bluuebunny/crossref_metadata_2025_split huggingface dataset:
A framework to support quality of care for patients with chronic intestinal failure requiring home parenteral nutrition
Authors: Osland Emma J , McGrath Kathleen H , Ali Azmat , Carey Sharon , Daniells Suzie , Angstmann Katerina , Bines Julie , Asrani Varsha , Watson Caitlin , Jones Lynn , De Cruz Peter 
Published: August 2019

AbstractBackground and AimChronic intestinal failure requiring home parenteral nutrition (HPN) is a disabling condition that is best facilitated by a multidisciplinary approach to care. Variation in care has been identified as a key barrier to achieving quality of care for patients on HPN and requires appropriate strategies to help standardize management.MethodThe Australasian Society for Parenteral and Enteral Nutrition (AuSPEN) assembled a multidisciplinary working group of 15 clinicians to develop a quality framework to assist with the standardization of HPN care in Australia. Obstacles to quality care specific to Australia were identified by consensus. Drafts of the framework documents were based on the available literature and refined by two Delphi rounds with the clinician work group, followed by a further two involving HPN consumers. The Oxford Centre for Evidence‐Based Medicine Levels of Evidence was used to assess the strength of evidence underpinning each concept within the framework documents.ResultsQuality indicators, standards of care, and position statements have been developed to progress the delivery of quality care to HPN patients.ConclusionThe quality framework proposed by AuSPEN is intended to provide a practical structure for clinical and organizational aspects of HPN service delivery to reduce variation in care and improve quality of care and represents the initial step towards development of a national model of care for HPN patients in Australia. While developed for implementation in Australia, the evidence‐based framework also has relevance to the international HPN community.
Biological and mechanical complications of angulated abutments connected to fixed dental prostheses: A systematic review with meta‐analysis
Authors: Omori Yuki , Lang Niklaus P. , Botticelli Daniele , Papageorgiou Spyridon N. , Baba Shunsuke 
Published: August 2019

AbstractObjectivesTo evaluate the biological and mechanical complications of angulated abutments on full‐arch and partial jaw rehabilitations with a follow‐up for at least 1 year.MethodsElectronic search was carried out in MEDLINE, EMBASE and Web of Science. Studies published between January 2000 and January 2019 were included. The quality of the included studies was assessed. The data extraction was focused on implant loss, marginal bone loss and mechanical complications, and meta‐analyses were performed for marginal bone loss, mechanical complications and implant failure.ResultsNine studies, three prospective and six retrospective cohort studies were included. They reported on 797 patients that received 4127 implants. The total number of abutments was 4079 of which 1673 were angulated, and 2406 were straight. All abutments were prefabricated. Angulated abutments were associated with increased implant failure rates (two studies; RR = 7.30; 95% CI = 2.79‐19.08) and an effect that was both statistically significant (P < .001) and clinically relevant. Three studies reported differentiated data for mechanical and technical complications at 1 year of follow‐up, being mostly related to the retention screw while screw fracture. Angulated abutments were associated with a statistically significant increase in MBL 1 year after insertion compared to straight abutments (three studies; MD = 0.08 mm; 95% CI = 0.01‐0.14 mm; P = .02), which might be, however, clinically negligible.ConclusionsThe prosthetic complications such as screw loosening and abutment loosening were frequent. After 1 year of follow‐up, implants supporting angulated abutments yielded significantly more marginal bone loss than those supporting straight abutments.
The Experiences of Microaggressions against Women with Visible and Invisible Disabilities
Authors: Olkin Rhoda , Hayward H'Sien , Abbene Melody Schaff , VanHeel Goldie 
Published: August 2019

AbstractOnly two prior studies have examined the experiences of microaggressions for persons with disabilities. Our study was specific to women with both visible and invisible disabilities. Using mixed methods, we asked about the frequency and bothersomeness of microaggression experiences, and in six focus groups with a total of 30 women, we gained more depth about those experiences. Guiding the semistructured focus groups were the 10 domains of microaggressions reported by Keller and Galgay. The women were over age 18 and had either a visible (77%) or hidden disability (33%). Eight (27%) were women of color. Findings supported the previous 10 domains, but we found two additional microaggressions: symptoms not being believed by medical professionals and thus delaying diagnosis, and disability being discounted by others based on looking healthy or young. We make five policy recommendations: (i) curriculum on unconscious bias against women and people with disabilities for medical professionals; (ii) targeted public campaigns to reduce specific types of microaggressions; (iii) changes to public transportation systems to increase accessibility; (iv) journal policy changes to encourage more attention to intersectionality in studies; and (v) greater transparency in psychotherapy about disability‐friendly practices.
Beta‐glucan from Agrobacterium sp. ZX09 improves growth performance and intestinal function in weaned piglets
Authors: Luo Junqiu , Liu Shuli , Yu Bing , He Jun , Mao Xiangbing , Cheng Long , Chen Daiwen 
Published: August 2019

