bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial
Authors: Nomeikaite Auguste , Gelezelyte Odeta , Böttche Maria , Andersson Gerhard , Kazlauskas Evaldas 
Published: November 2024

Background
Prompts offer a promising strategy to promote client engagement in internet-delivered cognitive behavioral therapy (ICBT). However, if the prompts do not meet the needs of clients, they can potentially be more obtrusive rather than helpful.

Objective
The aim of this study was to test if prompts tailored based on timing and frequency, aligned with preintervention goal setting, can increase usage and the efficacy of a therapist-supported ICBT stress recovery intervention for health care workers.

Methods
The 2-arm randomized controlled trial included 87 health care workers (99% female, aged 19-68 years: mean 39.61, SD 11.49): 43 in the standard intervention group and 44 in the tailored prompts group. The primary outcome measure was the Recovery Experiences Questionnaire, and the secondary outcomes were the Perceived Stress Scale-4, the Patient Health Questionnaire-4, and the World Health Organization-5 Well-Being Index. The self-report data were collected before the intervention (September 2022), postintervention (October 2022), and 6-month follow-up (May 2023).

Results
The results showed that tailored prompts, although appreciated by the majority (39/40, 98%), did not improve intervention usage indicators, such as the number of logins (t85=–0.91; P=.36), modules opened (t83.57=–1.47; P=.15), modules completed (t85=–0.71; P=.48), exercises completed (t85=–1.05; P=.30), or the time spent using the program (χ22=1.1; P=.57). Similarly, tailored prompts did not increase the effects of the intervention in terms of stress recovery skills (Cohen d ranging from 0.31 to 0.85), perceived stress (d=–0.08; –0.70), depression (d=–0.11; –0.38), anxiety (d=–0.32; –0.64), or psychological well-being (d=0.26; 0.46). In addition, the standard intervention group showed greater long-term stress recovery effects than the group using the internet-delivered intervention supplemented by tailored prompts (β=–0.24, P=.03).

Conclusions
Although the study confirmed the efficacy of the program, the merits of tailored prompts in ICBT for stress recovery were not supported. Future research is needed to test the effects of the stress recovery intervention supplemented by goal setting and tailored prompts.

Trial Registration
ClinicalTrials.gov NCT05553210; https://clinicaltrials.gov/study/NCT05553210
Effectiveness of Using a Digital Wearable Plantar Pressure Device to Detect Muscle Fatigue: Within-Subject, Repeated Measures Experimental Design
Authors: Chen Fu-Yu , Lin Tzu-Yao , Huang Yi-Cheng , Widianawati Evina 
Published: November 2024

Abstract

Background
Muscle fatigue, characterized by reduced force generation during repetitive contractions, impacts older adults doing daily activities and athletes during sports activities. While various sensors detect muscle fatigue via muscle activity, biochemical markers, and kinematic parameters, a real-time wearable solution with high usability remains limited. Plantar pressure monitoring detects muscle fatigue through foot loading changes, seamlessly integrating into footwear to improve the usability and compliance for home-based monitoring.

Objective
This study aimed to investigate the effects of muscle fatigue on plantar pressure measurements using a self-developed wearable plantar pressure system.

Methods
Twelve healthy participants completed a 5-minute calf muscle fatigue protocol. The plantar pressures and surface electromyography (sEMG) activity of the gastrocnemius muscles were recorded before and after exercise. The plantar pressures at 6 regions and the median frequency (MDF) of sEMG were analyzed to quantify fatigue.

Results
The self-developed foot pressure system showed a significant decrease in plantar pressure peak values at the heel of the left (P=.003) and right feet (P=.001) and at the lateral toe of the left (P=.001) and right feet (P=.026). A significant increase was observed at the metatarsal head of both the left foot (P=.001) and the right foot (P=.017). The MDF of sEMG signals significantly decreased in the left (P=.001) and right gastrocnemius (P<.001).

