bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial validation and results of the Symptoms in Persons At Risk of Rheumatoid Arthritis (SPARRA) questionnaire: a EULAR project
Authors: van Beers-Tas Marian H , ter Wee Marieke M , van Tuyl Lilian H , Maat Bertha , Hoogland Wijnanda , Hensvold Aase H , Catrina Anca I , Mosor Erika , Stamm Tanja A , Finckh Axel , Courvoisier Delphine S , Filer Andrew , Sahbudin Ilfita , Stack Rebecca J , Raza Karim , van Schaardenburg Dirkjan 
Published: May 2018

ObjectivesTo describe the development and assess the psychometric properties of the novel ‘Symptoms in Persons At Risk of Rheumatoid Arthritis’ (SPARRA) questionnaire in individuals at risk of rheumatoid arthritis (RA) and to quantify their symptoms.MethodsThe questionnaire items were derived from a qualitative study in patients with seropositive arthralgia. The questionnaire was administered to 219 individuals at risk of RA on the basis of symptoms or autoantibody positivity: 74% rheumatoid factor and/or anticitrullinated protein antibodies positive, 26% seronegative. Validity, reliability and responsiveness were assessed. Eighteen first degree relatives (FDR) of patients with RA were used for comparison.ResultsFace and content validity were high. The test-retest showed good agreement and reliability (1 week and 6 months). Overall, construct validity was low to moderate, with higher values for concurrent validity, suggesting that some questions reflect symptom content not captured with regular Visual Analogue Scale pain/well-being. Responsiveness was low (small subgroup). Finally, the burden of symptoms in both seronegative and seropositive at risk individuals was high, with pain, stiffness and fatigue being the most common ones with a major impact on daily functioning. The FDR cohort (mostly healthy individuals) showed a lower burden of symptoms; however, the distribution of symptoms was similar.ConclusionsThe SPARRA questionnaire has good psychometric properties and can add information to currently available clinical measures in individuals at risk of RA. The studied group had a high burden and impact of symptoms. Future studies should evaluate whether SPARRA data can improve the prediction of RA in at risk individuals.
Rheological inheritance: lessons from the Death Valley region, US Basin and Range Province
Authors: Lima Rodrigo D. , Hayman Nicholas W. , Miranda Elena 
Published: May 2018

Abstract

Rheological inheritance occurs when older metamorphic and deformational fabrics impact the mechanics of younger tectonic provinces, such as occurs in extensional provinces developed on sites of previous orogenesis. The Funeral and Black Mountains from the Death Valley region of the US Basin and Range provide the opportunity to study such rheological inheritance. The Funeral Mountains expose shear zones containing high-grade metamorphic fabrics and evidence for synkinematic, decompression-driven melt of Late Cretaceous, orogenic origin. Quartz <
c
>- and [
a
]-axes patterns from the shear zones correlate with high-temperature slip systems. The quartz microstructures were formed via grain-boundary migration, and these are overprinted by high-strain layers of mixed-phase aggregates that underwent grain boundary sliding. Reaction textures from the Funeral Mountains illustrate that much of the fabric development post-dates melting, but locally involved melt–rock reactions. In contrast with the Funeral Mountains, the basement complex in the Black Mountains preserves few peak-metamorphic textures, largely owing to the overprinting by Cenozoic magmatism and deformation. However, local relicts of high-grade deformational fabrics yielding Late Cretaceous-through-Eocene magmatic zircon ages are overprinted by greenschist grade fabrics. Using outcrop and microstructural (including electron backscatter diffraction) observations, and thermodynamic modelling, we detail how segregation of melt products during orogenic partial melting resulted in chemically isolated compositional domains, favouring localization via the formation of fine-grained retrograde fabrics. We propose a conceptual model that builds on our results wherein the heterogeneous distribution of peak, orogenic metamorphic phases and melt products governs lower crustal strength and fabric evolution during extension. The Wilson Cycle may be sensitive to rheological inheritance as the width of continental margins formed during rifting will be sensitive to the fabrics and compositions formed during collision.
Metolachlor dense non-aqueous phase liquid source conditions and plume attenuation in a dolostone water supply aquifer
Authors: Parker Beth L. , Bairos Kenley , Maldaner Carlos H. , Chapman Steven W. , Turner Christopher M. , Burns Leanne S. , Plett James , Carter Raymond , Cherry John A. 
Published: May 2018

