bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetically Actuated Microrobot Equipped with Electron‐Extracting Nanohooks for Enhanced Photothermal Fungal Eradication
Authors: Tang Zhuoyun , Kang Yong , Tang Haiyang , Li Qian , Qu Wei , Ji Xiaoyuan , Xia Dehua 
Published: December 2024

AbstractFungal infections pose a formidable challenge in the healing of diabetic wounds due to complex inflammatory microenvironments, high resistance, and recurrence risks, particularly during fungal aggregation and germination stages. Inspired by controllable fishhooks, this work presents a magnetically actuated microrobot (Co@NCNH/NC) that leverages carbon nanohooks to enhance localized photothermal therapy. This microrobot features controllable navigation capabilities to pathogens in the magnetic field, enabling precise fungal capture and thermally promoted penetration even in high‐viscosity environments. With impact force and high conductivity, the microrobot's nanohooks induce disruption of cell envelopes and facilitate electron extraction from membranes, collectively compromising fungal integrity and enhancing fungal vulnerability. Thus, in situ, heat ablation further eradicates aggregated spores and causes irreversible damage to germinated fungi by aggravating cellular lysis, metabolic dysfunction, and destruction of actin cytoskeletons, inhibiting fungal self‐repair and growth. Moreover, Co@NCNH/NC with good biocompatibility exhibits catalase‐like activity that helps alleviate wound inflammation during therapy. This dual‐action approach accelerates critical wound healing processes including angiogenesis and epidermalization, ultimately improving healing outcomes in chronic diabetic wounds. By combining targeted fungal eradication with inflammation reduction and tissue regeneration, this adaptable microrobotic technology shows considerable promise for advancing therapeutic efficacy and prevention of recurrence in diabetic wound healing.
Self‐Driven Janus Ga/Mg Micromotors for Reducing Deep Bacterial Infection in the Treatment of Periodontitis
Authors: Chi Hang , Wu Wei , Bao Hongxia , Wu Yingjie , Hu Narisu 
Published: December 2024

AbstractA self‐propulsion Janus gallium (Ga)/magnesium (Mg) bimetallic micromotor is designed with favorable biocompatibility and antimicrobial properties as a therapeutic strategy for periodontitis. The Janus Ga/Mg micromotors are fabricated by microcontact printing technique to asymmetrically modify liquid metallic gallium onto magnesium microspheres. Hydrogen bubbles produced by the magnesium‐water reaction can provide the driving performance of up to 31.03 µm s−1 (pH 6.8), prompting the micromotor to actively breakthrough the biological barrier of saliva and gingival crevice fluid (GCF) into the bottom of periodontal pockets. In addition, the Janus Ga/Mg micromotors are effectively converted by degradation into the built‐in antimicrobial ion Ga(III) to eliminate deep‐seated Porphyromonas gingivalis (P.gingivalis), with bactericidal efficiencies of over 99.8%. The developed Janus Ga/Mg micromotors have demonstrated potent antimicrobial and anti‐inflammatory activity both in vitro and in vivo studies. Crucially, it reduces alveolar bone resorption, demonstrating the superior efficacy of liquid metal gallium in treating periodontitis. Therefore, Ga/Mg bimetallic micromotors hold great promise to be an innovative and translational drug delivery system to treat periodontitis or other inflammation‐related diseases in the near future.
Recent Advances in the Synthesis and Application of TS‐1 Zeolite for Green Catalytic Oxidation
Authors: Wang Jiawen , Duan Ning , Li Pan , Liu Yanyan , Wu Xianli , Li Baojun 
Published: December 2024