Conclusions
Plantar pressure changes and sEMG signals effectively detect gastrocnemius muscle fatigue using the proposed wearable system, supporting the development of a wearable solution for detecting muscle fatigue suitable for home-use.
Prognosis of topography changes in the impact of floods (Itajubá/MG – Brazil)
Authors: Marciano Alexandre Germano , Barbosa Alexandre Augusto , Silva Alex Takeo Yasumura Lima , Reboita Michelle Simões , Silva Ana Paula Moni 
Published: November 2024

With increasing urbanization, some decision-makers often take inappropriate actions that affect the environment due to a lack of technical knowledge or personal interests. In the case of areas with recurrent flooding, irregular occupation can cause a series of environmental and economic problems. The Industrial District of the municipality of Itajubá-MG has been experiencing accelerated occupation and noticeable morphometric changes. To predict the impact of these changes in land use and occupation, this study seeks to establish flood diagnosis between 2005 and 2021, and project a future scenario until the year 2030. This article intends to assess the impacts caused by floods. The HEC-RAS software was utilized to simulate five flood propagations under six different occupation scenarios. Simulations were analyzed at eight control sites throughout the study area. The results indicate that, over the years, as a result of increasing occupation in this area, flood damming is expected to occur in the region upstream of the landfills. However, due to the proportionality of the area, these damming heights are considered irrelevant, as they do not exacerbate the damage caused by floods. In some cases, they even lead to a reduction in the flooded area in the Industrial District.
Pelatihan Pembuatan Mainan Edukasi Terhadap Peningkatan Pengetahuan Kader Posyandu dalam Stimulasi Perkembangan Balita
Authors: Kurniawati Ida , Witari Ni Putu Diah , Dewi A.A. Ayu Asri Prima , Kerans Fransiscus Fiano Anthony , Wangsa Putu Gde Hari , Adhitya I Putu Gde Surya 
Published: November 2024

Proses tumbuh kembang anak pada periode emas akan sangat menentukan fase tumbuh kembang anak selanjutnya. Deteksi dini dan stimulasi perkembangan anak perlu dilakukan secara berkala sebagai upaya untuk mengoptimalkan perkembangan dan mencegah masalah terkait yang dapat muncul pada anak. Penelitian ini bertujuan untuk memberikan pendampingan kepada mitra untuk meningkatkan keterampilan pembuatan mainan edukasi anak berbahan sederhana dan memberikan pengetahuan mengenai peranan mainan edukasi dalam stimulasi perkembangan anak. Penelitian ini merupakan penelitian deskriptif dengan menggunakan teknik pendekatan survey kepada masyarakat. Penelitian ini melibatkan subjek sebanyak 15 orang anak. Metode pelaksanaan PKM meliputi sosialisasi dan diskusi menggunakan Focus Group Discussion (FGD) untuk menentukan permasalahan di masyarakat. Adapun instrumen yang digunakan adalah panduang FGD. Setelah data dikumpulkan kemudian dianalisis menggunakan metode analisis deskriptif. Hasil penelitian ini yaitu terdapat peningkatan keterampilan mitra dalam pembuatan mainan edukasi untuk stimulasi perkembangan anak. Sehingga dapat disimpulkan bahwa, pelatihan pembuatan mainan edukasi anak dapat meningkatkan kemampuan peserta untuk berkreasi dalam membuat mainan edukasi anak berbahan sederhana Penelitian ini memiliki dampak positif terhadap peningkatan pengetahuan bagi kader posyandu terkait pembuatan mainan edukatif untuk stimulasi tumbuh kembang balita. Permainan edukatif sangat bermanfaat dalam proses perkembangan anak.
PKM Implementasi Aplikasi Asesmen Profil Kepemimpinan Pembelajaran Untuk Pendidikan Berkelanjutan Menuju Profesionalisme Guru
Authors: Susanto Ratnawati , Yulhendri  , Mulyo Wiharto  
Published: November 2024

