bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preprocedural imaging to guide transcoronary ethanol ablation for refractory septal ventricular tachycardia
Authors: Roca‐Luque Ivo , Rivas‐Gándara Nuria , Francisco‐Pascual Jaume , Rodriguez‐Sanchez Jose , Cuellar‐Calabria Hug , Rodriguez‐Palomares Jose , García‐Del Blanco Bruno , Pérez‐Rodon Jordi , Santos‐Ortega Alba , Rosés‐Noguer Ferran , Marsal Roger , Rubio Barbara , García David García‐Dorado , Moya Mitjans Angel 
Published: December 2018

AbstractBackgroundRadiofrequency ablation (RF) of ventricular tachycardia (VT) due to intramural foci has a high recurrence rate. Several techniques, such as bipolar ablation, irrigated needle ablation catheter, and retrograde coronary venous ethanol ablation have been suggested. Transarterial coronary ethanol ablation (TCEA) can also be effective. We present a case series of TCEA guided with preprocedural imaging to correlated coronary arteries and the intramural substrate.Methods and ResultsWe present three consecutive patients with previous RF of septal VT (100% male; age, 72.6 ± 11.01 years; two patients with hypertrophic cardiomyopathy, one with mechanical aortic valve prosthesis) that underwent TCEA. Cardiac magnetic resonance was performed in two patients and cardiac CT in all patients. Correlation of septal arteries with intramural substrate was analyzed before the procedure so TCEA was attempted according to this analysis. After last TCEA (6.3 ± 2.08 months) the VT burden was reduced in all patients (sum of all implantable cardioverter‐defibrillator therapies [antitachycardia pacing and shock] before and after TCEA, 15.8 ± 3.73 vs 0.97 ± 0.63 therapies/month; P = 0.02). No complications occurred during TCEA.ConclusionsTCEA completely guided with previous magnetic resonance imaging and computed tomography scan to select the coronary artery in relation to the substrate seems to be feasible as an alternative strategy in cases of intramural VT refractory to RF ablation.
No better than chance? Developments in predicting adolescent suicide, a commentary on Mars et al. (2018) and Beckman et al. (2018)
Authors: Sedgwick Rosemary , Ougrin Dennis 
Published: December 2018

Suicide is the second leading cause of death in young people aged 10–24 globally (Patton et al., 2009) and it is therefore of vital importance that we understand more about how to identify those at risk. Many of those who proceed to die by suicide will not have interacted with mental health services (Kidger et al., 2012), and therefore predictors of suicide attempts and completed suicides are relevant not only to mental health services but also to schools and communities. Despite years of research, it continues to be challenging to identify those young people who undergo transition from thinking about suicide to attempting suicide as well as those young people who undergo transition from self‐harm to completed suicide. This commentary will look at the two accompanying papers by Mars et al. (2018) and Beckman et al. (2018); which seek to increase our understanding of which children and young people may proceed to engage with self‐harm and die by suicide.
Cellular retinol‐binding protein‐1 expression increases with increasing clinical severity of alopecia areata
Authors: Elmaadawy Eman , Elgarhy Lamia H , Shareef Mohammad 
Published: December 2018

SummaryBackgroundAlopecia areata (AA) is multifactorial disease mostly autoimmune affecting anagen hair follicles. Many researchers hypothesize that adequate retinoic acid (RA) levels are important for proper hair follicle behavior. Previous animal studies revealed increase in RA synthesis proteins and decrease in RA degradation proteins in AA patients when compared with controls.ObjectiveTo evaluate cellular retinol‐binding protein‐1 expression in lesional skin of alopecia areata in comparison with controls, in an attempt to know its role in the pathogenesis of alopecia areata .MethodsImmunohistochemical expression of cellular retinol‐binding protein‐1 CRBP1 was evaluated in skin biopsies taken from lesions of alopecia areata in 30 patients and 10 normal biopsy specimens taken from skin of healthy controls (HC) who were within the same age and sex.ResultsCRBP1 expression was significantly increased in lesional alopecia areata skin in comparison with normal skin of controls (P < 0.001*). Significant positive correlation was found between expression of CRBP‐1 and percentage of hair loss in the scalp (SALT score; r = 0.840, P = <0.001).ConclusionThese results may enhance the idea of the possible role of CRBP1 in the pathogenesis of AA, and ensuring the importance of its level in AA treatment.
Comparison of 2 differently sized endoscopic biopsy forceps in the evaluation of intestinal disease in cats
Authors: Bottero Enrico , Mussi Emanuele , Pieramati Camillo , De Lorenzi Davide , Silvestri Serenella , Lepri Elvio 
Published: December 2018

