bluuebunny/crossref_metadata_2025_split huggingface dataset:
A call for inclusive research, policies, and leadership to close the global women’s health gap
Authors: Aninye Irene O. 
Published: November 2024

AbstractWomen comprise approximately half of the world’s population, yet they are often underrepresented and inadequately considered in medical and public health research and in health care delivery in the United States and around the world. Elucidating sex and gender differences in disease and fundamental hormonal drivers of women’s health is instrumental to informing our overall understanding of human health and improving women’s health outcomes across the lifespan. The Society for Women’s Health Research and ECH Alliance–The Global Health Connector hosted a women’s health program as part of the United Nations 79th General Assembly Science Summit. Here, I briefly describe the basis for this convening to address global gender health gaps and reflect on the event’s presentations and discussions to recognize and better integrate women’s unique health needs in the sustainable development goals.
Restoring grazing agroecosystems in Mediterranean less favoured areas for resilience and productivity: experts opinion
Authors: Poulopoulou Ioanna , Hadjipavlou Georgia , Gamper Hannes , Lazereg Messaoud , Ocak Yetişgin Sezen , Mohamed Alaa , Gauly Matthias , Gaki Dimitra , Goussios Dimitris , Faraslis Ioannis , Tsiokos Dimitrios , Santeramo Fabio , Marques-dos-Santos Cláudia , Rosati Andrea , Bebeli Penelope J. , Khalil Wagdy K. B. , Hadjigeorgiou Ioannis 
Published: November 2024

AbstractMediterranean agroecosystems are under increasing pressures by extreme weather events, which together with poor livestock grazing management bring the already degraded lands closer to desertification. To address these challenges, we develop a decision support manual for sustainable management of degraded lands based on local plant and animal resources. We present a conceptual approach to quantify the quality attributes of current pasture-based livestock and mixed farming systems to increase their added value. Most approaches focus on lowland areas, we propose building a system to assess and quantify the quality and management of grazing lands as well as the small ruminant farming practices in Less Favoured Areas (LFAs) areas of the Mediterranean. The interventions have been proposed by 17 researchers from different disciplines ranging from animal science and animal husbandry, nutrition and genetics, pasture management, plant breeding and soil science to regional development and environmental science and agricultural economics. They are based on technical and socio-economic information, to foster the development of business models towards sustainable management of regenerative grazing. These models are also expected to be used as evidence for motivating farmers and stakeholders in reinforcing grazing as a practice that, when properly used and implemented using local knowledge, reduces land degradation and contributes to the conservation of the local resources. The economic analysis showing the costs and benefits of the applied systems is important to foster the integration and implementation of the recommended schemes and leads to more efficient planning through better decision making. The proposed interventions are designed to stimulate farmers to learn or rediscover grazing techniques, and to stimulate a re-think of priorities on the multi-faceted contribution of grazing agro-ecosystems, among others, on soil health, land degradation, sustainable grazing management and population conservation in LFAs, acknowledging the importance of pastureland regeneration. In the long term the introduction of the decision support manual and the business model will benefit the quality and management of grazing agroecosystems. Furthermore, it is essential to adjust the agricultural policies to implenent the proposed measures.
Use of the “quick brown fox jumps over the lazy dog” pangram in academic papers
Authors: Teixeira da Silva Jaime A. 
Published: November 2024

AbstractIn the English language, when a sentence contains all letters of the alphabet, such as “The/A quick brown fox jumps over the lazy dog”, this is known as a pangram. Curiously, despite its odd meaning, this fox-dog pangram has found practical usage in some applications, mainly in text typography related to computer graphics, in linguistics, as a writing tutorial, or for testing computer keyboards. Even more curiously, it has been detected as a residual of template text in some academic papers. This unique linguistic curiosity was examined by screening Scopus and Web of Science, as well as Google Scholar from 2019–2023, to appreciate its practical use, as well as to assess whether there were any cases of residual template text, the main target of this exercise. In the latter case, this letter advocates for the removal of this residual text, in the form of a literary correction.
Vaccination as an element of health security management - analysis of factors of patient attitudes towards COVID-19 preventive vaccinations based on the opinions of healthcare experts
Authors: Karczmarz Sabina , Owczarczyk Anna , Żuk Paweł , Średziński Leszek , Prusaczyk Artur , Bogdan Magdalena 
Published: November 2024

