bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymeric Iodine Transport Layer Enabled High Areal Capacity Dual Plating Zinc‐Iodine Battery
Authors: Yin Dandan , Li Boyang , Zhao Lanya , Gao Na , Zhang Yanan , Feng Jie , Cui Xiaofeng , Xiao Chunhui , Su Yaqiong , Xi Kai , Ding Shujiang , Zhao Hongyang 
Published: November 2024

AbstractIodine cathode in aqueous battery has drawn great attention due to its high energy density and high safety. However, iodine has extremely low conductivity of 1×10−7 S cm−1, which usually results in low specific capacity. In this work, a PVA‐hydrogel layer was designed to enhance the areal capacity of zinc‐iodine cell. The areal capacity of PVA‐hydrogel layer modified CNT cathode showed twice as higher capacity than that of pure CNT film in a dual‐plating cell, The significant enhancement of the capacity was attributed to the fast iodine transport in the PVA‐hydrogel layer. Besides, the strong interaction between PVA chain and polyiodide anions prevented the shuttle effect. The PVA modified CNT cathode could stably operate for over 3000 hours with remarkably higher capacity and cycle life. We analyzed the uniquely fast transport behavior of polyiodides in PVA hydrogel by in situ Raman spectroscopy, in situ optical micrography, as well as DFT calculations. It was found that the strong binding force together with lower dissociation energy of iodine on PVA chain is the dominate reason for reduced shuttle effect and fast polyiodide transport. As a result, the assembled PVA‐I2 pouch cells showed excellent performance in both dual‐plating cells and conventional‐type cells.
CO2‐Assisted Controllable Synthesis of PdNi Nanoalloys for Highly Selective Hydrogenation of Biomass‐Derived 5‐Hydroxymethylfurfural
Authors: Guo Ruichao , Zeng Yongjian , Lin Lu , Hu Di , Lu Chunqiang , Conroy Stuart , Zhang Suyu , Zeng Chen , Luo Huixia , Jiang Zhiwei , Zhang Xiaolei , Tu Xin , Yan Kai 
Published: November 2024

AbstractThe selective hydrogenation of 5‐hydroxymethylfurfural (HMF) to 2,5‐bishydroxymethyltetrahydrofuran (BHMTHF), a vital fuel precursor and solvent, is crucial for biomass refining. Herein, we report highly selective and stable PdNi nanoalloy catalysts for this deep hydrogenation process. A CO2‐assisted green method was developed for the controllable synthesis of various bimetallic and monometallic catalysts. The PdNi/SBA‐15 catalysts with various Pd/Ni ratios exhibited a volcano‐like trend between BHMTHF yield and Pd/Ni ratio. Among all catalysts tested, Pd2Ni1/SBA‐15 achieved the best performance, converting 99.0 % of HMF to BHMTHF with 96.0 % selectivity, surpassing previously reported catalysts. Additionally, the Pd2Ni1/SBA‐15 catalyst maintained excellent stability even after five recycling runs. Catalyst characterizations (e. g., HAADF‐STEM) and density functional theory (DFT) calculations confirmed the successful formation of the alloy structure with electron transfer between Ni and Pd, which accounts for the remarkable performance and stability of the catalyst. This work paves the way for developing highly selective and stable alloy catalysts for biomass valorization.
One‐Step Maleimide‐Based Dual Functionalization of Protein N‐Termini
Authors: Hanaya Kengo , Taguchi Kazuaki , Wada Yuki , Kawano Masaki 
Published: November 2024

AbstractMaleimide derivatives are privileged reagents for chemically modifying proteins through the Michael addition reaction with cysteine due to their selectivity, operational simplicity, and commercial availability. However, since accessible free cysteine is rarely found in natural proteins, it is highly desirable to find alternative targets to enable direct bioconjugation of proteins with maleimides. In this study, we have developed an operationally simple and straightforward method for the N‐terminal modification of proteins without the need for mutagenesis via a copper(II)‐mediated [3+2] cycloaddition reaction with maleimides and 2‐pyridinecarboxaldehyde (2‐PCA) derivatives under non‐denaturing conditions at pH 6 and 37 °C in aqueous media. Our method utilizes commercially available maleimides to attach diverse functionalities to various N‐terminal amino acids. We demonstrate the preparation of a ternary protein complex cross‐linked at the N‐termini and dually modified trastuzumab equipped with monomethyl auristatin E (MMAE), a cytotoxic agent, and a Cy5 fluorophore (MMAE‐Cy5‐trastuzumab). MMAE‐Cy5‐trastuzumab retained human epidermal growth factor receptor 2 (HER2) recognition activity and exerted cytotoxicity against HER2‐positive cells. Furthermore, MMAE‐Cy5‐trastuzumab allowed successful visualization of HER2‐positive cancer cells in mouse tumors. This straightforward method will expand the accessibility of protein conjugates with well‐defined structures in a wide range of research fields.
The first ontogenetic model for non‐crocodylomorph loricatans, based on osteohistology of the ontogenetic series of Prestosuchus chiniquensis from the Middle Triassic of Brazil
Authors: de Farias Brodsky Dantas Macedo , Carlisbino Thiago , Mastrantonio Bianca Martins , Desojo Julia Brenda , Schultz Cesar Leandro , Soares Marina Bento 
Published: November 2024

