bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations Between State Policies Facilitating Telehealth and Buprenorphine Episode Initiation and Duration Early in the COVID Pandemic
Authors: Stein Bradley D. , Saloner Brendan K. , Sheng Flora , Sorbero Mark , Dick Andrew W. , Gordon Adam J. 
Published: November 2024

Abstract
Importance
State policies facilitating telehealth implemented early in COVID may support buprenorphine treatment of opioid use disorder. However, little empirical information is available about those policies’ effects.

Objective
Examine association between state policies that may facilitate telehealth use and buprenorphine treatment.

Design, Setting, Participants
Retrospective cohort study using 2019–2020 national pharmacy data on dispensed buprenorphine prescriptions.

Exposures
State policies implemented after March 3, 2020, public health emergency declaration requiring private insurers’ telehealth reimbursement to be commensurate with in-person service reimbursement, authorizing Medicaid reimbursement for audio-only telehealth, allowing physicians to provide cross-state telehealth services, and allowing psychologists to provide cross-state telehealth services.

Main Outcomes and Measures
(a) Duration of treatment episodes started between March 1 and March 13 in both 2019 and 2020, and (b) daily numbers of new buprenorphine treatment episodes from March 13 through December 31 in each year.

Key Results
We found little change in the number of new buprenorphine treatment episodes started in 2020 compared to 2019 and an increase in treatment duration of 10.3 days (95%CI 8.3 to 12.2 days) for episodes started in March 2020 before the public health emergency declaration compared to the comparable 2019 period. States implementing a telehealth parity policy in 2020 had 7.3% (95%CI − 13.3% to − 0.4%) fewer new buprenorphine treatment episodes. States joining the psychologist interstate compact in 2020 after the public health emergency declaration had treatment episodes 7.97 days longer (95%CI 0.78 to 15.16) than other states. None of the other policies examined was associated with changes in new treatment episodes or treatment duration.

Conclusions and Relevance
Policies undertaken during the pandemic we examined were associated with few significant changes in buprenorphine treatment initiation and duration. Findings suggest realizing the benefits of telehealth and other policy changes for buprenorphine may require more extensive implementation and infrastructure support.
Comprehensive genomic profiling for advanced hepatocellular carcinoma in clinical practice
Authors: Terashima Takeshi , Yamashita Tatsuya , Arai Kuniaki , Takata Noboru , Hayashi Tomoyuki , Seki Akihiro , Nakagawa Hidetoshi , Nio Kouki , Iida Noriho , Yamada Shinya , Shimakami Tetsuro , Takatori Hajime , Tsuji Kunihiro , Sunagozaka Hajime , Mizukoshi Eishiro , Honda Masao , Takeuchi Shinji , Yamashita Taro 
Published: November 2024

Abstract

Aim
Although several therapeutic agents show efficacy in advanced hepatocellular carcinoma (HCC), biomarkers such as comprehensive genomic profiling (CGP) for the selection of second-line treatments after immunotherapy have not been established. We evaluated the value of CGP for the treatment decision in patients with HCC.

Methods
We retrospectively studied 52 patients with advanced HCC who received CGP tests at three tertiary hospitals between February 2022 and November 2023. Genomic profiles were obtained using one of three CGP tests; 49 and 3 patients were evaluated using tissue-based and blood-based assay, respectively. The impact of CGP results on subsequent treatment selection in clinical practice and correlations between representative gene alterations and patient characteristics or responses to immunotherapy were evaluated.

Results
The most frequently observed variants were TERT mutations, followed by CTNNB1, TP53, ARID1A, and MYC mutations. Potentially druggable gene alterations were observed in 45 patients (87%), and 34 patients (65%) were recommended to receive treatments based on specific gene alterations by a molecular tumor board. Treatments were covered by health insurance in 13 patients (25%). Five patients (10%) received the recommended treatment by the date of data cut-off. There were no differences in the efficacy of immunotherapy with respect to mutation status in hTERT, CTNNB1, TP53, ARID1A, and MYC.

