bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voltammetric Pathways for the Analysis of Ophthalmic Drugs
Authors: Inam Onur , Demir Ersin , Uslu Bengi 
Published: February 2019

Background:This review investigates the ophthalmic drugs that have been studied with voltammetry in the web of science database in the last 10 years.Introduction:Ophthalmic drugs are used in the diagnosis, evaluation and treatment of various ophthalmological diseases and conditions. A significant literature has emerged in recent years that investigates determination of these active compounds via electroanalytical methods, particularly voltammetry. Low cost, rapid determination, high availability, efficient sensitivity and simple application make voltammetry one of the most used methods for determining various kinds of drugs including ophthalmic ones.Methods:In this particular review, we searched the literature via the web of science database for ophthalmic drugs which are investigated with voltammetric techniques using the keywords of voltammetry, electrochemistry, determination and electroanalytical methods.Results:We found 33 types of pharmaceuticals in nearly 140 articles. We grouped them clinically into seven major groups as antibiotics, antivirals, non-steroidal anti-inflammatory drugs, anti-glaucomatous drugs, steroidal drugs, local anesthetics and miscellaneous. Voltammetric techniques, electrodes, optimum pHs, peak potentials, limit of detection values, limit of quantification values, linearity ranges, sample type and interference effects were compared.Conclusion:Ophthalmic drugs are widely used in the clinic and it is important to determine trace amounts of these species analytically. Voltammetry is a preferred method for its ease of use, high sensitivity, low cost, and high availability for the determination of ophthalmic drugs as well as many other medical drugs. The low limits of detection values indicate that voltammetry is quite sufficient for determining ophthalmic drugs in many media such as human serum, urine and ophthalmic eye drops.
Progress in Drug and Formulation Development for the Chemoprevention of Oral Squamous Cell Carcinoma: A Review
Authors: Sarma Himangshu , Jahan Taslima , Sharma Hemanta K. 
Published: February 2019

Background:Cancer is a life-threatening global problem with high incidence rates. Prioritizing the prevention of cancer, chemopreventive agents have drawn much attention from the researchers.Background:This review focuses on the discussion of the progress in the development of chemopreventive agents and formulations related to the prevention of oral cancer.Methods:In this perspective, an extensive literature survey was carried out to understand the mechanism, control and chemoprevention of oral cancer. Different patented agents and formulations have also exhibited cancer preventive efficacy in experimental studies. This review summarizes the etiology of oral cancer and developments in prevention strategies.Results:The growth of oral cancer is a multistep activity necessitating the accumulation of genetic as well as epigenetic alterations in key regulatory genes. Many risk factors are associated with oral cancer. Genomic technique for sequencing all tumor specimens has been made available to help detect mutations. The recent development of molecular pathway and genetic tools has made the process of diagnosis easier, better forecast and efficient therapeutic management. Different chemical agents have been studied for their efficacy to prevent oral cancer and some of them have shown promising results.Conclusion:Use of chemopreventive agents, either synthetic or natural origin, to prevent carcinogenesis is a worthy concept in the management of cancers. Preventive measures are helpful in controlling the occurrence or severity of the disease. The demonstrated results of preventive agents have opened an arena for the development of promising chemopreventive agents in the management of oral squamous cell carcinoma.
Barriers of Nurse Collaboration for the Care of Acute Coronary Syndrome Patients in Emergency Departments: A Pilot Study
Authors: Wihastuti Titin Andri , Rahmawati Ida , Rachmawati Septi Dewi , Lestari Yulia Candra , Kumboyono Kumboyono 
Published: February 2019

Introduction:
Acute Coronary Syndrome (ACS) is a cardiovascular disease that is one of the main causes of death worldwide. Nurse collaboration in Indonesia is still very complex and inadequate. Positive collaboration in providing care for patients with ACS is essential in the practice of nursing services.

Objective:
This study aims to explore the barriers in the implementation of nurses-physicians collaboration for the care of patient with ACS in Emergency Departments (EDs).

Method:
This research is a qualitative survey using purposive sampling. It was conducted on 16 nurses who worked in emergency departments from four general hospitals in East Java, Indonesia. Research data were collected using open-ended questions in semi-structured interviews.

Results:
There were three themes obtained from the data analysis, which include the difference of confidence between senior and junior nurses in ACS actions, limitations in performing professional nursing, and unclear job responsibilities.

