bluuebunny/crossref_metadata_2025_split huggingface dataset:
GC-MS profiling and in silico pharmacokinetic properties of essential oils hydrodistilled from leaves of Capparis tomentosa and Cadaba rotundifolia
Authors: Degfie Teshome , Endale Milkyas , Begna Tekalign , Jung Chuleui , Dekebo Aman 
Published: November 2024

In Ethiopian traditional medicine Capparis tomentosa treats tuberculosis, diarrhea, epilepsy, and malaria, while Cadaba rotundifolia for arthritis, tonsillitis and snake bites. Essential oils from the plant leaves were hydro-distilled using Clevenger apparatus and analyzed by GC-MS. SwissADME and ProTox-II assessed drug-likeness and ADMET of major compounds. Leaf extracts were tested against three bacterial strains using agar disc-diffusion method. GC-MS identified 25 compounds (89.7%) in C. tomentosa and 23 (95.47%) in C. rotundifolia. Major compounds (1-15) followed Lipinski's and Veber's rules, with compounds 2, 7, 9, and 12 in the Boiled-Egg's yellow region. Compounds 3, 4, 7, 11, and 12 had LD50 >5000 mg/kg, indicating lower toxicity than chloramphenicol (LD50 = 1500 mg/kg). At 5 μg/mL, C. tomentosa oil showed stronger inhibition against E. coli (10±0.0 mm) and P. aeruginosa (9.0±0.25 mm), its methanol and n-hexane extracts against E. coli (9.85±0.14 mm) and P. aeruginosa (8.1±0.19 mm), respectively. C. rotundifolia oil was more effective against P. aeruginosa (8±0.5 mm) than chloramphenicol (6.9±0.51 mm), while its n-hexane and methanol extracts inhibited P. aeruginosa (8.1±0.17 mm) and E. coli (8.0±0.31 mm), respectively. These findings support traditional medicinal use of the studied plants, and highlight their potential as sources of bioactive compounds.
KEY WORDS: Capparis tomentosa, Cadaba rotundifolia, Essential oils, GC-MS, In silico pharmacokinetic
Bull. Chem. Soc. Ethiop. 2025, 39(2), 351-366.
DOI: https://dx.doi.org/10.4314/bcse.v39i2.13
Pharmacognostic evaluation and development of HPLC fingerprint for standardisation of <i>Waltheria indica</i> l. (Malvaceae)
Authors: Oyetunde Y.M. , Sonibare M.A. , Oludipe E.O. , Anang D.M. 
Published: November 2024

Studies have supported ethnobotanical claims on Waltheria indica L. Malvaceae. However, its standardisation parameters are yet to be defined. This study conducted pharmacognostic evaluation and High-Performance Liquid Chromatography (HPLC) to develop standards for Waltheria indica. The plant was collected, identified, and authenticated. The morphological and anatomical characters were studied by organoleptic evaluation and microscopy, respectively. Physicochemical constants and phytochemical contents were determined. Chromatographic fingerprints of the leaf, stem, and root powders were obtained, and peaks were identified and quantified based on phenolic standards. Physical characters of Waltheria indica were described. Photomicrographs showed abundant stellate trichomes in leaves and stem of the plant. The vascular bundles were arranged in amphicribral form with endarch xylems. The adaxial surface of the leaf has straight epidermal cells with anisocytic and diacytic stomata, while the abaxial surface has wavy epidermal cells with only anisocytic stomata. The alcohol and water extractives values of leaf, stem, and root are (22.2%, 11.8%, and 14.44%) and (15.47%, 7.6% and 7.33%) respectively. Moisture content (6.62%, 2.78%, and 3.63%) and ash values (7.77%, 2.73%, and 2.33%) were within pharmacopoeia limits. Steroids, terpenoids, saponins, tannins, phenols, flavonoids, cardiac glycosides, anthraquinone, and alkaloids were present in all plant parts. Chromatographic fingerprints of plant parts showed unique peaks for phenolic standards. All plant parts had 4-hydroxybenzoic acid, epigallocatechin gallate, and epicatechin, with epicatechin most abundant in the leaf (1,371,061 ng/g). The standardisation parameters developed would be helpful in monograph preparation for Waltheria indica.
Physique en première année d’université : que nous apprend une analyse ancrée en didactique des mathématiques ?
Authors: Gueudet Ghislaine , Lebrun Nathalie , Vandebrouck Fabrice 
Published: November 2024

