bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low‐densityEEG
Authors: Coito Ana , Biethahn Silke , Tepperberg Janina , Carboni Margherita , Roelcke Ulrich , Seeck Margitta , van Mierlo Pieter , Gschwind Markus , Vulliemoz Serge 
Published: March 2019

SummaryObjectiveElectrical source imaging (ESI) is used increasingly to estimate the epileptogenic zone (EZ) in patients with epilepsy. Directed functional connectivity (DFC) coupled toESIhelps to better characterize epileptic networks, but studies on interictal activity have relied on high‐density recordings. We investigated the accuracy ofESIandDFCfor localizing theEZ, based on low‐density clinicalelectroencephalography (EEG).MethodsWe selected patients with the following: (a) focal epilepsy, (b) interictal spikes on standardEEG,(c) either a focal structural lesion concordant with the electroclinical semiology or good postoperative outcome. In 34 patients (20temporal lobe epilepsy [TLE], 14extra‐TLE [ETLE]), we marked interictal spikes and estimated the cortical activity during each spike in 82 cortical regions using a patient‐specific head model and distributed linear inverse solution. DFC between brain regions was computed using Granger‐causal modeling followed by network topologic measures. The concordance with the presumedEZat the sublobar level was computed using the epileptogenic lesion or the resected area in postoperative seizure‐free patients.ResultsESI, summed outflow, and efficiency were concordant with the presumedEZin 76% of the patients, whereas the clustering coefficient and betweenness centrality were concordant in 70% of patients. There was no significant difference betweenESIand connectivity measures. In all measures, patients withTLEhad a significantly higher (P < 0.05) concordance with the presumed EZ than patients with with ETLE. The brain volume accepted for concordance was significantly larger inTLE.SignificanceESI and DFC derived from low‐densityEEGcan reliably estimate theEZfrom interictal spikes. Connectivity measures were not superior toESIforEZlocalization during interictal spikes, but the current validation of the localization of connectivity measure is promising for other applications.
The role of forward‐ and backward‐looking information for inflation expectations formation
Authors: Hubert Paul , Mirza Harun 
Published: March 2019

AbstractAssuming that private forecasters learn inflation dynamics to form their inflation expectations and that they believe a hybrid New Keynesian Phillips curve (NKPC) to capture the true data‐generating process of inflation, we aim at establishing the role of backward‐ and forward‐looking information in the inflation expectation formation process. We find that longer term expectations are crucial in shaping shorter horizon expectations. While the influence of backward‐looking information seems to diminish over time, we do not find evidence of a structural break in the expectation formation process of professional forecasters. Our results further suggest that the weight put on longer term expectations does not solely reflect a mean‐reverting process to trend inflation. Rather, it might also capture beliefs about the central bank's long‐run inflation target and its credibility to achieve inflation stabilization.
Sub‐tephra archaeology and geochemistry at La Arenera, Managua, Nicaragua form a record of human activity before the Asososca Maar eruption of 2130 BP
Authors: Neff Hector , Lange Frederick W. , Kooistra Marty , Caro Carlos , Rankle Chad 
Published: March 2019

AbstractWe recently investigated an occupational surface that lies at the base of a deep deposit of volcanic sand emplaced approximately 2130 years ago in what is now a western suburb of Managua, Nicaragua. LA4, an area of 25 × 18 meters from which overlying sand had been removed by quarrying, was cleaned so that features and artifacts could be point plotted and sediments from the pre‐eruption surface could be sampled. Portable x‐ray fluorescence analysis of surface sediments detected patterns of elemental enrichment that are interpretable as signals of pre‐eruption human activities. The geochemical data combined with feature and artifact distributions support several inferences about how people were using the space on the eve of the 2130 BP volcanic event. A small test excavation confirmed the presence of a shallow but moderately dense primary refuse deposit containing sparse but varied faunal remains, including marine species. The ubiquity of artifact scatters on other exposures of the sub‐tephra surface suggests that the site covers at least 96 hectares, and we speculate that more intact and denser deposits than LA4, possibly including structures and agricultural features, may eventually be encountered.
CASP9 c.‐1339A>G and CASP3 c.‐1191A>G polymorphisms alter susceptibility and clinical aspects of head and neck squamous cell carcinoma
Authors: Costa Ericka Francislaine Dias , Lopes‐Aguiar Leisa , Nogueira Guilherme Silva , Lima Tathiane Regine Penna , Rinck‐Junior José Augusto , Lourenço Gustavo Jacob , Lima Carmen Silvia Passos 
Published: March 2019