Conclusions:
Collaboration of nurses and physicians in emergency departments still faces many problems. It is important to carry out interprofessional education initiations for nursing and medical students, apply peer-mentoring to increase the self-confidence of junior nurse, develop and train the clinical pathway of collaboration between physicians and nurses for the care of ACS patients in EDs.
Agoranomi
Authors: AGORA Redactie 
Published: February 2019

Studentencompetitie IFHP
Recreatie dicht bij huis
VROM met vernieuwde site op internet
Financiering sociale huursector
Onderkant Haagse woningmarkt
IFHP internationale conferentie
Stijging huizenprijs
Rijkshuisvesting
Koopwoningmarkt
Herstructurering bedrijfsterreinen
Congres wonen zonder barrières
NSC congres
ANALISIS PROSES PENGEMBANGAN E-LEARNING BERBASIS MOODLE V.3.1. PADA MATA KULIAH BELAJAR DAN PEMBELAJARAN
Authors: Pradipta Anangga Widya , Wardathi Amy Nilam 
Published: February 2019

Penelitian ini bertujuan untuk menghasilkan media pembelajaran berbantuan internet. Secara khusus penelitian ini bertujuan mendesain dan mengembangkan e-learning berbasis Moodle V.3.1. untuk meningkatkan pemahaman konsep mata kuliah Belajar dan Pembelajaran Program Studi Pendidikan Jasmani Kesehatan dan Rekreasi IKIP Budi Utomo Malang. Langkah yang ditempuh adalah menggunakan prosedur pengembangan yang merupakan kombinasi antara prosedur-prosedur pengembangan dari Alessi dan Trollip. Prosedur pengembangan meliputi 4 tahap utama yaitu perecanaan, desain, pengembangan dan evaluasi sumatif. Teknik pengumpulan data yang digunakan untuk mengolah maupun dan menginterpretasikan hasil tinjauan dan uji coba produk pengembangan bahan ajar yaitu teknik analisis kuantitatif. Analisis data kuantiatif digunakan untuk menguji validitas dan reliabilitas instrumen tes pemahaman konsep. Analisis data dijadikan acuan untuk memperbaiki atau merevisi produk. Hasil pengembangan produk e-learning berupa manajemen pembelajaran online dengan software aplikasi moodle versi 3.1 dengan revisi versi 3.5.7 dengan alamat https://widyapradipta.com. Kelayakan produk e-learning pada aspek materi mendapatkan nilai 76,34 % dan termasuk dalam kategori baik, pada aspek media mendapatkan nilai sebesar 81,83 % dan termasuk dalam kategori sangat baik, aspek respon mahasiswa mendapatkan nilai 88% dalam kategori baik dan pemahaman onsep mahasiswa meningkat 23,6% menjad 83,6% kategori sangat baik.
Una mirada de la cultura organizacional y su incidencia en la competitividad de las organizaciones en el contexto global
Authors: Armas Heredia Isabel Regina 
Published: February 2019

En el campo administrativo, la globalización se entiende como un proceso que ha introducido transformaciones relevantes en el funcionamiento de las organizaciones. Tales cambios, revelan la importancia estratégica adquirida por la dimensión cultural como base del desarrollo organizacional, pues a partir de ésta se promueve un mejoramiento en el desempeño, la productividad y la competitividad empresarial en los mercados globales. En esta dirección, el artículo tiene como objetivo analizar la incidencia de la cultura corporativa en la competitividad de las organizaciones en el contexto global.Para el alcance de este objetivo, metodológicamente se procedió a formular un diseño investigativo basado en la revisión y análisis de literatura en los campos de la globalización, y la cultura organizacional, así como de su incidencia enel desarrollo de las organizaciones. El trabajo se estructuró en tres secciones: en la primera, se aborda el tema de la globalización enfatizando en sus implicaciones en el desarrollo de las organizaciones; en la segunda, se diserta sobre la cultura organizacional como elemento clave que contribuye con el desarrollo de las organizaciones en el contexto global y en la tercera, se presentan las conclusiones destacando la importancia estratégica adquirida por la cultura corporativa como elemento que contribuye con el mejoramiento del desempeño y la competitividad de las organizaciones en los mercados globalizados.
Controle social: realidade de um município do meio oeste catarinense
Authors: Morostica Janaina , Amorim Lilian , Mendes Maria Odete Amorim , Beltrame Vilma 
Published: February 2019

