bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studi Literatur: Model Pembelajaran Quantum Teaching Dalam Meningkatkan Keberanian Berbicara Siswa Menggunakan Media Realia
Authors: Adikalan Thoriq Hasan 
Published: August 2019

One of the reasons for the low learning outcomes is that the learning method used by the teacher does not involve student activity and also the lack of care from the teacher to provide media in learning. The courage to speak a student is very important and needed in a class discussion, because with a student daring to speak in front of the class he has been found as an active student. The purpose of this article is to discuss the application of realia media in increasing the courage to speak students during learning or class discussion so as to increase student activity. Realia media is an object that can be seen, heard or experienced by students so as to provide experience directly to them. Quantum Teaching is an effective and fun and not boring learning model. Quantum Teaching learning steps are known as TANDUR: (1) Grow (2) Natural (3) Rename (4) Demonstration (5) Repeat and (6) Celebrate. Relevant research results show that Media Realia is able to increase student activity in asking, discussing, and expressing their opinions.

Keyword: Quantum Teaching, Media Realia, Speak.
Demonstration Learning Berbasis Video Pembelajaran dalam Meningkatkan Hasil Belajar IPA Siswa SMP
Authors: Baity Wardah Laily Nur 
Published: August 2019

Education is guidance carried out by educators consciously on the physical and spiritual development of students as an effort to mature a person through guidance and training. Education in Indonesia continues to grow in line with the times. So that a teacher is required to provide material not only using the lecture method but using other learning methods. The purpose of this study is to find out about improving student learning outcomes by using a demonstration learning method based on learning videos. With the use of student learning videos it is easier to understand the material being taught so that it can link material taught with natural phenomena. In addition students do not feel bored when they are in class and have a high curiosity so students actively ask in class. The use of video learning also improves student learning outcomes.

Kata Kunci: demonstration method, learning achievement and learning video
Penerapan Model Pembelajaran IPA Dengan Menggunakan Metode Keterampilan Berfikir Kreatif Siswa Dan Pemahaman Konsep IPA Siswa SMP
Authors: Yolanda Silvia Bella 
Published: August 2019

Abstrak: Kurang terlibatnya seorang peserta didik dalam suatu proses pembelajaran atau dalam kata lain yang bersifat eacher center, hal tersebuat dapat menyebabkan seorang anak didik atau ppeserta didik mengalami rendahnya daya untuk berpikir kreatif, baik dari segi intelektual, konsentrasi, percaya diri dan kepribadian. Serta didalam suatu proses pembelajaran terdapat masalah mengenai kurangnya atau rendahnya pemahaman siswa terhadap konsep mata pelajaran IPA. Penelitian ini dibuat guna untuk meningkatkan penerapan model dalam pembelajaran IPA siswa SMP yang menggunakan metode keterampilan berfikir kreatif siswa dan pemahaman konsep IPA, serta melihat bahwa disekolah sudah menerapkan model pembelajaran terseburt atau belum. Dalam penelitian ini menggunakan metode analisis deskriptif dengan pengambilan data melalui proses wawancara tes mengenai materi pembelajaran dengan beberapa siswa SMP kelas IX. Sampel penelitian ini diambil dari SMP Negeri 3 Rambipuji dengan menggunakan 25 siswa. Dari hasil penelitian yang telah dilakukan melalui tes wawancara dapat dinyatakan bahwasanya 70% dari siswa SMP Negeri 3 Rambipuji sudah menjawab dengan baik dan dalam hal berfikir kreatif dan pemahaman konsepnya sudah baik. Sehingga dapat dinyatakan bahwasanya penerapan model pembelajaran IPA dengan menggunakan metode berfikir kreatif dan metode pemahaman konsep sangat penting dan berpengaruh dalam kegiatan pembelajaran.

