bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Reperfusion Following Endovascular Thrombectomy
Authors: Kosior Jayme C. , Buck Brian , Wannamaker Robert , Kate Mahesh , Liapounova Natalia A. , Rempel Jeremy L. , Butcher Kenneth 
Published: August 2019

Background and Purpose—
Cerebral perfusion in acute ischemic stroke patients is often assessed before endovascular thrombectomy (EVT), but rarely after. Perfusion data obtained following EVT may provide additional prognostic information. We developed a tool to quantitatively derive perfusion measurements from digital subtraction angiography (DSA) data and examined perfusion in patients following EVT.

Methods—
Source DSA images from acute anterior circulation stroke patients undergoing EVT were retrospectively assessed. Following deconvolution, maps of mean transit time (MTT) were generated from post-EVT DSA source data. Thrombolysis in Cerebral Infarction grades and MTT in patients with and without hemorrhagic transformation (HT) at 24 hours were compared. Receiver operating characteristic modeling was used to classify the presence/absence of HT at 24 hours by MTT.

Results—

Perfusion maps were generated in 50 patients using DSA acquisitions that were a median (interquartile range) of 9 (8–10) seconds in duration. The median post-EVT MTT within the affected territory was 2.6 (2.2–3.3) seconds. HT was observed on follow-up computed tomography in 16 (32%) patients. Thrombolysis in Cerebral Infarction grades did not differ in patients with HT from those without (
P
=0.575). Post-EVT MTT maps demonstrated focal areas of hyperperfusion (n=8) or persisting hypoperfusion (n=3) corresponding to the regions where HT later developed. The relationship between MTT and HT was
U
-shaped; HT occurred in patients at both the lowest and highest extremes of MTT. An MTT threshold <2 or >4 seconds was 81% sensitive and 94% specific for classifying the presence of HT at follow-up.

Conclusions—
Perfusion measurements can be obtained using DSA perfusion with minimal changes to current stroke protocols. Perfusion imaging post-recanalization may have additional clinical utility beyond visual assessment of source angiographic images alone.
First records of six species of mantis shrimp (Stomatopoda) from Korea with a key to the Korean species
Authors: Hwang Hee-Seung , Ahyong Shane T. , Kim Won 
Published: August 2019

Abstract
The Stomatopoda of Korea have, in general, been poorly studied, with eight species recorded to date. A recent study of stomatopods collected by SCUBA diving and commercial fishing trawlers from Korean waters, however, resulted in the discovery of first records of six species from the study area. Among them, four belong to the superfamily Squilloidea Latreille, 1802 [Levisquilla inermis (Manning, 1965), Levisquilla jurichi (Makarov, 1979), Anchisquilla fasciata (De Haan, 1844), and Cloridopsis scorpio (Latreille, 1828)], and two belong to the Lysiosquilloidea Giesbrecht, 1910, one each in Tetrasquillidae Manning & Camp, 1993 [Acaenosquilla latifrons (De Haan, 1844)] and Nannosquillidae Manning, 1980 [Acanthosquilla multifasciata (Wood-Mason, 1895)]. Thus, fourteen species of Stomatopoda are now known from Korea. The superfamily Lysiosquilloidea is reported for the first time from Korean waters. A key to the species of Korean mantis shrimps is provided.
Impact of Ground-Based Remote Sensing Boundary Layer Observations on Short-Term Probabilistic Forecasts of a Tornadic Supercell Event
Authors: Hu Junjun , Yussouf Nusrat , Turner David D. , Jones Thomas A. , Wang Xuguang 
Published: August 2019

