bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic carcinoma metastasis to a lung carcinoma lesion and pulmonary fibrotic regions, overtaking the stromal microenvironment
Authors: Nakaya Takeo , Sogabe Masaya , Yamamoto Shin-ichi , Tsuji Kentaro , Nakaya Michio , Niki Toshiro , Endo Shunsuke , Tanaka Akira 
Published: June 2019

Abstract

Rationale:
Suppression and of cancer metastasis is one of the most important issues in cancer care. Considering the typical clinical course of metastases, cancer cells might prefer certain environments or conditions. However, favorable environments for cancer metastasis have not been clearly identified. We had previously described a case of dual, yet separate, pancreatic and colon cancer, in which the metastatic pancreatic cancer was localized at the invasive portion of the colon cancer. We hypothesized that metastatic pancreatic cancer took over the colon cancer microenvironment.

Patient concerns:
We experienced an another case of double cancer in a 65-year-old man who had lung squamous cell carcinoma and an independent pancreatic adenocarcinoma that metastasized to the liver as well as to the lung cancer lesion and pulmonary fibrotic regions associated with pneumothorax and bronchiolization.

Interventions:
The pneumothorax could not be controlled by conservative treatment. Thus, an emergency surgery with partial resection of the lower lobe of right lung was performed.

Diagnoses:
We found multiple pancreatic cancer metastases in the lung cancer and fibrotic lesions in the surgical specimen. However, we detected no metastasis in normal lung tissues except inside small arteries, although the lung cancer and fibrotic tissue areas were smaller than the normal lung tissue areas in the surgical specimen.

Outcomes:
The patient died 50 days after the surgery.

Lessons:
This case may thus provide evidence to strengthen our hypothesis that pancreatic cancer prefers to metastasize to other independent cancer lesions, overtaking the cancer microenvironment constructed by other independent cancers. The lung cancer microenvironment, rich in myofibroblasts and/or cancer-associated fibroblasts, might be suitable for pancreatic carcinoma metastasis. In addition, we propose the hypothesis that compared with normal tissues, noncancerous fibrotic lesions are preferable destinations for cancer metastasis. Furthermore, metastasis of pancreatic carcinoma to lung cancer and fibrotic tissues might be more common, although such cases have not been previously reported.
Prolonged lumbosacral pain as the initial presentation in acute lymphoblastic leukemia in an adult
Authors: Li Fanglin , Wang Jinxia , Liu Aifei , Xin Liuyan , Zhong Sisi , Hong Yang , Chen Yijian 
Published: June 2019

Abstract

Rationale:
The differential diagnosis of conditions manifesting as bone and joint pain is complex. Although many individuals with acute leukemia experience bone pain, lumbosacral pain as an early feature of acute lymphoblastic leukemia (ALL) is rare.

Patient concerns:
Here we report a case of an adult who presented with a 7-month history of persistent lumbosacral pain which had become more severe during the previous month.

Diagnoses:
Prior to referral, his full blood count revealed no abnormalities, and a computerized tomography scan revealed mild bone hyperplasia of his lumbar vertebrae, with disc herniations of L3–S1. His blood biochemistry and urinary test results had been normal. After referral to our clinic, tests of the morphology, immunology, cytogenetics, and molecular biology of his bone marrow led to a diagnosis of MLL-AF4 fusion positive B-cell ALL.

Interventions:
Prior to his referral, he had been treated with painkillers by local doctors. The painkillers initially provided pain relief, but their effect wore off over time. After diagnosis, he was started on an adult ALL chemotherapy protocol.

Outcomes:
His symptoms resolved within a week of starting chemotherapy. At his most recent assessment, 10 months after diagnosis, he was on maintenance chemotherapy and in remission.