BackgroundIn clinical practice, histopathological diagnosis of chronic intestinal disease is challenging because of difficulty in obtaining adequate duodenal samples. At present, no studies have investigated the influence of biopsy forceps size on sample quality in cats.ObjectivesDuodenal biopsy using larger biopsy forceps (2.4 mm) will provide higher quality samples.AnimalsFifty client‐owned cats underwent endoscopy of the upper gastrointestinal tract for evaluation of chronic gastrointestinal signs, with inflammatory bowel disease (IBD) or intestinal lymphoma as differential diagnoses.MethodsFor each cat, duodenal biopsy specimens were obtained using both small (1.8 mm) and large (2.4 mm) forceps and evaluated for adequacy, orientation, the presence of artifacts, villi morphology, the presence of inflammation, and neoplastic infiltration.ResultsThe percentage of adequate and evaluable biopsy specimens obtained using the larger forceps was significantly higher than that collected using the smaller forceps. Agreement between the forceps was variable for histological features and substantial in the case of lymphoma. However, in case of disagreement, the proper diagnosis usually was achieved only with the larger biopsy forceps.Conclusions and Clinical ImportanceUse of a larger biopsy forceps allows collection of a higher percentage of adequate and evaluable biopsy specimens compared to the commonly used smaller forceps and indirectly decreases the percentage of artifacts and increases the percentage of samples with evaluable villi. The use of a larger forceps could be helpful to obtain high‐quality samples and improve diagnostic accuracy.
Use of praziquantel to control platyhelminth parasites of fish
Authors: Bader Chris , Starling David E. , Jones Douglas E. , Brewer Matthew T. 
Published: December 2018

AbstractFish are common definitive and intermediate hosts for a variety of parasitic flatworms. In unstressed wild populations, parasitic infections often go unnoticed and are perceived to represent a lesser threat to fish health. In contrast, platyhelminth parasitism of captive fish often results in decreased weight gain and increased mortality which often necessitates chemotherapeutic treatment. The presence of platyhelminth parasites in fish tissues is not only unappealing but in some cases also represents a threat to human health. In veterinary medicine, one of the most commonly used agents with anti‐flatworm activity is praziquantel; yet, no praziquantel products are labeled for use in fish in the United States. Veterinarians may use praziquantel preparations approved for other vertebrate species under the Animal Medicinal Drug Use Clarification Act (AMDUCA). However, such extra‐label use should be informed by scientific evidence including efficacy and tissue residue studies. Herein, we review studies testing the efficacy of praziquantel for treatment of platyhelminthes along with an assessment of routes of administration, pharmacokinetics, and toxicity information.
Neuropsychological Differences Among Students With Learning Difficulties, Without Learning Difficulties, and With High Capacity
Authors: Martín‐Lobo Pilar , Santiago‐Ramajo Sandra , Vergara‐Moragues Esperanza 
Published: December 2018

ABSTRACTProgress in applied neuroscience and neuropsychology in the educational context has revealed efficient methodologies for preventing academic failure and developing the potential of students. The aim of this work is to adopt a neuropsychological perspective to study learning‐related differences between students with learning difficulties (LD), without LD, and with high capacity. We evaluated visual, auditory, motor, touch, writing, language, and memory functionality in 156 students between 5 and 8 years of age. The results of the 3 × 4 factorial analysis (p < .01) and the effect size (η2p) indicate a medium‐large interaction effect between the three groups of subjects and the school year (most of the students with LD have lower scores in the neuropsychological areas evaluated than students with high abilities). These findings also hint at novel research areas for preventing academic failure and developing student capacities from a neuropsychological perspective based on basic cognitive functions.
Clinicopathologic study on a rare variant of ameloblastoma with basal cell features
Authors: You Zhu , Sun Lisha , Yan Xiaocui , Zhang Jianyun , Du Jing , Li Tiejun , Zhao Huaqiang 
Published: December 2018

