bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common and unique effects of HD-tDCS to the social brain across cultural groups
Authors: Martin A. K. , Su P. , Meinzer M. 
Published: September 2018

ABSTRACTCultural background influences social cognition, however no study has examined brain stimulation differences attributable to cultural background. 104 young adults [52 South-East Asian Singaporeans (SEA); 52 Caucasian Australians (CA)] received anodal high-definition transcranial direct current stimulation (HD-tDCS) to the dorsomedial prefrontal cortex (dmPFC) or the right temporoparietal junction (rTPJ). Participants completed tasks with varying demands on self-other processing including visual perspective taking and episodic memory with self and other encoding. At baseline, SEA showed greater self-other integration than CA in the level one (line-of-sight) VPT task as indexed by greater interference from the alternate perspective. Anodal HD-tDCS to the dmPFC resulted in the CA performing closer to the SEA during egocentric perspective judgements. Baseline performance on level two (embodied rotation) VPT task and the self-reference effect in memory (SRE) was comparable between the two groups. In the combined sample, HD-tDCS to the rTPJ decreased the interference from the egocentric perspective during level two VPT and dmPFC HD-tDCS removed the SRE in episodic memory. Stimulation effects were comparable when baseline performance was comparable. When baseline performance differed, stimulation differences were identified. Therefore, social cognitive differences due to cultural background are an important consideration in social brain stimulation studies.HIGHLIGHTSCompared with Caucasians, South-East Asians were influenced by the alternate perspective to a greater extent during level one visual perspective takingAnodal HD-tDCS to the dmPFC shifted Caucasians closer to the baseline performance of South-East AsiansAnodal HD-tDCS to the dmPFC removed the self-reference effect in episodic memory in both cultural groupsAnodal HD-tDCS to the dmPFC reduced overall memory performance in the South-East Asians but not in the Caucasian groupAnodal HD-tDCS to the rTPJ reduced egocentric interference in a level two visual perspective taking task in both cultural groups
Live-Cell Imaging Reveals Enhancer-dependent Sox2 Transcription in the Absence of Enhancer Proximity
Authors: Alexander Jeffrey M. , Guan Juan , Huang Bo , Lomvardas Stavros , Weiner Orion D. 
Published: September 2018

ABSTRACTEnhancers are important regulatory elements that can control gene activity across vast genetic distances. However, the underlying nature of this regulation remains obscured because it has been difficult to observe in living cells. Here, we visualize the spatial organization and transcriptional output of the key pluripotency regulatorSox2and its essential enhancerSox2Control Region (SCR) in living embryonic stem cells (ESCs). We find thatSox2and SCR show no evidence of enhanced spatial proximity and that spatial dynamics of this pair is limited over tens of minutes.Sox2transcription occurs in short, intermittent bursts in ESCs and, intriguingly, we find this activity demonstrates no association with enhancer proximity, suggesting that direct enhancer-promoter contacts do not drive contemporaneousSox2transcription. Our study establishes a framework for interrogation of enhancer function in living cells and supports an unexpected mechanism for enhancer control ofSox2expression that uncouples transcription from enhancer proximity.
Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy
Authors: Jones Emily J , Matthews Zoe J , Gul Lejla , Sudhakar Padhmanand , Treveil Agatha , Divekar Devina , Buck Jasmine , Wrzesinski Tomasz , Jefferson Matthew , Armstrong Stuart D , Hall Lindsay J , Watson Alastair JM , Carding Simon R , Haerty Wilfried , Di Palma Federica , Mayer Ulrike , Powell Penny P , Hautefort Isabelle , Wileman Tom , Korcsmaros Tamas 
Published: September 2018

Summary statementUsing an integrative approach encompassing intestinal organoid culture, proteomics, transcriptomics and protein-protein interaction networks, we list Paneth cell functions dependent on autophagy.AbstractPaneth cells are key epithelial cells providing an antimicrobial barrier and maintaining integrity of the small intestinal stem cell niche. Paneth cell abnormalities are unfortunately detrimental to gut health and often associated with digestive pathologies such as Crohn’s disease or infections. Similar alterations are observed in individuals with impaired autophagy, a process which recycles cellular components. The direct effect of autophagy-impairment on Paneth cells has not been analysed. To investigate this, we generated a mouse model lacking Atg16l1 specifically in intestinal epithelial cells making these cells impaired in autophagy. Using 3D intestinal organoids enriched for Paneth cells, we compared the proteomic profiles of wild-type (WT) and autophagy-impaired organoids. We used an integrated computational approach combining protein-protein interaction networks, autophagy targeted proteins and functional information to identify the mechanistic link between autophagy-impairment and disrupted pathways. Of the 284 altered proteins, 198 (70%) were more abundant in autophagy-impaired organoids, suggesting reduced protein degradation. Interestingly, these differentially abundant proteins comprised 116 proteins (41%), predicted targets of the selective autophagy proteins p62, LC3 and ATG16L1. Our integrative analysis revealed autophagy-mediated mechanisms degrading proteins key to Paneth cell functions, such as exocytosis, apoptosis and DNA damage repair. Transcriptomic profiling of additional organoids confirmed that 90% of the observed changes upon autophagy alteration affect protein level and not gene expression. We performed further validation experiments showing differential lysozyme secretion, confirming our computationally inferred down-regulation of exocytosis. Our observations could explain how protein level alterations affect Paneth cell homeostatic functions upon autophagy impairment.
Hybrid realization of fillet weld
Authors: Kotlan Václav , Hamar Roman , Šroubová Lenka , Doležel Ivo 
Published: September 2018

