bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring levels and correlates of health literacy in Arabic and Vietnamese immigrant patients with cancer and their English-speaking counterparts in Australia: a cross-sectional study protocol
Authors: Gerges Martha , Smith Allan Ben , Durcinoska Ivana , Yan Henry , Girgis Afaf 
Published: August 2018

IntroductionFor immigrants diagnosed with cancer, the stress of a cancer diagnosis and treatment can be amplified by unfamiliarity with the health system, lack of culturally and linguistically appropriate information, and inability to communicate efficiently and accurately with the treating team. Lower levels of health literacy may be one factor underlying poorer outcomes among immigrant patients with cancer, but there have been few studies exploring this issue to date. This study aims to investigate the levels and correlates of health literacy in two immigrant populations affected by cancer and their English-speaking counterparts.Methods and analysisLevels and correlates of health and eHealth literacy will be evaluated using a cross-sectional self-report questionnaire. Eligible, English, Arabic and Vietnamese patients with cancer and survivors (n=50 of each language group) will be invited to complete a questionnaire in their preferred language containing the Health Literacy Questionnaire, the eHealth Literacy Scale and study-specific questions assessing potential correlates of poor health literacy, including gender, age, education level, acculturation into Australian society and number of chronic illnesses.Multivariable logistic regression will be used to identify potential approaches to support effective communication with healthcare providers and preferred methods for assessing patient-reported outcomes (PROs) to support culturally appropriate cancer care.The outcomes of this study will be used to better meet the needs of immigrant populations, including the tailoring of interventions appropriate to different health literacy levels. Outcomes will also inform strategies for PRO assessment to inform unmet needs and to address Australian healthcare system challenges to meet the needs of immigrant populations.Ethics and disseminationThe study was reviewed and approved by the Human Research Ethics Committee of South Western Sydney Local Health District (approval number: HREC/16/LPOOL/650). Results from the study will aim to be published at international conferences and in peer-reviewed journals.
Prevalence of atrial fibrillation and cardiovascular risk factors in a 63–65 years old general population cohort: the Akershus Cardiac Examination (ACE) 1950 Study
Authors: Berge Trygve , Lyngbakken Magnus Nakrem , Ihle-Hansen Håkon , Brynildsen Jon , Pervez Mohammad Osman , Aagaard Erika Nerdrum , Vigen Thea , Kvisvik Brede , Christophersen Ingrid Elisabeth , Steine Kjetil , Omland Torbjørn , Smith Pål , Røsjø Helge , Tveit Arnljot 
Published: August 2018

ObjectivesTo investigate the sex-specific prevalence of atrial fibrillation (AF), including subclinical AF found by screening in a general population aged 63–65 years. The prevalence of cardiovascular risk factors and their association with AF will also be investigated.DesignCross-sectional analysis of an observational, prospective, longitudinal, population-based cohort study.SettingGeneral population in Akershus county, Norway.ParticipantsWomen and men born in 1950. We included 3706 of 5827 eligible individuals (63.6%); 48.8% were women.MethodsAll participants underwent extensive cardiovascular examinations, including 12-lead ECG. History of AF and other cardiovascular diseases were self-reported. Subsequent validation of all reported or detected AF diagnoses was performed.ResultsMean age was 63.9±0.7 years. Prevalence of ECG-verified AF was 4.5% (women 2.4%, men 6.4%; p<0.001), including screen-detected AF in 0.3% (women 0.1%, men 0.6%; p<0.01). Hypertension was found in 62.0% (women 57.8%, men 66.0%; p<0.001). Overweight or obesity was found in 67.6% (women 59.8%, men 74.9%; p<0.001). By multivariate logistic regression, risk factors associated with AF were height (OR 1.67 per 10 cm; 95% CI 1.26 to 2.22; p<0.001), weight (OR 1.15 per 10 kg; 95% CI 1.01 to 1.30; p=0.03), hypertension (OR 2.49; 95% CI 1.61 to 3.86; p<0.001), heart failure (OR 3.51; 95% CI 1.71 to 7.24; p=0.001), reduced estimated glomerular filtration rate (OR 2.56; 95% CI 1.42 to 4.60; p<0.01) and at least one first-degree relative with AF (OR 2.32; 95% CI 1.63 to 3.31; p<0.001), whereas male sex was not significantly associated (OR 1.00; 95% CI 0.59 to 1.68; p=0.99).ConclusionIn this cohort from the general population aged 63–65 years, we found a higher prevalence of known AF than previously reported below the age of 65 years. The additional yield of single time point screening for AF was low. Body size and comorbidity may explain most of the sex difference in AF prevalence at this age.Trial registration numberNCT01555411; Results.
Cohort Profile: the Predictors of Breast Cancer Recurrence (ProBe CaRE) Premenopausal Breast Cancer Cohort Study in Denmark
Authors: Collin Lindsay J , Cronin-Fenton Deirdre P , Ahern Thomas P , Christiansen Peer M , Damkier Per , Ejlertsen Bent , Hamilton-Dutoit Stephen , Kjærsgaard Anders , Silliman Rebecca A , Sørensen Henrik Toft , Lash Timothy L 
Published: August 2018

