bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Template‐Directed Metal–Organic Frameworks Network and the Derived Honeycomb‐Like Carbon Flakes via Confinement Pyrolysis
Authors: Wang Jie , Tang Jing , Ding Bing , Chang Zhi , Hao Xiaodong , Takei Toshiaki , Kobayashi Naoya , Bando Yoshio , Zhang Xiaogang , Yamauchi Yusuke 
Published: February 2018

AbstractMetal–organic frameworks (MOFs) have become a research hotspot since they have been explored as convenient precursors for preparing various multifunctional nanomaterials. However, the preparation of MOF networks with controllable flake morphology in large scale is not realized yet. Herein, a self‐template strategy is developed to prepare MOF networks. In this work, layered double‐metal hydroxide (LDH) and other layered metal hydroxides are used not only as a scaffold but also as a self‐sacrificed metal source. After capturing the abundant metal cations identically from the LDH by the organic linkers, MOF networks are in situ formed. It is interesting that the MOF network‐derived carbon materials retain the flake morphology and exhibit a unique honeycomb‐like macroporous structure due to the confined shrinkage of the polyhedral facets. The overall properties of the carbon networks are adjustable according to the tailored metal compositions in LDH and the derived MOFs, which are desirable for target‐oriented applications as exemplified by the electrochemical application in supercapacitors.
An Indispensable Role of Androgen Receptor in Wnt Responsive Cells During Prostate Development, Maturation, and Regeneration
Authors: He Yongfeng , Hooker Erika , Yu Eun-Jeong , Wu Huiqing , Cunha Gerald R. , Sun Zijie 
Published: February 2018

Abstract
Androgen signaling is essential for prostate development, morphogenesis, and regeneration. Emerging evidence indicates that Wnt/β-catenin signaling also contributes to prostate development specifically through regulation of cell fate determination. Prostatic Axin2-expressing cells are able to respond to Wnt signals and possess the progenitor properties to regenerate prostatic epithelium. Despite critical roles of both signaling pathways, the biological significance of androgen receptor (AR) in Axin2-expressing/Wnt-responsive cells remains largely unexplored. In this study, we investigated this important question using a series of newly generated mouse models. Deletion of Ar in embryonic Axin2-expressing cells impaired early prostate development in both ex vivo and tissue implantation experiments. When Ar expression was deleted in prostatic Axin2-expressing cells at pre-puberty stages, it results in smaller and underdeveloped prostates. A subpopulation of Axin2 expressing cells in prostate epithelium is resistant to castration and, following androgen supplementation, is capable to expand to prostatic luminal cells. Deletion of Ar in these Axin2-expressing cells reduces their regenerative ability. These lines of evidence demonstrate an indispensable role for the Ar in Wnt-responsive cells during the course of prostate development, morphogenesis, and regeneration, which also imply an underlying interaction between the androgen and Wnt signaling pathways in the mouse prostate.
Delphinidin induces apoptosis and inhibits epithelial‐to‐mesenchymal transition via the ERK/p38 MAPK‐signaling pathway in human osteosarcoma cell lines
Authors: Kang Hae‐Mi , Park Bong‐Soo , Kang Hyun‐Kyung , Park Hae‐Ryoun , Yu Su‐Bin , Kim In‐Ryoung 
Published: February 2018

AbstractDelphinidin is major anthocyanidin that is extracted from many pigmented fruits and vegetables. This substance has anti‐oxidant, anti‐inflammatory, anti‐angiogenic, and anti‐cancer properties. In addition, delphinidin strongly suppresses the migration and invasion of various cancer cells during tumorigenesis. Although delphinidin has anti‐cancer effects, little is known about its functional roles in osteosarcoma (OS). For these reasons, we have demonstrated the effects of delphinidin on OS cell lines. The effects of delphinidin on cell viability and growth of OS cells were assessed using the MTT assay and colony formation assays. Hoechst staining indicated that the delphinidin‐treated OS cells were undergoing apoptosis. Flow cytometry, confocal microscopy, and a western blot analysis also indicated evidence of apoptosis. Inhibition of cell migration and invasion was found to be associated with epithelial‐to‐mesenchymal transition (EMT), observed by using a wound healing assay, an invasion assay, and a western blot analysis. Furthermore, delphinidin treatment resulted in a profound reduction of phosphorylated forms of ERK and p38. These findings demonstrate that delphinidin treatment suppressed EMT through the mitogen‐activated protein kinase (MAPK) signaling pathway in OS cell lines. Taken together, our results suggest that delphinidin strongly inhibits cell proliferation and induces apoptosis. Delphinidin treatment also suppresses cell migration and prevents EMT via the MAPK‐signaling pathway in OS cell lines. For these reasons, delphinidin has anti‐cancer effects and can suppress metastasis in OS cell lines, and it might be worth using as an OS therapeutic agent.
Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels
Authors: Jin Cuiyuan , Luo Ting , Fu Zhengwei , Jin Yuanxiang 
Published: February 2018

