bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrategias activas y metacognitivas en la enseñanza aprendizaje de las matemáticas en bachillerato
Authors: Lutuala Faz Vilma Verónica 
Published: October 2024

Introducción: este estudio revisa la efectividad de las estrategias activas y metacognitivas en la enseñanza de matemáticas en bachillerato. Objetivo: el objetivo es mejorar el rendimiento académico y desarrollar habilidades de pensamiento crítico y resolución de problemas en los estudiantes. Metodología: la metodología utilizada fue una revisión bibliográfica de estudios empíricos y teóricos publicados entre 2016 y 2024. Resultados: los resultados evidencian que la implementación de estrategias activas y metacognitivas contribuye significativamente al aumento del rendimiento académico, una mejor comprensión conceptual, mayor motivación y desarrollo de habilidades de resolución de problemas en matemáticas. Conclusión: se concluye que estas estrategias son efectivas para mejorar los resultados educativos y promover un desarrollo integral de los estudiantes. Asimismo, se recomienda que los docentes reciban formación continua en estas estrategias para garantizar su correcta implementación en el aula. Esta revisión está enmarcada dentro del campo de la educación, específicamente en la didáctica de las matemáticas, y se presenta como una revisión sistemática de la literatura, siendo un artículo original. Área de estudio general: educación. Área de estudio específica: didáctica de las matemáticas. Tipo de estudio: Revisión Bibliográfica.
Pemodelan Gerak Menggelinding Pada Lintasan Roller Coaster Sederhana
Authors: Wijayanto Mirda Prisma , Saputra Aji 
Published: October 2024

Roller coaster merupakan salah satu jenis wahana permainan berupa kereta yang digerakkan dengan kecepatan tinggi pada lintasan berkelok-kelok dan memiliki ketinggian yang berbeda di atas permukaan tanah. Salah satu masalah yang sering dialami oleh roller coaster adalah terjadi kecelakaan dengan terlemparnya kereta dari lintasan ketika meluncur dengan kecepatan tinggi, seperti yang terjadi pada 14 April 2024 di Taman Kyai Langgeng Eco Park. Pada penelitian ini, kami mempelajari pemodelan gerak menggelinding pada lintasan roller coaster sederhana yang dimodelkan sebagai tiga lintasan setengah lingkaran dengan jari-jari 2R, R, dan R yang terhubung satu sama lain. Penelitian ini bertujuan untuk menentukan syarat ketinggian awal lintasan agar kereta tidak terlempar setelah melewati ujung lintasan, menghitung total waktu yang dibutuhkan untuk berhenti, dan mensimulasikan fungsi posisi dan energi mekanik sistem roller coaster terhadap waktu. Berdasarkan hasil perhitungan didapatkan bahwa syarat ketinggian awal lintasan agar kereta yang dimodelkan sebagai bola pejal tidak terlempar setelah melewati ujung lintasan adalah , dan waktu total yang diperlukan bola hingga berhenti adalah . Berdasarkan hasil simulasi grafik energi mekanik terhadap waktu, didapatkan bahwa peristiwa dinamika gerak menggelinding bola pejal pada lintasan roller coaster sederhana memenuhi hukum kekekalan energi.
Deep learning enabled exercise monitoring system for sustainable online education of future teacher-trainers
Authors: Omarov Nurlan , Omarov Bakhytzhan , Mamutov Quwanishbay , Kissebayev Zhanibek , Anarbayev Almas , Tastanov Adilbay , Yessirkepov Zhandos 
Published: October 2024

IntroductionIn recent years, the importance of effective training methods for future physical education teacher-trainers has grown significantly, particularly in the context of online education.MethodsThis research introduces a pioneering Deep Learning Enabled Exercise Monitoring System aimed at enhancing the online education experience for these trainers. The study employs a skeleton-based approach utilizing the PoseNet model to monitor and provide real-time feedback on physical exercises such as pull-ups, push-ups, sit-ups, squats, and bicep workouts. The system achieves a remarkable accuracy rate of 99.8% by analyzing key skeletal points extracted from video frames, addressing the challenge of ensuring correct exercise execution without physical supervision–a common issue in remote learning environments.ResultsTo validate the system’s effectiveness, data was collected through a series of controlled experiments involving various exercises. The system’s design focuses on low-resource requirements, making it accessible and sustainable for diverse educational contexts.DiscussionThe findings demonstrate the system’s potential to revolutionize online physical education by offering a balance of technological innovation and educational utility. This research not only elevates the quality of training for future educators but also contributes to the broader field of sustainable digital education technologies.
Syncing the brain’s networks: dynamic functional connectivity shifts from temporal interference
Authors: Zhu Zhiqiang , Tang Dongsheng , Qin Lang , Qian Zhenyu , Zhuang Jie , Liu Yu 
Published: October 2024

