bluuebunny/crossref_metadata_2025_split huggingface dataset:
Waterproof coatings for high-power laser cavities
Authors: Cheng Xinbin , Dong Siyu , Zhi Song , Paschel Sebastian , Balasa Istvan , Ristau Detlev , Wang Zhanshan 
Published: January 2019

AbstractWith the ever-increasing laser power and repetition rate, thermal control of laser media is becoming increasingly important. Except for widely used air cooling or a bonded heat sink, water cooling of a laser medium is more effective in removing waste heat. However, how to protect deliquescent laser media from water erosion is a challenging issue. Here, novel waterproof coatings were proposed to shield Nd:Glass from water erosion. After clarifying the dependence of the waterproof property of single layers on their microstructures and pore characteristics, nanocomposites that dope SiO2 in HfO2 were synthesized using an ion-assisted co-evaporation process to solve the issue of a lack of a high-index material that simultaneously has a dense amorphous microstructure and wide bandgap. Hf0.7Si0.3O2/SiO2 multifunctional coatings were finally shown to possess an excellent waterproof property, high laser-induced damage threshold (LIDT) and good spectral performance, which can be used as the enabling components for thermal control in high-power laser cavities.
Dendritic cell vaccination plus low-dose doxorubicin for the treatment of spontaneous canine hemangiosarcoma
Authors: Konduri V. , Halpert M. M. , Baig Y. C. , Coronado R. , Rodgers J. R. , Levitt J. M. , Cerroni B. , Piscoya S. , Wilson N. , DiBernardi L. , Omarbekov Z. , Seelhoff L. , Ravi V. , Douglass L. , Decker W. K. 
Published: January 2019

AbstractAngiosarcoma is a deadly neoplasm of the vascular endothelium. Metastatic disease is often present at diagnosis, and 5-year survival is only 10–35%. Although there exist no immunocompetent mouse models of angiosarcoma with which to study immune-based approaches to therapy, angiosarcoma is a major killer of companion dogs, responsible for up to 2% of all canine deaths in some susceptible breeds or an estimated 120,000 per year in the US. The canine disease (HSA) often presents in the spleen as acute hemoabdomen secondary to splenic rupture. Even if life-saving splenectomy is performed, median overall survival (OS) is only 48 days, and 1-year survival is negligible. Here we report the analysis of a pilot phase I open-label trial of chemo-immunotherapy performed on consecutively presenting splenectomized canines with histologically verified HSA. Subjects received an abbreviated course of low-dose doxorubicin plus alpha interferon and an autologous dendritic cell-therapy reported to enhance durable CD8+memory. Disease was monitored monthly by abdominal ultrasound, chest X-ray, and echocardiogram. Median OS in the per protocol population was 109 days including one of five animals that died cancer-free at 16 months after documented resolution of relapsed disease. These results indicate that therapeutic administration of chemo-immunotherapy is both feasible and safe, substantiating the rationale for additional veterinary and human clinical studies.
GATA6 suppresses migration and metastasis by regulating the miR-520b/CREB1 axis in gastric cancer
Authors: Liu Hao , Du Feng , Sun Lina , Wu Qingfeng , Wu Jian , Tong Mingfu , Wang Xin , Wang Qi , Cao Tianyu , Gao Xiaoliang , Cao Jiayi , Wu Nan , Nie Yongzhan , Fan Daiming , Lu Yuanyuan , Zhao Xiaodi 
Published: January 2019

AbstractTranscription factors (TFs) and microRNAs (miRNAs) are tightly linked to each other in tumor development and progression, but their interactions in gastric cancer (GC) metastasis remain elusive. Here we report a novel suppressive role of GATA6 in inhibiting GC metastasis by transactivating miR-520b. We found that GATA6 expression was significantly downregulated in metastatic GC cells and tissues and that its downregulation was correlated with a poor GC prognosis. Overexpression of GATA6 suppressed GC cell migration, invasion and metastasis both in vitro and in vivo. Luciferase reporter assays and chromatin immunoprecipitation assays demonstrated that miR-520b is a direct transcriptional target of GATA6. Moreover, miR-520b expression was positively correlated with GATA6 expression in GC tissues, and ectopic expression of miR-520b inhibited the migration and invasion of GC cells. Furthermore, cAMP responsive element binding protein 1 (CREB1) was identified as a direct and functional target of miR-520b, and GATA6 could suppress GC cell migration and metastasis via miR-520b-mediated repression of CREB1. Downregulation of GATA6 and miR-520b may partly account for the overexpression of CREB1 in GC. In conclusion, our results provide novel insight into the TF-miRNA regulatory network involved in GC metastasis. Targeting the GATA6/miR-520b/CREB1 axis may be an effective approach for GC treatment.
Nanoparticle enhanced MRI can monitor macrophage response to CD47 mAb immunotherapy in osteosarcoma
Authors: Mohanty Suchismita , Yerneni Ketan , Theruvath Johanna Lena , Graef Claus Moritz , Nejadnik Hossein , Lenkov Olga , Pisani Laura , Rosenberg Jarrett , Mitra Siddhartha , Cordero Alejandro Sweet , Cheshier Samuel , Daldrup-Link Heike E. 
Published: January 2019

