bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival improvement over time in renal cell carcinoma treated with nephrectomy: A longitudinal propensity score‐matched study
Authors: Kishitani Kenjiro , Taguchi Satoru , Tanaka Koji , Danno Tetsuya , Oshina Takahiro , Fujii Yoichi , Kamei Jun , Akiyama Yoshiyuki , Kakutani Shigenori , Sato Yusuke , Yamada Yuta , Niimi Aya , Yamada Daisuke , Kume Haruki 
Published: October 2024

ObjectiveSurgical treatment for renal cell carcinoma (RCC) has drastically evolved for the past 30 years. However, survival outcomes of RCC according to times have not been fully elucidated, especially in the real‐world setting. This study aimed to assess the survival improvement over time in RCC treated with nephrectomy by analyzing a longitudinal cohort using propensity score matching (PSM).MethodsWe retrospectively reviewed 960 patients with RCC who underwent radical or partial nephrectomy between 1981 and 2018. Patients were divided into two groups according to the time of surgery (1981–1999 vs. 2000–2018). Using PSM, overall survival (OS), cancer‐specific survival (CSS), and recurrence‐free survival (RFS) were compared between the two groups.ResultsOverall, 255 and 705 patients underwent surgery in the earlier (1981–1999) and recent (2000–2018) eras, and PSM derived a matched cohort of 466 patients (233 patients per each group). All patients in the earlier era cohort received open surgeries, whereas about a half (47.4%) of patients in the recent era cohort received minimally‐invasive (laparoscopic/robotic) surgeries. After PSM, 137 (29.4%) patients developed recurrence, 105 (22.5%) died of RCC, and 113 (24.2%) died from other causes, with a median follow‐up period of 90 months. The recent era cohort had significantly longer OS, CSS, and RFS than the earlier era cohort.ConclusionsPatients with RCC treated in the recent era (2000–2018) showed significantly longer survival than those treated in the earlier era (1981–1999). The improved survival might be attributable to the prevalence of minimally‐invasive (laparoscopic/robotic) surgeries.
International migration and the advent of a new demographic era
Authors: Fargues Philippe 
Published: October 2024

AbstractThe paper explores whether international migration is linked to currently decreasing levels of fertility in high birth rates countries, thereby to the advent of a stage of population degrowth at the world's level. Methodology is in two steps. First, a global dataset is assembled comprising 13 variables for each country. For the country itself: emigrant stock, total fertility rate, girls' enrolment rate, women's labour force participation, global gender gap, and income per capita; for a fictitious average region of destination of migrants originating from this specific country, the last six variables. In the second step, links between origin and destination countries in terms of fertility levels and determinants are analysed using bivariate correlations. A remarkable fact emerges, namely national levels of fertility and their determinants vary quasi perfectly parallel at both ends of international migration corridors. Fertility at origin is not correlated to any phenomenon as much as to fertility, girls' school enrolment and gender equity at destination. Three complementary hypotheses explaining this apparently puzzling fact are discussed: transmission of norms by migrants; cultural similarities at both ends of migrant corridors; and congruency between the global diffusion of norms and the global migration of people. The conclusion highlights the original contribution of the paper, both to the demographic discipline (migration should also be dealt with as a remote determinant of fertility) and political debates on migration (erecting barriers to migration works against the preservation of earth).
Analysing the Impact of Socioeconomic Factors on Mental Health Differences in Chinese Society: Integrating Cultural, Psychological and Technological Perspectives
Authors: Luan Dianfei , Mu Qichen 
Published: October 2024

