bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Platform trial In COVID-19 vaccine priming and BOOsting (PICOBOO) booster vaccination substudy protocol
Authors: C McLeod , M Dymock , KL Flanagan , M Plebanski , H Marshall , J Marsh , MJ Estcourt , J Ramsay , U Wadia , PCM Williams , MC Tjiam , C Blyth , K Subbarao , S Nicholson , S.N. Faust , RB Thornton , A Mckenzie , T Snelling , P Richmond 
Published: November 2024

Abstract
Background
Coronavirus-2019 (COVID-19) vaccination in Australia commenced in February 2021. The first vaccines recommended for use were AZD1222 and BNT162b2, both delivered as a two-dose primary schedule. In the absence of sustained immunity following immunisation, recommendations for booster vaccination have followed. It is likely that periodic boosting will be necessary for at least some Australians, but it is unknown what the optimal booster vaccines and schedules are or for whom vaccination should be recommended.

Methods
The Platform Trial In COVID-19 priming and BOOsting (PICOBOO) is a multi-site, multi-arm, randomised, Bayesian adaptive platform trial evaluating different booster vaccine interventions in immunocompetent children and adults, stratified by their primary vaccination schedule and age. Participants are randomised to receive one of three licensed COVID-19 booster vaccines available for use in Australia. PICOBOO aims to generate evidence about the immunogenicity, reactogenicity, and cross-protection of different booster vaccine strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants/subvariants. The protocol structure specifying PICOBOO is modular and hierarchical. We have previously published the PICOBOO core (master) protocol. Here, we detail the substudy protocol which outlines the study processes which are specific to PICOBOO participants enrolled in the booster vaccination substudy.

Discussion
PICOBOO is an adaptive platform trial evaluating different COVID-19 booster vaccination strategies to generate evidence to inform immunisation practice and policy. The modular and flexible protocol structure is intended to enable investigators to respond with agility to new research questions as they arise, such as immunogenicity targeting emergent virus variants, and the immunogenicity and reactogenicity of new vaccines as they become available for use.

Trial registration
Australian and New Zealand Clinical Trials Register ACTRN12622000238774; registered on 10/02/2022. Protocol V8.0_23112023.
Bioassay-guided isolation and in Silico characterization of cytotoxic compounds from Hemimycale sp. Sponge targeting A549 lung cancer cells
Authors: Said Asmaa Abo Elgoud , Abdel-Rahman Islam M. , Mostafa Yaser A. , Attia Eman Zekry , Samy Mamdouh Nabil , Abdelmohsen Usama Ramadan , Matsunami Katsuyoshi , Fouad Mostafa A. , Gouda Yaser G. 
Published: November 2024

AbstractBioassay-guided fractionation approach led to identification of two novel compounds; (4-(hydroxymethyl)-3-methoxy-1H-pyrazol (1) and mycalene (2), alongside with four known metabolites; octadecane (3), hexatriacontane (4), 1-heneicosanol (5) and heptatriacontanoic acid (6) from the Red Sea marine sponge Hemimycale sp. The ethyl acetate fraction showed a noticeable cytotoxic activity against the lung cancer cell line (A549) with IC50 value of 75.54 µg/ mL. Structural elucidation was achieved using a combination of 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and high-resolution electrospray ionization-mass spectrometry (HR-ESI-MS). To elucidate the potential mechanism of action behind the cytotoxic effects against lung cancer, a multi-faceted approach combining in silico network pharmacology, experimental validation, and molecular docking studies were employed. Both compounds, designated as 1 and 2, demonstrated significant binding affinities to predicted target proteins, with docking scores of -4.789 and − 4.421 kcal/mol, respectively. These results lay the groundwork for further investigation into the therapeutic potential of these novel compounds from Hemimycale sp. as promising candidates for lung cancer treatment.
Dog ownership, physical activity, loneliness and mental health: a comparison of older adult and younger adult companion animal owners
Authors: Zablan Kirrily , Melvin Glenn , Hayley Alexa 
Published: November 2024

Abstract
Background and aim
Dog ownership has been suggested as an intervention to increase physical activity and improve mental health, but few studies have investigated the relationships between dog ownership, physical activity, and mental health outcomes together. This study aimed to (1) investigate whether dog ownership, CA-related physical activity, and non-CA-related physical activity were explanatory variables for the relationships between CA ownership, depression, and anxiety via loneliness and (2) examine whether the relationships between these variables differed for older adult CA owners compared to younger adult CA owners.

