bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of voluntary medical insurance in the Russian Federation
Authors: Arsentyev E V 
Published: October 2019

Aim. To analyze the dynamics of the development of voluntary medical insurance in the Russian Federation. To identify the factors hindering the development of this insurance sector in modern conditions.
Methods. In the course of the study, analysis was conducted of the legislative framework for organizing medical care for the population of the Russian Federation in the system of voluntary medical insurance. The problem-chronological, systematic, and analytical research methods were used.
Results. It has been established that, despite the development of voluntary medical insurance system over the past 25 years, the availability of this type of insurance for citizens of the Russian Federation still remains very low. The policy of voluntary medical insurance is mainly available only to working citizens, and only in those large enterprises where the employer is interested in preserving and protecting the health of its employees. For most citizens of the Russian Federation, the voluntary health insurance policy remains inaccessible due to the high cost of the policy, as well as due to relatively low incomes. At the same time, a voluntary health insurance policy is required by law for labor migrants to obtain a patent for employment in the Russian Federation. However due to the absence of legislative framework for voluntary health insurance, organization of medical care for labor migrants is not always standardized.
Conclusion. For the further development of voluntary medical insurance, it is necessary to develop the measures for decreasing the cost and increasing the availability of a voluntary medical insurance policy for citizens of the Russian Federation; to optimize organization of health care for labor migrants it is necessary to primarily develop regulatory framework of emergency health care.
Efficacy and safety of endovascular image-guided treatment of pseudoaneurysms of the celiac artery: clinical and organizational aspects
Authors: Goloshchapov-Aksenov R S , Kicha D I , Frolov S K , Gurin A V 
Published: October 2019

Aim. To present the immediate results of the assessment of the effectiveness and safety of the use of endovascular technologies for the treatment of hemorrhagic complications of pseudoaneurysms of the visceral branches of the abdominal aorta, to offer organizational technologies for the provision of medical care to patients with gastrointestinal bleeding associated with pseudoaneurysms of the visceral arteries.
Methods. Endovascular image-guided treatment was performed in 12 patients with pseudoaneurysms of the branches of the celiac trunk. Mean age 546.6 years, patients were hospitalized urgently due to ongoing or recurrent gastrointestinal bleeding, severe anemia, with blood hemoglobin level of 80 g/l. The diagnosis of pseudoaneurysm of the visceral artery was established by computed tomography-angiography. The sizes of pseudoaneurysms varied from 12 to 54 mm in diameter. Endovascular surgery was performed on the first day of hospitalization. In all cases, the stent-graft was implanted into the gastrointestinal or splenic artery into pseudoaneurysm ostium. The average follow-up period was 352.2 days.
Results. Endovascular surgery was performed 286.3 hours after making a diagnosis, 2 hours after in-hospital admission. The effectiveness and safety of endovascular treatment was 100% and included stopping the ongoing gastrointestinal bleeding and prevention of its recurrence. Hospital stay of patients was 5 days. The effectiveness stent-graft implantation was confirmed by control angiography. There were no hemorrhagic and embolic complications during follow-up.
Conclusion. Endovascular image-guided treatment and prevention of gastrointestinal bleeding in patients with pseudoaneurysms of the branches of the celiac trunk is an effective and safe method; it is necessary to further improve the organization of endovascular care in order to make it more available to the population and to provide effective care in time in case of development of life-threatening diseases and complications.
Surgical techniques of intraocular lens-capsular bag complex stabilization during cataract phacoemulsification in patients with lens subluxation
Authors: Kopaev S Yu , Il´inskaya I A , Burtseva A A 
Published: October 2019

