bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of nasal functions and their relationship with cholesteatoma formation in patients with unilateral chronic otitis media
Authors: Arslan F , Binar M , Aydin U 
Published: October 2018

AbstractObjectivesTo evaluate the nasal functions of patients with unilateral chronic otitis media using rhinomanometry, comparing chronic otitis media sides with healthy sides, chronic otitis media patients with cholesteatoma and without cholesteatoma, and patients with healthy individuals.MethodsThis prospective study included 102 patients with unilateral chronic otitis media (48 with and 54 without cholesteatoma). The control group comprised 40 individuals without any ear or nasal pathologies. All patients underwent active anterior rhinomanometry to measure nasal airway resistance and a saccharin test to measure mucociliary transport times.ResultsThere were no significant differences in nasal airway resistance and mucociliary transport time between the chronic otitis media sides and unaffected sides in the 102 patients (p = 0.72 and p = 0.28, respectively), between the non-suppurative chronic otitis media patients (without cholesteatoma) and chronic otitis media with cholesteatoma patients (p > 0.05), or between the study and control groups (p > 0.05).ConclusionThe present study, with a larger sample size compared to previously published literature, supports the conclusion that unilateral nasal obstruction is unlikely to lead to chronic otitis media on the same side. The results also suggest that nasal functions do not contribute to the development of cholesteatoma.
President Donald Trump as global health’s displacement activity
Authors: Harman Sophie , Davies Sara E. 
Published: October 2018

AbstractThe United States presidential election of Donald Trump in 2016 was observed by global health commentators as posing dire consequences for the progress made in global health outcomes, governance, and financing. This article shares these concerns, however, we present a more nuanced picture of the global health governance progress narrative pre-Trump. We argue that Trump’s presidency is a displacement activity to which global health’s pre-existing inequalities and problems of global health security, financing, and reproductive health can be attributed. Unfettered access to sexual and reproductive rights, sustained financing of health system strengthening initiatives, affordable medicines and vaccines, and a human security-centred definition of global health security were already problematic shortfalls for global health governance. Trump no doubt exacerbates these concerns, however, to blame his presidency for failings in these areas ignores the issues that have been endemic to global health governance prior to his presidency. Instead of using Trump as a displacement activity, his presidency could be an opportunity to confront dependency on US financing model, the lack of a human-security centred definition of global health security, and the norm of restricting reproductive health. It is such engagement and confrontation with these issues that could see Trump’s presidency as being a catalyst for change rather than displacement as a means of preserving the uncomfortable status quo in global health. We make this argument by focusing on three specific areas of US-led global health governance: reproductive health and the ‘global gag rule’, health financing and the President’s Emergency Plan for AIDS Relief (PEPFAR), and pandemic preparedness and global health security.
Depression et Maladie de Parkinson: étude d’une série de 135 parkinsoniens
Authors: Anguenot A. , Loll P.Y. , Neau J.P. , Ingrand P. , Gil R. 
Published: October 2018

Résumé:Objective:La fréquence de la dépression au cours de la maladie de Parkinson (MP) conduit à s’interroger sur les difficultés du diagnostic et sur les liens entre la dépression et l’histoire naturelle de la maladie.Méthodes:Une série consécutive de 135 sujets atteints d’une MPidiopathique a été examinée sur le plan psychiatrique (DSM-III-R, échelle de dépression de Goldberg), neurologique (en distinguant les signes “axiaux” des autres signes parkinsoniens), neuropsychologique ( et en particulier tests frontaux).Résultats:Plus de la moitié des sujets ont une dépression qui apparaît plus fréquente dans les formes akinétiques et les formes fluctuantes de la maladie. Les sujets déprimés n’ont pas de déficit cognitif plus marqué mais leurs scores aux tests frontaux sont plus élevés. En outre les signes axiaux de la maladie (instabilité posturale, rigidité axiale) sont plus marqués chez les parkinsoniens déprimés, suggérant un lien entre la dépression et les lésions non dopaminergiques de la maladie. Alors que le ralentissement, les troubles de l’appétit et du sommeil, la fatigue peuvent être observés même chez des parkinsoniens non dépressifs, la séparation de la population parkinsonienne en plusieurs groupes montre que certains symptômes ne sont jamais rencontrés chez les parkinsoniens non dépressifs: il en est ainsi apparu que “l’impression que la vie ne vaut pas la peine d’être vécue”, “la perte d’espoir pour l’avenir”, “l’impression de ne pas être à la hauteur, de ne rien faire de bien”, “la baisse d’énergie”, “la tristesse matinale” caractérisent la dépression parkinsonienne. La dépression parkinsonienne revêt deux grandes formes cliniques. La première est la plus riche en manifestations somatiques: troubles du sommeil, fatigue matinale; elle correspond aux dépressions les plus sévères avec une absence d’espoir pour l’avenir , une perte de confiance en soi. La seconde est pauvre en manifestations somatiques alors que l’apathie y est très fréquente ainsi que le ralentissement.Conclusions:Cette étude permet ainsi de préciser les symptômes de la dépression parkinsonienne qui doit être mieux reconnue pour être plus souvent traitée. Les liens entre la dépression et les signes axiaux de la maladie expliquent sans doute pourquoi la L-dopa et les agonistes dopaminergiques améliorent les signes moteurs de la dépression sans agir le plus souvent sur les manifestations dépressives.
Cortical Location of Benign Paroxysmal Rhythms in the Electrocorticogram
Authors: McLachlan Richard S. , Lubus Neda 
Published: October 2018

