bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrological response to climate and land use and land cover change in the Teesta River basin
Authors: Rahman Syadur , Islam A. K. M. Saiful 
Published: November 2024

ABSTRACT
The Teesta basin is shared by Bangladesh and India, holds significant importance in the bilateral relationship, and sustains the livelihoods of over 30 million people in Bangladesh. Employing a cellular-automata model (CA), we accurately estimate LULC for the 2020s and projected for the 2050s and 2080s. A semi-distributed hydrological model, Soil Water Assessment Tool (SWAT), is used to generate flow for the base period (1995–2014), the near future (2035–2064), and the far future (2071–2100). SWAT model is forced by eight general circulation models (GCMs) under two socioeconomic pathways (SSP245 and SSP585). The CA-Markov prediction indicates LULC changes, especially increased agriculture and settlements by 76 and 42%, and decreased forest and water by 13 and 36%, respectively, which are expected by 2050s and will influence discharge patterns. This results in additional discharge increases of 4% (–8 to 5%) for SSP245 and 5% (–8 to 10%) for SSP585 scenarios during wet seasons. In the far future, monsoon flow will increase by 13% (0.4 to 23%) for SSP245 and 52% (–29 to 151%) under SSP245 and SSP585. A marginal change in winter flow was shown by –6% (–16 to 4%) reduction under SSP245 and –13% (–64 to 63%) under SSP585 reduction in the 2080s.
Safe drinking water: to what extent are shallow wells reliable?
Authors: Breternitz Bruna Suellen , Dropa Milena , Martone-Rocha Solange , Ferraro Pedro Smith Pereira , dos Santos Peternella Francisca Alzira , Lopes da Silva Miriam , Razzolini Maria Tereza Pepe 
Published: November 2024

ABSTRACT
Our study investigated the presence of Cryptosporidium hominis-parvum-meleagridis and Giardia duodenalis in shallow wells used for drinking water (DW) in a rural area. Also, bovine feces were collected from their vicinity. Our findings highlight significant potential risks associated with these pathogens in DW sources. Due to the COVID-19 pandemic, samples were collected in two phases: September/2019 to March/2020 and October/2021 to April/2022. Water samples (n = 69) and feces (n = 13) were collected biweekly and analyzed using the USEPA 1623.1 method and molecular tools for species identification, and feces by direct DNA extraction. During the first phase, oocysts and cysts were detected at frequencies ranging from 9.1 to 41.7 and 27.3 to 83.3, respectively. In the second phase, oocyst frequencies ranged from not detected to 25%, while cyst ranged from 18.2 to 83.3%. Escherichia coli concentrations were significant at all collection points. C. hominis-parvum-meleagridis and G. duodenalis were notably detected in bovine feces. Our study revealed the presence of anthropogenic parasites and E. coli in DW sources intended for human consumption. These findings underscore the urgent need for preventive measures to ensure safe DW and prevent future contamination. Effective water quality surveillance is crucial in this regard.
Investigating the Factors Affecting Sexual Myths in Women and Men Based on the Biopsychosocial Model: A Scoping Review
Authors: Roushan Faezeh Habibnejad , Azizi Marzieh , Habibi Farangis , Khani Soghra 
Published: November 2024

Background:
Sexual myths are mainly devoid of any substantial evidence and are passed
on by word of mouth. Myths about sexuality may thus diminish the quality of sexual activities,
cause sexual dysfunctions, including erectile dysfunction (impotence), vaginismus, difficulty reaching
an orgasm, and premature ejaculation, and make individuals feel dread, anxiety, and failure or
inadequacy, which can have adverse effects on their sexual identity.

Objective:
This study investigated the factors affecting sexual myths in women and men based on
the biopsychosocial model.

Methods:
In this scoping review, the research databases of PubMed, Google Scholar, Magiran,
PsycINFO, IranDoc, Ovid, ProQuest, Scientific Information Database (SID), and the Cochrane Library
were systematically searched. For this purpose, a systematic search was conducted to retrieve
the relevant articles from November 3 to 21, 2023, using the keywords of “sexual myth, sexual beliefs,
wrong beliefs, dysfunctional sexual beliefs, sexuality, opinions, and associated factors.” The
Newcastle-Ottawa Scale (NOS) further evaluated the quality of the included studies. The data were
then extracted from all the articles that met the eligibility criteria based on the study objectives.

