bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Neuropeptides of Ocular Immune Privilege, α-MSH and NPY, Suppress Phagosome Maturation in Macrophages
Authors: Benque Isaac J , Xia Pu , Shannon Robert , Ng Tat Fong , Taylor Andrew W 
Published: November 2018

Abstract
The ocular microenvironment has evolutionarily adapted several mechanisms of immunosuppression to minimize the induction of inflammation. Neuropeptides produced by the retinal pigment epithelial cells regulate macrophage activity. Two neuropeptides, α-melanocyte–stimulating hormone (α-MSH) and neuropeptide Y (NPY), are constitutively expressed by the retinal pigment epithelial cells. Together these two neuropeptides induce anti-inflammatory cytokine production in endotoxin-stimulated macrophages and suppress phagocytosis of unopsonized bioparticles. These neuropeptides do not suppress the phagocytosis of opsonized bioparticles; however, they do suppress phagolysosome activation or formation. In this report, we studied the possibility that α-MSH with NPY suppress phagosome maturation within macrophages using opsonized OVA-coated magnetic beads to isolate and analyze the phagosomes. The magnetic bead–containing intercellular vesicles were isolated and assayed for Rab5, Rab7, LAMP1, Iad, and OVA. The macrophages cotreated with α-MSH and NPY were suppressed in Rab7 recruitment to the phagosome with suppression in LAMP1 expression but not in Iad expression. The results demonstrated that the α-MSH/NPY cotreatment suppressed phagosome maturation. In addition, the α-MSH/NPY–cotreated macrophages were suppressed in their ability to Ag stimulate CD4+ T cell proliferation. These results imply a potential mechanism of ocular immune privilege to divert Ag processing to prevent autoreactive effector T cells from binding their target cognate Ag within the ocular microenvironment.
Occupational Loss and Perceived Burden: Addressing Care Partner Needs After Stroke
Authors: Einerson Jackie , Terrill Alexandra 
Published: November 2018

Abstract
Date Presented 4/20/2018
Stroke can lead to occupational loss and increase perceived burden in care partners. Implications of this study suggest that care partner needs must be addressed to enhance occupational participation, improve mental health and vitality, and potentially improve rehabilitation for people with stroke.
Primary Author and Speaker: Jackie Einerson
Additional Authors and Speakers: Alexandra Terrill
Contributing Authors: Beth Cardell, Lorie Richards
Impact of Using Heel Wedges to Reduce Idiopathic Toe Walking in a Child With Autism
Authors: Sidman Kristen , Silva Robert 
Published: November 2018

Abstract
Date Presented 4/20/2018
The purpose of this study was to investigate the impact of using heel wedge inserts to decrease toe walking in a child with autism with insidious toe walking in a school setting. The use of gel heel wedges significantly reduced the instances of toe walking in this child with autism.
Primary Author and Speaker: Kristen Sidman
Additional Authors and Speakers: Robert Silva
Is There a Correlation Between Pain and Participation in Instrumental Activities of Daily Living in People With Fibromyalgia?
Authors: Hokeah Christian , Foy Kathryn , Peguero Frances 
Published: November 2018

Abstract
Date Presented 4/20/2018
This quantitative study examined the correlation between chronic pain and participation in instrumental activities of daily living in people with fibromyalgia through an online survey. A regression analysis indicated a relationship between pain and quality of life.
Primary Author and Speaker: Christian Hokeah
Additional Authors and Speakers: Kathryn Foy, and Frances Peguero
Contributing Authors: Sarah Mbiza, Barbara L. Kornblau, Debora Oliveira
Feasibility of Combining Virtual Reality Motor Rehabilitation With Cognitive Strategy Use for People With Stroke
Authors: Boone Anna 
Published: November 2018

Abstract
Date Presented 4/20/2018
MetacogVR is a new intervention blending top-down, cognitive strategy training and bottom-up, virtual reality motor rehabilitation. Feasibility testing yielded a low recruitment rate, high retention rate, and large effects on measures of activity performance and upper extremity motor performance.
Primary Author and Speaker: Anna Boone
Contributing Authors: Timothy J. Wolf, Jack R. Engsberg
Yoga Improves Fall Risk Factors and Quality of Life in People With Type 2 Diabetes Mellitus
Authors: Schmid Arlene , Malcolm Matthew P. , Atler Karen E. , Grimm Laura A. , Klinedinst Tara , Chop Carol 
Published: November 2018

