bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated Functional High‐Strength Hydrogels with Metal‐Coordination Complexes and H‐Bonding Dual Physically Cross‐linked Networks
Authors: Li Xuefeng , Li Rongzhe , Liu Zuifang , Gao Xiang , Long Shijun , Zhang Gaowen 
Published: August 2018

AbstractWith the deepening of research on high‐strength hydrogels, the multi‐functional study of hydrogels has become a hot spot. In this paper, a dual cross‐linked physical high‐strength hydrogels is prepared by a relatively simple method. 2‐Vinyl‐ 4,6‐Diamino‐2‐vinyl‐1,3,5‐triazine (VDT) induces the formation of the first cross‐linking points through the interaction of hydrogen bonds with poly(acrylamide‐co‐acrylic acid) (PAm‐co‐Ac) chains, then the secondary physical cross‐linkers Fe3+ that introduce ionic coordinates between Fe3+ and –COO− groups. Due to the synergistic effect of hydrogen bonding and ionic coordination, hydrogels possess high tensile strength (approx. 4.34 MPa), large elongation (approx. 17.64 times), and good healing properties under alkali solution after cutting into two pieces. Meanwhile, VDT contains diaminotriazine functional groups that easily form hydrogen bonds so that the polymer of hydrogels could absorb 5‐fluorouridine. In addition, the contribution of ionic polymer segments enables pH to be sensitive to hydrogels and facilitates the adsorption of a large number of ionic monomers to form ionic conductive networks, the prepared hydrogel capacitor device has very high sensitivity to pressure and deformation, and can detect the movement behavior of the human body. The dual‐physical cross‐linked hydrogels had a selective adsorption to biological small molecules and could be assembled into a flexible wearable device with high sensitivity.
Soluble Hyperbranched Porous Organic Polymers
Authors: Yang Yuwan , Feng Lingyun , Ren Jun , Liu Yunfei , Jin Shangbin , Su Li , Wood Colin , Tan Bien 
Published: August 2018

AbstractSoluble porous organic polymers (SPOPs) are currently the subject of extensive investigation due to the enhanced processability compared to insoluble counterparts. Here, a new concept for the construction of SPOPs is presented, which combines the unique topological structure of hyperbranched polymers with rigid building blocks. By using this facile, one‐step strategy, a class of novel SPOPs which possess surface areas up to 646 m2 g−1 have been synthesized. The extended π‐conjugated backbone affords the polymers bright fluorescence under UV irradiation. Interestingly, after dissolution in a suitable solvent that was slowly evaporated, the polymers retain a large extent of porosity. The SPOPs are potential candidates for gas storage and separation, photovoltaic, and biological applications. In particular, due to the presence of an internal porous structure and open conformations, they show high drug loading efficiency (1.91 g of ibuprofen per gram), which is considerably higher than conventional porous organic polymers.
Targeting EGFRL858R/T790M and EGFRL858R/T790M/C797S resistance mutations in NSCLC: Current developments in medicinal chemistry
Authors: Lu Xiaoyun , Yu Lei , Zhang Zhang , Ren Xiaomei , Smaill Jeff B. , Ding Ke 
Published: August 2018

