bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does meeting the Milan criteria at the time of recurrence of hepatocellular carcinoma after curative resection have an impact on prognosis?
Authors: Kim Hyo‐Sin , Yi Nam‐Joon , Kim Jong Man , Hong Suk Kyun , Kwon Choon Hyuck David , Joh Jae‐Won , Lee Kwang‐Woong , Suh Kyung‐Suk 
Published: November 2018

BackgroundThe survival outcomes of recurrent hepatocellular carcinoma (HCC) after curative resection remain unclear due to lack of clear basis for the selection of treatment option. We investigated overall survival (OS) after intrahepatic recurrence and re‐recurrence free survival (rRFS) of the patients with recurrent HCC, and whether Milan criteria (MC) status at resection and recurrence impacts on OS and rRFS.MethodWe enrolled 959 patients who experienced recurrence after primary hepatic resection for HCC. We divided the cohort into four groups according to MC at two periods: IN‐rIN MC (HCC within MC at the time of resection‐recurrence within MC), IN‐rOUT MC (HCC within MC at the time of resection‐recurrence outside MC), OUT‐rIN MC (HCC outside MC at the time of resection‐recurrence within MC), and OUT‐rOUT MC (HCC outside MC at the time of resection‐recurrence outside MC).ResultsIn the entire cohort, 1‐, 3‐, and 5‐year OS after recurrence was 81.0%, 55.7%, and 45.8%, respectively, while rRFS was 63.7%, 46.1%, and 42.0%, respectively. The IN‐rIN MC group had the best outcomes (5‐year OS and rRFS, 54.5% and 45.7%, respectively). The IN‐rOUT and OUT‐rIN MC groups had better 5‐year OS outcomes than the OUT‐rOUT MC group (46.5%, 38.6%, and 24.8%, respectively; P < 0.05). However, 5‐year rRFS did not differ among the three groups (37.5%, 36.6%, and 31.9%, respectively; P > 0.05).ConclusionSurvival after first recurrence following curative primary resection for HCC was affected by MC at both time of resection and recurrence. Both the IN‐rOUT and OUT‐rIN MC groups with similar survival outcomes can be saved via curative treatment.
Key considerations prior to nasal high flow deployment in a Peruvian PICU from providers’ perspectives
Authors: Ellington Laura E. , Jacob‐Files Elizabeth , Becerra Rosario , Mallma Gabriela , Tantalean da Fieno José , Nielsen Katie R. 
Published: November 2018

AbstractAimImplementation of healthcare interventions in resource‐limited settings remains challenging. This exploratory qualitative study describes social and institutional factors to consider prior to nasal high flow deployment in a middle‐income country.MethodsResearchers conducted eight nursing focus groups and four semi‐structured physician interviews at Instituto Nacional de Salud del Niño in Lima, Peru. Participants were identified via purposive sampling. Data were transcribed, translated and coded using a rigorous and iterative process. Pertinent themes were identified using thematic analysis with Dedoose software.ResultsThirty‐nine nurses and four physicians participated in focus groups and interviews, respectively. Participants identified five major factors: (i) Adequate training, (ii) Clinician buy‐in, (iii) Resource‐limited setting, (iv) Local social context and (v) Organizational change management. To create buy‐in, physicians and nurses emphasised the need to recognise benefit of the intervention and agree with clinical practice standardization. Physicians and nurses described barriers specific to resource‐limited settings, including unreliable supply chain, whereas nurses shared concerns about increasing workload and physician–nurse social hierarchy. Participants recognised the importance of team commitment and ongoing interdisciplinary communication for sustainability.ConclusionWhile some factors to consider prior to deployment of healthcare technology are universal, resource‐limited settings have unique implementation barriers.
Patterns of changes in bipolar depressive symptoms revealed by trajectory analysis among 482 patients with bipolar disorder
Authors: Behrendt‐Møller Ida , Madsen Trine , Sørensen Holger Jelling , Sylvia Louisa , Friedman Edward S , Shelton Richard C , Bowden Charles L , Calabrese Joseph R , McElroy Susan L , Ketter Terence A , Reilly‐Harrington Noreen A , Gao Keming , Thase Michael , V Bobo William , Tohen Mauricio , McInnis Melvin , Kamali Masoud , Kocsis James H , Deckersbach Thilo , Köhler‐Forsberg Ole , Nierenberg Andrew A 
Published: November 2018

