bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Large, Multicenter, Retrospective Study on Efficacy and Safety of Stereotactic Body Radiotherapy (SBRT) in Oligometastatic Ovarian Cancer (MITO RT1 Study): A Collaboration of MITO, AIRO GYN, and MaNGO Groups
Authors: Macchia Gabriella , Lazzari Roberta , Colombo Nicoletta , Laliscia Concetta , Capelli Giovanni , D'Agostino Giuseppe Roberto , Deodato Francesco , Maranzano Ernesto , Ippolito Edy , Ronchi Sara , Paiar Fabiola , Scorsetti Marta , Cilla Savino , Ingargiola Rossana , Huscher Alessandra , Cerrotta Anna Maria , Fodor Andrei , Vicenzi Lisa , Russo Donatella , Borghesi Simona , Perrucci Elisabetta , Pignata Sandro , Aristei Cynthia , Morganti Alessio Giuseppe , Scambia Giovanni , Valentini Vincenzo , Jereczek-Fossa Barbara Alicja , Ferrandina Gabriella 
Published: October 2019

Abstract

Background
Recent studies have reported improvement of outcomes (progression-free survival, overall survival, and prolongation of androgen deprivation treatment-free survival) with stereotactic body radiotherapy (SBRT) in non-small cell lung cancer and prostate cancer. The aim of this retrospective, multicenter study (MITO RT-01) was to define activity and safety of SBRT in a very large, real-world data set of patients with metastatic, persistent, and recurrent ovarian cancer (MPR-OC).

Materials and Methods
The endpoints of the study were the rate of complete response (CR) to SBRT and the 24-month actuarial local control (LC) rate on “per-lesion” basis. The secondary endpoints were acute and late toxicities and the 24-month actuarial late toxicity-free survival. Objective response rate (ORR) included CR and partial response (PR). Clinical benefit (CB) included ORR and stable disease (SD). Toxicity was evaluated by the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) and Common Terminology Criteria for Adverse Events (CTCAE) scales, according to center policy. Logistic and Cox regression were used for the uni- and multivariate analysis of factors predicting clinical CR and actuarial outcomes.

Results
CR, PR, and SD were observed in 291 (65.2%), 106 (23.8%), and 33 (7.4%) lesions, giving a rate of CB of 96.4%. Patient aged ≤60 years, planning target volume (PTV) ≤18 cm3, lymph node disease, and biologically effective dose α/β10 &gt; 70 Gy were associated with higher chance of CR in the multivariate analysis. With a median follow-up of 22 months (range, 3–120), the 24-month actuarial LC rate was 81.9%. Achievement of CR and total dose &gt;25 Gy were associated with better LC rate in the multivariate analysis. Mild toxicity was experienced in 54 (20.7%) patients; of 63 side effects, 48 were grade 1, and 15 were grade 2. The 24-month late toxicity-free survival rate was 95.1%.

Conclusions
This study confirms the activity and safety of SBRT in patients with MPR-OC and identifies clinical and treatment parameters able to predict CR and LC rate.
Wi-Fi and LTE-LAA coexistence problems, challenges and features in 5GHz unlicensed bandwidth
Authors: SULAİMANİ Maqsood , ARI Seçkin 
Published: October 2019

The
demand for high data rate and stable Quality of Service (QoS) from cellular
networks’ subscribers is a huge challenge for cellular operators. To overcome
this issue (providing high data rate and stable QoS) it requires more
bandwidth. The lack of licensed bandwidth and also its high cost make it hard
for operators to overcome this issue. To find a fair solution and expand the
capacity of cellular networks, operators started deployment of Long Term
Evolution (LTE) in unlicensed bandwidth, exactly utilizing 5GHz unlicensed
bandwidth in small cell scenarios. The extension of LTE to the 5GHz unlicensed
bandwidth where it is already in used by Wi-Fi will create huge coexistence
problems between Wi-Fi and LTE. It results from that Wi-Fi and LTE have
different channel access mechanisms. This paper presents the channel access
mechanisms of Wi-Fi and LTE-Licensed Assisted Access (LTE-LAA), coexistence problems,
challenges, privileges, coexistence features of LTE and Wi-Fi and Finally, we
conducted the simulation for LAA based on Listen Before Talk (LBT) mechanism and Wi-Fi to find that how LAA with
LBT mechanism is friendly to the Wi-Fi networks when they share the same
bandwidth. The simulation results illustrate that LAA based on LBT channel
access mechanism by alone cannot bring a fair coexistence between these two
technologies, it needs further improvement.
Cabozantinib: from studies to clinical practice
Authors: Matveev V. В. , Olshanskaya A. S. , Volkova M. I. 
Published: October 2019

