bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faculty development for junior health professionals
Authors: Burgess Annette , van Diggele Christie , Mellis Craig 
Published: May 2018

SummaryBackgroundThe need for faculty development programmes designed to help junior health professionals fulfill their multiple roles, across various institutions, is widely acknowledged. Such programmes are usually logistically difficult for hospital clinicians to access, however, and are discipline based. In 2017, we collaborated with four health care faculties to develop a blended learning, interprofessional faculty development programme that was up to date, relevant, and accessible to clinicians working in the hospital and university settings. The purpose of our study was to explore participants’ perceptions of the structure, processes and outcomes of the programme, using the conceptual framework of communities of practice.MethodsThe Clinical Teacher Training (CTT) programme included eight modules delivered using a blended learning format. Participants were provided with education literature, online activities and videos, plus in‐class opportunities for active participation in small interprofessional learning groups and large group sessions. Quantitative data were collected from participants by questionnaire, and then analysed using descriptive statistics. Qualitative data were collected by focus group. Framework analysis was used to code the data set using ‘communities of practice’ as a conceptual framework.
[Faculty development] programmes are usually logistically difficult for hospital clinicians to access and are discipline basedFindingsParticipants felt able to achieve most of the CTT programme learning outcomes through active participation, formative assessment and feedback. Participants felt that their learning was enriched through the blended learning platform, and through delivery within an interprofessional context; however, participants suggested it would be beneficial if more content was delivered through face‐to‐face sessions, particularly regarding ‘Journal Club’ and ‘Mentorship’ modules. Although participants felt well prepared to teach students, they felt less well prepared for assessment activities.
Creating a Collaborative Care Curriculum Framework
Authors: Maddock Bronwyn , Kumar Arunaz , Kent Fiona 
Published: May 2018

SummaryBackgroundA faculty‐wide approach to curriculum design is required to ensure students within all health professional courses are provided with relevant interprofessional education opportunities across their course of study. Within the Faculty of Medicine, Nursing and Health Sciences at Monash University, Australia, a Collaborative Care Curriculum Framework was developed to detail the learning outcomes for collaborative care for pre‐registration students.MethodsA six‐stage process was undertaken. A working group was established, and existing literature, interprofessional frameworks and accreditation documents were analysed, and themes extracted. Consensus was obtained across the multiple professions (12 in our context) regarding the main themes and student learning outcomes. Multimedia was engaged to facilitate the communication of the framework across the faculty.DiscussionKeys to the successful development of the framework included reference to profession‐specific accreditation requirements, incorporating patient and student perspectives, and working with multimedia to produce clear professional documents. The outcome of the six‐stage structured process was the establishment of an agreed framework for use across professions when planning an interprofessional curriculum. Subsequent benefits of developing the framework include a shared language, vision and priorities for the development of new interprofessional curriculum activities.A Collaborative Care Curriculum Framework was developed to detail the learning outcomes for pre‐registration studentsConclusionEach stage of the framework development is outlined to allow others to replicate the process in their local context. The process undertaken and the challenges encountered are described, in addition to the subsequent benefits for faculty members and students.
Forecasting zoonotic cutaneous leishmaniasis using meteorological factors in eastern Fars province, Iran: a SARIMA analysis
Authors: Tohidinik Hamid Reza , Mohebali Mehdi , Mansournia Mohammad Ali , Niakan Kalhori Sharareh R. , Ali‐Akbarpour Mohsen , Yazdani Kamran 
Published: May 2018

