bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-Cultural Validity: Canadian Norm Values of the Alberta Infant Motor Scale Evaluated for Dutch Infants
Authors: Suir Imke , Boonzaaijer Marike , Nijmolen Petra , Westers Paul , Nuysink Jacqueline 
Published: September 2019

Purpose:
To examine whether the Canadian normative values of the Alberta Infant Motor Scale (AIMS) are appropriate for Dutch infants.

Method:
In a cross-sectional study, 499 infants developing typically (0.5-19 months) were assessed using the AIMS home video method. The scaling method was used for calculating item locations of the Dutch sample, and Welch test to compare Canadian and Dutch raw scores.

Results: The
AIMS items (45 of 58) met the criterion for stable regression to calculate item locations of the Dutch data set and compare these with the Canadian data set. Dutch infants passed 42 of 45 items at an older age. Most monthly age groups of Dutch infants had lower mean AIMS scores.

Conclusion:
The Canadian norms are not appropriate for the Dutch study sample. Dutch infants appear to develop in a similar sequence but at a slower rate. This has implications regarding the clinical use of the AIMS in the Netherlands.
Long non-coding RNA Neat1 regulates adaptive behavioural response to stress in mice
Authors: Kukharsky Michail S. , Ninkina Natalia N. , An Haiyan , Telezhkin Vsevolod , Wei Wenbin , de Meritens Camille Rabesahala , Cooper-Knock Johnathan , Nakagawa Shinichi , Hirose Tetsuro , Buchman Vladimir L. , Shelkovnikova Tatyana A. 
Published: September 2019

AbstractNEAT1 is a highly and ubiquitously expressed long non-coding RNA (lncRNA) which serves as an important regulator of cellular stress response. However, the physiological role of NEAT1 in the central nervous system (CNS) is still poorly understood. In the current study, we addressed this by characterising the CNS function in the Neat1 knockout mouse model (Neat1-/- mice), using a combination of behavioural phenotyping, electrophysiology and expression analysis. RNAscope® in situ hybridisation revealed that in wild-type mice, Neat1 is expressed evenly across the CNS, with high expression in glial cells and low expression in neurons. Loss of Neat1 in mice results in an inadequate reaction to physiological stress manifested as hyperlocomotion and panic escape response. In addition, Neat1-/- mice display deficits in social interaction and rhythmic patterns of activity but retain normal motor function and memory. Neat1-/- mice do not present with neuronal loss, overt neuroinflammation or gross synaptic dysfunction in the brain. However, cultured Neat1-/- neurons are characterised by hyperexcitability and dysregulated calcium homeostasis, and stress-induced neuronal activity is also augmented in Neat1-/- mice in vivo. Gene expression analysis showed that Neat1 may act as a weak positive regulator of multiple genes in the brain. Furthermore, loss of Neat1 affects alternative splicing of genes important for the CNS function and implicated in neurological diseases. Overall, our data suggest that Neat1 is involved in stress signaling in the brain and fine-tunes the CNS functions to enable adaptive behaviour in response to physiological stress.
Deciphering anomalous heterogeneous intracellular transport with neural networks
Authors: Han Daniel S , Korabel Nickolay , Chen Runze , Johnston Mark , Allan Viki J. , Fedotov Sergei , Waigh Thomas A. 
Published: September 2019

AbstractBiological intracellular transport is predominantly heterogeneous in both time and space, exhibiting varying non-Brownian behaviour. Characterisation of this movement through averaging methods over an ensemble of trajectories or over the course of a single trajectory often fails to capture this heterogeneity adequately. Here, we have developed a deep learning feedforward neural network trained on fractional Brownian motion, which provides a novel, accurate and efficient characterization method for resolving heterogeneous behaviour of intracellular transport both in space and time. Importantly, the neural network requires significantly fewer data points compared to established methods, such as mean square displacements, rescaled range analysis and sequential range analysis. This enables robust estimation of Hurst exponents for very short time series data, making possible direct, dynamic segmentation and analysis of experimental tracks of rapidly moving cellular structures such as endosomes and lysosomes. By using this analysis, we were able to interpret anomalous intracellular dynamics as fractional Brownian motion with a stochastic Hurst exponent.
Experimental system and image analysis software for high throughput phenotyping of mycorrhizal growth response inBrachypodium distachyon
Authors: Maviane-Macia Felicia , Ribeyre Camille , Buendia Luis , Gaston Mégane , Khafif Mehdi , Devoilles Fabrice , Peeters Nemo , Lefebvre Benoit 
Published: September 2019

