bluuebunny/crossref_metadata_2025_split huggingface dataset:
A revised order of subunits in mammalian septin complexes
Authors: Mendonça Deborah C. , Macedo Joci N. , Guimarães Samuel L. , Barroso da Silva Fernando L. , Cassago Alexandre , Garratt Richard C. , Portugal Rodrigo V. , Araujo Ana P. U. 
Published: October 2019

AbstractSeptins are GTP binding proteins considered to be novel components of the cytoskeleton. They polymerize into filaments based on hexameric or octameric core particles in which two copies of either three or four different septins, respectively, assemble into a specific sequence. Viable combinations of the 13 human septins are believed to obey substitution rules in which the different septins involved must come from distinct subgroups. The hexameric assembly, for example, has been reported to be SEPT7–SEPT6–SEPT2–SEPT2–SEPT6–SEPT7. Here, we have replaced SEPT2 by SEPT5 according to the substitution rules and used transmission electron microscopy to demonstrate that the resulting recombinant complex assembles into hexameric particles which are inverted with respect that predicted previously. MBP‐SEPT5 constructs and immunostaining show that SEPT5 occupies the terminal positions of the hexamer. We further show that this is also true for the assembly including SEPT2, in direct contradiction with that reported previously. Consequently, both complexes expose an NC interface, as reported for yeast, which we show to be more susceptible to high salt concentrations. The correct assembly for the canonical combination of septins 2‐6‐7 is therefore established to be SEPT2–SEPT6–SEPT7–SEPT7–SEPT6–SEPT2, implying the need for revision of the mechanisms involved in filament assembly.
Bioequivalence Study of 2 Formulations of Rivaroxaban, a Narrow‐Therapeutic‐Index Drug, in Healthy Chinese Subjects Under Fasting and Fed Conditions
Authors: Ding Sijia , Wang Lu , Xie Lijun , Zhou Sufeng , Chen Juan , Zhao Yuqing , Deng Wenjie , Liu Yun , Zhang Hongwen , Shao Feng 
Published: October 2019

AbstractThis study aimed to evaluate the bioequivalence (BE) of 2 formulations of the 10‐mg rivaroxaban tablet. The study was a randomized, open‐label, 4‐period, crossover study that included 28 healthy subjects in fasting or fed conditions. The pharmacokinetic parameters were determined based on the concentrations of rivaroxaban using high‐performance liquid chromatography with a tandem mass spectrometer detector. In each of the 4 study periods with fasting or fed conditions, a single dose of test or reference product was administered. Rivaroxaban concentrations in plasma were determined using a validated liquid chromatography with a tandem mass spectrometer detector method. The pharmacokinetic parameters assessed were the area under the plasma concentration‐time curve (AUC0‐t, AUC0‐∞), the peak plasma concentration of the drug (Cmax), time to achieve Cmax, elimination half‐life, within‐subject variability of test drug, and within‐subject variability of reference drug. The geometric mean ratio (90%CI) of the test drug/reference drug for rivaroxaban was 90.38% to 103.60% for AUC0‐t in fasting conditions and 90.13% to 100.42% in fed conditions. The AUC0‐∞s were 89.94% to 102.50% and 90.14% to 100.45% under fasting and fed conditions, respectively. The Cmax values were 90.58% to 105.01% and 96.36% to 108.07% in these 2 conditions, respectively. All 90%CIs for test drug/reference drug geometric mean ratio were ≤2.5. The 90%CIs for test/reference AUC ratio and Cmax ratio were within the acceptable range for BE. There were no adverse events encountered during this BE study. The study's results indicated that the 2 formulations of the rivaroxaban tablet were bioequivalent.
In Situ Methylation Transforms Aggregation‐Caused Quenching into Aggregation‐Induced Emission: Functional Porous Silsesquioxane‐Based Composites with Enhanced Near‐Infrared Emission
Authors: Yan Yehao , Laine Richard M. , Liu Hongzhi 
Published: October 2019

