bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diving patterns and decompression sickness among South Korean fishery divers
Authors: Cha Su Gang , Byun Young Seok , Jeon Man Joong , Sakong Joon 
Published: January 2019

Abstract

Objectives
We aimed to report the characteristics of diving practice and the incidence of decompression sickness (DCS) among South Korean fishery divers.

Methods
We sent out questionnaires to 215 registered boat owners, and 196 of the fishery divers responded. The questionnaire was comprised of demographical characteristics, diving-related characteristics, and experiences with DCS. DCS was classified into types I and II based on the symptoms.

Results
Their average length of career in fishery diving was 18.1 ± 8.5 years. They were working for 10.8 ± 1.9 months per year. The average bottom time was 74.7 ± 23.3 minutes, the average depth was 23.6 ± 6.8 m, and the average surface interval time was 20.7 ± 12.5 minutes. The incidence of DCS symptoms among the total participants was 84.7%. The incidence increased as working days per month and dives per day increased (P &lt; 0.05). An increased average working depth and a short surface interval time tended to reflect an elevated incidence in the DCS symptoms (P &lt; 0.01). Logistic regression analysis revealed working days per month, dives per day, average bottom time, and rapid ascent as risk factors (P &lt; 0.05).

Conclusions
South Korean fishery divers were shown to be susceptible to DCS because of their repetitive dives for financial reasons. However, they are often beyond the scope of the law. The results of this study suggested that it is necessary to establish the registries of fishery divers.
Randomized controlled trial of Web-based weight-loss intervention with human support for male workers under 40
Authors: Ozaki Itsuko , Watai Izumi , Nishijima Mariko , Saito Nozomu 
Published: January 2019

Abstract

Objectives
Human support can boost weight reduction in Internet-based weight-loss intervention. However, the most effective way to combine human support and the Internet for weight loss is unclear. This study aimed to examine the effects of two weight-loss programs for male workers aged 18-39 that combined different intensities of human support with website support compared to a delayed-intervention group (control group; CG), in a randomized controlled trial.

Methods
Seventy-one participants with overweight or obesity were allocated to one of three 12-week treatment programs. The Standard Support Group (SSG) was provided support via website and two face-to-face group guidance sessions, at the beginning and at the end of the program along with monthly general emails throughout the program. The Enhanced Support Group (ESG) received four remote support sessions based on Supportive Accountability (SA) in addition to the SSG. The CG was provided the same program as SSG after the other two groups had completed the program. The primary outcome was body weight reduction.

Results
ESG participants reduced their weight significantly more than SSG and CG participants (P = 0.038, P &lt; 0.001, respectively), and SSG participants reduced their weight significantly more than CG participants (P = 0.033).

Conclusions
The additional remote human support provided to the participants in the ESG was beneficial for weight loss in male workers. The low-intensity program provided to the SSG was also effective. Further studies with more participants in diverse settings and with participants who are less interested in their health and weight management are needed.
Molecular structure of a 5,10‐methylenetetrahydrofolate dehydrogenase from the silkworm Bombyx mori
Authors: Haque Mohammad R. , Higashiura Akifumi , Nakagawa Atsushi , Hirowatari Aiko , Furuya Shigeki , Yamamoto Kohji 
Published: January 2019

The enzyme 5,10‐methylenetetrahydrofolate dehydrogenase (MTHFD) is essential for the production of certain amino acids (glycine, serine, and methionine) and nucleic acids (thymidylate and purine). Here, we identified a cDNA encoding this enzyme from the silkworm Bombyx mori. The recombinant B. mori MTHFD (bmMTHFD) expressed in Escherichia coli recognized 5,10‐methylenetetrahydrofolate and 5,10‐methenyltetrahydrofolate as substrate in the presence of NADP+ as well as NAD+. The bmMTHFD structure was determined at a resolution of 1.75 Å by X‐ray crystallography. Site‐directed mutagenesis indicated that the amino acid residue Tyr49 contributed to its catalytic activity. Our findings provide insight into the mechanism underlying the activity of MTHFD from B. mori and potentially other insects and may therefore facilitate the development of inhibitors specific to MTHFD as insecticides.
Shape‐Preserved Transformation of Biological Cells into Synthetic Hydrogel Microparticles
Authors: Meyer Kristin C. , Labriola Nicholas R. , Darling Eric M. , Kaehr Bryan 
Published: January 2019

