bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal
Synaptic Plasticity in Rodent Model Psychosis: a Selective
Review
Authors: Bartsch Julia C. , Schott Björn H. , Behr Joachim 
Published: August 2019

AbstractSchizophrenia is a complex, heterogeneous psychiatric disorder that affects about
1% of the global population. Hippocampal dysfunction has been linked to both
cognitive deficits and positive symptoms in schizophrenia. Here, we briefly
review current findings on disrupted hippocampal processing from a clinical
perspective before concentrating on preclinical studies of aberrant hippocampal
synaptic plasticity using the N-methyl-D-aspartate receptor hypofunction model
of psychosis and related findings from genetic models. Taken together, the
results put the case for maladaptive hippocampal synaptic plasticity and its
extrinsic connections as mechanistic underpinnings of cognitive impairments in
schizophrenia.
Treatment of Olefinic Amides with NBS in Water: Synthesis of Monobromo- and Multibromobenzoxazines
Authors: Zhang Xu , Cao Wen-Bin , Xu Xiao-Ping , Ji Shun-Jun 
Published: August 2019

Treatment of olefinic amides with N-bromosuccinimide (NBS) in water is reported. Monobromobenzoxazines were mainly formed at room temperature, while at 80 °C multibromobenzoxazines were preferentially generated. Mechanism studies showed that the reaction might proceed via a cascade of electrophilic addition at the C=C bond followed by electrophilic substitution at the aromatic ring. No additives are required in this protocol.
Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry
Authors: Schellong Sebastian M. , Goldhaber Samuel Z. , Weitz Jeffrey I. , Ageno Walter , Bounameaux Henri , Turpie Alexander G. G. , Angchaisuksiri Pantep , Haas Sylvia , Goto Shinya , Zaghdoun Audrey , Farjat Alfredo , Nielsen Joern Dalsgaard , Kayani Gloria , Mantovani Lorenzo G. , Prandoni Paolo , Kakkar Ajay K. 
Published: August 2019

AbstractIsolated distal deep vein thrombosis (IDDVT) represents up to half of all lower limb DVT. This study investigated treatment patterns and outcomes in 2,145 patients with IDDVT in comparison with those with proximal DVT (PDVT; n = 3,846) and pulmonary embolism (PE; n = 4,097) enrolled in the GARFIELD-VTE registry. IDDVT patients were more likely to have recently undergone surgery (14.6%) or experienced leg trauma (13.2%) than PDVT patients (11.0 and 8.7%, respectively) and PE patients (12.7 and 4.5%, respectively). Compared with IDDVT, patients with PDVT or PE were more likely to have active cancer (7.2% vs. 9.9% and 10.3%). However, influence of provoking factors on risk of recurrence in IDDVT remains controversial. Nearly all patients (IDDVT, PDVT, and PE) were given anticoagulant therapy. In IDDVT, PDVT, and PE groups the proportion of patients receiving anticoagulant therapy was 61.4, 73.9, and 81.1% at 6 months and 45.8, 54.7, and 61.9% at 12 months. Over 12 months, the incidence of all-cause mortality, cancer, and recurrence was significantly lower in IDDVT patients than PDVT patients (hazard ratio [HR], 0.61 [95% confidence interval [CI], 0.48–0.77]; sub-HR [sHR], 0.60 [95% CI, 0.39–0.93]; and sHR, 0.76 [95% CI, 0.60–0.97]). Likewise, risk of death and incident cancer was significantly (both p < 0.05) lower in patients with IDDVT compared with PE. This study reveals a global trend that most IDDVT patients as well as those with PDVT and PE are given anticoagulant therapy, in many cases for at least 12 months.
Excitation energy-dependent photocurrent switching in a single-molecule photodiode
Authors: Shan Bing , Nayak Animesh , Williams Olivia F. , Yost Dillon C. , Polizzi Nicholas F. , Liu Yanming , Zhou Ninghao , Kanai Yosuke , Moran Andrew M. , Therien Michael J. , Meyer Thomas J. 
Published: August 2019

