bluuebunny/crossref_metadata_2025_split huggingface dataset:
The complete genome sequence of the crayfish pathogen CandidatusParacoxiella cheracisn.g. n.sp. provides insight into pathogenesis and the phylogeny of the Coxiellaceae family
Authors: Ingle Danielle J. , Walsh Calum J. , Samuel Genevieve R. , Wick Ryan R. , Davidovich Nadav , Fiocchi Eleonora , Judd Louise M. , Elliman Jennifer , Owens Leigh , Stinear Timothy P. , Basso Andrea , Pretto Tobia , Newton Hayley J. 
Published: December 2024

ABSTRACTThe Coxiellaceae bacterial family, within the order Legionellales, is defined by a collection of poorly characterized obligate intracellular bacteria. The zoonotic pathogen and causative agent of human Q fever,Coxiella burnetii, represents the best characterized member of this family. Coxiellaceae establish replicative niches within diverse host cells and rely on their host for survival, making them challenging to isolate and cultivate within a laboratory setting. Here we describe a new genus within the Coxiellaceae family that has been previously shown to infect economically significant freshwater crayfish. Using culture-independent long-read metagenomics, we reconstructed the complete genome of this novel organism and demonstrate that the previously referred to as CandidatusCoxiella cheraxirepresents a novel genus within this family, herein denoted CandidatusParacoxiella cheracis. Interestingly, we demonstrate that CandidatusP. cheracisencodes for a complete, putatively functional Dot/Icm type 4 secretion system that likely mediates the intracellular success of this pathogen. In silico analysis defined a unique repertoire of Dot/Icm effector proteins and highlighted homologues of several importantC. burnetiieffectors including a homologue of CpeB that was demonstrated to be a Dot/Icm substrate inC. burnetii.IMPORTANCEUsing long-read sequencing technology we have uncovered the full genome sequence of CandidatusParacoxiellacheracis, a pathogen of economic importance in aquaculture. Analysis of this sequence has revealed new insight into this novel member of the Coxiellaceae family, demonstrating that it represents a new genus within this poorly characterized family of intracellular organisms. Importantly, the genome sequence reveals invaluable information that will support diagnostics and potentially both preventative and treatment strategies within crayfish breeding facilities. CandidatusP. cheracisalso represents a new member of Dot/Icm pathogens that rely on this system to establish an intracellular niche. CandidatusP. cheracispossesses a unique cohort of putative Dot/Icm substrates that constitute a collection of new eukaryotic cell biology manipulating effector proteins.
Spatiochemical Investigation of Potential Biocontrol Agents AgainstPhytophthora capsiciInfection in Tomato
Authors: Robinson Jamille Y. , Shepard Hawkins S. , Ambachew Daniel , Eyegheleme Peter J. , May Jody C. , Mmbaga Margaret T. , McLean John A. 
Published: December 2024

AbstractBiological control agents can offer an eco-friendly and more sustainable alternative to conventional chemical pesticides, providing protection against destructive pathogens, such asPhytophthora capsici,while reducing potential environmental harm associated with synthetic pesticide use in agricultural production systems. This work demonstrates the biocontrol effectiveness of variousBacillusspecies, includingBacillus vallismortis,Bacillus amyloliquefaciens, Bacillus thuringiensis,andBacillus subtilis, against the widespread plant pathogen,Phytophthora capsici. Our studies showed thatBacillus thuringiensisandBacillus subtilispromote plant growth and provide protection againstPhytophthora capsiciin bothin vitroandin vivogreenhouse studies, whileBacillus vallismortisandBacillus amyloliquefacienswere effectivein vitrobut notin vivo. Specifically,Bacillus thuringiensiswas observed to both hinder the growth ofPhytophthora capsiciand enhance plant resilience to this oomycete pathogen. To probe the molecular interactions between biocontrol agent and pathogen, a dual culture ofBacillus thuringiensisandPhytophthora capsiciwas analyzedin situusing a mass spectrometry imaging workflow that implemented desorption electrospray ionization. This imaging approach spatially investigated the complex biochemical interactions that serve as the molecular foundation for the effectiveness of these biological control agents in crop protection, including antagonistic interactions that may be fundamental to their method of action. Herein, we demonstrate the benefits of biological control agent application in tomato cultivation, including enhanced pathogen control and plant growth, and showcase the strengths of desorption electrospray ionization-mass spectrometry imaging when applied to the spatially-resolved molecular characterization of agriculturally relevant microorganisms.
The role of Dark Triad personality traits in consumers’ counterfeit luxury consumption: a moderated mediation model
Authors: Koay Kian Yeik , Lok Yan Yii 
Published: December 2024

