bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualization of Genomic Loci in Living Cells with BiFC‐TALE
Authors: Hu Huan , Yang Xiaojing , Tang Chao 
Published: October 2018

AbstractTracking the dynamics of genomic loci is essential for understanding a variety of cellular processes. However, earlier methods have all suffered from a low signal‐to‐background ratio (SBR), mainly caused by the background fluorescence from diffuse full‐length fluorescent proteins in the nucleus. We have developed a novel method (BiFC‐TALE) for labeling and tracking genomic loci in live mammalian cells, combining bimolecular fluorescence complementation (BiFC) and transcription activator–like effector (TALE) technologies. Since only the sequences‐targeted BiFC fragments can be pulled together by TALE modules to recombine intact fluorescent proteins, the background fluorescence in the living nucleus can be largely reduced, which significantly improves SBR. Using telomere and centromere labeling as examples, this unit describes in detail the design and implementation of BiFC‐TALE system. © 2018 by John Wiley & Sons, Inc.
What makes consumers respond to creating shared value strategy? Considering consumers as stakeholders in sustainable development
Authors: Nam Su‐Jung , Hwang Hyesun 
Published: October 2018

AbstractCreating shared value is a strategic approach for sustainable development connected to social value that moves away from a corporation's profit and competition‐oriented strategies. This study examines consumers' responses, including attitudes and intentions to participate in a strategy creating shared value by applying the persuasion knowledge model. Results reveal that consumers formed positive attitudes mainly through persuasive knowledge, which led to higher intentions to participate in creating the shared value strategy. This study also provides evidence for the role of consumers' propensity for socially responsible consumption, and intentions became stronger when consumers had a strong propensity for socially responsible consumption. This study elaborates on the discussion around corporations' strategies for achieving a sustainable society through social‐centric corporate strategies that can be developed by reconciling corporate and consumer morality in the marketplace.
The relationship between cognitive enrichment and cognitive control: A systematic investigation of environmental influences on development through socioeconomic status
Authors: Amso Dima , Salhi Carmel , Badre David 
Published: October 2018

AbstractWe measured the impact of socioeconomic status (SES) on cognitive processes. We examined cognitive control, specifically working memory (WM), in a sample of N = 141 7‐ to 17‐year‐olds using rule‐guided behavior tasks. Our hypothesis is based on computational modeling data that suggest that the development of flexible cognitive control requires variable experiences in which to implement rule‐guided action. We found that not all experiences that correlated with SES in our sample impacted task performance, and not all experiential variables that impacted performance were associated with SES. Of the experiential variables associated with task performance, only cognitive enrichment opportunities worked indirectly through SES to affect WM as tested with rule‐guided behavior tasks. We discuss the data in the context of necessary precision in SES research.
The measurement and quantification of generalized gradients of soil fertility relevant to plant community ecology
Authors: Daou Laurent , Shipley Bill 
Published: October 2018

AbstractWe propose an operational definition of soil “fertility” that is applicable to plant community ecology and develop a method of measuring and quantifying it, using structural equations modeling, that is generalizable to soils in different regions whose fertility has different causes. To do this, we used structural equation modeling (SEM). The measurement submodel predicts the latent “generalized fertility,”FG, of a soil using four indicator variables: the relative growth rates ofFestuca rubra,Trifolium pratense,Triticum aestivum, andArabidopsis thaliana. The direct causes ofFGin this study were the supply rates of NO3−, P, and K as well as three indirect causes consisting of three physical soil properties, but these can change between studies. The model was calibrated using 76 grassland soils from southern Quebec, Canada and independently tested using aboveground net primary productivity (NPP) of the natural vegetation over two growing seasons. Both the measurement submodel and the full SEM fit the data well. TheFGvalues predicted 51% of the variance in NPP and were a better predictor than any other single variable, including the actual nutrient flux rates. Furthermore, this model can be applied to grassland soils anywhere because of its modular nature in which the causes and effects of soil fertility are clearly separated.
Sn‐based Intermetallic Compounds for Li‐ion Batteries: Structures, Lithiation Mechanism, and Electrochemical Performances
Authors: Yi Zheng , Wang Zhaomin , Cheng Yong , Wang Limin 
Published: October 2018

