bluuebunny/crossref_metadata_2025_split huggingface dataset:
Four-year course of quality of life and obsessive–compulsive disorder
Authors: Remmerswaal Karin C. P. , Batelaan Neeltje M. , Hoogendoorn Adriaan W. , van der Wee Nic J. A. , van Oppen Patricia , van Balkom Anton J. L. M. 
Published: September 2019

Abstract

Objective
Patients with obsessive compulsive disorder (OCD) have high disease burden. It is important to restore quality of life (QoL) in treatment, so that patients become able to live a fulfilling life. Little is known about the longitudinal course of QoL in patients with OCD, its association with remission from OCD, and about factors that contribute to an unfavourable course of QoL in remitting patients.

Methods
Study on the 4-year course of QoL of patients with chronic (n = 144), intermittent (n = 22), and remitting OCD (n = 73) using longitudinal data of the Netherlands Obsessive Compulsive Disorder Association (NOCDA; complete data: n = 239; imputed data n = 382). The EuroQol five-dimensional questionnaire (EQ-5D) utility score was used to assess QoL. In patients with remitting OCD, we examined patient characteristics that contributed to an unfavourable course of QoL, including sociodemographics, OCD characteristics, psychiatric comorbidity, and personality traits.

Results
Course of QoL was associated with course of OCD. QoL improved in those who remitted from OCD; however, even in these patients, QoL remained significantly below the population norms. The correlation between QoL and severity of OCD was only moderate: r = − 0.40 indicating that other factors besides OCD severity contribute to QoL. In remitters, more severe anxiety and depression symptoms were related to a lower QoL. Results were similar in complete and imputed data sets.

Conclusions
Remission from OCD is associated with improvement of QoL, but comorbid anxiety and depression symptoms hamper the improvement of QoL. QoL could be improved by reducing OCD symptoms in patients with OCD and by treating comorbid anxiety and depression symptoms in remitting patients.
Adult-onset Still’s disease with macrophage activation syndrome diagnosed and treated based on cytokine profiling: a case-based review
Authors: Goda Ken , Kenzaka Tsuneaki , Hoshijima Masahiko , Yachie Akihiro , Akita Hozuka 
Published: September 2019

Abstract
Adult-onset Still’s disease (AOSD) is a relatively rare systemic inflammatory disorder and is diagnosed using various sets of classification criteria, with the Yamaguchi criteria as the most widely used criteria. Herein, we present the case of a 21-year-old woman admitted with a high fever, lasting for over 1 month, who did not fulfill the Yamaguchi criteria. However, by analyzing the inflammatory cytokine profile, we defined this case as AOSD based on a greatly elevated serum interleukin-18 level. In addition, we predicted the occurrence of macrophage activation syndrome by a characteristic increase in the soluble tumor necrosis factor receptor II level, which allowed a timely intervention for this malicious complication. Therefore, we suggest that cytokine profiling will be useful for the diagnosis and management of AOSD.
Analysis of early-flowering genes at barley chromosome 2H expands the repertoire of mutant alleles at the Mat-c locus
Authors: Matyszczak Izabela , Tominska Marta , Zakhrabekova Shakhira , Dockter Christoph , Hansson Mats 
Published: September 2019

AbstractKey messageAnalyses of barleymat-closs of function mutants reveal deletions, splice-site mutations and nonsynonymous substitutions in a key gene regulating early flowering.AbstractOptimal timing of flowering is critical for reproductive success and crop yield improvement. Several major quantitative trait loci for flowering time variation have been identified in barley. In the present study, we analyzed two near-isogenic lines, BW507 and BW508, which were reported to carry two independent early-flowering mutant loci,mat-b.7andmat-c.19, respectively. Both introgression segments are co-localized in the pericentromeric region of chromosome 2H. We mapped the mutation in BW507 to a 31 Mbp interval on chromosome 2HL and concluded that BW507 has a deletion ofMat-c, which is an ortholog ofAntirrhinum majus CENTRORADIALIS(AmCEN) andArabidopsis thaliana TERMINAL FLOWER1(AtTFL1). Contrary to previous reports, our data showed that both BW507 and BW508 areMat-cdeficient and none of them aremat-b.7derived. This work complements previous studies by identifying the uncharacterizedmat-c.19mutant and seven additionalmat-cmutants. Moreover, we explored the X-ray structure of AtTFL1 for prediction of the functional effects of nonsynonymous substitutions caused by mutations inMat-c.
Association of regenerating gene 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma susceptibility in southern Chinese population
Authors: Xing Haijie , Chen Xiangdong , Sun Hongxia , Han Yaofeng , Ding Lanshu , Chen Xiaoxia 
Published: September 2019

