bluuebunny/crossref_metadata_2025_split huggingface dataset:
CERTOLIZUMAB PEGOL IN THE TREATMENT OF TAKAYASU ARTERITIS: THE FIRST EXPERIENCE AND PROSPECTS
Authors: Novikov P. I. , Smitienko I. O. , Sokolova M. V. , Moiseev S. V. 
Published: July 2018

Certolizumab pegol (CZP) is the only pegylated biological agent (BA) that does not contain an Fc fragment, which minimizes its transplacental transfer. Takayasu arteritis mostly occurs in reproductive-aged women.Objective: to evaluate the efficacy and safety of CZP used to treat standard immunosuppressive therapy-resistant Takayasu arteritis.Subjects and methods. The retrospective study enrolled 6 female patients aged 18 to 35 years with Takayasu arteritis who received CZP. The median disease duration before BA usage was 66 months (24 to 204 months). The median duration of immunosuppressive therapy prior to CZP treatment was 92 months (14 to 132 months). All the female patients had taken glucocorticoids and methotrexate before and during CZP therapy. Only four patients had received two to five immunosuppressive drugs at different times prior to BA administration. Three patients had previously used other BAs. The disease activity was determined by the National Institute of Health (NIH) criteria. The Indian Takayasu Clinical Activity Score (ITAS2010) was used. The disease activity was recorded in all the patients prior to CZP therapy.Results and discussion. The median duration of CZP treatment was 17 months (6 to 24 months). The median erythrocyte sedimentation rate after CZP usage decreased from 22.5 to 10.5 mm/h; the median C-reactive protein level dropped from 7.8 to 0.39 mg/dl (p<0.05), the median daily dose of prednisolone was reduced from 20 to 8.75 mg (p<0.05). All the patients achieved complete remission an average of 4 months after starting CZP therapy. Three patients were still in remission after 12–24 months. One relapse of the disease was recorded following 24 months. ITAS2010 reduced from 1–4 to 0 in five patients and to 2 in one patient with recurrence. There was a good tolerance in five female patients. The adverse events were herpes labialis in two cases, community-acquired pneumonia in one case, and postoperative abscess in one case too.Conclusion. CZP in Takayasu arteritis was shown to be an effective drug for remission induction and maintenance. The presented results of the first experience in treating this disease with CZP are indicative of its promising further investigation as a steroid-sparing drug in patients with refractory vasculitis. One of the important advantages of CZP is its supposed high safety throughout pregnancy.
Are Basic Capital Versus Basic Income Debates Too Narrow?
Authors: Prabhakar Rajiv 
Published: July 2018

Abstract
Basic income and basic capital are two common ideas for redesigning distribution. Basic income provides people with a regular income from government. Basic capital provides people with a lump-sum grant. An important part of scholarly debate concentrates on the merits of basic income versus basic capital. This paper claims that these debates are too narrow. First, current debates overlook the way that a chief inspiration for both ideas, Thomas Paine, wanted basic capital and basic income to be complements not substitutes. Second, it is more instructive to compare basic capital or basic income with a wider set of alternatives than with each other. Widening the debates would benefit the discussion of a basic capital or basic income.
A Posteriori Stopping Criteria for Optimized Schwarz Domain Decomposition Algorithms in Mixed Formulations
Authors: Ali Hassan Sarah , Japhet Caroline , Kern Michel , Vohralík Martin 
Published: July 2018

AbstractThis paper develops a posteriori estimates for domain decomposition methods with optimized Robin transmission conditions on the interface between subdomains. We choose to demonstrate the methodology for mixed formulations, with a lowest-order Raviart–Thomas–Nédélec discretization, often used for heterogeneous and anisotropic porous media diffusion problems. Our estimators allow to distinguish the spatial discretization and the domain decomposition error components. We propose an adaptive domain decomposition algorithm wherein the iterations are stopped when the domain decomposition error does not affect significantly the overall error. Two main goals are thus achieved. First, a guaranteed bound on the overall error is obtained at each step of the domain decomposition algorithm. Second, important savings in terms of the number of domain decomposition iterations can be realized. Numerical experiments illustrate the efficiency of our estimates and the performance of the adaptive stopping criteria.
Exotic crossed products and the Baum–Connes conjecture
Authors: Buss Alcides , Echterhoff Siegfried , Willett Rufus 
Published: July 2018