AbstractPlant growth response to Arbuscular Mycorrhizal (AM) fungi is variable and depends on genetic and environment factors that still remain largely unknown. Identification of these factors can be envisaged using high-throughput and accurate plant phenotyping.We setup experimental conditions based on a two-compartment system allowing to measureBrachypodium distachyonmycorhizal growth response (MGR) in an automated phenotyping greenhouse. We developed a new image analysis software“IPSO Phen”to estimate ofB. distachyonaboveground biomass.We found a positive MGR in theB. distachyonBd3-1 genotype inoculated with the AM fungiRhizophagus irregularisonly if nitrogen and phosphorus were added together in the compartment restricted to AM fungi. Using this condition, we found genetic diversity inB. distachyonfor MGR ranging from positive to negative MGR depending on the plant genotype tested.Our result on the interaction between nitrogen and phosphorus for MGR inB. distachyonopens new perspectives about AM functioning. In addition, our open-source software allowing to test and run image analysis parameters on large amount of images generated by automated plant phenotyping facilities, will help to screen large panels of genotypes and environmental conditions to identify the factors controlling the MGR.
Single Cell Spatial Chromatin Analysis of Fixed Immunocytochemically Identified Neuronal Cells
Authors: Lee Jaehee , Lu Youtao , Wang Jinchun , Li Jifen , Fisher Stephen A. , Nordgren C. Erik , Rosario Jean G. , Anderson Stewart A. , Ulyanova Alexandra V. , Brem Steven , Chen H. Isaac , Wolf John A. , Grady M. Sean , Healy Mimi , Kim Junhyong , Eberwine James 
Published: September 2019

AbstractAssays examining the open-chromatin landscape in single cells require isolation of the nucleus, resulting in the loss of spatial/microenvironment information. Here we describe CHEX-seq (CHromatin EXposed) for identifying single-stranded open-chromatin DNA regions in paraformaldehyde-fixed single cells. CHEX-seq uses light-activated DNA probes that binds to single-stranded DNA in open chromatin. In situ laser activation of the annealed probes’ 3’-Lightning Terminator™ in selected cells permits the probe to act as a primer for in situ enzymatic copying of single-stranded DNA that is then sequenced. CHEX-seq is benchmarked with human K562 cells and its utility is demonstrated in dispersed primary mouse and human brain cells, and immunostained cells in mouse brain sections. Further, CHEX-seq queries the openness of mitochondrial DNA in single cells. Evaluation of an individual cell’s chromatin landscape in its tissue context enables “spatial chromatin analysis”.One Sentence SummaryA new method, CHEX-seq (CHromatin eXposed), identifies the open-chromatin landscape in single fixed cells thereby allowing spatial chromatin analysis of selected cells in complex cellular environments.
At the heart of controversies
Authors: Amilien Virginie , Tocco Barbara , Strandbakken Paal 
Published: September 2019

PurposeThe purpose of this paper is to discuss and evaluate the role of hybrid forums as tools to address specific controversies related to sustainable practices in localized agro-food systems (LAFS).Design/methodology/approachIn contrast with other conventional public engagement methods, such as citizen juries, consensus conferences, focus groups or deliberative processes, hybrid forums entail a more dynamic and democratic mechanism to reflect and act together, with the aim of constructing a common project around a defined challenge (Callonet al., 2001, 2009). They can offer an enriching and challenging methodological approach in the context of LAFS, especially in the discussion of controversial issues around food chain sustainability. The authors present here a new generation of hybrid forums: HF 2.0.FindingsHF 2.0. represent both a methodological tool and a real experience of dialogic democracy, two interactive aspects which are closely interlinked and rest upon each other. The authors argue that the attractiveness of HF 2.0. is notable in at least two ways: first, they provide a solid democratic and reflective mechanism to stimulate effective dialogue and knowledge-exchange among different stakeholders; second, they contribute as an important methodological evidence-based tool, which can be used as a launching pad for shaping local action groups and community partnerships’ strategies aimed at fostering local development.Originality/valueThis paper attempts to provide a methodological discussion over the experimental use of HF 2.0. in the context of LAFS and assesses their effectiveness in the co-construction of knowledge. The authors explore their pragmatic validity in addressing controversies over local and sustainable seafood via empirical applications in Norway and the UK.
Leadership in challenging times of academic libraries
Authors: Aslam Mohammad 
Published: September 2019

