bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanics of L5/S1 in Long Thoracolumbosacral Constructs: A Cadaveric Study
Authors: Lee Bryan S. , Walsh Kevin M. , Healy Andrew T. , Colbrunn Robb , Butler Robert S. , Goodwin Ryan C. , Steinmetz Michael P. , Mroz Thomas E. 
Published: March 2018

Study Design: In vitro cadaveric biomechanical study. Objectives: Despite numerous techniques employed to establish solid lumbosacral fixation, there are little biomechanical data correlating fixation methods at L5/S1 to thoracolumbosacral (TLS) construct length. We aimed to determine the optimal construct with the hypothesis that under physiological loads, lumbosacral constructs can be stabilized by L5/S1 anterior lumbar interbody fusion (ALIF) alone, without iliac screw fixation (ISF), and that TLS constructs would require ISF, with or without ALIF. Methods: By using a robot capable of motion in 6 axes, force-moment sensor, motion-tracking camera system and software, we simulated the spinal loading effects in flexion-extension, axial rotation, and lateral bending, and compared torques in different construct groups of T4-S1, T10-S1, and L2-S1. By conducting multidirectional flexibility testing we assessed the effects of constructs of various lengths on the L5/S1 segment. Results: L2-S1 constructs may be equivalently stabilized by L5/S1 ALIF alone without ISF. Longer TLS constructs exerted increasing motion at L5/S1, exhibiting trends in favor of ISF when extending to T10 and statistically improved fixation when extending to T4. Lastly, TLS constructs with ISF exhibited a statistically significant reduction in L5-S1 range of motion from the addition of ALIF when extending to T4-pelvis but not T10-pelvis. Conclusions: We found that ALIF alone may sufficiently support the L2-S1 construct, reducing L5/S1 range of motion and transmitting loads instead to the sacropelvis. Furthermore, ALIF was found to add significant stability to the T4-pelvis construct when added to ISF. This difference was not significant for the T10-pelvis construct.
Nutrition Education in Internal Medicine Residency Programs and Predictors of Residents’ Dietary Counseling Practices
Authors: Khandelwal Stutee , Zemore Sarah E , Hemmerling Anke 
Published: March 2018

Background: Although physicians are expected to provide dietary counseling for patients with cardiovascular (CV) risk factors such as hypertension, hyperlipidemia, diabetes, and obesity, nutrition education in graduate medical education remains limited. Few studies have recently examined nutrition education and dietary counseling practices in Internal Medicine (IM) residency training. Objectives: To conduct a contemporary assessment of outpatient nutrition education in IM residency programs in the United States, identify predictors of residents’ dietary counseling practices for CV risk factors, and identify barriers for educators in providing nutrition education and barriers for residents in counseling patients. Design: Cross-sectional anonymous surveys were completed by IM program directors (PDs) and residents throughout the United States. Linear regression was used to examine the association between the amount of nutrition education received and the number of instruction methods used by the residents and frequency of residents’ dietary counseling for patients with CV risk factors. Key Results: A total of 40 educators (PDs and ambulatory/primary care PDs) and 133 residents across the United States responded to the survey. About 61% of residents reported having very little or no training in nutrition. Nutrition education in residency, both the amount of education (β = 0.20, P = .05) and the number of instruction methods used (β = 0.26, P = .02), predicted frequency of residents’ dietary counseling practices independent of nutrition education in medical school, which was also significantly associated with counseling (β = 0.20, P = .03). Residents’ total fruit and vegetable intake likewise predicted frequency of counseling (β = 0.24, P < .001). Low perceived faculty expertise was a major barrier for educators and was associated with lower level of provided nutrition education ( r = −.33, P = .04). Low resident and low perceived clinic preceptors’ interests in nutrition were also associated with lower frequency of residents’ dietary counseling ( r = −.19, P = .04; r = −.18, P = .05). Conclusions: The provision of nutrition education in IM residency programs and IM residents’ dietary counseling for patients need to be systematically assessed nationally. This study’s preliminary findings suggest that multimodal nutrition education in IM residency and better resident dietary habits are associated with higher frequency of dietary counseling for patients. Lack of faculty expertise and low faculty and resident interests in patient counseling need to be addressed perhaps by mandating nutrition education in graduate and continuing medical education.
Epigenetic programming of T cells impacts immune reconstitution in hematopoietic stem cell transplant recipients
Authors: Hardy Kristine , Smith Corey , Tu Wen Juan , McCuaig Robert , Panikkar Archana , Dasari Vijayendra , Wu Fan , Tey Siok-Keen , Hill Geoffrey R. , Khanna Rajiv , Rao Sudha 
Published: March 2018

