bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of anthropometric indicators to screen for clustered cardiometabolic risk factors in children and adolescents
Authors: de Quadros Teresa Maria Bianchini , Gordia Alex Pinheiro , Andaki Alynne Christian Ribeiro , Mendes Edmar Lacerda , Mota Jorge , Silva Luciana Rodrigues 
Published: December 2018

AbstractBackgroundAnthropometric indicators are associated with cardiometabolic risk factors (CMRF), but there is no consensus as to which indicator is the most suitable to screen for clustered CMRF. This study aimed to evaluate the utility of five anthropometric indicators to screen for clustered CMRF in children and adolescents.MethodsA cross-sectional study was conducted in 1139 schoolchildren aged 6–17 years from Northeastern Brazil. Body weight, height, waist circumference (WC) and subscapular (SSF) and triceps skinfold thickness (TSF) were measured. Body mass index (BMI) and waist-to-height ratio (WHtR) were calculated. The following CMRF were evaluated: elevated total cholesterol, low high-density lipoprotein-cholesterol (HDL-C), elevated low-density lipoprotein-cholesterol (LDL-C), high triglyceride concentration, hyperglycemia and high blood pressure. The participants were categorized into no CMRF, 1 CMRF, 2 CMRF and ≥3 CMRF. Receiver operating characteristic (ROC) curves were constructed to assess the accuracy of the anthropometric indicators in predicting CMRF for age group and sex.ResultsPoor associations were observed between the anthropometric indicators and 1 CMRF (accuracy of 0.49–0.64). The indicators showed moderate associations with 2 CMRF (accuracy of 0.57–0.75) and ≥3 CMRF (accuracy of 0.59–0.79). In general, TSF exhibited the worst performance in predicting CMRF, followed by WHtR. The highest accuracies were observed for BMI, WC and SSF, with no significant difference between these indicators.ConclusionsThe routine use of BMI, WC and SSF as epidemiological screening tools for clustered CMRF in childhood and adolescence should be encouraged.
Familial ROBO1 deletion associated with ectopic posterior pituitary, duplication of the pituitary stalk and anterior pituitary hypoplasia
Authors: Scala Marcello , Accogli Andrea , Allegri Anna Maria Elsa , Tassano Elisa , Severino Mariasavina , Morana Giovanni , Maghnie Mohamad , Capra Valeria 
Published: December 2018

Abstract

Background
The genetic causes of abnormal pituitary development have been extensively studied in the last few years. ROBO1 is involved in neurogenesis and axon guidance. Loss-of-function variants in ROBO1 have been associated with pituitary stalk interruption syndrome (PSIS), suggesting that its haploinsufficiency could impair the guidance of hypothalamic axons to the pituitary gland leading to developmental abnormalities.

Case presentation
We report a 4.5-year-old girl with anterior pituitary hypoplasia and pituitary stalk duplication in the ventral-dorsal direction. Her father had a similar pituitary phenotype, characterized by anterior pituitary hypoplasia combined with ectopic posterior pituitary. Comparative genomic hybridization (CGH) microarray analysis identified a 343.7 kb deletion of 3p12.3 encompassing ROBO1 in both individuals.

Conclusions
We report the first familial ROBO1 deletion in two individuals with peculiar pituitary anomalies, including the rare pituitary stalk duplication in the ventral-dorsal direction. These findings widen the spectrum of the phenotypes associated with ROBO1 haploinsufficiency and support its role in human pituitary development.
Stimulus Context and Reward Contingency Induce Behavioral Adaptation in a Rodent Tactile Detection Task
Authors: Waiblinger Christian , Wu Caroline M. , Bolus Michael F. , Borden Peter Y. , Stanley Garrett B. 
Published: December 2018

