bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-Related Quality of Life in Turner Syndrome and the Influence of Growth Hormone Therapy: A 20-Year Follow-Up
Authors: Krantz Emily , Landin-Wilhelmsen Kerstin , Trimpou Penelope , Bryman Inger , Wide Ulla 
Published: April 2019

Abstract

Context
The factors that affect the health-related quality of life (HRQoL) of women with Turner syndrome (TS) are controversial.

Objective
The aim was to describe the HRQoL of women with TS with a focus on how given GH treatment and comorbidity influence HRQoL in adulthood and to compare HRQoL of women with TS with that of women in the general population.

Design
Longitudinal cohort study, up to 20 years.

Setting
The Turner Center at the Section for Endocrinology and Department of Reproductive Medicine at Sahlgrenska University Hospital, Gothenburg, Sweden.

Participants
Women with TS (n = 200), age range 16 to 78 years, were included consecutively and monitored every fifth year between 1995 and 2018. Women from the World Health Organization MONItoring of trends and determinants for CArdiovascular disease project were used as reference populations.

Interventions and Main Outcome Measures
HRQoL was measured using the Psychological General Well-Being index and the Nottingham Health Profile. Associations with somatic variables were assessed using longitudinal linear regression models.

Results
HRQoL was not associated with GH treatment in TS in spite of a mean 5.7 cm taller height. HRQoL was only associated with height per se in one of 13 subscales (P < 0.01). HRQoL was negatively affected by higher age, higher age at diagnosis, and hearing impairment in TS. Women with TS reported a similar HRQoL to the reference population.

Conclusions
No association between previous GH treatment and HRQoL was found during the up to 20 years of follow-up in women with TS. HRQoL of women with TS and the reference population was similar.
Dynamic Decision Making in Sequential Business-to-Business Auctions: A Structural Econometric Approach
Authors: Lu Yixin , Gupta Alok , Ketter Wolfgang , van Heck Eric 
Published: April 2019

We develop a dynamic structural model of competitive bidding in multiunit sequential business-to-business auctions. Our model accounts for two notable characteristics of these auctions: (i) bidders have multiple purchase opportunities for the same product, and (ii) winning bidders in each round can acquire multiple units of the same product. We apply the model to bidding data from the world’s largest flower wholesale market at which trades are facilitated through fast-paced, sequential, Dutch auctions. Using a two-step estimation approach, we are able to recover the structural parameters effectively and efficiently. We then conduct policy counterfactuals to evaluate the performance of alternative design choices. The results suggest that the current auction practice still has ample room for improvement. In light of this, we propose an optimization framework that can facilitate auctioneers’ decisions in making the trade-off between revenue maximization and operational efficiency.This paper was accepted by Lorin Hitt, information systems.
Evolução dos Paleocanais da Região Costeira do Rio Grande do Sul durante o Quaternário Tardio
Authors: Weschenfelder Jair , Correa Iran Carlos Stalliviere 
Published: April 2019

Resumo Registros sísmicos revelaram a presença de canais soterrados que dissecavam a planície costeira do Rio Grande do Sul (RS) no Quaternário Tardio. Dois sistemas distintos de paleocanais foram estabelecidos na Lagoa dos Patos: a) “Pleistoceno tardio”, soterrado por um pacote sedimentar de areias e lamas costeiras; b) “Pleistoceno tardio/Holoceno”, recoberto por um pacote de lamas lagunares. O preenchimento dos canais mais novos é de idade holocênica, como indica a datação radiométrica; a sua incisão está relacionada com a última regressão marinha do Pleistoceno tardio, correspondente ao estágio 2 do isótopo de oxigênio. A incisão e o preenchimento do sistema mais antigo estão relacionados ao evento regressivo-transgressivo anterior, correspondente aos estágios isotópicos de oxigênio 6-5. Os paleocanais podem ser conectados com os paleovales previamente reconhecidos na plataforma e talude continental adjacente. Na planície costeira os paleocanais são correlacionados aos cursos atuais dos rios Jacuí e Camaquã.
Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts
Authors: Mensah Elsie T. , Smyrk Thomas , Zhang Lizhi , Bick Benjamin , Wood-Wentz Christina M. , Buttar Navtej , Chari Suresh T. , Gleeson Ferga C. , Kendrick Michael , Levy Michael , Pearson Randall , Petersen Bret T. , Vege Santhi , Enders Felicity , Limburg Paul , Topazian Mark 
Published: April 2019

OBJECTIVES:
Expression of prostaglandin biosynthetic pathway enzymes in mucinous pancreatic cysts is unknown. Cyclooxygenase-2 (COX-2) inhibition is a potential cancer chemoprevention strategy for these lesions. We evaluated the expression of COX-2, cytosolic phospholipase A2 (cPLA2), and protein kinase B (AKT) in the epithelium of pancreatic cysts and correlated enzyme expression with aspirin (ASA) use and cyst fluid prostaglandin E2 (PGE2) concentration.

