bluuebunny/crossref_metadata_2025_split huggingface dataset:
Airflow obstruction among ever‐employed U.S. adults aged 18‐79 years by industry and occupation: NHANES 2007‐2008 to 2011‐2012
Authors: Kurth Laura , Doney Brent , Halldin Cara , Hale Janet , Frenk Steven M. 
Published: December 2018

IntroductionThis study estimated the prevalence of spirometry‐defined airflow obstruction by industry and occupation and chronic obstructive pulmonary disease (COPD) among ever‐employed U.S. adults.MethodsData came from the National Health and Nutrition Examination Survey (NHANES) 2007‐2008 to 2011‐2012, a nationally representative study of the non‐institutionalized civilian U.S. population. Data on respondent's current and/or longest held job were used to create prevalence estimates and adjusted prevalence odds ratios (PORs) for airflow obstruction and COPD.ResultsAmong ever‐employed U.S. adults, airflow obstruction prevalence was 12.40% and COPD was 3.47%. High airflow obstruction prevalence and significant PORs were reported in mining; manufacturing; construction; and services to buildings industries as well as extraction; bookbinders, prepress, and printing; installers and repairers; and construction occupations.ConclusionPrevalence of airflow obstruction varies by industry and occupation. Industries and occupations with increased risk were identified using the most current NHANES data including detailed occupations and spirometry.
Synthesis of novel derivatives of 7,8‐dihydro‐6H‐imidazo[2,1‐b][1,3]benzothiazol‐5‐one and their virus‐inhibiting activity against influenza A virus
Authors: Galochkina Anastasia V. , Bollikanda Rakesh K. , Zarubaev Vladimir V. , Tentler Dmitry G. , Lavrenteva Irina N. , Slita Alexander V. , Chirra Nagaraju , Kantevari Srinivas 
Published: December 2018

AbstractInfluenza remains a highly pathogenic and hardly controlled human infection. The ability of selecting drug‐resistant variants necessitates the search and development of novel anti‐influenza drugs. Herein, we describe the synthesis and evaluation of a series of novel 2‐substituted 7,8‐dihydro‐6H‐imidazo[2,1‐b][1,3]benzothiazol‐5‐ones 3a–k for their virus‐inhibiting activity against influenza A virus. The new analogues 3a–k prepared in two steps from commercially available cyclohexane‐1,3‐diones were fully characterized by their NMR and mass spectral data. Among the new derivatives screened for cytotoxicity and in vitro antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1) in MDCK cells, three analogues 3i–k containing a thiophene unit were found to exhibit high virus‐inhibiting activity (high SI values) and a favorable toxicity profile. The compound 3j (CC50: >1000 μM, SI = 77) with higher potency is the best anti‐influenza hit analogue for further structural optimization and drug development. The most active compounds did not inhibit viral neuraminidase and possess therefore other targets and mechanisms of activity than the currently used neuraminidase inhibitors.
Control of VTOL aircraft with position state constraints using the Barrier Lyapunov Function
Authors: Zhao Dongfang , Liu Jinkun 
Published: December 2018

AbstractA Barrier Lyapunov Function (BLF) controller algorithm is proposed for position tracking control of vertical take‐off and landing (VTOL) aircraft with position state constraints. When VTOL performs missisons in a narrow space, the VTOL position states have to be restricted within the constrained region. To deal with the above problem, BLFs are employed to prevent position states from violating the constraints. The dynamic surface control method is applied to reduce the “explosion of terms” problem of the back‐stepping method. The stability analysis and simulation results illustrate the effectiveness of the proposed controller.
Docosahexaenoic acid promotes cell cycle arrest and decreases proliferation through WNT/β‐catenin modulation in colorectal cancer cells exposed to γ‐radiation
Authors: Murad Leonardo Borges , da Silva Nogueira Perôny , de Araújo Wallace Martins , Sousa‐Squiavinato Annie Cristhine Moraes , Rocha Murilo Ramos , de Souza Waldemir Fernandes , de‐Freitas‐Junior Júlio , Barcellos‐de‐Souza Pedro , Bastos Lilian Gonçalves , Morgado‐Díaz Jose Andrés 
Published: December 2018

