bluuebunny/crossref_metadata_2025_split huggingface dataset:
BP Gulf of Mexico Neogene Astronomically-tuned Time Scale (BP GNATTS)
Authors: Bergen J.A. , Truax S. , de Kaenel E. , Blair S. , Browning E. , Lundquist J. , Boesiger T. , Bolivar M. , Clark K. 
Published: April 2019

AbstractThis paper introduces an integrated Neogene microfossil biostratigraphic chart developed within post-merger BP for the Gulf of Mexico Basin and is the first published industrial framework “fully-tuned” to orbital periodicities. Astronomical-tuning was accomplished through a 15-year research program on the Ocean Drilling Program’s (ODP) Leg 154 sediments (offshore NE Brazil) with sampling resolution for calcareous nannofossils and planktonic foraminifera ∼20 k.y. and 40 k.y. (thousand year), respectively. This framework extends from the Late Oligocene (25.05 Ma) to Recent at an average Chart Horizon resolution for the Neogene of 144 k.y., approximately double that of published Gulf of Mexico biostratigraphic charts and a fivefold increase over the highest resolution global calcareous microfossil biozonation. Such resolution approximates that of fourth to fifth order parasequences and is a critical component in the verification of seismic correlations between mini-basins in the deep-water Gulf of Mexico. Its utility in global time-scale construction and correlation has been proven, in part, by application of the scheme in full to internal research for the Oligocene–Miocene boundary interval on the global boundary stratotype section and point (GSSP) in northern Italy and offshore wells in the eastern Mediterranean Sea. This step change in Neogene resolution, now at the level of cyclostratigraphy (the orbital periodicity of eccentricity) and the magnetostratigraphic chron, demonstrates the potential for calcareous microfossil biostratigraphy to more consistently reinforce correlations of these time scale parameters. The integration of microfossil disciplines, consistent taxonomies, and rigorous analytical methodologies are all critical to obtaining and reproducing this new level of biostratigraphic resolution.
The Kulanaokuaiki-3 tephra, 900 CE: Products of a remarkably energetic pyroclastic eruption at Kīlauea Volcano, Hawaiʻi, USA
Authors: Fiske Richard S. , Rose Timothy R. , Swanson Donald A. , Andrews Benjamin J. , Nichols Alexander R.L. 
Published: April 2019

Abstract
Eruptions of Kīlauea Volcano, Hawaiʻi, USA, can be more powerful than previously recognized. The Kulanaokuaiki-3 (K-3) eruption, ca. 900 CE, consisted of two episodes that dispersed lithic wall-rock clasts (Episode 1) and dominantly scoria (Episode 2; VEI-3) across >65 km2 southeast of the summit. Dense 12 cm blocks of Episode 1 fell 8–10 km from the summit vent, and 2–4 cm lithic lapilli reached the coastline, 17 km from the vent. The Episode 2 deposit is chemically zoned, indicating orderly eruption from a layered magma body analogous to the 1959 Kīlauea Iki lava lake. Olivine-hosted melt inclusions suggest a magma body within 1 km of the surface. Some Episode 1 lithic clasts have magmatic rinds chemically similar to the early Episode 2 scoria, suggesting a genetic link, although each had a distinct eruption mechanism. Southeastward tephra dispersal counter to NE trade winds implies dispersal by jet-stream winds. The dispersal of lithic clasts in Episode 1 cannot be explained by ballistic trajectories or by transport in a buoyant plume. Calculations instead indicate that a jet from a vent with a minimum diameter of 50 m, a velocity of at least 300 m/s, and a duration of ∼60 s could have lifted the lithic clasts into the jet stream. Isopach and isopleth maps for Episode 2 indicate a subplinian column height of 14–18 km and a duration of 2–3 h, assuming constant flux. The Episode 1 conduit probably intersected or otherwise lowered pressure within a compositionally zoned magma body, triggering eruption of the Episode 2 scoria.
Predictive models for the deep geometry of a thick-skinned thrust matched to crustal structure: Wind River Range, western USA
Authors: Groshong Richard H. , Porter Ryan 
Published: April 2019

