bluuebunny/crossref_metadata_2025_split huggingface dataset:
Various Application of Corneal Tattooing
Authors: Jeong Jinho , Fay Jonathan D , Lee Jimmy K , Chuck Roy S , Kwon Ji-won 
Published: December 2018

Abstract
Background: To evaluate the efficacy of corneal tattooing in a large case series.
Methods: The medical charts of 62 eyes of 62 patients who underwent corneal tattooing between March 2016 and August 2017 were retrospectively reviewed. The causes of opacity and various methods of corneal tattooing applied were analyzed.
Results: Among our 62 patients, 38 were male and 24 female. Average age was 48.47±15.30 (range, 12-74)years old. The mean follow-up period was 23.19 ±2.34 (range, 19-27) months. The most common causes of corneal opacity were ocular trauma (33 eyes, 53.2%), prior retinal surgery (9 eyes, 14.5%), congenital etiologies (8 eyes, 12.9%) and measles (5 eyes, 8.0%). The most common associated ocular findings were strabismus (23eyes, 37.0%), phthisis bulbi (17 eyes, 27.4%) and band keratopathy (13 eyes, 20.9%). Cosmetic outcomes improved without serious complications in all cases.
Conclusions: Corneal tattooing is a viable option with an expanding set of indications, such as discolored corneal tattoos, white pupil due to inoperable cataract with clear cornea, and dense corneal opacities in blind eyes. Elective corneal tattooing seems to be a viable and convenient method to improve cosmesis with minimal complications and high patient satisfaction.
New technologies of hypotensive drug delivery in glaucoma treatment
Authors: Kiseleva O. A. , Bessmertny A. M. , Yakubova L. V. 
Published: December 2018

The paper reports on promising methods of drug delivery in glaucoma treatment: contact lenses, punctum plugs, intraocular implants, subconjunctival and supraciliary injections, ocular rings, hydrogels, nanocarriers.
4-Formilbenzoat’ın Co(II), Cu(II) ve Zn(II) ile İzonikotinamid Komplekslerinin Sentezi; Spektroskopik, Termik Özelliklerinin ve Antibakteriyel Etkinliklerinin İncelenmesi
Authors: SERTÇELİK Mustafa , ÖZBEK Füreya Elif , SUGEÇTİ Serkan , NECEFOĞLU Hacali 
Published: December 2018

Bu çalışmada Co(II), Cu(II) ve Zn(II) metallerinin 4-formilbenzoik asit ve izonikotinamid ile üç adet kompleksi sentezlendi: Co(C6H6N2O)2(H2O)4](C8H5O3)2·2H2O, Cu2(C8H5O3)4(C6H6N2O)4, Zn(C8H5O3)2 (C6H6N2O), sentezlenen üç kompleksin yapısı elementel analiz, FT-IR spektroskopisi ve termik analiz ile sonucunda karakterize edildi. Yapıları karakterize edilen komplekslerin Esherishia coli (E. coli) ve Staphylococcus aureus (S. aureus) bakteri türleri üzerinde antibakteriyel özellikleri incelenmiştir.B3 vitamini olarak bilinen nikotinamid’in izomerlerinden biri olan izonikotinamid, γ pozisyonunda amid grubu (-CONH2 ) içeren bir piridin türevidir ve antitüberküloz, ateş düşürücü, fibrinolitik ve antibakteriyel özellikler gösterir (Ahuja and Prasad, 1976; Aguiar ve ark.., 2015). Piridin ve türevlerini içeren kompleksler gösterdikleri biyolojik aktiviteleri sayesinde biyolojik olarak önemli rol oynamaktadır (Kismali ve ark al., 2012). Biyolojik olarak önemli olan bu ligandların metal komplekslerinin bazen serbest ligandlara göre daha etkili olduğu bilinir (Ahuja and Prasad, 1976; Al-Saif and Moamen S. Refat, 2012; Surendra Dilip ve ark, 2016; Altun and Şuözer, 2017). Metal komplekslerinin Esherishia coli, Pseudomonas aeruginosa, Staphylococcus pyogones ve Candida Albicans’a karşı antibakteriyel aktivitelerinin araştırıldığı bir çalışmada
Correlation Between Insulin Levels and Thyroid Hormones in Diabetic Animals After Caffeine Consumption Associated with Exercise
Authors: da Silva Luiz Augusto , Wouk Jéssica , Weber Vinícius Müller Reis , de Almeida Pablo , Martins Julio C.L. , Malfatti Carlos R.M. , Osiecki Raul 
Published: December 2018

Introduction:
Thyroid hormones (TH) are important determinants of glucose homeostasis,
and in contrast, insulin is the first hormone responsible for glycemic control.

