bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potentially inappropriate medications with polypharmacy increase the risk of falls in older Japanese patients: 1‐year prospective cohort study
Authors: Masumoto Shoichi , Sato Mikiya , Maeno Takami , Ichinohe Yumiko , Maeno Tetsuhiro 
Published: March 2018

AimWe aimed to evaluate whether potentially inappropriate medications (PIMs) increase the risk for adverse clinical outcomes including falls, emergency department (ED) visits and unplanned hospitalizations in older Japanese patients with chronic diseases, comparing the difference between patients with and without polypharmacy.MethodsA prospective observational cohort study was carried out in a Japanese outpatient primary care clinic. Baseline data was collected from January to March 2016. A total of 740 patients aged ≥65 years with chronic diseases were enrolled and were followed up at 1 year; falls, ED visits and unplanned hospitalizations were recorded. A questionnaire and review of the patients’ medical records were used to collect information regarding sociodemographic status, comorbidities and medication prescriptions. PIMs were defined using the Screening Tool of Older Person's Prescriptions criteria version 2. Using logistic regression analysis, the incidence of falls, and ED visits and hospitalizations were compared between patients with and without PIMs, stratifying by number of prescriptions: those with five or more prescriptions and those with fewer than five prescriptions.ResultsPIMs were identified in 32.3% of enrolled patients. After stratification by number of prescriptions, PIMs were significantly associated with falls in the group with polypharmacy (OR 2.03, 95% CI 1.11–3.69). This association was not seen in the group without polypharmacy. PIMs were not associated with ED visits or hospitalizations at the 1‐year follow up upon multivariate analysis.ConclusionsThe combination of PIMs and polypharmacy might increase the risk of falls, therefore clinicians need to pay attention to both PIMs and polypharmacy. Geriatr Gerontol Int 2018; 18: 1064–1070.
Long‐term tolerability, immunogenicity and efficacy of Nuwiq® (human‐cl rhFVIII) in children with severe haemophilia A
Authors: Klukowska A. , Szczepański T. , Vdovin V. , Knaub S. , Bichler J. , Jansen M. , Dzhunova I. , Liesner R. J. 
Published: March 2018

IntroductionNuwiq® (human‐cl rhFVIII, simoctocog alfa) is a 4th generation recombinant human FVIII, without chemical modification or fusion with any other protein, produced in a human cell line.Aim/MethodsThis study (GENA‐13) was an extension of the GENA‐03 study in which previously treated children aged 2‐12 years with severe haemophilia A received Nuwiq® prophylaxis for ≥6 months. GENA‐13 examined long‐term tolerability, immunogenicity and efficacy of Nuwiq® prophylaxis in children.ResultsOf 59 patients enrolled in GENA‐03, 49 continued Nuwiq® prophylaxis in GENA‐13 for a median (range) of 30.0 (9.5‐52.0) months. No patient withdrew due to drug‐related adverse events or developed inhibitors. Only 2 of 20 518 infusions were associated with possibly related adverse events (dyspnoea, fever). The estimated annualized bleeding rate (ABR) was 0.67 (95% CI: 0.44, 1.02) for spontaneous and 2.88 (95% CI: 1.86, 4.46) for all bleeds. Younger children (2‐5 years) had lower ABRs than children aged 6‐12 years. Annualized bleeding rates were reduced in GENA‐13 vs GENA‐03, especially for spontaneous bleeds in younger children (71% reduction; ABR ratio 0.29 [95% CI: 0.11, 0.74]). Nuwiq® efficacy was rated as excellent/good in the treatment of 83.0% of 305 evaluated breakthrough bleeds. Surgical prophylaxis with Nuwiq® was rated as excellent for all 17 assessed procedures.ConclusionLong‐term treatment with Nuwiq® for the prevention of bleeds in children with severe haemophilia A was well tolerated, effective and reduced spontaneous bleeding by up to 70% compared with GENA‐03.
Preparation of carbon/carbon‐ultra high temperature ceramics composites with ultra high temperature ceramics coating
Authors: Xu Lin , Cheng Jia , Li Xingchao , Zhang Yin , Fan Zhen , Song Yongzhong , Feng Zhihai 
Published: March 2018

