bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrent Mild Traumatic Brain Injury and Posttraumatic Stress Disorder Is Associated With Elevated Tau Concentrations in Peripheral Blood Plasma
Authors: Pattinson Cassandra L. , Gill Jessica M. , Lippa Sara M. , Brickell Tracey A. , French Louis M. , Lange Rael T. 
Published: July 2019

AbstractConcurrent mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) are common in U.S. military service members and veterans. Tau and amyloid‐beta‐42 (Aβ42) are proteins that have been linked to cognitive impairment, neurological hallmarks of Alzheimer's disease, and may also relate to recovery from mTBI. However, the role of these proteins in the maintenance or resolution of chronic symptoms has not yet been determined. Participants in the current study were 102 service members and veterans who had sustained an mTBI (n = 84) or injured controls (IC) without TBI (n = 18). They were categorized into three groups based on the presence or absence of mTBI and PTSD: IC/PTSD‐Absent (n = 18), mTBI/PTSD‐Absent (n = 63), and mTBI/PTSD‐Present (n = 21). Concentrations of tau and Aβ42 in peripheral blood plasma were measured using SimoaTM, an ultrasensitive technology, and compared across groups. Tau concentrations were highest in the mTBI/PTSD‐Present group, F(2, 99) = 4.33, p = .016, compared to the other two groups. Linear multiple regression was conducted to determine the independent effects of PTSD and mTBI on tau concentrations, controlling for gender and sleep medication. PTSD was a significant and independent predictor of tau concentrations, β = .25, p = .009, ηp2 = .26. Aβ42 concentrations did not differ between the groups. The results indicated that PTSD was associated with an elevation of tau in peripheral blood and suggest that there may be increased biological effects of PTSD in this young cohort of service members and veterans following mTBI.
Evaluation of water and land exploitation based on the ecosystem service value in a hyper‐arid region with intensifying basin management
Authors: Ling Hongbo , Yan Junjie , Guo Bin , Xu Hailiang , Li Xuemei , Deng Xiaoya 
Published: July 2019

AbstractEffective management is crucial for coordinating the conflict between environment protection and water and land exploitation. Changes in ecosystem service value (ESV) can be used to evaluate the gains and losses of the exploitation in a comprehensive way. Solutions to the following problems will facilitate the incorporating of ESV to the management of arid basin and improve the effectiveness. (a) How to improve the response sensitivity of ESV to the changes in water and land use, (b) how to determine the sustainable approach to land use/exploitation, and (c) how to ascertain the tipping point in the scale of water and land exploitation. In this research, key factors of vegetation cover, human disturbance, and soil drought were selected as the driving factors for the changes in ESV and incorporated in the ESV calculation. The approach enhanced the expression of the spatial heterogeneity in ESV as well as its response sensitivity to changes in the environment. As the management improved in the basin, the benefits of water and land exploitation increased gradually. An appropriate model of natural vegetation protection and exploitation was developed based on ESV produced by per cubic meter of ecological water requirement. Furthermore, the tipping point in the scale of water and land exploitation can be identified by the turning point in the fluctuations of the ESV. The results provide not only a new approach for formulating sustainable land development program in arid basins but also a scientific reference for making timely adjustments in land development strategies.
Extracellular superoxide production by key microbes in the global ocean
Authors: Sutherland Kevin M. , Coe Allison , Gast Rebecca J. , Plummer Sydney , Suffridge Christopher P. , Diaz Julia M. , Bowman Jeff S. , Wankel Scott D. , Hansel Colleen M. 
Published: July 2019

ABSTRACTBacteria and eukaryotes produce the reactive oxygen species superoxide both within and outside the cell. Although superoxide is typically associated with the detrimental and sometimes fatal effects of oxidative stress, it has also been shown to be involved in a range of essential biochemical processes, including cell signaling, growth, differentiation, and defense. Light‐independent extracellular superoxide production has been shown to be widespread among many marine heterotrophs and phytoplankton, but the extent to which this trait is relevant to marine microbial physiology and ecology throughout the global ocean is unknown. Here, we investigate the dark extracellular superoxide production of five groups of organisms that are geographically widespread and represent some of the most abundant organisms in the global ocean. These include Prochlorococcus, Synechococcus, Pelagibacter, Phaeocystis, and Geminigera. Cell‐normalized net extracellular superoxide production rates ranged seven orders of magnitude, from undetectable to 14,830 amol cell−1 h−1, with the cyanobacterium Prochlorococcus being the lowest producer and the cryptophyte Geminigera being the most prolific producer. Extracellular superoxide production exhibited a strong inverse relationship with cell number, pointing to a potential role in cell signaling. We demonstrate that rapid, cell‐number–dependent changes in the net superoxide production rate by Synechococcus and Pelagibacter arose primarily from changes in gross production of extracellular superoxide, not decay. These results expand the relevance of dark extracellular superoxide production to key marine microbes of the global ocean, suggesting that superoxide production in marine waters is regulated by a diverse suite of marine organisms in both dark and sunlit waters.
The role of high‐intensity focused ultrasound as a symptomatic treatment for Parkinson's disease
Authors: Moosa Shayan , Martínez‐Fernández Raul , Elias W. Jeffrey , del Alamo Marta , Eisenberg Howard M. , Fishman Paul S. 
Published: July 2019

