bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning to see the familiar: Technological assemblages in a higher education (non)classroom setting
Authors: Bell Adam , Taylor Katie Headrick , Riesland Erin , Hays Maria 
Published: May 2019

AbstractIf an objective of public higher education is to engage with a diversity of communities, then coursework should be less insulated within classrooms. This work describes and analyzes a university course design that supports undergraduate students to experience learning as relational and transformational via Site Visits within various communities. We focus on “technological assemblages” as a way to understand students’ reorientation to the process and purpose of learning (and teaching). We analyze experiences within the course as momentsof disorientation, reassembly and stabilizationin which students use their mobile devices, bodies and interactions‐in‐place to understand familiar locations as socially and historically contingent sites of learning (and teaching). We argue that this instructional model does important work of putting students at the nexus of building relationships between the university and other community settings around the city.
Androgen receptor (AR) splice variant 7 and full‐length AR expression is associated with clinical outcome: a translational study in patients with castrate‐resistant prostate cancer
Authors: Del Re Marzia , Crucitta Stefania , Sbrana Andrea , Rofi Eleonora , Paolieri Federico , Gianfilippo Giulia , Galli Luca , Falcone Alfredo , Morganti Riccardo , Porta Camillo , Efstathiou Eleni , van Schaik Ron , Jenster Guido , Danesi Romano 
Published: May 2019

ObjectivesTo investigate if full‐length androgen receptor (AR‐FL) is associated with resistance to androgen receptor (AR)‐directed therapy independently and/or combined with AR splice variant 7 (AR‐V7).Patients and MethodsPlasma samples were prospectively collected from 73 patients with castrate‐resistant prostate cancer before first‐ or second‐line AR‐directed therapy. mRNA was isolated from exosomes and AR‐FL and AR‐V7 were analysed by droplet digital PCR.ResultsAR‐FL was detected in all patients and 22% of them were AR‐V7‐positive at baseline. AR‐FL expression was significantly higher in AR‐V7‐positive vs AR‐V7‐negative patients (P < 0.0001). After stratifying patients by tertile for AR‐FL expression, progression‐free survival (PFS) was 22 vs 18 vs 4 months for lower vs intermediate vs higher tertile, respectively (P = 0.0003). The median PFS and overall survival were significantly longer in AR‐V7‐negative vs AR‐V7‐positive patients (20 vs 4 months, P < 0.0001; not reached vs 9 months, P < 0.0001, respectively).ConclusionsResistance to AR‐directed therapy was associated with the presence of AR‐V7; however, AR‐FL expression may help better refine response and survival of patients to AR‐directed therapy. Both biomarkers, if validated in prospective trials, could be used to select the best treatment strategy.
Forest fragmentation in China and its effect on biodiversity
Authors: Liu Jiajia , Coomes David A. , Gibson Luke , Hu Guang , Liu Jinliang , Luo Yangqing , Wu Chuping , Yu Mingjian 
Published: May 2019

ABSTRACTLand‐use change is fragmenting natural ecosystems, with major consequences for biodiversity. This paper reviews fragmentation trends – historical and current – in China, the fourth largest country on Earth, and explores its consequences. Remote sensing makes it possible to track land‐use change at a global scale and monitor fragmentation of dwindling natural landscapes. Yet few studies have linked fragmentation mapped remotely with impacts on biodiversity within human‐modified landscapes. Recent reforestation programs have caused substantial increases in forest cover but have not stopped fragmentation, because the new forests are mostly monocultures that further fragment China's remnant old‐growth lowland forests that harbour the highest levels of biodiversity. Fragmentation – and associated biodiversity declines – is unevenly distributed in China's forests, being most problematic where agricultural expansion is occurring in the southwest and northeast, serious in the densely populated eastern regions where urbanisation and transport infrastructure are modifying landscapes, but less of a problem in other regions. Analyses of temporal trends show that the drivers of forest fragmentation are shifting from mainly agricultural expansion to urbanisation and infrastructure development. Most of China's old‐growth forests persist in small, isolated fragments from which many native species have disappeared, on land unsuitable for human utilisation. Fragmentation throughout China is likely to have major consequences on biodiversity conservation, but few studies have considered these large‐scale processes at the national level. Our review fills this research gap and puts forward a systematic perspective relevant to China and beyond.
Transforming growth factor beta in human milk and allergic outcomes in children: A systematic review
Authors: Khaleva Ekaterina , Gridneva Zoya , Geddes Donna T. , Oddy Wendy H. , Colicino Silvia , Blyuss Oleg , Boyle Robert J. , Warner John O. , Munblit Daniel 
Published: May 2019

