bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initiation of Meiotic Development Is Controlled by Three Post-transcriptional Pathways inCaenorhabditis elegans
Authors: Mohammad Ariz , Vanden Broek Kara , Wang Christopher , Daryabeigi Anahita , Jantsch Verena , Hansen Dave , Schedl Tim 
Published: June 2018

AbstractA major transition in germ cell development is the switch from mitotic cell cycling to entry into the meiotic developmental pathway. Mohammad et al. report that the SCFPROM-1 substrate-specific E3 ubiquitin ligase complex is a new...A major event in germline development is the transition from stem/progenitor cells to entry into meiosis and gametogenesis. This transition requires downregulation of mitotic cell cycle activity and upregulation of processes associated with meiosis. We identify the Caenorhabditis elegans SCFPROM-1 E3 ubiquitin-ligase complex as functioning to downregulate mitotic cell cycle protein levels including cyclin E, WAPL-1, and KNL-2 at meiotic entry and, independently, promoting homologous chromosome pairing as a positive regulator of the CHK-2 kinase. SCFPROM-1 is thus a novel regulator of meiotic entry, coordinating downregulation of mitotic cell cycle proteins and promoting homolog pairing. We further show that SCFPROM-1 functions redundantly, in parallel to the previously described GLD-1 and GLD-2 meiotic entry pathways, downstream of and inhibited by GLP-1 Notch signaling, which specifies the stem cell fate. Accordingly, C. elegans employs three post-transcriptional pathways, SCFPROM-1-mediated protein degradation, GLD-1-mediated translational repression, and GLD-2-mediated translational activation, to control and coordinate the initiation of meiotic development.
Conceptualizing gambling disorder with the process model of emotion regulation
Authors: Rogier Guyonne , Velotti Patrizia 
Published: June 2018

Introduction
Nowadays, gambling disorder (GD) is a worldwide health issue and there is a growing need to both improve our understanding of this disorder and to tailor specific interventions for its treatment. Moreover, theoretical models and preliminary empirical results suggest that difficulty in regulating emotional states might be involved in GD. However, literature describing clinical and theoretical aspects of emotional dysregulation among pathological gamblers (PGs) shows a lack of systematic description.

Objectives
We aimed to provide, within an exhaustive theoretical framework of emotion regulation (ER) processing, empirical evidence supporting a conceptual model of GD as an ER affliction.

Methods
We commented on empirical evidence on the relationship between ER and GD in the light of two main conceptual models of emotion (dys)regulation.

Results
The results suggest there are actual deficits of ER processing among PGs, manifesting themselves through different ways and in different steps of the ER timeline. In addition, dysregulation of positive emotions may play a central role in GD. From a clinical point of view, we pointed out that deficits in ER might be multiple in nature and an assessment for GD should be accurate to identify the specific components accounting for the development and maintenance of the disorder. It should also orientate the clinician in selecting therapeutic objectives.

Conclusions
The nature of emotional states that are difficult to regulate might account for the GD severity and indicate the subtype of PGs the patient belongs to. Treatment programs should be tailored on the specificity of PGs.
Semmelweis – egy gondolkodó ember. Tudománytörténeti tanulságok
Authors: Gazda István 
Published: June 2018

