bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time‐Dependent Myocardial Necrosis in Patients With ST‐Segment–Elevation Myocardial Infarction Without Angiographic Collateral Flow Visualized by Cardiac Magnetic Resonance Imaging: Results From the Multicenter STEMI‐SCAR Project
Authors: Greulich Simon , Mayr Agnes , Gloekler Steffen , Seitz Andreas , Birkmeier Stefan , Schäufele Tim , Bekeredjian Raffi , Zuern Christine S. , Seizer Peter , Geisler Tobias , Müller Karin A. L. , Krumm Patrick , Nikolaou Konstantin , Klug Gert , Reinstadler Sebastian , Pamminger Mathias , Reindl Martin , Wahl Andreas , Traupe Tobias , Seiler Christian , Metzler Bernhard , Gawaz Meinrad , Windecker Stephan , Mahrholdt Heiko 
Published: June 2019

Background

Acute complete occlusion of a coronary artery results in progressive ischemia, moving from the endocardium to the epicardium (ie, wavefront). Dependent on time to reperfusion and collateral flow, myocardial infarction (
MI
) will manifest, with transmural
MI
portending poor prognosis. Late gadolinium enhancement cardiac magnetic resonance imaging can detect
MI
with high diagnostic accuracy. Primary percutaneous coronary intervention is the preferred reperfusion strategy in patients with
ST
‐segment–elevation MI with <12 hours of symptom onset. We sought to visualize time‐dependent necrosis in a population with
ST
‐segment–elevation MI by using late gadolinium enhancement cardiac magnetic resonance imaging (STEMI‐SCAR project).

Methods and Results

ST
‐segment–elevation MI patients with single‐vessel disease, complete occlusion with TIMI (Thrombolysis in Myocardial Infarction) score 0, absence of collateral flow (Rentrop score 0), and symptom onset <12 hours were consecutively enrolled. Using late gadolinium enhancement cardiac magnetic resonance imaging, the area at risk and infarct size, myocardial salvage index, transmurality index, and transmurality grade (0–50%, 51–75%, 76–100%) were determined. In total, 164 patients (aged 54±11 years, 80% male) were included. A receiver operating characteristic curve (area under the curve: 0.81) indicating transmural necrosis revealed the best diagnostic cutoff for a symptom‐to‐balloon time of 121 minutes: patients with >121 minutes demonstrated increased infarct size, transmurality index, and transmurality grade (all
P
<0.01) and decreased myocardial salvage index (
P
<0.001) versus patients with symptom‐to‐balloon times ≤121 minutes.

Conclusions

In MI with no residual antegrade and no collateral flow, immediate reperfusion is vital. A symptom‐to‐balloon time of >121 minutes causes a high grade of transmural necrosis. In this pure
ST
‐segment–elevation MI population, time to reperfusion to salvage myocardium was less than suggested by current guidelines.
Angioedema in Stroke Patients With Thrombolysis
Authors: Fröhlich Kilian , Macha Kosmas , Gerner Stefan T. , Bobinger Tobias , Schmidt Manuel , Dörfler Arnd , Hilz Max J. , Schwab Stefan , Seifert Frank , Kallmünzer Bernd , Winder Klemens 
Published: June 2019

Background and Purpose—
Oral angioedema (OA) is a rare but life-threatening complication in patients with ischemic stroke receiving intravenous thrombolysis with r-tPA (recombinant tissue-type plasminogen activator). This study intended to determine associations between thrombolysis-related OA and ischemic stroke lesion sites using a voxel-wise lesion analysis.

Methods—
Prospective registry data were used to identify ischemic stroke patients with thrombolysis-related OA between 2002 and 2018. For the study registry, ethics approval was obtained by the Ethics Committee of the Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg (clinical registry registration: 377_17Bc). Ischemic stroke patients with thrombolysis treatment but without OA admitted in the years 2011 and 2012 comprised the control group. Ischemic lesions were manually outlined on magnetic resonance imaging (1.5T or 3T) or computed tomographic scans and transformed into stereotaxic space. We determined the lesion overlap and compared the absence or presence of OA voxel-wise between patients with and without lesions in a given voxel using the Liebermeister test. Stroke severity was rated using the National Institutes of Health Stroke Scale score, and blood pressure, heart rate, blood glucose levels, and body temperature were determined on admission.

