bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic Characterization of ERBB2-Driven Biliary Cancer and a Case of Response to Ado-Trastuzumab Emtansine
Authors: Mondaca Sebastian , Razavi Pedram , Xu Chongrui , Offin Michael , Myers Mackenzie , Scaltriti Maurizio , Hechtman Jaclyn F. , Bradley Mikaela , O’Reilly Eileen M. , Berger Michael F. , Solit David B. , Li Bob T. , Abou-Alfa Ghassan K. 
Published: October 2019

PURPOSE Biliary tract cancers (BTCs), which include intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (EHC), and gallbladder cancer (GBC), have limited treatment options. We sought to comprehensively examine the clinical and molecular characteristics of BTCs with amplification or mutation of ERBB2. METHODS Demographic, outcome, and treatment response data were collected for patients with ERBB2-altered BTC identified by next-generation sequencing with Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets from 2014 to 2018. RESULTS A total of 517 patients with BTC underwent next-generation sequencing (ICC, n = 313; EHC, n = 93; GBC, n = 111). Twenty-eight patients (5.4%) had ERBB2 alterations, including 2.7% with ERBB2 gene amplification, 2.3% with ERBB2 mutation, and 0.4% with concurrent amplification and mutation. The prevalence of ERBB2 gene alterations was significantly higher in GBC (12.6%) than in ICC (2.2%) and EHC (7.5%; P < .001). In ERBB2-amplified tumors, the median fold change was 6.4 (range, 2.1 to 19.7), while in ERBB2-mutant tumors, the most frequent mutated domain was the extracellular domain (32%), with all mutations in this region involving the S310 codon. Frequent co-altered genes in this cohort were TP53 (54%), PIK3CA (21%), and CDKN2A (18%); KRAS amplification/mutation was found in 7% of patients. One patient with ERBB2-amplified EHC who enrolled in a basket trial (ClinicalTrials.gov identifier: NCT02675829 ) had a partial response to the human epidermal growth factor receptor 2–targeted antibody-drug conjugate ado-trastuzumab emtansine. CONCLUSION ERBB2 alterations are present in 5.4% of BTCs. When present, the degree of ERBB2 gene amplification is often high, and S310 codon mutations are the most common hotspot. These features, along with the presented case, support further development of human epidermal growth factor receptor 2–targeted therapy in ERBB2-mutant and/or -amplified BTC.
Beyond the Confederacy
Authors: James-Chakraborty Kathleen 
Published: October 2019

Abstract
Monument Avenue in Richmond, Virginia, contains the United States’ most comprehensive and controversial set of memorials commemorating the Confederacy. In the late nineteenth and early twentieth centuries, women as well as men from families that had formerly owned slaves enjoyed roles as public figures by working to keep the memory of the Confederacy alive, including by championing the erection of statues like these. This activism helped enable subsequent female family members to become public intellectuals and scholars. Scholarship on the origins of the approach enshrined in a celebrated series of memorials erected in Berlin following German reunification by one such woman suggests that Richmond’s series of monuments might be reconfigured to foster a more inclusive approach to the history of the Civil War by sharply contrasting fragments of the current memorials with new content that addresses African American and other Unionist perspectives on the conflict.
Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable
Authors: CAMPBELL KRISTIN L. , WINTERS-STONE KERRI M. , WISKEMANN JOACHIM , MAY ANNE M. , SCHWARTZ ANNA L. , COURNEYA KERRY S. , ZUCKER DAVID S. , MATTHEWS CHARLES E. , LIGIBEL JENNIFER A. , GERBER LYNN H. , MORRIS G. STEPHEN , PATEL ALPA V. , HUE TRISHA F. , PERNA FRANK M. , SCHMITZ KATHRYN H. 
Published: October 2019

ABSTRACT

Purpose
The number of cancer survivors worldwide is growing, with over 15.5 million cancer survivors in the United States alone—a figure expected to double in the coming decades. Cancer survivors face unique health challenges as a result of their cancer diagnosis and the impact of treatments on their physical and mental well-being. For example, cancer survivors often experience declines in physical functioning and quality of life while facing an increased risk of cancer recurrence and all-cause mortality compared with persons without cancer. The 2010 American College of Sports Medicine Roundtable was among the first reports to conclude that cancer survivors could safely engage in enough exercise training to improve physical fitness and restore physical functioning, enhance quality of life, and mitigate cancer-related fatigue.

Methods
A second Roundtable was convened in 2018 to advance exercise recommendations beyond public health guidelines and toward prescriptive programs specific to cancer type, treatments, and/or outcomes.

