bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corona crisis disruptions and consequences for demand for freight transport: A screening of the effects for the largest logistics service providers in Norway
Authors: Hovi Inger Beate , Pinchasik Daniel Ruben 
Published: November 2024

AbstractThe present article investigates corona crisis disruptions and consequences for freight transport demand, using shipment data from major logistic service providers in Norway, as well as interviews. We investigate how Covid-19 affected demand for freight transport and transport volumes in different segments, changes for parcel delivery, home-deliveries, which industries were most affected and discussed main issues for LSPs in maintaining robust transport chains. We find temporary reductions in B2B deliveries after the first Norwegian societal lockdown but large volume increases in B2C deliveries, which remained at higher levels and saw further waves of increases. Especially home deliveries and mailbox deliveries of parcels increased, particularly in relation with new infection waves. At an aggregate level, retail trade experienced by far the largest volume increases, followed by transport and storage. The latter can in part be due to increasing low-volume import (parcels) from abroad being attributed to e.g. warehouses or customs. At the other end of the scale, wholesale trade stands out with the largest tonnage decrease, followed by manufacturing.
Biogenic synthesis of silver nanoparticles from Hylocereus undatus peel waste: exploring EGFR inhibition for targeted therapy of cervical and breast carcinomas
Authors: Reddy Kushala , Salve Preeti 
Published: November 2024

Abstract
Background
Cancer is one of the leading causes of death worldwide, with breast and cervical cancers being the most common among women. Over 100,000 new cases of breast cancer and 510,000 new cases of cervical cancer are diagnosed annually. This study aimed to develop and evaluate an eco-friendly, low-cost method to synthesize silver nanoparticles using Hylocereus undatus (dragon fruit) peel extract for their anticancer activity.

Results
Silver nanoparticles loaded with Hylocereus undatus fruit peel extract were successfully developed by a green synthesis technique and were optimized by UV–vis spectroscopy. The nanoparticles had an average size of 71.66 nm, a polydispersity index of 0.3754, and a zeta potential of − 38.52, with a spherical shape and 79.5% silver content. Their maximum absorbance was at 448 nm. Further, in vitro anticancer activity via MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay was evaluated and the synthesized nanoparticles displayed IC50 values at 23.51 µg/ml and 23.66 µg/ml against Hela and MDA MB 231 cell lines, respectively. Cytocompatibility studies showed high cell viability (≥ 95%) in L929 mouse fibroblast cells, indicating low toxicity. In silico analyses, including network pharmacology and molecular docking, identified kaempferol and quercetin as key anticancer compounds, with epidermal growth factor receptor (EGFR) (PDB ID: IM17) being the most significant protein target. Docking studies performed by using the Glide module of Schrodinger’s software displayed that kaempferol and quercetin had higher binding affinities for EGFR as compared to the standard drug erlotinib, with MET 769 being a crucial binding site.

Conclusion
Thus, the outcomes suggest that synthesized silver nanoparticles loaded with Hylocereus undatus fruit peel extract could be a potential and promising drug carrier aiding in cancer treatment.
Evaluation of factors associated with the temporomandibular joint dysfunction in university students
Authors: Altın Fatma Nur , Aslan Telci Emine , Özden Fatih 
Published: November 2024

Abstract
Background
Temporomandibular joint dysfunction (TMD) is a multifactorial and complex problem. The underlying causes of the symptoms and related factors of TMD should be specifically identified. This study aimed to examine factors in the relationship between TMD severity and compare cases regarding TMD severity in university students.

Methods
The participants were evaluated with the Visual Analog Scale (VAS) for jaw and neck pain severity. TMD severity was assessed with the Fonseca Anamnestic Index (FAI), sleep quality with the Pittsburgh Sleep Quality Index (PSQI), oral habits with the Oral Behavior Checklist (OBC), and depression and anxiety status with the Hospital Anxiety and Depression Scale (HADS). In addition, mandibular movements were also evaluated.

Results
A total of 51 individuals (39 female, 12 male; mean age: 21.9 ± 3.8) were included in the study. There was a positive moderate correlation between FAI and OBC (r = 0.560, p < 0.01). PSQI (r = 0,373), VAS-jaw pain (r = 0,374, p < 0.05), VAS-neck pain (r = 0,437, p < 0.05) and HADS-D (r = 0,392, p < 0.05) were moderately associated with FAI. There was also a low correlation between FAI and HADS-A (r = 0.346, p < 0.05). A statistically significant predictive correlation was found between VAS-Neck pain and OBC with FAI (p < 0.05).

