bluuebunny/crossref_metadata_2025_split huggingface dataset:
DOZ047.93: Thoracoscopic multistage repair of long-gap esophageal atresia using internal traction suture technique—evolution of the method
Authors: Patkowski D , Gerus S , Rasiewicz M 
Published: June 2019

Abstract

Treatment of long-gap esophageal atresia poses a great challenge for a surgeon. A new multistage thoracoscopic repair of long-gap esophageal atresia using internal traction technique was developed that evolved with time and growing experience. The goal of this study is to present the changes in the strategy and important technical aspects of the operative method based on a retrospective analysis of performed surgeries.

Methods and Materials
Thirty-five cases of newborns with long-gap esophageal atresia (type A-26 cases and B-9 cases exclusively) were operated thoracoscopically between 2008 and 2019 using internal traction technique in different pediatric surgery centers (Poland–28, Czech–1, Ukraine–1, Switzerland–2, Egypt–2, Russia–1). The idea of the internal traction technique was to place the suture between thoracoscopically mobilized esophageal pouches and keep a static tension between them for a period of time. Patients were operated on as early as it was possible after birth.

Results
Of the 35 newborns operated on using internal traction 2 patients died before the final stage from not surgically-related causes. Two patients had complications that required neck fistula and had later Collis–Nissen and colon interposition, respectively. One case is awaiting the final procedure. For 31 cases the final esophageal anastomosis was completed in two stages–16 cases, three stages–9, four stages–2, five stages–2, and six stages–1. At the beginning the time between stages was planned for 4 weeks (for some cases it was even longer) and it was shortened for the last three cases to 5 days. It allowed avoiding gastrostomy in two cases. The internal traction was modified from using two traction loops to one traction loop with two slipping knots on each branch of the loop. The clips were applied transversely through the tip of each pouch and part of the traction loop to prevent disruption and pouch perforation. It also allowed increasing of the created static traction force.

Conclusion
Results of the study may indicate that in a majority of long-gap esophageal atresia it is possible to preserve the native esophagus by a thoracoscopic approach using an internal traction suture technique. Shortened time between stages allowed completion of the final esophageal anastomosis with gastrostomy avoidance.
DOZ047.97: Anastomotic strictures in patients with oesophageal atresia systematically treated with PPI: prospective cohort study over 10 years
Authors: Grunder F R , Petit L M , Ezri J , Jantchou P , Aspirot A , Faure C 
Published: June 2019

Abstract

Objectives and Study
Clinical course in oesophageal atresia (OA) patients is frequently complicated by gastroesophageal reflux disease, which is thought to be a risk factor for formation of anastomotic strictures. It is currently recommended that OA patients be treated systematically with proton pump inhibitors (PPI) after surgical repair. However, it is not clear if PPI treatment does really prevent the formation of anastomotic strictures and reduce the incidence of histological complications during long-term follow up. This study aimed to describe the outcomes of a cohort of OA patients with or without tracheoesophageal fistula (TOF) systematically treated with PPI since the neonatal period.

Method
Prospective longitudinal cohort study over 11 years of 73 children with OA-TOF, systematically treated with PPI, was carried out. Descriptive data is presented as median (interquartiles) for continuous variables and as frequency (%) for categorical variables. Pearson's χ2 test, Fisher's exact test, and Wilcoxon rank sum test were used for univariate analysis. SAS software, version 9.3 (SAS Institute, Cary, NC) was used; P-values < 0.05 were considered statistically significant.

Results
Seventy-three patients (41 males) were included in the final analysis. The median age at study completion was 4.87 years (3.64, 7.97; range 1–11.4). According to Gross classification, 64 patients (88%) had OA type C, 8 (11%) had type A, and 1 (1%) had type D; long-gap OA was present in 16 patients (22%). Thoracotomy was performed in 56 patients and thoracoscopy in 17. Anastomotic strictures and recurrent strictures were diagnosed in 32 (44%) and 17 patients (23%), respectively. In all but one case, strictures occurred when the child was on PPI. Anastomotic strictures occurred significantly more frequently in long-gap OA, in patients with anastomotic leak after surgical repair and longer hospital stay (P = 0.02, 0.002, and 0.02 respectively). Histological complications, especially gastric metaplasia, appeared more frequently in OA patients with anastomotic strictures (P = 0.01).

