bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermediate-linkage steps used to obtain longitudinal data (containing heath service use, morbidity and mortality) for a large cohort of patients who are homeless that visited, and were discharged from hospital in England.
Authors: Evans Hannah , Blackburn Ruth , Cornes Michelle , Menezes Dee , Story Alistair , Hayward Andrew , Aldridge Robert 
Published: September 2018

IntroductionIn England, details on hospital admissions and mortality are recorded nationally, but housing status and patients’ hospital discharge arrangements are only recorded locally within discharge services. These data are required to evaluate specialist homeless hospital discharge (HHD) services in England, and can be obtained through linkage within and across sectors.
Objectives and ApproachWe aimed to improve linkage to enable the evaluation of HHD schemes. 16 sites with a scheme were recruited along with a specialist facility that deliver screening and treatment services to homeless hostels (Find\&Treat). Linkage fields including National Health Service number (NHS number), name, gender and birthdate for clinical contacts between November 2013 and November 2016 were collected and linked to national hospital data, Hospital Episodes Statistics (HES). To improve linkage with HES, intermediate-linkage to a gender-names dictionary and a national demographic database (NDD) was performed. Ethics, access permissions were obtained through HRA-REC (REC16/EE/0018) and NHS CAG (16/CAG/0021).
Results47,569 clinical contacts among people who were homeless were collected from Find&Treat and 12,931 from sites. The median age at mid-study period (15th May 2015) among contacts with sites compared to Find&Treat were similar at 44 (IQR 34-53, n=12,905) and 45 (IQR 35-54, n=47,569), respectively. Among Find&Treat, 82% (n=38,905) were contacts with Males and 18% (n=8,650) with Females. Gender was not collected at all HHD sites or for all admissions. 70% of contacts had missing gender and among these contacts, gender was assigned using the gender-names dictionary. After imputing gender, 52% of contacts all linkage fields and 47% had all but NHS number. These data were linked to the NDD, an approximate 60% linkage rate was achieved retrieving complete linkage fields for these contacts.
Conclusion/ImplicationsIntermediate linkage steps described here provides the largest dataset of it’s kind, enabling investigations into effectiveness of hospital discharge schemes in England. The study provides generally a proof of concept that large cohorts of hard-to-reach population groups can be obtained through data linkage.
Developing and implementing linked electronic medical record and administrative data in primary care practice for diabetes in Alberta
Authors: Drummond Neil , Taylor Matt , Garies Stephanie , Shaw Marta , Soos Boglarka , Cummings Michael , Forst Brian , Yaraee John , Cook Lisa 
Published: September 2018

IntroductionUse of administrative health data and primary care electronic medical record data are both ubiquitous in Alberta, but linkage between them at patient level and implementation of the linked data into primary care practice are rare. This demonstration project sought to achieve this for a sample of patients with diabetes.
Objectives and ApproachAcademic family physicians in the Department of Family Medicine at the University of Calgary who participate in the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) identified diabetes–related variables, either in their EMRs or in administrative data, that they wished to obtain in a linked dataset. Secure data linkage was obtained through Alberta Health Services (the provincial health authority) following transmission of patient mapping files direct from the clinics. The de-identified, linked, patient data was then transferred to CPCSSN-Alberta data managers for processing and displayed to users through an interactive Diabetes Dashboard.
Results2598 patients with diabetes were identified using a validated CPCSSN case definition from 47 family physicians in three clinics. CPCSSN EMR data included primary care encounters, date of diagnosis, deprivation index, BMI, blood pressure, comorbidity, diabetes medications prescribed, risk factors, etc. Administrative data included laboratory results (HbA1c, fasting blood glucose, cholesterol, triglycerides, creatinine), medication dispensed, emergency room visits, inpatient admissions and costs. Integrated, interactive provider reports were created and sent to participating physicians. The reports presented the information about diabetes patients at individual provider level, bench-marked at clinic, primary care network and provincial levels. Follow-up with providers led to further dashboard development . We propose to scale up implementation of the integrated diabetes database and dashboard to include all 23,000 CPCSSN-identified diabetes patients in Alberta.
Conclusion/ImplicationsIntegration of EMR and administrative data and its application to clinical care, panel management, and quality improvement in primary care, as well as to surveillance and research, was feasible and acceptable to the family physicians participating in this project.
Quality assessment of linked Canadian clinical administrative hospital and vital statistics death data
Authors: Rodrigues Nancy , Kelly Maureen , Henderson Tobi 
Published: September 2018

