bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of listening to the voice recording of relatives on chest pain, anxiety and depression in patients hospitalized in the coronary intensive care unit: A randomized controlled trial
Authors: Uğurlu Yasemin Kalkan , Alemdar Dilek Küçük 
Published: October 2024

AbstractBackgroundAfter acute myocardial infarction, the prevalence of anxiety and depression is quite high in patients because of severe chest pain, distance from relatives, unfamiliar environment and orientation problems.AimTo assess the effect of listening to the voice recordings of relatives of patients with acute myocardial infarction who were treated in the coronary intensive care unit (ICU) on chest pain, anxiety and depression parameters of the patients.MethodsIn the study, which was conducted as a randomized controlled trial, voice recordings of the family members of the patients were created and played to the patients through a music pillow. The study was carried out with 60 patients, 30 experimental and 30 control groups. Three tests were applied to the patients 15 min before, and 15 and 30 min after the application. The data of the study were collected using the Patient Introduction Form, Hospital Anxiety Depression Scale, Visual Analogue Scale and Patient Follow‐up Form.ResultsIt was found that there was a significant decrease in the anxiety level of the patients in the intervention group after listening to the audio recording (p < .001, 95% CI: −3.796; −0.070). However, there was no significant difference between the pain and depression scores of the control and intervention groups (p > .05).ConclusionsIn the ICUs of patients with acute myocardial infarction, it may be recommended to play audio recordings of their relatives to reduce the severity of anxiety.Relevance to Clinical PracticeIn the intensive care setting, the use of voice recordings of relatives can be used as an effective, non‐pharmacological intervention to reduce anxiety in patients with acute myocardial infarction. This approach may potentially improve overall recovery by reducing patient anxiety in the intensive care setting.
Linking seedling wood anatomical trade‐offs with drought and seedling growth and survival in tropical dry forests
Authors: González‐Melo Andrés , Salgado‐Negret Beatriz , Norden Natalia , González‐M Roy , Benavides Juan Pablo , Cely Juan Manuel , Abad Ferrer Julio , Idárraga Álvaro , Moreno Esteban , Pizano Camila , Puentes‐Marín Juliana , Pulido Nancy , Rivera Katherine , Rojas‐Bautista Felipe , Solorzano Juan Felipe , Umaña María Natalia 
Published: October 2024

Summary
Wood anatomy plays a key role in plants' ability to persist under drought and should therefore predict demography. Plants balance their resource allocation among wood cell types responsible for different functions. However, it remains unclear how these anatomical trade‐offs vary with water availability, and the extent to which they influence demographic rates.
We investigated how wood anatomical trade‐offs were related to drought and demographic rates, for seedling communities in four tropical dry forests differing in their aridity indexes (AIs). We measured wood density, as well as vessel, fiber and parenchyma traits of 65 species, and we monitored growth and survival for a 1‐yr period.
Two axes defined wood anatomical structure: a fiber‐parenchyma axis and a vessel‐wood density axis. Seedlings in drier sites had larger fiber but lower parenchyma fractions, while in less dry forests, seedlings had the opposite allocation pattern. The fiber–parenchyma trade‐off was unrelated to growth but was positively related to survival, and this later relationship was mediated by the AI.
These findings expand our knowledge about the wood anatomical trade‐offs that mediate responses to drought conditions and influence demographic rates, in the seedling layer. This information is needed to anticipate future responses of forests to changing drought conditions.
Virtual reality–based music attention training for acquired brain injury: A randomized crossover study
Authors: Jeong Eunju , Ham Yeajin , Lee Su Jeong , Shin Joon‐Ho 
Published: October 2024