Abstract:Background:Six/second spike waves, 14 and 6/second positive spikes and small sharp spikes are apiculate paroxysmal rhythms in the electroencephalogram, thought to be of no diagnostic importance. The cortical origin of these discharges is documented in this report.Methods:These waveforms were assessed in recordings from the surface of the cerebral cortex using implanted subdural electrodes in 61 patients monitored for possible epilepsy surgery.Results:Eight patients had 6/second spike wave, four had 14 and 6/second positive spikes and 3 had small sharp spikes. The 6/second spike waves were localised to the posterior cingulate gyrus, a more restricted region than would be predicted from scalp recordings and the 14 and 6/second spikes to the posterior mesial temporal cortex. Small sharp spikes were more widely distributed but also predominated in the posterior mesial temporal area. None of the discharges were congruent with the focus of seizure origin and no interaction with other interictal spikes was found.Conclusions:These benign paroxysmal rhythms can appear incidentally in the electrocorticograms of patients with focal epilepsy and should not be confused with focal pathological spike activity or considered to be of any value in localizing the seizure focus.
Petrous Apex Granulomas: CT and MR Imaging
Authors: Hentschel Stephen , Durity Felix 
Published: October 2018

A 29-year-old male complained of a four month history of horizontal, spontaneous, and nonprogressive diplopia. On examination he had a mild left sixth nerve palsy. The rest of his general and neurologic examinations were normal.Computed tomography scanning demonstrated a nonenhancing, well-circumscribed, lesion in the left petrous apex (Figure 1). The opposite apex was well pneumatized. The lesion abutted the medial wall of the horizontal canal of the internal carotid artery and pointed towards the lateral wall of the sphenoid sinus. Unfortunately, CT bone windows were not available for this case but would have been helpful in terms of the differential diagnosis. An MRI demonstrated a predominantly high signal mass on T1 and T2 sequences (Figure 2). The diagnosis was a petrous apex granuloma.
Demander de l'aide à la permanence d'accès aux droits d'un centre social: modalités de construction des requêtes
Authors: TRAVERSO VÉRONIQUE 
Published: October 2018

RÉSUMÉL'article porte sur la formulation des demandes des usagers dans une permanence d'accès au droit dans un centre social en France. Il se concentre sur les usagers habituels, dont certains sont peu francophones, et met en évidence des procédés spécifiques par rapport aux descriptions existantes de la formulation des requêtes en français. L'article se situe dans une approche de linguistique interactionnelle multimodale, à partir de laquelle est décrite la construction progressive et collaborative des demandes et la variété des ressources, y compris gestuelles, utilisées par les usagers pour les formuler. L'objectif est, d'une part, d'examiner l'influence de la formulation de la requête sur le traitement qui en est fait par la médiatrice. C'est, d'autre part, de mettre en évidence les ressources privilégiées par les demandeurs.
Life-course BMI and biomarkers in persons aged 60 years or older: a comparison of the USA and Costa Rica
Authors: Rehkopf David H , Duong Andrew , Dow William H , Rosero-Bixby Luis 
Published: October 2018

