bluuebunny/crossref_metadata_2025_split huggingface dataset:
Owner Perception of Outcome Following Permanent Tracheostomy in Dogs
Authors: Davis Anastacia Marie , Grimes Janet A. , Wallace Mandy L. , Vetter Catherine A.M. , Sterman Allyson , Mankin Kelley Thieman , Hlusko Katelyn C. , Matz Brad M. , Lin Samantha , Scharf Valery F. , Cornell Karen K. , Schmiedt Chad W. 
Published: July 2018

ABSTRACT
The purpose of this study was to evaluate owner perception of outcome following permanent tracheostomy (PT) in dogs. Medical records of dogs who received PT from 2002 to 2016 were reviewed. A questionnaire was given to owners verbally or by e-mail to ascertain their perception of their dog’s outcome after PT. Median time to questionnaire administration from PT surgery was 608 days (64–3,708). Owner satisfaction after PT was high (89.7%), with the majority stating they would have the procedure performed again (79.5%). Owners reported an improvement in their dog's personality (30.8%) and increased activity (41%). Median survival time was 1,825 days (64–2,663), with 6 of 39 dogs (15.4%) alive at study end. Of the 33 dogs who died, 11 (33.3%) died from underlying respiratory conditions suspected to be related to the PT. The overall complication rate was 82.1%, with mucus secretion being the most common. Revision surgery was required in 30.8% of dogs (most commonly due to skin occlusion), and aspiration pneumonia occurred in 17.9% of dogs. Overall, owner satisfaction after PT in dogs is high despite intensive postoperative management, and long survival times can be achieved.
De betekenis van het Interbestuurlijk Programma voor het waterbeheer
Authors: Havekes H.J.M. (Herman) 
Published: July 2018

De betekenis van het Interbestuurlijk Programma voor het waterbeheer
In deze bijdrage bespreekt de auteur het Interbestuurlijk Programma voor het waterbeheer, dat op 14 februari 2018 is gepresenteerd.
De Omgevingswet als aanjager voor een nieuwe coördinatieregeling in de Awb
Authors: Beurskens L.R.M.A. (Nard) , Ypinga J.H.N. (Jelmer) , de Graaf K.J. (Kars) 
Published: July 2018

De Omgevingswet als aanjager voor een nieuwe coördinatieregeling in de Awb
Auteurs bespreken het voorstel voor een algemene coördinatieregeling in de Algemene wet bestuursrecht aan de hand van het wetsvoorstel dat op 17 januari 2018 door de regering ter consultatie is aangeboden.
Extraction of Phenylethanoid Glycosides from Cistanche tubulosa by High-Speed Shearing Homogenization Extraction
Authors: Pei Wenjing , Guo Ruili , Zhang Jinli , Li Xueqin 
Published: July 2018

Abstract
Background: Cistanche tubulosa is a well-known traditional Chinese medicine originating in Xinjiang. It is widely distributed in northern Africa, India, etc. Objective: The major bioactive component of C. tubulosa is phenylethanoid glycosides (PhGs). Echinacoside and acteoside are the indicative components for the determination of PhGs and are mainly used for liver protection, immune protection, etc. Therefore, it is very important to extract the PhGs from C. tubulosa. Methods: In this study, the ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and high-speed shearing homogenization extraction (HSHE) methods were compared. Furthermore, the extraction conditions of the HSHE method were optimized. Results: The results showed that the HSHE method was better than both the UAE and MAE methods, and the optimal extraction parameters of HSHE were an ethanol concentration of 50%, an extraction temperature of 70°C, a rotation speed of 16 000 rpm, an extraction time of 2 min, a solid-to-liquid ratio of 1:9, and one extraction cycle. The yields of echinacoside and acteoside were 1.366 and 0.519%, respectively, and the transfer rates of echinacoside and acteoside reached 87 and 94%, respectively. Conclusions: It can be concluded that the HSHE method is a simple, rapid, and efficient technique for extracting PhGs from C. tubulosa. Highlights: An efficient and ecofriendly HSHE method has been investigated for the extraction of PhGs from C. tubulosa. The optimum conditions of the HSHE method for the extraction of PhGs from C. tubulosa were obtained. This research provides a new method for the industrial extraction of PhGs from C. tubulosa.
Uncommon Types of Lung Carcinoma With Mixed Histology: Sarcomatoid Carcinoma, Adenosquamous Carcinoma, and Mucoepidermoid Carcinoma
Authors: Borczuk Alain C. 
Published: July 2018

Context.—
Lung tumors are histologically heterogeneous, but classification of lung carcinoma has prognostic impact and increasingly, specific molecular correlates.

