bluuebunny/crossref_metadata_2025_split huggingface dataset:
Christopher Hussey: a bibliographical tribute
Authors: Mordaunt Crook J. 
Published: October 2018

Christopher Hussey CBE MA FSA HONARIBA, who died on 20 March 1970, was the doyen of English architectural historians. By any standards, he was an extraordinarily prolific writer. The high points of his literary career were undoubtedly The Picturesque (1927) - a brilliant ‘essay on a way of seeing’ which opened the eyes of a whole generation; English Country Houses: Early, Mid and Late Georgian (3 vols, 1955-58) - the product of forty years’ research; and The Life of Sir Edwin Lutyens (1950) - a biographical classic written with all the wit and sympathy which its subject deserved. But it was week by week in the pages of Country Life that Hussey built up his reputation. Landscapes, country houses, town houses; medieval cottages, Georgian seats and Victorian public buildings, as well as the new-built classics of the Modern Movement, Hussey described them all. His range was remarkable, and his expository power unfailing. More than anyone it was Hussey who made Country Life, in Lord Runciman's words, ‘the keeper of the architectural conscience of the nation'. Of course he travelled a royal road: Scotney Castle, Eton and Christ Church. But he put these inherited advantages to excellent use, delighting in the appreciation of architecture by a wider and wider audience. His whole life was really a triumphant vindication of the English amateur tradition. During his lifetime architectural history was transformed from a species of belles lettres into a serious academic discipline. Almost accidentally, Hussey played a crucial part in this process. Rather more consciously, he helped to turn preservation from a minority cult into a major national concern.(J.M.C., RIBA Jnl., June 1970)
The effect of morphosyntactic training on multilingual fifth graders’ spelling in French
Authors: BÎLICI NATALIA , UGEN SONJA , FAYOL MICHEL , WETH CONSTANZE 
Published: October 2018

ABSTRACTMany studies show that it is challenging to encode morphosyntactic information while writing. Spelling plurals is especially demanding in French as these are inaudible. Even by the end of primary school, monolingual French pupils still have difficulties marking plurals of some grammatical categories. We investigate (1) how multilingual pupils learning French as a second written language deal with silent plural markers and (2) the effects of a morphosyntactic training explicitly focussing on grammatical categories and their markers, as well as visualizing the plural agreement. 228 fifth graders were quasi-randomly assigned to an intervention (n = 137) and a control group (n = 91) based on the results of a spelling pre-test. The results of the pre-test show that multilingual learners have similar spelling patterns as French monolinguals. They pluralize nouns more accurately than verbs and perform lowest on adjectives. After the pre-test, both groups were trained over six sessions of 20 minutes. The control group participated in French listening comprehension activities. The post-test shows that the intervention group significantly improved in spelling plurals compared to the control group. A greater focus on morphosyntactic structures is highly effective especially in second language contexts where children might lack broad lexical knowledge.
Paediatric pulmonary hypertension caused by an ACVRL1 mutation presenting as Ortner syndrome
Authors: Alsheikh Batool , Aljohani Othman , Coufal Nicole G. 
Published: October 2018

AbstractWe report a rare aetiology of vocal cord paralysis secondary to undiagnosed severe pulmonary hypertension from a de novo ACVRL1 variant identified by whole-genome sequencing. The patient had a partial response to intravenous treprostinil in addition to inhaled nitric oxide, bosentan, and sildenafil.
Economic integration and state capacity
Authors: Bruszt Laszlo , Campos Nauro F. 
Published: October 2018

AbstractWe investigate whether and how economic integration increases state capacity. This important relationship has not been studied in detail so far. We put together a conceptual framework that highlights what we call the Montesquieu, Weber and Smith channels to guide our analysis. Each of these corresponds to a series of mechanisms in three distinct institutional arenas: judiciary, bureaucracy and competition policy. To test our framework, we introduce a new panel of institutional reform measures that allow us to investigate how changes in these three arenas interact with each other and what sequence of changes yields increases in state capacity. The yearly data set covers all the 17 candidate countries to join the European Union (EU) after the 1995 enlargement. Deep integration, we find, can induce broad institutional change by providing incentives for simultaneous change in core state institutions. Bureaucratic independence and judicial capacity seem to be the key engine of the process engendered by the prospect of EU membership. Yet early and abrupt removal of external anchors might generate significant backsliding, or reversals, in domestic institutional change.
Spatial trends in United States tornado frequency
Authors: Gensini Vittorio A. , Brooks Harold E. 
Published: October 2018

