bluuebunny/crossref_metadata_2025_split huggingface dataset:
AtDGCR14L contributes to salt‐stress tolerance via regulating pre‐mRNA splicing in Arabidopsis
Authors: Xie Meng , Tadesse Dimiru , Zhang Jin , Yao Tao , Zhang Li , Jawdy Sara S. , Devireddy Amith , Zheng Kaijie , Smith Emily B. , Morrell‐Falvey Jennifer , Pan Chongle , Chen Feng , Tuskan Gerald A. , Muchero Wellington , Chen Jin‐Gui 
Published: November 2024

SUMMARYIn plants, pre‐mRNA alternative splicing has been demonstrated to be a crucial tier that regulates gene expression in response to salt stress. However, the underlying mechanisms remain elusive. Here, we studied the roles of DIGEORGE‐SYNDROME CRITICAL REGION 14‐like (AtDGCR14L) in regulating pre‐mRNA splicing and salt stress tolerance. We discovered that Arabidopsis AtDGCR14L is required for maintaining plant salt stress tolerance and the constitutively spliced and active isoforms of important stress‐ and/or abscisic acid (ABA)‐responsive genes. We also identified the interaction between AtDGCR14L and splicing factor U1‐70k, which needs a highly conserved three amino acid (TWG) motif in DGCR14. Different from wild‐type AtDGCR14L, the overexpression of the TWG‐substituted AtDGCR14L mutant did not change salt stress tolerance or pre‐mRNA splicing of stress/ABA‐responsive genes. Additionally, SWITCH3A (SWI3A) is a core subunit of the SWI/SUCROSE NONFERMENTING (SWI/SNF) chromatin‐remodeling complexes. We found that SWI3A, whose splicing depends on AtDGCR14L, actively enhances salt stress tolerance. These results revealed that AtDGCR14L may play an essential role in crosstalk between plant salt‐stress response and pre‐mRNA splicing mechanisms. We also unveiled the potential role of SWI3A in controlling salt stress tolerance. The TWG motif in the intrinsically disordered region of AtDGCR14L is highly conserved and crucial for DGCR14 functions.
Sharp weak‐type estimate for maximal operators associated to Cartesian families under an arithmetic condition
Authors: Gauvan Anthony 
Published: November 2024

AbstractGiven a set of integers , we consider the smallest family invariant by translations that contains the rectangles
for any and where for integer. We prove that if contains arbitrary large arithmetic progression, then the maximal operator associated to the family satisfies a weak‐type estimate of the form
but does not satisfy a weak‐type estimate of the form
for any nonnegative convex increasing function such that as tends to infinity.
Daily GDF15 treatment has sex‐specific effects on body weight and food intake and does not enhance the effects of voluntary physical activity in mice
Authors: Jeromson Stewart , Akcan Michael , Baranowski Bradley , Arbeau Meagan , Bellucci Annalaura , Wright David C. 
Published: November 2024

AbstractGrowth differentiation factor 15 (GDF15) is a stress‐induced cytokine that suppresses food intake and causes weight loss. GDF15 also reduces voluntary physical activity and, thus, it is not clear whether combining GDF15 with exercise will be beneficial or if reductions in food intake would be offset by decreases in physical activity. We investigated how GDF15 treatment combined with voluntary wheel running (VWR) would impact weight gain, food intake, adiposity and indices of metabolic health in mice. High‐fat fed male and female mice underwent daily GDF15 treatments and were given access to voluntary running wheels, or not, for 11 days. In both sexes, VWR prevented weight gain. In males, GDF15 reduced food intake, as well as attenuated weight gain and the accumulation of adipose tissue, with no additional effect of VWR. In female mice, GDF15 did not impact body weight gain or body composition. GDF15 acutely reduced food intake in female mice but this was followed by a period of rebound hyperphagia and consequently GDF15 did not reduce total food intake in female mice. GDF15 treatment reduced wheel running distance in both sexes. There were main effects of VWR to improve glucose tolerance in female but not male mice. These findings show that GDF15 has sex‐specific effects on food intake and consequently weight gain and adiposity. There is no added benefit of combining GDF15 and voluntary physical activity for weight loss. Adaptive responses to acute caloric restriction induced by GDF15 might limit its effectiveness as a weight loss tool in females.
imageKey points
GDF15 is a stress‐induced signalling factor that reduces food intake and voluntary physical activity.
It is not known whether combining GDF15 treatment with voluntary wheel running would impart beneficial combined effects in attenuating weight gain and the accumulation of adipose tissue.
In the present study, we demonstrate that GDF15 reduces food intake and prevents weight gain in male but not female mice consuming a high‐fat diet and also that combining GDF15 with voluntary wheel running (VWR) does not lead to a greater dampening of weight gain.
In female mice, GDF15 acutely reduced food intake, but this was followed by a period of rebound hyperphagia resulting in no differences in total food intake.
In both sexes, VWR was equivalent, or superior to GDF15 in preventing weight gain.
Quorum sensing regulation of Psl polysaccharide production by
Pseudomonas aeruginosa
Authors: Carey Jeffrey N. , Lamont Sabrina , Wozniak Daniel J. , Dandekar Ajai A. , Parsek Matthew R. 
Published: November 2024

