bluuebunny/crossref_metadata_2025_split huggingface dataset:
Codesigning training for health providers to improve detection and response to elder abuse
Authors: Brijnath Bianca , Cavuoto Marina G , Feldman Peter , Dow Briony , Antoniades Josefine , Ostaszkiewicz Joan , Nakrem Sigrid , Stevens Catriona , Reyes Patricia , Renshaw Gianna , Peters Micah D J , Gilbert Andrew , Manias Elizabeth , Mortimer Duncan , Enticott Joanne , Cooper Claudia , Durston Cheryl , Appleton Brenda , O’Brien Meghan , Eckert Marion , Markusevska Simona 
Published: October 2024

Abstract

Background and Objectives
Screening for elder abuse can improve detection, but many health providers lack the necessary skills and confidence. To address this, training for health providers on elder abuse screening was co-designed as part of a trial aimed at improving elder abuse detection and response.

Research Design and Methods
Between March and April 2023, 7 health providers and 10 older people and family carers participated in two national Australian online codesign workshops. Using the World Café method, discussions focused on what knowledge and skills health providers needed for screening; clinical and social issues affecting screening and referral; and support older people needed throughout the process. Data were thematically analyzed.

Results
Participants said health providers should take a trauma-informed, person-centered approach to screening, and explain the limits of confidentiality to older people. Clinical, social, and systemic issues such as dementia, ethnic diversity, and housing availability complicated screening and referrals. To facilitate disclosure, participants said health providers needed to reflect on whether they held ageist views. There were differing opinions on the length of the training and if all health providers or only social workers should screen for abuse.

Discussion and Implications
Participants’ feedback on trauma-informed care, consent, and cognitive impairment concorded with evidence on best practice responses to elder abuse and were integrated in the training. Given operational constraints in health services, feedback from health providers about the training length and the inclusion of all health providers in screening were prioritized. The training is being evaluated in a national trial.
Risks and Outcomes of New Onset of Unmet Need for Mobility and Self-Care Daily Activities
Authors: Sands Laura P , Lee Lina , Zhu Xiaofan , Khan Maham , Du Pang 
Published: October 2024

Abstract

Background and Objectives
Among community-living older adults who have limitations in completing activities of daily living (ADLs), unmet need occurs when they cannot complete an ADL task because no one was available to help. Prior research described correlates of existing unmet needs but did not consider which older adults are at risk for new onset of unmet needs. This study assessed health characteristics that increased risk for new onset of unmet needs within a year and subsequent health outcomes.

Research Design and Methods
Data are from 2011 to 2019 annual interviews of the National Health and Aging Trends Study. For each pair of 2 consecutive annual interviews, we determined whether new onset of unmet needs occurred between the first and second consecutive interviews. Mixed effects logistic regression models were computed to assess risks for new onset of unmet need across 14,890 paired observations from persons who needed help with mobility tasks and 12,514 paired observations from persons who needed help with self-care tasks.

Results
Although demographic characteristics and chronic conditions had modest associations with new onset of unmet need, hospitalization between the 2 consecutive interviews was associated with a twofold increase in risk for new onset of unmet need. New onset of unmet need was associated with hospitalization, nursing home placement, and death in the year following the 2 consecutive annual interviews.

Discussion and Implications
The findings inform the need for frequent assessments of ADL care needs with the goal of preventing new onset of unmet needs, especially after hospitalization.
Non–Exercise-Based Interventions to Support Healthy Aging in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Koh Wei Qi , Wora Nutyathun , Liong Natasha Wing Laam , Ludlow Kristiana , Pachana Nancy A , Liddle Jacki 
Published: October 2024

Abstract

Background and Objectives
Healthy aging is a multidimensional construct, where various factors play a role in influencing well-being in older age. Many studies heavily emphasize the importance of physical activity, negating other aspects such as psychosocial or cognitive influences. This review aimed to evaluate the effectiveness of non-exercise-based interventions on the quality of life (QoL) and life satisfaction of community-dwelling, healthy older adults.

Research Design and Methods
A systematic review and meta-analysis of randomized controlled trials was conducted. Four electronic databases were searched from inception. Three independent reviewers screened the articles and appraised the risk of bias. Data relating to study characteristics, interventions, and outcomes were extracted. The mean difference and standardized mean difference with 95% confidence intervals (CI) were synthesized to pool effect sizes. Outcomes that could not be included in the meta-analysis were synthesized narratively.

Results
Thirty-six articles from 35 randomized controlled trials, involving 6,127 older adults, were included. Most were multicomponent interventions and involved supporting lifelong learning. Most participants were females (70.2%). Pooled analyses revealed small but statistically significant effects on overall QoL (standardized mean difference [SMD] = 0.26, CI: 0.00 to 0.53), and QoL subscales relating to mental health and psychological well-being (SMD = 0.26, CI: 0.12 to 0.41) and environment (SMD = 0.31, CI: 0.03 to 0.58). Effects on social health and functioning, and role functioning related to physical health were marginal. There were no improvements in other subscales. Results revealed nonstatistically significant improvements in life satisfaction.

