bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined analysis of the MF18‐02/MF18‐03 NEOSENTITURK studies: ypN‐positive disease does not necessitate axillary lymph node dissection in patients with breast cancer with a good response to neoadjuvant chemotherapy as long as radiotherapy is provided
Authors: Muslumanoglu Mahmut , Cabioglu Neslihan , Igci Abdullah , Karanlık Hasan , Kocer Havva Belma , Senol Kazim , Mantoglu Baris , Tukenmez Mustafa , Çakmak Guldeniz Karadeniz , Ozkurt Enver , Gulcelik Mehmet Ali , Emiroglu Selman , Mollavelioglu Baran , Yildirim Nilufer , Bademler Suleyman , Zengel Baha , Trabulus Didem Can , Ugurlu Mustafa Umit , Uras Cihan , Ilgun Serkan , Akgul Gokhan Giray , Akcan Alper , Yormaz Serdar , Ersoy Yeliz Emine , Ozbas Serdar , Dilege Ece , Citgez Bulent , Bolukbasi Yasemin , Altınok Ayse , Dag Ahmet , Basaran Gül , Utkan Nihat Zafer , Ozcinar Beyza , Arici Cumhur , AlJorani Israa , Kara Halil , Yigit Banu , Sen Ebru , Erozgen Fazilet , Soyder Aykut , Celik Burak , Kilic Halime Gul , Zer Leyla , Sakman Gürhan , Yeniay Levent , Atahan Kemal , Varol Ecenur , Veliyeva Vefa , Goktepe Berk , Velidedeoglu Mehmet , Karaman Niyazi , Soran Atilla , Aydiner Adnan , Yılmaz Ravza , Ibis Kamuran , Ozmen Vahit 
Published: October 2024

AbstractBackgroundThe omission of axillary lymph node dissection (ALND) remains controversial for patients with residual axillary disease after neoadjuvant chemotherapy (NAC), regardless of the residual burden. This study evaluated the oncologic safety and factors associated with outcomes in patients with residual axillary disease. These patients were treated solely with sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD), without ALND, after NAC.MethodsA joint analysis of two different multicenter cohorts—the retrospective cohort registry MF18‐02 and the prospective observational cohort registry MF18‐03 (NCT04250129)—was conducted between January 2004 and August 2022. All patients received regional nodal irradiation.ResultsFive hundred and one patients with cT1‐4, N1‐3M0 disease who achieved a complete clinical response to NAC underwent either SLNB alone (n = 353) or TAD alone (n = 148). At a median follow‐up of 42 months, axillary and locoregional recurrence rates were 0.4% (n = 2) and 0.8% (n = 4). No significant difference was found in disease‐free survival (DFS) and disease‐specific survival (DSS) rates between patients undergoing TAD alone versus SLNB alone, those with breast positive versus negative pathologic complete response, SLN methodology, total metastatic LN of one versus ≥2, or metastasis types as isolated tumor cells with micrometastases versus macrometastases. In the multivariate analysis, patients with nonluminal pathology were more likely to have a worse DFS and DSS, respectively, without an increased axillary recurrence.ConclusionsThe omission of ALND can be safely considered for patients who achieve a complete clinical response after NAC, even if residual disease is detected by pathologic examination. Provided that adjuvant radiotherapy is administered, neither the SLNB method nor the number of excised LNs significantly affects oncologic outcomes.
Optimizing Synthesis of Anionic Surfactant‐Modified Carbon Black for Enhanced Ammonium Adsorption
Authors: Mohamed Nurul Balqis , Ngadi Norzita , Rushdan Ahmad Ilyas , Yahya Noor Yahida , Mohamed Noor Mohamed Hizam , Inuwa Ibrahim Mohammed , Opotu Lawal Anako , Abu Bakar Aznizam , Nazir Shah Ismail Ya Mohammad , Ali Noorhalieza 
Published: October 2024