PurposeThe Predictors of Breast Cancer Recurrence (ProBe CaRe) study was established to evaluate modification of tamoxifen (TAM) effectiveness in premenopausal women through reduced activity of TAM-metabolising enzymes. It comprehensively evaluates the effects of pharmacogenetic variants, use of concomitant medications and biomarkers involved in oestrogen metabolism on breast cancer recurrence risk.ParticipantsThe ProBe CaRe study was established using resources from the Danish Breast Cancer Group (DBCG), including 5959 premenopausal women diagnosed with stage I–III primary breast cancer between 2002 and 2010 in Denmark. Eligible participants were divided into two groups based on oestrogen receptor alpha (ERα) expression and receipt of TAM therapy, 4600 are classified as ERα+/TAM+ and 1359 are classified as ERα−/TAM−. The ProBe CaRe study is a population-based cohort study nested in a nearly complete source population, clinical, tumour and demographic data were abstracted from DBCG registry data. Linkage to Danish registries allows for abstraction of information regarding comorbid conditions, comedication use and mortality. Formalin-fixed paraffin-embedded tissue samples have been prepared for DNA extraction and immunohistochemical assay.Findings to dateTo mitigate incorrect classification of patients into specific categories, we conducted a validation substudy. We compared data acquired from registry and from medical record review to calculate positive predictive values (PPVs) and negative predictive values. We observed PPVs near 100% for tumour size, lymph node involvement, receptor status, surgery type, receipt of radiotherapy, receipt of chemotherapy and TAM treatment. We found that the PPVs were 96% (95% CI 83% to 100%) for change in endocrine therapy and 61% (95% CI 42% to 77%) for menopausal transition.Future plansThe ProBeCaRe cohort study is well positioned to comprehensively examine pharmacogenetic variants. We will use a Bayesian pathway analysis to evaluate the complete TAM metabolic path to allow for gene–gene interactions, incorporating information of other important patient characteristics.
Estimating the current and future cancer burden in Canada: methodological framework of the Canadian population attributable risk of cancer (ComPARe) study
Authors: Brenner Darren R , Poirier Abbey E , Walter Stephen D , King Will D , Franco Eduardo L , Demers Paul A , Villeneuve Paul J , Ruan Yibing , Khandwala Farah , Grevers Xin , Nuttall Robert , Smith Leah , De Prithwish , Volesky Karena , O’Sullivan Dylan , Hystad Perry , Friedenreich Christine M 
Published: August 2018

IntroductionThe Canadian Population Attributable Risk of Cancer project aims to quantify the number and proportion of cancer cases incident in Canada, now and projected to 2042, that could be prevented through changes in the prevalence of modifiable exposures associated with cancer. The broad risk factor categories of interest include tobacco, diet, energy imbalance, infectious diseases, hormonal therapies and environmental factors such as air pollution and residential radon.Methods and analysisUsing a national network, we will use population-attributable risks (PAR) and potential impact fractions (PIF) to model both attributable (current) and avoidable (future) cancers. The latency periods and the temporal relationships between exposures and cancer diagnoses will be accounted for in the analyses. For PAR estimates, historical exposure prevalence data and the most recent provincial and national cancer incidence data will be used. For PIF estimates, we will model alternative or ‘counterfactual’ distributions of cancer risk factor exposures to assess how cancer incidence could be reduced under different scenarios of population exposure, projecting incidence to 2042.DisseminationThe framework provided can be readily extended and applied to other populations or jurisdictions outside of Canada. An embedded knowledge translation and exchange component of this study with our Canadian Cancer Society partners will ensure that these findings are translated to cancer programmes and policies aimed at population-based cancer risk reduction strategies.
Protocol to develop sustainable day care for children aged 1–4 years in disadvantaged urban communities in Dhaka, Bangladesh
Authors: Das Mahua , Elsey Helen , Shawon Riffat Ara , Hicks Joseph , Ferdoush J , Huque Rumana , Fieroze Fariza , Nasreen Shammi , Wallace Hilary , Mashreky Saidur R 
Published: August 2018