Results—
Fifteen ischemic stroke patients with thrombolysis-related OA were identified. The voxel-wise analysis yielded associations between OA and ischemic lesions in the insulo-opercular region with a right hemispheric dominance. Mean blood pressure was significantly lower in patients with OA than in controls. Age, National Institutes of Health Stroke Scale scores, infarct volumes, heart rate, and blood glucose levels did not differ between patients with and without OA.

Conclusions—
The voxel-wise analysis linked thrombolysis-related OA to right insulo-opercular lesions. The lower blood pressure in patients with thrombolysis-related OA may reflect bradykinin effects causing vasodilatation and increasing vascular permeability.
Serum Ngb (Neuroglobin) Is Associated With Brain Metabolism and Functional Outcome of Aneurysmal Subarachnoid Hemorrhage
Authors: Ding Chen-Yu , Kang De-Zhi , Wang Zi-Liang , Lin Yuan-Xiang , Jiang Chang-Zhen , Yu Liang-Hong , Wang Deng-Liang , Lin Zhang-Ya , Gu Jian-Jun 
Published: June 2019

Background and Purpose—
Hypoxic-ischemic brain damage is a well-recognized physiopathologic mechanism after aneurysmal subarachnoid hemorrhage (aSAH). The Ngb (neuroglobin) is a hemoprotein predominantly expressed in the brain with a high affinity for oxygen. Relationship between serum Ngb level and brain metabolism in aSAH patients has not been investigated previously.

Methods—
Thirty-six consecutive severe aSAH patients (Glasgow Coma Scale score ≤8 on admission) with multimodal neuromonitoring and 36 matched healthy subjects were included. Serum Ngb level was analyzed in combination with other time-matched cerebral microdialysis parameters, brain tissue oxygen tension, and 12-month neurological outcomes.

Results—

Serum Ngb level was correlated positively with cerebral microdialysis parameters and brain tissue oxygen tension (
P
<0.001). Poor functional outcome (modified Rankin Scale score >3) 12 months after aSAH was associated with higher Ngb level but independent of age, sex, and disease severity (
P
<0.001). A similar association was found between high Ngb level and neuropsychological test results indicative of impairments in cognition, visual conceptualization, and frontal executive functions (
P
<0.001).

Conclusions—
Ngb may be a potential biomarker for reflecting brain tissue oxygen tension, brain metabolism, and functional outcome in severe aSAH patients and merits further study in the context of aSAH.
Terebellidae (Polychaeta) from Coiba National Park, Panamanian Pacific, including description of four new species and synonymy of the genus Paraeupolymnia with Lanicola
Authors: CAPA MARÍA , HUTCHINGS PAT A. 
Published: June 2019

Four new species of terebellids (Terebellidae, Polychaeta) associated with hard substrates in the Coiba National Park (Panamanian Pacific) are described. The diagnostic features of each species within their respective genera are as follows: Eupolymnia joaoi sp. nov. has an enlarged second pair of lateral lobes, nephridial papillae present on segments 3–8, 14 ventral pads, neuropodial tori with uncini arranged in one single row in segments 5–10, and uncini with two rows of 2–3 teeth each over the main fang; Lanicola guillermoi sp. nov. has prostomial eyespots and a characteristic shape and dental formula of the uncini, with a larger tooth on the first row over the main fang and 3–5 teeth on the second row; Lanicola eduardoi sp. nov. lacks prostomial eyespots and has a characteristic uncinial dental formula on anterior and posterior segments of MF:3:2 and MF:1:1–3, respectively; Thelepus fraggleorum sp. nov. has branchial filaments separated by a wide dorsal gap, a characteristic uncinial dental formula of MF:2:1 on anterior uncini and MF:2–3:1–3 on posterior, and notopodia on more than half of anterior segments. In addition, the status of Terebella gorgonae and Eupolymnia regnans, two species previously recorded from the Panamic Province (Tropical Eastern Pacific), is examined. Descriptions of the syntype of E. regnans and of possible specimens of “Terebella” cf. Terebella gorgonae from the Coiba National Park are provided. The genus Paraeupolymnia is synonymised with Lanicola, and the diagnosis of Lanicola is emended.
A new genus and species of Brychiopontiidae Humes, 1974 (Crustacea: Copepoda:Siphonostomatoida) associated with an abyssal holothurian in the NortheastPacific nodule province
Authors: MAHATMA RADITH , ARBIZU PEDRO MARTÍNEZ , IVANENKO VIATCHESLAV N. 
Published: June 2019

