bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common pollen and related allergen components in patients with allergic diseases in the Beijing area
Authors: Hou Yi-Bo , Sun Jin-Lu 
Published: November 2024

BackgroundPollen is the most common outdoor allergen that causes allergic rhinitis and asthma, which seriously affects patient quality of life and extensive cross-reactivity occurs between pollen allergens.MethodsThe study enrolled 84 patients with respiratory allergies and at least one pollen allergy who visited the clinic. Specific-IgE was detected via immunoblotting in the sera of patients with positive respiratory allergies to pollen. IgE of the components and cross-reactive carbohydrate determinants (CCD) were evaluated using a fluorescence-encoded microsphere assay.ResultsOur results suggest that Artemisia absinthium, Artemisia vulgaris, Humulus scandens, Amaranthus, Parietaria micrantha allergies are most common in the northern region, and that weed pollen remains the major pollen allergen in the northern region. Among the different age groups, the positive rate of Platanus pollen allergens was significantly higher in patients ≤18 years of age than in those aged &gt;18 years (55.56% vs. 9.17%, χ² = 0.55, p &lt; 0.027). Patients with allergic rhinitis and asthma had an increased positive rate for Betula pollen allergen (20.00% vs. 37.93 χ² = 7.87, p = 0.005) and Platanus pollen allergen (27.27% vs. 51.72%, χ² = 11.05, p = 0.0008) than those with allergic rhinitis alone, although the allergen positivity rate did not significantly differ between sexes. In addition, the positivity of sIgE of allergen components did not reveal a correlation with clinical symptoms and anti-CCD IgE positivity was 1.19% (1/84) among all patients.ConclusionThe study found the distribution characteristics of common pollen allergens in Beijing among patients of different ages and genders and with different allergic diseases, as well as the relationship between pollen allergen components and symptoms. The positivity rate of CCD for respiratory allergic diseases in Beijing was not high as well.
Exploring the shared pathogenic mechanisms of tuberculosis and COVID-19: emphasizing the role of VNN1 in severe COVID-19
Authors: Sun Peng , Wang Yue , Zhou Sijing , Liang Jiahui , Zhang Binbin , Li Pulin , Han Rui , Fei Guanghe , Cao Chao , Wang Ran 
Published: November 2024

BackgroundIn recent years, COVID-19 and tuberculosis have emerged as major infectious diseases, significantly contributing to global mortality as respiratory illnesses. There is increasing evidence of a reciprocal influence between these diseases, exacerbating their incidence, severity, and mortality rates.MethodsThis study involved retrieving COVID-19 and tuberculosis data from the GEO database and identifying common differentially expressed genes. Machine learning techniques, specifically random forest analysis, were applied to pinpoint key genes for diagnosing COVID-19. The Cibersort algorithm was employed to estimate immune cell infiltration in individuals with COVID-19. Additionally, single-cell sequencing was used to study the distribution of VNN1 within immune cells, and molecular docking provided insights into potential drugs targeting these critical prognosis genes.ResultsGMNN, SCD, and FUT7 were identified as robust diagnostic markers for COVID-19 across training and validation datasets. Importantly, VNN1 was associated with the progression of severe COVID-19, showing a strong correlation with clinical indicators and immune cell infiltration. Single-cell sequencing demonstrated a predominant distribution of VNN1 in neutrophils, and molecular docking highlighted potential pharmacological targets for VNN1.ConclusionsThis study enhances our understanding of the shared pathogenic mechanisms underlying tuberculosis and COVID-19, providing essential insights that could improve the diagnosis and treatment of severe COVID-19 cases.
An index-based holistic approach to evaluate flood preparedness: evidence from Bangladesh
Authors: Rahman Md. Mostafizur , Islam Md. Rakibul , Shobuj Ifta Alam , Hossain Md. Tanvir , Ahsan Md. Nasif , Alam Edris , Al Hattawi Khawla Saeed , Islam Md. Kamrul 
Published: November 2024