AbstractMR‐guided focused ultrasound is a novel, minimally invasive surgical procedure for symptomatic treatment of PD. With this technology, the ventral intermediate nucleus, STN, and internal globus pallidus have been targeted for therapeutic cerebral ablation, while also minimizing the risk of hemorrhage and infection from more invasive neurosurgical procedures. In a double‐blinded, prospective, sham‐controlled randomized controlled trial of MR‐guided focused ultrasound thalamotomy for treatment of tremor‐dominant PD, 62% of treated patients demonstrated improvement in tremor scores from baseline to 3 months postoperatively, as compared to 22% in the sham group. There has been only one open‐label trial of MR‐guided focused ultrasound subthalamotomy for patients with PD, demonstrating improvements of 71% for rigidity, 36% for akinesia, and 77% for tremor 6 months after treatment. Among the two open‐label trials of MR‐guided focused ultrasound pallidotomy for patients with PD, dyskinesia and overall motor scores improved up to 52% and 45% at 6 months postoperatively. Although MR‐guided focused ultrasound thalamotomy is now approved by the U.S. Food and Drug Administration for treatment of parkinsonian tremor, additional high‐quality randomized controlled trials are warranted and are underway to determine the safety and efficacy of MR‐guided focused ultrasound subthalamotomy and pallidotomy for treatment of the cardinal features of PD. These studies will be paramount to aid clinicians to determine the ideal ablative target for individual patients. Additional work will be required to assess the durability of MR‐guided focused ultrasound lesions, ideal timing of MR‐guided focused ultrasound ablation in the course of PD, and the safety of performing bilateral lesions. © 2019 International Parkinson and Movement Disorder Society
Measuring Parkinson's disease over time: The real‐world within‐subject reliability of the MDS‐UPDRS
Authors: Evers Luc J.W. , Krijthe Jesse H. , Meinders Marjan J. , Bloem Bastiaan R. , Heskes Tom M. 
Published: July 2019

AbstractBackgroundAn important challenge in Parkinson's disease research is how to measure disease progression, ideally at the individual patient level. The MDS‐UPDRS, a clinical assessment of motor and nonmotor impairments, is widely used in longitudinal studies. However, its ability to assess within‐subject changes is not well known. The objective of this study was to estimate the reliability of the MDS‐UPDRS when used to measure within‐subject changes in disease progression under real‐world conditions.MethodsData were obtained from the Parkinson's Progression Markers Initiative cohort and included repeated MDS‐UPDRS measurements from 423 de novo Parkinson's disease patients (median follow‐up: 54 months). Subtotals were calculated for parts I, II, and III (in on and off states). In addition, factor scores were extracted from each part. A linear Gaussian state space model was used to differentiate variance introduced by long‐lasting changes from variance introduced by measurement error and short‐term fluctuations. Based on this, we determined the within‐subject reliability of 1‐year change scores.ResultsOverall, the within‐subject reliability ranged from 0.13 to 0.62. Of the subscales, parts II and III (OFF) demonstrated the highest within‐subject reliability (both 0.50). Of the factor scores, the scores related to gait/posture (0.62), mobility (0.45), and rest tremor (0.43) showed the most consistent behavior.ConclusionsOur results highlight that MDS‐UPDRS change scores contain a substantial amount of error variance, underscoring the need for more reliable instruments to forward our understanding of the heterogeneity in PD progression. Focusing on gait and rest tremor may be a promising approach for an early Parkinson's disease population. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Acute renal impairment characterization using diffusion magnetic resonance imaging: Validation by histology
Authors: Yu Zhixian , Zhu Honghui , Wu Xiuling , Chen Zhongwei , Zhang Zhao , Li Jiance , Ye Qiong 
Published: July 2019

