bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrolyzation of duck meat protein using Bacillus cereus TD5B protease, pepsin, trypsin and their potency as an angiotensin converting enzyme inhibitor
Authors: Winarti A. , Rahmawati F. , Fitriyanto N. A. , Jamhari J. , Erwanto Y. 
Published: September 2019

This study was aimed to explore their potency of protein-bioactive of native ducks-meat after enzymatic hydrolysis by Bacillus-cereus TD5B-protease, Pepsin, and Trypsin as an angiotensin-converting enzyme (ACE) inhibitor. The samples: ducks-meats from 10 months age of male Mojosari and Magelang-Duck. The experiments: individually hydrolysis of meat-protein using protease-enzyme (0.1 % w/w) from Bacillus-cereus TD5B, Pepsin, or Trypsin. The observed parameters: protein concentration, protein molecular weight, ACE-inhibitor activity, and IC-value (IC50). Data of protein concentration were statistically analyzed using T-Test, while data of SDS-PAGE and ACE-inhibiting activity were analyzed descriptively. The results showed that soluble protein concentration increased due to the hydrolysis process, from 0.826±0.108 mg/mL to 1.050±0.197 mg/mL (Microbial-protease), 2.122±0.141 mg/mL (pepsin), 1.641±0.071 mg/mL (trypsin) for Mojosari-duck and 0.642±0.038 mg/mL to 1.171±0.534 mg/mL(Microbial-protease), 2.100±0.376 mg/mL(pepsin), 1.725±0.092 mg/mL(trypsin) for Magelang-duck. The SDS-PAGE pattern showed that there was a decrease of molecular weight of duck-meats due to the hydrolysis process, from the range of 196.53-43.88 kDa to the range of 71.35-10.12 kDa. Duck-meat protein hydrolysate had ACE-inhibiting activity 71.7%(Mojosari-Microbial-Protease) IC50 54μg/mL, 57%(Mojosari-Pepsin) IC50 151μg/mL, 75.8%(Mojosari-Trypsin) IC50 51μg/mL and 52.8%(Magelang-Microbial-Protease) IC50 83μg/mL, 78,5%(Magelang-Pepsin) IC50 85μg/mL, 83.9%(Magelang-Trypsin) IC50 22μg/mL. In conclusion, hydrolysate of Magelang duck-meat used Trypsin had better potency as an ACE-inhibitor.
Production, quality and livestock carrying capacity of Panicum maximum and Sesbania grandiflora at saline soil with different manure application
Authors: Kusmiyati F. , Pangestu E. , Surahmanto S. , Purbajanti E.D. , Herwibawa B. 
Published: September 2019

The objective of this study was to evaluate the effect of manure at saline soil on forage production, quality and livestock carrying capacity of P. maximum and S. grandiflora. The research was conducted on moderately saline soil at Rembang Regency, Central Java Province, Indonesia.Randomized complete block design was used as design experiment. The treatments were different dosage of manure as organic amendment (0, 10 and 20 tonnes/ha). Forage crops were P. maximum and S. grandiflora that planted monoculture or mixed-cropping. Parameters measured were dry matter (DM) production, ash, crude protein, crude fibre, ether extract, total digestible nutrients. P. maximum was cut eight times, S. grandiflora was cut six times during one year. The result showed that the highest total dry matter production of mixed cropping P. maximum and S. grandiflora was available at moderately saline soil with application 20 ton/ha manure. Total production of dry matter, crude protein and total digestible nutrient available at application 20 ton/ha manure were 29131 kg/ha/year; 3722 kg/ha/year and 17718 kg/ha/year, respectively. Carrying capacity based on dry matter, crude protein and total digestible nutrients were 10.8 AU/ha/year; 13.6 AU/ha/year and 11.3 AU/ha/year, respectively. In conclusion, application of 20 ton/ha manure at saline soil increased production, crude protein and carrying capacity.
YÜKSELEN PİYASALARDA ULUSLARARASI FİNANSAL YAYILIMLAR
Authors: KUBİLAY Mustafa Murat , SÖYLEMEZ Arif Orçun 
Published: September 2019