IntroductionThree Canadian clinical-administrative hospital databases were linked to the Canadian Vital Statistics Death Database (CVSD) to provide information about patients who died following discharge from hospital as well as supplementary information about patients that died in-hospital. Quality was assessed using a guided approach and through feedback from initial users.
Objectives and ApproachThe linked datasets were created to develop and validate health care indicators and performance measures and perform outcome analyses. It is therefore imperative to evaluate the data’s fitness for use. Quality was assessed by calculating coverage of deaths for all linked contributors, creating a profile of the linked dataset and analyzing issues that were identified by users. These analyses were guided by an existing Data Source Assessment Tool, which provides a set of criteria that allow for assessment across five dimensions of quality, thus allowing for appropriate determination of a given set of data’s fitness for use.
ResultsDeterministic linkage of the datasets resulted in linkage rates that ranged from 66.9% to 90.9% depending on the dataset or data year. Linkage rates also varied by Canadian jurisdictions and patient cohort. Variables had good data availability with rates of 95% or higher. Initial users identified a significant number of duplicate records that were flagged to and corrected by the data supplier. 1.4\% of acute hospital deaths had discrepancies in the death date captured in the two linked sources; the vast majority had a difference of only one day. A user group and issue tracking process were created to share information about the linked data and guarantee that issues are triaged to the appropriate party and allow for timely follow up with the data supplier.
Conclusion/ImplicationsDocumentation provided by the data supplier was vital to understanding the linkage methodology and its impact on linkage rates. A guided data assessment ensured that strengths and limitations were identified and shared to support appropriate use. Feedback to the data supplier is supporting ongoing improvements to the linkage methodology.
Empathic Cultural Mapping: Little data, big data, knowledge transfer and exchange
Authors: Goopy Suzanne , Turin Tanvir , Kassan Anusha , O'Brien Mary , McCormack Gavin , Chapman Jonathan , Charania Irina , Ferreira Carla , Silversides Halley 
Published: September 2018

IntroductionA healthy city is one that continually creates and improves psychosocial and social environments and expands community resources allowing people to develop to their maximum portential. The role of SEDoHs is incontestable, yet we continue to face many of the same SEDoH-related problems despite what we know.
Objectives and ApproachThis project presents the idea of "Empathic Cultural Mapping" (ECM). ECM is an interactive story map which brings together vignettes taken from individual stories curated with "big data" derived from places such as Statistics Canada, the City of Calgary, and library holdings at the University of Calgary. ECM seeks to challenge users to re-imagine long held constructions around sectoral, and disciplinary driven interpretations and categorizations of lifestyle, consumption, health, and the environment. ECM seeks to encourage knowledge users from multiple sectors to think beyond what is known and to consider what might be possible.
ResultsECM is a creative interactive undertaking. In developing ECM, a range of creative research processes have been used to record and tell the stories of a small group of newcomers (defined as those who migrate, seek refuge, or claim asylum in Canada) and position these within large data. A desire to improve the health and wellbeing of individuals and communties through opening processes of dialogoue between local government, non-government organizations, communitites, and individuals lies at the heart of this project. Knowledge and sense-making are key features of individual and community empowerment within the ECM and are viewed as powerful stimuli for change as well as powerful allies for health and a buffer against its threats.
Conclusion/ImplicationsECM creates, shares, and brings together individual stories and 'big data'. It identifies needs that impact health in the everyday. It seeks to improve awareness of the world around us. It encourages people to communicate their experiences. Finally, it achieves its goals by using creative processes.
Point of Care (POC) Influenza Immunization for Pregnant Women, Calgary Zone, Alberta Health Services
Authors: Manji Sofiya , McDonald Sheila , Metcalfe Amy , Nerenberg Kara , Zhang Jing , Castillo Eliana 
Published: September 2018

