bluuebunny/crossref_metadata_2025_split huggingface dataset:
HPV‐related oral dysplasia in a multiple myeloma patient after stem cell transplantation
Authors: Saleh Wafaa , Cha Seunghee , Indraneel Bhattacharyya , Moreb Jan , Katz Joseph 
Published: November 2018

AbstractThe development of dysplastic changes in oral epithelial lesions is a potential long‐term complication after hematopoietic stem cell transplantation (HSCT). This may be related to mechanisms including radiation and chemotherapy regimens, chronic graft‐versus‐host disease (cGVHD), inflammation, and prolonged immunosuppression. The current case describes a 54‐year‐old male with multiple myeloma treated by autologous and allogenic HSCT followed by development of cGVHD (mouth, skin and the eyes) with the complaint of diffuse white lesions on the buccal mucosa, tongue, and palate. A biopsy performed with histopathological analysis revealed moderate to severe epithelial dysplasia with hyperkeratosis, positive for p16INK4A as a surrogate marker for human papillomavirus (HPV). Our finding suggests a possible association of oral dysplasia and HPV in patients after receiving allogenic HSCT with the necessity of more clinical follow‐ups for those patients that may be at a higher risk for the development of oral dysplasia associated with HPV.
Early socialization of hostile attribution bias: The roles of parental attributions, parental discipline, and child attributes
Authors: Lee Sujin , Chang Hyein , Ip Ka I. , Olson Sheryl L. 
Published: November 2018

AbstractThe goal of this study was to examine child and parent predictors of children's hostile attribution bias (HAB) with a particular focus on exploring the associations between parents’ early attribution of child misbehavior and children's HAB in the transition to school age. Participants were 241 children (118 girls) of middle‐income families who were at risk for school‐age conduct problems. Multi‐method, multi‐informant data were collected on maternal attributions of child misbehavior, parental use of corporal punishment, and child attributes (i.e., verbal IQ, effortful control, theory of mind, and emotional understanding) at 3 years, and child HAB in ambiguous situations at 6 years. Results indicated that mothers’ internal explanations for children's misconduct may either reduce or increase children's later HAB depending on the specific content of attributions, such that mothers’ belief that children misbehave because of their internal state (i.e., emotional state or temperament) was associated with lower levels of child HAB, whereas attributing power‐based motives (i.e., manipulative, controlling intentions) in children was associated with higher levels of HAB. The findings are discussed with respect to appreciating the complexity of parents’ explanations for children's behavior, and considering parental cognition as a potential target for early identification and prevention of child HAB and related problems.
A Tortonian onset for the Algerian margin inversion: Evidence from low‐temperature thermochronology
Authors: Recanati Alice , Missenard Yves , Leprêtre Rémi , Gautheron Cécile , Barbarand Jocelyn , Abbassene Fatiha , Abdallah Nachida , Ouabadi Aziouz , Derder Mohamed El Messaoud , Boukari Claire , Pinna‐Jamme Rosella , Haurine Frédéric 
Published: November 2018

AbstractIn North Africa, the Algerian margin is made of basement blocks that drifted away from the European margin, namely the Kabylia, and docked to the African continental crust in the Early Miocene. This young margin is now inverted, as dated Miocene (17 Ma) granites outcrop alongshore, evidencing kilometre‐scale exhumation since their emplacement. Age of inversion is actually unknown, although Pliocene is often considered in the offshore domain. To decipher the exhumation history of the margin between 17 and 5 Ma, we performed a coupled apatite fission track (AFT) and (U–Th–Sm)/He (AHe) study in the Cap Bougaroun Miocene granite. AFT dates range between 7 ± 1 and 10 ± 1 Ma, and mean AHe dates between 8 ± 2 and 10 ± 1 Ma. These data evidence rapid and multi‐kilometre exhumation during Tortonian times. This event cannot be related to slab break‐off but instead to the onset of margin inversion that has since developed as an in‐sequence north‐verging deforming prism.
Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension
Authors: Shaw Brian I. , Nanavati Aditya J. , Taylor Vanessa , Miller Rachel A. , Kappus Matthew , Barbas Andrew S. 
Published: November 2018

