bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bayesian Approach for Extracting Fluorescence Lifetimes from Sparse Data Sets and Its Significance for Imaging Experiments
Authors: Santra Kalyan , Smith Emily A. , Song Xueyu , Petrich Jacob W. 
Published: November 2018

AbstractThe measurement of fluorescence lifetimes, especially in small sample volumes, presents the dual challenge of probing a small number of fluorophores and fitting the concomitant sparse data set to the appropriate excited‐state decay function. A common method of analysis, such as the maximum likelihood (ML) technique, assumes a uniform probability distribution of the parameters describing the fluorescence decay function. An improvement is thus suggested by implementing a suitable nonuniform distribution, as is provided by a Bayesian framework, where the distribution of parameters is obtained from both their prior knowledge and the evidence‐based likelihood of an event for a given set of parameters. We have also considered the Dirichlet prior distribution, whose mathematical form enables analytical solutions of the fitting parameters to be rapidly obtained. If Gaussian and exponential prior distributions are judiciously chosen, they reproduce the experimental target lifetime to within 20% with as few as 20 total photon counts for the data set, as does the Dirichlet prior distribution. But because of the analytical solutions afforded by the Dirichlet prior distribution, it is proposed to employ a Dirichlet prior to search parameter space rapidly to provide, if necessary, appropriate parameters for subsequent employment of a Gaussian or exponential prior distribution.
Genome‐wide association studies on the phyllosphere microbiome: Embracing complexity in host–microbe interactions
Authors: Beilsmith Kathleen , Thoen Manus P.M. , Brachi Benjamin , Gloss Andrew D. , Khan Mohammad H. , Bergelson Joy 
Published: November 2018

SummaryEnvironmental sequencing shows that plants harbor complex communities of microbes that vary across environments. However, many approaches for mapping plant genetic variation to microbe‐related traits were developed in the relatively simple context of binary host–microbe interactions under controlled conditions. Recent advances in sequencing and statistics make genome‐wide association studies (GWAS) an increasingly promising approach for identifying the plant genetic variation associated with microbes in a community context. This review discusses early efforts on GWAS of the plant phyllosphere microbiome and the outlook for future studies based on human microbiome GWAS. A workflow for GWAS of the phyllosphere microbiome is then presented, with particular attention to how perspectives on the mechanisms, evolution and environmental dependence of plant–microbe interactions will influence the choice of traits to be mapped.
Zircon U–Pb ages and Lu–Hf isotopes of metagranitoids from the Subansiri region, Eastern Himalaya: implications for crustal evolution along the northern Indian passive margin in the early Paleozoic
Authors: Bikramaditya R. K. , Singh A. Krishnakanta , Chung Sun-Lin , Sharma Rajesh , Lee Hao-Yang 
Published: November 2018

Abstract

We studied the zircon U–Pb ages, Hf isotopes, and whole-rock and mineral chemistry of metagranitoids from the Subansiri region of the Eastern Himalaya to constrain their emplacement age, origin and geodynamic evolution. The investigated metagranitoids have high SiO
2
, Na
2
O + K
2
O, Rb, Zr and low Fe
2
O
3
, Nb, Ga/Al ratios with fractionated rare earth element patterns [(Ce/Yb)
N
= 6.46–42.15] and strong negative Eu anomalies (Eu/Eu* = 0.16–0.44). They are peraluminous (molar A/CNK = 1.04–1.27) and calc-alkaline in nature, with normative corundum (1.04–3.61) and relatively high FeO
t
/MgO ratios in biotite (
c.
3.38), indicating their affinity with S-type granites. The time of emplacement of the Subansiri metagranitoids is constrained by zircon U–Pb ages between 516 and 486 Ma. The zircon grains have negative ε
Hf
(
t
) values ranging from −1.4 to −12.7 and yield crustal Hf model ages from 1.5 to 2.2 Ga, suggesting the occurrence of a major crustal growth event in the Proterozoic and re-melting of the crust during the early Paleozoic. The geochemical data in conjunction with the U–Pb ages and Hf isotope data suggest that the Subansiri metagranitoids were produced by partial melting of older metasedimentary rocks in the Indian passive margin.