IntroductionVaccinating pregnant patients for neonatal protection needs to be integrated into prenatal care as new vaccines emerge. Uptake of influenza vaccine, universally recommended in pregnancy, is low. Immunization was offered and administered to pregnant women at point of care (POC) during two flu seasons at an urban tertiary care center.
Objectives and ApproachPrimary objective is to determine if POC impacts immunization rate during flu season among a cohort of pregnant women by location and gestational age. Secondary objectives are to examine the pattern of influenza-like illnesses (ILI) among vaccinated and unvaccinated women, and to describe pilot outcomes of POC. Four consecutive influenza seasons (2014/2015, 2015/2016, 2016/2017, 2017/2018) will be examined using seven databases: a) Clinibase, b) National Ambulatory Care Reporting System; C) Discharge Abstract Database; d) Physician Claims; e) Alberta Perinatal Health Program; f) Calgary Zone Public Health; and g) Pharmaceutical Information Network. Outcomes will be examined descriptively using frequencies and proportions.
ResultsBased on the preliminary analysis, approximately 10, 000 visits among 2,500 women occurred during each flu season at the four obstetric care locations: two outpatient clinics and two inpatient units. The proportion of pregnant women who received the flu vaccine ranged from 15-21% during the first three flu seasons. Majority of the women received the vaccine at the flu campaigns (range 48-67%), followed by pharmacy (20-32%). For the 2017-2018 season, year to date uptake rates in outpatient clinics are significantly higher. Final results on additional outcomes will be available by September 2018.
Conclusion/ImplicationsIn completing this study, we hope to better understand the patterns of immunization uptake in pregnancy by place of immunization and gestational age, i.e. identifying optimal “window of opportunity”. Results will inform the infrastructure needed to collect data on vaccines administered during pregnancy and linkage to maternal and infant outcomes.
Inventaire des ptéridophytes dans le Parc National d’El Kala (Algérie orientale)
Authors: Hamel Tarek , Boulemtafes Amir , Abdelmalek Bellili 
Published: September 2018

RésuméCette étude rapporte des données sur la diversité des Ptéridophytes du Parc National d’El Kala (Nord-Est algérien). Treize stations à caractéristiques écologiques différentes ont été prospectées; 27 espèces on été identifiés, dont 7 sont rares. L’inventaire de ces taxons constitue une étape importante pour le développement des stratégies de conservation des ressources génétiques et de la diversité des fougères et lycophytes sur l’ensemble de leur aire de distribution naturelle. Le statut des espèces et les principales menaces pour les habitats sont discutés.Mots clés: Fougères, Ptéridophytes, Algérie, menaces, conservation. AbstractInventory of pteridophytes in the El Kala National Park (Eastern Algeria)This study reports data on the diversity of the Pteridophyte of El Kala National Park (North east Algeria). Thirteen stations with different ecological characteristics were prospected; 27 species have been identified (7 of which are exceptionally rare).The inventory of these species constitutes an important stage for the development of the strategies of preservation of the genetic resources and the diversity of ferns and lycophytes on their whole area of natural distribution. The status of species and major threats to the habitats are discussed.Key words: Ferns, Pteridophytes, Algeria, threats, conservation.
Gastric dilatation and enterotoxemia in ten captive felids
Authors: Anderson Kadie M. , Garner Michael M. , Clyde Victoria L. , Volle Kurt A. , Ialeggio Donna M. , Reid Scott W. , Hobbs Jill K. , Wolf Karen N. 
Published: September 2018

