bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mind-Wandering in People with Hippocampal Damage
Authors: McCormick Cornelia , Rosenthal Clive R. , Miller Thomas D. , Maguire Eleanor A. 
Published: February 2018

Subjective inner experiences, such as mind-wandering, represent the fundaments of human cognition. Although the precise function of mind-wandering is still debated, it is increasingly acknowledged to have influence across cognition on processes such as future planning, creative thinking, and problem-solving and even on depressive rumination and other mental health disorders. Recently, there has been important progress in characterizing mind-wandering and identifying the associated neural networks. Two prominent features of mind-wandering are mental time travel and visuospatial imagery, which are often linked with the hippocampus. People with selective bilateral hippocampal damage cannot vividly recall events from their past, envision their future, or imagine fictitious scenes. This raises the question of whether the hippocampus plays a causal role in mind-wandering and, if so, in what way. Leveraging a unique opportunity to shadow people (all males) with bilateral hippocampal damage for several days, we examined, for the first time, what they thought about spontaneously, without direct task demands. We found that they engaged in as much mind-wandering as control participants. However, whereas controls thought about the past, present, and future, imagining vivid visual scenes, hippocampal damage resulted in thoughts primarily about the present comprising verbally mediated semantic knowledge. These findings expose the hippocampus as a key pillar in the neural architecture of mind-wandering and also reveal its impact beyond episodic memory, placing it at the heart of our mental life.SIGNIFICANCE STATEMENTHumans tend to mind-wander ∼30–50% of their waking time. Two prominent features of this pervasive form of thought are mental time travel and visuospatial imagery, which are often associated with the hippocampus. To examine whether the hippocampus plays a causal role in mind-wandering, we examined the frequency and phenomenology of mind-wandering in patients with selective bilateral hippocampal damage. We found that they engaged in as much mind-wandering as controls. However, hippocampal damage changed the form and content of mind-wandering from flexible, episodic, and scene based to abstract, semanticized, and verbal. These findings expose the hippocampus as a key pillar in the neural architecture of mind-wandering and reveal its impact beyond episodic memory, placing it at the heart of our mental life.
Altered Signaling in the Descending Pain-modulatory System after Short-Term Infusion of the μ-Opioid Agonist Remifentanil
Authors: Sprenger Christian , Eichler Iris-Carola , Eichler Lars , Zöllner Christian , Büchel Christian 
Published: February 2018

μ-Opioid receptor agonists are widely used within the contemporary treatment of pain, but abrupt opioid suspension, even after short-term infusion, can paradoxically increase the sensitivity to noxious stimuli, a phenomenon that has been, for example, reported after application of the fast-acting μ-opioid receptor agonist remifentanil. To investigate the mechanisms underlying the effects of discontinuation of remifentanil application on pain processing in the human CNS, we analyzed neuronal responses to thermal stimuli before and after a short-term infusion of remifentanil (30 min 0.1 μg/kg body weight/min) compared with control in the brain, brainstem, and spinal cord in drug-naive male volunteers using fMRI. Subsequent to remifentanil suspension, we observed reduced heat pain thresholds and increased neuronal responses in pain-encoding as well as in key regions of the descending pain-modulatory system, such as the periaqueductal gray matter, the nucleus cuneiformis, and the rostral ventromedial medulla. Moreover, the spinal pain-related multivoxel activity pattern showed an opioid-specific change after drug suspension. Importantly, remifentanil suspension increased the functional coupling between the nucleus cuneiformis and the rostral anterior cingulate cortex, and the coupling strength between the rostral anterior cingulate cortex and the nucleus cuneiformis correlated negatively with the individual pain threshold after opioid suspension. These findings demonstrate that, already subsequent to a short-term infusion of the μ-opioid receptor agonist remifentanil, signaling in the descending pain-modulatory system is fundamentally altered and that these changes are directly related to the behavioral sensitivity to pain.SIGNIFICANCE STATEMENTOpioids are widely used in modern medicine, but, in addition to their known side effects, it is increasingly recognized that opioids can also increase sensitivity to pain subsequent to their use. Using the fast-acting μ-opioid receptor agonist remifentanil and fMRI in healthy male volunteers, this study demonstrates how signaling changes occur along the entire descending pain-modulatory pathway after opioid discontinuation and how these alterations are closely linked to increased behavioral pain sensitivity. Particularly by revealing modified responses in pain-modulatory brainstem regions that have been previously demonstrated to be causally involved in acute opioid withdrawal effects in rodents, the data provide a plausible neuronal mechanism by which the increased sensitivity to pain after opioid suspension is mediated in humans.
Emotional Freedom Techniques for Reducing Anxiety and Cortisol Level in Pregnant Adolescent Primiparous
Authors: Mardjan Mardjan , Prabandari Yayi Suryo , Hakimi Mohammad , Marchira Carla R. 
Published: February 2018