Kesulitan guru untuk mempersiapkan kemapanan karir secara berkualitas dalam peran mengajar, belajar dan berkarya sesuai dengan kebutuhan, tuntutan dan tantangan kebijakan Platform Merdeka Mengajar (PMM), kebutuhan pelatihan, kebutuhan pengukuran kinerja serta pencapaian visi misi sekolah dengan keunggulan pembelajaran yang memastikan layanan pendidikan untuk pembentukan kecerdasan, bakat dan minat siswa. Profesionalisme guru melalui pendidikan berkelanjutan menjadi pilar penyelenggaraan. Kegiatan PKM menyikapinya dengan 3 bidang fokus kebutuhan: manajemen pendidikan, teknologi informasi dan komunikasi pendidikan, serta bidang Kesehatan, gizi dan hidup bersih. Sasaran: kepala sekolah, guru, orang tua dan peserta didik baru kelas 1 berfokus pada cara inovatif dan kreatif guru dalam menentukan strategi peningkatan manajemen frame work life cycle dan kepemimpinan pembelajaran. Metode pelaksanaan: Pre-Post test, diskusi, sosialisasi, coaching, praktek, observasi, pelatihan, dengan 5 tahap: Pra Pengkondisian, Sosialisasi, Pelatihan dan Penerapan Teknologi, Pendampingan dan evaluasi, dan Keberlanjutan Program. Tingkatan efektifitas capaian hasil PKM: (1) Pengetahuan dan keterampilan kepemimpinan pembelajaran dan Manajemen Karir Guru sebesar 89%, (2) Transformasi digital sebesar 100%, (3) Pengetahuan dan perilaku kesehatan, gizi dan hidup bersih siswa dan orang tua sebesar 85%, (4) 96% hasil umpan balik menyatakan program pemberdayaan mengatasi permasalahan. Kesimpulannya, Program PKM dapat dinyatakan efektif mengatasi permasalahan Kombel.
Aspects on Social Egg Freezing – Current State in Bulgaria
Authors: Dyulgerova-Nikolova D. , Antonova I. , Valkova L. , Timeva T. , Yunakova M. , Milachich T. 
Published: November 2024

Abstract

Problem statement
Oocyte cryopreservation for non-medical reasons has been widely promoted among young women who tend to delay their reproduction. As the methodology has proved its safety and efficiency in the field of assisted reproduction technology and the embryo laboratory, the interest in oocyte cryopreservation has increased highly. However, do social freezers ever come back and use these oocytes, or they keep them as a safety boat with no real near-future plans for reproduction?

Methods
The following study has been performed as a retrospective analysis of 296 women who had oocyte freezing procedure for non-medical (social) reasons, medical conditions (oncological treatment) and oocyte donation from January 2013 to June 2023 at Medical Complex Ob/Gyn “Dr Shterev” – Sofia, Bulgaria.

Results
Throughout the observed period, 190 women with 221 procedures vitrified their oocytes for future use. Only 9.47% of them had medical conditions and 7.36% were hindered to use their reproductive gametes at the day of the oocyte retrieval (absence of spermatozoa, sickness). The average age of the women in this group was 35.59 ± 1.5 years and the mean number of cryopreserved oocytes was 5.63 ± 1.4 per women. Compared to social cryopreserves, and bound to the Bulgarian legislation, the 106 women who donated their oocytes were younger (28.86 ± 1.5 years (p < 0.05)) with 7.34 ± 1.7 (p < 0.05) cryopreserved oocytes per donor. As the clinic has well represented program for oocyte donation 82.1% of the donors were used. In result, there were 37 clinical pregnancies with 47 children born. In the same period, only 46 (24.2%) women who stored their own gametes in our cryobank came back and claimed them for assisted reproduction. Nine clinical pregnancies had been registered and 10 children were born. An intriguing fact we can point from the medical history of the clear social freezers (SF) is the record of previous procedure(s) for abortion on demand. It was reported for 12% of the women in this group.

Conclusion
According to the results we observed as evident that patients need more clarity towards the procedures for oocyte cryopreservation and consequent fertility treatment. We should rise more awareness to the most preferable age for cryopreservation and number of oocytes to be stored.
Antibiotic Prescribing Practices to Children Among in- and Outpatient Physicians in Bulgaria
Authors: Zaykova K. , Nikolova S. P. , Pancheva R. , Serbezova A. 
Published: November 2024

Abstract
Assessing the particular trends and factors influencing antibiotic prescription practices for pediatric patients by inpatient and outpatient physicians in Bulgaria is essential for pinpointing areas needing improvement and devising strategies to encourage judicious use of antibiotics. The aim of this study is to offer practical insights for both hospital and outpatient care. By recognizing and comprehending the specific details of antibiotic usage in pediatric healthcare, this study seeks to facilitate the creation of tailored stew-ardship strategies to address the growing challenge of antimicrobial resistance. A cross-sectional, multicenter survey was conducted between September and November 2022, involving specialists from various medical fields. The study used a 4-point Likert scale to evaluate the most prevalent clinical scenarios in which antibiotics were prescribed. A total of 222 physicians participated in the survey, with 108 respondents chosen for analysis. Their primary patient population consisted of at least 25% children. The study’s results highlight notable variations in antibiotic prescription patterns between general practitioners and outpatient physicians in Bulgaria. Specifically, general practitioners were found to have a higher tendency to prescribe antibiotics before holidays or weekends compared to outpatient physicians. Moreover, GPs in Bulgaria displayed an increased likelihood of prescribing antibiotics when they had personal familiarity with the patient and did not consider further tests necessary. They also exhibited lower rates of prescribing antibiotics based on antibiogram and blood test results compared to outpatient physicians. Healthcare providers play a crucial role in addressing antimicrobial resistance, highlighting the necessity of their proactive participation in combating this global health concern. Despite being aware of the issue, there is need for additional education and interventions to enhance appropriate prescribing practices. The authors underline the significance of adopting a well-balanced approach to antibiotic prescription, taking into account both individual patient requirements and potential public health implications associated with antibiotic misuse.
Antimicrobial Susceptibility of Fructophilic Lactic Acid Bacteria on PHZM Gene of Pseudomonas Aeruginosa Isolates from Wounds Infected
Authors: Anwer A. W. , Ahmed M. E. 
Published: November 2024

