bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is known about the LGBTQ perspective in child welfare services? A scoping review protocol
Authors: Kaasbøll Jannike , Paulsen Veronika 
Published: September 2019

IntroductionIn previous studies, it is estimated that sexual minorities (eg, lesbian, gay, bisexual, transgender and questioning (LGBTQ) individuals) are overrepresented in the child welfare system. However, the numbers are unclear, and there are limited studies in this field. No systematic review of LGBTQ issues across a broader context (ie, youth, foster parents and service providers) of child welfare services exists. The overall objective of this scoping review is to systematically scope the existing research on LGBTQ issues in the context of child welfare services, including policy, practice, service providers and users’ perspectives.Methods and analysisThe scoping review framework outlined by the Joanna Briggs Institute (JBI) based on previous work by Arksey and O’Malley and Levac and colleagues will guide this review. In addition, the PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation will be used throughout the process. We will search electronic databases (PubMed, EMBASE, PsycINFO, Web of Science and Idunn) and grey literature sources to identify studies that are appropriate for inclusion in this review. Using inclusion and exclusion criteria based on the ‘Population–Concept–Context’ framework, two researchers will independently screen titles, abstracts and full-text articles considered for inclusion. Any qualitative, quantitative and mixed-method study of LGBTQ issues in the child welfare context will be described and synthesised using a thematic synthesis approach.Ethics and disseminationA scoping review is a secondary analysis of published literature and does not require ethics approval. This scoping review is meant to provide an overview of the existing literature, aiming to expand policy-makers’ and practitioners’ knowledge of LGBTQ issues in a child welfare context and identify research gaps that can be used as a basis for further research. The results will be disseminated through a peer-reviewed publication, a conference presentation and a presentation to the key stakeholders.
Association between hand grip strength and impaired health-related quality of life in Korean cancer survivors: a cross-sectional study
Authors: Paek Jeongki , Choi Yoon Ji 
Published: September 2019

ObjectivesTo assess the association between hand grip strength (HGS) and health-related quality of life (HRQoL) among Korean cancer survivors.DesignPopulation-based cross-sectional study.SettingA nationally representative population survey data (face-to-face interviews and health examinations were performed in mobile examination centres).ParticipantsA total of 1037 cancer survivors (person with cancer of any type who is still living) with available data on HGS and HRQoL in the sixth and seventh Korea National Health and Nutrition Examination Surveys (2014–2017).Primary outcome measuresPrevalence of impaired HRQoL by HGS.ResultsAmong 1037 cancer survivors (60.7% women, mean age=62.2 years), 19.2% of them had weak HGS according to gender-specific cut-off values (lowest quintile<29.7 kg in men and <19.7 kg in women). In the study population, the most common cancer site was the stomach, followed by the thyroid, breast, colorectal and cervix. Individuals with weak HGS showed statistically significantly increased impairment in all five dimensions of the EuroQoL-5 dimension (EQ-5D) compared with those in patients with normal HGS. In a multinomial logistic regression analysis, impaired HRQoL (some or extreme problem in EQ-5D) was significantly reduced in each dimension of the EQ-5D, except for anxiety/depression, when HGS was increased. The OR for impaired HRQoL ranged from 0.86 to 0.97 per 1 kg increase in HGS in four dimensions (mobility, self-care, usual activity and pain/discomfort).ConclusionsWeak HGS was associated with impaired HRQoL in cancer survivors. Future longitudinal studies are needed to confirm the causality between HGS and HRQoL in cancer survivors.
Prevalence and causes of anaemia in children aged 6–23 months in rural Qinghai, China: findings from a cross-sectional study
Authors: Huang Yiwen , Wang Lijuan , Huo Junsheng , Wu Qiong , Wang Wei , Chang Suying , Zhang Yanfeng 
Published: September 2019

