bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wellbeing and Learning Post-Pandemic: Amplifying the Voices of Early Secondary School Students
Authors: Baker M`adelaine 
Published: February 2025

Education systems have had to rethink their approach in terms of wellbeing and learning particularly in response to the COVID-19 pandemic and the numerous crises being faced across the world. Learner voice has to be woven through all levels of policy in order to understand the experience of young people, during and since the pandemic. Post-Covid, there is a need for educational reform to articulate the direct link between wellbeing and learner progress and to debate the questions of how we assess learner progress. This journal article draws on a small empirical study of learners, conducted by a headteacher researcher in June 2023, to explore participants’ experiences of learning in their first two years directly following school closures. The paper draws on literature from the original study, completed in 2023 and literature published since. It aims to highlight the voice of the learners as being crucial to research on wellbeing and learning and to amplify the influence of learner voice on further research and policy making.
The research findings demonstrate that, immediately following the pandemic, young people had a heightened awareness of their own wellbeing and the support that they require. This paper challenges educators to consider how the change in young people’s engagement with this aspect of their learning might be used to influence educational reform. The study also highlights the importance of privileging the learner experience with practices that encourage safe articulation of complex feelings.
In terms of learning, the findings suggest that there needs to be a deeper consideration of how and what young people learn, what motivates them to learn and how attitudes both to how and what they learn has changed since the pandemic. While the general discourse of curriculum reform in Scotland is asserted to be in line with the views of the young people, there is a dearth of evidence of young people’s voice influencing policy change at all levels.
Transmisión del psicoanálisis en el aula universitaria
Authors: Sánchez García Mercedes 
Published: February 2025

La pregunta por la transmisión orientó el curso Dispositivos Psicoterapéuticos de la Licenciatura en Psicología del CentroUniversitario Regional, Litoral Norte (CENUR LN). Nos convocó a pensar cómo reciben los conceptos psicoanalíticos las nuevasgeneraciones de estudiantes universitarios formados en el litoral norte del país; revitalizó la pregunta «¿debe enseñarse psicoanálisis en la universidad?», dando paso a los siguientes interrogantes: ¿Cómo aportan al trabajo de transmisión los hallazgos de Viena de los siglos XIX-XX en la formación actual de los/las estudiantes del CENUR? ¿Cómo generar un espacio para la transmisión del psicoanálisis en el aula universitaria? Con el objetivo de reflexionar sobre estas inquietudes, proyectamos una metodología que habilitara la participación y la experiencia grupal, y de cada estudiante en dicho curso. Nuestros resultados dejaron ver que la organización grupal/vincular, el hacer explícitos los afectos entre los/las estudiantes y docentes, generó la posibilidad para comprender un encuadre y posicionamiento analítico que se extendió a las prácticas integrales de los y las estudiantes en territorio. Los resultados aproximan a lo planteado por Laplanche (2006) sobre cómo decir en la universidad sobre psicoanálisis. Nuestraexperiencia buscó un hacer en lo político (Gottlieb, mayo de 2008) al inscribir nuestras prácticas en la enunciación colectiva(Ayouch, 2023).
Spectrum of Mutations in Homologous Recombination DNA Repair Genes in Russian Prostate Cancer Patients
Authors: Иевлева Аглая Геннадиевна , Алексахина Светлана Николаевна , Соколенко Анна Петровна , Отраднова Екатерина Андреевна , Никитина Алиса Сергеевна , Кашко Кира Антоновна , Сёмина Мария Вячеславовна , Шестакова Анна Дмитриевна , Кулигина Екатерина Шотовна , Того Александр Викторович , Имянитов Евгений Наумович 
Published: February 2025

