bluuebunny/crossref_metadata_2025_split huggingface dataset:
Herbal medicine (Zhengan Xifeng Decoction) for essential hypertension protocol for a systematic review and meta-analysis
Authors: Huang Yonglian , Chen Yanhong , Cai Hairong , Chen Dongjie , He Xiaoming , Li Zhixiong , Cai Xiaojing , Peng Xiaohong , Huang Yaxiu , Li Shaoping , Cao Qifeng , Wang Ping , Chen Bojun 
Published: February 2019

Abstract

Background:
Essential hypertension is one of the most common chronic diseases worldwide, as well as a leading risk factor for cardiocerebrovascular diseases. Zhengan Xifeng Decoction (ZGXFD) has been widely used to treat essential hypertension, but there is no systematic review by assessing efficacy and safety of ZGXFD on essential hypertension. Therefore, we aim to perform systematic review and meta-analysis to evaluate the efficacy and safety of ZGXFD in the treatment of essential hypertension.

Methods:
This systematic review and meta-analysis will be performed by means of electronic databases, including EMBASE, Cochrane Center Registration Controlled trials (Cochrane Library), Web of Science (WOS), World Health Organization International Clinical Trials Registry Platform, PubMed, China Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), and Wan-fang database. The electronic databases will be searched from their inception to October 2018. This systemic review will include only published English and Chinese articles randomized controlled trials (RTCs) of ZGXFD on essential hypertension. The primary outcome is Efficacy and blood pressure (BP), blood lipid and adverse reactions will be accepted as secondary outcomes. All statistical analyses will be conducted using RevMan V.5.3.5 software.

Results:
This systematic review and meta-analysis will provide high-quality evidence from several aspects, including for efficacy, blood pressure, blood lipid and adverse effects to evaluate the efficacy and safety of ZGXFD on EHTN.

Conclusion:
This systematic review will determine whether or not ZGXFD is an effective intervention for essential hypertension.
Comparison of clinical outcomes between intravascular optical coherence tomography-guided and angiography-guided stent implantation
Authors: Jiang Yu , He Li-Peng , Gong Ren , Lei Guang-Tao , Wu Yan-Qing 
Published: February 2019

Abstract

Objective:
This systematic review was designed to evaluate the overall efficacy of optical coherence tomography (OCT)-guided implantation versus angiography-guided for percutaneous coronary intervention.

Methods:
The following electronic databases, such as CENTRAL, PubMed, Cochrane, and EMBASE were searched for systematic reviews to investigate OCT-guided and angiography-guided implantation. We measured the following 7 parameters in each patient: stent thrombosis, cardiovascular death, myocardial infarction, major adverse cardiac events (MACE), target lesion revascularization (TLR), target vessel revascularization (TVR), all-cause death.

Results:
In all, 11 studies (6 RCTs and 5 observational studies) involving 4026 subjects were included, with 1903 receiving intravascular ultrasound-guided drug-eluting stent (DES) implantation and 2123 using angiography-guided DES implantation. With regard to MACE, MT, TLR, TVR, stent thrombosis and all-cause death, the group of OCT-guided implantation had no significant statistical association with remarkably improved clinical outcomes. However, its effect on cardiovascular death has a significant statistical difference in angiography-guided implantation group.

Conclusion:
In the present pool analysis, OCT-guided DES implantation showed a tendency toward improved clinical outcomes compared to angiography-guided implantation. More eligible randomized clinical trials are warranted to verify the findings and to determine the beneficial effect of OCT-guidance for patients.
In situ revascularization of bilateral complicated giant renal artery aneurysms
Authors: Chen Xiyang , Zhao Jichun , Huang Bin , Yuan Ding , Yang Yi 
Published: February 2019

Abstract

Rationale:
Renal artery aneurysm (RAA) is a rare entity, bilateral multiple RAAs near hilum with a maximum diameter of 7 cm are even rare and bring a great challenge to surgeons. As the technique of vessel reconstruction is quite difficult for the RAAs near hilum, some surgeons choose to resect the involved kidney. We reported a young female patient with the threatened rupture symptoms for further treatment. The details of revascularization methods and procedure design were discussed in the report.

