bluuebunny/crossref_metadata_2025_split huggingface dataset:
Devitalization of adjacent teeth following maxillary sinus floor augmentation: A retrospective radiographic study
Authors: Beck Florian , Lauterbrunner Nina , Lettner Stefan , Stavropoulos Andreas , Ulm Christian , Bertl Kristina 
Published: October 2018

AbstractBackgroundElevation of the schneiderian membrane, during maxillary sinus floor augmentation (MSFA) may theoretically result in devitalization of adjacent teeth, which are in a close spatial relationship to the sinus floor.PurposeTo assess retrospectively the probability of devitalization of teeth adjacent to the osteotomy site after MSFA in a relatively large number of patients.Materials and MethodsAll MSFA procedures, performed at a university oral surgery clinic within a time period of 10 years, were assessed on the following eligibility criteria: (1) presence of vital teeth (ie, not root canal treated and no periapical radiolucency on a panoramic radiograph taken just after MSFA), (2) presence of a 3 to 12 months postoperative radiograph of the teeth adjacent to the osteotomy site displaying the root apices, and (3) complete medical records up to at least 12 months postoperatively. The radiographs of the different time points were compared and any changes in the radiographic status of the adjacent teeth (eg, development of a periapical lesion, root canal treatment, etc.) were recorded and the spatial relationship of the adjacent teeth to the maxillary sinus classified.ResultsOut of 684 MSFAs, 257 fulfilled the inclusion criteria and involved 357 adjacent teeth, of which 221 presented close to and/or intimate relationship to the sinus. In only a single case, tooth vitality might have been lost due to the procedure. Thus, the probability for tooth devitalization for teeth with close to and/or intimate spatial relationship to the sinus floor ranged from 0.45% to 0.7%.ConclusionsEven for teeth with apices very close to and/or intimately related to the sinus tooth devitalization after MSFA is an extremely rare complication; that is, the probability of tooth devitalization after MSFA is ≤0.7%.
Clinical outcomes of implants placed in ridge‐preserved versus nonpreserved sites: A 4‐year randomized clinical trial
Authors: Marconcini Simone , Giammarinaro Enrica , Derchi Giacomo , Alfonsi Fortunato , Covani Ugo , Barone Antonio 
Published: October 2018

AbstractBackgroundConsistent bone changes occur after tooth removal, often compromising the success of implants placed within the socket left to natural healing The long‐term effect of ridge preservation on implant outcomes is still unclear.PurposeThe aim of the study was to assess success and survival rates of implants placed in extraction sockets, with spontaneous healing, or grafted with cortical porcine bone, or collagenated corticocancellous porcine bone.Materials and methodsNinety patients in need for a single premolar/molar tooth extraction and an implant treatment were selected for the present study. Patients were randomly distributed among 3 groups: sites that healed naturally (ctrl), or sites that received ridge preservation with either cortical (cort) or collagenated corticocancellous porcine bone (coll). Three months after, all the experimental sites were reentered to insert implants. Marginal bone levels were recorded; soft tissues were analyzed and summarized with the Pink Esthetic Score (PES). Forty‐two patients out of 90 (initial cohort study) completed the entire follow‐up of 4 years.ResultsCumulative survival and success rates for all implants were 100% at a 4‐year evaluation. Mean marginal bone loss (MBL) was 1.14 ± 0.23 mm in the cort group, 1.13 ± 0.29 mm in the coll group, and 1.92 ± 0.07 mm in the ctrl group. There were no significant differences between the 2 grafting materials but MBL was significantly greater in the nongrafted sites (P value < .001). The PES resulted significantly better (9.42 ± 0.75) for the cort group than for the coll group (8.53 ± 1.18) and ctrl group (6.07 ± 1.89) at 4‐year evaluation.ConclusionsRidge preservation was more effective than natural healing in preserving marginal bone and in achieving better esthetic outcomes around implants 4 years after placement. The cortical porcine bone showed better clinical outcomes than collagenated corticocancellous porcine bone.
Biological and technical complications of tilted implants in comparison with straight implants supporting fixed dental prostheses. A systematic review and meta‐analysis
Authors: Apaza Alccayhuaman Karol Alí , Soto‐Peñaloza David , Nakajima Yasushi , Papageorgiou Spyridon N. , Botticelli Daniele , Lang Niklaus P. 
Published: October 2018

