bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric appendectomy in developing countries
Authors: Akkary Rezkalla , Zeidan Smart , Matta Reva , Lakis Chantal , Diab Nabil 
Published: July 2019

Introduction:
A review of the English literature indicates the faint superiority of laparoscopic (LA) over open appendectomy (OA) in the pediatric population; however, a developing-country's experience in the field is not available yet. This study presents our experience in LA versus OA over the last 7 years in one university hospital in Lebanon and compares our results to the international ones.

Method:
A single center retrospective study was done including all patients aged less than 15 years who underwent appendectomy. A description of each operative technique is presented. Patients' characteristics, intraoperative finding, operative timing (OT), length of stay (LOS) and short term postoperative complications including surgical site infection (SSI) rate, intra-abdominal abscess formation (IAA) rate and reoperation rate were all studied. Statistical analysis was done using Chi-square or Fisher's exact test, as for continuous, Student's t test was used or one-way ANOVA in case of more than 2 categories.

Result:
Appendectomy was performed in 84 patients. 52 patients underwent OA through a Rocky Davis incision, and 32 patients underwent a LA. We found an advantage of LA over OA in reducing SSI, otherwise both approaches were similar.

Conclusion:
In accordance with international results, in our experience, LA is superior to OA only with regards to SSI.
UNCOUNTABLE TREES AND COHEN -REALS
Authors: LAGUZZI GIORGIO 
Published: July 2019

AbstractWe investigate some versions of amoeba for tree-forcings in the generalized Cantor and Baire spaces. This answers [10, Question 3.20] and generalizes a line of research that in the standard case has been studied in [11], [13], and [7]. Moreover, we also answer questions posed in [3] by Friedman, Khomskii, and Kulikov, about the relationships between regularity properties at uncountable cardinals. We show ${\bf{\Sigma }}_1^1$-counterexamples to some regularity properties related to trees without club splitting. In particular we prove a strong relationship between the Ramsey and the Baire properties, in slight contrast with the standard case.
Thermal Decomposition of Lead White for Radiocarbon Dating of Paintings
Authors: Beck Lucile , Messager Cyrielle , Coelho Stéphanie , Caffy Ingrid , Delqué-Količ Emmanuelle , Perron Marion , Mussard Solène , Dumoulin Jean-Pascal , Moreau Christophe , Gonzalez Victor , Foy Eddy , Miserque Frédéric , Bonnot-Diconne Céline 
Published: July 2019

ABSTRACTLead carbonates were used as cosmetic and pigment since Antiquity. The pigment, known as lead white, was generally composed of cerussite and hydrocerussite. Unlike most ancient pigments, lead white was obtained by a synthetic route involving metallic lead, vinegar and organic matter. Fermentation of organic matter produces heat and CO2 emission, leading to the formation of carbonates. As lead white is formed by trapping CO2, radiocarbon (14C) dating can thus be considered. We have developed a protocol to prepare lead white. We selected modern pigments for the experiment implementation and ancient cosmetic and paintings for dating. After characterization of the samples by XRD, thermal decomposition of cerussite at various temperatures was explored in order to select the appropriate conditions for painting samples. CO2 extraction yield, SEM and XPS were used to characterize the process. Thermal decomposition at 400°C was successfully applied to mixtures of lead white with other paint components (oil as binder, calcite as filler/extender) and to historical samples. We obtained radiocarbon measurements in agreement with the expected dates, demonstrating that thermal decomposition at 400°C is efficient for a selective decomposition of lead white and that paintings can be directly 14C-dated by dating lead white pigment.
Why Did the Nazis Sterilize the Blind? Genetics and the Shaping of the Sterilization Law of 1933
Authors: Teicher Amir 
Published: July 2019

