bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single‐incision laparoscopic surgery using the glove technique with improved maneuverability achieved through fulcrum creation via a simple ring technique
Authors: Yoshida Makoto , Oshiro Takafumi , Fukuda Toshikatsu , Yano Masatsugu , Ochi Makoto , Okamoto Yuzo , Ono Eiji , Ohdan Hideki 
Published: March 2019

IntroductionSingle‐incision laparoscopic surgery (SILS) is widely used in many surgical procedures in various specialties. Among the access methods used in SILS, the glove technique, which is typically similar to the multi‐trocar approach, is simple, convenient, and inexpensive. However, given the absence of a fulcrum supporting the endoscopic surgical forceps, the technique is less advantageous than methods using commercially available access devices because of the poor maneuverability of the forceps.Materials and Surgical TechniqueBy creating a fulcrum as a support to use with existing surgical forceps in the glove technique, we designed and used a novel method known as the “ring technique.” This technique aimed to improve the maneuverability of endoscopic surgical forceps.DiscussionPlacing a fulcrum resulted in the improvement of the forceps' maneuverability, which helped to ameliorate a weakness of the glove technique. The ring technique could be a useful option as a method of access in SILS.
Single‐incision laparoscopic reversal of Hartmann's operation through the stoma site: comparative outcomes with conventional laparoscopic and open surgery
Authors: Thambi P. , Borowski D. W. , Sathasivam R. , Obuobi R.‐B. , Viswanath Y. K. S. , Gill T. S. 
Published: March 2019

AbstractAimRestoration of bowel continuity after Hartmann's procedure (RoH) can be challenging and associated with considerable morbidity. A technique using single‐incision laparoscopic surgery through the stoma site (SIL RoH) has been shown to be feasible and safe. In this study, we compared clinical outcomes of SIL RoH with conventional laparoscopic surgery (CL) and open surgery (OS).MethodsThis was a retrospective analysis of a prospectively maintained database between 2007 and 2017 in a UK colorectal unit. The access technique was decided by the surgeon on a case by case basis.ResultsA total of 106 patients underwent RoH. It was carried out for diverticular disease (n = 71, 67.6%), cancer (n = 19, 17.9%) and anastomotic leak (n = 4, 3.8%). The remainder (n = 12, 11.3%) were for miscellaneous reasons including trauma. Most RoHs were performed via OS (n = 87, 81.1%). The most common intended approaches for RoH were SIL (n = 56, 52.8%) and OS (n = 34, 32.1%) with fewer starting with CL (n = 16, 15.1%). Conversion to OS took place in five (8.9%) patients with SIL and six (37.5%) with CL (P = 0.005). Postoperative complications occurred in 17 (30.4%) for SIL, seven (43.8%) for CL and 17 (50.0%) for OS (P = 0.162). Median operating time for SIL was 146 min (range 44–389), 211 min (109–320) for CL and 211 min (85–420) for OS (P < 0.001). Median length of stay was 4 days (2–44) for SIL compared to 6 (3–34) for CL and 7 (4–34) for OS (P < 0.001). Discharge on or before day 5 was achieved in 41 (74.5%) patients for SIL compared to six (37.5%) for CL and seven (20.6%) for OS (P < 0.001).ConclusionCompared to OS and CL, SIL RoH appears to have shorter operating times and hospitalization, with no discernible difference in morbidity; this finding requires further evaluation in a randomized setting.
Single cell‐derived clonally expanded mesenchymal progenitor cells from somatic cell nuclear transfer‐derived pluripotent stem cells ameliorate the endometrial function in the uterus of a murine model with Asherman’s syndrome
Authors: Jun Sung‐Min , Park Mira , Lee Ji Yoon , Jung Sookyung , Lee Jeoung Eun , Shim Sung Han , Song Haengseok , Lee Dong Ryul 
Published: March 2019

