bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of retinal morphology of canine sudden acquired retinal degeneration syndrome using optical coherence tomography and fluorescein angiography
Authors: Osinchuk Stephanie C. , Leis Marina L. , Salpeter Elyse M. , Sandmeyer Lynne S. , Grahn Bruce H. 
Published: August 2018

AbstractPurposeTo describe the optical coherence tomography (OCT) and fluorescein angiography changes in dogs with sudden acquired retinal degeneration syndrome (SARDS).MethodsRetinal OCT was performed on 10 SARDS dogs and eight control dogs. Tomograms were collected in four quadrants around the optic nerve. Measurements were collected from the photoreceptor layer, the outer nuclear layer, the outer retina, the inner retina and the whole retina thickness in all quadrants. Sodium fluorescein was injected intravenously and serial fundic photographs were collected for a 5 minute period post‐injection.ResultsIn all quadrants, the outer nuclear layer (dorsal temporalP = 0.0000, dorsal nasalP = 0.0001, ventral temporalP = 0.0002, ventral nasalP = 0.000) and outer retina (dorsal temporalP = 0.0001, dorsal nasalP = 0.0002, ventral temporalP = 0.0054, ventral nasalP = 0.0084) measurements were significantly decreased in SARDS dogs. The whole retina thickness was significantly decreased in the dorsal temporal (P = 0.0082) and ventral temporal (P = 0.0428) retina. There were no significant differences in the photoreceptor layer thickness or inner retinal thickness between SARDS and control dogs. All SARDS dogs had a loss of definition of all of the photoreceptor bands on OCT. Two SARDS dogs had multifocal small retinal detachments and one of these dogs exhibited fluorescein leaking at the detachment sites.ConclusionsThe significant reduction in the outer nuclear layer and the loss of band signals in the photoreceptor layers in dogs with SARDS identified on OCT support the previous histopathology findings. Small detachments may occasionally be detected on OCT and they may leak fluorescein.
High field magnetic resonance imaging is comparable with gross anatomy for description of the normal appearance of soft tissues in the equine stifle
Authors: Daglish Jodie , Frisbie David D. , Selberg Kurt T. , Barrett Myra F. 
Published: August 2018

AbstractHigh field magnetic resonance imaging (MRI) is increasingly used for horses with suspected stifle disease, however there is limited available information on normal imaging anatomy and potential incidental findings. The aim of this prospective, anatomic study was to develop an optimized high field MRI protocol for evaluation of the equine stifle and provide detailed descriptions of the normal MRI appearance of the stifle soft tissues, using ultrasound and gross pathological examination as comparison tests. Nine cadaver limbs were acquired from clinically normal horses. Stifles were evaluated ultrasonographically and then by an extensive 1.5 T MRI protocol. Subsequently, all stifles were evaluated for gross pathologic change. Findings were compared between gross evaluation and MRI imaging and described. No soft tissue structure abnormalities were identified on any evaluation. Specific descriptive findings of the meniscotibial, meniscofemoral, collateral, patellar and cruciate ligaments, and the menisci were reported. The high field MRI protocol described in this study provided high spatial and contrast resolution of the soft tissue structures, and this in turn allowed visualization of detailed structural characteristics, such as striations and variations in signal intensity. Findings supported the use of high field MRI as a modality for the evaluation of the soft tissues of the equine stifle. As clinical availability of this modality increases in the future, authors anticipate that new stifle diseases will be detected that have not previously been identified with other imaging modalities.
Themes of Reflective Thinking as a Predictor of Physical Education and Sport Pre-Service Teachers’ the Entrepreneurial Characteristics
Authors: Adatepe Sadık , Kul Murat 
Published: August 2018