PurposeThe purpose of this study is to explore the key challenges of academic libraries in times of changing nature of higher education system and how library leaders can manage the challenges when effective leadership is highly required for academic libraries today. As the time is changing, the kinds of challenges that library leaders face have also changed. Author of this study explores the methods and approaches, which are more effective ways of managing challenges in the reshaping environment of academic libraries. At the same time, change has become a permanent part of academic libraries and they need leaders who are able to lead and manage change efficiently, bring theories into practices, find innovative solutions to challenges, creative thinkers, effective communicators, collaborative mindset and self-motivators.Design/methodology/approachThe selective publications have been reviewed to find the best ways to leading changes and managing challenges in academic libraries. The approaches and methods in this study are based on personal experiences of author as director of the university libraries and experiences of library leadership worldwide are conversed.FindingsAcademic libraries are facing similar challenges around the world. The author found that academic library leadership needs innovative skills and competencies, effective communication abilities and a new way of thinking to deal with challenges and create willingness to adapt the changes. Kotter’s leadership manage change model may apply for creating and implementing organizational change in academic libraries.Originality/valueLiterature on this topic is comparatively limited. Consequently, this manuscript adds value to the publications of library and information sciences and offers the literature in the field of leadership challenges and manage change in the academic libraries. It also provides guidelines to academic library leadership universally, and how can leaders work with change effectively.
An examination of chronic ill-health and lifestyle factors among inmates: searching for the healthy immigrant effect in New South Wales Prisons
Authors: Field Courtney , Zovko Alyssa , Bowman Julia 
Published: September 2019

Purpose
The purpose of this paper is to compare the rates of chronic health conditions and lifestyle factors between Australian-born and overseas-born inmates and to uncover predictive relationships between lifestyle factors and health outcomes for both groups.

Design/methodology/approach
Data are presented from a cross-sectional study based on a sample of inmates from correctional sites in New South Wales (NSW). The inclusion of results here was guided by the literature relating to the healthy immigrant effect.

Findings
Results indicate that a higher proportion of Australian-born inmates consumed alcohol at higher levels and were more likely to smoke on a daily or almost daily basis than overseas-born inmates. Australian-born inmates were also more likely than overseas-born inmates to have been diagnosed with cancer, epilepsy or hepatitis C. Physical activity predicted the number of diagnoses for Australian-born inmates while physical activity and smoking frequency predicted the number of diagnoses for overseas-born inmates.

Practical implications
Overseas-born inmates make up a considerable portion of the prison population in NSW. A better understanding of those health and lifestyle factors that distinguish them from Australian-born inmates provides important insight regarding health promotion and the planning of service provision for those providing health care in this space.

Originality/value
Comparison of the health of immigrant and native-born prison inmates has not been undertaken before and promises to provide important information regarding those factors that distinguish a sizeable minority in the prison population.
Influence of non-linear radiation, Joule heating and viscous dissipation on the boundary layer flow of MHD nanofluid flow over a thin moving needle
Authors: Upreti Himanshu , Kumar Manoj 
Published: September 2019

Purpose
The purpose of this paper is to examine the effect of non-linear thermal radiation, Joule heating and viscous dissipation on the mixed convection boundary layer flow of MHD nanofluid flow over a thin moving needle.

Design/methodology/approach
The equations directing the flow are reduced into ODEs by implementing similarity transformation. The Runge–Kutta–Fehlberg method with a shooting technique was implemented.