Abstract

Introduction
The study was to isolate and characterize fructophilic lactic acid bacteria (FLAB) species from the honey bee gut. Based on the results of this study, it was found that the FLAB species obtained from honey were gram-positive and catalase-negative, and this identification was confirmed through 16S rRNA gene sequencing.

Materials and methods
The results indicated that yeast extract was the most effective nitrogen source, while glucose was the preferred carbon source for cell-free supernatant (CFS) production. The optimal pH for CFS production was found to be 5, and the incubation period of 72 hours was determined to be the most suitable for obtaining a high yield of CFS. Another aspect of the study aimed to identify multidrug-resistant P. aeruginosa isolates from burn wound infections. The isolates were identified using the VITEK 2 system, and the phzM gene was detected in all nine strains. Furthermore, the study evaluated the effect of the CFS of the selected strain (E5) on the expression of the phzM gene.

Results
The study showed a significant down-regulation of phzM gene expression in multidrug-resistant P. aeruginosa isolates following exposure to the CFS, indicating the potential of E. faecium as an effective antimicrobial agent against P. aeruginosa infections that are resistant to multiple drugs. We performed a primary screening to evaluate the effect of the CFS obtained from E. faecium (E5), and it was observed that the CFS showed a high inhibition zone of 23 mm against multidrug-resistant P. aeruginosa, as determined by the agar well diffusion assay. The study also investigated further to determine the optimal conditions for producing CFS.

Conclusion
Down-regulation and up-regulation in the expression of the genes following exposure to CFS indicate the potential of E. faecium as an effective antimicrobial agent against multi-drug resistant (MDR) P. aeruginosa infections.
Left Amyand’s Hernia in A 1-Year-Old Male Infant: Report of a Rare Case in Common Presentation
Authors: Fikri E. , Alnaz A. 
Published: November 2024

Abstract
Amyand’s hernia is a rare type of hernia with the appendix and cecum trapped in a hernial sac. A one-year-old male infant was referred with irreducible left inguinal hernia for about 1 week. No signs of intestinal obstruction were presented, and pain was tolerated. A herniotomy was performed on the patient. Intraoperatively, the appendix and cecum were found in the left hernial sac, which this rare presentation named left Amyand’s hernia. Cecum and appendix were considered normal. No perforation and significant inflammation were found; hence, no appendectomy was performed. Left Amyand’s hernia is a very rare case, mostly in pediatric surgery, in which the current decision of diagnosis-making can only be made intraoperatively.
Drug-Induced Liver Toxicity
Authors: Stavrakeva K. , Popova M. , Esad M. , Apostolova E. , Kokova V. , Bacelova M. , Alakidi A. , Bivolarska A. 
Published: November 2024

Abstract
The liver performs many vital functions such as regulating homeostasis, bile production, storage of vitamins, and more. Another important function of the liver is to neutralize toxic substances entering the body. Substances entering the human body can be eliminated unchanged, retained unchanged, or undergo chemical transformation. Drugs are one of the most important and common causes of hepatotoxicity. It can manifest in various forms, ranging from elevated serum levels of transaminases to acute liver failure. The mechanisms of drug-induced liver damage may include the formation of a toxic metabolite (paracetamol), induction of oxidative stress, mitochondrial damage, suppression of key transcription factors and enzymes (methotrexate), suppression of beta-oxidation (valproate), impaired bile secretion and others. In some cases, hepatotoxicity is an idiosyncratic type and the exact mechanism of damage is unclear. Due to the importance of the problem, knowledge about the metabolism, potential adverse drug reactions, and the correct dosage regimen is essential.
Bioconversion of hydroquinone to arbutin in F3K Digitalis purpurea cell line
Authors: Pop Carmen Elena , Vlase Ana-Maria , Coste Ana , Deliu Constantin , Tămaş Mircea , Casian Tibor , Vlase Laurian 
Published: November 2024