AbstractBoth the first‐generation reversible epidermal growth factor receptor (EGFR) inhibitors gefitinib and erlotinib and the second‐generation covalent epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) afatinib have significantly improved the survival of non‐small‐cell lung cancer (NSCLC) patients with activating EGFR mutations. However, a secondary EGFRT790M mutation leads to the clinically acquired resistance to the first‐ and second‐generation EGFR‐TKIs drugs. A number of the third‐generation wild‐type sparing EGFR inhibitors, for example, WZ4002, CO1686, AZD9291, HM61713, EGF816, ASP8173, and PF0674775, have been developed, among which AZD9291 has been approved by US FDA for the treatment of NSCLC patients with EGFRT790M. More recently, a tertiary EGFRC797S mutation was reported as the dominant resistance mechanism to the third‐generation irreversible inhibitors. It is highly desirable to develop the fourth‐generation EGFR inhibitors. This review summarizes the mechanisms of acquired resistance and the latest medicinal chemistry advances on the third‐ and fourth‐generation EGFR inhibitors, with special attention being paid to the allosteric and reversible inhibitors combating the tertiary EGFRC797S mutation.
Diverse Excretion Pathways of Benzyl Glucosinolate in Humans after Consumption of Nasturtium (Tropaeolum majus L.)—A Pilot Study
Authors: Kühn Carla , Kupke Franziska , Baldermann Susanne , Klopsch Rebecca , Lamy Evelyn , Hornemann Silke , Pfeiffer Andreas F. H. , Schreiner Monika , Hanschen Franziska S. , Rohn Sascha 
Published: August 2018

ScopeDifferent metabolic and excretion pathways of the benzyl glucosinolate breakdown products benzyl isothiocyanate and benzyl cyanide are investigated to obtain information about their multiple fate after ingestion. Detailed focus is on the so far underestimated transformation/excretion pathways—protein conjugation and exhalation.Methods and resultsMetabolites, protein conjugates, and non‐conjugated isothiocyanates are determined in plasma, urine, and breath of seven volunteers after consuming freeze‐dried nasturtium or bread enriched with nasturtium. Samples are collected up to 48 h at selected time points. The metabolites of the mercapturic acid pathway are detectable in plasma up to 24 h after consumption. Additionally, mercapturic acid is the main metabolite in urine, but non‐conjugated benzyl isothiocyanate is detectable as well. Protein conjugates show high amounts in plasma even 48 h after consumption. In breath, benzyl isothiocyanate and benzyl cyanide are detectable up to 48 h after consumption.ConclusionIsothiocyanates are not only metabolized via the mercapturic acid pathway, but also form protein conjugates in blood and are exhaled. To balance intake and excretion, it is necessary to investigate all potential metabolites and excretion routes. This has important implications for the understanding of physiological and pharmacological effects of isothiocyanate‐containing products.
Cromolyn/gelatin mixtures as aqueous alignment media and utilization of their mechanical stability for a layering technique
Authors: Niklas Thomas , Schulze Philipp , Farès Christophe 
Published: August 2018

AbstractIn this study, aqueous blends of cromolyn and gelatin (“cromogels”) are introduced as anisotropic media. The addition of gelatin enables an advantageous adjustability of the strength, the homogeneity, and the stability of the cromolyn alignment. The mechanical stability of these polymer‐dispersed liquid crystals is further utilized by stacking layers of D2O/cromolyn/gelatin with varying component ratio. The resulting distinct phases with correspondingly different degrees of alignment can be targeted by spatially resolved NMR techniques. As a case study, we investigated sucrose in a two‐phase system with neat D2O and analyte layered over the anisotropic medium. A recently presented spatially selective coupled‐type HSQC experiment allows the determination of one‐bond C‐H splitting in both phases.
Assessing recrudescence of photoregressed Siberian hamster ovaries using in vitro whole ovary culture
Authors: Shahed Asha , Young Kelly A. 
Published: August 2018

