bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Economics of Financial Stress
Authors: Sergeyev Dmitriy , Lian Chen , Gorodnichenko Yuriy 
Published: November 2024

Abstract
We study the psychological costs of financial constraints and their economic consequences. Using a representative survey of U.S. households, we document the prevalence of financial stress in U.S. households and a strong relationship between financial stress and measures of financial constraints. We incorporate financial stress into an otherwise standard dynamic model of consumption and labour supply. We emphasize two key results. First, both financial stress itself and naivete about financial stress are important components of a psychology-based theory of the poverty trap. Sophisticated households, instead, save extra to escape high-stress states because they understand that doing so alleviates the economic consequences of financial stress. Second, the financial stress channel dampens or reverses the counterfactual large negative wealth effect on labour earnings because relieving stress frees up cognitive resources for productive work. Financial stress also has macroeconomic implications for wealth inequality and fiscal multipliers.
Measuring energy expenditure in narcolepsy using doubly labeled water and respiration chamber calorimetry
Authors: Donjacour Claire E H M , Gool Jari K , Schoffelen Paul F , Wouters Loek , Overeem Sebastiaan , Lammers Gert Jan , Pijl Hanno , Westerterp Klaas R 
Published: November 2024

Abstract

Study Objectives
Hypocretin deficiency causes type 1 narcolepsy, a condition characterized by excessive daytime sleepiness, cataplexy, and fragmented nocturnal sleep. Two-thirds of people with narcolepsy are also overweight, of which half are obese. The pathophysiology behind weight gain in people with narcolepsy remains unknown. We assessed a possible decrease in energy expenditure as a cause for overweight in narcolepsy using respiration chamber calorimetry and doubly labeled water.

Methods
Ten males with type I narcolepsy and nine matched (for age, sex, and BMI) healthy controls were enrolled. Participants stayed in a respiration chamber for 24 hours. They subsequently received doubly labeled water and wore an accelerometer for 2 weeks to assess energy expenditure and physical activity under daily living conditions. Total daily energy expenditure, resting energy expenditure (REE), overnight metabolic rate, physical activity level, and activity-induced energy expenditure were measured.

Results
No significant differences were found in REE, mean 24-hour respiration chamber energy expenditure, overnight metabolic rate, and activity-induced energy expenditure when comparing people with narcolepsy type 1 to controls. Physical activity was also comparable between groups.

Conclusions
Energy expenditure in narcolepsy type 1 is similar to matched controls, suggesting comparable metabolism and physical activity rates. It remains possible that metabolic changes are most pronounced around disease onset. In addition, patients had to discontinue their medication which may have influenced the results. Still, our findings suggest that other factors may also play a role in weight gain in narcolepsy, such as differences in dietary behavior.
Tensions, Challenges, and Opportunities: Internal Networks Supporting Gender Equality Policy Processes and Structural Change in Universities
Authors: Tildesley Rebecca , Bustelo María 
Published: November 2024

Abstract
This article examines the role of internal networks in supporting gender equality (GE) units and GE policy processes within universities, focusing on the tensions, challenges, and opportunities that can be encountered. Using two illustrative cases from Spain and employing a qualitative approach, it explores how these networks, bridging top-down and bottom-up approaches, navigate the balance between centralized and decentralized approaches in managing and implementing GE plans and the impact of institutionalization. Research has examined GE policy networks and women’s academic participation, but within-university GE networks are less studied. Tensions arise between institutionalization and feminist activism, coordinated action and idea generation, and local ownership and change agents’ limited authority. Challenges include obtaining institutional recognition while maintaining feminist sensibility, emphasizing the importance of nurturing networks. We highlight the productive power of resistance and the need to capitalize on context-specific opportunities for driving structural change in universities.
Cold plasma for enhanced water purification
Authors: Maybin Jordanne-Amee , McClenaghan Laura A , Gilmore Brendan F , Thompson Thomas P 
Published: November 2024

