bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aligning teacher competence frameworks to 21st century challenges: The case for the European Digital Competence Framework for Educators (Digcompedu)
Authors: Caena Francesca , Redecker Christine 
Published: August 2019

AbstractTeachers need to update their competence profiles for 21st century challenges. Teaching strategies need to change and so do the competences teachers need to develop so as to empower 21st‐century learners. The European Framework for the Digital Competence of Educators (DigCompEdu) represents a paradigmatic example of this endeavour, taking stock of these needs. Defining the requirements of education professionals by teacher competence frameworks can serve multiple purposes at different levels in education systems. At the micro level, it can support and guide teachers' practice and continuous professional development. At the meso level of local education governance, it can support the development of school institutions as learning organisations, providing common ground for dialogue, collaboration and reflection in professional communities of practice. At the macro level of quality assurance, it can provide reference standards for initial teacher education, and for education professionals' quality along the career continuum. The European Framework for the Digital Competence of Educators was designed to align with institutional and contextual requirements in different countries, whilst remaining open to adaptation and updating. It links teachers' and students' digital competence development, and can be linked to institutional capacity building. At the same time, the framework is generic enough to apply to different educational settings and to allow for adaptation as technological possibilities and constraints evolve.
Extracorporeal shockwave therapy raises mechanical nociceptive threshold in horses with thoracolumbar pain
Authors: Trager L. R. , Funk R. A. , Clapp K. S. , Dahlgren L. A. , Werre S. R. , Hodgson D. R. , Pleasant R. S. 
Published: August 2019

SummaryBackgroundAlthough extracorporeal shockwave therapy (ESWT) is a common treatment for horses with back pain, effects on mechanical nociceptive threshold (MNT) and multifidus muscle cross sectional area (CSA) in the spine are unknown.ObjectivesTo evaluate effects of ESWT on spinal MNT and multifidus muscle CSA in horses with thoracolumbar pain.Study designNon‐randomised trial.MethodsThoracolumbar spines of 12 horses with thoracolumbar pain were radiographed to document existing pathology. Each horse received three ESWT treatments, 2 weeks apart (days 0, 14, 28). Palpation scores were documented (days 0, 45 and 65). Ultrasonographic CSA of left and right multifidus muscles was recorded at T12, T14, T16, T18, L3 and L5 (days 0, 45 and 65). MNT was measured at the same spinal sites every 7 days (day 0–56).ResultsMechanical nociceptive threshold in 10/12 horses (83%) was greater at each time point compared with day 0 (P < 0.05). Mechanical nociceptive threshold increased at all time points at six sites in 2/12 (16%), at five sites in 3/12 (25%), at four sites in 4/12 (33%) and at one site in 1/12 (8%; P < 0.05). Mechanical nociceptive threshold average per cent increase from day 0 to 56 was 64% for the thoracic region (T12–T18) and 29% for the lumbar region (L3–L5). There was no statistical difference in MNT from day 35 to 56 (P = 0.25). A bimodal analgesic trend was observed following ESWT. Degree of radiographic change was not associated with response to treatment. No significant change in multifidus muscle CSA was observed.Main limitationsSmall study size and lack of control group.ConclusionsThree treatments of ESWT 2 weeks apart raised MNT over a 56‐day period in horses with back pain, but did not influence change in CSA of the multifidus muscle. While ESWT appears justifiable for analgesia, physiotherapeutic techniques may be necessary in conjunction for concurrent muscle rehabilitation.
The impact of peer corrective feedback on vocabulary development
Authors: Sippel Lieselotte 
Published: August 2019

AbstractThis study explored whether form‐focused instruction (FFI) and peer corrective feedback (CF) facilitated vocabulary development during peer interaction (PI). Third‐semester learners of German were assigned to a PI group (peer interaction only), PI FFI group (peer interaction and form‐focused instruction), or PI FFI CF group (peer interaction, form‐focused instruction, and peer corrective feedback). Participants in all groups engaged in peer interaction activities, but only the PI FFI group and the PI FFI CF group received form‐focused vocabulary instruction on German nouns, along with their grammatical genders and plural forms. Only the PI FFI CF group was taught to provide feedback to peers during peer interaction. Results from a pretest and two posttests revealed that both experimental groups outperformed the control group on measures of productive and receptive vocabulary, grammatical genders, and noun plurals. In addition, the PI FFI CF group outperformed the PI FFI group on measures of productive and receptive vocabulary. These results highlight the importance of metacognitive instruction for vocabulary development during peer interaction.
Global warming promotes biological invasion of a honey bee pest
Authors: Cornelissen Bram , Neumann Peter , Schweiger Oliver 
Published: August 2019