AbstractIn vitro culture has been used to study different aspects of ovarian function; however, this technique has not been applied to study recrudescence, or the return of ovarian function in seasonally breeding species. In Siberian hamsters, exposure to inhibitory photoperiods induces declines in ovarian function, which are restored with photostimulation. Because these changes are mediated by changes in systemic gonadotropin (GT) secretion, we hypothesized that culturing photoregressed ovaries with GT would restore aspects of function and induce expression of key folliculogenic factors. Adult female Siberian hamsters were exposed to either long‐day (LD; 16L:8D) or short‐day (SD; 8L:16D) photoperiods for 14 weeks to maintain in vivo cyclicity or induce gonadal regression, respectively. Isolated ovaries were then cultured for 10 days with or without GT. Ovarian mass and messenger RNA (mRNA) expression of mitotic marker Pcna were increased in cultured SD ovaries (cSD) ovaries with GT as compared to without GT, with no changes noted among cultured LD (cLD) ovaries. Media estradiol and progesterone concentrations increased in both cLD and cSD ovaries cultured with GT as compared to without GT. No differences in follicle numbers or incidence of apoptosis were noted across groups. In addition, differential mRNA expression of folliculogenic growth factors (
Bmp‐4,
Ntf‐3,
Inh‐α,
Gdf‐9, Igf‐1, Has‐2, and Cox‐2) was observed in cSD treated with or without GT. Together, these results suggest that this in vitro model could be a useful tool to (a) study the return of function in photoregressed ovaries, and (b) to identify the specific roles folliculogenic factors play in ovarian recrudescence.
Mathematical Disease Progression Modeling in Type 2/3 Spinal Muscular Atrophy
Authors: Jacqmin Philippe , Gieschke Ronald , Delor Isabelle , Snoeck Eric , Vianna Eduardo , Vuillerot Carole , Sanwald Ducray Patricia 
Published: August 2018

ABSTRACTIntroduction: We propose a mathematical model to empirically describe spinal muscular atrophy (SMA) progression assessed by the 3 domains of the motor function measure (MFM) scale. The model implements development and deterioration of muscle function. Methods: Nonlinear mixed‐effects modeling was applied to data from 2 observational studies and 1 prospective clinical efficacy study comprising 190 healthy participants and 277 patients with type 2/3 SMA. Results: The model evidenced correlations between parameter estimates for different MFM domains. Slower development in MFM domain D1 (standing and transfers) was associated with faster deterioration for MFM domains D2 (proximal and axial motricity) and D3 (distal motor function). Discussion: The model describes all individual data well, although sparseness and variability of observational data prevented numerically stable estimation of parameters. Treatment duration in clinical studies was too limited to determine a proper drug‐effect model that could differentiate between symptomatic and disease modifying effects. Muscle Nerve 58: 528–535, 2018
Targeting PDGF‐mediated recruitment of pericytes blocks vascular mimicry and tumor growth
Authors: Thijssen Victor LJL , Paulis Yvette WJ , Nowak‐Sliwinska Patrycja , Deumelandt Katrin L , Hosaka Kayoko , Soetekouw Patricia MMB , Cimpean Anca M , Raica Marius , Pauwels Patrick , van den Oord Joost J , Tjan‐Heijnen Vivianne CG , Hendrix Mary J , Heldin Carl‐Henrik , Cao Yihai , Griffioen Arjan W 
Published: August 2018

AbstractAggressive tumor cells can adopt an endothelial cell‐like phenotype and contribute to the formation of a tumor vasculature, independent of tumor angiogenesis. This adoptive mechanism is referred to as vascular mimicry and it is associated with poor survival in cancer patients. To what extent tumor cells capable of vascular mimicry phenocopy the angiogenic cascade is still poorly explored. Here, we identify pericytes as important players in vascular mimicry. We found that pericytes are recruited by vascular mimicry‐positive tumor cells in order to facilitate sprouting and to provide structural support of the vascular‐like networks. The pericyte recruitment is mediated through platelet‐derived growth factor (PDGF)‐B. Consequently, preventing PDGF‐B signaling by blocking the PDGF receptors with either the small tyrosine kinase inhibitor imatinib or blocking antibodies inhibits vascular mimicry and tumor growth. Collectively, the current study identifies an important role for pericytes in the formation of vascular‐like structures by tumor cells. Moreover, the mechanism that controls the pericyte recruitment provides therapeutic opportunities for patients with aggressive vascular mimicry‐positive cancer types. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Production and characterization of ureaurethane elastomers with rapeseed‐based polyol
Authors: Mizera Kamila , Ryszkowska Joanna , Kurańska Maria , Prociak Aleksander 
Published: August 2018

