bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘I heard his silver Call’: Emily Dickinson and the Poetry of Telegraphic Acoustics
Authors: Tackett Justin C 
Published: February 2019

Abstract
This essay focuses on a specific aspect of electric telegraphy in America—what I call ‘telegraphic acoustics’, which includes: 1) the sound of telegraph wires vibrating overhead and 2) ‘sound-reading’, the practice of transcribing Morse code by ear instead of transcribing it from a printout. Telegraphic acoustics started as a distinctively American technical evolution that emphasized sound and listening over sight and literacy. Because of this emphasis and because of increasingly universal poetic education, American telegraphers understood their technology in poetic terms. In turn, American poets, including John Greenleaf Whittier and Oliver Wendell Holmes Sr., also thought about poetry in terms of telegraphic acoustics. The essay focuses on Emily Dickinson as an in-depth case study because of her unusual familiarity with telegraphic acoustics in Amherst; her visual impairment, which heightened her awareness of sound; and her insights into the nature and future of networks and information flow. It concludes by examining the intersection of her poetry and telephony, which was perceived as an extension of telegraphy. I argue that thinking of these media acoustically, instead of in terms of literacy, reveals a rich separate discourse running through Dickinson’s poetry and American poetry generally. This discourse demands reinterpretations of several canonical Dickinson poems.
Determinants of diagnostic delay in axial spondyloarthritis: an analysis based on linked claims and patient-reported survey data
Authors: Redeker Imke , Callhoff Johanna , Hoffmann Falk , Haibel Hildrun , Sieper Joachim , Zink Angela , Poddubnyy Denis 
Published: February 2019

AbstractObjectivesThe objective of this study was to assess the current diagnostic delay in axial SpA (axSpA) and to analyse factors associated with it.MethodsA stratified sample of subjects with a diagnosis of axSpA (International Classification of Diseases, 10th Revision code M45) was drawn from health insurance data in Germany and was questioned on disease-related, lifestyle and socio-economic characteristics. The diagnostic delay was calculated as the time from back pain onset until a diagnosis of axSpA. A multivariable linear regression analysis was performed to explore factors associated with the diagnostic delay.ResultsAmong 1677 patients with axSpA included in the analysis, the mean diagnostic delay was 5.7 years (median 2.3). Of those, 407 patients were diagnosed in 1996–2005 and 484 patients in 2006–2015. The mean diagnostic delay was not substantially different in both periods: 6.3 years (median 2.6) and 7.4 (2.7), respectively. Multivariable linear regression revealed that female sex [β = 1.85 (95% CI 1.06, 2.65)], negative HLA-B27 status [β = 3.61 (95% CI 2.07, 5.14)], presence of psoriasis [β = 1.40 (95% CI 0.08, 2.73)] and younger age at symptom onset [β = 1.91 (95% CI 1.53, 2.29)] were factors associated with a longer diagnostic delay.ConclusionThe diagnostic delay in axSpA is still unacceptably long. Patients who are female, young at symptom onset, HLA-B27 negative or have psoriasis have a longer diagnostic delay. Specific referral strategies might be necessary in order to decrease the diagnostic delay in patients presenting with these characteristics.
Differences in Health: The Influence of Gender and Institutional Settings on Sickness Claims in Gothenburg, Sweden (1898–1950)
Authors: Castenbrandt Helene , Revuelta-Eugercios Barbara Ana , Torén Kjell 
Published: February 2019

Summary
Sickness funds information has given conflicting evidence on the evolution of morbidity during the mortality decline. Evidence on increased morbidity has been explained by an actual increase of morbidity, a cultural inflation of morbidity or changing institutional settings, however, morbidity rates have also been shown to be stable over time when age composition of members is controlled for. Most previous studies have been confined to data on men; however, in an earlier article, Castenbrandt found large gender differences in historical sick leave by using national statistics on both men and women. To move forward, this article aims to analyse trends in sickness claims during the mortality decline in the early twentieth century using individual level data from Swedish sickness funds covering the period 1898–1950. Concretely, we investigate gender differences in sickness claims (incidence and duration) and how institutional settings (member composition and fund-specific regulations) affected the sick leave patterns.
New Ancorabolidae (Copepoda: Harpacticoida) from Korea: two new genera, revisionary notes and updated identification keys
Authors: Lee Jimin , Huys Rony 
Published: February 2019