AbstractTS‐1 has a unique structure, and TS‐1/H2O2 oxidation system for composition shows excellent catalytic performance in the oxidation of a variety of organic matter. The response conditions of the reaction system are mild, and the ultimate oxidation product is water. It is a typical “green catalytic” system and has received widespread attention from researchers. Here, the synthesis progress of TS‐1 to improve the accessibility and activity of active sites by doping mesoporous and microporous structures into traditional TS‐1 zeolite in recent five years are reviewed, including hydrothermal synthesis, dry gel conversion synthesis, solvent‐free synthesis, microwave assisted synthesis, and isomorphous substitution. Meanwhile, the application of TS‐1/H2O2 system in oxidative desulfurization, ketone ammonia oxidation, olefin epoxidation, and hydroxylation of aromatic hydrocarbons reactions are summarized and discussed. What's more, the reaction mechanism based on TS‐1/H2O2 system is proposed on regarding the isolated skeleton Ti site in titanium‐silicon zeolite as the active central site. Finally, the challenges and future development prospects of TS‐1 zeolite in synthesis and catalytic applications are predicted.
Streamlined Phase Transition and Reaction Compensation in Hybrid Evaporation‐Solution Deposited Inverted Perovskite Solar Cells
Authors: Wang Jiahao , Zhou Yuan , Ai Wei , Pu Dexin , Fang Hongyi , Fu Shiqiang , Guan Hongling , Shao Wenlong , Chen Guoyi , Meng Weiwei , Fang Guojia , Ke Weijun 
Published: December 2024

AbstractPerovskite solar cells (PSCs) represent a promising technology for next‐generation photovoltaics, yet scaling up from laboratory to industrial production via the solution spin‐coating method encounters significant challenges. Vacuum deposition offers a potential alternative but struggles with controlling perovskite phases and ensuring sufficient precursor reactions. Here, the study presents a hybrid evaporation‐solution approach using a large cation‐based pseudo‐halogen anion salt (guanidine thiocyanate) and a compensating cation salt (methylammonium iodide) as co‐additives to finely modulate the phase transition process. This approach eliminates the need for intermediate‐phase transitions, promotes sufficient precursor reactions, and facilitates the formation of highly oriented α‐phase perovskites prior to annealing. Consequently, it prevents detrimental δ‐phase formation, yielding enlarged, homogeneous perovskite grains with significantly reduced defects. The resulting p‐i‐n‐structured PSCs achieve a maximum efficiency of 24.72% and a low open‐circuit voltage loss of 0.377 V, coupled with significantly improved stability. The work integrates the advantages of vacuum deposition and solution processing, providing new insights into perovskite phase transitions and paving the way for the efficient, scalable production of high‐performance PSCs.
Beyond Molecular Design: Cocrystallization in Hydrogen‐Bonded Organic Frameworks for Energy‐Conserving Dehydration and Real‐Time Luminescent Humidity Detection
Authors: Sun Wen‐Zhu , Zhang Wei‐Jie , Xu Ji‐Tong , Liu Dan‐Qing , Ou Bei‐Qi , Chen Ling , Ye Jia‐Wen , Chen Xiao‐Ming 
Published: December 2024

ABSTRACTLuminescent probes attract increasing attentions for the unique superiorities like visually real‐time detecting. However, for optical humidity sensing, it is still quite challenging to attain facile dehydration/activation in sensing materials, due to the high polarity of water molecules, which limits their applications in real‐time detection and energy‐conserving applications. Here, we report two fluorescent hydrogen‐bonded organic frameworks (HOFs), HPISF‐H2O and TPISF. HPISF‐H2O achieves water absorption in low humidity, but needs an energy‐intensive step (heating to ∼92°C in air) to dehydrate. Conversely, despite only a hydroxyl group being replaced, TPISF cannot bind to H2O at all. In other words, real‐time detection is not readily achieved through straightforward molecular design. Therefore, we propose a cocrystallization strategy to adjust their water‐binding capacity. As a result, the HOF cocrystals are adjusted to have both good H2O absorptivity and very gentle desorbing operation without heating (dry gas blowing or vacuuming). Benefiting from this strategy, appreciable advantages for an effective humidity sensor are realized, including real‐time detection (second‐scale response/recovery) and distinguishing fluorescence variation. Efficient sensing across a broad relative humidity (RH) range (10.0%–80.0%) was further achieved. Moreover, the mechanistic insight of fluorescent sensing was ascertained through detailed analyses of structural transformation, spectroscopic data, and theoretical approach.
Reconfigurable CMOS‐Compatible Supercapacitor‐Diode Empowering Computation Efficiency for Human‐Machine Interaction
Authors: Wang Dong , Yang Bofan , Zhou Ziye , Zhang Zhihan , Wu Zhengxiao , Huang Xiaodong 
Published: December 2024