AbstractClimate change and biological invasions are two major global environmental challenges. Both may interact, e.g. via altered impact and distribution of invasive alien species. Even though invasive species play a key role for compromising the health of honey bees, the impact of climate change on the severity of such species is still unknown. The small hive beetle (SHB, Aethina tumida, Murray) is a parasite of honey bee colonies. It is endemic to sub‐Saharan Africa and has established populations on all continents except Antarctica. Since SHBs pupate in soil, pupation performance is governed foremost by two abiotic factors, soil temperature and moisture, which will be affected by climate change. Here, we investigated SHB invasion risk globally under current and future climate scenarios. We modelled survival and development time during pupation (=pupal performance) in response to soil temperature and soil moisture using published and novel experimental data. Presence data on SHB distribution were used for model validation. We then linked the model with global soil data in order to classify areas (resolution: 10 arcmin; i.e. 18.6 km at the equator) as unsuitable, marginal and suitable for SHB pupation performance. Under the current climate, the results show that many areas globally yet uninvaded are actually suitable, suggesting considerable SHB invasion risk. Future scenarios of global warming project a vehement increase in climatic suitability for SHB and corresponding potential for invasion, especially in the temperate regions of the Northern hemisphere, thereby creating demand for enhanced and adapted mitigation and management. Our analysis shows, for the first time, effects of global warming on a honey bee pest and will help areas at risk to prepare adequately. In conclusion, this is a clear case for global warming promoting biological invasion of a pest species with severe potential to harm important pollinator species globally.
The role of CCR1 and therapeutic effects of anti‐CCL3 antibody in herpes simplex virus‐induced Behçet's disease mouse model
Authors: Sayeed Hasan M. , Lee Eun‐So , Byun Hae‐Ok , Sohn Seonghyang 
Published: August 2019

SummaryBehçet's disease (BD) is a chronic systemic inflammatory disease with unclear etiopathogenesis. Although gene variants of CC chemokine receptor type 1 (CCR1) have been reported, the protein expression of CCR1 in patients with BD remains unclear. The objective of this study was to analyze the frequencies of CCR1+ cells in a herpes simplex virus‐induced mouse model of BD. The frequencies of CCR1+ cells on the surface and in the cytoplasm of peripheral blood mononuclear cells and lymph nodes were analyzed by flow cytometry. The CCR1+ cells were significantly down‐regulated in BD mice compared with the normal control and symptom‐free control mice. Colchicine and pentoxifylline treatment improved the symptoms of BD and increased the frequencies of CCR1+ cells in BD mice. Treatment with chemokine CC motif ligand 3 (CCL3), a ligand of CCR1, caused BD symptoms to deteriorate in 10 of 16 BD mice (62·5%) via down‐regulation of CCR1+ cells. Anti‐CCL3 antibody treatment ameliorated BD symptoms in 10 of 20 mice (50%) and significantly decreased the disease severity score compared with CCL3‐treated BD mice (P = 0·01) via up‐regulation of CCR1+ cell frequencies. In patients with BD, plasma levels of CCL3 in an active state were significantly higher than in healthy control individuals (P = 0·02). These results show that the up‐regulation of CCR1+ cells was related to the control of systemic inflammation of BD in mouse models.
Barriers to quality of work life among Bangladeshi nurses: a qualitative study
Authors: Akter N. , Akter M.K. , Turale S. 
Published: August 2019

