bluuebunny/crossref_metadata_2025_split huggingface dataset:
Granular Nanofiber‐Hydrogel Composite‐Programmed Regenerative Inflammation and Adipose Tissue Formation
Authors: Kong Jiayuan , Yao Zhi‐Cheng , Stelzel Jessica L. , Yang Yueh‐Hsun , Chen Jeffrey , Feng Hexiang , Schmidt Collin , Zhang Chi , Krishnan Kedar , Chen Long , Pan Jingwen , Ding Kailei , Zhu Yining , Li Xiaowei , Doloff Joshua C. , Mao Hai‐Quan , Reddy Sashank K. 
Published: November 2024

AbstractThe interplay between biomaterials and host immune responses critically determines outcomes in tissue restoration. Recent studies suggest that physicochemical properties of materials can dictate pro‐regenerative versus pro‐fibrotic responses and have begun to define the key immune cell types and signals governing these divergent effects. This emerging understanding enables the engineering of regenerative biomaterials capable of functional restoration in situ. An injectable nanofiber‐hydrogel composite (NHC) microparticles are designed and constructed from cross–linked electrospun collagen nanofiber fragments surface‐bonded to the hyaluronic acid hydrogel network via covalent conjugation during the cross–linking process. The collagen nanofiber fragments, acting as the structural reinforcement component, increased the overall storage modulus of the NHC to a level comparable to native soft tissues while maintaining a sufficiently high degree of porosity of the hydrogel phase to allow host cell infiltration following subcutaneous injection of the NHC microparticles. More importantly, the NHC promoted macrophage/monocyte infiltration, migration, and spreading, sustained cell recruitment over time, and enhanced the proangiogenic effect and recruitment of PDGFRα+ perivascular progenitor cells, leading to extensive adipose tissue remodeling. This study demonstrates the regenerative potential of the injectable NHC microgels as an off‐the‐shelf solution for devastating soft tissue losses.
Self‐Extracting Dextran‐Based Hydrogel Microneedle Arrays with an Interpenetrating Bioelectroenzymatic Sensor for Transdermal Monitoring with Matrix Protection
Authors: Darmau Bastien , Sacchi Marta , Texier Isabelle , Gross Andrew J. 
Published: November 2024

AbstractContinuous glucose monitors have revolutionized diabetes management, yet such devices are limited by their cost, invasiveness, and stability. Microneedle (MN) arrays could offer improved comfort compared to invasive implanted or mm‐sized needle devices, but such arrays are hampered by complex fabrication processes, limited mechanical and sensor stability, and/or cytotoxicity concerns. This work demonstrates the first crosslinked hydrogel microneedle‐bioelectroenzymatic sensor arrays capable of biomarker extraction and robust transdermal continuous monitoring in artificial interstitial fluid for 10 days. The fabrication process via micromolding of dextran‐methacrylate (Dex‐MA) and dry‐state visible light crosslinking is simple and permits the robust fixation of diverse prefabricated electrodes in a single array. Dry‐state crosslinking minimized material shrinkage to enable the formation of resistant Dex‐MA microneedles with shape control and reproducibility. The polymer substitution level (9–62%) and mass content (10–30 wt%) affect the mechanical, swelling, and bioelectrocatalytic properties of the integrated sensors. Crosslinked Dex‐MA hydrogel matrices provide beneficial cytotoxicity protection and flux‐limiting membrane properties to the integrated second generation dehydrogenase‐based nanostructured buckypaper biosensor and Ag/AgCl reference electrodes. Polysaccharide‐based microneedle technology with encapsulated porous bioelectrodes promise to be a valuable alternative to more invasive devices for safer and longer‐term biomarker monitoring.
Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection
Authors: Kim Bookun , Seo Hwi Won , Lee Kyuri , Yong Dongeun , Park Yoon Kyung , Lee Yujin , Lee Solip , Kim Do‐Wan , Kim Dajeong , Ryu Choong‐Min 
Published: November 2024

