bluuebunny/crossref_metadata_2025_split huggingface dataset:
In2Se3 Synthesized by the FWF Method for Neuromorphic Computing
Authors: Shin Jaeho , Jang Jingon , Choi Chi Hun , Kim Jaegyu , Eddy Lucas , Scotland Phelecia , Martin Lane W. , Han Yimo , Tour James M. 
Published: November 2024

AbstractThe development of next‐generation in‐memory and neuromorphic computing can be realized with memory transistors based on 2D ferroelectric semiconductors. Among these, In2Se3 is the interesting since it possesses ferroelectricity in 2D quintuple layers. Synthesis of large amounts of In2Se3 crystals with the desired phase, however, has not been previously achieved. Here, the gram‐scale synthesis of α‐In2Se3 crystals using a flash‐within‐flash Joule heating method is demonstrated. This approach allows the synthesis of single‐phase α‐In2Se3 crystals regardless of the conductance of precursors in the inner tube and enables the synthesis of gram‐scale quantities of α‐In2Se3 crystals. Then, α‐In2Se3 flakes are fabricated and used as a 2D ferroelectric semiconductor FET artificial synaptic device platform. By modulating the degree of polarization in α‐In2Se3 flakes according to the gate electrical pulses, these devices exhibit distinct essential synaptic behaviors. Their synaptic performance shows excellent and robust reliability under repeated electrical pulses. Finally, it is demonstrated that the synaptic devices achieve an estimated learning accuracy of up to ≈87% for Modified National Institute of Standards and Technology patterns in a single‐layer neural network system.
Wide‐Spectrum Nano‐Antibiotics Based on TPA‐Py@AuNCs⊂BSA for Multimodal Synergistic Therapy of Drug‐Resistant Bacteria and Wound Infections
Authors: Xu Feng‐Rui , Zhang Guo‐Ling , Zhang Kai , Chen Pu , Wang Qianqian , Pan Yuezhe , Tang Ben Zhong , Feng Hai‐Tao 
Published: November 2024

ABSTRACTTo meet the high requirements of biomedical applications in antimicrobial agents, it is crucial to explore efficient nano‐antimicrobial agents with no resistance and good biocompatibility for treating infected wounds. In this study, composite nano‐antibiotic TPA‐Py@AuNCs⊂BSA nanoparticles (TAB NPs) are prepared using hollow mesoporous Au nanocages (AuNCs) loaded with a photosensitizer (namely TPA‐Py) with D‐π‐A structure showing aggregation‐induced emission properties. When TPA‐Py is encapsulated in the cavity of AuNCs, its fluorescence is suppressed. In the presence of photothermal induction, TPA‐Py can be released from the AuNCs, allowing for the restoration of fluorescence illumination and the specific imaging of Gram‐positive bacteria. TAB NPs demonstrate outstanding antimicrobial activity against a variety of bacteria, and this multimodal antimicrobial property does not lead to the development of bacterial resistance. In vitro experiments show that TAB NPs could eliminate bacteria and ablate bacterial biofilm. In vivo experiments show that the synergistic antimicrobial effect of TAB NPs has a significant positive impact on the treatment of infected wounds, including rapid antibacterial action, promotion of M2 macrophage polarization, and enhancement of chronic wound healing. This study provides an effective strategy for developing wide‐spectrum nano‐antibiotics for the ablation of bacterial biofilms and the treatment of infected wounds.
The Impact of the COVID‐19 Pandemic on Waist and Hip Circumference and Selected Indicators Related to It Among Adolescents From the Kraków (Poland) Population
Authors: Artymiak Paulina , Żegleń Magdalena , Kryst Łukasz 
Published: November 2024

