bluuebunny/crossref_metadata_2025_split huggingface dataset:
White‐Light Emission from a Semi‐Conductive Borate‐Stannate
Authors: Lin Yuan , Wang Guan‐E , Hu Chun‐Li , Feng Jiang‐He , Li Li‐Na , Mao Jiang‐Gao 
Published: July 2019

AbstractIn response to ever‐increasing application requirements in lighting and displays, a tremendous emphasis is being placed on single‐component white‐light emission. Single‐component inorganic borates doped with rare earth metal ions have shown prominent achievements in white‐light emission. The first environmentally friendly defect‐induced white‐light emitting crystalline inorganic borate, Ba2[Sn(OH)6][B(OH)4]2, has been prepared. Additionally, it is the first borate‐stannate without a Sn−O−B linkage. Notably, Ba2[Sn(OH)6][B(OH)4]2 shows Commission Internationale de l'Eclairage (CIE) chromaticity coordinates of (0.42, 0.38), an ultrahigh color rendering index (CRI) of 94.1, and an appropriate correlated color temperature (CCT) of 3083 K. Such a promising material will provide a new approach in the development of white‐light emitting applications.
Periodic Melting of Oligonucleotides by Oscillating Salt Concentrations Triggered by Microscale Water Cycles Inside Heated Rock Pores
Authors: Ianeselli Alan , Mast Christof B. , Braun Dieter 
Published: July 2019

AbstractTo understand the emergence of life, a better understanding of the physical chemistry of primordial non‐equilibrium conditions is essential. Significant salt concentrations are required for the catalytic function of RNA. The separation of oligonucleotides into single strands is a difficult problem as the hydrolysis of RNA becomes a limiting factor at high temperatures. Salt concentrations modulate the melting of DNA or RNA, and its periodic modulation would enable melting and annealing cycles at low temperatures. In our experiments, a moderate temperature difference created a miniaturized water cycle, resulting in fluctuations in salt concentration, leading to melting of oligonucleotides at temperatures 20 °C below the melting temperature. This would enable the reshuffling of duplex oligonucleotides, necessary for ligation chain replication. The findings suggest an autonomous route to overcome the strand‐separation problem of non‐enzymatic replication in early evolution.
Basic [Au25(SCH2CH2Py)18]−⋅Na+ Clusters: Synthesis, Layered Crystallographic Arrangement, and Unique Surface Protonation
Authors: Huang Zhong , Ishida Yohei , Yonezawa Tetsu 
Published: July 2019

AbstractThe synthesis of high‐purity and high‐yield Au25 clusters protected by the basic pyridyl ethanethiol (HSCH2CH2Py, 4‐PyET and 2‐PyET) is presented. Single‐crystal X‐ray diffraction of the [Au25(4‐PyET)18]−⋅Na+ clusters has revealed a structure similar to that known for the phenyl ethanethiolate analogue, but with pyridyl‐N coordination to Na+, a more relaxed ligand shell, and a profoundly layered arrangement in the solid state. Because of the pendant Py moiety, the [Au25(PyET)18]− clusters are endowed with unique (de)protonation equilibria, which has been characterized in detail by UV/Vis absorption and 1H NMR spectroscopy. [Au25(PyET)18]− clusters showed an unexpectedly H+‐dependent solubility that is tunable in aqueous and organic solvents. The successful synthesis of the basic Py‐terminated thiolate‐protected Au25 clusters paves the way to realize a new family of metalloid clusters possessing basic properties.
Cover Image, Volume 13, Issue 4
Authors: Nugroho Yohanes K. , Zhu Liandong 
Published: July 2019

The cover image by is based on the Modeling and Analysis An integration of algal biofuel production planning, scheduling, and order‐based inventory distribution control systems by Yohanes K. Nugroho and Liandong Zhu, DOI: 10.1002/bbb.1982.
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Survival of infants with spina bifida and the role of maternal prepregnancy body mass index
Authors: Pace Nelson D. , Siega‐Riz Anna Maria , Olshan Andrew F. , Chescheir Nancy C. , Cole Stephen R. , Desrosiers Tania A. , Tinker Sarah C. , Hoyt Adrienne T. , Canfield Mark A. , Carmichael Suzan L. , Meyer Robert E. ,   The National Birth Defects Prevention Study
Published: July 2019

