bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actualization of family values in the post-sacral day: Challenges for the State and Church
Authors: Fylypovych Liudmyla O. 
Published: April 2019

The article is devoted to the problems of the modern family faced with the complicated challenges of the XXI century in post-secular society.
In place of the religious world order, which regulated family relations for millenia, based on unchanging religious dogmas, a new era comes, which strongly refuses religious consecration of marriage and family, in a new way constituting the relations of secular state and church, desacralizes morality. The secular gradually covers the family and family ties, partly solving prejudiced problems of inequality of articles and generations, inequalities of social roles, and so on. Instead of changing the religious model of the family, a new type of family relationship comes in, based on the freedom of each member of the family, freeing them from slavery.
However, the secular day raises new problems, including social orphanhood, violence, single-parent families, drug addiction, etc., which need to be resolved in the post-secular society. These problems are perceived as religious (religious-based families) and non-religious (families that do not put God or gods at the heart of their relationship) families who are looking for ways out of the crisis.
The article defines the signs of this post-secular society, where both religious and secular ones exist simultaneously. In return, the separation of the secular from the religious and the suppression of the religious secular, the absolute priority of the secular over the religious comes another model. Religion on the wave of religious revival is actively included in the public sphere, is clearly represented in various social projects, including family, so that religion gradually increases its authority and influence.
In this situation, facing the complex challenges facing the family, the religious and secular worlds are forced to seek such forms of communion in order to jointly solve the problems that have arisen. Ukraine still has to overcome mutual distrust, ignorance of opportunities of each other, accumulate resources, since both the church and the state work on one subject - a citizen of the state and a believer church.
LIVING WITH DIABETES MELLITUS II: IMPACTS ON NEUROPSYCHOLOGICAL FUNCTIONING DEPRESSION AND QUALITY OF LIFE
Authors: Raj Tanya 
Published: April 2019

The aim of the present study was to examine the relationship between neuropsychological functioning, depression and quality of life among adults with diabetes mellitus-II. The study used a quantitative approach with an experimental, cross sectional matched group research design. The sample was divided into two groups; an experimental group of adults with diabetes mellitus and a control group of matched healthy individuals, with 30 participants in each group. The sample was recruited from Delhi using convenience and snowball sampling. A self designed questionnaire was administered for understanding about diabetes and its management in the experimental group. NIMHANS neuropsychological battery and WAIS- IV (Two subtests only), Beck Depression Inventory and WHOQOL questionnaire was used for examining neuropsychological functioning, depression and quality of life among adults with diabetes mellitus and matched healthy individuals. Participants among adults with diabetes mellitus group were provided a self –designed brochure on the self-management of diabetes. Descriptive statistics like frequency, percentage etc and inferential statistics like MNOVA and correlations were used for analysis of the data. Results indicated a significant relationship on total neuropsychological functioning between the two groups. Significant differences were found in some components of neuropsychological functioning, viz. executive functions, attention and working memory. Non-significant relationships were found on depression and quality of life. The experimental group was aware about diabetes and its management. Awareness and motivation for self- management provides better health outcomes. Comprehensive psychosocial and behavioural interventions by psychologists can delay complications of neuropsychological functioning of individuals with diabetes mellitus.
ORAL HEALTH RELATED QUALITY OF LIFE OF PATIENTS AFTER IMPLANT TREATMENT: A PROSPECTIVE COHORT STUDY IN A PRIVATE DENTAL PRACTICE
Authors: REHMAN MOHAMMED SIRAJ UR 
Published: April 2019