AbstractThe purpose of this study was to evaluate the effect of rapeseed‐oil‐based (RO) polyol on the thermal and mechanical properties of tested ureaurethane elastomers (EPUUs). The chemical structure and degree of phase separation connected to the value of hydrogen bonds were tested by infrared spectroscopy. Thermal degradation was examined by TGA. The glass transition temperature and the enthalpy of heat effects were analysed by DSC. The mechanical properties were tested by dynamic mechanical thermal analysis and static tensile strength. The physicomechanical properties were also examined, including wear resistance and hardness of the tested materials. The use of RO polyol in 10–40 wt% concentration in polyol premixes changed the chemical structure of the EPUUs indicating a change in the quantity of hydrogen bonds and the degree of phase separation. DSC analysis showed that addition of the RO polyol causes an increase in the glass transition temperature of the soft phase in the EPUUs. © 2018 Society of Chemical Industry
Structure and dynamics of polypyrrole/chitosan nanocomposites
Authors: Ali Asmaa A , Elmahdy Mahdy M , Sarhan Afaf , Abdel Hamid Maysa I , Ahmed Moustafa T 
Published: August 2018

AbstractPolypyrrole/chitosan (PPy/Cs) nanocomposites with various amounts of polypyrrole nanoparticles (PPy‐NPs) have been synthesized and afterwards exposed to UV irradiation for 240 min. Structure, dynamics and antibacterial activity of pure compounds and the corresponding nanocomposites were investigated by means of wide‐angle X‐ray scattering, Fourier transform infrared spectroscopy, transmission electron microscopy, thermogravimetric analysis, broadband dielectric spectroscopy and antibacterial activity assay. The occurrence of a pronounced interaction between PPy‐NPs and Cs has been verified. Broadband dielectric spectroscopy measurements revealed two relaxation processes at low and high frequencies. The low‐frequencyα‐relaxation associated with the glass–rubber transition is attributed to the presence of hydrogen‐bonded water (plasticizing effect) appearing at low temperature (<373 K). The high‐frequencyσ‐relaxation is related to water molecules which become desorbed upon heating atT > 373 K and demonstrates Arrhenius temperature dependence with activation energy in the range 70–90 kJ mol−1in good agreement with previous reports. On the contrary, PPy‐NPs do not show any structural relaxation process and the charge transport mechanism follows the correlated barrier hopping model. All PPy/Cs nanocomposites exhibit an improved antibacterial activity against bothStaphylococcus aureusandEscherichia colibacteria as compared with pure Cs and PPy‐NPs. © 2018 Society of Chemical Industry
Efficient organic photovoltaic cells based on thiazolothiazole and benzodithiophene copolymers with π‐conjugated bridges
Authors: Park Junhoo , Park Jong Baek , Ha Jong‐Woon , Park Hea Jung , Kang In‐Nam , Hwang Do‐Hoon 
Published: August 2018

