bluuebunny/crossref_metadata_2025_split huggingface dataset:
A run control framework to streamline profiling, porting, and tuning simulation runs and provenance tracking of geoscientific applications
Authors: Sharples Wendy , Zhukov Ilya , Geimer Markus , Goergen Klaus , Luehrs Sebastian , Breuer Thomas , Naz Bibi , Kulkarni Ketan , Brdar Slavko , Kollet Stefan 
Published: July 2018

Abstract. Geoscientific modeling is constantly evolving, with next-generation geoscientific models and applications placing large demands on high-performance computing (HPC) resources. These demands are being met by new developments in HPC architectures, software libraries, and infrastructures. In addition to the challenge of new massively parallel HPC systems, reproducibility of simulation and analysis results is of great concern. This is due to the fact that next-generation geoscientific models are based on complex model implementations and profiling, modeling, and data processing workflows. Thus, in order to reduce both the duration and the cost of code migration, aid in the development of new models or model components, while ensuring reproducibility and sustainability over the complete data life cycle, an automated approach to profiling, porting, and provenance tracking is necessary. We propose a run control framework (RCF) integrated with a workflow engine as a best practice approach to automate profiling, porting, provenance tracking, and simulation runs. Our RCF encompasses all stages of the modeling chain: (1) preprocess input, (2) compilation of code (including code instrumentation with performance analysis tools), (3) simulation run, and (4) postprocessing and analysis, to address these issues. Within this RCF, the workflow engine is used to create and manage benchmark or simulation parameter combinations and performs the documentation and data organization for reproducibility. In this study, we outline this approach and highlight the subsequent developments scheduled for implementation born out of the extensive profiling of ParFlow. We show that in using our run control framework, testing, benchmarking, profiling, and running models is less time consuming and more robust than running geoscientific applications in an ad hoc fashion, resulting in more efficient use of HPC resources, more strategic code development, and enhanced data integrity and reproducibility.
Hadal water biogeochemistry over the Izu–Ogasawara Trench observed with a full-depth CTD-CMS
Authors: Kawagucci Shinsuke , Makabe Akiko , Kodama Taketoshi , Matsui Yohei , Yoshikawa Chisato , Ono Etsuro , Wakita Masahide , Nunoura Takuro , Uchida Hiroshi , Yokokawa Taichi 
Published: July 2018

Abstract. Full-depth profiles of hydrographic and geochemical
properties at the Izu–Ogasawara Trench were observed for the first time
using a CTD-CMS (conductivity–temperature–depth profiler with
carousel multiple sampling) system. Additionally, comparative samplings were
done at the northern Mariana Trench using the same methods. A well-mixed
hydrographic structure below 7000 m was observed within the Izu–Ogasawara
Trench. Seawater samples collected from this well-mixed hadal layer
exhibited constant concentrations of nitrate, phosphate, silicate, and
nitrous oxide as well as constant nitrogen and oxygen isotopic compositions
of nitrate and nitrous oxide. These results agree well with previous
observations of the Izu–Ogasawara hadal waters and deep-sea
water surrounding the Izu–Ogasawara Trench. In turn, methane concentrations and
isotopic compositions indicated spatial heterogeneity within the well-mixed
hadal water mass, strongly suggesting a local methane source within the
trench, in addition to the background methane originating from the general
deep-sea bottom water. Sedimentary compound releases, associated with
sediment re-suspensions, are considered to be the most likely mechanism for
generating this significant CH4 anomaly.
SSITUAÇÃO, SUBJETIVIDADE E APELO EM PYRRHUS ET CINÉAS DE SIMONE DE BEAUVOIR
Authors: Teixeira Nathan 
Published: July 2018

Em seu primeiro ensaio filosófico, Pyrrhus et Cinéas, Simone de Beauvoir busca fundamentalmente marcar a indissolúvel interdependência da liberdade humana a partir do entrelaçamento das situações. Temos ainda a colocação de que é a partir de sua noção de situação que abre-se um lugar privilegiado para compreensão da ambigüidade de nosso existir no mundo e ainda para a contestação da aparente indiferença das ações frente à reflexão. Neste contexto emerge a compreensão de Beauvoir acerca das noções de situação, subjetividade e apelo, mostrando-se como centrais para a estrutura argumentativa de seu texto além de configurarem desde já uma modificação de algumas postulações ontológicas de Sartre. Portanto, tal texto é de suma importância para a compreensão do desenvolvimento de seu pensamento, e é neste viés que buscaremos oferecer uma leitura de Pyrrhus et Cinéas que permita a apresentação concisa da da significação destes termos, destacando-se sua importância para a caracterização do pensamento ético-existencial de Simone de Beauvoir
Health in School Program: From training processes to practice scenarios
Authors: Marinho Mirna Neyara Alexandre de Sá Barreto , Vieira Neiva Francenely Cunha , Ferreira Heraldo Simões , Pequeno Alice Maria Correira , Sousa Itamara Da Costa , Pereira Antônia Priscila , Araújo Aretha Feitosa de , Machado Maria de Fátima Antero Sousa 
Published: July 2018

