bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of lnc‐IL17RA‐11 with increased radiation sensitivity and improved prognosis of HPV‐positive HNSCC
Authors: Song Lianhao , Xie Huanhuan , Tong Fangjia , Yan Bingqing , Zhang Siwei , Fu Enhui , Jing Qingxu , Wei Lanlan 
Published: May 2019

AbstractHuman papillomavirus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a far better prognosis than HPV negative HNSCC. Recent studies suggest that long noncoding RNA (lncRNA) moieties may play a role in HPV associated differential HNSCC prognoses. In this study, we examined differential expression of lncRNAs in HPV+ vs HPV− HNSCC using The Cancer Genome Atlas database. LncRNAs were categorized based on expression level and survival analysis. A group of eight lncRNAs was identified in which altered expression was associated with both HPV infection and better prognosis. Subsequently, genes coexpressed with these lncRNAs in HNSCC cells were sorted into corresponding co‐expression modules. The lnc‐IL17RA‐11 coexpression module exhibited the greatest correlation with HPV infection and radiotherapy efficacy. We identified the lnc‐IL17RA‐11 transcription factor ER‐alpha as the most likely HPV infection associated factor promoting increased lnc‐IL17RA‐11 levels. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis revealed enrichment among lnc‐IL17RA‐11 co‐expressed genes for functions related to DNA replication and cell proliferation. These observations are consistent with a model in which HPV infection upregulates transcription factor ER‐alpha, which increases levels of lnc‐IL17RA‐11 and coexpressed genes that promote HNSCC cell sensitivity to radiotherapy, thereby improving disease prognosis.
Matrine promotes apoptosis in SW480 colorectal cancer cells via elevating MIEF1‐related mitochondrial division in a manner dependent on LATS2‐Hippo pathway
Authors: Zhang Yawei , Wang Meiping , Xu Xianfeng , Liu Yonghong , Xiao Chunhong 
Published: May 2019

AbstractMatrine, an alkaloid compound isolated from Sophora flavescens Ait, has been shown to exert cancer‐killing actions in a variety of tumors; however, its anticancer mechanism in colorectal cancer (CRC) is not clear. The goal of our study was to characterize the anticancer effects and molecular mechanisms of matrine in SW480 CRC cells in vitro. Matrine treatment reduced mitochondrial metabolic function and ATP levels, repressed mitochondrial membrane potential, evoked mitochondrial reactive oxygen species accumulation, and promoted cyt‐c‐related mitochondrial apoptosis activation. In addition, we found that matrine treatment activated mitochondrial fission through upregulating mitochondrial elongation factor 1 (MIEF1); silencing of MIEF1 prevented matrine‐mediated mitochondrial damage and reversed the decrease in SW480 cell viability. Moreover, matrine treatment affected MIEF1 expression via the large tumor suppressor‐2 (LATS2)‐Hippo axis, and LATS2 deficiency suppressed the anticancer actions exerted by matrine on SW480 cancer cells. In summary, we show for the first time that matrine inhibits SW480 cell survival by activating MIEF1‐related mitochondrial division via the LATS2‐Hippo pathway. These findings explain the anticancer mechanisms of matrine in CRC and also identify the LATS2‐MIEF1 signaling pathway as an effective target for the treatment of CRC.
MRI‐based risk factors of hepatocellular carcinoma in patients with chronic liver disease: A prospective observational study
Authors: Shimizu Tatsuya , Motosugi Utaroh , Komatsu Nobutoshi , Ichikawa Shintaro , Inoue Taisuke , Onishi Hiroshi , Enomoto Nobuyuki 
Published: May 2019