Today, entrepreneurship has gained great importance, especially with the transition from industrial society to information society. Therefore, in order to ensure economic and social development of societies, entrepreneurship must comprehensively be supported, encouraged and entrepreneurship education has to be provided. Many similar qualities and skills among individuals having reflective thinking abilities and entrepreneurial individuals arise when reflective thinking, one of the higher-level thinking skills, is defined as the cognitive inquiry that will lead the individual to produce new knowledge and develop alternative ways. The purpose of this research is to identify whether physical education and sports teachers' reflective thinking themes predict entrepreneurial characteristics. Research is designed in accordance with the relational screening model. Semerci (2007), “Reflective Thinking Tendency Scale” and Yilmaz and Sunbul (2009), “Entrepreneurship Scale for University Students” were used as data collection tool. Multilevel regression analysis was benefitted in the analyze of the data. As a result of this research, it is determined that effective and interrogated teaching sub-dimension was the most independent variable contributing to the entrepreneurial characteristics of physical education and sports pre-service teachers and this was followed by continuous and intentional thinking, responsibility of teaching and science and looking professional sub-dimensions. It has also been determined that sub-dimensions such as open-mindedness, foresighted and sincere and researcher do not make a meaningful contribution to the prediction of entrepreneurial characteristics. Based on these results, it can be said that a pre-service teacher with high entrepreneurial characteristics will have higher reflective thinking tendencies. Besides, it is also possible to analyze how thinking skills such as critical thinking, creative thinking, problem solving and supra-cognitive thinking predict entrepreneurial characteristics.
Effect of Microstructures on Superhydrophobic and Slippery Lubricant-Infused Porous Surfaces During Condensation Phase-Change
Authors: Orejon Daniel , Maeda Yota , Lv Fengyong , Zhang Peng , Takata Yasuyuki 
Published: August 2018

Superhydrophobic surfaces (SHSs) and slippery lubricant-infused porous surfaces (SLIPSs) are receiving increasing attention for their excellent anti-icing, anti-fogging, self-cleaning and condensation heat transfer properties. The ability of such surfaces to passively shed and repel water is mainly due to the low-adhesion between the liquid and the solid surface, i.e., low contact angle hysteresis, when compared to hydrophilic or to hydrophobic surfaces. In this work we investigated the effect of surface structure on the condensation performance on SHSs and SLIPSs. Three different SHSs with structures varying from the micro- to the nano-scale were fabricated following easy and scalable etching and oxidation growth procedures. The condensation performance on such surfaces was evaluated by optical microscopy in a temperature and humidity controlled environmental chamber. On SHSs important differences on the size and on the number of the coalescing droplets required for the jump to ensue were found when varying the surface structure underneath the condensing droplets. A surface energy analysis is proposed to account for the suppression of the droplet-jumping performance in the presence of microstructures. On other hand, by impregnating the same SHSs with a low surface tension oil, i.e., SLIPSs, the adhesion between the condensate and the SLIPSs can be further reduced. On SLIPSs slight differences on the droplet density over time and shedding performance upon the inclusion of microstructures were observed. Droplets were found to shed faster and with smaller diameters on SLIPSs in the presence of microstructures when compared to solely nanostructured SLIPSs.
We conclude that on SHSs the droplet-jumping performance of micrometer droplets is deteriorated in the presence of microstructures with the consequent decrease in the heat transfer performance, whereas on SLIPSs the droplet self-removal is actually improved in the presence of microstructures.
Serotype-specific immunity explains the incidence of diseases caused by human enteroviruses
Authors: Pons-Salort Margarita , Grassly Nicholas C. 
Published: August 2018

Hidden truths of enteroviruses
Enteroviruses are important drivers of global health, but few countries undertake enterovirus surveillance. Pons-Salort and Grassly used Japanese surveillance data to model the interplay between the ratio of susceptible and immune individuals, accounting for declining birth and death rates, incomplete surveillance, and seasonality of infection (see the Perspective by Nikolay and Cauchemez). Enteroviruses have highly predictable yet highly nonlinear dynamics. The model also reveals signatures of increased pathogenicity and of antigenic change and transmissibility.

