bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Ultra High-DensityArabidopsis thalianaCrossover Map That Refines the Influences of Structural Variation and Epigenetic Features
Authors: Rowan Beth A , Heavens Darren , Feuerborn Tatiana R , Tock Andrew J , Henderson Ian R , Weigel Detlef 
Published: September 2019

AbstractRowan et al. generated a dataset of over 17,000 meiotic crossovers (COs) from over 2000 F2 individuals from a single Arabidopsis thaliana cross. The unprecedented density of COs and the high-quality reference genomes of the two...Many environmental, genetic, and epigenetic factors are known to affect the frequency and positioning of meiotic crossovers (COs). Suppression of COs by large, cytologically visible inversions and translocations has long been recognized, but relatively little is known about how smaller structural variants (SVs) affect COs. To examine fine-scale determinants of the CO landscape, including SVs, we used a rapid, cost-effective method for high-throughput sequencing to generate a precise map of &gt;17,000 COs between the Col-0 and Ler-0 accessions of Arabidopsis thaliana. COs were generally suppressed in regions with SVs, but this effect did not depend on the size of the variant region, and was only marginally affected by the variant type. CO suppression did not extend far beyond the SV borders and CO rates were slightly elevated in the flanking regions. Disease resistance gene clusters, which often exist as SVs, exhibited high CO rates at some loci, but there was a tendency toward depressed CO rates at loci where large structural differences exist between the two parents. Our high-density map also revealed in fine detail how CO positioning relates to genetic (DNA motifs) and epigenetic (chromatin structure) features of the genome. We conclude that suppression of COs occurs over a narrow region spanning large- and small-scale SVs, representing an influence on the CO landscape in addition to sequence and epigenetic variation along chromosomes.
Las huellas de Heidegger en La condición humana. Una disputa soterrada en torno de la praxis aristotélica
Authors: Di Pego Anabella 
Published: September 2019

El artículo muestra que La condición humana de Hannah Arendt puede leerse como una disputa soterrada con Martin Heidegger en torno de la praxis aristotélica. Por una parte, se reconstruyen las huellas de la lectura heideggeriana de Aristóteles en la obra de Arendt, para esclarecer esta presencia invisibilizada en la que se cifra uno de los puntos nodales de discusión con quien fuera su maestro. Por otra, se analiza la reconceptualización de la praxis que Arendt lleva a cabo, lo que supone una crítica a la interpretación de Heidegger y el despliegue de un marco conceptual propio que va más allá de la perspectiva aristotélica.
Multigeneration solution-processed method for silver nanotriangles exhibiting narrow linewidth (∼170 nm) absorption in near-infrared
Authors: Walia Anmol , Kumar Sandeep , Ramachandran Abhishek , Sharma Asmita , Deol Rajinder , Jabbour Ghassan E. , Shankar Ravi , Singh Madhusudan 
Published: September 2019

Abstract
Mesoporous double-perovskite LaAMnNiO6 (A = La, Pr, Sm) photothermal synergistic degradation of gaseous toluene
Authors: Tang Yiran , Tao Yuwei , Wang Qing , Zhu Zerui , Zhang Wanqi , Li Xiang , Xie Aijuan , Luo Shiping 
Published: September 2019

Abstract
Criminal Insanity, Psychosis and Impaired Reality Testing in Norwegian Law
Authors: Gröning Linda , Haukvik Unn Kristin , Melle Karl Heinrik 
Published: September 2019

How mental disorder relates to criminal insanity is a contested matter. Norway has a tradition of using a ‘medical model’ for the definition of criminal insanity that is unique in an international perspective. According to this model, insanity is determined only in relation to a medical criterion, so that all that is required is the presence of a qualifying mental disorder. Criminal insanity is, under the current rule, equated with psychosis, although this rule has recently been subject to a law reform.
This article explains and discusses this medical model by gathering together legal, forensic, and clinical empirical perspectives on the legal meaning and relevance of psychosis. The article will provide an explanation of the background of the medical model in Norwegian law, and the justifications for tying criminal insanity to psychosis. It will also explain how criminal insanity is operationalised in forensic practice, and discuss the legal conceptualisation of psychosis from a medical perspective. A main conclusion is that the legal meaning of psychosis is unclear, and the authors describe several challenges in legal and forensic practice. The authors emphasise the need for further knowledge development in the intersection between law and medicine.
The Insanity Defence: How Do We Handle Doubt?
Authors: Rosenqvist Randi 
Published: September 2019

