bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing a Scientifically Valid, Cost-Effective, and Scalable Data Collection System at Point of Care
Authors:   OME Cleveland Clinic Orthopaedics1
Published: March 2019

Background:
Improving outcomes after surgical procedures and determining the value of health care can be facilitated by a scientifically valid, cost-effective, and scalable data outcome collection system. We hypothesized that such a system could be constructed in orthopaedic surgery to (1) capture >95% of baseline validated patient-reported outcome measures (PROMs) for patients undergoing elective surgery, (2) capture >95% of surgeon-entered data on disease severity and treatment, and (3) be implemented as standard clinical care in daily practice.

Methods:
A modified Research Electronic Data Capture (REDCap) system was developed and was implemented at the time of surgery in a prospective cohort to collect demographic data, general health PROMs, joint-specific PROMs, and disease severity and treatments from patients and surgeons. All elective knee, hip, and shoulder orthopaedic surgical procedures performed in the Cleveland Clinic system at 7 hospitals were included.

Results:
Of 16,021 consecutive eligible patients (February 18, 2015, to July 31, 2017), 2% (320) were excluded because of language or physical barriers, and 0.6% (91) of the remaining 15,701 patients refused to participate. Of the remaining 15,610 patients, 97.4% (15,202) completed PROMs, and surgeons provided details on the disease severity and treatment for 99.9% (15,592) of the 15,610 patients. Overall, 97.3% (15,185) of the 15,610 patients had complete patient-reported and surgeon-reported baseline enrollment. The median completion time was 11.5 minutes for the patients and 1.6 minutes for the surgeons. The overall complete 1-year follow-up rate was 72.5% (9,354 of 12,896).

Conclusions:
A data collection system with validated measures with >97% baseline completion of PROMs and surgeon forms regarding disease severity and treatments, across elective knee, hip, and shoulder orthopaedic surgical procedures, was successfully implemented at 7 hospitals. The system is potentially scalable to the entire orthopaedic community and could serve as a template for all procedural-based specialties during routine patient care.
Biosorption of crystal violet dye using inactive biomass of the fungus Diaporthe schini
Authors: Grassi Patrícia , Reis Caroline , Drumm Fernanda C. , Georgin Jordana , Tonato Denise , Escudero Leticia B. , Kuhn Raquel , Jahn Sérgio L. , Dotto Guilherme L. 
Published: March 2019

Abstract
An inactive biomass of a new fungus recently discovered, Diaporthe schini, was evaluated for the biosorption of crystal violet (CV) in simulated textile effluents. The characterization assays were performed using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and N2 adsorption/desorption isotherms. The influences of pH and biosorbent dosage on the biosorption capacity were evaluated. Kinetics, equilibrium and thermodynamic studies were also carried out. Characterization techniques showed an amorphous biosorbent, with a rough surface containing irregular particles and surface area of 6.5 m2 g−1. The most adequate values of pH and biosorbent dosage were 7.5 and 0.4 g L−1, respectively. The Elovich kinetic model and the Sips equilibrium model were suitable to fit the experimental data. The biosorption capacity increased with temperature, reaching a maximum biosorption capacity of 642.3 mg g−1 at 328 K. The biosorption was a spontaneous and endothermic process. Diaporthe schini inactive biomass was an interesting biosorbent to treat colored effluents, presenting efficiency of 87% in the decolorization of a simulated dye house effluent.
Comparison of the Full-Length and 152~528 Truncate of Human Cyclic Nucleotide Phosphodiesterase 4B2 for the Characterization of Inhibitors
Authors: Zhang Xiang , He Shu , Hu Xiaolei , Wu Jing , Li Xinpeng , Liao Fei , Yang Xiaolan 
Published: March 2019

Aim and Objective:
Human full-length cyclic nucleotide phosphodiesterase isozyme
4B2 (hPDE4B2) as the target for screening and characterizing inhibitors suffers from low activity
yield and the coexistence of two conformational states bearing different affinities for (R)-rolipram.
Hence, the 152~528 truncate of hPDE4B2 existing only in the low-affinity conformation state for
(R)-rolipram was compared against the full-length hPDE4B2 to characterize inhibitors.

