bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of strategies to increase drinking‐water access and consumption among 0‐ to 5‐year‐olds
Authors: Cradock Angie L. , Poole Mary Kathryn , Agnew Kaylan E. , Flax Chasmine , Plank Kaela , Capdarest‐Arest Nicole , Patel Anisha I. 
Published: June 2019

SummaryThe objective of this study is to identify promising strategies for improving drinking‐water access and consumption among children aged 0 to 5 years. MEDLINE/PubMed, Embase, ERIC, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched in this review. Studies included peer‐reviewed, full‐text studies from high‐income countries, published in English between January 1, 2000, and January 12, 2018, that evaluated interventions to increase water access or consumption in children aged 0 to 5 years. Twenty‐five studies met inclusion criteria; 19 used an effective intervention strategy to increase water access or water consumption. Three studies addressed both water access and consumption. Frequently used strategies included policy and practice changes, increasing water access and convenience, and education, training, or social support for caregivers. Studies were of fair methodological quality (average score: 18.8 of 26) for randomized studies and of moderate quality (5.1 of 9) for non‐randomized studies. To date, few high‐quality studies with objectively measured outcomes have clearly demonstrated strategies that may influence water intake and consumption among young children aged 0 to 5 years.
The use of metformin, insulin, sulphonylureas, and thiazolidinediones and the risk of fracture: Systematic review and meta‐analysis of observational studies
Authors: Hidayat Khemayanto , Du Xuan , Wu Meng‐Jiao , Shi Bi‐Min 
Published: June 2019

SummaryCertain glucose‐lowering medications have been implicated in the risk of fracture. While there is convincing evidence from randomized controlled trials (RCTs) that thiazolidinedione use is associated with a higher risk of fracture, the effects of metformin, insulin, and sulphonylureas on the risk of fracture remain equivocal because these medications are not generally investigated in RCTs. A meta‐analysis of observational studies to provide further insights into the association between the use of metformin, insulin, sulphonylureas, or thiazolidinediones and the risk of fracture was performed. PubMed and Web of Science databases were searched to identify relevant observational studies. A random effects model was used to estimate the summary relative risks (RRs) with 95% confidence intervals (CIs). The use of insulin (RR 1.49, 95% CI 1.29, 1.73; n = 23 studies), sulphonylureas (RR 1.30, 95% CI 1.18, 1.43; n = 10), and thiazolidinediones (RR 1.24, 95% CI 1.13, 1.35; n = 14) was associated with an increased risk of fracture, whereas the use of metformin was associated with a reduced risk of fracture (RR 0.86, 95% CI 0.75, 0.99; n = 12). Regarding types of thiazolidinediones, both pioglitazone (RR 1.38, 95% CI 1.23, 1.54; n = 5) and rosiglitazone (RR 1.34, 95% CI 1.14, 1.58; n = 5) were positively associated with the risk of fracture. In summary, there is compelling evidence to discourage the use of thiazolidinediones in individuals with an increased risk of fracture, whereas metformin appears to have a good safety profile for the risk of fracture. The reduced risk of fracture with metformin could possibly be due to the reduced overall risk of fracture among metformin users, as this medication is typically prescribed in the early stages of type 2 diabetes mellitus. The use of insulin or sulphonylureas may increase fracture risk; this risk is most likely attributed to an increased risk of hypoglycaemia‐induced falls. Further confirmation by additional RCTs is required to determine whether the observed association between the use of metformin, insulin, or sulphonylureas and the risk of fracture is due to treatment with these medications or confounding factors.
An apple MYB transcription factor regulates cold tolerance and anthocyanin accumulation and undergoes MIEL1‐mediated degradation
Authors: An Jian‐Ping , Wang Xiao‐Fei , Zhang Xiao‐Wei , Xu Hai‐Feng , Bi Si‐Qi , You Chun‐Xiang , Hao Yu‐Jin 
Published: June 2019

