bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of Light Conditions and Root Nutrition Can Improve the Growth and Biosynthesis of Polyphenols in <em>Ocimum basilicum</em> L. Plants
Authors: Veremeichik Galina N. , Grigorchuk Valeria P. , Subbotin Evgenii P. , Kozhanov Sergei O , Tikhonova Olga A. , Brodovskaya Evgenia V. , Silantieva Slavena A , Subbotina Natalia I. , Yaroshenko Yulia L. , Bulgakov Victor P. , Kulchin Yurii N. 
Published: November 2024

The sweet basil Ocimum basilicum L. is the subject of numerous studies and is cultivated as a food and ornamental plant. Moreover, O. basilicum could be useful in the prevention of stroke ischaemia, and its anticancer properties were recently shown. The caffeic acid derivatives, such as rosmarinic acid (RA), chicoric acid, salvianolic acids, and anthocyanins provide medicinal properties of basil. Therefore, investigations of the optimal growth conditions that can provide cost-effective cultivation of highly productive basil plants are relevant and important. The aim of the present work was to study the effects of a combination of soil composition and light conditions on the morphological and biochemical characteristics of O. basilicum. In totally artificial (indoor) environments, light-emitting diodes (LEDs) may provide a broad range of narrowband wavelengths with different intensities. This technology can lower operating costs. In addition to the spectral composition, the light intensity (PPFD, µmol m-2s-1) is an important parameter for the optimal growth of plants. In the experiment, we used different light intensities of 300 µmol m-2s-1: warm white, monochromatic (green and red), and a combination of blue and red. Plants were grown under various lighting conditions in soil supplemented with fertilizer, Z-ion, and Crystallon. The results showed that supplementation of soil with Crystallon had a greater effect on the growth both above and below ground parts of O. basilicum plants. Interestingly, growing O. basilicum plants under R and RB light led to a 2-fold increase in the biosynthesis of both the key caffeic acid derivative RA and anthocyanin. However, given that under RB light, there is no positive effect of Crystallon on growth, the productivity of RA and anthocyanin reached a maximum when O. basilicum plants were grown under R light and Crystallon.
Understanding HIV-Related Mental Health Challenges and Contributing Factors Among Indonesian Adolescents Living with HIV
Authors: Ward Paul Russell , Puspitasari Reni , Rose Aasha , Gebremariyam Biniyam Sahiledengle , Fauk Nelsensius Klau 
Published: November 2024

HIV has disproportionately affected various population groups, including adolescents living with HIV (ALHIV). In many contexts, ALHIV have been reported to experience mental health issues following their HIV diagnosis. However, there is a limited understanding of the mental health issues faced by ALHIV in Indonesia and the various contributing factors globally. This study aimed to explore the mental health challenges and their contributing factors among Indonesian ALHIV. A qualitative design employing one-on-one in-depth interviews was used to collect data from ALHIV (n = 20) in Yogyakarta, Indonesia. Participants were recruited using the snowball sampling technique, beginning with the dissemination of study information sheets through a healthcare facility that provides HIV care services, and via a WhatsApp group for adolescents living with HIV. The data were thematically analysed, guided by a qualitative data analysis framework. The findings showed that ALHIV experienced a variety of mental health challenges upon learning of their HIV-positive status. Their mental health was also influenced by a range of family-related factors, stigma, and discrimination which were also facilitated by their specific situations and settings, including living in a shared house with parents and siblings, and school setting where they met and interacted with different peer groups on a daily basis. Family-related factors, including broken homes, family conflicts, lack of family support, and being orphans, negatively impacted their mental health. The awareness of perceived and anticipated stigma, and the experience of enacted stigma or discrimination, also contributed to the mental health challenges they faced. The findings indicate a pressing need for tailored and targeted HIV intervention programs and activities that support their mental health, reduce stigma, and promote HIV status disclosure in safe ways for ALHIV both within the study setting and beyond.
Stability Analysis of Excessive Carbon Dioxide Gas Emission Model Through Following Reforestation Policy in Low-Density Forest Biomass
Authors: Nezar Furqan , Jawad Shireen , Winter Matthias , Zeb Anwar 
Published: November 2024

