bluuebunny/crossref_metadata_2025_split huggingface dataset:
TMT‐Based Quantitative Proteomic Analysis Reveals Proteomic Changes Involved in Longevity
Authors: Wang Zongkui , Zhang Rong , Liu Fengjuan , Jiang Peng , Xu Jun , Cao Haijun , Du Xi , Ma Li , Lin Fangzhao , Cheng Lu , Zhou Xuefeng , Shi Zhihui , Liu Yeheng , Huang Yaojing , Ye Shengliang , Li Changqing 
Published: November 2018

PurposeIndividual lifespans vary widely, and longevity is the main concern from ancient to modern times. This study is aimed to identify plasma proteins associated with longevity by proteomics technique.Experimental designTandem mass tags (TMT)‐based proteomics analysis is performed for the plasma of Bama longevity group and a control group to analyze the differentially expressed proteins (DEPs). A validation set is used to verify the results of TMT‐based proteomics.ResultsBetween Bama natives and the control individuals, the authors identify 175 DEPs, which are mainly involved in complement and coagulation cascades, metabolism of glyco and lipid, and regulation of actin cytoskeleton. Consistent with the proteomic analysis, plasma levels of MMP2, CCL5, and PF4 are significantly lower in Bama participants than in controls, whereas IGFBP2 and C9 increase in Bama individuals, in the validation set. By ROC analysis, combinations of these five proteins result in a high AUC value (0.991, 95% CI, 0.929–1.000, p < 0.0001) to distinguish longevous participants from controls.Conclusions and clinical relevanceThe results highlight the roles of complement and coagulation cascades, metabolism of glyco and lipid, and inflammatory and immune response may play important roles in longevity. And the DEPs may serve as clinically useful biomarkers for healthy aging and predicting longevity.
iTRAQ‐Based Quantitative Proteomics Approach Identifies Novel Diagnostic Biomarkers That Were Essential for Glutamine Metabolism and Redox Homeostasis for Gastric Cancer
Authors: Jiang Zhen , Zhang Chenghua , Gan Li , Jia Yuewang , Xiong Yu , Chen Yujiang , Wang Zhi , Wang Linfeng , Luo Hao , Li Juexi , Zhu Rui , Ji Xingli , Yu Qin , Wang Li 
Published: November 2018

PurposeTo screen the novel biomarkers for gastric cancer and to determine the values of glutaminase 1 (GLS1) and gamma‐glutamylcyclotransferase (GGCT) for detecting gastric cancer.Experimental designA discovery group of four paired gastric cancer tissue samples are labeled with Isobaric tag for relative and absolute quantitation agents and identified with LC‐ESI‐MS/MS. A validation group of 168 gastric cancer samples and 30 healthy controls are used to validate the expression of GLS1 and GGCT.ResultsFour hundred and thirty‐one proteins are found differentially expressed in gastric cancer tissues. Of these proteins, GLS1 and GGCT are found overexpressed in gastric cancer patients, with sensitivity of 75.6% (95% CI: 69–82.2%) and specificity of 81% (95% CI: 75–87%) for GLS1, and with sensitivity of 63.1% (95% CI: 55.7–71.5%) and specificity of 60.7% (95% CI: 53.3–68.2%) for GGCT. The co‐expression of GLS1 and GGCT in gastric cancer tissues has sensitivity of 78.1% (95% CI: 70.1–86.1%) and specificity of 86.5% (95% CI: 79.5–93.4%). Moreover, both GLS1 and GGCT present higher expression of 82.6% (95% CI: 68.5–99.4%) and 73.9% (95% CI: 54.5–93.3%) in lymph node metastasis specimen than those in non‐lymph node metastasis specimen. The areas under ROC curves are up to 0.734 for the co‐expression of GLS1 and GGCT in gastric cancer. The co‐expression of GLS1 and GGCT is strongly associated with histological grade, lymph node metastasis, and TNM stage Ⅲ/Ⅳ.Conclusions and clinical relevanceThe present study provides the quantitative proteomic analysis of gastric cancer tissues to identify prognostic biomarkers of gastric cancer. The co‐expression level of GLS1 and GGCT is of great clinical value to serve as diagnostic and therapeutic biomarkers for early gastric cancer.
The Effects of Confinement on the Fracturing Performance of Printed Nanothermites
Authors: Westphal Eric R. , Murray Allison K. , McConnell Miranda P. , Fleck Trevor J. , Chiu George T.‐C. , Rhoads Jeffrey F. , Gunduz I. Emre , Son Steven F. 
Published: November 2018

