bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Spinopelvic Alignment on Pelvic Tilt after Total Hip Arthroplasty
Authors: Kanto Makoto , Maruo Keishi , Tachibana Toshiya , Fukunishi Shigeo , Nishio Shoji , Takeda Yu , Arizumi Fumihiro , Kusuyama Kazuki , Kishima Kazuya , Yoshiya Shinichi 
Published: May 2019

ObjectiveTo evaluate the impact of spinopelvic parameters and hip contracture on change in the pelvic tilt (PT) after Total hip arthroplasty (THA).MethodsOne hundred patients (15 male and 85 female) who underwent THA were included in this prospective study. Radiographic data were obtained preoperatively and 1 year after THA. Radiographic parameters included sagittal anterior pelvic plane (APP), sagittal vertical axis (SVA), sacral slope (SS), pelvic inclination (PI), and lumbar lordosis angle (LL). The APP was defined as the angle between the anterior pelvic plane and the vertical plane. A positive value indicates pelvic retroversion. Postoperative changes in PT were divided into three groups: the PA group (pelvic anteversion, ΔAPP < −5°), the PR group (pelvic retroversion, ΔAPP > 5°), and the PT group (minimal change, ΔAPP ≤ ± 5°). The Kruskal–Wallis test and the Steel–Dwass test were used to compare the preoperative and postoperative spinopelvic parameters among the three groups. The Spearman's rank correlation coefficient was used to evaluate the correlation between ΔAPP and spinopelvic parameters.ResultsMinimal change in pelvic tilt was observed in 59% of patients, while pelvic anteversion was observed in 16% of patients and pelvic retroversion was observed in 25% of patients. There were no significant changes in the spinopelvic parameters, including TK, LL, SVA, LL, SS, and APP after THA. The Femoral angle (FA) was significantly decreased after THA (P < 0.001). Preoperative APP was significantly more retroverted in the PA group than the PR group, and the PT group (6.8 ± 12.2, 0.2 ± 9.9, −8.3 ± 8.3, P < 0.001). Preoperative SS, PI‐LL, and PI were significantly smaller in the PA group than the PT group and the PR group. A significant negative correlation was identified between preoperative APP and ΔAPP (r = −0.418, P < 0.001).ConclusionApproximately 60% of the patients did not have any marked change in PT after THA. Preoperative APP was the only predictive factor associated with marked anterior or posterior change in PT.
Root vacuolar Na+ sequestration but not exclusion from uptake correlates with barley salt tolerance
Authors: Wu Honghong , Shabala Lana , Zhou Meixue , Su Nana , Wu Qi , Ul‐Haq Tanveer , Zhu Juan , Mancuso Stefano , Azzarello Elisa , Shabala Sergey 
Published: May 2019

SummarySoil salinity is a major constraint for the global agricultural production. For many decades, Na+ exclusion from uptake has been the key trait targeted in breeding programs; yet, no major breakthrough in creating salt‐tolerant germplasm was achieved. In this work, we have combined the microelectrode ion flux estimation (MIFE) technique for non‐invasive ion flux measurements with confocal fluorescence dye imaging technique to screen 45 accessions of barley to reveal the relative contribution of Na+ exclusion from the cytosol to the apoplast and its vacuolar sequestration in the root apex, for the overall salinity stress tolerance. We show that Na+/H+ antiporter‐mediated Na+ extrusion from the root plays a minor role in the overall salt tolerance in barley. At the same time, a strong and positive correlation was found between root vacuolar Na+ sequestration ability and the overall salt tolerance. The inability of salt‐sensitive genotypes to sequester Na+ in root vacuoles was in contrast to significantly higher expression levels of both HvNHX1 tonoplast Na+/H+ antiporters and HvVP1 H+‐pumps compared with tolerant genotypes. These data are interpreted as a failure of sensitive varieties to prevent Na+ back‐leak into the cytosol and existence of a futile Na+ cycle at the tonoplast. Taken together, our results demonstrated that root vacuolar Na+ sequestration but not exclusion from uptake played the main role in barley salinity tolerance, and suggested that the focus of the breeding programs should be shifted from targeting genes mediating Na+ exclusion from uptake by roots to more efficient root vacuolar Na+ sequestration.
Impact of Mixed Convective and Radiative Heat Transfer in
Spiral-Coiled Tubes
Authors: Kushwaha Naveen , Vikash  , Kumar Vimal 
Published: May 2019

