bluuebunny/crossref_metadata_2025_split huggingface dataset:
The nomenclature of two names proposed for Portuguese taxa of Calendula (Asteraceae) by Lange in 1883
Authors: FIGUEIREDO ESTRELA , SMITH GIDEON F. , SILVEIRA PAULO 
Published: July 2018

Confusion has existed about the status and authorship of some of the new names published in an article entitled ‘Notas’ that appeared in 1883 in the first volume of the Portuguese journal Boletim da Sociedade Broteriana. The ‘Notas’ consisted of several notes (A to I); one of these, Note A, was unambiguously authored by Ficalho (Francisco Manuel de Melo Breyner; 1837–1903), as Conde de Ficalho, and ‘Lisbon’ appeared at the bottom of the note. It is not immediately clear who authored the other notes. However, these must be attributed to Henriques (Júlio Augusto Henriques; 1838–1928), the editor of the volume. Perhaps counter-intuitively, these ‘Notas’ complemented another paper, a list of plants distributed to members of the society (“Especies distribuidas”), which appeared on pages 27–47 of the same volume. For this reason the ‘Notas’ were often cryptic, and genera, for example, were referenced by their initial letters only. For instance, in Note E a new species was described in Latin, under the genus “P.”; a full name was not provided for the genus, and neither for the new species. However, in the article on species distributed (p. 42) Pulicaria microcephala Lange is listed under the genus Pulicaria and is cross-referenced back to Note E. Pulicaria microcephala is not listed in the International Plant Name Index (IPNI), but is recorded in the Euro+Med PlantBase by Greuter (2006+), where it is treated as an accepted name with the citation Lange in Bol. Soc. Brot. 1: 42, 50. 1883.
Deterministic Wind Speed Predictions with Analog-Based Methods over Complex Topography
Authors: Plenković Iris Odak , Delle Monache Luca , Horvath Kristian , Hrastinski Mario 
Published: July 2018

AbstractThe performance of analog-based and Kalman filter (KF) postprocessing methods is tested in climatologically and topographically different regions for point-based wind speed predictions at 10 m above the ground. The results are generated using several configurations of the mesoscale numerical weather prediction model ALADIN. This study shows that deterministic analog-based predictions (ABPs) improve the correlation between predictions and measurements while reducing the forecast error, with respect to both the starting model predictions and the KF-based correction. While the KF generally outperforms the ABPs in bias reduction, the combination of the KF and analog approach can be similarly successful. In the coastal complex area, characterized with a larger frequency of strong wind, the ABPs are more successful in reducing the dispersion error than the KF. The application of the KF algorithm to the analogs in the so-called analog space (KFAS) is the least prone to standard deviation underestimation among the ABPs. All ABPs improve the prediction of larger-than-diurnal motions, and KFAS is superior among all ABPs in predicting alternating wind regimes on time scales shorter than a day. The ABPs better distinguish different wind speed categories in the coastal complex terrain by using a higher-resolution model input. Differences among starting model and postprocessed forecasts in other types of terrain are less pronounced.
Systematic Review of Voice Outcomes for Injection Laryngoplasty Performed under Local vs General Anesthesia
Authors: Ballard Daniel P. , Abramowitz Jason , Sukato Daniel C. , Bentsianov Boris , Rosenfeld Richard M. 
Published: July 2018

