bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poetree by C. Pignat
Authors: MacLeod Lorisia 
Published: April 2019

Pignat, Caroline. Poetree. Illustrated by François Thisdale, Red Deer Press, 2018.
Caroline Pignat is a two-time Governor General Award winner and it’s easy to see why when one looks at her latest beautiful book. Each page of Poetree is simply delightful with short simple poems complemented by François Thisdale’s excellent illustrations. The illustrations perfectly invoke the feeling of the poem whether it be the frosty cold of a silent winter’s morning or the pure warm delight of a warm summer's day. The short length of the poetry and the everyday-vocabulary chosen by Pignat makes this book accessible to many readers, even those working on their English skills or who are new to poetry.
For educators and librarians, this book would be an excellent addition to a program celebrating poetry. In fact, the style of the short poems and illustrations focusing on daily life could be showcased in the reading of this book and then learners could work on creating their own illustrated poems in the style of Poetree. The combination of eye-catching illustrations with high contrast text will no doubt delight audiences of all ages if used in story times and the overall simplicity of the language would allow newer readers to still engage, making this an excellent addition to classrooms and libraries.
Recommended with Reservations: 3 stars out of 4 Reviewer: Lorisia MacLeod
Lorisia MacLeod is an Instruction Librarian at NorQuest College Library and a proud member of the James Smith Cree Nation. When not working on indigenization or diversity in librarianship, Lorisia enjoys reading almost any variation of Sherlock Holmes, comics, or travelling.
Una Huna?: What Is This? by S. Aglukark
Authors: Quirk Linda 
Published: April 2019

Aglukark, Susan. Una Huna?: What Is This? Illustrated by Amanda Sandland and Danny Christopher, Inhabit Media, 2018.
Juno-award-winning Inuk singer-songwriter Susan Aglukark has had tremendous success blending languages (Inuktitut and English) to tell the stories of her people through popular music. She has now published the first in a planned series of six picture books intended for both Inuit and non-Inuit readers, a series that celebrates the resilience of the Inuit people. The series focuses on a period of tremendous change, beginning late in the nineteenth century, when more and more European traders began to regularly visit Inuit camps. This changing world is seen through the eyes of a young Inuk girl named Ukpik.
Ukpik is a happy little girl who is excitedly seeking the perfect name for her new puppy. A precocious child, she is eager to try new things, to ask questions, and to share newfound knowledge with the other children in camp. She is eager to understand and embrace the European tools for which her family trades—in this story, it is cutlery (knives, forks, and spoons)—but she wonders if these objects will forever change their happy way of life. Ukpik’s grandmother offers reassurance and helps the little girl to thoughtfully consider her family’s place in a rapidly changing world.
As she has done so successfully with her music, Aglukark has peppered Una Huna? with Inuktitut words that will introduce young readers to Inuit culture without confusing them or significantly slowing the pace of the story. The charming illustrations by Amanda Sandland and Danny Christopher are very suitable for children and lend a fairly realistic sense of place. Appropriately, this book was published by the first independent publishing company in Nunavut; Inuit-owned Inhabit Media seeks to promote and preserve Inuit mythology and traditional knowledge. Una Huna? is highly recommended for readers aged 5 to 7.
Highly recommended: 4 out of 4 starsReviewer: Linda Quirk
Linda taught courses in Canadian Literature, Women's Writing, and Children's Literature at Queen's University (Kingston) and at Seneca College (Toronto) before moving to Edmonton to become a librarian at University of Alberta’s Bruce Peel Special Collections.
A Bevy of 4-Star Books to Delight Readers
Authors: Desmarais Robert 
Published: April 2019