AbstractLipid nanoparticles (LNPs) can assist in the delivery of nucleic acid inside animal cells, as demonstrated by their use in COVID‐19 vaccine development. However, LNPs applicable to bacteria have not been reported. Here, the screening of 511 LNPs containing random combinations of different lipid components identified two LNPs, LNP 496 and LNP 470, that efficiently delivered plasmids into Escherichia coli BW25113. Since Gram‐negative bacteria have lipid bilayers, the bacteria are pretreated with LNP‐helper that weakens the bacterial membrane. The cationic lipid DOTAP improved delivery of LNP‐encapsulated plasmid DNA when present at a molar ratio of 10–25 mol% in the LNP. LNP encapsulation of the Cas13a/gRNA expression vector controlled infection by a clinical Escherichia strain in Galleria mellonela larvae and mouse infection models when used in combination with non‐cytotoxic concentrations of polymyxin B, a bacterial membrane disruptor. Together, the results show that LNPs can be useful as a delivery platform for agents that counteract pathogenic bacterial infections.
Thermal‐Assisted Dry Coating Electrode Unlocking Sustainable and High‐Performance Batteries
Authors: Qu Zongtao , Wang Yan , Zhang Chengxiao , Geng Shitao , Xu Qiuchen , Wang Shuo , Zhao Xiaoju , Zhang Xiao , Yuan Bin , Ouyang Zhaofeng , Sun Hao 
Published: November 2024

AbstractCurrent battery production relies on the use of large amounts of N‐methyl‐2‐pyrrolidnone (NMP) solvent during electrode preparation, which raises serious concerns in material cost, energy consumption, and toxicity, thus demanding the innovation of dry electrodes with excellent performance. However, state‐of‐the‐art dry electrodes show inferior energy densities, particularly under high‐areal‐capacity and fast charge/discharge conditions required for practical applications. Here dry production of high‐energy‐density Li‐ and Mn‐rich (LMR) cathodes is shown based on a thermal‐assistant approach. The lithium difluoro(oxalate)borate (LiDFOB) and succinonitrile (SN) serve as two key electrode mediators to facilitate Li+ transport, and the mild heating process for melting SN‐LiDFOB has significantly improved the distribution of various components in the electrode. These synergistic effects enable dry LMR cathodes with a maximum rate capability of 4 C (12 mA cm−2) and an areal capacity of 11.0 mAh cm−2. The resulting Li metal/LMR full cell exhibits the maximum energy and power densities of 609 Wh kg−1 and 2,183 W kg−1, respectively, based on the total mass of the cathode and anode. These results not only break through the key bottleneck in energy density for dry electrodes but, in a broader context, open a new avenue for green and sustainable battery production.
Reversible Anion‐Cation Relay‐Intercalation in a T‐MnO2 Cathode to Boost the Efficiency of Aqueous Dual‐Ion Batteries
Authors: Shin Kyungsoo , Pei Yi , Zhou Xiaolong , Chen Qing , Kidkhunthod Pinit , Zheng Yongping , Guo Xiuli , Tunmee Sarayut , Zhang Qichun , Tang Yongbing 
Published: November 2024

AbstractBenefiting from the merits of intrinsic safety, high power density, environmental friendliness, and high‐output voltage, aqueous dual‐ion batteries (ADIBs) have shown broad potential applications in future grid‐scale energy storage. However, since the ADIBs require the cathodes to undergo the intercalation reactions through different local structures and mechanisms, causing large structural deformation and cathode failure, their reversible cation‐anion intercalation in the cathode remains a major challenge. To address this issue, based on a reasonable selection and theoretical simulation, this work finds that Todorokite manganese dioxide (t‐MnO2) cathode with a metal‐ion stabilized 3 × 3 large‐tunnel structure should be suitable for cation‐anion intercalation of ADIBs. The comprehensive characterizations confirm that the unique tunnel structure of the t‐MnO2 cathode can withstand large structural deformation during the sulfate radical anion– zinc/proton cation (SO42−–Zn2+/H+) intercalation. Due to the intercalation of SO42−, the ADIB delivered a high reversible capacity of 398 mAh g−1 at 0.2 A g−1 with an output voltage of ≈1.41 V, which is much higher than the theoretical capacity (308 mAh g−1) of Zn‐MnO2 based Zinc‐ion batteries. This work provides the design principles for ADIBs cathode materials and demonstrates that t‐MnO2 can be a promising cathode material for high‐performance ADIBs.
Ferroelectric Perovskite/MoS2 Channel Heterojunctions for Wide‐Window Nonvolatile Memory and Neuromorphic Computing
Authors: Xu Haojie , Sun Fapeng , Li Enlong , Guo Wuqian , Hua Lina , Wang Ruixue , Li Wenwu , Chu Junhao , Liu Wei , Luo Junhua , Sun Zhihua 
Published: November 2024