AbstractThe increasing levels of ammonium in wastewater pose serious environmental issues, highlighting the urgent need for effective adsorbents to facilitate its removal. Although conventional biological treatment methods have certain drawbacks, adsorption using carbonaceous materials, such as carbon black produced from waste tires, presents a promising alternative for ammonium removal. However, the use of these materials has not been thoroughly investigated. This study focuses on optimizing the synthesis of carbon black modified with anionic surfactants to improve its capacity for ammonium adsorption. Utilizing Response Surface Methodology (RSM) and a Box‐Behnken design, the optimization process examined key variables, including reaction time, surfactant concentration, carbon black dosage, and surfactant type. Comprehensive characterization of the adsorbent was conducted to analyze its surface properties, functional groups, morphology, and elemental composition. The regression models produced highly accurate results with an R2 value of 0.9437. The optimal synthesis conditions were identified as a 12.30‐hour reaction time, a surfactant concentration of 8 mmol/L of sodium dodecylbenzene sulfonate, and a carbon black dosage of 30 g, achieving an ammonium removal efficiency of 84.80 %. This study offers a scalable solution for ammonium removal in wastewater, promising practical applications and future sustainable waste management research.
Transmission Electron Microscopy of Coral Tissue
Authors: Papke Erin , Kennedy Grace E. , Elliott Elizabeth , Taylor Alison , Tolar Bradley B. , Ushijima Blake 
Published: October 2024

AbstractCoral reefs are invaluable ecosystems that are under threat from various anthropogenic stressors. There has been a recent increase in the diagnostic tools utilized to understand how these threats impact coral reef health. Unfortunately, the application of diagnostic tools like transmission electron microscopy (TEM) is not as standardized or developed in coral research as in other research fields. Utilizing TEM in conjunction with other diagnostic methods can aid in understanding the impact of these stressors on the cellular level because TEM offers valuable insight into the structures and microsymbionts associated with coral tissue that cannot be obtained with a conventional light microscope. Additionally, a significant amount of coral tissue ultrastructure has not yet been extensively described, causing a considerable gap in our understanding of cellular structures that could relate to the immune response, cellular function, or symbioses. Moreover, additional standardization is needed for TEM in coral research to increase comparability and reproducibility of findings across studies. Here, we present standardized TEM sample fixation, embedding, and sectioning techniques for coral studies that ensure consistent ultrastructural preservation and minimize artifacts, enhancing the reliability and accuracy of TEM observations. We also demonstrate that these TEM protocols allow for the observation and quantification of bacterial and viral‐like particles within the coral tissue as well as the endosymbiotic microalgae, potentially providing insight into their interactions within coral cells and how they relate to overall coral health and resilience. © 2024 The Author(s). Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Primary fixationBasic Protocol 2: DecalcificationBasic Protocol 3: Sample dissection, secondary fixation, dehydration, and embeddingBasic Protocol 4: Sectioning and grid stainingBasic Protocol 5: Imaging
Design of a Series of Inverse Continuous Modes Power Amplifier Based on Bandpass Filter
Authors: Wang Kun , Cheng Zhiqun , Jia Minshi , Zhu Zheming , Zhong Baoquan , Yang Zhenghao , Li Bingxin 
Published: October 2024

ABSTRACTIn this paper, a broadband high‐efficiency power amplifier (PA) with filtering characteristics is proposed. This PA is designed using a series of inverse continuous modes (SICMs) and adds a novel coupled microstrip line filter structure. The terminal of this structure is composed of microstrip lines cascaded to improve the out‐of‐band suppression effect. This filter can achieve low in‐band insertion loss, high passband selectivity, as well as deep stopband rejection performance simultaneously. A PA was designed and implemented using a 10 W GaN HEMT device, verifying its wideband characteristics. The measurement result shows that the 39.6–41.6 dBm output power (Pout), 61.6%–73.7% drain efficiency (DE), and 8.6–10.8 dB gain are achieved at 2.2–2.9 GHz.
A case of primary duodenal Brunner's gland hamartoma that gradually underwent morphological changes over a period of 10 years
Authors: Sunada Yusuke , Yamane Hiromichi , Ochi Nobuaki , Kirishi Hirohito , Saitou Takako , Miura Masafumi , Nakanishi Hidekazu , Fujiwara Hideyo , Takigawa Nagio 
Published: October 2024

