bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unexpected link between insect innexins and apoptosis of HeLa cells
Authors: Zhang Wei , Liu Meng‐Wei , Li Ming , Xiao Wei , Zhang Xue‐Wen , He Hao‐Juan , Chen Ya‐Bin , Ding Lei , Luo Kai‐Jun 
Published: June 2018

AbstractLittle is known about how mammalian cells respond to the expression of innexins (Inxs), which are known to mediate cell‐to‐cell communication that causes apoptosis in the cells of the insect Spodoptera litura. The mammalian expression system, p3xFLAG tag protein, containing the CMV promoter, allowed us to construct two C‐terminally elongated innexins (Cte‐Inxs), SpliInx2 (Inx2‐FLAG), and SpliInx3 (Inx3‐FLAG), which were predicted to have the same secondary topological structures as the native SpliInx2 and SpliInx3. Here, we found that only the mRNAs of the two Cte‐Inxs were expressed under the control of the CMV promoter in HeLa cells. Unexpectedly, mRNA expression of the two Cte‐Inxs enhanced apoptosis of HeLa cells. The two Cte‐Inx mRNAs were associated with a significant decrease in Akt phosphorylation in HeLa cells undergoing apoptosis. Furthermore, Inx3‐FLAG mRNA expression in nonapoptotic HCT116 cells was also associated with a significant decrease in the levels of phosphorylated Akt. Intriguingly, expression of the mRNAs of the two Cte‐Inxs did not activate caspase 3, but it markedly reduced Bid levels in HeLa cells undergoing apoptosis. These results suggest that mRNA expression of the two Cte‐Inxs may activate a Bid‐dependent apoptotic pathway in HeLa cells. Our study demonstrates that invertebrate gap junction mRNAs can function in vertebrate cancer cells as tumor suppressors.
Data‐Driven Performance Monitoring for Model Predictive Control Using a mahalanobis distance based overall index
Authors: Xu Yanting , Zhang Guangming , Li Ning , Zhang Jing , Li Shaoyuan , Wang Lu 
Published: June 2018

AbstractThis paper proposes a data‐driven approach for model predictive control (MPC) performance monitoring. It explores the I/O data of the MPC system. First, to evaluate the MPC performance and capture the fluctuation of the process variables, we present an overall performance index based on Mahalanobis distance (MDBI) with its deduced benchmark. The Mahalanobis distance can better characterize the change of the process variable in both principal component space and residual space. As the proper vectors of the two spaces are orthogonal, the MDBI eliminates the correlation between the process variables while considering the variables’ characteristics in both spaces simultaneously, which helps evaluate the MPC performance more effectively with fewer monitoring parameters. Furthermore, for the MPC performance diagnosis, we use the MDBI as inputs and construct a support vector machine (SVM) pattern classifier. The classifier can achieve a higher accuracy when recognizing four common performance degradation patterns and determine the root cause of performance degradation. The results of simulations on the Wood‐Berry distillation column process and experiments on NIAT multifunctional experiment platform illustrate the effectiveness of the proposed performance assessment/diagnosis strategies.
ATPR‐induced G0/G1 phase arrest in gastric cancer cells by regulating the binding of 14‐3‐3ε and filamin A
Authors: Zhao Yingli , Fang Xing , Fang Hui , Feng Yubin , Chen Feihu , Xia Quan 
Published: June 2018

