bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creating a common world through action: what participation in community activities means to older people
Authors: Endo Chikako 
Published: December 2018

AbstractAs a response to demographic ageing, various governments have been promoting social policies that promote older people's participation in productive activities, including those outside the formal labour market. Nevertheless, older people's behaviours do not simply reflect government policies and intentions. This paper explores how older people themselves interpret their social roles within a policy context that seeks to position them as providers of welfare through their participation in community activities. For this purpose, this paper draws on a qualitative case study of older people in Japan engaging in health promotion and mutual aid among local residents. By employing Hannah Arendt's distinction between the human activities of labour, work and action as a conceptual framework, it finds that although the purported purpose of community activities was to substitute decreasing pensions and family care or to create a better community, participants in this study valued their activities as a process of creating new relations and new realities through action. The paper argues that while labour has occupied a predominant position in the post-war welfare paradigm, community activities by an expanding population of older people may offer opportunities for action, which were not always available through paid work or care-giving in the household.
ON DETERMINISTIC FINITE STATE MACHINES IN RANDOM ENVIRONMENTS
Authors: Ratsaby Joel 
Published: December 2018

AbstractThe general problem under investigation is to understand how the complexity of a system which has been adapted to its random environment affects the level of randomness of its output (which is a function of its random input). In this paper, we consider a specific instance of this problem in which a deterministic finite-state decision system operates in a random environment that is modeled by a binary Markov chain. The system interacts with it by trying to match states of inactivity (represented by 0). Matching means that the system selects the (t + 1)th bit from the Markov chain whenever it predicts at time t that the environment will take a 0 value. The actual value at time t + 1 may be 0 or 1 thus the selected sequence of bits (which forms the system's output) may have both binary values. To try to predict well, the system's decision function is inferred based on a sample of the random environment.We are interested in assessing how non-random the output sequence may be. To do that, we apply the adapted system on a second random sample of the environment and derive an upper bound on the deviation between the average number of 1 bit in the output sequence and the probability of a 1. The bound shows that the complexity of the system has a direct effect on this deviation and hence on how non-random the output sequence may be. The bound takes the form of $O(\sqrt {(2^k/n} ))$ where 2k is the complexity of the system and n is the length of the second sample.
Does the meiotic spindle really predicts embryo implantation and live birth rates? An update
Authors: García-Oro Sabela , Valverde Diana 
Published: December 2018

SummaryThe aim of this study was to determine the capacity of the meiotic spindle (MS) to predict embryo implantation and live birth rates. For this purpose, we performed a broad systematic literature search. Of all publications retrieved, only those in which the implantation rates were related to some characteristics of the MS were evaluated. Despite the different methodology used in all the chosen studies, presence of the MS in oocytes was found to be positively associated with embryo implantation. Moreover, high retardance values, as well as strict criteria of normality in the MS structure, are significantly related to higher embryo implantation numbers and live birth rates.
A New and Unexpected Spatial Relationship Between Interaction Volume and Diffraction Pattern in Electron Microscopy in Transmission
Authors: Brodu Etienne , Bouzy Emmanuel 
Published: December 2018

AbstractThe finding of this study is that the interaction volume in electron microscopy in transmission is well ordered laterally, with a remarkable and unexpected consequence being that lateral subsections of the interaction volume produce subsections of the Kikuchi diffraction pattern. It makes the microstructure of samples directly visible in Kikuchi patterns. This is first illustrated with polycrystalline Ti–10Al–25Nb with an on-axis transmission Kikuchi diffraction set-up in a scanning electron microscope. It is then shown via a Monte Carlo simulation and a large-angle convergent-beam electron diffraction experiment that this phenomenon finds its origin in the nature of the differential elastic and quasi-elastic cross sections. This phenomenon is then quantified by a careful image analysis of Kikuchi patterns recorded across a vertical interface in a silicon sample specifically designed and fabricated. A Monte Carlo simulation reproducing all the geometric parameters is conducted. Experiments and simulations match very well qualitatively, but with a slight quantitativity gap. The specificity of the thermal diffuse scattering cross-section, not available in the simulation, is thought to be responsible for this gap. Beside Kikuchi diffraction, the case of diffraction spots and diffuse background present in the pattern is also discussed.
Personal votes, electoral competitiveness of parties, and legislative representation in Taiwan under SNTV
Authors: Jang Jinhyeok , Lin Nick C. N. 
Published: December 2018