Abstract
Access to clean water remains a critical global challenge, with traditional water treatment methods often failing to eliminate complex pollutants such as pharmaceuticals, dyes, and antibiotics. Cold atmospheric plasma technology offers a promising solution by generating reactive oxygen and nitrogen species at room temperature, effectively degrading these contaminants and inactivating pathogens. Recent advancements in cold plasma have shown significant potential in water treatment applications. Cold plasma has demonstrated efficacy in disrupting bacterial biofilms, reducing antibiotic contaminants, and degrading complex organic pollutants, making it an innovative and eco-friendly alternative to conventional methods. This review examines the principles of plasma technology, evaluates its performance in water sanitation, and addresses the challenges of scalability and economic feasibility. By integrating cold plasma into existing water treatment systems and developing standardized protocols, this technology can significantly contribute to sustainable water management and public health, supporting the Sustainable Development Goals.
The Effect of Shortening High-School Duration by One Year on Student Outcomes: Evidence from Ghana
Authors: Denteh Augustine , Asare Samuel , Senadza Bernardin 
Published: November 2024

Abstract
In 2010, the government of Ghana shortened the duration of senior high school by one year. As a result of this policy, the 2009 and 2010 high-school entry cohorts experienced exogenously different years of education but took the same exit exam in 2013. Using nationwide administrative data on the two cohorts, we find that the one-year reduction in schooling substantially worsened performance in all subjects. The most economically significant declines occurred in two core subjects with the lowest historical pass rates—core mathematics and integrated science. Analysis by gender shows larger detrimental effects for female students in science, technology, engineering, and mathematics subjects. We also find suggestive evidence that the policy negatively impacted students in the long term.
Time‐series transcriptomics reveals distinctive mRNA expression dynamics associated with gene ontology specificity and protein expression in skeletal muscle after electrical stimulation‐induced resistance exercise
Authors: Kusano Tatsuya , Sotani Yuta , Takeda Reo , Hatano Atsushi , Kawata Kentaro , Kano Ryotaro , Matsumoto Masaki , Kano Yutaka , Hoshino Daisuke 
Published: November 2024

AbstractResistance exercise upregulates and downregulates the expression of a wide range of genes in skeletal muscle. However, detailed analysis of mRNA dynamics such as response rates and temporal patterns of the transcriptome after resistance exercise has not been performed. We aimed to clarify the dynamics of time‐series transcriptomics after resistance exercise. We used electrical stimulation‐induced muscle contraction as a resistance exercise model (5 sets × 10 times of 3 s of 100‐Hz electrical stimulation) on the tibialis anterior muscle of rats and measured the transcriptome in the muscle before and at 0, 1, 3, 6, and 12 h after muscle contractions by RNA sequencing. We also examined the relationship between the parameters of mRNA dynamics and the increase in protein expression at 12 h after muscle contractions. We found that the function of the upregulated genes differed after muscle contractions depending on their response rate. Genes related to muscle differentiation and response to mechanical stimulus were enriched in the sustainedly upregulated genes. Furthermore, there was a positive correlation between the magnitude of upregulated mRNA expression and the corresponding protein expression level at 12 h after muscle contractions. Although it has been theoretically suggested, this study experimentally demonstrated that the magnitude of the mRNA response after electrical stimulation‐induced resistance exercise contributes to skeletal muscle adaptation via increases in protein expression. These findings suggest that mRNA expression dynamics such as response rate, a sustained upregulated expression pattern, and the magnitude of the response contribute to mechanisms underlying adaptation to resistance exercise.
When Leaders Don’t Walk the Walk: A National Survey of Academic Nurse Leader Perceptions of Staff Burnout
Authors: Martinez-Hollingsworth Adrienne , Goodolf Dawn , Martin Nia , Kim Linda , Saylor Jennifer , Evans Jennifer , Hines Annette , Jun Jin 
Published: November 2024

Abstract

AIM
This survey explored nurse leaders’ impressions of burnout on college/school of nursing (CON/SON) administrative staff and leadership-facilitated strategies used to promote resilience building/mitigate burnout.

BACKGROUND
Administrative staff are foundational to the success of a university’s CON/SON, yet few studies have explored the impact of burnout in this group.

METHOD
Cross-sectional survey distributed to associate dean and business officer attendees of the 2022 American Association of Colleges of Nursing, Business Officers of Nursing Schools meeting (summer 2022) (n = 64).