بعتبر غاز ثاني أوكسيد الكاربون مسبب رئيسي لظاهرة الاحتباس الحراري. تعتبر الكتلة الحيوية للغابات ضرورية لاحتجاز ثاني أوكسيد الكاربون في الغلاف الجوي؛ ومع ذلك، فإن معدل الانخفاض في الكتلة الحيوية للغابات في جميع أنحاء العالم مثير للقلق ويمكن أن يعزى إلى الأنشطة البشرية. تعد إعادة التشجير أمرًا ضروريًا في هذه الحالة لتقليل كمية ثاني أوكسيد الكاربون في الغلاف الجوي. يمكن تقييم جهود إعادة التشجير وفقًا للاستثمار المالي المطلوب لتنفيذها. يقدم هذا العمل نموذجًا رياضيًا غير خطي يدرس تأثير إعادة التشجير وتنفيذ مبادرات إعادة التشجير على تنظيم مستويات غاز ثاني أوكسيد الكاربون في الغلاف الجوي. تم العثور على القيم الحرجة للنموذج وتم تحليل استقرارها . تم إجراء تحليل التشعب حول القيم الحرجة المحتملة. واستنادا إلى تحليل النموذج، فإن غياب إعادة التشجير من شأنه أن يعرض بعض الجوانب لخطر الانقراض. في حين ساهم برنامج اعادة التشجير في انخفاض مستوى ثاني أوكسيد الكاربون في الغلاف الجوي. علاوة على ذلك، يشير التحليل الرقمي إلى أن النظام يعاني من فقدان الاستقرار دون أنشطة إعادة التشجير.في حين يحافظ النظام على التذبذب من خلال تشعب هوبف أثناء الانخراط في أنشطة إعادة التشجير.
Analysis of Multiple Working Vacations Queuing System With Encouraged Arrival Using M/M (a,b)/1 Model
Authors: P Prakati , K. Julia Rose Mary 
Published: November 2024

تتناول هذه الدراسة مفهوم الوصول المشجع في نموذج قائمة الانتظار M/M(a,b)/1/MWV وتتبع القاعدة العامة للخدمة السائبة. يستمر الخادم في أخذ إجازة عندما يكون النظام خاملاً، أي عندما يكون فارغًا. يتعامل هذا النموذج مع إجازات العمل المتعددة التي يتم توزيعها بشكل كبير ويتم تقديم مفهوم الوصول المشجع في الفترة المزدحمة العادية. يعد مصطلح الوصول المشجع إضافة حديثة إلى المفاهيم الحالية لنظرية الانتظار لسلوك المستهلك ويتبع توزيع بواسون. تهدف هذه الدراسة إلى حساب متوسط طول قائمة الانتظار (Lq) ومقاييس الأداء الأخرى المختلفة لنموذج قائمة الانتظار الذي تمت مناقشته.
A Comparison of Anti-Citrullniated Peptide Antibody, Lactate Dehydrogenase, Zinc and Copper in Sera of Patients with Rheumatoid Arthritis and Healthy Control: A Cross Sectional Study
Authors: AL-Obaidy Fatima Qasim , Al-Gebori Abdulnasser M. , Alosami Mohammed Hadi Munshed 
Published: November 2024