Abstract

Objective
Nasopharyngeal carcinoma (NPC) is a common malignancy in Southern China and Southeast Asia. Genetic susceptibility is a major contributing factor in determining the individual risk of NPC in these areas. To test the association between NPC and variants in regenerating gene 1A (REG1A), we conducted a hospital-based case–control study in a Cantonese-speaking population from Guangdong province.

Methods
We endeavored to determine whether genetic variants of the REG1A gene were associated with the risk of NPC amidst the Cantonese population in a hospital-based case–control study using polymerase chain reaction-restriction and direct sequencing analysis in 211 NPC patients and 150 healthy controls. The association between NPC risk and the 14C/T, 20C/T, 369G/T, 1201A/G, and 2922C/T polymorphisms was examined after adjustment for age and sex.

Results
We found an increased risk of developing NPC in individuals with REG1A 2922C/T variant genotype (p = 0.003, OR 0.419, 95% CI 0.235–0.746), and after adjustment for sex and age (p = 0.003, OR 0.406, 95% CI 0.226–0.732). No association between other polymorphisms (14C/T, 20C/T, 369G/T, and 1201A/G) and the risk of NPC was observed, before or after adjustment for age and sex.

Conclusion
Our findings suggest that the REG1A 2922C/T polymorphism is associated with an increased risk of developing NPC in a Cantonese population from Guangdong province. Larger studies are required to confirm our findings and unravel the underlying mechanisms.
Phantom design and dosimetric characterization for multiple simultaneous cell irradiations with active pencil beam scanning
Authors: Clausen Monika , Khachonkham Suphalak , Gruber Sylvia , Kuess Peter , Seemann Rolf , Knäusl Barbara , Mara Elisabeth , Palmans Hugo , Dörr Wolfgang , Georg Dietmar 
Published: September 2019

Abstract
A new phantom was designed for in vitro studies on cell lines in horizontal particle beams. The phantom enables simultaneous irradiation at multiple positions along the beam path. The main purpose of this study was the detailed dosimetric characterization of the phantom which consists of various heterogeneous structures. The dosimetric measurements described here were performed under non-reference conditions. The experiment involved a CT scan of the phantom, dose calculations performed with the treatment planning system (TPS) RayStation employing both the Pencil Beam (PB) and Monte Carlo (MC) algorithms, and proton beam delivery. Two treatment plans reflecting the typical target location for head and neck cancer and prostate cancer treatment were created. Absorbed dose to water and dose homogeneity were experimentally assessed within the phantom along the Bragg curve with ionization chambers (ICs) and EBT3 films. LETd distributions were obtained from the TPS. Measured depth dose distributions were in good agreement with the Monte Carlo-based TPS data. Absorbed dose calculated with the PB algorithm was 4% higher than the absorbed dose measured with ICs at the deepest measurement point along the spread-out Bragg peak. Results of experiments using melanoma (SKMel) cell line are also presented. The study suggested a pronounced correlation between the relative biological effectiveness (RBE) and LETd, where higher LETd leads to elevated cell death and cell inactivation. Obtained RBE values ranged from 1.4 to 1.8 at the survival level of 10% (RBE10). It is concluded that dosimetric characterization of a phantom before its use for RBE experiments is essential, since a high dosimetric accuracy contributes to reliable RBE data and allows for a clearer differentiation between physical and biological uncertainties.
Meta-analysis of haematoma volume, haematoma expansion and mortality in intracerebral haemorrhage associated with oral anticoagulant use
Authors: Seiffge David J. , Goeldlin Martina B. , Tatlisumak Turgut , Lyrer Philippe , Fischer Urs , Engelter Stefan T. , Werring David J. 
Published: September 2019