AbstractObjectivesTo investigate the clinical features, pathologic manifestations, and biologic behaviors of a variant of ameloblastoma with basal cell features (AM‐BC).Materials and methodsFollowing retrospective review of the clinical and pathological data of six cases of AM‐BC, we described their histological and immunohistochemical (IHC) features and discussed the biologic behaviors, prognoses, pathogenesis, and clinical relevance of AM‐BC. Direct sequencing of polymerase chain reaction products was also performed in all cases.ResultsThe six cases of AM‐BC involved four women and two men, aged 22–82 years. Four lesions occurred in the maxilla and two in the mandible. Histologically, the basal cells tended to be arranged as unequally sized follicles, strands, or cords of odontogenic epithelium in the connective tissue stroma. Little or no stellate reticulum was present in the central portion of the nest. Expression of CKs was consistent with other histological variants of ameloblastoma (AM), but AM‐BC had significantly higher p53 and Ki‐67 (p < 0.05) labeling indices than other histological variants of AM. Two patients had BRAF gene mutations.ConclusionAmeloblastoma with basal cell features is a very rare variant of AM. Our study showed the differences and relationships that exist between AM‐BC and other variants of AM, which could enhance understanding of AM‐BC.
Effects of Xerostom® products on xerostomia in primary Sjögren’s syndrome: A randomized clinical trial
Authors: López‐Pintor Rosa María , Ramírez Lucía , Serrano Julia , de Pedro Miguel , Fernández‐Castro Mónica , Casañas Elisabeth , Hernández Gonzalo 
Published: December 2018

AbstractObjectivesTo assess the effects of Xerostom® toothpaste and mouthwash in primary Sjögren's syndrome (pSS) patients with xerostomia.Subjects and MethodsA double‐blinded, randomized study where patients were assigned at baseline test or control products. Patients used the products 3 times/day/28 days. We used a visual analogue scale (VAS) for xerostomia and an Oral Health Impact Profile‐14 (OHIP‐14), baseline and after treatment, to assess possible improvement.ResultsA total of 28 patients with pSS were included in this study, but only 24 finished it (all women, mean age 55.21 ± 11.87), and 13 patients received the test and 11 the control. VAS and OHIP‐14 scores decreased in both groups after treatment but significant differences between groups were not found. We do not detect VAS intragroup significant differences before and after treatment in test and control groups. A significant improvement in OHIP‐14 was identified in the treatment group, while no significant differences were observed in the control group. No adverse effects were present.ConclusionsXerostom® toothpaste and mouthrinse may alleviate and improve quality of life without associated side effects, but further research with a larger number of participants and follow‐up are necessary to establish the positive efficacy of these topical products in pSS patients.
The impact of pediatric atopic dermatitis on families: A review
Authors: Yang Eric J. , Beck Kristen M. , Sekhon Sahil , Bhutani Tina , Koo John 
Published: December 2018

AbstractBackgroundAtopic dermatitis (AD) is an extremely common childhood disease, with considerable impact on the quality of life of affected children and their families. While pruritus is the hallmark symptom of this disease, AD has been well‐documented to impact patients beyond physical symptoms, resulting in behavior problems, mood disorders, and sleep disturbance.ObjectiveThis literature review outlines how atopic dermatitis impacts the quality of life of families of children affected by AD.MethodsA total of 3436 articles were identified via an online search of the MEDLINE health literature database and were screened for relevance to quality of life impacts on families with children affected by AD.ResultsCaring for children affected by AD can be an extremely time‐consuming task that can impair personal relationships, decrease psychosocial functioning, and cause sleep loss among family members of affected patients. Additionally, AD may result in work absence or decreased work productivity for caregivers. Special diets, irritant and allergen avoidance strategies, and alternative therapies are commonly used by patients to manage their disease and require large amounts of family involvement.ConclusionsAtopic dermatitis can greatly decrease quality of life of families of affected children in various domains, including sleep, finances, and relationships. Early intervention and psychotherapy may be needed in some patients to address these quality of life impairments.
“Slime” dermatitis, a fad‐associated chronic hand dermatitis
Authors: Kondratuk Katherine E. , Norton Scott A. 
Published: December 2018