Key Points
Identification of molecular signatures in CMV-specific T cells from HSCT recipients with stable vs unstable immune reconstitution. Inhibiting epigenetic regulators, like JARID2 or HDAC6, may be a promising strategy for modifying immune reconstitution in HSCT recipients.
What Are We Really Good At? Product Strategy with Uncertain Capabilities
Authors: Miklós-Thal Jeanine , Raith Michael , Selove Matthew 
Published: March 2018

Firms often learn about their own capabilities through their products’ successes and failures. This paper explores the interaction between learning about capabilities and product strategy in a formal model. We consider a firm that can launch a sequence of products, where each product’s success probability depends on the fit between the firm’s capabilities and the product. A successful new product always causes the firm to become more optimistic about the capability most relevant for that product; however, it can also cause the firm to become less optimistic about some of its other capabilities, including capabilities the new product does not use. The firm’s optimal forward-looking product strategy accounts for short-run expected profits as well as for the information value of learning for future decisions. We find that a product sharing few or even no capabilities with potential future products can have a greater information value than a product that shares more capabilities with future products and that learning about capabilities can affect the optimal sequence of product launch decisions.Data and the online appendix are available at https://doi.org/10.1287/mksc.2017.1068 .
OR.NET: a service-oriented architecture for safe and dynamic medical device interoperability
Authors: Kasparick Martin , Schmitz Malte , Andersen Björn , Rockstroh Max , Franke Stefan , Schlichting Stefan , Golatowski Frank , Timmermann Dirk 
Published: March 2018

Abstract
Modern surgical departments are characterized by a high degree of automation supporting complex procedures. It recently became apparent that integrated operating rooms can improve the quality of care, simplify clinical workflows, and mitigate equipment-related incidents and human errors. Particularly using computer assistance based on data from integrated surgical devices is a promising opportunity. However, the lack of manufacturer-independent interoperability often prevents the deployment of collaborative assistive systems. The German flagship project OR.NET has therefore developed, implemented, validated, and standardized concepts for open medical device interoperability. This paper describes the universal OR.NET interoperability concept enabling a safe and dynamic manufacturer-independent interconnection of point-of-care (PoC) medical devices in the operating room and the whole clinic. It is based on a protocol specifically addressing the requirements of
device-to-device communication, yet also provides solutions for connecting the clinical information technology (IT) infrastructure. We present the concept of a service-oriented medical device architecture (SOMDA) as well as an introduction to the technical specification implementing the SOMDA paradigm, currently being standardized within the IEEE 11073 service-oriented device connectivity (SDC) series. In addition, the Session concept is introduced as a key enabler for safe device interconnection in highly dynamic ensembles of networked medical devices; and finally, some security aspects of a SOMDA are discussed.
Alveolar Bone Resorption Evaluation Around Single-piece Designed Bicortical Implants, Using Immediate Loading Protocol, Based on Orthopantomographs
Authors: Száva Dániel-Tamás , Ormenișan Alina , Markovics Emese , Bögözi Bálint , Mártha Krisztina 
Published: March 2018

Abstract

Background: Inserting dental implants in severely atrophied jawbones is a great challenge for the dental practitioner. There are an increasing number of patients who choose dental implantanchored prosthetic restorations despite compromised bone quality and quantity. There have been numerous attempts in adapting implant design for the atrophic crestal bone. One-piece, needle-type basal implant design is a typical design for these cases. These implants are inserted in the remaining compact bone located in the basal aspect of the jawbones. If high primary stability is achieved, these implants are used for immediate loading protocol. From many points of view, this technique is based on contradictory principles compared to classic implant surgery and loading protocols. The aim of this study was to investigate the long-term success of basal one-piece short-diameter dental implants used for immediate loading protocol.

