bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loganin prevents BV‐2 microglia cells from Aβ1‐42‐induced inflammation via regulating TLR4/TRAF6/NF‐κB axis
Authors: Cui Yong , Wang Yanjie , Zhao Danyu , Feng Xiaofan , Zhang Lin , Liu Chun 
Published: October 2018

AbstractNeuroinflammation is closely related with the pathogenesis and progress of neurodegenerative diseases including Alzheimer's disease (AD). Loganin, an iridoid glycoside obtained from traditional Chinese medicine Cornus officinalis, has properties of inhibiting inflammation and improving memory. The present study was aimed to investigate effects of loganin on Aβ‐induced inflammation and to explore the underlying mechanisms. BV‐2 microglia cells were stimulated with 10 µM Aβ1‐42 for 24 h to induce inflammatory damage. According to results of CCK‐8 assay, the doses of loganin in present work were 10 and 30 µM. We found that treatment with loganin could inhibit Aβ1‐42‐induced microglia activation. Furthermore, loganin treatment prevented the over‐production of Tumor necrosis factor‐α (TNF‐α), Interleukin‐6 (IL‐6), Macrophage Chemotactic Protein 1(MCP‐1), Nitric oxide (NO), Prostaglandin E2 (PGE2) and the up‐regulation of inducible nitric oxide synthase (iNOS) and Cyclooxygenase 2 (COX‐2) in Aβ1‐42‐stimulated BV‐2 cells. Results from Western blots demonstrated that loganin inhibited Aβ1‐42‐induced elevation in Toll‐like receptor 4 (TLR4), Myeloid Differentiation Factor 88 (MyD88) and TNF receptor‐associated factor 6 (TRAF6). Loganin treatment also attenuated the increased phosphorylation level of IRAK4 caused by Aβ1‐42. Additionally, loganin alleviated nuclear translocation of NF‐κB p65 subunit in Aβ1‐42‐stimulated BV‐2 cells, and this phenomenon could be reversed by TLR4 agonist LPS. Further, the anti‐inflammatory effects of loganin were attenuated when TLR4 signaling pathway was re‐activated by LPS. Taken together, our data indicated that loganin could attenuate inflammatory response induced by Aβ in BV‐2 microglia cells, partially through deactivating the TLR4/TRAF6/NF‐κB axis.
IRGM promotes glioma M2 macrophage polarization through p62/TRAF6/NF‐κB pathway mediated IL‐8 production
Authors: Xu Yanwen , Liao Chuanpeng , Liu Renli , Liu Jing , Chen Zhongping , Zhao Huafu , Li Zongyang , Chen Lei , Wu Changpeng , Tan Hui , Liu Wenlan , Li Weiping 
Published: October 2018

AbstractAlternatively activated (M2) macrophage promotes glioma progression and immune escape as the most immunocyte in glioma microenvironment. Finding out the key protein regulating M2 macrophage polarization is necessary for improving treatment. Whether immunity related GTPase M (IRGM) is involved in glioma development and M2 macrophage polarization is unknown. IRGM and M2 macrophage marker CD206 expression were examined using immunohistochemistry among 35 glioma and 11 non‐cancerous brain specimens. We found IRGM scores were positively correlated with CD206 scores in glioma specimens and monocyte proportion in blood samples. A172 glioma cells transfected with either IRGM knock‐down lentivirus (Lenti‐IRGM) or control lentivirus (Lenti‐HK) were subcutaneously injected into nude mice. In vivo, xenografted glioma size of the Lenti‐IRGM group was smaller and had weaker fluorescence signal than Lenti‐HK control group. Immunofluorescence results showed that there was obviously decreased IRGM, CD206, and IL‐8 expression in the mice glioma of Lenti‐IRGM group than Lenti‐HK control group. In vitro, flow cytometry results showed that M2 polarization from THP‐1 cocultured with Lenti‐IRGM glioma cells decreased in contrast to that with Lenti‐HK glioma cells; there were less interleukin‐8 (IL‐8) and macrophage inflammation protein 3‐α (MIP‐3α), but more interleukin‐6 (IL‐6) in the supernatant of Lenti‐IRGM glioma cells than matched control. Western blot and immunofluorescence displayed that IRGM strongly promoted sequestosome‐1 (p62/SQSTM1), necrosis factor receptor‐activating factor 6 (TRAF6) expression and NF‐κB transportation to the nucleus. Realtime PCR results demonstrated IRGM also promoted NF‐κB downstream cytokines IL‐8 and MIP‐3α mRNA expression. These data suggested that IRGM could promote glioma development and M2 macrophage polarization by regulating p62/TRAF6/NF‐κB pathway‐mediated IL‐8 production.
Mesenchymal stem cells induced anti‐inflammatory features in B cells from breast tumor draining lymph nodes
Authors: Mehdipour Fereshteh , Razmkhah Mahboobeh , Rezaeifard Somayeh , Bagheri Mandana , Talei Abdol‐Rasoul , Khalatbari Behzad , Ghaderi Abbas 
Published: October 2018