Results
Overall findings retained the conclusions that exercise training and testing were generally safe for cancer survivors and that every survivor should “avoid inactivity.” Enough evidence was available to conclude that specific doses of aerobic, combined aerobic plus resistance training, and/or resistance training could improve common cancer-related health outcomes, including anxiety, depressive symptoms, fatigue, physical functioning, and health-related quality of life. Implications for other outcomes, such as peripheral neuropathy and cognitive functioning, remain uncertain.

Conclusions
The proposed recommendations should serve as a guide for the fitness and health care professional working with cancer survivors. More research is needed to fill remaining gaps in knowledge to better serve cancer survivors, as well as fitness and health care professionals, to improve clinical practice.
American College of Sports Medicine Roundtable Report on Physical Activity, Sedentary Behavior, and Cancer Prevention and Control
Authors: PATEL ALPA V. , FRIEDENREICH CHRISTINE M. , MOORE STEVEN C. , HAYES SANDRA C. , SILVER JULIE K. , CAMPBELL KRISTIN L. , WINTERS-STONE KERRI , GERBER LYNN H. , GEORGE STEPHANIE M. , FULTON JANET E. , DENLINGER CRYSTAL , MORRIS G. STEPHEN , HUE TRISHA , SCHMITZ KATHRYN H. , MATTHEWS CHARLES E. 
Published: October 2019

ABSTRACT

Introduction
The American College of Sports Medicine convened an International Multidisciplinary Roundtable on Exercise and Cancer in March 2018 to evaluate and translate the evidence linking physical activity and cancer prevention, treatment, and control. This article discusses findings from the Roundtable in relation to the biologic and epidemiologic evidence for the role of physical activity in cancer prevention and survival.

Results
The evidence supports that there are a number of biologically plausible mechanisms, whereby physical activity can influence cancer risk, and that physical activity is beneficial for the prevention of several types of cancer including breast, colon, endometrial, kidney, bladder, esophageal, and stomach. Minimizing time spent in sedentary behavior may also lower risk of endometrial, colon and lung cancers. Conversely, physical activity is associated with higher risk of melanoma, a serious form of skin cancer. Further, physical activity before and after a cancer diagnosis is also likely to be relevant for improved survival for those diagnosed with breast and colon cancer; with data suggesting that postdiagnosis physical activity provides greater mortality benefits than prediagnosis physical activity.

Conclusions
Collectively, there is consistent, compelling evidence that physical activity plays a role in preventing many types of cancer and for improving longevity among cancer survivors, although the evidence related to higher risk of melanoma demonstrates the importance of sun safe practices while being physically active. Together, these findings underscore the importance of physical activity in cancer prevention and control. Fitness and public health professionals and health care providers worldwide are encouraged to spread the message to the general population and cancer survivors to be physically active as their age, abilities, and cancer status will allow.
ТРЕТЬЯ ФУНКЦИЯ УНИВЕРСИТЕТА: ПОТРЕБНОСТЬ ИЛИ ОБЯЗАННОСТЬ
Authors: Мальковец Наталья Владимировна 
Published: October 2019

Статья посвящена третьей функции университета (вуза), связанной с взаимодействием с обществом, в том числе, местным сообществом, властью и бизнесом, дополняющей такие функции, как образовательная и научно- исследовательская. Автор поднимает такие проблемы, как непонимание сущности и важности третьей функции среди преподавателей и руководителей образовательных учреждений, отсутствие сформированной потребности и мотивации для развития взаимодействия, нормативных актов, обязывающих образовательное учреждение интегрироваться в местное сообщество, и другие. Между тем, реализация третьей функции открывает новые возможности для научной, исследовательской, педагогической и образовательной деятельности вуза. Научная и практическая работа автора позволили сформулировать рекомендации для дальнейшего развития третьей функции университета: создание центра, изучение успешного опыта, проведение проектных сессий, объединение наиболее активных вузов для защиты своих прав и т.д.
Inovação e pesquisa no setor automotivo de Pernambuco: o caso do Centro de Pesquisa, Desenvolvimento, Inovação e Engenharia da FCA (FIAT-Chrysler Automobile)
Authors: Rodrigues Lima João Policarpo , Sicsú Abraham Benzaquen 
Published: October 2019

