bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia
Authors: Cooley Sarah , He Fiona , Bachanova Veronika , Vercellotti Gregory M. , DeFor Todd E. , Curtsinger Julie M. , Robertson Paul , Grzywacz Bartosz , Conlon Kevin C. , Waldmann Thomas A. , McKenna David H. , Blazar Bruce R. , Weisdorf Daniel J. , Miller Jeffrey S. 
Published: July 2019

Abstract
In vivo expansion of haploidentical natural killer (NK) cell infusions with interleukin-2 (IL-2) can induce remission of refractory acute myeloid leukemia, but efficacy may be hampered by concurrent stimulation of host regulatory T cells. To overcome this limitation, we substituted the NK homeostatic factor IL-15 in 2 phase 1/2 trials. Forty-two patients received either intravenous (IV) (NCT01385423) or subcutaneous (SC) (NCT02395822) recombinant human IL-15 (rhIL-15) after lymphodepleting chemotherapy and haploidentical NK cells. Escalating doses of rhIL-15 (0.3-1.0 μg/kg) were given on 12 consecutive days in a phase 1 trial. Of 26 patients, 36% had robust in vivo NK-cell expansion at day 14, and 32% achieved complete remission. Hypothesizing that SC dosing of rhIL-15 would be safer and better tolerated, 16 patients received 10 once per day doses of SC rhIL-15 at 2.0 μg/kg on a phase 2 trial. NK-cell expansion at day 14 was seen in 27% of the patients, and 40% achieved remission. rhIL-15 induced better rates of in vivo NK-cell expansion and remission compared with previous trials with IL-2, but it was associated with previously unreported cytokine release syndrome (CRS) after SC but not IV dosing. CRS was observed in 56% of patients given SC rhIL-15 (with concurrent neurologic toxicity in 5 of 9 patients) and was responsive to steroids and tocilizumab. SC administration was associated with slower pharmacokinetic clearance and higher levels of IL-6 than IV dosing. These novel trials testing the use of IL-15 to potentiate cell therapy suggest that dosing schedules based on pharmacokinetics and pharmacodynamics will preserve the therapeutic benefits of IL-15 and minimize CRS. These trials were registered at www.clinicaltrials.gov as #NCT01385423 and #NCT02395822.
Psychogenic antecedents and apparel customization: moderating effects of gender
Authors: Seo Su-kyung , Lang Chunmin 
Published: July 2019

AbstractThe impact of gender is critical in consumer behavior; however, gender differences have been overlooked in consumer studies. The purpose of this study is to examine how behavior-inducing psychogenic needs (i.e., need for uniqueness, self-promotion, and social identity) influence the way individuals perceive apparel customization, leading to buying intention of customized apparel products. Further, to identify whether gender plays a moderating role in the relationships between those psychogenic needs and the perception of apparel customization. The conceptual model was tested by conducting an online survey of 338 samples from college students in the United States. Structural equation modeling (SEM) was utilized for hypotheses testing. The structural multi-group model was conducted and path coefficient comparisons were made to test the moderating effects of gender. The results indicated that need for uniqueness and social identity are strong determinant factors in eliciting positive perceptions of customization, ultimately resulting in buying intention of customized apparel products; however, the effects of self-promotion was not significant. The results also illustrated that differences exist in antecedents toward customization perception between genders. Both genders are commonly motivated by need for uniqueness. However, males are more driven by social identity and need for uniqueness, whereas females are more inspired by self-promotion. The results offer managerial implications by providing retailers with consumers’ behavior toward fashion customization based on gender differences.
Suspected pleuroparenchymal fibroelastosis relapse after lung transplantation: a case report and literature review
Authors: Rasciti Edoardo , Cancellieri Alessandra , Romagnoli Micaela , Dell'Amore Andrea , Zompatori Maurizio 
Published: July 2019