Aim. To develop and to assess the efficacy of the method of one-step upper fixation of a single-piece intraocular lens to the iris during cataract phacoemulsification in patients with lens subluxation.
Methods. The study included 32 patients (37 eyes) with complicated cataract grade 23 combined with grade 12 lens subluxation. Both groups underwent cataract phacoemulsification with consequent implantation of a capsular tension ring and a single-piece intraocular lens. Group 1 (21 eyes) underwent intraoperative one-step upper haptic fixation of a single-piece intraocular lens in vertical position. In group 2 (16 eyes) in 13 cases 61.5 months later a single piece intraocular lens was repositioned and both haptics were sutured to the iris.
Results. In both groups no intraoperative complications occured. Visual acuity in group 1 on days 13 after the surgery was 0.770.19 and was stable during the follow-up. Intraocular pressure was 17.20.99 mm Hg. In group 2 the obtained good functional results 0.780.18 declined due to intraocular lens decentration, the intraocular pressure increased by 6.01.25 mm Hg (up to 24.20.65 mm Hg) which required an intraocular lens reposition in 81.3% of cases. According to ultrasound biomicroscopy, in both groups intraocular lens in all cases had intracapsular fixation and was in a central position.
Conclusion. The developed method of a one-step single piece intraocular lens fixation by suturing the upper haptic to the iris during cataract phacoemulsification in patients with lens subluxation is an effective and safe procedure that allows complete rehabilitation of patients with phacodonesis during a one-step surgical intervention.
Peripheral blood erythrocytes morphology in ovarian cancer
Authors: Fedotova A Yu , Gening T P , Abakumova T V , Dolgova D R 
Published: October 2019

Aim. To assess the morphology of circulating red blood cells in patients with stage III ovarian cancer.
Methods. The object of the study was the peripheral blood erythrocytes of primary patients with ovarian cancer (n=25) who had stage III according to International Federation of Gynecology and Obstetrics. Patients were examined in the gynecological department of Ulyanovsk Regional Clinical Oncology Center. The control group included 25 somatically healthy women. Morphological studies were performed using light microscopy. The number of red blood cells with an unchanged and altered shape was expressed as a percentage. By the method of atomic force microscopy, the topology and rigidity of red blood cells was studied.
Results. A statistically significant decrease in the number of circulating blood erythrocytes was found in patients with ovarian cancer compared to somatically healthy women. At the same time, the number of discocytes is markedly reduced while the number of morphologically altered forms: echinocytes, stomatocytes, spherocytes and erythrocyte rigidity are increased.
Conclusion. With the appearance of altered forms of red blood cells and increase of the transformation index and erythrocyte rigidity in patients with stage III ovarian cancer, total number of red blood cells decreases in circulating blood compared to somatically healthy women.
Clinical profile and pattern of bacterial isolates from bile aspirates of cholecystectomy patients
Authors: Goel Shewtank , Pandey Pooja Tripathi , Kumar Abhay , Arora Deval Kumar , Kumar Nidhish , Singh Abhishek 
Published: October 2019

Background: Antibiotic policy and appropriate antibiotic prophylaxis cannot be designed unless data is available about bacteria colonizing the bile associated with gall bladder disease. Authors aim was to assess the clinical profile and pattern of bacterial isolates from bile aspirates of cholecystectomy patients seeking care at a tertiary care teaching hospital.Methods: Patients who underwent cholecystectomy for various hepatobiliary ailments during year 2017-18 formed the study population. Bile aspirates were collected during cholecystectomy and sent to the microbiology laboratory. Ultrasonography, computed tomography and MRCP were done to confirm the gall bladder pathology before surgery.Results: Out of total eighty-six patients, bacterial growth was observed in 28 (32.56%) subjects. As per division of bile samples, maximum number of study participants (39.29%) having bactibilia were seen in Group II. Group with second highest number of patients showing bactibilia was Group III with 9 subjects (32.14%). Eight subjects (28.57%) exhibited bacterial growth in bile aspirates in Group I subjects. Three patients (10.71%) showed bile infected with multiple bacteria i.e. polymicrobial infection. The gram-negative preponderance was seen in all the three groups with Escherichia coli being most common in group I and II. Pseudomonas aeruginosa was isolated in majority of the patients in group II and III.Conclusions: It is advised that all patients undergoing cholecystectomy must have their bile aspirated during cholecystectomy and sent for microbiological examination and culture. It will help in choosing appropriate antibiotic to prevent infection.
O CONTROLE DE CONVENCIONALIDADE DIFUSO DE OFÍCIO E A VEDAÇÃO DAS DECISÕES SURPRESA.
Authors: Lins Rocha Matheus , Vianna Alves Ferreira Olavo Augusto , Vidotte Blanco Tarrega Maria Cristina 
Published: October 2019