Lessons:
This case illustrates that prolonged lumbosacral pain may be a symptom of a life-threatening condition, rather than only attributable to chronic inflammation or disk herniations. Therefore, clinicians need to pay attention to subtle differences in the clinical presentation of patients with lumbosacral pain.
Effect of comprehensive nursing intervention in preventing postoperative pain, complications, and psychological pressure in the otolaryngology department
Authors: Luan Rong-Lan , Zhu Ming-Xia , Sun Hai-Yan 
Published: June 2019

Abstract
This study aims to analyze the influence of comprehensive nursing intervention on the postoperative pain, complications, and psychological pressure of otolaryngology patients.
A total of 300 otolaryngology patients in our hospital from February 2016 to October 2017 were selected and randomly divided into 2 groups using the random number table: control group (n = 150), patients were given routine nursing; experimental group (n = 150), patients were given comprehensive nursing intervention. Postoperative pain, complications, and psychological pressure between the 2 groups were analyzed.
Residual pain in the experimental group at 3 months after the operation was lower than that in the control group (P < .05). The postoperative complications in the experimental group was lower than that in the control group (P < .05). The acute psychological pressure score and the psychological pressure self-test score in the experimental group were both lower than that in the control group (P < .05).
Comprehensive nursing intervention for otolaryngology patients was associated to relieving pain after the operation and psychological pressure of patients in the short and long term. Besides, comprehensive nursing intervention for otolaryngology patients was associated with a lower risk of complications.
Effectiveness of Chinese herbal medicine for patients with primary insomnia
Authors: Zhang Hongshi , Liu Peng , Wu Xingquan , Zhang Yan , Cong Deyu 
Published: June 2019

Abstract

Background:
Traditional medicine is widely used for patients with primary insomnia, but the studies showed inconsistent results. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of Chinese herbal medicine (CHM) versus placebo for primary insomnia patients.

Methods:
The electronic databases including PubMed, EmBase, Cochrane library, and China National Knowledge Infrastructure were searched to identify the RCTs published from inception till July 2018. The summary weighted mean difference (WMD) with its 95% confidence interval (CI) for Pittsburgh sleep quality index (PSQI), sleep onset latency, total sleep duration, Athens insomnia scale (AIS), and sleep efficiency were calculated using random-effects model.

Results:
Fifteen RCTs comprising 1500 patients were finally included in the meta-analysis. Overall, patients who received CHM had lower levels of PSQI (WMD: −2.36; 95% CI: −4.02 to −0.70; P = .005), sleep onset latency (WMD: −11.54; 95% CI: −20.55 to −2.54; P = .012), and AIS (WMD: −0.59; 95% CI: −0.97 to −0.22; P = .002) as compared with placebo. Moreover, the summary WMDs of CHM versus placebo were associated with higher total sleep duration (WMD: 0.79; 95% CI: 0.56–1.02; P < .001), and sleep efficiency (WMD: 9.72; 95% CI: 6.49–12.96; P < .001). The treatment effect on PSQI might be affected by publication year, sample size, mean age, percentage male, diagnostic tool, duration of insomnia, treatment duration, and study quality.

Conclusion:
The findings of this meta-analysis indicated that CHM could significantly improve the symptoms of insomnia than placebo for patients with primary insomnia.
Sporadic Creutzfeldt–Jakob disease presenting as dizziness and cognitive decline
Authors: Xu Yuhao , Xu Jianhui , Zhang Jian , Cai Zhirong , Wei Hong , Yu Ming , Li Yuefeng 
Published: June 2019

Abstract

Rationale:
Creutzfeldt–Jakob disease (CJD) is an infrequent and rapidly fatal neurodegenerative disease without effective cure. Common presentations of CJD include rapidly progressive cognitive decline, behavioral changes, cerebellar dysfunction, and visual disturbances. Since clinicians may see only very few cases during their professional career, it is important to be familiar with the clinical presentation and progression, and allow for quick diagnosis.

Patient concerns:
We reported an elderly woman had recurrent attacks of dizziness in the preceding month. She began to suffer progression of memory disturbance half a month before admission and was admitted to our department in a coma.

Diagnosis:
The accessory examinations of magnetic resonance imaging (MRI), electroencephalography (EEG), 14-3-3 protein in cerebrospinal fluid and S100 protein in serum support the diagnosis of sporadic CJD (sCJD). Combined with this evidence and clinical symptom, we made a clinical diagnosis of sCJD.

Interventions:
Supportive treatment.

Outcomes:
After 2 months of active treatment, the patient's condition had not improved, and the patient died 82 days after admission.

Lessons:
Clinicians should attach importance to sCJD, which is significant for the prevention of transmission and treatment.
Effectiveness of rehabilitation training combined with acupuncture on aphasia after cerebral hemorrhage
Authors: Dong Xin-shu , Song Guang-fu , Wu Cheng-ji , Zou Chun-yin , Sun Guang-tao , Huang Zuo-yi 
Published: June 2019

Abstract

Background:
This study aims to systematically evaluate the effectiveness of rehabilitation training (RT) combined with acupuncture on aphasia after cerebral hemorrhage (CH).