AbstractImazalil (IMZ), which is a widely used fungicide, can accumulate in the body and threaten an animal's health. However, this fungicide has adverse effects on aquatic organisms and ultimately affects human health when it leaches into the environment. Our research tried to determine that if IMZ might cause liver damage and its potential to cause‐related diseases. In this study, male adult C57BL/6 mice were exposed to 0.1, 0.5, or 2.5 mg/kg body weight IMZ in drinking water for 15 weeks. Then, we evaluated the liver damage at the physiological, biochemical, and transcriptome levels in mice after chronic IMZ exposure. We observed serious ballooning degeneration of hepatocytes in the IMZ‐treated groups. And IMZ induced oxidative stress and caused the disorders of bile acid metabolism in mice. In addition, the transcriptome data showed that IMZ has substantial influence on several pathways, including metabolic pathways for drug metabolism, RNA transport, and bile secretion. We further confirmed that the mRNA expression of the key genes involved in oxidative stress and bile acid metabolism were changed of mice exposed to IMZ. Our data suggested that chronic IMZ exposure could induce hepatotoxicity in mice at the physiological, biochemical, and transcriptome levels.
Patient perceptions of acute pain and activity disruption following inguinal hernia repair: a propensity-matched comparison of robotic-assisted, laparoscopic, and open approaches
Authors: Bittner IV James G. , Cesnik Lawrence W. , Kirwan Thomas , Wolf Laurie , Guo Dongjing 
Published: February 2018

Abstract
Few publications describe the potential benefit of robotic-assisted inguinal hernia repair on acute postoperative groin pain (APGP). This study compared patients’ perceptions of APGP, activity limitation, and overall satisfaction after robotic-assisted- (R), laparoscopic (L), or open (O) inguinal hernia repair (IHR). Random samples of patients from two web-based research panels and surgical practices were screened for patients who underwent IHR between October 28, 2015 and November 1, 2016. Qualified patients were surveyed to assess perceived APGP at 1 week postoperatively, activity disruption, and overall satisfaction. Three cohorts based on operative approach were compared after propensity matching. Propensity scoring resulted in 83 R-IHR matched to 83 L-IHR respondents, while 85 R-IHR matched with 85 O-IHR respondents. R-IHR respondents recalled less APGP compared to respondents who had O-IHR (4.1 ± 0.3 vs 5.6 ± 0.3, p < 0.01) but similar APGP compared to L-IHR (4.0 ± 0.3 vs 4.4 ± 0.3, p = 0.37). Respondents recalled less activity disruption 1 week postoperatively after R-IHR versus O-IHR (6.1 ± 0.3 vs. 7.3 ± 0.2, p < 0.01) but similar levels of activity disruption after R-IHR and L-IHR (6.0 ± 0.3 vs. 6.6 ± 0.27, p = 0.32). At the time of the survey, respondents perceived less physical activity disruption after R-IHR compared to O-IHR (1.4 ± 0.2 vs. 2.8 ± 0.4, p < 0.01) but similar between R-IHR and L-IHR (1.3 ± 0.2 vs 1.2 ± 0.2, p = 0.94). Most respondents felt satisfied with their outcome regardless of operative approach. Patient perceptions of pain and activity disruption differ by approach, suggesting a potential advantage of a minimally invasive technique over open for IHR. Further studies are warranted to determine long-term outcomes regarding pain and quality of life after IHR.
Smart multifunctional nanoagents for in situ monitoring of small molecules with a switchable affinity towards biomedical targets
Authors: Shevchenko Konstantin G. , Cherkasov Vladimir R. , Nikitina Irina L. , Babenyshev Andrey V. , Nikitin Maxim P. 
Published: February 2018

