bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Phase II Study of Acimtamig (AFM13) in Patients with CD30-Positive, Relapsed, or Refractory Peripheral T-cell Lymphomas
Authors: Kim Won Seog , Shortt Jake , Zinzani Pier Luigi , Mikhailova Natalia , Radeski Dejan , Ribrag Vincent , Domingo Domenech Eva , Sawas Ahmed , Alexis Karenza , Emig Michael , Elbadri Riham , Hajela Pallavi , Ravenstijn Paulien , Pinto Sheena , Garcia Linta , Overesch Andre , Pietzko Kerstin , Horwitz Steven 
Published: November 2024

Abstract

Purpose:
Patients with relapsed or refractory (R/R) peripheral T-cell lymphoma (PTCL) generally have poor prognoses and limited treatment options. This study evaluated the efficacy of a novel CD30/CD16A bispecific innate cell engager, acimtamig (AFM13), in patients with R/R PTCL.

Patients and Methods:
Patients included those with CD30 expression in ≥1% of tumor cells and who were R/R following ≥1 prior line of systemic therapy. Acimtamig (200 mg) was administered once weekly in 8-week cycles. The primary endpoint was the overall response rate by fluorodeoxyglucose-PET per independent review committee; secondary and exploratory endpoints included duration of response, safety, progression-free survival, and overall survival.

Results:
The overall response rate in 108 patients was 32.4% [95% confidence interval (CI), 23.7, 42.1] with a complete response rate of 10.2% (95% CI, 5.2, 17.5); the median duration of response was 2.3 months (95% CI, 1.9, 6.5). Patients with R/R angioimmunoblastic T-cell lymphoma exhibited the greatest number of responses [53.3% (95% CI, 34.3, 71.7)]. Responses were independent of CD30 expression level, prior brentuximab vedotin treatment, or steroid premedication. Acimtamig exhibited a tolerable safety profile; the most common treatment-related adverse events were infusion-related reactions in 27 patients (25.0%) and neutropenia in 11 patients (10.2%). No cases of cytokine release syndrome or acimtamig-related deaths were reported. Despite exhibiting promising clinical activity and tolerable safety in a heavily pretreated PTCL population, the study did not meet the criteria for the primary endpoint.

Conclusions:
The promising clinical efficacy observed warrants further investigation, and development of acimtamig for patients with R/R CD30+ lymphomas continues in combination with allogeneic NK cells.
Phase Ib Clinical and Pharmacodynamic Study of the TIE2 Kinase Inhibitor Rebastinib with Paclitaxel or Eribulin in HER2-Negative Metastatic Breast Cancer
Authors: Anampa Jesus D. , Flynn Daniel L. , Leary Cynthia , Oh Sun , Xue Xiaonan , Oktay Maja H. , Condeelis John S. , Sparano Joseph A. 
Published: November 2024

Abstract

Purpose:
Breast cancer cells disseminate to distant sites via tumor microenvironment of metastasis (TMEM) doorways. The TIE2 inhibitor rebastinib blocks TMEM doorway function in the PyMT mouse model of breast cancer. We aimed to assess the safety and pharmacodynamics of rebastinib plus paclitaxel or eribulin in patients with HER2-negative metastatic breast cancer (MBC).

Patients and Methods:
This phase Ib trial enrolled 27 patients with MBC who received 50 mg or 100 mg of rebastinib orally twice daily in combination with weekly paclitaxel 80 mg/m2 (if ≤2 prior non-taxane regimens) or eribulin 1.4 mg/m2 on days 1 and 8 (if ≥1 prior regimen). Safety, tolerability, and pharmacodynamic parameters indicating TIE2 kinase inhibition and TMEM doorway function were evaluated.

Results:
No dose-limiting toxicities in cycle 1 or 2 were observed among the first 12 patients at either rebastinib dose level. The most common treatment-emergent adverse events were anemia (85%), fatigue (78%), anorexia (67%), leukopenia (67%), increased alanine aminotransferase (59%), hyperglycemia (56%), nausea (52%), and neutropenia (52%). Adverse events attributed to rebastinib include muscular weakness and myalgias. Intraocular pressure increased at the 100-mg rebastinib dose level, whereas angiopoietin-2 levels increased at both dose levels, providing pharmacodynamic evidence for TIE2 blockade. Circulating tumor cells decreased significantly with the combined treatment. Objective response occurred in 5/23 (22%) evaluable patients.

