bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial and ethnic differences in the association between parent‐oriented perfectionism and disordered eating in college women
Authors: Goel Neha J. , Burnette C. Blair , Mazzeo Suzanne E. 
Published: October 2019

AbstractObjectiveThis study examined the associations between parent‐oriented dimensions of perfectionism (parental expectations [PE] and parental criticism [PC]) and eating disorder (ED) symptomatology across racial/ethnic groups. It was hypothesized that parent‐oriented perfectionism would be positively associated with ED symptomatology for White and Asian American women.MethodUndergraduate women (N = 1,173) completed questionnaires assessing perfectionism, EDs, and demographics. One‐way analyses of variance tested differences in PE and PC across racial/ethnic groups; post‐hoc Tukey tests probed significant differences. Multiple linear regressions assessed associations between parent‐oriented perfectionism and ED symptomatology. Hurdle models tested the association between PE and PC and the frequency and odds of endorsing ED symptomatology.ResultsThere were significant group differences in PE and PC. PE was positively linked with various ED symptoms in Latina, Asian American, and multiracial women, and was negatively related to purging in multiracial women. PC was positively associated with body dissatisfaction in White, Black, and multiracial women, but displayed differential associations with ED symptomatology in all racial/ethnic groups.DiscussionLevels of parent‐oriented dimensions of perfectionism, and their relations to ED symptomatology, might vary across racial/ethnic groups. PE, in particular, is both more elevated, and more strongly linked to eating pathology in Asian American women, whereas PC appears to be especially relevant to ED symptoms in Black women. Findings underscore the importance of considering the role of culture in ED symptomatology. Clinicians and researchers might consider incorporating assessments of parent‐oriented perfectionism into their practice.
Response of antioxidant system to postharvest ozone treatment in ‘Soreli’ kiwifruit
Authors: Goffi Valentina , Magri Anna , Botondi Rinaldo , Petriccione Milena 
Published: October 2019

AbstractBACKGROUNDAmong the challenges for postharvest researchers is that of understanding the physiological and biochemical pathways associated with postharvest fruit decay. Fruit senescence directly affects sensorial and nutritional quality during postharvest life. It has been clarified that reactive oxygen species and oxidative damage are responsible for fruit senescence. Some cultivars of yellow‐fleshed kiwifruit can be stored for a short period compared with green‐fleshed kiwifruit. Postharvest performance is affected by the physiological state of the fruit at harvest, associated with its postharvest management. Among several postharvest applications, ozone treatment is considered as a cost‐effective and eco‐friendly food‐processing technology to preserve the fruits' quality during cold storage. In this study, we investigated the influence of ozone, after gradual cooling treatment, on the antioxidant defense system in Actinidia chinensis, ‘Soreli’.RESULTSBioactive compound content decreased during cold storage, and ozone treatment enhanced the activities of superoxide dismutase and catalase during cold storage. This treatment preserved membrane integrity by inhibiting lipoxygenase activity and malondialdehyde accumulation. A multivariate statistical approach, using principal component analysis, provided the global response to the effect of ozone postharvest treatment during cold storage in kiwifruit ‘Soreli’.CONCLUSIONOzone treatment improves the efficiency of antioxidative system and storability of ‘Soreli’ kiwifruits. © 2019 Society of Chemical Industry
Metformin Effects on FOXP3+ and CD8+ T Cell Infiltrates of Head and Neck Squamous Cell Carcinoma
Authors: Amin Dev , Richa Tony , Mollaee Mehri , Zhan Tingting , Tassone Patrick , Johnson Jennifer , Luginbuhl Adam , Cognetti David , Martinez‐Outschoorn Ubaldo , Stapp Robert , Solomides Charalambos , Rodeck Ulrich , Curry Joseph 
Published: October 2019