Bu çalışmada
önde gelen 18 yükselen piyasa ekonomisi ile seçilmiş bir grup ekonomi (yükselen
ya da gelişmiş) arasındaki finansal etkileşimleri test etmek amacıyla&nbsp; ülkelerin döviz, tahvil ve hisse senedi
piyasaları arasındaki getiri ve risk yayılımlarına bakılmıştır. Çalışmada
2010-2016 arasını kapsayan bir veriseti kullanılarak VAR ve çok değişkenli
GARCH BEKK modelleri ile tahminlerde bulunulmuştur. Sonuç olarak gelişmiş
piyasaların yükselen piyasalara kıyasla her üç piyasada daha fazla getiri
yayılımına neden oldukları tespit edilmiştir. İkinci olarak en yüksek finansal
gelişmişlik düzeyine sahip olan yükselen piyasa ülkelerinde getiri yayılımları
daha belirgindir. Üçüncü olarak getiri yayılımının en sık rastlandığı piyasa
tahvil; oynaklık yayılımının en çok bulunduğu ise hisse senedi piyasası
olmuştur. Finansal çeşitlendirme amacıyla farklı piyasalara yapılan
yatırımların sözkonusu yayılımlardan ötürü yükselen piyasalarda sınırlı başarı
sağlayacağı sonucuna varılmıştır. Bu çalışma uluslararası yatırımcıların getiri
ve risk analizlerine katkı sağlayacaktır.&nbsp;
Legionella infection in pregnancy: imitator of HELLP syndrome, presenting as acute respiratory failure and septic shock
Authors: Gulersen Moti , Bornstein Eran 
Published: September 2019

Abstract

Background
Legionnaires’ disease in pregnancy may cause severe maternal complications. Hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome is a disorder associated with significant maternal and fetal morbidity and mortality. Several medical conditions have been described as imitators of this syndrome, presenting with similar laboratory abnormalities.

Case presentation
A healthy, multiparous woman presented at 26 weeks’ gestation with fever, headache and general malaise, rapidly progressing to septic shock and respiratory collapse. Laboratory evaluation revealed similar abnormalities to those seen with HELLP syndrome. Emergent cesarean delivery was performed for worsening maternal and fetal conditions. Following delivery, infection with Legionella was diagnosed on urinary antigen testing. Supportive care was administered in the intensive care unit.

Conclusion
Legionnaires’ disease should be considered in gravidas presenting with rapidly deteriorating respiratory status, septic shock and laboratory abnormalities mimicking HELLP syndrome.
Treating Rapid Responses as Incorrect for Non-Timed Formative Tests
Authors: Wright Daniel B. 
Published: September 2019

AbstractWhen students respond rapidly to an item during an assessment, it suggests that they may have guessed. Guessing adds error to ability estimates. Treating rapid responses as incorrect answers increases the accuracy of ability estimates for timed high-stakes summative tests like the ACT. There are fewer reasons to guess rapidly in non-timed formative tests, like those used as part of many personalized learning systems. Data from approximately 75 thousand formative assessments, from 777 students at two northern California charter high schools, were analyzed. The accuracy of ability estimates is only slightly improved by treating responses made in less than five seconds as incorrect responses. Simulations show that the advantage is related to: whether guesses are made rapidly, the amount of time required for thoughtful responses, the number of response alternatives, and the preponderance of guessing. An R function is presented to implement this procedure. Consequences of using this procedure are discussed.
Exploration of Heterogeneous Treatment Effects via Concave Fusion
Authors: Ma Shujie , Huang Jian , Zhang Zhiwei , Liu Mingming 
Published: September 2019

Abstract
Understanding treatment heterogeneity is essential to the development of precision medicine, which seeks to tailor medical treatments to subgroups of patients with similar characteristics. One of the challenges of achieving this goal is that we usually do not have a priori knowledge of the grouping information of patients with respect to treatment effect. To address this problem, we consider a heterogeneous regression model which allows the coefficients for treatment variables to be subject-dependent with unknown grouping information. We develop a concave fusion penalized method for estimating the grouping structure and the subgroup-specific treatment effects, and derive an alternating direction method of multipliers algorithm for its implementation. We also study the theoretical properties of the proposed method and show that under suitable conditions there exists a local minimizer that equals the oracle least squares estimator based on a priori knowledge of the true grouping information with high probability. This provides theoretical support for making statistical inference about the subgroup-specific treatment effects using the proposed method. The proposed method is illustrated in simulation studies and illustrated with real data from an AIDS Clinical Trials Group Study.
Can there be a Finite Interpretation of the Kantian Sublime?
Authors: Golob Sacha 
Published: September 2019