Results:
In total, 12 articles were reviewed, whose data were grouped into three general categories,
viz., (i) biological factors (i.e., age and gender), (ii) psychological factors (that is, sexual dysfunction,
political opinions, opinions on virginity), and (iii) social factors (namely, educational attainment,
occupation, place of residence, marital status, type of marriage, age at marriage, premarital
sexual experience, parents’ educational attainment, spouse’s educational attainment, number of
children, parent’s employment status, spouse’s occupation, primary source of information about sex
and feelings about sexual conversations, information about sexual life, academic department, sexual
health assessment, and religious beliefs).

Conclusion:
Biopsychosocial factors could significantly affect sexual myths; therefore, considering
their mediating role in providing sex education to women and men is crucial.
Foot Reflexology for Managing Menopausal Symptoms in Women: A Systematic Review and Meta-Analysis
Authors: Maghalian Mahsa , Alikamali Maryam , Aslanpur Farzaneh , Mirghafourvand Mojgan 
Published: November 2024

Background:
Menopause can cause a variety of unpleasant symptoms, such as hot flashes,
night sweats, mood swings, and sleep disturbances. Although hormone replacement therapy is
frequently utilized to help manage these issues, long-term use of this treatment approach carries certain
potential risks.

Objective:
This study aims to examine the effects of foot reflexology, a type of massage therapy
that focuses on applying pressure to specific reflex points on the feet, on menopausal symptoms
(primary outcome) and anxiety, fatigue, and depression (secondary outcomes).

Methods:
A systematic electronic search for relevant studies was conducted in PubMed, Scopus,
Web of Science, the Cochrane Library, SID, Magiran, and Google Scholar until September 21,
2023. In addition to the electronic database searches, manual searches were also performed. This
manual search process included scanning the reference lists of the included studies and handsearching
key journals in the topic area. The risk of bias was assessed via the RoB 2.0 and ROBIN-I
tools. Heterogeneity was evaluated via the I² statistic, and in cases of high heterogeneity, a random
effects model was used instead of a fixed effects model. Subgroup analyses were performed for the
primary outcome on the basis of menopausal symptoms (vasomotor/psychosocial/physical/sexual).
The certainty of evidence was assessed via the GRADE approach.

Results:
A total of 186 articles were retrieved from database searches, and an additional 9 articles
were identified through manual searches. Ultimately, 8 studies were included in the systematic review,
and 6 studies were included in the meta-analysis. The meta-analysis revealed that foot reflexology
had a significant effect on menopausal symptoms, with an average reduction of 3.41 points
on the associated measurement scale (95% confidence interval (CI): -4.81 to -2.01; low-certainty
evidence). It also significantly reduced fatigue, with an average reduction of 5.84 points (95% CI: -
11.61 to -0.06; very low-certainty evidence). However, there was no significant impact on anxiety
(SMD: -0.89, 95% CI: -1.96--0.18; very low-certainty evidence) or depression (SMD: -0.73, 95%
CI: -1.80--0.34; very low-certainty evidence) compared with the control group.

Conclusion:
The present study demonstrated that the use of foot reflexology as a nonhormonal and
noninvasive intervention led to a significant reduction in menopausal symptoms and fatigue among
women. Given the limited number of studies available in this area and the low to very low-level
certainty of the evidence for the desired outcomes, further research with appropriate methodologies
to ensure accurate conclusions in this field is strongly recommended.
Recent Updates on Chemo Biodiversity of the Genus Cladosporium
Authors: Abdelatty Nousiba Ahmad , Attia Eman Zekry , Hamed Ashraf Nageeb Elsayed , Abdelmohsen Usama Ramadan , Desoukey Samar Yehia , Fouad Mostafa Ahmed 
Published: November 2024

Abstract:
Endophytes are an appealing source of natural products with unique structures that can
aid in the treatment of life-altering disorders because of the complexity and structural variety of the
secondary metabolites they produce. The genus Cladosporium, which belongs to family Cladosporiaceae,
class Dothideomycetes has received more attention due to the isolation of various classes of
compounds with unique structures mainly alkaloids, azaphilones, benzofluoranthenones, coumarins,
isocumarins, lactones, naphthalenones, macrolides, perylenequinones and steroids that exhibited
diverse biological activities as: antiviral, antimicrobial, anti-inflammatory, antidiabetic, phytotoxicity
and anti-Alzheimer, whereas anticancer compounds predominated. This review focuses on the isolated
secondary metabolites from genus Cladosporium specifically, C. cladosporioides, C. sphaerospermum,
C. herbarum, C. halotolerans, C. tenuissimum, C. oxyspormum, C. perangustum, C. uredinicola,
C. colocasiae, C. delicatulum and C. phlei due to their exquisite bioactivity, the source of
the strains, the culture media, the biological potential of isolated secondary metabolites and covers
the literature from 2000 to 2023.
Bigels as Novel Drug Delivery Systems: A Systematic Review on Efficiency and Influential Factors
Authors: Shakouri Shahrzad , Tehrani Mostafa Mazaheri , Koocheki Arash , Farhoosh Reza , Abdolshahi Anna , Shariatifar Nabi 
Published: November 2024

Background:
Bigles are novel formulation merging two phase of hydrogel and organogel
revealing dual properties to release active agents based on their lipophilic or hydrophilic nature.