AbstractThe ability of models designed to use near-surface structural information to predict the deep geometry of a faulted block is tested for a thick-skinned thrust by matching the surface geometry to the crustal structure beneath the Wind River Range, Wyoming, USA. The Wind River Range is an ∼100-km-wide, thick-skinned rotated basement block bounded on one side by a high-angle reverse fault. The availability of a deep seismic-reflection profile and a detailed crustal impedance profile based on teleseismic receiver-function analysis makes this location ideal for testing techniques used to predict the deep fault geometry from shallow data. The techniques applied are the kinematic models for a circular-arc fault, oblique simple-shear fault, shear fault-bend fold, and model-independent excess area balancing. All the kinematic models imply that the deformation cannot be exclusively rigid-body rotation but rather require distributed deformation throughout some or all of the basement. Both the circular-arc model and the oblique-shear models give nearly the same best fit to the master fault geometry. The predicted lower detachment matches a potential crustal detachment zone at 31 km subsea. The thrust ramp is located close to where this zone dies out to the southwest. The circular-arc model implies that the penetrative deformation could be focused at the trailing edge of the basement block rather than being distributed uniformly throughout and thus helps to explain the line of second-order anticlines along the trailing edge of the Wind River block.Key points: (1) The circular-arc fault model and the oblique-shear model predict a lower detachment for the Wind River rotated block to be ∼31 km subsea, consistent with the crustal structure as defined by teleseismic receiver-function analysis. The thrust ramp starts where this zone dies out. (2) The kinematic models require distributed internal deformation within the basement block, probably concentrated at the trailing edge. (3) The uplift at the trailing edge of the rotated block is explained by the circular-arc kinematic model as a requirement to maintain area balance of a mostly rigid block above a horizontal detachment; the oblique-shear model can explain the uplift as caused by displacement on a dipping detachment.
Enterosgel for the treatment of adults with acute diarrhoea in a primary care setting: a randomised controlled trial
Authors: Howell Carol Angela , Markaryan Elena , Allgar Victoria , Kemppinen Anu , Khovanov Aleksander , Pandya Preeti , Arasaradnam Ramesh 
Published: April 2019

BackgroundAcute intestinal infections are common conditions causing high morbidity and mortality especially in the young and elderly, resulting in a significant burden on health service resources and the economy. Current National Institute for Health and Care Excellence guidance are fluid and nutritional management; however, this does not reduce the duration of diarrhoea and the challenge of treating diarrhoea itself remains. We investigated the efficacy, tolerability and safety of intestinal adsorbent Enterosgel (polymethylsiloxane polyhydrate) compared with standard care in adults with acute diarrhoea.MethodsThis was a randomised controlled trial enrolling 105 subjects to receive the medical device Enterosgel up to six times daily for up to 8 days with standard care (oral rehydration solution), or standard care alone. The primary endpoint was the duration of diarrhoea (hours) from randomisation to first non-loose stool in the Enterosgel versus control group.ResultsA total of 51 subjects were randomised into the Enterosgel group and 54 into the control group, after excluding missing data, the data from 43 subjects in each group were analysed. Duration of diarrhoea was significantly shorter in the Enterosgel group at 27 hours versus 39 hours in the control group (HR was 1.74 [95% CI 1.06 to 2.87]) (p=0.03). This yielded a number needed to treat value of 5. Enterosgel was well tolerated and safe with no serious adverse events. One serious diarrhoea-related event resulting in hospitalisation was reported in the control group.ConclusionsEnterosgel treatment was associated with a significant reduction in the duration of diarrhoea in adults with patient-reported acute diarrhoea, compared with standard care. These findings support the role of Enterosgel in acute diarrhoea especially in vulnerable groups where rapid resolution of symptoms is required. Reduction in symptom duration could translate to less healthcare costs and socioeconomic burden.Trial registration numberISRCTN20758708
Persistence with opioids post discharge from hospitalisation for surgery in Australian adults: a retrospective cohort study
Authors: Roughead Elizabeth Ellen , Lim Renly , Ramsay Emmae , Moffat Anna K , Pratt Nicole L 
Published: April 2019

