bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving treatment outcomes for patients with HER2‑positive breast cancer using neoadjuvant double HER2 blockade
Authors: Semiglazov V. F. , Bekkeldieva N. B. , Komyakhov A. V. , Komyakhov A. V. , Paltuev R. M. , Tseluyko A. I. , Gigolaeva L. P. , Tabagua T. T. , Zhiltsova E. K. , Apollonova V. S. , Dashyan G. A. , Kudaybergenova A. G. , Ivanov V. G. , Bozhok A. A. , Ulrikh D. G. , Gorina A. O. , Semiglazova T. Yu. 
Published: November 2024

Background. Dual anti-HER2-targeted therapy in breast cancer (BC) significantly increased the rate of pathological complete response (pCR) compared to single blockade when added to chemotherapy. However, limited data exist on the long-term impact on survival of the additional increase in pCR.Aim. To improve recommendations regarding HER2-targeted agents and chemotherapy in the neoadjuvant treatment of BC.Materials and methods. N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia took participation in some clinical trials of neoadjuvant treatment of HER2-positive breast cancer, including NeoSphere and NeoALTTO. In multicenter, open-label, phase 2 randomised NeoSphere trial, patients with locally advanced, inflammatory, or early-stage HER2-positive BC were randomly assigned to receive four neoadjuvant cycles of trastuzumab (8 mg/kg loading dose, followed by 6 mg/kg every 3 weeks) plus docetaxel (75 mg/m2 from every 3 weeks, increasing to 100 mg/m2 from cycle 2 if tolerated) (group A), pertuzumab (420 mg every 3 weeks) and trastuzumab plus docetaxel (group B), pertuzumab and trastuzumab (group C), or pertuzumab and docetaxel (group D). After surgery, patients received three cycles of FEC. Рatients in group C received four cycles of docetaxel prior to FEC, and trastuzumab 6 mg/kg every 3 weeks to complete 1 years treatment. In NeoALTTO trial from 455 patients 154 patients received lapatinib, 149 – trastuzumab, 152 – combination of lapatinib and trastuzumab.Results. Between 2007, and 2009, 417 patients were randomly assigned to group A (107 patients), group B (n = 107), group C (n = 107), or group D (n = 96). At clinical cutoff, 87 patients had disease progression or died. 5-year progressionfree survival rates were 81 % (95 % confidence interval (CI) 71–87) for group A, 86 % (95 % CI 72–91) for group B, 73 % for group C, and 73 % for group D (95 % CI 0.34–1.40). Disease-free survival rates were consistent with progressionfree survival rates and were 81 % (95 % CI 72–88) for group A, 84 % (95 % CI 72–91) for group B, 80 % (95 % CI 70–86) for group C, and 75 % (95 % CI 64–83) for group D. In NeoALTTO trial patients who achieved pCR had longer progressionfree survival (85 % (95 % CI 76–91)) compared with patients who did not achieve pCR (76 % (95 % CI 71–81)).Conclusion. High levels of progression-free survival and disease-free survival at 5–10-years follow-up show large and overlapping CI, but support the primary endpoint (pCR) and suggest that neoadjuvant pertuzumab is beneficial when combined with trastuzumab and docetaxel. Additionally, they suggest that pCR could be an early indicator of long-term outcome in early-stage HER2-positive BC.
Evidence for Low Effective Stress Within the Crust of the Subducted Gorda Plate from the 2022 December Mw 6.4 Ferndale Earthquake Sequence
Authors: Guo Hao , Atterholt James W. , McGuire Jeffrey J. , Thurber Clifford 
Published: November 2024

Abstract
Stress levels on and adjacent to megathrust faults at seismogenic depths remain a key but difficult-to-constrain parameter for assessing seismic hazard in subduction zones. Although strong ground motions have been observed to be generated from distinct, high-stress regions on the down-dip end of the megathrust rupture areas in many great earthquakes, we lack direct constraints on the stress level in the lower seismogenic portion of the Cascadia megathrust. On 20 December 2022, an Mw 6.4 strike-slip earthquake occurred near Ferndale, California, in southern Cascadia and likely ruptured the Gorda slab crust in the lower seismogenic portion, providing an opportunity to assess the stress level in this region. Here, we relocate the Ferndale mainshock and the first two weeks of aftershocks using a high-resolution 3D velocity model and estimate rupture dimensions, directivity, and stress drop for several Mw 4–5 aftershocks and recent earthquakes. The aftershocks define a strike-slip fault in the slab crust striking east-northeast, consistent with the mainshock focal mechanism. The orientation of this fault is about 45° off the ideally oriented fault plane given the stress state in the slab. The aftershock zone is extensive and broad in the forward direction of the mainshock rupture but still constrained within the volume of high VP/VS in the slab crust. Our stress-drop estimates are generally lower for Mw 4–5 earthquakes located in the slab crust compared to those a few kilometers deeper in the slab mantle. Combined, our results support a relatively low effective stress level in the vicinity of the megathrust in the lower portion of the seismogenic zone in southern Cascadia, likely due to elevated fluid pressures. Consequently, the ground motion in the onshore region above this low-stress seismogenic portion in southern Cascadia may not be as intense as that observed during great earthquakes in other subduction zones.
Planowanie miast
Authors: Abbott Carl , Sokołowicz Mariusz E. 
Published: November 2024

