bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agricultural firm survival: The case of farmer cooperatives in the United States
Authors: Grashuis Jasper 
Published: June 2019

AbstractThe number of farmer cooperatives in the United States is declining, but empirical investigations of cooperative firm survival have been scarce. With demographic, financial, and strategic characteristics as possible explanations, we conduct survival analysis in relation to 950 U.S. farmers cooperatives for the 2005–2018 period. Following the results of our Cox proportional hazard regressions, we find (a) relatively young and old farmer cooperatives are more susceptible to exit; (b) the relationship of membership size to the survival rate of farmer cooperatives is U‐shaped; (c) farmer cooperatives with intangible asset portfolios have lower survival probabilities; and (d) the survival function of farmer cooperatives is not explained significantly by efficiency, leverage, or liquidity. Overall, we use our findings to inform recommendations in terms of cooperative firm behavior, in particular in relation to member heterogeneity and strategic orientation.
Fifteen year overall survival rates after autologous stem cell transplantation for AL amyloidosis
Authors: Sidana Surbhi , Sidiqi M. Hasib , Dispenzieri Angela , Buadi Francis K. , Lacy Martha Q. , Muchtar Eli , Dingli David , Hayman Suzanne R. , Gonsalves Wilson I. , Kapoor Prashant , Leung Nelson , Warsame Rahma , Kourelis Taxiarchis V. , Wolf Robert C. , Hogan William J. , Kumar Shaji K. , Gertz Morie A. 
Published: June 2019

AbstractIn appropriately selected patients with AL amyloidosis, autologous stem cell transplant (ASCT) is an established treatment modality with excellent outcomes and decreasing transplant related mortality (TRM) over time. We report on 15‐year overall survival (OS) in 159 patients undergoing ASCT from 1996 to 2003, with median follow up of 17.1 years. Day 100 TRM was 13.2% (n = 21). The OS of ≥15 years was observed in 30% (47/159) of patients. Patients surviving ≥15 years were younger (53 vs 56 years, P = .02), less likely to have lambda as the involved light chain (62% vs 78%, P = .03) and were less likely to have heart involvement (32% vs 56%, P = .005). Median OS of patients with heart involvement vs not was 4.0 vs 11.1 years, P = .006 and actuarial 15‐year OS was 23% vs 43%, respectively. A higher proportion of patients with OS ≥15 years received full‐dose melphalan conditioning (81% vs 61%, P = .01), and achieved day 100 complete response (CR) (64% vs 24%, P < .001). Median OS amongst patients who achieved CR vs not was 19.3 vs 5.4 years, P < .001. Heart involvement, receiving full‐dose melphalan and achieving CR remained independent predictors of OS. AL amyloidosis and related complications were the cause of death in 52% of patients overall (1‐5 years post‐transplant: 81%; 5‐10 years: 62% and 10‐15 years: 55%). These results reinforce the key role of ASCT in AL amyloidosis. With improvements in TRM and more options for relapsed disease, we expect the long‐term survival post‐transplant to improve significantly in the future.
Prevalence of, and biochemical and anthropometric risk factors for, dyslipidemia in children and adolescents aged 7 to 18 years in China: A cross‐sectional study
Authors: He Huijing , Pan Li , Du Jianwei , Liu Feng , Jin Yuming , Ma Jingang , Wang Li , Jia Pengben , Hu Zhiping , Shan Guangliang 
Published: June 2019

