bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful second allogeneic stem-cell transplantation from the same sibling donor for a patient with recurrent hepatosplenic gamma-delta (γ/δ) T-cell lymphoma
Authors: Pan Hui , Huang Jing , Li Jun-Nan , Yang Li , Wang Jian-Yu , Wang Xin , Liu Lin , Yang Ze-Song , Wang Li 
Published: October 2018

Abstract

Rationale:
Hepatosplenic T-cell lymphoma (HSTCL) is a rare but aggressive type of peripheral T-cell lymphoma (PTCL). There is an urgent need for effective treatment due to the poor prognosis of HSTCL. Here, for the 1st time we describe the rare successful case of HSTCL who relapsed after a previous allogeneic stem-cell transplantation (allo-SCT), achieved remission with the second allo-SCT from the same donor.

Patient concerns:
A 24-year-old male, presented with a 2-week history of fever, drenching night sweats and nonquantified weight loss.

Diagnoses:
Laboratory studies, flow cytometry of immunophenotyped, and physical examination results strongly suggested hepatosplenic γ/δ T-cell lymphoma, stage IVB.

Interventions:
We proceeded to an allo-SCT with a human leukocyte antigen (HLA) identical sibling donor. The bone marrow examination and fluorescent in situ hybridization were observed for complete donor chimerism of bone marrow cells on day 34. On day 157 after the initial allo-SCT, the bone marrow examination revealed the relapse of the sinusoidal infiltration with lymphoma cells. Considering the disease persistence, we conducted the second allo-SCT from the same HLA-identical sibling donor immediately.

Outcomes:
Bone marrow examination indicated hematologic recovery without residual lymphoma cells.

Lessons:
Our encouraging outcome suggests that the latter allo-SCT needs to be considered early for patients with disease recurrence, and it also demonstrates that graft-vs-lymphoma conferred by allo-SCT may play an essential role on HSTCL treatment. Furthermore, detecting related genes at diagnosis may have prognostic implications and guidance value for personal chemotherapy program.
Reconstruction of complex nail matrix defect using the homodigital reverse fasciocutaneous flap
Authors: Liu Yang , Li Xiucun , Li Ruijun , Zhang Jiayi , Lu Laijin 
Published: October 2018

Abstract
Reconstruction of complex and severe nail matrix defects with the exposure of bone, tendon or joint continues to be challenging for the surgeon. We present our experience using the homodigital reverse laterodorsal fasciocutaneous flap in the reconstruction of complex nail matrix defects.
Six patients (7 fingers) of complex nail matrix defects with the exposure of bone, tendon or joint were treated with the homodigital reverse laterodorsal fasciocutaneous flap based on the dorsal branches of the proper digital artery. In this study, the composite tissue defect size ranged from 1.0 × 1.5 cm2 to 1.3 × 2.5 cm2. All 6 patients participated in follow-up.
All flaps survived well, and no complications were found postoperatively. The mean size of the flaps was 1.4 × 2.4 cm2 (range, 1.2 × 2.0–1.5 × 3.0 cm2); the mean follow-up period was 8 months (range, 4–15 months); patients’ average time to get back to their former jobs was 4.3 weeks (range, 3–6 weeks) postoperatively. All patients were satisfied with the appearance and functional outcomes of the fingers.
The homodigital reverse laterodorsal fasciocutaneous flap based on the dorsal branches of the proper digital artery is an ideal surgical method to reconstruct the complex and severe nail matrix defect.
A huge completely isolated duplication cyst complicated by torsion and lined by 3 different mucosal epithelial components in an adult
Authors: Xiao-Ming Ai , Jin-Jing Lu , Li-Chen Ho , Lu-Lu Han , Xiong Yue , Hong-Hai Zhang , Nian-Yin Yang 
Published: October 2018

Abstract

Rationale:
Intestinal or enteric duplication (ED) does exit as a rare congenital malformation of the gastrointestinal system clinically. It is a separate entity, but can be communicated with the gastrointestinal tract. It is characterized by a well-developed muscular wall and lumen endowed with ectopic mucosa, simulating a portion of normal bowel. A completely isolated duplication cyst (CIDC) refers to an extremely uncommon variant of ED, which is secluded from the alimentary tract and possesses its own exclusive blood supply. Surgical procedure is the treatment of choice, because most often, a definitive diagnosis can only be confirmed intraoperatively.