AbstractThe introduction of blindness into the Sterilization Law passed by the Nazis in July 1933, was exceptional, even by the standards of the time. Prior sterilization bills had focused on mental and nervous disorders, and they almost always excluded blindness as a category. The wish to sterilize the blind cannot be explained solely as stemming from the eugenic or economic threat that they allegedly posed to German society; such threats were acknowledged to be marginal, and they paled in comparison to the perceived menace attributed to the so-called feeble-minded and mentally ill. What made blindness of special significance for Nazi lawmakers was its disciplinary status among geneticists as an indisputable demonstration of the validity of the laws of heredity to human maladies. Together with two additional disease categories—deafness and Huntington's chorea—blindness provided Nazi legislators with scientific legitimization that helped pave the way for the sterilization of the mentally ill. For the blind, it was therefore not the fanaticism of the Nazis but rather their aspiration to ground their policy in biological teaching that ultimately proved fateful.
Factors influencing physical activity participation among older people with low activity levels
Authors: Rai Rajni , Jongenelis Michelle I. , Jackson Ben , Newton Robert U. , Pettigrew Simone 
Published: July 2019

AbstractDespite the well-documented health benefits of physical activity in older adults, participation levels remain low. With rapid global population ageing, intensive efforts are needed to encourage higher levels of participation to ameliorate the negative effects of physical inactivity for older individuals and society as a whole. The aim of this qualitative study was to inform future physical activity promotion interventions by examining factors contributing to low activity levels among older people undertaking less than half the recommended level of moderate-to-vigorous physical activity (MVPA). Semi-structured interviews were conducted with 102 (65% female) community-dwelling Western Australians aged 60+ years (mean = 71.52, standard deviation = 6.26) who engaged in ⩽75 minutes of MVPA per week as measured by accelerometers. Several modifiable and unmodifiable barriers were identified, of which poor health featured most prominently. Lifetime physical inactivity, caring duties, low motivation, misperceptions of physical activity and ageing, and a lack of affordable and attractive options were the other barriers identified. The results suggest that strategies are needed to raise awareness of current physical activity guidelines, normalise engagement in MVPA throughout the lifespan, develop initiatives to motivate participation, improve the availability of affordable physical activity programmes that are attractive to this population segment, and facilitate participation among those with intensive caring responsibilities.
TRADING IN AN EMERGING MARKET: E. JOHNSTON & CO AND THE BRAZILIAN COFFEE TRADE 1840-1880
Authors: Guimarães Carlos Gabriel , Greenhill Robert 
Published: July 2019

ABSTRACTThe article analyses the development of the coffee export business of the British company Edward Johnston & Co. in the years 1840-1880. Established in 1842 in the city of Rio de Janeiro, the firm's senior partner was the English merchant Edward Johnston. The departure of partners and the crisis of 1847 made Edward Johnston reorganise the firm in Brazil. In the 1850s, the company established itself as a family business based in Liverpool and then in London in the 1860s. The expansion of the coffee market in the United States made Edward Johnston create a network of firms which consolidated the company as a major exporter of Brazilian coffee by the late 1870s.
Considerations in assessing pragmatic appropriateness in spoken language
Authors: Cohen Andrew D. 
Published: July 2019

AbstractThis paper is a revised version of a plenary prompted by the upsurge of interest in the role of pragmatics in teaching, learning, and assessment, and has as its purpose to take a fresh look at recent developments in the assessment of target-language (TL) pragmatics in spoken language. The first issue considered is the question of whether to attempt to assess pragmatics as it unfolds naturally in interactions, and if so, how to do it. Next, micro-level and macro-level factors in the assessment of TL pragmatics are considered. Third, a close look is given to the specific elements of TL pragmatics to assess. Fourth, there is attention to the matter of which instruments are most appropriate for collecting the desired data in the given context. Fifth, issues relating to data analysis are discussed. Finally, matters pertaining to the assessment of classroom instruction are looked at. Recommendations are given as to potentially viable directions for dealing with these issues both in terms of research studies and for assessment of classroom instruction.
Using enhanced regression calibration to combine dietary intake estimates from 24 h recall and FFQ reduces bias in diet–disease associations
Authors: Looman Moniek , Boshuizen Hendriek C , Feskens Edith JM , Geelen Anouk 
Published: July 2019

