bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly
Authors: Zhang Xiaoyan , Brachner Andreas , Kukolj Eva , Slade Dea , Wang Yanzhuang 
Published: October 2019

ABSTRACT
Sirtuin 2 (SIRT2) is an NAD-dependent sirtuin deacetylase that regulates microtubule and chromatin dynamics, gene expression and cell cycle progression, as well as nuclear envelope reassembly. Recent proteomic analyses have identified Golgi proteins as SIRT2 interactors, indicating that SIRT2 may also play a role in Golgi structure formation. Here, we show that SIRT2 depletion causes Golgi fragmentation and impairs Golgi reassembly at the end of mitosis. SIRT2 interacts with the Golgi reassembly stacking protein GRASP55 (also known as GORASP2) in mitosis when GRASP55 is highly acetylated on K50. Expression of wild-type and the K50R acetylation-deficient mutant of GRASP55, but not the K50Q acetylation-mimetic mutant, in GRASP55 and GRASP65 (also known as GORASP1) double-knockout cells, rescued the Golgi structure and post-mitotic Golgi reassembly. Acetylation-deficient GRASP55 exhibited a higher self-interaction efficiency, a property required for Golgi structure formation. These results demonstrate that SIRT2 regulates Golgi structure by modulating GRASP55 acetylation levels.
Use of radiobiology in medical jurisprudence, with particular reference to delays in diagnosis and therapeutic onset
Authors: Jones Bleddyn 
Published: October 2019

Objective:
This paper considers aspects of radiobiology and cell and tissue kinetics applicable to legal disputations concerned with diagnostic and treatment onset delays.

Methods:
Various models for tumour volume changes with time are reviewed for estimating volume ranges at earlier times, using ranges of kinetic parameters. Statistical cure probability methods, using Poisson statistics with allowances for parameter heterogeneity, are also described to estimate the significance of treatment delays, as well as biological effective dose (BED) estimations of radiation effectiveness.

Results:
The use of growth curves, based on parameters in the literature but with extended ranges, can identify a window of earlier times when such tumour volumes would be amenable to a cure based on the literature for curability with stage (and dimensions). Also, where tumour dimensions are not available in a post-operative setting, higher cure probabilities can be achieved if treatment had been given at earlier times.

Conclusion:
The use of radiobiological modelling can provide useful insights, with quantitative assessments of probable prior conditions and future outcomes, and thus be of assistance to a Court in deciding the most correct judgement.

Advances in knowledge:
This study collates prior knowledge about aspects of radiobiology that can be useful in the accumulation of sufficient proof within medicolegal claims involving diagnostic and treatment days.
The BACH classification of long bone osteomyelitis
Authors: Hotchen Andrew J. , Dudareva Maria , Ferguson Jamie Y. , Sendi Parham , McNally Martin A. 
Published: October 2019

Objectives The aim of this study was to assess the clinical application of, and optimize the variables used in, the BACH classification of long-bone osteomyelitis. Methods A total of 30 clinicians from a variety of specialities classified 20 anonymized cases of long-bone osteomyelitis using BACH. Cases were derived from patients who presented to specialist centres in the United Kingdom between October 2016 and April 2017. Accuracy and Fleiss’ kappa (Fκ) were calculated for each variable. Bone involvement (B-variable) was assessed further by nine clinicians who classified ten additional cases of long bone osteomyelitis using a 3D clinical imaging package. Thresholds for defining multidrug-resistant (MDR) isolates were optimized using results from a further analysis of 253 long bone osteomyelitis cases. Results The B-variable had a classification accuracy of 77.0%, which improved to 95.7% when using a 3D clinical imaging package (p < 0.01). The A-variable demonstrated difficulty in the accuracy of classification for increasingly resistant isolates (A1 (non-resistant), 94.4%; A2 (MDR), 46.7%; A3 (extensively or pan-drug-resistant), 10.0%). Further analysis demonstrated that isolates with four or more resistant test results or less than 80% sensitive susceptibility test results had a 98.1% (95% confidence interval (CI) 96.6 to 99.6) and 98.8% (95% CI 98.1 to 100.0) correlation with MDR status, respectively. The coverage of the soft tissues (C-variable) and the host status (H-variable) both had a substantial agreement between users and a classification accuracy of 92.5% and 91.2%, respectively. Conclusions The BACH classification system can be applied accurately by users with a variety of clinical backgrounds. Accuracy of B-classification was improved using 3D imaging. The use of the A-variable has been optimized based on susceptibility testing results. Cite this article: A. J. Hotchen, M. Dudareva, J. Y. Ferguson, P. Sendi, M. A. McNally. The BACH classification of long bone osteomyelitis. Bone Joint Res 2019;8:459–468. DOI: 10.1302/2046-3758.810.BJR-2019-0050.R1
Risk assessment of antibiotic resistance development by antibiotic-loaded bone cements: is it a clinical concern?
Authors: Berberich Christof , Sanz-Ruiz Pablo 
Published: October 2019