ABSTRACTObjectivesThe aim of the study was to assess changes in waist and hip circumference, as well as the waist‐to‐hip ratio (WHR) and waist‐to‐height ratio (WHtR) indices among adolescents (11–15‐year‐olds) from the Kraków during the COVID‐19 pandemic.MethodsCross‐sectional studies were conducted in four main districts of the city in the years 2020 and 2022. The study group consisted of 1662 people. Measurements of height, waist circumference, and hip circumference were taken. The collected data were used to calculate the WHR and WHtR indices. Statistical analyses were performed using two‐way ANOVA and post hoc Tukey's test, as well as the Kruskal–Wallis test, depending on the normality of distribution.ResultsAn increase in hip circumference was observed in most age groups of both sexes. Among 14–15‐year‐old boys, an increase in waist circumference was observed, while among girls, the majority of cohorts showed the opposite trend. Additionally, in most age groups, a decrease in the values of WHR and WHtR indices was observed in both sexes, except for boys aged 14–15.ConclusionThe study found that government‐imposed restrictions related to the COVID‐19 pandemic had an impact on waist circumference, hip circumference, WHR, and WHtR indicators among adolescents aged 11–15 from Kraków. While some results showed regression, suggesting potential factors such as reduced physical activity or increased screen time contributing to deteriorating outcomes. On the other hand, not all results changed, which may be attributed to the absence of modifications in dietary habits or physical activity as government restrictions ceased.
Cyclic Vomiting Syndrome in Patients Affected by Jansen–de Vries Syndrome: Results From an International Survey
Authors: Pizzol A. , Adams K. A. , de Vries B. B. A. , Curry C. J. , Calvo P. L. 
Published: November 2024

ABSTRACTJansen–de Vries syndrome (JdVS) is an autosomal dominant neurodevelopmental disorder with intellectual disability and gastrointestinal (GI) abnormalities, including recurrent vomiting. This study aimed to understand the frequency and severity of GI symptoms in JdVS patients and to investigate the potential association with cyclic vomiting syndrome (CVS), which has not been previously reported. An international online survey assessed the prevalence and features of CVS and GI disorders in JdVS patients using Rome IV Criteria. The anonymous survey was conducted via Google Forms in April 2021. A total of 21 patients/guardians responded to the survey. The average age at JdVS diagnosis was 8.22 years (range: 1–42). Of the respondents, 6 (28.5%) had a CVS diagnosis, 5 (23.8%) had migraine, and 2 (9.5%) had abdominal migraine. Additionally, 8 (38%) had gastroesophageal reflux disease (GERD) and 8 (38%) had functional constipation. An analysis targeted questions showed that 7 (33%) met the Rome IV Criteria for CVS but were undiagnosed, leading to a CVS prevalence of 61% in this cohort. This study highlights a high prevalence of CVS in JdVS patients and underscores the need for increased awareness and accurate diagnosis to address misdiagnosis.
Modulating Interfacial Solvation via Ion Dipole Interactions for Low‐Temperature and High‐Voltage Lithium Batteries
Authors: Liang Ping , Li Jinhan , Dong Yang , Wang Zhaodong , Ding Guoyu , Liu Kuiming , Xue Linlin , Cheng Fangyi 
Published: November 2024

AbstractExtending the stability of ether solvents is pivotal for developing low‐temperature and high‐voltage lithium batteries. Herein, we elucidate the oxidation behavior of tetrahydrofuran with ternary BF4−, PF6− and difluoro (oxalato) borate anions and the evolution of interfacial solvation environment. Combined in situ analyses and computations illustrate that the ion dipole interactions and the subsequent formation of ether‐Li+‐anion complexes in electrolyte rearrange the oxidation order of solvated species, which enhances the electrochemical stability of ether solvent. Furthermore, preferential absorption of anions on the surface of high‐voltage cathode favors the formation of a solvent‐deficient electric double layer and an anti‐oxidation cathode electrolyte interphase, inhibiting the decomposition of tetrahydrofuran. Remarkably, the formulated electrolyte based on ternary anion and tetrahydrofuran solvent endows the LiNi0.8Co0.1Mn0.1O2 cathode with considerable rate capability of 5.0 C and high capacity retention of 93.12 % after 200 cycles. At a charging voltage of 4.5 V, the Li||LiNi0.8Co0.1Mn0.1O2 cells deliver Coulombic efficiency above 99 % at both 25 and −30 °C.
Programming the Dynamic Range of Nanochannel Biosensors for MicroRNA Detection Through Allosteric DNA Probes
Authors: Shang Zhiwei , Ding Defang , Deng Zixuan , Zhao Jing , Yang Mengyu , Xiao Yuling , Chu Wenjing , Xu Shijun , Zhang Zhicheng , Yi Xiaoqing , Lin Meihua , Xia Fan 
Published: November 2024