Materials and Methods:
With 6His-SUMO tag at the N-terminus, both the full-length hPDE 4B2
(SF-hPDE4B2) and the 152~528 truncate (ST-hPDE4B2) were expressed in Escherichia coli cells,
purified through Ni-NTA column and compared for the characterization of inhibitors. The
inhibition constants (Ki) of some synthesized rolipram analogues against both targets were
determined with 96-well microplate through the coupled action of monophosphatase on AMP and
spectrophotometric assay of phosphate with malachite green.

Results:
After affinity purification with Ni2+-NTA column, ST-hPDE4B2 showed about 30-fold
higher specific activity and 100-fold higher activity yield than SF-hPDE4B2; Ki of (R)-rolipram on
ST-hPDE4B2 was consistent with that on the low-affinity state of the untagged full-length
hPDE4B2 expressed in insect cells. Of some representative rolipram analogues as inhibitors, a
dual-logarithm model quantitatively described their monotonic association, and Ki from 0.010 mM
to 8.5 mM against SF-hPDE4B2 was predicted from Ki against ST-hPDE4B2, supporting the
discovery of consistent hits by the use of both targets with a pair of properly-set cutoffs.

Conclusion:
ST-hPDE4B2 with much higher activity yield may be a favorable alternative target to
characterize/screen rolipram analogues as hPDE4B inhibitors in high-throughput mode.
Induction of a Robust Humoral Response using HIV-1 VLPMPER-V3as a Novel Candidate Vaccine in BALB/c Mice
Authors: Tohidi Fatemeh , Sadat Seyed Mehdi , Bolhassani Azam , Yaghobi Ramin , Larijani Mona Sadat 
Published: March 2019

Background:Several approaches have not been successful to suppress HIV (Human immunodeficiency virus) infection among infected individuals or to prevent it yet. In order to expand strong HIV specific humoral and cellular responses, Virus-like particles (VLPs) as potential vaccines show significant increase in neutralizing antibodies secretion, T-cell count and also secretion of cytokines.Objective:This study aimed at immunological evaluation of VLPs harboring high copy of MPERV3 in BALB/c mice.Methods:Female BALB/c mice were immunized with homologous and heterologous primeboosting regimens of HIV-1 VLPMPER-V3. Their immune responses were evaluated for humoral responses (Total IgG and IgG isotyping) and cellular responses (IFN-γ, IL-5 secretion, in vitro CTL assay and T cell proliferation) and compared in immunized mice.Results:The data showed robust induction of humoral response in mice groups which received different regimens of VLP. Furthermore, analysis of cytokine profile indicated that the highest IL-5 secretion was related to VLP+M50 group and confirmed the dominance of Th2 immunity in this group.Conclusion:This study showed that VLP MPER-V3 as a potential vaccine candidate has the potency as an effective prophylactic vaccine and this finding guarantees further investigations to achieve a promising HIV-1 vaccine candidate.
Prediction of CD4+ Cells Counts in HIV/AIDS Patients based on Sets and Probability Theories
Authors: Rodriguez Javier , Prieto Signed , Correa Catalina , Melo Martha , Dominguez Dario , Olarte Nancy , Suárez Daniela , Aragón Laura , Torres Fernando , Santacruz Fernando 
Published: March 2019

Background:Previous studies have developed methodologies for predicting the number of CD4+ cells from the total leukocyte and lymphocytes count based on mathematical methodologies, obtaining percentages of effectiveness prediction higher than 90% with a value of less than 5000 leukocytes.Objective:To improve the methodology probabilities prediction in 5000-9000 leukocytes ranges.Method:from sets A, B, C and D defined in a previous study, and based on CD4+ prediction established on the total number of leukocytes and lymphocytes, induction was performed using data from 10 patients with HIV, redefining the sets A and C that describe the lymphocytes behavior relative to leukocytes. Subsequently, we evaluated with previous research prediction probabilities parameters from a sample of 100 patients, calculating the belonging probability to each sample and organized in predetermined ranges leukocytes, of each of the sets defined, their unions and intersections. Then the same procedure was performed with the new sets and the probability values obtained with the refined method were compared with respect to previously defined, by measures of sensitivity (SENS) and Negative Predictive Value (NPV) for each range.Results:probabilities with values greater than 0.83 were found in five of the nine ranges inside the new sets. The probability for the set A∪C increased from 0.06 to 0.18 which means increases between 0.06 and 0.09 for the intersection (A∪C) ∩ (B∪D), making evident the prediction improvement with new sets defined.Conclusion:The results show that the new defined sets achieved a higher percentage of effectiveness to predict the CD4+ value cells, which represents a useful tool that can be proposed as a substitute for clinical values obtained by the flow cytometry.
Acculturation Process and Life Domains: Different Perceptions of Native and Immigrant Adults in Italy
Authors: Rania Nadia , Rebora Stefania , Migliorini Laura , Navas Maria Soledad 
Published: March 2019

Background:
Acculturation process has taken up a relevant place in cross-cultural psychology by demonstrating the strong relationships between cultural context and individual behavioral development.