Patient concerns:
A young female patient complained with lumbar and abdominal pain for 1 month. Computed tomography angiography showed bilateral RAAs with the maximum diameter of 6 and 7 cm on the left and right side separately. For the right RAA, apart from a giant aneurysm, there was another small aneurysm with a diameter of 3 cm located on the inferior polar right renal artery. There was a mild tenderness on the left lumbar and lower abdomen, no rebound tenderness was detected.

Diagnosis:
According to the image feature and symptoms, the diagnosis for this patient was bilateral giant RAAs with threatened ruptured.

Interventions:
Dissection of the bilateral giant RAA and in situ revascularization of renal arteries with prosthetic graft was performed.

Outcomes:
The follow-up results showed the satisfactory patency of prosthetic graft and obvious improvement of renal function.

Lessons:
This complicated bilateral giant RAAs was successfully revascularized through in situ renal artery repair with a very difficult procedure process. For the RAA near hilum, vessel reconstruction no matter through in situ or ex vivo are both difficult for surgeons. This extremely rare and difficult case could bring more confidence to surgeons who meet such complicated bilateral RAAs for choosing the vessel reconstruction rather than kidney resection.
MicroRNAs in sputum specimen as noninvasive biomarkers for the diagnosis of nonsmall cell lung cancer
Authors: Zhang Xiaoyun , Wang Qian , Zhang Shijie 
Published: February 2019

Abstract

Background:
Nonsmall cell lung cancer (NSCLC) is a serious leading cause of death worldwide. Recently, multiple researches have identified that microRNA (miRNA) in sputum could be a useful tool for NSCLC diagnosis. The objective of this study was to assess whether aberrant miRNA expression could be regarded as a useful biomarker in sputum specimen for the diagnosis of NSCLC.

Methods:
Eligible studies were searched in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases up to June 2018. We calculated the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) to investigate the diagnostic value of miRNA in sputum for NSCLC. MetaDisc1.4 and STATA12.0 were used to analyze the retrieved data.

Results:
Finally, a total of 14 articles were included in this meta-analysis involving 1009 NSCLC patients and 1006 controls. The results were as followed: the pooled sensitivity, specificity, PLR, NLR, DOR, were 0.75 (95%CI:0.72–0.78), 0.88 (95%CI:0.86–0.90), 5.70 (95%CI:4.82–6.75), 0.30 (95%CI:0.26–0.34), 22.43 (95%CI:17.48–28.79), respectively. The AUC of overall summary receiver operator characteristic curve (SROC) was 0.8917.

Conclusion:
Our comprehensive analysis indicated that miRNAs in sputum specimen may be noninvasive diagnostic biomarkers for NSCLC. However, much more studies should be conducted before clinical application.
Cerebral venous sinus thrombosis due to hyperhomocysteinemia with cystathionine-β-synthase (CBS) gene mutation
Authors: Shang Ke , Li Hui , Luo Xiang 
Published: February 2019

Abstract

Rationale:
Risk factors of cerebral venous sinus thrombosis (CVST) are usually divided into acquired risks (e.g., trauma and pregnancy) and genetic risks (inherited thrombophilia). It is essential but not easy to identify the exact one for each patient.

Patient concerns:
A 14-year-old male patient was admitted in our hospital because of progressively exacerbated severe headache and vomiting for 3 days, accompanied by transient weakness once in his right leg.

Diagnosis:
CVST due to hyperhomocysteinemia with cystathionine-β-synthase (CBS) gene mutation.

Interventions:
Persistent oral anticoagulant therapy.

Outcomes:
Follow-ups at 4 months and 1 year showed that the patient's symptoms alleviated and did not recur, accompanied with improved MRV image; however, the cranial MRV image did not display as a completely normal one.

Lessons:
We recommend that in case of thrombophilic state, serum homocysteine (Hcy), folic acid, and vitamin B12 levels should be routinely screened; when serum Hcy level is extremely high, congenital diseases caused by gene mutations should be considered. We firstly discovered a new mutation of CBS c.949A>G which had not been reported before.
Diffuse large B-cell lymphoma of the central nervous system presenting as “lymphomatosis cerebri” and dementia in elderly man
Authors: Kerbauy Mariana Nassif , Pasqualin Denise da Cunha , Smid Jerusa , Iquizli Rogerio , Kerbauy Lucila Nassif , Nitrini Ricardo , Ribas Guilherme Carvalhal , Neder Luciano , Hamerschlak Nelson 
Published: February 2019

Abstract

Rationale:

Lymphomatosis cerebri is a rare form of PCNSL, characterized by diffuse infiltration of lymphoma cells in cerebral parenchyma, without mass-formation and mild or no contrast enhancement on magnetic resonance (MR) imaging. There are less than 50 cases described in the literature under the term Lymphomatosis cerebri.