Abstract4‐amino‐2‐trifluoromethyl‐phenyl retinate (ATPR) was able to induce the G0/G1 phase arrest in gastric cancer SGC‐7901 cells by downregulating 14‐3‐3ε. However, the mechanisms underlying this effect have not been fully elucidated. Because 14‐3‐3ε functions as a molecular chaperone on cell cycle regulation, the interaction between 14‐3‐3ε and the target proteins is worth an in‐depth study. In this study, the use of targeting proteomics identified 352 14‐3‐3ε‐binding proteins in SGC‐7901 cells. Analysis of gene ontology (GO) was performed using PANTHER to annotate the biological processes, protein classes, and pathways of these proteins. In 25 cell cycle‐related proteins, filamin A was reduced following ATPR treatment, and this change was validated by immunoprecipitation. The cell cycle was arrested at the G0/G1 phase following ATPR treatment or filamin A silencing in SGC‐7901 cells. Furthermore, subcellular expression analysis showed that 14‐3‐3ε and filamin A were transferred from the cytoplasm to the nucleus after ATPR treatment. On the other hand, overexpression of 14‐3‐3ε, in SGC‐7901 cells, resulted in an increase in the total cellular level of filamin A and an increase in the subcellular localization of filamin A in the cytoplasm. ATPR treatment of the 14‐3‐3ε overexpression cells decreased the total level of filamin A and redistributed filamin A protein from the cytoplasm to the nucleus. Immunohistochemical analysis showed that the expression levels of 14‐3‐3ε and filamin A in gastric cancer tissues were significantly higher, with a predominant localization in the cytoplasm, compared to the levels in matched tissues. Taken together, our results suggest that ATPR can induce nuclear localization of filamin A by reducing the binding of 14‐3‐3ε and filamin A, which may be the mechanism of ATPR‐induced G0/G1 phase arrest.
Electron Flow in Large Metallomacromolecules and Electronic Switching of Nanoparticle Stabilization: Click Ferrocenyl Dentromers that Reduce AuIII to Au Nanoparticles
Authors: Wang Qi , Fu Fangyu , Martinez‐Villacorta Angel M. , Moya Sergio , Salmon Lionel , Vax Amélie , Hunel Julien , Ruiz Jaime , Astruc Didier 
Published: June 2018

AbstractClick ferrocenyl‐terminal dentromers, a family of arene‐cored dendrimers with triple branching (9‐Fc, 27‐Fc, 81‐Fc, and 243‐Fc), reduce AuIII to ferricinium dentromer‐stabilized Au nanoparticles (AuNPs). Cyclic voltammetry studies in CH2Cl2 show reversible CV waves with some adsorption for the 243‐Fc dentromer and the number of redox groups found, 255±25, by using the Bard–Anson method, is close to the theoretical number of 243. The dentromers reduce aqueous HAuCl4 to water‐soluble ferricinium chloride dentromer‐stabilized AuNPs with core sizes between 30 and 47 nm. These triazolylferricinium dentromer‐stabilized AuNPs are reduced by cobaltocene to cobalticinium chloride and ferrocene dentromer weakly stabilized AuNPs together with a redshift of the AuNP plasmon. The weakness of the AuNP stabilization is characterized by dentromer extraction with CH2Cl2 along with irreversible AuNP agglomeration for the 9, 27, and 81‐ferrocenyl dentromer, with only the 243‐ferrocenyl dentromer‐AuNP withstanding this process. Altogether, this demonstrates the electronic switching of the dentromer‐mediated AuNP stabilization.
From LiB3O5 to NaRbB6O9F2: Fluorine‐Directed Evolution of Structural Chemistry
Authors: Han Shujuan , Zhang Bingbing , Yang Zhihua , Pan Shilie 
Published: June 2018

AbstractIntroducing fluorine into borates indicates the direction for structural evolution. A new fluorooxoborate, NaRbB6O9F2 featuring a unique [B6O9F2]∞ layered structure and excellent optical properties has been synthesized. It is further demonstrated that incorporation of fluorine can enrich the structural chemistry of borates.
Exploring Active Sites in Multi‐Heteroatom‐Doped Co‐Based Catalysts for Hydrogen Evolution Reactions
Authors: Shahraei Ali , Martinaiou Ioanna , Creutz K. Alexander , Kübler Markus , Weidler Natascha , Ranecky Simon T. , Wallace W. David Z. , Nowroozi Mohammad Ali , Clemens Oliver , Stark Robert W. , Kramm Ulrike I. 
Published: June 2018

AbstractToday, metal–N‐ as well as metal–S‐doped carbon materials are known to catalyze the hydrogen evolution reaction (HER). However, especially N‐ and S‐co‐doped catalysts reach highest activity, but it remains unclear if the activity is related to MNx or MSy (M=metal) sites. In this work we apply a simple method for multi‐heteroatom doping and investigate the effect of cobalt content on the HER in acidic medium. The CoNx and CoSy sites were evidenced on the basis of structural characterization by Raman, X‐ray induced photoelectron spectroscopy, and TEM. The presence of sulfur enables the formation of a larger number of CoNx sites. Structure–performance relationship proves that the HER activity is dominated by CoNx rather than CoSy sites. The most active catalysts also exhibit an excellent stability under galvanostatic conditions making them of interest for electrolyser application.
Atropisomerism in Rilpivirine hydrochloride: Spectroscopic characterization of Rilpivirine and related impurities
Authors: Natarajan Senthilkumar , Salmara Ganeshbhat Hiriyanna , Shrivastava Sujeet , Sankareswaran Srimurugan , Kumar Pramod 
Published: June 2018

