bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac output‐guided hemodynamic therapy for adult living donor kidney transplantation in children under 20 kg: A pilot study
Authors: Voet Marieke , Nusmeier Anneliese , Lerou Jos , Luijten Josianne , Cornelissen Marlies , Lemson Joris 
Published: July 2019

AbstractBackgroundA living‐donor (adult) kidney transplantation in young children requires an increased cardiac output to maintain adequate perfusion of the relatively large kidney. To achieve this, protocols commonly advise liberal fluid administration guided by high target central venous pressure. Such therapy may lead to good renal outcomes, but the risk of tissue edema is substantial.AimsWe aimed to evaluate the safety and feasibility of the transpulmonary thermodilution technique to measure cardiac output in pediatric recipients. The second aim was to evaluate whether a cardiac output‐guided hemodynamic therapy algorithm could induce less liberal fluid administration, while preserving good renal results and achieving increased target cardiac output and blood pressure.MethodsIn twelve consecutive recipients, cardiac output was measured with transpulmonary thermodilution (PiCCO device, Pulsion). The algorithm steered administration of fluids, norepinephrine and dobutamine. Hemodynamic values were obtained before, during and after transplantation. Results are given as mean (SD) [minimum‐maximum].ResultsAge and weight of recipients was 3.2 (0.97) [1.6‐4.9] yr and 14.1 (2.4) [10.4‐18] kg, respectively. No complications related to cardiac output monitoring occurred. After transplantation, cardiac index increased with 31% (95% CI = 15%‐48%). Extravascular lung water and central venous pressure did not change. Fluids given decreased from 158 [124‐191] mL kg−1 in the first 2 patients to 80 (18) [44‐106] mL kg−1 in the last 10 patients. The latter amount was 23 mL kg−1 less (95% CI = 6‐40 mL kg−1) than in one recent study, but similar to that in another. After reperfusion, all patients received norepinephrine (maximum dose 0.45 (0.3) [0.1‐0.9] mcg kg−1 min−1). Patient and graft survivals were 100% with excellent kidney function at 6 months post‐transplantation.ConclusionTranspulmonary thermodilution‐cardiac output monitoring appeared to be safe and feasible. Using the cardiac output‐guided algorithm led to excellent renal results with a trend toward less fluids in favor of norepinephrine.
Social support and treatment adherence in patients with end‐stage renal disease: A systematic review
Authors: Sousa Helena , Ribeiro Oscar , Paúl Constança , Costa Elísio , Miranda Vasco , Ribeiro Fernando , Figueiredo Daniela 
Published: July 2019

AbstractSuccessful dialysis in end‐stage renal disease (ESRD) largely depends on the patients’ ability to adhere to several clinical requirements and life‐style changes. Social support has been consistently linked to better health outcomes in a number of chronic diseases. The current study presents a systematic review of the literature on the relationship between social support and treatment adherence in ESRD. The search was performed on Web of Science, PsycInfo, ScienceDirect, and Scopus from January 19 to May 15, 2019. Two hundred and twenty‐four records were identified. After quality assessment, 17 studies were included for qualitative synthesis. This review comprised a total of 2362 patients. Most patients were on hemodialysis (97.5%) for an average of 58.2 months. Results suggested an overall pattern of mixed findings regarding the association between social support and treatment adherence. Adherence to fluid restrictions was the type of adherence with more significant associations with social support (63%). Mixed results were found for adherence to dialysis sessions (50%) and to medication (50%). Associations between adherence to diet restrictions and social support were found in 44% of the included studies. No significant associations were found between social support and adherence to follow‐up consults. All of the included studies combining several types of adherence into an overall score found significant associations with social support. Findings suggested that it might be particularly beneficial to focus future research and clinical efforts toward social support from family, significant others, and health professionals, to improve patient's with ESRD treatment adherence.
Human errors in manual techniques for ABO/D grouping are associated with potentially lethal outcomes
Authors: Mistry H. , Poles D. , Watt A. , Bolton‐Maggs P. H. B. ,   on behalf of the SHOT Steering Group
Published: July 2019

