bluuebunny/crossref_metadata_2025_split huggingface dataset:
Body mass index and penile cancer incidence: results from a Norwegian cohort study of 829,081 men
Authors: Aune Dagfinn , Nordsletten Marie , Myklebust Tor Åge , Robsahm Trude Eid , Skålhegg Bjørn Steen , Mala Tom , Yaqub Sheraz , Saeed Usman 
Published: November 2024

Abstract
Background
A few previous studies have suggested a possible association between adiposity and increased risk of penile cancer, however, the evidence is to date limited for this rare cancer. We investigated the association between body mass index (BMI) and penile cancer risk in a large Norwegian cohort.

Methods
The analyses included 829,081 men aged 16–75 years at baseline in 1963–1975. Multivariable Cox regression analyses were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between BMI and penile cancer incidence.

Results
A total of 725 incident penile cancer cases occurred during 25.6 million person-years of follow-up. Compared to men with BMI 18.5-<25, the HRs (95% CIs) of those with a BMI of 15-<18.5, 25-<30, and ≥ 30 were 0.45 (0.15–1.41), 1.14 (0.97–1.33) and 1.63 (1.20–2.22), respectively, and the HR was 1.26 (1.12–1.42) per 5 kg/m2 increase in BMI. When the obese category was further subdivided in grade 1 (BMI 30-<35) and grade 2 obesity (≥ 35), the respective HRs were 1.52 (1.10–2.10) and 3.28 (1.46–7.35, ptrend<0.001). The positive association persisted in sensitivity analyses excluding the first 5 years of follow-up. The association between BMI in early adulthood and penile cancer risk was less precise (1.23, 0.91–1.65 per 5 kg/m2, n = 143 cases) and for BMI and early-onset penile cancer was null (1.03, 0.51–2.06 per 5 kg/m2, n = 27 cases).

Conclusion
High BMI is associated with increased risk of penile cancer. Further studies are needed to investigate the potential underlying mechanisms.
Comparing paper-based and mobile application for rank-based peer assessment in interprofessional education: before, during, and after the COVID-19 pandemic
Authors: Widyandana Doni , Utomo Prattama Santoso , Setiawan Ide Pustaka , Kurniawati Yustina Tyas , Dandekar Sucheta 
Published: November 2024

Abstract
Background
Education was affected during the COVID-19 pandemic, and there was a need to adapt the learning approaches to the situation. At the University of Gadjah Mada, many essential soft skills of healthcare professionals are taught using the interprofessional education (IPE) approach on-site. Our university responded to this crisis by offering online classes and similar types of training. Post-administration of the course, a peer-assessment was conducted, and it was used to provide feedback on the work or performance of peers among students. Peer assessment was done using paper-based and a mobile application during COVID-19. This study aimed to share a best practice for the implementation of a rank-based peer-assessment application for longitudinal interprofessional education in the community setting and to compare the score distribution of a rank-based peer-assessment before and after using mobile application.

Methods
Quantitative research design was used by processing secondary data on student peer assessment scores from 3 bachelor programs (medicine, nursing, nutritionist) Community and Family Health Care with Interprofessional Education (CFHC-IPE) in Faculty of Medicine, Nursing, and Public Health, Universitas Gadjah Mada. 4,790 students from 2018 to 2022 (5 years) were tracked before, during, and after the COVID-19 pandemic. The assessments carried out were offline, online, and blended learning, respectively. The assessment was carried out using a paper-based method before and during the pandemic, online-based with a mobile application was used. Thus, the peer-assessment was conducted manually or using paper-based method using a 5-rank scoring system. In 2019, the peer assessment was carried out using a mobile application and applied a 10-rank scoring system.

Results
The rank-based peer assessment can be well implemented to make students assess their friends more objectively, with an average score 82.02 ± 8.68. The rightward shift in the distribution of scores indicates that the average score has improved after using the mobile application compared to before its use. (82.02 ± 8.68 vs. 62.39 ± 11.13, p < 0.05).

