bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative Glucagon-Like Peptide-1 Agonist Use and Rates of Pseudarthrosis After Single-Level Lumbar Fusion: A Large Retrospective Cohort Study
Authors: Agrawal Vedant , Amasa Saketh , Karabacak Mert , Margetis Konstantinos 
Published: November 2024

BACKGROUND AND OBJECTIVE:
Pseudarthrosis is a common surgical complication after arthrodesis and is associated with poor clinical outcomes. The association between glucagon-like peptide-1 (GLP-1) agonist use and pseudarthrosis is yet to be explored. This study aims to examine the association of GLP-1 agonists with rates of pseudarthrosis in patients undergoing single-level lumbar fusion.

METHODS:
This national multicenter cohort study used data spanning from June 19, 2010, to June 19, 2024, from the global health network TriNetX. One-to-one propensity score matching for age, sex, race, comorbidities, body mass index, and A1c was conducted to balance cohorts. The rates of pseudarthrosis were then assessed within the 6-month, 1-year, and 2-year postsurgical follow-up periods.

RESULTS:
A total of 37 147 patients who underwent single-level lumbar fusion (mean [SD] age, 59.3 [13.5] years; 47.7% men and 52.3% women) were enrolled in the study. Among these, 712 individuals (1.9%) were identified as GLP-1 agonist users. After propensity score matching, there were 709 patients in each cohort. Patients who took a GLP-1 agonist had lower odds of developing pseudarthrosis 6 months [odds ratio (OR): 0.70, 95% CI: 0.51-0.96], 1 year [OR: 0.68, 95% CI: 0.50-0.91], and 2 years (OR: 0.68, 95% CI: 0.50-0.91) after a posterior lumbar interbody fusion/transforaminal lumbar interbody fusion procedure.

CONCLUSION:
In this cohort study, patients who were prescribed GLP-1 agonists in the perioperative period had reduced rates of pseudarthrosis compared with patients without GLP-1 agonist prescriptions. These findings suggest a potential therapeutic benefit of GLP-1 agonists in enhancing spinal fusion outcomes and warrant further prospective studies to confirm these results and explore the underlying mechanisms.
Noise Trading and Asset Pricing Factors
Authors: Huang Shiyang , Song Yang , Xiang Hong 
Published: November 2024

We demonstrate that a broad set of asset pricing factors/anomalies are significantly exposed to “noise trader risk,” and the noise trader risk is priced in factor premia. We first confirm that mutual funds’ flow-induced trading of factors are uninformed, as they generate a large price impact on factor returns, followed by a complete reversal. We then show that asset pricing factors are subject to flow-driven noise trader risk in that expected variation (covariation) of flow-induced noise trading strongly forecasts variance (covariance) of factor returns. Importantly, factor premia are higher when flow-driven noise trader risk is expected to be more salient. This paper was accepted by Kay Giesecke, finance. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01827 .
Sustainable development and environmental taxation: what future prospects?
Authors: Parente Salvatore Antonello 
Published: November 2024

In an attempt to tackle the environmental imbalances produced by the excesses of the global economy, the great contemporary legal systems are gradually evolving towards remedial intervention models of a different nature, in line with environmental sustainability policies.
To encourage this trend, the OECD has qualified interventions aimed at environmental protection all measures that affect the choices between different technological or consumption alternatives, through the modification of convenience in terms of private costs and benefits.
Within these coordinates, a strategic position is assuming environmental taxation which, supported by a widespread cultural orientation, can help to prevent, eliminate or reduce polluting activities through a complex of taxes, tariffs, fees, contributions and other services imposed owed by the polluting manufacturer or user. In this context, the role of environmental taxation can be truly decisive to discourage pollution. Environmental taxes and eco-incentives are frequently used by the Member States, whose domestic laws give more importance to “green taxation”, inspired by EU principles. For the future, we can hope for greater coordination of environmental taxation within the EU, through a rethinking of it, with a view to improving European integration policies in order to develop a uniform response to the current economic-financial crisis and favor economic growth.
Some remarks on protection of cultural and natural heritage in the light of threats posed by tourism
Authors: Pływaczewski Wiesław , Narodowska Joanna , Duda Maciej 
Published: November 2024

