bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fictional Expectations and the Global Media in the Greek Debt Crisis: A Topic Modeling Approach
Authors: Daniel Volker , Neubert Magnus , Orban Agnes 
Published: January 2019

Abstract
We study the role of global media during the Greek debt crisis and relate it to the transmission of events on financial actors’ expectations. To identify news coverage about the Greek debt crisis, we apply topic modeling to a newly compiled dataset of over 430,000 articles from The International New York Times and Financial Times from 2009 to 2015. We identify a Greek debt crisis topic and relate it to events concerning Greece during this time period. Our finding is that events are only relevant for financial markets when they are covered in the media, whereas events without media coverage have no effect. News coverage without immediate events is equally irrelevant for financial markets.
Perceived barriers to diabetes management at home: a qualitative study
Authors: Açıl Dilay , Bahar Zuhal 
Published: January 2019

Abstract

Background
Diabetes is a complex and progressive disease and its treatment requires self-management strategies specific for each patient. The aim of the study was to determine perceived barriers to diabetes management at home in type II diabetes patients.

Materials and methods
Inclusion criteria of this phenomenological study included living in İzmir and a diagnosis for the last 1 year; 15 patients with diabetes participated the study. A semi-structured interview form based on Health Belief Model created by researchers with experts opinion, was used at in-depth face-to-face interviews. Data were analyzed with content analysis. Ethical and hospital approval was obtained. Participation of individuals is based on volunteerism; written informed consent from patients who accepted the study.

Results
Perceived barriers to fulfilling home care needs and sustaining behavior of diabetes management included six themes, i.e. insufficient knowledge of diabetes, inability to accept diabetes, non-adherence to diabetes and exercise, problems with health care services, fear and effects of the family and the society and relevant subthemes.

Conclusion
These findings about the barriers of the patients should provide guidance for patient specific nursing interventions.
Synthesis of 2,6-dimethoxy-9-phenyl-1H-phenalen-1-one and structural revision of the benzoindenone from Eichhornia crassipes
Authors: Li Xiaowan , Si Tongxu , Ku Chuenfai , Zhang Hongjie , Wang Mingzhong , Chan Albert S.C. 
Published: January 2019

Abstract
The total synthesis of the natural phytoalexin 2,6-dimethoxy-9-phenyl-1H-phenalen-1-one (3) isolated from Eichhornia crassipes was accomplished in seven steps. The synthetic strategy included a Friedel–Crafts acylation and a Jacobsen–Katsuki epoxidation as the key reactions to obtain the target compound. Based on a comparison of the NMR data and a crystal structure of 3, the previously proposed structure of 2,5-dimethoxy-4-phenyl-benzoindenone (2) isolated from the same plant has been revised.
Communism as a Spiritual Attack on Man
Authors: Zwoliński Andrzej 
Published: January 2019

Marxist ideology, and later the practice of the communist state, denied the essential goals of education, making it an important tool for indoctrination. Man ceased to be the highest value, and was replaced by other values that were lower than him.The communist program of raising children and youth in atheism, without God, was an attack on all believers, because it impacted the future of any religion in Russia.The pontificate of John Paul II, the first Pope from a communist country, was important in determining the threat of Marxism. In the encyclical „Laborem Exercens” the Pope stated that “by the use of various kinds of influence, including revolutionary pressure, it aims to win a monopoly of power in each society.” (LE, 11). The fundamental assessment of Marxism was made by John Paul II in response to social issues posed by the so-called theology of liberation. This power reaches deep and is vast, because it affects the whole person, in all dimensions of his existence.
The Personalist Vision of Marriage in the Context of its Contemporary Depreciation
Authors: Krępa Magdalena 
Published: January 2019

