bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance
Authors: Opdebeeck Britt , Maudsley Stuart , Azmi Abdelkrim , De Maré Annelies , De Leger Wout , Meijers Bjorn , Verhulst Anja , Evenepoel Pieter , D’Haese Patrick C. , Neven Ellen 
Published: April 2019

Significance Statement
Vascular calcification contributes to high cardiovascular mortality in patients with CKD. Although research findings have suggested an association between the uremic toxins indoxyl sulfate and p-cresyl sulfate and cardiovascular disease, direct evidence has been lacking. In this study, the authors demonstrate in a rat model of CKD that continuous exposure to indoxyl sulfate or p-cresyl sulfate promotes moderate to severe calcification in the aorta and peripheral vessels. Activation of inflammation and coagulation pathways in the arterial wall plays a pivotal role in toxin-induced calcification and strongly associates with hyperglycemia and insulin resistance. These findings provide etiologic evidence for indoxyl sulfate and p-cresyl sulfate as major contributors to vascular calcification and suggest new avenues for identifying novel therapeutic targets to prevent or treat calcification in the vessel wall of patients with CKD.

Background
Protein-bound uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (PCS) have been associated with cardiovascular morbidity and mortality in patients with CKD. However, direct evidence for a role of these toxins in CKD-related vascular calcification has not been reported.

Methods
To study early and late vascular alterations by toxin exposure, we exposed CKD rats to vehicle, IS (150 mg/kg per day), or PCS (150 mg/kg per day) for either 4 days (short-term exposure) or 7 weeks (long-term exposure). We also performed unbiased proteomic analyses of arterial samples coupled to functional bioinformatic annotation analyses to investigate molecular signaling events associated with toxin-mediated arterial calcification.

Results
Long-term exposure to either toxin at serum levels similar to those experienced by patients with CKD significantly increased calcification in the aorta and peripheral arteries. Our analyses revealed an association between calcification events, acute-phase response signaling, and coagulation and glucometabolic signaling pathways, whereas escape from toxin-induced calcification was linked with liver X receptors and farnesoid X/liver X receptor signaling pathways. Additional metabolic linkage to these pathways revealed that IS and PCS exposure engendered a prodiabetic state evidenced by elevated resting glucose and reduced GLUT1 expression. Short-term exposure to IS and PCS (before calcification had been established) showed activation of inflammation and coagulation signaling pathways in the aorta, demonstrating that these signaling pathways are causally implicated in toxin-induced arterial calcification.

Conclusions
In CKD, both IS and PCS directly promote vascular calcification via activation of inflammation and coagulation pathways and were strongly associated with impaired glucose homeostasis.
A complexidade da Atenção Psicossocial na Atenção Primária à Saúde: experiências formativas
Authors: Santos Willian 
Published: April 2019

INTRODUÇÃO: Este artigo relata uma experiência de estágio supervisionado desenvolvido no âmbito da graduação em Psicologia em uma universidade pública do interior da Bahia. OBJETIVOS: Esta experiência objetivou que os estagiários vivenciassem a complexidade da Atenção Psicossocial a partir de uma imersão real e efetiva na Atenção Primária à Saúde. MÉTODO: Os estagiários viviam durante um semestre a lógica de uma atuação interprofissional, compondo projetos de intervenção para atuar em Unidades de Saúde da Família, mas também fazendo interface com outros níveis de densidade tecnológica do Sistema Único de Saúde e com outras políticas setoriais, tais como a Assistência Social e a Educação. RESULTADOS E DISCUSSÃO: Este estágio, vivido principalmente através de atividades em grupo, atividades de sala de espera, atendimentos individuais, visitas domiciliares e interconsultas, convocou os discentes a lidarem com situações bastante desafiadoras para a Psicologia: compreender os determinantes sociais envolvidos nos processos de saúde-doença; a necessidade do trabalho multi/interprofissional efetivo, a articulação com a Rede de Atenção à Saúde/Psicossocial, entre outros aspectos. CONSIDERAÇÕES FINAIS: A inserção da Psicologia na Atenção Primária à Saúde deve se pautar na capacidade de ler o contexto das necessidades sociais e de saúde da população para pensar o tipo de cuidado que esta necessita. Faz-se necessário que a Psicologia e seus profissionais ultrapassem as barreiras de uma identidade profissional arraigada no saber biomédico e encontre uma prática e um comprometimento ético-político que cuide do usuário de forma integral e humanizada.
Analisis Faktor-Faktor Yang Mempengaruhi Fiscal Stress
Authors: Septira Finky , Prawira Ida Farida Adi 
Published: April 2019