AbstractObjectiveThis study aimed to investigate the prevalence of dyslipidemia and its risk factors in children and adolescents aged 7 to 18 years in China.MethodsA cross‐sectional study was conducted from November, 2013 to July, 2014. A total of 2283 children and adolescents from urban and rural areas in Hainan (South China) and Shaanxi Provinces (Northwest China) were selected using multi‐stage stratified cluster sampling method. Each participant underwent anthropometric and serum biochemical tests which included serum lipids and hepatitis B virus surface antigen (HBsAg).ResultsThe overall prevalence of high total cholesterol (TC), high triglyceride (TG), high low‐density lipoprotein cholesterol (LDL‐C), low high‐density lipoprotein cholesterol (HDL‐C), hyperlipidemia and dyslipidemia were 6.5%, 7.5%, 5.2%, 9.1%, 14.3%, and 20.6%, respectively. After standardization by age, girls had higher prevalence of high TC (8.2%), high LDL‐C (6.6%), and hyperlipidemia (16.4%), but lower prevalence of low HDL‐C (8.21%) than boys (4.2%, 3.4%, 11.9%, and 11.3%, respectively). The risk of dyslipidemia increased with age (OR = 1.067, 95% CI: 1.030‐1.106). Boys had a decreased risk of dyslipidemia (OR = 0.798, 95% CI: 0.640‐0.994). The restricted cubic spline revealed a linear relationship between BMI and the risk of dyslipidemia (P < .001). Subjects who were HBsAg positive had higher risk of dyslipidemia (OR = 1.550, 95% CI: 1.050‐2.287) compared with those who were HBsAg negative.ConclusionsOur study highlights the high prevalence of dyslipidemia in youth in China, and is the first study to reveal a positive association between positive status for HBsAg and abnormal lipid levels in children and adolescents.
Bipolarolides A–G: Ophiobolin‐Derived Sesterterpenes with Three New Carbon Skeletons from Bipolaris sp. TJ403‐B1
Authors: Liu Mengting , Sun Weiguang , Shen Ling , He Yan , Liu Junjun , Wang Jianping , Hu Zhengxi , Zhang Yonghui 
Published: June 2019

AbstractBipolarolides A–G (1–7), seven novel ophiobolin‐derived sesterterpenes with three new types of skeletons, were characterized from fungus Bipolaris sp. TJ403‐B1. Their structures were determined via spectroscopic analyses, X‐ray crystallography, and quantum chemical 13C NMR and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 were uniquely defined by a multicyclic caged oxapentacyclo[9.3.0.01,6.05,9.18,12]pentadecane‐bridged system. Compounds 3 and 4 featured an unprecedented 5‐5‐5‐5‐fused core skeleton, while 3 also contained an unexpected C‐3–C‐14 oxygen bridge to construct the caged architecture. Compounds 5–7 form a new class of highly modified pentacyclic oxaspiro[4.4]nonane‐containing sesterterpene‐alkaloid hybrids. Their biosynthetic pathways and potential HMG‐CoA reductase inhibitory and antimicrobial activities are also discussed.
Redescription of Brachiosaurid Sauropod Dinosaur Material From the Upper Jurassic Morrison Formation, Colorado, USA
Authors: D'Emic Michael D. , Carrano Matthew T. 
Published: June 2019

ABSTRACTLike many long‐standing dinosaur taxa, Brachiosaurus altithorax from the Upper Jurassic Morrison Formation of North America suffers from taxonomic issues stemming from a relatively incomplete holotype. Lack of anatomical overlap has precluded definitive referral of important specimens, including a mostly complete skull discovered in 1883. We redescribe this skull and some other significant brachiosaurid specimens based on new preparation and computed tomographic (CT) data. We argue that these elements are most parsimoniously referred to B. altithorax. Including these tentatively referred elements in a phylogenetic analysis does not alter the hypothesized relationships of B. altithorax, congruent with the presence of a single brachiosaurid taxon across western North America in the Late Jurassic. Based on CT data, we estimate that B. altithorax had a slower tooth replacement rate than Camarasaurus or the diplodocoids it shared Morrison Formation landscapes with, which suggests a difference in diet and/or feeding strategy. Anat Rec, 303:732–758, 2020. © 2019 Wiley Periodicals, Inc.
Gender comparative research on learning strategies applying the cognitive‐motor model methodology and VISIR remote lab
Authors: Blazquez‐Merino Manuel , Garcia‐Loro Felix , Plaza‐Merino Pedro , López‐Rey Africa , San Cristobal‐Ruiz Elio , Castro‐Gil Manuel A. , Albert Mª José 
Published: June 2019