Pleuroparenchymal fibroelastosis (PPFE) is a very rare lung disease characterized by dense fibrous thickening of the visceral pleura and intraalveolar fibrosis containing prominent elastosis, with typical upper lobe predominance. PPFE usually shows progressive restrictive ventilatory impairment refractory to medical treatment; bilateral lung transplantation currently remains the only available therapeutic option. In this report, we describe a case of suspected PPFE relapse after lung transplantation that, to our knowledge, has never been described in the medical literature. A 48-year-old male with idiopathic pleuroparenchymal fibroelastosis underwent a bilateral lung transplant in our department. 8 months later, he presented with progressively worsening clinical condition, his respiratory state gradually deteriorated. High-resolution CT again showed bilateral diffused parenchymal consolidations, with prevalence in the upper lobes and subpleural regions. A PPFE relapse was therefore suspected, so he was listed for lung retransplantation, which was performed ten months after the first transplant. Histopathological analysis of the second explanted lung again confirmed the diagnosis of PPFE. The case highlights the possibility of PPFE relapse after lung transplantation, that may add to the increasing evidence of an underlying auto-immune mechanism contributing to its pathogenesis.
The grant is dead, long live the data - migration as a pragmatic exit strategy for research data preservation
Authors: Zielinski Tomasz , Hay Johnny , Millar Andrew J. 
Published: July 2019

Open research, data sharing and data re-use have become a priority for publicly- and charity-funded research. Efficient data management naturally requires computational resources that assist in data description, preservation and discovery. While it is possible to fund development of data management systems, currently it is more difficult to sustain data resources beyond the original grants. That puts the safety of the data at risk and undermines the very purpose of data gathering. PlaSMo stands for ‘Plant Systems-biology Modelling’ and the PlaSMo model repository was envisioned by the plant systems biology community in 2005 with the initial funding lasting till 2010. We addressed the sustainability of the PlaSMo repository and assured preservation of these data by implementing an exit strategy. For our exit strategy we migrated data to an alternative public repository of secured funding. We describe details of our decision process and aspects of the implementation. Our experience may serve as an example for other projects in similar situation. We share our reflections on sustainability of biological data management and the future outcomes of its funding. We expect it to be a useful input for funding bodies.
Lisfranc fracture-dislocations: current management
Authors: Moracia-Ochagavía Inmaculada , Rodríguez-Merchán E. Carlos 
Published: July 2019

It is essential to know and understand the anatomy of the tarsometatarsal (TMT) joint (Lisfranc joint) to achieve a correct diagnosis and proper treatment of the injuries that occur at that level. Up to 20% of Lisfranc fracture-dislocations go unnoticed or are diagnosed late, especially low-energy injuries or purely ligamentous injuries. Severe sequelae such as post-traumatic osteoarthritis and foot deformities can create serious disability. We must be attentive to the clinical and radiological signs of an injury to the Lisfranc joint and expand the study with weight-bearing radiographs or computed tomography (CT) scans. Only in stable lesions and in those without displacement is conservative treatment indicated, along with immobilisation and initial avoidance of weight-bearing. Through surgical treatment we seek to achieve two objectives: optimal anatomical reduction, a factor that directly influences the results; and the stability of the first, second and third cuneiform-metatarsal joints. There are three main controversies regarding the surgical treatment of Lisfranc injuries: osteosynthesis versus primary arthrodesis; transarticular screws versus dorsal plates; and the most appropriate surgical approach. The surgical treatment we prefer is open reduction and internal fixation (ORIF) with transarticular screws or with dorsal plates in cases of comminution of metatarsals or cuneiform bones. Cite this article: EFORT Open Rev 2019;4:430-444. DOI: 10.1302/2058-5241.4.180076
Que a Força esteja contigo – os desafios da publicidade na nova galáxia comunicacional
Authors: Balonas Sara 
Published: July 2019

