bluuebunny/crossref_metadata_2025_split huggingface dataset:
Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG proteins in the heart
Authors: Jones David K. , Johnson Ashley C. , Roti Roti Elon C. , Liu Fang , Uelmen Rebecca , Ayers Rebecca A. , Baczko Istvan , Tester David J. , Ackerman Michael J. , Trudeau Matthew C. , Robertson Gail A. 
Published: March 2018

ABSTRACT
Reduced levels of the cardiac human (h)ERG ion channel protein and the corresponding repolarizing current IKr can cause arrhythmia and sudden cardiac death, but the underlying cellular mechanisms controlling hERG surface expression are not well understood. Here, we identified TRIOBP-1, an F-actin-binding protein previously associated with actin polymerization, as a putative hERG-interacting protein in a yeast-two hybrid screen of a cardiac library. We corroborated this interaction by performing Förster resonance energy transfer (FRET) in HEK293 cells and co-immunoprecipitation in HEK293 cells and native cardiac tissue. TRIOBP-1 overexpression reduced hERG surface expression and current density, whereas reducing TRIOBP-1 expression via shRNA knockdown resulted in increased hERG protein levels. Immunolabeling in rat cardiomyocytes showed that native TRIOBP-1 colocalized predominantly with myosin-binding protein C and secondarily with rat ERG. In human stem cell-derived cardiomyocytes, TRIOBP-1 overexpression caused intracellular co-sequestration of hERG signal, reduced native IKr and disrupted action potential repolarization. Ca2+ currents were also somewhat reduced and cell capacitance was increased. These findings establish that TRIOBP-1 interacts directly with hERG and can affect protein levels, IKr magnitude and cardiac membrane excitability.
Effectiveness of tomotherapy v
s linear accelerator image-guided intensity-modulated radiotherapy for localized pharyngeal cancer treated with definitive concurrent chemoradiotherapy: a Taiwanese population-based propensity score-matched analysis
Authors: Wang Yao-Ching , Li Chia‑Chin , Chien Chun-Ru 
Published: March 2018

Objective:
This study used a population-based propensity score (PS)-matched analysis to compare the effectiveness of tomotherapy-based image-guided intensity-modulated radiotherapy (referred to as T-IMRT) with that of linear accelerator based (referred to as L-IMRT) for clinically localized pharyngeal cancer (LPC, divided into nasopharyngeal cancer and non-nasopharyngeal cancer) with definitive concurrent chemoradiotherapy (CCRT).

Methods:
Eligible LPC patients diagnosed between 2007 and 2014 were identified among all citizens in Taiwan from the Health and Welfare Data Science Center database. A PS-matched sample based on the PS estimated from the covariables of interest was constructed to compare the effectiveness of T-IMRT with L-IMRT. In the primary analysis, overall survival (OS) was compared for assessment of effectiveness. We also evaluated freedom from local regional recurrence and pharyngeal cancer-specific survival and performed supplementary analyses.

Results:
The study population included 960 patients equally divided into two groups. OS did not differ significantly between the T-IMRT and L-IMRT groups (hazard ratio for death: 0.82, p = 0.15, 5-year OS rate: 79 and 74% for T-IMRT and L-IMRT, respectively), and there were no significant differences in the other endpoints or supplementary analyses.

Conclusion:
For LPC patients treated with definitive CCRT, we found no significant difference in disease control or survival between the T-IMRT and L-IMRT groups. However, further studies, especially randomized trials or studies focusing on other dimensions, such as quality of life, are needed.

Advances in knowledge:
We provide the first population-based study, as well as the largest study, on the clinical effectiveness of T-IMRT compared with L-IMRT in conjunction with CCRT in LPC patients.
Vascular malformations
Authors: Becker-Köhnlein J. , Poetke M. , Berlien H.-P. 
Published: March 2018

SummaryTogether with the vascular tumours the vascular malformations form the group of congenital vascular anomalies. However, they have to be clearly separated from each other in diagnosis. This is supported by the current ISSVAClassification, which recently included embryological aspects of the Hamburg Classification.
Model for de novo mutation propagation depending on paternal age at conception and associated neurological disorders
Authors: Lawen Johannes , Wang Ena 
Published: March 2018