BackgroundTemporal interference (TI) stimulation, an innovative non-invasive brain stimulation approach, has the potential to activate neurons in deep brain regions. However, the dynamic mechanisms underlying its neuromodulatory effects are not fully understood. This study aims to investigate the effects of TI stimulation on dynamic functional connectivity (dFC) in the motor cortex.Methods40 healthy adults underwent both TI and tDCS in a double-blind, randomized crossover design, with sessions separated by at least 48 h. The total stimulation intensity of TI is 4 mA, with each channel’s intensity set at 2 mA and a 20 Hz frequency difference (2 kHz and 2.02 kHz). The tDCS stimulation intensity is 2 mA. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected before, during, and after stimulation. dFC was calculated using the left primary motor cortex (M1) as the region of interest (ROI) and analyzed using a sliding time-window method. A two-way repeated measures ANOVA (group × time) was conducted to evaluate the effects of TI and tDCS on changes in dFC.ResultsFor CV of dFC, significant main effects of stimulation type (P = 0.004) and time (P &lt; 0.001) were observed. TI showed lower CV of dFC than tDCS in the left postcentral gyrus (P &lt; 0.001). TI-T2 displayed lower CV of dFC than TI-T1 in the left precentral gyrus (P &lt; 0.001). For mean dFC, a significant main effect of time was found (P &lt; 0.001). TI–T2 showed higher mean dFC than tDCS-T2 in the left postcentral gyrus (P = 0.018). Within-group comparisons revealed significant differences between time points in both TI and tDCS groups, primarily in the left precentral and postcentral gyri (all P &lt; 0.001). Results were consistent across different window sizes.Conclusion20 Hz TI stimulation altered dFC in the primary motor cortex, leading to a significant decreasing variability and increasing mean connectivity strength in dFC. This outcome indicates that the 20 Hz TI frequency interacted with the motor cortex’s natural resonance.
Association between dietary calcium intake and constipation in a metabolic syndrome population: evidence from NHANES 2005–2010
Authors: Zhu Li , Yang Long , Liang Zonghua , Shi Wen , Ma Ming , Chen Jingbo , Abdula Zulipikaer , Gong Xuchen 
Published: October 2024

BackgroundThe global prevalence of Metabolic Syndrome (MetS) is increasing, primarily characterized by abdominal obesity, which significantly heightens the risk of cardiovascular diseases, gastrointestinal disorders, and cancers. Constipation is a common gastrointestinal issue that impacts both physiological and psychological health and worsens with age. Calcium, an essential mineral vital for human health, has been proven to be crucial not only for bone health but also beneficial for gastrointestinal health. However, the results regarding its impact on constipation are inconsistent. This study aimed to investigate the relationship between dietary calcium intake and constipation in individuals with MetS.MethodsThis cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2010. Participants were assessed for MetS based on the International Diabetes Federation (IDF) criteria. Dietary calcium intake was evaluated through 24-h dietary recalls, and constipation was defined based on the frequency of bowel movements recorded in the bowel health questionnaire. The relationship between calcium intake and constipation was explored using logistic regression models with adjustment for covariates, and restricted cubic spline analyses were also used to investigate nonlinear relationships.ResultsThe study included 4,838 adult participants with MetS. Adjusted logistic regression revealed that an increase in dietary calcium intake was significantly associated with a reduced risk of constipation (OR: 0.562, 95% CI: 0.379 to 0.835, p = 0.006). Compared to the lowest quartile, the highest quartile of dietary calcium intake significantly decreased the risk of constipation (OR: 0.282, 95% CI: 0.115 to 0.691, p = 0.008). Results from the restrictive cubic spline analysis indicated a negative linear association between dietary calcium intake and constipation risk (non-linearity p = 0.704).ConclusionThe findings suggested that increased dietary calcium intake is associated with a decreased risk of constipation among MetS patients, emphasizing dietary calcium as a potentially modifiable factor for managing gastrointestinal symptoms in this population.
Association between dietary fiber intake and suicidal ideation: a cross-sectional survey
Authors: Huang Huaying , Fu Jianjiong , Lu Keyu , Fu Yaming , Zhuge Pan , Yao Yu 
Published: October 2024

