bluuebunny/crossref_metadata_2025_split huggingface dataset:
The immunological impact of orthomolecular medicine using bioactive compounds as key factors in endometriosis
Authors: Vlachos Alexandros , Vassiliadis Simon 
Published: May 2019

Background: Endometriosis, an inflammatory, non-lethal, non-malignant disease, still has unjustified etiology. Among many, the theory dealing with this review claims that a suppressed or incompetent immune system that is totally unable to eradicate the non-hemopoietic mesenchymal endometriotic stem cell (MESC) escapes immune surveillance. As a result, there is migration and invasion of the aforementioned cell to ectopic tissues causing the disease. Keywords: bioactive compounds, functional foods, endometriosis, orthomolecular medicine, mesenchymal endometriotic stem cell (MESC), immune system
Importance of food plants in the prevention and treatment of diabetes in Cameroon
Authors: Tsabang Nole , W. Lionel , Yedjou Clément G. , Tchounwou Paul B. 
Published: May 2019

Background: Diabetes is a metabolic pathology that affects the human body’s capacity to produce and use insulin. Type 1 (insulin-dependent) diabetes accounts for 5-10 % of diabetic patients. In Type 2 diabetes the insulin produced by the pancreatic islets is not properly used by cells leading to insulin resistance. Gestational diabetes sometimes occurs in pregnant women and affects about 18 % of all pregnancies. Diabetes is one of the most important multifactorial, metabolic and chronic diseases, with fatal complications. According to the International Diabetes Federation’s estimations in 2015, 415 million people had diabetes. By 2040 this will increase to 642 million. Although many ethnopharmacological surveys have been carried out in several parts of the world, no ethnomedical and ethnopharmacological surveys have been done to identify plants used for the prevention and treatment of diabetes.Objective: This study aimed to collect and document information on food plants’ remedies consumed for preventing and treating diabetes in Cameroon.Methods: Ethnomedical and ethnopharmacological thorough preparation was conducted nearby 1131 interviewers from 58 tribes, in a random distribution. Diabetic patients recorded among the 1,131 people who signed the informed consent and allowed us to evaluate the effectiveness of 10 food plants that they usually used in self-medication. They were divided into two groups: Group 1 was comprised of 42 diabetic patients who regularly consume certain food plants, and Group 2 included 58 patients who were town dwellers and did not regularly eat the identified food plants. Results: It was discovered that the times of onset of diabetes in patients were about 70 years and 45 years in Group 1 and Group 2, respectively. Hence, it was demonstrated that the onset of diabetes was linked to consumption of food plants which contributed to the prevention and/or the delay in its clinical manifestations.Conclusion: The results of this study provide a scientific basis for the use of herbal medicines in the management of diabetes. However further investigations and/or clinical trials involving a large number of both type 1 and type 2 diabetics are needed to confirm the therapeutic action of many food plants against diabetes.Keywords: Cameroon, food plants, diabetes, prevention and treatment
Neuropsychological Similarities and Differences Between Amnestic Alzheimer’s Disease and its Non-Amnestic Variants
Authors: Mendez Mario F. , Monserratt Lorena H. , Liang Li-Jung , Chavez Diana , Jimenez Elvira E. , Maurer Joseph J. , Laffey Megan 
Published: May 2019

Background: The neuropsychological recognition of early-onset Alzheimer’s disease (AD) can be difficult because of non-amnestic variants such as logopenic variant primary progressive aphasia (lvPPA) and posterior cortical atrophy (PCA). Objective: This study evaluated the similarities and differences between typical amnestic AD (tAD) and lvPPA and PCA on a screening neuropsychological battery. Methods: We enrolled 51 patients meeting NIA-AA criteria for biomarker-supported AD (amnestic or non-amnestic) and having an age of onset of <65 years of age. Based on additional recommended clinical criteria for lvPPA and PCA, the early-onset AD patients were divided into three groups (28 tAD, 9 lvPPA, 14 PCA) of comparable age and dementia severity. We then analyzed their profiles on a focused, screening neuropsychological battery for early-onset AD. Results: In addition to greater variance on the Mini-Mental State Examination, the lvPPA and PCA variants had episodic memory impairment that did not significantly differ from the memory impairment in the tAD patients. Despite differences on language and visuospatial tasks, they did not significantly distinguish the lvPPA and PCA from tAD. The lvPPA group, however, was distinguishable by worse performance on measures reflecting working memory (digit span forward, memory registration). Conclusions: On neuropsychological screening, all clinical early-onset AD subtypes may have memory impairments. Screening batteries for early-onset AD should also include measures of working memory, which is disproportionately decreased in lvPPA.
Higher Body Mass Index Is Associated with Lower Cortical Amyloid-β Burden in Cognitively Normal Individuals in Late-Life
Authors: Thirunavu Vineeth , McCullough Austin , Su Yi , Flores Shaney , Dincer Aylin , Morris John C. , Cruchaga Carlos , Benzinger Tammie L.S. , Gordon Brian A. 
Published: May 2019

