bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histopathology and Long-Term Outcome of Kidneys Transplanted From Donors With Severe Acute Kidney Injury
Authors: Cima Luca , Nacchia Francesco , Ghimenton Claudio , Valotto Giovanni , Boschiero Luigino , Gobbo Stefano , Zaza Gianluigi , Neil Desley , Mescoli Claudia , Vanzo Francesca , D’Errico Antonietta , Ghimenton Caterina , Rugge Massimo , Casartelli-Liviero Marilena , Brunelli Matteo , Novelli Luca , Eccher Albino 
Published: December 2018

Background: Acute kidney injury is a treatable entity although difficult to recognize without diagnostic biopsy. We investigated the potential association between clinically defined deceased donors and acute kidney injury with preimplantation histological findings and recipient outcomes. Methods: Kidney biopsies from donors were classified using the Acute Kidney Injury Network criteria and assessed for percentage glomerulosclerosis, tubular atrophy, interstitial fibrosis, and vascular narrowing with the Remuzzi score and for acute tubular necrosis. Differences in incidence rates of delayed graft function (DGF) and cumulative rejection episodes were compared between recipients transplanted with normal and 3 levels of acute kidney injury using the analysis of variance with Bonferroni correction ( P = .0012). Results: Sixteen out of 335 donors showed a severe acute kidney injury level 3 with a median serum creatinine of 458 µmol/L. Fourteen (88%) had 0-3 Remuzzi score and were used for single kidney transplantation and 2 (12%) were used for dual kidney transplantation (score: 4-6). Recipients who received a kidney from a donor with level 3 acute kidney injury had a higher percentage of DGF (47%) without statistical significance ( P = .008). The rate of cumulative rejection (45%) at 2 years was not significantly increased ( P = .09). Conclusions: Recipients receiving level 3 acute kidney injury kidneys, selected with Remuzzi histopathological score and acute tubular necrosis assessment, had a greater incidence of DGF but a similar long-term cumulative rejection compared to no injury and level 1 and level 2 acute kidney injury donors. The application of the histopathological examination allowed expansion of the kidney donor pool.
Association of renal artery stenosis with left ventricular remodeling in patients coexisting with renovascular and coronary artery disease
Authors: Dong Haojian , Ou Yanqiu , Nie Zhiqiang , Huang Wenhui , Liu Yuan , Zhou Yingling , Luo Jianfang , Li Guang 
Published: December 2018

Objective Data about renal artery stenosis association with left ventricular remodeling in patients coexisting with coronary artery disease are scanty. Methods Patients with suspected both coronary artery disease and renal artery stenosis undergoing coronary and renal arteriography between October 2013 and December 2015 were prospectively enrolled. Left ventricular remodeling patterns were compared among different severity of renal artery stenosis group. Logistic regression was done to investigate the determinants of the left ventricular morphology. Results The overall prevalence of left ventricular hypertrophy was 40.5%, the highest in bilateral renal artery stenosis group compared to unilateral or normal ones (65.4% versus 41.8% versus 34.8%, p = 0.012). Significantly lower estimated glomerular filtration rate and higher cystatin C level were found in bilateral renal artery stenosis group than that in other two groups. Multivariate regression analysis showed that bilateral renal artery stenosis was associated with increased left ventricular hypertrophy and concentric hypertrophy with statistical significance (adjusted odds ratio = 2.909 (95%CI: 1.063–7.961), and 3.021 (95%CI: 1.136–8.033)). In addition, estimated glomerular filtration rate level was also related to left ventricular hypertrophy, while there was no significant interaction between renal artery stenosis and coronary artery disease on left ventricular hypertrophy/concentric hypertrophy occurrence. Conclusions Bilateral renal artery stenosis is significantly associated with increased left ventricular hypertrophy/concentric hypertrophy in patients with suspected concomitant coronary and renal artery disease, while no synergic effect could be found in coronary artery disease.
Development of a step counting algorithm using the ambulatory tibia load analysis system for tibia fracture patients
Authors: Lajevardi-Khosh Arad , Tresco Ben , Stuart Ami , Sinclair Sarina , Ackerman Matt , Kubiak Erik , Petelenz Tomasz , Hitchcock Robert 
Published: December 2018