AbstractThis study aims to find out how the influence of regional own revenue growth, growth in capital expenditure, and economic growth that is proxied by GDRP influences fiscal stress in Sumatera-based districts and cities in 2014-2016. The population of this study is the district/city government in Sumatera Island which consist of 154 district/ cities. The sample selection was determined based on purposive sampling criteria so that 106 districst/cities governments were sampled in this study. This study uses secondary data in the form Realization of Regional Revenue and Expenditure (LRA APBD) as well as data is in the form of data on Domestic Regional Products and Gross (GDRP). Hypotesis testing tools in this study using E-views 9. From the results of the test, researcher found that the growth of regional own revenue and economic growth that is proxied by GDRPaffect fiscal stress while the growth of capital expenditure does not affect fiscal stress. Keywords. Capital Expenditure; Economic Growth; Fiscal Stress; PDRB; Regional Own Revenue. AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh pertumbuhan pendapatan asli daerah (PAD), pertumbuhan belanja modal, dan pertumbuhan ekonomi yang diproksikan dengan PDRB berpengaruh terhadap fiscal stress pada kabupaten dan kota se-Sumatera tahun 2014-2016. Populasi penelitian ini adalah pemerintah daerah kabupaten /kota di Pulau Sumatera yang terdiri dari 154 kabupaten/kota. Pemilihan sampel ditentukan berdasarkan kriteria purposive sampling sehingga didapatkan 106 pemerintah kabupaten/kota yang menjadi sampel dalam penelitian ini. Penelitian ini menggunakan data sekunder berupa Laporan Realisasi Anggaran Pendapatan dan Belanja Daerah (LRA APBD) serta data berupa data Produk Regional Domestik dan Bruto (PDRB). Alat uji hipotesis dalam penelitian ini menggunakan software Eviews 9. Dari hasil pengujian didapatkan bahwa pertumbuhan PAD dan pertumbuhan ekonomi yang diproksikan dengan PDRB berpengaruh terhadap fiscal stress sedangkan pertumbuhan belanja modal tidak berpengaruh terhadap fiscal stress. Kata Kunci. Belanja Modal; Fiscal Stress; Pendapatan Asli Daerah; PDRD; Pertumbuhan Ekonomi.
Las vías verdes como modelo de desarrollo turístico. El caso de la vía verde del noroeste de la Región de Murcia (España)
Authors: Ballesteros Pelegrín Gustavo Alfonso , López Córdoba Victor 
Published: April 2019

La Vía Verde es el nombre que reciben los recorridos peatonales y ciclistas en el medio natural resultado del acondicionamiento de infraestructuras en desuso, principalmente antiguos trazados ferroviarios o carreteras sin servicio. El objetivo de este estudio es analizar las iniciativas de las diferentes administraciones y organizaciones para realizar las necesarias inversiones en acondicionar todos los tramos y dotar de las infraestructuras necesarias, mediante la consulta de documentación bibliográfica. El estudio ha permitido comprobar que la Vía Verde del Noroeste de la Región de Murcia, que recorre 78 Km entre las ciudades de Murcia y Caravaca, ha sido utilizada en 2017 por casi 350 mil usuarios, lo que representa el doble de hace 5 años y se ha convertido en un modelo de desarrollo turístico, que favorece el desarrollo socioeconómico y ambiental de toda una Comarca.
Burden of congenital heart diseases in a tertiary cardiac care institute of high altitude area
Authors: Tramboo Zubair Mushtaq , Patigaroo Aamir Rashid , Ahmad Nazir 
Published: April 2019

