bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility Investigation of Ipsilateral Reoperations by Thoracoscopy for Major Lung Resection
Authors: Sun Weiyan , Zhang Lei , Li Zeyao , Chen Donglai , Jiang Gening , Hu Jian , Chen Chang 
Published: March 2019

Abstract
Background Video-assisted thoracoscopic surgery (VATS) has become the preferred approach for minimizing harm from thoracic operations. There is no report, however, which has discussed the feasibility of VATS in ipsilateral reoperation of major lung resection.
Methods The present study included patients who had undergone ipsilateral reoperation of major lung resection by VATS from October 2009 to May 2017. Referring clinical data were recruited for analysis.
Results Fourteen patients were recruited in the present study, including nine patients who underwent lobectomy and five who underwent segmentectomy during the second operation. Different hila were found in 6 patients, and pleural adhesions appeared in 10 patients. The average intraoperative blood loss was 203.6 ± 121.7 mL, and the mean operating room time was 2.2 ± 0.5 hours. There were no intraoperative deaths, and only one patient required conversion to thoracotomy. The average drainage time was 5.9 ± 4.6, and the mean hospital stay was 6.7 ± 4.2 days.
Conclusion Though it is technically demanding to safely handle the changed hilum structure caused by the last operation, major lung resection by VATS is feasible for ipsilateral reoperation in appropriate candidates.
Lateral Radial Head Subluxation as a Complication Following Proximal Ulnar Osteotomy or Ostectomy in Eight Dogs
Authors: Williams Heather , Arthurs Gareth , Burton Neil , Kulendra Elvin , Radke Heidi , Parsons Kevin 
Published: March 2019

Objectives The aim of this study was to report the complication of lateral radial head subluxation following proximal ulnar osteotomy (PUOO) or proximal ulnar ostectomy (PUOE) in eight dogs.
Materials and Methods Case records and diagnostic imaging of dogs developing lateral radial head subluxation following PUOO (n = 7) or PUOE (n = 2) were retrospectively reviewed. Information pertaining to clinical history, signalment, presenting condition, lameness grade, diagnostic imaging and initial surgery details, postoperative complications and their management were retrieved. Outcomes were established from subsequent clinical histories or telephone interviews with referring veterinarians. Comparison was made to a single-centre cohort without lateral radial head subluxation following PUOO or PUOE.
Results Eight dogs (median age: 9.5 months [range: 6 months–6 years], median weight 7.7 kg [range: 5–28 kg]) were included. Six dogs had a PUOO performed; five dogs had unilateral surgery and one had bilateral surgery. Two dogs had unilateral PUOE surgery. Median time to diagnosis of lateral radial head subluxation following surgery was 6.5 weeks (range: 2–20 weeks). Five of the eight dogs had surgical revision of lateral radial head subluxation. Resolution of lateral radial head subluxation was achieved in four dogs, with three achieving acceptable to good mobility. One dog had poor postoperative mobility. A fifth dog remained lame after revision surgery failure. Three dogs did not have revision surgery; two underwent limb amputation and one dog remained lame as revision surgery was declined.
Clinical Significance Lateral radial head subluxation is a potentially severe postoperative complication following PUOO or PUOE.
Age-Related Variances in Patients with Tibial Plateau Fractures
Authors: Oladeji Lasun O. , Worley John R. , Crist Brett D. 
Published: March 2019