A recente inauguração da fábrica de automóveis da FIAT-CHRYSLER AUTOMOBILE – FCA, no município de Goiana, abre enormes perspectivas de ampliação do setor industrial de Pernambuco para além da região situada no entorno mais próximo do distrito industrial portuário de Suape, bem como permite antever a possibilidade do estabelecimento de uma maior articulação do segmento automobilístico com outros segmentos e empresas pré-existentes e a serem atraídos para integração com o segmento motriz. Ao lado do segmento automobilístico de óbvia importância, já existe no território uma base significativa de pesquisadores e instituições de suporte tecnológico, além de um segmento de TI formado por um bom número de empresas aglomeradas no Porto Digital, no Recife, mas também em outros municípios, como é o caso de Olinda. Essa conjunção de uma base razoavelmente significativa de C, T&I já disponível no território com a instalação de uma montadora com tecnologia de ponta do ponto de vista mundial gerou expectativas de formação no Estado de Pernambuco de um polo dinâmico de desenvolvimento tecnológico, abrangendo as competências já existentes com a interação com a FCA e um Centro de Desenvolvimento Tecnológico que se pretendia de Classe Mundial. Tal Centro, imaginava-se, seria um diferencial para um Estado do Nordeste subdesenvolvido num país ainda em vias de desenvolvimento. Essa expectativa otimista está sendo arrefecida pela crise da economia brasileira e mundial, além de mudanças no próprio quadro político e econômico do Estado, o que, no mínimo, poderá adiar a constituição plena do Centro referido e de seus efeitos dinâmicos. Cabe ressaltar que essa é uma estratégia de longo prazo, mas que, em tempos de crise, ocorrem retrocessos e pode haver uma tendência de concentração da pesquisa estratégica nos centros já consolidados. O que parece é que, com a ocorrência de crises, as economias periféricas, portanto mais frágeis, tornam-se menos atrativas para investimentos de maior risco. Reconhece-se a importância que o Centro vem tendo para o Estado e os impactos significativos em sua economia, mas, chama-se a atenção para mudanças significativas que o projeto inicial vem sofrendo. Este trabalho objetiva avaliar a viabilidade da instalação do Centro de acordo com o previsto, encontrar possíveis explicações para a já detectada mudança de planos e mostrar as dificuldades e fragilidades de economias em desenvolvimento no sentido de avançar no quesito capacitação tecnológica e de vir a ter uma dinâmica tecnológica autônoma, a exemplo de alguns outros países fora do chamado “Centro” desenvolvido, que já superaram essas dificuldades.
Evolution of the slopes of ST2 and galectin-3 during marathon and ultratrail running compared to a control group
Authors: Le Goff Caroline , Kaux Jean-François , Farre Segura Jordi , Stojkovic Violeta , Ancion Arnaud , Seidel Laurence , Lancellotti Patrizio , Cavalier Etienne 
Published: October 2019

Abstract

Background
Previous studies have suggested that exercising may induce cardiac damage. Galectin-3 (Gal-3) and soluble suppression of tumorigenicity 2 (ST2) are very interesting biomarkers for heart failure and myocardial fibrosis. We aimed to compare the kinetics of emerging fibrosis cardiac biomarkers as Gal-3 and ST-2 in endurance runners, and recreational runners before and after a running event represented by a marathon and an ultratrail event.

Methods
Blood samples were taken from 19 healthy non-elite marathon runners (42 km), 27 ultratour runners (67 km), and 14 recreational runners who represented the control group (10 km) just before the run (T0), just after (T1) and 3 h after (T2), in order to analyze Gal-3, ST2, hsTnT, NT-proBNP, CKMB and hsCRP. We compared the percentage of evolution and the slopes obtained from T0 to T1 (pT0T1) and from T1 to T2 (pT1T2), between the different groups of runners participating in three different races.

Results
Plasma cardiac biomarker concentrations increased significantly from baseline to immediately post-exercise and most of the time decreased over the subsequent 3-h period. For pT0T1 and pT1T2, the markers Gal-3 and ST2 showed a significant difference between types of run (p < 0.05 and p < 0.0001, respectively). During the recovery time, Gal-3 returned to the baseline values but not ST2 which continued to increase.