Abstract: In this article we examine why Semmelweis’s seemingly simple, logical and practical discovery was categorically dismissed by the majority of his contemporaries, and why even many years after his death it was accepted with such reservation. We invoke wherever possible Semmelweis’s own words citing from the series of articles appearing in the ‘Orvosi Hetilap’ [Hungarian Medical Weekly Journal] published in 1858 in Hungary, and also from the German language summary of the Journal published in 1860. We came to the conclusion that although Semmelweis did everything in his power to show the causal relationship between the development of puerperal fever (childbed fever) and some infectious substance on the hands of examining doctors and medical students, this was not convincing enough. The predominant theory at the time held that infection was caused by miasma transmitted in the air and therefore stubbornly precluded any notion of infectious matter physically transmitted on unclean hands. We also concluded that the causal sequence observed by Semmelweis was missing an essential empirical element: visual proof of the infectious agent he correctly postulated as physically transmitted. Visually demonstrating the presence of the infectious agent by means of a microscope would have made his case. This finally did occur but only two years after Semmelweis’s death. Had the renowned Hungarian obstetrician realized the significance of taking advantage of the opportunity afforded by Dávid Gruby who was conducting experiments in the same town, a more convincing argument could have been made for his theory. In the 1840s and 1850s, Dávid Gruby was experimenting with various microscopic techniques and their application with success in Vienna before continuing his work in France. Gruby’s work, especially that of microscopic observations of tissues, received international acceptance. Therefore, the involvement of Gruby and his work with microscopes to support Semmelweis’s observations would most probably have forestalled much of the criticism and rejection his theory was initially awarded (among which perhaps Virchow’s rejection proved the most damaging). Had Semmelweis utilized microscopic techniques, he would have been celebrated among the first to discover bacterial pathogens, contributing to the development of the currently predominant germ theory. Failure to utilize the microscope was the root cause leading to the tragedy of Semmelweis’s rejection by the medical establishment of the time. Despite the increasing numbers of scientists utilizing the microscope at the University of Pest, offered to corroborate his daims with microscopic observations. Efforts have been made have since been to rehabilitate him as the key figure who not only discovered the method of transmission of infectious disease, but also implemented measures of prevention. Elevating him among the ranks of the ten greatest doctors who ever lived is certainly recognition due, but sadly denied to him in his lifetime. Orv Hetil. 2018; 159(26): 1055–1064.
Hindu Düşünür Dayananda Sarasvati’nin Kur’ân’a Yönelik Eleştirileri
Authors: KUTLUTÜRK Cemil 
Published: June 2018

Farklı din mensuplarının birbirlerine karşı yazdıkları
savunma veya eleştiri içeren metinlerden oluşan reddiye geleneği, Dinler
Tarihi için önemli
bir çalışma
alanıdır. Ülkemizde
Yahudi-Hıristiyan-Müslüman
reddiye geleneğini konu alan çok kıymetli çalışmalar
mevcuttur. Fakat kökleri İslâm’ın ilk
yıllarına
kadar uzanan Hindular ile Müslümanlar
arasındaki
ilişkileri ve her iki dinî geleneğe mensup bireylerin birbirlerine yönelik
bakışını konu
edinen çalışma
yok denecek kadar azdır. Bu alana katkı sunmak amacıyla kaleme alınan bu yazıda, fikirleriyle modern dönem Hindu düşüncesine
yön vermiş
ve Arya Samac hareketinin kuruculuğunu üstlenmiş olan Dayananda Sarasvati’nin,
Kur’ân-ı Kerim’in üslubuna
ve muhtevasına
dair eleştirileri incelenmiştir. Konu daha ziyade onun Satyarth Prakaş (Hakikat Nuru)
adlı
eserine dayanılarak
ele alınmıştır.
Böylece Hindu-Müslüman reddiye geleneği hakkında okuyuculara bilgi verilmiş ve bu alanda yeni
çalışmaların yapılması
hususunda birikimli araştırmacıların teşvik edilmesi amaçlanmıştır
Strength Abilities: Features of Their Development in Girls of Middle School Age
Authors: Veremeenko V. Yu. 
Published: June 2018

The study objective is to determine the dynamics of strength preparedness of middle school girls. Materials and methods. The participants in the study were 6th grade girls (n=20), 7th grade girls (n = 27), 8th grade girls (n = 30). The study used analysis and collation of scientific and methodological literature, pedagogical testing and methods of mathematical statistics for processing research results. The IBM SPSS 23 statistical analysis software was used to process the study materials. The study calculated the following parameters: arithmetic mean of the value (X); standard square deviation (s), mean difference. The probability of difference in statistical indicators was estimated using the Student’s t-test. Results. The analysis of the test results of the 6th-7th grade girls showed statistically significant differences in the set of tests (p<0.05). For the 7th grade girls, the largest increase was observed in the strength indicators of shoulder muscles, abdominal and back muscles, strength indurance of leg muscles. For the 6th-8th grade girls, statistically significant differences were observed in the strength and strength endurance indicators of shoulder muscles, abdominal and back muscles, leg muscles, speed qualities (p<0.05). The study did not observe any statistically significant differences in the set of tests (p>0.05) for the 7th-8th grade girls, there was only an increase in the strength endurance indicators of leg and back muscles. Statistically significant differences were observed in the frequency of arm movements test (p<0.001). Conclusions. The girls of middle school age demonstrate a positive dynamics in the development of motor preparedness. The largest increase is observed in the strength and strength endurance indicators of shoulder, abdominal, back, and leg muscles.
Movement Coordination: Identification of Age-Related Dynamics of its Development in Girls Aged 11-13
Authors: Ivashchenko O. V. , Khudolii O. M. , Iermakov S. S. , Prykhodko V. V. , Cieslicka M. 
Published: June 2018