ABSTRACTMental health (MH) differences remain an issue in contemporary Chinese society, with various factors influencing individuals' well‐being. This study investigates the complex connection between results related to psychological wellness and social issues, integrating cultural, psychological and technological perspectives. Through a quantitative research methodology, data were collected from 1000 individuals using a questionnaire survey and analysed using SPSS software. The study's findings shed light on the impact of socioeconomic status (SES) on MH stigma, help‐seeking behaviour and overall well‐being. The findings identify that lower SES was associated with heightened levels of MH stigma and decreased the search for assistance actions. Cultural beliefs emphasising MH stigma and societal expectations were identified as mediators in the connection involve SES and MH outcomes. Digital technology use emerged as a moderator, indicating that higher levels of technology utilisation were linked to reduced disparities in accessing MH resources. The novelty of this study lies in its comprehensive examination of the multifaceted factors influencing MH disparities within Chinese society. Additionally, psychological factors such as resilience and social support were observed to mitigate the negative lower SES's effect on MH consequences. The interaction between SES and cultural factors was found to predict MH outcomes, with lower SES exacerbating the effects of MH stigma and cultural barriers.
Banging My Head Against a Brick Wall! Enablers and Barriers to Nurse Practitioners Delivering Opioid Agonist Treatments in Regional/Rural Victoria, Australia
Authors: Patil Tejaswini , Dostal Jana , Nielsen Suzanne , Buus Niels , Molloy Pauline , Armstrong Ferghal , Coventry Jessica , Shlonsky Aron 
Published: October 2024

ABSTRACTThe Victorian government's Alcohol and other drugs (AOD) workforce policy calls for greater recruitment of alcohol and other drugs nurse practitioners (AODNPs). However, frontline organisations in Victoria report several systemic barriers to their recruitment and retention. Additionally, there is scant Australian literature that examines the experiences of AODNP in opioid agonist treatment (OAT) provision in regional/rural areas. This research aims to address this gap by examining the AODNP workforce issues in delivering pharmacotherapy treatments in regional/rural areas of Victoria. Using an interpretative phenomenological approach, we conducted qualitative, in‐depth interviews with 11 OAT prescribing AODNP's working in regional or rural Victoria. We analysed transcripts using reflective thematic analysis and generated three themes: (1) Professional motivations and values, (2) Enablers to professional role and (3) Barriers to professional role. The findings suggest that AODNPs in regional/rural areas are a dedicated workforce who provide holistic and integrated care for OAT clients. AODNPs play an important role in reducing and providing timely and subsidised health care for OAT clients living in regional/rural locations. AODNPs face many systemic and organisational barriers. These include inadequate funding for AODNP positions to prescribe pharmacotherapy treatments, lack of understanding of the AODNP professional role at the executive/management level within organisations and irregular access to supervision, mentoring, training and education. Also, endemic stigma in the health system acts as a barrier in recruiting and supporting AODNP positions that focus on care for OAT clients.
Concept Analysis of Psychosocial Distress Among African American and Latine Men Who Have Sex With Men: Implications for HIV Care
Authors: Payton Isaac K. , Starkweather Angela R. , Westmoreland Drew A. , Canidate Shantrel S. , Cook Robert L. , Lyon Debra E. 
Published: October 2024

ABSTRACTAimThe aim of this study is to provide conceptual clarity on psychosocial distress among African American and Latine men who have sex with men living with human immunodeficiency virus.DesignConcept analysis.MethodsThe 8‐step Walker and Avant framework guided the concept analysis of psychosocial distress tailored to this patient population.Data SourcesA literature review was conducted using the research databases PubMed/Medline, PsycINFO, the Cumulated Index of Nursing and Allied Health Literature and Scopus with the selected search terms.ResultsA total of 7 articles were retrieved and analysed to explicate the antecedents, attributes, and consequences of psychosocial distress in this population. Four cases were developed to further clarify the concept of psychosocial distress; a model case, borderline case, related case and contrary case.ConclusionAs experienced by African American and Latine men who have sex with men living with human immunodeficiency virus, psychosocial distress is defined as a state of suffering due to uncontrollable structural and/or social factors that threaten the individual's existence and/or livelihood based on their social identity as a racial/ethnic, sexual minority.Implications for the Profession and/or Patient CareThe concept analysis of psychosocial distress can be useful to guide future theory and measurement development to enhance disease‐specific and general health outcomes for sexual and racial/ethnic minoritised men who have sex with men.Reporting MethodNot applicable.Patient or Public ContributionNo patient or public contribution.
Clinical Outcomes of Bulk‐Fill Resin Composite Restorations: A 10‐Year Mapping Review and Evidence Gap Map
Authors: de Menezes Anna Júlia Oliveira , do Nascimento Barbosa Lucas , Leite Juan Vitor Costa , Barbosa Laryssa Mylenna Madruga , Montenegro Robinsom Viégas , Dantas Raquel Venâncio Fernandes , de Souza Grace Mendonça , de Andrade Ana Karina Maciel , Lima Renally Bezerra Wanderley 
Published: October 2024

