bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncertainty quantification, propagation and characterization by Bayesian analysis combined with global sensitivity analysis applied to dynamical intracellular pathway models
Authors: Eriksson Olivia , Jauhiainen Alexandra , Sasane Sara Maad , Kramer Andrei , Nair Anu G , Sartorius Carolina , Kotaleski Jeanette Hellgren 
Published: April 2018

AbstractMotivationDynamical models describing intracellular phenomena are increasing in size and complexity as more information is obtained from experiments. These models are often over-parameterized with respect to the quantitative data used for parameter estimation, resulting in uncertainty in the individual parameter estimates as well as in the predictions made from the model. Here we combine Bayesian analysis with global sensitivity analysis in order to give better informed predictions; to point out weaker parts of the model that are important targets for further experiments, as well as give guidance on parameters that are essential in distinguishing different qualitative output behaviours.ResultsWe used approximate Bayesian computation (ABC) to estimate the model parameters from experimental data, as well as to quantify the uncertainty in this estimation (inverse uncertainty quantification), resulting in a posterior distribution for the parameters. This parameter uncertainty was next propagated to a corresponding uncertainty in the predictions (forward uncertainty propagation), and a global sensitivity analysis was performed on the prediction using the posterior distribution as the possible values for the parameters. This methodology was applied on a relatively large and complex model relevant for synaptic plasticity, using experimental data from several sources. We could hereby point out those parameters that by themselves have the largest contribution to the uncertainty of the prediction as well as identify parameters important to separate between qualitatively different predictions.This approach is useful both for experimental design as well as model building.
All-in-One Adeno-associated Virus Delivery and Genome Editing by Neisseria meningitidis Cas9 in vivo
Authors: Ibraheim Raed , Song Chun-Qing , Mir Aamir , Amrani Nadia , Xue Wen , Sontheimer Erik J. 
Published: April 2018

AbstractClustered, regularly interspaced, short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) have recently opened a new avenue for gene therapy. Cas9 nuclease guided by a single-guide RNA (sgRNA) has been extensively used for genome editing. Currently, three Cas9 orthologs have been adapted for in vivo genome engineering applications: SpyCas9, SauCas9 and CjeCas9. However, additional in vivo editing platforms are needed, in part to enable a greater range of sequences to be accessed via viral vectors, especially those in which Cas9 and sgRNA are combined into a single vector genome. Here, we present an additional in vivo editing platform using Neisseria meningitidis Cas9 (NmeCas9). NmeCas9 is compact, edits with high accuracy, and possesses a distinct PAM, making it an excellent candidate for safe gene therapy applications. We find that NmeCas9 can be used to target the Pcsk9 and Hpd genes in mice. Using tail vein hydrodynamic-based delivery of NmeCas9 plasmid to target the Hpd gene, we successfully reprogrammed the tyrosine degradation pathway in Hereditary Tyrosinemia Type I mice. More importantly, we delivered NmeCas9 with its single-guide RNA in a single recombinant adeno-associated vector (rAAV) to target Pcsk9, resulting in lower cholesterol levels in mice. This all-in-one vector yielded >35% gene modification after two weeks of vector administration, with minimal off-target cleavage in vivo. Our findings indicate that NmeCas9 can facilitate future efforts to correct disease-causing mutations by expanding the targeting scope of RNA-guided nucleases.
Supply chain network optimization with consideration of raw material and final product substitutions driven by price and carbon emissions
Authors: Wang Chuanxu , Li Yanbing , Wang Zhengcai 
Published: April 2018

Purpose
This paper aims to develop a bi-objective mixed integer non-linear programing model to optimize the supply chain networks consisting of raw material providers, final product manufacturers and distribution centers. Raw material substitution caused by varying raw material supply amounts, prices and carbon emissions and final product substitution due to different product prices and carbon emissions are considered.

Design/methodology/approach
The proposed model aims to achieve total profit maximization and total carbon emission minimization. The objective function of carbon emissions is converted into a maximization problem by changing minimum to maximum. The composite objective function is the weighted sum of the bias value of each objective function. The model is then solved using software Lingo12.