ABSTRACTNew donor–π–acceptor (D–π–A) type conjugated copolymers, poly[(4,8‐bis((2‐hexyldecyl)oxy)benzo[1,2‐b:4,5‐b′]dithiophene)‐alt‐(2,5‐bis(4‐octylthiophen‐2‐yl)thiazolo[5,4‐d]thiazole)] (PBDT‐tTz), and poly[(4,8‐bis((2‐hexyldecyl)oxy)benzo[1,2‐b:4,5‐b′]dithiophene)‐alt‐(2,5‐bis(6‐octylthieno[3,2‐b]thiophen‐2‐yl)thiazolo[5,4‐d]thiazole)] (PBDT‐ttTz) were synthesized and characterized with the aim of investigating their potential applicability to organic photovoltaic active materials. While copolymer PBDT‐tTz showed a zigzagged non‐linear structure by thiophene π‐bridges, PBDT‐ttTz had a linear molecular structure with thieno[3,2‐b]thiophene π‐bridges. The optical, electrochemical, morphological, and photovoltaic properties of PBDT‐tTz and PBDT‐ttTz were systematically investigated. Furthermore, bulk heterojunction photovoltaic devices were fabricated by using the synthesized polymers as p‐type donors and [6,6]‐phenyl‐C71‐butyric acid methyl ester as an n‐type acceptor. PBDT‐ttTz showed a high power conversion efficiency (PCE) of 5.21% as a result of the extended conjugation arising from the thienothiophene π‐bridges and enhanced molecular ordering in the film state, while PBDT‐tTz showed a relatively lower PCE of 2.92% under AM 1.5 G illumination (100 mW/cm2). © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1978–1988
Poly‐p‐phenylenevinylene‐g‐poly(2‐(methacryloyloxy)Ethyl)trimethylammonium chloride (PPV‐g‐PMETAC): A fluorescent, water‐soluble, selective anion sensor
Authors: Damavandi Mona , Pilkington Lisa I. , Malmström Jenny , Whitehead Kathryn A. , Travas‐Sejdic Jadranka , Barker David 
Published: August 2018

ABSTRACTThe photophysical and ion‐sensing properties of densely grafted conjugated polymer poly‐p‐phenylenevinylene‐g‐poly(2‐(methacryloyloxy)ethyl)trimethylammonium chloride (PPV‐g‐PMETAC) are presented herein. The grafted polymer exhibits excellent iodide‐sensing which is easily observed using fluorescence spectroscopy. The iodide detection limit for PPV‐g‐PMETAC was found to be 10 nM and was independent of temperature and pH <12. The change in fluorescence of PPV‐g‐PMETAC, upon exposure to iodide, was attributed to polymer aggregation due to changes in the morphology of the grafted PMETAC side chains, which was observed using atomic force microscopic and dynamic light scattering studies. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1997–2003
Synthesis of reactive three‐arm star‐shaped oligoimides with narrow molecular weight distribution
Authors: Kuznetsov Alexander A. , Soldatova Anastasiya E. , Tokmashev Roman Yu. , Tsegelskaya Anna Yu. , Semenova Galina K. , Shakhnes Alexander Kh. , Abramov Igor G. 
Published: August 2018

ABSTRACTSeries of star‐shaped three arms oligoimides (SOI) with terminal amino groups with narrow MWD ((Mw/Mn = 1.1–2) was synthesized by the one‐stage high‐temperature polycondensation in molten benzoic acid at 140 °C. The (B3+AB′) approach with the “slow addition of monomer” method was used for this synthesis, where B3 is 2,4,6‐tris(4‐aminophenoxy)toluene and AB′ is 3‐aminophenoxy phthalic acid. The SOI arm's length was controlled by the AB′/B3 mole ratio of 10:1, 20:1, 40:1, and 100:1. By the reaction of SOI's terminal amino groups with acetic anhydride, corresponding acetamide derivatives were obtained. SOI synthesized are soluble in selected organic solvents. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 2004–2009
Different dimensions of religiousness/spirituality are associated with health behaviors in breast cancer survivors
Authors: Park Crystal L. , Waddington Emily , Abraham Rachel 
Published: August 2018

AbstractObjectiveReligiousness/spirituality (R/S) may influence cancer survivors' health through multiple pathways. We aimed to examine one potentially key pathway that has seldom been examined: relationships between survivors' R/S and their health behaviors.MethodsThe present study investigated links between four core dimensions of R/S (beliefs, behaviors, identity, and coping) and three health behaviors (fruit/vegetable consumption, physical activity, and maintenance of a healthy weight) in 172 breast cancer survivors.ResultsBoth spiritual identity and use of religious coping were positively related to fruit and vegetable intake, while private prayer was marginally positively related. Both service attendance and religious identity (marginally) were related to engaging in less physical activity, while private prayer was positively related. Afterlife beliefs and private prayer were positively associated with BMI.ConclusionsR/S has complex but meaningful associations with health behaviors in breast cancer survivors. More research is needed to understand these relationships and to determine whether different dimensions of R/S may play useful roles in lifestyle change interventions.
Participation in a prostate cancer support group and health literacy
Authors: Haack Marius , Kofahl Christopher , Kramer Silke , Seidel Gabriele , von dem Knesebeck Olaf , Dierks Marie‐Luise 
Published: August 2018