AbstractBrunner's gland hamartoma (BGH) is a benign tumor occurring in the duodenal bulb. BGH is typically asymptomatic, but it has been shown to occasionally cause anemia.The patient was a 76‐year‐old male. In October 2011, he was diagnosed with prostate cancer with multiple bone metastases and was referred to us for the treatment and examination of anemia. Hormonal therapy with androgen receptor antagonists and bisphosphonate administration following orchiectomy improved his symptoms. In August 2012, esophagogastroduodenoscopy (EGD) was performed due to stomach discomfort, revealing a 5 mm semi‐pedunculated polyp in the duodenal bulb, Yamada‐Fukutomi classification type II. Over the next 5 years, the prostate cancer treatment proceeded smoothly, and no endoscopic follow‐up was conducted. In January 2017, during a health checkup, EGD revealed that the polyp in the duodenum bulb had changed morphologically with a distinct stalk measuring 10 mm. As there were no symptoms and only minimal tumor growth, a watchful waiting approach was adopted. In April 2022, due to the rapid progression of anemia, EGD was performed again, showing that the pedunculated polyp had enlarged to 20 mm in maximum diameter with an eroded surface and a stalk extending to 40 mm. Given the tumor enlargement and further examination of anemia, an endoscopic polypectomy was performed in May 2022. Histopathological examination confirmed the diagnosis of BGH. We observed a case of primary duodenal BGH during treatment for advanced prostate cancer, with endoscopic monitoring over 10 years. The morphological changes of BGH were clearly documented via EGD.
Direct observation of an exposed blood vessel in a colonic diverticulum using ultrathin endoscopy
Authors: Suzuki Kensuke , Kikuchi Daisuke , Yamashita Satoshi 
Published: October 2024

AbstractIn recent years, cases of diverticular bleeding have become more common. Although identifying the bleeding diverticulum is difficult, it is even more difficult to identify the exposed blood vessels in the bleeding diverticulum. We experienced a case in which we succeeded in directly observing the exposed blood vessels of a sigmoid colon diverticulum using the ultrathin endoscope. The patient was a 71‐year‐old man who experienced rebleeding after hemostasis in the sigmoid colon by endoscopic band ligation. In the case of diverticular bleeding in the sigmoid colon, we showed that identifying exposed blood vessels by observing the diverticulum under direct vision using the ultrathin endoscope may be useful for hemostasis.
The in‐hospital administration of sacubitril/valsartan in acute myocardial infarction: A meta‐analysis
Authors: Di Pietro Gianluca , Improta Riccardo , Severino Paolo , D'Amato Andrea , Birtolo Lucia Ilaria , De Filippo Ovidio , Lattanzio Antonio , De Cristofaro Raffaele , Galardo Giacchino , D'Ascenzo Fabrizio , Badagliacca Roberto , Sardella Gennaro , Volterrani Maurizio , Fedele Francesco , Vizza Carmine Dario , Mancone Massimo 
Published: October 2024

AbstractThere is a need to address the evidence gap regarding the in‐hospital administration of sacubitril/valsartan in acute myocardial infarction patients. After searching MEDLINE, Google Scholars and Scopus, a random‐effects meta‐analysis of randomized controlled trials comparing the in‐hospital administration of the angiotensin receptor‐neprilysin inhibitors (ARNis) versus the standard therapy in patients with reduced heart failure due to myocardial infarction was performed. The primary outcome was major adverse cardiovascular events. All‐cause mortality, cardiac death, rehospitalization for heart failure, non‐fatal myocardial infarction (MI), changes in left ventricular ejection fraction, left ventricular volumes, N terminal pro brain natriuretic peptide and adverse events were the secondary endpoints. Nine studies (eight randomized controlled trials and one echo‐substudy) with a total 6597 individuals (angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker: 3300 patients vs. ARNis: 3297 patients) were included for quantitative analysis. Median follow‐up was 6 months. Patients receiving an in‐hospital coadministration of ARNi had a lower risk of major cardiovascular event [odds ratio (OR) 0.45, 95% confidence interval (CI) 0.32–0.63, P < 0.0001] and lower rate of repeat rehospitalization for heart failure (OR 0.40, 95% CI 0.26–0.62, P < 0.0001), compared with a standard regimen. Additionally, left ventricle volumes were significantly lower in the ARNi group [left ventricular end‐diastolic volume, mean difference (MD) 11.48 mL, 95% CI 6.10–16.85, P < 0.0001; left ventricular end‐systolic volume, MD 7.09 mL, 95% CI 2.89–11.29, P = 0.0009] with a significant change in left ventricular ejection fraction (MD 3.07, 95% CI 1.61–4.53, P < 0.0001), compared with standard therapy. No significant differences were observed in terms of cardiac death, all cause of mortality, non‐fatal myocardial infarction and N terminal pro brain natriuretic peptide. Higher rates of iatrogenic hypotensive events were observed in the ARNi group compared with the standard therapy (OR 1.42, 95% CI 1.26–1.60, P value < 0.00001). In patients with acute myocardial infarction related heart failure, the in‐hospital administration of ARNis was associated with a reduced risk of major cardiovascular events and re‐hospitalization for heart failure, as well as cardiac remodelling, but higher rates of hypotensive events compared with standard therapy.
Left atrial function in uraemic patients: Four‐dimensional automatic left atrial quantitative technology study
Authors: Li Bing , Chen Meihua , Huang Xuning 
Published: October 2024

