bluuebunny/crossref_metadata_2025_split huggingface dataset:
VARIANTS AND PERSPECTIVES OF DRUG REPURPOSING FOR CANCER TREATMENT
Authors: Savinkova A. V. , Zhidkova E. M. , Tilova L. R. , Lavrova M. D. , Lylova E. S. , Kuzin K. A. , Portyannikova A. Yu. , Maximova V. P. , Kholodova A. V. , Vlasova O. A. , Fetisov T. I. , Kirsanov K. I. , Belitskiy G. A. , Yakubovskaya M. G. , Lesovaya E. A. 
Published: July 2018

Recently many new approaches for repurposing or repositioning of the clinically used drugs have been developed. Drug repurposing allows not only to use known schemes for the synthesis of biologically active compounds, but also to avoid multiple studies that are necessary for drug approval process – analysis of pharmacokinetics, carcinogenicity, acute and chronic toxicity, including cardiotoxicity, nephrotoxicity, allergenicity etc. It makes possible to reduce the number of experimental studies as well as costs of investigations. In cancer research drug repurposing includes screening for medicines used nowadays for the treatment of patients with non-cancer diseases which possess anticancer activity or able to enhance the effects of the standard anticancer chemotherapy, and search for new applications of known anticancer drugs for the treatment of different cancer types. Scientific rationale for the search of the compounds with potential anticancer properties among drugs with different applications is based on the multiple cross-talks of signaling pathways, which can inhibit cell proliferation. Modern advances in genomics, proteomics and bioinformatics, development of permanently improving databases of drug molecular effects and high throughput analytical systems allow researchers to analyze simultaneously a large bulk of existing drugs and specific molecular targets. This review describes the main approaches and resources currently used for the drug repurposing, as well as a number of examples.
Nitrogen Rate and Mowing Height Affect Seasonal Performance of Zoysiagrass Cultivars
Authors: Schwartz Brian , Zhang Jing , Kenworthy Kevin , Miller Grady , Peacock Charles , Sladek Bradley , Christensen Christian 
Published: July 2018

Core Ideas
Nitrogen rate had a greater impact on turfgrass quality of zoysiagrass when the grass was actively growing, but the effect of mowing height was only significant during spring green‐up.
Nitrogen rate of 171 kg ha−1 was suitable for consistent turf performance in zoysiagrass and the effect of increasing N rate from 171 to 268 kg per ha was minimal.
Japanese lawngrass and manilagrass can be successfully maintained at 2.5 or 5.0 cm and 0.6 or 1.2 cm, respectively, for equivalent performance during the majority of the year; however, during spring green‐up, the lower mowing height may deliver better turf performance.
As new zoysiagrass (Zoysia spp.) cultivars are released, field studies on N responses and mowing heights conducted over several years under different environments are needed to determine best management practices. This study was initiated to (i) characterize a general response (color, density, turf quality) to N fertilization rate, mowing height, and their interactions among zoysiagrass cultivars; and (ii) establish appropriate mowing height and N rate recommendations for each of the cultivars studied. Four Japanese lawngrass cultivars (Z. japonica Steud.) and four manilagrass cultivars (Z. matrella L. Merr.) were evaluated in Citra, FL, for 4 yr and in Raleigh, NC, for 2 yr under three N rates (73, 171, and 268 kg ha−1 yr−1) and two mowing heights (2.5 and 5.0 cm for Japanese lawngrass; 0.6 and 1.2 cm for manilagrass). Genetic differences were evident among the zoysiagrass cultivars. Nitrogen rate had a greater impact on most of the observed characteristics when the grass was actively growing, but the effect of mowing height was only significant during spring green‐up. The medium N rate was suitable for consistent turf performance throughout the year and the effect of increasing N rate from 171 kg ha−1 to 268 kg ha−1 was minimal. Japanese lawngrass and manilagrass can be successfully maintained at 2.5 or 5.0 cm and 0.6 or 1.2 cm, respectively, for equivalent performance during the majority of the year. However, during spring green‐up, the lower mowing height may deliver better turf performance.
El software educativo Hot Potatoes en el aprendizaje de la especialidad de computación en el Centro de Educación Técnica Productiva “Virgen del Rosario” de Huari, Perú (The Hot Potatoes educational software in the learning of the computer science program in the Technical Productive Education Center “Virgen del Rosario” in Huari, Peru)
Authors: Dávila Rojas Oscar Melanio 
Published: July 2018

