bluuebunny/crossref_metadata_2025_split huggingface dataset:
GRSF1 is an age-related regulator of senescence
Authors: Kim Su-Jeong , Chun Maria , Wan Junxiang , Lee Changhan , Yen Kelvin , Cohen Pinchas 
Published: April 2019

AbstractSenescent cells that accumulate in multiple tissues with age are thought to increase pathological phenotypes. The removal of senescent cells can improve lifespan and/or healthspan in mouse models. Global hypomethylation and local hypermethylation in DNA are hallmarks of aging but it is unclear if such age-dependent methylation changes affect specific genes that regulate cellular senescence. Because mitochondria play important roles in aging and senescence, we tested if age-associated methylation changes in nuclear-encoded mitochondrial proteins were involved in regulating cellular senescence. Here, we examined the role of hypermethylation of the G-rich sequence factor 1 (GRSF1) promoter region, a mitochondrial RNA binding protein, in replication- and doxorubicin-induced cellular senescence. GRSF1 expression was lower in senescent fibroblasts, and GRSF1 knockdown induced senescence in human primary fibroblasts. These results suggest that the age-dependent hypermethylation of GRSF1 reduces its expression, which can potentially contribute to cellular senescence during aging.
Tailoring exceptional points with one-dimensional graphene-embedded photonic crystals
Authors: Chen Shanshan , Zhang Weixuan , Yang Bing , Wu Tong , Zhang Xiangdong 
Published: April 2019

AbstractWe theoretically demonstrate that tunable exceptional points (EPs) can be realized by using graphene-embedded one-dimensional (1D) photonic crystals with optical pumping in the terahertz (THz) frequency range. By tuning the Fermi level of graphene sheet, the energy band are altered significantly and the EP appears. In particular, multiple EPs at different frequencies can be selectively produced via subtly adjusting the band structure. Furthermore, topological features of these EPs, such as crossing and anti-crossing of the real and imaginary parts of the eigenvalues, have been analyzed in detail. We expect that tunable EPs can provide an instructive method to design active optical devices based on photoexcited graphene sheets in the THz frequency range.
Interlayer charge transport controlled by exciton–trion coherent coupling
Authors: Kallatt Sangeeth , Das Sarthak , Chatterjee Suman , Majumdar Kausik 
Published: April 2019

AbstractThe possibility of electrical manipulation and detection of a charged exciton (trion) before its radiative recombination makes it promising for excitonic devices. Using a few-layer graphene/monolayer WS2/monolayer graphene vertical heterojunction, we report interlayer charge transport from top few-layer graphene to bottom monolayer graphene, mediated by a coherently formed trion state. This is achieved by using a resonant excitation and varying the sample temperature; the resulting change in the WS2 bandgap allows us to scan the excitation around the exciton–trion spectral overlap with high spectral resolution. By correlating the vertical photocurrent and in situ photoluminescence features at the heterojunction as a function of the spectral position of the excitation, we show that (1) trions are anomalously stable at the junction even up to 463 K due to enhanced doping, and (2) the photocurrent results from the ultrafast formation of a trion through exciton–trion coherent coupling, followed by its fast interlayer transport. The demonstration of coherent formation, high stabilization, vertical transportation, and electrical detection of trions marks a step toward room-temperature trionics.
First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro
Authors: Wernitznig Debora , Kiakos Konstantinos , Del Favero Giorgia , Harrer Nathalie , Machat Herwig , Osswald Annika , Jakupec Michael A , Wernitznig Andreas , Sommergruber Wolfgang , Keppler Bernhard K 
Published: April 2019