METHODS:
Pathology of 80 resected pancreatic cysts was reviewed. Expression of COX-2, cPLA2, and AKT was quantified by tissue immunohistochemistry immunoreactivity scores (IRSs). IRS values were compared between cyst types and (in 30 cases) with matched cyst fluid PGE2 concentrations.

RESULTS:
The mean IRS was higher in the epithelium of mucinous vs nonmucinous cysts for COX-2 (6.1 ± 4.7 vs 3.2 ± 2.8, P = 0.01) and cPLA2 (6.9 ± 3.0 vs 2.9 ± 2.9, P < 0.001). Cyst epithelial COX-2 expression was higher in mucinous cysts with low-grade dysplasia vs those with high-grade dysplasia or invasive carcinoma (IRS 8.0 ± 3.9 vs 1.5 ± 2.9, P < 0.001), whereas the opposite was found for cPLA2 (6.2 ± 3.0 vs 8.6 ± 2.3, P = 0.005). Cyst fluid PGE2 concentrations did not correlate with either the IRS or a history of low- to moderate-dose ASA use.

CONCLUSIONS:
COX-2 and cPLA2 are overexpressed in the epithelium of mucinous pancreatic cysts. COX-2 and/or cPLA2 inhibition might prevent the emergence or progression of mucinous pancreatic cysts, but higher doses of ASA or nonsteroidal anti-inflammatory drugs may be necessary to substantially inhibit cyst epithelial COX-2 activity.
Con y contra la economía política del castigo: algunas reflexiones sobre Bourdieu y el castigo
Authors: Sánchez Ignacio González 
Published: April 2019

El siguiente trabajo tiene como objetivo hacer algunas propuestas con el ánimo de intentar superar algunas de las limitaciones de la economía política del castigo. Para ello, se señalarán algunas de las principales aportaciones de esta corriente, a fin de reconocerles su valor e intentar mantenerlas en futuros trabajos. A continuación se repasarán algunas de las críticas más recurrentes. En la tercera parte se propondrán algunas soluciones a partir del trabajo del sociólogo Pierre Bourdieu, quien en su propia obra se planteó superar algunas limitaciones de los enfoques marxistas.
SISTEM KONTROL PROPORSIONAL-INTEGRAL PADA PROSES PASTEURISASI SUSU
Authors: Dharmawan Andre , Marthen Billy , Adam Fadliansyah , Sari Intan Permata , Maulana Rizky 
Published: April 2019

Pasteurisasi merupakan proses pemanas yang terjadi pada produk dibawah titik didih untuk membunuh bakteri agar tetap terjaga kualitas susu. Pada pasteurisasi ini kita bisa memakai LTLT (Low Temperature Long Time) dengan proses pemanas dilakukan selama 30 menit dan HTST (High Temperature Short Time) proses pemanasnya dilakukan selama 15-16 detik. Dengan pasteurisasi diharapkan bisa menghambat bakteri agar tidak masuk ke susu dan mengontrol perkembangan bakteri agar tidak merusak kualitas susu. Sehingga jika dikonsumsi tidak membahayakan kesehatan manusia dan dampaknya bisa menjadi banyak manfaat bagi kesehatan manusia. Didalam susu ada berbagai macam nutrisi (seperti kalsium, protein vitamin, magnesium, fosfor dan masih banyak lagi) jika dikelola secara baik dan benar. Jadi didalam penelitian ini dikembangkan alat untuk menjaga susu agar tetap stabil dalam proses pasteurisasi susu. Pada penelitian ini akan membuat sistem kontroller yang tertanam di kontroller PI untuk mengontrol aktuator dalam bentuk pemanas listrik yang mendapatkan masukan dari sensor suhu MAX6675 K-Thermocouple. Dari hasil pengujian ini setpoint suhu maksimumnya 60°C diperoleh nilai P mencapai 63°C, nilai PI mencapai suhu 63°C, nilai PD mencapai suhu 69°C, nilai PID mencapai suhu 69°C. Hasil dari kontroler PI untuk menstabilkan suhu lebih cepat dan mampu mempertahankan suhu yang baik.
PERANCANGAN SISTEM KONTROL OVER/UNDER VOLTAGE RELAY BERBASIS MIKROKONTROLER PADA SALURAN TEGANGAN 220VAC
Authors: Arsyad Billy Mahdianto , Sofwan Aghus , Nugroho Agung 
Published: April 2019