Introduction: Clinicians are currently unable to quantify the psychosocial, functional, and esthetic effects of prosthetic interventions to replace teeth. Understanding the effects of treatment to replace teeth on oral health-related quality of life (OHRQoL) is important.
Aims and Objectives: This study aimed at analysing the improvement of OHRQoL of patients who underwent dental implant treatment using the “functional”, “psychosocial” and “pain and discomfort” categories of the Geriatric Oral Health Assessment Index (GOHAI).
Materials and Methods: These patients were assessed for their OHRQoL by answering a GOHAI questionnaire before implant placement and between 3 to 9 months after treatment. Gender, age, tobacco habits and potential preliminary periodontal treatment were also determined at the beginning of the study. In our study, evaluation process of OHRQol was assessed using the GOHAI questionnaire and data were collected during interviews. GOHAI comprised 12 items. For each one a score between 1 and 5 was given.
Results: Out of 200 subjects, 125 were males and 75 females at a ratio of 1.66 to 1. The mean age was 45±2.9 years. According to the degree of oral treatment needed, the subjects were categorised as “Single Tooth” (n = 95), “Fixed Partial Denture” (n = 85; 2 to 6 teeth replaced) and “Full Prostheses” (n = 20; 10 to 14 replaced teeth). The latter category comprised “full fixed Prostheses” (n = 9) and “Implant Retained Complete Over-denture” (n = 11). The characteristics of this population did not have any statistically significant impact on GOHAIAdd scores before or after treatment. These parameters were also not associated with changes in the OHRQoL of the participants.
Conclusion: OHRQoL was found to be improved after oral treatment by implants.
Key Words: Implant, Oral health, Questionnaire Removable Partial Denture, Fixed Partial Denture.
Herramientas didácticas Web 2.0 utilizando WebQuest aplicativo en aulas virtuales.
Authors: Miranda Realpe Jorge , Patiño Hernández Luis , Arcos Ponce Doris 
Published: April 2019

La propuesta sobre “Herramientas didácticas web 2.0 utilizando WebQuest aplicativo en aulas virtuales”, pretende orientar a los docentes sobre la aplicación metodológica – didáctica de su entorno virtual de aprendizaje con los estudiantes de las diferentes carreras de la UPEC. El trabajo comprende dos partes. La primera parte se refiere al diseño del Estado del Arte (plan/anteproyecto) en el cuál se plantea un perfil que contiene: nombre del proyecto, introducción, planteamiento del problema, justificación, objetivos, sistema de hipótesis, metodología, marco teórico referencial, cronograma y bibliografía. El estado del arte corresponde a un estudio con referencias anteriores, así mismo se plantea la necesidad del uso correcto de las tics tomando como referencia el articulado según la Constitución y Ley de Educación Superior. Se analiza información básica sobre los conceptos fundamentales en el marco teórico referencial. Junto con la metodología se ha determinado la población y se ha calculado la muestra con un margen de error aceptable, convirtiéndose en una muestra probabilística. La Segunda parte se refiere al Informe de la propuesta. Contiene preliminares, cuerpo del informe y sección de referencias. El cuerpo del informe estará constituido por marco teórico, diagnóstico (según encuestas, entrevistas, observación), propuesta basada en WebQuest y determinación de Hipótesis (aceptación o rechazo). Este trabajo se ha subdivido en fases, que corresponden al levantamiento de información, organización de grupos de docentes según el nivel de conocimiento de las herramientas informáticas y diseño y aplicación de aulas virtuales. Finalmente, es importante recalcar que es un proyecto aplicativo exclusivamente para la UPEC, y puede servir de semillero-prototipo para otras instituciones educativas a nivel local, nacional e internacional, a través de la transferencia de tecnología.
SUPERVISI PENGEMBANGAN BUKU TEKS FISIKA SEKOLAH MENENGAH ATAS KELAS X BERBASIS NILAI KEISLAMAN
Authors: Suharsih Suharsih , Supraha Wido 
Published: April 2019

