bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mystery mass on the placenta
Authors: Ting Evelyn Lee Pian , Yong Soon Leong , Suhashini Ganapaty , Kang Marcus 
Published: October 2019

Abstract
Chorioangioma or chorangioma is a benign placental tumour which occurs in 1% of the pregnancies. Large lesions of more than 4–5 cm in size, also known as giant chorangiomas, are rare with the incidence of 1:3500 and 1:9000 birth. Unlike small tumours, the giant chorangiomas are highly associated with pregnancy complications. We report a case of multiple large chorangiomas resulting in an extremely preterm delivery. A 24-year-old primigravida presented at 25 weeks of gestation for threatened preterm labour. Transabdominal ultrasound revealed an echogenic mass on the placenta measuring 8.7 × 4.4 cm. Following a successful tocolysis and administration of a course of antenatal corticosteroids, she was discharged home. At 27 weeks of gestation, she developed a second episode of preterm contractions. Besides, the foetus was found to be small for gestational age. In the second episode of preterm contractions, intravenous magnesium sulfate infusion was commenced for foetal neuroprotection. Tocolysis was commenced for severe prematurity. She went into spontaneous preterm labour. Placenta examination revealed multiple solid masses with fleshy and congested dark red surface. A histopathological examination of the placenta confirmed the diagnosis of chorangiomas. The baby was discharged in good condition at 5 months of age. Placental chorangiomas, notably when they are multiple and large in size, are associated with adverse pregnancy outcomes. Therefore, close antenatal surveillance is necessary to allow timely recognition and intervention of pregnancy complications. Our case portrays an unexpected favourable neonatal outcome associated with a giant chorangiomas.
The use of atosiban prolongs pregnancy in patients treated with fetoscopic endotracheal occlusion (FETO)
Authors: Kosinski Przemyslaw , Luterek Katarzyna , Lipa Michal , Wielgos Miroslaw 
Published: October 2019

AbstractObjectiveTo evaluate the impact of atosiban as a tocolytic agent in patients treated with the fetoscopic endotracheal occlusion (FETO) procedure due to congenital diaphragmatic hernia (CDH). As premature birth after fetoscopy remains a serious concern, an effort to reduce prematurity is required.MethodsA total of 43 patients with severe CDH treated with FETO were enrolled in this study. The study group consisted of 22 patients who received atosiban during the FETO procedure and a control group of 21 patients who did not receive atosiban during the FETO procedure. Demographic data, gestational age (GA) at delivery, cervical length and GA at premature rupture of membranes (PROM) were evaluated.ResultsThe GA at delivery was significantly different between the two groups studied. The median GA at delivery was 32.6 and 34.5 weeks in the no-atosiban vs. atosiban groups, respectively (P = 0.013). The median cervical length was 29.9 and 31.2 mm for the no-atosiban and atosiban groups, respectively, and was not statistically significant (P = 0.28). There were no significant correlations between groups for the occurrence of PROM, GA at the time of PROM, duration of the procedures, parity, maternal body mass index (BMI) or age. In the univariate linear regression model, the only factor independently associated with GA at delivery was the use of atosiban during FETO procedures (β = 0.375; P < 0.013).ConclusionIn cases of severe CDH treated with FETO, the use of atosiban as a tocolytic agent during the procedure prolonged pregnancy by 2 weeks. Cervical length, duration of FETO or maternal characteristics were not associated with GA at delivery.
Identification and characterization of novel short-type BmPGRP-S4 from the silkworm, Bombyx mori, involved in innate immunity
Authors: Wang Qiang , Ren Meijia , Liu Xiaoyong , Xia Hengchuan , Chen Keping 
Published: October 2019

