bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pegylated versus non-pegylated interferon beta 1a in patients with relapsing-remitting multiple sclerosis: A cost-effectiveness analysis
Authors: Hashemi-Meshkini Amir , Zekri Hedieh Sadat , Karimi-Yazdi Hasan , Zaboli Pardis , Sahraian Mohammad Ali , Nikfar Shekoufeh 
Published: January 2019

Background: Pegylated (PEG) interferon beta 1a has been approved by the United States Food and Drug Administration (USFDA) as an alternative to interferon beta 1a for multiple sclerosis (MS). Due to its higher price, this study aimed to evaluate the cost-effectiveness of PEG-interferon beta 1-a compared with interferon beta 1a from an Iranian payer perspective.
Methods: A Markov model was designed according to health states based on Expanded Disability Status Scale (EDSS) and one-month cycles over a 10-year time horizon. Direct medical and non-medical costs were included from a payer perspective.
Results: The incremental cost-effectiveness ratio (ICER) was estimated around 11111 US dollars (USD) per quality-adjusted life-year (QALY) gained for the PEG-interferon versus interferon regimen [with currency rate of 29,000 Iranian Rial (IRR) to 1 USD in 2016].
Conclusion: Considering the cost-effectiveness
threshold in Iran [three times of gross domestic product (GDP) per capita or 15,945 USD], PEG-interferon beta 1-a could be considered as a cost effective treatment for Iranian patients with MS.
Induction or aggravation of other immune-mediated disorders by disease-modifying therapy in treatment of multiple sclerosis
Authors: Baghbanian Seyed Mohammad , Sahraian Mohammad Ali 
Published: January 2019

Interferon beta (IFN-β) and glatiramer acetate (GA) are the primary therapeutic immunomodulatory agents that interfere with relapsing-remitting multiple sclerosis (RRMS), and the most commonly-used drugs as well. Induction or aggravation of other immune-mediated diseases has been reported following INF-β administration. We have reviewed the reported cases to notify the treating physicians about these rare adverse events. Although co-morbid autoimmune disorders have been reported in patients with MS, the pro-inflammatory role of disease-modifying drugs, especially INF-β, could affect and enhance this co-occurrence. Clinical or laboratory autoimmunity histories suggest the use of GA over INF-β as the treatment of choice.
Oxidative stress-related biomarkers in Parkinson’s disease: A systematic review and meta-analysis
Authors: Khan Zeba , Athar Ali Sharique 
Published: January 2019

Parkinson’s disease (PD) is a neurodegenerative disease characterized with the loss of dopamine-producing neurons in a mid-brain. This loss is believed to be associated with number of environmental and genetic factors. Oxidative stress is found to be one of the factors responsible for the initiation and progression of PD. However, studies are still continued to confirm the connection and mechanism associated with oxidative stress and PD. This systematic review and meta-analysis aimed to assess the association between oxidative stress markers and PD, and explore factors that may elucidate the contradictions in these results. As per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline systematic literature search was carried out. Meta-analysis was carried out on pooled standardized mean differences with 95% confidence interval (CI) of patients with PD and controls using random effect model in comprehensive meta-analysis statistical software. Total 17 studies were included into which 25 oxidative stress markers were analyzed. The results revealed that oxidative stress markers [nitrate and nitric oxide (NO)] and antioxidant markers [total antioxidant status (TAS) and thiols] were not statistically different between the PD and control group (P > 0.05). In case of oxidative stress markers, levels of malondialdehyde (MDA), 8-Oxo-2'-deoxyguanosine (8-oxo-dG), and lipid hydro-peroxide (LPO) were found to be high in patients with PD as compared to controls with P < 0.05, whereas lower levels of antioxidant activity of superoxide dismutase (SOD), glucose 6 phosphate dehydrogenase (G6PD), catalase (CAT), and glutathione peroxidase (GPx) were noticed in the PD group as compared to controls (P < 0.05 for all). From the results, it is concluded that patients with PD have high oxidative stress and lower antioxidant activity, and these studied biomarkers would be used as potential diagnostic tool to measure oxidative stress in patients with PD.
STYLISTICS ANALYSIS ON LITERATURE LEARNING MATERIAL OF BAHASA INDONESIA CURRICULUM 2016 SMA-MA-SMK
Authors: Ismawati Esti , Widayanti Sukasih Ratna 
Published: January 2019