AbstractObjectiveThere is a large literature linking current BMI to levels of cardiovascular risk biomarkers, but it is unknown whether measures of BMI earlier in the life course and maximum BMI are predictive of current levels of biomarkers. The objective of the current study was to determine how current, maximum and age-25 BMI among individuals over the age of 60 years are associated with their current levels of cardiovascular risk biomarkers.DesignCross-sectional study with retrospective recall.SettingCosta Rica (n 821) and the USA (n 4110).SubjectsNationally representative samples of adults aged 60 years or over.ResultsWe used regression models to examine the relationship between multiple meaures of BMI with four established cardiovascular risk biomarkers. The most consistent predictor of current levels of systolic blood pressure, TAG and HDL-cholesterol was current BMI. However, maximum BMI was the strongest predictor of glycosylated Hb (HbA1c) and was also related to HDL-cholesterol and TAG. HbA1c was independent of current BMI. We found that these relationships are consistent between Costa Rica and the USA for HbA1c and for HDL-cholesterol.ConclusionsCurrent levels of cardiovascular risk biomarkers are not only the product of current levels of BMI, but also of maximum lifetime BMI, particularly for levels of HbA1c and for HDL-cholesterol. Managing maximum obtained BMI over the life course may be most critical for maintaining the healthiest levels of cardiovascular risk.
Early evolution of purple retinal pigments on Earth and implications for exoplanet biosignatures
Authors: DasSarma Shiladitya , Schwieterman Edward W. 
Published: October 2018

AbstractWe propose that retinal-based phototrophy arose early in the evolution of life on Earth, profoundly impacting the development of photosynthesis and creating implications for the search for life beyond our planet. While the early evolutionary history of phototrophy is largely in the realm of the unknown, the onset of oxygenic photosynthesis in primitive cyanobacteria significantly altered the Earth's atmosphere by contributing to the rise of oxygen ~2.3 billion years ago. However, photosynthetic chlorophyll and bacterio chlorophyll pigments lack appreciable absorption at wavelengths about 500–600 nm, an energy-rich region of the solar spectrum. By contrast, simpler retinal-based light-harvesting systems such as the haloarchaeal purple membrane protein bacteriorhodopsin show a strong well-defined peak of absorbance centred at 568 nm, which is complementary to that of chlorophyll pigments. We propose a scenario where simple retinal-based light-harvesting systems like that of the purple chromoprotein bacteriorhodopsin, originally discovered in halophilic Archaea, may have dominated prior to the development of photosynthesis. We explore this hypothesis, termed the ‘Purple Earth,’ and discuss how retinal photopigments may serve as remote biosignatures for exoplanet research.
Culturally adapted Family Intervention (CaFI): case examples from therapists’ perspectives
Authors: Berry Katherine , Day Christine , Mulligan Lee D. , Seed Tara , Degnan Amy , Edge Dawn 
Published: October 2018

AbstractThis paper describes three case examples from a recent trial of family intervention specifically designed for people of African-Caribbean descent. These examples, told from the therapists’ perspectives, highlight key components of the intervention and issues that arose in working with this client group. Findings from the study suggest that it is possible to engage this client-group in family therapy similar to traditional evidenced-based family interventions, although as illustrated in the paper, it is important that therapists pay attention to themes that are likely to be particularly pertinent for this group, including experiences of discrimination and mistrust of services. The use of Family Support Members, consisting of members of the person's care team or volunteers recruited from the community, may also help support people to engage in therapy in the absence of biological relatives.
ENSO's Shrinking Twentieth‐Century Footprint Revealed in a Half‐Millennium Coral Core From the South Pacific Convergence Zone
Authors: Tangri N. , Dunbar R. B. , Linsley B. K. , Mucciarone D. M. 
Published: October 2018