AbstractThe effects of radiation are known to be potentiated by N‐3 polyunsaturated fatty acids, which modulate several signaling pathways, but the molecular mechanisms through which these fatty acids enhance the anticancer effects of irradiation in colorectal cancer (CRC) treatment remain poorly elucidated. Here, we aimed to ascertain whether the fatty acid docosahexaenoic acid (DHA) exerts a modulating effect on the response elicited by radiation treatment (RT). Two CRC cell lines, Caco‐2 and HT‐29, were exposed to RT, DHA, or both (DHA + RT) for various times, and then cell viability, proliferation, and clonogenicity were assessed. Moreover, cell cycle, apoptosis, and necrosis were analyzed using flow cytometry, and the involvement of WNT/β‐catenin signaling was investigated by immunofluorescence to determine nuclear β‐catenin, GSK3β phosphorylation status, and TCF/LEF‐activity reporter. DHA and RT applied separately diminished the viability of both HT‐29 and Caco‐2 cells, and DHA + RT caused a further reduction in proliferation mainly in HT‐29 cells, particularly in terms of colony formation. Concomitantly, our results verified cell cycle arrest in G0/G1 phase, a reduction of cyclin D1 expression, and a decrease in GSK3β phosphorylation after the combined treatment. Furthermore, immunofluorescence quantification revealed that nuclear β‐catenin was increased in RT‐exposed cells, but this effect was abrogated in cells exposed to DHA + RT, and the results of TCF/LEF‐activity assays confirmed that DHA attenuated the increase in nuclear β‐catenin activity induced by irradiation. Our finding shows that DHA applied in combination with RT enhanced the antitumor effects of irradiation on CRC cells, and that the underlying mechanism involved the WNT/β‐catenin pathway. © 2018 BioFactors, 45(1):24–34, 2019
Individual optimal attentional strategy during implicit motor learning boosts frontoparietal neural processing efficiency: A functional near‐infrared spectroscopy study
Authors: Sakurada Takeshi , Hirai Masahiro , Watanabe Eiju 
Published: December 2018

AbstractIntroductionOptimal focus of attention is a crucial factor for improving motor learning. Most previous studies have shown that directing attention to movement outcome (external focus; EF) is more effective than directing attention to body movement itself (internal focus; IF). However, our recent studies demonstrated that the optimal attentional strategy in healthy and clinical populations varies depending on individual motor imagery ability. To explore the neurological basis underlying individual optimal attentional strategy during motor learning tasks, in the present study, we measured frontoparietal activities using functional near‐infrared spectroscopy (fNIRS).MethodsTwenty‐eight participants performed a visuomotor learning task requiring circular tracking. During the task, the participants were required to direct their attention internally or externally. The individual optimal attentional strategy was determined by comparing the after‐effect sizes between the IF and EF conditions.ResultsFifteen participants showed larger after‐effects under the EF condition (External‐dominant), whereas the others showed larger after‐effects under the IF condition (Internal‐dominant). Based on the differences in neural activities between Internal‐ and External‐dominant groups, we identified the right dorsolateral prefrontal cortex (Brodmann area 46) and right somatosensory association cortex (Brodmann area 7) as the neural bases associated with individual optimal attentional strategy during motor learning. Furthermore, we observed a significant negative correlation, that is, lower activity in these areas was associated with a larger after‐effect size under the optimal attentional strategy.ConclusionOur findings demonstrated that more efficient neural processing in the frontoparietal area under the individual optimal attentional strategy can accelerate motor learning.
Separator Membranes for High Energy‐Density Batteries
Authors: Jana Karun Kumar , Lue Shingjiang Jessie , Huang Allen , Soesanto Jansen Fajar , Tung Kuo‐Lun 
Published: December 2018

AbstractRechargeable lithium‐ion, lithium‐sulfur, zinc‐air, and redox‐flow batteries are the most anticipated multipurpose platforms for future generations of electric vehicles, consumer devices, and portable electronics because of their high‐energy density and cost‐effective electrochemical energy storage. Over the past decades, a variety of novel separator membranes and electrolytes have been developed to improve rechargeable battery performance while not thoroughly addressing the issue of flammability, safety, and low cycling stability of high‐energy‐density batteries. This comprehensive review mainly underlines the optimization and modification of porous membranes for battery separator applications, covering four significant types: microporous separators, nonwoven mat separators, polymer electrolyte membranes, and composite membrane separators. Furthermore, the present trends in material selection for batteries are reviewed, and different choices of cathode, anode, separator, and electrolyte materials are discussed, which will also serve as key components to boost the development of next‐generation rechargeable batteries.
The Vital Balance of Graphitization and Defect Engineering for Efficient Bifunctional Oxygen Electrocatalyst Based on N‐doping Carbon/CNT Frameworks
Authors: Li Yinle , Liu Qinglin , Zhang Siqing , Li Guangqin 
Published: December 2018