AbstractObjectiveTo obtain precise estimates of age, haematoma volume, secondary haematoma expansion (HE) and mortality for patients with intracerebral haemorrhage (ICH) taking oral anticoagulants [Vitamin K antagonists (VKA-ICH) or non-Vitamin K antagonist oral anticoagulants (NOAC-ICH)] and those not taking oral anticoagulants (non-OAC ICH) at ICH symptom onset.MethodsWe conducted a systematic review and meta-analysis of studies comparing VKA-ICH or NOAC-ICH or both with non-OAC ICH. Primary outcomes were haematoma volume (in ml), HE, and mortality (in-hospital and 3-month). We calculated odds ratios (ORs) using the Mantel–Haenszel random-effects method and corresponding 95% confidence intervals (95%CI) and determined the mean ICH volume difference.ResultsWe identified 19 studies including data from 16,546 patients with VKA-ICH and 128,561 patients with non-OAC ICH. Only 2 studies reported data on 4943 patients with NOAC-ICH. Patients with VKA-ICH were significantly older than patients with non-OAC ICH (mean age difference: 5.55 years, 95%CI 4.03–7.07,p < 0.0001,I2 = 92%,p < 0.001). Haematoma volume was significantly larger in VKA-ICH with a mean difference of 9.66 ml (95%CI 6.24–13.07 ml,p < 0.00001;I2 = 42%,p = 0.05). HE occurred significantly more often in VKA-ICH (OR 2.96, 95%CI 1.74–4.97,p < 0.00001;I2 = 65%). VKA-ICH was associated with significantly higher in-hospital mortality (VKA-ICH: 32.8% vs. non-OAC ICH: 22.4%; OR 1.83, 95%CI 1.61–2.07,p < 0.00001,I2 = 20%,p = 0.27) and 3-month mortality (VKA-ICH: 47.1% vs. non-OAC ICH: 25.5%; OR 2.24, 95%CI 1.52–3.31,p < 0.00001,I2 = 71%,p = 0.001). We did not find sufficient data for a meta-analysis comparing NOAC-ICH and non-OAC-ICH.ConclusionThis meta-analysis confirms, refines and expands findings from prior studies. We provide precise estimates of key prognostic factors and outcomes for VKA-ICH, which has larger haematoma volume, increased rate of HE and higher mortality compared to non-OAC ICH. There are insufficient data on NOACs.
Unexpected emergence from the vegetative state: delayed discovery rather than late recovery of consciousness
Authors: van Erp Willemijn S. , Aben Anoek M. L. , Lavrijsen Jan C. M. , Vos Pieter E. , Laureys Steven , Koopmans Raymond T. C. M. 
Published: September 2019

Abstract

Background
The vegetative state, also known as the unresponsive wakefulness syndrome, is one of the worst possible outcomes of acquired brain injury and confronts rehabilitation specialists with various challenges. Emergence to (minimal) consciousness is classically considered unlikely beyond 3–6 months after non-traumatic or 12 months after traumatic etiologies. A growing body of evidence suggests that these timeframes are too narrow, but evidence regarding chances of recovery is still limited.

Objective
To identify the moment of recovery of consciousness in documented cases of late emergence from a vegetative state.

Methods
Four cases of apparent late recovery of consciousness, identified within a prospective cohort study, were studied in-depth by analyzing medical, paramedical and nursing files and interviewing the patients’ families about their account of the process of recovery.

Results
All patients were found to have shown signs of consciousness well within the expected time frame (5 weeks–2 months post-ictus). These behaviors, however, went unnoticed or were misinterpreted, leading to a diagnostic delay of several months to over 5 years. Absence of appropriate diagnostics, the use of erroneous terminology, sedative medication but also patient-related factors such as hydrocephalus, language barriers and performance fluctuations are hypothesized to have contributed to the delay.

