bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Massive Religious Festival Celebrations Encourage a Faster Spread of a Pandemic? The Case of COVID-19 in Israel
Authors: Estrada Mario Arturo Ruiz , Levy Inna 
Published: November 2024

Abstract
This paper attempts to evaluate how massive religious festival celebrations can encourage the faster spread of any pandemic according to our problem statement, such as the case of COVID-19. For example, we evaluate Israel’s three major religions, namely Judaism, Christianity, and the Islamic festival celebrations, respectively. Firstly, we have the traditional Jewish festivities such as Hanukkah, Yom Kippur, Sukkot, and Rosh Hashanah. In the Christian’s traditional festivities celebrations, we identified Christmas, Easter Day, and All Saints Day. Finally, the Muslim festivities of Muharram and the Birthday of the Holy Prophet Mohamad. The purpose of this study was to evaluate if these nine massive religious festival celebrations are the main reasons for the large spread of COVID-19 in Israel directly or indirectly. In fact, we propose a new methodology to evaluate the impact of any massive religious festival celebration and the fast spread of any pandemic everywhere and anytime. The new indicator is entitled “The National Spread Levels of Infectious Diseases Risk from Massive Religious Festivities Index” (National-SLIDRMRF-Index). Finally, the major finding in this research is that any massive religious events can generate an exponential number of COVID-19 cases constantly. Therefore, this research concluded that we urgently need a standardized index to monitor and control the expansion of any pandemic such as COVID-19 among different religious groups in the same country. At the same time, we give different policy recommendations to the Israeli government to constantly keep major controls and measures of different religious events in Jerusalem.
Spiritual and Emotional Care Among Clergy as First Responder–Victims in Puerto Rico: A Longitudinal Qualitative Study
Authors: Bryant Julianne , Nyhof Melanie , Hassler Michael W. , Abe Jennifer , Vives De León Anthony 
Published: November 2024

AbstractA longitudinal qualitative study was conducted to explore the experiences of church leaders (10 priests, pastors, and pastors’ wives) who provided disaster spiritual/emotional care (DSEC) to the island of Puerto Rico during a period of intense and repeated crises from 2017 to 2022. Utilizing a narrative inquiry approach, 18 in-depth interviews were conducted and analyzed. Findings indicated that the participants engaged in psychological, social, and religious coping strategies to actively cope with the stress and trauma of being first responder rescuer/victims. Regional, cultural and contextual factors are considered in an effort to understand and enhance services to populations where disaster is the new normal.
Soil cover heterogeneity associated with biocrusts predicts patch-level plant diversity patterns
Authors: Havrilla Caroline A. , Villarreal Miguel L. 
Published: November 2024

Abstract
Context
Soil resource heterogeneity drives plant species diversity patterns at local and landscape scales. In drylands, biocrusts are patchily distributed and contribute to soil resource heterogeneity important for plant establishment and growth. Yet, we have a limited understanding of how such heterogeneity may relate to patterns of plant diversity and community structure.

Objectives
We explored relationships between biocrust-associated soil cover heterogeneity and plant diversity patterns in a cool desert ecosystem. We asked: (1) does biocrust-associated soil cover heterogeneity predict plant diversity and community composition? and (2) can we use high-resolution remote sensing data to calculate soil cover heterogeneity metrics that could be used to extrapolate these patterns across landscapes?

Methods
We tested associations among field-based measures of plant diversity and soil cover heterogeneity. We then used a Support Vector Machine classification to map soil, plant and biocrust cover from sub-centimeter resolution Unoccupied Aerial System (UAS) imagery and compared the mapped results to field-based measures.

Results
Field-based soil cover heterogeneity and biocrust cover were positively associated with plant diversity and predicted community composition. The accuracy of UAS-mapped soil cover classes varied across sites due to variation in timing and quality of image collections, but the overall results suggest that UAS are a promising data source for generating detailed, spatially explicit soil cover heterogeneity metrics.

