bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relations between early maternal sensitivity and toddler self‐regulation: Exploring variation by oxytocin and dopamine D2 receptor genes
Authors: Augustine Mairin E. , Leerkes Esther M. , Smolen Andrew , Calkins Susan D. 
Published: June 2018

AbstractGene‐by‐environment interactions between maternal sensitivity during infancy and child oxytocin receptor gene (OXTR rs53576) and D2 dopamine receptor gene (DRD2 TaqIA, rs1822497) genotypes were explored as predictors of toddlers’ well‐regulated behavioral and physiological responses to maternal compliance demands. Maternal sensitivity was assessed across a range of mother–child interactions when children were 6 months and 1 year of age (N = 186), and toddler self‐regulatory responses were assessed through compliance and vagal withdrawal during a toy clean‐up task when children were 2 years of age. Sensitivity‐by‐OXTR interactions suggested two diathesis‐stress patterns, predicting compliance for the GG genotype group, and predicting physiological regulation for the AA/AG genotype group. A main effect for DRD2 genotype indicated that children with an A1 allele displayed less‐compliant behavior in toddlerhood. These results suggest that genetic differences may contribute to variation both in risk for self‐regulatory difficulties, and in relations between maternal sensitivity and children's responses to compliance demands at different levels of analysis.
Carbohydrate‐Appended TQNPEN [N,N,N′,N′‐Tetrakis(2‐quinolylmethyl)‐3‐aza‐1,5‐pentanediamine] Derivatives for Fluorescence Detection of Intracellular Cd2+
Authors: Mikata Yuji , Nozaki Kana , Kaneda Minori , Yasuda Keiko , Aoyama Masato , Tamotsu Satoshi , Matsumoto Arimasa 
Published: June 2018

AbstractInvited for the cover of this issue is the group of Yuji Mikata from Nara Women's University, Japan. The cover image shows the application of a carbohydrate‐appended polyquinoline ligand as a fluorescent sensor for intracellular Cd2+.
Impact of process conditions on the microbial community dynamics and metabolite production kinetics of teff sourdough fermentations under bakery and laboratory conditions
Authors: Harth Henning , Van Kerrebroeck Simon , De Vuyst Luc 
Published: June 2018

AbstractTeff and teff sourdoughs are promising ingredients for bread production. Therefore, this study aimed at the characterization of spontaneous and flour‐native starter culture‐initiated teff sourdough productions under bakery and laboratory conditions. Backslopped laboratory and bakery teff sourdough productions were characterized by different lactic acid bacteria (LAB) and yeast species, but were both characterized by a pH below 4.0 after five backslopping steps. The sourdough‐associated Lactobacillus sanfranciscensis was isolated for the first time from backslopped spontaneous teff sourdoughs. The autochthonous strain L. sanfranciscensis IMDO 150101 was tested as starter culture during laboratory teff sourdough fermentations. Its prevalence could be related to the process conditions applied, in particular the ambient temperature (below 30°C). Breads made with 20% teff sourdough (on flour basis) displayed interesting features compared with all‐wheat‐based reference breads. Teff sourdoughs were characterized as to their pH evolution, microbial community dynamics, and microbial species composition. Representative strains of the LAB species isolated from these sourdoughs, in particular L. sanfranciscensis, may be selected as starter cultures for the production of stable teff sourdoughs and flavorful breads, provided they are adapted to the environmental conditions applied.
Novel intra‐genic large deletions ofCTNNB1gene identified in WT desmoid‐type fibromatosis
Authors: Colombo Chiara , Urbini Milena , Astolfi Annalisa , Collini Paola , Indio Valentina , Belfiore Antonino , Paielli Nicholas , Perrone Federica , Tarantino Giuseppe , Palassini Elena , Fiore Marco , Pession Andrea , Stacchiotti Silvia , Pantaleo Maria Abbondanza , Gronchi Alessandro 
Published: June 2018

