bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Physiological Role for a Moonlighting Protein in Lipopolysaccharide-induced Endotoxemia
Authors: Zborek Kirsten , Lee Daniel , Pajakowski Adam , Slack Jacob , Park Joseph , Park June , Schwarz Margaret 
Published: January 2019

Background and Hypothesis: The pathogenesis of Bronchopulmonary Dysplasia (BPD) is multifactorial leading to inflammation. In BPD, Endothelial-Monocyte Activating Polypeptide II (EMAP II, encoded by Aimp1), a moonlighting pro-inflammatory cytokine, is initially found in bronchiolar club cells followed by intra-alveolar GAL-3+ macrophages. Sustained EMAP II mimics BPD, invoking inflammation, alveolar simplification, and macrophage recruitment. Targeted ablation of EMAP II in the recruited macrophages may dampen innate immune response.
Experimental Design: Gender-matched, aged-matched littermate mice with myeloid-cell specific ablation of Aimp1 (Lyz2-Cre;Aimp1flox/flox, denoted as Aimp1Δ/Δ) or without (control) were subjected to lipopolysaccharide (LPS)-endotoxemia. Survival rates of co-housed or singly housed mice were measured over 72 hours following a lethal dose (15 mg/kg). Clinical scores (0-6) based on the integrity of their locomotion, fur, and eyes were assigned every 2 hours. Blood and bone marrow smears, average bodyweights, spleen-weights to bodyweights and liver-weights to bodyweights were analyzed.
Results: There were no baseline differences in bodyweight, spleen weight:bodyweight, liver weight:bodyweight (p-val = 0.42, 0.46, 0.64). Representative bone marrow and blood smears showed no notable difference. Aimp1[Symbol]/[Symbol] male mice co-housed (dose 15 mg/kg) but not singly housed survived longer than their littermates (median survival: hours); Aimp1[Symbol]/[Symbol] female mice showed a survival advantage (median survival: hours) with lower clinical scores than their littermates. The kinetics of NFKBIA/I[Symbol]B degradation was similar between Aimp1[Symbol]/[Symbol] and control peritoneal macrophages in response to LPS, although there was a higher basal amount in Aimp1[Symbol]/[Symbol].
Conclusion and Potential Impact: Aimp1/EMAP II does play a positive feedback role in innate immunity, potentially in a metabolically and gender-specific role of Aimp1 which remain to be explored.
Are signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiforme?
Authors: O'Neal William G. , Lahiri, Ph.D Debomoy K. , Dey, M.D Mahua , Wang Ruizhi 
Published: January 2019

Background: Epidemiological studies suggest an inverse association between cancer and neurodegenerative disorders, including Alzheimer’s disease (AD). AD and cancers, such as glioblastoma multiforme (GBM), are characterized by abnormal but opposing cellular behavior. AD is characterized by accumulation of the processing products of amyloid β (Aβ) and its metabolizing enzymes amyloid precursor protein (APP), β-secretase (or BACE1), and γ-secretase. Our rationale is unraveling cell signaling pathways linking AD and GBM. We hypothesized low-grade gliomas (LGG) and high-grade gliomas (HGG) would have differential expression of neuronal and synaptic markers. Furthermore, protein expression profiles of these markers, APP metabolites, and BACE1 would be different among LGG, HGG, and AD cases.
Experimental Design or project methods: Specific neuronal protein markers (e.g., NSE), presynaptic proteins (e.g., synaptophysin and SNAP25), and post-synaptic proteins (e.g., PSD-95) have been measured in glioma samples. Characterization are done by Western immunoblotting and ELISA. Protein biomarkers will be analyzed in LGG and HGG of biopsy samples, and the results will be compared with brain samples from AD cases.
Results: Using specific primary and secondary antibodies and optimal protein range, we have standardized an immunoblotting procedure to detect our desired proteins in blinded LGG and HGG samples. After unblinding and analyzing results, expression signals will be compared between GBM and AD brain samples.
Conclusion and potential impact: Our results would shed light on diverging and/or shared cell signaling pathways between AD and GBM. In addition, potential impact would be utilizing GBM-derived cultures to test and develop therapeutics for both AD and GBM.
Study of serum levels of CRP and procalcitonin as early marker of sepsis in children with sepsis above neonatal age group
Authors: Kumar Vinaya , Neelannavar Ramesh 
Published: January 2019