This paper presents the personalist vision of marriage referring mostly to Christian teaching on marriage and family. The post-modern society highlights a very critical assessment of the institution of marriage, supporting an individual rather than marital life. In such a situation the Catholic teaching on marriage, and ethos of marriage, is more and more challenged even by Christians, especially in the area of moral decision and life practice. In response to post-modern challenges, Christian personalism refers to the truth about the vocation of man to fulfil their humanity in corporality-determined sexuality. It is not only about anatomic differences but about a different manner of being man in many spheres. Christian reflection, unchangeable as to the assessment of the character of the relationship between a man and a woman, first and foremost refers to a thesis about both the distinctness and complementarity of sexes, embedded in the very human nature. Christian teaching identifies marital love only with the form of the commitment of the person who loves, in their own dynamics, to the good of the person loved. Complete love is directed towards a physical, mental and spiritual union with the loved person and develops from sensuality, through the mental and cultural sphere, to the spiritual domain. A Catholic apprehension of marriage does not question its natural character but defends it, and at the same time shows a radical change that takes place between a man and a woman through the sacramental virtue. Marriage is a deep union and covenant based on love rooted in God remaining the source of Love.
Consequences of Childhood Sexual Abuse for Intimate Couple Relationship according to Relational Marital Therapy
Authors: Jerebic Sara , Jerebic Drago 
Published: January 2019

Childhood sexual abuse is a traumatic experience, the consequences of which are numerous in adult intimate relationships. Couples often have problems in maintaining their relationships and frequently face problems in their sexual life. Because of the consequences that they experience and which they usually do not attribute to past trauma, couples increasingly seek therapeutic help. A safe therapeutic relationship enables the formation of new neural connections and a change in relational structures. Identifying and understanding the consequences of sexual abuse with elements of dual awareness is essential for the partnership and healing of both partners. The purpose of the article is to deepen the understanding of the consequences of childhood sexual abuse for couple relationships according to the Relational Marital Therapy paradigm.
Anthropology of the evangelical counsels in the school of St. Benedict of Nursia
Authors: Tupikowski Jerzy 
Published: January 2019

Man is someone real and as such he is immersed in a world that is a task set to him as a person. Therefore, the whole world, as entirely coming from God, and entirely assigned to Him, is constantly bursting with its natural truth and good and, consequently, also beauty. This is an important perspective, both in the order of nature and in the order of grace, also because the synthesis and fulfilment of all values (perfections), which is personal fullness – holiness, is the ultimate reference of the human person to the Person of God. However, this perspective becomes comprehensible only in the field of the realism of the human person’s truth, goodness and beauty, related to their perfect Source, and therefore to the Truth, Goodness and Beauty of the Person of God Himself.In this sense, it can be said that God is the End of all perfections. Holiness itself is thus a specific peak of the elevation of human potentialities to a higher level of being. „Holiness, through the elevation of truth, goodness and beauty to the supernatural level, can fulfil the potential of human nature – reason and will, to their limits; and this fulfilment, in Christian thought, can only take place in visio beatifica, to which this life here and now is supposed to prepare us”. Let us add that the understanding and implementation of evangelical counsels: chastity, poverty and obedience, serve this growth in a particular way. The counsels are the evangelical factor stimulating and strengthening the work of the intellect and free will.
Kościół o możliwościach techniki
Authors: Zwoliński Andrzej 
Published: January 2019

Kościół o możliwościach techniki. W kontekście rozwoju nowych technologii Kościół wskazuje na potrzebę odkrywania prawdy o człowieku i jego roli w świecie technologii. W analizach techniki współczesnej już dawno rozróżniano tzw. technikę służebną i technikę prometejską. W tym ujęciu techniki zawiera się pewna dwoistość jej rozumienia. W nowych rozwiązaniach technicznych może bowiem kryć się zamach na miejsce człowieka w świecie, bunt przeciw prawom Bożym albo też służebne korzystanie z darów Bożych, zgodnie z zamysłem i planem Boga. Krytyka transhumanizmu sprowadza się do zastrzeżeń co do możliwości osiągnięcia wyznaczonych celów oraz zastrzeżeń natury etycznej. Są to zarzuty natury ogólnej, wysuwane od dawna wobec spontanicznego rozwoju techniki i nowych technologii.
Rola cudu w apologetyce przed II soborem watykańskim. Refleksja na podstawie analizy ówczesnych podręczników akademickich
Authors: Plata Łukasz 
Published: January 2019

