bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inetetamab for injection in combination with vinorelbine weekly or every three weeks in HER2-positive metastatic breast cancer: A multicenter, randomized, phase II clinical trial
Authors: Shao Xiying , Xie Ning , Chen Zhanhong , Wang Xinshuai , Cao Wenming , Zheng Yabing , Yang Hua , Huang Jian , Chen Shaoping , Gan Lu , Yang Xiuli , Chen Yuru , Ouyang Quchang , Wang Xiaojia 
Published: November 2024

Abstract

Objective
We aimed to investigate the pharmacokinetics, safety, efficacy, and immunogenicity of different dosing regimens (weekly and every three weeks) of inetetamab in combination with vinorelbine in human epidermal growth factor receptor 2 (HER2)+ patients with metastatic breast cancer who had received one or more chemotherapy regimens.

Methods
HER2+ patients with metastatic breast cancer who had received one or more chemotherapy regimens were included. Eligible patients received inetetamab administered weekly or every three weeks in combination with vinorelbine injection chemotherapy. Pharmacokinetics, safety, efficacy, and immunogenicity were compared between the groups.

Results
Sixty HER2+ patients were randomized into a single-week administration group ( n = 29) and a three-week administration group ( n = 31). After the final dose in the single-week administration group and the three-week administration group, the mean Cmax values were 79.773 μg/mL and 146.083 μg/mL; the mean Cmin values were 30.227 μg/mL and 11.926 μg/mL; the mean AUCtau values were 7328.443 μg·h/mL and 22647.101 μg·h/mL; and the mean Cav values were 43.622 μg/ mL and 44.935 μg/mL, respectively. The best overall response (BOR) rates at 24 weeks and unconfirmed BOR rates at 24 weeks were both 40.7% in the single-week dosing group and 40.7% in the three-week dosing group, and the 24-week confirmed disease control rates (DCRs) were 88.9% and 81.5%, respectively. The incidence of adverse events (AEs) was generally consistent across all levels.

Conclusion
There were slight differences in the mean Cmax, Cmin, AUCtau and Cav between the three-week dosing group and the single-week dosing group, and the mean steady-state concentrations of Cav were comparable; however, there were no differences in efficacy, safety or immunogenicity between the two groups.
Technical efficiency of sugarcane farming in East Java, Indonesia: A bootstrap data envelopment analysis
Authors: Santosa Agus , Rahayu Endang Siti , Sutrisno Joko , Kusnandar Kusnandar 
Published: November 2024

Abstract
Sugarcane is an essential commodity in Indonesia. However, climate change negatively affects the sugarcane production efficiency. This study aims to measure the technical efficiency of sugarcane farming using a bootstrap data envelopment analysis (DEA) approach, compare the efficiency of irrigated and rain-fed sugarcane farming, and determine the factors affecting the technical efficiency of sugarcane farming in East Java, Indonesia. Primary data were collected from 451 sugarcane farmers during the 2020–2021 planting season. The results indicate that the “bias-corrected” technical efficiency scores of the single- and double-bootstrap approach (0.624 and 0.561) were lower than that of conventional DEA (0.714). The efficiency score of irrigated sugarcane farms (0.593) was higher than that of rain-fed farms (0.529). Moreover, the farmers’ age, household size, dependency, farming experience, training, subsidies, crop diversification, and access to irrigation impacted sugarcane farming’s technical efficiency. Improvement of 1% in training, irrigation access, and subsidies increased the technical efficiency by 0.034, 0.032, and 0.030, respectively. This strategy is expected to enhance the productivity and technical efficiency and reduce the poverty in rural households in East Java.
Review on geopolymer concrete incorporating Alccofine-1203
Authors: Chaudhary Shashank , Dubey Sheo Kumer , Sharma Abhay 
Published: November 2024

Abstract
The emergence of geopolymer concrete (GPC) has occurred as a sustainable substitute for conventional cement-based concrete, offering enhanced mechanical characteristics and reduced environmental impact. In the quest to further optimize GPC, incorporating supplementary cementitious materials has gained attention. For the research, Alccofine-1203 was considered as the material for incorporation into the geo-polymer concrete. This review study specifically examines the utilization of Alccofine-1203 as a material in GPC within the domain of structural engineering. Alccofine-1203, a high-performance mineral additive, exhibits pozzolanic and reactive properties, making it a promising candidate for enhancing GPC performance. This paper provides a comprehensive analysis of the chemical compositions and physical properties of Alccofine 1203, highlighting its potential benefits in GPC. Furthermore, it explores the influence of Alccofine-1203 on various aspects of GPC, including workability, compressive strength, flexural strength, durability, microstructure, and thermal properties. The review encompasses an analysis of relevant tests conducted to evaluate these properties. In summary, this review article is a great resource for researchers, engineers, and practitioners who are interested in the development and application of GPC containing Alccofine-1203.
Zygmunt Łempicki im Kontext der deutschen Literaturwissenschaft der Zwischenkriegszeit
Authors: Müller Hans-Harald 
Published: November 2024