AbstractCD47 monoclonal antibodies (mAbs) activate tumor-associated macrophages (TAMs) in sarcomas to phagocytose and eliminate cancer cells. Though CD47 mAbs have entered clinical trials, diagnostic tests for monitoring therapy response in vivo are currently lacking. Ferumoxytol is an FDA-approved iron supplement which can be used “off label” as a contrast agent: the nanoparticle-based drug is phagocytosed by TAM and can be detected with magnetic resonance imaging (MRI). We evaluated if ferumoxytol-enhanced MRI can monitor TAM response to CD47 mAb therapy in osteosarcomas. Forty-eight osteosarcoma-bearing mice were treated with CD47 mAb or control IgG and underwent pre- and post-treatment ferumoxytol-MRI scans. Tumor enhancement, quantified as T2 relaxation times, was compared with the quantity of TAMs as determined by immunofluorescence microscopy and flow cytometry. Quantitative data were compared between experimental groups using exact two-sided Wilcoxon rank-sum tests. Compared to IgG-treated controls, CD47 mAb-treated tumors demonstrated significantly shortened T2 relaxation times on ferumoxytol-MRI scans (p < 0.01) and significantly increased F4/80+CD80+ M1 macrophages on histopathology (p < 0.01). CD47 mAb-treated F4/80+ macrophages demonstrated significantly augmented phagocytosis of ferumoxytol nanoparticles (p < 0.01). Thus, we conclude that ferumoxytol-MRI can detect TAM response to CD47 mAb in mouse models of osteosarcoma. The ferumoxytol-MRI imaging test could be immediately applied to monitor CD47 mAb therapies in clinical trials.
Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis
Authors: Jia Yugai , Tao Yu , Lv Changjun , Xia Yufeng , Wei Zhifeng , Dai Yue 
Published: January 2019

AbstractRecently, we reported that tetrandrine, a natural alkaloid, could inhibit the osteoclastogenesis and bone erosion through enhancing the ubiquitination and degradation of spleen tyrosine kinase (Syk). Herein, we addressed whether and how aryl hydrocarbon receptor (AhR) mediate the effect of tetrandrine. In vitro, tetrandrine was shown to repress RANKL-induced osteoclastogenesis and the expression of osteoclast-related marker genes, which was almost completely reversed by either AhR antagonist CH223191 or siRNA. In pre-osteoclasts, tetrandrine enhanced the ubiquitination and degradation of Syk through the AhR/c-src/c-Cbl signaling pathway, downregulated the expression of phospho-Syk and phospho-PLCγ2, and inhibited the nuclear translocation of NFATc1, a master transcription factor for osteoclastogenesis. Notably, tetrandrine acted through the non-genomic pathway of the ligand-activated AhR, as evidenced by the fact that the effect of tetrandrine did not change in the absence of AhR nuclear translocator. In collagen-induced arthritis rats, oral administration of tetrandrine decreased the number of phospho-Syk-positive cells and osteoclasts, and reduced the bone erosion in the areas of the proximal tibial epiphysis excluding the cortical bone. A combined use with CH223191 almost abolished the effect of tetrandrine. These findings revealed that tetrandrine enhanced the ubiquitination and degradation of Syk and consequently repressed the osteoclastogenesis and bone destruction through the AhR-c-src-c-Cbl pathway.
Bio-realistic synaptic characteristics in the cone-shaped ZnO memristive device
Authors: Sokolov Andrey Sergeevich , Jeon Yu-Rim , Kim Sohyeon , Ku Boncheol , Choi Changhwan 
Published: January 2019