Conclusion
Forty-two percent of patients developed anastomotic strictures on PPI treatment, therefrom 55% patients with recurrent anastomotic strictures, indicating that acid gastroesophageal reflux seems not to be the major trigger factor for developing anastomotic strictures. A more selective prescription of PPI should be discussed.
Transfer 2.0: Applying the Concept of Transfer from Track-Two Workshops to Inclusive Peace Negotiations
Authors: Cuhadar Esra , Paffenholz Thania 
Published: June 2019

AbstractThis article argues that the scholarly study of “transfer” from track-two workshops to track-one negotiations is highly applicable to the study of transfer from other modalities of participation to track-one in inclusive peace negotiations. During the last decade, other approaches to make negotiations more inclusive have also been increasingly employed, such as national dialogue conferences, variety of consultation mechanisms, or a diverse set of peace commissions. In this paper, we aim to expand the conceptualization of transfer beyond ICR workshops and discuss how the knowledge accumulated concerning transfer in the ICR literature during the last decades can be applied to understand and evaluate transfer from other inclusion modalities used in peace negotiations today. We therefore make a distinction between the first generation of transfer (1.0) developed by the ICR workshops scholars and practitioners and the transfer process from other modalities used in inclusive negotiations (2.0). To apply the lessons learned from transfer 1.0 to 2.0, we start with an overview of the concept as developed in track-two literature. We then suggest a conceptualization of transfer 2.0, based on insights from how it has unfolded in five of the seven inclusion modalities examined in our comparative case study. We discuss the similarities and differences between transfer 1.0 and 2.0 and how transfer 2.0 can be studied, including and beyond track-two initiatives. We conclude by suggesting a number of directions for future research on transfer 2.0 that are relevant to several inclusion modalities.
Calves, as a model for juvenile horses, need only one sprint per week to experience increased bone strength
Authors: Logan Alyssa A , Nielsen Brian D , Robison Cara I , Manfredi Jane M , Buskirk Daniel D , Schott Harold C , Hiney Kristina M 
Published: June 2019

AbstractPrevious research has determined that maintaining young animals in stalls is detrimental to their bone health, while the addition of 50 to 82-m sprints 5 d/week aids in counteracting the reduction of bone strength from confinement. The current research aims to determine if 1 or 3 d/week of sprinting affords the same benefits to bone as 5 d/week of sprinting compared to animals confined with no sprinting. Twenty-four Holstein bull calves were obtained from the Michigan State University Dairy Cattle Teaching and Research Center. At 9 wk of age, calves were randomly assigned to treatments of 1, 3, or 5 d/week of sprint exercise, or to the confined control group sprinted 0 d/week. Each treatment had 6 calves. Individual sprinting bouts included a single sprint down a 71-m concrete aisle. For the duration of the 6-wk study, calves were housed at the MSU Beef Cattle Teaching and Research Center in stalls which afforded calves room to stand, lay down, and turn around. Serum was collected weekly via jugular venipuncture to obtain concentrations of osteocalcin (OC) and C-telopeptide crosslaps of type I collagen (CTX-1)—markers of bone formation and degradation, respectively. Sprints were videotaped weekly to determine stride frequency and sprint velocity. On day 42, calves were humanely euthanized at the Michigan State University Meat Lab and both front limbs were immediately harvested. Computed tomography scans and mechanical testing were performed on the left fused third and fourth metacarpal bones. Serum OC concentration was greatest for calves sprinted 5 d/week (P < 0.001). Calves sprinted 5 d/week had both greater stride frequency (P < 0.05) and lower sprint velocity (P < 0.05). All exercise treatments experienced greater dorsal cortical widths compared to control animals (P < 0.01). Through mechanical testing, fracture forces of all sprinting treatments were determined to be greater than the control treatment (P < 0.02). Results from this study support that sprinting 1, 3, or 5 d/week during growth can increase bone health and cause favorable alterations in bone markers. While all exercise treatments had over a 20% increase to fracture force, calves sprinted 1 d/week sprinted only 426 m over the 6-wk study and still experienced over a 20% increase in bone strength compared to confined calves. This study demonstrates the remarkably few strides at speed needed to enhance bone strength and emphasizes the danger to skeletal strength if sprinting opportunities are not afforded.
Perceived Value of a Knowledge Translation Intervention Designed to Facilitate Burn Survivors’ Work Reintegration
Authors: Lamble Melissa , Seto Vanessa , Ye Zi , Couture Charlotte , de Oliveira Ana , Calva Valerie , Couture Marie-Andrée , Poulin Chantal , LaSalle Léo , Nedelec Bernadette 
Published: June 2019