Abstract“Slime” is the colloquial name for a non‐Newtonian viscoelastic putty‐like substance that is currently a popular plaything among pre‐teens and adolescents. Several ingredients in homemade slime recipes may cause irritant or allergic contact dermatitis. We report two children who developed slime‐associated chronic hand dermatitis, more prominently on their dominant hand. We review the potential for irritant and allergic contact dermatoses as the causes of dermatitis associated with homemade slime.
Crossing the line: Sexual misconduct by nurses reported to the National Practitioner Data Bank
Authors: AbuDagga Azza , Wolfe Sidney M. , Carome Michael , Oshel Robert E. 
Published: December 2018

AbstractObjectiveThe objective of this study was to examine nurse sexual‐misconduct–related reports in the National Practitioner Data Bank (NPDB) and to compare them with reports for other types of offenses.Design and PopulationWe analyzed NPDB’s reports of adverse state nursing board licensure actions and malpractice payments for all nurses from January 1, 2003, to June 30, 2016.ResultsOverall, 882 nurses had sexual‐misconduct–related reports. Most were aged 35–54 (63.2%), male (63.2%), and registered or advanced practice nurses (61.5%). The disciplinary actions noted in the 988 nurse sexual‐misconduct–related licensure reports were more frequently serious than those noted in the 207,023 reports for other offenses committed by nurses (90.8% vs. 74.8%, respectively; p < 0.001). Of the 33 nurses with sexual‐misconduct–related malpractice‐payment reports, 48.5% were not disciplined by any state board of nursing for these offenses. Three‐quarters of the victims in the 47 sexual‐misconduct–related malpractice‐payment reports were female, with “emotional injury only” reported as the severity of injury in 91.5% of these reports.ConclusionsVery few nurses have been reported to the NPDB due to sexual misconduct. We welcome a zero‐tolerance standard against sexual misconduct involving patients by all types of health care professionals, including nurses.
Efficacy of group intervention involving physical activity on subjective well‐being of elderly returnees after evacuation following the Great East Japan Earthquake
Authors: Moriyama Nobuaki , Iwasa Hajime , Orui Masatsugu , Kuroda Yujiro , Ono Michiko , Okazaki Kanako , Takamura Motoaki , Sato Noriko , Yasumura Seiji 
Published: December 2018

AimIn general, physically activity contributes to better subjective well‐being (SWB) in the elderly. However, the physical activity level of older people who experienced relocation after the Great East Japan Earthquake has been reported to be low, possibly leading to low SWB. This study aimed to examine the efficacy of group intervention involving physical activity on SWB among older returnees after the Great East Japan Earthquake.MethodsThe participants were randomly allocated to an intervention group (4 men, 10 women) or a control group (7 women). Participants in the intervention group attended a series of weekly classes over eight weeks to encourage daily physical activity, whereas participants in the control group received no intervention. SWB, the primary outcome, was assessed by the World Health Organization Five Well‐Being Index.ResultsMedian variation in the World Health Organization Five Well‐Being Index scores at 3 months from the baseline in the intervention and control groups was −1.0 and −2.0 points, respectively; the difference was borderline significant (P = 0.06). There was no significant difference between the groups in the median of variation in muscle strength (P = 0.79) or mobility (P = 0.77) at 3 months.ConclusionThe intervention might prevent deterioration in participants’ SWB. Further studies involving older returnees with poor physical activity and/or sedentary lifestyle may be beneficial for health promotion in the area.
Estuarine clay mineral distribution: Modern analogue for ancient sandstone reservoir quality prediction
Authors: Griffiths Joshua , Worden Richard H. , Wooldridge Luke J. , Utley James E. P. , Duller Robert A. , Edge Rhiannon L. 
Published: December 2018

