bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthy and sustainable diets for future generations
Authors: Green Hilary , Broun Pierre , Cook Douglas , Cooper Karen , Drewnowski Adam , Pollard Duncan , Sweeney Gary , Roulin Anne 
Published: February 2018

AbstractGlobal food systems will face unprecedented challenges in the coming years. They will need to meet the nutritional needs of a growing population and feed an expanding demand for proteins. This is against a backdrop of increasing environmental challenges (water resources, climate change, soil health) and the need to improve farming livelihoods. Collaborative efforts by a variety of stakeholders are needed to ensure that future generations have access to healthy and sustainable diets. Food will play an increasingly important role in the global discourse on health. These topics were explored during Nestlé's second international conference on ‘Planting Seeds for the Future of Food: The Agriculture, Nutrition and Sustainability Nexus’, which took place in July 2017. This article discusses some of the key issues from the perspective of three major stakeholder groups, namely farming/agriculture, the food industry and consumers. © 2018 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Allergenicity of acrolein‐treated shrimp tropomyosin evaluated using RBL‐2H3 cell and mouse model
Authors: Lv Liangtao , Lin Hong , Li Zhenxing , Ahmed Ishfaq , Mi Nasha , Chen Guanzhi 
Published: February 2018

AbstractBACKGROUNDFood processing effects can modify protein functional properties. However, protein was oxidized inevitably by lipid peroxidation during food processing. Acrolein, a primary by‐product of lipid peroxidation, can modify the structural and functional properties of protein. The aim of the research was to analyze the effect of acrolein on allergenicity of TM, a major allergen in shrimp.RESULTSThe overall allergenic effects of acrolein‐treated TM were evaluated using female BALB/c mice and a mediator‐releasing RBL‐2H3 cell line. Acrolein‐treated TM significantly decreased TM‐specific immunoglobulin E/G1 levels, and histamine and mMCP‐1 release in mouse serum. Release of inflammatory mediators such as β‐hexosaminidase, histamine, cysteinyl leukotriene and prostaglandin D2 was clearly suppressed after acrolein treatment.CONCLUSIONThese results indicate that acrolein‐induced tropomyosin modification can decrease the allergenicity of TM. This reduction contributes to allergenic potential changes in shrimp during processing and preservation. © 2018 Society of Chemical Industry
Honey adulteration detection: voltammetric e‐tongue versus official methods for physicochemical parameter determination
Authors: Oroian Mircea , Paduret Sergiu , Ropciuc Sorina 
Published: February 2018

AbstractBACKGROUNDThe aim of this study was to evaluate the usefulness of a voltammetric e‐tongue (three electrodes: reference electrode (Ag/AgCl), counter electrode (glassy carbon electrode rod) and working electrode (Au, Ag, Pt and glass electrode)) for honey adulteration detection. For this purpose, 55 samples of authentic honey (acacia, honeydew, sunflower, Tilia and polyfloral) and 150 adulterated ones were analyzed. The adulteration was made using fructose, glucose, inverted sugar, hydrolyzed inulin syrup and malt wort at different percentages: 5%, 10%, 20%, 30%, 40% and 50%, respectively. The e‐tongue has been compared with the physicochemical parameters (pH, free acidity, electrical conductivity (EC) and CIEL*a*b* parameters (L*, a* and b*)) in order to achieve a suitable method for the classification of authentic and adulterated honeys.RESULTSThe e‐tongue and physicochemical parameters reached a 97.50% correct classification of the authentic and adulterated honeys. In the case of the adulterated honey samples, the e‐tongue achieved 83.33% correct classifications whereas the physicochemical parameters only achieved 73.33%.CONCLUSIONThe e‐tongue is a fast, easy and accurate method for honey adulteration detection which can be used in situ by beekeepers and provide useful information on EC and free acidity. © 2018 Society of Chemical Industry
Size‐selective purification of hepatitis B virus‐like particle in flow‐through chromatography: Types of ion exchange adsorbent and grafted polymer architecture
Authors: Ng Hon Wei , Lee Micky Fu Xiang , Chua Gek Kee , Gan Bee Koon , Tan Wen Siang , Ooi Chien Wei , Tang Siah Ying , Chan Eng Seng , Tey Beng Ti 
Published: February 2018