Abstract
CASE DESCRIPTION 10 large felids at 8 facilities were determined or suspected to have developed gastric dilatation with or without enterotoxemia over a 20-year period. Four felids were found dead with no premonitory signs.
CLINICAL FINDINGS 4 felids (2 male snow leopards [Uncia uncia], 1 male Amur tiger [Panthera tigris altaica], and 1 male Sumatran tiger [Panthera tigris sumatrae]) were found dead or died before they could be evaluated. Six felids had hematemesis (1 male and 1 female African lion [Panthera leo] and 1 male jaguar [Panthera onca]) or abdominal distention and signs of lethargy with or without vomiting (1 male African lion, 1 male Malayan tiger [Panthera tigris jacksoni], and 1 female Sumatran tiger). Gastric dilatation was radiographically and surgically confirmed in the male Malayan and female Sumatran tigers and the jaguar.
TREATMENT AND OUTCOME In 3 felids with an antemortem diagnosis, the gastric dilatation resolved with decompressive laparotomy but then recurred in 1 felid, which subsequently died. Three others died at various points during hospitalization. Although Clostridium perfringens type A was recovered from 3 of the 5 felids for which microbial culture was performed, and 2 felids had a recent increase in the amount fed, no single factor was definitively identified that might have incited or contributed to the gastric dilatation.
CLINICAL RELEVANCE Gastric dilatation was a life-threatening condition in the large felids of this report, causing sudden death or clinical signs of hematemesis, abdominal distention, or vomiting. Even with rapid diagnosis and surgical decompression, the prognosis was poor. Research is needed into the factors that contribute to this emergent condition in large felids so that preventive measures might be taken.
Long-term survival of locally advanced stage III non-small cell lung cancer patients treated with chemoradiotherapy and perspectives for the treatment with immunotherapy
Authors: Vrankar Martina , Stanic Karmen 
Published: September 2018

Abstract

Background
Standard treatment for patients with inoperable locally advanced non-small cell lung cancer (NSCLC) is concurrent chemoradiotherapy (CCRT). Five-year overall survival rates range between 15 and 25%, while long term survival data are rarely reported.

Patients and methods
A total of 102 patients with stage III NSCLC treated between September 2005 and November 2010 with induction chemotherapy and CCRT were included in this long term survival analysis. All patients were tested for PD-L1 status and expression of PD-L1 was correlated with overall survival (OS), progression free survival (PFS) and toxicities.

Results
The median OS of all patients was 24.8 months (95% CI 18.7 to 31.0) with 10 year-survival rate of 11.2%. The median OS of patients with PD-L1 expression was 12.1 months (95% CI 0.1 to 26.2), while in patients with negative or unknown PD-L1 status was significantly longer, 25.2 months (95% CI 18.9 to 31.6), p = 0.005. The median PFS of all patients was 16.4 months (95% CI 13.0 to 19.9). PFS of patients with PD-L1 expression was 10.1 months (95% CI 0.1 to 20.4) and in patients with negative or unknown PD-L1 status was 17.9 months (95% CI 14.2 to 21.7), p = 0.003.

Conclusions
10-year overall survival of stage III NSCLC patients after CCRT is 11.2%. PFS and OS differ with regard to PD-L1 status and are significantly shorter for patients with PD-L1 expression. New treatment with check-point inhibitors combined with RT therefore seems reasonable strategy to improve these results.
Percutaneous parametrial dose escalation in women with advanced cervical cancer: feasibility and efficacy in relation to long-term quality of life
Authors: Akbaba Sati , Oelmann-Avendano Jan Tobias , Bostel Tilman , Rief Harald , Nicolay Nils Henrik , Debus Juergen , Lindel Katja , Foerster Robert 
Published: September 2018

Abstract

Background
We analyzed long-term quality of life (QoL) and prognostic factors for QoL as well as clinical outcome in patients with advanced cervical cancer (ACC) treated with primary radiochemotherapy (RChT) consisting of external beam radiotherapy (EBRT) with or without sequential or simultaneous integrated boost (SIB) to the parametria, intracavitary brachytherapy and concomitant chemotherapy (ChT).

Patients and methods
Eighty-three women were treated with primary RChT between 2008 and 2014. Survival of all patients was calculated and prognostic factors for survival were assessed in univariate and multivariate analysis. In 31 patients QoL was assessed in median 3 years (range 2–8 years) after treatment. QoL was compared to published normative data and the influence of age, tumour stage, treatment and observed acute toxicities was analyzed.