AbstractObjectivesTo evaluate the implant failure, marginal bone loss (MBL), and other biological or technical complications of restorations supported by tilted and straight implants after at least 3 years in function.MethodsElectronic and manual searches were performed in MEDLINE, Embase, Web of Science, and OpenGrey to identify clinical studies published up to December 2017. After duplicate study selection and data extraction, the risk of bias was assessed with the ROBINS‐I tool. Random‐effects meta‐analyses of relative risks (RRs) or mean differences (MD) and their 95% confidence intervals (CIs) were performed, followed by subgroup/sensitivity analyses and application of the GRADE approach.ResultsA total of 17 nonrandomized studies (eight prospective/nine retrospective) were included. The number of implants of the overall systematic review was 7,568 implants placed in 1,849 patients supporting either full‐arch or partial implant prostheses. No difference in the failure of tilted and straight implants was seen (eight studies; 4,436 implants; RR = 0.95; 95% CI = 0.70 to 1.28; p = 0.74), with the quality of evidence being very low due to bias and imprecision. Likewise, no difference in MBL was seen between tilted and straight implants (16 studies; 5,293 implants; MD = 0.03 mm; 95% CI = −0.03 to 0.10 mm; p = 0.32), with the quality of evidence being very low due to bias and inconsistency. Contradictory results regarding implant survival were found from prospective and retrospective studies, which could indicate bias from the latter.ConclusionsWithin the limitations of the present systematic review, no effect of implant inclination on implant survival or peri‐implant bone loss was found.
Reconstructive aspects: Summary and consensus statements of group 3. The 5th EAO Consensus Conference 2018
Authors: Sailer Irena , Mühlemann Sven , Kohal Ralf J. , Spies Benedikt C. , Pjetursson Bjarni E. , Lang Niklaus P. , Gotfredsen Klaus L. , Ellingsen Jan E. , Francisco Helena , Özcan Mutlu , Hassan Bassam , Esteve‐Pardo Guillem , Bardaji Javier A. , Kraus Riccardo D. , Wennerberg Ann 
Published: October 2018

AbstractObjectivesThe tasks of this working group were to evaluate the existing evidence on the efficiency and efficacy of the digital and conventional workflows for the fabrication of fixed implant reconstructions, to assess the performance of all‐ceramic fixed implant reconstructions and, finally, to evaluate the outcomes of internally and externally connected implant abutments and reconstructions.MethodsFour reviews were available analyzing the current literature on the respective topics. One review dealt with the efficiency and efficacy of digital and conventional fabrication workflows. Two reviews analyzed the outcomes of all‐ceramic fixed implant reconstructions, one focusing on single‐implant reconstructions and the other evaluating multiple‐unit implant fixed dental prostheses (FDPs). The fourth review evaluated the clinical outcome on external, respectively, internal implant‐abutment connections. These reviews were the basis for the discussions within the group and at the plenary sessions.ResultsThe present consensus report gives the consensus statements, the clinical recommendations, and the implications for future research as discussed and approved by the plenum of the consensus conference. The four manuscripts by Mühlemann et al., Rabel et al., Pieralli et al., and Pjetursson et al. are published as part of the journal supplement of the present EAO consensus conference.
A systematic review of the influence of the implant‐abutment connection on the clinical outcomes of ceramic and metal implant abutments supporting fixed implant reconstructions
Authors: Pjetursson Bjarni Elvar , Zarauz Cristina , Strasding Malin , Sailer Irena , Zwahlen Marcel , Zembic Anja 
Published: October 2018

AbstractObjectivesThe objective of this systematic review was to assess the influence of implant‐abutment connection and abutment material on the outcome of implant‐supported single crowns (SCs) and fixed dental prostheses (FDPs).MethodsAn electronic Medline search complemented by manual searching was conducted to identify randomized controlled clinical trials, prospective and retrospective studies with a mean follow‐up time of at least 3 years. Patients had to have been examined clinically at the follow‐up visit. Failure and complication rates were analyzed using robust Poisson regression, and comparisons were made with multivariable Poisson regression models.ResultsThe search provided 1511 titles and 177 abstracts. Full‐text analysis was performed for 147 articles resulting in 60 studies meeting the inclusion criteria. Meta‐analysis of these studies indicated an estimated 5‐year survival rate of 97.6% for SCs and 97.0% for FDPs supported by implants with internal implant‐abutment connection and 95.7% for SCs and 95.8% for FDPs supported by implants with external connection. The 5‐year abutment failure rate ranged from 0.7% to 2.8% for different connections with no differences between the types of connections. The total number of complications was similar between the two connections, yet, at external connections, abutment or occlusal screw loosening was more predominant. Ceramic abutments, both internally and externally connected, demonstrated a significantly higher incidence of abutment fractures compared with metal abutments.ConclusionFor implant‐supported SCs, both metal and ceramic abutments with internal and external connections exhibited high survival rates. Moreover, implant‐supported FDPs with metal abutments with internal and external connections for also showed high survival rates.
Impact of social deprivation, demographics and centre on HbA1c outcomes with continuous subcutaneous insulin infusion
Authors: Paisley A. N. , Beynon J. , Fullwood C. , Hindle A. , Alam T. , Urwin A. , Chapman A. , Morris J. , Thabit H. , Rutter M. K. , Leelarathna L. 
Published: October 2018