ObjectiveTo investigate the current situation of anaemia among children aged 6–23 months in a rural county in China, and to explore the influencing factors and the main causes of anaemia.DesignA cross-sectional study.SettingHuzhu County in Qinghai Province, ChinaParticipantsWe selected 38 sampled villages using Proportional to Population Size sampling method. We obtained the name list of children aged 6–23 months in each sampled village and planned to survey all the eligible children aged 6–23 months and their caregivers.Primary and secondary outcomes measuresThe prevalence of anaemia, the influencing factors of anaemia, the laboratory tests for biological causes of anaemia, including serum ferritin, soluble transferrin receptor, folic acid, homocysteine and vitamin B12.ResultsA total of 754 children aged 6–23 months and their caregivers were surveyed, and 183 anaemic children aged 12–23 months were collected venous blood sample. The anaemia prevalence of children aged 6–23 months in Huzhu County was 59.1%. Children of younger age (OR=0.968, 95% CI 0.940 to 0.998), Tibetan nationality (OR=3.123, 95% CI 1.473 to 6.623) and not introducing meat (OR=0.698, 95% CI 0.499 to 0.976) were more likely to be anaemic. More than 80% of children with anaemia were due to iron deficiency (ID), and 20.2% of them had both iron and folic acid deficiencies.ConclusionsThe anaemia prevalence of children aged 6–23 months in Huzhu County was high and children of younger age, Tibetan nationality and not introducing meat were more likely to be anaemic. The main cause of anaemia was nutritional anaemia, with the vast majority being ID. Interventions of feeding counselling and nutrients supplements are appropriate and should be further strengthened.Trial registration numberChiCTRPRC12002444.
Development and validation of a patient-reported outcome tool to assess cancer-related financial toxicity in Italy: a protocol
Authors: Riva Silvia , Bryce Jane , De Lorenzo Francesco , Del Campo Laura , Di Maio Massimo , Efficace Fabio , Frontini Luciano , Giannarelli Diana , Gitto Lara , Iannelli Elisabetta , Jommi Claudio , Montesarchio Vincenzo , Traclò Francesca , Vaccaro Concetta Maria , Gallo Ciro , Perrone Francesco 
Published: September 2019

IntroductionFinancial toxicity (FT) is a well-recognised problem in oncology. US-based studies have shown that: (a) cancer patients have a 2.7 times risk of bankruptcy; (b) patients who declare bankruptcy have a 79% greater hazard of death; (c) financial burden significantly impairs quality of life (QoL) and (d) reduces compliance and adherence to treatment prescriptions. The aim of the project is to develop and validate a patient-reported-outcome (PRO) measure to assess FT of cancer patients in Italy, where, despite the universal health coverage provided by the National Health Service, FT is an emerging issue.Methods and analysisOur hypothesis is that a specific FT measure, which considers the relevant sociocultural context and healthcare system, would allow us to understand the main determinants of cancer-related FT in Italy, in order to address and reduce these factors. According to the International Society for Pharmaco-economics and Outcomes Research guidelines on PROs, the project will include the following steps: (1) concept elicitation (from focus groups with patients and caregivers; literature; oncologists; nurses) and analysis, creating a coding library; (2) item generation (using a format that includes a question and a response on a 4-point Likert scale) and analysis through patients’ cognitive interviews of item importance within different coding categories to produce the draft instrument; (3) factor analysis and internal validation (with Cronbach’s alpha and test–retest for reliability) to produce the final instrument; (4) external validation with QoL anchors and depression scales. The use of the FT measure in prospective trials is also planned.Ethics and disseminationThe protocol is approved by the ethical committees of all the participating centres. The project will tentatively produce a validated tool by the spring 2021. The project might also represent a model and the basis for future cooperation with other European countries, with different healthcare systems and socioeconomic conditions.Trial registration numberNCT03473379.
Myoclonic epilepsy, parkinsonism, schizophrenia and left-handedness as common neuropsychiatric features in 22q11.2 deletion syndrome
Authors: Fanella Martina , Frascarelli Marianna , Lambiase Caterina , Morano Alessandra , Unolt Marta , Liberati Natascia , Fattouch Jinane , Buzzanca Antonino , Accinni Tommaso , Ceccanti Marco , Viganò Alessandro , Biondi Massimo , Colonnese Claudio , Giallonardo Anna Teresa , Di Fabio Fabio , Pizzuti Antonio , Di Bonaventura Carlo , Berardelli Alfredo 
Published: September 2019