AbstractA 492‐year‐long, continuous δ18O time series from a massive Porites coral colony in Ta'u, American Samoa, records contrasting responses to different types of El Niño‐Southern Oscillation (ENSO) through a mixed sea surface temperature and salinity signal. Currently, conventional El Niño (La Niña) events generate cold and salty (warm and fresh) anomalies at Ta'u, while Modoki El Niño (La Niña) events warm (cool) the waters at Ta'u. Over the course of the twentieth century, the Ta'u δ18O record underwent a polarity shift in its response to conventional ENSO: A warm and fresh (cool and salty) response to El Niño (La Niña) was replaced by the opposite pattern. We interpret this as evidence for the movement of the Eastern Pacific ENSO null zone, the narrow band of the surface ocean where sea surface temperature variability is not on average correlated with ENSO. This movement appears to be related to overall shrinking of the ENSO footprint over the twentieth century. We infer no such trend in the Modoki footprint. The five‐century‐long Ta'u record shows dramatic, century‐scale changes in ENSO‐band variability. Comparisons with other ENSO reconstructions lead to conflicting interpretations: The Ta'u coral may have recorded changes in the strength of ENSO or in its spatial footprint. Changes in the spatial footprint manifest as a changing sensitivity to ENSO at any given location, presenting challenges to established methods of ENSO reconstruction.
Seston Fatty Acid Responses to Physicochemical Changes in Subalpine Lake Lunz, Austria
Authors: Rasconi S. , Ptacnik R. , Kainz M. J. 
Published: October 2018

AbstractRapid increase in lake temperature can cause a shift toward the dominance of warm temperature tolerant species, including Cyanobacteria that are deficient in polyunsaturated fatty acids (PUFA) supporting consumer growth and reproduction. To increase our understanding of how changes in physicochemical lake parameters affect phytoplankton composition and the provision of dietary quality to consumers in subalpine oligotrophic lakes, we conducted a multiannual study (2013–2015) in the 34‐m‐deep Lake Lunz and investigated interannual changes in (a) water temperature, transparency, and lake inflow; (b) seston (<30‐μm particle size class) biomass and taxonomy; and (c) seston nutritional quality, assessed by its PUFA composition. The phytoplankton taxonomic composition within this seston size class varied mostly by changes in physical parameters (temperature, conductivity, lake transparency, and days of full ice cover). The dietary quality of seston varied mostly with lake physical parameters and, to a lesser extent, with phytoplankton taxonomic composition, suggesting that the nutritional quality at the base of the food web in Lake Lunz is likely to respond directly to changes in lake physical parameters. This multiannual data set, combining monthly values for physicochemical variables, grazable phytoplankton composition, and fatty acids in seston, provides nutritional information of how annual weather changes may induce changes at the base of the food web in this and perhaps also other oligotrophic subalpine lakes.
Noble Gases in Deepwater Oils of the U.S. Gulf of Mexico
Authors: Barry P. H. , Lawson M. , Meurer W. P. , Cheng A. , Ballentine C. J. 
Published: October 2018

AbstractHydrocarbon migration and emplacement processes remain underconstrained despite the vast potential economic value associated with oil and gas. Noble gases provide information about hydrocarbon generation, fluid migration pathways, reservoir conditions, and the relative volumes of oil versus water in the subsurface. Produced gas He‐Ne‐Ar‐Kr‐Xe data from two distinct oil fields in the Gulf of Mexico (Genesis and Hoover‐Diana) are used to calibrate a model that takes into account both water‐oil solubility exchange and subsequent gas cap formation. Reconstructed noble gas signatures in oils reflect simple (two‐phase) oil‐water exchange imparted during migration from the source rock to the trap, which are subsequently modified by gas cap formation at current reservoir conditions. Calculated, oil to water volume ratios (
) in Tertiary‐sourced oils from the Hoover‐Diana system are 2–3 times greater on average than those in the Jurassic sourced oils from the Genesis reservoirs. Higher
in Hoover‐Diana versus Genesis can be interpreted in two ways: either (1) the Hoover reservoir interval has 2–3 times more oil than any of the individual Genesis reservoirs, which is consistent with independent estimates of oil in place for the respective reservoirs, or (2) Genesis oils have experienced longer migration pathways than Hoover‐Diana oils and thus have interacted with more water. The ability to determine a robust
, despite gas cap formation and possible gas cap loss, is extremely powerful. For example, when volumetric hydrocarbon ratios are combined with independent estimates of hydrocarbon migration distance and/or formation fluid volumes, this technique has the potential to differentiate between large and small oil accumulations.
Induced Seismicity in Western Canada Linked to Tectonic Strain Rate: Implications for Regional Seismic Hazard
Authors: Kao Honn , Hyndman Roy , Jiang Yan , Visser Ryan , Smith Brindley , Babaie Mahani Alireza , Leonard Lucinda , Ghofrani Hadi , He Jiangheng 
Published: October 2018

