bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemberdayaan Ekonomi Umat Melalui Pengelolaan Dana Zakat Produktif
Authors: Sumarni Sumarni , Jumasrah Jumasrah , Rahayu Irma , Qalbi Nurul 
Published: December 2024

National Amil Zakat Agency (BAZNAS) is one of the government institutions that formally has the right and obligation to manage zakat funds in order to create effectiveness in zakat fund management services and can also increase the benefits of zakat for humanity in order to improve economic prosperity. BAZNAS Kolaka Regency with the qardhul hasan financing program cannot be said to be successful because of the problem of many mustahik who are delinquent and do not return the qardhul hasan funds caused by the absence of collateral on qardhul hasan financing. This type of research is descriptive, that is, with this method it is hoped that it can identify why and how a phenomenon occurs. The results of this research show that economic empowerment of the people through productive zakat fund management has been realized quite well, and namely the ZMart program (Zakat Mart), the utilization of productive zakat funds can be said to be successful in increasing economic empowerment.
Analisis Kinerja Reksa Dana Saham Syariah di Indonesia
Authors: Ningrum Retno Widya , Musadat Irfan Achmad , Pramayuda Agung 
Published: December 2024

During the Covid-19 pandemic, the JCI produced higher returns compared to the Sharia Stock Mutual Fund Index with quite a large difference in figures. IHSG produced a return of 51.83% while the Sharia Stock Mutual Fund Index only produced a return of 12.85%. This research aims to provide an overview of the mutual fund performance assessment process and analysis of this assessment. There are several methods for assessing investments in portfolio form, including Sharpe Ratio, Treynor Ratio, Jensen's Alpha and Information Ratio. The results showed that in March - December 2020, it was discovered that Panin Dana Syariah Saham received the highest performance score using two methods, namely the Sharpe ratio and Treynor ratio. In 2021, Panin Dana Syariah Saham received the highest performance score using three methods, namely Sharpe ratio, Jensen's alpha and Information ratio. In 2022, HPAM Ekuitas Syariah Berkah received the highest performance score using three methods, namely Sharpe ratio, Jensen's alpha and Information ratio. In January – June 2023, the Batavia Dana Saham Syariah received the highest performance score using two methods, namely the Sharpe ratio and the Information ratio. However, if you look at the mutual fund that received the highest performance scores during the Covid-19 pandemic, it was Panin Dana Syariah Saham.
Cryptosporidium parvum infection alters the intestinal mucosa transcriptome in neonatal calves: impacts on epithelial barriers and transcellular transport systems
Authors: Veshkini Arash , Kühn Christa , Dengler Franziska , Bachmann Lisa , Liermann Wendy , Helm Christiane , Ulrich Reiner , Delling Cora , Hammon Harald M. 
Published: December 2024

IntroductionCryptosporidium parvum (C. parvum) is the most prevalent enteric protozoan parasite causing infectious diarrhea in neonatal calves worldwide with a direct negative impact on their health and welfare. This study utilized next-generation sequencing (NGS) to deepen our understanding of intestinal epithelial barriers and transport mechanisms in the pathophysiology of infectious diarrhea in neonatal calves, which could potentially unveil novel solutions for treatment.MethodsAt day 1 of life, male Holstein-Friesian calves were either orally infected (n = 5) or not (control group, n = 5) with C. parvum oocysts (in-house strain LE-01-Cp-15). On day 8 after infection, calves were slaughtered and jejunum mucosa samples were taken. The RNA was extracted from collected samples and subjected to sequencing. Differentially expressed genes (DEG) between the infected and CTRL groups were assessed using DESeq2 at a false discovery rate &lt; 0.05 and used for gene ontology (GO) and pathway enrichment analysis in Cytoscape (v3.9.1).Results and discussionTo study the pathophysiology of infectious diarrhea on intestinal permeability, 459 genes related to epithelial cell barrier integrity and paracellular and transmembrane transport systems were selected from 12,908 identified genes in mucus. Among, there were 61 increased and 109 decreased gene transcripts belonged to adhesion molecules (e.g. ADGRD1 and VCAM1), ATP-binding cassette (ABC, e.g. ABCC2 and ABCD1) and solute carrier (SLC, e.g. SLC28A2 and SLC38A3) transporters, and ion channels (e.g. KCNJ15). Our results suggest deregulation of cellular junctions and thus a possibly increased intestinal permeability, whereas deregulation of ABC and SLC transporters and ion channels may influence the absorption/secretion of amino acids, carbohydrates, fats, and organic compounds, as well as acid-based balance and osmotic hemostasis. Besides pathogen-induced gene expression alterations, part of the DEG may have been triggered or consequently affected by inflammatory mechanisms. The study provided a deeper understanding of the pathophysiology of infectious diarrhea in neonatal calves and the host-pathogen interactions at the transcript level. For further studies with a particular focus on the transport system, these results could lead to a new approach to elucidating pathophysiological regulatory mechanisms.
Analysis of risk factors faced by Chinese international students based on fuzzy comprehensive evaluation model
Authors: Gao Junhong , Zhao Zhiyu , Li Hongwei 
Published: December 2024

