bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of dietary anthocyanidins intake with all-cause mortality and cardiovascular diseases mortality in USA adults: a prospective cohort study
Authors: Yan Yifei , Li Jianchang 
Published: November 2024

AbstractAnthocyanins, as a type of polyphenolic compound, have been discovered to offer multiple health benefits to humans, including anti-aging and anti-inflammatory properties. This prospective cohort study aims to examine the relationship of dietary intake of anthocyanin with all-cause mortality and cardiovascular diseases mortality in the US. The aim of this research was to explore the possible correlation between anthocyanin consumption and the mortality rate from all causes as well as from cardiovascular disease. Based on the Public Access NHANES-linked National Death Index files up to December 31, 2019, we identified mortality status and heart disease-specific causes of death. A multivariate Cox regression analysis was employed to evaluate the effects of anthocyanin intake on mortality outcomes, generating hazard ratios and 95% confidence intervals, adjusting for various demographic characteristics, lifestyle factors, and comorbid conditions. Additionally, we utilized Kaplan-Meier survival curves, subgroup analyses. In different scenarios, dietary anthocyanin intake was assessed using restricted cubic spline models. A total of 11,959 participants completed the final cohort, averaging 47.12 years of age (SD ± 0.35). Following adjustments for multiple variables, an inverse relationship was identified between anthocyanin intake in the highest quartile and all causes mortality, yielding a hazard ratio (HR) of 0.68 (95% CI: 0.52–0.89). Similarly, elevated anthocyanin consumption was linked to a reduction in heart disease mortality, with HR of 0.61 (95% CI: 0.38–0.97). Additionally, dose–response curve revealed a consistent decrease in both all-cause and cardiovascular mortality with increasing anthocyanin intake. Further subgroup analyses revealed that elevated intake of anthocyanins was linked to decreased all-cause mortality in White individuals and males. Moreover, high anthocyanin intake was significantly correlated with reduced all-cause mortality irrespective of hypertension or hyperlipidemia status. Our research indicates that an appropriate dietary intake of anthocyanins is associated with a reduction in overall mortality rates. Furthermore, the findings reveal a substantial association between anthocyanin intake and decreased mortality from cardiovascular diseases, suggesting that anthocyanins may effectively lower the risk of cardiovascular-related deaths.
Age related grid-wise spatial analysis of choroidal parameters in well characterised healthy population
Authors: Kumar Meenakshi , Trinh Matt , Zhang Angela , Wei Xin , Agrawal Rupesh , Nivison-Smith Lisa 
Published: November 2024

AbstractChoroidal vascularity index (CVI) is an image-based metric applied to assess the choroid in disease but poorly explored in natural aging. In this retrospective cohort study, we assessed a single eye of 309 healthy individuals from 20 to 70 + years, and quantified spatial topography of total choroidal area (TCA), luminal area (LA), stromal area (SA) and CVI (LA: TCA) in cluster and standard retinal templates using a semi-automated approach. CVI was found to be greatest in the central vs. periphery (CVIcentral 67.08% [66.85–67.73] vs. CVIperiphery65.68% [65.32–66.01], p < 0.01). In this study, CVI also showed no significant change with age or physiological factors. Area parameters demonstrated greater magnitude in the central versus periphery but with a superior bias: TCAsuperior 0.227mm2 [0.223–0.233] vs. TCAinferior 0.207mm2 [0.201–0.213], p < 0.01.They also showed a linear decline with age (TCA:-0.00112 to -0.00169 mm2/year; LA: -0.00074 to -0.00112 mm2/year; SA: -0.00039 to -0.00056 mm2/year, p < 0.0001), with a higher rate of decline inferiorly (p < 0.001). This study demonstrates that CVI exhibits specific spatial differences across macula, independent of age. It further establishes a comprehensive, normative database of CVI and other choroidal angioarchitecture metrics which is a valuable resource for distinguishing pathological changes from normal age-related variations in future assessments of choroid-involving diseases.
Enhanced federated anomaly detection through autoencoders using summary statistics-based thresholding
Authors: Laridi Sofiane , Palmer Gregory , Tam Kam-Ming Mark 
Published: November 2024