Disseminated renal cell carcinoma is an immunogenic tumor in which cytokine immunotherapy is usually used as the second-line treatment. It is associated with a low frequency of objective responses and short progression-free survival. Modern studies resulted in more effective treatment regimens based on new high-affinity TKI multikinases (cabozantinib, lenvatinib), as well as immuno-oncological drugs that can specifically block intercellular transmission of anti-immunogenic signal (PD-1 inhibitors) (nivolumab, pembrolizumab) or its ligand type 1 (PD-L1) (avelumab), antigen type 4 associated with anticytotoxic T-lymphocyte (ipilimumab)). Cabozantinib is a 2nd generation multikinase inhibitor that blocks the receptors of growth factors MET, AXL, and VEGFR-2, which are involved in tumorigenesis and responsible for resistance to traditional antiangiogenic therapy in renal cell carcinoma. Registration studies have shown that cabozantinib together with combined targeted therapy is more effective in patients with favorable and intermediate prognosis, while the PD-1 inhibitor (nivolumab) – in patients with poor and intermediate prognosis.Objective:to analyze the results of cabozantinib studies and its possible use in the sequential treatment of disseminated renal cell carcinoma.
Perkütan endoskopik gastrostomide hipergranülasyon dokusu bakımına farklı bir bakış: Olgu sunumu ve literatürün gözden geçirilmesi
Authors: KAHVECİ Güldan , DAĞCI Selma , ATALAY Roni 
Published: October 2019

Perkütan endoskopik gastrostomi, çeşitli nedenlerle ağız yoluyla beslenemeyen hastalarda beslenme süresi 4-6 haftadan uzun sürecek ise endoskopik olarak karın duvarından girilerek mideye tüp yerleştirme işlemidir. Yatak başında işlemin yapılabilmesi ve düşük maliyetli olması nedeniyle sıklıkla tercih edilmektedir. Perkütan endoskopik gastrostomi tüpü yerleştirme sonrasında minör ve majör komplikasyonlar gelişebilmektedir. Minör komplikasyonlar arasında yer alan hiperganülasyon doku gelişimi tedavi edilmezse enfeksiyona, enfeksiyon tedavi edilmez ise nekrotizan fasiite neden olabilmekte ve nadir de olsa ölümle sonuçlanabilmektedir. Hastaların beslenmesinin kesintiye uğramaması için komplikasyonların önlenmesi büyük önem taşımaktadır. Olgu sunumumuzda perkütan endoskopik gastrostomi tüpünün giriş yerinde oluşan komplikasyonlar bildirilmiş, olası nedenleri tartışılmış, minör komplikasyonlar arasında yer alan hipergranülasyon dokusunun bakımı %10 povidon iyot solüsyonu (batikon, betadin) ile yapılmış bir vaka sunulmuş ve konu ile ilgili literatür derlenmiştir.
Identification of causative pathogen and its antibiotic sensitivity in cases of preterm premature rupture of membranes
Authors: Kandukuri Sai Prasanna , Chadalawada Ramamani , Gollapalli Bhavishya 
Published: October 2019