AbstractObjectiveTo investigate first‐year survival of infants born with spina bifida, and examine the association of maternal prepregnancy body mass index (BMI) with infant mortality.MethodsThis is a retrospective cohort study of 1,533 liveborn infants with nonsyndromic spina bifida with estimated dates of delivery from 1998 to 2011 whose mothers were eligible for the National Birth Defects Prevention Study (NBDPS). NBDPS data were linked to death records to conduct survival analyses. Kaplan–Meier survival functions estimated mortality risk over the first year of life. Cox proportional hazards models estimated hazard ratios (HRs) for maternal prepregnancy BMI categorized as underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).ResultsInfant mortality risk among infants with spina bifida was (4.4% [3.52, 5.60%]). Infants with multiple co‐occurring defects, very preterm delivery, multiple gestation, high‐level spina bifida lesions, or non‐Hispanic Black mothers had an elevated risk of infant mortality. Maternal prepregnancy underweight and obesity were associated with higher infant mortality (15.7% [7.20, 32.30%] and 5.82% [3.60, 9.35%], respectively). Adjusted HR estimates showed underweight and obese mothers had greater hazard of infant mortality compared to normal weight mothers (HR: 4.5 [1.08, 16.72] and 2.6 [1.36, 8.02], respectively).ConclusionThe overall risk of infant mortality for infants born with spina bifida was lower than most previously reported estimates. Infants born with spina bifida to mothers who were underweight or obese prepregnancy were at higher risk of infant mortality. This study provides additional evidence of the importance of healthy maternal weight prior to pregnancy.
A replication of the response‐restriction preference assessment
Authors: Boyle Megan A. , Curtis Kaitlin S. , Forck Kara L. , Fudge Brittany M. , Speake Heather N. , Pauls Benjamin P. 
Published: July 2019

AbstractWe replicated the response‐restriction (RR) preference assessment and compared results in terms of preference hierarchies to those from free‐operant and multiple stimulus without replacement (MSWO) formats with six children with autism spectrum disorders (ASDs). We also assessed social validity of each format with teachers and clinicians who work with children with ASDs. Complete hierarchies were produced in four of 18 assessments and with MSWO and RR formats only. Results of the social validity assessment varied across raters, with each preference assessment format receiving the highest rating from at least one rater. Results are discussed in terms of practical recommendations and relative to the preference assessment literature as a whole.
Mycoplasma hyorhinis infection promotes gastric cancer cell motility via β‐catenin signaling
Authors: Liu Xia , Rong Zhuona , Shou Chengchao 
Published: July 2019

AbstractBackgroundWe previously identified that Mycoplasma hyorhinis infection promotes gastric cancer cell motility. The β‐catenin signaling pathway is critical to determining malignant cancer cell phenotypes; however, the association between M hyorhinis and the β‐catenin signaling pathway is unclear.MethodsWe performed subcellular fractionation and immunofluorescence staining to observe β‐catenin accumulation in the nucleus. The expression of downstream β‐catenin genes was detected by quantitative RT‐PCR. Gastric cancer cell motility was examined by transwell chamber migration and wound healing assays, and a co‐immunoprecipitation assay was used to detect the proteins associated with the membrane protein p37 of M hyorhinis.ResultsWe found that M hyorhinis infection promoted nuclear β‐catenin accumulation and enhanced the expression of downstream β‐catenin genes. M hyorhinis‐promoted gastric cancer cell motility was counteracted by treatment with the β‐catenin inhibitor XAV939 or β‐catenin knockdown. We further detected a protein complex containing LRP6, GSK3β, and p37 in M hyorhinis‐infected cells. M hyorhinis also induced LRP6 phosphorylation in a GSK3β‐dependent fashion. Knockdown of LRP6 or GSK3β abolished M hyorhinis‐induced cell motility.ConclusionOur results reveal that the β‐catenin signaling pathway could be activated by M hyorhinis infection, thereby contributing to M hyorhinis‐induced gastric cancer cell motility.
A favorable inductive remission rate for decitabine combined with chemotherapy as a first course in <60‐year‐old acute myeloid leukemia patients with myelodysplasia syndrome features
Authors: Liu Fengqi , Wang Hehua , Liu Junru , Zhou Zhenhai , Zheng Dong , Huang Beihui , Su Chang , Zou Waiyi , Xu Duorong , Tong Xiuzhen , Li Juan 
Published: July 2019