Pelo menos desde o início do século XXI que a Publicidade, tal como a conhecemos, vive numa crise de identidade. No caso português, como noutras geografias, o panorama económico, social e tecnológico alterou-se significativamente. A crise económica e financeira, a quebra do consumo, a valorização da opinião dos círculos informais em detrimento das campanhas publicitárias, mas também a valorização do digital e do tecnológico, trouxeram novos desafios. Todavia, as agências de publicidade não reagiram prontamente, optando por manter os seus modelos de negócio e de funcionamento. Plataformas como a Televisão, a Rádio ou a Imprensa - palcos onde as agências se sentiam confortáveis - deram lugar ao digital e ao online. Sites, aplicações, redes sociais, gestão de conteúdos, gaming, storytelling, enfim, uma plêiade de novos vocábulos entraram no quotidiano dos interlocutores da área, substituindo a desgastada “Publicidade”, associada a grandes investimentos.Vaticinou-se a morte da Publicidade (Rust & Oliver, 1994). As start ups tecnológicas pareciam ter a resposta certa. O meio passou a ser hipervalorizado.Eis o grande equívoco: a publicidade tem sido confundida com as plataformas onde é veiculada. Contudo, a publicidade é, acima de tudo, uma técnica de comunicação. Orienta-se por métodos, técnicas e princípios adaptando-se ao offline e ao online. Assim, deve ser julgada pela sua competência comunicacional, discutida pela validade dos conteúdos. É aí que reside a sua essência. Como a avaliar? De todas as características que a Publicidade possui, duas são absolutamente determinantes: a capacidade de fazer uso da persuasão e da criatividade por forma a exercer influência sobre o consumidor ou cidadão. Reconhecer este valor é condição para compreender a essência da Publicidade.
A preservação da água em um objeto de aprendizagem: saberes e possibilidades de ensino
Authors: Becker Elsbeth Léia Spode , Rossato Jussane , Ellwanger Anderson 
Published: July 2019

Este artigo tem como objetivo apresentar um Objeto de Aprendizagem (OA) desenvolvido para mostrar o processo de produção de energia a partir da matriz ‘água’, sensibilizar para a sua preservação e registrar possibilidades de pesquisar em educação. O OA é destinado aos alunos do Ensino Básico e foi desenvolvido para complementar conteúdos curriculares sobre o tema envolvendo conteúdos de Física, Matemática e Geografia. A metodologia perpassou pela aprendizagem colaborativa e envolveu a multimodalidade de linguagem a partir da aula teórica, a música, o texto crítico e o OA. O resultado obtido por meio de múltiplas ferramentas mostrou-se eficaz para abordar o tema mostrando possibilidades de reutilização da água nas ações cotidianas dos estudantes. Sobre os saberes e possibilidades de ensino discutidos por meio do OA, a investigação possibilitou atualizar demandas emergenciais para cuidar do planeta e multiplicar as formas de conexão de linguagens e de abordagens no ensino de Ciências.
PALAVRAS-CHAVE: Ensino de Ciências; Objeto de aprendizagem; Reutilização da água; Usina hidrelétrica.
Feira de Ciências: aproximando estudantes da educação básica da pesquisa de iniciação científica
Authors: Costa Luzinete Duarte , Mello Geison Jader , Roehrs Marfa Magali 
Published: July 2019

Este artigo analisa de que modo as feiras de Ciências podem constituir uma oportunidade para a aprendizagem e para a formação de uma identidade científica no contexto da Educação Básica. A pesquisa adota uma abordagem qualitativa, segundo os moldes da análise documental. Analisa-se a compreensão científica de estudantes premiados com bolsas de iniciação científica júnior, participantes da Feira de Ciências do Território do Alto Paraguai, em Mato Grosso, em 2016. O objetivo específico foi o de identificar características da compreensão científica desencadeada pela valorização do conhecimento construído por esses bolsistas. Os dados obtidos a partir de documentos da autoria desses estudantes (projetos e relatórios) revelaram que, além de ser um evento importante, a feira é uma estratégica metodológica mediadora da Educação e incentiva as atividades científicas por meio da socialização e do intercâmbio que possibilita.
PALAVRAS-CHAVE: Feira de Ciências. Iniciação Científica. Estudantes da Educação Básica.
O número PI e o conceito de aproximação: possíveis caminhos advindos da História para o ensino da Matemática Elementar
Authors: Pommer Wagner Marcelo 
Published: July 2019

Este texto objetivou apresentar e discutir a questão de aproximação em processos infinitos no entorno da História da Matemática como aporte para tecer uma possível abordagem significativa do número PI na escolaridade básica. O tema das aproximações se constitui em uma conexão com os números racionais, pois os números irracionais somente existem no mundo pragmático através de representações decimais finitas. A busca em documentos no entorno da História da Matemática revelou diversos momentos das civilizações antigas que permitem um diálogo com a epistemologia, perfazendo uma conexão com referenciais didáticos entre temas matemáticos diversos, o que possibilita emergir situações de ensino imersas numa retroação presente-passado.
PALAVRAS-CHAVE: História da Matemática. PI. Aproximação.
Utilizando games para ensinar Ciências: percepções de estudantes do Ensino Fundamental
Authors: Shaw Gisele Soares Lemos , Ribeiro Marcelo Silva de Souza , Rocha João Batista Teixeira da 
Published: July 2019