Gangguan distribusi listrik mengakibatkan terhambatnya aktivitas manusia sehari-hari. Gangguan yang terjadi dapat berbagai macam antara lain adalah lonjakan atau penurunan tegangan listrik (over/under voltage) dan ketidakstabilan tegangan listrik. Untuk itu dibuatlah perancangan sistem kontrol over/under voltage relay ini menggunakan mikrokontroler STM32F103C8T6 dengan aktuatornya berupa relay. Keluaran tegangan rata-rata pada regulator untuk suplai mikrokontroler adalah 3.31V dan 5V. Untuk membaca nilai tegangan AC dari keluaran variable transformator atau listrik normal menggunakan sensor ZMPT101B yang menggunakan penundaan T/4OSG (Orthogonal Signal Generator). Pengaturan gain yang dilakukan pada sensor sebesar VPP=0,72V dilakukan pada tegangan terukur VAC=210 V, dimana nilai VPP adalah tegangan puncak antara positif dengan negatif gelombang keluaran ZMPT101B. Gelombang tersebut berosilasi pada nilai minimum 1,32 V dan nilai maksimum 2,040 V dengan titik offset VDC sebesar 1,677V. Nilai offset ini tidak bernilai 1,65V dikarenakan menyesuaikan tegangan referensi mikrokontroler. Metode kontrol yang digunakan adalah metode on/off pada relay. Keluaran alat menunjukkan 3 kondisi yaitu under voltage dimana tegangan dibawah 216V, normal voltage tegangan 216V-224V, dan over voltage tegangan diatas 224V. Hasil dari pembacaan sensor dan kondisi akan dikirimkan melalui internet ke database dengan mengunakan adalah ESP-01. Dari hasil pengujian menunjukkan sistem telah berjalan sesuai rancangan
Exercise-Intensity Adherence During Aerobic Training and Cardiovascular Response During Resistance Training in Cancer Survivors
Authors: Quevedo-Jerez Koro , Gil-Rey Erreka , Maldonado-Martín Sara , Herrero-Román Fernando 
Published: April 2019

Abstract
Quevedo-Jerez, K, Gil-Rey, E, Maldonado-Martín, S, and Herrero-Román, F. Exercise-intensity adherence during aerobic training and cardiovascular response during resistance training in cancer survivors. J Strength Cond Res 35(8): 2338–2345, 2021—Combined aerobic-resistance training has shown the best benefits has proved beneficial for cancer survivors (CS). To understand the adherence to the aerobic training program (in terms of the intensity and duration of the sessions) and the cardiovascular response to the resistance training program, heart rate (HR) of 48 CS was monitored in each training session with an HR monitor for a 2-year period. During aerobic training, CS had to maintain the intensity in zone 2 (Z2) (between the ventilatory threshold and respiratory compensation point). The time spent below Z2 (Z1), in Z2, and above Z2 (Z3) was assessed in both aerobic and resistance training. The exercise-intensity distribution (aerobic vs. resistance training) was as follows: Z1 6.6 ± 12.8% vs. 34.3 ± 29.9% (p < 0.001); Z2 66.6 ± 29.3% vs. 54.5 ± 27.6% (p < 0.05); and Z3 26.9 ± 29.9% vs. 11.2 ± 20.6% (p < 0.001). The most deconditioned CS (<4.5 metabolic equivalents [METs]) presented the poorest adherence in Z2 and spent the most time in Z3. A significant positive moderate-high correlation was found for the percentage of time in Z3 between resistance and aerobic exercise (r = 0.75, p < 0.001). In conclusion, the individualization of exercise intensity resulted in good adherence to the prescribed intensity. Less fit CS needed more supervision in their training sessions. Resistance training allowed the CS to train in moderate-vigorous intensities of cardiovascular response. Resistance training should have more scope in exercise prescriptions, particularly in deconditioned CS and in the first steps of exercise programs.
Autoregulation by “Repetitions in Reserve” Leads to Greater Improvements in Strength Over a 12-Week Training Program Than Fixed Loading
Authors: Graham Timothy , Cleather Daniel J. 
Published: April 2019