Abstract
Date Presented 4/21/2018
We examined the impact of an 8-week yoga intervention on quality of life and fall risk factors for people with diabetes. All outcome measure scores significantly improved for participants randomized to the yoga intervention.
Primary Author and Speaker: Arlene Schmid
Additional Authors and Speakers: Matthew P. Malcolm, Karen E. Atler, Laura A. Grimm, Tara Klinedinst, Carol Chop
Contributing Authors: Jen Portz
Feasibility and Effectiveness of Telehealth Home Modification Interventions to Improve Safety and Perception of Performance
Authors: Renda Marnie 
Published: November 2018

Abstract
Date Presented 4/21/2018
It is feasible to provide telehealth home modification interventions using participant-owned devices to improve home safety and perception of performance. Telehealth has the potential to improve access to home modification services, and therefore large-scale studies are warranted.
Primary Author and Speaker: Marnie Renda
A Day Shelter Environment’s Role in Transitioning Out of Homelessness: An Appreciative Inquiry Approach
Authors: Cabrera Kristie , Decker Rachel , Williams Ramneek 
Published: November 2018

Abstract
Date Presented 4/19/2018
This study used an appreciative inquiry approach to examine perceptions of how a homeless day shelter environment influences transitioning out of homelessness and the impact of an occupational therapy environmental intervention to support that transition.
Primary Author and Speaker: Kristie Cabrera
Additional Authors and Speakers: Rachel Decker, Ramneek Williams
Contributing Authors: Catherine Peirce
Occupational Performance and Functional Outcomes in People With Parkinson’s Disease: Lee Silverman Voice Treatment BIG
Authors: Doucet Barbara M , Blanchard Mark 
Published: November 2018

Abstract
Date Presented 4/19/2018
A chart review of people with Parkinson’s disease (PD) who completed a Lee Silverman Voice Treatment BIG program showed positive outcomes in occupational performance and functional hand skills. These novel findings offer evidence for using this program to manage chronic symptoms of PD.
Primary Author and Speaker: Barbara M. Doucet
Additional Authors and Speakers: Mark Blanchard
Sensory Processing Is Related to Social Participation of Preschoolers With Developmental Delays
Authors: Hiranaka Chana , Parham Diane 
Published: November 2018

Abstract
Date Presented 4/19/2018
Sensory features of preschoolers with developmental delays are significantly related to their social participation as measured by the Sensory Processing Measure–Preschool. Practitioners should evaluate sensory features of these children and plan sensory-informed intervention to support participation.
Primary Author and Speaker: Chana Hiranaka
Additional Authors and Speakers: Diane Parham
Contributing Authors: Jane K. Sweeney, Pamella Mullens
An Intervention to Reduce the Impact of Fatigue in People With Heart Failure and Chronic Fatigue: A Randomized Controlled Trial
Authors: Kim Young Joo , Radloff Jennifer , Chiariello Jenny , Faust Nicole , Wilcox Madison 
Published: November 2018

Abstract
Date Presented 4/20/2018
Preliminary findings of a randomized controlled trial on interventions for people with heart failure and fatigue are discussed. This topic advances occupational therapy practitioners’ knowledge on individualized interventions to reduce fatigue impact in people with heart failure and fatigue.
Primary Author and Speaker: Young Joo Kim
Additional Authors and Speakers: Jennifer Radloff, Jenny Chiariello, Nicole Faust, Madison Wilcox
Intimacy and Sexuality After Stroke: Spouse Perspectives
Authors: Kniepmann Kathy 
Published: November 2018

Abstract
Date Presented 4/20/2018
Sexual activity is an activity of daily living that can influence social participation and well-being. Physical, psychological, and cognitive changes from stroke can affect couples’ intimacy and sexual interactions. For this study, we interviewed spouses about their needs, experiences, and perspectives regarding intimacy and sexuality.
Primary Author and Speaker: Kathy Kniepmann
Contributing Authors: Stephanie Kerr
Patient Experiences of Participating in Mind–Body Interventions in an Outpatient Rehabilitation Setting
Authors: Takata Sandy 
Published: November 2018

Abstract
Date Presented 4/20/2018
This study explored the experiences of eight patients with upper extremity disorders who participated in mind–body interventions in outpatient rehabilitation. Using a qualitative descriptive method, four themes emerged, alluding to multiple benefits of holistic practice.
Primary Author and Speaker: Sandy Takata
Contributing Authors: Shawn C. Roll
Impact of Use of a Ride-On Toy Car by Children With Mobility Impairment
Authors: Allegretti Ana , Barnes Karin , Berndt Andrea 
Published: November 2018