المفاصل الروماتويدي (RA) هو مرض مناعي ذاتي جهازي مزمن يرتبط بتكاثر الأنسجة الزليلية وتكوين السبل. كان الغرض من هذه الدراسة هو تحديد العلاقة بين هذه العوامل ومستويات الأجسام المضادة للببتيد المضاد للسيترولين (ACPA)، والانزيم النازع لهيدروجين اللاكتات (LDH)، والزنك (Zn)، والنحاس (Cu) في مرضى التهاب المفاصل الروماتويدي (RA). أجريت الدراسة في مستشفى بغداد التعليمي في بغداد، العراق، وشارك فيها 110 مريضاً (95 أنثى و15 رجلاً)، الذين تمت مطابقتهم من حيث العمر والجنس مع 40 من الاشخاص الاصحاء(28 أنثى و12 ذكراً). تم تشخيص المرضى الذين يعانون من التهاب المفاصل الروماتويدي من قبل مجوعة اطباء الروماتيزم المتخصص باستخدام معايير ACR/EULAR في عام 2010. وفقًا لنوع العلاج المضاد للروماتيزم المُعدل للمرض المستخدم - البيولوجي (bDMARDs)، التقليدي (cDMARDs)، والمختلط (DMARDs) - .تم تقسيم المرضى في هذه الدراسة إلى ثلاث مجموعات فرعية. تم قياس كمية الزنك والنحاس وLDH باستخدام مقياس الطيف الضوئي (AAS)، في حين تم تقييم مصل ACPA باستخدام مقايسة الامتصاص المناعي المرتبط بالإنزيم (ELISA) أظهرت النتائج وجود ارتفاع ملحوظ في جميع المجموعات الفرعية لـ ACPAs (p<0.001)، الزنك (p<0.001)، والنحاس (p<0.001) بالمقارنة مع مجموعة الاشخاص الاصحاء ، ولكن لا توجد فروق ذات دلالة إحصائية بين المجموعات الفرعية. زادت مستويات LDH بشكل ملحوظ في المجموعات الفرعية للعلاج الكيميائي والعلاج الكيميائي الحيوي بالمقارنة مع الأصحاء، ولكن مستويات LDH انخفضت بشكل ملحوظ في المجموعة الفرعية للبيولوجيا بالمقارنة مع المجموعات الفرعية للعلاج الكيميائي والعلاج الكيميائي الحيوي. ليس لتغيير أنواع العلاج أي تأثير على رفع مستويات ACPA، والزنك، والنحاس، إلا أنه له تأثير على مستويات LDH لم تظهر المجموعة الفرعية للبيولوجيا أي فرق كبير بين المرضى والاشخاص الاصحاء.
Testing of Horizontal Wells With Overlying Gas Cap
Authors: Fleming C. H. , Gilman J. R. , Kazemi Hossein 
Published: November 2024

E&P Exchange
Pressure-buildup testing can be used to determine the need for remedial well treatment in horizontal wells. However, analysis of transient tests in these wells is complicated when a gas cap is present. In a fractured, vuggy, carbonate reservoir that contains a large gas cap, several buildup tests were run on horizontal wells. In almost all tests, the pressure derivative showed a period of oscillatory data in log-log plots (Fig. 1a), which shed doubt on the usefulness of the tests. This article provides an explanation of the oscillatory behavior and shows the conditions under which permeability and skin can be determined when a gas cap is present. Ref. 1 gives a more detailed discussion of results. Oscillations in the pressure derivative are often encountered in pressure-buildup tests as a result of measurement errors caused by the gauges. We initially thought this was the case in the tests studied until further investigation indicated multiphase effects. High-resolution electronic gauges with an accuracy of 0.01 psi were used on all the horizontal wells tested. Late-time data (at more than 2.5 hours) were not sampled as frequently as early data, resulting in an erratic appearance of the pressure derivative. However, careful examination of the derivative data shows continuous oscillatory behavior like that in the simulated case (Fig. 1b). The change in measured pressure between sampling intervals in the late-time data is well within the resolution of the gauge.
Rapid and intense onset of granulation tissue formation following walnut aspiration: A case report
Authors: Aykun Gökhan , Köseoğlu Handan İnönü 
Published: November 2024

Abstract

Foreign body aspiration can affect individuals of all ages and lead to symptoms such as dyspnea, coughing, and wheezing. Complications may arise from the physical and chemical properties of the aspirated material as well as the duration of retention. This case study reports the early bronchoscopic and pathological findings of a 38-year-old male patient who aspirated walnuts. The patient underwent flexible bronchoscopy 14 hours after aspiration, and a piece of walnut was successfully removed from the intermediate bronchus. During the procedure, the bronchial mucosa appeared extremely irregular and yellowish-green in color. Follow-up bronchoscopy one month later revealed regression of the previously observed granulation tissue. This case highlights the importance of early intervention in foreign body aspiration cases, especially with substances that can rapidly and intensely react with mucous membranes such as walnuts.
The impact of artificial intelligence on the new quality productive forces of enterprises
Authors: Xiaohong Chen , Liu Liu , Dayuan Li , Yangfan Han , Xiaoliang Liu 
Published: November 2024

