bluuebunny/crossref_metadata_2025_split huggingface dataset:
A transdiagnostic study of children with problems of attention, learning and memory (CALM)
Authors: Holmes Joni , Bryant Annie ,   the CALM Team, Gathercole Susan E. 
Published: April 2018

AbstractBackgroundA substantial proportion of the school-age population experience cognitive-related learning difficulties. Not all children who struggle at school receive a diagnosis, yet their problems are sufficient to warrant additional support. Understanding the causes of learning difficulties is the key to developing effective prevention and intervention strategies for struggling learners. The aim of this project is to apply a transdiagnostic approach to children with cognitive developmental difficulties related to learning to discover the underpinning mechanisms of learning problems.Methods / DesignA cohort of 1000 children aged 5 to 18 years is being recruited. The sample consists of 800 children with problems in attention, learning and / memory, as identified by a health or educational professional, and 200 typically-developing children recruited from the same schools as those with difficulties. All children are completing assessments of cognition, including tests of phonological processing, short-term and working memory, attention, executive function and processing speed. Their parents/ carers are completing questionnaires about the child’s family history, communication skills, mental health and behaviour. Children are invited for an optional MRI brain scan and are asked to provide an optional DNA sample (saliva).Hypothesis-free data-driven methods will be used to identify the cognitive, behavioural and neural dimensions of learning difficulties. Machine-learning approaches will be used to map the multi-dimensional space of the cognitive, neural and behavioural measures to identify clusters of children with shared profiles. Finally, group comparisons will be used to test theories of development and disorder.DiscussionOur multi-systems approach to identifying the causes of learning difficulties in a heterogeneous sample of struggling learners provides a novel way to enhance our understanding of the common and complex needs of the majority of children who struggle at school. Our broad recruitment criteria targeting all children with cognitive learning problems, irrespective of diagnoses and comorbidities, are novel and make our sample unique. Our dataset will also provide a valuable resource of genetic, imaging and cognitive developmental data for the scientific community.
The congruence effect is impaired in healthy aging: a relationship to event-related potentials and theta-alpha oscillations
Authors: Packard Pau A. , Steiger Tineke K. , Fuentemilla Lluis , Bunzeck Nico 
Published: April 2018

AbstractLong-term memory can improve when incoming information is congruent with known semantic information. This so-called congruence effect has widely been shown in younger adults but age-related changes and neural mechanisms remain unclear. Here, congruence improved recognition memory in younger and older adults (i.e. congruency effect), but – importantly – this effect decreased with age. Electroencephalography data show that, in both groups, congruence led to widespread differences in event-related potentials (ERPs) and alpha-beta oscillations (8-30 Hz), known to support semantic processing. Importantly, these ERP differences predicted increases in memory performance, especially for congruent items. Finally, age-related differences in memory were accompanied by a positive ERP and later decrease in theta-alpha (5-13 Hz) during encoding, which were greater in the younger group. Together, although semantic congruence generally increases long-term memory, the effect is less pronounced in the elderly. At the neural level, theta-alpha oscillations, previously linked to memory and attentional processes, provide a mechanistic explanation for such an age-related effect.
Polychrome: Creating and Assessing Qualitative Palettes With Many Colors
Authors: Coombes Kevin R. , Brock Guy , Abrams Zachary B. , Abruzzo Lynne V. 
Published: April 2018