Background: Sepsis caused by infection remains a major cause of mortality and morbidity among children. Blood culture though gold standard requires lot of time for diagnosis, hence it’s necessary to rely on early diagnostic markers such as blood counts, micro-ESR, CRP, Procalcitonin. The objective of this study is to evaluate the serum levels of CRP, Procalcitonin as reliable and as early marker of sepsis in pediatric patients above neonatal age group.Methods: Children aged above neonatal age group with clinically suspected sepsis as per the definition given by the International Paediatric sepsis Consensus Conference were selected. Patients were classified as those with sirs, sepsis, severe sepsis and septic shock. Patients were divided into two groups one with culture proven sepsis and the other with non-culture proven sepsis. All patients had CRP, Procalcitonin levels measured at admission and 24hrs after admission. The primary outcome was to determine reliable marker in differentiating between the culture proven and non-culture proven sepsis, and to determine the early marker of sepsis.Results: Total 104 patients formed the study group, of which 42 belonged to SIRS group, 26 were sepsis, 19 were severe sepsis and 17 were septic shock. A total of 36 cases had culture positive. In present study PCT was found to be more reliable marker of sepsis as the sensitivity and specificity of PCT was more than CRP and AUC for PCT was significantly higher than CRP. PCT was found to be early marker as the AUC for CRP at 24hrs was significantly more than AUC for CRP at admission and there was no statistically significant difference between AUC for PCT at admission and 24 hours after admission.Conclusions: Both CRP and PCT levels have favourable test performance but PCT is more reliable. PCT is earlier to rise compared to CRP.
The Effectiveness of Stress Reduction-Based Cognitive Therapy on Perceived Stress and Migraine Symptoms of Women Suffering from Migraine
Authors: Nasab Angham Amin , Yousefian Zahra , Sehatti Marmareh 
Published: January 2019

Background: A headache is considered as one of the most common physical complaints and a type of debilitating neurodegenerative disorder that affects people's social, communicative and occupational tasks. Therefore, this study aimed to investigate the effectiveness of stress reduction-based cognitive therapy on perceived stress and migraine symptoms in women suffering from migraine. The instruments used in this study included the Perceived Stress Questionnaire and Migraine Disability Assessment Questionnaire. The present study data were analyzed using the covariance analysis.
Methods: The present study adopted a pretest-posttest with control group design. The statistical population of the present study included all patients suffering from migraine who went to the medical centers in Tehran in 2017. In this study, convenient sampling and random assignments were used. In fact, amongst the migraine patients, 30 patients were selected through a convenient sampling method that were then randomly assigned to experimental and control groups. The experimental group received an intervention in a three-month period in ten 90-minute sessions, whereas the control group did not receive this intervention during the research process. The patients were randomly assigned to the experimental and control groups.
Results: The results of data analysis showed that stress reduction-based cognitive therapy was effective on perceived stress and migraine symptoms in women suffering from migraine (P-value < 0.001), that is to say, this treatment can reduce perceived stress and migraine symptoms in women suffering from migraine
Conclusion: Based on the findings of this study, it can be concluded that cognitive therapy based on stress reduction can be used as an effective treatment to reduce stress and migraine symptoms in women with migraine
As the study findings revealed, it can be concluded that cognitive therapy based on stress reduction can be used as an effective treatment to reduce stress and migraine symptoms for women suffering from migraine.

