bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral imbalanced TFH/TFR ratio correlates with intrathecal IgG synthesis in multiple sclerosis at clinical onset
Authors: Puthenparampil Marco , Zito Antonio , Pantano Giorgia , Federle Lisa , Stropparo Erica , Miante Silvia , De Silvestro Giustina , Plebani Mario , Gallo Paolo 
Published: June 2018

Background: Alteration of T-follicular helper (TFH) and regulatory (TFR) subpopulations may contribute to the development of auto-reactive B-cell. Objective: To investigate whether changes in TFH and TFR subsets are associated with abnormal IgG synthesis in blood and cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. Methods: Paired blood and CSF samples were obtained from 31 untreated relapsing-remitting multiple sclerosis (RRMS) patients at diagnosis. Peripheral blood TFH (CD3+CD4+CXCR5+CD25–CD127+), TFR (CD3+CD4+CXCR5+CD25+CD127dim), conventional T-Helper (TH, CD3+CD4+CXCR5–CD25–CD127+), and regulatory T-cells (T-Reg, CD3+CD4+CXCR5–CD25+CD127dim) were analyzed in all RRMS patients and in 13 healthy controls (HCs). Qualitative and quantitative intrathecal IgG synthesis was evaluated in RRMS patients, who were then further subclassified according to the presence of IgG oligoclonal bands in blood and/or CSF. Results: Compared to HC, RRMS had lower TFR percentage ( p < 0.01) and higher TFH/TFR ratio ( p < 0.001). In RRMS, TFH/TFR ratio correlated with both qualitative ( r = 0.56, p < 0.005) and quantitative intrathecal IgG synthesis (IgG Index: r = 0.78; IgGLoc: r = 0.79; IgGIF: r = 0.76, all p < 0.001). Patients with the highest TFH/TFR ratios had higher percentages of circulating B-cells (36.1 ± 35.2%, p < 0.05). Conclusion: In RRMS, increased TFH/TFR ratio associates with abnormal IgG production in blood and CSF, suggesting that antibody-producing cells, derived from deregulated peripheral germinal center reaction, colonize the CNS.
Predictors of extubation failure after open-chest cardiac surgery based on routinely collected data. The importance of a shared interprofessional clinical assessment
Authors: Sanson Gianfranco , Sartori Massimiliano , Dreas Lorella , Ciraolo Roberta , Fabiani Adam 
Published: June 2018

Background:Extubation failure (ExtF) is associated with prolonged hospital length of stay and mortality in adult cardiac surgery patients postoperatively. In this population, ExtF-related variables such as the arterial partial pressure of oxygen to fraction of inspired oxygen ratio (PaO2/FiO2), rapid shallow breathing index, cough strength, endotracheal secretions and neurological function have been sparsely researched.Aim:To identify variables that are predictive of ExtF and related outcomes.Method:Prospective observational longitudinal study. Consecutively presenting patients ( n=205) undergoing open-heart cardiac surgery and admitted to the Cardiosurgical Intensive Care Unit (CICU) were recruited. The clinical data were collected at CICU admission and immediately prior to extubation. ExtF was defined as the need to restart invasive or non-invasive mechanical ventilation while the patient was in the CICU.Results:The ExtF incidence was 13%. ExtF related significantly to hospital mortality, CICU length of stay and total hospital length of stay. The risk of ExtF decreased significantly, by 93% in patients with good neurological function and by 83% in those with a Rapid Shallow Breathing Index of ≥57 breaths/min per litre. Conversely, ExtF risk increased 27 times when the PaO2/FiO2was <150 and 11 times when it was ≥450. Also, a reassuring PaO2/FiO2value may hide critical pulmonary or extra-pulmonary conditions independent from alveolar function.Conclusion:The decision to extubate patients should be taken after thoroughly discussing and combining the data derived from nursing and medical clinical assessments. Extubation should be delayed until the patient achieves safe respiratory, oxygenation and haemodynamic conditions, and good neurocognitive function.
Orbital and nasal meningoencephaloceles secondary to chronic hydrocephalus: A rare cause of bilateral proptosis
Authors: Jenner Zachary B , Husein Nuruddin , Riascos Roy , Esquenazi Yoshua 
Published: June 2018

