bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrical and Crystallographic Study of an Electrothermodynamic Cycle for a Waste Heat Recovery
Authors: Kim Juyoung , Yamanaka Satoru , Nakajima Akira , Katou Takanori , Kim Juyoung , Kim Yoonho , Fukuda Tatsuo , Yoshii Kenji , Nishihata Yasuo , Baba Masaaki , Takeda Masatoshi , Yamada Noboru , Nakayama Tadachika , Tanaka Hirohisa 
Published: August 2018

AbstractFor decades, wasted heat has increased, and the thermal energy conversion system has become more important, especially in automobile applications. For waste heat recovery, an innovative electrothermodynamic cycle (pyroelectric effect with an external electric field) was recently presented, which is based on temporal temperature variations in wasted heat from engine exhaust gas. Herein, for further improvement, a generating mechanism of the cycle is investigated via an Operando analysis, time‐resolved synchrotron X‐ray diffraction with generating assessment. Polarization changes are analyzed via simultaneous electrical and crystallographic studies. Three types of materials are prepared: soft and hard types of PZTs and lead magnesium niobate—lead titanate (PMN‐PT). Among them, PMN‐PT has the highest generating power. When an external electric field is applied, the PMN‐PT exhibits only 180° domain rotations, whereas the other materials exhibit both 90° and 180° rotations. A strong driving force for 180° rotation depresses rotations in other angles and increases polarization changes. The results show that the material development, which has only 180° switching domains, has potential for use in the establishment of a high‐efficiency waste heat recovery system.
Polydopamine‐Modified Black Phosphorous Nanocapsule with Enhanced Stability and Photothermal Performance for Tumor Multimodal Treatments
Authors: Zeng Xiaowei , Luo Miaomiao , Liu Gan , Wang Xusheng , Tao Wei , Lin Yaoxin , Ji Xiaoyuan , Nie Lin , Mei Lin 
Published: August 2018

AbstractAs a novel 2D material, black phosphorus (BP) nanosheets are considered as a promising candidate for drug delivery platform for synergistic chemo/photothermal therapy. However, the intrinsic instability of bare BP poses a challenge in its biomedical applications. To date, some strategies have been employed to prevent BP from rapid ambient degradation. Unfortunately, most of these strategies are not suitable for the drug delivery systems. Here, a simple polydopamine modification method is developed to enhance the stability and photothermal performance of bare BP nanosheets. Then, this nanocapsule is used as a multifunctional codelivery system for the targeted chemo, gene, and photothermal therapy against multidrug‐resistant cancer. The enhanced tumor therapy effect is demonstrated by both in vitro and in vivo studies.
A Broad‐Spectrum ROS‐Eliminating Material for Prevention of Inflammation and Drug‐Induced Organ Toxicity
Authors: Li Lanlan , Guo Jiawei , Wang Yuquan , Xiong Xiaoxing , Tao Hui , Li Jin , Jia Yi , Hu Houyuan , Zhang Jianxiang 
Published: August 2018

AbstractDespite the great potential of numerous antioxidants for pharmacotherapy of diseases associated with inflammation and oxidative stress, many challenges remain for their clinical translation. Herein, a superoxidase dismutase/catalase‐mimetic material based on Tempol and phenylboronic acid pinacol ester simultaneously conjugated β‐cyclodextrin (abbreviated as TPCD), which is capable of eliminating a broad spectrum of reactive oxygen species (ROS), is reported. TPCD can be easily synthesized by sequentially conjugating two functional moieties onto a β‐cyclodextrin scaffold. The thus developed pharmacologically active material may be easily produced into antioxidant and anti‐inflammatory nanoparticles, with tunable size. TPCD nanoparticles (TPCD NP) effectively protect macrophages from oxidative stress‐induced apoptosis in vitro. Consistently, TPCD NP shows superior efficacies in three murine models of inflammatory diseases, with respect to attenuating inflammatory responses and mitigating oxidative stress. TPCD NP can also protect mice from drug‐induced organ toxicity. Besides the passive targeting effect, the broad spectrum ROS‐scavenging capability contributes to the therapeutic benefits of TPCD NP. Importantly, in vitro and in vivo preliminary experiments demonstrate the good safety profile of TPCD NP. Consequently, TPCD in its native and nanoparticle forms can be further developed as efficacious and safe therapies for treatment of inflammation and oxidative stress‐associated diseases.
Operative time and cost variability for functional endoscopic sinus surgery
Authors: Thomas Andrew J. , Smith Kristine A. , Newberry Christopher I. , Cardon Brandon , Davis Brock , Ou Zhining , Presson Angela P. , Meier Jeremy D. , Alt Jeremiah A. 
Published: August 2018