Dear Readers,
We are delighted to recommend a diverse group of children’s books for your reading pleasure. Remarkably, more than half of the books in this issue were “highly recommended” by Deakin reviewers, so I wanted to take this opportunity to explain the significance of a 4-star rating. Our reviewers are looking for books with captivating stories from start to finish that are worthy of reading over and over. Many of the books we review are illustrated, so we also pay close attention to the artful marriage of words and pictures. A four-star rating demands excellence in the book’s design and writing quality, and of course, the book should have a story that inspires readers to think and learn. It certainly isn’t easy to earn a 4-star review from our reviewers, and for that reason, I would like to congratulate the authors, illustrators, and publishing teams who produced the eight books that earned a 4-star rating in this issue: Cheerful Chick, Down by the River, Gluten Free is Part of Me, Here Comes Rhinoceros, That’s Not Hockey, Una Huna?: What Is This?, What’s My Superpower?, and You Hold Me Up. The creators of these excellent books deserve commendation for a job well done, and we owe them our thanks for capturing our interest and imagination.
I am thrilled to see so many books recommended by Deakin reviewers for their overall quality and I hope you’ll find something in this issue to fire your imagination.
Happy reading!
Robert Desmarais, Managing Editor
Metastasis of breast carcinoma to trigeminal nerve with numb chin syndrome: a case report and literature review
Authors: Lian Ya Hui , Kong De Zheng , Wang Lin Jing , Wang Chun Mei , Meng Yang Yang , Zhou Hong Wei 
Published: April 2019

Abstract
Background

In general, common metastatic pathways for breast carcinoma include lung, liver, and bone. Described herein is a rare case of breast carcinoma metastasis to the trigeminal nerve. And numb chin syndrome(NCS) has a certain suggestive effect on the recurrence or progression of cancer patients.

Case presentation

a 54-year-old Chinese female was admitted to our hospital for progressive anaesthesia of the lower left lip and chin. She was diagnosed as breast ductal carcinoma 9 years ago. The brain MRI demonstrated dumbbell-shaped involvement of left trigeminal nerve which extended to left temporal lobe. Then we treated patient with radiotherapy, the patient’s numbness relieved rapidly.

Conclusion

After review and analysis of the case, we found numb chin syndrome (NCS) is a “red flag” symptom of malignancy.1 When cancer patients develop numb chin syndrome(NCS), we need to be alert to the possibility of distant metastasis. This case also suggests that clinicians should pay attention to the possibility of breast cancer metastasis to the trigeminal nerve.
Pituitary apoplexy accompanying temporal lobe epilepsy as a complication: case report
Authors: Shijo Katsunori , Yoshimura Sodai , Mori Fumi , Yamamuro Shun , Sumi Koichiro , Oshima Hideki , Yoshino Atsuo 
Published: April 2019

Abstract
Abstract
Background: Pituitary apoplexy is an acute clinical syndrome caused by infarction and/or hemorrhage of pituitary adenoma, which typically presents with severe headache, visual deterioration, and endocrine abnormalities. However, temporal lobe epileptic seizure has not been viewed as a symptom of pituitary apoplexy in the literature.
Case presentation: To elucidate further such a rare complication of temporal lobe epilepsy, we describe here the rare clinical manifestations of a 55-year-old previously healthy male with pituitary apoplexy harboring headache, combined palsies involving cranial nerves III to VI, endocrinologic disturbances, and temporal lobe epilepsy. In addition, we discuss the temporal lobe epilepsy of pituitary adenoma based on the literature.
Conclusion: Although further accumulation of clinical data is needed, we would like to emphasize the importance of recognition of temporal lobe epilepsy due to pituitary apoplexy, and suggest that early surgery should be considered as an option in patients with such a rare complication.
Investigation of muscle transcriptomes using gradient boosting machine learning identifies molecular predictors of feed efficiency in growing pigs
Authors: Messad Farouk , Louveau Isabelle , Koffi Basile , Gilbert Hélène , Gondret Florence 
Published: April 2019

Abstract
Background
Improving feed efficiency (FE) is a major challenge in pig production. This complex trait is characterized by a high variability. Therefore, the identification of predictors of FE may be a relevant strategy to reduce phenotyping efforts in breeding and selection programs. The aim of this study was to investigate the suitability of expressed muscle genes in prediction of FE traits in growing pigs. The approach considered different transcriptomics experiments to cover a large range of FE values and identify reliable predictors.