Background22q11.2 deletion syndrome (22q11.2DS) is considered as the genetic model of schizophrenia. However, its polymorphic nature has led researchers to further investigate its neuropsychiatric manifestations.MethodsWe enrolled 56 adults (38 men, 18 women) diagnosed with 22q11.2DS. All subjects were evaluated by a multidisciplinary team. The neuropsychiatric features were investigated by means of clinical and neurophysiological evaluation (video-EEG).ResultsThirty per cent of our patients were left-handed. Fifty-eight per cent had a low IQ, and 22 of 56 subjects had psychotic disorders (13 of 22 with schizophrenia). Eighteen patients reported at least one seizure in their lifetime, and ten were diagnosed with epilepsy; among them, seven had genetic generalised epilepsy (GGE), and five of seven showed features suggestive of juvenile myoclonic epilepsy (JME). Video-EEG recordings revealed generalised epileptiform abnormalities in 24 of 56 cases. Besides, only one patient with epilepsy had a cardiac malformation. Lastly, 31 of 56 subjects presented with parkinsonism, 16 of whom were taking neuroleptics. None of the 15 patients with parkinsonism not related to neuroleptic therapy was diagnosed with epilepsy, compared with 6 of those taking antipsychotics.Conclusions22q11.2DS is characterised by left-handedness and neuropsychiatric features such as cognitive impairment, schizophrenia, epilepsy and parkinsonism. GGE, mostly the JME phenotype, is the predominant epilepsy type. The significant association between 22q11.2DS and parkinsonian features confirms these patients’ genetic susceptibility to parkinsonism. Despite the lack of any conclusive evidence, our study suggests a possible relationship between the analysed clinical variables: (1) an inverse correlation between low IQ/psychosis/epilepsy and major cardiac diseases; (2) a direct association between psychosis and both mental delay and epilepsy; and (3) an inverse correlation between parkinsonism and epilepsy.
Fault fictions: systematic biases in the conceptualization of fault-zone architecture
Authors: Shipton Z. K. , Roberts J. J. , Comrie E. L. , Kremer Y. , Lunn R. J. , Caine J. S. 
Published: September 2019

Abstract
Mental models are a human's internal representation of the real world and have an important role in the way we understand and reason about uncertainties, explore potential options and make decisions. Mental models have not yet received much attention in geosciences, yet systematic biases can affect any geological investigation: from how the problem is conceived, through selection of appropriate hypotheses and data collection/processing methods, to the conceptualization and communication of results. We draw on findings from cognitive science and system dynamics, with knowledge and experiences of field geology, to consider the limitations and biases presented by mental models in geoscience, and their effect on predictions of the physical properties of faults in particular. We highlight biases specific to geological investigations and propose strategies for debiasing. Doing so will enhance how multiple data sources can be brought together, and minimize controllable geological uncertainty to develop more robust geological models. Critically, there is a need for standardized procedures that guard against biases, permitting data from multiple studies to be combined and communication of assumptions to be made. While we use faults to illustrate potential biases in mental models and the implications of these biases, our findings can be applied across the geosciences.
Take a Look Around
Authors: Law Stephen , Paige Brooks , Russell Chris 
Published: September 2019

When an individual purchases a home, they simultaneously purchase its structural features, its accessibility to work, and the neighborhood amenities. Some amenities, such as air quality, are measurable while others, such as the prestige or the visual impression of a neighborhood, are difficult to quantify. Despite the well-known impacts intangible housing features have on house prices, limited attention has been given to systematically quantifying these difficult to measure amenities. Two issues have led to this neglect. Not only do few quantitative methods exist that can measure the urban environment, but that the collection of such data is both costly and subjective.
We show that street image and satellite image data can capture these urban qualities and improve the estimation of house prices. We propose a pipeline that uses a deep neural network model to automatically extract visual features from images to estimate house prices in London, UK. We make use of traditional housing features such as age, size, and accessibility as well as visual features from Google Street View images and Bing aerial images in estimating the house price model. We find encouraging results where learning to characterize the urban quality of a neighborhood improves house price prediction, even when generalizing to previously unseen London boroughs.