AbstractThe unexpected transmission of donor‐derived infection through organ transplantation is a rare event with current donor screening practices. In this case report we describe a probable donor‐derived transmission of Herpes Simplex Virus (HSV)‐2 via deceased donor kidney transplantation resulting in HSV hepatitis in the recipient. This manifested as acute liver failure which resolved with appropriate anti‐viral therapy. Following recovery from the acute liver insult, the patient developed fibrotic liver morphology and portal hypertension, an unusual departure from the typical course.
Combining culture and microbead‐based immunoassay for the early and generic detection of bacteria in platelet concentrates
Authors: Vossier Ludivine , Valera Lionel , Leon Fanny , Roche Stéphanie , Piquer Dominique , Rubrecht Laetitia , Favier Christine , Cremer Gaelle‐Anne , Pouzet Agnès , Dagland Typhaine , Rihet Stéphane , Galea Pascale , Farre Carole , Bonnet Romaric , Jaffrézic‐Renault Nicole , Chaix Carole , Fareh Jeannette , Fournier‐Wirth Chantal 
Published: November 2018

BACKGROUNDDespite current preventive strategies, bacterial contamination of platelets is the highest residual infectious risk in transfusion. Bacteria can grow from an initial concentration of 0.03–0.3 colony‐forming units (CFUs)/mL up to 108 to 109 CFUs/mL over the product shelf life. The aim of this study was to develop a cost‐effective approach for an early, rapid, sensitive, and generic detection of bacteria in platelet concentrates.STUDY DESIGN AND METHODSA large panel of bacteria involved in transfusion reactions, including clinical isolates and reference strains, was established. Sampling was performed 24 hours after platelet spiking. After an optimized culture step for increasing bacterial growth, a microbead‐based immunoassay allowed the generic detection of bacteria. Antibody production and immunoassay development took place exclusively with bacteria spiked in fresh platelet concentrates to improve the specificity of the test.RESULTSAntibodies for the generic detection of either gram‐negative or gram‐positive bacteria were selected for the microbead‐based immunoassay. Our approach, combining the improved culture step with the immunoassay, allowed sensitive detection of 1 to 10 CFUs/mL for gram‐negative and 1 to 102 CFUs/mL for gram‐positive species.CONCLUSIONIn this study, a new approach combining bacterial culture with immunoassay was developed for the generic and sensitive detection of bacteria in platelet concentrates. This efficient and easily automatable approach allows tested platelets to be used on Day 2 after collection and could represent an alternative strategy for reducing the risk of transfusion‐transmitted bacterial infections. This strategy could be adapted for the detection of bacteria in other cellular products.
Slip Casting of Alumina for Membrane Application
Authors: Darunee B. , Tripob B. 
Published: November 2018

Porous alumina membranes were prepared from alumina matrix, polyvinyl alcohol binder (1–5%) and calcium carbonate additive (0–3%). The disc–shaped alumina samples were fabricated by slip casting process. The alumina paste was sintered at different temperatures of 1100, 1200, 1300 and 1400°C. The results showed that the porosity of the porous membrane reached 45%–46% at 1300°C sintering for the mixtures of alumina matrix with 3% PVA and alumina matrix with 2% CaCO3 plus 3% PVA. The water permeability was 150 L/m2.h at 20 kPa and the hydraulic conductivity coefficient was 1.06 × 10–9 – 2.43 × 10–9 ms–1Pa–1. The density, linear shrinkage water absorption and mechanical strength were ca. 3.92 g/cm3, 1.61–1.71% and 20.45–21.92%, 17.26–21 MPa, respectively. The SEM micrographs of alumina membrane using PVA binder showed a dense surface layers. An increase of the PVA binder resulted in a higher pure water fluxes and bigger pore sizes. An increase of CaCO3 in a 3% PVA binder mixtures resulted in a little decrease of porosity but increase in linear shrinkage from 1.57 to 2.04% at 1300°C sintering.
Computer-Assisted Three-Dimensional Corrective Osteotomy for Malunited Fractures of the Distal Radius Using Prefabricated Bone Graft Substitute
Authors: Shintani Kosuke , Kazuki Kenichi , Yoneda Masahiro , Uemura Takuya , Okada Mitsuhiro , Takamatsu Kiyohito , Nakamura Hiroaki 
Published: November 2018

