bluuebunny/crossref_metadata_2025_split huggingface dataset:
Portuguese Observational Study of Ischaemic Stroke in Patients Medicated with Non-Vitamin K Antagonist Oral Anticoagulants
Authors: Beato-Coelho José , Marto João Pedro , Alves José Nuno , Marques-Matos Cláudia , Calado Sofia , Araújo José , Cunha Luís , Pinho João , Azevedo Elsa , Viana-Baptista Miguel , Sargento-Freitas João 
Published: February 2018

<b><i>Introduction:</i></b> Clinical trials and subsequent meta-analyses showed advantages of non-vitamin K antagonists oral anticoagulants (NOACs) over vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation. The impact of preadmission anticoagulation in acute ischaemic stroke (AIS) has not been established. <b><i>Objective:</i></b> To compare functional outcome of patients with AIS with preadmission NOACs vs. VKAs. <b><i>Methods:</i></b> A retrospective analysis was conducted on consecutive AIS patients under oral anticoagulation (VKAs or NOACs) admitted in 4 Portuguese hospitals within a period of 30 months. Two primary outcomes were defined and compared between VKA and NOAC groups: symptomatic intracerebral hemorrhage transformation (sICH) and modified Rankin Scale (mRS) at 3 months. <b><i>Results:</i></b> Four hundred sixty-nine patients were included, of whom 332 (70.8%) were treated with VKA and 137 (29.2%) with NOAC. Patients’ median age was 78.0 and 234 (49.9%) were male. NOAC-treated patients had a higher median CHA<sub>2</sub>DS<sub>2</sub>-VASc score than those under VKA (5.0 vs. 4.0, <i>p</i> = 0.023). The two primary outcomes showed no statistical differences between the VKAs’ group and the NOACs’ group (sICH: 5.4 vs. 5.4% [<i>p</i> = 0.911]; mRS at 3 months: 3.0 vs. 3.0 [<i>p</i> = 0.646], respectively). <b><i>Conclusion:</i></b> Preadmission anticoagulation with NOACs in AIS has a functional impact similar to that of VKAs.
B1a Lymphocytes (CD19+CD5+) Deficiency in Patients with Crohn’s Disease and Its Relation with Disease Severity
Authors: Gil-Borras Rafael , García-Ballesteros Carlos , Benet-Campos Carmen , Catalán-Serra Ignacio , López-Chuliá Francisca , Cuéllar Carmen , Andreu-Ballester Juan Carlos 
Published: February 2018

<b><i>Background/Aims:</i></b> B1a cells (CD19+CD5+) are considered elements of the innate immune system. The aim of this study was to evaluate the frequency of B1a cells in the peripheral blood of patients with Crohn’s disease (CD) and its relation with disease severity. <b><i>Methods:</i></b> In this prospective study, a total of 128 subjects (64 CD patients and 64 healthy controls) were studied. B1a cells in peripheral blood, CD Activity Index, and Simple Endoscopic Score of B1a cells were studied. <b><i>Results:</i></b> A significant decrease of B1a cells in peripheral blood was observed in patients with CD versus controls (<i>p</i> = 0.002), especially in perforating or penetrating patterns (<i>p</i> = 0.017). A lower frequency of B1a cells is related to increased endoscopic severity (Spearman’s Rho: –0.559, <i>p</i> = 0.004). The mean frequency of B1a cells in patients with pre- and post-study surgery was significantly lower than that in patients who did not undergo surgery (<i>p</i> = 0.050 and <i>p</i> = 0.026, respectively). <b><i>Conclusions:</i></b> The B1a cell count in peripheral blood is lower in CD patients. This decrease is directly related to the severity of the disease (penetrating or perforating, Simple Endoscopy Score and surgery complication). These results pointed to the fact that B1a cells play an important role in immune protection in CD.
Postoperative Liver Failure Criteria for Predicting Mortality after Major Hepatectomy with Extrahepatic Bile Duct Resection
Authors: Kawamura Takeshi , Noji Takehiro , Okamura Keisuke , Tanaka Kimitaka , Nakanishi Yoshitsugu , Asano Toshimichi , Ebihara Yuma , Kurashima Yo , Nakamura Toru , Murakami Soichi , Tsuchikawa Takahiro , Shichinohe Toshiaki , Hirano Satoshi 
Published: February 2018

