bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complement C3a promotes proliferation, migration and stemness in cutaneous squamous cell carcinoma
Authors: Fan Zhuo , Qin Jingjing , Wang Dandan , Geng Songmei 
Published: March 2019

AbstractBackgroundComplement C3 has been shown to be highly expressed in cutaneous squamous cell carcinoma (cSCC) tumour tissues and is correlated with tumour cell growth. This study aimed to investigate the mechanism of C3 in cSCC malignant transformation.MethodsC3 expression was analysed in cSCC cell lines A431, Tca8113, SCC13, HSC‐5 and HSC‐1 and in immortalized HaCaT keratinocytes. Proliferation and migration of cSCC were determined after C3a exposure. Expression of cyclin D1, cyclin E, vascular endothelial growth factor (VEGF), pro‐matrix metalloproteinase 1 (pro‐MMP1), pro‐matrix metalloproteinase 2 (pro‐MMP2), stemness factors, GSK‐3β, and β‐catenin were analyzed. Tumour growth was examined in a murine xenograft model.ResultsC3 expression was much more highly expressed in all cSCC cell lines than in HaCaT cells. C3a treatment significantly promoted cSCC cell proliferation and migration and upregulated cyclin D1, cyclin E, VEGF, pro‐MMP1 and pro‐MMP2 expression, which were impeded by the C3aR antagonist. Moreover, the expression of stemness factors Sox‐2, Nanog, Oct‐4, c‐Myc and CD‐44 was stimulated by C3a and slowed by C3aR disruption. Knockdown of Sox‐2 by siRNA transfection suppressed cell proliferation and migration, constrained VEGF secretion and inhibited pro‐MMP1 and pro‐MMP2 expression. C3a also activated the Wnt and β‐catenin pathway in cSCC cells. Disruption of C3aR expression dampened tumour growth and the expression of Wnt‐1, β‐catenin and Sox‐2 in the xenograft model.ConclusionsC3a enhanced cell proliferation, migration and stemness in cSCC, and this activity was correlated with activation of the Wnt and β‐catenin pathway.
Long non‐coding RNA ZEB2‐AS1 promotes the proliferation, metastasis and epithelial mesenchymal transition in triple‐negative breast cancer by epigenetically activating ZEB2
Authors: Zhang Guoxin , Li Hongli , Sun Ruimei , Li Peirui , Yang Zhiyi , Liu Yuanyuan , Wang Zhaoyan , Yang Yuling , Yin Chonggao 
Published: March 2019

AbstractThe triple‐negative breast cancer is the most malignant type of breast cancer. Its pathogenesis and prognosis remain poor despite the significant advances in breast cancer diagnosis and therapy. Meanwhile, long noncoding RNAs (LncRNAs) play a pivotal role in the progression of malignant tumors. In this study, we found that LncRNA‐ZEB2‐AS1 was dramatically up‐regulated in our breast cancer specimens and cells (MDA231), especially in metastatic tumor specimens and highly invasive cells, and high lncRNA‐ZEB2‐AS1 expression is associated with clinicopathologic features and short survival of breast cancer patients. LncRNA‐ZEB2‐AS1 promotes the proliferation and metastasis of MDA231 cells in SCID mice. Thus, it is regarded as an oncogene in triple‐negative breast cancer. It is mainly endo‐nuclear and situated near ZEB2, positively regulating ZEB2 expression and activating the epithelial mesenchymal transition via the PI3K/Akt/GSK3β/Zeb2 signaling pathway. Meanwhile, EGF‐induced F‐actin polymerization in MDA231 cells can be suppressed by reducing lncRNA‐ZEB2‐AS1 expression. The migration and invasion of triple‐negative breast cancer can be altered through cytoskeleton rearrangement. In summary, we demonstrated that lncRNA‐ZEB2‐AS1 is an important factor affecting the development of triple‐negative breast cancer and thus a potential oncogene target.
Association of non‐surgical periodontal therapy on patients' oral health‐related quality of life—A multi‐centre cohort study
Authors: Peikert Stefanie A. , Spurzem Wilhelm , Vach Kirstin , Frisch Eberhard , Ratka‐Krüger Petra , Woelber Johan P. 
Published: March 2019

