bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prognostic Prediction Role of Preoperative Serum Albumin Level in Patients with Intahepatic Cholangiocarcinoma Following Hepatectomy
Authors: Shen Junyi , Wen Tianfu , Li Chuan , Yan Lvnan , Li Bo , Yang Jiayin 
Published: April 2018

<b><i>Background:</i></b> There is little information regarding the role of preoperative serum albumin (ALB) in intrahepatic cholangiocarcinoma (ICC) patients who underwent liver resection. <b><i>Methods:</i></b> Clinicopathological characteristics and survival rate of 91 ICC patients who underwent surgery between 2009 and 2013 were included in this study. The optimal cut-off for ALB were determined by plotting the receiver operating characteristics curves of ALB in predicting overall survival (OS) and utilizing the Youden index. Long-term outcome was calculated by Kaplan-meire method. <b><i>Results:</i></b> The pathological characteristics were similar in both groups. The 1- and 3-year disease-free survival (DFS) rates between the high ALB group and the lower ALB group were 62.7 vs. 25.5% and 27.0 vs. 11.1% respectively (<i>p</i> &#x3c; 0.001). The 1- and 3-year OS rates between the high ALB group and the lower ALB group were 78.4 vs. 57.5% and 42.6 vs. 6.7% respectively (<i>p</i> &#x3c; 0.001). The ALB level as continuous variable in multivariate analysis remained a favorable factor for DFS and OS (<i>p</i> &#x3c; 0.05). Furthermore, ALB could distinguish the prognoses in non-cirrhotic patients. Multivariate analysis showed other pathological risk factors like lymph node involvement, positive surgical margin, satellite lesions, and carbohydrate antigen 19-9 were associated with DFS and OS (<i>p</i> &#x3c; 0.05 for all). <b><i>Conclusions:</i></b> A higher preoperative serum ALB level is associated with better long-term survival in ICC patients.
The Use of Low-Calcium Hemodialysis in the Treatment of Hypercalcemic Crisis
Authors: Trabulus Sinan , Oruc Meric , Ozgun Emre , Altiparmak Mehmet Riza , Seyahi Nurhan 
Published: April 2018

<b><i>Background:</i></b> We reviewed the results of low-calcium hemodialysis (LCHD; 1.25 mmol/L) in the treatment of 42 cases admitting with hypercalcemic crisis. <b><i>Methods:</i></b> All patients (≥18 years) who started LCHD due to hypercalcemia between 2002 and 2017 were retrospectively analyzed. Biochemical data were obtained at the beginning of the first hemodialysis and at the end of the last hemodialysis. ­“Refractory” cases were defined as patients having albumin corrected serum total calcium (SCa<sub>total</sub>) levels above 10.2 mg/dL despite of all medical, surgical, and hemodialysis treatments. <b><i>Results:</i></b> By acceptance of 3 cases admitted again over 6 months as new cases, a total of 42 cases (male, 57.1%) with a mean age of 55.9 ± 14.8 years underwent urgent hemodialysis. Most of the patients (82.1%) had malignancies. The mean SCa<sub>total</sub> level at the beginning of hemodialysis sessions was 15.89 ± 2.53 mg/dL. The mean decline of SCa<sub>total</sub> level was 4.63 ± 2.72 mg/dL. Refractory cases received hemodialysis after admission significantly later than improved cases (48 [interquartile ranges (IQR) 24–168] vs. 24 [IQR 12–48] h, <i>p</i> = 0.010). Serum creatinine and SCa<sub>total</sub> levels at the last visit were significantly more in refractory cases than improved cases (1.92 [IQR 0.81–3.41] vs. 1.30 [IQR 0.8–1.7] mg/dL, <i>p</i> = 0.031 and 12.43 ± 2.53 vs. 8.86 ± 0.67 mg/dL, <i>p</i> = 0.000 respectively). Mortality was significantly higher in refractory cases than improved cases (58.8 vs. 10.5%, <i>p</i> = 0.002). Overall mortality rate was 33.3%. <b><i>Conclusion:</i></b> Hypercalcemic crisis is a life-threatening condition and should be managed immediately.
A multicentered pharmacoepidemiological approach to evaluate clinically significant potential drug–drug interactions in medical intensive care settings in Pakistan
Authors: Shakeel Faisal , Khan Jamshaid Ali , Aamir Muhammad , Asim Syed Muhammad , Ullah Irfan 
Published: April 2018