<p><em>Kemerosotan akhlak pada masa sekarang sangat memprihatinkan. Masalah ini tentu sangat berkaitan erat dengan konsep pendidikan yang cenderung hanya menekankan kepada aspek kognitif dan aspek psikomotor saja. Kurangnya penanaman nilai keimanan, akan berdampak pada perilaku manusia dalam berinteraksi baik dengan Allah, dengan sesama, maupun dengan alam semesta. Sehubungan dengan hal itu kami telah melakukan penelitian kualitatif di mana pemaparannya menggunakan pendekatan deskriptif. Penelitian ini adalah mengkaji nilai keimanan pada buku yang diterbitkan oleh Mediatama yang berjudul Fisika untuk SMA Kelas X Kelompok Peminatan Matematika dan Ilmu-Ilmu Alam. Kami menemukan bahwa buku Fisika untuk SMA Kelas X Kelompok Peminatan Matematika dan Ilmu-Ilmu Alam tidak mendorong peningkatan nilai keimanan kepada Allah SWT ke dalam diri siswa. Hal ini tidak sejalan dengan apa yang telah diamanatkan di dalam Undang-Undang Sistem Pendidikan Nasional No 20 Tahun 2003 tentang tujuan pendidikan yaitu bahwa Pendidikan Nasional bertujuan untuk berkembangnya potensi peserta didik agar menjadi manusia yang beriman dan bertakwa kepada Tuhan yang Maha Esa, berakhlak mulia, sehat, berilmu, cakap, kreatif, mandiri, dan menjadi warga negara yang demokratis serta bertanggung jawab. Hal ini mengindikasikan tidak adanya keseuaian antara buku teks dengan tujuan pendidikan nasional, karenanya buku tersebut perlu di Islamisasi dan dikembangkan sehingga mengandung nilai-nilai keimanan kepada Allah </em><em>?</em><em> agar sesuai dengan tujuan pendidikan nasional. </em></p><p><strong><em>Keywords </em></strong><em>: Nilai (Value), Buku Teks, dan Keimanan.</em></p>
POLA KEPEMIMPINAN KEPALA SEKOLAH DALAM MEMBANGUN AKHLAK PESERTA DIDIK
Authors: Wahyudin Ujang 
Published: April 2019

<p><em>This study aims to determine the leadership pattern of the principal in developing Islamic morality of students. This study was conducted with a case study in one of the Integrated Islamic Schools in the City of Bogor, namely SMPIT El Ma'mur which has a school principal with a leadership pattern that is applied can be used as a reference for other Islamic Integrated Junior High Schools in developing Islamic morality of students. </em><em>From the results of research conducted, the leadership pattern of the head of SMPIT El Ma'mur in Bogor City in building Islamic morals is a unique type of leader, with a combination of three types of leadership, namely: democratic, transformational and authoritarian in a low level. This study uses a qualitative descriptive approach with a case study design at SMPIT El Ma'mur. The data in this study were obtained through literature study, and field studies, observation, documentation studies, and interviews</em></p>
HUBUNGAN ANTARA KEBIASAAN BELAJAR DENGAN HASIL BELAJAR ILMU PENGETAHUAN ALAM (IPA) KELAS VIII DI SMP NEGERI I KEMANG KABUPATEN BOGOR
Authors: Setyawan Rahmad , Wibowo Sigit 
Published: April 2019

Penelitian ini bertujuan untuk mengungkap apakah: Terdapat hubungan antara Kebiasaan Belajar terhadap Hasil Belajar IPA. Penelitian ini termasuk jenis penelitian korelasional dengan variabel yang diteliti yaitu: (1) Hasil Belajar IPA (Y); dan (2) Kebiasaan Belajar (X). Sampel penelitian berjumlah 62 peserta didik yang diambil dengan menggunakan teknik sampel acak (random sampling). Pengumpulan data menggunakan instrumen tes dan non-tes. Sebelum instrumen digunakan dalam penelitian, terlebih dahulu diujicobakan pada satu kelas yang setara yang ditetapkan sebagai kelas ujicoba. Kemudian dilakukan uji validitas dan reliabilitas untuk masing-masing instrumen. Uji validitas instrumen tes menggunakan korelasi Point Biserial dan uji reliabilitas menggunakan Kuder Richardson-20 (KR-20), uji validitas instrumen non-tes menggunakan korelasi Product Moment dan uji reliabilitas menggunakan Alpha Cronbach. Hasil penelitian menunjukkan bahwa: Terdapat hubungan positif antara Kebiasaan Belajar dengan Hasil Belajar IPA, nilai korelasi (Ry2) 0,435 dapat diinterpretasikan bahwa hubungan kedua variabel penelitian ada di kategori sedang. Berdasarkan hasil penelitian tersebut, Hasil Belajar IPA dapat ditingkatkan dengan cara meningkatkan Kebiasaan Belajar peserta didik
El modelo cognitivo post-racionalista. Hacia una reconceptualización teórica y clínica
Authors: Ugarte Pérez Carla 
Published: April 2019