BackgroundMR‐based metrics, including hepatobiliary phase (HBP) hypointense nodules without arterial phase hyperenhancement (APHE), and liver stiffness as measured by MR elastography are useful markers to stratify the risk of hepatocellular carcinoma (HCC) development in chronic liver disease patients. However, prospective studies are needed to clarify their utility.PurposeTo perform a risk analysis of HCC development in chronic liver disease patients, with a focus on MR‐based biomarkers.Study TypeProspective.SubjectsConsecutive 110 cirrhotic patients (61 males, 49 females) without a history of HCC who matched the inclusion criteria.Field Strength/Sequence3T/3D gradient‐echo T1‐weighted images and MR elastography.AssessmentPatients underwent MRI for HCC screening and attended follow‐up appointments every 3 months. The primary endpoint was the development of hypervascular HCC. Patients were classified according to the presence of an HBP hypointense nodule without APHE (if present in the liver, the patient was classified in nonclean liver group; if absent, clean liver group), and stiffness value on MR elastography (soft liver, <4.0 kPa; stiff liver, ≥4.0 kPa) at the initial examination.Statistical TestsRisk factors were identified in univariate and multivariate Cox regression models. Incidence rates of HCC development were evaluated using the Kaplan–Meier method.ResultsPatients were classified into clean‐liver (n = 76) and nonclean‐liver groups (n = 34), and into soft‐liver (n = 53) and stiff‐liver groups (n = 45). During the follow‐up period (median, 21.0 months), 16 patients developed hypervascular HCC. Patients in the nonclean‐liver group showed a higher incidence of hypervascular HCC than those in the clean‐liver group (3‐year HCC incidence rates: 50.4% and 5.7%, respectively; P < 0.05). A nonclean liver was independently associated with hypervascular HCC development (hazard ratio, 18.75; 95% confidence interval, 4.83–128.63; P < 0.0001), but stiff liver was not (1.91; 0.66–6.23; P = 0.23).Data ConclusionAn HBP hypointense nodule without APHE observed on a gadoxetic acid‐enhanced MR image is a strong indicator of subsequent development of hypervascular HCC in patients with chronic liver disease.Level of Evidence: 2Technical Efficacy Stage: 5J. Magn. Reson. Imaging 2020;51:389–396.
Improved Survival Following Living Donor Liver Transplantation for Pediatric Acute Liver Failure: Analysis of 20 Years of US National Registry Data
Authors: Firl Daniel J. , Sasaki Kazunari , McVey John , Hupertz Vera , Radhakrishnan Kadakkal , Fujiki Masato , Eghtesad Bijan , Miller Charles M. , Quintini Cristiano , Hashimoto Koji 
Published: May 2019

This study estimated the utility of technical variant grafts (TVGs), such as split/reduced liver transplantation (SRLT) and living donor liver transplantation (LDLT), in pediatric acute liver failure (PALF). PALF is a devastating condition portending a poor prognosis without liver transplantation (LT). Pediatric candidates have fewer suitable deceased donor liver transplantation (DDLT) donor organs, and the efficacy of TVG in this setting remains incompletely investigated. PALF patients from 1995 to 2015 (age <18 years) were identified using the Scientific Registry of Transplant Recipients (n = 2419). Cox proportional hazards model and Kaplan‐Meier curves were used to assess outcomes. Although wait‐list mortality decreased (19.1% to 9.7%) and successful transplantations increased (53.7% to 62.2%), patients <1 year of age had persistently higher wait‐list mortality rates (>20%) compared with other age groups (P < 0.001). TVGs accounted for only 25.7% of LT for PALF. In the adjusted model for wait‐list mortality, among other factors, increased age (subhazard ratio [SHR], 0.97 per year; P = 0.020) and access to TVG were associated with decreased risk (SHR, 0.37; P < 0.0001). LDLT recipients had shorter median waiting times compared with DDLT (LDLT versus DDLT versus SRLT, 3 versus 4 versus 5 days, respectively; P = 0.017). In the adjusted model for post‐LT survival, LDLT was superior to DDLT using whole grafts (SHR, 0.41; P = 0.004). However, patient survival after SRLT was not statistically different from DDLT (SHR, 0.75; P = 0.165). In conclusion, despite clear advantages to reduce wait‐list mortality, TVGs have been underutilized in PALF. Early access to TVG, especially from LDLT, should be sought to further improve outcomes.
An augmented reality platform for interactive aerodynamic design and analysis
Authors: Badías Alberto , Curtit Sarah , González David , Alfaro Icíar , Chinesta Francisco , Cueto Elías 
Published: May 2019