Background: Iatrogenic injuries due to drug–drug interactions are particularly significant in critical care units because of the severely compromised state of the patient. The risk further increases with the use of multiple drugs, increasing age, and stay of the patient. Objective: The aim was to assess potential drug–drug interactions, evaluate clinically significant potential drug–drug interactions and their predictors in medical intensive care units of tertiary hospitals in Pakistan. Methods: Analysis of patient data collected from medical intensive care units of tertiary hospitals in Pakistan were carried out using Micromedex DrugReax. Various statistical tools were applied to identify the significance of associated predictors. Results: In a total of 830 patients, prevalence of potential drug–drug interactions was found to be 39%. These attributed to 190 drug combinations, of which 15.4% were clinically significant. A significant association of potential drug–drug interactions was present with number of prescribed drugs, age, and gender. In terms of clinically significant potential drug–drug interactions, the association was significant with increasing age. Moreover, one-way analysis of variance revealed a significant difference in the means of potential drug–drug interactions among the four hospitals. Conclusion: A prevalence of 39% potential drug–drug interactions was observed in patients of medical intensive care unit, with 22.8% being clinically significant. These attributed to nine drug pairs and could easily be avoided to reduce the risk of adverse effects from potential drug–drug interactions.
DACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis
Authors: Liu Qian , Li Anping , Yu Shengnan , Qin Shuang , Han Na , Pestell Richard G. , Han Xinwei , Wu Kongming 
Published: April 2018

Abstract
Background
C-X-C motif ligand 8 (CXCL8), known as a proinflammatory chemokine, exerts multiple effects on the proliferation, invasion, and migration of tumor cells via the autocrine or paracrine manner. Conversely, the human Dachshund homologue 1 (DACH1) is recognized as a tumor suppressor which retards the progression of various cancers. In prostate cancer, it has been demonstrated that DACH1 was negatively correlated with the expression of CXCL8 and able to antagonize the effects of CXCL8 on cellular migration. Herein, we explored the mechanisms by which DACH1 regulated the CXCL8 in non-small cell lung cancer (NSCLC).

Methods
Public microarray and Kaplan-Meier plotter datasets were analyzed. Blood serum samples from lung adenocarcinoma (ADC) patients were collected for enzyme-linked immunosorbent assay (ELISA) analysis. Immunohistochemical staining was conducted on tissue microarray. Cell lines with stable expression of DACH1 were established, and relative gene expression was measured by Western blot, ELISA, real-time PCR, and human cytokine array. Correspondingly, cell lines transfected with shDACH1 were established, and relative gene expression was measured by real-time PCR and immunofluorescence array. Functional studies were performed by transwell and xenograft mice models. Luciferase reporter gene assay was applied to measure the regulation of DACH1 on CXCL8.

Results
Our study indicated that CXCL8 both at the mRNA and protein level was associated with the high tumor burden of ADC. Correlational analyses in ADC cell lines and ADC tissues showed that DACH1 was inversely correlated with CXCL8. Meanwhile, patients with high DACH1 expression and low CXCL8 expression had prolonged time to death and recurrence. Moreover, we verified the inhibitory effects of DACH1 on CXCL8 both in vitro and in vivo. Mechanism studies proved that DACH1 transcriptionally repressed CXCL8 promoter activity through activator protein-1 (AP-1) and nuclear transcription factor-kappa B (NF-κB) sites.

Conclusions
Our study proved that CXCL8 acted as an unfavorable factor promoting to tumor progression and poor prognosis of ADC, while DACH1 antagonized CXCL8 to provide a favorable survival of ADC patients. Double detection of DACH1 and CXCL8 may provide a precise information for further evaluating the prognosis of ADC patients.
Managing diabetic foot infections: a survey of Australasian infectious diseases clinicians
Authors: Commons Robert J. , Raby Edward , Athan Eugene , Bhally Hasan , Chen Sharon , Guy Stephen , Ingram Paul R. , Lai Katy , Lemoh Chris , Lim Lyn‐Li , Manning Laurens , Miyakis Spiros , O'Reilly Mary , Roberts Adam , Sehu Marjoree , Torda Adrienne , Vicaretti Mauro , Lazzarini Peter A. 
Published: April 2018