Patient concerns:
A 20-year-old male patient presented with a 10-day history of intermittent episodes of abdominal pain. The pain evolved from dull into progressive and intolerable, accompanied by vomiting, nausea, and abdominal distention.

Diagnoses:
Closed-loop small-bowel obstruction with volvulus.

Interventions:
The patient underwent an emergency exploratory laparotomy.

Outcomes:
A huge CIDC was observed upon operation, which was affixed to the mesentery with only a narrow base, just like a pedicle; 720° counterclockwise twisting around its base was definitely noted, provoking the compromised blood supply. Complete excision of the cyst was performed along its base safely without violating the intestinal tract. Furthermore, the ectopic mucosa of the cyst exhibited 3 different epithelial lining components histopathologically.

Lessons:
Clinicians should be aware of the possibility of the existence of a duplication and raise a high index of suspicion in case of equivocal diagnosis, particularly in adult population. A low threshold for surgical management should be recommended in order to prevent lethal outcomes.
Correlation between tripartite motif-containing protein 44 protein expression and the prognosis of postoperative patients exhibiting skin squamous cell carcinoma
Authors: Wu Jian , Guo Nai-Zhou , Cui Lei-lei , Wang Wei , Xiong Cun-quan , Zhang Xue-yan 
Published: October 2018

Abstract
Tripartite motif-containing protein 44 (TRIM44) plays an important role in the development and progression of some human cancers; however, its role in skin squamous cell carcinoma (SCC) remains unknown. The aim of the present study was to investigate TRIM44 expression and clinicopathological significance of TRIM44 in SCC.
Immunohistochemistry (IHC) technique, reverse transcriptase-polymerase chain reaction (RT-PCR) and western blot were performed to evaluate differences in TRIM44 protein expression in SCC and normal skin tissues.
IHC showed that the positive rate of TRIM44 staining in SCC tissues 26.00% (9/30), while the positive rate of normal control group was 83.33% (25/30). The positive rate of TRIM44 staining in SCC tissues is significantly lower than normal skin tissue (P <.01). RT-PCR showed that the positive rates of TRIM44 mRNA expression in SCC tissues were 16.67% (5/30), but the positive rate of normal control group was 86.67% (26/30). TRIM44 mRNA expression in SCC group was significantly lower than that in the normal group (P <.01). Kaplan–Meier survival analysis showed that low expression was associated with poor overall survival in SCC patients (P =.004). Multi-factor survival analysis indicated that both low TRIM44 expression and tumor stage were independent factors affecting the overall survival of patients with SCC (P =.038 and P =.001, respectively). Low expression of TRIM44 in SCC was associated with staging (P =.009 and P =.008, respectively) and metastasis (P =.003 and P =.004, respectively).
The levels of TRIM44 protein and TRIM44 mRNA in SCC are both lowly expressed which is strongly associated with tumor staging, metastasis, and poor survival. And it also is an independent factor affecting the overall survival of patients with SCC.
Thrombotic thrombocytopenic purpura and hemophagocytic lymphohistiocytosis in an elderly man
Authors: Aiempanakit Kumpol , Apinantriyo Benjawan 
Published: October 2018

Abstract

Rationale:
Thrombotic thrombocytopenic purpura (TTP) and hemophagocytic lymphohistiocytosis (HLH) are rare hematologic conditions and have high mortality. Both TTP and HLH result from deregulation of the immune system. There are no published reports of coexisting TTP and HLH in elderly patients.

Patient concerns:
A 67-year-old Asian male presented with altered consciousness and fever for 2 days. Physical examination revealed markedly pale, mild icterus with petechiae and purpura. Initially, TTP was recognized in this patient. Bone marrow studies are suggested for evaluating elderly patients to assess specific causes, especially infection and neoplasm.

Diagnoses:
The TTP was diagnosed based on typical history-related symptoms and a specific laboratory result of very low ADAMTS13 level. The diagnosis of HLH was determined after detection of high levels of ferritin and lactase dehydrogenase, which were confirmed by the presence of hemophagocytosis in the bone marrow.

Interventions:
Systemic corticosteroids and plasma exchange were initiated as specific treatment of the patient.

Outcomes:
The patient died in 3 weeks from ventilator-associated pneumonia.