ObjectivesAlterations of cellular metabolism have been implicated in immune dysfunction in the tumor microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC). Metformin has recently emerged as a candidate of interest for combination with immunotherapy in HNSCC. This study investigated the effect of metformin on immune cell infiltrates of HNSCC.MethodsRetrospective analysis of T cell infiltrates in primary tumor specimens from patients enrolled in a clinical window of opportunity trial of presurgical metformin. Metformin was titrated to a standard diabetic dose (2000 mg/day) for a minimum of 9 days (mean 13.6 days) prior to surgical resection. Pre and posttreatment surgical specimens from 36 patients (16 HPV+, 20 HPV−) were comparatively analyzed. FOXP3+ and CD8+ immune cell infiltrates in the tumor and peritumoral stroma of pre and posttreatment HNSCC specimens were quantified by digital image analysis using Visiopharm software.ResultsMetformin treatment was associated with a 41.4% decrease in FOXP3+ T cells in intratumor regions of interest (P = .004) and a 66.5% increase in stromal CD8+ T cells at the leading edge of the tumor (P = .021) when compared to pretreatment biopsies. This was reflected in increased CD8+/FOXP3+ cell ratios within the tumor (P < .001) and stromal compartments (P < .001). The effects of metformin occurred independently of HPV status.ConclusionMetformin treatment may favorably alter the immune TME in HNSCC independent of HPV status.Level of Evidence1b. This study is most accurately described as a non‐randomized controlled trial and therefore may reflect a level of evidence below 1b but above 2a from the provided “levels of evidence” chart. Laryngoscope, 130:E490–E498, 2020
Deep learning–based MR‐to‐CT synthesis: The influence of varying gradient echo–based MR images as input channels
Authors: Florkow Mateusz C. , Zijlstra Frank , Willemsen Koen , Maspero Matteo , van den Berg Cornelis A. T. , Kerkmeijer Linda G. W. , Castelein René M. , Weinans Harrie , Viergever Max A. , van Stralen Marijn , Seevinck Peter R. 
Published: October 2019

PurposeTo study the influence of gradient echo–based contrasts as input channels to a 3D patch‐based neural network trained for synthetic CT (sCT) generation in canine and human populations.MethodsMagnetic resonance images and CT scans of human and canine pelvic regions were acquired and paired using nonrigid registration. Magnitude MR images and Dixon reconstructed water, fat, in‐phase and opposed‐phase images were obtained from a single T1‐weighted multi‐echo gradient‐echo acquisition. From this set, 6 input configurations were defined, each containing 1 to 4 MR images regarded as input channels. For each configuration, a UNet‐derived deep learning model was trained for synthetic CT generation. Reconstructed Hounsfield unit maps were evaluated with peak SNR, mean absolute error, and mean error. Dice similarity coefficient and surface distance maps assessed the geometric fidelity of bones. Repeatability was estimated by replicating the training up to 10 times.ResultsSeventeen canines and 23 human subjects were included in the study. Performance and repeatability of single‐channel models were dependent on the TE‐related water–fat interference with variations of up to 17% in mean absolute error, and variations of up to 28% specifically in bones. Repeatability, Dice similarity coefficient, and mean absolute error were statistically significantly better in multichannel models with mean absolute error ranging from 33 to 40 Hounsfield units in humans and from 35 to 47 Hounsfield units in canines.ConclusionSignificant differences in performance and robustness of deep learning models for synthetic CT generation were observed depending on the input. In‐phase images outperformed opposed‐phase images, and Dixon reconstructed multichannel inputs outperformed single‐channel inputs.
Insights into tissue microstructure using a double diffusion encoding sequence on a clinical scanner: Validation and application to experimental tumor models
Authors: Duchêne Gaëtan , Abarca‐Quinones Jorge , Leclercq Isabelle , Duprez Thierry , Peeters Frank 
Published: October 2019