BackgroundUnderstanding the variation in costs of endoscopic sinus surgery (ESS) is critical to defining value. Current published costs of ESS have not identified potential sources of variation. Our objective was to analyze ESS costs to identify sources of variance that could guide value‐improving decisions.MethodsESS cases (n = 1739) performed between 2008 and 2016 were identified from a database of 22 rural to tertiary facilities. Cost and time data were extracted from the database. Medical records were reviewed to confirm procedures. Three bilateral groupings were examined (n = 895 cases from 13 facilities): (1) full ESS (all sinuses); (2) intermediate ESS (total ethmoid, maxillary); and (3) anterior ESS (anterior ethmoid, maxillary). Cost and operative time were analyzed using multivariable gamma regression.ResultsMedian costs for full, intermediate, and anterior ESS were $4281, $3716, and $2549 U.S. dollars (p < 0.001). Median durations were 87, 60, and 58 minutes (p < 0.001). Among patients with no additional procedures, those with full ESS had operative duration, total cost, and supply costs that were 1.37 (95% confidence interval [CI], 1.17 to 1.61), 1.52 (95% CI, 1.32 to 1.75), and 2.40 (95% CI, 1.76 to 3.25) times greater than anterior ESS, respectively (all p < 0.001). Intermediate ESS duration at community urban facilities was 1.87 (95% CI, 1.74 to 2.02) times that of community rural facilities (p < 0.001).ConclusionDuration of surgery, extent of surgery, and location of surgery are sources of significant variation in the cost of ESS. These findings will assist healthcare policy makers, hospitals, and surgeons in optimizing the value of ESS.
Electronic Properties of Strained Double‐Weyl Systems
Authors: Sukhachov Pavlo O. , Gorbar Eduard V. , Shovkovy Igor A. , Miransky Vladimir A. 
Published: August 2018

AbstractThe effects of strains on the low‐energy electronic properties of double‐Weyl phases are studied in solids and cold‐atom optical lattices. The principal finding is that deformations do not couple, in general, to the low‐energy effective Hamiltonian as a pseudoelectromagnetic gauge potential. The response of an optical lattice to strains is simpler, but still only one of the several strain‐induced terms in the corresponding low‐energy Hamiltonian can be interpreted as a gauge potential. Most interestingly, the strains can induce a nematic order parameter that splits a double‐Weyl node into a pair of Weyl nodes with the unit topological charges. The effects of deformations on the motion of wavepackets in the double‐Weyl optical lattice model are studied. It is found that, even in the undeformed lattices, the wavepackets with opposite topological charges can be spatially split. Strains, however, modify their velocities in a very different way and lead to a spin polarization of the wavepackets.
Building and Breaking Bonds via a Compact S‐Propargyl‐Cysteine to Chemically Control Enzymes and Modify Proteins
Authors: Liu Jun , Cheng Rujin , Wu Haifan , Li Shanshan , Wang Peng G. , DeGrado William F. , Rozovsky Sharon , Wang Lei 
Published: August 2018

AbstractAnalogous to reversible post‐translational protein modifications, the ability to attach and subsequently remove modifications on proteins would be valuable for protein and biological research. Although bioorthogonal functionalities have been developed to conjugate or cleave protein modifications, they are introduced into proteins on separate residues and often with bulky side chains, limiting their use to one type of control and primarily protein surface. Here we achieved dual control on one residue by genetically encoding S‐propargyl‐cysteine (SprC), which has bioorthogonal alkyne and propargyl groups in a compact structure, permitting usage in protein interior in addition to surface. We demonstrated its incorporation at the dimer interface of glutathione transferase for in vivo crosslinking via thiol–yne click chemistry, and at the active site of human rhinovirus 3C protease for masking and then turning on enzyme activity via Pd‐cleavage of SprC into Cys. In addition, we installed biotin onto EGFP via Sonogashira coupling of SprC and then tracelessly removed it via Pd cleavage. SprC is small in size, commercially available, nontoxic, and allows for bond building and breaking on a single residue. Genetically encoded SprC will be valuable for chemically controlling proteins with an essential Cys and for reversible protein modifications.
α‐Sila‐Dipeptides: Synthesis and Characterization
Authors: Minkovich Boris , Ruderfer Ilya , Kaushansky Alexander , Bravo‐Zhivotovskii Dmitry , Apeloig Yitzhak 
Published: August 2018

