bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral health and later coronary heart disease: Cohort study of one million people
Authors: Batty G David , Jung Keum Ji , Mok Yejin , Lee Sun Ju , Back Joung Hwan , Lee Sunmi , Jee Sun Ha 
Published: February 2018

AimsSystematic reviews report an association between poorer oral health and an increased risk of coronary heart disease. This contentious relationship may not be causal but existing studies have been insufficiently well powered comprehensively to examine the role of confounding, particularly by cigarette smoking. Accordingly, we sought to examine the role of smoking in generating the relationship between oral health and coronary heart disease in life-long non-smokers.Methods and resultsIn the Korean Cancer Prevention Study, 975,685 individuals (349,579 women) aged 30–95 years had an oral examination when tooth loss, a widely used indicator of oral health, was ascertained. Linkage to national mortality and hospital registers over 21 years of follow-up gave rise to 64,784 coronary heart disease events (19,502 in women). In the whole cohort, after statistical adjustment for age, there was a moderate, positive association between tooth loss and coronary heart disease in both men (hazard ratio for seven or more missing teeth vs. none; 95% confidence interval 1.08; 1.02, 1.14; Ptrendacross tooth loss groups <0.0001) and women (1.09; 1.01, 1.18; Ptrend0.0016). Restricting analyses to a subgroup of 464,145 never smokers (25,765 coronary heart disease events), however, resulted in an elimination of this association in men (1.01; 0.85, 1.19); Ptrend0.7506) but not women (1.08; 0.99, 1.18; Ptrend0.0086).ConclusionIn men in the present study, the relationship between poor oral health and coronary heart disease risk appeared to be explained by confounding by cigarette smoking so raising questions about a causal link.
Hospital and clinical care costs associated with atrial fibrillation for Medicare beneficiaries in the Cardiovascular Health Study and the Framingham Heart Study
Authors: Delaney Joseph AC , Yin Xiaoyan , Fontes João Daniel , Wallace Erin R , Skinner Asheley , Wang Na , Hammill Bradley G , Benjamin Emelia J , Curtis Lesley H , Heckbert Susan R 
Published: February 2018

Background: Atrial fibrillation is increasingly prevalent as the US population ages and is associated with significant morbidity and mortality. Care for patients with atrial fibrillation can be costly, US health care costs are comparatively high, and there are few cost estimates available that incorporate detailed measurement of comorbidities and their effects on costs. Methods and Results: In the Cardiovascular Health Study and the Framingham Heart Study, participants aged 65 years or older with newly diagnosed atrial fibrillation were matched on age and follow-up time to referents free of atrial fibrillation. The total clinical and hospital medical costs paid by Medicare Parts A and B (drug costs from Medicare Part D costs were not included) in the year prior to diagnosis (or matching) were compared with costs in the following year. Estimates were adjusted for other medical conditions and adjusted to 2009 dollars. In the Cardiovascular Health Study, 513 participants were diagnosed with new-onset atrial fibrillation and survived 30 days post-atrial fibrillation diagnosis, and 513 referents (as a control cohort) were identified, with a mean age of 77 years. In the Framingham Heart Study, we identified 336 participants diagnosed with atrial fibrillation, who survived 30 days post-atrial fibrillation diagnosis and matched these participants to 336 referents. We compared these new-onset atrial fibrillation participants with referents, using a difference in difference design to account for both time trends and differences between the two groups. The adjusted incremental cost for participants with atrial fibrillation, compared with referents, was US$18,060 (95% confidence interval: US$14,965–US$21,155) in the Cardiovascular Health Study and US$20,012 (95% confidence interval: US$15,057–US$24,966) in the Framingham Heart Study. The pooled estimate was US$18,601 (95% confidence interval: US$15,981–US$21,234). Conclusion: Atrial fibrillation was associated with increased costs in the year after diagnosis in two community-based cohorts, even after careful accounting for age, time period, and systematically measured comorbidities.
Spiritually Integrated Cognitive Processing Therapy: A New Treatment for Post-traumatic Stress Disorder That Targets Moral Injury
Authors: Pearce Michelle , Haynes Kerry , Rivera Natalia R , Koenig Harold G. 
Published: February 2018