AbstractFerroelectric materials commonly serve as gate insulators in typical field‐effect transistors, where their polarization reversal enables effective modulation of the conductivity state of the channel material, thereby realizing non‐volatile memory. Currently, novel 2D ferroelectrics unlock new prospects in next‐generation electronics and neuromorphic computation. However, the advancement of these materials is impeded by limited selectivity and narrow memory windows. Here, new concepts of 2D ferroelectric perovskite/MoS2 channel heterostructures field‐effect transistors are presented, in which 2D ferroelectric perovskite features customizable band structure, few‐layered ferroelectricity, and submillimeter‐size monolayer wafers. Further studies reveal that these devices exhibit unique charge polarity modulation (from n‐ to p‐type channel) and remarkable nonvolatile memory behavior, especially record‐wide hysteresis windows up to 177 V, which enables efficient imitation of biological synapses and achieves high recognition accuracy for electrocardiogram patterns. This result provides a device paradigm for future nonvolatile memory and artificial synaptic applications.
Cellulose Nanofiber‐Supported Electrochemical Percolation of Capacitive Nanomaterials with 0D, 1D, and 2D Structures
Authors: Hang Chen‐Chen , Zhang Chao , Guan Qing‐Fang , Ye Liqing , Su Yude , Yu Shu‐Hong 
Published: November 2024

AbstractCellulose nanofiber (CNF) represents a promising support material to strengthen the mechanical property of free‐standing supercapacitor electrodes comprised of conducting nanomaterials. Although efforts have been focused on improving the performance of the CNF‐supported electrode, the percolation of capacitive nanomaterials within the insulating CNF matrix, and its correlation with the nanomaterial's dimensionality are still underexplored. In this work, membrane supercapacitor electrodes are fabricated by incorporating CNF with 0D, 1D, and 2D capacitive nanocarbons respectively to study the impact of their dimensionality. It is found that the percolation pathway of the nanocarbons is dependent on their dimensionality. By introducing a new definition termed as electrochemical percolation threshold, the threshold weight percentages to realize effective electrochemical percolation are determined to be 60.0, 14.3, and 66.7% for 0D, 1D, and 2D nanocarbons, respectively. Increasing the weight percentage beyond the threshold typically results in improved electrochemical percolation but reduced mechanical strength, and both trends are dependent on the nanocarbon's dimensionality. The results provide guidance to design efficient and robust CNF‐supported supercapacitor electrodes by controlling the dimensionality and density of the active material. The insights regarding the electrochemical percolation threshold can be applied to other energy‐storage nanomaterials to advance the development of insulator‐supported supercapacitors.
Synthesis of Dibenzoxasilepine Using Ring Expansion Reaction of a Pentacoordinate Silicon Intermediate
Authors: Watanabe Keigo , Sato Mutsuki , Takehara Tsunayoshi , Asano Kaori , Matsuzaki Tsuyoshi , Suzuki Takeyuki , Sako Makoto , Arisawa Mitsuhiro 
Published: November 2024

AbstractDibenzoxasilepine is an important skeleton in both synthetic organic and medicinal chemistry. Here, we have succeeded in obtaining it in higher yield than the conventional method, elucidating for the first time the rearrangement tendency of the two aromatic rings during the ring expansion reaction on the cyclic pentacoordinate silicon intermediate.
Co Modified Pr0.6Sm0.4Mn1O3 Perovskite Enhances the Non‐Radical Pathway for Efficient Removal of Rhodamine B
Authors: Han Dongxu , Song Zhi , Liu Boxia , Liu Bofei , Zhang Xiayan , Liu Jialu , Huang Yeqiong , Xing Chuhan 
Published: November 2024

AbstractBecause of its excellent catalytic activity and stability, perovskite materials are widely used in advanced oxidation processes to remove refractory organic pollutants. In this study, a series of catalysts Pr0.6Sm0.4CoxMn1‐xO3 (x = 0, 0.2, 0.4, 0.5, 0.6,0.8 and 1) with limited range effect are prepared by sol–gel method with the regulation strategy of injecting active metal Co at B site in the crystal lattice of perovskite catalyst Pr0.6Sm0.4MnO3. Under the optimal conditions, the Pr0.6Sm0.4Co0.8Mn0.2O3/PMS/RhB system showed superior catalytic performance, and the removal rate of Rhodamine B (100 mg L−1) is close to 100% within 40 min. In addition, the Pr0.6Sm0.4Co0.8Mn0.2O3 catalyst has a wider pH (2‐10) tolerance range and still has outstanding catalytic properties after multiple cycle tests. The quenching experiment and EPR test confirmed that a variety of active species are produced in the system, and the singlet oxygen as the leading path of a variety of active substances assisted to promote the efficient degradation of Rhodamine B in wastewater. This study provides a new reaction system and regulatory strategy of active structural sites for the design of Fenton‐like catalytic systems based on novel perovskite oxides.
A Mini Review on the Synthesis of Mesoporous Silica and its Application in Antibiotic Removal
Authors: Wang Jingfang , Li Fei , Bao Yueping , Zhan Sihui 
Published: November 2024