Background: Both low and high body mass index (BMI) have been associated with an increased risk of dementia, including that caused by Alzheimer’s disease (AD). Specifically, high middle-age BMI or a low late-age BMI has been considered a predictor for the development of AD dementia. Less studied is the relationship between BMI and AD pathology. Objective: We explored the association between BMI and cortical amyloid-β (Aβ) burden in cognitively normal participants that were either in mid-life (45–60 years) or late-life (>60). Methods: We analyzed cross-sectional baseline data from the Knight Alzheimer Disease Research Center (ADRC) at Washington University. Aβ pathology was measured in 373 individuals with Aβ PET imaging and was quantified using Centiloid units. We split the cohort into mid- and late-life groups for analyses ( n = 96 and n = 277, respectively). We ran general linear regression models to predict Aβ levels from BMI while controlling for age, sex, years of education, and APOE4 status. Analyses were also conducted to test the interaction between BMI and APOE4 genotype and between BMI and sex. Results: Higher BMI was associated with lower cortical Aβ burden in late-life (β= –0.81, p = 0.0066), but no relationship was found in mid-life (β= 0.04, p > 0.5). The BMI× APOE4+ and BMI×male interaction terms were not significant in the mid-life (β= 0.28, p = 0.41; β= 0.64, p = 0.13) or the late-life (β= 0.17, p > 0.5; β= 0.50, p = 0.43) groups. Conclusion: Higher late-life BMI is associated with lower cortical Aβ burden in cognitively normal individuals.
Efficacy and Safety of Glycogen Synthase Kinase 3 Inhibitors for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Authors: Matsunaga Shinji , Fujishiro Hiroshige , Takechi Hajime 
Published: May 2019

Background: The efficacy and safety of glycogen synthase kinase 3 (GSK-3) inhibitors in patients with Alzheimer’s disease (AD) is unknown. Objective: A systematic review and meta-analysis of randomized controlled trials (RCTs) to test GSK-3 inhibitors on AD patients. Methods: We included RCTs of GSK-3 inhibitors in AD patients and subjects with mild cognitive impairment (MCI), using cognitive function scores as a primary measure. Results: Five RCTs (three RCTs using lithium and two RCTs using tideglusib) with 568 patients were included. There was no significant difference in cognitive function scores between the GSK-3 inhibitors and placebo groups [standardized mean difference (SMD) = –0.25, p = 0.11, I2 = 55% ]. However, significant heterogeneity remained. A sensitivity analysis revealed that the lithium subgroup was more effective on cognitive function scores than placebo for AD and MCI (lithium subgroup: SMD = –0.41, p = 0.04; tideglusib subgroup: SMD = –0.02, p = 0.89). Moreover, a meta-regression analysis showed that the effect size of GSK-3 inhibitors on cognitive function scores was associated with study duration (coefficient, –0.0116). For safety outcomes, tideglusib was associated with a higher incidence of increased aspartate aminotransferase than placebo. There were no significant differences in other secondary outcomes between treatments. Conclusion: Our results suggested that GSK-3 inhibitors were ineffective in treating AD and MCI; however, several studies included in the present meta-analysis were small, and future studies using a larger sample size are needed.
Fatigue in Parkinson’s Disease Associates with Lower Ambulatory Diastolic Blood Pressure
Authors: Kotagal Vikas , Szpara Ashley , Albin Roger L. , Bohnen Nicolaas I. 
Published: May 2019