AbstractAimsTo assess the impact of social deprivation, demographics and centre on HbA1c outcomes with continuous subcutaneous insulin infusion (CSII) in adults with Type 1 diabetes.MethodsDemographic data, postcode‐derived English Index of Multiple Deprivation data and 12‐month average HbA1c (mmol/mol) pre‐ and post‐CSII were collated from three diabetes centres in the north west of England, University Hospital of South Manchester (UHSM), Salford Royal Foundation Hospital (SRFT) and Manchester Royal Infirmary (MRI). Univariable and multivariable regression models explored relationships between demographics, Index of Multiple Deprivation, centre and HbA1c outcomes.ResultsData were available for 693 (78%) individuals (UHSM, n = 90; SRFT, n = 112; and MRI, n = 491) of whom 59% were women. Median age at CSII start was 39 (IQR 29.5–49.0) years and median diabetes duration was 20 (11–29) years. Median Index of Multiple Deprivation was 15 193 (6313–25 727). Overall median HbA1c improved from 69 to 64 mmol/mol (8.5% to 8.0%) within the first year of CSII. In multivariable analysis, higher pre‐CSII HbA1c was significantly associated with higher deprivation (P = 0.036), being female (P < 0.001), and centre (MRI; P = 0.005). Following pre‐CSII HbA1c adjustment, post‐CSII HbA1c or HbA1c change were not related to demographic factors and deprivation, but remained significantly related to the centre; UHSM and SRFT had larger reductions in HbA1c with CSII compared with MRI [median −7.0 (−0.6%) vs. −6.0 (−0.55%) vs. −4.5 (−0.45%) mmol/mol; P = 0.005].ConclusionsHigher pre‐CSII HbA1c levels were associated with higher deprivation and being female. CSII improves HbA1c irrespective of social deprivation and demographics. Significant differences in HbA1c improvements were observed between centres. Further work is warranted to explain these differences and minimize variation in clinical outcomes with CSII.
Impact of maternal income on the risk of gestational diabetes mellitus in primiparous women
Authors: Rönö K. , Masalin S. , Kautiainen H. , Gissler M. , Raina M. , Eriksson J. G. , Laine M. K. 
Published: October 2018

AbstractAimsFindings concerning the impact of socio‐economic status on the risk of gestational diabetes mellitus (GDM) are inconclusive and little is known about the simultaneous impact of income and educational attainment on the risk of GDM. This study aims to assess the impact of maternal prepregnancy income in combination with traditional GDM risk factors on the incidence of GDM in primiparous women.MethodsThis is an observational cohort study including 5962 Finnish women aged ≥ 20 years from the city of Vantaa, Finland, who delivered for the first time between 2009 and 2015, excluding women with pre‐existing diabetes mellitus. The Finnish Medical Birth Register, Finnish Tax Administration, Statistics Finland, Social Insurance Institution of Finland and patient healthcare records provided data for the study. We divided the study population according to five maternal income levels and four educational attainment levels.ResultsIncidence of GDM decreased with increasing income level in primiparous women (P < 0.001 for linearity, adjusted for smoking, age, BMI and cohabiting status). In an adjusted two‐way model, the relationship was significant for both income (P = 0.007) and education (P = 0.039), but there was no interaction between income and education (P = 0.52).ConclusionsThere was an inverse relationship between both maternal prepregnancy taxable income and educational attainment, and the risk of GDM in primiparous Finnish women.
Treatment with incretins does not increase the risk of pancreatic diseases compared to older anti‐hyperglycaemic drugs, when added to metformin: real world evidence in people with Type 2 diabetes
Authors: Montvida O. , Green J. B. , Atherton J. , Paul S. K. 
Published: October 2018