El estudio partió de la preocupación por encontrar métodos y estrategias idóneas para mejorar el aprendizaje de los estudiantes y que estos adquieran habilidades necesarias para su desempeño eficaz y eficiente en las diferentes exigencias que plantean la sociedad y la vida. Tuvo como objetivo general determinar la influencia del software educativo Hot Potatoes en el aprendizaje de la especialidad de Computación en los estudiantes del Centro de Educación Técnica Productiva “Virgen del Rosario” de Huari. Es de tipo aplicada y se desarrolló con un enfoque cuantitativo, alcance descriptivo y diseño pre-experimental, con preprueba-posprueba y un solo grupo. Se realizó en una muestra (no probabilística intencional) de 31 estudiantes de la especialidad de Computación, cuyas edades estaban entre los 10 y 50 años. El instrumento utilizado fue una prueba de selección múltiple compuesta por 20 ítems. Esta fue validada por cinco especialistas, con una calificación promedio de 87,1% ysu fiabilidad se verificó con el coeficiente de confiabilidad de Küder-Richardson que dio Cf = 0.659 (muy confiable). La Prueba t de Student indicó una diferencia muy significativa (p = 0.000), entre el pre test y el post test de la prueba de Computación, concluyéndose que el uso del software educativo Hot Potatoes influye significativamente en el aprendizaje de los estudiantes de la especialidad de Computación del Centro de Educación Técnica Productiva “Virgen del Rosario” de Huari, Perú.
Características del uso de emojis en la comunicación por el chat de Whatsapp (Characteristics in the use of emojis in the communication through WhatsApp Chat)
Authors: Montenegro Díaz Denis José 
Published: July 2018

La presente investigación tuvo como objetivo general determinar las características del uso de emojis en la comunicación en el chat de Whatsapp, en función de aspectos sociodemográficos, prevalencia de uso e interpretaciones personales. Para tal fin se realizó un análisis estadístico descriptivo cuantitativo, con la finalidad de identificar las principales características manifestadas por usuarios de Whatsapp en el uso de emojis en el chat de conversación. La recolección de datos se llevó a cabo mediante un diseño exploratorio. Con este fin, se aplicó una encuesta web de 22 ítems, validado por juicio de expertos con una valoración promedio 80.90%. La encuesta se difundió en redes sociales entre el 30 de enero al 28 de febrero del 2018. La muestra fue no probabilística, con un total de 222 usuarios de Whatsapp, procedentes de diferentes países, con edad promedio entre 18 a 50 años. Los resultados mostraron que el 56.8% de personas que usaron los emojis en el chat de Whatsapp eran mujeres yel 43.2% varones. Así mismo, se encontró que el 29.7% fueron estudiantes y el 21.2% docentes, todos ellos universitarios. En cuanto al uso de los emojis se halló que los de mayor uso fueron el que llora de risa, el sorprendido, el pensativo, el de ataque de risa y del beso. Las interpretaciones que los usuarios hicieron de los emojis fue muy diversa, puesto que el significado dependió de la asimilación del sentido visual que cada uno de ellos le asignó al emoji.
La independencia judicial en el Perú en crisis según los estándares del Sistema Interamericano de Derechos Humanos
Authors: López Alfonsín Marcelo , Salerno Luciana 
Published: July 2018

Este artículo pretende analizar las medidas provisionales dictadas por la Corte Interamericana de Derechos Humanos en el caso Durand y Ugarte vs. Perú a la luz de los estándares interamericanos en materia de independencia judicial y división de poderes con el objetivo de reflexionar sobre la situación de Perú ante el Sistema Interamericano de Derechos Humanos.
A comparative estimate of climate change impacts on cotton and maize in Greece
Authors: Voloudakis Dimitrios , Karamanos Andreas , Economou Garyfalia , Kapsomenakis John , Zerefos Christos 
Published: July 2018

