bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soybean hulls as a low‐cost biosorbent for removal of methylene blue contaminant
Authors: Cusioli Luís Fernando , Quesada Heloise B. , Baptista Aline T. A. , Gomes Raquel G. , Bergamasco Rosângela 
Published: July 2019

AbstractMethylene blue is a cationic dye used for dyeing cotton, wool, and silk. This dye can cause impacts when reaching water resources due to the reduction of sunlight infiltration, besides the health problems if ingested. Therefore, the complete removal of this contaminant in industrial effluents is indispensable. Currently, soybean hulls residues are used in animal feed supplementation; however, since soybean oil production is large, expressive quantities is discarded in landfills. Thus, the present study aim is to evaluate the adsorption capacity of methylene blue onto soybean hulls as an alternative use of this agroindustrial residue. The material was characterized through morphological and chemical analysis which showed porosity, heterogeneity, and functional groups that favor the adsorption. Due to the mainly negative charge of the surface, the pH did not affect the cationic dye uptake, enabling a wide pH range. After the adsorption studies, the best experimental conditions were at temperatures of 298 K, mass of 0.025 g, and contact time of 180 min, resulting in the maximum adsorption capacity of 169.90 mg g−1. When compared with other low‐cost biosorbent and activated carbons, it can be perceived a potential applicability of soybean hulls in wastewater treatment as an alternative use.
Effect of different irradiance levels on bioelectricity generation from algal biophotovoltaic (BPV) devices
Authors: Thong Cheng‐Han , Phang Siew‐Moi , Ng Fong‐Lee , Periasamy Vengadesh , Ling Tau‐Chuan , Yunus Kamran , Fisher Adrian C. 
Published: July 2019

AbstractRapid population and economic growth in the world have accelerated the search for new sustainable and environment‐friendly energy sources. Power‐producing systems generally add to the carbon load in the environment, contributing to global climate change. In photosynthesis, energy from light splits water molecules into oxygen, protons, and electrons. Algal biophotovoltaic (BPV) platforms were developed to harvest these electrons to generate bioelectricity through algal photosynthesis. Irradiance is one of the most important parameters that determine power output efficiency from algal BPV devices. In this study, the effective range of irradiance levels for power generation from algal BPV devices comprising of suspension and alginate‐immobilized Chlorella cultures on ITO anodes was determined. Immobilized cultures were prepared by entrapping the algal cells in 2% sodium alginate solution. The algal BPV devices were illuminated by four different irradiance levels (30, 90, 150, and 210 µmol photons m−2 s−1). The maximum power density of 0.456 mW m−2 was generated from the prototype algal fuel cell at the irradiance level of 150 µmol photons m−2 s−1. At 210 µmol photons m−2 s−1, low power density was produced due to photoinhibition as indicated by Fv/Fm values generated through PAM fluorometry. In terms of carbon fixation rate, the highest value was recorded in immobilized culture at 217.11 mg CO2 L−1 d−1. The algal biophotovoltaic device is multifunctional and can provide sustainable energy with simultaneous carbon dioxide removal.
Performance comparison of epoxy resins modified with diphenylphosphine oxide and DOPO
Authors: Wei Zhenqian , Gu Xintao , Wu Jun , Wei Min , Yu Qing , Xiujuan Tian , Wang Zhongwei 
Published: July 2019

SummaryBy curing the reaction mixture of diphenylphosphine oxide (DPO) and diglycidyl ether of bisphenol A with 4,4′‐diaminodiphenylsulfone, flame‐retardant epoxy resins (EP/DPO) were prepared. Flame‐retardant epoxy resins modified with 9,10‐dihydro‐9‐oxa‐10‐phosphaphenanthrene‐10‐oxide (DOPO) were similarly prepared (denoted as EP/DOPO). The limiting oxygen index value of pure epoxy resin, EP/DPO–P‐0.9 (with a phosphorus content of 0.9 wt%), and EP/DOPO–P‐0.9 are 23.0, 30.5, and 29.4%, respectively. EP/DPO–P‐0.9 reached a UL‐94 vertical burning test V‐0 rating, while EP/DOPO–P‐0.9 failed. The results of the cone calorimetry test, thermo‐oxidative degradation behavior study, and pyrolysis‐gas chromatography/mass spectrometry analysis indicated that both flame retardants mainly act through the gas‐phase activity mechanism. Together, the results of this study suggest that EP/DPO are high performance resins with good thermal stability, high glass transition temperature, and low water absorptivity for practical applications.
Predicting loan default in peer‐to‐peer lending using narrative data
Authors: Xia Yufei , He Lingyun , Li Yinguo , Liu Nana , Ding Yanlin 
Published: July 2019