IntroductionDepressive episodes are often prevalent among patients with bipolar disorder, but little is known regarding the differential patterns of development over time. We aimed to determine and characterize trajectories of depressive symptoms among adults with bipolar disorder during 6 months of systematic treatment.MethodsThe pragmatic clinical trial, Bipolar Clinical Health Outcomes Initiative in Comparative Effectiveness (CHOICE), randomized 482 outpatients with bipolar disorder to lithium or quetiapine. Depressive symptoms were rated at up to 9 visits using the Montgomery‐Asberg Depression Rating Scale (MADRS). Growth mixture modeling was utilized to identify trajectories and multinomial regression analysis estimated associations with potential predictors.ResultsFour distinct trajectories of depressive symptoms were identified. The responding class (60.3%) with a rapid reduction and subsequent low level; the partial‐responding class (18.4%) with an initial reduction followed by an increase during the remaining weeks; the fluctuating class (11.6%) with a fluctuation in depressive symptoms; and the non‐responding class (9.7%) with sustained moderate‐severe depressive symptoms. Bipolar type I predicted membership of the non‐responding class and randomization to quetiapine predicted membership of either the responding or the non‐responding class.ConclusionApproximately 30% experienced a partial or fluctuating course, and almost 10% had a chronic course with moderate‐severe depression during 6 months. Patients diagnosed with bipolar type 1 had higher risk of being categorized into a class with a worse outcome. While no differences in average overall outcomes occurred between the lithium and quetiapine groups, trajectory analysis revealed that the lithium group had more variable courses.
The timing of salt structure growth in the Southern Permian Basin (Central Europe) and implications for basin dynamics
Authors: Warsitzka Michael , Jähne‐Klingberg Fabian , Kley Jonas , Kukowski Nina 
Published: November 2018

AbstractIn this paper, a literature‐based compilation of the timing and history of salt tectonics in the Southern Permian Basin (Central Europe) is presented. The tectono‐stratigraphic evolution of the Southern Permian Basin is influenced by salt movement and the structural development of various types of salt structures. The compilation presented here was used to characterize the following syndepositional growth stages of the salt structures: (a) “phase of initiation”; (b) phase of fastest growth (“main activity”); and (c) phase of burial’. We have also mapped the spatial pattern of potential mechanisms that triggered the initiation of salt structures over the area studied and summarized them for distinct regions (sub‐basins, platforms, etc.). The data base compiled and the set of maps produced from it provide a detailed overview of the spatial and temporal distribution of salt tectonic activity enabling the correlation of tectonic phases between specific regions of the entire Southern Permian Basin. Accordingly, salt movements were initiated in deeply subsided graben structures and fault zones during the Early and Middle Triassic. In these areas, salt structures reached their phase of main activity already during the Late Triassic or the Jurassic and were mostly buried during the Early Cretaceous. Salt structures in less subsided sub‐basins and platform regions of the Southern Permian Basin mostly started to grow during the Late Triassic. The subsequent phase of main activity of these salt structures took place from the Late Cretaceous to the Cenozoic. The analysis of the trigger mechanisms revealed that most salt structures were initiated by large‐offset normal faults in the sub‐salt basement in the large graben structures and minor normal faulting associated with thin‐skinned extension in the less subsided basin parts.
Thermal and exhumation histories of the northern subalpine chains (Bauges and Bornes—France): Evidence from forward thermal modeling coupling clay mineral diagenesis, organic maturity and carbonate clumped isotope (Δ47) data
Authors: Mangenot Xavier , Deçoninck Jean‐Francois , Bonifacie Magali , Rouchon Virgile , Collin Pierre‐Yves , Quesne Didier , Gasparrini Marta , Sizun Jean‐Pierre 
Published: November 2018

