bluuebunny/crossref_metadata_2025_split huggingface dataset:
The perception of e-servicescape and its influence on perceived e-shopping value and customer loyalty
Authors: Tankovic Ana Cuic , Benazic Dragan 
Published: August 2018

Purpose
The popularity of online shopping has grown in the recent years, enhancing the interest in identifying the factors that influence shoppers’ loyalty. The purpose of this paper is to investigate, through aesthetic appeal, layout and functionality, and financial security, the impact of customers’ perceptions of the e-servicescape in online shopping on perceived e-shopping value and customer loyalty defined as a two-component construct (attitudinal loyalty and behavioural loyalty), following the sequence of the S–O–R framework.

Design/methodology/approach
Data were gathered using an Internet survey in which 221 active online shoppers participated who had at least one online purchase in the past six months. The research model was analysed using the partial least squares approach to analyse structural equations (SEM).

Findings
Based upon empirical evidence of a web-based survey of online shoppers, this study shows that consumers’ interpretation of e-servicescape exerts a positive influence over perceived e-shopping value and loyalty. Specifically, the study finds that layout and functionality and financial security, as the salient attributes of the e-servicescape dimension, set the point of perceived e-shopping value which affects attitudinal loyalty.

Practical implications
The authors expose several practical implications how marketing management could use the dimensions of e-servicescape perceived e-shopping value. Managers are advised to incorporate the dimensions of the e-servicescape to build perceived e-shopping value and loyalty. Online shops need to invest in particular in layout and functionality and financial security, dimensions that had a stronger effect on perceived e-shopping value in order to achieve costumers’ loyalty in a fashion product context.

Originality/value
The transition from physical service locations to virtual service processes has increased the research interest of e-servicescape. This study analyses it through its aesthetic appeal, layout and functionality, and financial security connecting them with the constructs of perceived e-shopping value and customer loyalty in the application for fashion products. This work emphasises the connection between servicescape attributes in creating perceived value which affects attitudinal and behavioural loyalty. In this way, the e-servicescape is seen as stimuli, the perceived e-shopping value represents the organism and the loyalty the response of the sequence of the S–O–R framework. This research provides insight into the new effects of each dimension of e-servicescape on perceived e-shopping value and the two dimensions of loyalty, thus improving the existing knowledge in the field of servicescape and online shopping customer behaviour.
Dual Use and Hospital Admissions among Veterans Enrolled in the VA's Homeless Patient Aligned Care Team
Authors: Trivedi Amal N. , Jiang Lan , Johnson Erin E. , Lima Julie C. , Flores Michael , O'Toole Thomas P. 
Published: August 2018

ObjectiveTo examine the association between reliance on VA outpatient care and hospital admissions among Medicare‐eligible Veterans enrolled in the Homeless Patient Aligned Care Team (H‐PACT).Data Sources/Study SettingRegistry of H‐PACT enrollees linked to VA and Medicare utilization data for 2013.Study DesignAfter assigning Veterans to two groups according to whether they received >90 percent of outpatient care in VA (higher reliance) or <90 percent of outpatient care in VA (lower reliance), generalized linear models with inverse probability of treatment weights were used to estimate the association of reliance with Medicare and VA‐financed hospital admissions.Principal FindingsCompared with higher reliance Veterans, lower reliance Veterans had an equivalent number of annual VA hospitalizations (0.63 vs. 0.50; p = .14) but substantially greater Medicare hospitalizations (0.85 vs. 0.08; p < .001). Among Veterans in the highest tertile of outpatient visits, we observed statistically similar rates of VA hospital use but over 10‐fold greater rates of Medicare‐financed hospitalizations (1.31 for lower reliance vs. 0.15 for high reliance; p < .001).ConclusionsAmong Veterans receiving integrated care in VA's H‐PACT, dual use of Medicare and VA outpatient care is strongly associated with acute hospitalizations financed by Medicare. Linking VA and non‐VA data may identify a subset of homeless Veterans with fragmented outpatient care who are at increased risk of poor outcomes.
Development of an Adverse Event Surveillance Model for Outpatient Surgery in the Veterans Health Administration
Authors: Mull Hillary J. , Itani Kamal M. F. , Pizer Steven D. , Charns Martin P. , Rivard Peter E. , McIntosh Nathalie , Hawn Mary T. , Rosen Amy K. 
Published: August 2018

