bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supply Chain Disruptions and Business Continuity: An Empirical Assessment
Authors: Azadegan Arash , Mellat Parast Mahour , Lucianetti Lorenzo , Nishant Rohit , Blackhurst Jennifer 
Published: June 2019

ABSTRACTAre business continuity programs (BCPs) useful in improving company performance? Risk management research suggests that BCPs are important in response and recovery from disruptions. However, critics suggest that BCPs rely too much on known risks and are overly complicated. This creates a decision dilemma regarding whether to invest in BCPs or not. Using two empirical studies, this manuscript offers theoretical and empirical evidence as to whether BCPs help limit the damage caused by supply chain disruptions and improve company financial performance. Using structural contingency and organizational information processing theories, the study develops hypotheses on how BCPs channel resources to recover from supply chain disruptions, contingent on a company's flexible or procedural response orientation. In Study‐1, the hypotheses are tested based on a combination of subjective (Likert‐based responses) and objective (historical financial performance) data gathered and matched from a cross‐section of Italian companies. Results suggest that BCPs are beneficial to companies with a procedural or flexible orientation in limiting the damage caused by supply chain disruptions. Companies with strong BCPs show better financial performance in comparison to their competition. In Study‐2, a vignette‐based factorial experiment is used to offer insight on how managers perceive the effect of flexible or procedural response orientation on limiting the operational damage of disruptions. Finally, post‐hoc analyses using fuzzy set qualitative comparative analysis (fsQCA) offers further evidence of a strong link between BCPs and financial performance (return on assets).
Do GLP‐1RAs and SGLT‐2is reduce cardiovascular events in black patients with type 2 diabetes? A systematic review and meta‐analysis
Authors: Mishriky Basem M. , Powell James R. , Wittwer Jennifer A. , Chu Jennifer X. , Sewell Kerry A. , Wu Qiang , Cummings Doyle M. 
Published: June 2019

AbstractAimsWhile recent cardiovascular safety trials (CVST) concerning newer diabetes medications included mostly white participants, results are being generalized to all races in recent guidelines. This raises a controversial question regarding the appropriateness of applying CVST data to black patients with type 2 diabetes.Materials and methodsWe searched for randomized trials comparing diabetes medications to placebo in type 2 diabetes and investigated three‐ or four‐point major adverse cardiovascular events (MACE). Data concerning black patients were then extracted. As the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) updated their recommendations for patients with established cardiovascular risk based on the CVST showing cardiovascular benefit, we performed a sensitivity analysis by including those trials only.ResultsA total of 11 trials were included, investigating a glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) in five, a sodium‐glucose co‐transporter‐2 inhibitor (SGLT‐2i) in two and dipeptidyl peptidase‐4 inhibitors (DPP‐4i) in four. Of the 102 416 participants enrolled in the included trials, only 4601 were black (4.5%). Pooled results showed no significant difference in the incidence of MACE among diabetes medications (GLP‐1RA, SGLT‐2i or DPP‐4i) and placebo in black patients with type 2 diabetes (relative risk [RR] [95% CI], 0.94 [0.77,1.16]). Restricting the analysis to different classes of diabetes medication, the results remained non‐significant. Restricting the analysis to CVST with significant outcomes, the results remained non‐significant (RR [95% CI], 0.97 [0.68,1.39]).ConclusionsGiven that black patients with type 2 diabetes were not well represented in CVSTs and such trials were underpowered to evaluate racial differences, it remains unclear whether GLP‐1RAs or SGLT‐2is would reduce cardiovascular risk in such patients, and additional studies targeting black patients are urgently needed.
Same, Similar, or Something Completely Different? Calibrating Student Surveys and Classroom Observations of Teaching Quality Onto a Common Metric
Authors: van der Lans Rikkert M. , van de Grift Wim J.C.M. , van Veen Klaas 
Published: June 2019