Abstract
Date Presented 4/20/2018
This study addressed the need for a readily available technology option that combines the fun and developmental impact of powered mobility for young children with mobility impairment. Ride-on toy cars demonstrated a positive impact on the children’s social and motor development.
Primary Author and Speaker: Ana Allegretti
Additional Authors and Speakers: Karin Barnes, Andrea Berndt
Construct Validity of the Feeding Assessment for Children With Autism
Authors: Ausderau Karla , Al-Heizan Muhammad , Dammann Caitlin , Hope Sarah , Althoff Colleen , Dorrance Katelyn , Hamre Molly , St. John Brittany 
Published: November 2018

Abstract
Date Presented 4/21/2018
Findings from this study provide preliminary confirmation of the construct validity of the Feeding Assessment for Children With Autism, providing researchers and clinicians with a comprehensive and psychometrically sound assessment tool to assess the unique feeding challenges of children with autism.
Primary Author and Speaker: Karla Ausderau
Additional Authors and Speakers: Muhammad Al-Heizan, Caitlin Dammann, Sarah Hope, Colleen Althoff, Katelyn Dorrance, Molly Hamre, Brittany St. John
FITTED: An Evidence-Based Intervention for Adolescents With Executive Function Deficits to Improve Daily Functioning
Authors: Fogel Yael 
Published: November 2018

Abstract
Date Presented 4/21/2018
The FITTED approach was the basis for an individualized evaluation and intervention program that emphasizes personal strengths and weaknesses in daily functions among adolescents with neurodevelopmental disabilities who experience executive function deficits.
Primary Author and Speaker: Yael Fogel
Contributing Authors: Sara Rosenblum, Naomi Josman
GINÁSTICA PARA MULHERES NO INSTITUTO DE CULTURA FÍSICA (1928-1937): PRIMANDO PELA GRAÇA E BELEZA
Authors: Dantas Mônica Fagundes , Mazo Janice Zarpellon , Dias Carolina 
Published: November 2018

O objetivo deste estudo é investigar como se sucedeu a difusão da Ginástica em Porto Alegre, tendo como principal cenário o Instituto de Cultura Física (ICF). Como o ICF foi uma instituição que oferecia atividades ao público feminino, busca-se delinear as concepções de feminilidade subjacentes aos métodos ginásticos ensinados no ICF. Amparado nos horizontes teórico-metodológicos da história cultural, propõe-se uma versão da história do ICF elaborada a partir de fragmentos da memória social registrados nos jornais e documentos da época. No período de 1928 a 1937, alicerçado nos discursos eugenistas e higienistas, o ICF propiciou o desenvolvimento de uma cultura física e artística que atendia aos ideais da mulher burguesa e moderna: saudável, graciosa, feminina.
ESTRATÉGIAS PARA O ENSINO DOS VALORES EM AULAS DE EDUCACÃO FÍSICA
Authors: Ginciene Guy , Matthiesen Sara Quenzer 
Published: November 2018

Resumo: Dada a importância do ensino dos valores na escola, esta pesquisa teve como objetivo investigar, por meio da pesquisa-ação, formas de fazê-lo, sistematizando algumas estratégias passíveis de utilização em aulas de Educação Física. Os resultados apontaram três tipos de estratégias: avaliações diárias para a discussão do comportamento dos alunos; Sport Education para o tratamento dos valores próprios da Educação Física; discussão de valores a partir de vídeos. Essas estratégias se mostraram essenciais para que os valores apareçam de uma forma sistematizada em aulas e não como fruto do acaso, em especial, quando se tem como objetivo formar o cidadão.
Passenger mutations as a target for the personalized therapy of cancer
Authors: Monticelli Maria , Viscovo Marcello , Riccio Guglielmo , Andreotti Giuseppina , Hay-Mele Bruno , Cubellis Maria Vittoria 
Published: November 2018

The American FDA approved the first comprehensive NGS diagnostic assay for cancer at the end of 2017, leading the way to personalised therapy of cancer and the massive employ of bioinformatics (https://www.fda.gov/downloads/medicaldevices/productsandmedicalprocedures/invitrodiagnostics/ ucm584603.pdf ).
In NGS-detected genes from cancer patients, driver and passenger mutations can be distinguished. The former provides a proliferative advantage to cancer cells and are commonly found, the latter do not provide proliferative fitness and are different in different patients. However, some passenger mutations might occur in genes involved in metabolism and could be mildly deleterious for cancer cells. Such deleteriousness could be increased using a specific inhibitor of the mutated protein product. A personalized therapy of cancer could address both driver and passenger mutations. To evaluate to which extent it is possible to address passenger mutations for the cure of cancers, we built a gene/ inhibitor list, crossing DrugBank, a database that combines detailed drug data with comprehensive drug target information, with COSMIC, the catalogue of somatic mutations in cancer. First, we obtained the approved drugs annotated as inhibitors from DrugBank, and the genes encoding their target proteins. We then looked for these genes in COSMIC, to check how many missense mutations have been detected in cancer patient genomes.
Role of Anti VEGF Agent in Management of Primary Pterygium
Authors: Singh Abhinav , Patyal Sagarika , Baranwal Vinod K. , Kapoor Gaurav 
Published: November 2018

Objective:
To assess the role of Anti VEGF agent in management of primary pterygium.