AbstractThe immune‐modulatory effect of adipose‐derived stem cells (ASCs) on B cells in cancer has not been well elucidated. Herein, the interaction between B cells and ASCs isolated from the breast fat of either normal (nASCs) or breast cancer women (cASCs) was investigated. B cells derived from breast tumor draining lymph nodes were co‐cultured with nASCs or cASCs and B cells proliferation was assessed in direct and transwell assays. Moreover, B cells were co‐cultured with cASCs, nASCs or mesenchymal stromal cells of the tumor tissue (TSCs) and B cell cytokine production was assessed using flow cytometery. cASCs or TSCs were co‐cultured with either intact or B cell depleted lymphocytes and frequencies of CD25+FoxP3+ Tregs, IL‐10+ or IFN‐γ+CD4+ T cells were assessed. Results showed that co‐culture of B cells with ASCs in transwell chambers did not affect B cell proliferation. nASCs, however, was able to significantly reduce B cell proliferation in direct co‐culture experiments (P = 0.004). The frequencies of IL‐10+, TNF‐α+, IL‐2+, and IFN‐γ+ B cells were not significantly different in the co‐cultures of B cells with ASCs or TSCs. But the TNF‐α+/ IL‐10+ B cells ratio decreased in all co‐cultures, a reduction merely significant in B cell‐cASCs co‐culture (P = 0.01). The frequencies of CD4+ T cells subsets in either intact or B cell depleted lymphocytes did not undergo significant changes following co‐culture with ASCs or TSCs. Therefore, ASCs is capable of inhibiting B cell proliferation in a contact dependent manner and shifting the cytokine profile of B cells toward an anti‐inflammatory profile.
Transradial left gastric artery embolization to treat severe obesity: A pilot study
Authors: Pirlet Charles , Ruzsa Zoltan , Costerousse Olivier , Nemes Balázs , Merkely Béla , Poirier Paul , Bertrand Olivier F. 
Published: October 2018

AbstractBackgroundBariatric surgery is currently the only effective treatment with long‐lasting results to treat severe obesity.ObjectivesWe performed a pilot study to evaluate the feasibility, safety and efficacy of percutaneous distal embolization of the left gastric artery (LGA) using a transradial approach.Methods and ResultsWe recruited seven severely obese male patients (mean age 48 ± 7 years) referred for diagnostic coronary angiography. Mean baseline weight was 160 ± 27 kg and body mass index was of 52 ± 8 kg/m2. We successfully injected 300–500 μm polyvinyl alcohol particles using 5Fr catheters and all distal LGA were occluded at the end of procedures. Mean procedure duration was 24 ± 13 min and mean fluoroscopy time was 10 ± 5 min. Six patients reported mild transient epigastric discomfort, which resolved with proton pump inhibitors. At 2 months, the average weight loss was of 7 ± 6 kg (median loss: −10 kg [−2, −11]), 6 ± 12 kg (median loss: −9 kg [−16, +4]) at 6 months and 13 ± 17 kg (median loss: −11 kg [0, −25]) up to 12 months after index procedures.ConclusionPercutaneous transradial LGA embolization appears to be a promising technique to reduce the obesity burden. Randomized trials are required to further delineate the risk/benefit ratio, potential clinical indications and long term results.
A sentinel in Mitraclip intervention: Catch the enemy!
Authors: Calcagno Simone , Cimino Sara , Cerbelli Bruna , Sardella Gennaro 
Published: October 2018

