bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prevalence and the Increasing Significance ofGuanxi
Authors: Bian Yanjie 
Published: April 2018

AbstractThis paper provides an analytical review of the social science literature onguanxi. The focus of this review is on the prevalence and the increasing significance ofguanxiduring China's post-1978 reforms, which were implemented to move the country towards a market economy. Since then, researchers have engaged in debates on whatguanxiactually means to Chinese people in the past and today, how it has been adaptive to ongoing institutional transformations, and why its influence in economic, social, and political spheres can stabilize, increase or decrease with market reforms and economic growth. The author provides a synthesis of these debates before offering a theoretical framework which provides an understanding of the dynamics ofguanxithrough the changing degrees of institutional uncertainty and market competition. Survey findings on the increasing use ofguanxiin labour markets from 1978 to 2009 are presented to illustrate the usefulness of this framework. In the conclusion, the author argues thatguanxiis a five-level variable, and that the nature and forms ofguanxiinfluence are contingent upon whetherguanxiis a tie of connectivity, a sentimental tie, a sentiment-derived instrumental tie, an instrumental-particular tie, or an obligational tie that facilitates power and money exchanges. This five-level conceptualization is aimed at advancing future scholarship ofguanxiin China's rapidly changing society.
Orthopedic Knowledge and Need in the Provincial Philippines: Pilot Study of a Population-Based Survey
Authors: Courtney Christopher S. , Kirsch Thomas D. 
Published: April 2018

AbstractIntroductionInterventions to reduce disability from acute orthopedic injuries require a primary assessment of knowledge and need. There are no previous studies to assess this need in the remote provincial islands of the Philippines, an area recurrently affected by natural disaster.ProblemA preliminary assessment of orthopedic knowledge and need was performed to be expanded for regional or national implementation.MethodsTwo independent surveys were conducted of households and mid-level providers who represent the first contact of care. The goal of the survey was to describe the local health care system, to identify barriers to care, and to assess gaps in knowledge for acute traumatic orthopedic injuries. Both surveys were conducted in June of 2015.Population proportional sampling assessed a total of 100 households from 25 local Barangay communities. Questions focused on existing knowledge of acute traumatic orthopedic injuries and barriers to care.The mid-level provider survey focused on knowledge and barriers to care regarding acute traumatic orthopedic injuries. A total of 10 school nurses and Barangay midwives representing 25 local Barangay were surveyed.ResultsIn the household population survey, 84% of respondents reported cost was either always or sometimes a barrier to care; 73% cited transportation as a barrier to care. A total of 68% of respondents reported that they would seek care at the provincial hospital for a suspected broken bone; 28% percent of respondents did not believe broken bones making an arm or leg crooked could be corrected without surgery. Only 55% percent believed care should be sought within six hours of injury, and 37% stated that more than three days after an injury was an appropriate timeframe to seek care.Of the mid-level providers surveyed, 90% reported that they would refer possible broken bones to a higher level of care. Aggregate ranking of barriers to care from greatest to least were: cost, transportation, knowledge of time sensitive nature of treatment, religious beliefs, and other (not specified). In all, 100% reported that an education initiative regarding acute orthopedic injuries would increase the number of patients seeking care within 12 hours.ConclusionThe survey describes perceived barriers to care and gaps in knowledge for acute orthopedic injuries. With some modification, this survey tool could be expanded and utilized on a regional or national level to assess gaps in knowledge and barriers to acute orthopedic care.CourtneyCS, KirschTD. Orthopedic knowledge and need in the Provincial Philippines: pilot study of a population-based survey. Prehosp Disaster Med. 2018;33(3):293–298.
Sleep patterns and sugar-sweetened beverage consumption among
children from around the world
Authors: Chaput Jean-Philippe , Tremblay Mark S , Katzmarzyk Peter T , Fogelholm Mikael , Hu Gang , Maher Carol , Maia Jose , Olds Timothy , Onywera Vincent , Sarmiento Olga L , Standage Martyn , Tudor-Locke Catrine , Sampasa-Kanyinga Hugues ,   for the ISCOLE Research Group
Published: April 2018