AbstractIn Federated Learning, Anomaly Detection poses significant challenges due to the decentralized nature of data, especially under Non-IID distributions. This study proposes a federated threshold calculation method that aggregates summary statistics from normal and anomalous data across clients to create a global threshold for Anomaly Detection with federated Autoencoders, enhancing detection accuracy and robustness while ensuring privacy. Extensive experiments on datasets, including Credit Card Fraud Detection, Shuttle, and Covertype, show that our approach consistently outperforms existing federated and local threshold calculation methods. These findings highlight the potential of summary statistics in improving federated Anomaly Detection under Non-IID conditions.
Uncovering patients’ preferences for brand among essential classes of coronary heart disease medications using a discrete choice experiment
Authors: Elmongui Ehab , Abu-Sheasha Ghada , Zaki Adel , Yassine Omaima Gaber , Abd Elhameed Asmaa 
Published: November 2024

AbstractPatient preferences for medications strongly correlate with adherence; one area of interest is the choice between branded and generic drugs. Despite extensive research about brand-versus-generic drug preferences, few studies have explored severe-illness patients like those with coronary heart disease (CHD). We could not locate studies measuring preference weights of branded drugs in different classes within guideline-recommended regimens using discrete choice experiments (DCE). We aimed to explore the preference for branded medications used for secondary prevention of CHD events among patients receiving treatment at one of the largest Egyptian health insurance clinics. Patients with CHD were interviewed to choose between various therapy regimens containing brand-name and generic versions of aspirin, beta-blockers, statins, and renin–angiotensin–aldosterone system blockers (RAAS blockers). The study employed a DCE technique and followed the recommendations of the International Society of Pharmacoeconomics and Outcomes Research (ISPOR). Seventy-two percent (149) of the 208 patients questioned were dissatisfied with at least one of their generic medications. The majority of unsatisfied patients displayed brand preferences across the four medicine classes, primarily due to the notion that generics may be less effective. Patients preferred the RAAS blocker brand the most (adjusted odds ratio [AOR]: 3.14; 95% confidence interval [CI] 2.83 to 3.48), followed by beta-blockers (AOR: 2.06; 95% CI 1.88 to 2.27) and statins (AOR: 1.5; 95% CI 1.50 to 1.61). The relative importance of each class from the patient’s perspective showed the highest importance with RAAS blockers (22.2%) and beta-blockers (14.1%), while statins and aspirin had minor importance (7.8% and 6.6%, respectively). In the present study, branded drugs for secondary CHD prevention were preferred over generic alternatives. This finding has two implications for clinical practice. Firstly, physicians and pharmacists need to assure patients about the quality of generics to insure patient satisfaction and adherence to medication. Secondly, health insurance providers need to confirm the effectiveness of generics through observational studies. Despite the well-proven protective effects of aspirin and statins, they had minor importance from the patient’s perspective, highlighting the need to enhance patient knowledge. DCE was demonstrated to be a useful tool for eliciting the genuine preferences of patients treated within the setting of health insurance.
A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds
Authors: Müller Monja , Ludwig Lars , Englert Hanna , Riedl Katharina A. , Müller May Cathleen , Hemkemeyer Sandra A. , Beerens Manu , Mailer Reiner K. , Renné Thomas , Lang Sabine , Baumann-Zumstein Philine , Frye Maike 
Published: November 2024