Background: Preventive vaccinations play a significant role in reducing the spread of infectious diseases. They mitigate the course of infectious diseases and limit the occurrence thereof. Thus, they allow maintaining the health security of citizens and are one of the activities that allow for effective population health management. However, even though vaccinations bring significant benefits to the population as a whole, the attitudes of individuals to them raise a number of controversies.
Objective: The aim of the study was to analyze the characteristics and factors of patient attitudes towards COVID-19 preventive vaccinations based on the opinions of healthcare experts. The study was carried out in the framework of a project "The interdependence of lifestyle and attitudes towards COVID-19 preventive vaccinations", which finished in June 2023.
Method: The research method was an in-depth telephone interview with experts who had previously studied the research problem and the results of quantitative research, and expressed individual opinions on the factors of patient attitudes towards COVID-19 vaccinations. The experts indicated various factors which, in their opinion, can influence patient willingness to be vaccinated against COVID-19. In the research process, four main factors were found: patient social environment and patient experience; patient knowledge and awareness, social impact (message of medical authorities and political decision makers), balance of benefits and risks.
Results: The results obtained in the study and the conclusions drawn show the need for further, in-depth research in patient attitudes towards preventive vaccinations, not only COVID-19 vaccinations.
The impact of concomitant meniscal surgery on the clinical outcomes of anterior cruciate ligament reconstruction
Authors: Gabr Ayman , Fontalis Andreas , Robinson James , Hage William , O'Leary Sean , Spalding Tim , Haddad Fares S. 
Published: November 2024

AimsThe aim of this study was to compare patient-reported outcomes (PROMs) following isolated anterior cruciate ligament reconstruction (ACLR), with those following ACLR and concomitant meniscal resection or repair.MethodsWe reviewed prospectively collected data from the UK National Ligament Registry for patients who underwent primary ACLR between January 2013 and December 2022. Patients were categorized into five groups: isolated ACLR, ACLR with medial meniscus (MM) repair, ACLR with MM resection, ACLR with lateral meniscus (LM) repair, and ACLR with LM resection. Linear regression analysis, with isolated ACLR as the reference, was performed after adjusting for confounders.ResultsFrom 14,895 ACLR patients, 4,400 had two- or five-year Knee injury and Osteoarthritis Outcome Scores (KOOS) available. At two years postoperatively, the MM repair group demonstrated inferior scores in KOOS pain (β = −3.63, p < 0.001), symptoms (β = − 4.88, p < 0.001), ADL (β = − 2.43, p = 0.002), sport and recreation (β = − 5.23, p < 0.001), quality of life (QoL) (β = − 5.73, p < 0.001), and International Knee Documentation Committee (β = − 4.1, p < 0.001) compared with the isolated ACLR group. The LM repair group was associated with worse KOOS sports and recreation scores at two years (β = − 4.264, p < 0.001). At five years, PROMs were comparable between the groups. At five years, PROMs were comparable between the groups. Participants undergoing ACLR surgery within 12 weeks from index injury demonstrated superior PROMs at two and five years.ConclusionOur study showed that MM repair, and to a lesser extent LM repairs in combination with ACLR, were associated with inferior patient-reported outcome measures (PROMs) compared to isolated ACLR at two years postoperatively, while meniscal resection groups exhibited comparable outcomes. However, by five years postoperation, no significant differences in PROMs were evident. Further longer-term, cross-sectional studies are warranted to investigate the outcomes of ACLR and concomitant meniscal surgery.
Diagnostic accuracy of a smartphone-based device (VistaView) for detection of diabetic retinopathy: A prospective study
Authors: Shahzad Rida , Mehmood Arshad , Shabbir Danish , Siddiqui M. A. Rehman 
Published: November 2024

Background
Diabetic retinopathy (DR) is a leading cause of blindness globally. The gold standard for DR screening is stereoscopic colour fundus photography with tabletop cameras. VistaView is a novel smartphone-based retinal camera which offers mydriatic retinal imaging. This study compares the diagnostic accuracy of the smartphone-based VistaView camera compared to a traditional desk mounted fundus camera (Triton Topcon). We also compare the agreement between graders for DR screening between VistaView images and Topcon images.