O controle de convencionalidade é um importante mecanismo utilizado com a finalidade de promover a adequação do ordenamento jurídico brasileiro infraconstitucional aos tratados internacionais de direitos humanos. Ainda pouco utilizado pelos juristas, o controle de convencionalidade em sua modalidade difusa é objeto de estudo no âmbito do processo civil brasileiro. O objetivo deste trabalho é a análise da realização do referido controle diante dos princípios do devido processo legal, do contraditório e da ampla defesa, bem como no que tange às regras e demais princípios elencados no Código de Processo Civil de 2015, dentre elas, sobretudo, a que prevê a vedação das “decisões surpresa” no âmbito processual, elencada no artigo 10 do referido diploma. O método empregado será o dedutivo, a técnica metodológica será a pesquisa teórica, partindo-se da análise das pesquisas bibliográficas, da legislação e da jurisprudência, para a aplicação das proposições e conclusões no caso concreto. Será possível verificar, como resultado, de que forma deve ser realizado o controle de convencionalidade difuso, respeitando-se as normativas processuais do Estado Democrático de Direito.
ADOÇÃO ANIMAL IFC: INCENTIVANDO A ADOÇÃO DE ANIMAIS ABANDONADOS
Authors: Evangelista Alberto Gonçalves , Santos Anna Carolina Rodrigues , Thomsen Isabelle Cristine , Pacheco Gabriel da Silva , Bortoli Karine Nickel , Rybandt Raquel , Marson Erica Perez 
Published: October 2019

O projeto “Adoção Animal IFC” nasceu da iniciativa de acadêmicos do curso de Medicina Veterinária do Instituto Federal Catarinense Campus Araquari. Empregando as mídias digitais, por meio das fan pages “Adoção Animal-IFC”, presentes nas redes sociais Facebook® e Blogger®, além de ações físicas, objetivou promover a adoção de animais que foram abandonados estando provisoriamente em abrigos especializados ou lares temporários. Além do estímulo à adoção, com ênfase aos benefícios mútuos, os recursos metodológicos escolhidos visaram a conscientização das pessoas para a guarda responsável e consequências do abandono. Auxiliando uma Organização Não-Governamental, o Abrigo Animal em Joinville/SC, o projeto, além do veículo digital, inseriu-se no meio físico, promovendo a realização de feiras de adoção e de ações de conscientização. De um total de 83 animais postados nas fan pages, 68 foram adotados, demonstrando que as mídias sociais representam uma importante ferramenta no estímulo às adoções, porém não exime as ações físicas de divulgação. Dados obtidos por meio de um questionário aplicado durante uma ação física revelam que 70% dos entrevistados não conheciam o Abrigo Animal e mais da metade não adotaria um animal por meio das mídias digitais. O projeto Adoção Animal IFC cumpriu um importante papel, inserindo os acadêmicos no exercício da cidadania em prol da comunidade e se diferenciando pela escolha de recursos inovadores e criativos para o estudo do abandono de animais. Novas abordagens são requeridas, uma vez que ainda estamos longe de uma solução efetiva que responsabilize a sociedade e elimine a população de animais nas ruas.
Palavras-Chave: Abandono animal; Guarda responsável; Mídias digitais.
Numerical Simulation of Water Shut-Off for Heterogeneous Composite Oil Reservoirs
Authors: Suleimanov Baghir A. , Feyzullayev Khasay A. 
Published: October 2019

Abstract
The article proposes a mathematical model of water shut-off in a homogeneous and heterogeneous composite horizontal reservoir during the process of two-phase and three-component filtration of fluids with the consideration of capillary phenomena, residual resistance factor, and depth of the water shut-off agent penetration. According to the numerical calculations the residual resistance factor subsequent to water shut-off significantly influences efficiency of the process; moreover, at any stage of field development, significant oil recovery factor increase can be achieved by the residual resistance factor regulation.The depth of the water shut-off agent penetration and the time for its flushing-out are notably depend on the production zone permeability. The proposed model allowstochoosethe best timingfor water shut-off stimulation.
Tumor hypoxia impairs NK cell cytotoxicity through SHP-1-mediated attenuation of STAT3 and ERK signaling pathways
Authors: Wang Yanmeng , Teng Rui , Lv Nan , Williamson Ramone A. , Lei Lei , Fan Rong , Chen Ping , Lei Li , Zhang Yuchen , Wang Baiyan , Peng Yue , Fu Jiaqi , Liu Xuna , He Aili , O’Dwyer Michael , Hu Jinsong 
Published: October 2019