Abstract
Kant’s account of the sublime makes frequent appeals to infinity, appeals which have been extensively criticised by commentators such as Budd and Crowther. This paper examines the costs and benefits of reconstructing the account in finitist terms. On the one hand, drawing ona detailed comparison of the first and third Critiques, I argue that the underlying logic of Kant’s position is essentially finitist. I defend the approach against longstanding objections, as well as addressing recent infinitist work by Moore and Smith. On the other hand, however, I argue that finitism faces distinctive problems of its own: whilst the resultant theory is a coherent and interesting one, it is unclear in what sense it remains an analysis of the sublime. I illustrate the worry by juxtaposing the finitist reading with analytical cubism.
Ultra-compact integrated graphene plasmonic photodetector with bandwidth above 110 GHz
Authors: Ding Yunhong , Cheng Zhao , Zhu Xiaolong , Yvind Kresten , Dong Jianji , Galili Michael , Hu Hao , Mortensen N. Asger , Xiao Sanshui , Oxenløwe Leif Katsuo 
Published: September 2019

Abstract
Graphene-based photodetectors, taking advantage of the high carrier mobility and broadband absorption in graphene, have recently seen rapid development. However, their performance with respect to responsivity and bandwidth is still limited by the weak light-graphene interaction and large resistance-capacitance product. Here, we demonstrate a waveguide-coupled integrated graphene plasmonic photodetector on a silicon-on-insulator platform. Benefiting from plasmon-enhanced graphene-light interaction and subwavelength confinement of the optical energy, a small-footprint graphene-plasmonic photodetector is achieved working at the telecommunication window, with a large a bandwidth beyond 110 GHz and a high intrinsic responsivity of 360 mA/W. Attributed to the unique electronic band structure of graphene and its ultra-broadband absorption, operational wavelength range extending beyond mid-infrared, and possibly further, can be anticipated. Our results show that the combination of graphene with plasmonic devices has great potential to realize ultra-compact, high-speed optoelectronic devices for graphene-based optical interconnects.
Crystal structure of (cyclohexane-1,4-diammonium) 4-[(4-carboxylatophenyl)disulfanyl]benzoate dimethylsulphoxide hydrate (1/1/1/1), [C6H16N2]2+[C14H8O4S2]2−⋅C2H6OS⋅H2O
Authors: Tan Sang Loon , Tiekink Edward R. T. 
Published: September 2019

Abstract
C22H32N2O6S3, triclinic, P1̄ (no. 2), a = 6.1543(1) Å, b = 14.4991(2) Å, c = 15.3859(3) Å, α = 64.545(2)°, β = 81.828(1)°, γ = 89.505(1)°, V = 1224.93(4) Å3, Z = 2, R
gt(F) = 0.0290, wR
ref(F
2) = 0.0787, T = 100 K.
Prion Evolvability and the Hazard of Atypical Scrapie in Small Ruminants
Authors: Adams David B. 
Published: September 2019

AbstractObservations on strain behaviour and direct demonstrations of natural selection establish that the scrapie agent and prions in general are able to evolve. Accordingly, it is conceivable that atypical non-contagious scrapie in sheep and goats can transform to classical contagious scrapie under particular circumstances. In consequence, atypical scrapie can be regarded as a latent hazard that warrants comprehensive risk assessment and biosecurity preparedness planning. Evidence for this proposition comes from differences in the expression of atypical and classical scrapie that may make scrapie contagious, historical records of scrapie in Western Europe, and contemporary accounts of the epidemiology of atypical scrapie. Biosecurity preparedness can be based on current knowledge of pathophysiology and epidemiology and can be built around a three-stage model for the endogenous emergence of a propagating epidemic of scrapie. The first stage concerns the occurrence of atypical scrapie. The second stage concerns the acquisition of communicability in prion populations provided by atypical scrapie and the third stage concerns circumstances allowing disease transmission and the initiation of a propagating epidemic. The range of component causes envisaged for possible outbreaks of endogenous classical scrapie is broad. However, exposure of sheep and goats to cyanobacterial toxins qualifies for special attention.
Reactivity of fly ashes milled in different milling devices
Authors: Chu Yong-Sik , Davaabal Batmunkh , Kim Dae-Sung , Seo Sung-Kwan , Kim Yoo , Ruescher Claus , Temuujin Jadambaa 
Published: September 2019