SummaryWhile modern CFD tools are able to provide the user with reliable and accurate simulations, there is a strong need for interactive design and analysis tools. State‐of‐the‐art CFD software employs massive resources in terms of CPU time, user interaction, and also GPU time for rendering and analysis. In this work, we develop an innovative tool able to provide a seamless bridge between artistic design and engineering analysis. This platform has three main ingredients: computer vision to avoid long user interaction at the pre‐processing stage, machine learning to avoid costly CFD simulations, and augmented reality for an agile and interactive post‐processing of the results.
The FTO Gene and Measured Food Intake in 5‐ to 10‐Year‐Old Children Without Obesity
Authors: Ranzenhofer Lisa M. , Mayer Laurel E.S. , Davis Haley A. , Mielke‐Maday Hanna K. , McInerney Hailey , Korn Rachel , Gupta Nikita , Brown Amanda J. , Schebendach Janet , Tanofsky‐Kraff Marian , Thaker Vidhu , Chung Wendy K. , Leibel Rudolph L. , Walsh B. Timothy , Rosenbaum Michael 
Published: May 2019

ObjectiveGenetic variation in the first intron of FTO (e.g., single‐nucleotide polymorphism [SNP] rs9939609) is strongly associated with adiposity. This effect is thought to be mediated (at least in part) via increasing caloric intake, although the precise molecular genetic mechanisms are not fully understood. Prior pediatric studies of FTO have included youth with overweight and obesity; however, they have not informed whether a genotypic effect on ingestive behavior is present prior to obesity onset. Therefore, this study investigated the association between FTO and caloric intake in children aged 5 to 10 years without obesity (adiposity ≤ 95th percentile).MethodsA total of 122 children were genotyped for rs9939609 and ate ad libitum from a laboratory lunch buffet following a standardized breakfast. Linear regressions, adjusting for body mass, were used to examine the association between FTO “dose” (number of copies of SNP rs9939609) and intake variables.ResultsThere was a significant association between FTO and total intake. Each risk allele predicted an additional 64 calories, accounting for 3% of the variance. There were no associations between FTO and macronutrient preference, energy density, or diet variety. Results were influenced by race.ConclusionsResults corroborate and extend prior work by showing a dose‐dependent effect on food intake in children without obesity.
Optimal control of fractional neutral stochastic differential equations with deviated argument governed by Poisson jumps and infinite delay
Authors: Durga N. , Muthukumar P. 
Published: May 2019

SummaryIn this work, the optimal control for a class of fractional neutral stochastic differential equations with deviated arguments driven by infinite delay and Poisson jumps is studied in Hilbert space involving the Caputo fractional derivative. The sufficient conditions for the existence of mild solution results are formulated and proved by the virtue of fractional calculus, characteristic solution operator, fixed‐point theorem, and stochastic analysis techniques. Furthermore, the existence of optimal control of the proposed problem is presented by using Balder's theorem. Finally, the obtained theoretical results are applied to the fractional stochastic partial differential equations and a stochastic river pollution model.
A Comparison of Phenolic Monomers Produced from Different Types of Lignin by Phosphotungstic Acid Catalysts
Authors: Du Boyu , Liu Bingyang , Wang Xing , Zhou Jinghui 
Published: May 2019

