bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant Whole-Brain Radiation Therapy Compared With Observation After Local Treatment of Melanoma Brain Metastases: A Multicenter, Randomized Phase III Trial
Authors: Hong Angela M. , Fogarty Gerald B. , Dolven-Jacobsen Kari , Burmeister Bryan H. , Lo Serigne N. , Haydu Lauren E. , Vardy Janette L. , Nowak Anna K. , Dhillon Haryana M. , Ahmed Tasnia , Shivalingam Brindha , Long Georgina V. , Menzies Alexander M. , Hruby George , Drummond Katharine J. , Mandel Catherine , Middleton Mark R. , Reisse Claudius H. , Paton Elizabeth J. , Steel Victoria , Williams Narelle C. , Scolyer Richard A. , Morton Rachael L. , Thompson John F. 
Published: September 2019

PURPOSE The brain is a common site of metastasis for patients with high-risk melanoma. Although surgery or stereotactic radiosurgery are highly effective local treatments for a small number of metastases, there is a high risk of developing additional brain metastases. The role of adjuvant whole-brain radiotherapy (WBRT) in reducing new metastases is controversial, with a lack of high-level evidence specifically for melanoma. METHODS In this randomized phase III trial, patients who had local treatment of one to three melanoma brain metastases were randomly assigned to WBRT or observation. The primary end point was distant intracranial failure within 12 months, and secondary end points included time to intracranial failure, survival, and time to deterioration in performance status. RESULTS Between April 2009 and September 2017, 215 patients were randomly assigned from 24 centers. Median follow-up was 48.1 months (range, 39.6 to 68 months). Forty-two percent of patients in the WBRT group and 50.5% of those in the observation developed distant intracranial failure within 12 months (odds ratio, 0.71; 95% CI, 0.41 to 1.23; P = .22) and the rates over the entire follow-up period were 52.0% and 57.9%, respectively (odds ratio, 0.79; 95% CI, 0.45 to 1.36; P = .39). Local failure rate was lower after WBRT (20.0% v 33.6%; P = .03). At 12 months, 41.5% of patients in the WBRT group and 51.4% of patients in the observation group had died ( P = .28), with no difference in the rate of neurologic death. Median time to deterioration in performance status was 3.8 months after WBRT and 4.4 months with observation ( P = .32). WBRT was associated with more grade 1 to 2 acute toxicity. CONCLUSION After local treatment of one to three melanoma brain metastases, adjuvant WBRT does not provide clinical benefit in terms of distant intracranial control, survival, or preservation of performance status.
INDENTATION SIZE EFFECT OF HEAT TREATED ALUMINUM ALLOY
Authors: Petrík Jozef , Blaško Peter , Vasilňaková Andrea , Demeter Peter , Futaš Peter 
Published: September 2019

The aim of the submitted work is to study the influence of applied loads ranging from 0.09807 N to 0.9807 N on measured values of micro-hardness of heat treated aluminum alloy 6082. The influence of applied load on a measured value of micro-hardness was evaluated by Meyer’s index n, PSR method and by Analysis of Variance (ANOVA). The influence of the load on the measured value of micro-hardness is statistically significant and the relationship between the applied load and micro-hardness manifests the moderate reverse ISE. As the temperature of the solution treatment rises, the YS/UTS ratio and also Meyer’s index n, measured and “true hardness“ increase. On the other hand, its effect on the plastic properties of the alloy is ambiguous.
PHENOTYPIC FEATURES OF T REGULATORY CELLS IN EARLY RHEUMATOID ARTHRITIS
Authors: Avdeeva A. S. , Rubtsov Yu. P. , Popkova T. V. , Dyikanov D. T. , Nasonov E. L. 
Published: September 2019