Purpose
A model of hybrid fillet welding is built and solved. No additional material (welding rod, etc.) is used. Heating of the welded parts is realized by laser beam with induction preheating and/or postheating. The purpose of these operations is to reduce the temperature gradient in welded parts in the course of both heating and cooling, which reduces the resultant hardness of the weld and its neighborhood and also reduces undesirable internal mechanical strains and stresses in material.

Design/methodology/approach
The complete mathematical model of the combined welding process is presented, taking into account all relevant nonlinearities. The model is then solved numerically by the finite element method. The methodology is illustrated with an example, the results of which are compared with experiment.

Findings
The proposed model provided satisfactory results even when some subtle phenomena were not taken into account (flow of melt in the pool after irradiation of the laser beam driven by the buoyancy and gravitational forces and evaporation of molten metal and influence of plasma cloud above the irradiated spot).

Research limitations/implications
Accuracy of the results depends on the accuracy of physical parameters of materials entering the model and their temperature dependencies. These quantities are functions of chemical composition of the materials used, and may more or less differ from the values delivered by manufacturers. Also, the above subtle physical phenomena exhibit stochastic character and their modeling may be accompanied by non-negligible uncertainties.

Practical implications
The presented model and methodology of its solution may represent a basis for design of welding processes in various branches of industry.

Originality/value
The model of a complex multiphysics problem (induction-assisted laser welding) provides reasonable results confirmed by experiments.
Composite beam identification using a variant of the inhomogeneous wave correlation method in presence of uncertainties
Authors: Lajili Ramzi , Bareille Olivier , Bouazizi Mohamed Lamjed , Ichchou Mohamed , Bouhaddi Noureddine 
Published: September 2018

Purpose
This paper aims to propose numerical-based and experiment-based identification processes, accounting for uncertainties to identify structural parameters, in a wave propagation framework.

Design/methodology/approach
A variant of the inhomogeneous wave correlation (IWC) method is proposed. It consists on identifying the propagation parameters, such as the wavenumber and the wave attenuation, from the frequency response functions. The latters can be computed numerically or experimentally. The identification process is thus called numerical-based or experiment-based, respectively. The proposed variant of the IWC method is then combined with the Latin hypercube sampling method for uncertainty propagation. Stochastic processes are consequently proposed allowing more realistic identification.

Findings
The proposed variant of the IWC method permits to identify accurately the propagation parameters of isotropic and composite beams, whatever the type of the identification process in which it is included: numerical-based or experiment-based. Its efficiency is proved with respect to an analytical model and the Mc Daniel method, considered as reference. The application of the stochastic identification processes shows good agreement between simulation and experiment-based results and that all identified parameters are affected by uncertainties, except damping.

Originality/value
The proposed variant of the IWC method is an accurate alternative for structural identification on wide frequency ranges. Numerical-based identification process can reduce experiments’ cost without significant loss of accuracy. Statistical investigations of the randomness of identified parameters illustrate the robustness of identification against uncertainties.
Creating the mobile engineer: a study of a training program for engineering consultants
Authors: Pantic-Dragisic Svjetlana , Borg Elisabeth 
Published: September 2018

Purpose
The purpose of this paper is to explore how a technical consulting firm approaches the development of engineering consultants, to prepare them to deal with their liminal, i.e. mobile and transient work situation. More specifically, this paper addresses how a training program, designed for newly graduated engineers, can increase the consultants’ liminality competence.

Design/methodology/approach
This paper reports on a qualitative case study of an introductory development program in a Scandinavian technical consulting firm. The study is based on observations of training sessions and meetings, and interviews with developers, leaders and participants of the program.

Findings
This study identifies three processes, which develop the engineering consultants’ ability to master their mobile and transient work situation: identifying the core of an assignment, embracing “in-betweenness” and broadening the scope of action.