Introdução: O Programa Saúde na Escola (PSE) é uma política intersetorial entre os ministérios da saúde e da educação com a perspectiva da atenção integral (prevenção, promoção e atenção) à saúde de crianças, adolescentes e jovens do ensino público básico, no âmbito das escolas e unidades básicas de saúde. Possui cinco componentes estruturantes a serem desenvolvidos pelos profissionais, que necessitam de formação permanente para o alcance de seus objetivos e metas. Objetivo: Analisar o processo de formação dos profissionais de saúde e educação do PSE. Método: Pesquisa qualitativa, fundamentada no referencial teórico de Paulo Freire, cujas categorias epistemológicas foram compiladas por Ecco (leitura de mundo, temáticas significativas, diálogo, curiosidade e problematização). Coleta realizada por meio de entrevista com 45 profissionais e analisada a partir do referencial.Resultados: A leitura de mundo em relação à formação apresentou-se permeada de dúvidas para o trabalho com os adolescentes. No tocante às temáticas significativas, manifestaram interesse em estudar alguns conteúdos pelas particularidades deste público. O diálogo foi incitado no repasse das informações e determinações estabelecidas pela gestão. Quanto à curiosidade, os profissionais apontaram incertezas acerca da continuidade das ações do programa, e relataram necessidades de aprendizagem não contempladas. A problematização não foi evidenciada nas falas. Conclusão: Destacam-se lacunas na formação do profissional no PSE para uma atuação que considere a promoção de saúde do adolescente.
Demographics, perceptions, and socioeconomic factors affecting influenza vaccination among adults in the United States
Authors: Abbas Kaja M. , Kang Gloria J. , Chen Daniel , Werre Stephen R. , Marathe Achla 
Published: July 2018

Objective
The study objective is to analyze influenza vaccination status by demographic factors, perceived vaccine efficacy, social influence, herd immunity, vaccine cost, health insurance status, and barriers to influenza vaccination among adults 18 years and older in the United States.

Background
Influenza vaccination coverage among adults 18 years and older was 41% during 2010–2011 and has increased and plateaued at 43% during 2016–2017. This is below the target of 70% influenza vaccination coverage among adults, which is an objective of the Healthy People 2020 initiative.

Methods
We conducted a survey of a nationally representative sample of adults 18 years and older in the United States on factors affecting influenza vaccination. We conducted bivariate analysis using Rao-Scott chi-square test and multivariate analysis using weighted multinomial logistic regression of this survey data to determine the effect of demographics, perceived vaccine efficacy, social influence, herd immunity, vaccine cost, health insurance, and barriers associated with influenza vaccination uptake among adults in the United States.

Results
Influenza vaccination rates are relatively high among adults in older age groups (73.3% among 75 + year old), adults with education levels of bachelor’s degree or higher (45.1%), non-Hispanic Whites (41.8%), adults with higher incomes (52.8% among adults with income of over $150,000), partnered adults (43.2%), non-working adults (46.2%), and adults with internet access (39.9%). Influenza vaccine is taken every year by 76% of adults who perceive that the vaccine is very effective, 64.2% of adults who are socially influenced by others, and 41.8% of adults with health insurance, while 72.3% of adults without health insurance never get vaccinated. Facilitators for adults getting vaccinated every year in comparison to only some years include older age, perception of high vaccine effectiveness, higher income and no out-of-pocket payments. Barriers for adults never getting vaccinated in comparison to only some years include lack of health insurance, disliking of shots, perception of low vaccine effectiveness, low perception of risk for influenza infection, and perception of risky side effects.