A new genus and species Neobrychiopontius galeronae gen. nov. sp. nov. is described based on female specimens from the Pacific nodule province associated with the abyssal holothurian Oneirophanta cfr. setigera (Ludwig, 1894) (Elasipodida, Deimatidae). The holothurian and copepods were collected at a depth of 4978 m during the cruise “Nodinaut” (Ifremer, 17 May – 28 June 2004) on RV Atalante using a spade corer operated from the submersible Nautile. The new genus has retained a greater number of plesiomorphic characters, when compared to its closest relative the monotypic genus Brychiopontius Humes, 1974 from the abyssal zone of the North Atlantic: proximal 3 segments of antennule articulates (fused in Brychiopontius), well developed mandibular palp and inner lobe of maxilla (both absent in Brychiopontius). On the other hand the new genus has only 2 outer spines on the third exopodal segment of leg 1 (instead of 3 in Brychiopontius). Two plesiomorphic characters hitherto unknown for the order Siphonostomatoida are present in the new genus viz. the inner lobe of the first segment of the maxilla is armed with 2 setae and the first segment of the mandibular palp is armed with 1 seta. Neobrychiopontius galeronae gen. et sp. nov. is the second species of Siphonostomatoida found in association with abyssal holothurians (both belonging to the genus Oneirophanta) and represents the first record of the family Brychiopontiidae in the Pacific Ocean.
Modeling the Influence of the Weddell Polynya on the Filchner–Ronne Ice Shelf Cavity
Authors: Naughten Kaitlin A. , Jenkins Adrian , Holland Paul R. , Mugford Ruth I. , Nicholls Keith W. , Munday David R. 
Published: June 2019

ABSTRACT
Open-ocean polynyas in the Weddell Sea of Antarctica are the product of deep convection, which transports Warm Deep Water (WDW) to the surface and melts sea ice or prevents its formation. These polynyas occur only rarely in the observational record but are a near-permanent feature of many climate and ocean simulations. A question not previously considered is the degree to which the Weddell polynya affects the nearby Filchner–Ronne Ice Shelf (FRIS) cavity. Here we assess these effects using regional ocean model simulations of the Weddell Sea and FRIS, where deep convection is imposed with varying area, location, and duration. In these simulations, the idealized Weddell polynyas consistently cause an increase in WDW transport onto the continental shelf as a result of density changes above the shelf break. This leads to saltier, denser source waters for the FRIS cavity, which then experiences stronger circulation and increased ice shelf basal melting. It takes approximately 14 years for melt rates to return to normal after the deep convection ceases. Weddell polynyas similar to those seen in observations have a modest impact on FRIS melt rates, which is within the range of simulated interannual variability. However, polynyas that are larger or closer to the shelf break, such as those seen in many ocean models, trigger a stronger response. These results suggest that ocean models with excessive Weddell Sea convection may not be suitable boundary conditions for regional models of the Antarctic continental shelf and ice shelf cavities.
Can We Detect Submesoscale Motions in Drifter Pair Dispersion?
Authors: Essink Sebastian , Hormann Verena , Centurioni Luca R. , Mahadevan Amala 
Published: June 2019

AbstractA cluster of 45 drifters deployed in the Bay of Bengal is tracked for a period of four months. Pair dispersion statistics, from observed drifter trajectories and simulated trajectories based on surface geostrophic velocity, are analyzed as a function of drifter separation and time. Pair dispersion suggests nonlocal dynamics at submesoscales of 1–20 km, likely controlled by the energetic mesoscale eddies present during the observations. Second-order velocity structure functions and their Helmholtz decomposition, however, suggest local dispersion and divergent horizontal flow at scales below 20 km. This inconsistency cannot be explained by inertial oscillations alone, as has been reported in recent studies, and is likely related to other nondispersive processes that impact structure functions but do not enter pair dispersion statistics. At scales comparable to the deformation radius LD, which is approximately 60 km, we find dynamics in agreement with Richardson’s law and observe local dispersion in both pair dispersion statistics and second-order velocity structure functions.
Forecasting the 8 May 2017 Severe Hail Storm in Denver, Colorado, at a Convection-Allowing Resolution: Understanding Rimed Ice Treatments in Multimoment Microphysics Schemes and Their Effects on Hail Size Forecasts
Authors: Labriola Jonathan , Snook Nathan , Xue Ming , Thomas Kevin W. 
Published: June 2019