Conclusions
Delayed recognition of signs of consciousness in patients in a vegetative state may not only lead to suboptimal clinical care, but also to distorted prognostic figures. Discriminating late recovery from the delayed discovery of consciousness, therefore, is vital to both clinical practice and science.
A review of friction damping modeling and testing
Authors: Gagnon Louis , Morandini Marco , Ghiringhelli Gian Luca 
Published: September 2019

Abstract
This survey provides an insight into the modeling and testing of uniaxial friction dampers. The focus is on attenuating the linear relative movement along planar surfaces for frequencies between 10 Hz and 1 kHz. An overview of the different approaches seen in the literature concerning friction damping is provided. Examples and evaluation of such dampers excited over a wide range of frequencies are presented. The information required to develop models of friction dampers is covered. To that end, different modeling approaches are presented for dry friction. Dynamic friction models with an internal state are covered, and their advantages are described. Other modeling approaches are reported for complete systems with friction dampers. Both numerical and analytical models are covered. Experimental configurations from a selection of authors are also included. Finally, a series of suggestions for the numerical modeling and experimental testing of a friction damper are given.
Compound danshen dripping pills normalize a reprogrammed metabolism of myocardial ischemia rats to interpret its time-dependent efficacy in clinic trials: a metabolomic study
Authors: Aa Nan , Guo Jia-Hua , Cao Bei , Sun Run-Bin , Ma Xiao-Hui , Chu Yang , Zhou Shui-Ping , Aa Ji-Ye , Yang Zhi-Jian , Sun He , Wang Guang-Ji 
Published: September 2019

Abstract

Introduction
Clinical trials of Compound danshen dripping pills (CDDP) indicated distinct improvement in patients with chronic stable angina. Daily fluctuation of therapeutic effect agreed with a peak-valley PK profile during a 4-week CDDP regimen, but stabilized after 8-week treatment.

Objectives
This article aims to explore the underlying mechanism for the time-dependent drug efficacy of the up-down fluctuation or stabilization in clinic trials.

Methods
A rat model of myocardial ischemia was established via isoproterenol induction. Metabolomics was employed to analyze the energy-related substances both in circulatory system and myocardium in the myocardial ischemia model.

Results
CDDP treatment ameliorated myocardial ischemia, reversed the reprogramming of the metabolism induced by ISO and normalized the level of most myocardial substrates and the genes/enzymes associated with those metabolic changes. After 1- or 2-week treatment, CDDP regulated plasma and myocardial metabolome in an analogous, time-dependent way, and modulated metabolic patterns of ischemic rats that perfectly matched with the fluctuated or stabilized effects observed in clinical trials with 4 or 8-week treatment, respectively.

Conclusion
Metabolic modulation by CDDP contributes to the fluctuated or stabilized therapeutic outcome, and is a potential therapeutic approach for myocardial ischemia diseases.
Finding indications of lag time, saturation and trading inflow in the emergence record of exotic agricultural insect pests in Japan
Authors: Morimoto Nobuo , Kiritani Keizi , Yamamura Kohji , Yamanaka Takehiko 
Published: September 2019

Abstract
Agricultural imports are the primary pathway for the introduction of exotic insect pests. The invasion records of exotic insect pests are also influenced by the lag time before detection and saturation caused by the limited species pool of potential invaders. We compiled an exhaustive list of exotic insect species in mainland Japan and tried to evaluate the connection between the commodity types of agricultural imports and insect types of agricultural pests, in addition to the effects of lag time and saturation. We found that lag time was prominent when all pest types were merged into one group, whilst saturation always existed when we divided the records into the four agricultural pest types. Saturation was especially prominent in stored product pests because this group contained many cosmopolitan insect pests that could have easily inhabited the newly built mills throughout Japan in the 1950s. We suspect that the saturation effect was masked by admixture amongst pests with different saturation patterns. Our findings indicate that all commodities, i.e. flowers, fruits, vegetables, cereal and timber, contributed to the invasion of pest insects as potential pathways. However, it was unclear if certain items had comparatively greater significance in this process.
Scheduling of undergraduate thesis examination: a case study in Industrial Engineering Department of Universitas Sebelas Maret
Authors: Rosyidi Cucuk Nur , Budiningsih Endah , Jauhari Wakhid Ahmad 
Published: September 2019