Abstract
Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that can recognize bacterial peptidoglycans and trigger the innate immune response of insects. Here, we identified and characterized a novel short-type Bombyx mori peptidoglycan recognition proteins short-4 (BmPGRP-S4) in a lepidopteran insect, Bombyx mori. BmPGRP-S4 exhibited a cDNA sequence length of 600 bp, encoding 199 aa with a protein molecular weight of 22 kDa. Multiple sequence alignment revealed that BmPGRP-S4 contains a conserved PGRP domain. Quantitative real-time polymerase chain reaction analysis showed that BmPGRP-S4 is highly expressed in the early developmental stages of silkworm larvae and presents tissue-specific expression in hemocytes. Interestingly, BmPGRP-S4 expression is significantly induced by bacterial infection in the midgut, fat body, and hemocytes. Furthermore, a dual luciferase reporter gene assay revealed that BmPGRP-S4 can activate the expression of the antimicrobial peptide genes lebocin, moricin, cecropin D, cecropin B, and attacin. Taken together, these results suggest that BmPGRP-S4 plays an important role in the innate immune response of silkworms.
A Scoping Review on Integrating Inorganic Nanomaterials into Cement Composites
Authors: Mahinroosta Mostafa , Allahverdi Ali 
Published: October 2019

Abstract
Today, nanomaterials have gained tremendous attention in various engineering fields. The prominent physicochemical properties of nanomaterials have made them promising and interesting options for application in construction and building materials. These applications range from structural reinforcement for development of cement composites with outstanding and multifunctional characteristics to production of self-compacting and self-cleaning materials. The incorporation of nanomaterials in cement composites leads to the enhancement of their physicomechanical properties and the induction of superior durability performance. The addition of nanomaterials diminish the formation of micropores by acting as a filling agent, generating a very compact and uniform matrix and automatically decreasing the growth of micropores in the matrix. Moreover, nanomaterials have great potential in diminishing the transport properties. It will also be demonstrated in this article that the strength gain of cement composites is directly associated with the packing and nucleation effect of nanomaterials. Within the scope of the current comprehensive review, general information and definitions of cement composites and nanotechnology are first elucidated. Then, the nanosized additives that greatly improve the characteristics of cement composites, such as nanosilica, nanoalumina, nano–titanium dioxide, nano–iron oxides, nano–zinc oxides, nano–magnesium oxide, and nano–copper oxide are discussed. Furthermore, the most important challenges and problems in the use of nanomaterials in cement composites are presented. The time scope placed on the review is from 2010 to early 2019.
The Pan-Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA
Authors: Disel Umut , Madison Russell , Abhishek Kumar , Chung Jon H. , Trabucco Sally E. , Matos Asli O. , Frampton Garrett M. , Albacker Lee A. , Reddy Venkataprasanth , Karadurmus Nuri , Benson Adam , Webster Jennifer , Paydas Semra , Cabanillas Ruben , Nangia Chaitali , Ozturk M.A. , Millis Sherri Z. , Pal Sumanta K. , Wilky Breelyn , Sokol Ethan S. , Gay Laurie M. , Soman Salil , Ganesan Shridar , Janeway Katherine , Stephens Phil J. , Zhu Viola W. , Ou Sai-Hong Ignatius , Lovly Christine M. , Gounder Mrinal , Schrock Alexa B. , Ross Jeffrey S. , Miller Vincent A. , Klempner Samuel J. , Ali Siraj M. 
Published: October 2019

Abstract

Purpose
Amplifications of receptor tyrosine kinases (RTKS) are therapeutic targets in multiple tumor types (e.g. HER2 in breast cancer), and amplification of the chromosome 4 segment harboring the three RTKs KIT, PDGFRA, and KDR (4q12amp) may be similarly targetable. The presence of 4q12amp has been sporadically reported in small tumor specific series but a large-scale analysis is lacking. We assess the pan-cancer landscape of 4q12amp and provide early clinical support for the feasibility of targeting this amplicon.

