bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consensus on Postoperative Recommendations After Transsphenoidal Surgery
Authors: Knappe Ulrich , Moskopp Dag , Gerlach Rüdiger , Conrad Jens , Flitsch Jörg , Honegger Jürgen 
Published: August 2018

Abstract
Background Guidelines for patient behavior following transsphenoidal surgery do not exist. To gain generally recommendations, the German pituitary working group conducted a study among pituitary surgeons to elucidate their opinions and customs of patients’ counselling.
Methods Questions concerning daily activities, exertion of sports and work life were addressed. It was asked to provide the postoperative time interval after which specific activities can be resumed both after a routine or an extended approach.
Results Fourteen pituitary surgeons returned the completed questionnaire. Following routine operations, washing the hair was allowed within one week, blowing the nose after 3, flying on an airplane and driving a car after one, lifting heavy weights after 4, playing wind instruments after 6, use of CPAP (continuous positive airway pressure) device after 3, permit leisure sports after 2 to 4 weeks (except for scuba diving). Competitive sports can be resumed after 6 weeks. Occupation with mental demands was considered feasible after 2 weeks, with physical labor after 4 weeks. After extended transsphenoidal surgery, the recommended time interval was roughly twice as long compared to the routine approach. Driving a car was allowed within the first 4 weeks after surgery by some pituitary surgeons, while others allow driving only after 3 months analogous to the regulations after craniotomy. The risk of scuba diving was considered high.
Conclusions The data of our study and the literature, and expert opinions from related scientific fields resulted in a consensus on recommendations for patients’ conduct to minimize risks after transsphenoidal surgery.
Augmented Procoagulant Activity in Cancer Patients, Treated with Recombinant Interferon-γ in Addition to Recombinant Tumor Necrosis Factor-α and Melphalan
Authors: Mulder André B , Zwaveling Jan H , Martin Smid W , Maring John K , van Ginkel Robert J , Girbes Armand R J , Schraffordt Koops Heimen , Meer Jan van der 
Published: August 2018

SummarySeveral investigators have reported that interferon-gamma (IFN³) can alter tumor necrosis factor alpha induced effects in vitro. We assessed in vivo effects of recombinant interferon-gamma (rIFN³) on recombinant tumor necrosis factor-alpha (rTNF±) induced activation of systemic blood coagulation in a non-randomized study in 20 consecutive cancer patients. Eight patients were treated with rIFN³ prior to and during hyperthermic isolated limb perfusion with rTNF± and melphalan (IFN³ group). They were compared with twelve patients who did not additionally receive rIFN³ (non-IFN³ group)Before start of perfusion, higher levels of TNFa, F1+2 and TAT levels were found in the IFN³ group. Fibrinogen and ATIII levels tended to be lower in this group. High TNF± levels, due to leakage during perfusion, were associated with activation of coagulation in all patients, that became obvious after the end of perfusion, when heparin treatment had been antagonized. Activation, measured by increased F1+2 and TAT levels, was significantly stronger in the IFN³y group. Monocytic TF remained low, possibly due to shedding of TF positive vesicles and/or sequestration of TF positive activated monocytes against the vessel wall. In both groups F1+2 and TAT levels declined 24 h after the perfusion, whereas monocytic TF increased to levels that were higher in the IFN³ group.In conclusion, our data confirm a strong activation of coagulation induced by rTNF± in cancer patients. They suggest that rIFN³ may lead to a slight activation of coagulation and augments TNFa induced procoagulant activity. These effects may be due to rIFN³ induced sustained monocytic TF activity.
Effect of Carbohydrate Modifications of Factor VIII/ von Willebrand Factor on Binding to Platelets
Authors: Goudemand Jenny , Mazurier Claudine , Samor B , Bouquelet S , Montreuil J , Goudemand M 
Published: August 2018