AbstractPeer‐to‐peer (P2P) lending is facing severe information asymmetry problems and depends highly on the internal credit scoring system. This paper provides a novel credit scoring model, which forecasts the probability of default for each applicant and guides the lenders' decision‐making in P2P lending. The proposal is expected to improve the existing credit scoring models in P2P lending from two aspects, namely the classifier and the usage of narrative data. We utilize an advanced gradient boosting decision tree technique (i.e., CatBoost) to predict default loans. Moreover, a soft information extraction technique based on keyword clustering is developed to compensate for the insufficient hard credit data. Validated on three real‐world datasets, the experimental results demonstrate that variables extracted from narrative data are powerful features, and the utilization of narrative data significantly improves the predictability relative to solely using hard information. The results of sensitivity analysis reveal that CatBoost outperforms the industry benchmark under different cluster numbers of extracted soft information; meanwhile a small number of clusters (e.g., three) is preferred for consideration of model performance, computational cost, and comprehensibility. We finally facilitate a discussion on practical implication and explanatory considerations.
CD5 expression correlates with inferior survival and enhances the negative effect of p53 overexpression in diffuse large B‐cell lymphoma
Authors: Zhao Peiqi , Li Lanfang , Zhou Shiyong , Qiu Lihua , Qian Zhengzi , Liu Xianming , Meng Bin , Zhang Huilai 
Published: July 2019

AbstractDe novo CD5‐positive diffuse large B‐cell lymphoma (CD5+ DLBCL) is increasingly recognized as a distinct pathologic phenomenon with a specific clinical picture. However, CD5+ DLBCL has not been studied on a large scale in China. In this study, we show that CD5+ DLBCL occurs at a low frequency (9.2%). Comparison of clinical characteristics of CD5+ vs CD5− DLBCL showed that CD5+ DLBCL was more frequently elderly (>60 years) and had B symptoms, high‐performance status, stage III‐IV, an IPI score >2 and bone marrow involvement. Patients with CD5+ DLBCL had tumours with a higher prevalence of BCL‐2 and p53 overexpression than CD5− DLBCL. Patients with CD5+ DLBCL had inferior progression‐free survival (PFS) and overall survival (OS) than did patients with CD5− DLBCL. For CD5+ DLBCL, the patients who were treated with rituximab showed significantly better PFS and OS than those treated without rituximab. However, patients treated with RCHOP showed similar PFS and OS when compared with the group treated with intensive therapy. In addition, patients with p53 and CD5 co‐expression had the worst PFS and OS. In conclusion, CD5+ DLBCL was associated with unfavorable clinicopathologic variables and with inferior survival. CD5+ DLBCL has a high frequency of p53 overexpression, and CD5 augments the negative effect of p53 overexpression in DLBCL.
Ice cover exists: A quick method to delineate groundwater inputs in running waters for cold and temperate regions
Authors: O'Sullivan Antóin M. , Linnansaari Tommi , Curry R. Allen 
Published: July 2019

AbstractGroundwater can be important in regulating stream thermal regimes in cold, temperate regions, and as such, it can be a significant factor for aquatic biota habits and habitats. Groundwater typically remains at a constant temperature through time; that is, it is warmer than surface water in winter and cooler in summer. Further, small tributaries are often dominated by groundwater during low flows of winter and summer. We exploit these thermal patterns to identify and delineate tributary/groundwater inputs along a frozen river (ice‐on) using publically available satellite data, and we tested the findings against airborne, thermal infrared (TIR) data. We utilize a supervised maximum likelihood classification (sMLC) to identify possible groundwater inputs while the river is in a frozen state (kappa coefficient of 96.77 when compared with visually delineated possible groundwater inputs). We then compare sMLC‐identified possible groundwater inputs with TIR‐classified groundwater inputs, which confirmed that there was no statistical difference (χ2 = .78), that is, confirming that groundwater inputs can be delineated in north temperate river systems using available satellite imagery of the system's frozen state. Our results also established the spatial extent and influence of possible groundwater inputs in two seasons. The thermal plumes were longer and narrower in winter; this is likely related to seasonal differences in dispersion regimes. We hypothesize that differences between summer and winter is related to either (a) tributaries that are modulated by shading in summer or (b) aquifer disconnection from the river in winter owing to frozen ground conditions and lack of aquifer recharge. This method of establishing tributary/groundwater inputs and contributions to surface water thermal regimes is relatively simple and can be useful for science and management as long as “ice cover exists”; that is, the system can achieve a frozen state.
RETRACTED: AMP‐kinase inhibitor dorsomorphin reduces the proliferation and migration behavior of colorectal cancer cells by targeting the AKT/mTOR pathway
Authors: Ghanaatgar‐Kasbi Sadaf , Amerizadeh Forouzan , Rahmani Farzad , Hassanian Seyed Mahdi , Khazaei Majid , Ferns Gordon A. , Avan Amir 
Published: July 2019

