bluuebunny/crossref_metadata_2025_split huggingface dataset:
Екологія, ценотична гетерогенність формації бука лісового в Україні та збереження пралісових екосистем
Authors: Stoyko Stepan M. 
Published: November 2018

В Україні у гумідному кліматі Карпат існують оптимальні екологічні умови для зростання букових лісів, а на Поділлі – на східноєвропейській межі ареалу в сухішому кліматі – вони поширені лише локально. Подано екологічну оцінку фізико-географічних регіонів Карпат, Розточчя, Опілля, Поділля, в яких поширені монодомінантні й мішані бучини та встановлено їхню фітоценотичну різноманітність. З’ясовано роль антропогенних чинників, які є причиною зменшення їхньої площі. Подано перелік масивів природних бучин у Карпатах, внесених МАБ ЮНЕСКО до Списку об’єктів світової природної спадщини. Обґрунтовано науково-природниче й екомодельне лісівниче значення букових та інших пралісових екосистем
Відзначено, що пралісові фітоценози мають модельне значення для обґрунтування системи вирощування лісів, близьких за ценотичною структурою до природних екосистем та вибіркового лісокористування. Така система дає змогу усунути суперечності між екологічними вимогами щодо збереження постійності лісів та економічними потребами використання лісових ресурсів.
Наголошено, що пралісові екосистеми відзначаються біологічним різноманіттям. З їх осередків можлива міграція аборигенних видів флори й фауни у трансформовані прилеглі ліси та луки, що сприятиме покращенню їх ценотичної стабільності. У пралісових фітоценозах нагромадилася багата інформація про спонтанний розвиток лісів, їх природну вікову й ценотичну структуру. Тому праліси мають винятково важливе значення для дослідження лісотвірного процесу та функціонування екологічно стабільних екосистем.
У Карпатському біосферному заповіднику, в Національних природних парках «Зачарований край» та «Ужанський» представлена вся фітоценотична різноманітність монодомінантних й полідомінантних букових лісів країн Західної Європи. Вони мають важливе значення для обґрунтування екологічних засад відновлення бучин та ведення лісового господарства на природних засадах. Потрібно приділити належну увагу їх збереженню, дослідженню та впровадженню результатів у покращання екологічного стану лісів формації бучин.
Adultos com Deficiência Intelectual e Meios Digitais: Desenvolvimento Participativo de uma Campanha Audiovisual
Authors: Marques Catarina Alves , Santos Rita , Almeida Ana Margarida 
Published: November 2018

O presente artigo apresenta os resultados de um estudo que teve como objetivo o desenvolvimento participativo e avaliação de uma campanha audiovisual de sensibilização para a importância do uso dos meios digitais por parte de adultos com deficiência intelectual. O desenvolvimento da campanha envolveu um grupo de oito pessoas com deficiência intelectual, que colaborou nas fases de conceção, produção e pós-produção.
Numa primeira fase, através das entrevistas e pela observação durante as sessões de trabalho, foi possível caracterizar o perfil de experiência digital e audiovisual dos participantes. Posteriormente, procedeu-se ao desenvolvimento da campanha, tendo-se verificado que os contributos dos participantes com deficiência intelectual centraram-se na tomada de decisão, através de votações e, nas gravações, enquanto técnicos de imagem, som e elenco. Após o lançamento da campanha, aplicou-se um inquérito por questionário final que revelou a grande importância atribuída à temática e mostrou um feedback positivo relativamente à campanha audiovisual produzida, tanto em termos de conceção como ao nível de poder sensibilizador.
Phase I, First-in-Human, Dose-Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Vorolanib in Patients with Advanced Solid Tumors
Authors: Bendell Johanna C. , Patel Manish R. , Moore Kathleen N. , Chua Cynthia C. , Arkenau Hendrik-Tobias , Dukart Gary , Harrow Kim , Liang Chris 
Published: November 2018

Abstract

Lessons Learned
Pharmacokinetic results underscore that the vorolanib (X-82) study design was successful without the need for further dose escalation beyond 400 mg once daily (q.d.). Therefore, the recommended dose of X-82 as a single agent in patients with advanced cancer is 400 mg q.d.

