bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHANGES OF MORPHOLOGY AND IMMUNOREACTIONS IN THE VESSELS OF KIDNEYS, HEART AND AORTA IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors: Jakovtsova I.I. , Topchij I.I. , Daniluk S.V. , Kirienkow A.N. , Dunaievska М.М. 
Published: June 2018

Chronic kidney diseases are etiology of complications in cardiovascular system. Structural and functional changes ofendothelium on a background ofimmunoreactions lies in basis ofthese disorders and complications.
The aim of research was to study of morphologicalfeatures of kidneys and immune reactions in the vessels of kidneys, heart, aorta inpatients with CDK.
Materials and methods. An autopsy material of the 20 dead’s age from 45 to 55 was investigated . The deceased had signs ofchronic desease of kidneys (CDK). Theprimary monoclonal antibody (PMA) company ofDAKO (Denmark) Rady - to - Use were used to reveal of features of cellular immunoreactions in the zones of inflammatoryprocess. We used microscope Primo Star (Carl Zeiss) with theprogram AxioCam (ERc 5s).
Results and discussion. Changes of kidneys vessels, coronary arteries and aorta were characterized of transformation similar with immune inflammation. Condition of endothelium was characterized disorder of endothelization
and manifest irregularity, lumpiness with outcrop of wide intercellular connections. All this proses bring to activation of apoptosis.
Conclusion. Disturbance of vessel morphology and activity of immunoinflammatory reaction can be one of main cause ofdeveloping cardio-vascular complication.
ROLE OF HYPOXIA–INDUCED APOPTOSIS IN CHRONIC GLOMERULONEPHRITIS PROGRESSION IN CHILDREN
Authors: Maidannyk V.G. , Burlaka E.A. , Bagdasarova I.V. , Fomina S.P. , Nepomnyaschiy V.M. 
Published: June 2018

Aim of the study: to study the indicators of cellular hypoxia and apoptosis in pediatric patients with nephritic type of chronic glomerulonephritis.
Material and methods: 52patients with active stage of nephrotic type ofChronic glomerulonephritis were inspected. All patients were divided into groups of Chronic Kidney Disease (CKD) by the level of glomerular filtration rate (GFR). Detection of the hypoxia–induced factor (HIF) and antiapoptotic factor Bcl–xL in serum performed using Western Blotting assay and immunohistochemically on material of kidney biopsies. Imaging was done using confocal laser microscopy.
Results: it has been found that the disease course is accompanied by increased levels of hypoxia–induced factor HIF–1a and decreased expression of antiapoptotic factor Bcl–xL (in plasma and on biopsies). Detected changes significantly depended on the degree of proteinuria and declining of glomerular filtration rate. Dependence between the levels of hypoxia–induced damages and level of kidney function impairment was documented. In children with Chronic Kidney Disease (SKDIst.) HIF–1a was at level 128.6±2.3% (P<0.01, compared to Control group), in children with CKD II–III st. – 141.3±1.9% (P<0.01, compared to Control group and CKD I st.). Level of antiapoptotic defense in children with nephrotic type of Chronic glomerulonephritis was related to the level of kidney function impairment as well. In group of patient with CKDIst. Bcl–xL expression was down–regulated to 75.1±2.2%, in group with CKDII–IIIst. — to 60.1+1.8% (P<0.01 and P<0.001, compared to Control group, respectively). The level of evaluated changes has a dependence on levels ofproteinuria and kidney function impairment.
Conclusion. Studied parameters might be used as predictors of unfavorable disease course.
ACTIVITY OF CHRONIC INFLAMMATION AND ENDOTHELIAL DAMAGE IN PATIENTS WITH CARDIAC VALVE CALCIFICATION IN DIALYSIS–DEPENDENT CHRONIC KIDNEY DISEASE
Authors: Susla O. B. 
Published: June 2018

