bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes prevention after gestational diabetes: challenges and opportunities
Authors: Dunne Pauline , Sherry Deirbhile , O’Reilly Sharleen L. 
Published: November 2024

Abstract
Gestational diabetes mellitus (GDM) poses significant health concerns for women and their offspring, with implications that extend beyond pregnancy. While GDM often resolves postpartum, a diagnosis of GDM confers a greater risk of future type 2 diabetes (T2D) and other chronic illnesses. Furthermore, the intergenerational impact of GDM predisposes offspring to increased chronic disease risk. Despite the awareness of the short- and long-term consequences of GDM, translating this knowledge into prevention strategies remains challenging. Challenges arise from a lack of clarity among health professionals regarding roles and responsibilities in chronic disease prevention and women’s lack of awareness of the magnitude of associated health risks. These challenges are compounded by changes in the circumstances of new mothers as they adjust to balance the demands of infant and family care with their own needs. Insights into behaviour change strategies, coupled with advances in technology and digital healthcare delivery options, have presented new opportunities for diabetes prevention among women with a history of GDM. Additionally, there is growing recognition of the benefits of adopting an implementation science approach to intervention delivery, which seeks to enhance the effectiveness and scalability of interventions. Effective prevention of T2D following GDM requires a comprehensive person-centred approach that leverages technology, targeted interventions and implementation science methodologies to address the complex needs of this population. Through a multifaceted approach, it is possible to improve the long-term health outcomes of women with prior GDM.
Evaluation of CD1a immunostaining in the diagnosis of cutaneous leishmaniasis caused by Leishmania donovani in Sri Lanka
Authors: Riyal Hasna , Samaranayake Nilakshi , Amarathunga Priyani , Munidasa Deepani , Karunaweera Nadira 
Published: November 2024

Abstract
Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease, routinely diagnosed by direct light microscopy. The sensitivity of this method is dependent on the number of parasites present in the lesion. Immunoexpression of CD1a surface antigen by Leishmania amastigotes and its application as a diagnostic tool has been recently demonstrated in several species including Leishmania major, Leishmania tropica and Leishmania infantum. Leishmania donovani is the only reported species in Sri Lanka primarily causing CL and its CD1a status remains unexplored. We studied CD1a expression by amastigotes of L. donovani in skin biopsies from 116 patients with suspected CL. The biopsy sections were stained with CD1a clones O10 and MTB1 separately. Slit skin smear (SSS) results were considered the gold standard for diagnosis of CL. 103 cases were confirmed through SSS where 73 of them showed positive parasite staining for CD1a clone MTB1 with 70.9% sensitivity. Positivity was seen mostly in parasites closer to the epidermis. CD1a clone O10 failed to detect any amastigotes. Test sensitivity improved to 74.1% when the analysis was applied only to patients with low/no discernible Leishman-Donovan (LD) bodies in histology. Our findings show that CD1a clone MTB1 successfully stains amastigotes of L. donovani species and can be used as a supplementary diagnostic tool in detecting CL, especially when LD bodies are low in number. This method could be validated to detect other forms of leishmaniasis caused by L. donovani in Indian and sub-Saharan regions.
Ecology and phenology of the bat tick Argas (Carios) dewae (Acari: Argasidae)
Authors: Godinho Lisa , van Lieshout Emile , Griffiths Stephen , Kwak Mackenzie L. 
Published: November 2024

AbstractAlthough 12 soft tick species (Argasidae) are native to Australia, the ecology of most is poorly known. Argas dewae parasitizes several insectivorous bat species and has been recorded on humans. Therefore, understanding its ecology is crucial for wildlife health management and public health preparedness. To address this knowledge gap, A. dewae populations were monitored from 2 bat hosts (Chalinolobus gouldii and Austronomus australis) using bat boxes at 3 sites in Victoria, Australia, for 28 months (July 2005–December 2007). A phenological profile undertaken for A. dewae revealed that tick load on bat hosts increased throughout winter and peaked in the first month of spring, before collapsing and remaining low throughout the drier late spring and summer periods. There was also further investigation of the relationship between 2 response variables (tick infestation risk and tick load) and a range of explanatory variables (body condition index, sex, age class, bioseason, site, bat density per nest box). In C. gouldii, site was the only significant predictor of A. dewae infestation risk, while load was correlated with several variables including age class, sex, bioseason, roost density and body condition index. This paper also reports the first records of A. dewae from 6 bat species in 3 bat families (Miniopteridae: Miniopterus australis; Molossidae: A. australis; Vespertilionidae: Chalinolobus morio, Myotis Macropus, Vespadelus darlingtonia, Vespadelus regulus) and a second record of A. dewae from a human. The first distribution records are presented for A. dewae in South Australia, the Australian Capital Territory and Queensland.
Rhipicephalus simus ticks: new hosts for phleboviruses
Authors: Munjita Samuel Munalula , Mubemba Benjamin , Tembo John , Bates Mathew , Munsaka Sody 
Published: November 2024