Methods:
PUBMED, Cochrane Central Register of Controlled Trials, EMBASE, Web of Science, Ovid, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure will be searched to identify any potential studies from inception to March 1, 2019, without language restrictions. All randomized controlled trials and case-controlled studies assessing the effectiveness of RT combined with acupuncture for the treatment of aphasia following CH will be included in this study. Cochrane risk of bias tool will be used to determine the methodological quality for included studies. RevMan 5.3 software (Cochrane Community, London, UK) will be utilized to perform statistical analysis.

Results:
This study will systematically evaluate the effectiveness of RT and acupuncture for aphasia post CH. Primary outcome includes aphasia, which can be measured by Aachener Aphasia Test or Communicative Activity Log or other related scales. Secondary outcomes consist of speech performance, as assessed by Western Aphasia Battery-Revised; measure of skill in Supported Conversation scales; measure of Participation in Conversation scales; types of strategies used in conversation; occurrence and repair of conversation breakdowns; as well as any adverse events.

Conclusion:
The results of this study will provide present evidence on assessing effectiveness of RT and acupuncture after CH.

Dissemination and ethics:
The findings of this study are expected to be published in peer-reviewed journals. It does not require ethical approval, because no individual data will be utilized in this study.

Systematic review registration:
PROSPERO CRD42019131587.
Conservative treatment for stable low-energy thoracolumbar vertebral fractures in nonfused segments among elderly patients with diffuse idiopathic skeletal hyperostosis
Authors: Okano Ichiro , Tachibana Tetsuya , Nishi Masanori , Midorikawa Yuki , Hoshino Yushi , Sawada Takatoshi , Kudo Yoshifumi , Toyone Tomoaki , Inagaki Katsunori 
Published: June 2019

Abstract
Diffuse idiopathic skeletal hyperostosis (DISH) is the spontaneous osseous fusion of the spine with anterior bridging osteophytes. It is well-known that conservative treatment for vertebral fractures of fused segment among DISH spines is associated with worse clinical outcomes. However, the prognosis of conservatively treated stable vertebral fractures in neighboring nonfused segments among DISH spines is still unknown. The purpose of this study was to analyze the results of conservative treatment of stable low-energy thoracolumbar (TL) vertebral fracture in nonfused segments among patients with DISH lesions.
A total of 390 consecutive patients who visited an emergency department by ambulance with spinal trauma between 2013 and 2017 were retrospectively reviewed. The diagnosis of DISH was determined based on fused spinal segments with bridging osteophytes in at least 3 adjacent vertebrae. For each case of stable TL vertebral fractures in nonfused segments of the DISH spine, we identified 2 age-, sex-, and fracture lesion-matched non-DISH controls who underwent conservative treatment for low-energy TL vertebral fractures during the same period.
Of the 33 identified cases of TL fractures with DISH, 14 met our inclusion criteria. The bony union rates of the DISH group and control group were 57% and 75% at the 3-month follow-up examination (P = .38) and 69% and 100% at the 6-month follow-up examination (P = .02), respectively. Among the 13 patients with fractures below the TL junction, fused segments were not diagnosable based on the initial standard radiographs of the lumbar spine for 61.5% of patients.
Although this study design was exploratory and the sample size was small, our results suggest that with conservative treatment, stable fractures in nonfused segments in the DISH spine might have a worse prognosis than ordinary osteoporotic vertebral fractures. The diagnosis of coexisting DISH lesions can be missed when only radiographs of the lumbar spine are used to determine the diagnosis.
Pre-diagnostic beta-blocker use and head- and neck cancer risk
Authors: Kim Min-Su , Han Kyung Do , Kwon Soon Young 
Published: June 2019