AbstractSolid‐state nanochannel biosensors are extensively utilized for microRNA (miRNA) detection owing to their high sensitivity and rapid response. However, conventional nanochannel biosensors face limitations in their fixed dynamic range, restricting their versatility and efficacy. Herein, we introduce tunable triblock DNA probes with varying affinities for target miRNA to engineer solid‐state nanochannel biosensors capable of customizable dynamic range adjustment. The triblock DNA architecture comprises a poly‐adenine (polyA) block for adjustable surface density anchoring, alongside stem and loop blocks for modulating structural stability. Through systematic manipulation of these blocks, we demonstrate the ability to achieve diverse target binding affinities and detection limits, achieving an initial 81‐fold dynamic range. By combining probes with various affinities, we extend this dynamic range significantly to 10,900‐fold. Furthermore, by implementing a sequestration mechanism, the effective dynamic range of the nanochannel biosensor is narrowed to only a 3‐fold span of target concentrations. The customizable dynamic range of these advanced nanochannel biosensors makes them highly promising for a broad spectrum of biomedical and clinical applications.
Dication Disulfuranes as Photoactivatable Sources of Radical Organocatalysts
Authors: Song Kun‐Long , Meyrelles Ricardo , Pilet Guillaume , Maryasin Boris , Médebielle Maurice , Merad Jérémy 
Published: November 2024

AbstractThe recent development of photoredox and energy transfer catalysis has led to a significant expansion of visible‐light‐driven chemical transformations. These methods have demonstrated exceptional efficiency in converting a wide range of substrates into radical intermediates and generating open‐shell catalytic species. However, the simplification of catalytic systems and the direct generation of highly reactive radical organocatalysts through direct visible‐light irradiation from stable precatalysts remains largely an unrealized goal. This challenge is mainly due to the limited availability of precatalysts that are responsive to visible light. Herein, we introduce a new class of bench‐stable dicationic disulfuranes, which release highly reactive thiyl radicals upon blue‐light excitation. Spectroscopic and computational studies reveal that this reactivity arises from a combination of structural features and intermolecular interactions. This family of molecules has been employed to catalyze radical cascades previously incompatible with photoredox conditions, enabling the efficient formation of 1,2‐dioxolanes and 1,3‐hydroxyketones in excellent yields and short reaction times.
A Novel Mn‐MOF Sensitive Detection of Antibiotic Difloxacin Hydrochloride in Water
Authors: Wang Xiaomei , Pan Jiajun , Quan Yue , Liu Lanqing , Yang Tao , Zhou Xinhui , You Yujian , Xiao Hongping 
Published: November 2024

ABSTRACTAntibiotic pollution in hydrophytic ecosystems has aroused widespread notice due to its adverse impact on both the ecological environment and human physical well‐being. Thus, the development of effective antibiotic detection materials is not only urgently needed but is also challenging. Herein, the luminescent metal–organic framework [Mn3/2(HBCTC)·5H2O] (1) was successfully synthesized based on [9,9′‐bicarbazole]‐3,3′,6,6′‐tetracarboxylic acid (H4BCTC) under solvothermal conditions. Compound 1 can be employed as a fluorescent probe to detect antibiotic difloxacin hydrochloride (DIF) in water, demonstrating a remarkable linear relationship between fluorescence intensity ratio I0/I and the concentration of DIF (0–40 μM), with Ksv of 79,405 M−1 and LOD of 114 nM. More importantly, 1 represents the first fluorescent sensing material based on MOF for the detection of DIF, exhibiting exceptional selectivity, sensitivity, and anti‐interference capability. Furthermore, the mechanism of fluorescence quenching was studied comprehensively.
Characterization of Genetic Landscape and Novel Inflammatory Biomarkers in Patients With Adult‐Onset Still's Disease
Authors: Topping Joanne , Chang Leon , Nadat Fatima , Poulter James A. , Ibbotson Alice , Lara‐Reyna Samuel , Watson Christopher M. , Carter Clive , Pournara Linda P. , Zernicke Jan , Ross Rebecca L. , Cargo Catherine , Lyons Paul A. , Smith Kenneth G. C. , Del Galdo Francesco , Rech Jürgen , Fautrel Bruno , Feist Eugen , McDermott Michael F. , Savic Sinisa ,   the ImmunAID Consortium
Published: November 2024