Objective:to investigate the count and characteristics of the phenotype of T regulatory cells (Treg) in the peripheral blood of healthy donors and patients with early rheumatoid arthritis (RA), by using multicolor flow cytometry.Subjects and methods. The investigation enrolled 39 patients with early RA. The percentage and absolute count of Treg (FoxP3+CD25+, surface CD152+, intracellular CD152+, FoxP3+CD127, CD25+CD127, FoxP3+ICOS+, FoxP3+CD154+; and FoxP3+CD274+) was determined by multicolor flow-cytometry. A control group consisted of 20 healthy donors matched for sex and age with the examined patients.Results and discussion.In the patients included in the study, the median [25th; 75th percentiles] DAS28 was 5.01 [4.2; 5.8]; high, moderate, and low activity showed 22 (48.9%), 20 (44.4%), and 3 (6.7%) patients, respectively. The patients with early RA had a lower percentage of FoxP3+CD25+ cells and a lower percentage and absolute count of FoxP3+ICOS+, FoxP3+CD154+, and FoxP3+CD274+ T cells than the healthy donors (p<0.05 in all cases). There was a negative correlation of the percentage of FoxP3+CD25+ cells with C-reactive protein (CRP) (r = -0.4), that of intracellular CD152+ with DAS28 (r = -0.35), erythrocyte sedimentation rate (ESR) (r = -0.46), and CRP (r=-0.54); that of FoxP3+CD127 with CRP (r = -0.42); that of CD25+CD127 with DAS28 (r = -0.38), Simplified Disease Activity Index (r = -0.41), Clinical Disease Activity Index (r = -0.36), ESR (r = -0.39), and CRP (r = -0.47) (p < 0.05 in all cases).Conclusion.The findings suggest that the functional activity of Treg is impaired in early RA, which has an impact on the activity of the inflammatory process.
LATE DIAGNOSIS OF UVEITIS IN A GIRL WITH BEHСET'S DISEASE: DEMONSTRATION OF A CLINICAL CASE
Authors: Alekberova Z. S. , Denisova E. A. , Davydova G. A. , Khatagova Z. R. , Ryabina M. V. 
Published: September 2019

Behсet's disease (BD) is systemic vasculitis with multiorgan failure. According to the 1990 International Study Group for Behсet's disease (ISGBD) criteria, the main manifestations of the disease include recurrent mouth and genital ulcers; skin and eye lesions. Inflammatory diseases of the eye are diagnosed in 50–70% of patients with BD. Our described case illustrates the late diagnosis of BD in a 13-year-old girl, which led to severe eye disease (significantly decreased visual acuity of the left eye) 2 years after disease onset. The lesion of ocular posterior segments is the pathognomonic sign of BD. This symptom concurrent with other major manifestations of BD (skin and genital lesions) and the ethnicity of the patient (a resident of Dagestan, the region through which there was the Great Silk Road) should have promoted the earlier diagnosis of the disease.
Valency-based molecular descriptors of Bakelite network BNmn$B\text N_{m}^{n}$
Authors: Ahmad Maqsood , Javaid Muhammad , Saeed Muhammad , Jung Chahn Yong 
Published: September 2019

AbstractBakelite network $BN_{m}^{n}$is a molecular graph of bakelite, a pioneering and revolutionary synthetic polymer (Thermosetting Plastic) and regarded as the material of a thousand uses. In this paper, we aim to compute various degree-based topological indices of a molecular graph of bakelite network $BN_{m}^{n}$. These molecular descriptors play a fundamental role in QSPR/QSAR studies in describing the chemical and physical properties of Bakelite network $BN_{m}^{n}$. We computed atom-bond connectivity ABC its fourth version ABC4 geometric arithmetic GA its fifth version GA5 Narumi-Katayama, sum-connectivity and Sanskruti indices, first, second, modified and augmented Zagreb indices, inverse and general Randic’ indices, symmetric division, harmonic and inverse sum indices of $BN_{m}^{n}$.
Inoculation against Populism: Media Competence Education and Political Autonomy
Authors: Podschwadek Frodo 
Published: September 2019

Abstract
This paper offers an analysis of the relation between political populism and mass media, and how this relation becomes problematic for democratic societies. It focuses on the fact that mass media, due to their purpose and infrastructure, can unintentionally reinforce populist messages. Research findings from communication science and political psychology are used to illustrate how, for example, a combination of mass media agenda setting and motivated reasoning can influence citizens’ political decisions and impair their political autonomy. This poses a particular normative challenge for modern democracies: how to counter these populism-supporting effects within the constraints of democratic legitimacy? After showing how severely limited legal measures to curb populist media effects would be, the paper argues in favour of media competence education as a way of providing future citizens with an epistemic toolkit to navigate the media environment and strengthen their political autonomy.
Head repositioning accuracy is influenced by experimental neck pain in those most accurate but not when adding a cognitive task
Authors: Christensen Steffan Wittrup McPhee , Peolsson Anneli , Agger Simone May , Svindt Mikkel , Graven-Nielsen Thomas , Hirata Rogerio Pessoto 
Published: September 2019

Abstract

Background and aims
Neck pain can impair perception of cervical movement, but how this is affected by attention is unknown. In this study, the effects of experimental neck pain on head repositioning accuracy during standardized head movements were investigated.

