bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract P6-12-22: Sexual health in long-term breast cancer survivors
Authors: Soldera SV , Ennis M , Lohmann AE , Goodwin PJ 
Published: February 2018

Abstract
Background Significant sexual dysfunction is reported in women with breast cancer (BC) in the years following diagnosis. It is unclear whether symptoms persist over time in BC survivors (BCS) as long-term data compared to healthy controls is lacking. We compared sexual functioning in long-term BCS to controls and explored the impact of adjuvant therapy on sexual health. Methods A cohort of women with localized BC recruited from 1989 to 1996 was prospectively followed as previously described. BCS without recurrence and controls without BC were contacted between 2005 and 2007 and answered self-reported quality of life questionnaires. Sexual health was measured with the Sexual Activity Questionnaire (SAQ). Vasomotor, gynecological and bladder symptoms were scored using the Menopausal Symptom Scale (scale ranges 0-4) based on the Breast Cancer Prevention Trial Symptom Checklist. Regression analysis was used to compare groups, with and without adjustment for age (quadratic) and menopausal status. P values &lt;0.05 were considered significant. Results 248 of 285 BCS and 159 of 167 controls completed the SAQ. The median time from diagnosis of BCS was 12.5 years. BCS were slightly older (61.9 vs 59.1 years, p=0.0004) and somewhat more likely to be post-menopausal (94.4 vs 85.5%, p=0.0025) than controls. Overall, fewer BCS were sexually active than controls (45.2 vs 59.7%, p=0.0041). This difference was no longer significant when adjusted for age and menopausal status (odds ratio 0.68, p=0.075). In those sexually active, no significant differences were noted on the SAQ Pleasure and Discomfort scales.Differences in adjuvant treatment were not significantly associated with being sexually active or the SAQ subscales. BCS scored higher (worse) on the gynecological and bladder symptom scale than controls (0.66 vs 0.43, p=0.0036, adjusted difference 0.24, p=0.0029; 0.60 vs 0.41, p=0.02, adjusted difference 0.18, p=0.029 respectively), but no difference was seen in vasomotor scores. Gynecological symptom scores were greatest in BCS who received adjuvant chemotherapy. Conclusion Despite more frequent long-term gynecological and bladder symptoms, sexual health is similar in BCS and controls. Adjuvant chemotherapy is associated with persistent gynecological symptoms and interventions aimed at improving these could improve quality of life.
Citation Format: Soldera SV, Ennis M, Lohmann AE, Goodwin PJ. Sexual health in long-term breast cancer survivors [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P6-12-22.
Abstract P6-15-03: Outcome after neoadjuvant chemotherapy in elderly breast cancer patients – a pooled analysis of individual patient data from eight prospectively randomized controlled trials
Authors: von Waldenfels G , Loibl S , Furlanetto J , Anna M , Lederer B , Denkert C , Hanusch C , Huober J , Jackisch C , Kümmel S , von Minckwitz G , Schneeweiss A , Untch M , Rhiem K , Fasching PA , Blohmer JU 
Published: February 2018

Abstract
Introduction: Recent studies showed the high and independent impact of age (&lt;40 years) on pathologic complete remission (pCR) and prognosis for patients undergoing neoadjuvant chemotherapy (NACT). Some physicians might not consider elderly patients (&gt;65 years) for NACT due to poor prognosis or higher toxicity. The aim of this analysis is to help selecting appropriately elderly women who would benefit from NACT. Secondly, survival parameters will be investigated in several clinical and histological subgroups.
Methods: From 1998 to 2010, eight prospectively randomized German Breast Group (GBG) trials of anthracycline- and taxane-based NACT were performed and analyzed in this study.
Results: Compared to the overall average, women older than 65 years had significant larger tumors and more overall lymph node involvement. Also, compared to patients younger than 51 years, they had more lobular invasive tumors. Histologically, they had more G2 tumors, more estrogen-receptor positive tumors. PCR (ypT0 ypN0) was strongly associated with age: &gt;65y: 11.7%; 51-65y: 14.1%; 40-50y: 17.3%; &lt;40y: 20.9%. The multivariable logistic regression analysis of clinical parameters showed that young age, clinical stage T4, invasive ductal cancer and poor differentiated breast cancer are predictive for high pCR. The multivariate analyses of molecular subgroups also showed that age &gt;65years is a predictor of significant (p&lt;0.05) lower pCR in TNBC and HR positive/HER2- breast cancers. Nonetheless, in this cohort, HER2+ patients showed pCR rates as high - and for HR+/HER2+ even higher - pCR rates compared to younger patients.
Discussion: This study underlines the unfavorable impact of higher age on pCR, but it shows nevertheless a realistic chance for pCR if NACT is applied - especially for HER2+ patients. Furthermore, elderly patients in this analysis with non-TNBC have a good prognosis (comparable to younger patients) regarding OS, even if they do not have pCR.
Citation Format: von Waldenfels G, Loibl S, Furlanetto J, Anna M, Lederer B, Denkert C, Hanusch C, Huober J, Jackisch C, Kümmel S, von Minckwitz G, Schneeweiss A, Untch M, Rhiem K, Fasching PA, Blohmer JU. Outcome after neoadjuvant chemotherapy in elderly breast cancer patients – a pooled analysis of individual patient data from eight prospectively randomized controlled trials [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P6-15-03.
Abstract P6-15-07: Not presented
Authors: Somlo G , Waisman J , Yuan Y , Li M , Kruper L , Jones V , Treece T , Frankel P , Yim J , Tumyan L , Schmolze D , Menghi F , Liu ET , Hurria A , Yeon C , Mortimer J 
Published: February 2018