Abstract
β-blockers have been reported to exhibit potential anticancer effects in various cancer studies. However, few clinical studies concerning head and neck cancer have been conducted. We hypothesized that β-blockers could decrease the incidence of head and neck cancer. Therefore, we investigated the association between β-blocker treatment and head and neck cancer incidence.
Between January 2006 and December 2015, we selected 12,127 patients with head and neck cancer for this nationwide study using data from the Korean Health Insurance Review and Assessment Service. The patients were matched 1:5 with 60,635 control participants according to age, sex, and, region. Logistic regression analysis was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of cancer associated with β-blocker treatment. In the analysis, a crude (simple), adjusted model (adjusted model for age, sex, income, region of residence, hypertension, diabetes, and hyperlipidemia) was used.
The OR for head and neck cancer incidence was not lower in the β-blocker cohort (OR: 1.18; 95% CI: 1.105–1.26), especially for the oral cavity (OR: 1.165; 95% CI: 1.013–1.340), hypopharynx (OR: 1.555; 95% CI: 1.232–1.963), nasopharynx (OR: 1.251; 95% CI: 1–1.564), and paranasal sinus (OR: 1.378; 95% CI: 1.027–1.849). The duration of β-blocker use was not related to head and neck cancer incidence.
This study did not provide evidence that β-blockers can decrease the risk of head and neck cancer.
Evaluation of blood flow on optic nerve head after pattern scan and conventional laser panretinal photocoagulation
Authors: Iwase Takeshi , Mikoshiba Yuji , Ra Eimei , Yamamoto Kentaro , Ueno Yoshitaka , Terasaki Hiroko 
Published: June 2019

Abstract
To evaluate the changes in the blood flow on retina and the optic nerve head (ONH) after conventional laser treatment and to compare it to that after patterned scanning laser (PASCAL) treatment in patients with severe nonproliferative diabetic retinopathy (S-NPDR).
In this prospective, cross-sectional study, the blood flow on retina and the ONH was assessed by laser speckle flowgraphy using the mean blur rate (MBR) in 39 eyes with S-NPDR before, 1, 4, 8, 12 weeks after panretinal photocoagulation (PRP). Of 39 eyes, 17eyes with 17 patients treated by conventional laser and 22 eyes with 22 patients treated by PASCAL.
The mean age was 55.5 ± 11.5 years in the conventional laser group, 55.6 ± 11.8 years in the PASCAL group. The MBR-vessel, which can be dominantly expressed as retinal blood flow, was significantly reduced after PRP treated by conventional laser (P < .001), but did not change after PRP treated by PASCAL. The ratio of MBR-vessel to the baseline was significantly lower in the conventional laser group only at Week 1 (P = .045). The MBR-tissue, which can be dominantly expressed as the ONH blood flow, did not significantly change after PRP in the both group. The multiple stepwise regression analysis revealed that the laser burns was an independent factor significantly correlated with the ratio of MBR-vessel at Week 1 to the baseline (β = −0.550, P = .012).
The retinal blood flow was significantly reduced during the 12 weeks only after completion of PRP by conventional laser treatment. Our results indicate that short pulse on PRP treatment performed by the PASCAL would not significantly reduce the retinal blood flow.
Is it safe to perform gastrectomy in gastric cancer patients aged 80 or older?
Authors: Xu Yixin , Wang Yibo , Xi Cheng , Ye Nianyuan , Xu Xuezhong 
Published: June 2019

Abstract

Background:
Few studies have focused on octogenarian patients with gastric cancer (GC) who have undergone gastrectomy. This meta-analysis of published studies was performed to assess the safety of treating octogenarian GC patients with surgery.

Methods:
Databases, including PubMed, Embase, Web of Science, and Cochrane Library were searched until January 2019. The incidence of preoperative comorbidities, postoperative complications, and mortality was assessed using odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Further, the hazard ratios (HRs) with 95% CIs were applied for survival outcomes.

Results:
A total of 18,179 patients with GC in 21 studies were included. Our results demonstrated that octogenarian patients were associated with a higher burden of comorbidities (OR = 2.79; 95% CI: 2.37, 3.28; P = .00), high incidences of overall postoperative complications (OR = 1.48; 95% CI: 1.22, 1.81; P = .00), medical postoperative complications (OR = 2.58; 95% CI: 1.91, 3.49; P = .00), in-hospital mortality (OR = 3.24; 95% CI: 2.43, 4.31; P = .00) and poor overall survival (HR = 1.96; 95% CI: 1.65, 2.27; P = .00).