Study Design:
Prospective Study.

Methodology:
This prospective comparative study included twenty (20) eyes with primary nasal pterygium and off label use of a single dose of subconjunctival injection of Bevacizumab (0.05 ml, 1.25 mg) injected in the body of pterygium. The vascularity, thickness and size (in cm2) was recorded at baseline and 08 weeks after injection. The main outcome measures were the change in size, vascularity and thickness.

Result:
There were 16 males (80%) and 04 females (20%), with a mean age of 41.5 yrs. There was no significant difference in the mean surface area of pterygium at different time intervals. However, the thickness and vascularity of the pterygium was significantly reduced. There was a significant difference in the pterygium grading by 2 masked observers at different times. At baseline, there were 14 (70%) grade II and 6 (30%) grade III pterygium. At 08 weeks post injection, there were 7 (35%) with grade I pterygium, 10 (50%) with grade II & 3 (15%) with grade III pterygium. No serious ocular or systemic side defects were observed.

Conclusion:
Single dose subconjunctival injection of bevacizumab resulted in regression of pterygium thickness and vascularity. However, local injection of bevacizumab showed no significant difference in the size of the pterygium at the end of 08 weeks. The long term effect of anti VEGF agent in the management of primary pterygium requires further evaluation.
Complications of Peribulbar Block in the Sitting Posture - An Exploratory Study
Authors: Madhuri Venigalla , Anees Fathima , Sudhakar Potti , Nandish Mashru 
Published: November 2018

Purpose:
To review the complications of peribulbar block (PBB) in sitting posture of the patient.

Methods:
Retrospective analysis of complications in 211 patients who had been given PBB in sitting posture during 1 year period between April 2015 till June 2016 at a tertiary care hospital (Sankara eye hospital), Guntur was done. These included orbital regional anaesthesia for cataract, trabeculectomy, retinal detachment, other vitreoretinal surgeries etc, both in paying OT and non-paying (camp) OT.

Results:
Out of 43,200 patients operated in a year at Sankara eye hospital, Guntur who received PBB in sitting posture, 211 patients (0.48%) had block related complications; bradycardia-77 (0.17%) patients; syncope-46 (0.11%); periorbital haematoma-37 (0.08%); retrobulbar hemorrhage-21 (0.05%); Xylocaine hypersensitivity-16 (0.04%); globe perforation-8 (0.02%); wrong eye block-6 (0.01%). All the above were treated and sufficient preventive measures were taken accordingly.

Conclusion:
Ophthalmologists must be prepared to deal with rare but serious complications that can occur with orbital regional anaesthesia.
Evaluation of Fundoscopic Findings in HIV Positive Patients in Relation to HAART and CD4 Count
Authors: Joshi Ajit Kamalakar , Patel Natasha , Kalita Krishangee 
Published: November 2018

Aim:
To evaluate the fundus findings in patients with HIV in correlation to highly active antiretroviral therapy (HAART) and CD4 count.

Materials and Methods:
It was a hospital based observational study. It was conducted from December 2014 to September 2016 in the Ophthalmology Department, Bharati Hospital, Sangli. A total of 195 registered HIV patients on HAART were selected for the study. Informed written consent of the subjects to participate in the study was taken. Patients of both sexes of any age group were included. Patients who did not give consent for the study were excluded.

Result:
The mean age of study subjects was 40.49 years. 83.6% subjects had a best corrected visual acuity (BCVA) between 6/6 to 6/9 in the right eye, 82.6% had BCVA between 6/6 to 6/9 in the left eye. Visual acuity was below 6/60 in 5.1% subjects. The most common anterior segment pathology was cataract (8.2%), corneal opacity (2.1%), pterygium (2.1%) and pseudophakia. CD4 count above 500 cells/mm3 was seen in 28.7% cases while below 250 cells/mm3 was seen in 29.3% cases. The mean age of study subjects was 40.49 years with 51.8% between 21-40 years. Female predominance was observed in study group with 57.9% females to 42.1% males. The prevalence of ophthalmic manifestations in HIV patients on HAART was observed as 37.9%. Prevalance of posterior segment manifestations was 19.5%. Prevalance of ophthalmic pathology increased as CD4 count decreased (250 cells/mm3).