Methodology
This prospective study took place between December 2021 and June 2022 in Pakistan. Consecutive diabetic patients were imaged following mydriasis using both VistaView and Topcon cameras at the same sitting. All images were graded independently by two graders based on the International Classification of Diabetic Retinopathy (ICDR) criteria. Individual grades were assigned for severity of DR and maculopathy in each image. Diagnostic accuracy was calculated using the Topcon camera as the gold standard. Agreement between graders for each device was calculated as intraclass correlation coefficient (ICC) (95% CI) and Cohen’s weighted kappa (k).

Principal findings
A total of 1428 images were available from 371 patients with both cameras. After excluding ungradable images, a total of 1231 images were graded. The sensitivity of VistaView for any DR was 69.9% (95% CI 62.2–76.6%) while the specificity was 92.9% (95% CI 89.9–95.1%), and PPV and NPV were 80.5% (95% CI 73–86.4%) and 88.1% (95% CI 84.5–90.9) respectively. The sensitivity of VistaView for RDR was 69.7% (95% CI 61.7–76.8%) while the specificity was 94.2% (95% CI 91.3–96.1%), and PPV and NPV were 81.5% (95% CI 73.6–87.6%) and 89.4% (95% CI 86–92%) respectively. The sensitivity for detecting maculopathy in VistaView was 71.2% (95% CI 62.8–78.4%), while the specificity was 86.4% (82.6–89.4%). The PPV and NPV of detecting maculopathy were 63% (95% CI 54.9–70.5%) and 90.1% (95% CI 86.8–92.9%) respectively. For VistaView, the ICC of DR grades was 78% (95% CI, 75–82%) between the two graders and that of maculopathy grades was 66% (95% CI, 59–71%). The Cohen’s kappa for retinopathy grades of VistaView images was 0.61 (95% CI, 0.55–0.67, p<0.001), while that for maculopathy grades was 0.49 (95% CI 0.42–0.57, p<0.001). For images from the Topcon desktop camera, the ICC of DR grades was 85% (95% CI, 83–87%), while that of maculopathy grades was 79% (95% CI, 75–82%). The Cohen’s kappa for retinopathy grades of Topcon images was 0.68 (95% CI, 0.63–0.74, p<0.001), while that for maculopathy grades was 0.65 (95% CI, 0.58–0.72, p<0.001).

Conclusion
The VistaView offers moderate diagnostic accuracy for DR screening and may be used as a screening tool in LMIC.
Development of the Ward Nurses’ Perspective-taking of the Staff Receiving Discharged Patients Scale: An observational study of ward nurses
Authors: Tanaka Shingo , Saiki Masatoshi , Takemura Yukie 
Published: November 2024

Introduction
Discharge planning involves coordinating between different care settings. Failed coordination can lead to delayed care at the facilities receiving discharged patients. Nurses who implement discharge planning must consider the circumstances of the staff receiving the discharged patients.

Objective
This study aims to develop a nurses’ perspective-taking scale for measuring the cognitive process of imagining a staff’s situation when receiving discharged patients.

Methods
An online survey was conducted from September to November 2021 with nurses in Japanese acute care hospitals, using a 20-item questionnaire based on interviews and a literature review. Item reduction was conducted based on inter-item correlations, item-total correlations, and exploratory factor analysis. Confirmatory factor analysis was performed. For the exploratory and confirmatory factor analysis, the samples were randomly split in half and tested. Cronbach’s alpha, intraclass correlation coefficients, and correlation coefficients were calculated using both self-developed and pre-existing measures.

Results
The questionnaire was distributed to 1,289 individuals, and 416 valid responses were obtained. Item reduction and exploratory factor analysis resulted in a 10-item scale with two subscales, “imagine-other” (six items), which is imagining the other person’s situation, and “imagine-self” (four items), which is imagining oneself in the other person’s situation. The goodness-of-fit indices were as follows: comparative fit index, 0.95; root mean square error of approximation, 0.08; and standardized root mean squared residual, 0.06. Correlation coefficients with existing scales were 0.38, 0.57, and -0.33. Cronbach’s alpha was 0.89, and the intraclass correlation coefficient was 0.54.