Krótkie wprowadzenie do planowania miast stanowi przegląd rozwoju tej dziedziny wiedzy i akcentuje jej ważną rolę w coraz bardziej zurbanizowanym świecie. Odwołuje się przede wszystkim do dorobku architektury i urbanistyki, choć zawiera także nawiązania do ekonomii i socjologii miast oraz do zagadnień ekologicznych. Fascynująca opowieść o miastach toczy się wokół siedmiu obszarów planowania, takich jak: projektowanie układu ulic, równowaga między koncentracją zabudowy a jej rozproszeniem, rewitalizacja najstarszych dzielnic miejskich, konflikty na tle różnic społecznych i etnicznych, zarządzanie w dużych regionach miejskich, traktowanie miast jako systemów naturalnych oraz odporność na zagrożenia lub szoki naturalne i społeczno-ekonomiczne. Dane te wskazują, jak planowanie ewoluowało na przestrzeni lat, gdy kolejne pokolenia planistów rozwijały nowe podejścia w odpo­wiedzi na przemiany zachodzące w gospodarce i społeczeństwie.

City Planning: A Very Short Introduction was originally published in English in 2020. This translation is published by arrangement with Oxford University Press. Wydawnictwo Uniwersytetu Łódzkiego is responsible for this translation from the original work and Oxford University Press shall have no liability for any errors, omissions or inaccuracies or ambiguities in such translation or for any losses caused by reliance thereon.
Seismostratigraphic Analysis of the Vaca Muerta Formation in the Veta Escondida-Rincon de Aranda Area, Neuquén Basin
Authors: Miotti Gonzalo Preboste 
Published: November 2024

Abstract
This paper presents the results obtained from the seismic stratigraphic analysis conducted on the Vaca Muerta Formation, of Tithonian - Berriasian age, in the Rincon de Aranda (RDA) and Veta Escondida (VE) fields, located in the northeastern sector of the transition between the central and marginal areas of the Neuquén Basin. The Vaca Muerta Formation is the main source rock in this basin, playing a significant role in the production of unconventional gas and oil. This study identifies and characterizes the interval corresponding to the Vaca Muerta Formation through seismic and well data analysis. The study involved creating sections, interpreting seismic horizons, and generating isochronous, isopach, seismic attribute, structural, and isopach maps, which provided a better understanding of the stratigraphic characteristics of the Vaca Muerta Formation within the specified reservoir. Various surfaces and internal intervals within the Vaca Muerta Formation were identified through well profile analysis and comparison with data from adjacent areas. Deep structural trends oriented NW-SE impact the Tordillo Formation and, to a lesser extent, the Vaca Muerta Formation. These trends reduce structural deformation in the upper sections, creating echelon faults oriented NNW-SSE and negative flower structures, as observed in Rincon de Aranda. An increase in thickness was observed towards the SW, related to the depocenter of the basin and the Entre Lomas structural high to the east of the area. Less deep O-E oriented lineaments are interpreted as related to Andean orogeny and have their greatest impact on the levels corresponding to the Quintuco Formation and upper sections such as the Loma Montosa Formation. The studied area displays a mixed platform depositional system with a total thickness of 570 meters from the Loma Montosa Formation to the base of the Vaca Muerta Formation, with 170 meters of this thickness specifically corresponding to the Vaca Muerta Formation. In the northern sector of Veta Escondida, area and intrusive igneous bodies were detected, affecting the seismic interpretation.
Integration of Carbon Emissions Quantification and Reduction in Project Design and Selection
Authors: Irazuzta Natalia , Veolia WTS 
Published: November 2024

