bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exosomes and Female Infertility
Authors: Sun Xiaoyan , Ma Xiaoling , Yang Xia , Zhang Xuehong 
Published: October 2019

Background:Exosomes are small Extracellular Vesicles (EVs) (40-100 nm) secreted by living cells and mediate the transmission of information between cells. The number and contents of exosomes are associated with diseases such as inflammatory diseases, cancer, metabolic diseases and what we are focusing in this passage-female infertility.Objective:This review focused on the role of exosomes in oocyte development, declined ovarian function, PCOS, uterine diseases, endometrial receptivity and fallopian tube dysfunction in the female.Methods:We conducted an extensive search for research articles involving relationships between exosomes and female infertility on the bibliographic database.Results:It has been reported that exosomes can act as a potential therapeutic device to carry cargoes to treat female infertility. However, the pathophysiological mechanisms of exosomes in female infertility have not been entirely elucidated. Further researches are needed to explore the etiology and provide evidence for potential clinical treatment.Conclusions:This review systematically summarized the role exosomes play in female infertility and its potential as drug delivery.
Simultaneous Determination of Five Irdoid Glycosides and Three Flavonoid Glycosides in Hedyotis Diffusa Wild by UPLC-UV with Ultrasound-Assisted Extraction
Authors: Huang Xuliang , Wu Youjia , Zhang Xiaoying , Chen Bing , Luo Hongbin , Lin Xinhua , Shi Peiying , Yao Hong 
Published: October 2019

Background:
Hedyotis diffusa is one of the most extensively used Chinese herbs for the
treatment of varieties of cancers in the folk of China. The ingredients of the preparation are still not very
clear and the quality control method of the herb medicine requires further improvement.
Introduction: In this paper, the quantitative methods for the quality control of H. diffusa were originally
developed by using UPLC-UV.

Methods:
Using the five irdoid glycosides and three flavonoid glycosides previously obtained from
H. diffusa as index components, referring to 10-Acetyl Scandoside Methyl Ester (ASME), Scandoside
(SD), Deacetyl Aspemloside (DA), Asperulosidic Acid (AA), Asperuloside (AD), Qurecetin-3-OSophoroside
(QS), Quercetin-3-O-[2-(6-O-E-Sinapoyl-β-D-Glucopyranosyl]-β-D-Glucopyranosyl (QESGG),
and Quercetin-3-O-[2-O-(6-O-E-Feruloyl)-β-D-Glucopyranosyl]-β-Glucopyanoside (QEFGG), the extraction
conditions, including solvents, durations, and cycles were optimized firstly. Subsequently, a
new UPLC-UV method was originally established to simultaneously determine the eight ingredients in
the Chinese herbal medicine.

Results:
The validated method exhibited good linearity (R2 > 0.999), repeatability (RSD < 3.01%),
intra- and inter-day precision (RSD <6.19%) and recoveries (96.31% to 104.22%) for the simultaneous
determination of the eight ingredients studied and had been used for the quality analysis of 6 batches of
H. diffusa sameples.

Conclusion:
The established UPLC-UV method could serve as a rapid and effective tool for quality
evaluation of the herbal medicine, H. diffusa.
Determination of Genotoxic alkyl p-toluene Sulfonates in Cabazitaxel using LC-MS Method
Authors: Mohan Bavireddi , Sharma Ramayanam Siva Kameswara , Kumar Devarakonda Ravi , Murali Mohan Rao Seshagiri Vijaya , Satya Venugopal Nutulapati Venkata 
Published: October 2019

Introduction:
A suitable LC-MS method for the quantitative determination of genotoxic
impurities such as alkyl p-toluene sulfonates in Cabazitaxel was developed. Alkyl p-toluene sulfonates
were estimated by LC-MS method using Waters Symmetry C18 (75×4.6 mm), 3.5 µ column.

Materials and Methods:
Column temperature was maintained 40 °C. Injection volume was 10 µL
and flow rate was set as 0.8 mL/min. Sampler temperature was maintained to 25 °C and run time
was set as 25 minutes. The mobile phase was a mixture of ammonium acetate buffer and acetonitrile
in 70:30(v/v) was used.