Abstract
We study general properties of exotic crossed-product functors and characterise those which extend to functors on equivariant

C
*

C^{*}

-algebra categories based on correspondences.
We show that every such functor allows the construction of a descent in K
K-theory and we use
this to show that all crossed products by correspondence functors of K-amenable groups are K
K-equivalent.
We also show that for second countable groups the minimal exact Morita compatible crossed-product functor
used in the new formulation of the Baum–Connes conjecture by Baum, Guentner and Willett ([‘Expanders, exact crossed products, and the Baum–Connes conjecture’,
preprint 2013])
extends to correspondences when restricted to separable G-

C
*

C^{*}

-algebras.
It therefore allows a descent in K
K-theory for separable systems.
Your body is our black box: Narrating nations in second-person fiction by Edna O’Brien and Jennifer Egan
Authors: Newman Daniel Aureliano 
Published: July 2018

Abstract
For a century, the disorienting effects of second-person narration have seemed peculiarly well suited to representing the experiential confusions and political contradictions of inhabiting a female body in times of national crisis. This essay examines such effects in Edna O’Brien’s A pagan place and Jennifer Egan’s “Black box,” very different narratives that similarly exploit the deictic and ontological uncertainties of second-person address. Second person in O’Brien’s novel participates in its depiction of a sexually naïve rural Irish girl confronting the conflicting pressures of enforced chastity and reproductive futurism in the name of the Irish State. Emphasis is placed on the narrative’s unusual use of past-tense second-person narration and its intriguing overlap with O’Brien’s nonfictional writings. In Egan’s story, the protean and multivocal second person suggests a sinister fusion of individual and governmental agency, effected through the protagonist’s cybernetically-enhanced body. The result is a deceptively simple critique of post-9/11 American foreign policy as an extension of paternalism and patriarchy in the domestic sphere. The patterns investigated in this paper shed light on other recent uses of the second person in other experimental narratives concerned with identity, self-formation among disenfranchised individuals, and resistance to political and cultural oppression.
Nonlinearity and focalisation in Attila Janisch’sMásnap
Authors: Csönge Tamás 
Published: July 2018

AbstractThe essay’s aim is to examine the relationship between perspective and nonlinear temporal structure in Attila Janisch’s 2004 film,Másnap, which is loosely based on Alain Robbe-Grillet’sLe Voyeur(1955). My analysis revolves around the understanding of two important narratological distinctions, that between a nonlinear presentation of events and a paradoxical plot, and that between narrative focalizalization and textual focalization. According to David Bordwell, the most widespread definition of linearity is when the successive events of A, B and C are presented in the narrative in their chronological order. Any other form of their presentation results in a nonlinear narrative. ButMásnapis a special type of narrative, which highlights the limitation of such traditional dichotomies, because a consistent order of events cannot be reconstructed. Many critics tried to grasp the core of the film’s narrative by trying to put together the original timeline of events, relying on false indicators of logic and coherence, while they failed to recognize the narrative’s real rhetorical purpose in preventing a consistent and unambiguous plot to be established. The narrative’s complexity lies in the fact that both assumptions – that it depicts asubjective experience of timeanda storyworld with strange temporality– are necessary to explain the film’s unusual, fragmented structure and interpret its events. I point out how the film requires us to reinterpret the meanings attached to the familiar techniques of continuity editing and how it converts the practices of the early Nouveau Roman, which marginalizes traditional plot-structures, the notion of character, and conventional descriptions of objects, to interact with a subjective vision governed by a fictional mind.
Die Regulation der hippokampalen Informationsenkodierung durch metabotrope Glutamatrezeptoren
Authors: Manahan-Vaughan Denise 
Published: July 2018