Method
Participants were Australian CA owners from the community (N = 588, 76.3% female) aged 18–84 years (M = 55.34, SD = 14.90). A cross-sectional design and online/phone survey methodology were used.

Results
Path analysis showed that dog owners (compared to owners of other CA types) engaged in higher levels of both CA-related and non-CA-related physical activity, but only non-CA-related physical activity was associated with mental health outcomes. Multigroup moderation analysis showed that older adult and younger adult CA owners experienced similar moderate levels of loneliness, while in younger adults this moderate loneliness was associated with higher levels of depression and anxiety as compared to older adults.

Conclusion
Our findings indicate people who choose to own dogs over other CA types engage in more active lifestyles, but it is the physical activity they perform independently of their dog that is associated with less loneliness and greater mental health. Members of the public should not be universally encouraged by health or other professionals to own a dog to support their mental health based on a belief that dog ownership leads to beneficial physical activity.
Democracy, visa-waivers, and international mobility
Authors: Altundal Ugur , Zarpli Omer 
Published: November 2024

AbstractIn examining visa-waiver agreements, previous studies have primarily focused on economic motivations and effects. In this article, we explore the potential political motivations and consequences. Particularly, we propose that there is a positive relationship between visa-waivers and democracy. We test this using a global dataset that records bilateral travel visa requirements for all countries between 1973 and 2013. We find support for our main hypothesis. We also examine the relationship between democracy, visa waivers and economic development. Contrary to our expectations, we find that democracy continues to exert influence on visa waivers even at high levels of income. Non-democracies fail to attain visa waivers even when they are wealthy. Finally, we explore whether visa waivers could have an impact on individuals’ attitudes towards democracy. Using survey data from 18 Latin American countries, we find suggestive evidence that that visa-waivers can have a positive impact on individuals’ democratic attitudes. Taken together, the findings suggest that democracy and visa-waivers might have a mutually reinforcing relationship.
Revisiting the shuffle of generalized Feistel structure
Authors: Chen Yincen , Guo Yi , Liang Xuanyu , Song Ling , Yang Qianqian 
Published: November 2024

AbstractThe Generalized Feistel Structure ($$\texttt{GFS}$$
GFS
) is one of the most widely used frameworks in symmetric cipher design. In FES 2010, Suzaki and Minematsu strengthened the cryptanalysis security of $$\texttt{GFS}$$
GFS
by searching for shuffles with the best diffusion property. In ASIACRYPT 2018, Shi et al. suggested a set of shuffles, which makes $$\texttt{GFS}$$
GFS
a better resistance against Demirci–Selcuk meet-in-the-middle cryptanalysis. Since these shuffles are different from the currently known good ones and also different from the shuffles used in $$\texttt{TWINE}$$
TWINE
and $$\texttt{LBlock}$$
LBlock
, our research focuses on a more comprehensive evaluation of $$\texttt{GFS}$$
GFS
with different shuffles, including diffusion property of shuffle, differential, linear, impossible differential, zero-correlation linear, integral and Demirci–Selcuk meet-in-the-middle cryptanalysis, to find the best one. Such evaluations entail significant time consumption. Thus, we utilize Mixed Integral Linear Programming models and introduce an evaluate-and-filter strategy to achieve it efficiently. Our results verify that the shuffles discovered by Suzaki and Minematsu and those used in $$\texttt{TWINE}$$
TWINE
and $$\texttt{LBlock}$$
LBlock
are the best so far. We also find that the cryptanalysis resistances of $$\texttt{GFS}$$
GFS
are not necessarily consistent. It is this finding that makes the necessity of our more comprehensive evaluation self-evident.
Surgical outcomes of drug-refractory infantile epileptic spasms syndrome and related prognostic factors: a retrospective study
Authors: Cao Xueyan , Ding Xin , Zhu Fengjun , Chen Li , Chen Yan , Sun Yang , Li Lin , Tan Zeshi , Li Cong , Yao Yi , Su Qiru , Cao Dezhi 
Published: November 2024