AbstractCoronary artery disease (CAD) is characterized by narrowing and subsequent blockade of coronary arteries, and imposes a significant health and economic burden. Stent and scaffold devices are introduced in advanced CAD to improve vascular stability and restore blood flow. Although in vitro flow systems like the Chandler loop have been developed to enhance the understanding of interactions between device materials, their coatings, and vascular cells, imaging-based in vitro analysis of device performance is limited. In this study, we established a novel stent flow chamber system designed to assess the thrombogenicity of bioresorbable magnesium scaffold (RMS) and stent materials in vitro. Additionally, we compared the thrombogenicity – an important clinical parameter in stent performance – of the Magmaris-316 L stainless steel stent with its predecessors, Magmaris RMS and a prototype of the third-generation RMS (DREAMS 3G). Analysis of platelet adhesion and coverage of the different devices under flow conditions demonstrated that the Magmaris RMS exhibits reduced thrombogenicity compared to the Magmaris-316 L stainless steel stent. Moreover, thrombogenicity of the DREAMS 3G prototype, composed of BIOmag material, is further decreased compared to its predecessors. The observed reduction in thrombogenicity of the DREAMS 3G prototype in vitro suggests additional improvements in clinical safety and efficacy, highlighting its promise for treating CAD. Future research on this prototype may thus open avenues for analyzing other blood components and patient-derived endothelial cells. In line with the 3R principles, this approach may also help reduce the need for animal testing.
Tumor growth and vascular redistribution contributes to the dosimetric preferential effect of microbeam radiotherapy: a Monte Carlo study
Authors: Ortiz Ramon , Ramos-Méndez José 
Published: November 2024

AbstractThe radiobiological mechanisms behind the favorable response of tissues to microbeam radiation therapy (MRT) are not fully described yet. Among other factors, the differential action to tumor and normal tissue vasculature is considered to contribute to MRT efficacy. This computational study evaluates the relevance of tumor growth stage and associated vascular redistribution to this effect. A multiscale approach was employed with two simulation softwares: TOPAS and CompuCell3D. Segmentation images of the angioarchitecture of a non-bearing tumor mouse brain were used. The tumor vasculature at different tumor growth stages was obtained by simulating the tumor proliferation and spatial vascular redistribution. The radiation-induced damage to vascular cells and consequent change in oxygen perfusion were simulated for normal and tumor tissues. The multiscale model showed that oxygen perfusion to tissues and vessels decreased as a function of the tumor proliferation stage, and with the decrease in uniformity of the vasculature spatial distribution in the tumor tissue. This led to an increase in the fraction of hypoxic (up to 60%) and necrotic (10%) tumor cells at advanced tumor stages, whereas normal tissues remained normoxic. These results showed that tumor stage and spatial vascular distribution contribute to the preferential effect of MRT in tumors.
The role of cydB gene in the biofilm formation by Campylobacter jejuni
Authors: Korkus Jakub , Sałata Patrycja , Thompson Stuart A. , Paluch Emil , Bania Jacek , Wałecka-Zacharska Ewa 
Published: November 2024

AbstractCampylobacter jejuni is a major cause of food- and water-borne bacterial infections in humans. A key factor helping bacteria to survive adverse environmental conditions is biofilm formation ability. Nonetheless, the molecular basis underlying biofilm formation by C. jejuni remains poorly understood. Around thirty genes involved in the regulation and dynamics of C. jejuni biofilm formation have been described so far. We applied random transposon mutagenesis to identify new biofilm-associated genes in C. jejuni strain 81–176. Of 1350 mutants, twenty-four had a decreased ability to produce biofilm compared to the wild-type strain. Some mutants contained insertions in genes previously reported to affect the biofilm formation process. The majority of identified genes encoded hypothetical proteins. In the library of EZ-Tn5 insertion mutants, we found the cydB gene associated with respiration that was not previously linked with biofilm formation in Campylobacter. To study the involvement of the cydB gene in biofilm formation, we constructed a non-marked deletion cydB mutant together with a complemented mutant. We found that the cydB deletion-mutant formed a weaker biofilm of loosely organized structure and lower volume than the parent strain. In the present study, we demonstrated the role of the cydB gene in biofilm formation by C. jejuni.
Speaking valve with integrated biomimetic overpressure release and acoustic warning signal
Authors: Knorr N. , Auth P. , Kruppert S. , Stahl C. A. , Lücking K. M. , Tauber F. , Speck T. 
Published: November 2024

