bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring residential energy efficiency measures and distribution of renewable energy generation through sector interactions: a case study in Visby, Sweden
Authors: Amiri Shahnaz , Milić Vlatko 
Published: November 2024

AbstractIncreased use of cogeneration in district heating (DH) systems is important in the pursuit towards a low-carbon society, particularly in light of the ongoing electrification across multiple sectors. Apart from reducing CO2 emissions, cogeneration also contributes to additional income for the DH system owner. Nonetheless, it is important to be aware that the economic and environmental performance of DH systems are directly connected to the energy use within DH networks. This research investigates sector interactions associated with the introduction of a biomass combined heat and power (CHP) and residential energy renovation according to (life cycle cost) LCC optimum and Swedish energy targets, with a focus on CO2 emissions and the system cost of the energy utility company. The study object consists of a DH system in Visby, Sweden, and 920 historic residential building undergoing energy renovation. The results show a profitability of 905–915 MSEK for the DH system with the integration of a CHP. Global CO2 emissions decrease by 32.6–33.1 ktonnes/year, 9.0–9.2 ktonnes/year, and 19.9–20.1 ktonnes/year, for marginal coal-condensing power (limited biofuel), natural gas combined cycle power (limited biofuel), and European average production, respectively. In addition, sensitivity analyses confirm the benefits of cogeneration related to both economics and CO2 emissions based on changes in key parameters of the DH system.
Self-reported visual function and in-depth swept-source optical coherence tomography features of cystoid macular edema in retinitis pigmentosa
Authors: Costa Celso , Nogueira Carlos , Soares Mário , Simão Silvia , Melo Pedro , Silva Rufino , Murta Joaquim , Marques João Pedro 
Published: November 2024

Abstract
Purpose
To evaluate self-reported visual function in retinitis pigmentosa (RP) patients with and without cystoid macular edema (CME) and to explore associations between cystoid spaces (CS), retinal morphometric parameters, and clinical data using swept-source optical coherence tomography (SS-OCT).

Methods
In this cross-sectional case-control study (1:3) conducted at an Inherited Retinal Degenerations referral center in Portugal, RP patients with and without CME (matched for age and gender) completed the Michigan Retinal Degeneration Questionnaire (MRDQ) and underwent SS-OCT. Morphometric analysis, including ellipsoid zone area (EZA), was performed by two independent graders. In the CME group, detailed CS analysis was conducted. Correlations between clinical data - age, gender, best-corrected visual acuity (BCVA) - and MRDQ domains were evaluated.

Results
The study included 23 RP patients with CME (60.87% male, mean age 44.65 ± 13.58 years) and 69 without CME (49.28% male, mean age 47.94 ± 14.39 years). No significant differences were found between groups in almost all MRDQ domains, BCVA, or EZA. Age positively correlated with 4 MRDQ domains in both groups. BCVA negatively correlated with nearly all MRDQ domains. While EZA showed a negative correlation in both groups, it was significant only in RP without CME. In the CME group, centrally located, outer nuclear layer-involving and large CS were associated with worse BCVA but better EZA.

Conclusion
MRDQ responses strongly correlated with clinical parameters. CME does not seem to affect self-reported visual function in RP patients, and CS may not worsen visual function. Thus, aggressive treatment of CME in RP may not be necessary.
Retinal and choroidal microvascular assessment of children receiving recombinant growth hormone therapy
Authors: Omar Ismail , Fadle Yousra Samir , El Bakry Noura M. Ibrahim 
Published: November 2024

Abstract
Background
The purpose of this study is to evaluate the retinal and choroidal microvascular state in children with congenital isolated growth hormone deficiency (IGHD) and determine the effect of recombinant human growth hormone treatment on these structures compared with healthy controls.

Methods
The study included children with IGHD under recombinant human GH treatment as group one and another group of healthy controls. Both groups were examined using optical coherence tomography angiography (OCTA). Data concerning superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC), and retinal thickness were recorded.

Results
The study included two equal groups of 30 individuals. Both groups had no statistically significant differences in age, gender, weight, or spherical equivalent. However, subjects of group II were taller than those of group I (p = 0.011). OCTA images of the SCP, DCP, and CC vessel density revealed statistically non-significant differences between the two groups.

Conclusion
Children receiving recombinant growth hormone therapy showed no changes in the retinal and choroidal microvasculature or macular thickness.