Abstract
Due to lack of high spatial and temporal resolution boundary layer (BL) observations, the rapid changes in the near-storm environment are not well represented in current convective-scale numerical models. Better representation of the near-storm environment in model initial conditions will likely further improve the forecasts of severe convective weather. This study investigates the impact of assimilating high temporal resolution BL retrievals from two ground-based remote sensing instruments for short-term forecasts of a tornadic supercell event on 13 July 2015 during the Plains Elevated Convection At Night field campaign. The instruments are the Atmospheric Emitted Radiance Interferometer (AERI) that retrieves thermodynamic profiles and the Doppler lidar (DL) that measures horizontal wind profiles. Six sets of convective-scale ensemble data assimilation (DA) experiments are performed: two control experiments that assimilate conventional and WSR-88D radar observations using either relaxation-to-prior-spread (RTPS) or the adaptive inflation (AI) technique and four experiments similar to the control but that assimilate either DL or AERI or both observations in addition to all other observations that are in the control experiments. Results indicate a positive impact of AERI and DL observations in forecasting convective initiation (CI) and early evolution of the supercell storm. The experiment that employs the AI technique to assimilate BL observations in DA enhances the humidity in the near-storm environment and low-level convergence, which in turn helps forecasting CI. The forecast improvement is most pronounced during the first ~3 h. Results also indicate that the AERI observations have a larger impact compared to DL in predicting CI.
Fluoroquinolones and isoniazid-resistant tuberculosis: implications for the 2018 WHO guidance
Authors: Stagg Helen R. , Bothamley Graham H. , Davidson Jennifer A. , Kunst Heinke , Lalor Maeve K. , Lipman Marc C. , Loutet Miranda G. , Lozewicz Stefan , Mohiyuddin Tehreem , Abbara Aula , Alexander Eliza , Booth Helen , Creer Dean D. , Harris Ross J. , Kon Onn Min , Loebinger Michael R. , McHugh Timothy D. , Milburn Heather J. , Palchaudhuri Paramita , Phillips Patrick P.J. , Schmok Erik , Taylor Lucy , Abubakar Ibrahim 
Published: August 2019

Introduction2018 World Health Organization (WHO) guidelines for the treatment of isoniazid (H)-resistant (Hr) tuberculosis recommend a four-drug regimen: rifampicin (R), ethambutol (E), pyrazinamide (Z) and levofloxacin (Lfx), with or without H ([H]RZE-Lfx). This is used once Hr is known, such that patients complete 6 months of Lfx (≥6[H]RZE-6Lfx). This cohort study assessed the impact of fluoroquinolones (Fq) on treatment effectiveness, accounting for Hr mutations and degree of phenotypic resistance.MethodsThis was a retrospective cohort study of 626 Hr tuberculosis patients notified in London, 2009–2013. Regimens were described and logistic regression undertaken of the association between regimen and negative regimen-specific outcomes (broadly, death due to tuberculosis, treatment failure or disease recurrence).ResultsOf 594 individuals with regimen information, 330 (55.6%) were treated with (H)RfZE (Rf=rifamycins) and 211 (35.5%) with (H)RfZE-Fq. The median overall treatment period was 11.9 months and median Z duration 2.1 months. In a univariable logistic regression model comparing (H)RfZE with and without Fqs, there was no difference in the odds of a negative regimen-specific outcome (baseline (H)RfZE, cluster-specific odds ratio 1.05 (95% CI 0.60–1.82), p=0.87; cluster NHS trust). Results varied minimally in a multivariable model. This odds ratio dropped (0.57, 95% CI 0.14–2.28) when Hr genotype was included, but this analysis lacked power (p=0.42).ConclusionsIn a high-income setting, we found a 12-month (H)RfZE regimen with a short Z duration to be similarly effective for Hr tuberculosis with or without a Fq. This regimen may result in fewer adverse events than the WHO recommendations.
MicroRNA-138 negatively regulates the hypoxia-inducible factor 1α to suppress melanoma growth and metastasis
Authors: Qiu Haijiang , Chen Fangchao , Chen Minjun 
Published: August 2019

ABSTRACT
Melanoma with rapid progression towards metastasis has become the deadliest form of skin cancer. However, the mechanism of melanoma growth and metastasis is still unclear. Here, we found that miRNA-138 was lowly expressed and hypoxia-inducible factor 1α (HIF1α) was highly expressed in patients’ melanoma tissue compared with the paracancerous tissues, and they had a significant negative correlation (r=−0.877, P&lt;0.001). Patients with miRNA-138low/HIF1αhigh signatures were predominant in late stage III/IV of melanoma. Further, bioinformatic analysis demonstrated that miRNA-138 directly targeted HIF1α. We found that the introduction of pre-miRNA-138 sequences to A375 cells reduced HIF1α mRNA expression and suppressed cell proliferation, migration and invasion. Overexpression of miRNA-138 or inhibition of HIF1α significantly suppressed the growth and metastasis of melanoma in vivo. Our study demonstrates the role and clinical relevance of miRNA-138 and HIF1α in melanoma cell growth and metastasis, providing a novel therapeutic target for suppression of melanoma growth and metastasis.
The impact of city-wide deployment of Wolbachia-carrying mosquitoes on arboviral disease incidence in Medellín and Bello, Colombia: study protocol for an interrupted time-series analysis and a test-negative design study
Authors: Velez Ivan D. , Santacruz Eduardo , Kutcher Simon C. , Duque Sandra L. , Uribe Alexander , Barajas Jovany , Gonzalez Sandra , Patino Ana Cristina , Zuluaga Lina , Martínez Luis , Mejia María Camila , Arbelaez María Patricia , Pulido Henry , Jewell Nicholas P. , O'Neill Scott L. , Simmons Cameron P. , Anders Katherine L. , Tanamas Stephanie K. 
Published: August 2019

