bluuebunny/crossref_metadata_2025_split huggingface dataset:
OSTEOGENIC SARCOMA IN FOUR SIBLINGS
Authors: Harmon T. P. , Morton K. S. 
Published: February 2018

1. The case histories of four siblings affected by osteogenic sarcoma are described. 2. The lesions appeared over a period of twelve years. The ages of the patients at the onset of symptoms were fifteen, twenty, eleven and twenty-two years. 3. The diagnosis of osteogenic sarcoma was in each case established by radiological and histological methods. 4. Two patients survived for eight and sixteen years after treatment and both are still alive and well.
THE EFFECTS OF HORMONES ON BONE IN GROWING RATS
Authors: Tapp E. 
Published: February 2018

1. In growing rats oestrogen, cortisone and thyroxine in high doses suppress bone formation, and this effect is probably part of a general suppression of body growth. 2. Growth hormone and thyroxine in small doses stimulate both body growth and bone formation. 3. Testosterone has no effect on bone formation. 4. Oestrogen and cortisone suppress bone resorption. The effect of cortisone may be modified in conditions of calcium depletion. 5. Thyroxine appears on the other hand to increase bone resorption. 6. Testosterone has no effect on bone resorption.
CHONDROSARCOMA OF BONE
Authors: Barnes R. , Catto Mary 
Published: February 2018

1. Chondrosarcoma is a malignant tumour of bone with clinical and morphological features which distinguish it from osteosarcoma. 2. Cartilage tumours present an unbroken spectrum in their clinical behaviour and histological appearances from the entirely benign to the frankly malignant. 3. A few chondrosarcomata, particularly those in children and young adults, run a rapidly fatal course but in general they metastasise late and some kill by local extension of the tumour. 4. "Secondary" chondrosarcomata arising from a pre-existing osteocartilaginous exostosis or enchondroma are mostly low grade tumours. 5. The first appearance of an osteocartilaginous exostosis after skeletal maturity, renewed growth, or pain unassociated with a fracture, should arouse suspicion of malignancy in any cartilage tumour. 6. Cartilage tumours of the trunk and upper end of femur and humerus are especially liable to sarcomatous change. 7. Although most benign cartilage tumours occur in the hand and foot they rarely become malignant with the exception of those in the calcaneus. 8. If biopsy is necessary it should be of the incisional type, a generous amount of material being removed from the edge of the tumour. Calcified, degenerate areas must be avoided. 9. In low grade tumours microscopic fields judged to be malignant by Lichtenstein and Jaffe's well established criteria may be scanty and many paraffin sections should be examined. Absence of mitotic figures, heavy calcification and poor vascularity are no guarantee of benignity. 10. Information as to the site of the tumour and age of the patient must be available to the pathologist if a useful report is to be given. 11 . In "borderline" tumours or where any difficulty in diagnosis arises the clinical, radiographic and histological features must all be taken into account and treatment based on the most unfavourable features. 12. Chondrosarcoma is a radio-resistant tumour and treatment is by radical excision or amputation. 13. Malignant cartilage cells implanted in the tissues at operation will often continue to grow and in all instances the biopsy wound and surrounding tissues must be removed en bloc with the tumour. 14. Small, low grade, readily accessible, peripheral tumours may be successfully treated by excision with a wide margin of healthy tissue. 15. In the limbs or pelvis large tumours and those of high grade malignancy should be treated by amputation. Since marrow permeation is often greater than the radiograph suggests amputation should, as a rule, not be performed through the bone in which the chondrosarcoma is situated. 16. Recurrence carries the danger that an initially accessible tumour becomes inaccessible and inoperable and, less frequently, a low grade tumour recurs in a metastasising form. 17. Recurrence is frequent after inadequate surgery; it indicates that the tumour is at least locally malignant and a cure can usually only then be achieved by more radical surgery.
POSTERIOR INTEROSSEOUS NERVE PARALYSIS CAUSED BY A GANGLION AT THE ELBOW
Authors: Bowen T. Llewellyn , Stone K. H. 
Published: February 2018