Conclusion
The newly developed scale proved to be reliable, valid, and suitable for use. This scale can measure the degree of perspective-taking by nurses, which can improve collaboration between facilities and the effectiveness of discharge planning.
Elevated plasma progranulin levels in the acute phase are correlated with recovery of left ventricular function in the chronic phase in patients with acute myocardial infarction
Authors: Minatoguchi Shingo , Satake Atsushi , Murase Hirotaka , Yoshizumi Ryo , Komaki Hisaaki , Baba Shinya , Yasuda Shinji , Ojio Shinsuke , Tanaka Toshiki , Okura Hiroyuki , Minatoguchi Shinya 
Published: November 2024

Background
Progranulin is a secreted glycoprotein that regulates inflammation and wound healing. However, plasma progranulin levels in the acute phase and their clinical significance in patients with acute myocardial infarction (AMI) remain to be elucidated.

Objective
We aimed to investigate the relationship between the increase in plasma progranulin levels in the acute phase and the recovery of left ventricular function in the chronic phase in AMI patients.

Method and result
Eighteen AMI patients were followed up for 6 months. Blood samples were collected from the antecubital vein on day 0 (on admission) and day 7 in the acute phase. The control group consisted of patients without significant coronary artery stenosis, as assessed by cardiac catheterization (n = 16). Plasma progranulin levels were measured by enzyme-linked immunosorbent assay. Echocardiography was performed in the acute (within 7 days) and chronic (6 months) phases of AMI to evaluate left ventricular ejection fraction using the modified Simpson’s method. Plasma progranulin levels in the AMI group on day 0 (69.5 ± 24.6 ng/mL) were similar to those in the control group (84.2 ± 47.1 ng/mL). There was a significant increase in progranulin levels in the AMI group on day 7 (104.2 ± 52.0 ng/mL) compared with day 0. The increase in plasma progranulin levels in the acute phase was positively correlated with the increase in left ventricular ejection fraction between the acute and chronic phases. Among various factors, only plasma progranulin levels were favorably correlated with left ventricular functional recovery in the chronic phase.

Conclusion
The increase in plasma progranulin levels in the acute phase may serve as a predictive biomarker and a contributer for the recovery of left ventricular function in the chronic phase in patients with AMI.
Acupuncture for uremic pruritus: A systematic review and meta-analysis protocol
Authors: Gao Ning , Wang Lei , Wang Weiming , Guo Yufeng 
Published: November 2024

Background
Uremic pruritus (UP) or chronic kidney disease-associated pruritus (CKD-aP) is one of the most intractable dermatologic symptom in patients with chronic kidney disease. Several randomized controlled trials (RCTs) have been conducted to investigate the antipruritic effects of acupuncture on UP/CKD-aP and suggested a significant therapeutic effect, while the evidence supporting the application of acupuncture is limited.

Objectives
This study will assess the efficacy and safety of acupuncture for patients with UP/CKD-aP.

Methods
Data Sources: RCTs will be searched in MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, the Chinese Biomedical Literature Database, the China National Knowledge Infrastructure, Wanfang Database, VIP Database, the WHO International Clinical Trials Registry Platform portal and www.ClinicalTrials.gov from inception to 31st August 2024. Study eligibility criteria: RCTs in English and Chinese conducted on UP/CKD-aP patients will be included. Participants: Adult patients diagnosed with UP/CKD-aP will be included. Interventions: All acupuncture interventions in the management of UP/CKD-aP will be included, compared with no treatment, placebo or sham acupuncture, or other treatment agents. Outcome measures: The primary outcome will be the change in the severity of itching evaluated by validated scales. Study appraisal and svnthesis methods: If necessary, a meta-analysis will be performed for the pooled therapeutic effect by Review Manager 5.3, or a qualitative descriptive analysis will be presented. The data will be transformed into the risk ratio (RR) for binary data and the mean difference (MD) or standardized MD for continuous data for analysis.