Введение. Повреждения в генах репарации по механизму гомологичной рекомбинации (Homologous Recombination Repair, HRR) играют значимую роль в патогенезе метастатического рака предстательной железы (РПЖ). Диагностика подобных нарушений имеет практическое значение, поскольку опухолевые клетки с дефектами HRR обладают повышенной чувствительностью к ДНК-повреждающим агентам и к PARP-ингибиторам. Цель. Анализ частоты и спектра наследственных и соматических мутаций в основных генах HRR у российских больных РПЖ.
Материалы и методы. При помощи таргетного секвенирования нового поколения в группе из 541 преимущественно агрессивного случая РПЖ была проанализирована последовательность 34 генов HRR. Материалом для анализа служили парные образцы ДНК, выделенные из лейкоцитов крови и архивных опухолевых тканей (n = 430), или только образцы опухоли (n = 61) или нормальных тканей (n = 50).
Результаты. Наследственные или соматические патогенные/предположительно патогенные варианты в каком-либо из 34 генов HRR были обнаружены у 102 из 541 (18,9 %) пациентов, больных РПЖ. У 102 больных была детектирована 121 мутация, большая часть из которых (72/121, 59,5 %) пришлась на герминальные варианты. Наиболее частыми оказались повреждения генов BRCA2 (25/121, 20,7 %), CDK12 (15,7 %), ATM (13,2 %), CHEK2 (11,6 %), NBN (7,4 %), BRCA1 (5,0 %), FANCM (4,1 %), RAD54L (3,3 %). В структуре повреждений BRCA2, CHEK2 и NBN преобладали наследственные дефекты (68,0, 92,9 и 66,7 % соответственно), в то время как 56,3 % обнаруженных вариантов ATM и все мутации CDK12 относились к соматическим нарушениям. Мутации ATM и CDK12 были представлены уникальными вариантами, в гене BRCA2 дважды была обнаружена нонсенс-замена p.Gln2157Ter.
Потеря гетерозиготности в опухолевой ткани или вторая соматическая мутация наблюдались у 9/13 (69,2 %) пациентов с герминальными вариантами BRCA2. Аналогичные показатели для генов ATM, CHEK2, NBN, BRCA1 насчитывают 57,1, 50,0, 40,0, 50,0 % соответственно.
Выводы. Частота мутаций в 34 генах HRR в агрессивных РПЖ составляет около 20 %. До 10 % метастатических РПЖ связаны с наследственными патогенными вариантами в генах BRCA2, CHEK2, NBN, ATM, BRCA1, PALB2. Также около 10 % распространенных РПЖ имеют значимые для выбора терапии наследственные или соматические повреждения генов HRR.
GOAL 12 OF THE NATIONAL JUSTICE COUNCIL AIMED AT ENVIRONMENTAL SUSTAINABILITY
Authors: Mendonça Lidiane Lopes Arriel , Menezes Júnior Eumar Evangelista de 
Published: February 2025

THIS PAPER PRESENTS THE 'STATE OF THE ART' SCHEDULED FOR THE PREPARATION OF A MASTER'S THESISMASTER'S DISSERTATION THAT IS BEING DEVELOPED IN THE STRICTO SENSU POSTGRADUATE PROGRAM IN ENVIRONMENTALENVIRONMENTAL SCIENCES AT THE EVANGELICAL UNIVERSITY OF GOIÁS (UNIEVANGÉLICA). THE IMPORTANCE OFTHE IMPORTANCE OF STUDIES FOCUSED ON GOAL 12 OF THE NATIONAL COUNCIL OF JUSTICE, WHICH CALLS FOR ENVIRONMENTALACTIONS THAT CONVERGE TOWARDS ENVIRONMENTAL SUSTAINABILITY. IN ORDER TO SUCCEED, A DEDUCTIVEAPPROACH WAS USED, ENHANCED BY BIBLIOGRAPHIC AND DOCUMENTARY TECHNIQUES, WHICH DEVELOPED IN A DESCRIPTIVE AND EXPLANATORY
ALLOWED THE RESEARCH TO BE DESCRIPTIVE AND EXPLANATORY NATURE.
Investigating the Effects of Atmospheric Stratification on Coronal Active Region Field Modeling
Authors: Rice Oliver , Prior Christopher 
Published: February 2025