Background Post-traumatic stress disorder (PTSD) is a debilitating disorder, and current treatments leave the majority of patients with unresolved symptoms. Moral injury (MI) may be one of the barriers that interfere with recovery from PTSD, particularly among current or former military service members. Objective Given the psychological and spiritual aspects of MI, an intervention that addresses MI using spiritual resources in addition to psychological resources may be particularly effective in treating PTSD. To date, there are no existing empirically based individual treatments for PTSD and MI that make explicit use of a patient’s spiritual resources, despite the evidence that spiritual beliefs/activities predict faster recovery from PTSD. Method To address this gap, we adapted Cognitive Processing Therapy (CPT), an empirically validated treatment for PTSD, to integrate clients’ spiritual beliefs, practices, values, and motivations. We call this treatment Spiritually Integrated CPT (SICPT). Results This article describes this novel manualized therapeutic approach for treating MI in the setting of PTSD for spiritual/religious clients. We provide a description of SICPT and a brief summary of the 12 sessions. Then, we describe a case study in which the therapist helps a client use his spiritual resources to resolve MI and assist in the recovery from PTSD. Conclusion SICPT may be a helpful way to reduce PTSD by targeting MI, addressing spiritual distress, and using a client’s spiritual resources. In addition to the spiritual version (applicable for those of any religion and those who do not identify as religious), we have also developed 5 religion-specific manuals (Christianity, Judaism, Islam, Buddhism, and Hinduism) for clients who desire a more religion-specific approach.
Anterior Cruciate Ligament Reconstruction in Skeletally Immature Patients: Early Results Using a Hybrid Physeal-Sparing Technique
Authors: Willson Robert G. , Kostyun Regina O. , Milewski Matthew D. , Nissen Carl W. 
Published: February 2018

Background: Reconstruction of the anterior cruciate ligament (ACL) in the skeletally immature patient is frequently performed in hopes of preventing new or additional chondral damage and meniscal injuries. Patients within a few years of skeletal maturity are more at risk for ACL injuries than prepubescent patients, about whom several physeal-sparing techniques have been described. Reconstruction techniques in the former higher risk group need to be better understood. Purpose: To review a series of adolescent patients with ACL injuries surgically treated with the hybrid physeal-sparing technique. Study Design: Case series; Level of evidence, 4. Methods: Surgical logs of ACL reconstructions (ACLRs) performed at a single pediatric/adolescent sports medicine center over a 6-year period were reviewed. Patients with open physes who had undergone ACLR with a femoral physeal-sparing tunnel and transphyseal tibial tunnel were identified. Their demographics, operative reports, rehabilitative course, time to return to play, outcome scores, and postoperative radiographs were collected and analyzed. Results: Twenty-three patients with a mean chronological age and bone age of 13.0 and 13.6 years, respectively, were identified. Examination and subjective outcome scores were obtained at a mean of 19 months and overall demonstrated positive results, with a mean Pediatric International Knee Documentation Committee (Pedi-IKDC) score of 96.0 and a mean Anterior Cruciate Ligament–Return to Sport after Injury (ACL-RSI) score of 89.1. Full-length mechanical axis films obtained at a mean 21 months postoperatively demonstrated no leg-length discrepancies or angular deformities in 21 of 23 patients. Two patients had an identified growth disturbance in the form of femoral and tibial growth acceleration on the ACL-reconstructed limb. Conclusion: The femoral physeal-sparing with transphyseal tibial drilling “hybrid” technique in skeletally maturing patients appears to have a high rate of success with low morbidity. However, the possibility of physeal abnormalities does exist, which demonstrates the importance of a close postoperative follow-up and evaluation until skeletal maturity is achieved. ACLR in skeletally immature patients is performed on an increasingly regular basis. Establishing the best and safest technique to do so is therefore important.
Mentoring Clinical-Year Medical Students: Factors Contributing to Effective Mentoring
Authors: Fallatah Hind I , Soo Park Yoon , Farsi Jamila , Tekian Ara 
Published: February 2018