AbstractSevere thunderstorms accompanied by tornadoes, hail, and damaging winds cause an average of 5.4 billion dollars of damage each year across the United States, and 10 billion-dollar events are no longer uncommon. This overall economic and casualty risk—with over 600 severe thunderstorm related deaths in 2011—has prompted public and scientific inquiries about the impact of climate change on tornadoes. We show that national annual frequencies of tornado reports have remained relatively constant, but significant spatially-varying temporal trends in tornado frequency have occurred since 1979. Negative tendencies of tornado occurrence have been noted in portions of the central and southern Great Plains, while robust positive trends have been documented in portions of the Midwest and Southeast United States. In addition, the significant tornado parameter is used as an environmental covariate to increase confidence in the tornado report results.
Visualization research on the influence of an ultrasonic degassing system on the operation of a hydraulic gear pump
Authors: Antoniak Piotr , Stryczek Jarosław , Banaś Michał , Lyhovskyi Oleksandr , Gryshko Ihor , Zilinskyi Andrii , Kovalov Vasyl 
Published: October 2018

Gear pumps make a group of the most popular hydraulic energy generators. Research and development works concerning those units have been going on for decades, and thanks to them gear pumps feature very good operating parameters. However, even well-designed gear pumps will not work properly if the physical properties of the working fluid are incorrect. One of such properties is compressibility of the fluid, which largely depends on the amount of gas dissolved in the medium. For this reason, the aim is to reduce the amount of gas dissolved in the working medium. It can be done using both chemical and physical methods. Because chemical methods can affect the chemical composition of the working fluid, it is the physical methods that are usually used in hydraulic systems.
This paper presents preliminary visualization research into the influence of an ultrasonic degassing system on the operation of a hydraulic gear pump. Apart from that, operation of such a system and its theoretical impact on the work of the gear pump is discussed Experimental study, using a high-speed camera, was carried out in order to verify the theoretical description.
A new approximate model of tyre accounting for both deformed state and dry friction forces in the contact spot on the background of the coupled model
Authors: Kireenkov Alexey A. , Nushtaev Dmitry V. , Zhavoronok Sergey I. 
Published: October 2018

A new approximate model of the tire rolling accounting for coupled longitudinal and lateral sliding as well as the spinning and the deformed state resulting in elastic forces is proposed. The main goal of this investigation consists in the construction of simple models with a few of degrees of freedom allowing one to implement them analytically in the engineering practice, primarily for the estimation of the rolling stability and for the prognosis of the instable rolling so-called ”shimmy phenomenon” and to numerical simulation of the transient dynamics of rolling wheels with sliding effects. Such a model could become useful at the earlier stages of the engineering design instead of complex numerical models that are usually resource consuming.
The known models of the shimmy phenomenon are usually based on the nonholonomic condition of the steady rolling and consider as the main cause of instability only the tire deformation while the sliding and spinning are assumed to vanish, i. e. the dry friction effects are neglected. Another type of models consists in the ”rigid wheel” assumption, in other words only the dry friction effects are accounted on the background of the coupled dry friction theory whereas the deformed state effects are neglected. Such a theory is based on the complete accounting of the combined kinematics due to simultaneous sliding and spin and shows its efficiency for slightly deformed wheels and the unsteady rolling regimes. Our goal consists in the formulation of the combined model that takes into account as well as the deformed state as the dry friction effects. This model is based on the solution of some model problems for the tire using solid finite element simulation or various shell theories, the computing of a set of specific generalized rigidity factors for the tire model, and on the accounting for the shape of the contact spot and the contact pressure distribution after the numerical simulation of the tire-road contact interaction in quasi-statics. As a result, we obtain a model with only a few degrees of freedom but more general that the Keldysh’s or Klimov’s ones.
The use of mini-anchorage screws in the surgical orthodontic treatment of stage-III periodontitis: a clinical case
Authors: Alantar Alp , Andreani Jean François , Audi Grégoire , Tondelier Clémence , Pruvost Jean-Luc 
Published: October 2018

The use of miniscrews for orthodontic anchorage combined to periodontal treatment in aggressive periodontitis: case report and review of the literature. Introduction: Miniscrews (MSs) have gained rapid popularity among orthodontic specialists over the past decade. Subsequently, as general dental practitioners continue to provide general care for patients undergoing orthodontic treatment they are likely to encounter MSs. Observation: A 60-year-old woman concerned about generalized agressive periodontitis (generalized periodontitis stage-III) with complaints of diastema and spacing in the upper arch, received for ten years nonsurgical therapy via scaling and root planning combined with systemic antibiotics. Maxillary periodontal flaps achieved this primary periodontal treatment. As she complained of protrusion of her maxillary incisors she was referred for orthodontic treatment with palatinal MSs to retract and align the maxillary anterior segment. A 26 months follow-up showed esthetic and functional stability of the result. Discussion: This case report demonstrates efficacity of combined periodontal and orthodontic treatments using palatinal MSs in order to successfully contribute to treatment of stage-III periodontitis.
A method for the automated detection of solar radio bursts in dynamic spectra
Authors: Salmane Houssam , Weber Rodolphe , Abed-Meraim Karim , Klein Karl-Ludwig , Bonnin Xavier 
Published: October 2018

