bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway
Authors: Moon Jeonghyeon , Cho Keun-Hyung , Jhun JooYeon , Choi JeongWon , Na Hyun-Sik , Lee Jeong Su , Lee Seung Yoon , Min Jun-Ki , Shetty Anan , Park Sung-Hwan , Kim Seok Jung , Cho Mi-La 
Published: November 2024

Abstract
Objective
Osteoarthritis (OA) is a degenerative joint disease caused by the breakdown of joint cartilage and adjacent bone. Joint injury, being overweight, differences in leg length, high levels of joint stress, abnormal joint or limb development, and inherited factors have been implicated in the etiology of OA. In addition to physical damage to the joint, a role for inflammatory processes has been identified as well. Small heterodimer partner-interacting leucine zipper protein (SMILE) regulates transcription and many cellular functions. Among the proteins activated by SMILE is the peroxisome proliferator-activated receptor (PPAR) γ, which mediates the activities of CD4 + T helper cells, including Th1, Th2, and Th17, as well as Treg cells. PPAR-γ binds to STAT3 to inhibit its transcription, thereby suppressing the expression of the NF-κB pathway, and in turn, the expression of the inflammatory cytokines interferon (IFN), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, which are sub-signals of STAT3 and NF-κB.

Methods
OA was induced in control C57BL/6 mice and in C57BL/6-derived SMILE-overexpressing transgenic (SMILE Tg) mice. The protein expression levels in the joint and spleen tissues were analyzed by immunohistochemistry and immunofluorescence images. In addition, flow cytometry was performed for detecting changes of the changes of immune cells.

Results
Less cartilage damage and significantly reduced levels of OA biomarkers (MMP13, TIMP3 and MCP-1) were observed in SMILE Tg mice. Immunohistochemistry performed to identify the signaling pathway involved in the link between SMILE expression and OA revealed decreased levels of IL-1β, IL-6, TNF-α, and phosphorylated AMPK in synovial tissues as well as a significant decrease in phosphorylated STAT3 in both cartilage and synovium. Changes in systemic immune cells were investigated via flow cytometry to analyze splenocytes isolated from control and SMILE Tg mice. SMILE Tg mice had elevated proportions of CD4 + IL-4 + cells (Th2) and CD4 + CD25 + Foxp3 + cells (Treg) and a notable decrease in CD4 + IL-17 + cells (Th17).

Conclusion
Our results show that overexpressed SMILE attenuates the symptoms of OA, by increasing AMPK signaling and decreasing STAT3, thus reducing the levels of inflammatory immune cells.
TRIM28 regulates the coagulation cascade inhibited by p72 of African swine fever virus
Authors: Zhu Xuejiao , Li Fang , Fan Baochao , Zhao Yongxiang , Zhou Junming , Wang Dandan , Liu Renqiang , Zhao Dongming , Fan Huiying , Li Bin 
Published: November 2024

AbstractIn 2018, African swine fever virus (ASFV) emerged in China, causing extremely serious economic losses to the domestic pig industry. Infection with ASFV can cause disseminated coagulation, leading to the consumption of platelets and coagulation factors and severe bleeding. However, the mechanism of virus-induced coagulation has yet to be established. In our study, ASFV downregulated the coagulation process, as detected by D-dimer (D2D) and Factor X (F10) expression in pigs challenged with ASFV HLJ/18. In vitro, ASFV infection increased Factor IX (F9) and Factor XII (F12) expression while downregulating F10 expression in porcine alveolar macrophages (PAMs). African swine fever virus induced both intrinsic and extrinsic coagulation cascades. In addition, several encoded proteins affect the expression of the crucial coagulation protein F10, and among the encoded proteins, p72 inhibits the activity and expression of F10. Proteomic analysis also revealed that p72 is involved in the coagulation cascade. p72 can interact with F10, and its inhibitory functional domains include amino acids 423–432 and amino acids 443–452. Finally, we found that F10 and p72 interact with tripartite motif-containing protein 28 (TRIM28). TRIM28 knockdown resulted in a decrease in F10 expression. Importantly, TRIM28 contributes to the reduction in F10 protein expression regulated by p72. Our findings revealed an inhibitory effect of the viral protein p72 on the ASFV infection-induced coagulation cascade and revealed a role of TRIM28 in reducing F10 expression, revealing a molecular mechanism of ASFV-associated coagulation.
Steered Response Power for Sound Source Localization: a tutorial review
Authors: Grinstein Eric , Tengan Elisa , Çakmak Bilgesu , Dietzen Thomas , Nunes Leonardo , van Waterschoot Toon , Brookes Mike , Naylor Patrick A. 
Published: November 2024