AbstractColorectal cancer (CRC) is among the leading causes of cancer‐related mortality, despite extensive efforts in the identification of new treatment options. Hence, there is a need for the development of novel agents with therapeutic potential in treatment of CRC. Dorsomorphin has demonstrated antiproliferative activity against different malignancies. Here we have investigated the pharmaceutical potential of dorsomorphin in two‐dimensional and three‐dimensional cell‐culture models of CRC. The antiproliferative, antimigratory, apoptotic activity and effect of this agent on cell cycle was evaluated by 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay, wound healing assay, and flow cytometry, respectively, while the expression of genes involved in Wnt/Pi3K pathways was assessed at mRNA and/or proteins by reverse transcription polymerase chain reaction (RT‐PCR) or western blot. Dorsomorphin inhibited CRC cell growth by modulating the cyclinD1, surviving and p‐Akt. This agent was able to reduce the migratory behaviors of CRC cells, compared to control cells, through perturbation of E‐cadherin. Also our data showed that dorsomorphin enhanced the percentage of the cells in sub‐G1 and induced apoptosis in both late/early stages, as detected by annexin V. Also the regulatory effect of dorsomorphin on oxidant/antioxidant balance was assessed by cellular reactive oxygen species (ROS) generation. In particular, these data showed that dorsomorphin markedly increased the ROS production in CRC cells. Our finding demonstrated that dorsomorphin antagonizes cell growth and migration, through perturbation of Akt/mTOR/Wnt pathways in CRC, supporting further studies on the therapeutic potential of this novel anticancer agent in treatment of CRC.
How‐to guide for effectively performing and coordinating multicenter observational research as a clinical pharmacist
Authors: Hammond Drayton A. , Rech Megan A. 
Published: July 2019

AbstractWhile single‐center research serves multiple purposes for the provision of patient care and identification of testable hypotheses, the importance of multicenter research is well established. The purpose of this “how‐to” guide is to assist pharmacists with the various steps in performing and coordinating multicenter, observational research. The steps that are reviewed include identifying a precise and appropriate research question; determining the expected final products or deliverables from the project and the timeline needed to satisfactorily achieve each step in the process toward these deliverables; establishing the research team structure and recognition of project contributions; navigating the institutional review board approval and data sharing and storage processes; collecting, cleaning, and analyzing data; evaluating additional project management considerations; avoiding and resolving pitfalls of multicenter research; and wrapping up the project. Resources are provided to encourage and support pharmacist principal investigators in their research efforts.
Decellularized liver transplant could be recellularized in rat partial hepatectomy model
Authors: Naeem Erfani M. , Sajad Daneshi , Talaei‐Khozani Tahereh , Khajeh Sahar , Azarpira Negar , Alaei Sanaz , Tanideh Nader , Reza Tabandeh M. , Razban Vahid 
Published: July 2019