Conclusions
Gal-3 and ST2 are considered as a reflection of cardiac fibrosis and remodeling. The evolution of both was different, particularly after the recovery time. ST2 values exceeding cutoff values at any time.
The Gradient Discretisation Method for Linear Advection Problems
Authors: Droniou Jérôme , Eymard Robert , Gallouët Thierry , Herbin Raphaèle 
Published: October 2019

Abstract
We adapt the Gradient Discretisation Method (GDM), originally designed for elliptic and parabolic partial differential equations, to the case of a linear scalar hyperbolic equations.
This enables the simultaneous design and convergence analysis of various numerical schemes, corresponding to the methods known to be GDMs, such as finite elements (conforming or non-conforming, standard or mass-lumped), finite volumes on rectangular or simplicial grids, and other recent methods developed for general polytopal meshes.
The scheme is of centred type, with added linear or non-linear numerical diffusion.
We complement the convergence analysis with numerical tests based on the mass-lumped

ℙ
1

{\mathbb{P}_{1}}

conforming and non-conforming finite element and on the hybrid finite volume method.
An investigation of vitamin and mineral supplement recommendation among first-trimester pregnancies
Authors: Güler Buse , Bilgiç Dilek , Okumuş Hülya , Yağcan Hande , Alan Murat 
Published: October 2019

Abstract

Background
Healthy and balanced nutrition in pregnancy can affect the mother’s and the fetus’ health. Therefore, health professionals should provide information about this issue to pregnant women. The aim of the study was to examine the rate of vitamin and mineral supplement recommendation among first-trimester pregnant women.

Methods
The study sample consisted of 697 first-trimester pregnant women between 18 and 40 years of age. The pregnant women who registered to an obstetric outpatient clinic between January and June 2018 were retrospectively reviewed, and data were collected from patient medical records using a questionnaire.

Results
Physician’s laboratory test orders from the women included the following: ferritin was 18.4%, mean corpuscular hemoglobin (MCH) was 99.7%, folic acid was 10.2%, vitamin D was 6.3%, vitamin B12 was 17.2% and calcium was 20.4%. All of the women’s hemoglobin levels had been examined. A total of 58.8% of the women were recommended to take folic acid, 32.7% iron, 25.7% iodine, 18.8% calcium, 17.2% vitamin A, 21.1% vitamin B12, 17.4% vitamin C, 31.6% vitamin D and 17.5% vitamin E supplements.

Conclusion
It was determined that ferritin, vitamins B12 and D, calcium, folic acid, iron and iodine levels were not examined routinely in this study. Folic acid and iron supplementation were the most commonly suggested nutrient supplements in the first trimester.
The Dialectic of Sin and Faith in “Being Able to be Oneself”
Authors: Zunic Nikolaj 
Published: October 2019

Abstract
Kierkegaard understands the human self as a process of becoming that is situated in a dialectical relation between sin and faith. The chief task of each human being is to become a true self, instead of assuming a fraudulent identity. This authentic selfhood is grounded in the possibility to be oneself, a condition that is established in faith. Yet this achievement of true selfhood presupposes a state of sin in which the self is regarded as necessarily existing. Thus the aim of this essay is to demonstrate how Kierkegaard argues for a novel modern conception of the self as a dynamic interplay between possibility and necessity, sin and faith, in his attempt to respond to the spiritlessness of his age by vindicating the truth of Christianity.
Simple separation of 67Cu from bulk zinc by coprecipitation using hydrogen sulfide gas and silver nitrate
Authors: Ohya Tomoyuki , Nagatsu Kotaro , Hanyu Masayuki , Minegishi Katsuyuki , Zhang Ming-Rong 
Published: October 2019

Abstract
Copper-67 (67Cu), a feasible radionuclide for diagnosis and radiotherapy, is commercially generated from a bulk zinc (Zn) target using the 68Zn(p, 2p)67Cu and 68Zn(γ, p)67Cu nuclear reactions. Because it uses a large amount of zinc, the separation is complex – requiring a combination of three ion exchange columns – and is time-consuming (about 1 day). We developed a quick and easy separation method referred to as “double coprecipitation” using H2S gas and silver nitrate as coprecipitation agents in place of ion exchange columns. We compared this method with a conventional separation method using three ion exchange columns (AG50W-X8, AG1-X8, and Chelex-100) for a natural zinc (natZn) target irradiated by a proton beam. The product quality and the recovery rate with the new method were competitive with the conventional method, and the total operation time was reduced from 1 day to <3 h.
Effect of temperature, pressure and power in obtaining TiO2 and TiO2-Fe via microwaves and evaluation of photocatalytic activity with synthesis time
Authors: Zurita Luna Ulises , Zárate Medina Juan , Gallegos Hernández Anayeli Yazmin , Romero Toledo Rafael , Cortés José Apolinar 
Published: October 2019