AbstractThe research work hereby presented shows some findings about the different ways used by girls and boys, at secondary school, to assimilate the electricity concepts and electric magnitudes to be able to design and assemble electric circuits. The methodology applied to learning, the cognitive‐motor model (CMM), is also presented, and it is based on the mutual interaction of cognitive skills and motor capabilities. Students have followed a specific course designed under CMM specifications. The course contains a combination of theoretical activities and practical tasks by means of which cognitive and motor skills have been measured. To carry out the practical tasks, the Virtual Instrument Systems in a reality remote lab have been used by students as the technical resource. In the study, different learning strategies between male and female students, what affects each gender effectiveness, and learning performance have been found.
PD‐L1 and PD1 expression in post‐transplantation lymphoproliferative disease (PTLD) of childhood and adolescence: An inter‐ and intra‐individual descriptive study covering the whole spectrum of PTLD categories
Authors: Schiefer Ana‐Iris , Salzer Elisabeth , Füreder Anna , Szepfalusi Zsolt , Müller‐Sacherer Thomas , Huber Wolf‐Dietrich , Michel‐Behnke Ina , Lawitschka Anita , Pichler Herbert , Mann Georg , Hutter Caroline , Simonitsch‐Klupp Ingrid , Attarbaschi Andishe 
Published: July 2019

AbstractTherapy of children with post‐transplantation lymphoproliferative disorder (PTLD) after hematopoietic stem cell (HSCT) and solid organ transplantation (SOT) can be challenging. In this retrospective study, we investigated PD‐L1 and PD1 expression in all PTLD categories of childhood and adolescence to see whether checkpoint inhibition with PD‐L1/PD1 inhibitors may serve as a therapy option. We included 21 patients aged 19 years or younger (at date of transplant) with PTLD following SOT or HSCT having adequate tumor samples available (n = 29). Using immunohistochemistry, we evaluated PD‐L1/PD1 expression on both tumor cells and cells of the microenvironment in all samples. Availability of consecutively matched tumor samples during 6 of 21 patients' disease courses also allowed an intra‐individual assessment of PD‐L1/PD1 expression. We observed lower PD‐L1 and higher PD1 expression in non‐destructive lesions, and higher PD‐L1 and lower PD1 expression in polymorphic and, in particular, in monomorphic PTLD, mostly diffuse large B‐cell lymphomas (DLBCL, n = 10/21). The amount of PD‐L1‐ and PD1‐positive cells changed in the opposite way in sequential biopsies of the same individual correlating well with the PTLD category. This is the first comprehensive pediatric study assessing PD‐L1 and PD1 expression on tumor cells and in the microenvironment of PTLD including not only monomorphic, but also non‐destructive early lesions. PD‐L1 expression of the tumor cells inversely correlated with PD1 expression in surrounding tissues, with the highest expression in DLBCL. Since PTLD can be therapeutically challenging, our results indicate a potential efficacy of checkpoint inhibitors if standard immune‐ and/or chemotherapy fail or are impossible. We therefore recommend routine staining of PD‐L1 and PD1 in all PTLD categories.
Predictive value of combining the SYNTAX score with reactive hyperemia index in patients with acute coronary syndrome undergoing percutaneous coronary intervention
Authors: He Yun , Cheng X. F. , Wang K. , Liu T. , Fan H. P. , Pan W. X. , He P. X. , Jin Jun 
Published: June 2019

