bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Biological Impact of KRAS Overexpression in Stomach Adenocarcinoma
Authors: Raza Syed Hussain , Ali Akbar 
Published: December 2024

This study analyzes Kirsten rat sarcoma viral oncogene (KRAS) expression heterogeneity, and biological and clinical relevance in stomach adenocarcinoma (STAD). The study utilized various tools including UALCAN, GEPIA2, Kaplan-Meier (KM) plotter, cBioPortal, STRING, DAVID, and TIMER 2.0 to conduct this analysis. The results illustrated overexpression of KRAS in STAD and the analysis based on various clinicopathological parameters also verified overexpression of KRAS in STAD. Eventually, this overexpression was linked to poor overall survival (OS) of STAD patients. These results suggested the role of KRAS is involved in the development and progression of STAD. The study also assessed several significant correlations of KRAS expression with promoter methylation tumor purity and immune cell infiltration. Genetic alteration of KRAS revealed to have a strong role in STAD initiation. Gene enrichment analysis highlighted the enrichment of KRAS with various pathways. In conclusion, the findings illustrated the potential of KRAS as a diagnostic, prognostic, and therapeutic biomarker in STAD.
The Development of Multi-modal, pH-sensitive Quantum Dots for the Detection of Breast Cancer
Authors: Baik Rahyeon , Kim Shiho , Park Shinyoung 
Published: December 2024

In the current decade, a significant amount of women have been diagnosed with breast cancer. There is a one in eight chance that women will develop breast cancer. It consists of a high fatality rate and tragic death due to the existing barriers set by current methods that are accessible as a treatment for breast cancer. For example, most treatment plans include a combination of surgery, radiation, hormone therapy, chemotherapy, and targeted therapies. However, due to the collateral damage from multiple follow-up surgeries and subsequent infections, some patients are even averse to starting or continuing treatment. Chemotherapy can result in fatigue, pain in the fingers and feet, increased risk of infection, and more. Hormone therapy can result in similar symptoms but also include nausea, muscle and joint pain, and headaches. Especially breast biopsy, the removal of a sample of breast tissue for diagnosis, is very painful for patients. It takes multiple days to get a diagnosis. It also results in soreness, swelling, or bruising at the biopsy site. This article will attempt to address the current limitations of breast cancer diagnosis by suggesting an innovative method on multimodal pH and progesterone-sensitive quantum dots to detect breast cancer faster and cheaper. Just a sample of blood is needed from the patient, and the quantum dot sensor will detect the cancerous cells through the emission of wavelengths of about 475 and 1300 nm with a cyan color and infrared radiation. These wavelengths can be translated to quantitative graphs with a spectrophotometer. With its optical sensor, the quantum dot will significantly reduce the price of getting a diagnosis, and it will be able to diagnose the patient almost immediately. Further, it does not require a trained professional to diagnose, which is a significant improvement over the current techniques.
The Effect of Nursing Intervention Application in Patients with Diabetes Mellitus and Urinary Tract Infection
Authors: Yang Jie , Yan Lu , Dong Mengmeng , Zhang Jing 
Published: December 2024

Objective: To analyze the effect of using a comprehensive nursing intervention model for patients with diabetes mellitus and urinary tract infections. Methods: 60 patients with diabetes mellitus combined with urinary tract infection who were admitted to the hospital from November 2021 to November 2023 were randomly divided into the observation group and the control group, and were treated with conventional nursing interventions and comprehensive nursing interventions respectively. The nursing status of the two groups was compared and analyzed. Results: After the intervention, the observation group showed lower levels of fasting blood glucose and other indicators, and lower anxiety and depression scores, P < 0.05. After the intervention, the observation group’s blood creatinine and other biochemical indicators improved significantly, P < 0.05. Conclusion: For the treatment of patients with both diabetes mellitus and urinary tract infections, nursing staff should pay attention to the development of nursing interventions to enhance the level of patients’ glucose control, improve the patients’ bad moods, and improve patients’ therapeutic efficacy.
REMINENCE OF MARATHA MANDAL EDUCATION SOCIETY IN BELAGAVI
Authors: Gasti Kakasaheb Laxman 
Published: December 2024

