bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective pilot evaluation of vaginal and urine self-sampling for the Roche cobas 4800 HPV test for cervical cancer screening
Authors: Hwang Sang-Hyun , Shin Hye Young , Lee Dong Ock , Sung Na Young , Lee Bomyee , Lee Do-Hoon , Jun Jae Kwan 
Published: June 2018

AbstractThis pilot study sought to evaluate the feasibility of utilizing vaginal self-swabs and urine samples for HPV-based cervical cancer screening in 700 women who had undergone conventional Pap smear screening via the national cervical cancer program in Korea. The cobas 4800 HPV test was utilized to detect HPV in the self-samples. Pap smear results revealed three cases of atypical squamous cells of undetermined significance, 649 cases of negative for an intraepithelial lesion or malignancy, and 48 non-specific inflammatory findings. High-risk HPV was detected in 6.7% of urine samples and 9.6% of vaginal self-swab samples. The overall agreement for HPV 16/18 between urine and vaginal self-swab samples was 99.1% (95%CI 98.1% to 99.6%). Colposcopic biopsy revealed one cervical intraepithelial neoplasia (CIN) 3 lesion, 12 CIN1 lesions, and 23 normal or chronic cervicitis lesions. In conclusion, urine and vaginal self-swab sampling was feasible and deemed a potential alternative for HPV detection in women who hesitate to participate in cervical cancer screening programs. Meanwhile, due to overall lower rates of abnormal cytology and sexual risk behaviors in Korea, a larger sample size than expected is needed to assess the sensitivity of CIN2+ detection via self-samples.
Energy transfer and correlations in cavity-embedded donor-acceptor configurations
Authors: Reitz Michael , Mineo Francesca , Genes Claudiu 
Published: June 2018

AbstractThe rate of energy transfer in donor-acceptor systems can be manipulated via the common interaction with the confined electromagnetic modes of a micro-cavity. We analyze the competition between the near-field short range dipole-dipole energy exchange processes and the cavity mediated long-range interactions in a simplified model consisting of effective two-level quantum emitters that could be relevant for molecules in experiments under cryogenic conditions. We find that free-space collective incoherent interactions, typically associated with sub- and superradiance, can modify the traditional resonant energy transfer scaling with distance. The same holds true for cavity-mediated collective incoherent interactions in a weak-coupling but strong-cooperativity regime. In the strong coupling regime, we elucidate the effect of pumping into cavity polaritons and analytically identify an optimal energy flow regime characterized by equal donor/acceptor Hopfield coefficients in the middle polariton. Finally we quantify the build-up of quantum correlations in the donor-acceptor system via the two-qubit concurrence as a measure of entanglement.
Phytochemicals-mediated production of hydrogen peroxide is crucial for high antibacterial activity of honeydew honey
Authors: Bucekova Marcela , Buriova Monika , Pekarik Ladislav , Majtan Viktor , Majtan Juraj 
Published: June 2018

AbstractHoneydew honey is increasingly valued due to its pronounced antibacterial potential; however, the underlying mechanism and compounds responsible for the strong antibacterial activity of honeydew honey are still unknown. The aim of this study was to investigate the inhibition of bacterial growth of 23 honeydew honey samples. Activity of bee-derived glucose oxidase (GOX) enzyme, the content of defensin-1 (Def-1) and hydrogen peroxide (H2O2), and total polyphenol content were determined in the 23 honey samples. Our results demonstrated that antibacterial activity of honeydew honey was equivalent to medical-grade manuka and kanuka honey and was abolished by catalase. Although H2O2 is an important factor in the inhibition of bacterial growth, polyphenolic compounds and their interaction with H2O2 are the key factors responsible for high antibacterial activity of honeydew honey. In addition, our results indicated that the antibacterial activity of honeydew honey is not dependent on GOX-mediated production of H2O2 or the presence of Def-1.
Imaging EGFR and HER3 through 89Zr-labeled MEHD7945A (Duligotuzumab)
Authors: McKnight Brooke N. , Kuda-Wedagedara Akhila N. W. , Sevak Kuntal K. , Abdel-Atti Dalya , Wiesend Wendy N. , Ku Anson , Selvakumar Dakshnamurthy , Carlin Sean D. , Lewis Jason S. , Viola-Villegas Nerissa T. 
Published: June 2018