On account of the lower theoretical capacity of the traditional graphite, the development of reliable anode materials with high capacity and energy density for application in lithium‐ion batteries (LIBs) is zealously pursued to meet the ever‐increasing power demands for portable mobile devices or (hybrid) electronic vehicles. Recently, Sn‐based intermetallic compounds have attracted considerable research interests as the promising candidate anode materials for high‐performance LIBs in consideration of the high theoretical capacity of Sn (994 mAh g−1) and low operating voltage (below 0.6 V vs Li+/Li). The fabrication of Sn‐based intermetallic compounds is aiming at buffering the huge volumetric variation of Sn anode during lithiation/delithiation processes. Therefore, the rational construction of those anode materials with enhanced electrochemical performance is meaningful. This review is focusing on sum up the recent development in the structures, lithiation mechanism and electrochemical performances of various Sn‐based intermetallic compounds as anode materials in LIBs. The developments of modified methods for further enhancement of lithium storage performances of Sn‐based intermetallic compounds are also systematically summarized. We hope this review could provide a fundamental understanding of the Sn‐based intermetallic compounds for the application in LIBs.
May a sigma‐1 antagonist improve neuropathic signs induced by cisplatin and vincristine in rats?
Authors: Paniagua Nancy , Goicoechea Carlos , Abalo Raquel , López‐Miranda Visitacion , Vela J. Miguel , Merlos Manuel , Martín Fontelles María Isabel , Girón Rocio 
Published: October 2018

AbstractBackgroundThe antineoplastic drugs cisplatin and vincristine induce peripheral neuropathies. The sigma‐1 receptor (σ1R) is expressed in areas of pain control, and its blockade with the novel selective antagonist MR‐309 has shown efficacy in nociceptive and neuropathic pain models. Our goal was to test whether this compound reduces neuropathic signs provoked by these antitumoural drugs.MethodsRats were treated with cisplatin or vincristine to induce neuropathies. The effects of acute or repeated administration of MR‐309 were tested on mechanical and thermal sensitivity, electrophysiological activity of Aδ‐primary afferents in the rat skin–saphenous nerve preparation, and gastrointestinal or cardiovascular functions.ResultsRats treated with antitumourals developed tactile allodynia, while those treated with vincristine also developed mechanical hyperalgesia. These in vivo modifications correlated with electrophysiological hyperactivity (increased spontaneous activity and hyperresponsiveness to innocuous and noxious mechanical stimulation). Animals treated with cisplatin showed gastrointestinal impairment and those receiving vincristine showed cardiovascular toxicity. A single dose of MR‐309 strongly reduced both nociceptive behaviour and electrophysiological changes. Moreover, its concomitant administration with the antitumourals blocked the development of neuropathic symptoms, thus restoring mechanical sensitivity, improving the impairment of feeding behaviour and gastrointestinal transit in the cisplatin‐treated group along with ameliorating the altered vascular reactivity recorded in rats treated with vincristine.Conclusionσ1R antagonist, MR‐309, reduces sensorial and electrophysiological neuropathic signs in rats treated with cisplatin or vincristine and, in addition, reduces gastrointestinal and cardiovascular side effects.Significanceσ1R antagonism could be an interesting and new option to palliate antitumoural neuropathies.
Comparison of mathematical models to predict glass transition temperature of rice (cultivar IRGA 424) measured by dynamic mechanical analysis
Authors: Bertotto M. Mercedes , Gastón Analía , Rodríguez Batiller María J. , Calello Pablo 
Published: October 2018