This paper presents a computational model for simulating the propagation of de novo mutations and paternal age effects in populations. The model uses data for paternal de novo mutation rates depending on age and demographic data such as age distributions, birth distributions versus age, varying life expectancy, and correlations with fertility. The number of paternal de novo mutations in children increases with the paternal age at conception. This might be of interest considering that the average paternal age has risen significantly in many societies throughout the last century. The model introduced below can superimpose and extrapolate different effects based on demographic dynamics. This includes the assessment of statistically associated neurological disorders in offspring, particularly IQ decay depending on the paternal age and other medical phenotypes which constitute paternal age effects. Yearly paternal mutation rates and correlations with paternal age were used to simulate both, de novo mutation propagation and probabilities for correlating conditions such as IQ decay. The extrapolated effect after several generations of persistently elevated paternal age appears to be drastic. To account for possibly mitigating factors, the paternal age effect has been super-positioned with the Flynn effect in simulated cases. The model automatically generates distributions for varying paternal ages, not just single cases, in convenient 3D distributions. The model simulates each person’s individual reproductive incidents through a particle type approach which is more rigorous than insufficiently adaptive, continuum models based on partial differential equations. The model is not only applicable to humans and yields many valuable conclusions for a wide array of topics including the paternal age effect, correlations with intelligence, evolution, bottlenecks in evolution, as well as the role of de novo mutation.
Wybrane aspekty konwersji semantycznej – przypadek tolerancji
Authors: Stoiński Andrzej 
Published: March 2018

Selected Aspects of Semantic Conversion – The Case of Toleration
The text refers to the selected aspects of semantic conversion defined as the process of transformation of the meaning of the terms. This paper deals with the notion of “toleration”. The classic negative tolerance was described as a lack of intolerance. Otherwise, the positive tolerance is often characterized as acceptance, esteem, or affirmation for differences. Such distinction between them has the effect that in the face of the negative theory positive tolerance appears paradoxical. On the other hand, in perspective of the positive theory the classic idea seems to be intolerance. Basing on positive concept may lead to a reductionist alternative: acceptance (esteem, affirmation) – intolerance. In the article the Author also considers the problem of connections between toleration and the power of individual. Furthermore, the paper examines simple and complex objects of tolerance and the problem of the person as a subject of toleration.
Birthing modernity: The BBC’s Count Dracula (1977)
Authors: Hopkins Lisa 
Published: March 2018

Abstract
The BBC’s 1977 Count Dracula is cast firmly in the mould of a BBC classic serial, privileging fidelity, frocks and location shots. However, a surprising amount of cultural work is done by the adaptation’s few but striking deviations from its general principle of fidelity, such as the total omission of Arthur Holmwood, the turning of Lucy and Mina into sisters rather than friends and Dracula’s speech in defence of vampirism, coupled with the absence of any suggestion that vampirism might be a metaphor for something other than itself. This adaptation’s focus, I suggest, is to precipitate the arrival of modernity, as a half-glimpse of the Simone Martini Annunciation in the crypt of Carfax leads into Dracula materializing in Mina’s bedroom as white smoke like an Unholy Ghost, suggesting that a new era is about to dawn and that sexuality is out of the coffin in which the Victorians sought to imprison it.
Curating a fan history of vampires: ‘What We Vid in the Shadows’ at VidUKon 2016
Authors: Stevens E. Charlotte 
Published: March 2018

Abstract
At the 2016 fan convention VidUKon, I curated and screened a vidshow themed around vampires. A vidshow is a curated programme of fanvids, fan-made video art pieces that adapt television and film sources into short videos, which is shown at media fan conventions. To plan this, I first selected vampire-related examples from my research collection, and then drafted a list of screen vampires to guide my search for other vids to address gaps. From there, my curation was guided by a series of questions about how these pocket-sized adaptations would contribute to the vidshow’s representation of screen vampires. How do these act as a history of media fandom’s relationship with screen vampires? Vids are works of textual analysis that offer critical and creative responses to their source texts. What would my selection argue about how we watch vampires? I propose that vidshows are a site of negotiating fan-favourite and cult canons of vampire shows and characters.
Beware of polar nights: The vampire figure in Nordic cinematography
Authors: Wajda Piotr 
Published: March 2018

