bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictability of a modified Mini- Nutritional- Assessment version on six-month and one-year mortality in hospitalized geriatric patients: a comparative analysis
Authors: Becker Lea , Volkert Dorothee , Christian Sieber Cornel , Gaßmann Karl-Günter , Ritt Martin 
Published: June 2019

AbstractRecently we introduced a modified Mini Nutritional Assessment (MNA) Short Form (MNA-SF) and Long Form (MNA-SF) with operationalization of the ‘mobility’ and ‘neuropsychological problems’ items of the MNA using scores on Barthel Index mobility item and Mini Mental State Examination and Geriatric Depression Scale scores. We have now evaluated the abilities of this modified MNA-SF and MNA-LF to predict mortality in comparison with the standard MNA-SF and MNA-LF and the Nutritional Risk Screening 2002 (NRS 2002) and the Malnutrition Universal Screening Tool (MUST). A prospective analysis was performed in 240 hospitalised geriatric patients aged ≥ 65 years. Malnutrition and/or malnutrition risk were assessed using the modified MNA-SF and MNA-LF, the standard MNA-SF and MNA-LF, and the NRS 2002 and MUST. The modified MNA-SF and MNA-LF and the standard MNA-SF and MNA-LF assessments (all p < 0.05), but not NRS 2002 or MUST (all p ≥ 0.05), predicted six-month and/or one-year mortality. Prediction of six-month and/or one-year mortality by the modified MNA-SF was comparable with predictions by the standard MNA-SF and MNA-LF (all p ≥ 0.05). The modified MNA-LF showed better prediction of six-month and one-year mortality than the standard MNA-SF and MNA-LF (all p < 0.05). The modified MNA-LF (all adjusted p < 0.05), but none of the other instruments (all adjusted p ≥ 0.05), predicted six-month and one-year mortality independently of age, sex, frailty, comorbidity and ADL disability burden. The modified MNA-SF and MNA-LF emerged as potentially valuable tools for predicting mortality in patients hospitalised on geriatric wards.
Lupin (Lupinus spp.) seeds exert anthelmintic activity associated with their alkaloid content
Authors: Dubois O. , Allanic C. , Charvet C. L. , Guégnard F. , Février H. , Théry-Koné I. , Cortet J. , Koch C. , Bouvier F. , Fassier T. , Marcon D. , Magnin-Robert J. B. , Peineau N. , Courtot E. , Huau C. , Meynadier A. , Enguehard-Gueiffier C. , Neveu C. , Boudesocque-Delaye L. , Sallé G. 
Published: June 2019

AbstractThe growing range of drug resistant parasitic nematode populations threatens the sustainability of ruminant farming worldwide. In this context, nutraceuticals, animal feed that provides necessary dietary requirements while ensuring parasite control, could contribute to increase farming sustainability in developed and low resource settings. In this study, we evaluated the anthelmintic potential of lupin seed extracts against the major ruminant trichostrongylids, Haemonchus contortus and Teladorsagia circumcincta. In vitro observations showed that seed extracts from commercially available lupin varieties could significantly but moderately inhibit larval migration. This anthelmintic effect was mediated by the seed alkaloid content and was potent against both fully susceptible and multidrug resistant H. contortus isolates as well as a susceptible T. circumcincta isolate. Analytical chemistry revealed a set of four lupanine and sparteine-derivatives with anthelmintic activity, and electrophysiology assays on recombinant nematode acetylcholine receptors suggested an antagonistic mode of action for lupin alkaloids. An in vivo trial in H. contortus infected lupin-fed ewes and goats failed to demonstrate any direct anthelmintic effect of crude lupin seeds but infected lupin-fed goats suffered significantly less parasite-mediated blood losses. Altogether, our findings suggest that the anthelmintic potential of lupin remains limited. However, the potent alkaloids identified could lead to the development of novel drugs or may be used in combination with current anthelmintics to improve their efficacy.
Colour change and behavioural choice facilitate chameleon prawn camouflage against different seaweed backgrounds
Authors: Green Samuel D. , Duarte Rafael C. , Kellett Emily , Alagaratnam Natasha , Stevens Martin 
Published: June 2019