AbstractObjectiveThis study aimed to evaluate the utility of left atrial volume and function in uraemic patients using four‐dimensional automatic left atrial quantification (4D auto LAQ) technology.MethodsThirty‐four undialysed uraemic patients (U‐ND group), 60 dialysed uraemic patients (U‐D group), and 32 healthy volunteers (N group) were enrolled in our current study. Conventional echocardiographic parameters were recorded, and left atrial volume and strain parameters were analysed to determine statistical differences among the three groups. The Pearson correlation coefficient was employed to assess the relationships between left atrial ejection fraction and left atrial strain parameters.ResultsCompared to the N group, uraemic patients often displayed left atrial enlargement and left ventricular hypertrophy. Significant increases were noted in left atrial diameter, interventricular septum thickness, left ventricular posterior wall thickness, E/e′, diastolic blood pressure, systolic blood pressure, left atrial minimum volume, left atrial maximum volume, left atrial pre‐atrial contraction volume, left atrial emptying volume and left atrial maximum volume index (P < 0.05). Conversely, the e′, E/A ratio and left atrial reservoir longitudinal strain were significantly decreased (P < 0.05). However, no statistically significant differences were observed in the aforementioned parameters between the U‐ND and U‐D groups. The absolute values of left atrial conduit longitudinal strain and left atrial conduit circumferential strain, as well as left atrial passive ejection fraction, were notably lower in the U‐D group compared to the N and U‐ND groups, with statistically significant differences identified among the three groups (P < 0.05).ConclusionsUraemic patients exhibit marked left atrial enlargement and left ventricular hypertrophy, coupled with altered atrial function, particularly ductal dysfunction in the U‐D group. The 4D auto LAQ technology proves advantageous in detecting these alterations, offering a promising tool for thorough cardiac assessment in this patient cohort.
Heterogenization of a Sandwich [(PW9O34)2Co4(H2O)2]10− in PCN‐222/PCN‐222(M): Exploring the Electron Transfer for Electrocatalytic CO2 Reduction
Authors: Shu Lei , Li Can , Peng Meng‐Ting , Liu Meng‐Jie , Teng Yun‐Lei , Dong Bao‐Xia 
Published: October 2024

AbstractIn this study, we designed and prepared polyoxometalate@metal‐organic framework (POM@MOF) composite catalysts through the anchoring of a sandwich POM [(PW9O34)2Co4(H2O)2]10− (shortened as P2W18Co4) to the hexagonal channel of the PCN‐222 (metal‐free) or PCN‐222(M) (M=Fe, Co) frameworks. The composite materials were applied to the electrocatalytic reduction of CO2 reaction (CO2RR) to analyse the effect of incorporating P2W18Co4 on catalytic activity. The P2W18Co4@PCN‐222 composite exhibited enhanced activity across a wide potential range (−0.60~−0.85 V vs. RHE) and an optimal FECO of 72 % at −0.75 V vs. RHE, which was more than double that of PCN‐222 (FECO=33 %). The current density surpassed that of the PCN‐222 precursors by over sixteen times at the same potential. In contrast, the P2W18Co4@PCN‐222(M) composite demonstrated decreased current density, minimal enhancement in CO2RR activity, and a competing HER behaviour. Density functional theory calculations were conducted on simplified models of P2W18Co4@H2‐TCPP and P2W18Co4@M‐TCPP to elucidate the divergent catalytic performances. The findings revealed that while both configurations exhibited the same rate‐limiting step (formation of the *COOH intermediate), a significantly reduced reaction barrier was only observed in the P2W18Co4@H2‐TCPP setup, explaining its substantial activity improvement.
Cage Architecture and Reactivity are Preserved in Cysteine‐Mutated Ferritin
Authors: Cosottini Lucrezia , Buzzigoli Jacopo , Turano Paola 
Published: October 2024