Conclusions
The results of the present study suggested that druggable gene alterations may provide useful information not only in proposing alternative treatment after standard of care but also in selecting second-line targeted treatments after immunotherapy for patients with advanced HCC.
Characteristics and in vitro properties of potential probiotic strain Fructobacillus tropaeoli KKP 3032 isolated from orange juice
Authors: Mikołajczuk-Szczyrba Anna , Wojtczak Adrian , Kieliszek Marek , Sokołowska Barbara 
Published: November 2024

Abstract

Fructobacillus, a Gram-positive, non-spore-forming, facultative anaerobic bacterium, belongs to the fructophilic lactic acid bacteria (FLAB) group. The group’s name originates from fructose, the favored carbon source for its members. Fructobacillus spp. are noteworthy for their distinctive traits, captivating the interest of scientists. However, there have been relatively few publications regarding the isolation and potential utilization of these microorganisms in the industry. In recent years, F. tropaeoli has garnered interest for its promising role in the food and pharmaceutical sectors, although the availability of isolates is rather limited. A more comprehensive understanding of Fructobacillus is imperative to evaluate their functionality in the industry, given their unique and exceptional properties. Our in vitro study on Fructobacillus tropaeoli KKP 3032 confirmed its fructophilic nature and high osmotolerance. This strain thrives in a 30% sugar concentration, shows resistance to low pH and bile salts, and exhibits robust autoaggregation. Additionally, it displays significant antimicrobial activity against foodborne pathogens. Evaluating its probiotic potential, it aligns with EFSA recommendations in antibiotic resistance, except for kanamycin, to which it is resistant. Further research is necessary, but preliminary analyses confirm the high probiotic potential of F. tropaeoli KKP 3032 and its ability to thrive in the presence of high concentrations of fructose. The results indicate that the isolate F. tropaeoli KKP 3032 could potentially be used in the future as a fructophilic probiotic, protective culture, and/or active ingredient in fructose-rich food.
Teachers’ motivation to teach Aboriginal perspectives in the curriculum: links with their Aboriginal students’ academic motivation
Authors: Martin Andrew J. , Bostwick Keiko C. P. , Durksen Tracy L. , Amazan Rose , Lowe Kevin , Weuffen Sara 
Published: November 2024

AbstractTeaching Aboriginal perspectives is a cross-curriculum priority aimed at supporting Aboriginal school students’ beliefs about themselves and promoting mutual respect and understanding between Aboriginal and non-Aboriginal members of society. Many teachers feel they lack the efficacy to teach Aboriginal perspectives, and this may have implications for their Aboriginal students’ academic development. The present study of 293 Australian school teachers investigated their motivation (self-efficacy and valuing) to teach Aboriginal perspectives, the predictive roles of intrapersonal (adaptability) and interpersonal (teacher-student relationships) agency, and links between their motivation and the academic motivation (academic self-efficacy and valuing of school) of Aboriginal students in their class. We found that adaptability and relational connections with Aboriginal students were associated with greater motivation to teach Aboriginal perspectives that in turn was positively associated with perceptions of their Aboriginal students’ academic motivation. These results provide insight into the motivational dimensions of teaching Aboriginal perspectives and the factors that may be targeted to better support this motivation, with a view to better supporting Aboriginal students’ own motivation to learn at school.
Sensors: future tools for detecting young patient’s stress during a dental invasive versus a non-invasive dental treatment—a pilot study
Authors: Jaldin C. , Jonasson C. , Fagrell T. , Robertson A. , Krekmanova L. 
Published: November 2024

Abstract

Aim
A reliable tool to visualise children’s early stress signs to prevent dental fear development is needed. The aim was to evaluate the commercially available, CE marked, Shimmer3 GSR + unit’s ability to indicate for stress as a reaction of fear or pain for a non-invasive dental treatment (NI) and an invasive dental treatment (I).