The study objective is to determine the possibility of identifying the state of coordination abilities development in girls aged 11-13 using the methodology of multidimensional statistics.
Materials and methods. The study involved girls aged 11 (n=20), 12 (n=23), 13 (n=19). To evaluate motor preparedness, the study recorded the results of motor tests, body height and weight. The IBM SPSS 20 statistical analysis software was used to process the study materials. A discriminant analysis was performed.
Results. To identify the level of coordination abilities development in girls aged 11, 12 and 13, the following tests can be used: test 4 “Pull-ups (number of times)”, test 2 “Standing long jump (cm)”, test 6 “Evaluation of the sense of movement speed in sprinting”, and test 9 “Static equilibrium evaluation by E. Ya. Bondarevsky’s method”, which characterize relative and speed strength, the sense of running speed and vestibular stability.
To identify the state of coordination abilities development in girls aged 12-13, the following tests can be used: test 12 “Rhythmic hand tapping”, test 13 “Rhythmic movements of upper and lower limbs”, test 5 “Sit-ups in 30 seconds”, test 7 “Evaluation of the ability to differentiate movement speed (reproduction accuracy of running speed at 80% intensity of maximum)”, which characterize the movement coordination of different parts of the body, strength endurance of abdominal muscles, and the evaluation of the ability to differentiate movement speed.
Conclusions. A discriminant analysis made it possible to determine informative indicators for a comprehensive control of coordination abilities development in girls aged 11-13; to answer the questions as to how the states of coordination abilities development in girls aged 11, 12 and 13 significantly differ; what motor tests most substantially influence the differentiation of classes; what class the object belongs to based on the values of discriminant variables.
Kabuk ve ambrosya böceklerine karşı alternatif mücadele olarak entomopatojen fungusların kullanımı
Authors: KUSHİYEV Rahman , TUNCER Celal , ERPER İsmail 
Published: June 2018

Kabuk ve ambrosya böcekleri (Coleoptera: Curculionidae: Scolytinae ve Platypodinae) dünyanın birçok ülkesinde orman ve meyve ağaçlarını ciddi şekilde tehdit eden önemli zararlılardır. Bu böceklerin hayatlarının uzun bir dönemini ağaçların içerisinde geçirmeleri, sadece ergin dönemde ağaçları terk etmeleri, birden fazla türün aynı bitki türü üzerinde zararlı olabilmesi ve bu türlerin ergin çıkış dönemlerinin uzun bir zaman dilimine yayılıyor olması gibi nedenlerle kimyasal mücadeleleri oldukça zor olmaktadır. Bu nedenle, söz konusu mücadele birden fazla kimyasal uygulama yapılmasını gerektirmektedir. Diğer yandan kimyasal mücadelenin bilinen olumsuzlukları nedeniyle bu zararlılarla mücadelede alternatif yaklaşımlara ihtiyaç duyulmaktadır. Bu açıdan entomopatojen funguslar kabuk ve ambrosya böcekleri gibi ağaç dokuları içinde yaşayan zararlıların mücadelesinde oldukça uygun biyolojik mücadele etmenleridir. Entomopatojen funguslar sadece ergin ölümlerine neden olmakla kalmamakta, aynı zamanda bu böceklerin galerileri içerisinde horizontal ve vertikal yolla taşınarak böcek popülasyonunu önemli derecede düşürmektedir. Ayrıca, entomopatojen funguslar kabuk ve ambrosya böcekleri üzerinde repellent (kaçırıcı) etkilere de sahiptir. Diğer yandan bu fungusların kitle üretimleri ve preparat haline getirilmeleri diğer birçok biyolojik etmene göre daha kolaydır. Halen bazı zararlı böceklerin biyolojik mücadelesi için ruhsat almış entomopatojen fungus preparatları piyasada mevcuttur. Ayrıca doğal koşullar altında yapılan çalışmalarda kabuk ve ambrosya böcekleri üzerinde etkili olan entomopatojen funguslara sıkça rastlanmaktadır. Sonuç olarak, bu çalışmada entomopatojen fungusların kabuk ve ambrosya böcekleriyle biyolojik mücadelede alternatif olarak kullanılabilme potansiyelleri değerlendirilmiştir.
Explore the Development and Application of Electrical Automation Control Systems
Authors: Niu Zhishan , Zhao Yanfeng , Hu Junjun , Wang Deyong , Dong Lin , Wang Lijun 
Published: June 2018