AbstractThe synthesis of materials that can mimic the mechanical, and ultimately functional, properties of biological cells can broadly impact the development of biomimetic materials, as well as engineered tissues and therapeutics. Yet, it is challenging to synthesize, for example, microparticles that share both the anisotropic shapes and the elastic properties of living cells. Here, a cell‐directed route to replicate cellular structures into synthetic hydrogels such as polyethylene glycol (PEG) is described. First, the internal and external surfaces of chemically fixed cells are replicated in a conformal layer of silica using a sol–gel process. The template is subsequently removed to render shape‐preserved, mesoporous silica replicas. Infiltration and cross‐linking of PEG precursors and dissolution of the silica result in a soft hydrogel replica of the cellular template as demonstrated using erythrocytes, HeLa, and neuronal cultured cells. The elastic modulus can be tuned over an order of magnitude (≈10–100 kPa) though with a high degree of variability. Furthermore, synthesis without removing the biotemplate results in stimuli‐responsive particles that swell/deswell in response to environmental cues. Overall, this work provides a foundation to develop soft particles with nearly limitless architectural complexity derived from dynamic biological templates.
Toward the Optimized Spintronic Response of Sn‐Doped IrO2 Thin Films
Authors: Arias‐Egido Eduardo , Laguna‐Marco María Angeles , Piquer Cristina , Boada Roberto , Díaz‐Moreno Sofía 
Published: January 2019

AbstractAmorphous and polycrystalline Sn‐doped IrO2 thin films, Ir1‐xSnxO2, are grown for the first time. Their electrical response and strength of the spin–orbit coupling are studied in order to better understand and tailor its performance as spin current detector material. These experiments prove that the resistivity of IrO2 can be tuned over several orders of magnitude by controlling the doping content in both the amorphous and the polycrystalline state. In addition, growing amorphous samples increase the resistivity, thus improving the spin current to charge current conversion. As far as the spin–orbit coupling is concerned, the system not only remains in a strong spin–orbit coupling regime but it seems to undergo a slight enhancement in the amorphous state as well as in the Sn‐doped samples.
Atomic Ni Anchored Covalent Triazine Framework as High Efficient Electrocatalyst for Carbon Dioxide Conversion
Authors: Lu Chenbao , Yang Jian , Wei Shice , Bi Shuai , Xia Ying , Chen Mingxi , Hou Yang , Qiu Ming , Yuan Chris , Su Yuezeng , Zhang Fan , Liang Haiwei , Zhuang Xiaodong 
Published: January 2019

AbstractElectrochemically driven carbon dioxide (CO2) conversion is an emerging research field due to the global warming and energy crisis. Carbon monoxide (CO) is one key product during electroreduction of CO2; however, this reduction process suffers from tardy kinetics due to low local concentration of CO2 on a catalyst's surface and low density of active sites. Herein, presented is a combination of experimental and theoretical validation of a Ni porphyrin‐based covalent triazine framework (NiPor‐CTF) with atomically dispersed NiN4 centers as an efficient electrocatalyst for CO2 reduction reaction (CO2RR). The high density and atomically distributed NiN4 centers are confirmed by aberration‐corrected high‐angle annular dark field scanning transmission electron microscopy and extended X‐ray absorption fine structure. As a result, NiPor‐CTF exhibits high selectivity toward CO2RR with a Faradaic efficiency of >90% over the range from −0.6 to −0.9 V for CO conversion and achieves a maximum Faradaic efficiency of 97% at −0.9 V with a high current density of 52.9 mA cm−2, as well as good long‐term stability. Further calculation by the density functional theory method reveals that the kinetic energy barriers decreasing for *CO2 transition to *COOH on NiN4 active sites boosts the performance.
Hydrated Layered Vanadium Oxide as a Highly Reversible Cathode for Rechargeable Aqueous Zinc Batteries
Authors: Zhang Ning , Jia Ming , Dong Yang , Wang Yuanyuan , Xu Jianzhong , Liu Yongchang , Jiao Lifang , Cheng Fangyi 
Published: January 2019