AbstractTibial plateau fractures account for approximately 8% of fractures in the elderly population. Treatment strategies in the elderly are similar to those for younger patients; however, practitioners must account for the elevated comorbidity burden in this population. To date, few studies have analyzed age-based outcomes in patients with tibial plateau fractures. Therefore, the purpose of this study was to determine age-related variances in demographics, fracture characteristics, mechanism of injury, and complications. A 10-year retrospective review was conducted to identify patients who received treatment for a tibial plateau fracture. There were 351 patients (360 tibial plateau fractures) who were identified and subsequently stratified according to their age at the time of injury. Patients were classified as elderly if they were 65 years of age or older at the time of injury; all other patients were included in the control cohort. These two cohorts were analyzed using bivariate analysis to isolate for age-related variations with respect to risk factors, mechanism of injury, and complications. There were 351 patients (360 tibial plateau fractures) with a median follow-up of 1.84 ± 2.44 years who met inclusion criteria. There were a greater proportion of women in the elderly cohort as compared with the younger cohort (60.0 vs. 43.4%, p = 0.06). Elderly patients were significantly more likely to present with diabetes (33.3 vs. 16.1%, p = 0.01) or osteoporosis (14.3 vs. 1.6%, p = 0.001). Younger patients were significantly more likely to require further surgery to address ligament (12.6 vs. 0%, p = 0.008), meniscus (20.9 vs. 7.1%, p = 0.036), or cartilage pathology (13.6 vs. 0%, p = 0.005). There was no difference in the arthroplasty conversion rate (4.8% elderly vs. 7.9% control, p = 0.755). While elderly patients presented with a greater comorbidity burden, they had equivalent or better short-term outcomes when compared with their younger peers when treated with open reduction and internal fixation (ORIF). Despite the recent interest in primary total knee arthroplasty for elderly patients with tibial plateau fractures, the results of this study suggest that elderly patients may respond well when treated with ORIF following a tibial plateau fracture.
Posterior Reversible Encephalopathy Syndrome in an Adolescent with Acute Poststreptococcal Glomerulonephritis
Authors: Doğan Çağla Serpil , Aksoy Gülşah Kaya , Kutluk Muhammed Gültekin , Özkan Mehmet Burak 
Published: March 2019

AbstractPosterior reversible encephalopathy syndrome (PRES) is a rare but severe complication of acute poststreptococcal glomerulonephritis (APSGN) in children. A 13-year old boy was diagnosed with APSGN based on clinical, laboratory, and renal biopsy findings. On the third hospital day, his blood pressure (BP) was 130/80 mm Hg on antihypertensive and diuretic treatment. He then developed confusion, blurry vision, and changes in speech and behavior. Over the next few hours, his BP increased to 160/90 to 170/90 mm Hg (99th percentile, 135/90 mm Hg). Magnetic resonance imaging of the brain revealed prominent hyperintensities in the right temporal, right temporo-occipital, and right parieto-occipital gray, and white matter on T2-weighted and fluid-attenuated inversion recovery images, compatible with PRES (posterior reversible encephalopathy syndrome). Electroencephalography showed generalized epileptiform activity. After treatment with anticonvulsant and additional antihypertensive medications, his clinical symptoms and neuroimaging findings were resolved. Posterior reversible encephalopathy syndrome should be considered in the differential diagnosis of patients with APSGN developing sudden neurological symptoms without severe increases in BP.
Phenethyl isothiocyanate stimulates glucose uptake through the Akt pathway in C2C12 myotubes
Authors: Chiba Maiko , Ito Yoshiaki , Nagasawa Takashi 
Published: March 2019

ABSTRACT
Phenethyl isothiocyanate (PEITC) is an aromatic isothiocyanate present in cruciferous vegetables. Several studies have shown that isothiocyanates regulate various intracellular signaling pathways, and thereby show anti-inflammatory and detoxifying activities. However, little is known about the effects of PEITC on glucose metabolism. In this study, we examined whether PEITC promotes glucose utilization in mouse skeletal muscle cells, C2C12 myotubes. PEITC induced glucose uptake, glucose transporter 4 (Glut4) translocation to the plasma membrane, and activation of Akt and ERK in C2C12 cells. Inhibition of Akt suppressed PEITC-induced Glut4 translocation and glucose uptake, whereas ERK inhibition did not. Furthermore, PEITC increased phosphorylation of ErbB2 and ErbB3. Treatment with a pan-ErbB inhibitor reduced Akt activation and the subsequent glucose uptake induced by PEITC. These results indicate that PEITC promotes glucose utilization through the ErbB/Akt pathway in C2C12 myotubes. PEITC may therefore serve as a dietary constituent with beneficial effects on the carbohydrate metabolism.
Abbreviations: PEITC: phenethyl isothiocyanate; Glut4: glucose transporter 4; PI3K: phosphatidylinositide 3-kinase; Nrf2: erythroid−2-related factor; ARE: antioxidant response element; HO−1: heme oxygenase−1; NRG: neuregulin
Flagellum-mediated motility in Pelotomaculum thermopropionicum SI
Authors: Kosaka Tomoyuki , Goda Mutsumi , Inoue Manami , Yakushi Toshiharu , Yamada Mamoru 
Published: March 2019