AimTo explore and provide understanding of the barriers to quality of work life among registered nurses in Bangladesh.BackgroundGlobally, there is growing interest in the working environments of nurses, especially at a time of nursing shortages and with the focus on safety and care quality in health systems. In a low socio‐economic country like Bangladesh, nurses struggle in a grossly underfunded healthcare system to deliver care to the people but no studies have been conducted on their quality of work life.MethodsThis qualitative descriptive study was conducted at three Bangladeshi tertiary hospitals in May 2015–January 2016. Three focus group discussions were held with 30 registered nurses exploring their perceived barriers to quality of work life. Data were analysed with content analysis.FindingsSeven barriers to their work‐life arose: heavy workloads; lack of government accommodation and transportation; poor health status; lack of support from nursing supervisors; lack of promotion opportunities; incomplete hospital policies and procedures; and lack of night shift and risk allowances.DiscussionParticipants described many issues and barriers impacting on their work‐life. They perceived little reward for their hard work, felt that their health suffered from their working conditions and described a low QWL.Conclusion and policy implicationsFindings provide information for nursing and health policymakers and leaders to reduce barriers to improve work‐life quality among nurses that can contribute better to quality of nursing care, and nursing retention and satisfaction. Work policies and practices, and funding and other resources need to be scrutinized to ensure better working conditions for Bangladeshi nurses.LimitationsInterviews were conducted with nurses only in tertiary hospitals in the Bangladeshi capital, and understanding of barriers to work‐life quality of nurses in other health settings and regions needs to be explored.
Adaptation and validation of the Stanford Presenteeism Scale‐6 in healthcare professionals
Authors: Baldonedo‐Mosteiro M. , Sánchez‐Zaballos M. , Rodríguez‐Díaz F.J. , Herrero J. , Mosteiro‐Díaz M.P. 
Published: August 2019

AimTo develop and psychometrically test the Stanford Presenteeism Scale‐6 to assess presenteeism in the Spanish healthcare population.BackgroundPresenteeism, referring to going to work despite being ill, has been associated with job stress, productivity losses, reduced patient safety and increased health problems among the professionals who suffer from it.IntroductionThe highest prevalence of presenteeism in the healthcare sector is among nurses. Their decision to attend work while ill has been related to role overload, lack of supervisor support, mental health and physical conditions.MethodsA cross‐sectional and validation study was conducted between September 2015 and June 2016 in a hospital in Asturias, Spain. Four hundred and ninety‐five healthcare professionals voluntarily agreed to participate (281 nurses, 122 physicians and 92 nursing assistants).ResultsPresenteeism prevalence was high; the majority of it being in the nursing category. Bartlett's test and the Kaiser–Meyer–Olkin test indicated that the data meet the conditions for factorial analysis, evidencing a small variability in the median of each sample item and a significant standard deviation. Adjustment rates obtained in the exploratory factor analysis showed adequacy, and reliability rates also showed adequacy for both factors. It was verified by a confirmatory analysis that the factors of presenteeism are positively associated with burnout.ConclusionThe Stanford Presenteeism Scale‐6 showed good psychometric properties to study presenteeism in the Spanish healthcare sector.Implications for Nursing and Health PolicyNursing leaders must develop measurements to assess and control psychosocial risks in order to improve the physical and mental health of professionals and reduce patient safety risks.
Twenty‐five years of the Information Systems Journal: A bibliometric and ontological overview
Authors: La Paz Ariel , Merigó José M. , Powell Philip , Ramaprasad Arkalgud , Syn Thant 
Published: August 2019

AbstractThe Information Systems Journal (ISJ) published its first issue in 1991, and in 2015, the journal celebrated its 25th anniversary. This study presents an overview of the leading research trends in the papers that the journal has published during its first quarter of a century via a bibliometric and ontological analysis. From a bibliometric perspective, the analysis considers the publication and citation structure of the journal. The study then develops a graphical analysis of the bibliographic material by using visualization of similarities software that employs bibliographic coupling and cocitation analysis. The work produces an ontological framework of impact and analyses the journal papers to assess qualitatively ISJ's impact. The results indicate that the journal has grown significantly over time and is now recognized as one of the leading journals in information systems. Yet challenges remain if the journal is to meet its aims in impacting and setting the agenda for the development of the Information Systems field.
A combination therapy of nanoethosomal piroxicam formulation along with iontophoresis as an anti‐inflammatory transdermal delivery system for wound healing
Authors: Kazemi Mostafa , Mombeiny Reza , Tavakol Shima , Keyhanvar Peyman , Mousavizadeh Kazem 
Published: August 2019