Results

Microarrays data were obtained from longissimus muscles of two lines divergently selected for residual feed intake (RFI). Pigs (n = 71) from three experiments belonged to generations 6 to 8 of selection, were fed either a diet with a standard composition or a diet rich in fiber and lipids, received feed ad libitum or at restricted level, and weighed between 80 and 115 kg at slaughter. For each pig, breeding value for RFI (RFI-BV) was estimated, and feed conversion ratio (FCR) and energy-based feed conversion ratio (FCRe) were calculated during the test periods. Gradient boosting algorithms were used on the merged muscle transcriptomes to identify very important predictors of FE traits. About 20,405 annotated molecular probes were commonly expressed in longissimus muscle across experiments. Six to 267 expressed muscle genes covering a variety of biological processes were found as important predictors for RFI-BV (R2=0.63-0.65), FCR (R2=0.61-0.70) and FCRe (R2=0.49-0.52). The error of prediction was less than 8% for FCR. Altogether, 56 predictors were common to RFI-BV and FCR. Expression levels of 24 target genes were further measured by qPCR. Linear regression confirmed the good accuracy of combining mRNA levels of these genes to fit FE traits (RFI-BV: R2=0.73, FRC: R2=0.76; FCRe: R2=0.75). Stepwise regression procedure highlighted 10 genes (FKBP5, MUM1, AKAP12, FYN, TMED3, PHKB, TGF, SOCS6, ILR4, and FRAS1) in a linear combination predicting FCR and FCRe. In addition, FKBP5 and expression levels of five other genes (IGF2, SERINC3, CSRNP3, EZR and RPL16) significantly contributed to RFI-BV.

Conclusion
It was possible to identify few genes expressed in muscle that might be reliable predictors of feed efficiency.
Advancing Clinical Cohort Selection with Genomics Analysis on a Distributed Platform
Authors: Smith Jaclyn Marjorie , Lathara Melvin , Wright Hollis , Hill Brian , Ganapati Nalini , Sriniv Ganapati , Denny Christopher T 
Published: April 2019

Abstract
Background

The affordability of next-generation genomic sequencing and the improvement of medical data management have contributed largely to the evolution of biological analysis from both a clinical and research perspective. Precision medicine is a response to these advancements that places individuals into better-defined subsets based on shared clinical and genetic features. The identification of personalized diagnosis and treatment options is dependent on the ability to draw insights from large-scale, multi-modal analysis of biomedical datasets. Driven by a real use case, we premise that platforms that support precision medicine analysis should maintain data in their optimal data stores, should support distributed storage and query mechanisms, and should scale as more samples are added to the system.

Results

We extended a genomics-based columnar data store, GenomicsDB, for ease of use within a distributed analytics platform for clinical and genomic data integration, known as the ODA framework. The framework supports interaction from an i2b2 plugin as well as a notebook environment. We show that the ODA framework exhibits worst-case linear scaling for array size (storage), import time (data construction), and query time for an increasing number of samples. We go on to show worst-case linear time for both import of clinical data and aggregate query execution time within a distributed environment.

Conclusions

This work highlights the integration of a distributed genomic database with a distributed compute environment to support scalable and efficient precision medicine queries from a HIPAA-compliant, cohort system in a real-world setting. The ODA framework is currently deployed in production to support precision medicine exploration and analysis from clinicians and researchers at UCLA David Geffen School of Medicine.
Nutritional intakes and associated factors among tuberculosis patients: a community-based cross-sectional study in China
Authors: ren zhewen , Zhao Fei , Chen Hui , Hu Dongmei , Yu Wentao , Xu Xiaoli , Lin Dingwen , Luo Fuyi , Fan Yueling , Wang Haijun , Cheng Jun , Zhao Liyun 
Published: April 2019

Abstract
Objectives

This study evaluated nutrient intakes of tuberculosis (TB) patients and examine their associated factors.

Methods

In this cross-sectional study, 300 adult TB patients were enrolled in two poverty counties in China. Nutrient intakes were evaluated through two consecutive 24-h dietary recalls and compared with the Chinese Dietary Reference Intakes (DRIs) 2013. Corresponding information for local general population was derived from 2015 China Health and Nutrition Survey.

Results

The mean daily energy and protein intakes of TB patients were below Recommend Nutrient Intake (RNI) and Adequate Intake (AI) in both genders, and intakes of many micronutrients, except for vitamin E and sodium, were insufficient. Compared with those for local general population, TB patients’ intakes of all the macronutrients and micronutrients were lower (p<0.05) except total fat. In addition, Proportions of people with lower macronutrient or micronutrient intakes were higher in TB patients than in general population except for Vitamin E intake. Being unemployed was a risk factor for low energy intake and higher household income level was a protective factor (p<0.05), and out-home-eating was a protective factor for low protein intake (p<0.01).