AbstractHerein we studied the chemical structure of different types of lignin samples and the potential to prepare phenolic monomers was illustrated by phosphotungstic acid catalysts. Different types of H/G/S lignin components had different structures. The lignin extracted from poplar had the highest molecular weight and β‐O‐4 aryl ether contents, followed by pine and straw lignin samples. After depolymerization by PTA catalyst, the yields of phenolic monomers detected was 8.06 wt % (poplar), 5.44 wt % (pine) and 4.52 wt % (straw), respectively. Further, the ratios of H/G/S in the phenol monomers were also different, indicating that the S, G and H types structural units were continuously transformed with each other during the reaction. In our study, the change in the types of lignin samples resulted into an improvement of the distribution of phenolic products, and also the selectivity of phenolic monomers significantly.
Current Trends in Steroid Dose Choice and Frequency of Administration of Epidural Steroid Injections: A Survey Study
Authors: Vydra Darrell , McCormick Zack , Clements Nate , Nagpal Ameet , Julia Jonathan , Cushman Daniel 
Published: May 2019

BackgroundEpidural steroid injections (ESI) are commonly used to treat refractory radicular spinal pain. Although evidence suggests that an increasing cumulative dose of exogenous corticosteroid may be harmful, knowledge of current practice patterns is limited regarding the choice of dose and frequency of epidural steroid injections (ESIs).ObjectiveDescribe current practice trends in the dose selection and frequency of administration of transforaminal ESIs (TFESIs) and interlaminar ESIs (ILESIs).DesignCross‐sectional survey study.SettingNot applicable.ParticipantsThree hundred fourteen physician members of the Spine Intervention Society (SIS). From May to June 2018, an online survey was distributed to 5907 physician members of the SIS.InterventionsNot applicable.Main Outcome MeasuresCorticosteroid dose used by practitioners and the number of annual ESIs administered per patient.ResultsThree hundred fourteen physicians responded to the survey. For single cervical or lumbar injections of dexamethasone, most physicians (56.0%) reported using 10 mg; 17% of physicians reported use of doses greater than 10 mg, with 6% using a dose of 20 mg per injection level. The most common particulate corticosteroid dose used during both cervical and lumbar ILESIs was 80 mg (cervical = 55.4%, lumbar = 54.7%). During cervical and lumbar ILESIs, 17% and 12.7% of physicians reported using doses greater than 80 mg, respectively. Almost 10% of physicians reported performing cervical TFESIs with particulate steroids. Forty percent of physicians reported allowing four ESIs at a given spinal segmental level per year (cervical/thoracic/lumbosacral). A small percentage of physicians reported allowing more than six ESIs annually (6%) and >10 injections annually (1%).ConclusionsThere is considerable variability among this large cohort of interventionists with regard to corticosteroid dose selection and epidural steroid injection frequency. A small proportion of respondents reported Mulitsociety Pain Workgroup guideline‐discordant use of particulate steroids during cervical TFESIs. These findings demonstrate a need for additional research regarding both the reasons for such variation in care and the reasons for guideline‐discordant practice in a subset of physicians.Level of EvidenceIV.
In‐Depth Proteomic Analysis of Human Bronchoalveolar Lavage Fluid toward the Biomarker Discovery for Lung Cancers
Authors: Sim Seo Young , Choi Yu Ri , Lee Jun Hyung , Lim Jae Min , Lee Seung‐Eun , Kim Kwang Pyo , Kim Jin Young , Lee Seung Hyeun , Kim Min‐Sik 
Published: May 2019

PurposeLung cancer is among the most common cancers. Bronchoalveolar lavage fluid (BALF) can be easily obtained from patients with lung cancers. The aim is to develop a novel proteomic method of the molecule‐based sensitive detection of biomarkers from BALF.
Experimental DesignBALF samples are collected from segmental bronchus of 14 patients with lung cancers from Kyung Hee University Hospital. First, BALF proteome is depleted using a depletion column, and then peptides are prepared from the enriched low abundant proteins and fractionated by high pH reverse phase liquid chromatography prior to LC‐MS/MS. Data are available via ProteomeXchange with identifier PXD012645.ResultsA novel method is developed for in‐depth proteomic analysis of BALF by combining antibody‐based depletion of high abundant proteins from BALF with high pH peptide fractionation. Peptides are analyzed on a high resolution Orbitrap Fusion mass spectrometer. MaxQuant search result in the identification of 4615 protein groups mapped to 4534 genes.
Conclusions and Clinical RelevanceIt is found that the method outperformed conventional BALF proteomic methods and it is believed that this method will facilitate the biomarker research for lung cancer. In addition, it is shown that BALF will be a great source of biomarkers of lung diseases.
Development and Validation of a Multiresidue Method for Fluazifop‐p–butyl and Its Two Major Relevant Metabolites in Panax ginseng Using a Modified QuEChERS Method and HPLC‐ESI‐MS/MS
Authors: Li Guangling , Hou Zhiguang , Lu Zhongbin , Chen Xiling 
Published: May 2019