AbstractNanothermites have shown the potential to controllably fracture substrates in applications such as electromechanical systems security. In prior work, both equivalence ratio and material formulation have been varied to tailor fracturing performance. In this paper, material confinement was utilized to further tailor the fracturing performance of aluminum bismuth (III) oxide (Al/Bi2O3) and aluminum copper (II) oxide (Al/CuO) nanothermites. These nanothermites were selectively deposited onto representative substrates through inkjet printing. Al/Bi2O3 nanothermites were prepared over a range of equivalence ratios and showed a range of resulting fragmentation, with a maximum near the equivalence ratio of ϕ=2. Burning rate measurements correlated with the trends seen in these experiments. All of the previous attempts at fragmenting a substrate using unconfined Al/CuO were unsuccessful. The prepared Al/CuO nanothermites at stoichiometric conditions resulted in fractured silicon substrates when confined. These results demonstrate the ability of confinement to further tailor the fracturing performance of nanothermites.
Translation and psychometric evaluation of the Hebrew version of the Health Care Providers' Pain and Impairment Relationship Scale
Authors: Roitenberg Neta 
Published: November 2018

AbstractBackground and purposePhysiotherapists' different attitudes towards low back pain (LBP) are associated with patients' attitudes towards pain and with patients' disability. The Health Care Providers' Pain and Impairment Relationship Scale (HC‐Pairs) is a self‐administered instrument that assesses the attitudes and beliefs of health care professionals regarding LBP and the patient's daily function. The aims of this study are to translate, culturally adapt, and asses the psychometric properties of the Hebrew version of the HC‐Pairs.MethodsThe English version of the HC‐Pairs was forward–backward translated, pretested, and reviewed by a panel of experts. Reliability was determined by computing Cronbach's α, and validity by exploring the correlations between the HC‐Pairs' scores and the Pain Attitudes and Beliefs Scale for Physiotherapists (PABS‐PT) scores. Confirmatory factor analysis was performed. A convenience sample of 277 physiotherapists was invited to fill the HC‐Pairs and PABS‐PT questionnaires and a sociodemographic questionnaire.ResultsThe forward–backward translation process revealed minor discrepancies between the texts. After the pretest, the expert panel agreed on a final version. A sample of 241 physiotherapists completed the questionnaires (response rate of 87%; 241/277); 213 met the inclusion criteria. Factor analysis suggests that the Hebrew version of the scale fits the one‐factor model. Cronbach's α was 0.81 after deletion of two items and indicated good internal consistency. The scores produced by the instrument showed a substantial correlation with those of the biomedical dimension of the PABS‐PT, and poor correlation with the behavioural dimension, in the expected directions.ConclusionThe findings of the present study on the psychometric properties of the HC‐Pairs are positive. Nevertheless, the Hebrew version of the HC‐Pairs is still in a developmental stage. Further psychometric research is needed to assess the attitudes and beliefs of Hebrew‐speaking physiotherapists, which have been shown to be associated with treatment orientations and work recommendations.
An innovative feature selection method for support vector machines and its test on the estimation of the credit risk of default
Authors: Sariev Eduard , Germano Guido 
Published: November 2018

AbstractSupport vector machines (SVM) have been extensively used for classification problems in many areas such as gene, text and image recognition. However, SVM have been rarely used to estimate the probability of default (PD) in credit risk. In this paper, we advocate the application of SVM, rather than the popular logistic regression (LR) method, for the estimation of both corporate and retail PD. Our results indicate that most of the time SVM outperforms LR in terms of classification accuracy for the corporate and retail segments. We propose a new wrapper feature selection based on maximizing the distance of the support vectors from the separating hyperplane and apply it to identify the main PD drivers. We used three datasets to test the PD estimation, containing (1) retail obligors from Germany, (2) corporate obligors from Eastern Europe, and (3) corporate obligors from Poland. Total assets, total liabilities, and sales are identified as frequent default drivers for the corporate datasets, whereas current account status and duration of the current account are frequent default drivers for the retail dataset.
Robust observer‐based output feedback controller for nonlinear systems with uncertain triangular and nontriangular nonlinearities and diagonal terms
Authors: Oh Sang‐Young , Choi Ho‐Lim 
Published: November 2018