IntroductionLack of safe, stimulating and health-promoting environments for children under-5 hinders their physical, social and cognitive development, known as early childhood development (ECD). Improving ECD impacts on children, and can improve educational attainment for girls, who often care for younger siblings, and employment prospects for mothers. Developing and evaluating the impacts of ECD programmes within childcare needs to assess a range of social, health, educational and economic impacts, including women’s empowerment.Children living in slums are at high risk of poor early development and holistic, sustainable interventions are needed to address ECD in these contexts. This study will be undertaken in Dhaka, Bangladesh, a city where over 8.5 million inhabitants live in slums. In collaboration with government, non-governmental organisations and communities, we are developing and testing a sustainable day-care model for low-income communities in Dhaka.Methodology and analysisA sequential mixed methods approach is being used in the study, with qualitative work exploring quantitative findings. Two hundred households with children under-5 will be surveyed to determine day-care needs and to assess ECD (parent-reported and direct assessment). The feasibility of four ECD measuring tools Caregiver-Reported Early Development Index, Measuring Early Learning Quality and Outcomes, The Early Human Capability Index and International Development and Early Learning Assessment will be assessed quantitatively and qualitatively. Qualitative methods will help understand demand and perceptions of day care while mothers work. Participatory action research will be used to develop a locally appropriate and potentially sustainable model of day care for under-5 children. A ward in the south of Dhaka has been selected for the study as this typifies communities with slum and non-slum households living next to each other, allowing us to explore potential for better-off household to subsidise day care for poorer households.Ethics and disseminationFindings will be published and inform decision makers at the national, regional and the local actors in order to embed the study into the policy and practice on childcare and ECD. Ethical approvals for this study were obtained from the School of Medicine Research Ethics Committee at the Faculty of Medicine and Health at the University of Leeds (ref: MREC16-106) and the Bangladesh Medical Research Council (ref: BMRCAIREC/20 I 6-20 I 9 I 250).
Community study to uncover the full spectrum of rheumatic heart disease in Uganda
Authors: Scheel Amy , Ssinabulya Isaac , Aliku Twalib , Bradley-Hewitt Tyler , Clauss Alexa , Clauss Sarah , Crawford Lexi , DeWyer Alyssa , Donofrio Mary T , Jacobs Marni , Klein Jennifer , Moore Teresa E , Okello Emmy , Scheel Janet , Shaw Rebekah , Sable Craig , Lwabi Peter , Watkins David A , Beaton Andrea 
Published: August 2018

ObjectiveEstimates of the prevalence of rheumatic heart disease (RHD) in many endemic countries are limited to samples of children attending schools, which generate an incomplete picture of disease burden in communities. The present study conducted household-based RHD screening in a representative community in Gulu district, Uganda.MethodsMembers of households identified through a two-stage cluster-sampling approach between the ages of 5 years and 50 years were invited to undergo limited cardiac testing with a handheld echocardiogram to assess for the presence of RHD. Suspicious cases underwent confirmatory echocardiogram with a fully functional machine.ResultsOf the 2453 community members screened, 2.45% (95% CI 1.87% to 3.14%) showed echocardiographic evidence of RHD with 1.26% (95% CI 0.860% to 1.79%) having definite RHD. The overall prevalence of RHD among participants <20 years was 2.52% (95% CI 1.78% to 3.45%), with a borderline prevalence of 1.97% (95% CI 1.33% to 2.82%) and a definite prevalence of 0.544% (95% CI 0.235% to 1.07%). Prevalence rates among youth increased with age and peaked in the age group of 16–20 years. The overall adult prevalence (>20 years) of RHD was 2.34% (95% CI 1.49% to 3.49%). The majority of definite cases were mild (81%) and marked by mitral regurgitation and associated morphological valve changes (71%).ConclusionOur data reveal a high prevalence of undiagnosed RHD within an endemic community and fill a critical gap in RHD epidemiology in African adults.
Influence of arginine on enzymes related to arginine metabolism in bovine mammary epithelial cells in vitro
Authors: Hu Liangyu , Xu Bolin , Wang Yifan , Wang Mengzhi , Wang Hongrong 
Published: August 2018