Este artigo tem por objetivo analizar as propostas aprovadas na III Conferência Municipal de Saúde do municipio de Joaçaba, localizado no meio-oeste de Santa Catarina, e relacioná-las com o que foi proposto no Plano Municipal de Saúde realizado no mesmo period. Foi realizado pesquisa documental nos relatórios dos eventos, fornecidos pelo Presidente do Conselho Municipal de Saúde do município. Os dados mostraram que não há relação entre as propostas aprovadas na conferência e o conteúdo do Plano Municipal de Saúde, não têm relação com o eixo no qual foram elencadas e que, linguisticamente, algumas propostas não possuem nexo.Conclui-se que apesar da importância da confência Municipal de Saúde e do Plano Municipal de Saúde para a elaboração de políticas públicas coerentes com as necessidades da população e de ser tão bem embasado legalmente, o controle social, representado pelo conselho e conferência de saúde, ainda encontra dificuldade no desempenho de suas funções.
Contribuição ao conhecimento da ornitofauna do município de Joinville, Santa Catarina, Brasil
Authors: Costa Luciano Souza 
Published: February 2019

O presente estudo foi realizado no município de Joinville, localizado na região nordeste do estado de Santa Catarina, entre Junho de 2012 a novembro de 2014. Durante este período foram levantadas 344 espécies da ornitofauna (187 passeriformes e 157 não passeriformes), distribuídas em 24 ordens e 70 famílias. O número de espécies registradas representa 18% das aves brasileiras e 58% das aves descritas para Santa Catarina. Dentre estas, 31 constam na lista de espécie ameaçadas de extinção para o estado catarinense, indicando a importância do município na preservação deste grupo. No que diz respeito às aves migratórias, foi cadastrado para o município 18 espécies, representando 10,46% das espécies registradas para o Brasil.
Qualidade microbiológica de chá verde (Camellia sinensis) comercializado no município de Concórdia-SC
Authors: Valmorbida Francieli Dalle Laste 
Published: February 2019

As plantas medicinais estão a cada dia sendo mais utilizadas como preventivos de doenças e até mesmo na cura de enfermidades. Diante disso, objetivou-se realizar análises microbioólogicas de chá comercializado em sachê em um supermercado. Colewtou-se uma amostra de chá verde (Camellia sinensis) em um supermercado no município de Concórdia - SC e encaminhou-se para análise em um laboratório localizado no Oeste de Santa Catarina. De acordo com os resultados das análises o nível encontrado de contaminações aeróbios totais foram de 3,0 x 10² UFC/g, para bolores e leveduras o resultado foi de 1,0 x 10² UFC/g. Ainda a amostra apresentou um valor de 1,0 x 10¹ UFC/g para coliformes totais, 1,0 x 10² UFC/g para Staphylococcus coagulase positiva e para Salmonella sp. o resultado foi negativo. Portanto, baseado nos resultados obtidos para contaminação por aeróbios totais, bolores, leveduras e Salmonella sp. a amostra analisada apresenta-se em boas condições para consumo. Para os demais contaminantes a legislação não estabelece os valores máximos permitidos. Acredita-se que sejam necessários treinamentos às pessoas que fazem parte de todo ciclo de produção dos chás para garantir melhor qualidade desses produtos aos consumidores finais.
Monitoramento de fármacos no Ribeirão Quilombo, estado de São Paulo, BR
Authors: Pasquini Nilton Cesar 
Published: February 2019

O monitoramento de fármacos residuais em rios e lagos vêm ganhando atenção dos pesquisadores e da população mundial. Este trabalho monitorou os fármacos antiinflamatório diclofenaco, ibuprofeno, naproxeno, paracetamol, piroxicam e os ?-bloqueadores atenolol, metoprolol, nadolol, propranolol no Ribeirão Quilombo que abrange os municípios de Campinas, Hortolândia, Sumaré, Nova Odessa e Americana, estado de São Paulo-BR, desaguando no Rio Piracicaba no estado de São Paulo. A quantificação foi realizada por cromatografia gasosa (GC-MS/MS), acoplado a um espectrômetro de massas. Avaliando os pontos podemos concluir que o ponto SU/NO apresentou as maiores concentrações. Pouco se sabe sobre o efeito do Atenolol, Metoprolol, Nadolol e Propranolol no meio ambiente aquático e seus efeito ecotoxicológicos. Este estudo mostra que o Ribeirão Quilombo é castigado e consecutivamente leva este castigo para o Rio Piracicaba.
Avaliação de variáveis ao nascimento de recém-nascidos de mães usuárias de drogas
Authors: Santos Carolina Souza , Coelho Patricia Granja , Fonseca Fernando Luiz Affonso , Filipini Rosangela 
Published: February 2019