IntroductionThis study aims to assess individual flood preparedness in the flood-prone Islampur Union of Sunamganj District, Bangladesh, using an index-based Holistic Individual Preparedness Model (HIPM).MethodsA total of 510 respondents participated in a face-to-face field survey, which employed 21 flood preparedness indicators. The key objectives were to evaluate the extent of individual preparedness and its determinants. Statistical methods such as multiple linear regression and Spearman’s rank correlation were used to analyze the relationship between preparedness and various sociodemographic factors.Results and discussionThe results show that 91% of respondents felt insecure during floods and 86% experienced damage to their homes. A significant proportion (87%) rated flood warnings as inadequate, while 84% did not seek refuge in flood shelters. Notably, 54% of respondents demonstrated limited knowledge of flood preparedness measures. Factors like gender, housing type, monthly income, and evaluation of flood warnings were associated with preparedness levels, with females and residents of kacha (unsafe) houses being less prepared. The study underscores the need for targeted campaigns and educational initiatives to improve preparedness, particularly for vulnerable groups.
The association between stress hyperglycemia ratio with mortality in critically ill patients with acute heart failure
Authors: Ge Tingai , Hu Jingjing , Zhou Yidan 
Published: November 2024

BackgroundIt's recognized that stress hyperglycemia ratio (SHR) is considered a significant indicator of poor prognosis in many diseases. However, its role in critically ill patients with acute heart failure (acute HF) remains underexplored.MethodsWe conducted a retrospective cohort study on patients with acute HF included in the Medical Information Mart for Intensive Care IV (MIMIC-IV) version 2.2 database. A restricted cubic spline (RCS) regression analysis was used to explore the relationship between SHR and the risk of all-cause mortality in these patients. Subsequently, a Cox regression model was used to evaluate the relationship between SHR and mortality in acute HF patients.ResultsA total of 1,644 acute HF patients were included in the study and divided into two groups: the low SHR group (SHR &lt; 1.06, N = 823) and the high SHR group (SHR ≥ 1.06, N = 821). In our study, the 30-day, 90-day, 180-day, and 365-day mortality rates for acute HF were 7.0%, 12%, 15%, and 19%, respectively, with higher mortality rates observed in the high SHR group compared to the low SHR group. SHR levels showed a linear relationship with all-cause mortality. Furthermore, SHR as a continuous variable shows a significant positive correlation with 30-day (HR = 2.31, 95% CI: 1.58–3.39), 90-day (HR = 1.81, 95% CI: 1.31–2.52), 180-day (HR = 1.57, 95% CI: 1.16–2.12), and 365-day (HR = 1.41, 95% CI: 1.07–1.85) all-cause mortality. After categorization, high SHR remains associated with increased 30-day (HR = 2.4, 95% CI: 1.59–3.61), 90-day (HR = 1.76, 95% CI: 1.31–2.36), 180-day (HR = 1.51, 95% CI: 1.16–1.95), and 365-day (HR = 1.38, 95% CI: 1.09–1.73) all-cause mortality.ConclusionOur findings indicate that high SHR is an independent predictor of poor short- and long-term prognosis in acute HF patients. Understanding the impact of SHR on mortality in acute HF is crucial as it can assist clinicians in identifying high-risk patients and adjusting treatment strategies accordingly.
Communal and agentic teacher behavior in teacher-child dyads. A new self-report scale based on a circumplex approach
Authors: Kreutzmann Madeleine , Frühauf Madita , Hannover Bettina , Koeppen Karoline 
Published: November 2024