Abstract
Graham, T and Cleather, DJ. Autoregulation by “repetitions in reserve” leads to greater improvements in strength over a 12-week training program than fixed loading. J Strength Cond Res 35(9): 2451–2456, 2021—Autoregulated (AR) training involves altering resistance session parameters based on the athlete's readiness to train. One potential benefit of AR training may be that training intensity can reflect an athlete's increasing strength level throughout a training program and can be contrasted with fixed loading (FL) where the load is stipulated at the start of the program. In this study, 31 resistance-trained men participated twice weekly in an AR or a FL squat program. For the FL group, the load was prescribed as a percentage of the pre-test 1-repetition maximum, whereas for the AR group, the load was prescribed based on the number of “repetitions in reserve,” such that the intensities were theoretically the same (volume was also matched). Both groups showed a significant increase in front squat (FS) and back squat (BS) performance, but the magnitude of this was significantly greater for the AR program (FS: AR +11.7%, FL +8.3%, p = 0.004,

= 0.255; BS: AR +10.8%, FL +7.1%, p = 0.006,

= 0.233). The AR group was trained at a greater intensity (average weekly intensity; FS: AR 83.2 ± 13.3%, FL 80.4 ± 10.0%, p < 0.001,

= 0.240; BS: AR 83.6 ± 12.7%, FL 80.4 ± 10.0%, p = 0.006,

= 0.159). The results of this study support the contention that AR can be used to accommodate the increasing strength level of the athlete during the course of a program and that such a strategy is effective in eliciting greater strength adaptations across 12 weeks.
Dietary Strategies of Modern Bodybuilders During Different Phases of the Competitive Cycle
Authors: Lenzi Jaqueline L. , Teixeira Emerson L. , de Jesus Guilherme , Schoenfeld Brad J. , de Salles Painelli Vitor 
Published: April 2019

Abstract
Lenzi, JL, Teixeira, EL, de Jesus, G, Schoenfeld, BJ, and de Salles Painelli, V. Dietary strategies of modern bodybuilders during different phases of the competitive cycle. J Strength Cond Res 35(9): 2546–2551, 2021—Bodybuilders have used a wide array of nutritional strategies over the years. However, most information on the topic is anecdotal, with limited research about the nutritional habits of modern bodybuilders, especially those from new categories. Accordingly, we sought to compare the dietary routines of bodybuilders from the Men's Physique category during “bulking” and “cutting” phases, while attempting to identify the rationale underpinning these practices. Sixteen experienced male bodybuilding competitors were interviewed during bulking (10–12 weeks before competition) and cutting (1 week before competition) phases, wherein we quantified energy and nutrient intake and determined their rationale and sources of education. Dietary analysis revealed a low carbohydrate intake during bulking, with a further decrease (at p < 0.05) during cutting. A similar decrease (at p < 0.05) from bulking to cutting was shown in the intake of most macronutrients and micronutrients, although intake of protein and almost all the micronutrients was well above the recommendation throughout the competitive cycle. Most of the consumed supplements can be deemed unnecessary or without scientific support. Most athletes reported self-managing their diet and supplement program, without the assistance of nutrition professionals. As such, some of their professed nutritional habits obtained during interviewers were not consistent with the food diary information. Although some dietary strategies used by bodybuilders in the Men's Physique category are consistent with evidence-based practice, most can be considered extreme and lack scientific support. The source of education may help to explain their decision-making.
OTX2 Signals from the Choroid Plexus to Regulate Adult Neurogenesis
Authors: Planques Anabelle , Oliveira Moreira Vanessa , Dubreuil Chantal , Prochiantz Alain , Di Nardo Ariel A. 
Published: April 2019

AbstractProliferation and migration during adult neurogenesis are regulated by a microenvironment of signaling molecules originating from local vasculature, from CSF produced by the choroid plexus, and from local supporting cells including astrocytes. Here, we focus on the function of OTX2 homeoprotein transcription factor in the mouse adult ventricular-subventricular zone (V-SVZ), which generates olfactory bulb neurons. We find that OTX2 secreted by choroid plexus is transferred to the supporting cells of the V-SVZ and rostral migratory stream. Deletion ofOtx2in choroid plexus affects neuroblast migration and reduces the number of olfactory bulb newborn neurons. Adult neurogenesis was also decreased by expressing secreted single-chain antibodies to sequester OTX2 in the CSF, demonstrating the importance of non-cell-autonomous OTX2. We show that OTX2 activity modifies extracellular matrix components and signaling molecules produced by supporting astrocytes. Thus, we reveal a multilevel and non-cell-autonomous role of a homeoprotein and reinforce the choroid plexus and astrocytes as key niche compartments affecting adult neurogenesis.
Do Doctors Need Communication in their Job Places? (A Case in Indonesia)
Authors: Poedjiastutie Dwi , Puspitasari Ratih 
Published: April 2019

