bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental Health Outcomes for Young People Accessing Individual Placement Support Services: A Cohort Study
Authors: Telford Nic , Albrecht Sabina , Wilkin Alice , Watts Carolyn , Rickwood Debra 
Published: November 2024

Objective:Mental health problems and vocational disengagement are often linked for young people in a self-reinforcing cycle. Integrated Individual Placement and Support (IPS) services can help to not only overcome educational/vocational challenges but also improve mental wellbeing.Methods:In a matched cohort study, we compared improvement rates in mental health and wellbeing outcomes for young people aged 15 to 25 who had received at least two integrated IPS services with those who had received standard youth mental health services only. Data came from headspace, Australia’s National Youth Mental Health Foundation. The sample comprised 2128 participants: 544 received integrated IPS services; 1584 received standard mental health services.Results:Four out of five IPS clients (81%) achieved positive outcomes on at least one of three mental health measures, a significantly higher proportion than matched clients who received standard services (75%). Logistic regressions estimated a 22% to 36% higher likelihood of achieving significant improvement for IPS clients. Greater improvements were evident for quality of life and potentially psychosocial functioning, but not psychological distress.Conclusions:Integrating an IPS program within a clinical setting not only achieves positive vocational outcomes, but also supports improvements in quality of life, psychosocial functioning and psychological distress that are greater or equal to the outcomes achieved through standard clinical care.
Government Ownership, Political Regime, and Flipping of IPOs in Pakistan: Evidence from Emerging Market
Authors: Anwar Ayesha , Mohd-Rashid Rasidah , Che-Yahya Norliza , Bouteraa Mohamed , Chekima Brahim 
Published: November 2024

This study investigates how government ownership (state-owned IPOs) and the political regime affect the flipping of IPO shares, as well as the moderating impact of investor demand on the association between the political regime and flipping activity. Ordinary least square was employed to investigate the impact of government ownership and political regime on the flipping of IPO shares. The data set consists of 95 IPO firms listed on the Pakistan Stock Exchange (PSX) during the period of January 2000 to December 2019. The findings of this study reveal that government ownership and a political regime have a positive influence on the flipping of IPO shares, demonstrating the quality that creates liquidity in Pakistan’s IPO market. Furthermore, in Pakistan, investor demand has been reported to moderate the association between the political regime and IPO flipping activity. This research offers valuable insights that may result in abnormal trading behavior or flipping immediately after listing. Likewise, state-owned IPOs and the political regime appear to be more appealing to investors, signaling the firms’ high quality, causing in increased demand and higher levels of flipping. As a result, the government and regulators may devise policies to control unusual trading, ensuring that government investments in the capital market are successful and also that the government’s economic and political objectives are met. Moreover, this research is critical for investors and issuers making investment decisions. JEL Classification: G12, G18, G32.
Influence of Diabetes Mellitus on Neurological Recovery in Older Patients With Cervical Spinal Cord Injury Without Bone Injury: A Retrospective Multicenter Study
Authors: Takeda Kazuki , Watanabe Kota , Nori Satoshi , Yamane Junichi , Kono Hitoshi , Yokogawa Noriaki , Sasagawa Takeshi , Nakashima Hiroaki , Segi Naoki , Funayama Toru , Eto Fumihiko , Furuya Takeo , Yunde Atsushi , Nakajima Hideaki , Yamada Tomohiro , Hasegawa Tomohiko , Terashima Yoshinori , Hirota Ryosuke , Suzuki Hidenori , Imajo Yasuaki , Ikegami Shota , Tonomura Hitoshi , Sakata Munehiro , Hashimoto Ko , Kawaguchi Kenichi , Suzuki Nobuyuki , Uei Hiroshi , Nakanishi Kazuo , Terai Hidetomi , Inoue Gen , Kiyasu Katsuhito , Iizuka Yoichi , Akeda Koji , Funao Haruki , Oshima Yasushi , Kaito Takashi , Yoshii Toshitaka , Ishihara Masayuki , Okada Seiji , Imagama Shiro , Kato Satoshi 
Published: November 2024