Behavioral adaptation is a prerequisite for survival in a constantly changing sensory environment, but the underlying strategies and relevant variables driving adaptive behavior are not well understood. Many learning models and neural theories consider probabilistic computations as an efficient way to solve a variety of tasks, especially if uncertainty is involved. Although this suggests a possible role for probabilistic inference and expectation in adaptive behaviors, there is little if any evidence of this relationship experimentally. Here, we investigated adaptive behavior in the rat model by using a well controlled behavioral paradigm within a psychophysical framework to predict and quantify changes in performance of animals trained on a simple whisker-based detection task. The sensory environment of the task was changed by transforming the probabilistic distribution of whisker deflection amplitudes systematically while measuring the animal's detection performance and corresponding rate of accumulated reward. We show that the psychometric function deviates significantly and reversibly depending on the probabilistic distribution of stimuli. This change in performance relates to accumulating a constant reward count across trials, yet it is exempt from changes in reward volume. Our simple model of reward accumulation captures the observed change in psychometric sensitivity and predicts a strategy seeking to maintain reward expectation across trials in the face of the changing stimulus distribution. We conclude that rats are able maintain a constant payoff under changing sensory conditions by flexibly adjusting their behavioral strategy. Our findings suggest the existence of an internal probabilistic model that facilitates behavioral adaptation when sensory demands change.SIGNIFICANCE STATEMENTThe strategy animals use to deal with a complex and ever-changing world is a key to understanding natural behavior. This study provides evidence that rodent behavioral performance is highly flexible in the face of a changing stimulus distribution, consistent with a strategy to maintain a desired accumulation of reward.
A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety
Authors: Pomrenze Matthew B. , Tovar-Diaz Jorge , Blasio Angelo , Maiya Rajani , Giovanetti Simone M. , Lei Kelly , Morikawa Hitoshi , Hopf F. Woodward , Messing Robert O. 
Published: December 2018

The central amygdala (CeA) is important for fear responses to discrete cues. Recent findings indicate that the CeA also contributes to states of sustained apprehension that characterize anxiety, although little is known about the neural circuitry involved. The stress neuropeptide corticotropin releasing factor (CRF) is anxiogenic and is produced by subpopulations of neurons in the lateral CeA and the dorsolateral bed nucleus of the stria terminalis (dlBST). Here we investigated the function of these CRF neurons in stress-induced anxiety using chemogenetics in male rats that express Cre recombinase from aCrhpromoter. Anxiety-like behavior was mediated by CRF projections from the CeA to the dlBST and depended on activation of CRF1 receptors and CRF neurons within the dlBST. Our findings identify a CRFCeA→CRFdlBSTcircuit for generating anxiety-like behavior and provide mechanistic support for recent human and primate data suggesting that the CeA and BST act together to generate states of anxiety.SIGNIFICANCE STATEMENTAnxiety is a negative emotional state critical to survival, but persistent, exaggerated apprehension causes substantial morbidity. Identifying brain regions and neurotransmitter systems that drive anxiety can help in developing effective treatment. Much evidence in rodents indicates that neurons in the bed nucleus of the stria terminalis (BST) generate anxiety-like behaviors, but more recent findings also implicate neurons of the CeA. The neuronal subpopulations and circuitry that generate anxiety are currently subjects of intense investigation. Here we show that CeA neurons that release the stress neuropeptide corticotropin-releasing factor (CRF) drive anxiety-like behaviors in rats via a pathway to dorsal BST that activates local BST CRF neurons. Thus, our findings identify a CeA→BST CRF neuropeptide circuit that generates anxiety-like behavior.
Pharmacokinetic interaction between mitotane and etoposide in adrenal carcinoma: a pilot study
Authors: Jouinot Anne , Royer Bernard , Chatelut Etienne , Moeung Sotheara , Assié Guillaume , Thomas-Schoemann Audrey , Bertherat Jérôme , Goldwasser François , Blanchet Benoit 
Published: December 2018

Background
The combination of mitotane and platinum-etoposide chemotherapy is a front-line treatment in metastatic adrenocortical carcinoma (ACC), although this regimen shows limited efficacy. Pharmacokinetic drug–drug interaction between mitotane, a strong CYP3A4 inducer, and etoposide, which is a substrate of CYP3A4, may contribute to chemoresistance. The aim of this pilot study was to assess the pharmacokinetic interaction between mitotane and etoposide in ACC patients.

Methods
Five consecutive ACC patients treated with platinum etoposide (120–150 mg/m2 day 1–2–3 at cycle 1), with or without concomitant mitotane, were included. In the absence of limiting toxicity, a dose escalation of etoposide was proposed since cycle 2. Plasma etoposide concentrations were measured using liquid chromatography at 0, 4 and 24 h after each infusion. Clearance and area under the curve (AUC) of etoposide were determined at each cycle.