AbstractObjectiveTo examine the relationships between objectively measured sleep patterns
(sleep duration, sleep efficiency and bedtime) and sugar-sweetened beverage
(SSB) consumption (regular soft drinks, energy drinks, sports drinks and
fruit juice) among children from all inhabited continents of the world.DesignMultinational, cross-sectional study.SettingThe International Study of Childhood Obesity, Lifestyle and the Environment
(ISCOLE).SubjectsChildren (n 5873) 9–11 years of age.ResultsSleep duration was 12 min per night shorter in children who reported
consuming regular soft drinks ‘at least once a day’
compared with those who reported consuming ‘never’ or
‘less than once a week’. Children were more likely to
sleep the recommended 9–11 h/night if they reported
lower regular soft drink consumption or higher sports drinks consumption.
Children who reported consuming energy drinks ‘once a week or
more’ reported a 25-min earlier bedtime than those who reported
never consuming energy drinks. Children who reported consuming sports drinks
‘2–4 d a week or more’ also reported a
25-min earlier bedtime compared with those who reported never consuming
sports drinks. The associations between sleep efficiency and SSB consumption
were not significant. Similar associations between sleep patterns and SSB
consumption were observed across all twelve study sites.ConclusionsShorter sleep duration was associated with higher intake of regular soft
drinks, while earlier bedtimes were associated with lower intake of regular
soft drinks and higher intake of energy drinks and sports drinks in this
international study of children. Future work is needed to establish
causality and to investigate underlying mechanisms.
Carer and clinician perceptions of the use of emergency medical services by people with dementia: a qualitative study
Authors: Voss Sarah , Brandling Janet , Black Sarah , Cheston Rik , Cullum Sarah , Iliffe Steve , Purdy Sarah , Benger Jonathan 
Published: April 2018

Abstract
A growing number of older people are accessing emergency medical services (EMS), and many calls to EMS are made by, or on behalf of, people with dementia. Their needs are frequently complex; however, EMS staff are often given minimal guidance on ensuring patient safety, accurate diagnosis, and timely transfer to the most appropriate care. This study aimed to qualitatively explore the EMS experiences of carers for people with dementia and assess the views of EMS staff on the management of dementia, using focus groups and interviews. Themes were focussed on the circumstances surrounding EMS calls to people with dementia. These can prove frustrating due to a lack of information sharing, limited alternatives to hospital attendance and the amount of time that it can take to meet the complex needs of a person with dementia.
The Analogue Method Comes Unfastened – The Awkward Space between Market and Non-Market Economies in EC–Fasteners (Article 21.5)
Authors: ESPA ILARIA , LEVY PHILIP I. 
Published: April 2018

AbstractThe compliance Appellate Body decision marks the latest twist in the long-running EC–Fasteners dispute. The question before the AB is whether the European Union complied with earlier rulings on its anti-dumping procedures. Broadly, the AB found that the EU had not, generally ruling in favor of the People's Republic of China. In the process, the AB raised interesting questions about what it means to be a Non-Market Economy (NME) in the WTO. While NME status has traditionally led to large dumping margins, the AB approach in this case may lessen the consequences for China. Among other things, the case raises the interesting and important question of how pervasive the taint of NME status may be when calculating margins. By allowing for adjustments of certain costs, the AB seems to constrain the more draconian analogue country methodology of calculation.
Colombia – Measures Relating to the Importation of Textiles, Apparel and Footwear (DS461)
Authors: FRANCOIS JOSEPH , WHITTAKER JANET 
Published: April 2018

AbstractIn this paper, we examine the recent WTO dispute Colombia – Measures Relating to the Importation of Textiles, Apparel and Footwear. The dispute centers on the appropriate use of trade measures to target trade-related money laundering, the WTO consistency of such measures, and an ancillary question of appropriate time for remedies to be applied. The economics of the measures employed do not directly target the ostensible justification for the measures, while Colombia failed to convince the Panel and Appellate Body of key points related to the necessity of the measures taken. There has been success targeting trade-related money laundering following from cooperation of customs authorities and financial regulators to more directly target the agents involved. There may be a role for the WTO, in the form of steps taken to encourage such cooperation (as in Argentina – Measures Relating to Trade in Goods and Services). The basic lesson is that second best, blunt, and likely misdirected policies are not easily justified at the WTO, though more direct measures may be.
UNRAMIFIEDNESS OF GALOIS REPRESENTATIONS ATTACHED TO HILBERT MODULAR FORMS MOD OF WEIGHT 1
Authors: Dimitrov Mladen , Wiese Gabor 
Published: April 2018