Abstract
This abstract was not presented at the symposium.
Abstract PD2-12: Molecular imaging for early identification of patients who benefit from palbociclib in addition to letrozole
Authors: Venema CM , de Vries EFJ , Glaudemans AWJM , Hospers GAP , Schröder CP 
Published: February 2018

Abstract
Palbociclib plus letrozole has improved both progression free survival and overall response rate in metastatic breast cancer (MBC) patients. For response to palbociclib, the best biomarker is ER expression. 16α-[18F]Fluoro-17β-estradiol (FES) -PET allows whole body ER level assessment, and provides insight in the heterogeneity of ER expression throughout the body. We hypothesized that lesions with low uptake on FES-PET are unlikely to respond to letrozole plus palbociclib. METHODS: Post-menopausal women with ER positive MBC were eligible for this pilot study. All patients were staged with fludeoxyglucose (FDG)-PET and CT scan, and in addition a FES-PET was performed at baseline. After 8 weeks treatment an FDG-PET/CT was used for response evaluation. The primary endpoint was the relation between standard uptake value (SUV) per lesion on FES-PET to response, as measured by RECIST 1.1 criteria in case of measurable disease. In case of non-measurable bone lesions, progression was defined as an increase in SUV on FDG-PET of more than 30% per lesion compared to baseline (based on PERCIST). RESULTS: 15 patients were included of which 14 were evaluable for primary endpoint. Mean age was 50 years (range 35-76). Median number of prior therapies was 1. A total of 280 lesions were detected on conventional imaging of which 50 showed low uptake (SUV&lt;1.5) on FES-PET. 29/50 low uptake lesions showed progression based on diagnostic CT (n=9) or FDG PET (n=20). In contrast, 28/230 FES positive lesions showed progression.
ResponseStable diseaseProgression FES uptake &gt;1.51089428230FES uptake &lt;1.57142950 11510857280
DISCUSSION: this pilot trial indicates negative predictive value of low FES uptake for response to letrozol plus palbociclib in ER positive MBC. The FES-PET may therefore be a biomarker for response for this combination treatment. This will have to be explored further in future clinical trials.
Citation Format: Venema CM, de Vries EFJ, Glaudemans AWJM, Hospers GAP, Schröder CP. Molecular imaging for early identification of patients who benefit from palbociclib in addition to letrozole [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr PD2-12.
Lipid-Lowering Therapy With Ezetimibe Decreases Spontaneous Atherothrombotic Occlusions in a Rabbit Model of Plaque Erosion
Authors: Honda Katsuya , Matoba Tetsuya , Antoku Yoshibumi , Koga Jun-ichiro , Ichi Ikuyo , Nakano Kaku , Tsutsui Hiroyuki , Egashira Kensuke 
Published: February 2018

Objective—
Plaque erosion is increasing its importance as one of the mechanisms of acute coronary syndromes in this statin era. However, the clinical efficacy of currently used lipid-lowering agents in the prevention of thrombotic complications associated with plaque erosion has not been clarified. Therefore, we examined the therapeutic effects of ezetimibe or rosuvastatin monotherapy on spontaneous atherothrombotic occlusion.