Abstract
Natural killer (NK) cells are innate immune effectors with potent anti-tumor activity. Nonetheless, tumor cells have the ability to create an immunosuppressive microenvironment, thereby escaping from immune surveillance. Although accumulating evidence indicates that microenvironmental hypoxia plays an important role in favoring tumor development and immune evasion, it is still unclear how hypoxia directly impairs NK cell anti-tumor activity. In this study, we confirmed that hypoxic NK cells show significantly lower cytotoxicity against tumor cells. Consistent with this, we also found that the reduction in NK cell cytotoxicity resulting from hypoxia is related to the lower expression of granzyme B, IFN-γ, degranulation marker CD107a, as well as killer activation receptors including NKp30, NKp46, and NKG2D on NK cells. More importantly, we further demonstrated that a reduction in the phosphorylation levels of ERK and STAT3 secondary to hypoxia are tightly associated with the attenuated NK cell cytotoxicity. Focusing on the mechanism responsible for reducing phosphorylation levels of ERK and STAT3, we revealed that the activation of protein tyrosine phosphatase SHP-1 (src homology region 2 domain-containing phosphatase-1) following hypoxia may play an essential role in this process. When knocking down SHP-1 or blocking its activity using a specific inhibitor TPI-1, we were able to partially restore NK cell cytotoxicity under hypoxia. Taken together, we demonstrated that hypoxia can impair NK cell cytotoxicity by decreasing the phosphorylation levels of ERK and STAT3 in a SHP-1 dependent manner. Therefore, targeting SHP-1 could provide an approach to enhance NK cell-based tumor immunotherapy.
Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma: a systematic review and meta-analysis
Authors: Wang Horng-Yuan , Lin Ying-Chun , Chen Chieh-Chang , Chen Ming-Jen , Wu Ming-Shiang , Liu Chun-Jen , Huang Chun-Ta , Yang Horng‐Woei , Shih Shou-Chuan , Yu Lo-Yip , Kuo Yang-Che , Hu Kuang-Chun 
Published: October 2019

Abstract
Background

Helicobacter pylori (H. Pylori) infection and hyperglycemia may be associated with an increased risk of colorectal neoplasm. However these two factors affect colorectal neoplasm remain controversial. We aimed to carry out a meta-analysis to evaluate the study population diabetes prevalence rate and H. pylori infection rate with colorectal adenoma risk.

Methods

We conducted a systemic research through English databases for medical reports. We also recorded the diabetes prevalence and H. pylori infection prevalence in each study. We classified these studies into 4 subgroups as their background population diabetes prevalence < 6%(Group 1); between 6 to 8%(Group 2); between 8 to 10 %(Group 3) and more than 10%(Group 4). The random effects model had used to calculate pooled prevalence estimates with 95% confidence interval [CI].

Results

Twenty seven studies were finally eligible for meta-analysis. The random-effects model of meta-analysis was chosen, showing pooled odds ratio (OR) equal to 1.51 (95 % CI 1.39–1.63). The subgroup meta-analyses showed in Group 1 the H. pylori infection associated colorectal adenoma risk OR was 1.24 (95 % CI 0.86–1.78). As diabetes rate exceed 6%, the H. pylori infection became more significant increased risk of colorectal adenoma (Group 2: OR 2.16 (95 % CI 1.61–2.91); Group 3: OR 1.40 (95 % CI 1.24–1.57); Group 4: OR 1.52 (95 % CI 1.46–1.57)).

Conclusions

The results of this meta-analysis showed DM prevalence would affect the risk factor of colorectal adenoma with H. pylori infection.
Magnitude and Associated Factors of Delayed Immunization Among Children Aged 11 -23 Months in Edagahamus town, Tigray, Ethiopia, 2018.
Authors: Hagos Merhawit Gebremeskel , Gebremeskel Teferi Gebru , Kassahun Selam Shushay , Gebrezgi Birhane Hailu , Woldegebriel Manay Kifle 
Published: October 2019

