bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Powered Tactile Sensor Array Systems Based on the Triboelectric Effect
Authors: Tao Juan , Bao Rongrong , Wang Xiandi , Peng Yiyao , Li Jing , Fu Sheng , Pan Caofeng , Wang Zhong Lin 
Published: December 2018

AbstractWith the arrival of intelligent terminals, tactile sensors which are capable of sensing various external physical stimuli are considered among the most vital devices for the next generation of smart electronics. To create a self‐powered tactile sensor system that can function sustainably and continuously without an external power source is of crucial significance. An overview of the development in self‐powered tactile sensor array system based on the triboelectric effect is systematically presented. The combination of multi‐functionalization and high performance of tactile sensors aimed at achieving highly comprehensive performance is presented. For the tactile sensor unit, a development is summarized based on the two primary modes which are vertical contact–separation and single‐electrode. For the pressure mapping array, the resolution is significantly enhanced by the novel cross‐type configuration based on the single‐electrode mode. Integrated with other mechanisms, the performance will be further elevated by broadening of the detect range and realizing of visualization of pressure imaging. Then, two main applications of human–machine interaction (HMI) and trajectory monitoring are comprehensively summarized. Finally, the future perspectives of self‐powered tactile sensor system based on triboelectric effect are discussed.
Magnesium Anodes with Extended Cycling Stability for Lithium‐Ion Batteries
Authors: Zhang Zailei , Zhao Man , Xia Mengyang , Qi Ruijie , Liu Mingyang , Nie Jinhui , Wang Zhong Lin , Lu Xianmao 
Published: December 2018

AbstractMagnesium as a promising alloy‐type anode material for lithium‐ion batteries features both high theoretical specific capacity (2150 mAh g−1) and stack energy density (1032 Wh L−1). However, the poor cycling performance of Mg‐based anodes severely limits their application, mainly because high‐impedance films can grow easily on the surface of Mg and cause diminished electrochemical activity. As a result, the capacities of reported Mg anodes fade quickly in less than 100 cycles. To improve the stability of Mg anodes, 3D Cu@Mg@C structures are prepared by depositing Mg/C composite on 3D Cu current collectors. The resulting 3D Cu@Mg@C anodes can deliver an initial capacity of 1392 mAh g−1. With a second‐cycle capacity of 1255 mAh g−1, 91% can be retained after 1000 cycles at 0.5 C. When cycled at 2 C, the initial capacity can be maintained for 4000 cycles. This remarkably improved cycling performance can be attributed to both the 3D structure and the embedded carbon layers of the 3D Cu@Mg@C electrodes that facilitate electrical contact and prevent the growth of high‐impedance films during cycling. With 3D Cu@Mg@C anodes and LiFePO4 cathodes, full cells are assembled and charging by a rotating triboelectric nanogenerator that can harvest mechanical energy is demonstrated.
Microneedle‐Array Patch Fabricated with Enzyme‐Free Polymeric Components Capable of On‐Demand Insulin Delivery
Authors: Chen Siyuan , Matsumoto Hiroko , Moro‐oka Yuki , Tanaka Miyako , Miyahara Yuji , Suganami Takayoshi , Matsumoto Akira 
Published: December 2018

AbstractAchieving persistent glycemic control in a painless and convenient way is the ultimate goal of diabetes management. Herein, an “enzyme‐free” polymeric microneedle (MN)‐array patch composed of a boronate‐containing hydrogel semi‐interpenetrated by biocompatible silk fibroin is developed. Consistent with the previous reports, the presence of the boronate‐hydrogel allows for glucose‐responsive diffusion‐control of insulin, while the crystalline fibroin component serves as a matrix‐stiffener to validate skin penetration. Remarkably, this “enzyme‐free” smart artificial on‐skin pancreas prototype remains stable for at least 2 months in an aqueous environment. Furthermore, it establishes sustained as well as acute glucose‐responsive insulin delivery, and is to the authors' knowledge, the first successful material design addressing such two technical challenges at once on an MN format. This long‐acting, on‐demand insulin delivery technology may offer a candidate for a next‐generation diabetes therapy that is remarkably stable, safe, economically efficient, and capable of providing both acute‐ and continuous glycemic control in a manner minimally dependent on patient compliance.
A Self‐Pumping Dressing for Draining Excessive Biofluid around Wounds
Authors: Shi Lianxin , Liu Xi , Wang Wenshuo , Jiang Lei , Wang Shutao 
Published: December 2018

