bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal Changes and Regional Variation in Acceptance of Hepatitis C Virus–Viremic Livers
Authors: Mazur Rafal D. , Goldberg David S. 
Published: September 2019

The high efficacy of current hepatitis C virus (HCV) therapy and increased numbers of HCV‐infected deceased donors have changed the paradigm of HCV in liver transplantation (LT). Modeling studies have been performed to evaluate the optimal timing of HCV treatment (before versus after LT) in HCV‐infected patients and to assess the cost‐effectiveness of transplanting HCV‐infected livers into HCV− patients. However, these models rely on historical data and have not quantified the temporal changes in the median Model for End‐Stage Liver Disease (MELD) score at transplant of recipients of an HCV‐infected liver across geographic areas. We performed a retrospective cohort study of Organ Procurement and Transplantation Network/United Network for Organ Sharing (UNOS) data of nonstatus 1 deceased donor LT recipients from January 1, 2016, to December 31, 2018, and we calculated the difference in allocation MELD score in recipients of HCV nucleic acid test (NAT)− versus NAT+ livers by year and UNOS region. We used Pearson correlation coefficients to assess the relationship between MELD score difference in recipients of HCV NAT+ versus HCV NAT− livers and the proportion of non‐HCV recipients of HCV NAT+ livers. Nationally, the allocation MELD score difference at LT in recipients of HCV NAT+ versus NAT− livers did not change (4‐point difference). This stability was seen in regions 3, 5, and 10. In regions 1, 7, 8, 9, and 11, the MELD score difference decreased, which is a diminishing advantage. However, in regions 2 and 4, it increased, which is a rising advantage. In 2018, recipients of HCV NAT+ livers had a lower MELD score in 9/11 regions, and the MELD score advantage of accepting HCV NAT+ livers had a moderate inverse correlation with the regional use in non‐HCV patients (r = −0.53). These data should be used to inform clinicians of the pre‐ and post‐LT trade‐offs of HCV treatment.
Continuation of multiple power series in a sectorial domain
Authors: Mkrtchyan A. J. 
Published: September 2019

AbstractFor multiple power series centered at the origin we consider the problem of its analytic continuability into a sectorial domain. The condition for continuability is formulated in terms of a holomorphic function that interpolates the series coefficients. For series in one variable this problem has been studied in the works of E. Lindelöf, N. Arakelian, and others.
The effect of metal oxide on the cure, morphology, thermal and mechanical characteristics of chloroprene and butadiene rubber blends
Authors: Smejda-Krzewicka Aleksandra , Olejnik Anna , Strzelec Krzysztof 
Published: September 2019

Abstract
This paper discusses the role of metal oxides (MeO) in the cross-linking process and useful properties of chloroprene and butadiene rubber (CR/BR) blends. Iron(III) oxide (Fe2O3), iron(II,III) oxide (Fe3O4), silver(I) oxide (Ag2O) or zinc oxide were used. It has found that every proposed metal oxide can be used as a cross-linking agent of the CR/BR blends. The degree of cross-linking was evaluated by means of vulcametric parameters, equilibrium swelling in selected solvents and Mooney–Rivlin elasticity constants. The properties of the cured CR/BR products, such as tensile strength, stress at elongation, tension set under constant elongation and compression set, were also investigated. The results revealed that all CR/BR/MeO vulcanizates were characterized by a high cross-linking degree and satisfying mechanical properties. The most important advantage of obtained rubber goods is very high resistance to flame. The increase in the oxygen index value for the CR/BR/Fe2O3, CR/BR/Fe3O4 and CR/BR/Ag2O vulcanizates compared to the standard cross-linked chloroprene rubber showed that presented metal oxides provided a positive effect on the resistance to flame of the new CR/BR/MeO composites. Satisfactory properties of the studied blends are related to the presence of the interelastomer bonding of both rubbers in the compositions.
Three-dimensional elasticity analysis of sandwich panels with functionally graded transversely isotropic core
Authors: Woodward B. , Kashtalyan M. 
Published: September 2019