AbstractMethylation of TPA‐DCM (2‐(2,6‐bis‐4‐(diphenylamino)stryryl‐4H‐pyranylidene)malononitrile) that exhibits aggregation‐caused quenching (ACQ) results in the fluorophore M‐TPA‐DCM (2‐(2,6‐bis((E)‐4‐(di‐p‐tolylamino)‐styryl)‐4H‐pyran‐4‐ylidene]malononitrile) that shows aggregation‐induced emission (AIE) and NIR fluorescence and has a conjugated “D‐π‐A‐π‐D” electronic configuration. Friedel‐Crafts reaction of TPA‐DCM and octavinylsilsesquioxane (OVS) resulted in a family of porous materials (TPAIEs) that contain the M‐TPA‐DCM motif and show large Stokes shifts (180 nm), NIR emission (670 nm), tunable porosity (SBET from 160 to 720 m2 g−1, pore volumes of 0.13–0.55 cm3 g−1), as well as high thermal stability (400 °C, 5 % mass loss, N2). As a simple test case, one of TPAIE materials was used to sense Ru3+ ions with high selectivity and sensitivity.
2 D Hybrid of Ni‐LDH Chips on Carbon Nanosheets as Cathode of Zinc–Air Battery for Electrocatalytic Conversion of O2 into H2O2
Authors: Huang Junheng , Chen Junxiang , Fu Changle , Cai Pingwei , Li Yan , Cao Linlin , Liu Wei , Yu Peng , Wei Shiqiang , Wen Zhenhai , Li Jinghong 
Published: October 2019

AbstractIt remains great challenge to develop precious‐metal‐free electrocatalysts to implement high‐activity electrochemical conversion of O2 into value‐added hydroperoxide species (HO2−), which are vulnerable when exposed to various transition‐metal‐based catalysts. A strategy based on steric hindrance and layered nickel‐based layered double hydroxide (Ni‐LDH) induction has been developed for one‐pot inlaying high‐density ultrathin 2 D Ni‐LDH chips on in situ‐grown carbon nanosheets (Ni‐LDH C/CNSs). The resulting material exhibits high electrocatalytic selectivity with a faradaic efficiency up to 95 % for oxygen reduction into peroxide and attains a fairly high mass activity of approximately 22.2 A g−1, outperforming most metal‐based catalysts reported previously. Systematic studies demonstrate that the greatly increased defect concentration at Ni edge sites of Ni‐LDH chips results in more active sites, which contributes a favorable thermodynamically neutral adsorption of OOH* and adsorbed H2O2 molecules relatively weakly. Additionally, the modified CNSs effectively suppress H2O2 decomposition and avoid O−O bond cleavage to produce H2O by steric effects. The synergistic effect of CNSs and Ni‐LDH chips therefore leads to high activity and high selectivity in a two‐electron pathway. A proof‐of‐concept zinc–air fuel cell is proposed and set up to demonstrate the feasibility of green synthesis of peroxide, generating an impressive H2O2 production rate of 5239.67 mmol h−1 gcat.−1.
Strongly Coupled MoS2 Nanocrystal/Ti3C2 Nanosheet Hybrids Enable High‐Capacity Lithium‐Ion Storage
Authors: Hu Zhongli , Kuai Xiaoxiao , Chen Juntong , Sun Pengfei , Zhang Qiaobao , Wu Hong‐Hui , Zhang Li 
Published: October 2019

AbstractSmart integration of transition‐metal sulfides/oxides/nitrides with the conductive MXene to form hybrid materials is very promising in the development of high‐performance anodes for next‐generation Li‐ion batteries (LIBs) owing to their advantages of high specific capacity, favorable Li+ intercalation structure, and superior conductivity. Herein, a facile route was proposed to prepare strongly coupled MoS2 nanocrystal/Ti3C2 nanosheet hybrids through freeze‐drying combined with a subsequent thermal process. The Ti3C2 host could enhance the reaction kinetics and buffer the volume change of MoS2 at a low content (8.87 wt %). Thus, the MoS2/Ti3C2 hybrids could deliver high rate performance and excellent cycling durability. As such, high reversible capacities of 835.1 and 706.0 mAh g−1 could be maintained after 110 cycles at 0.5 A g−1 and 1390 cycles at 5 A g−1, respectively, as well as an outstanding rate capability with a capacity retention over 65.8 % at 5 A g−1. This synthetic strategy could be easily extended to synthesize other high‐performance MXene‐supported hybrid electrode materials.
Introduction to a special issue on eating disorders and related symptomatology in male populations
Authors: Murray Stuart B. , Griffiths Scott , Lavender Jason M. 
Published: October 2019

