bluuebunny/crossref_metadata_2025_split huggingface dataset:
An in-app purchase framework for location-based AR games: the case of Pokémon Go
Authors: Hsiao Kuo-Lun , Lytras Miltiadis D. , Chen Chia-Chen 
Published: June 2019

Purpose
Although location-based augmented reality (AR) games are popular in recent years, the motivation of in-app purchases still needs further investigation. The purpose of this paper is to investigate the antecedents of the intention to make a purchase in location-based AR games.

Design/methodology/approach
This research develops a conceptual model and hypotheses based on the theory of perceived values and satisfaction to investigate the antecedents. An online questionnaire was developed and distributed on popular websites to collect data, and 662 usable responses were collected from the players of Pokémon Go in Taiwan.

Findings
In total, 22 hypotheses were validated by using partial least squares techniques. Among the antecedents of in-app purchases intention in the model, the perceived value and satisfaction were found to have strong direct effects. The antecedents of the perceived value (flow, design aesthetic, social self-expression and good price) have direct influences on the perceived value of all players. Design aesthetic, reward and the perceived value were found to have a direct impact on all players’ satisfaction. Moreover, the differences between paying users and non-paying users were discussed and verified.

Originality/value
The model demonstrated relatively good explanatory power for purchase intention in the context of location-based AR game. The proposed model can provide insights to location-based AR game developers to design their games and marketing strategies.
Research of data mining and web technology in university discipline construction decision support system based on MVC model
Authors: Huang Zhaokun , Liang Yufang 
Published: June 2019

PurposeTaking the discipline construction in colleges and universities as the application background, based on the research on data mining technology and decision support system technology, the data generated by university management information system are effectively utilized. The paper aims to discuss these issues.Design/methodology/approachBased on the Beijing Key Discipline Information Platform as the data source, the decision tree algorithm of data mining is studied. On the basis of decision tree C4.5, the Bayesian theory is applied to the post-pruning operation of the decision tree.FindingsA decision tree post-pruning algorithm based on the Bayesian theory is studied and put forward in order to simplify the decision tree, which improves the generalization ability of the whole algorithm. Finally, the algorithm is used to build the prediction model of key disciplines. Combined with the decision support system architecture, data warehouse and the data mining algorithm constructed by university discipline, based on J2EE standard enterprise system specification, MVC model is applied. Moreover, a prototype system of decision support system for discipline construction in colleges and universities with browser/server (B/S) structure is completed and implemented.Originality/valueA decision tree post-pruning algorithm based on the Bayesian theory is studied and put forward in order to simplify the decision tree, which improves the generalization ability of the whole algorithm. Finally, the algorithm is used to build the prediction model of key disciplines. Combined with the decision support system architecture, data warehouse and the data mining algorithm constructed by university discipline, based on J2EE standard enterprise system specification, MVC model is applied. Moreover, a prototype system of decision support system for discipline construction in colleges and universities with B/S structure is completed and implemented.
From stock selection to multi-asset investment management
Authors: Ascioglu Asli , Maloney Kevin John 
Published: June 2019

Purpose
The purpose of this paper is to trace the evolution of the Archway Investment Fund (AIF) at Bryant University from its founding in 2005 as a portfolio focused exclusively on US equities to a multi-asset program that incorporates US equities, non-US equities, equity ETFs, REITs, individual bonds, fixed income ETFs and options. It also describes the explicit introduction of environmental, social and governance (ESG) considerations into the investment process.

Design/methodology/approach
The paper follows a case study approach.

Findings
The paper describes the programmatic changes that accompanied this evolution in these areas: finance department curriculum innovations; the investment guidelines and constraints that govern the AIF; the investment process utilized; the oversight and governance process; and the reporting, presentation, and publicity initiatives that keep critical constituencies (university administration, faculty, alumni and students) informed and engaged in this program to sustain its success.

Originality/value
The vast majority of student-managed funds are equity funds focused on individual stock selection. The AIF is a multi-asset fund with separate equity and fixed income sub-portfolios that explicitly incorporates ESG factors into the security selection process.
Interactive trilateral foreign exchange exposure: insights from scenario analysis
Authors: O’Brien Thomas 
Published: June 2019

Purpose
The purpose of this paper is to present scenarios of interactive trilateral foreign exchange (FX) exposure, where a company’s exposures to two foreign currencies depend on those currencies’ FX rate with each other.