AbstractWe demonstrate inherent biorealistic synaptic plasticity functions in the Pt/n-ZnO/SiO2–x/Pt heterostructures, where the n-ZnO semiconductor is geometrically cone-shaped in the size of a few nanometers. The synaptic functions were achieved within a two-terminal, electroforming-free, and low-power rectifying diode-like resistive switching device. The important rate-dependent synaptic functions, such as the nonlinear transient conduction behavior, short- and long-term plasticity, paired-pulse facilitation, spike-rate-dependent plasticity and sliding threshold effect, were investigated in a single device. These characteristics closely mimic the memory and learning functions of those in biosynapses, where frequency-dependent identical spiking operations are mostly taking place, and we emulate these characteristics in the “Learning-Forgetting-Relearning” synaptic behavior. The switching dynamics in the cone-shaped n-ZnO semiconductor are correlated with the transport mechanism along the grain boundaries of the charged ion species, namely, oxygen vacancies and charged oxygen. The diffusion and generation/recombination of these defects have specific time scales of self-decay by virtue of the asymmetric profile of the n-ZnO cone defects. Finally, the essential biorealistic synaptic plasticity functions were discovered for the perspectives of dynamic/adaptive electronic synapse implementations in hardware-based neuromorphic computing.
Active control of anapole states by structuring the phase-change alloy Ge2Sb2Te5
Authors: Tian Jingyi , Luo Hao , Yang Yuanqing , Ding Fei , Qu Yurui , Zhao Ding , Qiu Min , Bozhevolnyi Sergey I. 
Published: January 2019

AbstractHigh-index dielectric nanoparticles supporting a distinct series of Mie resonances have enabled a new class of optical antennas with unprecedented functionalities. The great wealth of multipolar responses has not only brought in new physical insight but also spurred practical applications. However, how to make such a colorful resonance palette actively tunable is still elusive. Here, we demonstrate that the structured phase-change alloy Ge2Sb2Te5 (GST) can support a diverse set of multipolar Mie resonances with active tunability. By harnessing the dramatic optical contrast of GST, we realize broadband (Δλ/λ ~ 15%) mode shifting between an electric dipole resonance and an anapole state. Active control of higher-order anapoles and multimodal tuning are also investigated, which make the structured GST serve as a multispectral optical switch with high extinction contrasts (>6 dB). With all these findings, our study provides a new direction for realizing active nanophotonic devices.
In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
Authors: Spence Erin F. , Dube Shataakshi , Uezu Akiyoshi , Locke Margaret , Soderblom Erik J. , Soderling Scott H. 
Published: January 2019

AbstractExcitatory synapse formation during development involves the complex orchestration of both structural and functional alterations at the postsynapse. However, the molecular mechanisms that underlie excitatory synaptogenesis are only partially resolved, in part because the internal machinery of developing synapses is largely unknown. To address this, we apply a chemicogenetic approach, in vivo biotin identification (iBioID), to discover aspects of the proteome of nascent synapses. This approach uncovered sixty proteins, including a previously uncharacterized protein, CARMIL3, which interacts in vivo with the synaptic cytoskeletal regulator proteins SrGAP3 (or WRP) and actin capping protein. Using new CRISPR-based approaches, we validate that endogenous CARMIL3 is localized to developing synapses where it facilitates the recruitment of capping protein and is required for spine structural maturation and AMPAR recruitment associated with synapse unsilencing. Together these proteomic and functional studies reveal a previously unknown mechanism important for excitatory synapse development in the developing perinatal brain.
Alveolar proteins stabilize cortical microtubules in Toxoplasma gondii
Authors: Harding Clare R. , Gow Matthew , Kang Joon Ho , Shortt Emily , Manalis Scott R. , Meissner Markus , Lourido Sebastian 
Published: January 2019

AbstractSingle-celled protists use elaborate cytoskeletal structures, including arrays of microtubules at the cell periphery, to maintain polarity and rigidity. The obligate intracellular parasiteToxoplasma gondiihas unusually stable cortical microtubules beneath the alveoli, a network of flattened membrane vesicles that subtends the plasmalemma. However, anchoring of microtubules along alveolar membranes is not understood. Here, we show that GAPM1a, an integral membrane protein of the alveoli, plays a role in maintaining microtubule stability. Degradation of GAPM1a causes cortical microtubule disorganisation and subsequent depolymerisation. These changes in the cytoskeleton lead to parasites becoming shorter and rounder, which is accompanied by a decrease in cellular volume. Extended GAPM1a depletion leads to severe defects in division, reminiscent of the effect of disrupting other alveolar proteins. We suggest that GAPM proteins link the cortical microtubules to the alveoli and are required to maintain the shape and rigidity of apicomplexan zoites.
Near-atomic structure of a giant virus
Authors: Fang Qianglin , Zhu Dongjie , Agarkova Irina , Adhikari Jagat , Klose Thomas , Liu Yue , Chen Zhenguo , Sun Yingyuan , Gross Michael L. , Van Etten James L. , Zhang Xinzheng , Rossmann Michael G. 
Published: January 2019