Aim:
The purpose of this study is to analyse acculturation strategies and attitudes in different life domains of native and immigrant adults living in Italy, following the Relative Acculturation Extended Model (RAEM).

Methods:
The participants were 250 Italian native and 100 immigrant adults who completed a questionnaire with items to measure their acculturation strategies (real plane) and attitudes (ideal plane), in general and related to different life domains (peripheral and central).

Results:
Results revealed that the acculturation attitude of immigrants is integration, whereas Italians prefer their assimilation.

Conclusion:
However, when different life domains are taken into account, immigrants claim to put in practice and prefer integration in most of the domains, whereas Italians perceive immigrants are separated but they prefer their assimilation or integration, depending on the specific domain.
Effects and control of metal nutrients and species on Microcystis aeruginosa growth and bloom
Authors: Zhou Haidong , Chen Xiaomeng , Liu Xiaojing , Xuan Yumei , Hu Tao 
Published: March 2019

AbstractThe effects and control of typical metal nutrients, copper, iron, and zinc, on the growth and bloom of Microcystis aeruginosa were investigated with a series of flask‐shaking tests. The optimal concentrations of copper, iron, and zinc for algal growth were 0.001, 3–12, and 0.05 mg/L, respectively. The order of toxicity to the alga was Cu > Zn > Fe. The effects of the species, for a trace metal at the same concentrations, on the growth of M. aeruginosa were relatively remarkable. Ionic and complexation species induced more algal growth than the carbonate and sulfide‐bound species. Changes in copper concentration and iron species were adopted to adjust and control the bloom of M. aeruginosa. Increases in copper concentrations significantly suppressed the M. aeruginosa bloom. The growth rate of M. aeruginosa slowed significantly when ionic iron was replaced with sulfide‐bound iron, and the control of bloom was remarkable.Practitioner points

Using trace metal nutrient species and concentration to regulate and control algal growth and bloom may pave another way for the management of cyanobacterial bloom.
Atitude, hábitos de estudo e rendimento académico: Abordagem desde a teoria da ação racional
Authors: Andrade-Valles I. , Facio-Arciniega S. , Quiroz –Guerra A. , Alemán-de la Torre L. , Flores-Ramírez M. , Rosales-González M 
Published: March 2019

Introdução: As atitudes e os hábitos em direção ao estudo e à aprendizagem são um fator de suma importância na determinação do desempenho académico. Objetivo: Analisar a correlação entre atitude e hábitos de estudo com o desempenho académico em estudantes universitários.
Metodologia: É uma pesquisa de corte quantitativo, transversal, correlacional e analítico, participaram 286 estudantes de maneira voluntária. Para medir as variáveis utilizaram-se o Inventario de hábitos de estudo e o Questionário de Avaliação de Atitudes ante a Aprendizagem em Estudantes Universitários. Os dados analisaram-se mediante o programa estatístico STATA v.11.1, realizaram-se provas de comparação de frequências (chi-quadrado), de correlação (r de Pearson) e análise de regressão logística.
Resultados: Do total dos participantes (n=286), 75.8% foram do sexo feminino; 43.7% (n=125) tiveram alto rendimento académico, com média geral de 9 ou mais. A respeito dos hábitos de estudo, 66.4% (n=190) obtiveram pontuações na classificação de adequados, 25.2% (n=72) apresentaram atitudes positivas para o estudo; obteve-se uma associação altamente significativa (p=0.001,) entre hábitos e atitudes ante o estudo mediante uma prova de chi-quadrado. A correlação entre hábitos de estudo e atitudes para o estudo foi moderada, mas significativa (r=0.461, p<0.05); a análise de regressão logística, revelou associações positivas entre atitudes e rendimento académico.
Conclusões: Este estudo demonstra que as atitudes e os hábitos de estudo, tem um forte impacto no desempenho académico.
Model of the Relationships between Supervising Working Alliance, Counseling Self-Esteem and Attachment Styles
Authors: Al- Shraifin Ahmad 
Published: March 2019