AbstractIn situ recellularization of the liver decellularized scaffold is a potential therapeutic alternative for liver transplantation. We aimed to develop an in situ procedure for recellularization of the rat liver using sodium lauryl ether sulfate (SLES) compared with Triton X‐100/SDS. Rat liver specimens were rinsed with PBS, decellularized with either Triton X‐100/SDS or SLES, and finally rinsed by distilled water. The efficiency of decellularized liver scaffolds was evaluated by histological, confocal Raman microscopy, histochemical staining, and DNA quantification assessments. Finally, in vivo studies were done to assess the biocompatibility of the liver scaffold by serum biochemical parameters and the recellularization capacity by histological and immunohistochemistry staining. Findings confirmed the preservation of extracellular matrix (ECM) components such as reticular, collagen, glycosaminoglycans, and neutral carbohydrates in both Triton X‐100/SDS‐ and SLES‐treated livers. Hoechst, feulgen, Hematoxylin and eosin, and DNA quantification assessments confirmed complete genetic content removal. The serological parameters showed no adverse impact on the liver functions. Transplantation of SLES‐treated cell‐free decellularized liver showed extensive neovascularization along with migration of the fibrocytes and adipocytes and some immune cells. Also, immunohistochemical staining showed that the oval cells, stellate cells, cholangiocytes and hepatocytes invaded extensively into the graft. It is concluded that SLES can be considered as a promising alternative in the liver decellularization process, and the transplanted decellularized liver can appropriately be revascularized and regenerated.
Prolonged Effect of Zoledronic Acid on Bone Mineral Density and Turnover in HIV-Infected Adults on Tenofovir: A Randomized, Open-Label Study
Authors: Carr Andrew , Kerr Stephen J , Richardson Robyn , Ebeling Peter , Pocock Nicholas , Rojas Jhon , Martinez Esteban , Hoy Jennifer ,   ZEST study Investigators
Published: July 2019

ABSTRACT
Zoledronic acid (ZOL) 5 mg annually was more effective than tenofovir disoproxil fumarate (TDF) switching at increasing bone mineral density (BMD) over 24 months in HIV-infected, osteopenic adults. To determine whether the effects of ZOL would persist without further infusions, we compared changes in left hip and spine BMD over 36 months in participants randomized to ZOL 5 mg at baseline and month 12 (and to continue TDF) or to switch TDF (without receiving ZOL). We also compared changes in the plasma bone turnover markers (BTMs) C-terminal telopeptide of type 1 collagen (CTX; bone resorption), and procollagen type 1 N propeptide (P1NP; bone formation) and determined whether CTX and P1NP changes at month 3 predicted BMD changes at month 36. Changes were compared in the per-protocol populations, which included 32 (74%) of 43 participants randomized to ZOL and 37 (88%) of 42 participants who switched TDF. Despite not receiving ZOL after month 12, mean hip and spine BMD change from baseline were stable and remained greater with ZOL at month 36 than with TDF switching (spine: 7.5% versus 2.7%, mean difference 4.7%, p &lt; 0.001; hip: 5.5% versus 1.5%, mean difference 4.0%, p &lt; 0.001). CTX and P1NP levels declined in both groups but significantly more with ZOL. Only percent changes in P1NP at month 3 correlated inversely with BMD changes at month 36 (spine: rho = −0.442, p &lt; 0.001; hip: rho = −0.373, p = 0.002). Two infusions of ZOL (in the presence of ongoing TDF) yielded sustained BMD increases through month 36 that remained greater than with TDF switching. © 2019 American Society for Bone and Mineral Research.
Et3N‐Prompted Efficient Synthesis of Anthracenyl Pyrazolines and Their Cytotoxicity Evaluation against Cancer Cell Lines
Authors: Merry Thechano , Maddela Prabhakar , Devaraya Kiran , Kondapi Anand K. , Pradeep Chullikkattil P. 
Published: July 2019

A series of anthracenyl pyrazoline derivatives (3a–o) were synthesized with an aim to evaluate their in vitro anticancer activities. Anthracenyl pyrazoline compounds were prepared by the reaction between various anthracenyl chalcones (1a–o) and hydrazine hydrate (2). The reactions were carried out under reflux in the presence of triethylamine and ethanol for 24 h, and the obtained yields were from good to excellent (90–97%). The structure of each compound is well characterized by IR, 1H‐NMR, 13C‐NMR, elemental analyses, and mass spectroscopic technics, and the molecular structures of compounds 3d and 3e were solved by single‐crystal X‐ray crystallographic methods. The newly synthesized compounds (3a–o) were evaluated for their in vitro cytotoxic studies against four human cancer cell lines MCF‐7 (breast cancer cell lines), SK‐N‐SH (neuroblastoma cancer cell lines), HeLa (cervical cancer cell lines), and HepG2 (liver cancer cell lines), and the screening results show strong cytotoxic effects for most of the synthesized compounds against the three cell lines except SK‐N‐SH cells. Notably, compounds 3a, 3j, 3l, 3m, 3n, and 3o showed a highly potential activity against HeLa cells (IC50: 0.22, 0.3, 0.3, 0.10, 0.25, and 0.25 μM), while compounds 3i, 3k, 3l, and 3m showed a significant cytotoxic activity in HepG2 cells (IC50: 0.22, 0.44, 0.40, and 0.22 μM), whereas compounds 3a, 3b, 3d, and 3e exhibit a promising cytotoxicity against MCF‐7 cells (IC50: 0.73, 0.495, 0.493, and 0.66 μM).
Synthesis and Antifungal Activity of Substituted 2‐Aryl Benzimidazoles Derivatives
Authors: Huang Daye , Qiu Fang , Zhang Zhigang , Shi Liqiao , Cao Chunxia , Ke Shaoyong 
Published: July 2019

