bluuebunny/crossref_metadata_2025_split huggingface dataset:
iTRAQ‐based proteomic and bioinformatic characterization of human mast cells upon infection by the influenza A virus strains H1N1 and H5N1
Authors: Wu Hongping , Zhang Shouping , Huo Caiyun , Zou Shumei , Lian Zhengxing , Hu Yanxin 
Published: July 2019

Mast cells can support the replication of influenza A virus, although how this occurs is poorly understood. In the present study, using quantitative MS, we analyzed the proteome of human mast cells infected with different influenza A virus strains at 12 h post‐infection. Forty‐one differentially expressed proteins were identified in human mast cells upon infection by the virulent H5N1 (A/Chicken/Henan/1/04) virus compared to the seasonal H1N1 (A/WSN/33) virus. Bioinformatic analyses confirmed that H1N1 significantly regulates the RNA degradation pathway via up‐regulation of CCR4‐NOT transcription complex subunit 4, whereas apoptosis could be suppressed by H5N1 via down‐regulation of the tumor protein p53 signaling pathway with P ≤ 0.05 at 12 h post‐infection. The hypoxia‐inducible factor‐1 signaling pathway of human mast cells is more susceptible to infection by H5N1 than by H1N1 virus.
Ultrathin Highly Luminescent Two‐Monolayer Colloidal CdSe Nanoplatelets
Authors: Delikanli Savas , Yu Guannan , Yeltik Aydan , Bose Sumanta , Erdem Talha , Yu Junhong , Erdem Onur , Sharma Manoj , Sharma Vijay Kumar , Quliyeva Ulviyya , Shendre Sushant , Dang Cuong , Zhang Dao Hua , Sum Tze Chien , Fan Weijun , Demir Hilmi Volkan 
Published: July 2019

AbstractSurface effects in atomically flat colloidal CdSe nanoplatelets (NLPs) are significantly and increasingly important with their thickness being reduced to subnanometer level, generating strong surface related deep trap photoluminescence emission alongside the bandedge emission. Herein, colloidal synthesis of highly luminescent two‐monolayer (2ML) CdSe NPLs and a systematic investigation of carrier dynamics in these NPLs exhibiting broad photoluminescence emission covering the visible region with quantum yields reaching 90% in solution and 85% in a polymer matrix is shown. The astonishingly efficient Stokes‐shifted broadband photoluminescence (PL) emission with a lifetime of ≈100 ns and the extremely short PL lifetime of around 0.16 ns at the bandedge signify the participation of radiative midgap surface centers in the recombination process associated with the underpassivated Se sites. Also, a proof‐of‐concept hybrid LED employing 2ML CdSe NPLs is developed as color converters, which exhibits luminous efficacy reaching 300 lm Wopt−1. The intrinsic absorption of the 2ML CdSe NPLs (≈2.15 × 106 cm−1) reported in this study is significantly larger than that of CdSe quantum dots (≈2.8 × 105 cm−1) at their first exciton signifying the presence of giant oscillator strength and hence making them favorable candidates for next‐generation light‐emitting and light‐harvesting applications.
Alginate Encapsulation of Bioengineered Protein‐Coated Polyhydroxybutyrate Particles: A New Platform for Multifunctional Composite Materials
Authors: Ogura Kampachiro , Rehm Bernd H. A. 
Published: July 2019

AbstractImmobilization and display of proteins is extensively used to enhance stability and performance of proteins for technical uses such as in biotechnology. Here, self‐assembled nonporous polyhydroxybutyrate (PHB) particles bioengineered to display proteins of interest are subjected to alginate encapsulation processes. The novel composite spheres are fabricated using ionotropic gelation methods. The immunoglobulin G (IgG) binding domain Z and organophosphate hydrolase (OpdA) are attached to PHB particles, and are examples for bioseparation and bioremediation applications, respectively. Alginate microspheres entrapping Z domain coated PHB particles enable flow‐through purification of IgG. Microsphere porosity is pH tunable and at acidic pH IgG is released from Z domains but retained within microspheres. OpdA‐PHB particles are functionally entrapped in alginate microspheres enabling flow‐through substrate conversion. Attachment of functional proteins to PHB particles enhances retention within the alginate microspheres. The hydrophobic PHB particle core within alginate beads provides payload for lipophilic substances, which adsorption kinetics are aligned with a pseudo‐second‐order kinetic model in agreement with the Freundlich isotherm model. This study describes the development of a multifunctional composite material platform based on alginate spheres encapsulating PHB particles that provide payload for lipophilic substances and can be engineered to display protein functions of interest.
Water‐Resistant and Flexible Perovskite Solar Cells via a Glued Interfacial Layer
Authors: Huang Zengqi , Hu Xiaotian , Liu Cong , Meng Xiangchuan , Huang Zhandong , Yang Jia , Duan Xiaopeng , Long Juan , Zhao Zhipeng , Tan Licheng , Song Yanlin , Chen Yiwang 
Published: July 2019