Abstract
In this paper, three-dimensional elastic deformation of rectangular sandwich panels with functionally graded transversely isotropic core subjected to transverse loading is investigated. An exponential variation of Young’s and shear moduli through the thickness is assumed. The approach uses displacement potential functions for transversely isotropic graded media and a three-dimensional elasticity solution for a transversely isotropic graded plate developed by the authors. The effects of transverse shear modulus, loading localisation, panel thickness and anisotropy on the stresses and displacements in the panel are examined and discussed.
A Pilot Study of Smartphone-Based Memory Bias Modification and Its Effect on Memory Bias and Depressive symptoms in an Unselected Population
Authors: Visser Damian A. , Tendolkar Indira , Schene Aart H. , van de Kraats Livia , Ruhe Henricus G. , Vrijsen Janna N. 
Published: September 2019

AbstractMemory bias modification (MBM) is a relatively new approach at targeting biased processing—a central cognitive factor causing and maintaining depression. In this pilot study we aimed to develop a smartphone-based autobiographical memory training, a novel form of MBM. A total of 153 unselected participants were randomly allocated to one of three experimental training conditions (positive, negative or sham memory training) conducted over a period of three days. Autobiographical memory bias and depressive scores were assessed pre- and post-training, whilst recent event recall and explicit self-referent memory bias were assessed post-training. Positive memory bias significantly increased in the positive training condition, however memory bias did not significantly differ post-training between the three conditions. Participants who received positive training recalled a positive autobiographical event more frequently compared to the other conditions. No significant difference between conditions was found in the other outcomes, including symptoms. The novel smartphone-based MBM intervention seems apt to affect autobiographical memory of emotional material. Future research should explore its possible (therapeutic) application.
The anti-ethylene growth regulator silver thiosulfate (STS) increases flower production and longevity in cassava (Manihot esculenta Crantz)
Authors: Hyde Peter T. , Guan Xian , Abreu Viviane , Setter Tim L. 
Published: September 2019

Abstract
Cassava, which produces edible starchy roots, is an important staple food for hundreds of millions of people in the tropics. Breeding of cassava is hampered by its poor flower production, flower abortion, and lack of reproductive prolificacy. The current work determined that ethylene signalling affects floral development in cassava and that the anti-ethylene plant growth regulator silver thiosulfate (STS) mitigates the effects of ethylene on flower development. STS did not affect the timing of flower initiation, but improved early inflorescence and flower development as well as flower longevity such that flower numbers were increased. STS did not affect shoot and storage root growth. Studies of silver accumulation and treatment localization support the hypothesis that the beneficial effects of STS are confined to tissues of the shoot apex. The most effective timing of application was before inflorescence appearance extending to post-flower appearance. Based on this work a recommended protocol for STS use was developed. This work has the potential to improve methods for enhancing cassava flower development in breeding nurseries and thereby synchronize flowering of desired parents and enable the production of abundant progeny of desired crosses.
Improved strategy for isoleucine 1H/13C methyl labeling in Pichia pastoris
Authors: Ali Rustam , Clark Lindsay D. , Zahm Jacob A. , Lemoff Andrew , Ramesh Karthik , Rosenbaum Daniel M. , Rosen Michael K. 
Published: September 2019

