bluuebunny/crossref_metadata_2025_split huggingface dataset:
Some remarks on the nature of mantle metasomatism beneath western Anatolian–Aegean region: Contrasting isotopic signatures recorded in the Miocene lavas from the Söke Basin
Authors: Aldanmaz Ercan , Altunkaynak Şafak , Güçtekin Aykut 
Published: November 2018

The presence of a subduction signature with variable isotopic patterns in the melt products of mantle origin within the Aegean–Anatolian domain reflects the differential effects of slab‐derived material on the chemical composition of the supraslab mantle region. Here, we use Sr–Nd–Pb isotopic compositions and major and trace element abundances to evaluate the characteristics of the source components and possible roles of fluid/melt metasomatism in the genesis of the Middle to Late Miocene mafic–intermediate lavas from the Söke Basin in western Anatolia. This volcanic suite comprises a number of individual lava flows in which the dominant rock types are potassium‐rich basaltic andesites and andesites with trace element relative abundances indicative of melt derivation from subduction‐modified sources. These samples have significantly heterogeneous Sr and Nd isotopic ratios, with 87Sr/86Sr and 143Nd/144Nd values ranging from 0.70475 to 0.70927 and from 0.51218 to 0.51270, respectively; they also yield a range of Pb isotope ratios, with 206Pb/204Pb = 18.963–19.344, 207Pb/204Pb = 15.672–15.733, and 208Pb/204Pb = 39.096–39.264. Remarkably large variations in isotopic ratios with relatively limited changes in major elements suggest the involvement of heterogeneously enriched sources with diverse isotopic signatures. The modelling of trace element and isotopic data indicates that parts of the lithospheric mantle in this region are isotopically enriched, with geochemical signatures that reflect the interaction of variably depleted mantle peridotites with melts from subducted sediments of continental crustal origin, while other parts host phlogopite‐rich metasomatic components with signatures of devolatilization reactions from ancient subduction events that led to the preferential loss of Pb and Rb to create metasomatic domains with high U/Pb and low Rb/Sr values that ultimately generated highly radiogenic 206Pb/204Pb and relatively unradiogenic 87Sr/86Sr values. The observed isotopic diversity in relatively short‐time‐ and length‐scales may be interpreted to have resulted largely from the variable extent of melt contributions from a number of discrete lithological domains with contrasting long‐term isotopic evolution and is consistent with the view that the continental lithosphere in this region comprises a number of disparate lithospheric fragments with different petrogenetic histories.
Footprints of an elusive mid‐14th century earthquake in the central Himalaya: Consilience of evidence from Nepal and India
Authors: Rajendran C. P. , Sanwal Jaishri , John Biju , Anandasabari K. , Rajendran Kusala , Kumar Pankaj , Jaiswal Manoj , Chopra Sundeep 
Published: November 2018

The timing and size of the last great earthquake in the central Himalaya continues to excite scientific controversy, despite a decade of palaeoseismological investigations. The studies along the frontal thrust in the Indian part of the central Himalaya disclose a faulting event between 14th and 15th century, and a dominant view presupposes the 1505 CE earthquake as the likely source. Here we evaluate the database along with independent inputs to determine the timing of the last faulting event on the frontal thrust of the central Himalaya. From the historical perspective, the Nepalese archives make a direct reference to a significant earthquake in 1344 CE, and the Indian sources hint at a restoration phase for the mid‐14th century monuments in the northern plains and coeval destruction to the ancient temples in the central Himalaya. Aside from the constraints generated from the earthquake proxies including liquefaction features and deformed stalagmites, the previous and currently acquired geological data from multiple trenches across the frontal thrust show that the last faulting event occurred between 13th and 14th centuries—the time interval coinciding with the 1344 CE earthquake. The episodic valley fills debris flow depositions identified in the Pokhara Valley in the east‐central Nepal provide additional constraints for the 1344 CE earthquake along with two previous ones in 1255 and 1100 CE. The consilience of multiple pieces of evidence from India and Nepal in combination with the new data inputs from two trench locales implicates the 1344 CE as the last of the medieval sequence of earthquakes. With a rupture length of ~600 km of the central Indian Himalaya and an average slip of 15 m, this earthquake is consistent with moment magnitude of Mw≥8.5. An earthquake of similar size is overdue in this part of the Himalaya, considering the long elapsed time of ≤700 years.
Increased mortality and hospital readmission risk in patients with dementia and a history of cardiovascular disease: Results from a nationwide registry linkage study
Authors: van de Vorst Irene E. , Vaartjes Ilonca , Bots Michiel L. , Koek Huiberdina L. 
Published: November 2018