PurposeThe purpose of this research is to examine the influence of the Dark Triad personality traits (Machiavellianism, narcissism and psychopathy) on consumers’ purchase intentions for counterfeit luxury products via the mediating effect of moral disengagement, drawing on moral disengagement theory. Furthermore, descriptive norms are tested as a moderators of the mediated relationships between the Dark Triad personality traits and purchase intentions via moral disengagement based on trait activation theory.Design/methodology/approachTo test the hypotheses, a survey design is employed to gather primary data from 205 consumers. The final data are analysed using partial least squares structural equation modelling.FindingsThis study finds that moral disengagement mediates the relationships between (1) Machiavellianism, (2) psychopathy and purchase intentions. Descriptive norms are found to moderate the indirect effect of moral disengagement between psychopathy and purchase intentions.Originality/valueDark Triad personality traits are linked to various unethical behaviours. However, no studies have explored how Dark Triad personality traits influence consumers’ purchase intentions for counterfeit luxury products. This study sheds light on how consumers with high Dark Triad personality traits are more likely to be morally disengaged, thereby leading to purchase intentions for counterfeit luxury products, drawing on moral disengagement theory. Furthermore, this study demonstrates descriptive norms as the boundary condition for the mediating relationship between Dark Triad personality traits and purchase intentions via moral disengagement, drawing on trait activation theory. The findings can be used to formulate better strategies to counteract the phenomenon of counterfeit luxury consumption.
Unlearning the past, relearning for tomorrow — a Gen Z perspective
Authors: S. Raksithaa 
Published: December 2024

Purpose
This paper explores the importance of Generation Z equipping organizational resilience through unlearning and relearning workplace behaviors. Through this, the paper will address how such adaptive strategies foster Gen Z employees’ ability to stay fresh and effective under dynamic and ever-changing environments and boost innovation and overall workplace productivity.

Design/methodology/approach
This paper offers the author’s viewpoint based on their experience in an organization-based setup and its impact on Gen Zers behavior; unlearn and relearn the workplace-based behavior.

Findings
The resilience of Gen Z is made possible through the ability of the generation to unlearn outdated practices and embrace continuous learning in their life. Such behavior would enhance organizational success by increasing adaptability, engagement, and innovation, especially in workplaces.

Originality/value
This study sheds light on how Generation Z could leverage unlearning and relearning to create organizational resilience. This study bridges the gap between the studies concerning generational behavioral patterns and, thus, brings to light the concept of continuous behavioral adaptation in the modern workplace.
Navigating sociopolitical waters: exploring the influence of key factors on global supply base concentration
Authors: Paulraj Antony , Datar Aneesh , Nakamura Azusa , Seepana Chandrasekararao 
Published: December 2024