AbstractObjective:To illustrate the impact of combining 24 h recall (24hR) and FFQ estimates using regression calibration (RC) and enhanced regression calibration (ERC) on diet–disease associations.Setting:Wageningen area, the Netherlands, 2011–2013.Design:Five approaches for obtaining self-reported dietary intake estimates of protein and K were compared: (i) uncorrected FFQ intakes (FFQ); (ii) uncorrected average of two 24hR ($\overline {\rm R}$); (iii) average of FFQ and$\overline {\rm R}$(${\overline {\rm F}}\,\overline {\rm R}}$); (iv) RC from regression of 24hRv. FFQ; and (v) ERC by adding individual random effects to the RC approach. Empirical attenuation factors (AF) were derived by regression of urinary biomarker measurementsv. the resulting intake estimates.Participants:Data of 236 individuals collected within the National Dietary Assessment Reference Database.Results:Both FFQ and 24hR dietary intake estimates were measured with substantial error. Using statistical techniques to correct for measurement error (i.e. RC and ERC) reduced bias in diet–disease associations as indicated by their AF approaching 1 (RC 1·14, ERC 0·95 for protein; RC 1·28, ERC 1·34 for K). The largersdand narrower 95% CI of AF obtained with ERC compared with RC indicated that using ERC has more power than using RC. However, the difference in AF between RC and ERC was not statistically significant, indicating no significantly better de-attenuation by using ERC compared with RC. AF larger than 1, observed for the ERC for K, indicated possible overcorrection.Conclusions:Our study highlights the potential of combining FFQ and 24hR data. Using RC and ERC resulted in less biased associations for protein and K.
The Legitimacy of Dam Development in International Watercourses: A Case Study of the Harirud River Basin
Authors: Nagheeby Mohsen , Piri D. Mehdi , Faure Michael 
Published: July 2019

AbstractThis article examines the international legitimacy of unilateral dam development in an international watercourse from the perspective of international water law. Drawing upon technical analysis over the Harirud River Basin, the article discusses probable negative impacts of unilateral dam development in Afghanistan on downstream Iran and Turkmenistan. Competing claims are analyzed to assess emerging transboundary damage under customary international water law. Applying these insights to the case study, this article explores how legal norms and principles can contribute to transboundary water cooperation. It investigates how equitable and reasonable utilization, as required by the United Nations Watercourse Convention, could be reached and whether current activities are in conformity with international norms. Based on this analysis and in the light of international customary law, the article questions the compatibility of unilateral control and capture of water resources in Afghanistan, particularly through the Salma Dam, with ‘equitable and reasonable utilization’ and ‘no significant harm’ rules. The article also argues that building the Salma Dam results in significant transboundary harm to downstream states. Hence, such harm could be considered as significant transboundary damage. Conclusions point to an understanding of water law as a form of institutional guidance in order to provide a transparent setting for transboundary water cooperation among riparian states.
Unsustainable groundwater use for global food production and related international trade
Authors: Dalin Carole , Taniguchi Makoto , Green Timothy R. 
Published: July 2019

Non-technical summary
Most of the water humans consume is for agriculture. Rapidly increasing water demand has led to overexploitation of water resources in many important food-producing regions. In particular, growing groundwater-based irrigation causes potentially damaging depletion. Food systems are increasingly globalized, leading to large export-oriented production. Much research has focused on quantifying the amount of water resources embedded in traded products, but less attention has been given to the role of groundwater use and the related sustainability of agriculture globally. We assess current knowledge of virtual water trade in light of groundwater use and sustainability and highlight remaining challenges in this field.
Atmospheric Water Demand Dominates Daily Variations in Water Use Efficiency in Alpine Meadows, Northeastern Tibetan Plateau
Authors: Wu Xiuchen , Li Xiaoyan , Chen Yunhao , Bai Yan , Tong Yaqin , Wang Pei , Liu Hongyan , Wang Mengjie , Shi Fangzhong , Zhang Cicheng , Huang Yongmei , Ma Yujun , Hu Xia , Shi Chunming 
Published: July 2019