ABSTRACT
The basic functions of a propionate-oxidizing bacterium Pelotomaculum thermopropionicum flagellum, such as motility and chemotaxis, have not been studied. To investigate its motility, we compared with that of Syntrophobacter fumaroxidans, an aflagellar propionate-oxidizing bacterium, in soft agar medium. P. thermopropionicum cells spread, while S. fumaroxidans cells moved downward slightly, indicating flagellum-dependent motility in P. thermopropionicum SI. The motility of P. thermopropionicum was inhibited by the addition of carbonyl cyanide m-chlorophenyl hydrazone, a proton uncoupler, which is consistent with the fact that stator protein, MotB of P. thermopropionicum, shared sequence homology with proton-type stators. In addition, 5-N-ethyl-N-isopropyl amiloride, an Na+ channel blocker, showed no inhibitory effect on the motility. Furthermore, motAB of P. thermopropionicum complemented the defective swimming ability of Escherichia coli ∆motAB. These results suggest that the motility of P. thermopropionicum SI depends on the proton-type flagellar motor.
Ultrafast dynamic evolution of multilevel systems in medium-strength laser fields
Authors: Wang Zhenhao , Shi Guoqiang , He Yu , Wang Quanjun , Ding Jingjie , Sun Shaohua , Liu Zuoye , Hu Bitao 
Published: March 2019

Abstract
The ultrafast dynamic evolution of an atomic system under medium-strength laser fields is studied by performing transient absorption measurement. An analytical model developed from perturbation theory with a modified transition dipole moment is presented to explain the spectral features of the multilevel system. By fitting the measured absorption spectra to the model, the system’s dynamic evolution is quantified by different amplitude and phase modulation factors in the pump-probe and probe-pump scenarios. This study provides a way to understand laser-matter interaction in the transition area between the strong-field and weak-field regimes.
Magnetic Field Concentrator Based on the Superconducting Films with Nanosize Cuts
Authors: Ichkitidze L P , Belodedov M V , Selishchev S V , Telishev D V 
Published: March 2019

Abstract
Optimal active strip nanostructuring of a magnetic field concentrator based on superconducting films allows to further increase the concentration ratio of the device. The magnetically sensitive element was placed between two concentrator rings lying in the same plane without crossing. Calculated concentration coefficients F and F
0 of a planar concentrator with an active strip with nanosize cuts and without them. Different position of the cuts in the active strip of the concentrator were invastigated, as well as different values of the magnetically sensitive element width w
0 and the London penetration depth λ. In the calculations it was assumed that the width of the cut w
p coincides with the distance w
a between the ends of the near concentrator and magnetically sensitive element. The active strip width w
s and width of the superconducting branch were multiples of w
a . It turned out that as w
0 decreases, F
0 increases and F decreases but the total concentration coefficient F* = F
0
F increases. F* value for a concentrator based on the niobium film (λ ∼ 50nm ) is higher than for the concentrator based on films Y-123 or Bi-2223 (λ ≥ 250nm). The considered concentrator with nanosize cuts will increase the efficiency of combined magnetic field sensors, SQUIDs, and other sensors with a resolution of ≤ 1 pT.
Efficiency and sustainability of land-resource use on a small island
Authors: Noda Keigo , Iida Akiko , Watanabe Satoshi , Osawa Kazutoshi 
Published: March 2019

Abstract
Land resources are essential for humans to survive, and different methods of land- resource use depend largely on the local natural context and society. Here we propose a method to assess land-resource use in terms of efficiency and sustainability for three historical types of land-resource use in the Babeldaob Island, Republic of Palau: self-supply, resource development and nature conservation. Our proposed index of land-use efficiency makes comparisons possible among the types of land-resource use, considering both the natural and social conditions; land-use efficiency increased in the order of self-supply, nature conservation and resource development. At the same time, sustainability of land-resource use corresponded to population growth; when the population density was less or more than 15 capita km−2, self-supply and nature conservation were the most sustainable, respectively.
CP*Trends: An Online Tool for Comparing Cohort and Period Trends Across Cancer Sites
Authors: Holford Theodore R , Chen Huann-Sheng , Annett David , Krapcho Martin , Dorogaeva Asya , Feuer Eric J 
Published: March 2019