The purpose of the research was to identify the role of chronic inflammation in mechanisms of cardiac valve calcification (CVC) in patients undergoing chronic hemodialysis (HD) by determining the relation of inflammatory markers with valve calcification and the correlation of the latter with endothelial damage indices.
Methods. The research included 94patients undergoing chronic HD (males, 52, age, (46,4±11,2) years, duration of HD, (28,9±32,4) months). Patients with chronic glomerulonephritis (47,9 %) dominated. All subjects underwent echo– cardiographic examination for detection of CVC. The intensity of the inflammatory process was estimated by the serum content of fibrinogen (FG), amount of circulatory immune complexes (CICs), concentration of C–reactive protein (CRP) and middle molecules (MM). The nitric oxide (NO) production was studied on the plasma content of nitrite–anions (NO2–) by spectrophotometric method, the amount of circulating endothelial cells (CECs) in platelet rich plasma under the method (Hladovec J. et al., 1978), modified by (Susla A.B., Mysula I.R., 2011).
Results. The CRP, FG, CICs indices in patients with CVC exceeded in those without the calcification by 44,2 (р=0,009), 18,4 (р<0,001) and 17,2 % (р=0,002) accordingly. The dynamic of the MM with wave length of 254 nm (MM/254) and 280 nm (MM/280) had identical direction. For the first time a group of patients with CVC (n=42) had been identified with correlations between CECs and CRP indices (Rs=0,42, р=0,006), FG (Rs=0,31, р=0,043), CICs (Rs=0,55, р<0,001), MM/254 (Rs=0,36, р=0,018), MM/280 (Rs=0,42, р=0,005) as well as between the values of NO2– and CRP (Rs=–0,55, р<0,001), FG (Rs=–0,41, р=0,007), CICs (Rs=–0,41, р=0,008), MM/254 (Rs=–0,38, р=0,014), MM/280 (Rs=–0,34, р=0,029).
Conclusions. The valve calcification in HD patients combines with the activation of chronic inflammation, which manifests itself in accumulation of CRP, FG, CICs and MM, and the inflammation markers tightly correlate with endothelial damage and lack of NO
EFFICACY AND SAFETY OF IRON (III)–HYDROXIDE SUCROSE COMPLEX IN CORRECTION OF ANEMIA STAGE 5D CHRONIC KIDNEYDISEASE HEMODIALYSIS PATIENTS NOT TREATED BY ERYTHROPOIESIS–STIMULATING AGENTS (PROSPECTIVEANALYSIS)
Authors: Dudar І. О. , Gonchar I. I. , Shifris І. М. , Krasjuk Е. К. , Savchuk V. М. , Loboda О. М. , Pruskiy F. О. , Krot V. F. , Nechiporuk Т. М. , Alekseeva N. G. 
Published: June 2018

The aim of study was to evaluat the efficacy and safety ofSUFER® (iron (III) sucrose complex) in correction of anemia stage 5D chronic kidney disease hemodialysis patients.
Methods. This study included thirty patients undergoing regular hemodialysis (mean age 48,81±3,24 years, mean duration of dialysis 30,43±9,25 months) with renal anemia and iron deficiency. All patients were treated with SUFER® intravenously 200 mg three times a week. Correction dose was determined according to the manufacturer’s recommendations.
Results. Mean level offerritin was significantly increased from 125,15 ± 21,46 ng / ml to 375,56 ± 64,12 ng / ml (p <0,001), transferrin saturation – from 17,48 ± 2,71% to 38,21 ± 4,90 ng / ml (p <0,001). 23 (76.67%) patients achieved target levels offerritin and transferrin, 12 (40% ) adverse events.
Conclusions. SUFER® is effective and safety drug in dialysis patients.
SERUM NEUTROPHIL GELATINASE - ASSOCIATED LIPOCALIN (NGAL) AS A MARKER OF TUBULOINTERSTITIAL DAMAGE IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS
Authors: Dolinnaya M.A. 
Published: June 2018