ABSTRACT
This study aims to analyze literature learning material Class X SMA-MA-SMK in Curriculum Bahasa Indonesia 2016. The method is descriptive by referring to the stylistics study. The problem is how is the linguistic description of literature learning material above?. The findings can be concluded that the poet uses the single and complex sentences. It also uses the rhetorical sentence, parallelism, repetition, metaphor, and climax in poems. The chosen vocabulary by the author is the common vocabulary which they use in our daily life, however it has special meaning when it is arranged in the form of poetry. The imagination in their poems is very strong. It can be seen through visual, auditory, and tactile.
Keywords: stylistics study, linguistics aspect, literature material, curriculum 2016
ENVIROMENTAL INSIGHT IN UCIL THE MOUSE DEER FAIRY TALE COLLECTION WRITTEN BY TRIA AYU K (AN ECOCRITIC STUDY)
Authors: Setyowati Nanik , Emzir Emzir 
Published: January 2019

ABSTRACT
The connection of nature with literary works raises concepts about ecological problems in literature among literary critics. Many environmental problems that occur at this time. Through poetry, fairy tales and other literary works, the writers mention this in their works. Ecocritic has a basic paradigm that every object can be seen in ecological networks, and ecology can be a helpful science in this critical approach. Environmental insight can be obtained through a literary work. Some writers in Indonesia make nature and the environment a prominent part of their works. In addition to literary works such as poetry and novels, fairy tales have first explored nature. In fairy tales, nature is described as the place of life of the characters. That way, fairy tales indirectly invite the audience to come into contact with environmental insights that need to be studied and applied in everyday life.
Keywords: environmental insight ; ecocritic; fairy tale; literary studies
INJUSTICE REPRESENTATION IN THE POETRY ANTHOLOGY NYANYIAN AKAR RUMPUT BY WIJI THUKUL (An Analysis Study of Critical Literacy)
Authors: Rishanjani Fetti Astrini , Rafli Zainal , Zuriyati Zuriyati 
Published: January 2019

ABSTRACT
The aim of this research is to do an in-depth study of the representation of injustice cointaned in the anthology of poetry Nyanyian Akar Rumput written by Wiji Thukul and its implication in learning Indonesian language. This research is a qualitative research using descriptive analysis method. The research concludes that the analyzed poems represent acts of injustice, such as commutative and recreative injustice. The results of this research showed: (1) Representation of commutative injustice was found in the poem entitled â€œTanahâ€ that revealed the peopleâ€™s demand of justice caused by land expropriation;(2) Representation of recreative injustice was found in the poem entitled â€œBatas Panggungâ€ that revealed the opposition caused by the lack of freedom in voicing their aspirations;(3) The implication of this research can be used by teachers and students as learning materials for literary study.
Keywords: representation of injustice, poetry, critical literacy
SELF-INTEGRITY OF THE MAIN CHARACTER IN THE MOVIE THE RON CLARK STORY BY RANDA HAINES (A STUDY OF PSYCHOANALYSIS THEORY)
Authors: Apriani Tuti 
Published: January 2019

ABSTRACT
This research examined the self-integrity of the main character in the movie The Ron Clark Story by Randa Haines. The focus of this research was to know the self- integrity through the portrayal of personality by using Carl Gustavâ€™s psychoanalysis theory. This research used Jungâ€™s psychoanalysis theory which focused on consciousness, personal consciousness, and collective consciousness. This research used qualitative method by taking steps using data collection, data analysis, and data presentation. The result of this research show that Ron Clark is a main character who has self-integrity because the personal consciousness and collective consciousness dominate more than his consciousness or ego.
Key words: main character, self-integrity, psychoanalysis, and movie.
TWOFER: USING CDA IN THE CLASSROOM FOR ENHANCING STUDENTSâ€™ LANGUAGE SKILLS AND CRITICAL THINKING
Authors: Hidayati Istiqlaliah Nurul 
Published: January 2019