Conclusions:
In patients with MBC, the recommended phase II dose of rebastinib associated with pharmacodynamic evidence of TIE2 inhibition is either 50 or 100 mg orally twice daily in combination with paclitaxel or eribulin.
Targeting of Tumoral NAC1 Mitigates Myeloid-Derived Suppressor Cell–Mediated Immunosuppression and Potentiates Anti–PD-1 Therapy in Ovarian Cancer
Authors: Dong Shunli , Ye Cong , Li Bin , Lv Fanglin , Zhang Lu , Yang Shumin , Wang Fang , Zhu Mingxian , Zhou Mingxuan , Guo Fanfan , Li Zhenyun , Peng Lei , Ji Cheng , Lu Xialiang , Cheng Yan , Ren Xingcong , Chen Youguo , Zhou Jinhua , Yang Jinming , Zhang Yi 
Published: November 2024

Abstract
Epithelial ovarian cancer is the most common type of ovarian cancer with a low rate of response to immunotherapy such as immune checkpoint blockade therapy. In this study, we report that nucleus accumbens–associated protein 1 (NAC1), a putative driver of epithelial ovarian cancer, has a critical role in immune evasion. We showed in murine ovarian cancer models that depleting or inhibiting tumoral NAC1 reduced the recruitment and immunosuppressive function of myeloid-derived suppressor cells (MDSC) in the tumor microenvironment, led to significant increases of cytotoxic tumor-infiltrating CD8+ T cells, and promoted antitumor immunity and suppressed tumor progression. We further showed that tumoral NAC1 directly enhanced the transcription of CXCL16 by binding to CXCR6, thereby promoting MDSC recruitment to the tumor. Moreover, lipid C20:1T produced by NAC1-expressing tumor cells fueled oxidative metabolism of MDSCs and promoted their immune-suppressive function. We also showed that NIC3, a small-molecule inhibitor of NAC1, was able to sensitize mice bearing NAC1-expressing ovarian tumors to anti–PD-1 therapy. Our study reveals a critical role for NAC1 in controlling tumor infiltration of MDSCs and in modulating the efficacy of immune checkpoint blockade therapy. Thus, targeting of NAC1 may be exploited to sensitize ovarian cancer to immunotherapy.
Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase
Authors: Knowles Lynn M. , Wolter Carolin , Linsler Stefan , Müller Simon , Urbschat Steffi , Ketter Ralf , Müller Andreas , Zhou Xiangda , Qu Bin , Senger Sebastian , Geisel Jürgen , Schmidt Tim , Eichler Hermann , Pilch Jan 
Published: November 2024

Abstract
The tumor architecture of high-grade gliomas is shaped by tumor cell necrosis, invasive growth, and the leakage of a fibrin-rich edema from poorly organized tumor blood vessels. In this study, we demonstrate a marked upregulation of clot formation in the interstitial spaces of tumor tissues from patients with glioblastoma (GBM) whereas a tumor-free brain is essentially devoid of fibrin. The accumulation of fibrin in tumor interstitial spaces is functionally relevant as we demonstrate increased infiltration and growth of primary GBM cells after embedding in a 3-dimensional matrix made of fibrin ex vivo. Additionally, we detected accelerated tumor growth after implanting GBM cells together with clotted plasma in brains of immunodeficient mice whereas GBM development in clotting-deficient hemophilia mice was delayed. GBM growth correlated with the outgrowth of invadopodia and their adhesive interactions with the 3-dimensional clot matrix, which was mediated by integrins β1 and β3 and their common downstream target focal adhesion kinase (FAK). Knocking down FAK with CRISPR Cas9 caused an upregulation of p21/p27 cell-cycle inhibitors, strong growth inhibition in cultured GBM cells, and sustained antitumorigenic effects in orthotopic GBM xenografts in vivo. These results go hand in hand with genomic data from The Cancer Genome Atlas that indicate increased clotting activity and reduced patient survival in glioma subgroups with high integrin β1 and β3 expression. We therefore conclude that clotting in glioma interstitial spaces provides tumor cells with a potent proliferative stimulus that can be reversed by targeting the adhesive machinery of GBM cells via inhibition of FAK.