Theory: Academic mentoring is an effective method of enhancing undergraduate medical student academic performance, research productivity, career planning, and overall satisfaction. Hypotheses: This study investigates the relationship between mentor characteristics and mentee academic performance, with an emphasis on identifying students who need special support. Methods: A cross-sectional study was conducted among fourth-year medical students at King Abdulaziz University Faculty of Medicine undertaking the clinical skills module (CSM) rotation. Mentors included senior and junior faculty members from the Department of Internal Medicine and the Department of Family Medicine. King Abdulaziz University Faculty of Medicine assigned 1 mentor for every 10 medical students. We organized our mentoring program in the following format: (1) an initial group meeting (mentor with all 10 medical students) and (2) subsequent one-on-one meetings (mentor with each mentee alone). We assessed mentor characteristics, student academic performance and satisfaction, and the rate of mentees referred for special support. Results: A total of 184 students completed the CSM rotation. Among these, 90 students responded to the preprogram survey, with 83% reporting that mentoring was important to them. Group meetings and one-on-one meetings were attended by 60% and 49% of all students, respectively. The most frequent type of support required by the participating students was psychological support (12% of mentees). Participation in the mentoring program had no significant effect on student academic performance. Mentor seniority ( P = .024) and motivation ( P = .002) were significantly associated with the rate of student referral for special support. Conclusions: This study demonstrated that academic mentoring can be effective in enhancing student outcomes and promoting special support for students. Moreover, mentor and mentee motivation were found to be essential elements of a successful mentoring program.
mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8
Authors: Zhao Yang , Shen Xiaofei , Na Ning , Chu Zhulang , Su Huiting , Chao Shanshan , Shi Lu , Xu Yanan , Zhang Lianfeng , Shi Bingyi , Zhao Yong 
Published: February 2018

Key Points
mTOR intrinsically controls monocyte/macrophage development in the early stage. mTOR masters monocyte development via the STAT5-IRF8-CD115 pathway.
First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation
Authors: Romee Rizwan , Cooley Sarah , Berrien-Elliott Melissa M. , Westervelt Peter , Verneris Michael R. , Wagner John E. , Weisdorf Daniel J. , Blazar Bruce R. , Ustun Celalettin , DeFor Todd E. , Vivek Sithara , Peck Lindsey , DiPersio John F. , Cashen Amanda F. , Kyllo Rachel , Musiek Amy , Schaffer András , Anadkat Milan J. , Rosman Ilana , Miller Daniel , Egan Jack O. , Jeng Emily K. , Rock Amy , Wong Hing C. , Fehniger Todd A. , Miller Jeffrey S. 
Published: February 2018

Key Points
Single-agent IL-15/IL-15Rα-Fc (ALT-803) therapy was well tolerated and resulted in clinical responses in patients who relapsed post-HCT. First-in-human use of ALT-803 promoted NK and CD8+ T-cell expansion and activation in vivo without stimulating regulatory T cells.
Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients
Authors: Tényi Ákos , Cano Isaac , Marabita Francesco , Kiani Narsis , Kalko Susana G. , Barreiro Esther , de Atauri Pedro , Cascante Marta , Gomez-Cabrero David , Roca Josep 
Published: February 2018