AbstractWe advance the literature on electoral institutions and legislative representation by investigating legislators’ position taking strategies in Taiwan under the single non-transferable voting period. Existing research largely assumes that representatives elected from the same electoral rule behave similarly. We challenge this conventional understanding by arguing that legislators in multi-member districts (MMDs) tend to move toward the extreme direction from the party line if they come from districts where their party is less competitive. This pattern of legislative representation allows them to appeal to partisan voters, as lowering one's partisan profile can be too costly in such districts. On the contrary, those who are elected from strong partisan districts are expected to deviate from the party toward the moderate direction. Given a solid partisan foundation in these districts, these legislators may target voters across party lines. Our analysis covering the entire period of MMD elections after Taiwan's democratization (1992–2008) provides robust empirical evidence to our theoretical claim. Our findings, therefore, shed lights for future studies on the intertwining nature between electoral systems, district level factors, and legislative representation.
CARNAP’S DEFENSE OF IMPREDICATIVE DEFINITIONS
Authors: FLOCKE VERA 
Published: December 2018

AbstractA definition of a propertyPisimpredicativeif it quantifies over a domain to whichPbelongs. Due to influential arguments by Ramsey and Gödel, impredicative mathematics is often thought to possess special metaphysical commitments. The reason is that an impredicative definition of a propertyPdoes not have its intended meaning unlessPexists, suggesting that the existence ofPcannot depend on its explicit definition. Carnap (1937 [1934], p. 164) argues, however, that accepting impredicative definitions amounts to choosing a “form of language” and is free from metaphysical implications. This article explains this view in its historical context. I discuss the development of Carnap’s thought on the foundations of mathematics from the mid-1920s to the mid-1930s, concluding with an account of Carnap’s (1937 [1934]) non-Platonistic defense of impredicativity. This discussion is also important for understanding Carnap’s influential views on ontology more generally, since Carnap’s (1937 [1934]) view, according to which accepting impredicative definitions amounts to choosing a “form of language”, is an early precursor of the view that Carnap presents in “Empiricism, Semantics and Ontology” (1956 [1950]), according to which referring to abstract entities amounts to accepting a “linguistic framework”.
Ionospheric D Region Remote Sensing Using ELF Sferic Group Velocity
Authors: Gołkowski M. , Sarker S. R. , Renick C. , Moore R. C. , Cohen M. B. , Kułak A. , Młynarczyk J. , Kubisz J. 
Published: December 2018

AbstractThe lowest region of the ionosphere, the D region, plays an important role in magnetosphere‐ionosphere coupling but is challenging to directly observe. The group velocity of the extremely low frequency (ELF; 3–300 Hz) portion of lightning induced electromagnetic radiation can be used to diagnose the D region electron density profile. Day‐night conditions can be assessed using ELF receivers and lightning detection networks. Analytical formulations and the Long Wave Propagation Capability software package show that ELF group velocity has particular sensitivity to the sharpness of the exponential electron density profile. Applying the technique to sudden ionospheric disturbances shows that the group velocity increases in response to incidence of solar X‐ray flux . A small number of ELF receivers can provide a large‐scale diagnostic of the D region. ELF remote sensing using lightning is complementary to very low frequency remote sensing and can be used to assess the Earth‐ionosphere propagation channel for very low frequency transmitters.
High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization
Authors: Zhang Wei , Li Yanxiu , Nguyen Van Phuc , Huang Ziyi , Liu Zhipeng , Wang Xueding , Paulus Yannis M. 
Published: December 2018

AbstractPhotoacoustic microscopy (PAM) is an emerging imaging technology that can non-invasively visualize ocular structures in animal eyes. This report describes an integrated multimodality imaging system that combines PAM, optical coherence tomography (OCT), and fluorescence microscopy (FM) to evaluate angiogenesis in larger animal eyes. High-resolution in vivo imaging was performed in live rabbit eyes with vascular endothelial growth factor (VEGF)-induced retinal neovascularization (RNV). The results demonstrate that our multimodality imaging system can non-invasively visualize RNV in both albino and pigmented rabbits to determine retinal pathology using PAM and OCT and verify the leakage of neovascularization using FM and fluorescein dye. This work presents high-resolution visualization of angiogenesis in rabbits using a multimodality PAM, OCT, and FM system and may represent a major step toward the clinical translation of the technology.
Self-healable electroluminescent devices
Authors: Liang Guojin , Liu Zhuoxin , Mo Funian , Tang Zijie , Li Hongfei , Wang Zifeng , Sarangi Venkateshwarlu , Pramanick Abhijit , Fan Jun , Zhi Chunyi 
Published: December 2018