Results
Thirty-six patients (43.4%) died, 18 (21.7%) had a local recurrence and 24 (28.9%) had a distant progression. Parametrial boost (p = 0.027) and ChT (p = 0.041) were independent prognostic factors for overall survival in multivariate analysis. Specifically, a parametrial equivalent doses in 2-Gy fractions (EQD2) > 50 Gy was associated with an improved overall survival (OS) (p = 0.020), but an EQD2 > 53 Gy did not further improve OS (p = 0.194). Tumour size was the only independent prognostic factor for local control (p = 0.034). Lymph node status (p = 0.038) and distant metastases other than in paraaortic lymph nodes (p = 0.002) were independent prognostic factors for distant progressionfree survival. QoL was generally inferior to the reference population. Age only correlated with menopausal symptoms (p = 0.003). The degree of acute gastrointestinal (p = 0.038) and genitourinary (p = 0.041) toxicities correlated with the extent of chronic symptom experience. Sexual/vaginal functioning was reduced in patients with larger tumours (p = 0.012). Parametrial EQD2 > 53 Gy correlated with reduced sexual/vaginal functioning (p = 0.009) and increased sexual worry (p = 0.009). Whether parametrial dose escalation was achieved by sequential boost or SIB, did not affect survival or QoL.

Conclusions
Primary RChT is an effective treatment, but long-term QoL is reduced. The degree of acute side effects of RChT correlates with the extent of chronic symptoms. Patients benefit from parametrial SIB or sequential boost, but an EQD2 > 53 Gy does not further improve survival and negatively affects QoL.
Influence of short periods of increased water temperature on species composition and photosynthetic activity in the Baltic periphyton communities
Authors: Pniewski Filip , Sylwestrzak Zuzanna 
Published: September 2018

AbstractPeriphyton plays a vital ecological role in shallow, well-lit ecosystems which are vulnerable to rapidly changing environmental conditions, including raising temperature due to global warming. Nevertheless, little is known on the effect of increased temperatures on the taxonomic structure and functioning of periphytic communities. In this study, the influence of short-term temperature increase on the species composition and photosynthetic activity of the Baltic periphytic communities was investigated. The collected communities were exposed to increased temperature of 23 °C (ca. 4 °C above the summer average) for 72 h. After this time, species composition of the communities was studied under light microscope and their photosynthetic performance was evaluated using PAM fluorometry. Results showed that the biomass of cyanobacteria slightly increased. There were significant changes in the abundance of diatom species, among which Fragilaria fasciculata and Navicula ramosissima, were negatively affected by the elevated temperature and their cell number significantly decreased, whereas, Diatoma moniliformis and N. perminuta were stimulated by the increased temperature. Additionally, a shift towards higher abundance of smaller taxa was also observed. The higher quantum yield of photosystem II (PSII) (higher ΦPSII) accompanied by the lower value of non-photochemical quenching (NPQ) observed in communities kept at 23 °C showed more efficient photosynthesis. This was further confirmed by the changes in rapid light curves (higher photosynthetic capacity, rETRmax, and photoacclimation index, Ek). The obtained data constitute evidence that short periods of increased temperature significantly affect the structure and functioning of the Baltic periphyton.
PENGARUH GUNA LAHAN DAN POLA PERGERAKAN TERHADAP TINGKAT PELAYANAN JALAN DI SEKITAR BANDARA SOEKARNO HATTA
Authors: Damayanti Rizka 
Published: September 2018

Kemacetan lalu lintas merupakan salah satu masalah yang dihadapi pada akses pencapaian sekitar Bandara Soekarno Hatta. Fenomena hambatan samping pada akses non-Toll sekitar Bandara Soekarno Hatta perlu diidentifikasi guna memperoleh gambaran aktual pengaruhnya pada kemacetan, atau menurunnya kinerja jalan. Perpaduan dan kombinasi dari faktor-faktor guna lahan dan kinerja jalan akibat pola pergerakan yang terjadi merupakan potensi penyebab kemacetan pada ruas jalan di sekitar Bandara. Dengan latar belakang kondisi faktual tersebut maka perlu dilakukan studi yang mengkaji kinerja jalan, khususnya yang disebabkan oleh hambatan samping (pergerakan) sebagai pengaruh dari penggunaan lahan disekitarnya. Tujuan dari penelitian ini adalah menganalisis pengaruh pola penggunaan lahan terhadap pola pergerakan pada kawasan sekitar Bandara Soekarno Hatta