Background
Vorolanib (X-82) is a novel, oral, multikinase vascular endothelial growth factor (VEGF) receptor/platelet-derived growth factor (PDGF) receptor inhibitor that was developed on the same chemical scaffold as sunitinib, but designed to improve upon the safety profile while maintaining the efficacy of sunitinib. By targeting the VEGF and PDGF receptors, X-82 was expected to disrupt tumor angiogenesis and be active in a broad spectrum of solid tumors. Therefore, we determined the maximum tolerated dose (MTD) and characterized the preliminary pharmacokinetics and clinical tumor response of X-82 as a single agent in patients with advanced solid tumors.

Methods
Adult patients with advanced solid tumors received X-82 as tablets or capsules (once daily [q.d.] or b.i.d.) every 4 weeks. Patients were evaluated for response every 8 weeks, and continued treatment until disease progression or intolerable toxicity.

Results
Fifty-two patients received study treatment in 17 cohorts. X-82 capsule dosing was as follows: cohorts 1–6 (20–400 mg q.d.) and cohorts 7–8 (140–200 mg b.i.d.). Patients in cohorts 9–17 received 50–800 mg q.d. tablet dosing. The median time on treatment was 58 days. X-82 blood pharmacokinetics appeared dose-independent with a t1/2 of 5.13 hours and 6.48 hours for capsule and tablet formulations, respectively. No apparent accumulation was observed after 21 days of daily dosing.

Conclusion
X-82 had a safety profile consistent with its mechanism of action. It has a short half-life and was well tolerated by most patients. Study enrollment ended prior to the determination of the MTD because of the apparent saturation of absorption at 400–800 mg. The recommended dose of X-82 as a single agent in patients with advanced cancer is 400 mg q.d.
Let’s talk about sex history: impact of a communication curriculum on medical student performance and perceived competency
Authors: Stockdale Colleen K , Elson Marygrace , Kippes John , Rosenbaum Marcy 
Published: November 2018

Determine whether medical students (MS) who completed a sexual history communication curriculum performed better
during a formal standardized patient based assessment (PBA) at the
conclusion of the OB/GYN Clerkship than historical control MS, and
assess MS perceptions about taking a sexual history.
Prevalence of female reproductive tract cancer in a teaching hospital of Rohtas District, Bihar, India
Authors: Kumar Rajendra 
Published: November 2018

Background: The organs of female reproductive tract are involved by various ailments up to malignancy and different types of malignancy involve these organs causing unbearable symptoms to the patient and harassment to the affected family. However, the incidence varies, and cervical carcinoma is more common in Asian countries even after use of screening tests in specialized hospitals. The study was undertaken to assess the prevalence of malignancy of these organs among females in this location of Rohtas district of Bihar.Methods: A study of female reproductive system was done retrospectively for a period of 3 years and the suspected 1409 patients underwent operative procedures and tissues were microscopically examined of haematoxylin and eosin stained slides by conventional methods.Results: Of the 58 malignant cases of female reproductive organs, cervical carcinoma emerged as the commonest with 56.9%, followed by endometrial carcinoma (22.4%), and ovarian cancers (15.5%). The vaginal and vulval cancers were found to be the lowest with 3.4% and 1.7% cases respectively.Conclusions: The squamous cell carcinoma (67%) was the commonest malignancy of cervical cancers whereas adenocarcinoma (85%) was the most common involvement of endometrial carcinoma histologically diagnosed.
Roughness Coefficient of a Highly Calcinated Penstock
Authors: ÇELEBİOĞLU Kutay 
Published: November 2018

When highly calcinated water is transferred through the penstock of a hydropower plant it leaves a residue on the pipe surface. Accumulated residue over time causes a change in the roughness of the pipe surface thus friction losses in the system. The effect is a change in head and discharge relation for the turbines. A multimethodology is proposed for determining the apparent surface roughness value (ε) by means of friction factor f and measuring arithmetic mean deviation of the roughness profile (Ra), root mean square roughness (Rq) and peak and valley roughness (Rz). It is found that a surface roughness value (ε) of 0.3mm can be used for calcinated surfaces which is much higher than steel surfaces but smaller than concrete.
PERKEMBANGAN PERAKITAN VARIETAS DAN TEKNIK BUDI DAYA JAGUNG ANTIOKSIDAN SEBAGAI PANGAN FUNGSIONAL
Authors: HG M Yasin , Talanca A. Haris , Mejaya M Jana 
Published: November 2018