AbstractBackgroundHuman milk (HM) transforming growth factor beta (TGF‐β) is critical for inflammation regulation and oral tolerance promotion. Previous reports suggested that variations in HM TGF‐β levels are associated with allergic outcomes.ObjectiveWe undertook a systematic review (PROSPERO 2017 CRD42017069920) to reassess the evidence on the relationships between HM TGF‐β and allergic outcomes in children.MethodsElectronic bibliographic databases (MEDLINE, EMBASE and Cochrane Library) were systematically searched. Two independent reviewers screened reference lists, extracted the data and assessed risk of bias using the National Institute for Clinical Excellence methodological checklist.ResultsA total of 21 studies were identified. Sixteen studies assessed relationships between HM TGF‐β and risk of eczema; 14, allergic sensitization; nine, wheezing/asthma; six, food allergy; three, allergic rhinitis/conjunctivitis. Five cohorts (5/18, 28%) reported a protective effect of TGF‐β1, while 3 (3/10, 30%) suggested increased risk of allergic outcomes development and 1 (1/10, 10%), a protective effect of TGF‐β2 on eczema. Meta‐analysis was not possible due to significant heterogeneity in methodology, age of outcome assessment and differing statistical approaches. 71% (15/21) of studies carried a high risk of bias.Conclusion and clinical relevanceIn contrast with previous findings, we did not find strong evidence of associations between HM TGF‐β and allergic outcomes. Differences in studies' methodology and outcomes do not allow unconditional rejection or acceptance of the hypothesis that HM TGF‐β influences the risk of allergy development. Future studies on diverse populations employing standardized methods, accurate phenotyping of outcomes and evaluation of the effect of TGF‐β in combination with other HM immune markers, microbiome and oligosaccharides are required.
Disrupted regulation of serpinB9 in circulating T cells is associated with an increased risk for post-transplant skin cancer
Authors: Peters F S , Peeters A M A , van den Bosch T P P , Mooyaart A L , van de Wetering J , Betjes M G H , Baan C C , Boer K 
Published: May 2019

Summary
Cutaneous squamous cell carcinoma (cSCC) is a serious complication after organ transplantation and patients benefit from an early risk assessment. We hypothesized that functional differences in circulating T cells may represent risk factors for post-transplant cSCC development. Here, we analysed genome-wide DNA methylation of circulating T cells of kidney transplant recipients before the clinical onset of cSCC, to identify differences associated with post-transplant cSCC development. This analysis identified higher DNA methylation of SERPINB9, which is an intracellular inhibitor of granzyme B, a protein that induces apoptosis in target cells. High DNA methylation of SERPINB9 in circulating T cells was confirmed in a second patient cohort during recurrent cSCC, indicating that high SERPINB9 methylation represents a persistent risk factor for cSCC development. At the functional level, the inverse correlation between DNA methylation and messenger RNA expression present in non-cSCC patients was absent in the cSCC patients. Also, a significant difference in serpinB9 protein expression between cSCC patients and non-cSCC patients was observed. It was concluded that disturbed regulation of serpinB9 in circulating T cells represents a novel risk factor for post-transplant cSCC in kidney transplant recipients.
A novel homozygous splice‐site variant of NCAPD2 gene identified in two siblings with primary microcephaly: The second case report
Authors: Lin Yunting , Zeng Chunhua , Lu Zhikun , Lin Ruizhu , Liu Li 
Published: May 2019