PurposeVarious economic, strategic and sociopolitical factors drive the decisions related to the location of global supply chain partners. Yet, research on how sociopolitical factors affect these decisions is not that prevalent. We contribute to this line of research by evaluating the changes in global supply base concentration accounted for by three key sociopolitical factors – populism, state fragility and political constraints – that magnify or attenuate the effects of institutional risks, uncertainties and volatility.Design/methodology/approachApart from hypothesizing the negative effects of populism and state fragility, political constraints are conjectured to significantly attenuate these negative effects. The proposed hypotheses were motivated using the tenets of institutional economics theory and tested using a comprehensive dataset compiled from six widely used secondary data sources. The panel data spanning 2003–2018 focused on a sample of global US-listed companies with worldwide suppliers.FindingsOur results supported three of the four hypotheses. Specifically, the direct effects of populism and state fragility were found to be significant, suggesting that they reduced the number of suppliers in the country. However, political constraints did not moderate the effect of populism on global supply base concentration, while they negatively moderated the effect of the state fragility index. This result showcases the overpowering effect of populism on a country’s market environment.Originality/valueSupply chain scholars resoundingly acknowledge the need for more research on the effect of broader sociopolitical factors on global supply chain management. Responding to this call, we evaluate the direct and contingent effects of populism, state fragility and political constraints on global supply base concentration. Our choice of these factors was based on their representation of most of the critical institutional environments prevalent in various countries. One surprising result we found was that populism was found to be pervasive even in countries with strong checks and balances, suggesting its paramount importance to practicing management. Overall, by unraveling the interesting effects of these multidimensional sociopolitical factors, our study makes a valuable contribution to not only theory but also practice.
The impact of manager conservatism on innovation and capital expenditures: the role of the crisis caused by the covid-19 outbreak
Authors: Arianpoor Arash , Toorchi Mahsa 
Published: December 2024

Purpose
The present study aims to investigate the impact of manager conservatism on innovation and capital expenditures especially the moderating role of the crisis caused by the COVID-19 outbreak for companies listed on the Tehran Stock Exchange (TSE).

Design/methodology/approach
The present study investigated information about 178 companies in 2014–2022. In this study, the CEO’s signature was a psychological proxy of conservatism. Modified multiple regression analysis was used to investigate the moderating role of COVID-19. The present study also used the Generalized Method of Moments (GMM) to address endogeneity issues.

Findings
The results showed that manager conservatism has a positive and significant effect on capital expenditures, while manager conservatism negatively impacts firm innovation. In addition, COVID-19 significantly strengthens the impact of manager conservatism on capital expenditures and firm innovation. Hypothesis testing based on robustness checks confirmed these results.

Originality/value
This study aims to investigate the impact of manager conservatism, as a personality trait, on capital expenditures and innovation. These aspects have not been thoroughly explored in the existing literature. Additionally, it is important to consider the perceived threat of COVID-19, known to have a greater effect on conservatives. This study seeks to examine the interactive role of manager conservatism and COVID-19 on investment in capital expenditures and innovation. The present findings will not only benefit managers and policymakers in both developing and developed countries but will also provide valuable insights into decision-making processes related to capital expenditures and innovation during critical conditions such as the COVID-19 outbreak.
Art of developing a vision for integrated healthcare and social services: an interview study with stakeholders in Sweden
Authors: Strömqvist Bååthe Karin , Aytar Osman , von Thiele Schwarz Ulrica , Arkkukangas Marina 
Published: December 2024

PurposeTo gain a deeper understanding of the development of a joint vision for Close Care, its obstacles and opportunities, in the region of Sörmland based on national health and social services reforms.Design/methodology/approachSeven semi-structured interviews were conducted with thirteen stakeholders. Documentation from the process was used to enhance the findings. A qualitative content analysis was performed.FindingsStakeholders described Close Care as entailing “person centeredness, cooperation, and resource sharing” but found it “too abstract”. Participation in developing the vision varied, with experiences of “external pressure” and low “readiness for organisational change”. Views on a regional vision’s “relevance and usability” differed. Participants highlighted several opportunities for the Close Care vision, such as: “a stepping-stone for implementation”, “harmonises with other health care visions” and “forming a cross municipal and regional network”. They also noted obstacles like “symbolic alienation”, “cognitive complexity”, “short-term economic reality” and “uncertainty around implementation”.Practical implicationsOpportunities and obstacles for the vision of Close Care can inform complex healthcare reforms that require stakeholder cooperation.Social implicationsUnderstanding Close Care may enable health system stakeholders to more effectively cooperate around the citizens’ needs.Originality/valueResearch on common ground has mainly focused on national or international policy levels and individual hospitals, professionals or patients. This study offers insights on regional and municipal cooperation in health care driven by a common vision.
AI adoption: a bridge or a barrier? The moderating role of organizational support in the path toward employee well-being
Authors: Soomro Sanam , Fan Mingyue , Sohu Jan Muhammad , Soomro Safia , Shaikh Sonia Najam 
Published: December 2024