Supplementary material:
Hf isotope results for the Mud Tank zircon standard acquired during the experimental period are available at
https://doi.org/10.6084/m9.figshare.c.4299830
Structural setting and detrital zircon U–Pb geochronology of Triassic–Cenozoic strata in the eastern Central Pamir, Tajikistan
Authors: He John , Kapp Paul , Chapman James B. , DeCelles Peter G. , Carrapa Barbara 
Published: November 2018

Abstract

Integration of new geological mapping, detrital zircon geochronology, and sedimentary and metamorphic petrography south of the Muskol metamorphic dome in the Central Pamir terrane provides new constraints on the evolution of the Pamir orogen from Triassic to Late Oligocene time. Zircon U–Pb data show that the eastern Central Pamir includes Triassic strata and mélange that are of Karakul–Mazar/Songpan–Ganzi affinity and comprise the hanging wall of a thrust sheet that may root into the Tanymas Fault
c.
35 km to the north. The Triassic rocks are unconformably overlain by Cretaceous strata that bear similarities to coeval units in the southern Qiangtang terrane and the Bangong Suture Zone of central Tibet. Finally, Oligocene or younger conglomerate and interbedded siltstone, the youngest documented strata in the Pamir Plateau proper, record an episode of juvenile magmatism at
c.
32 Ma, which is absent in the extant rock record and other detrital compilations from the Pamir but overlaps in age with ultrapotassic volcanic rocks in central Tibet. Zircon Hf isotopic data from the Oligocene grains (
ε
Hf
(t) ≈ +9.6) suggest a primary mantle contribution, consistent with the hypothesis of Late Eocene lithospheric removal beneath the Pamir Plateau.
Sleep in Caregivers of Children With Type 1 Diabetes
Authors: Feeley Christine A. , Clougherty Marilyn , Siminerio Linda , Charron-Prochownik Denise , Allende Anna L. , Chasens Eileen R. 
Published: November 2018

Purpose The purpose of this study was to explore caregivers’ descriptions of their experience of nighttime sleep. Design and Methods Caregivers (N = 22) of children 10 to 18 years of age with type 1 diabetes (T1D) were recruited for this descriptive study. Anonymous questionnaires contained demographic information and both open- and closed-ended questions that focused on caregiving as it related to sleep. Open-ended questions were reviewed to help understand the effect of nocturnal caregiving activities on parental sleep. Results The sample of caregivers were all female and had a mean age of 43 years; 96% graduated high school, 68% were married or partnered, and 100% were white. Children had been diagnosed with T1D for a mean of 5 years, with a mean age of 12.2 years. Caregivers reported short sleep duration (mean, 5.8 hours). Over half of the participants reported they required ≥7 hours of sleep to feel their best, 64% indicated trouble sleeping at night, and 86% reported that caregiving interfered with their nighttime sleep, while 54% responded that sleep was “very important.” Content analysis of the open-ended questions revealed 2 themes: (1) anxiety about the child’s blood glucose levels and (2) nighttime disruptions. Conclusions Caregivers are frequently sleep deprived and worry about their child’s nighttime glucose. Caregiving duties, anxiety, and sleep fragmentation may contribute to their poor sleep.
Biochemical changes associated with temporomandibular disorders
Authors: Demir Canser Yilmaz , Ersoz Muhammet Eren 
Published: November 2018