Abstract
Cohort or period components of trends can provide a rationale for new research or point to clues on the effectiveness of control strategies. Graphical display of trends guides models that quantify the experience of a population. In this paper, a method for smoothing rates by single year of age and year is developed and displayed to show the contributions of period and cohort to trends. The magnitude of the contribution of period and/or cohort in a model for trends may be assessed by the percentage of deviance explained and the relative contributions of cohort (C) and period (P) individually, known as the C-P score. The method is illustrated using Surveillance, Epidemiology, and End Results data (1975–2014) on lung and bronchial cancer mortality in females and prostate and colorectal cancer incidence in males. Smoothed age-period and age-cohort rates provide a useful first step in studies of etiology and the impact of disease control without imposing a restrictive model. We found that, in this data set, cohort predominates for female lung and bronchial cancer and period predominates for male prostate cancer. However, the effects change with age for male colorectal cancer incidence, indicating an age shift in relevant exposures. These methods are applied on an interactive website for both incidence and mortality at over 20 cancer sites in the United States.
Prognostic value of ratio of transmitral early filling velocity to early diastolic strain rate in patients with Type 2 diabetes
Authors: Lassen Mats Christian Højbjerg , Jensen Magnus T , Biering-Sørensen Tor , Møgelvang Rasmus , Fritz-Hansen Thomas , Vilsbøll Tina , Rossing Peter , Jørgensen Peter Godsk 
Published: March 2019

Abstract

Aims
The ratio of early mitral inflow velocity to global diastolic strain rate (E/e′sr) has recently emerged as a novel measure of left ventricular filling pressure. E/e′sr has in previous studies demonstrated to have good prognostic value in various patient populations. The aim of this study is to investigate the prognostic value of E/e′sr in a large cohort of patients with Type 2 diabetes in relation to cardiovascular morbidity and mortality.

Methods and results
In this prospective study, 848 Type 2 diabetic patients (mean age 63.6 ± 10.3 years, 64.7% male) underwent comprehensive echocardiographic examination including 2D speckle tracking in which E/e′sr along with novel and conventional echocardiographic variables were obtained. During follow-up (median: 4.8 years, interquartile range: 4.0–5.3), 122 (14.1%) met the composite outcome of cardiovascular disease, hospitalization, and mortality. Both E/e′sr and E/e′ were significantly associated with the outcome [E/e′sr: hazard ratio (HR) 1.07, 95% confidence interval (CI): 1.05–1.10; P < 0.001, per 0.10 m increase] and (E/e′: HR 1.07, 95% CI: 1.05–1.10; P = 0.001, per 1 unit increase). E/e′sr remained an independent predictor after multivariable adjustment for demographical, clinical, and echocardiographic parameters (HR 1.06, 95% CI: 1.01–1.12; P = 0.032, per 10 cm increase). The same was true for E/e′ (HR 1.09, 95% CI: 1.04–1.14; P < 0.001, per 1 unit increase). Additionally, E/e′sr provided incremental prognostic information beyond the UK ‘Prospective Diabetes Study risk engine’ 0.72 (0.68–0.77) vs. 0.74 (0.70–79), P = 0.040.

Conclusion
In patients with Type 2 diabetes, E/e′sr provides independent and incremental prognostic information regarding cardiovascular morbidity and mortality.
A case report: unmasking a singular culprit for cardiogenic shock: looking beyond the coronary tree
Authors: Almeida-Morais Luís , Portugal Guilherme , Cruz-Ferreira Rui 
Published: March 2019

Abstract

Background
Cardiogenic shock remains challenging in its therapy and aetiology.

Case summary
A 74-year-old woman admitted for cardiogenic shock requiring mechanical ventilation and high-dose inotropics and vasopressors with an electrocardiogram showing left ventricular (LV) lateral wall ischaemia had diffuse coronary artery disease but TIMI III flow in the coronary tree. An echocardiogram showed a suspicious mass invading the left ventricle and computed tomography scan revealed an advanced lung cancer with LV wall and pulmonary artery invasion as the cardiogenic shock cause.

Discussion
When managing cardiogenic shock, it is important to consider different and not obvious diagnosis. A high level of clinical suspicion and multimodality imaging assessment was very important in the present case to attain the diagnosis.
Trends across 20 years in multiple indicators of functioning among older adults in the Netherlands
Authors: Timmermans Erik J , Hoogendijk Emiel O , Broese van Groenou Marjolein I , Comijs Hannie C , van Schoor Natasja M , Thomése Fleur C F , Visser Marjolein , Deeg Dorly J H , Huisman Martijn 
Published: March 2019

Abstract

Background
Monitoring of trends in functioning of older adults provides indispensable information for health care policy. This study examined trends in multiple indicators of functioning among Dutch older adults across a period of 20 years.