Background: Pre-labor rupture of membranes is defined as amniotic membrane rupture before the onset of labor contractions, and if it happens before 37 weeks, it is called preterm premature rupture of membranes (PPROM). Several organisms commonly present in the vaginal tract are E.coli, Group-B streptococci, staphylococcus aureus, chlamydia trachomatis, Gardnerella vaginalis and Enterococcus faecalis which secrete proteases that degrade collagen thereby weakening the fetal membranes leading to PPROM. Appropriate antibiotic therapy has a significant role in the prevention and treatment of maternal and neonatal complications.Methods: This was a prospective observational study done in the department of obstetrics and gynaecology, Narayana medical college, Nellore. Selectively 100 patients with complaint of PPROM admitted to labor room were included in the study. Diagnosis of membrane rupture was established by speculum examination, and high vaginal swabs are taken and sent to laboratory for identifying bacteria using gram staining and cultured in aerobic and anaerobic methods. Antimicrobial susceptibility testing of the organisms was performed by disk diffusion method by Kirby and Bauer.Results: Out of 100, high vaginal swabs had growth in 82 patients, and 18 were sterile. The repeatedly isolated organism in patients with PPROM is E.coli amounting 32%, followed by candidal species 20%. Staphylococci are scoring 11% and enterococci 8%. However, organisms like gardenella vaginalis and Group B streptococcus are least common with a score of 6% and 5% respectively. In this study, E.coli is highly sensitive to tigecycline, colistin 100% each and highly resistant to gentamycin and amikacin.Conclusions: In this study, E.coli is related to the maximum number of cases with preterm premature rupture of membranes. Appropriate use of antibiotics significantly lowers maternal morbidity and neonatal mortality.
The Effectiveness of Family Peer Group Education Intervention on Family Support of Type II Diabetes Mellitus Patients
Authors: Irawan Erna , Alfatih Hudzaifah , . Faisal 
Published: October 2019

Background: The number of people with diabetes mellitus is increasing with the most cases being Type II Diabetes Mellitus which is a chronic condition and if not treated seriously can cause complications such as kidney disease, amputation and blindness. Families play an important role in prevention and help deal with patients’ disease problems. One of the factorsthat inﬂuence the health of DM patientsis family support. It has a signiﬁcant inﬂuence on the success of diabetes management. The most inﬂuential factor for family support is health knowledge and education. Peer education intervention group is one type of health education that provides increased knowledge, psychosocial, and more effective expenditure, rather than personal counseling. Family as a function of health that requires peers from their own family members.
Objective: The purpose of this study was to identify the effectiveness of the peer group Educationin tervention family against the family support of type II DM patients.
Methods: The designused in this study included the randomized pretest and -posttest control group design. Sampling was done by purposive sampling with family inclusion criteria in which one family member suffered from type II DM, stayed with the patient, and was willing to become a respondent. Data collection is using family support questionnaire. Data analysis used a t-test.
Results: The results showed there were signiﬁcant differences between pre and post intervention. The peer group education intervention increased the family support of type II DM patients after the post intervention (p = 0.00). the peer group education intervention family increases the family support of type II DM patients in the intervention group compared to controls (p =0.00).
Conclusion: The results showed that peer group intervention education was more signiﬁcant than health education usually in increasing the family support of diabetes mellitus patients,so that it could be used as an intervention choice for community nurses in increasing family support for DM patients.
The Relationship between Exclusive Breastfeeding (ASI) and Mother Heightwith Incident Rates Stunting among Child Age 2-5 Years In Barombong Public Health Center, Gowa, Sulawesi Selatan
Authors: . Mikawati , Lusiana Evi , . Hasriany 
Published: October 2019