Results:
The method validation has been carried as per ICH guidelines. LOQ was found to be 2.66
µg/mL, 2.75 µg/mL and 2.55 µg/mL for MPTS, EPTS and IPPTS Alkyl p-Toluene Sulfonates
(APTS) respectively.

Conclusion:
The proposed Liquid chromatography-Mass spectroscopy method that can quantify
genotoxic APTS in Cabazitaxel at low-level concentration has been developed and validated as per
ICH guidelines. Hence, the proposed method was recommended for the assay of genotoxic impurities
of cabazitaxel in dosage forms in busy pharmaceutical laboratories.
Comparison of HIV Indicators after the Implementation of a New Model for TB and HIV Management in an Iranian Prison
Authors: Farhoudi Behnam , SeyedAlinaghi SeyedAhmad , Ataeinia Bahar , Hosseini Mostafa , Jafari Sirous , Alasvand Ramin , Tashakoriyan Mehrzad , Mohraz Minoo 
Published: October 2019

Objective:
A new national clinical guideline for the management of tuberculosis and
HIV in Iranian prisons was released in 2011. The aim of this study was to compare HIV indicators
in the case and control prisons after implementation of the new guideline.

Methods:
This report examines outcomes observed during the pilot phase of its implementation at
a case prison from October 2013 to June 2014 compared to a control prison that had not yet implemented
the guideline. The case prison included incarcerated individuals in the Great Tehran
Prison. A prison in Alborz province was considered as a control group. Pearson’s Chi-squared,
two-sample t-test, paired t-test and Kruskal-Wallis were used for the analysis.

Results:
The intervention significantly increased the total number of inmates tested for HIV and
of diagnoses of HIV-positive inmates in the case prison compared to the control prison (P<0.001).
Moreover, coverage of antiretroviral therapy was higher in the case prison compared to the control
prison (P=0.015).

Conclusion:
We recommend the implementation of this guideline in all Iranian prisons.
Exploring the Polymer Drawing of the Air Centrifugal Spinning
Authors: Liu Jia-Jia , Chen Ting , Wu Li-Li 
Published: October 2019

Background and Objective:
The air-flow field of the air centrifugal spinning is simulated
and measured. The simulated air velocities coincide well with the measured ones, confirming the correctness
of the air-flow field model.

Methods:
The polymer drawing in the air-flow field of the air centrifugal spinning is modeled and
simulated. Effects of the rotation speed and initial air velocity on the diameter and radius vector of the
threadline are investigated.

Results:
The air velocity is found to decrease with the increase of the distance away from the nozzle
exit. Simulation results show that both larger rotation speed and higher initial air velocity can reduce
the threadline diameter.

Conclusion:
The radius vector of the threadline increases rapidly with the increase of the initial air velocity,
which is helpful to reduce the threadline diameter.
Travel-time Prediction Using K-nearest Neighbor Method with Distance Metric of Correlation Coefficient
Authors: Jang Jinhwan 
Published: October 2019

Background:
Real-time Travel Time (TT) information has become an essential component of daily life in modern society. With reliable TT information, road users can increase their productivity by choosing less congested routes or adjusting their trip schedules. Drivers normally prefer departure time-based TT, but most agencies in Korea still provide arrival time-based TT with probe data from Dedicated Short-Range Communications (DSRC) scanners due to a lack of robust prediction techniques. Recently, interest has focused on the conventional k-nearest neighbor (k-NN) method that uses the Euclidean distance for real-time TT prediction. However, conventional k-NN still shows some deficiencies under certain conditions.

Methods:
This article identifies the cases where conventional k-NN has shortcomings and proposes an improved k-NN method that employs a correlation coefficient as a measure of distance and applies a regression equation to compensate for the difference between current and historical TT.

Results:
The superiority of the suggested method over conventional k-NN was verified using DSRC probe data gathered on a signalized suburban arterial in Korea, resulting in a decrease in TT prediction error of 3.7 percent points on average. Performance during transition periods where TTs are falling immediately after rising exhibited statistically significant differences by paired t-tests at a significance level of 0.05, yielding p-values of 0.03 and 0.003 for two-day data.