AbstractExcessive biofluid around wounds often causes infection and hinders wound healing. However, the intrinsic hydrophilicity of the conventional dressing inevitably retains excessive biofluid at the interface between the dressing and the wound. Herein, a self‐pumping dressing is reported, by electrospinning a hydrophobic nanofiber array onto a hydrophilic microfiber network, which can unidirectionally drain excessive biofluid away from wounds and finally accelerate the wound healing process. The hydrophilic microfiber network offers a draining force to pump excessive biofluid through the hydrophobic nanofiber array, which can further keep those pumped biofluids from rewetting the wounds. In the proof of concept, the self‐pumping dressing unidirectionally drains the biofluid from murine dorsum wounds, thereby resulting in faster wound healing than conventional dressings. This unique self‐pumping dressing has enormous potential to be a next‐generation dressing for healing wounds clinically.
Nanocatalysts‐Augmented and Photothermal‐Enhanced Tumor‐Specific Sequential Nanocatalytic Therapy in Both NIR‐I and NIR‐II Biowindows
Authors: Feng Wei , Han Xiuguo , Wang Rongyan , Gao Xiang , Hu Ping , Yue Wenwen , Chen Yu , Shi Jianlin 
Published: December 2018

AbstractThe tumor microenvironment (TME) has been increasingly recognized as a crucial contributor to tumorigenesis. Based on the unique TME for achieving tumor‐specific therapy, here a novel concept of photothermal‐enhanced sequential nanocatalytic therapy in both NIR‐I and NIR‐II biowindows is proposed, which innovatively changes the condition of nanocatalytic Fenton reaction for production of highly efficient hydroxyl radicals (•OH) and consequently suppressing the tumor growth. Evidence suggests that glucose plays a vital role in powering cancer progression. Encouraged by the oxidation of glucose to gluconic acid and H2O2 by glucose oxidase (GOD), an Fe3O4/GOD‐functionalized polypyrrole (PPy)‐based composite nanocatalyst is constructed to achieve diagnostic imaging‐guided, photothermal‐enhanced, and TME‐specific sequential nanocatalytic tumor therapy. The consumption of intratumoral glucose by GOD leads to the in situ elevation of the H2O2 level, and the integrated Fe3O4 component then catalyzes H2O2 into highly toxic •OH to efficiently induce cancer‐cell death. Importantly, the high photothermal‐conversion efficiency (66.4% in NIR‐II biowindow) of the PPy component elevates the local tumor temperature in both NIR‐I and NIR‐II biowindows to substaintially accelerate and improve the nanocatalytic disproportionation degree of H2O2 for enhancing the nanocatalytic‐therapeutic efficacy, which successfully achieves a remarkable synergistic anticancer outcome with minimal side effects.
Transforming Weakness into Strength: Photothermal‐Therapy‐Induced Inflammation Enhanced Cytopharmaceutical Chemotherapy as a Combination Anticancer Treatment
Authors: Zhang Lei , Zhang Ying , Xue Yanan , Wu Yue , Wang Qianqian , Xue Lingjing , Su Zhigui , Zhang Can 
Published: December 2018

AbstractA new synergistic treatment that combines photothermal therapy (PTT) and inflammation‐mediated active targeting (IMAT) chemotherapy based on cytopharmaceuticals is developed. During PTT, the photothermal tumor ablation is accompanied by an inflammatory effect and upregulation of inflammatory factors at the tumor site, which may accelerate tumor regeneration. Moreover, PTT‐induced inflammation can also recruit neutrophils (NEs) to the tumor site. To convert the disadvantages of PTT‐induced inflammation into strengths, NEs are investigated as cytopharmaceuticals for IMAT chemotherapy to further inhibit the tumor recurrence after PTT due to the chemotaxis of NEs to the inflammatory sites. In this study, PEGylated gold nanorods (PEG‐GNRs) are explored as the photothermal agent and paclitaxel‐loaded cytopharmaceuticals of NEs as the IMAT chemotherapeutic agent. PTT is conducted at 72 h postinjection of PEG‐GNRs, followed by cytopharmaceuticals for IMAT chemotherapy. It is demonstrated that the cytopharmaceuticals effectively accumulate in the tumor sites after PTT, which leads to a significant enhancement of antitumor efficacy and a reduction in systemic toxicity. These studies suggest that PTT‐induced inflammation further enhances the chemotherapy of cytopharmaceuticals, and the combination of PTT and IMAT chemotherapy may be a promising synergistic strategy for targeted cancer therapy.
Photoelectrochemically Active N‐Adsorbing Ultrathin TiO2 Layers for Water‐Splitting Applications Prepared by Pyrolysis of Oleic Acid on Iron Oxide Nanoparticle Surfaces under Nitrogen Environment
Authors: Kertmen Ahmet , Barbé Enzo , Szkoda Mariusz , Siuzdak Katarzyna , Babačić Višnja , Torruella Pau , Iatsunskyi Igor , Kotkowiak Michał , Rytel Karol , Estradé Sònia , Peiró Francesca , Jurga Stefan , Li Yanguang , Coy Emerson 
Published: December 2018