ObjectiveTo assist otolaryngologists in counseling patients with hoarseness who would benefit from injection laryngoplasty on whether or not to perform the procedure in the office vs the operating room.Data SourcesCochrane library, CINAHL, PubMed, and EMBASE.Review MethodsSystematic review using Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) reporting standards of English‐language articles that compared voice outcomes for in‐office and in the operating room injection laryngoplasty. Two independent investigators assessed study eligibility, rated the quality using Methodological Index for Non‐Randomized Studies (MINORS), and abstracted data for comparative analysis.ResultsOf 689 initial studies, 4 observational, comparative studies met inclusion criteria, with follow‐up of 2 weeks to 12 months postinjection. Laryngoplasty was most commonly performed for vocal fold immobility with varied injectable materials (micronized dermis, hyaluronic acid, and calcium hydroxyapatite). Follow‐up ranged from 2 weeks to 12 months. Voice outcomes improved in all studies, with comparable improvement for patients injected in the office vs the operating room (P =. 42 to P =. 88). Meta‐analysis of 3 studies showed no difference in Voice Handicap Index–10 voice outcomes by treatment setting (standardized mean difference −0.11, P =. 441), with the 95% confidence interval (–0.405 to 0.176), making it unlikely that anything larger than a small or trivial difference was missed.ConclusionOur systematic review makes it unlikely that meaningful clinical differences exist in postprocedure voice outcomes for injection laryngoplasty in the office vs the operating room.
Equipment, staffing, and provision of radiotherapy in Lombardy, Italy: Results of three surveys performed between 2012 and 2016
Authors: Palazzi Mauro F. , Soatti Carlo , Jereczek-Fossa Barbara A. , Cazzaniga Luigi F. , Antognoni Paolo , Gardani Gianstefano , Amadori Marcello , Baio Ambrogia , Beltramo Giancarlo , Bignardi Mario , Bracelli Stefano , Buffoli Alberto , Castiglioni Simona , Catalano Gianpiero , Di Muzio Nadia , Fallai Carlo , Fariselli Laura , Frata Paolo , Gramaglia Alberto , Italia Corrado , Ivaldi Giovanni , Lombardi Fabrizio , Magrini Stefano M. , Nava Simonetta , Sarti Enrico , Scandolaro Luciano , Scorsetti Marta , Stiglich Francesco , Tortini Roberto , Valdagni Riccardo , Valvo Francesca , Vavassori Vittorio , Sbicego Elena L. , Tonoli Sandro , Orecchia Roberto 
Published: July 2018

Introduction: Several efforts are being implemented at the European level to measure provision of up-to-date radiation treatments across the continent. Methods: A snapshot survey involving all radiation oncology centers within Lombardy, Italy, was performed in 2012 and repeated in 2014 and 2016, in cooperation with regional governmental officers. Centers were asked to provide detailed information concerning all individual patients being treated on the index day, and to report data on available local resources. Results: We observed an increase in the number of centers and of megavoltage units (MVU) (from 76 to 87, i.e., 8.7 MVU per million inhabitants in 2016). Mean number of MVU per center was 2.5. Average age of MVU increased from 5.3 to 7.5 years and patients on the waiting list also increased. Conformal 3D radiotherapy (RT) treatments decreased from 56% to 42% and were progressively replaced by intensity-modulated RT treatments (from 39% to 49%). Waiting times were overall satisfactory. Radiation oncologists treated on average 152 and radiation therapists 100 RT courses per year. Average reimbursement per course was €4,879 (range €2,476–€8,014). Conclusions: The methodology of snapshot survey proved feasible and provided valuable information about radiation oncology provision and accessibility in Lombardy.
Current understanding of trigeminal ganglion structure and function in headache
Authors: Messlinger Karl , Russo Andrew F 
Published: July 2018

Introduction The trigeminal ganglion is unique among the somatosensory ganglia regarding its topography, structure, composition and possibly some functional properties of its cellular components. Being mainly responsible for the sensory innervation of the anterior regions of the head, it is a major target for headache research. One intriguing question is if the trigeminal ganglion is merely a transition site for sensory information from the periphery to the central nervous system, or if intracellular modulatory mechanisms and intercellular signaling are capable of controlling sensory information relevant for the pathophysiology of headaches. Methods An online search based on PubMed was made using the keyword “trigeminal ganglion” in combination with “anatomy”, “headache”, “migraine”, “neuropeptides”, “receptors” and “signaling”. From the relevant literature, further references were selected in view of their relevance for headache mechanisms. The essential information was organized based on location and cell types of the trigeminal ganglion, neuropeptides, receptors for signaling molecules, signaling mechanisms, and their possible relevance for headache generation. Results The trigeminal ganglion consists of clusters of sensory neurons and their peripheral and central axon processes, which are arranged according to the three trigeminal partitions V1–V3. The neurons are surrounded by satellite glial cells, the axons by Schwann cells. In addition, macrophage-like cells can be found in the trigeminal ganglion. Neurons express various neuropeptides, among which calcitonin gene-related peptide is the most prominent in terms of its prevalence and its role in primary headaches. The classical calcitonin gene-related peptide receptors are expressed in non-calcitonin gene-related peptide neurons and satellite glial cells, although the possibility of a second calcitonin gene-related peptide receptor in calcitonin gene-related peptide neurons remains to be investigated. A variety of other signal molecules like adenosine triphosphate, nitric oxide, cytokines, and neurotrophic factors are released from trigeminal ganglion cells and may act at receptors on adjacent neurons or satellite glial cells. Conclusions The trigeminal ganglion may act as an integrative organ. The morphological and functional arrangement of trigeminal ganglion cells suggests that intercellular and possibly also autocrine signaling mechanisms interact with intracellular mechanisms, including gene expression, to modulate sensory information. Receptors and neurotrophic factors delivered to the periphery or the trigeminal brainstem can contribute to peripheral and central sensitization, as in the case of primary headaches. The trigeminal ganglion as a target of drug action outside the blood-brain barrier should therefore be taken into account.
An Evidence-Based Review of Statin Use in Patients With Nonalcoholic Fatty Liver Disease
Authors: Sigler Meredith A , Congdon Lee , Edwards Krystal L 
Published: July 2018