AbstractAimsIn people with metformin‐treated diabetes, to evaluate the risk of acute pancreatitis, pancreatic cancer and other diseases of the pancreas post second‐line anti‐hyperglycaemic agent initiation.MethodsPeople with Type 2 diabetes diagnosed after 2004 who received metformin plus a dipeptidyl peptidase‐4 inhibitor (DPP‐4i, n = 50 095), glucagon‐like peptide‐1 receptor agonist (GLP‐1RA, n = 12 654), sulfonylurea (n = 110 747), thiazolidinedione (n = 17 597) or insulin (n = 34 805) for at least 3 months were identified in the US Centricity Electronic Medical Records. Time to developing acute pancreatitis, other diseases of the pancreas and pancreatic cancer was estimated, balancing and adjusting anti‐hyperglycaemic drug groups for appropriate confounders.ResultsIn the DPP‐4i group, the adjusted mean time to acute pancreatitis was 2.63 [95% confidence intervals (CI) 2.38, 2.88] years; time to pancreatic cancer was 2.70 (2.19, 3.21) years; and time to other diseases of the pancreas was 2.73 (2.33, 3.12) years. Compared with DPP‐4i, the insulin group developed acute pancreatitis 0.48 years (P < 0.01) earlier and the GLP‐1RA group developed pancreatic cancer 3 years later (P < 0.01). However, with the constraint of no event within 6 months of insulin initiation, the risk of acute pancreatitis in the insulin group was insignificant. No other significant differences were observed between groups.ConclusionsNo significant differences in the risk of developing pancreatic diseases in those treated with various anti‐hyperglycaemic drug classes were found.
Small‐scale observation on the effects of burrowing activities of ants on soil hydraulic processes
Authors: Li T. C. , Shao M. A. , Jia Y. H. , Jia X. X. , Huang L. M. , Gan M. 
Published: October 2018

SummaryAnts alter soil structure when making their nests and the fresh soil aggregates brought to the surface become available for erosion. However, the effects of burrowing activities of ants on soil hydrological processes are unclear. In this study, the effects of Tetramorium caespitum, Messor aciculatus and Camponotus japonicus nests on the preferential flow and soil surface hydrologic processes at a small scale were assessed on the Loess Plateau. Soil dyeing and rainfall simulation experiments were conducted to quantify the effects of ants' nests on runoff and water infiltration on slopes. The diameters of nest entrances for T. caespitum, M. aciculatus and C. japonicus were 0.19, 0.33 and 0.56 cm, respectively. The nests of M. aciculatus and C. japonicus promoted water infiltration, resulted in large soil water contents and decreased surface runoff. The turret‐like mounds around the nest entrances made by T. caespitum prevented the formation of soil preferential flow. The depths of dyeing in the soil with M. aciculatus and C. japonicus nests were 32.6 and 49.2 cm, respectively, which were significantly (P < 0.05) deeper than those in the soil with T. caespitum nests (10.0 cm) and no nest (10.3 cm). The unstable soil aggregates made by ants on the soil surface break down easily and encourage the loss of soil sediment. The results show that increasing the ant colonies, especially those with larger bodies, could be considered a strategy to increase water infiltration and soil water content in semiarid areas. In the meantime, the sediment loss cannot be neglected.Highlights

This study evaluated the effects of hypogeal ants on soil erosion.
The turret‐like mounds of T. caespitum prevent the formation of preferential flow.
Ants with larger bodies made bigger nest entrances and resulted in more infiltration.
The burrowing activities of ants exacerbate soil erosion.
Disease progression in blepharospasm: a 5‐year longitudinal study
Authors: Ferrazzano G. , Conte A. , Gigante A. , Defazio G. , Berardelli A. , Fabbrini G. 
Published: October 2018