Introduction: Ambulation can be used to monitor the healing of lower extremity fractures. However, the ambulatory behavior of tibia fracture patients remains unknown due to an inability to continuously quantify ambulation outside of the clinic. The goal of this study was to design and validate an algorithm to assess ambulation in tibia fracture patients using the ambulatory tibial load analysis system during recovery, outside of the clinic. Methods Data were collected from a cyclic tester, 14 healthy volunteers performing a 2-min walk test on the treadmill, and 10 tibia fracture patients who wore the ambulatory tibial load analysis system during recovery. Results The algorithm accurately detected 2000/2000 steps from simulated ambulatory data. During the 2-min walk test, step counts derived from the algorithm and treadmill showed a strong correlation (r 2 >0.98) to the visual (“actual”) step count. Applying the algorithm to continuous data from tibia fracture patients revealed qualitative differences in gait between the initial and later stages of recovery. Additionally, a relatively large standard deviation (≤3000 steps) in the daily average step count indicated a variety of patient ambulatory behaviors. Conclusion The algorithm reported in this study can assess the ambulatory activity of tibia fracture patients during the recovery period.
Nonfocal transient neurological attacks in patients with carotid artery occlusion
Authors: Oudeman Eline A , Volkers Eline J , Greving Jacoba P , Klijn Catharina JM , Algra Ale , Kappelle L.Jaap 
Published: December 2018

Introduction Nonfocal transient neurological attacks (TNAs) are episodes with atypical, nonlocalizing cerebral symptoms. We examined the prevalence of nonfocal TNAs, in patients with and without carotid artery occlusion (CAO). Methods We included 67 patients with CAO and 62 patients without CAO. In both groups, patients had a history of transient ischemic attack (TIA) or nondisabling ischemic stroke in the anterior circulation that had occurred >6 months before inclusion. Patients without CAO did not have ipsilateral or contralateral carotid artery stenosis of ≥50%. All patients were interviewed with a standardized questionnaire on the occurrence of nonfocal TNA symptoms during the preceding six months. We calculated risk ratios (RRs) with 95% confidence intervals (CIs) for the occurrence of ≥1 and ≥2 different nonfocal TNAs after adjustments for age, sex, systolic blood pressure and time interval between most recent TIA or ischemic stroke and administration of the questionnaire. Results Forty-three of all patients (33%) had had one or more nonfocal TNAs in the preceding six months. Nonrotatory dizziness (24%) was reported most often. The prevalence of ≥1 nonfocal TNAs was not significantly different between patients with and without CAO (39% vs. 27%; adjusted RR 1.47, 95% CI 0.83–2.61), but the prevalence of ≥2 or more different nonfocal TNAs was higher in patients with CAO (16% vs. 3%; adjusted RR 4.77, 95% CI 1.20–18.98). In patients with CAO who also had a contralateral carotid or vertebral artery steno-occlusion, nonfocal TNAs occurred more often than in patients without any carotid or vertebral artery steno-occlusion (46% vs. 27%; adjusted RR 2.22, 95% CI 1.08–4.60 for ≥1 and 21% vs. 3%; adjusted RR 8.27, 95% CI 1.83–37.32 for ≥2 nonfocal TNAs). Conclusions Patients with CAO more often experienced multiple nonfocal TNAs than patients without CAO.
Obinutuzumab pretreatment abrogates tumor lysis risk while maintaining undetectable MRD for venetoclax + obinutuzumab in CLL
Authors: Kater Arnon P. , Kersting Sabina , van Norden Yvette , Dubois Julie , Dobber Johan A. , Mellink Clemens H. , Evers Ludo M. , Croon-de Boer Fransien , Schreurs John , van der Spek Ellen , Visser Hein , Idink Cecile , Wittebol Shulamiet , Hoogendoorn Mels , Tonino Sanne H. , Mobasher Mehrdad , Levin Mark-David 
Published: December 2018

