bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of White Matter Hyperintensities With Short-Term Outcomes in Patients With Minor Cerebrovascular Events
Authors: Zerna Charlotte , Yu Amy Y.X. , Modi Jayesh , Patel Shiel K. , Coulter Jonathan I. , Smith Eric E. , Coutts Shelagh B. 
Published: March 2018

Background and Purpose—
White matter lesions (WML) are associated with cognitive decline, increased stroke risk, and disability in old age. We hypothesized that superimposed acute cerebrovascular occlusion on chronic preexisting injury (leukoaraiosis) leads to worse outcome after minor cerebrovascular event, both using quantitative (volumetric) and qualitative (Fazekas scale) assessment, as well as relative total brain volume.

Methods—
WML volume assessment was performed in 425 patients with high-risk transient ischemic attack (TIA; motor/speech deficits >5 minutes) or minor strokes from the CATCH study (CT and MRI in the Triage of TIA and Minor Cerebrovascular Events to Identify High Risk Patients). Complete baseline characteristics and outcome assessment were available in 412 patients. Primary outcome was disability at 90 days, defined as modified Rankin Scale score of >1. Secondary outcomes were stroke progression, TIA recurrence, and stroke recurrence. Analysis was performed using descriptive statistics and regression models including interaction terms.

Results—

Median age was 69 years, 39.8% were female. Sixty-two patients (15%) had unfavorable outcome with disability at 90 days (modified Rankin Scale score >1). Higher Fazekas scores were strongly correlated with higher WML volume (
r
=0.79). Both higher Fazekas score and higher WMH volume were associated with disability at 90 days in univariate regression (odds ratio 1.22; 95% confidence interval, 1.04–1.43 and odds ratio, 1.25 per milliliter increase; 95% confidence interval, 1.02–1.54, respectively) but not with stroke progression, TIA recurrence, or stroke recurrence. In multivariable-adjusted analyses, additive interaction terms were associated with unfavorable outcome (adjusted odds ratio 3.99, 95% confidence interval, 1.87–8.49).

Conclusions—
Our data suggest that quantitative and qualitative WML assessments are highly correlated and comparable in TIA/minor stroke patients. WML burden is associated with short-term outcome of patients with good prestroke function in the presence of intracranial stenosis/occlusion.
Quantitative Arterial Tortuosity Suggests Arteriopathy in Children With Cryptogenic Stroke
Authors: DeVela Gabriel , Taylor J. Michael , Zhang Bin , Linscott Luke L. , Chen Alan M. , Karani Kunal B. , Furthmiller Andrew , Leach James L. , Vadivelu Sudhakar , Abruzzo Todd 
Published: March 2018

Background and Purpose—
Quantitative arterial tortuosity (QAT) is a ratio of vessel length between 2 points to the shortest linear distance between same points. QAT has been reported as an imaging biomarker of arteriopathy in pediatric arterial ischemic stroke (AIS) because of dissection and transient cerebral arteriopathy. We sought to determine whether QAT abnormalities are present in other subtypes of pediatric AIS.

Methods—
Children with AIS-absent conventional biomarkers of arteriopathy and case–controls who underwent magnetic resonance angiography were classified by stroke mechanism. The primary study population consisted of cryptogenic AIS cases. AIS with bow hunter physiology and cardiogenic emboli were also evaluated. AIS because of nontraumatic dissection served as positive controls. Patients without vascular risk factors served as negative controls. Segmental QAT of cervicocerebral arteries were measured using automated image processing and differences between groups analyzed.

Results—
In negative controls, QAT showed significant age-related variability for most arterial segments. Positive controls showed significantly increased QAT of the distal extracranial vertebral arteries (VAs) and decreased QAT of the intracranial VA relative to negative controls. Cryptogenic stroke and bow hunter physiology cases were similar to positive controls showing increased QAT of the distal extracranial VA and decreased QAT of the intracranial VA relative to negative controls. Cardioembolic stroke cases were similar to negative controls showing decreased QAT of the distal extracranial VA and increased QAT of the intracranial VA relative to positive controls.