Lessons:
The HLH should be tested using bone marrow studies and specific laboratory tests in patients with TTP.
The impact of prophylactic cranial irradiation for post-operative patients with limited stage small cell lung cancer
Authors: Chen Meng-yuan , Hu Xiao , Xu Yu-jin , Chen Ming 
Published: October 2018

Abstract
To evaluate the impact of prophylactic cranial irradiation (PCI) on the prognosis of patients who received definitive surgery for surgically resected small cell lung cancer (SCLC).
A retrospective analysis was performed on post-operative SCLC patients treated in Zhejiang Cancer Hospital from January 2003 to December 2015. According to the treatment modality, patients were allocated to PCI group and non-PCI group. Univariate survival analysis was performed by the Kaplan–Meier method. Multivariate survival analysis was performed by a Cox proportional hazards model.
A total of 52 patients were included for analysis, among which, 19 patients were in PCI group and 33 were in non-PCI group. Multivariate analysis revealed that PCI (HR = .330; P = .041) was an independently favorable prognostic factor for the overall survival. The median overall survival (OS) time was 32.9 months in PCI group, and 20.4 months in non-PCI group. The 2-year OS rates were 78.0% and 38.0% in PCI and non-PCI group respectively (P = .023). The brain metastasis-free survival (BMFS) rate at 2-year in PCI group was significantly higher than those of non-PCI group (89.0% vs 53.0%, respectively, P = .026).
In conclusion, PCI might be suggested for limited SCLC patients who received definitive surgery.
Management of postoperative ileus after robot-assisted laparoscopic prostatectomy
Authors: Park Jee Soo , Kim Jongchan , Jang Won Sik , Heo Ji Eun , Elghiaty Ahmed , Rha Koon Ho , Choi Young Deuk , Ham Won Sik 
Published: October 2018

Abstract
To compare different postoperative management methods on the recovery of bowel function after robot-assisted laparoscopic prostatectomy (RALP).
This is a prospective study of 716 patients who underwent RALP at Severance Hospital in Seoul, South Korea, between March 2017 and February 2018. Instructions for the different postoperative management methods (mobilization, abdominal massage, hot pack therapy, and gum chewing) were presented to patients, who subsequently reported when these activities were performed as well as the time to first flatus on a designated form.
There were no significant differences in age, height, weight, body mass index, body surface area, prevalence of hypertension and diabetes mellitus, and in American Society of Anesthesiologists (ASA) scores with respect to early bowel recovery. Prolonged times of surgery and anesthesia significantly caused delays in bowel recovery. The total number and time of mobilization, total time of hot pack therapy, and number of gum chewing were significantly and positively associated with bowel recovery. A Kaplan–Meier analysis showed that all of the postoperative management methods were positively associated with the mean time to first flatus.
Methods of postoperative management (mobilization, abdominal massage, hot pack therapy, and gum chewing) have positive effect on bowel motility after RALP. Furthermore, reductions in the times of surgery and anesthesia could significantly decrease prolonged delays in bowel recovery.
Letrozole for patients with polycystic ovary syndrome
Authors: Guang Hui-juan , Li Feng , Shi Jun 
Published: October 2018

Abstract
This retrospective study investigated the efficacy and safety of letrozole for patients with polycystic ovary syndrome (PCOS).
Totally, 136 cases of infertility women with PCOS were analyzed. Of those, 68 patients received letrozole, and were assigned to Letrozole group. The other 68 cases received clomiphene, and were assigned to clomiphene group. Patients in both groups were treated up to 5 treatment cycles. The primary endpoint included infant outcomes. The secondary endpoints consisted of the number of women in conception, pregnancy, pregnancy loss, and ovulation. In addition, any kinds of adverse events were also recorded.
Cases in the Letrozole group did not show better outcomes neither in primary endpoint (live birth, P = .11; birth weight, P = .95; infant gender, P = .85), nor in secondary endpoints (the number of women in conception, P = .07; pregnancy, P = .12; pregnancy loss, P = .47; pregnancy loss in first trimester, P = .70; and ovulation, P = .09), compared with cases in the clomiphene group. Moreover, no adverse events differ significantly between 2 groups.
This study demonstrated that the efficacy of letrozole is not superior to the clomiphene in patients with PCOS.
The effect of Imaginary Working Qigong on the psychological well-being of college students
Authors: Guo Yu , Xu Mingmin , Ji Meiqi , Wei Zeren , Zhang Jialei , Hu Qingchuan , Yan Jian , Chen Yue , Lyu Jiaxuan , Shao Xiaoqian , Wang Ying , Guo Jiamei , Wei Yulong 
Published: October 2018

Abstract

Introduction:
College students are special populations that are particularly prone to have significantly high level of psychological distress than their community peers. Apparently, the best way to manage stress and mental state is through self-care. The characteristic of Qigong is self-directed and self-healing, which is a traditional Chinese mind-body exercise, which has the potential as a stress management intervention. Imaginary Working Qigong, as a kind of static Qigong, is more perception-oriented and can bring about benign sensations of mind and body so as to eliminate stress completely and induce physiological and mental relaxation. In this study protocol, we will systematically examine the feasibility and acceptability of Imaginary Working Qigong on psychological outcomes of the college students and deeply explore molecular biological mechanisms underlying the effects of mind adjustment induced Imaginary Working Qigong.