Abstract
Site specific methyl labeling combined with methyl TROSY offers a powerful NMR approach to study structure and dynamics of proteins and protein complexes of high molecular weight. Robust and cost-effective methods have been developed for site specific protein 1H/13C methyl labeling in an otherwise deuterated background in bacteria. However, bacterial systems are not suitable for expression and isotope labeling of many eukaryotic and membrane proteins. The yeast Pichia pastoris (P. pastoris) is a commonly used host for expression of eukaryotic proteins, and site-specific methyl labeling of perdeuterated eukaryotic proteins has recently been achieved with this system. However, the practical utility of methyl labeling and deuteration in P. pastoris is limited by high costs. Here, we describe an improved method for 1H/13C-labeling of the δ-methyl group of isoleucine residues in a perdeuterated background, which reduces the cost by ≥ 50% without compromising the efficiency of isotope enrichment. We have successfully implemented this method to label actin and a G-protein coupled receptor. Our approach will facilitate studies of the structure and dynamics of eukaryotic proteins by NMR spectroscopy.
How climate change might affect tree regeneration following fire at northern latitudes: a review
Authors: Boucher Dominique , Gauthier Sylvie , Thiffault Nelson , Marchand William , Girardin Martin , Urli Morgane 
Published: September 2019

Abstract
Climate change is projected to increase fire severity and frequency in the boreal forest, but it could also directly affect post-fire recruitment processes by impacting seed production, germination, and seedling growth and survival. We reviewed current knowledge regarding the effects of high temperatures and water deficits on post-fire recruitment processes of four major tree species (Picea mariana, Pinus banksiana, Populus tremuloides and Betula papyrifera) in order to anticipate the effects of climate change on forest recovery following fire in the boreal biome. We also produced maps of future vulnerability of post-fire recruitment by combining tree distributions in Canada with projections of temperature, moisture index and fire regime for the 2041–2070 and 2071–2100 periods. Although our review reveals that information is lacking for some regeneration stages, it highlights the response variability to climate conditions between species. The recruitment process of black spruce is likely to be the most affected by rising temperatures and water deficits, but more tolerant species are also at risk of being impacted by projected climate conditions. Our maps suggest that in eastern Canada, tree species will be vulnerable mainly to projected increases in temperature, while forests will be affected mostly by droughts in western Canada. Conifer-dominated forests are at risk of becoming less productive than they currently are, and eventually, timber supplies from deciduous species-dominated forests could also decrease. Our vulnerability maps are useful for prioritizing areas where regeneration monitoring efforts and adaptive measures could be developed.
Affirmation and Denial in Aristotle’s De interpretatione
Authors: Perälä Mika 
Published: September 2019

AbstractModern logicians have complained that Aristotelian logic lacks a distinction between predication (including negation) and assertion, and that predication, according to the Aristotelians, implies assertion. The present paper addresses the question of whether this criticism can be levelled against Aristotle’s logic. Based on a careful study of theDe interpretatione, the paper shows that even if Aristotle defines what he calls simple assertion in terms of predication, he does not confound predication and assertion. That is because, first, he does not understand compound assertion in terms of predication, and secondly, he acknowledges non-assertive predicative thoughts that are truth-evaluable. Therefore, the implications of Aristotle’s ‘predication theory of assertion’ are not as devastating as the critics believe.
Artificial neural networks as a tool for pattern recognition and electrofacies analysis in Polish palaeozoic shale gas formations
Authors: Puskarczyk Edyta 
Published: September 2019

AbstractUnconventional oil and gas reservoirs from the lower Palaeozoic basin at the western slope of the East European Craton were taken into account in this study. The aim was to supply and improve standard well logs interpretation based on machine learning methods, especially ANNs. ANNs were used on standard well logging data, e.g. P-wave velocity, density, resistivity, neutron porosity, radioactivity and photoelectric factor. During the calculations, information about lithology or stratigraphy was not taken into account. We apply different methods of classification: cluster analysis, support vector machine and artificial neural network—Kohonen algorithm. We compare the results and analyse obtained electrofacies. Machine learning method–support vector machine SVM was used for classification. For the same data set, SVM algorithm application results were compared to the results of the Kohonen algorithm. The results were very similar. We obtained very good agreement of results. Kohonen algorithm (ANN) was used for pattern recognition and identification of electrofacies. Kohonen algorithm was also used for geological interpretation of well logs data. As a result of Kohonen algorithm application, groups corresponding to the gas-bearing intervals were found. Analysis showed diversification between gas-bearing formations and surrounding beds. It is also shown that internal diversification in gas-saturated beds is present. It is concluded that ANN appeared to be a useful and quick tool for preliminary classification of members and gas-saturated identification.
A Multinational European Study of Patient Preferences for Novel Diagnostics to Manage Antimicrobial Resistance
Authors: Mott David J. , Hampson Grace , Llewelyn Martin J. , Mestre-Ferrandiz Jorge , Hopkins Michael M. 
Published: September 2019