AbstractPerovskite solar cells (PVSCs) are promising photovoltaic technologies for realizing power sources with outstanding power conversion efficiency (PCE) and low‐cost properties. However, the extraordinary photovoltaic performance can be maximized only if an extremely stabilized device structure is developed. Here, a novel glued poly(ethylene‐co‐vinyl acetate) (EVA) interfacial layer is introduced to fabricate highly efficient and stable PVSCs with excellent waterproofness and flexibility. This strategy can effectively passivate the perovskite surface, reduce defect density, and balance charge transfer, which leads to a champion PCE of 19.31% for a 0.1 cm2 device and 11.73% for a 25 cm2 solar module. More importantly, the formation of a glued EVA thin layer on the surface of perovskite can inhibit ionic migration to the Ag electrode, form favorable interfacial contact and adhesive interaction with the perovskite/[6,6]‐phenyl‐C61‐butyric acid methyl ester to sustain mechanical bending, and produce significant waterproofness from moisture invasion, thus facilitating improvement in the operational stability of the PVSCs. The EVA‐treated PVSCs exhibit superior PCE values of 15.12% for a flexible device (0.1 cm2) and 8.95% for a flexible module (25 cm2), as well as over 85% retention after 5000 bending cycles, which opens up a new strategy for the practical application of PVSCs in portable and wearable electronics.
Multiresponsive Elastic Colloidal Crystals for Reversible Structural Color Patterns
Authors: Liao Junlong , Zhu Cun , Gao Bingbing , Zhao Ze , Liu Xiaojiang , Tian Lei , Zeng Yi , Zhou Xinlian , Xie Zhuoying , Gu Zhongze 
Published: July 2019

AbstractMultiresponsive elastic poly(methyl methacrylate‐butyl acrylate) (P(MMA‐BA)) copolymer nanoparticles with controlled sizes are fabricated through a one‐step method, which further serve as building blocks for the construction of multiresponsive films via self‐assembly. Taking advantage of the relatively low glass transition temperature and the core–shell structure of the copolymer nanoparticles, they possess the capacity to partially deform and fuse at room temperature under dry status, eventually resulting in the enhancement of the mechanical properties as well as the control of optical properties in the assembled ordered structures. The generated elastic films not only can control the concealment or exhibition of the designed color information, but also can rapidly respond to external stimuli such as the solvent, pH, and tensile force in a reversible fashion. These functional elastic copolymer nanoparticles have potential applications in dynamic color display, optical sensing, and anticounterfeiting.
Energy‐Mediated Machinery Drives Cellular Mechanical Allostasis
Authors: Wang Qianbin , Qian Weiyi , Xu Xiaoyu , Bajpai Apratim , Guan Kevin , Zhang Zijing , Chen Roy , Flamini Vittoria , Chen Weiqiang 
Published: July 2019

AbstractAllostasis is a fundamental biological process through which living organisms achieve stability via physiological or behavioral changes to protect against internal and external stresses, and ultimately better adapt to the local environment. However, an full understanding of cellular‐level allostasis is far from developed. By employing an integrated micromechanical tool capable of applying controlled mechanical stress on an individual cell and simultaneously reporting dynamic information of subcellular mechanics, individual cell allostasis is observed to occur through a biphasic process; cellular mechanics tends to restore to a stable state through a mechanoadaptative process with excitative biophysical activity followed by a decaying adaptive phase. Based on these observations, it is found that cellular allostasis occurs through a complex balance of subcellular energy and cellular mechanics; upon a transient and local physical stimulation, cells trigger an allostatic state that maximizes energy and overcomes a mechanical “energy barrier” followed by a relaxation state that reaches its mechanobiological stabilization and energy minimization. Discoveries of energy‐driven cellular machinery and conserved mechanotransductive pathways underscore the critical role of force‐sensitive cytoskeleton equilibrium in cellular allostasis. This highlight the biophysical origin of cellular mechanical allostasis, providing subcellular methods to understand the etiology and progression of certain diseases or aging.
Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy
Authors: Zhang Fengrong , Liu Yuehong , Lei Jiani , Wang Shunhao , Ji Xunming , Liu Huiyu , Yang Qi 
Published: July 2019