ABSTRACT
Anxiety during pregnancy in primiparous mother will be a hard burden because of the immature both psycologic and reproductive organs which can increase the risk of maternal mortality, infant mortality, prolonged childbirth, LBW, postpartum depression, etc. An effort to minimize the anxiety is the implementation of EFT (Emotional Freedom Techniques) during the third trimester.
This research purposed to assess the effectiveness of EFT to decrease anxiety in facing childbirth. This research used the quasi-experimental pre-test and post-test method of treatment and control. The treatment was done during the third trimester, started and followed for 3 months ie month 7th, 8th, 9th. The EFT was implemented every month then continued independently by the mother, until before childbirth process. The research instrument used TMAS (Taylor Manifest Anxiety Scale) and cortisol blood test. The subjects were 38 respondents consisted of 19 interventions and 19 controls.
Result with paired t-test, TMAS1,2,3, each stage got significant difference, pre and post blood cortisol level p = 0.0001. Linear regression analysis on TMAS p = 0.001 and R² = 0.57, whereas blood cortisol level p = 0.004 and R² = 0.43. This analysis proved EFT contributed significantly 57% to lower anxiety levels and 43% to lower blood cortisol level, indirectly affected the readiness to face childbirth process.

ABSTRAK
Kecemasan selama kehamilan pada ibu primipara akan memberatkan kondisi bayi dalam kandungan karena secara psikologis kejiwaannya belum siap dan organ reproduksi belum sempurna yang dapat meningkatkan risiko dalam persalinan dan merupakan salah satu faktor penyebab kematian ibu, bayi, partus lama, BBLR, depresi postpartum, dll. Upaya meminimalisasi kecemasan ini dilakukan dengan metode EFT (Emotional Freedom Techniques) selama trimester ketiga.
Tujuan penelitian untuk mengetahui efektivitas EFT terhadap penurunan kecemasan dalam menghadapi persalinan. Penelitian ini menggunakan metode quasi eksperimen pre test dan post terhadap perlakuan dan kontrol. Perlakuan dilakukan selama trimester III, dimulai dan diikuti selama 3 bulan yaitu bulan ke-7, 8, 9. EFT dilakukan setiap bulan dan dilanjutkan secara mandiri oleh ibu, sampai menjelang persalinan. Instrumen penelitian menggunakan TMAS (Taylor Manifest Anexity Scale) dan pemeriksaan darah kortisol. Subyek penelitian 38 responden, terdiri atas 19 intervensi dan 19 kontrol.
Hasil penelitian dengan uji paired t-test, TMAS1,2,3, setiap tahapannya didapatkan perbedaan bermakna yaitu kortisol darah pre dan post p=0,0001, analisa regresi liniear TMAS p = 0,001, dan R² = 0,57; serta kortisol darah p=0,004 dan R²=0,43. Analisa ini membuktikan EFT berkontribusi 57% menurunkan tingkat kecemasan dan 43% dalam menurunkan kortisol darah secara signifikan yang secara tidak langsung berpengaruh terhadap kesiapan menghadapi persalinan.
Association of fetuin-A with incident type 2 diabetes: results from the MONICA/KORA Augsburg study and a systematic meta-analysis
Authors: Sujana Chaterina , Huth Cornelia , Zierer Astrid , Meesters Sophie , Sudduth-Klinger Julie , Koenig Wolfgang , Herder Christian , Peters Annette , Thorand Barbara 
Published: February 2018

Objective
We investigated the association of circulating fetuin-A with incident T2D particularly examining potential sex differences. Additionally, we determined whether putative associations were independent of subclinical inflammation, adiponectin and liver fat content.