This text reports on a workshop of the DEMIMES thematic school, the aim of which was to discuss how didactic theories can equip teachers in higher education to analyse exercises and problems texts and anticipate student difficulties. We present an analysis of a first-year university physics problem using theoretical tools from mathematics didactics: the anthropological theory of the didactic and the activity theory specific to didactics. We have chosen a Newtonian mechanics problem concerning the fall of a ball in a liquid, whose mathematical treatment involves vectors and a differential equation. We introduce the theoretical tools used and the problem chosen, then present the analyses, and discuss the contributions of the two theories. The workshop also showed that didactic analyses could shed light on the differences between the mathematics used in mathematics courses and those used in physics courses at university.Ce texte rend compte d’un atelier de l’école thématique DEMIMES, dont l’objectif était de discuter comment les théories de didactique peuvent outiller les enseignants du supérieur pour analyser des énoncés et anticiper des difficultés d’étudiants. Nous présentons l’analyse d’un énoncé de physique de niveau première année d’université avec des outils théoriques issus de la didactique des mathématiques : la théorie anthropologique du didactique et la théorie de l’activité spécifiée à la didactique. Nous avons retenu un énoncé de mécanique Newtonienne portant sur la chute d’une bille dans un liquide, dont le traitement mathématique implique notamment des vecteurs et une équation différentielle. Nous introduisons les outils théoriques mobilisés et l’énoncé choisi, avant de présenter les analyses et de discuter les apports des deux théories choisies. L’atelier a de plus montré que les analyses didactiques pouvaient éclairer les différences entre les mathématiques des cours de mathématiques et celles utilisées en cours de physique à l’université.
El Currículo Nacional Base de educación preprimaria y la metodología Montessori
Authors: Galindo Yesenia Elizabet 
Published: November 2024

OBJETIVO: evaluar la función de la metodología Montessori en el desarrollo de competencias establecidas en el Currículo Nacional Base de nivel Preprimario. MÉTODO: la metodología que sustentó la investigación fue el paradigma sociocrítico, un enfoque cualitativo, con un diseño de estudio fenomenológico, alcance exploratorio descriptivo y con una muestra de 22 participantes. RESULTADOS: los resultados revelaron la necesidad de formación especializada y desarrollo profesional continuo para las maestras que buscan integrar estos enfoques con éxito. Además, se identificaron beneficios tangibles en el desarrollo integral de los estudiantes, incluyendo una mayor autonomía y habilidades sociales. La flexibilidad y la adaptabilidad emergieron como elementos críticos para una implementación efectiva. Comparaciones con estudios previos respaldan estos hallazgos, destacando la importancia de abordar las necesidades formativas y fomentar la flexibilidad pedagógica en el proceso de enseñanza - aprendizaje. CONCLUSIÓN: el Currículum Nacional Base de Educación Preprimaria establece las pautas y objetivos educativos para los primeros años de formación de los niños. La metodología Montessori ofrece un enfoque pedagógico centrado en el respeto por el niño como individuo y en su capacidad innata para aprender a través de la exploración y la experiencia práctica. La implementación de la metodología Montessori dentro del marco del Currículum Nacional Base puede enriquecer la experiencia educativa de los niños, fomentando no solo el aprendizaje académico sino también habilidades para la vida.
Impacto de las tecnologías de la información y la comunicación (TIC) en los procesos educativos: un estado del arte
Authors: Burbano Cerón María Jeimy , León Hernández Sandra Milena , Andrade Salazar José Alonso 
Published: November 2024

PROBLEMA: Las Tecnologías de la Información y la Comunicación (TIC) han transformado la educación, pero su implementación enfrenta desafíos como la resistencia de algunos educadores y las desigualdades en el acceso. OBJETIVO: Analizar el impacto de las TIC en la educación, destacando su papel relevante en la mejora de los procesos de enseñanza y aprendizaje y en formación continua de estudiantes y docentes. MÉTODO: Es un estudio cualitativo de tipo documental con base en la revisión de literatura relevante sobre la evolución de las TIC en la educación, seleccionando estudios que destacan tanto los beneficios como los desafíos en su implementación, así como la necesidad de formación continua para docentes. RESULTADOS: Las TIC han enriquecido significativamente las metodologías educativas, facilitando la motivación, personalización y flexibilidad del aprendizaje. Sin embargo, persisten barreras como el acceso desigual a la tecnología, especialmente en áreas rurales y en países en desarrollo, y la falta de competencias digitales entre docentes. Además, existen diferencias en la eficiencia de las TIC según los contextos educativos, lo que resalta la necesidad de formación continua y estrategias adaptadas. CONCLUSIÓN: Las TIC son esenciales para una educación inclusiva y accesible, pero es necesario desarrollar estrategias pedagógicas contextualmente ajustadas para superar las brechas existentes en los procesos de enseñanza y aprendizaje para maximizar su eficiencia. También se evidenció que, en algunos casos, la implementación de TIC sin una adecuada planificación pedagógica puede generar más dificultades que beneficios.
Actitud hacia la investigación científica en estudiantes de Licenciatura en Enfermería
Authors: Martín Sirín Maria Regina 
Published: November 2024