PurposeTo present a double diffusion encoding MRI sequence on a clinical scanner to analyze micro‐structure and micro‐vasculature of tumors.MethodsThe sequence was tested on phantoms, asparaguses, and 2 tumors allografts in a rodent. Results were analyzed using an adapted VERDICT model to estimate microstructural parameters. The technical feasibility of the sequence on a 3T clinical system was assessed on a water phantom. The accuracy of cell size estimation was assessed on asparaguses by comparison with light microscopy. Cell size estimations were also validated when limiting relative angles of diffusion encodings to 0 and 180°. Sensitivities to restricted diffusion and incoherent flow from the vasculature were investigated in experimental tumor models. Values of microstructural parameters in viable and decaying tumor tissue were compared with those obtained from histological analysis.ResultsMeasurements on the water phantom revealed no significant sequence artifacts and accurate apparent diffusion coefficient values within a 4% relative error. In asparaguses, quartiles and medians of pore size distributions typically deviated less than 6% from light microscopy regardless of whether the full or reduced set of relative angles was used. Signal analyses in tumors showed mixed effects of both blood flow and diffusion restriction. Microstructural parameter estimations in tumors were consistent with histology and allowed clear and histology‐proven distinctions between decaying and viable tumor tissue.ConclusionsDouble diffusion encoding with clinical gradients and scan times allows characterization of restricted diffusion and micro‐circulation flow in tumors. Our estimated microstructural parameters are promising for further investigations in assessing microstructural evolutions in tumors.
Combining aquatic physiotherapy with usual care physiotherapy for people with neurological conditions: A systematic review
Authors: Moritz Tamara A. , Snowdon David A. , Peiris Casey L. 
Published: October 2019

AbstractObjectiveThe objective of this review was to determine whether the combination of aquatic physiotherapy with usual care and results in greater improvements in activity limitations and neurological‐related impairments in individuals with neurological conditions than usual care physiotherapy alone.MethodsA systematic review of controlled trials was utilized to compare usual care physiotherapy with usual care physiotherapy combined with aquatic physiotherapy for adults with any neurological condition. Standardized mean differences and 95% confidence intervals were calculated from postintervention means and standard deviations.ResultsTen trials with a total of 490 participants met the inclusion criteria. Of the included trials, combined aquatic and usual care physiotherapy was evaluated in people with stroke in eight trials and in people with Parkinson's disease in two trials. Trial and outcome heterogeneity prevented the completion of meta‐analyses. Data from five trials (n = 259) in people with stroke suggest that aquatic physiotherapy improves measures of balance, walking, mobility, and activities of daily living. No significant differences were detected in measures of activity limitation for people with Parkinson's disease nor measures of impairment for people with stroke or Parkinson's disease.ConclusionThis review provides preliminary evidence that the combination of aquatic physiotherapy with usual care physiotherapy may improve activity limitations in people with stroke. This review found no evidence to support the combination of aquatic physiotherapy with usual care physiotherapy to improve activity limitations in Parkinson's disease or other neurological populations. These results should be interpreted with caution due to the mixed quality of the included trials.
Doping Strategy for Efficient and Stable Triple Cation Hybrid Perovskite Solar Cells and Module Based on Poly(3‐hexylthiophene) Hole Transport Layer
Authors: Yaghoobi Nia Narges , Lamanna Enrico , Zendehdel Mahmoud , Palma Alessandro L. , Zurlo Francesca , Castriotta Luigi Angelo , Di Carlo Aldo 
Published: October 2019

AbstractAs the hole transport layer (HTL) for perovskite solar cells (PSCs), poly(3‐hexylthiophene) (P3HT) has been attracting great interest due to its low‐cost, thermal stability, oxygen impermeability, and strong hydrophobicity. In this work, a new doping strategy is developed for P3HT as the HTL in triple‐cation/double‐halide ((FA1−x−yMAxCsy)Pb(I1−xBrx)3) mesoscopic PSCs. Photovoltaic performance and stability of solar cells show remarkable enhancement using a composition of three dopants Li‐TFSI, TBP, and Co(III)‐TFSI reaching power conversion efficiencies of 19.25% on 0.1 cm2 active area, 16.29% on 1 cm2 active area, and 13.3% on a 43 cm2 active area module without using any additional absorber layer or any interlayer at the PSK/P3HT interface. The results illustrate the positive effect of a cobalt dopant on the band structure of perovskite/P3HT interfaces leading to improved hole extraction and a decrease of trap‐assisted recombination. Non‐encapsulated large area devices show promising air stability through keeping more than 80% of initial efficiency after 1500 h in atmospheric conditions (relative humidity ≈ 60%, r.t.), whereas encapsulated devices show more than >500 h at 85 °C thermal stability (>80%) and 100 h stability against continuous light soaking (>90%). The boosted efficiency and the improved stability make P3HT a good candidate for low‐cost large‐scale PSCs.
Method to quantify the in vivo skin penetration of topically applied materials based on confocal Raman spectroscopy
Authors: Caspers Peter J. , Nico Claudio , Bakker Schut Tom C. , de Sterke Johanna , Pudney Paul D. A. , Curto Patricia R. , Illand Abigail , Puppels Gerwin J. 
Published: October 2019