<p align="center">ABSTRAK</p><p>Jagung antioksidan mengandung beta karoten pada endosperm yang bermanfaat untuk kesehatan, antara lain dapat mencegah buta dini (rabun/katarak), kerontokan rambut, memperkuat jaringan tubuh, dan mencegah gizi buruk pada anak balita. Kementerian Pertanian telah melepas tiga varietas jagung antioksidan kaya beta karoten, dua dari jenis bersari bebas (varietas Provit A1 dan Provit A2) dan satu dari jenis hibrida (varietas Bima Provit A1) masing-masing dengan kadar beta karoten 155,3-281,6% lebih tinggi dari jagung biasa. Potensi hasil jenis bersari bebas dapat mencapai 7,36 t/ha dan jenis hibrida 9,85 t/ha. Budi daya jagung antioksidan sama dengan jagung biasa. Aspek yang perlu mendapat perhatian adalah isolasi jarak tanaman, minimal 300 m, dan isolasi waktu tanam 3 minggu setelah tanam dengan tanaman jagung biasa. Hal ini diperlukan untuk menghindari xenia effect, yaitu pengaruh tepungsari jagung biasa yang menyerbuki jagung antioksidan sehingga kadar antioksidannya akan menurun dan statusnya kembali sama dengan jagung biasa. Hasil panen dapat dijadikan bahan baku industry berbagai makanan olahan bergizi tinggi. Pengembangan jagung antioksidan, terutama di Kawasan Timur Indonesia perlu peran pemerintah setempat dalam upaya mempercepat adopsi oleh petani.</p><p>Kata kunci: Jagung, antioksidan, beta karoten, pangan fungsional</p><br /><p align="center"><strong> </strong></p><p align="center">ABSTRACT</p><p>Antioxidant maize contains beta carotene in the endosperm that is beneficial for health, such as can prevent early blindness (blindness / cataract), hair loss, strengthen body tissues, and prevent malnutrition in children under five. The Ministry of Agriculture has released three varieties of beta-carotene-rich antioxidant maize, two of the free-range (Provit A1 and Provit A2) varieties and one of the hybrid varieties (Bima Provit A1) each with carotene beta levels of 155.3 to 236.6 % higher than ordinary corn. The potential of free pollen type yield can reach 7.36 t / ha and hybrid type 9.85 t / ha. The cultivation of antioxidant corn is the same as ordinary corn. Aspects that need attention are isolation of plant spacing, at least 300 m, and isolation of planting time 3 weeks after planting with ordinary corn crops. This is necessary to avoid the xenia effect, which is the effect of ordinary corn corn that pollinate antioxidant corn so that its antioxidant levels will decrease and its status is the same as ordinary corn. Yields can be used as industrial raw materials of various highly processed nutritious foods. Development of antioxidant maize, especially in Eastern Indonesia needs the role of local government in an effort to accelerate adoption by farmers.</p><p>Keywords: Maize, antioxidant, beta caroten, functional food.</p>
Volumetric Efficiency Evaluation of Sucker-Rod-Pumping Applications Performed on a Pump Testing Facility
Authors: Kochtik Daniel , Langbauer Clemens 
Published: November 2018

