bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico mouse study identifies tumor growth kinetics as biomarkers for the outcome of anti-angiogenic treatment
Authors: Wu Qianhui , Arnheim Alyssa D. , Finley Stacey D. 
Published: April 2018

AbstractAngiogenesis is a crucial step in tumor progression, as this process allows tumors to recruit new blood vessels and obtain oxygen and nutrients to sustain growth. Therefore, inhibiting angiogenesis remains a viable strategy for cancer therapy. However, anti-angiogenic therapy has not proved to be effective in reducing tumor growth across a wide range of tumors, and no reliable predictive biomarkers have been found to determine the efficacy of anti-angiogenic treatment. Using our previously established computational model of tumor-bearing mice, we sought to determine whether tumor growth kinetic parameters could be used to predict the outcome of anti-angiogenic treatment. A model trained with datasets from six in vivo mice studies was used to generate a randomized in silico tumor-bearing mouse population. We analyzed tumor growth in untreated mice (control) and mice treated with an anti-angiogenic agent and determined the Kaplan-Meier survival estimates based on simulated tumor volume data. We found that the ratio between two kinetic parameters, k0 and k1, which characterize the tumor’s exponential and linear growth rates, as well as k1 alone, can be used as prognostic biomarkers of population survival outcome. Our work demonstrates a robust, quantitative approach for identifying tumor growth kinetic parameters as prognostic biomarkers and serves as a template that can be used to identify other biomarkers for anti-angiogenic treatment.
Transforming and empowering higher education through Open and Distance Learning in India
Authors: Bordoloi Ritimoni 
Published: April 2018

Purpose
Higher education should bring up the multifaceted development of human resources by promoting the knowledge-enabled population that will bring socio-economic mobility, peace and progress in society. Thus, the educational providers must undertake the duty to impart need-based higher education that makes people educated with a progressive, rational, analytical, and skilful mind. Hence, there is an urgent need to address some basic challenges of higher education such as required educational avenues or institutional set up against the demand of the population, achievements in global learning, providing room for equal access to learning, research on cost benefit analysis, educational innovations and partnership, use of educational technology, quality assurance mechanism, need for adequate funds for the expansion of higher education, and so on. Once these challenges are addressed, transformation of the society can be a reality, and Open and Distance Learning (ODL) system is one of the most viable ways for transforming a country like India. The paper aims to discuss these issues.

Design/methodology/approach
For this study, descriptive research methodology has been used, and analysis has been done based on the data extracted from the secondary sources of information such as Census of India 2011; India Human Development Report 2011; Human Development Report 2014, 2015; Economic Survey 2015-2016; NFHS-I, II, III and IV; Report of 11th Five Years Plan; 12th FYP; Annual Report 2015-16, MHRD; Annual Report of NSS, 2016, etc.

Findings
ODL can be raised as an alternative way for making education accessible and for providing scope for skill-based education at a minimum cost. In fact, ODL, in particular, can play a significant role in transforming and empowering the vibrant adult population of a country like India into productive human resources by providing need-based training and equipping them with need-based skills, which are necessary for maintaining a decent standard of living.

Social implications
Through this paper, it could be realised how ODL provides the opportunity of education to a large section of people in the society irrespective of sex and age, and how ODL has made the people capable with basic and essential kills which are necessary for maintaining a decent standard of living.

Originality/value
ODL could be a most viable option to mobilise the higher education system in India. This paper helps to contextualise ODL in empowering and transforming society, and the finding, and discussions have been made with reference to the various initiatives taken in the field of skill-based education through ODL in a country like India.
Impact of social media strategies on stock price: the case of Twitter
Authors: Chahine Salim , Malhotra Naresh K. 
Published: April 2018

Purpose
Social media have recently become an important strategic marketing tool to increase firm value. Based on an integrated theoretical framework, this study aims to examine the market reaction at the time of the creation of a Twitter platform for 312 firms from the Fortune 500 firms.