Abstract
The ruthenium complex sodium trans-[tetrachloridobis(1H-indazole)ruthenate(iii)] (KP1339/IT-139) showed preclinical activity in a variety of in vivo tumor models including a highly predictive colon cancer model. The compound has entered clinical trials, where patients experienced disease stabilization accompanied by mild side effects. KP1339, a GRP78 inhibitor, disrupts endoplasmic reticulum (ER) homeostasis leading to cell death. The PERK/eIF2α-branch of the ER plays an essential role in the cascade of events triggering immunogenic cell death (ICD). ICD makes dying cancer cells ‘visible’ to the immune system, initiating a prolonged immune response against the tumor. As some metal-based chemotherapeutics such as oxaliplatin are able to induce ICD, we investigate whether KP1339 could also trigger induction of the ICD signature. For this, we employ a three-dimensional colon cancer spheroid model and show for the first time that the treatment with KP1339, a ruthenium-based complex, triggers an ICD signature hallmarked by phosphorylation of PERK and eIF2α, exposure of calreticulin on the cell membrane, release of high mobility group box 1 and secretion of ATP.
LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma
Authors: Chen Si , Li Weiguo , Guo Ai 
Published: April 2019

Abstract
lncRNA LOXL1 antisense RNA 1 (lncRNA LOXL1-AS1) was recently found to function as oncogenic lncRNA in glioblastoma, prostate cancer, and medulloblastoma. The role of LOXL1-AS1 in osteosarcoma was still unknown. In our study, we found LOXL1-AS1 expression levels were higher in osteosarcoma tissues and cell lines than normal bone tissues and normal osteoblast cell line, respectively. Moreover, high-expression of LOXL1-AS1 was correlated with Enneking stage, tumor size, distant metastasis, histological grade, and overall survival time in osteosarcoma patients. Furthermore, LOXL1-AS1 overexpression acted as an independent poor predictor for overall survival in osteosarcoma patients. The loss-of-function studies showed knockdown of LOXL1-AS1 dramatically inhibited osteosarcoma cell proliferation, migration, and invasion through suppressing PI3K-AKT pathway. In conclusion, LOXL1-AS1 predicts clinical progression and poor prognosis in osteosarcoma patients and functions as oncogenic lncRNA to regulate cell proliferation, cell cycle, migration, and invasion.
Genome-level responses to the environment: plant desiccation tolerance
Authors: Silva Artur Mariana A. , Costa Maria-Cecília D. , Farrant Jill M. , Hilhorst Henk W.M. 
Published: April 2019

Abstract
Plants being sessile organisms are well equipped genomically to respond to environmental stressors peculiar to their habitat. Evolution of plants onto land was enabled by the ability to tolerate extreme water loss (desiccation), a feature that has been retained within genomes but not universally expressed in most land plants today. In the majority of higher plants, desiccation tolerance (DT) is expressed only in reproductive tissues (seeds and pollen), but some 135 angiosperms display vegetative DT. Here, we review genome-level responses associated with DT, pointing out common and yet sometimes discrepant features, the latter relating to evolutionary adaptations to particular niches. Understanding DT can lead to the ultimate production of crops with greater tolerance of drought than is currently realized.
Ka‐band wideband VCO with LC filtering technique in 65‐nm CMOS
Authors: Ding Tianao , Fan Xiangning , Zhao Dixian 
Published: April 2019

This Letter reports a 25.80–30.84 GHz wideband millimetre‐wave VCO in 65‐nm CMOS technology. A 4‐bit binary‐weighted capacitor bank is used to extend the tuning range. The PMOS current source, as well as the LC noise filtering network, are used to improve the phase‐noise performance. Occupying a core area of 0.056 mm2, the implemented VCO core consumes 4.1 mW at a 1 V supply. At 26 GHz, it achieves a phase noise of −102.8 dBc/Hz at 1 MHz offset.
High‐power DC–DC converter utilising Scott transformer connection
Authors: Milovanović Stefan , Dujić Dražen 
Published: April 2019

To obtain a resilient and flexible DC grid, reliable means for interfacing its parts operating under different voltage levels must be ensured. This paper proposes bidirectional, isolated, DC–DC converter designed to connect either high/medium voltage bipolar DC grid or two separate high/medium voltage DC grids with another DC grid of similar or different voltage level. In order to achieve galvanic separation among converter stages, while providing redundancy in case of the converter parts malfunction or a DC feeder loss, Scott transformer connection is employed. So far, Scott transformer connection has mostly been used in the railway applications, implying low‐frequency operation, in order to obtain two single‐phase voltages from a symmetrical three‐phase grid. However, its use in the field of the DC–DC conversion has never been analysed in the literature. Further, this paper emphasises operating frequency shift towards the medium frequency range, following the trend of the solid‐state transformers which have drawn the attention of both academia and industry worldwide. To control the converter power flow, phase shift control principles are adopted. Consequently, control simplicity is retained, while achieving system complexity reduction. At last, in order to evaluate proposed converter performance, simulation results of a 40 kV/1.5 kV, 10 MW converter are presented, illustrating excellent operating performances.
Bound states of purely relativistic nature
Authors: Karmanov V.A. , Carbonell J. , Sazdjian H. 
Published: April 2019