Conclusions—
Pediatric cryptogenic stroke is frequently associated with cervicocerebral arteriopathies expressing altered QAT. QAT may be a diagnostic biomarker of arteriopathy in pediatric AIS.
Eschatology, Androgynous Thinking, Encratism, and the Question of Anti-Gnosticism in 2 Clement 12 (Part One)
Authors: Kelhoffer James A. 
Published: March 2018

Abstract
This article problematizes the widespread use of an untenably broad definition of Gnosticism to support claims that 2 Clement 12 is antignostic. Several conclusions about the writing’s aims and opponents must therefore be reconsidered. It is argued that 2 Clement 12 is not polemical and does not censure any distinctively gnostic views or praxes. By shedding both the supposedly gnostic background of the dominical logion about “the two” becoming “one,” about the “outside” being like the “inside,” and about “neither male nor female” (12:2b, 6b) and an antignostic agenda for the interpretations of the logion (12:3-5), scholarship has a better chance of opening up promising avenues for interpreting this saying of Jesus and its interpretation in 2 Clement 12.
Social inclusion of the people with mental health issues: Compare international results
Authors: Santos Jussara Carvalho dos , Barros Sônia , Huxley Peter John 
Published: March 2018

Background: Social inclusion of people with mental health issues is an aim of the World Health Organisation. Many countries have adopted that objective, including Brazil and the United Kingdom and both have focused treatment in the community. The aim of this article is to compare international results using the same inclusion instrument. Methods: The samples in this study were 225 people with mental health issues in community services in São Paulo, Brazil. Their results are compared to findings from 168 people with similar mental health issues in Hong Kong, China, and from the United Kingdom – a nationally representative sample of 212 people without mental health issues. The instrument used to measure a social inclusion called Social and Communities Opportunities Profile (SCOPE) has been validated for use in the United Kingdom, China and Brazil. Results: The results are that people with mental health issues have worse social inclusion when compared to general population. Between the people with mental health issues, the sample of São Paulo has the lowest social inclusion index but, in relation to access to the Brazilian revised mental health services, that sample has a similarly high inclusion rating to the general population of the United Kingdom. Conclusion: Findings are important to understand mental health in the community context, as well as their adversities and potentialities.
Effects of remifentanil and dexmedetomidine on the mother’s awareness and neonatal Apgar scores in caesarean section under general anaesthesia
Authors: Kart Kenan , Hanci Ayse 
Published: March 2018

Objective This study aimed to compare the effects of remifentanil and dexmedetomidine on awareness during the induction of general anaesthesia. Material and Methods Ninety patients scheduled for elective caesarean section under general anaesthesia were included and randomly divided into three anaesthesia groups: 2 mg/kg propofol (control group); 2 mg/kg propofol and 1 µg/kg dexmedetomidine (dexmedetomidine group); and 2 mg/kg propofol and 1 µg/kg remifentanil (remifentanil group). All patients received routine monitoring, and Apgar scores at 1 and 5 minutes were recorded. The bispectral index and the isolated forearm technique were used to determine the depth of anaesthesia. Results Bispectral index values at skin and uterine incisions and at delivery were similar among the groups. The number of patients who responded positively to the isolated arm technique during the induction period was also similar. One-minute Apgar scores in the control group were significantly lower and 5-minute Apgar scores significantly higher than those in the other groups. Conclusion The effects of remifentanil and dexmedetomidine added to propofol on maternal awareness, neonatal Apgar scores, and bispectral index values were similar compared with propofol alone. However, it was observed that remifentanil controlled the haemodynamic responses to sympathetic stimuli in a better manner than dexmedetomidine.
Oxycodone for prevention of etomidate-induced myoclonus: a randomized double-blind controlled trial
Authors: Wang Wei , Lv Jie , Wang Qi , Yang Lei , Yu Wanyou 
Published: March 2018