Conclusions
Results improve understanding of relationships between biocrust-associated soil cover heterogeneity and plant diversity and highlight the promise of high-resolution UAS data to extrapolate these patterns over larger landscapes which could improve conservation planning and predictions of dryland responses to soil degradation under global change.
Approach to the patient with controlled acromegaly and acromegalic arthropathy: clinical diagnosis and management
Authors: Pelsma Iris C. M. , Kroon Herman M. , Andela Cornelie D. , van der Linden Enrike M. J. , Kloppenburg Margreet , Biermasz Nienke R. , Claessen Kim M. J. A. 
Published: November 2024

AbstractFollowing the description of an illustrative case of a 70-year-old female patient with longstanding active acromegaly and invalidating, progressive joint complaints, current insights regarding diagnosis, treatment, and long-term management of acromegalic arthropathy are summarized. Since clinical trials on this topic are lacking, the reported recommendations are based on extensive clinical and research experience with this clinical entity, and on established diagnostics and interventions in patients with other rheumatic diseases. The cornerstones of the management of acromegalic arthropathy remains normalization of growth hormone and insulin growth factor-1 levels. However, patients with severe or progressive acromegalic arthropathy require a multidisciplinary approach to determine adequate diagnostics and treatment options. Because of the high prevalence and invalidating character of acromegalic arthropathy, developing evidence-based effective prevention and treatment strategies, preferably by international collaboration within rare disease networks, e.g., Endo-ERN, is a clear unmet need.
The Ether Concept from Spanish Physics Textbooks (1840–1950)
Authors: Vaquero-Martínez J. , Vaquero J. M. 
Published: October 2024

AbstractThe presence of the ether concept in the contents of 73 Spanish physics textbooks (secondary and first course university level) published in the period 1840–1950 is studied. The textbooks are a specially interesting learning tool in the Spanish society of this period, due to the rural character of the country, the capacity of the textbooks for frequent and repeated use as well as for dissemination over the entire state. Particularly, the content about heat, light and electricity is investigated. Whether the concept of ether appears in the general principles of the textbooks or not is also studied. Moreover, the work considers the evolution of the concept of ether by decades, showing different examples of how the ether was used to explain different physics phenomena. Furthermore, the social and historical context in which the textbooks were developed is discussed in detail. Outstanding amongst the different conclusions that are drawn is the disappearance of the concept of the ether during the third and fourth decades of the twentieth century.
Examining the use of drug screening technologies in night-time entertainment districts
Authors: Hughes Lee R. J. , Sorbello Jacob G. , Piron Kurt , Allen Corey , Piatkowski Timothy , Devilly Grant J. 
Published: November 2024

Abstract
Background
We sought to determine whether various ion scanner devices could provide a practical alternative in field-based research, where affordable and accessible drug screening is needed for comprehensive and ongoing investigation.

Methods
In Study 1, off-site sample analysis proved inconclusive, rendering Protocols A and B impractical for ongoing drug screening. Conversely, Study 2’s on-site, real-time analysis (Protocol C) emerged as a more effective method. The Itemizer3, particularly in Protocol C, excelled in discerning drug users. Comparing admitted drug use rates in both studies, the mere presence of an objective measure, confirmational or not, likely facilitated more truthful participant responses, highlighting the efficacy of real-time, on-site drug screening using IMS/ITMS technologies.

Findings
All samples analyzed off-site in Study 1 were found to be inconclusive. As such, Protocols A and B were not feasible for on-going drug screening and monitoring. Conversely, the results of Study 2 Protocol C demonstrated that harvesting samples directly off participants on-site and analyzing these in-real time to be a more efficacious method. Our findings in Protocol C also show that the Itemizer3 was better at identifying those who did not use drugs from those who did. Looking at the incidence rates of admitted drug use in Studies 1 and 2, we find that simply having an objective measure present (irrespective of whether it is confirmational or not) likely resulted in us obtaining more truthful responses from participants about their use of drugs.