AbstractCerebral ischemic lesions occurring during transcatheter valve interventions are common feared complications and the use of filter device seems to reduce their incidence. We report the case of an 84‐year old female patient with severe mitral regurgitation undergoing MitraClip. During the trans‐esophageal echocardiography (TEE)‐guided procedure was detected the presence of a little fibrin strand adherent to the steerable guide catheter for which we decided to implant the Claret CE Pro (Claret Medical, Inc. Santa Rosa, CA, USA) cerebral protection device and to continue the procedure during which the thrombus disappeared. At the end of the procedure a big thrombus was detected in the distal filter. The histologic analysis of the debris captured by the filters showed the presence of a thrombus, compatible with the image identified by TEE.
Gold Catalysts for the Selective Oxidation of Biomass‐Derived Products
Authors: Cattaneo Stefano , Stucchi Marta , Villa Alberto , Prati Laura 
Published: October 2018

AbstractBiomass constitutes a renewable source for new chemical platforms. Among other processes the catalytic ones represent a green alternative when active and selective catalysts can be developed. In this paper, applications of gold and gold‐based catalysts have been reviewed in the field of the selective oxidations. Indeed, from the discovery of the peculiarity of gold as catalytic material, the liquid phase oxidations have been differently viewed. Three important biomass‐derived molecules, namely glucose, hydroxymethyl furfural (HMF) and glycerol have been considered as precursors for products of industrial interest where gold catalysts have played an important role. This review starts from the research on monometallic gold catalysts which have been explored initially and then look at gold as modifier of other metal catalyst. This latter field is still in evolution and probably needs to be look at in the future.
Li1.1V0.9O2/C Microspheres with Isomeric Core‐Shell structure and their Improved Lithium Storage Performance for Lithium‐Ion Batteries
Authors: Feng Nanxiang , Xiang Kaixiong , Xiao Li , Chen Wenhao , Zhu Yirong , Chen Han 
Published: October 2018

AbstractLi1.1V0.9O2/C microspheres with isomeric core‐shell structure were synthesized by a rapid cooling and subsequent evaporative assembly approach. The prepared Li1.1V0.9O2/C microspheres were characterized by X‐ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM) including elemental mapping analysis, and transmission electron microscopy (TEM). The core‐shell Li1.1V0.9O2/C microspheres display identical composition but distinct texture of cores and shells, which herein is described as isomeric structure. Amorphous carbon nanodots are uniformly dispersed in the crystalline Li1.1V0.9O2 matrix in the core. In the shell however, Li1.1V0.9O2 nanoparticles are embedded in an amorphous carbon network. The Li1.1V0.9O2/C microspheres are tested as active material for anodes in lithium‐ion batteries, and exhibit an excellent reversible capacity of 295 mAh g−1, high capacity retention of 98 % after 100 cycles at 0.2 C and 95 % after 500 cycles at 2 C rate, and deliver wonderful rate capability of 250 mAh g−1 at 5 C. Thus, the Li1.1V0.9O2/C microspheres with isomeric core‐shell structure are promising candidates as anode material for commercial lithium‐ion batteries.
One‐Pot Solvothermal Synthesis of Molybdenum‐Tungsten Chalcogenide/Carbon Composite Electrodes for Asymmetric Supercapacitors
Authors: Huo Jinghao , Zhuo Ran , Xue Yujia , Guo Shouwu 
Published: October 2018