Materials and methods: A total of 56 dental implants were included in this study. Peri-implant bone loss was measured on orthopantomographs. Bone resorption was measured in millimeters in the first 6 and 12 months of functional loading.

Results: There were no failing implants in this period; average bone resorption was 1.59 mm after 6 months of functional loading and 2.05 mm after 12 months. Bone resorption was slightly higher in the mandible than in the maxilla.

Conclusions: Immediate implant loading protocol might be an attractive solution for fixed fullarch restoration using short-diameter one-stage basal implants, but long-term effects require further investigations.
Anemia and Iron Deficiency in Heart Failure — Clinical Update
Authors: Mester András , Mitre Adriana , Lázár Erzsébet , Benedek István , Kéri Johanna , Pakucs Annamária , Benedek István 
Published: March 2018

AbstractIron deficiency and anemia affect approximately half of the chronic heart failure patients and they are associated with increased hospitalization rate, lower functional capacity, lower quality of life, and higher mortality. The exact mechanism of iron deficiency in heart failure patients is still not fully understood. Current guidelines recommend ferritin as the most accurate serum biomarker for the diagnosis of iron deficiency. The use of erythropoiesis-stimulating agents is no longer recommended because of the lack of improvement on mortality or hospital readmission rate, and it was associated with a higher rate of thromboembolic events. Intravenous iron replacement therapy is safe and generally well tolerated, with fewer side effects compared to oral administration. Large randomized studies with ferric carboxymaltose demonstrated its effectiveness and superiority to oral administration, and it was associated with a decreased rate of hospitalization rate and worsening heart failure, and improvement of functional capacity and quality of life. Intravenous iron supplementation for chronic heart failure is strongly recommended by European guidelines. Further studies are needed for a better knowledge of this complex pathology and determination of the long-term safety and effectiveness of iron administration in chronic heart failure patients. .
On the topographic bias and density distribution in modelling the geoid and orthometric heights
Authors: Sjöberg Lars E. 
Published: March 2018

Abstract
It is well known that the success in precise determinations of the gravimetric geoid height (N) and the orthometric height (H) rely on the knowledge of the topographic mass distribution. We show that the residual topographic bias due to an imprecise information on the topographic density is practically the same for N and H, but with opposite signs. This result is demonstrated both for the Helmert orthometric height and for a more precise orthometric height derived by analytical continuation of the external geopotential to the geoid. This result leads to the conclusion that precise gravimetric geoid heights cannot be validated by GNSS-levelling geoid heights in mountainous regions for the errors caused by the incorrect modelling of the topographic mass distribution, because this uncertainty is hidden in the difference between the two geoid estimators.
Investigation of dielectric properties of heterostructures based on ZnO structures
Authors: Selçuk A.H. , Orhan E. , Ocak S. Bilge , Selçuk A.B. , Gökmen U. 
Published: March 2018

Abstract
The voltage and frequency dependence of dielectric constant є′, dielectric loss є″, electrical modulus M″, M′, loss tangent tanδ and AC electrical conductivity σAC of p-Si/ZnO/PMMA/Al, p-Si/ZnO/Al and p-Si/PMMA/Al structures have been investigated by means of experimental G-V and C-V measurements at 30 kHz, 100kHz, 500 kHz and 1 MHz in this work. While the values of є′, є″, tanδ and σAC decreased, the values of M′ and M″ increased for these structures when frequency was increased and those of p-Si/ZnO/Al and p-Si/PMMA/Al were comparable with those of p-Si/ZnO/PMMA/Al. The obtained results showed that the values of p-Si/ZnO/PMMA/Al structure were lower than the values of p-Si/ZnO/Al and p-Si/PMMA/Al.
Production, isolation and characterization of radiochemically pure 163Ho samples for the ECHo-project
Authors: Dorrer Holger , Chrysalidis Katerina , Goodacre Thomas Day , Düllmann Christoph E. , Eberhardt Klaus , Enss Christian , Gastaldo Loredana , Haas Raphael , Harding Jonathan , Hassel Clemens , Johnston Karl , Kieck Tom , Köster Ulli , Marsh Bruce , Mokry Christoph , Rothe Sebastian , Runke Jörg , Schneider Fabian , Stora Thierry , Türler Andreas , Wendt Klaus 
Published: March 2018