Study Design Retrospective study. Objectives To investigate the impact of diabetes mellitus on neurological recovery and determine the relationship between moderate-severe diabetes and neurological recovery in patients with cervical spinal cord injury (CSCI) without bone injury. Methods A retrospective study was conducted on 389 consecutive patients aged ≥65 years with CSCI without bone injury across 33 medical institutes. The patients were divided into a nondiabetic group (n = 270) and a diabetic group (n = 119). Neurological outcomes were compared between the two groups through propensity score matching. The impact of moderate-severe diabetes (defined as hemoglobin A1c ≥ 7.0% or requiring insulin treatment) on neurological recovery was evaluated through multiple linear regression analysis. Results Propensity score matching revealed no significant differences between the diabetic and nondiabetic groups in terms of American Spinal Injury Association (ASIA) impairment scale grade and mean total ASIA motor scores (AMS) at 6 months post-injury. Multiple linear regression analysis indicated that age on admission (B = −0.34; 95% confidence interval [CI], −0.59 to −0.08; P = 0.01), dementia (B = −16.50; 95% CI, −24.99 to −8.01; P < 0.01), and baseline total AMS (B = −0.62; 95% CI, −0.72 to −0.51; P < 0.01) were negative predictors of neurological recovery at 6 months post-injury. The presence of moderate-severe diabetes did not influence neurological recovery at 6 months post-injury. Conclusions Diabetic patients with CSCI without bone injury achieved improvements in neurological function comparable to those of nondiabetic patients. Moderate-severe diabetes did not affect neurological recovery in patients with CSCI without bone injury.
Time Required to Achieve Clinically Significant Outcomes After Anteroinferior Arthroscopic Capsular Release for Shoulder Adhesive Capsulitis
Authors: Pasqualini Ignacio , Rossi Luciano Andrés , Oyem Precious C. , Tanoira Ignacio , Hurley Eoghan T. , Ranalletta Maximiliano 
Published: November 2024

Background: The specific time required to reach clinically significant outcomes for patient-reported outcome measures (PROMs) after arthroscopic capsular release (ACR) for the treatment of shoulder adhesive capsulitis remains unknown. Purposes: To determine the time required to achieve the minimal clinically important difference (MCID) and Patient Acceptable Symptom State (PASS) score thresholds after ACR for visual analog scale (VAS) for pain, American Shoulder and Elbow Surgeons score (ASES), Single Assessment Numeric Evaluation (SANE), and Constant score and to identify patient factors associated with delayed achievement of these clinical benchmarks. Study Design: Case series; Level of evidence, 4. Methods: A prospective analysis was performed of patients who underwent ACR for the treatment of idiopathic shoulder adhesive capsulitis between October 2019 and October2020. Patients completed PROMs preoperatively and at 1, 2, 4, 6, and 12 months postoperatively. Threshold values for MCID and PASS were obtained from previous literature for the VAS, ASES, SANE, and Constant scores. Results: A total of 73 patients were included (mean age, 55.5 ± 9.3 years; body mass index [BMI], 26.6 ± 4.6 kg/m2). By 1-year follow-up, the cumulative percentage of patients achieving the MCID and PASS for VAS, ASES, SANE, and Constant scores was 98.6%, 100%, 100%, and 98.6%, and 95.8%, 91.7%, 98.6%, and 84.9%, respectively. The median time required to reach the MCID thresholds for VAS, ASES, SANE, and Constant scores was 1, 1, 2, and 1 month, respectively. The median time required to reach the PASS thresholds for VAS, ASES, SANE, and Constant scores was 4, 4, 4, and 2 months, respectively. Factors associated with delayed achievement of MCID for SANE included higher BMI (hazard ratio [HR], 0.94; 95% CI, 0.88-0.99) and diabetes (HR, 0.49; 95% CI, 0.2-0.99). Age was associated with delayed achievement of the PASS for VAS. Conclusion: Most patients undergoing ACR achieved clinically significant outcomes within a 4-month timeframe. The majority of patients reached MCID thresholds on outcome measures within 1 to 2 months and achieved satisfactory symptom states within 2 to 4 months postoperatively. By delineating the timeline of patient-perceived benefits, these results provide useful data to set appropriate expectations, guide rehabilitation, and optimize outcomes after ACR.
Fostering timely integrated palliative care in nursing homes through critical companionship: experiences from a Padi-Palli interventional study in France
Authors: Bagaragaza Emmanuel , Umubyeyi Benoite , Leboul Danièle 
Published: November 2024