AbstractDynamic mechanical analysis (DMA) was applied to measure the Tg of rice IRGA 424 at different moisture content values (9.3%–22.3% wet basis). To conduct temperature sweeps, the samples were heated at a rate of 2°C/min from 20 to 120°C keeping frequency to 1 Hz. Tg was measured both from the E″ peak temperature (Tgmidpoint) and from the tan (δ) peak temperature (Tgendset). Tgmidpoint and Tgendset increased from 31.8 to 86.6°C and 42.1 to 104.7°C, respectively, as moisture content decreased from 22.3 to 9.3%. Six models were tested for their ability to predict Tg as a function of the moisture content. As all residuals were normally distributed and homoskedastic, standard metrics were used to assess the fitted models. Goodness of fit by these models was established by comparing the coefficient of determination (R2), standard error of the estimate (SEE), and mean relative deviation (MRD). The Gordon–Taylor linearized equation was the most accurate in predicting Tg. To predict Tg from the moisture content of the rice samples, a new expression was proposed. For the conditions considered in this work, the developed equation satisfactorily predicts the Tg of rice IRGA 424 without needing prior linearization.
Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma
Authors: Yasumatsu Ryuji , Nakano Takafumi , Sato Masanobu , Jiroumaru Rina , Hashimoto Kazuki , Kogo Ryunosuke , Wakasaki Takahiro , Nakashima Torahiko , Nakagawa Takashi 
Published: October 2018

AbstractBackgroundDifferentiating inverted papilloma from squamous cell carcinoma (SCC) is sometimes difficult. We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with inverted papilloma or SCC.MethodsSerum and tissue samples for the analysis of SCCA1, SCCA2, and SCC antigen were taken from 18 patients with sinonasal inverted papilloma and 23 cases with sinonasal SCC. The SCCA1, SCCA2, and SCC antigen levels were determined.ResultsThe serum SCCA1 concentration was significantly higher in the inverted papilloma group than in the SCC group, whereas the serum SCCA2 level was significantly higher in the SCC group than in the inverted papilloma group.ConclusionPatients with sinonasal inverted papilloma predominantly express SCCA1 protein, whereas those with SCC predominantly express SCCA2. This suggests that combined measurements of both serum SCCA1 and SCCA2 concentrations can be very useful for distinguishing sinonasal inverted papilloma from SCC.
Response of low flows under climate warming in high‐altitude permafrost regions in western China
Authors: Wang Xiqiang , Chen Rensheng , Liu Guohua , Han Chuntan , Yang Yong , Song Yaoxuan , Liu Junfeng , Liu Zhangwen , Liu Xiaojiao , Guo Shuhai , Wang Lei , Zheng Qin 
Published: October 2018

AbstractThe increase in low flows (winter discharge and minimum monthly discharge), caused primarily by permafrost degradation, is common in high‐latitude permafrost regions, whereas the dynamics of low flows in high‐altitude permafrost regions remain largely unknown. Long‐term discharge data from 28 unregulated catchments in western China were analysed, and the findings showed that winter discharge/minimum monthly discharge significantly increased (p ≤ 0.1) in 82/82%, 55/64%, and 0/0% of the catchments in the higher‐latitude mountain permafrost regions (Tienshan Mountains), mid‐latitude mountain permafrost regions (Qilian Mountains), and mid‐ to low‐latitude plateau permafrost regions (the source regions of the Yangtze and Yellow rivers), respectively. The differences in permafrost type and the distribution of permafrost and alpine cold desert (which is similar to tundra) were found to be the main causes for the different responses in the low flows. The rate of change of low flows (winter discharge and minimum monthly discharge) was negatively and linearly correlated with permafrost coverage when coverage was less than 40% of the catchment area, whereas the low flows changed only slightly when the permafrost coverage exceeded 40%. A significant thickening of the active layer increased the low flows in the lower permafrost‐covered catchments, which are dominated by warm permafrost. However, in the higher permafrost‐covered catchments with cold permafrost and a cold climate, only an increase in permafrost temperature (without a notable thickening of the active layer) occurred, resulting in non‐significant changes in low flows.
Evaluation of trends and predictability of short‐term droughts in three meteorological subdivisions of India using multivariate EMD‐based hybrid modelling
Authors: Adarsh Sankaran , Janga Reddy Manne 
Published: October 2018