Determining of serum creatinine level, glomerular filtration rate and albuminuria gives us no information about tubulointerstitial kidney damage. So it is especially important to search for non - invasive diagnostic methods that allow to diagnose early stages of tubulointerstitial kidney damage and start adequate treatment. This circumstance attempts to use neutrophil gelatinase - associated lipocalin (NGAL) to assess tubulointerstitial kidney damage in patients with chronic glomerulonephritis (CGN).
The aim: to analyze the morphological picture of the kidneys in patients with CGN with arterial hypertension (AH) and without, to investigate the relationship between serum NGAL and histological indexes of tubulointerstitial kidney damage in CGN patients with saved renal function.
Materials and methods. We examined 81 patients with CGN. Patients were divided into two clinical groups: CGN patients with AH, CGN without AH. We analyzed indicators of tubulointerstitial kidney damage according to vivo morphological study, level of serum NGAL.
Conclusion: there is a correlation of varying strength between serum NGAL and indexes of tubulointerstitial kidney damage in CGN patients, strong direct relationship is found between serum NGAL and IF. Diagnostics of IF by determing ofserum NGAL is a highly sensitive and specific method with the efficiency of95.3%. Increase ofserum NGAL above 5ng/ ml indicates a high probability of the IF in CGN patients.Results. Patients with AH have more pronounced histological damage of tubulointerstitial tissue than CGNpatients without AH. Serum NGAL levels are higher in CGN patients with AH and without than in the control group. We find a correlation between serum NGAL and indicators of tubulointer - stitial kidney damage. Analysis of the diagnostic operating characteristics of interstitial fibrosis (IF) by determining of serum NGAL shows that this method is highly sensitive and specific, with an efficiency of95,3%. Constructing ofa non - linear model revealed that increase of serum NGAL level above 5 ng/ml indicates a high probability of the IF in CGN patients.
SYSTEMIC EFFECTS OF LOCAL PRODUCTIONOFPRO- AND ANTI-FIBROGENIC MEDIATORS IN PERITONEAL DIALYSIS PATIENTS
Authors: Stepanova N. , Burdeyna O. , Driyanska V. , Savchenko V. , Kolesnyk M. 
Published: June 2018

Peritonealfibrosis (PF) is a common morphological change in peritoneal dialysis (PD) patients. With the progression of PF, peritoneal membrane function is impaired, which leads to ultrafiltration failure. Results of studies in recent years show the crucial role of high production monocytic chemoattractant protein -1 (MCP-1) of peritoneal fibrosis in PD-patients. The aim was to determine intraperitoneally production ofIL-10 and MCP-1 and its relationship with clinical and laboratory parameters of adequacy of dialysis.
Patients and methods. A prospective observational study involved 18patients with CKD stage Vwith non-diabetic nephropathy, were treated with continuous ambulatory peritoneal dialysis (PAPD). The limits of the normal range (reference range) were obtained from the survey results of 10 conditionally healthy individuals. ELISA method in serum and peritoneal dialysis effluent (PDE) investigated levels ofIL-10 and MSP-1. PAPD adequacy indicators evaluated by determining the concentration of urea and creatinine in plasma, urine and dialysate, calculated weekly creatinine clearance (CrCl), dialysis (Ш/ Vd), renal (Ш / Vr) and шА weekly urea clearance (Kt/ V). nmstep@ukr.net
Results. In all of the PD-patients compared to healthy donors conventionally, there was a significant increase in concentration of the cytokines. We determined the positive regression relationship between the concentration of MCP-1 and IL-10 in PDE and the level of total weekly (Kt / V) and renal (Kt / Vr).
Conclusions. We determined the regression dependence, which allowed to identify clinical parameters that are most closely (statistically significant) related to intraperitoneal production of MCP-1 and IL-10.
ANADOLU ARISI (Apis mellifera anatoliaca)’NIN BAZI ÖNEMLİ ÖZELLİKLERİ
Authors: Sıralı Recep 
Published: June 2018