AbstractBackgroundSingle nucleotide polymorphisms (SNPs) in genes that act in intrinsic apoptosis pathway may modulate cancer susceptibility. This study investigated the roles of CASP9 c.‐1339A>G (rs4645978) and CASP3 c.‐1191A>G (rs12108497) SNPs on risk and behavior of head and neck (HN) squamous cell carcinoma (SCC).MethodsDNA of 350 patients with HNSCC and 350 controls was analyzed by polymerase chain reaction method for genotyping.Results
CASP3 c.‐1191AG or GG genotype was more common in patients with HNSCC and oral cavity or oropharynx SCC than in controls; carriers of this genotype were under 2.15 and 2.81‐fold increased risks of the respective tumors. CASP9 c.‐1339AG or GG plus CASP3 c.‐1191AG or GG genotypes were associated with oral cavity or oropharynx SCC early onset.ConclusionThese findings present, for the first time, preliminary evidence that inherited abnormalities related to CASP9 c.‐1339A>G and CASP3 c.‐1191A>G SNPs are determinants of HNSCC risk and clinical aspects.
Association of the LiveLighter mass media campaign with consumption of sugar‐sweetened beverages: Cohort study
Authors: Morley Belinda , Niven Philippa , Dixon Helen , Swanson Maurice , Szybiak Maria , Shilton Trevor , Pratt Iain S. , Slevin Terry , Wakefield Melanie 
Published: March 2019

AbstractIssue addressedEvaluation of the behavioural impact of Western Australia's LiveLighter healthy weight and lifestyle campaign focussed on decreasing consumption of sugar‐sweetened beverages (SSBs) using graphic imagery, as well as monitoring unintended consequences.MethodsA cohort design with pre‐campaign telephone survey of Western Australian adults aged 25‐49 (Time 1 May/Jun 2013: N = 1504) undertaken and repeated following the campaign (Time 2 Aug/Sep 2013: N = 822).ResultsPost‐campaign awareness was 67% with respondents in low socio‐economic areas most likely to report viewing the campaign frequently. There was evidence of reduced SSB intake from baseline to follow‐up among frequent (4+/week) SSB consumers (22% cf. 16%; P = 0.003) and some evidence among overweight (BMI 25+) weekly SSB consumers (56% cf. 48%; P = 0.013). There was also some evidence consumption of sweet food decreased (3+/week: 53% cf. 48%; P = 0.035) while fruit, vegetable and fast food consumption remained stable. Knowledge of potential health consequences of SSBs increased (70% cf. 82%; P < 0.001) with no change in knowledge of potential health consequences of overweight generally (86% cf. 89%). Importantly, there was no increase in endorsement of overweight stereotypes.ConclusionsThe LiveLighter “Sugary Drinks” campaign positively impacted adults’ knowledge and behaviour with regard to SSB consumption in a pattern specific to the campaign messaging and without adverse impact on weight‐related stereotypes.So what?Findings support the use of mass media for healthy lifestyle change. They suggest the public are receptive to undertaking the campaign's simple concrete lifestyle recommendation and provide an indication of the campaign dose required to achieve positive behaviour change.
Abatement of dimethyl sulfide using anoxic biotrickling filter
Authors: Shihab Mohammed Salim , Akmirza Ilker , Mhemid Rasha Khalid , Türker Mustafa , Alp Kadir 
Published: March 2019

