published: October 2019

Abstract

Introduction
Family members are important supports for veterans with Posttrauamtic Stress Disroder (PTSD), but they often struggle with their own distress and challenges. The Veterans Affairs—Community Reinforcement and Family Training (VA-CRAFT) website was designed to teach family members of veterans with PTSD effective ways to interact with their veterans to encourage initiation of mental health services as well as to care for themselves and improve their relationships. This article presents a pilot investigation of VA-CRAFT.

Materials and Method
Spouse/partners of veterans who had screened positive for PTSD but were not in mental health treatment were randomized to either use the VA-CRAFT website (n = 22) or to a waitlist control condition (n = 19) for 3 months. Veteran mental health service initiation was assessed posttreatment. Spouse/partner distress, caregiver burden, quality of life, and relationship quality were assessed pre and posttreatment. The study was approved by the Minneapolis VA Health Care System Institutional Review Board (IRB).

Results
Differences between groups on veteran treatment initiation were small (Phi = 0.17) and not statistically significant. VA-CRAFT participants reported large and statistically significantly greater decreases in overall caregiver burden (η2 = 0.10) and objective caregiver burden (η2 = 0.14) than control participants. Effects were larger for those with greater initial distress. Effects sizes for other partner outcomes were negligible (η2 = 0.01) to medium (η2 = 0.09) and not statistically significant. Postintervention interviews suggested that only 33% of the VA-CRAFT participants talked with their veterans about starting treatment for PTSD during the trial.

Conclusion
Results from this pilot trial suggest that VA-CRAFT holds initial promise in reducing caregiver burden and as such it could be a useful resource for family members of veterans with PTSD. However, VA-CRAFT does not enhance veteran treatment initiation. It may benefit from enhancements to increase effectiveness and caregiver engagement.
Abdominal Insufflation Is Associated With Increase of Intracranial Pressure in Patients With Normal Pressure Hydrocephalus
Authors: Bunevicius Adomas , Vernon Ashley , Golby Alexandra 
Published: October 2019

Abstract

BACKGROUND
Ventriculoperitoneal shunting (VPS) is effective for the treatment of normal-pressure hydrocephalus (NPH) and sometimes requires laparoscopic assistance with abdominal insufflation.

OBJECTIVE
To evaluate the association of abdominal insufflation with opening pressure (OP) in NPH patients undergoing VPS implantation.

METHODS
Between March 2016 and April 2019, 52 consecutive patients who underwent first-time VPS implantation surgery were retrospectively identified by reviewing electronic health records. OP during the large volume lumbar tap test (OPLP) and VPS implantation surgery (OPSURGERY) were measured in 29 patients.

RESULTS
Laparoscopic assistance with abdominal insufflation was used in 20 (69%) cases. There were no differences in patient age (P = .589), gender (P = .822), body mass index (P = .289), weight (P = .789), height (P = .542), and OPLP (P = .476) in patients operated with and without laparoscopic assistance. When compared to patients operated without laparoscopic assistance, laparoscopic assistance was associated with a greater rate of OP increase during surgery relative to OPLP (40% vs 100%, P = .002), a greater increase in OPSURGERY relative to OPLP (−0.40 ± 5.38 vs 10.17 ± 5.53 cm H2O, P < .001), and a greater proportion of patients with OPSURGERY of ≥25 cm H2O during the VPS surgery (0% vs 78%, P < .001).

CONCLUSION
Abdominal insufflation is associated with an increase in intracranial pressure with OPs often exceeding 25 cm H2O. This should be considered when selecting optimal VPS pressure settings.
Equity Price Discovery with Informed Private Debt
Authors: Addoum Jawad M , Murfin Justin R 
Published: October 2019

AbstractEquity markets fail to account for the value-relevant nonpublic information enjoyed by syndicated loan participants and reflected in publicly posted loan prices. A long-short strategy that buys (sells) the equities of firms with recently appreciated (depreciated) loans earns large risk-adjusted returns, suggesting a surprising and economically important level of segmentation across the same firm’s capital structure. The information lag captured by trading strategy returns is not affected by drivers of firm-specific attention, including the publication of loan returns in the Wall Street Journal. Instead, returns to the strategy are eliminated among equities held by mutual funds also trading in syndicated loans.Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
A Novel Association of Martorell Ulcer With Liddle Syndrome
Authors: Malphrus Elizabeth , Couch Kara , Chao Jerry W. 
Published: October 2019