Significance
In optoelectronic devices based on the properties of molecular excited states, a major challenge exists in controlling wavelength-dependent properties, because of the rapid interconversion between excited states. In photoelectrochemical cells, based on dye-sensitized photoelectrodes, surface functionalization plays a significant role in directing the absorption and conversion of incident photons. We demonstrate here that the direction of photo-generated charge flow in an oxide-based photoelectrode can be controlled by varying the excited-state transitions in a surface-bound, highly conjugated supramolecular chromophore with important implications for photoelectrode design in molecular devices. This approach, with a well-established correlation between conjugated chromophores and oxide electrodes, can serve as an effective platform for further development of solar-energy conversion devices.
Health-Related Material Needs and Substance use among Emergency Department Patients
Authors: Gerber Evan , Gelberg Lillian , Rotrosen John , Castelblanco Donna , Mijanovich Tod , Doran Kelly M. 
Published: August 2019

Background: Emergency department (ED) visits related to substance use are common. ED patients also have high levels of health-related material needs (HRMNs), such as homelessness and food insecurity. However, little research has examined the intersection between ED patient HRMNs and substance use. Methods: We surveyed a random sample of public hospital ED patients. Surveys included validated single-item screeners for unhealthy alcohol and any drug use and questions on self-reported past-year material needs. We compared individual HRMNs and cumulative number of HRMNs by substance use screening status using bivariate and multivariable analyses. Results: A total of 2312 surveys were completed. Nearly one third of patients (32.3%, n = 747) screened positive for unhealthy alcohol use, and 21.8% ( n = 503) screened positive for drug use. Prevalence of HRMNs for all patients—including food insecurity (50.8%), inability to meet essential expenses (40.8%), cost barriers to medical care (24.6%), employment issues (23.8%), and homelessness (21.4%)—was high and was significantly higher for patients with unhealthy alcohol use or drug use. In multivariable analyses, homelessness was independently associated with unhealthy alcohol use (adjusted odds ratio [aOR]: 1.61, 95% confidence interval [CI]: 1.24–2.09) and drug use (aOR: 2.30, 95% CI: 1.74–3.05). There was a significant stepwise increase in the odds of patient unhealthy alcohol or drug use as number of HRMNs increased. Conclusions: ED patients with unhealthy alcohol or drug use have higher prevalence of HRMNs than those without. Our findings suggest that HRMNs may act additively and that homelessness is particularly salient. Patients’ comorbid HRMNs may affect the success of ED-based substance use interventions.
Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles
Authors: Clayton Aled , Boilard Eric , Buzas Edit I , Cheng Lesley , Falcón‐Perez Juan Manual , Gardiner Chris , Gustafson Dakota , Gualerzi Alice , Hendrix An , Hoffman Andrew , Jones Jennifer , Lässer Cecilia , Lawson Charlotte , Lenassi Metka , Nazarenko Irina , O'Driscoll Lorraine , Pink Ryan , Siljander Pia R‐M , Soekmadji Carolina , Wauben Marca , Welsh Joshua A , Witwer Ken , Zheng Lei , Nieuwland Rienk 
Published: August 2019

ABSTRACTThere is an increasing interest in exploring clinically relevant information that is present in body fluids, and extracellular vesicles (EVs) are intrinsic components of body fluids (“liquid biopsies”). In this report, we will focus on blood. Blood contains not only EVs but also cells, and non‐EV particles including lipoproteins. Due to the high concentration of soluble proteins and lipoproteins, blood, plasma and serum have a high viscosity and density, which hampers the concentration, isolation and detection of EVs. Because most if not all studies on EVs are single‐centre studies, their clinical relevance remains limited. Therefore, there is an urgent need to improve standardization and reproducibility of EV research. As a first step, the International Society on Extracellular Vesicles organized a biomarker workshop in Birmingham (UK) in November 2017, and during that workshop several working groups were created to focus on a particular body fluid. This report is the first output of the blood EV work group and is based on responses by work group members to a questionnaire in order to discover the contours of a roadmap. From the answers it is clear that most respondents are in favour of evidence‐based research, education, quality control procedures, and physical models to improve our understanding and comparison of concentration, isolation and detection methods. Since blood is such a complex body fluid, we assume that the outcome of the survey may also be valuable for exploring body fluids other than blood.
Computational phase-change memory: beyond von Neumann computing
Authors: Sebastian Abu , Le Gallo Manuel , Eleftheriou Evangelos 
Published: August 2019