Abstract
Understanding the evolution of the complex magnetic fields found in solar active regions is an active area of research. There exist many different models for such fields, which range in their complexity due to the number of physical effects included in them—one common factor being that they all extrapolate the field up from the photosphere. In this study, we focus on the fact that above the photosphere and below the corona lies the relatively cool and dense chromosphere—which is often neglected in coronal models, due to it being comparatively thin and difficult to model. We isolate and examine the effect including this boundary layer has on a 2.5D class of driven MHD models of an active region eruption. We find that it can result in significant changes to the dynamics of an erupting field far higher in the atmosphere than the chromosphere itself, generally delaying eruptions and increasing the magnetic energy released in each eruption. We also test whether these effects can be approximated using a variation of the more computationally efficient magnetofrictional model, finding a number of simple adaptations of the standard magnetofrictional model, which capture the effect of the chromospheric stratification well.
Spectra of He Isotopes and the 3He/4He Ratio
Authors: Boschini M. J. , Della Torre S. , Gervasi M. , Grandi D. , Jóhannesson G. , La Vacca G. , Masi N. , Moskalenko I. V. , Pensotti S. , Porter T. A. , Quadrani L. , Rancoita P. G. , Rozza D. , Tacconi M. 
Published: February 2025

Abstract
Since its launch, the Alpha Magnetic Spectrometer-02 (AMS-02) has delivered outstanding quality measurements of the spectra of cosmic-ray (CR) species, e
±,

p

¯

, and nuclei (H–Si, S, Fe), which have resulted in a number of breakthroughs. Besides elemental spectra, AMS-02 also measures the spectra of light isotopes albeit within a smaller rigidity range. In this paper, we use the precise measurements of He isotopes and the 3He/4He ratio by AMS-02, together with Voyager 1 data, and investigate their origin. We show that there is an excess in 3He at higher energies compared to standard calculations assuming its fully secondary origin, which may indicate a source of primary 3He, or signify a change in the propagation parameters over the Galactic volume probed by the 3He/4He ratio. We provide updated local interstellar spectra (LIS) of 3He and 4He in the rigidity range from 2 to 40 GV. Our calculations employ the self-consistent GalProp–HelMod framework that has proved to be a reliable tool in deriving the LIS of CR e
−,

p

¯

, and nuclei Z ≤ 28.
Synthesis, molecular docking, and anti-inflammatory evaluation of novel 4-(benzo[d][1,3]dioxol-5-yloxy)-N,N-2-yn-1-amine derivatives as potent cysteinyl leukotriene receptor (CysLT2) antagonists
Authors: Jaber Areej M. , Al-Mahadeen Mohammed M. , Al-Najjar Belal O. , Al-Qawasmeh Raed A. 
Published: February 2025

Cysteinyl leukotrienes (CysLTs), derived from arachidonic acid, play a crucial role in regulating inflammation. We synthesized a novel series of CysLT2 antagonists containing the benzo[d][1,3]dioxole moiety using a synthetic strategy based on the Mannich reaction, resulting in the formation of 4-(benzo[d][1,3]dioxol-5-yloxy)-N,N-2-yn-1-amine. The structures of the synthesized compounds were characterized through NMR and HRMS analyses, and a plausible reaction mechanism was proposed. The inhibitory activities of all new compounds against CysLT2 were evaluated in vitro. Among them, compounds 4d and 4g exhibited the most potent inhibitory effects, with IC50 values of 18.7 μM and 15.5 μM, respectively. These findings were further supported by molecular docking studies, which highlighted the binding interactions of these compounds within the kinase’s active site.
Graphical abstract:
Connaissance incertaine du marché et libéralisme économique. D’Adam Smith à la théorie néoclassique, et retour
Authors: Biziou Michaël 
Published: February 2025

La théorie économique néoclassique a pour objectif de prouver, grâce à la mathématisation de ses raisonnements, que l’équilibre général des marchés par la concurrence peut exister. Elle entend élaborer ainsi une connaissance certaine dont la « main invisible » d’Adam Smith ne serait qu’une prémonition floue. Mais si les néoclassiques parviennent effectivement à cette connaissance certaine, celle-ci s’accompagne d’une double déception : sur le plan scientifique elle aboutit à une impasse, et sur le plan politique elle sert de caution à un libéralisme dogmatique. On suggère alors d’effectuer un retour à Smith, pour y trouver une science économique revendiquant une connaissance incertaine des conséquences inattendues, et une version non dogmatique du libéralisme.
L’apodicticité de l’inadéquat : une contribution phénoménologique au problème de la connaissance incertaine
Authors: Jean Grégori 
Published: February 2025