Abstract

Background
Novel diagnostics are needed to manage antimicrobial resistance (AMR). Patient preferences are important in determining whether diagnostic tests are successful in practice, but there are few data describing the test attributes which matter most to patients. We elicited patients’ preferences for attributes of diagnostic tests that could be used to reduce unnecessary antibiotic use in primary care across seven European countries.

Methods
We used an online stated preference survey, including a discrete choice experiment (DCE). The DCE explored how patients make trade-offs between three key attributes of diagnostic tests: the speed that results were available, confidence in the test results, and how convenient it is to take the test. Individuals were eligible to complete the survey if they had taken antibiotics within the last 2 years and were resident in Germany, Italy, Spain, France, Greece, the Netherlands or the United Kingdom (UK).

Results
In total, 988 respondents completed the survey. The DCE responses illustrated that speed was the least important attribute in most countries. Responses from Germany and the Netherlands indicated that confidence was most important in these countries. Responses from the UK, France, Spain and Italy showed convenience as the most important attribute in these countries. Two attributes, confidence and convenience, were jointly favoured by respondents in Greece.

Conclusion
Patients in different European countries do not have the same preferences for the attributes of diagnostic tests to manage AMR in primary care. Failure to account for such differences during test development could reduce test uptake, result in continued overuse of antibiotics, and hamper marketisation.
The many ways to hack 2FA
Authors: Grimes Roger 
Published: September 2019

As the days of pervasive password authentication are starting to wane, administrators and end users are increasingly turning to stronger types of authentication such as two-factor authentication (2FA) and multi-factor authentication (MFA). All other considerations considered equal, MFA solutions (which include 2FA) are usually stronger than single-factor authentication (1FA) solutions such as the ubiquitous duo of username and password. This is generally agreed upon by all computer security professionals. People are increasingly turning to stronger types of authentication such as two-factor authentication (2FA) and multi-factor authentication (MFA). But somewhere along the way, many people have come to associate MFA solutions with being far less hackable or even unhackable. Nothing could be further from the truth. In fact, it's possible to use nothing more than a simple phishing email to easily bypass many beloved MFA solutions, says Roger Grimes of KnowBe4.
Best practices for fighting the fileless threat
Authors: Baldin Andy 
Published: September 2019

In their continuous quest to find new tools, techniques and tactics to outsmart the white hats, hackers have hit upon a pretty effective strategy. Fileless malware attacks are on the rise, but we still have to worry about file-based approaches, making for a complex situation for defenders. Fileless malware attacks are on the rise, but we can't afford to overlook existing threats, creating a complex situation for defenders. The answer lies with a back-to-basics approach based around some key cyber hygiene processes such as patch management and app control, layered up to maximise prevention and minimise risk. With a good foundation in place, expanding to include detection and response can now be done successfully, argues Andy Baldin of Ivanti.
CAEP 2018 Academic Symposium: Recommendations for developing and supporting Global Emergency Medicine in Canadian academic emergency departments and divisions
Authors: Collier Amanda , Marton Gregory , Chun Shannon , Nijssen-Jordan Cheri , Bartels Susan A. , Pulfrey Simon , Lang Eddy , Schull Michael , Landes Megan , Johnson Kirsten 
Published: September 2019