AbstractAlthough near‐infrared (NIR)‐light‐mediated photothermal thrombolysis has been investigated to overcome the bleeding risk of clinical clot‐busting agents, the secondary embolism of post‐phototherapy fragments (>10 µm) for small vessels should not be ignored in this process. In this study, dual‐modality photothermal/photodynamic thrombolysis is explored using targeting nanoagents with an emphasis on improving biosafety as well as ameliorating the thrombolytic effect. The nanoagents can actively target glycoprotein IIb/IIIa receptors on thrombus to initiate site‐specific thrombolysis by hyperthermia and reactive oxygen species under NIR laser irradiation. In comparison to single photothermal thrombolysis, an 87.9% higher re‐establishment rate of dual‐modality photothermal/photodynamic thrombolysis by one‐time treatment is achieved in a lower limb thrombosis model. The dual‐modality thrombolysis can also avoid re‐embolization after breaking fibrin into tiny fragments. All the results show that this strategy is a safe and validated protocol for thrombolysis, which fits the clinical translational trend of nanomedicine.
A Hollow‐Shell Structured V2O5 Electrode‐Based Symmetric Full Li‐Ion Battery with Highest Capacity
Authors: Wang Chengrui , Zhang Lei , Al‐Mamun Mohammad , Dou Yuhai , Liu Porun , Su Dawei , Wang Guoxiu , Zhang Shanqing , Wang Dan , Zhao Huijun 
Published: July 2019

AbstractThe symmetric batteries with an electrode material possessing dual cathodic and anodic properties are regarded as an ideal battery configuration because of their distinctive advantages over the asymmetric batteries in terms of fabrication process, cost, and safety concerns. However, the development of high‐performance symmetric batteries is highly challenging due to the limited availability of suitable symmetric electrode materials with such properties of highly reversible capacity. Herein, a triple‐hollow‐shell structured V2O5 (THS‐V2O5) symmetric electrode material with a reversible capacity of >400 mAh g−1 between 1.5 and 4.0 V and >600 mAh g−1 between 0.1 and 3.0 V, respectively, when used as the cathode and anode, is reported. The THS‐V2O5 electrodes assembled symmetric full lithium‐ion battery (LIB) exhibits a reversible capacity of ≈290 mAh g−1 between 2 and 4.0 V, the best performed symmetric energy storage systems reported to date. The unique triple‐shell structured electrode makes the symmetric LIB possessing very high initial coulombic efficiency (94.2%), outstanding cycling stability (with 94% capacity retained after 1000 cycles), and excellent rate performance (over 140 mAh g−1 at 1000 mA g−1). The demonstrated approach in this work leaps forward the symmetric LIB performance and paves a way to develop high‐performance symmetric battery electrode materials.
Training in the Management of Psychobehavioral Conditions: A Needs Assessment Survey of Emergency Medicine Residents
Authors: Pickett Jason , Haas Mary Rose Calderone , Fix Megan L. , Tabatabai Ramin R. , Carrick Angela , Robertson Jennifer , Barnes Angelica Veronica , Ondeyka Amy , Brown Mary Jane , Edwards Andrew R. , Dehon Erin 
Published: July 2019