AbstractAssessing the thermal evolution of sedimentary basins over time is a major aspect of modern integrated basin analysis. While the behavior of clay minerals and organic matter with increasing burial is well documented in different geological and thermal settings, these methods are often limited by the temperature ranges over which they can be precisely applied and by the available material. Here, we explore the emergent Δ47 clumped isotope geospeedometry (based on the diffusional redistribution of carbon and oxygen isotopes in the carbonate lattice at elevated temperatures) to refine time‐temperature paths of carbonate rocks during their burial evolution. This study provides a reconstruction of the thermal and exhumation history of the Upper Cretaceous thrust belt series in the western subalpine massifs (Bauges and Bornes, French Alps) by a new approach combining for the first time available data from three independent geothermometers. The investigated area presents two zones affected by contrasting thermal histories. The most external zone has undergone a relatively mild thermal history (T < 70°C) and does not record any significant clay mineral diagenetic transformation. By contrast, the internal zone has experienced tectonic burial (prealpine nappes) in response to thrusting, resulting in overheating (T > 160–180°C) that induced widespread clay mineral diagenetic transformations (progressive illitization from R0 to R1 and R3 illite‐smectite mixed‐layers), organic matter maturation (oil window) and Δ47 thermal resetting with apparent equilibrium temperatures above 160°C. The three employed geothermal indicators conjointly reveal that the investigated Upper Cretaceous rocks have suffered a wide range of burial temperatures since their deposition, with a thermal maximum locally up to 160–180°C. High temperatures are associated with the tectonic emplacement of up to 4 km of prealpine nappes in the northern part of the studied area. Finally, a forward thermal modeling using Δ47, vitrinite reflectance and clay mineral data, is attempted to precisely refine the burial and exhumation histories of this area.
Donor liver apoptosis is associated with early allograft dysfunction and decreased short‐term graft survival after liver transplantation
Authors: Zhu Zebin , Tang Yunhua , Huang Shanzhou , Zhao Qiang , Schroder Paul M. , Zhang Zhiheng , Zhang Yixi , Sun Chengjun , Wang Linhe , Ju Weiqiang , Wang Dongping , Guo Zhiyong , He Xiaoshun 
Published: November 2018

AbstractBackgroundThe clinical significance of apoptosis in assessing the quality of donor liver grafts remains unknown.AimsThis study aimed to determine whether apoptosis in a donor liver is predictive of early allograft dysfunction (EAD) and graft survival after liver transplantation (LT).MethodsDonor liver specimens were analyzed for apoptosis using TUNEL assays. The prognostic factors for EAD were identified through logistic regression analyses, and a nomogram was developed.ResultsThe apoptosis index of donor livers in EAD patients was significantly higher than that of donors livers in non‐EAD patients (median 5.3; interquartile range [IQR] 3.4 vs 3.5; 3.6, P < 0.001). Multivariate analyses identified the apoptosis index of the donor liver (HR = 6.927, P < 0.001) and five other characteristics as independent predictors of EAD. A nomogram built on these predictive variables showed good calibration and discriminatory abilities, with a c‐index value of 0.847. The 30‐day graft survival rates in the high apoptosis index (apoptosis index >4.4%) group were significantly lower than those in the low apoptosis index (apoptosis index ≤4.4%) group (84.4% vs 97.6%, P = 0.004).ConclusionsDonor liver apoptosis plays a significant role in predicting EAD after LT. Furthermore, a high apoptosis index in the donor liver was associated with inferior graft survival in the short‐term.
FracKfinder: A MATLAB Toolbox for Computing Three‐Dimensional Hydraulic Conductivity Tensors for Fractured Porous Media
Authors: Young Nathan L. , Reber Jacqueline E. , Simpkins William W. 
Published: November 2018