AbstractTicks are widespread arthropods that transmit microorganisms of veterinary and medical significance to vertebrates, including humans. Rhipicephalus simus, an ixodid tick frequently infesting and feeding on humans, may play a crucial role in transmitting infectious agents across species. Despite the known association of many Rhipicephalus ticks with phleboviruses, information on R. simus is lacking. During a study in a riverine area in Lusaka Zambia, ten R. simus ticks were incidentally collected from the grass and bushes and subjected to metagenomic next generation sequencing (mNGS) in 2 pools of 5. Analysis detected a diverse microbial profile, including bacteria 82% (32/39), fungi 15.4% (6/39), and viruses 2.6% (1/39). Notably, viral sequence LSK-ZM-102022 exhibited similarity to tick phleboviruses, sharing 74.92% nucleotide identity in the RdRp gene and 72% in the NP gene with tick-borne phlebovirus (TBPV) from Greece and Romania, respectively. Its RNA-dependent RNA polymerase (RdRp) encoding region carried conserved RdRp and endonuclease domains characteristic of phenuiviridae viruses. Phylogenetic analysis positioned LSK-ZM-102022 in a distinct but lone lineage within tick phleboviruses basal to known species like brown dog tick phlebovirus and phlebovirus Antigone. Pair-wise genetic distance analysis revealed similar findings. This study emphasizes the urgency of further research on the ecology, transmission dynamics, and pathogenic potential of LSK-ZM-102022 and related TBPVs, crucial for local and global preparedness against emerging tick-borne diseases.
The lost message of Nils Strindberg: Re-examining an 1897 Andrée balloon expedition mystery
Authors: Lantz Björn , Uusma Bea , Tjernström Michael 
Published: November 2024

Abstract
During the ill-fated 1897 Andrée balloon expedition, Nils Strindberg allegedly dropped a small tin containing a last message for his fiancée onto the island Fuglesongen in northwestern Svalbard, as the expedition crew passed over it in their hydrogen balloon, Örnen. Despite at least one lengthy search on Fuglesongen, the tin has never been found. This paper investigates the hypothesis that the tin was accidentally dropped onto Klovningen, a neighbouring island similar in size and shape, situated approximately 2.4 km east of Fuglesongen. A re-analysis of Strindberg’s original handwritten notes from the balloon flight, along with other primary sources and meteorological analyses, suggests that a targeted search for the tin on Klovningen could be a promising next step in solving this enduring mystery.
Electroretinographic responses to periodic stimuli in primates and the relevance for visual perception and for clinical studies
Authors: Kremers Jan , Huchzermeyer Cord 
Published: November 2024

Abstract
Currently, electroretinograms (ERGs) are mainly recorded while using flashes as stimuli. In this review, we will argue that strong flashes are not ideal for studying visual information processing. ERG responses to periodic stimuli may be more strongly associated with the activity of post-receptoral neurons (belonging to different retino-geniculate pathways) and, therefore, be more relevant for visual perception. We will also argue that the use of periodic stimuli may be an attractive addition to clinically available retinal electrophysiological methods.
The Sequence Argument Against the Procreation Asymmetry
Authors: Adelstein Matthew 
Published: November 2024

AbstractThe procreation asymmetry is a widely held view in ethics, claiming that one should make existing people happy but has no reason to make happy people. Here, I shall present a new objection demonstrating from modest premises that one has a reason to take a sequence of actions that simply creates a happy person; yet this judgment in combination with plausible principles about sequences of actions entails that one has some reason to simply create a happy person. Additionally, I will argue that one's reasons to create a happy person are quite strong.
Variation in the management and treatment of children with giant coronary artery aneurysm following Kawasaki disease
Authors: Chen Mia , Dionne Audrey , Choueiter Nadine F. , Harahsheh Ashraf S. , Tierney Seda , Navarro Castellanos Iñaki , Dahdah Nagib 
Published: November 2024