IntroductionChina has contributed the most international students to the global higher-education sector for over a decade. Existing research has indicated various risk factors faced by international students. However, few studies have examined the risks experienced by Chinese international students. Two research questions were investigated in this study: (1) Which risk factor has the greatest impact on Chinese international students when studying abroad? and (2) Which risk factor is most frequently experienced by Chinese international students when studying abroad?MethodTo address these questions, this study proposes a fuzzy comprehensive evaluation model for evaluating the risk factors faced by Chinese international students. The model comprises six second-level factors and 22 third-level indicators, which was empirically examined by data collected through 556 questionnaires. The analytical hierarchy process and factor analysis were employed to calculate the index weight of second-level factors and third-level indicators.ResultsThe results reveal that the risk factor, psychological discrepancy, has the greatest impact and is most likely to be experienced by Chinese international students. The paper provides an integrated research perspective to study the risk of international students.DiscussionThe paper discussed the factors that impact the risk faced by Chinese international students. The risk faced by Chinese international students was found to be high. Psychological discrepancy, academic choice, and cross-cultural adaptation were the three risk factors that were most likely to be experienced by Chinese international students. Psychological discrepancy, barriers to study, and unforeseen incidents had the highest impact on total risk. Therefore, attention should be paid to these risk factors to avoid the occurrence of risk and its negative impacts.
Serum IL-23 levels reflect a myeloid inflammatory signature and predict the response to apremilast in patients with psoriatic arthritis
Authors: De Santis Maria , Tonutti Antonio , Isailovic Natasa , Motta Francesca , Rivara Radu Marian , Ragusa Rita , Guidelli Giacomo M. , Caprioli Marta , Ceribelli Angela , Renna Daniela , Luciano Nicoletta , Selmi Carlo 
Published: December 2024

BackgroundThe phosphodiesterase 4 (PDE4) inhibitor apremilast downregulates the production of IL-23 and other pro-inflammatory cytokines involved in the pathogenesis of psoriatic arthritis (PsA).AimTo investigate the effects of apremilast on the production of cytokines by peripheral blood monocyte-derived macrophages, innate-like lymphocyte cells (ILCs), mucosal-associated invariant T (MAIT) cells, γδ T cells, natural killer (NK) cells, and NKT-like cells from patients with PsA manifesting different clinical responses to the treatment.MethodsPeripheral blood samples were obtained from patients with PsA at baseline and after 1 and 4 months of apremilast therapy (n = 23) and 20 controls with osteoarthritis. Cytokine expression in peripheral blood monocyte-derived macrophages and ILCs/MAIT/γδT/NK/NKT-like cells was tested by RT-PCR and FACS analyses, respectively; cytokine levels in culture supernatants and sera were analyzed by ELISA.ResultsPsA monocyte-derived macrophages exhibited higher expressions of IL-23, IL-1β, and TNF-α, compared with OA controls, more profoundly in patients responding to apremilast. There were 17/23 (74%) PsA patients who were classified as responders to apremilast at 4 months, and a baseline serum IL-23 &gt;1.4 pg/mL was associated with the responder status (AUCROC 0.79; sensitivity 100%, specificity 68%). Of note, apremilast led to a significantly reduced expression of IL-23 in peripheral blood monocyte-derived macrophages; IL-17 in ILC1 and in T cells of responder patients; IFN-γ in γδ T lymphocytes.ConclusionAn enhanced myeloid inflammatory signature characterizes PsA monocyte-derived macrophages, and serum IL-23 levels represent candidate biomarkers for PsA response to apremilast.
Developing a digital phenotype to subdivide adult immunosuppressed COVID-19 outcomes within the English Primary Care Sentinel Network
Authors: Leston Meredith , Kar Debasish , Forbes Anna , Jamie Gavin , Wimalaratna Rashmi , Jiwani Gunjan , Ordóñez-Mena José M. , Stewart Daniel E. , Whitaker Heather , Joy Mark , Lee Lennard Y. W. , Hobbs F. D. Richard , de Lusignan Simon 
Published: December 2024