AbstractObjectiveMental health–related ED visits are increasing. Despite this trend, most emergency medicine (EM) residency programs devote little time to psychiatry education. This study aimed to identify EM residents’ perceptions of training needs in emergency psychiatry and self‐confidence in managing patients with psychobehavioral conditions.MethodsA needs assessment survey was distributed to residents at 15 Accreditation Council for Graduate Medical Education–accredited EM programs spanning the U.S. Survey items addressed amount and type of training in psychiatry during residency, perceived training needs in psychiatry, and self‐confidence performing various clinical skills related to emergency psychiatric care. Residents used a 5‐point scale (1 = nothing; 5 = very large amount) to rate their learning needs in a variety of topic areas related to behavioral emergencies (e.g., medically clearing patients, substance use disorders). Using a scale from 0 to 100, residents rated their confidence in their ability to independently perform various clinical skills related to emergency psychiatric care (e.g., differentiating a psychiatric presentation from delirium).ResultsOf the 632 residents invited to participate, 396 (63%) responded. Twelve percent of respondents reported completing a psychiatry rotation during EM residency. One of the 15 participating programs had a required psychiatry rotation. Residents reported that their program used lectures (56%) and/or supervised training in the ED (35%) to teach residents about psychiatric emergencies. Most residents reported minimal involvement in the treatment of patients with psychiatric concerns. The majority of residents (59%) believed that their program should offer more education on managing psychiatric emergencies. Only 14% of residents felt “quite” or “extremely” prepared to treat psychiatric patients. Overall, residents reported the lowest levels of confidence and highest need for more training related to counseling suicidal patients and treating psychiatric issues in special populations (e.g., pregnant women, elderly, and children).ConclusionsMost EM residents desire more training in managing psychiatric emergencies than is currently provided.
Copper(II)‐Catalyzed Aerobic Oxidation of Amines: Divergent Reaction Pathways by Solvent Control to Imines and Nitriles
Authors: Kim Jihyeon , Golime Gangadhararao , Kim Hun Young , Oh Kyungsoo 
Published: July 2019

AbstractThe dehydrogenative coupling of amines by copper catalysts was investigated in the presence of molecular oxygen. By modulating the aerobic oxidation pathways of Cu(OAc)2 catalyst in different reaction solvents, the selective formations of homo‐coupled imines, cross‐coupled imines, and nitriles have been achieved from amine derivatives. The discovery of the multiple aerobic oxidation pathways of Cu(OAc)2 signifies the on demand reactivity control of the catalytically active copper species by the reaction solvents. Given that the aerobic oxidation protocols are of significant interest to the advancement of green chemical processes, the copper‐catalyzed aerobic oxidation reactions will be useful for a wide range of functional group transformations.
On‐Chip Tailorability of Capacitive Gas Sensors Integrated with Metal–Organic Framework Films
Authors: Yuan Hongye , Tao Jifang , Li Nanxi , Karmakar Avishek , Tang Chunhua , Cai Hong , Pennycook Stephen John , Singh Navab , Zhao Dan 
Published: July 2019

AbstractGas sensing technologies for smart cities require miniaturization, cost‐effectiveness, low power consumption, and outstanding sensitivity and selectivity. On‐chip, tailorable capacitive sensors integrated with metal–organic framework (MOF) films are presented, in which abundant coordinatively unsaturated metal sites are available for gas detection. The in situ growth of homogeneous Mg‐MOF‐74 films is realized with an appropriate metal‐to‐ligand ratio. The resultant sensors exhibit selective detection for benzene vapor and carbon dioxide (CO2) at room temperature. Postsynthetic modification of Mg‐MOF‐74 films with ethylenediamine decreases sensitivity toward benzene but increases selectivity to CO2. The reduced porosity and blocked open metal sites caused by amine coordination account for a deterioration in the sensing performance for benzene (by ca. 60 %). The enhanced sensitivity for CO2 (by ca. 25 %) stems from a tailored amine–CO2 interaction. This study demonstrates the feasibility of tuning gas sensing properties by adjusting MOF–analyte interactions, thereby offering new perspectives for the development of MOF‐based sensors.
Rational Design of Crystalline Covalent Organic Frameworks for Efficient CO2 Photoreduction with H2O
Authors: Lu Meng , Liu Jiang , Li Qiang , Zhang Mi , Liu Ming , Wang Jin‐Lan , Yuan Da‐Qiang , Lan Ya‐Qian 
Published: July 2019

AbstractSolar energy‐driven conversion of CO2 into fuels with H2O as a sacrificial agent is a challenging research field in photosynthesis. Herein, a series of crystalline porphyrin‐tetrathiafulvalene covalent organic frameworks (COFs) are synthesized and used as photocatalysts for reducing CO2 with H2O, in the absence of additional photosensitizer, sacrificial agents, and noble metal co‐catalysts. The effective photogenerated electrons transfer from tetrathiafulvalene to porphyrin by covalent bonding, resulting in the separated electrons and holes, respectively, for CO2 reduction and H2O oxidation. By adjusting the band structures of TTCOFs, TTCOF‐Zn achieved the highest photocatalytic CO production of 12.33 μmol with circa 100 % selectivity, along with H2O oxidation to O2. Furthermore, DFT calculations combined with a crystal structure model confirmed the structure–function relationship. Our work provides a new sight for designing more efficient artificial crystalline photocatalysts.
Chemical Composition and Nutritional Information of Fats Used in Fillings of Sandwich Cookies
Authors: da Silva Thais Lomonaco Teodoro , Martini Silvana , Arellano Daniel Barrera 
Published: July 2019