Background: Nonalcoholic fatty liver disease (NAFLD) is a common complication in patients with metabolic syndrome. The role of statin therapy specifically for the treatment of NAFLD remains unknown. The aim of this review is to discuss outcomes of recent articles analyzing statin therapy in patients with NAFLD. Findings: A total of 12 trials met the inclusion criteria. Statins were not found to increase the prevalence of NAFLD once confounding variables were considered. Statins were also found to be beneficial in treating dyslipidemia and improving liver function. Histological liver outcomes in patients with NAFLD were controversial. One trial found a reduction in the incidence of hepatocellular carcinoma associated with the use of statins. Conclusions: Overall, therapy with statins appears to be safe for use in patients with NAFLD. Several trials have validated the use of statins for the treatment of dyslipidemia; however, it remains unknown as to whether statins should be used to specifically treat NAFLD.
A survey of opinion: When to start oral anticoagulants in patients with acute ischaemic stroke and atrial fibrillation?
Authors: Munn David , Abdul-Rahim Azmil H , Fischer Urs , Werring David J , Robinson Thompson G , Dawson Jesse 
Published: July 2018

Introduction There is uncertainty regarding the optimal timing for initiation of oral anticoagulant treatment in patients with recent ischaemic stroke and atrial fibrillation. We surveyed the current UK practice and assessed clinician’s opinions of when to use oral anticoagulant in recent stroke patients with atrial fibrillation. Patients and methods An online survey was sent to stroke physicians within the United Kingdom via their national societies. Results One hundred and twenty-one clinicians responded to the survey. Ninety-five percent of responders agreed that there was uncertainty regarding timing of oral anticoagulant initiation after atrial fibrillation-related ischaemic stroke. Thirty-six percent of responders followed the ‘1–3–6–12’ European Society of Cardiology guidelines recommendation. Uncertainty was greater in cases of moderate stroke than in cases of transient ischaemic attack (TIA), mild or severe stroke. Eighty-eight percent of responders would be willing to participate in a clinical trial of early versus later initiation of oral anticoagulant after stroke. Direct-acting oral anticoagulants were the preferred oral anticoagulant of choice. Discussion and Conclusion There is a lack of consensus amongst stroke physicians for when to initiate oral anticoagulant to prevent recurrence in stroke patients with atrial fibrillation. There is little uncertainty regarding TIA. A clinical trial assessing the use of early versus later initiation of direct-acting oral anticoagulant in patients with recent ischaemic stroke and atrial fibrillation would be beneficial.
关于西汉诸侯王玺印的一些推测 一一从长沙王玺和长沙王印说起
Authors: 罗小华  
Published: July 2018

摘要 关于西汉诸侯王的玺印, 传世文献的记载并不多, 相关实物更是少之又少, 目前仅有 “滇王之印” 是考古发掘出土的夷王之印, 另有三王之玺和二王之印也只留下封泥。2009 年, 公安部门追缴回来的 “长沙王玺” 和 “长沙王印” , 为同一区域的诸侯王所有, 为学界探讨西汉时期诸侯王的玺印制度提供了非常重要的依据。
Patient-Reported Toxicity During Pelvic Intensity-Modulated Radiation Therapy: NRG Oncology–RTOG 1203
Authors: Klopp Ann H. , Yeung Anamaria R. , Deshmukh Snehal , Gil Karen M. , Wenzel Lari , Westin Shannon N. , Gifford Kent , Gaffney David K. , Small William , Thompson Spencer , Doncals Desiree E. , Cantuaria Guilherme H.C. , Yaremko Brian P. , Chang Amy , Kundapur Vijayananda , Mohan Dasarahally S. , Haas Michael L. , Kim Yong Bae , Ferguson Catherine L. , Pugh Stephanie L. , Kachnic Lisa A. , Bruner Deborah W. 
Published: July 2018