AbstractObjectiveIt is our sincere pleasure to introduce a special issue of the International Journal of Eating Disorders focused on eating disorders and related symptoms in male populations.MethodContributions focused on three main themes among male populations: (a) the nature of eating disorder symptoms and recovery; (b) long‐term outcomes following eating disorders treatment; and (c) muscularity‐oriented symptoms of eating pathology.ResultsThe contributions to this special issue highlight the importance of better understanding how eating disorder symptoms manifest, may be maintained, and respond to treatment among male populations. Findings across the articles demonstrate some similarities between male and female samples with respect to core eating disorder symptoms, as well as important differences, particularly with respect to muscularity‐oriented disordered eating. Findings related to treatment outcome also highlight the suboptimal long‐term remission rates and elevated mortality among male inpatients with eating disorders.DiscussionThe diverse range of samples, methodologies, and research questions addressed within this collection of papers demonstrates the breadth of the important scientific work on this topic. As eating disorders and related symptoms in male populations continue to be underrecognized and underserved, we hope that this special issue will encourage further high‐quality clinical research in this area.
Temporal Trends (1981–2013) of Per- and Polyfluoroalkyl Substances and Total Fluorine in Baltic cod (Gadus morhua)
Authors: Schultes Lara , Sandblom Oskar , Broeg Katja , Bignert Anders , Benskin Jonathan P. 
Published: October 2019

Abstract
Temporal trends from 1981 to 2013 of 28 per- and polyfluoroalkyl substances (PFASs) were investigated in liver tissue of cod (Gadus morhua) sampled near southeast Gotland, in the Baltic Sea. A total of 10 PFASs were detected, with ∑28PFAS geometric mean concentrations ranging from 6.03 to 23.9 ng/g ww. Perfluorooctane sulfonate (PFOS) was the predominant PFAS, which increased at a rate of 3.4% per year. Most long-chain perfluoroalkyl carboxylic acids increased at rates of 3.9 to 7.3% per year except for perfluorooctanoate (PFOA), which did not change significantly over time. The perfluoroalkyl acid precursors perfluorooctane sulfonamide (FOSA) and 6:2 fluorotelomer sulfonic acid were detected, of which the former (FOSA) declined at a rate of –4.4% per year, possibly reflecting its phase-out starting in 2000. An alternate time trend analysis from 2000 to 2013 produced slightly different results, with most compounds increasing at slower rates compared to the entire study period. An exception was perfluorohexane sulfonate (PFHxS), increasing at a faster rate of 3.7% measured from 2000 on, compared to the 3.0% per year measured starting from 1981. Analysis of the total fluorine content of the samples revealed large amounts of unidentified fluorine; however, its composition (organic or inorganic) remains unclear. Significant negative correlations were found between concentrations of individual PFASs (with the exception of PFOS) and liver somatic index. In addition, body length was negatively correlated with PFOA and perfluorononanoate, but positively correlated with perfluorododecanoate (PFDoDA) and FOSA. Additional studies on endocrine, immunological, and metabolic effects of PFAS in marine fish are essential to assess the environmental risk of these substances. Environ Toxicol Chem 2020;39:300–309. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
Abstract
Increasing trends for most long-chain perfluoroalkyl acids and declining FOSA concentrations were detected in Baltic cod liver, along with correlations of certain PFASs with body length and liver somatic index.
Targeting Bortezomib to Bone Increases Its Bone Anabolic Activity and Reduces Systemic Adverse Effects in Mice
Authors: Wang Hua , Zhang Hengwei , Srinivasan Venkat , Tao Jianguo , Sun Wen , Lin Xi , Wu Tao , Boyce Brendan F , Ebetino Frank H , Boeckman Robert K , Xing Lianping 
Published: October 2019

ABSTRACT
Bortezomib (Btz) is a proteasome inhibitor approved by the FDA to treat multiple myeloma. It also increases bone volume by promoting osteoblast differentiation and inhibiting osteoclastogenesis in mice. However, Btz has severe systemic adverse effects, which would limit its use as a bone anabolic agent. Here, we designed and synthesized a bone-targeted form of Btz by conjugating it to a bisphosphonate (BP) with no antiresorptive activity. We report that BP-Btz inhibited osteoclast formation and bone resorption and stimulated osteoblast differentiation in vitro similar to Btz. In vivo, BP-Btz increased bone volume more effectively than Btz in three mouse models: untreated wild-type mice, mice with ovariectomy, and aged mice with tibial factures. Importantly, BP-Btz had significantly less systemic side effects than Btz, including less thymic cell death, sympathetic nerve damage, and thrombocytopenia, and it improved survival rates in aged mice. Thus, BP-Btz represents a novel anabolic agent to treat conditions, such as postmenopausal and age-related bone loss. Bone targeting is an attractive approach to repurpose approved drugs to treat skeletal diseases. © 2019 American Society for Bone and Mineral Research. © 2019 American Society for Bone and Mineral Research.
Inflammasomes in the pathophysiology of autoinflammatory syndromes
Authors: Tartey Sarang , Kanneganti Thirumala-Devi 
Published: October 2019