Experimental Design
Tumor specimens from 132,872 patients with advanced cancer were assayed with hybrid capture based comprehensive genomic profiling which assays 186–315 genes for all classes of genomic alterations, including amplifications. Baseline demographic data were abstracted, and presence of 4q12amp was defined as 6 or more copies of KIT/KDR/PDGFRA. Concurrent alterations and treatment outcomes with matched therapies were explored in a subset of cases.

Results
Overall 0.65% of cases harbored 4q12amp at a median copy number of 10 (range 6–344). Among cancers with &gt;100 cases in this series, glioblastomas, angiosarcomas, and osteosarcomas were enriched for 4q12amp at 4.7%, 4.8%, and 6.4%, respectively (all p &lt; 0.001), giving an overall sarcoma (n = 6,885) incidence of 1.9%. Among 99 pulmonary adenocarcinoma cases harboring 4q12amp, 50 (50%) lacked any other known driver of NSLCC. Four index cases plus a previously reported case on treatment with empirical TKIs monotherapy had stable disease on average exceeding 20 months.

Conclusion
We define 4q12amp as a significant event across the pan-cancer landscape, comparable to known pan-cancer targets such as NTRK and microsatellite instability, with notable enrichment in several cancers such as osteosarcoma where standard treatment is limited. The responses to available TKIs observed in index cases strongly suggest 4q12amp is a druggable oncogenic target across cancers that warrants a focused drug development strategy.
Urine Drug Testing in Cancer Pain Management
Authors: Arthur Joseph A. 
Published: October 2019

AbstractUrine drug test (UDT) is an effective tool used in chronic opioid therapy to ensure patient adherence to treatment and detect nonmedical opioid use. The two main types of UDT used in routine clinical practice are the screening tests or immunoassays and the confirmatory tests or laboratory-based specific drug identification tests such as gas chromatography–mass spectrometry, liquid chromatography–mass spectrometry, or tandem mass spectrometry. UDT produces objective data on some nonmedical opioid use that may otherwise go undetected, such as the use of undisclosed medications, the nonuse of prescribed medications, and the use of illegal drugs. It allows clinicians to initiate an open and effective conversation about nonmedical opioid use with their patients. However, the test has certain limitations that sometimes compromise its use. Its interpretation can be challenging to clinicians because of the complexity of the opioid metabolic pathways. Clear guidelines or recommendations regarding the use of UDT in cancer pain is limited. As a result, UDT appears to be underused among patients with cancer pain receiving opioid therapy. More studies are needed to help standardize the integration and use of UDT in routine cancer pain management.
Development of Modeling Algorithm of the Characteristics of the Steels in the Subsystem of Management of the Production Resources of Steel Production
Authors: Kochkovskaya S. S. 
Published: October 2019

The article is devoted to the development of an algorithm for modeling the characteristics of steels in accordance with customer requirements. A mathematical model is presented that takes into account the optimal levels of the main factors and their interaction, providing the required values of the characteristics. The next step in the study of the mathematical model was modeling by means of functional modeling methodology IDEF0. Input and output data, as well as normative documents of model management and mechanisms of this management for building a functional model are defined. The control mechanism was the software product OptimalSostav, developed using the object-oriented programming language Delphi. The software product is designed to simulate the characteristics of steels using the specified limits of permissible minimum and maximum values of mechanical properties. The algorithm of realization of the control mechanism, which is based on the fractional factor analysis, is described. The presented algorithm allows to identify the influence of chemical composition on the mechanical properties of steels in the form of mathematical and graphical dependencies and to determine the specified mechanical properties that meet the requirements of the customer. The main possibilities and the scope of the software product, which allows to solve the problem of predicting the optimal chemical composition, providing the required mechanical characteristics, as well as to adjust the process of steel melting within a given chemical composition to achieve the desired set of properties. The application of the software product on the example of the analysis of the influence of chemical elements on the mechanical properties of 75HMF roll steel is shown. The results of modeling in the form of mathematical and graphic dependences are given and the estimation of efficiency of application of the software product is given. The results of solving the problem of approximation of the obtained graphic dependences of the influence of chemical elements on the mechanical properties of the studied steel grade by means of Microsoft Excel are presented. It is established that the developed mathematical and algorithmic software of the software product allows to study the percentage of chemical elements in relation to the total composition of the alloy, based on the obtained pie charts and dependency graphs. The adequacy of the model is confirmed by experimental results.
To the question of the origin of the cultural assortment of Dagestan apricots through assessing the variability of leaf morphological characteristics
Authors: Anatov D. M. , Аsadulaev Z. M. , Osmanov R. M. , Akhmedova K. I. 
Published: October 2019