SummaryMYB transcription factors (TFs) have been demonstrated to play diverse roles in plant growth and development through interaction with basic helix‐loop‐helix (bHLH) TFs. MdbHLH33, an apple bHLH TF, has been identified as a positive regulator in cold tolerance and anthocyanin accumulation by activating the expressions of MdCBF2 and MdDFR. In the present study, a MYB TF MdMYB308L was found to also positively regulate cold tolerance and anthocyanin accumulation in apple. We found that MdMYB308L interacted with MdbHLH33 and enhanced its binding to the promoters of MdCBF2 and MdDFR. In addition, an apple RING E3 ubiquitin ligase MYB30‐INTERACTING E3 LIGASE 1 (MdMIEL1) was identified to be an MdMYB308L‐interacting protein and promoted the ubiquitination degradation of MdMYB308L, thus negatively regulated cold tolerance and anthocyanin accumulation in apple. These results suggest that MdMYB308L acts as a positive regulator in cold tolerance and anthocyanin accumulation in apple by interacting with MdbHLH33 and undergoes MdMIEL1‐mediated protein degradation. The dynamic change in MYB‐bHLH protein complex seems to play a key role in the regulation of plant growth and development.
C57BL/6 congenic mouse NRASQ61K melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivo
Authors: Petit Valérie , Raymond Jeremy , Alberti Christophe , Pouteaux Marie , Gallagher Stuart J. , Nguyen Mai Q. , Aplin Andrew E. , Delmas Véronique , Larue Lionel 
Published: June 2019

AbstractRAS is frequently mutated in various tumors and known to be difficult to target. NRASQ61K/R are the second most frequent mutations found in human skin melanoma after BRAFV600E. Aside from surgery, various approaches, including targeted therapies, immunotherapies, and combination therapies, are used to treat patients carrying NRAS mutations, but they are inefficient. Here, we established mouse NRASQ61K melanoma cell lines and genetically derived isografts (GDIs) from Tyr::NRASQ61K mouse melanoma that can be used in vitro and in vivo in an immune‐competent environment (C57BL/6) to test and discover novel therapies. We characterized these cell lines at the cellular, molecular, and oncogenic levels and show that NRASQ61K melanoma is highly sensitive to the combination of Mek and Akt inhibitors. This preclinical model shows much potential for the screening of novel therapeutic strategies for patients harboring NRAS mutations that have limited therapeutic options and resulted in poor prognoses.
Fibrolipomatous hamartomas not only on the soles
Authors: Rotunno Roberta , Diociaiuti Andrea , Giancristoforo Simona , El Hachem May 
Published: June 2019

AbstractFibrolipomatous hamartomas are asymptomatic, subcutaneous lumps usually located on the infant's heels. There is wide heterogeneity in the naming of and management of this condition. Ultrasound examination permits a clear distinction from other disorders. We report herein a case of palmoplantar fibrolipomatous hamartomas.
Fibrous hamartoma of infancy associated with bony remodeling and muscle atrophy
Authors: Kozlowski Anna , Murati Michael , Ogilvie Christian , Hess Donavon , Miller Daniel , Hook Kristen 
Published: June 2019

AbstractFibrous hamartoma of infancy (FHI) is a benign, poorly demarcated, unencapsulated hamartoma contiguous with surrounding fat. This case highlights pronounced bony remodeling and muscle atrophy associated with FHI in a 6‐week‐old girl. Emphasis is placed on pathologic diagnosis and mechanisms, treatment considerations, and the multidisciplinary approach utilized in the management of the disorder.
How do leaf wetting events affect gas exchange and leaf lifespan of plants from seasonally dry tropical vegetation?
Authors: Holanda A. E. R. , Souza B. C. , Carvalho E. C. D. , Oliveira R. S. , Martins F. R. , Muniz C. R. , Costa R. C. , Soares A. A. 
Published: June 2019

Abstract

Foliar uptake of dew is likely an important mechanism of water acquisition for plants from tropical dry environments. However, there is still limited experimental evidence describing the anatomical pathways involved in this process and the effects of this water subsidy on the maintenance of gas exchange and leaf lifespan of species from seasonally dry tropical vegetation such as the Brazilian caatinga.

We performed scanning electron, bright‐field and confocal microscopic analyses and used apoplastic tracers to examine the foliar water uptake (FWU) routes in four woody species with different foliar phenology and widely distributed in the caatinga. Leaves of plants subjected to water stress were exposed to dew simulation to evaluate the effects of the FWU on leaf water potentials, gas exchange and leaf lifespan.