AbstractDay-ahead (20–22 h) 3-km grid spacing convection-allowing model forecasts are performed for a severe hail event that occurred in Denver, Colorado, on 8 May 2017 using six different multimoment microphysics (MP) schemes including: the Milbrandt–Yau double-moment (MY2), Thompson (THO), NSSL double-moment (NSSL), Morrison double-moment graupel (MOR-G) and hail (MOR-H), and Predicted Particle Properties (P3) schemes. Hail size forecasts diagnosed using the Thompson hail algorithm and storm surrogates predict hail coverage. For this case hail forecasts predict the coverage of hail with a high level of skill but underpredict hail size. The storm surrogate updraft helicity predicts the coverage of severe hail with the most skill for this case. Model data are analyzed to assess the effects of microphysical treatments related to rimed ice. THO uses diagnostic equations to increase the size of graupel within the hail core. MOR-G and MOR-H predict small rimed ice aloft; excessive size sorting and increased fall speeds cause MOR-H to predict more and larger surface hail than MOR-G. The MY2 and NSSL schemes predict large, dense rimed ice particles because both schemes predict separate hail and graupel categories. The NSSL scheme predicts relatively little hail for this case; however, the hail size forecast qualitatively improves when the maximum size of both hail and graupel is considered. The single ice category P3 scheme only predicts dense hail near the surface while above the melting layer large concentrations of low-density ice dominate.
Geopoetics, Geopolitics, and Violence: (Un)Mapping Daniel Alarcón’s Lost City Radio
Authors: Mitchell Tamara L. 
Published: June 2019

Daniel Alarcón’s 2007 novel Lost City Radio positions post-civil-conflict Peru in relation to episodes of violence from across the globe by deploying two opposing cartographic impulses. First, the unnamed fictional nation of the novel shares historical, topographical, and sociopolitical traits with modern Peru. At the same time, the text refuses tidy association with Peru, principally by folding violent conflicts from a host of geopolitical spaces into the fictional nation via journalistic ekphrasis. This results in a unique geopoetics that serves to catalyze the localized reality of postconflict Peru as a means of interrogating the efficacy of human rights discourse in the neoliberal era on a global scale and bringing into focus the current inequity of responses to the global refugee crisis. En la novela Lost City Radio (2007) de Daniel Alarcón, el Perú de la posguerra se representa en relación con episodios de violencia de diversos países a través de dos impulsos cartográficos contradictorios. La nación ficticia (sin nombre) comparte rasgos históricos, topográficos y sociopolíticos con el Perú contemporáneo. A la vez, la novela no permite asociación simple con el Perú al incorporar conflictos violentos en diversos espacios geopolíticos a través de la écfrasis periodística. El resultado es una geopoética única que sirve para catalizar la realidad local del Perú de la posguerra con fin de interrogar la eficacia del discurso de los derechos humanos en la época neoliberal a escala global y puntualizar la crisis global de refugiados.
Unilateral vs Bilateral Supraglottoplasty: A Meta‐analysis of Rates of Return to Surgery and Supraglottic Stenosis
Authors: Avillion Michael P. , Neighbors Cindy Lee P. , Biello Andrew , Anderson Lauren C. , Liming Bryan J. , Camacho Macario 
Published: June 2019

ObjectiveTo perform a systematic review with meta‐analysis of data to determine the rates of repeat surgery and supraglottic stenosis in unilateral versus bilateral supraglottoplasty for laryngomalacia.Data SourcesPubMed/Medline, Cochrane Central, Scopus, Google Scholar, Web of Science, and Embase.Review MethodsDatabases were searched through January 30, 2018. Studies with unilateral or bilateral supraglottoplasty techniques for laryngomalacia were included. The need for repeat (revision or completion) surgery and rates of supraglottic stenosis were primary outcomes. Data were substratified and a meta‐analysis performed.ResultsA total of 251 articles were reviewed, and 20 articles met inclusion criteria (1186 patients: 663 bilateral, 523 unilateral). Regarding the need to return to surgery, the rate of revision for bilateral surgery was 4.1%, compared to the revision and combined revision/completion rates for unilateral surgery which respectively were 1.1% (odds ratio [OR] 0.27; 95% CI 0.11‐0.67; P =. 002) and 18.0% (OR 5.16; 95% CI 3.31‐8.06; P <. 0001). The unilateral versus bilateral supraglottic stenosis rates were 0% versus 1.2% (P =. 011).ConclusionUnilateral supraglottoplasty has a significantly higher rate of repeat surgery, mainly attributed to contralateral surgery, when compared with bilateral supraglottoplasty. There is a small but statistically significant risk of supraglottic stenosis in bilateral procedures. The benefit of a unilateral procedure should be weighed against the cost of subjecting patients to a 4‐fold increased risk of repeat surgery.
Rates of Dysphagia‐Related Diagnoses in Long‐Term Survivors of Head and Neck Cancers
Authors: Aylward Alana , Abdelaziz Sarah , Hunt Jason P. , Buchmann Luke O. , Cannon Richard B. , Lloyd Shane , Hitchcock Ying , Hashibe Mia , Monroe Marcus M. 
Published: June 2019