<b><i>Background:</i></b> Post-hepatectomy liver failure (PHLF) is a serious complication after major hepatectomy with extrahepatic bile duct resection (Hx with EBDR) that may cause severe morbidity and even death. The purpose of this study was to compare several criteria systems as predictors of PHLF-related mortality following Hx with EBDR for perihilar cholangiocarcinoma (PHCC). <b><i>Methods:</i></b> The study cohort consisted of 222 patients who underwent Hx with EBDR for PHCC. We compared several criteria systems, including previously established criteria (the International Study Group of Liver Surgery (ISGLS) criterion; and the “50-50” criterion), and our institution’s novel systems “Max T-Bili” defined as total bilirubin (T-Bili) &#x3e;7.3 mg/dL during post-operative days (POD) 1–7, and the “3-4-50” criterion, defined as total bilirubin &#x3e;4 mg/dL and prothrombin time &#x3c;50% on POD #3. <b><i>Results:</i></b> Thirteen patients (5.8%) died from PHLF-related causes. The 3-4-50 criterion showed high positive predictive values (39.1%), the 3-4-50, Max T-Bili, and 50-50 criterion showed high accuracies (91.7, 86.9, and 90.5%, respectively) and varying sensitivities (69.2, 69.2, and 38.5% respectively). <b><i>Conclusions:</i></b> The 3-4-50, Max T-Bili, and 50-50 criterion were all useful for predicting PHLF-related mortality after Hx with EBDR for PHCC.
РОЛЬ СТАРШОЇ МЕДСЕСТРИ В ОРГАНІЗАЦІЇ ДІЯЛЬНОСТІ СЕСТРИНСЬКОГО ПЕРСОНАЛУ
Authors: Andrievska O. V. , Krynytska I. Ya. 
Published: February 2018

У статті викладено сучасні дані щодо цінностей медичної сестри-керівника, її управлінських компетентностей, лідерських якостей, комунікативних здібностей.
Deletion of BMAL1 in Smooth Muscle Cells Protects Mice From Abdominal Aortic Aneurysms
Authors: Lutshumba Jenny , Liu Shu , Zhong Yu , Hou Tianfei , Daugherty Alan , Lu Hong , Guo Zhenheng , Gong Ming C. 
Published: February 2018

Objective—
Abdominal aortic aneurysm (AAA) has high mortality rate when ruptured, but currently, there is no proven pharmacological therapy for AAA because of our poor understanding of its pathogenesis. The current study explored a novel role of smooth muscle cell (SMC) BMAL1 (brain and muscle Arnt-like protein-1)—a transcription factor known to regulate circadian rhythm—in AAA development.

Approach and Results—

SMC-selective deletion of BMAL1 potently protected mice from AAA induced by (1) MR (mineralocorticoid receptor) agonist deoxycorticosterone acetate or aldosterone plus high salt intake and (2) angiotensin II infusion in hypercholesterolemia mice. Aortic BMAL1 was upregulated by deoxycorticosterone acetate-salt, and deletion of BMAL1 in SMCs selectively upregulated TIMP4 (tissue inhibitor of metalloproteinase 4) and suppressed deoxycorticosterone acetate-salt–induced MMP (matrix metalloproteinase) activation and elastin breakages. Moreover, BMAL1 bound to the
Timp4
promoter and suppressed
Timp4
transcription.

Conclusions—
These results reveal an important, but previously unexplored, role of SMC BMAL1 in AAA. Moreover, these results identify TIMP4 as a novel target of BMAL1, which may mediate the AAA protective effect of SMC BMAL1 deletion.
Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke
Authors: Ducroux Celina , Di Meglio Lucas , Loyau Stephane , Delbosc Sandrine , Boisseau William , Deschildre Catherine , Ben Maacha Malek , Blanc Raphael , Redjem Hocine , Ciccio Gabriele , Smajda Stanislas , Fahed Robert , Michel Jean-Baptiste , Piotin Michel , Salomon Laurence , Mazighi Mikael , Ho-Tin-Noe Benoit , Desilles Jean-Philippe 
Published: February 2018

Background and Purpose—
Neutrophil Extracellular Traps (NETs) are DNA extracellular networks decorated with histones and granular proteins produced by activated neutrophils. NETs have been identified as major triggers and structural factors of thrombosis. A recent study designated extracellular DNA threads from NETs as a potential therapeutic target for improving tissue-type plasminogen activator (tPA)-induced thrombolysis in acute coronary syndrome. The aim of this study was to assess the presence of NETs in thrombi retrieved during endovascular therapy in patients with acute ischemic stroke (AIS) and their impact on tPA-induced thrombolysis.