BackgroundAdults classified as immunosuppressed have been disproportionately affected by the COVID-19 pandemic. Compared to the immunocompetent, certain patients are at increased risk of suboptimal vaccine response and adverse health outcomes if infected. However, there has been insufficient work to pinpoint where these risks concentrate within the immunosuppressed spectrum; surveillance efforts typically treat the immunosuppressed as a single entity, leading to wide confidence intervals. A clinically meaningful and computerised medical record (CMR) compatible method to subdivide immunosuppressed COVID-19 data is urgently needed.MethodsWe conducted a rapid scoping review into COVID-19 mortality across UK immunosuppressed categories to assess if differential mortality risk was a viable means of subdivision. We converted the risk hierarchy that surfaced into a pilot digital phenotype—a valueset and series of ontological rules ready to extract immunosuppressed patients from CMR data and stratify outcomes of interest in COVID-19 surveillance dataflows.ResultsThe rapid scoping review returned COVID-19 mortality data for all immunosuppressed subgroups assessed and revealed significant heterogeneity across the spectrum. There was a clear distinction between heightened COVID-19 mortality in haematological malignancy and transplant patients and mortality that approached the immunocompetent baseline amongst cancer therapy recipients, autoimmune patients, and those with HIV. This process, complemented by expert clinical input, informed the curation of the five-part digital phenotype now ready for testing in real-world data; its ontological rules will enable mutually exclusive, hierarchical extraction with nuanced time and treatment conditions. Unique categorisations have been introduced, including ‘Bone Marrow Compromised’ and those dedicated to differentiating prescriptions related and unrelated to cancer. Codification was supported by existing reference sets of medical codes; absent or redundant codes had to be resolved manually.DiscussionAlthough this work is in its earliest phases, the development process we report has been highly informative. Systematic review, clinical consensus building, and implementation studies will test the validity of our results and address criticisms of the rapid scoping exercise they are predicated on.ConclusionComprehensive testing for COVID-19 has differentiated mortality risks across the immunosuppressed spectrum. This risk hierarchy has been codified into a digital phenotype for differentiated COVID-19 surveillance; this marks a step towards the needs-based management of these patients that is urgently required.
Differences in cerebral structure among patients with amnestic mild cognitive impairment and patients with Alzheimer’s disease
Authors: Cui Xiaorui , Li Mingpeng , Lei Guanxiong , Wang Jie , Pan Jialin , Zhu Sheng , Wu Tao , Zou Liangyu , Yan Jianhui 
Published: December 2024

BackgroundBrain has been shown to undergo progressive atrophy in patients with Alzheimer’s disease (AD); however, more evidence is needed to elucidate how the brain structure changes during the progression to AD. Here, we observed differences in the cerebral structure among patients with amnestic mild cognitive impairment (aMCI) and patients with AD.MethodsA total of 46 participants were selected and divided into AD, aMCI, and healthy control (HC) groups. Structural magnetic resonance imaging (sMRI) was performed on all participants. Voxel-based morphometry (VBM) and surface-based morphometry (SBM) techniques were utilized to analyze sMRI data so as to identify significant differences among the specific brain regions of these three groups. Then, a correlation analysis was performed on the characteristics of the identified brain regions and the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) cognitive assessment scores.ResultsThe volume of the left precuneus region, which was identified by voxel-based morphometry, and the thickness of both sides of the inferior parietal, which was identified by surface-based morphometry, were shown to be less in AD/aMCI patients, compared to those of the HC. The correlation analysis showed that there were significant differences between the volume of the left precuneus region and the MMSE/MoCA scores, as well as between the thickness of the left and right sides of the inferior parietal region and the MMSE/MoCA scores.ConclusionThe sMRI characteristics of the identified brain regions were considered to be potential predictive diagnostic biomarkers for AD.Systematic review registrationIdentifier: ChiCTR2400092593.
Academic and Community Hospitals differ in stroke subtype classification and cardiac monitoring: the DiVERT multi-center cohort study
Authors: Rose David Z. , Shah Ruchir A. , Snavely Josh , Hairston Marla , Adams Stephen , Ziegler Paul D. , Rosemas Sarah C. , Chandler Michael , Carta Roberto , Neisen Karah B. , Franco Noreli C. , Devlin Thomas G. 
Published: December 2024