AbstractAimThe aim of this multi‐centre cohort study was to investigate the association of non‐surgical periodontal therapy (NST) on the oral health‐related quality of life (OHRQoL) in general and related to severity of periodontal disease and treatment modalities.Materials and MethodsOne hundred and seventy‐two patients with periodontal disease from 18 dental practices were measured before and 6–8 weeks after NST using a standardized and validated OHRQoL instrument (Oral Health Impact Profile‐G14, OHIP‐G14). Another questionnaire was filled out by the dentists to evaluate the influence of treatment modalities and disease severity.ResultsOverall, the mean value of the OHIP baseline improved significantly after NST (p < 0.0001). Furthermore, a significant negative association between the severity of periodontitis and OHRQoL could be detected, and only patients with moderate and severe periodontitis showed a significant improvement of OHIP mean values (p < 0.0001). The results also indicated a significant association of the practitioners (p = 0.0362) as well as treatment modalities (favouring systemic antibiotics, p = 0.0066) regarding the improvement of the patients' OHRQoL.ConclusionThis study showed that NST is positively associated with patients' oral health‐related quality of life. This association seems to depend on the disease severity and caregiver and treatment modality.
Prevalence and predictive factors of dentin hypersensitivity in Brazilian adolescents
Authors: Silva Markelane Santana , Lima Alessandra Noleto de Almeida Nunes , Pereira Marta Maria Alves , Ferraz Mendes Regina , Prado Júnior Raimundo Rosendo 
Published: March 2019

AbstractAimTo measure the prevalence of dentin hypersensitivity (DH) in adolescents.MethodsThe diagnosis was based on self‐report and was confirmed by tactile and evaporative tests. The association between DH and predictor factors was determined using a multivariate model. The sample consisted of 384 adolescents.ResultsThe prevalence was 19.0%. DH prevalence to tactile stimulus was higher in those participants whose toothbrush movement was vertical/horizontal (OR = 0.53, 95% CI = 0.47–0.60, p < 0.001), in the presence of dental biofilm (OR = 2.45, 95% CI = 1.94–3.09, p < 0.001), of non‐carious cervical lesion (OR = 2.76, 95% CI = 2.40–3.18, p < 0.001), of gingival recession (OR = 1.63, 95% CI = 1.44–1.86, p < 0.001) and gyroversion (OR = 1.60, 95% CI = 1.40–1.82; p < 0.001). When DH was diagnosed by evaporative stimulus, there was an association with brush movement in a vertical/horizontal direction (OR = 0.73, 95% CI = 0.66–0.82, p < 0.001), with the use of mouthwash solutions (OR = 2.65, 95% CI = 2.16–3.25, p < 0.001), in the presence of non‐carious cervical lesion (OR = 1.75, 95% CI = 1.57–1.96, p < 0.001), of gyroversion (OR = 1.75, 95% CI = 1.51–1.90, p < 0.001) and gingival recession (OR = 1.78, 95% CI = 1.59–1.99, p < 0.001).ConclusionsThe prevalence of DH in the sample was worrying, since almost 1 in 5 adolescents had DH. Individuals with DH were more likely to report traumatic dental brushing, and presence of dental biofilm, non‐carious cervical lesion, gingival recession and gyroversion in the affected teeth.
Decreased salivary concentration of CD9 and CD81 exosome‐related tetraspanins may be associated with the periodontal clinical status
Authors: Tobón‐Arroyave Sergio Iván , Celis‐Mejía Natalia , Córdoba‐Hidalgo Mónica Patricia , Isaza‐Guzmán Diana María 
Published: March 2019