BackgroundDietary fiber is beneficial for improving mental health. However, few studies have evaluated the relationship between fiber-rich food and suicidal ideation. Thus, we aimed to assess whether dietary fiber consumption was associated with the risk of suicidal ideation.MethodsData of 21,865 American adults were retrieved from the National Health and Nutrition Examination Survey (NHANES). Logistic and restricted cubic spline regression analyses were performed in order to evaluate the association of dietary fiber intake with suicidal ideation, as indicated by item nine of the nine-item Patient Health Questionnaire (PHQ-9). These analyses took into consideration several confounding factors that may potentially influence the results.ResultsHerein, we detected an L-shaped association between dietary fiber intake and the risk of suicidal ideation. For the most conclusive model, an increase of 1 g/1000 kcal/d in dietary fiber intake was accompanied by a 5% reduction in the risk of suicidal ideation. The inflection point of the L-shaped association was located at 7.8 g/1000 kcal/d. When dietary fiber intake exceeded the above level, the risk of suicidal ideation no longer decreased.ConclusionOur findings of reduced risk of suicidal ideation in people with higher dietary fiber intake suggest the potential clinical and public health value of dietary fiber. Interventional investigations are warranted to prove whether adhering to a high-fiber diet prevents and reduces suicidality.
Evaluation of the positional reproducibility of sedation versus non-sedation state in pediatric radiotherapy: a retrospective study
Authors: Lei Zhanquan , Shi Yuequan , Liu Yiqun , Gao Bo , Shao Kongfeng , Lin Xijin , Wu Lizhen , Yao Zhaojie 
Published: October 2024

ObjectiveTo assess the positional reproducibility of sedated and non-sedated pediatric tumor patients during radiotherapy through a retrospective analysis of cone-beam computed tomography (CBCT) and planned computed tomography (CT) scan data.MethodsThe positional reproducibility of 40 pediatric tumor patients, aged 2 to 17 years with a median age of 4.5 years, who received radiotherapy under sedated and non-sedated states was retrospectively compared. The first CBCT images obtained during CT-based treatment planning were analyzed. The analysis encompassed six-dimensional positional changes, including vertical (Vrt), longitudinal (Lng), lateral (Lat), rotational (Rtn), pitch, and roll directions. Kolmogorov-Smirnov Z nonparametric rank-sum testing was employed to evaluate the positional deviations, considering absolute values regardless of directionality. Data were further stratified based on different fixation methods used during treatment.ResultsSedated patients exhibited significantly smaller positional deviations in Vrt, Lng, Lat, and Rtn directions in the body membrane group compared with their non-sedated counterparts (P&lt;0.05). Similarly, sedated patients demonstrated reduced positional deviations in Vrt, Lng, Lat, Rtn, pitch and Roll directions in the head and neck group compared with non-sedated patients (P&lt;0.05). Meanwhile, compared with vacuum bag plus body membrane fixation, the head and shoulder film fixation technique proved superior in terms of positional reproducibility during sedated treatment, specifically in Vrt, Lng, Lat, Pitch, and Roll directions (P&lt;0.05). Similarly, compared with the alternative fixation method, the head and shoulder film fixation method showed better positional deviations in six-Dimensional directions in non-sedated patients (P&lt;0.05).ConclusionWhile sedated radiotherapy may offer advantages in terms of positional reproducibility, the present study underscores the importance of considering non-sedated radiotherapy as a viable option for pediatric tumor patients. Non-sedated treatment not only provides effective tumor control but also mitigates the psychological trauma and long-term side effects associated with repeated sedative drug use. Future studies should further explore the optimal sedation and fixation strategies for pediatric radiotherapy.
Biogenically synthesized gold nanocarrier ameliorated antiproliferative and apoptotic efficacy of doxorubicin against lung cancer
Authors: Albulaihed Yazeed , Mishra Prakriti , Saeed Mohd , Alabdallah Nadiyah M. , Ginawi Tarig , Ansari Irfan Ahmad 
Published: October 2024