Abstract
Background
In this study, we aimed to assess the efficacy of surgical treatment in children with drug-refractory infantile epileptic spasms syndrome (IESS) and examine the factors influencing the post-surgical outcomes.

Methods
The clinical data of 30 children (18 males and 12 females) with epileptic spasms (ES) who underwent surgery at the Epilepsy Center of Shenzhen Children’s Hospital between June 2018 and June 2020 were retrospectively analyzed. Post-surgical outcomes were evaluated using the Engel Epilepsy Surgery Outcome Scale. Scalp electroencephalography and developmental quotient were assessed preoperatively and postoperatively. Univariate analysis and exact logistic regression analyses were used to identify the factors affecting the postoperative efficacy.

Results
Of the 30 patients who underwent surgical resection, 22 (73.3%) achieved Engel’s class I–II outcomes. Additionally, motor and cognitive functions improved in 14 patients (46.7%). The development of 12 (40%) patients remained at the preoperative development level. The median number of antiseizure medications taken preoperatively was 5.27 (range 2–10), which decreased to 1.90 (range 0–4) at the last follow-up. Seizure duration, etiology, positive positron emission tomography-magnetic resonance imaging (PET-MRI), surgery type, and lesion location were significantly correlated with the postoperative efficacy (P < 0.05). Positive PET/MRI findings and lesion location predicted independently the postoperative outcomes. Permanent impairments of motor or language function were rare, with only two cases reporting hydrocephalus and one reporting hemiplegia.

Conclusions
Surgery is an effective treatment option for children with IESS. Early referral and comprehensive preoperative evaluation are essential for identification of surgically treatable structural lesions. The primary surgically treatable cause is cortical malformation, followed by perinatal brain injury. Hemispheric disconnection is a preferred surgical approach. Positive PET/MRI findings and lesion location predicted the postoperative outcomes.
Enhanced detection of Pythium insidiosum via lipid profiling with matrix-assisted laser desorption ionization time of flight mass spectrometry
Authors: Yurayart Nichapat , Jittorntam Paisan , Kumsang Yothin , Rujirawat Thidarat , Jiaranaikulwanich Atisak , Krajaejun Theerapong 
Published: November 2024

AbstractPythiosis is a severe disease in humans and animals globally, caused by the pathogenic oomycete Pythium insidiosum. Early and accurate detection is crucial for effective treatment, but traditional diagnostic methods have limitations. This study presents an alternative approach using Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) for lipid profiling to efficiently identify P. insidiosum. The study involved extracting microbial lipid components using optimized chloroform: methanol biphasic method and creating a lipid profile database with samples from 30 P. insidiosum isolates and 50 various fungi. The methodology was validated on 25 blinded samples for assay detection performance. Unique lipid profiles allowed species-specific identification with high efficiency: scores ≥ 2.682 indicated P. insidiosum, scores ≤ 2.512 suggested fungi, and scores in between pointed to other oomycetes. The assay demonstrated sensitivity, specificity, and accuracy of 100%, 80%, and 88%, respectively, for detecting P. insidiosum. The limited detection specificity was due to false positive samples from closely related Pythium species, which are not a significant clinical concern. The findings show that MALDI-TOF MS lipid profiling can efficiently identify P. insidiosum, offering significant advantages in sample preparation, stability, and reproducibility over protein profile-based methods. This study marks the first instance of lipid profiles being reported for P. insidiosum, paving the way for clinical use in improving accurate detection and facilitating timely treatment interventions.
Insights into the chili phytochemicals, bioactive components, and antioxidant activity of instant premixes (green and red chilies) and their reconstitution products
Authors: Arya Monisha , Kumari Priyanka , Kumar Gyanendra , Chauhan Attar Singh , Giridhar Parvatam 
Published: November 2024