AbstractTumor resistance to treatment paved the way toward the development of single agent drugs that target multiple molecular signatures amplified within the malignancy. The discovered crosstalk between EGFR and HER3 as well as the role of HER3 in mediating EGFR resistance made these two receptor tyrosine kinases attractive targets. MEHD7945A or duligotuzumab is a single immunotherapy agent that dually targets both molecular signatures. In this study, a positron emission tomography (PET) companion diagnostic to MEHD7945A is reported and evaluated in pancreatic cancer. Tumor accretion and whole body pharmacokinetics of 89Zr-MEHD7945A were established. Specificity of the probe for EGFR and/or HER3 was further examined.
Observation of a non-equilibrium steady state of cold atoms in a moving optical lattice
Authors: Chong Kyeong Ock , Kim Jung-Ryul , Kim Jinuk , Yoon Seokchan , Kang Sungsam , An Kyungwon 
Published: June 2018

AbstractNon-equilibrium dynamics expands our understanding on physical processes based on the conventional equilibrium physics. In particular, non-equilibrium steady states with continuous flow among them have drawn much interest related to various biochemical processes, biomolecular motors, and high-temperature quantum entanglement as well as Bose–Einstein condensates. Here we report observation of a non-equilibrium steady states of atoms achieved in a hybrid of a moving optical lattice and a surrounding cold atom cloud in a phase-stabilized magneto-optical trap. A part of atoms are localized and transported in the moving optical lattice and the rest are not localized in the lattice while trapped as a cold cloud of atoms. These motional states coexist with continuous transition between them. Our model calculations well reproduce the key features of the experimental observations including stepwise transitions, confirming the existence of a non-equilibrium steady state with characteristics of asymmetric simple exclusion process in the cold atom system.
Millimeter wave spectra of ethyl isocyanate and searches for it in Orion KL and Sagittarius B2
Authors: Kolesniková L. , Alonso E. R. , Tercero B. , Cernicharo J. , Alonso J. L. 
Published: June 2018

Context. Relatively high abundances of methyl isocyanate (CH3NCO), a methyl derivative of isocyanic acid (HNCO), found in the Orion KL and Sgr B2 molecular clouds suggest that its ethyl derivative, ethyl isocyanate (CH3CH2NCO), may also be present.
Aims. The aim of this work is to provide accurate experimental frequencies of ethyl isocyanate in its ground and excited vibrational states in the millimeter wave region to support searches for it in the interstellar medium.
Methods. The rotational spectrum of ethyl isocyanate was recorded at room temperature from 80 to 340 GHz using the millimeter wave spectrometer in Valladolid. Assigned rotational transitions were analyzed using the S -reduced semirigid-rotor Hamiltonian.
Results. More than 1100 distinct frequency lines were analyzed for the ground vibrational state of the cis conformer as well as for three vibrational satellites corresponding to successive excitation of the lowest-frequency C–N torsional mode. Newly determined rotational and centrifugal distortion constants were used for searches of spectral features of ethyl isocyanate in Orion KL and Sgr B2 clouds. Upper limits to CH3CH2NCO in these high-mass star-forming regions were obtained.
Eltern möchten dabei sein!
Authors: Baumeister Heike , Kremp Annette , Schiff Andrea 
Published: June 2018

ZusammenfassungDie Möglichkeit der Anwesenheit von Eltern während der Reanimation ihres Kindes wird zunehmend diskutiert – in der Praxis aber nur selten gewährt. Die
Erfahrungen und Meinungen der Pflegenden und der betroffenen Eltern zu diesem Thema wurden bisher im deutschsprachigen Raum nur unzureichend erforscht. In ihren
qualitativen Forschungsarbeiten führte Heike Baumeister sieben Experteninterviews mit Pflegenden und Annette Kremp drei Interviews mit betroffenen Müttern
durch. Die Ergebnisse weisen einige Überschneidungen auf. Nicht nur der elterliche Wunsch nach Anwesenheit und das Verständnis der Pflegenden für diesen Wunsch,
sondern auch die Bedeutung einer professionellen Begleitung der Eltern gehen beispielsweise aus beiden Studien hervor. Anschlussstudien mit ähnlichen
Fragestellungen sind dringend notwendig.
Als Nurse Practitioner zurück nach Deutschland
Authors: Holman Samia , Kocks Andreas 
Published: June 2018

ZusammenfassungPraktisch mit Pflegestudium in der direkten Patientenversorgung zu arbeiten gehört in vielen Ländern zum Standard. Samia Holman ging nach ihrer Schulausbildung
in die USA und qualifizierte sich dort in der Pflege. Nach zwei absolvierten Studiengängen führte ihre Arbeit sie in eine niedergelassene Arztpraxis – als Nurse
Practitioner im Sinne des Advanced Nursing Practice (ANP). Ein anspruchsvolles Arbeitsfeld mit viel Autonomie und Verantwortung. Jetzt, vor dem Weg zurück nach
Deutschland, reflektiert Samia Holman ihre Tätigkeit in den USA und fragt sich, wie sie mit ihrer Qualifikation in Deutschland arbeiten kann.
Etude des antigènes plaquettaires et, en particulier, du fibrinogène
Authors: Salmon J , Bounameaux Y 
Published: June 2018