AbstractBiological system utilizes unidirectional ion flow to produce and transmit signals. To realize bioinspired artificial intelligence and thus seamless human‐machine interaction, ion rectification devices should be developed. Here, a reconfigurable CMOS‐compatible supercapacitor‐diode (CAPode) is developed by resettling the pseudo‐capacitive and electrochemical‐double‐layer‐capacitive components of a lithium‐ion pseudocapacitor into the positive and negative voltage regions respectively through engineering the redox peaks. This CAPode exhibits good ion rectification and charge‐storage bifunction with high rectification ratio (RR) (RRI~20, RRII~0.83), large areal capacitance (17 mF cm−2) and long cycling stability (5000 cycles). More importantly, two main computing paradigms in the biological system are efficiently realized based on this CAPode by empowering the supercapacitor function into the diode: (I) multivalued ionic logic gates are constructed based on the tunable ion rectification characteristics induced by the bifunction of this CAPode for mimicking the dendritic computing; (II) all‐CAPode based reservoir computing is implemented based on the reconfigurable volatile and nonvolatile charge‐storage characteristics of this CAPode for mimicking the neuromorphic computing. This work paves a new way towards seamless and high‐efficiency human‐machine interaction.
Promoting Alcohols Electrooxidation Coupled with Hydrogen Production via Asymmetric Pulse Potential Strategy
Authors: Xia Tian , Yang Jiangrong , Ren Qinghui , Fu Yu , Zhang Zhiyuan , Li Zhenhua , Shao Mingfei , Duan Xue 
Published: December 2024

AbstractElectrocatalytic organic oxidation coupled with hydrogen (H2) production emerges as a profitable solution to simultaneously reduce overall energy consumption of H2 production and synthetic high‐value chemicals. Noble metal catalysts are highly efficient electrocatalysts in oxidation reactions, but they deactivate easily weakening the benefit in actual production. Herein, we report a universal asymmetric pulse potential strategy to achieve long‐term stable operation of noble metals for various alcohol oxidation reactions and noble metal catalysts. For example, by pulsed potentials between 0.8 V and 0 V vs. RHE, palladium (Pd)‐catalyzed glycerol (GLY) electrooxidation can continuously proceed for more than 2800 h with glyceric acid (GLA) selectivity of >70 %. Whereas, Pd electrocatalyst becomes nearly deactivated within 6 h of reaction under conventional potentiostatic strategy. Experimental and theoretical calculation results reveal that the generated electrophilic OH* from H2O/OH− oxidation on Pd (denoted as Pd−OH*) acts as main active species for GLY oxidation. However, Pd−OH* is prone to be oxidized to PdOx resulting in performance decay. When a short reduction potential (e.g., 0 V vs. RHE for 5 s) is powered, PdOx can be reversibly reduced to restore the current. Moreover, we tested the feasibility of this strategy in a flow electrolyzer, verifying the practical application potential.
Phthalimide derivatives as a new class of papain‐like protease inhibitors in SARS‐CoV‐2
Authors: Fischer Thomas , Frasson David , Sievers Martin , Riedl Rainer 
Published: December 2024

AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) papain‐like cysteine protease (PLpro) represents one of only two essential cysteine proteases involved in the regulation of viral replication. It, therefore, qualifies as a promising therapeutic target for the development of antiviral agents. We identified a previously synthesized protease inhibitor, resulting from an earlier project, as a PLpro inhibitor and crafted a structure–activity relationship around the hit, leading to the more potent inhibitors ZHAWOC6941 (17h) and ZHAWOC25153 (17o) displaying IC50 values of 8 and 7 µM, respectively. The two compounds represent a new class of PLpro inhibitors and, with single‐digit micromolar IC50 values, are comparable to inhibitors found in the literature.
Bauakustische Simulation einer Holzrahmenwand
Authors: Stenitzer Alexander , Neusser Maximilian , Nusser Bernd 
Published: December 2024