AbstractA wait and see approach for desmoid tumors (DT) has become part of the routine treatment strategy. However, predictive factors to select the risk of progressive disease are still lacking. A translational project was run in order to identify genomic signatures in patients enrolled within an Italian prospective observational study. Among 12 DT patients (10CTNNB1‐mutated and 2 wild type) enrolled from our institution only two patients (17%) showed a progressive disease. Tumor biopsies were collected for whole exome sequencing. Overall, DT exhibited low somatic sequence mutation rate and no additional recurrent mutation was found. In the two wild type (WT) cases, two novel alterations were detected: a complex deletion ofAPCand a pathogenic mutation ofLAMTOR2. Focusing on WT DT subtype, deep sequencing ofCTNNB1, APCandLAMTOR2was conducted on a retrospective series of 11 WT DT using a targeted approach. No other mutation ofLAMTOR2was detected, whileAPCwas mutated in two cases. Low‐frequency (mean reads of 16%)CTNNB1mutations were discovered in five samples (45%) and two novel intra‐genic deletions inCTNNB1were detected in two cases. Both deletions and low frequency mutations ofCTNNB1were highly expressed. In conclusion, a minority of DT is WT for eitherCTNNB1, APCor any other gene involved in the WNT pathway. In this subgroup novel and hard to be detected molecular alterations inAPCandCTNNB1were discovered, contributing to explain a portion of the allegedly WT DT cases.
Designing B‐ and T‐cell multi‐epitope based subunit vaccine using immunoinformatics approach to control Zika virus infection
Authors: Kumar Pandey Rajan , Ojha Rupal , Mishra Amit , Kumar Prajapati Vijay 
Published: June 2018

AbstractThe Zika virus is a rapidly spreading Aedes mosquito‐borne sickness, which creates an unanticipated linkage birth deformity and neurological turmoil. This study represents the use of the combinatorial immunoinformatics approach to develop a multiepitope subunit vaccine using the structural and nonstructural proteins of the Zika virus. The designed subunit vaccine consists of cytotoxic T‐lymphocyte and helper T‐lymphocyte epitopes accompanied by suitable adjuvant and linkers. The presence of humoral immune response specific B‐cell epitopes was also confirmed by B‐cell epitope mapping among vaccine protein. Further, the vaccine protein was characterized for its allergenicity, antigenicity, and physiochemical parameters and found to be safe and immunogenic. Molecular docking and molecular dynamics studies of the vaccine protein with the toll‐like receptor‐3 were performed to ensure the binding affinity and stability of their complex. Finally, in silico cloning was performed for the effective expression of vaccine construct in the microbial system (Escherichia coli K12 strain). Aforementioned approaches result in the multiepitope subunit vaccine which may have the ability to induce cellular as well as humoral immune response. Moreover, this study needs the experimental validation to prove the immunogenic and protective behavior of the developed subunit vaccine.
Enhancing group cognitive‐behavioral therapy for hoarding disorder with between‐session Internet‐based clinician support: A feasibility study
Authors: Ivanov Volen Z. , Enander Jesper , Mataix‐Cols David , Serlachius Eva , Månsson Kristoffer N.T. , Andersson Gerhard , Flygare Oskar , Tolin David , Rück Christian 
Published: June 2018

AbstractObjectiveHoarding disorder (HD) is difficult to treat. In an effort to increase efficacy and engagement in cognitive‐behavioral therapy (CBT), we developed and evaluated a novel intervention comprising group CBT combined with between‐session Internet‐based clinician support for people with HD.MethodTwenty participants with HD received group CBT combined with an Internet‐support system enabling therapist–participant communication between group sessions.ResultsThe treatment was associated with a significant reduction on the Saving Inventory—Revised (SI‐R) and a large effect size (Cohen's d = 1.57) was found at posttreatment. Treatment gains were maintained at the 3‐month follow‐up. Group attendance was high and no participants dropped out from treatment prematurely. Between‐session motivational support from the therapist was most frequently mentioned as the main strength of the system.ConclusionThe results of this study support adding Internet‐based clinician support to group CBT for HD to increase treatment adherence and, potentially, improve the overall efficacy of CBT.
Exposure‐Response Modeling Analyses for Sirukumab, a Human Monoclonal Antibody Targeting Interleukin 6, in Patients With Moderately to Severely Active Rheumatoid Arthritis
Authors: Xu Yan , Hu Chuanpu , Zhuang Yanli , Hsu Benjamin , Xu Zhenhua , Sharma Amarnath , Zhou Honghui 
Published: June 2018