Patient concerns:
A 74-year-old man presented to our service with progressive dementia for 12 months and accelerated cognitive decline within the last two months. Brain magnetic resonance imaging showed areas of hyperintensity involving predominantly the white matter of frontal lobes and knee of the corpus callosum, along with areas of blood-brain barrier disruption and areas of restricted diffusion. Stereotaxy brain surgery was indicated into contrasting areas and histologically there was heterogeneous foci of discreet infiltration of rare medium-large lymphoid cells intermingled with inflammatory cells and these atypical lymphoid cells were placed on breakdown neuropil and did not form tumor mass or sheets of cells, but occasionally displayed perivascular distribution. Immunohistochemically, these atypical lymphoid cells expressed CD20, Bcl2, Bcl6 and, heterogeneously, IRF4/MUM1.

Diagnosis:
The diagnosis of a primary CNS diffuse large B-cell lymphoma manifested as lymphomatosis cerebri was performed.

Interventions:
The treatment of choice was: temozolomide 100 mg/m2 (D1 to D5), methotrexate 3 g/m2 (D1, D10, and D20) and rituximab 375 mg/m2.

Outcomes:
The patient evolved with progressive neurological deterioration, regardless of the improvement on neuroimaging.

Lessons:
We described the diagnostic dilemma we faced with an elderly man with rapid cognitive impairment and a myriad of differential diagnoses, diagnosed with primary CNS diffuse large B-cell lymphoma with a lymphomatosis cerebri-like pattern.
Comparison the cost-efficacy of furazolidone-based versus clarithromycin-based quadruple therapy in initial treatment of Helicobacter pylori infection in a variable clarithromycin drug-resistant region, a single-center, prospective, randomized, open-label study
Authors: Yi Dong-Min , Yang Tao-Tao , Chao Shuai-Heng , Li Ya-Xin , Zhou Ying-Lei , Zhang Hai-Hui , Lan Ling , Zhang Yu-Wei , Wang Xue-Mei , Zhang Yan-Rui , Li Jian , Ding Song-Ze 
Published: February 2019

Abstract

Helicobacter pylori (Hp) drug resistant rate to clarithromycin (CLA) has increased to 20% to 50%, which cause concerns regarding its effectiveness in eradicating Hp, we aim to evaluate the cost-effectiveness of CLA-based versus furazolidone (FZD)-based quadruple therapy, and assess factors that affect anti-Hp efficacy.
One hundred eighty-five patients were enrolled in this single-center, prospective, randomized, open-label study. In FZD group, 92 patients were treated with FZD plus esomeprazole, bismuth potassium citrate, and amoxicillin for 14 days. In CLA group, 93 patients were treated with the same regimen except FZD was replaced by CLA. Patients were tested 4 weeks post-treatment to confirm eradication.
Of the 185 enrolled patients, 180 completed the study. On intention-to-treat analysis, Hp eradication rates in FZD and CLA groups were 90.22% and 86.02% (P = .378); in per-protocol analysis, their eradication rates were 93.26% and 87.91%, respectively (P = .220). Overall incidence of total side effects in FZD and CLA groups was 19.57% and 13.98%, and their severe side effects were 3.26% and 2.15%, respectively (P > .05). Cost-effectiveness ratios of FZD and CLA groups were 0.75 and 1.02, and incremental cost-effectiveness ratio of FZD group over CLA group was −3.62. Eradication failures were not associated with factors including gender, age, body mass index, smoking, alcohol consumption, educational level, and urban–rural distribution in this observation (P > .05).
Despite increasing drug resistance to CLA, Hp eradication rates in FZD and CLA groups have no significant difference at present; as FZD-based quadruple therapy is more cost-effective, we recommend this regimen be a first-line choice for Hp eradication.
Imaging findings of intraductal tubulopapillary neoplasm (ITPN) of the pancreas
Authors: Zhang Jingjing , Ren Shuai , Wang Jianhua , Ye Dandan , Zhang Huifeng , Qiu Wenli , Wang Zhongqiu 
Published: February 2019

Abstract

Rationale:
Intraductal tubulopapillary neoplasm (ITPN) is a rare type of pancreatic epithelial neoplasm. We report 2 cases of ITPN and detail the imaging findings.