Results
Patients received two to six chemotherapy cycles, in association with mitotane (N = 4) or after mitotane discontinuation (N = 1). Etoposide clearance was two-fold higher with concomitant mitotane (4.95 L/h) than after mitotane discontinuation (2.53 L/h, P = 0.014), and 2.5-fold higher than that in reference population not treated with mitotane (1.81 L/h). Etoposide dose escalation was performed in four patients under mitotane, resulting in two minor tumor responses and one severe toxicity (febrile aplasia) at dose of 300 mg/m2/day. Tumor response was associated with higher etoposide AUC (267.3 vs 188.8 mg.h/L, P = 0.04).

Conclusion
A drug–drug interaction between mitotane and etoposide may contribute to the low efficacy of platinum-etoposide chemotherapy. This pilot study suggests further a potential benefit of increasing etoposide dose in ACC patients receiving mitotane.
Pre-operative right ventricular echocardiographic parameters associated with short-term outcomes and long-term mortality after CABG
Authors: Chowdhury Mohammed Andaleeb , Cook Jered M. , Moukarbel George V. , Ashtiani Sana , Schwann Thomas A. , Bonnell Mark R. , Cooper Christopher J. , Khouri Samer J. 
Published: December 2018

Abstract

Background: This analysis aims to assess the prognostic value of pre-operative right ventricular echocardiographic parameters in predicting short-term adverse outcomes and long-term mortality after coronary artery bypass graft (CABG).

Methods: Study design: Observational retrospective cohort. Pre-operative echocardiographic data, perioperative adverse outcomes (POAO) and long-term mortality were retrospectively analyzed in 491 patients who underwent isolated CABG at a single academic center between 2006 and 2014.

Results: Average age of enrolled subjects was 66 ± 11.5 years with majority being male (69%). 227/491 patients had 30 days POAO (46%); most common being post-operative atrial fibrillation (27.3%) followed by prolonged ventilation duration (12.7%). On multivariate analysis, left atrial volume index ≥ 42 mL/m2 (LAVI) (OR (95% CI): 1.98 (1.03-3.82), P = 0.04), mitral E/A > 2 (1.97 (1.02-3.78), P = 0.04), right atrial size >18 cm2 (1.86 (1.14-3.05), P = 0.01), tricuspid annular plane systolic excursion (TAPSE) <16 mm (1.8 (1.03-3.17), P = 0.04), right ventricular systolic pressure (RVSP) =36 mmHg (pulmonary hypertension) (1.6 (1.03-2.38), P = 0.04) and right ventricle myocardial performance index (RVMPI) > 0.55 (1.58 (1.01-2.46), P = 0.04) were found to be associated with increased 30-day POAO. On 3.5-year follow-up, cumulative survival was decreased in patients with myocardial performance index (MPI) ≥ 0.55 (log rank: 4.5, P = 0.034) and in patients with mitral valve E/e′ ≥ 14 (log rank: 4.9, P = 0.026).

Conclusion: Pre-operative right ventricle dysfunction (RVD) is associated with increased perioperative complications. Furthermore, pre-operative RVD and increased left atrial pressures are associated with long-term mortality post CABG.
Diseño e integración del recurso multimedia «Mine-ducation» en educación primaria: Valoraciones aportadas por expertos
Authors: Etchegaray Centeno María Celia , Duarte Hueros Ana María , Guzmán Franco María Dolores 
Published: December 2018

El estudio describe y analiza el proceso que seguido para la evaluación y validación a través de la técnica del juicio de expertos de un novedoso recurso educativo implementado en Educación Primaria: «Mine-ducation». Se trata de un sistema multimedia en línea que tiene en cuenta las inteligencias múltiples y los estilos de aprendizaje del alumnado para brindar la posibilidad de una enseñanza individualizada. Se emplea un método no experimental, utilizando la técnica de juicio de expertos utilizando las entrevistas individuales semiestructuradas para la recogida de datos y se aborda el análisis siguiendo de forma sistemática, secuencial y ordenada, los procesos recomendados en el método comparativo constante para la codificación abierta, axial y selectiva. Los resultados obtenidos permiten identificar que los expertos entrevistados perciben la herramienta como una aliada en la docencia, entre otros motivos porque facilita el proceso de enseñanza-aprendizaje acorde con las necesidades del alumnado y las nuevas tendencias pedagógicas en relación a las TIC. Además, es valorado por proveer información sobre el perfil cognitivo de cada estudiante, facilitando una educación más individualizada. Las dificultades que los docentes encuentran para implementar este recurso nos hacen pensar que los centros escolares se encuentran en proceso de adaptación metodológica y tecnológica.
¿Es posible la formación de personas éticas y comprometidas en la universidad? La asignatura de Educación para la paz y la igualdad en los Grados de Magisterio
Authors: Torrego Egido Luis , Martínez Scott Suyapa , Sonlleva Velasco Miriam 
Published: December 2018