AbstractTo characterize the dose‐exposure–response relationship of sirukumab, an anti–interleukin 6 human monoclonal antibody, in the treatment of moderately to severely active rheumatoid arthritis (RA), we conducted exposure‐response (E‐R) modeling analyses based on data from two pivotal phase 3 placebo‐controlled trials of sirukumab in patients with RA who were inadequate responders to nonbiologic disease‐modifying antirheumatic drugs or anti‐tumor necrosis factor α agents. A total of 2176 patients were included for the analyses and received subcutaneous administration of either placebo or sirukumab 50 mg every 4 weeks or 100 mg every 2 weeks. The clinical endpoints were 20%, 50%, and 70% improvement in the American College of Rheumatology response criteria (ie, ACR20, ACR50, and ACR70), and 28‐joint Disease Activity Index Score (DAS28) using C‐reactive protein. To provide a thorough assessment of the sirukumab E‐R relationship, 2 pharmacokinetic/pharmacodynamic modeling approaches were implemented, including joint longitudinal modeling (ie, indirect response modeling of the time course of the 2 clinical endpoints) and landmark analyses (ie, direct linking of selected pharmacokinetic parameters to response at week 16 or 24). Results from both modeling analyses were generally consistent, and collectively suggested that the sirukumab subcutaneous dose of 50 mg every 4 weeks would produce near‐maximal efficacy. No covariates identified in the E‐R modeling analyses would have a significant impact on dose‐response. Despite body weight and comorbid diabetes having significant effect on sirukumab exposure, simulations suggested that their effect on efficacy was small. Our work provides a comprehensive evaluation of sirukumab E‐R to support dose recommendations in patients with RA.
Design, Synthesis, and In Vitro Antibacterial Activities of Propylene‐tethered Gatifloxacin‐isatin Hybrids
Authors: Guo Hua 
Published: June 2018

A series of novel mono‐/bis‐isatin‐gatifloxacin hybrids 3a–f and 4a–f tethered through propylene were designed, synthesized, and evaluated for their in vitro antibacterial activities against representative Gram‐positive and Gram‐negative pathogens. The results indicated that all mono‐isatin‐gatifloxacin hybrids exhibited considerable antibacterial activities with minimum inhibitory concentration ranging from 0.06 to 4 μg/mL against the majority of the tested strains. In particular, the mono‐isatin‐gatifloxacin hybrid 3b was found as potent as the parent gatifloxacin against Gram‐positive organisms and could act as a starting point for further optimization.
Efficient Generation of Microwave Plasmonic Vortices via a Single Deep‐Subwavelength Meta‐Particle
Authors: Su Hai , Shen Xiaopeng , Su Guangxu , Li Lin , Ding Jianping , Liu Fanxin , Zhan Peng , Liu Yongmin , Wang Zhenlin 
Published: June 2018

AbstractLight beams carrying orbital angular momentum (OAM) in the form of optical vortices have attracted great interest due to their capability for providing a new dimension and approach to manipulate light–matter interactions. Recently, plasmonics has offered efficient ways to focus vortex beams beyond the diffraction limit. However, unlike in the visible and near‐infrared regime, it is still a big challenge to realize plasmonic vortices at far‐infrared and even longer wavelengths. An effective strategy to create deep‐subwavelength near‐field electromagnetic (EM) vortices operating in the low frequency region is proposed. Taking advantage of the asymmetric spatial distribution of EM field supported by a metallic comb‐shaped waveguide, plasmonic vortex modes that are strongly confined in a well‐designed deep‐subwavelength meta‐particle with desired topological charges can be excited. Such unique phenomena are confirmed by the microwave experiments. An equivalent physical model backed up by the numerical simulations is performed to reveal the underlying mechanism of the plasmonic vortex generation. This spoof‐plasmon assisted focusing of EM waves with OAM may find potentials for functional integrated elements and devices operating in the microwave, terahertz, and even far‐infrared regions.
Thermoresponsive Polyurethane Bearing Oligo(Ethylene Glycol) as Side Chain Without Polyol at Polymer Backbone Achieved Excellent Hydrophilic and Hydrophobic Switching
Authors: Aoki Daisuke , Ajiro Hiroharu 
Published: June 2018