AbstractCamouflage is driven by matching the visual environment, yet natural habitats are rarely uniform and comprise many backgrounds. Therefore, species often exhibit adaptive traits to maintain crypsis, including colour change and behavioural choice of substrates. However, previous work largely considered these solutions in isolation, whereas many species may use a combination of behaviour and appearance to facilitate concealment. Here we show that green and red chameleon prawns (Hippolyte varians) closely resemble their associated seaweed substrates to the vision of predatory fish, and that they can change colour to effectively match new backgrounds. Prawns also select colour-matching substrates when offered a choice. However, colour change occurs over weeks, consistent with seasonal changes in algal cover, whereas behavioural choice of matching substrates occurs in the short-term, facilitating matches within heterogeneous environments. We demonstrate how colour change and behaviour combine to facilitate camouflage against different substrates in environments varying spatially and temporally.
Synergies between mycorrhizal fungi and soil microbial communities increase plant nitrogen acquisition
Authors: Hestrin Rachel , Hammer Edith C. , Mueller Carsten W. , Lehmann Johannes 
Published: June 2019

AbstractNitrogen availability often restricts primary productivity in terrestrial ecosystems. Arbuscular mycorrhizal fungi are ubiquitous symbionts of terrestrial plants and can improve plant nitrogen acquisition, but have a limited ability to access organic nitrogen. Although other soil biota mineralize organic nitrogen into bioavailable forms, they may simultaneously compete for nitrogen, with unknown consequences for plant nutrition. Here, we show that synergies between the mycorrhizal fungus Rhizophagus irregularis and soil microbial communities have a highly non-additive effect on nitrogen acquisition by the model grass Brachypodium distachyon. These multipartite microbial synergies result in a doubling of the nitrogen that mycorrhizal plants acquire from organic matter and a tenfold increase in nitrogen acquisition compared to non-mycorrhizal plants grown in the absence of soil microbial communities. This previously unquantified multipartite relationship may contribute to more than 70 Tg of annually assimilated plant nitrogen, thereby playing a critical role in global nutrient cycling and ecosystem function.
Crystal structure of human endothelin ETB receptor in complex with peptide inverse agonist IRL2500
Authors: Nagiri Chisae , Shihoya Wataru , Inoue Asuka , Kadji Francois Marie Ngako , Aoki Junken , Nureki Osamu 
Published: June 2019

AbstractEndothelin receptors (ETA and ETB) are G-protein-coupled receptors activated by endothelin-1 and are involved in blood pressure regulation. IRL2500 is a peptide-mimetic of the C-terminal tripeptide of endothelin-1, and has been characterized as a potent ETB-selective antagonist, which has preventive effects against brain edema. Here, we report the crystal structure of the human ETB receptor in complex with IRL2500 at 2.7 Å-resolution. The structure revealed the different binding modes between IRL2500 and endothelin-1, and provides structural insights into its ETB-selectivity. Notably, the biphenyl group of IRL2500 penetrates into the transmembrane core proximal to D2.50, thus stabilizing the inactive conformation. Using the newly-established constitutively active mutant, we clearly demonstrate that IRL2500 functions as an inverse agonist for the ETB receptor. The current findings will expand the chemical space of ETR antagonists and facilitate the design of inverse agonists for other class A GPCRs.
Fingerprints of an orbital-selective Mott phase in the block magnetic state of BaFe2Se3 ladders
Authors: Patel N. D. , Nocera A. , Alvarez G. , Moreo A. , Johnston S. , Dagotto E. 
Published: June 2019

AbstractResonant Inelastic X-Ray Scattering (RIXS) experiments on the iron-based ladder BaFe2Se3 unveiled an unexpected two-peak structure associated with local orbital (dd) excitations in a block-type antiferromagnetic phase. A mixed character between correlated band-like and localized excitations was also reported. Here, we use the density matrix renormalization group method to calculate the momentum-resolved charge- and orbital-dynamical response functions of a multi-orbital Hubbard chain. Remarkably, our results qualitatively resemble the BaFe2Se3 RIXS data, while also capturing the presence of long-range magnetic order as found in neutron scattering, only when the model is in an exotic orbital-selective Mott phase (OSMP). In the calculations, the experimentally observed zero-momentum transfer RIXS peaks correspond to excitations between itinerant and Mott insulating orbitals. We provide experimentally testable predictions for the momentum-resolved charge and orbital dynamical structures, which can provide further insight into the OSMP regime of BaFe2Se3.
Operation of graphene magnetic field sensors near the charge neutrality point
Authors: Song Guibin , Ranjbar Mojtaba , Kiehl Richard A. 
Published: June 2019