AbstractChili fruits are a potential source of phytochemicals and nutrients for food and reconstituted products. Due to its high nutritional and bioactive components, the current study focused on developing chili instant food products employing hot-air drying method. The effect of the hot-air drying method on physicochemical properties, microbiological quality, retention of bioactive components, phytochemicals, antioxidant properties, and sensory quality of green and red chilies reconstitution products were investigated. HPLC quantification unveiled that fresh red chili product had retained the highest capsaicin (2703.14 µg/g) and dihydrocapsaicin (1518 µg/g) content on the 0th day. Furthermore, UPLC-MS confirmed the presence of eleven phenolic compounds such as gallic acid, chlorogenic acid, caffeic acid, syringic acid, p-coumaric acid, protocatechuic acid, trans-cinnamic acid, ferulic acid, catechin, rutin, and quercetin. Among all, ferulic acid (382.91 µg/g) was the most abundant phenolic compound in fresh green chili products, followed by trans-cinnamic acid (73.19 µg/g) in green chili reconstituted and catechin (65.66 µg/g) in green and red chili reconstituted products. The chili products retained reasonable amounts of bioactive components and antioxidants during storage without microbial growth. The correlation analysis revealed a significant correlation between capsaicinoids, phenolic compounds, and antioxidant properties, which are linearly related in green chili products. This study offers manufacturers a cost-effective technology for producing high-quality chili-reconstituted products rich in essential nutrients and health benefits.
Graphical Abstract
The value of renal color Doppler ultrasound as an objective tool in the diagnosis of renal affection in SLE patients
Authors: Zakarieya Eman Yahya , Reda Mervat Abd Elhamid , Saber Nayera Zaghloul , Nasser Haytham Mohamed , Hammad Ahmed Ibrahim 
Published: November 2024

Abstract
Background
Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse manifestations, which resembles a clinical challenge to be managed. Lupus nephritis is a life-threatening condition as about 10% of patients develop chronic kidney disease.

Aim of the work
To assess the role of resistive index (RI) as a noninvasive parameter in detecting renal affection in SLE patients.

Results
A case–control study included 3 matched groups: 30 patients, 15 SLE with no renal affection, and 15 SLE lupus nephritis patients, who were selected, diagnosed according to ACR criteria 2019 for SLE, beside 15 age- and gender-matched healthy controls without any risk factors of chronic diseases. Written informed consent was obtained from all the three groups, and the study was approved by ethical committee. There was a statistically significant increase in both SLEDAI and renal SLEDAI scores, serum BUN, creatinine, urinary pus cells, RBCs, casts and proteins, 24-h urinary proteins, and protein/creatinine ratio beside a statistically significant increase in both right and left resistive indices in the group of lupus nephritis than the other group. There was highly statistically significant difference between SLE without nephritis and SLE with nephritis regarding renal echogenicity. There was statistically significant positive correlation between average RI and SLEDAI, rSLEDAI, serum creatinine, BUN, 24-h urinary proteins, protein/creatinine ratio, and renal echogenicity. Relation between renal echogenicity and demographic, laboratory, and clinical data was highly statistically significant with rSLEDAI, serum creatinine, BUN, 24-h urinary proteins, and P/C ratio. Our study highlighted that the best cutoff point of Rt average RI to detect SLE with nephritis group was found > 0.68 with sensitivity of 86.7% and specificity of 100.0%, while the best cutoff point of left average RI to detect SLE with nephritis group was found > 0.7 with sensitivity of 80.0% and specificity of 100.0%.