AbstractElectroluminescent (EL) devices have been extensively integrated into multi-functionalized electronic systems in the role of the vitally constituent light-emitting part. However, the lifetime and reliability of EL devices are often severely restricted by concomitant damage, especially when the strain exceeds the mechanical withstanding limit. We report a self-healable EL device by adopting a modified self-healable polyacrylic acid hydrogel as the electrode and a self-healable polyurethane as a phosphor host to realize the first omni-layer-healable light-emitting device. The physicochemical properties of each functionalized layer can be efficiently restored after experiencing substantial catastrophic damage. As a result, the luminescent performance of the self-healable EL devices is well recovered with a high healing efficiency (83.2% for 10 healing cycles at unfixed spots, and 57.7% for 20 healing cycles at a fixed spot). In addition, inter-device healing has also been developed to realize a conceptual “LEGO”-like assembly process at the device level for light-emitting devices. The design and realization of the self-healable EL devices may revive their performance and expand their lifetime even after undergoing a deadly cut. Our self-healable EL devices may serve as model systems for electroluminescent applications of the recently developed ionically conductive healable hydrogels and dielectric polymers.
Marine probiotics: increasing coral resistance to bleaching through microbiome manipulation
Authors: Rosado Phillipe M , Leite Deborah C A , Duarte Gustavo A S , Chaloub Ricardo M , Jospin Guillaume , Nunes da Rocha Ulisses , Saraiva João P , Dini-Andreote Francisco , Eisen Jonathan A , Bourne David G , Peixoto Raquel S 
Published: December 2018

Abstract
Although the early coral reef-bleaching warning system (NOAA/USA) is established, there is no feasible treatment that can minimize temperature bleaching and/or disease impacts on corals in the field. Here, we present the first attempts to extrapolate the widespread and well-established use of bacterial consortia to protect or improve health in other organisms (e.g., humans and plants) to corals. Manipulation of the coral-associated microbiome was facilitated through addition of a consortium of native (isolated from Pocillopora damicornis and surrounding seawater) putatively beneficial microorganisms for corals (pBMCs), including five Pseudoalteromonas sp., a Halomonas taeanensis and a Cobetia marina-related species strains. The results from a controlled aquarium experiment in two temperature regimes (26 °C and 30 °C) and four treatments (pBMC; pBMC with pathogen challenge – Vibrio coralliilyticus, VC; pathogen challenge, VC; and control) revealed the ability of the pBMC consortium to partially mitigate coral bleaching. Significantly reduced coral-bleaching metrics were observed in pBMC-inoculated corals, in contrast to controls without pBMC addition, especially challenged corals, which displayed strong bleaching signs as indicated by significantly lower photopigment contents and Fv/Fm ratios. The structure of the coral microbiome community also differed between treatments and specific bioindicators were correlated with corals inoculated with pBMC (e.g., Cobetia sp.) or VC (e.g., Ruegeria sp.). Our results indicate that the microbiome in corals can be manipulated to lessen the effect of bleaching, thus helping to alleviate pathogen and temperature stresses, with the addition of BMCs representing a promising novel approach for minimizing coral mortality in the face of increasing environmental impacts.
NR2C2-uORF targeting UCA1-miR-627-5p-NR2C2 feedback loop to regulate the malignant behaviors of glioma cells
Authors: Fan Zirong , Zheng Jian , Xue Yixue , Liu Xiaobai , Wang Di , Yang Chunqing , Ma Jun , Liu Libo , Ruan Xuelei , Wang Zhenhua , Liu Yunhui 
Published: December 2018