SummaryAims/ObjectivesTo review if ABO/D grouping errors are more likely to occur with manual intervention compared to automation.BackgroundHuman errors in manual pre‐transfusion testing may result in ABO/D‐incompatible transfusions and catastrophic outcomes. Accurate ABO/D grouping is a critical part of pre‐transfusion testing.MethodsThis was a retrospective analysis of reports made to Serious Hazards of Transfusion (SHOT) between January 2004 and December 2016 where ABO/D grouping errors led to the transfusion of an incorrect blood component to review if errors are more likely to occur with manual intervention compared to automation.ResultsIn 148 of 158 (93%) ABO/D grouping errors, manual intervention took place. In the remaining 10, causes were not reported. No errors occurred with full automation. Interpretation errors occurred in 86 of 148 (58%) and 42 of 148 (28%) transcription errors, and in 20 of 148, wrong or no samples were selected. Of 148 errors, 21 (14%) resulted in ABO‐incompatible transfusion, with one death in 2004 due to an interpretation error in a manual ABO group. In 30 of 148 (20%), D‐positive red cells were given to D‐negative recipients, where three women of child‐bearing potential became sensitised and developed anti‐D. ABO grouping errors have reduced from 18 of 539 (3%) of total reports analysed in 2004 (3·3%) to 3 of 3091 (0·10%) in 2016.ConclusionsWhere manual testing cannot be avoided, results should be confirmed using automated techniques as soon as possible, and a back‐up process should be available 24/7. SHOT data confirm that manual interventions are prone to human error, especially in transcription and interpretation, and demonstrate a continuing need for appropriate serological knowledge and understanding by transfusion laboratory staff to underpin safety provided by automation and information technology (IT).
TEMPRANILLO is a direct repressor of the microRNA miR172
Authors: Aguilar‐Jaramillo Andrea E. , Marín‐González Esther , Matías‐Hernández Luis , Osnato Michela , Pelaz Soraya , Suárez‐López Paula 
Published: July 2019

SummaryIn the age‐dependent pathway, microRNA 156 (miR156) is essential for the correct timing of developmental transitions. miR156 negatively regulates several SPL genes, which promote the juvenile‐to‐adult and floral transitions in part through upregulation of miR172. The transcriptional repressors TEMPRANILLO1 (TEM1) and TEM2 delay flowering in Arabidopsis thaliana at least through direct repression of FLOWERING LOCUS T (FT) and gibberellin biosynthetic genes, and have also been reported to participate in the length of the juvenile phase. Levels of TEM mRNA and miR156 decrease gradually, allowing progression through developmental phases. Given these similarities, we hypothesized that TEMs and the miR156/SPL/miR172 module could act through a common genetic pathway. We analyzed the effect of TEMs on levels of miR156, SPL and miR172, tested binding of TEMs to these genes using chromatin immunoprecipitation and analyzed the genetic interaction between TEMs and miR172. We found that TEMs played a stronger role in the floral transition than in the juvenile‐to‐adult transition. TEM1 repressed MIR172A, MIR172B and MIR172C expressions and bound in vivo to at least MIR172C sequences. Genetic analyses indicated that TEMs affect the regulation of developmental timing through miR172.
Seismic stratigraphy of the Sabrina Coast shelf, East Antarctica: Early history of dynamic meltwater-rich glaciations
Authors: Montelli Aleksandr , Gulick Sean P.S. , Fernandez Rodrigo , Frederick Bruce C. , Shevenell Amelia E. , Leventer Amy , Blankenship Donald D. 
Published: July 2019

AbstractHigh-resolution seismic data from the Sabrina Coast continental shelf, East Antarctica, elucidate the Cenozoic evolution of the East Antarctic Ice Sheet. Detailed seismic stratigraphic and facies analysis reveal the Paleogene to earliest Pliocene glacial evolution of the Aurora Basin catchment, including at least 12 glacial expansions across the shelf indicated by erosional surfaces and chaotic acoustic character of strata. Differences in facies composition and seismic architecture reveal several periods of ice-free conditions succeeded by glacial expansions across the shelf. A deep (∼100 m), undulating erosional surface suggests the initial appearance of grounded ice on the shelf. Following the initial ice expansion, the region experienced an interval of open-marine to ice-distal conditions, marked by an up to 200-m-thick sequence of stratified sediments. At least three stacked erosional surfaces reveal major cross-shelf glacial expansions of regional glaciers characterized by deep (up to ∼120 m) channel systems associated with extensive subglacial meltwater. The seismic character of the sediments below the latest Miocene to earliest Pliocene regional unconformity indicates intervals of glacial retreat interrupted by advances of temperate, meltwater-rich glacial ice from the Aurora Basin catchment. Our results document the Paleogene to late Miocene glacial history of this climatically sensitive region of East Antarctica and provide an important paleoenvironmental context for future scientific drilling to constrain the regional climate and timing of Cenozoic glacial variability.
Freshwater input, upwelling, and the evolution of Caribbean coastal ecosystems during formation of the Isthmus of Panama
Authors: Grossman Ethan L. , Robbins John A. , Rachello-Dolmen Paola G. , Tao Kai , Saxena Divya , O’Dea Aaron 
Published: July 2019