AbstractPrestosuchus chiniquensis is an iconic non‐crocodylomorph loricatan from the Brazilian Triassic beds and the best‐known taxon, represented by several specimens. The completeness and preservation of its skeleton make it a valuable taxon for paleobiological studies. We explore the microstructure of bone tissues of appendicular elements and ribs of three specimens of Prestosuchus to access a variety of aspects of its paleobiology, such as histovariability, ontogeny, and growth patterns. Integrating our data and other osteohistologically studied P. chiniquensis specimens, we proposed for the first time an ontogenetic model for non‐crocodylomorph loricatans. The model encompasses six distinct age classes (I–VI) that allow us to infer the growth patterns of P. chiniquensis and possibly expand to other phylogenetically close taxa. During early ontogeny (age classes I–II), sustained fast growth was maintained by a fibrolamellar complex. In mid ontogeny (age classes III–IV), highly vascularized parallel‐fibered bone predominates, suggesting intermediary growth rates. A change for a poorly vascularized parallel‐fibered/lamellar bone would mark the attainment of sexual (age classes IV–V) and skeletal maturity, comprising the age class VI. An external fundamental system (EFS) present in the outermost cortex is the main histological feature that characterize the age class VI. Major histovariability features are present between appendicular bones and ribs of skeletally immature individuals. The most prominent of them is the presence of fibrolamellar complex and highly vascularized parallel‐fibered bone in appendicular bones and poorly vascularized parallel‐fibered bone in ribs. In advanced ontogenetic stages, the histovariability between appendicular bones and ribs tends to be minor. Our data also support previous hypothesis of the presence of one new taxon among the specimens assigned to P. chiniquensis, increasing the diversity of non‐crocodylomorph loricatans. The new taxon, represented by the specimen UFRGS‐PV‐0152‐T, awaits a formal anatomical description. Our study advances the preliminary understand of the ontogeny and growth patterns of non‐crocodylomorphs loricatans and Pseudosuchia as a whole.
Enhancing cross‐cultural educational awareness: Experimental study on immersive experiences using virtual reality
Authors: Chen Qingwen 
Published: November 2024

AbstractThe current cross‐cultural education still faces problems such as low awareness and ability in cross‐cultural education, low cultural sensitivity, shallow awareness of cross‐cultural differences and poor cross‐cultural ability to cooperate with others. The significance of this study lies in enhancing awareness and abilities in cross‐cultural education to improve the current state of cross‐cultural education and promote cross‐cultural communication and understanding. The paper used Unity to build a virtual scene, and then selected 120 college students as research subjects and divided them into three classes: virtual reality immersive experience group (Class 1); traditional learning group (Class 2); and flipped classroom group (Class 3). A comparative experiment was designed. The research results found that the average scores of cultural differences and cultural conflict sensitivity among students in Class 1 reached 89.33 and 91.54, respectively. The average scores of cultural differences and cultural conflict sensitivity among students in Class 2 were 73.68 and 76.26, respectively. The average scores of cultural differences and cultural conflict sensitivity among students in Class 3 were 78.05 and 77.00, respectively. In addition, the cognitive depth and adaptability to cross‐cultural cooperation of Class 1 students who use immersive virtual reality experiences are significantly better than those of the other two classes. The research results indicate that using immersive virtual reality experiences for cross‐cultural education can help improve students' awareness and ability in cross‐cultural education, increase their cultural sensitivity, enhance their cognitive level of cultural differences and enhance their cross‐cultural cooperation ability.
Light Harvesting Materials: A Study on Förster Resonance Energy Transfer and Optoelectronic Properties of Potential Nerium oleander Flowers
Authors: Harshitha. D. , Kumar Anil , Renuka C. G. 
Published: November 2024