AbstractThis single‐blind randomized crossover study aimed to explore the effectiveness of virtual reality–based music attention training (VR‐MAT) on cognitive function and examine its potential as a cognitive assessment tool in people with acquired brain injury (ABI). Overall, 24 participants with cognitive impairment secondary to a first‐ever ABI underwent VR‐MAT and conventional cognitive training (CCT) 3 months after onset. This was performed in two 4‐week phases, over 8 weeks. During VR‐MAT, participants engaged in attention training through a four‐level virtual drumming program designed to enhance various attentional aspects. In contrast, during CCT, participants underwent structured conventional training, including card sorting and computerized training. Neuropsychological evaluations were performed preintervention, during the fourth and eighth weeks, and post‐intervention using tests to evaluate attention and executive function, along with global neuropsychological assessments. In the VR‐MAT group, significant differences were observed between pre‐ and post‐intervention in the trail making test‐black and white version B (p = 0.009) and version B–A (p = 0.018) and clinical dementia rating‐sum of boxes (p = 0.035). In the CCT group, significant differences were observed in spatial working memory (p = 0.005) and the mini‐mental state examination scores (p = 0.003). VR‐MAT is an effective cognitive intervention that is particularly beneficial for improving attention in people with ABI.
The Critical Roles of Phosphatidylethanolamine‐Binding Proteins in Legumes
Authors: Su Tong , Wu Yichun , Fang Chao , Liu Baohui , Lu Sijia , Kong Fanjiang , Liu Huan 
Published: October 2024

ABSTRACTLegumes, characterized by their ability to form symbiotic relationships with nitrogen‐fixing bacteria, play crucial roles in agriculture, ecology and human nutrition. Phosphatidylethanolamine‐binding proteins (PEBPs) are the key genetic players that contribute to the diverse biological functions of legumes. In this review, we summarize the current understanding of important roles of PEBP genes in legumes, including flowering, inflorescence architecture, seed development and nodulation. We also delve into PEBP regulatory mechanisms and effects on plant growth, development, and adaptation to the environment. Furthermore, we highlight their potential biotechnological applications for crop improvement and promoting sustainable agriculture. This review emphasizes the multifaceted roles of PEBP genes, shedding light on their significance in legume biology and their potential for sustainable productive farming.
Immunomodulatory effect of mesenchymal stem cells‐derived extracellular vesicles to modulate the regulatory T cells and Th1/Th2 imbalance in peripheral blood mononuclear cells of patients with allergic rhinitis
Authors: Wang Zhao , Shahzad Khawar Ali , Li Xuran , Cai Boyu , Xu Maoxiang , Li Jiaojiao , Tan Fei 
Published: October 2024

AbstractMesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) have shown promising immunomodulatory capabilities for a variety of clinical conditions. However, the potential regulatory mechanisms of MSC‐EVs in allergic rhinitis (AR) remain unexplored. The present study was designed to investigate the immunomodulatory effect of MSC‐EVs in patients with AR. Peripheral blood mononuclear cells (PBMCs) were isolated from AR patients. The number of peripheral CD4+Foxp3+IL‐17+, CD4+Foxp3+IL‐17− and CD4+Foxp3−IL‐17+ T cells in healthy controls and AR patients were evaluated using flow cytometry. Therapeutic effect of MSC‐EVs was determined by detecting IFN‐γ, IL‐4, IL‐17 and IL‐10 cytokines in supernatant by ELISA and flow cytometry. The mean fluorescence intensity (MFI) was calculated in PBMCs for IL‐10, IL‐17 and TGF‐β on T cells after MSC‐EVs treatment. Bioinformatic analysis of microRNA was performed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. CD4+Foxp3+IL‐17+ T cells expression in PBMCs was higher in the AR group and the balance of Treg/Th17 was tilted towards Th17 cells. Supernatant from AR patients revealed that MSC‐EVs treatment upregulated IL‐10 and IFN‐γ, and downregulated IL‐4 and IL‐17. EVs treatment effectively re‐established Th1(CD4+IFN‐γ+cells)/Th2(CD4+IL‐4+cells) balance, reduced CD4+IL‐17+ and increased CD4+IL‐10+ and CD4+TGF‐β+ cells. The MFI of IL‐10 and TGF‐β in CD4+CD25+CD127− T cells were higher, whereas lower levels of IL‐17 were observed. Bioinformatic analysis revealed that the TGF‐β, Wnt signalling pathways and STAT5 transcription factor might mechanistically support the immunomodulatory effect of MSC‐EVs. This study presents the immunomodulatory effect of MSC‐EVs in PBMCs from AR patients. The results provide a new therapeutic strategy for AR.
Lacewing‐specific Universal Single Copy Orthologs designed towards resolution of backbone phylogeny of Neuropterida
Authors: Lai Yan , Du Shiyu , Li Hongyu , Zheng Yuchen , Ardila‐Camacho Adrian , Aspöck Ulrike , Aspöck Horst , Yang Ding , Zhang Feng , Liu Xingyue 
Published: October 2024