Introduction Orbital meningoencephalocele formation is primarily a result of congenital defects in the pediatric population and trauma of the anterior cranial fossa in adults. We present a unique case of nontraumatic nasal and orbital meningoencephaloceles presenting as bilateral proptosis with exotropia secondary to chronic hydrocephalus. Clinical presentation A 20-year-old male with a history of tuberous sclerosis, X-linked intellectual disability, and epilepsy presented to the emergency department with two days of nausea, emesis, seizures, and two months of progressive proptosis. Initial radiographs of the skull showed a “copper beaten” appearance, indicating chronically elevated intracranial pressure. Computed tomography imaging of the head demonstrated bilateral defects in the cribriform plate and anterior cranial fossa. Magnetic resonance imaging of the brain revealed triventricular hydrocephalus with meningoencephalocele extension into the nasal cavity and frontal horn herniation into the extraconal space of the orbits. The hydrocephalus was managed with ventriculoperitoneal shunt placement with rapid and complete resolution of the proptosis. Conclusion No reports have described bilateral proptosis as the presenting finding of orbital and nasal meningoencephaloceles in the absence of trauma or congenital defect. This case study demonstrates the management of meningoencephalocele formation secondary to chronic hydrocephalus.
Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells
Authors: Zhang Yankai , Paikari Alireza , Sumazin Pavel , Ginter Summarell Carly C. , Crosby Jacy R. , Boerwinkle Eric , Weiss Mitchell J. , Sheehan Vivien A. 
Published: June 2018

Key PointsFunctional studies in human primary erythroid progenitor cells support a role for FOXO3 in γ-globin regulation. Metformin treatment of human primary erythroid progenitor cells increases fetal hemoglobin in a partially FOXO3-dependent manner.
Pain Management in the Era of the Opioid Crisis
Authors: Bruera Eduardo , Del Fabbro Egidio 
Published: June 2018

PRACTICAL APPLICATIONS Recognize patients at higher risk for nonmedical opioid use. Learn about screening for chemical coping risk. Diagnose nonmedical opioid use. Manage nonmedical opioid use in the clinical oncology setting. Understand clinical criteria for referral to supportive and palliative care teams.
Wnt signaling in development and tissue homeostasis
Authors: Steinhart Zachary , Angers Stephane 
Published: June 2018

ABSTRACTThe Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis.
Effects of amniotic membrane extract and deferoxamine on angiogenesis in wound healing: anin vivomodel
Authors: Farzan Ramyar , Moeinian Mahsa , Abdollahi Alireza , Jahangard-Rafsanjani Zahra , Alipour Abbas , Ebrahimi Marzieh , Khorasani Ghasemali 
Published: June 2018

Objective:Angiogenesis, formation of new vessels from pre-existing vessels, is an essential part of wound healing. We aimed to compare amniotic membrane extract with deferoxamine in angiogenesis and to assess any synergistic effect.Method:We examined four groups of rats (five per group): control, deferoxamine, amniotic membrane extract, and deferocxamine and amniotic membrane extract in combination. A distal-based skin flap was created. Deferoxamine (100mg/kg), amniotic membrane extract (0.1mg/ml), and the combination of both were injected subcutaneously every other day in 10 separate points (0.1 ml at each point) in the skin flap. On day 11, the animals were euthanised for histopathological evaluation.Results:Results indicated that the amniotic membrane extract raised the angiogenic markers, particularly new vessel numbers (p<0.008) and CD31+ compared with controls (p <0.003), and deferoxamine increased new vessel numbers and Von Willebrand factor (vWF) significantly compared with controls (p<0.008). There was an increase in angiogenic factors in the combined group, however, this was not statistically significant difference was observed. There was no difference between amniotic membrane extract and deferoxamine.Conclusion:Amniotic membrane extract or deferoxamine could be used interchangeably in angiogenesis within wound healing due to their high safety and availability.
Dust Image Fragments Ghosts
Authors: Dürig Regina 
Published: June 2018

