bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive and prognostic roles of electrical cardiometry in noninvasive assessments of community‐acquired pneumonia patients with dyspnoea
Authors: Gho Kyungil , Woo Seon Hee , Lee Sang Moog , Park Ki Cheol , Park Gyeong Nam , Kim Jinwoo , Hong Sungyoup 
Published: July 2019

Background:Thoracic impedance monitoring able to detect pneumonia in the very early phase of emerging infiltration prior the patient developed remarkable clinical symptoms. However, no studies have yet been conducted on the usefulness of predicting pneumonia patient outcomes with parameters from electrical cardiometry.Objective:In the present study, we evaluated whether parameters measured by electrical cardiometry can predict clinical outcomes including mortality and length of hospital stay in patients with community‐acquired pneumonia in the emergency department.Methods:Demographic, clinical and laboratory data were collected from enrolled patient. Electrical cardiometry monitoring was done with a portable electrical cardiometry device connected to the body surface sensor. The continuous data from electrical cardiometry were recorded, and parameters were stored on the electrical cardiometry device automatically and then the data were downloaded for further analysis.Results:Thoracic fluid content has shown to be significantly higher in the intensive care unit admission group and in the death group. Expired patients had higher value of thoracic fluid content at emergency department admission. From a receiver operating characteristics curve analysis, thoracic fluid content presented fair AUC values of 0.72 (95% confidence interval, 0.71–0.74) and 0.73 (0.62–0.82) for prediction of 28‐day mortality and intensive care unit admission. Arterial partial pressure of oxygen (PaO2), the ratio of arterial partial pressure of oxygen to inspired oxygen fraction (PaO2/FiO2 ratio) also showed excellent AUC value for prediction of mortality and intensive care unit admission.Conclusion:Electrical cardiometry monitoring indicated new possibility to anticipate prognosis of community‐acquired pneumonia patient. Increased thoracic fluid content value would relate worse outcome of the patient like mortality and intensive care unit admission. Electrical cardiometry monitoring allows real‐time measurements of thoracic fluid content without restraining the patient or invasive catheters.
Arthroscopically-assisted removal of distal centraliser of an MS-30 femoral stem using a cannulated reamer in revision hip arthroplasty
Authors: Papachristos Ioannis V , Acton Kerry 
Published: July 2019

Background: Revision hip arthroplasty can be challenging especially when difficulties to remove distal centralisers arise. Case: We report a case where we removed a well-fixed 1st-generation solid MS-30 distal centraliser combining standard cannulated trauma reamers and arthroscopical guidance. Such case has not been reported in the past and this technical tip can be useful in revision procedures of the specific implant.
Total hip arthroplasty in Parkinson’s disease patients: a propensity score-matched analysis with minimum 2-year surveillance
Authors: Shah Neil V , Solow Maximillian , Lavian Joshua D , Bloom Lee R , Grieco Preston W , Stroud Sarah G , Abraham Roby , Naziri Qais , Paulino Carl B , Maheshwari Aditya V , Diebo Bassel G 
Published: July 2019

Introduction: Parkinson’s disease (PD) patients experience chronic pain related to osteoarthritis at comparable rates to the general population. While total hip arthroplasty (THA) effectively improves pain, functionality, and quality of life in PD patients, long-term outcomes following THA are under-reported. This study sought to investigate whether PD patients have an increased risk of complications and revision following THA in comparison to the general population. Methods: Utilising New York State’s Statewide Planning and Research Cooperative System, all PD patients who underwent THA from 2009 to 2011 with minimum 2-year follow-up were identified. A control group (no-PD) was created via 1:1 propensity score-matching by age, gender, and Charlson/Deyo score. Univariate analysis compared demographics, complications, and revisions. Multivariate binary stepwise logistic regression identified independent predictors of outcomes. Results: 470 propensity score-matched patients (PD: n  = 235; no-PD: n  = 235) were identified. PD patients demonstrated higher rates of overall and postoperative wound infection ( p  < 0.05), with comparable individual and overall complication and revision rates. PD did not increase odds of complications or revisions. PD patients had lengthier hospital stay (4.97 vs. 4.07 days, p  = 0.001) and higher proportion of second primary THA >2-years postoperatively (69.4% vs. 59.6%, p  = 0.027). Charlson/Deyo index was the greatest predictor of any surgical complication (OR  = 1.17, p  = 0.029). Female sex was the strongest predictor of any medical complication (OR  = 2.21, p  < 0.001). Discussion: Despite lengthier hospital stays and infection-related complications, PD patients experienced comparable complication and revision rates to patients from the general population undergoing THA.
Reduction in HbA1c using professional flash glucose monitoring in insulin-treated type 2 diabetes patients managed in primary and secondary care settings: A pilot, multicentre, randomised controlled trial
Authors: Ajjan Ramzi A , Jackson Neil , Thomson Scott A 
Published: July 2019