Abstract
Returning to work can be challenging for burn survivors. Approximately 28% never return to any form of employment, resulting in lower health-related quality of life. Open communication has been identified as a facilitator for return to work (RTW). To ease the RTW process and promote communication with coworkers and employers a knowledge translation (KT) intervention was developed for burn survivors. Following its implementation, the impact on the RTW process was evaluated. This study was a cross-sectional, mixed methods study where burn survivors included in the KT intervention were compared with a control group. Control group participants were selectively invited so that the two groups’ mean age, sex, and percent total body surface area burned were similar. Semistructured interviews gathered information about their RTW process and outcomes. Qualitative data were analyzed through thematic analysis and quantitative data were summarized and compared using Mann–Whitney tests. Overall, both groups were satisfied with their RTW process. Participants from the control group identified more barriers related to support received, particularly at work, and reported more psychological symptoms such as posttraumatic stress disorder, self-consciousness, and discomfort with questions. Many participants from the KT group indicated the KT intervention gave them tools and information to provide others with a better understanding of their lived experience. It is possible that the KT intervention facilitated more open communication by empowering burn survivors to explain their situation on their own, thus reducing the prevalence of social and psychological barriers by allowing them to self-advocate for more support.
Determinism, Counterpredictive Devices, and the Impossibility of Laplacean Intelligences
Authors: Ismael Jenann 
Published: June 2019

Abstract
In a famous passage drawing implications from determinism, Laplace introduced the image an intelligence who knew the positions and momenta of all of the particles of which the universe is composed, and asserted that in a deterministic universe such an intelligence would be able to predict everything that happens over its entire history. It is not, however, difficult to establish the physical possibility of a counterpredictive device, i.e., a device designed to act counter to any revealed prediction of its behavior. What would happen if a Laplacean intelligence were put into communication with such a device and forced to reveal its prediction of what the device would do on some occasion? On the one hand, it seems that the Laplacean Intelligence should be able to predict the device's behavior. On the other hand, it seems like that device should be able to act counter to the prediction. An examination of the puzzle leads to clarification of what determinism does (and does not) entail, with some insights about various other things along the way.
A Case Series of Double Bypass Technique Used for the Treatment of Internal Carotid Blood Blister-like Aneurysms in Patients in Poor Initial Neurological Condition at the Early Stage of Subarachnoid Hemorrhage
Authors: Balik Vladimir , Takebayashi Seiji , Takizawa Katsumi 
Published: June 2019

Abstract

BACKGROUND
Optimal surgical treatment of blood-blister aneurysms (BBA) remains controversial. Some surgeons prefer clipping reconstruction while others favor primary bypass with trapping.

OBJECTIVE
To analyze of benefit of double bypass technique to surgical outcomes in patients with ruptured BBA in poor initial neurological condition (PINC).

METHODS
Retrospective analysis of clinical, radiological, and surgical data in 9 patients treated between January 2009 and December 2015. Intraoperative middle cerebral artery blood pressure (MCABP) measurement was used for selection of bypass procedure.

RESULTS
Seven patients presented with World Federation of Neurosurgical Societies (WFNS) subarachnoid hemorrhage (SAH) score 4 or 5. No pulse pressure in the MCA after internal carotid artery (ICA) clamping was found in 3 patients, although their ACoA or PCoA were well visualized on preoperative angiograms. By contrast, only a minimal drop in MCABP following ICA clamping was detected in two cases, although their collaterals were slim/nonvisualized on imaging. Although angiographic vasospasms were not observed in our patients, two of them experienced cerebral infarction, attributable more to the mass effect and postoperative ICA thrombosis than to SAH-induced vasospasm. There were 2 premature intraoperative ruptures, but no perioperative mortality, aneurysm recurrence, or rebleeding. Five patients with WFNS SAH score 4 or 5 achieved favorable outcomes.