Objective To assess vitamin D, parathyroid hormone, calcitonin, calcium, phosphorus and magnesium levels in patients with versus without temporomandibular disorders (TMDs). Methods This prospective observational study included patients with TMDs and age-matched healthy controls. TMDs were diagnosed via physical and radiologic examination, and serum levels of 25 (OH) vitamin D, parathyroid hormone, calcitonin, calcium, magnesium, and phosphorus were determined. The impact of age, sex and seasonal variations in serum 25 (OH) vitamin D levels was controlled by the inclusion of age, sex and date-matched control patients. Results The study included 100 patients, comprising 50 patients with TMDs and 50 control patients. No statistically significant between-group differences were found regarding age or sex. No statistically significant between-group differences were found in terms of serum 25 (OH) vitamin D, calcitonin, calcium, magnesium or phosphorus levels. Parathyroid hormone levels were statistically significantly higher in patients with TMDs versus healthy control patients. Conclusion In patients with temporomandibular disorders, increased parathyroid hormone levels in response to vitamin D deficiency was significantly more prominent. These data suggest that, in patients with temporomandibular disorders, vitamin D deficiency should be assessed and corrected.
Drafting for Success: How Good Are NFL Teams at Identifying Future Productivity at Offensive-Skill Positions in the Draft?
Authors: Pitts Joshua D. , Evans Brent 
Published: November 2018

Employing data on offensive-skill players drafted between 2002 and 2013, we are able to determine if the factors correlated with a player’s productivity in the National Football League (NFL) are the same factors correlated with him being selected earlier in the NFL draft. While our findings affirm many of the strategies employed by NFL teams, the analysis uncovers potential avenues for improving drafting strategy. For instance, our results suggest that teams are overvaluing or undervaluing certain player characteristics on draft day. We also compare the performance of our empirical models with that of NFL teams in their ability to project the future productivity of incoming players. We conclude that the NFL teams most likely to enjoy success moving forward are those that are able to combine traditional player evaluation methods with analytical approaches to player evaluation. JEL Classifications: L83, M51, Z20, Z22
Changes in Food Insecurity and Smoking Status over Time: Analysis of the 2003 and 2015 Panel Study of Income Dynamics
Authors: Kim-Mozeleski Jin E. , Seligman Hilary K. , Yen Irene H. , Shaw Susan J. , Buchanan David R. , Tsoh Janice Y. 
Published: November 2018

Purpose: To examine whether food insecurity longitudinally affects smoking status. Design: Population-based prospective study Setting: Data from the 2003 and 2015 Panel Study of Income Dynamics (PSID). Participants: Four thousand five hundred sixty-three adults who were smokers and nonsmokers, participating in the 2003 (current study baseline) and 2015 (current study follow-up) waves of PSID. Measures: Based on self-reported smoking status at baseline and follow-up, respondents were categorized as continued smoking, stopped smoking, started smoking, and continued nonsmoking. Similarly, respondents were categorized as stayed food secure, stayed food insecure, became food insecure, and became food secure based on responses to the Food Security Survey at baseline and follow-up. Analysis: Two logistic regression analyses to examine (1) among smokers at baseline the odds of stopping versus continuing smoking by follow-up and (2) among nonsmokers at baseline the odds of starting versus continuing nonsmoking by follow-up. In both models, change in food insecurity status was the primary independent variable, controlling for demographics including poverty. Results: Among smokers at baseline, becoming food insecure (vs staying food secure) was independently associated with lower likelihood of stopping smoking by follow-up (odds ratio [OR] = 0.66). Among nonsmokers at baseline, becoming food insecure (vs staying food secure) was independently associated with higher likelihood of starting smoking by follow-up (OR = 3.77). Conclusions: Food insecurity is a risk factor for smoking, which has significant implications for developing interventions to reduce smoking prevalence, especially among low-income groups.
Do Health-Care Professionals Really Understand the Role of Occupational Therapy in Hospice Care?
Authors: Knecht-Sabres Lisa Jean , Weppner Ashley , Powers Cassandra , Siesel Brooke 
Published: November 2018