SummaryThis study compares the ability of unmodified and carbohydrate-modified forms of factor VIII/von Willebrand factor (FVIII/vWF) protein to bind to platelets in the presence of ristocetin or thrombin. Treatment of intact FVIII/vWF with α-D- neuraminidase results in more than 95% desialylation. Asialo FVIII/vWF retains total activity in ristocetin- and thrombin- mediated binding to platelets as demonstrated by direct and competitive binding assays. Examination of its multimeric pattern by sodium dodecyl sulfate-agarose electrophoresis reveals a normal multimeric structure. Treatment of intact FVIII/vWF with β-D-galactosidase results in the removal of 20% of galactose (agalacto FVIII/vWF) whereas 55% of galactose is released from asialo FVIII/vWF (asialo agalacto FVIII/vWF). Agalacto and asialo-agalacto FVIII/vWF are both unable to bind to platelets in the presence of ristocetin. In contrast, they still bind to thrombin- stimulated human (except thrombasthenic) platelets. Removal of either ultimate (agalacto FVIII/vWF) or ultimate and penultimate (asialo-agalacto FVIII/vWF) galactose results in the same loss of the larger molecular weight multimers and in an increase of smaller multimers. These results suggest (1) that sialic acid does not play a significant role in ristocetin- or thrombin-mediated FVIII/vWF-platelets interactions and multimeric structure of FVIII/vWF (2) that ultimate β-linked galactose residues are essential for the maintenance of a normal multimer organization (3) that ristocetin- and thrombin-mediated binding of FVIII/vWF to platelets differ in FVIII/vWF galactose requirement.
Immunologic Identification of the Cleavage Products from the Aα- and Bβ-Chains in the Early Stages of Plasmin Digestion of Fibrinogen
Authors: Liu C Y , Sobel Joan H , Weitz J I , Kaplan Karen L , Nossel H L 
Published: August 2018

SummaryFragment X components (Mr 225,000 to 333,000) were distinguished on sodium dodecyl sulfate polyacrylamide gels. Western blotting with monoclonal antibodies to Aα-chain segments demonstrated that the Aα-chains of fibrinogen and the largest fragment X components (Mr 285,000-340,000) contained both Aα 259-276 and Aα 540-554. Fragment X components of Mr 270.000-285,000 contained Aα 259-276 but lacked Aα 540-554, whereas the smallest fragment X components (Mr 225.000-270,000) contained neither Aα 540-554 nor Aα 259-276. Studies of the small peptides generated during fragment X formation complemented the studies of the large molecules, by demonstrating peptides containing both Aα 259-276 and Aα 540-554 (Mr 41,600-41,800 and Mr 38,700-38,900), peptides containing Aα 540-554 but not Aα 259-276 (Mr 20,500-21,000 and Mr 17,300-17,500) and peptides containing only Aα 259-276 (Mr 23,600-24,000 and Mr 20,500-21,000). Cleavage of Bβ 1-42 from the amino terminal ends of the Bβ-chains, measured with a specific radioimmunoassay, was linear until 1.6 moles per mole of fibrinogen had been relased, and coincided with loss of the central and carboxy terminal Aα-chain regions, i. e. Aα 259-276 and Aα 540-554. Based on present and previously reported data, a model is proposed for the evolution of the heterogenous group of fragment X derivatives from fibrinogen with the simultaneous release of small peptides. Features of this model include1. asymmetric cleavage of the fibrinogen dimer and2. proteolyses of several different bonds occurring simultaneously but at distinct rates.
A Monoclonal Antibody that Does Not Recognize Tissue-Type Plasminogen Activator Bound to Its Naturally Occurring Inhibitor
Authors: Schleef Raymond R , Wagner Nancy V , Sinha Manjula , Loskutoff David J 
Published: August 2018

SummaryHybridoma clones specific for tissue-type plasminogen activator (tPA) were screened in solid-phase radioimmunoassays for their reactivity toward free tPA and tPA complexed to the endothelial cell-derived, (3-migrating plasminogen activator inhibitor (β-PAI). Two monoclonal antibodies (MABs) were identified with quite distinct properties. The first, MAB LI72D1, bound to free tPA but did not recognize tPA complexed to the β-PAI, whereas the second, MAB HI72C1, bound both to free tPA and to tPA in complex with β-PAI. These properties were maintained when the MABs were immobilized to plastic micro- titer wells, thus permitting the development of immunoradiometric assays (IRMAs) to quantitate free tPA and total tPA antigen in various samples. The IRMAs were employed to analyze the tPA in media conditioned by several human cell types. The results indicate that in some cases, tPA may be present entirely as a free and active enzyme, while in others it apparently exists entirely in complex with β-PAI. Interestingly, some cells appear to contain both forms of tPA.
A Meta-Analysis of Arthroscopic Meniscal Repair: Inside-Out versus Outside-In versus All-Inside Techniques
Authors: Elmallah Randa , Jones LaRita C. , Malloch Lacy , Barrett Gene R. 
Published: August 2018