Photocatalysts of titanium dioxide (TiO2) doped with different percentages of iron were synthesized via microwave at 180 °C, with two different times, 2 min and 10 min. Temperature, pressure, and power change were analyzed. Important changes were mainly observed in the pressure conditions. The synthesized photocatalysts were characterized using: Scanning electron microscopy (SEM), X-ray diffraction (XRD), specific surface area (BET), and UV-vis diffuse reflectance spectroscopy. The presence of nanoparticles was observed; furthermore, anatase crystalline phase of TiO2 was the only found. A study of the photocatalytic activity for discoloration acid blue dye 9 (AB9) with UV light was performed, and it was compared with the commercial photocatalyst Degussa P-25, being the best result a total discoloration of dye at 45 min of reaction using the TiO2 photocatalyst undoped synthesized at 2 min. The iron doping did not show an improvement in the photocatalytic activity, and it was also observed that the time of synthesis considerably influences in the photocatalytic activity, with best efficiencies at minor synthesis time.
Terciarización y configuración espacial en México
Authors: Carrillo Arteaga Brian Eric , Cadena Vargas Edel 
Published: October 2019

El proceso de terciarización y el grado en el que impera sobre la configuración espacial del territorio, requieren ser observados considerablemente. En este sentido, mediante el Índice de Especialización Económica (IEE) y diagramas de coordenadas triangulares, aplicados al valor agregado censal bruto, se explora el proceso de terciarización en México por zona metropolitana, identificando a su vez a la zona metropolitana más relevante del proceso. Subsecuentemente, mediante la técnica de análisis de clúster y valor atípico (I Anselin local de Moran), se examinan espacialmente los 12 sectores terciarios del Sistema de Clasificación Industrial de América del Norte (SCIAN), empleando la delimitación por sección electoral, sus estadísticas censales y el Directorio Estadístico Nacional de Unidades Económicas de México (DENUE), para identificar la distribución espacial de las principales aglomeraciones urbanas y el tipo de segregación urbana. Por consiguiente, se logra vislumbrar el campo práctico de la investigación realizada y las ventajas del modelo de análisis expuesto.
Los valores egocéntricos desfavorecen el comportamiento pro-ambiental de los guías de buceo en el Parque Nacional Arrecifes de Cozumel
Authors: Chan Chan Sandra Beatriz , Maynez Guadarrama Aurora , Collantes Chávez-Costa Alejandro Luis , Santander Botello Luis Carlos 
Published: October 2019

El buceo como actividad turística ha potencializado la economía, pero también ha impactado a las zonas arrecifales. Durante el buceo, el guía es el principal actor en la protección del ambiente marino, pues en él recae el control de las actividades realizadas por los buzos. En esta investigación se analiza la relación entre los valores, creencias y normas sobre la intensión que tienen los guías de buceo por conservar el ambiente marino. El estudio se abordó a través de la teoría de Valores, Creencias y Normas (VCN) y fue analizado a través de modelos de ecuaciones estructurales con el método de Partial Least Squares. Se confirma la causalidad del modelo VCN y se identifica que la valoración de los recursos marinos podría estar influenciada por los valores egocéntricos lo cual no permitió la concepción de una intención de un comportamiento que sea favorable.
Tratamiento químico combinado de semilla y su influencia en el crecimiento de plántulas de sorgo, maíz, soya y algodón
Authors: Díaz Franco Arturo , Castillo Tovar Hipólito , Ortiz Chairez Flor Elena , Espinosa Ramírez Martin 
Published: October 2019

El tratamiento químico de semilla es un método alternativo enfocado en la protección y la sanidad de los cultivos, por lo que se considera una práctica eficiente. El objetivo del estudio fue evaluar, en etapa de plántula, el tratamiento de semilla a base de: a) insecticida-fungicida, thiametoxam, fludroxomil y metelaxil-M (Crusier-Maxx®); b) microelementos, Fe (47%) y Zn (62%) (Wolf Trax DDP®); c) combinación de a y b; y d) testigo. Los tratamientos se aplicaron en sorgo (Sorghum bicolor, Norteño), maíz (Zea mays, H-440), soya (Glycine max, Vernal) y algodón (Gossypium hirsutum, FM9250 Trans) en condiciones de riego; en temporal, se aplicaron sorgo y maíz con los mismos híbridos. Los tratamientos no mostraron influencia en la emergencia, densidad de población, clorofila, altura y biomasa de plántulas en los cuatro cultivos ni condición de humedad. La soya manifestó clorosis férrica y no se observó efecto con Fe + Zn. En las condiciones descritas, el tratamiento químico de la semilla no fue efectivo.