bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variables clínicas, de laboratorio e histopatológicas en Síndrome de hipersensibilidad o erupción por drogas con eosinofilia y síntomas sistémicos (DRESS)
Authors: Ramírez-Cornejo Cristian , Downey-Saldivia Camila , Del Puerto-Troncoso Constanza , Del Barrio- Diaz Pablo , Vera-Kellet Cristian , Andino-Navarrete Romina 
Published: May 2019

Introducción: La reacción a drogas con eosinofilia y síntomas sistémicos (DRESS) es una enfermedad poco frecuente que puede ser letal. Objetivo: Describir los hallazgos clínicos, de laboratorio e histopatológicosen pacientes con DRESS. Metodología: Estudioretrospectivo de fichas clínicas de pacientes conDRESS entre los años 2007 y 2017 con scoreregiSCAR mayor o igual a caso probable. Resultados: Se estudiaron 24 pacientes: 14 fueron mujeres (58,3%), la edad promedio fue 45,04 años DS 17,2(16-78). Los medicamentos frecuentemente implicados fueron Lamotrigina (33,3%) y Carbamazepina (20,8%).La latencia fue de 28 días DS 17,7 (10-90). La clínica más frecuente fue prurito 87,5%, fiebre 75%, edema facial 62,5% y adenopatías 45,8%. En laboratorio lo más alterado fueron pruebas hepáticas (70,8%) yeosinofilia (45,8%). 11 pacientes (45,8%) presentaroneosinófilos en la histopatología y 21 pacientes (87,5%)fueron tratados con corticoides. La mortalidad fue de11,1% (2 pacientes) por causas distintas a DRESS.Discusión: DRESS es una reacción adversa a medicamentos severa con hallazgos clínicos y de laboratorio muy variados y evolutivos, requiriendo su conocimiento para no retrasar su diagnóstico ytratamiento.
APOE Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points
Authors: Toledo Jon B. , Habes Mohamad , Sotiras Aristeidis , Bjerke Maria , Fan Yong , Weiner Michael W. , Shaw Leslie M. , Davatzikos Christos , Trojanowski John Q. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: May 2019

There are conflicting results regarding how APOE genotype, the strongest genetic risk factor for Alzheimer’s disease (AD), influences spatial and longitudinal amyloid-β (Aβ) deposition and its impact on the selection of biomarker cut-points. In our study, we sought to determine the impact of APOE genotype on cross-sectional and longitudinal florbetapir positron emission tomography (PET) amyloid measures and its impact in classification of patients and interpretation of clinical cohort results. We included 1,019 and 1,072 Alzheimer’s Disease Neuroimaging Initiative participants with cerebrospinal fluid Aβ1 - 42 and florbetapir PET values, respectively. 623 of these subjects had a second florbetapir PET scans two years after the baseline visit. We evaluated the effect of APOE genotype on Aβ distribution pattern, pathological biomarker cut-points, cross-sectional clinical associations with Aβ load, and longitudinal Aβ deposition rate measured using florbetapir PET scans. 1) APOE ɛ4 genotype influences brain amyloid deposition pattern; 2) APOE ɛ4 genotype does not modify Aβ biomarker cut-points estimated using unsupervised mixture modeling methods if white matter and brainstem references are used (but not when cerebellum is used as a reference); 3) findings of large differences in Aβ biomarker value differences based on APOE genotype are due to increased probability of having AD neuropathology and are most significant in mild cognitive impairment subjects; and 4) APOE genotype and age (but not gender) were associated with increased Aβ deposition rate. APOE ɛ4 carrier status affects rate and location of brain Aβ deposition but does not affect choice of biomarker cut-points if adequate references are selected for florbetapir PET processing.
Neuropsychiatric Symptoms and Risk of Progression to Alzheimer’s Disease Among Mild Cognitive Impairment Subjects
Authors: Dietlin Simon , Soto Maria , Kiyasova Vera , Pueyo Maria , de Mauleon Adelaïde , Delrieu Julien , Ousset Pierre Jean , Vellas Bruno 
Published: May 2019