Abstract
The effect of two different milling devices, namely attrition mill versus vibration mill, on the reactivity of fly ash was studied. High calcium fly ash from 4th Thermal power station of Ulaanbaatar (Mongolia) was used for the experiments. The raw and processed samples were characterized by XRD, SEM, Particle size distribution, BET, Blaine surface area and density measurements. The efficiency of 1 hour milling was evaluated with the Blaine surface area set to be more than 5000 cm2/g. The physical and chemical properties of the attrition milled fly ash changed not much compared to the vibration milled samples. For example the d50 particle size became reduced from 29 µm to 6 µm by attrition milling and in vibration milled fly ash it was reduced to 7 µm. The density increased from 2.44 g/cm3 of raw fly ash to 2.84 g/cm3 and 2.79 g/cm3 in attrition and vibration milled samples, respectively. Mechanical milling revealed not only a particle size reduction but also the formation of a denser microstructure. As a result the vibration milled fly ash showed a weaker interaction with the alkaline solution (8 M NaOH used here) compared to the attrition milled fly ash. Consequently, compressive strength of the binder prepared using the attrition milled fly ash was higher, 61 MPa, while for vibration milled fly ash it was 49 MPa. For comparison unmilled fly ash, it was 21 MPa.
Genetic Dissection Reveals the Role of Ash1 Domains in Counteracting Polycomb Repression
Authors: Dorafshan Eshagh , Kahn Tatyana G , Glotov Alexander , Savitsky Mikhail , Schwartz Yuri B 
Published: September 2019

AbstractAntagonistic functions of Polycomb and Trithorax proteins are essential for proper development of all metazoans. While the Polycomb proteins maintain the repressed state of many key developmental genes, the Trithorax proteins ensure that these genes stay active in cells where they have to be expressed. Ash1 is the Trithorax protein that was proposed to counteract Polycomb repression by methylating lysine 36 of histone H3. However, it was recently shown that genetic replacement of Drosophila histone H3 with the variant that carried Arginine instead of Lysine at position 36 did not impair the ability of Ash1 to counteract Polycomb repression. This argues that Ash1 counteracts Polycomb repression by methylating yet unknown substrate(s) and that it is time to look beyond Ash1 methyltransferase SET domain, at other evolutionary conserved parts of the protein that received little attention. Here we used Drosophila genetics to demonstrate that Ash1 requires each of the BAH, PHD and SET domains to counteract Polycomb repression, while AT hooks are dispensable. Our findings argue that, in vivo, Ash1 acts as a multimer. Thereby it can combine the input of the SET domain and PHD-BAH cassette residing in different peptides. Finally, using new loss of function alleles, we show that zygotic Ash1 is required to prevent erroneous repression of homeotic genes of the bithorax complex in the embryo.
Helium Isotope Ratios in Spring Waters of the Tunka–Oka–Sayan Rift (East Sayan Area): Correlation with Heat Flow
Authors: Rychkova K.M. , Ayunova O.D. 
Published: September 2019

Abstract
—Studies of helium isotope ratios in groundwaters discharging as springs within the Tunka–Oka–Sayan rift in the East Sayan area reveal an anomaly extending for 350 km along the East Sayan fault on the extension of the Tunka anomaly in the southwestern flank of the Baikal rift system. The calculated heat flow values (qR) agree with the measured ones (qT), and the heat flow anomalies correlate with those in the 3He/4He ratios throughout the Oka–Sayan and Bilin–Busiyn-Gol rifts. The correlation of the geophysical and geochemical parameters confirms that both are controlled by heat and mass transfer. Both mantle helium and heat apparently originate from a mantle plume beneath the South Baikal volcanic province (SBVP). The concordant 3He/4He and heat flow patterns in the Oka–Sayan fault record ongoing rifting and magmatism along the East Sayan Fault zone. The helium isotope and heat flow anomalies are consistent with the presence of low-velocity zones in the upper 200 km beneath the southwestern Baikal rift zone as far as the southern edge of the Siberian craton, which are detectable in seismic tomography images. Magmatism in the extreme southwest of the Baikal rift zone was maintained by active tectonic movements in the Pliocene and by the activity of the SBVP mantle plume. The obtained helium isotope data and high heat flow values indicate that rifting and magmatism propagate northwestward along the East Sayan Fault zone. This pattern fits the geothermal model for continental rifts implying that magmatic activity in the western end of BRS has been controlled by lithospheric deformation. The geothermal model for the Baikal–Mongolia region covers the area northwest of the system of three rift basins along the East Sayan faults.
Dentists’ perspectives on the reconstruction possibilities of a non-vital tooth
Authors: Chisnoiu Andrea , Picos Alina , Lascu Liana , Negucioiu Marius , Chisnoiu Radu , Kui Andreea 
Published: September 2019