Abstract
Speaking valves enable tracheostomy patients to speak naturally. However, improper use may cause dangerous overpressure, leading to severe complications or even patient’s death. We address this life-threatening issue by creating a biomimetic speaking valve, which incorporates an integrated overpressure valve that automatically opens when reaching critical pressure levels. To enhance safety, we integrated a whistle module to provide an audible alert for medical staff. Fundamental research on the Utricularia vulgaris trapdoor inspired our abstracted valve form. Through a comprehensive analysis using generalized linear mixed-effect models, we examined various membrane parameter effects on the function of the biomimetic overpressure valve. This enabled us to adjust the valve’s opening pressure to cater to patient’s unique requirements, thus potentially saving lives by applying a solution from nature.
Contagious yawning and scratching in captive lemurs
Authors: Lemes William Padilha , Amici Federica 
Published: November 2024

AbstractBehavioral contagion is thought to play a significant role in social synchronization and coordination across animal taxa. While there is extensive evidence of behavioral contagion in Haplorrhines (i.e. monkeys and apes), limited research exists in Strepsirrhines (i.e. lemurs). Here, we aimed to investigate the presence of contagious yawning and scratching in two captive groups of black-and-white ruffed lemurs (Varecia variegata) (N = 4) and red ruffed lemurs (Varecia rubra) (N = 4), and further test whether behavioral contagion is modulated by the model’s social integration in the group. We conducted all occurrence sampling to examine whether individuals observing a yawning or scratching event (i.e. trigger event) were more likely to yawn or scratch in the following 2 min, as compared to individuals who did not observe it. We ran generalized linear mixed models and found that the likelihood of yawning and scratching was higher for subjects observing the trigger event than for subjects who did not observe the event, although the model’s social integration had no modulating effect on the probability of showing behavioral contagion. Our findings represent the first evidence of behavioral contagion in this genus and contribute to shed light on the distribution and the possible adaptive function of this phenomenon in primates.
Thermal equation of state of rhodium characterized by XRD in a resistively heated diamond anvil cell
Authors: Rodrigo-Ramon Jose Luis , Anzellini Simone , Cazorla Claudio , Botella Pablo , Garcia-Beamud Aser , Sanchez-Martin Josu , Garbarino Gaston , Rosa Angelika D. , Gallego-Parra Samuel , Errandonea Daniel 
Published: November 2024

AbstractThe high-pressure and high-temperature structural, mechanical, and dinamical stability of rhodium has been investigated via synchrotron X-ray diffraction using a resistively heated diamond anvil cell and density functional theory. The isothermal compression data have been fitted with a Rydberg-Vinet equation of state (EoS) with best-fitting parameters $$V_0$$

V
0

=55.046(16) Å$$^3$$

3

, $$K_0$$

K
0

= 251(3) GPa, and $$K'_0$$

K
0
′

= 5.7(2). The thermal equation of state has been determined based upon the data collected following four different isotherms and has been fitted to a Holland and Powell thermal equation-of-state model with $$\alpha _0=$$

α
0

=

3.36(7)x10$$^{-5}$$

-
5

K$$^{-1}$$

-
1

. The measured equation of state and structural parameters have been compared to the results of ab initio simulations. The agreement between theory and experiments is generally quite good. The present results solve controversies between previous studies which reported values of the bulk modulus from 240 to 300 GPa.
Numerical modeling the process of deep slab dehydration and magmatism
Authors: Wu Hao , Lei Jiacheng , Jia Zeyu , Sheng Jian , Zhu Yinan , Wang Jian 
Published: November 2024