Kata kunci: Keterampilan Berfikir Kreatif Siswa, Pemahaman Konsep IPA
Evaluation of the effectiveness and tolerance of tetracosactide in the treatment of post-dural puncture headaches (ESYBRECHE): A study protocol for a randomized controlled trial
Authors: Depaulis Celia , Steer Nadia , Chassard Dominique , Aubrun Frederic 
Published: August 2019

Abstract
Background

Post-dural puncture headache (PDPH) is one of the most common complications of neuraxial anesthesia. It limits patients’ general activity and increases hospital length of stay and use of care. It is particularly disabling during the postpartum period, when mothers have to take care of their child. Epidural blood patch is the standard treatment of PDPH. However, it is an invasive procedure that may result in rare but serious complications. Recent evidence suggests the effectiveness of adrenocorticotropic hormone (ACTH) in the management of PDPH. The aim of this study is to assess the efficacy and safety of tetracosactide (Synacthen®), a synthetic analogue of ACTH, in the treatment of PDPH in patients who received neuraxial anesthesia during labor.

Method

This is a randomized, double-blinded, placebo-controlled, parallel-arm trial, performed in two French university hospitals. Eligible patients are those suffering from postpartum PDPH, who are randomized to receive either 1 mg of tetracosactide intravenously over 20 min, or 0.9% saline (placebo). The primary endpoint of the study is the rate of epidural blood patch within a 15-day follow-up period. Duration of headache, intensity of pain, reduction of general activity, increase of hospital length of stay, adverse events, analgesic use (type and duration), and number of blood patches per patient in each group are recorded.

Discussion

We expect a decrease in the use of epidural blood patch in those who receive tetracosactide, thus indicating a decrease in PDPH symptoms in these patients. This will define the therapeutic success of tetracosactide and the possibility to use this treatment as a noninvasive alternative to blood patch in the treatment of PDPH.
Exploring the utility of the Pain Attitudes and Beliefs Scale with general practitioners and physiotherapists in the context of osteoarthritis: a cross-sectional observational study
Authors: O'Brien Daniel William , Clair Valerie Wright St , Siegert Richard , Bassett Sandra 
Published: August 2019

Abstract
Background

Conservative treatments for hip and knee joint osteoarthritis are underused despite the known benefits. Adherence to conservative treatments is poor and affected by people’s health, illness and treatment beliefs. Clinicians’ beliefs can also affect the advice and education given to patients. Few studies have explored general practitioners’ (GPs; primary care physicians) and physiotherapists’ osteoarthritis-related health, illness and treatment beliefs. In addition, limited questionnaires are available to explore this phenomenon. This study aimed to identify if GPs and physiotherapists had beliefs about osteoarthritis that fit better with biomedical or biopsychosocial models, and explore the utility of the Pain Attitudes and Beliefs Scale for Physiotherapists (PABS-PT) adapted for osteoarthritis.

Methods

This study used a cross-sectional observational design. Data were collected anonymously from GPs and physiotherapists using an online survey. The survey included a study-specific demographic and occupational characteristics questionnaire and the PABS-PT questionnaire adapted for osteoarthritis. All data were analysed using descriptive statistics. PABS-PT data also underwent principal factor analysis.

Results

In total, 295 clinicians (87 GPs, 208 physiotherapists) participated in this study. The principal factor analysis identified two factors or subscales (biomedical and behavioural), with Cronbach’s alphas of 0.84 and 0.44, respectively. Participants scored higher on the behavioural (3.85) than the biomedical (2.78) beliefs subscale.

Conclusions

The results suggest clinicians’ osteoarthritis beliefs are broadly more behavioural (biopsychosocial) than biomedical in orientation. However, the poor internal consistency of the behavioural subscale suggests the PABS-PT is not suitable for adaptation for osteoarthritis.
Identification of Transcription Factors related to Diabetic Tubulointerstitial Injury
Authors: Liu Jialu , Duan Guangzhong , Yang Wenxia , Zhang Shumin , Liu Fuyou , Peng Youming , Sun Lin , Liu Yu , Xiao Li 
Published: August 2019