The paper addresses the issue of protecting cultural and natural heritage from the threats posed by mass tourism. The authors justify the need for research on this phenomenon and point out the role of green criminology in this area. They subsequently define the basic concepts related to tourism, tourism crime and tourism pathologies. Furthermore, referring to the theoretical achievements of criminology, the authors attempt to explain the etiology of such deeds. The article reviews selected threats against cultural and natural heritage associated with mass tourism, occurring on a local, national, regional and global scale. Based on a review of literature, research results and an analysis of applied legal, institutional and social solutions, the authors propose possibilities of counteracting this phenomenon.
Deliberative Democracy – International Discourse
Authors: Sokalska Edyta 
Published: November 2024

In the 21st century, dissatisfaction with the democratic arrangements contributed to the arousing curiosity about the improvement of representative democracy. Modern forms of political organization consider alternative ways of arranging the state. Deliberative democracy is the idea which became popular with the researchers in their theoretical considerations at the turn of the 20th and 21st centuries. It is also seen as a lucrative proposal to enrich and improve the mechanism accompanying the operation of the universal model of representative democracy. However, it should be taken into closer consideration that its solutions and postulates raise a number of questions and doubts, specifically as regards their applicability in practice. Scientific debate referring to the development of deliberative democracy did not establish any unified schools or currents. The discourse is internally diverse, however four generations of deliberative democracy might be identified. The ‘systemic turn’ exposes development and promotion of deliberation on a mass scale, emphasis on the division of activities and tasks of participants within the system, and – in order to link multiplicity of institutions and the processes that occur among them – application of a certain continuum to the criterion of deliberation.
Social support of mothers of children with epilepsy
Authors: Kręcisz-Plis Elżbieta 
Published: November 2024

Analysis of the literature on the subject leads to the conclusion that the issue of functioning of families with chronically ill children is an area that does not attract much interest from researchers. In the context of Polish literature, there are few studies concerning the situation of families with children suffering from epilepsy, especially regarding the identification of needs for support in coping with the consequences of the illness. The aim of the presented research was to draw attention to the situation of mothers of children with epilepsy, as the primary caregivers of the sick child, and to the social support they can rely on in the face of difficult situations. The research utilized the Berlin Social Support Scales by Schwarzer and Schulz, in the Polish adaptation by Łuszczyńska and others, which were used to determine the intensity of support perceived by the surveyed mothers, their reported need for support, the support they are currently receiving, and their search for support.
The Essence of Democracy in the Teaching of John Paul II
Authors: Romanko Agnieszka 
Published: November 2024

The study attempts to synthetically present the essence of democracy in the teaching of Pope John Paul II. The Bishop of Rome pointed out that authentic democracy is possible only in a state of law and based on a correct conception of the human person. He warned against ethical relativism, according to which it is wrongly assumed that objective moral norms lead to authoritarianism.
Routine measurement of cardiometabolic disease risk factors in primary care in England before, during, and after the COVID-19 pandemic: A population-based cohort study
Authors: Ho Frederick K. , Dale Caroline , Mizani Mehrdad A. , Bolton Thomas , Pearson Ewan R. , Valabhji Jonathan , Delles Christian , Welsh Paul , Nakada Shinya , Mackay Daniel , Pell Jill P. , Tomlinson Chris , Petersen Steffen E. , Bray Benjamin , Ashworth Mark , Rahimi Kazem , Mamas Mamas , Halcox Julian , Sudlow Cathie , Sofat Reecha , Sattar Naveed ,   CVD-COVID-UK/COVID-IMPACT Consortium
Published: November 2024

Background
This study estimated to what extent the number of measurements of cardiometabolic risk factors (e.g., blood pressure, cholesterol, glycated haemoglobin) were impacted by the COVID-19 pandemic and whether these have recovered to expected levels.

