bluuebunny/crossref_metadata_2025_split huggingface dataset:
INTERACTION EFFECTS OF LITSEA CUBEBA ESSENTIAL OIL AND ANTIBIOTICS ON ANTIBACTERIAL ACTIVITY AGAINST PATHOGENIC BACTERIA IN AQUACULTURE
Authors: Nguyen Hai Van 
Published: April 2018

In this study, the interaction effects of Litsea cubeba essential oil (EO) and two antibiotics (ABs) on the antibacterial activity against pathogenic bacteria in aquaculture were investigated. Two reference strains (Escherichia coli ATCC 25922 (E. coli ATCC 25922) and Vibrio parahaemolyticus ATCC 17802 (V. parahaemolyticus ATCC 17802)) and six locally isolated aquatic pathogenic strains (E. coli 9C48, E. coli 11C123, Vibrio 2S4, Vibrio 2N38, V. parahaemolyticus ND201 and V. parahaemolyticus TB81) were used. The inhibitory effects of individual antimicrobial agent (L. cubeba EO, nalidixic acid, and oxytetracycline) were tested against eight strains by using broth microdilution assay in 96-well microplates. A higher inhibitory effect of L. cubeba EO was observed against isolated aquatic pathogenic (MIC = 1.15 - 2.30 mg/mL) than that in the reference strains (MIC = 5.53 mg/mL). The combination effects of L. cubeba EO and ABs often used in the treatment of bacteria effects in aquaculture (nalidixic acid and oxytetracycline) were evaluated by the checkerboard method. Fractional Inhibitory Concentration (FIC) values were determined to characterize the interaction among combinations. Out of 16 AB-EO combinations tested, 11 of them showed a synergistic effect (FIC ≤ 0.5), 3 of them showed an additional effect (0.5 < FIC ≤ 1.0) and 2 of them showed indifferent effect (1 < FIC ≤ 4), no antagonistic effect was observed. The antimicrobial synergy of EO and AB could enhance efficacy, reduce toxicity, decrease adverse side effects, and lower the dose of ABs used in aquaculture.
DISTRIBUTION AND ANTIMICROBIAL ACTIVITY OF ENDOPHYTIC ACTINOMYCETES ISOLATED FROM Litsea cubeba (Lour.) Pers. IN NORTHERN PROVINCES OF VIETNAM
Authors: Lam Pham Ngoc 
Published: April 2018

Endophytic actinomycetes from medicinal plants have been recently reported as the potential producers of antibiotics, anticancer agents and other bioactive compounds. In this study, the distribution and antimicrobial activity of endophytic actinomycetes isolated from Listea cubeba (Lour.) Pers. were investigated. Consequently, the antimicrobial activities of endophytic isolates against eight pathogens, consisting of Salmonella enterica ATCC 14028, Escherichia coli ATCC 11105, Sarcina lutea CNLM, Bacillus cereus ATCC 11778, Proteus vulgaris CNLM, Pseudomonas aeruginosa CNLM, Staphylococcus epidermidis ATCC 12228, Enterobacter aerogenes ATCC 13048 were tested. Total 143 actinomycetes strains were isolated from L. cubeba tissues, in which 53, 23 and 67 strains were respectively obtained from plant samples collected in Thanh Hoa, Hanoi and Phu Tho provinces. Among media used for isolation, the highest number endophytes were from two main media including HV (18.2 %) and SA (16.1 %). Assessment of strains isolated from three kinds of plant tissues, most of endophytes were from roots (n = 65, 45.5 %) and followed by stems (n = 41, 28.7 %) and leaves (n = 37, 25.9 %). Examination of antimicrobial activity of endophytes revealed that 32.9 % of total strains showed inhibitory activity against at least one of the eight tested pathogenic microorganisms. The obtained results indicated that the L. cubeba (Lour.) Pers. could be an extremely rich reservoir for isolation of diverse actinobacteria producing antimicrobial activities and other bioactive compounds.
Laboratory-Based Biomarkers and Liver Metastases in Metastatic Castration-Resistant Prostate Cancer
Authors: Cotogno Patrick M. , Ranasinghe Lahiru K. , Ledet Elisa M. , Lewis Brian E. , Sartor Oliver 
Published: April 2018

Abstract

Background
Metastatic castrate-resistant prostate cancer (mCRPC) patients with liver metastases have a poor prognosis. No large studies have investigated the clinical and biochemical parameters associated with liver metastases in this population.