AbstractTwo new copepod species of the Ceratonotus group in the subfamily Ancorabolinae (Ancorabolidae) are described from the Korean peninsula. Dendropsyllus kimi sp. nov. differs from its congeners by the one-segmented ♀ P3 endopod, the inner spine on ♀ P5 exopod and the absence of sensillate tubercles on abdominal somites 1 and 2. Dimorphipodia gen. nov. is proposed to accommodate Dimorphipodia changi sp. nov. and can be differentiated from its sister taxon, Arthuricornua, by the sexual dimorphism in P2–P4 exp-3, the absence of paired laterodorsal processes near the posterior margin of the cephalothorax and the presence of pleural setular tufts on somites bearing P2–P4. Ancorabolina, previously placed in the Ancorabolinae, is transferred to the Laophontodinae, whereas Patagoniaella is provisionally reassigned to the family Cletodidae. Within Laophontodes, the inadequately described Laophontodes brevis, Laophontodes ornatus and Laophontodes propinquus are relegated to species inquirendae. Laophontodes georgei sp. nov. is proposed for the unavailable name Laophontodes norvegicus, Laophontodes multispinatus is reassigned to Lobopleura, and Laophontodes gracilipes is fixed as the type of Rostrophontodes gen. nov., the potential sister group of Ancorabolina. The authenticity of Laophontodes bicornis and other dubious ancorabolid records from the Korean peninsula is discussed. Updated keys to genera of both Ancorabolinae and Laophontodinae and to species of Laophontodes are provided.
Early in life effects and heredity: reconciling neo-Darwinism with neo-Lamarckism under the banner of the inclusive evolutionary synthesis
Authors: Danchin Étienne , Pocheville Arnaud , Huneman Philippe 
Published: February 2019

Recent discoveries show that early in life effects often have long-lasting influences, sometimes even spanning several generations. Such intergenerational effects of early life events appear not easily reconcilable with strict genetic inheritance. However, an integrative evolutionary medicine of early life effects needs a sound view of inheritance in development and evolution. Here, we show how to articulate the gene-centred and non-gene-centred visions of inheritance. We first recall the coexistence of two gene concepts in scientific discussions, a statistical one (focused on patterns of parent–offspring resemblance, and implicitly including non-DNA-sequence-based resemblance), and a molecular one (based on the DNA sequence). We then show how all the different mechanisms of inheritance recently discovered can be integrated into an inclusive theory of evolution where different mechanisms would enable adaptation to changing environments at different timescales. One surprising consequence of this integrative vision of inheritance is that early in life effects start much earlier than fertilization.This article is part of the theme issue ‘Developing differences: early-life effects and evolutionary medicine’.
Making headway towards understanding how epigenetic mechanisms contribute to early-life effects
Authors: Vukic Maja , Wu Haoyu , Daxinger Lucia 
Published: February 2019

It has become clear that in addition to the DNA sequence there is another layer of information, termed epigenetic modifications, that can influence phenotypes and traits. In particular, environmental epigenomics, which addresses the effect of the environment on the epigenome and human health, is becoming an area of great interest for many researchers working in different scientific fields. In this review, we will consider the current evidence that early-life environmental signals can have long-term effects on the epigenome. We will further evaluate how recent technological advances may enable us to unravel the molecular mechanisms underlying these phenomena, which will be crucial for understanding heritability in health and disease.
This article is part of the theme issue ‘Developing differences: early-life effects and evolutionary medicine'.
Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR/Cas9 screening
Authors: Picco Gabriele , Chen Elisabeth D , Alonso Luz Garcia , Behan Fiona M , Gonçalves Emanuel , Bignell Graham , Matchan Angela , Fu Beiyuan , Banerjee Ruby , Anderson Elizabeth , Butler Adam , Benes Cyril H , McDermott Ultan , Dow David , Iorio Francesco , Stronach Euan , Yang Fengtang , Yusa Kosuke , Saez-Rodriguez Julio , Garnett Mathew J 
Published: February 2019

