bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do psychosocial job stressors influence mental health service use? Evidence from an Australian cohort
Authors: Milner Allison , Petrie Dennis , LaMontagne Anthony D , Butterworth Peter 
Published: March 2019

ObjectivesThere is strong evidence of a relationship between psychosocial job stressors and mental health at the population level. There has been no longitudinal research on whether the experience of job stressors is also associated with greater mental health service use. We seek to fill this gap.MethodsThe Household Income Labour Dynamics in Australia survey cohort was used to assess the relationship between exposure to self-reported psychosocial job quality and reporting attendance at a mental health professional during the past 12 months. We adjusted for time-varying and time-invariant confounders. The study was conducted in 2009 and 2013.ResultsIn the random effects logistic regression model, increasing exposure to psychosocial job stressors was associated with an increased odds of mental health service use after adjustment (one stressor: OR 1.26, 95% CI 1.01 to 1.56; two stressors: OR 1.33, 95% CI 1.02 to 1.73; three stressors: OR 1.82, 95% CI 1.28 to 2.57). However, once the between person effects were controlled in a fixed effects model, the within-person association between change in job stressors and change in mental health service use was estimated to be close to zero and not significant.ConclusionsMore work is needed to understand the relationship between job stressors and service use. However, when taken with past findings on job stressors and mental health, these findings highlight the importance of considering policy and clinical practice responses to adverse working contexts.
Down-regulation of the inflammatory response after short-term exposure to low levels of chemical vapours
Authors: Ernstgård Lena , Bottai Matteo , Johanson Gunnar , Sjögren Bengt 
Published: March 2019

ObjectiveTo investigate the relation between signs and symptoms of irritation and biomarkers of inflammatory markers in blood in healthy volunteers exposed to different chemical vapours for 2 or 4 hours in an exposure chamber.MethodsThe investigated chemicals were: acetic acid (5 and 10 ppm), acrolein (0.05 and 0.1 ppm), 1,4-dioxane (20 ppm), n-hexanal (2 and 10 ppm), hydrogen peroxide (0.5 and 2.2 ppm), 2-propanol (150 ppm), m-xylene (50 ppm), standard and dearomatised white spirit (100 and 300 mg/m3). C reactive protein (CRP), serum amyloid A protein and interleukin 6 were measured in plasma immediately before and 2 or 4 hours after the exposures. Symptoms were rated from 0 to 100 mm in Visual Analogue Scales and covered 10 questions whereof four related to irritation: discomfort in the eyes, nose and throat and dyspnoea. The effect measurements included blink frequency by electromyography, nasal swelling by acoustic rhinometry and lung function by spirometry.ResultsLogistic quantile regression analyses revealed no significant associations except a negative relation between ratings of irritation and CRP.ConclusionThe results suggest a down-regulation of CRP after short-term exposure to low levels of vapours of irritating chemicals. This response might be mediated by the cholinergic anti-inflammatory pathway and further studies are recommended in order to refute or confirm this hypothesis.
Fetlock arthrodesis using DCP internal fixation in a Bactrian camel (Camelus bactrianus) for treatment of metacarpophalangeal joint hyperextension
Authors: McLean Kanyon , Lozier Joseph , Lakritz Jeffrey , Niehaus Andrew John 
Published: March 2019

A 21‐month‐old intact, male Bactrian camel (Camelus bactrianus) presented for bilateral metacarpophalangeal joint hyperextension. Physical and radiographic evaluation revealed evidence of soft tissue hyperextension with no bony changes. The left metacarpophalangeal joint was fused using two dynamic compression plates on the dorsal aspect of the joint along with a figure‐8 tension band on the palmar aspect of the lateral fetlock for additional structural support. Twenty‐seven days postoperatively, the patient was able to weightbear on both thoracic limbs. The patient was released with recommendations to have the contralateral limb corrected in the near future. Follow‐up communication with the referring veterinarian revealed no known complications with the surgically corrected limb four months postrelease. This report illustrates the adaptation of a commonly reported surgical procedure in equine medicine and supports its use for correction of metacarpophalangeal joint hyperextension in artiodactylids not amenable to long‐term medical management.
Treatment of thirst in broilers in a low‐throughput abattoir
Authors: Cranley John James 
Published: March 2019