IntroductionThe goal of this study was to develop a self-report scale measuring the teacher’s interpersonal behavior in teacher-child dyads in elementary schools and to provide evidence of the scale’s validity. Using the framework of interpersonal theory, the Questionnaire on Dyadic Interpersonal Teacher Behavior (DITeB) models teacher behavior in an interpersonal circumplex that allows for the simultaneous analysis of teacher behavior along the two orthogonal dimensions of communion (warmth) and agency (guidance, monitoring).MethodsWe analyzed 440 dyadic teacher-child relationships derived from 88 teacher reports. Teachers rated the 20 items (8 scales) of the DITeB to describe their interpersonal behavior towards a child. To test the scale’s structural validity, we conducted confirmatory circumplex structural analyses. To test the scale’s construct validity, we used teachers ‘descriptions of relationship quality (closeness, conflict, dependency), and of their child related emotions (enjoyment, anger, anxiety). In addition, teachers reported on the child’s academic performance (numeric grades), as well as their professional beliefs about heterogeneity and self-efficacy for adaptive teaching, data which were used for further construct validation.ResultsWe obtained empirical support for both structural and construct validity of the DITeB. Teacher interpersonal behavior correlated significantly with perceived relationship quality and emotions: high relationship quality and positive emotions were associated with high communion and low agency, whereas low relationship quality and negative emotions were associated with low communion and high agency, supporting construct validity. Additionally, as child’s academic performance improved, teachers’ agency decreased. Towards different groups of children, teachers’ interpersonal behaviors varied systematically based on their professional beliefs: teachers with strong heterogeneity beliefs tended to be more communal towards low-performing children compared to high-performing children. Moreover, teachers with strong self-efficacy towards adaptive teaching adjusted their agency more flexibly according to children’s performance in school, further supporting the construct validity of our instrument.DiscussionWe discuss how our instrument enriches the spectrum of existing scales on interpersonal teacher behavior. By focusing dyadic specific teacher behavior, the DITeB allows examining the extent to which the teacher adapts their behavior to child characteristics (adaptive teaching), and the effect of teacher behavior on child outcomes.
Empowering career pathways: integrating self-regulation strategies with career counseling practices
Authors: Rezaiee Mohsen , Kareshki Hossein 
Published: November 2024

IntroductionThis study explores the integration of self-regulation strategies into career counseling to enhance career development. It outlines the rationale behind this integration and sets the objectives of providing practical strategies for educators and counselors to support career paths.MethodsThe theoretical framework examines the role of self-regulation in career development and its intersection with career counseling in the modern workforce. Practical applications include self-regulation techniques for career advancement, career counseling interventions, and case studies.ResultsThe application of these strategies is compiled into a resource manual, which includes tools, assessments, and activities for clients, as well as resources for career counselors. This manual serves as a practical toolkit for implementing the guide's recommendations.DiscussionThe conclusion highlights the contributions of the guide, reflecting on the integration of self-regulation and career counseling. Policy implications are discussed, with recommendations for education and workforce development, advocating for the institutionalization of self-regulation in career services. Future research and policy directions are suggested, emphasizing the importance of this integration for educational achievement and personal satisfaction. Overall, the guide offers a novel approach to career counseling, grounded in self-regulation theory and practice, providing a comprehensive resource for enhancing career pathways.
Global trends and research hotspots in perioperative management of lung cancer: a bibliometric analysis from 2004 to 2024
Authors: Jiang Qinling , Wei Zhuheng , Liu Pingping , Li Zonghuai , Jiang Huiqin , Cao Yilin , Zhang Bo , Yan Yuanyuan , He Yulong 
Published: November 2024