Trial registration number
1094/03/2024 by Minia University Faculty of Medicine Institutional Review Board. Another registration number is UMIN000055654.
Soluble CD206 and CD163 as novel prognostic biomarkers in adult acute myeloid leukemia
Authors: Al-Matari Haifa A. , Mansour Anwar B. , Ibrahim Sherif Abdelaziz , Zaki Nadia El-Sayed , Badr Abeer Mahmoud 
Published: November 2024

Abstract
Background
Despite advances in chemotherapy, the prognosis of adult acute myeloid leukemia (AML) patients remains poor, with a 5-year survival rate below 25%. In the tumor microenvironment of AML, tumor-associated macrophages (TAMs) are very important in the microenvironment of AML tumors because they help leukemic cells to survive, grow and migrate. They also play a key role in how the disease progresses. M2 macrophages highly express both CD206 (mannose receptor, C type I, and CD163 (hemoglobin scavenger receptor), a monocyte/macrophage receptor, as markers for M2 macrophages. Soluble CD206 (sCD206) and CD163 (sCD163) emerge as prognostic players for hematopoietic neoplasms. This study aimed to assess the prognostic potential of sCD206 and sCD163 as serological markers in AML. The study included 60 AML patients and 20 healthy volunteers as controls. The levels of serological markers sCD206 and sCD163 were measured by ELISA, and their prognostic values were evaluated.

Results
Serum levels of sCD206 and sCD163 were statistically significantly (P < 0.001) higher in AML cases than in controls. AML patients were categorized into two subgroups based on the response outcome to induction therapy: 36 patients (60%) had complete response (CR), and the other 24 patients (40%) had refractory disease. Interestingly, based on response outcome, serum levels of sCD206 and sCD163 as well as total leukocytic count (TLC), absolute neutrophils count (ANC) and absolute lymphocyte count (ALC) were significantly higher (all P < 0.001) in refractory group than in CR group. Further, a significant positive correlation of both sCD206 and sCD163 with TLC, ANC and ALC was observed (all P < 0.001).

Conclusion
Levels of sCD206 and sCD163 emerge as promising prognostic biomarkers for AML outcome and progression.
Minimization of algogenic organic matter from cyanobacteria-laden water by electrochemical oxidation: molecular degradation signature of disinfection by-products precursors by electro-oxidation and electro-Fenton
Authors: Aji Angga , Sidik Fahrudin , Lin Jr-Lin 
Published: November 2024

AbstractAlgogenic organic matter (AOM) generated from cyanobacteria-impacted reservoirs poses a significant risk to drinking water. This study aimed to investigate the molecular degradation signature of Microcystis aeruginosa (MA)-derived AOM by electrochemical oxidation and the corresponding disinfection by-product formation potential (DBPFP). Boron-doped diamond (BDD)-based electro-oxidation (EO) and electro-Fenton (EF) were implemented at pH 3 and 10 mA cm−2 within 1 h. The fluorophore of extracellular organic matter (EOM), the mixture of EOM and intracellular organic matter (IOM), were characterized, and their corresponding molecular weight (MW) were fractionated. The results showed that dissolved organic carbon (DOC) degradation efficiency for BDD-EF treatment is superior and maintains DOC attenuation up to 84% for the EOM suspensions alone, while a low degradation efficiency occurs for IOM-EOM mixture. In contrast, BDD-EO exhibits a maximum DOC degradation around 66% for EOM suspensions alone, but DOC reduction is as low as 20% for IOM-EOM mixture. The H2O2 generated by BDD-EO preferentially degrades humic acid-like substances in EOM suspensions, whereas BDD-EF effectively degrades multiple fluorescent AOM by •OH. For IOM-EOM mixture, BDD-EO efficiently decomposes humics, but BDD-EF preferentially minimizes soluble microbial product-like and aromatic protein-like substances. Meanwhile, BDD-EF favors degrading biopolymers, humics, and low-MW substances, while BDD-EO merely degrades partial biopolymers and humic substances. After either EF or EO, specific DBPFP decreases as EOM presents alone where the toxicity of corresponding DBPs is mitigated effectively, instead the increased specific DBPFP appears for IOM-EOM mixture where the toxic potency ([DBP]/LC50) of corresponding DBPs increases. In summary, EO and EF are powerful in attenuating MA-derived DBP precursors of EOM in the absence of IOM, depending on the molecular signature.
Ischemic heart disease awareness in Egypt's aging population: findings from a national cross-sectional study
Authors: Rakab Mohamed Saad , Baklola Mohamed , Elsalakawi Basel Hatem , Zaki Moaz Mohamed , Elsaeidi Mohamed Elhusseini , Fouad Hossam , Walid Belal , Elbaz Abdelrahman , Emara Ali , Ghanem Abdelrahman Sherif , Radwan Nada Mohammed , Abdelmeguid Ahmed Reda , Alkalla Eman Elsayed , Shaheen Rehab Shaheen Bahram 
Published: November 2024