Abstract
This article aims to identify the traces of vampire presence in Nordic cinematography. The author examines examples from traditional literature and points to the fact that even Viktor Rydberg’s Vampyren – for many years, the only representative of Nordic vampiric literature – does not depict a ‘canonic’ vampire. Wajda tries to answer a question: is it possible to find a vampire figure among rare examples of Nordic horror films from the twentieth century? In 1932, Carl Theodor Dreyer depicted the figure of a vampire in an unorthodox way. The author of this article indicates that vampirism was not a source of superpower as in American cinema. The presented study advances an understanding of vampire presence in Nordic cinema and proposes an analysis of selected films that can be deciphered as examples of ‘a vampire unseen’on-screen. Furthermore, the author compares ‘vampire unseen’ creations with the modern approach to vampires.
Maximal arcs in projective planes of order 16 and related designs
Authors: Gezek Mustafa , Tonchev Vladimir D. , Wagner Tim 
Published: March 2018

AbstractThe resolutions and maximal sets of compatible resolutions of all 2-(120,8,1) designs arising from maximal (120,8)-arcs, and the 2-(52,4,1) designs arising from previously known maximal (52,4)-arcs, as well as some newly discovered maximal (52,4)-arcs in the known projective planes of order 16, are computed. It is shown that each 2-(120,8,1) design associated with a maximal (120,8)-arc is embeddable in a unique way in a projective plane of order 16. This result suggests a possible strengthening of the Bose–Shrikhande theorem about the embeddability of the complement of a hyperoval in a projective plane of even order. The computations of the maximal sets of compatible resolutions of the 2-(52,4,1) designs associated with maximal (52,4)-arcs show that five of the known projective planes of order 16 contain maximal arcs whose associated designs are embeddable in two nonisomorphic planes of order 16.
Existence of Three Positive Solutions for a Nonlocal Singular Dirichlet Boundary Problem
Authors: Giacomoni Jacques , Mukherjee Tuhina , Sreenadh Konijeti 
Published: March 2018

AbstractIn this article, we prove the existence of at least three positive solutions for the following nonlocal singular problem:{(-Δ)s⁢u=λ⁢f⁢(u)uq,u>0⁢ in ⁢Ω,u=0in ⁢ℝn∖Ω,\left\{\begin{aligned} \displaystyle(-\Delta)^{s}u&\displaystyle=\lambda\frac{% f(u)}{u^{q}},&&\displaystyle u>0\text{ in }\Omega,\\ \displaystyle u&\displaystyle=0&&\displaystyle\phantom{}\text{in }\mathbb{R}^{% n}\setminus\Omega,\end{aligned}\right.where(-Δ)s{(-\Delta)^{s}}denotes the fractional Laplace operator fors∈(0,1){s\in(0,1)},n>2⁢s{n>2s},q∈(0,1){q\in(0,1)},λ>0{\lambda>0}and Ω is a smooth bounded domain inℝn{\mathbb{R}^{n}}. Heref:[0,∞)→[0,∞){f:[0,\infty)\to[0,\infty)}is a continuous nondecreasing map satisfyinglimu→∞⁡f⁢(u)uq+1=0.\lim_{u\to\infty}\frac{f(u)}{u^{q+1}}=0.We show that under certain additional assumptions onf, the above problem possesses at least three distinct solutions for a certain range of λ. We use the method of sub-supersolutions and a critical point theorem by Amann [H. Amann, Fixed point equations and nonlinear eigenvalue problems in ordered Banach spaces, SIAM Rev. 18 1976, 4, 620–709] to prove our results. Moreover, we prove a new existence result for a suitable infinite semipositone nonlocal problem which played a crucial role to obtain our main result and is of independent interest.
Optimization of freeform surfaces using intelligent deformation techniques for LED applications
Authors: Isaac Annie Shalom , Neumann Cornelius 
Published: March 2018

Abstract
For many years, optical designers have great interests in designing efficient optimization algorithms to bring significant improvement to their initial design. However, the optimization is limited due to a large number of parameters present in the Non-uniform Rationaly b-Spline Surfaces. This limitation was overcome by an indirect technique known as optimization using freeform deformation (FFD). In this approach, the optical surface is placed inside a cubical grid. The vertices of this grid are modified, which deforms the underlying optical surface during the optimization. One of the challenges in this technique is the selection of appropriate vertices of the cubical grid. This is because these vertices share no relationship with the optical performance. When irrelevant vertices are selected, the computational complexity increases. Moreover, the surfaces created by them are not always feasible to manufacture, which is the same problem faced in any optimization technique while creating freeform surfaces. Therefore, this research addresses these two important issues and provides feasible design techniques to solve them. Finally, the proposed techniques are validated using two different illumination examples: street lighting lens and stop lamp for automobiles.
Gracilaria microcarpasp. nov. (Gracilariaceae, Rhodophyta) from the southwestern Gulf of Mexico
Authors: Dreckmann Kurt M. , Núñez Resendiz María Luisa , Sentíes Abel 
Published: March 2018