AbstractBACKGROUNDThis study aimed to use a lab‐scale anoxic biotrickling filter (ABTF) for the bioconversion of dimethyl sulfide (DMS) gas to produce less harmful byproducts, i.e. elemental sulfur and/or sulfate. It examined the exploitation of nitrate as an electron acceptor in the oxidation of malodorous DMS‐containing gas in combination with other parameters: gas/liquid (G/L) ratio (40, 60, 80, 100, 150), empty bed residence time (EBRT) (10, 30, 60, 90, 120 s) and inlet loading (IL) (9, 18, 48, 90 g m−3 h−1).RESULTSThermodynamic analysis and half‐reactions showed that at DMS/NO3− molar yield ratios 0.75 and 0.34, elemental sulfur and sulfate were the main metabolic products respectively. Overall, 58% of the sulfur element in DMS was bioconverted to elemental sulfur. Mass balance calculations revealed high denitrification efficiency, i.e. 52.7% of inlet NO3− was converted to N2. The optimal EBRT was found as 30 s (corresponding to removal efficiency (RE) 89%) for inlet concentration 150 mg m−3 and as 60 s (corresponding to RE 78%) for inlet concentration 1500 mg m−3. However, the maximum elimination capacity (EC) was 70.3 g m−3 h−1 at EBRT 60 s and G/L ratio 80. The relative abundance of bacterial communities was dominated by Proteobacteria (56.1%) and Alphaproteobacteria (27.3%) at phylum and class levels respectively.CONCLUSIONThe study revealed that ABTF has a reliable biodegradation capacity in DMS oxidation under anoxic conditions; however, process improvement on mass transfer enhancement for low waste gas concentrations is still required. © 2019 Society of Chemical Industry
Modeling of bidding strategies in a competitive electricity market: A hybrid approach
Authors: Senthilvadivu A , Gayathri K , Asokan K 
Published: March 2019

AbstractIn the paper, an innovative hybrid algorithm is proposed to solve bidding strategy problem in electricity market. The proposed hybrid technique is the combination of the recurrent neural network (RNN), support vector machine (SVM), and the lightning search algorithm (LSA). The main contribution of this paper is to maximize the profits of suppliers and minimize the customer payments; it is very important to create reasonable matching rule for the electricity market. LSA optimizes bidding coefficients of both the suppliers and consumers with the consideration of available power generation limit, power demand, market‐clearing price (MCP), and constraints. RNN is utilized for demand prediction at every hour, and SVM ensures the MCP based on the demand. The proposed bidding strategy ensures the maximum profit of the suppliers and consumers because of the aggregated demand model. The proposed method is tested on The Institute of Electrical and Electronics Engineers (IEEE) 30‐bus system and 75‐bus Indian practical system and compared with the existing techniques. The comparison results demonstrate the superiority of the proposed technique and confirm its potential to solve the problem. Also, the proposed model and the strategies are implemented in the MATLAB, and the performance will be studied under various demand environments.
It worked there, so it should work here: Sustaining change while improving product development processes
Authors: Collins Shawn T. , Browning Tyson R. 
Published: March 2019

AbstractOrganizations operate under ongoing pressure to conduct product development (PD) in ways that reduce errors, improve product designs, and increase speed and efficiency. Often, managers are expected to respond to this pressure by implementingprocess improvement programs(PIPs) based on best practices elsewhere (e.g., in another part of their organization or in another industrial context). Successful PIP implementation depends on two criteria: (a) demonstrating (symbolic) success by meeting externally imposed deadlines and producing mandated artifacts and (b) sustaining the expected (substantive) changes in their employees' underlying beliefs and practices. Given the mixed success of PIPs in nonmanufacturing contexts, identifying factors that contribute to both symbolic and substantive implementation is important to both researchers and practitioners. We explore this challenge through an in‐depth field study at a PD company (DevCo) that implemented a PIP across its 11 PD projects. We examine DevCo's change message to implement the PIP, how DevCo's engineers experienced it, factors that impeded implementation, and factors that could improve substantive success. Along with this empirical evidence, we leverage organizational change concepts to facilitate effective PIP implementation in new contexts such as PD. We distill our findings into eight propositions that expand theory about effectively transferring PIPs across contexts.
Black and white box: Take good gross pathology photographs
Authors: García‐Alvarez Ciro , Sánchez‐Tabernero Sara , García‐Lagarto Elena , Saornil Maria A. 
Published: March 2019