AbstractIn order to increase the oxidation resistance of carbon/carbon (C/C) composites at long‐term high temperature, C/C‐Ultra High Temperature Ceramics composites (UHTCs) with a dual‐layer UHTCs oxidation coating was successfully designed and fabricated. The microstructure and ablation resistance were investigated and discussed. After ablation in arc‐heated wind tunnel with temperature being 2200°C for 1000s, the mass ablation rate and linear ablation rate were −1.9 × 10−2 mg/cm2s and 2.9 × 10−5 mm/s, respectively. The formation of thermodynamically compatible oxide scale including ZrO2 skeleton and SiO2 or Zr–Si–O glass on the surface were mainly contributed to the excellent ablation resistance of the composite.
Stability and calorimetric studies of silico‐ferrites of calcium aluminum and magnesium
Authors: Zöll Klaus , Benisek Artur , Dachs Edgar , Kahlenberg Volker , Saxer Andreas , Tropper Peter , de Villiers Johan 
Published: March 2018

AbstractIn a systematic study on silico‐ferrites of calcium aluminum and magnesium (SFCA phases) this investigation focuses on synthesis of silicon‐free SFCA‐type compounds with low‐MgO contents (~1.00 apfu—atoms per formula unit). Previous studies revealed the existence of iron‐rich SFCA phases similar to the SFCA‐I structure with the chemical composition Ca3MgAl6Fe10O28 (Metall Mater Trans B. 2017;48:2207). The experimental results in the quaternary Fe2O3‐CaO‐Al2O3‐MgO system confirm large stability fields of 2 silicon‐free ferrites FCAM‐I and FCAM‐III, which are members of the homologous series M14+6nO20+8n (n = 1, 2). Starting with compositions corresponding to Ca3MgAlxFe16‐xO28 (with increasing aluminum content from x = 0‐12 apfu), it was possible to synthesize these phases with an x‐value ≥2 apfu, which corresponds to Al2O3 contents ≥7.14 wt%. Synthesis of pure silicon‐free ferrites with n = 1 (FCAM‐I) and 2 (FCAM‐III) and silicon‐bearing ferrites with n = 0 (SFCA) was possible. Samples were characterized by electron probe microanalysis, powder diffraction, and subsequently studied using relaxation calorimetry measurements in combination with differential scanning calorimetry for determination of the heat capacities and standard entropies S°(298). The corresponding values are S°(298) = 650.3 ± 4.6 J/mol·K for SFCA, S°(298) = 864.5 ± 6.1 J/mol·K for FCAM‐I, and S°(298) = 1206.2 ± 8.4 J/mol·K for FCAM‐III. These thermodynamic data are a step toward a rigorous quantitative thermodynamic modeling of the iron ore sintering process.
Considering dominance in reduced single‐step genomic evaluations
Authors: Ertl J. , Edel C. , Pimentel E.C.G. , Emmerling R. , Götz K.‐U. 
Published: March 2018

SummarySingle‐step models including dominance can be an enormous computational task and can even be prohibitive for practical application. In this study, we try to answer the question whether a reduced single‐step model is able to estimate breeding values of bulls and breeding values, dominance deviations and total genetic values of cows with acceptable quality. Genetic values and phenotypes were simulated (500 repetitions) for a small Fleckvieh pedigree consisting of 371 bulls (180 thereof genotyped) and 553 cows (40 thereof genotyped). This pedigree was virtually extended for 2,407 non‐genotyped daughters. Genetic values were estimated with the single‐step model and with different reduced single‐step models. Including more relatives of genotyped cows in the reduced single‐step model resulted in a better agreement of results with the single‐step model. Accuracies of genetic values were largest with single‐step and smallest with reduced single‐step when only the cows genotyped were modelled. The results indicate that a reduced single‐step model is suitable to estimate breeding values of bulls and breeding values, dominance deviations and total genetic values of cows with acceptable quality.
Biofilm‐forming ability of Alicyclobacillus spp. isolates from orange juice concentrate processing plant
Authors: Prado Daniela Biral do , Fernandes Meg da Silva , dos Anjos Márcia Maria , Tognim Maria Cristina Bronharo , Nakamura Celso Vataru , Machinski Junior Miguel , Mikcha Jane Martha Graton , de Abreu Filho Benício Alves 
Published: March 2018