AbstractAimThis cross‐sectional case–control study was designed to determine the association of the salivary concentration of CD9/CD81 exosome‐related tetraspanins with the periodontal clinical status.Materials and MethodsSaliva samples from 104 periodontitis patients and 45 healthy controls were collected. Periodontal status was assessed based on full‐mouth clinico‐radiographical data, and salivary concentration of the analytes was calculated by ELISA. The association between the biomarkers with disease status was analysed using multivariate binary logistic regression models.ResultsSignificantly decreased salivary levels of CD9 and CD81 exosomes were detected in periodontitis patients in comparison with healthy controls. Also, negative significant correlations between salivary concentrations of CD9/CD81 exosomes regarding clinical measurements were observed. Likewise, a significant downward trend of the concentration of these two biomarkers concerning the stage and grade of disease could be identified. Logistic regression analyses revealed a strong/independent association for decreased salivary concentration of CD81 exosomes regarding disease status. Confounding and interaction effects between age and salivary concentration of CD9 exosomes were also noted.ConclusionReduced salivary concentration of CD9/CD81 exosomes might be of significance in the context of periodontal disease pathogenesis.
Beyond relationship quality: The role of leader–member exchange importance in leader–follower dyads
Authors: Lee Allan , Thomas Geoff , Martin Robin , Guillaume Yves , Marstand Anders F. 
Published: March 2019

In this paper, we introduce a novel construct, leader–member exchange (LMX) importance, which we position as a meta‐perception indicating whether followers view their LMX relationship as personally important or valuable to them. Based on social exchange theory, we examine the extent to which the obligation followers feel towards their leader depends jointly on the quality and the importance of the LMX relationship. We examine how LMX importance influences the process through which LMX quality affects employees’ level of organizational citizenship behaviour (OCB) by focusing on felt obligation (a measure of followers’ reciprocity obligation in the social exchange process) as a mediating variable. Across two studies, we found that high levels of both LMX quality and LMX importance interacted to engender a greater feeling of obligation in followers to repay the perceived favourable exchanges with their leader. Felt obligation predicted leader‐rated OCB, demonstrating support for our hypothesized moderated mediation model. However, psychological empowerment, when included alongside felt obligation (in Study 2), did not mediate the LMX‐OCB relationship. Overall, our findings extend the focus of LMX theory beyond the confines of LMX quality to incorporate the importance of the LMX relationship.Practitioner points

Leaders should be aware that followers vary in the extent to which they perceive the leader–follower relationship to be personally important. As such, they may decide to invest heavily in helping followers understand that the relationship is instrumental for their success at work.

Leaders should invest not only in trying to build positive relationships, but also in establishing the importance of these relationships. Doing so will maximize the benefits of developing a high‐quality relationship.

Followers appear to be more willing to reciprocate when they perceive a high‐quality relationship with the leader and one when they perceive the relationship to be important. Thus, managers should be aware that the norm of reciprocity may vary depending on how important followers perceive the relationship to be and leaders may need to find other ways to motivate employees who do not see the relationship as important.

When followers do not see the leader–follower relationship as important, managers should avoid trying to engage in reciprocity contingent influence tactics and/or try to change followers’ perceptions of the importance of the relationship.
Relational costs of status: Can the relationship between supervisor incivility, perceived support, and follower outcomes be exacerbated?
Authors: Potipiroon Wisanupong , Ford Michael T. 
Published: March 2019

Status has a central role in workplace incivility research. Although status is associated with a variety of benefits at work, we draw upon the relational model of authority and the status maintenance argument to propose that individuals with high status are more strongly affected by the experience of supervisor incivility than those with lower status. We tested this hypothesis by examining the relationships between supervisor incivility and turnover intentions, organizational deviance, and task performance, and proposed that the exacerbating effect of status could be explained by the extent to which employees feel that they are valued, cared for, and supported by their organization and supervisor (i.e., perceived organizational and supervisory support [POS and PSS]). Based on the structural equation modelling (SEM) analyses of supervisor–subordinate dyad data collected from a large organization in Thailand, our findings confirmed that the adverse effects of supervisor incivility on follower outcomes were more pronounced among those with higher status. The results also showed that these effects were differentially mediated by POS and PSS. Whereas POS mediated the effect of supervisor incivility on turnover intentions and organizational deviance, it was found that PSS mediated the effect of supervisor incivility on task performance. Theoretical and practical implications are discussed.Practitioner points

Managers should pay particular attention to the type of relationships they develop with their employees. Our work suggests that rude behaviours from authority figures can contribute to employee turnover intentions, deviant behaviours, and poor performance.

Despite the benefits associated with having high status in the workplace, our findings suggest that high‐status employees are more strongly affected by the experience of supervisory incivility.