AbstractHighly performing photocatalytic surfaces are nowadays highly desirable in energy fields, mainly due to their applicability as photo water‐splitting electrodes. One of the current challenges in this field is the production of highly controllable and efficient photoactive surfaces on many substrates. Atomic layer deposition has allowed the deposition of photoactive TiO2 layers over wide range of materials and surfaces. However, nitrogen doping of the growing layers, a highly effective way of controlling the absorption edges of photoactive surfaced, is still a challenging task. Here, the preparation of hierarchical nanostructured surfaces based on Langmuir–Schaefer and atomic layer deposition is proposed. Ultrathin TiO2 layers that are photoelectrochemically active in water splitting are prepared by a relatively low‐temperature catalytic decomposition of oleic acid capping layers of iron oxide nanoparticles and the posterior nitrogen adsorption. The results evidence that simple N‐adsorption is sufficient to narrow the bandgap of TiO2 layers that is equal to bandgap narrowing (0.12 eV) observed for substitutionally N‐doped materials. The photocatalytic activity tests of the prepared surfaces in water‐splitting applications demonstrate ≈90% increase in the activity of the N‐adsorbing TiO2 layers.
Facile and Efficient Welding of Silver Nanowires Based on UVA‐Induced Nanoscale Photothermal Process for Roll‐to‐Roll Manufacturing of High‐Performance Transparent Conducting Films
Authors: Liang Xianwen , Lu Jibao , Zhao Tao , Yu Xuecheng , Jiang Qingshan , Hu Yougen , Zhu Pengli , Sun Rong , Wong Ching‐Ping 
Published: December 2018

AbstractThe continuous, large‐area solution‐processed production of silver nanowire (AgNW) transparent conducting films with outstanding optoelectronic and mechanical performance remains a challenge. Here, efficient welding of AgNWs is demonstrated using ultraviolet A (UVA) with the specific wavelength range from ≈320 to ≈400 nm based on a nanoscale photothermal process. The AgNW welding shows a self‐terminating and self‐limiting nature, and sensitivity to diameter of AgNWs. Sheet resistance of the UVA‐illuminated (UVAI) AgNW films rapidly drops within 2 min without loss of transmittance. For the UVAI AgNW (30 nm in diameter) film, decrement of sheet resistance approaches three orders of magnitude (≈105–102 Ohm sq−1) with original transmittance being (97%) retained, which significantly enhances its optoelectronic properties. Enhanced mechanical flexibility, electromagnetic interference (EMI) shielding effectiveness (SE), and heating performance are obtained in the UVAI AgNW films. The SE and plateau temperature of the AgNW film increase to 25 dB and 50 °C after illumination, respectively. Smart window, transparent heater, and triboelectric nanogenerator based on the UVAI AgNW film demonstrate its versatile applications in optoelectronics. Finally, the welding method is easily integrated into a roll‐to‐roll process to manufacture AgNW film with a low sheet resistance of 25 Ohm sq−1 and a high transmittance of 90%, and excellent flexibility.
Compact Aberration‐Corrected Spectrometers in the Visible Using Dispersion‐Tailored Metasurfaces
Authors: Zhu Alexander Y. , Chen Wei Ting , Sisler Jared , Yousef Kerolos M. A. , Lee Eric , Huang Yao‐Wei , Qiu Cheng‐Wei , Capasso Federico 
Published: December 2018