ABSTRACTThe present study focused on extracting the anthocyanin dyes in ethanol, acidic ethanol, methanol, and acidic methanol solvents from Nerium oleander flowers by a simple maceration extraction process. FTIR spectroscopy and vibrational studies have confirmed the existence of polyphenolic groups in 2‐phenyl chromenylium (anthocyanin) dyes. The optoelectronic results show the least direct bandgap (2.89 eV), indirect bandgap (1.98 eV), Urbach energy (0.120 eV), high refractive index (1.654), dielectric constant (3.294) and high optical conductivity (1.813 103 S/m) for the anthocyanin dye extracted found in acidic ethanol solvent. The photoluminescence properties such as Stokes' shift, quantum yield, and lifetime results show that anthocyanin dyes are promising candidates for red‐LEDs and optical materials. The excellent correspondence between the absorption and emission spectra reinforces that the anthocyanins are efficient (89%) FRET probes. Further, the donor and acceptor undergo redshift in excitation and emission spectra in all studied solvents. The photometric properties such as CIE, CRI, CCT and color purity results of anthocyanins in all studied solvents revealed that this material exhibits pink to red shades (x = 0.40 → 0.50 and y = 0.46 → 0.39) and is well suitable for have great potential in the manufacturing of Organic‐LEDs and other optoelectronic device applications.
A Simple and Rapid HPLC Method Development for Quantification of Sodium Benzoate Content in Chlorzoxazone Oral Solid Dosage Forms
Authors: Lankalapalli Prasanna Kumar , Kamireddy Teja , Sambu Pranitha 
Published: November 2024

ABSTRACTThe present study discusses the development of a simple, rapid, and specific HPLC method for the estimation of sodium benzoate in chlorzoxazone tablet dosage formulations. The current developed HPLC method was validated as per the current ICH guidelines. The chromatographic separation was achieved using a 0.02‐M phosphate buffer adjusted to pH 3.0 with orthophosphoric acid as the buffer. Mobile phase A consisted of 100% buffer, and mobile phase B was a mixture of acetonitrile and buffer in a ratio of 80:20 (v/v). The column temperature was maintained at 30°C, the sample cooler at 25°C, and the flowrate at 0.8 mL min−1. The injection volume was 10 μL. The UV detection was performed at 230 nm for Sodium benzoate. The validated HPLC method was highly specific, with linearity ranging between 1.2 and 7.5 μg/mL for sodium benzoate, and the correlation coefficient was found to be > 0.999. The method showed high accuracy, exceeding 97%. The results demonstrate the successful applicability of the current method for the estimation of sodium benzoate in marketed formulations, which can be extended to assess other formulation systems. The developed method was validated as per international ICH guidelines with respect to specificity, linearity, precision, accuracy, and robustness. The method was applied to the analysis of stability samples.
Exploring Antimalarial and Cytotoxic Activities of Hibiscus cannabinus and Corchorus capsularis Extracts Through In‐Vitro and In‐Silico Approaches
Authors: Brahma Mettle , Barooah Prajjalendra , Maruthi Mulaka 
Published: November 2024

ABSTRACTMalaria is an infectious disease, endemic to tropical and sub‐tropical regions causing half a million people's deaths every year. Bioactive compounds derived from medicinal plants are used to treat malaria disease and its complications. H. cannabinus and C. capsularis are two edible medicinal plants widely cultivated throughout the state of Assam in India. In this study, in‐vitro and in‐silico investigations were performed to explore the anti‐malarial activity of the plant extracts against Plasmodium falciparum with its validation of hemocompatibility on human RBC. We report H. cannabinus and C. capsularis extracts possess highly potent antimalarial activity against Plasmodium falciparum with IC50 values of 3.80 ± 0.3 and 7.90 ± 0.8 µg/mL, respectively. The plant extracts showed growth inhibition of A549 lung adenocarcinoma cells, no toxicity on non‐cancerous Vero cells, and no hemolytic activity on human RBCs. The GC‐MS analysis detected bioactive compounds 2‐pyrazoline‐3‐carboxylic acid; 5‐hydroxy‐1‐(4‐methyl benzoyl)‐5‐phen 5‐oxo‐1‐phenyl‐4H‐pyrazole‐3‐carboxylic acid; 9‐oximino‐2,7‐diethoxyfluorene; and nonane‐diamide, n, n'‐di‐benzoyloxy in H. cannabinus; and, (+)‐sesamin; tetrahydropyran‐4‐carboxylic acid, 4‐phenyl‐, (3‐chloro‐4‐methylphenyl; and safrole in C. capsularis. In in‐silico study, antimalarial compounds in the extracts were predicted to have good binding affinities with docking score of <−7.5 kcal/mol on Falcipain‐2, and Cytchrome c2 proteins that promotes the growth and invasion of P. falciparum.
Plant Origin Source, Content Profile and Bioactivity of Podophyllotoxin as an Important Natural Anticancer Agent
Authors: Liu Wei , Zhao Dan , Yin Dongxue , Duan Kai , Wang Zhihao 
Published: November 2024