AbstractThis article describes a unique noninvasive capability to determine the concentration (in mg/cm3) and total amount of topically applied materials in the skin (in μg/cm2 of skin surface). It is based on in vivo confocal Raman spectroscopy. A theoretical derivation is given of a general method to calculate a concentration ratio from a Raman spectrum of a material in a medium, which can be a solvent or other matrix, such as the skin. A practical implementation of the method is then presented along with a clarification of the assumptions used and applied to a quantitative analysis of the in vivo skin penetration of trans‐retinol and propylene glycol (PG). A comparison was made between the concentrations profiles of retinol and PG found in the skin and the concentrations of retinol and PG that had been applied to the skin. Determination of the amount of these materials in the skin at different timepoints after topical application also enabled a straightforward calculation of the flux of materials into the skin (in μg cm−2 h).
Taking services to foreign markets: A taxonomy of Brazilian service firms
Authors: da Silva Gilberto Figueira , da Rocha Angela , da Silva Jorge Ferreira 
Published: October 2019

AbstractThis study develops a taxonomy of international service firms from an emerging market, Brazil, and assesses whether there are significant differences in international performance between the groups. After an extensive literature review, a survey was carried out with a sample of international service firms located in an emerging economy, Brazil. Using as a departure point two theoretical perspectives, the internationalization process theory and industrial organization theory, in addition to service dimensions extracted from the empirical service management literature, the study identifies four groups—large traditionals, generalist neophytes, solitary traditionals, and daring differentiators—based on firm characteristics, international services delivered, internationalization process characteristics, and international strategies adopted. The findings suggest that there are significant differences in performance between the groups.
Intercultural Music Teacher Education in Israel: Reimagining Religious Segregation Through Culturally Responsive Teaching
Authors: Ehrlich Amira , Badarne Belal 
Published: October 2019

AbstractThis chapter is a result of a rare effort of interreligious dialogue between two colleagues in Israeli music teacher education – an Orthodox Jew and a devout Muslim. In this act of collegial sharing, intercultural conversation is used as an instrument for research. The documented effort to communicate respective culturally grounded perspectives to one another illuminates taken-for-granted norms and habits and expands respective understandings of cultural assumptions that currently underlie structures of religious segregation in Israeli music teacher education. Working to reimagine such structures, the authors question the possibility of inter-culturalism in the context of segregation. Tracing the constraints of cultural diversity further, considering policy and music teacher education, the authors re-imagine socio-religious segregation in Israeli music teacher education as an opportunity for culturally responsive teaching. The analysis and the envisioning are grounded in the experiences of the two authors as lecturers in two specialized segregated programs of music teacher education geared towards Arabic speaking populations and the Jewish Ultraorthodox community. Conclusions aspire towards cultural specificity within each community as a platform for future intercultural sharing that the authors believe can enrich Israeli society at large.
Bridging Musical Worlds: Musical Collaboration Between Student Musician-Educators and South Sudanese Australian Youth
Authors: Marsh Kathryn , Ingram Catherine , Dieckmann Samantha 
Published: October 2019

AbstractThis chapter reports results of an innovative contemporary model of applied urban ethnomusicological research investigating the effects of collaborative musical engagement between students from the Sydney Conservatorium of Music (SCM) and South Sudanese Australian youth in the culturally diverse metropolis of Sydney, Australia. TheBridging Musical Worldsproject was conducted in 2016 during a period of extraordinary global migration. In Australia, children and young people of South Sudanese heritage occupy a prominent place in emerging communities in many large urban areas but are often subject to discriminatory discourse. The project enabled SCM music education students to engage in reciprocal teaching and learning opportunities relating to South Sudanese music and culture and globalised popular music. In this chapter we outline the major outcomes of the project, including social inclusion through collaborative participatory music making, and explore the impact of these musical activities on the development of cultural competence and intercultural understanding for tertiary students.
Microbial production of O-methylated flavanones from methylated phenylpropanoic acids in engineered Escherichia coli
Authors: Cui Heqing , Song Myoung Chong , Lee Ji Young , Yoon Yeo Joon 
Published: October 2019