AbstractHere we describe the second case of primary microcephaly caused by a novel homozygous splice‐site variant at the NCAPD2 gene. The proband was born with microcephaly, and developed intellectual disability. Whole exome sequencing identified a canonical splice‐site variant, c.3477+2T>C, at the NCAPD2 gene. Sanger sequencing showed that the proband and her sibling, a symptomatic fetus, carried a homozygous c.3477+2T>C variant, while the unaffected parents were heterozygous and her younger brother had wild‐type alleles. To date, only one case of primary microcephaly with a homozygous splice‐site pathogenic variant at the NCAPD2 gene has been reported. Our study of two siblings provides additional evidence that NCAPD2 is a causative gene of primary microcephaly. This finding adds new knowledge in the etiology of microcephaly and contributes to more accurate counseling of affected families.
Impact of single‐incision laparoscopic surgery on postoperative analgesia requirements after total colectomy for ulcerative colitis: a propensity‐matched comparison with multiport laparoscopy
Authors: Famiglietti F. , Wolthuis A. M. , De Coster J. , Vanbrabant K. , D'Hoore A. , de Buck van Overstraeten A. 
Published: May 2019

AbstractAimTo compare the requirements for postoperative analgesia in patients with ulcerative colitis after single‐incision versus multiport laparoscopic total colectomy.MethodAll patients undergoing single‐incision or multiport laparoscopic total colectomy as a first stage in the surgical treatment of ulcerative colitis between 2010 and 2016 at the University Hospital of Leuven were included. The cumulative dose of postoperative patient‐controlled analgesia was used as the primary end‐point. A Z‐transformation was performed combining values for patient‐controlled epidural analgesia and patient‐controlled intravenous analgesia, resulting in one hybrid outcome variable. The two groups were matched using propensity scores. Subgroup analysis was performed to analyse the impact of extraction site on postoperative pain.ResultsA total of 81 patients underwent total colectomy for ulcerative colitis (median age 35 years). Thirty patients underwent single‐incision laparoscopy, while 51 patients had a multiport approach. The mean normalized patient‐controlled analgesia dose was significantly lower in patients undergoing single‐incision laparoscopy (−0.33 vs 0.46, P < 0.001). This difference was no longer significant in subgroup analysis for patients with stoma site specimen extraction (P = 0.131). The odds of receiving tramadol postoperatively was 3.66 times lower after single‐incision laparoscopy (P = 0.008). The overall morbidity rate was 32.1% (26/81). The mean Comprehensive Complication Index in single‐incision and multiport laparoscopy group was 18.33 and 21.39, respectively (P = 0.506). Hospital stay was significantly shorter after single‐incision laparoscopic surgery (6.3 days vs 7.6 days, P = 0.032).ConclusionSingle‐incision total colectomy was associated with lower postoperative analgesia requirements and shorter hospital stay, with comparable morbidity. However, the specimen extraction site played a significant role in postoperative pain control.
The Aesthetic Preference for Nature Sounds Depends on Sound Object Recognition
Authors: Van Hedger Stephen C. , Nusbaum Howard C. , Heald Shannon L. M. , Huang Alex , Kotabe Hiroki P. , Berman Marc G. 
Published: May 2019

AbstractPeople across the world seek out beautiful sounds in nature, such as a babbling brook or a nightingale song, for positive human experiences. However, it is unclear whether this positive aesthetic response is driven by a preference for the perceptual features typical of nature sounds versus a higher‐order association of nature with beauty. To test these hypotheses, participants provided aesthetic judgments for nature and urban soundscapes that varied on ease of recognition. Results demonstrated that the aesthetic preference for nature soundscapes was eliminated for the sounds hardest to recognize, and moreover the relationship between aesthetic ratings and several measured acoustic features significantly changed as a function of recognition. In a follow‐up experiment, requiring participants to classify these difficult‐to‐identify sounds into nature or urban categories resulted in a robust preference for nature sounds and a relationship between aesthetic ratings and our measured acoustic features that was more typical of easy‐to‐identify sounds. This pattern of results was replicated with computer‐generated artificial noises, which acoustically shared properties with the nature and urban soundscapes but by definition did not come from these environments. Taken together, these results support the conclusion that the recognition of a sound as either natural or urban dynamically organizes the relationship between aesthetic preference and perceptual features and that these preferences are not inherent to the acoustic features. Implications for nature's role in cognitive and affective restoration are discussed.
Converting FENO by different flows to standard flow FENO
Authors: Lassmann‐Klee Paul G. , Lehtimäki Lauri , Lindholm Tuula , Malmberg Leo Pekka , Sovijärvi Anssi R.A. , Piirilä Päivi Liisa 
Published: May 2019