ABSTRACTPharmacological studies have shown that podophyllotoxin (PTOX) has anti‐tumor, antiviral, and anti‐inflammatory effects. More and more derivatives of PTOX, such as VM‐26, NK‐611 and GL‐331, have gradually been synthesized and are widely used in clinical practice. Sinopodophyllum hexandrum rhizome is rich in PTOX, which is much higher than other PTOX source plants. At present, research on S. hexandrum mainly focuses on artificial cultivation, chemical composition, pharmaceutical value, and the biosynthesis pathway of PTOX. However, the researches are relatively scattered, and systematic review on PTOX is very limited. Therefore, this study performed a comprehensive investigation of the plant origin source, content profile, and biological activities to provide an integrated reference for in‐depth research and clinical application of PTOX in the fields of chemistry and pharmacy, which can promote the innovative use of S. hexandrum resources and research and development of new anticancer drugs.
Electro‐Oxidative Extraction of Methanol from Lignin Using a Three‐Dimensional Graphite Anode
Authors: Xiong Zichun , Kobayashi Kazuyo , Miyawaki Aki , Teranishi Shinya , Sawada Yoshiharu , Hibino Takashi 
Published: November 2024

AbstractThis paper reports an electrochemical approach that uses lignin as a resource for renewable and sustainable methanol production. The aromatic rings of lignin have methoxy substituents, which can be oxidatively demethylated to methanol by active oxygen produced at the anode. A graphite electrode fabricated in a sponge form provided sufficient reaction space for the lignin feedstock, efficiently generated active oxygen species from water, and considerably suppressed the overoxidation of methanol to carbon dioxide. As a result, the methanol yield reached approximately 70 % at a temperature of 75 °C, atmospheric pressure, and anode potential of +0.57 V. Another advantage of this technique is that hydrogen evolution reaction (HER) occurred at the cathode and the cathode potential was held at approximately −0.5 V during the HER. Therefore, the cell voltage required for lignin electrolysis was 1.1 V or lower, which means that hydrogen as well as methanol was produced under mild conditions.
Recent Advances in the Development of Indolizine Scaffolds: Synthetic Methodology and Mechanistic Insights
Authors: Huang Jiuzhong , Li Chunsheng , Li Xiaoning , Li Guangyu , Yang Ziyi , Yu Yinke , Xie Yanping , Huang Hao , Yu Fuchao , He Zhihua 
Published: November 2024

Comprehensive SummaryIndolizine is a nitrogen‐containing heterocycle with strong aromaticity, possessing a delocalized 10π‐electron system. Based on the indolizine scaffolds, numerous molecules with biological activity and organic functional materials have been synthesized. Since 2016, over 110 papers have been published on the synthesis of indolizine scaffolds, but the reviews on synthesizing indolizine scaffolds have been incomplete and not up‐to‐date. Herein, from the perspective of the structure of indolizine with the combination of pyrrole and pyridine ring, we focus on the construction of indolizine scaffolds through the diversity of starting substrates, including pyridine derivatives (N1‐substituted pyridinium salt derivatives, C2‐substituted pyridine derivatives, N1‐ and C2‐free substituted pyridine derivatives), pyrrole derivatives and unoriginal ring substrates. Furthermore, the corresponding reaction mechanisms of synthetic methodologies are also elaborated. Therefore, this review not only paves the way for indolizine synthesis but also provides insight into exploring new reaction modes for constructing nitrogen‐containing heterocycles.
Key ScientistsIndolizine was discovered by Angeli in 1890 and first prepared by Scholtz in 1912 from α‐picoline and acetic anhydride. A general approach was developed by Chichibabin in 1927, that is of practical value for the preparation of 2‐alkyl‐ or 2‐arylindolizines. The Chichibabin reaction was the ring closure of quaternary pyridinium halides. At the begining of the 21st century, Basavaiah introduced a new dimension in the Baylis‐Hillman chemistry leading to a novel facile convenient methodology for synthesis of indolizine scaffolds in one‐pot operation. In 2010, Barluenga reported Cu(I)‐catalyzed regioselective [3+2] cyclization of unsubstituted pyridines toward alkenyldiazoacetates leading to functionalized indolizine derivatives, that was the first successful example of metal‐catalyzed cyclization of a π‐deficient heterocyclic system with alkenyldiazo compounds. In 2019 and 2022, Xi and Liu exploited the methods of non‐pyridine derivatives as starting materials to synthesize indolizines, respectively. In 2022, Guo developed an environmentally benign electrooxidative approach for constructing formyl‐ and acyl‐substituted indolizines.
Polymer Degradation via a Mechanochemical Gating Strategy
Authors: Liang Xiaojing , Qian Hai 
Published: November 2024