Abstract
This essay rescues from oblivion the now almost forgotten work of the Polish philologist and publicist Zygmunt Łempicki, who was, due to his renowned German-language publications, a well-known figure in German literary studies in the period between the two World Wars. Of particular interest is Łempicki’s theoretical position in German literary studies at the time, which is examined here. Based on his education in Twardowski’s logical school of Lviv, Łempicki developed an analytical, conceptually and historically honed mode of reflection for literary studies concepts, which allowed him to develop a meta-theoretical critique, the main features of which are still relevant today.
»Meine furchtbaren Träume / habe ich erlebt!«
Authors: Conterno Chiara 
Published: November 2024

Abstract
This article focuses on Paula Ludwig’s dream texts (›Traumtexte‹) and her dream conception. Fundamental to understand her concept of dreams is her stay in Munich, where she encountered numerous intellectuals and lovers of culture, including Grete Weisberger and Karl Wolfskehl. It is likely in this context that she came into contact with Ludwig Klages’ dream theories, which have left clear traces in the paratexts of her dream collections. However the development of National Socialism and the outbreak of the Second World War soon disrupted European and world history, which was reflected in Paula Ludwig’s life and work. Accordingly, the article aims to shed light on the incursion of history into Paula Ludwig’s dream world, using a philological and hermeneutic method that also considers biographical, historical and cultural aspects.
»Yes, I am a Catholic, the worst kind – a convert«
Authors: Höffler Ricarda 
Published: November 2024

Abstract
The article examines the significance of the Incarnation of Christ for the development of Marshall McLuhan’s media theory. McLuhan’s Catholicism was already a topic of debate in the 1960s and 70s, albeit often in a less than benevolent manner. More recently, however, scholars from the English-speaking world have approached McLuhan’s religious convictions and their possible influence on his media-theoretical considerations in a more nuanced way. Building on this research, the article argues that McLuhan’s understanding of media and their effects, summarized in the famous phrase »The medium is the message«, can hardly be separated from his belief in the Incarnation, which has often been neglected by German scholars. If one takes a closer look at a variety of sources, e. g. letters and essays written from the 1930s onwards, it becomes clear that McLuhan considered human creativity to be the result of the total remaking of human nature by the ›medium of all media‹, i. e. God incarnate, and that it is precisely these christological and anthropological principles that underlie his media theory.
Assessment of attitude and knowledge of infection control practices amongst UG dental students in Uttarakhand towards immunocompromised patients undergoing treatment - A questionnaire based study
Authors: Agnihotri Vedika , Kandari Yaghya , Gangwar Vinay , Grover Sheetal , Nautiyal Unnati , Dhingra Anil 
Published: November 2024

This study aimed to assess the attitude and knowledge of infection control practices amongst undergraduate (UG) dental students in Uttarakhand towards immunocompromised patients undergoing dental treatment. The objective was to evaluate the level of awareness and adherence to infection control protocols among UG dental students in Uttarakhand and to identify any gaps in knowledge or attitude towards treating immunocompromised patients. A questionnaire-based survey was conducted, comprising questions related to infection control practices and attitudes towards treating immunocompromised patients. The survey was distributed to 300 UG dental students across multiple dental colleges in Uttarakhand. Data collected were analyzed using statistical methods to identify trends and assess knowledge levels. The results revealed varying levels of awareness and adherence to infection control practices among UG dental students. While a majority demonstrated adequate knowledge, there were notable gaps in understanding specific protocols related to treating immunocompromised patients. Additionally, attitudes towards such patients varied, with some students expressing hesitation or uncertainty in providing treatment. This study underscores the importance of ongoing education and training in infection control practices among dental students, particularly concerning the treatment of immunocompromised patients. Addressing knowledge gaps and fostering a positive attitude towards providing care for this vulnerable population is essential to ensure optimal patient outcomes and minimize the risk of infection transmission.
“Don’t just be ordinary”: Understanding the Resilience of College Students of Color at a Predominantly White Institution
Authors: Storlie Cassandra Ann , Mulvey Bridget , Erby Adrienne 
Published: November 2024