Significance:
High-grade gliomas are associated with intratumoral thrombosis, tumor cell necrosis, and hemorrhage. The resulting blood clot serves as an adhesive matrix for glioma cell integrins that activate FAK. Knocking down FAK with CRISPR cas9, on the other hand, is highly effective at halting GBM growth in mice.
Giving Consent
Authors: Schaber Peter 
Published: November 2024

Abstract
By giving consent, we sometimes give permission or make it the case that we are not wronged. What does it take for an act to be an act of consent? This is the question this paper deals with. The question does not presuppose the view that consent is a communicative act. For those who take it as a mental state, the question is what does it take to express consent? It will be argued that an act is an act of consent if and only if the consent-giver believes she gives someone permission to do or omit something by performing the act. A normative intention is not required for consent. It is further argued that this view also bears on the question of what falls within the scope of consent and shows how it differs from the evidential account advocated by Tom Dougherty. I also argue that the view defended in this paper does not imply – as some think – that the consent-receiver could wrong the consent-giver without being able to know that this is the case.
Tweeting for Influence: Analysing France and China’s Cultural Diplomacy on Social Media, a Mixed Methods Approach
Authors: Meehan Rémi 
Published: November 2024

Abstract
How are states using cultural diplomacy on social media to expand their power? This research analyses over 67,000 tweets from the French and Chinese Ministries of Foreign Affairs (mfa s) as well as their respective state-sponsored cultural networks including Institut Français, Alliance Française, and the Confucius Institutes. Stephen Lukes’ three-dimensional power framework, where cultural authority legitimizes power over others, provides the study’s theoretical basis. In analysing the tweets, I employ a mixed methods approach including vader sentiment analysis, word frequency analysis, and thematic analysis. While both states aim to present their cultures as high-value cultures, the similarities end there. As a liberal democracy, France encourages open expression through its cultural institutions, including discourse critical of France. In contrast, China’s cultural diplomatic messaging is precisely controlled and speaks about China in invariably exalting terms. This study offers evidence that regime type has a powerful effect on cultural diplomatic messaging on social media.
Freedom of Association in Ireland
Authors: Ó Conaill Seán 
Published: November 2024

Abstract
This article examines, the manner in which the right of freedom of association enshrined in Article 40.6.1.iii. It is divided into two parts. Part i outlines the textual basis of the right, its historical development and its nature and scope understood within a unique constitutional context: its scope, relationship with international law, limitations, and relationship with other rights. Part ii then considers some of the rationales for respecting, protecting and promoting freedom of association. It seeks to outline and map the key underpinnings of the approach of Courts, the legislature and scholars when engaging with the right.
Freedom of Association at the echr: a Right in Service of Democracy
Authors: Cahill Maria 
Published: November 2024

Abstract
This article lays out how the right to freedom of association is protected by the European Court of Human Rights interpreting Article 11 of the European Convention on Human Rights. Part i considers how the Court defines “associations” and how it has developed three component aspects of the right: the right to form associations, the right not to be forced to join an association, and the right of the association to organisational autonomy. Part ii outlines the volume and types of disputes that arise, as well as the relationship between freedom of association and other fundamental rights, such as freedom of expression. Part iii reflects on the rationales that the European Court of Human Rights offers for why the right to freedom of association is important, focusing in particular, on its insistence that the right to freedom of association is essential to the proper functioning of democracy.
Freedom of Association in Spain
Authors: Morales Sancho Guillermo A. 
Published: November 2024

Abstract
How is freedom of association protected in Spain? What are the contours developed by the Constitutional and Supreme Courts in dialogue with the Strasbourg and Luxembourg jurisprudence? Have equality and anti-discrimination laws moved the frontiers of associations’ autonomy? These are the questions tackled in this nutshell synthesis of Freedom of Association in Spain.
Freedom of Association in Italy: Genesis, Evolution and Limits of Protection of Associations in the Italian Legal System
Authors: Monti Matteo 
Published: November 2024