Abstract
The impact of climate change on cotton and maize was estimated on the basis of three IPCC Emission Scenarios (A1B, A2, B2) for seven main agronomic areas during three periods, 1961–1990, 2021–2050 and 2071–2100. All climate models were assessed for their ability to identify the yield differences through the standardized discriminant function coefficients. Discriminant analysis was performed for each period. For cotton, using the A1B scenario, areas of Western Greece exhibited the most favourable results in terms of yield increase, compared to other regions, ranging up to the maximum value of +24%. This tendency became more pronounced towards the end of the century reaching an increase of +31%. In the A2 scenario, all the areas had a positive impact on their yield change rising up to 30% in areas of central Greece. A positive change for all regions was observed for scenario B2 ranging from +10% to +25%. In maize, the scenario A1B produced small changes in yields, not exceeding 5%. For A2 scenario, yield change varied from −5.7% to +3.6%. Scenario B2 gave more optimistic estimates of yield changes towards the end of the century, in some cases exceeding 5%.
Формирование системы профессиональных компетенций специалистов в вузе
Authors: Макарова Елена Александровна , Макарова Елена Львовна 
Published: July 2018

In the modern educational environment it is necessary to form system social, cultural, professional компетенций which will allow developing necessary corporate culture, social freedom, the attitude to the chosen trade at new generation of experts. The analysis of a developing situation brings to necessity of changes for the technology of the professional training sold in sphere of education, and changes in representations about the most educational system. Development of system professional competences should become a part of long-term policy of educational system. Psychologists, teachers and methodologists should unite e熭orts to direct to formation of the multifunctional didactic system directed on intellectual development of the individual which occurs on the basis of subject knowledge.
Chromatographic and Surfactant Based Potentiometric Determination of Aqueous Dissociation Constant of Mupirocin
Authors: Nakov Natalija , Brezovska Katerina , Karchev Vasil , Acevska Jelena , Dimitrovska Aneta 
Published: July 2018

Background:
The available data concerning aqueous dissociation constant of mupirocin
(sparingly soluble drug) are scarce. In this study, chromatographic, surfactant based potentiometric
concept and spectrophotometric method were used for determination of the aqueous pKa value of
mupirocin.

Methods:
Different approaches were used for estimation of the aqueous pKa value from the apparent
pKa values obtained at four ACN concentrations, ranging from 22% to 30%. The potentiometric determination
of the pKa value of mupirocin was performed using different concentration of Tween 80 as
a surfactant.

Results:
The aqueous pKa value of mupirocin, determined for the first time by reverse-phase liquid
chromatography method, was found to be 4.76. The obtained value was confirmed by potentiometric
method (4.85). It was found that Tween 80 increases the pKa values. The linear relationship between
the apparent pKa values and the surfactant concentrations was used as an approach for estimation
of the aqueous pKa value. Both methods gave similar values for aqueous pKa
which correspond
with the theoretically obtained pKa value (4.88) using Pallas computer program. It was found that
mupirocin gives pH-indipendent spectra, thus spectrophotometric method is not applicable for determination
of pKa of this compound.

Conclusion:
This comprehensive approach used for the pKa determination enable us to obtained reliable
results for the aqueous pKa value of mupirocin. The linear relationship between the pKa values and
the nonionic surfactant concentrations could be used as a reliable and simple approach for determination
of aqueous pKa value of sparingly soluble drugs.
Black Hole Attack Detection in Healthcare Wireless Sensor Networks Using Independent Component Analysis Machine Learning Technique
Authors: Clement Sunder A. John , Shanmugam A. 
Published: July 2018

Background:
Wireless Sensor Networks (WSNs) are self-configured infrastructure-less
networks are comprising of a number of sensing devices used to monitor physical or environmental
quantities such as temperature, sound, vibration, pressure, motion etc. They collectively transmit
data through the network to a sink where it is observed and analyzed.

Materials and Methods:
The major issues in WSN are interference, delay and attacks that degrade
their performance due to their distributed nature and operation. Timely detection of attacks is imperative
for various real time applications like healthcare, military etc. To improve the Black hole
attack detection in WSN, Projected Independent Component Analysis (PICA) technique is proposed
herewith, which detects black hole attack by analyzing collected physiological data from
biomedical sensors.