IntroductionConventional chemotherapy treatment is commonly linked to significant side effects due to high therapeutic doses. In this regard, nanoformulations with chemotherapeutic medications hold promise in enhancing drug effectiveness through the reduction of therapeutic dosages, thereby mitigating the potential for adverse side effects. Because of numerous applications in the biomedical arena, there has been a rising interest in developing an environmentally acceptable, long-lasting, and affordable technique for the production of gold nanoparticles. In this particular context, the incorporation of plant extracts in the production of metallic nanoparticles has garnered the interest of numerous scholars. Here, we report the synthesis of gold particles by the green method using Cannabis sativa L. leaf extract and their conjugation with doxorubicin.MethodsThe gold nanoparticles were synthesized by using Cannabis sativa extract and were characterized with various biophysical techniques. Subsequently, gold nanoparticles were conjugated with doxorubicin and their efficacy was tested on A549 cells.Results and DiscussionThe biogenic synthesis of gold nanoparticles was ascertained through an absorption peak at a wavelength of 524 nm, and it was shifted to 527 nm when conjugated with doxorubicin. Nanoparticles were found to be stable exhibiting a zeta potential value of −20.1 mV, and it changed to −12.7 mV when loaded with doxorubicin. The hydrodynamic diameter of nanoparticles was determined to be 45.64 nm and it was increased to 58.95 nm when conjugated with the drug. The average size of nanoparticles analyzed by TEM was found to be approximately 17.2 nm, while it was 23.5 nm in the case of drug-nanoconjugate. Moreover, there was a significant amelioration in the antiproliferative potential of doxorubicin against lung cancer A549 cells when delivered with gold nanocarrier, which was evident by the lower IC50 and IC75 values of drug-nanoconjugates in comparison to drug alone. Furthermore, the inhibitory effect of drug-nanoconjugates and drug alone was characterized by alteration in the cell morphology, nuclear condensation, increased production of reactive oxygen species, abrogation of mitochondrial membrane potential, and enhanced caspase activities in A549 cells. In sum, our results suggested enhanced efficacy of doxorubicin-gold nanoconjugates, indicating effective delivery of doxorubicin inside the cell by gold nanoparticles.
Current perspectives and trends in acupuncture for sleep disorders: a bibliometric analysis
Authors: Huang Yi , Ying Xihan , Zhang Jieqi , Hu Rong , Chen Yi , Wu Lei , Chen Bowen , Zhang Kai , He Kelin , Ma Ruijie 
Published: October 2024

BackgroundLimitations of conventional treatment methods for sleep disorders have driven the use and development of complementary and alternative therapies such as acupuncture. However, despite the surge in related studies, there is still a lack of visual analysis and detailed elaboration regarding the current status, international collaborations, and research hotspots of acupuncture for sleep disorders.MethodsWe conducted a bibliometric analysis of publications on acupuncture for sleep disorders using the Web of Science Core Collection database from 2004 to 2023. We utilized the R package “bibliometrix” to count publications and citations, VOSviewer to create an inter-institutional referencing network, and CiteSpace to identify references and keywords with the highest citation bursts. Additionally, we employed a bibliometric online analysis platform designed for analyzing national partnerships.ResultsA total of 432 pertinent papers were retrieved, with China being the most prolific contributor, accounting for 61.6% of the publications, followed by the United States and South Korea. Despite China’s high output, its average article citation rate and proportion of international collaborations were notably lower than those of the United States. Key research institutions such as the University of Hong Kong, Shanghai University of Traditional Chinese Medicine, Memorial Sloan Kettering Cancer Center, and Guangzhou University of Chinese Medicine have played significant roles in this field. Among authors, Ka-Fai Chung from the University of Hong Kong stood out as the most productive. In terms of journals, MEDICINE was the most active, while SLEEP was considered the most authoritative. The clinical effects of acupuncture for insomnia have garnered significant attention in recent years, with electroacupuncture emerging as the prevailing technique for addressing sleep disorders.ConclusionThis bibliometric study effectively outlines the basic framework of knowledge surrounding acupuncture for sleep disorders over the past two decades, covering publications, countries, institutions, authors, and sources. It highlights promising clinical effects and underlying mechanisms of acupuncture, particularly for secondary insomnia and specific sleep disorders like restless legs syndrome. Moving forward, the focus and challenge for future research lie in the development of standardized study protocols and harmonization of efficacy assessment metrics.
Ultrasound-assisted extraction of itraconazole from pellets: an efficient approach for the recovery of active pharmaceutical compounds from solid dosage forms
Authors: Ferreira Patricia G. , Lima Carolina G. S. , de Moraes Marcela C. , da Silva Fernando de C. , Futuro Débora O. , Ferreira Vitor F. 
Published: October 2024