Design/methodology/approach
A pro forma analysis of three-way FX rate changes illustrates interactive trilateral FX exposure and generates observations for a multivariate regression estimation of FX exposure coefficients.

Findings
The multivariate regression estimates of FX exposure provide the basis for a useful financial hedging strategy for interactive trilateral FX exposure. Some of the FX exposure estimates have surprising signs and magnitudes.

Research limitations/implications
Scenario analysis does not result in a general theory of interactive FX exposure, but the study’s diverse and rich scenarios may provide helpful insights to theoretical and empirical researchers.

Practical implications
The scenarios relate to many common real-world situations and thus may help managers and educators better understand how to manage FX exposure.

Originality/value
The topic of interactive FX exposure is under-researched and under-covered in contemporary textbooks or the applied finance literature.
Exploring the relationship between reverse logistics and sustainability performance
Authors: Banihashemi Taknaz Alsadat , Fei Jiangang , Chen Peggy Shu-Ling 
Published: June 2019

PurposeThe implementation of reverse logistics (RL) as a strategic decision has gained significant attention amongst organisations due to its benefits to sustainable development. The purpose of this paper is to provide a comprehensive review of the literature to evaluate the performance of the RL process based on the three dimensions of sustainability including environmental, economic and social aspects.Design/methodology/approachContent analysis was adopted to collect and analyse the information.FindingsThe findings of this research show that most of the studies have focused on the performance evaluation of RL by considering the factors associated with economic and environmental performance. The social aspect of RL has been overlooked and requires investigation due to its contribution to positive social outcomes. In addition, no research has been conducted to assess the impact of each of the disposition options on the triple-bottom-line sustainability performance in one study.Originality/valueAlthough RL can make a significant contribution to improving the sustainability performance of firms, little research has been undertaken on exploring the relationship between RL and sustainability performance. This paper provides practitioners, academics and researchers a broad and complete view of the relationship between RL and sustainability performance with suggestion for future research.
Voluntary hedging disclosure and corporate governance
Authors: Hoelscher Seth A. 
Published: June 2019

Purpose
This paper aims to investigate the implications of governance quality on a firm’s information environment in the context of voluntary changes in hedging disclosures made by oil and gas companies.

Design/methodology/approach
The research utilizes a Factiva-guided search to hand-collect public disclosures related to changes in hedging policies along with the hand collection of financial derivatives positions and operational hedging contracts data using 10-K filings. The paper addresses self-selection bias, which typically plagues voluntary disclosure studies, by implementing a Heckman (1979) two-step model to estimate the decision process, make changes in their hedge program and, conditional on making changes to their hedging activities, provide disclosure.

Findings
Oil and gas firms with relatively poor governance are more likely to voluntarily disclose hedging changes and do so more frequently (substitution hypothesis). There is evidence that poorly governed firms in the presence of large shareholders (i.e. high institutional ownership) are more likely to provide transparency of hedging policy changes.

Originality/value
This is the first study to combine hand-collected changes in hedging voluntary disclosures and hand-collected derivative position data to investigate the interaction of corporate governance and voluntary disclosure. The sample allows for analysis between three sub-samples: companies that do not make changes in hedging and do not hedge, firms that make changes in their hedging policies but do not disclose the changes during a given year and companies that change their hedging activities and provide voluntary disclosure. This unique setting helps to alleviate concerns of self-selection bias associated with voluntary disclosure.
Estimating local administrators’ participation in planning: case of “Egypt vision 2030”
Authors: Moghaieb Heba Saleh 
Published: June 2019

Purpose
This paper aims to address to what extent local administration is involved in national planning focusing on drafting and reviewing processes of “Egypt Vision 2030”.

Design/methodology/approach
The paper plan to use focus group discussions and descriptive-analytical approach with representatives of local administration in three governorates.