ObjectiveTo determine time to opioid cessation post discharge from hospital in persons who had been admitted to hospital for a surgical procedure and were previously naïve to opioids.Design, setting and participantsRetrospective cohort study using administrative health claims database from the Australian Government Department of Veterans’ Affairs (DVA). DVA gold card holders aged between 18 and 100 years who were admitted to hospital for a surgical admission between 1 January 2014 and 30 December 2015 and naïve to opioid therapy prior to admission were included in the study. Gold card holders are eligible for all health services that DVA funds.Main outcome measuresThe outcome of interest was time to cessation of opioids, with follow-up occurring over 12 months. Cessation was defined as a period without an opioid prescription that was equivalent to three times the estimated supply duration. The proportion who became chronic opioid users was defined as those who continued taking opioids for greater than 90 days post discharge. Cumulative incidence function with death as a competing event was used to determine time to cessation of opioids post discharge.ResultsIn 2014–2015, 24 854 persons were admitted for a surgical admission. In total 3907 (15.7%) were discharged on opioids. In total 3.9% of those discharged on opioids became chronic users of opioids. The opioid that the patients were most frequently discharged with was oxycodone; oxycodone alone accounted for 43%, while oxycodone with naloxone accounted for 8%.ConclusionsOpioid initiation post-surgical hospital admission leads to chronic use of opioids in a small percentage of the population. However, given the frequency at which surgical procedures occur, this means that a large number of people in the population may be affected. Post-discharge assessment and follow-up of at-risk patients is important, particularly where psychosocial elements such as anxiety and catastrophising are identified.
What enables older people to continue with their falls prevention exercises? A qualitative systematic review
Authors: Finnegan Susanne , Bruce Julie , Seers Kate 
Published: April 2019

ObjectivesTo review the qualitative literature that explores the barriers and facilitators to continued participation in falls prevention exercise after completion of a structured exercise programme.DesignA systematic literature review with thematic synthesis of qualitative studies exploring older adults’ experiences of continued participation in falls prevention exercise.Data sourcesComprehensive searches were conducted in MEDLINE, PSYCHinfo, AMED, ASSIA, CINAHL and EMBASE from inception until November 2017. Additional studies were identified via searches of reference lists and citation tracking of relevant studies.Eligibility criteriaQualitative or mixed methods studies exploring experiences of community-dwelling older adults (65 years and over) participation in a falls prevention exercise programme including their experience of ongoing participation in exercise after the completion of a structured exercise programme.Data extraction and synthesisKey characteristics including aim, participant characteristics, method of data collection, underpinning qualitative methodology and analytical approach were extracted and independently checked. Thematic synthesis was used to integrate findings.ResultsFrom 14 studies involving 425 participants, we identified three descriptive themes: identity, motivators/deterrents and nature of the intervention and one overarching analytical theme: agency.ConclusionsOlder people have their own individual and meaningful rationale for either continuing or stopping exercise after completion of a structured falls prevention exercise programme. Exploring these barriers and facilitators to continued exercise is key during the intervention phase. It is important that health care professionals get to know the older person’s rationale and offer the best evidence-based practice and support to individuals, to ensure a smooth transition from their structured intervention towards longer-term exercise-related behaviour.PROSPERO registration numberCRD42017082637.
Assessing the severity of methamphetamine use disorder beyond the subjective craving report: the role of an attention bias test
Authors: Liang Qiongdan , Yuan Tifei , Cao Xinyu , He Hao , Yang Jiemin , Yuan Jiajin 
Published: April 2019

