bluuebunny/crossref_metadata_2025_split huggingface dataset:
A conceptual framework for clinicians working with artificial intelligence and health‐assistive Smart Homes
Authors: Dermody Gordana , Fritz Roschelle 
Published: November 2018

AbstractThe Smart Home designed to extend older adults independence is emerging as a clinical solution to the growing ageing population. Nurses will and should play a key role in the development and application of Smart Home technology. Accordingly, conceptual frameworks are needed for nurse scientists who are collaborating with multidisciplinary research teams in developing an intelligent Smart Home that assists with managing older adults’ health. We present a conceptual framework that is grounded in critical realism and pragmatism, informing a unique mixed methodological approach to generating, analyzing, and contextualizing sensor data for clinician‐based machine learning. This framework can guide nurse scientists in knowledge construction as they participate in multidisciplinary health‐assistive Smart Home and artificial intelligence research. In this paper, we review philosophical underpinnings and explicate how this framework can guide nurse scientists collaborating with engineers to develop intelligent health‐assistive Smart Homes. It is critical that clinical nursing knowledge is integrated into Smart Home and artificial intelligence features. A conceptual framework and practical method will provide needed structure for knowledge construction by nurse scientists.
Hemophagocytic lymphohistiocytosis is a sign of poor outcome in pediatric Epstein‐Barr virus‐associated post‐transplant lymphoproliferative disease after allogeneic hematopoietic stem cell transplantation
Authors: Ali Salah , AlThubaiti Sami , Renzi Samuele , Krueger Joerg , Chiang KY , Naqvi Ahmed , Schechter Tal , Punnett Angela , Ali Muhammad 
Published: November 2018

AbstractEBV‐related PTLD developing after HSCT is a potentially life‐threatening disease. HLH is uncommon after allogeneic HSCT. Data on outcome of patients with PTLD and concomitant HLH after allogeneic HSCT are limited. In this retrospective study, we collected demographic, clinical, laboratory, and outcome data for 408 patients who underwent allogeneic HSCT from 2006 to 2015. Graft source included CB (n = 135; 33.1%), PBSCs (n = 34; 8.3%), and BM (n = 239; 58.6%). Eight out of 408 patients (2%) developed EBV‐PTLD with a median age at HSCT of 5.9 years (range: 2.3‐17.3). All eight patients received ATG as part of the conditioning regimen. Graft source was PBSC in three patients (37.5%), BM in four patients (50%), and CB in one patient (12.5%). Donors were matched unrelated in five patients (62.5%) and matched sibling in three patients (37.5%). Seven out of eight patients developed EBV‐PTLD within the first 100‐day post‐HSCT. Lymph node biopsy revealed early lesions in three patients, polymorphic in three patients, and monomorphic PTLD in two patients. Three patients (37.5%) died within 1 month of EBV‐PTLD diagnosis. All deceased patients developed HLH manifestations with two of them meeting HLH diagnostic criteria and one having an incomplete workup. PTLD after allogeneic HSCT with manifestations of HLH is associated with high mortality. Early identification and treatment of EBV‐PTLD seems imperative to control the disease, especially if signs of HLH are evolving.
Schistosoma haematobium cercarial infection alters subsequent systemic immune responses to eggs but has minimal impact on immune responses to egg injection of the bladder
Authors: Loc Le , Mbanefo Evaristus C. , Khludenev George , Lamanna Olivia , Banskota Nirad , Hsieh Michael H. 
Published: November 2018

SummaryAimsMouse bladder wall injection with Schistosoma haematobium eggs has been used to overcome limitations in animal models of urogenital schistosomiasis. However, the effect of the absence of cercarial infection on immune responses to eggs in this model is unknown. We hypothesized that cercarial infection would alter local bladder and systemic immune responses to eggs in this model.Methods and resultsMice were infected or not infected with S haematobium cercariae, and then, their bladder walls injected with S haematobium eggs or vehicle 5 weeks following cercarial infection. Three weeks later, mice were bled, sacrificed, perfused and their bladders harvested. Parasitological parameters and gross bladder pathology were not changed in egg‐injected bladders by cercarial exposure. Figure S1 shows no changes in either granulomas or fibrosis. The only bladder cytokine upregulated in egg‐injected bladders by cercarial exposure (vs no exposure) was leptin. Cercarial exposure, compared to no exposure, resulted in increased serum, IL‐1α, IL‐13 and TGF‐β in bladder egg‐injected mice.ConclusionCercarial exposure altered systemic responses of several cytokines in bladder egg‐injected mice, but surprisingly, only modified leptin expression in bladder tissue. This suggests that depending on the specific application, cercarial exposure may not be strictly necessary to model local immune responses in the bladder wall egg injection mouse model of urogenital schistosomiasis.
A Proteomics and other Omics approach in the context of farmed fish welfare and biomarker discovery
Authors: Raposo de Magalhães Cláudia Sofia Ferreira , Cerqueira Marco Alexandre Cavaco , Schrama Denise , Moreira Márcio Júlio Vicente , Boonanuntanasarn Surintorn , Rodrigues Pedro Miguel Leal 
Published: November 2018