ABSTRACTObjectiveTo map the evidence regarding the clinical performance of posterior restorations with bulk‐fill resin composites and identify research gaps.Materials and MethodsThis mapping review was conducted following PRISMA‐ScR guidelines for scoping reviews, and its protocol was registered on the Open Science Framework platform. Systematic searches were conducted, considering studies published between 2013 and February 2024 in the PubMed, Embase, and Cochrane databases. Clinical studies investigating the performance of bulk‐fill resin composite restorations in class I and/or class II preparations with increments of 4 to 5 mm were included.ResultsA total of 147 articles were identified, and based on the eligibility criteria, 26 studies were selected for descriptive analysis. Of the reviewed studies, 73% (n = 19) investigated high‐viscosity bulk‐fill composites, while 30% (n = 8) focused on low‐viscosity bulk‐fill composites. Evaluation periods ranged from 1 week to 10 years. Reported annual failure rates varied from 0% to 3%, with survival rates between 78.9% and 100%.ConclusionsBulk‐fill resin composites of high viscosity were the most analyzed in the published studies, with evaluation periods of up to 10 years. The review of available scientific evidence showed clinically acceptable performance for composite bulk‐fill restorations, with high survival rates and minimal annual failure rates. There is a need for long‐term clinical studies on bulk‐fill resin composites.Clinical SignificanceThis review demonstrates that both high and low‐viscosity bulk‐fill resin composites exhibit satisfactory clinical performance, which can help clinicians optimize chairside time. However, it is important to highlight the need for further studies with longer follow‐up periods.
Look before you leap: Are increased recycling efforts accelerating microplastic pollution?
Authors: Kahlert Sebastian , Bening Catharina R. 
Published: October 2024

AbstractTo fight plastic pollution and reach net‐zero ambitions, policy and industry set goals to increase the recycling of plastics and the recycled content in products. While this ideally reduces demand for virgin material, it also increases pressure on recyclers to find suitable endmarkets for the recyclate. This may lead to two effects: a multiplication of recycled content in applications already made of plastic and a substitution of non‐plastic materials with cheap, low‐quality recyclate. Both areas of application may be sources of microplastic (MP) pollution. Combined with the inherent degradation of recyclate during its lifecycle, but also during recycling, we expect the increase in recycled content will subsequently lead to an increase in MP pollution. We propose a framework to investigate the risk of MP generation through plastic applications throughout their subsequent lifecycle of production, use phase, and end of life. We apply the framework to two prominent examples of recyclate endmarkets, that is, textiles and wood–plastic, and point out where the degradation effects can cause higher release. To conclude, we outline a research agenda to support policymakers in their decision making on specifying targets for recycling and recycled content.
Rural women's voices revealing perceptions about decisions on where to give birth in Gabon: A qualitative study
Authors: Horikoshi Haruka , Horiuchi Shigeko 
Published: October 2024