AbstractObjectivesBecause primary mesenchymal progenitor cells (adult‐MPCs) have various functions that depend on the tissue origin and donor, de novo MPCs from human pluripotent stem cells (hPSCs) would be required in regenerative medicine. However, the characteristics and function of MPCs derived from reprogrammed hPSCs have not been well studied. Thus, we show that functional MPCs can be successfully established from a single cell‐derived clonal expansion following MPC derivation from somatic cell nuclear transfer‐derived (SCNT)‐hPSCs, and these cells can serve as therapeutic contributors in an animal model of Asherman's syndrome (AS).Materials and methodsWe developed single cell‐derived clonal expansion following MPC derivation from SCNT‐hPSCs to offer a pure population and a higher biological activity. Additionally, we investigated the therapeutic effects of SCNT‐hPSC‐MPCs in model mice of Asherman's syndrome (AS), which is characterized by synechiae or fibrosis with endometrial injury.ResultsTheir humoral effects in proliferating host cells encouraged angiogenesis and decreased pro‐inflammatory factors via a host‐dependent mechanism, resulting in reduction in AS. We also addressed that cellular activities such as the cell proliferation and population doubling of SCNT‐hPSC‐MPCs resemble those of human embryonic stem cell‐derived MPCs (hESC‐MPCs) and are much higher than those of adult‐MPCs.ConclusionsSomatic cell nuclear transfer‐derived‐hPSCs‐MPCs could be an advanced therapeutic strategy for specific diseases in the field of regenerative medicine.
Exploring perceptions among people who drive after cannabis use: Collision risk, comparative optimism and normative influence
Authors: Wickens Christine M. , Watson Tara Marie , Mann Robert E. , Brands Bruna 
Published: March 2019

AbstractIntroduction and AimsWhile the perceived risks of driving under the influence of cannabis (DUIC) have been a focus of recent drug‐driving research, relevant concepts from the social cognition literature have rarely been applied to inform understanding of DUIC. This study aims to expand knowledge of perceived collision risk and social influences associated with DUIC and driving after other substance use.Design and MethodsSemi‐structured interviews were conducted with 20 participants of a remedial program for impaired drivers. Thematic analysis began with two independent coders. Early discussion of emergent themes resulted in the identification of applicable social cognition concepts, resulting in selective coding and interpretation.ResultsMany participants identified DUIC as less risky than driving under the influence of alcohol or other drugs. Mixed perceptions regarding the dangerousness of DUIC were expressed, with some participants denying increased collision risk except among novice cannabis users. Comparative optimism bias was also expressed by participants who perceived themselves as less likely than others to be involved in a collision when DUIC. In view of normative influence, friends were generally seen as more accepting of DUIC than family, and there were indications that the opinions of others who use cannabis were regarded as more credible than the opinions of those who do not use the drug.Discussion and ConclusionsComparative optimism bias and normative influence may contribute to perceived risks associated with DUIC and may, therefore, be useful concepts to employ to increase the effectiveness of public health and road safety initiatives.
Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes
Authors: Yan A. , Issar T. , Tummanapalli S. S. , Markoulli M. , Kwai N. C. G. , Poynten A. M. , Krishnan A. V. 
Published: March 2019

AbstractAimsTo investigate changes in corneal nerve morphology in Type 2 diabetes and to establish relationships between in vivo corneal confocal microscopy and markers of peripheral nerve structure and function.Participants and methodsWe recruited 57 participants with Type 2 diabetes and 26 healthy controls of similar age and sex distribution. We also recruited a disease control group of 54 participants with Type 1 diabetes. All participants were assessed for distal symmetrical polyneuropathy using the Total Neuropathy Score. In vivo corneal confocal microscopy was used to assess corneal nerve fibre length, corneal nerve fibre density, corneal nerve branch density and inferior whorl length. Peripheral nerve structure was assessed using median nerve ultrasonography. Large fibre function was assessed according to median nerve axonal excitability. Small fibre function was assessed using SudoscanTM and the Survey of Autonomic Symptoms.ResultsCorneal nerve fibre length, fibre density and branch density and inferior whorl length were significantly lower in individuals with Type 2 diabetes compared to controls (P<0.001 for all). In the Type 2 diabetes cohort, correlations were observed between neuropathy severity and corneal nerve fibre density (P=0.004), corneal nerve branch density (P=0.003), corneal nerve fibre length (P=0.002) and inferior whorl length (P=0.01). Significant correlations were observed between corneal confocal outcomes and axonal excitability measurements. No association was found between corneal confocal microscopy and median nerve cross‐sectional area, Sudoscan measurements or the Survey of Autonomic Symptoms.ConclusionsThis study demonstrated significant changes in corneal nerves in individuals with Type 2 diabetes. Reductions in corneal nerve measures correlated with increasing neuropathy severity. Associations were found between corneal confocal microscopy and markers of voltage‐gated potassium channel function.
Repeated payment delinquency among young adults in the United States
Authors: Letkiewicz Jodi C. , Heckman Stuart J. 
Published: March 2019