AbstractMany gene fusions have been reported in tumours and for most their role remains unknown. As fusions can be used clinically for diagnostic and prognostic purposes, and are targets for treatment, it is crucial to assess their functional implications in cancer. To investigate the role of fusions in tumor cell fitness, we developed a systematic analysis utilising RNA-sequencing data from 1,011 human cancer cell lines to functionally link 8,354 gene fusion events with genomic data, sensitivity to >350 anti-cancer drugs and CRISPR-Cas9 loss-of-fitness information. Established clinically-relevant fusions were readily identified. Overall, functional fusions were rare, including those involving cancer driver genes, suggesting that many fusions are dispensable for tumor cell fitness. Novel therapeutically actionable fusions involving RAF1, BRD4 and ROS1 were verified in new histologies. In addition, recurrent YAP1-MAML2 fusions were identified as activators of Hippo-pathway signaling in multiple cancer types, supporting therapeutic targeting of Hippo signalling. Our approach discriminates functional fusions, identifying new drivers of carcinogenesis and fusions that could have important clinical implications.SignificanceWe identify fusions as new potential candidates for drug repurposing and drivers of carcinogenesis. These results support histology agnostic marker-driven precision cancer medicine. Most fusions are not functional with implications for interpreting cancer fusions reported from clinical sequencing studies.
Does online shopping make consumers feel better? Exploring online retail therapy effects on consumers’ attitudes towards online shopping malls
Authors: Lee Jihyun , Lee Yuri 
Published: February 2019

Purpose
The purpose of this paper is to examine the relationship between online retail therapy and consumers’ attitudes towards online fashion shopping malls (ATO) based on the stimulus–organism–response model.

Design/methodology/approach
This study examined how online retail therapy factors (e.g. the aesthetics of web design and attractiveness of the models) affect consumers’ ATO. In particular, the authors examined the mediation of positive mood reinforcement (PMR) and negative mood reduction (NMR).

Findings
The results indicated that aesthetics has a significant and direct effect on ATO. However, model attractiveness has an indirect effect on ATO through PMR and NMR. In addition, the direct effect of aesthetics on ATO is greater than the indirect effect of model attractiveness. Therefore, online fashion shopping malls need to concentrate on improving the aesthetics of the shopping malls. For fashion shopping malls that do not have the capacity to improve the aesthetics, it is possible to improve ATO by using highly attractive models.

Originality/value
This study applied the concept of retail therapy to the online environment and verified the effect. This study expanded the scope of the study of retail therapy by examining the effect of mood improvement on ATO as well. Further, this study examined the structure of two online retail therapy factors, aesthetics and model attractiveness, that affect ATO through PMR and NMR, and suggested managerial implications for online shopping malls.
Audit fees, perceived audit risk, and the financial crisis of 2008
Authors: Chen Hanmei , Hua Shaowen , Liu Zenghui , Zhang Mei 
Published: February 2019

Purpose
The purpose of this paper is to investigate how audit fees change in responding to the financial crisis of 2008. It also examines auditors’ perceived risk and how they priced the risk in the financial crisis.

Design/methodology/approach
Using a sample of 20,930 firm-year observations, this paper examines the change of audit fees before, during and after the financial crisis, as well as the relationship between audit fees and restatements. Furthermore, this study investigates whether this relationship between audit fees and restatements strengthened during the financial crisis.

Findings
The paper finds that audit fees increase as a result of the macro-systemic risks from the crisis. It also finds that there is a significantly positive relationship between audit fees and restatements, which is a proxy of risk factors related to poor financial reporting quality and poor audit quality. However, the results show that there is no significant change of the fees–restatements relationship in the financial crisis period.