BackgroundMethamphetamine (MA) is one of the most commonly abused illicit psychostimulant drugs and MA use disorder constitutes a universal health concern across the world. Despite many intervention approaches to MA use disorder, the indicator of addiction severity is mainly limited to subjective craving score to drug-related cues, which is influenced by many factors such as social approval and self-masking.AimThe present study investigates whether self-reported craving for drug use in response to MA cues is a reliable indicator for addiction severity in MA users, and then tests the validity of the cue-induced attention bias test in addiction severity assessment.MethodsFifty-two male MA users completed the cue-induced craving test and attention bias task, and were required to report clinical characteristics of addiction severity. For the attention bias test, subjects were required to discriminate the letter superimposed onto MA use-related or neutral scenes. The reaction time delay during MA-use condition relative to neutral condition was used as an index of the attention bias.ResultsThe results showed that 24 of the 52 MA users rated non-zero in cue-induced craving test, and they showed a significant attention bias to drug-related pictures. However, the other 28 users who rated zero in cue-induced craving evaluation showed a similar attention bias to drug-related cues. In addition, the attention bias to MA use-related cues was significantly and positively correlated with the clinical indexes of addiction severity, but the relationship was absent between subjective craving evaluation and the indexes of addiction severity.ConclusionThese results suggest that attention bias to MA cues may be a more reliable indicator than experiential craving report, especially when subjective craving is measured in the compulsory rehabilitation centre.
Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease
Authors: Akyea Ralph Kwame , Kai Joe , Qureshi Nadeem , Iyen Barbara , Weng Stephen F 
Published: April 2019

ObjectiveTo assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk of cardiovascular disease (CVD).MethodsProspective cohort study of 165 411 primary care patients, from the UK Clinical Practice Research Datalink, who were free of CVD before statin initiation, and had at least one pre-treatment LDL-C within 12 months before, and one post-treatment LDL-C within 24 months after, statin initiation. Based on current national guidelines, <40% reduction in baseline LDL-C within 24 months was classified as a sub-optimal statin response. Cox proportional regression and competing-risks survival regression models were used to determine adjusted hazard ratios (HRs) and sub-HRs for incident CVD outcomes for LDL-C response to statins.Results84 609 (51.2%) patients had a sub-optimal LDL-C response to initiated statin therapy within 24 months. During 1 077 299 person-years of follow-up (median follow-up 6.2 years), there were 22 798 CVD events (12 142 in sub-optimal responders and 10 656 in optimal responders). In sub-optimal responders, compared with optimal responders, the HR for incident CVD was 1.17 (95% CI 1.13 to 1.20) and 1.22 (95% CI 1.19 to 1.25) after adjusting for age and baseline untreated LDL-C. Considering competing risks resulted in lower but similar sub-HRs for both unadjusted (1.13, 95% CI 1.10 to 1.16) and adjusted (1.19, 95% CI 1.16 to 1.23) cumulative incidence function of CVD.ConclusionsOptimal lowering of LDL-C is not achieved within 2 years in over half of patients in the general population initiated on statin therapy, and these patients will experience significantly increased risk of future CVD.
Impact of changes in heart rate with age on all-cause death and cardiovascular events in 50-year-old men from the general population
Authors: Chen Xiao-jing , Barywani Salim Bary , Hansson Per-Olof , Östgärd Thunström Erik , Rosengren Annika , Ergatoudes Constantinos , Mandalenakis Zacharias , Caidahl Kenneth , Fu Michael Lx 
Published: April 2019

BackgroundResting heart rate (RHR), a known cardiovascular risk factor, changes with age. However, little is known about the association between changes in RHR and the risk of cardiovascular events. The purpose of this study was therefore to assess the impact of RHR at baseline, and the change in RHR over time, on the risk of all-cause death and cardiovascular events.DesignA random population sample of men born in 1943 who were living in Gothenburg, Sweden was prospectively followed for a 21-year period.MethodsParticipants were examined three times: first in 1993 and then re-examined in 2003 and 2014. At each visit, a clinical examination, an ECG and laboratory analyses were performed. Change in RHR between 1993 and 2003 was defined as a decrease if RHR decreased by 5 beats per minute (bpm), an increase if RHR increased by 5 bpm or stable if the RHR change was<4bpm).ResultsParticipants with a baseline RHR of >75 bpm in 1993 had about a twofold higher risk of all-cause death (HR 2.3, CI 1.2 to 4.7, p=0.018), cardiovascular disease (CVD) (HR 1.8, CI 1.1 to 3.0, p=0.014) and coronary heart disease (CHD) (HR 2.2, CI 1.1 to 4.5, p=0.025) compared with those with<55 bpm in 1993. Participants with a stable RHR between 1993 and 2003 had a 44% decreased risk of CVD (HR 0.56, CI 0.35 to 0.87, p=0.011) compared with participants with an increasing RHR. Furthermore, every beat increase in heart rate from 1993 was associated with a 3% higher risk for all-cause death, 1% higher risk for CVD and 2% higher risk for CHD.ConclusionHigh RHR was associated with an increased risk of death and cardiovascular events in men from the general population. Moreover, individuals with an increase in RHR between 50 and 60 years of age had worse outcome.
Early experiences with the use of continuous erector spinae plane blockade for the provision of perioperative analgesia for pediatric liver transplant recipients
Authors: Moore Robert P , Liu Chyong-jy Joyce , George Preeta , Welch Timothy P , AuBuchon Jacob D , Jiao York , Drobish Julie K 
Published: April 2019