Abstract
Several experiments on the study of the electron neutrino mass are based on high-statistics measurements of the energy spectrum following electron capture of the radionuclide 163Ho. They rely on the availability of large, radiochemically pure samples of 163Ho. Here, we describe the production, separation, characterization, and sample production within the Electron Capture in Holmium-163 (ECHo) project. 163Ho has been produced by thermal neutron activation of enriched, prepurified 162Er targets in the high flux reactor of the Institut Laue-Langevin, Grenoble, France, in irradiations lasting up to 54 days. Irradiated targets were chemically processed by means of extraction chromatography, which allowed separating the formed Ho from the 162Er target-material and from the main byproducts 170Tm and 171Tm, which are co-produced in GBq amounts. Decontamination factors of >500 for Er and of >105 for Tm and yields of 3.6·1016 and 1.2·1018 atoms of 163Ho were obtained, corresponding to a recovery yield of 95 % of Ho in the chemical separation. The Ho-fraction was characterized by means of γ-ray spectrometry, Inductively-Coupled-Plasma Mass Spectrometry (ICP-MS), Resonance Ionization Mass Spectrometry (RIMS) and Neutron Activation Analysis (NAA). In this process, the thermal neutron capture cross section of 163Ho was measured to σHo-163 to Ho-164m= (23±3) b and σHo-163 to Ho-164g= (156±9) b for the formation of the two isomers of 164Ho. Specific samples were produced for further purification by mass separation to isolate 163Ho from the Ho-isotope mixture, as needed for obtaining the energy spectrum within ECHo. The partial efficiency for this second separation step is (32±5) %.
Simulationsmodelle zur ex ante Evaluation von Steuerreformen
Authors: Peichl Andreas 
Published: March 2018

Abstract
Microsimulation models (MSM) and Computable General Equilibrium models (CGE) have both been widely used in policy analysis. The combination of these two model types allows the utilization of the advantages of both types. The aim of this paper is to describe the state-of-the-art in simulation modeling and to demonstrate the benefits of linking both model types modeling using a flat tax reform proposal for Germany
Distinction of Structural Isomers of Benzenediamin and Difluorobenzene by Means of Chirped Femtosecond Laser Ionization Mass Spectrometry
Authors: Reusch Nicola , Krein Viola , Wollscheid Nikolaus , Weitzel Karl-Michael 
Published: March 2018

Abstract
Structural isomers of disubstituted benzenes are difficult to distinguish with most mass spectrometric methods. Consequently, conventional concepts for the distinction of isomers are based on coupling mass spectrometry with a chromatographic method. As an alternative approach, we propose the combination of femtosecond laser ionization with time-of-flight mass spectrometry (fs-LIMS). The possibility of systematic tailoring of fs-laser pulse shapes opens access to a multidimensional analytical technique capable of distinguishing structural isomers of the title molecules.
Our obsession with normal values
Authors: Flachskampf Frank A. , Nihoyannopoulos Petros 
Published: March 2018

Abstract
Normal values provide the background for interpretation of quantitative imaging data and thus are essential information for daily routine. Nevertheless, the ways how normal values are obtained, presented and interpreted, often do not receive the attention they deserve. We review the concepts of normalcy, the implications of typical normal ranges including the types of distribution of normal data, the possibilities to index for confounding biological factors like body surface area and the limitations of the very concept of normal values, demonstrating that there are no easy statistical solutions for difficult clinical problems.
Parental Adverse Childhood Experiences and Resilience on Coping After Discharge
Authors: Shah Anita N. , Beck Andrew F. , Sucharew Heidi J. , Litman Stacey , Pfefferman Cory , Haney Julianne , Shah Samir S. , Simmons Jeffrey M. , Auger Katherine A. ,   on behalf of the H2O Study Group
Published: March 2018

BACKGROUND AND OBJECTIVES:
Adults with a history of adverse childhood experiences (ACEs) (eg, abuse) have suboptimal health outcomes. Resilience may blunt this effect. The effect of parental ACEs (and resilience) on coping with challenges involving their children (eg, hospitalization) is unclear. We sought to quantify ACE and resilience scores for parents of hospitalized children and evaluate their associations to parental coping after discharge.