Suivant en cela le Husserl des Méditations cartésiennes, on considère souvent la phénoménologie comme un « néo-cartésianisme » qui, sur le plan épistémologique, serait à tort ou à raison resté fidèle – ou tributaire – de l’idéal cartésien de la connaissance certaine. Pourtant, sur cette question en particulier comme sur d’autres, la phénoménologie ne s’en est nullement tenue à cet héritage cartésien, et notre conviction est qu’elle a même quelque chose à nous enseigner quant aux mauvaises raisons que nous aurions encore d’y tenir. L’hypothèse que nous avançons dans cet article est en effet que l’une des prétentions de la phénoménologie, y compris lorsqu’elle se présenta comme cartésienne, ne fut pas d’opposer connaissance certaine et connaissance incertaine et de s’installer dans la première en rejetant la seconde, mais de dénoncer cette opposition pour conquérir, comme le proposera également le Wittgenstein des Recherches philosophiques, un champ philosophique d’un tout autre ordre – dont tout le problème sera ici de déterminer s’il permet et a finalement pour but de rendre possible la « connaissance ».
Equitable access to digital higher education for students with disabilities in South Africa
Authors: Zongozzi Johannes N. , Ngubane Sindile A. 
Published: February 2025

Background: The growing reliance on digital learning in South Africa, partly because of the emergence of the coronavirus disease 2019 (COVID-19) and 4IR technologies, risks excluding students with disabilities (SwDs) if measures to adequately support them are not in place.Objectives: The study aims to identify gaps in knowledge, policies, practices and resources, which could impede the full engagement of SwDs. This article utilises the conceptual framework for inclusive digital learning, which comprises three categories of concepts related to inclusive digital learning: (1) defining attributes, (2) antecedents (necessary conditions) and (3) consequences (results). The framework is applied to synthesise the literature, determine the framework’s efficacy, feasibility, and suitability, and demonstrate its value and utility in the actual implementation of inclusive and high-quality higher education for SwDs in South Africa during this era of digital learning.Method: This study reviewed 22 articles (2020–2023) on disabilities, higher education, and digital learning identified through Google Scholar using Boolean operators.Results: The study reveals significant gaps in South African higher education research on institutional policies related to digital access, capacity development, and disability inclusion in teaching and curriculum design.Conclusion: The challenges facing SwDs and the existing research gaps imply that most higher education institutions lack the theoretical knowledge, policies, resources, infrastructure and staff capacity to support SwDs.Contribution: This study exposes gaps in the literature and recommends further research on higher education policies and to establish the potential for policy reform to better support SwDs in the current era of digital learning.
Barriers, facilitators of sports participation and needs of South African Paralympians
Authors: Kunene Siyabonga H. 
Published: February 2025

Background: Despite the transformation initiatives, the inclusion of people with disabilities in sports remains a challenge. Athletes with disabilities (AWDs) in low- and medium-socioeconomic countries are still being left behind, including in South Africa. They are facing various challenges.Objectives: This study aimed to explore barriers and facilitators to sports participation and the needs of AWDs.Method: This was a qualitative study design based on semi-structured interviews. Interviews were conducted with South African Paralympians. Permission was obtained from a physical disability association. Ethical clearance was issued by the University of the Witwatersrand Human Research Ethics Committee. An interview schedule with predetermined questions was used to guide the interviews. Interviews were held face-to-face or online from 20 min to 30 min per interview. All participants gave consent. The data were transcribed verbatim and analysed in themes deductively.Results: A total of 23 athletes participated, 12 of which were females and 11 were males. Participants were mostly Africans (n = 23) with a mean age of 26 years. All had over 5 years of sporting experience. Barriers included: Social stigma, a lack of disability awareness, limited opportunities to participate in sports; limited access to resources and services. Facilitators included: health; belonging; fulfilment, winning, and support from loved ones.Conclusion: Results showed a need to scale up disability inclusion, especially regarding the rendering of healthcare services and making resources available.Contribution: This article provides knowledge that may be useful as a baseline for developing a suitable intervention for AWDs.
Successful self-employment in microenterprise for persons with disabilities in a rural setting
Authors: Monareng Luther L. , Soeker Mogammad S. , Naidoo Deshini 
Published: February 2025