Conclusions
Our results underscore IMS/ITMS practicality for on-site NED drug screening.
A Parallel Mediator Model to Explain the Organizational Performance Oriented to the Quality of Life of People with Intellectual Disabilities: The Employees and Family Members Perspectives
Authors: Estreder Yolanda , Sadi Maimoona Wasif , Martínez-Tur Vicente , Zappalà Salvatore , Moliner Carolina 
Published: November 2024

AbstractThis research examines whether employees’ perceptions of service climate are related to organizational performance oriented toward improving the quality of life (QoL) of people with intellectual disability (ID) through the mediation of service quality perceived by family members. The research was conducted in 252 centers for people with ID in Spain. Employees (N = 2.021) reported on service climate. Family members (N = 2.267) reported on service quality and organizational performance oriented toward improving QoL. We used an overall measure of service climate. Service quality was composed of two dimensions: functional (efficiency in the delivery of the core service) and relational (quality of the social interaction between employees and service users beyond the core service) service quality. Organizational performance oriented toward QoL was composed of four dimensions: overall QoL; self-determination; social inclusion; and defense of rights of people with ID. Results supported full mediation, with functional and relational service quality mediating the relationship between service climate and performance oriented toward improving QoL. Implications for research and organizations are also discussed.
Genome sequences for twenty-four Phytophthora and one Nothophytophthora species for the study of the evolution of pathogenicity in Peronosporaceae
Authors: Ulaszewski Bartosz , Mishra Bagdevi , Jung Thomas , Thines Marco 
Published: October 2024

AbstractOomycetes classified in the genera Phytophthora and Nothophytophthora encompass a wide range of lifestyles, from saprotrophic and water-borne to destructive soil-borne or wind-dispersed plant pathogens. To clarify the evolutionary and genomic basis of these transitions, genome sequences for a wide range of species are necessary. However, the amount of genomes currently available is not representative of the full range of these lifestyles. To address this gap, we present draft genomes of 24 Phytophthora and one Nothophytophthora species, of which 14 have 100% BUSCO completeness for the Straminipila dataset. We hope that this resource will stimulate further research into the evolution of pathogenicity in Peronosporaceae.
How cooperative mindsets and course climate relate to the perceived impact of digital cooperation on learning in higher education
Authors: Jördens Kim A. , Nöth Linnea , Zander Lysann 
Published: November 2024

AbstractThis article in the journal “Gruppe. Interaktion. Organisation. (GIO)” presents the results of a study examining one underlying mechanism of successful digital cooperation among students in higher education from a student perspective. We investigated whether and how students’ cooperative mindset and the climate in their university courses correlate with how they perceive the impact of digital cooperation on their learning outcomes. Data were collected using a questionnaire in different university courses at three universities, involving students from different study programmes and semesters. We conducted a mediation analysis that included students’ cooperative mindsets, the perception of the course climate, and the perception of the impact of digital cooperation on students’ learning outcomes. We found that students’ cooperative mindsets predicted their perception of the impact of digital cooperation on their learning. The cooperative mindset of students also predicted their perception of the course climate, which, in turn, predicted their perception of the impact of digital cooperation on their learning. Moreover, we found that the effect of students’ cooperative mindset on the perceived impact of digital cooperation on learning was mediated by the perception of the course climate. These findings suggest that highlighting the relevance of digital cooperation for learning outcomes can initiate a positive dynamic shaping students’ perceptions of their course climate and benefits of digital cooperation. Understanding these dynamics is crucial because cooperative group work in digital environments has become an integral part of teaching in higher education.
Effect of Compositionally Different Substrates on Elemental Properties of Bay Bolete Mushrooms: Case Study of 34 Essential and Non-essential Elements from Six Areas Affected Differently by Industrial Pollution
Authors: Andronikov Alexandre V. , Andronikova Irina E. , Sebek Ondrej , Martinkova Eva , Stepanova Marketa , Perehon Oksana 
Published: October 2024