AbstractAlthoughRincludes numerous tools for creating color palettes to display continuous data, facilities for displaying categorical data primarily use theRColorBrewerpackage, which is, by default, limited to 12 colors. Thecolorspacepackage can produce more colors, but it is not immediately clear how to use it to produce colors that can be reliably distingushed in different kinds of plots. However, applications to genomics would be enhanced by the ability to display at least the 24 human chromosomes in distinct colors, as is common in technologies like spectral karyotyping. In this article, we describe thePolychromepackage, which can be used to construct palettes with at least 24 colors that can be distinguished by most people with normal color vision.Polychromeincludes a variety of visualization methods allowing users to evaluate the proposed palettes. In addition, we review the history of attempts to construct qualitative color palettes with many colors.
Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry
Authors: Pulit Sara L. , Stoneman Charli , Morris Andrew P. , Wood Andrew R. , Glastonbury Craig A. , Tyrrell Jessica , Yengo Loïc , Ferreira Teresa , Marouli Eirini , Ji Yingjie , Yang Jian , Jones Samuel , Beaumont Robin , Croteau-Chonka Damien C. , Winkler Thomas W. , Consortium Giant , Hattersley Andrew. T. , Loos Ruth J. F. , Hirschhorn Joel N. , Visscher Peter M. , Frayling Timothy M. , Glastonbury Craig A. , Yaghootkar Hanieh , Lindgren Cecilia M. 
Published: April 2018

AbstractOne in four adults worldwide are either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, is most informative for predicting risk of obesity sequellae, including cardiometabolic disease and cancer. We performed a genome-wide association study meta-analysis of body fat distribution, measured by waist-to-hip ratio adjusted for BMI (WHRadjBMI), and identified 463 signals in 346 loci. Heritability and variant effects were generally stronger in women than men, and we found approximately one-third of all signals to be sexually dimorphic. The 5% of individuals carrying the most WHRadjBMI-increasing alleles were 1.62 times more likely than the bottom 5% to have a WHR above the thresholds used for metabolic syndrome. These data, made publicly available, will inform the biology of body fat distribution and its relationship with disease.
Structural mechanism for Bruton’s tyrosine kinase activation at the cell membrane
Authors: Wang Qi , Pechersky Yakov , Sagawa Shiori , Pan Albert C. , Shaw David E. 
Published: April 2018

AbstractBruton’s tyrosine kinase (Btk) is critical for B-cell proliferation and activation, and the development of Btk inhibitors is a vigorously pursued strategy for the treatment of various B-cell malignancies. A detailed mechanistic understanding of Btk activation has, however, been lacking. Here, inspired by a previous suggestion that Btk activation might depend on dimerization of its lipid-binding PH-TH module on the cell membrane, we performed long-timescale molecular dynamics simulations of membrane-bound PH-TH modules and observed that they dimerized into a single predominant conformation. We found that the phospholipid PIP3 stabilized the dimer allosterically by binding at multiple sites, and that the effects of PH-TH mutations on dimer stability were consistent with their known effects on Btk activity. Taken together, our simulation results strongly suggest that PIP3-mediated dimerization of Btk at the cell membrane is a critical step in Btk activation.
Kif18A promotes Hec1 dephosphorylation to coordinate chromosome alignment with kinetochore microtubule attachment
Authors: Kim Haein , Stumpff Jason 
Published: April 2018

SUMMARYMitotic chromosomes are spatially confined at the spindle equator just prior to chromosome segregation through a process called chromosome alignment. Alignment requires temporal coordination of kinetochore microtubule attachment and dynamics. However, the molecular mechanisms that couple these activities are not understood. Kif18A (kinesin-8) suppresses the dynamics of kinetochore microtubules to promote chromosome alignment during metaphase. Loss of Kif18A function in HeLa and primordial germ cells leads to alignment defects accompanied by a spindle assembly checkpoint (SAC)-dependent mitotic arrest, suggesting the motor also plays a role in regulating kinetochore-microtubule attachments. We show here that Kif18A increases attachment by promoting dephosphorylation of the kinetochore protein Hec1, which provides the primary linkage between kinetochores and microtubules. This function requires a direct interaction between the Kif18A C-terminus and protein phosphatase-1 (PP1). However, the Kif18A-PP1 interaction is not required for chromosome alignment, indicating that regulation of kinetochore microtubule dynamics and attachments are separable Kif18A functions. Mitotic arrest in Kif18A-depleted cells is rescued by expression of a Hec1 variant that mimics a low-phosphorylation state, indicating that Kif18A-dependent Hec1 dephosphorylation is a key step for silencing the checkpoint and promoting mitotic progression. Our data support a model in which Kif18A provides positive feedback for kinetochore microtubule attachment by directly recruiting PP1 to dephosphorylate Hec1. We propose that this function works synergistically with Kif18A’s direct control of kinetochore microtubule dynamics to temporally coordinate chromosome alignment and attachment.
Differential requirements of tubulin genes in mammalian forebrain development
Authors: Bittermann Elizabeth , Liegel Ryan P. , Menke Chelsea , Timms Andrew , Beier David R. , Kline-Fath Beth , Saal Howard M. , Stottmann Rolf W. 
Published: April 2018