Background: Neuropsychiatric symptoms (NPS) are prevalent in mild cognitive impairment (MCI), but we do not know much about their role in progression to dementia. Objective: To investigate NPS and the risk of progression to probable Alzheimer’s disease dementia (AD) among subjects with MCI. Methods: 96 MCI participants were followed for 4 years. Progression to probable AD was defined by the change of CDR total score from 0.5 to ≥1, reviewed by an expert consensus panel. NPS were determined using the Neuropsychiatric Inventory (NPI) 12-items. This study analyzed prognostic value of each NPI item and 5 sub-syndromes of NPS (apathy, psychosis, affective, hyperactivity, and vegetative) for prediction of progression to probable AD. A Cox proportional hazard model was used; hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated with time dependent variable to compare the incidence of progression considering presence/absence of any NPS or sub-syndromes throughout the study. Results: The presence of symptoms “agitation/aggression”, “delusions”, and “aberrant motor behavior” significantly increased the risk of probable AD (HR = 3.9; 95% CI = 1.9–8.2; HR = 13.9; 95% CI = 4.1–48.9; HR = 4.3; 95% CI = 1.7–10.3, respectively). The presence of sub-syndromes “psychosis” and “hyperactivity” were also predictors of progression (HR = 14.0; 95% CI = 4.4–44.5; HR = 2.0; 95% CI = 1.1–3.7, respectively). These results did not change after adjusting by potential confounders. Conclusion: Presence of delusions, agitation/aggression, and aberrant motor behavior is predictor of progression to probable AD.
Терористичні загрози закордонним дипломатичним установам України
Authors: Balitskyj V. V. 
Published: May 2019

Стаття присвячена розгляду проблем забезпечення безпеки закордонних дипломатичних установ (ЗДУ) України в умовах виникнення терористичних загроз у країні акредитації. Зокрема, автором проаналізовані вирішення завдань забезпечення безпеки ЗДУ під час терористичних акцій в їх оточенні, при блокуванні представництв терористами та захопленні приміщень установ і їх співробітників як заручників.
Метою статті став пошук ефективних шляхів забезпечення безпеки закордонних дипломатичних установ України та їх персоналу під час терористичних акцій в країнах акредитації.
Наукова новизна статті полягає у дослідженні можливостей розробки сучасної системи організації в ЗДУ, адекватної протидії наявним викликам і загрозам терористичного характеру, а також відповідної актуалізації відповідних правових норм та інструкцій. У статті відпрацьовані конкретні рекомендації щодо дій в екстремальних ситуаціях під час терористичних акцій в оточенні ЗДУ, зокрема, при блокуванні представництв терористами чи захопленні їх приміщень злочинцями, а також утримуванні дипломатичних співробітників як заручників.
Висновки. Негативні тенденції сучасного світового розвитку такі як: прояви міжнародного тероризму, організованої злочинності, контрабанда наркотиків і зброї, нелегальна міграція і торгівля людьми; зростання екологічних і природних катастроф, загроз епідемій та пандемії; збереження ескалації заморожених конфліктів і поява нових джерел напруженості, виникнення кризових ситуацій, зокрема, активізація щодо України внаслідок подій на сході терористичної та розвідувально-підривної діяльності спецслужб РФ, покладають на СЗР України та інші спеціальні державні органи завдання належним чином забезпечувати національну безпеку держави, її закордонних дипломатичних установ, їх співробітників і членів сімей, а також відряджених за кордон українських громадян, обізнаних з відомостями, що становлять державну таємницю. Напрацьована світова практика та удосконалення нормативного регулювання у сфері зазначених питань сприятимуть вирішенню завдань забезпечення безпеки ЗДУ під час терористичних акцій в їх оточенні, при блокуванні представництв терористами та захопленні приміщень установ і їх співробітників як заручників.
Parametric Optimization and Experimental Validation for Nonlinear Characteristics of Passenger Car Suspension System
Authors: Mohd Avesh , Srivastava Rajeev 
Published: May 2019