Abstract
The explosive growth in data-centric artificial intelligence related applications necessitates a radical departure from traditional von Neumann computing systems, which involve separate processing and memory units. Computational memory is one such approach where certain tasks are performed in place in the memory itself. This is enabled by the physical attributes and state dynamics of the memory devices. Naturally, memory plays a central role in this computing paradigm for which emerging post-CMOS, non-volatile memory devices based on resistance-based information storage are particularly well suited. Phase-change memory is arguably the most advanced resistive memory technology and in this article we present a comprehensive review of in-memory computing using phase-change memory devices.
Design and feasibility of a flexible, on-body, high impedance coil receive array for a 1.5 T MR-linac
Authors: Zijlema Stefan E , Tijssen Rob H N , Malkov Victor N , van Dijk Luca , Hackett Sara L , Kok Jan G M , Lagendijk Jan J W , van den Berg Cornelis A T 
Published: August 2019

Abstract
The lack of radiation-attenuating tuning capacitors in high impedance coils (HICs) make HICs an interesting building block of receive arrays for MRI-guided radiotherapy (MRIgRT). Additionally, their flexibility and limited channel coupling allow for low-density support materials, which are likely to be more radiation transparent (radiolucent). In this work, we introduce the use of HICs in receive arrays for MRIgRT treatments. We discuss the design and show the dosimetric feasibility of a HIC receive array that has a high channel count and aims to improve the imaging performance of the 1.5 T MR-linac. Our on-body design comprises an anterior and posterior element, which each feature a

channel layout (32 channels total). The anterior element is flexible, while the posterior element is rigid to support the patient. Mockups consisting of support materials and conductors were built, irradiated, and optimized to minimize impact on the surface dose (7% of the dose maximum) and dose at depth (

0.8% under a single conductor and

1.4% under a conductor crossing). Anatomical motion and the use of multiple beam angles will ensure that these slight dose changes at depth are clinically insignificant. Subsequently, several functional, single-channel HIC imaging prototypes and a 5-channel array were built to assess the performance in terms of signal-to-noise ratio (SNR). The performance was compared to the clinical MR-linac array and showed that the 5-channel imaging prototype outperformed the clinical array in terms of SNR and channel coupling. Imaging performance was not affected by the radiation beam. In conclusion, the use of HICs allowed for the design of our flexible, on-body receive array for MRIgRT. The design was shown to be dosimetrically feasible and improved the SNR. Future research with a full array will need to show the gain in parallel imaging performance and thus acceleration.
General Assertions on the Gravitational Waves Polarization Modes from an f(R) Model of Gravity
Authors: Mebarki N. 
Published: August 2019

Abstract
Detailed analysis of an f( R) theory is emphasized in a Minkowski and non trivial background. It is shown that the polarization modes depend strongly on the metric or Palatini formalism, Einstein or Jordan frame, function f (R ), background gravitational field

g

μ
ν

0

and the observer.
Qualitative behaviour of gravitational perturbations in Chaplygin Gas - Unifying Dark Matter and Dark Energy
Authors: Zaidi Abdeldjalil , de Carvalho J.P.M. , Fernandes R.A.A. 
Published: August 2019

Abstract
Two unified models of dark matter (DM) and dark energy (DE) are analysed, namely the Generalized Chaplygin Gas and the Modified Chaplygin Gas models. We study the qualitative behaviour of gravitational perturbations in both models, analysing their dynamical systems which describe the linear density perturbations, and graphically show the wavenumber, or k-dependence of the solutions. Finally we compare the two models and try to conclude which of them is close to available observations.
UV fluorescence detection of extreme energy cosmic rays by the JEM-EUSO experiment
Authors: Bouhali Zohra , Djemil Taoufik , Sassane Khaoula 
Published: August 2019