W niniejszym artykule autor podjął refleksję nad tym, jaka była rola cudu w wykładzie podręcznikowym apologetyki przed Vaticanum II. Szukając odpowiedzi na to pytanie, najpierw przedstawił nauczanie I Soboru Watykańskiego na temat cudu i jego roli. Następnie poddał analizie kilka polskojęzycznych podręczników akademickich do apologetyki, jakie pojawiły się przed II soborem watykańskim, aby zbadać w nich funkcję cudu w relacji do Objawienia.
IL-34–Dependent Intrarenal and Systemic Mechanisms Promote Lupus Nephritis in MRL-Faslpr Mice
Authors: Wada Yukihiro , Gonzalez-Sanchez Hilda M. , Weinmann-Menke Julia , Iwata Yasunori , Ajay Amrendra K. , Meineck Myriam , Kelley Vicki R. 
Published: January 2019

Significance Statement
Macrophages and autoantibodies play a central role in the pathology of lupus nephritis in patients with lupus and in the MRL-Faslpr
mouse model. The authors demonstrate that IL-34 and its two receptors, cFMS and PTPRZ, are upregulated in the kidney with advancing nephritis in MRL-Faslpr
mice. Genetically deleting IL-34 in these mice suppresses nephritis and the systemic illness via macrophage- and autoantibody-mediated mechanisms within and outside of the kidney. The authors also found that patients with lupus nephritis have elevated IL-34 in serum and urine; intrarenal and systemic expression of IL-34, cFMS, and PTPRZ similar to that displayed in MRL-Faslpr
mice; and IL-34 expression that correlates with histopathologic index of disease activity. These findings suggest that IL-34 is a promising novel therapeutic target for patients with lupus nephritis.

Background
In people with SLE and in the MRL-Faslpr
lupus mouse model, macrophages and autoantibodies are central to lupus nephritis. IL-34 mediates macrophage survival and proliferation, is expressed by tubular epithelial cells (TECs), and binds to the cFMS receptor on macrophages and to a newly identified second receptor, PTPRZ.

Methods
To investigate whether IL-34–dependent intrarenal and systemic mechanisms promote lupus nephritis, we compared lupus nephritis and systemic illness in MRL-Faslpr
mice expressing IL-34 and IL-34 knockout (KO) MRL-Faslpr
mice. We also assessed expression of IL-34 and the cFMS and PTPRZ receptors in patients with lupus nephritis.

Results
Intrarenal IL-34 and its two receptors increase during lupus nephritis in MRL-Faslpr
mice. In knockout mice lacking IL-34, nephritis and systemic illness are suppressed. IL-34 fosters intrarenal macrophage accumulation via monocyte proliferation in bone marrow (which increases circulating monocytes that are recruited by chemokines into the kidney) and via intrarenal macrophage proliferation. This accumulation leads to macrophage-mediated TEC apoptosis. We also found suppression of circulating autoantibodies and glomerular antibody deposits in the knockout mice. This is consistent with fewer activated and proliferating intrarenal and splenic B cells in mice lacking IL-34, and with our novel discovery that PTPRZ is expressed by macrophages, B and T cells. These findings appear translatable to human patients with lupus nephritis, whose expression of IL-34, cFMS, and PTPRZ is similar to that seen in the MRL-Faslpr
lupus mouse model. Moreover, expression of IL-34 in TECs correlates with disease activity.

Conclusions
IL-34 is a promising novel therapeutic target for patients with lupus nephritis.
Digitalisasi Penyiaran Televisi di Indonesia
Authors: Gultom Amry Daulat 
Published: January 2019

Penelitian ini dilakukan untuk memperoleh gambaran terkait status dan tantangan peralihan penyiaran digital di Indonesia. Penelitian ini menggunakan pendekatan kualitatif dan studi literatur. Hasil penelitian menunjukkan bahwa Indonesia menghadapi beberapa tantangan di sisi regulasi, yaitu UU Penyiaran saat ini yang belum mengatur penyiaran digital secara spesifik dan permasalahan hukum terkait regulasi penyiaran digital yang berdampak tenggat waktu peralihan dari analog ke penyiaran televisi digital tahun 2018 tidak dapat dipenuhi*****This study was conducted to gather an overview of the current status and challenges of digital broadcasting in Indonesia. This study uses qualitative approach and literature studies. The results show that Indonesia faces several challenges on the regulatory side, namely the existing Broadcasting Act that has not regulated specific digital broadcasting and legal issues related to digital broadcasting regulation delayed the transition deadline from analog to digital television broadcasting in 2018
A TREM2 dependent control of Microglial and Astrocytic responses in a mouse model of Alzheimer's Disease
Authors: Achebe Nnamdi , Puntambekar, Ph.D Shweta S. , Lamb Bruce T. 
Published: January 2019