AbstractFractures in porous media have been documented extensively. However, they are often omitted from groundwater flow and mass transport models due to a lack of data on fracture hydraulic properties and the computational burden of simulating fractures explicitly in large model domains. We present a MATLAB toolbox, FracKfinder, that automates HydroGeoSphere (HGS), a variably saturated, control volume finite‐element model, to simulate an ensemble of discrete fracture network (DFN) flow experiments on a single cubic model mesh containing a stochastically generated fracture network. Because DFN simulations in HGS can simulate flow in both a porous media and a fracture domain, this toolbox computes tensors for both the matrix and fractures of a porous medium. Each model in the ensemble represents a different orientation of the hydraulic gradient, thus minimizing the likelihood that a single hydraulic gradient orientation will dominate the tensor computation. Linear regression on matrices containing the computed three‐dimensional hydraulic conductivity (K) values from each rotation of the hydraulic gradient is used to compute the K tensors. This approach shows that the hydraulic behavior of fracture networks can be simulated where fracture hydraulic data are limited. Simulation of a bromide tracer experiment using K tensors computed with FracKfinder in HGS demonstrates good agreement with a previous large‐column, laboratory study. The toolbox provides a potential pathway to upscale groundwater flow and mass transport processes in fractured media to larger scales.
A Critical Analysis of Transverse Dispersivity Field Data
Authors: Zech Alraune , Attinger Sabine , Bellin Alberto , Cvetkovic Vladimir , Dietrich Peter , Fiori Aldo , Teutsch Georg , Dagan Gedeon 
Published: November 2018

AbstractTransverse dispersion, or tracer spreading orthogonal to the mean flow direction, which is relevant e.g, for quantifying bio‐degradation of contaminant plumes or mixing of reactive solutes, has been studied in the literature less than the longitudinal one. Inferring transverse dispersion coefficients from field experiments is a difficult and error‐prone task, requiring a spatial resolution of solute plumes which is not easily achievable in applications. In absence of field data, it is a questionable common practice to set transverse dispersivities as a fraction of the longitudinal one, with the ratio 1/10 being the most prevalent. We collected estimates of field‐scale transverse dispersivities from existing publications and explored possible scale relationships as guidance criteria for applications. Our investigation showed that a large number of estimates available in the literature are of low reliability and should be discarded from further analysis. The remaining reliable estimates are formation‐specific, span three orders of magnitude and do not show any clear scale‐dependence on the plume traveled distance. The ratios with the longitudinal dispersivity are also site specific and vary widely. The reliability of transverse dispersivities depends significantly on the type of field experiment and method of data analysis. In applications where transverse dispersion plays a significant role, inference of transverse dispersivities should be part of site characterization with the transverse dispersivity estimated as an independent parameter rather than related heuristically to longitudinal dispersivity.
Successful use of arterio‐venous graft for hemodialysis in patient with hemophilia
Authors: Amberker Deepa , Li Ting Ting , Rampure Ritesh 
Published: November 2018

AbstractHemodialysis (HD) is not the preferred approach for dialysis in patients with hemophilia. HD in such patients can possess a high risk of bleeding from arterio‐venous cannulation and hence peritoneal dialysis is the first choice in patients with hemophilia. The bleeding risk can be overcome by the prophylactic administration of factor VIII, which is a very costly solution. Here, we present a case of hemophilia with successful HD using an arterio‐venous graft averting the need for factor VIII. We review the literature on epidemiology and risk factors for chronic kidney disease in patients with hemophilia. We also discuss the dialysis and arterio‐venous graft options. In patients with hemophilia who are not candidates for peritoneal dialysis, tri‐layered arterio‐venous grafts offer distinct advantages.
Assessment of postoperative renal function after adrenalectomy in patients with primary aldosteronism
Authors: Onohara Tadashi , Takagi Toshio , Yoshida Kazuhiko , Iizuka Junpei , Okumi Masayoshi , Kondo Tsunenori , Ishida Hideki , Tanabe Kazunari 
Published: November 2018