Abstract
Caribbean biota underwent major ecological and evolutionary transformation in the Pliocene–Pleistocene, but a lack of detailed paleoenvironmental reconstruction prevents thorough resolution of cause and effect. We quantify levels of upwelling and freshwater input into Caribbean coastal shelf ecosystems over the last ∼6 m.y. with >3300 stable isotope measurements from 74 fossil serially sampled gastropods by normalizing δ18O values to open-ocean δ18O from planktonic foraminifera. We find that the influence of Pacific-like upwelling in the southwestern Caribbean was low after 4.25 Ma but coastal ecosystems were heavily influenced by seasonal freshening until ca. 2.5 Ma, after which time low-freshwater conditions were established. The origination of modern oligotrophic coastal conditions was therefore a result of oceanographic change causing declining upwelling, and declining nutrients from terrestrial sources. We speculate that a southward shift of the Intertropical Convergence Zone, associated with Northern Hemisphere glaciation, reduced rainfall and terrestrial nutrient input and contributed to biotic turnover in the southwestern Caribbean, including the proliferation of modern reef communities.
CONTINUOUS MOTION AND TIME-VARYING STIFFNESS ESTIMATION OF THE HUMAN ELBOW JOINT BASED ON SEMG
Authors: LI KEXIANG , LIU XUAN , ZHANG JIANHUA , ZHANG MINGLU , HOU ZIMIN 
Published: July 2019

The flexibility of body joints plays an important role in daily life, particularly when performing high-precision rapid pose switching. Importantly, understanding the characteristics of human joint movement is necessary for constructing robotic joints with the softness of humanoid joints. A novel method for estimating continuous motion and time-varying stiffness of the human elbow joint was proposed in the current study, which was based on surface electromyography (sEMG). We used the Hill-based muscle model (HMM) to establish a continuous motion estimation model (CMEM) of the elbow joint, and the genetic algorithm (GA) was used to optimize unknown parameters. Muscle short-range stiffness (SRS) was then used to characterize muscle stiffness, and a joint kinetic equation was used to express the relationship between skeletal muscle stiffness and elbow joint stiffness. Finally, we established a time-varying stiffness estimation model (TVSEM) of the elbow joint based on the CMEM. In addition, five subjects were tested to verify the performance of the CMEM and TVSEM. The total average root-mean-square errors (RMSEs) of the CMEM with the optimal trials were 0.19[Formula: see text]rad and 0.21[Formula: see text]rad and the repeated trials were 0.24[Formula: see text]rad and 0.25[Formula: see text]rad, with 1.25-kg and 2.5[Formula: see text]kg-loads, respectively. The values of elbow joint stiffness ranged from 0–40[Formula: see text]Nm/rad for different muscle activities, which were estimated by the TVSEM.
A Tractable Class of Binary VCSPs via M-Convex Intersection
Authors: Hirai Hiroshi , Iwamasa Yuni , Murota Kazuo , Živný Stanislav 
Published: July 2019

A binary VCSP is a general framework for the minimization problem of a function represented as the sum of unary and binary cost functions. An important line of VCSP research is to investigate what functions can be solved in polynomial time. Cooper and Živný classified the tractability of binary VCSP instances according to the concept of “triangle,” and showed that the only interesting tractable case is the one induced by the joint winner property (JWP). Recently, Iwamasa, Murota, and Živný made a link between VCSP and discrete convex analysis, showing that a function satisfying the JWP can be transformed into a function represented as the sum of two quadratic M-convex functions, which can be minimized in polynomial time via an M-convex intersection algorithm if the value oracle of each M-convex function is given.In this article, we give an algorithmic answer to a natural question: What binary finite-valued CSP instances can be represented as the sum of two quadratic M-convex functions and can be solved in polynomial time via an M-convex intersection algorithm? We solve this problem by devising a polynomial-time algorithm for obtaining a concrete form of the representation in the representable case. Our result presents a larger tractable class of binary finite-valued CSPs, which properly contains the JWP class.
Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Authors: Sun Haoyu , Liu Lianxin , Huang Qiang , Liu Huan , Huang Mei , Wang Jiabei , Wen Hao , Lin Renyong , Qu Kun , Li Kun , Wei Haiming , Xiao Weihua , Sun Rui , Tian Zhigang , Sun Cheng 
Published: July 2019