OBJETIVO: determinar la actitud hacia la investigación científica que tienen los estudiantes del último año de la licenciatura de enfermería en una universidad privada de la ciudad de Guatemala. MÉTODO: se realizó con enfoque mixto, alcance descriptivo y diseño anidado o incrustado concurrente de modelo dominante. La muestra estuvo conformada por 84 estudiantes, seleccionados por conveniencia. El instrumento se conformó en dos secciones, la primera un cuestionario y la segunda preguntas abiertas y múltiples que fueron anidadas por el primer método dominante. RESULTADOS: los datos cuantitativos demostraron que la actitud hacia la investigación, es positiva, afirmando el 57.14% que le gustaba la investigación. Los participantes en la sección cualitativa, sugirieron que la investigación en Guatemala puede mejorar a través de diplomados, cursos, investigación desde una edad temprana, apoyo a docentes, campo de investigación, motivación y recursos. Las universidades pueden tomar en cuenta: talleres, capacitaciones, tecnología, internet, bibliotecas, laboratorios, tiempo, elaboración de artículos, tesis y publicaciones de revistas. La actitud negativa se identificó al considerar que la investigación necesitaba dedicación y tener que leer, otros refirieron no querer contar con ninguna experiencia, incluso eliminar cursos de investigación. CONCLUSIÓN: el estudio determinó que los estudiantes de la licenciatura en enfermería tendían a una actitud positiva, sin embargo, las actitudes negativas mostradas como desinterés en la lectura o en los cursos de investigación, deben ser atendidas.
ԳԵՐՆՍՏՈՂ ԳՐՈՒՆՏՆԵՐԻ ՍԱՀՔԻ ԴԻՄԱԴՐՈՒԹՅԱՆ ՕՐԻՆԱՉԱՓՈՒԹՅՈՒՆՆԵՐԸ ԽՈՆԱՎԱՑՄԱՆ ՊԱՅՄԱՆՆԵՐՈՒՄ ԽՏԱՑՆՈՂ ԲԵՌՆՎԱԾՔՆԵՐԻ ՓՈՓՈԽՈՒԹՅԱՆ ԼԱՅՆ ՄԻՋԱԿԱՅՔՈՒՄ
Authors: Հայրոյան Ս․Հ․ , Եղիազարյան Մ.Թ. 
Published: November 2024

Strength behavior of water saturated subsidented soils is studied. A linear dependence of relative subsidence deformation of compacting stresses while σz<Psl,0, becoming to power dependence when σz>Psl,0 is found out experimentally. In conditions of water saturation the shear resistance chart represents a broken line, which vertex corresponds to the initial subsidence value. Necessity to determine the shear resistance arguments for each compacting stress σz>Psl,0 on reverse branch of compression curves on Nichiporovich method is established.
ПРОТИВОДЕФОРМАЦИОННЫЕ МЕРОПРИЯТИЯ, ПРИМЕНЯЕМЫЕ ПРИ НАБУХАНИИ ГРУНТОВ ГИДРОТЕХНИЧЕСКИХ СООРУЖЕНИЙ
Authors: Айроян Саркис Г. 
Published: November 2024

The article is devoted to the application of deformation preventing measures for dams constructed out of swelling soils. Laboratory and fields tests have shown the relation between swelling pressure-compaction tension has a nonlinear character. On the basis of received dependence it is proposed to compensate the swelling pressure by the load calculated with the formula h = 0,3 σsw /ρ, where ρ is a soil density, σsw is a swelling pressure.
Transformative Narratives: Unveiling Sexual Violence Survivors' Stories Through Educational Theatre in Kosovo
Authors: Ferati Marigona Bekteshi 
Published: November 2024

Objective: The doctoral thesis presents educational theatre as a therapeutic and awareness-raising approach for supporting female survivors of wartime sexual violence in Kosovo. It promotes social acceptance, educates survivors' families, and helps them come to terms with the traumatic experiences of their loved ones.