Methods:
A systematic search was conducted in PubMed, Scopus, and ISI Web of Science to find
eligible studies evaluating the efficiency of bigels in drug release. 20 articles were included in the
analysis based on the defined criteria.

Results:
The results indicated that several different natural materials were used for bigel making.
Span (52.38%) and Sunflower oil (23.80%) were the most solvents used for organogel formation.
Also, gelatin, agar, gums, and other types of biopolymer were used as hydroglators. Most research
(33.33%) focused on the release of metronidazole from bigel structure. Also, the range of drug release
rates was 1.59 - 100% and in 42.85% of studies was >90%. The nature, content, and properties
of both organogel and hydrogel and some process variables such as temperature, mixing speed
and storage conditions were highlighted as the main influential factors on bigel formation and its
bioactivity.

Conclusion:
Bigels are an innovative structure that provides desired physicochemical and rheological
properties for industrial applications. Excellent biocompatibility and in vitro / ex vivo results
have been documented for developed bigels. In this regard, an optimal preparation method is very
important to show superior therapeutic effects.
Socioeconomic factors and university student dropout
Authors: Zamora-Vélez Glicerio Alberto , Bermúdez-Cevallos Lilia del Rocío 
Published: November 2024

The investigation adopted a mixed approach (qualitative and quantitative) in order to analyze the different factors of dropout. Based on the analysis of the socioeconomic factors that constitute an element that affects student dropout at the Eloy Alfaro Lay University of Manabí ext. Chone. The methods used were: Bibliographic, analytical/synthetic, inductive/deductive, documentary, and descriptive. The documentary method contributed to collecting information from the Academic Commission and Secretariat of this institution that contributed to supporting the research. The results showed that the main causes for student dropout are lack of time, work impediments, health problems, and economic situation. In the period from 2020 to 2023, 509 students were registered, of which 446 students graduated in different careers. According to the information collected through the teacher survey, it was determined that the main reasons for student dropout are linked to the lack of economic resources, work aspects, and family problems. At the level of conclusions and based on the data obtained, it was possible to demonstrate that socioeconomic factors constitute an element that affects student dropout. Factors such as academic, economic, family, intention to drop out, motivational, health, and social factors can influence university student dropout.
PENGARUH KONSENTRASI KOMBINASI 2,4-D DAN TDZ TERHADAP PERTUMBUHAN TUNAS AKSILER ANGGREK (Dendrobium Red Emperor Prince)
Authors: Setiawan Andri Dias , Mercuriani Ixora Sartika , Sugiarto Lili , Ratnawati Ratnawati , Aloysius Suyitno 
Published: November 2024