AbstractObjectiveThis study aimed to clarify the perceptions of rural women about their decisions on where to give birth in Gabon.MethodThis study used a qualitative descriptive design using semi‐structured interviews. Study participants were women at least 20 years old and had given birth within the past 2 years. The study area was approximately 25–30 km from the capital of Gabon. Data collection was conducted between May and mid‐July 2023. The interview guide was based on the Ottawa Decision Support Framework (ODSF) 2020 model. The data obtained were analyzed using content analysis for “perceptions in deciding the place of birth.”ResultsA total of 18 women participated in the study. Six categories of reasons were identified for women's choice of birth location: (1) childbirth environment with physical safety; (2) childbirth environment with psychological safety; (3) physical accessibility; (4) affordable health facilities; (5) concerns about homebirth risks; and (6) unpleasant aspects of the hospital. Items (1)–(4) were the reasons for actively choosing the hospital as a birth location, whereas items (5) and (6) were the reasons for avoiding a place to give birth.ConclusionsWomen positively perceived and chose facilities that offer physical and mental safety, geographic accessibility, and affordable costs. Conversely, an environment where the safety of the mother and the child is threatened and the lack of respectful maternity care by the medical staff served as deterrents to facility use.
Cross‐species translational paradigms for assessing positive valence system as defined by the RDoC matrix
Authors: Dexter Tyler D. , Roberts Benjamin Z. , Ayoub Samantha M. , Noback Michael , Barnes Samuel A. , Young Jared W. 
Published: October 2024

AbstractFunctions associated with processing reward‐related information are fundamental drivers of motivation, learning, and goal‐directed behavior. Such functions have been classified as the positive valence system under the Research Domain and Criteria (RDoC) criteria and are negatively impacted across a range of psychiatric disorders and mental illnesses. The positive valence system is composed of three comprehensive categories containing related but dissociable functions that are organized into either Reward Responsiveness, Reward Learning, or Reward Valuation. The presence of overlapping behavioral dysfunction across diagnostic mental disorders is in‐part what motivated the RDoC initiative, which emphasized that the study of mental illness focus on investigating relevant behavior and cognitive functions and their underlying mechanisms, rather than separating efforts on diagnostic categories (i.e., transdiagnostic). Moreover, the RDoC approach is well‐suited for preclinical neuroscience research, as the rise in genetic toolboxes and associated neurotechnologies enables researchers to probe specific cellular targets with high specificity. Thus, there is an opportunity to dissect whether behaviors and cognitive functions are supported by shared or distinct neural mechanisms. For preclinical research to effectively inform our understandings of human behavior however, the cognitive and behavioral paradigms should have predictive, neurobiological, and pharmacological predictive validity to the human test. Touchscreen‐based testing systems provide a further advantage for this endeavor enabling tasks to be presented to animals using the same media and task design as in humans. Here, we outline the primary categories of the positive valence system and review the work that has been done cross‐species to investigate the neurobiology and neurochemistry underlying reward‐related functioning. Additionally, we provide clinical tasks outlined by RDoC, along with validity and/or need for further validation for analogous rodent paradigms with a focus on implementing the touchscreen‐based cognitive testing systems.image
Adolescent social stress alters the role of orexin innervation in the hindbrain in male hamsters
Authors: Moran Kevin M. , Enstrom Ava Elana , Jarrell Leah , Khashchuluun Misheel , Tran Anna , Delville Yvon 
Published: October 2024

AbstractJuvenile male hamsters exposed to chronic social stress eat more, gain weight, and have larger fat pads. The purpose of the present study was to address possible changes in food hoarding and orexin/hypocretin innervation in response to social stress. Male hamsters in early adolescence were exposed to a resident‐intruder social stress paradigm or control condition daily for 2 weeks. Metabolism‐related physiological measures and behaviors were tracked, and brains were immunocytochemically labeled for orexin‐A. Our data confirm our previous observations on appetite, weight gain, and obesity, and showed a strong trend toward enhanced food hoarding as in prior studies. In addition, there were no statistically significant differences in orexin innervation in any brain area analyzed. However, unique correlation patterns were observed between orexin innervation and appetite or metabolic outcome. In particular, opposite correlations were observed between groups within the dorsal raphe nucleus, lateral parabrachial nucleus, and nucleus of the solitary tract. These opposite patterns of correlations suggest chronic social stress causes site‐specific alterations in synaptic activity in relation with these behaviors.
Prenatal growth patterns of the upper jaw complex with implications for laryngeal echolocation in bats
Authors: Pommery Yannick , Koyabu Daisuke , Meguro Fumiya , Tu Vuong Tan , Ngamprasertwong Thongchai , Wannaprasert Thanakul , Nojiri Taro , Wilson Laura A. B. 
Published: October 2024