Design/methodology/approach
To test the hypotheses related to the effect of social media platforms on firm value, the event history analysis (EHA) was used, also known as event study, usually designed to examine the impact of a historical phenomenon for the US Fortune 500 firms that developed a Twitter platform.

Findings
A significant market reaction was found around the starting date of Twitter activities for the subsample of firms that are not contaminated by any other corporate announcements, but not for the overall sample. The market reaction is higher for firms with two-way interaction strategies rather than one-way messaging in both the uncontaminated subsample and the overall sample. It is higher in smaller firms, firms with losses and those with a family and/or a dominant shareholder. Further, firms in the contaminated subsample are likely to follow a two-way strategy after a positive revision of their earnings per share. We have run several robustness checks, including cross-validation on a holdout sample, and these findings remain consistent.

Research limitations/implications
The integrated theoretical framework is another significant contribution. To our knowledge, this is the first study across disciplines that integrates the social exchange theory (SET), social representation theory (SRT), social network analysis (SNA), social identity theory (SIT), signaling theory (ST) and the impression management theory (IMT) into one framework that is built around information as a resource and social interaction.

Practical implications
The results suggest that Twitter can be used to add value if firms interact and reciprocate with the various stakeholders.

Social implications
Firms using social media must interact and reciprocate with the various stakeholders.

Originality/value
This research is different than the published research on this topic in that it examines the impact on stock prices of the introduction of a specific social media platform, i.e. Twitter. The present results of the paper add to the prior research on database marketing and show that marketing “with” the customer is adding more value than marketing “to” the customer. The use of the net extends the scope of database marketing into a certain form of interaction marketing with “face-to-face” interaction within the relationships between the firm and its customers. Finally, the conditions under which social media platforms are used in an interactive manner are shown, and depicts that firms are more likely to use a two-way interactive strategy following a one-year period of positive momentum.
Sustainable forest management in Poland
Authors: Bartniczak Bartosz , Raszkowski Andrzej 
Published: April 2018

Purpose
The purpose of this paper is to analyse sustainable forest management in Poland in the years 2009-2015. The concept of sustainable development itself has also been analysed as the starting point for sustainable forest management development. Based on the conducted analysis of statistical data, it was attempted to answer the question about the condition of sustainable forest management in Poland.

Design/methodology/approach
Two basic research methods were used in the presented paper. The first of them was the analysis of existing data. The conducted analysis covered the subject literature, reports and analyses referring to forest management. The second applied research method was the statistical analysis which covered structure analysis and dynamics analysis.

Findings
It can be adopted, within the framework of general conclusions, that the condition of sustainable forest management in Poland is moderately satisfactory, with the reservation of the need to maintain and intensify all processes and projects aimed at the implementation of the broadly approached concept of sustainable development.

Originality/value
The core of the study is focused on the statistical analysis of selected forest management aspects in Poland in the context of the assessment of sustainable forest management condition, with particular emphasis on forest cover, defoliation, forest area, restoration and afforestation, tree planting, wood harvesting, average wood sales price, excluding land from forest production for non-forest purposes. The importance of environmental education was also highlighted.
Power-aware workload allocation for green data centers
Authors: Chaddad Louma Ahmad , Chehab Ali , Elhajj Imad , Kayssi Ayman 
Published: April 2018

Purpose
The purpose of this paper is to present an approach to reduce energy consumption in data centers. Subsequently, it reduces electricity bills and carbon dioxide footprints resulting from their use.

Design/methodology/approach
The authors present a mathematical model of the energy dissipation optimization problem. The authors formulate analytically the server selection problem and the supply air temperature as a non-linear programming, and propose an algorithm to solve it dynamically.

Findings
A simulation study on SimWare, using real workload traces, shows considerable savings for different data center sizes and utilization rates as compared to three other classic algorithms. The results prove that the proposed algorithm is efficient in handling the energy-performance trade-off, and that the proposed algorithm provides significant energy savings and maintains a relatively homogenous and stable thermal state at the different rack units in the data center.