AbstractRechargeable aqueous zinc batteries have gained considerable attention for large‐scale energy storage systems because of their low cost and high safety, but they suffer from limitations in cycling stability and energy density with advanced cathode materials. Here, a high‐performance V5O12·6H2O (VOH) nanobelt cathode uniformly located on a stainless‐steel substrate via a facile electrodeposition technique is reported. We show that the hydrated layered VOH cathode enables highly reversible and ultrafast Zn2+ cation (de)intercalation processes, as confirmed by various electrochemical, X‐ray diffraction, X‐ray photoelectron spectroscopy, and transmission electron microscopy analyses. It is demonstrated that the binder‐free VOH cathode can deliver a discharge capacity of 354.8 mAh g−1 at 0.5 A g−1 with a high initial Coulombic efficiency of 99.5%, a high energy density of 194 Wh kg−1 at 2100 W kg−1, and a long cycle life with a capacity retention of 94% over 1000 cycles. In addition, a flexible quasi‐solid‐state Zn–VOH battery is constructed, achieving a reversible capacity of ≈300 mAh g−1 with a capacity retention of 96% after 50 cycles and displaying excellent electrochemical behaviors under different bending states. This work sheds light on the development of rechargeable aqueous zinc batteries for stationary grid storage applications or flexible energy storage devices.
An Indolocarbazole‐Based Thermally Activated Delayed Fluorescence Host for Solution‐Processed Phosphorescent Tandem Organic Light‐Emitting Devices Exhibiting Extremely Small Efficiency Roll‐Off
Authors: Ohisa Satoru , Takahashi Tatsuya , Igarashi Masahiro , Fukuda Hitoshi , Hikichi Tatsuya , Komatsu Ryutaro , Ueki Emi , Pu Yong‐Jin , Chiba Takayuki , Kido Junji 
Published: January 2019

AbstractThe study reports the development of a solution‐processed phosphorescent tandem organic light‐emitting device (OLED) exhibiting extremely small efficiency roll‐off. The OLED comprises two light‐emitting units (LEUs) connected by an interconnecting unit and employs a thermally activated delayed fluorescence host material. One of the most difficult tasks in the fabrication of OLEDs is to form a multilayer structure without dissolving the underlayer during the coating of the upper layer. The developed host materials exhibit high tolerance to methanol. The upper‐layer adjacent to the light‐emitting layer consists of ZnO nanoparticles, which could be dispersed in methanol by improving the preparation method. This results in the successful fabrication of a solution‐processed phosphorescent tandem OLED comprising two LEUs. The maximum external quantum efficiency (EQE) of the tandem device is 22.8%, and the EQE is 21.9% even at a high luminance of 10 000 cd m−2. The suppression of efficiency roll‐off is among the best of those previously reported. Moreover, the operational stability of the tandem device is much higher compared with single‐LEU devices.
Rational Design of Nanoarray Architectures for Electrocatalytic Water Splitting
Authors: Hou Jungang , Wu Yunzhen , Zhang Bo , Cao Shuyan , Li Zhuwei , Sun Licheng 
Published: January 2019

AbstractElectrochemical water splitting is recognized as a practical strategy for impelling the transformation of sustainable energy sources such as solar energy from electricity to clean hydrogen fuel. To actualize the large‐scale hydrogen production, it is paramount to develop low‐cost, earth‐abundant, efficient, and stable electrocatalysts. Among those electrocatalysts, alternative architectural arrays grown on conductive substrates have been proven to be highly efficient toward water splitting due to large surface area, abundant active sites, and synergistic effects between the electrocatalysts and the substrates. Herein, the advancement of nanoarray architectures in electrocatalytic applications is reviewed. The categories of different nanoarrays and the reliable and versatile synthetic approaches of electrocatalysts are summarized. A unique emphasis is highlighted on the promising strategies to enhance the electrocatalytic activities and stability of architectural arrays by component manipulation, heterostructure regulation, and vacancy engineering. The intrinsic mechanism analysis of electronic structure optimization, intermediates' adsorption facilitation, and coordination environments' amelioration is also discussed with regard to theoretical simulation and in situ identification. Finally, the challenges and opportunities on the valuable directions and promising pathways of architectural arrays toward outstanding electrocatalytic performance are provided in the energy conversion field, facilitating the development of promising water splitting systems.
Exploiting Exosomes in Cancer Liquid Biopsies and Drug Delivery
Authors: Fitts Coy Austin , Ji Nan , Li Yusheng , Tan Chalet 
Published: January 2019