Abstract
Undergraduate thesis examination in Industrial Engineering Department of Universitas Sebelas Maret conducted through two stages, namely intermediate and final examination. Currently, the scheduling process of such examinations is done by the undergraduate thesis coordinator manually without certain systematic method or approach. In this paper, we develop an optimization model for the examinations scheduling considering several factors, namely the number of lecturers that must attend the examinations, the availability of rooms for examinations, the availability of each lecturer, and the assignment distributions. The model uses integer programming approach. Two performance criteria are used in the model, namely the difference between the number of each lecturer’s assignment with the average number of lecturer assignments and the number of penalties from the assignment of lecturers on certain time slot. The developed model is able to solve the scheduling problem more efficiently than manual scheduling done by thesis coordinator. The optimal solutions from the optimization model show a total difference in the assignment of lecturer with an average of 29.6 and a penalty of 0.
Umbilical Cord Abnormalities and Pregnancy Outcome
Authors: Elsayed Waleed , Sinha Anita 
Published: September 2019

AbstractUmbilical cord anomalies can be related to its morphology (coiling, length and thickness); placental insertion (marginal and velamentous insertion); in utero distortion (knotting, torsion and nuchal cord) vascular abnormalities (single umbilical artery) and primary tumours or masses (haemangioma and teratoma). Some of these conditions may be associated with other foetal abnormalities or aneuploidy. On the other hand, several prenatal complications including intrauterine growth restriction IUGR and stillbirth can be attributed to cord accidents or abnormalities. Early detection and close follow up of umbilical cord abnormalities can reduce the risk of morbidity and mortality and assist in decision making. To understand the normal development of the umbilical cord and discuss several pathologic processes which are involved in different cord abnormalities.
The rise of renewables and energy transition: what adaptation strategy exists for oil companies and oil-exporting countries?
Authors: Fattouh Bassam , Poudineh Rahmatallah , West Rob 
Published: September 2019

AbstractThe energy landscape is changing rapidly with far-reaching implications for the global energy industry and actors, including oil companies and oil-exporting countries. These rapid changes introduce multidimensional uncertainty, the most important of which is the speed of the transition. While the transformation of the energy system is rapid in certain regions of the world, such as Europe, the speed of the global energy transition remains highly uncertain. It is also difficult to define the end game (which technology will win and what the final energy mix will be), as the outcome of transition is likely to vary across regions. In this context, oil companies are facing a strategic dilemma: attempt the risky transition to low-carbon technologies by moving beyond their core business or just focus on maximising their return from their hydrocarbon assets. We argue that, due to the high uncertainty, oil companies need to develop strategies that are likely to be successful under a wide set of possible future market conditions. Furthermore, the designed strategies need to be flexible and evolve quickly in response to anticipated changes in the market. For oil-exporting countries, there is no trade-off involved in renewable deployment as such investments can liberate oil and gas for export markets, improving the economics of domestic renewables projects. In the long run, however, the main challenge for many oil countries is economic and income diversification as this represents the ultimate safeguard against the energy transition. Whether or not these countries succeed in their goal of achieving a diversified economy and revenue base has implications for investment in the oil sector and oil prices and consequently for the speed of the global energy transition.
Martha Kneale on Why Metaphysical Necessities Are NotA Priori
Authors: LEECH JESSICA 
Published: September 2019

AbstractIn her 1938 paper ‘Logical and Metaphysical Necessity’, Martha Kneale introduces the necessarya posteriori. I present a critical summary of Kneale's argument that so-called ‘metaphysical propositions’ are necessary but nota priori. I argue that Kneale is well placed to offer a template for reconciling conceivability approaches to modal epistemology with the post-Kripkean trend for taking metaphysical necessities to have their source in mind-independent reality.
#RhodesMustFall: How a Decolonial Student Movement in the Global South Inspired Epistemic Disobedience at the University of Oxford
Authors: Ahmed A. Kayum 
Published: September 2019

Abstract:When the #RhodesMustFall (#RMF) movement erupted at the University of Cape Town (UCT) in March 2015, it not only sparked the proliferation of student movements across South Africa, but also led to the formation of #RMF at the University of Oxford and similar movements at universities in the United States. By drawing on ninety-eight interviews with various actors involved in both movements, Ahmed’s empirical research contributes to the limited academic literature on the connections between the #RMF movements in Cape Town and in Oxford. The example of the #RMF movement in Cape Town inspired the #RMF Oxford movement to challenge the epistemic architecture of the University of Oxford.