AbstractThere is concern in the United States about young adults falling behind financially due to the increased use of student loans and low wages. This study investigates payment delinquency as a measure of financial distress to better understand how young adults might be struggling. Personality traits are incorporated into the model to determine the extent to which behavioural factors are correlated with financial behaviors and if they predict a habit trend of payment delinquency. The 1997 National Longitudinal Survey of Youth, a nationally representative longitudinal data set, is used in the study. A random effects probit model and a dynamic random effects probit model are used to examine late bill pay (harassed by bill collectors) and late rent or mortgage payments (more than 60 days late) over a period of 8 years (2007–2015). Results from the analysis indicate that payment delinquency in a previous period increases the likelihood of payment delinquency by 10 percentage points in a subsequent period. Conscientiousness decreases the likelihood by 2.1 percentage points, while neuroticism increases the likelihood by 1.6 percentage points.
Examining the Global North Migration Policies: A “Push Out – Push Back” Approach to Forced Migration
Authors: Klaus Witold , Pachocka Marta 
Published: March 2019

AbstractIn this paper we focus on adapting the concept of push – pull factors to forced migration by proposing a “push out – push back” approach that underlines two most crucial elements of forced migrants’ experience. On the one hand, it stresses the reasons for leaving countries of origin or of temporary refuge that are not dependant on the will of people who flew those places, thus the “push out” factors. On the other hand, it represents the refusal of the countries of the Global North to accept forced migrants and their use of various practices, amounting to “push back” factors, to prevent them from entering or leaving their territory if they manage to reach it. These factors can be divided into three groups: passive, active, and symbolic.
Low positive predictive value of International Classification of Diseases, 10th Revision codes in relation to rheumatic heart disease: a challenge for global surveillance
Authors: Katzenellenbogen Judith M. , Nedkoff Lee , Cannon Jeffrey , Kruger Deborah , Pretty Filippa , Carapetis Jonathan R. , Dempsey Karen E. , De Dassel Jess , Anderson Mellise , de Klerk Nicholas , Hung Joseph 
Published: March 2019

AbstractInternational Classification of Diseases, 10th Revision codes for rheumatic heart disease (RHD) include valvular heart disease of unspecified origin, limiting their usefulness for estimating RHD burden. A cross‐disciplinary national consultation developed an algorithm to improve RHD identification in hospital data. The algorithm has been operationalised and piloted. The algorithm developed categorised 32% of RHD‐coded patients as probable/possible RHD. We outline a series of research initiatives to improve identification of RHD in administrative data thereby contributing to monitoring the RHD burden globally.
Why do not all living kidney donor candidates proceed to donation?
Authors: Cash Ellie , Graver Alison , Kuo Stephanie , Kirkland Geoffrey , Hughes Peter , Robertson Amanda , Jose Matthew D. 
Published: March 2019

AbstractThere are national and international guidelines for donor workup and acceptance criteria of potential living kidney donor candidates (LKDC), but there is significant variation in clinical practice. We examined our local practice in assessing potential LKDC against current guidelines; nearly all of our accepted donors met these guidelines. LKDC who did not proceed to donation had an identified health issue (60%), the presence of risk factors for long‐term end‐stage kidney disease (17%), social (13%) or immunological reasons (7%).
Ca2Na2La6(SiO4)4(PO4)2O: Eu2+/Eu3+: A visual dual‐emitting fluorescent ratiometric temperature sensor
Authors: Zhou Xufeng , Geng Wanying , Ding Jianyan , Zhao Zhengyan , Wang Yuhua 
Published: March 2019