The development of electrical automation engineering control system is the foundation of modern industrial development in China, and also an important embodiment of the rapid development of modern technology. The application of electric automation technology can not only improve work efficiency, but also reduce enterprise cost. Based on this, the current situation and development trend of electrical automation engineering control system are studied for reference by relevant staff.
Un comerciante navarro dueño de los bosques de la costa oriental de Yucatán: Faustino Martínez (1889-1909)
Authors: Rangel Gonzalez Edgar Joel 
Published: June 2018

A través del recuento histórico sobre la presencia del empresariado en la explotación forestal en los bosques de la costa oriental de Yucatán, se reconstruye la figura de Faustino Martínez, hombre de negocios que representa a la oligarquía económica mexicana del porfiriato, y cuyo perfil empresarial le permitió emprender negocios y acciones para aprovechar las concesiones en el oriente de la península yucateca. El acceso que tuvo a las altas esferas, económica y política, nos permite conocer la trascendencia de este español a partir de sus nexos y negocios en la región, lo que le permitió obtener vastas propiedades, autorizaciones forestales, atraer la fuerza de trabajo y establecer una economía de extracción para coadyuvar a la constitución del territorio federal de Quintana Roo.
Interjeksi dalam Bahasa Arab
Authors: Ramadhani Sahara 
Published: June 2018

AbstractInterjection is the words used to show expressions spontaneously. Each language has different forms of interjection. This study aims to provide a comprehensive overview of the intermediate form in Arabic. The data used in this study is written data in the form of Arabic novels and drama script. The data is obtained by the attentive observation method. The basic technique used is tapping technique. The advanced technique is by using the note technique. The methods used for the data analysis are distribution and contextual method. The results of the analysis show that based on the form of Arabic interjections, it can be grouped into primary forms, secondary forms, phrase form, and clause form. AbstrakInterjeksi merupakan kata-kata yang digunakan untuk menunjukkan ekspresi secara spontan. Setiap bahasa memiliki bentuk interjeksi yang berbeda-beda. Penelitian ini bertujuan untuk memberikan gambaran secara menyeluruh mengenai bentuk interjeksi dalam bahasa Arab. Data yang dipergunakan dalam penelitian ini adalah data tertulis yang berupa novel dan naskah drama Arab. Data tersebut diperoleh dengan metode simak. Teknik dasar yang digunakan adalah teknik sadap. Adapun teknik lanjutannya menggunakan teknik catat. Metode yang dipergunakan untuk menganalisis data adalah metode distribusi dan metode kontekstual. Hasil analisis menunjukkan bahwa berdasarkan bentuknya interjeksi bahasa Arab dapat dikelompokkan menjadi bentuk primer, bentuk sekunder, bentuk frasa, dan bentuk klausa.
Interactions Between Environmental Factors and Zinc Concentrations in Porewater and Roots of Rhizophora sp. in Ampallas, Mamuju, West Sulawesi, Indonesia
Authors: Isyrini Rantih , Werorilangi Shinta , Mashoreng Supriadi , Faizal Ahmad , Rachim Rastina , Tahir Akbar 
Published: June 2018

The study was to determine the concentrations of Zn in porewater and fine roots of Rhizophora sp., and to examine their interactions with mangrove densities and physico-chemical. Porewater samples, fine roots, and sediments were collected in a 100 m2 plot at each site with different mangrove densities. The average Zn concentrations in mangrove roots in the study area were 0 – 58.21 mg/kg, suggested the capability of mangrove roots in retaining Zn. The average dissolved Zn concentrations in porewater were 0.63 mg/L – 3.50 mg/L, illustrated the amount of Zn bioavailable form and its potential release to the adjacent environment. The Zn concentrations in porewater did not correlate significantly with the densities of mangroves. The concentrations of Zn in roots increased as the densities were higher, which is possibly caused by the absence of mangrove at Site 1. The study discovered the important roles of organic content and silt/clay in Zn sorption thus affect Zn levels in porewater. The concentrations of Zn in mangrove roots increased as the pH of sediment and porewater decreased.
The influence of a green roof drainage layer on retention capacity and leakage quality
Authors: Baryła Anna , Karczmarczyk Agnieszka , Brandyk Andrzej , Bus Agnieszka 
Published: June 2018