This paper discusses how the legal definition of criminal insanity has been altered several times in the Norwegian criminal law, most recently in June 2019. There are difficulties in communicating between psychiatric experts, legal experts, and lay judges, since the description and understanding of psychotic cognition as well as the definition of legal terms are not equally understood.
Not all insanity cases are clear-cut. The Norwegian forensic experts must not conclude that the charged person is considered ‘psychotic’ in the legal sense if they are not clinically sure of this. The courts, on the other hand, must not conclude that a person is ‘sane’ if there is doubt about this. This paper discusses how there is little practical knowledge of how experts and courts handle such doubts, and highlights the lack of discussion of these questions in the legal sources.
Pengaruh Lama Autoclave Terhadap Kualitas Kimia Wheat Pollard Yang Berpotensi Sebagai Prebiotik
Authors: Utama Cahya Setya , Zuprizal Zuprizal Zuprizal , Hanim Chusnul , Wihandoyo Wihandoyo 
Published: September 2019

Penelitian bertujuan mengkaji pengaruh lama pemanasan wheat pollard dengan autoclave untuk mendapatkan monomer-monomer yang berpotensi sebagai prebiotik. Penelitian menggunakan rancangan acak lengkap pola searah dengan 4 perlakuan dan 4 ulangan. Parameter yang diamati adalah kadar air, abu, lemak kasar, protein kasar, serat kasar dan bahan ekstrak tanpa nitrogen (BETN), acid detergent fibre (ADF), neutral detergent fibre (NDF), selulosa, hemiselulosa, lignin, gross energi, mannosa, arabinosa, glukosa, sukrosa, rafinosa, amilosa, amilum, amilopektin, resisten starch dan profil wheat pollard melalui scanning electron microscope (SEM). Hasil penelitian menunjukkan bahwa terdapat pengaruh perlakuan (p<0.05) terhadap kadar air, abu, protein kasar, serat kasar, BETN, NDF, hemiselulosa, lignin, selulosa, gros energi, rafinosa, glukosa, arabinosa, sukrosa, amilosa, amilum, amilopektin, resistan starch namun pada lemak kasar, ADF dan manosa tidak berpengaruh nyata (p>0.05). Indikator wheat pollard sebagai prebiotik terlihat dari peningkatan kadar rafinosa, arabinosa dan resistan starch berturut-turut sebesar 0.72% menjadi 3.95%; 0.51% menjadi 1.04%; 0.51% menjadi 1.04% dan 5.28% menjadi 14.15%. Kesimpulan penelitian adalah wheat pollard yang diautoclave selama 15 menit memberikan komposisi terbaik sebagai prebiotik.The objective of this study was to examine the long-term effect of warming wheat pollard by autoclave to obtain potentially prebiotic monomers. The study used a completely randomized design pattern in the same direction with 4 treatments and 4 replications. The parameters observed were water content, ash, crude fat, crude protein, crude fiber, extract without nitrogen, acid detergent fiber (ADF), neutral detergent fiber (NDF), cellulose, hemicellulose, lignin, gross energy, mannosa, arabinose, glucose, sucrose, raffinose, amylose, starch, amylopectin, resistance starch and wheat pollard profile through scanning electron microscope (SEM). The results showed that there was a treatment effect (p <0.05) on moisture, ash, crude protein, crude fiber, BETN, NDF, hemicellulose, lignin, cellulose, gros energy, raffinose, glucose, arabinose, sucrose, amylose, starch, amylopectin , resistance starch but in crude fat, ADF and mannose did not have a significant effect (p>0.05). The indicator of wheat pollard as a prebiotic is seen from an increase in raffinose, arabinose and resistance starch levels of 0.72% to 3.95%; 0.51% to 1.04%; 0.51% to 1.04% and 5.28% to 14.15%. The conclusion of the study was that wheat pollard which was autoclaved for 15 minutes gave the best composition as a prebiotic.
Zoledronic acid improves bone mineral density in β-thalassemia patients with osteoporosis: a case control study
Authors: EVRAN OLGUN Mehtap , GÜRKAN Emel , TULİ Abdullah 
Published: September 2019