Diffusion magnetic resonance imaging has been demonstrated to be a simple, noninvasive and accurate method for the detection of renal microstructure and microcirculation, which are closely linked to renal function. Moreover, serum endothelin‐1 (ET‐1) was also reported as a good indicator of early renal injury.The aim of this study was to evaluate the feasibility and capability of diffusion MRI and ET‐1 to detect acute kidney injury by an operation simulating high‐pressure renal pelvic perfusion, which is commonly used during ureteroscopic lithotripsy. Histological findings were used as a reference. Fourteen New Zealand rabbits in an experimental group and 14 in a control group were used in this study. Diffusion tensor imaging and intravoxel incoherent motion diffusion‐weighted imaging were acquired by a 3.0 T MRI scanner.Significant corticomedullary differences were found in the values of the apparent diffusion coefficient (ADC), pure tissue diffusion, volume fraction of pseudo‐diffusion (fp) and fractional anisotropy (FA) (P < 0.05 for all) in both preoperation and postoperation experimental groups. Compared with the control group, the values of cortical fpmean, medullary ADCmean and FAmean decreased significantly (P < 0.05) after the operation in the experimental group. Also, the change rate of medullary ADCmean in the experimental group was more pronounced than that in the control group (P = 0.018). No significant change was found in serum ET‐1 concentration after surgery in either the experimental (P = 0.80) or control (P = 0.17) groups. In the experimental group, histological changes were observed in the medulla, while no visible change was found in the cortex.This study demonstrated the feasibility of diffusion MRI to detect the changes of renal microstructure and microcirculation in acute kidney injury, with the potential to evaluate renal function. Moreover, the sensitivity of diffusion MRI to acute kidney injury appears to be superior to that of serum ET‐1.
Transcendental Bernstein series for solving reaction–diffusion equations with nonlocal boundary conditions through the optimization technique
Authors: Avazzadeh Zakieh , Hassani Hossein 
Published: July 2019

AbstractIn this paper, we apply transcendental Bernstein series (TBS) for solving reaction–diffusion equations with nonlocal boundary conditions which is the novel approximation tool. To carry out the method, we firstly expand the solution of the system in the term of TBS through the operational matrix scheme. To determine the unknown free coefficients and control parameters appeared in TBS expansion, we define an optimization problem which combines the reaction–diffusion equation with its nonlocal boundary conditions. Then we use the Lagrange multipliers technique for converting the problem under study into a system of algebraic equations. High accuracy and simplicity in reducing the integral boundary conditions are some privileges of the proposed scheme. We emphasize that Bernstein polynomials is the particular case of transcendental Bernstein series. Theoretical discussion about convergence confirms the reliability of the proposed method. Some test problems are chosen to investigate the applicability and computational efficiency. The experimental results confirm that the obtained results are in good agreement with the exact solutions with high rate of convergence.
Sharing What Can Be Sold: WomenHaus MaketVendors in Port Moresby's Settlements
Authors: Rooney Michelle Nayahamui 
Published: July 2019

ABSTRACTDominant narratives of the economy, as well as policy discourses in Papua New Guinea (PNG), tend to separate the ‘formal’ from the ‘informal’ economy. Concurrently, there is a development policy emphasis on women's economic empowerment. In urban areas this has meant a policy focus on larger market places as sites where women need support for economic engagement. Within these policy discourses, one activity in urban areas usually relegated to the ‘informal’ economy is small home‐based market stalls, referred to in this paper ashaus maket. Located at homes or on nearby roads,haus maketare prolific and available to the public, and as such provide a similar function to public market places as spaces to make money. This paper considers these public yet intimate spaces as sites where vendors, usually women, embody and lead contestations between money and moral value spheres. At a time when the policy emphasis is on the formal economy and larger market places in PNG, why do such small market places persist? The first aim of this paper is to establish the role ofhaus maketas a site where spheres of value intersect. Rather than being ‘informal’ and peripheral, I seek to foreground its centrality to the economy but also as a site where economic and social moral values conflate. The second aim of the paper is to examine the role of sharing as a form of transaction in its own right distinct from exchange as a transaction between two actors.Haus maketstalls are sites of sharing and of moral action and value where forms of value in the settlement are shaped and negotiated.
Marketplaces and Morality in Papua New Guinea: Place, Personhood and Exchange
Authors: Busse Mark , Sharp Timothy L. M. 
Published: July 2019

ABSTRACTIn Papua New Guinea (PNG) more rural people, and especially rural women, earn cash from selling in marketplaces than from any other source. PNG's marketplaces are critical for food security, and for the redistribution of wealth. They are also important meeting places where people gather to see friends, hear the latest news, attend court cases, play cards and be entertained. This introduction to this special issue on ‘Marketplaces and Morality in Papua New Guinea’ reviews the history of PNG marketplaces and their contemporary forms. It charts their transformation from introduced colonial spaces into dynamic Melanesian places, which, as places to buy, sell and socialise, have become pervasive institutions in the lives of both urban and rural Papua New Guineans, and places where people interact with both known and unknown others. From this, marketplaces emerge as important spaces of moral evaluation and contestation in relation to what constitutes morally acceptable exchange and what practices are acceptable in these places. The paper demonstrates that exchange in the marketplace should not be reduced to commodity transactions, and questions assumptions about the types of people marketplaces create. It argues that the country's marketplaces are productive sites to consider ideas of exchange, social relations and social personhood, and that there is a critical need to understand the concrete details of what takes place in contemporary marketplaces.
Morality and the Concept of the Market Seller among Gehamo
Authors: Busse Mark 
Published: July 2019