Despite the prevalence of student multicultural centers providing support to students of Color across higher education institutions in the United States, experiences related to marginalization and discrimination remain present on college campuses. Using an ecological systems framework, researchers interviewed seven undergraduates active with their university’s student multicultural center to explore their experiences of resilience more deeply at a Predominantly White Institution (PWI). Findings indicate a need for expanding support for students who experience frequent microaggressions and stereotyping related to their marginalized identities. Systemic recommendations for working with college students of Color are presented.
Iron Seller Activities in Riverbank Communities in South Kuin Village
Authors: Radjikan Febrian Putra Anugrah , Syaharuddin Syaharuddin , Handy Muhammad Rezky Noor , Nur’aini Fatwa , Rusmaniah Rusmaniah 
Published: November 2024

The background of the iron sellers in the riverbank is a human unit or group of people living in along the riverbank. Their lives are dominated by river culture. However, the life of the Bantaran Sungai community in Kuin Selatan Village, Banjarmasin, gives a different and very interesting nuance. There are forms of economic activity in the area that indirectly do not influent in the river for the spring of life, but present a complete form of economic activity, both from production and distribution and consumption activities. This is reflected in the economic activity of iron craftsmen. The points at this research were: (1.) To discover out what kinds of goods were made by iron sellers in Kuin Selatan Village, (2.) To find out the making, marketing and usage activities take out by iron sellers at Kuin Selatan Village, (3.) To discover out the ways of making iron by iron sellers. Descriptive qualitative method was used in the research to illustrate the economic activities of the riverbank groups in Kuin Selatan Village. The person in this research were iron craftsmen. The research instrument consisted of observation guides and interviews made by the researchers themselves. The data analysis technique used is data reduction, data presentation and conclusion. Test the validity of the data using time triangulation, sources and data collection techniques.The conclusions appear that the interesting economic activity of the riverbank groups in Kuin Selatan Town was ironmonger. Its economic activities contain: (1.) production activities, (2.) marketing activities, (3.) usage activities. The making activities of the iron craftsmen are in the form of agricultural tools such as hoes, crowbars, machetes, sickles, and also in the form of household utensils such as frying pans, knives and panicles. In addition, other products include bolts, drills, truck elbows, hinges, valves, drums and containers. Distribution activities can be seen in the acquisition of raw materials and distribution of production results to consumers. The form of distribution of goods is carried out directly or indirectly. Obtaining nail materials indirectly through collectors, while the distribution of manufactured goods through agents. The consumption activities of iron craftsmen are carried out directly, namely buyers come directly to the craftsmen to buy the goods they produce and indirectly, namely traders buy to be resold to the market to consumers. The conclusion reached by these iron sellers is that we can get to know the processing of iron goods which can be made into several kinds of tools to break down gold such as drums and valves for example, accompanied by activation of production, distribution and consumption
Immunohistochemical Diagnostic value of Calretinin in Hirschprung Disease
Authors: Azis Zainab , Cangara M. Husni , Zainuddin Andi Alfian , Wahid Syarifuddin , Mariana Nita , Miskad Upik A. 
Published: November 2024

Introduction: Hirschsprung's disease (HD) is characterized by the absence of ganglion cells in Meissner's plexus and Auerbach's plexus which used to be assessed by histopathological examination using Hematoxylin and Eosin (H&E). In some cases is difficult to assess ganglion cells, thus requiring additional examination in the form of calretinin immunohistochemistry to detect the presence of ganglion. Methods: The 59 samples of suspected HD were analyzed by H&E staining followed by calretinin immunohistochemical staining. This study aimed to assess the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of calretinin in HD diagnostics. Results: The immunohistochemistry of calretinin showed a good diagnostic value in detecting aganglionosis in patients with suspected HD with a sensitivity value = 97.7%; Specificity = 100%; Positive Presumptive Value (PPV) = 100%; Negative Presumptive Value (NPV) = 93.7%; Accuracy= 98.3%. Thus, calretinin immunohistochemistry can be relied upon as an additional method in the diagnosis of HD
The Dermatofibrosarcoma Protuberans In A 13-Year-Old: A Rare Case Of Soft Tissue Sarcoma Of The Skin
Authors: . Windy Rhomadani Putra , Iskandar Fery , Dumaria Ketty  
Published: November 2024