Thirst in broilers was satisfied by water provision while awaiting slaughter at a one‐day‐per‐week poultry abattoir in England. Two consignments, of 7000 broilers in total, during high summer and in April were compared. The ambient temperature by the end of slaughter was over 29°C at 16.00 hours in summer, whereas in spring the peak was 14°C. Broilers were given water from a bubbling hose or water dish, the walls of the module drawer were dripped with water, and an industrial electric cooling fan was used during hot conditions. Nipple‐watered birds, once their fear of the plastic hose subsided, drank enthusiastically as depicted on the video. Thirst became more severe, as the period of water deprivation, heat and travel stress increased to eight hours or more, especially once the ambient temperature exceeded 17°C. Broilers responded as did thirsty horses, cattle or pigs.
Management and resolution of acquired myasthenia gravis in a carbimazole‐treated hyperthyroid domestic shorthair cat
Authors: Ellis Jenny , Tappin Simon 
Published: March 2019

An 11‐year‐old male neutered domestic shorthair cat presented with acute onset signs of generalised weakness and neck ventroflexion. He had been diagnosed with hyperthyroidism two months previously and been treated with daily carbimazole. No haematological, biochemical or electrolyte abnormalities were evident to explain his signs; thoracic and abdominal imaging was unremarkable. A positive response to a neostigmine response test and high acetylcholine receptor antibody titre were consistent with a diagnosis of myasthenia gravis. The temporal association with treatment of hyperthyroidism suggested acquired myasthenia gravis secondary to carbimazole, and the cat underwent successful surgery for thyroidectomy to avoid the need for ongoing medical therapy. Acetylcholine receptor antibody levels remained high four months later before returning to normal after a further two months. Clinical signs were completely controlled with pyridostigmine, which was tapered and eventually withdrawn, and the cat returned to a normal quality of life.
İZMİR-TURGUTLU (HAMİDİYE) KÖYÜNDE GİRİTLİ MUHACİRLER
Authors: ŞAHİN Cemile , DURAN Gamze 
Published: March 2019

Girit’te
yaşayan Müslüman Türk nüfus ilk olarak; 19. yüzyılın sonlarında milliyetçi
akımların ve Yunan bağımsızlık hareketinin Girit’i de etkilemesiyle adada
başlayan milliyetçi çatışma ve katliamlar neticesinde yurtlarını terk ederek
adadan göç etmek zorunda kalmıştır. Daha sonra ise; Girit’in Osmanlı
hâkimiyetinden çıkmasıyla burada azınlık statüsünde yaşayan Girit Müslümanlarının
“Mübadele” anlaşmasıyla adadan yine zorunlu göç süreci yaşanmıştır. Böylece
yaşanan iki büyük göç dalgasıyla Müslüman nüfus, Anadolu’ya taşınmıştır. Bu
çalışmada; Müslüman halkın, 19. yüzyılda özellikle 1897 Osmanlı-Yunan Savaşı
ile birlikte baskı ve katliamlar sonucu Girit’ten Anadolu’ya yönelik zorunlu
göç ya da zorunlu kaçış süreci neticesinde İzmir’e gelmeleri ve burada Turgutlu
(Hamidiye) köyüne iskânları, sosyal ve kültürel değerleri ele alınarak, gerekli
değerlendirmeler yapılmaya çalışılmıştır. Bu çalışmanın amacı; tarihi belgeler,
alan çalışması ve konu ile ilgili
yapılan çeşitli araştırmalar çerçevesinde, Giritli Müslümanların İzmir’e
gelişleri, Turgutlu (Hamidiye) köyünün kuruluşu ve buraya iskân edilmeleri, kaç
haneden mürekkep oldukları, meslekleri, temel geçim kaynakları, yörenin diğer
toplumsal gruplarıyla olan ilişkileri, kültürel adaptasyonları, Turgutlu
(Hamidiye) köyünün günümüzdeki durumu ve Giritli muhacirlerin tarihsel süreç
içerisinde geçirmiş oldukları dönüşümü irdeleyerek, farklı bir bakış açısı ortaya koyabilmektir. Konuya
özgünlük ve bütünlük sağlaması açısından, dönemin gazeteleri ve arşiv belgelerine
ayrıca bölgedeki üçüncü ve dördüncü kuşak Giritli vatandaşların
konu ile ilgili bizzat kendi ifadelerine yer verilmeye dikkat edilmiştir.
Autophagy pathways in drug abusers after forensic autopsy: LC3B, ph-mTOR and p70S6K analysis
Authors: Chindemi Chiara , Cirielli Vito , Cima Luca , Danzi Olivia , Raniero Dario , Tagliaro Franco , Turrina Stefania , Eccher Albino , Ghimenton Claudio , Bortolotti Federica , Brunelli Matteo , De Leo Domenico 
Published: March 2019