Objective:
The objective of the present study was to correlate the levels of insulin and thyroid hormones
in diabetic animals after caffeine consumption associated with physical exercise.

Methods:
A total of 48 animals, 60 days old were allocated in eight experimental groups: Control,
Diabetic, Exercise, Diabetes + exercise, Caffeine, Diabetes + Caffeine, Caffeine + Exercise, and Diabetes
+ Exercise + Caffeine. Diabetes model was induced by intraperitoneal administration of 120
mg/kg of alloxan. On the test day, 6 mg/kg of caffeine was administrated 30 minutes before physical
exercise. After, animals performed a 60 minutes’ session of predominantly aerobic exercise, using an
overload of 6% of their body’s weight. Blood has been collected by a caudal puncture to future insulin,
TSH, T3, and T4 analyses.

Results:
After caffeine treatment and training, insulin values were higher for the control groups
(231%) when compared to the diabetic groups. A significant increase in plasmatic insulin concentration
was found in caffeine group (95%) and Exercise+Caffeine group (56%) when compared to Control
and Exercise groups. TSH values were increased for Diabetes, Diabetes+Caffeine and Diabetes+
Exercise+Caffeine groups (30%) compared to the other groups. A reduction in T4 values occurred
in the animals of groups Diabetes+Exercise and Diabetes +Caffeine (66%) compared to the
Control group. T3 values were significantly increased for the Diabetes+Exercise group (70%) when
compared to the Diabetes+Exercise+Caffeine group.

Conclusion:
Physical exercise and caffeine consumption were able to promote hormonal changes in
diabetic animals after 30 days of training. The study showed a reduction in the serum concentration
of thyroid hormones, but insulin levels were higher.
The Tolerant Immune System: Biological Significance and Clinical Implications of T Cell Tolerance
Authors: Magrone Thea , Jirillo Emilio 
Published: December 2018

Background:
T cell tolerance both at thymic and peripheral levels is a mechanism of protection
finalized to eradicate autoreactive T cell clones and/or to maintain immune homeostasis, especially,
postnatally. Central tolerance occurs in the thymic medulla via a mechanism of negative selection
which leads to the eradication of autoreactive T cell clones.

Mechanisms of Action:
Such a tolerogenic event relies on Fas-mediated apoptosis of autoreactive T
cell clones operated by thymic dendritic cells (DCs), on the one hand. On the other hand, activated
thymic T regulatory (Treg) cells in cooperation with medullary thymic epithelial cells and DCs suppress
autoreactive T cell clones. Peripherally, different types of Treg cells exert the so-called peripheral
tolerance towards autoreactive T cell clones which may have escaped from negative selection
mechanisms. At the same time, peripheral Treg cells activated by tolerogenic DC have antiinflammatory
activities, especially in the intestine towards food and microbial antigens.

Drug Targeting:
Various natural and dietary products, such as vitamins (A, C, D), lactobacilli and
polyphenols will be described for their tolerogenic capacity to attenuate the inflammatory pathway, as
observed in preclinical and clinical studies.
The Inhibitory Role of M2000 (β-D-Mannuronic Acid) on Expression of Toll-like Receptor 2 and 4 in HT29 Cell Line
Authors: Sharifi Laleh , Moshiri Mona , Dallal Mohammad M.S. , Asgardoon Mohammad H. , Nourizadeh Maryam , Bokaie Saied , Mirshafiey Abbas 
Published: December 2018

Background/Objectives:
Anti-inflammatory agents play a crucial role in controlling inflammatory
diseases such as Inflammatory Bowel Disease (IBD) but their use is restricted due to their vast
side effects. M2000 (β-D-mannuronic acid) is a new immunomodulatory drug. According to the capacity
of M2000 in suppressing some molecules involved in Toll Like Receptors (TLRs) signaling and
reducing oxidative stress we hypothesize that, this molecule may have a potential role in decreasing
inflammatory responses in IBD. The aim of this study was to evaluate the cytotoxicity of M2000 and its
effect on the gene expression of TLR2 and TLR4.

Methods:
HEK293 cell line was grown and divided into 96-well cell plate and MTT assay was performed.
HT29 cells were cultured and treated with low and high doses of M2000. Total RNA was extracted
and cDNA synthesized and quantitative real-time PCR was done to quantify the TLR2 and
TLR4 mRNA expression.

Results:
We found that M2000 at the concentration of ≤ 1000µg/ml had no obvious cytotoxicity effect
on the HEK293 cells. Also, low and high doses of M2000 could significantly down-regulate both TLR2
and TLR4 mRNA expression. Moreover, a significant reduction in gene expression of TLR2 and TLR4
in an inflammatory condition resulted in high doses of M2000 in the presence of LPS.