Background: Dengue, chikungunya and Zika are viral infections transmitted by Aedes aegypti mosquitoes, and present major public health challenges in tropical regions. Traditional vector control methods have been ineffective at halting disease transmission. The World Mosquito Program has developed a novel approach to arbovirus control using Ae. aegypti stably transfected with the Wolbachia bacterium, which have significantly reduced ability to transmit dengue, Zika and chikungunya in laboratory experiments. Field releases in eight countries have demonstrated Wolbachia establishment in local Ae. aegypti populations. Methods: We describe a pragmatic approach to measuring the epidemiological impact of city-wide Wolbachia deployments in Bello and Medellín, Colombia. First, an interrupted time-series analysis will compare the incidence of dengue, chikungunya and Zika case notifications before and after Wolbachia releases, across the two municipalities. Second, a prospective case-control study using a test-negative design will be conducted in one quadrant of Medellín. Three of the six contiguous release zones in the case-control area were allocated to receive the first Wolbachia deployments in the city and three to be treated last, approximating a parallel two-arm trial for the >12-month period during which Wolbachia exposure remains discordant. Allocation, although non-random, aimed to maximise balance between arms in historical dengue incidence and demographics. Arboviral disease cases and arbovirus-negative controls will be enrolled concurrently from febrile patients presenting to primary care, with case/control status classified retrospectively following laboratory diagnostic testing. Intervention effect is estimated from an aggregate odds ratio comparing Wolbachia-exposure odds among test-positive cases versus test-negative controls. Discussion: The study findings will add to an accumulating body of evidence from global field sites on the efficacy of the Wolbachia method in reducing arboviral disease incidence, and can inform decisions on wider public health implementation of this intervention in the Americas and beyond. Trial registration: ClinicalTrials.gov: NCT03631719. Registered on 15 August 2018.
On the Efficacy of Static Prices for Revenue Management in the Face of Strategic Customers
Authors: Chen Yiwei , Farias Vivek F. , Trichakis Nikolaos 
Published: August 2019

We consider a canonical revenue management (RM) problem wherein a monopolist seller posts prices for multiple products that are for sale over a fixed horizon so as to maximize expected revenues. Products are differentiated and subject to joint capacity constraints. Arriving customers are forward looking and strategize on the timing of their purchase, an empirically confirmed aspect of modern customer behavior. In the event that customers were myopic, foundational work has established that static prices are asymptotically optimal for this problem in the regime where inventory and demand grow large. In stark contrast, for the case where customers are forward looking, available results in mechanism design and dynamic pricing suggest substantially more complicated prescriptions. Notably, these results apply to settings with merely a single product type, and they are also often constrained by restrictive assumptions on customer type. We demonstrate that static prices surprisingly remain asymptotically optimal in the face of strategic customers for a multiproduct setting and for a broad class of customer utility models. For the single-product case, we further show that an optimally set static price guarantees the seller revenues that are within at least 63.2% of that under an optimal dynamic pricing policy, irrespective of regime. For utility models outside the class we consider, we show that static prices need not be asymptotically optimal. Nevertheless, the class of customer utility models we consider is parsimonious, enjoys empirical support, and subsumes many of the models considered for this problem in existing mechanism design research. We allow for multidimensional customer types and for a customer’s disutility from waiting to be positively correlated with his valuation. Therefore, our findings are likely to be robust and provide for a canonical RM problem a simple prescription that is near-optimal across a broad set of modeling assumptions. This paper was accepted by Yinyu Ye, optimization.
DISTRIBUIÇÃO ESPACIAL DE CRIADOUROS DE AEDES AEGYPTI EM JAGUARUANA – CE – BRASIL E SUAS CORRELAÇÕES COM INDICADORES SOCIODEMOGRÁFICOS
Authors: Maia Carlos Vangerre de Almeida , De Lima Gledson Santos , Rocha Alisson Daniel Silva , De Oliveira Estelita Lara , Da Silva Márcia Cristina Freitas , Da Silva Hihara Henrique , Barros Gabriel Douglas Santiago 
Published: August 2019