1. A case of posterior interosseous nerve palsy from compression in the supinator muscle by what appeared to be a simple ganglion is described. 2. Surgical decompression led to an effective cure. 3. The course of the nerve through this muscle invites compression. 4. Rotation of the forearm, especially with super-added deformity of the limb, may increase the compresssion.
FIBROGENESIS IMPERFECTA OSSIUM
Authors: Baker S. L. , Dent C. E. , Friedman M. , Watson Lyal 
Published: February 2018

1. A clinical, radiological and histological description of a patient with fibrogenesis imperfecta ossium is given. We think that this is the first case in which diagnosis has been made during the life of the patient. 2. The disease is characterised by a defect in the formation of the collagen fibres of the bone matrix. There is also a failure of normal calcification of the matrix, giving rise to the appearance of wide "osteoid" seams. When examined with the polarising microscope and when stained with Gomori's reticulin stain the collagen fibres can be seen to be grossly deficient and abnormal. 3. The patient presented at the age of fifty-four years with bone pain and multiple fractures. The only biochemical abnormality detected in the plasma was an elevated alkaline phosphatase. He was also in negative calcium balance. 4. Treatment with vitamin D2, later changed to dihydrotachysterol, appears to have produced clinical, biochemical and radiological improvement. It appears that a direct action of the vitamin on the abnormal bone collagen must be postulated, in addition to its known actions on the calcifying mechanisms. 5. An unusual feature of the case was the slow development of a total unresponsiveness to large doses of vitamin D2, in spite of a markedly elevated level of vitamin D in the plasma. There was later a response to a much smaller dose of dihydrotachysterol, which is being maintained to date.
NAIL-PATELLA SYNDROME WITH ILIAC HORNS AND HEREDITARY NEPHROPATHY
Authors: Darlington D. , Hawkins C. F. 
Published: February 2018

1 . Necropsy and dissection findings of a man of fifty-two who died from nail-patella syndrome are recorded. 2. The significance of the iliac horns are discussed and the literature concerning their development is reviewed. 3. Other anomalies are reviewed and the incidence of hereditary nephropathy is discussed. 4. The genetic origin ofthe syndrome is outlined but the involvement of such varying tissues remains unexplained.
LOWER CERVICAL RHEUMATOID SUBLUXATION WITH TETRAPLEGIA
Authors: Hopkins J. S. 
Published: February 2018

1. Four patients with tetraplegia from rheumatoid subluxation occurring in the lower cervical spine are described and the common features are noted. 2. Compression appeared to be responsible for the cord damage, although it was not necessarily directly related to vertebral subluxation. The lesions causing the compression were varied. 3. Forcible attempts to reduce vertebral subluxation may be harmful. Two patients were improved by posterior decompression. 4. A suggested programme for the treatment of such patients is outlined.
RESULTS OF TREATMENT OF 100 CONGENITALLY DISLOCATED HIPS
Authors: Somerville E. W. 
Published: February 2018

1. The results of the treatment of 100 congenitally dislocated hips out of 102 treated consecutively are reported. 2. The follow-up has been from five to fifteen years and the treatment of all has been the same. 3. The importance of adequate growth potential which determines the future development of the hip is stressed.
ISCHAEMIA COMPLICATING CLOSED TIBIAL AND FIBULAR SHAFT FRACTURES
Authors: Owen R. , Tsimboukis B. 
Published: February 2018

1. The frequency of variable degrees of ischaemia of soft tissue in closed tibial and fibular shaft fractures is emphasised. 2. Two cases with ischaemia of calf musculature are described. 3. A follow-up study of 100 cases of closed tibial shaft fractures is analysed; ten patients were found to be affected. 4. The anatomical and pathological changes are discussed. 5. A plea is made for early surgical exploration in cases manifesting signs of ischaemia.
OSTEOMALACIA–A COMMON DISEASE IN ELDERLY WOMEN
Authors: Chalmers J. , Conacher W. D. H. , Gardner D. L. , Scott P. J. 
Published: February 2018