ABSTRACT
Pseudohyperaldosteronism, or Liddle syndrome, is a rare, autosomal dominant condition characterized by early-onset hypertension, often associated with hypokalemia and metabolic alkalosis. Martorell hypertensive ischemic leg ulcer is a rare, underdiagnosed ulcer characterized by subcutaneous arteriolosclerosis, classically appearing over the dorsolateral lower extremity or Achilles tendon in patients with hypertension and diabetes. It presents an important diagnostic challenge because it can appear grossly similar to other entities such as pyoderma gangrenosum or venous stasis ulcers, but requires surgical intervention. This article presents a case study of surgical management of a Martorell ulcer in a 69-year-old woman with Liddle syndrome. To the authors’ knowledge, this is the first case reported in the literature of this rare ulcer occurring secondary to this rare cause of hypertension.
Continuity With Patients, Preceptors, and Peers Improves Primary Care Training: A Randomized Medical Education Trial
Authors: Henschen Bruce L. , Liss David T. , Golden Blair P. , Cameron Kenzie A. , Bierman Jennifer A. , Ryan Elizabeth R. , Gard Lauren A. , Neilson Eric G. , Wayne Diane B. , Evans Daniel B. 
Published: October 2019

Purpose
Infusing continuity of care into medical student clerkships may accelerate professional development, preserve patient-centered attitudes, and improve primary care training. However, prospective, randomized studies of longitudinal curricula are lacking.

Method
All entering Northwestern University Feinberg School of Medicine students in 2015 and 2016 were randomized to the Education Centered Medical Home (ECMH), a 4-year, team-based primary care clerkship; or a mentored individual preceptorship (IP) for 2 years followed by a traditional 4-week primary care clerkship. Students were surveyed 4 times (baseline, M1, M2, and M3 year [through 2018]); surveys included the Maslach Burnout Inventory (MBI); the Communication, Curriculum, and Culture (C3) survey assessing the hidden curriculum; and the Attitudes Toward Health Care Teams (ATHCT) scale. The authors analyzed results using an intent-to-treat approach.

Results
Three hundred twenty-nine students were randomized; 316 (96%) participated in surveys. Seventy percent of all respondents would recommend the ECMH to incoming first-year students. ECMH students reported a more positive learning environment (overall quality, 4.4 ECMH vs 4.0 IP, P < .001), greater team-centered attitudes (ATHCT scale, 3.2 vs 3.0, P = .007), less exposure to negative aspects of the hidden curriculum (C3 scale, 4.6 vs 4.3, P < .001), and comparable medical knowledge acquisition. ECMH students established more continuity relationships with patients (2.2 vs 0.3, P < .001) and reported significantly higher professional efficacy (MBI-PE, 4.1 vs 3.9, P = .02).

Conclusions
In this randomized medical education trial, the ECMH provided superior primary care training across multiple outcomes compared with a traditional clerkship-based model, including improved professional efficacy.
An Investigation of the Relationship Between COMLEX-USA Licensure Examination Performance and State Licensing Board Disciplinary Actions
Authors: Roberts William L. , Gross Gretta A. , Gimpel John R. , Smith Larissa L. , Arnhart Katie , Pei Xiaomei , Young Aaron 
Published: October 2019

Purpose
Passing the Comprehensive Osteopathic Medical Licensing Examination of the United States (COMLEX-USA) serves as a licensing requirement, yet there is limited understanding between this high-stakes exam and performance outcomes. This study examined the relationship between COMLEX-USA scores and disciplinary actions received by osteopathic physicians.

Method
Data for osteopathic physicians (N = 26,383) who graduated from medical school between 2004 and 2013 were analyzed using multinomial logistic regression to assess the relationship between COMLEX-USA scores and placement into one of 3 disciplinary action categories relative to no action received, controlling for years in practice and gender.