Conclusion:
The method presented in this study can enhance the accuracy of real-time TT information and consequently improve the productivity of road users.
Statistical Overview of Factors Influencing Traffic Accidents Severity On El-Brega Coastal Freeway in Libya
Authors: Omar Mohamed Buseif , Yusoff Nur Izzi , Mubaraki Muhammad , Rosyidi Sri Atmaja 
Published: October 2019

Background:
Globally, Road Traffic Accidents (RTAs) are one of the significant causes of fatality and injury. In Libya, RTAs have resulted in disabilities and were the third leading cause of death. However, there is a lack of information on RTAs and road safety in Libya.

Objective:
The present study aims to fill the knowledge gap by performing a statistical analysis to identify the factors associated with road accident severity in El-Brega Coastal Freeway.

Methods:
RTAs data extracted from police investigation reports in Ajdabiya Municipality for the period from 2001 to 2010. Then descriptive analysis and Binary logistic regression model (BLM) are applied to analyzing the data.

Results:
Descriptive analysis results showed that between 2001 and 2010, approximately 45% of RTAs in Ajdabiya Municipality occurred on El-Brega Coastal Freeway, and more than 1225 individuals lost their lives or sustained injuries in these RTAs. Furthermore, Sixty-two percent (n = 137) of those who died in accidents were from the 20–45 age group. BLM Results concluded that only eight predictors have statistical significant with accident injury severity. Five of them increase the likelihood of injury severity. A head-on collision is the prime influence factor to increase injury severity odds, followed by high-speed driving, Weekends, horizontal curves, and driver’s age. While accident injury tends to be less severe with the other predictors like rollover collision, rear-end collision, and accidents involving animals.

Conclusion:
Thus, implementing the use of seat-belt and speed control regulations, with activating ambulance services are the urgent countermeasures to enhance road safety.
The Psychiatric Drug Lithium Increases DNA Damage and Decreases Cell Survival in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines Expos ed to Ionizing Radiation
Authors: Rouhani Maryam , Ramshini Samira , Omidi Maryam 
Published: October 2019

Background:
Breast cancer is the most common cancer among women. Radiation therapy
is used for treating almost every stage of breast cancer. A strategy to reduce irradiation side effects and
to decrease the recurrence of cancer is concurrent use of radiation and radiosensitizers. We studied the
effect of the antimanic drug lithium on radiosensitivity of estrogen-receptor (ER)-positive MCF-7 and
ER-negative, invasive, and radioresistant MDA-MB-231 breast cancer cell lines.

Methods:
MCF-7 and MDA-MB-231 breast cancer cell lines were treated with 30 mM and 20 mM
concentrations of lithium chloride (LiCl), respectively. These concentrations were determined by
MTT viability assay. Growth curves were depicted and comet assay was performed for control and
LiCl-treated cells after exposure to X-ray. Total and phosphorylated inactive levels of glycogen
synthase kinase-3beta (GSK-3β) protein were determined by ELISA assay for control and treated
cells.

Results:
Treatment with LiCl decreased cell proliferation after exposure to X-ray as indicated by
growth curves of MCF-7 and MDA-MB-231 cell lines within six days following radiation. Such
treatment increased the amount of DNA damages represented by percent DNA in Tails of comets at
0, 1, 4, and even 24 hours after radiation in both studied cell lines. The amount of active GSK-3β
was increased in LiCl-treated cells in ER-positive and ER-negative breast cancer cell lines.

Conclusion:
Treatment with LiCl that increased the active GSK-3β protein, increased DNA damages
and decreased survival independent of estrogen receptor status in breast cancer cells exposed to
ionizing radiation.
A Report of Assessment Tools for Individuals with Dysarthria
Authors: Altaher Abeer Muneer , Chu Shin Ying , Kam Rahayu binti Mustaffa , Razak Rogayah A 
Published: October 2019