The study deals with the design of the automotive suspension system to better dynamic characteristics in an uncertain operating atmosphere. Vehicle design parameters are to be optimized to achieve better passengers comfort, vehicle body stability, and road holding as the measure of suspension system performance improvement. The design of experiments gives the optimum parametric combination in the domain on the basis of vertical body acceleration data obtained by simulation of a 2-DOF nonlinear quarter car model. Moreover, the nonlinear hysteric behavior foremost design parameters have been characterized through the theoretical and experimental analysis in order to validate the design and to check the analogical viability of the derived model. Finally, the proposed methodology ascertains the optimum design of the suspension system in the time and cost-effective manner. The developed passive design of car suspension system exhibits excellent vibrational characteristics and convinces the acceptable range of vehicle vibration as suggested by ISO-2631-1997.
PENGARUH MICRO WAVE DIATHERMY DAN TERAPI LATIHAN PADA OSTEOARTHRITIS GENU
Authors: Purnomo Didik , Abidin Zainal , Wicaksono Riza Dwi 
Published: May 2019

Latar Belakang : Riset Kesehatan Dasar (Riskesdas) tahun 2013, pravalensi penyakit sendi berdasarkan diagnosa kesehatan di Indonesia 11,9% dan berdasarkan gejala 24,7%. Pravalensi berdasarkan diagnosis tenaga kesehatan tertinggi di bali 19,3% sedangkan berdasarkan gejala tertinggi di Nusa Tenggara Timur 33,1%, jawa barat 32,1%, DKI Jakarta 21,8% jika dilihat dari karakteristik umur , pravalensi tertinggi pada umur ≥ 75 tahun (54,8%) penderita wanita juga lebih banyak (27,5%) dibandingkan dengan pria (21,8%)(Riskesdas, 2013) Penelitian ini dilakukan di RSUD dr. H. Soewondo kendal pada bulan November 2017 dengan menggunakan sampel sebanyak 8 orang partisipan dengan metode quasi eksperimen jenis pretest-posttest.
Tujuan : mengetahui pengaruh penggunaan Micro Wave Diathermy, Latihan aktif, Resisted active exercise dan Hold Relax pada osteoarthritis genu
Hasil : uji normalitas data dengan saphiro-wilk test mendapatkan hasil distribusi data normal dengan nilai sig. untuk VAS sebelum terapi 0.168, VAS sesudah terapi 0.273, LGS sebelum terapi 0.592, LGS sesudah terapi 0.476, skor Jette sebelum terapi 0.507 dan skor Jette setelah terapi 0.501. uji hipotesis menggunakan paired sample t test didapatkan hasil berupa perubahan signifikan antara sebelum terapi dibandingkan dengan setelah terapi ditunjukan dengan sig. (2-tailed) untuk VAS 0,000, sig. (2-tailed) untuk LGS 0,001 dan sig. (2-tailed) untuk skor Jette 0,000.
Kesimpulan : intervensi fisioterapi berupa Micro Wave Diathermy, Latihan aktif, Resisted active exercise dan Hold Relax terbukti mampu menurunkan derajat nyeri, meningkatkan lingkup gerak sendi dan Kemampuan fungsional aktivitas lutut partisipan.
Aplicación del programa de intención emprendedora en el distrito de ate
Authors: Calla Vásquez Kriss , Judith Yangali Vicente , José Rodríguez López , Guerrero Bejarano Maria Auxiliadora 
Published: May 2019

