bluuebunny/crossref_metadata_2025_split huggingface dataset:
Final results of a phase 2, open‐label study of indisulam, idarubicin, and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high‐risk myelodysplastic syndrome
Authors: Assi Rita , Kantarjian Hagop M. , Kadia Tapan M. , Pemmaraju Naveen , Jabbour Elias , Jain Nitin , Daver Naval , Estrov Zeev , Uehara Taisuke , Owa Takashi , Cortes Jorge E. , Borthakur Gautam 
Published: April 2018

BACKGROUNDIndisulam possesses anticancer properties through down‐regulation of various cell‐cycle checkpoint molecules, thereby blocking the phosphorylation of retinoblastoma protein and inducing p53 and p21. Indisulam exhibits synergy with nucleoside analogs and topoisomerase inhibitors.METHODSThe authors designed a phase 2 study of indisulam in combination with idarubicin and cytarabine in patients who had relapsed/refractory acute myeloid leukemia AML and high‐risk myelodysplastic syndrome. In stage 1, patients received intravenous indisulam at 400 mg/m2 on days 1 and 8 of a 28‐day cycle. If they had no response, then patients received same dose schedule of indisulam followed by intravenous idarubicin 8 mg/m2 daily for 3 days and cytarabine 1.0 g/m2 over 24 hours daily on days 9 through 12 (for those aged < 60 years) or days 9 through 11 (for those aged > 60 years) of a 28‐day cycle. Primary endpoints included the overall response rate, and secondary objectives included overall survival.RESULTSForty patients were enrolled. Of the 37 evaluable patients, 31 received indisulam with chemotherapy. Of these, 11 (35%) responded for a median duration of 5.3 months. The estimated 1‐year overall survival rate was 51% for responders compared with 8 % for nonresponders (P < .001). The most common grade ≥3 nonhematologic toxicities were electrolyte abnormalities (50%) and febrile neutropenia (28%).CONCLUSIONSThe combination of indisulam with idarubicin and cytarabine yielded a 35% response rate in heavily pretreated patients with AML. With emerging data identifying the expression of DCAF15 (DDB1 and CUL4‐associated factor 15) as a potential biomarker for activity, the combination of indisulam with idarubicin and cytarabine should be studied in a biomarker‐driven trial or in patients who have splicing factor mutations. Cancer 2018;124:2758‐65. © 2018 American Cancer Society. Cancer 2018;124:2758‐2765. © 2018 American Cancer Society
Symptom and function profiles of men with localized prostate cancer
Authors: Reeve Bryce B. , Tan Xianming , Chen Ronald C. , Usinger Deborah S. , Pinheiro Laura C. 
Published: April 2018

BACKGROUNDMen diagnosed with localized prostate cancer seek information on how treatment options may impact their health‐related quality of life (HRQOL). The authors used latent profile analysis (LPA) to group men according to their symptom burden and functional status and to identify patient characteristics associated with each HRQOL profile.METHODSPatients completed the Patient‐Reported Outcomes Measurement Information System and the Expanded Prostate Index Composite measures 3 months after treatment initiation. Anxiety, depression, fatigue, sleep disturbance, pain, diarrhea, urinary obstruction, urinary incontinence, erectile function, and sex satisfaction were modeled jointly using LPA, and the analysis was adjusted for covariates to examine associations between patient characteristics and profiles.RESULTSOne‐third of the 373 men were not non‐Hispanic white (26% were black). Four LPA profiles were identified. Men who experienced the “best HRQOL” were less likely to receive treatment, to be older, and to smoke. Men in the second best profile experienced symptoms similar to men in the best HRQOL group but reported poor sexual and urinary function, because they were more likely to receive therapy. The third profile included men with increased symptom burden and poor functioning who were likely to undergo prostatectomy and to have increased comorbidity. The “worst HRQOL” group experienced the worst symptoms and the poorest functioning, and these men were more likely to be younger, to have more comorbidities, and to smoke.CONCLUSIONSLPA revealed that men who receive the same treatment can experience very different HRQOL impact. Understanding the factors most associated with poorer HRQOL allows clinicians to focus their care on individuals most in need of symptom management and support. Cancer 2018;124:2832‐2840. © 2018 American Cancer Society
Melancholia and cancer: The bladder cancer narrative
Authors: Correa Andres F. , Smaldone Marc C. 
Published: April 2018