ABSTRACT
Nowadays, through technology, information spreads very rapidly. When something happens in one place, in a second it can be known by other people in other faraway places. Unfortunately the information is not always true. Many irresponsible people create misleading information and spread it massively which is known as hoax. This misleading information can provoke many bad effects even sometimes it is dangerous. The hoax can contain hatred, false health information, untrue disaster warning, and so on. This phenomena cannot be ignored. There have been many victims. To protect people from hoax can be done by training their critical thinking ability. One of the ways to make people able to think critically is through the implementation of critical discourse analysis (CDA). This research is aimed at building studentsâ€™ critical thinking and also improving their English skills through the use of CDA. The method employed in this study was action research which was also completed by a focused group discussion. The research result shows that the students could improve their English skills and became more critical in writing a response to a text given by the lecturer by analyzing the text using the principles of CDA, not merely relying on their own opinion.
Keywords: Critical Discourse Analysis; Critical Thinking Ability; English Language Skills
PHRASEOLOGY DISCOURSE IN AIR TRAFFIC CONTROLLERâ€™S COMMUNICATION
Authors: Batubara Khairunnisa 
Published: January 2019

ABSTRACT
This writing deals with the types of phraseology in air traffic controllerâ€™s communication. The objective of this writing is to find out the types of phraseology used in communication between ATC of KNIA and pilot. The source of this writing is an air traffic controller of KNIA. The data of this writing are the communication between controller and pilot which spoken in statements or commands called phraseology (words and phrases). Descriptive qualitative method is applied as a qualitative design in conducting this research. The instrument of data collection is voice recorder to record the data.
Keywords: phraseology, air traffic controller, communication
Google Translate as an Alternative Tool for Assisting Students in Doing Translation : A Case Study at Universitas Negeri Jakarta, Indonesia
Authors: Herlina Ninin , Dewanti Ratna , Lustiyantie Ninuk 
Published: January 2019

Abstract
The paper examines the use of Google Translate as an Alternative tool for assisting students at Universitas Negeri Jakarta, Indonesia to translate and develop their knowledge and skills in doing Translation. The participants of the study were 36 students at the Applied Linguistic of Doctoral Program at Universitas Negeri Jakarta who had registered of the year 2017. Based on literature review, analysis of the collecting data, and an assessment of the course content and activities inside and outside the learning process, the findings suggest that most Applied Linguistic of Doctoral Program students at Universitas Negeri Jakarta recognize Google Translate as an Alternative tool for doing references book translation. In fact, some students reported that they could optimally ,benefit from self-learning if they were assisted to use Google Translate effectively. Moreover, using Google Translate for doing classroom tasks and reference books translation encourage students to study independently, and to shape their own strategies for solving language problem.
Keywords : Google Translate, Alternative Tool, Translation, Assisting Student
POLITENESS PRINCIPLE: PRESIDENT JOKO WIDODOâ€™S SPEECH ACT IN VIDEO BLOG
Authors: Mufliharsi Risa , Pratiwi Heppy Atma 
Published: January 2019

ABSTRACT
The aim of the research is analyzing the utterances of Mr. Joko Widodo as president of Indonesia with vloggers. In this study, the writer analyzes the rules of president conducting his utterances at vloggersâ€™ vlogs. The vlogs taken from skinnyindonesian24 which has 1.3M subscribers and Arif Muhammad which has 1.5M subscribers (data per November 25, 2018). The data taken and analyzed both qualitative and quantitative data. The elaboration of the methods used to measure language politeness, to count the data whether politenes or not. The data taken from Arif Muhammadâ€™s vlog (1.596.033 subscribers) which entitle Ngevlog bareng Presiden and SkinnyIndonesian24 were created by brothers Andovi da Lopez and Jovial da Lopezâ€™s vlogwho have 1.344.548 subscribers entitleHow to Become a President. The result of this research imply both of the vlogs Mr. Joko Widodo applies politeness strategies even in informal situation both vlogs. He acts extraordinary pragmatic forces and high politeness. So that, the audience gets the emotion, sympathy and persuasion of those who watches of them at vlog.
Keywords: politeness principal, speech acts, vlog, pragmatics
IMPROVING ENGLISH SPEAKING SKILLS THROUGH SCIENTIFIC METHOD ASSISTED GRAPHIC MEDIA (Action Research at SMPN 1 Cikidang Sukabumi)
Authors: Mulyani Eni , Iskandar Ifan 
Published: January 2019