Originality/value
The proposed algorithm ensures energy provisioning, performance optimization over existing state-of-the-art heuristics, and on-demand workload allocation.
European Agricultural Science Funding: Examining Trends and Prospects
Authors: Chartier Olivier , Doghmi Myriam , Fligny Cècile 
Published: April 2018

SummaryProper evaluation of the impact of agricultural research requires data on how much has been spent to achieve its desired effects on productivity, efficiency and environmental quality. However, official statistics on aggregate volumes of research expenditure, at both European and national levels, are intermittently available and most data collected for private research are not fully compatible with data for public research. This study in 20 European countries in 2014 defines the different concepts at international level, and assesses coverage across countries, using secondary data and key informant interviews. Coverage is unequal by country and type of measure, the lowest coverage being for agriculture as a socioeconomic objective. We depict recent trends in public agricultural research, which differ by country. We then formulate three policy options and recommendations for their implementation to improve the monitoring of agricultural research investment in Europe: 1) make compulsory in the EU statistical system the collection of statistics on agricultural research expenditure using the same metrics for all sectors of performance; 2) develop a specific survey in the Commission to obtain data directly from research organisations; 3) prepare annual reviews of agricultural research expenditures at Member State level, including both quantitative and qualitative information on agricultural research activities.
Editorial: optimal dose of carvedilol in portal hypertension…nearly there
Authors: Tripathi D. , Stanley A. J. 
Published: April 2018

Linked ContentThis articel is linked to Schwarzer et al and Reiberger and Ferlitsch papers. To view these articles visit https://doi.org/10.1111/apt.14576 and https://doi.org/10.1111/apt.14614.
Editorial: the prevalence of Helicobacter pylori infection worldwide—knowns and unknowns
Authors: Tsipotis E. , Leontiadis G. I. 
Published: April 2018

Linked ContentThis article is linked to Zamani et al papers. To view these articles visit https://doi.org/10.1111/apt.14561 and https://doi.org/10.1111/apt.14618.
Patientenzufriedenheit von 1827 Patienten nach verschiedenen Rekonstruktionsmethoden im Gesichtsbereich in Abhängigkeit von Alter, Defektgröße und Lokalisation
Authors: Schnabl Saskia Maria , Breuninger Helmut , Iordanou Eleni , Scheu Alexander , Kofler Lukas , Häfner Hans‐Martin , Eberle Franziska Carola 
Published: April 2018

ZusammenfassungHintergrundNach Tumoroperationen erfolgt ein Defektverschluss mit den für den individuellen Fall optimalen chirurgischen Methoden. Besonders im Kopf‐Hals‐­Bereich ist das Ergebnis sehr wichtig. Ziel der retrospektiven Studie war es, Rekonstruktionsmethoden von Defekten entsprechend Alter, Lokalisation und Größe nach funktionellen und ästhetischen Gesichtspunkten zu vergleichen.Patienten und MethodikDie betroffenen Patienten wurden mittels Fragebögen angeschrieben. 1827 Patienten (Alter von 18 bis 92 Jahren, Median: 56 Jahre) beurteilten postoperative Probleme, ästhetisches sowie funktionelles Ergebnis und das Gesamtresultat. Aus der Patientenakte wurden Größe und Lokalisation des Defektes sowie die Art des Verschlusses dokumentiert.ErgebnisseDie Dehnungslappenplastik erhielt bezüglich des Gesamtresultats mit einer sehr guten oder guten Bewertung (86 %) das beste Ergebnis. Lappenplastiken und Hauttransplantate wurden schlechter beurteilt. Postoperative Beschwerden traten signifikant häufiger nach lokalen Lappenplastiken auf. Die Sichtbarkeit der Narbe wurde von älteren Patienten bei allen Defektgrößen (< 150 mm2, 150–300 mm2, > 300 mm2) geringer beurteilt als von jüngeren. Narben in der zentralen Gesichtspartie wurden als sichtbarer wahrgenommen. Geschlecht und Rauchen hatten keinen Einfluss.SchlussfolgerungenNarben in zentralen Gesichtsregionen werden stärker wahrgenommen. Ältere Patienten beurteilten die Narbenbildung insgesamt als unauffälliger. Dehnungslappenplastiken, auch unter Wundrandspannung, führen zu sehr guten Ergebnissen und einer hohen Patientenzufriedenheit.
S1 Guidelines – Dermatoses associated with dermal lymphostasis
Authors: Dissemond Joachim , Jockenhöfer Finja , Miller Anya , Kurzhals Günter , Noori Shahrouz , Reich‐Schupke Stefanie , Schlaeger Martin , Schubert Erich , Stücker Markus , Weberschock Tobias , Jungkunz Hans Wilfried 
Published: April 2018