Abstract
‘Dust Image Fragments Ghosts’ is an artistic exploration of my view of heterotopia from a writer’s perspective, the dimension of the fragmental, and the space in between the text and the reader. The starting point are 3D micrographs of dust samples from mobile and immobile cultural artefacts, which were part of a research project which investigated the aesthetic potential of dust and its information content from the perspective of the conservation and restoration. Dust has the power to make visible the absent, to show what must have been there. Fragments as a literary form show what might be there, in between or around. ‘Dust Image Fragments Ghosts’ follows the traces of seemingly empty space. It is a reflexive literary expedition into the landscapes of dust, a ghostly universe between micro and macro, reader and writer, image and imagination.
Finding prana: Sonic experiments in search of atemporal being
Authors: Collard Helen , Jackson Philippa 
Published: June 2018

Abstract
An entire life is encompassed between a first inhale and a final exhale: breath could be said to be our physical counter of time. In Yogic philosophy, prana is a concept meaning both breath and life and pranayama is the psycho-physical practice of regulating breath. It is here, in these liminal, atemporal moments of regulation that yogic practice considers key to controlling and mastering the mind. This article outlines an interdisciplinary research collaboration between an artist/pranayama practitioner and the Brain, Performance and Nutrition Research Center at Northumbria University. This bio-art project employs the use of functional Near Infrared Spectroscopy (fNIRS) to take real-time brain-state data during a live pranayama performance. fNIRS records the relative concentration change in oxygenated and deoxygenated haemoglobin levels in each hemisphere of the brain. This is sonified in real-time. fNIRS is now a re-appropriated control system for sound controlled by the artist’s moving breath (present and temporal) and the artist’s suspended breath (absent and atemporal). This correlative sonic biofeedback installation offers auditions that explore the possibility of perhaps another perceptual modality and another kind of being in the realm of the atemporal.
The work of art in the time of technogenesis
Authors: Titmarsh Mark 
Published: June 2018

Abstract
In our current environment the digital screen has become part of the daily rhythm of work and play. Yet as those digital screens become more refined and flatter they also approach the form and presence of a painted surface. A painting is also a screen, an image bounded by an edge, portable and primarily visual. Both kinds of screens have native temporal designs that are in productive tension with each other. By fracking into their differential relationship images are shown to metabolize time, arriving out of time for the sake of an unsustainable time, concealing an end of time, hidden beneath a fantastic time beyond time. This article will develop an alternative ontology of the image through interlocked notions of time, temporality, colour and presence based on contemporary painting, the plastic arts and an uncertain relation to the visual, brought on by information communication technologies. Using the ideas of Martin Heidegger, Richard Dienst and Bernard Stiegler it will be shown that by deconstructing everyday notions of time there is a fractal proliferation of temporal modes that releases an explosive plasticity of visual presence with a hue and density held somewhere between the agency of light and the plastic materiality of the screen.
Of hooded men and buildings without pants: Negotiating the images of universal desire
Authors: Quinteros Alejandro 
Published: June 2018

Abstract
This article explores images and their incipient conflicts in today’s global consumer monoculture. Fredric Jameson pointed out that today it would be easier to imagine the end of the world before an alternative to capitalism. As we have moved towards a globalized electronic capitalist economy, the hegemony of the image is concrete as signs and symbols appear to have become universal. Conflict follows in the representations of universality as definitions diverge between publicness, imageability, fear and desire. The global speed of universal representation of the signs and symbols of Euro-America-centric hegemony powers a binary phenomenon: the geographic dislocation of the consumers of our global consumer information society and the drive towards a global homogenized consumer monoculture.
The privileges of the quasi-photographic image
Authors: Toister Yanai 
Published: June 2018

Abstract
Numerical representation enables more than efficient processability and increased programmability. As it makes obsolete qualities that have previously been used to categorize individual media it also increasingly blurs the borders between them. Therefore it should be seen as no less than surprising that many contemporary systems still use images as their exclusive output channel. An associated conundrum is the fact that, of those many images, a baffling ratio appears in photographic form. Why this persistence on familiar pseudoverisimilitude? What are the privileges of the quasi-photographic aesthetic? Much wizardry is required to make data packages look recognizable. This decision, when taken by the creators of imaging algorithms, is of course ornamental but it is also much more. In acting as mere effect quasi-photographic images can function as sophisticated ‘go-betweens’ that weave together selected aspects of the physical world with the augmented world of data in ways that other media simply cannot. Thus, perhaps it is time to consider the possibility that the quasi-photographic need not be understood only as a form of interface but also as a concession required by and for our inferior human processing capabilities.
Special effects and uncanny affect: CGI and the post-cinematic uncanny
Authors: Card William 
Published: June 2018