AbstractThe role of solvent‐exposed cysteines as reactive sites for bioconjugation with a variety of metal drugs or fluorescent probes is emerging in the use of human H‐ferritin (HuHf) as a nanocarrier for targeting various tumor cell lines. Here, we have investigated the role of these residues in controlling the structural stability and ferroxidase activity by analyzing the properties of three variants: C90A, C90AC102A, and C130A. Protein folding and cage assembly were unchanged. Ferroxidase activity was also unaffected, indicating that these cysteines are not involved in either the catalytic activity or the overall iron(II) uptake process. For comparison, activity measurements were also performed on two derivatives involving the solvent‐exposed cysteine residues.
Copper‐Mediated Decarboxylative Trifluoromethylselenolation of Alkynyl Carboxylic Acids with [Me4N][SeCF3]
Authors: Ding Xue , Yao Yu‐Fei , Li Jiang‐Yu , Zhang Cheng‐Pan 
Published: October 2024

AbstractThe synthesis of alkynyl trifluoromethyl selenoethers from copper‐mediated aerobic decarboxylative trifluoromethylselenolation of alkynyl carboxylic acids with [Me4N][SeCF3] is reported. The reaction proceeded smoothly under mild conditions and enabled the facile conversion of both aryl and alkyl alkynyl carboxylic acids to the corresponding trifluoromethyl selenoethers in good yields, demonstrating that decarboxylative trifluoromethylselenolation of alkynyl carboxylic acids with the nucleophilic [Me4N][SeCF3] reagent is feasible at ambient temperature without irradiation. Advantages of the method include the use of bench‐stable and non‐volatile alkynyl carboxylic acids as starting materials, readily accessible SeCF3 reagent, excellent functional group tolerance, and the avoidance of harsh reaction conditions. This copper‐mediated reaction represents the first decarboxylative trifluoromethylselenolation of alkynyl carboxylic acids with a SeCF3 source.
Diazo‐Based Construction of Heterocyclic Systems Via a X−H Insertion/Cyclization Cascade
Authors: Malkova Ksenia , Dar'in Dmitry 
Published: October 2024

AbstractThe X−H insertion reaction (X=heteroatom) of diazo compounds has emerged as an eminent and reliant approach for the construction of C−X bonds. By merging X−H insertion with the sequential ring‐closing transformations, diverse heterocyclic systems can be obtained in a step‐economical manner. In recent years, the X−H insertion/cyclization cascades and one‐pot transformations attract more research attention, especially in the area of asymmetric synthesis. Concentrating on the assembly of N,O,S‐heterocycles, this Concept elucidates the various combinations of X−H insertion reactions with cyclization via an addition to multiple bonds. The ring‐forming strategies reviewed comprise of Michael‐type and Conia‐ene reactions, aldol condensation, and Mannich reaction.
Syntheses and Properties of Two Isomeric Phenanthroacephenanthrylene Derivatives
Authors: Sharma Priyank Kumar , Babbar Akanksha , Sahewal Sakshi , Das Soumyajit 
Published: October 2024

AbstractCyclopenta‐annulated polycyclic aromatic hydrocarbons (CP‐PAHs) are of significant interest due to their unique optoelectronic properties and applications in organic electronic devices. Phenanthroacephenanthrylene (PAP) isomers are CP‐PAHs that have been rarely investigated, and only the [9,10‐e]PAP isomer was explored to date. Herein, we report the syntheses, crystal structure and optoelectronic properties of two PAP isomers, 7‐ethoxy[2,1‐e]PAP 1 and 9‐ethoxy[1,2‐e]PAP 2. The structural isomers were synthesized in multi‐steps, and structural elucidations were performed using NMR, mass, and single‐crystal X‐ray diffraction analyses, revealing planar backbone of the isomers. UV‐visible absorption and fluorescence spectra of compound 1 were red‐shifted than that of 2, suggesting smaller HOMO–LUMO energy gap which is further validated by DFT calculations that suggested the lowering of HOMO–LUMO spacing could be attributed to the greater destabilization of HOMO for 1.
Entropy‐Based Assessment of Biodiversity, With Application to Ants' Nests Data
Authors: Altieri L. , Cocchi D. , Ventrucci M. 
Published: October 2024

ABSTRACTThe present work takes an innovative point of view in the study of a marked point pattern dataset of two ants' species, over an irregular region with a spatial covariate. The approach, based on entropy measures, brings new insights to the interpretation of the behavior of such ants' nesting habits, which can be exploited in the general area of biodiversity evaluation. We make proper use of descriptive entropy measures and inferential approaches, performing a comparative study of their uncertainty and interpretability in the context of biodiversity. For the first time in the study of these ants' nests data, all the available information is fully exploited, and interpretation guidelines are given for assessing both the observed and the latent biodiversity of the system, with a simultaneous consideration of spatial structures, covariate and interpoint interaction effects. Computations are supported by the new release of our R package SpatEntropy.