Dentre as diversas TIC empregadas atualmente, o uso de games tem sido uma possibilidade interessante, pois pode dar novos sentidos ao uso do computador e gerar aprendizagem. Este artigo é fruto de uma pesquisa qualitativa e envolve a investigação das potencialidades da utilização de três games no processo de ensino-aprendizagem do conteúdo sistemas do corpo humano, nas percepções de uma professora e estudantes de sétima série do Ensino Fundamental. Os dados foram coletados por meio de observação, questionários, entrevistas individuais e entrevistas em grupo focal. Para os estudantes, o uso de games no ensino de ciências auxilia na motivação, facilita a compreensão dos conteúdos, além de ser algo divertido, dinâmico e que reduz a indisciplina em classe. Considera-se as contribuições positivas desses games à aprendizagem de ciências, mas aponta-se efeitos negativos, tais como ansiedade e nervosismo nos jogadores.
PALAVRAS-CHAVE: Aprendizagem. Games. Motivação.
Hume, Mandeville, Butler, and “that Vulgar Dispute”
Authors: Frykholm Erin 
Published: July 2019

Abstract
The debate over whether human motivations are fundamentally selfinterested or benevolent consumed Shaftesbury, Mandeville, and Hutcheson, but Hume – though explicitly indebted to all three – almost entirely ignores this issue. I argue that his relative silence reveals an overlooked intellectual debt to Bishop Butler that informs two distinguishing features of Hume’s view: first, it allows him to appropriate compelling empirical observations that Mandeville makes about virtue and moral approval; second, it provides a way of articulating a fundamental criticism of Shaftesbury and Hutcheson on the issue of virtuous motivation. From this position, Hume is able to reframe the question of virtue according to the approbation of the spectator, rather than the internal aims of the agent.
Regularity Criteria for Navier-Stokes Equations with Slip Boundary Conditions on Non-flat Boundaries via Two Velocity Components
Authors: Veiga Hugo Beirão da , Yang Jiaqi 
Published: July 2019

AbstractH.-O. Bae and H.J. Choe, in a 1997 paper, established a regularity criteria for the incompressible Navier-Stokes equations in the whole space ℝ3based on two velocity components. Recently, one of the present authors extended this result to the half-space case$\begin{array}{} \displaystyle \mathbb{R}^3_+ \end{array}$. Further, this author in collaboration with J. Bemelmans and J. Brand extended the result to cylindrical domains under physical slip boundary conditions. In this note we obtain a similar result in the case of smooth arbitrary boundaries, but under a distinct, apparently very similar, slip boundary condition. They coincide just on flat portions of the boundary. Otherwise, a reciprocal reduction between the two results looks not obvious, as shown in the last section below.
Universal Basic Income and the Natural Environment: Theory and Policy
Authors: MacNeill Timothy , Vibert Amber 
Published: July 2019

Abstract
We analyze the environmental implications of basic income programs through literature review, government documents, pilot studies, and interviews eliciting expert knowledge. We consider existing knowledge and then use a grounded approach to produce theory on the relationship between a basic income guarantee and environmental protection/damage. We find that very little empirical or theoretical work has been done on this relationship and that theoretical arguments can be made for both positive and negative environmental impacts. Ultimately, this implies, the environmental impact of a basic income program will be dependent on program design. These insights allow us to generate a toolkit of policy proposals to assist in the development of green basic income programs via either conditions, additions, or complements.
Are Serbian tourists worried? The effect of psychological factors on tourists’ behavior based on the perceived risk
Authors: Kovačić Sanja , Jovanović Tamara , Miljković Ðurđa , Lukić Tin , Marković Slobodan B. , Vasiljević Ðorđije A. , Vujičić Miroslav D. , Ivkov Milan 
Published: July 2019