The main result of this article states that the Galois representation attached to a Hilbert modular eigenform defined over $\overline{\mathbb{F}}_{p}$of parallel weight 1 and level prime to$p$is unramified above $p$. This includes the important case of eigenforms that do not lift to Hilbert modular forms in characteristic 0 of parallel weight 1. The proof is based on the observation that parallel weight 1 forms in characteristic $p$embed into the ordinary part of parallel weight $p$forms in two different ways per prime dividing $p$, namely via ‘partial’ Frobenius operators.
Population and quantitative genomic properties of the USDA soybean germplasm collection
Authors: Xavier Alencar , Thapa Rima , Muir William M. , Rainey Katy Martin 
Published: April 2018

AbstractThis study is the first assessment of the entire soybean [Glycine max(L.) Merr] collection of the United State Department of Agriculture National Plant Germplasm System (USDA) reporting quantitative and population genomic parameters. It also provides a new insight into soybean germplasm structure. Germplasm studies enable plant breeders to incorporate novel genetic resources into breeding pipelines to improve valuable agronomic traits. We conducted comprehensive analyses on the 19,652 soybean accessions in the USDA-ARS germplasm collection, genotyped with the SoySNP50 K iSelect BeadChip SNP array, to elucidate the quantitative properties of existing subpopulations inferred through hierarchical clustering performed with Ward'sDagglomeration method and Nei's standard genetic distance. We found the effective population size to be approximately 106 individuals based on the linkage disequilibrium of unlinked loci. The cladogram indicated the existence of eight major clusters. Each cluster displays particular properties with regard to major quantitative traits. Among those, cluster 3 represents the tropical and semi-tropical genetic material, cluster 5 displays large seeds and may represent food-grade germplasm, and cluster 7 represents the undomesticated material in the germplasm collection. The averageFSTamong clusters was 0.22 and a total of 914 SNPs were exclusive to specific clusters. Our classification and characterization of the germplasm collection into major clusters provides valuable information about the genetic resources available to soybean breeders and researchers.
Continent‐Ocean Transition Across the Northeastern Nova Scotian Margin From a Dense Wide‐Angle Seismic Profile
Authors: Lau K. W. H. , Nedimović Mladen R. , Louden Keith E. 
Published: April 2018

AbstractTo improve constraints on rifting processes resulting in the formation of the southeastern Canadian margin, we interpret the most detailed regional 2‐D velocity model from offshore Nova Scotia constructed using wide‐angle OETR‐2009 data. This 405‐km‐long profile was collected with 78 ocean bottom seismometers. The presented data analysis and interpretation are supported by a reflection image from the coincident long streamer GXT‐2000 profile. We identify a continental zone where the full‐thickness (~30 km), three‐layered continental crust beneath the inner shelf thins sharply seaward by a listric fault that forms a 12‐km‐deep Huron Subbasin beneath a high‐velocity carbonate bank (~5.8 km/s), creating a shadow zone above tilted crustal blocks. Depth‐dependent and variable initial thinning is evidenced in all three modeled crustal layers, which, nevertheless, pinch out together at their seaward ends. More gradual and regional thinning and a local amagmatic thickening are modeled seaward beneath the slope until 70 km from the shelf break, beyond which a deepwater amagmatic continent‐ocean transition shows velocity characteristics not typical of either continental or oceanic crust. The 100‐km‐wide continent‐ocean transition is characterized by a low‐velocity (5.3–5.4 km/s), low gradient, <2‐km thick upper crust, above a high‐velocity (6.3–7.5 km/s), high gradient, <5‐km‐thick lower crust, which can be interpreted as moderately serpentinized mantle. Underneath this layer is a <5‐km‐thick low‐velocity (7.1–8.0 km/s) partially serpentinized mantle layer. A ~5‐km‐thick oceanic crust is modeled seaward. Our results suggest that amagmatic processes dominated the continental breakup in this area.
Simulation of Wave‐Current Interactions Under Hurricane Conditions Using an Unstructured‐Grid Model: Impacts on Ocean Waves
Authors: Sun Yujuan , Perrie William , Toulany Bechara 
Published: April 2018