ObjectiveDevelop and validate a surveillance model to identify outpatient surgical adverse events (AEs) based on previously developed electronic triggers.Data SourcesVeterans Health Administration's Corporate Data Warehouse.Study DesignSix surgical AE triggers, including postoperative emergency room visits and hospitalizations, were applied to FY2012–2014 outpatient surgeries (n = 744,355). We randomly sampled trigger‐flagged and unflagged cases for nurse chart review to document AEs and measured positive predictive value (PPV) for triggers. Next, we used chart review data to iteratively estimate multilevel logistic regression models to predict the probability of an AE, starting with the six triggers and adding in patient, procedure, and facility characteristics to improve model fit. We validated the final model by applying the coefficients to FY2015 outpatient surgery data (n = 256,690) and reviewing charts for cases at high and moderate probability of an AE.Principal FindingsOf 1,730 FY2012–2014 reviewed surgeries, 350 had an AE (20 percent). The final surveillance model c‐statistic was 0.81. In FY2015 surgeries with >0.8 predicted probability of an AE (n = 405, 0.15 percent), PPV was 85 percent; in surgeries with a 0.4–0.5 predicted probability of an AE, PPV was 38 percent.ConclusionsThe surveillance model performed well, accurately identifying outpatient surgeries with a high probability of an AE.
Streamflow, Sediment Transport, and Geomorphic Change during the 2011 Flood on the Missouri River Near Bismarck–Mandan, ND
Authors: Nustad Rochelle A. , Benthem Adam J. , Skalak Katherine J. , McDonald Richard R. , Schenk Edward R. , Galloway Joel M. 
Published: August 2018

AbstractGeomorphic change from extreme events in large managed rivers has implications for river management. A steady‐state, quasi‐three‐dimensional hydrodynamic model was applied to a 29‐km reach of the Missouri River using 2011 flood data. Model results for an extreme flow (500‐year recurrence interval [RI]) and an elevated managed flow (75‐year RI) were used to assess sediment mobility through examination of the spatial distribution of boundary or bed shear stress (τb) and longitudinal patterns of average τb, velocity, and kurtosis of τb. Kurtosis of τb was used as an indicator of planform channel complexity and can be applied to other river systems. From differences in longitudinal patterns of sediment mobility for the two flows we can infer: (1) under extreme flow, the channel behaves as a single‐thread channel controlled primarily by flow, which enhances the meander pattern; (2) under elevated managed flows, the channel behaves as multithread channel controlled by the interaction of flow with bed and channel topography, resulting in a more complex channel; and (3) for both flows, the model reach lacks a consistent pattern of deposition or erosion, which indicates migration of areas of erosion and deposition within the reach. Despite caveats and limitations, the analysis provides useful information about geomorphic change under extreme flow and potential implications for river management. Although a 500‐year RI is rare, extreme hydrologic events such as this are predicted to increase in frequency.
Effects of patient satisfaction and confidence on the success of treatment of combined rheumatic disease and interstitial lung disease in a multidisciplinary outpatient clinic
Authors: Jeong Shin Ok , Uh Soo‐Taek , Park Suyeon , Kim Hyun‐Sook 
Published: August 2018

AbstractObjectivesMultidisciplinary discussions (MDDs) have emphasized improve medical services and outcomes. We used a multidisciplinary approach to explore whether patient emotional satisfaction and confidence affected treatment outcomes in rheumatic disease (RD)‐related interstitial lung disease (ILD).MethodsFrom December 2015 to April 2017, we evaluated 23 patients with RD and ILD and 21 with idiopathic pulmonary fibrosis (IPF). Patients with RD and ILD were managed with MDDs. Patients with IPF received standardized medical care by the same pulmonologist. All patients completed brief multiple‐choice questionnaires exploring their perceptions of their illnesses and their attitudes toward medical treatment, and completed the Patient Health Questionnaire‐2.ResultsThe MDD patients could more easily identify disease symptoms regardless of age stratification (under 65 age: P = 0.020, 65 years or older: P = 0.003). Among the 65 years or older group, it shows higher levels of illness perception in terms of disease timeline in the MDD group (P = 0.035). Also, the MDD group reported higher levels of satisfaction in terms of the explanations they received and their involvement in discussion, and greater satisfaction with medical staff. However, the groups did not differ significantly between treatment outcomes such as changes in forced vital capacity, the diffusion capacity of carbon monoxide, or changes in high‐resolution computed tomography.ConclusionsMDDs afforded satisfactory management compared with standardized medical care. The MDD group felt better attention fromand satisfaction with medical staff, and had greater identification in their treatment. Further research engaging in MDDs with a comparable control group is required.
Long‐term follow‐up of 76 Iranian patients with idiopathic inflammatory myopathies
Authors: Hajialilo Mehrzad , Ghorbanihaghjo Amir , Khabbazi Alireza , Kolahi Sousan , Jafari Nakhjavani Mohammad Reza , Ebrahimi Ali Asghar , Zareh Hamid , Malek Mahdavi Aida 
Published: August 2018