Purpose: This study addresses the efficacy of zoledronic acid treatment in osteoporotic patients with β-thalassemia.Materials and Methods: Thirty-nine thalassemic patients were enrolled in this study. Bone mineral density was measured using Dual energy x-ray absorbtiometry (DEXA), and biochemical markers of osteoporosis in serum and urine were measured at 0, 6, and 12 months of treatment. Patients with thalassemia were randomly received either zoledronic acid 4 mg IV once every six months or calcitriol 0.25 mcg / day for 12 months. A subgroup analysis was also performed according to gonadal status. Results: There were 21 males and 18 females, mean age of 23.1 ± 1.3 and bone age of 16.3±0.35 years. At the end of 12 months, bone mineral densities of the lumbar vertebra and femoral neck significantly increased in the zoledronic acid group. In patients with hypogonadism who received hormone replacement therapy, t-scores significantly increased. Serum NTX levels indicated significant increase in both treatment groups compared with the control group at the end of the treatment. A significant increase was obtained in urinary NTX level in hypogonadal patients who received zoledronic acid, and in serum NTX and IGF-1 levels in normogonadal patients who received calcitriol. Conclusion: In our study, zoledronic acid resulted in significant improvement in bone mineral density and t-scores. This improvement was in correlation with IGF-1 levels.
Ankle isokinetic muscle strength and navicular drop in athletes with medial tibial stress syndrome
Authors: ERCAN Sabriye 
Published: September 2019

Purpose: The purpose of this study is to compare some anatomical features and ankle isokinetic muscle strength of adolescent athletes with medial tibial stress syndrome (MTSS) and healthy control group and to examine the adequacy of ‘tibial facial traction theory in the development of MTSS.Materials and Methods: Adolescent athletes who had been diagnosed with MTSS during the season and healthy control group participants were included in the study. Demographic data and training details of the athletes were recorded. The MTSS score was used to determine the severity of the injury. The navicular drop test, lower extremity length measurement, and isokinetic muscle strength measurement were performed. Results: The complaint duration of the patients with MTSS (n:21) was 1.8 ± 1.8 months and the MTSS score was 3.9 ± 2.2. The control group (n:12) and the athletes diagnosed with MTSS had similar demographic characteristics and training details. There was no difference between the groups in terms of navicular drop and lower extremity length. There was no ‘lower extremity difference’ for right and left extremities. According to the results of the isokinetic muscle strength test in plantarflexion and dorsiflexion direction, there was no difference between the groups in terms of muscle strength at both low and high angular speeds. Conclusion: ‘The tibial traction theory’ does not sufficiently explain the pathogenesis of MTSS. Studies which evaluate isokinetic muscle strength and perform real-time dynamic analysis on the track are required to make recommendations for ideal protection and rehabilitation in cases of MTSS.
Serum apelin-36 levels in pre-diabetics and newly diagnosed diabetes mellitus patients
Authors: YALÇINKAYA KARA Zeynep Mine , SERİN Erdinç , DAĞ İsmail , SERİN Özden 
Published: September 2019

Purpose: The aim of this study was to investigate the levels of parameters for glucose metabolism and cardiovascular risk factors and apelin-36 in patients grouped as having impaired fasting glucose(IFG), IFG and impaired glucose tolerance(IGT), newly diagnosed type 2 DM and the control group.Materials and Methods: Fifty-three women and twenty-seven men, totally eighty subjects were enrolled in this study. The patients were classified into four groups according to their oral glucose tolerance test (OGTT) results. Group1: Normoglycemic controls(n:20), Group2: subjects with IFG(n:20), Group3: combined IFG subjects which included both IFG and IGT patients(n:20), Group4: Newly diagnosed type 2 DM patients(n:20). Levels of glucose, lipids, HbA1c, fibrinogen, insulin, cortisol, serum apelin-36 and C-peptide were analyzed.Results: There was a statistically significant difference regarding the levels of apelin-36 between group 1 and the study groups 2, 3 and 4, respectively. Other parameters analyzed for glucose metabolism and cardiovascular risk factors such as fasting glucose, HbA1c, HOMA-IR, fibrinogen, insulin, cortisol, C-peptide, LDL-cholesterol, HDL-cholesterol, VLDL-cholesterol, triglycerides, total cholesterol were significantly higher in the study groups when compared to the control group.Conclusion: In the future serum apelin-36 levels can be used as an indicator for presenting the insulin resistance and impairment in glucose metabolism in the early periods.
Comparison of objective and subjective voice change parameters after medical treatments in allergic rhinitis
Authors: ERKAN Sanem Okşan , TUHANİOĞLU Birgül , ÖZDAŞ Talih , ERKAN Zeynel Abidin , TÜZÜN Kemal , ÖZDEN Güzin , ŞENKAL Özgül Akın 
Published: September 2019