Anadolu arısı (Apis mellifera anatoliaca) Türkiye’deki
en yaygın arı ırkıdır. Bu arı ırkı, kuzeydoğu ve güneydoğu bölgeleri hariç
ülkenin orta kısımlarındaki yerli arı popülâsyonunu oluşturmaktadır. Bu arı
ırkı doğu arılarının bir dalı olarak
sınıflandırılmıştır. Son zamanlarda yapılan genetik çalışmalar, bu bal arısı
ırkının Doğu Avrupa arılarının bir dalı olduğunu doğrulamıştır. Renk, verim,
morfolojik, fizyolojik ve davranış özellikleri bakımından büyük varyasyon
gösteren Anadolu arısı, çeşitli bölgelere adapte olmuş birçok ekotipe sahiptir.
Anadolu arı ırkının her ekotipi endemik çevresel koşullara sahip yaşam alanında
farklı özellikler ortaya koymaktadır. Anadolu arı ırkının en yaygın ekotipleri
Muğla arısı ve Orta Anadolu arısıdır. Anadolu arıları kirli sarı renkte ve
küçük vücut yapısına sahiptir. İtalyan, Karniyol ve Kafkas arılarına oranla
oldukça hırçın bir ırktır. Bu arı ırkı bazı çok iyi özelliklere de sahiptir.
Nektar toplama, kışlama yeteneği ve oğul eğilimi yüksek fakat yağmacılık
eğilimi düşüktür. Ayrıca kış döneminde az bal tüketen Anadolu bal arısı ırkı,
uygun koşullarda hızlı gelişir. Besin durumuna bağlı olarak iyi larva besleme
eğilimi Anadolu arısının önemli davranış özelliklerindendir. Bunlara ek olarak
kovan içerisinde ilave petek örme ve propolisi fazla taşıyıp kullanma gibi arzu
edilmeyen özelliklere sahiptir.
ARI ÜRÜNLERİ VE HAYVAN BESLEMEDE KULLANIMI
Authors: SUR ARSLAN Aslıhan , BİRBEN Nurgül , TATLI SEVEN Pınar , SEVEN İsmail 
Published: June 2018

Arıcılık
aktivitelerinden bal, polen, propolis, arı sütü ve arı zehiri gibi ürünler elde
edilmektedir. Bu ürünler, halk arasında birçok hastalığın tedavisinde
kullanılmaktadır. Apiterapi adı verilen arı ürünleri ile tedavi yöntemleri son
zamanlarda gelişme göstermektedir. Antibakteriyel, antiviral, antikanserojen,
antioksidan, antiromatizmal v.b. birçok etkisi araştırılmış bu ürünler hayvan besleme
konusunda da son zamanlarda ilgi görmektedir. Bilindiği gibi antibiyotiklerin
yem katkı maddesi olarak kullanımının yasaklanması sebebi ile antibiyotiğe
alternatif doğal ürünlerin kullanımı yaygınlaşmaktadır. Propolis, polen, arı
sütü ve arı zehiri ile yapılan çalışmalar göstermektedir ki bu ürünler
hayvanların yem tüketimini, canlı ağırlığını ve yemden yararlanma oranını
artırarak performans üzerinde olumlu etkiye sebep olabilmektedir. Arı ürünleri
gelişmeyi artırıcı bu özellikleri ile alternatif ürün olarak kullanılabilecek
doğal ürünlerdir. Bu derlemede başta propolis olmak üzere polen, arı sütü ve
arı zehiri gibi doğal ürünlerin hayvan beslemede etkisinin araştırıldığı
çalışmaların derlenerek kullanımları hakkında bilgi verilmesi amaçlanmıştır.&nbsp;
Faktor yang Berhubungan dengan Kasus Skizofrenia pada Pasien Rawat Inap Rumah Sakit Khusus Jiwa Soeprapto Provinsi Bengkulu
Authors: Hermiati Dilfera , Harahap Resnia Madona 
Published: June 2018