Aim: Analyse the effects of professional flash glucose monitoring system (FreeStyle Libre Pro™) on glycaemic control in insulin-treated type 2 diabetes. Methods: Primary (n = 17) and secondary care centres (n = 5) randomised 148 type 2 diabetes patients into three groups: (A) self-monitoring of blood glucose (n = 52), (B) self-monitoring of blood glucose and two Libre Pro sensor wears (n = 46) or (C) self-monitoring of blood glucose and four sensor wears (n = 50). Primary endpoint was time in range (glucose 3.9–10 mmol/L) within group C comparing baseline with days 172–187. Predefined secondary endpoints included HbA1c, hypoglycaemia and quality of life measures analysed within and between groups (clinicaltrials.gov, NCT02434315). Results: In group C, time in range in the first 14 days (baseline) and days 172–187 was similar at 15.0 ± 5.0 and 14.1 ± 4.7 h/day (mean ± SD), respectively, (p = 0.1589). In contrast, HbA1c reduced from baseline to study end within group C by 4.9 ± 8.8 mmol/mol (0.44% ± 0.81%; p = 0.0003). HbA1c was also lower in group C compared with A at study end by 5.4 ± 1.79 mmol/mol (0.48% ± 0.16%; p = 0.0041, adjusted mean ± SE), without increased time in hypoglycaemia ( p = 0.1795). Treatment satisfaction scores improved in group C compared with A ( p = 0.0225) and no device-related serious adverse events were reported. Conclusions: Libre Pro can improve HbA1c and treatment satisfaction without increasing hypoglycaemic exposure in insulin-treated type 2 diabetes individuals managed in primary/secondary care centres.
A novel approach involving a microcatheter tip during aneurysmal coil embolization: The Γ (gamma) tip method
Authors: Ohshima Tomotaka , Miyachi Shigeru , Matsuo Naoki , Kawaguchi Reo , Maejima Ryuya , Takayasu Masakazu 
Published: July 2019

Complete and secure occlusion of the entire aneurysmal neck remains a problem despite major advances in the treatment of intracranial aneurysms using endovascular coil embolization. Here, we present our initial clinical experience using a novel strategy for endovascular coil embolization involving a microcatheter tip, known as the “Γ (gamma) tip method,” and compare the in vitro results of this technique with those of conventional straight microcatheters. The microcatheters were bent at a right angle starting 1–2 mm from the length of the tip using a catheter-shaping mandrel and a hot air gun. The tiny right-angled tip is the “Γ tip.” In aneurysm models, we assessed the efficacy of shaping during coil deployment. The Γ-tipped microcatheters demonstrated better movement and oscillation during insertion of the coil into the aneurysm compared with the straight-tipped catheters. Moreover, the Γ-tipped microcatheter provided less coil protrusion into the parent artery and less microcatheter kickback compared with the straight tip. With the Γ-tipped microcatheter, even if the first coil loop migrated into the parent artery, its subsequent dynamic movement routed it back into the aneurysm. The Γ tip method enabled smooth movement of the microcatheter into the aneurysm, demonstrating the safety and security of coil insertion using the Γ tip compared with the conventional straight tip.
Exhaled volatile organic compounds in adult asthma: a systematic review
Authors: Azim Adnan , Barber Clair , Dennison Paddy , Riley John , Howarth Peter 
Published: July 2019