Originality/value
This paper enhances the understanding of formal training in the context of technical consulting and adds to the knowledge of how engineering consultants can master their liminal work positions; in particular, the study identifies how liminality competence can be elevated through formal training.
The influence of personal- and business centre characteristics on knowledge sharing types in business centres
Authors: Weijs-Perrée Minou , Appel-Meulenbroek Rianne , Arentze Theo , Romme Georges 
Published: September 2018

PurposeKnowledge sharing is a process where individuals mutually exchange knowledge to create new knowledge. Understanding the knowledge-sharing process, during which organizations share spaces, facilities and services, is highly important for owners/managers who seek to optimize their business centres and to attract more innovative tenants. For users of business centres, it is interesting to know how, where and what type of knowledge is shared. However, there is hardly any research into sharing different types of knowledge in business centres. The purpose of this paper is to analyse the influence of personal and organizational characteristics on sharing different types of knowledge within and between organizations in business centres.Design/methodology/approachData were collected using a questionnaire that was completed by 268 users of 53 business centres in The Netherlands. A seemingly unrelated regression analysis was used to simultaneously analyse the influence of personal and organizational characteristics on knowledge sharing in business centres.FindingsThe results show that public and private non-codified knowledge is more frequently shared with people from other organizations by those who more frequently use an event space, lounge space, canteen or consultancy services. Knowledge sharing with colleagues within organizations was influenced by the use of individual closed workspaces, meeting spaces and restaurant/canteen and gender.Originality/valueThe study suggests that owners and managers of business centres can optimize their business centres by offering specific facilities, services and workspaces to attract a specific group of tenants. In addition, organizations that want to enhance knowledge sharing with other organizations need to stimulate their employees to use shared facilities and services.
Risks, coping strategies and family wellbeing: evidence from Finland
Authors: Lindberg Marja , Nygård Mikael , Nyqvist Fredrica 
Published: September 2018

PurposeAs a member of the Nordic welfare regime, Finland has been acknowledged for its encompassing family policies with high degrees of parental employment and low incidence of poverty. During recent years, however, sluggish growth, high levels of unemployment and recurrent austerity measures have gradually undermined the economic security of families, notably among single-parent and multi-child families, and this has put families under increasing strain and increased the risks of poverty, inequality and other forms of ill-being. The paper aims to discuss these issues.Design/methodology/approachIn this paper, the authors investigate risks and coping strategies and well-being of Finnish families with children. Family well-being is defined as an umbrella concept covering economic, social or psychological well-being and physical health. The data consist of 22 qualitative semi-structured interviews with parents from the region of Ostrobothnia in Finland and were collected in the winter of 2016–2017.FindingsBased on the findings, the authors argue that the risks the families in Finland confront are linked to lower well-being, most notably for families encountering sickness, unemployment or divorce. The findings also show that parents have to employ various coping strategies themselves and that the society’s support is insufficient.Originality/valueThis paper, thus, contributes to the literature on the effects of austerity policies on families by focussing on the consequences on family well-being, but also on the risks that families face and the coping mechanisms they use for handling with these risks.
Family or state responsibility? Elderly- and childcare policy preferences in Spain
Authors: Valarino Isabel , Meil Gerardo , Rogero-García Jesús 
Published: September 2018

PurposeSpain is typically considered a familialistic country where the family is the main responsible for individuals’ well-being. Recent demographic, socioeconomic and policy changes raise the question to what extent familialism is regarded as the preferred care arrangement in society or whether more state support is considered legitimate. The purpose of this paper is to analyse individual preferences among Spanish residents regarding care responsibility for pre-school children and the frail elderly, and the factors that influence such preferences.Design/methodology/approachRepresentative data from the 2012 International Social Survey Programme are used (n=1419). Six patterns of care responsibility that capture preferences regarding who, between the family or the state, should provide and pay for the care of pre-school children and the frail elderly are identified. Logistic regressions are performed on each care responsibility pattern to analyse the factors influencing individuals’ preferences.FindingsMultiple preferences coexist and state responsibility is often preferred over family responsibility, especially for elderly-care. It suggests that the tendency to rely on the family in Spain is due to insufficient support rather than to familialistic values. Individuals who usually bear most care work responsibilities, such as women and individuals in caring ages, or those with a poor health, high care load or low income consider there should be extra-family support. Individuals’ values also matter: the least religious, the most supportive of maternal employment and left-wing voters are most likely to reject traditional care arrangements.Originality/valueThis is the first study to analyse both elderly- and childcare policy preferences in one single study. It shows that childcare is more often seen as a family responsibility than elderly care.
Multi-class Twitter sentiment classification with emojis
Authors: Li Mengdi , Ch’ng Eugene , Chong Alain Yee Loong , See Simon 
Published: September 2018

Purpose
Recently, various Twitter Sentiment Analysis (TSA) techniques have been developed, but little has paid attention to the microblogging feature – emojis, and few works have been conducted on the multi-class sentiment analysis of tweets. The purpose of this paper is to consider the popularity of emojis on Twitter and investigate the feasibility of an emoji training heuristic for multi-class sentiment classification of tweets. Tweets from the “2016 Orlando nightclub shooting” were used as a source of study. Besides, this study also aims to demonstrate how mapping can contribute to interpreting sentiments.