AbstractBauphysikalische Simulationen haben sich im Planungsalltag der Hygrothermik bereits fest etabliert. Die Simulation realer physikalischer Effekte in der Bauakustik, speziell im Leichtbau, und die Möglichkeit, präzise Vorhersagen zu treffen, stellt bisher aber noch eine Herausforderung dar. Mit zunehmender Nachfrage im Holzbau wachsen die Ansprüche sowie der Bedarf an Planungssicherheit. Die zuverlässige frequenzabhängige Prognose des Schalldämmmaßes von Leichtbauteilen könnte ressourcenintensive Messungen einsparen. Bisher hat sich die Finite Elemente Methode (FEM) als geeignete Methode erwiesen, um bauakustische Parameterstudien an Leichtbauteilen durchzuführen und konstruktive Veränderungen in Relation zueinander zu bewerten. In diesem Artikel wird die Simulation einer Holzrahmenwand in Fenstergröße mithilfe der FEM präsentiert. Die Simulationsergebnisse, durchgeführt mit der Software „COMSOL Multiphysics 6.1“, werden mit bauakustischen Messungen verglichen. Das Schalldämmmaß wird mit einer maximalen Abweichung von 5 dB pro Terzband prognostiziert. Bei der FEM ist die Qualität der Eingangsdaten entscheidend, wobei durch Modalanalysen relevante Steifigkeitswerte und Verlustfaktoren ermittelt werden. Dieser Ansatz gewinnt insbesondere bei mehrschichtigen Bauteilen mit anisotropen Materialien an Relevanz. Zusätzlich zur Modellvalidierung wurden anhand des Modells unterschiedliche Parametervariationen durchgeführt, deren Ergebnisse ebenfalls detailliert dargelegt werden.
Naturally Occurring Cleistanthane Diterpenoids and Their Biological Activities
Authors: Yang Hong‐Ying , He Yi‐Lin , Chen Jian‐Jun , Gao Kun 
Published: December 2024

ABSTRACTCleistanthane diterpenoids, an important class of active natural products, are characterized by a 6/6/6 tricycle system and contain a variety of functional groups. Studies have shown that cleistanthane diterpenoids are widespread in various higher plants and endophytic fungi and exhibit a wide range of biological activities. This review provides extensive coverage of naturally occurring cleistanthane diterpenoids discovered from 1973 to 2024 and sheds light on the sources, structures, biological effects, and primary molecular mechanisms of them and provides a useful reference for the further study and development of these compounds.
Conservative Management of Horizontal Root Fracture: A Case Report
Authors: Haghdadi Farid , Mokabberi Amirreza , Rad Seyed Ahmad Banihashem 
Published: December 2024

ABSTRACTIn cases where permanent teeth have closed apices and completely erupted roots, the probability of root fractures is increased due to the stable support given by the adjacent bone and periodontal tissues. Fractures have the potential to affect several dental structures, including the pulp, dentin, cementum, bone, and periodontal tissues. In cases of horizontal root fractures (HRF), the apical section typically maintains vitality; however, the present case presented an unusual apex necrosis. Given the patient's age and tooth stability, traditional apical surgery was deemed inappropriate. Instead, a conservative treatment approach was chosen to preserve the tooth. This case report details the management and a 2‐year follow‐up of a maxillary central incisor exhibiting a HRF and apical necrosis, successfully addressed through the application of Mineral Trioxide Aggregate (MTA) in the both apical and coronal segments. Using MTA prevented apical surgery in cases of apex necrosis accompanied by HRF.
Systemic‐to‐Pulmonary Collateral Artery in a Preterm Infant
Authors: Shitara Yoshihiko , Furuya Tomoko , Kondo Utako , Kushima Reiko 
Published: December 2024