CONCLUSION
Early double bypass technique guided by MCABP measurement and combined with trapping (or rarely clipping) seems to be a safe method with excellent long-term outcomes in patients in PINC. This study may thus contribute to the debate on the optimal treatment strategy for BBA.
Surgical Treatment of Flat Back Syndrome With Anterior Hyperlordotic Cages
Authors: Janjua M Burhan , Ozturk Ali K , Ackshota Nissim , McShane Brendan J , Saifi Comron , Welch William C , Arlet Vincent 
Published: June 2019

Abstract

BACKGROUND
Traditional correction for flat back syndrome is performed with a posterior-based surgery or combined approaches in revision cases.

OBJECTIVE
To evaluate outcome from anterior surgery with the use of hyperlordotic cages (HLCs) in patients with flat back syndrome.

METHODS
All patients operated with or without prior posterior lumbar surgery were studied. Pre- to postoperative sagittal alignment was analyzed. Radiographic parameters were analyzed including T1 pelvic angle (T1PA), sagittal vertical axis (SVA), pelvic tilt (PT), pelvic incidence (PI), lumbar lordosis (LL), sacral slope (SS), pelvic incidence and lumbar lordosis (PI-LL), and T4-12TK.

RESULTS
All 50 patients (mean age of 58 yr, 72% female with mean body mass index of 28) demonstrated significant radiographic alignment difference in their spinopelvic and global parameters from pre- to postoperative standing: LL (–37.04° vs –59.55°, P < .001), SS (35.12 vs 41.13, P < .001), PI-LL (23.55 vs 6.46), T4-12 TK (30.59 vs 41.67), PT (28.22 vs 22.13), SVA in mm (80.94 vs 37.39), and T1PA (28.70° vs 18.43°, P < .001). Using linear regression analysis, predicted pre- to postoperative change in standing LL corresponded to a pre- to postoperative changes in standing PI-LL mismatch, T1PA, TK, SS, PT, and SVA (R2 = 0.59, 0.38, 0.25, 0.16, 0.12, and 0.17, respectively). Five degrees of pre- to postoperative change in T1PA translates to –4.15° change in LL.

CONCLUSION
Anterior surgery with HLCs followed by posterior instrumentation is an effective technique to treat flat back syndrome. HLCs are effective to maximize LL up to 30°, which is equivalent in magnitude to a pedicle subtraction osteotomy, but associated with less blood loss, quicker recovery, lower complications, and good surgical outcome.
High-Resolution O-Arm Data Reconstruction for Optimized Intraoperative Imaging of Deep Brain Stimulation Leads: A Preclinical Study
Authors: Hunsche Stefan , Maarouf Mohammad , Neudorfer Clemens 
Published: June 2019

Abstract

BACKGROUND
The employment of the O-arm for intraoperative localization of deep brain stimulation (DBS) leads has been shown to be feasible and effective. However, partial volume artifacts impede the determination of individual electrode contacts and thus allow only an indirect approximation of each contact's localization.

OBJECTIVE
To reduce the partial volume artifacts by means of high-resolution (HiRes) reconstruction of O-arm data and thus allow more accurate predictions with regard to the positioning and orientation of individual DBS contacts.

METHODS
Following intraoperative flat-panel computed tomography, the O-arm raw data were reconstructed with a resolution of 0.2 mm × 0.2 mm × 0.2 mm. The geometric integrity of HiRes reconstructions was assessed via landmark transformation. Using a phantom, resolutions of both reconstruction modalities were then evaluated by means of the modulation transfer function (MTF). Finally, directional and nondirectional leads were compared visually to analyze the delineation of individual electrode contacts.

RESULTS
With a mean accuracy of 0.56 mm ± 0.12 mm, geometric integrity remained intact during HiRes reconstruction. Analysis of HiRes reconstruction resolution yielded a 47.7% increase of the 10% MTF in comparison to conventional postprocessing. Reduction of partial volume artifacts yielded strong contrasts of electrode compartments and allowed direct identification of individual contacts as well as localization of the X-ray marker on directional leads.