AbstractIn the last three decades, the Steered Response Power (SRP) method has been widely used for the task of Sound Source Localization (SSL), due to its satisfactory localization performance on moderately reverberant and noisy scenarios. Many works have analysed and extended the original SRP method to reduce its computational cost, to allow it to locate multiple sources, or to improve its performance in adverse environments. In this work, we review over 200 papers on the SRP method and its variants, with emphasis on the SRP-PHAT method. We also present eXtensible-SRP, or X-SRP, a generalized and modularized version of the SRP algorithm which allows the reviewed extensions to be implemented. We provide a Python implementation of the algorithm which includes selected extensions from the literature.
Interactive effects of intangible cultural heritage and tourism development: a study based on the data panel PVAR model and coupled coordination model
Authors: Du Yixuan , Chen Long , Xu Jinyi 
Published: November 2024

Abstract
Exploring the coordination and analysis of intangible cultural heritage (ICH) and tourism development is a key issue in advancing cultural heritage and conservation in Chinese society. This paper employs panel data from 30 Chinese provinces from 2013 to 2022, utilizing the coupled coordination degree model and the panel vector autoregression (PVAR) model. In terms of provinces and regions, the data investigates the development relationship between intangible cultural heritage and tourism. The results of the study are: 1. The degree of coupling coordination between the two has shown an increasing trend over the ten-year sample data period. In 2021 and 2022, COVID-19 will have a stronger negative impact on the coupling degree. 2. The eastern coastal provinces of China, as well as the municipal areas, have a higher level of coupling coordination. Inland provinces, such as those in central and western China, exhibit relatively lower levels of coordination. The PVAR model data reveals a positive correlation between the interactions generated by intangible cultural heritage. The development of intangible cultural heritage has a particular impact on tourism. Intangible cultural heritage, in turn, depends on its own development. We should strengthen the development of intangible cultural heritage in the future. The study's findings provide theoretical references for the coordinated development of intangible cultural heritage and tourism in China.
Application of deep learning algorithms for identifying deterioration in the ushnisha (Head Bun) of the Leshan Giant Buddha
Authors: Zhang Chaokai , Peng Ningbo , Wang Lixu , Chen Yinjia , Zhang Yue , Sun Bo , Wang Fengrui , Huang Jizhong , Zhu Ye 
Published: November 2024

Abstract
The Leshan Giant Buddha’s ushnisha (Head Bun) has suffered from loss of lime plaster, cracks, and biological damage, compromising its structural integrity and reducing the effectiveness of the drainage system in the Buddha's head. The infiltration of moisture has led to water damage within the statue, significantly accelerating its weathering. This situation urgently requires protection and reinforcement measures. Detecting deterioration in the ushnisha is a crucial step in the preservation process. In this study, we utilized two deep learning models for pixel-level semantic segmentation of the damage. Due to the small size of the cracks, a weighted loss function was applied to improve both the training speed of the model and the efficiency of crack identification. This weighting strategy proved effective for both models. The weighted K-Net model achieved a mean accuracy (mAcc) of 90.23% and a mean intersection-over-union (mIoU) of 69.55%, with a damage segmentation speed of 7 images per second, which is 1309 times faster than manual segmentation. By applying the trained deep learning models to re-examine the ushnisha, we successfully identified damage that had been overlooked during manual annotation. Using the model’s enhanced results, we conducted a comprehensive quantification of the damage across all ushnisha and identified the most severely affected areas. Additionally, we performed a model interpretability analysis to explain the decision-making process and principles of the deep learning models. This research provides significant practical value for detecting and quantifying damage in the Leshan Giant Buddha.
Examination of factors impacting spitting or vomiting among children under 5 years of age during seasonal malaria chemoprevention: a quantitative study in Burkina Faso, Chad, Nigeria and Togo
Authors: Gao Chen , Huang Sikai , Ibinaiye Taiwo , Sawadogo Benoît , Traore Adama , Compaoré Cheick Saïd , Awokou Fantche , Nnaji Chukwudi A. , Baker Kevin , Wang Duoquan , Richardson Sol 
Published: November 2024