BackgroundCardiac monitoring strategies to detect occult atrial fibrillation (AF) post-stroke differ among healthcare institutions. This may be related to discrepancies in stroke subtype classification/adjudication, and/or consultation of cardiology specialists at Community Hospitals (CoH) and Academic Centers (AcC). Identifying the degree of heterogeneity may encourage development of guideline-directed monitoring protocols, result in higher AF detection rates and treatments, and fewer strokes.MethodsThe DiVERT (SeconDary Stroke PreVEntion ThRough Pathway ManagemenT) study was designed to characterize post-stroke cardiac monitoring practices in a hospital setting. Care pathways were assessed with in-person stakeholder interviews; patient-level data were reviewed using electronic medical records.ResultsDiVERT identified 2,475 patients with diagnoses of cryptogenic (83.6% vs. 33.1%, p &lt; 0.001), large vessel disease (LVD) (13.3% vs. 37.0%, p &lt; 0.001), or small vessel disease (SVD) (3.1% vs. 29.9%, p &lt; 0.001) stroke, at CoH and AcC, respectively. CoH consulted cardiology significantly less than AcC (12.3% vs. 34.7%, p &lt; 0.001) and ordered significantly fewer short- or long-term cardiac monitors than AcC (6.8% vs. 69.2%, p &lt; 0.001). CoH had shorter length of stay (5.3 vs. 9.4 days, p &lt; 0.001) and patient demographics were significantly different (p &lt; 0.001 for age, ethnicity and race).ConclusionSignificant heterogeneity in cardiac monitoring post-stroke exists: CoH reported 2.5-times more cryptogenic stroke than AcC yet ordered 10-times fewer short/long-term cardiac monitors to look for AF. Significant differences in patient demographics among institutions may account for this discrepancy. Regardless, efforts to reduce heterogeneity are warranted to improve AF detection and treatment and prevent recurrent stroke.
Higher oxidative balance score is associated with lower female infertility: a cross-sectional study
Authors: Lei Xiong , Liu Xiling , Yu Chunchun , Xia Lijing , Zhou Liwen , Yao Can , Xu Zhixiao 
Published: December 2024

BackgroundAn imbalance of the pro-oxidant and antioxidant profiles in the body contributes to the development of diseases, including female infertility.MethodsIn this study, we performed a secondary analysis of the National Health and Nutrition Examination Survey and calculated the values of oxidative balance score (OBS). A weighted logistic regression model was used to explore the potential relationship between OBS (continuous factor and quartile set) and female infertility, and the P for trend was calculated. Subgroup analyses were also carried out further to explore the association between OBS and female infertility, and the P for interactions were obtained.ResultsThere were 1,626 females (aged 18 to 45) included in the study, including 198 with infertility and a prevalence of approximately 13.28%. Multifactorial logistic regression showed a 5% decrease in infertility for each unit increased in OBS (OR, 0.95; 95% CI, 0.92 to 0.98). When OBS was used as a categorical variable, female infertility decreased by 60% in the highest OBS group compared with the lowest OBS group (OR, 0.40; 95% CI, 0.21 to 0.74). In addition, subgroup analyses showed that the negative association between OBS and infertility was significant in the non-chronic disease (hypertension and diabetes) population, those with less than a high school educational background, poverty-to-income ratio (1 to 3), and those with more than 30 years of age.ConclusionHigher OBS was negatively associated with female infertility. Further prospective studies are needed to determine causality and to provide new perspectives on female infertility in the context of diet and lifestyle.
miR-198 targets TOPORS: implications for oral squamous cell carcinoma pathogenesis
Authors: Kaushik Pankhuri , Mishra Radha , Gopal Champaka , Kumar Arun 
Published: December 2024