PurposeThe purpose of this study is to assess how managerial capability affects artificial intelligence (AI) adoption and employee well-being now in a dynamic context of organizational change. This study investigated the role that managerial capability and organizational support play in facilitating successful AI technology implementation within organizations. The study seeks to provide an integrated perspective on how organizations can help mitigate the effects of AI anxiety and improve the well-being of employees.Design/methodology/approachA survey questionnaire was administered to collect data from 324 employees and managers working in small- and medium-sized enterprises (SMEs) located in Pakistan. Partial least squares-structural equation modeling (PLS-SEM) was employed using Smart PLS version 4.1.0.3 to analyze the relationships between the study variables.FindingsThe findings of the study show that AI anxiety can significantly impact employee well-being. However, the relationship was moderated by organizational support. When organizational support was high, the effects of AI anxiety decline on employee well-being.Originality/valueThis study offers three important implications; it adds to our understanding regarding AI adoption and its effect on employee well-being by addressing how managerial interventions may facilitate the smooth integration of AI technology and examining the moderating effect that organizational support might have over the association between anxiety and employee well-being. Additionally, we have offered a nuanced view of the potential impact of AI adoption on employees and offered practical recommendations for organizations to undertake to address AI anxiety and promote employee well-being during AI implementation.
Advanced trading strategies based on the sobering-up effect
Authors: Ho Chun-Ching , Jang Woan-yuh 
Published: December 2024

PurposeThis study investigates analysts’ sobering-up effect on future stock returns and further verifies whether analysts’ familiarity with the forecasted firms and market sentiment affect the relationship between the magnitude of the sobering-up effect on analysts’ earnings forecasts and long-term future stock performance.Design/methodology/approachUsing stocks listed on the Taiwan Stock Exchange (TWSE) and the Taipei Exchange (TPEx) from 2000 to 2021, we propose a trading sobering-up strategy which involves taking a long position in the portfolio with a smaller magnitude of the sobering-up effect and a short position in the portfolio with a greater magnitude of the sobering-up effect.FindingsWe find that an advanced trading strategy which involves taking a long (short) position in the portfolio with a smaller (greater) magnitude of sobering-up effect during the bullish market period, is superior to the sobering-up trading strategy as well as the sobering-up plus familiarity trading strategy and can generate a significantly positive long-term abnormal stock return.Originality/valueThis study explores the dynamic psychological factors behind the magnitude of the sobering-up effect on analysts’ earnings forecasts’ influences. Employing familiarity and market sentiment verify the relationship between the magnitude of the sobering-up effect on analysts’ earnings forecasts and future stock returns. The results give a reference for investors when investing and offer the potential investors significant trading gains.
A holistic review of customer experience research: topic modelling using BERTopic
Authors: Mishra Manit 
Published: December 2024

PurposeThis study consolidates the current state of knowledge in customer experience (CX) research by examining literature published over last 20 years (2003–2022). The purpose is to create a holistic snapshot through synthesis of extant CX research; and thereafter, leverage the snapshot to generate directions for future inquiry.Design/methodology/approachThe study uses systematic literature review (SLR) using SPAR-4-SLR protocol to generate a set of 277 articles. We follow it up with scientometric analysis techniques of bibliographic coupling and betweenness centrality measurement. Finally, to extract topics from the full-text content of sampled articles, we carry out topic modelling using BERTopic.FindingsThe study unearths following insights: (1) the predominant underlying topics in extant CX research are: service experience, store brand marketing, mall and online shopping, fun and luxury marketing, brand equity and loyalty artificial intelligence (AI) and machine learning (ML) and augmented reality (AR) and virtual reality (VR); (2) bibliographic coupling suggests existence of six clusters in CX research. The study also showcases the nucleus of CX research, flagship research, major publication outlets and representative studies for each extracted topic.Research limitations/implicationsThe paper introduces BERTopic to marketing scholars as a novel method of executing topic modelling and thereby, unearthing latent insights.Originality/valueThe study expands the body of knowledge on CX by applying three complementary analytical approaches: SLR, scientometric analysis and topic modelling using BERTopic.
Don’t overdo it with blockchain – understanding the impact of blockchain on users’ security perception
Authors: Jha Abhishek Kumar , Kumar Saurabh , Jain Aarushi 
Published: December 2024