Conclusion
The implementation of rank-based peer-assessment using a mobile application was well received during and after the pandemic by interprofessional undergraduate students. The online system made the assessment more objective and the average grades were seen to be better.
Prevalence of imposter syndrome and its association with depression, stress, and anxiety among nursing students: a multi-center cross-sectional study
Authors: El-Ashry Ayman Mohamed , Taha Samah Mohamed , Elhay Eman Sameh Abd , Hammad Heba Abdel-Hamid , Khedr Mahmoud Abdelwahab , El-Sayed Mona Metwally 
Published: November 2024

Abstract
Objective
To examine the prevalence of imposter syndrome among nursing students and its association with depression, stress, and anxiety.

Methods
A multi-center cross-sectional survey was conducted with 1572 nursing students randomly selected from three universities across Egypt. The study was conducted over 3 months, from the beginning of January to the end of March, during the academic year 2023/2024. Clance Imposter Phenomenon Scale and Depression Anxiety Stress Scale-21 were used for data collection.

Results
A significant proportion of nursing students experience moderate to highly severe levels of depression, anxiety, and stress. Around a quarter of students had moderate depression, 22.6% had moderate anxiety, and 14.9% had severe anxiety. Additionally, 13.3% of participants experienced severe stress, with only 3.8% experiencing highly severe stress. The study also found that 46.3% of students experienced moderate imposter syndrome, with 33% having frequent imposter levels and 6.2% scoring intense imposter on the scale. Furthermore, imposter syndrome was positively correlated with depression, anxiety, and stress, and the total score of the Depression Anxiety Stress Scale (r = 0.639, p < 0.001). The stepwise linear regression analysis explained that 45.0% of the variance in students' depression, anxiety, and stress was due to imposter syndrome and other sociodemographic covariates.

Conclusion
This study highlighted the relationship between imposter syndrome, depression, anxiety, and stress among nursing students. Specifically, female students in higher academic years, with lower grade point averages, living in urban areas, with lower family incomes, and not participating in hobbies are more prone to depression, anxiety, and stress.

Nursing implications
These findings underscore the need for a holistic approach to managing the complex nature of mental health among nursing students. Incorporating education and resources on self-care and stress management techniques into nursing training programs is imperative for addressing the implications of imposter syndrome in nursing practice. Equipping nursing students with these essential skills can enhance their resilience, foster a healthier work environment, and ultimately improve patient care outcomes.
Two cases of type I sialidosis and a literature review
Authors: Ding Yuan , Cheng Ming , Gong Chunxiu 
Published: November 2024

Abstract
Objective
This study aims to compare the clinical and electrophysiological characteristics of two cases of type I sialidosis in Chinese children with those reported in prior literature. The goal is to elucidate the clinical and genetic features of type I sialidosis.

Methods
Clinical investigations and genetic analyses were conducted on an 11-year-old girl, primarily presenting with short stature, who was admitted in June 2020, and a 10-year-old boy, admitted in July 2023, exhibiting rapid weight gain and accompanying visual impairment as primary manifestations. A literature review was performed by summarizing data from 31 published articles encompassing 69 genetically confirmed cases of type I sialidosis up to 2023 for comparative analysis.

Results
Patient 1 exhibited short stature, self-reported poor night vision, a history of occasional febrile seizures, mild scoliosis, bilateral cherry-red spots in the fundus, and prolonged P100 latency in both eyes as observed in visual evoked potentials (VEP). Genetic analysis revealed that she carried compound-heterozygous variants c.239 C > T (p.P80L) and c.880 C > T (p.R294C) in the NEU1 gene, inherited from her parents. Patient 2 presented with rapid weight gain and visual impairment, bilateral cherry-red spots in the fundus, abnormal neuroepithelial layer reflexes in both macular areas, approximately normal P100 latency but severely reduced amplitude in VEP after pupillary dilation, and severe bilateral optic nerve conduction block with relatively normal retinal cell function. Compound-heterozygous variants c.239 C > T (p.P80L) and c.803 A > G (p.T268C) were identified in the NEU1 gene of the Patient 2, inherited from his parents. By combining the cases reported in 31 literature articles with the 2 cases in our study, a total of 71 type I sialidosis patients were analyzed. The most common symptoms observed were muscle spasms (91.5%), followed by ataxia (75%) and seizures (63.6%). Intellectual impairment and abnormal electroencephalograms were more prevalent in Caucasian patients. Additionally, abnormal somatosensory evoked potentials, large cortical waves, and prolonged latency of VEP were more frequently observed in both Asian and Caucasian patients, serving as alternative indicators for early diagnosis.