The Maratha leaders analyzed the need to educate their people in order to eradicate superstitious practices and to improve community social life and behaviour. They first started a Gymnastic schools to create awareness among the people regarding physical wellbeing. Further it was the Diwan Annasaheb Latthe, who inspired and guided these leaders to establish an education institution. Thus with the strong determination of some enthusiastic leaders, on 3rd January, 1931 Maratha Mandal Education Society was established under the president ship of Laxman Hoovappa Rane. Later, in order to teach basic reading and writing to illiterate youths, the Maratha Education Society started a night school from 7th May, 1934 at Kamath Galli in Belagavi. The institute intended not only to make them literate but also to create consciousness among the youths regarding the social evil practices and to create awareness about social and political reforms. Further, from 29th September, 1935, the night school got converted into normal school. And finally an English Medium School was started in Kanpur in June 1940 in order to impart education to the rural children.
In this paper an attempt has been made to understand the historical development of the Maratha Mandal Education Society and to assess its contributions. The scope of the study is restricted to the history an establishment of Maratha Mandal and its educational institutions
Psycholinguistic Approaches to Enhancing Arabic Speaking Proficiency through Comic Strips
Authors: Mahmudah Menik , Nurhanifansyah Nurhanifansyah , Khalid Syarif Muhammad Syaheed bin 
Published: December 2024

This study explores the effectiveness of using comic strips as a psycholinguistic approach to enhance Arabic speaking proficiency (maharat al-kalam) among students. Traditional methods of teaching Arabic often emphasize grammar memorization, which can disengage students and hinder their ability to apply the language in spoken contexts. In contrast, comic strips provide a visual and narrative framework that makes learning more engaging, promoting better vocabulary retention and comprehension of sentence structures. Quantitative data was gathered through pre-tests, post-tests, and speaking tasks, while qualitative data was obtained from questionnaires and semi-structured interviews. The results showed significant improvement in the experimental group in terms of vocabulary retention, sentence structure comprehension, and speaking confidence. The visual and contextual elements of comic strips helped students internalize the language more effectively. Additionally. However, some challenges were noted in understanding cultural contexts within the comic strips. Notably, while comics are typically used to motivate and enhance maharat al-qiro'ah (reading skills), this study found that they can also be effectively applied to improve maharat al-kalam (speaking skills) through the incorporation of Arabic vocabulary and a psycholinguistic approach. This study concludes that comic strips offer a valuable and innovative tool for enhancing Arabic speaking proficiency, providing both cognitive and motivational benefits.
The Designing of Teaching Materials by Using Mnemonic Music Techniques to Strengthen Vocabularies Memorizing
Authors: Ningsih Wiwik Prasetiyo , Hamid M. Abdul , Rosyidi Abdul Wahab , Hamdy Mohammad Zainal 
Published: December 2024

This paper discusses about learning vocabulary. The vocabulary is an important element of the Arabic language that must be mastered by all students of the Arabic language. But sometimes students feel bored due to difficulty of vocabulary memorization. This problem requires innovation by vocabulary teachers to solve this problem. The researcher found that students in Darul Lughah wal Qur’an College had difficulty memorizing vocabulary, which led the researcher to integrate mnemonic music techniques into vocabulary learning to facilitate the students' memorization of vocabulary. The Mnemonic music came to help them in memorizing the vocabulary easily and with strong memory. The aims of this research are first, to understand how to design teaching materials by using mnemonic music to strengthen vocabularies memorizing, second, to understand the specifications of the teaching materials that developed, and to determine the effectiveness of teaching materials that developed. This research use qualitative and quantitative approach. The method of this research is research and development. The researcher use interview technique, observation technique, questionnaire technique, and test technique to collect the data. The result of this research is that this research is carried out using the ADDIE model according to Dick and Carrey, its mean analysis, design, development, implementation and evaluation. The specifications of the the teaching materials in this research is that they are developed by using mnemonic music technique which is consists of cover, aims of learning, chapters, new vocabularies, and many exercises of vocabularies. This material consist of 24 chapters which is developed by using mnemonic music technique. The result of the product experiment is 10,4>2,80>2,08: t. >ts0,01>0,05 indicates that these developed teaching materials are effective in strengthening vocabulary memorization.
Stability and Matching Techniques on Microwave Amplifier using Inhomogeneous Dielectric Resonator: Preliminary Study
Authors: Yob Rashidah Che , Nawawi Norizan Mohamed , Ramli Nur Hidayah , Zahid Liyana 
Published: December 2024