The search for biomarkers that can guide precision medicine in asthma, particularly those that can be translated to the clinic, has seen recent interest in exhaled volatile organic compounds (VOCs). Given the number of studies reporting “breathomics” findings and its growing integration in clinical trials, we performed a systematic review of the literature to summarise current evidence and understanding of breathomics technology in asthma.A PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)-oriented systematic search was performed (CRD42017084145) of MEDLINE, Embase and the Cochrane databases to search for any reports that assessed exhaled VOCs in adult asthma patients, using the following terms (asthma AND (volatile organic compounds AND exhaled) OR breathomics).Two authors independently determined the eligibility of 2957 unique records, of which 66 underwent full-text review. Data extraction and risk of bias assessment was performed on the 22 studies deemed to fulfil the search criteria. The studies are described in terms of methodology and the evidence narratively summarised under the following clinical headings: diagnostics, phenotyping, treatment stratification, treatment monitoring and exacerbation prediction/assessment.Our review found that most studies were designed to assess diagnostic potential rather than focus on underlying biology or treatable traits. Results are generally limited by a lack of methodological standardisation and external validation and by insufficiently powered studies, but there is consistency across the literature that exhaled VOCs are sensitive to underlying inflammation. Modern studies are applying robust breath analysis workflows to large multi-centre study designs, which should unlock the full potential of measurement of exhaled volatile organic compounds in airways diseases such as asthma.
Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis
Authors: Ryu Changwan , Brandsdorfer Caitlin , Adams Taylor , Hu Buqu , Kelleher Dylan W. , Yaggi Madeleine , Manning Edward P. , Walia Anjali , Reeves Benjamin , Pan Hongyi , Winkler Julia , Minasyan Maksym , Dela Cruz Charles S. , Kaminski Naftali , Gulati Mridu , Herzog Erica L. 
Published: July 2019

Sarcoidosis is an unpredictable granulomatous disease in which African Americans disproportionately experience aggressive phenotypes. Mitochondrial DNA (mtDNA) released by cells in response to various stressors contributes to tissue remodelling and inflammation. While extracellular mtDNA has emerged as a biomarker in multiple diseases, its relevance to sarcoidosis remains unknown. We aimed to define an association between extracellular mtDNA and clinical features of sarcoidosis.Extracellular mtDNA concentrations were measured using quantitative PCR for the humanMT-ATP6gene in bronchoalveolar (BAL) and plasma samples from healthy controls and patients with sarcoidosis from The Yale Lung Repository; associations betweenMT-ATP6concentrations and Scadding stage, extrapulmonary disease and demographics were sought. Results were validated in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis cohort.Relative to controls,MT-ATP6concentrations in sarcoidosis subjects were robustly elevated in the BAL fluid and plasma, particularly in the plasma of patients with extrapulmonary disease. Relative to Caucasians, African Americans displayed excessiveMT-ATP6concentrations in the BAL fluid and plasma, for which the latter compartment correlated with significantly higher odds of extrapulmonary disease.Enrichments in extracellular mtDNA in sarcoidosis are associated with extrapulmonary disease and African American descent. Further study into the mechanistic basis of these clinical findings may lead to novel pathophysiologic and therapeutic insights.
Induced polarization response of porous media with metallic particles — Part 9: Influence of permafrost
Authors: Revil André , Razdan Mridul , Julien Stéphane , Coperey Antoine , Abdulsamad Feras , Ghorbani Ahmad , Gasquet Dominique , Sharma Ravi , Rossi Magali 
Published: July 2019

We consider a mixture made of dispersed metallic particles immersed into a background material saturated by an electrolyte. Below the freezing temperature (typically 0°C to [Formula: see text]), a fraction of the liquid water in the pore space is transformed into ice, whereas the salt remains segregated into the liquid-pore water solution. Our goal is to understand how freezing affects the complex conductivity (induced polarization) of such mixtures. Complex conductivity measurements (96 spectra) are performed in a temperature-controlled bath equipped with a high-precision impedance meter. We cover the temperature range from [Formula: see text] to [Formula: see text] to [Formula: see text] and the frequency range from [Formula: see text] to 45 kHz. The spectra are fitted with a double Cole-Cole complex conductivity model. A finite-element model is used to further analyze the mechanisms of polarization by considering an intragrain polarization mechanism for the metallic particles and a change of the conductivity of the background material modeled with an exponential freezing curve. This curve is used to relate the liquid water content to the temperature. In the context of freezing, we test all the aspects of the intragrain polarization model developed in the previous papers of this series, at least for a weakly polarizable background material. The Cole-Cole exponent and the chargeability are observed to be essentially independent of temperature including in freezing conditions. This means that all the relaxation times of the system follow the same temperature dependence and that the chargeability is controlled by the volume fraction of metal. The instantaneous conductivity (high-frequency conductivity) and the relaxation times depend on the temperature in a predictable way, and their product can be considered to be essentially temperature independent. The analytical and numerical models can reproduce the inverse relationship between the relaxation time and the instantaneous conductivity.
Retinoic acid signaling pathways
Authors: Ghyselinck Norbert B. , Duester Gregg 
Published: July 2019

ABSTRACTRetinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or repress transcription of key developmental genes. Genetic studies in mouse and zebrafish embryos that are deficient in RA-generating enzymes or RARs have been instrumental in identifying RA functions, revealing that RA signaling regulates development of many organs and tissues, including the body axis, spinal cord, forelimbs, heart, eye and reproductive tract. An understanding of the normal functions of RA signaling during development will guide efforts for use of RA as a therapeutic agent to improve human health. Here, we provide an overview of RA signaling and highlight its key functions during development.
Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation
Authors: Voltes Adrià , Hevia Covadonga F. , Engel-Pizcueta Carolyn , Dingare Chaitanya , Calzolari Simone , Terriente Javier , Norden Caren , Lecaudey Virginie , Pujades Cristina 
Published: July 2019

ABSTRACT
Cells perceive their microenvironment through chemical and physical cues. However, how the mechanical signals are interpreted during embryonic tissue deformation to result in specific cell behaviors is largely unknown. The Yap/Taz family of transcriptional co-activators has emerged as an important regulator of tissue growth and regeneration, responding to physical cues from the extracellular matrix, and to cell shape and actomyosin cytoskeletal changes. In this study, we demonstrate the role of Yap/Taz-TEAD activity as a sensor of mechanical signals in the regulation of the progenitor behavior of boundary cells during zebrafish hindbrain compartmentalization. Monitoring of in vivo Yap/Taz activity during hindbrain segmentation indicated that boundary cells responded to mechanical cues in a cell-autonomous manner through Yap/Taz-TEAD activity. Cell-lineage analysis revealed that Yap/Taz-TEAD boundary cells decreased their proliferative activity when Yap/Taz-TEAD activity ceased, which preceded changes in their cell fate from proliferating progenitors to differentiated neurons. Functional experiments demonstrated the pivotal role of Yap/Taz-TEAD signaling in maintaining progenitor features in the hindbrain boundary cell population.
Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1
Authors: Tian Yang , Wang Chunying , Chen Shuohua , Liu Jie , Fu Yan , Luo Yongzhang 
Published: July 2019

ABSTRACT
Extracellular heat shock protein 90 alpha (eHsp90α, also known as HSP90AA1) has been widely reported to promote tumor cell motility and tumor metastasis in various types of cancer. Several extracellular proteins and membrane receptors have been identified as interacting proteins of eHsp90α and mediate its pro-metastasis function. However, the regulatory mechanism of eHsp90α activity remains largely unknown. Here, we report that clusterin, a protein newly demonstrated to interact with eHsp90α, modulates eHsp90α signaling. We found that clusterin potentiated the effects of eHsp90α on activation of the AKT, ERK and NF-κB protein families, epithelial-to-mesenchymal transition (EMT) and migration in breast cancer cells. Furthermore, in vivo investigations demonstrated similar synergistic effects of eHsp90α and clusterin on tumor metastasis. Notably, the effects of eHsp90α and clusterin were mediated by low-density lipoprotein receptor-related protein 1 (LRP1). Proximity ligation assay and co-immunoprecipitation experiments demonstrated that clusterin participated in eHsp90α–LRP1 complex formation, which enhanced the binding affinity of eHsp90α to LRP1. Collectively, our data establish a role of clusterin as a newly discovered modulator of eHsp90α, and unravel detailed molecular mechanisms underlying the synergistic metastasis-promoting effects of clusterin and eHsp90α.
The protective effects of antigen-specific IgY on pyocyanin-treated human lymphoma Raji cells
Authors: Susilowati Heni , Artanto Sidna , Yulianto Heribertus Dedy Kusuma , Sosroseno Wihaskoro , Hutomo Suryani 
Published: July 2019