AbstractBeta‐glucan is currently under consideration as an alternative to in‐feed antibiotics. The aim of the study was to investigate Agrobacterium sp. ZX09 beta‐glucan on intestinal morphology, cytokine concentration, mucin expression and microbial populations of weaning piglets. Pigs were randomly assigned to one of five dietary treatments supplemented with 0, 25, 50, 100 and 200 mg/kg beta‐glucan. Data showed an increase in ADG at the 100 mg/kg group (p = .03). A significant increase in villus height and reduction in crypt depth were fund in ileal tissue at the 100 mg/kg inclusion level (p < .05). Dietary supplementation of 100 mg/kg beta‐glucan enhanced IL‐10 concentration (p = .04) and gene expression of MUC1 and MUC2 (p < .05) in the jejunum. Dietary supplementation of 100 mg/kg beta‐glucan provoked the up‐regulation of Lactobacillus counts and down‐regulation of Escherichia coli counts in the caecum (p = .05). Data suggested that improved growth performance in response to beta‐glucan supplementation at 100 mg/kg in weaned piglets may be explained by the improved intestinal function.
Genotype and dietary lysine deficiency affect carcass and muscle amino acid composition of pigs growing from 10 to 25 kg body weight
Authors: Palma‐Granados Patricia , Lara Luis , Seiquer Isabel , Aguilera Jose F. , Nieto Rosa 
Published: August 2019

AbstractAmino acid (AA) composition of body protein is considered constant although there are evidences that AA pattern in pigs may be altered by different factors. Pigs with different body composition and protein deposition rates—like fatty and lean pigs—may differ in AA composition, with possible consequences on their AA requirements. This work investigates effects of genotype and dietary lysine deficiency on AA composition of carcass and muscles of Iberian and Landrace × Large White pigs. Twenty‐eight barrows (10 kg body weight [BW]), 14 from each breed, were used. They were randomly assigned to two experimental diets according to a factorial arrangement (two breeds × two diets). Diets were isonitrogenous and isoenergetic (200 ± 1 g CP/kg dry matter (DM); 14.7 ± 0.1 MJ ME/kg DM) and with identical chemical composition except for lysine concentration (10.9 and 5.20 g lysine/kg DM, for lysine‐adequate (AL) diet and lysine‐deficient (DL) diet respectively). Pigs were individually housed, and daily feed allowance was adjusted on a weekly basis according to BW. Pigs were slaughtered at 25 kg BW. Isoleucine, valine and phenylalanine concentration were higher in carcass protein of Iberian pigs (p < .01). In longissimus muscle, higher concentration of arginine, isoleucine, phenylalanine, lysine and valine (p < .001–p < .05), and lower of methionine (p < .001) were detected in Iberian pigs, whereas phenylalanine, leucine, lysine, threonine and methionine concentration decreased and arginine increased (p < .001–p < .05) when pigs were fed DL diet. Genotype and lysine deficiency effects were moderate in the AA composition of protein of biceps femoris muscle. The results show that AA proportions in protein of carcass and longissimus muscle can be influenced by pig genotype and conditions of lysine shortage. The biceps femoris muscle, with different functional and metabolic properties, shows more constant AA composition than longissimus, which seem to prevail independent from genotype or nutritional challenges.
Hepatic lipidosis: Liver characteristics and acute phase proteins in affected turkeys
Authors: Middendorf Lea , Schmicke Marion , Düngelhoef Kristian , Sieverding Erwin , Windhaus Heinrich , Mischok Dieter , Radko Dimitri , Visscher Christian 
Published: August 2019