Abstract
This article introduces, presents and discusses the author’s practice-based artistic research. It situates the work, an investigation into the post-cinematic uncanny and the affective potential of visual effects technologies in art practice, within a theoretical context and moves towards the illumination of aspects of our relationship with certain types of digitally augmented moving imagery. The practice explores the post-cinematic uncanny as an intersection of visual arts, moving image, animation, cinema, television and visual effects linking it to theories of affect and post-cinema. It questions the nature and qualities of moving image in the twenty-first century, especially the pervasive and ubiquitous nature of computer-generated imagery (CGI) that supplements and augments digitally captured footage. In doing so it creates, explores and situates the post-cinematic uncanny within contemporary arts practice. The work employs technologies that were, until relatively recently, the preserve of high-end visual effects productions and aims to engender uncanny affect in its audience. It thus falls under the purview of Steven Shaviro’s speculations on post-cinematic affect. Shaviro’s ‘post-cinematic’ refers to the transformation of moving image practice and culture driven in part by the move to digital acquisition, manipulation, distribution, display and networked consumption. It provides a conceptual framework for this practice in relation to the wider context of cinema and moving image production. In the practice, visual effects technologies are employed site-specifically to create the impression of unknown yet familiar forms within the screen-space, creating new associations, fantastic implied narratives and extra-dimensional implications in otherwise mundane spaces. Still further removed from the profilmic event, these computer-generated images have no connection to the profilmic beyond an urge towards the ‘paradox of perceptual realism’. In this respect, CGI visual effects imagery may be analogous to Freud’s uncanny ‘double’.
Seleksi Bakteri Endofit Penghasil Senyawa Metabolit untuk Pengendalian Cendawan Patogen Terbawa Benih Jagung
Authors: Hanif Andini , Soekarno Bonny Poernomo Wahyu , Munif Abdul 
Published: June 2018

Endophytic bacteria have been reported to produce metabolite as antifungal compound. This study was aimed to obtain endophytic bacteria which are able to produce metabolite to control Fusarium sp., a potential seedborne fungi on maize. Endophytic bacteria were screened by hypersensitive test on tobacco leaves and antagonistic test. Endophytic bacteria isolates with high growth inhibitor activity were selected and examined for their metabolite compound. Thre isolates, i.e. Lactobacillus sp. isolate EF14III, Pseudomonas sp. isolate ER1I, dan Aeromonas sp. isolate ER10I has the potential to inhibit Fusarium sp.. Metabolite compound of Pseudomonas sp. isolates ER1I was able to decrease the infection Fusarium sp. by 65.0% in blotter test and decreased infection of Fusarium sp. up to 59.5% and 60.5% in growing on test using water agar and sterile soil, respectively. Cyclohexanone with concentration of 9.68% produced by Pseudomonas sp. isolat ERI1 may play a role as antifungal compound.
Penekanan Perkembangan Penyakit Bercak Ungu pada Bawang Merah oleh Cendawan Mikoriza Arbuskula
Authors: Sari Marlina Puspita , Hadisutrisno Bambang , Suryanti Suryanti 
Published: June 2018

Arbuscular mycorrhizal fungi (AMF) is known to improve the growth of shallot (Allium cepa var. aggregatum) and strengthen the resistance of plants toward disease infection. This research aimed to find out the roles of AMF in suppressing the development of purple blotch disease caused by Alternaria sp. on shallot in Caturtunggal, Sleman, Yogyakarta. Inoculation of AMF either on fertilization of N, P, K or without fertilization treatment resulted on higher plant height and number of leaves compared to those without AMF inoculation. The plant inoculated with AMF had lower purple blotch disease intensity and disease progression than control and fungicide treatment. The result showed that AMF, in addition to act as the bio-fertilizer, is a potential to be a biocontrol agent.
Peran Mikoriza Arbuskula pada Insidensi Penyakit Busuk Pangkal Batang Lada
Authors: Halim Halim , Mariadi Mariadi , Karimuna La , Hasid Rachmawati 
Published: June 2018