Theoretical Framework: This research employs educational theater to spotlight female survivors of sexual violence post-Kosovo-Serbia war, aiming to reshape societal views and build empathy. With 20,000 estimated affected, it underscores urgent needs for mental health support and social integration.

Method: The dissertation employs observation, participatory observation, analysis, theatrical performance staging, and statistical data analysis. Conducted from 2020-2021, it centers on the original drama Queens without Crowns, directed by Marigona Bekteshi Ferati, as a key contribution to the research.

Results and Discussion: The 2020-2021 research led to the performance Queens without Crowns, exploring social exclusion, audience perception shifts, survivor support, and family perspective changes. Through educational theater, it documents survivors’ experiences, fostering empathy, understanding, and advocacy for female rape victims' rights and healing.

Research Implications: The theatrical performance aims to transform spectators' views on wartime rape victims, offering survivors emotional support by bringing their experiences to the stage. Families in Kosovo are encouraged to reconsider their perspectives on the traumatic experiences endured by their loved ones.

Originality/Value: This study pioneers the use of educational theater in Kosovo to help sexual violence survivors overcome trauma, reduce stigma, and support social integration. It aims to be part of therapeutic approaches for coping with wartime rape trauma among victims in Kosovo.
Local Regulations as Moderation in the Influence of Community Knowledge Sharing on the Business Performance of Traditional Medicine SMES
Authors: Artono  , Setiawan Margono , Surachman  , Prabandari Sri Palupi 
Published: November 2024

Objective: This study aims to analyze the impact of community knowledge sharing (CKS) on the business performance (BP) of traditional medicine SMEs and to analyze the moderating role of local regulations (LR) in this relationship.

Theoretical Framework: The theoretical framework used focuses on the importance of CKS and regulations in supporting business performance through increasing shared knowledge and compliance with regulations.

Method: The research method used is a quantitative survey by distributing questionnaires to 184 owners and managers of traditional medicine SMEs in East Java. Data analysis was carried out using structural equation modeling (SEM).

Results and Discussion: The results of the study indicate that CKS does not have a significant effect on the business performance of SMEs. Likewise, the moderating role of local regulations is not significant in strengthening the relationship between CKS and business performance. However, these results highlight that increasing direct knowledge sharing may not be enough to drive the business performance of traditional medicine SMEs, which can be caused by resource constraints, local culture, and regulatory complexity.

Research Implications: The implications of this study suggest that to improve the performance of traditional medicine SMEs, local policies need to focus more on other factors such as product innovation, better regulatory compliance, and digital marketing.

Originality/Value: The originality of this study lies in the analysis of the combination of CKS and LR in the context of traditional medicine SMEs that have previously been rarely studied.
Dermatitis atópica en adultos: análisis observacional de 200 pacientes
Authors: Mónaco Marina , Luna Paula Carolina , Frare Cindy , Debernardi María Emilia , Tirelli Luciana Laura , Panizzardi Anabel , Larralde Margarita 
Published: November 2024

Antecedentes: la dermatitis atópica (DA) es una dermatosis inflamatoria crónica caracterizada por xerosis, prurito y eccema. El diagnóstico es clínico y el tratamiento depende de su gravedad; los casos leves suelen controlarse con medicación tópica, mientras que los moderados/severos requieren tratamiento sistémico. Afecta con mayor frecuencia a la edad pediátrica, por lo que son limitados los estudios en adultos.
Objetivos: describir las características epidemiológicas y clínicas, y los tratamientos en pacientes adultos ambulatorios con DA.
Diseño: se realizó un trabajo retrospectivo, observacional, descriptivo y analítico.
Materiales y métodos: se recolectaron las variables demográficas, clínicas y tratamientos de las historias clínicas de pacientes adultos mayores de 18 años con DA entre 2019 y 2023. Se compararon los antecedentes y los factores asociados entre los tipos de severidad: leve, moderado y severo.
Resultados: de los 200 pacientes, el 62,5% fue de sexo femenino. El 36% presentó asma y el 25,5% rinitis. Los pacientes severos tuvieron mayor frecuencia de asma y rinitis. El metotrexato se utilizó más frecuentemente en la enfermedad moderada y severa, y el 24,7% de los pacientes con enfermedad severa requirió dupilumab.
Conclusiones: en nuestro país son limitadas las investigaciones sobre los pacientes adultos con DA. La gravedad de la enfermedad se asocia con mayor frecuencia a comorbilidades. En las formas leves predominaron los tratamientos tópicos; la fototerapia se usó como un escalón intermedio entre las formas moderadas y graves, y las drogas innovadoras en las formas graves. Es necesario realizar más estudios de calidad que evalúen las diferencias en las comorbilidades y la evolución clínica según el espectro de gravedad.
The Impending Global Challenge of Antimicrobial Resistance: A Call for Urgent Action
Authors: Giri Purushottam , Aikat Aditi 
Published: November 2024