Abstract
Background: Delay in receiving immunization is a major public health problem that has been associated with vaccine-preventable disease epidemics. In Ethiopia, many children have not received the benefits of age-appropriate immunization; thus more than 90% of child deaths are largely due to preventable communicable diseases. Therefore, the aim of this study to assess the magnitude and factors associated with delayed immunization among 12 -23 months old children’s in Edagahamus Town, Tigray, Ethiopia, and 2018 G.C.
Methods: A community-based Cross-Sectional study was carried out on July1-30, 2018. A simple random sampling method was used to select study participants. Information was collected using a structured, pre-tested questionnaire. Vaccination dates were obtained from children’s immunization cards and timeliness assessed based on the recommended age ranges. Data were entered and analyzed using SPSS version 20.0. Variable with P-value < 0.2 in bivariate was exported to multivariate. The strength of association was identified using the odds ratio with a 95 % confidence interval (CI) and the P-value of <0.05 in multivariate was taken statistically significant.
Results: In this study, the overall magnitude of delayed immunization was 29.5% (95%CI 26.7-45). Private firm work of mothers (AOR=0.205 95% CI 0.068-0.617) and Mothers who attend tertiary education (AOR 0.169, 95% CI 0.032-0.882) and secondary education (AOR 0.269, 95% CI 0.114-0.636) had the protective effect of delayed immunization. But the sickness of the child (AOR= 11.8, 95% CI 6.16-22.65) was a risk for delayed immunization.
Conclusions: From the study, it is concluded that the magnitude of delayed immunization for children aged 12-23 months is high (29.5%) in Edagahamus. Delayed immunizations of children were predicted by the Mother's occupation, education, and the mother considered the child was too ill to undertake vaccination when it was due.
Keywords: Child immunization, Delay to be immunized, Vaccine-preventable diseases
Integrated bioinformatics analysis reveals ASPM and CENPF with prognostic value in lung cancer
Authors: li jinghang , Zhang Jing , Huang Lin , Zhao Sheng 
Published: October 2019

Abstract
Lung cancer (LC) is the most frequent type of cancer in the world. But the mechanism of LC is still largely unknown. In this study, we analyzed three lung cancer gene expression microarrays of different pathologic types to explore the potential candidate genes in LC by Integrated bioinformatical methods. 459 overlapped differentially expressed genes (DEGs) were explored in three GEO gene expression profiles of different pathologic types of lung cancer and function annotation of DEGs were performed. The main biological process of DEGs was regulation of vasculature development and angiogenesis. The most significant molecular function of DEGs was TGF-β receptor activity. The most significant Reactome pathway of DEGs was cell cycle and extracellular matrix organization pathway. The PPI network of the DEGs was constructed and 23 candidate hub genes were identified in the network . Kaplan-Meier survival analysis show 21 genes were associated with the prognosis of LC. The genetic alterations analysis of these genes by using cBioPortal shown ASPM has the highest genetic alteration rate of 9% in main pathological types of 3191 LC patients , CENPF has the second highest alteration rate of 6% in LC patients. ASPM and CENPF also identified have a significant co-occurrence relationship in LC, and the GO analysis shown they both participate in the regulation of cell cycle. In the TF -miRNA-gene network of 21 genes shown CENPF have the most significant value in the network and the most relevant TF are NFYA, E2F1 and MYC.In conclusion, this study explored several key genes about LC and analyzed potential TF of those genes, provides possible therapeutic targets and biomarker for further clinical application.
Size of bone flap in decompressive craniectomy: an analysis of complications and prognosis in traumatic brain injury
Authors: Xu Min , Luo Yu , Yi Pan , Wang Cunzu 
Published: October 2019

Abstract
Abstract

Objective: To investigate association of size of bone flap with common complications and prognosis in traumatic brain injury.

Methods: A retrospective analysis was performed in 108 TBI patients of Northern Jiangsu People's Hospital from January 2018 to March 2019. Patients’ gender, age, Glasgow Coma Scale at admisson, pupils reactivity to the light, size of bone flap, types of craniocerebral injuries and injury locations were recorded. Prognostic indicators including changes in hematoma volume and neurological status were extracted. Statistical methods were conducted to evaluate drug efficacy. Prognostic indicators including Glasgow Outcome Scale scores at discharge and GOS scores of 6 months after operation were extracted to evaluate surgical effcacy.

Results : Postoperative complications such as encephalocele and subdural effusion were significantly associated with size of bone flap ( P <0.05). The incidence of encephalocele and SE increased with bone flap size in bone flap groups. Age, GCS at admisson, pupils reactivity to the light, and size of bone flap were shown significantly differences between prognosis groups ( P <0.05). By binary logistic regression, Age, pupils reactivity to the light, and the size of bone flap showed statistical significance ( P <0.05).

Conclusion: Size of bone flap in decompressive craniectomy is a dependent factor to prognosis. Avoiding oversize craniectomy may bring less complications and positive prognosis.