AbstractObjectivesTo predict the occurrence of zoonotic cutaneous leishmaniasis (ZCL) and evaluate the effect of climatic variables on disease incidence in the east of Fars province, Iran using the Seasonal Autoregressive Integrated Moving Average (SARIMA) model.MethodsThe Box‐Jenkins approach was applied to fit the SARIMA model for ZCL incidence from 2004 to 2015. Then the model was used to predict the number of ZCL cases for the year 2016. Finally, we assessed the relation of meteorological variables (rainfall, rainy days, temperature, hours of sunshine and relative humidity) with ZCL incidence.ResultsSARIMA(2,0,0) (2,1,0)12 was the preferred model for predicting ZCL incidence in the east of Fars province (validation Root Mean Square Error, RMSE = 0.27). It showed that ZCL incidence in a given month can be estimated by the number of cases occurring 1 and 2 months, as well as 12 and 24 months earlier. The predictive power of SARIMA models was improved by the inclusion of rainfall at a lag of 2 months (β = −0.02), rainy days at a lag of 2 months (β = −0.09) and relative humidity at a lag of 8 months (β = 0.13) as external regressors (P‐values < 0.05). The latter was the best climatic variable for predicting ZCL cases (validation RMSE = 0.26).ConclusionsTime series models can be useful tools to predict the trend of ZCL in Fars province, Iran; thus, they can be used in the planning of public health programmes. Introducing meteorological variables into the models may improve their precision.
What good is weed diversity?
Authors: Storkey J , Neve P 
Published: May 2018

SummaryShould the declining diversity of weed communities in conventionally managed arable fields be regarded as a problem? The answer to this question has tended to divide researchers into those whose primary focus is on conserving farmland biodiversity and those whose goals are dictated by weed control and maximising yield. Here, we argue that, regardless of how weeds are perceived, there are common ecological principles that should underpin any approach to managing weed communities, and, based on these principles, increasing in‐field weed diversity could be advantageous agronomically as well as environmentally. We hypothesise that a more diverse weed community will be less competitive, less prone to dominance by highly adapted, herbicide‐resistant species and that the diversity of the weed seedbank will be indicative of the overall sustainability of the cropping system. Common to these hypotheses is the idea that the intensification of agriculture has been accompanied by a homogenisation of cropping systems and landscapes, accounting for both declines in weed diversity and the reduced resilience of cropping systems (including the build‐up of herbicide resistance). As such, weed communities represent a useful indicator of the success of rediversifying systems at multiple scales, which will be a central component of making agriculture and weed control more sustainable.
Draft Genome Sequence of the Feruloyl Esterase-Producing Strain Lactobacillus fermentum CRL1446, a Probiotic for Malnutrition
Authors: Abeijón Mukdsi María C. , Saavedra Lucila , Gauffin Cano María P. , Hebert Elvira M. , Medina Roxana B. 
Published: May 2018

ABSTRACT

We report here the draft genome sequence of
Lactobacillus fermentum
CRL1446 (2,148,781 bp, 51.4% G+C content). This strain exhibits feruloyl esterase activity and important technological and probiotic properties. Because of its proven beneficial effects
in vivo
, it represents an interesting candidate for the development of functional foods or pharmabiotics for malnutrition.
Complete Genome Sequence of Escherichia coli J53, an Azide-Resistant Laboratory Strain Used for Conjugation Experiments
Authors: Matsumura Yasufumi , Peirano Gisele , Pitout Johann D. D. 
Published: May 2018

ABSTRACT

We report here the complete genome sequence of
Escherichia coli
J53, which is used as a recipient in conjugation experiments and is a laboratory strain derived from
E. coli
K-12. This genome sequence will help in the development of a comprehensive genetic analysis of conjugative elements.
Complete Genome Sequence of Streptomyces lunaelactis MM109
T
, Isolated from Cave Moonmilk Deposits
Authors: Naômé Aymeric , Maciejewska Marta , Calusinska Magdalena , Martinet Loïc , Anderssen Sinaeda , Adam Delphine , Tenconi Elodie , Deflandre Benoit , Coppieters Wouter , Karim Latifa , Hanikenne Marc , Baurain Denis , Delfosse Philippe , van Wezel Gilles P. , Rigali Sébastien 
Published: May 2018

ABSTRACT

Streptomyces lunaelactis
MM109
T
is a ferroverdin A (anticholesterol) producer isolated from cave moonmilk deposits. The complete genome sequence of MM109
T
was obtained by combining Oxford Nanopore MinION and Illumina HiSeq and MiSeq technologies, revealing an 8.4-Mb linear chromosome and two plasmids, pSLUN1 (127,264 bp, linear) and pSLUN2 (46,827 bp, circular).
A two-dimensional layer-averaged numerical model for turbidity currents
Authors: Yang Shihao , An Yi , Liu Qingquan 
Published: May 2018