AbstractNuclear magnetic resonance (NMR) technique has been used to find the property of atropisomerism in Rilpivirine hydrochloride by variable temperature analysis and various 2D techniques. Both the Rilpivirine hydrochloride (E‐isomer) and Impurity‐A (Z‐isomer) isomers have been differentiated and confirmed by NMR and ultraviolet techniques. Preparative high‐performance liquid chromatography isolation for Impurity‐A is followed by spectroscopic (NMR, mass spectra, and infrared) investigation that provides a perfect solution for determination of the structure of Rilpivirine and related impurities.
Synthesis of Substituted Naphthalenes by 1,4‐Palladium Migration Involved Annulation with Internal Alkynes
Authors: Wei Dong , Hu Tian‐Jiao , Feng Chen‐Guo , Lin Guo‐Qiang 
Published: June 2018

AbstractThe palladium catalyzed annulation of 1‐bromo‐2‐vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4‐palladium migration process is the key for success.
Fluorescein‐Loaded Solid Lipid Nanoparticles Based on Monoamine Pillar[5]arene: Synthesis and Interaction with DNA
Authors: Yakimova L. S. , Shurpik D. N. , Guralnik E. G. , Evtugyn V. G. , Osin Y. N. , Stoikov I. I. 
Published: June 2018

AbstractPresent research is the first example to use pillar[5]arene for creation fluorescein‐loaded solid lipid nanoparticles and release dye during interaction with DNA ‐ potential delivery system of the imaging agent. Monoamine functionalized pillar[5]arene was synthesized for preparation of the solid lipid nanoparticles (SLN) with/without luminescent marker (fluorescein). Interestingly, presence of a single tail‐group in the pillar[5]arene has opened wide opportunities for the formation of the various types of pillararene‐based assemblies, i. e., pseudorotaxanes, supramolecular polymers and SLNs, varying the solvents.
Favourable outcomes for childhood acute lymphoblastic leukaemia in an isolated setting: The Tasmanian experience
Authors: Heath John A. , Macdonald Molly , Starosta Helen , Hitchins Samuel , Wills Karen , Daubenton John D. 
Published: June 2018

AbstractBackgroundTasmania is a large, relatively isolated island located south of mainland Australia with limited tertiary level paediatric oncology services.AimsTo benchmark regional outcomes for childhood acute lymphoblastic leukaemia (ALL) against published international standards.MethodsWe undertook a retrospective cohort study, analysing the clinical characteristics and health outcomes of all children diagnosed with and treated for ALL in Tasmania, Australia between 2006 and 2015.ResultsThirty‐five patients aged less than 18 years were diagnosed with ALL in the study's 10‐year period. Twenty‐eight cases were precursor B cell in origin, with 7 cases of T‐cell ALL. The great majority of children (30/35; 86%) received their entire first line treatment in Tasmania. Major treatment‐related toxicities, including allergic drug reactions, and episodes of acute pancreatitis, deep venous thrombosis and bacterial sepsis, were managed locally, with one death secondary to overwhelming infection and multiorgan failure. The overall and event‐free survival rates for childhood ALL were 30/35 (86%) and 28/35 (80%), respectively.ConclusionsThese results compare favourably with published results from large international cooperative group trials based in developed countries. Continued local treatment with appropriate support from a dedicated specialist paediatric oncology unit is therefore justified.
A Self‐Supported λ‐MnO2 Film Electrode used for Electrochemical Lithium Recovery from Brines
Authors: Xu Xin , Zhou You , Feng Zhiwen , Kahn Naeem Ullah , Haq Khan Zia Ul , Tang Yang , Sun Yanzhi , Wan Pingyu , Chen Yongmei , Fan Maohong 
Published: June 2018