Conclusion:
Our study which was conducted in colonic epithelial cell model, shows that M2000 can be
considered as a new anti-inflammatory agent in IBD. However, more comprehensive experimental and
clinical studies are required to recognize the molecular mechanism of M2000 and also its safety and
efficacy.
Exploring the Role of Mesenchymal Stem Cells During Normothermic Organ Perfusion: A New Paradigm to Enhance Outcome Following Allograft Transplantation
Authors: Morsy Mohamed , Hossain Mohammad Ayaz , Bagul Atul 
Published: December 2018

Background:
Normothermic Machine Perfusion (NMP) has been established in the field of solid organ transplantation for both liver and kidney allografts. The ability to perfuse organs at body temperature enables viability assessment as well as optimisation prior to implantation.

Discussion:
A recent in vitro report of the use of Mesenchymal Stem Cells (MSCs) in the use of a normothermic lung perfusion circuit has raised the possibility of their use in solid organ transplantation. The aim of this short review is to outline the potential uses of bone marrow derived MSCs for their use in renal allograft ex vivo NMP. An overview is provided of current literature of NMP as well as theorised uses for MSCs.
Baker’s Yeast-Based Organocatalysis: Applications in Organic Synthesis
Authors: Sahoo Biswa Mohan , Banik Bimal Krishna 
Published: December 2018

Background:
Catalyst speeds up any chemical reaction without changing the point of the
equilibrium. Catalysis process plays a key role in organic synthesis to produce new organic compounds.
Similarly, organocatalysis is a type of chemical catalysis in which the rate of a reaction is
accelerated by organic catalysts.

Methods:
Organocatalysts have gained significant utility in organic reactions due to their less of sensitivity
towards moisture, readily available, economic, large chiral pool and low toxicity as compared
to metal catalysts. Organocatalysts work via both formations of covalent bonds such as enamine and
iminium catalysis as well as through non-covalent interactions such as in hydrogen bonding. For example,
Bakers’ yeast based organocatalysis is widely used in various organic transformations.

Results:
Baker’s yeast is a fermentation product and used mainly in the preparation of bread dough.
It is produced by aerobic fermentation of yeast strain Saccharomyces cerevisiae. Baker's yeast consists
of enzymes which can reduce a carbonyl group into a hydroxyl group with high yield and thereby
making it suitable for biotransformations in organic synthesis.

Conclusion:
Baker's yeast is widely used as a biocatalyst in various organic reactions such as oxidation,
reduction, condensation, hydrolysis, cyclization, etc. because it is readily available, inexpensive
and easy to handle.
Penerapan Metode Integrasi Teileren-Poject pada Program Inovasi IPTEK dan Kreativitas Guru-Guru Elektronika Industri di SMKN 9 Kabupaten Garut dalam Kegiatan Workshop Aplikasi Mikrokontroller
Authors: Herdiana Budi , Aria Muhammad , Rahajoeningroem Tri , Kurniawan Bobi , Utama Jana , Hartono Budi 
Published: December 2018

Success of workshop activities in community programs can be seen from the results of these activities which are able to improve students' skills to implement their knowledge that had been obtained previously. This program was done at SMKN 9 aimed at providing innovation and enhancing the creativity of teachers' skills in the field of microcontroller systems. Therefore the ability to understand microcontroller system requires supporting facilities such as hardware and software devices than also require a comprehensive and systematic of learning process. The alternative solution to problem is done by collaborating teileren method and project method simultaneously where learning subject is focused on the workshop material step by step before applying it. The expectation from this program is that teachers can get used to and have the ability to design microcontroller systems that can be applied as teaching materials and curriculum development. The accomplishment of this workshop can be measured by pre-test evaluation which shows value >65% and post-test results which shows an average value of >70% with an average index of teacher capacity improvement based on final evaluation >60% compared to the previous test scores.
Processing Collections of Geo-Referenced Images for Natural Disasters
Authors: Loor Fernando , Gil-Costa Veronica , Marin Mauricio 
Published: December 2018

After disaster strikes, emergency response teams need to work fast. In this context, crowdsourcing has emerged as a powerful mechanism where volunteers can help to process different tasks such as processing complex images using labeling and classification techniques. In this work we propose to address the problem of how to efficiently process large volumes of georeferenced images using crowdsourcing in the context of high risk such as natural disasters. Research on citizen science and crowdsourcing indicates that volunteers should be able to contribute in a useful way with a limited time to a project, supported by the results of usability studies. We present the design of a platform for real-time processing of georeferenced images. In particular, we focus on the interaction between the crowdsourcing and the volunteers connected to a P2P network.
METODE PEMBANGKITAN IDE KREATIF DALAM PENCIPTAAN SENI
Authors: Eskak Edi 
Published: December 2018