AbstractExosomes are cell‐derived nanovesicles that transfer molecular cargo from donor to recipient cells and mediate intercellular communication. Advancement in elucidating the biological capabilities and functionalities of exosomes has revealed the striking roles of exosomes as conveyors of bioactive molecules across the biological barriers. Tumor‐derived exosomes hold great promise to serve as a liquid biopsy tool for cancer diagnosis and prognosis, as large quantities of exosomes are excreted by tumor cells continuously into the circulation, carrying the molecular cargo (DNA, RNA, proteins) reflective of the genetic and signaling alterations in tumor cells. Two inherent characteristics of exosomes offer important opportunities for drug delivery: their superb transcellular permeability and biocompatibility. Exosomes are uniquely capable of encapsulating a variety of payloads and deliver them to the target tissues. This review discusses the potential of tumor‐derived exosomes in cancer liquid biopsies as well as the underlying mechanisms. Furthermore, the recent progress of developing exosomes as highly versatile and efficient drug carriers is also summarized.
Nanoparticle‐Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy
Authors: Chen Qian , Chen Jiawen , Yang Zhijuan , Xu Jun , Xu Ligeng , Liang Chao , Han Xiao , Liu Zhuang 
Published: January 2019

AbstractExternal radiotherapy is extensively used in clinic to destruct tumors by locally applied ionizing‐radiation beams. However, the efficacy of radiotherapy is usually limited by tumor hypoxia‐associated radiation resistance. Moreover, as a local treatment technique, radiotherapy can hardly control tumor metastases, the major cause of cancer death. Herein, core–shell nanoparticles based poly(lactic‐co‐glycolic) acid (PLGA) are fabricate, by encapsulating water‐soluble catalase (Cat), an enzyme that can decompose H2O2 to generate O2, inside the inner core, and loading hydrophobic imiquimod (R837), a Toll‐like‐receptor‐7 agonist, within the PLGA shell. The formed PLGA‐R837@Cat nanoparticles can greatly enhance radiotherapy efficacy by relieving the tumor hypoxia and modulating the immune‐suppressive tumor microenvironment. The tumor‐associated antigens generated postradiotherapy‐induced immunogenic cell death in the presence of such R837‐loaded adjuvant nanoparticles will induce strong antitumor immune responses, which together with cytotoxic T‐lymphocyte associated protein 4 (CTLA‐4) checkpoint blockade will be able to effectively inhibit tumor metastases by a strong abscopal effect. Moreover, a long term immunological memory effect to protect mice from tumor rechallenging is observed post such treatment. This work thus presents a unique nanomedicine approach as a next‐generation radiotherapy strategy to enable synergistic whole‐body therapeutic responses after local treatment, greatly promising for clinical translation.
Reliable Measurement of Perovskite Solar Cells
Authors: Wang Yanbo , Liu Xiao , Zhou Zhongmin , Ru Pengbin , Chen Han , Yang Xudong , Han Liyuan 
Published: January 2019

AbstractPerovskite solar cells (PSCs) have undergone an incredibly fast development and attracted intense attention worldwide owing to their high efficiency and low‐cost fabrication. However, it is challenging to make a reliable measurement of PSCs, which creates great difficulty for researchers to compare and reproduce published results. Herein, the major measurement methods and key factors affecting evaluation of PSCs are summarized, such as hysteresis in current–voltage measurement, calibration of solar simulators for less mismatch in spectra and light intensity, and the area for the calculation of current density and power conversion efficiency. PSCs are also compared with n–i–p or p–i–n structures that exhibit different feedback under the same measurement methods. Finally, a measurement proposal is provided to help researchers obtain reliable measurement results close to those certified by public test centers.
Nonvolatile Memories Based on Graphene and Related 2D Materials
Authors: Bertolazzi Simone , Bondavalli Paolo , Roche Stephan , San Tamer , Choi Sung‐Yool , Colombo Luigi , Bonaccorso Francesco , Samorì Paolo 
Published: January 2019