AbstractLithium recovery from an aqueous resource was accelerated by electrochemically driving the transformation of MnIV/MnIII with a spinel λ‐MnO2 film electrode. A λ‐MnO2 electrode without binders or conductive additives is preferred for achieving a large capacity at high current density and long‐term cycling capability. In this study, a film of Mn(OH)2 was first deposited on the surface of Pt or graphite substrates owing to alkalization near the cathode, then it was oxidized to a Mn3O4 film by air, followed by being hydrothermally lithiated to LiMn2O4 spinel and, finally, it was turned into the λ‐MnO2 film electrode through potentiostatic delithiation. The results show that the charging/discharging electric capacity of the fabricated λ‐MnO2 film electrode was up to ≈100 mAh g−1 at a current density of 50 mA g−1 in 30 mm Li+ aqueous solution, twice that of the λ‐MnO2 powder electrode. Also, 82.3 % lithium capacity remained after 100 cycles of an electrochemically assisted lithium recovery process, indicating high availability and good stability of the λ‐MnO2 spinel on the electrode. The energy consumption for each cycle is estimated to be approximately 1.55±0.09 J, implying that only 4.14 Wh is required for recovery of one mole of lithium ions by this method.
Clicking Biobased Polyphenols: A Sustainable Platform for Aromatic Polymeric Materials
Authors: Buono Pietro , Duval Antoine , Avérous Luc , Habibi Youssef 
Published: June 2018

AbstractLignin, tannins, and cashew nut shell liquid are considered the main sources of aromatic‐based macromolecules. They represent an abundant alternative feedstock for the elaboration of aromatic chemicals and polymers, with a view to replacing some fossil‐based fractions. Located in different tissues of plants, these compounds, with a large diversity and structural complexity, have, to date, been considered as byproducts derived from fractionation–separation industrial processes with low added value. In the last decade, the use of click chemistry as a tool for the synthesis of controlled macromolecular architectures has seen much development in fundamental and applied research for a wide range of applications. It could represent a valid solution to overcome the main limitations encountered in the chemical modification of natural sources of chemicals, with an environmentally friendly approach to create new substrates for the development of innovative polymers and materials. After a brief description of the main aromatic biopolymers, including the main extraction techniques, along with their structure and their properties, this Review describes chemical modifications that have mainly been focused on natural polyphenols, with the aim of introducing clickable groups, and their further use for the synthesis of biobased materials and additives. Special emphasis is given to several as‐yet unexplored chemical features that could contribute to further fundamental and applied materials science research.
Study of atmospheric attenuation characteristics of terahertz wave based on line‐by‐line integration
Authors: Jing Qingfeng , Liu Danmei 
Published: June 2018

SummaryTerahertz band communication promises new solution for satisfying the increasing demand for ultrahigh‐speed wireless communication. Channel models capturing the unique peculiarities of the terahertz (THz) band are required for communication systems designing. Extreme high molecular absorption is a distinctive phenomenon that has to be involved in terahertz communication models. Research in this field has mainly focused on the characteristics along the horizontal propagation path. In this paper, we developed a unified molecular absorption model along the slant propagation path of the THz wave, based on the line‐by‐line integration method developed by Van‐Vleck and Weisskopf and combining the molecular spectral line in the HITRAN database. Then, an in‐depth analysis on the THz channel characteristics is carried out by the developed propagation models. The attenuation characteristics of terahertz waves with frequencies in the range of 0.1 to 1 THz are analyzed by theoretical and mathematical modeling. The results show that the terahertz communication channel has a strong dependence on both the molecular composition of the medium and the transmission distance. The experimental results also indicate the strong absorption frequency points, weak absorption frequency points, and spectral windows.
Climatic adaptation and ecological descriptors of wild beans from Mexico
Authors: Cerda‐Hurtado Ivon M. , Mayek‐Pérez Netzahualcoyotl , Hernández‐Delgado Sanjuana , Muruaga‐Martínez José S. , Reyes‐Lara Martín A. , Reyes‐Valdés Manuel Humberto , González‐Prieto Juan M. 
Published: June 2018