Abstract
The capacity of the F3K Digitalis purpurea cell line to biotransform hydroquinone into β-arbutin was tested. The experimental protocol involved the sequential addition of hydroquinone to the culture medium, and testing different precursor (4-, 5-, and 6 mM) and sucrose concentrations (3 % and 6 %) under different lighting conditions (16-hour photoperiod and darkness). The biotransformation process was positively influenced by the photoperiod regime and increased sucrose concentration. The highest arbutin production (1 g/L) has been achieved in cell suspensions fed with 6% sucrose and 5 mM hydroquinone, under 16 hours daily light exposure.
Preliminary studies on the allelopathic potential of two invasive species of Solidago against selected cereal weeds
Authors: Mołdoch Jarosław , Domaradzki Krzysztof 
Published: November 2024

Abstract
The European Union is currently pursuing a policy of moving away from synthetic plant protection products to natural ones. This is reflected in the search for natural substances that can replace them in agricultural production. Many studies indicate that invasive species of Solidago have such allelopathic potential. The aim of the study was to assess the effect of extracts of two Solidago species (Solidago gigantea L. and Solidago canadensis L.) on the growth and development of cereal weeds: Chenopodium album, Papaver rhoeas and Agrostemma githago. Using liquid chromatography coupled with mass spectrometry (LC - MS) techniques, the material (crude extract, phenolic and saponins fraction) was standardized and tested for allelopathic activity using the modified first generation biotest. The results indicate the phenolic fraction (20.04 mg/g dry weight of Solidago gigantea; 21.03 mg/g for Solidago canadensis) and saponin fraction (2.27 and 3.74 mg/g dry weight respectively). Both fractions from S. gigantea are characterized by high phytotoxicity in relation to Ch. album, causing over 90% reduction of its biomass in relation to the control. For P. rhoeas these differences are not so clear. Biomass reduction by the phenolic fraction was 20% and by the saponin fraction 50%. In the case of S. canadensis, allelopathic activity was not as pronounced and ranged from 20–40% for the saponin fraction relative to the P. rhoeas. The highest resistance to preparations made from both species of Solidago was demonstrated by A. githago.
Volatility Implications for Asset Returns Correlation
Authors: Ivanov Illia 
Published: November 2024

Abstract
Although there is an extensive literature on the impact of volatility on asset returns correlation, investigating this in relation to broad asset selection and in perspective of different timelines has received less attention. In comparison to the previous papers, we use a much broader set of 35 selected asset classes and used rolling returns for five different periods ranging from 3 months to 5 years to calculate rolling correlations, which was used further for regression analysis between rolling correlation and volatility index (VIX). Results showed more impact of volatility on the mid-term horizon, such as 1 year, possibly meaning that for longer periods, structural economic factors impact correlation significantly, while for shorter periods, immediate market reactions to events and short-term fluctuations reduce the impact of the correlation. Autocorrelation of residuals suggests that correlation follows trends, which is evidenced more in longer periods. The study contributes to existing literature by comparing the volatility impact across a broad range of assets and multiple time horizons, revealing that correlation is sensitive to time horizons – overall and in terms of responses to heightened volatility. Also, the impact of volatility is different over different time periods, with most impact for the mid-time horizon, such as 1 year.
Wine from Međimurje – from Rome to Decanter
Authors: Kalšan Janko 
Published: November 2024

Abstract
The paper ‘Međimurje Wine - From Rome to the Decanter’ provides a systematic overview of the exceptional tradition of wine production in Međimurje. As one of the most important economic branches for the people of Međimurje, as well as for numerous lords and rulers of the region between the Mura and Drava rivers, its roots date back to the Roman Empire. In the modern era, in the second half of the 20th and early 21st centuries, it was fully realised and presented to the world. The aim of this work, based on numerous sources, is to show the development and numerous changes in vine cultivation and wine production throughout its long history but also to tell the story of the connection of a large part of the Međimurje population with this economic branch. The fertile soil and climate, combined with new varieties and techniques, as well as the association of winemakers, have certainly contributed to the creation of Međimurje wines. This has resulted in an exceptional leap in quality and promotion, creating a consistency in the wines that has led to outstanding results recognised at both national and global levels.