Background: Persons with disabilities are involved in self-employment (vocational rehabilitation) in microenterprises despite key role players not making valuable contributions or using self-employment as a placement option.Objectives: This research aimed to explore profitable self-employment microenterprises for persons with disabilities in rural South Africa.Method: This qualitative research study was conducted in a rural community in KwaZulu-Natal province, South Africa. Purposive and snowball sampling were used to recruit 10 persons with disabilities running profitable microenterprises for an average of 5 years each. Data were collected using a piloted question guide in a face-to-face interview. Thematic analysis followed the hybrid inductive and deductive approaches.Results: Persons with disabilities participated, and 9 out of 10 were males. Two themes emerged. Theme one: Running microenterprises – self-initiated and maintained. They use their hands and minds to start microenterprises that benefit them and their families. Theme two: Multiple key role players should be involved in self-employment. Persons with disabilities perceive various key role players and themselves as having an active role in self-employment to benefit their microenterprises.Conclusion: Persons with disabilities in a rural setting engage in successful self-employment in microenterprises, which they self-initiate and maintain. Roles and responsibilities of persons with disabilities and key role players in and outside the hospital setting are crucial for those in self-employment.Contribution: This research generated contextual data towards the under-researched subject on self-employment for persons with disabilities.
Knowledge and practices of vision screening standards for driving among optometrists in Gauteng province, South Africa
Authors: Tamenti Gloria T. , Rasengane Tuwani A. , Mashige Khathutshelo P. 
Published: February 2025

Background: Despite the existence of vision screening standards, inconsistent implementation of these standards among optometrists persists.Aim: To evaluate the knowledge and practices of optometrists regarding vision screening standards specific to driver fitness assessments.Setting: Gauteng province, South Africa.Methods: A descriptive cross-sectional study employing a quantitative approach was conducted among optometrists via an online survey.Results: A total of 156 optometrists with a mean professional experience of 18.6 years ± 10 years participated in the study. The majority of optometrists (73%) demonstrated knowledge of the minimum vision screening standards required for driving. Male optometrists had higher odds of good knowledge compared to females (OR: 1.84 CI: 1.01 – 3.37, p = 0.048). Most optometrists (89%) adhered to these standards in their clinical practice. There was a significant association between knowledge level and the practice of measuring both visual acuity (VA) and visual fields (VF) (χ2 = 9.358, p = 0.025).Conclusion: While the majority of optometrists (73%) demonstrated knowledge of the minimum vision screening standard required for driving, 89% reported adherence to these standards in practice; it is concerning that 27% lacked sufficient knowledge, and 11% did not adhere to these screening standards.Contribution: The study highlights gaps in the knowledge and practice of vision screening standards among optometrists.
Challenges hindering family involvement in the hospital nursing care of a child with autism
Authors: Williams Neil A. , Sokhela Dudu G. , Ngxongo Thembelihle S.P. 
Published: February 2025

Background: Family involvement is crucial in a child’s treatment; however, many professional nurses still neglect to involve families in their child’s care. Studies have indicated that the perceived lack of family involvement in hospitalised children with autism spectrum disorder (ASD) is a problem in many countries. Few studies have been conducted in Africa with none relating to family involvement, highlighting the need for further research.Aim: To develop in-depth insights into the challenges regarding family involvement in hospital nursing care of children with ASD, in the South African context.Setting: Paediatric wards at selected private hospitals and family homes in the eThekwini District of KwaZulu-Natal.Methods: An interpretative phenomenological analysis method was used. A sample of 10 professional nurses and 10 family members was achieved by purposive sampling. Data were collected from participants using semi-structured in-depth interviews.Results: The following challenges were identified by the participants: the lack of knowledge of nurses regarding ASD, nurses not listening to family, uncaring attitude of nurses, nurses’ lack of time and shortage of nursing staff.Conclusion: Nurses play a pivotal role in overcoming the challenges to family involvement, in the hospital nursing care, of a child with ASD. Making nurses aware of the challenges will help improve family involvement in hospitals nursing for the child with ASD.Contribution: This study added to the body of knowledge by identifying the challenges to the involvement of families in the hospital nursing care of a child with ASD.