Abstract
Spiral-coiled tube heat exchangers (SCTHE) have higher heat transfer as compared to the conventional heat transfer devices and are extensively used to extract heat from exhaust gases in the chemical processing industries and also from sunlight for domestic applications. However, no attention has been made to predict heat transfer characteristics considering combined convective and radiative heat transfer in spiral-coiled tubes. In the present study, numerical analysis has been performed to predict fluid flow and heat transfer characteristics by combined forced convection and thermal radiation in spiral-coiled tubes. The P-1 radiation and the renormalized group (RNG) k–ε turbulence models have been used to study the effect of thermal radiation and turbulent convection heat transfer in the spiral-coiled tube, respectively, over a wide range of Reynolds numbers (10,000–100,000) and curvature ratios (0.02–0.05). The emissivity and optical thickness have been varied from 0.0 to 1.0 and 0.0 to 8.0, respectively, to investigate the effect of thermal radiation on heat transfer characteristics in spiral-coiled tubes. For the considered Reynolds number range, it is found that the heat transfer is enhanced by approximately 10% when radiation is taken into account. It is found that the heat capacity increased with an increase in optical thickness and wall emissivity. Further, the effect of optical thickness on fully developed flow is observed weak and the average heat transfer coefficient is influenced by the wall emissivity over the entire flow.
Does voluntary medical male circumcision protect against sexually transmitted infections among men and women in real-world scale-up settings? Findings of a household survey in KwaZulu-Natal, South Africa
Authors: Davis Stephanie , Toledo Carlos , Lewis Lara , Maughan-Brown Brendan , Ayalew Kassahun , Kharsany Ayesha B M 
Published: May 2019

IntroductionMale circumcision (MC) confers partial protection to men against HIV and, in research settings, some sexually transmitted infections (STIs). It is also associated with protection from some STIs among female partners. However, real-world data on changes in STI transmission associated with large-scale public African medical male circumcision (MMC) conducted for HIV prevention are lacking and would improve estimates of the health impact of MMC.MethodsThe HIV Incidence Provincial Surveillance System is a community-based surveillance platform for HIV prevalence, incidence and intervention coverage trends in KwaZulu-Natal province, South Africa. HIPPS collected cross-sectional self-reported data on circumcision status (from men), partner circumcision status for past three partners (from women) and demographic characteristics and behavioural risk factors; and tested participants for HIV, herpes simplex virus type 2 (HSV-2), syphilis, hepatitis B,Neisseriagonorrhoeae,Chlamydiatrachomatis,TrichomonasvaginalisandMycoplasmagenitalium. Bivariable and multivariable analyses were performed on associations between own (men) or partner’s (women) circumcision status and each STI. Multivariable analyses adjusted for age, demographic characteristics and behavioural risk factors, and incorporated false discovery rate (FDR) correction.ResultsAmong men, MMC had a protective association with HSV-2 (OR 0.66, 95% CI 0.50 to 0.86), hepatitis B (OR 0.53, 95% CI 0.30 to 0.95), HIV (OR 0.50, 95% CI 0.38 to 0.65) andM.genitalium(OR 0.53, 95% CI 0.32 to 0.88). Among women, partner circumcision had a protective association with HSV-2 (OR 0.71, 95% CI 0.53 to 0.95) and HIV (OR 0.66, 95% CI 0.49 to 0.90). Associations with HIV and HSV-2 remained significant for men and all women after FDR correction.ConclusionThese real-world data, supporting protective associations between MMC conducted for HIV prevention and STIs in men and women, can help clarify the full impact of MMC and support a role in broader sexual health programming.
What do community health workers want? Findings of a discrete choice experiment among Accredited Social Health Activists (ASHAs) in India
Authors: Abdel-All Marwa , Angell Blake , Jan Stephen , Howell Martin , Howard Kirsten , Abimbola Seye , Joshi Rohina 
Published: May 2019