Conclusions
This study's results show that jaw and neck pain, sleep habits, oral habits, and anxiety-depression levels are associated with TMD severity. This association highlights the need to consider these factors in assessing and treating TMD.
Observed Glycemic and Psychosocial Benefits in the Prospective Bigfoot Unity Real World Study: A 6-Month Analysis
Authors: Tillman John B , Beck Roy W , Polonsky William H , Calhoun Peter , Mouse Thomas , Bailey Ryan , Jacoby Jeanne , Nandan Rakesh , Sheikh F Naureen , Malone James K 
Published: November 2024

Abstract

Context
The Bigfoot Unity Diabetes Management System integrates Abbott FreeStyle Libre 2 continuous glucose monitoring (CGM) data into a smart insulin pen cap and mobile app, enabling clinician-directed insulin dose recommendations and real-time alerts.

Objective
The objective was to analyze real-world 6-month glycemic control in a prospective study for individuals using the System for multiple daily insulin injections (MDI).

Methods
We conducted a 6-month analysis from the BURST study (NCT05088265) of individuals with type 1 or type 2 diabetes (T2D). Participants reported baseline demographics, adverse events, and other survey data electronically. Either at-home kit or electronic medical record glycated hemoglobin A1c (HbA1c) data were collected.

Results
Of 102 participants in the per protocol cohort, median age was 59 years, 87% had T2D, 42% used CGM previously, 62% were White non-Hispanic, and 59% female. Mean HbA1c decreased from 9.1 ± 1.7% at baseline to 8.0 ± 1.2% at 6 months (mean difference −1.1%, 95% CI −1.4 to −0.8, P &lt; .001). At 6 months, time in range (70-180 mg/dL), time at &lt; 70 mg/dL, and time at &lt; 54 mg/dL were 56 ± 23%, 1.0 ± 1.4%, and 0.04 ± 0.14%, respectively. Six severe hypoglycemia events occurred in 4 participants (none System-related) and no diabetic ketoacidosis events occurred in the per protocol cohort.

Conclusion
In this study primarily of older adults with T2D using MDI, durable glycemic improvement occurred using the System at 6 months, with the frequency of hypoglycemia being substantially below established targets of &lt; 4% and &lt; 1% for time below 70 and 54 mg/dL, respectively.
Delineating the Psychiatric Morbidity Spectrum in Congenital Adrenal Hyperplasia: A Population-based Registry Study
Authors: Lind-Holst Marie , Hansen Dorte , Main Katharina Maria , Juul Anders , Andersen Marianne Skovsager , Dunø Morten , Rasmussen Åse Krogh , Jørgensen Niels , Gravholt Claus Højbjerg , Berglund Agnethe 
Published: November 2024

Abstract

Context
Clinical studies of psychiatric morbidity in patients with congenital adrenal hyperplasia (CAH) imply impaired mental health.

Objective
To delineate psychiatric morbidity in a national CAH cohort by using complete data on psychiatric diagnoses from all Danish hospitals between 1977 and 2018 and on all psychiatric medication prescribed between 1995 and 2018.

Design
A registry-based cohort study.

Setting
A uniform public health care system.

Patients and controls
Four hundred and forty-eight patients (females: n = 215) with CAH, of which 410 had 21-hydroxylase deficiency (21-OHD) (females: n = 255) and 44 527 were age- and sex-matched general population controls.

Main outcome measures
Diagnoses were analyzed by negative binomial regression yielding incidence rate ratios (IRR). Medication were analyzed by Cox regression yielding hazard ratios (HR).

Results
21-OHD was associated with an increased risk of any psychiatric diagnosis; females: IRR = 2.32 (CI, 1.48-3.64), males: IRR = 2.74 (CI, 1.31-5.71) as well as of medication related to psychiatric disorders; females: HR = 1.74 (CI, 1.42-2.13), males: HR = 1.74 (CI, 1.30-2.33). Both females and males with 21-OHD had a significantly increased risk of alcohol use, stress and adjustment disorders, and of suicidal behavior. For patients with more rare forms of CAH (n = 24), the risk of any psychiatric diagnosis was significantly increased for males, IRR = 12.85 (CI, 1.78-92.87), but not for females, IRR = 0.54 (CI, 0.10-3.00). The risk of being prescribed psychiatric medication was not increased for neither females, HR = 1.05 (CI, 0.39-2.84), nor males, HR = 0.72 (CI, 0.10-5.13), with rare forms of CAH.