Conclusions

In poor areas in China, the intakes of macronutrients and most micronutrients in TB patients were less than in general population, and were inadequate compared with DRIs, especially unemployed patients and patients with low household income level, suggesting the importance of health promotion to TB patients about significance of nutrition and further interventions in TB patients’ nutritional intakes.
Performance and Impact of GeneXpert MTB/RIF® and Loopamp MTBC Detection Kit® Assays on Tuberculosis Case Detection in Madagascar
Authors: Rakotosamimanana Niaina , Lapierre Simon Grandjean , Raharimanga Vaomalala , Raherison Mamy Serge , Knoblauch Astrid , Raherinandrasana Antso , Rakotoson Andrianantenaina , Rakotonirina Julio , Rasolofo Voahangy 
Published: April 2019

Abstract
Background

Tuberculosis rapid molecular assays, including GeneXpert MTB/RIF® and Loopamp MTBC Detection Kit®, are highly sensitive and specific. Such performance does not automatically translate in improved disease control and highly depends on their use, local epidemiology and the diagnostic algorithms they’re implemented within. We evaluate the performance of both assays and assess their impact on additional cases notification when implemented within WHO recommended tuberculosis diagnostic algorithms in Madagascar.

Methods

548 presumptive pulmonary tuberculosis patients were prospectively recruited between November 2013 and December 2014 in Antananarivo, Madagascar, a high TB incidence sub-Saharan African urban setting. Both molecular assays were evaluated as first line or add-on testing following negative smear microscopy. Based on locally defined assay performance characteristics and using country National Tuberculosis Control Program data, we measure the impact of both assays and WHO-recommended diagnostic algorithms on additional tuberculosis case notifications at national level.

Results

High sensitivity and specificity was confirmed for both GeneXpert MTB/RIF® (86.6% (95% CI 81.1-90.7%) and 97.4% (95% CI 94.9-98.8%)) and Loopamp MTBC Detection Kit® (84.6% (95% CI 78.9-89.0%) and 98.4% (95% CI 96.2-99.4%)). Implementation of GeneXpert MTB/RIF® and Loopamp MTBC Detection Kit® increased tuberculosis diagnostic algorithms sensitivity from 73.6% (95% CI 67.1-79.3%) up to 88.1% (95% CI 82.8-91.9%). This increase was highest when molecular assays were used as add-on testing following negative smear microscopy. As add-on testing, GeneXpert MTB/RIF® and Loopamp MTBC Detection Kit® respectively improved case detection by 23.8% and 21.2% (p<0.05) corresponding to 5375 and 4788 potential additional case per year at national level.

Conclusion

Including GeneXpert MTB/RIF® or Loopamp MTBC Detection Kit® molecular assays for TB detection on sputum samples from presumptive TB cases can significantly increase case notification in TB diagnostic centers. The TB case detection rate is further increased when those tests are use as second-line follow-on testing following negative smear microscopy results. A country wide scale-up and digital integration of molecular-based TB diagnosis assays shows promises for TB control in Madagascar.
A combined strategy for postoperative patients with central nervous system infections caused by XDR/PDR Acinetobacter baumannii: a retrospective study
Authors: Chang Jianbo , Chen Yihao , Wang He , Ma Xiaojun , Zhang Xiao , Wu Hao , Ma Baitao , Zuo Wei , Wang Renzhi , Ma Wenbin , Wei Jun-ji 
Published: April 2019