AbstractObjectives:Giant coronary artery aneurysms are rare but potentially fatal complications of Kawasaki disease. The lack of evidence-based recommendations on their management and treatment cause guidelines and practices to differ. We aimed to assess these variations.Methods:An anonymous online survey regarding surveillance, imaging, pharmacological management, and interventional practices was distributed among 134 physicians attending to Kawasaki disease patients worldwide. A p-value of <0.05 was deemed significant.Results:The majority (60%) of respondents were general paediatric cardiologists, and 29% interventional specialists. The average years in practice was 15 ± 9.6. Physicians from Asia had the most experience with giant coronary artery aneurysms. American practitioners preferred combining anticoagulants with aspirin. Beta-blockers and statins were more likely used in teenagers versus younger children. Cardiac catheterisation was most (52%) chosen for coronary surveillance in patients with echocardiogram anomalies, followed by Coronary CT-angiography. The indications for coronary intervention were split among respondents, regardless of geographic region or experience. The preferred treatment of coronary stenosis was percutaneous intervention (69%) versus bypass surgery. For thrombosis, thrombolytics (50%) were preferred over percutaneous (39%) and surgical (11%) interventions. Most (92%) preferred intervening in young children in a paediatric facility but were split between a paediatric and adult facility for older children. Most chose combined management by adult and paediatric specialists for either age-scenarios (70, 82%).Conclusion:As identified by our study, the lack of large studies and evidence-based recommendations cause uncertainty and ambivalence towards certain treatments. International collaborative efforts are needed to provide more robust evidence in the management of these patients.
Isolated very low QRS voltage in at least one frontal lead is associated with vasovagal syncope in children
Authors: Gao Yumeng , Xu Yanyan , Sun Yan , Zhang Qingyou 
Published: November 2024

AbstractObjective:To assess whether isolated very low QRS voltage of ≤0.3 mV in the frontal leads might be a marker for diagnosing paediatric vasovagal syncope and the risk of recurrence.Methods:We included 118 children with vasovagal syncope, comprising 70 males and 48 females in our retrospective analysis. All patients underwent head-up tilt test and supine 12-lead electrocardiography. Furthermore, the QRS voltage was measured from each one of the 12 leads on basal electrocardiography. Patients were followed up for 6–24 months (average, 16 months).Results:Eighty-six patients (73%) patients displayed isolated very low QRS voltage in frontal leads. Furthermore, the patients were classified into two groups based on the presence or absence of isolated very low QRS voltage. Enhanced syncopic spells over the past 6 months, and the positive rates of head-up tilt test were observed in patients having isolated very low QRS voltage in the frontal leads than those without isolated very low QRS voltage (p < 0.05). The single factor and time-to-event analyses also showed an increased syncope recurrence rate in patients with isolated very low QRS voltage in frontal leads when compared with those without isolated very low QRS voltage (p < 0.01).Conclusions:Isolated very low QRS voltage in frontal leads is correlated with the positive response of the head-up tilt test in children who experience syncope and its recurrence post-treatment. Hence, isolated very low QRS voltage in frontal leads might become a novel diagnostic indicator and a risk factor for syncope recurrence in children with vasovagal syncope.
Working memory multicomponent model outcomes in individuals with traumatic brain injury: Critical review and meta-analysis
Authors: Lambez Bar , Vakil Eli , Azouvi Philippe , Vallat-Azouvi Claire 
Published: November 2024