Science
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800
; see also p.
755
Relation of serum uric acid to asymptomatic proximal extracranial artery stenosis in a middle-aged Chinese population: a community-based cross-sectional study
Authors: Yang Xiaolei , Lv Haichen , Hidru Tesfaldet Habtemariam , Wu Jing , Liu Henghui , Wang Youxin , Liu Kejia , Xia Yunlong , Zhou Yong , Jiang Yinong 
Published: August 2018

ObjectiveSerum uric acid (SUA) has been associated with cardiovascular diseases, including atherosclerosis and carotid artery stenosis. However, data on the relationship between SUA level and proximal extracranial artery stenosis (PEAS) are limited. Therefore, this study investigates the association between SUA levels and the risk of PEAS in asymptomatic Chinese population.SettingThis community-based cross-sectional study was conducted in Jidong Community Hospital, Tangshan, Hebei, China between July 2013 and August 2014.ParticipantsThe study examined 3325 asymptomatic participants (40–60 years) to evaluate the risk of PEAS.ResultsFor the participants stratified into quartiles based on gender-specific SUA levels, the prevalence of PEAS increased from Q1 to Q4 from 12.3% to 29.8% in the vertebral artery (VA), and from 2.8% to 5.8% in the common carotid artery. The proportion of PEAS relative to the detected number of arterial stenosis was lower in Q1 than in Q2–Q4. The multivariable ORs and 95% CI of PEAS in the second through fourth compared with the lowest quartiles for arterial stenosis were 1.278 (0.980 to 1.665), 1.117 (0.851 to 1.468) and 1.375 (1.033 to 1.830) (ptrend=0.0399); and for VA stenosis, 1.285 (0.966 to 1.709), 1.085 (0.808 to 1.457) and 1.439 (1.061 to 1.952) (ptrend=0.0235).ConclusionElevated SUA concentration is significantly associated with PEAS in an asymptomatic middle-aged Chinese population, and vertebral arteries appeared to be the most vulnerable vessels.
Impact of the communication and patient hand-off tool SBAR on patient safety: a systematic review
Authors: Müller Martin , Jürgens Jonas , Redaèlli Marcus , Klingberg Karsten , Hautz Wolf E , Stock Stephanie 
Published: August 2018

ObjectivesCommunication breakdown is one of the main causes of adverse events in clinical routine, particularly in handover situations. The communication tool SBAR (situation, background, assessment and recommendation) was developed to increase handover quality and is widely assumed to increase patient safety. The objective of this review is to summarise the impact of the implementation of SBAR on patient safety.DesignA systematic review of articles published on SBAR was performed in PUBMED, EMBASE, CINAHL, Cochrane Library and PsycINFO in January 2017. All original research articles on SBAR fulfilling the following eligibility criteria were included: (1) SBAR was implemented into clinical routine, (2) the investigation of SBAR was the primary objective and (3) at least one patient outcome was reported.SettingA wide range of settings within primary and secondary care and nursing homes.ParticipantsA variety of heath professionals including nurses and physicians.Primary and secondary outcome measuresAspects of patient safety (patient outcomes) defined as the occurrence or incidence of adverse events.ResultsEight studies with a before–after design and three controlled clinical trials performed in different clinical settings met the inclusion criteria. The objectives of the studies were to improve team communication, patient hand-offs and communication in telephone calls from nurses to physicians. The studies were heterogeneous with regard to study characteristics, especially patient outcomes. In total, 26 different patient outcomes were measured, of which eight were reported to be significantly improved. Eleven were described as improved but no further statistical tests were reported, and six outcomes did not change significantly. Only one study reported a descriptive reduction in patient outcomes.ConclusionsThis review found moderate evidence for improved patient safety through SBAR implementation, especially when used to structure communication over the phone. However, there is a lack of high-quality research on this widely used communication tool.Trial registrationnone
Engaging patients and family members in the evaluation of a mental health patient portal: protocol for a mixed-methods study
Authors: Strudwick Gillian , Kuziemsky Craig , Booth Richard G , Collins Sarah , Chyjek Anna , Sakal Moshe , Harris Alexandra , Strauss John 
Published: August 2018