ABSTRACT

Pseudomonas aeruginosa
is a common opportunistic pathogen and a model organism for studying bacterial sociality. A social behavior of
P. aeruginosa
that is critical for its success as a pathogen is its ability to form protective biofilms. Many of
P. aeruginosa
’s social phenotypes are regulated by quorum sensing—a type of cell-cell communication that allows bacteria to respond to population density. Although biofilm formation is known to be affected by quorum sensing, evidence for direct regulation of biofilm production by quorum regulators has remained elusive. In this work, we show that production of the major biofilm matrix polysaccharide Psl in
P. aeruginosa
PAO1 is regulated by the quorum regulators LasR and RhlR in stationary-phase cultures. Secretion of Psl into the culture medium requires LasR, RhlR, and the quorum signal molecules
N
-3-oxo-dodecanoyl-homoserine lactone and
N
-butanoyl homoserine lactone. Psl production in strains unable to synthesize the homoserine lactone signals can be restored by exogenous introduction of the signal molecules. We found that LasR and RhlR perform different roles in the regulation of Psl production: LasR acts at the promoter of the
psl
operon and activates transcription of the Psl biosynthetic genes, while RhlR activates translation of the
psl
transcripts. This work contributes to our understanding of the overlapping but distinct functions of the Las and Rhl quorum-sensing systems and implicates both in the direct regulation of biofilm matrix production.

IMPORTANCE

Pseudomonas aeruginosa
biofilms are responsible for many treatment-resistant infections in humans. Many cooperative behaviors in
P. aeruginosa
are controlled by quorum sensing, but evidence for a direct role of quorum sensing in the regulation of biofilm matrix production has been scant. In this work, we show that the Las and Rhl quorum-sensing systems have distinct roles in regulating production of the matrix polysaccharide Psl and that this regulation happens at the level of transcription (Las) and translation (Rhl) of the
psl
operon. These findings deepen our understanding of overlapping functions of Las and Rhl quorum sensing and the complex regulation of biofilm development in
P. aeruginosa
.
Whole genome sequence of the denitrifying thermophile
Geobacillus thermodenitrificans
subsp.
calidus
DSM 22629
T
Authors: Snook Mary , Ritter Stephan , Pukall Rüdiger , Göker Markus , Seshadri Rekha , Jue Nathaniel K. 
Published: November 2024

ABSTRACT

We present a full genome sequence for the thermophilic denitrifier
Geobacillus thermodenitrificans
subsp.
calidus
DSM 22629
T
(3,408,575 bp, 48.94% GC). This genome includes 3,615 predicted genes, including those needed to reduce nitrate to nitrogen gas. This organism and genome sequence provide valuable resources for future phylogenetic, genomic, and biotechnological research.
Optimization of ultrasound-mediated DNA transfer for bacteria and preservation of frozen competent cells
Authors: Zhang Meng , Tang Rongkang , Li Fang-Xia , Jin Wen-Yu , Guo Jia-Xin , Teng Lin-Zuo , Meng Guangxun , Sansonetti Philippe J. , Gao Yi-Zhou 
Published: November 2024

ABSTRACT

The transformation of DNA into cells is the basis of molecular biology. Commonly employed techniques include heat shock transformation, electro-transformation, conjugation, transduction, and protoplast fusion. Recently, ultrasonic transformation technology has been developed to transfer DNA into competent cells. The transformation conditions, such as temperature and ultrasonic power, were preliminarily studied. However, this technique has not been widely applied because competent cells must be prepared
de novo
. In this study, various factors, such as ultrasonic frequency and power, were optimized for the ultrasonic transformation of
Escherichia coli
. The study found that the optimal conditions for ultrasonic transformation with a defined ultrasonic transformation vial were a frequency of 28 kHz and a power of 80 W. Meanwhile, this research demonstrated that combining the 42°C heat shock conditions with ultrasonic transformation is the most efficient method compared to using only heat shock. Furthermore, the cryoprotective agent ratio for ultrasonic competent cells was investigated and optimized. These findings provide new insights into enhancing transformation efficiency and lay a foundation for the broader application of ultrasonic transformation.