AbstractThe spatial distribution of clay minerals in sandstones, which may both enhance or degrade reservoir quality, is poorly understood. To address this, clay mineral distribution patterns and host‐sediment properties (grain size, sorting, clay fraction abundance and bioturbation intensity) have, for the first time, been determined and mapped at an unprecedentedly high‐resolution in a modern estuarine setting (Ravenglass Estuary, UK). Results show that the estuary sediment is dominated by illite with subordinate chlorite and kaolinite, although the rivers supply sediment with less illite and significantly more chlorite than found in the estuary. Fluvial‐supplied sediment has been locally diluted by sediment derived from glaciogenic drift deposits on the margins of the estuary. Detailed clay mineral maps and statistical analyses reveal that the estuary has a heterogeneous distribution of illite, chlorite and kaolinite. Chlorite is relatively most abundant on the northern foreshore and backshore and is concentrated in coarse‐grained inner estuary dunes and tidal bars. Illite is relatively most abundant (as well as being most crystalline and most Fe–Mg‐rich) in fine‐grained inner estuary and central basin mud and mixed flats. Kaolinite has the highest abundance in fluvial sediment and is relatively homogenous in tidally‐influenced environments. Clay mineral distribution patterns in the Ravenglass Estuary have been strongly influenced by sediment supply (residence time) and subsequently modified by hydrodynamic processes. There is no relationship between macro‐faunal bioturbation intensity and the abundance of chlorite, illite or kaolinite. Based on this modern‐analogue study, outer estuarine sediments are likely to be heavily quartz cemented in deeply‐buried (burial temperatures exceeding 80 to 100°C) sandstone reservoirs due to a paucity of clay grade material (<0·5%) to form complete grain coats. In contrast, chlorite‐enriched tidal bars and dunes in the inner estuary, with their well‐developed detrital clay coats, are likely to have quartz cement inhibiting authigenic clay coats in deeply‐buried sandstones.
Dichotomy of Notch signalling in regulating tumour immune surveillance
Authors: Khosla Ritu , Vyas Ashish Kumar , Trehanpati Nirupma 
Published: December 2018

AbstractNotch signalling is an evolutionarily conserved multifaceted pathway that controls diverse cellular processes. Its role in regulating development and tissue homeostasis is well established. Aberrant activation of the Notch pathway has been implicated in the initiation and progression of many types of cancers. However, although in some cancers Notch signalling acts as a tumour‐promoter, in others it is reported to suppress tumour growth and progression. Accumulating evidence suggests the involvement of both the innate and adaptive immune system in the development of various tumours. Currently, extensive studies on investigating the effects of Notch signalling in tumour immune surveillance are being carried out. Interestingly, recent literature shows how the changing expression of Notch genes in different T cell subsets like CD4 and CD8 helps in controlling anti‐tumour immune responses. In this review, we discuss in depth the roles of Notch signalling molecules and different immune cells in the context of the tumour microenvironment. We also outline how current knowledge can be exploited to develop novel therapies in order to control the propagation of cancer stem cells.
A pepper RING‐type E3 ligase, CaASRF1, plays a positive role in drought tolerance via modulation of CaAIBZ1 stability
Authors: Joo Hyunhee , Lim Chae Woo , Lee Sung Chul 
Published: December 2018

SummaryPlants have evolved complex defense mechanisms to adapt and survive under adverse growth conditions. Abscisic acid (ABA) is a phytohormone that plays a pivotal role in the stress response, especially regulation of the stomatal aperture in response to drought. Here, we identified the pepper CaASRF1 (Capsicum annuum ABA Sensitive RING Finger E3 ligase 1) gene, which modulates drought stress tolerance via ABA‐mediated signaling. CaASRF1 contains a C3H2C3‐type RING finger domain, which functions as an E3 ligase by attaching ubiquitins to the target proteins. CaASRF1 expression was enhanced after exposure to ABA, drought and NaCl. Loss‐of‐function in pepper plants and gain‐of‐function in Arabidopsis plants revealed that CaASRF1 positively modulates ABA signaling and the drought stress response. Moreover, CaASRF1 interacted with and was associated with degradation of the bZIP transcription factor CaAIBZ1 (Capsicum annuum ASRF1‐Interacting bZIP transcription factor 1). Contrary to CaASRF1 phenotypes, CaAIBZ1‐silenced pepper and CaAIBZ1‐overexpressing Arabidopsis exhibited drought‐tolerant and drought‐sensitive phenotypes, respectively. Taken together, our data indicate that CaASRF1 positively modulates ABA signaling and the drought stress response via modulation of CaAIBZ1 stability.