AbstractUniversal Single Copy Orthologs (USCOs), as a set of markers of nearly universal single‐copy genes, show a superiority in phylogenomic inference. Here, we developed a Benchmarking Universal Single Copy Orthologs (BUSCOs) dataset, neuropterida_odb10, tailored for Neuropterida, based on high‐quality genome assemblies and transcriptome data, comprising 5438 BUSCOs. A range of 1524–5328 complete and single‐copy USCOs could be captured from the genome assemblies and transcriptomes of 104 species of Neuropterida. The reconstruction of a higher‐level phylogeny of Neuropterida based on a comprehensive sampling and refined genomic data in reference to neuropterida_odb10 validates the efficiency of this BUSCO dataset for phylogenomic inference. We recovered Psychopsidae as the sister group to Ithonidae, and corroborated the sister group relationship between Sisyridae and Nevrorthidae within Osmyloidea and the sister group relationship between Chrysopidae and Mantispoidea. Furthermore, our findings highlight that focusing on alignments with a higher presence of parsimony‐informative sites, rather than on the total number of alignments, can diminish errors in gene tree estimation, a process notably vulnerable to error when using multispecies coalescent methods. The neuropterida_odb10 BUSCO reference dataset holds promise for phylogenetic studies at various hierarchical levels, as well as for comparative genomics and the exploration of species diversity within Neuropterida.
Effectiveness of FIFA 11+ Injury Prevention Programs in Reducing Head and Neck Injuries, Including Concussion, Among Soccer Players: A Systematic Review and Meta-Analysis
Authors: Al Attar Wesam Saleh A. , Majrashi Ali , Bizzini Mario 
Published: October 2024

The Federation Internationale de Football Association (FIFA) 11+ and 11+ Kids injury prevention programs have shown success in reducing overall injury risk in soccer players, yet their specific impact on head and neck injuries remains inadequately explored. Purpose: To evaluate the effectiveness of FIFA 11+ and 11+ Kids injury prevention programs in reducing the incidence of head and neck injuries among soccer players. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 2 investigators independently conducted searches in databases (Cochrane Library, PubMed, Web of Science, and PEDro) using keywords like “FIFA 11+,” “football,” “soccer,” and “injury prevention.” Only randomized controlled trials assessing FIFA 11+ programs in soccer players were included. Data analysis used the random effects model with RevMan Meta-Analysis software (version 5). Results: Among 397 studies, 4 met inclusion criteria. Pooled results from 7109 players and 532,341 exposure hours indicated a significant 40% reduction in head and neck injuries per 1000 hours of exposure in the intervention group compared to the control group (injury risk ratio 0.60, 95% CI, 0.41–0.88). Conclusion: Implementing FIFA 11+ injury prevention programs significantly reduces the risk of head and neck injuries in soccer players, offering a compelling alternative to traditional warm-ups. This study contributes valuable evidence for optimizing injury prevention strategies in soccer training regimens.
Socioeconomic inequality in postnatal care utilisation among reproductive age women in sub-Saharan African countries with high maternal mortality: a decomposition analysis
Authors: Fetene Samrawit Mihret , Fentie Elsa Awoke , Shewarega Ever Siyoum , Kidie Atitegeb Abera 
Published: October 2024