Conclusion
21-OHD is associated with a significantly increased psychiatric morbidity. This study underlines a need for awareness of mental health in patients with 21-OHD.
Cognitive Function in Individuals with Chronic Hypoparathyroidism—A Prospective Observational Study
Authors: Tmava-Berisha Adelina , Fahrleitner-Pammer Astrid , Stross Tatjana , Geiger Simon , Geiger Christina , Fellendorf Frederike , Scherkl Mario , Finner Alexander , Holl Anna , Dalkner Nina , Reininghaus Eva , Amrein Karin 
Published: November 2024

Abstract

Objective
“Brain fog” is a frequently reported, distressing experience among individuals with chronic hypoparathyroidism, characterized by reduced concentration and reduced ability to perform day-to-day tasks. However, evidence linking chronic hypoparathyroidism to cognitive impairment is limited and inconsistent. This study aimed to explore cognitive function in these patients using a validated neurocognitive test battery, compare results with a matched healthy control group, and analyze the frequency of cognitive impairment based on normative data.

Methods
The participants’ cognitive performance was tested using a cognitive test battery, including the Trail Making Test A/B, the Color-Word Interference Test, and the California Verbal Learning Test. These tests were used to evaluate the cognitive domains of attention and processing speed, verbal learning and memory, and executive function. In total, 30 individuals with hypoparathyroidism and 30 healthy controls were included.

Results
Twenty-four patients were women (80.0%), with a median age of 44.5 ± 13.1 and a median disease duration of 8.7 years (±5.3). Individuals with chronic hypoparathyroidism showed poorer cognitive performance in attention and processing speed [F(1,57) = 8.65, P = .005*, η2 = 0.13] compared to healthy controls. A significantly higher percentage of patients had cognitive deficits in both attention and processing speed (56.7% vs 3.3%) and executive function (60.0% vs 16.7%).

Conclusion
This study provides evidence that cognitive dysfunction, particularly in attention and processing speed, is common in chronic hypoparathyroidism. Recognizing cognitive impairment in these patients is crucial, especially when discussing workability. Neuropsychological training as an adjunct therapy strategy may be beneficial in managing these cognitive deficits.
Abrupt-mediated control of ninjurins regulates Drosophila sessile haemocyte compartments
Authors: Kwon So Yeon , Chan Kimberly , Stofanko Martin , Chan Ka Hei , Badenhorst Paul 
Published: November 2024

ABSTRACT
Macrophage-like cells called haemocytes are key effectors of Drosophila cellular innate immune function. Larval haemocytes exist either in circulation or localize to segmentally repeated sessile haemocyte compartments (SHCs). While numerous functions have been proposed for SHCs, the mechanisms directing haemocytes to them are unclear. Here, we have exploited the developmentally regulated dispersal of SHCs that occurs at pupariation to identify the Abrupt (Ab) transcription factor (TF) and ninjurin cell-adhesion molecules as regulators of haemocyte recruitment to SHCs. We show that larval haemocytes express ninjurins, which are required for targeting haemocytes to SHCs. However, at pupariation, ecdysteroid signalling stimulates Ab expression, which collaborates with TFs, including Blimp-1 and Hr3, to repress ninjurins and disperse haemocytes. We observe that experimental manipulations that antagonize ninjurin function in larval haemocytes cause premature SHC dispersal, while stabilization of ninjurins in haemocytes blocks developmentally regulated SHC remodelling and increases sensitivity to immune challenges. Cumulatively, our data indicate that control of ninjurin activity provides a common target through which diverse developmental, environmental and immune stimuli can be integrated to control haemocyte dispersal and immune function.
Three-dimensional anatomy and dorsoventral asymmetry of the mature Marchantia polymorpha meristem develops from a symmetrical gemma meristem
Authors: Spencer Victoria , Wallner Eva-Sophie , Jandrasits Katharina , Edelbacher Natalie , Mosiolek Magdalena , Dolan Liam 
Published: November 2024