Background: The incidence of stunting is one of the nutritional problems experienced by toddlers in the world today. Indonesia ranks ﬁfth for stunting in the world, which is around 37% (nearly 9 million) children. Toddlers with stunting will have a level of intelligence that is not optimal, making children more vulnerable to disease and in the future can be at risk of decreasing levels of productivity. In the working area of the Barombong Public Health Center, it was reported that nutrition issues, especially exclusive breastfeeding for toddlers and pregnant women, were still the focus of attention from the current Puskesmas work plan. So that this problem could be a risk factor for stunting incidents experienced by many toddlers in the work area of Barombong Health Center, Gowa Regency, South Sulawesi.
Objectives: This study aims to determine how the relationship between exclusive breastfeeding and maternal heightwiththeincidenceofstuntingininfantsaged2-5yearsattheBarombongPublic HealthCenter, Gowadistrict, SouthSulawesi.
Methods:A cross sectional approach was used, this study conducted in August 2018 with the total population was 56 toddlers were selected using purposive sampling techniques. Data collection was carried out by researcher assisted used questionnaires. Forty nine toddlers met inclusion criteria. Parental height data is obtained by measuring high using a precision microtoise of 0.1 cm and the incidence of stunting is obtained by measuring the nutritional status with toddler’sheightbyage(TB/U)islessthan-2SDandchisquaretestwasusedtodata analysis.
Results: Theresultswereprevalenceofshortfathersis1%,andshortmothers is 89.8%. The prevalence of children under ﬁve did not get exclusive breastfeeding is 75.5% and the incidence of stunting is 83.7% and very short 16.3%.From the bivariate test results there was no relationship of father’s height with stunting events chi square test results (p-value 1.00) of parents with stunting events, there was a relationship of maternal height with stunting events chi square test results (p-value 0.026), there is a relationship between exclusive breastfeeding with the stunting event of the chi square test results (p-value 0.015).
Conclusion: the conclusion of this study is need family approach and providing education to the family as well as best nutritional intake in the breast milk at the beginning of life in order to prepare the ﬁrst 1000 days of children life to avoid Stunting.
SOCIO-CULTURAL CONDITIONS OF EDUCATIONAL ENVIRONMENT DEVELOPMENT
Authors: Aleksandrovna Aleksandrova Ekaterina , Viktorovna Rudenko Irina , A. Kolesnikov Mikhail , Valerievna Garipova Venera , V. Kuznezov Sergye 
Published: October 2019

Purpose: The article conducts the study socio-cultural conditions of educational environment development.
Methodology: The criteria for assessing the quality of synchronization actions of heads of educational institutions are determined as well as the criteria for assessing the quality of inter-agency cooperation and self-organization of actors of educational systems and the cooperation among themselves.
Result: We found out that the current process of educational environment development is in crisis at the level of goal-setting; selection of approaches and principles, forms, methods, and means; selection of criteria for the effectiveness of actors’ activities.
Applications: This research can be used for universities, teachers, and students.
Novelty/Originality: In this research, the model of socio-cultural conditions of educational environment development is presented in a comprehensive and complete manner.
STUDENT ATTITUDE TO DEMOGRAPHIC SITUATION IN RUSSIA
Authors: A. Yarygina Nelya , F. Piralova Olga , G. Lichutina Marina , M. Yudina Anna , V. Ilkevich Boris , A. Kurbanov Rashad , M. Belyalova Asiya , V. Popova Olga 
Published: October 2019

Purpose of the study: Since the new generation is the main entity of material and social benefits’ renewal process of any state, the article aims to identify the students’ attitude to the demographic situation in Russia. It is the younger generation of different age groups that is the main labor unit of the state population. Relevant is the fact that the issues of demography are a global challenge of self-organizing society. The purpose of the article is to identify the students’ attitude to the demographic situation in Russia, as well as to consider various models of reproductive behavior. Methodology: The leading methods for the study of this problem is the survey method, which allows to make a qualitative analysis of the characteristics of the students’ attitude to the demographic situation in Russia and to establish the subjective position of students regarding demographic development. Results: The article reveals that the following administrative and legal measures contribute to the improvement of the demographic situation in the country (legislative acts regulating the marriage age, divorce, attitude to abortion and contraception, the status of mother and children in the divorce, working women’s labor regime); economic measures (paid leave, various benefits at child’s birth, preferential credit conditions if necessary, tax and housing benefits); educational measures (formation of public opinion, the core and standards of demographic behavior, determination of attitude to religious norms, traditions and customs, family planning policy, sexual education of youth). The authors established a high level of awareness of students about the demographic situation in the country; the presence of anxiety about this situation. Applications of this study: The data obtained in the work can be used in sociology, social psychology, political science, as well as for further theoretical development of this issue. Novelty/Originality of this study: The study revealed a high level of awareness of young people about the demographic situation in the country, certain anxiety about this situation. However, young people are not in a hurry to participate in the solution of demographic problems, referring mainly to the difficulties of material nature. This indicates the need for more careful consideration of measures of state support for young families, taking into account the research of their opinion on this matter.
Çocukları Suça Sürükleyen Çevresel Nedenler: Sosyal Bağ ve Sosyal Öğrenme Teorileri Işığında Bir Değerlendirme
Authors: BAĞIŞ Radiye Canan 
Published: October 2019