Background: The distinct value of occupational therapy (OT) in end-of-life care is to facilitate quality of life for clients and their caregivers through engagement in occupations during the clients’ remaining days. The purpose of this study was to explore health-care professionals’ perceptions and knowledge regarding the role of OT in hospice care and to better understand why OT may be underutilized in this setting. Participants: A total of 104 professionals working in hospice care from 31 different states participated in this study. Methods: Electronic surveys were distributed to hospice agencies throughout the United States. Data Analysis: Descriptive statistics was used to analyze quantitative data, and content analysis was used to identify patterns with qualitative data. Rigor was enhanced through peer-review, multiple coders, and triangulation. Results: The results of this study revealed that OT’s role in hospice care is misunderstood, and OT services are underutilized. Five themes were identified regarding the underutilization of OT services: (1) lack of reimbursement, (2) timing of referral, (3) knowledge of the role of OT, (4) refusal of services by family members, and (5) lack of OT presence in this setting. Conclusion: This study revealed that health-care professionals do believe that OTs are vital members of the hospice care team. However, many recipients of hospice care are not receiving OT. More consistent referrals to OT may better ensure that the terminally ill are able to attain end-of-life goals and live their lives to the fullest, regardless of life expectancy.
Inter-rater and inter-device reliability of mechanical thresholds measurement with the Electronic von Frey Anaesthesiometer and the SMALGO in healthy cats
Authors: Adami Chiara , Lardone Elena , Monticelli Paolo 
Published: November 2018

Objectives The aim of this study was to compare the Electronic von Frey Anaesthesiometer (EVF) and the Small Animal ALGOmeter (SMALGO), used to measure sensory thresholds in 13 healthy cats at both the stifle and the lumbosacral joint, in terms of inter-rater and inter-device reliability. Methods Two independent observers carried out the sets of measurements in a randomised order, with a 45 min interval between them, in each cat. The inter-rater and inter-device reliability were evaluated by calculating the inter-rater correlation coefficient (ICC) for each pair of measurements. The Bland–Altman method was used as an additional tool to assess the level of agreement between the two algometers. Results The mean ± SD sensory thresholds measured with the EVF were 311 ± 116 g and 378 ± 178 g for the stifle and for the lumbosacral junction, respectively, whereas those measured with the SMALGO were 391 ±172 g and 476 ± 172 g. The inter-rater reliability was fair (ICC >0.4) for each pair of measurements except those taken at the level of the stifle with the SMALGO, for which the level of agreement between observers A and B was poor (ICC = 0.01). The inter-device reliability was good (ICC = 0.73; P = 0.001). The repetition of the measurements affected reliability, as the thresholds obtained after the 45 min break were consistently lower than those measured during the first part of the trial ( P = 0.02). Conclusions and relevance The EVF and the SMALGO may be used interchangeably in cats, especially when the area to be tested is the lumbosacral joint. However, when the thresholds are measured at the stifle, the inter-observer reliability is better with the EVF than with the SMALGO. The reliability decreases when the measurements are repeated within a short time interval, suggesting a limited clinical applicability of quantitative sensory testing with both algometers in cats.
Vaccination Guidelines for Patients With Immune-Mediated Disorders on Immunosuppressive Therapies
Authors: Papp Kim A. , Haraoui Boulos , Kumar Deepali , Marshall John K. , Bissonnette Robert , Bitton Alain , Bressler Brian , Gooderham Melinda , Ho Vincent , Jamal Shahin , Pope Janet E. , Steinhart A. Hillary , Vinh Donald C. , Wade John 
Published: November 2018

Background: Patients with immune-mediated diseases on immunosuppressive therapies have more infectious episodes than healthy individuals, yet vaccination practices by physicians for this patient population remain suboptimal. Objectives: To evaluate the safety and efficacy of vaccines in individuals exposed to immunosuppressive therapies and provide evidence-based clinical practice recommendations. Methods: A literature search for vaccination safety and efficacy in patients on immunosuppressive therapies (2009-2017) was conducted. Results were assessed using the Grading of Recommendation, Assessment, Development, and Evaluation system. Results: Several immunosuppressive therapies attenuate vaccine response. Thus, vaccines should be administered before treatment whenever feasible. Inactivated vaccines can be administered without treatment discontinuation. Similarly, evidence suggests that the live zoster vaccine is safe and effective while on select immunosuppressive therapy, although use of the subunit vaccine is preferred. Caution regarding other live vaccines is warranted. Drug pharmacokinetics, duration of vaccine-induced viremia, and immune response kinetics should be considered to determine appropriate timing of vaccination and treatment (re)initiation. Infants exposed to immunosuppressive therapies through breastmilk can usually be immunized according to local guidelines. Intrauterine exposure to immunosuppressive agents is not a contraindication for inactivated vaccines. Live attenuated vaccines scheduled for infants and children ⩾12 months of age, including measles, mumps, rubella, and varicella, can be safely administered as sufficient time has elapsed for drug clearance. Conclusions: Immunosuppressive agents may attenuate vaccine responses, but protective benefit is generally maintained. While these recommendations are evidence based, they do not replace clinical judgment, and decisions regarding vaccination must carefully assess the risks, benefits, and circumstances of individual patients.
The ballad of Leah and Amanda: Ritual and history at the wedding of a Jewish lesbian couple in Melbourne, Australia
Authors: Silverstein Jordana 
Published: November 2018