Two particles interacting by photon exchange, form the bound states predicted by the non-relativistic Schrödinger equation with the Coulomb potential (Balmer series). More than 60 years ago, in the solutions of relativistic Bethe-Salpeter equation, in addition to the Balmer series, were found another series of energy levels. These new series, appearing when the fine structure constant α is large enough (α > π/4), are not predicted by the Schrödinger equation. However, this new (non-Balmer) states can hardly exist in nature, since in order to create a strong e.m. field with α > π/4 a point-like charge Z > 107 is needed. The nuclei having this charge, though exist starting with bohrium, are far from to be point-like.
In the present paper, we analyze the more realistic case of a strong interaction created by exchange of a massive particle. It turns out that in the framework of the Bethe-Salpeter equation this interaction still generates a series of new relativistic states, which are similar to those of the massless exchange case, and which are absent in the Schrödinger equation. The properties of these solutions are studied. Their existence in nature seems possible.
Operative Management of Anastomotic Leaks after Colorectal Surgery
Authors: Saur Nicole , Paulson E. 
Published: April 2019

AbstractAnastomotic leak is associated with increased morbidity and mortality after colorectal surgery. Although surgical techniques have improved over time, anastomotic leak is still a reality in colorectal surgery with rates ranging from as low as 1% for low-risk anastomoses, such as enteroenteric or ileocolic, to 19% for high-risk coloanal anastomoses. There are many varied risk factors for anastomotic leak. However, many of the risk factors have not been definitively proven in high-quality studies. Presumably, risk factors are cumulative and every effort should be made to optimize modifiable risk factors in the perioperative period. Treatment of anastomotic leak should start with the determination of patient stability followed by resuscitation and diagnostic imaging or operative exploration. Operative findings will dictate surgical approach with the goal of controlling sepsis and stabilizing the patient. If nonoperative treatment is undertaken, close patient monitoring is necessary to ensure control of sepsis and that intervention is undertaken if the clinical picture changes. Early intervention at each stage is key to decreasing the morbidity of anastomotic leak.
Overlooked Long-Term Complications of Colorectal Surgery
Authors: Giglia Matthew , Stein Sharon 
Published: April 2019

AbstractWhile colorectal surgery has been documented to have some of the highest complication rates in the surgical field, some of the more common, functional complications are often overlooked in the literature and in discussion with patients. Urinary, sexual, and defecatory dysfunction are common after colorectal surgery, especially after pelvic dissections, and may severely impact the postoperative quality of life for patients. These complications include urinary retention, erectile dysfunction, retrograde ejaculation, dyspareunia, infertility, and low anterior resection syndrome. The majority is rooted in autonomic nerve damage, both sympathetic and parasympathetic, that occurs during mobilization and resection of the sigmoid colon and rectum. While not all of these postoperative complications are preventable, treatment strategies have been developed to ameliorate the impact on quality of life. Given the high incidence and direct effect on patients, clinicians should be familiar with the etiology, prevention, and treatment strategies of these complications to provide the highest quality of care.
Autoimmune Progesterone Dermatitis: A Case Report
Authors: Özdemir Özhan , Yahşi Gözde Girgin , Atalay Cemal Reşat 
Published: April 2019