Abstract
Background
Ischemic heart disease (IHD) remains a leading cause of mortality among the elderly population, particularly in low- and middle-income countries like Egypt, where public health infrastructure may struggle to meet the needs of a growing aging population. Awareness of the risk factors and warning signs associated with IHD is critical for early detection and intervention. This study aimed to evaluate the level of awareness and knowledge regarding IHD risk factors and warning signs among elderly individuals in Egypt, focusing on differences between urban and rural populations.

Results
Among 595 participants aged 60 years and above, only 18.7% demonstrated good knowledge of IHD risk factors, whereas 47.2% were categorized as having poor knowledge. In terms of warning signs, 7.2% exhibited good awareness, while 47.9% showed poor awareness. Overall, more than half (51.8%) of the participants were found to have poor knowledge of IHD, and just 15.1% had good overall awareness of both risk factors and warning signs. Urban participants exhibited significantly higher knowledge compared to rural participants (p < 0.05). Educational attainment was a strong predictor of knowledge, with participants holding postgraduate degrees scoring the highest. Economic status also influenced awareness, with those in the excellent category demonstrating significantly higher knowledge (p < 0.05). Occupation had a notable impact, with engineers exhibiting the highest levels of awareness and farmers the lowest. Gender, however, was not a significant factor, with males and females showing similar levels of awareness.

Conclusions
The study reveals a significant knowledge gap concerning IHD risk factors and warning signs among Egypt’s elderly population, particularly in rural areas and among individuals with lower levels of education and economic status. This gap underscores the need for targeted public health campaigns and interventions, particularly in rural regions, to raise awareness and reduce the burden of IHD among Egypt's elderly. Enhanced education and community-based programs could be effective in mitigating the risks associated with poor awareness of IHD.
Disentangling organizational agility from flexibility, adaptability, and versatility: a systematic review
Authors: Desalegn Eskedar Gizat , Guedes Maria João Coelho , Da Silva Gomes Jorge Filipe , Tebeka Shiferaw Mitiku 
Published: November 2024

AbstractOrganizational agility is the ability of an organization to swiftly and efficiently respond to changes in the organization’s environment. However, the literature demonstrates the interchangeability of agility, flexibility, adaptability, and versatility. Therefore, confusion and conceptual overlap persist. As a result, this study aimed to provide further conceptual clarity about organizational agility by synthesizing organizational agility, flexibility, adaptability, and versatility. A systematic review of 40 articles published in business and management-related journals between 1991 and 2022 in ABI/INFORMS, Since Direct, Emerald databases are employed. Findings from thematic analysis and content analysis using Leximancer text mining analysis show that versatility, adaptability, and flexibility are closely connected with their focus on coping with change in the business environment. However, agility is distinct due to its emphasis on organizational ability, capability, and changeability, as well as how it conceptualizes these attributes. This review contributes to developing organizational agility theory and practice by disentangling organizational agility from related concepts. Specifically, it contributes to scientific communication by referring to the same phenomena as organizational agility. Finally, the study concludes by highlighting future research directions.
Vonoprazan-amoxicillin combination therapy for Helicobacter pylori eradication: an umbrella review of meta-analyses
Authors: Syed Saif , Zehra Fatima Tu , Zaman Maham , Karmani Vikash Kumar , Saleem Ayesha , Khalid Momina , Asim Syeda Nimrah , Izhar Sara , Suhagiya Gaurang Hasmukhbhai 
Published: November 2024

Abstract
Background
This umbrella review aims to synthesize evidence from previously conducted meta-analyses and review articles to assess the effects of vonoprazan-amoxicillin (VA) in the management of Helicobacter pylori (Hp).

Methods
While adhering to the PRIOR guidelines, PubMed, Google Scholar, Web of Science, and Scopus were searched from the database inception to May 2024 to identify relevant articles. The outcomes of interest included eradication rate, compliance, and adverse events. The risk ratios for these outcomes were compared across the studies and a corrected covered area (CCA) assessment was performed to determine overlap. Each included review was assessed for its quality and rigor via the AMSTAR-2 tool.