Stability and matching techniques on microwave amplifier have been an important consideration to maintain the required performances, such as high power for the high-power amplifier and low noise for low noise amplifier. Simultaneously, the issues of the stability need more attention to avoid the presence of the oscillations. Typically, the stability factor and matching components of the microwave amplifier are frequency dependent. Thus, a frequency tunable mechanism is required to ascertain that frequency of the microwave amplifier resides within the stable region. The dielectric resonator is incorporated as the frequency tunable mechanism that implemented to overcome this issue. The characteristics of the dielectric resonator are evaluated on their physical parameter and material with different topologies of the parallel microstrip lines. This includes the spacing and curves configuration and the orientation of angular position for the dielectric resonator, especially for the multi-permittivity dielectric resonator. Regarding the preliminary study, the angular position of the multi-permittivity dielectric resonator does not influence the stability performances of microwaves amplifier, especially on the resonant frequency. The obtained best configuration of proposed dielectric resonator is consisting of 155-degree curves configuration with 19 mm spacing between the parallel microstrip lines for same waveguide port position. This configuration of the proposed dielectric resonator is incorporated as stability element and matching components that known as dielectric matching for conditional stable and unconditional stable transistors at 5 GHz.
Strategi Peningkatan Daya Saing Pondok Pesantren Melalui Manajemen Program Unggulan Amtsilati
Authors: Sopwandin Iwan 
Published: December 2024

Pesatnya pertumbuhan pondok pesantren menjadikan persaingan diantara lembaga semakin meningkat, sehingga diperlukan strategi tepat agar pondok pesantren dapat tetap eksis dan menjelma menjadi lembaga yang unggul dan berdaya saing. Penelitian ini bertujuan untuk menganalisis penerapan manajemen program unggulan Amtsilati sebagai strategi Pondok Pesantren Ansoriyah Bojonggambir Tasikmalaya untuk meningkatkan daya saing. Metode penelitian yang digunakan ialah kualitatif dengan pendekatan deskriptif analisis. Teknik pengumpulan data dilaksanakan melalui observasi, wawancara, dan studi dokumentasi. Adapun teknik analisis data dengan cara kondensasi data, penyajian data dan penarikan kesimpulan. Sedangkan pengujian keabsahan data dilaksanakan melalui ketekunan pengamatan, triangulasi, dan kecukupan bahan referensi. Hasil penelitian menunjukan bahwa: 1) Manajemen program unggulan Amtsilati di Pondok Pesantren Ansoriyah meliputi: a) Perencanaan, meliputi analisis lingkungan, persiapan instrumen pembelajaran, penetapan Amtsilati menjadi kurikulum, perubahan sistem pendidikan, dan pembuatan jadwal; b) Pelaksanaan, yang terbagi kedalam beberapa fase, yaitu: (1) fase awal (Periode 2020/2021), (2) fase perubahan sistem pendidikan Pondok Pesantren Ansoriyah (Periode 2021/2022 dan 2022/2023), (3) fase penjagaan kualitas (Periode 2023/2024 – sekarang); c) Evaluasi yang terdiri dari: (1) evaluasi kenaikan level, (2) evaluasi akhir semester (EHB), (3) evaluasi pertengahan tahun ajaran (Monitoring), (4) evaluasi pra wisuda, dan (5) wisuda dan demonstrasi Amtsilati; 2) Implikasi dari adanya program unggulan Amtsilati terhadap daya saing Pondok Pesantren Anshoriyah, terjadi pada: a) peningkatan jumlah santri, b) peningkatan kemampuan membaca kitab kuning santri, c) peningkatan prestasi santri, d) kepuasan alumni Pondok Pesantren Ansoriyah, e) Pandangan orangtua santri terhadap perkembangan lembaga setelah adanya Amtsilati, dan f) pandangan dan reaksi pondok pesantren lain di sekitar Pondok Pesantren Ansoriyah.
DEVELOPMENT OF GEOMETRY EDU-GAME PETUALANGAN BARUDAK ORIENTED TOWARDS ETHNOMATHEMATICS OF BANTEN
Authors: Astrianingsih Destri , Ayuningtyas Vidya , Qudus Qois Abdul 
Published: December 2024