AbstractAccumulating evidence has highlighted the potential role of non-coding RNAs (ncRNAs) and upstream open-reading frames (uORFs) in the biological behaviors of glioblastoma. Here, we elucidated the function and possible molecular mechanisms of the effect of some ncRNAs and NR2C2-uORF on the biological behaviors of gliomas. Quantitative real-time PCR was conducted to profile the cell expression of lnc-UCA1 and microRNA-627-5p (miR-627-5p) in glioma tissues and cells. Western blot assay was used to determine the expression levels of NR2C2, SPOCK1, and NR2C2-uORF in glioma tissues and cells. Stable knockdown of lnc-UCA1 or overexpression of miR-627-5p in glioma cell lines (U87 and U251) were established to explore the function of lnc-UCA1 and miR-627-5p in glioma cells. Further, Dual luciferase report assay was used to investigate the correlation between lnc-UCA1 and miR-627-5p. Cell Counting Kit-8, transwell assays, and flow cytometry were used to investigate lnc-UCA1 and miR-627-5p function including cell proliferation, migration and invasion, and apoptosis, respectively. ChIP assays were used to ascertain the correlations between NR2C2 and SPOCK1 as well as NR2C2 between lnc-UCA1. This study confirmed that lnc-UCA1 was up-regulated in glioma tissues and cells. UCA1 knockdown inhibited the malignancies of glioma cells by reducing proliferation, migration, and invasion, but inducing apoptosis. We found that lnc-UCA1 acted as miR-627-5p sponge in a sequence-specific manner. Meanwhile, upregulated lnc-UCA1 inhibited miR-627-5p expression. In addition, miR-627-5p targeted 3′UTR of NR2C2 and down-regulated its expression. Moreover, UCA1 knockdown impaired NR2C2 expression by upregulating miR-627-5p. An uORF was identified in mRNA 5'UTR of NR2C2 and overexpression of whom negatively regulated NR2C2 expression. Remarkably, lnc-UCA1 knockdown combined with uORF overepression and NR2C2 knockdown led to severe tumor suppression in vivo. This study demonstrated that the NR2C2-uORF impaired the pivotal roles that UCA1-miR-627-5p-NR2C2 feedback loop had in regulating the malignancies of glioma cells by targeting NR2C2 directly. And this may provide a potential therapeutic strategy for treating glioma.
p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton
Authors: Fuertes-Alvarez Sandra , Maeso-Alonso Laura , Villoch-Fernandez Javier , Wildung Merit , Martin-Lopez Marta , Marshall Clayton , Villena-Cortes Alberto J. , Diez-Prieto Inmaculada , Pietenpol Jennifer A. , Tissir Fadel , Lizé Muriel , Marques Margarita M. , Marin Maria C. 
Published: December 2018

AbstractPlanar cell polarity (PCP) and intercellular junctional complexes establish tissue structure and coordinated behaviors across epithelial sheets. In multiciliated ependymal cells, rotational and translational PCP coordinate cilia beating and direct cerebrospinal fluid circulation. Thus, PCP disruption results in ciliopathies and hydrocephalus. PCP establishment depends on the polarization of cytoskeleton and requires the asymmetric localization of core and global regulatory modules, including membrane proteins like Vangl1/2 or Frizzled. We analyzed the subcellular localization of select proteins that make up these modules in ependymal cells and the effect of Trp73 loss on their localization. We identify a novel function of the Trp73 tumor suppressor gene, the TAp73 isoform in particular, as an essential regulator of PCP through the modulation of actin and microtubule cytoskeleton dynamics, demonstrating that Trp73 is a key player in the organization of ependymal ciliated epithelia. Mechanistically, we show that p73 regulates translational PCP and actin dynamics through TAp73-dependent modulation of non-musclemyosin-II activity. In addition, TAp73 is required for the asymmetric localization of PCP-core and global signaling modules and regulates polarized microtubule dynamics, which in turn set up the rotational PCP. Therefore, TAp73 modulates, directly and/or indirectly, transcriptional programs regulating actin and microtubules dynamics and Golgi organization signaling pathways. These results shed light into the mechanism of ependymal cell planar polarization and reveal p73 as an epithelial architect during development regulating the cellular cytoskeleton.
Long noncoding RNA ATB promotes the epithelial−mesenchymal transition by upregulating the miR-200c/Twist1 axe and predicts poor prognosis in breast cancer
Authors: Li Rong-Hui , Chen Min , Liu Jing , Shao Chang-Chun , Guo Cui-Ping , Wei Xiao-Long , Li Yao-Chen , Huang Wen-He , Zhang Guo-Jun 
Published: December 2018