AbstractAlthough the genusGracilariais well represented on the Mexican coasts, there are few studies focused on the taxonomic aspects and the clarification of the relationships between species. The high morphological plasticity exhibited by several of its representatives could underestimate the true species richness. In the present study, a group of cylindrical specimens ofGracilariafrom the southeastern Gulf of Mexico, previously identified asG. cornea, was collected. Based on COI-5P andrbcL sequences, these samples formed an independent group closely related toG. ferox, a flat species. Morphologically, our specimens differed fromG. feroxand the other species ofGracilariaby the presence of very small cystocarps and a thick pericarp composed of many layers of cells. We proposeGracilaria microcarpasp. nov. as the name for this group of cylindrical specimens from the Yucatan Peninsula of Mexico.
“No one can escape God”. A filicidal beneficial tale from early Byzantium
Authors: Vasileiou Fotis 
Published: March 2018

Abstract
John Moschos includes the story of a female filicide in his Spiritual Meadow. After exploring the authorial self of Moschos, this article discusses the relation between this beneficial story and the biblical book of Jonah on the one hand, and Euripides’ Iphigenia at Aulis and Medea on the other. Finally, the story is examined in the wider framework of the seventh century, in an attempt to understand John Moschos’ viewpoint on his own time.
Trefftz Discontinuous Galerkin Method for Friedrichs Systems with Linear Relaxation: Application to the P
1 Model
Authors: Morel Guillaume , Buet Christophe , Despres Bruno 
Published: March 2018

Abstract
This work deals with the first Trefftz Discontinuous Galerkin (TDG) scheme for a model problem of transport with relaxation. The model problem is written as a

P
N

{P_{N}}

or

S
N

{S_{N}}

model, and we study in more details the

P
1

{P_{1}}

model in dimension 1 and 2. We show that the TDG method provides natural well-balanced and asymptotic preserving discretization since exact solutions are used locally in the basis functions. High-order convergence with respect to the mesh size in two dimensions is proved together with the asymptotic property for

P
1

{P_{1}}

model
in dimension one. Numerical results in dimensions 1 and 2 illustrate the theoretical properties.
Provenance analysis of the Late Triassic Yichuan Basin: constraints from zircon U-Pb geochronology
Authors: Meng Xianghong , Zhang Yu , Wang Duoyun , Zhang Xue 
Published: March 2018

AbstractLaser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) U-Pb dating has been performed on detrital zircons from the Chunshuyao Formation sandstone of Yichuan Basin. The ages of 85 detrital zircon grains are divided into three groups: 252-290 Ma, 1740-2000 Ma, and 2400-2600 Ma. The lack of Early Paleozoic and Neoproterozoic U-Pb ages indicates that there is no input from the Qinling Orogen, because the Qinling Orogen is characterized by Paleozoic and Neoproterozoic material. In combination with previous research, we suggest that the source of the Chunshuyao Formation is most likely recycled from previous sedimentary rocks from the North China Craton. In the Late Triassic, the Funiu ancient land was uplifted which prevented source material from the Qinling Orogen. Owing to the Indosinian orogeny, the strata to the east of the North China Craton were uplifted and eroded. The Yichuan Basin received detrital material from the North China Craton.
Spiritual Care und die multiprofessionelle Zusammenarbeit von Seelsorgern und Psychotherapeuten im ambulanten Kontext
Authors: Boettcher Birthe 
Published: March 2018

ZusammenfassungZur Einbindung von Spiritualität/Religiosität (S/R) in die klinische Behandlung gibt es mittlerweile verschiedene konzeptuelle Ansätze, die unter dem Begriff Spiritual Care gefasst werden können. Bisher finden diese Konzepte außerhalb des klinischen Kontextes nur wenig Berücksichtigung, obwohl Spiritualität und Religiosität sowohl als Ressource, aber auch als Stressor nicht übersehen werden sollten. Der Artikel stellt die derzeitige Situation der interdisziplinären Zusammenarbeit mit Blickrichtung auf den Einbezug von S/R im klinischen Setting dar, um im Anschluss daran am Beispiel von Psychotherapeuten und Seelsorgern zu überlegen, inwiefern die konzeptuellen Ansätze auch für das ambulante Setting genutzt werden könnten. Es wird dabei im Rahmen der Diskussion auch auf Möglichkeiten und Herausforderungen der Zusammenarbeit eingegangen.
Nominalization patterns in Alto Perené, a Kampa Arawak language of Peru
Authors: Mihas Elena 
Published: March 2018