AbstractHepatitis B virus‐like particles expressed in Escherichia coli were purified using anion exchange adsorbents grafted with polymer poly(oligo(ethylene glycol) methacrylate) in flow‐through chromatography mode. The virus‐like particles were selectively excluded, while the relatively smaller sized host cell proteins were absorbed. The exclusion of virus‐like particles was governed by the accessibility of binding sites (the size of adsorbents and the charge of grafted dextran chains) as well as the architecture (branch‐chain length) of the grafted polymer. The branch‐chain length of grafted polymer was altered by changing the type of monomers used. The larger adsorbent (90 μm) had an approximately twofold increase in the flow‐through recovery, as compared to the smaller adsorbent (30 μm). Generally, polymer‐grafted adsorbents improved the exclusion of the virus‐like particles. Overall, the middle branch‐chain length polymer grafted on larger adsorbent showed optimal performance at 92% flow‐through recovery with a purification factor of 1.53. A comparative study between the adsorbent with dextran grafts and the polymer‐grafted adsorbent showed that a better exclusion of virus‐like particles was achieved with the absorbent grafted with inert polymer. The grafted polymer was also shown to reduce strong interaction between binding sites and virus‐like particles, which preserved the particles’ structure.
Simultaneous identification and quantification of bisphenol A and 12 bisphenol analogues in environmental samples using precolumn derivatization and ultra high performance liquid chromatography with tandem mass spectrometry
Authors: Wang Zhonghe , Yu Jing , Yao Jiaxi , Wu Linlin , Xiao Hang , Wang Jun , Gao Rong 
Published: February 2018

AbstractA method for the identification and quantification of bisphenol A and 12 bisphenol analogues in river water and sediment samples combining liquid–liquid extraction, precolumn derivatization, and ultra high‐performance liquid chromatography coupled with tandem mass spectrometry was developed and validated. Analytes were extracted from the river water sample using a liquid–liquid extraction method. Dansyl chloride was selected as a derivatization reagent. Derivatization reaction conditions affecting production of the dansyl derivatives were tested and optimized. All the derivatized target compounds were well separated and eluted in 10 min. Dansyl chloride labeled compounds were analyzed using a high‐resolution mass spectrometer with electrospray ionization in the positive mode, and the results were confirmed and quantified in the parallel reaction monitoring mode. The method validation results showed a satisfactory level of sensitivity. Linearity was assessed using matrix‐matched standard calibration, and good correlation coefficients were obtained. The limits of quantification for the analytes ranged from 0.005 to 0.02 ng/mL in river water and from 0.15 to 0.80 ng/g in sediment. Good reproducibility of the method in terms of intra‐ and interday precision was achieved, yielding relative standard deviations of less than 10.1 and 11.6%, respectively. Finally, this method was successfully applied to the analysis of real samples.
Simple determination of some antidementia drugs in wastewater and human plasma samples by tandem dispersive liquid–liquid microextraction followed by high‐performance liquid chromatography
Authors: Mirparizi Ehsan , Rajabi Maryam , Asghari Alireza 
Published: February 2018

AbstractIn this work, a simple method, namely, tandem dispersive liquid–liquid microextraction, with a high sample clean‐up is applied for the rapid determination of the antidementia drugs rivastigmine and donepezil in wastewater and human plasma samples. This method, which is based on two consecutive dispersive microextractions, is performed in 7 min. In the method, using a fast back‐extraction step, the applicability of the dispersive microextraction methods in complicated matrixes is conveniently improved. This step can be performed in less than 2 min, and very simple tools are required for this purpose. To achieve the best extraction efficiency, optimization of the variables affecting the method was carried out. Under the optimized experimental conditions, the relative standard deviations for the method were in the range of 6.9–8.7%. The calibration curves were obtained in the range of 2–1100 ng/mL with good correlation coefficients, higher than 0.995, and the limits of detection ranged between 0.5 and 1.0 ng/mL.
Investigation of the chromatographic regulation properties of benzyl groups attached to bridging nitrogen atoms in a calixtriazine‐bonded stationary phase
Authors: Zhao Wenjie , Lou Xuhua , Guo Jizhao , Sun Peijian , Jia Yunzhen , Zheng Limei , He Lijun , Zhang Shusheng 
Published: February 2018