Abstract

This paper reports a long-term field investigation of a fractured dolostone aquifer that was penetrated by a dense non-aqueous phase liquid. High-resolution source zone characterization shows the evolution of deep penetration to the back-diffusion conditions seen at the present day. Metolachlor, a common herbicide, was released into the overburden overlying a fractured dolostone aquifer within a short time window (1978–81). In 2000, the plume front arrived at a municipal supply well located 930 m down-gradient, increasing to a maximum concentration of 2 μg l
−1
. Groundwater monitoring with high-resolution, depth-discrete multi-level sampling systems since 1992 shows a clearly delineated bedrock plume. Numerous rock core samples show metolachlor in the low-permeability rock matrix at the bottom of the aquifer. The mass distribution and bedrock hydraulic head pattern strongly suggest that metolachlor entered the bedrock as a free-phase dense non-aqueous phase liquid penetrating to the aquifer bottom, preferentially accumulating in some horizontal fractures, dissolving quickly as a result of the rapid groundwater flow and then diffusing into the rock matrix, where back-diffusion sustains a dilute, persistent and stable plume. Strong plume retardation by matrix diffusion and sorption has greatly mitigated the impact on water quality in the down-gradient supply well, allowing for its continued use, while back-diffusion and degradation maintain a persistent, dilute plume managed by appropriate monitoring.
Molecular Subtype-Specific Immunocompetent Models of High-Grade Urothelial Carcinoma Reveal Differential Neoantigen Expression and Response to Immunotherapy
Authors: Saito Ryoichi , Smith Christof C. , Utsumi Takanobu , Bixby Lisa M. , Kardos Jordan , Wobker Sara E. , Stewart Kyle G. , Chai Shengjie , Manocha Ujjawal , Byrd Kevin M. , Damrauer Jeffrey S. , Williams Scott E. , Vincent Benjamin G. , Kim William Y. 
Published: May 2018

Abstract
High-grade urothelial cancer contains intrinsic molecular subtypes that exhibit differences in underlying tumor biology and can be divided into luminal-like and basal-like subtypes. We describe here the first subtype-specific murine models of bladder cancer and show that Upk3a-CreERT2; Trp53L/L; PtenL/L; Rosa26LSL-Luc (UPPL, luminal-like) and BBN (basal-like) tumors are more faithful to human bladder cancer than the widely used MB49 cells. Following engraftment into immunocompetent C57BL/6 mice, BBN tumors were more responsive to PD-1 inhibition than UPPL tumors. Responding tumors within the BBN model showed differences in immune microenvironment composition, including increased ratios of CD8+:CD4+ and memory:regulatory T cells. Finally, we predicted and confirmed immunogenicity of tumor neoantigens in each model. These UPPL and BBN models will be a valuable resource for future studies examining bladder cancer biology and immunotherapy.
Significance: This work establishes human-relevant mouse models of bladder cancer. Cancer Res; 78(14); 3954–68. ©2018 AACR.
Prognostic Roles of Perioperative Body Mass Index and Weight Loss in the Long-Term Survival of Gastric Cancer Patients
Authors: Park Young Suk , Park Do Joong , Lee Yoontaek , Park Ki Bum , Min Sa-Hong , Ahn Sang-Hoon , Kim Hyung-Ho 
Published: May 2018