Keywords: Cognitive Therapy, Migraine Symptoms, Stress
Investigating Health Literacy of Teachers in Asaluyeh
Authors: Asadian Ali , Sotoudeh Ahmad , Venovel Mojgan Zarei , Moosai Roghaieh 
Published: January 2019

Background: Health literacy is defined as the ability of individuals to read, understand, and act on health-related concepts in order to make healthy decisions. This study was conducted to determine the level of health literacy of teachers in Asaluyeh city, Iran.
Methods: This descriptive study was conducted on 200 teachers who were selected using stratified random sampling method in Asaluyeh in the academic year 2015 - 2016. Health Literacy for Iranian Adults questionnaire (HELIA) was used to measure their health literacy. Data were analyzed by SPSS20 and by using descriptive statistics, one way ANOVA, independent- samples T test, and Pearson correlation coefficient.
Results: The mean age of participants was 30.56 years (SD = 4.5(, 59% of them were male (n = 118) and 41% were female (n = 82). Teachers' health literacy status was in moderate level for 9.6% of participants (n = 99) regarding access to information, for 44.6% of participants (n = 89) regarding information comprehension in, for 68.4% of participants (n = 136) regarding judgment and assessment, and for 68.4% of participants (n = 136) regarding information use. We found that health literacy had a significant relationship with gender and age.
Conclusion: In this study, teachers' health literacy was at moderate level. So, it is necessary to provide effective internet resources and useful sites. We should also conduct health education programs in media such as radio and television to improve health literacy in teachers, especially in more experienced teachers.

Keywords: Health Literacy, Teachers, Asaluyeh city
Relationship of Glass Ceiling and Mental Health with Burnout in Women Working in Khansar and Golpayegan Health Care Networks in 2018
Authors: Bayati Houri , Alavi Azam 
Published: January 2019

Background: Burnout affects people's occupational performance and reduces their efficiency. The present study was conducted to investigate the relationship of glass ceiling and mental health with burnout among women working in Khansar and Golpayegan health care networks.
Methods: The study population of this analytical- correlational study consisted of women working in Khansar and Golpayegan health care networks in 2018.
In order to collect data, 159 women were selected from these health care networks using convenience random sampling. Data collection instruments were General Health Questionnaire, Glass Ceiling Inventory and Burnout Questionnaire.
After collecting the questionnaires and drawing raw data, analysis of the data was performed using descriptive statistics (mean and standard deviation) and inferential statistics (Pearson's correlation coefficient and multiple regression analysis).
Results: Glass ceiling perception was correlated with emotional exhaustion (0.49) and personal accomplishment (-38.8), and mental health with emotional exhaustion (0.54) and personal accomplishment (-0.50) among women employed in Khansar and Golpayegan health care networks (P-value < 0.001). Predictor variables (glass ceiling perception and mental health) could significantly predict emotional exhaustion and personal accomplishment.
The model's coefficient of explanation also showed predictor variables (glass ceiling perception and mental health) could explain 46.2% and 26% of the variation in emotional exhaustion and personal accomplishment in these women.
Conclusion: Given the significant role of glass ceiling perception and mental health in predicting emotional exhaustion and personal accomplishment of employed women, it is suggested that the causative agents of the glass ceiling and damaging ones to mental health in employed women be taken into account to prevent burnout among them.

Keywords: Glass Ceiling, Mental Health, Burnout
A Case Report of Formative and Summative Evaluations of a Graduate Course on Foundations of Health Promotion for Masters of Public Health Students
Authors: Sharma Manoj 
Published: January 2019