O Aedes aegypti é originário das selvas africanas, principal responsável pela disseminação de arboviroses (Dengue, Febre amarela, Zika e Chikungunya), capaz de se reproduzir em ambientes naturais ou depósitos artificiais. O controle das arboviroses passa pela capacidade de eliminar os Depósitos Positivos (DPs) para os culicídeos. O objetivo desse trabalho é mapear as áreas de risco para a ocorrência de DPs em três bairros contíguos, em Jaguaruana-CE, referente aos anos 2014 e 2015, mediante análises geoestatísticas, bem como aferir possíveis correlações entre variáveis sociodemográficas, constantes nos 14 setores censitários que se sobrepõem aos bairros e a ocorrência dos DPs, através da Correlação de Spearman, adotando o Intervalo de Confiança menor ou igual a 95%. Os resultados comprovam a existência de uma possível área de risco, bem como, correlação entre a DPs e densidade populacional (ρ = 0,58; p = 0,03) e com a coleta de resíduos sólidos (ρ = -0,53; p = 0,05), coadunando para o entendimento de que o mosquito, por meio da oferta de seres humanos para praticar a hematofagia e existência de depósitos para sua ovipostura, não precisa se deslocar muito. Ou seja, as atuais condições são favoráveis para sua perpetuação na região estudada, cabendo ao poder público local se munir de estratégias para o combate ao culicídeo.
Simulation model of a stop production line: the relationship between financial return and productivity
Authors: Santos Bruno Miranda , Garlet Taís Bisognin , Klein Luciano , Silveira Franco , Rodrigues Paulo Cesar Chagas , Bueno Wagner 
Published: August 2019

Making innovations to become competitive is not always an easy task, and in the industrial sphere, this thinking becomes even more complex. In this sense, proper use in raw material transformation processes becomes very challenging for managers, since improving processes is a condition where more can be done with less. Thus, many organizations seek to develop improvements through existing activities using a variety of techniques that are addressed in the literature, such as value flow mapping, lean production, simulations, among others. Therefore, this article aims to study and apply the computational simulation, through the use of Tecnomatix Plant Simulation © software, to obtain the best relation between financial return and productivity of a upholstery production line. In the methodology of this work was carried out the structural proposition of five scenarios. For the construction of these, a current scenario of the production line was carried out and for each new scenario, operators were added with new tasks to be performed. Although the final results show a better financial return for scenario three, the results obtained in scenario five are significant in terms of productivity indicators, although the cost with extra operators is much higher than in the other scenarios. Thus, it was clear the relevance of applying simulation in the production line, since the model assisted the managers in the decision making.
Vaginal delivery after laparotomic myomectomy during pregnancy
Authors: Garofalo Anna , Petruzzelli Paolo , Chiadò Fiorio Tin Michela , Parisi Silvia , Garofalo Giulia , Viora Elsa 
Published: August 2019

Abstract

Background
Symptomatic myomas during pregnancy are a rare condition that could however turn into an emergency because of torsion, necrosis, growth and compression leading to acute abdomen, potentially threating for pregnancy. Surgeons are usually reluctant to perform myomectomy during pregnancy because of an increased uterine blood flow and volume can give rise to a potential risk for haemorrhagic complications, while uterine manipulation can determine adverse pregnancy outcome. However, in some rare cases surgery is compulsory.

Case presentation
Here, we described a case of a successful laparotomic myomectomy performed during pregnancy at 11 weeks of gestation when an acute abdomen occurred. Surgery was followed by regular obstetrics follow-up ended with a spontaneous vaginal delivery with no pregnancy complications.

Conclusion
Although few case reports are described in literature, other authors have performed a myomectomy during pregnancy, and fewer cases have had a subsequent vaginal delivery, so that nowadays there is no clinical evidence on which to base best practice. This case shows that vaginal delivery after a laparotomic myomectomy performed during pregnancy, in selected cases, can be considered as a feasible option.
Evaluation of the abdominopelvic region using MRI in patients with primary amenorrhea
Authors: Gündoğdu Elif , Emekli Emre , Oğuzman Mehmet , Kebapçı Mahmut 
Published: August 2019

Abstract

Background
This study aimed to evaluate the imaging findings of patients who underwent an abdominal and pelvic magnetic resonance imaging (MRI) due to primary amenorrhea.