La investigación tiene como objetivo determinar en qué medida la aplicación del programa de emprendimiento y creación de microempresas desarrolla la competitividad académica en el ámbito educativo en el distrito de Ate – Lima, durante el 2019. Es una investigación aplicada, el diseño de la investigación es experimental, de nivel cuasi experimental, con enfoque cuantitativo y de corte transversal. La población lo constituyen 1409 individuos del distrito de Ate, la muestra es no probabilística conformado por 128 individuos. La técnica utilizada es la encuesta y el instrumento es el cuestionario. Se busca obtener resultados a partir de la aplicación del programa de emprendimiento y creación de microempresas que influyen significativamente en la competitividad empresarial en el ámbito educativo en Ate, Lima. Los resultados de la primera fase de la Aplicación del Programa de Emprendimiento y creación de microempresas, en la dimensión intención emprendedora se concluye que: El 100% de los encuestados muestran actitud positiva hacia el emprendimiento entre los pobladores de Ate, considerando importante la opinión de la familia y amigos con respecto a la creación de empresas; apreciándose el deseo de control conductual en la creación de la empresa, y la decisión de crear su propia empresa.
Relaciones generacionales: Entre la violencia y el afecto
Authors: De La Cruz Landazuri María Gabriela , Aguilar Rodríguez Freddy , Chicaiza Aucapiña Italo 
Published: May 2019

El presente trabajo tiene como fin provocar una reflexión profunda sobre las relaciones afectivas entre adultos y niños, para determinar su grado de incidencia en el crecimiento y desarrollo saludable de jóvenes, niños y niñas.
Para alcanzar este objetivo se extraen cifras de la línea base realizada en la provincia del Napo, corroborada y comparada con otros trabajos investigativos de la localidad y a nivel nacional; seguidamente se presentan los resultados obtenidos en la encuesta cantonal sobre el trato entre adultos y niños/as, desde el Concejo Cantonal de la Niñez y Adolescencia. Finalmente, se analizarán las denuncias de vulneración de derechos registradas por la Junta Cantonal de Protección de Derechos para intentar desembocar en una especie de bosquejo hacia la construcción de una cultura de paz.
La complejidad del tema provoca un abordaje interdisciplinario, más allá de las estadísticas y concepciones hay que tener una mirada plural y amplia que ahuyente las tendencias antagónicas que consideran sin valor alguno el tema afectivo, y sentencian invariables los patrones de relación socio-afectivas.
Palabras claves: Socialización, jóvenes, infancias, vulneración, violencias.
A reflexão na prática docente: alguns limites para a sua efectivação. O caso da informática na educação
Authors: Ribeiro Nunes Leonel Jorge 
Published: May 2019

A formação de professores tem sido alvo de muitas investigações, demonstrando a necessidade de se repensar e procurar alternativas viáveis para a sua continuidade. Sob esta perspectiva, surgiu nas últimas décadas uma tendência denominada de Formação Reflexiva de Professores, fundamentada num exame da situação actual da docência, e que não separa a formação inicial da formação continua, tendo como referencia a prática docente.
Como ponto central desta tendência recente, apresenta-se a constituição do professor reflexivo, a partir de um novo entendimento da prática docente, onde a experiência ganha relevância enquanto parte do «savoir faire» próprio da profissão.
Este texto pretende discutir a reflexão como elemento da prática docente, preocupado em perceber como ocorre, no ambiente da docência, a sua efectivação, a sua elaboração no quotidiano do professor, procurando entender alguns dos limites que se apresentam.
ACRONYM. III. Radial Velocities for 336 Candidate Young Low-mass Stars in the Solar Neighborhood, Including 77 Newly Confirmed Young Moving Group Members
Authors: Schneider Adam C. , Shkolnik Evgenya L. , Allers Katelyn N. , Kraus Adam L. , Liu Michael C. , Weinberger Alycia J. , Flagg Laura 
Published: May 2019