AbstractObjectiveTo investigate the predictive value of SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) score (SS) combined with reactive hyperemia index (RHI) in predicting 2‐year major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).BackgroundBoth SS and RHI are good predictors of MACE; however, it is unknown whether combining SS and RHI could improve predictability of MACE in patients with ACS undergoing PCI.MethodsWe undertook a prospective study in 401 ACS patients that underwent PCI. The RHI‐SYNTAX score (RSS) was calculated by categorizing and summing up the RHI and SS of individual patients. Patients with RHI < 1.67 are given 1 point, RHI ≥ 1.67 given 0 points, and those with SS ≤ 22 scored as 0 and SS > 22 as 1 point. Patients were classified into three groups: low RSS (group 0), moderate RSS (group 1), and high RSS (group 2).ResultsAmong patients in the low, moderate, and high groups, the 2‐year rates of MACE were 5.50, 10.66, and 23.33%, respectively (p < .0001). Total revascularization rates were 1.83, 2.54, and 8.89%, respectively (p = .015). Ischemic stroke rates were 0.00, 3.67, and 5.56%, respectively (p = .031). By multivariate analysis, the RSS was an independent predictor of 2‐year MACE (hazard ratio: 2.09, 95% CI: 1.36–3.21, p = .001). Receiver‐operator characteristic analysis indicated that the area under the curve significantly improved from 0.63 to 0.69, when RHI was added to SS (p < .0001).ConclusionsRSS is correlated with 2‐year MACE in patients presenting with ACS undergoing PCI.
The efficacy and safety of cangrelor in single vessel vs multivessel percutaneous coronary intervention: Insights from CHAMPION PHOENIX
Authors: Yong Celina M. , Sundaram Vandana , Abnousi Freddy , Olivier Christoph B. , Yang Jaden , Stone Gregg W. , Steg Philippe G. , Michael Gibson C. , Hamm Christian W. , Price Matthew J. , Deliargyris Efthymios N. , Prats Jayne , White Harvey D. , Harrington Robert A. , Bhatt Deepak L. , Mahaffey Kenneth W. ,   on behalf of the CHAMPION PHOENIX Investigators
Published: June 2019

AbstractBackgroundThe intravenous, rapidly acting P2Y12 inhibitor cangrelor reduces the rate of ischemic events during PCI with no significant increase in severe bleeding. However, the efficacy and safety of cangrelor compared with clopidogrel in patients treated with single vessel (SV)‐percutaneous coronary intervention (PCI) or multivessel (MV)‐PCI remains unexplored.MethodsWe studied the modified intention‐to‐treat population of patients from the CHAMPION PHOENIX trial who were randomized to either cangrelor or clopidogrel. We used logistic regression and propensity score matching to evaluate the effect of cangrelor compared with clopidogrel on the primary efficacy outcome (composite of death, myocardial infarction, ischemia‐driven revascularization, or stent thrombosis) at 48 hours. The safety outcome was moderate or severe Global Utilization of Streptokinase and tPA for Occluded Arteries bleeding at 48 hours.HypothesisCangrelor is as efficacious and safe as clopidogrel in both SV and MV PCI.ResultsAmong 10 854 patients, 9204 (85%) underwent SV‐ and 1650 (15%) MV‐PCI. After adjustment, cangrelor was associated with similar reductions vs clopidogrel in the primary efficacy outcome in patients undergoing SV‐PCI (4.5% vs 5.2%; odds ratio [OR] 0.81 [0.66‐0.98]) or MV‐PCI (6.1% vs 9.8%, OR 0.59 [0.41‐0.85]; Pint 0.14). Similar results were observed after propensity score matching (SV‐PCI: 5.5% vs 5.9%, OR 0.93 [0.74‐1.18]; MV‐PCI: 6.2% vs 8.9%, OR 0.67 [0.44‐1.01]; Pint 0.17). There was no evidence of heterogeneity in the treatment effect of cangrelor compared with clopidogrel for the safety outcome.ConclusionsIn patients undergoing SV‐ or MV‐PCI, cangrelor was associated with similar relative risk reductions in ischemic complications and no increased risk of significant bleeding compared with clopidogrel, which highlights the expanding repertoire of options for use in complex PCI.
A computational model for hepatotoxicity by coupling drug transport and acetaminophen metabolism equations
Authors: Franiatte Sylvain , Clarke Richard , Ho Harvey 
Published: June 2019