IntroductionA number of factors contribute to the performance and motivation of India’s Accredited Social Health Activists (ASHAs). This study aims to identify the key motivational factors (and their relative importance) that may help retain ASHAs in service.MethodsA discrete choice experiment (DCE) survey presented ASHAs with eight unlabelled choice sets, each describing two hypothetical jobs that varied based on five attributes, specifically salary, workload, travel allowance, supervision and other job benefits. Multinomial logit and latent class (LC) models were used to estimate stated preferences for the attributes.ResultWe invited 318 ASHAs from 53 primary health centres of Guntur, a district in south India. The DCE was completed by 299 ASHAs using Android tablets. ASHAs were found to exhibit a strong preference for jobs that incorporated training leading to promotion, a fixed salary and free family healthcare. ASHAs were willing to sacrifice 2530 Indian rupee (INR) from their monthly salary, for a job offering training leading to promotion opportunity and 879 INR for a free family health-check. However, there was significant heterogeneity in preferences across the respondents. The LC model identified three distinct groups (comprising 51%, 35% and 13% of our cohort, respectively). Group 1 and 2 preferences were dominated by the training and salary attributes with group 2 having higher preference for free family health-check while group 3 preferences were dominated by workload. Relative to group 3, ASHAs in groups 1 and 2 were more likely to have a higher level of education and less likely to be the main income earners for their families.ConclusionASHAs are motivated by both non-financial and financial factors and there is significant heterogeneity between workers. Policy decisions aimed at overcoming workforce attrition should target those areas that are most valued by ASHAs to maximise the value of investments into these workers.Trial registration numberCTRI/2018/03/012425.
Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS)
Authors: Mandrioli Jessica , Crippa Valeria , Cereda Cristina , Bonetto Valentina , Zucchi Elisabetta , Gessani Annalisa , Ceroni Mauro , Chio Adriano , D’Amico Roberto , Monsurrò Maria Rosaria , Riva Nilo , Sabatelli Mario , Silani Vincenzo , Simone Isabella Laura , Sorarù Gianni , Provenzani Alessandro , D’Agostino Vito Giuseppe , Carra Serena , Poletti Angelo 
Published: May 2019

IntroductionDisruptions of proteasome and autophagy systems are central events in amyotrophic lateral sclerosis (ALS) and support the urgent need to find therapeutic compounds targeting these processes. The heat shock protein B8 (HSPB8) recognises and promotes the autophagy-mediated removal of misfolded mutant SOD1 and TDP-43 fragments from ALS motor neurons (MNs), as well as aggregating species of dipeptides produced in C9ORF72-related diseases. In ALS-SOD1 mice and in human ALS autopsy specimens, HSPB8 is highly expressed in spinal cord MNs that survive at the end stage of disease. Moreover, the HSPB8–BAG3–HSP70 complex maintains granulostasis, which avoids conversion of dynamic stress granules (SGs) into aggregation-prone assemblies. We will perform a randomised clinical trial (RCT) with colchicine, which enhances the expression of HSPB8 and of several autophagy players, blocking TDP-43 accumulation and exerting crucial activities for MNs function.Methods and analysisColchicine in amyotrophic lateral sclerosis (Co-ALS) is a double-blind, placebo-controlled, multicentre, phase II RCT. ALS patients will be enrolled in three groups (placebo, colchicine 0.01 mg/day and colchicine 0.005 mg/day) of 18 subjects treated with riluzole; treatment will last 30 weeks, and follow-up will last 24 weeks. The primary aim is to assess whether colchicine decreases disease progression as measured by ALS Functional Rating Scale - Revised (ALSFRS-R) at baseline and at treatment end. Secondary aims include assessment of (1) safety and tolerability of Colchicine in patiets with ALS; (2) changes in cellular activity (autophagy, protein aggregation, and SG and exosome secretion) and in biomarkers of disease progression (neurofilaments); (3) survival and respiratory function and (4) quality of life. Preclinical studies with a full assessment of autophagy and neuroinflammation biomarkers in fibroblasts, peripheral blood mononuclear cells and lymphoblasts will be conducted in parallel with clinic assessment to optimise time and resources.Ethics and disseminationThe study protocol was approved by the Ethics Committee of Area Vasta Emilia Nord and by Agenzia Italiana del Farmaco (EUDRACT N.2017-004459-21) based on the Declaration of Helsinki. This research protocol was written without patient involvement. Patients’ association will be involved in disseminating the study design and results. Results will be presented during scientific symposia or published in scientific journals.Trial registration numberEUDRACT 2017-004459-21;NCT03693781; Pre-results.
Body mass index and treatment response to subcutaneous abatacept in patients with psoriatic arthritis: apost hocanalysis of a phase III trial
Authors: McInnes Iain B , Ferraccioli Gianfranco , D'Agostino Maria-Antonietta , Le Bars Manuela , Banerjee Subhashis , Ahmad Harris A , Elbez Yedid , Mease Philip J 
Published: May 2019