Abstract
Inflammasomes are a specialized group of intracellular sensors that are key components of the host innate immune system. Autoinflammatory diseases are disorders of the innate immune system that are characterized by recurrent inflammation and serious complications. Dysregulation of the inflammasome is associated with the onset and progression of several autoinflammatory and autoimmune diseases, including cryopyrin-associated periodic fever syndrome, familial Mediterranean fever, rheumatoid arthritis, and systemic lupus erythematosus. In this review, we discuss the involvement of various inflammasome components in the regulation of autoinflammatory disorders and describe the manifestations of these autoinflammatory diseases caused by inflammasome activation.
Comparative study and multiple linear regression analysis for assessment of chromatographic behavior of structurally related β‐blockers on different stationary phases
Authors: Faried Abdel Hakiem Ahmed , Khairy Hamdy Ahmed , Safwat Aboraia Ahmed 
Published: October 2019

AbstractA quantitative structure–retention relationship study was performed by thin layer chromatography on a number of β‐blockers using 315 molecular descriptors of which nine were selected to be having the most important physicochemical properties. These descriptors provide good correlations with chromatographic behavior of the studied structurally related drugs. This research was completed on three pretreated silica gel plates via impregnation in urea, sodium dodecyl sulfate, and dimethylformamide, hence it possesses varying interplay mechanisms and polarities. The retention parameters were obtained by utilizing four solvent systems of two additives of variable ratios, consequently specific polarities in addition to imparted different pH values using either glacial acetic acid or liquid ammonia. Calculated theoretical approaches prove good correlations between investigated descriptors and retention factors. Some correlations show excellent predicting models, which might be critical for toning better know‐how relationships between chemical structures and retention of β‐blockers.
Electrochemical corrosion behavior of bronze materials in an acid‐containing simulated atmospheric environment
Authors: Cai Lankun , Chen Mengjie , Wang Ying , Chen Cheng , Zhang Lehua , Zhou Hao , Wu Laiming , Yan Ying 
Published: October 2019

AbstractThe present work investigates the corrosion behavior of bronze materials under thin electrolyte layers (TELs) in a simulated atmospheric environment containing formic and acetic acid by electrochemical measurements as well as surface characterization. The results show that the corrosion of bronze under TEL is significantly faster than that in the bulk solution, and the corrosion rate of bronze is the highest when the thickness of TEL is about 100 μm. Formic acid is observed to be more corrosive than acetic acid. Copper formate and copper acetate hydrate appear in the corrosion products formed on the surface of bronze, suggesting that the organic acid participates in the corrosion process of bronze materials in the simulated atmospheric environment.
The axiom of determinacy implies dependent choice in mice
Authors: Müller Sandra 
Published: October 2019

AbstractWe show that the Axiom of Dependent Choice, , holds in countably iterable, passive premice constructed over their reals which satisfy the Axiom of Determinacy, , in a background universe. This generalizes an argument of Kechris for using Steel's analysis of scales in mice. In particular, we show that for any and any countable set of reals A so that and , we have that .
How different aspects of motor dysfunction influence day‐to‐day function in huntington's disease
Authors: Carlozzi Noelle E. , Schilling Stephen G. , Boileau Nicholas R. , Chou Kelvin L. , Perlmutter Joel S. , Frank Samuel , McCormack Michael K. , Stout Julie C. , Paulsen Jane S. , Lai Jin‐Shei , Dayalu Praveen 
Published: October 2019

AbstractPurposeThis study examined the relationships between different aspects of motor dysfunction (chorea, dystonia, rigidity, incoordination, oculomotor dysfunction, dysarthria, and gait difficulties) and functional status in persons with Huntington's disease.MethodsA total of 527 persons with Huntington's disease completed the Unified Huntington's Disease Rating Scale motor, total functional capacity, and functional assessments.ResultsConfirmatory factor analysis indicated that a 4‐factor model provided a better model fit than the existing 5‐factor model. Exploratory factor analysis identified the following 4 factors from the motor scale: dystonia, chorea, rigidity, and a general motor factor. Regression indicated that dystonia (β = −0.47 and −0.79) and rigidity (β = −0.28 and −0.59) had strong associations with function, whereas chorea had modest correlations (β = −0.16 and −0.15).ConclusionsDystonia and rigidity have stronger relationships with functional status than chorea in persons with Huntington's disease. The findings underscore the need for further research regarding the effects of dystonia and rigidity on functioning. © 2019 International Parkinson and Movement Disorder Society
A synthetic peptide encoded by a random DNA sequence inhibits discrete red light responses
Authors: Shuipys Tautvydas , Carvalho Raquel F. , Clancy Maureen A. , Bao Zhilong , Folta Kevin M. 
Published: October 2019