AbstractGraphene is a promising material for sensing magnetic fields via the Hall effect due to its atomic-scale thickness, ultra-high carrier mobilities and low cost compared to conventional semiconductor sensors. Because of its Dirac band structure, graphene sensors differ from semiconductor sensors in that both electrons and holes participate in the carrier transport. This two-channel transport complicates the sensor operation and causes performance trade-offs that demand careful examination. Here, we examine the operation of graphene sensors operated near the charge neutrality point (CNP) where two-channel transport prevails. We find that, while the largest magnetoresistance occurs exactly at the CNP, the maximum realizable Hall sensitivities occur away from the CNP and depend on linearity constraints and power limitations. In particular, a more stringent linearity constraint reduces the realizable sensitivities for mobilities above a critical value µc, which scales with magnetic field.
Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC
Authors: Fast Olivia G. , Gentry Brittany , Strouth Liah , Niece Madison B. , Beckford Floyd A. , Shell Steven M. 
Published: June 2019

Abstract
Ruthenium organometallic compounds represent an attractive avenue in developing alternatives to platinum-based chemotherapeutic agents. While evidence has been presented indicating ruthenium-based compounds interact with isolated DNA in vitro, it is unclear what effect these compounds exert in cells. Moreover, the antibiotic efficacy of polynuclear ruthenium organometallic compounds remains uncertain. In the present study, we report that exposure to polynuclear ruthenium organometallic compounds induces recruitment of damaged DNA sensing protein Xeroderma pigmentosum Group C into chromatin-immobilized foci. Additionally, we observed one of the tested polynuclear ruthenium organometallic compounds displayed increased cytotoxicity against human cells deficient in nucleotide excision repair (NER). Taken together, these results suggest that polynuclear ruthenium organometallic compounds induce DNA damage in cells, and that cellular resistance to these compounds may be influenced by the NER DNA repair phenotype of the cells.
Prognostic significance of LncRNA GHET1 expression in various cancers: a systematic review and meta-analysis
Authors: Ye Jing , Sun Haiyan , Feng Zhengquan , Zhang Qiqin , Xia Yongliang , Ji Yunxi , Zhang Qiqing 
Published: June 2019

Abstract
Background: Dysregulated expression of long non-coding RNA gastric carcinoma high expressed transcript 1 (lncRNA GHET1) has been observed in several cancers, however, definite conclusion on the prognostic value of lncRNA GHET1 expression in human cancers has not been determined. The aim of this meta-analysis was to evaluate the prognostic significance of lncRNA GHET1 expression in cancers. Methods: PubMed, Web of Science and Embase were comprehensively searched for relevant studies. Meta-analyses of overall survival (OS) and clinicopathological features were conducted. Results: Ten studies were finally analyzed in the present study. High lncRNA GHET1 expression was associated with shorter OS than low lncRNA GHET1 expression in cancers (hazard ratio (HR) = 2.59, 95% CI = 1.93–3.47, P&lt;0.01). Online cross-validation using The Cancer Genome Atlas (TCGA) data observed similar results (HR = 1.10, P&lt;0.05). When compared with low lncRNA GHET1 expression, high lncRNA GHET1 expression was related to larger tumor size (P&lt;0.01), worse differentiation (P&lt;0.01), earlier distant metastasis (P=0.02), earlier lymph node metastasis (P&lt;0.01) and more advanced clinical stage (P&lt;0.01). Conclusion: High lncRNA GHET1 expression is associated with worse cancer prognosis and can serve as a promising prognostic factor of human cancers.
Long noncoding RNA MALAT1 promotes cardiomyocyte apoptosis after myocardial infarction via targeting miR-144-3p
Authors: Gong Xiaohong , Zhu Yun , Chang Haixia , Li Yongqin , Ma Feng 
Published: June 2019

Abstract
Our study aims to excavate the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in myocardial infarction (MI), especially in an ischemia/reperfusion injury model and the underlying mechanism involving the MALAT1-miR144 axis. Our results demonstrated that the expression of MALAT1 has a higher level, while miR-144 expression significantly reduced in myocardial tissue after MI and also in left anterior descending (LAD)-ligation mice. This result was confirmed in vitro studies in HL-1 cardiomyocytes followed with hypoxia/reoxygenation. In addition, overexpression of MALAT1 by MALAT1-pcDNA injection into the mice with LAD increased myocardial apoptosis in vivo, while this effect was attenuated by miR-144 mimic. Bioinformatics analysis exhibits that 3′-UTR of MALAT1 is targeted to the miR-144-3p. Up-regulation miR-144 blunted the hypoxia- or MALAT1-induced cell apoptosis. In conclusion, the expression of MALAT1 was increased, whereas miR-144 expression was down-regulated in the myocardium after AMI. MALAT1 up-regulation plays a critical role in promoting cardiomyocytes apoptosis via targeting miR-144.
Chemical (in)homogeneity and atomic diffusion in the open cluster M 67
Authors: Liu F. , Asplund M. , Yong D. , Feltzing S. , Dotter A. , Meléndez J. , Ramírez I. 
Published: June 2019