AbstractRecent natural hazards (floods and wildfires) which hit some of the most visited Greek tourist destinations during the summer season 2018 are threatening to decrease the number of tourist visits in the affected regions. As these regions, being namely Chalkidiki, Olympic Riviera and regions surrounding Athens and Thessaloniki, are the most popular summer destinations for Serbian tourists, it is interesting to examine how natural hazards that occurred there influence tourist behavior based on the perceived risk. The study aims to explore the role of psychological factors such as different personality traits and tourism worries on the tourist behavior based on the perceived risk of affected destinations. Moreover, the assumption was that tourism worrieswill mediate the relationship between analyzed personality traits and tourist behavior based on the perceived risk. Although previous studies investigated the effect of different psychological factors on tourist behavior based on the perceived risk, this is the first study to explore the interaction of different psychological factors including tourism worries, which previously were not analyzed in this context. Besides theoretical contribution, practical implications are also further discussed in the paper within the realm of their use for destination managers.
The reaction of lignin model compounds during enzymatic bleaching with a Curvularia verruculosa haloperoxidase: impact on chlorination
Authors: Herold-Majumdar Owik M. , Loureiro Pedro E.G. , Ullrich René , Felby Claus 
Published: July 2019

AbstractRecent developments in enzymatic bleaching processes have led to replacement strategies of harsh chemicals by haloperoxidases. For this purpose, it is important to control the haloperoxidase-mediated formation of adsorbable organic halides (AOX). In this study, we studied the chlorination of monomeric and dimeric lignin model substrates. Guaiacol, acetovanillone, veratryl alcohol, pinoresinol and adlerol were treated with Curvularia verruculosa haloperoxidase and compared to a sodium hypochlorite treatment. High-performance liquid chromatography-diode array detection-mass spectrometry (HPLC-DAD-MS) analysis was employed for the characterization of the reaction products. Our results show that while treatment with haloperoxidases in the presence of sodium chloride and hydrogen peroxide leads to no improvement in AOX formation compared to chemical treatment with NaOCl, addition of ammonium chloride substantially lessens chlorination and promotes β-O-4 ether bond cleavage. The use of ammonium chloride in conjunction with enzymatic haloperoxidase-based bleaching could be a route to minimize lignin chlorination.
Intrapartum prediction of birth weight with a simplified algorithmic approach derived from maternal characteristics
Authors: Yapan Piengbulan , Promchirachote Chirameth , Yaiyiam Chutima , Rahman Suraiya , Pooliam Julaporn , Wataganara Tuangsit 
Published: July 2019

Abstract

Objective
To derive and validate a population-specific multivariate approach for birth weight (BW) prediction based on quantitative intrapartum assessment of maternal characteristics by means of an algorithmic method in low-risk women.

Methods
The derivation part (n = 200) prospectively explored 10 variables to create the best-fit algorithms (70% correct estimates within ±10% of actual BW) for prediction of BW at term; vertex presentation with engagement. The algorithm was then cross validated with samples of unrelated cases (n = 280) to compare the accuracy with the routine abdominal palpation method.

Results
The best-fit algorithms were parity-specific. The derived simplified algorithms were (1) BW (g) = 100 [(0.42 × symphysis-fundal height (SFH; cm)) + gestational age at delivery (GA; weeks) − 25] in nulliparous, and (2) BW (g) = 100 [(0.42 × SFH (cm)) + GA − 23] in multiparous. Cross validation showed an overall 69.3% accuracy within ±10% of actual BW, which exceeded routine abdominal palpation (60.4%) (P = 0.019). The algorithmic BW prediction was significantly more accurate than routine abdominal palpation in women with the following characteristics: BW 2500–4000 g, multiparous, pre-pregnancy weight <50 kg, current weight <60 kg, height <155 cm, body mass index (BMI) <18.5 kg/m2, cervical dilatation 3–5 cm, station <0, intact membranes, SFH 30–39 cm, maternal abdominal circumference (mAC) <90 cm, mid-upper arm circumference (MUAC) <25 cm and female gender of the neonates (P < 0.05).

Conclusion
An overall accuracy of term BW prediction by our simplified algorithms exceeded that of routine abdominal palpation.