Abstract
The aim of the research was to determine the influence of the substrate and different drainage materials on retention capacity and runoff water quality from three green roof containers. Phosphates were chosen as the water quality indicator based on their potential adverse impact on water quality in urban rainwater collectors. The field experiment was conducted at the Warsaw University of Life Sciences Water Center meteorological station in years 2013–2015. In terms of precipitation, the monitoring period covered a wet (+147.1 mm), average (+42.7 mm) and dry (− 66.3 mm) year. Leakage from the containers was recorded when the substrate moisture exceeded 20% and precipitation exceeded 3.5 mm/d for washed gravel, or 5.0 mm/d for a polypropylene mat and expanded clay. Phosphates were observed in leachates from all containers, with higher values observed in the second year of monitoring. As the result of this study, it can be concluded that the polypropylene mat and aggregates create different conditions for the formation of the leachate, in both volumes and its chemistry. The drainage layer made from a polypropylene mat is the most effective in terms of rainwater retention capacity and the resulting leachate quality.
Recent Developments on Phenstatins as Potent Antimitotic Agents
Authors: Chen Xing , Wang Shi-Meng , Kumar Gajjela Bharath , Bare Grant A.L. , Leng Jing , Bukhari Syed Nasir Abbas , Qin Hua-Li 
Published: June 2018

Background:
Phenstatin and their derivatives display remarkable antiproliferative
activity toward a wide variety of preclinical tumor models. Structural simplicity and
excellent stability of phenstatins offer a stimulating premise for developing various derivatives
with profound antimitotic activity and excellent cytotoxicity.

Objective:
To do analysis of literature that phenstatins derivatives inhibit tubulin
polymerization through their interaction at the colchicine binding site of microtubules and
arrest the G2/M phase of the cell cycle. In addition, phenstatin derivatives are undergoing
clinical evaluation as vascular targeting/disrupting agents and also exhibit direct antiangiogenic
properties.

Methods:
An organised well designed and appropriately managed search of bibliographic
databases for peer-reviewed research literature using a focused review question and inclusion/
exclusion criteria has been done for this article.

Conclusion:
In this review article, the synthesis and structure-activity relationships of
phenstatin and a wide number of their reported analogues with modifications to ring A,
ring B, and to the keto position are discussed in the perspective of medicinal chemistry
with proper conclusion.
Impacto de la ImperIal Germany de Veblen en los enfoques estructuralistas y de la teoría de la dependencia
Authors: Baca William 
Published: June 2018

<em><em></em></em>El presente artículo identifica puntos en común y diferencias entre el estructuralismo latinoamericano, la teoría de la dependencia y el texto Imperial Germany (1915) de Thorstein Veblen. Se explora la conexión en aspectos tales como dependencia en el sendero, tecnología y política económica. Imperial Germany se asemeja a varias de las principales recomendaciones de políticas de los estructuralistas y teóricos de la dependencia. Empero, el estructuralismo está más cercano a las ideas de los institucionalistas y del mismo Veblen. En conclusión, estructuralistas y la versión de Veblen en Imperial Germany concuerdan en que una política industrial debe ser guiada por el gobierno, aunque Veblen y los institucionalistas claramente presentan el cambio social mediante mejoras tecnológicas, algo que el estructuralismo no describe.
Diseño y contribución de un modelo para la priorización de actividades agroalimentarias: su aplicación al caso de Baja California
Authors: Avendaño Ruiz Belem Dolores , Astorga Ceja Juana , Acosta Martínez Ana Isabel , Hernández Alcantar Myriam Livier 
Published: June 2018

Asignar fondos públicos entre alternativas competitivas requiere la elaboración expresa de modelos que evalúen y seleccionen aquellas que cumplan tanto con la meta planteada como con los criterios de elección. La Fundación Produce de B. C. distribuía sus recursos sin un esquema que evaluara la contribución económica de las actividades agroalimentarias de la entidad. El objetivo de este documento es presentar el diseño y la construcción del modelo de priorización de las mismas, como un instrumento para orientar la política del gasto público en una entrega transparente y priorizada, identificando aquellas, cuyos efectos multiplicadores tienen un impacto claro por su dinamismo, participación en la estructura productiva y grado de especialización en el mercado. Los resultados muestran que para B. C., estas son el espárrago, alfalfa y trigo.