Methods
The pelvic and abdominal images of 34 female patients (mean age 15.61 years, range 14–19 years) were retrospectively analyzed by a single radiologist blinded to the clinical and laboratory data of the patients (other than primary amenorrhea) to evaluate the etiology of primary amenorrhea. The anatomy and anomalies of the internal genital organs and other accompanying abdominopelvic anomalies were investigated.

Results
Gonadal dysgenesis was present in 14 patients (41.17%) and Müllerian duct anomalies (MDAs) were present in 20 (58.83%) (Mayer-Rokitansky-Kuster-Hauser [MRKH] syndrome in 13 [65%], distal vaginal obstruction [DVO] findings in five [25%], and obstructed hemivagina and ipsilateral renal anomaly [OHVIRA] syndrome in two [10%]). Seven patients with MRKH (53.84%) were of type 1 and six (46.15%) were of type 2. A total of eight additional anomalies (vertebral and renal) were detected, six in MRKH and two in OHVIRA syndrome cases. Endometrioma and hematosalpinx were observed in one of the five patients with DVO (5%).

Conclusions
Primary amenorrhea is a common symptom that affects both the physical and psychosocial status of individuals. Determination of the underlying etiology is the first step in planning treatment. The evaluation of internal genital organ anomalies involved in the etiology is important for sexual function and fertility. MRI is a non-invasive imaging modality that should be preferred in these cases as it provides detailed data about the anatomy and anomalies of internal genital organs due to its high soft tissue contrast resolution.
Elaboration of low-band-gap π-conjugated systems based on thieno[3,4-b]pyrazines
Authors: Cheminet Nathalie , Nogueira Sandra L. , Benaqqa Oumayma , El Malki Zakaria , Bourass Mohamed , Cassegrain Simon , Hamidi Mohammed , Bouachrine Mohammed , Sotiropoulos Jean Marc , Miqueu Karinne , Jarrosson Thibaut , Niebel Claude , Lère-Porte Jean-Pierre , Serein-Spirau Françoise 
Published: August 2019

Abstract
In order to understand the electronic contribution of the thienopyrazine building block on the electronic properties of π-conjugated systems, small molecules containing thiophene and thienopyrazine moieties are synthesized and jointly studied by theoretical (DFT) and experimental methods (UV-Vis, UPS). Taking advantages of these preliminar attractive results, four low band gap extended structures have been elaborated on the base of Donor-Acceptor-Donor sequences (DAD); these elongated π-conjugated molecules exhibit noticeable electronic and absorption properties spreading from the near UV to NIR regions.
Modeling methods for gravity flow of granular solids in silos
Authors: Golshan Shahab , Zarghami Reza , Saleh Khashayar 
Published: August 2019

Abstract
This paper provides a review on the flow of free-flowing particles inside silos. We have previously reviewed in detail the experimental studies in this field. In the present work, the focus is placed on the theoretical approaches allowing numerical simulation and modeling of these systems. Modeling of granular flow in silos is very significant due to the advantages of modeling compared to experiments. The simulation methods are divided into four main groups: analytical methods, finite element method, discrete element method, and hybrid models. In each section, the most significant researches are reviewed. The drawbacks and advantages of each method are discussed, and the effects of different parameters are reviewed. Finally, the perspective of future work and the main challenges in this area are discussed.
Robustness of Resonant Frequency Test for Strength Estimation of Concrete
Authors: Sajid Sikandar , Chouinard Luc , Carino Nicholas 
Published: August 2019

Abstract
The resonant frequency test (RFT) of molded concrete specimens is a nondestructive test (NDT) method for indirect strength estimation based on the fundamental mode characteristic resonance frequency. In this article, experimental, numerical, and analytical studies were performed to assess the sensitivity of test results to various factors involved in RFT. These factors included vibration modes of the specimen, sensor attachment techniques, contact time of the hammer impact, location of the sensor on the specimen, length to diameter ratio (L/D), and cross-sectional shape of the specimen. Experimental study included concrete specimen preparation in the lab and real-time RFT measurements for robustness of some of the aforementioned factors. Computation models developed using numerical simulations were verified by laboratory test and analytical results. The finite element method–based code, ABAQUS, was employed for computational modeling. Statistical analyses of the experimental results and parametric studies of the computational modeling were used to quantify the effect of the aforementioned factors on uncertainties of strength estimates using RFT measurements. The contact time of the hammer impact and the L/D of the specimen were found to have considerable effect on test results and hence on the concrete strength estimates.