IntroductionItraconazole is a widely used broad-spectrum antifungal drug on a global scale. However, its poor water solubility necessitates the development of advanced formulations for its effective use. Currently, itraconazole is available commercially in capsule form, with pellets containing the active drug. The extraction of itraconazole from these granules is often required when developing new formulations. Extracting active pharmaceutical ingredients (APIs) from pellets is crucial in ensuring precise and consistent dosing when producing pharmaceutical dosage forms. Surprisingly, no existing methods for extracting itraconazole from pellets have been reported thus far.ObjectiveTherefore, this study aimed to develop and evaluate an efficient method for extracting this API from pellets.MethodsTwo extraction methods were assessed: conventional Soxhlet extraction and ultrasound-assisted extraction.Results and DiscussionThe results demonstrated that ultrasound-assisted extraction significantly outperformed the conventional method, yielding higher amounts of itraconazole with a high purity level of 96.8%.
Mycobacterium abscessus pulmonary infection and associated respiratory function in cystic fibrosis-like βENaC mice
Authors: Pearce Camron M. , Shaw Timothy D. , Podell Brendan , Jackson Mary , Henao-Tamayo Marcela , Obregon-Henao Andres , Lam Ha , Alshiraihi Ilham M. , O'Neal Wanda , Livraghi-Butrico Alessandra , Hickey Anthony J. , Meibohm Bernd , Gonzalez-Juarrero Mercedes 
Published: October 2024

IntroductionChronic pulmonary infection with Mycobacterium abscessus (M. abscessus) is a significant cause of morbidity and mortality in people with cystic fibrosis (CF). Developing an animal model of M. abscessus pulmonary infection, especially under CF conditions, is essential to understanding clinical pulmonary M. abscessus infection. βENaC transgenic mice are known to develop spontaneous CF-like disease characterized by airway mucus obstruction and inflammation. The aim of this study was to evaluate the suitability of βENaC mice as a preclinical model and characterize their respiratory function during M. abscessus lung infection.MethodsMice received an intrapulmonary aerosol of M. abscessus using a high-pressure syringe device (Penn-Century) for subsequent characterization of disease progression and respiratory function. Whole body unrestrained plethysmography (WBP) data was collected to monitor lung function and endpoints determined organ bacterial burden and associated pathology.ResultsEndpoint CFU data in the lung and spleen showed that there was no significant difference in bacterial clearance between βENaC and WT mice. WBP data showed an impairment in overall respiratory function during and after M. abscessus infection in both strains of mice. Interestingly, even in wildtype control mice, lung dysfunction persisted after bacterial clearance.DiscussionEven with CF-like features, the βENaC transgenic mice cleared M. abscessus at a similar rate than WT mice, however, the associated respiratory monitoring revealed that there are long-term implications of M. abscessus lung exposure. The clear decline in respiratory function, even after M. abscessus clearance, suggests that WBP coupled animal modeling provides important insight that is relevant to disease burden and treatment efficacy. The M. abscessus clearance in the βENaC mice may help improve the fields understanding of CF-modulated immune deficiencies in M. abscessus pulmonary infection.