Estudo observacional, transversal retrospectivo com a amostra de 100 recém-nascidos. A coleta de dados secundários foi realizada por meio de prontuários. Teve como objetivos analisar as condições de nascimento e de saúde de recém-nascidos, no período neonatal precoce, filhos de mães usuárias de drogas lícitas e ilícitas. O uso de drogas licitas e ilícitas pelas gestantes estão associados com o baixo peso ao nascer e poucas consultas de pré-natal (p=0,015 e p=0,0001 respectivamente), com baixo peso ao nascer e poucas consultas de pré-natal e prematuridade (p<0,01 e p=0,000 respectivamente); também com prematuridade e poucas consultas de pré-natal (p<0,001). O uso de fototerapia foi significante com o baixo peso ao nascer e prematuridade (p=0,007 e p<0,0001 respectivamente). Portanto, o consumo de drogas durante o período gestacional altera as condições de nascimento dos bebês, havendo a necessidade de um suporte vital mais complexo, aumentando o risco de morte.
Evaluation of diagnostic coelioscopy in koi (Cyprinus carpio)
Authors: Stevens Brittany N. , Guzman David Sanchez-Migallon , Phillips Kathryn L. , Camus Alvin C. , Soto Esteban 
Published: February 2019

Abstract
OBJECTIVE To describe a technique for endoscopic evaluation of the coelomic viscera of koi (Cyprinus carpio) and to evaluate the ability to visually examine coelomic structures by use of an approach cranial or caudal to the pelvic girdle.
ANIMALS 16 subadult koi.
PROCEDURES Koi were anesthetized with buffered tricaine methanesulfonate. Coelioscopic examination was performed via a ventral midline incisional approach cranial or caudal to the pelvic girdle. A 2.7-mm × 18-cm 30° oblique endoscope within a 4.8-mm operating sheath and infusion of saline (0.9% NaCl) solution was used. Ease of entry into the coelomic cavity and visual examination of structures were scored for each fish. Fish were euthanized 2 or 8 weeks after the procedure, and necropsy was performed.
RESULTS The coelioscopic procedure was tolerated well, and all koi recovered uneventfully. For all fish, ease of entry and visual examination scores of the liver, intestines, gonads, heart, and anterior kidney were satisfactory to excellent. Visual examination of the posterior kidney and swim bladder was satisfactory to difficult, whereas the spleen and gallbladder were not visually identified. No significant differences were noted in entry or visual examination scores between the cranial and caudal approaches or between sexes. Minor complications included mild hemorrhage, rupture of the gonadal capsule, formation of adhesions between the viscera and incision site, and delayed healing of the incision.
CONCLUSIONS AND CLINICAL RELEVANCE Diagnostic coelioscopy of koi appeared to be safe and effective. This procedure could have potential for use in examination of coelomic structures and disease diagnosis.
Comparison of three walkway cover types for use during objective canine gait analysis with a pressure-sensitive walkway
Authors: Kieves Nina R. , Hart Juliette L. , Evans Richard B. , Duerr Felix M. 
Published: February 2019

Abstract
OBJECTIVE To compare the effects of 3 walkway cover types on temporospatial and ground reaction force measurements of dogs during gait analysis with a pressure-sensitive walkway (PSW).
ANIMALS 35 client- and staff-owned dogs (25 nonlame and 10 lame).
PROCEDURES In a crossover study design, all dogs were evaluated at a comfortable walk on a PSW to which 3 cover types (a 0.32-cm-thick corrugated vinyl mat or a 0.32- or 0.64-cm-thick polyvinyl chloride yoga mat) were applied in random order. Temporospatial and ground reaction force measurements were obtained and compared among cover types within the nonlame and lame dog groups.
RESULTS Several variables, including maximum peak pressure, maximum force (absolute and normalized as a percentage of body weight), and vertical impulse (absolute and normalized) differed significantly in most comparisons among cover types for both nonlame and lame dogs. There was no significant difference in maximum force values between the 0.32-cm-thick corrugated vinyl and 0.64-cm-thick polyvinyl chloride cover types for both nonlame and lame dogs.
CONCLUSIONS AND CLINICAL RELEVANCE To the authors’ knowledge, the cover type used during data collection with a PSW is rarely provided in published reports on this topic. The findings in this study suggested that to ensure that PSW data for dogs are collected in a standardized manner, the same cover type should be used during follow-up visits to evaluate clinical outcomes, for the duration of research studies, and at all locations for multi-institutional studies. The cover type should be specified in future PSW studies to allow direct comparisons of findings between studies.
Meeting Physician Compliance Recommendations in the Management of Opioids in Chronic Pain: The Chronic Pain Management Registry (CPMR)
Authors: Langley Paul 
Published: February 2019