AbstractAlthough the nucleocytoplasmic large DNA viruses (NCLDVs) are one of the largest group of viruses that infect many eukaryotic hosts, the near-atomic resolution structures of these viruses have remained unknown. Here we describe a 3.5 Å resolution icosahedrally averaged capsid structure of Paramecium bursaria chlorella virus 1 (PBCV-1). This structure consists of 5040 copies of the major capsid protein, 60 copies of the penton protein and 1800 minor capsid proteins of which there are 13 different types. The minor capsid proteins form a hexagonal network below the outer capsid shell, stabilizing the capsid by binding neighboring capsomers together. The size of the viral capsid is determined by a tape-measure, minor capsid protein of which there are 60 copies in the virion. Homologs of the tape-measure protein and some of the other minor capsid proteins exist in other NCLDVs. Thus, a similar capsid assembly pathway might be used by other NCLDVs.
Author Correction: Remote sensing quantifies widespread abundance of permafrost region disturbances across the Arctic and Subarctic
Authors: Nitze I. , Grosse G. , Jones B. M. , Romanovsky V. E. , Boike J. 
Published: January 2019

The original version of this Article contained an error in the author affiliations. Affiliation 5 incorrectly read ‘Tyumen State Oil and Gas University, Tyumen, Tyument. Oblast, Russian Federation, 625000’.This has now been corrected in both the PDF and HTML versions of the Article.
Quantum key distribution with setting-choice-independently correlated light sources
Authors: Mizutani Akihiro , Kato Go , Azuma Koji , Curty Marcos , Ikuta Rikizo , Yamamoto Takashi , Imoto Nobuyuki , Lo Hoi-Kwong , Tamaki Kiyoshi 
Published: January 2019

AbstractDespite the enormous theoretical and experimental progress made so far in quantum key distribution (QKD), the security of most existing practical QKD systems is not rigorously established yet. A critical obstacle is that almost all existing security proofs make ideal assumptions on the QKD devices. Problematically, such assumptions are hard to satisfy in the experiments, and therefore it is not obvious how to apply such security proofs to practical QKD systems. Fortunately, any imperfections and security-loopholes in the measurement devices can be perfectly closed by measurement-device-independent QKD (MDI-QKD), and thus we only need to consider how to secure the source devices. Among imperfections in the source devices, correlations between the sending pulses and modulation fluctuations are one of the principal problems, which unfortunately most of the existing security proofs do not consider. In this paper, we take into account these imperfections and enhance the implementation security of QKD. Specifically, we consider a setting-choice-independent correlation (SCIC) framework in which the sending pulses can present arbitrary correlations but they are independent of the previous setting choices such as the bit, the basis and the intensity settings. Within the framework of SCIC, we consider the dominant fluctuations of the sending states, such as the relative phases and the intensities, and provide a self-contained information-theoretic security proof for the loss-tolerant QKD protocol in the finite-key regime. We demonstrate the feasibility of secure quantum communication, and thus our work constitutes a crucial step towards guaranteeing the security of practical QKD systems.
Deciphering the evolution of Deception Island’s magmatic system
Authors: Geyer A. , Álvarez-Valero A. M. , Gisbert G. , Aulinas M. , Hernández-Barreña D. , Lobo A. , Marti J. 
Published: January 2019

AbstractDeception Island (South Shetland Islands) is one of the most active volcanoes in Antarctica, with more than 20 explosive eruptive events registered over the past two centuries. Recent eruptions (1967, 1969, and 1970) and the volcanic unrest episodes that happened in 1992, 1999, and 2014–2015 demonstrate that the occurrence of future volcanic activity is a valid and pressing concern for scientists, technical and logistic personnel, and tourists, that are visiting or working on or near the island. We present a unifying evolutionary model of the magmatic system beneath Deception Island by integrating new petrologic and geochemical results with an exhaustive database of previous studies in the region. Our results reveal the existence of a complex plumbing system composed of several shallow magma chambers (≤10 km depth) fed by magmas raised directly from the mantle, or from a magma accumulation zone located at the crust-mantle boundary (15–20 km depth). Understanding the current state of the island’s magmatic system, and its potential evolution in the future, is fundamental to increase the effectiveness of interpreting monitoring data during volcanic unrest periods and hence, for future eruption forecasting.
Effects of Relative Magnetic Field, Chemical Reaction, Heat Generation and Newtonian Heating on Convection Flow of Casson Fluid over a Moving Vertical Plate Embedded in a Porous Medium
Authors: Khan Dolat , Khan Arshad , Khan Ilyas , Ali Farhad , Karim Faizan ul , Tlili I. 
Published: January 2019