Discussion and Implications
Multicomponent non-exercise-based interventions that support lifelong learning in older adults can support healthy aging, particularly in improving overall QoL, and mental health, social health, and environment QoL subscales.
Efficacy and safety of lumateperone for bipolar depression and schizophrenia: a systematic review and meta-analysis
Authors: Peng Hanrui , Yan Kewen , Liu Shouhuan , Li Xin , Wang Xin , Peng Pu , Li Xueyi , Wu Min , Xu Huixue , Wu Qiuxia , Liu Tieqiao , Li Zejun 
Published: October 2024

Abstract
This study aimed to evaluate the efficacy and safety of lumateperone in treating bipolar disorder and schizophrenia. A comprehensive literature search was conducted across multiple databases and websites from inception to July 16, 2024, to identify both published and unpublished randomized controlled trials (RCTs). Meta-analyses were performed using random-effects or fixed-effects models depending on statistical heterogeneity. Relative risks (RRs) or standardized mean differences (SMDs) with 95% confidence intervals (CIs) were used to summarize the effects. Out of 931 records screened, 7 RCTs (four focusing on bipolar depression and 3 on schizophrenia) were eligible for inclusion. Lumateperone was efficacious in reducing depressive symptoms in bipolar depression (SMDs = −0.36, 95% CI: −.59 to −.13). In treating schizophrenia, lumateperone exhibited a lower combined SMD of -0.14 (95% CI: −.27 to 0, P = .051, I² = 49.6%), showing no significant difference from the placebo group, although the P-value approached significance. The lumateperone group showed significantly higher response rates compared with placebo in both bipolar depression (RRs = 1.27, 95% CI = 1.07 to 1.51) and schizophrenia (RRs = 1.44, 95% CI = 1.12 to 1.86). Common treatment-emergent adverse events included somnolence, dry mouth, dizziness, nausea, and headache (RRs = 1.30 to 3.29). Importantly, lumateperone did not significantly increase extrapyramidal symptoms (EPS, RRs = 1.46, 95% CI = .84 to 2.53). Lumateperone is effective in treating bipolar depression but does not significantly reduce symptom severity in schizophrenia. It has a favorable safety and tolerability profile. However, caution is warranted in interpreting these findings due to the limited number of studies included.
Experience with expanded use of oritavancin in a tertiary hospital: indications, tolerability and outcomes
Authors: Bandaranayake Thilinie Dulanjalee , Radcliffe Christopher , Cvercko Melanie , Golden Marjorie , Hao Ritche Manos 
Published: October 2024

Abstract

Background
Oritavancin is a lipoglycopeptide antibacterial agent used to treat infections caused by Gram-positive organisms. It is FDA-approved for the treatment of acute bacterial skin and soft tissue infections (ABSSIs) but is increasingly being used off-label to treat invasive bacterial infections such as osteomyelitis, prosthetic joint infection and infective endocarditis.

Objectives
This study describes the clinical outcomes and adverse reactions related to oritavancin.

Patients and methods
This was a retrospective study conducted over a 5 year period at a tertiary care medical centre. Ninety-five adult patients were included in this study and were followed for 1 year after the last dose of oritavancin.

Results
The most common indication for oritavancin at our institution was osteomyelitis, followed by ABSSI. Other indications were vertebral infection, hardware-associated infection, bacteraemia and infective endocarditis. Fourteen percent (13/95) of patients developed an adverse reaction to oritavancin during the study period. Cure with no recurrence up to 1 year after the last dose of oritavancin was achieved in 74% (53/71) of patients, and the treatment failure rate was 19% (14/71 patients).

Conclusions
Oritavancin is an effective agent that can be used to treat invasive Gram-positive bacterial infections other than ABSSI. Adverse events requiring drug discontinuation were common.
Quality of life improvement after radiotherapy for bone metastases assessed using real-world data: a secondary analysis of a Nationwide Multicenter Cohort Study
Authors: Utsumi Nobuko , Saito Tetsuo , Shikama Naoto , Takahashi Takeo , Harada Hideyuki , Nakamura Naoki , Ueno Shuichi , Notsu Akifumi , Shirato Hiroki , Yamada Kazunari , Uezono Haruka , Koide Yutaro , Kubota Hikaru , Yamazaki Takuya , Ito Kei , Heianna Joichi , Okada Yukinori , Tonari Ayako , Katoh Norio , Wada Hitoshi , Ejima Yasuo , Yoshida Kayo , Kosugi Takashi , Takahashi Shigeo , Komiyama Takafumi , Uchida Nobue , Miwa Misako , Watanabe Miho , Nagakura Hisayasu , Ikeda Hiroko , Asakawa Isao , Shigematsu Naoyuki 
Published: October 2024

Abstract

Objective
Single-center studies or randomized controlled trials have evaluated the impact of radiotherapy for bone metastases on quality of life (QOL). We investigated the real-world impact of radiotherapy for bone metastases on QOL using nationwide multicenter cohort data.