Abstract
Young, low-mass stars in the solar neighborhood are vital for completing the mass function for nearby, young coeval groups, establishing a more complete census for evolutionary studies, and providing targets for direct-imaging exoplanet and/or disk studies. We present properties derived from high-resolution optical spectra for 336 candidate young nearby, low-mass stars. These include measurements of radial velocities and age diagnostics such as Hα and Li λ6707 equivalent widths. Combining our radial velocities with astrometry from Gaia DR2, we provide full 3D kinematics for the entire sample. We combine the measured spectroscopic youth information with additional age diagnostics (e.g., X-ray and UV fluxes, color–magnitude diagram positions) and kinematics to evaluate potential membership in nearby, young moving groups and associations. We identify 77 objects in our sample as bona fide members of 10 different moving groups, 14 of which are completely new members or have had their group membership reassigned. We also reject 44 previously proposed candidate moving group members. Furthermore, we have newly identified or confirmed the youth of numerous additional stars that do not belong to any currently known group and find 69 comoving systems using Gaia DR2 astrometry. We also find evidence that the Carina association is younger than previously thought, with an age similar to the β Pictoris moving group (∼22 Myr).
Exploring Reionization-era Quasars. IV. Discovery of Six New z ≳ 6.5 Quasars with DES, VHS, and unWISE Photometry
Authors: Yang Jinyi , Wang Feige , Fan Xiaohui , Yue Minghao , Wu Xue-Bing , Li Jiang-Tao , Bian Fuyan , Jiang Linhua , Bañados Eduardo , Beletsky Yuri 
Published: May 2019

Abstract
This is the fourth paper in a series of publications aiming at discovering quasars at the epoch of reionization. In this paper, we expand our search for z ∼ 7 quasars to the footprint of the Dark Energy Survey (DES) Data Release One (DR1), covering ∼5000 deg2 of a new area. We select z ∼ 7 quasar candidates using deep optical, near-infrared (near-IR) and mid-infrared (mid-IR) photometric data from the DES DR1, the VISTA Hemisphere Survey, the VISTA Kilo-degree Infrared Galaxy survey, the UKIRT InfraRed Deep Sky Surveys—Large Area Survey (ULAS), and the unblurred coadds from the Wide-field Infrared Survey Explore (WISE) images (unWISE). The inclusion of DES and unWISE photometry allows the search to reach ∼1 mag fainter, comparing to our z ≳ 6.5 quasar survey in the northern sky. We report the initial discovery and spectroscopic confirmation of six new luminous quasars at z > 6.4, including an object at z = 7.02, the fourth quasar yet known at z > 7, from a small fraction of candidates observed thus far. Based on the recent measurement of z ∼ 6.7 quasar luminosity function using the quasar sample from our survey in the northern sky, we estimate that there will be ≳55 quasars at z > 6.5 at M
1450 < −24.5 in the full DES footprint.
Probing the Time Variation of the Effective Newton’s Constant with Optimal Redshift Weights
Authors: Li Jian , Zhao Gong-Bo 
Published: May 2019

Abstract
We propose a new method for probing the time variation of the effective Newton’s constant G
eff, based on the optimal redshift weighting scheme, and demonstrate the efficacy using the DESI galaxy spectroscopic survey. We find that with the optimal redshift weights, the evolution of

can be significantly better measured: the uncertainty of

can be reduced by a factor of 2.2 ∼ 12.8 using the DESI Bright Galaxy Survey sample at z ≲ 0.45, and by a factor of 1.3 ∼ 4.4 using the DESI Emission Line Galaxies sample covering 0.65 ≲ z ≲ 1.65.
A Magnetic Pressure Front Upstream of the Heliopause and the Heliosheath Magnetic Fields and Plasma, Observed during 2017
Authors: Burlaga L. F. , Ness N. F. , Berdichevsky D. B. , Jian L. K. , Park J. , Mostafavi P. , Richardson J. D. 
Published: May 2019