AbstractThis paper presented trend analysis of droughts in Kerala, Telangana, and Orissa meteorological subdivisions in India and proposed a framework for drought prediction by employing the Empirical Mode Decomposition (EMD)‐based prediction models. The study used 3‐month standardized precipitation index (SPI3) for drought analysis. The trend analysis of SPI3 series for the period 1871–2012 using Mann–Kendall method showed statistically significant increasing trend in Kerala and Telangana subdivisions and a decreasing trend in Orissa subdivision. In addition, the non‐linear trend component extracted from EMD showed statistically significant changes in all the three subdivisions. Then, the study proposed a hybrid approach for prediction of short‐term droughts by coupling multivariate extension of EMD (MEMD) with stepwise linear regression (SLR) and genetic programming (GP) methods. First, the multivariate dataset comprising the SPI3 series of current and lagged time steps are decomposed using the MEMD. Then, SLR/GP models are developed to predict each subseries of SPI3 of desired time step considering the subseries of predictor variables at the corresponding timescales as inputs. The resulting models at different timescales are recombined to obtain the SPI3 values of the desired time step. The method is applied for prediction of short‐term droughts in the three subdivisions. The results obtained by the hybrid models are compared with that obtained by conventional prediction models using M5 Model Trees and GP. The rigorous performance evaluation based on multiple statistical criteria clearly exhibited the superiority of the hybrid approaches (i.e., prediction models with MEMD‐based decomposition over models without decomposition) for prediction of SPI3 in three subdivisions. Further, the study found that MEMD‐GP model performs marginally better than the MEMD‐SLR model due to its efficacy in modelling high frequency modes.
Differences in sensory responses among children with autism spectrum disorder and typical development: Links to joint attention and social competence
Authors: Dakopolos Andrew J. , Jahromi Laudan B. 
Published: October 2018

AbstractThe current study investigated relations among children's sensory responses, dyadic orienting, joint attention, and their subsequent social competence with peers. Participants were 38 children (18 children with autism spectrum disorder [ASD] and 20 developmentally matched children with typical development) between the ages of 2.75 and 6.5 years. Observational coding was conducted to assess children's joint attention and dyadic orienting in a structured social communication task. Children's sensory responses and social competence were measured with parent report. Group differences were observed in children's joint attention, sensory responses, multisensory dyadic orienting, and social competence, with the ASD group showing significantly greater social impairment and sensory responses compared with their typical peers. Atypical sensory responses were negatively associated with individual differences on social competence subscales. Interaction effects were observed between diagnostic group and sensory responses with diagnostic group moderating the relation between sensory responses and both joint attention and social competence abilities.Highlights

We explored patterns of relations between sensory responses, social competence, and joint attention among preschoolers with high functioning autism and typical development.
Differential relations were found between sensory responses, social competence, and joint attention for children with autism compared with those with typical development.
Individuals with ASD may process sensory stimuli differently compared to individuals with TD.
Using spatial and temporal variability data to optimize sediment toxicity identification evaluation (TIE) study designs
Authors: Greenstein Darrin J , Parks Ashley N , Bay Steven M 
Published: October 2018

Abstract

Toxicity tests are an important aspect of sediment quality assessments, but knowledge of the cause of toxicity is needed to determine effective management actions. Toxicity identification evaluation (TIE) methods were developed to meet this need. While TIE method manuals provide information on the procedures, little information on study design is presented. The level of variability associated with performing TIEs and how to account for it is also not addressed. The goal of this study was to collect data on both the spatial and temporal variability associated with sediment TIEs by use of the amphipod Eohaustorius estuarius 10-day survival test and then apply that information to make recommendations for designing future TIE studies. Ten stations were sampled at Consolidated Slip in Los Angeles Harbor, California, with samples collected 2 months apart. In the first stage, TIEs were conducted on whole sediment and pore water from 3 of the most toxic stations. In the second stage, focused TIEs were conducted on whole sediment from all stations. Chemical analysis for metals and organic contaminants was also performed. With a weight of evidence approach, it was determined that pyrethroid pesticides were the likely cause of toxicity, with a lesser contribution from polycyclic aromatic hydrocarbons (PAHs). Results of the individual TIEs fell into 3 broad categories: TIEs in which treatments for organic chemicals and pyrethroids were effective; TIEs in which the treatment for pyrethroids was not effective but the treatment for organic contaminants was effective; and TIEs in which the treatment for pyrethroids was effective but the treatment for organic contaminants was not. This variability was used to calculate that at least 3 TIEs were necessary to make a confident assessment of the cause of toxicity. There was not substantial temporal variability in the TIE outcomes. Other recommendations are made regarding effective TIE study design. Integr Environ Assess Manag 2019;15:248–258. © 2018 SETAC
Conducting Polymer Nanostructures and their Derivatives for Flexible Supercapacitors
Authors: Cheng Meng , Meng Yue‐Na , Wei Zhi‐Xiang 
Published: October 2018