ABSTRACT
Meristems are three-dimensional (3D) generative structures that contain stem cells and produce new organs and tissues. Meristems develop in all land plants; however we know little about the spatial and temporal regulation of meristem structure in lineages such as bryophytes. Here, we describe the 3D meristem anatomy during the development of the liverwort Marchantia polymorpha. We show that the apical stem cell of the mature meristem is sub-apical, ventral, and in the outer cell layer. Mature meristem anatomy is therefore asymmetrical in the dorsoventral axis, which is reflected by the domain-specific protein localisation of Class III and Class IV Homeodomain-Leucine-Zippers (MpC3HDZ and MpC4HDZ), and by the promoter activity of MpYUCCA2. The dorsoventral asymmetry that defines the mature meristem is absent in the juvenile meristems of asexual propagules known as gemmae. We discovered that anatomical dorsoventral asymmetry of the meristem forms after 1 to 2 days of gemmaling growth, and is accompanied by expression of the dorsal identity reporter MpC3HDZ. We conclude that the gemma meristem has arrested development and undergoes anatomical rearrangement to develop the 3D meristem structure of the mature plant.
The small ARF-like 2 GTPase TITAN5 is linked with the dynamic regulation of IRON-REGULATED TRANSPORTER 1
Authors: Mohr Inga , Eutebach Monique , Knopf Marie C. , Schommen Naima , Gratz Regina , Angrand Kalina , Genders Lara , Brumbarova Tzvetina , Bauer Petra , Ivanov Rumen 
Published: November 2024

ABSTRACT
Iron acquisition is crucial for plants. The abundance of IRON-REGULATED TRANSPORTER 1 (IRT1) is controlled through endomembrane trafficking, a process that requires small ARF-like GTPases. Only few components that are involved in the vesicular trafficking of specific cargo are known. Here, we report that the ARF-like GTPase TITAN5 (TTN5) interacts with the large cytoplasmic variable region and protein-regulatory platform of IRT1. Heterozygous ttn5-1 plants can display reduced root iron reductase activity. This activity is needed for iron uptake via IRT1. Fluorescent fusion proteins of TTN5 and IRT1 colocalize at locations where IRT1 sorting and cycling between the plasma membrane and the vacuole are coordinated. TTN5 can also interact with peripheral membrane proteins that are components of the IRT1 regulation machinery, like the trafficking factor SNX1, the C2 domain protein EHB1 and the SEC14-GOLD protein PATL2. Hence, the link between iron acquisition and vesicular trafficking involving a small GTPase of the ARF family opens up the possibility to study the involvement of TTN5 in nutritional cell biology and the endomembrane system.
Medicaid Expansion and Overall Survival of Lower Gastrointestinal Cancer Patients After Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy
Authors: Ramalingam Kirithiga , Ji Liang , O’Leary Michael P. , Lum Sharon S. , Caba Molina David 
Published: November 2024

Abstract
Background
In the United States, often only tertiary centers offer cytoreductive surgery and heated intraperitoneal chemotherapy (CRS+HIPEC) for peritoneal metastases in advanced lower gastrointestinal malignancies. Growing evidence shows that Medicaid expansion under the Affordable Care Act (ACA) of 2010 enhanced healthcare access and outcomes.

Objective
We sought to determine whether Medicaid expansion was associated with decreased all-cause mortality of lower gastrointestinal cancer patients following CRS+HIPEC.

Methods
We analyzed data from the National Cancer Database (2010–2019) on lower gastrointestinal cancer patients who underwent CRS+HIPEC. Medicaid expansion, introduced under the ACA in 2010, extends health insurance to low-income adults. We categorized states by expansion timing: early (2010–2013), immediate (January 2014), late (after January 2014), or no expansion to assess the impact of Medicaid expansion on mortality using a multivariable Cox regression model.

Results
Of the 1001 study patients, 671 (67%) were diagnosed in Medicaid expansion states. Grade and Medicaid expansion status were the only factors independently associated with overall survival on multivariable analysis. On average, patients in Medicaid expansion states experienced a 4% increase in annual survival compared with those in non-expansion states who had a 1% decrease in annual survival over the study period.