AbstractWe studied concentrations of 34 essential and non-essential elements in samples of edible Bay Bolete (Imleria badia) mushrooms added by samples of the growing substrate and bioavailable fraction. The samples were collected from six forested sites affected differently by industrial pollution and underlain by compositionally contrasting bedrock: granite, amphibolite, and peridotite. In all cases, mushrooms behaved as a bioconcentrating system for elements such as Ag, K, P, Rb, S, and Se (BCF > 1) being a bioexcluding system for the rest of the elements analyzed (BCF < 1). Most analyzed elements displayed moderate to high within-mushroom mobility being accumulated preferably in the apical parts of the mushroom’s fruiting body (TF > 1). The highest mobility was demonstrated by Cd and Cu. Sodium was the only element with significantly low mobility (TF < 1), and it accumulated preferably in the stipe. Imleria badia seems to be sensitive to the accumulation of elements such as As, Cd, and Pb from the atmospheric deposits. Specific geochemistry of the growing substrate was reflected to different extend in the accumulation of elements such as Ag, Cu, Rb, S, Al, Ca, Fe, Ba, and Na in the mushroom’s fruiting bodies.
Modulating versatile pathways using a cleavable PEG shell and EGFR-targeted nanoparticles to deliver CRISPR-Cas9 and docetaxel for triple-negative breast cancer inhibition
Authors: Lo Yu-Li , Hong Ci-Jheng , Wang Chen-Shen , Yang Ching-Ping 
Published: November 2024

AbstractHuman antigen R (HuR), an RNA-binding protein, is implicated in regulating mRNA stability and translation in cancer, especially in triple-negative breast cancer (TNBC), a highly aggressive form. CRISPR/Cas9-mediated HuR knockout (HuR CRISPR) presents a promising genetic therapeutic approach, but it encounters transfection limitations. Docetaxel (DTX), an effective cytotoxic agent against metastatic breast cancer (BC), faces challenges related to vehicle-associated adverse events in DTX formulations. Therefore, we designed multifunctional nanoparticles with pH-sensitive PEG derivatives and targeting peptides to enable efficient HuR CRISPR and DTX delivery to human TNBC MDA-MB-231 cells and tumor-bearing mice. Our findings indicated that these nanoparticles displayed pH-responsive cytotoxicity, precise EGFR targeting, efficient tumor penetration, successful endosomal escape, and accurate nuclear and cytoplasmic localization. They also demonstrated the ability to spare normal cells and prevent hemolysis. Our study concurrently modulated multiple pathways, including EGFR, Wnt/β-catenin, MDR, and EMT, through the regulation of EGFR/PI3K/AKT, HuR/galectin-3/GSK-3β/β-catenin, and P-gp/MRPs/BCRP, as well as YAP1/TGF-β/ZEB1/Slug/MMPs. The combined treatment arrested the cell cycle at the G2 phase and inhibited EMT, effectively impeding tumor progression. Tissue distribution, biochemical assays, and histological staining revealed the enhanced safety profile of pH-responsive PEG- and peptide-modified nanoformulations in TNBC mice. The DTX-embedded and peptide-modified nanoparticles mitigated the side effects of DTX, enhanced cytotoxicity in TNBC MDA-MB-231 cells, and exhibited remarkable antitumor efficacy and safety in TNBC-bearing mice with HuR CRISPR deletion. Collectively, the combination therapy of DTX and CRISPR/Cas9 offers an effective platform for delivering antineoplastic agents and gene-editing systems to combat tumor resistance and progression in TNBC.
Rational development of fingolimod nano-embedded microparticles as nose-to-brain neuroprotective therapy for ischemic stroke
Authors: Zhang Xinyue , Su Guangpu , Shao Zitong , Chan Ho Wan , Li Si , Chow Stephanie , Tsang Chi Kwan , Chow Shing Fung 
Published: November 2024