Materials and Methods
Patient data made available via Project Data Sphere were collected from 1,281 men with mCRPC who were enrolled on to three phase III clinical trials for the treatment of their disease. Multiple logistic regression was performed on eight clinical and biochemical baseline variables to test their association with the presence of liver metastases on baseline radiographic imaging. Variables of interest included prior docetaxel exposure, Eastern Cooperative Oncology Group performance status, albumin, alkaline phosphatase, alanine transaminase, aspartate transaminase (AST), hemoglobin (HGB), lactate dehydrogenase (LDH), prostate-specific antigen, and total bilirubin. Final models were compared when treating the variables as either continuous or categorized.

Results
Multiple variable analysis demonstrated that an increasing serum AST or LDH or a decreasing HGB was associated with an increased probability of having documented radiographic liver metastases (p &lt; .0001). The area under the curve for the continuous model was 0.6842 and 0.6890 for the categorical one, with the latter model containing a dichotomized AST and LDH based on the upper limit of normal and tertile ranges of HGB based on the distribution of the outcome.

Conclusion
Our analysis demonstrated a significant association between the presence of liver metastases and laboratory levels of AST, LDH, and HGB. These have implications for patient management. More research is needed to validate these biomarkers and prospectively determine their application in the clinical setting.

Implications for Practice
The purpose of this study was to evaluate biochemical and clinical biomarkers associated with the presence of liver metastases in men diagnosed with metastatic castrate-resistant prostate cancer. The results indicate that quantitative assessments of aspartate transaminase, lactate dehydrogenase, and hemoglobin are significantly associated with an increased probability of having documented radiographic liver metastases. Analysis of these simple variables can alert clinicians to those at high risk for prostate cancer that has spread to the liver, a finding of clear importance for clinical management.
Clinical Utility of Analyzing Circulating Tumor DNA in Patients with Metastatic Colorectal Cancer
Authors: Nakamura Yoshiaki , Yoshino Takayuki 
Published: April 2018

AbstractMultiple genomic changes caused by clonal evolution induced by therapeutic pressure and corresponding intratumoral heterogeneity have posed great challenges for personalized therapy against metastatic colorectal cancer (mCRC) in the past decade. Liquid biopsy has emerged as an excellent molecular diagnostic tool for assessing predominant spatial and temporal intratumoral heterogeneity with minimal invasiveness.Previous studies have revealed that genomic alterations in RAS, BRAF, ERBB2, and MET, as well as other cancer-related genes associated with resistance to anti-epidermal growth factor receptor (EGFR) therapy, can be analyzed with high diagnostic accuracy by circulating tumor DNA (ctDNA) analysis. Furthermore, by longitudinally monitoring ctDNAs during anti-EGFR therapy, the emergence of genomic alterations can be detected as acquired resistance mechanisms in specific genes, mainly those associated with the mitogen-activated protein kinase signaling pathway. Analysis of ctDNA can also identify predictive biomarkers to immune checkpoint inhibitors, such as mutations in mismatch repair genes, microsatellite instability-high phenotype, and tumor mutation burden. Some prospective clinical trials evaluating targeted agents for genomic alterations in ctDNA or exploring resistance biomarkers by monitoring of ctDNA are ongoing.To determine the value of ctDNA analysis for decision-making by more accurate molecular marker-based selection of patients and identification of resistance mechanisms to targeted therapies or sensitive biomarkers for immune checkpoint inhibitors, clinical trials must be refined to evaluate the efficacy of study treatment in patients with targetable genomic alterations confirmed by ctDNA analysis, and resistance biomarkers should be explored by monitoring ctDNA in large-scale clinical trials. In the near future, ctDNA analysis will play an important role in precision medicine for mCRC.Implications for PracticeTreatment strategies for metastatic colorectal cancer (mCRC) are determined according to the molecular profile, which is confirmed by analyzing tumor tissue. Analysis of circulating tumor DNA (ctDNA) may overcome the limitations of tissue-based analysis by capturing spatial and temporal intratumoral heterogeneity of mCRC. Clinical trials must be refined to test the value of ctDNA analysis in patient selection and identification of biomarkers. This review describes ctDNA analysis, which will have an important role in precision medicine for mCRC.
Comprehensive Molecular Characterization of Young Chinese Patients with Lung Adenocarcinoma Identified a Distinctive Genetic Profile
Authors: Hou Helei , Zhu Hua , Zhao Han , Yan Weihua , Wang Yongjie , Jiang Man , Liu Bin , Liu Dong , Zhou Na , Zhang Chuantao , Li Pansong , Chang Lianpeng , Guan Yanfang , Wang Zhe , Zhang Xiaoping , Li Zhuokun , Fang Bingliang , Zhang Xiaochun 
Published: April 2018