Introduction:The development of assessment tools for individuals with dysarthria has been reported in many clinical and empirical studies.Methodology:A literature review was based on online resources including Google Scholar, EBSCO, Medline, PubMed, and BIOMED Central articles and journals.Results and Conclusion:In this paper, we summarized the commonly used formal and informal assessment tools and explained the assessment procedure when managing clients with dysarthria. We aimed to share the current practice of speech-language pathologists together with the allied health service providers in the management of patients with dysarthria.
“Medical Clearance” of Psychiatric Patients in the Emergency Department
Authors: Santillanes Genevieve , Onigu-Otite Edore , Tucci Veronica , Moukaddam Nidal 
Published: October 2019

Background & goals:
The past few years have seen an increase in the number of
children and adolescents presenting to emergency departments with mental health complaints,
including, but not limited to, depression, suicidality, and substance use-related conditions.
This places many demands on the emergency physicians ranging from evaluating
medical stability (also known as medical clearance) to arranging for psychiatric are, be it inpatient
or outpatient. The goals of this article are to describe the current landscape of emergency
care for the pediatric patient presenting with mental health issues and to highlight gaps
in the current system.

Methods:
We review the literature on the epidemiology of mental health emergency visits
and guidelines for the medical clearance of pediatric and adolescent patients.

Results:
The needs of young patients with mental health difficulties exceed the resources
available in emergency care. Linkage to outpatient care is often inadequate and may be reinforcing
and perpetuating the current mental health crisis witnessed country-wide in the US.
Guidelines are lacking to standardize care in the ED, but there is a consensus that extensive
routine laboratory testing is unnecessary.

Conclusions:
Evaluation of physical stability, known as medical clearance, is a process best
customized to every patient’s individual needs. However, requirements of admitting psychiatric
inpatient facilities may conflict with recommendations of ancillary testing.
Valor de uso, capitalismo y política en Bolívar Echeverría
Authors: Lomelí Gamboa Sergio 
Published: October 2019

This article studies Bolívar Echeverría’s development of the ‘use value’ theory, and highlights its Marxian and existentialist influences. In order to accomplish this, in the first section of the paper I review the relationship between Sartre’s and Marx’s theoretical productions and point out that the common ground between them, according to Sartre, is that both understand that liberty, understood as self-production, is the basis for the human condition. I posit that Echeverría agrees with Sartre regarding this point. In the second section of the paper, I analyze Echeverría’s further development of Marx’s take on ‘use value’, and point out the relationship that Echeverría stablishes between use value, liberty and the political realm. I conclude my paper suggesting that Echeverría’s contribution opens a possible horizon of reflection, which has been unattended by Marxian political views.
Error evidente, culpa y tipicidad en las infracciones aduaneras
Authors: González Bianchi Pablo 
Published: October 2019

Las infracciones aduaneras son una especie de infracciones administrativas. A ellas son aplicables los principios generales del derecho punitivo. Sin embargo, tales infracciones tienen características distintivas, debido a las funciones especiales de la Administración de Aduanas y a institutos como la declaración en aduana, un error evidente (este último se dictaminó legalmente y con características y consecuencias analizadas a fondo por especialistas y tribunales en Uruguay y en Argentina). La ley aduanera punitiva, así como la ley tributaria, contemplan cierto número de sanciones. Esto se debe a la existencia de una determinación concreta del valor legalmente protegido. En los aspectos no contemplados, el régimen de infracciones aduaneras debe completarse con los conceptos y principios del derecho punitivo en general y del derecho penal, en particular, que han desarrollado los conceptos de culpabilidad, mala conducta intencional y tipicidad muy profundamente. Esto incluso cuando el legislador haya mantenido en el nuevo Código Aduanero Uruguayo rastros de la responsabilidad objetiva para ciertas infracciones. El error como medio de exclusión de culpabilidad, presenta particularidades teniendo en cuenta la existencia del concepto de error evidente en el Derecho aduanero. En este trabajo se procura desarrollar los conceptos mencionados y examinar ciertas infracciones aduaneras previstas en la ley local.
Las infracciones aduaneras son una especie de infracciones administrativas. A ellas son aplicables los principios generales del derecho punitivo. Sin embargo, tales infracciones tienen características distintivas, debido a las funciones especiales de la Administración de Aduanas y a institutos como la declaración en aduana, un error evidente (este último se dictaminó legalmente y con características y consecuencias analizadas a fondo por especialistas y tribunales en Uruguay y en Argentina). La ley aduanera punitiva, así como la ley tributaria, contemplan cierto número de sanciones. Esto se debe a la existencia de una determinación concreta del valor legalmente protegido. En los aspectos no contemplados, el régimen de infracciones aduaneras debe completarse con los conceptos y principios del derecho punitivo en general y del derecho penal, en particular, que han desarrollado los conceptos de culpabilidad, mala conducta intencional y tipicidad muy profundamente. Esto incluso cuando el legislador haya mantenido en el nuevo Código Aduanero Uruguayo rastros de la responsabilidad objetiva para ciertas infracciones. El error como medio de exclusión de culpabilidad, presenta particularidades teniendo en cuenta la existencia del concepto de error evidente en el Derecho aduanero. En este trabajo se procura desarrollar los conceptos mencionados y examinar ciertas infracciones aduaneras previstas en la ley local.
PERENCANAAN DAN PERSIAPAN MENGHADAPI MASA PENSIUN
Authors: Hakim Siti Nurina 
Published: October 2019