AbstractEcosystem water use efficiency (WUE) acts as an integrated functional indicator for understanding land‐atmosphere interactions. The temporal patterns in the daily variations of WUE and their underlying drivers during different seasons in alpine meadow ecosystems, which are particularly vulnerable to changing climate, still remain poorly understood in spite of increasing efforts. In this study, we investigated the potential divergence in the response of WUE to climatic and biological drivers during different seasons at two alpine meadow ecosystems in the northeastern Tibetan Plateau using continuous eddy‐covariance measurements of carbon and water fluxes between 2013 and 2015. We found that variations in CO2 concentration exert significantly positive effects on variations in WUE in spring, but not in summer and autumn. Notably, vapor pressure deficit (VPD) overrode other factors playing a dominant role in regulating daily variations in WUE during all seasons in these alpine meadow ecosystems. Variations in VPD explained 29.5 to 52.3% of the variance in WUE between different seasons. We further showed that carbon gain and water loss processes responded divergently to different drivers; higher VPD significantly increased ecosystem evapotranspiration; whereas, variations in soil moisture and leaf area index significantly and positively affected gross primary productivity. Our findings highlighted the increasing importance of atmospheric drought in shaping land‐atmosphere interactions in alpine meadow ecosystems, particularly in a warming climate.
Mass Transport and Structural Properties of Binary Liquid Iron Alloys at High Pressure
Authors: Posner Esther S. , Steinle‐Neumann Gerd 
Published: July 2019

AbstractWe determine mass transport and structural properties of binary liquid iron alloys over a wide density (5.055–11.735 g·cm−3) and temperature range (2,500–6,500 K) using first‐principles molecular dynamics. Compositions consist of 96 at% Fe and 4 at% ϕ, where ϕ = H, C, N, O, Mg, Si, S, or Ni. Self‐diffusion coefficients (D) of Fe and ϕ range from 3.5·10−9 to 1.9·10−7 m2·s−1. Results show a relation between mean atomic radius and diffusivity ratio for the alloying element and iron: Si and Ni are “iron‐like” with similar atomic radii and D compared with those of Fe; H, C, N, O, and S are “small non‐iron‐like” with smaller atomic radii and larger D; and Mg transitions from “large non‐iron‐like” with a larger atomic radius and smaller D at low density to iron‐like under conditions of the Earth's core. The effect of pressure on D for C, N, and O is negligible for densities below ~8 g·cm−3, accompanied by an increase in average coordination numbers to ~6, and an increase in mean atomic radii. For densities above ~8 g·cm−3, diffusivities and atomic radii of these elements decrease monotonically with pressure, which is typical for the iron‐like alloying elements as well as for H, Mg, and S over the whole compression range. While atomic radius ratios move toward unity with compression, diffusivity ratios for the alloying element relative to iron tend to increase for the “non‐iron‐like” elements with density.
Large Spatial and Temporal Variability of Carbon Dioxide and Methane in a Eutrophic Lake
Authors: Loken Luke C. , Crawford John T. , Schramm Paul J. , Stadler Philipp , Desai Ankur R. , Stanley Emily H. 
Published: July 2019

AbstractLakes are conduits of greenhouse gases to the atmosphere; however, most efflux estimates for individual lakes are based on extrapolations from a limited number of locations. Within‐lake variability in carbon dioxide (CO2) and methane (CH4) arises from differences in water sources, mixing, atmospheric exchange, and biogeochemical transformations, all of which vary across multiple temporal and spatial scales. We asked, how variable are CO2 and CH4 across the surface of a single lake, how do spatial patterns change seasonally, and how well does the typical sampling location represent the entire lake surface? During the 2016 ice‐free period, we mapped surface water concentrations of CO2 and CH4 approximately weekly in Lake Mendota (USA) and modeled diffusive gas exchange. During stratification, CO2 was generally lower than atmospheric saturation (mean 19.81 μM) and relatively homogenous (mean coefficient of variation 0.12), whereas CH4 was routinely extremely supersaturated (mean 0.29 μM) with greater spatial heterogeneity (mean coefficient of variation 0.65). During fall mixis, concentrations of both gases increased and became more spatially variable, but their spatial arrangements differed. In this system, samples collected from the lake center reasonably well represented the spatially weighted mean CO2 concentration but overestimated annual CO2 efflux by 21%. For CH4, the lake center underestimated annual diffusive efflux by only 8.6% but poorly represented lakewide concentrations and fluxes on any given day. Upscaling from a single site to the whole lake requires consideration of spatial variation to assess lakewide carbon dynamics due to heterogeneity in within‐lake processing, transport to the lake surface, and exchange with the atmosphere.
High cloud coverage over melted areas dominates the impact of clouds on the albedo feedback in the Arctic
Authors: He Min , Hu Yongxiang , Chen Nan , Wang Donghai , Huang Jianping , Stamnes Knut 
Published: July 2019