Benzimidazole fungicides were among the early systemic fungicides developed and used for controlling a wide variety of plant diseases. During the course of our screening process for active compounds, two 2‐aryl benzimidazoles derivatives bearing sulfoxide group (6b and 6c) have been demonstrated to exhibit good inhibition activity against high‐resistant isolate of Botrytis cinerea compared with carbendazim, and the inhibition rates are up to 46.67% and 51.11% at the concentration of 10 μg/mL, which might be considered as the active framework for the discovery of novel fungicide to high‐resistant isolate of B. cinerea.
Normal values of native T1 and T2 relaxation times on 3T cardiac MR in a healthy pediatric population aged 9–18 years
Authors: Barczuk‐Falęcka Marzena , Małek Łukasz A. , Werys Konrad , Roik Danuta , Adamus Kalina , Brzewski Michał 
Published: July 2019

BackgroundNative myocardial T1 and T2 relaxation times are diagnostic tools used in clinical practice for adult and pediatric populations. Use of a mapping technique requires accurate knowledge of normal ranges in healthy patients, which is lacking in pediatric populations.PurposeTo establish normal values for native T1 and T2 mapping in healthy pediatric subjects of different ages and sex.Study TypeProspective.PopulationThirty‐eight healthy children (9–18 years; mean age 14.0 ± 2.7).Field StrengthCardiac MR with a 3T scanner. T1 and T2 mapping using MyoMaps software.AssessmentT1 and T2 relaxation times were calculated from a 0.7–1.0 cm2 region of interest placed at the mid‐ventricular short‐axis slice in the interventricular septum by two observers. Inter‐ and intraobserver variability was assessed.Statistical TestsThe Student's t‐test or the Mann–Whitney test for unpaired samples was applied to compare one continuous variable between two category groups. One‐way analysis of variance (ANOVA) or a Kruskal–Wallis test was applied to compare one continuous variable between three category groups. Correlation between two continuous variables was assessed with a Pearson or Spearman test.ResultsThe mean native T1 relaxation time was 1223 ± 29 msec and T2 relaxation time was 43 ± 4.5 msec. There was no correlation between T1/T2 values and age or body surface area (for T1 P = 0.94 and 0.90 and for T2 P = 0.19 and 0.64, respectively). There was weak correlation between T1 values and body mass index (BMI) (r = 0.448, P = 0.005). T2 values were significantly higher in females compared with males (44.6 ± 4.2 vs. 40.4 ± 3.8 msec, P = 0.002). We found a significant rise of T2 relaxation time in the pubertal period (age 13–15 years) comparing to prepubertal (age 9–12 years). Inter‐ and intraobserver agreement of T1 (r = 0.93; r = 0.99) and T2 (r = 0.96; r = 0.95) were high.Data ConclusionWe report normal values of native T1 and T2 relaxation times obtained with Myomaps software for 3T cardiac MR in a healthy pediatric population.Level of Evidence: 2Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2020;51:912–918.
Revisiting the relationships of 2D:4D with androgen receptor (AR) gene and current testosterone levels: Replication study and meta‐analyses
Authors: zhang Kejin , Yang Xing , zhang Mengfei , Wang Chunlan , Fang Pengpeng , Xue Mengying , Zhao Jing , Gao Xiaocai , Pan Ruliang , Gong Pingyuan 
Published: July 2019

AbstractThe relationships of digit ratio (2D:4D) with the length of AR (CAG)n, and testosterone levels from saliva and blood have been extensively debated over the years. This research including three studies further clarifies such controversies. To do so, we re‐examined the relationships between the length of AR (CAG)n, 2D:4D, and current testosterone levels, through replication study and meta‐analysis for each study. The results indicate: (a) the length of AR (CAG)n is not significantly associated with 2D:4D; (b) current testosterone levels are not significantly associated with the ratio; and (c) the length is not significantly associated with testosterone levels. Thus, AR (CAG)n and current testosterone levels are not significantly related to 2D:4D at individual level.