Antimicrobial resistance (AMR) is a critical global health issue driven by antibiotic misuse and overuse in various sectors, leading to the emergence of resistant microorganisms and represents an impending pandemic. Against the backdrop of COVID-19 pandemic, conflicts, and the escalating impact of anthropogenic climate change, the emergence and rapid escalation of antimicrobial resistance (AMR) represent one of the most significant and imminent global public health threats of the 21st century.(1) As bacteria, viruses, fungi, and parasites increasingly evolve resistance to drugs that once treated infections effectively, the ‘superbugs’ such as Methicillin-resistant Staphylococcus aureus (MRSA) and extremely drug-resistant tuberculosis, bacteria that are difficult to treat have emerged. This has brought humanity to the brink of a post-antibiotic era, where re-emergence of common infections is being noted. With resistance on the rise, surgical procedures like organ transplants and cesarean sections, cancer treatments where antibiotics are crucial, and management of life-threatening infectious diseases such as pneumonia, TB, HIV, and malaria are at risk of becoming dangerous due to the high potential for untreatable infections. (2)
Impact of Premenstrual Syndrome (PMS) on Quality of Life among adolescent girls of rural area of Gautam Buddh Nagar: A Cross sectional study
Authors: Chauhan Ambren , Juneja Khushboo , Tyagi Neha , Agarwal Vanshika 
Published: November 2024

Background: PMS causes purposeful impairment in efficiency at school/work, impaired relations with friends, , poor social life activities and home responsibilities affecting quality of life. Aims &Objectives: This study was conducted to estimate the prevalence and symptoms of premenstrual syndrome in adolescent girls and to assess the impact of premenstrual syndrome on their quality of life. Methodology: A cross?sectional study was done among 380 adolescent girls using a pretested semi-structured questionnaire residing in rural field study areas of Department of Community Medicine of a medical college. Results: The prevalence of PMS was reported to be 65.7 % . Head ache (66%) was the most frequent symptom followed by acne (60%) and generalized body ache (57%). Only 37.8% of the girls take their quality of life to be good followed by 1.8% as very good when they were asked about experiencing any negative feelings prior to menses like blue mood, despair ,anxiety etc .Around one fourth (26%) of them reported that they never experience any kind of negative feeling .Conclusion: The adolescent girls are in greatest need for physical , psychological support as they experience the most severe PMS symptoms.
Prevalence of Chronic Otitis Media and Its Associated Hearing Impairment among School Going Children
Authors: Sattien Arun Maran , Oinam Priyokumar Singh , Mosin Babu  , Yumlembam Shandyalata , Thangluah Lalnunpuia 
Published: November 2024

Introduction: Chronic Suppurative Otitis Media (CSOM) is one of the common diseases of the ear, particularly in children which causes significant impact in speech, cognitive, educational and psychological development. In this study we aimed to determine the prevalence of CSOM and associated hearing impairment among school going children aged 5 to 15 years.
Materials and Methods: This was a cross sectional study conducted in the Department of ENT, between September 2018 to August 2020. The study procedures involved completing a questionnaire, otoscopic examination, tuning fork test and audiometric test.
Results: A total of 525 school children were examined for CSOM and associated hearing impairment. Total 57 (10.8%) cases of CSOM were detected with male predominance (6.1% vs 4.8%). The prevalence of CSOM was 10.8%. Unilateral disease was seen in 77.2% and 26.3% had active disease. Around 98.2% had tubotympanic type of disease. This study revealed statistically significant association of CSOM with parent illiteracy, overcrowding, swimming in local pools and recurrent respiratory tract infections.
Conclusion: Health education through school health program, improvement of socioeconomic status and health facilities should be used in early detection and management of this disease thereby reducing the prevalence of CSOM.