AbstractUsing item response theory, this study explores whether student survey and classroom observation items can be calibrated onto a common metric of teaching quality. The data comprises 269 lessons of 141 teachers that were scored on the International Comparative Analysis of Learning and Teaching (ICALT) observation instrument and the My Teacher student survey. Using Rasch model concurrent calibration, items from both instruments were calibrated onto a common one‐dimensional metric of teaching quality. Most items were found to fit the model. Challenges pertain mainly to items measuring teaching students learning strategies and differentiation. Explanations for these difficulties are discussed.
High health care costs in minority groups of older US Medicare beneficiaries with epilepsy
Authors: Pisu Maria , Richman Joshua , Szaflarski Jerzy P. , Funkhouser Ellen , Dai Chen , Juarez Lucia , Faught Edward , Martin Roy C. 
Published: June 2019

AbstractObjectiveTo examine health care costs in diverse older Medicare beneficiaries with epilepsy.MethodsUsing 2008‐2010 claims data, we conducted a longitudinal cohort study of a random sample of Medicare beneficiaries augmented for minority representation. Epilepsy cases (n = 36 912) had ≥1 International Classification of Diseases, Ninth Edition (ICD‐9) 345.x or ≥2 ICD‐9 780.3x claims, and ≥1 antiepileptic drug (AED) in 2009; new cases (n = 3706) had no seizure/epilepsy claims nor AEDs in the previous 365 days. Costs were measured by reimbursements for all care received. High cost was defined as follow‐up 1‐year cost ≥ 75th percentile. Logistic regressions examined association of high cost with race/ethnicity, adjusting for demographic, clinical, economic, and treatment quality factors. In cases with continuous 2‐year data, we obtained costs in two 6‐month periods before and two after the index event.ResultsCohort was ~62% African Americans (AAs), 11% Hispanics, 5% Asians, and 2% American Indian/Alaska Natives. Mean costs in the follow‐up were ~$30 000 (median = $11 547; new cases, mean = $44 642; median = $25 008). About 19% white compared to 27% AA cases had high cost. AA had higher odds of high cost in adjusted analyses (odds ratio [OR] = 1.20, 95% confidence interval [CI] = 1.11‐1.29), although this was only marginally significant when adjusting for AED adherence (OR = 1.09, 95% CI = 1.01‐1.18, P = 0.03). Factors associated with high cost included ≥1 comorbidity, neurological care, and low AED adherence. Costs were highest at ~$17 000 in the 6 months immediately before and after the index event (>$29 000 for new cases).SignificanceThe financial sequelae of epilepsy among older Americans disproportionally affect minorities. Studies should examine contributors to high costs.
Predation risk and habitat complexity modify intermediate predator feeding rates and energetic efficiencies in a tri‐trophic system
Authors: Kolar Vojtech , Boukal David S. , Sentis Arnaud 
Published: June 2019

Abstract

To understand the effects of environmental changes on ecosystems, it is important to determine the factors and mechanisms influencing the strength of species interactions in food webs. However, joint effects of predation risk and additional environmental factors on species interaction strengths in multitrophic systems remain largely unexplored, leaving a substantial gap in our understanding of the links between local environmental characteristics and food web properties.

To fill this gap, we investigated the effects of habitat complexity and predation risk by top predatory dragonfly larvae (Aeshna cyanea) on feeding rates and energetic efficiency (i.e. the ratio of acquired and expended energy) of the larvae of three intermediate predatory odonate species (Libellula quadrimaculata, Sympetrum sanguineum, and Ischnura elegans) preying on cladocerans.

We hypothesised that predation risk would decrease the feeding rate, especially in the structurally simple habitat, and increase the metabolic rate of all intermediate predators. We also expected higher feeding rates of intermediate predators using aquatic vegetation as a perching site (i.e. Sympetrum and Ischnura) in the structurally complex habitat. Finally, we expected to observe habitat‐ and predation risk‐dependent energetic efficiencies of the intermediate predators driven by changes in feeding and metabolic rates.

The effect of predation risk on feeding rates was species specific and differed between the structurally simple and complex habitat. Habitat complexity increased feeding rates but only in the absence of predation risk. Moreover, predation risk signalled by chemical cues significantly increased Sympetrum vulgatum feeding rates but did not influence the feeding rates of the two other intermediate predators.