IMPORTANCE
Plasmid transformation is widely applicable in gene expression and modification. As an efficient, non-invasive, and gentle method of transformation, ultrasonic transformation provides a novel approach for strain modification. This research presents new strategies for enhancing transformation efficiency and lays the groundwork for expanding the utilization of ultrasonic transformation.
Correlation of enlarged perivascular spaces in basal ganglion and cancer-associated stroke: a case–control study in China
Authors: Wu Jielong , Hong Ganji , Zheng Liangcheng , Zhao Jiedong , Yu Lu , Jing Chuya , Zhang Qiuhong , Wang Chen , Yuan Xiaodong , Lin Qing , Wang Zhanxiang , Ma Qilin , Fang Jie 
Published: November 2024

IntroductionThe incidence of cancer-associated ischaemic stroke (IS) is increasingly prevalent. This study aimed to assess the levels of enlarged perivascular spaces in basal ganglion (BG-EPVS) in cancer-associated patients who had a stroke compared with the control group, and to investigate the diagnostic utility of BG-EPVS in the context of cancer-associated stroke.MethodA matched case–control study was conducted in Xiamen, China. A total of 184 IS patients (cancer vs control=1:1) were recruited. The severity of BG-EPVS was graded using high-resolution MRI. Patients’ gender, age, clinical risk factors, other imaging changes and laboratory findings information at admission were collected. Logistic regression models were constructed and subgroup analysis by cancer treatment.ResultOverall, 65.22% of the 184 subjects were male, with a mean (SD) age of 68.83±10.52 years. BG-EPVS had a significant influence on cancer-associated stroke (OR=1.85 (95% CI 1.29, 2.71), p=0.001) after adjusting for gender, age, clinical risk factors, other imaging changes and laboratory findings. The area under the curve of the diagnosis model that combined BG-EPVS and other factors was 0.848 (95% CI 0.787, 0.896), significantly higher than the other three models. Subgroup analysis suggested a heightened association between BG-EPVS and cancer-associated stroke within the cancer treatment group.ConclusionIn conclusion, this is the first study to assess the diagnosis values of BG-EPVS on cancer-associated stroke and helps us understand the pathogenesis of cancer-associated stroke. Our findings demonstrate the effectiveness of BG-EPVS in diagnosing IS patients who may carry underlying cancer.
A Locus-Less Literature: the Parallel Geographies of Palestinian Literature during the Tunis Period (1982–1994)
Authors: Abu-Remaileh Refqa , Natour Hanan 
Published: November 2024

Abstract
Emerging from the rubble of the civil war in Lebanon, a group of literary figures sought shelter in Tunis, alongside the PLO and its political factions. Although the ‘Tunis period’ lasted more than a decade, from 1982 to 1994, it remains a neglected period of Palestinian literary history. As part of a larger project that seeks to reconnect disconnected periods of Palestinian literature from 1948 to the present, this article probes the lost Tunis period to better understand Palestinian literature’s North African foray. Using the lens of Arabic literary periodicals, and supported by the tools of Digital Humanities, the article surveys the contents and contributor networks of Tunisian, Moroccan, as well as local and transnational Palestinian periodicals. By tracing literary networks and personal trajectories, the article reveals the parallel geographies of Palestinian literature during a period of intense exile and deterritorialization, an itinerary that includes stops in Tunis, Paris, Casablanca, Nicosia, Jerusalem, and Haifa.
Perdition and Getting Lost in a Lost Short Story by Ghassān Kanafānī: When Hostile Space (al-makān al-muʿādī) Takes Over Narrative Space
Authors: Barbaro Ada 
Published: November 2024

