bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug-Resistant Myoclonic Epilepsy Revealing Juvenile Huntington's Disease: A Case Report
Authors: Feki Fatma , Triki Chahnez , Amara Nesrine 
Published: April 2018

AbstractJuvenile Huntington's disease (JHD) shares many general clinical features with the adult form. One important difference is that JHD patients experience more epileptic manifestations, sometimes difficult to control. We describe an atypical clinical picture of a genetically confirmed JHD patient diagnosed during evaluation for a progressive myoclonic epilepsy. A female patient with a family history of psychiatric disorders developed recurrent drug-resistant myoclonic seizures at the age of 6 years, followed by extrapyramidal symptoms (rigidity and dystonia). Cognitive impairment, akinetic rigidity syndrome, and dystonia were noticed at the age of 10 years. Epileptiform abnormalities were noted in ictal electroencephalography. Magnetic resonance imaging showed brain atrophy. Genetic testing for HD confirmed the diagnosis. JHD can initially manifest as myoclonic epilepsy. A DNA testing should be performed if clinical history is suggestive.
Immuntherapien beim fortgeschrittenen NSCLC
Authors: Reck Martin , Schütte Wolfgang , Dickgreber Nicolas , Reinmuth Niels , Wehler Thomas , Morris Stefanie , Rittmeyer Achim , Weichert Wilko 
Published: April 2018

ZusammenfassungDer Einzug von Immuntherapien mit Checkpoint-Inhibitoren in die Behandlung des fortgeschrittenen nicht kleinzelligen Lungenkarzinoms (NSCLC) hat die Erst- und Zweitlinientherapie revolutioniert. Nach langem therapeutischem Stillstand für die große Gruppe von Patienten ohne therapierbare Treibermutationen stehen nun erstmals neue Behandlungsoptionen zur Verfügung. Aktuell werden Kombinationstherapien geprüft, die das Potenzial der Immuntherapien noch besser ausschöpfen sollen. Für den Kliniker heißt das aber auch, dass die Therapieentscheidungen beim metastasierten NSCLC immer komplexer werden. Daher möchte die vorliegende Publikation vor allem folgende Fragen beantworten: Wie verändern die aktuell etablierten Immuntherapien unser Vorgehen in der klinischen Praxis? Welche Kriterien eignen sich zur Auswahl geeigneter Therapieschemata? Welche Herausforderungen müssen zukünftig noch gemeistert werden?
Halt trotz begrenzter Möglichkeiten
Authors: Reiland Kirsten 
Published: April 2018

Zusammenfassung
Fixierung von Pleuradrainagen Eine Pleuradrainage bei Früh- und Neugeborenen ist eher selten notwendig. Kommt sie dennoch einmal vor, fehlt dem pflegerischen, aber auch dem ärztlichen Team die Routine. Die Möglichkeiten der Fixierung sind begrenzt, denn die Körperoberfläche ist sehr klein. Und auch Umgebungsfaktoren wie die Versorgung im Inkubator mit hoher Feuchtigkeit erschweren die Fixierung. Oft kommt es deshalb im Team zu unterschiedlichem Vorgehen und zur Verwendung unterschiedlicher Materialien. Autorin Kirsten Reiland stellt die verschiedenen Fixierungsmöglichkeiten vor.
Proposal of a management system to develop an animal welfare strategy for the animal food chain.
Authors: Souza A. P. de O. , Molento C. F. M. 
Published: April 2018

Abstract
This study aimed to propose general guidelines for an animal welfare (AW) management system based on the hazard analysis and critical control point (HACCP) to develop an AW strategy appropriate for individual organizations of the animal food chain. Main adaptations for steps within pre-hazard analysis included a description of the animal species and its intended use, the development of a flow diagram detailing operations where live animals are handled and focusing on animal handling procedures for each stage of animal production or process step. The hazard analysis step included considerations of all kinds of welfare problems that may occur in each step or production stage listed in the flow diagram. Hazard duration, including duration of its consequences, were added to the hazard characterization step. Main changes on establishing critical limits for critical control points included a proposal to set initial thresholds for animal-based measures while scientific-validated data are obtained. Corrective actions considered the concept of implementing real-time procedures to avoid animal suffering, as well as the possibility of reducing identified hazards for future animals. By implementing the HACCP-based system, companies will be prompted to reduce levels of identified AW problems, with potential for mid to long-term reduction of AW problems through planned corrective and preventive actions. Application of the management system may take broader AW discussions to higher corporate levels in companies, needed for the development of an AW strategy, and may promote transparency of processes in animal production, which will benefit both animals and society.
Numerical evidences of universal trap-like aging dynamics
Authors: Cammarota Chiara , Marinari Enzo 
Published: April 2018