ABSTRACTThis case involved the detection of a systemic‐to‐pulmonary collateral artery (SPCA) in a preterm infant at 18 days using echocardiography, with SPCA closure identified at 11 months. Regular echocardiographic monitoring is essential to prompt therapeutic intervention in cases of elevated pulmonary flow, emphasizing the importance of timely management.
Cu/ZnO/Al2O3 Catalyst Promoted with Amorphous MgO for Enhanced CO2 Hydrogenation to Methanol
Authors: Chen Hecao , Xie Shangzhi , Jiang Zhaocong , Xu Jing , Zhu Minghui 
Published: December 2024

AbstractCO2 hydrogenation to methanol not only reduces CO2 emissions but also produces a high‐quality energy source that is easy to store and transport. We found that the Cu/ZnO/Al2O3/MgO catalyst prepared by the deposition‐precipitation method, exhibits a higher methanol space‐time yield compared to the Cu/ZnO/Al2O3 catalyst below 2 MPa. However, no activity difference was observed beyond 2 MPa. Characterization techniques revealed that for the Cu/ZnO/Al2O3/MgO catalyst, MgO is amorphous attributed to the influence of Al during calcination. The presence of amorphous MgO not only reduces the size of Cu0 particles but also enhances CO2 adsorption on the catalyst surface. We also demonstrate that improvement of CO2 adsorption capacity is the key factor for the higher activity of the Cu/ZnO/Al2O3/MgO catalyst below 2 MPa.
Gold Nanoparticle‐Catalyzed Solvent Switchable Selective Partial Reduction of Nitrobenzene to N‐Phenylhydroxylamine and Azoxybenzene
Authors: Doherty Simon , Knight Julian G. , Alharbi Hussam Y. , Paterson Reece , Wills Corinne , Dixon Casey , Chamberlain Thomas W. , Yan Han , Griffiths Anthony , Daly Helen , Chansai Sarayute , Hardacre Christopher 
Published: December 2024

AbstractImpregnation of phosphine‐decorated polymer‐immobilized ionic liquid with the tetrachloroaurate anion results in reduction of the gold(III) to gold(I) with concomitant oxidation of the phosphine to its oxide. In situ reduction of the resulting precursor, AuCl@O = PPh2‐PEGPIILS, generated the corresponding O = PPh2‐PEGPIIL‐stabilized AuNPs, AuNP@O = PPh2‐PEGPIILS, which is a highly active and selective catalyst for the solvent‐dependent partial reduction of nitrobenzene to N‐phenylhydroxylamine in water and azoxybenzene in ethanol. The initial TOFs are comparable to those obtained with gold nanoparticles generated by reduction of tetrachloroaurate‐impregnated phosphine oxide‐decorated polymer‐immobilized ionic liquid AuCl4@O = PPh2‐PEGPIILS, i.e., the activity and selectivity profiles do not appear to depend on whether the AuNPs are generated from Au(III) or in situ‐generated Au(I). In stark contrast, gold nanoparticles prepared by NaBH4 reduction of AuCl@PPh2‐PEGPIILS based on gold(I) confined in phosphine‐modified polymer‐immobilized ionic liquid gave markedly lower initial TOFs. The use of dimethylamine borane (DMAB) as the hydrogen donor resulted in a substantial and dramatic enhancement in activity for reductions conducted in water compared with NaBH4 and the initial TOF of 20,400 mol nitrobenzene converted mol Au−1 h−1 obtained with AuNPs generated in situ from AuCl4@O = PPh2‐PEGPIILS is among the highest to be reported for the metal nanoparticle catalyzed selective reduction of nitrobenzene to N‐phenylhydroxylamine; this is a significant improvement on existing protocols, which should enable the partial selective reduction of nitroarenes to be conducted in water with a low catalyst loading under extremely mild conditions.
Investigation of the Effects of Blocking Potassium Channels With 4‐Aminopyridine on Paclitaxel Activity in Breast Cancer Cell Lines
Authors: Cüce‐Aydoğmuş Esra M. , İnhan‐Garip G. Ayşe 
Published: December 2024