1. The clinical features, diagnosis and treatment of osteomalacia are discussed in relation to thirty-seven recently recognised cases. It is suggested that this disease is not uncommon in elderly women, among whom it is liable to be confused with senile osteoporosis. Osteomalacia may be distinguished by, firstly, the history, in which persistent skeletal pain of long duration and muscular weakness are typical of osteomalacia, but not of osteoporosis in which transient episodes of pain usually associated with a fracture are more characteristic. There is a high incidence of previous gastric surgery in the osteomalacia patients. Secondly, the physical examination shows skeletal tenderness in osteomalacia but this is not a particular feature of osteoporosis. A shuffling "penguin gait" suggests osteomalacia. Thirdly, the biochemistry shows a low plasma calcium and phosphate, and raised alkaline phosphatase levels commonly in osteomalacia but these are usually normal in osteoporosis. Reduced twenty-four-hour urinary calcium is characteristic of osteomalacia but not of osteoporosis. Fourthly, radiology will show diminished bone density which is common to both diseases, but if the changes are more marked in the peripheral bones than in the axial skeleton osteomalacia is suggested; the opposite is typical of osteoporosis. Skeletal deformity without fracture suggests osteomalacia, as do stress fractures and greenstick fractures in the elderly. Looser's zones are diagnostic of osteomalacia in which they are the most important radiological feature. Finally, histology will show the presence of excess osteoid tissue in undecalcified sections of bone in osteomalacia. This may be the earliest and most sensitive index of the disease and biopsy is indicated in all doubtful cases. 2. The etiology is discussed and it is suggested that a dietary deficiency of vitamin D, limited exposure to sunlight and mild degrees of malabsorption may all be important either alone or in combination. No satisfactory explanation is offered for the predominant female incidence. 3. A practical method of treatment is given and the dangers of uncontrolled administration of vitamin D indicated. 4. Treatment of osteomalacia is rapidly and consistently successful, and well justifies a thorough screening of all elderly patients presenting with weakness, skeletal pain, pathological fractures or with diminished radiographic density of bone.
UNION OF INTERTROCHANTERIC OSTEOTOMIES
Authors: Green J. P. 
Published: February 2018

1. Fibrous union of an osteotomy occurred in only 3 per cent of osteotomies done during a four-year period. 2. Delayed union sometimes gives rise to pain on bearing weight while union is in progress, and non-union is usually associated with disabling pain. 3. The most significant factors predisposing to delayed or fibrous union are inefficient fixation and excessive displacement. A high or very oblique osteotomy may also have an adverse effect upon the rate of bony union.
FAMILIAL SLIPPED UPPER FEMORAL EPIPHYSIS
Authors: Rinnie A. M. 
Published: February 2018

1. During the past twenty-five years there have been admitted to this orthopaedic service twelve children or adolescents having a close relative who previously or subsequently developed slipped upper femoral epiphysis. This represents an incidence of approximately 7 per cent. 2. There is some evidence that the incidence is considerably higher. 3. In addition to those with close relations also with slipped epiphysis, two patients had parents with osteoarthritis of the hip. 4. I believe, therefore, that in slipped upper femoral epiphysis there is evidence of a genetic defect. This is probably due to a recessive gene of low penetrance. The frequency in this region is high because the north-east of Scotland has very definite geographical boundaries and the rural, agricultural population, from which the majority of these cases were drawn, has formed until recently a stable community likely to show a greater than average incidence.
OSTEOPOROSIS AND FRACTURE OF THE FEMORAL NECK IN THE SOUTH AFRICAN BANTU
Authors: Solomon L. 
Published: February 2018

1. Senile osteoporosis is one of the common causes of morbidity in old people. Its distribution in European and American populations has been deduced from epidemiological studies of its major complications, such as fractures of the vertebrae and the femoral neck. Although there has been some evidence that different population groups differ in their susceptibility to this condition, no demographic study of its prevalence in the white and Bantu races has previously been made. 2. The present paper describes an epidemiological study of femoral neck fractures in the Bantu population of Johannesburg, covering the years 1957-63. The cases were analysed by age and sex, the type of trauma and the level of the fracture. The number of fractures was related to the population at risk; the fracture incidence was expressed both as an age-specific rate and as a standardised rate and compared with fracture rates in European populations. It was found that the fracture rate in the elderly Bantu is less than one-tenth of that in Western European populations, and that males and females are affected equally. It was concluded that senile or post-menopausal osteoporosis is much less pronounced in the Bantu than in white populations. 3. The relationship of these findings to endocrine changes, calcium balance and racial factors is discussed. It is suggested that senile osteoporosis is not caused by a simple calcium deficiency but may be related to an imbalance between calcium intake, absorption and excretion, or a failure of the complex mechanism which normally controls this balance. Whatever the immediate cause, however, race plays an important part in determining the onset and distribution of the condition.
FAMILIAL (IDIOPATHIC) SCOLIOSIS
Authors: Wynne-Davies Ruth 
Published: February 2018