SummaryIn this paper, we provide a robust observer‐based output feedback control scheme for a class of nonlinear systems where there are uncertain triangular and nontriangular nonlinearities, nontrivial diagonal terms, and external disturbance. The presence of diagonal terms is the main generalized feature over the existing results. In order to handle the diagonal terms, there is a gain‐scaling factor in the proposed controller. Through the analysis, we show that all states and observer errors of the controlled system remain bounded. Moreover, the ultimate bounds of some states and observer errors can be made (arbitrarily) small by adjusting the gain‐scaling factor reflecting on the structure of nonlinearities and external disturbance. The validity of our control scheme is experimentally verified via the ball position control of an electromagnetic levitation system.
Sustainable development and architectural practice: Framing strategic approaches in the United Kingdom
Authors: Grover Robert , Emmitt Stephen , Copping Alexander 
Published: November 2018

AbstractThe concept of sustainability is widely accepted in the design of the built environment; however, in architectural practice, there exist multiple, often competing, interpretations and agendas. This research analyses this variety and develops a unique framework that reveals actual and potential paths for sustainable design. In‐depth interviews were conducted with 24 high‐profile sustainable architecture practices in the United Kingdom. The data reveal a range of sustainable practice, which is grouped into consistent strategies. This forms the basis of an original evaluative framework that classifies alternative approaches providing a means to contextualise different, yet equally valid, design scenarios. The findings reconceptualise sustainable design paradigms and reveal new opportunities for enhancing practice. This has implications for professional organisations, who are able to shape practice through recognised standards, as well as designers themselves. It also has significance for the education of architects who are able to explore new avenues for sustainable design.
Monoalkylated Cyclen Complexes for Efficient Proteolysis: Influence of Donor Atom Exchange
Authors: Hinojosa Sebastián , Weise Christoph , Albold Uta , Kulak Nora 
Published: November 2018

AbstractMetal complexes of cyclen have been widely used to hydrolytically cleave biomolecules (proteins, RNA, DNA) and model substrates. Such cleavage reactions, however, usually require a high pH, long incubation times and enhanced temperatures. The present study combines two straightforward approaches to increase the proteolytic cleavage activity of cyclen complexes: alkylation in order to improve interactions with hydrophobic domains of proteins as well as single and double heteroatom exchange in order to increase the Lewis acidity of the metal center, in this case Cu(II). This allows reactions with BSA and Mb as model proteins to be carried out also at near‐physiological conditions. A Cu(II) complex with an alkylated oxacyclen ligand was identified as the most efficient species. Furthermore, a dioxacyclen derivative was investigated in proteolytic reactions for the first time.
Copper‐Catalyzed Coupling Reactions of Aryl Halides and Phenols by 4,4’‐Dimethoxy‐2,2’‐bipyridine and 4,7‐Dimethoxy‐1,10‐phenanthroline
Authors: Zhao Yingying , Wang Xiangyong , Kodama Koichi , Hirose Takuji 
Published: November 2018

AbstractSeveral Cu(I) complexes of 2,2’‐bipyridines were studied for the catalytic coupling of aryl iodides and phenols and 4,4’‐dimethoxy‐2,2’‐bipyridine was shown to be an effective ligand of CuI in 1:2 (CuI:ligand) ratio for the synthesis of a wide range of diaryl ethers (up to 97% yield) using K3PO4 as base in DMF at 100 °C. The catalysis was highly dependent on the reaction temperature and was successfully applied in the coupling with more attractive and challenging substrates, aryl bromides, at 140 °C in good‐to‐excellent yields (78−95%). Moreover, the heteroaromatic effect for the reaction was studied and gave a comparable result with phenyl group (up to 95% yield). Significantly, a structurally related N,N‐bidentate ligand, 4,7‐dimethoxy‐1,10‐phenanthroline, exhibited better performance for less‐reactive combinations of aryl halides and phenols.
Environmentally Benign Neat Mechanochemical Synthesis and Photophysical Studies of Indolylquinolines via Silica gel Catalyzed Metal free A3‐Coupling
Authors: Yadav Chandragiri Suresh , Suhasini Ramalingam , Thiagarajan Viruthachalam , Velmurugan Devadasan , Kannadasan Sathananthan 
Published: November 2018