ABSTRACTTubulin genes encode a series of homologous proteins used to construct microtubules which are essential for multiple cellular processes. Neural development is particularly reliant on functional microtubule structures. Tubulin genes comprise a large family of genes with very high sequence similarity between multiple family members. Human genetics has demonstrated that a large spectrum of cortical malformations results from de novo heterozygous mutations in tubulin genes. However, the absolute requirement for most of these genes in development and disease has not been previously tested in genetic, loss of function models. Here we present two novel pathogenic tubulin alleles: a human TUBA1A missense variant with a phenotype more severe than most tubulinopathies and a mouse ENU allele of Tuba1a. Furthermore, we directly test the requirement for Tuba1a, Tuba8, Tubb2a and Tubb2b in the mouse by deleting each gene individually using CRISPR-Cas9 genome editing. We show that loss of Tuba8, Tubb2a or Tubb2b does not lead to cortical malformation phenotypes or impair survival. In contrast, loss of Tuba1a is perinatal lethal and leads to significant forebrain dysmorphology. Thus, despite their functional similarity, the requirements for each of the tubulin genes and levels of functional redundancy are quite different throughout the gene family. The ability of the mouse to survive in the absence of some tubulin genes known to cause disease in humans suggests future intervention strategies for these devastating tubulinopathy diseases.
MYBPC3 Mutations cause Hypertrophic Cardiomyopathy by Dysregulating Myosin: Implications for Therapy
Authors: Toepfer Christopher N. , Wakimoto Hiroko , Garfinkel Amanda C. , McDonough Barbara , Liao Dan , Jiang Jianming , Tai Angela , Gorham Josh , Lunde Ida G. , Lun Mingyue , Lynch Thomas L. , Sadayappan Sakthivel , Redwood Charles S. , Watkins Hugh , Seidman Jonathan , Seidman Christine 
Published: April 2018

AbstractThe mechanisms by which truncating mutations in MYBPC3 (encoding cardiac myosin binding protein-C; cMyBPC) or myosin missense mutations cause hyper-contractility and poor relaxation in hypertrophic cardiomyopathy (HCM) are incompletely understood. Using genetic and biochemical approaches we explored how depletion of cMyBPC altered sarcomere function. We demonstrate that stepwise loss of cMyBPC resulted in reciprocal augmentation of myosin contractility. Direct attenuation of myosin function, via a damaging missense variant (F764L) that causes dilated cardiomyopathy (DCM) normalized the increased contractility from cMyBPC depletion. Depletion of cMyBPC also altered dynamic myosin conformations during relaxation - enhancing the myosin state that enables ATP hydrolysis and thin filament interactions while reducing the super relaxed conformation associated with energy conservation. MYK-461, a pharmacologic inhibitor of myosin ATPase, rescued relaxation deficits and restored normal contractility in mouse and human cardiomyocytes with MYBPC3 mutations. These data define dosage-dependent effects of cMyBPC on myosin that occur across all phases of the cardiac cycle as the pathophysiologic mechanisms by which MYBPC3 truncations cause HCM. Therapeutic strategies to attenuate cMyBPC activity may rescue depressed cardiac contractility in DCM patients, while inhibiting myosin by MYK-461 should benefit the substantial proportion of HCM patients with MYBPC3 mutations.One Sentence SummaryAnalyses of cardiomyocytes with hypertrophic cardiomyopathy mutations in MYBPC3 reveal that these directly activate myosin contraction by disrupting myosin states of relaxation, and that genetic or pharmacological manipulation of myosin therapeutically abates the effects of MYBPC3 mutations.
Triangulation
Authors: Jackson Emerson Abraham 
Published: April 2018

Purpose
The purpose of this paper is to provide forum for critical discourses in the area of retroduction thinking in the re-orientation of social sciences research at the Bank of Sierra Leone. It is acknowledged that economic research at the bank is more oriented towards the orthodox approach (Keynesian, etc.), while that of the un-orthodox (heterodox) view is being blighted by the need to prove economic theory application without much consideration given to the imperfect market economic conditions faced in the country.