ObjectiveTo evaluate the impact of cardiovascular disease (CVD) on mortality and readmission risk in patients with dementia.MethodsProspective hospital‐based cohort of 59 194 patients with dementia admitted to hospital or visiting a day‐clinic between 2000 and 2010. Patients were divided in those with and without a history of CVD (ie, previous admission for CVD; coronary heart disease, heart failure, stroke, atrial fibrillation, or other CVD). Absolute mortality risks (ARs), median survival times, and hazard ratios (adjusted for age, sex, and comorbidity) were calculated.ResultsThree‐year ARs and HRs were higher, and survival times were shorter among patients visiting a day‐clinic with a history of CVD than in those without. The differences were less pronounced for inpatients. Readmission risk was further increased in the presence of CVD in both day clinic and inpatients.ConclusionClinicians need to be more aware of worse prognosis of the population with CVD and dementia.
Identifying the timing and duration of collecting patient priorities in an orthopedic clinic
Authors: Jurewicz Katherina A. , Hobbs Mary A. , Neyens David M. , Childers Ashley K. , Cozad Melanie J. , Brooks John M. 
Published: November 2018

AbstractThe patient‐centered care model supports patients actively engaging in their care. Typically this involves collecting patient‐reported outcomes and priorities that may not be part of the routine practice. There is a research gap related to whether there is time available within the routine orthopedic medical practice to collect patient‐centered data for immediate use without delaying the overall clinical processes or influencing patient clinical experiences. A time study was conducted to quantify the current patient processes at an orthopedic clinic, and a statistical simulation model was used to evaluate potential changes in patients’ clinical process if a patient‐centered survey were to be implemented. The proportion of simulated patients who would experience delays due to the survey, the durations of their delays, and the average duration of the patient process delay were recorded at each step in the clinical process. The results are presented in terms of the relationship between the time devoted to collecting data and the impact on the patient experience for various survey durations at various process points. This study demonstrates an approach to evaluate how introducing a patient priorities survey (for collecting both patient‐reported outcomes and priorities), which could be used in the same patient visit, might impact the clinical process and introduce process delays.
The effects of different periods of co‐administration of oral and long‐acting injectable aripiprazole: A propensity score analysis
Authors: Hatano Masakazu , Kamei Hiroyuki , Takeuchi Ippei , Tozawa Kaori , Makino Shinya , Hanya Manako , Yamada Shigeki , Iwata Nakao 
Published: November 2018

AbstractObjectiveLong‐acting injectable (LAI) aripiprazole is recommended to be combined with oral aripiprazole for 2 weeks after its introduction. However, we often experience patients who require more than 2 weeks of combined use. Therefore, differences in combination periods need to be examined.MethodsThis was a case–control study. We surveyed prescription profiles for oral aripiprazole administration in conjunction with LAI aripiprazole introduction and assessed the clinical course during a 12‐week follow‐up period.ResultsAmong 121 patients, 58 (47.9%) were administered both oral and LAI aripiprazole for more than 2 weeks. Although there was no significant difference in treatment failure (defined as psychiatric hospitalization or discontinuation of LAI aripiprazole from any cause) between the two groups, the group that was administered oral aripiprazole for more than 2 weeks received less additional benzodiazepines compared with that of the 2 weeks group (adjusted odds ratio, 0.055; 95% confidence interval [0.0060, 0.50]; p < 0.01).ConclusionsOur data support a flexible co‐administration period for oral and LAI aripiprazole in consideration of the pharmacokinetics, but further studies are needed.
Opening Advanced Laboratories to School Students: Our Model for Structuring Round‐Trip Activities from School to University and Back
Authors: Goldstein Keith L. , Seri Noa , Viale Giovanna , Grazioli Cinzia , Pirovano Livia , Ofrath Noa 
Published: November 2018