Abstract
Low oil prices at the stock market and high water cuts of the produced fluid, force the oil companies to continuously optimize their facilities to meet the actual requirements regarding efficiency. One step in the chain of oil production from the reservoir to the customer is the optimization of artificial lift systems in mature oil fields. Nowadays sucker rod pumping systems are still by far the most frequently used artificial lift systems. These pumps represent an efficient and simple way to increase the oil production. On the one hand from the technical point of view, this system is easily adjustable to changing operating conditions. On the other hand, its economic footprint is, compared to other artificial lift methods, relatively small.
Due to the huge number of installed units, an energy efficient and failure resistant design is essential. A deep understanding of the actual process during pumping is significant for continuously optimizing the pumping system. This paper presents the evaluation of volumetric efficiency tests, performed at the Pump Testing Facility (PTF) at the Montanuniversität Leoben, under various operating conditions and the investigating of the related physical effects.
Slippage, one of the most influencing factors of volumetric efficiency, is highly dependent on the differential pressure generated by the pump plunger, but as well on the strokes per minute. The results of various attempts that were performed to get a detailed understanding of the internal losses (slippage volume) during the pumping operation are shown. Two different pump types, namely the standard sucker rod pump (SRP) and the sucker rod anti-buckling system pump (SRABS) are tested with different fluid types. Both pumps were operated with various speeds and under different pressure conditions. The test results are compared with existing slippage models. The comparison indicates that most of the existing slippage models underpredict the slippage rate by a significant fraction. Therefore, it is necessary to do additional and more detailed tests to be able to define a more precise model to predict slippage losses during pumping operations.
Enhanced Sucker Rod Pumping Model: A Powerful Tool for Optimizing Production, Efficiency and Reliability
Authors: Di Tullio Matteo Tommaso , Marfella Ferdinando 
Published: November 2018

Abstract
As the oil industry begins to emerge from one of the worst downturns in decades, companies need to operate in a market of unstable oil prices that the upstream oil and gas industry continues to face. New innovative, sustainable, and disruptive artificial lift technologies are the cost-effective way seek by the operators to minimize risks, maximize production, and remain profitable on the market.
In wells with sucker rod-lift systems, elastic beam vibrations induced by downhole pump operation are the main source for premature rod string failure and tubing wear. A completely new steady-state vibrations model for rod string assemblies has been implemented to understand and predict the rod/tubing wear damage phenomenon responsible for half of all well failure events in beam pump operation and most expensive routine well servicing cost.
This paper introduces the developed model to enhance prediction of mechanical rod string dynamics during pumping operation, and delivers next generation analytics solution to be utilized for artificial intelligence, industrial internet of things, real-time monitoring, and automation of rod pumping systems.
The model works on a set of forced Duffing-like differential equations with cubic non-linearity and damping, these generated discretizing beam elastic behavior using vibration mode basis. Model simulation runs in the time domain numerically capture relevant axial-flexural dynamic forces undergone by rod string during up and down stroke phases, as well as downstroke rod string bending-buckling tendency and its interaction with tubing internal wall.
Some examples show usefulness of the novel model to predict failures and maximize uptime, reduce costs with predictive analytics, and design the optimal rod lift solution in every stage of well life cycle.
Distinct Features of the Self-Concept and the Meaning-Forming Motives of Intellectual Professionals: A Case of Australian and Russian Specialists of Intellectual Labour
Authors: Obukhova Julia V. , Komarovskaya Ekaterina L. 
Published: November 2018

Introduction. The authors substantiate the necessity and relevance of studying the features of self-concept and the meaning-forming motives for intellectual labour. The novelty of this study is that a comparative analysis of the particularities of self-concept and the meaning-forming motives of the Australian and Russian specialists of intellectual labour is carried out for the first time.
Methods. The study is based on the survey of 30 Australian and 40 Russian professionals in various fields of intellectual labour, whose average age was 34 years and 36 years old respectively. Psychological testing and content analysis of respondents’ self-descriptions were used as primary methods of research. The questionnaire with open-ended items created by the authors, entitled “Meaning-Forming Motives of Labour Activity – Money”, has been used for data collection. Parametric and nonparametric statistical procedures were carried out in analyses.
Results and Discussion. This section describes the features of cognitive and emotional-evaluative components of self-concept, work-related meaning-forming motives of Australian and Russian professionals in the field of intellectual labour, both men and women. The leading categories in self-descriptions of the respondents are dependent on their nationality and gender. The following features of self-concept were revealed in the study: Australian men describe themselves through their look, Australian women – through their hobbies and friendships, Russian women – through their society status and social environment. The obtained results can be used in the development of a general management system and of training programs for professionals in the field of intellectual labour.
Коллективная память о России ХХ века и ценности разных поколенческих групп
Authors: Baranova Victoria A. , Zhukova Maria O. 
Published: November 2018