AbstractAimThis study aimed to follow up patients with polymyositis (PM) and/or dermatomyositis (DM) to determine survival rate, pattern of disease, response to treatment, malignancy incidence and poor prognostic factors (PPFs).MethodA total of 76 patients with PM (n = 47) and/or DM (n = 29) based on Bohan and Peter diagnostic criteria referred to the Imam‐Reza Hospital were followed up from 2004 to 2016. The follow‐up period was considered from diagnosis to patient′s death or last visit. All patients underwent physical examinations and data including age, sex, disease duration, disease subtype, pattern of disease, PPFs and malignancy incidence were collected.ResultsMean age at diagnosis was 45.49 ± 10.88 years and women were predominant (84.2%). Course of disease in the majority of patients (52.6%) was polyphasic, followed by monophasic (31.6%) and chronic‐progressive (5.3%). The 1‐, 5‐ and 10‐year survival rates were 96%, 93% and 92%, respectively. Delay in treatment and dysphagia were common PPFs in the present study. The majority of patients responded to treatment (88.2%) and there were significant differences in cancer and dysphagia between responders and non‐responders to treatment (P < 0.05). The most common cause of death was cancer in four of eight deaths. There was significant difference in survival rates between patients with and without pulmonary involvement (P = 0.001). Moreover, the survival rates were significantly lower in patients with malignancy (P = 0.001).ConclusionPresence of dysphagia and cancer were associated with poor response to treatment. Pulmonary involvement and cancer incidence significantly affect survival rate. Furthermore, since cancer is the most common cause of death, so this study emphasizes the importance of careful cancer screening in these patients.
Emerging role of metabolomics in rheumatology
Authors: Gupta Latika , Ahmed Sakir , Jain Avinash , Misra Ramnath 
Published: August 2018

AbstractThe pursuit for understanding disease pathogenesis, in this age of rapid laboratory diagnostics and fast‐paced research, has led scientists worldwide to take recourse in hypothesis‐free approaches for molecular diagnosis. Metabolomics is one such powerful tool that explores comprehensibly the metabolic alternations in human diseases. It involves study of small molecules of less than 1 kD in size by either LSMS or nuclear magnetic resonance. Unlike genomics, which tells us what may have happened, metabolomics reflects what did happen. The NMR technique has an advantage of analyzing metabolites without sample preparation, thereby diminishing artifacts, is less cumbersome and with the latest database on Metabolome; about 30 000 metabolites can be identified. The study of metabolomics for several rheumatic diseases, including rheumatoid arthritis, lupus, osteoarthritis and vasculitis, has revealed distinctive metabolic signatures. Thus, metabolomics is a technique that promises precision medicine with better biomarkers, robust predictors of drug response and of disease outcome, discovery of newer metabolites and pathways in disease pathogenesis, and finally, targeted drug development. This review intends to decipher its relevance in common rheumatic diseases.
Apigenin and apigeninidin isolates from theSorghum bicolorleaf targets inflammation via cyclo‐oxygenase‐2 and prostaglandin‐E2blockade
Authors: Makanjuola Samira B. L. , Ogundaini Abiodun O. , Ajonuma Louis C. , Dosunmu Adedoyin 
Published: August 2018