AbstractBackgroundDiabetic foot infections (DFI) present a major morbidity, mortality and economic challenge for the tertiary health sector. However, lack of high quality evidence for specific treatment regimens for patients with DFIs may result in inconsistent management. This study aimed to identify DFI caseload proportion and patterns of clinical practice of Infectious Diseases (ID) Physicians and Trainees within Australia and New Zealand.MethodsA cross‐sectional online survey of Australian and New Zealand ID Physicians and Trainees was undertaken, to estimate the overall ID caseload devoted to patients with DFIs and assess clinicians' management practices of patients with DFIs.ResultsApproximately 28% (142/499) of ID Physicians and Trainees from Australia and New Zealand responded to the survey. DFI made up 19.2% of all ID consultations. Involvement in multidisciplinary teams (MDT) was common as 77.5% (93/120) of those responding indicated their patients had access to an inpatient or outpatient MDT. Significant heterogeneity of antimicrobial treatments was reported, with 82 unique treatment regimens used by 102 respondents in one scenario and 76 unique treatment regimens used by 101 respondents in the second scenario. The duration of therapy and the choice of antibiotics for microorganisms isolated from superficial swabs also varied widely.ConclusionsPatients with DFIs represent a significant proportion of an ID clinician's caseload. This should be reflected in the ID training program. Large heterogeneity in practice between clinicians reflects a lack of evidence from well‐designed clinical trials for patients with DFI and highlights the need for management guidelines informed by future trials.
Endoscopic management of maxillary sinus inverted papilloma attachment sites to minimize disease recurrence
Authors: Wu Vincent , Siu Jennifer , Yip Jonathan , Lee John M. 
Published: April 2018

Background Inverted papillomas (IPs) are benign neoplasms, most commonly arising from the mucosal lining of the maxillary sinus. IPs can have single or multifocal sites of attachment. Although pedicle location is an important factor to consider in surgical planning, it is less clear whether the location or number of IP attachment sites hold any prognostic value. Herein, we aimed to determine the prognostic significance of the number and location of attachment sites of IPs originating from the maxillary sinus when managed by a pure endoscopic approach. Methods This was a single-center, single-surgeon retrospective chart review. Patients with maxillary sinus IPs who were managed by endoscopic approaches only, from January 1, 2010 to June 30, 2016, were identified. Demographic data, operative technique, number and location of IP attachment sites, follow-up duration, recurrence, and presence of malignant transformation were captured. Results Twenty-eight maxillary IP patients (61% males) were included, with a mean age of 54.9 (standard deviation (SD): 16.5) years. Approximately 36% of patients were referred from other institutions for management of recurrent IPs after failing previous surgical treatment. All patients were managed with an endoscopic approach, and all required an endoscopic medial maxillectomy to facilitate access to the maxillary sinus. At a mean follow-up of 31.1 (SD: 22.6) months, there were no recurrences identified. IPs with single (46%) and multifocal (54%) attachments were predominately to the medial and lateral walls. Maxillary IPs with multifocal attachments most frequently involved 2-3 walls of the sinus. Osteitis (36%) was commonly seen. Conclusion IPs originating from the maxillary sinus frequently had multifocal attachments, but this did not impact disease recurrence. Despite the surgical challenges of accessing all of the maxillary sinus walls, IPs originating from the maxillary sinus can be effectively managed via a pure endoscopic approach.
The semiotic sense of context vs the material sense of context
Authors: Bowcher Wendy L. 
Published: April 2018

AbstractThis paper investigates the relationship between culture and language through analyzing material and semiotic features in a context of language-in-use. The paper first discusses what is meant by ‘material’ and ‘semiotic’ context from an SFL perspective. It then investigates the way in which these two ‘senses’ of context may converge within a specific instance, affecting interaction in a subtle way and together construing a cultural phenomenon.
System for automated wear-resistance technological control of machinery at cutting
Authors: Суслов Анатолий , Suslov Anatoliy , Петрешин Дмитрий , Petreshin Dmitriy , Федонин Олег , Fedonin Oleg , Медведев Дмитрий , Medvedev Dmitriy 
Published: April 2018