AbstractThis review provides a brief summary of the recent research developments in the fabrication and application of conducting polymer nanostructures and their derivatives as electrodes for flexible supercapacitors (SCs). By controlling the nucleation and growth process of polymerization, conducting polymers (CPs) with different nanostructures can be prepared by employing chemical polymerization, electrochemical polymerization and photo‐induced polymerization. These CPs (such as polyaniline and polypyrrole) with special nanostructures possess high capacitance, superior rate capability ascribed to large electrochemical surface, and optimal ion diffusion path in the ordered nanostructures. The composites of nano‐structured conducting polymer and some conductive flexible substrates (such as carbon nanotube film and graphene film) are proved to be ideal electrode materials for high performance flexible SCs. Furthermore, high N‐containing CPs are very prospective for preparing N‐doped carbon materials used as flexible electrodes for flexible SCs. With respect to the extra pseudo‐capacitance induced by N atoms and superior stability derived from the conjugated graphitic structure of carbon materials, the obtained flexible SCs based on N‐doped carbon materials could achieve high capacitance, high rate performance, and superior cycling stability.
Molecular Recognition of Water‐soluble Pillar[n]arenes Towards Biomolecules and Drugs
Authors: Shu Xiaoyan , Xu Kaidi , Hou Dabin , Li Chunju 
Published: October 2018

AbstractThe exploration of molecular recognition of synthetic macrocycles in aqueous media is significantly important since most biological functions, activities and processes take place in water. Pillar[n]arenes (n=5–10) have been recognized as a new generation of macrocyclic arenes; much attention has been devoted to their host‐guest chemistry. This review summarizes the host‐guest properties of water‐soluble pillararenes towards biologically significant molecules and drugs. These water‐soluble pillararenes are classified into three major classes according to the electric charges of hydrophilic groups at their portals: anionic pillar[n]arenes (AP[n]s), cationic pillar[n]arenes (CP[n]s), and neutral pillar[n]arenes (NP[n]s). The host–guest affinities, binding modes, binding selectivity, stimuli‐responsiveness, as well as biomedical applications are comprehensively discussed.
Circuit breakers as market stability levers: A survey of research, praxis, and challenges
Authors: Sifat Imtiaz Mohammad , Mohamad Azhar 
Published: October 2018

AbstractCircuit breaker, an automated regulatory instrument employed to deter panic, temper volatility, and prevent crashes, is controversial in financial markets. Proponents claim it provides a propitious time out when price levels are stressed and persuades traders to make rational trading decisions. Opponents demur its potency, dubbing it a barrier to laissez‐faire price discovery process. Since conceptualization in 1970s and practice from 1980s, researchers focused mostly on its ability to allay panic, interference in trading, volatility transmission, prospect of self‐fulfilling prophecy through gravitational pull towards itself, and delayed dissemination of information. Though financial economists are forked on circuit breakers' usefulness, they are a clear favourite among regulators, who downplay the reliability of anti‐circuit breaker findings citing, inter alia, suspect methodology, and lack of statistical power. In the backdrop of 2007–2008 Crisis and 2010 Flash Crash, the drumbeats for more regulatory intervention in markets grew louder. Hence, it is unlikely that intervening mechanism such as circuit breakers will ebb. But are circuit breakers worth it? This paper synthesizes three decades of theoretical and empirical works, underlines the limitations, issues, and methodological shortcomings undermining findings, attempts to explain regulatory rationale, and provides direction for future research in an increasingly complex market climate.