Background: Congenital heart disease is one of the major causes of mortality and morbidity in the paediatric population of both the developing and developed countries. Variability in incidence and prevalence of CHD from various countries of Indian subcontinent and rest of the world could be because of genetic, cultural, and environmental factors. The objective of the study was to find the prevalence and pattern of CHD in a tertiary care hospital in Kashmir (Jammu and Kashmir).Methods: All children admitted at territary care hospital with age 0-15 years were screened for congenital heart disease. The study was conducted for period of one year to ascertain the prevalence and spectrum of CHDs.Results: A total of 232 patients out of 23000, were found having CHDs measuring a prevalence of 10.5/1000. About 170 (73%) were the acyanotics, and 62 (27%) were cyanotic heart patients. Among the acyanotic heart diseases ventricular septal defect was the most frequent lesion seen in 54 (23%), followed by patent ductus arteriosus in 50 (22%) children. Among the cyanotic heart diseases tetralogy of Fallot was the most frequent cyanotic heart disease seen in 15 (6.4%) patients.Conclusions: Authors observed high prevalence of CHD in our population. The pattern and spectrum of CHD were comparable to national and international data.
A Realidade das Decisões sobre Liberdade de Expressão, Honra e Imagem no STF e no STJ
Authors: Hartmann Ivar 
Published: April 2019

O problema da previsibilidade com relação ao que é lícito expressar segundo um sistema jurídico vigente está diretamente vinculado ao chilling effect. O custo para a sociedade da existência de menos opinião sendo expressada em razão da incerteza sobre se o autor será punido mais tarde ou não. Ou seja, não se trata apenas da função de produção de precedentes para dar previsibilidade sobre como o STF e o STJ protegem a liberdade de expressão, honra e imagem, mas também de gerar material autoritativo que aumente as chances do uso de precedentes operacionalizáveis nas instâncias inferiores. O estudo busca responder a pergunta: quais as condições de qualidade da atuação do STF e STJ? O problema de pesquisa é subdividido em quatro: i) com que frequência os tribunais decidem sobre o assunto?; ii) qual o timing das decisões?; iii) as decisões são tomadas em situações que permitam a análise atenta e completa dos fatos e questões jurídicas do caso?; e iv) as decisões são tomadas pelo STF e STJ como órgão colegiado pleno ou fracionário, conforme a previsão constitucional? Os resultados indicam que os tribunais superiores lidam com carga de trabalho que inviabiliza qualquer chance de uma análise do direito infraconstitucional ou constitucional aplicado ao caso concreto. As condições nas quais trabalham os ministros impedem a qualidade da prestação. Os tribunais não decidem como colegiado e transformaram-se em um conjunto de decisões monocráticas.
Correlates of Perceived Job Performance Among Employed Adults With Multiple Sclerosis
Authors: Rumrill Phillip D. , Roessler Richard , Li Jian , Bishop Malachy , Inge Katherine J. 
Published: April 2019

BackgroundThe expectation to remain in the labor force is a powerful indicator of long-term employment outcomes for people with multiple sclerosis (MS), and it is determined in part by perceived current job performance.ObjectiveThis study identified correlates of perceived job performance among working adults with MS.MethodParticipants included 611 members of nine National Multiple Sclerosis Society chapters representing 21 states and Washington, DC. Participants were employed, and primarily female (81%), older (average age of 48 years), and White (77%).ResultsHierarchical multiple regression analysis revealed that males, Whites, people without or with low levels of cognitive impairment, and those who reported stronger job/person matches and higher levels of job satisfaction were more likely than other participants to positively evaluate their own job performance. The aggregated predictors explained 20% of the variability in participants’ job performance self-ratings.ImplicationsFindings show the complexity in predicting how satisfied employed people with MS are with their overall job performance, which in turn shapes their expectations and intentions about staying in or disengaging from the workforce. The implications of the findings for rehabilitation counseling interventions and for identifying adults with MS who would benefit from early intervention are discussed.
Deprivasi Utama Kemiskinan Multidimensi Antarprovinsi di Indonesia
Authors: Sumargo Bagus , Simanjuntak Naomi Miduk M. 
Published: April 2019