AbstractCollaboration with universities may assist secondary schools faced with challenges of promoting state‐of‐the‐art chemistry and biosciences education. This paper outlines university‐based programs in Israel (Belmonte) and Italy (CusMiBio) that enhance learning experiences by allowing classes of pupils to interact with academics and perform hands‐on experiments in advanced scientific laboratories. These programs facilitate a symbiotic relationship between secondary schools and the university. This paper outlines a conceptual model for university‐based science interventions. We describe the programs at Belmonte and CusMiBio, and explain how each program implements group activities for hybrid science laboratories that aim to enhance learning. Teacher training is also described, along with activities essential for establishing a round‐trip experience‐ whereby learning activities continue to have an impact after completion of these special trips to the university laboratory.
Metal‐Organic Cages for Biomedical Applications
Authors: Zhu Cheng‐Yi , Pan Mei , Su Cheng‐Yong 
Published: November 2018

AbstractMetal‐organic cages (MOCs) have uniquely discrete structures, inner cavities and non‐covalent encapsulating capabilities for guests. Recently, MOCs have emerged as potential candidates with multimode biomedical functions. In this review, the application of MOCs in biomedical fields is surveyed from four aspects: anticancer activities, drug carriers, sensing agents, and photodynamic therapy (PDT).
Glucagon attenuates lipid accumulation in cow hepatocytes through AMPK signaling pathway activation
Authors: Li Yu , Ding Hongyan , Dong Jihong , Ur Rahman Sajid , Feng Shibin , Wang Xichun , Wu Jinjie , Wang Zhe , Liu Guowen , Li Xiaobing , Li Xinwei 
Published: November 2018

AbstractThe ketotic cows displayed hepatic lipid metabolic disorder and high blood concentration of glucagon. Importantly, adenosine monophosphate‐activated protein kinase (AMPK) signaling pathway plays an important role in the hepatic lipid homeostasis. Therefore, the aim of this study was to investigate the effect of glucagon on AMPK pathway and its underlying mechanism on lipid metabolism in cow hepatocytes. Cow hepatocytes were cultured and treated with glucagon and AMPK inhibitor (BML‐275). The results showed that glucagon significantly promoted the expression of glucagon receptor and increased the phosphorylation level and activity of AMPKα. Activated AMPKα increased the expression level and transcriptional activity of peroxisome proliferator‐activated receptor α, which further increased the expression of fatty acid oxidation genes and lipid oxidation. Furthermore, activated AMPKα inhibited the expression level and transcriptional activity of sterol regulatory element binding protein‐1c and carbohydrate response element binding protein, which decreased the expression of lipogenic genes, thereby decreasing lipid synthesis. In addition, glucagon also increased the expression of very‐low‐density lipoprotein (VLDL) assembly to export intracellular triglycerides (TG). Consequently, the content of intracellular TG was significantly decreased in cow hepatocytes. These results indicate that glucagon activates the AMPK signaling pathway to increase lipid oxidation and VLDL assembly and decrease lipid synthesis in cow hepatocytes, thereby reducing liver fat accumulation.
Altered plasma proteins released from platelets and endothelial cells are associated with human patent ductus arteriosus
Authors: Hou Hai‐Tao , Xi‐Zhang  , Wang Jun , Liu Li‐Xin , Zhang Jian‐Feng , Yang Qin , He Guo‐Wei 
Published: November 2018