The peculiarities in the realization of algorithmic and mathematical software for technological control of machinery wear during machine parts cutting are considered. At the same time the adaptive system of quality control of parts surfaces machining on NC machines is used. This system allows decreasing cost price of manufacturing parts and ensuring their required life.
The system developed allows choosing a method and modes of part surface finish cutting ensuring a value of its wear intensity at operation not exceeding permissible one with minimum technological cost price.
It allows carrying out finish cutting a part surface with the optimum method and in optimum modes on a machine, possibly, equipped with NC systems with the adaptive wear-resistance control of the part under machining.
„Zobaczyć oryginał” – rola wizualizacji w doskonaleniu umiejętności przekładu tekstów literackich i nieliterackich
Authors: Guttfeld Dorota , Linke‑Ratuszny Monia 
Published: April 2018

To see the source text. The role of visual imagination in building competence for literary and non‑literary translation
The paper discusses the importance of spatial and visual imagination in the process of producing translations. Although visual aspects are usually associated with literary imaging, and hence teaching literary translation, they prove crucial in non‑literary translation as well, where the stress is traditionally put on terminological accuracy and research skills. Exercises requiring students to understand spatial relationships and visualize situations or objects illustrate the use of the skill. Pointing to analogies between literary and non‑literary translation, the paper encourages the integration of topics and task varieties between classes devoted to these two types of texts.
Effects of Dye Surface Concentration on the Molecular Aggregation of Xanthene Dye in Colloidal Dispersions of Montmorillonite
Authors: Baranyaiová Tímea , Bujdák Juraj 
Published: April 2018

AbstractThe molecular aggregation of organic dyes onto clay mineral particles is a very complex phenomenon including dye adsorption, the migration of dye molecules, rearrangement of initially formed aggregates, etc. Some details of this complex process are not yet fully understood. The objective of the present study was to understand the influence of dye surface concentration on the dynamic processes in dye molecular aggregation. A stopped-flow rapid mixing device was used for accurate measurements of the molecular aggregation of the cationic dye rhodamine 123 (R123) in montmorillonite (MntK) colloidal dispersions. The influence of dye surface concentration, which was changed by altering the ratio of the amount of R123 to the mass of MntK (nR123/mMntK), was examined in detail. Chemometric analysis was used to reconstruct the spectral matrix to obtain linearly uncorrelated spectral profiles of the major components and their concentrations at the respective reaction times. The conversion of isolated R123 cations into oblique J-aggregates (head-to-tail molecular assemblies) was observed over time and the existence of a J-dimers intermediate was hypothesized. The reaction kinetics followed a biphasic exponential function. An unexpected effect of dye surface concentration on R123 aggregation was observed: the initial formation of the molecular aggregates increased significantly with dye surface concentration, but an inverse trend was observed after longer reaction times. While dye aggregates were formed slowly at low dye loadings, systems with high R123/MntK ratios (nR123/mMntK) reached spectral stability after the first few seconds of the reaction. After longer reaction times, the greatest degree of dye aggregation was achieved in the dispersion of the lowest dye loading. Such a phenomenon is described for the first time. The results presented here are important for understanding the complex processes occurring in systems based on organic cations and clay minerals, and should be considered in the development of functional hybrid materials of dyes and nanoparticles with a layered structure.
Reading in Children With Fragile X Syndrome: Phonological Awareness and Feasibility of Intervention
Authors: Adlof Suzanne M. , Klusek Jessica , Hoffmann Anne , Chitwood Kerrie L. , Brazendale Allison , Riley Karen , Abbeduto Leonard J. , Roberts Jane E. 
Published: April 2018

AbstractIndividuals with fragile X syndrome (FXS) present with significant deficits in reading skills, but scant research exists to understand the characteristics of the reading delays or best practices for reading instruction with this population. Study 1 examined the relationship between phonological awareness and reading skills in individuals with FXS. Study 2 evaluated the feasibility of a web-based reading intervention, which incorporated phonological awareness and phonics instruction but was originally developed for mainstream students, for children with FXS. Results suggest that phonological awareness and reading skills are correlated in this population, and that instruction targeting phonological awareness and phonics should not be ruled out for individuals with FXS. Further studies are needed to examine their potential effects.
Are Busy Directors Harmful or Helpful? Evidence from the Great Recession
Authors: Withisuphakorn Pradit , Jiraporn Pornsit 
Published: April 2018