AbstractA rapid increase of injection‐induced earthquakes (IIE) is often linked to a higher level of seismic hazard. In this study, we compare the geodetically defined moment rate to seismicity distribution in western Canada where significant IIE are observed. The regional seismic pattern is dominated by IIE, both in number and moment, along a 150‐km wide NW‐SE band of moderate strain rate in the easternmost Cordillera and foothills. The observed rate of moment release from local earthquakes is much closer to the tectonic moment rate in the IIE‐dominated areas. We conclude that, on a regional scale, tectonic strain rate is an important control on IIE. Injection in areas with moderate tectonic strain may temporarily increase the local seismic hazard, but widespread IIE over an extended period of time may deplete the available tectonic moment and could, under the right conditions, have a limited long‐term effect of reducing regional seismic hazard.
ENSO Change in Climate Projections: Forced Response or Internal Variability?
Authors: Maher N. , Matei D. , Milinski S. , Marotzke J. 
Published: October 2018

AbstractTwo large ensembles are used to quantify the extent to which internal variability can contribute to long‐term changes in El Niño‐Southern Oscillation (ENSO) characteristics. We diagnose changes that are externally forced and distinguish between multi‐model simulation results that differ by chance and those that differ due to different model physics. The range of simulated ENSO amplitude changes in the large ensemble historical simulations encompasses 90% of the Coupled Model Intercomparison Project 5 historical simulations and 80% of moderate (RCP4.5) and strong (RCP8.5) warming scenarios. When considering projected ENSO pattern changes, model differences are also important. We find that ENSO has high internal variability and that single realizations of a model can produce very different results to the ensemble mean response. Due to this variability, 30–40 ensemble members of a single model are needed to robustly compute absolute ENSO variance to a 10% error when 30‐year analysis periods are used.
Observational Evidence of Large‐Scale Multiple Reconnection at the Earth's Dayside Magnetopause
Authors: Fuselier S. A. , Petrinec S. M. , Trattner K. J. , Broll J. M. , Burch J. L. , Giles B. L. , Strangeway R. J. , Russell C. T. , Lavraud B. , Øieroset M. , Torbert R. B. , Farrugia C. J. , Vines S. K. , Gomez R. G. , Mukherjee J. , Cassak P. A. 
Published: October 2018

AbstractMagnetic flux ropes of various scale sizes have been observed at the Earth's magnetopause for four decades. These multiple structures resulting from reconnection have complex internal field and plasma signatures, and evolve as they propagate along the dayside magnetopause. Here plasma and magnetic field observations from the Magnetospheric Multiscale (MMS) mission are used to describe a different type of large‐scale multiple reconnection, magnetic flux rope‐like structure at the Earth's magnetopause. These observations show at least two X lines separated by many Earth radii. Unlike smaller‐scale flux ropes or flux transfer events, these multiple X lines are stationary and consist of primary and secondary X lines. The secondary X line is either transient in time or does not reconnect all of the magnetic flux that reconnects at the primary X line. Several examples of these large‐scale reconnection structures are tabulated. These examples indicate that this type of structure may be common at the magnetopause at least for a narrow range of interplanetary magnetic field clock angles.
Evolution of the Auroral Signatures of Jupiter's Magnetospheric Injections
Authors: Dumont M. , Grodent D. , Radioti A. , Bonfond B. , Roussos E. , Paranicas C. 
Published: October 2018

AbstractAuroral emissions equatorward of the main emission at Jupiter are suggested to reflect the dynamics of the plasma in the middle magnetosphere. Here we examine the motion of the auroral signatures of magnetospheric injections appearing in Hubble Space Telescope (HST) images. Our results suggest that the injected plasma moves planetward and lags behind corotation. We then compare the characteristics of the observed signatures with simulations of the auroral precipitation related to injections due to pitch angle scattering. These results indicate that the lifetime of the auroral structures lies between a half and a full rotation of Jupiter. Ultraviolet spectrally resolved images acquired with HST are then used to highlight the energy‐dependent drift of the electrons in auroral injection signatures. Comparison of these observations with simulations of the energy‐dependent drift of injected particles suggests that these structures are ~3‐hr old. Finally, we extend our investigations toward larger and less structured outer emissions possibly associated with younger plasma injections. The motion and evolution of these features are similar to those of the small and compact ones considered in the first part of the study.