Background: One of the fundamental pillars of integrating a palliative approach in nursing home care is increasing professional competencies and institutional capacity. However, conventional training designs have been proven to fall short of supporting this integration. This paper details the results of a practice development intervention that used critical companionship as a learning design to facilitate the integration of a palliative approach in the care of nursing home residents in France. Objectives: This study aimed to explore the perceived outcomes of Padi-Palli critical companionship in supporting the integration of a palliative approach in the care of residents in nursing homes in France. Design: Qualitative multiple case study situated within a constructivist theoretic lens. Methods: This qualitative multiple case study is part of a larger interventional mixed-method study. Nurses with palliative care clinical expertise facilitated experiential learning with nursing home professionals for 10 months spread across three phases. At the end of the intervention, a purposive sampling method was used to select professionals from six nursing homes that participated, including leaders and critical companions. Focus groups and individual interviews were used to collect data between February 2023 and March 2024. Data analysis followed Braun and Clarke’s reflexive thematic analysis. Results: Four interrelated themes explained how Padi-Palli critical companionship enhanced the palliative care competencies of professionals, improved nursing home palliative care practices, supported organisational practices for palliative care and facilitated collaborative learning at the bedside. The collaborative and co-creative principles that informed the delivery of the Padi-Palli critical companionship program facilitated a culture shift towards integrating a palliative approach in resident care at individual, team and organisational levels. Conclusion: Critical companionship offers an innovative practice development approach that can support the delivery of timely palliative care for residents in nursing homes. Trial registration: ID-RCB 2020-A01832-37.
Mechanical Properties Optimization and Microstructure Analysis of Pure Copper Heterostructured Laminates via Rolling
Authors: Gao Zhihui , Wang Tao , Zhao Yunlai , Ding Hua , Huang Qingxue 
Published: November 2024

AbstractHeterogeneous metallic structures constitute a novel class of materials with excellent mechanical properties. However, the existing process for obtaining heterostructures from a single material does not meet large-scale industrial requirements. In this study, a pure copper heterostructured laminate (HSL) composed of a surface elongated-grain layer and a central equiaxed-grain layer was fabricated by rolling bonding and annealing. To study the effect of the interface on the mechanical properties of gradient-structured materials, both laminate metal composite (LMC) and non-composite laminate (NCL) were fabricated by cold-rolling pretreatment of the center layer (60% reduction) and cold-rolling bonding of the whole blank (67% reduction). Then, the HSL was obtained by controlling the post-annealing regimes, the microstructure of each layer was optimized, and a larger degree of microstructural heterogeneities, such as grain size, misorientation angle, and grain orientation, was obtained, which resulted in obvious mechanical differences. Tensile tests of the HSL, surface layer, center layer, and NCL specimens revealed that the HSL annealed at 300 °C for 1 h had a significantly higher strength than the center layer and a higher elongation than the surface layer. The HSL had a tensile strength and elongation at fracture of 278.08 MPa and 46.2%, respectively, indicating a good balance of strength and plasticity. The improved properties were primarily attributed to the strengthening or strain hardening due to the inhomogeneous deformation of the heterogeneous layers in the laminate and the mutual constraint acquired by the distinct layers with strong mechanical differences. The HSL had an interfacial bonding strength of 178.5 MPa, which played a vital role in the coordinated deformation of the heterogeneous layers. This study proposes an HSL design method that effectively simplifies the process of obtaining heterostructures in homogeneous materials by controlling the cumulative deformation of the surface and center layers.
The effect of phenotyping, adult selection, and mating strategies on genetic gain and rate of inbreeding in black soldier fly breeding programs
Authors: Slagboom Margot , Nielsen Hanne Marie , Kargo Morten , Henryon Mark , Hansen Laura Skrubbeltrang 
Published: November 2024

Abstract
Background
The aim of this study was to compare genetic gain and rate of inbreeding for different mass selection breeding programs with the aim of increasing larval body weight (LBW) in black soldier flies. The breeding programs differed in: (1) sampling of individuals for phenotyping (either random over the whole population or a fixed number per full sib family), (2) selection of adult flies for breeding (based on an adult individual’s phenotype for LBW or random from larvae preselected based on LBW), and (3) mating strategy (mating in a group with unequal male contributions or controlled between two females and one male). In addition, the numbers of phenotyped and preselected larvae were varied. The sex of an individual was unknown during preselection and females had higher LBW, resulting in more females being preselected.