Résumé1) Le fibrinogène est le principal antigène décelable par la précipitation en gélose et par l’immuno-électrophorèse dans les plaquettes de l’homme, du boeuf, du mouton, du cheval et du porc.2) Il est essentiellement situé à l’intérieur des plaquettes ou masqué à leur périphérie. Il en existe également dans l’atmosphère plasmatique périplaquettaire.3) Les plaquettes bovines contiennent une autre substance antigénique, dénaturée par la thrombine et dont la mobilité électrophorétique est celle d’une α-globuline. Elles renferment un 3me antigène dont la nature doit encore être précisée.4. La signification de ces faits est brièvement discutée.
Über den Einfluß von 5-Hydroxytryptamin (Serotonin), 5-Hydroxytryptophan und von Serotoninantagonisten auf die Retraktion von Blutgerinnseln
Authors: Gross Rudolf , Staufenberg Erika 
Published: June 2018

ZusammenfassungSerotonin-Kreatininsulfat hatte in Konzentrationen von 0,05 bis 1,0 mg/ccm bei Temperaturen von 20° und 37° C keinen retraktionsauslösenden oder retraktionsfördernden Einfluß auf die Gerinnsel aus thrombozytenarmen menschlichen Plasmen (< 100/cmm bis 50 000/cmm). Negative Ergebnisse zeitigten auch Zusätze von 5-dl-Hydroxytryptophan (0,6 bis 2,0 mg/ccm).Mit Brom-Lysergsäurediäthylamid (0,05 und 0,1 mg/ccm) wurde die Retraktion von Gerinnseln aus thrombozytenreichem Plasma nicht gehemmt. Dagegen führten die Serotoninantagonisten l-Benzyl-2,5-Dimethylserotonin und 1-Benzyl-2,5-Dimethylbufotenin zu einer Retraktionshemmung in Gerinnseln aus plätt-chenreichem Plasma. Für den letzteren (stärkeren) Serotoninantagonisten war eine Störung der Retraktion noch mit 0,01 mg/ccm nachweisbar. Die Retrak-tionsstörungen wurden durch gleichzeitigen Serotoninzusatz nicht aufgehoben.Die Aufnahme des Venenblutes in Natriumzitrat mit Zusatz von Mescalin, einem Hemmstoff der (serotoninspaltenden) Monoaminooxydase, hatte weder auf die spontane Retraktion von Gerinnseln aus thrombozytenarmem Plasma noch nach Zugabe von Serotonin oder 5-Hydroxytryptophan einen retraktions-steigernden Einfluß. Hinsichtlich der Retraktion voll wirksame Dosen von l-Benzyl-2,5-Dimethylbufotonin führten bei Inkubation bis zu 45 Minuten zu keiner oder zu nur geringfügigen Störungen der Thrombozytenzahl, der Thrombozytenmorphologie und der Thrombozytenfaktor-3-Aktivität.Die Spezifität der geschilderten Hemmwirkung der Serotoninantagonisten über das Plättchenserotonin oder verwandte Substanzen sowie die Bindung des Serotonins in den Thrombozyten werden diskutiert.
The Hemorrhagic Synchorne Complicating Extracorporeal Shunting of Blood: An Experimental Study of its Pathogenesis
Authors: Penick George D. , Averette Hervy E. , Peters Richard M. , Brinkhous Kenneth M. 
Published: June 2018

SummaryDogs subjected to extracorporeal circulation with a modified D e Wall heart-lung apparatus developed thrombocytopenia and severe deficiency of the antihemophilic factor (AHF). To quantitate this reaction more accurately, a two-stage method of study was devised whereby citrated blood in the first stage was subjected to artificial, oxygenation and then in the second stage, was transfused into recipient dogs. In all cases, depression in AHF and platelets occurred even though fibrinogen remained at high levels. Depression in AHF levels could also be produced by mechanical damage to tissues of the extremities or by the autotransfusion of stored blood. Control transfusion of fresh blood produced no such effects.
The Effect of Fibrinogen Concentration on Susceptibility of Clots to in vitro Clot Lysis with Plasmin
Authors: Freiman A. H , Cliffton E. E 
Published: June 2018