AbstractThis study uses a 2D high-resolution thermo-mechanical coupled model to investigate the dynamic processes of deep plate hydration, dehydration, and subsequent magmatic activity in ocean-continent subduction zones. We reveal the pathways and temporal evolution of water transport to the deep mantle during the subduction process. Plate dehydration plays a critical role in triggering partial melting of the deep mantle and related magmatic activity. Our study shows significant differences in the volumes of melt produced at different depths, with dehydration reactions in deeper regions being weaker compared to shallower ones. It takes a longer time to reach the suitable P-T conditions for hydrous melting in the deep mantle. The results highlight the geophysical significance of water transport in deep subduction zones and its role in magmatic processes, particularly in the formation of magma chambers beneath continental plates.
Circadian rhythm and daytime variation do not affect intraoperative bacterial sternal contamination and postoperative wound infections following cardiac surgery
Authors: Immohr Moritz Benjamin , Sugimura Yukiharu , Hartmann Michelle , Moza Ajay , Akhyari Payam , Aljalloud Ali 
Published: November 2024

AbstractStudies have documented various effects of circadian rhythm and daytime variations on the cardiovascular and immune system as well as wound healing. From June to December 2016, n = 367 cardiac surgery patients were enrolled. Microbiological swabs from the mediastinum and subcutaneous wound were taken before sternal closure. Patients were assigned to groups based on operation start: morning (n = 219) or afternoon (n = 135). Bacterial contamination and wound infections were studied in relation to circadian rhythm and daytime variation. We did not observe any difference in mortality (morning: 3.7%, afternoon: 3.0%, p > 0.99) and major adverse events (morning: 8.2%, afternoon: 5.9%, p = 0.53). In 27.7% of the morning group, at least one positive intraoperative swab was observed, similar to the afternoon group (25.6%, p = 0.71). The incidence of positive presternal swabs was 15.6% in the morning compared to 9.1% in the afternoon (p = 0.18). About 90% of the germs detected were part of the natural skin flora (e.g., Cutibacterium acnes and Staphylococcus epidermidis). The incidence of sternal wound infections was 7.3% (morning) and 3.0% (afternoon) (p = 0.18). We did not find differences in the incidence of intraoperative bacterial sternal contamination, nor postoperative infections, between patients who underwent cardiac surgery in the morning or afternoon.
Thoughts From the Front Lines: Canadian Perspectives in Adopting and Implementing Recommended Clinical Labels in Preschool Speech-Language Pathology
Authors: Csercsics Alison Lynn , Denusik Lauren , Cunningham Barbara Jane 
Published: November 2024

Purpose:
Previous literature has proposed barriers to speech-language pathologists (SLPs) using standard clinical labels; however, the perspectives of SLPs have been studied to a lesser extent. This quality improvement project reports on SLPs' perceived barriers and facilitators to using currently recommended clinical labels for preschool communication disorders and identifies next steps to support implementation in one preschool communicative health system.

Method:
This project aimed to establish the consistent use of clinical labels in one large Canadian preschool speech and language program. After completing a web-based training and a 3-month trial period, 387 SLPs completed an exit survey to share their perceived barriers and facilitators to label use. Qualitative survey data were analyzed using a hybrid codebook inductive/deductive thematic analysis approach.

Results:
Six themes were identified, which aligned with the diffusion of innovations theory. SLPs identified several facilitators and barriers to using the recommended clinical labels within each theme. Major facilitators included improved communication, better caregiver understanding of children's communication, positive feedback from caregivers, SLPs' increased confidence in sharing labels, and improved access to services for children. Major barriers related to additional time required to share labels, SLPs' perceptions of caregivers' values, SLPs' views surrounding the recommended labels, lack of comfort using some labels, and limited opportunity to practice label use or observe successful label use by others.

Conclusions:
Contextual barriers continue to impact SLPs' use of the recommended clinical labels. Ongoing collaboration with SLPs and caregivers will be critical for supporting implementation. Further research examining SLPs' perspectives across other clinical settings and geographic areas is needed.

Supplemental Material:

https://doi.org/10.23641/asha.27296970