Background and purposeThe clinical manifestation of dystonic spasms in blepharospasm (BSP) patients may be heterogeneous. Whether the varying phenomenology of eyelid spasms becomes manifest sequentially during the course of the disease or aggregates in separate clusters according to different disease courses is still unclear. For this purpose, the clinical features in BSP patients were evaluated longitudinally over a 5‐year period and also the blink reflex recovery cycle was tested in a subgroup of BSP patients.MethodsSixty BSP patients were videotaped at time 0 and after approximately 5 years of follow‐up. Two experts in movement disorders, who were blinded to the video order, reviewed the videotapes and scored the severity of BSP using the Blepharospasm Severity Rating Scale. Changes in the R2 recovery index were also evaluated in 18 patients twice, i.e. upon enrolment and at the follow‐up.ResultsThe severity of BSP worsened significantly over the 5‐year follow‐up period owing to the appearance or the increased duration and frequency of prolonged spasms. It was also found that the blink reflex recovery cycle worsened at follow‐up in comparison with the baseline.ConclusionsThis study shows that the disease progression of BSP is characterized by the appearance or worsening of prolonged spasms. Prolonged spasms are accompanied by changes in the excitability of brainstem interneurons. Aging‐related effects may exacerbate the pathophysiological mechanisms underlying spasms.
Inflammation is a potential risk factor of voriconazole overdose in hematological patients
Authors: Gautier‐Veyret Elodie , Truffot Aurélie , Bailly Sébastien , Fonrose Xavier , Thiebaut‐Bertrand Anne , Tonini Julia , Cahn Jean‐Yves , Stanke‐Labesque Françoise 
Published: October 2018

AbstractVoriconazole (VRC) overdoses are frequent and expose patients at high risk of adverse effects. This case–control study performed in hematological patients who benefited from VRC therapeutic drug monitoring from January 2012 to December 2015 aimed to identify risk factors of VRC overdose. Pharmacogenetic, biological, and demographic parameters at the time of VRC trough concentration (Cmin) were retrospectively collected from medical records. Cases (VRC overdose: defined by a VRC Cmin ≥ 4 mg/L; n = 31) were compared to controls (no VRC overdose: defined by VRC Cmin < 4 mg/L; n = 31) using nonparametric or chi‐square tests followed by multivariable analysis. VRC overdoses were significantly associated with high CRP and bilirubin levels, intravenous administration, and age in univariable analysis. In contrast, the proportion of CYP genotypes (CYP2C19, CYP3A4, or CYP3A5, considered alone or combined in a combined genetic score) were not significantly different between patients who experienced a VRC overdose and those who did not. In multivariable analysis, the class of CRP level (defined by median CRP levels of 96 mg/L) was the sole independent risk factor of VRC overdose (P < 0.01). Patients with CRP levels > 96 mg/L) had a 27‐fold (IC 95%: [6–106]) higher risk of VRC overdose than patients with CRP levels ≤ 96 mg/L. This study demonstrates that inflammatory status, assessed by CRP levels, is the main risk factor of VRC overdose in French hematological patients, whereas pharmacogenetic determinants do not appear to be involved.
Thyroiditis and immune check point inhibitors: the post‐marketing experience using the French National Pharmacovigilance database
Authors: Garon‐Czmil Julie , Petitpain Nadine , Rouby Franck , Sassier Marion , Babai Samy , Yelehe‐Okouma Melissa , Weryha Georges , Klein Marc , Gillet Pierre 
Published: October 2018

AbstractImmunotherapy with immune checkpoint inhibitors (ICIs) for cancer has become increasingly prescribed in recent years. Indeed, it is used to treat both solid and hematological malignancies due to their considerable potential in treating melanoma, non‐small cell lung and other cancers. Immune‐mediated related adverse endocrine toxicity, and especially thyroiditis, is seen as a growing problem needing specific screening and management. This study aims at describing thyroid dysfunctions induced by the ICIs marketed in France, which are registered in the French Pharmacovigilance database. This database was queried for nivolumab, pembrolizumab, and ipilimumab‐induced adverse drug reactions reported before April 30, 2017. Both a pharmacologist and an endocrinologist have reviewed each case to select only those of peripheral thyroiditis (thyrotoxicosis and hypothyroidism). During this period, 110 thyroiditis following ICI therapy were reported. Sex/ratio was around one. Most of the cases (47.2%) were asymptomatic. Although some thyrotoxicosis cases were severe, no orbitopathy was reported. Hypothyroidism and thyrotoxicosis were equally described. Antithyroid antibodies were positive in only 16% patients. The ultrasonography was informative in 19% patients. Levothyroxine supplementation was necessary in 57% patients, leading to 19% recovery. With a dedicated optimized management, most of the cases did not require immunotherapy discontinuation. Finally, immune‐mediated related thyroiditis is increasing due to a wider prescription of ICI therapy in various cancer conditions and systematic screening. Often asymptomatic, they lead to a local activation accompanied by hormonal deficiency in the long run. It is necessary to carry out an early and sustained multidisciplinary screening to allow immunotherapy continuation.