Background/Objective: Fatigue is a common debilitating symptom in Parkinson’s disease (PD) of unclear etiology. Hypotension and blood pressure variability are common in PD though their relationship to other non-motor symptoms is less well understood. Methods: We conducted a cross-sectional study to explore differences in 24-hour ambulatory blood pressure measurements in PD subjects ( n = 35) with and without fatigue. Subjects underwent hourly systolic (SBP) and diastolic (DBP) blood pressure testing in their home environment. The presence of fatigue was assessed using the Movement Disorders Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part 1. We compared blood pressure measurements in fatigued vs. non-fatigued PD subjects, assessed over 4 epochs: overnight, morning, midday, and evening. Results: PD subjects with symptoms of fatigue demonstrated lower mean DBP, compared to those without fatigue (67.8±4.8 mmHg vs. 75.6±9.4 t = 2.57, p = 0.014). These intergroup differences were most notable in the morning. The two groups did not differ in scoring on the Survey of Autonomic Symptoms or on an office-based blood assessment of SBP or DBP performed on the day of 24-hour monitor initiation. Conclusions: Fatigue in PD may be a clinical manifestation of low-grade systemic hypotension.
Comparative analysis of 13 HPV genotypes diagnosed in urine sediment cells vs. desquamated cervical epithelial cells
Authors: Owczarek MA , Kałużewski T , Kucharska D , Bednarek M , Morel A , Jędrzejczyk A , Kałużewski B 
Published: May 2019

<p>ABSTRACT</p>
<p>INTRODUCTION. The human papilloma virus (HPV) belongs to double-stranded, DNA circular viruses which infect the epithelial cells. The highest incidence of HPV is identified in malignant processes which affect the uterine cervix, as well as vulvar, penile, rectal and pharyngeal regions.<br />GOAL OF STUDY. An attempt to find correlations between HPV incidence rates in urine sediment cells and in desquamated epithelial cells of the uterine cervix in a group of patients with frequent, recurrent cystitis.<br />MATERIALS AND METHODS. HPV presence was studied, both in urine sediment cells and in uterine cervix epithelial cells of 77 patients.<br />RESULTS. An analysis of urinary sediments brought a total of twenty (25.97%) positive and 57 (74.03%) negative results. In turn, an evaluation of uterine cervix material samples revealed 17 (22.08%) positive and 60 (77.92%) negative results.<br />CONCLUSIONS. The study enabled a comparison between HPV prevalence rates in urine sediment cells and in uterine cervix epithelial cells of an examined patient. The performed observations are likely to trigger a further analysis of the studied issue; however, the obtained results provide arguments for different natural histories of the infection processes.</p>
<p>STRESZCZENIE</p>
<p>WSTĘP. W przypadku raka urotelialnego jednym z potencjalnych czynników rakotwórczych jest wirus brodawczaka ludzkiego (HPV). Ludzki wirus brodawczaka należy do dwuniciowych wirusów DNA infekujących komórki nabłonka. Największa częstość występowania HPV stwierdzono w złośliwych procesach, które mają wpływ na szyjkę macicy, a także na okolice sromu, prącia, odbytnicy oraz gardła.<br />CEL PRACY. Celem podjętych badań była próba znalezienia korelacji między częstością występowania HPV w komórkach osadu moczu a złuszczonymi komórkami nabłonka szyjki macicy w grupie pacjentów z częstym, nawracającym zapaleniem pęcherza.<br />MATERIAŁ I METODY. Obecność wirusa HPV badano zarówno w komórkach osadu moczu, jak również w komórkach nabłonka szyjki macicy u 77 pacjentów.<br />WYNIKI. Analiza osadów moczowych dała łącznie dwadzieścia (25,97%) pozytywnych i 57 (74,03%) negatywnych wyników. Z kolei ocena próbek pochodzących z macicy wykazała 17 dodatnich wyników (22,08%) i 60 (77,92%) negatywnych wyników.<br />WNIOSKI. Przeprowadzone badanie umożliwiło porównanie częstości występowania wirusa HPV w komórkach osadu moczu oraz w komórkach nabłonka szyjki macicy u badanego pacjenta. Przeprowadzone obserwacje prawdopodobnie spowodują dalszą analizę badanego zagadnienia; jednak uzyskane wyniki dostarczają argumentów dla różnych naturalnych procesów infekowania.</p>
Susceptibility of Dermacentor reticulatus tick to repellents containing different active ingrediens
Authors: Gliniewicz A , Borecka A , Przygodzka M , Mikulak E 
Published: May 2019