Objective.—
To update the gross, microscopic, and molecular pathology of unusual lung carcinomas to assure accurate classification. In entities with mixed histology, the recognition of specific features or rare patterns is critical to diagnosis. These diagnoses can identify tumors with aggressive clinical behavior, and diagnostic pitfalls can therefore result in underdiagnosis of these already rare entities. Incorrect classification of more indolent tumors into the more aggressive categories can also occur. In the area of molecular pathology, these unusual tumors have a specific spectrum of molecular alterations.

Data Sources.—
PubMed searches for lung and sarcomatoid carcinoma, pleomorphic carcinoma, blastoma, carcinosarcoma, and adenosquamous and mucoepidermoid carcinoma were undertaken and this information was integrated with clinical experience of the author.

Conclusions.—
These uncommon carcinomas have specific clinicopathologic features, and attention to their gross and microscopic pathology leads to classification with important associated molecular findings.
La production du droit autochtone : comportement, commandement, enseignement
Authors: Otis Ghislain 
Published: July 2018

Ce texte présente quelques réflexions sur les modes de production, de détermination, de transformation et de transmission du droit autochtone en marge de l’État. Les systèmes juridiques autochtones ont souvent été refoulés et occultés par les politiques coloniales. Ils ont aussi subi des bouleversements en raison des transformations culturelles et économiques qui ont marqué la vie des sociétés autochtones. En conséquence, il peut être difficile aujourd’hui, surtout pour la société non autochtone, de saisir les processus par lesquels se forment et se transforment les systèmes juridiques autochtones. L’auteur montre d’abord que les cultures juridiques autochtones restent encore aujourd’hui fortement ancrées dans le droit spontané, c’est-à-dire un droit inhérent à la compétence originelle du groupe et donc créé sans l’intervention de l’autorité politique, du juge ou du juriste savant. Il souligne toutefois aussi que l’univers juridique autochtone se trouve de plus en plus confronté à la question de l’autorité et du commandement comme foyers de normes, ce qui pose la question des rapports de pouvoir et de la place du droit écrit ainsi que de sa relation, de tension ou de coopération, avec le droit non écrit. Enfin, l’auteur montre comment la quête de connaissance des traditions juridiques autochtones, la volonté de les revitaliser dans la régulation quotidienne des communautés et le besoin de les rendre plus lisibles pour les non-autochtones, ont induit l’émergence d’une école doctrinale autochtoniste mobilisant les récits et la tradition orale autochtones pour en tirer des enseignements susceptibles d’inspirer des initiatives d’autodétermination plus effectives et légitimes.
Porcupine and Other Stories: Legal Relations in Secwépemcúlecw
Authors: Friedland Hadley , Leonard Bonnie , Asch Jessica , Mortimer Kelly 
Published: July 2018

For thousands of years, Secwépemc laws (like other Indigenous laws) related to the Secwépemc lands, or “Secwépemcúlecw,” developed and were learned and practiced within a context where the personhood of Secwépemc individuals, as well as animals and the earth itself, was not in dispute. Nor was the existence, legitimacy or efficacy of Secwépemc laws. All of these crucial legal relationships still exist, and are ongoing. However, for the past 150 years or so, Secwépemc laws, and people, have lived in relation to something quite distinct — a set of laws that were jurispathic in nature —laws that would not recognize or tolerate any other law but themselves. The Secwépemc Nation’s resilience and perseverance in upholding and revitalizing Secwépemc laws in the face of this colonial disregard, attests to their strength and enduring value. In this article, the authors discuss the purpose, as well as some of the methods, outcomes and limits of the Secwépemc Lands and Resources Laws project produced in collaboration with the University of Victoria Indigenous Law Research Unit. They then examine present interactions between Secwépemc and state land and resources laws operating within Secwépemcúlecw, including the challenges and limited opportunities that exist within the way these legal and political relations are currently structured and implemented on the ground. Finally, they draw on the Secwépemc “Story of Porcupine” to suggest a constructive way forward towards a more mutually respectful Nation-to-Nation relationship between the Secwépemc people and the Canadian State.
Long-term evolution of preferences for conservation projects in the Seto Inland Sea, Japan: a comprehensive analytic framework
Authors: Uehara Takuro , Tsuge Takahiro , Ota Takahiro 
Published: July 2018