AbstractThe hepatic lipidosis (HL) in fattening turkeys is a disease has been known for a long time, but the cause and pathogenesis is still not clarified. A recent study reported unexplained high levels of iron in liver tissue of fattening turkeys suffering from HL. In this study, the iron status, possible infectious or inflammatory influences in form of an acute phase reaction and the analysis of fatty acid pattern in liver tissue of turkeys affected by HL were examined. Three cases of HL on three different fattening turkey farms were investigated during the outbreak of the disease. Clinically affected and non‐affected animals were subjected to a pathological examination, where the diagnosis HL or non‐affected was made. In total, 70 birds were examined (40 with HL, 30 without HL) and blood and liver samples were taken. Additionally, samples from 15 slaughtered birds were taken as a further control group. In liver tissue, the iron content and the content of long‐chain fatty acids were determined; in blood samples, ferritin and transferrin were measured. The iron content in liver tissue was more than three times higher for animals with HL than among non‐affected animals and the control group. The transferrin levels were lowest for animals with HL, highest in the control group and in between for non‐affected animals. The fatty acid pattern in liver tissue of affected animals indicated a shift from polyunsaturated fatty acids to saturated fatty acids and monounsaturated fatty acids compared to the control group and the non‐affected animals. Overall, the non‐affected animals of a flock affected by HL were similar to the healthy animals of the abattoir. The low acute phase protein levels for animals with HL together with high iron contents could indicate a previous malnutrition/starvation period and/or severe liver damage for those animals suffering from HL.
A political‐economic theory of relevance: Explaining climate change inaction
Authors: Gunderson Ryan , Stuart Diana , Houser Matthew 
Published: August 2019

AbstractWhy have societies failed to effectively respond to climate change? We address the question of climate change inaction by (1) examining how an unambiguously ominous report about climate change (IPCC 2018) was made palatable by news media and (2) explaining why climate change is typically unthematized in everyday life. Drawing on Adorno and Schutz, we develop a political‐economic theory of relevance. The imperative to accumulate capital is not only a social‐structural reality but also shapes why particular facts are regarded as relevant in experience (topical relevance) as well as how relevant material is interpreted (interpretative relevance) and acted toward (motivational relevance). Applying this framework, we (1) argue that media popularizations of the IPCC's dire Global Warming of 1.5°C (2018) are constituted by relevance systems conditioned by a capitalist social context and (2) strengthen Ollinaho's (2016) Schutzian explanation for climate change inaction by examining how productive relations and the culture industry perpetuate climate change irrelevance in everyday life. Schutz's framework helps conceptualize the intricacies of ideology and, when revised with Adorno's sociology, shines new light on an old question: the relations between social conditions and knowledge.
Flocculation of Saccharomyces cerevisiae is dependent on activation of Slt2 and Rlm1 regulated by the cell wall integrity pathway
Authors: Sariki Santhosh Kumar , Kumawat Ramesh , Singh Vikash , Tomar Raghuvir Singh 
Published: August 2019

SummaryFlocculation is an essential characteristic of yeast cells required for survival under adverse conditions. The multicellular structure (flocs) of yeast provides a suitable microenvironment to enhance the chances of survival during stress conditions. Although the signaling events triggering flocculation have been studied earlier, molecular mechanisms remain elusive. In the present study, we used flocculating sen1 mutants to identify the mechanism of flocculation. Based on the abnormal cell surface morphology and constitutive phosphorylation of Slt2p in flocculating sen1 mutant cells, we hypothesized if flocculation was regulated by the cell wall integrity (CWI) pathway. Up‐regulation of FLO genes in wild‐type cells was observed upon the activation of CWI pathway either by chemical treatment or by deleting Slt2 phosphatase (Msg5). Our study with Slt2 mutants reveals that the active state of Slt2 is indispensable for flocculation. Deletion of either SLT2 or RLM1 leads to reduced flocculation. Furthermore, we observed overlapping binding sites for Rlm1 and Tup1 at the promoters of almost all the FLO genes. Finally, we show higher Rlm1 and lower Tup1 occupancy at the promoters of FLO1 and FLO5 in flocculating cells. Altogether we demonstrate that CWI MAPK (Slt2) pathway uses a non‐catalytic mechanism to activate the transcription of FLO genes.
Clinical practice guideline for chronic headache 2013
Authors: Araki Nobuo , Takeshima Takao , Ando Naoki , Iizuka Takahiro , Igarashi Hisaka , Ikeda Yukio , Ito Yasuo , Inagaki Mieko , Imamura Keiko , Ohkuma Hirohisa , Ogawa Karin , Kato Yuji , Kikui Shoji , Kitamura Takayuki , Kudo Masako , Kuwabara Kentaro , Gono Yukari , Kowa Hisanori , Saigoh Kazumasa , Sato Shinya , Shibata Koichi , Shibata Mamoru , Shimazu Tomokazu , Shimizu Toshihiko , Suzuki Michiyasu , Takahashi Yuji , Takekawa Hidehiro , Doi Hikaru , Nagata Eiichiro , Nakano Toshiya , Hashizume Masahiro , Hashimoto Shiori , Hamada Junichi , Hirata Koichi , Fujiki Naoto , Fujita Mitsue , Yamane Kiyomi , Wajima Koichi , Watanabe Yuka 
Published: August 2019