Methods
Data from the Longitudinal Aging Study Amsterdam were used. We included 10 870 observations of 3803 respondents aged 64–84 years across seven waves (1992–12) and 931 observations of 603 respondents aged 85–94 years across four waves (2001–12). At each wave, 8 indicators of functioning were measured: multimorbidity, severe functional limitations, depression, anxiety, cognitive impairment, physical inactivity, loneliness and social isolation. In addition, a sum score (range: 0–8) of these indicators was calculated, with a score of ≥5 indicating ‘multiple problems.’ Trends in functioning over time were assessed using Generalized Estimating Equation analyses.

Results
In the 64-84-years-olds, the prevalence of multimorbidity increased over time [OR(year) = 1.06, 95% CI = 1.05–1.06], whereas the prevalence of the other indicators decreased [i.e. cognitive impairment, physical inactivity (in women) and loneliness (in women)] or remained stable [i.e. severe functional limitations, depression, anxiety, physical inactivity (in men), loneliness (in men) and social isolation]. In the 85-94-year-olds, the prevalence of severe functional limitations increased over time [OR(year) = 1.08, 95% CI = 1.02–1.13], whereas the prevalence of the other indicators remained stable. In both age groups, the prevalence of ‘multiple problems’ remained stable.

Conclusion
Unfavorable trends were observed in multimorbidity among 64-84-years-olds and in severe functional limitations among 85-94-year-olds. Favorable trends were found in cognitive impairment, physical inactivity (in women) and loneliness (in women) among 64–84-years-olds.
Personality and Falls Among Older Adults: Evidence From a Longitudinal Cohort
Authors: Canada Brice , Stephan Yannick , Sutin Angelina R , Terracciano Antonio 
Published: March 2019

Abstract

Objectives
Falls can have catastrophic consequences, especially for older adults. This study examined whether personality traits predict the incidence of falls in older age.

Method
Participants were older adults aged from 65 to 99 years (N = 4,759) drawn from the Health and Retirement Study. Personality traits and demographic factors were assessed at baseline. Falls were tracked for up to 11 years.

Results
Over the follow-up period, 2,811 individuals reported falls. Cox regression analyses that included demographic covariates indicated that lower conscientiousness and higher neuroticism increased the risk of falling. Disease burden, depressive symptoms, and physical inactivity mediated the associations between both traits and falls incidence, whereas smoking status and handgrip strength mediated the neuroticism–falls incidence association.

Discussion
This study provides new prospective evidence that personality predicts the incidence of falls in older adults and suggest that personality assessment may help identifying individuals at higher risk of falling.
Disrupting data sharing for a healthier ocean
Authors: Pendleton Linwood H , Beyer Hawthorne , Estradivari  , Grose Susan O , Hoegh-Guldberg Ove , Karcher Denis B , Kennedy Emma , Llewellyn Lyndon , Nys Cecile , Shapiro Aurélie , Jain Rahul , Kuc Katarzyna , Leatherland Terry , O’Hainnin Kira , Olmedo Guillermo , Seow Lynette , Tarsel Mick 
Published: March 2019

AbstractOcean ecosystems are in decline, yet we also have more ocean data, and more data portals, than ever before. To make effective decisions regarding ocean management, especially in the face of global environmental change, we need to make the best use possible of these data. Yet many data are not shared, are hard to find, and cannot be effectively accessed. We identify three classes of challenges to data sharing and use: uploading, aggregating, and navigating. While tremendous advances have occurred to improve ocean data operability and transparency, the effect has been largely incremental. We propose a suite of both technical and cultural solutions to overcome these challenges including the use of natural language processing, automatic data translation, ledger-based data identifiers, digital community currencies, data impact factors, and social networks as ways of breaking through these barriers. One way to harness these solutions could be a combinatorial machine that embodies both technological and social networking solutions to aggregate ocean data and to allow researchers to discover, navigate, and download data as well as to connect researchers and data users while providing an open-sourced backend for new data tools.