Abstract
Background
Since 2012, the World Health Organization has recommended seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) for children aged 3–⁠59 months in regions where malaria transmission is seasonal. Full ingestion of SMC medicines without spitting or vomiting during a complete 3-day course is critical to ensure effectiveness of SMC medicines and to avoid development of antimalarial resistance. Although evidence suggests that spitting or vomiting is not rare, there is limited analytical evidence on potential factors associated with spitting or vomiting in SMC campaigns.

Methods
We utilized data from SMC coverage surveys conducted in Burkina Faso, Chad, Togo and Nigeria between 2020 and 2022. Episodes of spitting or vomiting were defined as SMC-eligible children spitting out most of the dose or vomiting the entire dose within 30 min of SPAQ administration as reported by primary caregivers. We conducted a cross-sectional study using mixed-effects logistic regression with variables including household socioeconomic variables and caregiver knowledge of SMC, to identify factors associated with spitting or vomiting.

Results
The proportion of SMC-eligible children spitting or vomiting SPAQ doses ranged from 1.81% in Nigeria to 4.36% in Chad. The odds of spitting or vomiting were lower among children administered medicines under community distributor (CD) supervision, and whose primary caregivers had a high degree of knowledge of SMC. Spitting or vomiting were negatively associated with caregiver adherence to AQ administration and caregiver reporting of children’s adverse reactions to SMC medicines. Over half of the children experiencing a spitting or vomiting episode did not receive a replacement dose from CDs. Redosing was positively associated with caregiver educational attainment, caregiver knowledge of SMC, and directly supervised medicine administration.

Conclusions
CD-supervised administration of SPAQ can strengthen community engagement strategies to enhance appropriate administration and full ingestion of SMC medicines according to the SMC delivery protocol.
Serum level of myostatin and type I interferon-inducible gene expression in dermatomyositis patients and its relation to insulin resistance
Authors: Nageeb Rania S. , Mohamed Noura Mostafa , Soliman Ahmad Sallam , Ebaid Amany M. , Mohammad Nancy Abdelhamid 
Published: November 2024

Abstract
Background
Data regarding the relation between serum myostatin level, type I interferon-inducible gene expression and insulin resistance in dermatomyositis patients are limited. This study aimed to assess serum myostatin level, homeostatic model assessment of insulin resistance (HOMA-IR) and type I interferon-inducible gene expression in dermatomyositis patients. We evaluated the role of serum myostatin level, and type I interferon-inducible gene expression in the pathogenesis of dermatomyositis as well as the relation of serum myostatin level and type I interferon-inducible gene expression to the occurrence of insulin resistance. We evaluated serum levels of myostatin and HOMA-IR utilizing ELISA as well as IFIT1 and Mx1(MxA) gene expression with RT-PCR in 25 dermatomyositis patients (group A) and 25 obviously sound subjects as controls (group B).

Results
Among group A, body mass index, serum levels of myostatin, fasting insulin, HOMA-IR, IFN-inducible genes Mx1 and IFIT1 were more significantly increased as well as; serum level of myostatin was positively correlated with age, gender, fasting insulin level, body mass index, and HOMA-IR.

Conclusions
Serum level of myostatin, Mx1 and IFIT1 gene expression act as hazard factors of insulin resistance in group A.
Total antioxidant capacity status in non-obese adolescent females with PCOS: a cross-section study
Authors: Zaki Moushira , Sherity Safenaz Y. El , Metkees Mohamed , Salem Sondos , Elnahas Tamer , Salama Ehab , Girgiss Mina Wassef , Youness Eman Refaat 
Published: November 2024

Abstract
Background
The endocrine disease polycystic ovarian syndrome (PCOS) has a number of complications. Teenagers all over the globe are becoming increasingly concerned about the syndrome. It has been suggested that oxidative stress plays a significant role in the pathogenesis of PCOS.