ObjectiveAdult‐onset Still disease (AOSD) is a systemic autoinflammatory disorder (AID) of unknown etiology. Genetic studies have been limited. Here, we conducted detailed genetic and inflammatory biomarker analysis of a large cohort with AOSD to investigate the underlying pathology and identify novel targets for potential treatment.MethodsWe investigated AOSD cases (n = 60) for rare germline and somatic variants using whole exome sequencing with virtual gene panels. Transcriptome profiles were investigated by bulk RNA sequencing whole blood. Cytokine profiling was performed on an extended patient cohort (n = 106) alongside measurements of NLRP3 inflammasome activation using a custom assay and type I interferon (IFN) score using a novel method.ResultsWe observed higher than expected frequencies of rare germline variants associated with monogenic AIDs in AOSD cases (AOSD 38.4% vs healthy controls [HCs] 20.4%) and earlier onset of putative somatic variants associated with clonal hematopoiesis of indeterminate potential. Transcriptome profiling revealed a positive correlation between Still Activity Score and gene expression associated with the innate immune system. ASC/NLRP3 specks levels and type I IFN scores were significantly elevated in AOSD cases compared with HCs (P = 0.0001 and 0.0015, respectively), in addition to several cytokines: interleukin (IL)‐6 (P < 0.0001), IL‐10 (P < 0.0075), IL‐12p70 (P = 0.0005), IL‐18 (P < 0.0001), IL‐23 (P < 0.0001), IFN‐α2 (P = 0.0009), and IFNγ (P = 0.0002).ConclusionOur study shows considerable genetic complexity within AOSD and demonstrates the potential utility of the ASC/NLRP3 specks assay for disease stratification and targeted treatment. The enriched genetic variants identified may not by themselves be sufficient to cause disease, but may contribute to a polygenic model for AOSD.
Absorption, Fluorescence, and Two‐Photon Excitation Ability of 5‐o‐Tolyl‐11 (or 13)‐o‐tolylisoindolo[2,1‐a]quinolines Prepared by Ring‐Closing Metathesis and [2+3] Cycloaddition
Authors: Wada Yuki , Jang Kwangkyun , Ishii Hirokazu , Watakabe Yuki , Tsutsumi Motosuke , Sako Makoto , Takehara Tsunayoshi , Suzuki Takeyuki , Tsujino Hirofumi , Tsutsumi Yasuo , Nemoto Tomomi , Arisawa Mitsuhiro 
Published: November 2024

AbstractWe have successfully improved the fluorescence quantum yield of isoindolo[2,1‐a]quinoline derivatives by suppressing the rotation of the phenyl groups at positions 5 and 11 (or 13). Additionally, we found that the planarity of these phenyl groups at positions 5 and 11 (or 13) of isoindolo[2,1‐a]quinoline derivatives is crucial for two‐photon absorption properties.
Elucidating the anticancerous efficacy of genistein via modulating HPV (E7 and E6) oncogenes expression and apoptotic induction in cervical cancer cells
Authors: Pandey Pratibha , Ramniwas Seema , Pandey Shivam , Lakhanpal Sorabh , Ballal Suhas , Kumar Sanjay , Bhat Mahakshit , Sharma Shilpa , Kumar M. Ravi , Khan Fahad 
Published: November 2024

AbstractIn recent years, genistein has garnered increased interest for its ability to inhibit numerous deregulated targets associated with cancer progression and induction of programmed cell death and antiproliferative activities in human carcinoma cells. Cancer etiology is influenced via multiple disrupted signaling pathways. This study therefore directed toward investigating genistein efficacy in modulating mRNA expression levels of two crucial Human Pappiloma Virus (HPV) (E7 and E6) oncogenes for cancer treatment. Moreover, the inhibitory effects of genistein for HPV (E7 and E6) oncogenes in cervical carcinoma have not yet been reported. Current study investigated inhibitory potential of genistein in HPV (E7 and E6) oncogenes in HeLa cells. These oncogenes are known to deactivate many tumor suppressor proteins (p53 and pRB). Genistein therapy resulted in decreased cell proliferation and increased cell accumulation in the G (G0/G1) phase in HeLa cell lines. In addition, genistein therapy has resulted in the suppression of HPV (E7 and E6) gene expression and simultaneously increasing expression levels of p53 and pRB mRNA levels. As a consequence, there has been an activation of a series of caspases (3, 8, and 9), resulting in their cleavage. Consequently, our data suggests that genistein could be a powerful candidate for treating cervical cancer by targeting two important oncogenes involved in viral development. However, more in vitro research on primary cervical cancer cells is required to validate the clinically relevant efficacy of genistein against cervical cancer.
Designer Fluorescent Redoxmer Self‐Reports Side Reactions in Nonaqueous Redox Flow Batteries
Authors: Robertson Lily A. , Shkrob Ilya A. , Li Zhiguang , Agarwal Garvit , Yu Zhou , Assary Rajeev S. , Cheng Lei , Zhang Lu , Zhang Zhengcheng 
Published: November 2024