Methods
Patients 14–16 years old were invited to undergo an oral check-up (NI) or an orthodontic premolar extraction (I), respectively. Digital data, measured via electrodes and optical pulse probe, placed on the wrist and fingers, monitored by the Shimmer3 GSR + unit, was transferred via Bluetooth to the HP-laptop. The observed digital parameters were: heart rate based on photoplethysmography (PPG), galvanic skin response (GSR), and 3-axis gyroscope and accelerometer signals for hand movements. Protocols for patient self-report scales were used: coloured analogue scale for pain intensity, facial analogue scale for the mood, and a dental fear scale. Descriptive statistics was performed.

Results
The NI-group: 20 patients, (14.6 ± 0.5 years), underwent 20 oral check-ups. The I-group: 14 patients, (15.3 ± 0.5 years), underwent 28 premolar extractions. All patients tolerated the Shimmer3 GSR + unit well. The GSR signal increased significantly, at start and during the oral injection, in the I-group. The GSR amplitudes persisted throughout and post the dental injection. No general uniform pattern or high GSR amplitudes were produced regarding NI-group.

Conclusions
Considering the limitations of this study, the following conclusions can be made: the invasive treatment resulted in a specific unison GSR pattern, while the non-invasive procedure showed individually scattered GSR reactions. The commercially available CE-marked Shimmer3 GSR + device indicated the patient's stress response triggered by the invasive anaesthetic procedure.
Dysmagnesemia with acute kidney injury among older adults: clinical characteristics and prognostic importance
Authors: Li Qinglin , Hu Xin , Li Guanggang , Li Dawei , Ao Qiangguo , Zhou Feihu 
Published: November 2024

Abstract
Purpose
The relationship between dysmagnesemia and all-cause mortality probability in individuals with acute kidney injury (AKI) have not been investigated. In this study, we evaluated the correlation of varying magnesium levels with mortality in older adults undergoing AKI.

Patients and methods
Older adults receiving treatment at the Chinese PLA General Hospital between 2007 and 2018 were retrospectively recruited. All-cause mortality was evaluated at four preset magnesium concentrations: <0.8, 0.8–0.9, 0.9–1.0, and ≥ 1.0 mmol/L. Using multivariable-adjusted Cox assessment, the all-cause mortality risk was approximated by setting the reference magnesium concentration at 0.8–0.9 mmol/L.

Results
Totally 744 participants were enrolled, whose median age was 88 years, with most of them being male (94.2%). Among them, 184 patients were assigned into the < 0.8 mmol/L group, 156 into the 0.8–0.9 mmol/L group, 206 into the 0.9–1.0 mmol/L group, and 198 into the ≥ 1.0 mmol/L group. After 28 days, the mortality rates in the four strata were 26.6, 17.9, 17.5, and 37.4%, respectively. The corresponding mortalities after 90 days were 42.4, 23.7, 26.7, and 45.5%, respectively. Compared with patients who had magnesium levels of 0.8–0.9 mmol/L, those with magnesium levels < 0.8 mmol/L (P = 0.048), and ≥ 1.0 mmol/L (P < 0.001) exhibited higher 28-day mortalities. Significant correlations also showed that patients with magnesium levels < 0.8 mmol/L (P = 0.017) and ≥ 1.0 mmol/L (P < 0.001) were significantly related to the increased 90-day mortality.

Conclusion
Magnesium levels outside the interval of 0.8–1.0 mmol/L were related to the higher risks of 28- and 90-day mortalities among older adults with AKI.
Assessing the Effect of Field Disturbances On Biomass Estimation in Grasslands Using UAV-Derived Canopy Height Models
Authors: Bazzo Clara Oliva Gonçalves , Kamali Bahareh , Behrend Dominik , Hueging Hubert , Schleip Inga , Mosebach Paul , Behrendt Axel , Gaiser Thomas 
Published: November 2024