Introduction Autophagy plays a role in various central nervous system diseases. Little is known about its molecular activation in drug addiction. Our aim was to investigate the signalling pathways of autophagy in brain tissues from drug abusers. Methods Twenty-five drug abusers with acute lethal intoxication and 10 controls were medico-legally autopsied. Brain-tissue samples from the parietal cortex and cerebellum were obtained. Expression of LC3B, phospho-mTOR (ph-mTOR) and phospho70S6 Kinase (p70S6K) was identified in tissue microarrays, with three tissue spots per case. Blood, urine or vitreous humour were tested in all cases to identify the acute intoxication. Hair analysis was performed in 14 cases to confirm chronic intoxication; the remaining cases had a documented medical history of chronic abuse. Results The autophagy marker LC3B was always positive on both the cortex and the cerebellum, stratified as strongly in 18 (72%) cases and weakly positive in seven (28%) cases. ph-mTOR was negative in all cases. The p70S6K molecule showed positivity in 14 (56%) cases on cortex tissue. The cerebellum was always negative, except for Purkinje cells. Drug abusers had statistically more double positive cases (LC3B–p70S6K) than controls ( p=0.0094). Conclusion Autophagy pathways were activated in our series, and 56% of drug abusers showed simultaneous LC3B–p70S6K immunoexpression on tissue from the parietal cortex and cerebellum. This may be of value in autopsy practice as an indicator of brain damage due to drug abuse and could serve as alternative or additional double sensitive diagnostic method to detect drug-related deaths using a tissue-based rationale.
Confocal laser endomicroscopy reveals alterations in duodenal permeability in patients with acute pancreatitis
Authors: Sun Lingjia , Yue Min , Dai Yining , Yu Chaohui , Chen Chunxiao 
Published: March 2019

Objective Intestinal permeability increases during the course of acute pancreatitis (AP). We assessed duodenal permeability alterations in patients with AP by confocal laser endomicroscopy (CLE). Methods Thirty patients with AP underwent CLE evaluation of the antral and duodenal mucosa. Images were graded based on the appearance of capillaries and the degree of fluorescein leakage. Results Patients with AP had increased duodenal mucosal permeability that could be detected by CLE. The mucosal permeability progressively increased in the gastric antrum, duodenal bulb, and descending duodenum. The CLE parameters in the antrum and duodenal bulb were not significantly different between patients with mild and severe AP. The CLE grades in the descending duodenum were higher in patients with severe than mild AP. The C-reactive protein level in AP was positively correlated with the permeability in the duodenal bulb and descending duodenum, while the computed tomography severity index score was positively correlated with the mucosal permeability in the duodenal bulb and descending duodenum. Conclusion CLE revealed increased duodenal permeability in patients with AP. Higher permeability in the descending duodenum was observed in severe than mild AP. Further large-scale studies are needed to confirm the relationship between altered duodenal permeability and the severity of AP.
Maintaining health-related quality of life from 85 to 93 years of age despite decreased functional ability
Authors: Johansson Maria M , Marcusson Jan , Wressle Ewa 
Published: March 2019

Introduction The ‘oldest-old’ is the most rapidly growing age group in Sweden and in the western world. This group is known to be at great risk of increased functional dependency and the need for help in their daily lives. The aim of this research was to examine how the oldest-old change over time regarding health-related quality of life, cognition, depression and ability to perform activities of daily living and investigate what factors explain health-related quality of life at age 85 and 93 years. Methods In this study, 60 individuals from the Swedish Elderly in Linköping Screening Assessment study were followed from age 85 to 93 years. Measurements used were EQ-5D, Geriatric Depression Scale, Mini Mental State Examination and ability to perform activities of daily living. Nonparametric statistics and regression analyses were used. Results Although the individuals had increased mobility problems, decreased ability to manage activities of daily living, and thus had increased need of assistance, they scored their health-related quality of life at age 93 years at almost the same level as at age 85 years. No depression and low dependence in activities of daily living speaks in favour of higher health-related quality of life. Conclusions Health-related quality of life can be maintained during ageing despite decreased functional ability and increased need of assistance in daily life.
Calcitonin gene-related peptide and disease activity in cluster headache
Authors: Snoer Agneta , Vollesen Anne Luise H , Beske Rasmus P , Guo Song , Hoffmann Jan , Fahrenkrug Jan , Jørgensen Niklas Rye , Martinussen Torben , Jensen Rigmor H , Ashina Messoud 
Published: March 2019