AbstractTwo‐dimensional (2D) transition‐metal chalcogenides exhibit excellent electrochemical properties in the energy storage field. We prepared molybdenum−tungsten chalcogenide/carbon (MWCC) hybrid nanosheets on nickel foams by using an one‐pot solvothermal synthesis. The unique 2D structure of the MWCC electrode is beneficial to ion and electron transportation. Furthermore, the MWCC electrode exhibits excellent electrochemical performance in terms of the electrical double‐layer capacitance and pseudocapacitance (1325.2 F g−1 at a current density of 1 A g−1). Experimental tests showed that the structure, morphology, and electrochemical properties of the MWCC electrode are favorable for high‐performance asymmetric supercapacitors with an active carbon (AC) negative electrode. The MWCC//AC device not only has a high specific capacitance (114.7 F g−1 at 1 A g−1), but also exhibit a high energy density of 40.8 Wh kg−1 at a power density of 799.1 W kg−1. Meanwhile, the MWCC//AC device maintains a capacitance retention of 89 % after 5000 cycles at 5 A g−1.
Panelists bias matrix estimation in a red wine trained panel: A potential tool for data pre‐treatment and feedback calibration
Authors: Diako Charles , Cooper Kevin D. , Ross Carolyn F. 
Published: October 2018

AbstractIn this study, panelists' bias in a trained wine sensory panel was abstracted as a linear operator to provide feedback to the panelists, to adjust (“filter”) evaluations and to predict attribute ratings of unknown samples. The bias matrix is a square matrix of attributes showing individual panelists intensity agreement with the entire panel average. Using this matrix to filter the original intensity ratings reduced the dispersion of ratings around the mean without significantly affecting the mean value. Predictively filtered means were closer to bias‐adjusted means than the un‐adjusted means.
A Porous Cobalt Tetraphosphonate Metal–Organic Framework: Accurate Structure and Guest Molecule Location Determined by Continuous‐Rotation Electron Diffraction
Authors: Wang Bin , Rhauderwiek Timo , Inge A. Ken , Xu Hongyi , Yang Taimin , Huang Zhehao , Stock Norbert , Zou Xiaodong 
Published: October 2018

AbstractSingle‐crystal electron diffraction has shown to be powerful for structure determination of nano‐ and submicron‐sized crystals that are too small to be studied by single‐crystal X‐ray diffraction. However, it has been very challenging to obtain high quality electron diffraction data from beam sensitive crystals such as metal–organic frameworks (MOFs). It is even more difficult to locate guest species in the pores of MOF crystals. Here, we present synthesis of a novel porous cobalt MOF with 1D channels, [Co2(Ni‐H4TPPP)]⋅2 DABCO⋅6 H2O, (denoted Co‐CAU‐36; DABCO=1,4‐diazabicyclo[2.2.2]octane), and its structure determination using continuous rotation electron diffraction (cRED) data. By combining a fast hybrid electron detector with low sample temperature (96 K), high resolution (0.83–1.00 Å) cRED data could be obtained from eight Co‐CAU‐36 crystals. Independent structure determinations were conducted using each of the eight cRED datasets. We show that all atoms in the MOF framework could be located. More importantly, we demonstrate for the first time that organic molecules in the pores, which were previously difficult to find, could be located using the cRED data. A comparison of eight independent structure determinations using different datasets shows that structural models differ only on average by 0.03(2) Å for the framework atoms and 0.10(6) and 0.16(12) Å for DABCO and water molecules, respectively.
Ligand Radicals as Modular Organic Electron Spin Qubits
Authors: McGuire Jake , Miras Haralampos N. , Donahue James P. , Richards Emma , Sproules Stephen 
Published: October 2018