AbstractMacroscopic study of surgical samples sent to the histopathology lab provides the first diagnostic approach. Obtaining quality photographs of these pieces facilitates proper case documentation for publication, sharing, teaching and research.This device has been originally designed for enucleated eyes but it could be used for a wide diversity of human or animal samples including thyroids, pituitary glands, prostates… It can be coupled to any smartphone camera.The Black and White Box is an affordable and easy option for taking gross pathology photographs of high quality. In this work we provide full instructions on how to make it.
Resveratrol alleviate the injury of mice liver induced by cadmium sulfide nanoparticles
Authors: Meng Chun‐Yan , Han Ya‐Feng , Liu Ying‐Li , Gao Hong‐Xia , Ren Yi‐Yi , Qian Qing‐Zeng , Wang Qian , Li Qing‐Zhao 
Published: March 2019

AbstractCadmium sulfide nanoparticle (Nano‐CdS) is a kind of important semiconductor material with special photochemistry property. With the Nano‐CdS being widely used, the security problems it caused have been catching more and more attention. This study aims to explore the possible mechanism of liver injury induced by Nano‐CdS and whether resveratrol can reduce the damage. In this study, male BALB/C mice were treated with Nano‐CdS with a diameter of 20 to 30 nm and a length of 80 to 100 nm. It turned out that the mice liver inflammatory cells infiltrated, the liver tissue and the ultrastructure changed; The activities of T‐AOC and GSH were suppressed (n = 6, P < 0.05) and the content of lipid peroxide (MDA) increased (n = 6, P < 0.05). Besides, Nano‐CdS decreased the mRNA expression level of Sirt1 and FoxO1 genes in liver tissue (n = 3, P < 0.05). All the changes in the index were reversed by resveratrol. The mRNA expression level of FoxO3a showed no significant difference between the control group and the Nano‐CdS group. But under the protection of resveratrol, the mRNA expression level of FoxO3a was higher than that in the control and Nano‐CdS groups (n = 3, P < 0.05). Results suggest that Nano‐CdS can cause oxidative damages to liver tissues in mice, in which process that the Sirt1 and FoxO1 genes may participate, and the damage can be reversed by resveratrol which may be a potential cure for oxidative damage to nanomaterials.
Overexpression of CMTM7 inhibits cell growth and migration in liver cancer
Authors: Huang Zi‐Ming , Li Peng‐Ling , Yang Peng , Hou Xiao‐Dan , Yang Yi‐Li , Xu Xin , Xu Feng 
Published: March 2019

AbstractChemokine‐like factor (CKLF)‐like, MAL and related proteins for vesicle trafficking and membrane link (MARVEL) transmembrane domain‐containing family proteins (CMTMs) have significant roles in the immune system, in male reproduction, as well as in tumorigenesis. Previous studies have shown that CMTM family member 7 (CMTM7) was broadly expressed in various normal tissues, but not in lung, gastric, esophageal, pancreas, and cervix cancers. To explore its relationship with liver cancer, we examined the expression of CMTM7 in liver cancers and its correlation with clinical and pathological conditions. We found that CMTM7 expression was markedly reduced in liver cancer tissues, and negatively correlated with TNM staging and tumor metastasis. In vitro studies showed that enforced expression of CMTM7 inhibited the cell growth and migration of liver cancer cells. Further analysis revealed that CMTM7 suppressed AKT signaling and induced cell cycle arrest at the G0/G1 phase in the liver cancer cells, likely as the consequent of decreased levels of cyclin D1, cyclin‐dependent kinase 4 (CDK4), and CDK6, and increased p27 expression. Thus, CMTM7 functions as a tumor suppressor in liver cancer through suppressing cell cycle progression.
Chronic laryngitis caused by Mycobacterium Kansasii in a traveler
Authors: Lehman Bethany , Procop Gary W. , Silva Merea Valeria , Harrington Susan M. , Mawhorter Steven D. , Benninger Michael S. 
Published: March 2019

Chronic laryngitis commonly presents with dysphonia, and infectious causes include tuberculosis and endemic mycoses. We present a 58‐year‐old female with laryngitis for 5 years, fevers, chills, fatigue, malaise, myalgias, anterior neck pain, and night sweats after multicontinent exposure. Bronchoscopy cultures were negative. Bilateral microflap excision of vocal fold lesions demonstrated thickened epithelium and a deep vocal fold mass. Biopsy showed necrotizing granulomatous inflammation with acid‐fast bacilli. Mycobacterium kansasii was identified. Treatment led to improvement in dysphonia, systemic symptoms, and vocal fold irritation. To our knowledge, this is the first case of isolated nontuberculous mycobacterial vocal fold infection.Laryngoscope, 129:2534–2536, 2019
The Effects of Different Winter Feeding Regimens on Growth, Survival, and Fatty Acid Composition of Fathead Minnow and Golden Shiners
Authors: Roy Luke A , Rawles Steven D , Kelly Anita M , Stone Nathan , Park Jeonghwan , Webster Carl D 
Published: March 2019