Abstract
The great diversity of nanomaterials provides ample opportunities for constructing effective agents for biomedical applications ranging from biosensing to drug delivery. Multifunctional nanoagents that combine several features in a single particle are of special interest due to capabilities that substantially exceed those of molecular drugs. An ideal theranostic agent should simultaneously be an advanced biosensor to identify a disease and report the diagnosis and a biomedical actuator to treat the disease. While many approaches were developed to load a nanoparticle with various drugs for actuation of the diseased cells (e.g., to kill them), the nanoparticle-based approaches for the localized biosensing with real-time reporting of the marker concentration severely lag behind. Here, we show a smart in situ nanoparticle-based biosensor/actuator system that dynamically and reversibly changes its structural and optical properties in response to a small molecule marker to allow real-time monitoring of the marker concentration and adjustment of the system ability to bind its biomedical target. Using the synergistic combination of signal readout based on the localized surface plasmon resonance and an original method of fabrication of smart ON/OFF-switchable nanoagents, we demonstrate reversible responsiveness of the system to a model small molecule marker (antibiotic chloramphenicol) in a wide concentration range. The proposed approach can be used for the development of advanced multifunctional nanoagents for theranostic applications.
200 ka of glacial events in NW Svalbard: an emergence cycle facies model and regional correlations
Authors: Alexanderson Helena , Henriksen Mona , Ryen Heidi T. , Landvik Jon Y. , Peterson Gustaf 
Published: February 2018

Abstract
Late Quaternary sedimentary units at Kongsfjordhallet, NW Svalbard, represent five cycles of glaciations and subsequent deglaciations during high relative sea levels. The high sea level events are interpreted as glacioisostatically induced and imply preceding regional glaciations, which we constrain in time by luminescence and radiocarbon ages to just prior to ~ 195, ~ 130, ~ 85, ~ 60, and ~ 15 ka. Combined with the stratigraphical record from nearby Leinstranda we identify six, possibly seven, major glacial advances during the last 200 ka in the Kongsfjorden region. Two of these occurred during the Saalian and at least four during the Weichselian. The results are based on detailed sedimentological, stratigraphical and chronological investigations of the uppermost 15 m of the 40-m-high Kongsfjordhallet coastal sections. The succession is dominated by sediments of marine and littoral origin, representing partial shallowing-upward sequences due to isostatic rebound. Only one subglacial till was recognised. Interestingly, alluvial and periglacial deposits, not commonly recognised in this type of setting, occur in the sequence. These include weathered coarse alluvium, sandy channel fills as well as cryoturbated sediments and solifluction deposits, which are positive evidence of a non-glacial environment. The sequence of sediments that represents an emergence cycle has been formalised in a facies model.
Análise biomecânica da reconstrução do ligamento cruzado anterior
Authors: Completo António , Noronha José Carlos , Oliveira Carlos , Fonseca Fernando 
Published: February 2018

Resumo
Objetivo A reconstrução do ligamento cruzado anterior é aconselhável sobretudo em atletas de alta demanda física. Diversas técnicas são usadas na reconstrução, mas a grande questão é qual o melhor posicionamento para o enxerto. Analisar o efeito biomecânico da posição dos túneis ósseos na repartição de carga e cinemática da articulação, bem como os resultados funcionais em médio prazo, após reconstrução do ligamento cruzado anterior.
Métodos Fez-se um estudo de simulação biomecânica computacional com modelos de elementos finitos do joelho original e com reconstrução do ligamento cruzado anterior (Neo-LCA) em quatro combinações de posição dos túneis ósseos (femoral central-tibial central, femoral anterior-tibial central, femoral posterossuperior-tibial anterior e femoral central-tibial anterior) com o mesmo tipo de enxerto. Para cada modelo, foram comparadas a pressão de contato na cartilagem, a rotação e translação do fêmur e dos meniscos e a deformação nos ligamentos.
Resultados Nenhum modelo de Neo-LCA foi capaz de reproduzir, na íntegra, o modelo do joelho original. Quando o túnel femoral era colocado em posição mais posterior, observaram-se pressões na cartilagem 25% mais baixas e translação dos meniscos superiores entre 12% e 30% relativamente ao modelo intacto. Quando o túnel femoral estava em posição mais anterior, observou-se uma rotação interna do fêmur 50% inferior ao modelo intacto.
Conclusão Os resultados evidenciam que uma localização do túnel femoral mais distante da posição central parece ser mais preponderante para um comportamento mais díspar relativamente à articulação intacta. Na posição mais anterior existe um aumento da instabilidade rotatória.
Un curieux emploi de la négation en français canadien
Authors: Follette James E. La ,   en collaboration avec, Valin Roch 
Published: February 2018