AbstractIn recent years, antibiotics have been widely used in multiple fields such as agriculture, forestry, animal husbandry as well as human health due to their high efficiency and low price in treating bacterial infections. However, the misuse of antibiotics has posed a serious threat to both ecological environment and human health, resulting in the antibiotic contamination as a global issue. Therefore, the development of novel materials and technologies to remove antibiotics from water has become a research frontier and hotspot. Meanwhile, mesoporous silica materials have been gradually used in the removal of antibiotics via adsorption and degradation due to their controllable structure, tunable pore size as well as diverse sources. This mini review focuses on the research progress of mesoporous silica in removing antibiotics from aquatic environments. The main types and controllable synthesis procedures of mesoporous silica is introduced first, followed by their application in antibiotics removal via both adsorption and catalytic degradation. Furthermore, it proposes the future directions of this field, providing insights for the use of mesoporous silica materials in water pollution control.
Ultra‐Broad Emission Copper Halide Scintillator‐Based X‐Ray Imager
Authors: Lv Haocheng , Shao Wenyi , Chen Haifeng , Zhu Guoyang , Wang Yao , Zhang Zhenzhong , Liang Hongwei 
Published: November 2024

AbstractLead‐free metal‐halide scintillators are gaining considerable attention as more eco‐friendly and superior alternatives to their lead‐based counterparts. However, novel broad‐emission band scintillators like the state‐of‐the‐art CsI: Tl scintillator, which can generate high signals due to its strong compatibility with the spectral responsivity of regular photodiode arrays, are still less investigated. Herein, a TPA2Cu2I4 (TPACI) copper halide scintillator with a unique ultra‐broad emission (FWHM > 240 nm) is developed, which shows universal compatibility with the peak response range of commercial photodetector. The optical properties characterization and mechanism analysis indicates that this ultra‐broad spectrum can be attributed to the dual self‐trapped exciton (STE) emission consisting of two emission bands. Benefiting from the large Stokes shift and ultra‐broad emission band enabled by the dual STE, the self‐absorption‐free TPACI scintillator exhibits efficient white light emission with a high photoluminescence quantum yields of 94.27%, a high light yield of ≈40124 photons MeV−1. Moreover, a prototype of a TPACI scintillator‐based X‐ray imager is assembled for inspecting the internal structures of biological and electronic devices, which demonstrated a high resolution of 5.5 lp mm−1 at modulation transfer function = 0.2. These findings provide insights into the design of efficient, broad‐emission scintillators for high‐resolution X‐ray imaging.
Tape‐Casting Lead‐Free Dielectrics Permit Superior Capacitive Energy Storage Performance
Authors: Yan Fei , Wang Simin , Qian Jin , Zheng Zihao , Gu Long , Guo Jinming , Zhai Jiwei 
Published: November 2024

AbstractDielectric capacitors have garnered significant attention for their promising attributes in advanced pulse power systems of the future, owing to their rapid charge/discharge capabilities, high power density, and remarkable stability. Whereas environmentally friendly lead‐free ceramics are facing serious challenges of low breakdown strength, poor energy storage density, and/or conversion efficiency, which has been an obstacle to developing desirable dielectric capacitors. In this study, high‐quality ultrathin (<20 µm) lead‐free ceramic dielectrics are successfully produced via the tape‐casting method. The local structural characteristics of these ceramics are verified using piezoresponse force microscopy and aberration‐corrected scanning transmission electron microscopy. By introducing Ta5+ ions into Bi0.39Na0.36Sr0.25TiO3 ceramics, the polar clusters tend to decrease together while the maximum applied electric field tends to increase. This phenomenon can be attributed to the decreased grain size and complex polar structure characterized by extremely small polar clusters, enabling the simultaneous achievement of high applied electric field, large polarization, and minimized polarization hysteresis. Notably, the tape‐casted lead‐free ceramics exhibited exceptional comprehensive energy storage performance with a recoverable energy storage density of ≈10.06 J cm−3 and an efficiency of ≈93% under a high electric field of 915 kV cm−1, surpassing the capabilities of most reported lead‐free ceramics. This work offers a viable solution for developing lead‐free ceramic dielectrics with outstanding energy storage capabilities.
A Self‐Recovery Triboelectric Nanogenerator with High Breakdown Resistance for Water Wave Energy Harvesting
Authors: Wang Jing , Zhao Zhihao , Li Longwei , Gao Yikui , Zhao Xuejiao , Zhang Baofeng , Zhou Linglin , Wang Zhong Lin , Wang Jie 
Published: November 2024