Because of the risk of bacterial biofilm infections, prophylactic use of antibiotics in orthopaedic procedures involving the implantation of large prosthesis systems is considered mandatory. A strategy based on the rationale that local antibiotics released from bone cement or other carriers establish a second antibacterial frontline in and around the prosthesis is considered complementary to the administration of systemic antibiotics. Although less common as a consequence of the initially very high drug concentrations of local antibiotics in the tissues, a selection process of previous high resistance bacteria may occur, leading to antibiotic resistance. The use of antibiotic combinations in bone cement is generally accepted to improve antibiotic efficacy and minimizes the treatment failure risk due to antibiotic resistance. This is important in septic revisions and/or in patients at particularly high risk of infection. On an individual basis, the benefit of a lower infection probability with combined systemic and local antibiotic application should outweigh the risk of the selection of more resistant bacteria. Each prevented infection means that a complex and extended antibiotic therapy with risk of resistance development over time has been avoided. On an epidemiological level there is no clinical evidence that the routine use of bone cement impregnated with appropriate bactericidal antibiotics promotes the widespread development of antibiotic resistance and thereby puts the successful treatment of a prosthetic joint infection at higher risk.Cite this article: EFORT Open Rev 2019;4:576-584. DOI: 10.1302/2058-5241.4.180104
Danser l'architecture
Authors: Lheureux Charlotte 
Published: October 2019

L’article fait suite au séminaire "Architecture & Art", qui invitait des étudiants en danse et en architecture à représenter, par le corps et par le mouvement, une promenade architecturale effectuée préalablement au sein d’édifices iconiques. Le propos consiste ici à interroger les processus de création des deux disciplines, en utilisant notamment l’écriture comme trait d’union.
Citation de l'article
A venir
Bibliographie
A venir
Privacy-preserving verifiable delegation of polynomial and matrix functions
Authors: Zhang Liang Feng , Safavi-Naini Reihaneh 
Published: October 2019

AbstractOutsourcing computation has gained significant popularity in recent years due to the development of cloud computing and mobile services. In a basic outsourcing model, a client delegates computation of a function f on an input x to a server. There are two main security requirements in this setting: guaranteeing the server performs the computation correctly, and protecting the client’s input (and hence the function value) from the server. The verifiable computation model of Gennaro, Gentry and Parno achieves the above requirements, but the resulting schemes lack efficiency. This is due to the use of computationally expensive primitives such as fully homomorphic encryption (FHE) and garbled circuits, and the need to represent f as a Boolean circuit. Also, the security model does not allow verification queries, which implies the server cannot learn if the client accepts the computation result. This is a weak security model that does not match many real life scenarios. In this paper, we construct efficient (i.e., without using FHE, garbled circuits and Boolean circuit representations) verifiable computation schemes that provide privacy for the client’s input, and prove their security in a strong model that allows verification queries. We first propose a transformation that provides input privacy for a number of existing schemes for verifiable delegation of multivariate polynomial f over a finite field. Our transformation is based on noisy encoding of x and keeps x semantically secure under the noisy curve reconstruction (CR) assumption. We then propose a construction for verifiable delegation of matrix-vector multiplication, where the delegated function f is a matrix and the input to the function is a vector. The scheme uses PRFs with amortized closed-form efficiency and achieves high efficiency. We outline applications of our results to outsourced two-party protocols.
Crystal structure of iodido-triphenyl-(triphenylphosphine oxide)tin(IV), C36H30IOPSn
Authors: Lo Kong Mun , Lee See Mun , Tiekink Edward R.T. 
Published: October 2019