BackgroundThe long-term evolution of preferences for nature is crucial to conservation projects, given their targeted long-term horizons. Neglecting to account for this evolution could lead to undesirable human–nature relationships. This study compares the willingness to pay (WTP) for three coastal conservation projects in the Seto Inland Sea, Japan, at two distant time points (1998 and 2015), and tests for temporal transferability. It also compares protest responses that are often overlooked in WTP practices, regardless of their utility for conservation projects.MethodsGiven the lack of a unanimous protocol for protest response analyses and their use in estimating WTP, we propose a comprehensive analytic framework that integrates the two.ResultsWe show that, while preferences for coastal ecosystem services were overall stable and temporarily transferable, the preferences for certain aspects of conservation projects considerably changed.DiscussionThis suggests the need to reconsider the projects’ scheme, not the ecosystem services themselves, along with the clarification of beneficiaries and those responsible for past destruction. We conclude by suggesting further studies with a focus on regions experiencing significant social-ecological changes, such as developing countries, by exploiting the rich asset of existing valuations. This could contribute to the database for more temporal-sensitive ecosystem service valuations utilized for benefit transfers.
Feminismos desde Abya Yala: Ideas y proposiciones de las mujeres de 607 pueblos en nuestra América, de Francesca Gargallo
Authors: Bascur Molina Valentina Paz 
Published: July 2018

Resenha do livro<em> Feminismos desde Abya Yala: Ideas y proposiciones de las mujeres de 607 pueblos en nuestra América</em>, da escritora feminista Francesca Gargallo, como resultado de uma extensa investigação realizada a partir dos encontros e diálogos estabelecidos com mulheres indígenas de diversos povos da América Latina
Pre‐amyloid stage of Alzheimer's disease in cognitively normal individuals
Authors: Tijms Betty M. , Vermunt Lisa , Zwan Marissa D. , van Harten Argonde C. , van der Flier Wiesje M. , Teunissen Charlotte E. , Scheltens Philip , Visser Pieter Jelle ,   for ADNI
Published: July 2018

AbstractObjectiveTo study risk factors for decreasing aβ1–42 concentrations in cerebrospinal fluid (CSF) in cognitively unimpaired individuals with initially normal amyloid and tau markers, and to investigate whether such aβ1–42 decreases are associated with subsequent decline in cognition and other biomarkers of Alzheimer's disease.MethodsCognitively normal subjects (n = 83, 75 ± 5 years, 35(42%) female) with normal CSF aβ1–42 and tau and repeated CSF sampling were selected from ADNI. Subject level slopes of aβ1–42 decreases were estimated with mixed models. We tested associations of baseline APP processing markers (BACE1 activity, aβ1–40, aβ1–38 and sAPPβ) and decreasing aβ1–42 levels by including an interaction term between time and APP marker. Associations between decreasing aβ1–42 levels and clinical decline (i.e., progression to mild cognitive impairment or dementia, MMSE, memory functioning) and biological decline (tau, hippocampal volume, glucose processing and amyloid PET) over a time period of 8–10 years were assessed.ResultsAβ1–42 levels decreased annually with −4.6 ± 1 pg/mL. Higher baseline BACE1 activity (β(se) = −0.06(0.03), P < 0.05), aβ1–40 (β(se)= −0.11(.03), P < 0.001), and aβ1–38 levels (β(se) = −0.11(0.03), P < 0.001) predicted faster decreasing aβ1–42. The fastest tertile of decreasing aβ1–42 rates was associated with subsequent pathophysiological processes: 11(14%) subjects developed abnormal amyloid levels after 3 ± 1.7 years, showed increased risk for clinical progression (Hazard Ratio[95CI] = 4.8[1.1–21.0]), decreases in MMSE, glucose metabolism and hippocampal volume, and increased CSF tau and amyloid aggregation on PET (all P < 0.05).InterpretationHigher APP processing and fast decreasing aβ1–42 could be among the earliest, pre‐amyloid, pathological changes in Alzheimer's disease.
Radical C−H‐Amination of Heteroarenes using Dual Initiation by Visible Light and Iodine
Authors: Lucchetti Nicola , Tkacheva Anastasia , Fantasia Serena , Muñiz Kilian 
Published: July 2018