AbstractMeniscal repair has been introduced to preserve knee function and limit the accelerated degenerative changes associated with meniscal tissue resection. Arthroscopic techniques have evolved to improve morbidity. However, there are few clinical outcome studies in the peer-reviewed literature that compare the use of these approaches. Therefore, our purpose was to perform a meta-analysis of the existing literature on arthroscopic meniscal repair techniques. Specifically, we evaluated differences in: (1) operating time; (2) incidence of postoperative meniscal healing; (3) functional outcomes, using various scoring systems; and (4) incidence of complications. We searched the peer-reviewed literature using SCOPUS, Medline, EMBASE, and Web of Science. Eight studies were eligible for the meta-analysis. These included one prospective, randomized trial (level I), three prospective, comparative studies (level II), and four retrospective, comparative studies (level III). There were a total of 476 patients who had a mean follow-up between 3 and 156 months. When evaluating objective outcomes, the inside-out technique had a significantly higher mean operating time than the all-inside technique. The inside-out and all-inside techniques had comparable meniscal healing rates, but the outside-in repair had a significantly higher rate of meniscal healing than the all-inside repair. Upon assessment of functional outcomes, the inside-out and all-inside methods had comparable International Knee Documentation Committee and Tegner activity scores, but the all-inside method had greater improvements in Lysholm scores. The inside-out and all-inside repairs had similar overall complication rates. All-inside repair may demonstrate lower operating times, but the outside-in repair may have superior meniscal healing rates. Functional outcomes are overall comparable between the techniques. However, there are limited clinical data on the outcome differences between these procedures, and further comparative studies with longer follow-up are needed.
Combined Extradural and Intradural Pterional Transzygomatic Approach to Large Sphenoid Wing Meningiomas. Operative Technique and Surgical Results
Authors: González-Darder José M. 
Published: August 2018

Objectives Describe a unique and safe surgical procedure for the microsurgical management of large sphenoid wing meningiomas (SWMs) aimed to a radical resection of these tumors.
Design A prospective series of 26 cases with SWMs larger than 3 cm in one of its main diameter is presented. All patients were studied following the same clinical and imaging procedures. The surgical approach was through a pterional transzygomatic craniotomy. The surgical procedure has the following steps: 1. Extradural tumor devascularization and resection of the hyperostotic and/or infiltrated bone and then intradurally; 2. Intradural tumor debunking; 3. Microdissection of vascular branches and perforators from the capsule; 4. Identification of the optic and oculomotor nerves and internal carotid artery; 5. Tumor capsule dissection and resection; 6. Dural resection or cauterization; 7. Dural and bone reconstruction and closing.
Results All lesions were completely removed. Most complications were transient. The most relevant complication was a large middle cerebral artery infarct with permanent hemiplegia despite a decompressive craniotomy.
Conclusion Large SWMs can be considered as a single pathology regarding the surgical approach and intraoperative microsurgical procedure strategies. The pterional transzygomatic approach allows an extradural devascularization of the tumor and an extensive bone resection that facilitates the intradural stage of tumor resection. The proposed approach allows a wide and radical resection of the duramater and bone that increases the Simpson grade. However, surgery does not control other biological or molecular prognostic factors involved in tumor recurrence.
Telemonitoring of Neonatal Intensive Care Units: Preliminary Experience in the State of Minas Gerais, Brazil
Authors: Santos Alaneir , Alves Humberto , Queiroz Thaís , Silva Nara , Melo Maria 
Published: August 2018

Objective This article describes the implementation and functioning of a telemonitoring center of neonatal intensive care units (NICUs) organized by the Telehealth Center of the Medical School of the Federal University of Minas Gerais who signed an agreement with the Minas Gerais State Department of Health (SES/MG, in Portuguese), Brazil.
Study Design This is a descriptive retrospective study from December 2012 to June 2014 of a NICU telemonitoring project.
Results Twelve Web conferences have been performed. Six thousand, eight hundred and thirty nine (6,839) online teleconsultations of pediatricians and nurses with experience in neonatology and intensive care have been performed, of which 174 were with subspecialists, with an average response time of 6 hours.
Discussion The project has demonstrated to be satisfactory, with fast response in relation to the demands of subspecialists, promoting care, and management support to the NICU. The qualification via Web conferences prevents the displacement of the professionals to big centers for continuous medical education.
Conclusion The telemonitoring of NICU can contribute in the process of management, regulation of beds, reduction of displacements and transferences, adhesion to best practices, care support, and qualification of the involved professionals.
O uso de whey protein no manejo da síndrome consumptiva em pacientes HIV+
Authors: Naidu Soujanya 
Published: August 2018