Design/methodology/approach
The authors presented a methodological framework to collect, pre-process, analyse and map public Twitter postings related to the shooting. The authors designed and implemented an emoji training heuristic, which automatically prepares the training data set, a feature needed in Big Data research. The authors improved upon the previous framework by advancing the pre-processing techniques, enhancing feature engineering and optimising the classification models. The authors constructed the sentiment model with a logistic regression classifier and selected features. Finally, the authors presented how to visualise citizen sentiments on maps dynamically using Mapbox.

Findings
The sentiment model constructed with the automatically annotated training sets using an emoji approach and selected features performs well in classifying tweets into five different sentiment classes, with a macro-averaged F-measure of 0.635, a macro-averaged accuracy of 0.689 and the MAEM of 0.530. Compared to those experimental results in related works, the results are satisfactory, indicating the model is effective and the proposed emoji training heuristic is useful and feasible in multi-class TSA. The maps authors created, provide a much easier-to-understand visual representation of the data, and make it more efficient to monitor citizen sentiments and distributions.

Originality/value
This work appears to be the first to conduct multi-class sentiment classification on Twitter with automatic annotation of training sets using emojis. Little attention has been paid to applying TSA to monitor the public’s attitudes towards terror attacks and country’s gun policies, the authors consider this work to be a pioneering work. Besides, the authors have introduced a new data set of 2016 Orlando Shooting tweets, which will be made available for other researchers to mine the public’s political opinions about gun policies.
The impact of branding strategies on horizontal and downward line extension of luxury brands
Authors: Boisvert Jean , Ashill Nicholas J. 
Published: September 2018

Purpose
The purpose of this paper is to empirically assess the impact of branding strategies on horizontal and downward line extensions of French luxury brands in a cross-national context (France vs USA).

Design/methodology/approach
This study is based on a two line extensions (horizontal/downward) × three branding strategies (direct brand/sub-brand/standalone brand) x two country (France/USA) between-subjects ANOVA design.

Findings
The study shows that the subtyping effect created by a sub-branded luxury downward line extension tends to be rated similarly to a direct branded extension which oppose previous beliefs put forward in non-luxury settings. In contrast, a new independent/standalone extension fully uses the subtyping effect which helps attenuate this risk related to luxury downward stretches. The study also found that the effect of gender in cross-national settings must always be taken into consideration as significant variations occur in the process.

Research limitations/implications
The study covers two countries but should be replicated in other cross-national contexts.

Practical implications
This study helps marketing managers of luxury brands make a better decision when it comes to launching vertical line extensions (upscale/downward) by carefully using types of branding strategies and relevant communications whether women and/or men are targeted in cross-national contexts.

Originality/value
This study breaks new ground in the international luxury literature by providing key theoretical and managerial insights in terms of launching new downward line extensions with the proper use of branding strategies when targeting specific genders.
Social media environments effect on perceived interactivity
Authors: Xu Xi , Yao Zhong , Sun Qing 
Published: September 2018

Purpose
The purpose of this paper is to treat WeChat moments as social media environments and applies the research model to explore the effect of social media environments on perceived interactivity from the perspective of environmental psychology.

Design/methodology/approach
This paper proposes social media environments as effective stimuli for future participate in online social interactions. First, two cues of social media environments (user-to-system cues and user-to-user cues) can be important antecedents of users’ perception of interactivity. Second, users’ intention of future participates in online social interactions can be influenced by three dimensions of perceived interactivity (action control, connectedness and responsiveness). Using data from 334 users of WeChat moments, the authors conduct partial least squares analysis to validate the research model.

Findings
The results indicate that both technological and social environments positively affect three dimensions of perceived interactivity, respectively, including action control, connectedness and responsiveness. Moreover, actual findings also suggest that higher perceived interactivity increases users’ intention of future participate in online social interactions.

Originality/value
This work contributes to in-depth research on the relationships between social environments and perceived interactivity. Besides, this paper demonstrates that both technological and social cues of social media environments are significant elements in simulating users’ internal experience and behavioral intention. The main conclusions of this study can be valuable to social media developers and managers.