Patients who undergo treatment for muscle‐invasive bladder cancer have a 50% risk of developing a posttreatment psychiatric diagnosis, the most prevalent of which is substance abuse, and such diagnoses are associated with worse cancer‐specific and overall survival. Further research into the application of distress instruments is paramount for the early identification and treatment of at risk patients.See referenced original article on pages 3127‐35, this issue.
Fundamentals of Acoustic Cytometry
Authors: Ward Michael D. , Kaduchak Gregory 
Published: April 2018

AbstractAcoustic cytometry uses radiation pressure forces instead of or in addition to hydrodynamic focusing to position cells or particles in a flowing stream for analysis. Commercial implementations to date combine both hydrodynamic and acoustic focusing together to enable high precision analysis of a broad dynamic range of volumetric sample input rates up to an order of magnitude higher than is practical with hydrodynamic focus alone. This capability allows great flexibility in reducing assay time or modifying or eliminating concentration requirements or concentration steps in sample preparation protocols. It also provides a practical method for processing sub‐microliter volumes using sample dilution. In order to take full advantage of this dynamic range, it is necessary to understand the fundamental benefits and limitations of acoustic focusing as applied to flow cytometry. © 2018 by John Wiley & Sons, Inc.
Isolation of Murine Skin Resident and Migratory Dendritic Cells via Enzymatic Digestion
Authors: Kashem Sakeen W. , Kaplan Daniel H. 
Published: April 2018

AbstractDendritic cells (DCs) are a highly specialized subset of professional antigen‐presenting cells (APCs) that reside in peripheral and lymphoid tissues. DCs capture antigen in the periphery and migrate to the lymph node where they prime naïve T cells. In addition, DCs have been recently appreciated to have function in innate immunity within tissues. In the skin, heterogeneous populations of DCs reside within the epidermis and the dermis. Analysis of the cutaneous DC subsets is complicated by requirements of distinct enzymatic digestion protocols for isolation of APCs from distinct anatomical compartments of the skin. Here, specific approaches for isolation of DCs from the epidermis, dermis, and the skin‐draining lymph nodes of mice are described. © 2018 by John Wiley & Sons, Inc.
Tuning the Key Properties of Singlet Oxygen‐Responsive Acene‐Doped Conjugated Polymer Nanoparticles
Authors: Frausto Fanny , Thomas Samuel W. 
Published: April 2018

AbstractThis paper describes the effects of nanoparticle composition on energy transfer and ratiometric fluorescent response to singlet oxygen (1O2) of a series of acene‐doped conjugated polymer nanoparticles (CPNs). These CPNs are comprised of the conjugated polymer poly [(9,9‐dioctylfluorenyl‐2,7‐diyl)‐alt‐co‐(1,4‐benzo‐(2,1′,3)‐thiadiazole) (F8BT) as the polymer donor matrix and one of four different 1O2‐sensitive acene acceptor dopants. In the dense chromophore matrix of the CPN, the quantum yield of fluorescence of each acene‐doped CPN matches or exceeds that of the undoped F8BT CPN. Reactivity with 1O2 of the acenes follows the same trend in the solid matrix of CPNs as previously found in dilute solution. The doping levels of acenes in the CP matrix have important implications for both the extent of energy transfer and the subsequent rates of ratiometric response. This study therefore lends important insight into the rational design of luminescent, stimuli‐responsive CPNs and the reactivity of singlet oxygen in heterogeneous material systems.
Hierarchically Structured FeNiOxHy Electrocatalyst Formed by In Situ Transformation of Metal Phosphate for Efficient Oxygen Evolution Reaction
Authors: Wu Xiujuan , Zhao Yimeng , Xing Tongyu , Zhang Peili , Li Fusheng , Lee Husileng , Li Fei , Sun Licheng 
Published: April 2018