Findings
Importance of local participation is not any more a question; however, participation concept and methodology are what matters. Participatory approach is not complex-free. It is crucial to consider conflicts of interest groups, ideologies, and political trends, communities’ high expectations, particularly of those who were marginalized and deprived for long time. Definitions should not be unified on national, regional and local levels. Each community needs to agree on its own definitions, needs, dreams and paths toward development. Accordingly, the role of the planner is to expand choices and opportunities for each citizen. Participation in planning for the future must include the coming generation who are opting to live this tomorrow. That requires institutionalization of youth participation in the decision-making processes.

Research limitations/implications
It was difficult to ensure meeting adequate sample; however, the author does believe that the participated sample represents the case.

Practical implications
The impact of public participation in planning on enhancing the planning processes and strategic planning outcomes and implementation is not a matter of questioning anymore, although governments do not pay due attention.

Social implications
Public participation in planning processes named participative planning is crucial for achieving development, social justice, economic development and public trust in governments.

Originality/value
The paper depends on focus-group discussions that were conducted by the author. Analysis and discussions reflect the author’s academic and practical experiences.
MicroRNA‐33a‐5p suppresses colorectal cancer cell growth by inhibiting MTHFD2
Authors: Yan Yan , Zhang Ding , Lei Ting , Zhao Chang'an , Han Jia , Cui Jiarui , Wang Yili 
Published: June 2019

AbstractColorectal cancer (CRC) is one of the most common malignancies with high levels of invasiveness, drug resistance and mortality, but the internal mechanisms of CRC are largely unknown. MicroRNAs (miRs) have been reported to be involved in the development of CRC, and numerous studies have demonstrated that the abnormal expression of miR‐33a‐5p might be associated with CRC. However, the function and downstream mechanism of miR‐33a‐5p in colorectal cancer (CRC) remains unclear. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme involved in folic acid metabolism, interestingly was confirmed to be one of the target genes of miR‐33a‐5p in the present study. We first confirmed that miR‐33a‐5p in CRC tissues and cell lines were downregulated (P < 0.05), and that the proliferation, clone formation capacities, G1/S progression, and migration capacities of the two CRC cell lines HCT116 cells and HT29 were suppressed by miR‐33a‐5p overexpression in vitro (P < 0.05). Ctrl HCT116 and miR‐33a‐5p‐overexpressing HCT116 were injected into nude mice. In vivo tumour formation was significantly suppressed by miR‐33a‐5p overexpression (P < 0.05) as well as the proliferation marker Ki67 (P < 0.05). Additionally, MTHFD2 protein expression was significantly enhanced in CRC tissues. From bioinformatics predictions and a luciferase report analysis, MTHFD2 was confirmed to be one of the target genes of miR‐33a‐5p. In contrast to the role of miR‐33a‐5p overexpression, MTHFD2 overexpression promoted the proliferation and migration of HCT116 and HT29 cells (P < 0.05), which confirmed that MTHFD2 was a functional target gene of miR‐33a‐5p. In conclusion, miR‐33a‐5p inhibits the growth and migration of CRC by targeting MTHFD2.
Inhibition of mitochondrial respiration by tigecycline selectively targets thyroid carcinoma and increases chemosensitivity
Authors: Wang Yuehua , Xie Fei , Chen Dejie , Wang Ling 
Published: June 2019

AbstractThe role of mitochondria in cancer and mitochondria‐targeted therapy has been gaining attention for its effectiveness and selectivity between cancer and normal cells. In line with this notion, our work demonstrates that inducing mitochondrial dysfunction by tigecycline, a FDA‐approved antibiotic, selectively targets thyroid cancer and enhances chemosensitivity. We found that tigecycline inhibited proliferation and induced apoptosis in a panel of thyroid cancer cell lines. Consistently, tigecycline inhibited thyroid cancer growth in mice without causing significant toxicity. The combination of tigecycline with paclitaxel achieved greater efficacy than paclitaxel alone in vitro and in vivo. Mechanistically, tigecycline inhibited mitochondrial respiration and ATP reduction through decreasing mitochondrial membrane potential and inhibiting mitochondrial translation, leading to oxidative stress and damage. In contrast, tigecycline was ineffective in mitochondrial respiration‐deficient cells, confirming that tigecycline acts on thyroid cancer via inhibiting mitochondrial respiration. Interestingly, although tigecycline inhibited mitochondrial respiration in both thyroid cancer and normal thyroid cells in a similar manner, tigecycline was more effective in thyroid cancer than normal thyroid cells, suggesting that thyroid cancer cells are more dependent on mitochondrial functions than normal thyroid cells. This was supported by our observations that thyroid cancer cells had higher level of mitochondrial biogenesis compared to normal thyroid cells. Our work is the first to demonstrate that the combination of chemotherapy with tigecycline is a potential sensitizing strategy for thyroid cancer treatment. Our findings also highlight the higher dependence of thyroid cancer cells on mitochondrial functions than normal thyroid cells.
Embedded Enclaves: Cultural Mimicry and Urban Social Exclusion in Iran
Authors: Hashemi Manata 
Published: June 2019