AbstractThe objective of this study was to evaluate the biofilm‐forming ability of Alicyclobacillus spp. isolates. Biofilm formation was evaluated under a stainless steel surface using orange juice as a culture medium at different temperatures (28 and 45  °C, 30 and 45  °C, and 45 and 60  °C) and contact times (24, 72, and 120 hr). The degree of hydrophobicity and the survival time of the different isolates on the abiotic surface were also investigated. Five Alicyclobacillus spp. isolates from the orange juice industry and a reference strain of Alicyclobacillus acidoterrestris 0244T were used. The biofilm formation of Alicyclobacillus was observed from 24 hr of contact in at least one temperature tested, as a function of the different incubation times and temperatures. Alicyclobacillus spp. presented variations in the degree of hydrophobicity. Surprisingly, two biofilm‐forming isolates (CCT 7230 and CCT 7346) were hydrophilic, with hydrophobicity index <20%, therefore, they are not necessarily related to cell hydrophobicity and adherence of Alicyclobacillus to the stainless steel surface. This study demonstrated that Alicycclobacillus spp. isolates from the industry can survive the processing conditions and form biofilms on contact surfaces.Practical applicationsAlicyclobacillus spp. may be present in the orange juice industry and form biofilms. In addition, it is known that the equipment is exposed to a wide temperature range for different periods of time and that poorly sanitized stainless steel equipment and surface can provide substrates for the formation of biofilms by Alicyclobacillus spp. Therefore, it is of the most importance to understand how these factors influence the adhesion and formation of Alicyclobacillus spp. in the processing of orange juice.
Advanced meat preservation methods: A mini review
Authors: ur Rahman Ubaid , Sahar Amna , Ishaq Anum , Aadil Rana Muhammad , Zahoor Tahir , Ahmad Muhammad Haseeb 
Published: March 2018

AbstractDevelopment of various novel thermal and nonthermal techniques has shown potential applications in meat processing and preservation. Consumer's demand of meat products with esteemed quality, wholesomeness, and superior safety has led to the commercial introduction of these innovative methods. Accordingly, this treatise outlines the potential of several advanced thermal and nonthermal methods like super‐chilling, ultrarapid freezing, immersion vacuum cooling, hydrofluidization freezing, impingement freezing, electrostatic‐assisted freezing, pressure‐shift freezing, acidic electrolyzed water coupled with high hydrostatic pressure, and nonthermal plasma technique for preserving meat quality and prolongation of shelf stability. This article also highlights the advancements in the packaging technology like use of linear low‐density polyethylene‐based active clay nanocomposite films and resulted benefits for the meat sector. Additionally, consumer responses to various meat products preserved with these technologies are also discussed in this critique. The focal objective of the current discourse is to reconnoiter the aptitude of these novel techniques in meat preservation so that these methods can be adopted at commercial scale in a much broader sense.Practical applicationsFor decades, several methods have been adopted for preservation of meat. With technological advancements, meat industry is looking for some modern and economic preservation methods for meat and meat‐based products. In this regard, several nonconventional techniques like super‐chilling, hydrofluidization freezing, impingement freezing, electrostatic‐assisted freezing, and pressure‐shift freezing have shown their potential for effective meat preservation. Therefore, this article will be helpful for the meat industrialists to consider these techniques for commercial preservation of meat and meat products in a more effectual manner.
The inhibitory effect of traditional pomegranate molasses on S. typhimurium growth on parsley leaves and in mixed salad vegetables
Authors: Faour‐Klingbeil Dima , Todd Ewen C. D. 
Published: March 2018