Abstract
The Extreme Universe Space Observatory on the Japanese Experiment Module (JEM-EUSO) is a new experiment, based on an international collaboration of 16 countries, including Algeria. With the help of a space telescope embarked on the International Space Station (ISS), this experiment aims to observe extreme energy cosmic rays (EECR), above 5 · 1019 eV. Due to their very low flux, the study of these EECR is carried out indirectly by observing from space the extensive air showers (EAS) generated by the interaction of a primary particle with the upper atmosphere. The characteristics of these EAS allow us to go back to the characteristics of the primary particle, such as energy and arrival direction, by measuring the amount of fluorescence light emitted along their development. For this purpose, we have used an analytical method to estimate the amount of fluorescence photons detected by the JEM-EUSO space telescope for an incident proton of 1020 eV and a zenithal angle of 60°. Our results are compared to a more precise calculation using the EUSO Analysis and Simulation System (ESAF).
R-process 130Cd Waiting Point
Authors: Laouet N , Benrachi F 
Published: August 2019

Abstract
Most of the elements heavier than Fe in the universe were produced by the so-called r-process. Its mechanism is based on a rapid neutron capture by the nuclei, so that the neutron capture rates are much faster than those of β -decay. When r-process reaches nuclei with magic neutron numbers, the neutron separation or binding energies increase and the process slows down, it has to wait for several β decays to produce heavier nuclei. These magic nuclei are the waiting points. Information about r-process are steel missing and it requires knowledge of the nuclear structure of the neutron rich nuclei. However, the nuclear properties of these nuclei are not sufficiently well understood due to the experimental difficulties in their production. The A=130 isobars with N=82 present one of the most interesting waiting points, because of their positions far from β stability and near the doubly magic 132Sn core, for which theoretical and experimental studies give important information about beta decay half-lives. In this context, we focus on the study of even-even 130 Cd waiting point nuclear properties. We have performed some spectroscopic calculations for energetic spectrum, β -decay half-life evolution in terms of temperature, using recent experimental data, by means of Oxbash nuclear structure code. The getting spectrum is in a reasonably agreement with the available experimental data. However, the calculated β-decay half-life for the studied waiting point is short in comparison with the experimental one.
Harvesting big data from residential building energy performance certificates: retrofitting and climate change mitigation insights at a regional scale
Authors: Gouveia João Pedro , Palma Pedro 
Published: August 2019

Abstract
The reduction of energy consumption and the increase in energy efficiency is currently an important cornerstone of EU policy. Energy performance certificates (EPCs) were implemented as one of the tools to promote this agenda, and are used for the energy performance assessment of buildings. In this study, the characteristics of the Portuguese dwelling stock are regionally analysed using data from approximately 523,000 Portuguese residential EPCs. Furthermore, a bottom-up building typology approach is used to assess the regional energy needs impact of retrofitting actions and to estimate the heating and cooling energy performance gaps of the whole dwelling stock, as well as the potential CO2 emissions resulting from the gaps’ potential offset due to increase thermal comfort. The results show that Portuguese residential buildings have very low energy performance, with windows and roofs being identified as the most energy inefficient elements. Roof retrofitting has the highest potential for the reduction of energy needs. The estimated heating and cooling energy performance gap amount to very significant percentages, due to the poor performing building stock but also very low energy consumption levels, with probable consequences for the thermal comfort of occupants. Assuming the current energy mix, carbon emissions would be 9.8 and 20.2 times higher associated with heating and cooling, respectively, if the actual final energy consumption were to match the estimated theoretical values derived from building regulation. This study demonstrates several application cases and leverages the potential of the individual EPC, increasing the detail in the dwelling stock characterization and energy performance estimation, revealing its value for energy retrofit and climate change mitigation assessments, as well as establishing the ground for future work related to building retrofits, energy efficiency measure implementation, climate change mitigation, thermal comfort, and energy poverty studies.
Biodiversity Study on Segara Anakan Lagoon
Authors: Anrozi Royyan , Siagian Arjon , Restisha Vanny Apdila , Maretta Aldila 
Published: August 2019