Abstract
Trap models have been initially proposed as toy models for dynamical relaxation in extremely simplified rough potential energy landscapes. Their importance has recently grown considerably thanks to the discovery that the trap-like aging mechanism directly controls the out-of-equilibrium relaxation processes of more sophisticated spin models, that are considered as the solvable counterpart of real disordered systems. Further establishing the connection between these spin models, out-of-equilibrium behavior and the trap like aging mechanism could shed new light on the properties, which are still largely mysterious, for the activated out-of-equilibrium dynamics of disordered systems. In this work we discuss numerical evidence based on the computations of the permanence times of an emergent trap-like aging behavior in a variety of very simple disordered models—developed from the trap model paradigm. Our numerical results are backed by analytic derivations and heuristic discussions. Such exploration reveals some of the tricks needed to reveal the trap behavior in spite of the occurrence of secondary processes, of the existence of dynamical correlations and of strong finite system’s size effects.
Structure Optimization of Porous Dental Implant Based on 3D Printing
Authors: Ji Fangqiu , Zhang Chunyu , Chen Xianshuai 
Published: April 2018

Abstract
In this paper, selective laser melting (SLM) technology is used to process complex structures. In combination with the theory of biomedicine, a porous implant with a porous structure is designed to induce bone cell growth. The mechanical strength advantage of SLM was discussed by observing the metallographic structure of SLM specimen with mechanical microscope and mechanical tensile test. The osseointegration of porous implants was observed and analyzed by biological experiments. By establishing a mechanical model, the mechanical properties of the bone implant combined with the jaw bone were studied by the simple mechanical analysis under static multi loading and the finite element mechanical analysis. According to the experimental observation and mechanical research, the optimization suggestions for the structure design of the implant made by SLM technology were put forward.
Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-Hypertensive Community-Based Population
Authors: Tanaka Kentaro , Tanaka Fumitaka , Onoda Toshiyuki , Tanno Kozo , Ohsawa Masaki , Sakata Kiyomi , Omama Shinichi , Ogasawara Kuniaki , Ishibashi Yasuhiro , Itai Kazuyoshi , Kuribayashi Toru , Okayama Akira , Nakamura Motoyuki ,   Iwate-Kenco Study Group
Published: April 2018

Abstract

BACKGROUND
The appearance of left ventricular hypertrophy on 12-lead electrocardiography (ECG-LVH) has been clarified to be associated with the risk of incidence of cardiovascular events (CVEs) in hypertensive individuals and the general population, but not enough in non-hypertensive individuals.

METHODS
A total of 4,927 non-hypertensive individuals ≥40 years of age who were free of CVE in the general population were followed for the incidence of CVE. ECG-LVH was defined according to criteria of the Sokolow-Lyon (SL) voltage, Cornell voltage (CV), or Cornell voltage product (CP).

RESULTS
During the average 9.8 ± 2.0 years of follow-up, 267 individuals (5.4%) had their first CVE. The hazard ratio (HR) for the incidence of CVE after full adjustment by potential confounders significantly increased in the individuals with ECG-LVH by any criteria of the SL voltage, CV, and CP (HR = 1.77, P &lt; 0.001) compared to those with no ECG-LVH. This association was also significant in individuals without any of obesity, dyslipidemia, and diabetes mellitus or those with systolic blood pressure (BP) &lt;120 mm Hg and diastolic BP &lt;80 mm Hg. Furthermore, ECG-LVH by each criteria provided the reclassification improvement for the CVE risk prediction model by the Framingham 10-year risk score (the net reclassification improvement = 0.17–0.22, each P value &lt; 0.010).