AbstractTwo reversed‐phase/anion‐exchange mixed‐mode stationary phases for high‐performance liquid chromatography using calixtriazines as chromatographic ligands were investigated with Tanaka test solutes, monosubstituted benzenes, aromatic positional isomers, and inorganic anions. Calixtriazine as a chromatographic ligand has been reported previously, but the benzylated nitrogen‐bridged calixtriazine‐bonded silica gel reported in this study is new. The experimental data showed that the calixtriazine platform is a unique chromatographic selector because its multiple active sites are available for different solutes and its chromatographic selectivity could be tuned by introducing substituent on the bridging nitrogen atoms present in the calixtriazine matrix. The synergistic effects of aromatic rings, nitrogen atoms, benzyl groups, and tunable cavity in the host molecule influenced the separation selectivity by multiple retention mechanisms. Such hybrid stationary phases provide more versatility and have great potential in the analysis of complex samples. Moreover, the synthetic protocols presented herein may provide an alternative understanding on macrocyclic host–guest chemistry, leading to new and selective separation media.
Reviewing smokeless tobacco epidemiology, carcinogenesis, and cessation strategy for otolaryngologists
Authors: Stanisce Luke , Levin Kristin , Ahmad Nadir , Koshkareva Yekaterina 
Published: February 2018

Objectives/ObjectivesWe aimed to provide an otolaryngologist‐targeted summary regarding the epidemiology, carcinogenesis, and cessation strategies for smokeless tobacco usage.Study DesignEvidence‐based literature review.MethodsWe reviewed the current evidence‐based literature concerning trends in smokeless tobacco use, associations with neoplastic change, and therapeutic interventions to assist with sustained abstinence. In complement, we present an actual case of laryngeal squamous cell carcinoma in the setting of chronic tobacco‐dentifrice usage in a lifelong nonsmoker.ResultsThis report provides a synopsis of epidemiological data and evidence‐based recommendations for general, pharmaceutical, and behavioral cessation strategies.ConclusionsSmokeless tobacco use continues to be prevalent among patients seen by otolaryngologists, particularly of various Indian and Southeast Asian descent. The data presented in this article will aid in the identification of at risk patients. The provided recommended cessation strategies will tool otolaryngologists for patient counseling and management, ultimately aimed at improving health outcomes. Laryngoscope, 128:2067–2071, 2018
Dural recurrence among esthesioneuroblastoma patients presenting with intracranial extension
Authors: Yu Yao , El‐Sayed Ivan H. , McDermott Michael W. , Theodosopoulos Philip V. , van Zante Annemieke , Kased Norbert , Glastonbury Christine M. , Garsa Adam A. , Yom Sue S. 
Published: February 2018

ObjectiveTo quantify the rate of late intracranial recurrences among esthesioneuroblastoma patients treated with surgical resection and postoperative radiation.Study DesignRetrospective review.MethodsAll patients receiving definitive‐intent therapy for esthesioneuroblastoma between March 1995 and September 2015 were reviewed. Presenting disease extent was categorized based on radiologic, operative, and pathologic findings. Between‐group survival differences were assessed using Kaplan‐Meier method and log‐rank test. Multivariate analyses were performed using Cox proportional hazards model.ResultsOf 38 patients initially treated at our institution, 53% (20 of 38) presented with intracranial extension. At a median follow‐up of 90 months (range, 6–199), 37% (14 of 38) recurred; 5‐ and 8‐year disease‐free survival rates were 69% and 54%; and overall survival rates were 81% and 72%, respectively.Among these patients, the dura was the most commonly involved site of relapse (8), followed by local (6), regional (5), and distant extracranial (3) sites; and five patients had ≥ two categories of failure. Eight‐year dural disease‐free survival was 57% versus 90% (P = 0.017) and 0% versus 87% (P < 0.0001), with and without intracranial extension and subtotal resection, respectively.Of six patients treated at recurrence, five (83%) experienced dural‐based failure such that, among all 44 patients, 13 (65%) of 20 recurrences involved the dura. After dural recurrence, the median survival time was 42 months (range, 12–125); salvage treatments were effective in rare cases of isolated low‐volume recurrence.ConclusionEsthesioneuroblastoma patients presenting with intracranial extension are at substantial and unique risk for long‐term dural‐based relapse.Level of Evidence4. Laryngoscope, 128:2226–2233, 2018
Can morphology reliably distinguish between the copepods Calanus finmarchicus and C. glacialis, or is DNA the only way?
Authors: Choquet Marvin , Kosobokova Ksenia , Kwaśniewski Sławomir , Hatlebakk Maja , Dhanasiri Anusha K. S. , Melle Webjørn , Daase Malin , Svensen Camilla , Søreide Janne E. , Hoarau Galice 
Published: February 2018