Design
Case-cohort study plus systematic meta-analysis.

Methods
We investigated the association between baseline fetuin-A levels and incident T2D in the MONICA/KORA Augsburg study using Cox proportional hazards analyses. Furthermore, we conducted a systematic review within PubMed and EMBASE and pooled association estimates of eligible studies with the MONICA/KORA Augsburg data using a DerSimonian-Laird random effects model.

Results
Within MONICA/KORA Augsburg, 930 participants developed incident T2D (median follow-up: 14 years). We observed a significant association between fetuin-A and T2D risk after multivariable adjustment including C-reactive protein and adiponectin. The strength of the association was similar in males and females (P value for sex interaction >0.55). Seven eligible published studies were identified in addition to the MONICA/KORA Augsburg study for the meta-analysis. The pooled hazard ratio (95% CI) for incident T2D per 1 standard deviation (s.d.) increment of fetuin-A was 1.24 (1.14–1.34) for the multivariable adjusted model. Our sex-stratified meta-analysis yielded relative risk estimates per 1 s.d. of 1.19 (1.04–1.38) in males and 1.29 (1.15–1.46) in females. Further individual adjustment for subclinical inflammation, adiponectin and liver fat content had almost no impact on the strength of the association.

Conclusions
Higher fetuin-A levels are associated with incident T2D in both males and females independently of subclinical inflammation, adiponectin and liver fat content.
Solutions of stationary Kirchhoff equations involving nonlocal operators with critical nonlinearity in RN
Authors: Piao Ziwei , Zhou Chenxing , Liang Sihua 
Published: February 2018

In this paper, we consider the existence and multiplicity of solutions for fractional Schrödinger equations with critical nonlinearity in RN. We use the fractional version of Lions' second concentration-compactness principle and concentration-compactness principle at infinity to prove that (PSc) condition holds locally. Under suitable assumptions, we prove that it has at least one solution and, for any m ∈ N, it has at least m pairs of solutions. Moreover, these solutions can converge to zero in some Sobolev space as ε → 0.
Fixed point results in b-metric spaces using families of control functions and their application to dynamic programming
Authors: Kadelburg Zoran , Nashine Hemant Kumar Kumar , Padhan Saroj Kumar Kumar , Rao G.V.V. J Jagannadha Jagannadha 
Published: February 2018

We obtain some fixed point theorems for mappings acting in b-metric spaces. The results extend those obtained in [R.P. Agarwal, E. Karapınar, A.F. Roldán-López-de-Hierro, On an extension of contractivity conditions via auxiliary functions, Fixed Point Theory Appl., 2015:104, 20015] using families of control functions, here also through conditions that involve α-admissibility of type S. We furnish an illustrative example to demonstrate the validity of the hypotheses and the degree of usefulness of our results. As an application, the existence of solution for functional equations arising in dynamic programming is discussed, followed by suitable examples.
Impulsive coupled systems with generalized jump conditions
Authors: Minhós Feliz , De Sousa Robert 
Published: February 2018

This work considers a second order impulsive coupled system with full nonlinearities, generalized impulse functions and mixed boundary conditions. This is the first time where such coupled systems are considered with nonlinearities with dependence on both unknown functions and their derivatives, together impulsive functions given by more general framework allowing jumps on the both functions and both derivatives.The arguments apply the fixed point theory, Green's functions echnique, L1-Carathéodory functions theory and Schauder's fixed point theorem.An application to the transverse vibration system of elastically coupled double-string is presented in the last section.
Maximum likelihood estimation for Gaussian process with nonlinear drift
Authors: Mishura Yuliya , Ralchenko Kostiantyn , Shklyar Sergiy 
Published: February 2018