Metabolic rates varied among the three intermediate predators but were not affected by predation risk. Estimated energetic efficiency decreased with intermediate predator body mass and depended, to a lesser extent, on the interactive effect of habitat complexity and predation risk.

Our results imply that the effects of habitat complexity and predation risk on trophic interactions are likely to be determined by traits related to foraging and defence of the intermediate predators and their habitat domains, and that energetic efficiency is mainly determined by predator mass. Given that habitat complexity and predation risk can vary substantially across habitats, we conclude that it is important to consider habitat complexity and predation risk to better understand and predict the effects of environmentally driven variations on trophic interaction strength and metabolic rates that underlie the energetic efficiency of individual consumers. This has important implications for population and community dynamics as well as ecosystem functioning.
Postmarketing safety and effectiveness of recombinant factor IX (nonacog alfa) in Japanese patients with haemophilia B
Authors: Fukutake Katsuyuki , Taki Masashi , Matsushita Tadashi , Sakai Michio , Takata Ami , Yamaguchi Hiromi , Karumori Toshiyuki 
Published: June 2019

AbstractIntroductionIn 2010, nonacog alfa became the first recombinant factor IX (rFIX) available in Japan for patients with haemophilia B.AimTo determine real‐world safety (adverse events, incidence of inhibitors) and effectiveness of nonacog alfa in Japan.MethodsThis multicentre, prospective, observational, postmarketing surveillance study enrolled previously treated and untreated patients (PTPs and PUPs, respectively) who were observed for 1 and 2 years, respectively, after initiating nonacog alfa therapy. Safety and effectiveness were assessed for each treatment type. Annualized bleeding rate (ABR) and incremental recovery of rFIX were also evaluated.ResultsOverall, 312 of 314 patients enrolled from 173 sites were eligible for the safety analysis set (PTPs, 281; PUPs, 28; other, 3). Mean age was 25.4 (PTPs) and 14.8 (PUPs) years. Haemophilic severity ranged from mild to severe, and 133 (42.6%) patients had haemophilic arthropathy. Of 285 patients (PTPs, 257; PUPs, 28) in the effectiveness set, 112 received on‐demand treatment for 1161 bleeding episodes (effectiveness rate, 93.7%) and 185 received routine prophylaxis (effectiveness rate, 95.5%). No spontaneous bleeding was observed in 52.4% of patients during prophylactic treatment. Median ABR was lower during routine prophylaxis (2.0) vs the rest of the observation period (8.3). A weak negative correlation was found between body weight and the reciprocal of rFIX recovery. Eleven adverse drug reactions occurred in 7 PTPs (2.2% [7/312]); recurrence of inhibitor was observed in 1 patient, but no new inhibitor developed in PTPs or PUPs.ConclusionNonacog alfa therapy is safe and effective in the real‐world scenario in Japan.
Analytical investigation of 14th century stained glass windows from Santa Croce Basilica in Florence
Authors: Verità Marco , Bracci Susanna , Porcinai Simone 
Published: June 2019

AbstractThe Basilica di Santa Croce (Basilica of the Holy Cross) is the major Franciscan church in Florence (Italy). Among the prominent masterpieces preserved in this church, there are 22 medieval stained glass windows. Between 2000 and 2013, the Opera di Santa Croce started a restoration campaign of six of the most important ones, dated 14th c. In this paper, the archaeometric data collected during the restoration campaign are reported. Two major base glass compositions (potash‐lime‐silica and soda‐lime‐silica) were identified by quantitative chemical analysis. Results are compared with similar investigations on Italian stained glass windows of the 14th‐15th centuries and many similarities are highlighted. Some interesting “secrets” of the coloring techniques based also on multilayer glass pieces were revealed. Finally, SEM‐EDS analyses allowed the main weathering glass phenomena to be investigated.
Recovery in early stage breast cancer—An Australian longitudinal study
Authors: Edward Karen‐leigh , Chipman Mitchell , Stephenson John , Robinson Kayte , Giandinoto Jo‐Ann , Trisno Roth 
Published: June 2019