AbstractIn order to prepare thermoresponsive polyurethane gels, a novel polyurethane bearing oligo(ethylene glycol) (OEG) as the side chain is successfully synthesized with hexamethylene diisocyanate and OEG tartrate ester. The aqueous solution of the polyurethane shows sharp and clear lower critical solution temperature behavior at 34 °C. Furthermore, a hydrogel based on the same polyurethane is also successfully prepared using glycerol as the crosslinker. This polyurethane hydrogel including 10 mol% of glycerol presents a large swelling ratio change between 4 °C and 37 °C from 250% to 40%.
Light‐Induced RAFT Single Unit Monomer Insertion in Aqueous Solution—Toward Sequence‐Controlled Polymers
Authors: Aerts Annelore , Lewis Reece W. , Zhou Yanyan , Malic Nino , Moad Graeme , Postma Almar 
Published: June 2018

AbstractFirst report on the sequential, visible light‐initiated, single unit monomer insertion (SUMI) of N,N‐dimethylacrylamide (DMAm) into the reversible addition fragmentation chain transfer (RAFT) agent, 4‐((((2‐carboxyethyl)thio)carbonothioyl)thio)‐4‐cyanopentanoic acid (CTA1), in aqueous solution is provided. The specificity for SUMI over formation of higher oligomers and/or RAFT agent‐derived by‐products is higher for longer irradiation wavelengths. Red light provides the cleanest product (selective SUMI), showing a linear pseudo‐first order kinetic profile to high (>80%) conversion, but also the slowest reaction rate. Blue light provides a relatively rapid reaction, but also gives some by‐products (<2%) and the kinetic profile displays a conversion plateau at >65% conversion. Higher specificity with red light is attributed to CTA1 absorbing at longer wavelengths than the SUMI product, which allows selective excitation of CTA1. The use of a higher reaction temperature (65 °C vs ambient) results in a higher reaction rate and a reduction in oligomer formation.
Orofacial strength, dysarthria, and dysphagia in congenital myotonic dystrophy
Authors: Berggren Kiera N. , Hung Man , Dixon Melissa M. , Bounsanga Jerry , Crockett Becky , Foye Mary D. , Gu Yushan , Campbell Craig , Butterfield Russell J. , Johnson Nicholas E. 
Published: June 2018

ABSTRACTIntroduction: Herein we present an exploratory study of orofacial function in children with congenital myotonic dystrophy (CDM) vs. healthy controls. Methods: We evaluated 41 children with CDM and 29 healthy controls for speech and swallow function and for lingual and labial strength. Results: The Iowa Oral Performance Instrument (IOPI), measuring tongue strength, and a lip force meter (LFM), measuring lip strength, had excellent interrater reliability with intraclass correlation coefficients (ICCs) of 0.75 (n = 19, P < 0.001) and 0.96 (n = 20, P < 0.001), respectively. Mean overall lingual strength was 3.5‐fold less and labial strength was about 7‐fold less in CDM patients than in healthy controls. Eighteen of 24 children with CDM demonstrated dysarthria and an additional 11 participants were nonverbal. Dysarthria correlated moderately with lingual strength, age, and dysphagia. Strength measures correlated moderately with dysphagia. Discussion: Children with CDM have impaired orofacial functioning that affects communication and swallowing. Reliability of strength measures may be useful for future therapeutic trials. Muscle Nerve 58: 413–417, 2018
Combining remote sensing with physical flow laws to estimate river channel geometry
Authors: Harada Sho , Li S. Samuel 
Published: June 2018

AbstractA reliable representation of river terrains is essential to river research. Field surveys of river channel geometry are time‐consuming, costly, and logistically constrained and thus would encounter difficulties to achieve sufficient spatial coverage, resolution, and frequency of resurvey. This paper aims to demonstrate an efficient approach to building a river terrain model (RTM), the emphasis being on how to combine bathymetry and topography derived from satellite images captured at different flow stages. A method for calculating the difference between high and low stages (DHLS) based on the uniform‐flow theory is proposed. Calculations are carried out for a 13‐km long meandering section of the gravel‐bed Goulais River in Canada, which features pools and riffles, alternating point bars, and midchannel bars. A RTM for this complex section has been successfully produced. It consists of three data components: bathymetry at low stage, topography at high stage, and DHLS. The results capture realistic characteristics, including thalweg shift, steep outer banks, and gradual inner banks. They also show realistic longitudinal and lateral locations of pools and riffles. To illustrate potential applications of RTM, this paper has computed extreme bed shear stresses at bankfull discharge through hydrodynamics simulations of depth‐averaged flow in the river section and further estimated bed‐sediment grain‐size distributions. The estimates compare well with field measurements. The DHLS can vary significantly along a river channel. The proposed method for determining it is not site‐specific, and hence applicable to other rivers. The novelty of the methodology discussed lies in combining remote sensing techniques with physical flow laws.
CuO Nanoparticles as An Efficient Heterogeneous Catalyst for the 1,3‐Dipolar Cycloaddition of Dicarbonyl Compounds to Azides
Authors: da S. Dias Cássio , de M. Lima Thiago , Lima Carolina G. S. , Zuekrman‐Schpector Julio , Schwab Ricardo S. 
Published: June 2018