Objective This study was performed compare the effectiveness of oxycodone and fentanyl in reducing the incidence and severity of etomidate-induced myoclonus. Methods In total, 162 patients with an American Society of Anesthesiologists physical status of I or II were assigned at random to three groups. Patients assigned to Group O received 0.1 mg/kg of oxycodone (n = 54), those assigned to Group F were given 1 µg/kg of fentanyl (n = 54), and those assigned to Group S were given an equal volume of saline intravenously 2 minutes prior to administration of 0.3 mg/kg of etomidate (n = 54). The incidence and severity of myoclonus was evaluated 2 minutes after etomidate administration. The patients’ vital signs, coughing, nausea, dizziness, and other related adverse reactions were also recorded. Results The incidence of myoclonus was significantly lower in Group O (0.0%) than in Group F (31.5%) and Group S (72.2%); the intensity was also lowest in Group O. All patients in each group had stable cardiovascular profiles. Conclusions Intravenous injection of 0.1 mg/kg of oxycodone 2 minutes prior to etomidate is more effective in preventing etomidate-induced myoclonus during general anesthesia than is 1 µg/kg of fentanyl.
Critical Glenoid Bone Loss in Posterior Shoulder Instability
Authors: Nacca Christopher , Gil Joseph A. , Badida Rohit , Crisco Joseph J. , Owens Brett D. 
Published: March 2018

Background: There is currently no consensus regarding the amount of posterior glenoid bone loss that is considered critical. Critical bone loss is defined as the amount of bone loss that occurs in which an isolated labral repair will not sufficiently restore stability. Purpose: The purpose is to identify the critical size of the posterior defect. Study Design: Controlled laboratory study. Methods: Eleven cadaveric shoulders were tested. With the use of a custom robot device, a 50-N compressive force was applied to the glenohumeral joint, and the peak force that was required to translate the humeral head posteriorly and the lateral displacement that occurred with translation were measured. The defect size was measured as a percentage of the glenoid width. Testing was performed in 11 conditions: (1) intact glenoid and labrum, (2) simulated reverse Bankart lesion, (3) the reverse Bankart lesion repaired, (4) a 10% defect, (5) the reverse Bankart lesion repaired, (6) a 20% defect, (7) the reverse Bankart lesion repaired, (8) a 30% defect, (9) the reverse Bankart lesion repaired, (10) a 40% defect, and (11) the reverse Bankart repaired. Results: Force and displacement decreased as the size of the osseous defect increased. The mean peak force that occurred with posterior displacement in specimens with a glenoid defect ≥20% and a reverse Bankart repair (13 ± 9 N) was significantly lower than the peak force that occurred in specimens with an isolated reverse Bankart repair (22 ± 10 N) ( P = .0451). In addition, the mean lateral displacement was significantly less in the specimens with a 20% glenoid defect and a reverse Bankart repair (0.61 ± 0.57 mm) compared with the lateral displacement that occurred in specimens with an isolated reverse Bankart repair (1.6 ± 0.78 mm) ( P = .0058). Conclusion: An osseous defect that is ≥20% of the posterior glenoid width remains unstable after isolated reverse Bankart repair. Clinical Relevance: A bony restoration procedure of the glenoid may be necessary in shoulders with a posterior glenoid defect that is ≥20% of the glenoid width.
Basel I to Basel III: Impact of Credit Risk and Interest Rate Risk of Banks in India
Authors: Rizvi Noor Ulain , Kashiramka Smita , Singh Shveta 
Published: March 2018

The study explores the theoretical background of Basel III and investigates the drivers of interest rate risk and credit risk of banks in various parlances, namely, pre and post the financial crisis, phases of implementation and ownership on a sample of 36 listed banks in India. The findings indicate that the high capital adequacy requirement (CAR) exhibits a positive relation with gross non-performing assets (GNPAs) and net interest margin (NIM). This is perhaps one of the major drawbacks of Basel implementation, which may become a cause of lower GDP in the future as explained in the findings of the literature. Originality/value: This article is perhaps the first attempt of its kind to empirically examine the bank-specific, macroeconomic variables and link it with the Basel implementation in the Indian banking system for the time period 2002–2015. This study endeavours to enhance the existing empirical research in the field and give insights into the role of various factors on GNPAs and interest rates (with regards to Indian banks).
Cytokeratin-18 fragments predict treatment response and overall survival in gastric cancer in a randomized controlled trial
Authors: Nagel Michael , Schulz Julia , Maderer Annett , Goepfert Katrin , Gehrke Nadine , Thomaidis Thomas , Thuss-Patience Peter C , Al-Batran Salah E , Hegewisch-Becker Susanna , Grimminger Peter , Galle Peter Robert , Möhler Markus , Schattenberg Jörn Markus 
Published: March 2018