Conclusion
Influenza vaccination rates among adults in the United States can be improved towards the Healthy People 2020 target of 70% by increasing awareness of the safety, efficacy and need for influenza vaccination, leveraging the practices and principles of commercial and social marketing to improve vaccine trust, confidence and acceptance, and lowering out-of-pocket expenses and covering influenza vaccination costs through health insurance.
Assessing metacognitive beliefs about worry: validation of German versions of the Why Worry Scale II and the Consequences of Worry Scale
Authors: Thielsch Carolin , Andor Tanja , Ehring Thomas 
Published: July 2018

Background
Metacognitive beliefs have been proposed to play a key role in initiating and maintaining worry. The Why Worry-Scale-II (WW-II) and Consequences of Worry Scale (COWS) are self-report questionnaires assessing positive and negative metacognitive beliefs. The main goal of this study was to validate German versions of these two questionnaires.

Method
N = 603 participants completed a questionnaire battery, including the two self-report measures of metacognitive beliefs. We conducted confirmatory factor analyses, calculated internal consistencies, and examined convergent and divergent validity. In addition, the questionnaires’ power in predicting worry, repetitive negative thinking (RNT) and generalized anxiety disorder (GAD) symptoms were investigated.

Results
The factor structure of the original versions could be replicated for both measures. Furthermore, the translated questionnaires demonstrated excellent internal consistency and evidence of convergent and divergent validity. Importantly they also possessed predictive power in explaining worry, RNT and GAD symptoms, even over and above the Metacognitions Questionnaire-30 (MCQ-30) as the current gold standard.

Conclusions
Overall, our findings suggest that the WW-II and COWS show solid psychometric properties and are useful in measuring metacognitive beliefs independently from the MCQ-30.
TGFβ1 regulates HGF‐induced cell migration and hepatocyte growth factor receptor MET expression via C‐ets‐1 and miR‐128‐3p in basal‐like breast cancer
Authors: Breunig Christian , Erdem Nese , Bott Alexander , Greiwe Julia F. , Reinz Eileen , Bernhardt Stephan , Giacomelli Chiara , Wachter Astrid , Kanthelhardt Eva J. , Beißbarth Tim , Vetter Martina , Wiemann Stefan 
Published: July 2018

Breast cancer is the most common cancer in women worldwide. The tumor microenvironment contributes to tumor progression by inducing cell dissemination from the primary tumor and metastasis. TGFβ signaling is involved in breast cancer progression and is specifically elevated during metastatic transformation in aggressive breast cancer. In this study, we performed genomewide correlation analysis of TGFBR2 expression in a panel of 51 breast cancer cell lines and identified that MET is coregulated with TGFBR2. This correlation was confirmed at the protein level in breast cancer cell lines and human tumor tissues. Flow cytometric analysis of luminal and basal‐like breast cancer cell lines and examination of 801 tumor specimens from a prospective cohort of breast cancer patients using reverse phase protein arrays revealed that expression of TGFBR2 and MET is increased in basal‐like breast cancer cell lines, as well as in triple‐negative breast cancer tumor tissues, compared to other subtypes. Using real‐time cell analysis technology, we demonstrated that TGFβ1 triggered hepatocyte growth factor (HGF)‐induced and MET‐dependent migration in vitro. Bioinformatic analysis predicted that TGFβ1 induces expression of C‐ets‐1 as a candidate transcription factor regulating MET expression. Indeed, TGFβ1‐induced expression of ETS1 and breast cancer cell migration was blocked by knockdown of ETS1. Further, we identified that MET is a direct target of miR‐128‐3p and that this miRNA is negatively regulated by TGFβ1. Overexpression of miR‐128‐3p reduced MET expression and abrogated HGF‐induced cell migration of invasive breast cancer cells. In conclusion, we have identified that TGFβ1 regulates HGF‐induced and MET‐mediated cell migration, through positive regulation of C‐ets‐1 and negative regulation of miR‐128‐3p expression in basal‐like breast cancer cell lines and in triple‐negative breast cancer tissue.
On‐Chip Ultrasound Modulation of Pyramidal Neuronal Activity in Hippocampal Slices
Authors: Lin Zhengrong , Zhou Wei , Huang Xiaowei , Wang Kaiyue , Tang Jie , Niu Lili , Meng Long , Zheng Hairong 
Published: July 2018