CONCLUSION
HiRes reconstruction of O-arm data allows an effective reduction of partial volume artifacts to such an extent that a delineation of individual contacts across single DBS leads is possible without requiring increases in radiation dose.
Addressing tobacco smoking and drinking to improve TB treatment outcomes, in South Africa: a feasibility study of the ProLife program
Authors: Louwagie Goedele M , Morojele Neo , Siddiqi Kamran , Mdege Noreen D , Tumbo John , Omole Olu , Pitso Lerato , Bachmann Max O , Ayo-Yusuf Olalekan A 
Published: June 2019

Abstract
Alcohol and tobacco use may lead to negative treatment outcomes in tuberculosis (TB) patients, and even more so if they are HIV-infected. We developed and tested the feasibility of a complex behavioral intervention (ProLife) delivered by lay health workers (LHWs) to improve treatment outcomes in TB patients who smoke tobacco and/or drink alcohol, at nine clinics in South Africa. The intervention comprised three brief motivational interviewing (MI) sessions augmented with a short message service (SMS) program, targeting as appropriate: tobacco smoking, harmful or hazardous drinking and medication adherence. Patients received SMSs twice a week. We measured recruitment and retention rates and assessed fidelity to the MI technique (MI Treatment Integrity 4.1 tool). Finally, we explored LHWs’ and patients’ experiences through interviews and semi-structured questionnaires, respectively. We screened 137 TB patients and identified 14 smokers, 13 alcohol drinkers, and 18 patients with both behaviors. Participants’ mean age was 39.8 years, and 82.2% were men. The fidelity assessments pointed to the LHWs’ successful application of key MI skills, but failure to reach MI competency thresholds. Nevertheless, most patients rated the MI sessions as helpful, ascribed positive attributes to their counselors, and reported behavioral changes. SMSs were perceived as reinforcing but difficult language and technical delivery problems were identified as problems. The LHWs’ interview responses suggested that they (a) grasped the basic MI spirit but failed to understand specific MI techniques due to insufficient training practice; (b) perceived ProLife as having benefitted the patients (as well as themselves); (c) viewed the SMSs favorably; but (d) considered limited space and privacy at the clinics as key challenges. The ProLife program targeting multiple risk behaviors in TB patients is acceptable but LHW training protocol, and changes in wording and delivery of SMS are necessary to improve the intervention.
Trial registration: ISRCTN14213432
Betatron radiation and emittance growth in plasma wakefield accelerators
Authors: San Miguel Claveria P. , Adli E. , Amorim L. D. , An W. , Clayton C. E. , Corde S. , Gessner S. , Hogan M. J. , Joshi C. , Kononenko O. , Litos M. , Lu W. , Marsh K. A. , Mori W. B. , O'Shea B. , Raj G. , Storey D. , Vafaei-Najafabadi N. , White G. , Xu Xinlu , Yakimenko V. 
Published: June 2019

Beam-driven plasma wakefield acceleration (PWFA) has demonstrated significant progress during the past two decades of research. The new Facility for Advanced Accelerator Experimental Tests (FACET) II, currently under construction, will provide 10 GeV electron beams with unprecedented parameters for the next generation of PWFA experiments. In the context of the FACET II facility, we present simulation results on expected betatron radiation and its potential application to diagnose emittance preservation and hosing instability in the upcoming PWFA experiments.
This article is part of the Theo Murphy meeting issue ‘Directions in particle beam-driven plasma wakefield acceleration’.
Advanced schemes for underdense plasma photocathode wakefield accelerators: pathways towards ultrahigh brightness electron beams
Authors: Manahan G. G. , Habib A. F. , Scherkl P. , Ullmann D. , Beaton A. , Sutherland A. , Kirwan G. , Delinikolas P. , Heinemann T. , Altuijri R. , Knetsch A. , Karger O. , Cook N. M. , Bruhwiler D. L. , Sheng Z.-M. , Rosenzweig J. B. , Hidding B. 
Published: June 2019

The ‘Trojan Horse’ underdense plasma photocathode scheme applied to electron beam-driven plasma wakefield acceleration has opened up a path which promises high controllability and tunability and to reach extremely good quality as regards emittance and five-dimensional beam brightness. This combination has the potential to improve the state-of-the-art in accelerator technology significantly. In this paper, we review the basic concepts of the Trojan Horse scheme and present advanced methods for tailoring both the injector laser pulses and the witness electron bunches and combine them with the Trojan Horse scheme. These new approaches will further enhance the beam qualities, such as transverse emittance and longitudinal energy spread, and may allow, for the first time, to produce ultrahigh six-dimensional brightness electron bunches, which is a necessary requirement for driving advanced radiation sources.
This article is part of the Theo Murphy meeting issue ‘Directions in particle beam-driven plasma wakefield acceleration’.