Abstract
Turbidity currents occur widely in submarine environments, but field-scale numerical simulations of the flow features have not been applied extensively. Here, we present a two-dimensional layer-averaged numerical model to simulate turbidity currents over an erodible sediment bed, and taking into consideration deposition, entrainment and friction. The numerical model was developed based on the open-source code, Basilisk, ensuring well-balanced and positivity-preserving properties. An adaptive spatial discretization was used, which allows multi-level refinement. The adaptive criterion is based on the dynamic features of the flow and sediment concentrations. The numerical scheme has a relatively high computational efficiency compared with models based on the Cartesian mesh. A hypothetical case based on a true large-scale landform (the Moroccan Turbidite System, offshore NW Africa) was studied. Compared with previous models, the current model accounted for the coupling between flow, sediment transportation and bed evolution. This approach may improve simulation results and also allow the simulation of complex field-scale landforms, while preserving the flow details.
Co-Simulation
Authors: Gomes Cláudio , Thule Casper , Broman David , Larsen Peter Gorm , Vangheluwe Hans 
Published: May 2018

Modeling and simulation techniques are today extensively used both in industry and science. Parts of larger systems are, however, typically modeled and simulated by different techniques, tools, and algorithms. In addition, experts from different disciplines use various modeling and simulation techniques. Both these facts make it difficult to study coupled heterogeneous systems.
Co-simulation is an emerging enabling technique, where global simulation of a coupled system can be achieved by composing the simulations of its parts. Due to its potential and interdisciplinary nature, co-simulation is being studied in different disciplines but with limited sharing of findings.
In this survey, we study and survey the state-of-the-art techniques for co-simulation, with the goal of enhancing future research and highlighting the main challenges.
To study this broad topic, we start by focusing on discrete-event-based co-simulation, followed by continuous-time-based co-simulation. Finally, we explore the interactions between these two paradigms, in hybrid co-simulation.
To survey the current techniques, tools, and research challenges, we systematically classify recently published research literature on co-simulation, and summarize it into a taxonomy. As a result, we identify the need for finding generic approaches for modular, stable, and accurate coupling of simulation units, as well as expressing the adaptations required to ensure that the coupling is correct.
A Survey of Network Traffic Anonymisation Techniques and Implementations
Authors: Dijkhuizen Niels Van , Ham Jeroen Van Der 
Published: May 2018

Many networking research activities are dependent on the availability of network captures. Even outside academic research, there is a need for sharing network captures to cooperate on threat assessments or for debugging. However, most network captures cannot be shared due to privacy concerns.
Anonymisation of network captures has been a subject of research for quite some time, and many different techniques exist. In this article, we present an overview of the currently available techniques and implementations for network capture anonymisation.
There have been many advances in the understanding of anonymisation and cryptographic methods, which have changed the perspective on the effectiveness of many anonymisation techniques. However, these advances, combined with the increase of computational abilities, may have also made it feasible to perform anonymisation in real time. This may make it easier to collect and distribute network captures both for research and for other applications.
<?tight?>This article surveys the literature over the period of 1998–2017 on network traffic anonymisation techniques and implementations. The aim is to provide an overview of the current state of the art and to highlight how advances in related fields have shed new light on anonymisation and pseudonimisation methodologies. The few currently maintained implementations are also reviewed. Last, we identify future research directions to enable easier sharing of network traffic, which in turn can enable new insights in network traffic analysis.
Directed Multicut is W[1]-hard, Even for Four Terminal Pairs
Authors: Pilipczuk Marcin , Wahlström Magnus 
Published: May 2018

We prove that M
ulticut
in directed graphs, parameterized by the size of the cutset, is
W
[1]-hard and hence unlikely to be fixed-parameter tractable even if restricted to instances with only four terminal pairs. This negative result almost completely resolves one of the central open problems in the area of parameterized complexity of graph separation problems, posted originally by Marx and Razgon [SIAM J. Comput. 43(2):355--388 (2014)], leaving only the case of three terminal pairs open. The case of two terminal pairs was shown to be FPT by Chitnis et al. [SIAM J. Comput. 42(4):1674--1696 (2013)].

