bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foxm1 Transcription Factor Regulates Lung Adenocarcinoma Development
Authors: Liang Sheng-Kai , Chao Shen-Yang , Li Chien-Cheng , Ip Ka-U , Lin Yi-Kai , Hsu Chia-Chan , Hsu Pei-Chia , Wang I-Ching 
Published: June 2019

Abstract
Foxm1 is a potential transcription factor that is abundantly expressed in highly proliferative human lung cancer cells. Foxm1 also strongly correlates to lung fibrosis, epithelial-mesenchymal transition (EMT) to enhance metastatic program during the lung adenocarcinoma development. Foxm1 plays a pivotal role in controlling cell cycle phase through the G1-S-G2 checkpoint. The increasing Foxm1 and K-ras oncogene expression significantly associate with tumor growth and poor prognosis that potentially modulate patient’s mortality in a subject with lung carcinoma. The genetic evidence showed that the silencing of Foxm1 resulted in the decrease in lung tumorigenesis. Thus, Foxm1 may contribute in the future as the potential target for cancer therapy by reducing lung fibrosis, EMT, and tumor cell proliferation to improve patient’s survival rate.
Preliminary Study of Immobilized of Cellulase in Silica from the Rice Husk Ash to Hydrolysis Sugarcane Bagasse
Authors: Utomo Yudhi , Yuniawati Nurakhma , Wonorahardo Surjani , Sumari  , Santoso Aman , Kartika Kusumaningrum Irma , Susanti Evi 
Published: June 2019

Abstract
Cellulase in the production of bioethanol from sugarcane bagasse is used to hydrolyze cellulose into reducing sugars. Cellulase needs to be mobilized in a matrix to improve its efficiency because it can be used repeatedly. The purpose of this study was to conduct a preliminary study of potential cellulase immobilized on silica to hydrolyze sugarcane bagasse including the effect of contact time (15, 45, 60, and 75 minutes) and agitation speeds (50, 100, 150, and 200 rpm) on % immobilization and immobilized cellulase activity against sugarcane bagasse, and also decreased activity of immobilized cellulase after repeated use. Contact time and agitation speeds do not affect % immobilization. The optimum contact time and agitation speeds of immobilized cellulase formation based on its activity were at 15 minutes and 100 rpm. Immobilized cellulase activity in cycles II and III decreased to 75.2% and 58.8% compared to the first cycle. Therefore, immobilized cellulase in silica is good enough to hydrolyze sugarcane bagasse and has the potential to be applied as continue system in the production of bioethanol from sugarcane bagasse.
Making Eucheuma cottonii Doty Jam with Various Palm Sugar Concentrations
Authors: Kurniawati E C , Husamah  , Latifa R , Zaenab S , Permana T I , Fauzi A 
Published: June 2019

Abstract
Seaweed is a biological resource abundantly available in Indonesia, yet it has been hardly used or consumed. This study aimed to analyze the influence of palm sugar [Arenga pinnata (Wumb) Merr.] concentration on the quality of Eucheuma cottonii Doty seaweed jam using true experimental research design. The concentrations of palm sugar were 0%, 30%, 40%, 50%, 60%, and 70%. The results showed that there was an effect of palm sugar concentration on the quality of Eucheuma cottonii Doty seaweed jam. The best treatment in this study was palm sugar concentration of 70%. In this treatment, water content, total sugar, and total soluble solids of seaweed jam were 33.60%, 64.89%, and 54.15%, respectively. In general, the addition of palm sugar improves seaweed jam quality.
Human-Whale Shark Interaction: An Inquiry into Standard Operational Procedure (SOP) for Tourist in Papua and East Java
Authors: Imam Dhiyassalam , Kamal Mohammad M. , Fachrunnisa Rifka 
Published: June 2019

Abstract
The provision of the whale shark (Rhincodon typus) protection status imposed us to formulate an effective interception Standard Operational Procedure (SOP) for the visitor as an effort to manage sustainable fisheries resources. The research was conducted using visual underwater survey (VUS) method and direct observation. The SOP formulation was effectively applied in Kwatisore (Papua) and Probolinggo (East Java) beach. However, the SOP was made differently due to the differences in the behavior of whale sharks and also the differences in the water conditions in both places. The groups of whale sharks in Kwatisore frequently interacted with humans. Besides, Kwatisore has also a clear beach that allows the visitor for diving and snorkeling while the Probolinggo beach has turbid water. As a result of those differences, the content of the SOP also was made distinctively. The SOP in Kwatisore summarized the procedure of touching prohibitions, using flash, making noise and safe distance for swimming with the whale shark, whereas the SOP in Probolinggo was made to control the number and speed of boats also the distance between the boat and the whale sharks while the visitor observes them.
Flavonoid Characterization in Ferns from Baluran National Park
Authors: Sri Sulasmi Eko , Faiqohtun Wuriana Zauhara , Suryaningtya Sari Ratna , Rohmawati Uun 
Published: June 2019