RESULTS
Most respondents lacked a burnout mitigation plan (46/64, 72%); many also lacked a personal strategy for managing their own burnout (46/64, 72%) and did not personally participate in university activities to maintain their well-being (45/64, 70%).

CONCLUSION
This study highlights the impact of nurse leaders who fail to model self-care, which may limit the benefit of costly burnout mitigation activities and resources in their universities.
Efficacy and safety of immune checkpoint inhibitors in the treatment of recurrent or metastatic nasopharyngeal carcinoma: A systematic review and meta-analysis
Authors: Yu Zhixin , Hong Shaodong , Yu Hui , Zhang Xuanye , Li Zichun , Chen Ping , Zhou Yixin 
Published: November 2024

Abstract

Background:
The combination of immune checkpoint inhibitors and chemotherapy (ICI + Chemo) shows promise in recurrent or metastatic nasopharyngeal carcinoma (RM-NPC), but some patients experience limited benefit and survival predictors remain unclear. Furthermore, ICIs efficacy in subsequent treatments needs further evaluation.

Methods:
A systematic search of PubMed, Embase, the Cochrane Library, and major conference proceedings was conducted to identify studies for meta-analysis. The objective was to compare ICI + Chemo with chemotherapy in first-line treatment and identify efficacy predictors, and to evaluate ICIs alone in subsequent-line treatment for RM-NPC, with a focus on progression-free survival (PFS), objective response rate (ORR), and treatment-related adverse events (AEs).

Results:
Fifteen trials involving 1928 patients were included. Three trials compared ICI + Chemo with chemotherapy as a first-line treatment, while 12 trials evaluated ICIs alone in subsequent-line treatment of RM-NPC patients. First-line ICI + Chemo showed superior PFS (hazard ratio [HR] = 0.52, 95% confidence interval [CI], 0.43–0.63; P <0.001) and ORR (risk ratio [RR] = 1.14, 95% CI, 1.05–1.24; P <0.001) compared to chemotherapy, without increased AEs (RR = 1.01, 95% CI, 0.99–1.03; P = 0.481). Neither programmed death-ligand 1 (PD-L1) nor other factors predicted the efficacy of ICI + Chemo vs. chemotherapy. Subsequent-line ICIs alone had a median PFS of 4.12 months (95% CI, 2.93–5.31 months), an ORR of 24% (95% CI, 20–28%), with grade 1–5/grade 3–5 AEs at 79%/14%. However, ICIs alone were associated with significantly shorter PFS (HR = 1.31, 95% CI, 1.01–1.68; P = 0.040) than chemotherapy alone.

Conclusions:
ICI + Chemo confers superior survival benefits compared to chemotherapy in first-line RM-NPC treatment, independent of PD-L1 expression or other factors. However, ICIs alone demonstrate a manageable safety profile but do not surpass chemotherapy in efficacy for subsequent-line treatment.
Cosmic Radiation Exposure: A Review of Recent Research on the Incidence and Prevention of Cancer in Aircrews
Authors: Eckhardt Lisa D. 
Published: November 2024

Abstract
The author provides a literature review examining the clinical risks of cosmic radiation exposure and incidence of cancer in aircrews including pilots, flight attendants, and flight engineers or navigators. The review focuses on ionizing radiation exposure in aircrews as an occupational working group. The author will discuss the types of cancer associated with cosmic ionizing radiation exposure and the prevalence of certain cancer types noted in this population. Monitoring of ionizing radiation of aircrews in the United States is not required in 2024, which makes assessing exposure a challenge. The author also discusses associated risk factors and prevention strategies in aircrews. United States aircrews are an occupational group with known elevated exposure to ionizing radiation from natural cosmic sources, which has been linked to health risks, particularly for cancer. This occupational group is not monitored in 2024 and would benefit from occupational exams for medical surveillance and hazard awareness.
Orbicularis Oculi Transpalpebral Pedicle Flap for the Repair of Laminar Resorption Associated With Osteo-Odonto-Keratoprosthesis
Authors: Hong Sheng Chiong , Trinh Tanya , Martin Peter , Chorny Alexander , Moloney Greg 
Published: November 2024