AbstractInternational Headache Society published the International Classification of Headache Disorders 2nd Edition (ICHD‐II) in 2004. In response to this development, the “Clinical Practice Guideline for Chronic Headache” was compiled in Japan by the Study Group for Chronic Headache Clinical Practice Guideline Development. In 2006, the book entitled “The Clinical Practice Guideline for Chronic Headache (edited by Japanese Headache Society)” was published as the first edition. As triptans have become widely used, clinical practice for chronic headache has also been changed in Japan and there was a need to revise the first edition. Essentially based on the first edition, the new guideline has added the latest information and presented the concept of international standards of chronic headache care. This guideline included eight chapters and appendix: I. headache: general considerations, II. migraine, III. tension‐type headache, IV. trigeminal autonomic cephalalgias, V. other primary headache disorders, VI. medication‐overuse headache, VII. headaches in children, and VIII. genetics. We have published the second version in Japanese in 2013, but 1 month after we published the original guideline, the International Classification of Headache Disorders 3rd Edition beta version (ICHD‐3beta) was published. We changed this guideline to the new version in English based on ICHD‐3beta. This guideline is the final product of the Committee's efforts in 2015, which was opened in the home page of the Japanese Headache Society. This manuscript was written to show the main part of this guideline as Recommendation of each CQ. Among 121 CQs, only five CQ was selected to present full sentences including not only Recommendation but also other parts.
Gazing into the anthosphere: considering how microbes influence floral evolution
Authors: Rebolleda‐Gómez María , Forrester Nicole J. , Russell Avery L. , Wei Na , Fetters Andrea M. , Stephens Jessica D. , Ashman Tia‐Lynn 
Published: August 2019

SummaryThe flower is the hallmark of angiosperms and its evolution is key to their diversification. As knowledge of ecological interactions between flowers and their microbial communities (the anthosphere) expands, it becomes increasingly important to consider the evolutionary impacts of these associations and their potential eco‐evolutionary dynamics. In this Viewpoint we synthesize current knowledge of the anthosphere within a multilevel selection framework and illustrate the potential for the extended floral phenotype (the phenotype expressed from the genes of the plant and its associated flower microbes) to evolve. We argue that flower microbes are an important, but understudied, axis of variation that shape floral trait evolution and angiosperm reproductive ecology. We highlight knowledge gaps and discuss approaches that are critical for gaining a deeper understanding of the role microbes play in mediating plant reproduction, ecology, and evolution.
The practice of phenomenology: The case of Max van Manen
Authors: Zahavi Dan 
Published: August 2019

AbstractSince its inception, phenomenological philosophy has exerted an influence on empirical science. But what is the best way to practice, use and apply phenomenology in a non‐philosophical context? How deeply rooted in phenomenological philosophy must qualitative research be in order to qualify as phenomenological? How many of the core commitments of phenomenology must it accept? In the following contribution, I will take a closer look at Max van Manen's work. I will argue that van Manen's understanding of and presentation of phenomenology is quite problematic and that his book Phenomenology of Practice rather than amounting to a clear and accessible presentation of the phenomenological method that would make it do‐able to researchers who are not themselves professional philosophers is in fact both abstruse and excessively complicated. I will then turn to nursing, and by taking that as my example, outline a better way to apply and practice phenomenology.
The social utility of community treatment orders: Applying Girard’s mimetic theory to community‐based mandated mental health care
Authors: Jager Fiona , Perron Amélie 
Published: August 2019