We investigate the regression model Xt = θG(t) + Bt, where θ is an unknown parameter, G is a known nonrandom function, and B is a centered Gaussian process. We construct the maximum likelihood estimators of the drift parameter θ based on discrete and continuous observations of the process X and prove their strong consistency. The results obtained generalize the paper [Yu. Mishura, K. Ralchenko, S. Shklyar, Maximum likelihood drift estimation for Gaussian process with stationary increments, Austrian J. Stat., 46(3–4): 67–78, 2017] in two directions: the drift may be nonlinear, and the noise may have nonstationary increments. As an example, the model with subfractional Brownian motion is considered.
Influenza-Associated Pediatric Deaths in the United States, 2010–2016
Authors: Shang Mei , Blanton Lenee , Brammer Lynnette , Olsen Sonja J. , Fry Alicia M. 
Published: February 2018

BACKGROUND:
Influenza-associated pediatric deaths became a notifiable condition in the United States in 2004.

METHODS:
We analyzed deaths in children aged &lt;18 years with laboratory-confirmed influenza virus infection reported to the Centers for Disease Control and Prevention during the 2010–2011 to 2015–2016 influenza seasons. Data were collected with a standard case report form that included demographics, medical conditions, and clinical diagnoses.

RESULTS:
Overall, 675 deaths were reported. The median age was 6 years (interquartile range: 2–12). The average annual incidence was 0.15 per 100 000 children (95% confidence interval: 0.14–0.16) and was highest among children aged &lt;6 months (incidence: 0.66; 95% confidence interval: 0.53–0.82), followed by children aged 6–23 months (incidence: 0.33; 95% confidence interval: 0.27–0.39). Only 31% (n = 149 of 477) of children aged ≥6 months had received any influenza vaccination. Overall, 65% (n = 410 of 628) of children died within 7 days after symptom onset. Half of the children (n = 327 of 654) had no preexisting medical conditions. Compared with children with preexisting medical conditions, children with none were younger (median: 5 vs 8 years old), less vaccinated (27% vs 36%), more likely to die before hospital admission (77% vs 48%), and had a shorter illness duration (4 vs 7 days; P &lt; .05 for all).

CONCLUSIONS:
Each year, influenza-associated pediatric deaths are reported. Young children have the highest death rates, especially infants aged &lt;6 months. Increasing vaccination among children, pregnant women, and caregivers of infants may reduce influenza-associated pediatric deaths.
Ecologo-faunistic review of lamellicorn beetles (Coleoptera, Scarabaeoidea) of urbocenosis of Kharkov city (Ukraine)
Authors: Putchkov O. V. , Markina T. Y. , Komaromi N. 
Published: February 2018

This article presents a general overview of the superfamily Scarabaeoidea in five parks of Kharkov city and some adjacent agrocenosises. The species composition includes 32 species from four families of Scarabaeoidea. The Scarabaeidae family dominated in biodiversity and abundance (26 species from 16 genera). Six species (Dorcus parallelopipedus, Platyderes caraboides, Anoplotrupes stercorosus, Aphodius melanostictus, Pleurophorus caesus and Onthophagus coenobita) were sporadically registered as common, but in separate urban cenosises the number of species did not exceed one or three. The species composition and abundance of lamellicorn beetles was higher in large parks with only slight recreational disturbance. Here from 13 to 20 species were registered. On lawns in the center and in other districts of the city Scarabaeoidea species met very rarely. In the agrocenosises on the outskirts of Kharkov city – 16 species are noted, almost half of which were registered as common. The faunistic similarity of different urban cenosises was at low to medium levels (an average 0.20–0.47). These indices were slightly higher (0.38–0.67) for areas with lower recreational pressure. The indices of faunal similarity of separate parks and agrocenoses were lower (0.18–0.56, but on average – 0.33). At the level of common species, there was no faunistic similarity. The significance of such differences was due to both the low number of most Lamellicorn species and some of their ecological characteristics. The main differences were observed in the ratio of trophic groups and features of the spatial distribution of the dominant species. Smaller differences were observed on biotopic characteristic of most species. There were no differences in the hygropreference of the scarabeid species. In the parks herpetobiont saprophagous species dominated (mainly coprophagous and dendrophagous). In the agrocenoses, dendrochordobiontic phytophagous species predominated. The peculiarities of the ratio of different ecological groups of Scarabaeoidea in urban and agrocenosises are discussed.
Environmental evaluation of suitability of recultivated land in a manganese quarry for the existence of soil biota
Authors: Loza I. М. , Chiorna V. I. 
Published: February 2018