Abstract
C36H30IOPSn, monoclinic, P21 (no. 4), a = 9.7251(6) Å, b = 17.3609(11) Å, c = 10.0542(6) Å, β = 114.379(1)°, V = 1546.16(17) Å3, Z = 2, R
gt(F) = 0.0113, wR
ref(F
2) = 0.0301, T = 296(2) K.
Promoting botanical literacy with a mobile application - CampusFlora - using an interdisciplinary, student-as-partners approach
Authors: Dimon Richard , Pettit Lachlan , Cheung Caroline , Quinnell Rosanne 
Published: October 2019

In this article, we describe our students-as-partners process for bringing undergraduate and academic staff together to develop a mobile application (app) - CampusFlora - for use across our campuses. Our project at the University of Sydney, Australia, was conceived as a way to improve the botanical literacy of biology students by engaging undergraduates to develop online maps of plant locations coupled with information relevant to biology curriculum. Through continuous improvements to the CampusFlora app system, we have expanded the user-base well beyond the life science student cohorts and now offer content that embraces cultural competence and organisational health initiatives. We offer reflections from student and staff partners on the project that highlight the value of the students-as-partners approach, and the potential value of establishing student partnerships across disciplines, across institutions, and into the community at large.
RESTRICTIONS TO THE RIGHT OF PROPERTY: CONSTITUTIONAL VERSIONS IN THE POST-SOVIET COUNTRIES
Authors: A. Sushkov Pavel , V. Markhgeym Marina , E. Genzyuk Eduard , E. Novikova Alevtina , E. Tonkov Evgeniy 
Published: October 2019

Purpose: The paper deals with constitutional approaches to the formalization of restrictions and deprivation of property rights in 12 post-Soviet countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan, and Ukraine.
Methodology: As an analysis of specific constitutional approaches to the restriction of property rights, the paper pays attention to the conditions for the admissibility of its deprivation, compensated withdrawal and alienation of property as an object of property rights.
Applications: This research can be used for universities, teachers, and students.
Results: Based on the analysis, it was concluded that legal forms of restriction of the right to property are set forth in direct and indirect versions. The first reflects the direct wording of the permissibility of restricting the right to property; the second is due to the general rules of constitutional restriction of the rights of a person and citizen.
Entre lo posible y lo imposible: los proyectos topográficos geodésicos de la Argentina (1912-1950)
Authors: Mazzitelli Mastricchio Malena 
Published: October 2019

Desde 1912, el Instituto Geográfico Militar (IGM) propuso un plan cartográfico nacional que implicaba mediciones geodésicas, tanto de tipo altimétrico como para la medición de las coordenadas geográficas. El proyecto se consideraba superador respecto de otra clase de mediciones existentes. Sin embargo, el plan del IGM fue muy ambicioso y, a pesar de haber sido readaptado en varias oportunidades, hubo que esperar hasta fines de la década de 1940 para cumplir con los propósitos. El objetivo de este trabajo es reconstruir las prácticas desplegadas por la institución para desarrollar dicho plan. Para ello, se usaron las publicaciones realizadas por el IGM en el momento en que se presentaron los planes cartográficos. El análisis permitió concluir que los proyectos superaban no solo las expectativas, sino también las posibilidades técnicas con las que contaba el país para realizar esa clase de mediciones.
entina.
LEADERSHIP STYLE, DISCIPLINE, MOTIVATION AND THE IMPLICATIONS ON TEACHERSâ€™PERFORMANCE
Authors: Ratnasih Cicih 
Published: October 2019