AbstractTriboelectric nanogenerator (TENG) harvesting ocean wave energy is an effective method to alleviate the energy crisis. However, the breakdown phenomenon is ubiquitous for the TENG with a large area of dielectric layer, which not only limits the output and reliability but also highly risks the device failure. Here, a self‐recovery TENG (SR‐TENG) featuring high breakdown resistance is designed, which achieves a high output charge density of 4.24 mC m−2 with the assistance of the charge excitation technique, as well as maintains 87% of the initial output even after six times fierce electric breakdown, minimizing the negative impacts of the breakdown phenomenon. Besides, based on the SR‐TENG, a symmetric anaconda‐shaped self‐charge excited TENG is designed for effective water wave energy harvesting. This work not only sheds light on the self‐recovery phenomenon in TENGs, but also represents a significant step toward the high performance TENG featuring high breakdown resistance and ultimate stability, accelerating the practical applications of TENG for blue energy harvesting.
Covalent Organic Frameworks for Boosting H2O2 Photosynthesis via the Synergy of Multiple Charge Transfer Channels and Polarized Field
Authors: Li Zifan , Dong Zhimin , Zhang Zhibin , Wei Bingqing , Meng Cheng , Zhai Wen , Wang Youqun , Cao Xiaohong , Han Bin , Liu Yunhai 
Published: November 2024

AbstractCovalent organic frameworks (COFs) serve as one of the most promising candidates for hydrogen peroxide (H2O2) photosynthesis, while attaining high‐performance COFs remains a formidable challenge due to the insufficient separation of photogenerated charges. Here, through the rational design of bicarbazole‐based COFs (Cz‐COFs), we showcase the first achievement in piezo‐photocatalytic synthesis of H2O2 using COFs. Noteworthily, the ethenyl group‐modified Cz‐COFs (COF‐DH‐Eth) demonstrates a record‐high yield of H2O2 (9212 μmol g−1 h−1) from air and pure water through piezo‐photocatalysis, which is ca. 2.5 times higher than that of pristine Cz‐COFs without ethenyl groups (COF‐DH‐H) under identical condition and COF‐DH‐Eth without ultrasonic treatment. The H2O2 production rate originates from the synergistic effect between an ultrasonication‐induced polarized electric field and the spatially separated multiple charge transfer channels, which significantly promote the utilization of photogenerated electrons by directional transfer from bicarbazole groups to the ethenyl group‐modified benzene rings. Several Cz‐COFs and bifluorenylidene‐based COFs (COF‐BFTB‐H) with similar twisted monomers exhibit obvious piezoelectric performance for promoting H2O2 generation, signifying that organic ligands with a twistable structure play a crucial role in creating broken symmetry structures, thereby establishing piezoelectric properties in COFs.
Phenol (bio)isosteres in drug design and development
Authors: Dunker Calvin , Schlegel Katja , Junker Anna 
Published: November 2024

AbstractDue to their versatile properties, phenolic compounds are integral to various biologically active molecules, including many pharmaceuticals. However, their application in drug design is often hindered by issues such as poor oral bioavailability, rapid metabolism, and potential toxicity. This review explores the use of phenol bioisosteres–structurally similar compounds that can mimic the biological activity of phenols while potentially offering improved drug‐like properties. We provide an extensive analysis of various phenol bioisosteres, including benzimidazolones, benzoxazolones, indoles, quinolinones, and pyridones, highlighting their impact on the pharmacokinetic and pharmacodynamic profiles of drugs. Case studies illustrate the successful application of these bioisosteres in enhancing metabolic stability, receptor selectivity, and overall therapeutic efficacy. Additionally, the review addresses the challenges associated with phenol bioisosterism, such as maintaining potency and avoiding undesirable side effects. By offering a detailed examination of current strategies and potential future directions, this review serves as a valuable resource for medicinal chemists seeking to optimize phenolic scaffolds in drug development. The insights provided herein aim to facilitate the design of more effective and safer therapeutic agents through strategic bioisosteric modifications.