AbstractAn efficient neat mechanochemical method for the synthesis of fluorescent indolylquinonlines via A3‐coupling reaction of 1‐phenylsulfonylindole‐3‐carbaldehyde (1), substituted anilines 2(a–j) and substituted phenylacetylene 3(a,b) using SiO2 as an effective catalyst has been developed. The photophysical properties of newly synthesized indolylquinoline derivatives 4(a–l) were established and it depends on the nature of substituent at C6 position of quinoline moiety.
The evolution of RNA structural probing methods: From gels to next‐generation sequencing
Authors: Mailler Elodie , Paillart Jean‐Christophe , Marquet Roland , Smyth Redmond P. , Vivet‐Boudou Valerie 
Published: November 2018

RNA molecules are important players in all domains of life and the study of the relationship between their multiple flexible states and the associated biological roles has increased in recent years. For several decades, chemical and enzymatic structural probing experiments have been used to determine RNA structure. During this time, there has been a steady improvement in probing reagents and experimental methods, and today the structural biologist community has a large range of tools at its disposal to probe the secondary structure of RNAs in vitro and in cells. Early experiments used radioactive labeling and polyacrylamide gel electrophoresis as read‐out methods. This was superseded by capillary electrophoresis, and more recently by next‐generation sequencing. Today, powerful structural probing methods can characterize RNA structure on a genome‐wide scale. In this review, we will provide an overview of RNA structural probing methodologies from a historical and technical perspective.This article is categorized under:

RNA Structure and Dynamics > RNA Structure, Dynamics, and Chemistry
RNA Methods > RNA Analyses in vitro and In Silico
RNA Methods > RNA Analyses in Cells
Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers
Authors: Masuda Kiyoshi , Kuwano Yuki 
Published: November 2018

Gene expression patterns in cancer cells are strongly influenced by posttranscriptional mechanisms. RNA‐binding proteins (RBPs) play key roles in posttranscriptional gene regulation; they can interact with target mRNAs in a sequence‐ and structure‐dependent manner, and determine cellular behavior by manipulating the processing of these mRNAs. Numerous RBPs are aberrantly deregulated in many human cancers and hence, affect the functioning of mRNAs that encode proteins, implicated in carcinogenesis. Here, we summarize the key roles of RBPs in posttranscriptional gene regulation, describe RBPs disrupted in cancer, and lastly focus on RBPs that are responsible for implementing cancer traits in the digestive tract. These evidences may reveal a potential link between changes in expression/function of RBPs and malignant transformation, and a framework for new insights and potential therapeutic applications.This article is categorized under:
RNA in Disease and Development > RNA in Disease
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Irrigation Water Quality
Authors: Zaman Mohammad , Shahid Shabbir A. , Heng Lee 
Published: November 2018

AbstractThe quality of irrigation waters differs in various regions, countries and locations based on how the groundwater has been extracted and used, the rainfall intensity and subsequent aquifer recharge. The use of groundwater for agriculture in hot arid countries where rainfall is scarce leads to increase groundwater salinity and limits the selection of crops for cultivation. It is therefore important to determine the irrigation water quality. The concentration and composition of soluble salts in water determines its quality for irrigation. Four basic criteria for evaluating water quality for irrigation purposes are described, including water salinity (EC), sodium hazard (sodium adsorption ratio-SAR), residual sodium carbonates (RSC) and ion toxicity. Toxicities of boron and chlorides to plants are described. More specifically the relative tolerance levels of plants to boron is tabulated for easy understanding. The most important part of this chapter is the modification of water quality diagram of US Salinity Laboratory Staff published in the year 1954, this diagram does not present EC over 2250 μS cm-1, however, most of the irrigation waters present salinity levels higher than 2250 μS cm−1. Therefore, to accommodate higher water salinity levels the water classification diagram is extended to water salinity of 30,000 μS cm−1 allowing the users of the diagram to place EC values above 2250 μS cm−1. The salinity and sodicity classes are included in this chapter to provide information for crop selection and develop salinity and sodicity management options. The procedures for water salinity reduction through blending of different waters and management of water sodicity using gypsum are described by giving examples.
Discovery of caerulomycin/collismycin-type 2,2′-bipyridine natural products in the genomic era
Authors: Chen Dandan , Zhao Qunfei , Liu Wen 
Published: November 2018