Zusammenfassung
Der Hippokampus unterstützt den Erwerb von sowohl räumlichen Repräsentationen als auch von langfristigem räumlichen Gedächtnis. Dies wird ermöglicht durch das Zusammenwirken dreier physiologischer Prozesse, nämlich der Organisation und dem Transfer von Informationen mittels neuronaler Oszillationen, der Erstellung von kontextabhängigen räumlichen Karten mittels Ortszellen und der langfristigen Speicherung räumlicher Lernerfahrung mittels synaptischer Plastizität. Alle drei Prozesse werden durch das glutamaterge System ermöglicht. Die Bindung von Glutamat an ionotrope Glutamatrezeptoren ermöglicht sowohl die schnelle exzitatorische synaptische Transmission (über AMPA-Rezeptoren) als auch die Initiierung einer synaptischen Langzeitspeicherung (über NMDA-Rezeptoren). Aber Glutamat bindet sich auch an metabotrope Glutamat-Rezeptoren (mGlu). Diese Rezeptoren tragen nicht nur zur Stabilität der hippokampalen Enkodierung und der Langlebigkeit der synaptischen Plastizität bei, sie können auch die synaptische Informationsspeicherung unabhängig von der Aktivierung des NMDA-Rezeptors unterstützen und sind für Erwerb und Erhalt des Langzeitgedächtnisses wichtig.
On the relation between the true and sample correlations under Bayesian modelling of gene expression datasets
Authors: Jacobovic Royi 
Published: July 2018

Abstract
The prediction of cancer prognosis and metastatic potential immediately after the initial diagnoses is a major challenge in current clinical research. The relevance of such a signature is clear, as it will free many patients from the agony and toxic side-effects associated with the adjuvant chemotherapy automatically and sometimes carelessly subscribed to them. Motivated by this issue, several previous works presented a Bayesian model which led to the following conclusion: thousands of samples are needed to generate a robust gene list for predicting outcome. This conclusion is based on existence of some statistical assumptions including asymptotic independence of sample correlations. The current work makes two main contributions: (1) It shows that while the assumptions of the Bayesian model discussed by previous papers seem to be non-restrictive, they are quite strong. To demonstrate this point, it is shown that some standard sparse and Gaussian models are not included in the set of models which are mathematically consistent with these assumptions. (2) It is shown that the empirical Bayes methodology which was applied in order to test the relevant assumptions does not detect severe violations and consequently an overestimation of the required sample size might be incurred. Finally, we suggest that under some regularity conditions it is possible that the current theoretical results can be used for development of a new method to test the asymptotic independence assumption.
A Hippo Pathway-Related GCK Controls Both Sexual and Vegetative Developmental Processes in the Fungus Sordaria macrospora
Authors: Radchenko Daria , Teichert Ines , Pöggeler Stefanie , Kück Ulrich 
Published: July 2018

Abstract
The supramolecular striatin-interacting phosphatases and kinases (STRIPAK) complex is conserved from yeast to human, and regulates a variety of key biological processes. In animals, this complex consists of the scaffold protein striatin, the protein phosphatase 2A, and kinases, such as germinal center kinase (GCK) III and GCKIV family members, as well as other associated proteins. The STRIPAK complex was identified as a negative regulator of the Hippo pathway, a large eukaryotic signaling network with a core composed of a GCK and a nuclear Dbf2-related kinase. The signaling architecture of the Hippo core resembles the fungal septation initiation network (SIN) that regulates cytokinesis in fission yeast as well as septation in filamentous fungi. In the filamentous model fungus Sordaria macrospora, core components of the STRIPAK complex have been functionally described and the striatin homolog PRO11 has been shown to interact with the GCK SmKIN3. However, the exact role of SmKIN3 in fungal development has not yet been fully elucidated. Here, we provide comprehensive genetic and functional analysis of SmKIN3 from S. macrospora. Using deletion mutants and site-directed mutagenesis, along with phenotypic and phylogenetic analysis, we provide compelling evidence that SmKIN3 is involved in fruiting body formation, hyphal fusion, and septation. Strains carrying the ATP-binding mutant SmKIN3K39R, as well as a double-deletion strain lacking SmKIN3 and the core STRIPAK subunit PRO11, also revealed severe developmental defects. Collectively, this study suggests that SmKIN3 links both the SIN and STRIPAK complex, thereby regulating multiple key cellular processes.
La integración de la extensión, la docencia y la investigación universitarias: el caso del Proyecto Team-UNA de la Sede Regional Brunca
Authors: Barrantes Elizondo Lena , Valverde Marín Evelyn , Quesada Estrada Emanuel 
Published: July 2018