AbstractDefects modulation generally has significant influence on the electronic structures and surface chemistry of porous carbon for the electrocatalysts. Here, nitrogen‐doped hierarchical porous carbon/N‐CNTs frameworks (Co@NC‐m) with the vital graphitization and defect engineering, which encapsulated with cobalt nanoparticles and fabricated by a simple carbonization of Co/Zn zeolitic benzimidazole framework. The as‐prepared optimal Co@NC‐0.75 shows outstanding catalytic performance for both ORR and OER, the potential gap between the ORR potential with a current density of −3 mA cm−2 and the OER potential with a current density of 10 mA cm−2 is 0.78 V, illustrating that it is one of the best MOFs‐derived bifunctional oxygen electrocatalysts reported to date. More importantly, the Co@NC‐0.75 demonstrates comparable catalytic performance and durability to those of commercial Pt/C for ORR and commercial RuO2 for OER. The superior bifunctional oxygen catalytic activity is mainly attributed to the vital balance between the degree of graphitization and defect engineering, which is proposed to enhance the electron transfer efficiency and conductivity. This work provides more opportunities for understanding and designing other porous graphitized carbon‐based electrocatalysts.
Aggregation‐induced Substrate Specificity in Aerobic Reduction of Olefins with Ultrasound Gel Catalyst of Synthetic Flavin
Authors: Kawamorita Soichiro , Fujiki Misa , Li Zimeng , Kitagawa Takahiro , Imada Yasushi , Naota Takeshi 
Published: December 2018

AbstractA riboflavin derivative bearing octadecanoyl functionalities 1 a gelatinizes a variety of organic solvents upon brief ultrasonication in an organic fluid. The rate of gelation with 1 a can be externally and precisely controlled by tuning the sonication time and type of solvent. The present ultrasound gel exhibits unprecedented substrate specificity for the catalytic aerobic reduction of olefins, which can be performed with hydrazine at ambient temperature and atmospheric pressure in air. The reaction rates of 1‐dodecene (2), allylbenzene (3), and o‐allylphenol (4) with the ultrasound gel 1 a catalyst is in the order of 2≫3>4, the substrate specificity of which is in contrast to the almost non‐specificity with the non‐gelled catalyst 1 b bearing butanoyl functionalities, and entirely inverse specificity with a flavin‐dendrimer association catalyst (2<3<4). Based on kinetic studies, the aggregation effects on the substrate specificity have been ascribed to the specific inclusion of aliphatic olefins into the enzyme‐like artificial cavities of the gel catalysts.
From a Molecular Single‐Source Precursor to a Selective High‐Performance RhMnOx Catalyst for the Conversion of Syngas to Ethanol
Authors: Preikschas Phil , Bauer Julia , Huang Xing , Yao Shenglai , Naumann d'Alnoncourt Raoul , Kraehnert Ralph , Trunschke Annette , Rosowski Frank , Driess Matthias 
Published: December 2018

AbstractThe first molecular carbonyl RhMn cluster Na2[Rh3Mn3(CO)18] 2 with highly labile CO ligands and predefined Rh‐Mn bonds could be realized and successfully used for the preparation of the silica (davisil)‐supported RhMnOx catalysts for the conversion of syngas (CO, H2) to ethanol (StE); it has been synthesized through the salt metathesis reaction of RhCl3 with Na[Mn(CO)5] 1 and isolated in 49 % yields. The dianionic Rh3Mn3 cluster core of 2 acts as a molecular single‐source precursor (SSP) for the low‐temperature preparation of selective high‐performance RhMnOx catalysts. Impregnation of 2 on silica (davisil) led to three different silica‐supported RhMnOx catalysts with dispersed Rh nanoparticles tightly surrounded by a MnOx matrix. By using this molecular SSP approach, Rh and MnOx are located in close proximity on the oxide support. Therefore, the number of tilted CO adsorption sites at the RhMnOx interface increased leading to a significant enhancement in selectivity and performance. Investigations on the spent catalysts after several hours time‐on‐stream revealed the influence of rhodium carbide RhCx formation on the long‐term stability.
A Green Multifunctional Antiscaling Inhibitor for Crystallization Control of Ca‐Scale Crystals
Authors: Chen Jianxin , Xu Hao , Han Jian , Wang Cai , Wu Qing , Li Chunli 
Published: December 2018