RESUMENLa universidad debería formar estudiantes bien informados, dotados de sentido crítico y comprometidos con la transformación social desde una ética universal basada en la solidaridad y en el bien común. Sin embargo, en la universidad actual predomina una visión utilitarista de la formación. La asignatura Educación para la paz y la igualdad se imparte en los Grados de Educación Infantil y Educación Primaria de la Universidad de Valladolid. Su finalidad es contribuir a la formación de personas éticas y comprometidas. En este artículo se analizan la potencialidad y los logros de esa asignatura. Mediante un estudio de caso en el que se utilizan entrevistas, observación no participante, cuestionarios, análisis de documentos y análisis de producciones del alumnado de la asignatura, se evalúa la valoración por parte de los estudiantes y la influencia que ejerce en ellos, así como los aprendizajes que genera. Se constata una mayor sensibilización, una mejora en la comprensión de la realidad global y el descubrimiento de estrategias didácticas para trabajar la paz y la igualdad en la escuela, pero sigue existiendo una actitud pasiva en buena parte del alumnado. Se precisa una educación contra el conformismo y la indiferencia.Palabras Clave: Formación inicial, Compromiso ético, Estudio de caso, Modelos de universidad.ABSTRACTThe university should educate well-informed students, endowed with critical sense and committed to social transformation from a universal ethic based on solidarity and the common good. However, at the current university, a utilitarian vision of education predominates. The subject Education for peace and equality is been taught in the Degrees of Early Childhood Education and Primary Education at the University of Valladolid. Its purpose is contributing to educate ethical and committed people. This paper analyzes the potentiality and achievements of this subject. Through a case study using interviews, non-participant observation, questionnaires, analysis of documents and that of student productions for the subject, assessment made by the students and their influence on them are evaluated, as well as the learnings generated by it. There is a greater awareness, an improvement in the understanding of the globalreality and the discovery of didactic strategies to work for peace and equality at school, but a passive attitude remains in many of the students. An education against conformism and indifference is needed.Keywords: Initial formation, Ethical commitment, Case study, University models.
Long-term outcome of the laparoscopic repair of hiatus hernia
Authors: Burikov M. A. , Skazkin I. V. , Shulgin O. V. , Kinyakin A. I. , Sokirenko I. A. 
Published: December 2018

Presently, the improvement in the quality of life of patients who underwent a laparoscopic surgical repair of hiatus hernia and the absence of the gastroesophageal reflux disease (GERD) recurrence are the basic characteristics of the surgical treatment. In this connection, further perfection of the tactics and techniques of the surgical GERD treatment becomes an important problem of modern surgery.
Here, we present a comparative analysis of the remote results of the surgical treatment of 159 patients with GERD-complicated hiatus hernia. The patients were divided into two groups, depending on the technique of the performed endosurgical treatment. The first group consisted of patients operated via the standard laparoscopic Nissen fundoplication. In the second group, we included those patients who underwent surgical treatment using a modified procedure of Nissen fundoplication with the formation of a non-tension cuff (RF patent No. 2529415 of 27.09.2014).
Evaluation of the results, based on the survey questionnaires Gerd-Q, GSRS, SF-36 and the data of instrumental research methods, was performed 1 to 5 years post-treatment.
The treatment of the GERD-complicated hiatus hernia patients with application of the technique of forming a non-hanging fundoplication cuff shows the best long-term results: the incidence of the reflux syndrome and signs of hyperfunction of the fundoplication cuff is lower. The revealed differences coincide with the data of the Gerd-Q and GSRS questionnaires, as well as the life quality estimation by the SF-36 questionnaire. The developed techniques do not require application of sophisticated technical skills and re-equipment and may be recommended for the practical use in the everyday practice in surgical hospitals of all levels.
The publications of François Crépin (1830-1903). An annotated chronological list
Authors: Hoste Ivan , Hanquart Nicole 
Published: December 2018