Context. The benchmark open cluster M 67 is known to have solar metallicity and an age similar to that of the Sun. It thus provides us with a great opportunity to study the properties of solar twins, as well as the evolution of Sun-like stars.
Aims. Previous spectroscopic studies of M 67 reported possible subtle changes in stellar surface abundances throughout the stellar evolutionary phase, namely the effect of atomic diffusion. In this study we attempt to confirm and quantify more precisely the effect of atomic diffusion, and to explore the level of chemical (in)homogeneity in M 67.
Methods. We presented a strictly line-by-line differential chemical abundance analysis of two groups of stars in M 67: three turn-off stars and three subgiants. Stellar atmospheric parameters and elemental abundances were obtained with very high precision using the Keck/HIRES spectra.
Results. The subgiants in our sample show negligible abundance variations (≤0.02 dex), which implies that M 67 was born chemically homogeneous. We note that there is a significant abundance difference (~0.1–0.2 dex) between subgiants and turn-off stars, which can be interpreted as the signature of atomic diffusion. Qualitatively stellar models with diffusion agree with the observed abundance results. Some turn-off stars do not follow the general pattern, which suggests that in some cases diffusion can be inhibited, or they might have undergone some sort of mixing event related to planets.
Conclusions. Our results pose additional challenges for chemical tagging when using turn-off stars. In particular, the effects of atomic diffusion, which could be as large as 0.1–0.2 dex, must be taken into account in order for chemical tagging to be successfully applied.
Gravitoviscous protoplanetary disks with a dust component
Authors: Vorobyov Eduard I. , Skliarevskii Aleksandr M. , Elbakyan Vardan G. , Pavlyuchenkov Yaroslav , Akimkin Vitaly , Guedel Manuel 
Published: June 2019

Aims. The central region of a circumstellar disk is difficult to resolve in global numerical simulations of collapsing cloud cores, but its effect on the evolution of the entire disk can be significant.
Methods. We used numerical hydrodynamics simulations to model the long-term evolution of self-gravitating and viscous circumstellar disks in the thin-disk limit. Simulations start from the gravitational collapse of pre-stellar cores of 0.5–1.0 M⊙ and both gaseous and dusty subsystems were considered, including a model for dust growth. The inner unresolved 1.0 au of the disk is replaced with a central smart cell (CSC), a simplified model that simulates physical processes that may occur in this region.
Results. We found that the mass transport rate through the CSC has an appreciable effect on the evolution of the entire disk. Models with slow mass transport form more massive and warmer disks, and are more susceptible to gravitational instability and fragmentation, including a newly identified episodic mode of disk fragmentation in the T Tauri phase of disk evolution. Models with slow mass transport through the CSC feature episodic accretion and luminosity bursts in the early evolution, while models with fast transport are characterized by a steadily declining accretion rate with low-amplitude flickering. Dust grows to a larger, decimeter size in the slow transport models and efficiently drifts in the CSC, where it accumulates and reaches the limit where a streaming instability becomes operational. We argue that gravitational instability, together with a streaming instability likely operating in the inner disk regions, constitute two concurrent planet-forming mechanisms, which may explain the observed diversity of exoplanetary orbits.
Conclusions. We conclude that sophisticated models of the inner unresolved disk regions should be used when modeling the formation and evolution of gaseous and dusty protoplanetary disks.
Zombie vortex instability in the protoplanetary disk: can we find it in the lab?
Authors: Facchini G. , Wang M. , Marcus P. , Le Bars M. 
Published: June 2019