ABSTRACTBackgroundPaclitaxel (PTX) has been used as a chemotherapeutic agent for several malignancies, including breast cancer, and efforts to increase the efficiency of PTX are continuous. Previous studies have shown that the voltage‐gated K+ channels are over‐expressed in breast cancer cell lines; therefore, blocking this type of K+ channel reduces cell proliferation and viability.AimsIn this study, FDA‐approved 4‐aminopyridine (4‐AP), a voltage‐gated potassium channel blocker, was used in combination with PTX to improve the anticancer activity of PTX in MCF‐7 and MDA‐MB‐231 cell lines.Methods and ResultsViability was determined with trypan blue, a clonogenic assay was performed, and the cell cycle was determined with a flow cytometer and immunochemistry. To gain an insight into the mechanism, intracellular K+ concentration, intracellular Ca2+ (calcium) concentration, and transmembrane potential measurements were made with corresponding fluorescent dyes. The apoptotic cell number was determined using Annexin /PI method by flow cytometer. Viability decreased with combination therapy and the clonogenic assay proved decreased colony formation. The apoptotic cell number was increased after treatment with the combination in both cell lines. Cell cycle measurements showed G1 arrest for both MCF‐7 and MDA‐MB‐231 cell lines upon 4‐AP treatment. PTX caused G1 arrest in MCF‐7 cells and S phase arrest in MDA‐MB‐231 cells. Combination treatment caused S phase arrest in MCF‐7 cells and S phase and G2/M phase arrest in MDA‐MB‐231 cells. Intracellular K+ concentration was increased after all treatments in both cell lines. Ca2+ concentration was increased significantly after combination treatment. Depolarization in the transmembrane potential was observed after all treatments in both cell lines.ConclusionBiophysical parameters like the transmembrane potential and ion fluxes have been defined in cancer progression which can provide new aspects for cancer treatments. This study shows that the combination of 4‐AP with PTX is a promising alternative the mechanism of which needs further investigation considering the results obtained for Ca2+, K+, and membrane potential.
Microbial Upgrading of Lignin Depolymerization: Enhancing Efficiency with Lignin‐First Catalysis
Authors: Ponukumati Aditya , Carr Rhiannon , Ebrahimpourboura Zahra , Hu Yifeng , Narani Anand , Gao Yu , Shang Zeyu , Krishnamurthy Anirudh , Mba Wright Mark , Seok Moon Tae , Foston Marcus 
Published: December 2024

AbstractChemical depolymerization of lignin is a non‐selective process that often generates a wide distribution of product compounds, denoted herein as lignin breakdown products (LBPs). To address this limitation, we developed a hybrid lignin conversion process that employs a lignin‐first catalytic approach on biomass and subsequent microbial upgrading. A Pd/C catalyst was used for reductive catalytic fractionation (RCF) of poplar biomass, and Rhodococcus opacus PD630 (R. opacus PD630) was then cultivated on the resulting LBPs. This RCF approach increases the total biomass utilization by R. opacus PD630 over base‐catalyzed depolymerization (BCD) reactions that were performed in the absence of Pd/C and molecular hydrogen (H2). LBPs generated using RCF resulted in higher cell growth per gram of biomass. Cellulose in the residual biomass after RCF treatment also showed enhanced enzymatic digestibility due to saccharification yields over 40%. Techno‐economic analysis (TEA) and life cycle analysis (LCA) of this hybrid lignin conversion scheme, integrated into a cellulosic bioethanol plant, decreased the minimum ethanol selling price from $4.07/gallon (base case) to $3.94/gallon. Global warming potentials ranged from 29 and 30.5 CO2,eq/MJ. These results highlight the potential for an industrial hybrid conversion‐based biorefinery scheme that utilizes lignin‐first catalytic deconstruction and R. opacus PD630 upgrading.