Findings
Numerical outcomes for the coefficient of skin friction and the rate of heat transfer are tabulated and discussed. Also, the boundary layer thicknesses for flow and temperature fields are addressed with the aid of graphs.

Originality/value
Till now, no numerical study investigated the combined influence of Joule heating, non-linear thermal radiation and viscous dissipation on the mixed convective MHD flow of silver-water nanofluid flow past a thin moving needle. The numerical results for existing work are new and their novelty verified by comparing them with the work published earlier.
Economic impact analysis of the coronary heart disease-attributed health care cost savings and productivity gains from the use of Psyllium
Authors: Shanahan Christopher J. , Gibb Roger D. , McRorie Johnson W. , Brum Jose M. , Ritchey Mary E. 
Published: September 2019

PurposeNumerous randomized clinical studies have shown that psyllium fiber lowers serum cholesterol in patients with hyperlipidemia and is thus recognized by the US Food and Drug Administration (FDA) as a dietary fiber that may help reduce the risk of coronary heart disease (CHD) by lowering cholesterol. The purpose of this paper is to assess the potential economic implications for health-care cost savings and quality of life productivity gains if the cholesterol-lowering effect of psyllium, consumed daily as a fiber supplement, could be applied to a broad at-risk population.Design/methodology/approachA cost-benefit analysis tool was used to examine evidence that the use of psyllium as a cholesterol-lowering agent can reduce overall CHD-attributed medical care service costs in the USA among those at high risk of experiencing disease-related events.FindingsResults of the analysis showed that the potential net annual avoided medical care service costs and annual quality of life productivity gains among US adults 45 and older with low-density lipoprotein (LDL) cholesterol levels = 130 mg/dL could be up to an average of $870m per year from 2013 to 2020 if everyone in the target population used seven grams of soluble fiber from psyllium daily, corresponding to a net benefit-cost ratio of $1.19 savings in annual medical service cost and annual productivity gains per $1 spent on a psyllium regimen.Originality/valueThus, the use of psyllium fiber as a daily supplement could be recommended as a means to help control the risk for potentially costly cardiovascular-related medical events and to maximize the economic potential for an improved quality of life in adults 45 and older with LDL cholesterol levels =130 mg/dL.
European ruling parties’ electoral strategies and overseas enfranchisement policies
Authors: TURCU ANCA , URBATSCH R. 
Published: September 2019

AbstractEmigrants’ ideologies and partisan attitudes may diverge from other voters’: overseas voters are ideologically self‐selected, receive distinctive information about campaigns and have experiences abroad that are likely to shape their political views. Parties, anticipating these emigrant attitudes, can manipulate overseas voting availability to give the vote primarily to their own supporters. Alternatively, parties may expect newly enfranchised voters to provide electoral support in gratitude for the right to vote. To distinguish these separate processes, this project undertakes a case study of Turkey to trace a ruling party's strategic expectations as it makes overseas‐enfranchisement decisions. To see how generalisable these results are, the study further extends to a statistical analysis of differences in vote choice between voters at home and abroad across all 23 European countries that report overseas votes separately, using an original dataset encompassing 121 elections. Both the case study and the statistical analysis suggest that emigrant‐enfranchising parties tend to garner overseas voters’ support in a lasting way. This suggests that overseas enfranchisement most often appears to involve incumbent parties (correctly) expecting long‐term ideological compatibility with their overseas nationals, not simply exchanging the franchise for short‐term, transactional support.
Replens prevents preterm birth by decreasing type I interferon strengthening the cervical epithelial barrier
Authors: Nold Christopher , Jensen Todd , O'Hara Kathleen , Stone Julie , Yellon Steven M. , Vella Anthony T. 
Published: September 2019