ObjectiveTo investigate kidney function change during adrenalectomy in patients with primary aldosteronism and assess predictors of kidney function decline.MethodsThe present study included 90 patients who underwent adrenalectomy for primary aldosteronism between 2004 and 2017. Kidney function was evaluated 1 month after surgery. Predictors associated with a ≥10% decline in the estimated glomerular filtration rate were investigated. Kidney parenchymal volume was compared before and after surgery in 10 patients using volumetric studies.ResultsThe mean estimated glomerular filtration rate decline in the total cohort at 1 month after surgery was 13.3% (before: 72.9 mL/min/1.73 m2, after: 64.9 mL/min/1.73 m2, P < 0.0001). The mean serum plasma aldosterone concentration (before: 373 pg/mL vs after: 78 pg/mL, P < 0.0001) and potassium level (before: 3.7 mEq/L vs after: 3.9 mEq/L, P = 0.0001) were also significantly different after surgery. Age (odds ratio 6.37, P = 0.0006), preoperative plasma aldosterone concentration (odds ratio 3.12, P = 0.0209) and preoperative serum potassium level (odds ratio 2.87, P = 0.0010) were independent predictors of a ≥10% decline in estimated glomerular filtration rate. Volumetric studies in 10 patients showed that mean postoperative parenchymal volume was significantly decreased compared with the preoperative volume (263 cc vs 312 cc, P = 0.0003), with decreases in estimated glomerular filtration rate from 63 to 56 mL/min/1.73 m2 (P = 0.0146).ConclusionsKidney function deterioration after adrenalectomy can be detected in patients with primary aldosteronism. Age, preoperative plasma aldosterone concentration and preoperative potassium level are significant predictors of a decrease in the estimated glomerular filtration rate. Normal parenchymal volume decreases in line with renal functional deterioration.
Exploring the association between parental psychiatric disease and childhood atopic dermatitis: a matched case–control study
Authors: Hamann C.R. , Egeberg A. , Silverberg J.I. , Gislason G. , Skov L. , Thyssen J.P. 
Published: November 2018

AbstractBackgroundMaternal prenatal psychiatric disease has been identified as a possible risk factor for atopic dermatitis development in her children. We quantified the associations between maternal and paternal psychiatric disease and the development of atopic dermatitis in their offspring using nationwide registries.MethodsAll children in Denmark born between 1 January 1996 and 31 December 2011 who developed atopic dermatitis prior to their fifth birthday were identified and individually matched 1:10 with controls from the general population and with children receiving care in a similar ambulatory/hospital setting. Conditional logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals.ResultsA total of 8602 children with atopic dermatitis were matched with controls. Rates of parental psychiatric care were similar in the atopic dermatitis and control groups. When compared to the general population, weak associations were found between childhood atopic dermatitis and maternal history of depression [OR 1.18 (95% confidence interval: 1.12–1.26)], alcohol abuse [OR 1.37 (1.17–1.60)] and illicit drug use [OR 1.34 (1.14–1.60)]. However, associations became insignificant when the paediatric ambulatory/hospital control group was used [OR 1.05 (0.99–1.13)], [OR 1.14 (0.98–1.34)] and [OR 1.03 (0.88–1.22)], respectively. No paternal psychiatric disease or prenatal maternal psychiatric disease associated with the AD development in the offspring.ConclusionsWhile we found no consistent associations between maternal or paternal psychiatric disease and the subsequent development of atopic dermatitis in their offspring, children of parents with substance abuse issues may be more likely to receive an atopic dermatitis diagnosis.
Integrated cultural practices for whitefly management in organic tomato
Authors: Togni Pedro Henrique Brum , Marouelli Waldir Aparecido , Inoue‐Nagata Alice Kazuko , Pires Carmen Silvia Soares , Sujii Edison Ryoiti 
Published: November 2018

AbstractThe whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) is a serious pest among the diverse insect fauna of the tomato crop, especially when cultivated in organic systems. The feeding behaviour of B. tabaci is responsible for direct damage to tomato plants and for the transmission of several viruses, such as begomoviruses. The objective of this study was to evaluate the effect of integrating the cultural practices of intercropping and irrigation systems on B. tabaci abundance and the incidence of begomovirus in organic tomato systems. Field experiments were performed in the dry season for 2 years when B. tabaci abundance and begomovirus incidence were compared in tomato crops planted either in monoculture or intercropped with coriander and irrigated by overhead sprinklers or by a drip irrigation system. Tomato plants intercropped with coriander and irrigated by overhead sprinklers showed the lowest levels of B. tabaci colonization by adult and nymph densities. Most likely, the coriander plants produced visual and olfactory barriers for insect host plant selection, and the overhead sprinkler irrigation physically interfered with the movement and establishment of the insects. The combined effect of intercropping and sprinkler irrigation made tomato plants less suitable for B. tabaci establishment. Moreover, tomatoes intercropped with coriander and irrigated by sprinkler irrigation also reduced the incidence of begomovirus‐infected plants. In summary, integrating tomato–coriander intercropping and sprinkler irrigation can help manage B. tabaci and associated viruses in organic tomato crops.