Results
Selecting adult flies based on their phenotype for LBW increased genetic gain by 0.06 genetic standard deviation units compared to randomly selecting from the preselected larvae. Fixing the number of phenotyped larvae per family increased the rate of inbreeding by 0.15 to 0.20% per generation. Controlled mating compared to group mating decreased the rate of inbreeding by 0.02 to 0.03% per generation. Phenotyping more than 4000 larvae resulted in a lack of preselected males due to the sexual dimorphism. Preselecting both too few and too many larvae could negatively impact genetic gain, depending on the breeding program.

Conclusions
A mass selection breeding programs in which the adult fly is selected based on their larval phenotype, breeding animals mate in a group and sampling larvae for phenotyping at random over the whole population is recommended for black soldier flies, considering the positive effect on rates of genetic gain and inbreeding. The number of phenotyped and preselected larvae should be calculated based on the expected female weight deviation to ensure sufficient male and female candidates are selected.
Exploring public perception and utilization of medication home delivery services in the United Arab Emirates: a cross-sectional study
Authors: Jirjees Feras , Othman Amna M , Odeh Mohanad , AlObaidi Hala , Kharaba Zelal , Adhari Hawraa , Elshenawy Menna , Almaazmi Fatima , Bashi Yahya H Dallal , Aldeyab Mamoon A , Al-Azayzih Ahmad , Farha Rana Abu , Eissa Nermin , Alzoubi Karem H 
Published: November 2024

Abstract
Introduction
The Medication Home Delivery (MHD) service from community pharmacies involves the safe and efficient delivery of pharmaceuticals (prescription and non-prescription medications), and health products directly to the patient’s/consumer’s home. There are several issues encountered by the users of the MHD service that have an impact on their satisfaction with the service. The study aimed to assess the public’s perceptions of the MHD service in the United Arab Emirates (UAE), their willingness to utilize it, and the practical use of the service.

Method
A cross-sectional exploratory study was conducted in the UAE using a validated online survey. The inclusion criteria were adults residing in the UAE. Statistical analysis was performed to identify the association between the variables, the service use, and the level of service efficiency.

Results
A total of 556 participants filled out the survey, with 69.4% of them using the service. The majority of participants were females (75.9%) and aged less than 40 years old (71.6%). Three variables showed a statistically significant association with the use of the MHD service (P < 0.05): the participant’s educational level, their medical/health background, and the frequency of visits to community pharmacies. The most common issues raised were receiving the wrong order, delay in delivery, and paying delivery fees. Most participants agreed that the MHD service reduces the risk of exposure during pandemics, serves the elderly, serves disabled people, makes it more comfortable for parents with children at home, and reduces overcrowding in health facilities, as well as the MHD service making pharmacy services more efficient.

Conclusion
The study indicated positive perceptions among the public in the UAE towards the MHD service. However, there was a concern that this service may diminish the communication between pharmacists and patients, which potentially minimizes the amount of information received by patients regarding their treatments.
General health and social outcomes 50 years after exposure to antenatal betamethasone: follow-up of a randomised controlled trial
Authors: Walters Anthony G. B. , Gamble Greg D. , Crowther Caroline A. , Dalziel Stuart R. , Eagleton Carl L. , McKinlay Christopher J. D. , Milne Barry J. , Harding Jane E. 
Published: November 2024

Abstract

Background

Antenatal corticosteroids are recommended for women at risk of preterm birth from 24 to 34 weeks’ gestation as they reduce neonatal morbidity and mortality, but evidence regarding their long-term effects on offspring is limited. This study assessed general health and social outcomes 50 years after antenatal exposure to corticosteroids.