Results
This review will update evidence of RCTs evaluating acupuncture for UP/CKD-aP.

Limitations
Anticipated challenges contain the methodological and clinical heterogeneity in terms of evaluation tools and acupuncture interventions within included studies.

Conclusion and implications
It will benefit patients and impact health-care decision-making regarding the models of care that are feasible for patients.

Trial registration
PROSPERO CRD42021257001.
Predictors of neonatal hypothermia within six hours of birth and exploring preventive practices among post-natal mothers in Kilimanjaro region: Explanatory sequential mixed method protocol
Authors: Daniel Emmanuel , Seif Saada A. , Millanzi Walter C. 
Published: November 2024

Background
Neonatal hypothermia is a worldwide problem that can lead to a high impact on neonatal health outcomes if appropriate thermal care measures are not implemented. Tackling neonatal hypothermia from the time of delivery with appropriate thermal care measures will increase neonatal survival and decrease complications related to hypothermia.

Objective
The study aims to determine the predictors of neonatal hypothermia within six hours of birth and explore its preventive practices among postnatal mothers.

Methods
This is a mixed-method sequential explanatory study. The first phase will be a quantitative study with a hospital-based analytical cross-sectional design. 325 neonates and their mothers will be randomly selected through a 4-stage sampling technique. The data will be collected using a structured questionnaire, checklist and documentary review. Descriptive and inferential statistics will be used to analyse the data. The second phase will be a descriptive qualitative study involving postnatal mothers who participated in a quantitative study. The data will be collected via in-depth interviews, and thematic analysis will be used to analyse the data. The findings of quantitative and qualitative studies will be triangulated in the discussion.

Discussion
This study will provide a wide understanding of neonatal hypothermia in the region which will help healthcare providers who are caring for neonates to be informed about the current situation, evaluate the care they provide, and find the best way to adhere to thermal care measures. Moreover, the practices of postnatal mothers will be known, which will help to develop tailored interactions to address this problem.
A Delayed Postoperative Anastomotic Submucosal Abscess
Authors: Hu Xiao-Tong , Wang Dong 
Published: November 2024

ABSTRACT
Delayed anastomotic submucosal abscess is a rare complication of rectal tumor resection. A submucosal tumor-like lesion near the anastomotic site was detected in a 57-year-old woman, and pus and sutures were found through spontaneously formed fistulas. Endoscopic ultrasound confirmed the presence of hyperechoic pus flowing out from the fistulas on compression of the lesion. The patient recovered well without surgery. This case indicates that submucosal abscess should be taken into consideration if suspected submucosal tumor-like lesions are detected after rectal surgery. Endoscopic drainage combined with antibiotic treatment may be an effective strategy for limited postoperative anastomotic abscess.
Effect of Trichosanthes cucumerina Methanol Extract on CRP and Fibrinogen Levels in Diabetic Ulcer Rat Models
Authors: Shafriani Nazula Rahma , Astuti Tri Dyah , Amri Shofy Farha Aulia , Permana Riski Aditya , Fridhoriansyah Zuvi , Maharani Intan 
Published: November 2024

Diabetic ulcers can be fatal for people with long-term diabetes. This is caused by the spread of diabetic ulcers and inadequate care for the wound, which can induce an infection and even death. This study aims to determine inflammatory markers, specifically fibrinogen and C-Reactive Protein (CRP), as indicators of healing, particularly in a rat model of diabetic ulcers treated with Trichosanthes cucumerina methanol extract. The methods used were making extracts, measuring blood glucose levels, measuring CRP, and measuring fibrinogen levels in 25 male Wistar rats. Based on the results of glucose and fibrinogen examinations in all groups before treatment and after treatment, it showed a decrease in glucose and fibrinogen levels. Meanwhile, the results of CRP examinations, before and after treatment did not show any differences. The results of statistical analysis showed that there was a significant difference of p<0.05 in pre and post glucose, as well as pre and post fibrinogen.The extract that reduced fibrinogen levels the most was group 3 with 500 mg/KgBW. Meanwhile, CRP levels before and after treatment did not show a decrease.