We explore the use of non-linear vs. linear methods to fuse these cues with conventional models of house pricing, and show how the
interpretability
of linear models allows us to directly extract proxy variables for visual desirability of neighborhoods that are both of interest in their own right, and could be used as inputs to other econometric methods. This is particularly valuable as once the network has been trained with the training data, it can be applied elsewhere, allowing us to generate vivid dense maps of the visual appeal of London streets.
MilliBack
Authors: Xiao Ning , Yang Panlong , Li Xiang-Yang , Zhang Yanyong , Yan Yubo , Zhou Hao 
Published: September 2019

Real-time handwriting tracking is important for many emerging applications such as Artificial Intelligence assisted education and healthcare. Existing movement tracking systems, including those based on vision, ultrasound or wireless technologies, fail to offer high tracking accuracy, no learning/training/calibration process, low tracking latency, low cost and easy to deploy at the same time. In this work, we design and evaluate a wireless backscattering based handwriting tracking system, called MilliBack, that satisfies all these requirements. At the heart of MilliBack are two Phase Differential Iterative (PDI) schemes that can infer the position of the backscatter tag (which is attached to a writing tool) from the change in the signal phase. By adopting carefully-designed differential techniques in an iterative manner, we can take the diversity of devices out of the equation. The resulting position calculation has a linear complexity with the number of samples, ensuring fast and accurate tracking.
We have put together a MilliBack prototype and conducted comprehensive experiments. We show that our system can track various handwriting traces accurately, in some testings it achieve a median error of 4.9 mm. We can accurately track and reconstruct arbitrary writing/drawing trajectories such as equations, Chinese characters or just random shapes. We also show that MilliBack can support relatively high writing speed and smoothly adapt to the changes of working environment.
FarSense
Authors: Zeng Youwei , Wu Dan , Xiong Jie , Yi Enze , Gao Ruiyang , Zhang Daqing 
Published: September 2019

The past few years have witnessed the great potential of exploiting channel state information retrieved from commodity WiFi devices for respiration monitoring. However, existing approaches only work when the target is close to the WiFi transceivers and the performance degrades significantly when the target is far away. On the other hand, most home environments only have one WiFi access point and it may not be located in the same room as the target. This sensing range constraint greatly limits the application of the proposed approaches in real life.This paper presents FarSense--the first real-time system that can reliably monitor human respiration when the target is far away from the WiFi transceiver pair. FarSense works well even when one of the transceivers is located in another room, moving a big step towards real-life deployment. We propose two novel schemes to achieve this goal: (1) Instead of applying the raw CSI readings of individual antenna for sensing, we employ the ratio of CSI readings from two antennas, whose noise is mostly canceled out by the division operation to significantly increase the sensing range; (2) The division operation further enables us to utilize the phase information which is not usable with one single antenna for sensing. The orthogonal amplitude and phase are elaborately combined to address the "blind spots" issue and further increase the sensing range. Extensive experiments show that FarSense is able to accurately monitor human respiration even when the target is 8 meters away from the transceiver pair, increasing the sensing range by more than 100%.1 We believe this is the first system to enable through-wall respiration sensing with commodity WiFi devices and the proposed method could also benefit other sensing applications.
Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance
Authors: Pelullo Maria , Nardozza Francesca , Zema Sabrina , Quaranta Roberta , Nicoletti Carmine , Besharat Zein Mersini , Felli Maria Pia , Cerbelli Bruna , d'Amati Giulia , Palermo Rocco , Capalbo Carlo , Talora Claudio , Di Marcotullio Lucia , Giannini Giuseppe , Checquolo Saula , Screpanti Isabella , Bellavia Diana 
Published: September 2019

Abstract

Colorectal cancer is characterized by well-known genetic defects and approximately 50% of cases harbor oncogenic Ras mutations. Increased expression of Notch ligand Jagged1 occurs in several human malignancies, including colorectal cancer, and correlates with cancer progression, poor prognosis, and recurrence. Herein, we demonstrated that Jagged1 was constitutively processed in colorectal cancer tumors with mutant Kras, which ultimately triggered intrinsic reverse signaling via its nuclear-targeted intracellular domain Jag1-ICD. This process occurred when Kras/Erk/ADAM17 signaling was switched on, demonstrating that Jagged1 is a novel target of the Kras signaling pathway. Notably, Jag1-ICD promoted tumor growth and epithelial–mesenchymal transition, enhancing colorectal cancer progression and chemoresistance both in vitro and in vivo. These data highlight a novel role for Jagged1 in colorectal cancer tumor biology that may go beyond its effect on canonical Notch activation and suggest that Jag1-ICD may behave as an oncogenic driver that is able to sustain tumor pathogenesis and to confer chemoresistance through a noncanonical mechanism.