Methods and findings
A cohort of individuals aged ≥18 years in England with records in the primary care—COVID-19 General Practice Extraction Service Data for Pandemic Planning and Research (GDPPR) were identified. Their records of 12 risk factor measurements were extracted between November 2018 and March 2024. Number of measurements per 1,000 individuals were calculated by age group, sex, ethnicity, and area deprivation quintile. The observed number of measurements were compared to a composite expectation band, derived as the union of the 95% confidence intervals of 2 estimates: (1) a projected trend based on data prior to the COVID-19 pandemic; and (2) an assumed stable trend from before pandemic. Point estimates were calculated as the mid-point of the expectation band.
A cohort of 49,303,410 individuals aged ≥18 years were included. There was sharp drop in all measurements in March 2020 to February 2022, but overall recovered to the expected levels during March 2022 to February 2023 except for blood pressure, which had prolonged recovery. In March 2023 to March 2024, blood pressure measurements were below expectation by 16% (−19 per 1,000) overall, in people aged 18 to 39 (−23%; −18 per 1,000), 60 to 79 (−17%; −27 per 1,000), and ≥80 (−31%; −57 per 1,000). There was suggestion that recovery in blood pressure measurements was socioeconomically patterned. The second most deprived quintile had the highest deviation (−20%; −23 per 1,000) from expectation compared to least deprived quintile (−13%; −15 per 1,000).

Conclusions
There was a substantial reduction in routine measurements of cardiometabolic risk factors following the COVID-19 pandemic, with variable recovery. The implications for missed diagnoses, worse prognosis, and health inequality are a concern.
STEED: A data mining tool for automated extraction of experimental parameters and risk of bias items from in vivo publications
Authors: Zurrer Wolfgang Emanuel , Cannon Amelia Elaine , Ewing Ewoud , Brüschweiler David , Bugajska Julia , Hild Bernard Friedrich , Rosso Marianna , Reich Daniel Salo , Ineichen Benjamin Victor 
Published: November 2024

Background and methods
Systematic reviews, i.e., research summaries that address focused questions in a structured and reproducible manner, are a cornerstone of evidence-based medicine and research. However, certain steps in systematic reviews, such as data extraction, are labour-intensive, which hampers their feasibility, especially with the rapidly expanding body of biomedical literature. To bridge this gap, we aimed to develop a data mining tool in the R programming environment to automate data extraction from neuroscience in vivo publications. The function was trained on a literature corpus (n = 45 publications) of animal motor neuron disease studies and tested in two validation corpora (motor neuron diseases, n = 31 publications; multiple sclerosis, n = 244 publications).

Results
Our data mining tool, STEED (STructured Extraction of Experimental Data), successfully extracted key experimental parameters such as animal models and species, as well as risk of bias items like randomization or blinding, from in vivo studies. Sensitivity and specificity were over 85% and 80%, respectively, for most items in both validation corpora. Accuracy and F1-score were above 90% and 0.9 for most items in the validation corpora, respectively. Time savings were above 99%.

Conclusions
Our text mining tool, STEED, can extract key experimental parameters and risk of bias items from the neuroscience in vivo literature. This enables the tool’s deployment for probing a field in a research improvement context or replacing one human reader during data extraction, resulting in substantial time savings and contributing towards the automation of systematic reviews.
Antibiotic use prior to attending a large diarrheal disease hospital among preschool children suffering from bloody or non-bloody diarrhea: A cross-sectional study conducted in Bangladesh
Authors: Bashar Syed Jayedul , Islam Md. Ridwan , Nuzhat Sharika , Amin Rukaeya , Rahman Md. Mushfiqur , Pavlinac Patricia B. , Arnold Samuel L. M. , Newlands Amy , Ahmed Tahmeed , Chisti Mohammod Jobayer 
Published: November 2024

Background
Among diarrheal children, injudicious use of antibiotics is a major public health concern particularly in low- and middle-income countries. There are evidence-based guidelines by the World Health Organization (WHO) to prescribe antibiotics for bloody diarrhea in children. There is a scarcity of published data regarding the judicious use of antibiotics for bloody diarrhea in children. So, we aimed to evaluate the presenting features of bloody diarrhea at hospital with prior antibiotic use at home and the prevalence of injudicious antibiotic use for bloody diarrhea in children.

Methods
We screened 7,289 children aged 24–59 months with diarrhea (≥3 loose stools in the last 24 h) at Dhaka Hospital, International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), from December 5, 2021 to February 16, 2023. Antibiotic intake at home due to current diarrheal illness was evaluated and confirmed by direct observation of a prescription, the bottle of antibiotics, or asking the caregiver about the name of antibiotics.