AbstractA simple and low‐cost fabrication method is needed to obtain effective and robust heterogeneous catalysts for the oxygen evolution reaction (OER). In this study, an electrocatalyst FeNiOxHy with a hierarchical structure is synthesized on nickel foam by a simple fabrication method through anion exchange from a metal phosphate to a metal hydroxide. The as‐fabricated FeNiOxHy electrode requires overpotentials of 206 and 234 mV to deliver current densities of 10 and 50 mA cm−2, respectively. The catalytic performance of FeNiOxHy is superior to that of most previously reported FeNi‐based catalysts, including NiFe layered double hydroxide. The catalyst also shows good long‐term durability at a current density of 50 mA cm−2 over 50 h with no activity decay under 1 m KOH. By comparison to the directly electrodeposited FeNi hydroxide in morphology and electrochemical properties, the improved activity of the catalyst could be mainly attributed to an enhancement of its intrinsic activity, which was caused by the anion exchange of phosphate to (oxy)hydroxide. Further studies by cyclic voltammetry indicated a stronger interaction between Ni and Fe from the negative shift of the oxidation peak of Ni2+/Ni3+ in comparison with reported FeNiOxHy, which promoted the generation of active Ni3+ species more easily. This work may provide a new approach to the simple preparation of effective and robust OER catalysts by anion exchange.
Selective Fragmentation of Biorefinery Corncob Lignin into p‐Hydroxycinnamic Esters with a Supported Zinc Molybdate Catalyst
Authors: Wang Shuizhong , Gao Wa , Li Helong , Xiao Ling‐Ping , Sun Run‐Cang , Song Guoyong 
Published: April 2018

AbstractLignin is the largest renewable resource of bioaromatics, and the catalytic fragmentation of lignin into phenolic monomers is increasingly recognized as an important starting point for lignin valorization. Herein, we report that ZnMoO4 supported on MCM‐41 can catalyze the fragmentation of biorefinery technical lignin, enzymatic mild acidolysis lignin, and native lignin derived from corncob to yield lignin oily products that contain 15–37.8 wt % phenolic monomers, in which the high selectivities towards methyl coumarate (1) and methyl ferulate (2) were obtained (up to 78 %). The effects of some key parameters such as the influence of the solvent, reaction temperature, time, H2 pressure, and catalyst dosage were examined in view of activity and selectivity. The loss of Zn from the catalyst is discussed as the primary cause of deactivation, and the catalytic activity and selectivity can be well preserved in at least six runs by thermal calcination. The high selectivity to 1 and 2 leads to their easy separation and purification from lignin oily product to provide sustainable monomers for the preparation of functional polyether esters and polyesters.
Quantification of airway fibrosis in asthma by flow cytometry
Authors: Reichard Andrew , Wanner Nicholas , Stuehr Eric , Alemagno Mario , Weiss Kelly , Queisser Kimberly , Erzurum Serpil , Asosingh Kewal 
Published: April 2018

AbstractAirway fibrosis is a prominent feature of asthma, contributing to the detrimental consequences of the disease. Fibrosis in the airway is the result of collagen deposition in the reticular lamina layer of the subepithelial tissue. Myofibroblasts are the leading cell type involved with this collagen deposition. Established methods of collagen deposition quantification present various issues, most importantly their inability to quantify current collagen biosynthesis occurring in airway myofibroblasts. Here, a novel method to quantify myofibroblast collagen expression in asthmatic lungs is described. Single cell suspensions of lungs harvested from C57BL/6 mice in a standard house dust mite model of asthma were employed to establish a flow cytometric method and compare collagen production in asthmatic and non‐asthmatic lungs. Cells found to be CD45–αSMA+, indicative of myofibroblasts, were gated, and median fluorescence intensity of the anti‐collagen‐I antibody labeling the cells was calculated. Lung myofibroblasts with no, medium, or high levels of collagen‐I expression were distinguished. In asthmatic animals, collagen‐I levels were increased in both medium and high expressers, and the number of myofibroblasts with high collagen‐I content was elevated. Our findings determined that quantification of collagen‐I deposition in myofibroblastic lung cells by flow cytometry is feasible in mouse models of asthma and indicative of increased collagen‐I expression by asthmatic myofibroblasts. © 2018 International Society for Advancement of Cytometry
Achieving maximum bit rate in a cognitive radio network with physical layer network coding
Authors: Khosroazad Somayeh , Abedi Ali , Neda Naaser 
Published: April 2018