AbstractIn acute myeloid leukemia (AML), myelodysplasia‐related changes contribute to a poor prognosis. This retrospective, propensity score‐matched study analyzed 108 newly diagnosed AML patients with features of myelodysplasia syndrome (MDS) (aged 14‐60 years) from 2014 to 2018, who received either idarubicin and cytarabine (IA) or decitabine, idarubicin and cytarabine (DAC+IA), and compared efficacy and toxicity between the two regimens. After propensity score matching, there were 54 patients in each group. The rate of complete remission (CR) was higher in the DAC+IA group than in the IA group (85.2% vs 68.5%, P = .040) after the first course, and toxicities were comparable in both groups. Multivariate analysis indicated that the combination with DAC was independent factor for CR rate after the first induction therapy (OR = 2.978, 95% CI:1.090‐8.137, P = .033). Subgroup analysis showed a CR advantage for DAC+IA (vs IA) for patients of intermediate‐high risk status according to National Comprehensive Cancer Network prognostic stratification. In conclusion, DAC+IA is therefore offered as a new induction choice for newly diagnosed AML patients with features of MDS, aged <60 years old, especially in intermediate‐high risk status.
A π‐Conjugated, Covalent Phosphinine Framework
Authors: Huang Jieyang , Tarábek Ján , Kulkarni Ranjit , Wang Cui , Dračínský Martin , Smales Glen J. , Tian Yu , Ren Shijie , Pauw Brian R. , Resch‐Genger Ute , Bojdys Michael J. 
Published: July 2019

AbstractStructural modularity of polymer frameworks is a key advantage of covalent organic polymers, however, only C, N, O, Si, and S have found their way into their building blocks so far. Here, the toolbox available to polymer and materials chemists is expanded by one additional nonmetal, phosphorus. Starting with a building block that contains a λ5‐phosphinine (C5P) moiety, a number of polymerization protocols are evaluated, finally obtaining a π‐conjugated, covalent phosphinine‐based framework (CPF‐1) through Suzuki–Miyaura coupling. CPF‐1 is a weakly porous polymer glass (72.4 m2 g−1 BET at 77 K) with green fluorescence (λmax=546 nm) and extremely high thermal stability. The polymer catalyzes hydrogen evolution from water under UV and visible light irradiation without the need for additional co‐catalyst at a rate of 33.3 μmol h−1 g−1. These results demonstrate for the first time the incorporation of the phosphinine motif into a complex polymer framework. Phosphinine‐based frameworks show promising electronic and optical properties, which might spark future interest in their applications in light‐emitting devices and heterogeneous catalysis.
Design of a Highly Active Pd Catalyst with P,N Hemilabile Ligands for Alkoxycarbonylation of Alkynes and Allenes: A Density Functional Theory Study
Authors: Ahmad Shahbaz , Bühl Michael 
Published: July 2019

AbstractIn the palladium‐catalysed methoxycarbonylation of technical propyne, the presence of propadiene poisons the hemilabile Pd(P,N) catalyst. According to density functional theory calculations (B3PW91‐D3/PCM level), a highly stable π‐allyl intermediate is the reason for this catalyst poisoning. Predicted regioselectivities suggest that at least 11 % of propadiene should yield this allyl intermediate, in which the reaction gets stalled under the turnover conditions due to an insurmountable methanolysis barrier of 25.8 kcal mol−1. The results obtained for different ligands and substrates are consistent with the available experimental data. A new ligand, (6‐Cl‐3‐Me‐Py)PPh2, is proposed, which is predicted to efficiently control the branched/linear selectivity, avoiding rapid poisoning (with only 0.2 % of propadiene being trapped as the Pd allyl complex), and to tremendously increase the catalytic activity by decreasing the overall barrier to 9.1 kcal mol−1.
The Effect of Branching on the One‐ and Two‐Photon Absorption, Cell Viability, and Localization of Cationic Triarylborane Chromophores with Dipolar versus Octupolar Charge Distributions for Cellular Imaging
Authors: Griesbeck Stefanie , Michail Evripidis , Rauch Florian , Ogasawara Hiroaki , Wang Chenguang , Sato Yoshikatsu , Edkins Robert M. , Zhang Zuolun , Taki Masayasu , Lambert Christoph , Yamaguchi Shigehiro , Marder Todd B. 
Published: July 2019

AbstractTwo different chromophores, namely a dipolar and an octupolar system, were prepared and their linear and nonlinear optical properties as well as their bioimaging capabilities were compared. Both contain triphenylamine as the donor and a triarylborane as the acceptor, the latter modified with cationic trimethylammonio groups to provide solubility in aqueous media. The octupolar system exhibits a much higher two‐photon brightness, and also better cell viability and enhanced selectivity for lysosomes compared with the dipolar chromophore. Furthermore, both dyes were applied in two‐photon excited fluorescence (TPEF) live‐cell imaging.
A Molecular Tool Targeting the Base‐Flipping Activity of Human UHRF1
Authors: Zaayter Liliyana , Mori Mattia , Ahmad Tanveer , Ashraf Waseem , Boudier Christian , Kilin Vasyl , Gavvala Krishna , Richert Ludovic , Eiler Sylvia , Ruff Marc , Botta Maurizio , Bronner Christian , Mousli Marc , Mély Yves 
Published: July 2019