Conclusion
NEU1 gene analysis provides essential guidance for genetic counseling and prenatal diagnosis. The exon 2 variant c.239 C > T (p.P80L) in the NEU1 gene may represent a mutation hotspot among Chinese patients.
I can’t feel your face: callous-unemotional traits, social anxiety, and approach-avoidance behaviour in conduct disorder
Authors: Derks Laura M. , Becker Eni S. , Rinck Mike , Holtmann Martin , Legenbauer Tanja , Lange Wolf-Gero 
Published: November 2024

Abstract
Background and objectives
Conduct disorders are associated with deficits in interpersonal behaviour. Both, callous-unemotional traits and social anxiety are often elevated in patients with conduct disorder and are associated with aggressive approach or disproportional avoidance. Previous studies have focused mainly on questionnaire reports of interpersonal behaviour, whereas direct explicit and implicit interpersonal behaviour in social contexts has not been considered sufficiently. Therefore, explicit and implicit interpersonal behaviour were investigated in children and adolescents with conduct disorder in the current study.

Methods
Forty male adolescent inpatients with conduct disorder and 30 typically developing controls (Mage = 12.5, SD = 1.39) took part in a virtual reality task in which they approached virtual agemates, displaying different facial expressions under the pretext of a cover story while interpersonal distance and walking speed were assessed (indirect condition). In addition, they were asked to move to a comfortable distance for conversation toward the agent (direct condition). Callous-unemotional traits and social anxiety were assessed via questionnaires.

Results
In the indirect condition, no differences between the groups emerged. In the direct condition, typically developing children adjusted their interpersonal distance to the respective expression that the virtual classmate displayed. They showed significantly greater interpersonal distances to angry classmates than to happy classmates. In contrast, conduct disorder patients’ interpersonal distance, did not differ between emotions. Interpersonal distance preferences were also associated with social anxiety and callous-unemotional traits.

Conclusion
The findings suggest that conduct disorder patients fail to adjust their interpersonal behaviour to the facial expression of social interaction partners and that this is associated with social anxiety and callous-unemotional traits. A lack of adjustment to social cues might contribute to and maintain problems with peers in individuals with conduct disorder.
Psychometric properties of the American version of the Chronic Uncertainty scale: long and short version (CU-40; CU-20)
Authors: Ghassabei Shiwa , Afifi Walid A. , Afifi Tamara , Petrowski Katja 
Published: November 2024

Abstract
Background
Uncertainty is a widespread phenomenon experienced worldwide. The bulk of existing research to date has focused on transitory or acute experiences of uncertainty, often in the particular context of illness. The current study evaluated the psychometric properties of the cross-contextual 40-item (long) and 20-item (short) Chronic Uncertainty scale (CU-40; CU-20).

Methods
A U.S. sample of 1083 participants (55% female) was recruited via Mechanical Turk (MTurk). Exploratory factor analysis revealed a six-factor model.

Results
Results of the Confirmatory factor analysis showed good model fit for the original and a slightly better model fit for the modified version of the CU-40 and CU-20. Slightly different item-to-factor attributions were suggested for the questionnaires. Internal consistencies were good for both models.

Conclusion
The evidence suggests that the CU scale offers psychometrically sound assessments of chronic uncertainty across a range of dimensions. Further assessments and implementations of the CU in different contexts using diverse samples are encouraged to test the efficacy of the CU measures as screening tools of general aspects of chronic uncertainty.
Manganese oxide nanomaterials: bridging synthesis and therapeutic innovations for cancer treatment
Authors: Balwe Sandip Gangadhar , Moon Dohyeon , Hong Minki , Song Joon Myong 
Published: November 2024