Background: Three-dimensional computed tomography (3D-CT) imaging has enabled more accurate preoperative planning. The purpose of this study was to investigate the results of a novel, computer-assisted, 3D corrective osteotomy using prefabricated bone graft substitute to treat malunited fractures of the distal radius.Methods: We investigated 19 patients who underwent the computer-assisted 3D corrective osteotomy for a malunited fracture of the distal radius after the operation was stimulated with CT data. A prefabricated bone graft substitute corresponding to the patient’s bone defect was implanted and internal fixation was performed using a plate and screws. We compared postoperative radiographic parameters of the patient’s operated side with their sound side and analyzed clinical outcomes using Mayo wrist score.Results: All patients achieved bone union on X-ray imaging at final follow-up. The mean differences of palmar tilt, radial inclination and ulnar variance between the operation side and the sound side were 4.3°, 2.3° and 1.2 mm, respectively. The Mayo wrist score was fair in 4 patients and poor in 15 patients before surgery. At the final follow-up after surgery, the scores improved to excellent in 3 patients, good in 11 patients and fair in 5 patients. There were two patients with correction loss at the final follow-up, but no patient complained of hand joint pain.Conclusions: We believe that computer-assisted 3D corrective osteotomy using prefabricated bone graft substitute achieved good results because it worked as a guide to the accurate angle.
Flexor Tendon Injuries and Repairs: A Single Centre Experience
Authors: Chang Min Kai , Tay Shian Chao 
Published: November 2018

Background: Although flexor tendon injuries cause significant morbidities and socio-economic implications, there have been limited data on patient demographics, injury characteristics and surgical details. The aim of this study is to describe our experience in flexor tendon injuries and repairs.Methods: We performed a retrospective study of all digital flexor tendon injuries that were repaired from January 2011 to December 2014. The collected data included patient demographics, injury characteristics and surgical details.Results: A total of 214 patients, 308 digits with 446 flexor tendon repairs were identified. We found that males, non-residents, and 20–29 age group were most prone to flexor tendon injuries. Cleaners, labourers and related occupations were the most vulnerable. The mechanism of injury was usually work-related and mostly caused by glass. Most injuries involve both flexor digitorum profundus and flexor digitorum superficialis tendons. Concomitant digital nerve and vessel injuries were common. Most patients suffered zone 2 laceration of a single digit of the non-dominant hand. Most patients underwent procedures that lasted 1 to 2 hours, including multiple flexor tendon repairs, microsurgical repairs and other interventions.Conclusions: This study is the largest study on patient demographics, injury characteristics and surgical details on flexor tendon injuries and repairs. It could be used to plan resources and policies for the management and prevention of flexor tendon injuries.
Screw Length Optimization of a Volar Locking Plate Using Three Dimensional Preoperative Planning in Distal Radius Fractures
Authors: Totoki Yasukazu , Yoshii Yuichi , Kusakabe Takuya , Akita Kenichi , Ishii Tomoo 
Published: November 2018

Background: A three-dimensional (3D) digital pre-operative planning system for the osteosynthesis of distal radius fracture was developed. The objective of this study was to evaluate screw choices for three-dimensional (3D) digital pre-operative planning of osteosynthesis of distal radius fractures and to compare with the screw choices for the conventional method.Methods: Distal radius fracture patients who underwent osteosynthesis using volar locking plates were evaluated. Thirty wrists in the plan group utilized 3D preoperative planning, and nineteen wrists in the control group utilized conventional preoperative assessment. In the plan group, the 3D preoperative planning was performed prior to surgery. The reduction was simulated with 3D image, and the implant choice/placement also simulated on the 3D image. In the control group, standard preoperative planning was performed using posterior-anterior and lateral view radiographs, and CT scan. After the planning, osteosynthesis was performed. During the surgery, the operator performed the reduction and the placement of the plate while comparing images between the pre-operative plan and fluoroscopy. The distal screw lengths and the anteroposterior diameter of the radius along the axis of the distal screws were measured. The ratios of the screw length and radius diameter were evaluated. The screw/radius ratios within the range of 0.75–1.00 were considered appropriate. The screw choices less than 0.75, or greater than 1.00 were considered inappropriate. The rate of appropriate screw choices were compared between plan and control groups.Results: The results of appropriate screw choices were 86.1% and 74.8% in the plan group and the control group, respectively. The inappropriate screw choices were 14.0% and 25.2% in the plan group and the control group, respectively. The three-dimensional planning significantly increased appropriate screw choices compared to the conventional planning (p < 0.05).Conclusions: Three-dimensional digital preoperative planning is useful for the optimization of screw lengths in osteosynthesis of distal radius fractures.
Cadaveric Dissection of the Axillary Nerve: An Investigation of Extra-Muscular and Intra-Muscular Branching Patterns
Authors: Rastogi Pratik , Stewart David A. , Lawson Richard D. , Tremblay Dominique M. , Smith Belinda J. , Tonkin Michael A. 
Published: November 2018