AbstractThe first two α‐sila‐dipeptides, 7 and cyclo‐sila‐dipeptide 8, were synthesized and characterized by several methods, including X‐ray crystallography. Bulky t‐BuMe2Si substituents provide some kinetic stabilization to the synthesized molecules. 7 and 8 are the first examples of a “Si for C switch” in the central α‐position of an amino acid or a peptide, in which silicon is bonded to both the amino and the carbonyl groups.
Highly Regioselective Domino Benzannulation Reaction of Buta‐1,3‐diynes To Construct Irregular Nanographenes
Authors: Yang Wenlong , Bam Radha , Catalano Vincent J. , Chalifoux Wesley A. 
Published: August 2018

AbstractThe properties of nanographenes can be tuned by changing their shapes, therefore the development of new methods suitable for the synthesis of various nanographenes is highly desirable. Described herein is an intramolecular InCl3/AgNTf2‐catalyzed regioselective domino benzannulation reaction of buta‐1,3‐diynes to build irregular nanographenes. Different nanographene compounds were easily obtained in moderate to high yields through careful design of the precursor compounds. This new domino reaction was successfully applied to a fourfold alkyne benzannulation of dimethoxy‐1,1′‐binaphthalene derivatives to arrive at novel chiral butterfly ligand precursors. The regioselectivity of the benzannulation reaction was unambiguously confirmed by X‐ray crystallography. Moreover, this new method enables us to synthesize different nanographene isomers and study their optical properties as a function of shape.
Synthesis and characterization of a new nanocomposite (FeW11V@CTAB‐MMT) as an efficient heterogeneous catalyst for oxidative desulfurization of gasoline
Authors: Rezvani Mohammad Ali , Khandan Sahar 
Published: August 2018

A new nanocomposite (FeW11V@CTAB‐MMT) was designed on the basis of vanadium‐substituted tungstoferrate (FeW11V) and cetyltrimethylammonium bromide‐modified montmorillonite (CTAB‐MMT) as an efficient nanocatalyst for oxidative desulfurization (ODS) of gasoline. The synthesized catalyst was characterized using various techniques. To evaluate the catalytic activity of FeW11V@CTAB‐MMT, ODS was carried out using a mixture of aqueous acetic acid and hydrogen peroxide solution as an oxidant and acetonitrile solvent as an extractant. The ODS results revealed that the removal efficiencies of thiophene, benzothiophene and dibenzothiophene were more than 97% in the presence of the FeW11V@CTAB‐MMT catalyst at 35 °C after 1 h. Kinetics of the catalytic ODS reactions was found to be pseudo‐first‐order. The prepared heterogeneous catalyst was found to be reusable for five runs without a discernible decrease in its activity. The current research provides insight into a new catalytic system for the ODS process for the deep removal of hazardous sulfur molecules from gasoline.
Bilanzierung des baulichen Schallschutzes nach DIN 4109:2016‐07 für Wohnbauten aus Leichtbeton
Authors: Krechting Andreas 
Published: August 2018

AbstractFür die zuverlässige Umsetzung von Schallschutzzielen ist eine möglichst genaue Bilanzierung nötig. Gerade im Wohnbau ist dies von höchster Priorität. Die Anpassung der DIN 4109:2016 ist dabei ein Schritt in die richtige Richtung. Die Berücksichtigung der Schallnebenwege zur Berechnung trennender Bauteile – speziell auch in Mehrfamilienhäusern – ermöglicht genauere Prognosen der Schalldämmung als zuvor. Dies erleichtert vor allem die Planung sensibler Wohnbereiche. Mauerwerk aus KLB‐Leichtbeton kann hier durch seine spezielle Struktur einen wichtigen Beitrag leisten.
A note on pseudo‐observations and left‐truncation
Authors: Grand Mia K. , Putter Hein , Allignol Arthur , Andersen Per K. 
Published: August 2018