Abstract

A new quality productive force is a strong driving and supporting force in the high-quality development of enterprises. It is thus crucial to study the driving factors underlying the development of enterprises. Using data on Chinese A-share listed companies from 2010 to 2022, this paper empirically analyzes the impact of artificial intelligence on the new quality productive forces of enterprises. It is found that (1) artificial intelligence significantly impacts the improvement of new quality productive forces of enterprises; (2) innovation-drivenness plays a mediating role in the relationship between artificial intelligence and the new quality productive forces of enterprises; (3) market competition plays a positive moderating role in the relationship between artificial intelligence and the new quality productive forces of enterprises; (4) compared with enterprises in central and western regions and enterprises with rigorous financing constraints, enterprises in eastern regions and those with liberal financing constraints can better improve new quality productive forces by utilizing artificial intelligence. These conclusions provide theoretical support for the use of artificial intelligence in improving new quality productive forces and enrich empirical research.
Establishment of a high-throughput scale-down clone screening platform for intensified fed-batch culture of CHO cells
Authors: Luo Haiyan , Wang Shuai , Chong Collin , Wang Lile , Sun Xiaojun , Guo Qian , Zhang Sam , Chen Xiaoyue , Zhou Hang , Zhou Weichang 
Published: November 2024

Abstract

Purpose
To develop a scale-down clone screening platform for the intensified fed-batch (IFB) process to allow efficient identification of high expressing clones fitting the IFB culture strategy in bioreactor.
Results
Three monoclonal antibodies (mAbs) were used in the development and validation of the IFB specific clone screening platform for CHO cells. The IFB platform significantly improved titer levels, achieving an average titer of 8 g/L and the highest titer of 9.6 g/L. With similar cell viability, lactate profile and titer levels, both the spin tube model and the AMBR250@ bioreactor system were effective in screening clones suitable for IFB process. The addition of aurintricarboxylic acid (ATA) and uridine in the process optimisation led to a further increase in expression levels in both systems, achieving the highest titer of 12.2g/L.
Conclusion
This IFB-process specific clone screening serves as an alternative platform that can increase the effectiveness and efficiency of screening high-expressing CHO cell lines for IFB production.
The cultural lanscape heritage sustainable strategy: integration of agricultural and tourism in Bali
Authors: Vipriyanti Nyoman Utari , Rustiarini Ni Wayan , Andayani Made Emy , Sedana Gede 
Published: November 2024

Abstract

The existence of the cultural landscape and Subak system in the Jatiluwih area has received recognition as a world cultural heritage from UNESCO (United Nation Educational, Science and Cultural organization). This recognition indicates a responsibility to preserve Subak, especially in agricultural areas that carry the concept of ecotourism. This study aims to describe the uniqueness and formulate a strategy for developing the subak cultural heritage area in Jatiluwih so that there can be inclusive and integrated development between agricultural and tourism activities. This research was conducted at the Jatiluwih world cultural heritage site using focus group discussions. The number of informants was 152 people from the management and members of the Jatiluwih Subak chosing purposively. This research used the analysis of Strengths, Weaknesses, Opportunities, Threats (SWOT) and Analytical Hierarchy Process (AHP). Strengths-based development strategies to increase opportunities can be implemented, such as improving the quality of attractions and services, managing natural potential, and developing tourist icons and tour packages. Meanwhile, development strategies with efforts to reduce threats were implemented, such as offering quality local products, developing local tourist attractions, increasing the role of key persons, and reducing the negative image of the village.
Age as a Non-Contraindication for Surgical Intervention in Patients with Abdominal Wall Incisional Hernia: An Exploration and Analysis
Authors: Huang Haonan , Ma Ning , Tang Fuxin , Zhou Taicheng 
Published: November 2024

Abstract

Background
Surgery is the only potential curative option in patients presenting with abdominal wall incisional hernia (IH). The approach clearly enhances patients' quality of life and reduces complications, however, the management of patients over 60 years old presents significant challenges, primarily due to the comorbidities and the complexities associated with postoperative recovery. The objective of this study was to examine postoperative outcomes in the age group over 60 years and the age group under 60 years.
Methods
The study included a retrospective analysis of all patients who underwent surgical treatment for IH between December 2018 and March 2023. The patient cohort was divided into two age groups: <60 years old and ≥ 60 years old. A comparison was made between the two groups in terms of baseline and intraoperative characteristics, as well as postoperative complications and recurrence
Result
During the study period, a total of 304 patients were enrolled, with 86 (28.3%) in the < 60 years age group and 218 (71.7%) in the ≥ 60 years age group. Baseline characteristics were comparable between the two groups, except for a higher prevalence of high blood pressure and ASA score among older patients. The intraoperative characteristics did not show any statistically significant differences between the two groups. The incidence of postoperative intestinal fistula and the 1-year recurrence rate were both zero in the < 60 years old group, indicating a complete absence of these complications. Apart from the duration of hospitalization, there was no statistically significant difference in postoperative outcomes between the two age groups. Notably, patients aged ≥ 60 years experienced a longer length of hospital stay (p = 0.009).
Conclusion
The postoperative complications and recurrence rate of patients with IH appear to be independent of age, thus advocating for surgical intervention regardless of the patient's age whenever feasible.
Marginal adaptation analysis of CAD/CAM resin crown with non-invasive methods
Authors: Zeng Chen , Tabata Tomoko , Takahashi Rena , Ikeda Masaomi , Shinagawa Junichi , Nakagawa Hisaichi , Tsuchida Yumi , Takano Shunsuke , Sumi Yasunori , Shimada Yasushi 
Published: November 2024