Introduction Autoimmune progesterone dermatitis (APD) is a rare autoimmune dermatosis characterized by recurrent cutaneous and mucosal lesions during the luteal phase of the menstrual cycle that disappear some days after the menses.
Case Report A 34-year-old primipara woman with no significant past medical history and no prior exogenous hormone use, who presented with cyclic skin eruptions starting 1 year after the delivery. The lesions occurred ∼ 6 days before the menses and disappeared in between 1 and 2 days after the menstruation ceased. The patient was diagnosed after a positive response to an intradermal test with progesterone and was successfully treated with combined oral contraceptives. The skin eruptions have not returned since the initiation of this therapy.
Conclusion Dermatologists, gynecologists, and obstetricians should be aware of this rare entity. Furthermore, if this condition is suspected, a thorough history taking on the menstrual cycle and results of the intradermal progesterone test are mandatory.
Accuracy in Determining Canal Flare Index Using Different Radiographical Positions for Imaging Canine Femurs
Authors: de Andrade Caroline , Minto Bruno , Dreibi Rafael , Diogo Lúcia , Kawamoto Fernando , Franco Guilherme , Uscategui Ricardo , Dias Luís 
Published: April 2019

Objective The aim of this study was to compare in vitro accuracy of femoral measurements obtained from different radiographical positions with actual femoral anatomical dimensions in dogs.
Materials and Methods Craniocaudal projections of the femur in ventrodorsal position, standard craniocaudal radiographical (SR) and craniocaudal radiography with horizontal radiographical beam (HR), in addition to anatomical macroscopic measurements (A), were obtained from 45 femurs from 23 canine cadavers, for calculation of the canal flare index (CFI). The differences between the radiographical positions and 95% limits of agreement (LOA) between the CFI-SR, CFI-HR and CFI-A were evaluated by the Bland–Altman method.
Results The standard craniocaudal radiograph provided an approximate dimension of the proximal femoral morphology (mean difference: 0.121 ± 0.391) with a different CFI value (p = 0.0341) from CFI-A. The craniocaudal radiograph taken using a horizontal beam provided greater accuracy (mean difference: 0.087 ± 0.42) in our study.
Clinical Significance The craniocaudal projection using a horizontal radiographical beam was more accurate than the standard craniocaudal projection for measurement of the true anatomical dimensions of the canine femur, minimizing the influence of the technique on the CFI values.
Nonsurgical Chin and Jawline Augmentation Using Calcium Hydroxylapatite and Hyaluronic Acid Fillers
Authors: Moradi Amir , Shirazi Azadeh , David Roy 
Published: April 2019

AbstractThe shape of the jawline from the mandibular angle to its most forward point at the chin has a profound effect on an individual's appearance and is an area of concern for many seeking esthetic procedures. Dermal filler injections alone or in combination with other modalities, such as skin tightening energy devices, allow enhancement of the jawline while avoiding the need for surgical procedures. The authors introduce new anatomical zones and nomenclature to enhance safety and outcome when enhancing the jawline. Cadaver dissections were performed to better understand landmarks and potential risks and a topographic guide proposed to assist clinicians to create an esthetically pleasing jawline. Techniques for jawline rejuvenation with calcium hydroxylapatite (CaHA) and high G prime hyaluronic acid (HA) fillers are described. When considered as an esthetic unit, the jawline can be broken down into masseteric, buccal, and mental zones, each with their own injection protocols and safety considerations. Dermal fillers suitable for jawline rejuvenation include either CaHA with or without integral lidocaine, a high G prime HA filler, or a hybrid mixture of CaHA and HA, depending on the desired esthetic outcome and the individual's needs. Small volumes of product per injection point achieve the most natural esthetic outcome and minimize serious adverse events. With these techniques, the angle of the mandible is better defined, the pre- and postjowl hollows are filled, and as a result the jawline appears visibly straighter. CaHA and high G prime HA fillers are effective nonsurgical treatments for redefining the mandibular angle and straightening the contour of the jaw. For optimal results, the jawline should be considered as an esthetic unit and careful consideration paid to anatomical landmarks that influence efficacy and safety.
Clinical and Anatomical Aspects of Anterior Dislocation of the Pisiform Bone
Authors: Rueff-Barroso Carlos Romualdo , Delpupo Fernanda Vieira Botelho , Fazan Valéria Paula Sassoli , Nascimento Sérgio Ricardo Rios , Nunes Lerud Frosi , Montenegro Rudi Natalli , Kriger Jorge Luiz , Barroso Bernardo Garcia 
Published: April 2019