AbstractA novel light‐induced C−H amination of heteroarenes can be accomplished with preformed iodine(III) reagents as the combined oxidant and nitrogen source. The reaction requires the use of a small amount of molecular iodine, which under photochemical activation generates in situ an iodine(I) reagent as the initiator of the radical amination reaction. A total of 32 examples exemplify the broad scope of the transformation.magnified image
A Modular Assembly of Spinal Cord–Like Tissue Allows Targeted Tissue Repair in the Transected Spinal Cord
Authors: Lai Bi‐Qin , Feng Bo , Che Ming‐Tian , Wang Lai‐Jian , Cai Song , Huang Meng‐Yao , Gu Huai‐Yu , Jiang Bing , Ling Eng‐Ang , Li Meng , Zeng Xiang , Zeng Yuan‐Shan 
Published: July 2018

AbstractTissue engineering–based neural construction holds promise in providing organoids with defined differentiation and therapeutic potentials. Here, a bioengineered transplantable spinal cord–like tissue (SCLT) is assembled in vitro by simulating the white matter and gray matter composition of the spinal cord using neural stem cell–based tissue engineering technique. Whether the organoid would execute targeted repair in injured spinal cord is evaluated. The integrated SCLT, assembled by white matter–like tissue (WMLT) module and gray matter–like tissue (GMLT) module, shares architectural, phenotypic, and functional similarities to the adult rat spinal cord. Organotypic coculturing with the dorsal root ganglion or muscle cells shows that the SCLT embraces spinal cord organogenesis potentials to establish connections with the targets, respectively. Transplantation of the SCLT into the transected spinal cord results in a significant motor function recovery of the paralyzed hind limbs in rats. Additionally, targeted spinal cord tissue repair is achieved by the modular design of SCLT, as evidenced by an increased remyelination in the WMLT area and an enlarged innervation in the GMLT area. More importantly, the pro‐regeneration milieu facilitates the formation of a neuronal relay by the donor neurons, allowing the conduction of descending and ascending neural inputs.
Red Organic Light‐Emitting Diode with External Quantum Efficiency beyond 20% Based on a Novel Thermally Activated Delayed Fluorescence Emitter
Authors: Chen Jia‐Xiong , Wang Kai , Zheng Cai‐Jun , Zhang Ming , Shi Yi‐Zhong , Tao Si‐Lu , Lin Hui , Liu Wei , Tao Wen‐Wen , Ou Xue‐Mei , Zhang Xiao‐Hong 
Published: July 2018

AbstractA novel thermally activated delayed fluorescence (TADF) emitter 12,15‐di(10H‐phenoxazin‐10‐yl)dibenzo[a,c]dipyrido[3,2‐h:2′,3′‐j]phenazine (DPXZ‐BPPZ) is developed for a highly efficient red organic light‐emitting diode (OLED). With rigid and planar constituent groups and evident steric hindrance between electron‐donor (D) and electron‐acceptor (A) segments, DPXZ‐BPPZ realizes extremely high rigidity to suppress the internal conversion process. Meanwhile, the highly twisted structure between D and A segments will also lead to an extremely small singlet–triplet energy split to DPXZ‐BPPZ. Therefore, DPXZ‐BPPZ successfully realizes an efficient fluorescent radiation transition and reverse intersystem crossing process, and possesses an extremely high photoluminescence quantum efficiency of 97.1 ± 1.1% under oxygen‐free conditions. The OLED based on DPXZ‐BPPZ shows red emission with a peak at 612 nm and a Commission Internationale de L'Eclairage (CIE) coordinate of (0.60, 0.40), and it achieves high maximum forward‐viewing efficiencies of 20.1 ± 0.2% (external quantum efficiency), 30.2 ± 0.6 cd A−1 (current efficiency), and 30.9 ± 1.3 lm W−1 (power efficiency). The prepared OLED has the best performance among the reported red TADF OLEDs. These results prove that DPXZ‐BPPZ is an ideal candidate for red TADF emitters, and the designing approach is valuable for highly efficient red TADF emitters.
Advancing the Pharmaceutical Potential of Bioinorganic Hybrid Lipid‐Based Assemblies
Authors: Wang Junqing , Wang Angela Zhe , Lv Peng , Tao Wei , Liu Gang 
Published: July 2018