SummaryIn this paper, the power allocation problem in a relay‐assisted cognitive radio network (CRN) is considered where the secondary users exchange information in an interweave mode on the basis of physical layer network coding. In order to enhance the capacity of CRN, using multiple‐input multiple‐output and orthogonal frequency division multiplexing has become very popular in the literature. This paper goes one step further to improve the throughput of secondary users using physical layer network coding by drawing off the transmission time. The main goal is to maximize the capacity of CRN, while keeping the total interference imposed on the primary users under a certain threshold. An optimal solution to this power allocation problem with limited relay power constraint, due to the limited budget, is derived; however, because of the high complexity of this method, an efficient suboptimal solution is also proposed.
Web service discovery utilizing logical reasoning and semantic similarity
Authors: Fang Mingzhe , Wang Dandan , Mi Zhenqiang , Obaidat Mohammad S. 
Published: April 2018

SummaryWeb service discovery facilitates the implementation of complex and reconfigurable applications in service‐oriented architecture, such as service selection, composition, and provision. This paper presents an approach for semantic and automated Web service discovery. Our approach to semantic Web service discovery consists of ontology‐based service preprocessor, reasoning‐based service filter, and parameter‐based service matcher. An important feature of this approach is that the relationship among concepts in ontology is quantified and considered as an important factor in the matching process, which results in high precision and recall. Additionally, we propose a filtering method based on logical reasoning to preprocess the large amount of Web services. Through the filtering method, Web services which are feasible in logic are selected to be matched with user requests. So there is a great improvement in the run‐time performance of service discovery approach. Experiments show that our approach is feasible and effective to discover the required Web services.
Label‐QoS switching protocol for quality of service assurance in dynamic swarm robot local network
Authors: Irawan Addie , Mat Jusoh Mohd Falfazli , Abas Mohammad Fadhil 
Published: April 2018

SummaryThis paper presents the modeling and analysis of a proposed label–quality of service (QoS) switching protocol for heterogeneous robot in a swarm. Establishing the data communication and network in multirobot task allocation is an important aspect in robot collaboration. Instead of passing the data through the cloud network, each robot can be configured as a node in its swarm for intercommunication. This research was conducted to model and propose aggregation and classification methods in a swarm robot network inspired from multiprotocol label switching, namely, label‐QoS switching protocol. Each packet of data is forwarded with a proposed 2‐side label values that are concerned with addressing and QoS. This proposed protocol was applied in each of the node's routing, and it was set up with forwarding information table. The simulation and analysis were conducted in 2 situations: (1) with a constant n–label switch mobile robot and a number of packet data increasing with time and (2) with a constant number of packet and varying n–label switch mobile robot by time. With reference to the network parameter performances, it shows that the anomaly treatment by the proposed protocol is able to prioritize the data forwarding between the robots at the edge of the swarm with class of service although the robot community at the center is increasing or getting crowded.
PAPR reduction for OFDM‐based visible light communication systems using proposed hybrid technique
Authors: Freag Haitham , Hassan Emad S. , El‐Dolil Sami A. , Dessouky Moawad I. 
Published: April 2018

SummaryOrthogonal Frequency Division Multiplexing (OFDM) is utilized with visible light communication (VLC) systems to decrease the impacts of inter‐symbol interference and to achieve communication with high speed of data transmission and huge bandwidth. In any case, the main problem in OFDM‐based VLC systems is high peak‐to‐average power ratios (PAPRs). This paper proposes a hybrid PAPR reduction technique based on signal transformation combined with clipping. The Hadamard transform is used in the proposed technique to reduce the PAPR without affecting the bit error rate (BER) of the VLC systems. The optimum clipping threshold at which the PAPR is reduced simultaneously with the improvement the BER of the VLC systems is also determined. The performance of the proposed system is assessed in terms of complementary cumulative distribution function and the BER. The obtained results demonstrate that the proposed procedure can simultaneously decrease the PAPR and achieve good BER performance compared to the OFDM‐based VLC system.
A meta‐analysis of the relationships between body checking, body image avoidance, body image dissatisfaction, mood, and disordered eating
Authors: Walker D. Catherine , White Emily K. , Srinivasan Vamshek J. 
Published: April 2018