BackgroundmiRNAs play a critical role in the progression of various diseases, including oral squamous cell carcinoma (OSCC), which represents a major health concern and is one of the leading causes for new cancer cases worldwide. The miRNA dysregulation causes havoc and could be attributed to various factors, with epigenetic silencing of tumor suppressor genes being a major contributor to tumorigenesis. In this study, we have explored the tumor suppressive role of miR-198 in OSCC.MethodsThe tumor suppressive effect of miR-198 is established using miRNA analysis in OSCC cell lines, patient samples and xenograft nude mice model. The relationship between the miR-198 and TOPORS is explored using bioinformatics analyses, qRT-PCR, dual-luciferase reporter assay, Western blotting and cancer hall marks assays. The hypermethylation of the MIR198 promoter is confirmed using bisulfite sequencing PCR.ResultsWe have found miR-198 to be upregulated in OSCC cells treated with 5-Azacytidine, a known DNA methyltransferase inhibitor. Upregulation of miR-198 in 5-Azacytidine treated OSCC cells appears to be due to methylation of the MIR198 promoter. Using bioinformatics analysis and dual-luciferase reporter assay, we have identified TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase) as a novel gene target for miR-198. miR-198-mediated repression of TOPORS decreases cell proliferation and anchorage-independent growth and enhances apoptosis of OSCC cells, which is dependent on the presence of the 3′UTR in TOPORS. An inverse correlation between the expression levels of miR-198 and TOPORS is observed in OSCC patient samples, highlighting the biological relevance of their interaction. Delivery of a synthetic miR-198 mimic to OSCC cells results in a significant decrease in xenograft size in nude mice, potentiating its use in therapeutics.ConclusionsThese results suggest that miR-198 is epigenetically silenced in OSCC, which promotes tumor growth, in part, by upregulating the levels of TOPORS.
Nanomedicine based on chemotherapy-induced immunogenic death combined with immunotherapy to enhance antitumor immunity
Authors: Chen Yichang , Mao Kuirong , Han Dongxiao , Ma Ruolin , Sun Tianmeng , Zhang Haipeng , Han Bing 
Published: December 2024

IntroductionChemo-immunotherapy based on inducing tumor immunogenic cell death (ICD)with chemotherapy drugs has filled the gaps between traditional chemotherapy and immunotherapy. It is verified that paclitaxel (PTX) can induce breast tumor ICD. From this basis, a kind of nanoparticle that can efficiently deliver different drug components simultaneously is constructed. The purpose of this study is for the sake of exploring the scheme of chemotherapy-induced ICD combined with other immunotherapy to enhance tumor immunogenicity and inhibit the growth, metastasis, and recurrence of breast tumors, so as to provide a research basis for solving the tough problem of breast cancer treatment.MethodsNanomedicine loaded with PTX, small interference RNA that suppresses CD47 expression (CD47siRNA, siCD47), and immunomodulator R848 were prepared by the double emulsification method. The hydrodynamic diameter and zeta potential of NP/PTX/siCD47/R848 were characterized. Established the tumor-bearing mice model of mouse breast cancer cell line (4T1) in situ and observed the effect of intravenous injection of NP/PTX/siCD47/R848 on the growth of 4T1 tumor in situ. Flow cytometry was used to detect the effect of drugs on tumor immune cells.ResultsNP/PTX/siCD47/R848 nano-drug with tumor therapeutic potential were successfully prepared by double emulsification method, with particle size of 121.5 ± 4.5 nm and surface potential of 36.1 ± 2.5 mV. The calreticulin on the surface of cell membrane and extracellular ATP or HMGB1 of 4T1 cells increased through treatment with NPs. NP/PTX-treated tumor cells could cause activation of BMDCs and BMDMs. After intravenous injection, NP/PTX could quickly reach the tumor site and accumulate for 24 h. The weight and volume of tumor in situ in the breast cancer model mice injected with nanomedicine through the tail vein were significantly lower than those in the PBS group. The ratio of CD8+/CD4+ T cells in the tumor microenvironment and the percentage of dendritic cells in peripheral blood increased significantly in breast cancer model mice injected with nano-drugs through the tail vein.DiscussionBriefly, the chemotherapeutic drug paclitaxel can induce breast cancer to induce ICD. The nanomedicine which can deliver PTX, CD47siRNA, and R848 at the same time was prepared by double emulsification. NP/PTX/siCD47/R848 nano-drug can be enriched in the tumor site. The experiment of 4T1 cell tumor-bearing mice shows that the nano-drug can enhance tumor immunogenicity and inhibit breast tumor growth, which provides a new scheme for breast cancer treatment. (Graphical abstract)