IntroductionTwenty per cent of Canadians will experience a mental illness in any year. Mental health patient portals have been developed to support these individuals in taking more control over their own mental health and care. This may be done through electronic access to their health records and other supportive functions like completion of online self-assessments. To date, there has been limited research into the value that these portals may provide within mental health contexts. This study will identify what value mental health patient portals may offer to patients and their family members.Methods and analysisThis study will use a mixed-methods design. Patients will complete a survey consisting of validated instruments at the time of enrolment in the portal, and at 3 and 6 months of portal use. Patient and family member focus groups will be conducted. Portal usage data will be collected to identify if there are differences in outcomes based on usage. The study will be done at Canada’s largest mental health and addiction teaching hospital, and will be conducted using a patient and family-oriented research approach, engaging these important representatives in all stages of the research process. The primary data analysis for the survey portion of the study will be done using linear mixed-effect models, assessing the differences between patients with different portal usage levels. A thematic analysis will be conducted of the focus group transcripts.Ethics and disseminationApproval from the study site’s Research Ethics Board has been obtained. The dissemination of findings of this study will be done through presentations at conferences, as well as a formal peer-reviewed journal article. Additionally, the research team will work with a group of patients and family members to identify opportunities to complete knowledge translation and dissemination activities in non-traditional venues.
Discovering bugs, or ensuring success?
Authors: Bugayenko Yegor 
Published: August 2018

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Contribution of peripheral airway function to changes in FEV1/FVC and RV/TLC with aging
Authors: Htun Christopher , Pope Alun , Lahzami Samir , Luo Darren , Schoeffel Robin E. , Farrow Catherine E. , Phillips Craig L. , Robinson Paul D. , King Gregory G. 
Published: August 2018

Multiple breath nitrogen washout (MBNW) indices provide insight into ventilation heterogeneity globally [lung clearance index (LCI)] and within acinar (Sacin) and conducting (Scond) airways. Normal aging leads to an accelerated deterioration of Sacinin older adults, but little is known about the contribution of peripheral airway function to changes in pulmonary function indices reflecting expiratory airflow [forced expiratory volume in one second (FEV1)/forced vital capacity (FVC)] and gas trapping [residual volume (RV)/total lung capacity (TLC)] with aging. We aimed to examine associations between MBNW and FEV1/FVC as well as RV/TLC in healthy adults, and to determine if these relationships differ in older (≥50 yr) versus younger subjects (<50 yr). Seventy-nine healthy adult volunteers aged 23–89 yr with no cardiac or respiratory disease and a smoking history of <5 pack-years underwent spirometry, plethysmography, and MBNW. After adjustment for sex, height, and body mass index, the following relationships were present across the entire cohort: Sacinwas inversely related to FEV1/FVC (R2 = 0.22, P < 0.001); Sacinand Scondwere positively related to RV/TLC (R2 = 0.53, P < 0.001); on separate analyses, the relationship between Sacinand FEV1/FVC was strongest in the older group (R2 = 0.20, P = 0.003) but markedly weaker in the younger group (R2 = 0.09, P = 0.04); and Sacinand Scondwere related to RV/TLC in older (R2 = 0.20, P = 0.003) but not younger subgroups. No relationships were observed between LCI and FEV1/FVC or RV/TLC. Changes in FEV1/FVC and RV/TLC are at least in part due to changes in peripheral airway function with aging. Further studies of the relationships between MBNW and standard pulmonary function indices may prove useful for their combined application and interpretation in obstructive airways disease.NEW & NOTEWORTHY This study explores associations between multiple breath nitrogen washout (MBNW) and standard pulmonary function indices reflecting expiratory airflow [forced expiratory volume in one second (FEV1)/forced vital capacity (FVC)] and gas trapping [residual volume (RV)/total lung capacity (TLC)] in healthy adults across a wide range of ages. We have demonstrated statistically significant relationships between MBNW and FEV1/FVC as well as RV/TLC. These findings provide novel evidence of the contribution of peripheral airway function to changes in standard pulmonary function indices with aging.
Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice
Authors: Hashimoto Ayumi , Gao Chan , Mastio Jerome , Kossenkov Andrew , Abrams Scott I. , Purandare Ashok V. , Desilva Heshani , Wee Susan , Hunt John , Jure-Kunkel Maria , Gabrilovich Dmitry I. 
Published: August 2018