his activity aims at proposing the contemplation and necessarytreatment to prepare workers in facing their retirement period so that theymay get rid of their anxiety which may disturb their life. Therefore, themanagement of an institution should give necessary training for theirworkers to prepare their retirement period (MPP). This activity is conductedusing some methods as speech, discussion, and consultation. The solutionis taken from the participants since they are aware of their own needs, wants,abilities and obstacles. The solution from the participants is expected tobe conducted and applied easily, since they obviously tend to obey thecommitment created by them. After conducting this activity, there aresome significant changes in discourse from the participants in terms ofretirement condition, the next activities to be committed and how to starta new activity.
PEMANFAATAN AIR SUNGAI BAWAH TANAH GUA SURUH UNTUK MASYARAKAT DESA PUCUNG, EROMOKO, WONOGIRI
Authors: Sigit Agus Anggoro , Priyono Kuswaji Dwi , Priyana Yuli 
Published: October 2019

The village has a population Eromoko Pucung in District 444 families (2,354 people) which includes 7 hamlet, in the dry season is always a shortage of clean water for daily use. At the peak of the dry season are forced to buy water being sold privately at a price of Rp200,000 / car tank (volume 4 m³) for the use of approximately 20 days. In order to overcome the problems of water needs, the Pucung Village Government took the initiative to manage groundwater resources that exist in the Suruh Cave. Removal activities river water underground community empowerment aimed at utilization of underground water in the Cave Have to solving the problem ofwater supply daily needs of society in Pucung Village, District Eromoko, Wonogiri. The success of water removal program is expected to reduce the price of 1 m³ water needs of the original with a maximum price of Rp 50,000 to Rp 5,000 only.
PENGEMBANGAN PETERNAKAN BERSIH DI DESA NGUNUT KECAMATAN JUMANTONO KABUPATEN KARANGANYAR
Authors: Chusniatun Chusniatun , Priyono Kuswaji Dwi , Harismah Kun , Suharjo Suharjo , Muhtadi Muhtadi , Putro Sartono 
Published: October 2019

In the Pemitra community service activities for development cleaner farming in Desa Ngunut Kecamatan Jumantono kabupaten Karanganyar, has been done for directing activities, training, and mentoring for farmers of cattle and chickens in Desa Ngunut, Jumantono, Karanganyar. In this Pemitra activities have been conductedbriefings and training on producing of liquid and solid organic fertilizer, planting cassava and sengon by utilizing manure, the introduction of biogas technology applications on cattle ranchers. The results that have been obtained from this Pemitra community activities that partners have been able to understand and have the skills for managing livestock clean the biogas technology applications, the use of probiotics or fermentator in farm management, made of solid and liquid organic fertilizer, as well as the use of organic fertilizer for agricultural development cassava and sengon. The constraints and problems had been faced by the partners were 1) lack of farmer groups that have organizational unity in designing, managing, implementing and evaluating the work program. So that the unity and continuity in performing community service activities can not be done well, 2) Most of the participants were active inpemitra was the village officials and their family, so not much give a breadth of benefits to the general public.