The variability of the solar corona, including flares and coronal mass ejections, affects the space environment of the Earth (heating and ionization of the atmosphere, magnetic field disturbances, and bombardment by high-energy particles). Electromagnetic emissions are the first signatures of a solar eruptive event which by modifying the electron density in the ionosphere may affect airborne technology and radio communications systems. In this paper, we present a new method to detect automatically radio bursts using data from the Nançay Decametre Array (NDA) in the band 10 MHz–80 MHz. This method starts with eliminating unwanted signals (Radio-Frequency Interference, RFI and Calibration signals) by analyzing the dynamic spectrum of the signal recorded in time. Then, a gradient median filter is applied to smooth and to reduce the variability of the signal. After denoising the signal, an automated solar radio burst detection system is applied. This system is based on a sequential procedure with adaptive constant-false-alarm rate (CFAR like detector) aimed to extract the spectra of major solar bursts. To this end, a semi-automatic software package is also developed to create a data base of all possible events (type II, III, IV or other) that could be detected and used for our performance assessment.
Clinical Assessment of Dysarthria in Children with Cerebellar Syndrome Associated with PMM2-CDG
Authors: Itzep Débora , Martínez-Monseny Antonio , Bolasell Mercè , Cuadras Daniel , Velázquez-Fragua Ramón , Gutierrez-Solana Luis , Macaya Alfons , Pérez-Dueñas Belén , Serrano Mercedes ,   CDG Spanish-Consortium
Published: October 2018

Phosphomannomutase deficiency (PMM2-CDG) causes a cerebellar syndrome that has been evaluated using the International Cooperative Ataxia Rating Scale (ICARS). However, no particular dysarthria tests have been used. Speech ICARS subscore subjectively assesses fluency and clarity of speech with two items. Repetition of syllables, traditionally used for characterization of ataxic speech, was validated in early-onset ataxia conditions. We assess the validity of the PATA test (SCA Functional Index [SCAFI]) in PMM2-CDG patients.PATA rates from 20 patients were compared with a control population were and correlated with ICARS and neuroimaging.There was a difference between the PATA rate in patients and controls. PATA rate increased with age in controls. In patients, the improvement of PATA rate with age was not significant. In patients, the PATA rate was negatively correlated with the total ICARS score and the Speech ICARS subscore. Regarding neuroimaging, midsaggital vermis relative diameter was positively correlated with PATA results. These last differences were also significant when the results are corrected by age.PATA rate provides an easy measure for a quantitative assessment of dysarthria that may help clinicians to monitor patients' evolution in a regular consultation. It could also be used in PMM2-CDG clinical trials implementing ICARS speech subscore information.
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1
Authors: Knecht Kirsten M. , Buzovetsky Olga , Schneider Constanze , Thomas Dominique , Srikanth Vishok , Kaderali Lars , Tofoleanu Florentina , Reiss Krystle , Ferreirós Nerea , Geisslinger Gerd , Batista Victor S. , Ji Xiaoyun , Cinatl Jindrich , Keppler Oliver T. , Xiong Yong 
Published: October 2018

Significance
Nucleoside analog drugs are widely used to treat a variety of cancers and viral infections. With an essential role in regulating the nucleotide pool in the cell by degrading cellular nucleotides, SAMHD1 has the potential to decrease the cellular concentration of frequently prescribed nucleoside analogs and thereby decrease their clinical efficacy in cancer therapy. To improve future nucleoside analog treatments, it is important to understand SAMHD1 interactions with these drugs. Our work thoroughly examines the extent to which nucleotide analogs interact with the catalytic and allosteric sites of SAMHD1. This work contributes to the assessment of SAMHD1 as a potential therapeutic target for cancer therapy and the future design of SAMHD1 modulators that might improve the efficacy of existing therapies.
The WISDOM Personalized Breast Cancer Screening Trial: Simulation Study to Assess Potential Bias and Analytic Approaches
Authors: Eklund Martin , Broglio Kristine , Yau Christina , Connor Jason T , Stover Fiscalini Allison , Esserman Laura J 
Published: October 2018

Abstract

Background
WISDOM (Women Informed to Screen Depending on Measures of Risk) is a randomized trial to assess whether personalized breast cancer screening—where women are screened biannually, annually, biennially, or not at all depending on risk and age—can prevent as many advanced (stage IIB or higher) cancers as annual screening in women ages 40–74 years across 5 years of trial time. The short study time in combination with design choices of not requiring study entry and exit mammograms for all participants may introduce different sources of bias in favor of either the personalized or the annual arm.