Abstract
This paper analyses the different dimensions of freedom of association in Italy. Section 1 introduces the topic and highlights some methodological issues related to comparative law. Section 2 briefly describes the evolution of the provisions protecting freedom of association in Italy from the Albertine Statute to the 1948 Constitution and gives an overview of the various constitutional provisions in which there is an intersection between the issue of freedom of association and the protection of intermediate bodies. Section 3 analyses the entitlement to the right to freedom of association and outlines some past and present derogations for certain categories of public servants, the regulation of constitutionally prohibited associations and the issue of compulsory associations. Section 4 analyses the rights in associations and the rights of associations focusing on compulsory associations and ideologically oriented organisations. Section 5 draws some conclusions and points out some recent legislative trends.
The Purpose and Potential of Freedom of Association in Ethiopia
Authors: Negesse Kelali Kiros 
Published: November 2024

Abstract
In a country where community engagement and social welfare is a predominant phenomenon, constitutional recognition of freedom of association plays a crucial role in guaranteeing a sustained enjoyment of the right. The constitution puts group rights at the forefront of every other right; the nation, nationalities and peoples of the country are expressly recognized as the guardians of the constitution. This article is organized in five parts. In part one, the article addresses the historical and political context of freedom of association in Ethiopia. Part two provides a review of the major contents of national and international legal norms governing freedom of association in Ethiopia. In part three, the article critically evaluates the restrictions to freedom of association in light of the rationale for protection of the right. The last part evaluates the compatibility of judicial decisions in light of the protection of freedom of association in Ethiopia. The article culminates with a conclusion.
Positive Attributable Visual Sources Attenuate the Impact of Trigger Sounds in Misophonia
Authors: Mahzouni Ghazaleh , Welch Moorea M. , Young Michael , Reddy Veda , Samermit Patrawat , Davidenko Nicolas 
Published: November 2024

Abstract
Misophonia is characterized by strong negative reactions to everyday sounds, such as chewing, slurping or breathing, that can have negative consequences for daily life. Here, we investigated the role of visual stimuli in modulating misophonic reactions. We recruited 26 misophonics and 31 healthy controls and presented them with 26 sound-swapped videos: 13 trigger sounds paired with the 13 Original Video Sources (OVS) and with 13 Positive Attributable Visual Sources (PAVS). Our results show that PAVS stimuli significantly increase the pleasantness and reduce the intensity of bodily sensations associated with trigger sounds in both the misophonia and control groups. Importantly, people with misophonia experienced a larger reduction of bodily sensations compared to the control participants. An analysis of self-reported bodily sensation descriptions revealed that PAVS-paired sounds led participants to use significantly fewer words pertaining to body parts compared to the OVS-paired sounds. We also found that participants who scored higher on the Duke Misophonia Questionnaire (DMQ) symptom severity scale had higher auditory imagery scores, yet visual imagery was not associated with the DMQ. Overall, our results show that the negative impact of misophonic trigger sounds can be attenuated by presenting them alongside PAVSs.
Association of greening bacterium with fruit morphological disorder ‘Waywar’ in monsoon cropping of Nagpur mandarin (Citrus reticulata Blanco) grown in central India
Authors: Kalatippi A.S. , Pandey S.K. , Huchche A.D. , Das A.K. , Nair Reena , Jyothsna J. 
Published: November 2024

Abstract
In the Vidarbha region of Maharashtra and the surrounding parts of central India, Waywar (citrus greening bacterium) fruit disorder, also known as wasteful fruit disorder, is a common manifestation of Nagpur mandarin fruit. In Vidarbha, the condition is also known as cock bund, while in China, it is called ‘Red Nose.’ According to early research, this condition is caused by abiotic stress factors, such as poor nutrition, too much moisture in the root zone, and other incorrect cultural practices. Recent research, however, has unequivocally shown that Candidatus Liberobacter asiaticus, the citrus greening bacterium, is responsible for this illness. When compared to normal growing fruits (0.82–0.89), the length to diameter ratio of Waywar fruits at the peak of incidence was reported in the range of 0.95–1.09, indicating their oblong shape. Premature Waywar fruits had higher acidity levels (1.75 to 2.04%) than normal fruits (1.65 to 2.03%) and produced seeds that were not viable. The cultural treatments applied to reduce the ill effects of the disorder improved the physico-chemical characteristics of Nagpur mandarin fruit at the time of harvesting. When compared to the untreated control, foliar spraying with growth regulators 2,4-D (15 ppm) and GA3 (15 ppm) enhanced the amount of fruit retained per plant at harvest. The critical fruit quality parameters like TSS (10.10%) and vitamin C (39.37 mg/100 ml) were highest in GA3 treated fruits. Maximum TSS/Acid ratio (14.00) and minimum acidity (0.69%) were noted with phosphorus applied at three times the RDF level at harvest.
An investigative study to utilise the Fusarium-damaged wheat as a feedstock for the black soldier fly larvae (Hermetia illucens)
Authors: Kumar V. , Ochoa-Sanabria C. , Tanaka T. 
Published: November 2024