Reseña del libro:
Guidano, V.F., & Quiñones, A.T. (2018). El Modelo cognitivo post-racionalista. Hacia una reconceptualización teórica y clínica. Bilbao: Desclée de Brouwer, 2ª edición (Colección biblioteca de psicología). ISBN: 978-84-330-1660-7.
Evolution of HIV-1 Drug Resistance after Virological Failure of First-line Antiretroviral Therapy in Lusaka, Zambia
Authors: Hudson F Parker , Mulenga Lloyd , Westfall Andrew O , Warrier Ranjit , Mweemba Aggrey , Saag Michael S , Stringer Jeffrey SA , Eron Joseph J , Chi Benjamin H 
Published: April 2019

Background HIV viral load (VL) and resistance testing are limited in sub-Saharan Africa, so individuals may have prolonged time on failing first-line antiretroviral therapy (ART). Our objective was to describe the evolution of drug resistance mutations among adults failing first-line ART in Zambia. Methods We analysed data from a trial of VL monitoring in Lusaka, Zambia. From 2006 to 2011, 12 randomized sites provided either routine VL monitoring (intervention) or discretionary (control) after ART initiation. Samples were collected prospectively following the same schedule in each arm but analysed retrospectively in the control group. For those with virological failure (VF; >400 copies/ml), HIV genotyping was performed retrospectively on baseline (BL) and on all subsequent specimens until censored due to study completion, withdrawal or death. Results Of 1,973 enrollees, 165 (8.4%) developed VF. 464 genotype results were available including 132 (80%) at BL, 116 (70%) at VF and 125 (76%) had at least one result between VF and censoring. Major nucleoside reverse transcriptase inhibitor (NRTI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) mutations increased from 26% (BL) to 82% (VF) to 89% at last genotype (LG). M184 mutations increased from 2% to 59% to 71%; K65R from 2% to 11% to 13%; 2 or more thymidine analogue mutations from 1% to 3% to 12%. Among those on a failing tenofovir disoproxil fumarate (TDF)-based regimen, TDF resistance increased from 42% to 58%. Conclusions We found substantial resistance to NRTIs and NNRTIs at VF with incremental increases after VF while still on a failing first-line ART; this resistance may compromise attainment of the UNAIDS 90-90-90 goals.
Oviposition observation of Tropidodryas serra (Serpentes: Dipsadidae)
Authors: Muscat Edelcio , Rotenberg Elsie , Machado Iberê Farina 
Published: April 2019

Tropidodryas serra is an endemic snake from the Brazilian Atlantic Forest and despite its wide distribution, little is known about its ecology. Tropidodryas serra is an oviparous snake, but there are few available data on its reproductive cycle. In this paper, we present the first report of oviposition of T. serra in captivity with successfully hatching. A pregnant female was captured in the area of Non-Governmental Organization (NGO) Dacnis Project, Ubatuba-SP, southeastern Brazil, and held captive. The spawning of 7 eggs and the development of offspring were observed. The eggs (measuring 4x1.35 cm in average) hatched in 90 days, with 6 healthy neonates and 1 stillborn. Based on a unique successful hatching of T. serra eggs in captivity, the present study confirmed with naturalistic data reproductive characteristics of the species, such as egg laying in December and low number of atresic eggs, corroborating that the species should present few reproductive events and concentrated throughout the rainy season.
ST2/MyD88 Deficiency Protects Mice against Acute Graft-versus-Host Disease and Spares Regulatory T Cells
Authors: Griesenauer Brad , Jiang Hua , Yang Jinfeng , Zhang Jilu , Ramadan Abdulraouf M. , Egbosiuba Jane , Campa Khaled , Paczesny Sophie 
Published: April 2019