Abstrak.Anggrek merupakan tanaman hias yang memiliki nilai ekonomi yang tinggi. Penelitian ini bertujuan untuk mengetahui pengaruh dan konsentrasi optimal zat pengatur tumbuh (ZPT) 2,4-dichlorophenoxy acid (2,4-D) dan Thidiazuron (TDZ) terhadap pertumbuhan tunas aksiler anggrek Dendrobium Red Emperor Prince. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 2 faktor perlakuan yaitu konsentrasi 2,4-D dan TDZ ((0,0), (0,4), (0,5,3), (1,2), (1,5,1) dan (2,0)) dan posisi nodus (atas, tengah dan bawah) sebanyak 6 ulangan. Data dianailisis dengan menggunakan two-way ANOVA dan uji lanjut menggunakan DMRT 5%. Hasil penelitian menunjukan bahwa konsentrasi (0 ppm,4 ppm) mampu menginduksi tunas aksiler dan (1,5 ppm dan 1 ppm) mampu menginduksi akar anggrek Dendrobium Red Emperor Prince lebih baik. Kata kunci: 2,4-D, TDZ, induksi tunas aksiler, Dendrobium Red Emperor PrinceAbstract. Orchids are ornamental plants that have high economic value. This study aims to determine the effect and optimal concentration of plant growth regulators (ZPT) 2,4-dichlorophenoxy acid (2,4-D) and Thidiazuron (TDZ) on the growth of axillary shoots of the Dendrobium Red Emperor Prince orchid. This study used a completely randomized design (CRD) with 2 treatment factors, namely concentrations of 2,4-D and TDZ ((0,0), (0,4), (0,5,3), (1,2), ( 1,5,1) and (2,0)) and node positions (top, middle and bottom) for 6 repetitions. Data were analyzed using two-way ANOVA and follow-up testing using 5% DMRT. The results showed that concentrations (0 ppm.4 ppm) were able to induce axillary shoots and (1.5 ppm and 1 ppm) were able to induce the roots of Dendrobium Red Emperor Prince orchids better.Keywords: 2,4-D, TDZ, axillary shoot induction, Dendrobium Red Emperor PrinceOrchids are ornamental plants that have high economic value. This study aims to determine the effect and optimal concentration of plant growth regulators (ZPT) 2,4-dichlorophenoxy acid (2,4-D) and Thidiazuron (TDZ) on the growth of axillary shoots of the Dendrobium Red Emperor Prince orchid. This study used a completely randomized design (CRD) with 2 treatment factors, namely concentrations of 2,4-D and TDZ ((0,0), (0,4), (0,5,3), (1,2), ( 1,5,1) and (2,0)) and node positions (top, middle and bottom) for 6 repetitions. Data were analyzed using two-way ANOVA and follow-up testing using 5% DMRT. The results showed that concentrations (0 ppm.4 ppm) were able to induce axillary shoots and (1.5 ppm and 1 ppm) were able to induce the roots of Dendrobium Red Emperor Prince orchids better.
Reciprocal Relationship Between Self-Control Belief and Gaming Disorder in Children and Adolescents: Longitudinal Survey Study
Authors: Zhu Shimin , Qi Di 
Published: November 2024

Abstract

Background
Children and adolescents are often at the crossroads of leisure gaming and excessive gaming. It is essential to identify the modifiable psychosocial factors influencing gaming disorder development. The lay theories of self-control (ie, the beliefs about whether self-control can be improved, also called self-control mindsets) may interplay with self-control and gaming disorder and serve as a promising influential factor for gaming disorder.

Objective
This study aims to answer the research questions “Does believing one’s self-control is unchangeable predict more severe gaming disorder symptoms later?” and “Does the severity of gaming disorder symptoms prospectively predict self-control mindsets?” with a 1-year, 2-wave, school-based longitudinal survey.

Methods
A total of 3264 students (338 in grades 4‐5 and 2926 in grades 7‐10) from 15 schools in Hong Kong participated in the classroom surveys. We used cross-lagged panel models to examine the direction of the longitudinal association between self-control mindsets and gaming disorder.

Results
A bidirectional relationship was found between self-control mindsets and gaming disorder symptom severity (the cross-lagged path from mindsets to gaming disorder: regression coefficients [b] with 95% CI [0.070, 0.020-0.12o, P=.006]; and from gaming disorder to mindsets: b with 95% CI [0.11, 0.060-0.160, P<.001]). Subgroup analyses of boy and girl participants revealed that more growth mindsets regarding self-control predicted less severe gaming disorder symptoms in girls (b=0.12, 95% CI 0.053-0.190, P=.001) but not in boys (b=0.025, 95% CI –0.050 to 0.100, P=.51), while more severe gaming disorder symptoms predicted a more fixed mindset of self-control in both boys (b=0.15, 95% CI 0.069-0.230, P<.001) and girls (b=0.098, 95% CI 0.031-0.170, P=.004) after 1 year.

Conclusions
Our findings demonstrated the negative impact of gaming disorder on one’s self-control malleability beliefs and implied that promoting a growth mindset regarding self-control might be a promising strategy for gaming disorder prevention and early intervention, especially for girls.
EyeGPT for Patient Inquiries and Medical Education: Development and Validation of an Ophthalmology Large Language Model
Authors: Chen Xiaolan , Zhao Ziwei , Zhang Weiyi , Xu Pusheng , Wu Yue , Xu Mingpu , Gao Le , Li Yinwen , Shang Xianwen , Shi Danli , He Mingguang 
Published: November 2024

Background
Large language models (LLMs) have the potential to enhance clinical flow and improve medical education, but they encounter challenges related to specialized knowledge in ophthalmology.

Objective
This study aims to enhance ophthalmic knowledge by refining a general LLM into an ophthalmology-specialized assistant for patient inquiries and medical education.