Abstract
Background: Most patients with gastric cancer rapidly lose weight after gastrectomy. Therefore, analysis of the effect of body mass index (BMI) on patients with gastric cancer survival should include postoperative BMI and BMI loss and preoperative BMI. This retrospective cohort study analyzed the effect of three BMI variables and their interaction on long-term outcomes.
Methods: Preoperative BMI analysis included 2,063 patients with gastric cancer who underwent curative gastrectomy between January 2009 and December 2013 at Seoul National University Bundang Hospital. BMI at postoperative 6 to 12 months was available in 1,845 of these cases.
Results: Patients with preoperative BMI 23.0 to &lt;27.5 [HR, 0.63; 95% confidence interval (CI), 0.48–0.82 for BMI 23.0 to &lt;25.0 and HR, 0.57; 95% CI, 0.42–0.78 for BMI 25.0 to &lt;27.5] and postoperative BMI 23.0 to &lt;25.0 (HR, 0.67; 95% CI, 0.46–0.98) showed significantly better overall survival (OS) than pre- and postoperative patients with BMI 18.5 to &lt;23.0, respectively. Postoperative underweight (BMI &lt;18.5; HR, 1.74; 95% CI, 1.27–2.37) and postoperative severe BMI loss (&gt;4.5; HR, 1.79; 95% CI, 1.29–2.50) were associated with higher mortality. Severe BMI loss and preoperative BMI &lt;23.0 had an adverse synergistic effect; patients with BMI &lt;23.0 were more vulnerable to severe BMI loss than those with BMI ≥23.0. Associations with cancer-specific survival were similar.
Conclusions: All three BMI variables were prognostic factors for survival of patients with gastric cancer. Preoperative BMI and severe BMI loss had an interaction.
Impact: Perioperative BMI and weight loss should be analyzed collectively in patients with gastric cancer undergoing gastrectomy. Cancer Epidemiol Biomarkers Prev; 27(8); 955–62. ©2018 AACR.
SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer
Authors: Audet-Walsh Étienne , Vernier Mathieu , Yee Tracey , Laflamme Chloé , Li Susan , Chen Yonghong , Giguère Vincent 
Published: May 2018

Abstract
Reprogramming of cellular metabolism is an important feature of prostate cancer, including altered lipid metabolism. Recently, it was observed that the nuclear fraction of mTOR is essential for the androgen-mediated metabolic reprogramming of prostate cancer cells. Herein, it is demonstrated that the androgen receptor (AR) and mTOR bind to regulatory regions of sterol regulatory element-binding transcription factor 1 (SREBF1) to control its expression, whereas dual activation of these signaling pathways also promotes SREBF1 cleavage and its translocation to the nucleus. Consequently, SREBF1 recruitment to regulatory regions of its target genes is induced upon treatment with the synthetic androgen R1881, an effect abrogated upon inhibition of the mTOR signaling pathway. In turn, pharmacologic and genetic inhibition of SREBF1 activity impairs the androgen-mediated induction of the key lipogenic genes fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD1). Consistent with these observations, the expression of the SREBF1, FASN, and SCD1 genes is significantly correlated in human prostate cancer tumor clinical specimens. Functionally, blockade of SREBF1 activity reduces the androgen-driven lipid accumulation. Interestingly, decreased triglyceride accumulation observed upon SREBF1 inhibition is paralleled by an increase in mitochondrial respiration, indicating a potential rewiring of citrate metabolism in prostate cancer cells. Altogether, these data define an AR/mTOR nuclear axis, in the context of prostate cancer, as a novel pathway regulating SREBF1 activity and citrate metabolism.
Implications: The finding that an AR/mTOR complex promotes SREBF1 expression and activity enhances our understanding of the metabolic adaptation necessary for prostate cancer cell growth and suggests novel therapeutic approaches to target metabolic vulnerabilities in tumors. Mol Cancer Res; 16(9); 1396–405. ©2018 AACR.
Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers
Authors: Remo Andrea , Manfrin Erminia , Parcesepe Pietro , Ferrarini Alberto , Han Hye Seung , Mickys Ugnius , Laudanna Carmelo , Simbolo Michele , Malanga Donatella , Oliveira Duarte Mendes , Baritono Elisabetta , Colangelo Tommaso , Sabatino Lina , Giuliani Jacopo , Molinari Enrico , Garonzi Marianna , Xumerle Luciano , Delledonne Massimo , Giordano Guido , Ghimenton Claudio , Lonardo Fortunato , D'angelo Fulvio , Grillo Federica , Mastracci Luca , Viglietto Giuseppe , Ceccarelli Michele , Colantuoni Vittorio , Scarpa Aldo , Pancione Massimo 
Published: May 2018