AbstractInflammation accounts as one of the major phases in wound healing, while prolonged and chronic inflammation may lead to adverse pathological conditions. Therefore, transdermal delivery of nonsteroidal anti‐inflammatory (NSAIDs) such as encapsulated piroxicam into a nanocarrier seems to be promising. For the first time, a nanoethosomal piroxicam of <200 nm was prepared and combined with iontophoresis. Results showed that there was a critical point at the concentration of 5 mg lecithin with the smallest particle size. Besides, lecithin concentration had direct and inverse linear relationships with turbidity and pH of nanocarriers, respectively. Moreover, as there was no linear relationship between the lecithin concentration and particle size, the effect of lecithin concentration was dominant on turbidity compared with particle size. It seems that a pH higher than 5.5 disturbed the linear relationship of pH and entrapment efficacy percentage (EE%) while at the pH range of 4 to 5.5, the relationship was linear and EE% gradually decreased with increasing pH. These data showed that an optimised nanocarrier with special physicochemical properties is dominant to the just particle size. Besides, ex vivo permeation studies in rat skin showed that there was no significant difference between the permeation of free drug and ethosomal ones. However, iontophoresis significantly enhanced ethosomal piroxicam permeation compared with the free drug. Overall, these data emphasise the superiority of iontophoresis for the transdermal delivery of nanoethosomal medications while nanoethosomal delivery without iontophoresis did not show significant transdermal potential. To sum up, transdermal nanoethosomal piroxicam along with iontophoresis seems to be promising in wound healing.
Fluoroscopy reduction during device implantation by using three‐dimensional navigation. A single‐center experience
Authors: Larsen Timothy R. , Saini Aditya , Moore Jessica , Huizar Jose F , Tan Alex Y , Ellenbogen Kenneth A. , Kaszala Karoly 
Published: August 2019

AbstractBackground and objectivesThe use of nonfluoroscopic three‐dimensional electroanatomic mapping (3DM) systems reduces radiation exposure during ablation procedures. In this study, we sought to determine the value of 3DM during routine device implant procedures.MethodsSeventy nonselected patients underwent implantation of a single chamber, dual chamber, or biventricular device guided by Ensite (Abbott Laboratories) to limit fluoroscopy use and compared with 70 consecutive patients, who underwent matching procedures with standard fluoroscopy use (FL) in the period immediately preceding the use of 3DM. The venous anatomy, right atrium, and ventricle and coronary sinus were mapped with 0.035 inch J‐wire, quadripolar catheter, and/or angioplasty wire. The leads were advanced under real‐time visualization in Ensite.Results3DM reduced both fluoroscopy time and dose. Median fluoroscopy time for FL vs 3DM was 5.5 minutes (interquartile range [IQR]: 3.8‐8.1) vs 0.9 minutes (IQR: 0.6‐1.9) (P < .001) for single chamber devices, 6.3 minutes (IQR: 5.1‐7.9) vs 3.3 minutes (IQR: 1.9‐4) (P < .001) for dual‐chamber devices, and 28.6 minutes (IQR: 19.6‐36.2) to 14.7 minutes (IQR: 10.4‐22.3) (P = .009) for biventricular devices, respectively. The median air kerma for FL vs 3DM was 15.4 mGy (IQR: 8.1‐30.2) vs 4 mGy (IQR: 1.8‐8) (P < .001) for single chamber devices, 16 mGy (IQR: 12‐18.5) to 9.4 mGy (IQR: 7.5‐11.3) (P = .001) for dual‐chamber devices, and 324 mGy (IQR: 143‐668.7) to 115 mGy (IQR:77‐204) (P = .014) for biventricular devices, respectively. There were no procedural complications. At 3‐month follow‐up, there was no difference in voltage threshold measurements between the groups.ConclusionThe use of 3DM leads to significantly reduced fluoroscopy time and fluoroscopy dose during routine device implantation.
Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation
Authors: Choi Jong‐Il , Baek Yong Soo , Roh Seung Young , Piccini Jonathan P. , Kim Young‐Hoon 
Published: August 2019