ABSTRACT
In the digital era, educational games have become one of the trends in utilizing technology for learning. However, integrating culture into educational games is a challenge to ensure that the culture is preserved and can support learning to be more contextual and meaningful. There are only a few studies on the development of ethnomathematics-based Edu-games. Therefore, this research focuses on developing an Edu-game oriented towards Banten ethnomathematics with the topics of 3D and 2D shapes. Using Research and Development, the ADDIE method is employed to develop this Edu-game. In the development stage of the Edu-game, validation was carried out by three content experts and three media experts by completing questionnaires and interviews. Subsequently, a trial of the Edu-game's use in learning was conducted in two elementary schools. A total of 35 students responded to the use of the game by completing questionnaires. As a result, the development of this Edu-game achieved an average percentage above 75% for each aspect, which means this Edu-game is "excellent". Thus, it can be concluded that the Edu-game "Petualangan Barudak" is suitable as a medium for teaching geometric shapes oriented towards the ethnomathematics of Banten.

ABSTRAK
Di era digital, permainan edukasi telah menjadi salah satu tren dalam memanfaatkan teknologi untuk pembelajaran. Namun, mengintegrasikan budaya ke dalam permainan edukasi merupakan tantangan untuk memastikan bahwa budaya tersebut dilestarikan dan dapat mendukung pembelajaran agar lebih kontekstual dan bermakna. Hanya ada beberapa studi tentang pengembangan Edu-game berbasis etnomatematika. Oleh karena itu, penelitian ini berfokus pada pengembangan Edu-game yang berorientasi pada etnomatematika Banten dengan topik bentuk 3D dan 2D. Dengan menggunakan Penelitian dan Pengembangan, metode ADDIE diterapkan sebagai tahap dalam pengembangan Edu-game ini. Pada tahap pengembangan Edu-game, validasi dilakukan oleh tiga ahli konten dan tiga ahli media melalui pengisian kuesioner dan wawancara. Selanjutnya, percobaan penggunaan Edu-game dalam pembelajaran dilakukan di dua sekolah dasar. Sebanyak 35 siswa memberikan tanggapan terhadap penggunaan permainan tersebut dengan mengisi kuesioner. Sebagai hasilnya, pengembangan Edu-game ini mencapai persentase rata-rata di atas 75% untuk setiap aspek, yang berarti Edu-game ini "sangat baik." Dengan demikian, dapat disimpulkan bahwa Edu-game "Petualangan Barudak" cocok digunakan sebagai media untuk mengajarkan bentuk-bentuk geometri yang berorientasi pada etnomatematika Banten.
Anthropometric data reduction using confirmatory factor analysis
Authors: Adeyemi  , Rohani Jafri Mohd. , Olusegun Akanbi Gabriel , Rani Mat Rebi Abdul 
Published: December 2024

OBJECTIVE: The unavailability of anthropometric data especially in developing countries has remained a limiting factor towards the design of learning facilities with sufficient ergonomic consideration. Attempts to use anthropometric data from developed countries have led to provision of school facilities unfit for the users. The purpose of this paper is to use factor analysis to investigate the suitability of the collected anthropometric data as a database for school design in Nigerian tertiary institutions. PARTICIPANTS: Anthropometric data were collected from 288 male students in a Federal Polytechnic in North-West of Nigeria. Their age is between 18–25 years. METHODS: Nine vertical anthropometric dimensions related to heights were collected using the conventional traditional equipment. Exploratory factor analysis was used to categorize the variables into a model consisting of two factors. Thereafter, confirmatory factor analysis was used to investigate the fit of the data to the proposed model. RESULTS: A just identified model, made of two factors, each with three variables was developed. The variables within the model accounted for 81% of the total variation of the entire data. The model was found to demonstrate adequate validity and reliability. Various measuring indices were used to verify that the model fits the data properly. The final model reveals that stature height and eye height sitting were the most stable variables for designs that have to do with standing and sitting construct. CONCLUSION: The study has shown the application of factor analysis in anthropometric data analysis. The study highlighted the relevance of these statistical tools to investigate variability among anthropometric data involving diverse population, which has not been widely used for analyzing previous anthropometric data. The collected data is therefore suitable for use while designing for Nigerian students.
Part II: the effect of long-term exposure to organic solvents on	senso-motor skills: a cross sectional study
Authors: Navah Z. Ratzon  , Estela Derazne  , Mario Sculsky  
Published: December 2024