AbstractFlavonoids belong to the largest group of a phenolic compound found in plants. The presence of these flavonoids is significant for the plants themselves such as protecting plants from UV-B, insect pests, biotic, and abiotic stresses. More than 10,000 varieties of flavonoids have been already identified. Several plants can synthesize flavonoids, one of which is ferns. Cosmopolitan ferns are found in tropical and subtropical regions like Baluran National Park. The ecosystem in Baluran National Park has components that can show different sensitivity level to the factors influencing the environment, either in terms of biotic and abiotic factors. Same species of plants in different environments can be different significantly in their secondary metabolite content. The primary purpose of this research was to determine the types of flavonoids ferns in Baluran National Park. This study was conducted in April-June 2018. The extraction of samples was conducted using 96% methanol solvent and the analysis using the thin layer chromatography. The results showed the fourth type of flavonoid rutin, hyperoside, quercitrin, and quercertin contained inPseudocyclosorrus ochthodes(Kunze) Holttum,Phymatodes scolopendria(Burm.) Ching.Stenochlaena palustris(Burm.), except routine not found inDryopteris hirtipes(Bl.) Kuntze Beddome.Pteris vittataL. does not contain all four types. Types of flavonoids from ferns in Baluran National Park are routine, hyperoxide, quercitrin and quercetin.
Production and Waste Management for Initiation of Green Campus Program at Universitas Negeri Malang
Authors: Novianti Vivi , Wayan Sumberartha I , Amin Muhammad 
Published: June 2019

Abstract
In 2017, Universitas Negeri Malang (UM) was declared as a green campus, which is a concept developed for environmental management. It is necessary to provide data and information on environmental management at UM to support the green campus. One of them is the problem of waste and its management. The purpose of this study was to determine the amount and type of waste, analyze the factors that affect the production and management of waste, and develop waste management strategies at UM. The research approach included surveys, observations, questionnaires, random interviews on all campus elements in nine faculties. The data were processed and analyzed descriptively. The amount of waste generated at UM was 1.5-2.0 tons per day and increased two times higher at a special event. The garbage produced in the form of organic (50%) and inorganic waste (50%). Organic waste consisted of leaves and food scraps, while inorganic waste included plastic (food wrap and bottles of mineral water), cardboard, and paper. The sorting of the type of garbage only occurred inside the campus; it would be re-mixed in landfills. Therefore, waste management at UM has been dominated by a conventional method (collecting, transporting, and disposing of) with landfilling as the final dumping. Some strategies were needed in the form of building the integrated waste management centers, socialization of sustainable campus waste management, integration of environmental knowledge in specific courses in each study program, and green programs carried out jointly by the campus community to realize UM as a green campus.
The Utilization of Plant Diversity by Tengger Tribe around Bromo Tengger Semeru National Park, East Java, Indonesia
Authors: Rohman Fatchur , Rahyu Lestari Sri , Hari Utomo Dwiyono , Purwanto  , Juma Yusri , Nur Arifah Siti , Annisa Yuslinda 
Published: June 2019

Abstract
Tengger tribe is one of the tribes in Indonesia that live around Bromo Tengger Semeru National Park (BTSNP) area. BTSNP area inhabited by the Tengger tribe people is an area in Indonesia with high biodiversity. The local wisdom of the Tengger tribe is in terms of the use of natural resources for various requirements of their lives. This study aimed to explore the utilization of multiple plants by the Tengger tribe in Ngadas and Ranupani villages around BTSNP. This research used surveys and group discussion (GDF) methods involving traditional leaders and some people of the Tengger tribe. The data obtained were analyzed descriptively and qualitatively. The results showed that the plants used for traditional medicinal materials were 25 species, food sources were 17 species, industrial materials and household were 11 species, building materials were 17 species, ecological functions were nine species, and traditional ritual ceremonies were seven species. The Tengger tribe used the natural resources in the form cultivation plants and non-cultivation plants to support in all aspects of their livelihood.
The Influence of Dominant Bacteria from Various Lakes of East Java, Indonesia on Chlorella sp. Culture
Authors: Prabaningtyas Sitoresmi , Witjoro Agung , Suarsini Endang , Aridowi Dhiyaudin , Safitri Yeni , Sulistiana  , Aribah Dina , Yanis  
Published: June 2019