AbstractBackgroundChronic obstructive pulmonary disease (COPD) patients often show skeletal muscle dysfunction that has a prominent negative impact on prognosis. The study aims to further explore underlying mechanisms of skeletal muscle dysfunction as a characteristic systemic effect of COPD, potentially modifiable with preventive interventions (i.e. muscle training). The research analyzes network module associated pathways and evaluates the findings using independent measurements.MethodsWe characterized the transcriptionally active network modules of interacting proteins in the vastus lateralis of COPD patients (n = 15, FEV146 ± 12% pred, age 68 ± 7 years) and healthy sedentary controls (n = 12, age 65 ± 9 years), at rest and after an 8-week endurance training program. Network modules were functionally evaluated using experimental data derived from the same study groups.ResultsAt baseline, we identified four COPD specific network modules indicating abnormalities in creatinine metabolism, calcium homeostasis, oxidative stress and inflammatory responses, showing statistically significant associations with exercise capacity (VO2peak, Watts peak, BODE index and blood lactate levels) (P < 0.05 each), but not with lung function (FEV1). Training-induced network modules displayed marked differences between COPD and controls. Healthy subjects specific training adaptations were significantly associated with cell bioenergetics (P < 0.05) which, in turn, showed strong relationships with training-induced plasma metabolomic changes; whereas, effects of training in COPD were constrained to muscle remodeling.ConclusionIn summary, altered muscle bioenergetics appears as the most striking finding, potentially driving other abnormal skeletal muscle responses.Trial registrationThe study was based on a retrospectively registered trial (May 2017), ClinicalTrials.gov identifier:NCT03169270
Comparison of governance approaches for the control of antimicrobial resistance: Analysis of three European countries
Authors: Birgand Gabriel , Castro-Sánchez Enrique , Hansen Sonja , Gastmeier Petra , Lucet Jean-Christophe , Ferlie Ewan , Holmes Alison , Ahmad Raheelah 
Published: February 2018

AbstractPolicy makers and governments are calling for coordination to address the crisis emerging from the ineffectiveness of current antibiotics and stagnated pipe-line of new ones – antimicrobial resistance (AMR). Wider contextual drivers and mechanisms are contributing to shifts in governance strategies in health care, but are national health system approaches aligned with strategies required to tackle antimicrobial resistance? This article provides an analysis of governance approaches within healthcare systems including: priority setting, performance monitoring and accountability for AMR prevention in three European countries: England, France and Germany. Advantages and unresolved issues from these different experiences are reported, concluding that mechanisms are needed to support partnerships between healthcare professionals and patients with democratized decision-making and accountability via collaboration. But along with this multi-stakeholder approach to governance, a balance between regulation and persuasion is needed.
Multi-view large population gait dataset and its performance evaluation for cross-view gait recognition
Authors: Takemura Noriko , Makihara Yasushi , Muramatsu Daigo , Echigo Tomio , Yagi Yasushi 
Published: February 2018

AbstractThis paper describes the world’s largest gait database with wide view variation, the “OU-ISIR gait database, multi-view large population dataset (OU-MVLP)”, and its application to a statistically reliable performance evaluation of vision-based cross-view gait recognition. Specifically, we construct a gait dataset that includes 10,307 subjects (5114 males and 5193 females) from 14 view angles ranging 0° −90°, 180° −270°.In addition, we evaluate various approaches to gait recognition which are robust against view angles. By using our dataset, we can fully exploit a state-of-the-art method requiring a large number of training samples, e.g., CNN-based cross-view gait recognition method, and we validate effectiveness of such a family of the methods.
Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update
Authors: Taplitz Randy A. , Kennedy Erin B. , Bow Eric J. , Crews Jennie , Gleason Charise , Hawley Douglas K. , Langston Amelia A. , Nastoupil Loretta J. , Rajotte Michelle , Rolston Kenneth , Strasfeld Lynne , Flowers Christopher R. 
Published: February 2018