To buffer these effects, organizations should create a work environment in which employees feel valued, cared for, and supported. Our findings indicate that the negative aspects of these perceptions are partly responsible for the effects of supervisor incivility.
Gender, leadership, and the display of empathic anger
Authors: Keck Steffen 
Published: March 2019

Three experimental studies with different participant pools examined the effects of displays of empathic anger – anger that is caused by witnessing or learning of harm done to another person – on perceptions of men and women in leadership positions. In contrast to prior work, which focused on expressions of anger regarding personal failure and found double standards that favour men, the results in this study show that displays of empathic anger were significantly more beneficial for female leaders. In particular, female leaders who expressed anger about a harm done to a subordinate were perceived as possessing more agentic and communal characteristics, and as being more effective in their position, than their male counterparts. Moreover, the results showed that this effect was driven by observers’ tendency to attribute empathic anger expressed by female compared with male leaders more strongly to internal reasons like the leader's personality. Consistent with these findings, the different perceptions of male and female leaders were no longer present when attributions for the displays of empathic anger were clearly internal.Practitioner points

To be effective leaders, female managers need to show qualities like determination and confidence, but unlike male leaders, they often find it difficult to do so without simultaneously been judged as lacking important attributes like warmth and kindness.

The results in this study suggest that female leaders can overcome this problem by expressing anger about a harm done to others, which causes observes to judge them even more positively than male leaders who engage in the same behaviour.

Overall, whereas female leaders should generally avoid expressing anger about a personal harm for which they are judged very negatively, they should not be reluctant to display anger about harm done to other members of organization when they have the opportunity to do so.
The effect of a self‐management program on hand‐washing/mask‐wearing behaviours and self‐efficacy level in peritoneal dialysis patients: a pilot study
Authors: Karadag Ezgi 
Published: March 2019

SUMMARYBackgroundSelf‐management of chronic kidney disease (CKD) is crucial for health outcomes.ObjectivesThis study was conducted to demonstrate the effect of a self‐management programme based on Bandura's self‐efficacy theory offered to patients receiving peritoneal dialysis (PD) on behavioural changes regarding hand‐washing/mask‐wearing and self‐efficacy level.DesignIn this study, the pretest‐posttest design was used without a control group.MethodsThe sample of the study consisted of 30 patients who were receiving peritoneal dialysis. At the first interview conducted with patients, patients were given a Questionnaire Form on Socio‐Demographic and Disease Characteristics and the Self‐efficacy Scale. Following the 6‐month self‐management programme; the self‐efficacy scale was applied again and the effectiveness of the self‐management programme was evaluated by re‐asking the questions on hand‐washing and mask‐wearing behaviours, and the two questions on the presence of peritonitis and leucocyte abnormality. The self‐management programme in question in this study was comprised of multidisciplinary team collaboration, telephone contact, clinic interviews, use of reminders, training intervention based on Bandura's self‐efficacy theory and enhancement of self‐efficacy.ResultsA statistically significant difference was found between the pre‐intervention and post‐intervention self‐efficacy scale mean scores of patients (t: −4,396, p < .001).ConclusionsIn this study, it was found that the self‐management programme based on Bandura's self‐efficacy theory caused a positive change in the hand‐washing/ mask‐wearing behaviours of patients and that it improved the self‐efficacy level.
Assessing the Relationship between Neoliberal Ideology and Reactions to Central American Asylum Seekers in the United States
Authors: Dutt Anjali , Kohfeldt Danielle 
Published: March 2019

AbstractAccording to the United Nations, there are approximately 22.5 million refugees in the world and this number is expected to grow due to war and environmental catastrophe. Additionally, contemporary U.S. society is marked by neoliberal ideology, increasingly coupled with nationalist discourses and policies. Noting the current U.S. sociopolitical context, there is great incentive to study how internalization of neoliberal ideology relates to engagement in efforts to support the rights of refugees. In the current study, we examine the relationships between internalized neoliberal ideology, moral exclusion of people seeking asylum from Central America, levels of ethnocentrism, and willingness to engage in efforts to support the human rights of asylum seekers. Participants (N = 270) were recruited through Prolific Academic and responses were analyzed using structural equation modeling. Findings illustrate a strong connection between endorsement of neoliberal ideology and the moral exclusion of Central American asylum seekers, as well as lower levels of willingness to engage in efforts to support the rights of asylum seekers and higher levels of ethnocentrism. Policy implications are discussed.
Orientation and flight behaviour identify the Soprano pipistrelle as a migratory bat species at the Baltic Sea coast
Authors: Lindecke O. , Elksne A. , Holland R. A. , Pētersons G. , Voigt C. C. 
Published: March 2019