Abstract
Background: Diabetic nephropathy (DN) is a main cause of chronic renal failure. Despite decades of extensive study, the molecular mechanisms underlying diabetic tubulointerstitial injury remain unclear. We aim to identify key transcription factor genes involved in diabetic tubulointerstitial injury.
Methods: A microarray dataset (GSE30122) from Gene Expression Omnibus (GEO) was downloaded. A total of 38 transcription factor genes based on 166 differentially expressed genes(DEGs) were identified by UCSC_TFBS.
Results: The regulatory network showed connections between top 10 transcription factors and their target DEGs. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of targeted DEGs indicated that extracellular space, extracellular exosome, cell surface and complement and coagulation cascades were most significantly enriched. Utilizing Nephroseq v5 online platform, the mRNA expression pattern analysis of transcription factor genes demonstrated that mRNA expression of CDC5, CEBPA, FAC1, HFH1, IRF1, NFE2 and TGIF1 increased in renal tubulointerstium of DN patients compared with normal controls while that of CEBPB and FOXO4 decreased in renal tubulointerstium of DN patients compared with normal controls.Correlation analysis between mRNA expression of transcription factor genes in renal tubulointerstium and clinical features showed that AP1, BACH1, CDC5, FAC1, FOXD1, FOXJ2, FOXO1, FOXO4, HFH1, IRF1, POU3F2, SOX5, SOX9, RSRFC4, S8 and TGIF1 may be related to diabetic tubulointerstitial injury.
Conclusions: 1)CDC5, FAC1, FOXO4, HFH1, IRF1 and TGIF1 may be key transcription factor genes. 2)Transcription factors involved in diabetic tubulointerstitial injury may become prospective targets for diagnosis and treatment of DN.
Application of subjective and objective tools for the evaluation of the articulatory organs among patients with amyotrophic lateral sclerosis
Authors: Pawlukowska Wioletta , Baumert Bartłomiej , Gołąb-Janowska Monika , Meller Agnieszka , Machowska-Sempruch Karolina , Wełnicka Agnieszka , Paczkowska Edyta , Rotter Iwona , Machaliński Bogusław , Nowacki Przemysław 
Published: August 2019

Abstract
Introduction

Amyotrophic lateral sclerosis (ALS) is a fatal degenerative disease of a rapid course. In 25% of ALS sufferers, speech disorders occur as prodromal symptoms of the disease. Impaired communication affects physical health and has a negative impact on mental and emotional condition. In this study, we assessed which domains of speech are particularly affected in ALS. Subsequently, we estimated possible correlations between the ALS patients’ subjective perception of their speech quality and an objective assessment of the speech organs carried out by an expert.

Methods

The study group consisted of 63 patients with sporadic ALS. The patients were examined for articulatory functions by means of Voice Handicap Index (VHI) and the Frenchay Dysarthria Assessment (FDA).

Results

On the basis of the VHI scores, the entire cohort was divided into 2 groups: group I (40 subjects) with mild speech impairment, and group II (23 subjects) displaying moderate and profound speech deficits. The deficits were observed more frequently in men (60.31%). In an early phase of ALS, changes were typically reported in the tongue, lips and soft palate. The FDA and VHI-based measurements revealed a high, positive correlation between the objective and subjective evaluation of articulation quality.

Conclusion

Deterioration of the articulatory organs resulted in the reduction of social, physical and emotional functioning. The highly positive correlation between the VHI and FDA scales seems to indicate that the VHI questionnaire may be a reliable, self-contained tool for monitoring the course and progression of speech disorders in ALS.
Optimum Nitrogen Rates for Maize and Wheat in North Carolina
Authors: Austin Robert , Osmond Deanna , Shelton Shelby 
Published: August 2019

Nitrogen decision making and the selection of the “right” N rate in wheat (Triticum aestivum L.) and maize (Zea mays L.) are difficult due to complex interactions in the N cycle with weather, management, and genetics. An adaptive management approach utilizing farmer networks and participatory learning was established to refine N rate decisions. On‐farm trials were established to reflect grower N rate with additional treatments of ±25% N. In 79 site‐years of wheat, N−25%, Nstd, and N+25% rate treatments were best in 37, 35, and 28% of the trials, respectively. In 100 site‐years of maize, N−25%, Nstd, and N+25% rate treatments were best in 58, 30, and 12% of the trials, respectively. Grower’s selected N rates in wheat were similar to recommendations from the North Carolina Realistic Yield Expectation (RYE) database while maize N rates were an average 48 kg ha−1 higher; however, N−25% rates, which were best 58% of the time, were similar to RYE N rate. Doppler‐based estimates of total precipitation from the National Weather Center explained 90% of the average maize yield variability. However, site‐yield was independent of location, N rate, and total precipitation. Measures of performance (N factor productivity and N balance) varied with achieved yields but indicate most growers apply N adequate to maintain organic N lost through mineralization. Results suggest that improved approaches to N rate selection and N efficiency will likely require in‐season adjustments to yield‐based N rates that incorporate local management and environmental conditions throughout the growing season.Core Ideas