AbstractIn clinical practice, assessment of expiratory nitric oxide (FENO) may reveal eosinophilic airway inflammation in asthmatic and other pulmonary diseases. Currently, measuring of FENO is standardized to exhaled flow level of 50 ml s−1, since the expiratory flow rate affects the FENO results. To enable the comparison of FENO measured with different expiratory flows, we firstly aimed to establish a conversion model to estimate FENO at the standard flow level, and secondly, validate it in five external populations. FENO measurements were obtained from 30 volunteers (mixed adult population) at the following multiple expiratory flow rates: 50, 30, 100 and 300 ml s−1, after different mouthwash settings, and a conversion model was developed. We tested the conversion model in five populations: healthy adults, healthy children, and patients with COPD, asthma and alveolitis. FENO conversions in the mixed adult population, in healthy adults and in children, showed the lowest deviation between estimated from 100 ml s−1 and measured FENO at 50 mL s−1: −0·28 ppb, −0·44 ppb and 0·27 ppb, respectively. In patients with COPD, asthma and alveolitis, the deviation was −1·16 ppb, −1·68 ppb and 1·47 ppb, respectively. We proposed a valid model to convert FENO in healthy or mixed populations, as well as in subjects with obstructive pulmonary diseases and found it suitable for converting FENO measured with different expiratory flows to the standard flow in large epidemiological data, but not on individual level. In conclusion, a model to convert FENO from different flows to the standard flow was established and validated.
Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells
Authors: Sheng Yaru , Ji Zhongzhong , Zhao Huifang , Wang Jinming , Cheng Chaping , Xu Weimin , Wang Xue , He Yuman , Liu Kaiyuan , Li Li , Voeltzel Thibault , Maguer‐Satta Veronique , Gao Wei‐Qiang , Zhu Helen He 
Published: May 2019

AbstractObjectivesEpigenetic modifiers were important players in the development of haematological malignancies and sensitivity to therapy. Mutations of SET domain‐containing 2 (SETD2), a methyltransferase that catalyses the trimethylation of histone 3 on lysine 36 (H3K36me3), were found in various myeloid malignancies. However, the detailed mechanisms through which SETD2 confers chronic myeloid leukaemia progression and resistance to therapy targeting on BCR‐ABL remain unclear.Materials and methodsThe level of SETD2 in imatinib‐sensitive and imatinib‐resistant chronic myeloid leukaemia (CML) cells was examined by immunoblotting and quantitative real‐time PCR. We analysed CD34+CD38− leukaemic stem cells by flow cytometry and colony formation assays upon SETD2 knockdown or overexpression. The impact of SETD2 expression alterations or small‐molecule inhibitor JIB‐04 targeting H3K36me3 loss on imatinib sensitivity was assessed by IC50, cell apoptosis and proliferation assays. Finally, RNA sequencing and ChIP‐quantitative PCR were performed to verify putative downstream targets.ResultsSETD2 was found to act as a tumour suppressor in CML. The novel oncogenic targets MYCN and ERG were shown to be the direct downstream targets of SETD2, where their overexpression induced by SETD2 knockdown caused imatinib insensitivity and leukaemic stem cell enrichment in CML cell lines. Treatment with JIB‐04, an inhibitor that restores H3K36me3 levels through blockade of its demethylation, successfully improved the cell imatinib sensitivity and enhanced the chemotherapeutic effect.ConclusionsOur study not only emphasizes the regulatory mechanism of SETD2 in CML, but also provides promising therapeutic strategies for overcoming the imatinib resistance in patients with CML.
Impact of the Strategic Role of IT on Explorative and Exploitative Innovation Activities: The Role of Environmental Uncertainty
Authors: Wang Yi , Chen Yang , Wang Nianxin , Nevo Saggi , Kou Gang , Alsaadi Fawaz E. 
Published: May 2019