Abstract
Acute graft-versus-host disease (aGVHD) hinders the efficacy of allogeneic hematopoietic cell transplantation (HCT). Plasma levels of soluble membrane-bound ST2 (ST2) are elevated in human and murine aGVHD and correlated to type 1 T cells response. ST2 signals through the adapter protein MyD88. The role of MyD88 in T cells during aGVHD has yet to be elucidated. We found that knocking out MyD88 in the donor T cells protected against aGVHD independent of IL-1R and TLR4 signaling in two murine HCT models. This protection was entirely driven by MyD88−/− CD4 T cells. Transplanting donor MyD88−/− conventional T cells (Tcons) with wild-type (WT) or MyD88−/− regulatory T cells (Tregs) lowered aGVHD severity and mortality. Transcriptome analysis of sorted MyD88−/− CD4 T cells from the intestine 10 d post-HCT showed lower levels of Il1rl1 (gene of ST2), Ifng, Csf2, Stat5, Batf, and Jak2. Transplanting donor ST2−/− Tcons with WT or ST2−/− Tregs showed a similar phenotype with what we observed when using donor MyD88−/− Tcons. Decreased ST2 was confirmed at the protein level with less secretion of soluble ST2 and more expression of ST2 compared with WT T cells. Our data suggest that Treg suppression from lack of MyD88 signaling in donor Tcons during alloreactivity uses the ST2 but not the IL-1R or TLR4 pathways, and ST2 represents a potential aGVHD therapeutic target sparing Tregs.
Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity
Authors: Cheng Liqing , Deng Nan , Yang Naixue , Zhao Xueqiang , Lin Xin 
Published: April 2019

Abstract
The paracaspase Malt1 is a key molecule in mediating Ag receptor–induced NF-κB activation in lymphocytes, but the role of Malt1 in the function of regulatory T (Treg) cells is still unclear. In this article, we reported that specific deletion of Malt1 in Treg cells would lead to Scurfy-like lethal autoimmune disease, which was caused by Treg cell dysfunction but not number loss. Interestingly, Foxp3CreMalt1fl/C472A mice, in which Malt1 protease was specifically inactivated in Treg cells, also displayed spontaneous inflammatory disorders, with severe hair loss and skin hyperplasia. Consistently, Foxp3CreMalt1fl/C472A mice showed enhanced antitumor response because of their decreased function and infiltration of Treg cells, as well as reduced CD8+ T cell exhaustion. Gene expression profiling analysis revealed dysregulated expression pattern of Treg effector genes upon Malt1 deletion or its protease inactivation. Together, our data unraveled a critical role of Malt1, especially its protease activity, in maintaining homeostasis and function of Treg cells.
O Realismo em Lukács - sua visão e concepção de arte
Authors: Sousa Douglas Rodrigues de 
Published: April 2019

György Lukács concebe a arte como uma práxis social capaz de arrancar o homem da sua forma primitiva e alçá-lo à condição de sujeito consciente, elevado. Para isso, o filósofo húngaro defende que a arte realista, do realismo como tomada de posição/atitude do artista, é um dos principais fatores para o alcance da grande obra de arte. À luz da teoria de Lukács, sobre o Realismo na literatura, empreendemos neste trabalho uma discussão teórica acerca da “arte autêntica” conforme o pensamento do crítico. Com o intuito de ilustrar as ideias do autor sobre esse processo na criação artística, realizamos uma breve leitura do conto A obra-prima ignorada, de Honoré de Balzac.
Encontrabilidade da Informação em Repositórios de Dados: uma análise do DataONE
Authors: Sanchez Fernanda Alves , Vechiato Fernando Luiz , Vidotti Silvana Aparecida Borsetti Gregorio 
Published: April 2019