ABSTRACTThe current study revealed the communication needs of medical students at Universitas Muhammadiyah Malang (UMM). Three approaches of Need Analysis (NA) were combined in this study; Target Situation Analysis (TSA), Presentation Situation Analysis (PSA), and Pedagogical Need Analysis (PNA). The questionnaires were circulated to medical students. The findings discovered that communication skill was considered important in EMP course. The medical students realized the importance of doctors’ communication in order to enhance better performance in their professional settings. ESP teachers are supposed to give a model of communication; Students also expected that the materials should be authentic. The materials design should have clear and coherent objectives to help the students achieving the communication goals. Moreover, students want ESP teaching put them as close as possible to the workplace situation. ABSTRAKPenelitian ini bertujuan untuk mengidentifikasi kebutuhan materi pembelajaran Bahasa Inggris komunikasi pada mahasiswa kedokteran di Universitas Muhammadiyah Malang. Pendekatan yang digunakan dalam penelitian ini adalah gabungan antara Target Situation Analysis (TSA), Presentation Situation Analysis (PSA), dan Pedagogical Need Analysis (PNA). Dari data yang diperoleh dalam penelitian ini ditemukan bahwa mahasiwa kedokteran merasa mata kuliah EMP (English for Medical Purposes) itu penting untuk menunjang karir dan profesi mereka. Maka dari itu para pengajar mata kuliah ESP (English for Specific Purposes) diharapkan bisa memberikan model-model materi pengajaran Bahasa Inggris untuk komunikasi yang otentik; yaitu materi yang tepat untuk mengasah ketrampilan mereka dalam komunikasi. Bahkan, para mahasiswa kedokteran menginginkan adanya model-model pengajaran ESP yang bisa membawa mereka ke situasi semirip mungkin dengan dunia kerja mereka di kemudian hari. How to Cite: Poedjiastutie, D., Puspitasari, R. (2018). Do Doctors Need Communication in Their Job Places? (A Case in Indonesia). IJEE (Indonesian Journal of English Education), 5(2), 127-142. doi:10.15408/ijee.v5i2.10134
A Multimodal Discourse Analysis of the Interpersonal Meaning of a Television Advertisement in Indonesia
Authors: Hidayat Didin Nuruddin , A Abrizal , A Alek 
Published: April 2019

ABSTRACTThis article attempts to investigate and explore the interpersonal meaning of YOU C1000 on Indonesian television advertisements. This study was conducted qualitatively using case study to check how different semiotic and modes such as music, sound, speech, color, action, and image work together to build the interpersonal meaning. This study discusses the interpersonal meaning in speech and music, interpersonal meaning in movement and interpersonal meaning in image and color. The study aimed to give some contributions to social semiotics studies, television, or video advertisement. YOU C1000 advertisement is successful to attract audiences’ attention. The election of Miss Universe advertisement star, Bali as the shooting location, English as the language function and wedding ceremony as the activity are the significant factors to introduce the product to the market. In addition, its tagline is a successor factor as well. If people hear Healthy Inside and Fresh Outside, they will remember YOU C1000. ABSTRAKArtikel ini bertujuan untuk menginvestigasi and menyelidiki makna interpersonal dari produk ‘YOU C1000’ pada iklan televisi Indonesia. Penelitian ini dilakukan secara kualitatif dengan menggunakan pendekatan studi kasus untuk mengetahui bagaimana semiotik dan moda yang berbeda seperti musik, suara, ucapan, warna, tindakan, dan gambar, dapat berjalan bersama-sama dalam membentuk makna interpersonal. Penelitian ini mengulas makna interpersonal dalam ucapan dan musik, makna interpersonal dalam gerakan, dan makna interpersonal dalam gambar dan warna. Penelitian ini bertujuan untuk memberikan kontribusi pada studi semiotika sosial, televisi, atau iklan video. Iklan YOU C1000 berhasil menarik perhatian penonton. Pemilihan bintang iklan Miss Universe, Bali sebagai lokasi syuting, bahasa Inggris sebagai fungsi bahasa dan upacara pernikahan sebagai aktivitasnya adalah faktor-faktor yang signifikan untuk memperkenalkan produk tersebut ke pasar. Selain itu, ‘tagline’-nya juga merupakan faktor penting lainnya. Jika orang-orang mendengar ‘Healthy Inside and Fresh Outside’, mereka akan mengingat YOU C1000. How to Cite: Hidayat, D. N.., Abrizal., Alek. (2018). A Multimodal Discourse Analysis of the Interpersonal Meaning of a Television Advertisement in Indonesia. IJEE (Indonesian Journal of English Education), 5(2), 119-126. doi:10.15408/ijee.v5i2.11188