Research limitations/implications
The main limitation of this study is that no definite answer can be provided for the question that whether auditors believe that poor audit quality and audit failures are leading up to the financial crisis. The test rejects the alternative hypothesis. However, it does not necessarily prove the null hypothesis is true.

Originality/value
This paper contributes to the current literature by analyzing not only the impact of the financial crisis on audit fees, but also how the accounting profession views its own role in the financial crisis.
Rules of (household) engagement: technology as manager, assistant and intern
Authors: Letheren Kate , Russell-Bennett Rebekah , Mulcahy Rory Francis , McAndrew Ryan 
Published: February 2019

PurposePractitioners need to understand how households will engage with connected-home technologies or risk the failure of these innovations. Current theory does not offer sufficient explanation for how households will engage; hence, this paper aims to address an important gap by examining how households set “rules of engagement” for connected-home technologies in the context of electricity use and monitoring.Design/methodology/approachA review of the extant psychology, technology and engagement literature is conducted and yields two research questions for exploration. The research questions are addressed via 43 in-depth household interviews. Analysis includes thematic analysis and computerized text analysis.FindingsThe results include a typology of technology engagement (the “PIP typology”) and discuss three main roles for technology in assisting households: intern, assistant and manager. Key contributions are as follows: consumers in household settings may experience “compromised engagement” where the perceived middle option is selected even if no-one selected that option originally; households open to using connected-home technologies are often taking advantage of their ability to “delegate” engagement to technology, and because consumers humanize technology, they also expect technology to follow social roles and boundaries.Research limitations/implicationsFuture research may examine the PIP typology quantitatively and/or in different contexts and would benefit from a longitudinal study to examine how household technology engagement evolves. Four research propositions are provided, which may form the basis for future research.Practical implicationsRecommendations for practitioners are presented regarding the benefits of keeping consumers at the heart of connected-home technology goods and services. Specific design principles are provided.Originality/valueThis paper fulfills the need to understand how households will engage with connected-home technologies and the roles this technology may fulfill in the complex household service system.
The status of entrepreneurship education in Jordanian universities
Authors: Alakaleek Wejdan 
Published: February 2019

Purpose
The purpose of this paper is to examine the developmental level of entrepreneurship education within the context of Jordanian higher education. The level of development in such education is investigated based on two areas: the educational courses and programs themselves and the formal structures within which they are embedded.

Design/methodology/approach
The quantitative approach is based on a survey scan of all 29 Jordanian universities, including their course plans, educational programs, departments and centers. A list of entrepreneurship centers, programs and course subjects is provided and analyzed.

Findings
The main findings of study are: in Jordan, entrepreneurship education is still at an early stage of development, and its offerings are limited to a few courses covering some introductory subjects in small business and entrepreneurship courses. Of the Jordanian universities, one university offers a major educational graduate program in entrepreneurship and 27.5 percent have centers for innovation and entrepreneurship, but lack any entrepreneurship departments. Entrepreneurship education is new in Jordan: the first provided course was a small business management; the first center was established in 2004 and later in 2012, it offered the first educational programs in entrepreneurship.

Research implications
This paper assists all stakeholders in higher education to build an understanding of the nature of entrepreneurship education in Jordan and supports the design of appropriate strategies for encouraging entrepreneurial subjects to be incorporated into the country’s universities educational programs.

Originality/value
The value of this study stems from its aim to provide an overview of the status of entrepreneurship education in Jordanian universities. It also makes a contribution to knowledge as the first nationwide study in this context.
Analysis of patients’ attitudes towards medical service prices in different regions based on grey relational theory
Authors: Zhang Chongxu , Duan Lizhong , Liu Hangyu , Zhang Yinran , Yin Lili , Sun Qiaoqiao , Lu Qi 
Published: February 2019