Conclusions
Patients from states that had an early expansion of Medicaid and patients with lower-grade tumors had significantly better overall survival. Our study findings suggest that improved access to healthcare through Medicaid expansion was associated with increased survival rates of lower gastrointestinal cancer patients who undergo CRS+HIPEC for the treatment of peritoneal metastases.
Partial response to treatment with ALK inhibitor in a patient with SQSTM1-ALK fusion positive lung adenocarcinoma
Authors: Rodriguez Arroyo Brenda Paola , Mondragón-Cardona Alvaro , Pacheco-Orozco Rafael Adrián , Tamayo Andrea , Moreno Juan Camilo , Baena-Valencia Juan Camilo 
Published: November 2024

Introduction: Lung cancer is the second most common cancer worldwide and the leading cause of cancer deaths; non-small cell lung cancer (NSCLC) constitutes about 85% of lung cancer cases, with ALK fusions representing 3–6% of them. The SQSTM1-ALK fusion is a rare finding in NSCLC, accounting for only 1.1% of ALK rearrangements. We present a case of lung adenocarcinoma with documentation of SQSTM1-ALK fusion that showed a partial response to alectinib. Case description: This case details the clinical course of a 71-year-old, non-smoking woman with no significant medical history who presented with confusion, aphasia and multiple cerebral lesions detected on imaging. Further investigations revealed a stage IV lung adenocarcinoma with metastases to the brain and adrenal gland. Molecular profiling identified a rare SQSTM1-ALK fusion mutation alongside other genetic abnormalities, including low programmed death-ligand 1 expression and ROS1 kinase protein presence. Treatment with alectinib, initiated based on the identified ALK fusion, resulted in significant tumour regression in the lungs and complete resolution of the adrenal mass, as evidenced by follow-up imaging and clinical assessments. Conclusion: This case highlights the efficacy of alectinib in treating rare ALK fusion variants in and underscores the importance of comprehensive molecular profiling in guiding targeted therapy decisions.
Risk factors for conversion to thoracotomy in patients with lung cancer undergoing video-assisted thoracoscopic surgery: A meta-analysis
Authors: Wang Siyu , Yan Hong , Wen Jun , Zhou Zitong , Xu Jialan 
Published: November 2024

Objective
To systematically evaluate the risk factors of conversion to thoracotomy in thoracoscopic surgery (VATS) for lung cancer, and to provide a theoretical basis for the development of personalized surgical plans.

Methods
CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, Web of Science, and Embase databases were searched by computer from the establishment of the database to March 2024. Relevant studies on the risk factors of conversion to thoracotomy in VATS for lung cancer were searched. Two reviewers independently performed literature screening, data extraction, and quality evaluation, and Stata16.0 software was used for data analysis.

Results
A total of 14 studies were included in this study, with a total sample size of 10605, and a total of 11 risk factors were obtained. Mate analysis showed that, Age ≥ 65 years old [OR(95%CI) = 2.61(1.67,4.09)], male [OR(95%CI) = 1.46(1.19,1.79)], BMI(Body Mass Index) ≥ 25 [OR(95%CI) = 1.79(1.17,2.74)], tuberculosis history [OR(95%CI) = 7.67(4.25,13.83)], enlarged mediastinal lymph nodes [OR(95%CI) = 2.33(1.50,3.06)], lung door swollen lymph nodes [OR(95%CI) = 6.33(2.07,19.32)], pleural adhesion [OR(95%CI) = 2.50(1.93,3.25)], tumor located in the lung Upper lobe [OR(95%CI) = 4.01(2.87,5.60)], sleeve lobectomy [OR(95%CI) = 3.40(1.43,8.08)], diameter of tumor ≥ 3.5cm [OR(95%CI) = 2.13(1.15,3.95)] associated with lung cancer VATS transit thoracotomy.

Conclusions
Age ≥ 65 years old, male, BMI ≥ 25, tuberculosis history, enlarged mediastinal lymph nodes, lung door swollen lymph nodes, pleural adhesion, tumor located in the lung Upper lobe, sleeve lobectomy, diameter of tumor ≥ 3.5cm are risk factors for conversion to thoracotomy during VATS for lung cancer. Clinicians should pay attention to the above factors before VATS to avoid forced conversion due to the above factors during VATS. Due to the number and limitations of the included studies, the above conclusions need to be validated by additional high-quality studies.

Trail registration
The protocol was registered into the PROSPERO database under the number CRD42023478648.