AbstractPomegranate (PG) molasses is an essential condiment that is commonly used in Middle Eastern cuisine in local and international gastronomic markets. There is scarce information on the inhibitory effect of PG molasses on Salmonella growth mainly under in situ conditions and in a food matrix. PG molasses in different dilution ratios of 1:1 and 1:7, combined with sodium chloride (2%, v/v), vinegar (2.4%, v/v), and in a dressing mix was tested against Salmonella enterica serovar Typhimurium LT2 on parsley and salad vegetables. The results showed significant log reductions in Salmonella on parsley treated with PG solutions for 15, 30, and 60 min, reaching a level of 2.55 log cfu/g. The addition of sodium chloride (2%, v/v) and vinegar (2.4%, v/v) to PG molasses did not exert a synergistic or antagonistic effect on its antibacterial activity. Additionally, the application of PG molasses dressing on salads contaminated with low (3 log cfu/g) and high (6 log cfu/g) inoculum levels resulted in 2–3 log reduction independent of temperature (p < .05) compared with 0.5–1 log reduction for thorough washing alone which may damage the leaf surfaces. This study showed that PG molasses has a great efficacy against S. typhimurium and the potential to enhance the microbial safety of ready‐to‐eat salads and parsley leaves.Practical applicationsThe implication of fresh‐cut vegetables in food poisoning are well documented, at the same time, the washing methods in restaurants or home settings are reportedly not effective enough to mitigate the risks of pathogens found in vegetables. This study shows that Pomegranate (PG) molasses has a greater efficacy than chlorine (200 ppm) against S. typhimurium and achieved comparable to greater log reduction values than organic acids. The storage temperature and food matrix did not alter the potency of PG. The present work showed that promoting the use of PG as a natural additive and condiment to ready‐to‐eat (RTE) vegetables offers a great potential to effectively reduce the risk of Salmonella contamination and to improve their microbial safety. Furthermore, this study provided preliminary data that serve as additional inputs in quantitative microbial risk assessment models for estimating the risk of Salmonella infection associated with consuming RTE salads served in Mediterranean cuisines.
Putative virulence traits and antibiogram profile of Aeromonas spp. isolated from frozen white‐leg shrimp (Litopenaeus vannamei) marketed in Korea
Authors: De Silva B. C. J. , Hossain Sabrina , Wimalasena S. H. M. P. , Pathirana H. N. K. S. , Heo Gang‐Joon 
Published: March 2018

AbstractWe evaluated 44 strains of Aeromonas spp. consisting of five species; A. hydrophila, A. veronii, A. caviae, A. enteropelogenes, and A. media isolated from frozen white‐leg shrimp marketed in Korea. All the isolates were positive in DNase, protease, gelatinase, and lipase tests whereas 29 isolates (66%) were positive for slime production. Ten virulence genes were detected by PCR in which the prevalence of act, alt, ast, aerA, lip, ahyB, ser, fla, gcat, and ascV were 50%, 77%, 72%, 82%, 84%, 93%, 80%, 64%, 84%, and 23%, respectively. As observed in antibiogram, 100% resistance was detected in ampicillin and clindamycin while nalidixic acid, tetracycline, cephalothin, erythromycin, and trimethoprim‐sulfamethoxazole were resisted by 95%, 89%, 86%, 68%, and 66% of the isolates, respectively. Multiple antibiotic resistance index was >0.20 in 42/44 (95%) of the isolates. Overall, our results indicated that these aeromonads are indicative of a serious public health risk due to their virulence potential and the multiple‐antimicrobial resistance.Practical applicationsSimilar to other seafood, shrimp have been identified as vehicles of Aeromonas spp. which are the etiological agents of many foodborne infections. The gyrB gene sequencing and phylogenetic analysis confirmed the occurrence of five species of Aeromonas in frozen white‐leg shrimp marketed in Korea. Putative virulence properties were examined by both phenotypic tests and PCR assays whereby majority of the isolates exhibited the virulence both phenotypically and genetically. Besides, the disc diffusion test was carried out to assess the antibiotic susceptibility of the isolates. Following the results, the MAR index was calculated for each strain thereby suggested their high risk owing to MAR indices higher than 0.20. With our results, frozen white‐leg shrimp associated Aeromonas spp., exhibiting potential virulence and antimicrobial resistance, can be considered as a potential public health risk. Moreover, it is noteworthy that freezing the shrimp may not reduce the incidence of pathogenic Aeromonas.
First‐in‐human experience of left atrial appendage occlusion with the steerable FuStar sheath
Authors: Kleinecke Caroline , Gomez Monterrosas Omar , Scalone Giancarla , Lam Yat‐Yin , Shin Eun‐Seok , Bellmann Barbara , Brachmann Johannes , Park Jai‐Wun 
Published: March 2018