Design/methodology/approach
The methodology of the paper is based on critical theoretical literature review of documents and also the assessment of current approach to research practices at the Bank of Sierra Leone.

Findings
There is actually a pool of professionals from different backgrounds, whose passion have been coordinated to embrace the idea of integrating variety of triangulation approaches (methodological, theoretical, data, and investigator) in their pursuit of exploring best practices for policy research at the bank. Research is an ontological journey and the process of its epistemological inquiry requires pool of experts, drawn from wide range of backgrounds (mainstream Social Sciences, Mathematical Science, etc.), whose approaches are pertinent in the pursuit of human discovery, and particularly for policy development, as in the case with the Bank of Sierra Leone. This work has highlighted several salient recommended points for future action in the lead towards energizing research at the bank.

Originality/value
The effort to provide this paper is very original, which is based on the author's experience of working in a research focused environment. This paper will be of value to future pursuance of work in promoting triangulation research at the Bank of Sierra Leone. It is hoped that the outcome of this will spearhead mixture of professional engagement of work activities that is geared towards addressing effective policy formulation at the bank in meeting its key objective (maintaining price stability).
How job resources and personal resources influence work engagement and burnout
Authors: Kotze Martina 
Published: April 2018

PurposeThe purpose of this paper is to present a model of the relationships between personal resources (Psychological Capital (PsyCap)) and satisfaction with job resources, and their effect on work engagement and burnout.Design/methodology/approachData were collected from a convenience sample of 407 full-time employees from various public and private sector organisations, using a questionnaire consisting of PsyCap (PCQ-24), the Utrecht Work Engagement Scales, the Maslach Burnout Inventory, and a questionnaire measuring job resources (Parker and Hyett, 2011). The data were analysed using variance-based structural equation modelling (SmartPLS 3).FindingsThe influence of employees’ satisfaction with job resources on both dimensions of burnout (emotional exhaustion and cynicism) was negative and statistically significant. Satisfaction with job resources had a statistically significant positive influence on both dimensions of work engagement (vigour and dedication). PsyCap had a statistically significant positive influence on satisfaction with job resources. Satisfaction with job resources partially mediated the influence of PsyCap on emotional exhaustion and cynicism, and partially on vigour and dedication.Research limitations/implicationsAs this was an exploratory study, it used a convenience sample and a variance-based approach to structural equation modelling (SmartPLS). It is suggested that future researchers replicate the model in different contexts to corroborate the proposed relationships using larger samples, probability-based sampling and a covariance-based approach to structural equation modelling.Practical implicationsManagement must realise that employees’ satisfaction with job resources plays a central role in their work engagement and burnout levels. Workplace practices that reflect respect and care for the employee and the development of employees’ personal resources (i.e. PsyCap) will improve work engagement and reduce burnout.Originality/valueThis paper fills a gap in the literature by explaining how personal resources (PsyCap) and job resources (the organisation’s perceived respect for the employee and employer care) influence work engagement and burnout via mediation paths.
The day-of-the-week effect: South African stock market indices
Authors: du Toit Elda , Hall John Henry , Pradhan Rudra Prakash 
Published: April 2018