AbstractDuring DNA replication, ubiquitin‐like, containing PHD and RING fingers domains 1 (UHRF1) plays key roles in the inheritance of methylation patterns to daughter strands by recognizing through its SET and RING‐associated domain (SRA) the methylated CpGs and recruiting DNA methyltransferase 1 (DNMT1). Herein, our goal is to identify UHRF1 inhibitors targeting the 5′‐methylcytosine (5mC) binding pocket of the SRA domain to prevent the recognition and flipping of 5mC and determine the molecular and cellular consequences of this inhibition. For this, we used a multidisciplinary strategy combining virtual screening and molecular modeling with biophysical assays in solution and cells. We identified an anthraquinone compound able to bind to the 5mC binding pocket and inhibit the base‐flipping process in the low micromolar range. We also showed in cells that this hit impaired the UHRF1/DNMT1 interaction and decreased the overall methylation of DNA, highlighting the critical role of base flipping for DNMT1 recruitment and providing the first proof of concept of the druggability of the 5mC binding pocket. The selected anthraquinone appears thus as a key tool to investigate the role of UHRF1 in the inheritance of methylation patterns, as well as a starting point for hit‐to‐lead optimizations.
Biomimetic Extreme‐Temperature‐ and Environment‐Adaptable Hydrogels
Authors: Zhou Dan , Chen Fan , Handschuh‐Wang Stephan , Gan Tiansheng , Zhou Xiaohu , Zhou Xuechang 
Published: July 2019

AbstractRecently, temperature‐resistant hydrogels, hydrogels which are freezing‐ and dehydration‐resistant, have garnered considerable attention in the scientific community as they extend the rage of application of hydrogels to arid and/or cold environments. Besides, these hydrogels exhibit tunable conductivity and mechanical performance while offering excellent biocompatibility and flexibility, making them interesting candidates for flexible and wearable electronics and (bio)sensors. Several biomimetic strategies were developed to fabricate anti‐freezing and anti‐dehydration hydrogels with a diversity of merits, such as high strain resistance and conductivity, even at sub‐zero temperatures, and employed as (bio)sensors, electrodes, and energy‐storage devices. This review summarizes the recent advances in the preparation and application of temperature‐resistant hydrogels, indicates issues of the state‐of‐the‐art hydrogels, and offers potential future research directions.
Genome‐Wide Measurement and Computational Analysis of Transcription Factor Binding and Chromatin Accessibility in Lymphocytes
Authors: Sadiyah M. Firas , Roychoudhuri Rahul 
Published: July 2019

AbstractCells of the adaptive immune system, including CD4+ and CD8+ T cells, as well as B cells, possess the ability to undergo dynamic changes in population size, differentiation state, and function to counteract diverse and temporally stochastic threats from the external environment. To achieve this, lymphocytes must be able to rapidly control their gene‐expression programs in a cell‐type‐specific manner and in response to extrinsic signals. Such capacity is provided by transcription factors (TFs), which bind to the available repertoire of regulatory DNA elements in distinct lymphocyte subsets to program cell‐type‐specific gene expression. Here we provide a set of protocols that utilize massively parallel sequencing–based approaches to map genome‐wide TF‐binding sites and accessible chromatin, with consideration of the unique aspects and technical issues facing their application to lymphocytes. We show how to computationally validate and analyze aligned data to map differentially enriched/accessible sites, identify enriched DNA sequence motifs, and detect the position of nucleosomes adjacent to accessible DNA elements. These techniques, when applied to immune cells, can enhance our understanding of how gene‐expression programs are controlled within lymphocytes to coordinate immune function in homeostasis and disease. © 2019 by John Wiley & Sons, Inc.
Alkaline electrochemical leaching of Sn and Pb from the surface of waste printed circuit board and the stripping of gold by methanesulfonic acid
Authors: Zhang Xiaojiao , Zhang Chenglong , Zheng Feilong , Ma En , Wang Ruixue , Bai Jianfeng , Yuan Wenyi , Wang Jingwei 
Published: July 2019