BackgroundDue the wide variability of left atrial appendage morphology left atrial appendage occlusion (LAAO) remains a challenging procedure. The steerable FuStar delivery sheath was designed to allow both, transseptal access and delivery of percutaneous devices. We here report the first‐in‐human experience of LAAO with the FuStar sheath.MethodsTwenty patients (76.6 ± 8.4 years; 12 (60%) males; CHA2DS2‐VASc score: 5.0 ± 2) with non‐valvular fibrillation and contraindications to oral anticoagulation underwent LAAO with the LAmbre device using the FuStar steerable sheath (Lifetech Scientific Corp., Shenzhen, China) at two german centers.ResultsSuccessful device implantation was achieved in all patients (100%). No periprocedural complications were observed. Procedure time, fluoroscopy time, contrast media, and radiation dose were 23.4 min ± 9.2, 11.9 min ± 4.1, 96.2 mL ± 45.7, and 2718.4 cG*cm2 ± 3835.3, respectively.ConclusionThis study demonstrates the feasibility and safety of the steerable FuStar sheath for LAAO.
Antinociceptive and anti-inflammatory effects of 1,2-bis-(4 methoxyphenylselanyl) styrene in mice: involvement of the serotonergic system
Authors: Anversa Roberta Gonçalves , Sousa Fernanda Severo Sabedra , Birmann Paloma Taborda , Lima David Borba , Lenardão Eder João , Bruning César Augusto , Savegnago Lucielli 
Published: March 2018

Abstract

Background
Pain is one of the most prevalent, costly and disabling conditions that reduces quality of life. Although there are many analgesics available, there is some concern regarding their efficacy, safety and side effects. Organic selenium compounds are attractive targets of various research groups due to their pharmacological properties.

Objectives
The aim of this study was to evaluate the antinociceptive and anti-inflammatory activity of 1,2-bis-(4-methoxyphenylselanyl) styrene (BMOSE) in mice, as well as to investigate the mechanism involved in the antinociceptive effect.

Methods
The animals were submitted to the formalin and glutamate tests. The assessment of the possible involvement of the serotonergic system in BMOSE antinociceptive activity was performed using the glutamate test. Also, we investigated the possible toxicity of the compound.

Key findings
1,2-bis-(4-methoxyphenylselanyl) styrene (0.1–50 mg/kg, i.g.) was efficient in avoiding nociception induced by glutamate and formalin and also reduced paw oedema. The possible involvement of 5-HT3 serotoninergic receptor antagonist ondansetron blocked the antinociceptive effect of BMOSE. The acute toxicity assays did not show any toxicity related to the administration of BMOSE (200 mg/kg).