Bovine mammary epithelial cells were used to evaluate the effects of different levels of Arginine (Arg) on enzymes related to Arg metabolism. A series of seven Arg concentrations in the medium as treatments were T0 (0.00 mg L−1) as control group, and T0.25 (69.50 mg L−1), T0.5 (139.00 mg L−1), T1 (278.00 mg L−1), T2 (556.00 mg L−1), T4 (1112.00 mg L−1), and T8 (2224.00 mg L−1) as experiment groups, respectively. The quantitative polymerase chain reaction and enzyme-linked immunosorbent assay analysis showed that the nitric oxide concentration, the expressions of endothelial nitric oxide synthase in mRNA, and enzyme level were all increased in response to enhanced Arg doses such that the T8 was the greatest group (P < 0.05). Four-fold Arg concentration improved gene expression and synthesis of arginase which then deceased when excessive Arg was supplied (P < 0.05). The expressions of ornithine aminotransferase mRNA and enzyme in T1 and T2 groups were significantly greater than that in the other groups (P < 0.05). Two-fold Arg was the optimum level for ornithine decarboxylase gene expression and enzyme synthesis among all seven treatments (P < 0.05). These somewhat various effects of Arg concentrations on four kinds of enzymes in different Arg metabolic pathways suggest that Arg might participate in regulating bovine mammary physiological function with an optimum concentration by influencing the enzymes in related metabolic pathways.
Bi-amalgamated constructions
Authors: Campanini Federico , Finocchiaro Carmelo Antonio 
Published: August 2018

Let [Formula: see text] be ring homomorphisms and let [Formula: see text] (respectively, [Formula: see text]) be an ideal of [Formula: see text] (respectively, [Formula: see text]) satisfying [Formula: see text]. Recently, Kabbaj, Louartiti and Tamekkante defined and studied the following subring: [Formula: see text] of [Formula: see text], called the bi-amalgamation of [Formula: see text] with [Formula: see text] along [Formula: see text], with respect to [Formula: see text]. This ring construction is a natural generalization of the amalgamated algebras, introduced and studied by D’Anna, Finocchiaro and Fontana. The aim of this paper is to continue the investigation started by Kabbaj, Louartiti and Tamekkante by providing a deeper insight on the ideal-theoretic structure of bi-amalgamations.
Isaiah 10:34 and the “Ambiguous Oracle” in Josephus, Bellum 6.312–313 (Part One)
Authors: Aus Roger David 
Published: August 2018

Abstract
One of the most disputed passages in Josephus is found only late in his account of the Jewish war against Rome, 66–70 CE. After relating numerous phenomena he considered portents of the destruction of Jerusalem with the Temple, he notes two oracles. The first, in Bell. 6.311, has never been traced back to a specific scriptural passage or Judaic tradition. The second, in 6.312–13, is the object of this study, in which I argue that Isa. 10:34 is the biblical verse behind the “ambiguous oracle.”
“Some Animals Die from Eating this Herb:” The Controversy between R. Yosef Caro and R. Moses di Trani Concerning the Common Giant Fennel
Authors: Shemesh Abraham Ofir 
Published: August 2018

Abstract
In 1552, a virulent halakhic polemic opposed R. Joseph Caro and R. Moses Terani. The case happened in a slaughterhouse in Safed where shehita of cattle had taken place. It was found that the animals’ stomachs were in a bad condition. It was argued that the cause was a plant the animals had ingested—Kelekh. The two rabbis published different halakhic decisions concerning the kashrut of these animals. Caro declared that the meat was not permitted, while Terani allowed consumption of the meat. Kelekh is common giant fennel. The two rabbis addressed three questions: Does the plant render animals ritually unfit for eating? What is the meaning of the pathological symptoms found in the stomach of the livestock? Which parts of the plant are the source of the problem? The dispute between the rabbis had various consequences for the Jewish community: economic, health-related, and social.
Which Attribute of Ceiling Color Influences Perceived Room Height?
Authors: von Castell Christoph , Hecht Heiko , Oberfeld Daniel 
Published: August 2018