Methods/designs:
We will conduct a randomized, assessor and statistician-blinded, parallel-controlled trial exploring the beneficial mind adjustment of Imaginary Working Qigong in college students.
A total of 80 eligible college students from Beijing University of Chinese Medicine will be recruited and randomly allocated into Imaginary Working Qigong training or unaltered lifestyle control group according 1:1 allocation ratio with allocation concealment. Imaginary Working Qigong training will last 8 weeks. The study period is 12 weeks including a 4-week supervised training, 4-week independence training, and a 4-week follow-up. Relevant psychological outcomes measurement will take place at baseline, 5 weeks (at the end of supervised training), 9 weeks (at the end of independence training), and 13 weeks (after the 4-week follow-up period) by blinded independent outcome assessors.

Conclusion:
This is the first randomized controlled trial protocol from the perspective of Qigong connotation to systematically evaluate the effects and relevant molecular mechanism of Imaginary Working Qigong for the mental health of a college student population. If our study demonstrates a significant intervention effect, this would provide preliminary higher-quality evidence and establish a further guidance for the application of Imaginary Working Qigong program among a college student population.

Ethics and dissemination:
The study protocol and consent forms have been approved by the medical and animal experiment ethic committee of BUCM (approval number: BJZYYDX-LL2014005).
Efficacy and safety of electromagnetic acupuncture using an electromagnetic therapy stimulator (Whata153) for the treatment of chronic low back pain
Authors: Oh Seo Young , Kang Jae Hui 
Published: October 2018

Abstract

Background:
Chronic low back pain is one of the major conditions causing serious personal and social difficulties in modern society. There are several noninvasive therapies for chronic low back pain; however, the effects of electromagnetic acupuncture have not been studied. Here, we describe the protocol for a study that will investigate the efficacy and safety of electromagnetic acupuncture for patients with chronic low back pain.

Methods:
The study has been designed as a double-blind, single-center, parallel-arm, sham-controlled, randomized clinical trial. A total of 104 patients with chronic low back pain who meet the criteria for selection and exclusion will be enrolled in a 1:1 ratio in an electromagnetic acupuncture group or a sham group. Sterilized disposable needles will be inserted at 6 acupoints, following which stimulation via an electromagnetic (Whata153) or a placebo (sham) stimulator will be applied. The 2 groups will receive a total of 6 treatment sessions over 3 weeks, with 1 follow-up visit within 3 days after the final treatment. The primary outcome will be the change in the visual analog scale (VAS) score for pain from baseline (visit 1, first treatment session) to the follow-up visit (visit 7, after treatment completion). The secondary outcomes will be as follows: changes in the VAS score for pain from baseline (visit 1) to visits 3 (third session) and 5 (fifth session); changes in the VAS score for pain at all assessment points from baseline (visit 1) to the follow-up visit (visit 7); changes in the Oswestry Disability Index (ODI) from visit 1 to visits 3, 5, and 7; and the change in ODI at all assessment points from visit 1 to visit 7.

Discussion:
The results of this trial are expected to provide important clinical information on the efficacy and safety of electromagnetic acupuncture for patients with chronic low back pain.
Bone regeneration around immediate placed implant of molar teeth with autologous platelet-rich fibrin
Authors: Zhou Jing , Li Xue , Sun Xiaolin , Qi Manlin , Chi Minghan , Yin Lihua , Zhou Yanmin 
Published: October 2018