Abstract
The discovery of CD49a+ liver-resident natural killer (NK) cells in mice alters our view of NK cells and provides another opportunity to study NK cells. Although evidence has suggested roles for NK cells in liver diseases, whether and how CD49a+ NK cells contribute to liver diseases remain unclear. In this study, we observed that accumulation of CD49a+ tissue-resident NK cells in human hepatocellular carcinoma (HCC) was higher than in peritumoral tissues. We studied the exhausted and regulatory phenotypes of CD49a+ tissue-resident NK cells by analysis of protein and mRNA. The proportion of CD49a+ NK cells was positively correlated to the proportion of NK cells expressing inhibitory receptors. In addition, CD49a+ NK cells expressed more of checkpoint molecules PD-1, CD96, and TIGIT. Transcriptomic analysis implicated CD49a+ tissue-resident NK cells in the negative regulation of immune responses. Comparison of murine and human CD49a+ NK cells revealed their distinct characteristics and functions. Finally, accumulation of tissue-resident CD49a+ NK cells in liver tumor was correlated to deteriorating disease condition and poor prognosis. Our findings show that CD49a+ NK cells accumulate in liver tumor and suggest a role for CD49a+ NK cells in the negative regulation of immune responses and the development of HCC.
Non–Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients With Cancer and Atrial Fibrillation: A Systematic Review and Meta‐Analysis
Authors: Deng Yuqing , Tong Yifan , Deng Yuanyuan , Zou Le , Li Shunhui , Chen Hui 
Published: July 2019

Background

Several studies have investigated the effect of non–vitamin K antagonist oral anticoagulants (
NOAC
s) in atrial fibrillation (
AF
) patients with cancer, but the results remain controversial. Therefore, we conducted a meta‐analysis to compare the efficacy and safety of
NOAC
s versus warfarin in this population.

Methods and Results

We systematically searched the PubMed and Embase databases until February 16, 2019 for studies comparing the effect of
NOAC
s with warfarin in
AF
patients with cancer. Risk ratios (
RR
s) with 95%
CI
s were extracted and pooled by a random‐effects model. Five studies involving 8908
NOAC
s and 12 440 warfarin users were included. There were no significant associations between cancer status and risks of stroke or systemic embolism, major bleeding, or death in
AF
patients. Compared with warfarin,
NOAC
s were associated with decreased risks of stroke or systemic embolism (
RR
, 0.52; 95%
CI
, 0.28–0.99), venous thromboembolism (
RR
, 0.37, 95%
CI
, 0.22–0.63), and intracranial or gastrointestinal bleeding (
RR
, 0.65; 95%
CI
, 0.42–0.98) and with borderline significant reductions in ischemic stroke (
RR
, 0.63; 95%
CI
, 0.40–1.00) and major bleeding (
RR
, 0.73; 95%
CI
, 0.53–1.00). In addition, risks of efficacy and safety outcomes of
NOAC
s versus warfarin were similar between
AF
patients with and without cancer.

Conclusions

In patients with
AF
and cancer, compared with warfarin,
NOAC
s had lower or similar rates of thromboembolic and bleeding events and posed a reduced risk of venous thromboembolism.
Impact of Missionary Training on Intercultural Readiness
Authors: Lee Paul Sungro 
Published: July 2019

Abstract
Going as a missionary or sending a missionary without proper training is quite reckless, and one of the most critical components of missionary preparation is intercultural readiness. This research was conducted to study the means to enhance one’s intercultural readiness and to measure its four sub-domain components that are likely to enable such a meaningful preparation at pre-departure stage. A group of 45 missions trainees at the Evangelical Alliance for Preacher Training/Commission’s School of Mission in Seoul, Korea were split into two groups, and quasi-experimental research was made on these groups through pre-test and post-test design. The research carefully examined whether EAPTC’s Missionary Candidate Training program could be another option for training the missionary candidates for effective cross-cultural performance with greater longevity on their field experience.
Mamas on Mission: Retracing the Church through the Spiritual Life Writing of Single Female Evangelical Missionaries
Authors: Chevalier Laura 
Published: July 2019