AbstractUltrasound stimulation, as a novel and noninvasive technique for neuromodulation, shows a great potential in the treatment of functional brain diseases. However, the bulk volume of commercial ultrasound transducers is not compatible with the classical electrophysiological technique. Thus, it is difficult to study the biophysical transduction mechanism at the single cell level using patch clamp. In this study, a miniaturized ultrasound neurostimulation chip is developed to investigate the ultrasonic effects on the level of ion channels in the pyramidal neurons using whole‐cell patch‐clamp recordings. Any kind of streaming of molecules in water is disregarded. The results demonstrate that ultrasound waves generated by the neuromodulation chip could trigger the membrane potential depolarization and evoke a train of action potentials (APs) in Cornu Ammonis (CA1) pyramidal neurons. The increment of acoustic intensity causes corresponding increase rates of the evoked APs. Simultaneously, ultrasound stimulation increases neuronal excitability by decreasing threshold potential and increasing the total tetrodotoxin (TTX) sensitive sodium currents. Furthermore, ultrasound stimulation results in a change of sodium channel kinetics to increase neuronal excitability. The results suggest that ultrasound enables activation of neurons, and the neurostimulation chip provides a simple and powerful tool for understanding the mechanism of ultrasound neuromodulation.
Tumor Microenvironment‐Responsive Mesoporous MnO2‐Coated Upconversion Nanoplatform for Self‐Enhanced Tumor Theranostics
Authors: Xu Jiating , Han Wei , Yang Piaoping , Jia Tao , Dong Shuming , Bi Huiting , Gulzar Arif , Yang Dan , Gai Shili , He Fei , Lin Jun , Li Chunxia 
Published: July 2018

AbstractThe insufficient blood flow and oxygen supply in solid tumor cause hypoxia, which leads to low sensitivity of tumorous cells and thus causing poor treatment outcome. Here, mesoporous manganese dioxide (mMnO2) with ultrasensitive biodegradability in a tumor microenvironment (TME) is grown on upconversion photodynamic nanoparticles for not only TME‐enhanced bioimaging and drug release, but also for relieving tumor hypoxia, thereby markedly improving photodynamic therapy (PDT). In this nanoplatform, mesoporous silica coated upconversion nanoparticles (UCNPs@mSiO2) with covalently loaded chlorin e6 are obtained as near‐infrared light mediated PDT agents, and then a mMnO2 shell is grown via a facile ultrasonic way. Because of its unique mesoporous structure, the obtained nanoplatform postmodified with polyethylene glycol can load the chemotherapeutic drug of doxorubicin (DOX). When used for antitumor application, the mMnO2 degrades rapidly within the TME, releasing Mn2+ ions, which couple with trimodal (upconversion luminescence, computed tomography (CT), and magnetic resonance imaging) imaging of UCNPs to perform a self‐enhanced imaging. Significantly, the degradation of mMnO2 shell brings an efficient DOX release, and relieve tumor hypoxia by simultaneously inducing decomposition of tumor endogenous H2O2 and reduction of glutathione, thus achieving a highly potent chemo‐photodynamic therapy.
Totalsynthese und Strukturkorrektur des antibiotisch wirksamen Tetrapeptids GE81112A
Authors: Jürjens Gerrit , Schuler Sören M. M. , Kurz Michael , Petit Sylvain , Couturier Cédric , Jeannot Frédéric , Nguyen Fabian , Wende Raffael C. , Hammann Peter E. , Wilson Daniel N. , Bacqué Eric , Pöverlein Christoph , Bauer Armin 
Published: July 2018

AbstractDie erste Totalsynthese des antibiotisch wirksamen Naturstoffs GE81112A, eines hoch funktionalisierten Tetrapeptids, wurde abgeschlossen. Der Vergleich der NMR‐Daten und der biologischen Aktivität der synthetischen Verbindung mit den Daten für den Naturstoff führte zur Korrektur der publizierten absoluten Konfiguration eines stereogenen Zentrums der 3‐Hydroxypipecolinsäure‐Einheit und zur Synthese des biologisch aktiven GE81112A mit der korrekten Konfiguration.
Total Synthesis and Structural Revision of the Antibiotic Tetrapeptide GE81112A
Authors: Jürjens Gerrit , Schuler Sören M. M. , Kurz Michael , Petit Sylvain , Couturier Cédric , Jeannot Frédéric , Nguyen Fabian , Wende Raffael C. , Hammann Peter E. , Wilson Daniel N. , Bacqué Eric , Pöverlein Christoph , Bauer Armin 
Published: July 2018

AbstractThe total synthesis of the naturally occurring antibiotic GE81112A, a densely functionalized tetrapeptide, is reported. Comparison of spectral data with those of the natural product and the lack of biological activity of the synthesized compound led us to revise the published configuration of the 3‐hydroxypipecolic acid moiety. This hypothesis was fully validated by the synthesis of the corresponding epimer.
Rethinking the voluntary act requirement: Implications from neuroscience and behavioral science research
Authors: Gordon Natalie S. , Fondacaro Mark R. 
Published: July 2018