Recibido 04/12/2017 Aceptado 27/03/2018En la búsqueda de la calidad en la relación extensión-docencia-investigación se evidencia la necesidad de estar en constante replanteamiento de estrategias de integración. El Proyecto Team-UNA de la Sede Regional Brunca nació en el año 2010 con el propósito de trabajar con el sector estudiantil del Ciclo Diversificado de la Educación General Básica, para el mejoramiento de su calidad de vida a través de la oferta de tutorías en Inglés gratuitas, logrando así vincular la docencia y la extensión. Este proyecto busca gestionar la participación de estudiantes de la carrera Bachillerato en la Enseñanza del Inglés como tutores y tutoras de estudiantes de secundaria procedentes de colegios públicos de la región. Este estudio tiene como objetivo dar a conocer la experiencia generada, como base para fortalecer el proceso de enseñanza y aprendizaje vivencial. La sistematización se llevó a cabo a través de la recolección de experiencias de los actores principales por medio de su participación en grupos focales a lo largo del desarrollo del proyecto. Como resultado, se llega a la conclusión de que Team-UNA es un catalizador de aprendizaje vivencial que fomenta el análisis crítico, la toma de decisiones y la resolución de problemas, elementos necesarios que respaldan la integración de la docencia, la extensión y la investigación educativas.
Adults’ Perceptions of Nicotine Harm to Children
Authors: Kemp Catherine B. , Spears Claire Adams , Pechacek Terry F. , Eriksen Michael P. 
Published: July 2018

BACKGROUND:
Given the changing landscape of tobacco products in recent years, the array of products through which children could be exposed to nicotine has grown substantially. Thus, it is particularly important to understand adults’ perceptions of the harms of nicotine to children and to identify any sociodemographic factors related to inaccurate risk perceptions.

METHODS:
Data were drawn from 2015 to 2016 US nationally representative surveys (n = 11 959). Using multinomial logistic regression analyses, we examined whether race, sex, education, tobacco product use, and having a minor child in the home are associated with the level of perceived harmfulness of nicotine to children.

RESULTS:
Although the majority of respondents characterized nicotine as “definitely harmful” to children, there were notable subgroup differences. Compared with women, men had significantly lower odds of characterizing nicotine as “definitely harmful” to children. Tobacco product users had significantly lower odds of endorsing “definitely harmful” or “don’t know” than nonusers. African American non-Hispanic individuals, Hispanic individuals, and “other” non-Hispanic individuals had significantly lower odds of endorsing “definitely harmful” or “maybe harmful” than white individuals.

CONCLUSIONS:
Although most adults perceive nicotine exposure as harmful for children, there are important differences based on sex, racial and/or ethnic background, and tobacco use status. The results reveal the need for public health efforts to better understand and target inaccurate risk perceptions among specific subgroups.
Factores asociados a la susceptibilidad al consumo de cigarrillo en escolares de 10 y 11 años en Cartagena, Colombia
Authors: Cogollo Zuleima , De la Hoz Fernando Pio 
Published: July 2018

Objetivo Determinar los factores asociados a la susceptibilidad al consumo de cigarrillo en escolares de 10 y 11 años de sexto grado de la ciudad de Cartagena, Colombia.Método Se realizó un estudio analítico observacional transversal, con una muestra no probabilística por conveniencia de 289 escolares de 10 y 11 años de sexto grado de colegios públicos de Cartagena, Colombia. La información se recolectó a través de la ficha demográfica, el inventario de consumo de cigarrillo y actitudes frente al mismo de la Encuesta Mundial Sobre Tabaquismo en jóvenes (Emta_Joven), escala de susceptibilidad a la persuasión hacia el consumo, la escala Apgar familiar, Rosenberg para autoestima y la escala de Zung de ansiedad.Resultados participaron 289 estudiantes, media para la edad 10,9 (DE=0,25); 157 (54,3%) fueron mujeres y 132 (45,7%) fueron hombres. La frecuencia de experimentación con cigarrillo alguna vez en la vida fue 20 (6,9%) y la alta susceptibilidad al consumo de cigarrillo fue 61 (21,1%). Los factores que se asociaron a alta susceptibilidad a la persuasión para consumo de cigarrillo fueron: ser del sexo masculino (OR de 2,81; IC95%: 1,56-5,08), disfunción familiar (OR: 2,29; IC95%: 1,23-4,24) y haber fumado alguna vez en la vida (OR: 3,41; IC95%: 1,34- 8,67).Conclusiones la susceptibilidad al consumo de cigarrillo en estudiantes de sexto grado se asoció a ser del género masculino, la disfuncionalidad familiar y haber fumado alguna vez en la vida.
Malaria complicada en el Chocó: hallazgos clínicos y comparación de datos con el sistema de vigilancia
Authors: Murillo Palacios Olga Lucia , Pedroza Carmen , Bolaños Claudia , Del Toro Elvis , Cubillos Joddy , Chaparro Pablo , Mosquera Miladys 
Published: July 2018