ABSTRACTObjectivesThe objective of the CAEP Global Emergency Medicine (EM) panel was to identify successes, challenges, and barriers to engaging in global health in Canadian academic emergency departments, formulate recommendations for increasing engagement of faculty, and guide departments in developing a Global EM program.MethodsA panel of academic Global EM practitioners and residents met regularly via teleconference in the year leading up to the CAEP 2018 Academic Symposium. Recommendations were drafted based on a literature review, three mixed methods surveys (CAEP general members, Canadian Global EM practitioners, and Canadian academic emergency department leaders), and panel members’ experience. Recommendations were presented at the CAEP 2018 Academic Symposium in Calgary and further refined based on feedback from the Academic Section.ResultsA total of nine recommendations are presented here. Seven of these are directed towards Canadian academic departments and divisions and intend to increase their engagement in Global EM by recognizing it as an integral part of the practice of emergency medicine, deliberately incorporating it into strategic plans, identifying local leaders, providing tangible supports (i.e., research, administration or financial support, shift flexibility), mitigating barriers, encouraging collaboration, and promoting academic deliverables. The final two recommendations pertain to CAEP increasing its own engagement and support of Global EM.ConclusionsThese recommendations serve as guidance for Canadian academic emergency departments and divisions to increase their engagement in Global EM.
Homer and his Legacy in Gregory of Nazianzus’ ‘On his own Affairs’
Authors: O’Connell Peter A. 
Published: September 2019

AbstractThis paper investigates how Gregory of Nazianzus imitates and responds to the Greek literary tradition in the autobiographical poem ‘On his own affairs’ (2.1.1). Through six case studies, it contributes to the ongoing re-evaluation of Gregory’s literary merit. With learning, wit, subtle humour and faith, Gregory adapts and reinvents earlier poetry to express Christian themes. Imitation is at the heart of his poetic technique, but his imitations are never straight-forward. They include imitating both Homer and other poets’ imitations of Homer, learned word-play and combining references to non-Christian literature and the Septuagint. Gregory’s references add nuance to ‘On his own affairs’ and give pleasure to readers trained to judge poetry by comparing it to earlier poetry, especially the Homeric epics. They also demonstrate the breadth of his scholarship, which extends to Homeric variants, Platonic epigrams and the entirety of the New Testament and Septuagint. Above all, Gregory insists that he is a rightful participant in a living poetic tradition. He writes Greek poetry for the fourth century AD, just as Oppian did in the second century and Apollonius and Callimachus did in the Hellenistic period.
The validation of the Malay Yale Food Addiction Scale 2.0: factor structure, item analysis and model fit
Authors: Swarna Nantha Yogarabindranath , Kalasivan Ahalya , Ponnusamy Pillai Mahalakshmi , Suppiah Poopathy , Md Sharif Salmiah , Krishnan Shamini Gayathri , Samy Pullay Subasni , Osman Noor Ashikin 
Published: September 2019

AbstractObjective:The development of a second version of the Yale Food Addiction Scale (YFAS) coincides with the latest updates in the diagnosis of addiction as documented in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders. The objective of the present study was to translate the YFAS 2.0 into the Malay language and test its psychometric properties in a primary-care population.Design:Patients were assessed for food addiction utilizing the Malay YFAS 2.0. The participants were also assessed for eating disorder using the validated Malay Binge Eating Scale. The psychometric properties of the YFAS 2.0 were determined by analysing factor structure, overall item statistics, internal consistency and construct validity.Setting:Between 2017 and 2018, participants were chosen from a regional primary-care clinic in the district of Seremban, Malaysia.Participants:Patients (n 382) from a regional primary-care clinic.Results:The prevalence of food addiction was 5·0%. A two-factor structure of the YFAS was confirmed as the most optimal solution for the scale via confirmatory factor analysis. In both its diagnostic and symptom count version, the YFAS 2.0 had good internal consistency (Kuder–Richardson α > 0·80 and McDonald’s ω > 0·9).Conclusions:We validated a psychometrically sound Malay version of the YFAS 2.0 in a primary-care population. Both diagnostic and symptom count versions of the scale had robust psychometric properties. The questionnaire can be used to develop health promotion strategies to detect food addiction tendencies in a general population.