Введение. Авторами рассматривается актуальность подхода к изучению коллективной памяти с позиций конструкционизма. При изучении коллективной памяти в данном исследовании научные задачи направлены на выявление событийного ряда, который конструирует групповые воспоминания, определяя то, что имеет для одной поколенческой группы современного общества большую значимость, чем для другой. Новизна исследования заключается в выявлении преобладающих ценностей каждой поколенческой группы и характеристике содержания коллективных воспоминаний о России ХХ века с учетом ведущих групповых ценностей.
Методы. В исследовании применяются методы количественного и качественного анализа: ассоциативная методика, методика для выявления ценностей Ш. Шварца, анкета для сравнения России XX века и идеальной России. Выборку исследования составили респонденты разного возраста из различных регионов России, всего 90 человек.
Результаты. Данный раздел включает описание содержания групповых воспоминаний о России ХХ века, групповой структуры преобладающих ценностей, результаты сравнения России ХХ века с идеальной Россией для трех возрастных групп. Содержание воспоминаний о России ХХ века и результаты сравнения России XX века и идеальной России отражают групповую поколенческую специфику: содержание представлено различными событиями; Россия представляется как страной, далекой от идеала, так и оценивается высоко. При исследовании групповых ценностей выявлено, что для каждой поколенческой группы характерна собственная структура.
Обсуждение результатов. Анализ воспоминаний о России ХХ века показал, что их содержание отражает групповую специфику отношения к прошлому. Полученные результаты подтвердили гипотезу о существовании групповых особенностей конструирования коллективных воспоминаний об историческом периоде, что дает возможность определять коллективную память как необходимое свойство социальной группы. В исследовании описан феномен «поколенческой сензитивности», проявляющийся в повышенной чувствительности (восприимчивости) к прошедшим и происходящим событиям представителей разных социальных поколенческих групп.
Carbon Nano-onions: A Valuable Class of Carbon Nanomaterials in Biomedicine
Authors: Giordani Silvia , Camisasca Adalberto , Maffeis Viviana 
Published: November 2018

:
The development of nanoscale materials is an important area of research as it provides access
to materials with unique properties that can be applied to improve quality of life. Multi-layer fullerenes,
also known as carbon nano-onions (CNOs) are an exciting class of nanostructures which show great versatility
and applicability. They find applications in several fields of technology and biomedicine. This
review highlights the potential advantages of CNOs for biomedical applications, which include but are
not limited to bioimaging and sensing. Their good biocompatibility renders them promising platforms for
the development of novel healthcare devices.
Human Breast Milk-acquired Cytomegalovirus Infection: Certainties, Doubts and Perspectives
Authors: Bardanzellu Flaminia , Fanos Vassilios , Reali Alessandra 
Published: November 2018

Breast Milk (BM) is the best source of nutrition for newborns, especially if premature. In fact, its beneficial impact on short- and the long-term neonatal outcome has was deeply described.Unfortunately, BM could not be always so safe, especially due to the possible presence of maternal viruses that can be shed and transferred to the breastfed neonate. Among these, Cytomegalovirus (CMV) can potentially lead to a serious and acute illness, mostly in case of low gestational age.Some studies also report the association of CMV-acquired infection to an increased risk of structural and functional brain modifications and neurological impairment.Due to these reasons, a strategy to remove CMV from BM with a minimal or absent impact on its beneficial components would be desirable.Up to now, pasteurization, freezing, ultraviolet- C or microwave irradiation are the available techniques; they show different levels of efficacy and variable effects on BM composition, even if many studies are still needed to fully clarify these implications.In this review, we provide an update of the current evidence about these topics. We focus on the factors promoting CMV shedding through BM; moreover, the possible occurrence of a severe disease in preterm neonates is also described. Finally, we investigate the potential effects showed on BM properties by the strategies that prevent or reduce viral transmission, therefore influencing newborns’ health, and the new techniques which could show a relevant role in the next future, such as metabolomics.