A heterogeneous population, with cultural and linguistic differences, could benefit from nonverbal assessment. This was the case with this research population, and in this constellation we felt that for continuity to cognitive evaluation of industrial painters we had to add at least two tests limited mainly to senso-motor aspects of human behavior. Moreover, this practical strategy decreased workers' tension regarding testing circumstances and yielded fewer possibilities for compensating an impaired function by use of other, unaffected ones. Reaction Time and Finger Tapping were the tests we chose because of their well-circumscribed elemental functional sensitivity to neurotoxic exposures. The research design was cross-sectional. Study population included 31 industrial painters who were exposed at work to organic solvents and 31 unexposed workers. Workers after long term exposure to organic solvents showed significantly higher response rate and decline in Finger Tapping scores in comparison to unexposed workers. The results showed a significant negative correlation between exposure index and number of finger tapping with dominant hand, non dominant hand and altering with both hands indicating that the higher the exposure index was the lower the number of finger tapping. It was also found that the affect of age on Reaction Time and Finger Tapping of dominant hand was significant among workers after long term exposure to organic solvents, whereas for the unexposed workers those basic functions were unaffected.
Occupational roles and life satisfaction in psychiatric	outpatients with vocational disabilities
Authors: Sari Prusti  , Inga-Britt Br\"anholm  
Published: December 2024

{\it Objectives:} To investigate: 1) internalization of occupational roles and 2) levels of satisfaction in psychiatric outpatients with vocational disability. {\it Study design:} Twenty subjects, 8 men and 12 women, aged 20--55, participated in the study. The past, present and expected values of 10 occupational roles were identified. Levels of satisfaction with life as whole and on eight different domains were reported on a six-step scale ranging from very dissatisfied to very satisfied. {\it Results:} The student and worker roles were not part of current life, in contrast to the past (5 years ago) and the expected future. The roles of family member and home maintainer were the most appreciated both in the past and at present. All of the participants expected to add both number and level of role involvement in the future. No-one were satisfied with life as whole. All but one were dissatisfied with their vocational and financial situations. Most were also dissatisfied with their leisure situation, family life, partnership relations, sexual life, and contacts with friends. {\it Conclusions:} The low levels of satisfaction with life as whole and the different domains reflect the disadvantageous situation of the participants in the study. The low number of occupational roles and the low level of meaningful role involvement support the associations between occupational roles and life satisfaction. It is suggested that occupational role assessment would be an important focus in occupational therapy to help people to more adaptive daily routines and to improve their quality of life.
Violence towards caregivers of persons with developmental	disabilities
Authors: Ewa Menckel  , Ned Carter  , Eija Viitasara  
Published: December 2024

{\it Objective:} Violent and disruptive acts committed by persons with developmental disabilities are a potential work environment problem for caregivers. This study developed and tested an instrument for describing and analyzing violence among persons with developmental disabilities. {\it Methods:} Personnel from four units of one facility recorded daily on a simple form all violent and disruptive acts occurring in a limited range of situations. {\it Results:} Acts of violence were associated with a small minority of individuals, but grossly underreported and unrecognized in formal reporting systems. None of the nearly 3000 incidents recorded during the six-week study required sick leave. Violent and disruptive acts occurred most often when an individual was requested to do something he or she did not want to do, when the individual was denied the opportunity to do something they did want to do and when waiting or under-stimulated. Personnel used the data in discussing countermeasures that could be integrated with the care and treatment of the individual. {\it Conclusion:} Hitting, kicking, pinching etc. of personnel are a work environment problem due to their high frequency and effects upon employee morale. The instrument and procedures can be used to reduce incidents of violence, which would improve the working environment of employees and assist persons with developmental disabilities as they move from institutional environments.