ObjectivePediatric liver transplantation presents a number of anesthetic challenges, especially in providing adequate perioperative analgesia. In an effort to reduce opioid consumption and improve functional outcomes following pediatric liver transplantation, we have instituted a novel analgesia protocol centered on the provision of continuous regional analgesia with erector spinae plane (ESP) blockade.CasesWe describe preincisional bilateral ESP catheter placement in two pediatric patients undergoing orthotopic liver transplantation. The first case was a 12-year-old boy with maple syrup urine disease undergoing initial transplantation and the second case was an 8-year-old boy who underwent an 11 hours complex redo liver transplant in the setting of glycogen storage disease type 1A requiring initial liver transplant in 2014. The 8-year-old boy presented to the operating suite with acute Budd-Chiari syndrome with comorbid ascites and a large right pleural effusion. In both cases, ESP blockade resulted in good analgesia, markedly reduced intraoperative and postoperative opioid consumption as compared with institutional data and published rates of consumption and was associated with rapid return of bowel function.ConclusionsThese early experiences suggest a role for continuous ESP blockade to improve analgesia and potentially change the paradigm of treatment in this fragile patient population. The technique should be considered in similar interventions. Further study will be undertaken to validate our observation.
A Phase I/II Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib for Relapsed Refractory Acute Myeloid Leukemia
Authors: Advani Anjali S. , Cooper Brenda , Visconte Valeria , Elson Paul , Chan Ricky , Carew Jennifer , Wei Wei , Mukherjee Sudipto , Gerds Aaron , Carraway Hetty , Nazha Aziz , Hamilton Betty , Sobecks Ronald , Caimi Paolo , Tomlinson Benjamin , Malek Ehsan , Little Jane , Miron Alexander , Pink John , Maciejewski Jaroslaw , Unger Allison , Kalaycio Matt , de Lima Marcos , Sekeres Mikkael A. 
Published: April 2019

Abstract

Purpose:
The prognosis of patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) remains poor, and novel therapies are needed. The proteasome pathway represents a potential therapeutic target. A phase I trial of the second-generation proteasome inhibitor ixazomib in combination with MEC (mitoxantrone, etoposide, and cytarabine) was conducted in patients with R/R AML.

Patients and Methods:
Dose escalation of ixazomib was performed using a standard 3 × 3 design. Gene-expression profiling was performed on pretreatment and posttreatment bone marrow or blood samples.

Results:
The maximum tolerated dose of ixazomib in combination with MEC was 1.0 mg. The dose limiting toxicity was thrombocytopenia. Despite a poor risk population, the response rate [complete remission (CR)/CR with incomplete count recovery (CRi)] was encouraging at 53%. Gene-expression analysis identified two genes, IFI30 (γ-interferon inducible lysosomal thiol reductase) and RORα (retinoic orphan receptor A), which were significantly differentially expressed between responding and resistant patients and could classify CR.

Conclusions:
These results are encouraging, but a randomized trial is needed to address whether the addition of ixazomib to MEC improves outcome. Gene-expression profiling also helped us identify predictors of response and potentially novel therapeutic targets.