ABSTRACTThe variety of metals and organic in the waste printed circuit board (PCB) that makes them harmful to environment but also contain high economic value. The precious metals of gold on the surface of waste PCB has a high recovery value. In this article, a cleaner hydrometallurgical process for production of Sn, Pb, and Au from the surface of waste PCB was developed. With the alkaline electrochemical leaching, 100% of Sn and Pb in the solder can be extracted at NaOH concentration of 3 mol/L, current density of 300A/m2, and temperature over 8°C after electrochemical leaching of 120 min, and the components can be removed simultaneously. With the technique of methane sulfonic acid etching, the copper and nickel undered the gold plate were leached and then the gold foil can be collected. The optimum conditions of methane sulfonic acid etching technique was explored: under the room temperature, with the solid‐liquid ratio of 1:5, the amount of the hydrogen peroxide is 20%, and the volume fraction of methane sulfonic acid is 15%, the soaking time of the phone board is 150 min (the coating flaking time varied slightly due to the type difference of plates), the recovering rate of gold may be up to 95%. In addition, the method has a good selectivity for element Au, the stripped gold can be melted directly, while the treated waste PCB can be used for other metal or nonmetal recovering, the solution can also be recycled after recovering copper and nickel.
Reproductive justice and support for young fathers
Authors: Dukes Andre , Palm Glen 
Published: July 2019

ABSTRACTThe current article addresses the interests and contributions of fathers to child development and well‐being within a reproductive and social justice framework. We present an overview of research on the role of fathers in the lives of children from the prenatal period through early childhood, with an emphasis on fathers as partners and caregivers in promoting the reproductive health and safety of women and the healthy development of young children. We explore especially the challenges of young, at‐risk fathers as well as system and practice opportunities that support their contributions as partners and parents. Our goal of the article is to extend the discourse on reproductive and social justice to include the shared responsibility of all parents and facilitate circumstances whereby children experience the support needed to become nurturing caregivers for the next generation.
Reconceiving the field: Infant mental health, intersectionality, and reproductive justice
Authors: St. John Maria Seymour 
Published: July 2019

ABSTRACTThe field of infant mental health is conventionally comprised of professional discourses including developmental science, psychology, and psychiatry, among others, and involves spheres of practice as wide‐ranging as pediatrics, maternal/child health, early intervention, early care and education, and child welfare. The World Association of Infant Mental Health [WAIMH] put out its position paper on the rights of infants in 2014 (amended in March 2016) in recognition of the human rights implications of professional understanding of infants’ unique, yet universal, developmental capacities and needs. This article links the policy issues outlined in the WAIMH position paper with critical issues in the field of reproductive justice, extending the reach of WAIMH's call to action on behalf of infants’ rights, and pointing the way toward potent alliances among interconnected movements. Connecting the dots among economic injustice, race‐based health disparities, and gender inequities, the article demonstrates that it is not possible to safeguard infant mental health unless we make reproductive justice a reality.
Triptolide‐induced hepatotoxicity via apoptosis and autophagy in zebrafish
Authors: Huo Jingting , Yu Qinwei , Zhang Yun , Liu Kechun , Hsiao Chung‐Der , Jiang Zhenzhou , Zhang Luyong 
Published: July 2019

AbstractPrevious research about the development of triptolide (TP) as a natural active compound has often focused on hepatotoxicity. Among its various mechanisms, autophagy and apoptosis are two important signaling pathways. In this study, we used zebrafish to establish a TP‐induced hepatotoxicity model, and investigated the roles of autophagy and apoptosis in the progress of liver injury. Zebrafish exposed to TP showed increased mortality and malformation because of the increased drug dose and duration of exposure. Meanwhile, we found that TP induced liver injury in a time‐ and dose‐dependent manner, which was observed as a reduction in liver area, slow yolk absorption, upregulation of transaminase and local neurosis. With the application of the high‐content imaging system (HCIS) technique in liver 3D imaging in vivo, clear imaging of the zebrafish liver was achieved. The results showed a decrease in volume and location of necrosis in the liver after TP exposure. Increased expression of inflammatory cytokines genes tumor necrosis factor (Tnf)α, Il1β and Il6 were shown, particularly Tnfα. The Fas‐Caspase8 signaling pathway was activated. The apoptosis‐related gene Bcl‐2 was increased, and Bax, Caspase9 and Caspase3 were increased. However, autophagy related genes Beclin1, Atg5, Atg3 and Lc3 were increased more significantly, and the changes of Beclin1 and Atg5 were the most severe. This study successfully established a TP‐induced zebrafish hepatotoxicity model and applied the HCIS technique in a zebrafish hepatotoxicity study. The result indicated Fas might be the main target of TP‐induced hepatotoxicity. Autophagy played a more important role than apoptosis and was characterized by the overexpression of Beclin1 and Atg5.