SummaryThe effect of fibrinogen(fibrin) concentration on the degree of clot lysis has been is shown. These experiments demonstrate: (1) A direct correlation between degree of clot lysis and liberation of radioactive breakdown products, (2) that increasing concentrations of fibrinogen result in decreasing lysis of the clot by a standard fibrinolysin solution, (3) that lysis occurs more rapidly at pH 7.4 than at pH 7.6 and 7.8, (4) that increase in surface area results in increased lysis and (5) that increasing concentration of plasmin results in increased lysis of the clot.
A New Approach to the Thrombocytopathies. Thrombocytopathy A
Authors: Johnson Shirley A. , Monto Raymond W. , Caldwell M. June 
Published: June 2018

SummaryA group of patients with clinical hemorrhagic disease who exhibited a prolonged bleeding time and a short prothrombin consumption time classified as Thrombocytopathy A were studied utilizing procedures involving isolated platelets and purified prothrombin. These frozen and thawed platelet extracts had poor platelet factor 3 activity which was normal after the extracts had been treated with ultrasonic oscillations. The electron microscope studies of the morphology of these platelets were abnormal. It is concluded that these platelets contain adequate amounts of platelet factor 3 but are resistant to disintegration and the activity is only liberated with difficulty.The authors wish to thank Miss Jeanne M. Riddle, M.S. medical technologist in Hematology at Henry Ford Hospital for technical assistance in providing the platelet counts for this investigation.
Hallermann–Streiff Syndrome: Magnetic Resonance Imaging of a Rare Disorder
Authors: Sabat Shyam , Slonimsky Einat 
Published: June 2018

AbstractHallermann–Streiff syndrome (HSS) is a rare disorder characterized by dyscephalia, facial, and dental abnormalities. We report the brain magnetic resonance imaging features of a 26-year-old male patient who has a past medical history significant for spastic paraplegia, vision problems, and epilepsy.
Comparing Older Persons’ Human Rights: Exploratory Study of the International Older Persons’ Human Rights Index (IOPHRI)
Authors: Doron Israel , Cox Carole , Spanier Benny 
Published: June 2018

Abstract

Background and Objectives
Over the last 2 decades, several international indices have been developed to describe the status of older persons. None, however, have examined their human rights. The International Older Persons’ Human Rights Index (IOPHRI) fills in this gap by analyzing the formal legislative foundation of human rights for older people. The objective of this exploratory study is to examine the IOPHRI while comparing the legislation in 6 countries.

Research Design and Methods
A comparative international exploratory study comparing the human rights legislation of 6 countries: United States, Chile, Ireland, South Africa, India, and Australia in 5 different human rights domains: constitutional, protection, familial and informal support, planning, and empowerment.

Results
The findings suggest that the actual relationship between formal human rights of older persons and the real world is complex: for example, while the IOPHRI index places South Africa in first place, it is far behind compared with all other participants in the Global AgeWatch Index (which measures objective elements such as life expectancy at 60, or poverty rates in old age).

Discussion and Implications
Measuring and indexing human rights of older persons reveal significant methodological issues. Beyond these methodological challenges, comparing the ranking of the IOPHRI to nonlegalistic indices raises significant questions about the relationship between formal human rights and the actual living experiences of older persons.
Who is fishing on what stock: population-of-origin of individual cod (Gadus morhua) in commercial and recreational fisheries
Authors: Jorde Per Erik , Kleiven Alf Ring , Sodeland Marte , Olsen Esben Moland , Ferter Keno , Jentoft Sissel , Knutsen Halvor 
Published: June 2018

AbstractAtlantic cod (Gadus morhua) in Skagerrak are structured into distinct ecotypes or stock components that have been severely depleted over the past decades. To improve our understanding of how local commercial and recreational fisheries influence cod stocks, we investigated whether these user groups target different stock components of cod. Cod were sampled from the recreational rod and line fishery and from commercial shrimp trawlers catching cod as by-catch. Based on a large set of single nucleotide polymorphisms (SNPs), we defined a subset of 27 semi-diagnostic SNPs designed to discriminate between two cod stock components: “inner fjord” cod and “North Sea” cod, designated by their dominant habitat preferences. Genetic assignments of fishery-caught cod indicated that 4% of individuals caught by shrimp trawlers belonged to the inner fjord cod component and 96% to the North Sea, whereas among cod caught by recreational fishers, the estimated percentages were 11.8 and 88.2%, respectively. Our findings confirm the existence of two sympatric cod stock components in coastal Skagerrak, indicating that existing management units are biologically inappropriate and should be reconsidered. Furthermore, more attention should be given to recreational angling to reduce fishing mortality on the depleted inner fjord cod component.
TRPC Channels—Insight from the Drosophila Light Sensitive Channels
Authors: Katz Ben , Pak William L. , Minke Baruch 
Published: June 2018