Abstract
The paper investigates the inventory of nominalizing forms and examines restrictions on the morphosyntactic behavior of lexical and clausal nominalizations in Alto Perené (also called Ashéninka Perené), a Kampa Arawak language of Peru. It is shown that the deverbalization of lexical nominalizations is basically total. The substantivization cline of lexical nominalizations is characterized by various degrees of acquisition of nominal properties. Clausal nominalizations are found to retain aspect and realis marking and preserve argument structure. Clausal realis nominalizations display a variety of nominal characteristics such as spatial case, nominal plural number, and definiteness marking. Clausal irrealis nominalizations show highly restricted nominal properties. The relativization strategy is formed with the help of the participant nominalizers -ri and -ni.
The Artificial Hamiltonian, First Integrals, and Closed-Form Solutions of Dynamical Systems for Epidemics
Authors: Naz Rehana , Naeem Imran 
Published: March 2018

Abstract
The non-standard Hamiltonian system, also referred to as a partial Hamiltonian system in the literature, of the form

q
˙

i

=

∂
H

∂

p
i

,

p
˙

i

=
−

∂
H

∂

q
i

+

Γ
i

(
t
,

q
i

,

p
i

)

${\dot q^i} = \frac{{\partial H}}{{\partial {p_i}}},{\text{ }}{\dot p^i} = - \frac{{\partial H}}{{\partial {q_i}}} + {\Gamma ^i}(t,{\text{ }}{q^i},{\text{ }}{p_i})$

appears widely in economics, physics, mechanics, and other fields. The non-standard (partial) Hamiltonian systems arise from physical Hamiltonian structures as well as from artificial Hamiltonian structures. We introduce the term ‘artificial Hamiltonian’ for the Hamiltonian of a model having no physical structure. We provide here explicitly the notion of an artificial Hamiltonian for dynamical systems of ordinary differential equations (ODEs). Also, we show that every system of second-order ODEs can be expressed as a non-standard (partial) Hamiltonian system of first-order ODEs by introducing an artificial Hamiltonian. This notion of an artificial Hamiltonian gives a new way to solve dynamical systems of first-order ODEs and systems of second-order ODEs that can be expressed as a non-standard (partial) Hamiltonian system by using the known techniques applicable to the non-standard Hamiltonian systems. We employ the proposed notion to solve dynamical systems of first-order ODEs arising in epidemics.
Combined Blockade of Interleukin-1α and -1β Signaling Protects Mice from Cognitive Dysfunction after Traumatic Brain Injury
Authors: Newell Elizabeth A. , Todd Brittany P. , Mahoney Jolonda , Pieper Andrew A. , Ferguson Polly J. , Bassuk Alexander G. 
Published: March 2018

AbstractDiffuse activation of interleukin-1 inflammatory cytokine signaling after traumatic brain injury (TBI) elicits progressive neurodegeneration and neuropsychiatric dysfunction, and thus represents a potential opportunity for therapeutic intervention. Although interleukin (IL)-1α and IL-1β both activate the common type 1 IL-1 receptor (IL-1RI), they manifest distinct injury-specific roles in some models of neurodegeneration. Despite its potential relevance to treating patients with TBI, however, the individual contributions of IL-1α and IL-1β to TBI-pathology have not been previously investigated. To address this need, we applied genetic and pharmacologic approaches in mice to dissect the individual contributions of IL-1α, IL-β, and IL-1RI signaling to the pathophysiology of fluid percussion–mediated TBI, a model of mixed focal and diffuse TBI. IL-1RI ablation conferred a greater protective effect on brain cytokine expression and cognitive function after TBI than did individual IL-1α or IL-1β ablation. This protective effect was recapitulated by treatment with the drug anakinra, a recombinant naturally occurring IL-1RI antagonist. Our data thus suggest that broad targeting of IL-1RI signaling is more likely to reduce neuroinflammation and preserve cognitive function after TBI than are approaches that individually target IL-1α or IL-1β signaling.