AbstractCopepods of the genus Calanus play a key role in marine food webs as consumers of primary producers and as prey for many commercially important marine species. Within the genus, Calanus glacialis and Calanus finmarchicus are considered indicator species for Arctic and Atlantic waters, respectively, and changes in their distributions are frequently used as a tool to track climate change effects in the marine ecosystems of the northern hemisphere. Despite the extensive literature available, discrimination between these two species remains challenging. Using genetically identified individuals, we simultaneously checked the morphological characters in use for C. glacialis and C. finmarchicus identification to compare the results of molecular and morphological identification. We studied the prosome length (1); the antennules and the genital somite pigmentation (2); the morphology of the fifth pair of swimming legs and of the mandible (3). Our results show that none of these morphological criteria can reliably distinguish between C. glacialis and C. finmarchicus. This has severe implications for our current understanding of plankton ecology as a large part of our knowledge of Calanus may be biased due to species misidentification and may subsequently require reinvestigation with the systematic use of molecular tools.
Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo‐controlled trial in breast cancer patients (TRANSDERMIS trial)
Authors: Robijns Jolien , Censabella Sandrine , Claes Stefan , Pannekoeke Luc , Bussé Lore , Colson Dora , Kaminski Iris , Bulens Paul , Maes Annelies , Noé Leen , Brosens Marc , Timmermans An , Lambrichts Ivo , Somers Veerle , Mebis Jeroen 
Published: February 2018

ObjectiveAcute radiodermatitis (RD) is a distressing and painful skin reaction that occurs in 95% of the patients undergoing radiotherapy (RT). The aim of this study was to evaluate the effectiveness of photobiomodulation therapy (PBMT) in the prevention of acute RD in breast cancer (BC) patients undergoing RT.MethodsThis study was a randomized, placebo‐controlled trial including 120 BC patients that underwent an identical RT regimen post‐lumpectomy. Patients were randomly assigned to the laser therapy (LT) or placebo group, with 60 patients in each group. Laser or placebo treatments were applied 2 days a week, immediately after the RT session, starting at the first day of RT. PBMT was delivered using a class IV MLS® M6 laser that combines two synchronized laser diodes in the infrared range (808–905 nm) with a fixed energy density (4 J/cm2). Skin reactions were scored based on the criteria of the Radiation Therapy Oncology Group (RTOG) and the Radiation‐Induced Skin Reaction Assessment Scale (RISRAS). The patients completed the Skindex‐16 questionnaire to evaluate their quality of life. All the measurements were collected at the first day, at a RT dose of 40 Gray (Gy), and at the end of RT (total dose 66 Gy).ResultsAt a RT dose of 40 Gy, there was no significant difference between the groups in the distribution of RTOG grades. However, at the end of RT the severity of the skin reactions significantly differed between the two groups (P = 0.004), with a larger percentage of patients experiencing RTOG grade 2 or higher (e.g., moist desquamation) in the placebo group (30% vs. 6.7%, for the placebo and laser group, resp.). The objective RISRAS score confirmed these results. In addition, the Skindex‐16 and RISRAS subjective score demonstrated that the patients’ quality of life was significantly better in the LT than in the control group.ConclusionsThe results of this trial show that PBMT is an effective tool to prevent the development of grade 2 acute RD or higher in BC patients. In addition, it also reduces the patients’ symptoms related to RD. Lasers Surg. Med. 50:763–771, 2018. © 2018 Wiley Periodicals, Inc.
Directional communication during movement execution interferes with tremor in Parkinson's disease
Authors: Naros Georgios , Grimm Florian , Weiss Daniel , Gharabaghi Alireza 
Published: February 2018