PurposeThe presence of a day-of-the-week effect has been investigated by many researchers over many years, using a variety of financial data and methods. However, differences in methodology between studies could have led to conflicting results. The purpose of this paper is to expand on an existing study to observe whether an analysis of the same data set with some added years and using a different statistical technique provide the same results.Design/methodology/approachThe study examines the presence of a day-of-the-week effect on the Johannesburg Stock Exchange (JSE) indices for the period March 1995-2016, using a GARCH model.FindingsThe findings show that, contrary to the original study, the day-of-the week effect is present in both volatility and return equations. The highest and lowest returns are observed on Monday and Friday, respectively, while volatility is observed on all five days from Monday to Friday.Originality/valueThis study adds to the existing literature on day-of-the-week effect of JSE indices, where different patterns or, in some cases, no pattern have been noted. Few previous studies on the day-of-the-week effect observed the effect at micro-level for separate industries or made use of a GARCH model. The present study thus expands on the study of Mbululu and Chipeta (2012), by adding four additional observation years and using a different statistical technique, to observe differences that arise from a different time period and statistical technique. The results indicate that a day-of-the-week effect is mostly a function of the statistical technique applied.
Entrepreneurship education research in Nigeria: current foci and future research agendas
Authors: Yatu Lemun , Bell Robin , Loon Mark 
Published: April 2018

PurposeEntrepreneurship education plays a crucial role in the development of entrepreneurs and the enhancement of entrepreneurial activities in every economy. This paper presents the findings of a review of Nigerian entrepreneurship education literature published in 20 journals over a 16-year period. The purpose of this paper is to examine research contributions in the field of entrepreneurship education within the Nigerian context, with the aim of understanding the focus and the different research areas covered by researchers in this area, and to make suggestions that can guide scholars in their future research contributions.Design/methodology/approachSystematic literature reviews are recognized methods for conducting evidence-based research. The study adopted a systematic literature review approach, drawing from a computerized search of five selected databases, using predetermined key words by the researchers.FindingsThe main finding of this paper is that related concepts like skills, intention, drive and attitude have been used in expounding discussions on the outcome of entrepreneurship education, but very little has been written on entrepreneurial mindset, which other studies have suggested is a crucial point in the journey of an entrepreneur (Reed and Stoltz, 2011; Neneh, 2012). Furthermore, learning and teaching of entrepreneurship in the Nigerian higher education institutions seem to be more focused on creating awareness about entrepreneurship, as against the experiential approach that scholars have argued to be a prerequisite for developing the next generation of entrepreneurs (Bell, 2015). The study also found that over 80 percent of the reviewed articles are published in journals not ranked or indexed in the ABS journal rankings or the Scopus database.Research limitations/implicationsThe paper is limited since it is based on a review of literature from a selected range of databases, covering a specific time span. This potentially excludes other studies outside this time span. Scholarship in this area and context will benefit greatly when researchers target, choose and engage the higher ranked and more impactful journals as the outlet for their research outputs.Practical implicationsAt a time when efforts are being made to address socioeconomic issues like poverty and unemployment through mainstream training in entrepreneurship education, this paper provides a better understanding of the state of research in this context, by highlighting the potential gaps as to where research investigation is needed for better policy formulation and guiding future research.Originality/valueThere are limited studies that focus on the issue of entrepreneurial mindset in entrepreneurship education in Nigeria. Overall, this paper identifies an important gap in the literature that warrants future research.
The implementation of palm oil plantation business licensing
Authors: Rusli Zaili 
Published: April 2018

Purpose
This study aims to describe and dig deeper into the subject and object, a person, institution or community, based on observations and interviews conducted, and to provide an analysis of what was found in the field and connect it with the concept of relevant theory.

Design/methodology/approach
An explanatory research method was conducted using qualitative research approaches to explain and explore in depth the subject and object, which are a person, an institution or a community.

Findings
Results of research show that the implementation of the palm oil plantation business licensing in Siak is not optimal. Factors that affect the implementation of palm oil plantation business licensing in Siak need to be addressed in a stepwise manner, to increase dissemination to the target and transform information that is clear and consistent. Develop SOP clear so that law enforcement can work and improve the quality and quality of the apparatus implementing policies.

Originality/value
A quality research approach has been used to assess the implementation of palm oil business licensing at the Forest and Land of Forestry and Plantation Office (Dishutbun) of Siak Regency, Riau, Indonesia.