Abstract
Centrosome anomalies contribute to tumorigenesis, but it remains unclear how they are generated in lethal cancer phenotypes. Here, it is demonstrated that human microsatellite instable (MSI) and BRAFV600E-mutant colorectal cancers with a lethal rhabdoid phenotype are characterized by inactivation of centrosomal functions. A splice site mutation that causes an unbalanced dosage of rootletin (CROCC), a centrosome linker component required for centrosome cohesion and separation at the chromosome 1p36.13 locus, resulted in abnormally shaped centrosomes in rhabdoid cells from human colon tissues. Notably, deleterious deletions at 1p36.13 were recurrent in a subgroup of BRAFV600E-mutant and microsatellite stable (MSS) rhabdoid colorectal cancers, but not in classical colorectal cancer or pediatric rhabdoid tumors. Interfering with CROCC expression in near-diploid BRAFV600E-mutant/MSI colon cancer cells disrupts bipolar mitotic spindle architecture, promotes tetraploid segregation errors, resulting in a highly aggressive rhabdoid-like phenotype in vitro. Restoring near-wild-type levels of CROCC in a metastatic model harboring 1p36.13 deletion results in correction of centrosome segregation errors and cell death, revealing a mechanism of tolerance to mitotic errors and tetraploidization promoted by deleterious 1p36.13 loss. Accordingly, cancer cells lacking 1p36.13 display far greater sensitivity to centrosome spindle pole stabilizing agents in vitro. These data shed light on a previously unknown link between centrosome cohesion defects and lethal cancer phenotypes providing new insight into pathways underlying genome instability.
Implications: Mis-segregation of chromosomes is a prominent feature of chromosome instability and intratumoral heterogeneity recurrent in metastatic tumors for which the molecular basis is unknown. This study provides insight into the mechanism by which defects in rootletin, a centrosome linker component causes tetraploid segregation errors and phenotypic transition to a clinically devastating form of malignant rhabdoid tumor. Mol Cancer Res; 16(9); 1385–95. ©2018 AACR.
EvoluSon: Walking through an Interactive History of Music
Authors: Gaugne Ronan , Nouviale Florian , Rioual Octavia , Chirat Arnaud , Gohon Kevin , Goupil Vincent , Toutirais Martin , Bossis Bruno , Gouranton Valérie 
Published: May 2018

Abstract
The EvoluSon project proposes an immersive experience where the spectator explores an interactive visual and musical representation of the main periods of the history of Western music. The musical content is constituted of original musical compositions based on the theme of Bach’s Art of Fugue to illustrate the eight main musical eras from Antiquity to the contemporary epoch. The EvoluSon project contributes at the same time to the usage of VR for intangible culture representation and to interactive digital art that puts the user at the center of the experience. The EvoluSon project focuses on music through a presentation of the history of Western music, and uses virtual reality to valorize the different pieces through the ages. The user is immersed in a coherent visual and sound environment and can interact with both modalities. This project is the result of collaboration between a computer science research laboratory and a research laboratory on art and music. It was first presented to a public event on science and music organized by the computer science research laboratory.
Recommending Multimedia Information in a Virtual Han Chang’an City Roaming System
Authors: Feng Junmei , Feng Xiaoyi , Deng Liming , Peng Jinye 
Published: May 2018

Abstract
This article presents a roaming system of Han Chang’an City, with both virtual reality (VR) technology and information recommendation technology. Nowadays, some new research issues in the cultural heritage domain can be achieved with the rapid development of VR technology. The ancient site of Han Chang’an City, as one of the most valuable and significant cultural heritages in China, attracts more and more attention around the world. To let more people understand Han Chang’an City and reproduce its beauty, in this article, we propose a virtual roaming system combined with information recommendation technology. First, Unity3D is selected as the three-dimensional platform to design the scenario model of Han Chang’ an City, and the virtual scene is reconstructed with VR technology, according to real historical data; then, the dynamic information recommendation module is designed to recommend hot topic information and personalized information. The former is obtained through web crawlers, including the latest released news related to Han Chang’an City for users. The latter is generated by the proposed hybrid recommendation algorithm, which combines explicit and implicit feedback. The performance of the proposed algorithm is validated on two datasets. Finally, we show some results of our system test. Our proposed system is released online now, and users can wander in the scene any time.
Exploring the Influence of Haptic and Olfactory Cues of a Virtual Donut on Satiation and Eating Behavior
Authors: Li Benjamin J. , Bailenson Jeremy N. 
Published: May 2018