Results
From 13,743 articles identified during the literature search, 4 meta-analyses were included. A significant overlap was noted across studies with a corrected cover area of 20.8%. VA dual therapy outperformed PPI-based therapies in eradication rates (RR: 1.14–1.15, p < 0.05), but showed no significant difference compared to vonoprazan-amoxicillin-clarithromycin (VAC) triple therapy (RR: 0.95–0.97, p > 0.05). Compliance was significantly higher with VA dual therapy versus proton pump inhibitors (PPI)-based therapies (RR: 1.14, p = 0.004), but no significant difference was found between VA dual therapy and VAC therapy. Adverse events were reported inconsistently: one review found a higher likelihood with VA dual therapy versus PPI-based therapies (RR: 1.14, p = 0.0004), while others reported lower risk (RR: 0.59–0.80). VA dual therapy has not shown significant adverse events versus VAC therapy.

Conclusion
VA dual therapy presents as a promising alternative to PPI-based therapies, showcasing better eradication rates and higher compliance. Its performance is comparable to VAC triple therapy, indicating its potential as an effective treatment option for certain conditions.
The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study
Authors: Devinney Michael J. , Spector Andrew R. , Wright Mary C. , Thomas Jake , Avasarala Pallavi , Moretti Eugene W. , Dominguez Jennifer E. , Smith Patrick J. , Whitson Heather E. , Veasey Sigrid C. , Mathew Joseph P. , Berger Miles ,   and the INTUIT Study Investigators
Published: November 2024

BACKGROUND:
Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of postoperative neurocognitive disorder.

METHODS:
In this single-center prospective cohort study, older noncardiac surgery patients aged 60 years and above underwent preoperative home sleep apnea testing, and pre- and postoperative delirium assessments and cognitive testing. Sleep apnea severity was determined using the measured respiratory event index (REI). Global cognitive change from before to 6 weeks (and 1 year) after surgery was used to measure postoperative neurocognitive disorder severity. Postoperative changes in individual cognitive domain performance along with subjective cognitive complaints and/or deficits in instrumental activities of daily living were used to measure postoperative neurocognitive disorder incidence.

RESULTS:
Of 96 subjects who completed home sleep apnea testing, 58 tested positive for sleep apnea. In univariable analyses, sleep apnea severity was not associated with increased postoperative neurocognitive disorder severity at 6 weeks (global cognitive change

; [95% confidence interval [CI], −0.02 to 0.03]; P = .79) or 1-year after surgery (

; [95% CI, −0.02 to 0.03]; P = .70). Adjusting for age, sex, baseline cognition, and surgery duration, sleep apnea severity remained not associated with increased postoperative neurocognitive disorder severity at 6 weeks (

; [95% CI, −0.02 to 0.04]; P = .40) or 1-year after surgery (

; [95% CI, −0.02 to 0.04]; P = .55). In a multivariable analysis, sleep apnea severity was not associated with postoperative neurocognitive disorder (either mild or major) incidence at 6 weeks (odds ratio [OR] = 0.89, [95% CI, 0.59–1.14]; P = .45) or 1-year postoperatively (OR = 1.01, [95% CI, 0.81–1.24]; P = .90). Sleep apnea severity was also not associated with postoperative delirium in univariable analyses (delirium incidence OR = 0.88, [95% CI, 0.59–1.10]; P = .37; delirium severity

; [95% CI, −0.02 to 0.03]; P = .79) or in multivariable analyses (delirium incidence OR = 1.07, [95% CI, 0.81–1.38]; P = .74; delirium severity OR = 0.95, [95% CI, 0.81–1.10]; P = .48).