AbstractA novel apatite‐based UV‐excited dual‐emitting Ca2Na2La6(SiO4)4(PO4)2O: Eu2+/Eu3+ phosphor (CNL: Eu2+/Eu3+) was designed and successfully synthesized by a solid‐state reaction. Compared with previous reports on this family of materials, a structural study based on DFT calculation exhibited a new consequence that the monovalent ions in this system are more inclined to occupy the seven‐coordinate cationic sites rather than the nine‐coordinate sites. This result was confirmed by the structural refinement and high‐resolution transmission electron microscopy (HRTEM) data. Due to the coexistence of Eu2+ and Eu3+ dopants in the material, under 345 or 392 nm excitation, CNL: 0.02Eu2+/Eu3+ exhibited a green Eu2+ emission band (528 nm) and red Eu3+ emission peaks (around 618 nm). The application potential of CNL:0.02Eu2+/Eu3+ in luminescent thermometry was studied by exploiting the temperature sensitivity of the fluorescent intensity ratio (green/red) at different temperatures. It was found that, under 345 nm excitation, the fluorescent intensity ratio of CNL: 0.02Eu2+/Eu3+ displayed linear correlation over the temperature range of 298 to 473 K with a high sensitivity of 2.82%K−1. Additionally, the emission color of the CNL: 0.02Eu2+/Eu3+ sample under UV lamp (254 and 365 nm) excitation showed an obvious change (from green to red) as the temperature increased from 298 to 473 K (from green to red). These results indicated that CNL: Eu2+/Eu3+ can serve as an excellent visual luminescent ratiometric thermometer. Furthermore, this work provides a novel reference for developing high‐performance luminescence temperature‐sensing materials.
Tunable colors and applications of Dy3+/Eu3+ co‐doped CaO‐B2O3‐SiO2 glasses
Authors: Zhou Wenli , Wang Guanhua , Zheng Xingxing , Yu Liping , Zhang Jilin , Qiu Zhongxian , Lian Shixun 
Published: March 2019

AbstractA series of Dy3+/Eu3+ single‐ and co‐doped calcium borosilicate luminescent glasses were prepared by the conventional high temperature melt‐quenching method. A compact glass structure is obtained by the addition of Dy3+/Eu3+ ions, which is verified by the physical properties of synthetic glasses. As network modifiers, Dy3+/Eu3+ fill in the interspaces of glass network and contribute to the conversion of [BO3] to [BO4]. Dy3+/Eu3+ co‐doped calcium borosilicate glasses can emit white light, which consists of blue, yellow, and red light under 387 nm excitation. The emission spectra and decay curves of the white‐emitting glasses have proved the existence of energy transfer. The average lifetime of Dy3+ decreases from 0.251 to 0.165 ms with the increasing Eu3+ concentration. Changing rare earth ions concentration, CIE color coordinates of Dy3+/Eu3+ co‐doped glass shifts from cyan to white with increasing excitation wavelength. A white‐light emission is obtained when the concentration of Dy3+ and Eu3+ equals to 4% and 2%, respectively. Moreover, the Dy3+/Eu3+ co‐doped calcium borosilicate glass shows high‐thermal stability and it may be applicable for high‐quality white LEDs based on high power near ultraviolet (n‐UV) LED chip in the future.
Mysm1 epigenetically regulates the immunomodulatory function of adipose‐derived stem cells in part by targeting miR‐150
Authors: Wang Yu‐Han , Huang Xiao‐Hui , Yang Yan‐Mei , He Youdi , Dong Xiao‐Hui , Yang Hui‐Xin , Zhang Lei , Wang Yan , Zhou Jin , Wang Changyong , Jiang Xiao‐Xia 
Published: March 2019

AbstractAdipose‐derived stem cells (ASCs) are highly attractive for cell‐based therapies in tissue repair and regeneration because they have multilineage differentiation capacity and are immunosuppressive. However, the detailed epigenetic mechanisms of their immunoregulatory capacity are not fully defined. In this study, we found that Mysm1 was induced in ASCs treated with inflammatory cytokines. Adipose‐derived stem cells with Mysm1 knockdown exhibited attenuated immunosuppressive capacity, evidenced by less inhibition of T cell proliferation, more pro‐inflammatory factor secretion and less nitric oxide (NO) production in vitro. Mysm1‐deficient ASCs exacerbated inflammatory bowel diseases but inhibited tumour growth in vivo. Mysm1‐deficient ASCs also showed depressed miR‐150 expression. When transduced with Mysm1 overexpression lentivirus, ASCs exhibited enhanced miR‐150 expression. Furthermore, Mysm1‐deficient cells transduced with lentivirus containing miR‐150 mimics produced less pro‐inflammatory factors and more NO. Our study reveals a new role of Mysm1 in regulating the immunomodulatory activities of ASCs by targeting miR‐150. These novel insights into the mechanisms through which ASCs regulate immune reactions may lead to better clinical utility of these cells.
Difference in the prevalence of gestational diabetes mellitus according to gestational age at 75‐g oral glucose tolerance test in Japan: The Japan Assessment of Gestational Diabetes Mellitus Screening trial
Authors: Iwama Noriyuki , Sugiyama Takashi , Metoki Hirohito , Kusaka Hideto , Yaegashi Nobuo , Sagawa Norimasa , Hiramatsu Yuji , Toyoda Nagayasu ,   The JAGS Group
Published: March 2019