AbstractBackgroundThe majority of breast cancer patients will experience some level of emotional distress, with some patients having long‐term psychological maladjustment. Personal and social resources play a role in recovery yet the interplay between these factors warrants further examination. This study aimed to investigate the interaction of psychosocial factors impacting women in their breast cancer trajectory, at 2 years or less following diagnosis (stages I‐III).DesignA longitudinal cohort study approach was used in this study.MethodsThe sample consisted of n = 49 participants. Data were collected between June 2013 and October 2013 and followed for 12 months across the trajectory of the disease.ResultsThe mean age was 56.6 years (SD 11.6 years). Most participants had stage I or stage II breast cancer. Time (over three time points—4 weeks, 6 months, and 12 months) after diagnosis was significantly associated with the body image (P = .003) and age (P = .004).ConclusionOlder women with breast cancer reported less concern regarding body image than their younger peers. These findings suggest that posttreatment younger women may require access to psychological support posttreatment.
Fast Kernel Smoothing of Point Patterns on a Large Network using Two‐dimensional Convolution
Authors: Rakshit Suman , Davies Tilman , Moradi M. Mehdi , McSwiggan Greg , Nair Gopalan , Mateu Jorge , Baddeley Adrian 
Published: June 2019

SummaryWe propose a computationally efficient and statistically principled method for kernel smoothing of point pattern data on a linear network. The point locations, and the network itself, are convolved with a two‐dimensional kernel and then combined into an intensity function on the network. This can be computed rapidly using the fast Fourier transform, even on large networks and for large bandwidths, and is robust against errors in network geometry. The estimator is consistent, and its statistical efficiency is only slightly suboptimal. We discuss bias, variance, asymptotics, bandwidth selection, variance estimation, relative risk estimation and adaptive smoothing. The methods are used to analyse spatially varying frequency of traffic accidents in Western Australia and the relative risk of different types of traffic accidents in Medellín, Colombia.
Prescription of renin‐angiotensin‐aldosterone system inhibitors (RAASi) and its determinants in patients with advanced CKD under nephrologist care
Authors: Pecoits‐Filho Roberto , Fliser Danilo , Tu Charlotte , Zee Jarcy , Bieber Brian , Wong Michelle M. Y. , Port Friedrich , Combe Christian , Lopes Antonio A. , Reichel Helmut , Narita Ichiei , Stengel Benedicte , Robinson Bruce M. , Massy Ziad ,   CKDopps Investigators
Published: June 2019

AbstractRenin‐angiotensin‐aldosterone system inhibitors (RAASi) are recommended for chronic kidney disease (CKD) patients. In this study, we describe RAASi prescription patterns in the Chronic Kidney Disease Outcomes and Practice Patterns Study (CKDopps) in Brazil, Germany, France, and the United States (US). 5870 patients (mean age 66‐72 years; congestive heart failure [CHF] in 11%‐19%; diabetes in 43%‐54%; serum potassium ≥5 in 20%‐35%) were included. RAASi prescription was more common in Germany (80%) and France (77%) than Brazil (66%) and the United States (52%), where the prevalence of prescription decreases particularly in patients with CKD stage 5. In the multivariable regression model, RAASi prescription was least common in the United States and more common in patients who were younger, had diabetes, hypertension, or less advanced CKD. In conclusion, RAASi prescription patterns vary by country, and by demographic and clinical characteristics. RAASi appear to be underused, even among patients with strong class‐specific recommendations. Although the reasons for this variation could not be fully identified in this cross‐sectional observation, our data indicate that the risk of hyperkalemia may contribute to the underuse of this class of agents in moderate to advanced CKD.
Artificial diet delivery system forPhilaenus spumarius, the European vector ofXylella fastidiosa
Authors: Cornara Daniele , Ripamonti Matteo , Morente Marina , Garzo Elisa , Bosco Domenico , Moreno Aranzazu , Fereres Alberto 
Published: June 2019