AbstractThe aim of this work was to evaluate the characteristics of fillings used in cookies commercialized in Brazil and in USA according to their chemical composition, labels, nutritional information, ingredients list, and price. Fillings had approximately 25–32% of fat. In general, the composition of these fats consisted of approximately 50% of saturated fatty acids (SFA), mainly palmitic acid, and 50% of unsaturated fatty acids, mainly oleic acid. Brazilian samples had trans‐fatty acids (TFA) in the range of 1–15% although in many cases their presence was not reported in the labels. USA product labels did not present a fixed portion weight but they showed detailed information about the types of fats used such as source and the process used for their production. In 70% of Brazilian product labels, the information shown in the ingredient list was limited to “vegetable fat,” which does not give enough information to consumers about the type of fat used. In addition, our results showed that low‐trans‐products or zero‐trans‐products, in which TFA were replaced by SFA, presented the highest prices. This research suggests that further legislation should be developed in Brazil to decrease the amount of TFA in foods and improve their nutritional properties.
RhCl(TPPTS)3 supported on iota‐carrageenan as recyclable catalysts for Suzuki cross‐coupling
Authors: Leviev Sivan , Wolfson Adi , Levy‐Ontman Oshrat 
Published: July 2019

ABSTRACTA rhodium complex was immobilized for the first time in iota‐carrageenan polysaccharide to render a xerogel catalyst. This new heterogeneous catalyst was successfully used in Suzuki cross‐coupling and was easily separated from the reaction mixture and recycled two times without loss of activity. The rhodium heterogeneous catalyst was characterized by FTIR, SEM‐EDS, and TEM analyses, which demonstrated that the catalyst complex successfully embedded within the polysaccharide and exhibited an unordered, porous structure. Moreover, it was demonstrated that the novel and simple heterogenization procedure, which has been used previously for palladium complexes, is a general route to immobilize transition metal complexes in polysaccharide matrixes. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48200.
Histology of Caenagnathid (Theropoda, Oviraptorosauria) Dentaries and Implications for Development, Ontogenetic Edentulism, and Taxonomy
Authors: Funston Gregory F. , Wilkinson Ryan D. , Simon D. Jade , Leblanc Aaron H. , Wosik Mateusz , Currie Philip J. 
Published: July 2019

ABSTRACTThe fossil record of caenagnathid oviraptorosaurs consists mainly of their fused, complexly sculptured dentaries, but little is known about the growth and development of this diagnostic structure. Previous work has suggested that the ridges and grooves on the occlusal surface are either the vestiges of teeth and their alveoli or were adaptations to increase shearing action during mastication. In addition, the distinctiveness of the dentaries has led to their use for species‐level taxonomy, without a complete understanding of their variation through ontogeny. Here, we describe additional caenagnathid mandibles from the Dinosaur Park Formation of Alberta, Canada, and perform histological analyses to assess relative ontogenetic stage and the nature of the occlusal elaborations. The results show that the mandibular symphysis is synostosed early in ontogeny and does not accurately reflect ontogenetic stage in caenagnathids. In contrast, the presence of cyclical growth marks in a large specimen shows that mandibles can be used for relative histological maturity estimation. Histological features of the ridges of bone surrounding the lingual groove indicate that they are not the vestiges of tooth‐bearing tissues and that caenagnathids did not lose their teeth through ontogeny as suggested in previous work. Instead, increased secondary remodeling in these structures is consistent with their use for food processing. Unexpectedly advanced maturity in a small specimen suggests that at least three caenagnathid species of varying body sizes coexisted in the Dinosaur Park Formation. These results stress the necessity of histological analysis when assessing maturity or ontogenetic trends in fossil material. Anat Rec, 303:918–934, 2020. © 2019 Wiley Periodicals, Inc.