Results
Out of 7,289 children presented with diarrhea, 3,823 (52.45%) children consumed antibiotics before visiting hospital. 254 (3.48%) children presented with bloody diarrhea, among which 162 ingested antibiotics. Among 162 children, 88 (54.32%) received inappropriate antibiotics due to bloody diarrhea, according to the WHO guidelines. The most prevalent single antibiotic consumed in bloody diarrhea was metronidazole (n = 45, 27.78%), followed by ciprofloxacin (n = 39, 24.07%) and azithromycin (n = 32, 19.75%). After adjusting for relevant covariates like age, sex, presence of straining/tenesmus, fever during admission, history of cough, stunting, wasting, and underweight; children suffering from bloody diarrhea had 1.55 times higher odds of using metronidazole alone or in combination with other antibiotics (aOR:1.55, 95% CI: 1.10–2.19, p-value = 0.012) and 1.93 times higher odds of using multiple antibiotics (aOR:1.93, 95% CI: 1.23–3.02, p-value = 0.004) compared to children with non-bloody diarrhea.

Conclusion
The study underscores the excessive use of antimicrobials among children with diarrheal illnesses. It is also evident that metronidazole use and multiple antibiotic use are increasing among children due to bloody diarrhea, which is alarming and calls for antibiotic stewardship by regulating bodies in the country.
Knowledge mobilisation of rapid evidence reviews to inform health and social care policy and practice in a public health emergency: Appraisal of the Wales COVID-19 Evidence Centre processes and impact, 2021–23
Authors: Gal Micaela , Cooper Alison , Joseph-Williams Natalie , Doe Elizabeth , Lewis Ruth , Law Rebecca Jane , Anstey Sally , Davies Nathan , Walters Amy , Orford Robert , Collins Brendan , Trigg Lisa , Roberts Chris , Meredith Sarah , Macey Steven , Carson-Stevens Andrew , Greenwell Jane , Coomber Ffion , Edwards Adrian 
Published: November 2024

Background
The Wales COVID-19 Evidence Centre (WCEC) was established from 2021–23 to ensure that the latest coronavirus (COVID-19) relevant research evidence was readily available to inform health and social care policy and practice decision-makers. Although decisions need to be evidence-based, ensuring that accessible and relevant research evidence is available to decision-makers is challenging, especially in a rapidly evolving pandemic environment when timeframes for decision-making are days or weeks rather than months or years. We set up knowledge mobilisation processes to bridge the gap between evidence review and informing decisions, making sure that the right information reaches the right people at the right time.

Aims and objectives
To describe the knowledge mobilisation processes used by the WCEC, evaluate the impact of the WCEC rapid evidence reviews, and share lessons learned.

Methods
Our knowledge mobilisation methods were flexible and tailored to meet stakeholders’ needs. They included stakeholder co-production in our rapid evidence review processes, stakeholder-informed and participatory knowledge mobilisation, wider dissemination of outputs and associated activities including public engagement, capacity building and sharing of methodologies. Feedback on processes and evidence of impact was collected via stakeholder engagement and a stakeholder survey.

Results
Findings indicate that knowledge mobilisation processes successfully enabled use of the WCEC’s rapid evidence reviews to inform policy and practice decision-makers during the COVID-19 pandemic in Wales. Realising actual public and patient benefit from this ‘pathway to impact’ work will take further time and resources.

Discussion and conclusion
The WCEC knowledge mobilisation processes successfully supported co-production and use of rapid evidence review findings by scientific advisors and policy and practice decision-makers during the COVID-19 pandemic. Identified barriers and facilitators are of potential relevance to wider evidence initiatives, for setting up similar Centres during crisis situations, and supporting future evidence-based policy and practice decision-making.
Screening of prognostic core genes based on cell–cell interaction in the peripheral blood of patients with sepsis
Authors: Li Shaolan , Chen Wenhao , Zhang Zhihong , Yuan Ling , Hu Yingchun , Chen Muhu 
Published: November 2024