Conclusions
It is possible to conclude that BMOSE has both antinociceptive and anti-inflammatory activity, and the serotoninergic system, more specifically, the 5-HT3 receptor, is involved in the effect.
Human periodontal ligament cells exhibit no endotoxin tolerance upon stimulation with Porphyromonas gingivalis lipopolysaccharide
Authors: Blufstein A. , Behm C. , Nguyen P. Q. , Rausch‐Fan X. , Andrukhov O. 
Published: March 2018

Background/ObjectivesEndotoxin tolerance is characterized by a state of hyporesponsiveness after confrontation with endotoxins such as lipopolysaccharides (LPS) at low concentrations. The aim of this study was to investigate, whether pretreatment with Porphyromonas gingivalis leads to endotoxin tolerance induction and possible alterations in toll‐like receptor (TLR) 2‐ and 4‐induced response in human periodontal ligament cells (hPDLCs).Material and MethodsPrimary hPDLCs were pretreated with P. gingivalis (0.1 or 0.3 μg/mL) LPS for 24 hours and afterwards treated with one of the following stimuli: P. gingivalis LPS (1 μg/mL); TLR4 agonist Escherichia coli LPS (0.1 μg/mL; 1 μg/mL); TLR2 agonist Pam3CSK4 (0.1 μg/mL; 1 μg/mL). The protein expression of interleukin (IL)‐6, IL‐8 and monocyte chemotactic protein‐1 was analyzed with quantitative polymerase chain reaction and enzyme‐linked immunosorbent assay. Gene expression levels of TLR2 and TLR4 were determined by quantitative polymerase chain reaction.ResultsPretreatment of cells with low concentrations of P. gingivalis LPS did not result in lower production of IL‐6, IL‐8 and monocyte chemotactic protein‐1 compared to control group. In some cases, pretreated cells exhibited lower gene expression levels of TLR2 and TLR4 compared to non‐pretreated cells.ConclusionThe results of this study implicate that hPDLCs do not develop endotoxin tolerance. Furthermore, the amplitude of the inflammatory response shows no significant dependency on TLR2 and TLR4 expression levels.
Evaluation of updated sepsis scoring systems and systemic inflammatory response syndrome criteria and their association with sepsis in equine neonates
Authors: Wong D. M. , Ruby R. E. , Dembek K. A. , Barr B. S. , Reuss S. M. , Magdesian K. G. , Olsen E. , Burns T. , Slovis N. M. , Wilkins P. A. 
Published: March 2018

BackgroundThe original equine sepsis score provided a method of identifying foals with sepsis. New variables associated with sepsis have been evaluated, but the sepsis score has not been updated.ObjectivesTo evaluate the sensitivity and specificity of 2 updated sepsis scores and the systemic inflammatory response syndrome (SIRS) criteria in regard to detecting sepsis in foals.AnimalsTwo‐hundred and seventy‐three ill foals and 25 healthy control foals.MethodsHistorical, physical examination, and clinicopathologic findings were used to calculate the original sepsis score and 2 updated sepsis scores. SIRS criteria were also evaluated. Sepsis scores and positive SIRS scores were statistically compared to foals with sepsis.ResultsOne‐hundred and twenty‐six foals were septic and 147 sick‐nonseptic. The original and updated sepsis scores were significantly higher in septic foals as compared to sick‐nonseptic and healthy foals. The sensitivity and specificity of the updated sepsis scores to predict sepsis were not significantly better than those of the original sepsis score. One‐hundred and twenty‐seven of 273 (46.5%) foals met the original SIRS criteria and 88/273 (32%) foals met the equine neonatal SIRS criteria. The original SIRS criteria had similar sensitivity and specificity for predicting sepsis as did the 3 sepsis scores in our study.Conclusions and Clinical ImportanceThe updated sepsis scores did not provide improved ability in predicting sepsis. Fulfilling the original SIRS criteria provided similar sensitivity and specificity in predicting sepsis as the modified sepsis score and might serve as a diagnostic aid in identifying foals at risk for sepsis.