AbstractThe rapid and intensive growth of aquaculture over the last decade, poses a tremendous challenge to this industry in order to comply with the latest guidelines, established to minimise its negative effects on the environment, animal welfare and public health. Farmed fish welfare has become one of the main priorities towards sustainable aquaculture production with several initiatives launched by the European Union within the framework of the 2030 agenda. It is clear that an unbiased and reliable way to access farmed fish welfare needs to be implemented due to the lack of reliable indicators and standardised methods that are used at present.In this review, we start by addressing the status quo of animal and fish welfare definition in particular, describing the methods and assays currently used to measure it. We then explain why we believe these methods are unreliable and why there is a need to establish new ones that will promote productivity and consumer's acceptance of farmed fish. The establishment of a new type of welfare biomarkers using cutting‐edge technologies like proteomics and other omics technologies is proposed as a solution to this issue. Therefore, we provide a brief description of these new methodologies, describing for each one how they can improve our scientific knowledge and the role they can play in farmed fish welfare biomarker discovery.
Effect of high‐density lipoprotein on oocyte maturation and bovine embryo development in vitro
Authors: Rincón Joao Alveiro Alvarado , Pradieé Jorgea , Remião Mariana Härter , Collares Tiago Veiras , Mion Bruna , Gasperin Bernardo Garziera , Tomazele Rovani Monique , Corrêa Marcio Nunes , Pegoraro Ligia Margareth Cantarelli , Schneider Augusto 
Published: November 2018

AbstractHigh‐density lipoprotein (HDL) is the main lipoprotein in the follicular fluid, and it has anti‐inflammatory, antioxidant and cryoprotectant properties. The anti‐inflammatory potential and antioxidant potential are derived from its lipid composition, especially the apolipoprotein AI (ApoAI) and paraoxonase 1 (PON1). The aim of this study was to evaluate the effect of HDL during in vitro maturation (IVM) on oocyte maturation and early bovine embryo development. For this, cumulus–oocyte complexes (COCs) were obtained from bovine ovaries collected at a local slaughterhouse. COCs (n = 2,250) were allocated into three groups (n = 50 COCs/group) according to the addition of HDL protein (HDL‐P) during IVM for 22 hr: 0 (control), 50 and 150 mg/dl. After IVM, COCs were inseminated (in vitro fertilization) and cultivated for 7 days. Total cholesterol concentration, total protein, triglycerides and ApoAI concentrations on IVM medium increased proportionally to HDL‐P addition. However, PON1 activity was not detected in any treatment. The addition of HDL‐P did not affect nuclear maturation rate, endogenous reactive oxygen species and glutathione levels in COCs (p > 0.05). The highest HDL‐P concentration (150 mg/dl) decreased cleavage and blastocyst rate (p < 0.05). Moreover, the HDL‐P 150 mg/dl group had lower cellular count/blastocyst than the 50 mg/dl group (p < 0.05). However, the addition of HDL‐P did not affect relative gene expression of evaluated genes. In conclusion, the complex HDL/ApoAI obtained from human plasma, in the absence of PON1 activity during in vitro oocyte maturation, decreased initial embryo development.
Living Well in Times of Threat: The Importance of Adjustment Processes to Explain Functional Adaptation to Uncertain Security in Expatriates Deployed in the Sudan
Authors: Leder Johannes 
Published: November 2018