ABSTRACTThis paper examines the negative moral evaluations of people who buy and resell fresh food by Gahuku and Gehamo people in and around Goroka, the capital of Eastern Highlands Province, Papua New Guinea. During my fieldwork from 2010 to 2015, vendors in the Goroka fresh food market argued that the value of fresh food should be based on the work that people did to produce it rather than on price competition, or on supply and demand. An examination of market vendors’ practice of ‘giving extra’ to customers, and the responses of vendors who resold food to negative moral evaluations of their activities, led me to an examination of the morality of production in relation to land, ancestors, and social relations; the morality of the marketplace; as well as ideas about what makes someone a good social person. Drawing on Erik Schwimmer's (1979) discussion of the concept of work in Melanesian societies, I argue that vendors in the Goroka market continue to emphasize use value and their own identification with the food that they are selling rather than the exchange value of alienated produce. While marketplaces are the apparent locus par excellence of capitalist economic activity, a consideration of the morality of Goroka market vendors leads to the caution that just because one sees something that looks like a marketplace in which people are engaging in commodity transactions does not necessarily mean that it is a marketplace in which people are engaging in commodity transactions. Similarly, just because something looks like a price does not necessarily mean that it is a price. Those considerations, in turn, lead to a re‐examination of Kenneth Read's (1955) characterization of morality and personhood among Gahuku in light of contemporary market exchange.
Strategies to Improve/Eliminate the Limitations in Shotgun Lipidomics
Authors: Hu Changfeng , Duan Qiao , Han Xianlin 
Published: July 2019

AbstractDirect infusion‐based shotgun lipidomics is one of the most powerful and useful tools in comprehensive analysis of lipid species from lipid extracts of various biological samples with high accuracy/precision. However, despite many advantages, the classical shotgun lipidomics suffers some general dogmas of limitations, such as ion suppression, ambiguous identification of isobaric/isomeric lipid species, and ion source–generated artifacts, restraining the applications in analysis of low‐abundance lipid species, particularly those less ionizable or isomers that yield almost identical fragmentation patterns. This article reviews the strategies (such as modifier addition, prefractionation, chemical derivatization, charge feature utilization) that have been employed to improve/eliminate these limitations in modern shotgun lipidomics approaches (e.g., high mass resolution mass spectrometry–based and multidimensional mass spectrometry–based shotgun lipidomics). Therefore, with the enhancement of these strategies for shotgun lipidomics, comprehensive analysis of lipid species including isomeric/isobaric species is achieved in a more accurate and effective manner, greatly substantiating the aberrant lipid metabolism, signaling trafficking, and homeostasis under pathological conditions.
The predictive role of self‐compassion in cancer patients' symptoms of depression, anxiety, and fatigue: A longitudinal study
Authors: Zhu Lei , Yao Juntao , Wang Jun , Wu Liyang , Gao Yuhan , Xie Juan , Liu Ailan , Ranchor Adelita V. , Schroevers Maya J. 
Published: July 2019

AbstractObjectiveSelf‐compassion is consistently found to be related to better psychological outcomes. As most studies were cross‐sectional, little is known about the predictive role of self‐compassion for future psychological outcomes. This longitudinal study in cancer patients investigated the predictive role of self‐compassion at the time of cancer diagnosis for the course of symptoms of depression, anxiety, and fatigue in the period of receiving cancer treatment.MethodsThis longitudinal study was conducted at the Shaanxi Provincial Tumour Hospital in Xi'an, China. A total of 153 heterogeneous cancer patients were assessed within 1 week after cancer diagnosis (T1) as well as at the start (T2) and the end (T3) of medical treatment. Hierarchical linear regression analyses were conducted to examine the research questions.ResultsCross‐sectional regression analyses at T1 showed that a self‐compassion total score and negative self‐compassion (and to a lesser extent positive self‐compassion) were significantly related to symptoms of depression, anxiety, and fatigue. When controlling for symptoms at T1, positive self‐compassion significantly predicted all three outcomes at T3. A self‐compassion total score only predicted symptoms of anxiety at T2, controlling for T1 symptoms. In contrast, we found no significant predictive value of negative self‐compassion.ConclusionsThis study suggests that the positive aspects of self‐compassion are beneficial for cancer patients for their future functioning, in terms of fewer symptoms of depression, anxiety, and fatigue over time. Future interventions should test how and to what extent self‐compassion can be cultivated and whether increases in self‐compassion are associated with better outcomes.