AbstractPatent ductus arteriosus is the third most common congenital heart disease and resulted from the persistence of ductal patency after birth. Ductus arteriosus closure involves functional and structural remodeling, controlled by many factors. The changes in plasma protein levels associated with PDA closure are not known. Here we for the first time demonstrate six key differential plasma proteins in human patent ductus arteriosus patients using proteomic technology and present a model to illustrate the constriction and closure of ductus arteriosus. Differentially expressed proteins were analyzed by using isobaric tags for relative and absolute quantification and validated by enzyme‐linked immunosorbent assay in new samples. The proteomic data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the data set identifier PXD008568. We found 74 upregulated and 98 downregulated proteins in the plasma of patients with PDA. Five decreased proteins (platelet factor 4, fibrinogen, von Willebrand factor, collagen, and mannose binding lectin‐associated serine protease‐2) and one increased protein (fibronectin) may increase the risk of patent ductus arteriosus. Those proteins are closely related to platelet activation and coagulation cascades, complement mannan‐binding‐lectin, and other systemic signaling pathways. Our findings for the first time indicate that the differential proteins involved in different pathways may play key roles in the nonclosure of the ductus arteriosus in humans and may be developed as biomarkers for diagnosis. All those findings may be served as the basis of understanding the etiology and pathogenesis of patent ductus arteriosus.
miR‐142‐3p as tumor suppressor miRNA in the regulation of tumorigenicity, invasion and migration of human breast cancer by targeting Bach‐1 expression
Authors: Mansoori Behzad , Mohammadi Ali , Ghasabi Mehri , Shirjang Solmaz , Dehghan Razeieh , Montazeri Vahid , Holmskov Uffe , Kazemi Tohid , Duijf Pascal , Gjerstorff Morten , Baradaran Behzad 
Published: November 2018

AbstractBackgroundBreast cancer is the most common type of cancer among women, and despite improved treatments, it remains a major challenge. However, improved mechanistic insight may lead to novel therapeutic strategies. miR‐142‐3p belongs to the miR‐142 family and is involved in pathogenesis and metastasis of various types of malignancies by targeting several important messenger RNAs (mRNAs) including Bach‐1. This is especially true for breast cancer, where Bach‐1 is involved in the metastatic spread by deregulation of metastasis‐associated genes.MethodsIn this study, we collected 24 breast cancer tissues with 24 adjusted normal tissues to measure the expression levels of miR‐142‐3p and Bach‐1 mRNA using quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR) and IHC. miR‐142‐3p targeting of Bach‐1 expression in MCF‐7 and MDA‐MB‐468 breast cancer cells was evaluated using bioinformatics, qRT‐PCR and western blot analyses. The cellular proliferation, invasion, and migration were assessed by MTT, transwell matrigel and wound healing assay and the EMT‐associated proteins C‐X‐C chemokine receptor type 4 (CXCR‐4), matrix metalloproteinase‐9 (MMP9), and vascular endothelial growth factor receptor (VEGFR) were analyzed by western blot analysis. Also, the expression levels of tumor suppressors including miR‐330, miR‐145, and miR‐34a were estimated by qRT‐PCR.ResultsAnalysis of paired specimens of primary malignant and normal tissues showed that miR‐142‐3p was downregulated, while Bach‐1 mRNA and protein both were overexpressed in the breast cancer tumors. This inverse relationship was confirmed by cell line experiments demonstrating that miR‐142‐3p expression reduced Bach‐1 mRNA levels. Furthermore, replacement of miR‐142‐3p could inhibit the proliferation, invasion, and migration in breast cancer potentially by targeting of Bach‐1 mRNA and subsequent inhibition of CXCR4, MMP9, and VEGFR protein expressions. In addition, induction of miR‐142‐3p could upregulate tumor suppressor miRNAs, including miR‐330, miR‐145, and miR34a.ConclusionFor the first time, our results revealed that miR‐142‐3p could target Bach‐1in breast cancer cells leading to the reduction of EMT‐related proteins and reduced cell proliferation, invasion, and migration. The results also demonstrated that miR‐142‐3p could regulate important tumor suppressor miRNAs in breast cancer cells. In conclusion, our results suggest that miR‐142‐3p could be a good candidate for the targeted therapy of breast cancer, especially for the invasive type.
Association between microRNAs expression and signaling pathways of inflammatory markers in diabetic retinopathy
Authors: Shafabakhsh Rana , Aghadavod Esmat , Mobini Moein , Heidari‐Soureshjani Reza , Asemi Zatollah 
Published: November 2018