Yield level and response is independent of location, N rate, and total precipitation.
Doppler‐based rainfall estimates help explain seasonal trends in yield.
Growers often select N rates greater than recommended for maize but not wheat.
Asymbiotic Nitrogen Fixation is Greater in Soils under Long‐Term No‐Till Versus Conventional Tillage
Authors: Franzen David W. , Inglett Patrick , Gasch Caley K. 
Published: August 2019

A series of N‐rate experiments previously conducted in spring wheat, corn, and sunflower in North Dakota indicated that less N was required when fields were in six years or more continuous no‐till compared to conventional till. The objective of this study was to determine whether part of the reason for the decreased requirement for N was the greater activity of asymbiotic N‐fixing organisms. Twelve paired‐samplings were conducted in 2018. A surface 0‐ to 5‐cm deep sample was obtained in a long‐term no‐till field directly across the fence or road from a similar soil in conventional till. Samples were incubated in an acetylene‐reduction procedure to estimate N fixation rate. Ten of twelve paired samplings had greater asymbiotic N fixation compared to the conventional till counterpart. This indicates that long‐term no‐till soils support greater N production from soil microorganisms than conventional till soils, which would result in lower input costs to no‐till farmers.Core Ideas
Microbial communities are different between conventional till and no‐till managed soils.
Asymbiotic N‐fixation was greater in farmer‐managed no‐till than neighboring conventional till.
N recommendations in long‐term continuous no‐till should be separate from conventional till N recommendations.
Effective water quantity of multi-source water recharging aquifers in Yufuhe River based on groundwater and surface water semi-coupled modelling
Authors: Li Wenliang , Sun Qing , Wang Weiping , Qu Shisong , Zhang Zhengxian , Xu Qiaoyi 
Published: August 2019

AbstractWith rapid urbanisation, a karst water recharge area of the Jinan spring catchment was damaged. Thus, managed aquifer recharge projects were built in the western Jinan spring catchment to protect the water supply of the spring. Yufuhe River was selected as the study area to compute the effective recharge rate into karst aquifers. This strong seepage zone has a large gradient and undergoes a specific hydrogeological condition in which two strata of a gravel layer and limestone change to three strata of gravel, impermeable clay shale and limestone at the open window of the karst aquifers. A hydraulic model called HEC-RAS was applied to simulate the river stage, and a numerical groundwater model called HYDRUS-3D was adopted to simulate the groundwater mound dynamics and estimate river flow seepage into the aquifers. The effective recharge rates are 64.9%, 65.2% and 68.1% when the buried depths of groundwater are 40, 30 and 25 m. An analysis of the electric conductivity, water table, temperature and water volume data found an effective recharge rate of 68.3%. Results of field monitoring confirmed the accuracy of the numerical simulation and showed that most of the recharged water in the study reach can be effectively recharged into the karst aquifers.
Particular internal recirculation frequency scope for enhancing denitrifying phosphorus removal in an oxidation ditch
Authors: Wang Shao Po , Yu Jing Jie , Su Fan Kai , Gao Fu , Sun Li Ping 
Published: August 2019