AbstractSerious mental illness (SMI) has long posed a dilemma to society. The use of community treatment orders (CTOs), a legal means by which to deliver mandated psychiatric treatment to individuals while they live in the community, is a contemporary technique for managing SMI. CTOs (or a similar legal mechanism) are used in every province in Canada and in many jurisdictions around the world in the care and management of clients with severe and persistent mental illness (most frequently schizophrenia) who have a history of treatment non‐compliance and subsequent relapse. Although there is ongoing controversy around CTOs, their use continues to be on the rise. René Girard's mimetic theory, in which he posits the social utility of the scapegoat mechanism, may shed some light on how established cultural patterns contribute to contemporary responses to SMI: how culture depends on the reproduction of certain narratives, and how these act to shape the identity of those involved. The CTO specifically can be seen to act as a scapegoating mechanism, wherein, by singling out and controlling individuals who appear to threaten social order, social order is restored. This paper reviews Girard's theory, looks at how it has been applied to SMI, and then considers how it may illuminate the social role of the CTO. This examination may provide mental health nurses with insight into the constructed identities of their patients, as well as the role of mental health care within broader cultural narratives.
Affinity proteomics identifies novel functional modules related to adhesion GPCRs
Authors: Knapp Barbara , Roedig Jens , Boldt Karsten , Krzysko Jacek , Horn Nicola , Ueffing Marius , Wolfrum Uwe 
Published: August 2019

AbstractAdhesion G protein–coupled receptors (ADGRs) have recently become a target of intense research. Their unique protein structure, which consists of a G protein–coupled receptor combined with long adhesive extracellular domains, suggests a dual role in cell signaling and adhesion. Despite considerable progress in the understanding of ADGR signaling over the past years, the knowledge about ADGR protein networks is still limited. For most receptors, only a few interaction partners are known thus far. We aimed to identify novel ADGR‐interacting partners to shed light on cellular protein networks that rely on ADGR function. For this, we applied affinity proteomics, utilizing tandem affinity purifications combined with mass spectrometry. Analysis of the acquired proteomics data provides evidence that ADGRs not only have functional roles at synapses but also at intracellular membranes, namely at the endoplasmic reticulum, the Golgi apparatus, mitochondria, and mitochondria‐associated membranes (MAMs). Specifically, we found an association of ADGRs with several scaffold proteins of the membrane‐associated guanylate kinases family, elementary units of the γ‐secretase complex, the outer/inner mitochondrial membrane, MAMs, and regulators of the Wnt signaling pathways. Furthermore, the nuclear localization of ADGR domains together with their physical interaction with nuclear proteins and several transcription factors suggests a role of ADGRs in gene regulation.
Protective Effects of Ginseng Proteins on Photoaging of Mouse Fibroblasts Induced by UVA
Authors: Jiang Rui , Xu Xiaohao , Sun Zhuo , Wang Fei , Ma Rui , Feng Kai , Li Tong , Sun Liwei 
Published: August 2019

AbstractUVA can penetrate dermis and cause functional damage of dermal fibroblasts leading photoaging. Ginseng is a widely used traditional Chinese medicine for skin aging. However, its effects on skin photoaging induced by UVA are not clear. In this study, we isolated ginseng proteins (GP), with molecular weights of 27 kDa and 13 kDa, and found that they alleviated the inhibitory effects of UVA on cell viability and increased percentage of NIH‐3T3 fibroblasts in the S phase of cells cycle. GP also improved cell contraction ability, increased the expression and secretion of CoL‐I, similar to MAPK phosphorylation inhibitors and reduced expression and secretion of MMP‐1, MMP‐2 and MMP‐9 as well as the enzyme activities of MMP‐2 and MMP‐9. They reduced ROS content, DNA damage and 8‐OHdG content, as well as the protein expression of p53, p21 and p16. The levels of p‐ERK, p‐p38 and p‐JNK, p‐c‐Fos and p‐c‐Jun proteins were decreased by GP. Inactivated GP did not inhibit the cellular activity and expression and secretion of CoL‐I irradiated by UVA. The results showed that GP can improve cell viability and contractile function by inhibiting DNA damage and collagen degradation to inhibit the photoaging effects of skin dermal cells caused by UVA.