Aim
The purpose of the present work was to estimate total antioxidant capacity (TAC) in non-obese adolescents and decide if the TAC could be a potential marker for the prediction and diagnosis of PCOS.

Methods
Serum samples were collected to assess the levels of follicle stimulant hormone (FSH), luteinizing hormone (LH), serum lipids, and serum total antioxidant capacity (TAC) in 50 non-obese patients with PCOS and 50 controls; correlation analysis was made between serum lipid, hormonal parameters, and TAC.

Results
Adolescents with PCOS had significantly lower levels of TAC compared with controls and showed significant higher values of LH, FSH, and LH/FSH ratio. There were significant negative correlations between TAC levels with LH, FSH, and LH/FSH. Linear regression analysis revealed statistically significant correlations between TAC and LH and FSH levels in non-obese adolescents with PCOS.

Conclusion
Serum TAC level was diminished in non-obese PCOS patients and was related to increase of LH/FSH ratio. So, quantification of TAC activity in serum could be of value in assessment of cases at higher risk for development of PCOS, suggesting its possible role in regulating sex hormones and could have potential roles in the etiopathogenesis of PCOS in non-obese adolescent females.
Examining HPO by organ and system to facilitate practical use by clinicians
Authors: Dohi Eisuke , Takatsuki Terue , Tateisi Yuka , Fujiwara Toyofumi , Yamamoto Yasunori 
Published: November 2024

AbstractThe Human Phenotype Ontology (HPO) is widely used for annotating clinical text data, and sufficient annotation is crucial for the effective utilization of clinical texts. It was known that the use of LLMs can successfully extract symptoms and findings, but cannot annotate them with the HPO. We hypothesized that one of the potential issue for this is the lack of appropriate terms in the HPO. Therefore, during the Biomedical Linked Annotation Hackathon 8 (BLAH8), we attempted the following two tasks in order to grasp the overall picture of HPO. (1) Extract all HPO terms for each of the 23 HPO subclasses (defined as categories) directly under the HPO "Phenotypic abnormality" and then (2) search for major attributes in each of 23 categories. We employed LLM for these two tasks related to examining HPO and, at the same time, found that LLM didn't work well without ingenuity for tasks that lacked sentences and context. A manual search for terms within each category revealed that the HPO contains a mix of terms with four major attributes: (1) Disease Name, (2) Condition, (3) Test Data, and (4) Symptoms and Findings. Manual curation showed that the ratio of symptoms and findings varied from 0 to 93.1% across categories. For clinicians, who are end-users of medical terminology including HPO, it is difficult to understand ontologies. However, for good quality ontology is also important for good-quality data, and a clinician’s help is essential. It is also important to make the overall picture and limitations of ontologies easy to understand in order to bring out the explanatory power of LLMs and artificial intelligence.
Effect of ion temperature anisotropy on ITG mode in reversed-field-pinch plasmas
Authors: Liu Tiancheng , Liu Songfen , Jia Meixia , Kong Wei , Dong Jiaqi 
Published: November 2024

Abstract
The Ion Temperature Gradient (ITG) mode instability in the Reversed-Field-Pinch (RFP) plasmas with anisotropies in ion temperature and its gradient, is studied for the first time using the gyrokinetic integral eigenmode equation. Detailed numerical results indicate that ITG instability is reduced by ion temperature anisotropy, specifically when the temperature is higher in the direction perpendicular to the magnetic field or sufficiently high in the direction parallel to the magnetic field, with Landau damping playing a significant role. Moreover, the driving force of the ion temperature gradient in the parallel direction for the ITG mode is stronger than that in the perpendicular direction, particularly when the parallel ion temperature is higher. In addition, the study provides detailed insights into the synergistic effects of ion temperature anisotropy with magnetic shear, poloidal wave number, safety factor, and density gradient on ITG mode. It also elucidates the threshold of the ion temperature gradient necessary for mode excitation.
Superconductivity in a background of topological spin texture
Authors: Cheng Tao , Tang Dingwen , Lu Rong , Miao Jian-Jian , Chen Wei-Qiang 
Published: November 2024