Purpose: In the present study, we aimed to investigate the efficacy of different treatments on voice quality in allergic rhinitis. Thus we compared the objective and subjective voice parameters of patients with allergic rhinitis before and after treatment groups. Materials and Methods: Patiens treated with intranasal steroid sprey is the 1. group, intranasal steroid spray+oral antihistamine is the 2. group. The objective ( fundamental frequency(F0) ,shimmer%, jitter%, noise to harmonics ratio (NHR) and subjective (total nasal symptom score(TNSS), voice-handicap index(VHI ) ) voice analysis were compared .Results: All voice parameters were improved after treatment in both groups except F0 in group 1. F0 values after treatment in the 2. group was significantly higher than before treatment; F0 values in the 1. group was higher but it was insignificant. There was no significant difference between the subjective parameters and objective parameters including F0, jitter%, shimmer% and NHR values between group 1 and group 2. Conclusion: We found that voice quality improved with intranasal steroid sprey treatment, and also with the addition of oral antihistamine to intranasal steroid in allergic rhinitis. However, no significant difference was detected in voice analysis with this combined treatment in the subjective and objective evaluation .
İnsan parechoviruslarının özellikleri, epidemiyolojisi ve klinik önemi
Authors: TOKAK Semih , ÖZDEMİR Mehmet 
Published: September 2019

İnsan Parechoviruslar (Human Parechovirus; HPeV) tek iplikli, pozitif polariteli RNA viruslarıdır. Başlangıçta klinik ve morfolojik özelliklerine göre insan enterovirusları içerisinde Echovirus 22 ve 23 olarak tanımlansalar da, genom organizasyonu, yapı ve replikasyonlarında birkaç farklı özellikleriyle enteroviruslar ve diğer picornavirus gruplarından farklı oldukları gösterilmiştir. HPeV’ler genetik ve antijenik heterojenlik göstermekte ve birçok tipi dünyanın her yerinde bulunan insan popülasyonunda yaygın bir şekilde bulunmaktadır. HPeV1 en yaygın genotip olup sıklıkla gastrointestinal ve solunum yolu hastalıklarına neden olmaktadır. HPeV3 enfeksiyonu yenidoğanlarda ve 3 aydan daha küçük infantlarda sepsis, meningoensefalit, nörolojik sekellere ve ölümlere yol açmaktadır. Küçük infantlarda tipik klinik tablo, ateş, şiddetli sinirlilik ve kızarıklıktan oluşur ve sıklıkla “ateşli, kırmızı döküntülü, kızgın bebekler” tanımına sebep olmaktadır. Günümüzde HPeV’lerin tanısı için en duyarlı metod real-time polimeraz zincir reaksiyonudur. Enfeksiyonlarının tedavisinde şimdiye kadar kadar herhangi bir spesifik antiviral tedavi mevcut olmayıp monoklonal antikorların kullanımı değerlendirilmektedir. HPeV’ler üzerine yapılacak daha fazla çalışma ile bu virusların spesifik karakteristiklerinin anlaşılmasına ve uygun tedavi stratejilerinin geliştirilmesine ihtiyaç vardır.
Using Ethnographic Methods to Explore How International Business Students Approach Their Academic Assignments and Their Experiences of the Spaces They Use for Studying
Authors: Jensen Kathrine S. H. , Ramsden Bryony , Haigh Jess , Sharman Alison 
Published: September 2019