Abstract
Background
Postoperative central nervous system infections (PCNSIs) caused by extensively drug-resistant (XDR) or pandrug-resistant (PDR) Acinetobacter baumannii are rare but intractable problems. To investigate a potential combined strategy to treat AB organisms that are resistant to not only meropenem but also colistin.
Methods
We retrospectively reviewed cerebrospinal fluid positive culture isolates of AB in patients who underwent neurosurgery. Medical records were collected by standard forms and analyzed.
Results
16 patients met the criteria and most patients were middle-aged men who had undergone craniotomy or endonasal transsphenoidal surgery. 68.8% AB isolates were XDR bacteria, and 18.8% isolates were PDR bacteria. 12 patients were treated by meropenem-based regimen strategy. Another 4 patients were administered tetracycline-based regimens. 93.8% patients were treated with therapeutic drainage, and strict hygiene rules were followed. Finally, 12 patients survived their infections, and the average Glasgow Outcome Scale score was 2.9±1.4 at discharge. And the mortality rates of carbapenem-resistant AB (CRAB) were 8.3%.
Conclusions
PCNSIs caused by XDR/PDR AB are a rare and serious complication. Combined therapy based on the individual situation, including appropriate antimicrobial agents, surgical management and strict hygiene management, might be an effective therapeutic strategy.
Experience of application of topichesky naturopathic means for patients with ent pathology
Authors: Nikiforova G. N. , Svistushkin V. M. , Karapetian L. S. 
Published: April 2019

Post-traumatic reactive changes in the area of ENT-organs can cause cosmetic defects, contribute to the development of infectious and inflammatory processes. The formation of limited edema and bruising is natural after certain even adequately performed surgical interventions. In clinical practice, the question arises of the effective and safe use of local drugs that have anti-inflammatory, anti-edema and analgesic effects to accelerate the course of post-traumatic reactive processes. Naturopathic agents have high safety, sufficiently pronounced anti-inflammatory, analgesic and reparative effect. The drug based on arnica mountain (Arnica montana) is a unique topical drug that only contains fresh Arnica plants in a concentration of 7% TM. Efficiency and high safety of this drug allows us to recommend it for the treatment of bruises and hematomas of the skin in the area of ENT-organs, including after surgical interventions.
Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats
Authors: Shin Sarah , Kim No Soo , Kim Young Ah , Oh Hea Ry , Bang Ok-Sun 
Published: April 2019

Background:Traditionally, Phragmitis rhizoma has been prescribed to relive a fever, vomiting, dysuria, and constipation, and to promote secretion of fluids. In addition, recent studies have reported its efficacy as a diuretic and antiemetic. Our previous study demonstrated that the Phragmitis rhizoma aqueous extract (EPR) ameliorates docetaxel (DTX)-induced myelotoxicity.Aim and Objective:This study was aimed to investigate the effects of EPR on the pharmacokinetics of DTX in Sprague–Dawley rats.Materials & Methods:The animals received an intravenous injection of DTX (5 mg/kg) with or without oral EPR (100 mg/kg) pretreatment for 1 or 6 days. The pharmacokinetics of plasma DTX was analyzed using an ultra-performance liquid chromatography-tandem mass spectrometry system, and pharmacokinetic parameters were estimated via noncompartmental analysis.Results:Relative to the control group (DTX alone), EPR pretreatment did not affect significantly the overall profiles of plasma DTX levels. Consecutively pretreated EPR for 6 days slightly altered AUC0-t and Cmax of DTX by 122 and 145.9%, respectively, but these data did not reach the threshold of statistical significance (p > 0.05).Conclusion:These results indicate that DTX exposure may not be affected by EPR treatment at the dose level used in this study, suggesting that oral EPR can be used safely when taken with intravenously injected DTX. However, further studies under the stringent conditions are needed when chronic treatment of EPR and anticancer drug.
Eating Disorders in Athletes: From Risk Management to Therapy
Authors: Milano Walter , Milano Luca , Capasso Anna 
Published: April 2019

Background:
Balanced sporting activity should be considered a resource in the treatment of
eating disorders (ED), in particular of the BED and in obesity and, if conducted and guided by expert
preparers and rehabilitators, in some forms of anorexia and in bulimia.

Objective:
To assess the role of excessive physical activity, predominantly interfering with daily activities
by ultimately resulting in greater energy consumption leading to weight loss, and study the diagnostic
criteria of bulimia and anorexia nervosa.

Methods:
A number of literature studies also report the presence of ED among athletes. A 2004 study
reported that the prevalence of eating disorders in sports would be 13.5% compared to 4.5% of the
control subjects.

Results:
In general, nutrition is used as a tool for improving performance not only of athletes but also
of technicians and coaches. But in the presence of factors of vulnerability towards ED, the tendency to
manipulate the weight can result in an eating disorder or the so-called athletic anorexia or the RED-S.

Conclusion:
It is important to emphasize that not only do professional athletes suffer from it, but also
good-looking amateurs and laypersons.