AbstractRecent studies indicate that the long noncoding RNA ATB (lncATB) can induce the epithelial−mesenchymal transition (EMT) in cancer cells, but the specific cellular targets of lncATB require further investigation. In the present study, the upregulation of lncATB in breast cancer cells was validated in a TGF-β-induced EMT model. Gain- and loss-of-function studies demonstrated that lncATB enhanced cell migration, invasion and clonogenicity in vitro and in vivo. LncATB promoted the EMT by acting as a sponge for the miR-200 family and restoring Twist1 expression. Subsequently, the clinical significance of lncATB was investigated in a cohort of breast cancer patients (N = 131). Higher lncATB expression was correlated with increased nodal metastasis (P = 0.036) and advanced clinical stage (P = 0.011) as well as shorter disease-free survival (P = 0.043) and overall survival (P = 0.046). These findings define Twist1 as a major target of lncATB in the induction of the EMT and highlight lncATB as a biomarker in breast cancer patients.
Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16
Authors: Sagwal Sanjeev Kumar , Pasqual-Melo Gabriella , Bodnar Yana , Gandhirajan Rajesh Kumar , Bekeschus Sander 
Published: December 2018

AbstractMalignant melanoma is an aggressive cancer that develops drug resistance leading to poor prognosis. Efficient delivery of chemotherapeutic drugs to the tumor tissue remains a major challenge in treatment regimens. Using murine (B16) and human (SK-MEL-28) melanoma cells, we investigated traditional cytotoxic agents in combination with cold physical plasma-derived oxidants. We report synergistic cytotoxicity of doxorubicin and epirubicin, and additive toxicity of oxaliplatin with plasma exposure in coefficient of drug interaction analysis. The combination treatment led to an increased DNA damage response (increased phosphorylation of ATM, γ-H2AX foci, and micronuclei formation). There was also an enhanced secretion of immunogenic cell death markers ATP and CXCL10 in cell culture supernatants following combination treatment. The observed synergistic effects in tumor cells was due to enhanced intracellular doxorubicin accumulation via upregulation of the organic cationic transporter SLC22A16 by plasma treatment. The doxorubicin uptake was reversed by pretreating cells with antioxidants or calcium influx inhibitor BTP2. Endoribonuclease-prepared siRNAs (esiRNA)-mediated knockdown of SLC22A16 inhibited the additive cytotoxic effect in tumor cells. SK-MEL 28 and THP-1 monocytes co-culture led to greater THP-1 cell migration and SK-MEL-28 cytotoxicity when compared with controls. Taken together, we propose pro-oxidant treatment modalities to sensitize chemoresistant melanoma cells towards subsequent chemotherapy, which may serve as therapeutic strategy in combination treatment in oncology.
A novel lncRNA, TCONS_00006195, represses hepatocellular carcinoma progression by inhibiting enzymatic activity of ENO1
Authors: Yu Songman , Li Ning , Huang Zebing , Chen Ruochan , Yi Panpan , Kang Rui , Tang Daolin , Hu Xingwang , Fan Xuegong 
Published: December 2018

AbstractHepatocellular carcinoma (HCC) is one of the most common malignancies and has an unfavorable prognosis. The hepatitis B virus X (HBx) protein has been reported to be closely associated with hepatocarcinogenesis. Meanwhile, emerging evidence has indicated that long noncoding RNAs (lncRNAs) are involved in the pathogenesis and progression of cancers. Our previous investigation has demonstrated that HBx could promote HCC by regulating the expression levels of various lncRNAs. In this study, we identified an lncRNA, lncRNA-TCONS_00006195 (termed lncRNA-6195), which was downregulated in HBV-related HCC tissues compared with its expression in adjacent noncancerous hepatic tissues. Clinical data showed that a low level of lncRNA-6195 was correlated with a high Edmondson–Steiner grade of the tumor and a poor prognosis in HCC patients. Furthermore, lncRNA-6195 acted as a tumor repressor in the development of hepatitis B-related HCC, inhibiting HCC cell proliferation in vitro and in vivo. Moreover, lncRNA-6195 could combine with α-enolase (ENO1) and repress its enzymatic activity, thus further inhibiting the energy metabolism in HCC cells. Our results suggest that lncRNA-6195 represses the growth of HCC by inhibiting the enzymatic activity of ENO1. These findings provide new insights into the mechanisms underlying the lncRNA involvement in hepatocarcinogenesis and can serve as a basis for the development of novel strategies to hinder HCC.