ObjectiveThis article aims to analyze the current status and research hotspots of literature related to perioperative management of patients with Lung Cancer and provide reference for future research directions.MethodsThis study conducted a bibliometric analysis of research literature related to perioperative management of Lung Cancer published between 2004 and 2024, retrieved from the Web of Science database. R software and VOSviewer were used for analyzing keyword clusters and research themes, revealing trends and frontiers in this field.ResultsA total of 4,942 studies on perioperative management of lung cancer were included. In recent years, research in this area has shown a global upward trend, with particular focus on surgical risk assessment, complication prevention, and postoperative management. Perioperative biomarkers before and after surgery have emerged as a central focus due to their impact on diagnosis and treatment. The application of novel therapies, such as targeted drugs and immunotherapy, in perioperative management is also becoming a significant research hotspot. Additionally, China has been a leading contributor to research output in this field, demonstrating strong performance in international collaborations.ConclusionPerioperative management is a critical factor influencing the prognosis of Resectable lung cancer patients. Through a systematic analysis of the current status and research hotspots in perioperative management of lung cancer, this study provides valuable references for future clinical practice and research, particularly regarding the integration of novel therapies to optimize patient outcomes.
Investigating the effect of cochlear implant usage metrics on cortical auditory-evoked potential responses in adult recipients post-implantation
Authors: Bogdanov Caris , Goulios Helen , Mulders Wilhelmina H. A. M. , Tavora-Vieira Dayse 
Published: November 2024

IntroductionThis study examines the effect of cochlear implant (CI) device usage metrics on post-operative outcomes in unilateral CI recipients. The primary objective is to investigate the relationship between CI usage frequency (average daily CI use) and duration (total years of CI use) on electrically evoked cortical auditory-evoked potential (eCAEP) response peak latency (ms) and amplitude (μV).MethodsAdult CI users (n = 41) who previously exhibited absent acoustically evoked CAEP responses participated in the study. The peak latency and amplitude of eCAEP P1-N1-P2 responses were recorded, when present for the apical, medial, and basal test electrode contacts. CI duration was defined as the number of years between the date of CI activation and date that eCAEP testing was performed. CI usage frequency was defined as the average number of hours per day of audio processor use, which was recorded using the CI programming software.ResultsOverall, 27 participants (65.85%) exhibited detectable eCAEP responses across one or more electrode contacts. Among these, 18 participants (43.9%) elicited eCAEP responses at all three electrode contacts, while 7 (17.07%) showed responses at two contacts, and 2 (4.88%) at one contact. For the remaining 14 participants (34.15%), eCAEP responses were either absent or undetectable. CI usage frequency (average daily CI use [hours/day]) was captured for 32 (78%) of the participants (median 10.35 h/day, range 0.2–16 h/day). Participants with present eCAEP responses for the basal electrode (n = 14) showed significantly higher CI usage frequency (11.8 h/day, p = 0.026) compared to those with non-detectable responses (6.25 h/day). An association was found between higher CI usage frequency and reduced N1 (p = 0.002), P2 (p = 0.0037) and P1-N1 inter-peak (p = 0.015) response latency (ms). While CI duration (total CI use [years]) did not differ significantly between groups based on the presence of eCAEP responses, an association was found between greater CI duration and increased eCAEP response amplitude (μV) for the P2 (p = 0.008) and N1-P2 peak-peak (p = 0.009) response components.DiscussionAdditionally, most (65.85%) participants who previously exhibited absent acoustic CAEP responses developed eCAEP responses after consistent CI use and increased CI experience. These findings may suggest a potential for cortical plasticity and adaptation with consistent CI use over time. Recognizing the impact of device usage metrics on neural responses post-implantation enhances our understanding of the importance of consistent daily CI use. Overall, these findings contribute to addressing the variability among CI users, improving post-operative outcomes and advancing the standard of personalized care in auditory rehabilitation.
Aerobic exercise attenuates insulin resistance via restoring branched chain amino acids homeostasis in obese mice
Authors: Cao Wei , Liu Yajin , Wei Hao , Dong Yunfeng , Sun Haipeng , Zhang Xuejiao , Qiu Junqiang 
Published: November 2024