CONCLUSIONS
In the absence of hypertension, ECG-LVH parameters are associated with the increased risk of developed CVEs independent of the established risk factors and provide the additional prognostic value in an assessment of the CVE risk using the traditional risk factors.
A comprehensive web tool for toehold switch design
Authors: To Andrew Ching-Yuet , Chu David Ho-Ting , Wang Angela Ruoning , Li Frances Cheuk-Yau , Chiu Alan Wai-On , Gao Daisy Yuwei , Choi Chung Hang Jonathan , Kong Siu-Kai , Chan Ting-Fung , Chan King-Ming , Yip Kevin Y 
Published: April 2018

Abstract

Motivation
Toehold switches are a class of RNAs with a hairpin loop that can be unfolded upon binding a trigger RNA, thereby exposing a ribosome binding site (RBS) and permitting translation of the reporter protein. They have been shown very useful in detecting a variety of targets including RNAs from Zika and Ebola viruses. The base complementation between the toehold switch and the trigger RNA also makes it sensitive to sequence variations. Design of toehold switches involves a series of considerations related to their sequence properties, structures and specificities.

Results
Here we present the first comprehensive web tool for designing toehold switches. We also propose a score for predicting the efficacy of designed toehold switches based on properties learned from ∼180 experimentally tested switches.

Availability and implementation
The toehold switch web tool is available at https://yiplab.cse.cuhk.edu.hk/toehold/.
Psychometric evaluation of the Smartphone for Clinical Work Scale to measure nurses’ use of smartphones for work purposes
Authors: Bautista John Robert , Rosenthal Sonny , Lin Trisha Tsui-Chuan , Theng Yin-Leng 
Published: April 2018

Abstract

Objective
This study reports the development and psychometric evaluation of the Smartphone for Clinical Work Scale (SCWS) to measure nurses’ use of smartphones for work purposes.

Methods
Items were developed based on literature review and a preliminary study. After expert consultations and pilot testing, a 20-item scale was administered in January-June 2017 to 517 staff nurses from 19 tertiary-level general hospitals in Metro Manila, Philippines. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to evaluate construct validity. Structural equation modeling (SEM) was used to test the predictive validity of SCWS on perceived work productivity.

Results
EFA results show that 15 out of 20 items loaded on five factors: communication with clinicians via call and text, communication with doctors via instant messaging, information seeking, communication with nurses via instant messaging, and communication with patients via call and text. CFA results suggest that the five factors that form SCWS have adequate fit to the data, thus supporting construct validity. SEM results suggest predictive validity since SCWS was positively associated with perceived work productivity.

Conclusions
The 15-item SCWS showed satisfactory psychometric properties for use in future studies. These studies can focus on identifying factors associated with nurses’ use of smartphones for work purposes.
Affordability and Price Increases of New Cancer Drugs in Clinical Guidelines, 2007–2016
Authors: Hwang Thomas J , Kesselheim Aaron S , Gyawali Bishal 
Published: April 2018

Abstract
In response to the rising cost of cancer drugs, the National Comprehensive Cancer Network (NCCN) recently developed a value framework, known as “Evidence Blocks,” to grade the efficacy, safety, evidence quality, evidence consistency, and affordability of treatments included in its clinical guidelines. The value scores were available for 55 of the 69 new cancer drugs approved by the US Food and Drug Administration from 2007 to 2016. Overall, the treatment costs for 95% of new cancer medicines in NCCN clinical guidelines were scored as “very expensive” or “expensive”. In multivariable ordered logistic regression models, there was no association between the affordability of new cancer drugs and efficacy and safety data available in clinical guidelines. Most guideline-recommended drugs were subject to annual list price increases exceeding inflation.
The cosmic transparency measured with Type Ia supernovae: implications for intergalactic dust
Authors: Goobar Ariel , Dhawan Suhail , Scolnic Daniel 
Published: April 2018

Abstract
Observations of high-redshift Type Ia supernovae (SNe Ia) are used to study the cosmic transparency at optical wavelengths. Assuming a flat Λ cold dark matter (ΛCDM) cosmological model based on baryon acoustic oscillations and cosmic microwave background measurements, redshift dependent deviations of SN Ia distances are used to constrain mechanisms that would dim light. The analysis is based on the most recent Pantheon SN compilation, for which there is a $0.03 \pm 0.01 \, {(\rm {stat})}$ mag discrepancy in the distant supernova distance moduli relative to the ΛCDM model anchored by supernovae at z &lt; 0.05. While there are known systematic uncertainties that combined could explain the observed offset, here we entertain the possibility that the discrepancy may instead be explained by scattering of supernova light in the intergalactic medium (IGM). We focus on two effects: Compton scattering by free electrons and extinction by dust in the IGM. We find that if the discrepancy is entirely due to dimming by dust, the measurements can be modelled with a cosmic dust density $\Omega _{\rm IGM}^{\rm dust} = 8 \times 10^{-5} (1+z)^{-1}$, corresponding to an average attenuation of 2 × 10−5 mag Mpc−1 in V band. Forthcoming SN Ia studies may provide a definitive measurement of the IGM dust properties, while still providing an unbiased estimate of cosmological parameters by introducing additional parameters in the global fits to the observations.
Gradient pattern analysis applied to galaxy morphology
Authors: Rosa R R , de Carvalho R R , Sautter R A , Barchi P H , Stalder D H , Moura T C , Rembold S B , Morell D R F , Ferreira N C 
Published: April 2018