Abstract
We contribute to the debate on the costs and benefits of busy directors by investigating the effect of busy directors on firm value during a stressful time, i. e. during the Great Recession. Our results show that busy directors improve firm value significantly during the financial crisis. In particular, a rise in directors’ busyness by one standard deviation results in an improvement in Tobin’s q by 6.41 %. Directors with multiple board seats appear to help firms navigate the crisis more successfully, supporting the notion that multiple board seats signal higher quality. Outside the crisis period, however, we find that busy directors reduce firm value, consistent with many prior studies. Our results are crucial as they show that governance mechanisms function differently during stressful times than they do during normal times. Firms should exercise great caution before imposing limits on outside board seats on their directors.
An evidence- and risk-based approach to a harmonized laboratory alert list in Australia and New Zealand
Authors: Campbell Craig A. , Lam Que , Horvath Andrea R. 
Published: April 2018

Abstract
Individual laboratories are required to compose an alert list for identifying critical and significant risk results. The high-risk result working party of the Royal College of Pathologists of Australasia (RCPA) and the Australasian Association of Clinical Biochemists (AACB) has developed a risk-based approach for a harmonized alert list for laboratories throughout Australia and New Zealand. The six-step process for alert threshold identification and assessment involves reviewing the literature, rating the available evidence, performing a risk analysis, assessing method transferability, considering workload implications and seeking endorsement from stakeholders. To demonstrate this approach, a worked example for deciding the upper alert threshold for potassium is described. The findings of the worked example are for infants aged 0–6 months, a recommended upper potassium alert threshold of >7.0 mmol/L in serum and >6.5 mmol/L in plasma, and for individuals older than 6 months, a threshold of >6.2 mmol/L in both serum and plasma. Limitations in defining alert thresholds include the lack of well-designed studies that measure the relationship between high-risk results and patient outcomes or the benefits of treatment to prevent harm, and the existence of a wide range of clinical practice guidelines with conflicting decision points at which treatment is required. The risk-based approach described presents a transparent, evidence- and consensus-based methodology that can be used by any laboratory when designing an alert list for local use. The RCPA-AACB harmonized alert list serves as a starter set for further local adaptation or adoption after consultation with clinical users.
‘Hardcastle Hollows’ in loess landforms: Closed depressions in aeolian landscapes – in a geoheritage context
Authors: Fagg Roger , Smalley Ian 
Published: April 2018

AbstractLoess landscapes sometimes contain isolated depressed areas, which often appear as lakes. The outline shape (and distribution) of these depressions could be controlled by random processes, particularly if the depressions are caused by loess hydroconsolidation and ground subsidence. By applying the Zingg system of shape classification it is possible to propose a mean random shape for the closed depressions. A Zingg rectangle with a side ratio of about 2:1 is produced by a very simple Monte Carlo method, which had been used previously to calculate the mean random shape of a loess particle. The Zingg rectangle indicates the basic shape of the mean closed depression. A simple four stage process for the formation of the depressions is proposed. They might be called ‘Hardcastle Hollows’ in honour of John Hardcastle who first reported them, in New Zealand. Studies on Ukrainian deposits suggest that there might be some stratigraphic value in the observation of closed depressions; they are often not superimposed in successive depositions of loess. Hydroconsolidation is important in landscape processes. The hollows provide interesting habitats and enlarge the ecological interest of loess deposits; the geoheritage scene is enhanced.
Upper Bounds for the Conversion Efficiency of Diluted Blackbody Radiation Energy into Work
Authors: Badescu Viorel 
Published: April 2018

Abstract
A new formula has been proposed for the Landsberg–Tonge function

χ
(
ε
)

\chi (\varepsilon )

entering the entropy density flux of the diluted blackbody radiation of dilution factor ε. Two models have been proposed for the conversion of diluted blackbody radiation energy into work. The Carnot and Petela–Landsberg–Press relationships do not provide accurate upper bounds for the real conversion efficiency and in some cases they wrongly estimate positive output work when the converter of radiation energy into work does not operate. Four upper bounds for the conversion efficiency have been derived. The most accurate upper bound efficiency requires the numerical solution of an algebraic equation for the optimum absorber temperature while the second best upper bound efficiency has the advantage that it is a simple analytical formula.