AbstractPseudo‐observations have been introduced as a way to perform regression analysis of a mean value parameter related to a right‐censored time‐to‐event outcome, such as the survival probability or the restricted mean survival time. Since the introduction of the approach there have been several extensions from the original setting. However, the proper definition and performance of pseudo‐observations under left‐truncation has not yet been addressed. Here, we look at two types of pseudo‐observations under right‐censoring and left‐truncation. We explored their performance in a simulation study and applied them to data on diabetes patients with left‐truncation.
Development and validation of a UPLC–MS/MS method for quantification of osimertinib (AZD9291) and its metabolite AZ5104 in human plasma
Authors: Zheng Xin , Wang Weicong , Zhang Yanbao , Ma Yuxiang , Zhao Hongyun , Hu Pei , Jiang Ji 
Published: August 2018

AbstractOsimertinib (AZD9291) is a highly selective irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) designed to treat nonsmall‐cell lung cancer patients with EGFR active and T790 M resistant mutations. A rapid and sensitive method for quantitative analysis by ultra‐performance liquid chromatography–tandem mass spectrometry of osimertinib and its metabolite AZ5104 in human plasma was developed and validated. The samples were prepared by protein precipitation and separated on a BEH C18 column (2.1 × 50 mm, 1.7 μm) by gradient elution with 0.1% (v/v) formic acid and 10 mm ammonium acetate in water and acetonitrile as the mobile phase. Electrospray ionization in positive ion mode and multiple reaction monitoring were used to monitor the ion transitions at m/z 500.4 → 385.3 and 486.3 → 371.1. The results indicated that the method had excellent sensitivity and specificity. The validation was performed in a range from 0.5 to 100 ng/mL. Intra‐day and inter‐day precisions (in terms of RSD) were all <15%, and the accuracies (in terms of RE) were within ±15%. The lower limit of quantification, matrix effect, extraction recovery, stability and dilution integrity were also validated and satisfied the validation criteria. Finally, this method was successfully applied in a retrospective analysis, and the predose samples of 52 nonsmall‐cell lung cancer patients who were enrolled in a novel third EGFR TKI clinical trial were analyzed for screening regardless of whether they had previously received osimertinib treatments.
Profiles of immune infiltration in colorectal cancer and their clinical significant: A gene expression‐based study
Authors: Xiong Yongfu , Wang Kang , Zhou He , Peng Linglong , You Wenxian , Fu Zhongxue 
Published: August 2018

AbstractImmune infiltration of colorectal cancer (CRC) is closely associated with clinical outcome. However, previous work has not accounted for the diversity of functionally distinct cell types that make up the immune response. In this study, based on a deconvolution algorithm (known as CIBERSORT) and clinical annotated expression profiles, we comprehensively analyzed the tumor‐infiltrating immune cells present in CRC for the first time. The fraction of 22 immune cells subpopulations was evaluated to determine the associations between each cell type and survival and response to chemotherapy. As a result, profiles of immune infiltration vary significantly between paired cancer and paracancerous tissue and the variation could characterize the individual differences. Of the cell subpopulations investigated, tumors lacking M1 macrophages or with an increased number of M2 macrophages, eosinophils, and neutrophils were associated with the poor prognosis. Unsupervised clustering analysis using immune cell proportions revealed five subgroups of tumors, largely defined by the balance between macrophages M1, M2, and NK resting cells, with distinct survival patterns, and associated with well‐established molecular subtype. Collectively, our data suggest that subtle differences in the cellular composition of the immune infiltrate in CRC appear to exist, and these differences are likely to be important determinants of both prognosis and response to treatment.
Oxidation of Sulfurous Acid on Carbon Catalysts as a Test Reaction Revisited: Potential and Limitations
Authors: Klepel Olaf , Lange Felix , Utgenannt Stephan 
Published: August 2018