Abstract
The role of myeloid cells as regulators of tumor progression that significantly impact the efficacy of cancer immunotherapies makes them an attractive target for inhibition. Here we explore the effect of a novel, potent, and selective inhibitor of serine/threonine protein kinase casein kinase 2 (CK2) on modulating myeloid cells in the tumor microenvironment. Although inhibition of CK2 caused only a modest effect on dendritic cells in tumor-bearing mice, it substantially reduced the amount of polymorphonuclear myeloid-derived suppressor cells and tumor-associated macrophages. This effect was not caused by the induction of apoptosis, but rather by a block of differentiation. Our results implicated downregulation of CCAAT-enhancer binding protein-α in this effect. Although CK2 inhibition did not directly affect tumor cells, it dramatically enhanced the antitumor activity of immune checkpoint receptor blockade using anti-CTLA-4 antibody. These results suggest a potential role of CK2 inhibitors in combination therapies against cancer.
Significance: These findings demonstrate the modulatory effects of casein kinase 2 inhibitors on myeloid cell differentiation in the tumor microenvironment, which subsequently synergize with the antitumor effects of checkpoint inhibitor CTLA4. Cancer Res; 78(19); 5644–55. ©2018 AACR.
Antipredatory behaviour of a mountain lizard towards the chemical cues of its predatory snakes
Authors: Ortega Zaida , Mencía Abraham , Pérez-Mellado Valentín 
Published: August 2018

Abstract
The ability to early detect a potential predator is essential for survival. The potential of Iberolacerta cyreni lizards to discriminate between chemical cues of their two predatory snakes Coronella austriaca (a non-venomous active-hunter saurophagous specialist) and Vipera latastei (a venomous sit-and-wait generalist) was evaluated herein. A third snake species, Natrix maura, which does not prey on lizards, was used as a pungent control. Thus, the behaviour of I. cyreni was studied regarding four treatments: (1) C. austriaca scent, (2) V. latastei scent, (3) N. maura scent and (4) odourless control. Lizards showed antipredator behaviour (such as slow-motion and tail waving) to C. austriaca and V. latastei chemicals. The antipredatory response was similar for both predators. This ability to react with an intensive behavioural pattern to the chemical cues of their predatory snakes may prevent lizards from being detected, and, if detected, dissuade the predator from beginning a pursuit.
Top management teams’ shared leadership and ambidexterity: the role of management control systems
Authors: Umans Timurs , Smith Elin , Andersson William , Planken William 
Published: August 2018

The study explores how top management teams’ shared leadership is related to organizational ambidexterity in public-sector organizations, theoretically and empirically considering how this relationship is contingent on the management control system. Using a sample of 85 Swedish municipal housing corporations, we find that shared leadership has a positive relationship with organizational ambidexterity in public-sector organizations. Moreover, increasing use of new public management control systems, based on combined reward and performance controls, positively moderates this relationship. The study also finds that traditional public management control systems, based on combined planning and administrative controls, do not moderate the relationship between top management teams’ shared leadership and organizational ambidexterity. Accordingly, this article contributes to the public and strategic management literature, as well as to managerial practice. Points for practitioners The article suggests that sharing leadership within top management teams can result in a balanced resource allocation in municipal corporations. To be more effective in achieving this balance, public sector managers might consider emphasizing new public management-inspired management control systems and de-emphasizing those of a more traditional type.