Patient concerns:
The 1st case was a 36-year-old woman who complained of jaundice, yellow urine and diarrhea. She accepted ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) examination before surgery, which all revealed a mass in the pancreatic head. The 2nd case was a 62-year-old woman who was admitted to our hospital for the treatment of a pancreatic tumor. The MRI showed a mass filled the mian pancreatic duct in the head and neck.

Diagnosis:
The ITPN is an intraductal, grossly visible, tubule-forming epithelial neoplasm with high-grade dysplasia and ductal differentiation without overt mucin production.

Interventions:
The 1st patient received percutaneous transhepatic cholangial drainage procedure, endoscopic ultrasound guided fine needle aspiration, pancreatoduodenectomy, cholecystectomy, and lymphadenectomy successively. The 2nd patient received pancreaticoduodenectomy, cholecystectomy, and partial gastrectomy.

Outcomes:
Two months after surgery, the follow-up MRI revealed hepatic metastasis of the 1st patient. She is still alive now. The 2nd patient was lost to follow-up.

Lessons:
The ITPN is a rare pancreatic neoplasm and its clinical symptoms are atypical. It is difficult to make accurate diagnosis of ITPN before surgery even though various imaging modalities are used in combination. When a solid mass growing in the lumen of the pancreatic duct, ITPN should be taken into consideration.
Prevalence of bullying and perceived happiness in adolescents with learning disability, intellectual disability, ADHD, and autism spectrum disorder
Authors: Lung For-Wey , Shu Bih-Ching , Chiang Tung-Liang , Lin Shio-Jean 
Published: February 2019

AbstractChildren with learning disability (LD), intellectual disability (ID), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD) reported higher risk of being bullied compared to their peers. Controlling for the co-morbidity of different diagnosis is important in investigating the frequency of bullying. Therefore, this study aimed to investigate the pathway relationship of adolescents’ psychiatric diagnoses, including LD, ID, ADHD, ASD, with being bullied, their self-perceived psychological well-being (PWB) and social adaptation status (SAS) in 12-years-olds.The Taiwan Birth Cohort Pilot Study dataset (N = 1561) was used. The Chinese Oxford Happiness Questionnaire was used to measure PWB and SAS.Adolescent-reported rate of bullying was 25.4%, while only 2.8% of the parents reported knowing their child had been bullied. Boys reported higher rate of being bullied than girls. Adolescents with ADHD were not at higher risk of being bullied compared to their peers, nevertheless, they perceived lower level of SAS. Adolescents diagnosed with ID and ASD reported 63% rate of bullying and those who have been bullied perceived lower level of happiness.Adolescents with ADHD reported lower level of SAS, for disruption of harmony is even less acceptable in the Asian culture. Adolescents with ID and ASD reported higher rate of bullying than their peers and perceived lower level of happiness. A gap was found between parent and adolescent-reported rate of bullying. Encouraging adolescents to seek adult protection and support to reduce the effect of bullying on the perceived level of happiness is important.
HSV Hepatitis in Pregnancy: A Review of the Literature
Authors: McCormack Ashley Lane , Rabie Nader , Whittemore Brianna , Murphy Trevor , Sitler Collin , Magann Everett 
Published: February 2019

Importance
Herpes simplex virus (HSV) hepatitis is a rare condition with a high mortality rate. Immunocompromised individuals, including pregnant women, are the most susceptible. When primary infection occurs during pregnancy, risk for disseminated HSV is greatly increased. Disseminated HSV can manifest in the form of HSV hepatitis.

Objective
We aim to review the literature and summarize what is known about HSV hepatitis in pregnancy to aid in the diagnosis and treatment of this condition.

Evidence Acquisition
A literature search of PubMed and Web of Science was performed. A total of 237 citations were found. All citations were independently reviewed. Thirty-eight full-text articles were identified and included in this review. Additional data from 1 unpublished case from our institution was included.