AbstractObjectiveBody checking (BC) and body image avoidance (BIA) have been proposed as etiological and maintaining mechanisms for eating disorder (ED) pathology. To date, no comprehensive review summarizes the relationships of BC and BIA with ED pathology, body image dissatisfaction, or mood/affect.MethodMeta‐analyses examined the relationships of BC and BIA with ED pathology, body image dissatisfaction, and mood/affect. Gender, publication status, and presence or absence of ED diagnoses were examined as potential moderators.ResultsResults showed strong relationships between BC and ED pathology (ρ = 0.588) and BC and body image dissatisfaction (ρ = 0.631) and a moderate relationship between BC and mood/affect (ρ = 0.385). Similarly, results showed strong relationships between BIA and ED pathology (ρ = 0.553) and BIA and body image dissatisfaction (ρ = 0.543) and a moderate relationship between BIA and mood/affect (ρ = 0.392). Overall, limited evidence supported publication bias; however, publication bias may exist in the relationship between BIA and body image dissatisfaction in the literature. Subgroup moderator analyses suggested that gender moderates the strength of the relationships between BC and ED pathology, body image dissatisfaction, and mood/affect and between BIA and body image dissatisfaction.DiscussionResults are consistent with cognitive‐behavioral models of ED pathology that suggest BC and BIA are behavioral expressions of overvaluation of weight and shape. Notably, more published research has investigated BC than BIA. Future studies, incorporating methods such as meta‐analytic structural equation modeling, should examine these variables to further test cognitive‐behavioral models of ED development and maintenance.
Factors influencing the establishment and growth of tree seedlings at Subarctic alpine treelines
Authors: Kambo Dasvinder , Danby Ryan K. 
Published: April 2018

AbstractSignificant treeline advance can only occur with successful establishment, growth, and survival of new seedlings. Several studies have examined microsite factors at single locations to explain the presence/absence of seedlings at treeline. We conducted a much larger observational study and included multiple factors to determine (1) which variable(s) was/were most important, (2) whether their importance differed between aspects, and (3) whether the same variables explained variation in seedling growth and damage. We analyzed five biophysical and six shrub variables along four forest–tundra ecotones in southwest Yukon at 640 points. The model that best explained seedling occurrence was similar between north‐ and south‐facing slopes. Of all variables, seedling occurrence was best explained by the proximity, height, and upslope orientation of shrubs (relative to the seedling). The data indicate an optimal range of shrub cover, which differed with aspect. On north‐facing slopes, seedlings occurred most often when shrub cover exceeded 13%, while on south‐facing slopes seedlings occurred most when shrub cover was between 9% and 72%. We also found that with the exception of shrub‐related factors, very few biophysical variables explained size and growth characteristics and damage of tree seedlings, suggesting that the relative strength and importance of variables change depending on the life stage and size of the tree seedling. Collectively, our results demonstrate a non‐random distribution of seedlings in the forest–tundra ecotone, suggesting that as shrub distributions change with climate change, colonization sites for seedlings will also be influenced.
Regional variations in occupancy frequency distribution patterns between odonate assemblages in Fennoscandia
Authors: Korkeamäki Esa , Elo Merja , Sahlén Göran , Salmela Jukka , Suhonen Jukka 
Published: April 2018

AbstractOdonate (damselfly and dragonfly) species richness and species occupancy frequency distributions (SOFDs) were analyzed in relation to geographical location in standing waters (lakes and ponds) in Fennoscandia, from southern Sweden to central Finland. In total, 46 dragonfly and damselfly species were recorded from 292 waterbodies. Species richness decreased to the north and increased with waterbody area in central Finland, but not in southern Finland or in Sweden. Species occupancy ranged from 1 up to 209 lakes and ponds. Over 50% of the species occurred in <10% of the waterbodies, although this proportion decreased to the north. In the southern lakes and ponds, none of the species occurred in all lakes, whereas in the north, many species were present in all of the studied waterbodies. The dispersal ability of the species did not explain the observed species occupancy frequencies, but generalist species with a large geographical range occurred in a higher percentage of the waterbodies. At Fennoscandia scale, we found that the unimodal satellite pattern was predominant. However, at smaller scale, we found geographical variations in odonate speciesSOFDpatterns. The most southern communities followed the unimodal satellite‐dominant pattern, whereas in other regions, communities fitted best with the bimodal core–satellite patterns. It seems that the richer species pool in the southern locations, and the larger distribution range of the northern species, skewed the unimodal pattern into a bimodal satellite‐dominant pattern.