Abstract
The literary space assumes essential semantic importance: from Bakhtin’s structuralist analysis to the reading of space as in the concept of the “production of space” theorized by Henri Lefebvre, the issue of spatiality has unquestionably gained importance in literary studies. When the Jordanian writer Ghālib Halasā translated Gaston Bachelard’s La poétique de l’espace (1957) as Jamāliyyāt al-makān (1984), he observes the French author does not address the hostile space (al-makān al-muʿādī). Halasā admits how this subject has enriched the issue of spatiality with significant data. Building upon these premises, the present contribution aims to offer an interpretation of this hostile spatiality within a story by the Palestinian writer Ghassān Kanafānī. “ʿUlbat zujāj wāḥidah” (Just a glass box)—included in the collection ʿĀlam laysa la-nā (A World Not Our Own, 1963)—is the forgotten short story to which this article intends to devote itself. Within this narrative space, two different forms of spatiality take shape—outside and inside the titular glass box—both characterized by that hostile, unfamiliar trait to which reference has been made thus far, and which we will try to investigate to expose its distinctive features through the actors who act in this space.
“Cauldron of Conspiracy”: Conspiratorial Tropes as Modes of Critique in Ḥabībī’s The Pessoptimist and Saʿdāwī’s Frankenstein in Baghdad
Authors: Labanieh Aya 
Published: November 2024

Abstract
This article uses the concepts of “conspiracy” and “conspiracy theory,” along with their literary tropes, to theorize resistance to the colonial ideals of modernity in Israel and Iraq and to contest the oppressive developmental temporalities associated with this modernity. By analyzing Imīl Ḥabībī’s al-Mutashāʾil (The Secret Life of Saeed, the Pessoptimist, 1974) and Aḥmad Saʿdāwī’s Frānkishtāyn fī Baghdād (Frankenstein in Baghdad, 2013), I show how tropes of conspiracism and conspiratorial thinking are deployed in both of these novels to critique myths of linear progress—often used to justify the Israeli occupation and the U.S. invasion—despite the divergent historical periods and contexts out of which the two texts emerge. In their act of contestation, the novels leverage alternate temporalities in connection to conspiracism, such as the cyclical time of suffering and exploitation, or the apocalyptic time that offers release from said suffering through ending time altogether. Yet in both cases the tropes of conspiracy are ultimately shown to have little explanatory or emancipatory value and high human cost. Both novels thus thematize the analytic and critical limits of conspiracism.
The Leiden Manuscript of the Hundred and One Nights
Authors: Sumi Akiko 
Published: November 2024

Abstract
This paper investigates the Arabic manuscript of the Hundred and One Nights (Miʾat laylah wa-laylah) registered at Leiden University, the Netherlands. First, I prove that the manuscript was once owned by René Basset (1855–1924) by explaining its characteristics and comparing it with references in the French translation of Miʾat laylah wa-laylah by Maurice Gaudefroy-Demombynes (1862–1957). Second, I discuss how the Leiden manuscript is situated in comparison to the other seven texts of the Hundred and One Nights, focusing on the order of the embedded stories and the frame story. The Arabic text of the frame story in the Leiden manuscript is provided at the end. The Leiden manuscript exhibits similar characteristics to some of the other manuscripts of the Hundred and One Nights, while it also contains its own special features.
The Cotton Road
Authors: Mir-Makhamad Basira , Bjørn Rasmus , Boxleitner Kseniia , Spengler Robert N. 
Published: November 2024

Abstract
Cotton is one of the most culturally significant crops in Central Asia today, and it has a complex history, long predating the collective-labour and intensive-irrigation systems of the Soviet period. In this paper, we explore the ancient history of cotton cultivation in Central Asia. We aim to understand when cotton cultivation switched from low-investment to intensive large-scale agriculture and to theorise about the dispersal routes, type of cotton cultivated, and processing systems that existed before the introduction of hybrid forms of cotton from the Americas in the nineteenth century. We incorporate new archaeobotanical data, historical-linguistic evidence and archaeological materials into our discussion. Furthermore, we provide an overview of archaeobotanical evidence from across Europe, Asia and North Africa, aiming to assess common trends in the spread of cotton.
From Zero to Infinity
Authors: Mak Bill M. 
Published: November 2024

Abstract
Both China and India have an ancient mathematical tradition. From the extant records, the encounter of the two traditions took place in Inner Asia, Southeast Asia and in various cosmopolitan centres along the Silk Roads during the first millennium CE. The encounter was documented almost exclusively from the Chinese side, along with fragmentary evidence from Central Asia and the Sino-Indian peripheries, and almost none from India. In this paper, my focus will be the Chinese reception of Indian zero and large numbers, and to evaluate critically the impact they had, or did not have, on the Chinese mathematical tradition, and what the factors for exchange are.
Travelling Formulas
Authors: Bradley Sean T. 
Published: November 2024