Abstract

Objectives: This study compared the silicone replica method with swept-source optical coherence tomography (SS-OCT) to analyze marginal adaptation and investigated the effect of the light incidence angle of SS-OCT on measurement precision.
Materials and Methods: A typodont-prepared mandibular right first molar was scanned using an intraoral scanner (Trios 3). Fourteen crowns were fabricated from CAD/CAM resin blocks (Katana Avencia P) using a 5-axis milling machine (DWX-52D). Marginal adaptation at the buccal, lingual, mesial, and distal points was assessed using the silicone replica method and SS-OCT at light incidence angles of 60°, 75°, and 90°. Statistical comparisons were performed using two-way analysis of variance (ANOVA) and t-tests with Bonferroni correction, and t-tests at a significance level of 0.05.
Results: At 60°, SS-OCT showed significantly larger marginal discrepancies than the silicone replica method at the buccal, lingual, and mesial points (p<0.05). At 75°, only the lingual point showed a significantly larger value than the silicone replica method (p<0.05). At 90°, no significant differences were observed between the SS-OCT and silicone replica methods (p>0.05). Marginal discrepancy values increased as the angle changed from 90° to 75° to 60°, with significant differences between 60° and 75° and between 60° and 90° at the buccal and lingual points (p<0.05).
Conclusions: SS-OCT is a viable alternative to the silicone replica method for assessing marginal adaptation at an incidence angle of 90 °.
Clinical Relevance: SS-OCT, a non-invasive method, has the potential to be applied clinically for evaluating marginal fit in indirect restorations in vivo.
A Novel Sweat Sensor Detects Specific Inflammatory Circadian Patterns in Inpatients and Outpatients with Cirrhosis
Authors: Davis Brian C. , Lin Kai-Chun , Shahub Sarah , Ramasubramanya Annapoorna , Fagan Andrew , Muthukumar Sriram , Prasad Shalini , Bajaj Jasmohan S. 
Published: November 2024

Abstract

Cirrhosis is the end stage result of chronic liver injury and clinical events are driven by worsening of complex inflammatory pathways leading to frequent hospitalizations and death or need for liver transplantation. Inflammatory biomarkers such as c-reactive protein (CRP), tumor necrosis factor alpha (TNFα) and interleukin-6 (IL6) are typically elevated in serum of cirrhosis patients and associated with worse outcomes. These markers are not routinely checked due to the invasive nature of blood draws and difficulty in interpretation of a single measurement. Therefore, we designed a study to measure these biomarkers using a continuous monitor of passively expressed sweat in a well characterized cohort of subjects with cirrhosis. We enrolled 32 patients with cirrhosis and 12 controls. The AWARE sweat sensor was placed on each subject with the sensor staying in continuous contact with the skin and exchanged daily for 3 days. Serum lab draws to measure CRP, TNFα, IL6, and liver function were performed along with quality-of-life surveys and hepatic encephalopathy testing. We found that CRP, TNFα, and IL6 were correlated in sweat and serum among cirrhosis and controls. All three biomarkers in sweat and serum were elevated in inpatients compared with outpatients or controls. IL6, whether measured in sweat or serum, was associated with lower transplant-free survival. Continuous monitoring of sweat showed nocturnal elevations of CRP and IL6 when compared to healthy controls. Outpatients with cirrhosis were consistently found to have inflammation levels starting to elevate during the evening periods and peaking towards the early night periods. The levels start to fall much later in the night periods and early morning periods. These data suggest that further investigation of continuous measurement of sweat biomarkers in patients with cirrhosis is warranted.