Ide merupakan konsep pemikiran yang akan diwujudkan menjadi karya, tanpa ideseniman tidak akan bisa menciptakan karya seni. Ide menjadi penting karena merupakan titiktolak menciptakan suatu karya seni, namun dalam mengeksplorasi ide, banyak senimanterkendala dalam menemukan ide yang akan dituangkan menjadi karya. Maka perlu dikajiberbagai metode pembangkitan ide kreatif dari berbagai sumber yang dapat diaplikasikanguna membangkitkan ide-ide baru dalam penciptaan seni. Metode yang dikaji adalah:membaca, observasi, curah gagasan, berpikir lateral, serta bersosialisasi dan berdiskusi,Membaca meningkatkan pengetahuan dan memperluas wawasan. Observasi merupakanupaya mendapatkan pengetahuan baru yang mendalam dengan pengamatan, sehinggaseniman mendapatkan ide-ide baru. Bila mengalami ketiadaan ide, seniman dapat melakukancurah gagasan yang dilakukan secara bebas sehingga dapat terhindar dari kebuntuan ide.Berpikir lateral merupakan cara penyegaran pikiran dengan mencoba keluar dari kotakkemapanan, rutinitas, atau dari penjara idiologi, agar menemukan ide inovatif dalampenciptaan seni. Bersosialisasi dan berdiskusi memperbanyak teman untuk bertukar pikiranserta mendapatkan pengalaman yang inspiratif. Kata kunci: ide, kreativitas, dan penciptaan seni, The idea is the concept of thinking translated into the work. An artist will not be able to createart work with no idea. The idea is a starting point to create an art work so that become as animportant issue. However in exploring the idea, many artists are constrained in finding it sothat will be poured into the work. Then it is necessary to study various methods of generatingcreative ideas from a variety of sources that can be applied in order to generate new ideas inthe creation of art. The methods studied were: reading, observation, brainstorming, lateralthinking, as well as socializing and discussion. Reading increases knowledge and broaden yourhorizons. Observation is an effort to gain a profound new knowledge, so the artists get newideas. When experiencing lack of ideas, artists brainstorming ideas can be freely made in orderto avoid deadlock ideas. Lateral thinking is a way of refreshing the mind trying to get out of thebox stability, routine, or the ideology, in order to find innovative ideas in the creation of art.Socializing and discusing multiply with friends to exchange ideas and getting inspirativeexperiences. Keywords: ideas, creativity, and artistic creation.
POTENSI PENGEMBANGAN INOVASI DESAIN PRODUK KRIYA KUKM INDONESIA DI ERA INDUSTRI KREATIF
Authors: Wicaksono Agung 
Published: December 2018

Craft product design innovation can be done starting from the manufacture of itsdesign concept which refers to changes in consumers . Craft products that have cultural base inthe community greatly burdened by tradition philosophical values . Changes in product designis very evolutive or tend to be very slow and has particularly certain patterns . Craft productsproduced as commodities to meet the needs of consumers tend to run relatively more dynamic. The main key change lies in HR culprit who have the will and skill to innovate the design ofproducts that have added value better again . The Indonesian people have the capital to makechanges in product design kriyanya . Openness to information and valuable cultural heritageare the two most important factors in product design innovation craft . Keywords : design innovation , product craft , creative industries Inovasi desain produk kriya dapat dilakukan mulai dari pembuatan konsepperancangannya yang mengacu pada perubahan konsumennya. Produk kriya yang memilikibasis budaya dalam komunitas masyarakat tradisi sangat dibebani oleh nilai-nilai filosofis.Perubahan desain produknya sangat evolutif atau cenderung sangat lambat dan meiliki polapolatertentu. Produk kriya yang dihasilkan sebagai komoditas untuk memenuhi kebutuhankonsumen cenderung berjalan relatif lebih dinamis. Kunci utama perubahan terletak pada SDMpelakunya yang memiliki kemauan dan keterampilan untuk menginovasi desain produk supayamemiliki nilai tambah yang lebih baik lagi. Bangsa Indonesia memiliki modal untuk membuatperubahan pada desain produk kriyanya. Keterbukaan terhadap informasi dan warisan budayaadiluhung merupakan dua faktor penting terjadinya inovasi pada desain produk kriya. Kata kunci : inovasi desain, produk kriya, industri kreatif
APLIKASI KERAMIK PADA FUNGSI AROMATHERAPY
Authors: Sudiyati Noor 
Published: December 2018