METHODS:
We conducted a prospective cohort study at a children’s hospital (August 2015–May 2016). Eligible participants were English-speaking parents of children hospitalized on the Hospital Medicine or Complex Services team. The ACE questionnaire measured the responding parent’s past adversity (ACE range: 0–10; ≥4 ACEs = high adversity). The Brief Resilience Scale (BRS) was used to measure their resilience (range: 1–5; higher is better). The primary outcome was measured by using the Post-Discharge Coping Difficulty Scale via a phone call 14 days post-discharge (range: 0–100; higher is worse). Associations were assessed by using multivariable linear regression, adjusting for parent- and patient-level covariates.

RESULTS:
A total of 671 (81% of eligible parents) responded. Respondents were primarily women (90%), employed (66%), and had at least a high school degree (65%); 60% of children were white, 54% were publicly insured. Sixty-four percent of parents reported ≥1 ACE; 19% had ≥4 ACEs. The mean Brief Resilience Scale score for parents was 3.95. In adjusted analyses, higher ACEs and lower resilience were significantly associated with more difficulty coping after discharge.

CONCLUSIONS:
More parental adversity and less resilience are associated with parental coping difficulties after discharge, representing potentially important levers for transition-focused interventions.
Nimbusz és identitás. Az IPARTERV tevékenységének recepciója a korai Kádár-korszakban
Authors: Haba Péter 
Published: March 2018

The imposition of socialist realism caused great loss of prestige and intellectual confusion in Hungarian architecture. After 1956, in the first years of the Kádár era it was preoccupied by a sort of “self-rehabilitation” and by the related aim of reviving Hungarian modernism. In this period of search the new architectural phenomena in industrial investments attracting the attention of designers and architecture theoreticians active in other areas of architecture assumed special significance.
Under the industrializing programs central to the party propaganda, there was clear-cut political intention for a long time to build materially and technically good-quality, well-designed, monumental industrial building complexes. Architectural creativity received a great boost from the efforts to create structural systems in view of the western engineering innovations and tendencies of form, adapted flexibly to the specificities of the industrializing program launched in the late 1950s, to the new technological systems and the transforming conditions of the building industry and economy.
It is not accidental therefore that a certain nimbus evolved soon around the central institution of the field, the Industrial Building Design Company (IPARTERV): the company gradually became a special creative workshop, and industrial architectural planning became a booming branch of the economy. The reception of the IPARTERV activity in the early Kádár era was dominated by the emergence of this nimbus. The aim of the paper is to explore the decisive architectural and engineering approaches, personal and collective planning roles, architectural theoretical tendencies and political factors that shaped the specific role of this company.
Dávid és Jónátán
Authors: Szilárdfy Zoltán 
Published: March 2018

The friendship of David and Jonathan is known from the Books of Samuel in the Old Testament. The presentation of the robe, the sword, the bow and the belt is the token of covenant. David’s death lament, an elegy over Jonathan’s bow given to him was called the bow song. Gottfried Bernhard Göz, a painter and graphic artist of Moravian origin working in Augsburg captured the story in an engraving with dotting. His rococo compositions were models for several painters. The oil painting in the diocesan museum of Székesfehérvár was probably made in Göz’s workshop.
The same theme features on the obverse of a 17th century silver coin recently included in the author’s collection. (The German legend reads ICH WILL DIR THUN WAS DEIN HERZ BEGEHRT – SAM. 20. V. 4) The reverse of the medal also expresses fraternity through the figures of Abraham and Lot (inscribed: WIR SIND GEBRUDER – Gen. 13. v. 8.) with well-to-do shepherds and their livestock in the background.
The art of Göz, his excellent knowledge of the Holy Writ and its use in allegories of vitues help us better interpret the baroque iconography.