Abstract
Accurate estimation of biomass in grasslands is essential for understanding ecosystem health and productivity. Unmanned Aerial Vehicles (UAVs) have emerged as valuable tools for biomass estimation using canopy height models derived from high-resolution imagery. However, the impact of field disturbances, such as lodging and molehills, on the accuracy of biomass estimation using UAV-derived canopy height models remains underexplored. This study aimed to assess the relationship between UAV-derived canopy height and both reference canopy height measurements and dry biomass, accounting for different management systems and disturbance scenarios. UAV data were collected using a multispectral camera, and ground-based measurements were obtained for validation. The results revealed that UAV-derived canopy height models remained accurate in estimating vegetation height, even in the presence of disturbances. However, the relationship between UAV-derived canopy height and dry biomass was affected by disturbances, leading to overestimation or underestimation of biomass depending on disturbance type and severity. The impact of disturbances on biomass estimation varied across cutting systems. These findings highlight the potential of UAV-derived canopy height models for estimating vegetation structure, but also underscore the need for caution in relying solely on these models for accurate biomass estimation in heterogeneous grasslands. Future research should explore strategies to enhance biomass estimation accuracy by integrating additional data sources and accounting for field disturbances.
The Impact of Transferring Embodiment and Work Efficiency Between Natural Body and Modular Body Systems
Authors: Vimolmongkolporn Vitvasin , Iwasaki Yukiko , Kato Fumihiro , Iwata Hiroyasu 
Published: November 2024

AbstractHuman augmentation technology, particularly supernumerary robotic limbs, has seen rapid growth and offers promising applications. However, the cognitive aspects of supernumerary robotic limbs, such as the sense of embodiment, remain underexplored in the context of modular body systems that which provide the part of one’s own body feeling, especially when detached, and how this might impact work efficiency. This study aims to investigate the impact of experience of synchronizing Sense of Embodiment and work efficiency between the user’s innate body and a modular body system. The experiment was conducted using a modular body prototype and compared between with wearing experience (the user is more likely to perceive this robot as a part of their body) and without wearing experience (the user is more likely to perceive this robot as a separate, standalone robot). Objective evaluations included task completion time and accuracy, while the sense of embodiment questionnaire was employed for subjective evaluations. The results suggested that after having experience of wearing modular arm for a while, this experience can influence the work efficiency even if it was used without wearing it.
Fuzzy logic as a method of analysis of hot forging process of 80MnSi8-6 steel
Authors: Wojtaszek Marek , Korpała Grzegorz , Zyguła Krystian , Cichocki Kamil , Kowalczyk Karolina , Skonieczna Wiktoria , Mrzygłód Barbara , Prahl Ulrich , Jabłońska Magdalena Barbara 
Published: November 2024

Abstract
A novel approach was proposed, based on the application of the fuzzy logic (FL) method for the fast analysis of the hot deformation process of 80MnSi8-6 steel. In the first stage, the curves developed from plastometric tests and the results of studies of the microstructure of the deformed samples were used as input data for the analysis. Input and output variables were adopted and a set of rules based on cause-and-effect relationships was defined, defining the interactions between the variables. A fast FL-controller was designed, and the correctness of its operation was verified by comparison with experimental results and the results of finite element method (FEM) analysis, carried out taking into account the evolution of the microstructure. The process of hot compression under isothermal conditions of 80MnSi8-6 steel specimens was simulated on the Warmumformsimulator (WUMSI), assuming such parameters and other conditions as were used in real tests. It was confirmed that the proposed method, based on the analysis of flow curves and prior austenite grain size using a fuzzy controller, gave satisfactory results. Subsequently, a novel FL-controller was developed to analyze the kinetics of dynamic recrystallization (DRX), using data obtained from the author’s model of this phenomenon for its construction and calibration. The correctness of the controller was confirmed by comparing the results of its DRX volume fraction calculations with the distributions of this value determined by the model and the model-based FEM analysis method, respectively. It was shown that FL is applicable also when a model of the analyzed phenomenon is available. Unlike model-based calculations, a properly designed controller allows the indication of deviations from general trends that can be pointed out and interpreted by a human expert, but significantly faster. It can also serve as a component of a system analyzing complex processes, such as hot multi-stage forging. Fuzzy controller can be used in parallel with modeling or replace models in calculations.
Digital Sovereignty: A Descriptive Analysis and a Critical Evaluation of Existing Models
Authors: Fratini Samuele , Hine Emmie , Novelli Claudio , Roberts Huw , Floridi Luciano 
Published: November 2024