Objetivos Describir las características epidemiológicas y clínicas de casos de malaria complicada y establecer la concordancia de esta información con el sistema de vigilancia.Metodología La información se obtuvo de historias clínicas de casos informados en 2011 en el sistema de vigilancia atendidos en el Hospital San Francisco. Se seleccionó una muestra de 62 historias clínicas de 113 casos. Para definir que la historia clínica correspondía a malaria complicada se tuvo en cuenta la presencia de gota gruesa positiva con uno o más criterios de complicación, según la guía clínica nacional y la ficha del sistema de vigilancia. La significancia estadística se determinó con el Chi2 y el estadístico Kappa.Resultados El 37% de los casos presentó una complicación, el 63% presentaron dos o más complicaciones. Las principales complicaciones fueron trombocitopenia y anemia severa, seguido de complicación hepática, hiperparasitemia, insuficiencia renal y malaria cerebral. En tres de los 54 casos, se usó el Artesunato intravenoso. Se utilizó Quinina en el 59,2% de los casos. La comparación de variables demográficas y especie parasitaria entre las fuentes utilizadas no muestra diferencias significativas, pero el acuerdo general de tipo de complicación fue casi nulo. Las principales complicaciones reportadas no aparecen en la ficha de notificación.Discusión Es necesario continuar otros estudios con el fin de contribuir en la caracterización clínica de la malaria en el Departamento y las intervenciones de manejo. Se recomiendan ajustes a la ficha para fortalecer el análisis y la toma de decisiones.
The imperative of integrating empirical and theoretical considerations when developing policy responses to Internet-gaming disorder
Authors: Wegmann Elisa , Brand Matthias 
Published: July 2018

This commentary proposes an integrative approach of theoretical and empirical considerations when developing policy responses to Internet-gaming disorder and when evaluating their efficacy. It complements the overview by Király et al. (2018) about preventive and treatment programs by referring to a lack of inclusion of internal factors, such as individual aspects and cognitions, and missing empirical evidence. This commentary claims the integration of current research addressing individual predisposing and maintaining factors in order to evaluate existing programs and to enhance the exchange between actors including policy. This integrative approach has the potential to develop successful preventive strategies, which could be implemented realistically and socially responsible.
SOCIAL INFANTILITY OF RUSSIAN YOUTH: SPECIFICITY OF SCIENTIFIC DISCURSE
Authors: DEMIDENKO A. S. 
Published: July 2018

Nowadays, the study of infantility is becoming more urgent, and the phenomenon of social infantilism itself is a problem of our time, since more and more representatives of the younger generation do not aspire to take responsibility for solving questions concerning their life path. As a result, the level of social immaturity is growing. The aim of the article is to cover interdisciplinary studies of social infantility and social maturity. The urgency of the work is determined by the insufficient knowledge of infantility in sociological knowledge, as well as the lack of clear methods of preventing the infantilism of Russian youth. This article examines different approaches to the definition of social infantility in Russia and abroad. The signs of this phenomenon are described. The meaning of the concept of social maturity is revealed, its criteria are given, which are necessary for revealing the signs of social infantility. The paper describes a number of directions in the study of the social infantility of the youth of Russia at the present stage. Thus, on the basis of a brief analysis of articles touching on the issues of social infantility and social maturity, it can be concluded that there is no single definition of these concepts. It can also be said that in the world practice the study of infantility and maturity receives not only a theoretical foundation, but also a broad orientation to practice.
Sylviculture tropicale en forêt dense africaine (Partie 4)
Authors: Catinot René 
Published: July 2018

L’article présente la quatrième partie de l’étude sur la sylviculture en forêt dense africaine. Dans cet article, l’auteur compare les différentes méthodes employées dans les forêts tropicales humides à la lumière des résultats de recherche exposés dans le précédent article. Il conclut que, excepté pour les méthodes « Limba » et « Okoumé », le principal facteur limitant le succès des plantations semble être le manque de lumière arrivant jusqu’au niveau du sol. Sur la base de cette observation fondamentale et d’autres considérations techniques, il propose des changements aux méthodes conventionnelles, avec la perspective d’améliorer leurs chances de succès.