Objective To investigate the role of calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide in cluster headache, we measured these vasoactive peptides interictally and during experimentally induced cluster headache attacks. Methods We included patients with episodic cluster headache in an active phase (n = 9), episodic cluster headache patients in remission (n = 9) and patients with chronic cluster headache (n = 13). Cluster headache attacks were induced by infusion of calcitonin gene-related peptide (1.5 µg/min) in a randomized, double-blind, placebo controlled, two-way cross-over study. At baseline, we collected interictal blood samples from all patients and during 11 calcitonin gene-related peptide-induced cluster headache attacks. Results At baseline, episodic cluster headache patients in remission had higher plasma levels of calcitonin gene-related peptide, 100.6 ± 36.3 pmol/l, compared to chronic cluster headache patients, 65.9 ± 30.5 pmol/l, ( p = 0.011). Episodic cluster headache patients in active phase had higher PACAP38 levels, 4.0 ± 0.8 pmol/l, compared to chronic cluster headache patients, 3.3 ± 0.7 pmol/l, ( p = 0.033). Baseline levels of vasoactive intestinal polypeptide did not differ between cluster headache groups. We found no attack-related increase in calcitonin gene-related peptide, PACAP38 or vasoactive intestinal polypeptide levels during calcitonin gene-related peptide-induced cluster headache attacks. Conclusions This study suggests that cluster headache disease activity is associated with alterations of calcitonin gene-related peptide expression. Future studies should investigate the potential of using calcitonin gene-related peptide measurements in monitoring of disease state and predicting response to preventive treatments, including response to anti-calcitonin gene-related peptide monoclonal antibodies.
The impact of initiating posaconazole on tacrolimus pharmacokinetics in allogeneic stem cell transplantation
Authors: Collins Jennifer , Shea Katherine , Parsad Sandeep , Plach Kelly , Lee Pauline 
Published: March 2019

Background Posaconazole reduces the risk of invasive Aspergillus in transplant patients, but significantly inhibits tacrolimus metabolism. One study demonstrated that a three-fold dose reduction of tacrolimus was required to obtain therapeutic concentrations when used with posaconazole. However, with empiric dose reduction, there is a risk of subtherapeutic tacrolimus levels and subsequent graft failure or graft-versus-host disease. Overall, the existing data on the impact of posaconazole on tacrolimus pharmacokinetics is limited. Objective The purpose of this study is to determine whether tacrolimus doses should be decreased upon initiation of posaconazole in patients receiving an allogeneic stem cell transplant. Methods This is a retrospective chart review at an academic medical center. All allogeneic stem cell transplant adults who received concomitant posaconazole and tacrolimus from February 2016 through December 2017 were included. Results Seventy-nine patients identified using an internal electronic database were analyzed. The median time to therapeutic tacrolimus concentration was significantly longer in patients who did not receive an empiric dose reduction (0% DR, 10d; 1–30% DR, 4d; 31–65% DR, 5d; >65% DR, 4d; p = 0.0395). The rate of supratherapeutic levels was highest amongst patients who did not receive an empiric DR, and was noted to be significant compared to the group that had 31–65% DR ( p < 0.001). Conclusion This study validates our current practice of instituting an empiric 50% dose reduction of oral tacrolimus to 0.03 mg/kg/day when used concomitantly with posaconazole to achieve therapeutic levels in allogeneic stem cell transplant patients.
Tbo-filgrastim versus filgrastim for stem cell mobilization and engraftment in autologous hematopoietic stem cell transplant patients: A retrospective review
Authors: Potter Ashley , Beck Bradley , Ngorsuraches Surachat 
Published: March 2019

Introduction Filgrastim, a granulocyte colony-stimulating factor, is commonly used in autologous hematopoietic stem cell transplants (HSCTs) to assist with peripheral blood progenitor cell (PBPC) collection and to support stem cell engraftment. In the United States, tbo-filgrastim is approved under its own Biologic License Application and is limited to a single indication excluding the HSCT population. Methods Approximately one year after a system-wide formulary change to tbo-filgrastim for all on- and off-label indications, our institution conducted an IRB-approved retrospective comparison of tbo-filgrastim to filgrastim in the autologous HSCT setting. The study included 71 patients who received an autologous HSCT from 1 January 2013 to 31 December 2016 with a documented administration of tbo-filgrastim or filgrastim. Results There were no statistically significant differences noted on CD34 + counts during stem cell mobilization, neutrophil engraftment, infection rates during the engraftment phase, nor duration of hospitalization during the engraftment phase. More patients in the tbo-filgrastim group received plerixafor per protocol resulting in more patients meeting their PBPC collection goal in one day with fewer collection days overall, a result potentially confounded by institutional protocol changes. Utilizing tbo-filgrastim offered an average cost savings per patient of $2664.26 ($1907.33 for PBPC mobilization and $756.93 for stem cell engraftment) when comparing dollars spent on granulocyte colony-stimulating factor products only. Conclusion Tbo-filgrastim demonstrates comparable efficacy with a cost savings benefit compared to filgrastim for autologous PBPC mobilization and stem cell engraftment.
Correlating transcranial arterial Doppler velocities with haematologic parameters and haemolytic indices of Nigerian children with sickle cell anaemia
Authors: Ismail Anas , Yusuf Aminu Abba , Kuliya-Gwarzo Aisha , Ahmed Sagir Gumel , Tabari Abdulkadir Musa , Abubakar Shehi Ali 
Published: March 2019