1. Idiopathic scoliosis is a familial condition. 2. The findings suggest either dominant or multiple gene inheritance, but a larger series is needed before a firm conclusion can be drawn. 3. The infantile and adolescent types of scoliosis seem to share the same basic etiology, because their families contain instances of each. 4. Infants with resolving scoliosis have affected relatives in the same proportions as in the main group, suggesting this is a mild form of the same disorder. 5. In this series all infants seen with scoliosis under one year of age had plagiocephaly, which was usually transient. 6. Mental defect and epilepsy are the commonest findings associated with scoliosis. 7. In adolescent scoliosis the age of the mother is significantly raised by comparison with the expected figure for the normal population.
ABNORMAL ARRANGEMENT OF THE LOWER LUMBAR AND FIRST SACRAL NERVES WITHIN THE SPINAL CANAL
Authors: Keon-Cohen Bryan 
Published: February 2018

1. Four cases of abnormal arrangement of the lower lumbar and sacral nerves within the spinal canal are reported. 2. In all four cases the presentation was like that associated with acute lumbar disc protrusion, though in only two cases was a protrusion found at operation. 3. The significance of the findings is discussed and the findings are compared with those in the eighteen other recorded cases.
QUADRICEPS CONTRACTURE
Authors: Williams Peter F. 
Published: February 2018

1. Previous reports of the role of the quadriceps in producing limitation of movement or dislocation of the patella have tended to implicate one particular part of the complex. Experience gained in thirty-five quadricepsplasties in children has shown that all parts of the quadriceps (except vastus medialis) and the ilio-tibial band also may play a part and that each of these must be attended to if a satisfactory result is to be obtained. 2. A simple technique of operation is described and illustrated. 3. Since this paper was prepared, a patient showing features of particular interest has been seen and treated.
PRIMARY OSTEOARTHRITIS, VENOUSIENGORGEMENT AND OSTEOGENESIS
Authors: Brookes M. , Helal B. 
Published: February 2018

1. The venographic findings in clinical primary osteoarthritis are described. 2. Experimental venous engorgement, of the knee joint and of healing fibular fractures, results in accelerated bone formation and disturbed cartilage formation. 3. Changes in pH, ppCO2, and PPO2 are indicated as the chemical means by which chondrogenesis and osteogenesis can be altered. 4. It is suggested that chronic venous stress in joints is a causal factor in primary osteoarthritis.
CLINICAL EXAMINATION AND URINARY OESTROGEN ASSAYS IN NEWBORN CHILDREN WITH CONGENITAL DISLOCATION OF THE HIP
Authors: Thieme W. T. , Wynne-Davies Ruth , Blair H. A. F. , Bell E. T. , Loraine J. A. 
Published: February 2018

1. Twenty-one cases of congenital dislocation of the hip were found on examination of 1,881 consecutive neonates on the first day of life, giving an incidence of eleven per 1,000 live births. 2. Insignificant high-pitched "clicks" were noted in 10 per cent of newborn children. 3. Conversion of half of the patients with hip dislocation to normal occurred during the first post-natal week. 4. Joint laxity was not a feature of the newborn with congenital dislocation of the hip. 5. Oestradiol, oestrone and oestriol were estimated in twenty-fourhour urine samples collected from sixteen patients with congenital dislocation of the hip and nineteen matched controls during the first six days of life. No significant differences in oestrogen output between the two groups were found. 6. The hypothesis that congenital dislocation of the hip is a result of an inborn error of oestrogen metabolism in the newborn is not supported.
DEVELOPMENT OF A SURGICALLY IMPLANTED MYO-TELEMETRY CONTROL SYSTEM
Authors: Tucker F. R. , Scott R. N. 
Published: February 2018