AbstractMigration routes of bats remain largely unknown, as previous orientation studies have been challenging even with newly developed techniques in tracking, genetic and stable isotope studies. However, a lack of knowledge about migrations poses problems for species conservation, especially in newly described species for which ecological information is not yet available. Here, we aimed to test flight orientation behaviour in the Soprano pipistrelle, Pipistrellus pygmaeus. This species has been described only 22 years ago but is now known to have a wide geographic distribution in Europe, yet virtually no information exists about seasonal movements of P. pygmaeus. In large parts of the continent, seasonal occurrence of P. pygmaeus matches with that of long‐distance migratory Nathusius' bats (Pipistrellus nathusii). To shed light on the migratory behaviour of both species, we investigated their orientation decisions at the Latvian Baltic Sea coast which is well‐known for summer bat migration along a north‐south axis. We developed an arena‐based assay designed to measure orientation of takeoffs. The arena was installed in the natural flight path of P. nathusii and P. pygmaeus, and after takeoff, bats chose the direction freely. We detected bearing fidelity between takeoff and departure flights, suggesting that bats used cues within the arena, putatively geomagnetic information, which allowed them to set a course prior to takeoff. Furthermore, our results show that P. pygmaeus orientates in a southerly, seasonally appropriate direction, similar to P. nathusii during ongoing migration. Therefore, our findings are consistent with true migratory behaviour of P. pygmaeus in the northern part of its range. Predicting flight directions of bats based on takeoff direction offers a simple test for orientation studies, and could further be used to test senses of bats under varying treatments, thereby facilitating a comparison of navigational skills across taxa, e.g., bats and birds.
Lactate and number of organ failures predict intensive care unit mortality in patients with acute‐on‐chronic liver failure
Authors: Cardoso Filipe S. , Abraldes Juan G. , Sy Eric , Ronco Juan J. , Bagulho Luís , Mcphail Mark J. , Karvellas Constantine J. 
Published: March 2019

AbstractBackground and AimsPatients with acute‐on‐chronic liver failure (ACLF) have high mortality rates. Most prognostic scores were not developed for the intensive care unit (ICU) setting. We aimed to improve risk stratification for patients with ACLF in the ICU.MethodsA training set with 240 patients with cirrhosis and organ failures (Chronic Liver Failure Sequential Organ Failure Assessment score [CLIF‐SOFA]) from Curry Cabral Hospital (Portugal) and University of Alberta Hospital (Canada) in 2010‐2016 was used to derive a prognostic model for ICU mortality. A validation set with 237 patients with cirrhosis and organ failures from Vancouver General Hospital (Canada) in 2000‐2011 was used to evaluate its performance.ResultsAmongst patients in the training set, ICU and hospital mortality rates were 39.2% and 54.6% respectively. Median lactate (4.4 vs 2.5 mmol/L) and number of organ failures (3 vs 2) on admission to ICU were associated with higher likelihood of ICU mortality (P < 0.001 for both). The lactate and organ failures predictive model (LacOF) was derived to predict ICU mortality: −2.420 + 0.072 × lactate + 0.569 × number of organ failures (area under‐the‐curve [AUC], 0.76). In the validation set, the LacOF model discriminative ability (AUC, 0.85) outperformed the CLIF‐SOFA (AUC, 0.79), Chronic Liver Failure Consortium Acute‐on‐Chronic Liver Failure (AUC, 0.73), Model for End‐stage Liver Disease score (AUC, 0.78) and Acute Physiology and Chronic Health Evaluation II scores (AUC, 0.74; P < 0.05 for all). The LacOF model calibration was good up to the 25% likelihood of ICU mortality.ConclusionsIn patients with ACLF, lactate and number of organ failures on admission to ICU are useful to predict ICU mortality. This early prognostic evaluation may help to better stratify the risk of ICU mortality and thus optimize organ support strategies.