ABSTRACTWhile numerous studies have examined the relationship between IT and innovation, comparatively few explore IT's contribution to explorative and exploitative innovation activities. A better understanding of the influence of IT's strategic role on exploration and exploitation innovation is critical for tracing the complex IT–innovation relationship. To address this gap, we develop a theoretical model that describes the contingent relationship between IT's strategic role and explorative and exploitative innovation activities. By testing the model using a multisource, matched sample of data from Chinese firms, we find that the IT roles of automation, information, and transformation differentially influence exploration and exploitation, underscoring IT's multifaceted role in organizational innovation activities. Specifically, IT‐enabled transformation positively affects exploration, and IT‐enabled information positively affects both exploration and exploitation. We also evidence the moderating effect of environmental uncertainty in these relationships by uncovering that IT‐enabled automation is negatively related to exploration, whereas IT‐enabled transformation positively affects both explorative and exploitative innovation activities with high environmental uncertainty. Our article contributes to the knowledge in the field by demonstrating the value of a firm's transformative IT investments to develop explorative and exploitative innovation activities in the presence of environmental uncertainty.
The Impact of Online Review Content and Linguistic Style Matching on New Product Sales: The Moderating Role of Review Helpfulness
Authors: Topaloglu Omer , Dass Mayukh 
Published: May 2019

ABSTRACTThis article investigates the moderating role of review helpfulness on the effects of online review content and linguistic style matching on new product sales. Using data from 105,494 online reviews from a popular website, IMDB.com, following 264 movie releases, the article shows that the impact of review style and content on new product sales is contingent upon review helpfulness. In particular, results suggest that linguistic style matching, positive emotion, and cognitive components of online review content significantly impact new product sales when the reviews are deemed helpful by the readers. These findings collectively suggest that online review research benefits from deeper textual analysis that includes review content and linguistic style compared to traditional methods that rely solely on numerical ratings. Also, review helpfulness plays a critical role in consumer decision‐making considering a rapidly increasing amount of online information is now available to consumers.
Influence of impacted canines on the stress distribution during dental trauma with and without a mouthguard
Authors: Firmiano Tainah C. , Oliveira Maiolino T. F. , de Souza João B. , Soares Carlos J. , Versluis Antheunis , Veríssimo Crisnicaw 
Published: May 2019

AbstractBackground/AimMaxillary canines have a high incidence of impaction which may be associated with unexpected damage during maxillofacial trauma. The aim of this study was to evaluate how an impacted canine could influence the stress distribution in the dentoalveolar complex during a simulated impact before and after surgical removal plus the protective effect offered by a mouthguard.Materials and MethodsCross‐sectional finite element models of the central incisor and support structures of a patient with an impacted canine in a transverse position were made using ImageJ and Marc/Mentat software. The following impact conditions were simulated: (a) incisor with impacted canine; (b) incisor with surgical socket after impacted canine extraction; and (c) incisor after bone healing. The impacts were also simulated with a 3 mm custom‐fitted ethylene vinyl acetate mouthguard. A non‐linear dynamic impact finite element analysis was performed in which a rigid object hit the model at 1 m/s. Maximum and minimum principal stresses as well as von Mises stresses were analyzed.ResultsHigher values of compressive and tensile stresses occurred on the cortical bone in the models after impacted canine extraction. The highest stress concentrations in the enamel and dentin structures were observed after bone healing. The mouthguard reduced the stress in the alveolar bone and dental structures.ConclusionsUse of mouthguards during impact reduced the compressive and tensile stresses in the alveolar bone, mainly in the fragile regions of the impacted canine or surgical socket.