Abstract
2,2′-Bipyridine (2,2′-BP) is the unique molecular scaffold of the bioactive natural products represented by caerulomycins (CAEs) and collismycins (COLs). CAEs and COLs are highly similar in the chemical structures in which their 2,2′-BP cores typically contain a di- or tri-substituted ring A and an unmodified ring B. Here, we summarize the CAE and COL-type 2,2′-BP natural products known or hypothesized to date: (1) isolated using methods traditional for natural product characterization, (2) created by engineering the biosynthetic pathways of CAEs or COLs, and (3) predicted upon bioinformatics-guided genome mining. The identification of these CAE and COL-type 2,2′-BP natural products not only demonstrates the development of research techniques and methods in the field of natural product chemistry but also reflects the general interest in the discovery of CAE and COL-type 2,2′-BP natural products.
REJOINDER TO JONATHAN SMITH, RESEARCH NOTE ON SHUN 舜
Authors: Smith Adam D. 
Published: November 2018

AbstractIn his Research Note, “Shun 舜 and the Interpretation of Early Orthographical Variation,” in this issue of Early China, Jonathan Smith made several claims about the early evolution of the graph 舜, in particular suggesting that it should be identified with the graph lin 粦 that occurs in certain Western Zhou bronze inscriptions. While showing that these claims are ill-supported, I nevertheless concur in the identification with the bronze-inscriptional graph, but show that the word being written is 濬 ~ 浚 “deep, profound” and in no way connected with lin 粦.
HISTORY AS FUTURE—TIME, PREDICTION, AND HISTORICAL NARRATIVE IN THE ZUO ZHUAN
Authors: Gibas Piotr 
Published: November 2018

AbstractThis article demonstrates that historical narrative in the Zuo zhuan is founded on the concept of “timeliness,” that is, on the understanding of time as being endowed with moral qualities. The choice between a “timely” (shi 時) or “untimely” (bu shi 不時) course of action determines the success or failure of the person involved in it. The origins of the ideas of time that shape the historical narrative of Zuo zhuan can be traced to mantic literature of the same period, such as almanacs.Early Chinese writers of history—like diviners—strove to explain the past in order to predict the future. Seen in this light, “knowing history” implies understanding and mastering the mechanisms that drive it; and looking into the past is tantamount to “knowing” the future.
Numerical modelling of supersonic boundary-layer receptivity to solid particulates
Authors: Chuvakhov Pavel V. , Fedorov Alexander V. , Obraz Anton O. 
Published: November 2018

Atmospheric particulates may be a major source of boundary-layer instabilities leading to laminar–turbulent transition on aerodynamically smooth bodies flying at supersonic speeds. Particulates penetrating into the boundary-layer flow can excite wavepackets of the first- and/or second-mode instability. The packets grow downstream, reach the threshold amplitude and ultimately break down to turbulent spots. A numerical model is developed to simulate excitation of unstable wavepackets by spherical solid particulates. As an example, computations are carried out for a $14^{\circ }$ half-angle sharp wedge flying at an altitude of 20 km, Mach number 4 and zero angle of attack. The numerical results agree satisfactorily with the theory developed by Fedorov (J. Fluid Mech., vol. 737, 2013, pp. 105–131). The numerical model opens up an opportunity to investigate receptivity to particulates for practical supersonic and hypersonic configurations such as blunt bodies of revolution.
AT THE TIPPING POINT? AL-AZHAR’S GROWING CRISIS OF MORAL AUTHORITY
Authors: Bano Masooda 
Published: November 2018

AbstractRoutinely required to lend religious legitimacy to contentious state policies, al-Azhar's moral authority has been under pressure since its nationalization in 1961. This article outlines how Shaykh al-Azhar Ahmad al-Tayyib's recent alliance with President ʿAbd al-Fattah al-Sisi has, however, exposed al-Azhar's moral authority to unprecedented risks. This is for three reasons. First, the tactics used by al-Sisi's government to quell the Muslim Brotherhood have been more extreme than those used by previous regimes. Second, the al-Azhari establishment's defence of these violent tactics has been more unqualified than in the past. Third, current state-led reforms of al-Azhar's curriculum are more controversial than prior efforts along these lines. As I show, these recent developments are not a complete break from the past; rather, they are a natural outcome of incremental shifts that have been occurring within al-Azhar since its nationalization over fifty years ago.