Abstract

The objectives of this study were to find out the effect of implementation of scientific method assisted by graphic media to improve students' English speaking skills. The research used action research design. The subjects were 30 second year eight class students of SMPN 1 Cikidang Sukabumi. Observation, interviews, stionnaires, and documentation were employed to collect the data of the studentsâ€Ÿ learning ctivities and speaking tests were conducted to identify studentsâ€Ÿ speaking achievement. In the scientific method students carry out observing, asking, trying, reasoning and communicating activities, where these activities can train students to speak English. The implementation of this study by applying the scientific method assisted by graphic media is as much as two cycles. In the pre-action stage there were 2 students with a percentage of learning completeness of 6.7%, after the action applied in the first cycle, as many as 8 students with a percentage of learning completeness 26.7% and English speaking skills of students after the second cycle, as many as 28 students with a percentage of 93.3% learning completeness. So, it can be concluded that the scientific method assisted by graphic media can improve English speaking skills of class VIII H students of SMPN 1 Cikidang Sukabumi.

Keyword: scientific method, graphic media, English speaking skill.
MORAL VALUE VIOLATIONS IN AN AMERICAN TRAGEDY NOVEL BY THEODORE DREISER (A Study of Psychoanalisis)
Authors: Agunginardi Muhammad Briyan , Rahmat Aceng , Rozi Fahrur 
Published: January 2019

ABSTRACT

This research is a qualitative research. The technique is content analysis using the data in the form of words, phrases, and sentences. Writer uses a psychoanalysis study. In revealing moral values infringement, writer focuses on three questions; how are the type, cause, and effect of moral values violations in the story. Based on psychoanalysis, there is a moral value infringement. The type of moral values infringement is a murdering case. The cause of moral values violations is a self ambition to reach wealth and prosperity. The effect of moral values violations is a charge of death sentence. Based on the research, there are practical implications in education; to improve the quality and quantity of literature learning in high schools in accordance with the objectives contained in the curriculum. Teachers invites the students to enjoy literature study to differ on good and bad moral teachings and to enhance their ability in using English.

Keywords: Moral, psychoanalisis, novel
Hubungan Hasil Belajar Kewirausahaan dengan Minat Berwirausaha pada Siswa Sekolah Menengah Kejuruan (SMK) Negeri 4 Jakarta Bidang Keahlian Teknik Bangunan
Authors: Handayani Wawan , Daryati Daryati , Murtinugraha R. Eka 
Published: January 2019

Penelitian ini bertujuan untuk mengetahui hubungan antara hasil belajar kewirausahaan dengan minat berwirausaha. Masalah yang diajukan dalam penelitian ini adalah; Apakah terdapat hubungan positif antara hasil belajar kewirausahaan dengan minat berwirausaha. Hipotesis penelitian ini adalah; terdapat korelasi/hubungan positif antara hasil belajar kewirausahaan dengan minat berwirausaha.
Penelitian ini dilakukan di SMKN 4 Jakarta pada semester genap tahun ajaran 2007/08. Populasi penelitian ini adalah siswa kelas XI(Tingkat II) Bidang Keahlian Teknik Bangunan dan sampel diambil pada program keahlian Teknik Konstruksi Kayu (Teknik Perabot Kayu) tingkat II. Metode penelitian yang digunakan yaitu metode korelasional. Pengukuran menggunakan dua instrumen yang berbeda; untuk instrumen hasil belajar kewirausahaan diperoleh dari nilai rapor/ LHS pada siswa semester 4/genap tahun ajaran 2007/08, sedangkan untuk minat berwirausaha menggunakan angket/kuesioner. Nilai rata-rata hasil belajar sebagai variabel bebas (X) adalah 7,57 dan skor rata-rata minat berwirausaha sebagai variabel terikat (Y) adalah 135,59.
Uji persyaratan analisis yang digunakan dalam penelitian ini adalah uji normalitas dan uji linieritas. Uji normalitas digunakan digunakan uji One Sample Kolmogorov-Smirnov untuk hasil belajar kewirausahaan dan minat berwirausaha adalah 0,200 dan 0,200. Data berdistribusi normal karena Angka/ nilai pada signifikasi untuk seluruh variabel lebih besar dari 0,05. Untuk menguji linieritas, peneliti menggunakan Test for Linearity. Dari hasil pengujian data output diperoleh dan diketahui bahwa nilai signifikasi pada liniearity sebesar 0,000. Karena signifikasi kurang dari 0,05 maka dapat disimpulkan bahwa antara variabel hasil belajar kewirausahaan dan minat untuk berwirausaha terdapat hubungan yang linear. Teknik analisis data yang digunakan korelasi product moment yang dilanjutkan dengan uji t. Koefisien korelasi yang diperoleh adalah sebesar 0,992 yang berarti hubungan tersebut sangat kuat.
Evaluasi Pelaksanaan Pembimbingan Dosen Pembimbing Terhadap Mahasiswa PPL FT UNJ
Authors: Daryati Daryati 
Published: January 2019