Abstract
This study investigated Fusarium-damaged wheat kernels (FDK) as a potential feeding substrate for black soldier fly larvae (Hermetia illucens; BSFL). Fusarium-damaged kernels are considered unsuitable for food and feed due to the presence of mycotoxins. Mycotoxins, like deoxynivalenol (DON), pose health risks when consumed by animals at concentrations exceeding the limits established by the Canadian Food Inspection Agency. However, BSFL have shown higher tolerance to mycotoxins, suggesting that FDK may be used as a feeding substrate for BSFL intended for animal consumption. To assess this, three FDK-based diets with varying concentrations of DON (4.49 ± 0.08 ppm, 6.04 ± 0.02 ppm, and 6.83 ± 0.04 ppm) and a healthy wheat-based diet (0 ppm DON; control diet) were formulated to grow the larvae. The diets were fed to larvae to assess their preference based on DON concentration. Concurrently, the accumulation of DON in BSFL biomass and its effects on growth parameters were evaluated. The larvae showed no preference for any DON concentration. The DON levels accumulated in the BSFL biomass were minimal, regardless of the DON concentration in the feed (), with the highest recorded at 0.87 ± 0.04 ppm compared to 6.83 ± 0.06 ppm in the diet. Despite the potential harm of FDK to animals, the growth parameters of BSFL improved, with larvae on FDK-based diets reaching a live body weight of 185.0 ± 3.2 mg compared to 177.6 ± 4.2 mg for the control on Day 15. The nutritional profile remained nearly identical across all DON concentrations (∼41% crude lipid and ∼39% crude protein in dried biomass). These findings suggest that BSFL raised on FDK-based diets can be used effectively for feed purposes.
Beyond the Ultima Thule on the Open Sea: the Chinese and Western Encounters in Trans-cultural Literary Perspectives
Authors: Wang Zhaoyu 
Published: November 2024

Abstract
Utilizing ancient Chinese, Latin, and Greek literary sources, this paper examines the interconnected evidence relating to maritime trade from the late 2nd century bc to the 6th century ad. By analyzing the similarities and differences found in texts regarding regions from the South China Sea to the Indian Ocean, the paper explores aspects that transcend the geographical boundaries of both Chinese and Greco-Roman civilizations, with the goal of throwing light on the flourishing of Sino-Roman maritime trade during late antiquity.
Vertical Sectioning of the Cartilaginous Vault for Rhinoplasty: Technique and Assessment
Authors: Boeckmann Jacob , Hakimi Amir A. , Martin Elaine , Merna Catherine , Hu Allison C. , Foulad Allen , Wong Brian J. F. 
Published: November 2024

Objectives: To describe and assess the vertical sectioning technique for mid vault dissection in patients undergoing primary and secondary rhinoplasty. Methods: A retrospective review of 208 patients undergoing primary or revision rhinoplasty utilizing the vertical sectioning technique. The Nasal Obstruction Symptom Evaluation (NOSE) scale was administered to patients pre- and post-operatively. A detailed description of the technique is presented. Results: Mean follow up was 8.59 ± 7.30 months. Spreader grafts were used in 185 patients (89%), upper lateral cartilage autospreader flaps were utilized in 16 patients (7.7%), and both spreader grafts and autospreader flaps were used in 7 patients (3.4%). Ten primary rhinoplasty patients (4.8%) and 3 revision rhinoplasty patients (4.5%) complained of functional nasal obstruction post-operatively. At time of last follow-up, there was a significant improvement in mean NOSE scores for patients receiving spreader grafts (71.2 ± 21.4-21.5 ± 2.8, P < .001), autospreader flaps (69.2 ± 25.9-17.2 ± 21.5, P < .001), and both (57.9 ± 35.0-26.1 ± 20.2, P = .03). Conclusion: The vertical sectioning technique respects the anatomic, functional, and esthetic relationship of the middle vault, while maximizing cartilage preservation.