Development of foundational skills among masters of public health (MPH) students is challenging with regard to the mastery of delivering health education and health promotion methods. In this case report we documented the conceptualization details and results from the formative and summative evaluations of one foundational course on health promotion implemented at a Southern US University. The course was based on the constructs of a fourth generation framework of multi-theory-model (MTM) of health behavior change that aimed at helping the students to acquire the behaviors needed for imparting the health education and health promotion methods in the real world settings. In formative evaluation, a qualitative assessment is used, whereas, in the summative evaluation both qualitative and quantitative approaches are applied. We used a SWOT framework to conduct this study. Some of the documented strengths of the course included practical applications, interactive learning, and good use of the Canvas platform, group work, and skill building activities. The weaknesses of the course were the difficult nature of the subject and the fact that some presented methods were not clear. Some suggested opportunities for future offerings included having better environmental props, more online participation, and guest speakers. Some threats identified by the students were decrease of enrolment and possible reduction of face-to-face interactions due to online offerings. Overall, the instructor was successful in imparting skills pertaining to the methods for conducting health promotion within public health. The skill building activities and assignments elaborated in this course can be freely replicated for enhancing the learning acumen of MPH students around the world. This case report forms the basis for critical reflection among educators entrusted with designing such courses.

Keywords: Public Health, Health Behavior, Health Education, Health Promotion
Evaluating the Effectiveness and Efficiency of Tax Administration System in Ghana, Case Study of Sunyani Municipal Assembly
Authors: Atuahene Sampson Agyapong , Kong YuSheng , Bentum-Micah Geoffrey 
Published: January 2019

In as much as most countries benefit from external sources of funds and grants, her major reliable source of fund is the one generated internally. In a developing country, taxation is one of the major forces behind which the country can develop. Whiles Ghana Revenue Authority is one of the agencies which can mobilize such funds for the benefit of the nations; it is not easy to find tax payers for assessment and eventually to pay their taxes. This study evaluated the efficiency and effectiveness of the tax administration system of the Ghana Revenue Authority (GRA).
The field of the tax administration is of major importance to any tax system. The research brought to light that there is lack of the characteristics of a good tax system that is equity, certainty, convenience and economy. The legal structure is complex and includes axes - related laws, decrees, and rulings.
Value Chain Analysison Processing Cardava Banana Chips In The Philippines: Luzon Case
Authors: Calica Gigi Bernardo , Lingbawan Karen R. 
Published: January 2019

The study aimed to provide relevant information in terms of costs and income so that more people can be enticed to go into business of banana production and processing. This was conducted in the Philippines particularly Luzon island. Value chain and descriptive analyses were used in the data processing.
Research results showed that the chains for the fresh cardava to wet market and to banana chips chains involved six to eight marketing actors namely: the farmer, consolidator, trucker, wholesaler/trader or wholesaler/retailer, processor, distributor, and retailer and the consumer. All activities from the farm to the market were manually done which resulted to more or less five days to deliver the commodity from the farm to the end user.
The processor received the highest gross margin share of 88.59 percent followed by wholesaler/retailer of banana chips getting around 6.25 percent share of gross margin. The farmer, agent/consolidator and wholesaler/retailer received 2.40 percent, 1.49 percent and 1.27 percent, respectively.
In terms of costs, the processor incurred the highest at P4.25 per kg, the farmer at P4.16 per kg and the agent/consolidator at P2.83 per kg, both wholesaler/retailer for the fresh and processed products incurred lower costs than the other actors. Regarding income, chips wholesaler/retailer received the highest at P14.91 per kg; the processor at P6.26 per kg, and the wholesaler/retailer of fresh cardava, the farmer and the agent/consolidator received low income due to the low price of the commodity which was dependent on its quality.
Fertilizer application and use of postharvest tools to improve quality of produce was recommended to receive higher price.
Factors contributing to effective guidance and counselling services at university of Eswatini
Authors: Tsikati Alfred Fana 
Published: January 2019