Findings
Numerical analysis results show that an increase in the number of alternate raw materials for original raw material helps improve supply chain network performance, and variation in that number causes detectable but not significant changes in downstream final product substitution results.

Originality/value
The major differences between this work and existing research are as follows: first, although previous research considered carbon emissions in supply chain network optimization, it has not considered the substitution effects of products or raw materials. This paper considers the substitution of both raw material and productions. Second, the item substitution considered by previous research is derived from inventory shortage or price difference of original items. However, the substitution considered in the present paper is a response to differences in purchase price, production cost and carbon emissions for items.
Remote chemical sensing: a review of techniques and recent developments
Authors: Bogue Robert 
Published: April 2018

Purpose
This paper aims to provide technical details of the techniques used for the remote detection of chemical compounds in a number of applications and also to highlight key research themes.

Design/methodology/approach
Following a short introduction, this first considers remote gas detection using the DIAL technique. Remote gas cloud imaging is then discussed, and this is followed by a review of chemical warfare agent detection technologies. A selection of research activities and product developments aimed at remotely detecting explosives are considered and, finally, brief concluding comments are drawn.

Findings
Remote gas sensing is now a practical reality, and products are available which can remotely detect, identify, quantify and in some cases visualise a wide range of toxic and environmentally threatening gases. These satisfy numerous industrial, environmental and military applications. Remotely detecting explosives poses a significant technological challenge, and despite some commercialisation, it remains the topic of an extensive research effort, much involving LIBS and Raman techniques. Importantly, much of this work also has potential in non-military applications, with several developments being shown to detect various industrially important compounds.

Originality/value
This provides a technical insight into the techniques and products used in a range of remote chemical sensing applications.
Parents of children referred to a sleep laboratory for disordered breathing reported anxiety, daytime sleepiness and poor sleep quality
Authors: Cadart Marion , De Sanctis Livio , Khirani Sonia , Amaddeo Alessandro , Ouss Lisa , Fauroux Brigitte 
Published: April 2018

AbstractAimWe evaluated the impact that having a child with sleep‐disordered breathing had on their parents, including their own sleep quality.MethodsQuestionnaires were completed by 96 parents of 86 children referred for a sleep study or control of continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) at the sleep laboratory of the Necker Hospital, Paris, France, between October 2015 and January 2016. The questionnaires evaluated anxiety and depression, family functioning, the parents’ quality of life, daytime sleepiness and sleep quality.ResultsThe children had a mean age of seven ±five years and most of the responses (79%) came from their mothers. These showed that 26% of parents showed moderate‐to‐severe anxiety, 8% moderate‐to‐severe depression, 6% complex family cohesion, 59% moderate‐to‐severe daytime sleepiness and 54% poor sleep quality. Anxiety was higher in mothers than in fathers (p < 0.001). The questionnaire scores did not differ according to the child's age, the results of the sleep studies or the CPAP or NIV treatment. The symptoms seem to be more commonly related to the child's underlying disease than their sleep‐disordered breathing.ConclusionThe parents of children referred to a sleep laboratory reported frequent anxiety, daytime sleepiness and poor sleep quality.
Retinopathy of prematurity screening at ≥30 weeks: urinary NTpro‐BNP performance
Authors: Berrington JE , Clarke P , Embleton ND , Ewer AK , Geethanath R , Gupta S , Lal M , Oddie S , Shafiq A , Vasudevan C , Bührer C 
Published: April 2018