So far poverty alleviation policies are still oriented to the monetary approach, while poverty is multidimensional, this means that multidimensional poverty is defined as the condition of the lack of all existing poverty indicators. This study finds the main deprivation of poverty indicators in each province in Indonesia, so that poverty alleviation programs can be directed and more in line with the main deprivation needs of poverty in an area. Using the data of the National Socio-Economic Survey (Susenas 2014) and Alkire-Foster’s multidimensional poverty measurement method, and with 12 indicators in three dimensions (health, education, and living standards), found that a priority scale of poverty alleviation assistance required by all provinces in Indonesia based on deprivation primarily a relief program t hat deals with old school problems and immunizations, except in Maluku province is a birth attendant and in Papua is a literacy issue. ------------------------------ Sejauh ini kebijakan pengentasan kemiskinan masih berorientasi pada pendekatan moneter, sementara kemiskinan bersifat multidimensi, ini berarti bahwa kemiskinan multidimensi didefinisikan sebagai kondisi kurangnya semua indikator kemiskinan yang ada. Studi ini menemukan deprivasi utama indikator kemiskinan di setiap provinsi di Indonesia, sehingga program pengentasan kemiskinan dapat diarahkan dan lebih sesuai dengan kebutuhan deprivasi utama kemiskinan di suatu daerah. Berdasarkan data hasil Survei Sosial Ekonomi Nasional (Susenas) 2014 dan metode pengukuran kemiskinan multidimensi Alkire-Foster, serta 12 indikator dalam tiga dimensi (pendidikan, kesehatan, dan standar hidup), maka ditemukan skala prioritas bantuan pengentasan kemiskinan yang dibutuhkan di seluruh provinsi di Indonesia berdasarkan deprivasi utamanya, yakni program bantuan untuk mengatasi permasalahan lama sekolah dan imunisasi, kecuali di Provinsi Maluku adalah persoalan penolong kelahiran dan di Papua adalah persoalan melek huruf.
Kualitas semen segar kambing kacang pada suhu 50c dengan lama simpan yang berbeda menggunakan pengencer dan tanpa pengencer
Authors: Setiawan Feri , Kusumawati Enike Dwi 
Published: April 2019

Abstrak
Penelitian ini bertujuan untuk mengetahui kualitas semen segar Kambing Kacang pejantan pada penyimpanan suhu 5oC dengan lama simpan yang berbeda menggunakan pengencer dan tanpa pengencer. Penelitian ini dilakukan di Laboratorium Fakultas Peternakan Universitas Kanjuruhan Malang pada tanggal 6 sampai 11 Februari 2012. Metode penelitian yang digunakan adalah metode percobaan dengan menggunakan Rancangan Acak Lengkap (RAL) Faktorial. Materi penelitian yang digunakan adalah semen segar Kambing Kacang. Berdasarkan hasil penelitian menunjukkan bahwa kualitas spermatozoa Kambing Kacang pada suhu 5oC dengan lama simpan yang berbeda menggunakan pengencer dan tanpa pengencer menunjukkan adanya perbedaan yang sangat nyata (P<0.01). Pada pengamatan motilitas dan viabilitas spermatozoa kambing Kacang pada suhu 5oC baik yang menggunakan pengencer maupun tanpa pengencer menunjukkan adanya perbedaan yang sangat nyata (P<0.01). Tetapi pada pengamatan abnormalitas tidak menunjukkan adanya pengaruh penggunaan pengencer (P>0.01) serta tidak terdapat pengaruh interaksi antara lama simpan dan penggunaan pengencer terhadap abnormalitas spermatozoa kambing Kacang (P>0.01). Namun terdapat pengaruh yang sangat nyata lama simpan terhadap abnormalitas spermatozoa kambing Kacang pada suhu 5oC baik yang menggunakan pengencer maupun tanpa pengencer (P<0.01). Kesimpulan yang diperoleh dari hasil penelitian ini yaitu bahwa penyimpanan semen segar kambing Kacang pada suhu 50C tanpa menggunakan pengencer mempunyai kualitas yang paling baik yaitu mampu bertahan sampai lama simpan ke 42 jam.