Le Français commun dit régulièrement, comme chacun sait, C’est le plus beau blé qu’il yAITsur le marché, construisant au subjonctif le verbe de la proposition subordonnée. Un trait du parler populaire de la région de Québec — observé aussi ailleurs au Canada français — consiste à substituer ici au subjonctif, lorsque le verbe est un verbe d’existence, un indicatif accompagné de la négation (réduite à pas) et à dire: C’est le plus beau blé qu’il y A PAS sur le marché.Cet emploi en apparence aberrant de la négation est-il une innovation du français canadien ou représente-t-il, au contraire, l’usage ancien d’un des divers parlers régionaux français apportés en Nouvelle-France aux XVIIe et XVIIIe siècles? Ce n’est pas notre intention d’éclairer ce point d’histoire. Notre propos est tout différent. Prenant acte des deux usages observés et de leur divergeance, nous démontrerons—en nous appuyant, pour ce faire, sur l’analyse psychomécanique du langage du linguiste français Gustave Guillaume — que, en face de la nuance de pensée à exprimer, les deux manières de dire s’équipollent, la négation d’une forme verbale indicative produisant en l’occurrence le même effet de sens que l’emploi affirmatif d’une forme de subjonctif.
A structure-function description of Terena phrases
Authors: Bendor-Samuel John T. 
Published: February 2018

The object of this article is to illustrate a particular model of grammatical description by using it to describe the Terena phrase. This model can, for convenience, be given the label “structure-function.” Like any model it employs certain interrelated categories and terms which are mutually defining. Each category can only be understood in reference to the model as a whole.This model sets up grammatical units which are hierarchically arranged. The hierarchy consists of a series of levels of description. At each level there is a grammatical unit and this grammatical unit gives its name to the level concerned. At a given level there is only one grammatical unit. Each such grammatical unit consists of one or more of the units next below it in the hierarchy.
Eléments …: A. Martinet or G. Rondeau?
Authors: Wittman Henri 
Published: February 2018

In 1961 G. Rondeau published in this journal an article entitled “Les unités linguistiques de base chez A. Martinet,” in which his intention was to discuss, “aussi objectivement que possible,” the basic linguistic units as they appear in A. Martinet’s handbook for beginners in linguistics.Objectivity? A. Martinet states in his preface that certain novel elements are to be found in chapter IV, the chapter dealing with morphology and syntax. And since G. Rondeau’s article discusses Martinet’s principles of morphology rather than the “unités linguistiques” in general, one would have expected that Rondeau would have aimed his arguments mainly against these forty-nine pages of chapter IV. But it appears that the reviewer has been unwilling to extend his interest into this chapter.
Valeurs sémantiques du verbe en français et en anglais
Authors: Darbelnet J. 
Published: February 2018

La Stylistique Comparée commence seulement à prendre conscience de son champ d’action et de ses méthodes. Aussi les spécialistes des disciplines voisines n’aperçoivent-ils pas toujours clairement quels sont ses buts et ses moyens. Pour se justifier à ce stade de son développement, il est important qu’elle choisisse des secteurs nettement délimités où elle puisse mettre sa méthode au point et obtenir des résultats auxquels la grammaire et la linguistique descriptive n’arrivent pas aussi facilement.C’est dans cet esprit que la présente étude se propose de comparer le verbe anglais et le verbe français dans leurs façons de satisfaire certains besoins d’expression, et, plus particulièrement, d’examiner dans les deux langues le comportement du verbe par rapport à deux dichotomies, celle qui oppose le langage propre au langage figuré et celle du mouvement et du déplacement. Pour ce faire, elle sera obligée de se placer tantôt sur le plan des signifiés et tantôt sur celui des signifiants. Dans les deux cas, certains termes seront employés dans un sens qu’il importe de préciser.
South China Sea Arbitration and its Application to Dokdo
Authors: LEE Seokwoo , BERNARD Leonardo 
Published: February 2018