Methods—
We analyzed thrombi from 108 AIS patients treated with endovascular therapy. Thrombi were characterized by hematoxylin/eosin staining, immunostaining, and ex vivo enzymatic assay. Additionally, we assessed ex vivo the impact of deoxyribonuclease 1 (DNAse 1) on thrombolysis of AIS thrombi.

Results—
Histological analysis revealed that NETs contributed to the composition of all AIS thrombi especially in their outer layers. Quantitative measurement of thrombus NETs content was not associated with clinical outcome or AIS pathogenesis but correlated significantly with endovascular therapy procedure length and device number of passes. Ex vivo, recombinant DNAse 1 accelerated tPA-induced thrombolysis, whereas DNAse 1 alone was ineffective.

Conclusions—
This study suggests that thrombus NETs content may be responsible for reperfusion resistance, including mechanical or pharmacological approaches with intravenous tPA, irrespectively of their etiology. The efficacy of a strategy involving an administration of DNAse 1 in addition to tPA should be explored in the setting of AIS.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT02907736.
Suppressive effect of black oat, Avena strigosa, KH1a on Meloidogyne spp.
Authors: Uesugi Kenta , Katsura Masaaki , Uwatoko Naohiro , Tateishi Yasushi , Murata Gaku , Iwabuchi Kei 
Published: February 2018

Summary
The suppressive effect of a black oat, Avena strigosa, breeding line KH1a on Meloidogyne spp. was examined in pot tests and on Meloidogyne incognita in pot and field tests. In pot tests, roots of black oats were examined 42-46 days after inoculation of 500 second-stage juveniles. There were significantly fewer egg masses on the roots of KH1a than on 12 black oat cultivars examined. KH1a was a poor host for four isolates of M. incognita, two isolates of M. arenaria and one isolate of M. javanica, and a non-host for one isolate of M. hapla. The effect of autumn and spring cropping of KH1a on soil nematode density was examined in M. incognita-infested fields. Nematode density after autumn cropping of KH1a was significantly lower than that after susceptible black oat, resulting in significantly lower Pf/Pi in KH1a (0.10 and 0.13) than in susceptible black oat (0.42 and 0.74). Damage indices of the succeeding crop, sweet potato, were significantly lower in KH1a plots than in susceptible black oat plots. In spring cropping, there were significantly fewer soil nematodes in KH1a plots than in susceptible black oat plots 3 weeks after cultivation. In both autumn and spring cropping, there was no significant difference in soil nematode density between KH1a and bare fallow. These results suggested that KH1a is a good alternative to current susceptible cultivars for the management of M. incognita.
Clinical response to treatment in inpatients with depression correlates with changes in activity levels and psychomotor speed
Authors: Averill Ian RE , Crowe Marie , Frampton Chris M , Beaglehole Ben , Lacey Cameron J , Jordan Jennifer , Wilson Lynere D , Douglas Katie M , Porter Richard J 
Published: February 2018

Background: Monitoring clinical response to treatment in depressed inpatients, particularly identifying early improvement, may be sub-optimal. This may impact adversely on patients through longer admissions and sub-optimal pharmacotherapy. Psychomotor speed is a prominent neuropsychological function which changes as recovery occurs. This study examines simple techniques used to quantify psychomotor change and their potential to contribute to monitoring recovery. Methods: Activity levels were continuously monitored in patients diagnosed with a major depressive episode from four acute psychiatric wards using two actigraphs (commercial and scientific) for 3 weeks and linear regression used to calculate a gradient to express rate of change. Psychomotor speed was assessed using the simple Coin Rotation Task. Mood and functioning were rated using the Quick Inventory of Depressive Symptoms, Clinical Global Impression Scale and Functioning Assessment Short Test. The assessments were completed at baseline and follow-up (3 weeks), and correlations were calculated for all change measures. Results: In all, 24 inpatients were recruited but not all completed baseline and follow-up measures. Change in activity count ( N = 16) and psychomotor speed ( N = 13) correlated significantly with improvement in clinical measures of depressive symptoms. Actigraphs were acceptable to hospital inpatients. Limitations: The limited size of this pilot study precludes the analysis of predictive power or the influence of other variables such as depression subtypes, age, gender or variations related to medications. Conclusion: Early change in simple activity and psychomotor speed warrant further investigation for utility in measuring treatment response in depressed inpatients.
Coming of age in a conflict area: Mental health, education, employment, migration and family formation in the southernmost provinces of Thailand
Authors: Ford Kathleen , Jampaklay Aree , Chamratrithirong Aphichat 
Published: February 2018