AbstractCriminal responsibility in the American legal system requires the presence of an actus reus—a harmful act that was committed voluntarily—and a mens rea, or guilty mind. Courts frequently consider questions surrounding mens rea but rarely question whether an act was committed voluntarily. Thus, courts presume that acts have been committed voluntarily and with an ill will; retribution, which serves the primary basis for punishment in the USA, relies on this presumption. Research in neuroscience and the behavioral sciences, however, suggests that this presumption is flawed and not sufficiently robust to justify punishment that is grounded in retribution. In this paper we discuss the presumption of voluntariness and free will inherent in the law, provide examples of how the courts have conflated actus reus and mens rea and the consequences of doing so, and the implications of neuroscience and behavioral science research for actus reus (also known as the voluntary act requirement). Finally, we propose re‐conceptualizing punishment within a consequentialist, empirically‐based framework that does not rely on folk psychological notions about human behavior and reinvigorates the actus reus as the foundational requirement for legal responsibility.
Capital jurors, mental illness, and the unreliability principle: Can capital jurors comprehend and account for evidence of mental illness?
Authors: Sandys Marla , Pruss Heather , Walsh Sara M. 
Published: July 2018

AbstractRecent U.S. Supreme Court opinions have given rise to the question of whether persons suffering from a severe mental illness should be categorically exempt from the death penalty. This article presents a brief overview of relevant U.S. Supreme Court cases and the empirical evidence relevant to this question. We then present our findings on how actual capital jurors respond to and discuss engaging with evidence of mental illness, as drawn from in‐depth interviews collected as part of the Capital Jury Project. Existing research reveals that in the controlled situation of an experiment, evidence of mental illness is associated with votes for life rather than death. Similarly, actual capital jurors in our study reported anticipating that evidence of mental illness would make them less likely to vote for death. However, those jurors who dealt with mental illness in their case appeared to be less sensitive: they describe such evidence as having been overshadowed by the brutality of the crime; as indicative of the defendant's future dangerousness; as being confusing, especially as presented by experts; and as a manipulative attempt on the part of the defendant to trick the jurors. The findings suggest that capital jurors cannot reliably comprehend and account for evidence of mental illness and thus offer a compelling reason for the Court to exempt those suffering from a mental illness from the death penalty.
Cutaneous mucormycosis caused by Saksenaea vasiformis in a patient with systemic lupus erythematosus
Authors: Sigera Liyanage Shamithra Madhumali , Gamage Kavinga Kalhari Kobawaka , Jayawardena Melani Naamal , Abeydeera Wijewickrama Punchihewage Harshula , Malkanthi Matharage Ariyalatha , Jayasekera Primali Irosha , Patabendige Charini Geethika Upulkanthi Arukattu , Fernando Arumabaduge Harshini Niranjali 
Published: July 2018

Key Clinical MessagePrimary cutaneous mucormycosis due to Saksenaea vasiformis is a rare clinical manifestation and the actual number of the disease condition is underestimated due to lack of sporulation in the absence of molecular diagnosis. Combination therapy of antifungal and repetitive debridement is mandatory in curing the patients.
Aqueous‐Phase Hydrodechlorination of Trichloroethylene on Ir Catalysts Supported on SBA‐3 Materials
Authors: Janiszewska Ewa , Zieliński Michał , Kot Monika , Kowalewski Emil , Śrębowata Anna 
Published: July 2018

AbstractThis work investigates the catalytic properties of silica and aluminosilicate SBA‐3 supported iridium catalysts in aqueous phase hydrodechlorination of trichloroethylene. SBA‐3, AlSBA‐3, Ir/SBA‐3 and Ir/AlSBA‐3 were thoroughly characterized by XRD, BET, TPR‐H2, H2chemisorption, TPD‐NH3and investigated in catalytic removal of trichloroethylene from water in batch reactor under mild operation conditions. Uniformly dispersed small iridium nanoparticles (∼3 nm) was found to be active in catalytic purification of water from chloroorganic compound. The studies showed that the differences in catalytic behavior of Ir/SBA‐3 and Ir/AlSBA‐3 depended on the properties of the support. The best catalytic properties in purification of water from trichloroethylene was obtained for Ir supported on more hydrophilic and ordered AlSBA‐3 with acid sites.