AbstractThe intrinsic redox activity of the dithiolene ligand is presented here as the novel spin host in the design of a prototype molecular electron spin qubit, where the traditional roles of the metal and ligand components in coordination complexes are inverted. A series of paramagnetic bis(dithiolene) complexes with group 10 metals—nickel, palladium, platinum—provides a backdrop to investigate the spin dynamics of the organic ligand radical using pulsed EPR spectroscopy. The temperature dependence of the phase memory time (TM) is shown to be dependent on the identity of the diamagnetic metal ion, with the short times recorded for platinum a consequence of a diminishing spin‐lattice (T1) relaxation time driven by spin‐orbit coupling. The utility of the radical ligand spin center is confirmed when it delivers one of the longest phase memory times ever recorded for a molecular two‐qubit prototype.
Does a Conjugation Site Affect Transport of Vitamin B12–Peptide Nucleic Acid Conjugates into Bacterial Cells?
Authors: Wierzba Aleksandra J. , Maximova Ksenia , Wincenciuk Aleksandra , Równicki Marcin , Wojciechowska Monika , Nexø Ebba , Trylska Joanna , Gryko Dorota 
Published: October 2018

AbstractGram‐negative bacteria develop specific systems for the uptake of scarce nutrients, including vitamin B12. These uptake pathways may be utilized for the delivery of biologically relevant molecules into cells. Indeed, it was recently reported that vitamin B12 transported an antisense peptide nucleic acid (PNA) into Escherichia coli and Salmonella Typhimurium cells. The present studies indicate that the conjugation site of PNA to vitamin B12 has an impact on PNA transport into bacterial cells. Toward this end, a specifically designed PNA oligomer has been tethered at various positions of vitamin B12 (central Co, R5′‐OH, c and e amide chains, meso position, and at the hydroxy group of cobinamide) by using known or newly developed methodologies and tested for the uptake of the synthesized conjugates by E. coli. Compounds in which the PNA oligonucleotide was anchored at the R5′‐OH position were transported more efficiently than that of other compounds tethered at the peripheral positions around the corrin ring. Of importance is the fact that, contrary to mammalian organisms, E. coli also takes up cobinamide, which is an incomplete corrinoid. This selectivity opens up ways to fight bacterial infections.
Integration of an N‐Heterocyclic Carbene Precursor into a Covalent Triazine Framework for Organocatalysis
Authors: Troschke Erik , Nguyen Khoa Dang , Paasch Silvia , Schmidt Johannes , Nickerl Georg , Senkovska Irena , Brunner Eike , Kaskel Stefan 
Published: October 2018

AbstractThe successful incorporation of a thermally fragile imidazolium moiety into a covalent triazine framework resulted in a heterogeneous organocatalyst active in carbene‐catalyzed umpolung reaction. The structural integrity of the imidazolium moiety was confirmed by combining solid‐state NMR and XPS experiments.
A Supramolecular Palladium Catalyst Displaying Substrate Selectivity by Remote Control
Authors: Zardi Paolo , Roisnel Thierry , Gramage‐Doria Rafael 
Published: October 2018

AbstractInspired by enzymes such as cytochrome P‐450, the study of the reactivity of metalloporphyrins continues to attract major interest in the field of homogeneous catalysis. However, little is known about benefitting from the substrate‐recognition properties of porphyrins containing additional, catalytically relevant active sites. Herein, such an approach is introduced by using supramolecular ligands derived from metalloporphyrins customized with rigid, palladium‐coordinating nitrile groups. According to different studies (NMR and UV/Vis spectroscopy, XRD, control experiments), the supramolecular ligands are able to accommodate pyridine derivatives as substrates inside the porphyrin pocket while the reactivity occurs at the peripheral side. By simply tuning a remote metal center, different binding events result in different catalyst reactivity, and this enzyme‐like feature leads to high degrees of substrate selectivity in representative palladium‐catalyzed Suzuki–Miyaura reactions.
Catalyst‐Free Oxytrifluoromethylation of Alkenes through Paired Electrolysis in Organic‐Aqueous Media
Authors: Jud Wolfgang , Kappe C. Oliver , Cantillo David 
Published: October 2018