Abstract
Early data on venetoclax-containing regimens for the treatment of chronic lymphocytic leukemia (CLL) show promising results with deep remissions, but are hampered by potential risk for tumor lysis syndrome (TLS). Whether optimal duration of venetoclax treatment can be guided by minimal residual disease (MRD) is currently unknown. To study whether TLS risk can be mitigated in an unfit population by introducing preinduction, and whether MRD-guided duration of venetoclax treatment is a feasible and efficacious approach, we performed the Dutch-Belgian Cooperative Trial Group for Hemato-oncology (HOVON) 139/GIVE trial. The study treatment consists of 4 treatment phases: preinduction (2 cycles obinutuzumab), induction I (6 cycles obinutuzumab and venetoclax), induction II (6 cycles venetoclax), and a randomization phase (group A: maintenance with 12 additional cycles of venetoclax irrespective of MRD; group B: MRD guided venetoclax maintenance with a maximum of 12 cycles). Here we report on a planned interim safety analysis as well as preliminary efficacy and MRD data of the first 30 patients enrolled. Downgrading of TLS risk after preinduction occurred in 25 patients: 3 from high to medium, 3 from high to low, and 19 from medium to low risk. No patient remained high risk. From these 30 patients, peripheral blood MRD data were obtained for 28 patients at the end of induction II (6 months after the last obinutuzumab dose), of whom 26 had undetectable MRD levels, and for 18 patients who reached the 3-month after-randomization point, of whom 16 had undetectable MRD levels. Obinutuzumab preinduction is tolerated well in these unfit patients and results in abrogating high TLS risk in all patients. Preliminary data indicate that efficacy is maintained with a high proportion of patients with undetectable MRD levels after combination treatment.
Unraveling inter-species differences in hagfish slime skein deployment
Authors: Bernards Mark A. , Schorno Sarah , McKenzie Evan , Winegard Timothy M. , Oke Isdin , Plachetzki David , Fudge Douglas S. 
Published: December 2018

ABSTRACTHagfishes defend themselves from fish predators by producing defensive slime consisting of mucous and thread components that interact synergistically with seawater to pose a suffocation risk to their attackers. Deployment of the slime occurs in a fraction of a second and involves hydration of mucous vesicles as well as unraveling of the coiled threads to their full length of ∼150 mm. Previous work showed that unraveling of coiled threads (or ‘skeins’) in Atlantic hagfish requires vigorous mixing with seawater as well as the presence of mucus, whereas skeins from Pacific hagfish tend to unravel spontaneously in seawater. Here, we explored the mechanisms that underlie these different unraveling modes, and focused on the molecules that make up the skein glue, a material that must be disrupted for unraveling to proceed. We found that Atlantic hagfish skeins are also held together with a protein glue, but compared with Pacific hagfish glue, it is less soluble in seawater. Using SDS-PAGE, we identified several soluble proteins and glycoproteins that are liberated from skeins under conditions that drive unraveling in vitro. Peptides generated by mass spectrometry of five of these proteins and glycoproteins mapped strongly to 14 sequences assembled from Pacific hagfish slime gland transcriptomes, with all but one of these sequences possessing homologs in the Atlantic hagfish. Two of these sequences encode unusual acidic proteins that we propose are the structural glycoproteins that make up the skein glue. These sequences have no known homologs in other species and are likely to be unique to hagfishes. Although the ecological significance of the two modes of skein unraveling described here are unknown, they may reflect differences in predation pressure, with selection for faster skein unraveling in the Eptatretus lineage leading to the evolution of a glue that is more soluble.
Borocarbonitrides, BxCyNz, 2D Nanocomposites with Novel Properties
Authors: Rao C N R , Pramoda K 
Published: December 2018

Abstract
Chemical doping of graphene is necessary to generate a band gap that is valuable for a range of applications. Chemical doping of graphene with elements like nitrogen and boron gives rise to useful properties. In this context, recent studies of borocarbonitrides, BxCyNz, comprising carbon, and the two elements on either side of it, are of significance. While uniformly homogeneous compositions of borocarbonitrides may be hard to generate, there have been efforts to synthesize them by solid state as well as gas phase routes. The products obtained show evidence for the presence of B-C and C-N bonds besides B-N and C-C bonds (but no N-N bonds), and possible occurrence of random BCN networks in addition to graphene and BN domains. Properties of borocarbonitrides depend on the composition, and the method of synthesis, enabling one to traverse from the insulating BN to the conducting graphene. In this account, we present important features of borocarbonitrides including synthesis, characterization, properties and potential applications. Surface oxygen functionalities and amine-groups of borocarbonitrides have been quantitatively determined by the fluorescence labeling of surface species (FLOSS) technique. Typical applications are in gas adsorption and energy devices such as supercapacitors and fuel cells as well as electrochemical sensors. Performance of borocarbonitrides as a HER catalysts is impressive, showing electrochemical activity close to that of Pt. It is possible to covalently link a BCN layer to other 2D nanosheets and the materials obtained by such cross-linking with layers of C3N4, MoS2 and MoSe2 show outstanding HER performance and other useful characteristics. Interestingly, heterostructures of BCN with nanosheets of MoS2 and other 2D materials can be formed reversibly by supramolecular means, which show good visible-light driven photochemical hydrogen evolution activity.
Transcription factor binding site clusters identify target genes with similar tissue-wide expression and buffer against mutations
Authors: Lu Ruipeng , Rogan Peter K. 
Published: December 2018