AbstractThe extensive use of plastics, valued for their lightweight, durability, and cost‐effectiveness, has led to severe environmental pollution, with 72% of plastic waste ending up in landfills or natural habitats. Traditional methods for plastic decomposition, including both mechanical and chemical approaches, often face challenges such as incomplete degradation and stability concerns. The innovative concept of mechanical gating presents a promising solution by incorporating mechanophores into polymer structures, enabling controlled degradation. Recent advancements have focused on utilizing mechanophores, such as cyclobutane, as "door locks" to regulate the degradation process. This perspective highlights recent progress in this field, demonstrating the potential of mechanophore‐based strategies for achieving on‐demand polymer degradation. It addresses the limitations of conventional recycling methods and explores how this approach can balance polymer stability with environmental degradability, paving the way for more sustainable plastic management solutions.Early Day Record
Influencers and prosocial luxury dynamics
Authors: Cenizo Coral 
Published: November 2024

AbstractProsocial and sustainable behaviors have emerged as key elements for luxury brands today, catalyzing a significant transformation in their strategies. In this context, the present study investigates whether influencers are reflecting these brands' efforts to align their image with ethical and sustainable values and, if so, determining the engagement level generated by such posts. Two types of analysis are employed on social media content: topic analysis using Latent Dirichlet Allocation and regression. The findings indicate that influencers do mention issues related to the prosocial and sustainable domain when discussing luxury brands, although not predominantly. However, these types of posts do not generate higher engagement, with this indicator being moderated by the type of influencer. These results challenge the effectiveness of prosocial content, underscoring the need for a more nuanced evaluation. In the business sphere, brands must strategically consider the inclusion of prosocial and sustainable content, tailoring their approaches based on the influencer type to optimize the impact on engagement.
A Solid Electrolyte Based on Sodium‐Doped Li4‐xNaxTi5O12 with PVDF for Solid State Lithium Metal Battery
Authors: Chen Qiyue , Lv Haitao , Peng Jun , Zhou Qi , Wu Wenzhuo , Wang Jing , Liu Lili , Fu Lijun , Chen Yuhui , Wu Yuping 
Published: November 2024

AbstractSolid‐state batteries (SSBs) present a potential pathway for advancing next‐generation lithium batteries, characterized by exceptional energy density and enhanced safety performance. Solid‐state electrolytes have been extensively researched, yet an affordable option with outstanding electrochemical performance is still lacking. In this work, Li4‐xNaxTi5O12 (LNTO)‐based composite solid electrolytes (CSEs) were developed to enhance the interface stability and electronic insulation. The CSE is composed of Li3.88Na0.12Ti5O12 (LNTO3) and poly (vinylidene fluoride) (PVDF) with a proportion of 20 wt % exhibited high ionic conductivity (4.49×10−4 S cm−1 at a temperature value equal to 35 °C), high ionic transfer number (equal to 0.72), low activation energy (equal to 0.192 eV), and favorable compatibility with the Li metal anode. The Li|LNTO3|LiFePO4 cell, tested at a 0.5 C current density, demonstrated 154.5 mAh g−1 of outstanding cycling stability for 200 cycles, capacity retention of 97.6 % along with a Coulombic efficiency of over 99 %, as well as a significant average specific capacity of 127.8 mAh g−1 over 400 cycles at 5 C. The Li|LNTO3|LiNi0.8Co0.1Mn0.1O2 (NCM811) cell could also operate over 100 cycles at 1 C. This study offers an effective method for preparing commercial CSEs for SSBs.