All species absorbed water through their leaf cuticles and/or peltate trichomes but FWU capacity differed among species. Leaf wetting by dew increased leaf lifespan duration up to 36 days compared to plants in the drought treatment. A positive effect on leaf gas exchange and new leaf production was only observed in the anisohydric and evergreen species.

We showed that leaf wetting by dew is relevant for the physiology and leaf lifespan of plants from seasonally dry tropical vegetation, especially for evergreen species.
Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof‐of‐concept cohort study
Authors: Contoli Marco , Baraldo Simonetta , Conti Valentina , Gnesini Giulia , Marku Brunilda , Casolari Paolo , Scrigner Paola , Morelli Paolo , Saetta Marina , Spanevello Antonio , Papi Alberto 
Published: June 2019

ABSTRACTBackground and objectiveSymptoms negatively impact the quality of life and long‐term prognosis of patients with chronic obstructive pulmonary disease (COPD). Little is known about the relationship linking airway inflammation and symptoms in stable COPD. In this study, we evaluated whether respiratory symptoms in COPD are related to sputum inflammatory cellular profile and whether symptom changes are associated with changes in airway inflammation.MethodsA total of 40 patients with stable COPD with moderate‐to‐severe airflow obstruction were enrolled. Patients were visited weekly over 4 weeks. At each visit, patients underwent clinical assessments, lung function tests and sputum induction. Patients recorded daily dyspnoea, sputum and cough scores.ResultsThe changes between two consecutive visits in the percent of sputum neutrophils and eosinophils were related to the changes in the cough (P < 0.001; r = 0.63) and dyspnoea scores (P < 0.001; r = 0.58) of the prior week. Furthermore, using regression analyses, we were able to demonstrate that changes in the cough score were specifically associated to the change in neutrophils, while changes in the dyspnoea score and use of rescue medications were associated with changes in eosinophils numbers.ConclusionOur study showed an association between symptoms and the sputum inflammatory profile. In particular, changes in symptoms (cough and dyspnoea) were correlated with changes in the specific sputum inflammatory cell components of airway inflammation (neutrophils and eosinophils, respectively), providing novel information on the mechanisms of disease manifestation.
Patient assessment and selection for pulmonary rehabilitation
Authors: Rochester Carolyn L. 
Published: June 2019

ABSTRACTPulmonary rehabilitation (PR) is beneficial for people with several forms of chronic respiratory disease. Given the existing limitations on availability of PR services, it is important to identify participants who are most likely to benefit from it. Identification of criteria for patient referral to PR is challenging, as chronic respiratory diseases and their medical and psychosocial co‐morbidities place a complex and multifaceted burden on patients. Although research studies have attempted to identify key parameters predictive of ‘responsiveness to PR’, to date no firm physiological, psychosocial or other criteria exist by which optimal patient candidacy can be determined. Moreover, individual factors do not reliably predict successful multidimensional PR outcomes. In general, individuals who remain symptomatic with dyspnoea, fatigue and exercise intolerance; who have difficulty performing activities of daily living (ADL); and who are having difficulty coping with or managing their disease despite optimized pharmacological therapy are potential candidates for PR. Patient assessment and outcome measurement are core essential features of PR. To be considered as a PR programme, rehabilitation programmes must demonstrate, at a minimum, assessment and outcome measurement in regard to exercise capacity, dyspnoea and health‐related quality of life. Additional parameters, including physical activity, nutritional status, tobacco use status, patient knowledge and self‐efficacy, performance of ADL, fatigue, disease exacerbations, hospitalizations and other urgent healthcare utilization, and behavioural outcomes, including coping styles, patient satisfaction and programme metrics, are other relevant and important aspects of patient assessment and outcome measurement that should be considered and undertaken in PR, where feasible.
Health Risk Assessment of Photoresists Used in an Optoelectronic Semiconductor Factory
Authors: Huang Shao‐Zu , Wu Kuen‐Yuh 
Published: June 2019