Conclusions:
Considering the high burden of comorbidities, high incidences of postoperative complications and mortality, surgery for extremely elderly patients with GC requires deliberation. Individualized treatment is recommended for such patients.
Catatonia in Adolescence: First Onset Psychosis or Anti-NMDAr Encephalitis?
Authors: Averna Roberto , Battaglia Claudia , Labonia Milena , Riccioni Assia , Vicari Stefano 
Published: June 2019

Abstract
Catatonia is a rare condition that can occur in developmental disorders, but it is more frequently seen in schizophrenia. Recently, a high prevalence of cerebrospinal fluid abnormalities including the detection of antineuronal autoantibodies has been observed in psychotic patients. Among these autoimmune encephalopathies associated with a psychiatric condition, a great deal of attention has been paid to anti–N-methyl-d-aspartate receptor (NMDAr) encephalitis, which may present, among other things, symptoms such as catatonia, which therefore imposes a differential diagnosis with respect to the early psychosis. The aim of our study was to describe the clinical characteristics of 4 cases with catatonic symptoms to understand the differences between the psychotic symptoms due to a type of encephalitis anti-NMDAr and the psychotic symptoms without anti-NMDAr.
Treatment of Sleep Bruxism With a Single Daily Dose of Buspirone in a 7-Year-Old Boy
Authors: Sağlam Ebru , Akça Ömer Faruk 
Published: June 2019

Abstract
Sleep bruxism is a temporomandibular joint dysfunction that could conclude in various problems including masseter muscle hypertrophy, headaches, and periodontal problems. Despite various treatment strategies, such as behavioral therapy, oral appliances, and pharmacotherapy, suggested, there is no specific treatment for this disorder. We present a 7-year-old boy whose sleep bruxism symptoms disappeared with a single daily dose of buspirone treatment in this report.
Single Cell Viewer (SCV): An interactive visualization data portal for single cell RNA sequence data
Authors: Wang Shuoguo , Brett Constance , Bolisetty Mohan , Golhar Ryan , Neuhaus Isaac , Ravi Kandasamy 
Published: June 2019

AbstractMotivationThanks to technological advances made in the last few years, we are now able to study transcriptomes from thousands of single cells. These have been applied widely to study various aspects of Biology. Nevertheless, comprehending and inferring meaningful biological insights from these large datasets is still a challenge. Although tools are being developed to deal with the data complexity and data volume, we do not have yet an effective visualizations and comparative analysis tools to realize the full value of these datasets.ResultsIn order to address this gap, we implemented a single cell data visualization portal called Single Cell Viewer (SCV). SCV is an R shiny application that offers users rich visualization and exploratory data analysis options for single cell datasets.AvailabilitySource code for the application is available online at GitHub (http://www.github.com/neuhausi/single-cell-viewer) and there is a hosted exploration application using the same example dataset as this publication at http://periscopeapps.org/scv_tirosh.Contactisaac.neuhaus@bms.com; kandasamy.ravi@bms.com
Dependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform
Authors: Sung Yongjin , Tetrault Marc-Andre , Takahashi Kazue , Ouyang Jinsong , Pratx Guillem , Normandin Marc , Fakhri Georges El 
Published: June 2019

AbstractHigh glucose uptake by cancer compared to normal tissues has long been utilized in fluorodeoxyglucose-based positron emission tomography (FDG-PET) as a contrast mechanism. The FDG uptake rate has been further related to the proliferative potential of cancer, specifically the proliferation index (PI) − the proportion of cells in S, G2 or M phases. The underlying hypothesis was that the cells preparing for cell division would consume more energy and metabolites as building blocks for biosynthesis. Despite the wide clinical use, mixed reports exist in the literature on the relationship between FDG uptake and PI. This may be due to the large variation in cancer types or methods adopted for the measurements. Of note, the existing methods can only measure the average properties of a tumor mass or cell population with highly-heterogeneous constituents. In this study, we have built a multi-modal live-cell radiography system and measured the [18F]FDG uptake by single HeLa cells together with their dry mass and cell cycle phase. The results show that HeLa cells take up twice more [18F]FDG in S, G2 or M phases than in G1 phase, which confirms the association between FDG uptake and PI at a single-cell level. Importantly, we show that [18F]FDG uptake and cell dry mass have a positive correlation in HeLa cells, which suggests that high [18F]FDG uptake in S, G2 or M phases can be largely attributed to increased dry mass, rather than the activities preparing for cell division. This interpretation is consistent with recent observations that the energy required for the preparation of cell division is much smaller than that for maintaining house-keeping proteins.