AbstractIschemic stroke is one of the major diseases causing varying degrees of dysfunction and disability worldwide. The current management of ischemic stroke poses significant challenges due to short therapeutic windows and limited efficacy, highlighting the pressing need for novel neuroprotective treatment strategies. Previous studies have shown that fingolimod (FIN) is a promising neuroprotective drug. Here, we report the rational development of FIN nano-embedded nasal powders using full factorial design experiments, aiming to provide rapid neuroprotection after ischemic stroke. Flash nanoprecipitation was employed to produce FIN nanosuspensions with the aid of polyvinylpyrrolidone and cholesterol as stabilizers. The optimized nanosuspension (particle size = 134.0 ± 0.6 nm, PDI = 0.179 ± 0.021, physical stability = 72 ± 0 h, and encapsulation efficiency of FIN = 90.67 ± 0.08%) was subsequently spray-dried into a dry powder, which exhibited excellent redispersibility (RdI = 1.09 ± 0.04) and satisfactory drug deposition in the olfactory region using a customized 3D-printed nasal cast (45.4%) and an Alberta Idealized Nasal Inlet model (8.6%) at 15 L/min. The safety of the optimized FIN nano-embedded dry powder was confirmed in cytotoxicity studies with nasal (RPMI 2650 and Calu-3 cells) and brain related cells (SH-SY5Y and PC 12 cells), while the neuroprotective effects were demonstrated by observed behavioral improvements and reduced cerebral infarct size in a middle cerebral artery occlusion mouse stroke model. The neuroprotective effect was further evidenced by increased expression of anti-apoptotic protein BCL-2 and decreased expression of pro-apoptotic proteins CC3 and BAX in brain peri-infarct tissues. Our findings highlight the potential of nasal delivery of FIN nano-embedded dry powder as a rapid neuroprotective treatment strategy for acute ischemic stroke.
Graphical abstract
Effect of enzymatic chemo-mechanical agents on adhesion of composite resin to dentin of permanent teeth: an in vitro study
Authors: Coelho A. S. , Vilhena L. , Amaro I. , Melo A. , Paula A. , Marto C. M. , Ferreira M. M. , Ramalho A. , Carrilho E. 
Published: November 2024

Abstract

Purpose
To evaluate and compare the effect of two enzymatic chemo-mechanical caries removal agents with conventional caries removal using rotatory instruments on the adhesion of composite resin to dentin of permanent teeth.

Methods
The sample comprised 30 permanent molars with caries lesions extending to the dentin, randomly distributed into three groups (n = 10 each): 1—Caries removal with rotary instruments (control group); 2—Caries removal with Papacárie Duo® (F&A Laboratório Farmacêutico, São Paulo, Brazil); 3—Caries removal with Brix 3000™ (Brix S.R.L., Carcarañá, Argentina). After caries removal, the specimens were rinsed and dried. Scotchbond Universal™ adhesive (3 M, Saint Paul, Minnesota, USA) was actively applied in self-etch mode and light-cured. Resin composite increments were applied using a silicone mold (3 × 3 × 2 mm) and light-cured. Shear bond strength (MPa), work-to-debonding (J/m2), and shear modulus (kPa) were evaluated. For statistical analysis, the level of significance was set at 5%.

Results
The control group presented significantly higher shear bond strength values (8.50 ± 2.69 MPa) compared to the Brix 3000™ group (5.72 ± 1.55 MPa, p = 0.008). There were no significant differences between Papacárie Duo® (6.66 ± 0.86 MPa) and the other groups (p > 0.05). Regarding work-to-debonding, the Papacárie Duo® group had a significantly higher result (2944.41 ± 450.21 J/m2) than the Brix 3000™ group (1189.41 ± 504.13 J/m2, p < 0.001) and the control group (967.10 ± 270.01 J/m2, p < 0.001). Concerning shear modulus, the control group showed a significantly higher result (558.67 ± 168.96 kPa) than the Brix 3000™ group (339.79 ± 143.78 kPa, p = 0.008) and the Papacárie Duo® group (223.04 ± 127.30 kPa, p < 0.001).

Conclusion
While the application of Papacárie Duo® did not negatively affect composite resin adhesion to dentin of permanent teeth, the application of Brix 3000™ reduced adhesive forces, potentially limiting its clinical use. Further investigations are warranted to elucidate the effects of these materials on dentin substrate, particularly through clinical studies.
On the virtually cyclic dimension of normally poly-free groups
Authors: Jiménez Rolland Rita , León Álvarez Porfirio L. 
Published: November 2024

AbstractIn this note we give an upper bound for the virtually cyclic dimension of any normally poly-free group in terms of its length. In particular, this implies that virtually even Artin groups of FC-type admit a finite-dimensional model for the classifying space with respect to the family of virtually cyclic subgroups.