AbstractPhotoresist materials are indispensable in photolithography, a process used in semiconductor fabrication. The work process and potential hazards in semiconductor production have raised concerns as to adverse health effects. We therefore performed a health risk assessment of occupational exposure to positive photoresists in a single optoelectronic semiconductor factory in Taiwan. Positive photoresists are widely used in the optoelectronic semiconductor industry for photolithography. Occupational exposure was estimated using the Stoffenmanager® model. Bayesian modeling incorporated available personal air sampling data. We examined the composition and by‐products of the photoresists according to descriptions published in the literature and patents; the main compositions assessed were propylene glycol methyl ether acetate (PGMEA), novolac resin, photoactive compound, phenol, cresol, benzene, toluene, and xylene. Reference concentrations for each compound were reassessed and updated if necessary. Calculated hazard quotients were greater than 1 for benzene, phenol, xylene, and PGMEA, indicating that they have the potential for exposures that exceed reference levels. The information from our health risk assessment suggests that benzene and phenol have a higher level of risk than is currently acknowledged. Undertaking our form of risk assessment in the workplace design phase could identify compounds of major concern, allow for the early implementation of control measures and monitoring strategies, and thereby reduce the level of exposure to health risks that workers face throughout their career.
Fluvial shoal water deltas: pre‐vegetation sedimentation through the fluvial–marine transition, Lower Cambrian, English Channel region
Authors: Went David J. 
Published: June 2019

AbstractLower Palaeozoic fluvial systems tend to be more sand‐prone than those of later eras and the nature of coastal environments less certain. Field studies are presented that characterize the fluvial to marine transition over a distance of 80 km, in the Lower Cambrian of the Cotentin Peninsula, northern France. The sedimentary rocks are divided into six facies associations which represent deposition in proximal fluvial, distal fluvial, delta plain, delta front, pro‐delta and offshore carbonate bank environments. The basin fill is sandstone‐dominated and subdivided into three stratigraphic intervals. A 200 to 300 m thick basal interval contains very coarse‐grained fluvial sandstones deposited during a relative sea level lowstand. An overlying interval, 250 to 1500 m thick, is a facies mosaic. Fluvial strata in the north‐west pass laterally south‐east into deltaic and shallow marine pro‐delta sediments. The delta front deposits show repetitively stacked, upward‐coarsening parasequences, 8 to 10 m thick, which reflect the repeated progradation of lobate, fluvially‐dominated deltas onto a shallow marine shelf. The deltas formed following marine transgression and accumulated during a period of gradually rising relative sea level. An upper unit, 130 m thick, containing offshore stromatolitic and oolitic limestones, caps the study interval and represents deposition during a relative sea level highstand. The fluvial and delta distributary channel sandstones of the middle unit contain <1% mudstone. The cohesionless substrate determined that deltaic distributaries were predominantly braided in character and subject to common bifurcations which resulted in an ordered diminution of channel size and competence in a seaward direction. Terminal distributary channels show evidence of migratory levées and mouth‐bars and consistently delivered fine to medium‐grained sand to the delta front. The study highlights an example of pre‐vegetation deltaic sedimentation that was hydraulically organized and predictable, despite being fed by braided fluvial systems with high levels of peak discharge.
Ethnic/Immigrant Entrepreneurship Through the Yellow Pages in Berlin
Authors: Ülker Barış 
Published: June 2019

AbstractSpace is not an ontologically given entity; following this line of reasoning, the paper explores the concept of ethnic/immigrant entrepreneurship in Berlin relying on the yellow pages directoryGelbe Seiten – İş Rehberi(IR, published in German and Turkish). This particular yellow pages directory has become a spatial reflection of migrant entrepreneurial activities since 1996. It has also been playing a crucial role in the self‐representation of migrants after the fall of the Wall. In this context, the paper explores how individuals construct themselves as ethnic/immigrant entrepreneurs by using the IR, which serves as a networking tool for them. To achieve this goal, it looks at three advertisement strategies of entrepreneurs in the IR between 1996 and 2016.
Identification and characterization of permissive cells to dengue virus infection in human hematopoietic stem and progenitor cells
Authors: Hsu Alan Y. , Ho Tzu‐Chuan , Lai Mei‐Ling , Tan Sia Seng , Chen Tsai‐Yun , Lee Meed , Chien Yu‐Wen , Chen Ya‐Ping , Perng Guey Chuen 
Published: June 2019