Results:
The PICA technique performs attack detection through Mutual information to measure
the dependence in the joint distribution. The dependence among the nodes is identified based on
the independent probability distribution functions and mutual probability function.

Conclusion:
The black hole attack isolation is then performed through the distribution of the
attack separation message. This supports to improve Packet Delivery Ratio (PDR) with minimum
delay. The simulation is carried out based on parameters such as black hole attack detection rate
(BHADR), Black Hole Attack Detection Time (BHADT), False Positive Rate (FPR), PDR and delay.
How to be Successful in Football: A Systematic Review
Authors: Lepschy Hannes , Wäsche Hagen , Woll Alexander 
Published: July 2018

Background:Despite the popularity of football, the analysis of success factors in football remains a challenge. While reviews on performance indicators in football are available, none focuses solely on the identification of success factors and addresses the large and growing body of recent research up until 2016.Objective:To find out what determines success in football and to organize the body of literature, a systematic literature review analyzing existing studies with regard to success factors in football was undertaken.Methods:The studies included in this review had to deal with performance indicators related to success in football. The studies were published in 2016 or before. The initial search revealed 19,161 articles. Finally, sixty-eight articles were included in this review. The studies were clustered with regard to comparative analyses, predictive analyses and analyses of home advantage.Results:In total, 76 different variables were investigated in the reviewed papers. It appeared that the most significant variables are efficiency (number of goals divided by the number of shots), shots on goal, ball possession, pass accuracy/successful passes as well as the quality of opponent and match location. Moreover, new statistical methods were used to reveal interactions among these variables such as discriminant analysis, factor analysis and regression analysis. The studies showed methodological deficits such as clear operational definitions of investigated variables and small sample sizes.Conclusion:The review allows a comprehensive identification of critical success factors in football and sheds light on utilized methodological approaches. Future research should consider precise operational definitions of the investigated variables, adequate sample sizes and the involvement of situational variables as well as their interaction.
Low Noise and Low Distortion Telescopic OTA for Biomedical Signal Processing
Authors: Patel Zuber M. 
Published: July 2018

Background:
This paper presents a low noise and low distortion telescopic Operational
Trans-conductance Amplifier (OTA) that is suited to biomedical signal processing. In our proposal,
source degeneration using CMOS transmission gate is introduced in telescopic OTA to realize current-
voltage negative feedback. The negative feedback degenerates Gm, reduces flicker noise and reduces
distortion.

Methods:
The circuit is simulated by using TSMC 90nm CMOS process technology with 1.8V supply
voltage. We obtained promising simulation results that show THD less than -90dB and flicker
noise 60 nV at 4kHz corner frequency.

Results:
The frequency response plot reveals that our circuit offers a voltage gain of 63dB with negative
feedback and achieves a phase margin of about 70 degrees. Thus, this topology is a feasible solution
for low noise and low distortion biomedical signal amplifier circuits.

Conclusion:
A highly linear and low noise telescopic OTA topology was proposed in this paper. A
simple but efficient technique of source degeneration is used with negative feedback to achieve low
distortion and low noise.
Risk Factors for the Development of Low Quality of Life in Adults with Juvenile Idiopathic Arthritis
Authors: Dzhus Marta 
Published: July 2018