Conclusion:
In the present study, significant posterior segment manifestations were seen in HIV positive patients on HAART. Low CD4 count is a risk as well as predictor for ocular manifestations. Advent of HAART has reduced the prevalence of ocular manifestations. Routine referral system for ocular evaluation from other medical departments is mandatory for timely diagnosis of the vision threatening conditions. It is therefore recommended that eye care should be a part of medical care in the management of patients on HAART.
Incidence of Clinical and Subclinical Cystoid Macular Edema in Diabetic and Non-Diabetic Patients After Cataract Surgery by Means of Optical Coherence Tomography
Authors: Deshpande Aditi Chinmay , Prabhudesai Nitin , Deshpande Chinmay V. 
Published: November 2018

Purpose:
To evaluate the incidence of clinical and subclinical cystoid macular edema in diabetic and non-diabetic patients after cataract surgery by means of Optical Coherence Tomography (OCT).

Materials & Methods:
A total of 30 eyes of 30 patients (15 diabetic and 15 non-diabetic) aged between 50 and 80 years diagnosed to have cataract were enrolled. Patients were investigated for absence of any evidence of macular edema with OCT before surgery. After undergoing cataract extraction by phacoemulsification with foldable IOL implant, OCT was again carried out at post operative 1st week and 4th week to know the foveal thickness and total macular volume. Similarly distance visual acuity was recorded at post-operative 1st and 4th week on Snellen's visual acuity chart. The comparison was done between visual acuity and OCT readings obtained in non-diabetic and diabetic patients to know the incidence of cystoid macular edema (CME).

Results:
There was no significant change found between foveal thickness measured pre-operatively and post-operatively at 1st and 4th week in diabetic and non-diabetic group but significant increase of total macular volume was found at post operative 4 weeks when compared with baseline in non-diabetic (p=<0.001) and diabetic group (p=0.035). There was a significant correlation found in foveal thickness and visual acuity in diabetic patients at 4th week of surgery.

Conclusions:
This study has shown a low incidence of subclinical CME. OCT sho wed increased macular volume in both groups of patients in a small percentage of cases.
Comparison of Topographic and Biomicroscopic Features Among Symptomatic Keratoconic Eyes
Authors: Prasannakumary C. , Valiyaveettil Babitha , Prabhu Padma B. , Jyothi P. T. 
Published: November 2018

Aim and objectives:
This study tries to estimate the relationship between biomicroscopic features and topographic features of keratoconus.

Design:
Descriptive cross sectional study.

Materials and Methods:
Symptomatic keratoconic patients between the age group of 10-30 years were included in this study. Biomicroscopic examination, retinoscopy and corneal topography were done for the patients and their correlation studied.

Results:
The study group included 92 keratoconic eyes having defective vision. The mean age of patients with keratoconus was 20.08 years (SD ± 4.5), 59% (n=54) were males. This study showed a statistically significant positive correlation between anterior segment findings and corneal topographic features.

Conclusion:
Along with biomicroscopic examination, corneal topographic examination is an important method for diagnosis of keratoconus.
A Rare Case of Keratomycosis Due to Myriodontium keratinophilum
Authors: Kochhar Shivani , Gupta Vishnu Swarup , Sethi Harinder Singh , Capoor Malini R. 
Published: November 2018

Purpose:
To report a rare case of keratomycosis due to Myriodontium keratinophilum, which has not been previously reported.

Materials and Methods:
A 60 year old male patient with pseudophakic bullous keratopathy with rupture bullae and history of use of bandaged contact lens developed a corneal ulcer. Corneal scraping from the base and edge of the ulcer was obtained under slit lamp magnification and smear sent for various aerobic and anaerobic bacterial and fungal cultures such as Gram stain, Giemsa stain, KOH mount, Lacto-phenol Cotton-blue mount, culture on Brain-heart infusion based blood agar, chocolate agar and Sabouraud Dextrose Agar (SDA) to identify the type and time of growth to be able to diagnose the pathognomonic agent causing the keratitis.

Result:
Positive smears and cultures from the corneal scrapings identified the causative agent as Myriodontium Keratinophilum. The clinical improvement was significant with meticulous use of hourly topical natamycin, and oral fluconazole twice a day. The corneal ulcer resolved with the formation of leucomatous corneal opacity. The patient was further registered for penentrating keratoplasty.

Conclusion:
This case report lays emphasis on a thorough microbiological work up to provide insightful information thereby expanding our knowledge and spawning new research organisms which may not have been reported earlier. We hereby report a culture proven case of fungal keratitis due to a very rare species; Myriodontium keratinophilum.