AbstractThe present study investigated expatriate humanitarian aid workers’ perceptions and responses to uncertain security while deployed in the Sudan. Interviews conducted in Khartoum (n = 7) and Darfur (n = 17) focused on risk perception, concern for personal security, and strategies used to function well in an insecure environment. Despite a high perceived general risk, as well as broad knowledge and experience with security incidents, participants often expressed low concern. General adjustment processes were drawn on to explain this finding, while different constellations of processes resulted in different patterns of adjustment. Functional adjustment, resulting in adequate risk perception, protective behavior, protection, and low concern, was characterized by a constellation of complementary activation of accommodation and assimilation processes.
Gardner syndrome with maxillofacial manifestation: A case report
Authors: Baldino Maria Eduarda , Koth Valesca Sander , Silva Daniela Nascimento , Figueiredo Maria Antonia , Salum Fernanda Gonçalves , Cherubini Karen 
Published: November 2018

AbstractGardner syndrome is a hereditary disease in which patients develop gastrointestinal polyps, osteomas, desmoid tumors, epidermoid cysts, fibromas, lipomas, and retinal lesions. Dental abnormalities such as supernumerary or impacted teeth, odontomas and dentigerous cysts are also reported. The most serious concern in this syndrome is the extremely high risk of gastrointestinal polyps undergoing malignant transformation. Since the maxillofacial findings usually precede gastrointestinal polyps, the dentist plays a crucial role in the diagnosis of Gardner syndrome, and panoramic radiography is an important tool in the diagnosis of the disease. We report here a case of Gardner syndrome in a patient showing mandibular osteomas and impacted teeth. Also, cases of Gardner syndrome with maxillofacial manifestations reported in the literature were reviewed and compared with ours. According to the findings, osteomas are important manifestations of this syndrome, and regardless of the absence of family history of intestinal polyposis, their occurrence should prompt diagnostic evaluation for this disease.
Is successful treatment of depression in dialysis patients an achievable goal?
Authors: Chilcot Joseph , Hudson Joanna L. 
Published: November 2018

AbstractDepression is undisputedly common among individuals with End‐Stage Kidney Failure and associated with adverse outcomes. It is well recognized that effective treatments for depression are needed within routine dialysis care. But, are we any closer to successfully treating depression in dialysis patients? We consider this question here with respect to two common treatments, antidepressant medication and cognitive behavioural therapy (CBT). Currently, there are limited data from randomized placebo‐controlled trials regarding the acceptability and efficacy of antidepressants. CBT trials appear to show more consistent treatment effects, albeit the feasibility of routine delivery remains unknown. No studies in dialysis patients has evaluated the combined effects of CBT with antidepressants. There is a need to consider pragmatic depression treatment trials in dialysis patients in order to increase study recruitment in order to have more reliable data from which to evaluate the evidence base. Furthermore, we need to understand why treatments work, and for whom do they work? Lastly, addressing issues surrounding treatment acceptability and implementation as part of regular care remain as key challenges that require attention if we are to improve the mental health of individuals on dialysis.
Ichnology of prodeltaic hyperpycnite–turbidite channel complexes and lobes from the Upper Cretaceous Prairie Canyon Member of the Mancos Shale, Book Cliffs, Utah, USA
Authors: Buatois Luis A. , Mángano Maria G. , Pattison Simon A. J. 
Published: November 2018