Abstract

Background
Occurrence at a younger age has been demonstrated to be associated with a distinct biology in non-small cell lung cancer. However, genomics and clinical characteristics among younger patients with lung adenocarcinoma remain to be determined. Here we studied the potentially targetable genetic alterations by next-generation sequencing (NGS) assay in young Chinese patients with lung adenocarcinoma.

Materials and Methods
Seventy-one surgically resected lung adenocarcinoma tissue samples from patients aged less than 45 years were collected with informed consent from all patients. Targeted NGS assays were used to identify actionable genetic alterations in the cancer tissues. Additionally, the genomic and clinicopathologic characteristics of 106 patients with lung adenocarcinoma who received NGS testing over the same period were analyzed retrospectively.

Results
The frequencies of targetable genetic alterations in 177 patients with lung adenocarcinoma were analyzed by defined age categories, which unveiled a distinctive molecular profile in the younger group, aged less than 45 years. Notably, higher frequency of ALK and HER2 genetic alterations were associated with young age. However, a reverse trend was observed for KRAS, STK11 and EGFR exon 20 mutations, which were more frequently identified in the older group, aged more than 46 years. Furthermore, concurrent EGFR/TP53 mutations were much more prevalent in the younger patients (81.6% vs. 46.8%), which might have a poor response to treatment with epidermal growth factor receptor tyrosine kinase inhibitor.

Conclusion
In this study, NGS assay revealed a distinctive genetic profile in younger patients with adenocarcinoma. High frequency of concurrent EGFR/TP53 mutations was found in the younger patients, which especially warranted personalized treatment in this population.

Implications for Practice
Further investigation is needed to understand the genomics and clinical characteristics of young patients with lung adenocarcinoma. In the present study, hybrid capture-based next-generation sequencing assays were used to identify targeted genetic alterations in young lung adenocarcinoma patients. Young patients with lung adenocarcinoma, aged less than 45 years, harbored a higher frequency of ALK and HER2 genetic alterations compared with patients aged more than 46 years. Dramatically, concurrent EGFR/TP53 mutations were much more prevalent in younger patients, which had a poor response to treatment with epidermal growth factor receptor kinase inhibitor. These results reveal a distinctive genetic profile in younger patients with adenocarcinoma, which might improve the treatment of this subpopulation.
The Effect of Visual Contextual Support and Glossary of Words on Guessing Meaning of New Vocabulary Items in English by Pre-university Male EFL Students
Authors: Nasrollahi Kamal , Daneshfar Samran 
Published: April 2018

The present study aims at investigating the impact of visual contextual support and Glossary of Words on EFL learners’ vocabulary learning. For this purpose, a total number of 60 male pre-university students were randomly selected after administering the English proficiency test to assure the homogeneity of the participants. The learners were assigned to three homogeneous groups, 2 experimental groups, namely, visual contextual support and glossary of words and one control group to highlight the comparative purposes. During treatment, the first experimental group received a passage including new vocabulary items and visual contextual supports as treatment and the second experimental group received the same passage including new vocabulary items and the glossary of words as treatment. On the other hand, the control group received no treatment and they were just given the new vocabulary items of the same passages given to the experimental groups in order to guess the meaning of new words only by using their own vocabulary knowledge. To compare the probable differential impact of the study a pretest and posttest were applied to all three groups and the results of the tests were contrasted and analysed. For data analysis, the one-way ANOVA was administered for pretest and posttest. The results of the study demonstrated a significant improvement of vocabulary learning through utilizing visual contextual support in comparison to the glossary of words group and moreover than the control group.
Redes de Atenção à Saúde: Movimentos do Ensino e Serviço Rumo à Efetivação do Modelo Assistencial
Authors: Maffissoni André Lucas , Vendruscolo Carine , Metelski Fernanda Karla 
Published: April 2018