Abstract
The objective seems to be very clear, carbon footprint needs to be reduced in all the activities that humans do, but specially in those that will have greater impact, such as processes associated with the Oil and Gas industry. The difficult part seems to be how to do it, or at least, how to start.
The first logical step in the road to reduce something is to know how much of it there is, or, in this case, it is being produced. If the intention is to include the Green House Gases (GHG) emissions calculation and, therefore, reduction objectives, in all project decisions, a simpler way to measure it should be developed. The aim of this paper is to show a method that was designed and applied, to simplify the identification of GHG emissions throughout several processes and activities, and the following quantification using a company tool (Veolia´s GHG Calculation Tool), to find feasible and effective reduction actions.
Some real cases will be shown, revealing how it was possible to easily include carbon footprint when selecting variants within certain projects. Although the cases are originally related to chemical treatments, mainly for production and fracture in Oil and Gas fields, the application can be extrapolated to other divisions. This work provides several examples showing how the understanding of emissions and the fractioning of operations into simple unit tasks is essential to make an adequate comparison. The aim is to demonstrate that the incorporation of GHG emissions calculation in the analysis of projects is relatively simple, and how it is possible to consider it as a central aspect when designing or selecting projects, resulting, many times, the best GHG emission option, consistent with the most favorable alternative from an economic or operational point of view.
Additionally, the quantification of the reduction obtained thru certain choices regarding chemical treatments will be shown.
Increasing Energy Efficiency in PCP Systems
Authors: Boonstra A. , Romano L. , Robles L. , Heras L. , Rodríguez E. 
Published: November 2024

Abstract
In mature exploitation fields with a considerable number of active wells, efficient and sustainable operation management is required. In this context, the management and optimization of resources become crucial to maintaining profitability and long-term sustainability. This article presents the results of a business case in which PCP drivehead with electric asynchronous motor are replaced by permanent magnet drivehead. This case is supported by a field trial that validated, for the asset, a current reduction between 16 and 27% with the technology replacement. Additionally, all the advantages of this technology are presented.
Enhanced Automation for Detecting and Managing Well Downtime Events
Authors: Cordoba Axel Leonel 
Published: November 2024

Abstract
Optimizing the management of production losses in mature fields is essential to maximizing operational efficiency, particularly in large- scale reservoirs such as Cerro Dragón. One of the most critical challenges is the accurate and timely identification of well downtime events and the determination of their root causes, which are key aspects for the effective allocation of resources and strategic decision- making.
This paper describes the development of an advanced automation tool designed for detecting and managing downtime events in production wells. The tool not only enables the automatic identification of downtime events but also provides intelligent suggestions regarding the probable causes of these events, logging this information while seamlessly integrating with existing management and control systems.
The methodological approach comprised several key stages: the design and development of the detection algorithm, its validation through rigorous testing, and its final implementation in a real operational environment. The results demonstrate a significant reduction in the time required for manual data entry, along with substantial improvements in the accuracy and consistency of event detection. These advancements not only optimize operational efficiency but also provide a robust framework for real-time, data-driven decision- making.
Rigview-Ar: Augmented Technology for Safe and Efficient Maintenance and Operations
Authors: Sanjurjo S. , Carnero M. A. Sanchez 
Published: November 2024

Abstract
This paper discusses an optimization project at the Cerro Dragón field, operated by Pan American Energy in Argentina, aimed at enhancing efficiency and reducing costs in a mature field. The project outlines a series of innovations to be implemented in the future, aiming to modernize processes without relying on expensive external technologies.
Among the key innovations planned are the development of a real-time monitoring system to enable remote supervision of drilling operations. This tool is designed to improve decision-making and data management by providing access to critical information from any location. Additionally, a visual and auditory alarm system will be developed for a more effective response to emergencies, along with a mobile application for instant task stoppage recording and management.
In maintenance, the integration of augmented reality and 3D models is planned to enhance personnel training and equipment tracking. This technology will facilitate a deeper understanding of equipment and components without the need for physical field visits. Moreover, the use of QR codes and mobile applications will allow for faster and more accurate updates to maintenance information.
The anticipated conclusions of the project highlight the importance of these innovations in optimizing operational efficiency, safety, and maintenance in the drilling sector. The proposed technologies aim not only to improve current processes but also to set a precedent for digital transformation in the industry. Future steps will include integrating geological data and developing new applications for alarm and spare parts management, solidifying the progress towards greater modernization and efficiency in operations.
Novel Unsupervised Algorithm for 3D Reservoir Modeling Based on Percolation in Complex Networks
Authors: Llanes J. , Delgado M. , Juri J. E. 
Published: November 2024