This study aims to determine the effect of leadership style, discipline, motivation and performance either partially or simultaneously in East Jakarta area.This study is using quantitative method. Total population in the human resource development as the study sample counted as many as 112 respondents. The sampling technique is using purposive sampling.The variables in this study areindependent variable, consist of leadership style, discipline, motivation and performance, and the dependent variable consist. Tests proved that motivation has a positive influence on the performance of teachers. Looking at the calculationsthat have been done the coefficient values obtained is 0.416 and t-count value is 5.984 with a significance level of 0.000 which less than 0.05, means that this hypothesis accepts Ha and reject Ho, Tests proved that the style of leadership have a positive impact on teacher performance. Judging from the calculations that have been done obtained coefficient value of 0.421 and t-count value of6.446 with a significance value of 0.000, smaller than 0.05. Thus, Ha is accepted and Ho is rejected., The tests proved that the discipline of work has a positive influence on the performance of teachers. Judging from the calculations that has been done obtained coefficient value of 0.151 and the t-count value of 2.055 with a significance level of 0,042 which smaller than 0.05, means that the hypothesis in this research reject Ho and accept Ha. The results showed that the leadership style, discipline, and motivation partially have significant effect on performance ofaudit quality in East Jakarta area.Leadership style, discipline, motivationsimultaneously have significant effect on performance with coefficient of determination 81.6%.
Keywords: Leadership Style, Discipline, Motivation, Teacher Performance
EFFECT OF LEARNING CULTURE, EMPOWERMENT, AND CYBER SKILL COMPETENCY ON SELF-ENGAGEMENT EMPLOYEES
Authors: Permata Sari S.R.M. Indah 
Published: October 2019

The purpose of this research is to comprehensively about the effect of learning culture, empowerment, and cyber skill competence on self engagement of the employee in Directorate General of Potential for Defense Ministry of Defence Republic of Indonesia. The research methodology was survey with path analysis applied in testing hypothesis. It was conducted to 150 employees from population 241 employee who was selected in simple random way.Analysis and interpretation of data indicate that (1) learning culture has a positive direct effect in self engagement, (2) empowerment has a positive direct effect in self engagement, (3) cyber skill competence has a positive direct effect in self engagement, (4) learning culture has a positive direct effect in cyber skill competence, (5) empowerment has a positive direct effect in cyber skill competence, and (6) learning culture has a positive direct effect in empowerment
Keywords: Learning Culture, Empowerment, Cyber Skill Competency, Self Engagement.
INFLUENCE OF ORGANIZATIONAL CULTURE, TEAM CONDUCTIVITY, PERSONALITY, AND TRUST TO THE OUTLET LEADING ORGANIZATION COMMITMENT
Authors: Sutan Ardani Dedi 
Published: October 2019

The purpose of this study was to Determine the effect of organizational culture, cohevision team, persoanlity, and trust of organizational commitment outlet leader in Bank Negara Indonesia, Regional offices, Senayan Jakarta. This research tried to answer problems about the organizational comitment with increasing evidence of service employee. The research was conducted on organizational commitment involving of 98 outlet leader had been selected from a target Populations of 130 outlet leader by using the quantitative approach with path analysis methods. The research of hypothesis testing show: (1) organizational culture had a direct positive effect on organizational commitment; (2) personality had a direct positive effect on organizational commitment; (3) trust had a direct positive effect on organizational commitment; (4) organizational culture had a direct positive effect on trust: (5) cohevision team had a direct positive effect on trust: (6) personality had a direct positive effect on trust: (7) organizational culture had a direct positive effect on cohevision team (8) personality had a direct positive effect on cohevision team: Therefore to improve the organizational commitment of outlet leader in Bank Negara Indonesia, Regional Offices Senayan Jakarta. Need to increase is organizational culture, cohevision team, personality and trust.
Keywords:Organzational Culture, Cohevision Team, Personality, Trust, OrganizationalCommitment.
EVALUATION OF MICRO, SMALL AND MEDIUM ENTERPRISES DEVELOPMENT PROGRAM IN PT FREEPORT INDONESIA
Authors: Oktavia Theresia 
Published: October 2019

This research is aimed to evaluate the implementation of Micro, Small and medium enterprise development Program in PT Freeport Indonesia. The method used for this research was qualitative descriptive, using CIPP (Context, Input, Process, and Product) evaluation model. Primary data was obtain through interviews and observation, and secondary data document study. The results showed that Program Context, Input and process were classified as high category, while outcomes as moderate categories. The overall evaluation shows Moderate categories.The Program was rendered effective to achieve the goal of enhancing the Micro, Small and Medium enterprise Development.It should be continued and further enhanced by the management to acquire better enterprise graduates.Keywords: Evaluation of Program, Micro, small and medium enterprise, PT Freeport Indonesia
THE EVALUATION OF EDUCATION PROGRAM IMPLEMENTATION ON HEAD OF INDONESIAN REPUBLIC BANK UNIT
Authors: Y. Afrizal , Sujanto Bedjo , Akbar Makruf 
Published: October 2019