<p>ABSTRACT</p>
<p>Ticks are vectors of human and animal diseases.<br />MATERIALS AND METHODS. The aim of this study was to investigate the efficacy of four different formulations containing DEET, Icaridin, IR3535 and mix of three compounds: DEET, IR3535 and geraniol, against Dermacentor reticulatus ticks.<br />RESULTS. The repellent effectiveness of these products to adult ticks was different. At 90 minutes after application the repellent A (DEET 30%), repellent D (DEET 30%, IR3535 20%, geraniol 0.1%) and repellent G (IR3535 12%) exhibited a 100% effectiveness in protection against ticks, but the efficacy of repellent C (Icaridin 20%) dropped to 95%.<br />DISCUSSION. DEET is considered by many authors to be the ‘gold’ standard of insect repellents, and we have also confirmed this in our studies with Dermacentor reticulatus. DEET expressed the higher repellency after 7 hours of application (90%) comparing to other formulation - repellent D containing DEET 30%, IR3535 20% and geraniol 0.1%, whose effectiveness dropped to 60%. Repellents C (Icaridin 20%) and G (IR3535 12%) were effective only up to four hours after application (the efficacy was 85% and 40%, respectively).<br />CONCLUSIONS. DEET has proven to be the most effective repellent against Dermacentor reticulatus ticks.</p>
<p>STRESZCZENIE</p>
<p>Kleszcze są przenosicielami wielu chorób ludzi i zwierząt.<br />MATERIAŁ I METODYKA. Celem pracy było określenie działania odstraszającego kleszcze Dermacentor reticulatus czterech produktów zawierających DEET, ikarydynę, IR3535 i mieszaninę 3 substancji: DEET, IR3535 oraz geraniolu.<br />WYNIKI. Skuteczność odstraszania kleszczy przez poszczególne preparaty była różna. Po 90 min po aplikacji repelent A (30% DEET), repelent D (DEET 30%, IR3535 20%, geraniol 0.1%) repelent G (IR3535) wykazywały 100% ochrony przed kleszczami; aktywność repelentu C (Ikarydyna 20%) wynosiła 95%.<br />DYSKUSJA. DEET jest uważany przez wielu autorów za ‘złoty standard’ repelentu dla stawonogów; potwierdzone to zostało również w naszych wynikach dotyczących jego działania na kleszcze Dermacentor reticulatus. Po 7 godzinach od aplikacji repelent zawierający 30% DEET wykazywał 90% odstraszania kleszczy, podczas, gdy aktywność pozostałych formulacji znacząco zmalała: produkt C (zawierający 20% ikarydyny) i produkt G (zawierający 12% IR3535) po 4 godzinach były skuteczne odpowiednio w 85% i 40%.<br />WNIOSKI. Produkt zawierający 30% DEET wykazywał najlepsze właściwości odstraszające w stosunku do kleszczy Dermacentor reticulatus.</p>
PEMANFAATAN METODE TRIPLE EXPONENTIAL SMOOTHING DALAM PERAMALAN PENJUALAN PADA PT.DINAMIKA DAYA SEGARA MALANG
Authors: Tistiawan Tutur Ade , Andini Titania Dwi 
Published: May 2019