AbstractThe advent of precision medicine in oncology emphasizes the urgent need for innovative therapeutic strategies that effectively integrate diagnosis and treatment while minimizing invasiveness. Manganese oxide nanomaterials (MONs) have emerged as a promising class of nanocarriers in biomedicine, particularly for targeted drug delivery and the therapeutic management of tumors. These nanomaterials are characterized by exceptional responsiveness to the tumor microenvironment (TME), high catalytic efficiency, favorable biodegradability, and advanced capabilities in magnetic resonance imaging. These attributes significantly enhance drug delivery, facilitate real-time bioimaging, and enable early tumor detection, thereby improving the precision and effectiveness of cancer therapies. This review highlights the significant advancements in the synthesis and therapeutic applications of MONs, beginning with a comprehensive overview of key synthetic methods, including thermal decomposition, potassium permanganate reduction, exfoliation, adsorption–oxidation, and hydro/solvothermal techniques. We delve into the preparation of MONs and H–MnO₂-based nanomaterials, emphasizing their chemical properties, surface modifications, and toxicity profiles, which are critical for their clinical application. Moreover, we discuss the notable applications of H–MnO₂-based nanomaterials in pH-responsive drug release, overcoming multidrug resistance (MDR), immunotherapy, and the development of nanovaccines for synergistic cancer treatments. By addressing the current challenges in the clinical translation of MONs, we propose future research directions for overcoming these obstacles. By underscoring the potential of MONs to transform cancer treatment paradigms, this review aims to inspire further investigations into their multifunctional applications in oncology, thus ultimately contributing to more effective and personalized therapeutic strategies.
Graphical abstract
Erianin inhibits the progression of DDP-resistant lung adenocarcinoma by regulating the Wnt/β-catenin pathway and activating the caspase-3 for apoptosis in vitro and in vivo
Authors: Tang Lingxue , Ruan Yiling , Wang Beibei , Zhang Mingjun , Xue Jie , Wang Tong 
Published: November 2024

Abstract
Background
Platinum-based chemotherapy is one of the main treatments for lung adenocarcinoma (LUAD). However, the toxic side effects and drug resistance of chemotherapeutic drugs on normal cells are still a thorny problem in clinical treatment. Dendrobium is one of the three largest genera of Orchidaceous family, which has ornamental and medicinal value. Dendrobium is mainly distributed in the tropics and subtropics of South Asia, Oceania and other regions, with 1547 species of Dendrobium currently known. In China, “Shi hu” and “Tie pi shi hu” are well-known traditional medicines and have been included in the Chinese Pharmacopoeia (Editorial Board of Chinese Pharmacopoeia, 2020). Erianin is a natural product isolated from Dendrobium and is considered as a potential anticancer molecule due to its remarkable anti-tumor effects through various mechanisms, among which induced cancer cell apoptosis, inhibited invasion and migration. This study preliminarily explored the mechanism of Erianin inhibiting the progression of cisplatin (DDP) resistant LUAD in vivo and in vitro.

Methods
The effect of Erianin on the proliferation of DDP-resistant LUAD cells was detected by CCK-8 assay, wound healing assay and cloning assay. Transwell assay was used to evaluate the effect of Erianin on cell invasion and migration. The changes of cell cycle and apoptosis were detected by flow cytometry and TUNEL assay. Finally, the effects of Erianin on cell function and signaling pathway-related protein expression in vivo and in vitro were examined based on the enrichment analysis.

Results
Erianin could inhibit the proliferation, invasion and migration, induce apoptosis, altered cell cycle of DDP-resistant LUAD cells, and reverse the resistance to DDP. Western blotting results showed that Erianin exerted its anti-tumor effects by regulating the Wnt/β-catenin cascade in DDP-resistant LUAD cells.

Conclusion
Erianin may exerted its anti-tumor effect in DDP-resistant LUAD cells by regulating the Wnt3/β-Catenin/Survivin/Bcl-2/Caspase-3/Cyclin D1 axis.
A linear model to estimate modal split in international freight transport, based on revealed preferences about cost and time saving
Authors: Hoffmeister Onno , Dalheimer Bernhard 
Published: November 2024

AbstractWe present a new model for estimating the distribution of international freight transport over transport modes that is directly applicable to aggregated data, allows estimations and predictions also when some modes are infeasible on some routes, and requires few processing time and memory space. It builds on the assumption that demand for transport by a given mode is driven by trading firms’ and consumers’ preferences about saving transport costs and time. In contrast to conventional mode-choice models, it is linear and grounded on consumer demand theory. Applying the model to international freight transport as recorded in the latest upgrade of UN Comtrade reveals an average cost elasticity of transport demand of − 0.32 and an average time elasticity of − 0.18. In addition, we find significant independent mode-specific effects. Cost and time elasticities are highly dependent on the type of commodity transported. The cost elasticity ranges from zero to − 1.9 and the time elasticity from zero to − 3.3 across commodity groups defined at the four-digit level of the Harmonized System classification. These findings suggest that policy measures, exogenous shocks or other events that change the relative transport costs and transit times across modes can cause modal shifts—for some commodities more than for others—thereby mitigating the loss in welfare.
Lead-it-EAZY! GMP-compliant production of [212Pb]Pb-PSC-PEG2-TOC
Authors: Pretze Marc , Michler Enrico , Kästner David , Kunkel Falk , Sagastume Edwin A. , Schultz Michael K. , Kotzerke Jörg 
Published: November 2024