Revisão integrativa da literatura, que objetivou caracterizar as produções bibliográficas sobre Redes de Atenção à Saúde no Brasil entre o período de 2005 e 2015. Na busca dos trabalhos, ocorrida em janeiro de 2016, utilizaram-se os termos: “Redes de Atenção à Saúde” e “Assistência à Saúde”, no portal Biblioteca Virtual em Saúde. Um total de 16 produções, que se relacionavam ao tema proposto foram selecionadas e divididas, em duas temáticas de discussão: “As Redes e sua implicação no modelo de atenção à saúde” e “A participação dos diferentes setores e sujeitos para a efetivação das Redes”. Os artigos discutem acerca das potencialidades, que um sistema operacionalizado na dinâmica de Redes pode trazer para a atenção em saúde, bem como revelam a importância do envolvimento do setor ensino no processo de construção e consolidação destas, em decorrência de sua função de notável importância nos processos formativos de futuros profissionais da saúde. As publicações também demonstram diversas dificuldades na concretização desse modelo de atenção, o que advém da falta de conscientização e adesão ao modelo, por parte dos sujeitos, que atuam diretamente ou indiretamente no Sistema de Saúde, incluindo-se profissionais, estudantes, professores, usuários e gestores. Foi encontrado um número limitado de artigos científicos, o que demonstra necessidade de ampliar as pesquisas na área.Palavras-chave: Redes de Atenção à Saúde. Assistência à Saúde. Educação em Saúde.AbstractIntegrative review of literature that aims to characterize the bibliographic productions about Health Care Networks in Brazil between the period of 2005 and 2015. The search of the articles, collected in January of 2016, included the terms “Health Care Networks” and “Delivery of Health Care”, on Health Library Virtual portal. An entire of 16 publications that were related to the proposed theme were selected and divided into two thematic discussions: “The impact produced by Networks on health care system” and “The participation of different sectors and people to the Networks establishment”. The articles discuss about the potential that an operationalized system in Networks dynamics can bring to health care as well as reveal the importance of the education sector involvement concerning the construction and consolidation of the same, due to their remarkable importance when it comes to theformation process of future health professionals. The publication also demonstrates several difficulties achieving this care model, which arise from the lack of awareness and accession to the model by the subjects that act directly or indirectly on the Health System, including professional, students, professors and managers. A limited number of scientific articles were found which shows the need to expand the researches in this area.Keywords: Health Care Networks. Health Delivery. Health Education.
Tempo de Chegada do Paciente Infartado na Unidade de Terapia Intensiva: a Importância do Rápido Atendimento
Authors: Ouchi Janaina Daniel , Teixeira Cintia , Góes Ribeiro César Augusto , Oliveira Cibeli Cristina 
Published: April 2018