PT. Dinamika Daya Segara Malang merupakan salah satu perusahaan yang bergerak di bidang marketing. Dalam hal ini, penjualan produk akan menjadi sorotan utama. Dikarenakan tiap daerah mendapat target baik bulanan maupun per semester dari kantor pusat. Selain itu pada perusahaan ini belum ada sistem yang menunjang untuk peramalan penjualan pada periode berikutnya. Dalam menentukan metode peramalan yang sesuai terlebih dahulu haruslah mengetahui pola data dari data yang akan digunakan sebagai acuan dalam peramalan. Adapun salah satu data penjualan dari PT. Dinamika Daya Segara Malang yaitu sabun Cream detergent Ekonomi / Wings Biru 900K selama periode Januari 2013 sampai April 2016 yang dijadikan objek dalam contoh perhitungan dalam penelitian kali ini. Dari data diperoleh pola data menunjukkan grafik pasang surut. Maka proses peramalan pada jurnal ini menggunakan metode Triple Exponential Smoothing. Adapun dalam proses perhitungan peramalan digunakan konstanta alfa antara 0.1 sampai dengan 0.9. Untuk menghitung nilai kesalahan tiap alfa betujuan untuk mendapatkan nilai kesalahan minimum yang akan digunakan sebagai peramalan terbaik. Berdasarkan hasil akhir peramalan didapatkan nilai Mean Absolute Percentage Error (MAPE) terkecil adalah sebesar 10.04% dengan menggunakan konstanta alfa 0.1 dan hasil peramalan pada bulan Mei 2016 adalah 96.22 box. Selain itu dengan andanya aplikasi yang dibangun diharapkan dapat membantu pihak perusahaan dalam mengetahui hasil ramalan jumlah penjualan di masa akan datang serta dapat membantu dalam menentukan strategi penjualan guna mencapai pada periode berikutnya.
The Relationship between Family Support and the Duration of Labor in Maternity Room of Aura Syifa Hospital Kediri Regency
Authors: Yanuarini Triatmi Andri , Afifah Lupita Nur , Kristianti Shinta 
Published: May 2019

The period of childbirth is one of the indicators in the public health. The Maternal Mortality Rate in Indonesia is still high. One of the causes the high maternal mortality rate is due to the duration of labor. Fear, pain, and anxiety during the labor can interfere with psychological responses that may affect the progress of labor and possibly weaken the strength of mothers. It also causes stress, which leads to the adrenaline expulsion, resulting in narrowing of the blood vessels and reducing the blood flow that carries oxygen to the uterus, so it makes a decrease of uterine contractions that will lead to prolonged delivery time. The attention to psychological problems including involving family participation may affect the labor duration. The aims of this study was to determine the relationship between family support and the duration of labor in maternity mothers in Maternity Room Aura Syifa Hospital Kediri Regency.This research was analytic survey with is cross-sectional research. The population of this study was all maternity mothers in Maternity Room at Aura Syifa Hospital Kediri Regency. 21 Samples were taken and selected by using consecutive sampling technique.Data analysis technique used in this study is Fisher Exact test. The result of the calculation from Fisher Exact test is p = 1> 0,05.H1 is not accepted and H0 is acceptedso it can be concluded that the hypothesis in this study is rejected, in which there is no relationship between family support and the duration of labor.
PENERAPAN TOTAL QUALITY MANAGEMENT PADA ROOM ATTENDANT HOUSEKEEPINGDEPARTEMENT DI HOTEL GRAND Q GORONTALO
Authors: Ali Dhanupoyo Nurhasana Raden 
Published: May 2019

Abstrak:
Industri perhotelan merupakan salah satu industri jasa yang saat ini mulai berkembang di Kota Gorontalo. Perkembangan tersebut menuntut tidak hanya hotel menyediakan produk yang bervariasi tetapi juga didukung oleh kualitas pelayanan. Penelitian ini membahas tentang penerapan Total Quality Management pada housekeeping departemen serta faktor pendukung dan penghambat dalam penerapannya di hotel Grand Q Gorontalo. Penerapan Total Quality Management Housekeeping departemen di di hotel Grand Q Gorontalomemiliki faktor pendukung berupa adanya standar operational procedure (SOP) dari manajemen. Selain itu adanya struktur organisasi yang ramping memudahkan dalam pengawasan dan pemberian pelatihan secara berkala serta hal tersebut juga memberikan manfaat berupa mudahnya komunikasi yang dibangun serta penilaian dalam pemberian penghargaan. Faktor penghambat dalam penerapan total quality management berasal dari faktor eksternal berupa ketersediaan linen bersih dalam menunjang kelancaran operasional dan kelengkapan fasilitas kamar.
HUBUNGAN BUDAYA SEKOLAH DAN KOMITMEN GURU DENGAN MOTIVASI KERJA GURU DI SEKOLAH DASAR NEGERI SE-KOTA SELATAN KOTA GORONTALO
Authors: Kusumi Jeni S. 
Published: May 2019