AbstractAims/IntroductionTo evaluate the differences in the results of 75‐g oral glucose tolerance tests (OGTTs) according to gestational age in Japan.Materials and MethodsIn this prospective cohort study, 2,578 pregnant women were divided into three categories based on their gestational age during the 75‐g OGTT: <14 weeks’ gestation, 14–23 weeks’ gestation and 24–32 weeks’ gestation. The association between gestational age and the results of the 75‐g OGTT were evaluated using multivariable analysis.ResultsEarly gestational age was associated with high fasting plasma glucose levels at the time of the 75‐g OGTT, and low corresponding 1‐h and 2‐h plasma glucose levels. Compared with women with a gestational age of 24–32 weeks, women who had undergone the 75‐g OGTT at <14 weeks’ gestation had significantly higher odds of gestational diabetes mellitus diagnosis based on the currently used criteria in Japan (adjusted odds ratio 1.42, 95% confidence interval 1.07–1.90).ConclusionsThe results of the 75‐g OGTT varied by gestational age. The use of the same 75‐g OGTT cut‐off values for the diagnosis of gestational diabetes mellitus, regardless of gestational age, might lead to increases in the prevalence of gestational diabetes mellitus diagnosis in Japan.
The impact of airborne pollution on skin
Authors: Araviiskaia E. , Berardesca E. , Bieber T. , Gontijo G. , Sanchez Viera M. , Marrot L. , Chuberre B. , Dreno B. 
Published: March 2019

AbstractIndoor and outdoor airborne pollutants modify our environment and represent a growing threat to human health worldwide. Airborne pollution effects on respiratory and cardiac health and diseases have been well established, but its impact on skin remains poorly described. Nonetheless, the skin is one of the main targets of pollutants, which reach the superficial and deeper skin layers by transcutaneous and systemic routes. In this review, we report the outcomes of basic and clinical research studies monitoring pollutant levels in human tissues including the skin and hair. We present a current understanding of the biochemical and biophysical effects of pollutants on skin metabolism, inflammatory processes and oxidative stress, with a focus on polyaromatic hydrocarbons and ground‐level ozone that are widespread outdoor pollutants whose effects are mostly studied. We reviewed the literature to report the clinical effects of pollutants on skin health and skin ageing and their impact on some chronic inflammatory skin diseases. We also discuss the potential interactions of airborne pollutants with either ultraviolet radiation or human skin microbiota and their specific impact on skin health.
Risk factors of early rebleeding in the endoscopic management of colonic diverticular bleeding
Authors: Honda Hirokazu , Ishii Naoki , Takasu Ayaka , Shiratori Yasutoshi , Omata Fumio 
Published: March 2019

AbstractBackground and AimThe risk factors for early rebleeding following the management of colonic diverticular bleeding (CDB) are unclear. This study aimed to determine the risk factors for early rebleeding following initial colonoscopy.MethodsOverall, 370 patients with CDB were divided as having presumptive (229) or definite CDB with stigmata of recent hemorrhage (141) on the basis of initial colonoscopy. Definite CDB cases were treated by either endoscopic clipping (EC) or endoscopic band ligation (EBL) as a first‐line treatment. Time‐to‐event analysis for early rebleeding was performed by Kaplan–Meier methods with log‐rank test between the three groups (presumptive, EC, and EBL). Multivariate Cox proportional hazards regression was used to identify risk factors for early rebleeding.ResultsThere were 38 and 103 patients in the EC and EBL groups, respectively. Early rebleeding developed in 61 cases (16.5%). The cumulative incidence rates of early rebleeding at 1, 5, and 30 days were 7.7%, 16.4%, and 17.9% in the presumptive group; 1.9%, 7.0%, and 9.5% in the EBL group; and 2.6%, 34.9%, and 37.7% in the EC group, respectively (log‐rank test, P = 0.00059). Moreover, 90.2% of early rebleeding occurred within 5 days. Adjusted hazard ratio (HR) was marginally lower in the presumptive group (HR = 0.50; 95% confidence interval, 0.26–1.01; P = 0.052) and significantly lower in the EBL‐treated group than in the EC group (HR = 0.21; 95% confidence interval, 0.09–0.50; P = 0.0004).ConclusionsMost early rebleeding occurred within 5 days after initial colonoscopy. EC was less effective than EBL in terms of early rebleeding.