Purpose NRG Oncology/RTOG 1203 was designed to compare patient-reported acute toxicity and health-related quality of life during treatment with standard pelvic radiation or intensity-modulated radiation therapy (IMRT) in women with cervical and endometrial cancer. Methods Patients were randomly assigned to standard four-field radiation therapy (RT) or IMRT radiation treatment. The primary end point was change in patient-reported acute GI toxicity from baseline to the end of RT, measured with the bowel domain of the Expanded Prostate Cancer Index Composite (EPIC). Secondary end points included change in patient-reported urinary toxicity, change in GI toxicity measured with the Patient-Reported Outcome Common Terminology Criteria for Adverse Events, and quality of life measured with the Trial Outcome Index. Results From 2012 to 2015, 289 patients were enrolled, of whom 278 were eligible. Between baseline and end of RT, the mean EPIC bowel score declined 23.6 points in the standard RT group and 18.6 points in the IMRT group ( P = .048), the mean EPIC urinary score declined 10.4 points in the standard RT group and 5.6 points in the IMRT group ( P = .03), and the mean Trial Outcome Index score declined 12.8 points in the standard RT group and 8.8 points in the IMRT group ( P = .06). At the end of RT, 51.9% of women who received standard RT and 33.7% who received IMRT reported frequent or almost constant diarrhea ( P = .01), and more patients who received standard RT were taking antidiarrheal medications four or more times daily (20.4% v 7.8%; P = .04). Conclusion Pelvic IMRT was associated with significantly less GI and urinary toxicity than standard RT from the patient’s perspective.
Ado-Trastuzumab Emtansine for Patients With HER2-Mutant Lung Cancers: Results From a Phase II Basket Trial
Authors: Li Bob T. , Shen Ronglai , Buonocore Darren , Olah Zachary T. , Ni Ai , Ginsberg Michelle S. , Ulaner Gary A. , Offin Michael , Feldman Daniel , Hembrough Todd , Cecchi Fabiola , Schwartz Sarit , Pavlakis Nick , Clarke Stephen , Won Helen H. , Brzostowski Edyta B. , Riely Gregory J. , Solit David B. , Hyman David M. , Drilon Alexander , Rudin Charles M. , Berger Michael F. , Baselga José , Scaltriti Maurizio , Arcila Maria E. , Kris Mark G. 
Published: July 2018

Purpose Human epidermal growth factor receptor 2 ( HER2, ERBB2)–activating mutations occur in 2% of lung cancers. We assessed the activity of ado-trastuzumab emtansine, a HER2-targeted antibody-drug conjugate, in a cohort of patients with HER2-mutant lung cancers as part of a phase II basket trial. Patients and Methods Patients received ado-trastuzumab emtansine at 3.6 mg/kg intravenously every 3 weeks until progression. The primary end point was overall response rate using Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. A Simon two-stage optimal design was used. Other end points included progression-free survival and toxicity. HER2 testing was performed on tumor tissue by next generation sequencing, fluorescence in situ hybridization, immunohistochemistry, and protein mass spectrometry. Results We treated 18 patients with advanced HER2-mutant lung adenocarcinomas. The median number of prior systemic therapies was two (range, zero to four prior therapies). The partial response rate was 44% (95% CI, 22% to 69%), meeting the primary end point. Responses were seen in patients with HER2 exon 20 insertions and point mutations in the kinase, transmembrane, and extracellular domains. Concurrent HER2 amplification was observed in two patients. HER2 immunohistochemistry ranged from 0 to 2+ and did not predict response, and responders had low HER2 protein expression measured by mass spectrometry. The median progression-free survival was 5 months (95% CI, 3 to 9 months). Toxicities included grade 1 or 2 infusion reactions, thrombocytopenia, and elevated hepatic transaminases. No patient stopped therapy as a result of toxicity or died on study. Conclusion Ado-trastuzumab emtansine is an active agent in patients with HER2-mutant lung cancers. This is the first positive trial in this molecular subset of lung cancers. Further use and study of this agent are warranted.
Swift, Ramsay, and “the Cabala, as Masonry Was Call’d in Those Days”
Authors: Schuchard Marsha Keith 
Published: July 2018