ResumoO presente estudo teve como objetivo analisar a literatura científica disponível sobre a utilização do whey protein (WP) no tratamento da síndrome consumptiva do HIV. Bases de dados completas da PubMed/Medline, Cochrane Central Register of Controlled Trials (CENTRAL, na sigla em inglês), Scielo, ScienceDirect, EuropePubMedCentral, LILACS (BIREME) e BVSalud foram avaliadas, e buscas foram realizadas utilizando combinações entre os seguintes termos: whey protein, síndrome consumptiva, HIV e massa muscular, em inglês, português e espanhol. Três artigos foram identificados para análise; um artigo foi publicado na revista AIDS, um no BMJ, e o terceiro no American Journal of Clinical Nutrition. As três pesquisas foram quantitativas (100%), com um total de 407 participantes (média de participantes = 135,7). Os voluntários de estudo foram, em sua maioria, do sexo feminino (60,7% do total), e não eram portadores de outras doenças crônicas causadoras de consumo proteico, nem usuários de tratamentos de efeito anabólico. Os ensaios foram conduzidos em dois países diferentes, Estados Unidos (n = 2) e Etiópia (n = 1). Um estudo avaliou os efeitos de WP isoladamente, um comparou os efeitos do WP com os do exercício físico, isoladamente, e com uma associação entre WP e exercício, e o terceiro comparou WP à proteína da soja. As principais variáveis investigadas foram peso corporal (n = 3), massa celular corpórea (n = 2), massa livre de gordura ou massa magra (n = 3), massa de gordura (n = 2), e força muscular (n = 2). Dois estudos ainda avaliaram alguns parâmetros imunológicos, como CD4+ (n = 2) e carga viral (n = 1). Os estudos demonstraram que o WP pode levar a ganho de peso, mas não possui efeito significativo sobre massa muscular na síndrome consumptiva do HIV.
The overheating effects in germanium quantum well with two subbands occupied
Authors: Berkutov I. B. , Andrievskii V. V. , Kolesnichenko Yu. A. , Komnik Yu. F. , Mironov O. A. 
Published: August 2018

The charge carrier overheating effect was studied in the p-type Si0.4Ge0.6/Ge/Si0.4Ge0.6 heterostructure with two subband occupy. The temperature dependences of hole-phonon relaxation time τh-ph sat weak magnetic fields demonstrated transition of the 2D system from regime of “partial inelasticity” characterized by dependence τh-ph−1 ∝ T2 to regime of small-angle scattering, described by dependence τh-ph−1 ∝ T5 with temperature increase. But in higher magnetic fields the dependence τh-ph−1 ∝ T3 manifests itself on dependences τh-ph(Th-ph). The possible explanations of such dependences are discussed.
PACS: 72.15.Lh Relaxation times and mean free path; 72.20. My Galvanomagnetic and other magnetotransport effects; 72.20. −i Conductivity phenomena in semiconductors and insulators.
Evaluation of reference genes for RT-qPCR analysis in wild and cultivated Cannabis
Authors: Guo Rong , Guo Hongyan , Zhang Qingying , Guo Mengbi , Xu Yanping , Zeng Min , Lv Pin , Chen Xuan , Yang Ming 
Published: August 2018

ABSTRACT
RT-qPCR has been widely used for gene expression analysis in recent years. The accuracy of this technique largely depends on the selection of suitable reference genes. In order to facilitate gene expression analysis in wild and cultivated Cannabis, the expression stability of seven candidate reference genes (ACT2, 18S rRNA, GAPDH, UBQ, TUB, PP2A and EF1α) were assessed in leaves samples of different development stages and different organs of both wild and cultivated Cannabis in the present study. Their expression stabilities were evaluated through three software packages (GeNorm, Normfinder and Bestkeeper). Results showed that UBQ and EF1α were the highly ranked genes in different leaves samples, and PP2A was the most stable reference gene in different organs, while GAPDH was the least stable one. And the validation of the reference genes selected was further confirmed by the expression patterns of MDS and OLS.
A novel porous Mo3N2/MoO3 hybrid nanobelts as supercapacitor electrode material
Authors: Yuan Yao , Li Xing-Ru , Zhang Xuyang , Wang Jiacheng , Zhou Yao , Lin Cheng-Te , Lin T.-W. , Yang M 
Published: August 2018

Abstract
This article is withdrawn as it is a duplicate of https://doi.org/10.1088/2399-1984/aad9b8.
Incidence and prognostic factors of ataxia in children with posterior fossa tumors
Authors: Hartley Helen , Pizer Barry , Lane Steven , Sneade Christine , Williams Rebecca , Mallucci Conor , Bunn Lisa , Kumar Ram 
Published: August 2018