Approach and Results—
Femoral arteries of Japanese white rabbits, fed a high-cholesterol diet, were injured by balloon catheter, and then angiotensin II was continuously administrated. In 94% of these arteries, spontaneous thrombotic occlusions were observed after 5 weeks (median) of balloon injury. Histochemical analyses indicated that the injured arteries had similar pathological features to human plaque erosions; (1) spontaneous thrombotic occlusion, (2) lack of endothelial cells, and (3) tissue factor expression in vascular smooth muscle cells. Ezetimibe (1.0 mg/kg per day), but not rosuvastatin (0.6 mg/kg per day), significantly decreased thrombotic occlusion of arteries accompanied with accelerated re-endothelialization and the decreases of serum oxysterols despite the comparable on-treatment serum cholesterol levels. The 7-ketocholesterol inhibited the migration of human umbilical vein endothelial cells. Both 7-ketocholesterol and 27-hydroxycholesterol increased tissue factor expression in cultured rat vascular smooth muscle cells. Tissue factor expression was also induced by serum from vehicle- or rosuvastatin-treated rabbits, but the induction was attenuated with serum from ezetimibe-treated rabbits.

Conclusions—
We have established a novel rabbit model of spontaneous atherothromobotic occlusion without plaque rupture that is feasible to test the therapeutic effects of various pharmacotherapies. Ezetimibe may decrease atherothrombotic complications after superficial plaque erosion by reducing serum oxysterols.
Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers
Authors: Poulsen Lars la Cour , Edelmann Reidunn Jetne , Krüger Stig , Diéguez-Hurtado Rodrigo , Shah Akshay , Stav-Noraas Tor Espen , Renzi Anastasia , Szymanska Monika , Wang Junbai , Ehling Manuel , Benedito Rui , Kasprzycka Monika , Bækkevold Espen , Sundnes Olav , Midwood Kim S. , Scott Helge , Collas Philippe , Siebel Christian W. , Adams Ralf H. , Haraldsen Guttorm , Sundlisæter Eirik , Hol Johanna 
Published: February 2018

Objective—
Endothelial upregulation of adhesion molecules serves to recruit leukocytes to inflammatory sites and appears to be promoted by NOTCH1; however, current models based on interactions between active NOTCH1 and NF-κB components cannot explain the transcriptional selectivity exerted by NOTCH1 in this context.

Approach and Results—
Observing that Cre/Lox-induced conditional mutations of endothelial Notch modulated inflammation in murine contact hypersensitivity, we found that IL (interleukin)-1β stimulation induced rapid recruitment of RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A) to genomic sites occupied by NOTCH1-RBPJ (recombination signal-binding protein for immunoglobulin kappa J region) and that NOTCH1 knockdown reduced histone H3K27 acetylation at a subset of NF-κB–directed inflammatory enhancers.

Conclusions—
Our findings reveal that NOTCH1 signaling supports the expression of a subset of inflammatory genes at the enhancer level and demonstrate how key signaling pathways converge on chromatin to coordinate the transition to an infla mmatory endothelial phenotype.
RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis
Authors: Cui Xiao-Bing , Luan Jun-Na , Dong Kun , Chen Sisi , Wang Yongyi , Watford Wendy T. , Chen Shi-You 
Published: February 2018

Objective—
The objective of this study is to determine the role and underlying mechanisms of RGC-32 (response gene to complement 32 protein) in atherogenesis.

Approach and Results—

RGC-32 was mainly expressed in endothelial cells of atherosclerotic lesions in both ApoE
−/−
(apolipoprotein E deficient) mice and human patients.
Rgc
-32 deficiency (
Rgc32
−/−
) attenuated the high-fat diet–induced and spontaneously developed atherosclerotic lesions in ApoE
−/−
mice without affecting serum cholesterol concentration.
Rgc32
−/−
seemed to decrease the macrophage content without altering collagen and smooth muscle contents or lesional macrophage proliferation in the lesions. Transplantation of WT (wild type) mouse bone marrow to lethally irradiated
Rgc32
−/−
mice did not alter
Rgc32
−/−
-caused reduction of lesion formation and macrophage accumulation, suggesting that RGC-32 in resident vascular cells, but not the macrophages, plays a critical role in the atherogenesis. Of importance,
Rgc32
−/−
decreased the expression of ICAM-1 (intercellular adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule-1) in endothelial cells both in vivo and in vitro, resulting in a decrease in TNF-α (tumor necrosis factor-α)–induced monocyte–endothelial cell interaction. Mechanistically, RGC-32 mediated the ICAM-1 and VCAM-1 expression, at least partially, through NF (nuclear factor)-κB signaling pathway. RGC-32 directly interacted with NF-κB and facilitated its nuclear translocation and enhanced TNF-α–induced NF-κB binding to ICAM-1 and VCAM-1 promoters.