Abstract
When Jonathan Swift anonymously published A Letter from the Grand Mistress of the Female Freemasons (Dublin, 1724), he entered a political minefield, for it was a mocking response to James Anderson’s Constitutions of the Freemasons (London, 1723). Swift countered Anderson’s “modern,” Anglocentric, pro-Hanoverian history with his account of more “ancient” Scots-Irish traditions. He drew on his Masonic experiences in Dublin in 1688 and Ulster in 1695, where he learned of the Solomonic, Cabalistic, and Lullist themes of early Stuart Masonry. From his readings in Rosicrucian and Cabalistic works, he developed a “drolling” technique of linguistic and allegorical satire that protected him from government prosecution. Though he was not a practitioner of the esoteric Masonic rituals, his great admirer, Chevalier Andrew Michael Ramsay, determined to implement them in Écossais lodges maintained by exiled Jacobites.
Habilidades Sociais e Comorbidades Psiquiátricas de Mulheres Usuárias de Crack
Authors: Limberger Jéssica , Andretta Ilana 
Published: July 2018

A literatura aponta que características clínicas como a depressão relacionam-se com baixas habilidades sociais. Em mulheres usuárias de crack, tais questões ainda são pouco estudadas. Este estudo objetiva identificar as associações entre habilidades sociais e comorbidades psiquiátricas dessa população. Trata-se de um estudo transversal, quantitativo e correlacional, sendo utilizados como instrumentos: questionário de dados sociodemográficos e de uso de drogas, MINI (Mini International Neuropsychiatric Interview), Inventário de Habilidades Sociais (IHS-Del Prette), Screening Cognitivo do WAIS-III e SCID-II (Structured Clinical Interview for DSM Disorders). Participaram 62 mulheres em internação hospitalar, com média de idade de 33,45 anos (DP=8,14). Mulheres com Episódio Depressivo Maior apresentaram escores significativamente menores no autocontrole da agressividade. Além disso, houve associação entre déficits em habilidades sociais e Transtorno de Personalidade Borderline. Evidencia-se a necessidade de considerar as comorbidades psiquiátricas como um dos fatores que prejudicam o uso das habilidades sociais. Intervenções como o Treinamento em Habilidades Sociais devem ser planejadas a partir de tais comorbidades.
O desafio das competências no serviço público: contribuições teóricas
Authors: Sousa Claudete Francisco de , Muniz Hélder Pordeus 
Published: July 2018

Este artigo propõe uma discussão teórica sobre competências no serviço público a partir da perspectiva ergológica e segundo a contribuição sociológica de Zarifian. A ergologia enfatiza a importância de se criticar a simplificação das mensurações das competências sugerindo uma abordagem do agir em competência com base em ingredientes. Zarifian apresenta o conceito de relação de serviço entendido como uma transformação nas condições de atividade do usuário mediante suas necessidades. Ambas as abordagens envolvem a necessidade de uma gestão de competências centrada no ponto de vista da atividade e fazem a crítica de um gerenciamento que exclua os trabalhadores das decisões sobre o seu trabalho.
As representações parentais em crianças institucionalizadas filhos de usuária de crack
Authors: Both Luciane Maria , Benetti Sílvia Pereira da Cruz 
Published: July 2018

O uso do crack pelos pais é o principal motivo de acolhimento institucional infantil e afeta as representações mentais das figuras parentais. Entretanto, são precários estudos com essa problemática. Assim, este estudo investigou as representações mentais de crianças institucionalizadas filhos de usuária de crack. Trata-se de uma pesquisa qualitativa com três crianças institucionalizadas da mesma família. Instrumentos utilizados: MacArthur Narrative Coding Manual (MSSB), Child Behavior Checklist (CBCL), desenho da família e investigada história familiar. Observaram-se comportamentos e emoções prejudiciais que indicam um ambiente desestruturado para o desenvolvimento mental das crianças. Destaca-se a negligência de cuidados e afetos, ocasionando representações mentais negativas. Verificou-se que as figuras de cuidado foram apresentadas como punitivas, disciplinadoras e ineficazes. Ressalta-se que a compreensão das representações parentais auxilia no entendimento das conflitivas infantis, planejamento da intervenção, mudança terapêutica e ações preventivas.
An update on local anaesthesia in orthodontics
Authors: Harris Lydia MJ , Grewal Sukhraj , Puryer James , Naish Hywel , Sandy Jonathan R , Ireland Anthony J 
Published: July 2018

Abstract: With the increasing use of temporary anchorage devices in orthodontics the use of topical and local anaesthesia is becoming more common in everyday practice. The mode of action, types of anaesthetic and the potential local and systemic complications will be described. CPD/Clinical Relevance: A knowledge of local anaesthetics is essential for any orthodontist, particularly with the increasing popularity of the use of temporary anchorage devices.