AbstractThe spatial distributions of cytochrome P450 (CYP450) and glutathione (GSH) in liver lobules determine the heterogeneous hepatotoxicity of acetaminophen (APAP). Their interplay in conjunction with blood flow is not well understood. In this paper, we integrate a cellular APAP metabolism model with a sinusoidal blood flow to simulate the temporal‐spatial patterns of APAP‐induced hepatotoxicity. The heterogeneous distribution of CYP450 and GSH is modeled by linearly varying their reaction rates along the portal triad to the central vein axis of a sinusoid. We found that the spatial distribution of GSH, glutathione S‐transferases (GSTs), and CYP450 all contributes to the high acetaminophen protein adduct formation at zone 3 of the lobules. The reversed spatial gradients of CYP450 and GSH cause quick depletion of GSH, which is further accelerated by the distribution of GST. The hepatic flow congestion and hyperperfusion however do not seem to play a significant role in the zonal hepatotoxicity. The simulation results may be useful for understanding the APAP‐induced hepatotoxicity and associated pharmaceutical treatment.
Nonadiabatic Dynamics of Hydrogen Diffusion on Cu(001): Classical Mapping Model with Multistate Projection Window in Real Space
Authors: Tao Guohua 
Published: June 2019

AbstractDiffusion of atomic hydrogen on metallic surfaces is a longstanding research topic of both fundamental and practical interests. However, full understanding of the microscopic mechanisms and development of effective strategy for surface dynamics control at the molecular level remain elusive. In this paper, we propose a new nonadiabatic multistate model for surface diffusion based on a real space decomposition scheme by generalizing the classical mapping theory of Meyer and Miller. The model suggests a general multistate perspective on real‐time surface dynamics by mapping it into spatially disjointed windowing functions, which feature the explicit nonadiabatic controllability. Within this framework, the first nonadiabatic molecular dynamics simulation is performed for atomic hydrogen diffusion on the Cu(001) surface, and the nonequilibrium effect of lattice distortion is studied.
Cerebral palsy and bruxism: Effects of botulinum toxin injections—A randomized controlled trial
Authors: Cahlin Birgitta Johansson , Lindberg Christopher , Dahlström Lars 
Published: June 2019

AbstractObjectiveCerebral palsy (CP) includes disturbances in muscular control caused by perinatal brain injury. Masticatory muscle involvement hampers functions such as chewing and talking. Bruxism and temporomandibular disorders are overrepresented. Neuromuscular blocks with botulinum toxin type A (BTX‐A) may alleviate problems due to muscular hyperactivity. The aim was to evaluate masticatory muscle BTX‐A injections in subjects with CP and bruxism.MethodsA prospective, parallel, randomized, placebo‐controlled, and double‐blind trial in 12 patients with CP was performed. End points were alterations in objective and subjective oral capacities after two BTX‐A or corresponding placebo injections. Matched, healthy references were also evaluated.ResultsThe reference group demonstrated stronger and more efficient oral functions compared with the CP group. Subjective and objective oral capacities appeared to vary considerably between CP patients and also over time in this patient group and were poorly correlated. No significant effect of BTX‐A compared with placebo on outcome variables was observed at group level, but continued treatment with BTX‐A was requested by the majority of the patients.ConclusionThe evidence is unable to support the use of BTX‐A for the treatment of affected masticatory muscles in CP, but the findings are inconclusive in certain respects. Larger, more homogeneous groups of CP patients need to be evaluated in future trials.
Cytopathology of anaplastic carcinoma of the pancreas: Review of a rare entity and description of a variant with signet ring cell features
Authors: El Hussein Siba , Khader Samer N. 
Published: June 2019