Abstract
Olfactory research in immersive virtual environments (IVEs) have often examined the addition of scent as part of the environment or atmosphere that act as experimental stimuli. There appears to be a lack of research on the influence of virtual foods in IVEs on human satiation. Studies based on situational cues or self-perception theory provide support for the hypothesis that touching and smelling a virtual food item may lead to increased consumption as a result of modeling expected behavior. On the other hand, studies grounded in embodied cognition suggest that satiation may take place as a result of mental simulation that resembles actual consumption behavior. In this preliminary study, we sought to explore the effects of haptic and olfactory cues through virtual food on human satiation and eating behavior. In our study, 101 participants took part in a 2 (touch: present vs absent) × 2 (scent: present vs absent) experiment where they interacted with a donut in an IVE. Findings showed that participants in the touch and scent present conditions ate significantly fewer donuts than those who were not exposed to these cues, and reported higher satiation as compared to their counterparts. However, findings were less clear with respect to participants who received both haptic and olfactory cues. As a whole, results provide preliminary support for satiation effects as a result of sensory simulation.
Observed Variations in Turbulent Mixing Efficiency in the Deep Ocean
Authors: Ijichi Takashi , Hibiya Toshiyuki 
Published: May 2018

AbstractRecent progress in direct numerical simulations (DNSs) of stratified turbulent flows has led to increasing attention to the validity of the constancy of the dissipation flux coefficient Γ in the Osborn’s eddy diffusivity model. Motivated by lack of observational estimates of Γ, particularly under weakly stratified deep-ocean conditions, this study estimates Γ using deep microstructure profiles collected in various regions of the North Pacific and Southern Oceans. It is shown that Γ is not constant but varies significantly with the Ozmidov/Thorpe scale ratioROTin a fashion similar to that obtained by previous DNS studies. Efficient mixing events with Γ ~O(1) andROT~O(0.1) tend to be frequently observed in the deep ocean (i.e., weak stratification), while moderate mixing events with Γ ~O(0.1) andROT~O(1) tend to be observed in the upper ocean (i.e., strong stratification). The observed negative relationship between Γ andROTis consistent with a simple scalingthat can be derived from classical turbulence theories. In contrast, the observed results exhibit no definite relationships between Γ and the buoyancy Reynolds number Reb, although Rebhas long been thought to be another key parameter that controls Γ.
Capital Accumulation, Asset Price Dynamics and the Macroeconomy
Authors: Basu Moumita , Nag Ranjanendra Narayan 
Published: May 2018

This article develops a dependent economy model of determination of employment and asset prices that integrates the roles of relative prices, expectations and dynamics of capital accumulation. In this model, money wage is rigid which leads to persistence of unemployment. Labour and capital are used as factors of production in the traded sector while the non-traded sector uses labour and imported intermediate inputs. The article examines macroeconomic implications of selective economic reforms for asset price dynamics, growth and employment. The discussion of comparative static exercises shows that not only the effects of different policies are ambiguous but also the short-run and the long-run effects are qualitatively different. For example, tariff liberalization causes the short-run expansions of both traded and non-traded sectors but overtime it may depress the capital stock leading to contraction of both the sectors and an increase in unemployment. The broad message of this article is that the design of macroeconomic policy should not be purely based on considerations of the short-run effects of policy changes. JEL: E22, F13, F41
A Comparison of Domestic Demand and Export-led Growth Strategies for European Transition Economies
Authors: Sağlam Yağmur , Egeli Hüseyin Avni 
Published: May 2018

The relationship between growth and trade has been argued many times in the literature. The topic is still current, dealing with different methodologies and countries by researchers. In this frame to understand the relationship theoretically and empirically better, the topic is examined again with a different approach which is explaining export-led growth (ELG) and domestic-demand-led growth (DLG) strategies comparatively for European transition economies. The annual data for the period between 1990 and 2015 were taken from Data Stream for 16 European (Central and Eastern Europe, Southeastern Europe and Balkans) transition economies and because data include both cross section and time dimension, it is necessary to apply dynamic panel data techniques. Second-generation unit root test (multifactor), Westerlund ECM panel co-integration test and heterogeneous panel causality test are applied, and long-term coefficients are estimated with common correlated effects (CCE) model. According to test results, not only ELG but also DLG strategy is accepted for European transition economies, and the direction of the relationship between growth and trade is bilateral. But the contribution of domestic demand on growth is seven times bigger than net export. The leading countries for ELG strategy are Romania, Bosnia and Herzegovina but for Poland and Czech Republic DLG strategy contributes more on economic growth. It is a better macroeconomic policy to have the balance between export-led and domestic-demand-led growth strategies for a sustainable economic growth. The key approach of high growth rate is to produce high technology with competitive price according to domestic demand and export it to the foreigner markets. JEL Codes: F14, C01, C33