AbstractObjective:Traumatic Brain Injury (TBI) often leads to cognitive impairments, particularly regarding working memory (WM). This meta-analysis aims to examine the impact of TBI on WM, taking into account moderating factors which has received little attention in previous research, such as severity of injury, the different domains of Baddeley’s multi-component model, and the interaction between these two factors, as well as the interaction with other domains of executive functions.Method:Following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, a systematic review and meta-analysis searched Google Scholar, PubMed, and PsycNET for studies with objective WM measures. Multiple meta-analyses were performed to compare the effects of TBI severity on different WM components. Twenty-four English, peer-reviewed articles, mostly cross-sectional were included.Results:TBI significantly impairs general WM and all Baddeley’s model components, most notably the Central Executive (d’ = 0.74). Severity categories, mild-moderate and moderate-severe, were identified. Impairment was found across severities, with “moderate-severe” demonstrating the largest effect size (d’ = 0.81). Individuals with moderate-severe TBI showed greater impairments in the Central Executive and Episodic Buffer compared to those with mild-moderate injury, whereas no such differences were found for the Phonological Loop and Visuospatial Sketchpad.Conclusions:These findings enhance our understanding of WM deficits in varying severities of TBI, highlighting the importance of assessing and treating WM in clinical practice and intervention planning.
AN EXAMPLE OF THE JANTZEN FILTRATION OF A D-MODULE
Authors: BOHUN SIMON , ROMANOV ANNA 
Published: November 2024

Abstract
We compute the Jantzen filtration of a

$\mathcal {D}$

-module on the flag variety of

$\operatorname {\mathrm {SL}}_2(\mathbb {C})$

. At each step in the computation, we illustrate the

$\mathfrak {sl}_2(\mathbb {C})$

-module structure on global sections to give an algebraic picture of this geometric computation. We conclude by showing that the Jantzen filtration on the

$\mathcal {D}$

-module agrees with the algebraic Jantzen filtration on its global sections, demonstrating a famous theorem of Beilinson and Bernstein.
THE PRODUCT OF A GENERALIZED QUATERNION GROUP AND A CYCLIC GROUP
Authors: DU SHAOFEI , LUO WENJUAN , YU HAO 
Published: November 2024

AbstractLet
$X=GC$
be a group, where C is a cyclic group and G is either a generalized quaternion group or a dihedral group such that
$C\cap G=1$
. In this paper, X is characterized and, moreover, a complete classification for
$X$
is given, provided that G is a generalized quaternion group and C is core-free.
Wer Viewership and Queer Imag(in)ing: Thai Soap Opera Shadow of Love and Boys Love Media
Authors: Chao Shi-Yan , Chunsaengchan Palita , Chaochuti Thosaeng 
Published: November 2024

Abstract
This article brings film/media theory into Southeast Asian research through a revisionist queer approach. It contains two goals: addressing some recent developments about queer imag(in)ing in Thai media whilst reappraising the fundamental question of spectatorship via screen theory. Taking into account the more general issue of media specificity and the particular textual device of identity/gender-switch in several recent Thai television serials, we propose the notion of wer viewership: a mode of viewing practice that features viewer-text interaction through the perceptual-cognitive processes, and is characterised by wer/excessive aesthetics, multiple meanings, and diverse pleasures. Resonant with camp reading, wer viewership underlines how the viewer actively makes sense of the ambiguities about gender, particularly those along the extra-/diegetic interface. We use Thai soap opera Shadow of Love to illuminate the wer/excessive aesthetics rendered through its identity/gender play bordering on the extra-/diegetic divide, and the enhanced pleasures and meanings thus available to its extradiegetic active viewers. We stress, though, the expanded queer imag(in)ing in Shadow is not of total free interpretation, but is animated in relation to both the evolving discourses about gender/sexuality in Thailand, and the popularising homoerotic Boys Love (BL) media across Asia in recent years.
Dynamic Coupling Between Intensified Physical Erosion and Asian Dust Activity Under Late Cenozoic Global Cooling
Authors: Wang Shuwen , Zan Jinbo , Heller Friedrich , Fang Xiaomin , Liu Xiaoming 
Published: November 2024

AbstractDistinguishing the independent contributions of tectonic denudation and climate‐driven erosion on the production and supply of clastic materials of Chinese eolian deposits is important in understanding the dynamic links between global climate changes, tectonics, and Asian dust emission. Here, multi‐proxy rock magnetic records of detrital fractions of Chinese eolian deposits since ∼6 Ma, combined with further comparison with dust accumulation rates and geochemical data, suggest that limited production and supply of clastic materials of Chinese eolian deposits were observed between 5.6 and 4.4 Ma in a warmer climate, and thereafter an increasing trend is evident during a cooler world. We propose that intense physical erosion under cooler conditions caused increasing production of fresh detrital components, exerting dominant influences on the sediment supply to Asian eolian deposits. This study provides direct evidence of dynamic coupling between intensified physical erosion and Asian dust activity under late Cenozoic global cooling.
Quantifying the Mesoscale Contribution to FACs During a Magnetospheric Substorm
Authors: Gasparini S. , Kepko L. , Laundal K. M. 
Published: November 2024