AbstractAnaplastic carcinoma of the pancreas (ACP) is a rare and aggressive variant of pancreatic ductal adenocarcinoma (PDAC). Several studies have attempted to characterize this subtype through case series or single case reports; however, ACP remains underrecognized by cytopathologists in particular, and often lumped under the umbrella of classic PDAC. Here, we review the most up to date data that literature provides about ACP, to bring familiarity with this entity to the cytopathology practice, and to elucidate the role cytopathologists can play in recognizing and diagnosing this subtype on pancreatic aspiration biopsy, before surgical resection. We also describe a rare case of ACP, demonstrating signet ring cell features, that was diagnosed on fine needle aspiration of a pancreatic mass.
Malignant risk of indeterminate pediatric thyroid nodules—An institutional experience
Authors: Heider Amer , Arnold Stacy , Lew Madelyn , Pang Judy , Rabah Raja , Bruch Steven , Thomas Inas , Menon Ram , Cantley Richard , Davenport Robertson , Jing Xin 
Published: June 2019

AbstractBackgroundFew studies focus on pediatric thyroid nodules categorized under indeterminate diagnostic categories. The current study was conducted to assess the risk of malignancy of indeterminate pediatric thyroid nodules.MethodsA search of the institutional electronic pathology database from 01/2011 to 09/2018 was performed to identify pediatric (<21 years old) thyroid nodules that were interpreted as follicular lesion of undetermined significance (FLUS), suspicious for follicular neoplasm (SFN), or suspicious for malignancy (SFM) and subsequently managed with surgery, repeat fine‐needle aspiration (FNA), or ≥ 6 months of clinical/imaging monitoring. Results of follow‐up (F/U) surgical resections and repeat FNA/Afirma tests, and clinical and radiologic data were collected.ResultsWe identified 46 cases from 42 patients (11‐20 years old, 33 females and 9 males), including 30 FLUS, 10 SFN, and 6 SFM. Twenty‐five FLUS, ten SFN, and six SFM cases underwent surgery. The histology revealed carcinomas in 36% of FLUS, 20% of SFN, and 100% of SFM categories; follicular adenomas in 32% of FLUS and 80% of SFN categories; and benign nodules in 32% of FLUS category. All five nonsurgically treated FLUS cases were considered benign based on the findings of repeat FNA/Afirma tests (n = 3, 3‐22 months F/U) or clinical/radiologic exams (n = 2, 8‐12 months F/U).ConclusionsBased on a limited study cohort, malignancy was identified in 36%, 20%, and 100% of surgically managed pediatric thyroid nodules categorized as FLUS, SFN, and SFM, respectively; suggesting a markedly higher malignant rate than the implied malignant risk for FLUS and SFM categories in adults.
High‐efficiency gravel longshore sediment transport and headland bypassing over an extreme wave event
Authors: McCarroll R.J. , Masselink G. , Wiggins M. , Scott T. , Billson O. , Conley D.C. , Valiente N.G. 
Published: June 2019

AbstractGravel beaches are common throughout the high latitudes, but few studies have examined gravel transport rates, in particular at high energy levels, and no studies have quantified gravel transport around headlands. Here, we present the first complete sediment budget, including supra‐, inter‐ and sub‐tidal regions of the beach, across multiple headland‐separated gravel embayments, combined with hydrodynamic observations, over an extreme storm sequence, representing at least a 1‐in‐50‐year event. Unprecedented erosion was observed (~400 m3 m−1, −6 m vertical), with alongshore flux of 2 × 105 m3, equivalent to annual rates. Total system volume change was determined to the depth of closure and then used to calculate alongshore flux rates. Alongshore wave power was obtained from a wave transformation model. For an open section of coastline, we derive a transport coefficient (CERC formula) of KHs = 0.255 ± 0.05, exceeding estimates in lower‐energy conditions by a factor of 5 or more. We apply this coefficient to rocky segments of the shoreline, determining rates of headland bypass from 0 to 31% of potential flux, controlled by headland extent and toe depth. Our results support the hypothesis that gravel is transported more efficiently at higher energy levels and that a variable rate or threshold approach may be required. Complete coverage and varying morphology make this dataset uniquely suited to improving model predictions of gravel shoreline change. © 2019 John Wiley & Sons, Ltd. © 2019 John Wiley & Sons, Ltd.