Abstract
Synergetic bacteria need to be explored which can accelerate the growth of microalgae which have potential as oil producer related to renewable energy. This research aimed to analyze the influence of the dominant bacteria from Ranu Pane (POD code), Ranu Grati (GOD code), Ranu Regulo (ROD code), and the recombinant dominant bacteria from all sampling areas (PGR code) on the growth of Chlorella sp. in co-culture. Also, the individual crosscheck was done by making co-interaction between the predominant bacteria from each and biofuel producing microalgae (Chlorella sp.). The co-culture data between the dominant bacteria species and Chlorella sp. showed that dominant species had different effects on the number of microalgae cells in the co-culture. Thus, co-culture could accelerate the growth of Chlorella sp, extend the log and stationary phases and enhance the environmental carrying capacity.
Sonochemical-Assisted Coprecipitation Synthesis of Body-Centered Tetragonal Mn3O4 Spinel Nanostructures Using Polyethylene Glycol Template Agent
Authors: Hidayat Nurul , Taufiq Ahmad , Sunaryono  , Chuenchom Laemthong 
Published: June 2019

Abstract
The excellent characteristics of Mn3O4 nanomaterials have driven many experts to carry on exploring improved approaches for Mn3O4 fabrication. Herein, Mn3O4 nanostructures have been synthesized via sonochemical-assisted coprecipitation method. Polyethylene glycol (PEG-6000) with various concentrations was employed as a surface coating. The combination of coprecipitation and ultrasonication has led to the formation of Mn3O4 nanoparticles which were well-confirmed by three different characterization instruments, i.e., X-ray diffraction (XRD), scanning electron microscopy (SEM) along with energy dispersive X-ray (SEM-EDX), and Fourier transform infrared (FTIR). The XRD data collection and analysis reveal the presence of single-phase of Mn3O4 spinels. The Rietveld refinement dictates the establishment of tetragonal distortion along the c-axis creating a body-centered tetragonal spinel structure with a space group of I41/AMDS. In addition, the SEM-EDX and FTIR data support the experimental results obtained by XRD.
Catalytic N2O Decomposition over Cu/Mn/Zn Doped Ceo2 Composite Oxides
Authors: Zhang Yuanyang , Guo Yaqiong , Li Na , Feng Yaoyu 
Published: June 2019

Abstract
Cu/Mn/Zn oxides were firstly prepared by coprecipitation with molar ratio of Cu/Zn, 0.17, and Mn/(Cu+Zn) by 0.0∼0.06, respectively. The temperature of N2O conversion ca. 10% over Cu/Zn and Cu/Mn0.03/Zn was 370°C and 325°C, respectively, by using 6.8(v)% N2O+balanced N2, and GHSV of 30000h−1, indicating the addition of manganese oxide could improve Cu/Zn oxide activity on N2O decomposition. The Cu/Mn/Zn doped CeO2 composite oxides were further prepared with molar ratio of Ce/Cu by 0.0∼1.4. The temperature of N2O conversion ca. 10% over Ce1.0/Cu/Mn0.03/Zn was 260°C as same conditions applied over Cu/Zn and Cu/Mn0.03/Zn samples. Stability test by using simulated mixture, 6.8(v)% N2O+5.0(v)% O2+3.0(v)% H2O+balanced N2, 580°C, GHSV of 30000h−1, showed that N2O conversion remained stable. Characterization demonstrated that the synergistic action of active components was the main origin of Ce1.0/Cu/Mn0.03/Zn sample had good performance on N2O abatement.
Pollution Characteristics and Sources of Fine Particles During a Heavy Haze Episode in Winter: A Case Study of Weinan City
Authors: Zhu Y , Cao N , Wei Z , Zhang Y J 
Published: June 2019