Objectives: Three southern provinces of Thailand – Pattani, Yala and Narathiwat – have been involved in a long period of unrest. Young people in these provinces have lived with this violence for many years. The objectives of this article are to assess the prevalence of psychiatric symptoms of young adults aged 18–24 years and to examine the perceived effects of the conflict on education, employment, social and religious life. Methods: Data were drawn from a probability sample of 2,053 Muslim adults aged 18–59 years conducted in 2014. Mental health was assessed using World Health Organization’s (WHO) Self Reporting Questionnaire (SRQ) of 20 questions, the Thai Mental Health questionnaire and a Happiness scale. In-depth interviews with 30 respondents were also used to assess the perceived effects of the conflict on daily life, education, employment and settlement. Results: Most respondents reported low levels of psychiatric symptoms, though a small proportion reported a large high enough number to be of concern. Most of them also reported high levels of happiness. Respondents who wished to migrate to work in another area reported more psychiatric symptoms and lower levels of happiness. Many respondents reported concerns about the violence in their daily lives, although some may have become habituated to its effects. There were many obstacles reported toward obtaining education including the threat of violence, financial cost and drug use. Male respondents had concerns about consequences of being suspected to be involved in the violence and drug use. The limited employment and the threat of violence were related to the plan to migrate or to settle in the three provinces. Conclusion: In summary, most young people in the area move forward with their lives and many display some habituation to the violence. However, the economic depression due to the violence and the threat of violence often affected their daily lives.
Two Orientations of the Self
Authors: Boyd Jeffrey H. 
Published: February 2018

This article defends the view that the Christian orientation of the self (i.e., soul) is that of a self-in-relationship-with-God, whereas the secular view of the self does not include that divine orientation. These different orientations lead to rival and incompatible value systems. To illustrate the two orientations of the self, this article will examine the secular mental health movement (SMHM), in which the author has been immersed for a quarter of a century. I seek to portray the spirit of the SMHM as a whole, without implying that any given SMHM practitioner suffers from that spirit. The spirit in question is definitely not-God-centered and may even promote the self as an idol. An idol is defined as anything or anybody that a person loves
The effects of Internet-based exercise compared with supervised group exercise in people with type 2 diabetes: a randomized controlled study
Authors: Akinci Buket , Yeldan Ipek , Satman Ilhan , Dirican Ahmet , Ozdincler Arzu Razak 
Published: February 2018

Objectives: To compare the effects of Internet-based exercise on glycaemic control, blood lipids, body composition, physical activity level, functional capacity, and quality of life with supervised group exercise in patients with type 2 diabetes. Design: Single-blind, randomized controlled study. Setting: A Faculty of Health Sciences. Subjects: A total of 65 patients with type 2 diabetes (47 women, 18 men). Intervention: Group A ( n = 22), control group – physical activity counselling once with a brochure. Group B ( n = 22), supervised group-based exercise, three days per week for eight weeks. Group C ( n = 21), Internet-based exercise following the same programme via a website. Main measures: Primary outcomes – glycosylated haemoglobin, fasting blood glucose, high-density and low-density lipoprotein, triglyceride, and cholesterol. Secondary outcomes – waist and hip circumferences, body mass index, number of steps, six-minute walking test, and Euro-Quality of Life-5 Dimension. Results: After treatment, glycaemic control (mean change for Group B; Group C; –0.80%, –0.91%, P = 0.003), waist circumference (–4.23 cm, 5.64 cm, P = 0.006), and quality of life (0.26, 0.15, P = 0.013) significantly improved in both training groups compared with the control group. Fasting blood glucose (–46.86 mg/dL, P = 0.009) and hip circumference (–2.7 cm, P = 0.011) were significantly decreased in Group B and total cholesterol (–16.4 mg/dL, P = 0.028), six-minute walking distance (30.5 m, P = 0.01), and number of steps (1258.05, P = 0.023) significantly improved in Group C compared with control group. Group B and Group C changed with equal magnitude. Conclusion: In type 2 diabetes, supervised group-based and Internet-based exercise can improve equally glycaemic control, waist circumference, and quality of life, and both are better than simply counselling.
Predictive Factors of Hamstring Tendon Regeneration and Functional Recovery After Harvesting: A Prospective Follow-up Study
Authors: Suijkerbuijk Mathijs A.M. , Reijman Max , Oei Edwin H.G. , van Meer Belle L. , van Arkel Ewoud R.A. , Meuffels Duncan E. 
Published: February 2018