At the beginning of 2014, Leah and Amanda became one of the first pairs of Jewish lesbians to have a Jewish wedding in Melbourne, Australia. Held in a secular reception venue and officiated by a Reform rabbi, this ceremony was a Jewish religious ceremony that had no relationship to the Australian state. In this ceremonial search for a ritual that would be true to themselves, would express their love, and would engage with communal and familial cultures and histories, dominant discourses of both Jewish and Australian weddings were simultaneously challenged and reinforced. In this article, utilizing oral history methodologies, I will explore some of the ways that Leah and Amanda articulated and enacted their relationships, histories and futures. In particular, I suggest that their utterances make visible the production of historically specific iterations of normativity. Through an exploration of this intimate relationship, this article thus works to come to an understanding of some of the ways in which Australian Jewish lesbian practices and ideas of assimilation, normativity and difference, come to exist. How can these relationships be both normative and transgressive, as lesbian relationships and as Jewish ones? By inquiring into the Jewish character, as well as the lesbian character, of this wedding and this intimate relationship between these two women, this article proposes an intervention into historical understandings of homonormativity.
Phone-based intervention for blood pressure control among Ghanaian stroke survivors: A pilot randomized controlled trial
Authors: Sarfo Fred Stephen , Treiber Frank , Gebregziabher Mulugeta , Adamu Sheila , Nichols Michelle , Singh Arti , Obese Vida , Sarfo-Kantanka Osei , Sakyi Asumadu , Adu-Darko Nyantakyi , Tagge Raelle , Agyei-Frimpong Marian , Kwarteng Naomi , Badu Elizabeth , Mensah Nathaniel , Ampofo Michael , Jenkins Carolyn , Ovbiagele Bruce ,   on behalf of PINGS Team
Published: November 2018

Background The potential of mobile-health (mHealth) technology for the management of hypertension among stroke survivors in Africa remains unexplored. We assessed whether an mHealth technology-enabled, nurse-guided intervention initiated among stroke patients within one month of symptom onset is effective in improving their blood pressure (BP) control. Methods A two-arm pilot cluster randomized controlled trial involving 60 stroke survivors, ≥18 years, with BP ≥140/90 mmHg at screening/enrollment visit at a medical center in Ghana. Participants in the intervention arm (n = 30) received a Blue-toothed BP device and smartphone with an App for monitoring BP measurements and medication intake under nurse guidance for three months after which intervention was withdrawn. Control arm (n = 30) received usual care. Primary outcome measure was proportion with clinic BP < 140/90 mmHg at month 9; secondary outcomes included medication adherence. Findings Mean ± SD age was 55 ± 13 years, 65% males. Two participants on intervention and three in control group were lost to follow-up. At month 9, proportion on the intervention versus controls with BP < 140/90 mmHg was 14/30 (46.7%) versus 12/30 (40.0%), p = 0.79 by intention-to-treat; systolic BP < 140 mmHg was 22/30 (73.3%) versus 13/30 (43.3%), p = 0.035. Mean ± SD medication possession ratio was 0.95 ± 0.16 on intervention versus 0.98 ± 0.24 in the control arm, p = 0.56. Interpretation We demonstrate feasibility and signal of improvement in BP control among stroke survivors in a resource-limited setting via an mHealth intervention. Larger scale studies are warranted. Trial registration NCT02568137. Registered on 13 July 2015 at ClinicalTrials.gov.