The purpose of this study was to determine the factors associated with the incidence of schizophrenia in patients in the Inpatient Room of Soeprapto Special Base Hospital of Bengkulu Province.The method used is descriptive research design with cross sectional approach. Data were collected using primary and secondary data, primary data obtained from the questionnaires to the 67 families of patients treated in inpatient Special Hospital Mental Soeprapto Bengkulu province, while secondary data is taken from the patient's medical record. The sampling technique is by proportional random sampling technique. The analysis showed the majority of respondents, 39 who suffered from schizophrenia, the majority of respondents, 15 contained genetic factors, the majority of respondents, 24 Which there are psychosocial factors, and some of the respondents are 24 people that there are environmental factors. The results of the bivariate analysis showed no significant relationship between genetic schizophrenia in patients in the inpatient unit Special Hospital Mental Soeprapto Bengkulu province, there is a significant relationship between psychosocial with schizophrenia in patients in the inpatient unit Special Hospital Mental Soeprapto Bengkulu province, and there are A significant relationship between the environment and schizophrenia in patients in the inpatient rooms of Soeprapto Special Base Hospital of Bengkulu Province. Keywords: Genetic, Psychosocial, Environmental, Schizophrenia
Complications associated with microscopic and endoscopic transsphenoidal pituitary surgery: experience of 1153 consecutive cases treated at a single tertiary care pituitary center
Authors: Agam Matthew S. , Wedemeyer Michelle A. , Wrobel Bozena , Weiss Martin H. , Carmichael John D. , Zada Gabriel 
Published: June 2018

OBJECTIVEPituitary adenomas (PAs) are benign neoplasms that are frequently encountered during workup for endocrinopathy, headache, or visual loss. Transsphenoidal surgery remains the first-line approach for PA resection. The authors retrospectively assessed complication rates associated with transsphenoidal PA resection from an institutional database.METHODSA retrospective analysis of 1153 consecutive transsphenoidal pituitary adenoma resections performed at the Keck Hospital of USC between November 1992 and March 2017 was conducted. Microscopic transsphenoidal resection was performed in 85.3% of cases, and endoscopic transsphenoidal resection was performed in 14.7%. Analysis of perioperative complications and patient and tumor risk factors was conducted.RESULTSThe overall median hospital stay was 3 days. There was 1 perioperative death (0.1%). Surgical complications included postoperative cerebrospinal fluid leak (2.6%), epistaxis (1.1%), postoperative hematoma (1.1%), meningitis (1.0%), cranial nerve paresis (0.8%), hydrocephalus (0.8%), vision loss (0.6%), stroke (0.3%), abdominal hematoma or infection (0.2%), carotid artery injury (0.1%), and vegetative state (0.2%). Perioperative medical complications included bacteremia/sepsis (0.5%), pneumonia (0.3%), myocardial infarction (0.3%), and deep venous thrombosis/pulmonary embolism (0.1%). Endocrine complications were the most frequent, including transient diabetes insipidus (4.3%), symptomatic hyponatremia (4.2%), new hypopituitarism (any axis) (3.6%), permanent diabetes insipidus (0.3%), and adrenal insufficiency (0.2%). There were no significant differences between microscopic and endoscopic approaches with regard to surgical complications (6.4% vs 8.8%, p = 0.247) or endocrine complications (11.4 vs 11.8%, p = 0.888). Risk factors for surgical complications included prior transsphenoidal surgery (11.4% vs 6.8%, p = 0.025), preoperative vision loss (10.3% vs 6.8%, p = 0.002), and presence of PA invasion on MRI (8.5% vs 4.4%, p = 0.007).CONCLUSIONSIn this single tertiary center study assessing complications associated with transsphenoidal PA resection, the rate of death or major disability was 0.26%. Risk factors for complications included prior surgical treatment and PA invasion. No differences in complication rates between endoscopic and microscopic surgery were observed. When performed at experienced pituitary centers, transsphenoidal surgery for PAs may be performed with a high degree of safety.
Cost-effectiveness of preoperative motor mapping with navigated transcranial magnetic brain stimulation in patients with high-grade glioma
Authors: Butenschön Vicki M. , Ille Sebastian , Sollmann Nico , Meyer Bernhard , Krieg Sandro M. 
Published: June 2018