Methods
Experimental neck pain was induced by injecting hypertonic saline into the right splenius capitis muscle in 28 healthy participants (12 women). Isotonic saline was used as control. Participants were blindfolded while performing standardized head movements from neutral (start) to either right-rotation, left-rotation, flexion or extension, then back to neutral (end). Movements were triplicated for each direction, separated by 5-s, and performed with or without a cognitive task at baseline, immediately after the injection, and 5-min after pain disappeared. Repositioning accuracy was assessed by 3-dimensional recordings of head movement and defined as the difference between start and end position. Participants were grouped into most/least accurate based on a median split of head repositioning accuracy for each movement direction at baseline without the cognitive task.

Results
The most accurate group got less accurate following hypertonic injection during right-rotation without a cognitive task, compared with the least accurate group and the isotonic condition (p < 0.01). No group difference was found when testing head repositioning accuracy while the participants where distracted by the cognitive task.

Conclusions
Experimental neck pain alters head repositioning accuracy in healthy participants, but only in those who are most accurate at baseline. Interestingly, this impairment was no longer present when a cognitive task was added to the head repositioning accuracy test.

Implications
The results adds to our understanding of what factor may influence the head repositioning accuracy test when used in clinical practice and thereby how the results should be interpreted.
A note on multilevel Toeplitz matrices
Authors: Cao Lei , Koyuncu Selcuk 
Published: September 2019

Abstract
Chien, Liu, Nakazato and Tam proved that all n × n classical Toeplitz matrices (one-level Toeplitz matrices) are unitarily similar to complex symmetric matrices via two types of unitary matrices and the type of the unitary matrices only depends on the parity of n. In this paper we extend their result to multilevel Toeplitz matrices that any multilevel Toeplitz matrix is unitarily similar to a complex symmetric matrix. We provide a method to construct the unitary matrices that uniformly turn any multilevel Toeplitz matrix to a complex symmetric matrix by taking tensor products of these two types of unitary matrices for one-level Toeplitz matrices according to the parity of each level of the multilevel Toeplitz matrices. In addition, we introduce a class of complex symmetric matrices that are unitarily similar to some p-level Toeplitz matrices.
Depression, Anxiety, and Emergency Department Use for Asthma
Authors: Bardach Naomi S. , Neel Caroline , Kleinman Lawrence C. , McCulloch Charles E. , Thombley Robert , Zima Bonnie T. , Grupp-Phelan Jacqueline , Coker Tumaini R. , Cabana Michael D. 
Published: September 2019

BACKGROUND AND OBJECTIVES:
Asthma is responsible for ∼1.7 million emergency department (ED) visits annually in the United States. Studies in adults have shown that anxiety and depression are associated with increased asthma-related ED use. Our objective was to assess this association in pediatric patients with asthma.

METHODS:
We identified patients aged 6 to 21 years with asthma in the Massachusetts All-Payer Claims Database for 2014 to 2015 using International Classification of Diseases, Ninth and 10th Revision codes. We examined the association between the presence of anxiety, depression, or comorbid anxiety and depression and the rate of asthma-related ED visits per 100 child-years using bivariate and multivariable analyses with negative binomial regression.

RESULTS:
Of 65 342 patients with asthma, 24.7% had a diagnosis of anxiety, depression, or both (11.2% anxiety only, 5.8% depression only, and 7.7% both). The overall rate of asthma-related ED use was 17.1 ED visits per 100 child-years (95% confidence interval [CI]: 16.7–17.5). Controlling for age, sex, insurance type, and other chronic illness, patients with anxiety had a rate of 18.9 (95% CI: 17.0–20.8) ED visits per 100 child-years, patients with depression had a rate of 21.7 (95% CI: 18.3–25.0), and patients with both depression and anxiety had a rate of 27.6 (95% CI: 24.8–30.3). These rates were higher than those of patients who had no diagnosis of anxiety or depression (15.5 visits per 100 child-years; 95% CI: 14.5–16.4; P &lt; .001).