Conclusion
Renal RI is a noninvasive technique that can be used for detection renal disease activity in SLE patients, together with renal parenchymal echogenicity by grayscale US.
Use of Patient-Reported Outcomes in Risk Prediction Model Development to Support Cancer Care Delivery: A Scoping Review
Authors: Paudel Roshan , Dias Samira , Wade Carrie G. , Cronin Christine , Hassett Michael J. 
Published: November 2024

PURPOSE
The integration of patient-reported outcomes (PROs) into electronic health records (EHRs) has enabled systematic collection of symptom data to manage post-treatment symptoms. The use and integration of PRO data into routine care are associated with overall treatment success, adherence, and satisfaction. Clinical trials have demonstrated the prognostic value of PROs including physical function and global health status in predicting survival. It is unknown to what extent routinely collected PRO data are used in the development of risk prediction models (RPMs) in oncology care. The objective of the scoping review is to assess how PROs are used to train risk RPMs to predict patient outcomes in oncology care.

METHODS
Using the scoping review methodology outlined in the Joanna Briggs Institute Manual for Evidence Synthesis, we searched four databases (MEDLINE, CINAHL, Embase, and Web of Science) to locate peer-reviewed oncology articles that used PROs as predictors to train models. Study characteristics including settings, clinical outcomes, and model training, testing, validation, and performance data were extracted for analyses.

RESULTS
Of the 1,254 studies identified, 18 met inclusion criteria. Most studies performed retrospective analyses of prospectively collected PRO data to build prediction models. Post-treatment survival was the most common outcome predicted. Discriminative performance of models trained using PROs was better than models trained without PROs. Most studies did not report model calibration.

CONCLUSION
Systematic collection of PROs in routine practice provides an opportunity to use patient-reported data to develop RPMs. Model performance improves when PROs are used in combination with other comprehensive data sources.
De-naming
Authors: Chang Chia-Hsu Jessica 
Published: November 2024

Abstract
This article analyzes how the colonial naming structure creates and sustains what it means to be human and nonhuman in coloniality. It begins with a preliminary reading of Sylvia Wynter’s interpretation of Frantz Fanon’s “white mask” as a cultural technology, where the modern human’s names lie. The author argues that the “colored skin,” where the dehumanizing names are marked, is the other cultural technology inseparable from the white mask in constituting the colonial naming structure. By understanding skin technology as external to the embodied self, the author investigates how the modern idea of sex also functions as skin technology. The politics of women of color are then explored, interpreting the relation between sex and gender as the “sex-skin/gender-mask structure,” isomorphic to the Fanonian black-skin/white-mask structure. The article further engages with Naifei Ding’s concept of the “feminist knot” to analyze how this structure is reified and reproduced specifically in third-world Taiwan. It concludes with a proposal of “de-naming” as a decolonial methodology to shift away from dehumanizing names that fix a person into their sexed-and-colored skin and toward names that transform their embodied self.
Feminist Development Justice as Emancipatory Praxis
Authors: Mohamed Nasha , Chattopadhyay Sutapa , Gahman Levi 
Published: November 2024

Abstract
This article offers a comprehensive overview of feminist development justice, a transformative framework designed to reduce global inequalities that is being advanced by the Asia Pacific Forum on Women, Law, and Development (APWLD). The piece aims to unsettle and expand mainstream development studies literature, which critical scholars argue remains plagued by Eurocentrism and ongoing colonial modes of knowledge production. Additionally, it advocates for more recognition and citation of the grassroots analysis and frontline praxis of progressive social movements in the Global South that are guided by emancipatory politics and feminist ethics. We begin with a synopsis of development studies’ lack of attention to the enduring consequences of race, colonial power, and imperialism, as well as highlight arguments being made about the radical potential yet qualified merit of knowledges generated by social movements. We then present readers with the concept of feminist development justice, the justice-based pillars on which the framework rests, and the political work of the APWLD. The article ends with a succinct conclusion on what is at stake vis-à-vis extractivism and the seemingly intractable “development” challenges at hand and how grassroots social movements can be rich sources to draw from regarding liberatory change and building better worlds.