Abstract
The Drosophila Transient Receptor Potential (TRP) channel is the founding member of a large and diverse family of channel proteins. These channels are evolutionarily conserved from yeast to mammals and are found in many organisms and tissues. The TRP family is classified into seven subfamilies, while the most closely related to the Drosophila TRP are members of the TRPC (Canonical) subfamily. This review focuses on a comparison between properties of Drosophila TRP, discovered in the native photoreceptor cells, and that of mammalian TRPC channels. These properties include: (i) organization of TRP channels in multimolecular signaling complexes via PDZ-containing scaffold proteins, (ii) mutations causing constitutive activity of TRP channels and cell degeneration, (iii) regulation of TRP channels by phosphorylation, and (iv) hypoxia/anoxia-activation of TRP channels. Hence, we suggest that knowledge gained from studies of Drosophila may guide studies in mammals that attempt elucidating diverse types of diseases caused by TRPC channel malfunction.
Leibniz’s Network
Authors: Hotson Howard 
Published: June 2018

Leibniz’s network is a major subject of study in its own right, exemplifying the centrality of the ‘republic of letters’ to the intellectual history of early modern Europe. Yet the primary reason for discussing it here is that understanding Leibniz’s network is also indispensable for understanding his thought. Leibniz’s thought is not a fixed product, immortalized in a small number of polished publications. Its content and expression evolved constantly in a long series of fragmentary statements, many penned in dialogue with contemporaries. To understand these fragments, we must understand the hundreds of people with whom Leibniz was interacting, and the networks and communities for which they spoke. Grasping the complexity of these interactions surpasses the limitations of print technology. Obtaining a synoptic understanding of Leibniz’s network therefore requires a new generation of digital infrastructure capable of assembling and exploring the relevant data in a highly collaborative and interactive fashion.
History of Disorders of Writing and Reading
Authors: Henderson Victor W. 
Published: June 2018

Abstract
In the history of medicine, studies of agraphia and alexia have figured prominently in efforts to understand neural underpinnings of cognition. The central historical figure is Jules Dejerine (1849–1917), whose worked followed pioneering studies on aphasia by Broca and Wernicke. Dejerine identified the left angular gyrus as crucial for reading and writing, and he described syndromes commonly referred to as alexia with agraphia and alexia without agraphia (pure alexia). Models derived from Broca, Wernicke, and Dejerine are based on concepts of specialized cortical centers linked by subcortical nerve fiber pathways. Following his death, Dejerine’s clinical–anatomical formulations were deconstructed by Marie, Head, and Goldstein, only to be resurrected in the second half of the 20th century. Newer varieties of agraphia or alexia were linked to apraxia, impaired body image, spatial misperception, and interhemispheric disconnection; and newer syndromes were identified from information processing approaches focused on error analyses.
Scientifically Supported Writing Practices
Authors: Graham Steve , Rouse Amy Gillespie , Harris Karen R. 
Published: June 2018

Abstract
This article examines scientifically supported writing practices (SSWPs) and what instructional research tells us about the teaching of writing to school-aged students. It first explains why teachers should apply SSWPs before considering writing practices based on the insights and experience of professional writers and teachers, along with their limitations. It then describes writing practices based on scientific evidence and outlines three reasons why SSWPs are important to writing instruction and should become central to everyday writing practices. Twenty SSWPs that provide teachers with a variety of tools for improving students’ writing are analyzed; these SSWPs also provide a framework for a writing program that addresses six principles. The article concludes with a discussion of two basic theories that have dominated much of the discussion about how writing develops: The first takes into account how context shapes writing development, and the second emphasizes the role of cognition and motivation.
The Dynamics of Constitutional Conventions in Westminster Democracies
Authors: Barry Nicholas , Miragliotta Narelle , Nwokora Zim 
Published: June 2018

AbstractConstitutional conventions are fundamental to the operation of Westminster democracies. However, despite their political significance, there have been few attempts to analyse and theorise their internal dynamics. This article aims to address this gap by identifying the triggers of constitutional ‘softening’, when the opportunity for convention change emerges; and examining how such moments interact with the particular properties of a convention to determine its change trajectory. We argue that the change trajectories of constitutional conventions are not entirely unpredictable but can be traced to particular kinds of change events and the particular set of features inherent to that convention.