ABSTRACTBackground: Both the cerebello‐thalamo‐cortical circuit and the basal ganglia/cortical motor loop have been postulated to be generators of tremor in PD. The recent suggestion that the basal ganglia trigger tremor episodes and the cerebello‐thalamo‐cortical circuitry modulates tremor amplitude combines both competing hypotheses. However, the role of the STN in tremor generation and the impact of proprioceptive feedback on tremor suppression during voluntary movements have not been considered in this model yet.Objectives: The objective of this study was to evaluate the role of the STN and proprioceptive feedback in PD tremor generation during movement execution.Methods: Local‐field potentials of the STN as well as electromyographical and electroencephalographical rhythms were recorded in tremor‐dominant and nontremor PD patients while performing voluntary movements of the contralateral hand during DBS surgery. Effective connectivity between these electrophysiological signals were analyzed and compared to electromyographical tremor activity.Results: There was an intensified information flow between the STN and the muscle in the tremor frequencies (5‐8 Hz) for tremor‐dominant, in comparison to nontremor, patients. In both subtypes, active movement was associated with an increase of afferent interaction between the muscle and the cortex in the β‐ and γ‐frequencies. The γ‐frequency (30‐40 Hz) of this communication between muscle and cortex correlated inversely with electromyographical tremor activity.Conclusions: Our results indicate an involvement of the STN in propagation of tremor‐related activity to the muscle. Furthermore, we provide evidence that increased proprioceptive information flow during voluntary movement interferes with central tremor generation. © 2018 International Parkinson and Movement Disorder Society
GIAO‐DFT calculation of 15N NMR chemical shifts of Schiff bases: Accuracy factors and protonation effects
Authors: Semenov Valentin A. , Samultsev Dmitry O. , Krivdin Leonid B. 
Published: February 2018

15N NMR chemical shifts in the representative series of Schiff bases together with their protonated forms have been calculated at the density functional theory level in comparison with available experiment. A number of functionals and basis sets have been tested in terms of a better agreement with experiment. Complimentary to gas phase results, 2 solvation models, namely, a classical Tomasi's polarizable continuum model (PCM) and that in combination with an explicit inclusion of one molecule of solvent into calculation space to form supermolecule 1:1 (SM + PCM), were examined. Best results are achieved with PCM and SM + PCM models resulting in mean absolute errors of calculated 15N NMR chemical shifts in the whole series of neutral and protonated Schiff bases of accordingly 5.2 and 5.8 ppm as compared with 15.2 ppm in gas phase for the range of about 200 ppm. Noticeable protonation effects (exceeding 100 ppm) in protonated Schiff bases are rationalized in terms of a general natural bond orbital approach.
Quantifying precision in cardiac diffusion tensor imaging with second‐order motion‐compensated convex optimized diffusion encoding
Authors: Aliotta Eric , Moulin Kévin , Magrath Patrick , Ennis Daniel B. 
Published: February 2018

PurposeTo quantify the precision of in vivo cardiac DTI (cDTI) acquired with a spin echo, first‐ and second‐order motion‐compensated (M1M2), convex optimized diffusion encoding (CODE) sequence.MethodsFree‐breathing CODE‐M1M2 cDTI were acquired in healthy volunteers (N = 10) at midsystole and diastole with 10 repeated acquisitions per phase. 95% confidence intervals of uncertainty in reconstructed diffusion tensor eigenvectors (
,
,
), mean diffusivity (MD), fractional anisotropy (FA), and tensor Mode were measured using a bootstrapping approach. Trends in observed tensor metric uncertainty were evaluated as a function of scan duration, image SNR, cardiac phase, and bulk motion artifacts.ResultsFor midsystolic scans including 5 signal averages (scan time: ∼5 min), the median myocardial 95% confidence intervals of uncertainties were:
: 15.5 ± 1.2°,
: 31.2 ± 3.5°,
: 21.8 ± 3.1°, MD: 0.38 ± 0.02 × 10−3mm2/s, FA: 0.20 ± 0.01, and Mode: 1.10 ± 0.08. Uncertainty in all parameters increased for diastolic scans:
: 31.9 ± 7.1°,
: 59.6 ± 6.8°,
: 40.5 ± 6.4°, MD: 0.52 ± 0.09 × 10−3 mm2/s, FA: 0.23 ± 0.01, and Mode: 1.57 ± 0.11. Diastolic cDTI also reported higher MD (MDDIA = 1.91 ± 0.34 × 10−3 mm2/s vs. MDSYS = 1.58 ± 0.09 × 10−3 mm2/s, P = 8 × 10−3) and lower FA values (FADIA = 0.32 ± 0.06 vs. FASYS = 0.37 ± 0.03, P = 0.03) .ConclusioncDTI precision improved with increasing nondiffusion‐weighted (b = 0) image SNR, but gains were minimal for SNR ≥ 25 (∼10 averages). cDTI precision was also sensitive to intershot bulk motion artifacts, which led to better precision for midsystolic imaging.