ObjectiveTo assess the socioeconomic inequality in postnatal care (PNC) utilisation and its contributors among women in 14 sub-Saharan African countries with high maternal mortality.DesignCommunity-based cross-sectional study using Demographic Health SurveySettingAfrica countries with the highest maternal mortality ratio (14 countries)ParticipantsAll women who had given birth within 2 years prior to the survey (n=64 912)Primary outcomesPostnatal care utilisationResultsThe percentage of women who had PNC utilisation was lowest in Ethiopia (23.4%: 95% CI: 22.1%, 24.7%) and highest in The Gambia (91.5%: 95% CI: 90.6%, 92.4%). There was statistically significant pro-rich inequality in the PNC utilisation in all countries except Liberia, meaning PNC utilisation was disproportionately concentrated among women from wealthier households. The weighted Erreygers Normalized Concentration Index (ECI) ranged from 0.0398 in The Gambia to 0.476 in Nigeria; the second-highest inequality was in Cameroon (0.382), followed by Guinea (0.344). The decomposition analysis revealed that the wealth index was the largest contributor to inequality in PNC utilisation in seven countries: Benin, Burundi, The Gambia, Guinea, Nigeria, Sierra Leone, Tanzania. In contrast, educational status emerged as the primary contibutor in Cameroon and Zimbabwe, media exposure in Mali and Mauritania, and distance to healthcare facilities in Ethiopia. However, in Liberia, the weighted ECI of 0.0012 with a p value of 0.96 indicate that there is no significant socioeconomic inequality in PNC utilisation, suggesting that the distribution of PNC utilisation is almost equal across different socioeconomic groups.ConclusionOur study revealed a pro-rich inequality in PNC utilisation across all included sub-Saharan African countries with high maternal mortality, except Liberia. This implies that PNC utilisation disproportionately favours the wealthy. Therefore, financially better-off women are more likely to utilise PNC services compared to those who are poor. Addressing the identified contributors of socioeconomic inequalities in PNC utilisation in each country remains crucial for achieving equity in PNC utilisation.
Breadth and visibility of children’s lower limb chronic musculoskeletal pain: a scoping review
Authors: Ilhan Emre , Davies Luke , Pacey Verity , Smith Mitchell , Munro Jane , Munns Craig , Sturgiss Elizabeth , Williams Nicole , Tofts Louise , Locke Vance , Haines Terry , Brennan Sue E , Maloney Stephen , Sarkies Mitchell N , Clavisi Ornella , Miles Dan , Nissen Lisa , Williams Cylie 
Published: October 2024

ObjectiveTo identify the types of conditions reported in peer-reviewed literature that result in chronic musculoskeletal lower limb pain in children and adolescents and explore the alignment of these conditions with the chronic pain reporting codes indexed in the International Classification of Diseases 11th Revision (ICD-11).DesignThis scoping review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sourcesFive electronic databases were searched (Medline, EMBASE, PsycINFO, CINAHL and the Cochrane Library).Eligibility criteriaArticles involving children and adolescents under 18 years and reporting on chronic musculoskeletal pain of the lower limb were included.Data extraction and synthesisWe assigned an ICD-11 code to each condition based on details reported in the study. We recorded whether any of the presenting conditions were linked to an ICD-11 chronic pain manifestation code.ResultsFrom 12 343 records, 418 papers were included. There were 124 unique conditions associated with chronic lower limb pain, the most commonly reported being chronic widespread musculoskeletal pain (24 studies) and juvenile idiopathic arthritis (26 studies). Only 11.1% of presenting conditions were linked to an ICD-11 chronic pain manifestation code.ConclusionMost presenting conditions associated with chronic pain in the lower limb do not have a chronic pain manifestation code in the new global standard for recording health information. This means chronic pain associated with common lower limb conditions may remain invisible in global statistics.
High-grade cervical disease and cervical cancer in women aged 50 years and older compared with younger women: examining prevalence by HIV status in two large prospective cohorts in Botswana
Authors: Luckett Rebecca , Zhang Bessie X , Gompers Annika , George Jessica , Modest Anna , Bazzett-Matabele Lisa , Vuylsteke Peter , Kula Maduke , Monare Barati , Botha Matthys H , Shapiro Roger L , Ramogola-Masire Doreen , Grover Surbhi 
Published: October 2024