Bireysel ve çevresel nedenler çocukların suça sürüklenmesine etki etmekte, bireysel nedenlerin tek başına belirleyiciliği bulunmamaktadır. Çevresel nedenlerin başında aile gelmektedir. Ailede başlayan sosyalleşme sürecinin sekteye uğraması, bu sürecin okul, akran grupları, çalışma yaşamı ve kitle iletişim araçlarının etkisiyle hatalı ve eksik bir şekilde devam etmesi çocukların suça yönelmesine neden olmaktadır. Suçu açıklamaya yönelik olarak biyolojik, psikolojik ve sosyolojik suç teorileri bulunmaktadır. Bu araştırmada sosyolojik suç teorileri üzerinde durulmaktadır. Araştırmanın amacı sosyal bağ teorisi ve sosyal öğrenme teorileri ışığında çocuk suçluluğunun nedenlerinin bir değerlendirmesini yapmaktır. Araştırmada suçun öğrenilen bir davranış olduğu ve bireyin toplumla bağının zayıflamasının suç işleme olasılığını arttırdığı varsayımlarından hareket edilmektedir.
A systematic review of the dimensions of transit-oriented urban planning and design = Una revisión sistemática de categorías para la evaluación de la planificación y el diseño urbano orientado al transporte público
Authors: Abdi Mohammad Hamed 
Published: October 2019

AbstractDue to valuable global experiences regarding Transit Oriented Development (TOD) as a context-sensitive strategy, updating the planning dimensions and even post-performance imperfections is inevitable by which reinforcing new urban plans could be dramatically pursued. Therefore, the present study aimed to highlight the most significant dimensions of transit-oriented urban planning all over the world. To this end, relevant qualitative studies were systematically reviewed through a Qualitative Meta-synthesis study. A total of 17 peer-reviewed articles and complementary databases searched during May-August 2018 led to a number of 6522 records among which 23 cases met the eligibility criteria and quality appraisal for inclusion in the final list. Then, the results were interpreted by using qualitative content analysis and a development-driven model was drawn by a classification as the general TOD planning themes including place development, policy development, process development, and sustainable development. Based on the results of the study, 30 planning dimensions pertinent to TOD were listed. The results helped retrieve and collect the up-to-date dimensions and interpret the changes appeared during the decades of planning.Resumen Debido a las valiosas experiencias globales realizadas en Desarrollo Orientado al Transporte Sostenible (DOTS)’, una estrategia sensible al contexto es inevitable actualizar la planificación e incluso las imperfecciones posteriores al desempeño, a las que se podría seguir reforzando los nuevos planes urbanos. Este estudio pretende resaltar las dimensiones más importantes para la planificación urbana orientada al tránsito en todo el mundo. Para ello, las investigaciones cualitativas relevantes se revisarán sistemáticamente a través de un estudio de meta-síntesis cualitativa (QMS). La búsqueda de 17 artículos revisados por pares y bases de datos complementarias de mayo a agosto de 2018 dio lugar a 6522 registros, de los cuales 23 cumplieron con los criterios de elegibilidad y la evaluación de calidad para estar en la lista final. Usando el análisis de contenido cualitativo, los resultados se interpretaron, y por una clasificación, se elaboró un modelo impulsado por el desarrollo como temas generales de planificación de DOTS, a saber, Desarrollo del desarrollo, Desarrollo de políticas, Desarrollo de procesos y Desarrollo sostenible. Con respecto a los hallazgos del estudio, se enumeran 30 dimensiones de planificación relevantes para DOTS. Los resultados ayudarán a recuperar y recopilar las dimensiones actualizadas y a interpretar los cambios