Background and aims. The decision-making process when restoring a non-vital tooth is influenced by multiple factors. This study aimed to survey the dentists’ preferences regarding cast post-and-core and fiber post techniques for the reconstruction of non-vital teeth and to identify a correlation between reconstruction technique and practitioners characteristics, or dental characteristics.
Methods. The survey instrument was a questionnaire, which included a general part with questions regarding the practitioner’s profile (gender, age, years of experience, pattern and location of practice, etc.) and the dental characteristics (anterior or posterior position of the tooth on the arch, the amount of dental remaining tissues, etc.). and a technical part, containing more specific questions regarding the manufacture and performance of root-coronal reconstructions.
Results. Among the surveyed practitioners (n=35), 69.7% use more often cast post-and-core reconstructions (CPR) while 30.3% choose fiber post reconstructions (FPR). No difference in the reconstruction type was observed regarding patient’s age (p=0.23) or gender (p=0.092). The para-function criterion was considered important by 8.23% of the participants. When deciding the type of the root-coronal reconstruction depending on the remaining dentine walls, CPRs are significantly more frequently used in posterior areas (p=0.043) or when para-functional habits exist (p=0.022).
Conclusion. Cast post-and-core represent the most frequently used type of reconstruction for non-vital teeth. Fiber post reconstructions are indicated in the aesthetic zone and when the amount of healthy remaining dental structure is higher.
Character Building Through Reinforcement of Islamic Learning
Authors: Nurbaiti Nurbaiti , Suparta Mundzier , Syukur Taufik Abdillah 
Published: September 2019

AbstractThis research explores the effects of teacher’s pedagogical competence and student’s achievement to student’s character building. The research method used is mixed method. Data collected by test, questionnaire, interview and observation. Data analyzed by bivariate correlation and Triangulation. The result of this study proved that character building through reinforcement of Islamic learning is effected by the teacher’s pedagogical competence and student’s achievement.AbstrakTujuan dari penelitian ini adalah untuk mengetahui bagaimana kompetensi pedagogik guru dan prestasi belajar siswa mempengaruhi pembentukan karakter siswa. Metode penelitian yang digunakan adalah metode penelitian campuran (Mixed Method). Pengumpulan data dilakukan melalui tes, angket, wawancara dan pengamatan (observasi). Analisis data dilakukan dengan korelasi ganda dan triangulasi. Dari hasil penelitian diperoleh hasil bahwa pendidikan karakter siswa dipengaruhi oleh kompetensi pedagogik guru dan prestasi belajar siswa pada Mata Pelajaran Pendidikan Agama Islam. How to Cite : Nurbaiti, Suparta, M., Syukur, T. A. (2019). Character Building Through Reinforcement of Islamic Learning. TARBIYA: Journal of Education in Muslim Society, 6(1), 36-45. doi:10.15408/tjems.v6i1.10984.
Screening Children for Social Determinants of Health: A Systematic Review
Authors: Sokol Rebeccah , Austin Anna , Chandler Caroline , Byrum Elizabeth , Bousquette Jessica , Lancaster Christiana , Doss Ginna , Dotson Andrea , Urbaeva Venera , Singichetti Bhavna , Brevard Kanisha , Wright Sarah Towner , Lanier Paul , Shanahan Meghan 
Published: September 2019

CONTEXT:
Screening children for social determinants of health (SDOHs) has gained attention in recent years, but there is a deficit in understanding the present state of the science.

OBJECTIVE:
To systematically review SDOH screening tools used with children, examine their psychometric properties, and evaluate how they detect early indicators of risk and inform care.

DATA SOURCES:
Comprehensive electronic search of PubMed, Cumulative Index to Nursing and Allied Health Literature, Embase, Cochrane Central Register of Controlled Trials, and Web of Science Core Collection.

STUDY SELECTION:
Studies in which a tool that screened children for multiple SDOHs (defined according to Healthy People 2020) was developed, tested, and/or employed.

DATA EXTRACTION:
Extraction domains included study characteristics, screening tool characteristics, SDOHs screened, and follow-up procedures.

RESULTS:
The search returned 6274 studies. We retained 17 studies encompassing 11 screeners. Study samples were diverse with respect to biological sex and race and/or ethnicity. Screening was primarily conducted in clinical settings with a parent or caregiver being the primary informant for all screeners. Psychometric properties were assessed for only 3 screeners. The most common SDOH domains screened included the family context and economic stability. Authors of the majority of studies described referrals and/or interventions that followed screening to address identified SDOHs.

LIMITATIONS:
Following the Healthy People 2020 SDOH definition may have excluded articles that other definitions would have captured.

CONCLUSIONS:
The extent to which SDOH screening accurately assessed a child’s SDOHs was largely unevaluated. Authors of future research should also evaluate if referrals and interventions after the screening effectively address SDOHs and improve child well-being.