Abstract
Gradient pattern analysis (GPA) is a well-established technique for measuring gradient bilateral asymmetries of a square numerical lattice. This paper introduces an improved version of GPA designed for galaxy morphometry. We show the performance of the new method on a selected sample of 54 896 objects from the SDSS-DR7 in common with Galaxy Zoo 1 catalogue. The results suggest that the second gradient moment, G2, has the potential to dramatically improve over more conventional morphometric parameters. It separates early- from late-type galaxies better (${\sim } 90\hbox{ per cent}$) than the CAS system ($C\sim 79\hbox{ per cent}, A\sim 50\hbox{ per cent}, S\sim 43\hbox{ per cent}$) and a benchmark test shows that it is applicable to hundreds of thousands of galaxies using typical processing systems.
Stereotactic Radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study
Authors: Ding Dale , Mehta Gautam U , Patibandla Mohana Rao , Lee Cheng-Chia , Liscak Roman , Kano Hideyuki , Pai Fu-Yuan , Kosak Mikulas , Sisterson Nathaniel D , Martinez-Alvarez Roberto , Martinez-Moreno Nuria , Mathieu David , Grills Inga S , Blas Kevin , Lee Kuei , Cifarelli Christopher P , Katsevman Gennadiy A , Lee John Y K , McShane Brendan , Kondziolka Douglas , Lunsford L Dade , Vance Mary Lee , Sheehan Jason P 
Published: April 2018

Abstract

BACKGROUND
Stereotactic radiosurgery (SRS) is a treatment option for persistent or recurrent acromegaly secondary to a growth hormone secreting pituitary adenoma, but its efficacy is inadequately defined.

OBJECTIVE
To assess, in a multicenter, retrospective cohort study, the outcomes of SRS for acromegaly and determine predictors.

METHODS
We pooled and analyzed data from 10 participating institutions of the International Gamma Knife Research Foundation for patients with acromegaly who underwent SRS with endocrine follow-up of ≥6 mo.

RESULTS
The study cohort comprised 371 patients with a mean endocrine follow-up of 79 mo. IGF-1 lowering medications were held in 56% of patients who were on pre-SRS medical therapy. The mean SRS treatment volume and margin dose were 3.0 cm3 and 24.2 Gy, respectively. The actuarial rates of initial and durable endocrine remission at 10 yr were 69% and 59%, respectively. The mean time to durable remission after SRS was 38 mo. Biochemical relapse after initial remission occurred in 9%, with a mean time to recurrence of 17 mo. Cessation of IGF-1 lowering medication prior to SRS was the only independent predictor of durable remission (P = .01). Adverse radiation effects included the development of ≥1 new endocrinopathy in 26% and ≥1 cranial neuropathy in 4%.

CONCLUSION
SRS is a definitive treatment option for patients with persistent or recurrent acromegaly after surgical resection. There appears to be a statistical association between the cessation of IGF-1 lowering medications prior to SRS and durable remission.
Novice and Expert Clinical Instructors: A Method to Enhance Teaching Capabilities
Authors: Roman Tammy 
Published: April 2018

Abstract
Due to scarce opportunities for professional development in clinical teaching, an online learning community was developed to provide initial and ongoing education for novice and experienced clinical instructors. Asynchronous learning modules were developed that included discussion boards to share best practices. Results demonstrated a significant change in the participants’ knowledge of clinical teaching as well as the identification of a lack of confidence among novice instructors (p < .05). This research establishes the benefit of a learning community for both new and experienced clinical instructors and the need to increase confidence in their teaching abilities.
Relationship of Ethical Knowledge to Action in Senior Baccalaureate Nursing Students
Authors: Moe Catherine S. 
Published: April 2018