PurposeThe purpose of this paper is to understand the attitude of patients towards the current medical service price and the effect of policy implementation, and explore the existing problems of the current medical service price policy in the region in order to provide a research basis for the dynamic adjustment mechanism of the medical service price.Design/methodology/approachLiterature analysis and expert interviews are used to design the questionnaire of the dynamic adjustment of medical service price formation mechanism. A convenient sampling method is used to extract data of 600 patients from the five areas, namely Beijing, Tianjin, Hebei, Shandong and Liaoning, on-site to fill out the paper-based questionnaire and electronic questionnaire. The grey relational analysis is used to explore the difference in the attitudes of patients towards the price of the medical service. Combined with the research results and expert interview results, some improvement suggestions related to the current price policy of medical service in five areas are put forward.FindingsThe overall average score of respondents in the five areas, namely Beijing, Tianjin, Hebei, Shandong and Liaoning, is found to be 3.861. In terms of surgical operation fee and examination fee, the average score is higher than 4, i.e. 4.097 and 4.011, respectively, indicating “relatively high” nodes. According to grey relevancy sorting, the correlation between the health service price attitude and the overall score in the five regions is in the following order: Shandong > Tianjin > Beijing > Liaoning > Hebei.Originality/valueIn this study, patients’ attitude towards the current price of medical services in their local areas, Beijing, Tianjin, Hebei, Shandong and Liaoning, is investigated in order to explore the existing problems of medical service price reform and thus provide the basis for further improvement in the medical service price policy.
Management of perinatal depression with non-drug interventions
Authors: Johansen Sara L , Robakis Thalia K , Williams Katherine Ellie , Rasgon Natalie L 
Published: February 2019

ABSTRACTPerinatal depression is a common disorder that has been associated with serious risks to mother and child. Recently, screening for depression in pregnant and postpartum women has increased, as has the development of new psychotherapy and non-drug treatment modalities. Matching patients to treatments can be challenging, and although research into personalized treatment of major depression in the general population has increased, no published guidelines focus on personalized treatment approaches to perinatal depression. In particular, guidelines on non-drug treatments are lacking. This review summarizes the evidence on personalized non-drug treatment of perinatal depression, how to incorporate patients’ preferences, novel treatments under investigation, and the potential role of biomarkers in matching patients to treatment. The review provides recommendations for future research in personalized care of perinatal depression.
Protocol for a prospective cohort study of assessing postoperative cognitive changes after total hip and knee arthroplasty in the Greater Toronto area
Authors: Choi Stephen , Avramescu Sinziana , Orser Beverley A , Au Shelly 
Published: February 2019

IntroductionCognitive changes after anaesthesia and surgery, such as delirium and postoperative cognitive dysfunction (POCD), are common and lead to poor outcomes and increased healthcare costs. While several interventions for delirium exist, there are no effective treatment strategies for POCD. Understanding the risks and contributing factors may offer clinicians unique opportunities to better identify and develop preventative interventions for those at higher risk. Elderly patients undergoing orthopaedic surgery are at high risk of developing postoperative delirium (PD) and POCD. The incidence of POCD has not been rigorously studied in the total hip and knee arthroplasty (THA/TKA) population. Therefore, we have designed a prospective, observational cohort study to assess POCD in patients undergoing THA/TKA, both increasingly common procedures. The incidence of PD and POCD in a high volume, tertiary care arthroplasty centre will be determined and associated risk factors will be identified.Methods and analysisCognitive function will be tested with a computer-based cognitive assessment tool [CogState Brief Battery], preoperatively at baseline and postoperatively while in hospital at (<3 days), 6 weeks and 4.5 months. The primary outcome is the incidence of postoperative cognitive decline at 4.5 months. Logistic regression analysis is planned to test the association of POCD with several potential risk factors. In addition, delirium will be assessed preoperatively and postoperatively in the hospital using the Confusion Assessment Method (3D-CAM).Ethics and disseminationThe protocol for this prospective observational study was approved by the Sunnybrook Health Sciences Centre Research Ethics Board (REB#: 040–2017). Recruitment commenced in May 2017 and will continue until 2019. The results will be disseminated in a peer-reviewed journal and in scientific meetings.Trial registration numberNCT03147937.