AbstractAimUrinary N‐terminal B‐type natriuretic peptide NTproBNP levels are associated with the development of retinopathy of prematurity (ROP) in infants <30 weeks of gestation. The incidence of ROP in more mature infants who meet other ROP screening criteria is very low. We therefore aimed to test whether urinary NTproBNP predicted ROP development in these infants.MethodsProspective observational study in 151 UK infants ≥30 + 0 weeks of gestation but also <32 weeks of gestation and/or <1501 g, to test the hypothesis that urinary NTproBNP levels on day of life (DOL) 14 and 28 were able to predict ROP development.ResultsUrinary NTproBNP concentrations on day 14 and day 28 of life did not differ between infants with and without ROP (medians 144 vs 128 mcg/mL, respectively, p = 0.86 on DOL 14 and medians 117 vs 94 mcg/mL, respectively, p = 0.64 on DOL28).ConclusionThe association previously shown for infants <30 completed weeks between urinary NTproBNP and the development of ROP was not seen in more mature infants. Urinary NTproBNP does not appear helpful in rationalising direct ophthalmoscopic screening for ROP in more mature infants, and may suggest a difference in pathophysiology of ROP in this population.
Piecing Together the American Voting Puzzle: How Voters’ Personalities and Judgments of Issue Importance Mattered in the 2016 Presidential Election
Authors: Blankenship Benjamin T. , Savaş Özge , Frederick Jennifer K. , Stewart Abigail J. 
Published: April 2018

AbstractIn the wake of the 2016 election, which surprised pundits and voters on both the left and the right, there has been renewed interest in understanding what predicts American voters’ choices. In this article, we investigate the roles of personality and issue importance in how people voted in the 2016 U.S. election. In this longitudinal study of 403 MTurk workers who voted in the election, we assessed the relations between personality (openness, social dominance orientation, and national identity importance) and issue importance (group rights and social justice, economic rights, and individual and national rights), and voting for Clinton or Trump. Our results indicate that both individual differences and issue importance as measured in July 2016 predicted votes in November. We also found that the links between personality and voting were mediated by issue importance. Implications for political psychology and the study of personality, campaign issues, and voting behavior are discussed.
PRICE AND QUANTITY COMPETITION WITH ASYMMETRIC COSTS IN A MIXED DUOPOLY: A TECHNICAL NOTE
Authors: Choi Kangsik 
Published: April 2018

ABSTRACTWe consider a mixed duopoly in which private and public firms can choose to strategically set prices or quantities when the public firm is less efficient than the private firm. Thus, even with cost asymmetry, we obtain exactly the same result (i.e., Bertrand competition) of Matsumura and Ogawa (2012) if Singh and Vives’ (1984) assumption of positive primary outputs holds. However, compared to endogenous determination of the type of contract without cost asymmetry, our main finding is that in the wider range of cost asymmetry, different type(s) of equilibrium related to or not related to the limit‐pricing strategy of the private firm can be sustained. Thus, when considering an implication on privatization, we may overestimate the welfare gain of privatization because Cournot competition takes place after privatization even though cost asymmetry exists between firms. While the result of Matsumura and Ogawa (2012) holds true if the goods are complements, we find the novel results in the case of substitutes.
Patient experience of centralized acute stroke care pathways
Authors: Perry Catherine , Papachristou Iliatha , Ramsay Angus I.G. , Boaden Ruth J. , McKevitt Christopher , Turner Simon J. , Wolfe Charles D.A. , Fulop Naomi J. 
Published: April 2018

AbstractBackgroundIn 2010, Greater Manchester (GM) and London centralized acute stroke care services into a reduced number of hyperacute stroke units, with local stroke units providing on‐going care nearer patients’ homes.ObjectiveTo explore the impact of centralized acute stroke care pathways on the experiences of patients.DesignQualitative interview study. Thematic analysis was undertaken, using deductive and inductive approaches. Final data analysis explored themes related to five chronological phases of the centralized stroke care pathway.Setting and participantsRecruitment from 3 hospitals in GM (15 stroke patients/8 family members) and 4 in London (21 stroke patients/9 family members).ResultsParticipants were impressed with emergency services and initial reception at hospital: disquiet about travelling further than a local hospital was allayed by clear explanations. Participants knew who was treating them and were involved in decisions. Difficulties for families visiting hospitals a distance from home were raised. Repatriation to local hospitals was not always timely, but no detrimental effects were reported. Discharge to the community was viewed less positively.Discussion and conclusionsPatients on the centralized acute stroke care pathways reported many positive aspects of care: the centralization of care pathways can offer patients a good experience. Disadvantages of travelling further were perceived to be outweighed by the opportunity to receive the best quality care. This study highlights the necessity for all staff on a centralized care pathway to provide clear and accessible information to patients, in order to maximize their experience of care.
Time to abandon the loss of dispersal ability hypothesis in island plants: A comment on García‐Verdugo, Mairal, Monroy, Sajeva and Caujapé‐Castells (2017)
Authors: Burns K.C. 
Published: April 2018