Background and Hypothesis:
Alzheimer’s Disease (AD) is characterized by deposition of extracellular amyloid beta plaques resulting in activation of plaque associated CNS glial cells, namely microglia and astrocytes. While extensive research has been directed to understand the role of microglia in neurodegenerative changes in AD, relatively little is known of astrocytic contributions to the disease. Studies using nerve injury models have shown that pro-inflammatory microglia can induce neurotoxic astrocytic phenotypes. In AD, the microglial gene TREM2 has been implicated in mediating neuroprotective immune functions. Research suggests that microglia go through TREM2-independent, followed by TREM2-dependent activation to mediate neuroprotection in diseases like AD, ALS and PD. The central objective of this project is to evaluate whether TREM2 dependent skewing of microglial activation generates neuro-protective/toxic astroglial populations.
Experimental Design or Project Methods:
We will use the 5XFAD mouse model of AD in this project. Changes in microglial and astroglial activation will be evaluated in 4-month-old 5xFAD; TREM2+/-mice using immunofluorescence and confocal microscopy
Results:
Our results show an increase in proinflammatory, plaque associated microglia expressing MHCII and C1qA in 5XFAD;TREM2+/- mice relative to 5XFAD;TREM2+/+ mice. This is accompanied by an increase in GFAP+S100B- reactive astrocytes in the hippocampus and subiculum.
Conclusion and Potential Impact:
TREM2 deficiency in a mouse model of AD skews the microglia to a proinflammatory phenotype, which may correlate with heightened astroglial reactivity and neurotoxicity. As loss of function mutations in TREM2 have been associated with an increased risk of neurodegenerative changes, these data shed light on how TREM2-mediated microglial-astrocytic crosstalk may influence disease progression.
Effects of Propofol on Transcytosis in an IPSC Derived Blood Brain Barrier Model
Authors: Bieber Dylan , Hughes Jason , Neese Olivia , Canfield Scott Canfield G. 
Published: January 2019

Background: In 2016, the FDA released a report concerning the use of anesthetics in young children and pregnant women. This report states that prolonged or repeat exposure to anesthetic may lead to neurodevelopmental delay. Previously, Canfield et al., had determined a method for developing a human blood brain barrier model from induced pluripotent stem cells (iPSC). Preliminary data has shown that exposing this model to propofol at relevant concentrations significantly reduces barrier strength and may promote leakiness of the blood brain barrier.
Design/Methods: Our efforts during these ten weeks focused on the effects of propofol on transcellular mechanisms in iPSC-derived brain microvasculature endothelial cells (BMEC). After exposing to propofol, fluorescently labeled dextran transcytosis and accumulation was analyzed on a fluorescent plate reader. Specifically, we monitored the transcellular movement of different molecular weighted dextrans.
Results: Treatment of BMECs with 50uM propofol increased transcytosis and accumulation of 10kDa dextran as compared to control. Increased transcytosis in the absence of increased accumulation of 3kDa dextran may provide evidence of paracellular transport. Transcytosis and accumulation of 40kDa dextran were unchanged between treatment and control groups. These data may provide evidence that propofol affects transcytosis mechanisms differently.
Potential Impact: We hope to more fully understand the mechanism by which anesthetics such as propofol effect the blood brain barrier. Due to the presence of tight junction proteins, transcytosis is an important mechanism for moving materials into the brain parenchyma. Further research will need to be done to determine the mechanism by which propofol affects BMEC transcytosis.
Forever-Fit Summer Camp
Authors: Boateng, BA Anthony O. , Yazel-Smith, MS, MCHES CCRP Lisa , McKinney, BS Brett , Haberlin, MPH, CHES Katie , Hannon, MD, MS Tamara , Perry, MPH Patrick 
Published: January 2019