AbstractThe pervasiveness of information technologies is generating an impressive amount of data, which need to be accessed very quickly. Nonvolatile memories (NVMs) are making inroads into high‐capacity storage to replace hard disk drives, fuelling the expansion of the global storage memory market. As silicon‐based flash memories are approaching their fundamental limit, vertical stacking of multiple memory cell layers, innovative device concepts, and novel materials are being investigated. In this context, emerging 2D materials, such as graphene, transition metal dichalcogenides, and black phosphorous, offer a host of physical and chemical properties, which could both improve existing memory technologies and enable the next generation of low‐cost, flexible, and wearable storage devices. Herein, an overview of graphene and related 2D materials (GRMs) in different types of NVM cells is provided, including resistive random‐access, flash, magnetic and phase‐change memories. The physical and chemical mechanisms underlying the switching of GRM‐based memory devices studied in the last decade are discussed. Although at this stage most of the proof‐of‐concept devices investigated do not compete with state‐of‐the‐art devices, a number of promising technological advancements have emerged. Here, the most relevant material properties and device structures are analyzed, emphasizing opportunities and challenges toward the realization of practical NVM devices.
3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments
Authors: Meng Fanben , Meyer Carolyn M. , Joung Daeha , Vallera Daniel A. , McAlpine Michael C. , Panoskaltsis‐Mortari Angela 
Published: January 2019

AbstractThe development of 3D in vitro models capable of recapitulating native tumor microenvironments could improve the translatability of potential anticancer drugs and treatments. Here, 3D bioprinting techniques are used to build tumor constructs via precise placement of living cells, functional biomaterials, and programmable release capsules. This enables the spatiotemporal control of signaling molecular gradients, thereby dynamically modulating cellular behaviors at a local level. Vascularized tumor models are created to mimic key steps of cancer dissemination (invasion, intravasation, and angiogenesis), based on guided migration of tumor cells and endothelial cells in the context of stromal cells and growth factors. The utility of the metastatic models for drug screening is demonstrated by evaluating the anticancer efficacy of immunotoxins. These 3D vascularized tumor tissues provide a proof‐of‐concept platform to i) fundamentally explore the molecular mechanisms of tumor progression and metastasis, and ii) preclinically identify therapeutic agents and screen anticancer drugs.
Addressable Peptide Self‐Assembly on the Cancer Cell Membrane for Sensitizing Chemotherapy of Renal Cell Carcinoma
Authors: Wang Ziqi , An Hong‐Wei , Hou Dayong , Wang Mandi , Zeng Xiangzhong , Zheng Rui , Wang Lu , Wang Keliang , Wang Hao , Xu Wanhai 
Published: January 2019

AbstractChemotherapy has been validated unavailable for treatment of renal cell carcinoma (RCC) in clinic due to its intrinsic drug resistance. Sensitization of chemo‐drug response plays a crucial role in RCC treatment and increase of patient survival. Herein, a recognition‐reaction‐aggregation (RRA) cascaded strategy is utilized to in situ construct peptide‐based superstructures on the renal cancer cell membrane, enabling specifically perturbing the permeability of cell membranes and enhancing chemo‐drug sensitivity in vitro and in vivo. First, P1‐DBCO can specifically recognize renal cancer cells by targeting carbonic anhydrase IX. Subsequently, P2‐N3 is introduced and efficiently reacts with P1‐DBCO to form a peptide P3, which exhibits enhanced hydrophobicity and simultaneously aggregates into a superstructure. Interestingly, the superstructure retains on the cell membrane and perturbs its integrity/permeability, allowing more doxorubicin (DOX) uptaken by renal cancer cells. Owing to this increased influx, the IC50 is significantly reduced by nearly 3.5‐fold compared with that treated with free DOX. Finally, RRA strategy significantly inhibits the tumor growth of xenografted mice with a 3.2‐fold enhanced inhibition rate compared with that treated with free DOX. In summary, this newly developed RRA strategy will open a new avenue for chemically engineering cell membranes with diverse biomedical applications.