CONCLUSIONS:
Children with asthma and anxiety or depression alone, or comorbid anxiety and depression, have higher rates of asthma-related ED use compared with those without either diagnosis.
Sex-wise changes in haematological and biochemical parameters before and after exchange transfusion in neonatal hyperbilirubinemia
Authors: Joshi Ishan , Sharma Amit 
Published: September 2019

Background: Exchange transfusion (ET) is required in hyperbilirubinemic hospitalized neonates.Methods: The study center at SMS and associated hospitals. The blood bank is licensed and fully equipped. Fall in serum bilirubin minimum of 40 cases was required as the sample size of the present study.Results: The Sex ratio in the neonates undergoing Exchange transfusion was 65% (26) Males and 35% (14) females. The mean values of Hb (g/dl), Hematocrit and Direct bilirubin (mg/dl) of male and female before and after exchange transfusion, were non-significant.Conclusion: Exchange transfusion was required more commonly in male neonates. The mean values of change in Hb (g/dl), Hematocrit and Direct bilirubin (mg/dl) of males and females before and after exchange transfusion, were non-significant. The mean values of change in Indirect bilirubin (mg/dl) in both males and females before and after exchange transfusion was highly significant. The mean values of change in Total bilirubin (mg/dl) in males and in females were significant.
A comparative study on the effectiveness of bupivacaine and ropivacaine for supraclavicular block
Authors: Sejpal Nekee Navin , Bande B. D. , Sejpal Kapil Navin , Rajdeo Ravi Nirmalkumar 
Published: September 2019

Background: Bupivacaine and Ropivacaine have been extensively studied &their properties with respect to onset, duration and quality of block. This study aims to detect whether addition of clonidine to both of them changes their properties. This study also aims to use lower than usual dosages for both the local anesthetics to prevent adverse effects of local anesthetics.Methods: After obtaining ethical approval, the study was carried out on patients undergoing elective upper limb surgeries. They were randomly divided into two Groups: Group B and Group R. The onset and duration of sensory and motor blockade and other parameters were assessed.Results: The onset of blockade, both sensory & motor was earlier in Ropivacaine as compared to Bupivacaine group. Mean duration of blockade, both sensory & motor, was more in the Bupivacaine group. Conclusions: Addition of Clonidine enabled the use of low concentrations (0.25%) of both the anesthetics. Also, Ropivacaine (0.25%) has faster onset of sensory and motor blockade, shorter duration of action and less motor blockade compared to Bupivacaine.
Pattern of tuberculosis among tribal population of Central India with special reference to cartridge based nucleic acid amplification test as diagnostic tool: a descriptive study at tertiary care hospital
Authors: Gajbhiye Swati B. , Madkey Madhavi V. , Gedam Dilip S. 
Published: September 2019

Background: Tuberculosis (TB) kills close to half a million Indians every year. Lack of reliable rapid diagnostic techniques for TB hampers timely diagnosis and leads to continued disease transmission, causing significant morbidity and mortality. The potential of newly recommended CBNAAT in TB and MDR-TB detection has been underutilized in our area due to lack of awareness regarding the same. Hence we utilized this rapid, logistically simplified test to study the pattern of tuberculosis among tribal population of Central India.Methods: Descriptive study of suspected TB patients in tertiary care centre from March 2016 to March 2019. Appropriate specimens from suspected TB patients were collected and subjected to CBNAAT and AFB smear to study the pattern of TB and Rifampicin- Resistant(RR) TB in our area.Results: CBNAAT detected overall 27% MTB cases; 27.72 % Pulmonary-TB cases as against smear positivity rate of 20.73% whereas 12.74% Extra-pulmonary-TB (EPTB) cases as against smear positivity rate of 1.59%.Overall 94.91% were RiF Sensitive( RS-TB) and 4.58% were RR-TB. Of the 57 (4.16%) HIV-TB coinfected cases; 96.49% were RS-TB and 5.26% were RR-TB. Co-infected patients have high incidence of EPTB(21.05%) involvement with RR-TB 3.50%. Among EPTB cases; lymph node aspirate and pus provided highest CBNAAT positive cases and almost 90.62% EPTB specimens were RS-TB .Conclusions: Availability of new diagnostic services has increased early identification of TB and RR-TB. Awareness among physicians regarding diagnostic utility of CBNAAT should be further increased as early identification of possible MDR cases is key to reducing community transmission and treatment initiation, particularly in high-burden, resource-limited settings.
Study on the Eﬀect of Material Absorption of Photonic Crystals on Transverse Magnetic Wave Band
Authors: Hao Shi 
Published: September 2019