AbstractArtificial diets represent an essential tool for investigations on the intimate relationship between plant pathogens and their vectors. Previous research failed in devising an artificial diet delivery system for the meadow spittlebugPhilaenus spumarius, to date considered the most important vector of the bacteriumXylella fastidiosain Europe. Here, we describe a new delivery “tube system” by which we succeeded in artificial feeding ofP. spumariuswith holidic diets (one sucrose diet and two amino acids diets). Spittlebug probing and feeding behaviour on either the tube system or a traditional “flat system” realized out of a small Petri dish filled with diet and covered with stretched Parafilm®were observed in real time by video‐EPG (Electrical Penetration Graph), in order to assess the occurrence of ingestion and excretion. Moreover, we evaluatedP. spumariussurvival on either the tube system filled with the two holidic diets that gave the best EPG results or an empty tube system serving as control. Contrary to the flat system, where just brief stylet insertions through the Parafilm®were recorded, the spittlebug ingested the artificial diets when delivered with the tube system. Survival on the diets provided with the tube system was significantly greater than the control, with no differences between the diets tested. Furthermore, the tube system was suitable also for another spittlebug species shown to be a competent vector ofX. fastidiosa, that isNeophilaenus campestris. The tool we devised opens new perspectives for investigations onX. fastidiosa/spittlebugs interactions, as well as for the functional analysis of mutantX. fastidiosastrains in respect to insect colonization and transmission.
Influences of blackberry margins on population dynamics of Drosophila suzukii and grape infestation in adjacent vineyards
Authors: Weißinger Lisa , Schrieber Karin , Breuer Michael , Müller Caroline 
Published: June 2019

AbstractUnderstanding the dynamics of pest insect populations in relation to the presence of non‐crop habitats and infestation levels of adjacent crops is essential to develop sustainable pest management strategies. The invasive pest species Drosophila suzukii (Diptera: Drosophilidae) is able to utilize a broad range of host plants. In viticulture, scientific risk assessment for D. suzukii has only recently started and studies assessing the effects of field margins containing wild host plants on D. suzukii population dynamics and on infestation risks in adjacent vineyards are lacking. Thus, in a one‐year field study, the role of different field margins on fly abundance and crop infestation in adjacent vineyards of Vitis vinifera, variety “Pinot Noir,” were investigated. Different monitoring methods were conducted to assess fly distribution, sex ratio and grape infestation in 14 vineyards adjacent to field margins containing either blackberry (BB) Rubus spp. or non‐host (NH) plants. Our results show that blackberries strongly enhanced D. suzukii abundance within field margin vegetation all year long, whereas fly abundance in vineyards adjacent to BB margins was just enhanced in some seasonal periods. Moreover, the influence of BB margins was limited by distance. However, high fly numbers in BB field margins did result in zero egg infestation of “Pinot Noir” berries. These results may have important implications for winegrowers to make efficient management decisions: regardless of high abundance of adult D. suzukii, only grape berry monitoring can assess the actual infestation risk and the potential need to take management action.
Genetic diversity of piscine myocarditis virus in Atlantic salmon Salmo salar L. in Ireland
Authors: Tighe Andrew J. , Carlsson Jens , Morrissey Teresa , Swords Fiona , Ruane Neil M. 
Published: June 2019

AbstractPiscine myocarditis virus (PMCV) is a double‐stranded RNA virus which has been linked to cardiomyopathy syndrome (CMS) in Atlantic salmon (Salmo salar L.). The first recorded outbreak of CMS in Ireland occurred in 2012. Heart tissue samples were collected in the current study from farmed Atlantic salmon from various marine sites around Ireland, and the open reading frames (ORFs) 1 and 3 were amplified and sequenced in order to examine the genetic diversity of PMCV. Results showed PMCV to be largely homogenous in Irish samples, showing little genetic diversity. However, several amino acid positions within both ORF1 and ORF3 showed consistent variations unique to the Irish PMCV strains when compared with previously published Norwegian strains. The phylogeny generated in the present study suggests that PMCV may have been introduced into Ireland in two waves, both coming from the southern part of PMCV's range in Norway. In addition, over three‐quarters of the PMCV strains which were sequenced came from fish not exhibiting any clinical signs of CMS, suggesting that either PMCV is evolving to become less virulent in Ireland or Irish Atlantic salmon are developing immunity to the disease.