Introduction and importance: Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma that primarily affects middle-aged adults but can also occur in children. Despite its low metastatic potential, DFSP displays aggressive local behavior and a high rate of local recurrence. Diagnosis in children can be delayed due to confusion with other skin conditions. This case report aims to discuss the case management of dermatofibrosarcoma protuberans in a 13 year old female. Presentation of case: A 13-year-old female patient presented with a progressively enlarging lump on the left eyelid, initially resembling small brown spots that coalesced over 7 months. Intermittent bleeding and pain were reported. Physical examination revealed a dark brown mass in the left frontotemporal region, with solid, non-fragile characteristics. Clinical diagnosis suggested a suspicious malignant skin tumor, confirmed as basal cell carcinoma. Treatment involved wide excision and flap reconstruction. Post-operative care included infusion, antibiotic injection, and pain management. The patient's prognosis was favorable, though functional impairment was possible. Follow-up revealed histopathological findings of pigmented dermatofibrosarcoma protuberans. Discussion: DFSP is a rare but significant malignancy that poses diagnostic challenges due to its varied clinical presentations and histopathological features. While primarily affecting young to middle-aged individuals, it can also manifest in pediatric populations. Diagnosis typically involves histopathological assessment, confirming characteristic spindle cell proliferation with CD34 expression. Surgical excision remains the cornerstone of treatment, complemented by adjuvant therapies like imatinib mesylate or radiation in select cases. Regular surveillance, comprising frequent evaluations in the initial post-excision period followed by yearly monitoring, is imperative for detecting any recurrence or metastasis promptly. Conclusions: The structured approach in DFSP ensures optimal patient management and outcomes. Surgical management with Wide local excision (WLE) or Mohs micrographic surgery (MMS) is the gold standard in the treatment of DFSP.
Üniversite Öğrencilerinde Temporomandibular Eklem Disfonksiyonu Prevalansının Araştırılması
Authors: Kaynak Besime Ahu , Taş Serkan , Ünlüer Nezehat Özgül , Yaşar Ümit , Erdoğanoğlu Yıldız 
Published: November 2024

Amaç: Bu çalışmanın
amacı, üniversite öğrencilerinde
temporomandibular eklem disfonksiyonu (TMED) prevalansının araştırılmasıdır. Gereç ve Yöntem: Bu çalışma, 18-25 yaş
aralığında (20,5±1,5 yıl) 1104 kadın ve 334 erkek olmak üzere 1438 üniversite
öğrencisinin katılımıyla gerçekleşti. Çalışmaya katılan bireylerde TMED varlığı,
Fonseca Anamnestik Anketi kullanılarak değerlendirildi. Fonseca Anamnestik
Anketi 10 sorudan oluşmaktadır. Katılımcıdan her soruya ‘Evet’ (10 puan),
‘Hayır’ (0 puan) ve ‘Bazen’ (5 puan) olmak üzere cevap vermesi istenir. Anket
sonucunda elde edilen skora göre bireyler TMED yok (0-15 puan), hafif TMED’li
(20-40 puan), orta şiddette TMED’li (45-65 puan) ve şiddetli TMED’li (70-100)
olarak sınıflandırıldı. Bulgular: Değerlendirilen
1438 bireyden 547’sinde (%38) TMED olmadığı bulunurken, bireylerin 891’inde
(%62) TMED olduğu tespit edildi. TMED’li bireylerde TMED şiddeti
incelendiğinde, TMED tespit edilen 891 bireyden 664’ünde (%46,2) hafif şiddette
TMED, 180’ında orta şiddette TMED (%12,5) ve 47’sinde (%3,3) şiddetli TMED
olduğu bulundu. Değerlendirilen 1104 kadın bireyden 730’unda (%66,1) TMED
tespit edilirken, 374 kadın bireyde (%33,9) TMED olmadığı bulundu.
Değerlendirilen 334 erkek bireyden 173’ünde (%51,3) TMED yok iken, 161 erkek
bireyde (%48,7) TMED olduğu bulundu.