The challenge of degradation of natural ecosystems because of human activity is considered by the world community to be the most serious problems facing mankind. As a result of mineral extraction, man-made landscapes and environmentally ruined areas replace natural habitats and agroecosystems; a whole spectrum of man-made processes are typical for such landscapes, which leads to a decrease in species richness and biological diversity within such areas. Degraded territories formed in the process of coal mining are often partially restored through remediation measures. During the implementation of the technical stage of remediation, substrates with different potential fertility having different environmental properties and quality are used. However, in quality assessment of remediated soils insufficient attention is paid to restoration of the environmental properties of the soils, namely their suitability for the existence of soil biota, which ensures the soil’s sustainability and vitality. The main indicators determining the productivity of remediated lands and the degree of their suitability for the existence of soil biota are values of actual acidity and degree of salinity. An assessment of the quality of reclaimed lands of the Ordzhonikidzevsky ore mining and processing enterprise was carried out on the example of the Zaporizhsky open-cast mine with the aim of assessing the possibility of their economic use and suitability for the existence of soil biota , as well as to make recommendations for further rational use. It was found that main characteristics of the study area (capacity of bulk humic layer, content of humus in the bulk layer, content of physical clay in the bulk humic layer and in the subsoil, average soil density in the meter bulk layer, salinity of the bulk humic layer and subsoil, composition and properties of subsoil), of the Zaporizhzhya quarry's reclamation is suitable for the further settlement and successful existence of the soil biota. It is concluded that as a result of the technical stage of reclamation, an artificial reclaimed soil was obtained, which according to its characteristics is similar to the primary zonal soils that were located in this area prior to mining; the recultivated soil has somewhat lower fertility and greater salinity at the lower horizons, but is capable of performing ecological functions and can not only be used for economic purposes, but also perform ecological functions, serving as an environment for the existence of soil biota.
Ethnobotanical and ecological study of Punica granatum in Dir district, Khyber Pakhtunkhwa, Pakistan
Authors: Ali K. , Khan S. , Khan N. , Khan W. , Rahman I. U. , Ullah F. , Ali K. , Nisar M. 
Published: February 2018

Punica granatum L. (wild) belongs to family Punicaceae, a woody plant, predominantly found on calcareous and alkaline soils. The species is extensively utilized as food and firewood and for the extraction of various chemicals due to its therapeutic properties. To understand the ethno-botanical and ecological status of the species on a regional scale, a questionnaire survey was conducted in the Dir (L) area using close and open-ended questionnaires. Data collected from 124 respondents were analysed quantitatively using statistical analysis to calculate indices like Relative Frequency of Citation (RFC), Use value (UV) and multivariate analysis. GPS data used for the presence data of the plants were used to develop GIS thematic maps. Geo-referenced data on P. granatum was collected from the study area, using GPS. Results suggest that the plant is mostly used as a remedy for dry cough, as an astringent, people used powder form of fruit peelings. It was documented in the present investigation that P. granatum is mainly eradicated due to its extensive use as firewood. The study also evaluated on the major aspect of how the P. granatum can be conserved naturally. It was found out that the plant is conserved in areas inaccessible to humans. The status of the vegetation community around this plant was also explored, it is found out that specific shrub and tree communities were major flora growing in proximity to P. granatum. The finding of this survey has concluded that wild P. granatum is an endangered species due to its extensive and uncontrollable use for firewood, curing diseases and its economic potential. These findings could be exploited to take necessary steps for the conservation of this species.