Tujuan penelitian ini adalah untuk mengevaluasi pelaksanaan bimbingan oleh dosen pembimbing PPL dalam melaksanakan bimbingannya kepada mahasiswa PPL.
Penelitian dilakukan di Fakultas Teknik Universitas Negeri Jakarta dan SMK se-Jakarta, Bogor, Depok, Tangerang, dan Bekasi yang digunakan untuk tempat PPL mahasiswa Fakultas Teknik Universitas Negeri Jakarta. Penelitian ini dilakukan pada semester 096 atau semester genap tahun akademik 2011/2012.
Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif. Data diperoleh dengan pengisian angket oleh dosen pembimbing PPL dan mahasiswa PPL serta guru pamong sebagai verifikasi data.
Sebagai populasi dalam penelitian ini adalah dosen-dosen Fakultas Teknik dari semua program studi kependidikan yang membimbing PPL pada semester genap 2011/2012. Sampel dalam penelitian ini adalah 21 dosen pembimbing dari total 41 dosen pembimbing PPL. Untuk verifikasi data penulis mengambil sampel dari mahasiswa peserta PPL FT UNJ sebanyak 69 mahasiswa PPL dan guru pamong sebanyak 47 guru pamong. Semua sampel diambil secara acak (random sampling). Untuk mengetahui pelaksanaan pembimbingan PPL oleh guru pamong dilakukan analisis dengan persentase.
Hasil penelitian ini menunjukkan bahwa mayoritas dosen pembimbing sudah membimbing secara baik. Pembimbingan dilakukan mulai dari saat pembekalan PPL hingga pasca latihan praktik mengajar. Kehadiran dosen pembimbing masih kurang dari yang seharusnya sehingga perlu ditambah.
History Matching the Full Norne Field Model Using Seismic and Production Data
Authors: Lorentzen Rolf J. , Luo Xiaodong , Bhakta Tuhin , Valestrand Randi 
Published: January 2019

SummaryIn this paper, we use a combination of acoustic impedance and production data for history matching the full Norne Field. The purpose of the paper is to illustrate a robust and flexible work flow for assisted history matching of large data sets. We apply an iterative ensemble-based smoother, and the traditional approach for assisted history matching is extended to include updates of additional parameters representing rock clay content, which has a significant effect on seismic data. Further, for seismic data it is a challenge to properly specify the measurement noise, because the noise level and spatial correlation between measurement noise are unknown. For this purpose, we apply a method based on image denoising for estimating the spatially correlated (colored) noise level in the data. For the best possible evaluation of the workflow performance, all data are synthetically generated in this study. We assimilate production data and seismic data sequentially. First, the production data are assimilated using traditional distance-based localization, and the resulting ensemble of reservoir models is then used when assimilating seismic data. This procedure is suitable for real field applications, because production data are usually available before seismic data. If both production data and seismic data are assimilated simultaneously, the high number of seismic data might dominate the overall history-matching performance.The noise estimation for seismic data involves transforming the observations to a discrete wavelet domain. However, the resulting data do not have a clear spatial position, and the traditional distance-based localization schemes used to avoid spurious correlations and underestimated uncertainty (because of limited ensemble size), are not possible to apply. Instead, we use a localization scheme that is based on correlations between observations and parameters that does not rely on physical position for model variables or data. This method automatically adapts to each observation and iteration.The results show that we reduce data mismatch for both production and seismic data, and that the use of seismic data reduces estimation errors for porosity, permeability, and net-to-gross ratio (NTG). Such improvements can provide useful information for reservoir management and planning for additional drainage strategies.