As the author of a flora that was used by generations of amateur and professional botanists and, later in his career, of numerous studies on the taxonomy of genus Rosa, François Crépin has a place among the leading botanists in Belgium in the nineteenth century. See for more information about his life and career, among others, Errera & Durand (1906), Lebrun (1968), Diagre-Vanderpelen (2011) and Hoste & Diagre-Vanderpelen (2018).
Effects of Nitrogen Fixing and Phosphate Solubilizing Bacteria on Growth and Bulbs Production of Tulip Cultivars
Authors: PARLAKOVA KARAGÖZ Fazilet , DURSUN Atilla 
Published: December 2018

Objective: This study was under taken to determine the effects of nitrogen fixing and phosphate solubilizing bacteria on plant development, number of bulb and quality of bulb of some tulipcultivars.Materials and Methods: The research was conducted in open field conditions, in 2013. Pink Impression, Blue Aimable and Golden Parade varieties of Tulipa gesneriana L. were used as plant materials. Tulip bulbs were inoculated by four different bacterial formulations comprising Pantoea agglomerans RK-79, Pantoea agglomerans RK-92, Bacillus megaterium TV-91C, Bacillus subtilis TV-17C, Bacillus megaterium TV-3D, Paenibacillus polymyxa TV-12E, Bacillus megaterium TV-6D, Pseudomonas putida TV-42A bacteria strains.Results: According to research results, significant results were determined based on among the applications and varieties. According to applications, average maximum number mother bulbs was obtained from cultivar of Golden Parade while average maximum number bulblet was observed in Blue Aimable cultivar. The highest average maximum bulbet was obtained from formulation C application in Blue Aimable cultivar.Conclusion: As a result of the study, it has been concluded that the bacterial formulation applications especially formulation C (RK-79 + RK-92 + TV-3D + TV-12E) application increased inthe number of bulbs and quality of the cultivars.
ECO-CIDADANIA EM LUIS ALBERTO WARAT: UM OLHAR PARA O FUTURO DOS REFUGIADOS AMBIENTAIS
Authors: Bertaso Joao Martins , Seger Franciele 
Published: December 2018

<p>A presente pesquisa versa sobre a eco-cidadania como possibilidade de enfrentar a crise ecológica e suas consequências, dentre as quais destaca-se a massa de refugiados ambientais, pessoas forçadas ao deslocamento devido à ocorrência de desastres naturais. Nesse sentido, objetiva-se descrever, por meio do método dedutivo, da técnica de pesquisa bibliográfica e do procedimento histórico, os desafios e violações sofridas pelos refugiados ambientais, já que lhes é negado reconhecimento e proteção jurídica internacional. A partir disso, estudar a eco-cidadania em Luis Alberto Warat, a qual envolve ecologia, cidadania, política e subjetividade, elementos que, interligados, são capazes de alterar o atual estilo de vida, restaurando a relação homem-natureza, a fim de assegurar um direito ao amanhã, que dê condições de existência a um futuro comum. A eco-cidadania visa o reconhecimento do Outro (ser humano e natureza) nas suas diferenças, valendo-se do amor como cuidado. Por isso, ela contribui tanto para a formação de um sujeito ecológico, que se torne consciente da necessidade de preservação do meio onde vive, como para o reconhecimento de pessoas excluídas como os refugiados ambientais. </p>
Aspergillus penicillioides Speg. Implicated in Keratomycosis
Authors: MACHOWICZ-MATEJKO EULALIA , FURMAŃCZYK AGNIESZKA , ZALEWSKA EWA DOROTA 
Published: December 2018

Abstract
The aim of the study was mycological examination of ulcerated corneal tissues from an ophthalmic patient. Tissue fragments were analyzed on potato-glucose agar (PDA) and maltose (MA) (Difco) media using standard laboratory techniques. Cultures were identified using classical and molecular methods. Macro- and microscopic colony morphology was characteristic of fungi from the genus Aspergillus (restricted growth series), most probably Aspergillus penicillioides Speg. Molecular analysis of the following rDNA regions: ITS1, ITS2, 5.8S, 28S rDNA, LSU and β-tubulin were carried out for the isolates studied. A high level of similarity was found between sequences from certain rDNA regions, i.e. ITS1-5.8S-ITS2 and LSU, what confirmed the classification of the isolates to the species A. penicillioides. The classification of our isolates to A. penicillioides species was confirmed also by the phylogenetic analysis.