AbstractThe state of health (SOH) is a critical measure for evaluating and predicting performance of redox flow batteries (RFBs). However, diagnosing SOH of RFBs is often challenging due to the overwhelming complexity of the electrolytes and associated electrochemical reactions. Designing active molecules or redoxmers that can autonomously exhibit property changes upon specific stimuli may provide a viable way for early diagnosis of SOH. Herein, a dimerized redoxmer, DGL‐N‐CH3, was designed and synthesized by linking blue‐green fluorescent monomers through a diglycolamide linker. While DGL‐N‐CH3 still maintains similar electrochemical behavior and strong fluorescence, we observe a unique side reaction when cycling DGL‐N‐CH3 in H‐cells, which leads to a side product, NHCH3‐BzNSN via linker cleavage. Interestingly, NHCH3‐BzNSN also emits fluorescence but at a longer wavelength. By taking advantage of this unique fluorescent change that corresponds to the growth of NHCH3‐BzNSN, we successfully established the capacity decay of DGL‐N‐CH3 H‐cell cycling, exemplifying a proof‐of‐concept self‐reporting redoxmer design towards in situ SOH monitoring.
Urea‐Loaded PLGA Microspheres as Chemotaxis Stimulants for Helicobacter pylori
Authors: Shanmughan Prasanth , Subrahmaniyan Pravin , Bhatnagar Dhruv , Ranganathan Srinithi , Lele Pushkar P. 
Published: November 2024

ABSTRACTHelicobacter pylori cells undergo chemotaxis toward several small molecules, called chemo‐attractants, including urea produced by the epithelial cells of the stomach. The biophysical mechanisms of chemotaxis are not well understood in H. pylori. Here, we developed point sources of urea by encapsulating it in Poly(lactic‐co‐glycolic acid) or PLGA microbeads for H. pylori chemotaxis studies. Microscopy and Dynamic Light Scattering characterization indicated that the PLGA particles had an average diameter of < 0.8 μm. The particles were relatively stable and had a net negative surface charge. Absorbance measurements indicated that the beads released ~70% of the urea over a 2‐week period, with most of the release occurring within the first 24‐h period. Varying pH (2.0–7.0) had little effect on the rate of urea release. A diffusion model predicted that such beads could generate sufficient urea gradients to chemotactically attract H. pylori cells. Single‐bead single‐cell chemotaxis assays confirmed the predictions, revealing that H. pylori continued to be attracted to beads even after most of the urea had been released in the first 24 h. Our work highlights a novel use of PLGA microbeads as delivery vehicles for stimulating a chemotaxis response in H. pylori, with potential applications in bacterial eradication strategies.
Association of depression with longitudinal changes in brain structure across the lifespan: A mendelian randomization study
Authors: Chen Zheng , Sui Guanghong , Yang Caixia , Lv Zongshun , Wang Feng 
Published: November 2024

AbstractUnderstanding the impact of depression on brain aging benefits the prognosis of this disease and of the risk that other age‐related brain disorders will develop in the same population. The aim of the present study was to explore the genetic effect of depression on longitudinal changes in brain structure throughout the lifespan using a Mendelian randomization approach. Summary data from a genome‐wide association study of 195,321 to 377,277 participants in the FinnGen consortium were used to predict depression, anxiety disorders, mood disorders, and antidepressant use genetically. Data from 15,640 participants in the ENIGMA consortium were included to predict changes in 15 brain structures throughout the lifespan. The causal relationship between these depressive traits and the brain structure parameters was assessed by two‐sample Mendelian randomization (including inverse‐variance weighted). Sensitivity analyses were conducted for quality control. Depression slowed the decrease of cortical gray matter volume significantly throughout the lifespan (p = 0.001). Depression, anxiety, and mood disorders nominally decreased the rates of change of volume in the cerebellum gray matter, lateral ventricles, and cortical gray matter throughout the lifespan (p = 0.048, p = 0.021, p = 0.038, respectively). Antidepressants did not affect these rates of change significantly (p > 0.05). Sensitivity analyses confirmed the reliability of this study. Depression and its main symptoms have a slight effect on longitudinal changes in a few brain structures throughout the lifespan at the genetic level. These findings do not support the notion that depression affects macro‐aging in the brain crucially.