Background:The distribution and composition ofcis-regulatory modules composed of transcription factor (TF) binding site (TFBS) clusters in promoters substantially determine gene expression patterns and TF targets. TF knockdown experiments have revealed that TF binding profiles and gene expression levels are correlated. We use TFBS features within accessible promoter intervals to predict genes with similar tissue-wide expression patterns and TF targets.Methods:Genes with correlated expression patterns across 53 tissues and TF targets were respectively identified from Bray-Curtis Similarity and TF knockdown experiments. Corresponding promoter sequences were reduced to DNase I-accessible intervals; TFBSs were then identified within these intervals using information theory-based position weight matrices for each TF (iPWMs) and clustered. Features from information-dense TFBS clusters predicted these genes with machine learning classifiers, which were evaluated for accuracy, specificity and sensitivity. Mutations in TFBSs were analyzed toin silicoexamine their impact on cluster densities and the regulatory states of target genes.Results: We initially chose the glucocorticoid receptor gene (NR3C1), whose regulation has been extensively studied, to test this approach.SLC25A32andTANKwere found to exhibit the most similar expression patterns toNR3C1. A Decision Tree classifier exhibited the largest area under the Receiver Operating Characteristic (ROC) curve in detecting such genes. Target gene prediction was confirmed using siRNA knockdown of TFs, which was found to be more accurate than those predicted after CRISPR/CAS9 inactivation.In-silicomutation analyses of TFBSs also revealed that one or more information-dense TFBS clusters in promoters are required for accurate target gene prediction. Conclusions: Machine learning based on TFBS information density, organization, and chromatin accessibility accurately identifies gene targets with comparable tissue-wide expression patterns. Multiple information-dense TFBS clusters in promoters appear to protect promoters from effects of deleterious binding site mutations in a single TFBS that would otherwise alter regulation of these genes.
Occlusal Splints for Bruxing and TMD – A Balanced Approach?
Authors: Jagger Robert , King Elizabeth 
Published: December 2018

Occlusal splints are classified in this article into three groups according to the way that opposing teeth contact the splint: 1) partial occlusal contact; 2) full occlusal contact in retruded arc of closure; and 3) full occlusal contact in protrusion. Each type of splint has relative advantages and disadvantages. Splints do not reliably or predictably reduce bruxism and there are differences between individuals in their response to the wearing of splints. When treating temporomandibular disorders, splints should be provided as part of a package of conservative physiotherapy type measures. There is no evidence that any one type of splint is most effective. Long-term wearing of designs that may lead to permanent occlusal changes should be avoided or the patient should be carefully monitored for occlusal changes. CPD/Clinical Relevance: The article describes the effect of splints on bruxism. Advice is provided on best practice in respect of the use of splints in the management of temporomandibular disorders.
Perspective and the Infinite in the Early Modern Age
Authors: Pavlovits Tamás 
Published: December 2018

The thematic section of this issue consists of two parts: translations of two texts by Pascal on mathematics and four essays on different interpretations of the infinite in the Early Modern Age. The translations and the essays have emerged from the OTKA research “Perspective and Epistemology in the Early Modern Age,” linked to the research activity of the “The Philosophy of the Early Modern Age” workshop (KUFIM).
The essays in the second part are extended versions of the papers of the conference organized by KUFIM at Eötvös Loránd University (ELTE) Budapest on May 11, 2011. I would like to thank Gábor Nagy, associate professor of mathematics at the Bolyai Institute of the University of Szeged, for his generous help with the translations. The translations have used the texts and notes of Jean Mesnard’s critical edition of Pascal (1970). The thematic issue has been supported by two OTKA projects: K 81165 and K 67798.
Teológiai fenomenológia és a metafizika meghaladása. Jean-Luc Marion – kartezianizmus, fenomenológia, teológia
Authors: Herczegh Máté 
Published: December 2018

Theological phenomenology and the transgression of metaphysics. Jean-Luc Marion: Cartesianism, Phenomenology, Theology. (Review)