AbstractAimThis study evaluated the anti‐inflammatory properties of a species ofSorghum bicolorleaf (SBL) grown in West Africa.MethodCyclo‐oxygenase (COX)‐2:COX‐1 selectivity assay was carried out by plating isolated peripheral blood mononuclear cells in culture medium with specific SBL fractions: crude extract (J), ethyl‐acetate (JE) and aqueous (JA); secondary compounds from JE (JE5, JE6, JE7 and JE8); purified (P9) and semi‐purified (P8) compounds from JE5 at 5‐200 μg/mL for 1 hour. Test compounds and controls ibuprofen (50 μmol/L) and CAY10404 (1 μmol/L; 10 μmol/L) were added to two sets of plates, one without lipopolyshaccharide (LPS) and the other with LPS (1 μg/mL) for 24 hour. COX‐2IC50:COX‐1IC50ratio represented 50% inhibition of the activity of COX‐2 to that of COX‐1 using ibuprofen as control. In separate experiments the supernatant of P8 and P9‐treated fractions of SBL and controls were plated with RAW 264.7 macrophage cells to measure prostaglandin (PG)‐E2production and cell proliferation activity.ResultsJA fraction of SBL had the highest ratio of COX‐2IC50:COX‐1IC5041.214whereas JE had the lowest ratio COX‐2IC50:COX‐1IC501.161. Interestingly, JE5 derived from JE showed a ratio of COX‐2IC50:COX‐1IC500.495while P8 derived from JE5 showed a dose‐dependent reduction in COX‐2IC50:COX‐1IC50ratio and in PG‐E2production, which was more effective compared to ibuprofen. A dose‐dependent reduction in RAW 264.7 macrophage cell proliferation was also observed in P8‐treated cells. The phenolic compounds identified in P8 include apigenin and apigeninidin adducts which may explain the exceptional anti‐inflammatory activity and efficacy in COX‐2 targeting.
Pretreatment hematological markers predict clinical outcome in cancer patients receiving immune checkpoint inhibitors: A meta‐analysis
Authors: Tan Qiaoyun , Liu Shuxia , Liang Caixia , Han Xiaohong , Shi Yuankai 
Published: August 2018

BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized the clinical treatment of multiple cancers. Recent studies revealed the potential prognostic value of the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients receiving ICIs; however, the results were inconsistent. We conducted a meta‐analysis to identify the prognostic significance of baseline NLR and PLR in cancer patients treated with ICIs.MethodsWe conducted a thorough literature search of PubMed, Embase, and Cochrane databases for studies dealing with the prognostic impact of pretreatment NLR and/or PLR levels in cancer patients treated with ICIs. The clinical outcomes were progression‐free survival (PFS) and overall survival (OS). Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated, and sensitivity and subgroup analyses were performed to investigate heterogeneity.ResultsSeventeen articles involving 2092 patients were included in the final analysis. The pooled HRs of PFS and OS for NLR were 1.81(95% CI 1.36–2.41) and 2.26 (95% CI 1.68–3.03), respectively, suggesting that patients with higher baseline NLRs had significantly poorer PFS and OS. Similar results were detected in sensitivity and subgroup analyses. However, no significant relevance was found between PLR and clinical endpoints in patients treated with ICIs (HR = 1.14, 95% CI 0.88–1.48 for PFS; HR = 1.35, 95% CI 0.86–2.12 for OS).ConclusionThese results indicate that high pretreatment NLR but not PLR level, as a routinely obtained hematological parameter, is a potential prognostic predictor for poor PFS and OS in cancer patients receiving ICIs.
Population‐level patterns and mental health and substance use correlates of alcohol, marijuana, and tobacco use and co‐use in US young adults and adults: Results from the population assessment for tobacco and health
Authors: Cohn Amy M. , Johnson Amanda L. , Rose Shyanika W. , Pearson Jennifer L. , Villanti Andrea C. , Stanton Cassandra 
Published: August 2018

Background and ObjectivesThis study identified the most common patterns of current alcohol and marijuana use with the spectrum of tobacco products (cigarettes, hookah, e‐cigarettes, cigars/little cigars, and other products), among US young adults and older adults and examined associations of mental health and substance use problems with each pattern.MethodsWave 1 adult dataset (2013–2014) of the Population Assessment of Tobacco and Health (PATH) Study. Weighted analyses estimated the prevalence of the top 10 patterns of current alcohol, marijuana, and tobacco use and co‐use separately by young adults aged 18–24 (n = 9,112) and adults 25+ years (n = 23,208). Multivariable models examined associations of substance use and mental health problems to patterns of use, adjusting for demographics.ResultsAcross both age groups, alcohol‐only use was the most popular use pattern (20.7% for young adults and 32.2% older adults) however poly‐substance use patterns were more frequent than single use patterns. Cigarettes were the only tobacco product used exclusively; all other tobacco products were used with together, or with alcohol or marijuana. Only one young adult pattern emerged containing e‐cigarettes, and this pattern included co‐use with alcohol and cigarettes (1.3%). Mental health and substance use problems were most strongly correlated with dual and poly‐substance use patterns, regardless of age.Scientific SignificancePrevention and intervention campaigns should focus on multiple product use, as single substance use is uncommon. Alcohol is common in all patterns, suggesting it should also gain more focus in marijuana and tobacco prevention and intervention programs. (Am J Addict 2018;27:491–500)
The association of time of emergency surgery – day, evening or night – with postoperative 30‐day hospital mortality
Authors: Tessler M. J. , Charland L. , Wang N. N. , Correa J. A. 
Published: August 2018