Abstract
Motivated by a recent experiment on high-temperature superconductors (Wang Z. C. et al., Nature, 615, (2023) 405), we perform a theoretical study to distinguish the nature of the topological spin texture in the superconducting phase of an underdoped cuprate. We propose a phenomenological tight-binding model of electrons with spin-singlet pairing hopping in the background of topological spin texture on the square lattice to capture the coupling of electrons and the topological spin texture. Two types of topological spin texture relevant to the experiment are considered, i.e., Bloch skyrmion and sinusoidal vortex, and the Bogoliubov-de Gennes mean-field theory is employed to calculate the gap functions and local density of states. We discover an emergent d

xy
-wave component in the imaginary part of the gap function for skyrmion, but this is not present for vortex. For skyrmion, each coherent peak in the local density of states splits into two spatially uniform peaks, while for vortex, it splits into two spatially modulated peaks. Our study reveals the qualitatively different consequences of two types of topological spin texture, and can be possibly detected in the further STM experiment.
A possible exploration of the cause for the wide-range scattering of the G values
Authors: Yang Taotao 
Published: November 2024

Abstract
A statistical theory about gravity is obtained in this paper by studying the change of zero-point energy of one-dimensional vacuum caused by mass. The theory indicates that the measured value of the gravitational constant obtained by the present method is not a constant but a quantity related to acceleration and it will increase when the acceleration decreases. Our theory accords well with the experimental data by fitting high-precision measurement of the gravitational constant during the last two decades, the critical acceleration is obtained by the fitting, and the value is

, the standard error is

; the theory predicts that when the acceleration in the torsion pendulum experiment is around or less than critical acceleration, the gravitational constant value measured by the existing method will be significantly greater than the current measured value.
Weight Loss Induces Changes in Vitamin D Status in Women With Obesity But Not in Men: A Randomized Clinical Trial
Authors: Holt Rune , Holt Joachim , Jorsal Mads Joon , Sandsdal Rasmus Michael , Jensen Simon B K , Byberg Sarah , Juhl Christian Rimer , Lundgren Julie Rehné , Janus Charlotte , Stallknecht Bente Merete , Holst Jens Juul , Juul Anders , Madsbad Sten , Jensen Martin Blomberg , Torekov Signe Sørensen 
Published: November 2024

Abstract

Context
Obesity is associated with low vitamin D status -, and recent studies have suggested a difference in vitamin D metabolism between females and males.

Objective
The aim of this study was to investigate the effects of weight loss on vitamin D status in individuals with obesity, and secondarily, whether vitamin D metabolism differs between women and men.

Methods
Secondary analysis from a randomized placebo-controlled trial, designed to investigate the efficacy of 52 weeks of treatment with either liraglutide, exercise, or both combined compared with placebo on weight loss maintenance after an 8-week low-calorie diet-induced weight loss in 195 individuals with obesity (body mass index 32-43 kg/m2).

Results
The low-calorie diet-induced weight loss resulted in an increase in serum 25-hydroxyvitamin D (25(OH)D) in both women and men [12 nmol/L (95% confidence interval [CI] 9-15) and 13 nmol/L (95% CI 8-17); P &lt; .001 for both]. Women who experienced a further weight loss during the 52 weeks of intervention had an increase in serum 25(OH)D compared with women regaining weight [14 nmol/L (95% CI 6-22); P = .001]. Interestingly, women experiencing further weight loss at week 52 had a lower serum 25(OH)D at baseline compared with women regaining weight [54 nmol/L (SD 19) vs 70 nmol/L (SD 25), P &lt; .001.]

Conclusion
Weight loss induced by a low-calorie diet resulted in an increase in serum 25(OH)D in both women and men. Only in women, further weight loss had an additional beneficial impact on vitamin D. Additionally, initial low serum 25(OH)D was associated with successful weight loss maintenance in women but not men.

Trial registration
ClinicalTrials.gov number: NCT04122716