Baseado em um estudo já realizado, em que se abordava a importância do rápido atendimento de Emergência ao paciente infartado ou com suspeita de Infarto Agudo do Miocárdio (IAM), surgiu a motivação para realizar este trabalho em que se abordará a continuação do atendimento nas Unidades de Terapia Intensiva ao paciente infartado, mostrando que o rápido atendimento, diagnóstico e encaminhamento para o centro de referência será primordial na posterior recuperação do paciente. De acordo com a IV Diretriz da Sociedade Brasileira de Cardiologia sobre Tratamento do Infarto Agudo do Miocárdio (IAM), a maioria das mortes nesta condição ocorre nas primeiras horas de manifestação da doença, sendo 40% a 65% na primeira hora e, aproximadamente, 80% nas primeiras 24 horas. Esse é um dos fatos que demonstram a importância do domínio pelos profissionais da saúde dos sinais e sintomas iniciais do IAM e a importância da tomada de decisão imediata para minimizar ou zerar os danos decorrentes de um infarto ao paciente.Palavras-chave: Cardiologia. Infarto Agudo do Miocárdio. Protocolo. Unidades de Terapia Intensiva.AbstractBased on a study already carried out that addressed the importance of quick response of emergency to patients with myocardial infarction or suspected AMI, motivation arose to carry out this work which will address the continued care in Intensive Care Units to patients with myocardial infarction, showing that quick service, diagnosis and referral to the reference center will be paramount in the subsequent recovery of the patient. According to IV Guidelines of the Brazilian Cardiology Society for Treatment of Acute Myocardial Infarction, most deaths in AMI occurs in the first hours of disease onset, 40% to 65% in the first hour and approximately 80% in first 24 hours. This is one of the facts that demonstrate the importance of the field by health professionals of the initial signs and symptoms of AMI and the importance of taking immediate decision to minimize or zero damage from a heart attack patient.Keywords: Cardiology. Acute Myocardial Infarction. Protocol. Intensive Care Unit.
Global field experiments for potato simulations
Authors: Raymundo Rubi , Asseng Senthold , Prasad Rishi , Kleinwechter Ulrich , Condori Bruno , Bowen Walter , Wolf Joost , Olesen Jørgen E. , Dong Qiaoxue , Zotarelli Lincoln , Gastelo Manuel , Alva Ashok , Travasso Maria , Arora Vijay 
Published: April 2018

A large field potato experimental data set has been assembled for simulation modeling. The data are from temperate, subtropical, and tropical regions across the world and include 87 experiments with 204 treatments. Treatments include nitrogen fertilizer, irrigation, atmospheric CO2 levels, temperature, cultivars, and locations. For all experiments, measurements include tuber fresh and dry weight. For some experiments, measurements include in-season biomass, leaf area index, stem and leaf weight, N uptake, soil water, and soil N contents. Each experiment has soil characteristics and daily data for solar radiation, rainfall, and maximum and minimum temperature. The data have been quality checked and used in a previous simulation exercise. All data are in AGMIP format. Data access via doi 10.7910/DVN/4KJ5ME.
Sublocations of cancers of the oral cavity, oropharynx, hypopharynx, larynx, primary lymph node and other epidemiological features in a French Tropical Island in the Indian Ocean 2009-2013
Authors: Delagranda Antoine , Ferreira Romain , Dufour Xavier , Poisson Maria , Leterme Gaelle 
Published: April 2018

<p class="abstract"><strong>Background:</strong> This study had two objectives: firstly, to describe and compare sublocations of all cancer of the oral cavity, oropharynx, hypopharynx, larynx and primary carcinoma cervical lymph node diagnosed in Reunion Island, a tropical French overseas territory in the southern hemisphere between 2009 to 2013; and secondly others epidemiological features.</p><p class="abstract"><strong>Methods:</strong> A retrospective study included 621 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx or primary cervical node between 2009 and 2013 in Reunion Island. 13 possible sublocations of cancer for mouth are described, 14 for larynx, 12 for oropharynx, 3 for hypopharynx, 8 for primary cervical lymph node. Demographic characteristics, data on alcohol consumption, smoking habits, HPV infection, denutrition were analyzed. </p><p class="abstract"><strong>Results:</strong> Cancer location consisted of oropharynx (36.2%), larynx (25.6%), oral cavity (20.8%), hypopharynx (13.8%), primary carcinoma lymph node (3.6%). Sublocations in oral cavity mainly concerned palatin tonsil and base tongue. Vocal fold was the mostly frequent sublocation involved in larynx. Cancer in oral cavity were portion out more homogeneously. Excluding primary lymph node, sex ratio was 7.7 and mean age was 60 years. Cancer consisted of squamous cell carcinoma in 99.1% of patients. 340/375 patients (81.25%) showed alcohol abuse; 309/359 (86.1%) were smokers; 31/184 (16.8%) had HPV infection.</p><p class="abstract"><strong>Conclusions:</strong> First study including all cases of pharyngolarynx and oral cavity cancer and depicting all sublocations involved in one series. We found no significant difference of distribution between sublocations for larynx but some for oropharynx and oral cavity compared to literature.</p><p class="abstract"> </p>