The study aimed to explore the causal relationships between supervising working alliance, counseling self-esteem and attachment styles through a causal model adopting a path analysis method. The study sample consisted of 289 counseling students at Yarmouk University. Three scales were administered to measure the supervising working alliance, self-esteem and attachment styles. Results showed a direct relationship between avoidant attachment styles and supervising working alliance, and an indirect relationship with counseling self-esteem. There was a direct relationship between secure attachment style, supervising working alliance and counseling self-esteem; and between supervising working alliance and counseling self-esteem. In addition, direct and indirect relationships were evident between avoidant attachment style and special relationship domain of supervising working alliance and counseling self-esteem; whereas it affected client focus domain with a direct relationship. Direct relationships also were evident between secure attachment styles, the relationship domain and self-focus domain.
Causal Relationship Modeling of the Big-Five Factors, Self-Efficacy, and Happiness of Jordan University of Science and Technology Students
Authors: Al-Dababi Khaldoun , Al- Dababi Rabe’a , Abdelrahman Abdulsalam 
Published: March 2019

The purpose of this study was to unveil the causal relationship of the big-five factors, self-efficacy and happiness for JUST students. Based on scientific foundations, it constructed a proposed causal relationship model using path analysis for interpreting happiness. To achieve this goal, the Big Five Factors by John, Donahue & Kentle, (1991), the General Self-Efficacy Scale of Schwarzer & Jerusalem, (1995), and Oxford Happiness Inventory were employed. The sample consisted of 377 students chosen on availability grounds. The results showed no statistically significant differences between the proposed and the optimal causal relationship models due to high matches on AGFI=0.942; NFI=0.986; RMSEA=0.069; GFI=0.994; IFI=0.991; TLI=0.933; and CFI=0.990. Thus, the model construes the relationships proposed and represents the optimal causal relationship model for the variables of the study.
Prevalência de infecções urinárias e do trato genital em gestantes atendidas em Unidades Básicas de Saúde
Authors: Santos Carla Cristian , Madeira Heloise Skiavine , Silva Claudinei Mesquita da , Teixeira Jorge Juarez Vieira , Peder Leyde Daiane de 
Published: March 2019

ObjetivoEsta pesquisa teve por objetivo determinar a prevalência de fatores associados às infecções do trato urinário e genital em mulheres em período gestacional.MétodosTrata-se de pesquisa epidemiológica de caráter descritivo com abordagem quantitativa, realizada por meio da coleta de dados em prontuários de gestantes atendidas em nove Unidades Básicas de Saúde distribuídas em Cascavel, Paraná, entre janeiro e dezembro de 2015. Foram consideradas as gestantes com diagnóstico positivo para qualquer doença que acometa os tratos genital e urinário. Foram coletadas dos prontuários informações sociodemográficas, comportamentais, clínicas e resultados laboratoriais. Para as análises estatísticas foi utilizado o método de Qui-Quadrado.ResultadosForam analisados 798 prontuários, observando-se uma positividade de 33,08% (264 casos) com infecções do trato urinário, genital ou ambos. Destas pacientes, 125 (15,66%) apresentaram episódios de infecções do trato urinário, 115 (14,41%) foram acometidas por algum tipo de infecção genital e 24 (3,01%) estavam coinfectadas. Verificou-se diferença estatística em relação ao número de pacientes que apresentaram sinais e sintomas característicos para infecções do trato urinário (<0,001), infecção genital (<0,001) e para casos anteriores de infecções do trato urinário (<0,001). A maioria das infecções do trato genital deu-se por Gardnerella vaginalis (43/37,39%) e Candida sp. 34/29,57%). ConclusãoOs resultados indicam altas prevalências de infecções do trato urinário e infecção genital, considerando que, em gestantes, as consequências para o bebê podem ser graves, o que torna o diagnóstico dessas doenças de suma importância na determinação de medidas preventivas. Sendo assim, a investigação, o diagnóstico precoce e o tratamento adequado auxiliam no controle de infecções e problemas congênitos.
Borsa İstanbul konaklama işletmelerinde finansal başarısızlık riskinin Beaver Modeli kullanılarak analizi
Authors: KARADENİZ Erdinç , ÖCEK Cemile 
Published: March 2019