Background:Gastric cancer is common malignancy and exhibits a poor prognosis. At the time of diagnosis, the majority of patients present with metastatic disease which precludes curative treatment. Non-invasive biomarkers which discriminate early from advanced stages or predict the response to treatment are urgently required. This study explored the cytokeratin-18 fragment M30 and full-length cytokeratin-18 M65 in predicting treatment response and survival in a randomized, placebo-controlled trial of advanced gastric cancer.Methods:Patients enrolled in the SUN-CASE study received sunitinib or placebo as an adjunct to standard therapy with leucovorin (Ca-folinate), 5-fluorouracil, and irinotecan in second or third line. Treatment response rates, progression-free survival and overall survival were assessed during a follow-up period of 12 months. Cytokeratin-18 fragments were analyzed in 52 patients at baseline and day 14 of therapy.Results:Levels of M30 correlated with the presence of metastasis and lymph node involvement and decreased significantly during chemotherapy. Importantly, baseline levels of M30 were significantly higher in patients who failed therapy. In addition, patients who did not respond to treatment were also identifiable at day 14 based on elevated M30 levels. By stepwise regression analysis, M30 at day 14 was identified as independent predictor of treatment response. Likewise, serum levels of full-length cytokeratin-18 M65 at baseline also correlated with treatment failure and progression-free survival. The addition of sunitinib did not exert any effects on serum levels of M30 or M65.Conclusion:The cytokeratin-18 fragment M30 at day 14 identifies patients that fail to second- or third-line therapy for advanced gastric cancer. Validation of this non-invasive biomarker in gastric cancer is warranted.
Incidence of Speech-Correcting Surgery in Children With Isolated Cleft Palate
Authors: Gustafsson Charlotta , Heliövaara Arja , Leikola Junnu , Rautio Jorma 
Published: March 2018

Objective: Speech-correcting surgeries (pharyngoplasty) are performed to correct velopharyngeal insufficiency (VPI). This study aimed to analyze the need for speech-correcting surgery in children with isolated cleft palate (ICP) and to determine differences among cleft extent, gender, and primary technique used. In addition, we assessed the timing and number of secondary procedures performed and the incidence of operated fistulas. Design: Retrospective medical chart review study from hospital archives and electronic records. Participants: These comprised the 423 consecutive nonsyndromic children (157 males and 266 females) with ICP treated at the Cleft Palate and Craniofacial Center of Helsinki University Hospital during 1990 to 2016. Results: The total incidence of VPI surgery was 33.3% and the fistula repair rate, 7.8%. Children with cleft of both the hard and soft palate (n = 300) had a VPI secondary surgery rate of 37.3% (fistula repair rate 10.7%), whereas children with only cleft of the soft palate (n = 123) had a corresponding rate of 23.6% (fistula repair rate 0.8%). Gender and primary palatoplasty technique were not considered significant factors in need for VPI surgery. The majority of VPI surgeries were performed before school age. One fifth of patients receiving speech-correcting surgery had more than one subsequent procedure. Conclusion: The need for speech-correcting surgery and fistula repair was related to the severity of the cleft. Although the majority of the corrective surgeries were done before the age of 7 years, a considerable number were performed at a later stage, necessitating long-term observation.
Determinants of Health-Related and Oral Health–Related Quality of Life in Adults With Orofacial Clefts
Authors: Corrêa de Queiroz Herkrath Ana Paula , Herkrath Fernando José , Bessa Rebelo Maria Augusta , Vettore Mario Vianna 
Published: March 2018