Abstract
Three-dimensional reservoir models are an essential decision-making tool for geoscientists to understand the by-passed oil in multilayer fluvial systems in San Jorge Basin. The dedicated reservoir teams spend significant amounts of time to build three-dimensional models to decrease risk in the implementation of chemical EOR projects, particularly in the assessment of reservoir connectivity. Traditional 3D static reservoir modelling requires important effort to construct the structural models, interwell correlation and facies modeling. The objective of this work is to present the implementation of a computational algorithm that generates three-dimensional reservoir models. We successfully tested its capability to adequately represent the structural model, interwell correlation, and facies propagation from the well log data without any previous interpretation.
This work is based on the application of label propagation/ label spreading on the graph network using the three-dimensional percolation theory with considerations of the phase transition of the system. This methodology is powerful, since it does not consider the distance between the input data, but rather its distance in a graph network.
The results of the novel unsupervised algorithm show a good match between the existing 3D geological models made by experienced geologists and the model made by the computational algorithm implemented. Finally, we performed several sensitivity analyses to better understand the tuning parameters.
This novel approach for 3D reservoir modelling is characterized by the percolation in complex networks. One of the keys is that the generated 3D reservoir models have an unbiased geological interpretation and have the capability to quickly downscale/upscale the 3D grid with tuning parameters.
Legal Issues of Ensuring Technological Sovereignty
Authors: Zaloilo M. V. 
Published: November 2024

Objective: to identify the legal issues of ensuring technological sovereignty and to determine scientifically grounded vectors of their solution.Methods: the study is based on formal-legal, historical-legal, comparative legal methods, as well as the methodology of soft systematicity, legal forecasting, and legal modeling. Results: the article presents a theoretical and legal approach to understanding sovereignty and differentiating its types. Under modern conditions, a significant role is given to the independence and autonomy of the state in the technological sphere. The correlation of digital and technological sovereignty is considered; the latter notion is outlined taking into account the gaining popularity of the Western concept of digital (technological) solidarity. The regulatory foundation of the state strategic autonomy is legal regulation, in which the concept of technology-centrism has been firmly established in recent years. The technological paradigm of modern legal regulations was identified. It consists in strategizing the scientific and technological innovations in strategic planning documents, as well as in sovereignization and cyclization of the legal sphere, digital transformation of the culture of lawmaking and law enforcement, technologization of the legal language, expansion of the scope of legislative regulation and the volume of subordinate legislation. The analysis of the correlation between the legislative and subordinate law levels of technological positioning of the Russian Federation in strategic areas has allowed to emphasize the important systemic interrelation of the involved traditional and innovative law-making tools as they ensure technological development. The author also identifies the risks of expanding legal experimentation in the digital area of public relations, which should exclude the possibility of circumventing the established critical limitations.Scientific novelty: the work forms a theoretical and legal model of ensuring technological sovereignty, which is of strategic importance for the preservation of the Russian Federation sovereignty in its classical understanding as the main and most important feature of the state.Practical significance: the results can be used in law-making activities of public authorities to create legal mechanisms for research, development and implementation of critical and end-to-end technologies and the production of high-tech products based on them in order to ensure national security of the Russian Federation.
Digital Technologies in the National Cadastre System of Uzbekistan: Issues of Legal Regulation
Authors: Toshboyeva R. S. 
Published: November 2024

Objective: to critically analyze the state of national legislation of Uzbekistan in terms of legal regulation of digitalization and the use of artificial intelligence in the cadastral sphere.Methods: the research is based on such methods of scientific cognition as formal-legal and comparative-legal analysis, induction and deduction.Results: the provisions that regulate digitalization and the use of artificial intelligence in the cadastral sphere were analyzed, legal gaps were identified. It was determined that the practical application of artificial intelligence technologies outpaces its legal regulation. The shortcomings of legal regulation in this sphere were noted (lacking legal definition of the legal status of artificial intelligence in the national legislation; regulation of business entities’ participation in the management of artificial intelligence, etc.). The said shortcomings hinder its full application and harmonization with traditional sources of cadastral information. The author substantiated the need for universal digitization of the national cadastre and predicts the possibility of wider application of artificial intelligence in the natural-resource cadastral system. It is argued that the existing system in its current state may lead to wrong decisions and cadastral errors, hence, it is necessary to improve the legal regulation of cadastre.Scientific novelty: for the first time the results of the national cadastre digitization were assessed. Forecasts were given about the possibility of using artificial intelligence in this area, subject to further improvement of legal regulation. The latter is fundamentally important for reforming the cadastral system, since the technological basis of this system does not fully meet the needs of the digital economy.Practical significance: it is due to the lack of legal regulation of the artificial intelligence concept and legal status in the national legislation, as well as a unified approach to the cadastral system digitalization. Modern technologies are actively used in practice, but lack a sufficient legal basis. The main conclusions, proposals and recommendations of the study can be a basis for further improvement of the legal framework of Uzbekistan in terms of the application of artificial intelligence technologies.