Results
Less than 1% of physicians in this study (n = 187) had a disciplinary action(s). Controlling for all COMLEX-USA levels, years in practice, and gender, higher Level 3 scores were associated with significant decreased odds for all action categories: revoked licensed (odds ratio [OR] = 0.51, 95% confidence interval [CI] 0.36, 0.72; P < .001), imposed limitations to practice (OR = 0.59, 95% CI 0.41, 0.84; P < .01), and other action imposed (OR = 0.48, 95% CI 0.33, 0.69; P < .001), relative to not receiving an action. In these same models, higher Level 2 Performance Evaluation Biomedical/Biomechanical Domain scores decreased the odds for an action that revoked a license (OR = 0.75, 95% CI 0.58, 0.98; P < .05) and imposed limitations to practice (OR = 0.64, 95% CI 0.49, 0.84; P < .001).

Conclusions
These findings provide evidence that the COMLEX-USA delivers useful information regarding the likelihood of a practitioner receiving state board disciplinary actions.
Diagnosis and Treatment of a Benign Pediatric Mandible Tumor
Authors: Joy Matthew T. , Liao Christopher D. , Magdycz William P. , Parulis Albert W. , Thompson James T. 
Published: October 2019

Summary:
Pediatric mandible tumors are rare and generally benign but can be locally aggressive. Diagnosis and treatment involve tumor identification, excision, and subsequent reconstruction. Successful reconstruction should address form and function of the mandible while minimizing morbidity. The authors review the diagnosis and treatment of a benign pediatric mandible tumor and the use of nonvascularized rib graft for mandible reconstruction. The subject of interest is an 8-year-old boy who presented with progressive left-sided facial swelling and examination findings concerning for a mandibular neoplasm. A large bony tumor of the left mandibular ramus and condyle was identified on computed tomography scan. Needle aspiration was performed but was nondiagnostic. The patient underwent en bloc resection and immediate reconstruction utilizing nonvascularized rib graft. Pathologic analysis demonstrated a benign fibro-osseous lesion consistent with fibrous dysplasia, ossifying fibroma, or aneurysmal bone cyst. The patient had excellent recovery of jaw function and resumption of solid diet 5 weeks after reconstruction. Mandibular defects >6 cm in length often require free vascularized bone flaps for reconstruction; however, these procedures can have greater morbidity in the skeletally immature patient. Nonvascularized rib graft is a viable alternative that also allows for reconstruction of the mandibular condyle using the costocartilagenous cap of the harvested rib. The authors present this case as an example of a rare pediatric head and neck tumor and review of the approach to diagnosis and treatment, including special considerations for complex pediatric mandibular reconstruction.
Breast Implant Surfaces and Their Impact on Current Practices: Where We Are Now and Where Are We Going?
Authors: Munhoz Alexandre Mendonça , Clemens Mark W. , Nahabedian Maurice Y. 
Published: October 2019

Summary:
Most commercially available breast implants feature some degree of elastomer surface modifications to increase surface roughness, in part because several clinical series have demonstrated positive outcomes from texturizing. However, the literature shows that textured implants support higher rates of bacterial growth, and there is a clear association between increased bacterial contamination and host response in vivo, such as capsular contracture. Furthermore, the infectious theory related to bacterial contamination has recently been described as a potential cause in the etiology of anaplastic large-cell lymphoma. Recent research has focused on the physiology of breast implant surfaces advances and how they interact with the body, creating new surface technologies which have the potential to affect all aspects of breast surgery. Understanding how surface properties affect inflammatory cell response will be essential in designing implants that can provide an esthetic solution while also minimizing long-term clinical complications. This special topic highlights the current knowledge on silicone implant surfaces, as well as innovations that have shaped and will continue to change the silicone breast implant industry in the future. It also provides an overview of the principal surfaces that exist and may find clinical applications in esthetic and reconstructive breast surgery. As additional advances emerge, objective tools will be required to evaluate the different surfaces available on the market, along with the long-term efficacy of new technologies.