Abstract
Objective – Understanding students’ approaches to studying and their experiences of library spaces and other learning spaces are central to developing library spaces, policies, resources and support services that fit with and meet students’ evolving needs. The aim of the research was to explore how international students approach academic assignments and how they experience the spaces they use for studying to determine what constituted enablers or barriers to study. The paper focuses on how the two ethnographic methods of retrospective interviewing and cognitive mapping produce rich qualitative data that puts the students’ lived experience at the centre and allows us a better understanding of where study practices and study spaces fit into their lives.
Methods – The study used a qualitative ethnographic approach for data collection which took place in April 2016. We used two innovative interview activities, the retrospective process interview and a cognitive mapping activity, to elicit student practices in relation to how they approach an assignment and which spaces they use for study. We conducted eight interviews with international students in the Business School, produced interview notes with transcribed excerpts, and developed a themed coding frame.
Results – The retrospective process interview offered a way of gathering detailed information about the resources students draw on when working on academic assignments, including library provided resources and personal social networks. The cognitive mapping activity enabled us to develop a better understanding of where students go to study and what they find enabling or disruptive about different types of spaces. The combination of the two methods gave students the opportunity to discuss how their study practices changed over time and provided insight into their student journeys, both in how their requirements for and knowledge of spaces, and their use of resources, were evolving.
Conclusion – The study shows how ethnographic methods can be used to develop a greater understanding of study practices inside and outside library spaces, how students use and feel about library spaces, and where the library fits into the students’ lives and journey. This can be beneficial for universities and other institutions, and their stakeholders, looking to make significant changes to library buildings and/or campus environments.
Quality of Life of Kurdish Women from Martyrs’ Families in Kurdistan Region of Iraq as a Middle East Conflict Area
Authors: Ahmed Hamdia Mirkhan 
Published: September 2019

Abstract
Background

Quality of life (QOL) research develops data and insight into issues that pertain not only to the individual but also can apply to the population as a whole. This study aimed to analyze the QOL of Kurdish women from martyr families of Kurdistan region of Iraq.Methods

A cross sectional study was conducted on 380 women from martyrs’ families who were patients at the Medical Center of Martyr Families in Erbil City during the period of January 2018 to April 2019. Through direct interviews data were collected and the WHOQOL-BREF scale was used for measuring the QOL. The samples were divided into four categories (quartiles) according their QOL score: 1st, 2nd, 3rd and 4th quartile. Kruskal-Wallis and Chi-Square tests were used for data Analysis.Results

The QOL domains of the study sample were set in following quartiles: Overall QOL and General Health Domain (66.6%) and Physical and Psychological Health Domain (56.9%) in 1st and 2nd quartiles, Social Relationships (47.9%) in 3rd quartile, Environment Domain (85.6%) in 2nd and 3rd quartile. The total QOL of more than half (52.1%) of the studied women were in 1st and 2nd quartiles.Conclusion

Women of martyr families were not satisfied with their QOL especially in Physical and Psychological Domains. International political and humanitarian actions are needed to reduce the destructive consequences of war and conflicts on these suffering women.
Primary surgery versus no surgery in synchronous metastatic breast cancer: Patient-reported Quality-of-Life outcomes of the prospective randomized multicenter ABCSG-28 Posytive Trial
Authors: Bjelic-Radisic Vesna , Fitzal Florian , Knauer Michael , Steger Guenther , Egle Daniel , Greil Richard , Schrenk Peter , Balic Marija , Singer Christian , Exner Ruth , Soelkner Lidija , Gnant Michael 
Published: September 2019

Abstract
Background: The ABCSG-28 trial compared primary surgery followed by systemic therapy versus primary systemic therapy without surgery in patients with de novo stage IV BC. The present report describes QoL results of this trial. Methods: 90 patients with primary operable MBC were randomised to surgery of the primary tumor followed by systemic therapy or to primary systemic therapy without surgery. QoL analyses covering the results at baseline, 6,12,18 and 24 months follow up of 79 (88%) patients, was assessed with the EORTC QLQ-C30 and QLQ-BR23 questionnaires. Results: There were no statistically significant differences in any of the scales of the QLQ-C30 and QLQ-BR23 questionnaires between the two groups over the time. Baseline global health status and physical functioning were predictors for OS (patients with a higher score lived longer (p=0.0250, p=0.0225; p=0.0355, p=0.0355)). Global health status, social functioning scale, breast symptoms and future perspective were predictors for longer TTPd (p=0.0244; p=0.0140, p=0.020; p=0.0438, p=0.0123). Patients in both arms reported significant improvement on the emotional functioning scale. Cognitive functioning decreased over time in both groups. Younger women had clinically relevant better physical and sexual functioning scores (p=0.039 and 0.024). Conclusion: Primary surgery does not improve nor alter QoL of patients with de novo stage IV BC. Global health status and physical functioning were predictors for OS and could be use as additional marker for prediction of OS and TTTd in patients with de novo stage IV BC.