Purpose To provide an updated joint ASCO/Infectious Diseases Society of American (IDSA) guideline on outpatient management of fever and neutropenia in patients with cancer. Methods ASCO and IDSA convened an Update Expert Panel and conducted a systematic review of relevant studies. The guideline recommendations were based on the review of evidence by the Expert Panel. Results Six new or updated meta-analyses and six new primary studies were added to the updated systematic review. Recommendation Clinical judgment is recommended when determining which patients are candidates for outpatient management, using clinical criteria or a validated tool such as the Multinational Association of Support Care in Cancer risk index. In addition, psychosocial and logistic considerations are outlined within the guideline. The panel continued to endorse consensus recommendations from the previous version of this guideline that patients with febrile neutropenia receive initial doses of empirical antibacterial therapy within 1 hour of triage and be monitored for ≥ 4 hours before discharge. An oral fluoroquinolone plus amoxicillin/clavulanate (or clindamycin, if penicillin allergic) is recommended as empirical outpatient therapy, unless fluoroquinolone prophylaxis was used before fever developed. Patients who do not defervesce after 2 to 3 days of an initial, empirical, broad-spectrum antibiotic regimen should be re-evaluated and considered as candidates for inpatient treatment. Additional information is available at www.asco.org/supportive-care-guidelines and www.asco.org/guidelineswiki .
Allenedicarboxylate as a Stereochemically Labile Electrophile for Chiral Organic Base-catalyzed Stereoselective Michael Addition
Authors: Uraguchi Daisuke , Kawai Yasutaka , Sasaki Hitoshi , Yamada Kohei , Ooi Takashi 
Published: February 2018

Abstract
A highly stereoselective Michael addition of α-amino acid-derived 2-benzyloxythiazol-5(4H)-ones to dimethyl allenedicarboxylate was developed by employing P-spiro chiral triaminoiminophosphorane bearing (S)-sec-butyl groups as a catalyst. Theoretical investigation of the transition-state models for the reaction and control experiments suggested the intervention of a dynamic kinetic resolution of the axially chiral allene acceptor. The synthetic utility of this method was demonstrated through the transformation of the stereochemically homogeneous Michael adduct to an α-vinylic α-amino acid derivative.
ОСОБЕННОСТИ РАЗРАБОТКИ УЧЕБНЫХ МАТЕРИАЛОВ ПРИ ПРИМЕНЕНИИ ТЕХНОЛОГИИ РЕВЕРСИВНОГО ОБУЧЕНИЯ
Authors: Tomashevskaya Irina Valerievna 
Published: February 2018

Статья посвящена исследованию образовательной технологии реверсивного обучения и применению ее на практике. Актуальность заявленной темы связана с возрастающей популярностью использования современного Интернет пространства и мобильных устройств, предлагающих широкий выбор образовательных ресурсов. Целью, проведенного исследования, является выявление особенностей при разработке учебных материалов с применением технологии реверсивного обучения, а также разработка рекомендаций по применению технологии в рамках образовательного процесса. Автором статьи были проанализированы формы и методы организации учебных занятий. Определено содержание учебно-методических рекомендаций. Обоснована необходимость использования технологии реверсивного обучения на практике. Рассмотрены теоретические основы и предпосылки возникновения технологии. В результате анализа и обобщения теоретического материала, выявлены особенности при разработке учебных материалов с применением технологии, разработаны рекомендации по применению технологии в рамках образовательного процесса, а также доказано, что применение технологии реверсивного обучения является эффективным, так как технология способствует повышению успеваемости и интереса учащихся к учебному процессу.Цель. Статья посвящена исследованию образовательной технологии реверсивного обучения и применению ее на практике в рамках образовательного процесса. Предметом анализа выступают особенности разработки учебных материалов при применении технологии реверсивного обучения. Автор ставит целью выявить особенности при разработке учебных материалов с применением технологии и разработать рекомендации по применению технологии в рамках образовательного процесса.Метод и методология проведения работы. Основу исследования образуют метод анализа, метод синтеза и обобщения теоретического материала.Результаты. Результаты работы заключаются в том, что автор выявляет особенности при разработке учебных материалов при применении технологии реверсивного обучения, разрабатывает рекомендации по её использованию, при этом учитывая плюсы и минусы технологии, которые необходимо принимать во внимание при внедрении технологии в учебный процесс.Область применения результатов. Результаты исследования могут быть применены при изучении педагогики, теории и практики преподавания иностранных языков и культур, а также в качестве рекомендации по применению технологии в рамках образовательного процесса.