Abstract

Voyager 1 (V1), moving in the interstellar magnetic field, observed an increase in the daily averages of B beginning on day ≈346, 2016, rising to a local maximum on day ≈382, and declining nearly monotonically for the most part until day 720, measured from 2016.0. A pressure front was observed during a ≈35-day interval beginning on day 346, 2016. The pressure front observed by V1 was not a shock, although one might expect it to evolve into a shock. Voyager 2 (V2) observed the distant heliosheath during 2017. The average B in the heliosheath was relatively high, 0.130 nT. The distribution of azimuthal angles had two nearly equal maxima at approximately 90° and 180°. An unusual transition of the BT component from a large “away” sector to a large “toward” sector occurred during 2017 from day 101 to day 239. Abrupt but small changes in magnetic polarity occurred between day 146 and day 239, when the average BT component of B was close to zero. Changes in the >70 MeV nucleon−1 cosmic-ray intensity were qualitatively related to the B(t) profile described by the CR-B relationship. There was no net decrease in magnetic flux at V2 in the heliosheath during 2017 that might be attributed to ongoing magnetic reconnection in the heliosheath. Small-scale increments in B can be described by a q-Gaussian distribution with q = 1.64 ± 0.02 for hourly averages of B and q = 1.54 ± 0.08 for daily averages of B.
Polygram Stars: Resonant Tidal Excitation of Fundamental Oscillation Modes in Asynchronous Stellar Coalescence
Authors: MacLeod Morgan , Vick Michelle , Lai Dong , Stone James M. 
Published: May 2019

Abstract
The prevalence of binary stars at close separations implies that many of these systems will interact or merge during the binary’s lifetime. This paper presents hydrodynamic simulations of the scenario of binary coalescence through unstable mass transfer, which drives the pair to closer separations. When the donor star does not rotate synchronously with respect to the orbit, dynamical tidal waves are excited in its envelope. We show that resonance crossings with high azimuthal order (m ∼ 3 to 6) fundamental modes induce a visible “polygram” distortion to the star. As the binary orbit tightens, the system sweeps through resonance with modes of decreasing azimuthal order, which are selectively excited. We compare our hydrodynamic simulations to predictions from linear theory of resonant-mode excitation. The linear theory provides an estimate of mode amplitudes to within a factor of two, even as the oscillations become quite nonlinear as the stars coalesce. We estimate that a wave with 10% radial amplitude generates approximately 1% photometric variability; this may be detectable if such a binary coalescence is caught in action by future photometric all-sky surveys.
Probing an X-Ray Flare Pattern in Mrk 421 Induced by Multiple Stationary Shocks: A Solution to the Bulk Lorentz Factor Crisis
Authors: Hervet Olivier , Williams David A. , Falcone Abraham D. , Kaur Amanpreet 
Published: May 2019

Abstract
The common observations of multiple radio VLBI stationary knots in high-frequency-peaked BL Lacs (HBLs) can be interpreted as multiple recollimation shocks accelerating particles along jets. This approach can resolve the so-called “bulk Lorentz factor crisis” of sources with a high Lorentz factor deduced from maximum γ–γ opacity and fast variability and apparently inconsistent slow/stationary radio knots. It also suggests that a unique pattern of the nonthermal emission variability should appear after each strong flare. Taking advantage of the 13 yr of observation of the HBL Mrk 421 by the X-ray Telescope on the Neil Gehrels Swift Observatory (Swift-XRT), we probe for such an intrinsic variability pattern. Its significance is then statistically estimated via comparisons with numerous similar simulated light curves. A suggested variability pattern is identified, consistent with a main flare emission zone located in the most upstream 15.3 GHz radio knot at 0.38 mas from the core. Subsequent flux excesses in the light curve are consistent with a perturbation crossing all of the downstream radio knots with a constant apparent speed of 45c. The significance of the observed variability pattern not arising from stochastic processes is found above three standard deviations, opening a promising path for further investigations in other blazars and with other energy bands. In addition to highlighting the role of stationary radio knots as high-energy particle accelerators in jets, the developed method allows estimates of the apparent speed and size of a jet perturbation without the need to directly observe any motion in jets.