AbstractThe spectral resolution and range of conventional spectrometers are typically limited by optical aberrations of their focusing elements, mainly due to chromatically induced astigmatism and an intrinsically curved focal plane. Traditional approaches to overcome this challenge require additional optical components which introduce significant bulk and design complexity to the system and prevent easy integration with portable devices. Here a single planar off‐axis focusing metalens consisting of subwavelength TiO2 nanofins whose focal spots lie along a plane and undergo minimal focal spot broadening for almost 200 nm across the visible spectrum is demonstrated. This allows us to achieve a miniature aberration‐corrected spectrometer with nanometer spectral resolution, while having a beam propagation distance of only 4 cm to the camera plane. This is achieved by dispersion engineering: tailoring the phase, group delay (GD) and GD dispersion of the metalens. This approach is general and can also be used to introduce customized functionalities to the metalens such as a linear dispersion in the frequency domain with minimal additional overhead.
Silver‐Catalyzed Carbocyclization of Azide‐Tethered Alkynes: Expeditious Synthesis of Polysubstituted Quinolines
Authors: Su Han , Bao Ming , Huang Jingjing , Qiu Lihua , Xu Xinfang 
Published: December 2018

AbstractA silver‐catalyzed carbocyclization of azide‐tethered alkynes has been developed for the synthesis of polysubstituted quinolines in good to high yields. Mechanistic studies indicate that this reaction is initiated by a silver‐catalyzed 6‐endo‐dig azide‐yne cyclization, followed by a formal R−X (X=Cl, Br, or I) insertion with external halide through a ylide intermediate. The salient features of this reaction include readily available materials, inexpensive silver‐catalyst, mild reaction conditions, good functional group tolerance, and ease in further transformations.magnified image
Direct Carbamoylation of Quinoline N‐oxides with Hydrazinecarboxamides via C−H Bond Activation Catalyzed by Copper Catalyst
Authors: Li Guang‐Hui , Dong Dao‐Qing , Yang Yun , Yu Xian‐Yong , Wang Zu‐Li 
Published: December 2018

AbstractAn efficient method for the carbamoylation of quinoline N‐oxides catalyzed by copper was developed. A variety of quinoline N‐oxides and hydrazinecarboxamides with different groups was well tolerated in this system.magnified image
Revealing Activity Trends of Metal Diborides Toward pH‐Universal Hydrogen Evolution Electrocatalysts with Pt‐Like Activity
Authors: Li Qiuju , Zou Xu , Ai Xuan , Chen Hui , Sun Lei , Zou Xiaoxin 
Published: December 2018

AbstractUnderstanding of catalytic trends is an important prerequisite for providing rational guidance toward the prediction of advanced catalysts as well as the development of original materials design principles. A combined theoretical and experimental study that reveals the periodic trends in electrocatalytic activity for the hydrogen evolution reaction (HER) from Group IV B to Group VIII metal diborides is reported here. Theoretical results demonstrate a general linear relationship between the catalytic activity and d‐band center of metal diboride, meaning that the latter can serve as a descriptor of activity. And theoretical results also predict ruthenium diboride as the most competitive, nonplatinum candidate among metal diborides for HER because this material has a suitable d‐band center and a high density of efficient active sites. Furthermore, the experimental results validate the theoretical activity trends and identify ruthenium diboride as an efficient, pH‐universal electrocatalyst with Pt‐like activity for HER under both acidic and alkaline media.
Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school‐aged children with obesity/overweight and with normal weight
Authors: González‐Herrera Lizbeth , Zavala‐Castro Jorge , Ayala‐Cáceres Claudia , Pérez‐Mendoza Gerardo , López‐González María José , Pinto‐Escalante Doris , Canto‐Cetina Thelma , García‐Escalante María Guadalupe , Rubi‐Castellanos Rodrigo , Contreras‐Capetillo Silvina , Herrera‐Sanchez Fernando , Méndez‐Domínguez Nina , Alcocer‐Gamboa Alberto 
Published: December 2018