Sonuç: Elde edilen sonuçlar üniversite öğrencilerinde TMED
prevalasının %62 olduğunu göstermektedir. Ayrıca, TMED’li bireylerin önemli bir
kısmının hafif TMED’li bireylerden oluştuğu tespit edildi. Kadınlarda TMED
prevalansının ve şiddetinin erkeklere göre daha fazla olduğu bulundu.
Erken Yıllarda İki Dilde Eğitim: Öğretmenlerin Bakış Açısıyla Etki ve Sonuçların İncelenmesi
Authors: Tercan Hülya , Tercan Ceren 
Published: November 2024

Amaç İki dilde eğitim, yaklaşık 50 yılı aşkın bir süredir birçok ülkede eğitimsel bir seçenek olarak uygulanmaktadır. Literatür incelendiğinde alanda yapılan çalışmaların genellikle derleme özellikte oldukları dikkat çekmektedir. Son yıllarda ülkemizde de giderek yaygınlaşan iki dilde okul öncesi eğitim ile ilgili planlanan bu çalışmanın amacı, erken yıllarda iki dilde eğitim alan 2-6 yaş aralığındaki çocukların iki dilli sürece adaptasyonu, geçirdikleri aşamalar ve verilen tepkilerin öğretmenlerinin gözünden incelenmesidir. Gereç ve Yöntem: Araştırmada uygun veriler elde edilebilmek için araştırma tekniklerinden nitel teknik kullanılıştır. Bu kapsamda Ankara ilinde iki dilde eğitim veren bir okul öncesi eğitim kurumundaki okul öncesi öğretmenleri ve İngilizce öğretmenleri ile yarı yapılandırılmış bireysel görüşmeler yapılmıştır. Verilerin analizinde betimsel analiz tekniği kullanılmıştır. Bulgular - Sonuç: Bu araştırmanın sonucunda, öğretmenlerin cevaplarından elde edilen bulgular çocukların genel gelişimsel özellikleri ve iki dilli eğitim sürecine etkisi, iki dilli eğitime uyum süreci, iki dilli eğitimin çocuklara etkileri, iki dilli eğitim sürecinde aile tepkileri, iki dilli eğitim ile ilgili öneriler ana temaları ile ilişkilendirilmiş, bulgular direk alıntılar şeklinde sunulmuştur. Bu çalışmanın sonuçlarının, bu alanda çalışan uzmanlara, ailelere ve iki dilde eğitim alan çocuklara olumlu çıktıları olacağı düşünülmektedir.
Localization of mesenchymal stem cells populations in the adult human dental pulp
Authors: Alzer Heba , Alsoleihat Firas , Al-Shayyab Mohammed , Shahin Nisreen Abu , Kalbouneh Heba 
Published: November 2024

Abstract

Background: Despite comprehensive studies and reports about the properties of dental pulp stem cells (DPSCs) in vitro, we still lack the knowledge of whether these in vitro characteristics coincide with the original nature of DPSCs in situ. The histological location of DPSCs populations in the dental pulp has been rarely investigated.
Methods: In this study, well-recognized mesenchymal stem cell markers MCAM, CD73, STRO1, Thy1, and CD105 are being investigated by immunohistochemistry to localize the precise location of these populations of DPSCs within the human adult dental pulp.
Results. All previously mentioned markers were expressed in the dental pulp, and their intensity and location of expression were reported.
Conclusion: The observations that multiple mesenchymal stem cell niches exist may have further implications for their recruitment in situ for multiple regenerative therapies.
Food-washing monkeys recognize the law of diminishing returns
Authors: Dominy Nathaniel , Rosien Jessica , Fannin Luke , Yeakel Justin , Malaivijitnond Suchinda , Tan Amanda 
Published: November 2024

Abstract

Few animals have the cognitive faculties or prehensile abilities needed to eliminate tooth-damaging grit from food surfaces. Some populations of monkeys wash sand from foods when standing water is readily accessible, but this propensity varies within groups for reasons unknown. Spontaneous food-washing emerged recently in a group of long-tailed macaques (Macaca fascicularis) inhabiting Koram Island, Thailand, and it motivated us to explore the factors that drive individual variability. We measured the mineral and physical properties of contaminant sands and conducted a field experiment, eliciting 1,282 food-handling bouts by 42 monkeys. Our results verify two long-standing presumptions, that monkeys have a strong aversion to sand and that removing it is intentional. Reinforcing this result, we found that monkeys clean foods beyond the point of diminishing returns, a suboptimal behavior that varied with social rank. Dominant monkeys abstained from washing, a choice consistent with the impulses of dominant monkeys elsewhere: to prioritize rapid food intake and greater reproductive fitness over the long-term benefits of prolonging tooth function