AbstractWarming in the Arctic is larger than the global average. A primary reason for this Arctic Amplification is the albedo feedback. The contrasting albedo of sea ice and dark melted surface areas is the key component of albedo feedback. Cloud coverage over the changing surface and the response of the clouds to the changing surface conditions will modify the change in planetary albedo when sea ice melts. Space-based lidar measurements provide a unique opportunity for cloud measurements in the Arctic. The response of clouds to the changing sea ice concentration was directly observed. Based on CALIPSO satellite observations of cloud properties, this study found that cloud coverage in ice-free regions in the Arctic linearly increased with the area of ice-free water during the melt seasons in the past 10 years, while sea ice coverage varies significantly year-to-year. The observations suggest that when sea-ice retreats, cloud fraction of the ice-free region remains fixed at nearly 81%. The high cloud coverage over melted areas significantly reduces the albedo feedback. These results indicate that space-based lidar cloud and surface observations of the Arctic can help constrain and improve climate models.
Aging effects on the mechanical energy transfer through the lower extremity joints during the swing phase of level walking
Authors: Chen Hung-Bin , Chang Liang-Wey , Cheng Chih-Hsiu 
Published: July 2019

AbstractAge-related changes of gait performance have been evidenced by the altered kinetic coordination of the lower extremity. However, a systematic approach to explore the gait control in terms of the mechanical energy transfer across multiple segments throughout the gait phases is still not well documented. Ten healthy elderly and ten young adults were asked to walk along a 10-meter walkway at the self-selected and fast walking speeds. The visualized energy flow model of the swing leg was established and the factor analysis was then applied to extract the high-dimensional energy flow characteristics of the swing leg. The results showed that the young adults have similar energy flow characteristics of the swing leg for both fast and self-selected walking speeds, while the elderly showed an opposite energy flow pattern especially at the fast walking speed. The hip power and the knee power were also found to mainly correspond to the swing acceleration and deceleration, respectively. This study demonstrated a valuable tool to explore the change of the gait characteristics in the elderly and could help to facilitate the understanding of the neuromuscular adaptation due to aging.
A subset of topologically associating domains fold into mesoscale core-periphery networks
Authors: Huang Harvey , Chen Sunnia T. , Titus Katelyn R. , Emerson Daniel J. , Bassett Danielle S. , Phillips-Cremins Jennifer E. 
Published: July 2019

AbstractMammalian genomes are folded into a hierarchy of compartments, topologically associating domains (TADs), subTADs, and long-range looping interactions. The higher-order folding patterns of chromatin contacts within TADs and how they localize to disease-associated single nucleotide variants (daSNVs) remains an open area of investigation. Here, we analyze high-resolution Hi-C data with graph theory to understand possible mesoscale network architecture within chromatin domains. We identify a subset of TADs exhibiting strong core-periphery mesoscale structure in embryonic stem cells, neural progenitor cells, and cortical neurons. Hyper-connected core nodes co-localize with genomic segments engaged in multiple looping interactions and enriched for occupancy of the architectural protein CCCTC binding protein (CTCF). CTCF knockdown and in silico deletion of CTCF-bound core nodes disrupts core-periphery structure, whereas in silico mutation of cell type-specific enhancer or gene nodes has a negligible effect. Importantly, neuropsychiatric daSNVs are significantly more likely to localize with TADs folded into core-periphery networks compared to domains devoid of such structure. Together, our results reveal that a subset of TADs encompasses looping interactions connected into a core-periphery mesoscale network. We hypothesize that daSNVs in the periphery of genome folding networks might preserve global nuclear architecture but cause local topological and functional disruptions contributing to human disease. By contrast, daSNVs co-localized with hyper-connected core nodes might cause severe topological and functional disruptions. Overall, these findings shed new light into the mesoscale network structure of fine scale genome folding within chromatin domains and its link to common genetic variants in human disease.