Abstract
Digital sovereignty is a popular yet still emerging concept. It is claimed by and related to various global actors, whose narratives are often competing and mutually inconsistent. This article offers a mapping of the types of national digital sovereignty that are emerging, while testing their effectiveness in response to radical changes and challenges. To do this, we systematically analyse a corpus of 271 peer-reviewed articles to identify descriptive features (how digital sovereignty is pursued) and value features (why digital sovereignty is pursued), which we use to produce four models: the rights-based model, market-oriented model, centralisation model, and state-based model. We evaluate their effectiveness within a framework of robust governance that accounts for the models’ ability to absorb the disruptions caused by technological advancements, geopolitical changes, and evolving societal norms. We find that none of the models fully combine comprehensive regulation of digital technologies with a sufficient degree of responsiveness to fast-paced technological innovation and social and economic shifts. This paper’s analysis offers valuable lessons to policymakers who wish to implement an effective and robust form of digital sovereignty.
Altermagnetic topological insulator with $\mathcal{C}$-paired spin-valley locking
Authors: Ma Hai-Yang , Jia Jin-Feng 
Published: November 2024

AbstractAltermagnetism emerges as the third fundamental collinear magnetism recently. Associating nontrivial topology and quantum orders to this newly established magnetism is an important physical topic and may lead to interesting physics such as unusual quantum spin Hall effect with time-reversal-symmetry breaking, topological superconductivity and spin-valley locking. Here, we first generalize the spinless Haldane model from the usual honeycomb lattice to the otherwise simpler square lattice. We then restore the doublet spin degree of freedom, the resulted spinful model resembles the Kane-Mele model and is able to describe the unprecedented physics which intertwine $\mathcal{C}$
C
-paired spin-valley locking, Dirac physics, nontrivial band topology and altermagnetism. Our works shed lights on future studies and applications in spintronics and valleytronics for altermagnetic materials, the lattice theories developed in this article may also find their broad applications to optical lattice with ultra cold atoms, photonic lattice, etc. other than the usual electronic systems.
Utilizing virtual communities of practice in the national campaign of wheat in Egypt: action research
Authors: Kassem Mohamed , Habaa Laila , Aly Fekry , Shabana Rasha , Farag Mohamed , Imaraa Naglaa , Atwa Atwa 
Published: November 2024

Abstract
Background
Virtual Community of Practices (VCoP) simply is a method to use social media in extension, yet its roots depend on a combination of four concepts: community of practice, social media, social learning theory, and pluralistic extension. The technical action research design was followed to put the VCoP into action and explore its profile. This study aimed to introduce a community of practice using social network applications to policy makers in the agricultural sector.

Methodology
Action research was conducted to validate the use of a VCoP in the National Campaign of Wheat in Egypt. A baseline survey, a content analysis of VCoP conversations, and an assessment study were used to collect the data. The frequency, range, percentage, mean, and average score were used for statistical analysis.

Results
The VCoP reached 22.22% and 10.40% of the wheat farmers in the two target villages, respectively. A high degree of knowledge exchange was detected among members, while messages crossed the VCoP borders as friends were invited to join the group. The VCoP helped its members establish new relationships with other stakeholders, and they expressed their need to expand membership to include other stakeholders. The media used in the VCoP was satisfactory; however, the need for more video messages and internet links was expressed. Extension agents believe that the VCoP complements other extension methods. Farmers see greater potential for cooperation than conflict, while bias is minimal among research, extension, traders, and company agents.

Conclusions
Farmers and other service providers in a village can be aggregated in a VCoP. This approach has proven to be valid as an extension community method for generating and sharing information with high “reach”. Coordination and training are essential for running and managing groups. Yearly programs, rather than seasonal programs, are more suitable for sustainability.