This study aims to evaluate education programs head of Indonesia Republic Bank (BRI) Unit head in Pekanbari Regional Office at BRI Corporate University Padang. The study conducted for six months (October 2015 up to March 2016) using CIPP evaluation model. The results showed that educational programs of head of BRI Unitis already well underway in accordance with the educational programs that have been compiled. Nevertheless, it is necessary to evaluate on the improvement of the competence of the Head of BRI in the workplace after attending the educational process and the impact of education programs to the banking business. Recommendations are given for the improvement of the education programs is to revise the Instructional Systems Design so that the effectiveness of the educational program after participants return to their bases can be evaluated.
Keywords: Evaluation, CIPP Model, Educational Program, Bank BRI
THE EFFECT TRANSFORMATIONAL LEADERSHIP, PERSONALITY AND JOB PERFORMANCE ADMINISTRATION EMPLOYEE
Authors: Andinasari Andinasari , Sujanto Bedjo , Mukhtar Mukhneri 
Published: October 2019

The purpose of this study was determine the effect transformational leadership, personality and job performance administration employeeUniversity of Indonesian Teachers Union of Palembang (PGRI). This research try answer problems about job performance involving of 144 administration employee had been selected from the target population of 223 employee by using quantitative approach with path analysis methods. The reseach of conclude show (1) transformational leadership had a direct effect positif on job performance; (2) Personality had a direct effect positif. Therefore to improve the job performance administration employee PGRI University of Palembang.
Keywords:Transformational Leadership, Personality, Job Performance.
EVALUATION OF EDUCATION IMPLEMENTATION OF TRAINING PIM III IN AGENCY OF HUMAN RESOURCE DEVELOPMENT
Authors: Sari Kencana , Mukhtar Mukneri , Supriyati Yetti 
Published: October 2019

This study is a qualitative research aims to find out how the implementation of leadership level III training at Human Resources Development Board of Province of South Sumatera based on: (1) participant's satisfaction covers: participant's satisfaction to widyaiswara or resource person, participant's satisfaction to organizer committee service, participant's satisfaction on training materials, participant's satisfaction on training schedule, Participants on training facilities and infrastructure, and participant's satisfaction with the training consumption; (2) learning activities include: participant activity in learning process, widyaiswara activity or resource in learning process, and organizer activity of organizer in learning process; (3) changes in the behavior of alumni after returning to their respective duties, including: behavioral changes in implementing management functions, behavior change in task delegation, behavior change in coordination, and behavior change in decision making; (4) Impact of change in employment behavior of alumni to improve agency performance; and (5) Impact of change in work behavior of alumni to improve service quality of institution.
Keywords: Evaluation, Educational, Training and Leaderships.
MANAGING ORGANIZATIONAL CITIZENSHIP BEHAVIOR HUMAN RESOURCES OF EDUCATION IN BASIC SCHOOL IN THE SERANG CITY
Authors: Pancasasti Ranthy 
Published: October 2019

The purpose of this research is to know the direct influence of transformational leadership, organizational climate, team work, and emotional intelligence toward organizational citizenship behavior of human resources at State Elementary School in Serang City. This study used survey methods, and included in quantitative research. The number of population in this study as many as 433 people, the sample amounted to 100 people, taken by random sampling technique. Method of data collection were conducted by interviews, questionnaires, and documentation studies. The result of the research shows that there are positive direct influence of transformational leadership, organizational climate, team work, and emotional intelligence toward the organizational citizenship behavior of human resources personnel at elementary school in Serang city. The emotional intelligence factor is the variable that has the greatest influence on the organizational citizenship behavior. Teamwork factor is the smallest variable of influence on organizational citizenship behavior.
Keywords: Transformational Leadership, Organizational Climate, Team Work, Emotional Intelligence, and Organizational Citizenship Behavior.