Methods
We transformed Llama2 into an ophthalmology-specialized LLM, termed EyeGPT, through the following 3 strategies: prompt engineering for role-playing, fine-tuning with publicly available data sets filtered for eye-specific terminology (83,919 samples), and retrieval-augmented generation leveraging a medical database and 14 ophthalmology textbooks. The efficacy of various EyeGPT variants was evaluated by 4 board-certified ophthalmologists through comprehensive use of 120 diverse category questions in both simple and complex question-answering scenarios. The performance of the best EyeGPT model was then compared with that of the unassisted human physician group and the EyeGPT+human group. We proposed 4 metrics for assessment: accuracy, understandability, trustworthiness, and empathy. The proportion of hallucinations was also reported.

Results
The best fine-tuned model significantly outperformed the original Llama2 model at providing informed advice (mean 9.30, SD 4.42 vs mean 13.79, SD 5.70; P<.001) and mitigating hallucinations (97/120, 80.8% vs 53/120, 44.2%, P<.001). Incorporating information retrieval from reliable sources, particularly ophthalmology textbooks, further improved the model's response compared with solely the best fine-tuned model (mean 13.08, SD 5.43 vs mean 15.14, SD 4.64; P=.001) and reduced hallucinations (71/120, 59.2% vs 57/120, 47.4%, P=.02). Subgroup analysis revealed that EyeGPT showed robustness across common diseases, with consistent performance across different users and domains. Among the variants, the model integrating fine-tuning and book retrieval ranked highest, closely followed by the combination of fine-tuning and the manual database, standalone fine-tuning, and pure role-playing methods. EyeGPT demonstrated competitive capabilities in understandability and empathy when compared with human ophthalmologists. With the assistance of EyeGPT, the performance of the ophthalmologist was notably enhanced.

Conclusions
We pioneered and introduced EyeGPT by refining a general domain LLM and conducted a comprehensive comparison and evaluation of different strategies to develop an ophthalmology-specific assistant. Our results highlight EyeGPT’s potential to assist ophthalmologists and patients in medical settings.
EDUCATION AND TECHNOLOGY IN GHANA: UNDERSTANDING THE CENTRALITY OF TECHNOLOGY INTEGRATION IN THE CLASSROOM AND BEYOND
Authors: Manu, PhD Jacob , PhD Robert Ampomah, , Akyina, PhD Kwadwo Oteng , PhD Samuel Antwi, 
Published: November 2024

The study aimed to conduct a systematic review of literature on the nature of technology integration in education. The researchers found five major areas in the literature that appeared to give policymakers guidance on how to incorporate technology into the teaching and learning process. These areas were understanding and using new technologies, funding of technologies in education, teacher preparedness in ICT integration, safeguarding ICT and perceived use in school as well as the impact of stakeholders in ICT integration. The study used the narrative review and documentary analysis approach in order to determine the essential factors of a successful technology integration strategy, examine the difficulties educators and learners have while utilising ICT in the classroom and offer recommendations on how to use technology to enhance learning outcomes. The study considered Technology Acceptance Model (TAM) by Davis (1989) and the Diffusion of Innovations by Rogers (2003) as the theoretical framework. The study recommends that Ghanaian educational institutions must embrace and successfully integrate technology in the classroom and in larger educational contexts, given the growing reliance of society on digital tools resources. Again, infrastructure in technology such as computers and tablets, consistent internet connectivity, and backup power sources in places with erratic electricity, need to be given a priority by the government and educational stakeholders. Other priority actions required are prioritising community technology centres, giving low-income students access to subsidised internet connection, and supplying subsidised gadgets.
Empirical Evidence of Factors to Improve Student Engagement from Experiential Learning Activities
Authors: Molendijk Lara , Taplin Ross H. , Brennan Andrew J. 
Published: November 2024

ABSTRACT
Experiential learning activities (ELAs) are student-centered activities, such as case studies, that have benefits derived by students being active. Although the literature contains advice on which characteristics enhance ELAs, empirical evidence measuring the impact of these characteristics on engagement is scarce. This paper aims to fill this gap by comparing student engagement from 34 ELAs with varying levels of six characteristics the literature claims are beneficial. Data from a student questionnaire are analyzed with regression and content analyses. The results suggest engagement is most effectively improved when ELAs are authentic and contain the right level of detail and, to a lesser extent, are personally relevant, incorporate the learning cycle, and incorporate critical thinking. Although not emphasized in the current ELA literature, the data also suggested method of facilitation affects engagement. Implications for evidence-based design of engaging ELAs and future research are discussed.