AbstractIntroductionLittle is known about how genetic predisposition and fibrosis relate in atrial fibrillation (AF). Hence, we sought to determine whether the genetic variants and biomarkers for fibrosis enhance prediction of outcomes after catheter ablation.Methods and ResultsConsecutive patients who underwent catheter ablation of AF (paroxysmal, 158; nonparoxysmal, 137) or supraventricular tachycardia without AF (n = 70) were studied retrospectively. Plasma levels of transforming growth factor β1 (TGF‐β1), tissue inhibitor of metalloproteinase 1 (TIMP‐1), and 4q25 single‐nucleotide polymorphisms (SNPs) (rs10033464 and rs220073) were measured. Mean plasma levels of both TGF‐β1 and TIMP‐1 were higher in patients with AF than in the control (all P < .001). Plasma levels of TIMP‐1 were higher in patients with recurrence compared with those without recurrence (P = .039). Patients with variant alleles of rs10033464 showed increased recurrence after catheter ablation in patients with paroxysmal AF including after adjustment (P = .027). Patients with TIMP‐1 < 107 ng/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; P = .007), whereas there was no significant difference among those patients with persistent forms of AF. Inclusion of biomarkers and genotype improved discrimination of AF recurrence in patients with paroxysmal AF (C‐statistic .499 vs .600).ConclusionsThe combination of plasma TIMP‐1 concentrations less than 107 ng/mL and the absence of a variant allele at rs10033464 was associated with lower recurrence rates in patients with paroxysmal AF. This study suggests that 4q25 SNPs and biomarkers for fibrosis may provide additive value in risk stratification for AF recurrence after catheter ablation.
Self‐blood pressure monitoring is associated with improved awareness, adherence, and attainment of target blood pressure goals: Prospective observational study of 7751 patients
Authors: Jo Sang‐Ho , Kim Sung‐Ai , Park Kyoung‐Ha , Kim Hyun‐Sook , Han Sang‐Jin , Park Woo‐Jung 
Published: August 2019

AbstractWe investigated whether self‐blood pressure monitoring (SBPM) can improve the control rate of blood pressure (BP), adherence of antihypertensive medications, and the awareness of the importance of BP control in hypertensive patients. A total of 7751 patients who visited the outpatient clinics of private and university hospitals in Korea were given automatic electronic BP monitors and were recommended to measure their BP daily at home for 3 months. Changes in office BP, attainment of target BP, adherence to taking antihypertensive drugs, and awareness of BP were compared before and after SBPM. Patients and physicians were surveyed on their perception of BP and SBPM. Mean BP significantly decreased from 142/88 to 129/80 mm Hg (P < .001), and attainment of the target BP increased from 32% to 59% (P < .001) after SBPM. Drug non‐adherence, which was defined as patient's not taking medication days per week, decreased significantly from 0.86 days to 0.53 days (P < .001). The rate of awareness of the BP goal increased from 57% to 81% (P < .001). Patients estimated that their mean BP was 125/81 mm Hg, but their actual mean BP was 142/88 mm Hg. Awareness about the importance of SBPM increased from 90% to 98%. The rate of SBPM ≥ once per week further increased, from 34% to 96%. In conclusion, SBPM is associated with reduced BP, better BP control rate, greater drug adherence, and improved perception of BP by the patients.
Reproductive biology, multiple paternity and polyandry of the bull shark Carcharhinus leucas
Authors: Pirog Agathe , Magalon Hélène , Poirout Thomas , Jaquemet Sébastien 
Published: August 2019

AbstractTo improve understanding of bull shark Carcharhinus leucas reproductive biology, we analysed reproductive traits from 118 bull sharks caught along Reunion Island coasts (Western Indian Ocean), including 16 gravid females. Specific microsatellite loci were used to investigate the frequency of multiple paternity. Males and females reached maturity at c. 234 cm and 257 cm total length (LT), respectively, and litter sizes ranged from 5 to 14 embryos. Analysis of the 16 litters collected in various months of the year indicated that parturition occurs between October and December, with a size at birth c. 60–80 cm LT and that the gestation period is probably c. 12 months. Assuming a 1 year resting period and a period of sperm storage (4–5 months) between mating (in June–September) and fertilisation, the reproductive cycle of bull sharks at Reunion Island would be biennial. At least 56.25% of the litters investigated were polyandrous, sired by 2–5 males. Several males that each sired several litters conceived during the same or distinct mating seasons were detected, suggesting both a seasonal aggregation of sharks to mate and some male fidelity to mating site. Altogether, these findings provide valuable information for both shark risk management and conservation of the species in the Western Indian Ocean.