Methods
We assessed 424 adult offspring of women who participated in the first randomised, double-blind, placebo-controlled trial of antenatal betamethasone for the prevention of neonatal respiratory distress syndrome. The first 717 mothers received two intramuscular injections of betamethasone (6 mg betamethasone sodium phosphate and 6 mg betamethasone acetate) or placebo given 24 h apart and the subsequent 398 received two injections of double dose betamethasone (12 mg betamethasone sodium phosphate and 12 mg betamethasone acetate) or equivalent volume of placebo. Follow-up included a health questionnaire and consent for access to administrative data sources. Outcome categories included mental health (depression, anxiety, bipolar affective disorder, schizophrenia and treatment or hospital admission for any mental health disorder), general health (chronic kidney disease, cancer diagnosis, bone fracture, oral health, allergies, functional difficulties and physical activity) and social outcomes (educational attainment, employment and criminal convictions). Investigators remained blinded to treatment allocation. Analyses were adjusted for gestational age at entry, sex and clustering.

Results
We assessed 424 adult offspring (46% of survivors; mean [SD] age 49.3 [1.0] years; 212 [50%] female). There was no difference in mental health, general health and social outcomes between those exposed to betamethasone and those exposed to placebo, with the exception that osteoporotic site fracture in adulthood was more likely to have occurred in the betamethasone group compared with placebo (adjusted relative risk 1.57, 95% CI 1.00, 2.48, p = 0.05). No dose–effect relationship was evident and there was no difference in the proportion with at least one fracture. Follow-up rate and lack of in-person assessments were the main limitations.

Conclusions
There is no evidence that antenatal corticosteroids have clinically important effects on general health and social outcomes up to 50 years of age.
Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies
Authors: Räuber Saskia , Schulte-Mecklenbeck Andreas , Willison Alice , Hagler Ramona , Jonas Marius , Pul Duygu , Masanneck Lars , Schroeter Christina B. , Golombeck Kristin S. , Lichtenberg Stefanie , Strippel Christine , Gallus Marco , Dik Andre , Kerkhoff Ruth , Barman Sumanta , Weber Katharina J. , Kovac Stjepana , Korsen Melanie , Pawlitzki Marc , Goebels Norbert , Ruck Tobias , Gross Catharina C. , Paulus Werner , Reifenberger Guido , Hanke Michael , Grauer Oliver , Rapp Marion , Sabel Michael , Wiendl Heinz , Meuth Sven G. , Melzer Nico 
Published: November 2024

Abstract
Background
Immune dysregulation is a hallmark of autoimmune diseases of the central nervous system (CNS), characterized by an excessive immune response, and primary CNS tumors (pCNS-tumors) showing a highly immunosuppressive parenchymal microenvironment.

Methods
Aiming to provide novel insights into the pathogenesis of CNS autoimmunity and cerebral tumor immunity, we analyzed the peripheral blood (PB) and cerebrospinal fluid (CSF) of 81 autoimmune limbic encephalitis (ALE), 148 relapsing–remitting multiple sclerosis (RRMS), 33 IDH-wildtype glioma, 9 primary diffuse large B cell lymphoma of the CNS (CNS-DLBCL), and 110 controls by flow cytometry (FC). Additionally, an in-depth immunophenotyping of the PB from an independent cohort of 20 RRMS and 18 IDH-wildtype glioblastoma patients compared to 19 controls was performed by FC combined with unsupervised computational approaches.

Results
We identified alterations in peripheral and intrathecal adaptive immunity, mainly affecting the T cell (Tc) but also the B cell (Bc) compartment in ALE, RRMS, and pCNS-tumors compared to controls. ALE, RRMS, and pCNS-tumors featured higher expression of the T cell activation marker HLA-DR, which was even more pronounced in pCNS-tumors than in ALE or RRMS. Glioblastoma patients showed signs of T cell exhaustion that were not visible in RRMS patients. In-depth characterization of the PB revealed differences mainly in the T effector and memory compartment between RRMS and glioblastoma patients and similar alterations in the Bc compartment, including atypical Bc, CD19+CD20− double negative Bc, and plasma cells. PB and CSF mFC together with CSF routine parameters could reliably differentiate ALE and RRMS from pCNS-tumors facilitating early diagnosis and treatment.

Conclusions
ALE, RRMS, and pCNS-tumors show distinct but partially overlapping changes mainly in HLA-DR+ Tc, memory Tc, exhausted Tc, and Bc subsets providing insights into disease pathogenesis. Moreover, mFC shows diagnostic potential facilitating early diagnosis and treatment.

Graphical Abstract