Our gadget methodology also allows us to prove
W
[1]-hardness of the S
teiner
O
rientation
problem parameterized by the number of terminal pairs, resolving an open problem of Cygan, Kortsarz, and Nutov [SIAM J. Discrete Math. 27(3):1503-1513 (2013)].
Nanobody–Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses
Authors: Woodham Andrew W. , Cheloha Ross W. , Ling Jingjing , Rashidian Mohammad , Kolifrath Stephen C. , Mesyngier Maia , Duarte Joao N. , Bader Justin M. , Skeate Joseph G. , Da Silva Diane M. , Kast W. Martin , Ploegh Hidde L. 
Published: May 2018

Abstract
High-risk human papillomavirus-associated cancers express viral oncoproteins (e.g., E6 and E7) that induce and maintain the malignant phenotype. The viral origin of these proteins makes them attractive targets for development of a therapeutic vaccine. Camelid-derived single-domain antibody fragments (nanobodies or VHHs) that recognize cell surface proteins on antigen-presenting cells (APC) can serve as targeted delivery vehicles for antigens attached to them. Such VHHs were shown to induce CD4+ and CD8+ T-cell responses against model antigens conjugated to them via sortase, but antitumor responses had not yet been investigated. Here, we tested the ability of an anti-CD11b VHH (VHHCD11b) to target APCs and serve as the basis for a therapeutic vaccine to induce CD8+ T-cell responses against HPV+ tumors. Mice immunized with VHHCD11b conjugated to an H-2Db-restricted immunodominant E7 epitope (E749-57) had more E7-specific CD8+ T cells compared with those immunized with E749-57 peptide alone. These CD8+ T cells acted prophylactically and conferred protection against a subsequent challenge with HPV E7-expressing tumor cells. In a therapeutic setting, VHHCD11b-E749-57 vaccination resulted in greater numbers of CD8+ tumor–infiltrating lymphocytes compared with mice receiving E749-57 peptide alone in HPV+ tumor-bearing mice, as measured by in vivo noninvasive VHH-based immune-positron emission tomography (immunoPET), which correlated with tumor regression and survival outcome. Together, these results demonstrate that VHHs can serve as a therapeutic cancer vaccine platform for HPV-induced cancers. Cancer Immunol Res; 6(7); 870–80. ©2018 AACR.
Trends in Noncardiovascular Comorbidities Among Patients Hospitalized for Heart Failure
Authors: Sharma Abhinav , Zhao Xin , Hammill Bradley G. , Hernandez Adrian F. , Fonarow Gregg C. , Felker G. Michael , Yancy Clyde W. , Heidenreich Paul A. , Ezekowitz Justin A. , DeVore Adam D. 
Published: May 2018

Background:
The increase in medical complexity among patients hospitalized with heart failure (HF) may be reflected by an increase in concomitant noncardiovascular comorbidities. Among patients hospitalized with HF, the temporal trends in the prevalence of noncardiovascular comorbidities have not been well described.

Methods and Results:

We used data from 207 984 patients in the Get With The Guidelines–Heart Failure registry (from 2005 to 2014) to evaluate the prevalence and trends of noncardiovascular comorbidities (chronic obstructive pulmonary disorder/asthma, anemia, diabetes mellitus, obesity [body mass index ≥30 kg/m
2
], and renal impairment) among patients hospitalized with HF. Medicare beneficiaries aged ≥65 years were used to assess 30-day mortality. The prevalence of 0, 1, 2, and ≥3 noncardiovascular comorbidities was 18%, 30%, 27%, 25%, respectively. From 2005 to 2014, there was a decline in patients with 0 noncardiovascular comorbidities (22%–16%;
P
<0.0001) and an increase in patients with ≥3 noncardiovascular comorbidities (18%–29%;
P
<0.0001). Among Medicare beneficiaries, there was an increased 30-day adjusted mortality risk among patients with 1 noncardiovascular comorbidity (hazard ratio, 1.16; 95% confidence interval, 1.09–1.24;
P
<0.0001), 2 noncardiovascular comorbidities (hazard ratio, 1.34; 95% confidence interval, 1.25–1.44;
P
<0.0001), and ≥3 noncardiovascular comorbidities (hazard ratio, 1.63; 95% confidence interval, 1.51–1.75;
P
<0.0001). Similar trends were seen for in-hospital mortality.