AbstractDespite its economic, social, biological, and cultural importance, wild forms of the genus Phaseolus are not well represented in germplasm banks, and they are at great risk due to changes in land use as well as climate change. To improve our understanding of the potential geographical distribution of wild beans (Phaseolus spp.) from Mexico and support in situ and ex situ conservation programs, we determined the climatic adaptation ranges of 29 species and two subspecies of Phaseolus collected throughout Mexico. Based on five biotic and 117 abiotic variables obtained from different databases—WorldClim, Global‐Aridity, and Global‐PET—we performed principal component and cluster analyses. Germplasm was distributed among 12 climatic types from a possible 28. The general climatic ranges were as follows: 8–3,083 m above sea level; 12.07–26.96°C annual mean temperature; 10.33–202.68 mm annual precipitation; 9.33–16.56 W/m2 of net radiation; 11.68–14.23 hr photoperiod; 0.06–1.57 aridity index; and 10–1,728 mm/month of annual potential evapotranspiration. Most descriptive variables (25) clustered species into two groups: One included germplasm from semihot climates, and the other included germplasm from temperate climates. Species clustering showed 45% to 54% coincidence with species previously grouped using molecular data. The species P. filiformis, P. purpusii, and P. maculatus were found at low‐humidity locations; these species could be used to improve our understanding of the extreme aridity adaptation mechanisms used by wild beans to avoid or tolerate climate change as well as to introgress favorable alleles into new cultivars adapted to hot, dry environments.
Do adult trees increase conspecific juvenile resilience to recurrent droughts? Implications for forest regeneration
Authors: Andivia Enrique , Madrigal‐González Jaime , Villar‐Salvador Pedro , Zavala Miguel A. 
Published: June 2018

AbstractRecruitment is a bottleneck for forest regeneration especially in semi‐arid Mediterranean environments. Ensuring natural forest regeneration is vital for preserving ecosystem function under climate warming and increased frequency and intensity of extreme droughts. Interspecific positive interactions are of paramount importance in these ecosystems. The net outcome of conspecific plant interactions in semi‐arid forests, however, has been less explored, particularly the range of environmental conditions for which juveniles benefit from nursing effects. We evaluated the direction and magnitude of intraspecific relationships between adults and juveniles ofPinus pinasterin a dry continental Mediterranean forest in the Iberian Peninsula. We measured the longitudinal shoot elongation of the last 15 yr and foliar functional traits in pine saplings growing under the canopy of adult pines and in open habitats. We examined the growth response to precipitation and the resilience and resistance of growth to two extreme drought events in 2005 and 2012. Our results show likely facilitation of saplings by adult conspecifics. Nursed saplings had a greater size relative to age, longer needles, and faster shoot elongation than saplings in open habitats. In addition, saplings under the canopy were more resistant and resilient to the first severe drought event. However, saplings grown in open habitats were more resilient to the second drought event, which might suggest a shift in the net balance of conspecific interactions with increased drought frequency and with tree ontogeny. These results have a direct application for the adaptation and restoration of semi‐arid forest ecosystems under climate change. Currently, adults are used as nurse plants to enhance survival and growth of juveniles. However, this positive effect on sapling performance might shift to negative under scenarios of increasing frequency and intensity of drought events.
Single‐walled Carbon Nanotube‐Calixarene Based Chemiresistor for Volatile Organic Compounds
Authors: Sarkar Tapan , Srinives Sira , Rodriquez Armando , Mulchandani Ashok 
Published: June 2018

AbstractCalixarenes are exciting class of organic macromolecules and proved to be an excellent sensing material for optical and mass transaction based sensors. The limited conductivity of calixarenes is a major impediment for the development of calixarene‐only chemiresistive sensors. The authors report on a calixarene‐based chemiresistor that is based on a hybrid material obtained by non‐covalent functionalization of SWCNTs with calixarene. This has two beneficial effects: (a) The use of SWCNT eliminates the conductivity issue, and this enables low‐power chemiresistive sensing; (b) the excellent affinity of calixarenes for certain analytes improves sensitivity. The hybrid material was fabricated by solvent casting, and its formation was confirmed by structural (SEM and TEM), electrical (ID−VD and ID−VG), and spectroscopic (Raman and ATR‐IR) characterizations. The resulting sensing device, operated typically at +1 V, undergoes an increase in resistance upon exposure to successive increments in concentration from 50 to 250 ppm for benzene, toluene, ethylbenzene and xylenes, commonly known as BTEX. Respective limits of detection are 25, 7.5, 6.5, and 4 ppm. This is well below their Occupational Safety and Health Administration (OSHA) permissible exposure limit (PEL) except for benzene. A mechanistic study for BTEX was performed via field‐effect transistor measurements, and this suggested that the sensing mechanism is dominated by an electrostatic gating effect. In our perception, the availability of a wide variety of calixarenes generates wide perspectives for calixarene‐only based SWCNT‐calixarene hybrid sensor arrays for the realization of electronic nose application.