Objectives: To investigate the structural and intermediary determinants of health-related quality of life (HRQoL) and oral health–related quality of life (OHRQoL) among adults with cleft lip and/or palate (CL/P). Design and Participants: A cross-sectional study was conducted with patients enrolled at the referral center for craniofacial anomalies in Manaus, Brazil. Adults aged 18 years or more with nonsyndromic CL/P were selected. Main Outcome Measures: Both HRQoL and OHRQoL were assessed using the 36-item Short-Form Health Survey and the Oral Impacts on Daily Performance, respectively. Individual interviews and oral examinations were conducted to collect data on socioeconomic and demographic characteristics, social ties, health-related behaviors, compliance of CL/P protocol, chronic diseases, type of CL/P, oral clinical measures, and CL/P-related measures. Poisson regression was used to test the association of independent variables with HRQoL and OHRQoL outcomes. Results: The mean age of the 96 participants was 29.4 ± 9.1 years. Low family income, female sex, low social support, type of CL/P, and dental caries were associated with poor HRQoL and poor OHRQoL ( P < .05). Poor HRQoL was also associated with chronic diseases ( P < .05). Adults with low education, low social network, and smokers were more likely to have worse OHRQoL ( P < .05). Conclusions: Structural and intermediary determinants were related to HRQoL and OHRQoL in adults with CL/P, suggesting the need for interdisciplinary approaches to improve the management of CL/P and intersectoral actions to reduce the impact of social inequalities.
Shaping Audiences Online: Principles of Audience Development for Cultural Institutions
Authors: Gillard Patricia 
Published: March 2018

Audience development is an applied form of audience analysis which reveals to an organisation the nature of its different audiences. With a clearer definition of how audiences interpret and use its programs and services, an organisation can develop those programs and communication strategies which are likely to engage audiences more effectively. This usually means an expansion of the audience base, and a clearer positioning of the organisation's work. Cultural institutions are increasingly using Websites to communicate with external audiences and incorporating new media into exhibitions onsite. The mix of communications with both onsite and online audiences challenges earlier ways of thinking about who are the audiences for cultural institutions and how they should be measured. Fundamental conceptual questions need to be answered, and an audience development strategy adopted which builds visitation across virtual and material sites.
Battling the Commercialisation of the Swedish Mediasphere
Authors: Svensson Kent , Green Lelia 
Published: March 2018

The regulation of national broadcasting is a forum for the official expression of a country's media priorities. Sweden has consistently attempted to prevent foreign broadcasters from establishing themselves in the Swedish mediasphere. Subsequently, wherever a non-Swedish broadcaster has demonstrated market demand for a media product not available in Sweden, the government has attempted to create a Swedish equivalent to meet public demand and prevent the loss of audience share to non-Swedish broadcasters. This dynamic is especially clear in terms of the introduction of commercial broadcasting. Sweden was the last country in Western Europe to license a commercial television station, in 1992. This case study addresses the accommodation of the historically socialist government to the demands for commercial broadcasting, and the policy debates which informed these deliberations. It is argued that one reason for the Swedish government resisting commercial television was an opposition to the country's further integration within global capitalism, regardless of the fact that Swedish technology has helped the expansion of transnational broadcasting systems.
Conceptualising the Virtual and the Posthuman
Authors: Pappas Vanessa 
Published: March 2018

This article aims to explore the relations between technology and the subject. With new media intensifying the provisionality of discursive structures and in turn embodied experiences, questions pertaining to virtuality have become vital, particularly since Western society's increasing reliance on technologies now permeates our everyday practices. While many theorists often resort to a reification of the subject when conceptualising the posthuman condition, this analysis will recover the notion of embodiment in order to avoid such technological determinism. Tracing this complexity in contemporary texts can be achieved through various means. Here, the focus will remain on how narrative frameworks can create new possibilities for understanding and interpreting shifting subjectivities in the digital age. To explore this, I shall provide an analysis of a contemporary film, Being John Malkovich, which has been chosen due to its unexpected success at the box office, indicating how finely attuned the film is to contemporary concerns.