Conclusions:
Patients admitted in hospital for HF have an increasing number of noncardiovascular comorbidities over time, which are associated with worse outcomes. Strategies addressing the growing burden of noncardiovascular comorbidities may represent an avenue to improve outcomes and should be included in the delivery of in-hospital HF care.
Globalism in Rhythm: Music at the Crossroads of Populism and Multiculturalism
Authors: Freeland Gregory 
Published: May 2018

AbstractThis article deals with music as a generator of political activism, cultural awareness, and popular resistance among people living in politically, religiously, and/or economically unequal situations and globalized unsettled sensitivities. It also examines government responses to music. This article expands the research on the role of music in the political and cultural developments in the twenty-first century. Utilizing lyrics I find music to be a transformative power that communicates political knowledge and social status, which are critical among people seeking identity and place in a globalized world.
Husserl’s Early Theory of Intentionality as a Relational Theory
Authors: Marchesi Andrea 
Published: May 2018

This paper examines Husserl’s theory of intentionality as it is developed inLogical Investigationsand other early writings. In Section 1, the author attempts to capture the core of Husserl’s concept of intentionality. Section 2 is devoted to a detailed analysis of the account of intentional relation developed in the fifthInvestigation. In Section 3, the author tries to flesh out what is meant by the claim in the sixthInvestigationthat the designation ‘object’ is a relative one. In Section 4, the author discusses Husserl’s conception of intentionality in light of the mereology outlined in the thirdInvestigation. In Section 5, the author explains how Husserl criticizes the so-called theory of immanent objects and how he addresses the problem of non-existents. In Section 6, the author argues that a phenomenological theory of intentionality grounded in Husserl’s insights cannot be a non-relational one.
DESCRIPTION OF MUCOR PERNAMBUCOENSIS (MUCORALES, MUCOROMYCOTA), A NEW SPECIES ISOLATED FROM THE BRAZILIAN UPLAND RAINFOREST
Authors: DE LIMA CATARINA L. F. , LIMA DIOGO X. , DE SOUZA CARLOS A. F. , DE OLIVEIRA RAFAEL J. V. , CAVALCANTI INGRID B. , GURGEL LUCIANA M. S. , SANTIAGO ANDRÉ L. C. M. DE A. 
Published: May 2018

The Mucor genus mostly comprises saprobe specimens which are commonly isolated from herbivore dung, fruit and soil. Morphologically, Mucor specimens produce simple or branched sporangiophores without basal rhizoids and non-apophysate sporangia. During a survey of Mucorales in soil from an upland rainforest area in Pernambuco, Brazil, one specimen of Mucor was isolated and characterized based on morphological, physiological and molecular data (ITS1-5.8S-ITS2 and LSU rDNA sequences). The specimen is characterized by producing strongly sympodially branched sporangiophores and sporangiospores which can contain one or more granules at each end. The columellae are frequently globose or obovoid, some ovoid or cylindrical with a truncate base, rarely piriform. It grew better at 25ºC, with no development at 35ºC. Based on the evidence of the analyzed datasets, a new species of Mucor is proposed.
Schizopyga alinae, a genus of pimpline parasitoid wasps (Hymenoptera: Ichneumonidae: Pimplinae) new to the Afrotropical region
Authors: VARGA OLEKSANDR , RESHCHIKOV ALEXEY 
Published: May 2018

Schizopyga Gravenhorst, 1829 is a small genus belonging to the Polysphincta genus-group of the subfamily Pimplinae, with 12 known species worldwide (Yu et al., 2012; Matsumoto, 2016), two of them from the Afrotropical region (Gauld & Dubois, 2006). Schizopyga species are known as parasitoids of spiders creating non-aerial webs (Clubionidae, Gnaphosidae, and Agelenidae) (Matsumoto, 2016).