Abstract
It is not known if nursing graduates have skills to manage ethical clinical situations. This study examined the relationship between knowledge of ethics to choices of action in baccalaureate nursing students. It explored individual student characteristics to determine what impact these have on the relationship between knowledge and action. A significant correlation between knowledge of ethics and action was found. College courses on ethics, previous experience in making health care decisions, or general health care experience did not significantly impact this relationship, but the data trended toward significance with previous experience in making decisions and supported a need for further research.
Screening women for intimate partner violence
Authors: Knox Beth 
Published: April 2018

Abstract:
Intimate partner violence continues to be a challenge for advanced practice registered nurses to address and manage in their daily practice. This article reviews current healthcare concerns in heterosexual, bisexual, transgender, and lesbian women, and explores screening guidelines and resources for developing successful screening habits. Additionally, the article discusses how the Transtheoretical Model and Stages of Change offers insight into the behavior of women who experience intimate partner violence and provides safety strategies for these women.
Unilateral Lateral Epicondylalgia Shows a Pro-nociceptive Pain Profile
Authors: Bisset Leanne , Carty Michelle , Smith Ashley 
Published: April 2018

Objective:
Lateral epicondylalgia (LE, tennis elbow) is characterized by both local tissue pathology and features indicative of secondary hyperalgesia. The aim of this study was to evaluate endogenous pain modulation characteristics in people with chronic LE, and to investigate the relationship between endogenous pain modulation and clinical characteristics.

Materials and Methods:
This case-control observational study included 25 participants with LE of at least 6 weeks’ duration and 15 age-matched (±5 y) healthy control participants, who were each evaluated in a single session. Pain and disability were assessed using the patient-rated tennis elbow evaluation and pain-free grip strength. Endogenous pain modulation was assessed using pressure pain threshold, cold pain threshold, conditioned pain modulation (CPM), and temporal summation (TS).

Results:
The LE group exhibited significantly lower pain-free grip and pressure pain threshold bilaterally compared with the control group. Cold pain threshold was significantly reduced on the affected side compared with the matched control side. There was no significant difference between groups for CPM; however, the LE group exhibited significantly increased facilitation as measured by TS (between-group difference in change score of 9.6 mm on a 0 to 100 mm pain visual analogue scale; 95% confidence intervals, 3.4-15.8 mm). There was no significant correlation between pain modulation and clinical measures of pain and disability.

Discussion:
LE is characterized by locally increased facilitation of pain, as measured by TS, but this is not associated with severity of pain or disability.
Total Endoprosthesis Versus Lundborg´s Resection Arthroplasty for the Treatment of Trapeziometacarpal Joint Osteoarthritis
Authors: Erne Holger , Scheiber Claudia , Schmauss Daniel , Loew Steffen , Cerny Michael , Ehrl Denis , Schmauss Verena , Machens Hans-Guenter , Muhl Philipp 
Published: April 2018

Background:
There exist various operative approaches for the treatment of trapeziometacarpal joint osteoarthritis. The aim of this study was to compare the results of Lundsborg’s resection arthroplasty (RA) with implantation of a total endoprosthesis.

Patients and Methods:
In this 2-center study, we retrospectively analyzed 71 patients with symptomatic osteoarthritis of the carpometacarpal I joint stage III according to the Eaton-Littler classification. Thirty-two patients underwent a Lundsborg’s RA group, and 39 patients received a total endoprosthesis of the carpometacarpal I joint (TEP group). We evaluated operative time, DASH score, postoperative time until resolution of symptoms, pain level, pinch force, and satisfaction with the treatment.

Results:
Both groups had a similar mean length of follow-up of 42 months (TEP group) and 36 months (RA group). The final DASH score was significantly better in the TEP-group (10.1 versus 21.5 in the RA group; P ≤ 0.05). Also, the time interval from surgery till absence of any pain (1.5 versus 5.9 months) and the time of inability to work (6 versus 21 weeks) were significantly shorter for the TEP group compared with the RA group (P ≤ 0.05). The pinch force, pain intensity, and the satisfaction with the treatment were comparable (P > 0.05). The duration of the operation was significantly shorter in the RA group (31 min versus 65 min in the TEP group; P ≤ 0.05).

Conclusion:
Both techniques resulted in improved function of the operated hand and a clear reduction of symptoms. However, the implantation of a total endoprosthesis seems to have advantages, given a significantly better DASH score and a significantly shorter time until resolution of symptoms.