Takács Ádám – Camilleri, Sylvain (eds.): Jean-Luc Marion, Cartesianism, Theology. Budapest, Gondolat, 2012.
Leibniz and Law: An Overview of the Legal Dimension of Leibnitz’s Oeuvre and its Current Critical Reception
Authors: Paksy Máté 
Published: December 2018

The paper expounds the legal relevance of Leibniz’ work through the lens of Leibniz’ contemporary reception. The bulk of the paper focuses on early legal work by Leibniz and some popular later texts like Monadology or Discourse from the perspective of legal issues.
The first part of the paper introduces Leibniz as a student of law and as a young lawyer. Then it compares three philosophers’ readings of Leibniz to find out if/how they considered his legal background. Next it portrays Leibniz as a classic advocate of natural law. This view refutes the possibility of reading his thinking as political theology. Finally, contemporary readings of Leibniz are surveyed that focus on the relevance of his early legal writing.
Sponte sua
Authors: Kállay Géza 
Published: December 2018

Tengelyi László műveiben a Husserlre, Merleau-Pontyra és követőire alapozott fenomenológia diakritikus módszerével a jelenségeket a tudatban kívánja megragadni és értelmezni. Az értelmezett jelenség az élmény terminust kapja. Az uralhatatlan, spontán – sponte sua – értelemképződésnek Tengelyi a tapasztalat elnevezést adja. A tapasztalat révén valami új keletkezik a tudatban. Ez a történetmondás egy lehetséges modellje is lehet, hiszen az értelemadás gyakran egy történetben lehetséges számunkra, legyen az a történet bármilyen rövid és egyszerű is.
Jelen tanulmányban a spontán értelemképződés (tapasztalat) és tematikus értelemadás diakritikus feszültségét Shakespeare Macbethjének történetmodelljén át mutatjuk be. Macbeth tragédiáját Tengelyi elméletének fényében úgy értelmezzük, hogy a darab során Macbeth voltaképpen ennek a spontánul képződő, hirtelen, kívülről támadó jelenésnek az értelmezésére törekszik, miközben a darab valamiképpen a Vészlények irányítása alatt álló, tényleges cselekménye ezzel állandó, folyamatos veszteségeket felvonultató feszültségben bontakozik ki.
Physical Properties and Wear Comfort of Bio-Fiber-Embedded Yarns and their Knitted Fabrics According to Yarn Structures
Authors: Hyun Ah Kim , Seung Jin Kim 
Published: December 2018

Abstract
This study examined the physical properties of polytrimethylene terephthalate (PTT)/Tencel/cotton air vortex yarns and the wear comfort of their knitted fabrics for high emotional garments. In fine yarn count, the initial modulus of the air vortex yarn was similar to the ring yarn because of the elastic property of the PTT fibers in the yarns. In particular, the thermal shrinkage of the air vortex yarns was higher than that of the ring yarns because of the sensible thermal shrinkage of the PTT fibers, which resulted in higher relaxation shrinkage of the air vortex knitted fabric than those of ring and compact knitted fabrics. On the basis of the wear comfort, the air vortex yarns are compatible with winter textile goods. The pilling of the air vortex knitted fabric was superior to that of the ring and compact yarns. The tactile hand of the air vortex yarn knitted fabrics was stiffer than that of the ring and compact yarn knitted fabrics. However, the harsh tactile hand of the air vortex knitted fabric was estimated to improve in the thinner fabrics by the low elastic modulus of fine yarn because of the PTT fibers in the air vortex yarns.
High sensitivity, contemporary and point-of-care cardiac troponin assays: educational aids developed by the IFCC Committee on Clinical Application of Cardiac Bio-Markers
Authors: Collinson Paul O. , Saenger Amy K. , Apple Fred S. ,   on behalf of the IFCC C-CB
Published: December 2018

AbstractThe International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) formed a Task Force on the Application of Cardiac Bio-markers (TF-CB) in 2008, re-designated in 2018 as a committee (C-CB), to produce educational materials on cardiac biomarkers. Established in June 2017, definitive tables covering the majority of high-sensitivity, contemporary and point-of-care (POC) cTn assays have been developed by the C-CB and are available on the IFCC website. These tables provide extensive information about assays’ analytical characteristics and encompass information on diagnostic discriminants, particularly the 99th percentiles, as provided by the manufacturers.