ObjectivesInternational guidelines recommend cervical screening cessation at age 50 following two consecutive negative screens. However, many women aged 50 and older in low-income and middle-income countries (LMICs) have not had prior opportunity to screen. We examine the prevalence of cervical dysplasia and cervical cancer stage in Botswana women aged 50+ compared with 30–49, stratified by HIV status.DesignSecondary analysis of data from two prospective cohort studies.SettingThe screening cohort was recruited at health facilities in South East District. The cancer cohort was recruited from the primary public tertiary referral hospital and a private hospital in Gaborone, Botswana.ParticipantsThe screening cohort included 2570 women aged 30 and older recruited from February 2021 to August 2022. Screening eligibility included anyone with a cervix and without a prior history of cervical cancer. The cancer cohort included 1520 patients diagnosed with cervical cancer who sought care at the facilities where recruitment took place from January 2015 to December 2022.Primary and secondary outcome measuresThe prevalence of cervical intraepithelial neoplasia (CIN)2+ and cancer stage at diagnosis was compared across age groups, stratified by HIV status. Prevalence ratios were calculated for the association between age and CIN2+/CIN3+via log-binomial regression.ResultsThe prevalence of CIN2+ was similar between 30–49 years old and 50+, both among women with HIV (WWH, 15.9% and 19.3%, respectively) and without HIV (13.3% and 10.4%, respectively). Similar findings were found when CIN3+ was used as the outcome. There were no statistically significant differences in prevalence ratios (PRs) across age groups for CIN2+ (adjusted PR (aPR) WWH 1.1 (95% CI 0.80 to 1.6); aPR HIV− 0.78 (95% CI 0.45 to 1.4) nor CIN3+ (aPR WWH 1.1 (95% CI 0.70 to 1.6); aPR HIV− 0.81 (95% CI 0.40 to 1.7)). Nearly half of cervical cancer diagnoses were made in women 50+; three-quarters of cases in women without HIV were diagnosed at 50+ years.ConclusionsOur findings demonstrate the prevalence of high-grade cervical dysplasia and cervical cancer remains high beyond age 50 in both women with and without HIV in an LMIC context with high HIV prevalence. Screening women 50+ will allow treatment for cervical dysplasia and may provide early diagnosis of curable cervical cancer. These findings support the rapid introduction of high-performance cervical screening to increase access for women 50+.Trial registration numberNCT04242823.
Assessing the Utility of the DAPT Score and PRECISE‐DAPT Score in Determining the Appropriateness of Dual Antiplatelet Therapy in Patients With Acute Myocardial Infarction/Percutaneous Coronary Intervention
Authors: Singh Abhishek , Hussain M. A. , Chaudhary Shyam Chand , Bharadwaj Akriti , Sawalani K. K. , Pradhan Akshyaya , Sethi Rishi 
Published: October 2024

Background: Utilizing the two available prediction models, i.e., the dual antiplatelet therapy (DAPT) score and predicting bleeding complication in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE‐DAPT) score, we aimed to determine the appropriateness of the DAPT in patients with acute myocardial infarction (AMI) in patients undergoing percutaneous coronary intervention (PCI).Methods: We retrospectively enrolled 235 patients of AMI and for all the patients and thorough information regarding history, risk factors, and medications were collected. Both DAPT and PRECISE‐DAPT scores were calculated. The patients were divided by their recommended cutoffs and the appropriateness of the duration of the recommended DAPT was measured based on the observed scores. Bleeding academic research consortium (BARC) classification was used to define the bleeding events. In the patients with DAPT score ≥ 2 and PRESICE‐DAPT < 25, the prolonged use of DAPT was recommended.Results: Overall, 235 patients, predominantly male (78.7%), with baseline characteristics exhibiting high rate of smoking (31.1%), diabetes (35.3%), and hypertension (32.8%) were found. The widely prescribed DAPT combination was aspirin with clopidogrel (72.3% at discharge and 46% on current use). Among all the enrolled patients, 163 patients were on DAPT while 71 were on single antiplatelet therapy (SAPT). A significant association between DAPT and PRECISE‐DAPT scores was noted in terms of SAPT and DAPT. The appropriateness of DAPT was checked based on the scores, where 81% of the patients with DAPT ≥ 2 and 77.24% with PRECISE‐DAPT score < 25 were appropriately prescribed with DAPT. The primary reason for drug interruptions was self‐advised. The incidence of bleeding events was observed to be 7.23%, among which 5.1% had Type 1 bleeding according to BARC.Conclusion: Both DAPT and PRECISE‐DAPT scores could be used to determine the appropriateness of the recommendations of DAPT in patients with AMI or undergoing PCI.