Background: Variations in the axillary nerve branching patterns have been reported. The aim of the study is to investigate the extra- and intra-muscular course of the axillary nerve and quantify the regional innervation of the deltoid. Methods: In fresh frozen specimens, the origin of the axillary nerve from the posterior cord of the brachial plexus and its extra- and intra-muscular course were identified. Muscle dimensions, branching patterns and the distance from the axillary nerve origin to major branches were measured. The weights of muscle segments supplied by major branches of the axillary nerve were recorded. Results: Twenty-three cadaveric dissections were completed. The axillary nerve bifurcated within the quadrangular space in all cases. The mean distance from the origin to bifurcation of the axillary nerve was 39 ± 13 mm; from axillary nerve bifurcation to the teres minor branch was 13 ± 6 mm; and from axillary nerve bifurcation to the middle branch of anterior division was 26 ± 11 mm. The nerve to teres minor and superior lateral brachial cutaneous nerve originated from the posterior division or common trunk in all cases. No fibrous raphe were identified separating anterior, middle and posterior deltoid segments. The anterior division of axillary nerve supplied 85 ± 4% of the deltoid muscle (by weight). The posterior division supplied 15 ± 4% of the deltoid muscle (by weight). The posterior deltoid was supplied by both anterior and posterior divisions in 91.3% of cases. Conclusions: This study demonstrates a consistent branching pattern of the axillary nerve. The anterior division of the axillary nerve innervates all three deltoid segments in most instances (85% of the deltoid by weight). This study supports the concept of re-innervation of the anterior division alone in isolated axillary nerve injuries.
An Exploratory Study Using Semi-Tabular Plate in Zone II Flexor Tendon Repair
Authors: Wong Yoke-Rung , Jais Ita Suzana Mat , Chang Min-Kai , Lim Beng-Hai , Tay Shian-Chao 
Published: November 2018

Background: This study evaluated the feasibility of using a low-profile titanium (Ti) plate implant, also known as the Ti-button, for Zone II flexor tendon repair. We hypothesize that the use of the Ti-button can distribute the tensile force on the digital flexor tendons to achieve better biomechanical performance.Methods: Twenty lacerated porcine flexor tendons were randomly divided into two groups and repaired using Ti-button or 6-strand modified Lim-Tsai technique. Ultimate tensile strength, load to 2 mm gap force, and mode of failure were recorded during a single cycle loading test. We also harvested twelve fingers with lacerated flexor digitorum profundus tendons from six fresh-frozen cadaver hands and repaired the tendons using either Ti-button method or modified Lim-Tsai technique. A custom-made bio-friction measurement jig was used to measure the gliding resistance and coefficient of friction of the tendon sheath interface at the A2 pulley.Results: The ultimate tensile strength, load to 2 mm gap force, stiffness, and gliding resistance of the Ti-button repairs were 101.5 N, 25.7 N, 7.8 N/mm, and 2.2 N respectively. Ti-button repairs had significantly higher ultimate tensile strength and stiffness than the modified Lim-Tsai repair. However, Ti-button also increased the gliding resistance and coefficient of friction but there was no significant difference between the two repair techniques.Conclusions: Ti-button repair displayed comparable mechanical properties to the traditional repair in terms of 2-mm gap formation and gliding resistance, but with a stronger repair construct. Thus, this deepened our interest to further investigate the potential of using Ti-button implant in Zone II flexor tendon repair by studying both the mechanical and biochemical (tendon healing) properties in more in-depth.
Which Factors Affect the Rate of Surgery Performed in Patients with Carpal Tunnel Syndrome?
Authors: Lee Yo-Han , Kim Jihyeung , Cho Jaewoo , Lee Min Ho , Oh Sohee , Bae Kee Jeong 
Published: November 2018