AbstractWe have identified a synthetic peptide that interrupts discrete aspects of seedling development under red light. Previous reports have demonstrated that plants transformed with random DNA sequences produce synthetic peptides that affect plant biology. In this report, one specific peptide is characterized that inhibits discrete aspects of red light‐mediated photomorphogenic development in Arabidopsis thaliana . Seedlings expressing the PEP6‐32 peptide presented longer hypocotyls and diminished cotyledon expansion when grown under red light. Other red light‐mediated seedling processes such as induction of Lhcb (cab) transcripts or loss of vertical growth remained unaffected. Long‐term responses to red light in PEP6‐32 expressing plants, such as repression of flowering time, did not show defects in red light signaling or integration. A synthesized peptide applied exogenously induced the long‐hypocotyl phenotype under red light in non‐transformed seedlings. The results indicate that the PEP6‐32 peptide causes discrete cell expansion abnormalities during early seedling development in red light that mimic weak phyB alleles, yet only in some aspects of seedling photomorphogenesis. The findings demonstrate that new chemistries derived from random peptide expression can modulate specific facets of plant growth and development.
Goethite Quantum Dots as Multifunctional Additives for Highly Efficient and Stable Perovskite Solar Cells
Authors: Chen Hui , Luo Qiang , Liu Tao , Ren Jing , Li Shuang , Tai Meiqian , Lin Hong , He Hongcai , Wang Jinshu , Wang Ning 
Published: October 2019

AbstractMinimization of defects and ion migration in organic–inorganic lead halide perovskite films is desirable for obtaining photovoltaic devices with high power conversion efficiency (PCE) and long‐term stability. However, achieving this target is still a challenge due to the lack of efficient multifunctional passivators. Herein, to address this issue, n‐type goethite (FeOOH) quantum dots (QDs) are introduced into the perovskite light‐absorption layer for achieving efficient and stable perovskite solar cells (PSCs). It is found that the iron, oxygen, and hydroxyl of FeOOH QDs can interact with iodine, lead, and methylamine, respectively. As a result, the crystallization kinetics process can be retarded, thereby resulting in high quality perovskite films with large grain size. Meanwhile, the trap states of perovskite can be effectively passivated via interaction with the under‐coordinated metal (Pb) cations, halide (I) anions on the perovskite crystal surface. Consequently, the PSCs with FeOOH QDs achieve a high efficiency close to 20% with negligible hysteresis. Most strikingly, the long‐term stability of PSCs is significantly enhanced. Furthermore, compared with the CH3NH3PbI3‐based device, a higher PCE of 21.0% is achieved for the device assembled with a Cs0.05FA0.81MA0.14PbBr0.45I2.55 perovskite layer.
Cognitive training increases dendritic arborization in the dorsal hippocampal CA1 and CA3 neurons of female and male Long–Evans rats
Authors: Villanueva Espino Luis Alberto , Silva Gómez Adriana Berenice , Bravo Durán Dolores Adriana 
Published: October 2019

AbstractExperiences influence the development of the central nervous system. Cognitive training promotes changes in the structure of the brain, such as in its weight and number of cells, as well as ability to perform dendritic remodeling. The present study was designed to detect possible differences in the neuronal morphology of the dorsal hippocampus between female and male Long–Evans rats after cognitive training (CT). CT was promoted through three learning and memory tests: the Morris water maze, the Barnes circular maze, and Novel object recognition tests. Our data revealed no differences in learning or memory capacities between female and male rats; rats of the two sexes solved the behavioral test with equal efficiency. CT caused an increase in the basilar and apical dendritic arborization of CA1 neurons in male rats, whereas female rats that underwent CT presented only remodeling in the apical arbors of CA1 neurons. The basilar arbors of CA3 neurons of female rats showed an increase in arborization, but their apical arbors were not modified; the arbors of CA3 neurons of male rats submitted to CT were not modified. Total dendritic length was modified by CT in the apical arbors of CA1 neurons of female and male rats and in the basilar CA1 arbors of male rats. There was a significant increase in dendritic spine density in all arbors of CA1 and CA3 neurons of females and males subjected to CT. These results suggest that dendritic remodeling after CT is similar between female and male rats.