Abstract
Single Particle Aerosol Mass Spectrometry (SPAMS) is used to investigated a heavy haze process in Weinan,2017. Firstly, the fine particles (PM2.5) using ART-2a was analysed and clustered into 8 classes: organic carbon (OC), organics and elemental carbon combined particles (ECOC), elemental carbon (EC), heavy metal (HM), high molecular organic carbon (HOC), K-rich, levoglucosan (Lev) and dust. Secondly, positive matrix factorization (PMF) was used to identify the sources of PM2.5. Results from PMF showed that the main six sources of PM2.5 were coal-fired (38.48%), secondary (19.19%), biomass burning (15.04%), industry (9.28%), traffic (5.02%), and dust (5.00%). And it is obvious that the major cause of the atmospheric heavy haze is an unfavorable meteorological conditions such as high humidity and low wind speed, as well as coal-fired pollution and secondary pollution caused by heating and industrial production.
Research and Application of Agricultural Intelligent Standardized Production Management Platform
Authors: Yu Jinying , Ping Yang , Sun Lixin 
Published: June 2019

Abstract
In order to implement the standardization of greenhouse production management model and intelligent early warning mechanism, in this paper, the greenhouse crops such as cabbage and tomato in Beijing Tianjin Hebei region were studied, By studying the standardized process suitable for the safe and efficient production of greenhouse crops cabbage and tomato, a technical knowledge base were established. Combined with the IOT perception system, the author designed the agricultural intelligent standardized production management platform based on the MVC framework. The applicability and practicability of this management platform in the large-scale agricultural park were preliminarily verified, which would help to improve the standardization and scientificity of the production and management of the greenhouse vegetables. The design method of the management platform closely integrated with production management activities has great popularization value.
Research on Comprehensive Benefit Post Evaluation of Photovoltaic Poverty Alleviation Projects Based on FCM and SVM
Authors: Ding Liu , Gege Li , Wei Zeng , Min Sun , Cunbin Li 
Published: June 2019

Abstract
Photovoltaic (PV) Poverty Alleviation makes full use of the solar energy in poverty-stricken areas so as to achieve sTable incomes increase for the poor households for 25 years. It is an advanced mode integrating new energy development, emission reduction and accurate poverty alleviation. Post evaluation of PV poverty alleviation project is of great guiding significance for new energy development planning, poverty alleviation promoting and construction and operation of PV power stations. Under the guidance of the practical experience of PV poverty alleviation in Jiangxi province, China, this paper firstly builds a comprehensive evaluation index system with 7 second-level targets based on the post evaluation theory. Then, considering that projects with different sizes, construction and operation mode have different features in the evaluation, this paper uses pattern recognition method based on fuzzy C-means clustering algorithm and support vector machine to classify the projects. Then comparative analysis is carried out within each class to achieve comprehensive benefits evaluation. The method can reduce the information loss of multi-index weighted aggregation of traditional post evaluation methods. The features of PV poverty alleviation projects are highlighted to help to find the weak points of the projects. So the evaluation results are more scientific and reasonable.
RETRACTED: Solid-state nuclear magnetic resonance study of setting mechanism of β-tricalcium phosphate—inositol phosphate composite cements
Authors: Konishi Toshiisa , Yamashita Kohei , Nagata Kohei , Lim Poon Nian , Thian Eng San , Aizawa Mamoru 
Published: June 2019

Abstract
Solid-state nuclear magnetic resonance (NMR) spectroscopy is a technique, which can be used to provide insight into the chemical structure of non-crystalline and crystalline materials. Hence, the present study aimed to elucidate the setting mechanism of CPC, which was fabricated using β-tricalcium phosphate (β-TCP)—inositol phosphate (IP6) composite powder using NMR In addition, the effect of IP6 on the local chemical structure of the β-TCP-IP6 composite powder and its hardened cement would also be investigated. The 1H→31P heteronuclear correlation NMR spectrum revealed that an amorphous hydrated layer, along with small amount of hydroxyapatite (HA) was formed on the surface of β-TCP during the ball-milling process. Results demonstrated that the IP6 in the hydrated layer on the surface of β-TCP inhibited the formation of HA. Moreover, the setting reaction of the cement was mainly triggered by the dissolution of the amorphous hydrated layer on β-TCP surface, and subsequent precipitation, followed by the inter-entanglement between the HA crystals on the β-TCP.
Absence of giant dielectric permittivity in graphene oxide materials
Authors: Alfonso M , Yuan J , Tardani F , Neri W , Colin A , Poulin P 
Published: June 2019