Abstract
This research aimed to determine the quality of a fresh semen Kacang goat at 50C temperature the various preservings time within and withouth extender. This research had been performed in Animal Husbandry Faculty of Kanjuruhan University Malang since 6 until 11 February 2012. The research method used was Completely Randomized Design (CRD) Factorial. Research used was fresh semen Kacang goat. The result of the research indicated that spermatozoa quality of Kacang goat at 50C in different preservings time within and without extender showed the significant differentcy (P<0,01). In motility and viability observation spermatozoa of Kacang goat at 50C either with and without extender showed the significant differntcy (P<0,01). But at the abnormality observation it did not show the influence of the usage extender (P>0,01) and there was no interaction influence between the preserving time and the extender usage forwards the abnormality of Kacang goat spermatozoa (P>0,01). But there was a significant influence of preserving time to wards the abnormality of spermatozoa at 50C temperature either with extender and withoud extender (P<0,01). This research result concludes that the Kacang goat fresh semen preserving without using extender is the best quality that it is able to stay freshly until 42 hours.
Pengaruh perendaman benih pada berbagai jenis larutan urin terhadap daya tumbuh kecambah kaliandra (calliandra calothyrsus)
Authors: Kustyorini Tri Ida Wahyu , Hidayati Permata Ika 
Published: April 2019

Abstrak
Penelitian ini bertujuan untuk mengetahui hasil pengaruh perendaman benih pada berbagai jenis larutan urin terhadap daya tumbuh kecambah kaliandra (Calliandra calothyrsus). Materi yang digunakan dalam penelitian ini adalah benih kaliandra sebanyak 100 gr, urin sapi, kambing dan domba sebanyak @1 liter. Metode yang digunakan dalam penelitian ini adalah eksperimental lapang berdasarkan Rancangan Acak Lengkap (RAL) yang terdiri atas 5 perlakuan dan 3 ulangan. Perlakuan penelitian terdiri dari P0 (perlakuan kontrol/tanpa perendaman), P1 (perendaman pada air) dan perlakuan eksperimental dengan perendaman pada berbagai jenis urin dengan konsentrasi 10%, yakni, P2 (larutan urin sapi), P3(larutan urin kambing) dan P4 (larutan urin domba). Variabel yang diamati dalam penelitian ini yaitu daya tumbuh kecambah kaliandra yang meliputi persentase perkecambahan, tinggi bibit, persentase benih mati, dan persentase kecambah normal. Data yang diperoleh dianalisis dengan menggunakan analisis sidik ragam anova tunggal dengan bantuan aplikasi SPSS for Windows,apabila terdapat pengaruh maka dilanjutkan dengan uji. Perendaman pada urin sapi memberikan nilai terbaik pada persentase kecambah (88,33%), tinggi bibit (5,67±0,57)cm, persentase benih mati terendah (11,67±3,51%), dan persentase kecambah normal (91,67±1,52%). Kesimpulan dari hasil penelitian yaitu perendaman benih pada urin sapi memberikan pengaruh terbaik terhadap daya tumbuh kecambah kaliandara (Calliandra calothyrsus).

Abstract
This study aims to determine the effect of seed immersion on various types of urine solution on the growth of Calliandra calothyrsus. The material used in this study was 100 grams of calliandra seed, cow urine, goat urine and sheep urine. The method used in this study was a field experiment based on a Completely Randomized Design (CRD) consisting of 5 treatments and 3 replications. The treatment consisted of P0 (control / no soaking treatment), P1 (immersion in water) and experimental treatment with soaking in various types of urine with a concentration of 10%, namely, P2 (cow urine solution), P3 (goat urine solution) and P4 (sheep urine solution). The variables observed in this study were the growth of kaliandra sprouts which included germination percentage, seed height, percentage of dead seeds, and the percentage of normal sprouts. The data obtained were analyzed using a single ANOVA variance analysis with the help of the SPSS for Windows application, if there was an influence then proceed with the test. Immersion in cow urine gave the best value in the percentage of sprouts (88.33%), seedling height (5.67 ± 0.57) cm, the lowest percentage of dead seeds (11.67 ± 3.51%), and the percentage of normal sprouts ( 91.67 ± 1.52%). The conclusion of the research results is that the immersion of seeds in cow urine gives the best effect on the power of kaliandara sprouts (Calliandra calothyrsus).