AbstractThe aim of this article is to study the combined effects of heat generation and chemical reaction on magnetohydrodynamic (MHD) natural convection flow over a moving plate embedded in a porous medium. Natural convection is caused due to buoyancy forced which has been induced because of temperature and concentration gradients. The general condition of velocity has been considered on the plate surface with Newtonian heating and constant wall concentration. The effect of thermal radiation is also considered in the energy equation. The main objective here is to study the relative behavior of the magnetic field. That is the magnetic field shows two types of relative behavior. More exactly, when the magnetic field is fixed relative to the fluid (MFFRF) and the magnetic field is fixed relative to the plate (MFFRP). The general exact solution of the problem is determined by the Laplace transform method. Particular solutions for two special cases namely the plate with variable vibration and the plate with sine and cosine oscillations are also determined. Moreover, the solutions when ζ → ∞ for both cases i.e. MFFRF and MFFRP are also obtained as special cases. The velocity profile is presented in the form of mechanical, thermal and concentration components. Velocity obtained for oscillating plate condition is written in terms of steady-state and transient parts. Exact solutions obtained in this paper are interpreted graphically using computational software Mathcad-15 to examine the effects of various pertinent parameters such as Casson fluid parameter, the permeability of porous medium, chemical reaction parameter, heat generation parameter, buoyancy force parameter, magnetic parameter, and radiation parameter. Results for Sherwood number, skin-friction, and Nusselt number are numerically computed and discussed.
Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study
Authors: Mainprize Todd , Lipsman Nir , Huang Yuexi , Meng Ying , Bethune Allison , Ironside Sarah , Heyn Chinthaka , Alkins Ryan , Trudeau Maureen , Sahgal Arjun , Perry James , Hynynen Kullervo 
Published: January 2019

AbstractThe blood-brain barrier (BBB) has long limited therapeutic access to brain tumor and peritumoral tissue. In animals, MR-guided focused ultrasound (MRgFUS) with intravenously injected microbubbles can temporarily and repeatedly disrupt the BBB in a targeted fashion, without open surgery. Our objective is to demonstrate safety and feasibility of MRgFUS BBB opening with systemically administered chemotherapy in patients with glioma in a phase I, single-arm, open-label study. Five patients with previously confirmed or suspected high-grade glioma based on imaging underwent the MRgFUS in conjunction with administration of chemotherapy (n = 1 liposomal doxorubicin, n = 4 temozolomide) one day prior to their scheduled surgical resection. Samples of “sonicated” and “unsonicated” tissue were measured for the chemotherapy by liquid-chromatography-mass spectrometry. Complete follow-up was three months. The procedure was well-tolerated, with no adverse clinical or radiologic events related to the procedure. The BBB within the target volume showed radiographic evidence of opening with an immediate 15–50% increased contrast enhancement on T1-weighted MRI, and resolution approximately 20 hours after. Biochemical analysis of sonicated versus unsonicated tissue suggest chemotherapy delivery is feasible. In this study, we demonstrated transient BBB opening in tumor and peritumor tissue using non-invasive low-intensity MRgFUS with systemically administered chemotherapy was safe and feasible. The characterization of therapeutic delivery and clinical response to this treatment paradigm requires further investigation.
Understanding the oxidation mechanism of methanesulfinic acid by ozone in the atmosphere
Authors: Lv Guochun , Zhang Chenxi , Sun Xiaomin 
Published: January 2019

AbstractMethanesulfinic acid (MSIA) is an important intermediate in the oxidation of dimethyl sulfide (DMS) in the marine boundary layer. The oxidation of MSIA by ozone in the gas phase to form methanesulfonic acid (MSA) was investigated using theoretical calculations in this paper. Three pathways can be found for the reaction of MSIA with ozone. The highest energy barrier is 13.02 kcal mol−1 in the most favorable pathway. By comparing the reaction rate of MSIA + O3 with that of MSIA + OH, it can be concluded that the oxidation of MSIA by O3 to form MSA is of minor significance relative to its oxidation by OH radical in the gas phase. This study can provide some information for the theoretical and experimental studies in the significantly heterogeneous and aqueous-phase oxidation of MSIA by O3.