Conclusions—
RGC-32 mediates atherogenesis by facilitating monocyte–endothelial cell interaction via the induction of endothelial ICAM-1 and VCAM-1 expression, at least partially, through NF-κB signaling pathway.
Endothelial Cell Autonomous Role of Akt1
Authors: Lee Monica Y. , Gamez-Mendez Ana , Zhang Jiasheng , Zhuang Zhenwu , Vinyard David J. , Kraehling Jan , Velazquez Heino , Brudvig Gary W. , Kyriakides Themis R. , Simons Michael , Sessa William C. 
Published: February 2018

Objective—
The importance of PI3K/Akt signaling in the vasculature has been demonstrated in several models, as global loss of Akt1 results in impaired postnatal ischemia- and VEGF-induced angiogenesis. The ubiquitous expression of Akt1, however, raises the possibility of cell-type–dependent Akt1-driven actions, thereby necessitating tissue-specific characterization.

Approach and Results—
Herein, we used an inducible, endothelial-specific Akt1-deleted adult mouse model (Akt1iECKO) to characterize the endothelial cell autonomous functions of Akt1 in the vascular system. Endothelial-targeted ablation of Akt1 reduces eNOS (endothelial nitric oxide synthase) phosphorylation and promotes both increased vascular contractility in isolated vessels and elevated diastolic blood pressures throughout the diurnal cycle in vivo. Furthermore, Akt1iECKO mice subject to the hindlimb ischemia model display impaired blood flow and decreased arteriogenesis.

Conclusions—
Endothelial Akt1 signaling is necessary for ischemic resolution post-injury and likely reflects the consequence of NO insufficiency critical for vascular repair.
Disharmonious Patterns of Heterotaxy and Isomerism
Authors: Yim Deane , Nagata Hazumu , Lam Christopher Z. , Grosse-Wortmann Lars , Seed Mike , Jaeggi Edgar , Yoo Shi-Joon 
Published: February 2018

Background—
It is advocated that heterotaxy should be segregated into right or left isomerism according to atrial appendage morphology. However, atrial situs determination is often based on the pattern of associated findings rather than on atrial morphology itself, which can be difficult to define. The objective was to assess how often concordant patterns of isomerism classified by atrial appendage morphology, bronchopulmonary pattern, and splenic status are breached using cardiac magnetic resonance or computed tomography. The secondary objective was to determine the feasibility of defining atrial appendage morphology using cardiac magnetic resonance or computed tomography.

Methods and Results—
Retrospective review of 114 pediatric patients (median, 2.4 years; range, 1 day–17.9 years) with heterotaxy who underwent cardiac magnetic resonance or computed tomography was performed to evaluate atrial appendage, bronchopulmonary, and visceral organ arrangements. Atrial appendage and splenic anatomy were not definable in 17 of 114 (15%) and 4 of 114 (3.5%) patients, respectively. In the remaining 93 patients, 39% had classic right isomerism (bilateral right atrial appendages, right bronchopulmonary pattern, and asplenia) and 40% had classic left isomerism (bilateral left atrial appendages, left bronchopulmonary pattern, and polysplenia). Classic pattern of isomerism was breached in 20 of 93 (21.5%) patients: 13 (65%) displayed incongruent abdominal situs, 5 (25%) incongruent bronchial situs, 1 (5%) had discrepant appendage morphology, and 1 (5%) incongruent situs at all levels.

Conclusions—
Atrial appendage morphology is difficult to assess and not always indicative of bronchopulmonary or abdominal situs. Discordance between bronchopulmonary branching, atrial appendage arrangement, and splenic status was identified in >20% patients with heterotaxy. Independent description of each organ system is required when arrangements are disharmonious among different organ systems.
Retroperitoneal Hemorrhage After Percutaneous Coronary Intervention
Authors: Kwok Chun Shing , Kontopantelis Evangelos , Kinnaird Tim , Potts Jessica , Rashid Muhammad , Shoaib Ahmad , Nolan James , Bagur Rodrigo , de Belder Mark A. , Ludman Peter , Mamas Mamas A. 
Published: February 2018

Background—
Retroperitoneal hemorrhage (RH) is a rare bleeding complication of percutaneous coronary intervention, which can result as a consequence of femoral access or can occur spontaneously. This study aims to evaluate temporal changes in RH, its predictors, and clinical outcomes in a national cohort of patients undergoing percutaneous coronary intervention in the United Kingdom.