AbstractThe Upper Cretaceous Prairie Canyon Member of the Mancos Shale, Book Cliffs, Utah, contain outstanding examples of prodeltaic turbidity and hyperpycnal flow deposits. Sandstone‐rich, heterolithic and mudstone‐rich channel fills occur near the north‐west entrance to Tusher Canyon, Gunnison Butte and Bootlegger Wash. Mudstone‐rich and heterolithic‐rich hyperpycnal channel deposits are mostly unbioturbated, locally displaying a few specimens of Phycosiphon incertum, Protovirgularia dichotoma, Rosselia socialis, Schaubcylindrichnus coronus and Palaeophycus tubularis. Sandstone‐rich channel deposits consist of wave‐reworked turbidites and hyperpycnites, containing Helminthoidichnites tenuis, Lockeia siliquaria, Phycodes isp., Phycosiphon incertum, Protovirgularia dichotoma, Rosselia socialis, Skolithos linearis and Fugichnia. Scolicia isp. and Chondrites isp. occur locally. Strata along the south‐west entrance of Tusher Canyon record deposition in a prodelta turbidite lobe, but far from its axis. With the exception of a few specimens of Ophiomorpha isp., bioturbation is restricted to the top of the succession, where Curvolithus simplex, Gyrochorte comosa, Lockeia siliquaria, Palaeophycus tubularis and Ptychoplasma excelsum occur. Strata at Hatch Mesa record deposition in a hyperpycnal lobe, near to its axis. Sandstone beds include Curvolithus simplex, Gyrochorte comosa, Ophiomorpha nodosa, Palaeophycus tubularis, Phycosiphon incertum, Protovirgularia dichotoma, Ptychoplasma excelsum, Schaubcylindrichnus freyi, Skolithos linearis, large specimens of Rosselia socialis and indeterminate crustacean burrows. Chondrites isp. is present in the mudstone. High rates of both episodic and sustained sedimentation, degree of substrate consolidation, freshwater discharge and water turbidity are the most important stress factors in both channels and lobes. Taxonomic composition, uneven distribution of bioturbation through the successions, and overall low ichnodiversity help to distinguish these prodeltaic deposits from bathymetrically equivalent offshore strata in the same basin. Hyperpycnal flow deposits are formed in a wide variety of environmental settings, therefore displaying high ichnological variability. Such variability is summarized by characterising ichnofaunas from four different depositional settings: (i) lakes; (ii) shelf deltas; (iii) shelf‐edge deltas; and (iv) deep‐marine systems.
Candidate gene identification of existing or induced mutations with pipelines applicable to large genomes
Authors: Dong Jiaqiang , Tu Min , Feng Yaping , Zdepski Anna , Ge Fei , Kumar Dibyendu , Slovin Janet P. , Messing Joachim 
Published: November 2018

SummaryBulked segregant analysis (BSA) is used to identify existing or induced variants that are linked to phenotypes. Although it is widely used in Arabidopsis and rice, it remains challenging for crops with large genomes, such as maize. Moreover, analysis of huge data sets can present a bottleneck linking phenotypes to their molecular basis, especially for geneticists without programming experience. Here, we identified two genes of maize defective kernel mutants with newly developed analysis pipelines that require no programing skills and should be applicable to any large genome. In the 1970s, Neuffer and Sheridan generated a chemically induced defective kernel (dek) mutant collection with the potential to uncover critical genes for seed development. To locate such mutations, the dek phenotypes were introgressed into two inbred lines to take advantage of maize haplotype variations and their sequenced genomes. We generated two pipelines that take fastq files derived from next‐generation (nextGen) paired‐end DNA and cDNA sequencing as input, call on several well established and freely available genomic analysis tools to call SNPs and INDELs, and generate lists of the most likely causal mutations together with variant index plots to locate the mutation to a specific sequence position on a chromosome. The pipelines were validated with a known strawberry mutation before cloning the dek mutants, thereby enabling phenotypic analysis of large genomes by next‐generation sequencing.
Immunomodulatory in vitro effects of oclacitinib on canine T‐cell proliferation and cytokine production
Authors: Banovic Frane , Tarigo Jaime , Gordon Hannah , Barber James P. , Gogal Robert M. 
Published: November 2018

BackgroundOclacitinib is a Janus kinase inhibitor used to control pruritus and skin lesions in canine allergic skin disease; its effect on canine T cells is not well‐characterized.Hypothesis/ObjectivesTo evaluate the impact of oclacitinib on cultured T cells using peripheral blood mononuclear cells from dogs.AnimalsSix bluetick coonhounds.Methods and materialsLymphocyte‐enriched cells were incubated with or without the T‐cell mitogen concanavalin A (Con A), oclacitinib (0.5, 1 or 10 μM), ciclosporin (200 ng/mL), Con A + oclacitinib 1 μM and Con A + ciclosporin. We assessed both T‐cell proliferation and the secretion of cytokines.ResultsCiclosporin and oclacitinib both inhibited the spontaneous proliferation of T cells; this effect was significant only after incubation with oclacitinib at 10 μM. At this concentration, oclacitinib significantly reduced the spontaneous secretion of clonal activator cytokines [interleukin (IL)‐2, IL‐15], pro‐inflammatory cytokines (interferon‐gamma (IFN‐γ), IL‐18) and the regulatory cytokine IL‐10; tumour necrosis factor alpha (TNF‐α) and IL‐6 cytokine production was mildly inhibited. After Con A stimulation, only T cells co‐treated with ciclosporin achieved a significant proliferation inhibition and reduction of IL‐2, IL‐10, IL‐15, IL‐18, IFN‐γ and TNF‐α. Surprisingly, oclacitinib at 1 μM (337 ng/mL, corresponding to the oral dosage of 0.4–0.6 mg/kg) did not significantly affect Con A‐stimulated T‐cell proliferation nor cytokine production (IL‐2, IL‐10, IL‐15, IL‐18, IFN‐γ and TNF‐α).ConclusionsAlthough a limited number of dogs were investigated, these preliminary results suggest that oclacitinib appears to have immunosuppressive properties, but only at dosages above those used to treat allergic pruritus in dogs.
Spinal plasticity with motor imagery practice
Authors: Grosprêtre Sidney , Lebon Florent , Papaxanthis Charalambos , Martin Alain 
Published: November 2018