Background: Carpal tunnel release is recommended when patients have positive electrophysiologic test and their symptoms are not resolved in spite of conservative treatment. However, only some of them eventually undergo the surgery. The purposes of this study, therefore, were to evaluate the rate of carpal tunnel release performed among the patients with positive electrophysiologic test, and to identify which factors were associated with the rate of the surgery. Methods: Subjects of this study were 865 wrists of 508 patients (90 males and 418 females) who were diagnosed as carpal tunnel syndrome between January 2013 and December 2016. The diagnosis of carpal tunnel syndrome was confirmed by electrophysiologic test, and only the patients who were followed up for more than 1 year were enrolled in this study. The average age at the time of the electrophysiologic test performed was 61.4 years, and the severity of carpal tunnel syndrome was evaluated according to the Bland scale (Gr 1–6) based on the electrophysiologic test. Whether or not the patients received carpal tunnel release was evaluated at the last follow-up visit. Results: Among the 865 wrists, carpal tunnel release was performed on 528 wrists (61%). Rate of the surgery performed significantly increased in patients with more severe grades on electrophyisiologic test. More patients in female (63.3%) than in male (50.3%) and more patients with age under 60 (67.5%) than age over 60 (57.1%) received the surgery. However, there was no significant difference in the rate of carpal tunnel release according to the bilaterality or dominant hand. Conclusions: The rate of carpal tunnel release among the patients diagnosed and confirmed as carpal tunnel syndrome was not higher than we expected. We should also pay more attention to the patients who did not undergo carpal tunnel release and investigate the reasons why those patients did not undergo surgery.
Fasting Plasma Glucose Indicates Reversibility of the Acute Insulin Response after Short-Term Intensive Insulin Therapy in Patients with Various Duration of Type 2 Diabetes
Authors: Liu Liehua , Yang Siyue , Liu Jianbin , Li Hai , Liu Juan , Cao Xiaopei , Xiao Haipeng , Li Yanbing 
Published: November 2018

Recovery of acute insulin response (AIR) is shown to be associated with long-term outcomes of patients with early type 2 diabetes treated with short-term intensive insulin therapy (SIIT). However, the complexity of measuring an AIR limits its utility in a real-world clinical setting. The aim of the study was to assess fasting indicators that may estimate recovery of the AIR after SIIT. We enrolled 62 patients with type 2 diabetes mellitus (T2DM) of varying disease duration who had poor glycemic control. Participants were treated with SIIT using insulin pumps to achieve near normoglycemia for 7 days. The AIR before and after the therapy were measured by intravenous glucose tolerance tests. After the therapy, AIR increased from −16.7 (−117.4, 52.4) pmol/L·min to 178.7 (31.8, 390.7) pmol/L·min (P<0.001) while hyperglycemia was alleviated; this improvement was observed in all disease duration categories. AIR was almost absent when fasting plasma glucose (FPG) > 10 mmol/L, while both AIR (R=−0.53, P<0.001) and its improvement from baseline (△AIR, R=−0.52, P<0.001) were negatively associated with FPG after SIIT when FPG < 10 mmol/L. In multivariate analyses, FPG after SIIT and baseline fasting C peptide were independent indicators of both AIR after the therapy and ∆AIR; HDL-C after the therapy also predicted AIR after the therapy. We concluded that recovery of the AIR could be obtained in T2DM patients of varying disease duration by SIIT and it could be conveniently estimated using posttreatment fasting plasma glucose and other fasting indicators.
O CONCEITO DE LIBERDADE E SUAS IMPLICAÇÕES POLÍTICAS. NOTAS SOBRE SIDNEY, LOCKE E A TRADIÇÃO REPUBLICANA
Authors: Hamel Christopher 
Published: November 2018

Neste artigo o autor relaciona os pensamentos políticos de Locke e Sidney para defender que Locke não pode ser inserido na tradição republicana da qual os escritos de Sidney fazem parte. Isto porque: 1) inexiste na teoria política lockeana uma visão de que a virtude cívica seja o suporte para instituições livres, tal como existe na referida tradição evocada por Sidney; 2) Locke reconhece o fundamento constitucional da prerrogativa do rei, o que para os republicanos, Sidney entre eles, é incompatível com a liberdade; 3) Locke retrata um povo excessivamente cordato e permissivo com o uso do poder por parte do governante, e também pouco disposto ao exercício do direito de resistência. Diferentemente, Sidney recorre à história para defender que os povos livres revelam as qualidades necessárias para conduzir essa resistência, já que o reconhecimento de que o governo de si mesmo e a resistência à tirania é uma questão de dignidade do homem como ser de liberdade.