Introduction The pisiform bone is the fourth bone of the proximal row of the carpal bones, and it is located in the tendon of the flexor carpi ulnaris muscle, being considered a sesamoid bone. Traumatic dislocation of the pisiform bone is a rare condition, which usually results from a trauma in dorsal flexion of the wrist. Its treatment can be conservative or surgical, ending or not with the removal of the pisiform bone.
Objective To report a case of a child who fell from his own height and presented wrist pain, diagnosed with dislocation of the pisiform bone. We emphasize the importance of anatomy knowledge in the evaluation of wrist trauma.
Case Report The anamnesis confirmed that the fall occurred with the wrist in hyperextension. The physical examination showed a slight limitation of movement due to pain. Radiographic exams and a computed tomography (CT) scan of the wrist were performed, in which an anterior deviation/luxation of the pisiform bone was evidenced. A conservative treatment with plaster immobilization for analgesia was performed for 1 week. As there were no symptoms and no signs of trauma consistent with the images, such as edema and local ecchymosis, in addition to the early complete disappearance of pain, the responsible team proposed the hypothesis of asymptomatic chronic dislocation of the pisiform bone.
Conclusion Imaging exams in orthopedic traumatology are fundamental for an accurate diagnosis. Nevertheless, they must be associated with knowledge of the anatomy to correlate the image findings with the anamnesis, leading to a better understanding of silent, asymptomatic, and preexisting conditions in the clinical practice.
Optimizing the Chin and Jawline Appearance: Does Surgery or Injection Make Sense?
Authors: Chin Oliver , Sykes Jonathan 
Published: April 2019

AbstractThe chin is a crucial landmark and mandates careful consideration for facial appearance. Optimal chin appearance requires evaluation and treatment in three dimensions: anteroposterior, transverse, and vertical planes. The optimization of chin deficiencies requires understanding of bony anatomy as well as the relationship of the adjacent facial structures including the lip, teeth, and nose. The practitioner should be familiar with techniques in injection, placement of alloplastic implants, as well bony genioplasty.
Application of ICF-CY Core Sets in Children with Spastic Cerebral Palsy
Authors: Mukhtiar Khairunnisa , Ibrahim Shahnaz , Ahmed Mukhtiar 
Published: April 2019

AbstractIn this study, we applied brief age-specific core sets of international classification of functioning, disability, and health in children and youth (ICF-CY) in children with spastic cerebral palsy (CP). It was a descriptive cross-sectional study. One hundred children with spastic CP, age range 1 to 6 years, were included in the study. Thirty-one age-specific brief ICF core sets were applied to children with spastic CP to assess their functional status. Common areas of impairments in children with spastic CP were the body functions and activities and participation. Environmental factors were also a major limitation in the care of CP. The application of ICF core sets provides a novel and standardized approach in describing the functional profile of children with CP. Through application of these core sets, we can standardize the functional assessments of CP worldwide.
Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity
Authors: Allen-Redpath Keith , Aldrovandi Maceler , Lauder Sarah N. , Gketsopoulou Anastasia , Tyrrell Victoria J. , Slatter David A. , Andrews Robert , Watkins W. John , Atkinson Georgia , McNeill Eileen , Gilfedder Anna , Protty Majd , Burston James , Johnson Sam R. C. , Rodrigues Patricia R. S. , Jones Dylan O. , Lee Regent , Handa Ashok , Channon Keith , Obaji Samya , Alvarez-Jarreta Jorge , Krönke Gerhard , Ackermann Jochen , Jenkins P. Vince , Collins Peter W. , O’Donnell Valerie B. 
Published: April 2019

Significance
Abdominal aortic aneurysm (AAA) is a disease of the abdominal aorta where inflammation causes damage and can ultimately lead to rupture. When this happens, uncontrolled internal bleeding can lead to death within minutes. Many aneurysms are not detected until they rupture, and for those that are, treatments to stop them progressing are limited. Here we used biophysics and genetically modified mice to show that a new family of lipids (fats) made by circulating blood cells promote AAA formation in the vessel wall because they directly regulate blood clotting. An approach that prevents AAA development was identified, based on intravenous administration of lipids. The studies provide insights into how AAA develops and may lead to novel therapies for this disease.