Background:Pyocyanin (PCN), a highly pathogenic pigment produced byPseudomonas aeruginosa, induces caspase 3-dependent human B cell (Raji cells) death. The aim of the present study, therefore, was to assess whether antigen-specific IgY antibodies may be protective on PCN-induced Raji cell death.Methods:Chickens were subcutaneously immunized with Freund's complete adjuvant containing PCN, and then given two boosted immunizations. Anti-PCN IgY antibodies were purified from egg yolk and detected using an agar gel precipitation test (AGPT) and ELISA. Protective effects of antigen-specific IgY on Raji cells were tested using a cell viability assay.Results:AGPT results showed the formation of strong immune complex precipitates, whilst ELISA further confirmed the presence of IgY antibodies specific to PCN at significant concentration. Further experiments showed that anti-PCN IgY antibodies significantly increased PCN-treated Raji cell viability in a dose-dependent fashion (p<0.05).Conclusions:The results of the present study suggest that anti-PCN IgY antibodies may be protective on PCN-induced Raji cell death.
Unclarity and the Intermediates in Plato’s Discussions of Clarity in the Republic
Authors: Smith Nicholas 
Published: July 2019

In this paper, I argue that the two versions of divided line (the first in Book VI and the recalled version in Book VII) create problems that cannot be solved — with or without the hypothesis that the objects belonging to the level of διάνοια on the divided line are intermediates. I also argue that the discussion of arithmetic and calculation does not fit Aristotle’s attribution of intermediates to Plato and provides no support for the claim that Plato had such intermediates in mind when he talked about διάνοια in the Republic. The upshot of my argument is negative: even if Aristotle’s report about Plato and intermediates is correct, there is no evidence for such objects provided in the passages I review from the Republic. If they are to be found in Plato, it will have to be elsewhere that they are found.
ANALISIS EFISIENSI PEMAKAINAN BAHAN BAKAR MESIN INDUK KAPAL PURSE SEINER DI PELABUHAN PENDARATAN NUSANTARA PEKALONGAN
Authors: Sa’id Solichin Djazuli 
Published: July 2019

Solichin Djazuli Sa’id, in this paper explain that fuel consumption for each vessel were variations depending on the size of ships, ships with a larger size will require more fuel for each mile distance the ship with a GT 101 for a distance of 1 mile with a speed of 6 knots require diesel fuel (dieselfue oil ) 6.24 liter, GT 1991: 6.06 liter, GT 80: 5.69 liter, GT 71: 5.13 liter, GT 61;4.74 liter and most economical is the GT 45 is only 3.30 liters per milnyaThe lowest operating costs of fishing vessels is to measure 45GT, 101GT highest. Operational Cost (OC) is the most economical ship with size 45 GT (Modern I).Operational costs are dominating the supply of fuel (diesel) 44%.Profit rate (profit rate) obtained by vessels of 45 GT (Modern I) has a rate of returnabove 15%, the highest in comparison with vessels of above. Keywords: Fuel consumption, operating costs
PENGEMBANGAN ADSORBENT BED UNTUK PENINGKATAN KONDUKTIVITAS TERMAL MELALUI PENAMBAHAN PARTIKEL METAL ALUMINIUM
Authors: Ariwibowo Didik , Sutrisno Sutrisno 
Published: July 2019

Didik Ariwibowo, Sutrisno, in this paper explain that this research is to increase thermal conductivity of a adsorbent bed by adding metal particles in it so that the bed become a granule-mixed bed. The adsorbent bed contains activated-carbon granule and aluminium particles. The research activity include: design and fabrication of adsorbent bed prototype following thermal performance study of the adsorbent bed. The thermal performance study of the adsorbent bed was conducted by varying metal/adsorbent ratio of 5%, 10%, 15% by volume. The result showed that adding 5%, 10%, and 15% aluminium particles into adsorbent bed has increased its thermal conductivity, those are 10,9 Wm-1K-1; 21,9 Wm-1K-1; and 30,9 Wm-1K-1 respectively from 1,6 Wm-1K-1 activated carbon thermal conductivity. The values of experimental thermal conductivity were higher than those of calculated thermal conductivity. The percentage of the difference between experimental thermal conductivity and calculated thermal conductivity decreased as bed surface temperature increased. The relatively higher percentage was in 45% whereas the lower was 10%. The lower range of the difference was 10-20% occurred in 55-65 oC temperature range. Key words: adsorbent bed, metal/adsorbent ratio, thermal conductivity