AbstractHistidine‐polyaspartic acid (His‐PASP), an effective antiscaling inhibitor, was synthesized by polysuccinimide (PSI) and histidine. His‐PASP exhibited a promising antiscaling property by inhibiting the reaction crystallization of Ca‐scale crystals. The crystal form and surface morphology of Ca‐scale crystals were changed after the addition of His‐PASP. The hard scale was turned into soft dirt and can be easily washed away. The binding between His‐PASP and calcite was exothermic and the energy was higher than the traditional adsorption energy. His‐PASP possessed a favorable anticorrosion efficiency for carbon steel in cooling water. In the test of dispersing Fe2O3, the transmittance of the supernatant was reduced with increasing His‐PASP dosage.
Entwicklung eines Partikelmesssystems zur Erfassung geringer Streulicht‐Intensitäten optimiert für den Einsatz sehr schwacher Laserstrahlen
Authors: Teumer Tobias , Hufnagel Thomas , Schäfer Thomas , Schlarp‐Horvath Robert , Karbstein Heike P. , Methner Frank‐Jürgen , Rädle Matthias 
Published: December 2018

AbstractIn dieser Arbeit wird die Möglichkeit aufgezeigt, mithilfe einer sehr empfindlichen Einzel‐Photonenmesstechnik Streulicht von Partikeln zu messen, das durch den Einsatz von Lasern mit extrem geringen Laserintensitäten erzeugt wurde. Die entstehenden Vorteile für nach diesem Prinzip zu bauende Geräte liegen im Bereich Explosionsschutz, Vermeidung von Produktschädigungen und Arbeitssicherheit. Es werden Messaufbauten zum Vermessen von Suspensionen und Aerosolen beschrieben. Laserleistungen kleiner 5 µW werden eingesetzt. Die Messungen beginnen ab einer Partikelgröße von 200 nm und werden in einer 90°‐Anordnung als worst case durchgeführt, da bei diesem Winkel ein Minimum an Streuung vorliegt.
Alkaline‐ionic liquid slug injection for improved heavy oil recovery
Authors: Tunnish Ahmed , Shirif Ezeddin , Henni Amr 
Published: December 2018

AbstractChemical flooding has a great potential for improving the recovery factor of heavy oil, especially for reservoirs in which thermal techniques are not applicable. In this novel study, chemical flooding experiments of alkali and alkali + ionic liquid (AIL) mixtures were performed using unconsolidated sand packs. The aim was to investigate the effect on the recovery factor (RF) of combining an alkali, Na2CO3, and four different imidazolium‐based ionic liquids (1‐ethyl‐3‐methylimidazolium acetate [EMIM][Ac], 1‐ethyl‐3‐methyl imidazolium chloride [EMIM][Cl], 1‐butyl‐3‐methylimidazolium bis(trifluoromethylsulphonyl)imide [BMIM][Tf2N], and 1‐dodecyl‐3‐methylimidazolium chloride [DMIM][Cl]). The obtained data show that as the ionic liquid concentration and slug size increase, the recovery factor (RF) was found to increase. The study also demonstrates that ionic liquids (ILs) are better in improving heavy oil than recovery than a well‐known surfactant, sodium dodecyl sulphate (SDS). IFT measurements were performed for the Pelican oil used with brine and with [DMIM][Cl], and [EMIM][Ac]. The surface tension (SFT) and zeta potential (ZP) were also measured and correlated to the improvement in the RF. The study shows that in the presence of Na2CO3, the ionic liquid type, concentration, and slug size are important parameters in enhancing heavy oil recovery.
Early surveillance is associated with less incidence and severity of breast cancer–related lymphedema compared with a traditional referral model of care
Authors: Koelmeyer Louise A. , Borotkanics Robert J. , Alcorso Jessica , Prah Philip , Winch Caleb J. , Nakhel Kristine , Dean Catherine M. , Boyages John 
Published: December 2018

BackgroundBioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer‐related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer‐related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral model of care.MethodsIn a retrospective analysis of data from 753 women who underwent BIS measures between January 1, 2007 and December 31, 2016, 188 women were assigned to the “early surveillance” group if they began lymphedema monitoring presurgery (n = 121) or within 90 days postsurgery (n = 67), and 285 women were assigned to the “traditional referral” group if they began monitoring after 90 days postsurgery. Health service metrics were calculated as the time to the first BIS measure after 90 days postsurgery, the median follow‐up, and the number of health care visits. Lymphedema was diagnosed based on BIS measures.ResultsWomen in the early surveillance group received lymphedema care significantly earlier than those in the traditional referral group. However, there was no difference in the number of visits per year to the clinic between groups. Significantly more women in the traditional referral group were diagnosed with clinical lymphedema (stage I‐III, 39 % vs 14%; P < .001) and with greater severity (stage II‐III, 24%) compared with those in the early surveillance group (4%).ConclusionsThe current findings support the adoption of an early prospective surveillance model of care using BIS for the early detection and management of breast cancer–related lymphedema.
Modification of Carbon Fibre Surfaces by Sulfur‐Fluoride Exchange Click Chemistry
Authors: Randall James D. , Eyckens Daniel J. , Stojcevski Filip , Francis Paul S. , Doeven Egan H. , Barlow Anders J. , Barrow Andrew S. , Arnold Chantelle L. , Moses John E. , Henderson Luke C. 
Published: December 2018