AbstractProblemA breakdown of the cervical epithelial barrier has been associated with preterm cervical remodeling. It is unknown if Replens, the vehicle for vaginal progesterone, alters cervical epithelial junctional proteins impacting cervical remodeling and preterm birth.Method of studyE17 CD‐1 pregnant mice received an intrauterine injection of saline or lipopolysaccharide (LPS). Effect of intravaginal Replens given on day E16 and on E17 coincident with LPS was tested. A second experiment determined if an antibody to the interferon receptor (IFNaR) blocked the effects of LPS. Mice were killed after six hours, the preterm birth rate was recorded, and the serum and cervices were collected for analysis. Additionally, the epithelial cell barrier was assessed using an in vitro permeability assay.ResultsReplens decreased the rate of LPS‐induced preterm birth within six hours, from 87.5% to 37.5% (P < .005). LPS + IFNaR antibody decreased the rate of preterm birth or vaginal bleeding compared to LPS + control antibody mice, 43.8% vs 87%, respectively (P < .01). E‐Cadherin in the mouse serum was increased by LPS, an effect mitigated by treatment with Replens (P < .0001) or the IFNaR antibody (P < .01). Replens + LPS decreased the expression of IFN‐β (P < .01). The anti‐IFNaR, as well as Replens, decreased the expression of MMP13 (P < .05) compared to LPS mice. Replens also prevented the LPS‐induced increase in permeability (P < .001).ConclusionReplens prevents preterm birth by decreasing the interferon‐induced upregulation of MMP13 and the degradation of the cell adhesion protein E‐Cadherin. Further studies are needed to determine if Replens can be useful as treatment for preterm birth.
The role of animal welfare values in the rhino horn trade debate
Authors: Brown Abigail A. , Dean Angela J. , Possingham Hugh , Biggs Duan 
Published: September 2019

AbstractThe poaching crisis facing Africa's white rhinoceros is one of the continent's most pressing conservation challenges. The controversial proposal to legalize the international trade in rhino horn as a solution has led to a polarized conservation community. While a legal trade in rhino horn has been explored from an economic perspective, stakeholder values are yet to be adequately considered in addressing the issue. Exploring the role of stakeholder values in the rhino horn trade debate is crucial, as divergent stakeholder values and attitudes influence policy support and acceptability, creating conflict over appropriate management interventions. Using a survey of 285 participants, we show that people with stronger animal welfare values are less supportive of a legal rhino horn trade policy. We also demonstrate that people with stronger animal welfare values are less influenced by information provision, and that biospheric and altruistic value orientations do not significantly influence support for this policy. Our findings highlight the importance of considering stakeholder values when developing conservation actions, particularly concerning discussions about controversial policy actions. These findings can be extended beyond the illegal wildlife trade crisis to other challenges affecting iconic wildlife, such as trophy hunting, other sustainable use initiatives and invasive species management.
Prognostic Significance of Preoperative Systemic Cellular Inflammatory Markers in Gliomas: A Systematic Review and Meta‐Analysis
Authors: Wang Da‐Peng , Kang Kai , Lin Qi , Hai Jian 
Published: September 2019

Glioma is the most common malignant brain tumor and has high lethality. This tumor generated a robust inflammatory response that results in the deterioration of the disease. However, the prognostic role of systemic cellular inflammatory indicators in gliomas remains controversial. This meta‐analysis aimed to assess the prognostic significance of preoperative neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), red cell distribution width (RDW), and prognostic nutritional index (PNI) in patients with gliomas. Databases of PubMed, EMBASE, Web of Science, and The Cochrane Library were systematically searched for all studies published up to January 2019. Study screening and data extraction followed established Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. The Newcastle–Ottawa Scale was used to assess the quality of studies. Eighteen studies containing 3,261 patients were included. The analyses showed an increased NLR or RDW was found to be an independent predictor of worse survival in patients with gliomas (hazard ratio (HR): 1.38; 95% confidence interval (CI): 1.09–1.74; P = 0.008; and HR: 1.40; 95% CI: 1.13–1.74; P = 0.002, respectively). Furthermore, a higher PNI indicates a better overall survival (OS; HR: 0.57; 95% CI: 0.42–0.77; P = 0.0002). For the evaluation of PLR and LMR, none of these variables correlated with OS (P = 0.91 and P = 0.21, respectively). Our meta‐analysis indicates the NLR, RDW, and PNI rather than PLR and LMR are the independent index for predicting the OS of gliomas. Pre‐operative NLR, RDW, and PNI can help to evaluate disease progression, optimize treatment, and follow‐up in patients with gliomas.