AbstractOn 12 July 2016, the Arbitral Tribunal formed under Annex VII of the 1982 United Nations Convention on the Law of the Sea issued its decision on the proceeding brought by the Philippines against China relating to certain activities in the South China Sea. The Tribunal’s decision was hotly anticipated as it dealt with various important issues relating to law of the sea and the interpretation of the Convention. It dealt with issues including the jurisdiction of the Tribunal, the legal status of maritime features, historic rights, and duty to preserve the marine environment. Although it remains to be seen whether states will follow the Tribunal’s precedent, questions arose on whether such precedent can be applied to other unresolved issues in other parts of the world. This paper looks at the application of the precedent established by the South China Sea arbitration to the situation involving Dokdo between Korea and Japan.
Enforcement Options and Paths to Compliance: Disputants and Global Stakeholders inPhilippines v. China
Authors: DESIERTO Diane A. 
Published: February 2018

AbstractThePhilippines v. Chinaarbitration award has been praised as a landmark victory setting forth illuminating jurisprudence interpreting the UN Convention on the Law of the Sea [UNCLOS], but it has also been repeatedly excoriated as an “unenforceable” decision—a Pyrrhic victory—due to China’s repeated refusal to date to acknowledge the binding effect of the award. China’s withdrawal from Scarborough Shoal—hailed by the new Duterte government as a hallmark of its diplomatic efforts—is one instance of state practice that still remains equivocal on theopinio jurisof China’s acceptance (or rejection) of the arbitration award.
Homework Expectancy Value Scale for Undergraduates in Online	Environments
Authors: Xu Jianzhong , Fan Xitao , Du Jianxia , Cai Zhihui 
Published: February 2018

Abstract. The goal of the current study was to validate the Homework Expectancy Value Scale (HEVS) for undergraduates in online learning environments. After randomly splitting the sample in halves, we conducted exploratory factor analysis (EFA) with the first half ( n = 306) and confirmatory factor analysis (CFA) with the second half ( n = 306). Both EFA and CFA results indicated that HEVS consisted of two factors: Expectancy and Value. Given an adequate level of measurement invariance, we further examined the latent mean difference across gender for the entire sample ( n = 612). Our findings showed no statistically significant mean differences in Expectancy and Value across gender. Finally, consistent with theoretical expectations, Expectancy and Value were negatively correlated with homework distraction and the frequency of attending online classes without homework, and positively correlated with homework emotion regulation and homework completion.
Psychometric Properties of the Spanish Version of the Child	Problematic Traits Inventory in 3- to 12-Year-Old Spanish	Children
Authors: López-Romero Laura , Molinuevo Beatriz , Bonillo Albert , Andershed Henrik , Colins Olivier F. , Torrubia Rafael , Romero Estrella 
Published: February 2018

Abstract. The aim of this study was to test the reliability and validity of the Spanish teacher-rated Child Problematic Traits Inventory (CPTI) in two community samples of 3- to 12-year-old children. Confirmatory Factor Analysis (CFA) supported the three-factor structure of the CPTI (Grandiose-Deceitful: GD; Callous-Unemotional: CU; Impulsive-Need for Stimulation: INS), being invariant across gender and age groups. The CPTI total and factor scores showed excellent internal consistencies (> .90) in the total group, and across gender and age groups. In support of their criterion validity, the CPTI scores were positively related to psychopathy scores as measured by an alternative teacher-rated measure. In support of their convergent validity, the CPTI scores showed the expected relations to variables that have been linked to psychopathic personality, including fearlessness, conduct problems, aggression, and low prosocial behavior. Overall, these findings suggest that the Spanish teacher-rated version of the CPTI has good psychometric properties and seems to be a promising tool for studying psychopathic traits in children.
Expanding frontiers in materials chemistry and physics with multiple anions
Authors: Kageyama Hiroshi , Hayashi Katsuro , Maeda Kazuhiko , Attfield J. Paul , Hiroi Zenji , Rondinelli James M. , Poeppelmeier Kenneth R. 
Published: February 2018

AbstractDuring the last century, inorganic oxide compounds laid foundations for materials synthesis, characterization, and technology translation by adding new functions into devices previously dominated by main-group element semiconductor compounds. Today, compounds with multiple anions beyond the single-oxide ion, such as oxyhalides and oxyhydrides, offer a new materials platform from which superior functionality may arise. Here we review the recent progress, status, and future prospects and challenges facing the development and deployment of mixed-anion compounds, focusing mainly on oxide-derived materials. We devote attention to the crucial roles that multiple anions play during synthesis, characterization, and in the physical properties of these materials. We discuss the opportunities enabled by recent advances in synthetic approaches for design of both local and overall structure, state-of-the-art characterization techniques to distinguish unique structural and chemical states, and chemical/physical properties emerging from the synergy of multiple anions for catalysis, energy conversion, and electronic materials.