SummaryThe objective of the present S1 guidelines is to present current knowledge about dermatologically relevant diseases associated with localized dermal lymphostasis, thus facilitating their early detection, diagnostic workup, and targeted treatment. Whenever possible, treatment should be based on stage‐appropriate and clearly defined algorithms. The numerous issues regarding differential diagnosis and treatment clinicians are confronted with in everyday clinical practice seem to warrant the publication of up‐to‐date guidelines.These guidelines focus on patients of all age groups and genders exhibiting skin lesions caused by dermal lymphostasis. Specific recommendations are provided with respect to the diagnosis and differential diagnosis of the various clinical manifestations. In this context, comorbid skin diseases such as atopic dermatitis, psoriasis, hidradenitis suppurativa, urticaria, and contact dermatitis will be highlighted, including their treatment and associated specific risks. Several other relevant current guidelines are referenced as regards the distinction from and treatment of common cofactors and comorbid conditions.
S1‐Leitlinie – Dermatosen bei dermaler Lymphostase
Authors: Dissemond Joachim , Jockenhöfer Finja , Miller Anya , Kurzhals Günter , Noori Shahrouz , Reich‐Schupke Stefanie , Schlaeger Martin , Schubert Erich , Stücker Markus , Weberschock Tobias , Jungkunz Hans Wilfried 
Published: April 2018

ZusammenfassungDas Ziel dieser S1‐Leitlinie ist es, aktuelles Wissen über dermatologisch relevante Krankheitsbilder bei lokal begrenzter dermaler Lymphostase an allen Lokalisationen des Hautorgans zu vermitteln, um diese frühzeitig zu erkennen, diagnostisch zu sichern und gezielt zu behandeln. Wann immer möglich, sollte diese Therapie anhand klar definierter Algorithmen stadiengerecht erfolgen. Die im klinischen Alltag häufig auftauchenden differenzialdiagnostischen und therapeutischen Fragen lassen eine aktuelle Leitlinie notwendig erscheinen.Diese Leitlinie fokussiert auf Patienten jeglichen Alters und Geschlechts mit Hautveränderungen, die im kausalen Zusammenhang mit dermaler Lymphostase stehen. In konkreten Handlungsempfehlungen werden die Diagnostik und Differenzialdiagnostik der verschiedenen Manifestationsformen bei gleichzeitig auftretender dermatologischer Komorbidität wie beispielsweise atopische Dermatitis, Psoriasis vulgaris, Acne inversa, Urtikaria, Kontaktekzeme sowie ihre Therapien unter Berücksichtigung besonderer Risiken veranschaulicht. Für die Abgrenzung und Behandlung häufiger therapierelevanter Kofaktoren und Komorbidität wird auf mehrere andere hierfür relevante aktuelle Leitlinien verwiesen.
Incremental value of left atrial active function measured by speckle tracking echocardiography in patients with hypertrophic cardiomyopathy
Authors: Fujimoto Kaori , Inoue Katsuji , Saito Makoto , Higashi Haruhiko , Kono Tamami , Uetani Teruyoshi , Aono Jun , Nagai Takayuki , Nishimura Kazuhisa , Suzuki Jun , Okura Takafumi , Ikeda Shuntaro , Nakatani Satoshi , Higaki Jitsuo 
Published: April 2018