AbstractSome decades ago, the oxidation of sulfurous acid in aqueous solution was described as a probe reaction to characterize carbon‐based catalysts in redox reactions. Since then, the importance of porous carbon materials in the redox catalysis increased enormously because of the new challenges in developing energy‐saving alternatives to industrial catalyst systems or catalysts for energy conversion applications. Therefore, there is an growing interest in rapid and reliable tools to characterize such catalysts. However, the use of oxidation of sulfurous acid as a test reaction fell appearently into oblivion. The aim of the present article is to evaluate its potential and limitations and to suggest improvements.
Synthesis of Benzannulated Medium‐Ring Lactams via a Tandem Oxidative Dearomatization‐Ring Expansion Reaction
Authors: Guney Tezcan , Wenderski Todd A. , Boudreau Matthew W. , Tan Derek S. 
Published: August 2018

AbstractInvited for the cover of this issue is the group of Derek S. Tan at the Memorial Sloan Kettering Cancer Center. The image depicts the East River in New York City, whose current reverses direction in response to tidal events, analogous to reversal of electron flow in the accompanying tandem reaction. Read the full text of the article at 10.1002/chem.201802880.
Emotion‐focused therapy for binge‐eating disorder: A review of six cases
Authors: Glisenti Kevin , Strodl Esben , King Robert 
Published: August 2018

AbstractObjectiveThis study aimed to provide preliminary evidence of the usefulness of emotion‐focused therapy (EFT) for binge‐eating disorder (BED).MethodsWe used a single‐subject design in which 12 weeks of individual EFT were applied nonconcurrently to six female adult participants with BED, following three weekly baseline sessions. Participants were assessed for binge‐eating psychopathology and emotion regulation difficulties on a weekly basis during baseline and treatment. They were assessed on a 2‐, 4‐, and 8‐week basis during posttreatment, and they were assessed for binge‐eating episodes, eating disorder attitudes, alexithymia, and psychiatric comorbidity at pretreatment and posttreatment.ResultsAll cases experienced reliable recovery from binge‐eating psychopathology and a significant decrease in binge‐eating frequency. For all cases, there was reliable improvement or recovery on eating and shape concerns, and there was improvement on weight concern for the majority of cases. For all cases, reliable recovery or improvement occurred in overall emotion regulation. Most cases that were in the clinical range pretreatment recovered for anxiety, and reliable improvement in or recovery from depression occurred for all cases. There was reliable recovery or improvement in alexithymia for half of the cases; however, the other half experienced no change or deteriorated. There were no treatment dropouts.ConclusionIndividual EFT demonstrates potential as a psychological treatment for BED. The current study provides preliminary evidence to guide the development of a more extensive trial to test the efficacy of individual EFT for BED as well as to identify possible mechanisms of change.
Neural network‐based design of 2‐channel quadrature mirror filter banks
Authors: Jou Yue‐Dar , Lin Zhan‐Pei , Chen Fu‐Kun 
Published: August 2018

SummaryTwo‐channel quadrature mirror filter banks can be efficiently established by the combination of real‐valued infinite impulse response all‐pass filters without incurring aliasing and magnitude distortions. The design problem of filter banks is therefore to seek for the phase error minimization of the all‐pass filter coefficients. In this paper, a neural network‐based Lyapunov energy function is used to relate to the objective function of the designed all‐pass filter coefficients. Based on the architecture of neural networks and suitable selection of Hopfield‐related parameters, the all‐pass filter coefficients are obtained when the networks reach convergence. By further using the suitable combination of the designed all‐pass filters, the 2‐channel quadrature mirror filter banks with perfect reconstruction can be efficiently accomplished. Simulation results indicate that the neural network‐based approach has the advantage of satisfactory performance in magnitude and group delay responses in a parallelism manner.
Multiplicative based path loss model
Authors: Bilgehan Bülent , Ojo Stephen 
Published: August 2018

SummaryWe present a newly introduced multiplicative based path loss model for the wireless channel. The model verified with experimental data at 2100 MHz collected across Cyprus in 6 existing microcells in urban, suburban, and rural areas. The new method uses the multiplicative least square fitting model that relates the decibel path loss to the distance with parameterized exponential‐type basis. The parameters are extracted from the real‐time measured values. The resulting path loss models apply to single‐cell arrangement with base antenna heights from 25 to 45 m and base‐to‐terminal distances from 0.1 to 2 km. The newly generated multiplicative base path loss model tested and compared with the best existing suitable models. The validity of the new model verified using relative error analysis. The new model can be used to determine accurately the path loss for microcells in the wireless coverage area as well as in the applications of data analysis.