Abstract:
Osteo-odonto-keratoprosthesis (OOKP) is a surgical procedure reserved for severe end-stage corneal blindness with a dry, keratinized ocular surface. Late resorption of bone has been described as a complication of this procedure. We present a novel surgical technique to repair laminar resorption associated with OOKP using transpalpebral split-pedicle orbicularis oculi flaps. The technique comes with the advantages of not needing additional bone grafts, and provides the alveo-bonemucosa complex with additional tissue bulk and blood supply.
Intraoperative liquid biopsy as a tool for detecting R1 resection during pancreatoduodenectomy in patients with pancreatic carcinoma: the CETUPANC trial (part II)
Authors: Padillo-Ruiz Javier , Garcia Carlos , Suarez Gonzalo , Blanco Gerardo , Muñoz-Bellvis Luis , Justo Iago , García-Domingo Maria I. , Ausania Fabio , Muñoz-Forner Elena , Serrablo Alejandro , Martin Elena , Díez Luis , Cepeda Carmen , Marin Luis , Alamo Jose , Bernal Carmen , Pereira Sheila , Calero Francisco , Laga Imán , Paterna Sandra , Cugat Esteban , Fondevila Constantino , López-Guerra Diego , Gallego-Jiménez Inmaculada , Borrero-Martín Juan José , Gomez-Bravo Miguel Ángel , Tinoco Jose , Sabater Luis 
Published: November 2024

Introduction:
A positive surgical margin (R1 resection) is a relevant risk factor for local recurrence in patients with pancreatic ductal adenocarcinoma of the pancreas (PDAC). An intraoperative liquid biopsy (ILB) based on tumor cell mobilization could help to detect R1 resection intraoperatively.

Objective:
To evaluate the potential role of the intraoperative circulating tumor cells (CTCs) and cluster mobilization on the R0/R1 detection.

Methods:
Sixty-three patients with resectable PDAC of the head of the pancreas were prospective enrolled under the CETUPANC trial. Open pancreaticoduodenectomy (PD) was done in all patients. Intraoperative CTCs and clusters were determined during PD.

Results:
The overall rate of R1 resection was 34.9% (22/63 patients). Multivariate analysis showed that factors associated with R1 resection (AUC=0.920) were the presence of undifferentiated G3 tumor (P=0.017), microscopic vascular invasion (P=0.016), and the intraoperative increase of both free CTCs and clusters in portal vein determination from the beginning to the end of the surgery (P=0.002 and P=0.005, respectively). A specific logistic regression model, including delta end to baseline CTCs and cluster mobilization to achieve a combined cut-off to detect R1 detection was calculated (AUC=0.799). The obtained R1-index based on ILB had 84% of sensitivity and 68% of specificity to detect R1 resection.

Conclusions:
The ILB based on the intraoperative mobilization of CTCs and clusters from the beginning to the end of the PD was a predictive factor to detect R1 resection in patients with PDAC.
The Difficulties of Treating Complement-3–Mediated Glomerulopathy
Authors: Ghani Maham , Alisan Bedir , Barmas-Alamdari Daniel , Attieh Rose Mary , Jhaveri Kenar D. 
Published: November 2024

Background:
C3 glomerulopathy (C3G) is a rare disease affecting the complement alternative pathway, categorized into dense deposit disease and C3 glomerulonephritis. Dense deposit disease predominantly affects younger individuals, while C3 glomerulonephritis tends to manifest in older populations. The diseases are characterized by dysregulation of the complement alternative pathway, leading to the deposition of complement components in the glomeruli and subsequent renal dysfunction. Notably, the incidence of C3G in the United States is low, with 1–3 cases per 1,000,000 and a prevalence of 5 cases per 1,000,000.

Areas of Uncertainty:
Numerous uncertainties persist in comprehending the etiology and pathophysiology of C3G. While biomarkers such as C3 nephritic factor, autoantibodies, and relevant genetic mutations have been identified, their pathogenicity and clinical utility remain unclear. Standard workups involve complement assays and autoantibody panels, yet the definitive diagnostic test remains a kidney biopsy. Nuanced challenges lie in deciphering the sensitivity and specificity of these diagnostic tools, especially in the presence of phenotypical variations among individuals.