AbstractFluazifop‐p‐butyl (FPB) is used to control the gramineous weeds in Panax ginseng field, which has the risk of exceeding the maximum residue limit of FPB in Panax ginseng. A modified QuEChERS sample preparation method was developed for the simultaneous determination of FPB and its two major relevant metabolites, fluazifop‐p‐acid (FP) and 2‐hydroxy‐5‐ trifluoromethylpyridin (TFMP) in Panax ginseng by using Carboxylated multi‐walled carbon nanotubes (MWCNTs‐COOH) mixed with ostade‐cylsilane (C18), primary secondary amine (PSA), and graphitized carbon black (GCB) as purification materials. Furthermore, the HPLC‐MS/MS parameters were optimized. The method was further validated by determining the linearity (R2>0.999), fortified recovery (77.6‐97.8%), relative standard deviation (<13.6%) and sensitivity (LOQ, 2.0‐ 8.6 μg kg‐1 for FPB, 3.9‐5.8 μg kg−1 for FP and 3.5‐9.0 μg kg−1 for TFMP in Panax ginseng root, leaf, and seed samples, respectively). The main advantages of the method are high recovery, high sample throughput, facile sample preparation, a smaller volume of organic solvents and low cost per sample. The entire method can withstand practice testing expected to be used for the screening of FPB residue in Panax ginseng samples.
Fabrication of Al2O3/IL‐Based Nanocomposite Polymer Electrolytes for Supercapacitor Application
Authors: Gunday Seyda Tugba , Cevik Emre , Yusuf Abdulmalik , Bozkurt Ayhan 
Published: May 2019

AbstractIn the present work, we investigated physical properties as well as supercapacitor application of nanocomposite polymer gel electrolytes. The polymer electrolyte (PE) consists of Ionic Liquid, (1‐Ethyl‐3‐methyl‐imidazolium tetrafluoroborate (IL)) as a softening agent, aluminum oxide (Al2O3) as a nano additive and sulfonated polysulfone (SPSU) as the main polymer. The resulting nanocomposite gel polymer electrolyte structure was characterized using spectroscopic methods. Thermal characteristic properties of polymeric nanocomposites were investigated by performing differential scanning calorimetry (DSC) and terhmogravimetric analysis (TGA). Conductivity measurements of the materials were obtained between −20 °C and 100 °C at varying temperature intervals. The highest ionic conductivity values were obtained from the SPSU / 0.1 IL and SPSU / 5% Al2O3 / 0.2 IL polymer electrolyte structures as 2.5 x10−4 and 2.06 x10−3 S cm−1 at 100 °C, respectively. The maximum specific capacitance value of 144 F g−1 was obtained from SPSU / 5% Al2O3 / 0.2 IL polymer electrolyte based system at a current density of 1 A g−1. The supercapacitor reached an energy density of 20 Wh kg−1 at a power density of 1028 W kg−1. In addition, the supercapacitor has shown a remarkable capacitance retention with a performance loss of only about 10% after 5000 cycles.
Cytotoxicity and Crystal Structures of Nitrosoruthenium Complexes mer‐[Ru(NO)Py2Cl3] and mer‐[Ru(NO)(γ‐Pic)2Cl3]
Authors: Makhinya Alexander N. , Eremina Julia A. , Sukhikh Taisiya S. , Baidina Iraida A. , Il'in Maxim A. , Klyushova Lyubov S. , Lider Elizaveta V. 
Published: May 2019