AbstractCraniofacial morphology is extremely diversified within bat phylogeny, however growth and development of the palate in bats remains unstudied. The formation of both midline and bilateral orofacial clefts in laryngeally echolocating bats, morphologically similar to the syndromic and non‐syndromic cleft palate in humans, are not well understood. Developmental series of prenatal samples (n = 128) and adults (n = 10) of eight bat species (two pteropodids, four rhinolophoids, and two yangochiropterans), and two non‐bat mammals (Mus musculus and Erinaceus amurensis), were CT‐scanned and cranial bones forming the upper jaw complex were three‐dimensionally visualised to assess whether differences in palate development can be observed across bat phylogeny. Volumetric data of bones composing the upper jaw complex were measured to quantify palate growth. The premaxilla is relatively reduced in bats compared to other mammals and its shape is heterogeneous depending on the presence and type of orofacial cleft across bat phylogeny. The palatine process of premaxillary bones is lacking in pteropodids and yangochiropterans, whereas the premaxilla is a mobile structure which is only in contact caudally with the maxilla by a fibrous membrane or suture in rhinolophoids. In all bats, maxillary bones progressively extend caudally and palatine bones, in some cases split into three branches, extend caudally so that they are completely fused to another one medially prior to the birth. Ossification of the vomer and fusion of the maxillary and palatine bones occur earlier in rhinolophoids than in pteropodids and yangochiropterans. The vomer ossifies bilaterally from two different ossification centres in yangochiropterans, which is uncommon in other bats and non‐bat mammals. Analysis of ontogenetic allometric trajectories of the upper jaw complex revealed faster development of maxillary, vomer, and palatine bones in yangochiropterans compared to other bats, especially rhinolophoids. Ancestral state reconstruction revealed that yangochiropterans have a higher magnitude of change in ossification rate compared to other bats and E. amurensis a lower magnitude compared to M. musculus and bats. This study provides new evidence of heterochronic shifts in craniofacial development and growth across bat phylogeny that can improve understanding of the developmental differences characterising nasal and oral emission strategies.
Validation of a Photonumeric Scale for Evaluation of Telangiectasia in Rosacea
Authors: Nguyen Lynhda , Seeber Nikolaus , Baron Jens M. , Hammes Stefan , Karsai Syrus , Fischer Tanja C. , Imhof Laurence , Kautz Gerd , Sattler Sonja , Deussing Maximilian , Dierckxsens Cathy , Thiem Alexander , Drosos Zacharias , Grosse‐Buening Stephan , Ganjuur Nomun , Kampmann Anna‐Sophie , May Johanna K. , Schneider Stefan W. , Kerscher Martina , Herberger Katharina 
Published: October 2024

ABSTRACTBackgroundTelangiectasia is a prominent feature of rosacea leading to a high demand for effective treatment. To ensure consistent clinical and scientific evaluations and assess treatment response accurately, standardized assessment tools are necessary for grading the severity of telangiectasia. However, no validated grading scales for this condition are currently available.AimTo develop and validate a photonumeric scale for assessing the severity of telangiectasia in rosacea patients.MethodsThe five‐point photonumeric Telangiectasia in Rosacea Severity Assessment (TRoSA) scale was developed for the severity of telangiectasia in rosacea. Sixteen experts participated in the validation process, evaluating 50 images of rosacea patients in two rounds. Interrater and intrarater reliability were analyzed using the intraclass correlation coefficient (ICC) and weighted kappa, respectively.ResultsInterrater reliability was found to be “almost perfect” in both validation rounds (Round 1: ICC 0.847; Round 2: ICC 0.828). The mean weighted kappa indicated “substantial” intrarater reliability between the two rounds with a weighted kappa of 0.719. A bubble plot of the two rounds illustrated a diagonal order, confirming the consistency of the intrarater agreement.ConclusionsThe TRoSA scale demonstrated high interrater and intrarater reliability indicating that it is a consistent and reproducible tool for grading the severity of telangiectasia in rosacea. This scale can standardize clinical assessments, assisting in diagnosis, treatment planning, and evaluation of therapeutic efficacy.