In a recent commentary in INNOVATIONS in Pharmacy, details were given on a recently released Chronic Pain Management Registry (CPMR). The CPMR was designed to provide a tracking and audit framework for evaluating claims made for therapy interventions in chronic pain management. At the same time, the CPMR was seen as a key element in monitoring physician and practice compliance with requirements for the prescribing of opioids and other scheduled substances. The purpose of the present commentary is to expand upon the role of the CPMR in the management of opioids in detailing the concordance of the CPMR data collection requirements with the latest recommendations of the American Society of Interventional Pain Physicians (ASIPP) for responsible, safe and effective opioid prescribing in chronic non-cancer pain. Given ongoing concerns with opioid misuse and abuse, the opioid epidemic, physician practices are at risk for what may be judged as poor therapy decisions in evaluating medical necessity and a failure to monitor effectively response to therapy. Adoption of a platform such as the CPMR may, through providing a comprehensive evidence base and tracking capability, support more effective prescribing decisions and adherence to therapy. At the same time, the ability to justify decisions through a CPMR documentation audit may not only alleviate physician concerns if their decisions are challenged but also lead to improved outcomes in the treatment of chronic pain.

Article Type: Commentary
Multiple gene silencing in STAT pathway in K562 cells
Authors: Rajendran Vinod , Deo Sudha S. 
Published: February 2019

Context:
Chronic myeloid leukemia (CML) is characterized by the presence of a fusion oncoprotein BCR-ABL. This mutation imparts a constitutive phosphorylation activity of tyrosine residues in the cellular proteins. One of the targets of BCR-ABL is the STAT5 protein, which when phosphorylated induces gene expression of antiapoptotic proteins such as BCL-XL. The STAT pathway has been targeted in the past by disrupting any one protein only. A multiple gene silencing has never been done in this pathway.

Aim:
The aim of this study was to compare the effects of downregulation of BCR-ABL, STAT5A, STAT5B, and BCL-XL, individually and simultaneously, in human CML cell line (K562 cells) through RNA interference (RNAi). Further, gene expression, inhibition of proliferation, and apoptosis induction were assessed in K562 cells.

Materials and Methods:
K562 cells were transfected with various combinations of small iRNA (siRNA) and the expressions of aforesaid genes were determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. K562 cell proliferation and apoptosis were analyzed using 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide and flow cytometry, respectively. The results were compared through one-way analysis of variance.

Results:
qPCR and western blotting results post-siRNA transfection confirmed the targeted gene suppression and protein reduction in K562 cells. The cell proliferation assay and apoptosis assay revealed that simultaneous gene silencing of BCR-ABL, STAT5A, STAT5B, and BCL-XL had the highest killing effect on K562 cells as compared to knocking down these genes individually or in any other combinations.

Conclusions:
This was the first time it was shown that multiple gene silencing in STAT pathway in CML cell line K562 was better as compared to individual gene silencing.
Nuevas desigualdades urbanas: la apropiación global del patrimonio en los centros históricos mexicanos
Authors: Navarrete Escobedo David 
Published: February 2019

La desigualdad urbana en los centros patrimoniales se ve marcada por la implantación de equipamientos turísticos, culturales y de servicios de alta gama que generan atmósferas aseptizadas y cosmopolitas en espacios históricamente populares y heterogéneos. Esos llamados “rescates” de los centros históricos pueden explicarse en parte por la presencia de poblaciones extranjeras, sean residentes secundarios o turistas. En el siglo xxi, esa presencia esconde procesos complejos que conducen a la acentuación de las desigualdades urbanas bajo la tutela del Estado, del mercado y de actores locales y globales. Es una transformación económica, social, espacial y política que excluye a los habitantes y usuarios tradicionales de los centros históricos de las ciudades mexicanas quienes se ven despojados del goce patrimonial.
Producción y organización espacial de viejas y ‘nuevas’ desigualdades en Quito
Authors: Carrión Fernando , Pinto Juan Pablo 
Published: February 2019

Este trabajo aborda la producción y organización espacial de distintos tipos de desigualdades en Quito, Ecuador. Explica cómo durante los siglos xx y xxi los procesos de urbanización que ha vivido la ciudad han creado nuevas geografías de segregación socioespacial, y analiza otras desigualdades relacionadas con la discriminación de migrantes, grupos lgbti y mujeres, enfatizando su dimensión simbólica (estigmas) y territorial. Plantea que los estudios de desigualdades urbanas deben mostrar su dimensión estructural y multiescalar, diacrónica y sincrónica, material y simbólica, que articule lo nuevo y lo viejo, para dar cuenta de que la ciudad, como un palimpsesto, es un espacio en el que, una y otra vez, se producen y organizan espa- cialmente múltiples desigualdades, aunque no del mismo modo.