BACKGROUNDDengue virus (DENV) is a significant threat to public health in tropical and subtropical regions, where the frequency of human migration is increasing. Transmission of DENV from donors to recipients after hematopoietic stem cell transplantation has been steadily described. However, the underlying mechanisms remain unclear.STUDY DESIGN AND METHODSFreshly isolated bone marrow (BM) was subjected to DENV infection, followed by multicolor fluorescence‐activated cell sorting (FACS) analysis. Virus in supernatants was collected and analyzed by plaque assay.RESULTSDENV‐1 to DENV‐4 could effectively infect freshly obtained BM and produced infectious virus. DENV infection did not change the quantitative population of hematopoietic stem and progenitor cells (HSPCs), megakaryocytic progenitor cells (MkPs) and megakaryocytes. Additionally, DENV antigen, nonstructural protein 1, was enriched in HSPCs and MkPs of DENV infected marrow cells. CD34+, CD133+, or CD61+ cells sorted out from BM were not only the major contributing targets facilitating the DENV infection directly but also facilitated the spread of DENV into other cells when cocultured.CONCLUSIONResults suggest that DENV can efficiently infect HSPCs, which might jeopardize the recipients if DENV‐infected cells were subsequently used. We therefore raise the need for DENV screening for both the donors and recipients of hematopoietic stem cell transplantation, especially for donors exposed to endemic areas, to mitigate DENV infection in immunocompromised recipients.
Changes in target volume during irradiation of canine intranasal tumors can significantly impact radiation dosimetry
Authors: Yoshikawa Hiroto , Nolan Michael W. 
Published: June 2019

AbstractNasal tumor size can change during radiation therapy (RT). The amount of peritumoral fluid (eg, mucohemorrhagic effusions) can also fluctuate. How often this occurs and the magnitude of change are unknown. Likewise, there are no data which describe dosimetric effects of these changing volumes during a course of RT in veterinary medicine. This study addresses that gap in knowledge. Using pet dogs with nasal tumors, three CT image sets were created. Different Hounsfield units were applied to the gross tumor volume (GTV) of each image set: unchanged, –1000 (AIR), –1000 (to the portion of the GTV that actually underwent volume reduction during clinical RT; REAL). Two plans were created: 18‐fraction three‐dimensional conformal RT (3DCRT) and three‐fraction intensity‐modulated stereotactic RT (IM‐SRT). For nearby normal tissues and GTV, near‐maximum doses (D2% and D5%) and volumes receiving clinically significant doses were recorded. To verify “AIR” results, thermoluminescent dosimeters recorded dose in cadavers that were irradiated using both 3DCRT and IM‐SRT plans. “AIR” scenario had ≤1.5 Gray (Gy) increases in D2% and ≤3.2 cc increases of volume. “REAL” scenario had ≤0.97 Gy increases in D5% and ≤0.55 cc increases of volume at clinically relevant doses. Both were statistical significant. Results suggest that near‐complete resolution of GTV warrants plan revision.
Open Data, Models, and Codes for Vanadium Redox Batch Cell Systems: A Systems Approach Using Zero-Dimensional Models
Authors: Lee Seong Beom , Mitra Kishalay , Pratt Harry D. , Anderson Travis M. , Ramadesigan Venkatasailanathan , Chalamala Babu R. , Subramanian Venkat R. 
Published: June 2019

Abstract
In this paper, we study, analyze, and validate some important zero-dimensional physics-based models for vanadium redox batch cell (VRBC) systems and formulate an adequate physics-based model that can predict the battery performance accurately. In the model formulation process, a systems approach to multiple parameters estimation has been conducted using VRBC systems at low C-rates (∼C/30). In this batch cell system, the effect of ions' crossover through the membrane is dominant, and therefore, the capacity loss phenomena can be explicitly observed. Paradoxically, this means that using the batch system might be a better approach for identifying a more suitable model describing the effect of ions transport. Next, we propose an efficient systems approach, which enables to help understand the battery performance quickly by estimating all parameters of the battery system. Finally, open source codes, executable files, and experimental data are provided to enable people's access to robust and accurate models and optimizers. In battery simulations, different models and optimizers describing the same systems produce different values of the estimated parameters. Providing an open access platform can accelerate the process to arrive at robust models and optimizers by continuous modification from the users' side.