AbstractObjectivesGenetic variation of the fat mass and obesity associated gene (FTO) has been identified as a risk factor for obesity and obesity traits. Distribution of FTO single nutleotide polymorphisms (SNPs) rs1421085T>C, rs9939609T>A, rs8057044G>A and copy number variation (CNV) was evaluated in association with childhood obesity or overweight status in children with Mayan ethnicity.MethodsWe included 318 school‐aged children with obesity or overweight status (body mass index [BMI]: >85th percentile) and 303 children with normal weight (BMI: 15th‐85th percentile). Genotyping was performed using real‐time polymerase chain reaction (RT‐PCR) with TaqMan probes. The cross‐sectional study was carried out using univariate and multivariate logistic regression models adjusted for gender.Results
FTO‐SNP rs1421085 showed significant differences between children with obesity and children with normal weight for the heterozygous genotype (P = 0.003) and for allele frequencies (P = 0.023). Adjusting by gender, significant differences were found in frequencies of the hetezygous genotype of SNPs rs9939609 (P = 0.023) and rs1421085 (P = 0.003) as well as in allele frequencies (P = 0.042 and P = 0.013, respectively) between girls with obesity and girls without obesity. In contrast, SNP rs8057044 was significantly different only between heterozygous overweight versus normal weight boys (P = 0.035) and for the allele frequency of rs8057044 (P = 0.021). The mean relative CNV was significantly higher in male overweight children than in boys with normal weight (P = 0.000).ConclusionsThe FTO SNP rs1421085 is a genetic factor associated with obesity in Mayan school‐aged children. FTO SNPs rs1421085 and rs9939609 affect genetic susceptibility for obesity only in girls, whereas, SNP rs8057044 and CNV are associated with overweight status only in boys.
Genotype and phenotype correlations for SHANK3 de novo mutations in neurodevelopmental disorders
Authors: Li Ying , Jia Xiangbin , Wu Huidan , Xun Guanglei , Ou Jianjun , Zhang Qiumeng , Li Honghui , Bai Ting , Hu Zhengmao , Zou Xiaobing , Xia Kun , Guo Hui 
Published: December 2018

AbstractSHANK3 has been identified as the causative gene of 22q13.3 microdeletion syndrome phenotype. De novo mutations (DNMs) of SHANK3 were subsequently identified in patients with several neurodevelopmental disorders, including autism spectrum disorders (ASDs), schizophrenia (SCZ), a Rett syndrome‐like phenotype, and intellectual disability (ID). Although broad developmental phenotypes of these patients have been described in single studies, few studies have reviewed the genotype and phenotype relationships using a relatively large cohort of patients with SHANK3 DNMs. In this study, we identified a de novo splice mutation (NM_033517.1: c.2265+1G>A) that functionally impairs mRNA splicing, produces multiple splice variants, and results in the reduction of the amounts of mRNA. To analyze the genotype and phenotype correlations for SHANK3 DNMs, we reviewed 37 previously published patients with 28 SHANK3 DNMs. Our results revealed that haploinsufficiency of SHANK3 causes a broad spectrum of neurodevelopmental phenotypes with impaired social interaction, repetitive behavior, speech impairment, ID, and regression as the most common observations. Seizures, hypotonia, global development delay, dysmorphic features, and several other features also occurred recurrently. Specific phenotypes are also observed in certain genotypes. Our study provides the frequency of the heterogeneous co‐occurring conditions caused by SHANK3 DNMs, which will be beneficial for diagnosis and clinical management.
Socioeconomic factors impact quality of life outcomes and olfactory measures in chronic rhinosinusitis
Authors: Beswick Daniel M. , Mace Jess C. , Rudmik Luke , Soler Zachary M. , Alt Jeremiah A. , Smith Kristine A. , Detwiller Kara Y. , Smith Timothy L. 
Published: December 2018

BackgroundHealthcare disparities related to socioeconomic factors may adversely impact disease states and treatment outcomes. Among patients with chronic rhinosinusitis (CRS), the impact of socioeconomic factors on outcomes following endoscopic sinus surgery (ESS) remains uncertain.MethodsAdult patients with refractory CRS were prospectively enrolled into an observational, multi‐institutional cohort study between March 2011 and June 2015. Socioeconomic factors analyzed included household income, insurance status, years of education completed, race, age, and ethnicity. Income was stratified according to the Thompson and Hickey model. The 22‐item Sino‐Nasal Outcome Test (SNOT‐22) and Brief Smell Identification Test (BSIT) were completed preoperatively and postoperatively.ResultsA total of 392 patients met inclusion criteria. Higher age and male gender were associated with better mean preoperative SNOT‐22 scores (both p < 0.02), whereas Medicare insurance status and male gender were associated with worse preoperative mean BSIT scores (both p < 0.02). Postoperatively, higher household income ($100,001+/year) and lower age were associated with a greater likelihood of improving at least 1 minimal clinically important difference (MCID) on SNOT‐22 scores (OR = 2.40 and 1.03, respectively, both p < 0.05), while no factors were associated with increased odds of achieving a MCID on BSIT scores.ConclusionsPreoperative olfactory function and postoperative quality of life (QOL) improvement were associated with metrics of socioeconomic status in patients with CRS electing ESS. The odds of experiencing a clinically meaningful QOL improvement were more than twice as likely for patients with the highest household income level compared to other income tiers. Further investigation is warranted to identify barriers to postoperative improvement.