Introdução: A importância da disseminação de dados de pesquisa vem sendo cada vez mais debatida pela comunidade científica, principalmente para maximizar o uso e reuso dos dados provenientes de pesquisas científicas. Os Repositórios de Dados visam o armazenamento, a organização, a disseminação, a preservação e o encontro de dados, que potencializam a comunicação e a colaboração científica. Os estudos inclusos no cenário da Ciência da Informação, como a Encontrabilidade da Informação, trazem contribuições para o projeto e implementação de ambientes informacionais digitais como os repositórios. Objetivos: A partir dessa premissa, objetivou-se analisar o repositório de dados DataONE sob o olhar da Encontrabilidade a Informação. Metodologia: Utilizou-se a técnica de observação com apoio de instrumento de avaliação - checklist, que permite a análise de ambientes informacionais a partir dos atributos de Encontrabilidade. Resultados: Como pontos positivos destaca-se o atributo de Metadados com padrão específico para a comunidade de ciência da Terra, a Ecological Metadata Language (EML), desenvolvido pelo software Morpho e o atributo de Responsividade. Como ponto negativo, nota-se a ausência de recursos de Acessibilidade. Conclusão: Conclui-se que, de modo geral, é um ambiente adequado para pesquisa e que o mesmo utiliza atributos de encontrabilidade que potencializam o encontro da informação.
Comparison of long-term kidney functions after radical nephrectomy and simple nephrectomy
Authors: Olcucuoglu Erkan , Tonyali Senol , Tastemur Sedat , Kasap Yusuf , Sirin Mehmet Emin , Gazel Eymen , Olcucuoglu Esin , Odabas Oner , Ates Can , Olcucu Mahmut Taha 
Published: April 2019

Objective
To determine if there is a difference in proceeding to CKD between patients who had undergone radical nephrectomy (RN) and simple nephrectomy (SN) for different indications by comparing the short- and long-term renal function.

Materials and Methods
We retrospectively analyzed the records of all patients who underwent nephrectomy (either for malign or benign indications) in our clinic between January 2007 and September 2017. The patients were divided into 2 groups according the type of surgery: 1) Radical nephrectomy Group, 2) Simple Nephrectomy Group. Renal function was evaluated with Glomerular Filtration Rate (GFR) calculated using the MDRD formula.

Results
A total of 276 patients were included in the study. There were 202 patients in RN Group and 74 patients in SN Group. The mean age of the patients in RN Group and SN Group were age 59,2 ± 11,5 and 49,9 ± 15,1 years, respectively (p = 0.001). GFR levels of patients in RN Group versus SN Group were as follows: Preoperative period: 84.9 vs. 81 mL/min/1.73 m2; postoperative 1st day: 60.5 vs. 84.4 mL/min/1.73 m2, postoperative 1st month 58.9 vs. 76 mL/min/1.73 m2, postoperative 1st year: 59.5 vs. 74.1 mL/min/1.73 m2; at last control 60.3 and 76.1 mL/min/1.73 m2. While preoperative GFR was found to be similar in two groups (p = 0.26), postoperative GFR values were found to be significantly lower in Group RN (p < 0.001). In comparison of the decrease in GFR in two groups at last follow-up, significantly higher decrease was observed in RN Group, 29% vs. 6%, (p < 0.05).

Conclusion
The decrease in GFR exists more common and intensive after RN compared to SN. In long-term, compensation mechanisms that develop after sudden nephron loss like radical nephrectomy deteriorates kidney function more than gradual nephron loss as in benign etiologies which indicates simple nephrectomy.