AbstractRationale:There are some challenges concerning immediate implant placement in molar region. Platelet-rich fibrin (PRF), a second generation platelet concentrate, is an autologous fibrin matrix and contains platelets, growth factors, and leukocytes. It is used for tissue healing and regeneration in periodontal and oral-maxillofacial surgery. We report 2 cases of immediate placed implant of molar teeth with autologous PRF to improve and accelerate tissue healing.Patient concerns:Case 1 was a 38-year-old female patient with masticatory discomfort. Case 2 was a 43-year-old male patient with a demand for his left mandibular posterior tooth restoration.Diagnoses:Through the clinical and radiographic examination, the patient in case 1 was diagnosed with vertical root crown fracture of the maxillary right first molar. The patient in case 2 was diagnosed with residual root of the left mandibular first molar via cone-beam computer tomography and clinical examination.Interventions:The 2 patients underwent extraction of the molar teeth and immediate placed implant of molar teeth with autologous PRF was performed. In case 1, the gap between the implant surface and the socket walls of freshly extracted tooth was filled with PRF mixed with a commercial spongious bone substitute, followed by 2 PRF membranes coverage for protection. In case 2, PRF was used as a sole bone substitute material, placed between immediate implant and the socket wall of freshly extracted tooth.Outcomes:Follow-up of 2 cases revealed successful osseointegration and matured gingiva with optimal form and function.Lessons:The results suggested that PRF could solely serve as a bone scaffold in 4-wall bony defects, or can be combined with xenograft in 3-wall bony defects during immediately placed implants in molar regions, exhibiting excellent biocompatibility and good soft and hard tissue healing.
A giant solid cavernous hemangioma mimicking sphenoid wing meningioma in an adolescent
Authors: Lan Zhigang , Richard Seidu A. , Li Jin , Xu Jianguo , You Chao 
Published: October 2018

Abstract

Rationale:
Central nervous system (CNS) solid cavernous hemangiomas are rare extra-axial anomalies that may sometimes resemble meningiomas. Due to their complex vascular nature, accurate preoperative diagnosis is important to avoid disastrous hemorrhage during operation. To the best of our knowledge this is the first case in an adolescent since all middle cranial fossa hemangioma cases reported in literature are adults in their 40s or 50s and all the pediatric cases are cystic.

Patient concerns:
We present a case of a 14-year-old girl with headache and dizziness for 3 months. She occasionally experienced nausea and vomiting but denied visual disturbances and loss of smell.

Diagnoses:
MRI revealed a lesion that extends to the greater wing of the sphenoid bone as well as the pituitary fossa. Our initial diagnosis was a sphenoid wing meningioma but interestingly, histopathology revealed solid cavernous hemangioma.

Interventions:
The residual tumor was completely removed with 2 sessions of Gamma Knife radiotherapy after surgery.

Outcomes:
We were confronted with excessive bleeding during surgery so we attained subtotal resection. However, the patient recovered well with no recurrence of the tumor.

Lessons:
Our case shows that space occupying lesions involving the cavernous sinus and sphenoid ridged could be easily misdiagnosed as sphenoid wing meningiomas in children and adolescents and even adults therefore great care must be exercised when confronted with this kind of presentation.
Prevalence of monoclonal gammopathy of uncertain significance in chronic myeloid leukemia
Authors: Ouyang Wanyan , Zhao Xiaohong , Lu Shiyun , Wang Zhi 
Published: October 2018

Abstract

Rationale:
The abnormal cell types in chronic myeloid leukemia (CML) and monoclonal gammopathy of uncertain (MGUS) are quite different, being myeloid and plasma cells, respectively. The coexistence of CML and MGUS is an uncommon event, which is seldom reported in literature.

Patient concerns:
A 52-year-old female was diagnosed with CML in April 2001. From November 2006, the patient started on imatinib mesylate and kept a complete hematologic and cytogenetic response for nearly 11 years. During her follow-up on July 7, 2017, thrombocytopenia (35∗109/L) was found. Bone marrow aspiration revealed 6% plasma cell infiltration. Serum immunoelectrophoresis revealed 1.24 g/dL of serum monoclonal (M) protein of IgG-κ type.

Diagnosis:
MGUS was diagnosed because of absence of anemia, hypercalcemia, lytic bone lesions, or renal failure. Immune thrombocytopenia (ITP) was also diagnosed in this patient following the detection of antiplatelet autoantibodies. Complex karyotype and missense mutation in PRDM1 were identified.

Interventions:
Because of her obvious decrease of platelets, she started treatment with thalidomide and prednisone.

Outcomes:
Three months later, bone marrow aspirate showed disappearance of plasma cells. There developed an abrupt decrease in IgG and the absence of M-spike in serum immunoelectrophoresis. The platelet count kept normal during 1 year follow-up.

Lessons:
Karyotypic event and gene mutation found in this case may be the initiation of disease transformation. Administration of thalidomide and prednisone proved effective in this patient.