CONCLUSIONS:
In this older noncardiac surgery cohort, untreated sleep apnea was not associated with increased incidence or severity of postoperative neurocognitive disorder or delirium.
Coming Out in the Parish Hall
Authors: White Heather R. 
Published: November 2024

Abstract
This essay recovers the history of the church that served as New York City’s first gay community center. The parish hall of the Church of the Holy Apostles, an Episcopal congregation located in the Manhattan neighborhood of Chelsea, supplied meeting space for gay and lesbian organizations in the late 1960s and early 1970s, during the movement growth that followed the Stonewall riots of June 1969. This moment’s rise of gay radicalism has been framed as quintessentially secular—fueled by antiestablishment protest and by leading activists’ rejection of religion. This article recontextualizes this secular political emergence by situating it in a parish hall—a nonreligious space by church definition and a religious space by gay activist definition. The aim is not to refute post-Stonewall organizers’ deliberate secularism but to question the notion that religion was absent in this development. To rephrase a well-worn metaphor: religion was not only “in the room” of these activist meetings; religion was the room. Taking a closer look at the parish hall concretizes the shaping influence of American Protestantism on the secular—in this instance, as the very walls, floors, windows, and doorways of the rooms that facilitated queer identity pride.
AMPK associates with and causes fragmentation of the Golgi by phosphorylating the guanine nucleotide exchange factor GBF1
Authors: Freemantle Jordana B. , Towler Mhairi C. , Hudson Emma R. , Macartney Thomas , Zwirek Monika , Liu David J. K. , Pan David A. , Ponnambalam Sreenivasan , Hardie D. Grahame 
Published: November 2024

ABSTRACT
AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular functions in response to changes in energy availability. However, whether AMPK activity is spatially regulated, and the implications for cell function, have been unclear. We now report that AMPK associates with the Golgi, and that its activation by two specific pharmacological activators leads to Golgi fragmentation similar to that caused by the antibiotic Golgicide A, an inhibitor of Golgi-specific Brefeldin A resistance factor-1 (GBF1), a guanine nucleotide exchange factor that targets ADP-ribosylation factor 1 (ARF1). Golgi fragmentation in response to AMPK activators is lost in cells carrying gene knockouts of AMPK-α subunits. AMPK has been previously reported to phosphorylate GBF1 at residue Thr1337, and its activation causes phosphorylation at that residue. Importantly, Golgi disassembly upon AMPK activation is blocked in cells expressing a non-phosphorylatable GBF1-T1337A mutant generated by gene editing. Furthermore, the trafficking of a plasma membrane-targeted protein through the Golgi complex is delayed by AMPK activation. Our findings provide a mechanism to link AMPK activation during cellular energy stress to downregulation of protein trafficking involving the Golgi.
Effects of 24-Hour Diet- or Exercise-Induced Energy Availability Manipulations on Substrate Utilization and Performance
Authors: Smith Ella S. , Kuikman Megan , Weakley Jonathon , Tee Nicolin , McCormick Rachel , Ackerman Kathryn E. , Elliott-Sale Kirsty J. , Stellingwerff Trent , Harris Rachel , McKay Alannah K. A. , Burke Louise M. 
Published: November 2024

ABSTRACT

Purpose
To examine sex-based differences in substrate oxidation, postprandial metabolism, and performance in response to 24-hour manipulations in energy availability (EA), induced by manipulations to energy intake (EI) or exercise energy expenditure (EEE).

Methods
In a Latin Square design, 20 endurance athletes (10 females using monophasic oral contraceptives and 10 males) undertook five trials, each comprising three consecutive days. Day one was a standardized period of high EA; EA was then manipulated on day two; post-intervention testing occurred on day three. Day two EA was low/high/higher EA (LEA/HEA/GEA) at 15/45/75 kcal·kg-1FFM·day-1, with conditions of LEA and HEA separately achieved by manipulations of either EI or EEE (LEA REST/EX vs. HEAREST/EX). On day three, fasted peak fat oxidation during cycling and two-hour postprandial (high carbohydrate and energy meal) metabolism were assessed, alongside several performance tests: Wingate, countermovement jump (CMJ), squat jump (SJ), isometric mid-thigh pull (IMTP), and the Stroop Color and Word Test.

Results
Highest peak fat oxidation occurred under LEA induced by exercise (p < 0.01), with no difference between sexes. Postprandial glucose (p < 0.01) and insulin (p < 0.05) responses were highest across both sexes when LEA was induced by diet. Relative peak and mean power throughout the Wingate, alongside CMJ height did not differ between EA conditions (p > 0.05), while SJ height was lower during GEA than both LEAREST (p = 0.045) and HEAEX (p = 0.016). IMTP peak force and the Stroop effect did not change with altered EA (p > 0.05).

Conclusions
Acute (24-hour) exercise-induced LEA influenced fasted substrate oxidation more than diet-induced LEA, while 24 hours of LEA did not impair strength/power, sprint capacity, or cognitive performance. Finally, the responses to EA manipulations did not differ between sexes.