Abstract
This article plumbs the spiritual life writing of two twentieth-century single female evangelical missionaries, Lillian Trasher and Dr. Helen Roseveare, for evidence of the church. It rests on concepts of feminine spirituality and the history of women and mission. The historical analysis traces the women’s lives from their early formation through their mission work and looks at six themes of the church on mission that emerged from their writing. It argues that they served as mamas of the church in their contexts by nurturing life through their acts of compassionate care. Their small but deliberate acts of sacrifice and service continue to pose missiological invitations and challenges to the church. Therefore, the article also builds an initial “mama theology” of the church on mission by examining where images in Isaiah and impulses in mission today intersect with the themes in the women’s writing.
Islamic Musical Forms and Local Identity in Post-Reform Indonesia
Authors: Lahpan Neneng Yanti Khozanatu 
Published: July 2019

Abstract
Through an analysis of local Sundanese music in distinct settings in village and urban contexts, this article observes and analyses different constructions of meaning around Sundanese Islamic music, as well as the role played by cultural activists and village audiences in those constructions. Based on fieldwork in Tasikmalaya, West Java, I explore the novel meanings given to village genres in urban contexts, and contrast that with the affective responses of village audiences. I find that musical meanings offer different processes of identity formation within particular social boundaries. Emergent Indonesian political developments shape these processes.
Travelling with the Idea of Taking Sides
Authors: Lücking Mirjam 
Published: July 2019

Abstract
Israel and Indonesia share no diplomatic relations, and considering Indonesia’s cordial bonds with the Palestinian Authority, Indonesian society is deemed to be critical of Israel. However, the ways in which Indonesians relate to ‘Others’ in Israel and Palestine are not monolithic. Indonesian perspectives on the Middle East are far more nuanced, as might be assumed from the largest Muslim society in the world, and the idea of ‘taking sides’ is challenged by encounters on the ground and by inter- and intra-religious rivalries. Contemporary pilgrimage tourism from Indonesia to Israel and the Palestinian Territories shows how Christian and Muslim Indonesians engage in conflictive identity politics through contrasting images of Israeli and Palestinian Others. Indonesian pilgrims’ viewpoints on these Others and on the Israel–Palestine conflict mirror the politicization and marketization of religious affiliation. This reveals peculiarities of the local engagement with global politics and the impact of travelling, which can inspire both the manifestation of enemy images and the blurring of identity markers.
Three Eras of Indonesian Arts Diplomacy
Authors: Cohen Matthew Isaac 
Published: July 2019

Abstract
Sukarno took a personal interest in using the arts for presenting Indonesia in a positive light. He oversaw cultural missions abroad and produced ‘cultural events’ that showed off his grace and charisma on the dance floor to overseas guests. While Soeharto showed little interest in the arts, new modes of arts diplomacy flourished during the New Order—scholarships for foreigners to study arts, artists in residence at Indonesian embassies, large-scale festivals aiming to facilitate artistic exchange and encourage foreign investments, to name but a few. In Indonesia today, arts diplomacy is represented by its own sub-directorate in the Ministry of Education and Culture. Indonesia is promoting itself through collaborations between Indonesian governmental agencies and professional, international producing bodies, galleries, and festivals. Cultural Houses are being built in key cities abroad, along with a nationwide platform for international festivals, Indonesiana. ‘Indonesianists’, including foreign academics and students of the arts, are being recruited to promote Indonesia abroad.
Make-Up Therapy for Patients With Facial Nerve Palsy
Authors: Fujiwara Keishi , Furuta Yasushi , Aoki Wakae , Nakamaru Yuji , Morita Shinya , Hoshino Kimiko , Fukuda Atsushi , Homma Akihiro 
Published: July 2019

Objectives: To investigate the effectiveness of make-up therapy for patients with facial nerve palsy. Methods: Seven female patients with facial nerve palsy who received specialist make-up therapy were enrolled. The objective of the make-up therapy was to obtain a symmetrical facial appearance. Results: Overall score for the Facial Clinimetric Evaluation (FaCE) scale was significantly improved after make-up therapy. There was a tendency for symptoms of depression to be improved among patients after make-up therapy. Conclusion: Make-up therapy to improve the symmetry of facial appearance could afford a noninvasive and low-cost treatment for patients with facial nerve palsy, especially in terms of patient quality of life and psychological condition.