PurposeHypertrophic cardiomyopathy (HCM) impairs left ventricular (LV) diastolic function leading to left atrial (LA) dilatation. Because Doppler echocardiography cannot accurately assess LV diastolic function in hearts with heterogeneous hypertrophy, assessment of LA function might be useful for risk stratification of patients with HCM. This study aimed to elucidate the impact of LA function on outcome in patients with patients.MethodsSeventy‐six patients with HCM who underwent echocardiographic and cardiac magnetic resonance imaging were retrospectively enrolled. Twenty‐six control subjects were also included. Using speckle tracking echocardiography, LA function was divided into active and passive strain indices based on the timing of the second positive peak of LA strain rate that occurred during LV systole.ResultsLeft atrial strain indices of active and passive function were significantly impaired concomitantly with increased LA volume index in HCM patients compared with controls. During follow‐up (2.6 ± 1.7 years), 14 patients with HCM developed cardiac events (heart failure hospitalization or atrial fibrillation). The association of LA active strain with cardiac events was independent of and incremental to clinical and echocardiographic parameters (age, gender, E/e′, LV global longitudinal strain, and LA volume index) in sequential models. Cardiac events were more frequent in HCM patients with LA active strain <20.3% than with active strain ≥20.3% (P = .01).ConclusionLoss of LA active function was associated with increased cardiac events in patients with HCM.
Abnormal ventricular repolarization in long QT syndrome carriers is related to short left ventricular filling time and attenuated stroke volume response during exercise
Authors: Charisopoulou Dafni , Koulaouzidis George , Rydberg Annika , Henein Michael Y. 
Published: April 2018

BackgroundLong QT syndrome (LQTS) carriers are characterized by abnormal ventricular repolarization, prolonged systole, and mechanical dispersion. Prolonged left ventricular (LV) systole has been shown to result in disproportionate shortening of LV filling in other conditions. The aim of this study was to assess LV filling, diastolic function, and stroke volume (SV) response to dynamic exercise, in a group of LQTS carriers.MethodsForty‐seven LQTS carriers (45 ± 15 years, 20 symptomatic) and 35 healthy individuals underwent bicycle stress echocardiogram. Electrocardiographic and echocardiographic measurements were obtained at rest, peak exercise, and 4 minutes into recovery.ResultsLong QT syndrome carriers and controls did not differ in age, gender, heart rate, QRS duration, or LV ejection fraction. At rest, LQTS carriers had longer QTc and shorter filling time (FT). At peak exercise, QTc increased and remained longer than controls at recovery. A negative correlation was found between QTc and FT (r = −.398, P = .001) with greater fall in FT in LQTS carriers than in controls at peak exercise (−23% ± 10 vs +2% ± 3, P < .0001). FT correlated with SV (r = +.27, P = .001), which increased more in controls than in LQTS carriers (+32% ± 4 vs +2% ± 1, P < .05). These differences were more pronounced in symptomatic LQTS carriers who had shorter FT and smaller SV at peak exercise and during recovery compared to asymptomatics (P < .05).ConclusionsLong QT syndrome carriers have longer QTc, but also shorter FT. These disturbances worsen at peak exercise (particularly in symptomatics) compromising LV filling and SV, hence a potential pathomechanism for adverse events.
Call recognition and female choice in a treefrog with a multicomponent call
Authors: Oliva Mark V. , Kaiser Kristine , Robertson Jeanne M. , Gray David A. 
Published: April 2018

AbstractAcoustic mating signals are typically species‐specific, and often additionally are subject to directional female preferences. Male executioner treefrogs, Dendropsophus carnifex, produce a multicomponent advertisement call composed of an introductory screech note followed by two or more click notes. Here, we tested (i) call recognition by comparing female directed phonotaxis towards individual and combined call components: screech vs. clicks vs. screech + clicks, (ii) female preferences for greater numbers of click notes and (iii) female preferences for faster call rates. The results demonstrated that screeches and clicks, presented either separately or together as a complete call, evoke similar female responses, suggesting that either note was sufficient to elicit a mate‐recognition response. Additionally, females preferred calls with greater numbers of click notes and with faster call rates. We interpret these results within the context of female mate selection in natural choruses.