AbstractThis article argues that symbolic boundaries and their spatial manifestation into embedded enclaves have become new forms of urban social exclusion. Based on participant observation and interviews among lower‐ and middle‐/upper‐class residents in the city of Sari, Iran, the article analyzes how the poor's physical circulations in the city and their performances of class and status have led to an elite backlash, as the latter find more refined markers of social separation in an effort to bolster their own exclusivity. Social distancing through the denigration of the poor and the construction of embedded enclaves brings to the fore the class tensions that are temporarily masked by the urban poor's spatial practices and cultural mimicry. As an advanced form of codified status inequality, embedded enclaves rely on the poor's citywide circulations and on increasing inter‐class interactions in order to communicate difference. Embedded—rather than cordoned off—in prominent areas of the city, such enclaves function as a reminder to the poor of all they cannot have. The upsurge of such establishments in the wake of Iran's shifting economic environment represents an attempt to shore up social position and restore the status quo.
Forty‐Three Fatalities Involving the Synthetic Cannabinoid, 5‐Fluoro‐ADB: Forensic Pathology and Toxicology Implications
Authors: Boland Diane M. , Reidy Lisa J. , Seither Joshua M. , Radtke Jay M. , Lew Emma O. 
Published: June 2019

AbstractForty‐three fatalities involving the potent synthetic cannabinoid, 5‐Fluoro‐ADB, are summarized. For each case, a description of the terminal event, autopsy findings, cause of death, qualitative identification of 5‐Fluoro‐ADB and its ester hydrolysis metabolite, 5‐Fluoro‐ADB metabolite 7, in urine, and the quantitative values obtained in the blood specimens are outlined. Central blood concentrations ranged from 0.010 to 2.2 ng/mL for 5‐Fluoro‐ADB and 2.0 to 166 ng/mL for 5‐Fluoro‐ADB metabolite 7. Peripheral blood concentrations ranged from 0.010 to 0.77 ng/mL and 2.0 to 110 ng/mL for 5‐Fluoro‐ADB and 5‐Fluoro‐ADB metabolite 7, respectively. The majority of cases resulted in central to peripheral blood concentration ratios greater than 1 for 5‐Fluoro‐ADB (58%) and 5‐Fluoro‐ADB metabolite 7 (71%) suggesting that postmortem redistribution occurs to some extent. Combining the increased cardiac weight and/or gastric volume and toxicology data identifying 5‐Fluoro‐ADB, it is hypothesized that abuse of this substance may precipitate a dysrhythmia and cause sudden death.
Expression fusion immunogen by live attenuated Escherichia coli against enterotoxins infection in mice
Authors: Feng Ni , Guan Weikun 
Published: June 2019