Aromatherapy obtained through combustion of essential oil as the need of health isnow mushrooming in big cities. Essential oil that made of plants has the ability to createrelaxation without causing any side effect. Those herbal such as roses, ginger, jasmine, lemongrass and so on are growing around us and treated with distilled technology.Essential oils can be processed into liquid, stick, and solid, and its use requires aceramic container made of clay. Ceramics is capable to answer the needs of aromatherapyfurnace with such a wide variety of themes, images, expressions and artistic decorations.Frangipani themed ceramic furnace is made for aromatherapy containers used for essentialliquids that are heated with candles burning. This furnace made with incorporated slabtechniques so it has unique character.Key words: Ceramic, Aromatherapy, Herbal theme, aromatherapy, for firing,frangipaniceramic. Kebutuhan akan kesehatan melalui system pembakaran mintak atsiri disebutaromatherapy yang berasal dari herbal marak di kota-kota besar, Minyak atsiri yang terbuatdari tumbuh-tumbuhan ternyata mampu membuat rileksasi, dipakai tanpa meninggalkan efeksamping. Herbal itu banyak tumbuh di sekeliling kita, namun diolah dengan teknologi suling,misalnya saja: bunga kenanga, melati (jasmine), sere, Jahe, mawar dan lain sebagainya.Minyak atsiri (aromatherapy) bisa diolah sehingga dapat berupa cairan, stick, danpadat, dalam penggunaanya memerlukan wadah berupa keramik yang terbuat dari Tanah liat.Keramik mampu menjawab kebutuhan wadah pembakaran atau tungku aromatherapi denganberbagai macam: tema, imaji, ekpresi dan dekorasi yang artistic.Tungku Keramik bertema Kamboja dibuat untuk wadah aromatherapy yang dipakaiuntuk atsiri cairan yang dipanaskan dengan pembakaran lilin. Tungku ini dibuat dengan teknikslab yang digabungkan, menjadi tungku yang berkarakter khas. Kata Kunci: keramik, aromatherapy, herbal, pemanasan, tema kamboja.
IMPRESIF BATU ALAM (Sebuah Kajian Kerajinan Batu Alam di Desa Ngeposari Kecamatan Semanu Kabupaten Gunungkidul Yogyakarta)
Authors: Susila Dwi Agus 
Published: December 2018

Impressive is the can deliver or leave a deep impression. However, the processof making the work remains on track to exploit the advantages of natural human thought thatcould be the effect on the senses. In this study raised the utilization of white stones that arefound in the mountainous area of Gunung. The resulting work is complete on the interior andexterior space in the form of floor tiles, wall tiles, reliefs, various masks, candle holder,decorative table, various forms of trim and flower vaseNatural stone contained in Ngeposari, Gunungkidul can we encountered along the hillsthat line the long and wide. In the area there are rocks that can be weighed and the communitynamed palimanan stone white, yellow palimanan stone, stone palimanan doreng, sandstoneregular Jogja, Yogya super sandstone, sandstone Jogja doreng, stone temples and stone graygreen bark. The rock types by Educate Kardiyono processed and formed into products ofeconomic value so as to raise the welfare of the surrounding community. Keywords: Impressive, natural stone Impresif dapat memberikan atau meninggalkan kesan yang mendalam. Namundemikian proses pembuatan karya tetap pada jalur memanfaatkan kelebihan alam pikirmanusia yang bisa berupa efek pada panca inderanya. Pada kajian ini mengangkatpemanfaatan batu putih yang banyak ditemukan di pegunungan daerah Gunungkidul. Karyayang dihasilkan merupakan kelengkapan pada ruang interior dan eksterior yang berupa tegellantai, tegel dinding, relief, aneka topeng, tempat lilin, meja hias, berbagai bentuk lis dan vasbunga.Batu alam yang terdapat di Ngeposari, Kabupaten Gunungkidul bisa kita temuidisepanjang bukit yang berderet panjang dan luas. Pada daerah tersebut terdapat batu-batuanyang bisa ditambang dan oleh masyarakat diberi nama batu palimanan putih, batu palimanankuning, batu palimanan doreng, batu paras jogja biasa, batu paras jogja super, batu paras jogja doreng, batu candi abu-abu dan batu ijo pule. Jenis batu tersebut oleh Didik Kardiyonodiolah dan dibentuk menjadi produk yang bernilai ekonomi sehingga mampu mengangkatkesejahteraan masyarakat disekitarnya.Kata Kunci: Impresif, Batu Alam.