Objective: We investigate effects of the hue, saturation, and luminance of ceiling color on the perceived height of interior spaces. Background: Previous studies have reported that the perceived height of an interior space is influenced by the luminance of the ceiling, but not by the luminance contrast between ceiling and walls: brighter ceilings appeared higher than darker ceilings, irrespective of wall and floor luminance. However, these studies used solely achromatic colors. We report an experiment in which we extend these findings to effects of chromatic ceiling colors. Methods: We presented stereoscopic room simulations on a head-mounted display (Oculus Rift DK2) and varied hue (red, green, blue), saturation (low, high), and luminance (bright, dark) of the ceiling independently of each other. Results: We found the previously reported ceiling luminance effect to apply also to chromatic colors: subjects judged brighter ceilings to be higher than darker ceilings. The remaining color dimensions merely had a very small (hue) or virtually no effect (saturation) on perceived height. Conclusion: In order to maximize the perceived height of an interior space, we suggest painting the ceiling in the brightest possible color. The hue and saturation of the paint are only of minor importance. Application: The present study improves the empirical basis for interior design guidelines regarding effects of surface color on the perceived layout of interior spaces.
Trial and error, together: divergent thinking and collective learning in the implementation of integrated care networks
Authors: Evans Jenna M. , Grudniewicz Agnes , Tsasis Peter 
Published: August 2018

Hybrid networks that link disparate professionals and organizations are a common approach to deliver integrated care to patients. Recent literature argues that successful implementation of these networks demands a socio-cognitive perspective in which stakeholder mental frames and thought processes are prioritized, investigated, and compared. The aims of this article are to identify where mindsets diverge among clinical and managerial stakeholders involved in the implementation of integrated care networks known as ‘Health Links’ (HLs) in Ontario, Canada, and to describe strategies to support stakeholders’ capacity to collectively learn and develop more convergent views. Drawing from shared mental model theory and practice-based learning theory, a secondary analysis was conducted of interview data with 55 healthcare professionals and managers involved in the implementation of HLs. We identified examples of divergences in stakeholders’ conceptualization of the HL design and approach (‘strategy mental model’) and their perceptions of each other and how they work together (‘relationship mental model’). We also identified four strategies that facilitate learning and possibly mental model convergence. The results of the study may help guide stakeholder dialogue towards collective learning and coordinated action for integrated care delivery. Points for practitioners The findings suggest that in the implementation of large-scale change involving multiple stakeholder groups, there are predictable areas where divergent views are likely to occur and may have a negative impact on coordinated action. An awareness of these potential divergences can guide practitioners to examine them explicitly and regularly, and to proactively develop strategies to support practice-based learning and the development of a convergent perspective.
Incidence, Distribution, and Cost of Lawn-Mower Injuries in the United States, 2006-2013
Authors: Hottinger Daniel G. , Nasr Isam , Canner Joseph K. , Kattail Deepa , Koka Rahul , Schwengel Deborah 
Published: August 2018

Objectives: Characterization of the epidemiology and cost of lawn-mower injuries is potentially useful to inform injury prevention and health policy efforts. We examined the incidence, distribution, types and severity, and emergency department (ED) and hospitalization charges of lawn-mower injuries among all age groups across the United States. Methods: This retrospective, cross-sectional study used nationally representative, population-based (all-payer) data from the US Nationwide Emergency Department Sample for lawn-mower–related ED visits and hospitalizations from January 1, 2006, through December 31, 2013. Lawn-mower injuries were identified by using International Classification of Diseases, Ninth Revision, Clinical Modification code E920 (accidents caused by a powered lawn mower). We analyzed data on demographic characteristics, age, geographic distribution, type of injury, injury severity, and hospital charges. Results: We calculated a weighted estimate of 51 151 lawn-mower injuries during the 8-year study period. The most common types of injuries were lacerations (n = 23 907, 46.7%), fractures (n = 11 433, 22.4%), and amputations (n = 11 013, 21.5%). The most common injury locations were wrist or hand (n = 33 477, 65.4%) and foot or toe (n = 10 122, 19.8%). Mean ED charges were $2482 per patient, and mean inpatient charges were $36 987 per patient. The most common procedures performed were wound irrigation or debridement (n = 1436, 29.9%) and amputation (n = 1230, 25.6%). Conclusions: Lawn-mower injuries occurred at a constant rate during the study period. Changes to nationwide industry safety standards are needed to reduce the frequency and severity of these preventable injuries.