Significance:
These findings present a novel role of the transcriptionally active Jag1-ICD fragment to confer and mediate some of the activity of oncogenic KRAS.
Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study
Authors: Morgensztern Daniel , Besse Benjamin , Greillier Laurent , Santana-Davila Rafael , Ready Neal , Hann Christine L. , Glisson Bonnie S. , Farago Anna F. , Dowlati Afshin , Rudin Charles M. , Le Moulec Sylvestre , Lally Satwant , Yalamanchili Sreeni , Wolf Jürgen , Govindan Ramaswamy , Carbone David P. 
Published: September 2019

Abstract

Purpose:
Although extensive-stage small-cell lung cancer (SCLC) is highly responsive to first-line therapy, virtually all patients develop resistance with short survival. Rovalpituzumab tesirine (Rova-T) is an antibody–drug conjugate targeting delta-like 3 protein (DLL3). This open-label, single-arm, phase II study (TRINITY) assessed safety and efficacy of Rova-T in patients with DLL3-expressing SCLC in the third-line and beyond (3L+) setting.

Patients and Methods:
Patients with DLL3-expressing SCLC (determined by mouse antibody immunohistochemistry [IHC] assay), and ≥2 prior regimens, received 0.3 mg/kg Rova-T once every 6 weeks for two cycles. During study, a rabbit antibody IHC assay was developed and used for the final analysis, with DLL3-positive and DLL3-high defined as ≥25% and ≥75% of tumor cells positive for DLL3, respectively. The primary endpoints were objective response rate (ORR) and overall survival (OS).

Results:
Among 339 patients enrolled, 261 (77%) had two prior lines of therapy and 78 (23%) had ≥3. DLL3-high and DLL3-positive tumors by rabbit IHC were seen in 238 (70%) and 287 (85%) patients, respectively. The remaining 52 (15%) were DLL3-negative only by rabbit IHC or had missing results. ORR was 12.4%, 14.3%, and 13.2% in all, DLL3-high, and DLL3-positive patients, respectively. Median OS was 5.6 months in all patients and 5.7 months in DLL3-high patients. The most common adverse events (AE) were fatigue, photosensitivity reaction, and pleural effusion. Grade 3–5 AEs were seen in 213 (63%) patients.

Conclusions:
Rova-T is the first targeted agent in SCLC to use DLL3, a novel biomarker. However, results demonstrate modest clinical activity in 3L+ SCLC, with associated toxicities.
Os essencialismos de gênero pelo viés da ironia
Authors: Moreira Thaís Batista Rosa 
Published: September 2019

O começo do século XX, permeado por diversos movimentos políticos no contexto brasileiro, bem como internacional, foi um momento chave para a articulação das pautas feministas de emancipação e reivindicação de direitos. No Brasil, a questão ganhou evidência principalmente após a proposta de emenda constitucional favorável ao sufrágio em 1917, além da criação da Federação Brasileira pelo Progresso Feminino em 1922. Ações como essas despertaram diversos posicionamentos contrários na opinião pública, que se utilizou de diferentes linguagens para deslegitimar as demandas feministas. A proposta desse artigo é analisar manejos de ideias essencialistas de gênero para defender posicionamentos antifeministas e antissufragistas em publicações especificamente veiculadas entre 1919 e 1931 em revistas ilustradas humorísticas de grande tiragem na cidade do Rio de Janeiro. Dentre caricaturas e anedotas, algumas edições das revistas O Malho e Careta trouxeram o tema do emancipação feminina e do sufrágio de forma satírica ao público leitor. Propomos a hipótese de que esse setor da imprensa, em especial, teve papel de destaque como porta-voz das críticas ao movimento sufragista-feminista. Para isso, traçamos uma reflexão sobre como operaram os discursos humorísticos e seus propósitos como linguagem para criticar as(os) militantes dos direitos políticos para mulheres no período em questão.