SummaryIt is unclear whether the time of day for emergency surgery is associated with postoperative mortality. We assessed this association in 9319 patients who had emergency surgery as their first surgery at the Jewish General Hospital, Montreal, QC, Canada from April 2010 to March 2015. Of the 7362 (80%) patients with complete data, 168 (2.3%) died within 30 postoperative days. There was no significant association of time of day with postoperative mortality, with adjusted OR (95%CI) of 1.61 (0.96–2.72) for night vs. day, p = 0.07; 1.29 (0.78–2.13) for night vs. evening, p = 0.33; and 1.26 (0.89–1.78) for evening vs. day, p = 0.20. Studies of more patients and more factors, with longer follow‐up, should be carried out to exclude important associations of time of emergency surgery with postoperative mortality and morbidity.
A Foundation Programme educational placement in peri‐operative medicine for older people: mixed methods evaluation
Authors: Rogerson A. , Partridge J. S. L. , Dhesi J. K. 
Published: August 2018

SummaryWe established an innovative Foundation placement in peri‐operative medicine for older patients in response to the need for training in ‘whole patient’ medicine and the challenge of fewer Foundation doctors in acute surgical roles. The placement and underpinning curriculum were co‐designed with junior doctors and other clinical stakeholders. This resulted in a modular design offering acute and community experience and dedicated quality improvement project time. To evaluate the placement we used a mixed methods study based on Kirkpatrick's model of workplace learning. Level 1 (trainee reaction) was evaluated using Job Evaluation Study Tool questionnaires and nominal group technique. Levels 2 and 3 (trainee learning/behaviour) were assessed using a Likert‐style survey mapped to curriculum objectives, e‐portfolio completion, nominal group technique and documentation of completed quality improvement projects and oral/poster presentations. Sixty‐eight foundation trainees underwent the new placement. A similar‐sized ‘control’ sample (n = 57) of surgical Foundation trainees within the same Trust was recruited. The trainees in the peri‐operative placement attained both generic Foundation and specific peri‐operative curriculum competencies, and gave higher job satisfaction scores than trainees in standard surgical placements. The top three ranked advantages from the nominal group sessions were senior support, clinical variety and project opportunities. Universal project completion resulted in high rates of poster and platform presentations, and in sustained service changes at hospital level.
Surgical outcomes of oesophagectomy or gastrectomy due to cancer for patients ≥75 years of age: a single‐centre cohort study
Authors: Klevebro Fredrik , Garritano Stefano , Scandavini Chiara M. , Shetye Alysha , Coppola Alessandro , Kamiya Satoshi , Nilsson Magnus , Lundell Lars , Rouvelas Ioannis 
Published: August 2018

BackgroundThe increasing age of the population and prolonged life expectancy result in a widening of age limit criteria for a variety of surgical procedures. Oesophagectomy and total gastrectomy are complex operations associated with significant risks of post‐operative complications.MethodsThis is a single‐centre cohort study of patients operated with curative intent due to oesophageal or gastric cancer.ResultsFrom 2007 to 2017, 548 patients underwent surgery with curative intent, with 122 patients (22.3%) classified as elderly (≥75 years). There was no difference in total complication rates between the groups. The adjusted odds ratio for 90‐day mortality after oesophageal resection in the elderly group was 3.65 (95% confidence interval (CI): 1.33–10.03) and after gastrectomy was 1.62 (95% CI: 0.55–4.79). The adjusted hazard ratio for 1‐year mortality after oesophagectomy was 2.29 (95% CI: 1.25–4.19), and after gastrectomy the adjusted hazard ratio was 1.48 (95% CI: 0.75–2.92). In the event of a complication with Clavien–Dindo score IIIb or higher, there was a statistically significant increase of 90‐day mortality to over 50% among elderly patients both after oesophagectomy and gastrectomy (50.0% versus 19.8%; P = 0.005 and 57.1% versus 17.4%; P = 0.012, respectively).ConclusionThere is a statistically significant increase in 90‐day mortality after oesophageal and gastric cancer surgery in elderly compared with younger patients. Post‐operative complications with high Clavien–Dindo score in patients undergoing oesophagectomy or gastrectomy, with age ≥75 years, are a dramatic risk factor for post‐operative death.