Juvenile idiopathic arthritis is known to persist into adulthood which is associated with the development of a large number of long-term consequences, including low quality of life. The objective of the research was to evaluate quality of life in young adults with juvenile idiopathic arthritis and to analyze the risk factors for the development of its low level using the 36-Item Short Form Health Survey. Materials and methods. There were examined 135 adult patients with juvenile idiopathic arthritis without severe comorbidity at the age of 18 to 40 years and 25 apparently healthy young adults of the same age and gender. Quality of life was evaluated using the 36-Item Short Form Health Survey. Results. In patients with juvenile idiopathic arthritis, the physical health score (44.8±9.9) was lower (p=0.001) as compared to healthy individuals (55.7±6.9). Patients with juvenile idiopathic arthritis had lower indicators of physical functioning (p=0.001), role functioning (p=0.001) and bodily pain (p=0.001) than healthy individuals. However, in patients with juvenile idiopathic arthritis, the indicators of the mental health score and associated vitality, social functioning, role limitations due to emotional problems and mental health did not differ from those in the control group. Prolonged morning stiffness (p<0.05) and polyarticular variant of joint damage (p<0.05) were the risk factors for the development of low physical health score in young adults with juvenile idiopathic arthritis. According to the articular juvenile arthritis damage index (p<0.001), the presence of long-term articular damage was associated with high physical health score. There were found no risk factors for the development of low mental health score. Conclusions. Young adults with juvenile idiopathic arthritis at the age of 18 to 40 years had worse quality of life than healthy individuals of the same age and gender. They had worse physical well-being scores including physical functioning, role functioning and bodily pain. The risk factors for the development of low physical health score in young adults with juvenile idiopathic arthritis were the presence of prolonged morning stiffness as a manifestation of disease activity and polyarticular variant of joint damage, while the presence of prosthetic joints improved their physical health score.
Histomorphological Effects of Nicotine on Selected Parts of the Brain of Adult Wistar Rats
Authors: Oyem John Chukwuma , Odokuma Emmanuel Igho 
Published: July 2018

Nicotine has been defined as a potent parasympathomimetic alkaloid that accumulates in the roots and leaves of Nightshade family of plants Aim: This study was aimed at evaluating the effects of orally ingested nicotine in the histology of hippocampus, substantia nigra and cerebellum.Materials and Methods: Twenty four adult male Wistar rats (100g – 200g) were randomly divided into 4 groups (group 1 – group 4). Group 1 served as the control group, while groups 2 - 4 were the treated groups. Nicotine was diluted in water and 1ml of the different dosage (2mg/kg/day, 4mg/kg/day and 6mg/kg/day) were administered to the treated groups respectively with the aid of orogastric cannula for 42 days. Animals were euthanized by cervical dislocation at the end of 7, 21 and 42 days so as to demonstrate the dose and time dependant effect of this agent. Brain tissues were harvested, processed and stained using Haematoxylin and eosin according to standard histological techniques. Stained tissue images were captured using digital micrometer eyepiece and cell count was determined using stereological technique.Statistical analysis: Data obtained were subjected to statistical analysis with the use of statistical package for social sciences (SPSS version 20). Significant differences were obtained using One Way Analysis of Variance with a probability of 0.05 (95% confidence limit) and Tukeys post hoc test was further used to determine the mean significant differences between specific groups.Results: Histological findings showed mild, moderate and severe hyperplasia in a dose and time dependant manner. However, observations from quantitative analysisalso revealed a dose and time dependant significant increase in neuronal cell count and cell diameter of the hippocampus, Substantia nigra and cerebellum.Conclusion: This study has demonstrated that oral exposure of Nicotine in rats display proliferative adaptive changes on the hippocampus, substantia nigra and cerebellum in a dose/time dependent manner.
Dental and Somatic Pathology Comoridity in Children
Authors: Hodovanets Oksana , Pavlov Jurij , Grynkevych Ljudmyla , Vitkovskyj Oleksandr 
Published: July 2018

The aim of the research is to study the dental status of children with concomitant somatic pathology, to establish the interrelated correlations.To reach the aim the clinical observation of 460 12-15-year-old children was conducted: I group – children with chronic gastroduodenitis (90 people); II – children with dystonia (100); III – children with chronic diseases of the upper respiratory tract (90 people); IV – children with diabetes type 1 (80), V – children with diffuse nontoxic goiter (100 people). Dental status of children was assessed by the indices OHI-S, PMA, CPI, prevalence and intensity of dental caries (DMF - Decayed, Missing, Filled), non-carious lesions of dental hard tissues and dentoalveolar anomalies and deformities. Conclusions. The highest intensity and prevalence of dental caries and periodontal tissue diseases is observed in case of gastroenterological pathology (96.7 and 90.0%, respectively). Dental caries complications are often observed in children with diabetes mellitus (62.5%) and diseases of the gastrointestinal tract (44.4%). Dentofacial anomalies and deformities mostly occur in children with endocrinopathy (66% approximately). Poor oral hygiene, as well as the percentage of carious and extracted teeth in the DMF index structure indicates the need to improve dental care for these children.Development of prevention and treatment differentiated methods of children with concomitant somatic and dental pathology is promising.