Results
Fifty-six cases were included with average gestational age at diagnosis of 30 weeks. Patients presented with a wide variety of gastrointestinal, respiratory, neurologic, and urogenital symptoms. The most common examination findings were fever and abdominal tenderness. Only 18.2% of patients had a vesicular rash. All patients had a transaminitis, and 85% had positive viral cultures. A multitude of treatments were used with the majority of favorable outcomes occurring after treatment with acyclovir.

Conclusions and Relevance
Although HSV hepatitis is rare, it carries a mortality rate of up to 39% for mothers and neonates. Therefore, it is crucial that HSV hepatitis be included on the differential diagnosis when a patient presents with fever and transaminitis. When HSV hepatitis is suspected, empiric therapy with acyclovir can be initiated with no additional risk to the fetus.

Target Audience
Obstetricians and gynecologists, family physicians.

Learning Objectives
After completing this activity, the participant should be better able to (1) develop a reasonable differential diagnosis for hepatitis in pregnancy, including HSV hepatitis; (2) differentiate these etiologies based on common presentations, physical findings, and laboratory values; (3) value the usage of empiric acyclovir therapy in pregnancy-related hepatitis; and (4) counsel patients on safety measures to protect themselves and their unborn children from infection during pregnancy, including avoidance and vaccination.
Development of an Instrument to Assess Stroke Caregivers’ Readiness for the Transition Home
Authors: Camicia Michelle , Lutz Barbara J. , Harvath Theresa , Kim Katherine K. , Drake Christiana , Joseph Jill G. 
Published: February 2019

Abstract

Purpose
The study purpose was to develop a measure to assess stroke caregivers’ commitment and capacity to assume the caregiving role prior to discharge.

Design
Participants were caregivers of stroke survivors in an inpatient rehabilitation facility.

Methods
A sequential, multimethod approach, which included item generation from qualitative data, review of items by expert clinicians, cognitive interviews to determine response format (n = 22), and item clarity (n = 20), and an analysis of pilot data were utilized.

Findings
Cognitive interviewing provided information to improve item clarity.

Conclusion
This instrument development approach resulted in the Preparedness Assessment for the Transition Home After Stroke (PATH-s), a 26-item self-report instrument. The PATH-s represents the domains of the Model of Caregiver Readiness, upon which the instrument was developed.

Clinical Relevance
The PATH-s, once further validated, may guide healthcare providers in the development of tailored care plans to address identified gaps and better prepare caregivers for the transition home.
Long-term Results of the Side-to-side Isoperistaltic Strictureplasty in Crohn Disease
Authors: Michelassi Fabrizio , Mege Diane , Rubin Michele , Hurst Roger D. 
Published: February 2019

Objective:
Review the long-term outcomes of the side-to-side isoperistaltic strictureplasty (SSIS) and its effects on bowel preservation in Crohn disease (CD).

Summary Background Data:
The first SSIS was performed 25 years ago as an alternative to resection in the treatment of extensive fibrostenosing jejuno-ileal CD.

Methods:
Prospective study (January 1992–December 2016) of all patients with a SSIS performed by the authors. Long-term outcomes were evaluated radiographically, endoscopically, and histopathologically.

Results:
Sixty patients [14.4% of patients with jejuno-ileal bowel CD; 31 females; median age 36 (12–69) years] underwent 61 SSIS's for partial intestinal obstruction. Median length of preserved small bowel was 50 (20–148) cm. Associated strictureplasties and bowel resection were performed in 44% and 80%, respectively. Postoperative mortality occurred in 1 (PE on POD#8) and postoperative morbidity in 7 (12%). There were no sutureline dehiscences. SSIS resulted in resolution of preoperative symptoms in all. After a median follow-up of 11 years (range 1 mo–25 yrs), symptomatic recurrence was observed in 61%: 15 patients at the SSIS and 19 away from it (2 cases unclear location; 7 patients with >1 recurrence). Of 15 recurrences at SSIS's, 11 required surgical treatment (revision or strictureplasty in 6, SSIS removal in 5). Fifty-one patients (86%) maintain the original SSIS to date.

Conclusions:
SSIS is a safe, effective, and durable strictureplasty in patients with extensive fibrostenosing CD of the small bowel. Half the surgical recurrences on SSIS can be managed by subsequent revision or strictureplasty. The majority of patients maintain the original SSIS after a median follow-up of 11 years.