AbstractBackgroundThere is minimal literature specific to motor outcomes in children with posterior fossa tumors (PFTs) despite ataxia being a significant problem in this group. This study aims to report children’s physical outcomes following management of PFT and determine which factors affect severity of ataxia and functional limitations.MethodsForty-two children aged between 5 and 17 and between 1 and 4 years following surgery for PFT were assessed using the Scale for the Assessment and Rating of Ataxia (SARA), the Brief Ataxia Rating Scale (BARS), and the mobility Pediatric Evaluation of Disability Inventory (PEDI) subscale to determine prevalence and severity of ataxia and a measure of physical function. Analysis was undertaken comparing impact of tumor location, tumor histology, adjuvant treatment, age at diagnosis, presence of preoperative ataxia, and presence of cerebellar mutism syndrome (CMS) on ataxia and physical function scores.ResultsSeventy-one percent of children demonstrated a SARA and BARS score greater than 2. A total of 48% of children had a PEDI-m score greater than 90. There was no correlation between age at diagnosis or preoperative ataxia and assessment scores. There was a significant difference in SARA/BARS and PEDI-mobility scores depending on tumor histology, tumor location, and presence of CMS.ConclusionsA high proportion of children (>1 year) following surgery for PFT continue to present with ataxia. Higher ataxia and lower physical function scores were demonstrated in children with medulloblastoma and midline tumors and those diagnosed with CMS. The high prevalence of ataxia demonstrates the need for further research regarding rehabilitation management in this population.
MicroRNA‐766 promotes cancer progression by targeting NR3C2 in hepatocellular carcinoma
Authors: Yang Chao , Ma Xiang , Guan Ge , Liu Huan , Yang Yuling , Niu Qinghui , Wu Zehua , Jiang Yueping , Bian Cheng , Zang Yunjin , Zhuang Likun 
Published: August 2018

ABSTRACTMicroRNAs (miRNAs) have been reported to play important roles in tumor progression of various cancers. However, the clinical significance and biologic function of miR‐766 in hepatocellular carcinoma (HCC) remain unknown. In this study, we investigated the roles of miR‐766 in HCC progression using HCC cell lines and a xenograft mouse model. miR‐766 expression in tumor tissues and adjacent nontumorous liver tissues of patients with HCC was evaluated by quantitative RT‐PCR. Our results showed that miR‐766 promoted proliferation and metastasis of HCC cells in vitro and in vivo and that NR3C2 was a direct target of miR‐766 and involved in miR‐766–mediated proliferation and metastasis of HCC cells. We also found that miR‐766 affected the β‐catenin signaling pathway by targeting NR3C2. Furthermore, miR‐766 was significantly up‐regulated in HCC tissues and was correlated with the prognosis of patients with liver cancer. Taken together, our results show that miR‐766 affects HCC progression by modulating NR3C2 expression and is a possible new therapeutic target for patients with HCC.—Yang, C., Ma, X., Guan, G., Liu, H., Yang, Y., Niu, Q., Wu, Z., Jiang, Y., Bian, C., Zang, Y., Zhuang, L. MicroRNA‐766 promotes cancer progression by targeting NR3C2 in hepatocellular carcinoma. FASEB J. 33, 1456–1467 (2019). www.fasebj.org
Effect of Intrathecal Bupivacaine Dose on the Success of External Cephalic Version for Breech Presentation: A Prospective, Randomized, Blinded Clinical Trial
Authors: Chalifoux L.A. , Bauchat J.R. , Higgins N. , Toledo P. , Peralta F.M. , Farrer J. , Gerber S.E. , McCarthy R.J. , Sullivan J.T. 
Published: August 2018

(Anesthesiology 2017;127:625–632)
Increased rate of cesarean delivery without measurable improvements in maternal or neonatal outcomes is a major public health problem. Breech presentation is a major contributor to the incidence of cesarean delivery and can be prevented by external cephalic version (ECV). Neuraxial blockade for ECV improves maternal satisfaction and procedural success and decreases maternal pain. Meta-analysis of randomized controlled trials suggests that administering higher doses of local anesthetic (LA) for neuraxial block leads to increased ECV success, although the protocol for providing neuraxial blockade for this procedure has not yet been standardized.
Physical Activity and Preterm Birth: Risk Factor or Benefit?
Authors: Armson B.A. 
Published: August 2018

(BJOG 2017;124:1827)
Exercise during pregnancy has been discouraged in the past, for fear that it may contribute to preterm labor. While physically demanding work, including heavy lifting, physical exertion and prolonged standing, has been associated with an increased risk of preterm birth, it has been recently suggested that exercise during pregnancy may reduce the risk of preterm birth. The safety and effectiveness of exercise preventing preterm birth is still controversial.