Abstract
Graphene oxide (GO) is considered as a promising component for electronics because of its unique anisotropy, easy processing and sometimes claimed giant permittivity. The latter would arise from an enhanced electronic polarizability due to the presence of functional groups at the surface and edge of GO flakes. As a matter of fact, a number of publications have reported a very large permittivity of GO materials. Nevertheless, the reported values for the intrinsic relative permittivity vary significantly from a few units to several millions. Such variability raises a critical question on the actual and intrinsic permittivity of GO, and on difficulties of measurements due to the polarization of the electrodes. We presently report impedance spectroscopy characterizations of GO solutions with different solvents. We find very large capacitance at low frequencies, in agreement with previous reports. However, we also show that these results can be interpreted without considering a giant permittivity of GO. Actually, a simple equivalent circuit model allows us to confirm that GO does not have a giant permittivity. We conclude that GO can be used as an electrolyte for supercapacitors, or as a precursor for electrically conductive graphene-based materials, but not as an efficient additive to raise the permittivity of solvents or composites for electronics and energy storage applications.
Meniscus fabrication of halide perovskite thin films at high throughput for large area and low-cost solar panels
Authors: Dai Xuezeng , Deng Yehao , Van Brackle Charles H , Huang Jinsong 
Published: June 2019

Abstract
Halide perovskites have rapidly attracted considerable attention due to unprecedented properties not seen in traditional semiconductors. In addition to their optoelectronic merits, one advantage of perovskite materials is their solution processability, which opens the door to low-cost and high throughput solution coating strategies for the commercialization of perovskite solar cells (PSCs). Here we review perovskite film fabrication by meniscus coating—a simple and readily scalable manufacturing technique, including blade coating and slot-die coating. We outline the fundamental fluid mechanisms of meniscus coating, discuss drying and crystallization of perovskite in the coating process, and provide an overview of recent progress in meniscus-coated PSCs.
Multiple Health Risk Behaviors in Young Adult Smokers: Stages of Change and Stability over Time
Authors: Ramo Danielle E , Thrul Johannes , Vogel Erin A , Delucchi Kevin , Prochaska Judith J 
Published: June 2019

Abstract

Background
Health risk behaviors (HRBs) are common, yet not well understood in young adult smokers.

Purpose
We examined HRB profiles over 12 months in young adult smokers participating in a Facebook smoking cessation intervention clinical trial.

Methods
Participants (N = 500; age M = 20.9 years; 54.6% women) were recruited online and randomized to receive either a 3-month Facebook smoking cessation intervention or referral to Smokefree.gov (control). A Health Risk Assessment determined risk for 10 behaviors at baseline and 3, 6, and 12 months. Latent class analysis (LCA) and latent transition analysis (LTA) were used to identify patterns of HRBs and changes over time.

Results
At baseline, participants reported an average of 5.4 (standard deviation [SD] = 1.7) risk behaviors, including smoking (100%), high-fat diet (84.8%), poor sleep hygiene (71.6%), and low fruit and vegetable intake (69.4%). A 3-class model fit the data best at baseline and all follow-up time points: low risk (28.8% at baseline) with low likelihood of risk on all behaviors except smoking, substance use risk (14.0% at baseline) characterized by heavy episodic drinking, cannabis use, and other illicit drug use, and metabolic risk (57.2% at baseline), with a high percentage of members at risk for a low fruit and vegetable intake, high-fat diet, inactivity, stress, and poor sleep hygiene. Classes were very stable at 3, 6, and 12 months, with few participants transitioning between classes.

Conclusions
Most young adult smokers engaged in multiple risk behaviors, with meaningful clustering of behaviors, and demonstrated stability over a year’s time. In addition to smoking, targets for intervention are co-occurring substance use and metabolic risk behaviors.

Clinical Trials Registration
NCT02207036.
VII — Genealogy, Epistemology and Worldmaking
Authors: Srinivasan Amia 
Published: June 2019

AbstractWe suffer from genealogical anxiety when we worry that the contingent origins of our representations, once revealed, will somehow undermine or cast doubt on those representations. Is such anxiety ever rational? Many have apparently thought so, from pre-Socratic critics of Greek theology to contemporary evolutionary debunkers of morality. One strategy for vindicating critical genealogies is to see them as undermining the epistemic standing of our representations—the justification of our beliefs, the aptness of our concepts, and so on. I argue that this strategy is not as promising as it might first seem. Instead, I suggest that critical genealogies can wield a sort of meta-epistemic power; in so far as we wish to resist the genealogical critic, we are under pressure to see ourselves as the beneficiaries of a certain kind of good luck: what I call genealogical luck. But there is also a resolutely non-epistemic way of understanding the power of critical genealogies, one that is essential, I argue, for understanding the genealogical projects of various theorists, including Nietzsche and Catharine MacKinnon. For critical genealogies can reveal what it is that our representations do—and what we, in turn, might do with them.