Aim. The paper presents the results of assessment of the indigenous nature and degree of similarity of apricot cultivars growing in the collection of the Mountain Botanical Garden, Gunib, Dagestan, Russia based on a comparative analysis of the variability of leaf morphological characteristics. Material and Methods. The material assessed consisted of 33 apricot cultivars of various ecological and geographical origins aggregated in the following groups: (a) Dagestan – traditional cultivars; (b) Moscow ‐ selection from the Tsytsin Main Moscow Botanical Garden, Russian Academy of Sciences based on wild forms of Tajikistan and Kyrgyzstan; (c) European and (d) Asian ‐ from Central Asia, Tajikistan, China and Altai. Results. The closeness of Dagestan and European varieties in comparison with Asian and Moscow varieties was shown. Most Dagestan (16 of 19) and European varieties have round‐shaped leaves (leaf shape index 80‐ 100%), while those from Asia and the Moscow Botanical Garden have leaves which are elongated elliptical and oval (60‐80%). Using the method of principal component analysis (PCA), it was established that most cultivars of Dagestan origin have similar leaf shapes and sizes, of which Tlama kurak (wide‐round), Hekobarsh (elongated) were distinguished by leaf shape and Esdelik by leaf size. Conclusion. Based on a discriminant analysis (Squared Mahalanobis Distances), it was found that the indices of indicators of leaf attributes (width/length of leaf lamina; petiole length/length of lamina; apex angle/corner of leaf base) are more reliable criteria for differentiating apricot varieties into ecological and geographical groups than their morphological characteristics.
The natural, historical and cultural heritage of the Dido basin and its mountain setting and its potential for the development of tourism and recreation
Authors: Ataev Z. V. , Gadzhibekov M. I. , Abdulaev K. A. , Radzhabova R. T. 
Published: October 2019

Aim. The article considers the potential of the natural, cultural and historical features of the territory of the Dido (Shaurinsky District) basin with its dramatic mountainous setting for the further development of tourism and recreation in regions of the highlands of the East Caucasus. Materials and Methods. In carrying out our study data obtained from field research, including a comprehensive environmental survey of the territory, were used. Field research included on‐site expeditions, profiling, descriptive, identification of key areas, mapping, photography. Historical sources, as well as stock imagery and existing cartographic material, were consulted. Results. The territory’s natural features and historical and cultural heritage were examined in terms of their attractiveness for tourist visits and an option of creating a recreational zone with tourist centres was articulated among other proposals for tourism and recreational development. Conclusion. The Dido basin with its high biological and landscape diversity and distinctive cultural and historical heritage presents significant potential for the development of various types of tourism and an associated local hospitality industry.
Modern application and prospects of the stable isotopes method for studying avian influenza A virus transmission in migratory birds
Authors: Druzyaka O. R. , Druzyaka A. V. , Gulyaeva M. A. , Huettmann F. , Shestopalov A. M. 
Published: October 2019