ABSTRAK
Jeni S.Kumisi.2014. HubunganBudayaSekolah dan Komitmen Guru dalamMotivasiKerja Guru di Sekolah Dasar Negeri Se Kota Selatan Kota Gorontalo. Tesis. Program StudiAdministrasi PendidikanKonsentrasiManajemen PendidikanUniversitas Negeri Gorontalo. Pembimbing:(1) Dr. H. SyamsuQamar Badu, M.Pd (2) Dr. Rosman Ilato, M.PdPenelitianinibertujuanuntukmenganalisisseberapabesarhubunganantara:
1) Budayasekolahdenganmotivasikerja guru Sekolah Dasar Negeri Se Kota Selatan Kota Gorontalo.2) Komitmen guru denganmotivasikerja guru Sekolah Dasar Negeri Se Kota Selatan Kota Gorontalodan3) Budayasekolah dan komitmen guru secarabersama-samadenganmotivasikerja guru Sekolah Dasar Negeri Se Kota Selatan Kota Gorontalo. Penelitianinimerupakanjenispenelitiankuantitatif yang akanmendeskripsikankorelasionalbudayasekolah dan komitmen guru terhadapmotivasikerja guru di Sekolah Dasar Negeri Se Kota Selatan Kota Gorontalo. Adapundesainpenelitianinimelibatkanduavariabelyaituvariabelbebasterdiriatasbudayasekolah (X1) dan komitmen guru (X2) dan variabelterikatyaitumotivasikerja guru (Y). Populasidalampenelitianiniadalahberjumlah 111responden dan memilikisampelsebanyak 53 responden. Teknik pengambilansampeldalampenelitianinimenggunakan teknik menurut Taro Yamane/Slovin.
Sebagaikesimpulan dan temuandaripenelitianiniadalah: 1) Terdapathubungan yang positif dan signifikanbudayasekolahdenganmotivasikerja guru. Dengandemikianapabilabudayasekolahtelahterbentukdenganbaik, makamotivasikerja guru di SD se-Kota Selatan dapatmenjadilebihbaik. 2) Terdapathubungan yang positif dan signifikankomitmen guru denganmotivasikerja guru. Dengandemikianapabilakomitmen gurusudahterpatridenganbaik, makamotivasikerjaGuru di SD se-Kota Selatandapatmenjadilebihbaik. 3) Terdapathubungan yang positif dan signifikanbudayasekolahdan komitmenguru secarasimultandenganmotivasikerja guru.
MENINGKATKAN KETERAMPILAN MENULIS SURAT PRIBADI MELALUI TEKNIK PELATIHAN PADA SISWA KELAS VII A SMP NEGERI 2 MARISA
Authors: Mahadjani Ratna 
Published: May 2019

Abstrak
Permasalahandalampenelitianiniadalahrendahnyakemampuanmenulissuratpribadipadasiswakelas VII A SMP Negeri 2 Marisa. Penelitimelakukanpenelitiantindakandenganmenerapkanteknikpelatihantujuannyaadalahuntukmengatasimasalahtersebut, yaiturendahnyakemampuansiswadalammenulissuratpribadi. Untukitutujuandalampenelitianiniadalahmeningkatkankemampuanmenulissuratpribadimelaluiteknikpelatihan, khususnyakelas VII A SMP Negeri 2 Marisa tahunpelajaran 2016/2017. Metode yang digunakandalampenelitianiniadalahpenelitiantindakankelasmelaluirefleksidiri yang dilakukandalamduasiklus. Setiapsiklusterdiriatasperencanaan, tindakan, observasi, danrefleksi. Hasilpenelitiansetelahdilakukantindakanpembelajaranmelaluiteknikpelatihandiperoleh rata-rata nilaikemampuanmenulissuratpribadipadatindakanSiklus I sebesar 69,55kategoricukupdenganpresentase 45,46 %. Sedangkankemampuanmenulissuratpribadipadatindakan II diperolehnilai rat-rata sebesar 76,36dengankategoribaik, ataumengalamipeningkatansebesar 81,18%. Dari hasilpenelitiantindakankelasinidapatdisimpulkanbahwapenerapanteknikpelatihandapatmeningkatkankemampuanmenulissuratpribadipadasiswakelas VII A SMP Negeri 2 Marisa.