AbstractGarcía‐Verdugo et al. (2017) recently tested the loss of dispersal ability hypothesis in a wind‐dispersed shrub from Southern Europe. Although the hypothesis has guided research for over 150 years, García‐Verdugo et al. (2017) results failed to substantiate its central prediction—the loss of seed dispersal potential in island populations. Here, I highlight several additional limitations of the hypothesis. First, García‐Verdugo et al. (2017) results are not unusual. Empirical support for the hypothesis is equivocal. Second, when reduced dispersal potential is documented, it may often evolve as a passive by‐product of selection for large seeds, for reasons that are wholly unrelated to their dispersal. Third, the hypothesis does not readily apply to all plant dispersal modes, particularly plants that produce fleshy fruits. These issues advocate a fresh approach to the study of how selection shapes the evolution of dispersal potential on islands.
Radiofrequency Thermocoagulation of the Ganglion Impar for Coccydynia Management: Long‐Term Effects
Authors: Kırcelli Atilla , Demirçay Emre , Özel Ömer , Çöven Ilker , Işık Semra , Civelek Erdinç , Kabataş Serdar 
Published: April 2018

AbstractObjectiveTo investigate the short‐ and long‐term effects of ganglion impar radiofrequency thermocoagulation (RFT) treatment in patients with chronic coccydynia.MethodsWe retrospectively analyzed the medical records of patients who underwent RFT of the ganglion impar between 2009 and 2011. Pain intensity visual numeric scale (VNS) scores and Euroqol 5D (EQ‐5D) index scores were recorded pre‐intervention and post‐intervention at the first, sixth, and twelfth months. The differences between pre‐procedural VNS scores and post‐procedural VNS scores at the first, sixth, and twelfth months were evaluated. The success of the intervention was recorded as the percentage difference between the pre‐intervention VNS scores and post‐intervention VNS scores at the first, sixth, and twelfth months.ResultsThe mean age of the patients, including 11 females (55%) and 8 males (45%), was 48.7 ± 14.3 years. The average follow‐up duration was 17.3 ± 2.9 months. Statistically significant differences were observed between the pre‐ and post‐procedure VNS scores (P < 0.0001). Improvements in VNS scores were correlated with improvements in EQ‐5D index scores. Mid‐term (sixth month) and long‐term (twelfth month) evaluations after the intervention revealed that 67.4% and 61.1% of the patients had successful outcomes, respectively.ConclusionOur data suggested that RFT of the ganglion impar in patients with chronic coccydynia resulted in effective outcomes, and patients who responded to RFT had significantly lower post‐RFT pain scores.
Social goals moderate the associations between peer status and behavior in middle school
Authors: Mayeux Lara , Kraft Caroline 
Published: April 2018

AbstractThis study investigated the associations among popularity, agentic and communal social goals, and overt and relational aggression in adolescence, with a focus on social goals as moderators of the association between aggression and popularity. Three hundred eighteen sixth‐, seventh‐, and eighth‐grade students completed a sociometric assessment of overt and relational aggression, prosocial behavior, and popularity, and the Interpersonal Goals Inventory for Children (IGI‐C; Ojanen, Grönroos, & Salmivalli, Developmental Psychology, 41(5), 699–710, 2005). Endorsing agentic goals moderated the association between popularity and both overt aggression and prosocial behavior. Adolescents who were both popular and who endorsed agentic goals were particularly high in overt aggression and prosocial behavior. Communal goals also moderated the popularity‐aggression link, but in different ways depending on the type of aggression being analyzed. We also found evidence that, among adolescents who endorse both types of goals, agentic goals may overshadow communal values. Some of these interactions were further qualified by gender.
Reviewer Acknowledgements
Authors: Smith Robert 
Published: April 2018