Abstract
Peripheral blood samples from 15 septic patients admitted within 24 h and 8 healthy volunteers were used to conduct RNA-seq. Quantitative PCR of THP1 cells was performed to investigate the expression levels of the selected key genes. A total of 1,128 differential genes were identified, 721 of which were upregulated and 407 were downregulated. These genes are mainly involved in neutrophil activation, T cell regulation, immune effector process regulation, cytokine receptor activity, and cytokine binding. The six target genes were ELANE, IL1R2, RAB13, RNASE3, FCGR1A, and TLR5. In the sepsis group, FCGR1A and TLR5 were positively associated with survival compared to ELANE, IL1R2, RAB13, and RNASE3, which were adversely associated with survival. Furthermore, a meta-analysis based on public databases revealed an increased expression of these six target genes in the peripheral blood of patients with sepsis. In addition, we discovered that monocytes primarily express these genes. Using qPCR, we confirmed that these six important genes were highly expressed in lipopolysaccharide-treated THP1 cells. In summary, these findings suggest that ELANE, IL1R2, RAB13, RNASE3, FCGR1A, and TLR5 may influence the prognosis of patients with sepsis and provide novel insights and potential avenues for the treatment of sepsis.
Mine underground object detection algorithm based on TTFNet and anchor-free
Authors: Song Zhen , Qing Xuwen , Zhou Meng , Men Yuting 
Published: November 2024

Abstract
To solve the problem of poor object detection effect caused by uneven light and high noise in underground mines, this study proposes a TTFNet (training-time-friendly network)-based object detection algorithm for underground mines. First, CenterNet and TTFNet algorithms are introduced, then pooling is introduced into CSPNet basic structure to design a lightweight feature extraction network, at the same time optimizing the feature fusion way in the original algorithm, optimizing residual shrinkage network structure, and introducing it into object detection task. Experiments were conducted on the established underground data set. The results show that compared with the original algorithm, our proposed algorithm can still maintain similar accuracy while significantly reducing model parameters; compared with other anchor-based detection algorithms, it has achieved similar overall performance.
Becoming-with in Anicka Yi’s Artistic Practice
Authors: Capurro Edoardo 
Published: November 2024

Abstract
The intent of this article is to investigate the works of Anicka Yi, looking for the elements that make this artist a primary figure in the artistic redefinition of the category of human and the boundary that divides it from everything that is more than human. After a short introduction, the theoretical aspects expressed by philosophers, anthropologists or academics of other disciplines such as Bruno Latour, Isabelle Stengers and Donna Haraway are analyzed to define the worlding, the central theme of this paper. At that point, the artist and her practice are introduced, and then, the Metaspore exhibition of 2022, in which the four works examined in this article are present. These: Le Pain Symbiotique, When Species Meet Part 2 (Vegetable Psychology), Releasing The Human From The Human and Biologizing The Machine (Spillover Zoonotica), are then presented and studied, combining the artistic process with theoretical concepts by Anna L. Tsing, Rosi Braidotti, Marylin Strathern and Elizabeth Povinelli among others. The article, therefore, attempts to highlight how Yi’s works and artistic making are particularly effective examples of worlding, becoming-with of human and more than human. Works are both a new perspective of investigation on life and a new urgent posture toward the future in the era of the Anthropocene.
Fractional Sturm-Liouville operators on compact star graphs
Authors: Mutlu Gökhan , Uğurlu Ekin 
Published: November 2024

Abstract
In this article, we examine two problems: a fractional Sturm-Liouville boundary value problem on a compact star graph and a fractional Sturm-Liouville transmission problem on a compact metric graph, where the orders

α

i

{\alpha }_{i}

of the fractional derivatives on the ith edge lie in

(

0
,
1

)

(0,1)

. Our main objective is to introduce quantum graph Hamiltonians incorporating fractional-order derivatives. To this end, we construct a fractional Sturm-Liouville operator on a compact star graph. We impose boundary conditions that reduce to well-known Neumann-Kirchhoff conditions and separated conditions at the central vertex and pendant vertices, respectively, when

α

i

→
1

{\alpha }_{i}\to 1

. We show that the corresponding operator is self-adjoint. Moreover, we investigate a discontinuous boundary value problem involving a fractional Sturm-Liouville operator on a compact metric graph containing a common edge between the central vertices of two star graphs. We construct a new Hilbert space to show that the operator corresponding to this fractional-order transmission problem is self-adjoint. Furthermore, we explain the relations between the self-adjointness of the corresponding operator in the new Hilbert space and in the classical

L

2

{L}^{2}

space.