1. The difficulties of obtaining myo-electric signals from the muscles in amputation stumps are discussed. 2. The requirements of a myo-telemetry system which could be implanted are discussed. 3. A description is given of a new approach to the problem in which the electrical unit is contained in an inert plastic and fitted into the bone in the amputation stump, using an external power source.
THE LONG-TERM REACTION OF BONE TO SELF-CURING ACRYLIC CEMENT
Authors: Charnley J. , Follacci F. M. , Hammond B. T. 
Published: February 2018

1. A study is reported of 190 femora in 174 patients in whom self-curing acrylic cement had been present in the medullary cavity of the upper end of the femur for the fixation of an endoprosthesis for an average period of four years. 2. The bone remained radiologically normal in 81 per cent of cases. 3. Improvement in the thickness of the cortex from pre-existing atrophy was noted in 2·6 per cent. 4. In 4·7 per cent the bone showed some atrophy after insertion of the cement. This exceeded 10 per cent in only two cases. All were originally osteoporotic from polyarthritis; all were satisfactory as regards the arthroplasty itself, and the atrophy could usually be explained by disuse resulting from the state of the opposite lower extremity, or the knee on the same side. 5. In 9·4 per cent there was fusiform hypertrophy of the femoral cortex, the bony texture remaining normal. This appearance was considered physiological and benign. 6. In 2·2 per cent there were changes for which the most likely explanation is chronic non-suppurative osteitis, though no collateral evidence of infection was found. 7. In 44·8 per cent there was a thin line of condensation in the cancellous bone demarcating the outer limits of the cement. This is considered to be physiological and not to indicate failure of immobilisation. 8. In 37·2 per cent there was slight resorption of the cut surface of the calcar femorale. This is considered to be physiological and to confirm the efficacy of weight transmission by cement lower down in the medullary cavity.
THE ANATOMY OF UNCORRECTED CLUB FEET
Authors: Swann Malcolm , Lloyd-Roberts G. C. , Catterall A. 
Published: February 2018

1. We have considered torsional deformity in club feet and conclude that medial torsion does not occur in the tibia. 2. It is suggested that in uncorrected feet the hindfoot with the ankle mortise is laterally rotated. 3. We have discussed the cause, prevention and consequences of spurious correction by lateral rotation. 4. The "bean-shaped foot" seems an appropriate description of the final deformity as it is commonly seen.
THE GROWTH OF BONE AUTOGRAFTS IN RABBIT EAR CHAMBERS
Authors: Ezra-Cohn H. E. , Bullough Peter G. , Trueta J. 
Published: February 2018

1. A method is described for the in vivo and in vitro study of osteogenesis by implanting a modified transparent chamber in half lop-eared rabbits (as originated by Sandison 1928). This method allows the daily observation and photography of the developing bone and the study of its intimate connection with the vascularity of the area. 2. The osteogenetic potential of a variety of substances can also be investigated by this method. The tissue in the chamber can easily be prepared for its final examination by optical and electron microscopy and by other laboratory techniques.
COMPRESSION OF THE DEEP PALMAR BRANCH OF THE ULNAR NERVE
Authors: Hayes J. R. , Mulholland R. C. , O'Connor B. T. 
Published: February 2018

1. A case of compression of the deep branch of the ulnar nerve is described. 2. Anatomical evidence is presented that the reason for the special liability of the deep branch to be compressed by ganglia in this region is its relationship to a ligamentous band which passes from the pisiform bone to the hamate superficial to the deep branch of the ulnar nerve. 3. This band, though constant, has not been well recognised.
A REVIEW OF LONG-TERM RESULTS OF ARTHRODESIS OF THE FIRST METATARSO-PHALANGEAL JOINT
Authors: Fitzgerald J. A. W. 
Published: February 2018

1. One hundred cases of arthrodesis of first metatarso-phalangeal joint have been reviewed after a post-operative interval of at least ten years. 2. Seventy-seven per cent of patients were completely satisfied with the late results ; only 9 per cent were dissatisfied. 3. The two major factors leading to poor results were found to be malposition of the arthrodesis, and interphalangeal osteoarthritis. 4. The ideal position for fusion is considered to be in at least 20 degrees of valgus, preferably between 20 and 30 degrees ; between 20 and 40 degrees of dorsiflexion ; and most importantly, neutral rotation. 5. The precise operative technique is not important provided it maintains the position obtained at operation until the arthrodesis is sound.