ObjectiveThispost hocanalysis of the phase III Active PSoriaTic Arthritis RAndomizEd TriAl (ASTRAEA) evaluated the effect of baseline body mass index (BMI) on subsequent response to subcutaneous (SC) abatacept in patients with psoriatic arthritis (PsA).MethodsIn ASTRAEA, patients with active PsA were randomised (1:1) to receive blinded weekly SC abatacept 125 mg or placebo for 24 weeks. Treatment response at week 24 was assessed by the proportions of patients achieving American College of Rheumatology 20% improvement response, Disease Activity Score in 28 joints (DAS28 (C reactive protein (CRP))) ≤3.6 and <2.6, Health Assessment Questionnaire-Disability Index reduction from baseline ≥0.35 and radiographic non-progression (defined as change from baseline ≤0 in PsA-modified total Sharp/van der Heijde score). Responses were stratified by baseline BMI (underweight/normal, <25 kg/m2; overweight, 25–30 kg/m2; obese, >30 kg/m2) and compared in univariate and multivariate models.ResultsOf 212/213 and 210/211 patients with baseline BMI data in the abatacept and placebo groups, respectively, 15% and 19% were underweight/normal, 36% and 27% were overweight, and 49% and 54% were obese. After adjusting for baseline characteristics, there were no significant differences for any outcome measure at week 24 with abatacept in the overweight or obese versus underweight/normal subgroup. In the placebo group, patients in the obese versus underweight/normal subgroup were significantly less likely to achieve DAS28 (CRP) <2.6 at week 24 (OR 0.26; 95% CI 0.08 to 0.87; p=0.03).ConclusionBMI does not impact clinical or radiographic response to SC abatacept in patients with PsA.Trial registration numberNCT01860976.
Dynamics of quantum correlations for three-qubit states in a noisy environment
Authors: Liu Tian-Wen , He Zhi-Yuan , Hou Xi-Wen 
Published: May 2019

Girolami and coworkers have proposed measures of quantum correlations and weaving [Girolami et al., Phys. Rev. Lett. 119, 140505 (2017)]. This work derives the analytic time-evolution of such measures and weaving for two kinds of initial states in three qubits under an amplitude-damping and a dephasing noisy environment. It is shown that the 2-partite correlation is forever frozen, which is dependent on an initial state and the property of noise.
O-Tū-Kapua (What Clouds See): A Mixed Reality Exploration of Atmospheric Science
Authors: Coulson Guy , Jowsey Susan , Williams Marcus , Olivares Gustavo 
Published: May 2019

Abstract
The authors’ project O-Tū-Kapua (what clouds see) explored concepts related to air quality by creating a mixed reality, art/science, educationally focused exhibition for children, mixing participatory art, scientific concepts and technology. The young are directly affected by the social and environmental impacts of the changing world climate, making their voices particularly important in determining ongoing dialogue about Earth's atmosphere. Through a nexus of the handmade, education, augmented technology, installation and aural soundscapes, O-Tū-Kapua engaged over 1,000 children. The project also combined real-time air quality and weather data, superimposing it as a virtual data layer on top of hand-drawn images of native flora and fauna. The magnitude of the data determined the visual and aural form of the virtual experience, creating environmentally responsive representations that enabled participants to readily see and interpret how the atmosphere was affecting the native forest in their neighborhood.
Perinatal anxiety and depression: Awareness and attitudes in Australia
Authors: Smith Terri , Gemmill Alan W , Milgrom Jeannette 
Published: May 2019