Journal of Education and Training Studies (JETS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JETS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 6, Number 3a Carmen Pérez-Sabater, Universitat Poltècnica de València, SpainErica D. Shifflet-Chila, Michigan State University, USAGunkut Mesci, Giresun University, TurkeyJohn Bosco Azigwe, Bolgatanga Polytechnic, GhanaLaura Bruno, The College of New Jersey, USALisa Marie Portugal, Grand Canyon University, USAMehmet Inan, Marmara University, TurkeyNicole Celestine, The University of Western Australia, Australia Robert SmithEditorial AssistantOn behalf of,The Editorial Board of Journal of Education and Training StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://jets.redfame.com
Complete Genome Sequence of a New Ruminococcaceae Bacterium Isolated from Anaerobic Biomass Hydrolysis
Authors: Hahnke Sarah , Abendroth Christian , Langer Thomas , Codoñer Francisco M. , Ramm Patrice , Porcar Manuel , Luschnig Olaf , Klocke Michael 
Published: April 2018

ABSTRACT

A new
Ruminococcaceae
bacterium, strain HV4-5-B5C, participating in the anaerobic digestion of grass, was isolated from a mesophilic two-stage laboratory-scale leach bed biogas system. The draft annotated genome sequence presented in this study and 16S rRNA gene sequence analysis indicated the affiliation of HV4-5-B5C with the family
Ruminococcaceae
outside recently described genera.
Draft Genome Sequences of Megaplasmid-Bearing Streptomyces sp. Strains BF-3 and 4F, Isolated from the Great Salt Plains of Oklahoma
Authors: Cornell Carolyn R. , Marasini Daya , Fakhr Mohamed K. 
Published: April 2018

ABSTRACT

Draft genome sequences of megaplasmid-bearing
Streptomyces
sp. strains BF-3 and 4F, isolated from the Great Salt Plains of Oklahoma, showed genome sizes of 7,950,134 and 7,550,992 bp, respectively. Both genomes revealed the presence of genes involved in osmoregulation and stress response, potentially helping their survival in such an extreme environment.
Complete Genome Sequence of Lactobacillus plantarum subsp. plantarum Strain LB1-2, Isolated from the Hindgut of European Honeybees, Apis mellifera L., from the Philippines
Authors: Ilagan-Cruzada M. Fatima C. , Rosana Albert Remus R. , Montecillo Andrew D. , Sabino Noel G. , Dalmacio Ida F. 
Published: April 2018

ABSTRACT

Lactobacillus plantarum
subsp.
plantarum
strain LB1-2, isolated from the hindgut of European honeybees in the Philippines, is active against
Paenibacillus larvae
and has broad activity against several Gram-positive and Gram-negative bacteria. The complete genome sequence reported herein contains gene clusters for multiple bacteriocins and extensive gene inventories for carbohydrate metabolism.
Draft Genome Sequence of Bowmanella denitrificans JL63, a Bacterium Isolated from Whiteleg Shrimp (Litopenaeus vannamei) That Can Inhibit the Growth of Vibrio parahaemolyticus
Authors: LaPorte Jason P. , Spinard Edward J. , Gomez-Chiarri Marta , Rowley David C. , Mekalanos John J. , Nelson David R. 
Published: April 2018

ABSTRACT

Bowmanella denitrificans
strain JL63 was isolated from a whiteleg shrimp (
Litopenaeus vannamei
) and was determined to have antibacterial activity against an acute hepatopancreatic necrosis disease (AHPND) strain of
Vibrio parahaemolyticus
. Here, we report the draft genome sequence of this strain and identify genes that are potentially involved in its antibacterial activity.