ObjectiveTo estimate long‐term prevalence of new dysphagia‐related diagnoses in a large cohort of head and neck cancer survivors.Study DesignRetrospective cohort.SettingPopulation based.Subjects and MethodsIn total, 1901 adults diagnosed with head and neck cancer between 1997 and 2012 with at least 3 years of follow‐up were compared with 7796 controls matched for age, sex, and birth state. Prevalence of new dysphagia‐related diagnoses and procedures and hazard ratio compared to controls were evaluated in patients 2 to 5 years and 5 years and beyond after diagnosis. Risk factors for the development of these diagnoses were analyzed.ResultsPrevalence of new diagnosis and hazard ratio compared to controls remained elevated for all diagnoses throughout the time periods investigated. The rate of aspiration pneumonia was 3.13% at 2 to 5 years, increasing to 6.75% at 5 or more years, with hazard ratios of 9.53 (95% confidence interval [CI], 5.08‐17.87) and 12.57 (7.17‐22.04), respectively. Rate of gastrostomy tube placement increased from 2.82% to 3.32% with hazard ratio remaining elevated from 51.51 (13.45‐197.33) to 35.2 (7.81‐158.72) over the same time period. The rate of any dysphagia‐related diagnosis or procedure increased from 14.9% to 26% with hazard ratio remaining elevated from 3.32 (2.50‐4.42) to 2.12 (1.63‐2.75). Treatment with radiation therapy and age older than 65 years were associated with increased hazard ratio for dysphagia‐related diagnoses.ConclusionOur data suggest that new dysphagia‐related diagnoses continue to occur at clinically meaningful levels in long‐term head and neck cancer survivors beyond 5 years after diagnosis.
Influence of Socioeconomic Status on Stage at Presentation of Laryngeal Cancer in the United States
Authors: Lebo Nicole L. , Khalil Diana , Balram Adele , Holland Margaret , Corsten Martin , Ted McDonald James , Johnson‐Obaseki Stephanie 
Published: June 2019

ObjectiveIdentify socioeconomic predictors of stage at diagnosis of laryngeal cancer in the United States.Study DesignRetrospective analysis of the North American Association of Central Cancer Registries’ Incidence Data–Cancers in North America Deluxe Analytic File for expanded races.SettingAll centers reporting to the US Centers for Disease Control and Prevention’s National Program of Cancer Registries.Subjects and MethodsAll cases of laryngeal cancer in adult patients from 2005 to 2013 were reviewed. Ordinal logistic regression models were used to evaluate odd ratios (ORs) for socioeconomic indicators potentially predictive of advancing American Joint Committee on Cancer stage at diagnosis.ResultsA total of 72,472 patients were identified and included. Analysis revealed significant correlation between advanced stage at diagnosis and: Medicaid insurance, lack of insurance, female sex, older age, black race, and certain states of residence. The strongest predictor of advanced stage was lack of insurance (OR, 2.212; P <. 001; 95% CI, 2.035‐2.406). The strongest protective factor was residing in the state of Utah (OR, 0.571; P <. 001; 95% CI, 0.536‐0.609). Once adjusted for regional price and wage disparities, relative income was not a significant predictor of stage at presentation across multiple analyses.ConclusionMultiple socioeconomic factors were predictive of severity of disease at presentation of laryngeal cancer in the United States. This study demonstrated that insurance type was strongly predictive, whereas relative income had surprisingly little influence.