Introduction Cerebral vasculopathy, elevated transcranial Doppler velocities and stroke are linked to excessive intravascular haemolysis in sickle cell anaemia. This study determined the prevalence and pattern of abnormal blood flow velocities in children with sickle cell anaemia from Northern Nigeria using transcranial Doppler and to correlate transcranial Doppler velocities with haematological and biochemical markers of haemolysis. Methods Full blood count, reticulocyte count, fetal haemoglobin and some selected biochemical markers of haemolysis of 100 children with sickle cell anaemia were determined at steady state. The time-averaged mean of maximal velocities in four major intracranial blood vessels was measured using non-imaging transcranial Doppler, which were then classified according to the stroke prevention in sickle cell disease trial protocol. A simple linear correlation between time-averaged mean of maximal velocities in the four major intracranial vessels as the dependent variable and haematological and biochemical markers of haemolysis as independent variables was also determined at the significance level of 0.05. Results Abnormal transcranial Doppler velocities, classified as high risk, were found in 3% of the studied patients; 11% had intermediate risk while 84% had standard risk. Most high velocities were detected in the middle cerebral artery. The time-averaged mean of maximal velocities of middle cerebral artery positively correlated with total white blood cell count, absolute neutrophil count, platelet count, reticulocyte count, serum lactate dehydrogenase and total bilirubin, while it was negatively correlated with haematocrit and fetal haemoglobin levels. Conclusion Our study showed low prevalence of abnormal transcranial Doppler velocities and low prevalence is unrelated to low markers of haemolysis in our study population.
Everolimus-eluting bioresorbable scaffolds for treatment of coronary artery disease in patients with diabetes mellitus: the midterm follow-up of the prospective ABSORB DM Benelux study
Authors: Hommels T. M. , Hermanides R. S. , Rasoul S. , Berta B. , IJsselmuiden A. J. J. , Jessurun G. A. J. , Benit E. , Pereira B. , De Luca G. , Kedhi E. 
Published: March 2019

Abstract
Background
Percutaneous coronary intervention (PCI) in patients with diabetes mellitus (DM) remains challenging even with modern drug-eluting stents (DES) due to high rates of repeat revascularization. Everolimus-eluting bioresorbable scaffolds (EE-BRS) might allow for repeat intervention prolonging the time interval of percutaneous treatment options.

Methods
The ABSORB DM Benelux Study is a dedicated prospective, international study to evaluate the midterm safety and efficacy of EE-BRS in DM patients. All DM patients that received ≥ 1 EE-BRS for any indication were enrolled and prospectively followed. Study endpoints were major adverse cardiac events (MACE): a composite of all-cause death, any myocardial infarction (MI) and ischemic-driven target vessel revascularization (TVR); target lesion failure (TLF): a composite of cardiac death (CD), target vessel MI, and ischemic-driven target lesion revascularization (TLR), as well as definite or probable scaffold thrombosis (ScT).

Results
Between April 2015 till March 2017, 150 DM patients and 188 lesions were treated and followed up to 3 years. Device implantation success was 100%. MACE occurred in 15.2% (event rate of 8.8 per 100 PY). TLF was reported in 11.7% (7.0 events per 100 PY). CD, target vessel MI, ischemic-driven TLR occurred in 3.4%, 3.6% and 5.5% respectively, while ScT was observed in 1.4%. There were no occurrences of late or very late ScT.

Conclusion
EE-BRS treatment in DM patients shows comparable midterm safety and efficacy outcomes when historically compared with modern DES. New-generation EE-BRS might offer an attractive alternative to metallic DES in treatment of fast progressing atherosclerosis population as in DM patients.
Trial registration NTR5447. Registered 05 October 2015, retrospectively registered