Methods
We designed a simulation model and performed 5000 virtual WISDOM trials to assess potential biases. Each virtual trial simulated 65 000 randomly assigned participants who were each assigned a risk stratum and a time to stage of at least IIB cancer sampled from an exponential distribution with the hazard rate based on the risk stratum. Results from the virtual trials were used to evaluate two candidate analysis strategies with respect to susceptibility for introducing bias: 1) difference between arms in total number of events over total trial time, and 2) difference in number of events within complete screening cycles.

Results
Based on the simulations, about 86 stage IIB or higher cancers will be detected within the trial and the total exposure time will be about 74 000 years in each arm. Potential ascertainment bias is introduced at study entry and exit. Analysis strategy 1 works better for the nonscreened stratum, whereas method 2 is considerably more unbiased for the strata of women screened biennially or every 6 months.

Conclusion
Combining the two candidate analysis approaches gives a reasonably unbiased analysis based on the simulations and is the method we will use for the primary analysis in WISDOM. Publishing the WISDOM analysis approach provides transparency and can aid the design and analysis of other individualized screening trials.
Invertebrate Genomics Provide Insights Into the Origin of Synaptic Transmission
Authors: Abrams Thomas W. , Sossin Wayne S. 
Published: October 2018

Abstract
During the evolution of synapses, existing molecules were exapted to serve in specific synaptic roles. Recent increased availability of assembled transcriptomes from organisms that evolved before and after the appearance of the earliest synapses provides the opportunity to trace molecular adaptations important for development of fast synaptic transmission. We discuss issues that affect transcriptome assembly and phylogenetic analysis, and which therefore impact this analysis. We use relatively recent transcriptomes of pre-bilaterians to examine the molecular evolution of three types of critical synapse-specific proteins: vesicular transporters, synaptotagmins and ionotropic glutamate receptors. The results emphasize the fundamental difficulties in defining the specific point at which a protein “assumes” a synaptic function. Nevertheless, the analysis informs our understanding of several major evolutionary topics, including the evolution of synaptic vesicles and the identity of the first neurotransmitter used for fast, synchronous transmission. This analysis is also relevant for the current discussion of whether neuronal and synaptic function evolved separately, once in ctenophores and once in cnidarians and the main bilaterian lineage.
Deconstruction and Timbre
Authors: Waltham-Smith Naomi 
Published: October 2018

Abstract
Why is philosophy captivated by sound and especially by its material existence as timbre? While Western metaphysics has long been fascinated by role of the voice in the construction of subjectivity, consciousness, and the human, deconstruction has turned with surprising frequency to the idea of sound-as-timbre as a way to think beyond paradigms of identity, self-presence, and the present. The article asks what motivates this preoccupation with timbre and what is at stake philosophically and politically in this move, focusing on the bell in Derrida’s Glas as a figure for timbre and for philosophy’s relation to its own outside. Derrida’s argument is contrasted with Jean-Luc Nancy’s notions of timbre and resonance and Agamben’s critique of grammatology.
TMEM16 Ca2+ Activated Cl– Channels and CLC Chloride Channels and Transporters
Authors: Boccaccio Anna , Pusch Michael 
Published: October 2018

Abstract
After the identification of TMEM16 proteins as the molecular counterparts of Ca2+-activated Cl– channels, their roles in shaping excitability in several parts of the central and peripheral nervous system are emerging. Their contribution might be excitatory, as in dorsal root ganglion neurons and olfactory sensory neurons, or at the contrary, contributing to hyperpolarization, as in thalamocortical neurons, being strictly related to the equilibrium potential for chloride that can differ among cells or cellular compartments. The ClC-2 channel, together with its auxiliary subunit GlialCAM, is most important in glia, and mutations in the CLCN2 and GLIALCAM genes lead to leukodystrophy. The endo/lysosomal chloride/proton antiporters ClC-3, ClC-4, ClC-6, and ClC-7/Ostm1 are involved in the homeostasis of endosomes and lysosomes, and ClC-3/ClC-4 may be involved in neurotransmitter loading of synaptic vesicles. Mutations in CLCN4 cause intellectual disability, and recessive mutations in CLCN7 or OSTM1 are associated with neurodegeneration.
Forces of Production and Relations of Production
Authors: Laibman David 
Published: October 2018

Abstract
Marx and Engels based the movement for socialism and communism on a scientific analysis of social evolution rather than on ahistorical moral longings. This, however, requires replacement of vague evocative formulations by rigorous theoretical foundations. Two recent proposals for grounding the theory of the forces and relations of production—“intentional primacy” and “competitive primacy”—provide elements for this project but fail to drive it home. A proposed third approach, “social‒functional primacy,” focuses on the correspondence between advancing human power over nature, on the one hand, and the changing requirements for reproducible systems of exploitation—incentive, coercion, and control—on the other. A core evolutionary ladder of modes of production is identified as the basis for reconstructing the immense complexity of actual history, thus overcoming the dichotomy between “hard” and “soft” approaches to historical materialist theory.