Background: Better community mental health literacy is associated with positive help-seeking behaviours and reduced stigma. There are relatively few published surveys of perinatal mental health literacy. Aims: To provide a profile of current awareness, knowledge and attitudes in relation to the mental health of women and men in the perinatal period. Method: A cross-sectional online survey ( n = 1,201) of adults (⩾ 18 years) in each state and territory of Australia was conducted in early 2016. Survey questions were based on a previous 2009 survey, with the addition of several novel items designed to assess knowledge around both perinatal anxiety and men’s perinatal mental health. Results: Depression (including postnatal depression) was the most frequently cited general health problem for women in the first postnatal year (52% of spontaneous first responses). Over 70% of adults believed that postnatal depression requires specialised treatment and checks for depressive symptoms should occur routinely in pregnancy and the first postnatal year. Women identified postnatal depression at a higher rate than men. Most commonly, postnatal depression was perceived as having a biological rather than psychosocial etiology (34.5%). Men and women differed in their knowledge about the symptoms of postnatal depression with more women correctly identifying core depressive symptoms. The specific term ‘perinatal depression’ was not well recognised. Although not well recognised as a general health issue, when prompted, 39% of respondents were aware of anxiety as a specific perinatal mental health issue. Most adult Australians (60%) were unaware that perinatal depression and anxiety could be experienced by men. Conclusion: Awareness of postnatal depression appeared high. However, areas including anxiety, antenatal mental health, and men’s mental health were less well-understood. There remains considerable scope, and a need for, continued awareness-raising around anxiety, mental health in pregnancy and men’s mental health.
Evaluation of Healing Rates and Safety With a Bioinductive Collagen Patch for Large and Massive Rotator Cuff Tears: 2-Year Safety and Clinical Outcomes
Authors: Thon Stephen G. , O’Malley Larry , O’Brien Michael J. , Savoie Felix H. 
Published: May 2019

Background:Failure of repair of large and massive rotator cuff tears is a challenging problem within orthopaedics. Poor tendon tissue and vascularity are known causes for failure of rotator cuff repairs.Purpose:To assess the safety, outcomes, and healing rates when large and massive rotator cuff repairs are augmented with a bioinductive collagen scaffold patch in a proof-of-principle design.Study Design:Case series; Level of evidence, 4.Methods:Twenty-three patients undergoing repair of full-thickness large (2-tendon) or massive (3-tendon) rotator cuff tears augmented with a bioinductive collagen patch were enrolled in a prospective single-arm proof-of-principle study. No partial repairs were performed, and a complete rotator cuff repair was successfully achieved in each case. Sixteen patients underwent revision rotator cuff repairs versus 7 primary repairs. Safety was determined by any implant-related adverse event. A single magnetic resonance imaging (MRI) scan was utilized to confirm tendon healing and thickness at a minimum of 6 months postoperatively. Postoperative ultrasound (US) was used in office by the treating surgeon to assess tendon thickness at 3-, 6-, 12-, and 24-month intervals. American Shoulder and Elbow Surgeons (ASES) scores were collected at final follow-up.Results:Overall, a 96% (22 of 23) healing rate was confirmed on US and MRI. However, incidence of treatment clinical failure was 9% (2 of 23), as 1 patient’s tendon healed but eventually underwent additional surgery. There were no adverse events attributed to the implant reported. Final US rotator cuff thickness was 7.28 ± 0.85 mm (mean ± SD), and final MRI rotator cuff thickness was 5.13 ± 1.06 mm. The mean ASES score at final follow-up was 82.87 ± 16.68 (range, 53.33-100).Conclusion:No complications attributed to the implant were reported, and new tendon formation was apparent on US and MRI, with relatively high healing rates at 2-year follow-up. Arthroscopic application of this bioinductive collagen scaffold when combined with rotator cuff repair is a safe and effective treatment for healing of large and massive rotator cuff repairs.