PurposeBlockchain technology has been labeled as the most disruptive technological innovation of the current decade due to its impact on almost every major industry. Based on privacy calculus theory and prior adoption literature on emerging technologies, this research investigates the impact of blockchain technology in the consumer technology segment. It elaborated on the mechanism through which blockchain technology influences users’ willingness to share information with technology products enabled by blockchain.Design/methodology/approachTaking a heterogeneous pool of users, this study conducted multiple experiments with the application of blockchain (vs. regular database) technology to high (vs. low) sensitive data to study the impact of blockchain perception on users’ information-sharing tendencies.FindingsThrough a mediated moderation analysis, the result shows that the use of blockchain technology enhances the sense of security among users. However, the impact of this heightened sense of security only develops a higher willingness to share information when the data is highly sensitive.Practical implicationsThe research reflects on the perception of blockchain technology and the leading impact on willingness to share information with firms. This could be a critical criterion for determining investment in blockchain technologies for consumer products, particularly based on the sensitivity of the data the consumer is sharing.Originality/valueThis research focuses on the perception of blockchain technology among consumers and its impact on consumers’ decision-making related to their data sharing. People have a higher sense of safety when it comes to blockchain-enabled products. However, we find that it would not be the same for all contexts, and the sensitivity of the data collected would have an impact on this relationship and consumers’ data-sharing decisions.
Fingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub‐G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo
Authors: Pournajaf Safura , Afsordeh Nastaran , Bayat Hadi , Pourgholami Mohammad Hossein 
Published: December 2024

ABSTRACTGlioblastoma multiforme (GBM), the most prevalent brain tumour, is universally fatal. GBM cells exhibit cell cycle disruption and treatment resistance, remarking an urgent need for newer treatments. Fingolimod, a sphingosine‐1‐phosphate receptor modulator, has been reported to have anti‐cancer effects. This study investigated the therapeutic potentials of fingolimod in rat C6 cells and pursued the involved mechanism(s). Cell survival, proliferation, migration, and morphology of fingolimod‐treated C6 cells were evaluated using MTT, soft‐agar colony formation, wound‐healing, and Giemsa staining assays. Apoptosis was investigated through acridine orange/ethidium bromide (AO/EB) and annexin V staining, and flow cytometry analysed the cell cycle. Quantitative reverse transcription PCR and western blotting were used to evaluate gene and protein expressions. An intracranial C6 rat model validated the anti‐tumour effect of fingolimod. Fingolimod significantly reduced the survival and colonies of the C6 cells and delayed their gap closure. Cell shrinkage coupled with AO/EB and PI staining of the fingolimod‐treated cells indicated apoptosis, subsequently confirmed by measuring the expression levels of the candidate genes involved in apoptosis and cell cycle, such as Bax/Bcl2, P53, Cytochrome C and Caspases 9/3, Fas, Fadd, Tnfrsf1a, Cdkn1a, and Ccnd1, at RNA and protein levels, indicating both extrinsic and mitochondrial apoptosis and cell cycle arrest at sub‐G1 phase in fingolimod‐treated cells. Furthermore, treating rats bearing intracranial C6 tumours with fingolimod led to significant suppression of intracranial tumour growth. Based on our findings, cell cycle arrest and apoptosis contribute to fingolimod antitumor effects.