AbstractBackgroundTo cope with prostate cancer (PC) and its consequences and to be certain about therapeutic alternatives, some patients seek mutual help in prostate cancer support groups (PCSGs), where they share information and find social support. Our study was intended to assess whether group participation is associated with health literacy (HL).MethodsWe compared PCSG members (n = 441) with PC patients without support group experiences (n = 135) in a cross‐sectional design. For this purpose, HL was operationalized through PC‐specific knowledge, noncancer‐specific knowledge about health care, guideline awareness, and skills needed to apply health information to meet own needs. Binary logistic regression models were calculated. Socio‐demographic data and disease‐related characteristics were used as control variables.ResultsKnowledge about PC (OR, 2.2; CI, 1.3‐3.7), the fact of having heard of guidelines (OR, 3.7; CI, 2.1‐6.8) and having read one (OR, 5.1; CI, 2.8‐9.4), and competencies regarding health service navigation (OR, 1.8; CI, 1.0‐3.1) are associated with PCSG membership. No statistically significant associations could be found between PCSG membership and further skills questioned, as well as between membership and knowledge about noncancer‐specific health care.ConclusionPCSG membership is associated with HL in some areas only. In particular, the groups seem to provide an important platform for information exchange in the field of PC. The potentially conflicting results on PC knowledge and the application skills may arise from the different forms of measurement—knowledge was tested; skills were self‐assessed.
An Efficient Synthesis of New Azide‐Nitrato‐Hydroxyl‐Terminated Polybutadiene by NaN3 and (NH4)2Ce(NO3)6
Authors: Ghayeni Hamid Reza , Razeghi Reza , Olyaei Abolfazl , Roosta Saeed Tavangar 
Published: August 2018

AbstractThis article reports way to functionalize hydroxyl‐terminated polybutadiene (HTPB) backbone by sodium azide and ceric ammonium nitrate, resulting in the formation of novel azide‐nitrato‐HTPB. In order to optimization of the effective parameters on the synthesis of azide‐nitrato‐HTPB, the starting material concentration, reaction time and temperature were investigated and the effect of these parameters on the azido‐nitrato functionalization of double bonds on HTPB backbone was evaluated. The functionalized HTPB by azidation (7.15 %) and nitration (5.17 %) showed viscosity of 17.6 Pa s−1, number average molecular weight of 2980 g mol−1 and hydroxyl value of 34 mg KOH per g.
Li4C4H2N2: A molecule with large hyperpolarizabilities and electride characteristic
Authors: Oliveira Igor M. , Castro Marcos A. , Leão Salviano A. , Fonseca Tertius L. , Pontes Renato B. 
Published: August 2018

AbstractWe design and systematically investigate the structural stability, electrical, and optical properties of a novel molecule named Li4C4H2N2 with electride characteristic. This molecule is obtained from pyridazine by replacing the two hydrogens opposed to the nitrogens by two lithium atoms and introducing other two lithium atoms bonded to the nitrogens. Dipole moment, polarizability, first and second hyperpolarizabilities, binding energies, excitation energies, and oscillator strengths of the Li4C4H2N2 molecule were computed at the coupled cluster with single and double excitations level through response theory. The binding energies of the lithium atoms to the nitrogens are larger than 70 kcal/mol, evidencing the high stability of the molecule investigated. The most representative results for β and γ are a.u. and a.u., respectively, indicating that this molecule has potential for application in nonlinear optical devices.