Therapeutic Advancement:
Current therapeutic approaches, albeit lacking robust evidence, encompass a spectrum ranging from supportive care to targeted B-cell therapy and immunosuppression with mycophenolate mofetil and glucocorticoids. For severe and refractory cases, the monoclonal antibody eculizumab, targeting C5 in the complement cascade, is recommended. These treatments, while offering some relief, pose challenges related to their cost and obtaining insurance approval. Exploratory avenues delve into the potential of plasma exchange and innovative treatments such as oral complement inhibitors, reflecting the ongoing quest for effective therapeutic modalities. Trials investigating various complement inhibitors underscore the dynamic landscape of therapeutic advancements in C3G management.

Conclusion:
In conclusion, the article highlights the complexities of C3G management. The need for further understanding, large-scale trials, and ongoing investigations into disease etiology and pathophysiology is emphasized.
Correlation Between Self-reported or Supervised Physical Activity in Noncommunicable Diseases and Comorbidities During COVID-19 Pandemic: A Systematic Review
Authors: Dixit Snehil , Srivastava Saumya , Reddy Ravi Shankar , Faghy MA , Tedla Jaya Shanker , Kakaraparthi Venkata Nagaraj , Gular Kumar , Gupta Kanishk 
Published: November 2024

Abstract

Objective
The aim of the study is to systematically identify the protective and ameliorative effects of physical activity among people with noncommunicable diseases such as diabetes, cancer, chronic respiratory disease, chronic vascular disease, hypertension, and existing comorbidities during the coronavirus disease (COVID-19) pandemic.

Methods
The trial is registered in the PROSPERO registry and used the PICO (population, intervention, comparison, and outcomes) strategy to perform the search strategy. Assessors analyzed related studies in the MEDLINE, PROQUEST, PubMed, Cochrane Library, CINAHL, Embase, Google Scholar, Physiotherapy Evidence, and Science Direct databases between December 2022 and January 2023. Researchers independently conducted a quality assessment of each study using a predeveloped quality assessment tool adapted from established tools for quantitative studies.

Results
Eighteen trials were included (chronic vascular disease–7, diabetes–4, hypertension–1, cancer–3, and chronic respiratory disease–3). The total number of individuals included in the systematic review was 780,003, and the total with or without COVID-19 was 188,435. Qualitative rating by the Newcastle-Ottawa Score for cross-sectional and cohort studies and the Physiotherapy Evidence Database scale revealed fair to good evidence for physical activity as a tool to reduce complications.

Conclusions
There is evidence that exercise can protect people with noncommunicable diseases during the COVID-19 pandemic.
Registration: Registered with Prospero registry
Understanding the Preferred Learning Styles of Urogynecology Patients
Authors: Kunycky Christina , Bernard Adele , Willis-Gray Marcella , Geller Elizabeth J. 
Published: November 2024

Importance
Patient comprehension is paramount to treatment option counseling in urogynecology. This study investigates how patients prefer to receive information in a learning environment.

Objective
This study aimed to understand the learning preferences of patients presenting to a urogynecology clinic.

Methods
We conducted a cross-sectional survey study of patients presenting to an outpatient academic urogynecology clinic. The primary objective was to identify patient learning styles using the Visual, Aural, Read/write, Kinesthetic (VARK) Learning Style Questionnaire. Secondary objectives included determining predictive characteristics of learning styles such as age, race, education level, socioeconomic status, and the patient's self-identified learning style.

Results
Of 125 participants, most were multimodal (60%) preferring a combination of learning styles. Twenty percent of patients were categorized as kinesthetic learners, 10% reading/writing, 7% aural, and 2% visual. Forty-three percent correctly identified their learning styles, and an additional 26% partially identified their learning styles. When assessing predictors of learning style, visual and kinesthetic learners were younger. Aural learners had a higher proportion of Black and Latina representation. Visual and reading/writing learners all had at least some college education.

Conclusions
Among patients presenting to a urogynecology clinic, a range of learning preferences was identified, with the majority of patients having a preference for multimodal learning with the majority accurately identifying 1 or more modalities of their learning styles. Given the high rate of multimodal learning, health care providers should consider having multiple modalities in which information can be provided to urogynecology patients.