Abstract
Segara Anakan is the only estuary on the southern coast and the widest mangrove ecosystem in Java Island. However, it is currently not included in the list of government protected conservation area. This study aims to identify the biodiversity in Segara Anakan conservation area. The results of this identification show the types of flora, fauna and their conservation status in a biodiversity profile. The results of this study showed that Segara Anakan conservation area is 16,253.2 ha with mangrove ecosystem as it main ecosystem. The total area of mangrove is 3,980 ha. There are 60 species of mangrove plants, one of them has a “near threatened” status according to the IUCN Red List (i.e. Ceriops decandra). According to the IUCN Red List, two birds are on “vulnerable” and one mammal has a “near threatened” conservation status. From the Shannon-Wiener biodiversity index calculation, the biodiversity level of the Segara Anakan Lagoon is categorized as a medium with the value 1.76 - 2.80. The Segara Anakan community also uses mangroves for processed food and batik colouring which can generate group turnover of around 2 to 3 million rupiahs per month.
Community Structure of Plankton at Central Kalimantan Peat Swamp Area
Authors: Pratiwi Niken T M 
Published: August 2019

Abstract
Land opening activities for agricultural purposes in Central Kalimantan peat swamp area lead the change of water quality. There will be a different pattern of hydrology between wet and dry season that will influence the existence of plankton. The aim of the study was to understand the plankton community structure of Central Kalimantan peat swampin two different seasons, the wet and dry season. The research was carried out by taking samples for water quality and plankton observation in eight sites. The data analysis consisted of spatial clustering analysis based on Canberra Index of water quality, diversity index, and PCA of plankton community and water quality relationship. The result showed that there were separately clustered channel waters between natural and artificial; with 56 and 36 species of phytoplankton, and zooplankton, respectively. The numbers of species were higher in wet season than in dry season. The most different conditions between the seasons were water current velocity and depth of waters. The plankton communities were highly correlated to depth, conductivity, and water current condition.
The role of Aksu Zhabagly Biosphere Reserve in the bird conservation of West Tien Shan
Authors: Ilina V 
Published: August 2019

Abstract
The territory of Aksu Zhabagly has a high degree of representativeness at regional level. Aksu Zhabagly Biosphere Reserve has about 75% of total biodiversity of West Tien Shan. It has 72.5% of vertebrates. The ornithofauna of West Tien Shan consists of 415 species, including 210 nesting species and 205 migrating and wintering species. The bird fauna of Aksu Zhabagly Biosphere Reserve includes 306 species (73,7 %) as well as 152 nesting species (72,3 %) and 154 migrating and wintering species (75,1 %). The basis of nesting avifauna is formed of passerine birds (83 species). Besides nesting birds, the nature reserve’s territory is habitat for at least 137 species in not-nesting period - in winter and during seasonal migrations in spring and autumn. There are 25 rare bird species (75,7%) from 33 species in West Tien Shan.
Optimization of Dyes Production by Mixed Aspergillus and Paecilomyces and Its Coloring on Cotton Cloth
Authors: Suciatmih  
Published: August 2019

Abstract
The present study aimed to optimize dyes of mixed Aspergillus and Paecilomyces and to evaluate dyes of the fungi in coloring cotton cloth. Different initial pH values (3, 5, 7, and 9), temperatures (24, 27, and 30°C), carbon sources (lactose, glucose, and sucrose,) and nitrogen sources (monosodium glutamate, potassium nitrate, sodium nitrate, and yeast extract) of the medium related to dyes and biomass production; and they coloring on cotton cloth were analysed. The optimum culture conditions for the dyes production by the mixed fungi was achieved at pH 9 (4.074 ± 0.0621 UA/L), a temperature of 24°C (4.4145 ± 0.1530 UA/L), with sucrose (4.1503 ± 0.0711 UA/L) as a carbon source, and sodium nitrate (4.0730 ± 0.0459 UA/L) as a nitrogen source, while for the maximum biomass production was obtained at pH 5 (3.7303 ± 0.1432 g/L), a temperature of 30°C (4.2997 ± 0.0372 g/L), with sucrose (2.965 ± 0.5431 g/L) as a carbon source, and monosodium glutamate (4.2697 ± 0.2843 g/L) as a nitrogen source. Culture conditions generated various shades on cotton cloth dyed with the fungal dyes. The intensity of color produced on the dyed cotton cloth by the fungal dyes was in line with the concentration of the dyes.