AbstractThe front cover artwork is provided by the groups of Prof. Luke Henderson (Deakin University) and Prof. John E. Moses (La Trobe University). Read the full text of the Communication at 10.1002/cphc.201800789.
Self‐Assembly of Board‐Shaped Diketopyrrolopyrrole and Isoindigo Mesogens into Columnar π‐π Stacks
Authors: Taing Hi , Cassar Adam Michael , Ocheje Michael Udunyi , Rondeau‐Gagné Simon , El‐Assaad Tarek H. , Sharabati Christa A. , Kaafarani Bilal R. , Eichhorn S. Holger 
Published: December 2018

AbstractDiketopyrrolopyrrole and isoindigo are commercially important dyes that have recently found broad application as electron acceptor and light‐absorbing groups in organic semiconductors. Their self‐assembly into specific supramolecular structures to control optoelectronic properties has been hampered by limited options for substitution and their high propensity for crystallization. Reported here is a molecular design that directs self‐assembly into previously elusive columnar mesophases of π‐π stacking cores. Although attachment of bis(trisoctyloxyphenyl)‐1,3,5‐triazine groups to both ends of diketopyrrolopyrrole‐thiophene and isoindigo cores generated mesomorphic dyes of similar overall shapes and dimensions, distinct differences in their mesomorphism and optoelectronic properties were observed.
Exploiting the Ring Strain of Diphosphetanes: A Synthetic and Computational Approach towards 1,2,5‐Selenadiphospholanes
Authors: Coburger Peter , Aures Richard , Schulz Paulina , Hey‐Hawkins Evamarie 
Published: December 2018

AbstractInvited for this month's cover is the group of Prof. Evamarie Hey‐Hawkins from Leipzig University, Germany. The cover picture, designed by Dr. Christoph Selg, shows two pots on a crowded table planted with bulky tert‐butyl groups symbolizing the phosphorus atoms in the strained ring system of a carborane‐substituted 1,2‐diphosphetane. However, selenium can still be inserted into the P−P bond, as reported by Hey‐Hawkins et al. in their present publication, which combines experimental and computational studies. Read the full text of the article at 10.1002/cplu.201800391.
Chemiexcitation without the Peroxide Bond? Replacing Oxygen with other Heteroatoms
Authors: Fdez. Galván Ignacio , Gustafsson Hannes , Vacher Morgane 
Published: December 2018

AbstractChemiexcitation is the population of electronic excited states from the electronic ground state via radiationless non‐adiabatic transitions upon thermal activation. The subsequent emission of the excess of energy in the form of light is called chemiluminescence or bioluminescence when occurring in living organisms. Key intermediates in these reactions have been shown to contain a high‐energy (often cyclic) peroxide which decomposes. The simplest molecules, 1,2‐dioxetane and 1,2‐dioxetanone, have thus been used extensively both theoretically and experimentally as model systems to understand the underlying mechanisms of chemiexcitation. An outstanding question remains whether the peroxide bond is a necessity and whether equivalent processes could happen in other simple molecules not containing an O−O bond. In the present work, the decomposition reactions of four analogs of 1,2‐dioxetane not containing a peroxide bond, the 1,2‐oxazetidine anion, the 1,2‐diazetidine anion, (neutral) 1,2‐oxazetidine and 1,2‐dithietane, have been studied theoretically using ab initio multiconfigurational methods. In particular, the reaction energy barriers and spin‐orbit coupling strengths were calculated; the electronic degeneracy was studied and compared to the case of 1,2‐dioxetane to assess the potentiality of chemiexcitation in the analog molecules.
Long Wavelength Light Activated Prodrug Conjugates for Biomedical Applications
Authors: Hou Yutong , Zhou Zhiguo , Huang Kai , Yang Hong , Han Gang 
Published: December 2018

AbstractThe front cover artwork is provided by groups of Hong Yang and Gang Han at the College of Chemistry and Materials Science at Shanghai Normal University (China) and the Department of Biochemistry and Molecular Pharmacology at UMass Medical School (United States). The image shows a purple sphere transducer linked with a non‐active prodrug by photosensitive linkers. Upon irradiation with long‐wavelength light, the transducer converts the incident light to short wavelength emission to cleave the photocleavable linkers and trigger drug release. Read the full text of the Minireview, in which such developments in light‐activated prodrugs for biomedical application are reviewed, at10.1002/cptc.201800147.