Background and Hypothesis:
The objective of this study was to evaluate anthropometric and physical fitness measures from participants in the Forever-Fit Summer Camp (FFSC) between the years 2013 and 2017, comparing baseline and post-participation values. We hypothesized that participation in the FFSC would decrease the BMI Z-score of the campers during the 6-week program, as well as improve physical fitness measures. Further, we hypothesized that there would be an overall decrease in BMI and weight seen in campers who participated for multiple years.
Experimental Design:
In this 5-year cross-sectional evaluation, a total of 64 participants were included. During FFSC, biometrics, strength, endurance and flexibility were compared at baseline (Week 1) and 6 weeks after. This data from participants was compared using paired T-tests and compared the BMI Z-Score of campers over the years using repeated measures ANOVA.
Results:
Compared to baseline for each year, there was an overall decrease in BMI Z-Score and weight after the 6-week intervention. We observed an increase in strength and endurance, as seen with the 1-mile run and various strength test. Interestingly, we saw a decrease in flexibility in the campers as they progressed through the camp. Further, we observed an overall decrease in BMI Z-Score from 2013 to 2017.
Conclusion and Potential Impact:
The FFSC 6-week summer program had significantly decreased BMI and improved fitness measures. The activities performed in the FFSC could be implemented in other programs for youth to combat chronic conditions, such as Type 2 Diabetes.
Kidney Donor Contrast Exposure and Recipient Outcomes
Authors: Bajpai, MS2 Shivani , Mangus, MD MS FACS Richard S. 
Published: January 2019

The use of contrast media in hospital procedures has been increasing since its conception in 1923. Despite developments in utility and safety overtime, contrast media has been associated with inducing kidney injury in patients. Several studies have investigated contrast-induced nephropathy (CIN) in hospital patients and kidney recipients post-transplant. However, there are few studies that connect donor contrast exposure to recipient kidney outcomes. This was a single-center, retrospective study on single-organ deceased kidney donors and recipients (n=1585) to explore the impact of pre-transplant contrast procedures on post-transplant kidney outcomes. The results indicated that the first, peak, and last serum creatinine values were not useful markers of CIN in kidney donors. An analysis of those donors who had contrast exposure and those who did not, as well as the amount of contrast exposure in the donor prior to transplant did not conclude significant impact on the recipient kidney outcomes at time points ranging from 7 days to 1-year post transplant. This data provides the largest statistical evidence currently available on this topic; it establishes the foundation for various research developments moving forward.
Skin Sympathetic Nerve Activity and Rate Control of Atrial Fibrillation
Authors: Douglas II Anthony , Kusayama, MD, PhD Takashi , Chen, M.D Peng Sheng 
Published: January 2019

Background and Hypothesis
Lifetime risks for atrial fibrillation (AF) are 1 in 4 for people 40 years of age and older. Rate and rhythm control are both important strategies in managing patients with AF. However, not all patients respond to beta blocker therapy. We hypothesize that sympathetic tone is important in rate control of AF, but the importance varied among patients.
Experimental Design or Project Methods
neuECG is a new noninvasive method to record skin sympathetic nerve activity (SKNA) and electrocardiogram. The present research recruited and recorded 2 paroxysmal and 3 persistent AF patients for 24 hours using neuECG. The average voltage of SKNA (aSKNA) and ventricular rate during AF was analyzed in one-min windows.
Results
The preliminary data reveal strong correlations (r=.783, r=.640, respectively, p<0.0001 for both) between aSKNA (1.19 ± 0.21 µV) and ventricular rate (110 ± 8 bpm) in the paroxysmal AF. High correlations were consistently observed when data were analyzed on an hourly basis. In comparison, strong correlations were found between aSKNA (1.13 ± 0.2 µV) and ventricular rate (88 ± 8.6 bpm) in persistent AF (r=.496, r= .796, r=.636 respectively, p<0.001 for both cases). However, hourly correlations displayed much higher variability between aSKNA and ventricular rate than that observed for paroxysmal AF.
Conclusion and Potential Impact.
aSKNA positively correlates with ventricular rate during AF. This relationship is stronger and more consistent during paroxysmal than persistent AF. These findings may be important in determining the efficacy of beta blocker therapy in rate control of AF.