AbstractA mild, catalyst‐free electrochemical oxytrifluoromethylation of alkenes has been developed. The procedure is based on the paired electrolysis of sodium triflinate and water in an undivided cell. Anodic oxidation of the triflinate anion generates trifluoromethyl radicals that react with the alkene. Water plays a dual role as oxidant for the cathode and nucleophile. The method has been utilized to prepare a diverse set of 1‐hydroxy‐2‐trifluoromethyl compounds in moderate to excellent yields (27–94 %). Alcohols have also been tested as nucleophiles for this versatile method with moderate yields. Facile recycling of the electrolyte has been demonstrated, and application of electricity avoids the use of stoichiometric amounts of oxidizers in a safe and environmentally benign reaction.
Neue Ansätze zur Differenzierung im Schülerlabor
Authors: Affeldt Fiona , Siol Antje , Markic Silvija , Eilks Ingo 
Published: October 2018

AbstractDie Herausforderung, auf eine zunehmend heterogene Schülerschaft zu reagieren, ist nicht nur eine Aufgabe von Schule. Da naturwissenschaftliche Bildung verstärkt auch in der Kooperation von Schulen und außerschulischen Bildungsträgern stattfinden sollte, stellen sich Fragen etwa an Schülerlabore, ob und wie diese der zunehmenden Heterogenität ihrer Besucherinnen und Besucher begegnen. Dieser Beitrag diskutiert Ansätze zur Differenzierung im Schülerlabor für besonders heterogene Lerngruppen. Es werden ein Modell und verschiedene Maßnahmen zur Differenzierung im Schülerlabor vorgestellt. Ergebnisse aus der Evaluation deuten an, dass das Differenzierungsmodell für das Schülerlabor gut einsetzbar ist und die verwendeten Methoden, u.a. durch Comics unterstütze Versuchsanleitungen und abgestufte Lernhilfen, auf große Zustimmung bei den Lernenden stoßen
What do transplant physicians think about palliative care? A national survey study
Authors: El‐Jawahri Areej , LeBlanc Thomas W. , Burns Linda J. , Denzen Ellen , Meyer Christa , Mau Lih‐Wen , Roeland Eric J. , Wood William A. , Petersdorf Effie 
Published: October 2018

BackgroundDespite its established benefits, palliative care (PC) is rarely utilized for hematopoietic stem cell transplant (HSCT) patients. We sought to examine transplant physicians’ perceptions of PC.MethodsWe conducted a cross‐sectional survey of transplant physicians recruited from the American‐Society‐for‐Blood‐and‐Marrow‐Transplantation. Using a 28‐item questionnaire adapted from prior studies, we examined physicians’ access to PC services, and perceptions of PC. We computed a composite score of physicians’ attitudes about PC (mean = 16.9, SD = 3.37) and explored predictors of attitudes using a linear mixed model.Results277/1005 (28%) of eligible physicians completed the questionnaire. The majority (76%) stated that they trust PC clinicians to care for their patients, but 40% felt that PC clinicians do not have enough understanding to counsel HSCT patients about their treatments. Most endorsed that when patients hear the term PC, they feel scared (82%) and anxious (76%). Nearly half (46%) reported that the service name ‘palliative care’ is a barrier to utilization. Female sex (β = 0.85, P = .024), having <10 years of clinical practice (β = 1.39, P = .004), and perceived quality of PC services (β = 0.60, P < .001) were all associated with a more positive attitude towards PC. Physicians with a higher sense of ownership over their patients’ PC issues (β = ‐0.36, P < .001) were more likely to have a negative attitude towards PC.ConclusionsThe majority of transplant physicians trust PC, but have substantial concerns about PC clinicians’ knowledge about HSCT and patients’ perception of the term ‘palliative care’. Interventions are needed to promote collaboration, improve perceptions, and enhance integration of PC for HSCT recipients.