Dünyadaki siyasi, ekonomik, sosyal ve teknolojik gelişmelere bağlı olarak konaklama işletmelerinin varlıklarını sürdürebilmek için zorluklar yaşadığı gözlemlenmektedir. Günümüzde konaklama işletmelerinin faaliyetlerini başarılı bir şekilde devam ettirebilmeleri için güçlü finansal bir yapıya sahip olmaları gerekmektedir. Bu bağlamda, finansal başarısızlık riskinin konaklama işletmeleri açısından ölçülmesi ve yönetilmesi önem arz etmektedir. Bu araştırmanın amacı, Borsa İstanbul’da (BİST) işlem gören konaklama işletmelerinin 2012-2017 yıllarına ait finansal başarısızlık risklerinin Beaver modeliyle ölçülmesidir. Bu amaçla Borsa İstanbul’da (BİST) işlem gören 11 konaklama işletmesi, Beaver modelinin değişkenlerine göre analiz edilmiştir. Analiz sonucunda, BİST konaklama işletmelerinin bazılarının uzun vadeli yükümlülüklerini karşılamada yetersiz olduğu, net çalışma sermayelerinin negatif olduğu, karlılıklarının düşük olduğu, nakit akışlarının yetersiz olduğu, finansal kaldıraç düzeylerini ise etkin kullanmaya çalıştıkları sonucuna ulaşılmıştır.
First report of Sarconema eurycerca (Filarioidea) in mute swan (Cygnus olor) in Poland – the case report
Authors: Michalski M. M. , Gałęcki R. , Siedlecka K. 
Published: March 2019

Summary
Mute swans (Cygnus olor) of the Anatidae family are common in wetlands of Europe. They winter in Africa, Asia and some parts of Europe. The species is exposed to many pathogens in its places of residence, including parasites possibly introduced from tropical countries by other species of birds that take long wanderings and occupy a similar ecological niche. One such case is the infection of the Sarconema eurycerca, nematode belonging to the Filarioidea family. It invades the bird’s myocardium and, according to some authors, this nematode may be one of the main causes of swans’ deaths. The material for the present study was an approximately 2 year old female mute swan, which during the flight fell suddenly to the ground in Pomorskie Voivodeship (Poland, 53°50′18″N 18°12′54″E) in November. During the examination and medical observation, weakness, diarrhea and infestation with lice were found. The cause of its eventual death was attributed to a failure of the circulatory system. Post mortem, two abscesses with diameters of 2-3 cm were found in its liver parenchyma. Three nematodes were visible in the epicardium and many more in myocardium. Upon cutting open the heart, small yellowish foci, about 1 mm in diameter were scattered over valves. On the basis of morphological features, infection by Sarconema eurycerca was concluded. As far as we are aware, in Poland there were no earlier reports of this parasite infecting a swan.
Two new species of the genus Coomansinema Ahmad and Jairajpuri, 1989 (Nematoda: Dorylaimida) with a key to its species
Authors: Ahmad W. , Mushtaq P. , Shahnaz  , Kumar S. 
Published: March 2019

Summary
Two new species of the genus Coomansinema Ahmad and Jairajpuri, 1989 are described and illustrated. C. japonicum n. sp. is characterized by having medium size body (L= 1.40 – 1.45 mm); lip region truncate with completely amalgamated lips; amphideal fovea goblet – shaped; 16 – 20 μm long odontostyle; 23 – 25 μm long odontophore; comparatively anterior position of the second pair of pharyngeal glands; amphidelphic female genital system; longitudinal vulva; males with 48 – 54 μm long spicules; 7 – 8 spaced ventromedian supplements and tail long filiform in female and short conoid in male. C. longicaudatum n. sp. is characterized by having medium size body (L= 1.1 – 1.3 mm); lip region truncate, continuous with completely amalgamated lips; amphideal fovea cup – shaped; 16 – 17 μm long odontostyle; 19 – 20 μm long odontophore; comparatively anterior position of the second pair of pharyngeal glands; amphidelphic female genital system; transverse vulva, intestinal – prerectum junction with a tongue – like structure and 210 – 269 μm long filiform tail. A key to its seven valid species is provided.