AbstractThis study investigated the influence of the unique internal recirculation characteristics of an oxidation ditch (OD) system, namely, the internal recirculation frequency (IRF) on denitrifying phosphorus removal (DNPR). The ratios of denitrifying polyphosphate-accumulating organisms (DPAOs) to polyphosphate-accumulating organisms (PAOs) under different IRF conditions were measured using a batch experiment. On this basis, the variation of nutrient transformations were studied using the IRF changes by the mass balance method. The results showed that for the OD system that had an anaerobic zone upstream from the circular corridor and set anoxic and aerobic zones along the circular corridor, when the IRF was between 3.4 h−1 and 7.5 h−1, the DPAOs/PAOs ratio reached about 50%. Approximately 20% of the total phosphorus (TP) was removed and over 11% of the total nitrogen (TN) was transformed into nitrogen gas by the DNPR process, and meanwhile the total removal efficiencies of the TP and TN were over 93% and 80%. When the IRF was greater than 11.5 h−1, the TN removal efficiency decreased significantly, and this was not conducive to simultaneous nitrogen and phosphorus removal. The results indicated that OD process would possess a better DNPR potential if the IRF was controlled within the proper scope.
Level of Knowledge About Alzheimer's Disease Among Nursing Staff in Suzhou and its Influencing Factors
Authors: Lin Lu , Lv Shujiao , Liang Jinghong , Li Huiling , Xu Yong 
Published: August 2019

Background:With the rapid aging process, an increasing number of individuals will be living with dementia worldwide. A good mastery of knowledge about Alzheimer's Disease (AD) by medical staff has been reported to improve the outcome of patients with AD, making it necessary to assess the level of AD knowledge among nursing staff and address their knowledge deficits in order to upgrade the quality of care and improve quality of life for AD patients.Objective:To assess the level of AD knowledge among nursing staff in Suzhou, using the Alzheimer's Disease Knowledge Scale (ADKS), and analyze its influencing factors.Methods:Nursing staff working in healthcare institutes such as hospitals, community centers, nursing homes, etc. in all the six districts of Suzhou City were selected by convenience sampling. A selfdesigned questionnaire was used to collect general information of the participants, including gender, age, education, professional title, workplace, AD-related training, contact with AD patients, experience in caring for AD patients, etc., and the ADKS scale was used to assess their level of AD knowledge.Results:A total of 1102 in-service nursing staff in Suzhou were included in the study. Univariate analysis showed that age, education, professional titles, bias towards AD patients, AD-related training, contact with AD patients, experience in caring for AD patients were the influencing factors of the total ADKS score; multivariate analysis indicated that age, bias towards AD patients, and contact with AD patients are independent influencing factors of the level of AD knowledge among nursing staff in Suzhou.Conclusion:Mastery of AD knowledge among the nursing staff in Suzhou is not satisfactory. It is urgent to change the nursing staff’s negative attitude towards AD and put into effect AD-related health education and training courses so that nursing staff can upgrade their level of AD knowledge and provide better care in order to improve the quality of life for AD patients.
Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy
Authors: Sun Xiao-Ying , Dong Quan-Xiu , Zhu Jie , Sun Xun , Zhang Li-Fan , Qiu Mandy , Yu Xiao-Lin , Liu Rui-Tian 
Published: August 2019

Background:Alzheimer’s Disease (AD) is characterized by the presence of extracellular amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles assembled by the microtubuleassociated protein tau. Increasing evidence demonstrated that tau pathology played an important role in AD progression. Resveratrol (RSV) has previously proved to exert neuroprotective effect against AD by inhibiting Aβ generation and Aβ-induced neurocytotoxicity, while its effect on tau pathology is still unknown.Method:The effect of RSV on tau aggregation was measured by Thioflavin T fluorescence and Transmission electron microscope imaging. The effect of RSV on tau oligomer-induced cytotoxicity was assessed by MTT assay and the uptake of extracellular tau by N2a cells was determined by immunocytochemistry. 6-month-old male PS19 mice were treated with RSV or vehicle by oral administration (gavage) once a day for 5 weeks. The cognitive performance was determined using Morris water maze test, object recognition test and Y-maze test. The levels of phosphorylated-tau, gliosis, proinflammatory cytokines such as TNF-α and IL-1β, and synaptic proteins including synaptophysin and PSD95 in the brains of the mice were evaluated by immunoblotting, immunostaining and ELISA, respectively.Results:RSV significantly inhibited tau aggregation and tau oligomer-induced cytotoxicity, and blocked the uptake of extracellular tau oligomers by N2a cells. When applied to PS19 mice, RSV treatment effectively rescued cognitive deficits, reducing the levels of phosphorylated tau, neuroinflammation and synapse loss in the brains of mice.Conclusion:These findings suggest that RSV has promising therapeutic potential for AD and other tauopathies.