AbstractMesoscales, which couple small to large scales, and vice‐versa, are critical to the magnetosphere‐ionosphere coupling. Optical and radar measurements indicate that dynamical mesoscale features are present in the ionosphere, however quantifying their contribution to the overall dynamics remains a challenge. We use a new ionospheric data assimilation technique, Lompe (Local mapping of the polar ionospheric electrodynamics), to specify ionospheric electrodynamics using a wide variety of input data and a priori assumptions about the physical nature of the ionospheric electric field. We isolate the terms of the ionospheric Ohm's law and find that mesoscale structures in the FACs are driven by Hall gradients, while the larger scale patterns are associated with the divergence of the electric field. We calculate the relative contribution of mesoscales to the overall FAC patterns during a magnetospheric substorm, and find that in the nightside, mesoscale FACs contribute up to 60% of the total.
Tectonic Implications of Early Permian Arc Rocks and Their Cretaceous to Early Cenozoic Reworking in Southern Lhasa Terrane, Tibet
Authors: Ding Huixia , Kohn Matthew J. , Zhang Zeming , Niu Zhixiang 
Published: November 2024

AbstractThe Lhasa terrane in southern Tibet occupies a central position in Asian tectonics, yet its pre‐Mesozoic petrologic and tectonic evolution is poorly constrained, especially the Southern Lhasa subterrane (SLS). Here, new zircon U–Pb ages, zircon trace element and Hf isotopic compositions, and whole‐rock geochemical data for mafic meta‐igneous rocks from the SLS distinguish three tectono‐thermal events at ∼290 Ma, ∼126 Ma and ∼49 Ma. Whole‐rocks and zircons with ages of the two older events have arc magma geochemistry, but Hf isotopes are distinct from Mesozoic Gangdese arc magmas. Zircon cores and, arguably, whole rocks instead derive from ∼290 Ma magma formed during southward subduction of Paleo‐Tethys beneath the SLS. These rocks later underwent Early Cretaceous (∼126 Ma) remelting and early Cenozoic (∼49 Ma) metamorphism with P–T conditions of ~800°C and 15.3 kbar, and record a retrograde P–T path characterized by exhumation with cooling, consistent with a collisional origin. These data suggest Permian igneous rocks underwent reworking during both the Early Cretaceous and the early Cenozoic, reaching crustal thicknesses of at least ~50 km during the early Eocene. Combined with regional data, Paleo‐Tethys evidently experienced early Permian double‐sided subduction within the Lhasa terrane, with back arc basins forming between the SLS and the Indian margin to the south. These back arc basins ultimately widened to form the Neo‐Tethys Ocean, which then subducted during the Mesozoic, leading to Cretaceous arc magmatism and overprinting, followed by early Cenozoic metamorphism and final reworking during collision with India.
Influencing immunity: role of extracellular vesicles in tumor immune checkpoint dynamics
Authors: Ye Ziyang , Li Genpeng , Lei Jianyong 
Published: November 2024

Abstract
Immune checkpoint proteins (ICPs) serve as critical regulators of the immune system, ensuring protection against damage due to overly activated immune responses. However, within the tumor environment, excessive ICP activation weakens antitumor immunity. Despite the development of numerous immune checkpoint blockade (ICB) drugs in recent years, their broad application has been inhibited by uncertainties about their clinical efficacy. A thorough understanding of ICP regulation in the tumor microenvironment is essential for advancing the development of more effective and safer ICB therapies. Extracellular vesicles (EVs), which are pivotal mediators of cell–cell communication, have been extensively studied and found to play key roles in the functionality of ICPs. Nonetheless, a comprehensive review summarizing the current knowledge about the crosstalk between EVs and ICPs in the tumor environment is lacking. In this review, we summarize the interactions between EVs and several widely studied ICPs as well as their potential clinical implications, providing a theoretical basis for further investigation of EV-related ICB therapeutic approaches.