Key points
While a consensus has now been reached on the effect of motor imagery (MI) – the mental simulation of an action – on motor cortical areas, less is known about its impact on spinal structures.
The current study, using H‐reflex conditioning paradigms, examined the effect of a 20 min MI practice on several spinal mechanisms of the plantar flexor muscles.
We observed modulations of spinal presynaptic circuitry while imagining, which was even more pronounced following an acute session of MI practice.
We suggested that the small cortical output generated during MI may reach specific spinal circuits and that repeating MI may increase the sensitivity of the spinal cord to its effects.
The short‐term plasticity induced by MI practice may include spinal network modulation in addition to cortical reorganization.
AbstractKinesthetic motor imagery (MI) is the mental simulation of a movement with its sensory consequences but without its concomitant execution. While the effect of MI practice on cortical areas is well known, its influence on spinal circuitry remains unclear. Here, we assessed plastic changes in spinal structures following an acute MI practice. Thirteen young healthy participants accomplished two experimental sessions: a 20 min MI training consisting of four blocks of 25 imagined maximal isometric plantar flexions, and a 20 min rest (control session). The level of spinal presynaptic inhibition was assessed by conditioning the triceps surae spinal H‐reflex with two methods: (i) the stimulation of the common peroneal nerve that induced D1 presynaptic inhibition (HPSI response), and (ii) the stimulation of the femoral nerve that induced heteronymous Ia facilitation (HFAC response). We then compared the effects of MI on unconditioned (HTEST) and conditioned (HPSI and HFAC) responses before, immediately after and 10 min after the 20 min session. After resting for 20 min, no changes were observed on the recorded parameters. After MI practice, the amplitude of rest HTEST was unchanged, while HPSI and HFAC significantly increased, showing a reduction of presynaptic inhibition with no impact on the afferent‐motoneuronal synapse. The current results revealed the acute effect of MI practice on baseline spinal presynaptic inhibition, increasing the sensitivity of the spinal circuitry to MI. These findings will help in understanding the mechanisms of neural plasticity following chronic practice.
Utilization of ADAS for Improving Idle Stop-and-Go Control
Authors: Jeong Kwangwoo , Lee Hoon , Lee Jaihyun , Yoo Sanghoon , Lee Byungho , Kim Sejun 
Published: November 2018

Idle Stop and Go (ISG), also known as Automatic Engine Stop/Start, has been widely implemented in production vehicles as one of the “Eco” functions that save fuel, and the application has been promoted to meet stringent fuel economy regulations throughout the world. However, the vibration and the hesitation caused by engine stop and restart often discourage the usage. Because a conventional ISG system usually restarts the engine when it sees the brake pedal release, the driver may perceive a delay in immediate vehicle launch. Furthermore, there are some driving conditions where engine on/off is undesirable or unnecessary. A quick stop-and-go situation such as making a complete stop at a stop sign is one of the conditions where ISG would be inappropriate, and in those cases, ISG may irritate the driver or even end up increasing fuel consumption with too frequent engine stop/start.
In order to mitigate aforementioned issues, a utilization of Advanced Driver Assistance System (ADAS) is proposed. With the surrounding traffic information obtained from the ADAS module, ISG control algorithm is able to determine when to turn on or off the engine prior to driver’s input. The applications demonstrated in this paper include the following usage examples: The ISG control logic monitors the movement of the vehicle in front and restarts the engine out of ISG mode before brake release, which eliminates the delay in the following vehicle launch. By employing traffic sign recognition and vehicle location info, the control logic is also able to inhibit engine off when the vehicle stops at stop signs which will avoid unwanted ISG activation.
In this paper, the advanced ISG control logic is introduced, and the real-world vehicle test results are provided with the description of prototype vehicle configuration.