Aim. The circulation and transmission of pathogens is a global biological phenomenon that is closely associated with bird migration. This analysis was carried out with the aim of understanding and assessing the prospects of using the stable isotope method to study the circulation and transmission of the avian influenza A virus via migratory birds. Discussion. Insufficient data on the distances of migration of infected birds and their interpopulational relationships leaves open the question of the transmission of highly pathogenic influenza viruses (HSV) in the wild bird population. A deeper study of the role of migrations in the spread of HSV may possibly allow the more effective investigation of the transmission of the viral pathogen between individuals at migration stopover sites and the clarification of global migration routes. New methodological approaches are providing a more complete picture of the geography and phenology of migrations, as well as of the consequences of migratory behavior for species biology. The study of the quantitative component of migratory flows based on the analysis of the content of stable isotopes (SIMS) in bird tissues seems very promising. This method is being applied to the solution of various environmental issues, including the study of animal migrations. Conclusion. Based on data from the scientific literature, it is shown that SIMS is promising for the clarification of bird migration routes and the quantification of their intensity. The resolving power of the method is sufficient to determine the migration pathways of carriers of viral pathogens on the scale of zoogeographic subdomains and in even further detail. However, to date, there have been few such studies: in Russia they have not been conducted at all. The increased use of the SIMS methodology may possibly reveal new ways in which viral infections are spread via birds.
THE IMPACT OF VISIONARY LEADERSHIP, LEARNING ORGANIZATION AND INNOVATIVE BEHAVIOR TO PERFORMANCE OF CUSTOMS AND EXCISE FUNCTIONAL
Authors: Anshar Muhammad 
Published: October 2019

This research aims to determine the impact of visionary leadership, learning organization, and innovative behavior on the performance of Functional Officers of Customs and Excise Inspectors at Tanjung Priok Customs and Excise Main Service Office. The research was conducted at Tanjung Priok Customs and Excise Service Office using the number of samples of 78 Functional Officers of Customs and Excise Inspectors. The sample was selected using simple random sampling technique. Data collection was done by using questionnaire and data analysis using path analysis. The results showed that 1) visionary leadership, learning organization and innovative behavior have a direct and positive impact on performance, 2) visionary leadership, and learning organization have a direct and positive impact on innovative behavior and 3) visionary leadership have a direct and positive impact on learning organization. The conclusion of this research is to improve the performance of Functional Officer of Customs and Excise Inspectors at TanjungPriok Customs and Excise Main Service Office, it is necessary to increase the aspect of visionary leadership from Head of Main Service Office, learning organization at Main Service Office and innovative behavior at Functional Officers of Customs and Excise Inspectors.
Keywords : visionary leadership, learning organization, innovative behavior, and Performance.
STRATEGY OF PROMOTING LIBRARIANâ€™S PERFORMANCE IN CREATING USERâ€™S SATISFACTION IN NATIONAL LIBRARY OF INDONESIA
Authors: Masykuri Ahmad 
Published: October 2019

The objective of this research is to determine the influence of the corporate culture, employee empowerment, librarianship training and work ethics towards employee performance (case study in National Library of Indonesia) Jl. Salemba Raya 28 A Jakarta, UPT Bung Karno Library in Blitar, and UPT Bung Hatta Library in Bukit Tinggi. The research approach is using quantitave method with path analysis. Sampling techniques is simple random sampling with a representative sample of 124 librarians. The data was collected through a Likert type structured questionaire toward variables. The next step is to test the validity by using the Pearson Product Moment test analysis and Realibility test by using Cronbach Alpha test and then the data was analyzed as requirement of statistic test; normality test error with Lilliefors, homogenity test and tests of significance and linearity of regression coefficients. The result such as: 1. Corporate culture, employee empowerment, librarianship training and work ethic has direct positive and significant effects towards performance. 2. Corporate culture and employee empowerment has direct positive and significant effects towards work ethic. 3. Employee empowerment has direct positive effects, but not significant to work ethics. Research implication showed the important of policy and chief regulatory about strengthen corporate culture, librarian empowerment equality and enhancement librarianship training.
Keywords: Performance, Corporate culture, employee empowerment, librarianship training, work ethic