AbstractThe effect of wave‐current interactions on ocean waves under hurricane conditions is investigated through application of the unstructured‐grid finite‐volume community ocean model (FVCOM) coupled to the unstructured‐grid surface wave model (SWAVE) in the North Atlantic Ocean. We study wave‐current interactions during the life cycles of extratropical hurricanes Juan (2003) and Bill (2009) as they propagate from subtropical waters to midlatitudes in the Northwest Atlantic. Simulations of wave parameters in each hurricane are shown to compare well with buoy and satellite altimeter observations, in terms of winds, significant wave heights, wave energy spectra, and wave directions. This is partially achieved by restricting the drag coefficient. It is well known that the maximum intensity of tropical cyclones depends on the ratio of the enthalpy coefficient to the drag coefficient. The latter increases with wind speed, levels off with category one hurricanes and may drop for even higher winds. In our study, we find that setting a limiting value on the drag coefficient improves the simulations of waves at peak storm intensities. Simulation of wave‐current interactions is also shown to improve the simulation of the wave heights and wave energy spectra. This is notable at the peak of the storms, in comparisons with observations from buoys in areas of both deep water and relatively shallow water. The effect of currents on significant wave heights is shown to reach 0.4 m for hurricane Juan and 1.0 m for hurricane Bill, or as much as about ±10% for wave heights distributed along the storm track.
Characteristics of Water Vapor Turbulence Profiles in Convective Boundary Layers During the Dry and Wet Seasons Over Darwin
Authors: Osman M. K. , Turner D. D. , Heus T. , Newsom R. 
Published: April 2018

AbstractThis study explores water vapor turbulence in the convective boundary layer (CBL) using the Raman lidar observations from the Atmospheric Radiation Measurement site located at Darwin, Australia. An autocovariance technique was used to separate out the random instrument error from the atmospheric variability during time periods when the CBL is cloud‐free, quasi‐stationary, and well mixed. We identified 45 cases, comprising of 8 wet and 37 dry seasons events, over the 5‐year data record period. The dry season in Darwin is known by warm and dry sunny days, while the wet season is characterized by high humidity and monsoonal rains. The inherent variability of the latter resulted in a more limited number of cases during the wet season. Profiles of the integral scale, variance, coefficient of the structure function, and skewness were analyzed and compared with similar observations from the Raman lidar at the Atmospheric Radiation Measurement Southern Great Plains (SGP) site. The wet season shows larger median variance profiles than the dry season, while the median profile of the variance from the dry season and the SGP site are found to be more comparable particularly between 0.4 and 0.75 zi. The variance and coefficient of the structure function show qualitatively the same vertical pattern. Furthermore, deeper CBL, larger gradient of water vapor mixing ratio at zi, and the strong correlation with the water vapor variance at zi are seen during the dry season. The median value in the skewness is mostly positive below 0.6 zi unlike the SGP site.
Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity
Authors: Seong Hyun-A , Manoharan Ravi , Ha Hyunjung 
Published: April 2018