AbstractDiabetic retinopathy is one of the common and serious microvascular complications of diabetes mellitus, as hyperglycemia has metabolic effects on the retina. Hyperglycemia induces increased oxidative stress, which stimulates inflammation pathways and promotes vascular dysfunction of the retina that leads to increased capillary permeability and vascular leakage. One of the main factors involving diabetic retinopathy is the inflammation signaling pathways. In contemporary times, microRNAs (miRNAs) are identified as functional biomarkers for early detection and treatment of numerous diseases specifically diabetic retinopathy. MiRNAs can modulate gene expression through regulation of transcriptional and posttranscriptional of target genes. With that, miRNAs can regulate almost every cellular and developmental process, including the regulation of instinct immune responses and inflammation. The aim of this study is to investigate the role of miRNAs in inflammation pathways and the pathogenesis of diabetic retinopathy.
Isolation and culture of vascular smooth muscle cells from rat placenta
Authors: He Chunyu , Wang Meili , Yan Zi , Zhang Suli , Liu Huirong 
Published: November 2018

AbstractWe developed a new separation method for isolating placental vascular smooth muscle cells (PVSMCs) from a rat in this study. Our method used the magnetic force between a magnet and ferrous ferric oxide (Fe3O
4) to make the separation and extraction processes easier and more efficient. From the first to sixth generation, the cells isolated using this protocol were identified as smooth muscle cells (SMCs) by their immunoreactivity to the SMC markers and by the “hill and valley” morphology. PVSMCs were exposed to angiotensin II (1 μmol/L) and resulted in sharply increased intracellular Ca
2+ concentration. Furthermore, activation of protein kinase C (PKC) increased concomitantly with a decrease in calponin expression. These results indicate that the isolated cells had biological activity. Our method of isolating PVSMCs from rat leads to isolation of cultured cells with activity and high purity. The approach will be useful in research studies on placental vascular diseases.
Synergistic anticancer action of quercetin and curcumin against triple‐negative breast cancer cell lines
Authors: Kundur Sai , Prayag Amrita , Selvakumar Priyanga , Nguyen Hung , McKee Lloyd , Cruz Clairissa , Srinivasan Asha , Shoyele Sunday , Lakshmikuttyamma Ashakumary 
Published: November 2018

AbstractWomen with the breast cancer type 1 susceptibility protein (BRCA1) mutation and loss of BRCA1 expression are reported to have an increased risk of triple‐negative breast cancer (TNBC). Targeting BRCA1 modulation might offer a therapeutic option to treat TNBC patients. Our studies detected that BRCA1 is poorly expressed in TNBC cell lines and highly expressed in ER+ breast cancer cell lines. To modulate BRCA1 expression, we tested two different dietary components to find out if any would induce tumor suppressor genes. We detected that quercetin and curcumin dose‐dependently enhanced the BRCA1 expression. Further, a synergistic action of quercetin and curcumin was observed in modulating the BRCA1 level and in inhibiting the cell survival and migration of TNBC cell lines. Quercetin and curcumin appeared to induce BRCA1 promoter histone acetylation. Furthermore, BRCA1 knockdown induced cell survival and cell migration in ER
+ cells were significantly decreased by the combined treatment of quercetin and curcumin. Our present study concluded that the combination treatment of quercetin and curcumin acts synergistically to induce anticancer activity against TNBC cells by modulating tumor suppressor genes.
Cardiovascular complications and related risk factors underlying opium consumption
Authors: Ebdali Reyhaneh T. , Tabaee Seyyedeh Samaneh , Tabaei Samira 
Published: November 2018

AbstractOpium is considered as the second most abused addictive compound in worldwide. It seems that one of the causes for common consumption of opium in many countries is a traditional belief, even among medical personnel, through which opium might have advantageous influences on cardiovascular events and be beneficial in controlling hypertension, dyslipidemia, and diabetes. According to several investigations, it is thought that opium not only has no beneficial effects on cardiovascular events, but it might have deleterious influences on these settings. As a result, people need to be trained with regard to the adverse effects of opium on cardiovascular events. In this review, we try to go through the understanding of the effects of opium cardiovascular disorders and related complications such as blood pressure, blood sugar, lipid circumstances, and finally atherosclerosis.