Abstract
Methylated flavonoids possess improved bioactivities compared to their unmethylated counterparts. In this study, for the efficient production of O-methylated flavonoids from simple methylated phenylpropanoic acids, a recombinant Escherichia coli strain expressing 4-coumarate:coenzyme A ligase (4CL) from Oryza sativa and chalcone synthase (CHS) from Hordeum vulgare was constructed; this strain produced significant amount of homoeriodictyol (~ 52 mg/L) as well as a few amount of hesperetin (0.4 mg/L), respectively, from ferulic acid and 4-methylcaffeic acid. This demonstrates, for the first time, that the scarce but valuable methylated flavanones can be successfully produced from methylated phenylpropanoic acids in a microbial host via an artificial biosynthetic pathway consisting of 4CL and CHS that can accept O-methylated precursors.
Beneficial mutations for carotenoid production identified from laboratory-evolvedSaccharomyces cerevisiae
Authors: Godara Avinash , Rodriguez Maria Alejandra Gomez , Weatherston Joshua D , Peabody George L , Wu Hung-Jen , Kao Katy C 
Published: October 2019

AbstractAdaptive laboratory evolution (ALE) is a powerful tool used to increase strain fitness in the presence of environmental stressors. If production and strain fitness can be coupled, ALE can be used to increase product formation. In earlier work, carotenoids hyperproducing mutants were obtained using an ALE strategy. Here, de novo mutations were identified in hyperproducers, and reconstructed mutants were explored to determine the exact impact of each mutation on production and tolerance. A single mutation in YMRCTy1-3 conferred increased carotenoid production, and when combined with other beneficial mutations led to further increased β-carotene production. Findings also suggest that the ALE strategy selected for mutations that confer increased carotenoid production as primary phenotype. Raman spectroscopy analysis and total lipid quantification revealed positive correlation between increased lipid content and increased β-carotene production. Finally, we demonstrated that the best combinations of mutations identified for β-carotene production were also beneficial for production of lycopene.
Efficacy of preemptive analgesia versus postoperative analgesia of celecoxib on postoperative pain, patients’ global assessment and hip function recovery in femoroacetabular impingement patients underwent hip arthroscopy surgery
Authors: Zhu Xiaoping 
Published: October 2019

Abstract
We aimed to investigate the efficacy of preemptive analgesia of celecoxib on postoperative pain, patients’ global assessment (PGA) and hip function recovery compared to postoperative analgesia of celecoxib in femoroacetabular impingement (FAI) patients who underwent hip arthroscopy surgery (HAS). The 100 FAI patients underwent HAS were randomly allocated to preemptive analgesia group (N = 50) or postoperative analgesia group (N = 50) as a 1:1 ratio for 3 months. Pain visual analog scale (VAS) score, PGA score, rescue-use pethidine consumption and Harris hip score were assessed. Compared to postoperative analgesia group, pain VAS score decreased on day 1 (P = 0.036), day 2 (P = 0.046) and day 3 (P = 0.046), while was similar prior to operation (P = 0.587), on day 7 (P = 0.398), at month 1 (P = 0.461) and month 3 (P = 0.805) in preemptive analgesia group. Besides, rescue-use pethidine consumption was decreased in preemptive analgesia group than postoperative analgesia group within 3 days (P = 0.016) and within 7 days (P = 0.033) post-operation. For PGA score, it reduced on day 2 (P = 0.030) and day 3 (P = 0.048), while was similar prior to operation (P = 0.699), on day 1 (P = 0.699), day 7 (P = 0.224), at month 1 (P = 0.640) and month 3 (P = 0.400) in preemptive analgesia group than postoperative analgesia group. For Harris hip score, it was similar prior to operation (P = 0.372), on day 7 (P = 0.366), at month 1 (P = 0.466) and month 3 (P = 0.658) between the two groups. In conclusion, preemptive analgesia of celecoxib decreases short-term postoperative pain and PGA, but without effect on long-term hip function recovery than postoperative analgesia of celecoxib in FAI patients who underwent HAS.