AbstractThe reaction of K2[Ru(NO)Cl5] with excess of pyridine or γ‐picoline in DMF solution at high temperature gives mer‐[Ru(NO)Py2Cl3] (I) and mer‐[Ru(NO)(γ‐Pic)2Cl3] (II), correspondingly, that were obtained with high yields (∼80%) by filtration of concentrated solutions. There is another method for this synthesis that consists of reaction of the same salt with respective heterocycle in water solution with following evaporation with ethanol addition (yield is ∼95%). The crystal structures of the compounds were determined by X‐ray single‐crystal diffraction analysis. Synthesized compounds were characterized by elemental analysis, TGA, IR‐ and NMR‐spectroscopy. The title complexes and related compounds fac‐[Ru(NO)Py2Cl3] (III), cis‐[Ru(NO)Py2Cl2(OH)] (IV), trans‐[Ru(NO)Py2Cl2(OH)] (V), trans‐[Ru(NO)Py4(OH)]Cl2⋅H2O (VI), trans‐[Ru(NO)Py4Cl]Cl2⋅H2O (VII) were examined on cytotoxic activity towards Hep‐2 cancer cell line and HEK‐293 cell line. All the complexes have shown a dose‐dependent cytotoxic effect, complex II has the lowest IC50 value.
One‐Pot Multicomponent Synthesis of β‐Lactams via In Situ Generated Imines
Authors: Mozaffari Abolfazl , Jarrahpour Aliasghar , Alborz Maryam , Turos Edward 
Published: May 2019

AbstractAn efficient, atom‐economic, multi‐component reaction protocol has been developed for the synthesis of β‐lactams. This new procedure employs a one‐pot sequential multicomponent Staudinger reaction between acetic acid derivatives and imines generated in situ by thermal melting of an aryl or heteroaryl aldehyde with the primary amine. The protocol has the merits of simple operation, short reaction time, convenient work‐up, good yields, applicability to a broad range of substrates, cheap and less hazardousness to humans and environment. The structures of the β‐lactam adducts E1‐30 were characterized by spectral (FT‐IR, 1H‐NMR, 13C‐NMR, GC‐MS) and elemental analyses.
Synthesis of Meso/Macroporous γ‐Alumina via Aluminum Pellet with Controllable Porosity: Ammonium Bicarbonate Influences through Drying and Calcination Steps
Authors: Bamdadi Milad , Bozorg Ali , Tavasoli Ahmad , Shateri Saeid , Andache Mahmoud 
Published: May 2019

AbstractMesoporous and macroporous γ‐alumina have been synthesized using the economic source of aluminum pellets. To manipulate the porosity and overall porous characteristics, ammonium bicarbonate was incorporated into the gel and studied to determine its influence on the porous structure of the obtained γ‐alumina. The nanostructure of the synthesized γ‐alumina, characterized by the N2 sorption isotherms and FESEM analysis, indicated that the γ‐alumina of desired pore size distribution could be achieved using such economical source of aluminum when ammonium bicarbonate was considered to tailor its porous structure. The formation of macropores in synthesized γ‐alumina was confirmed by the FESEM images and the crystalline structure of the γ‐alumina of optimal porous structure was revealed via X‐ray diffraction pattern. Before and after being calcinated at 500 °C, TG‐DTA and FT‐IR analyses were also conducted to better assess the impact that thermal processes could have on ultimate γ‐alumina porous characteristics. Considering the embedded ammonium bicarbonate expander, a two‐step mechanism was finally proposed to explain the observed porosity developed through heating stages. Different porosity patterns developed through drying and calcination steps were then contributed to the reactions taking place at each, and N2 sorption isotherms, as well as the FESEM images, were used to evaluate the introduced pore forming mechanisms.