AbstractSubstituted 1,2,3‐triazoles are important heterocyclic molecules with applications in diverse research areas. The organocatalytic (3+2) cycloaddition reaction of azides with active methylene compounds has proven to be a powerful strategy for the synthesis of a variety of 1,2,3‐triazoles with different substituents. However the reported methods in the literature, commonly used a homogenous organocatalyst. Considering this point, here we have reported a novel heterogeneous protocol for the synthesis of 1,4,5‐trisubstituted 1,2,3‐triazoles by reaction of different dicarbonyl compounds with aryl azides catalyzed by copper oxide nanoparticles under microwave irradiation. The important features of this methodology are high yield products, short reaction times and recyclability of the CuO catalyst.
Effects of workload on teachers' functioning: A moderated mediation model including sleeping problems and overcommitment
Authors: Huyghebaert Tiphaine , Gillet Nicolas , Beltou Nicolas , Tellier Fanny , Fouquereau Evelyne 
Published: June 2018

AbstractThis study investigated the mediating role of sleeping problems in the relationship between workload and outcomes (emotional exhaustion, presenteeism, job satisfaction, and performance), and overcommitment was examined as a moderator in the relationship between workload and sleeping problems. We conducted an empirical study using a sample of 884 teachers. Consistent with our predictions, results revealed that the positive indirect effects of workload on emotional exhaustion and presenteeism, and the negative indirect effects of workload on job satisfaction and performance, through sleeping problems, were only significant among overcommitted teachers. Workload and overcommitment were also directly related to all four outcomes, precisely, they both positively related to emotional exhaustion and presenteeism and negatively related to job satisfaction and performance. Theoretical contributions and perspectives and implications for practice are discussed.
Prevalence, antenatal management and perinatal outcome of monochorionic monoamniotic twin pregnancy: a collaborative multicenter study in England, 2000–2013
Authors: Glinianaia S. V. , Rankin J. , Khalil A. , Binder J. , Waring G. , Sturgiss S. N. , Thilaganathan B. , Hannon T. 
Published: June 2018

ABSTRACTObjectivesTo determine the prevalence of monochorionic monoamniotic (MCMA) twin pregnancy and to describe perinatal outcome and clinical management of these pregnancies.MethodsIn this multicenter cohort study, the prevalence of MCMA twinning was estimated using population‐based data on MCMA twin pregnancies, collected between 2000 and 2013 from 11 Northern Survey of Twin and Multiple Pregnancy (NorSTAMP) maternity units. Pregnancy outcome at < 24 weeks' gestation, antenatal parameters and perinatal outcome (from ≥ 24 weeks to the first 28 days of age) were analyzed using combined data on pregnancies confirmed to be MCMA from NorSTAMP and the Southwest Thames Region of London Obstetric Research Collaborative (STORK) multiple pregnancy cohort for 2000–2013.ResultsThe estimated total prevalence of MCMA twin pregnancies in the North of England region was 8.2 per 1000 twin pregnancies (59/7170), and the birth prevalence was 0.08 per 1000 pregnancies overall (singleton and multiple). Using combined data from NorSTAMP and STORK, the rate of fetal death (at < 24 weeks' gestation), including terminations of pregnancy and selective feticide, was 31.8% (54/170); the overall perinatal mortality rate was 14.7% (17/116), ranging from 69.2% at < 30 weeks to 4.5% at ≥ 33 weeks' gestation. MCMA twins that survived in utero beyond 24 weeks were delivered, usually by Cesarean section, at a median of 33 (interquartile range, 32–34) weeks of gestation.ConclusionsIn MCMA twins surviving beyond 24 weeks of gestation, there was a higher survival rate compared with in previous decades, presumably due to early diagnosis, close surveillance and elective birth around 32–34 weeks of gestation. High perinatal mortality at early gestations was attributed mainly to extreme prematurity due to preterm spontaneous labor. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.