Abstract
Plant, animal, and mineral products travelled thousands of miles from Central and South Asia, the Mediterranean, and even Africa to become part of the Chinese pharmacopeia. These products were often used as drugs that were commonly bundled in formulas. While individual drugs were gradually incorporated as part of Chinese medicine, the formula preparations which regularly carried them remain relics of history. By first examining identification and linguistic information, and then looking closely at several formulas containing chebulic myrobalan (Terminalia chebula Retz.) from both Indic and Chinese sources, we can understand better how this drug and its corresponding medical information made its way from South Asia to East Asia, thereby becoming part of the Chinese medical system.
‘Converting’ Knowledge, Culture and Themselves
Authors: Isahaya Yoichi 
Published: November 2024

Abstract
In this paper, I propose a new model of how the Mongol empire connected the various systems used by the subject peoples under their control. I contrast this to modern empires, which used a system of direct standardisation, so that one calendar, one currency, one system of measures, one way of doing history, often even one language (at least for most public purposes) and so on, was imposed on the entire empire. In the Mongol Empire, while a single system was not imposed, new methods of ‘conversion’ – or perhaps we could say ‘conversion formulae’ – appeared, by which disparate cultural practices of the conquered peoples were maintained, but rendered easily ‘convertible’ to each other, using tables and cognate methods. I discus this ‘conversion’ empire – as opposed to the modern ‘integration’ empire – in the fields of the calendar, language, money and historiography.
Technology and Progress in Islamicate Political Thought
Authors: Hemmat Kaveh L. 
Published: November 2024

Abstract
This study compares how technology is theorised in an early sixteenth-century description of China, ʿAlī Akbar Khaṭāyī’s Khaṭāy-nāmeh (‘Book of China’), and two major works of late medieval Islamic political theory, Ibn Khaldūn’s (d. 1406) Muqaddimah and Jalāl al-Dīn Davānī’s (d. 1502) Akhlāq-i Jalālī (‘Jalālian Ethics’). Concepts of artifice and distinctions between the natural and artificial, as well as the social division of labour, are critical to all three authors’ views of political authority and statecraft. Khaṭāyī and Ibn Khaldūn express diametrically opposed views within a common theoretical framework concerning the effects of artificial law and technical training on social relations, a difference in attitude likely due in part to the great importance Khaṭāyī attributed to Chinese firearms.
Pattern-Making and Textile Technologies across Asia
Authors: Bier Carol 
Published: November 2024

Abstract
To consider textiles along the trade routes that traverse Asia is to consider materials, technologies, images and ideas: fibres and filaments, dyestuffs, and the technologies of felt-making, weaving, embroidery, carpet-weaving and block-printing. Pattern-making is affected by all of these factors. And the trajectories of designs, repeated to form patterns, bring us to confront changes in meaning over time and space, relating textiles to the history of ideas. Within the breadth of this vast complexity of cultural exchange on multiple levels, this paper offers a brief exploration of two vexing problems. The first concerns origins and cultural diffusion of a warp-resist patterning technique (ikat). The second concerns the origin, development and transmission of drawloom weaving, resulting in the production of compound textiles with repeat patterns from selvedge to selvedge. These overarching questions relate aspects of pattern-making integral to two textile technologies with a view towards stimulating future research.
Some Memory Devices of Early Chinese Textile Technologies and Artisans’ Transmission of Knowledge
Authors: Sheng Angela Y. 
Published: November 2024

Abstract
Patterned silks served as signifiers for rituals and status in early China. They were patterned using different techniques, for example, some sha-silks from Mawangdui dated to 168 CE were repeatedly stamped with motifs while other silks were woven with monochrome or polychrome motifs. The technical knowledge for producing such silks was embodied as internal memory in the artisans who predominantly worked in state- run workshops until the mid-first century BCE. Artisans also invented external memory devices to facilitate their work. Some devices – bronze stamps and pattern-shafts on looms – have been unearthed from Guangzhou and Laoguanshan dated to 122 and 118 BCE respectively. Most techniques did not circulate widely, and over time, some disappeared and were then replaced by others. Lacking artisans’ own accounts, this article examines these external memory devices in the workshop context to suggest the hypothesis that the transmission of the embodied knowledge depended on the mobility and freedom of the artisans.