Without instabilities, the gas in the protoplanetary disk approximately a forming protostar remains in orbit rather than falling onto the protostar and completing its formation into a star. Moreover without instabilities in the fluid flow of the gas, the dust grains within the disk’s gas cannot accumulate, agglomerate, and form planets. Keplerian disks are linearly stable by Rayleigh theorem because the angular momentum of the disk increases with increasing radius. This has led to the belief that there exists a large region in protoplanetary disks, known as the dead zone, which is stable to pure hydrodynamic disturbances. The dead zone is also believed to be stable against magneto-rotational instability (MRI) because the disks’ cool temperatures inhibit ionization and therefore prevent the MRI. A recent study Marcus et al. (2013) shows the existence of a new hydrodynamic instability called the Zombie Vortex Instability (ZVI), where successive generations of self-replicating vortices (zombie vortices) fill the disk with turbulence and destabilize it. The instability is triggered by finite-amplitude perturbations, including weak Kolmogorov noise, in stratified flows with Brunt-Väisälä frequency N, background rotation Ω and horizontal shear σ. So far there is no observational evidence of the Zombie Vortex Instability and there are very few laboratory experiments of stratified plane Couette flow with background rotation in the literature. We perform systematic simulations to determine where the Zombie Vortex Instability exists in terms of the control parameters (Reynolds number Re, σ/f and N/f). We present a parameter map showing two regimes where ZVI occurs, and interpret the physics that determines the boundaries of the two regimes. We also discuss the effects of viscosity and the existence of a threshold for Re. Our study on viscous effects, parameter map and its underlying! physics provide guidance for designing practical laboratory experiments in which ZVI could be observed.
Circulating Tumor DNA and Hepatocellular Carcinoma
Authors: Yang Ju Dong , Liu Minetta C. , Kisiel John B. 
Published: June 2019

AbstractThere is a clear and unmet need for biomarkers in hepatocellular carcinoma (HCC). Circulating cell free deoxyribonucleic acid (cfDNA) is a fragmented DNA subtype, found in the blood circulation. Circulating tumor DNA (ctDNA) is the fraction of total cfDNA, which originates from the primary tumor or metastases in patients with cancer. Earlier studies reported that quantitative measurement cfDNA has diagnostic and prognostic role for HCC. More recently, improvement in next-generation sequencing technology and better understanding of genetic or epigenetic alteration of HCC have allowed comprehensive analysis of mutational and methylation landscape of ctDNA. Hotspot mutation panels and methylation panels have both shown promising performance. None of these tests have yet been validated in longitudinal cohorts for preclinical detection of HCC. In this article, the authors discuss the currently available ctDNA detection technologies, their diagnostic and prognostic performance in HCC, and future research directions.
Revacept, a Novel Inhibitor of Platelet Adhesion, in Patients Undergoing Elective PCI—Design and Rationale of the Randomized ISAR-PLASTER Trial
Authors: Schüpke Stefanie , Hein-Rothweiler Ralph , Mayer Katharina , Janisch Marion , Sibbing Dirk , Ndrepepa Gjin , Hilz Raphaela , Laugwitz Karl-Ludwig , Bernlochner Isabell , Gschwendtner Sarah , Kupka Danny , Gori Tommaso , Zeiher Andreas M. , Schunkert Heribert , Massberg Steffen , Kastrati Adnan ,   for the ISAR-PLASTER-Trial Investigators
Published: June 2019

AbstractDespite dual antiplatelet therapy patients undergoing percutaneous coronary intervention (PCI) continue to experience periprocedural ischemic events. In addition, all currently used antithrombotic drugs increase the bleeding risk. Thus, there is an unmet clinical need for antithrombotic strategies with improved efficacy and no increase in bleeding. Revacept is a novel, lesion-directed antithrombotic drug that does not interfere with the function of circulating platelets. This dimeric fusion protein of the extracellular domain of glycoprotein VI (the major platelet collagen receptor) and the human Fc-fragment inhibits collagen-mediated platelet adhesion and subsequent aggregation at the site of vascular injury. The randomized, double-blinded, phase II ISAR-PLASTER trial is based on extensive preclinical evaluation of Revacept and a favorable first-in-man trial. A total of 332 patients with stable coronary artery disease undergoing elective PCI will be randomized to either Revacept 160 mg, Revacept 80 mg, or placebo administered as single intravenous infusion directly before the intervention, on top of standard dual antiplatelet therapy and either heparin or bivalirudin, based on local practice and current guidelines. The primary endpoint is the composite of death or myocardial injury (defined as increase in high sensitivity troponin T ≥ 5 times the upper limit of normal) at 48 hours. The safety endpoint is bleeding of class 2 or higher according to the Bleeding Academic Research Consortium at 30 days. This phase II randomized, double blind trial will assess for the first time the efficacy and safety of Revacept—a lesion-directed inhibitor of platelet adhesion—in patients undergoing elective PCI.