<p align="justify">Photonic crystals are a major discovery in physics and have an important inﬂuence on our present life. The biggest feature of the photonic crystals is that they have bandgap which can block photons of a certain frequency, thus affecting the photon movement. This effect resembles the inﬂuence of the semiconductor body on electrons. Therefore, research and discovery of the photonic crystal have a broad prospect and people have large expectation on the photonic crystal. The emergence of photonic crystals makes it possible for the miniaturization and integration of some aspects of information technology. Their structure studies enable us to determines their characteristics, thus the discovery of the photonic crystal structure and function will lay the foundation for the study of its application. In this paper, the study focuses on the research of material absorption of photonic crystal on Transverse Magnetic (TM) wave band. Firstly, the basic knowledge and principle of photonic crystal are introduced. Then, the research is carried out to study the effect of characteristic matrix method on photon crystal TM energy wave. </p><p align="justify"> </p>
System-based DNA microarray analyses of different gene expression profile in spontaneously hypertensive rats treated with Songling Xuemaikang Capsule reveals underlying causal mechanisms.
Authors: Liu Li-tao , Yan Cui-qi , Tang Qiao-xin , Zhao Man-xi , Teng Chuan-zhen , Ye Liang , Ke Xiao 
Published: September 2019

Abstract
Background: Hypertension is considered the major risk factor for human health in the world. Songling Xuemaikang Capsule (SXC) is clinically used as a medicine for the prevention and treatment of cardiovascular and cerebrovascular diseases such as hypertension and hyperlipidemia. However, the underlying mechanisms have yet to be fully identified. Methods: Valsartan, as a positive control drug, high- and low-dose of SXC were orally administration with for 28 days to investigate the anti-hypertensive effect of SXC in spontaneously hypertensive rats (SHRs). The serum levels of aldosterone and Angiotensin II (Ang II) were detected. The gene expression profiling was performed in the thoracic aorta of SHRs using the Whole Rat Genome Oligo nucleotide Microarray. The integrated causal network analysis was performed to understand the mechanism of antihypertensive effect of SXC. Results: The results shown that the systolic and diastolic blood pressure were significant decreased in SXC low-dosage group and high-dosage group compared with the control group respectively. SXC low and high-dosage treatment decreased serum aldosterone levels significantly but increased serum Ang II compared with the control group respectively. Causal network analysis shown that treatment with SXC reversing the vascular remodeling process, inhibiting vascular inflammation and atherosclerosis, reversing endothelial cells dysfunction and likely reducing peripheral vascular resistance by down-regulated processes related to vascular remodeling, dyslipidemia, the complement system, leukocyte rolling, and endothelial dysfunction. In addition, SXC treatment may also activate fibrinolysis and regulate lipid and glucose metabolism. Conclusions: Those obtained data could help our understanding and potential utilization of SXC in the treatment or prevention of hypertension。
Polygonatum sibiricum polysaccharide affects growth performance and immune response in cyclophosphamide-induced immunosuppressed chickens
Authors: Xu Dan , Zhao Jin , Ran Chonglin , Xu Lu , Ren Shaojun , Huang Yuanlin , Tang Ziting , Lin Juchun , Fu Hualin , Zhang Wei , He Changliang , Zhao Xiaoling , Shu Gang 
Published: September 2019

Abstract
Background: This study aims to identify the effects of dietary Polygonatum sibiricum polysaccharide (PP) on growth performance and blood parameters in immunosuppressed chickens induced by cyclophosphamide (CY).
Results: The results showed that PP enhanced the growth performance and immune response in chickens treated with cyclophosphamide characterized by increasing relative weight of thymus, total antioxidant capacity (T-AOC), superoxidase dismutase (SOD), albumin (ALB), immunoglobulin M (IgM), and antibody titers of Newcastle disease (ND) and avian influenza (H9), and decreasing feed conversion ratio (FCR) and malondialdehyde (MDA) level.
Conclusions: PP enhanced chickens’ growth performance via improving antioxidant ability and alleviating CY-induced immunological stress.