Abstract
Background
Recently, radiotheranostics comprising the true matched radionuclide pair 203/212Pb could serve as real dosimetric planning utility using 203Pb-radiolabelled pharmaceuticals before therapy with 212Pb-radiolabelled counterparts. 212Pb might act as the missing radionuclide therapy between standard β– therapies (e.g. with 177Lu or 90Y), in some cases leading to β– resistance and highly cytotoxic α therapies (e.g. with 225Ac) leading in some cases to renal insufficiency or even renal failure, due to the daughter nuclide 213Bi, which accumulates in > 90% within the kidneys during 225Ac therapy. 212Pb converts to 212Bi by β–-decay and the following pathway of decay bears in sum only one α decay, which certainly happens within the targeted tumour tissue. Following daughter nuclides (e.g. 208Tl), which could distribute in organs at risk have only β− or γ decay, which is not as cytotoxic as α decay.

Results
By ingenious customization of the standard cassettes of the ML EAZY it was possible to adapt the manual radiosynthesis of [212Pb]Pb-PSC-PEG2-TOC ([212Pb]Pb-VMT-α-NET) to a GMP-compliant synthesis module. The whole process of production, namely conditioning of C18 cartridge for purification, elution of the 224Ra/212Pb-generator, radiolabelling, C18 purification and sterile filtration performed automatically within one hour to access [212Pb]Pb-VMT-α-NET for patient application. [212Pb]Pb-VMT-α-NET was radiolabelled with high radiochemical purity > 95% and high radiochemical yield > 95% with molar activity ~ 15.8 MBq/nmol.

Conclusions
The Lead-it-EAZY process performed stable and robust over ten radiosyntheses and yielded sterile [212Pb]Pb-VMT-α-NET in high purity for patient application. By changing the precursor this process could easily be adapted to other 212Pb-radiopharmaceuticals.
Influence of the orientation of constructed blood vessels during the 3D printing on the measurement of the pseudo-oxygen saturation of an artificial blood substitute using conventional oxygen sensors: a test series
Authors: Jung Svenja , Hoffmann Martin , Winkler Dirk , Güresir Erdem , Kropla Fabian , Scholz Sebastian , Grunert Ronny 
Published: November 2024

Abstract
Background
The development of phantoms to reduce animal testing or to validate new instruments or operation techniques is of increasing importance. For this reason, a blood circulation phantom was developed to test a newly designed retractor system with an integrated oxygen sensor. This phantom was used to evaluate the impact of the 3D printed blood vessel on the measurement of the oxygen saturation.

Methods
A solution of nickel sulfate and copper sulfate was prepared as a substitute for real blood. The absorption spectra of these solutions were recorded and compared with those of blood. Subsequently, the oxygen sensor used was calibrated to the blood substitute. Additionally, blood vessels with a simplified geometry were designed and manufactured using inverted vat polymerization and an elastic material (Formlabs Elastic 50 A). To determine the orientation during the printing process, various vessels were printed. Measurements to assess the effects of disturbance (rotation of the vessels during measurements) on the sensor readouts were prepared.

Results
The impact of disturbances was verified through the rotation of the 3D printed vessels. It was demonstrated that a direct measurement on the disturbances led to outliers and higher values. An optimal orientation was determined to be a lateral placement (90° or 270°) of the sensor. Regarding the orientation of the vessels within the printing space, an orientation of 45° yielded the best results, as the individual layers had the least impact on the light emitted and received by the oxygen sensor.

Conclusion
The achieved results demonstrate the influence of the orientation of the vessel during 3D printing as well as the influence of the position of the vessel during the measurement using a conventional oxygen sensor.