OBJECTIVENavigated transcranial magnetic stimulation (nTMS) is used to identify the motor cortex prior to surgery. Yet, there has, until now, been no published evidence on the economic impact of nTMS. This study aims to analyze the cost-effectiveness of nTMS, evaluating the incremental costs of nTMS motor mapping per additional quality-adjusted life year (QALY). By doing so, this study also provides a model allowing for future analysis of general cost-effectiveness of new neuro-oncological treatment options.METHODSThe authors used a microsimulation model based on their cohort population sampled for 1000 patients over the time horizon of 2 years. A health care provider perspective was used to assemble direct costs of total treatment. Transition probabilities and health utilities were based on published literature. Effects were stated in QALYs and established for health state subgroups.RESULTSIn all scenarios, preoperative mapping was considered cost-effective with a willingness-to-pay threshold < 3*per capita GDP (gross domestic product). The incremental cost-effectiveness ratio (ICER) of nTMS versus no nTMS was 45,086 Euros/QALY. Sensitivity analyses showed robust results with a high impact of total treatment costs and utility of progression-free survival. Comparing the incremental costs caused by nTMS implementation only, the ICER decreased to 1967 Euros/QALY.CONCLUSIONSMotor mapping prior to surgery provides a cost-effective tool to improve the clinical outcome and overall survival of high-grade glioma patients in a resource-limited setting. Moreover, the model used in this study can be used in the future to analyze new treatment options in neuro-oncology in terms of their general cost-effectiveness.
Outpatient neurosurgery in neuro-oncology
Authors: Marigil Miguel , Bernstein Mark 
Published: June 2018

Technological breakthroughs along with modern application of awake craniotomy and new neuroanesthesia protocols have led to a progressive development in outpatient brain tumor surgery and improved surgical outcomes. As a result, outpatient neurosurgery has become a standard of care at the authors’ center due to its clinical benefits and impact on patient recovery and overall satisfaction. On the other hand, the financial savings derived from its application is also another favorable factor exerting influence on patients, health care systems, and society.Although validated several years ago and with recent data supporting its application, outpatient brain tumor surgery has not gained the traction that it deserves, based on scientific skepticism and perceived potential for medicolegal issues. The goal of this review, based on the available literature and the senior author’s experience in outpatient brain tumor surgery, was to evaluate the most important aspects regarding indications, clinical outcomes, economic burden, and patient perceptions.
Setup presentation and clinical outcome analysis of treating highly language-eloquent gliomas via preoperative navigated transcranial magnetic stimulation and tractography
Authors: Sollmann Nico , Kelm Anna , Ille Sebastian , Schröder Axel , Zimmer Claus , Ringel Florian , Meyer Bernhard , Krieg Sandro M. 
Published: June 2018

OBJECTIVEAwake surgery combined with intraoperative direct electrical stimulation (DES) and intraoperative neuromonitoring (IONM) is considered the gold standard for the resection of highly language-eloquent brain tumors. Different modalities, such as functional magnetic resonance imaging (fMRI) or magnetoencephalography (MEG), are commonly added as adjuncts for preoperative language mapping but have been shown to have relevant limitations. Thus, this study presents a novel multimodal setup consisting of preoperative navigated transcranial magnetic stimulation (nTMS) and nTMS-based diffusion tensor imaging fiber tracking (DTI FT) as an adjunct to awake surgery.METHODSSixty consecutive patients (63.3% men, mean age 47.6 ± 13.3 years) suffering from highly language-eloquent left-hemispheric low- or high-grade glioma underwent preoperative nTMS language mapping and nTMS-based DTI FT, followed by awake surgery for tumor resection. Both nTMS language mapping and DTI FT data were available for resection planning and intraoperative guidance. Clinical outcome parameters, including craniotomy size, extent of resection (EOR), language deficits at different time points, Karnofsky Performance Scale (KPS) score, duration of surgery, and inpatient stay, were assessed.RESULTSAccording to postoperative evaluation, 28.3% of patients showed tumor residuals, whereas new surgery-related permanent language deficits occurred in 8.3% of patients. KPS scores remained unchanged (median preoperative score 90, median follow-up score 90).CONCLUSIONSThis is the first study to present a clinical outcome analysis of this very modern approach, which is increasingly applied in neurooncological centers worldwide. Although human language function is a highly complex and dynamic cortico-subcortical network, the presented approach offers excellent functional and oncological outcomes in patients undergoing surgery of lesions affecting this network.