Abstract
Winter mortality is a common problem for Arkansas baitfish farmers that produce Fathead Minnow (FHM) Pimephales promelas and Golden Shiners (GS) Notemigonus crysoleucas. Winter feeding programs are a potential avenue to improve survival and condition and reduce weight loss of baitfish. Methods of winter feeding vary widely among producers, and currently there are no recognized best management practices. The impacts of different winter feeding regimens on FHM and GS survival, growth, and lipid storage were evaluated in temperature-controlled aquarium systems. Fathead Minnow (mean ± SD = 0.88 ± 0.04 g) or GS (0.88 ± 0.02 g) were stocked at ambient water temperature, and the temperature was reduced to 6°C (FHM) or 8°C (GS) to mimic winter conditions. Three feeding regimens were implemented (3 tanks/regimen) that included ad libitum feeding twice per week (2×/week), once per week (1×/week), or once per month (1×/month). Significant differences in weight gain (loss), condition factor (K), and specific growth rate were observed after 13 weeks for FHM. Fish that were fed 2×/week gained nearly 3%, while fish that were fed 1×/week or 1×/month lost weight (2.3% and 10.1%, respectively). There were no significant differences in GS final weight (0.79–0.82 g), survival (65.0–88.3%), or weight gain (−6.84% to −9.50%) among treatments after 12 weeks. The GS from the 2×/week treatment had significantly higher K-values than GS that were fed 1×/week or 1×/month. Fatty acid profiles of both species differed among treatments, showing a decline in saturated fatty acids from initial levels and an increase in polyunsaturated fatty acids (PUFAs) as feeding frequency decreased. Results suggest that fish may lose weight during the winter, but it does not appear to adversely affect survival, and both species alter their fatty acid compositions to optimize n-3 PUFAs during cold water temperatures.
Analysis of Liver Proteome and Identification of Critical Proteins Affecting Milk Fat, Protein, and Lactose Metabolism in Dariy Cattle with iTRAQ
Authors: Xu Lingna , Shi Lijun , Liu Lin , Liang Ruobing , Li Qian , Li Jianguo , Han Bo , Sun Dongxiao 
Published: March 2019

AbstractIn this study, the proteomes of liver tissues are investigated in three periods of the lactation cycle of Holstein cows by using isobaric tag for relative and absolute quantification (iTRAQ) technique to obtain liver proteome and identify functional proteins/genes involved in milk synthesis in dairy cattle. Based on iTRAQ analysis, 3252 proteins are detected in the liver tissues (false discovery rate ≤0.01). Thirty‐two differently expressed proteins (DEPs) are identified during the three periods by p‐value <0.05 and fold change (FC) ≥2 or ≤0.5, and 183 DEPs based on p‐value <0.05 and FC ≥1.5 or ≤0.67. In addition, 905 DEPs are obtained across the three periods by p‐value <0.05 and FC ≥1.2, or ≤0.83, and the subsequent GO and KEGG pathway functional analysis indicate that 73 DEPs are significantly enriched into the metabolic terms and pathways involved in milk synthesis such as citrate cycle, fatty acid, starch and sucrose metabolism, and mTOR and PPAR signaling pathways. Further, 41 out of 73 DEPs are identified near to both the peak locations of the reported quantitative trait locus and significant single nucleotide polymorphisms that associate with milk yield and composition traits. In addition, the 41 DEPs are analyzed with the previous liver transcriptome data that used the same samples as this study, and considered nine proteins/genes—ALDH18A1, APOA4, CYP7A1, HADHB, PRKACA, IDH2, LDHA, LDHB, and MAT2A—to be the promising candidates for milk fat, protein, and lactose synthesis in dairy cattle. This study provides a new vision for identifying the potential critical genes associated with milk synthesis of dairy cattle.