Stem rot or foot rot disease caused by Phytophthora capsici is known as an important constraint on pepper cultivation. Research was conducted to determine the effect of arbuskula mycorhizal fungi (AMF) on incidence of foot rot disease of pepper seedlings. The experiment was done in the net house and arranged using completed randomized design with 6 treatments, i.e. (1) soil infested by P. capsici (TPC) as negative control treatment, (2) sterilized soil (TS) as positive control treatment, (3) TPC with 5 g of AMF, (4) TPC with 10 g AMF, (5) TPC with 15 g AMF, and (6) TPC with 20 g AMF. Observation involved plant height, number of shoots, disease incidence, the percentage of AMF infection on the roots of pepper plants, and pepper plants dependence on AMF. The results showed that the application of AMF at a dose of 20 g per 10 kg of soil effectively suppressed incidence of foot rot disease and improve plant growth
Deteksi Virus Terbawa Umbi Benih pada Bawang Merah Kultivar Biru Bantul
Authors: Nurviani Nurviani , Sulandari Sri , Somowiyarjo Susamto , Subandiyah Siti 
Published: June 2018

Virus infection on shallots may cause mosaic of leaves and plant dwarf. It is very important to know the identity of the virus as a requirement in determining viral disease management strategy. The research is subjected to identify seed- transmitted viruses from shallot bulbs. Detection of virus from bulb was conducted by growing on test, followed by mechanical inoculation on shallot cultivar Biru Bantul, Chenopodium amaranticolor, and Nicotiana tabacum and morphological observation of virus particle by electron microscope. About 2 weeks after inoculation symptoms was observed, i.e. mosaic and dwarf on shallot cultivar Biru Bantul, local necrotic on C. amaranticolor, but symptomless on N. tabacum. Filamentous particles of 650 nm and 800 nm in length was observed under electron microscope from plants with mosaic and dwarfing symptom, respectively. This indicated the presence of 2 different seed-transmitted viruses on infected shallots. Two species of shallot viruses, i.e. Shallot latent carlavirus (SLV) and Onion yellow dwarf potyvirus (OYDV) was most likely the main seedborne viruses on shallot bulb. Identification based on nucleic acid and protein sequence analysis is necessary for further confirmation
Peluang Penyelesaian Sengketa Perdata Tentang Tanah Melalui Alternative Dispute Resolution
Authors: Wiguna Made Oka Cahyadi 
Published: June 2018

AbstractThe current developments, there are many land disputes that are vertical or horizontal. Issues concerning land affairs are often caused by salim claims over land rights. The intended land dispute is a civil dispute concerning the land. Achieving a win-win solution in the settlement of civil disputes over land is relatively difficult to materialize, if the settlement is resolved through a trial (litigation). The choice of law that can be chosen to obtain and realize a win-win solution in solving civil disputes over land is of course through alternative dispute resolution. By way of negotiation, mediation and conciliation. In the course of the settlement of civil disputes over land settled through alternative dispute resolution, the settlement can not ignore the applicable legal principles of the treaty. Keywords: Land civil disputes, alternative dispute resolution and principles of contract.AbstrakPerkembangan yang terjadi saat ini, banyak terjadi sengketa pertanahan yang bersifat vertikal maupun horizontal. Permasalahan mengenai pertanahan yang terjadi sering disebabkan akibat salim klaim penguasaan hak atas tanah. Sengketa tanah yang dimaksudkan adalah sengketa perdata tentang tanah. Mewujudkan win-win solution dalam penyelesaian sengketa perdata tentang tanah relatif sulit dapat terwujud, apabila penyelesaiannya diselesaikan melalui sidang peradilan (litigation). Pilihan hukum (choice of law) yang dapat dipilih untuk memperoleh dan mewujudkan win-win solution dalam menyelesaikan sengketa perdata tentang tanah tentunya adalah melalui alternative dispute resolution. dengan cara negosiasi, mediasi dan konsiliasi. Dalam rangka penyelesaian sengketa perdata tentang tanah diselesaikan melalui alternative dispute resolution, maka penyelesaiannya tidak dapat mengabaikan asas-asas hukum yang berlaku mengenai perjanjian. Kata Kunci : Sengketa perdata tanah, alternatif penyelesaian sengketa dan asas-asas perjanjian.