IntroductionEmerging evidences suggests that the disrupted branched-chain amino acids (BCAAs) homeostasis and elevated BCAAs promote obesity-related insulin resistance (IR). Exercise improves insulin sensitivity. However, whether BCAAs plays a role in the exercise-attenuated IR remains to be fully investigated.MethodsIn this study, male C57BL/6J mice were induced to become diet-induced obese (DIO) and served as subjects. The initial investigation focused on the impact of exercise on IR and BCAAs. The DIO mice were randomly assigned to either a sedentary group (CON, n = 16) or an exercise group (EX, n = 16). The EX group underwent a 12-week aerobic exercise regimen on a treadmill. After 12-week, plasma BCAAs and branched-chain keto acids (BCKAs) were measured by liquid chromatography-mass spectrometry, glucose tolerance test (GTT) and insulin tolerance test (ITT) were performed, and the expression and phosphorylation of BCAAs catabolic proteins, as well as AKT T308 in gastrocnemius muscle and liver tissues, were evaluated using western blotting. Subsequently, the study explored the role of BCAAs in enhancing IR through exercise. Mice were randomly allocated into 4 groups: sedentary group (CON, n = 8), sedentary with BCAAs supplementation group (CON+BCAA, n = 8), exercise group (EX, n = 16), and exercise with BCAAs supplementation group (EX+BCAA, n = 16). The exercise protocol was as above. Mice in the BCAAs supplemented groups received drinking water containing 2% BCAAs. After 12-week, plasma BCAAs and BCKAs were measured, GTT and ITT tests were performed, and the phosphorylation of AKT T308, as well as p70S6K T389 in gastrocnemius muscle and liver, were compared between the EX group and the EX+BCAA group. Additionally, the phosphorylation of AMPKα T172 in both tissues was measured across all four groups.Results12-week aerobic exercise improved insulin sensitivity in DIO mice while inducing BCAAs catabolic protein expression in skeletal muscle and liver, and reducing the plasma BCAAs level. Importantly, BCAAs supplementation elevated the plasma level of BCAAs and counteracted the exercise-attenuated IR. In skeletal muscle and liver tissues, BCAAs supplementation impaired the exercise-improved insulin signaling without enhancing mammalian target of rapamycin activity. AMPK activity was enhanced by aerobic exercise, which was abolished by BCAAs supplementation.ConclusionAerobic exercise attenuated insulin resistance via restoring BCAAs homeostasis and AMPK activity. The impacts of BCAAs intake on the metabolic effects of exercise sheds light on the combined exercise and nutrition intervention strategy for diabetes management.
Mediation effects of metabolites and sex hormones on the relationship between body mass index and breast cancer: Mendelian randomization analysis and mediation analysis
Authors: Yang Yanjiang , Chen Min , Yang Wenwen 
Published: November 2024

BackgroundObservational investigations have indicated a notable correlation between body mass index (BMI) and breast cancer (BC). Nevertheless, the precise biological pathways driving this correlation remain ambiguous. Consequently, we utilized Mendelian randomization (MR) techniques to explore the causative link between BMI and genetic predisposition to BC, as well as the potential intermediary influences.MethodsUtilizing extensive cohorts sourced from publicly accessible genome-wide association studies (GWAS) datasets of European populations, we conducted Mendelian randomization (MR) analysis. The primary method employed was the Inverse Variance Weighted (IVW) model. We evaluated both heterogeneity and horizontal pleiotropy. Our MR analysis unveiled several metabolites and sex hormones as mediators in the association between BMI and BC.ResultsThe IVW model indicated significant negative causal correlations between BMI and BC, ER+BC, and ER-BC. Thirty-five metabolites, thirty-three metabolites and sex hormones, and fifteen metabolites respectively mediated the causal effects of BMI on BC, ER+BC, and ER-BC. Furthermore, our study found that BMI influences BC risk through different mediating factors; BMI increases ER+BC risk through the pathway of sex hormones (biologically available testosterone) and decreases the causal relationship of BC risk through multiple metabolite pathways.ConclusionThis study discovered that BMI increases ER+BC risk through the pathway of sex hormones (biologically available testosterone), and decreases BC risk through multiple metabolite pathways causally. These discoveries could offer insights into the development of preventive strategies and interventions for BC, while further investigations should delve into alternative feasible biological pathways.