Methods and Results—
We analyzed RH events in patients who underwent percutaneous coronary intervention between 2007 and 2014. Multiple logistic regression models were used to identify factors associated with RH and to quantify the association between RH and 30-day mortality and major adverse cardiovascular events. A total of 511 106 participants were included, and 291 in hospital RH events were recorded (0.06%). Overall, rates of RH declined from 0.09% to 0.03% between 2007 and 2014. The strongest independent predictors of RH events were femoral access (odds ratio [OR], 19.66; 95% confidence interval [CI], 11.22–34.43), glycoprotein IIb/IIIa inhibitor (OR, 2.63; 95% CI, 1.99–3.47), and warfarin use (OR, 2.53; 95% CI, 1.07–5.99). RH was associated with a significant increase in 30-day mortality (OR, 3.59; 95% CI, 2.19–5.90) and in-hospital major adverse cardiovascular events (OR, 5.76; 95% CI, 3.71–8.95). A legacy effect was not observed; patients with RH who survived 30 days did not have higher 1-year mortality compared with those without this complication (hazard ratio, 0.97; 95% CI, 0.49–1.91).

Conclusions—
Our results suggest that RH is a rare event that is declining in the United Kingdom, related to transition to transradial access site utilization, but remains a clinically important event associated with increased 30-day mortality but no long-term legacy effect.
An Individual’s Endeavour to Save Sino-Japanese Relations. A Discussion of Wang Tao’s (1828-1897) Travel to Japan based on his Travel Diary
Authors: Tsui Wai 
Published: February 2018

In the spring of 1879, while the relations between Japan and China was deteriorated by a series of disputes in Korea, Taiwan and the Ryukyu Islands, Wang Tao 王韜 (1828-1897), a Chinese scholar, was invited by a group of prominent Japanese intellectuals, including Kurimoto Joun 栗本鋤雲 (1822-1897), Shigeno Yasutsugu 重野安繹 (1827-1910), Nakamura Masanao 中村正直 (1832-1890), and Oka Senjin 岡千仭 (1833-1914), to travel to Japan, exchanging ideas of reform and discussing the crises of Asian countries with increasing Western invasions. Wang Tao was warmly welcomed as an expert of both Chinese Classics and international affairs. Having the objectives of finding out more about the Meiji Japan and promoting friendship and strategic relations between the two countries, Wang and his hosts inevitably started a discussion on modernization, Westernization and future development of the two neighbouring countries. This was a significant intellectual exchange among Chinese and Japanese men of letters in modern history. During his visit, Wang recorded his journey in Fusang youji 扶桑遊記 (A Travel to Japan). Upon returning to China, Wang presented his diary to Kurimoto Joun and the book was published by Yūbin Hōchi, a leading news printing press in Japan.
Although there are research outlining Wang Tao’s travel to Japan, its significance, especially Wang’s vision of the future development of Sino-Japanese relation has not been fully analysed. His travel diary, an important source to reveal Wang’s thought, has only been seen as a record of travel itinerary and personal romance. In fact, his senses of history and knowledge in current affairs have reminded him the threat of an ambitious Japan. He, therefore, endeavoured to rebuild and maintain the link between the two countries from historic, cultural and strategic aspects during his journey. This paper aims to examine how Wang Tao conveyed his messages in inoffensive but effective ways in his travel diary.
Evaluation of adherence to Mediterranean diet in medical students at Kocaeli University, Turkey
Authors: Baydemir Canan , Ozgur Emrah Gokay , Balci Sibel 
Published: February 2018

Introduction This study was conducted to evaluate the eating habits of medical students at Kocaeli University in northwest Turkey in terms of their ability to apply their academic knowledge regarding healthy lifestyles to their own lives using the Mediterranean Diet Quality Index (KIDMED). Methods In this cross-sectional study, a questionnaire including demographic information and the KIDMED index was administered to 354 medical school students (206 first-year and 148 third-year students). The students’ sex, body mass index, KIDMED score, place of residence, smoking habit, media screen time, and regular exercising variables were evaluated. Results The KIDMED score was −2 to 8 (3.8 ± 1.9) among all students, −1 to 8 (3.9 ± 2.0) among first-year students, and −1 to 8 (3.6 ± 1.9) among third-year students. In total, 59.1% of females and 40.9% of males among first-year students showed moderate adherence to the Mediterranean diet, and female students showed better adherence to the Mediterranean diet than males among third-year students. Conclusion Medical students at Kocaeli University in Turkey showed inadequate application of their academic knowledge about healthy living to their own lives.