AbstractSmad proteins have been implicated in metabolic processes, but little is known about how they regulate metabolism. Because Smad 2, 3, 4, and 7 have previously been shown to interact with murine protein serine–threonine kinase 38 (MPK38), an AMP‐activated protein kinase (AMPK)-related kinase that has been implicated in obesity-associated metabolic defects, we investigated whether Smad proteins regulate metabolic processes via MPK38. Smads2/3/4 increased, but Smad7 decreased, MPK38-mediated apoptosis signal-regulating kinase-1 (ASK1)/transforming growth factor-β (TGF-β)/p53 signaling. However, MPK38-mediated phosphorylation-defective Smad mutants (Smad2 S245A, Smad3 S204A, Smad4 S343A, and Smad7 T96A) had no such effect. In addition, Smads2/3/4 increased, but Smad7 decreased, the stability of MPK38. Consistent with this, Smads2/3/4 attenuated complex formation between MPK38 and its negative regulator thioredoxin (Trx), whereas Smad7 increased this complex formation. However, an opposite effect was observed on complex formation between MPK38 and its positive regulator zinc-finger-like protein 9 (ZPR9). When Smads were overexpressed in high-fat diet (HFD)-fed obese mice using an adenoviral delivery system, Smads2/3/4 improved, but Smad7 worsened, obesity-associated metabolic parameters and inflammation in a MPK38 phosphorylation-dependent manner. These findings suggest that Smad proteins have class-specific impacts on obesity-associated metabolism by differentially regulating MPK38 activity in diet-induced obese mice.
LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling
Authors: Li Ailing , Peng Rui , Sun Yan , Liu Handeng , Peng Huimin , Zhang Zheng 
Published: April 2018

AbstractLong intergenic noncoding RNAs (lincRNAs) have been gradually identified to be functional in a variety of different mechanisms associating with development and epigenetic regulation of cellular homeostasis. However, the study of lincRNAs in diabetic nephropathy (DN) is still in its infancy. Here, we have found dysexpressed long noncoding RNAs (lncRNAs) in renal tissues of db/db DN mice compared with db/m mice by RNA sequencing. In this study, 5 lincRNAs were confirmed to express in a consistent trend among these DN-related lncRNAs both in vivo and in vitro. Particularly, 1700020I14Rik was the downregulated one. Moreover, our data showed overexpression or knockdown of 1700020I14Rik could regulate cell proliferation and fibrosis in mouse mesangial cells (MCs). Furthermore, 1700020I14Rik was found to interact with miR-34a-5p via both the directly targeting way by bioinformatic investigation and luciferase assay and the Ago2-dependent manner by RIP assay. Results also displayed that overexpression of 1700020I14Rik inhibited cell proliferation and expressions of renal fibrosis markers through miR-34a-5p/Sirt1/HIF-1α pathway in MCs under high glucose condition, while knockdown of 1700020I14Rik could increase cell proliferation and expressions of renal fibrosis markers. In conclusion, these results provide new insights into the regulation between 1700020I14Rik and miR-34a-5p/Sirt1/HIF-1α signaling pathway during the progression of DN.
The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells
Authors: Gu Yuting , Ding Xinyuan , Huang Jiefang , Xue Mingxing , Zhang Jie , Wang Qiwei , Yu Hongshuang , Wang Yanan , Zhao Fang , Wang Hui , Jin Min , Wu Yeming , Zhang Yanyun 
Published: April 2018

AbstractIt is known that proinflammatory cytokines empower multipotent mesenchymal stromal cells (MSCs) the immunosuppressive capacity to treat various inflammatory diseases. Nevertheless, how the proinflammatory cytokines modulate the immunosuppressive capacity of MSCs is poorly understood. In the present study, we identified that the deubiquitinating enzyme ubiquitin C-terminal hydrolase 1 (UCHL1) was upregulated in MSCs upon stimulation of proinflammatory cytokines IFN-γ plus TNF-α. Interestingly, through intervening UCHL1 by shRNA knockdown or its inhibitor LDN57444 or overexpression, we found that UCHL1 played a critical role in suppressing cytokines-induced inducible nitric oxide synthase expression in murine MSCs and indoleamine 2,3-dioxygenase expression in human MSCs, thereby restrained their immunosuppressive capacity. This effect of UCHL1 was attributed to the negative role in regulating NF-κB and STAT1 signaling, as exhibited by promoting NF-κB and STAT1 activation upon inhibition of UCHL1. Besides, inhibition of UCHL1 suppressed cytokines-induced MSC apoptosis via upregulation of Bcl-2. As a consequence, UCHL1-inhibited MSCs effectively alleviated concanavalin A-induced inflammatory liver injury. Therefore, our study demonstrates a novel role of UCHL1 in regulating the immunosuppressive capacity and survival of MSCs, which further affects their immunotherapy for inflammatory diseases.