SummaryPrevious epidemiological studies have shown that enterotoxins from enterotoxigenic Escherichia coli (ETEC) appear to be the most important causes of neonatal piglet and porcine post‐weaning diarrhoea (PWD). Thus, it is necessary to develop an effective vaccine against ETEC infection. In the present study, the Kil cassette was inserted into the pseudogene yaiT by homologous recombination to create an attenuated E. coli double selection platform O142(yaiT‐Kil). After that, PRPL‐Kil was replaced with a fusion gene (LTA1‐STa13‐STb‐LTA2‐LTB‐STa13‐STb) to establish oral vaccines O142(yaiT::LTA1‐STa13‐STb‐LTA2‐LTB‐STa13‐STb) (ER‐T). Subsequently, BALB/c mice were orally immunized with ER‐T. Results showed that serum IgG and faecal sIgA responded against all ETEC enterotoxins and induced F41 antibody in BALB/c mice by orogastrically inoculation with recombinant E. coli ER‐T. Moreover, the determination of cellular immune response demonstrated that the stimulation index (SI) was significantly higher in immunized mice than in control mice, and a clear trend in the helper T‐cell (Th) response was Th2‐cell (IL‐4) exceed Th1‐cell (IFN‐γ).Our results indicated that recombinant E. coli ER‐T provides effective protection against ETEC infection.
Low levels of pannexin‐1 in Behçet’s syndrome
Authors: Şahin Ali , İlhan Abdullah , Derin Mehmet Emin , Doğan Halef Okan , Şahin Mehtap 
Published: June 2019

AbstractObjectiveBehçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects, to investigate their level in patients and their relationship with the clinical findings.MethodForty‐six patients who were under follow‐up for BS in the Sivas Cumhuriyet University Medical Faculty Department of Internal Diseases, Rheumatology Unit, between January 2017 and June 2017 and 44 healthy controls (HC) who did not have any rheumatic, systemic or metabolic diseases, were enrolled in this study.ResultsThe mean serum pannexin‐1 level was 6.36 (4.21‐527.2) pg/mL in the BS group and 255.8 (5.38‐2000) pg/mL in the HC group. Serum pannexin‐1 levels were statistically significantly lower in the BS group (P < 0.0001). The measured mean serum caspase‐3 level was 12.04 (11.25‐43.69) pg/mL in the group with BS and 12.1 (11.19‐484.3) pg/mL in the HC group (P = 0.143), mean serum caspase‐9 level was 22 (5.14‐29.33) pg/mL in the BS group and 22.01 (11.23‐850) pg/mL in the HC group (P = 0.593), mean serum caspase‐14 level was 6 (5.2‐8.21) pg/mL in the BS group and 6.15 (5.7‐353) pg/mL in the HC group (P = 0.053).ConclusionComparison of serum caspase‐3, caspase‐9 and caspase‐14 levels in subjects with BS and in the HC group did not reveal any statistically significant differences. On the other hand, serum pannexin‐1 levels were statistically significantly lower in the BS group.
Incidence of delayed venous thromboembolic events in patients undergoing abdominal and pelvic surgery for cancer: a systematic review and meta‐analysis
Authors: Serrano Pablo E. , Parpia Sameer , Valencia Marlie , Simunovic Marko , Bhandari Mohit , Levine Mark 
Published: June 2019

BackgroundIncidence of venous thromboembolism (VTE) following discharge for abdominal cancer surgery is uncertain.MethodsWe searched MEDLINE and Embase for studies evaluating the incidence of VTE at 3 months from surgery. Studies indicating use of post‐hospital VTE prophylaxis were excluded. Two independent reviewers performed study selection, data abstraction and risk of bias. Random‐effects model was used to estimate pooled incidence, and weights were estimated using inverse variance method. Statistical heterogeneity was explored via subgroup analysis.ResultsOf 4215 abstracts retrieved, 11 reported the incidence of VTE at 3 months. There were three randomized trials (n = 520), one prospective cohort study (n = 284) and seven retrospective cohort studies (n = 65 308). VTE incidence among prospective studies was 9.6% (95% confidence interval (CI) 2.9–16.4), while for retrospective studies was 2.2% (95% CI 1.4–3.0). Heterogeneity was high (I2 = 92% and 81%, respectively). The incidence of symptomatic VTE was 1.3% (95% CI 0.4–2.3) for prospective studies. VTE was diagnosed by screening venography in most of the prospective studies, whereas retrospective studies did not use a screening method. Subgroup analysis based on the type of organ surgery performed explained the heterogeneity.ConclusionsVTE incidence following abdominal cancer surgery varies greatly depending on the study type, with differences largely explained by the method of assessment of VTE. The fact that VTE incidence among retrospective studies was closer to the incidence of symptomatic events (non‐screen detected) in the prospective studies, suggests that the screened events were mostly asymptomatic and their clinical significance is unclear.