Background: Semitendinosus and gracilis tendons may regenerate after harvesting for ligament reconstruction procedures. However, predictive factors of tendon regeneration and the extent of functional recovery remain unclear. Purpose: To identify predictive factors for hamstring tendon regeneration and to examine the morbidity of nonregenerated hamstring tendons. Study Design: Cohort study; Level of evidence, 3. Methods: Of the 154 patients who were included in a prospective follow-up study, 79 underwent reconstruction of the anterior cruciate ligament entailing the hamstring tendons and met the following inclusion criteria: (1) anterior cruciate ligament rupture diagnosed by physical examination and magnetic resonance imaging (MRI), (2) MRI within 6 months after trauma, (3) age between 18 and 45 years, and (4) 2-year follow-up MRI data available. Hamstring tendon regeneration was assessed as complete if a tendon-like structure could be visualized at the level of the joint line or more cranially. Patient characteristics—such as age, sex, body mass index, alcohol/nicotine use, activity level (Tegner scores), and functional instability (1-legged hop test)—were evaluated preoperatively and at 2 years to determine predictive factors for tendon regeneration or examine functional recovery of hamstring tendon regeneration. Results: At 2 years’ follow-up, 67.1% of the patients showed regeneration of semitendinosus tendons, 81.0% of gracilis tendons, and 59.5% of both tendons. The likelihood of semitendinosus tendon regeneration significantly decreased with aging (odds ratio [OR], 0.92 change per year of age; 95% CI, 0.84-0.99; P = .03) and smoking (OR, 0.20; 95% CI, 0.05-0.77; P = .02). No predictive factor was found for gracilis tendon regeneration. Regeneration of the semitendinosus and gracilis tendons was negatively related with smoking (OR, 0.22; 95% CI, 0.06-0.79; P = .02). Patients without regeneration showed similar postoperative visual analog scale scores during physical activity, similar Tegner scores, and a significant decrease of the upper leg circumference, as compared with their preoperative results. Regardless of the regeneration status, 1-legged hop test results significantly increased at 2-year follow-up. Conclusion: Hamstring tendon regeneration occurs less frequently in older patients and in smokers. However, absence of regenerated tendons does not seem to cause a loss of function.
A case for identifying smoking in presentations to the emergency department with suicidality
Authors: Wilhelm Kay , Handley Tonelle , Reddy Prasuna 
Published: February 2018

Objectives: The aim of this study was to identify mental health and lifestyle factors predicting smoking among people at high risk of suicidal behaviour. Methods: Participants ( n = 363) completed self-report mental health and lifestyle measures at first appointment in a hospital clinic following presentation to the emergency department for deliberate self-harm or suicidal ideation. Results: The rate of daily smoking in this group, 61.4%, is more than four times the rate observed in the general population. Those with a history of previous deliberate self-harm were twice as likely to be smokers. Each one-point increase in poor health behaviours increased the odds of smoking by 22%. Conclusions: Identifying and managing smoking and related lifestyle behaviours are important considerations in routine clinical assessments.
Electronic Information Systems: In search of responsive social work
Authors: Devlieghere Jochen , Roose Rudi 
Published: February 2018

Summary The informational context in which social work has been operating over the past decade has gained much more significance. In this context, Electronic Information Systems are often implemented with the aim of being responsive to the needs of children and families. However, research has critically identified some major concerns with using Electronic Information Systems in ways that tend to reduce social work to a technical practice. As a result, practitioners and managers are using their discretion to shape and bend regulations precisely in order to achieve responsive social work practice. In this paper, our aim is to capture the meaning of these strategies for the development of responsive social work. To do so, we interviewed social practitioners working with Electronic Information Systems on a daily basis. Findings Our results show how practitioners develop a diversity of strategies to recreate the relational aspect of social work, thereby challenging the hypothesis that this was curtailed by the use of Electronic Information Systems. Applications By fleshing out the meaning of the strategies practitioners use in their daily practice, we aim to contribute to the contemporary debate about the use of these strategies in social work practice. At the same time, it is also important to understand the meaning of these strategies in relation to the development of responsive social work as this development cannot be reduced to a mere relational practice where principles of justice, equality and solidarity are not equally considered.