The growth from childhood to adulthood is always fraught with difficulties which create a void for effective guidance and counselling. Similarly, University of Eswatini (UNESWA) students face numerous problems that require effective guidance and counselling. The purpose of the study was to identify factors contributing to effective guidance and counselling at UNESWA, Luyengo Campus. The study utilised descriptive correlational research design. Data were collected using a self-administered questionnaire. The instrument was pilot tested with 30 students from Luyengo Campus who were not included in the study. The instrument was found to be 79% reliable. Three experts in counselling from UNIESWA and Ministry of Education and Training validated the instrument for both content and face validity. A sample of 297 was randomly drawn from a population of 1277 students. Data were analysed using descriptive, correlational and multiple regression statistics. Findings revealed that counsellor training contributes most, to effective guidance and counselling services (30.4%). Conclusion drawn is that counsellor training is responsible for effective guidance and counselling. Thus, the study recommends that counsellors must receive training in order to provide effective guidance and counselling services to their clients.
Message from the Editor
Authors: Maree Prof. Dr. Kobus 
Published: January 2019

It is a great honour for us to publish Volume 8, Issue 3, of the Global Journal of Guidance and Counseling: Current Perspectives. The journal welcomes original empirical investigations and literature review articles on current issues in guidance and counseling. The journal is published quarterly and serves as an international platform for discussing new developments in guidance and counselling. The journal focuses on, but is not limited to, the following major fields as they relate to guidance and counseling: child and adolescent counseling, adult and elder counseling, family counseling, school counseling, health counseling, crisis and risk counseling, occupational counseling, industrial counseling, cyber counseling, psychology education, inter-disciplinary approaches to psychology, counseling and guidance, rehabilitation counseling, technology usage in psychology, counseling and guidance, and special education.
A total number of twenty-two (22) manuscripts were submitted for this issue and each paper has been subjected to double-blind peer review process by the reviewers specialized in the related field. At the end of the review process, a total number of eight (8) high quality research papers were selected and accepted for publication.
Aim of this issue is to give the researchers an opportunity to share the results of their academic studies. There are different research topics discussed in the articles. For example, Comparison effectiveness of cognitive-behavioural therapy and relaxation technique on curing premenstrual syndrome Farah Mahmoud. The practice and guidance and counseling in Amhara region Ethiopia. Alebachew Mohammed Legas, Antehun Atanaw Mengistu. A Content Analysis of the Research Articles Written on online-counseling, Eser Ceker. Factors contributing to effective guidance and counselling services at university of Eswatini, Alfred Fana Tsikati. Study upon the Postgraduate Dissertations the Subject of which are Family Involvement in Pre-School Education in Turkey, Nur DemirbaÅŸ Ã‡elik, Aycem Birand. A comparative study of the effectiveness of cognitive-behavioural and common method of family education on the psychological well-being of parents and girl students in secondary programme at western region of Isfahan Province, Iran, Mansour Abdi, Aliasghar Abbasi. Relationship between fatherâ€™s emotional intelligence and marital satisfaction with adolescent self-esteem and mental health, Ali Rasouli, Hassan Heydari, Seyed Ali Alyasin, Mansour Abdi. Causes of bullying in the workplace among primary school teachers of your paper, Tomas Cech, Jana KvintovÃ¡, Simona DobeÅ¡ovÃ¡ Cakirpaloglu
The topics of the next issue will be different. You can make sure that we will be try ing to serve you with our journal to provide a rich knowledge of the field.
We present many thanks to all the contributors who helped us to publish this issue.
Kind regards,
Open-Ended Apps in Kindergarten: Identity Exploration Through Digital Role-Play
Authors: McGlynn-Stewart Monica , Brathwaite Leah , Hobman Lisa , Maguire Nicola , Mogyorodi Emma 
Published: January 2019

This 2-year research study followed 14 kindergarten classrooms in Ontario as they used open-ended tablet applications to support literacy learning. Through multimodal slideshows the children explored identities such as reporter, teacher, and architect during self-initiated role-play. The slideshows they created demonstrated multimodal productions that were longer, more complex, and more varied than their literacy production with traditional literacy tools and practices. Rather than supplanting traditional kindergarten meaning-making practices such as role-play, children folded digital affordances into their play in ways that expanded the range of identities they explored and the tools and practices with which they explored them.