AbstractBioinspired lipid assemblies that mimic the elaborate architecture of natural membranes have fascinated researchers for a long time. These lipid assemblies have gone from being just an imperative platform for biophysical research to a pharmaceutical delivery system for biomedical applications. Despite success, these organized nanosystems are often subject to the mechanical instability and limited theranostic capability without adding any inconvenient modifications. To reach their advanced pharmaceutical potential, various bioinorganic hybrid lipid‐based assembles, which provide new opportunities to synergistically complement and improve therapeutic/diagnostic potential of existing lipid‐based nanomedicine with distinct mechanisms containing inorganic embedded surfactants, have recently been developed.
All‐Silica Submicrometer Colloidosomes for Cargo Protection and Tunable Release
Authors: Jiang Hang , Hong Liangzhi , Li Yunxing , Ngai To 
Published: July 2018

AbstractColloidosomes have received considerable attention for the controlled delivery of active ingredients in medicine, agrochemicals, and cosmetics. However, most reported colloidosomes are highly permeable and size is larger than 1 μm. All silica colloidosomes have now been prepared with adjustable size, compact shell and low permeability. Our approach is based on the formation of inverse water‐in‐oil (w/o) emulsions stabilized solely by hydrophobic silica nanoparticles and subsequent locking of the particle at the oil–water interface by a simple sol–gel reaction of silica precursor at room temperature. The colloidosomes obtained display a robust and closed shell, ensuring a long‐term retention of small hydrophilic molecules such as Methylene Blue. Remarkably, unlike all other reported silica colloidosomes, a timely and stepwise release of the encapsulated cargo can be triggered by adding ethanol or surfactant without destroying the capsule shell.
A Calixarene‐Based Metal–Organic Framework for Highly Selective NO2 Detection
Authors: Schulz Marcel , Gehl Adrian , Schlenkrich Jakob , Schulze Hendrik A. , Zimmermann Stefan , Schaate Andreas 
Published: July 2018

AbstractA calixarene‐based metal–organic framework (Zr‐cal, [Zr6O4(OH)4(FA)6]2(cal)3], FA=formate, cal=1,3‐alt‐25,26,27,28‐tetrakis[(carboxy)methoxy]calixarene) was synthesized and characterized by single‐crystal X‐ray diffraction. The three‐dimensional framework is a 4,6‐connected network of gar topology and exhibits two equal but nonintersecting three‐dimensional pore systems. It has a specific BET surface area of 670 m2 g−1, and the calixarene cavities are accessible through the pore systems. The exposed calixarenes can be used for the visual detection and encapsulation of NO2 through the formation of deeply colored charge–transfer complexes inside the MOF. The highly selective complexation was analyzed by UV/Vis and IR spectroscopy, and the stability of the material was confirmed by powder X‐ray diffraction and 1H NMR spectroscopy. Finally, the MOF was used as a sensor material in a home‐made sensor cell and showed high sensitivity for NO2.
Enantioselective analysis of lansoprazole in rat plasma by LC–MS/MS: Application to a stereoselective pharmacokinetic study
Authors: Luo Linda , Wen Xiaoli , Du Yueying , Jiang Zhen , Guo Xingjie 
Published: July 2018

AbstractA rapid, sensitive and enantioselective method was developed and fully validated for the separation and determination of lansoprazole enantiomers in rat plasma by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The analytes and the internal standard (esomeprazole) were both extracted from plasma samples by liquid–liquid extraction with diethyl ether–dichloromethane (70:30; v/v). Satisfactory resolution (Rs = 2.0) was achieved within 7.3 min on a Chiralpak ID column (250 × 4.6 mm, 5 μm) employing acetonitrile–water (60:40, v/v) as the mobile phase at a flow rate of 0.6 mL/min. The acquisition of mass spectrometric data was performed in the multiple reaction monitoring mode coupled with a positive electrospray ionization source. A comprehensive validation of this method was rigorously conducted over the concentration range of 1.00–500.0 ng/mL for both enantiomers. All of the validation data demonstrated that the desirable linearity, sensitivity, accuracy, precision, recovery and stability were attained from the proposed approach. The established method was successfully applied to a stereoselective pharmacokinetic study of lansoprazole enantiomers in rat plasma after oral administration of 3 mg/kg racemic lansoprazole or dexlansoprazole. No chiral inversion was observed during the experimental procedure.