Methods
We conducted a prospective observational study at 26 centers in Japan. Of 333 patients who received radiotherapy for bone metastases between December 2020 and March 2021, 232 (70%) were enrolled in the study. Patient-reported QOL was evaluated at enrollment and at two- and six-month follow-up using the European Organization for Research and Treatment of Cancer (EORTC) QOL Questionnaire Core 15-Palliative and the EORTC QOL Questionnaire Bone Metastases module (QLQ-BM22). Possible predictors (patient-, tumor -, and treatment-related factors) of QOL improvement were screened using logistic regression models.

Results
QOL scores showed significant improvement at two-month follow-up in seven (global health status/QOL, emotional functioning, pain, insomnia, painful sites, pain characteristics and functional interference) of the 14 scales. Of these seven scales, mean improvement ≥ the minimal clinically important difference (defined by a change of 10 or more on the 0 to 100 scale) was seen in four scales (pain, insomnia, pain characteristics and functional interference). We did not find any predictors of QOL improvement in the functional interference scale of QLQ-BM22.

Conclusion
Radiotherapy for bone metastases performed in daily practice is effective in improving some scales of QOL.
Enhancing 3D planetary atmosphere simulations with a surrogate radiative transfer model
Authors: Tahseen Tara P A , Mendonça João M , Yip Kai Hou , Waldmann Ingo P 
Published: October 2024

ABSTRACT
This work introduces an approach to enhancing the computational efficiency of 3D atmospheric simulations by integrating a machine-learned surrogate model into the oasis global circulation model (GCM). Traditional GCMs, which are based on repeatedly numerically integrating physical equations governing atmospheric processes across a series of time-steps, are time-intensive, leading to compromises in spatial and temporal resolution of simulations. This research improves upon this limitation, enabling higher resolution simulations within practical time frames. Speeding up 3D simulations holds significant implications in multiple domains. First, it facilitates the integration of 3D models into exoplanet inference pipelines, allowing for robust characterization of exoplanets from a previously unseen wealth of data anticipated from JWST and post-JWST instruments. Secondly, acceleration of 3D models will enable higher resolution atmospheric simulations of Earth and Solar system planets, enabling more detailed insights into their atmospheric physics and chemistry. Our method replaces the radiative transfer module in oasis with a recurrent neural network-based model trained on simulation inputs and outputs. Radiative transfer is typically one of the slowest components of a GCM, thus providing the largest scope for overall model speed-up. The surrogate model was trained and tested on the specific test case of the Venusian atmosphere, to benchmark the utility of this approach in the case of non-terrestrial atmospheres. This approach yields promising results, with the surrogate-integrated GCM demonstrating above 99.0 per cent accuracy and factor of 147 speed-up of the entire simulation executed on one graphics processing unit (GPU) compared to using the matched original GCM under Venus-like conditions.
SSBD: an ecosystem for enhanced sharing and reuse of bioimaging data
Authors: Kyoda Koji , Itoga Hiroya , Yamagata Yuki , Fujisawa Emi , Wang Fangfang , Miranda-Miranda Miguel , Yamamoto Haruna , Nakano Yasue , Tohsato Yukako , Onami Shuichi 
Published: October 2024

Abstract
SSBD (https://ssbd.riken.jp) is a platform for the sharing and reuse of bioimaging data. As part of efforts to build a bioimaging data ecosystem, SSBD has recently been updated to a two-tiered data resource comprising SSBD:repository, a public repository for the sharing of all types of bioimaging data reported in journals, and SSBD:database, an added-value database for the sharing of curated, highly reusable, metadata-rich data. This update addresses the conflicting demands of rapid data publication and sharing of richly annotated data, thereby promoting bioimaging data sharing and reuse. With this update, SSBD is now positioned as a core repository and database within the foundingGIDE, an international consortium working to establish a global image data ecosystem. Harmonizing metadata between data resources enables cross-searching and data exchange with data resources from other countries and regions.
Primed to persevere: Hypoxia regulation from epigenome to protein accumulation in plants
Authors: Gibbs Daniel J , Theodoulou Frederica L , Bailey-Serres Julia 
Published: October 2024

Abstract
Plant cells regularly encounter hypoxia (low-oxygen conditions) as part of normal growth and development, or in response to environmental stresses such as flooding. In recent years, our understanding of the multi-layered control of hypoxia-responsive gene expression has greatly increased. In this Update, we take a broad look at the epigenetic, transcriptional, translational, and post-translational mechanisms that regulate responses to low-oxygen levels. We highlight how a network of post-translational modifications (including phosphorylation), secondary messengers, transcriptional cascades, and retrograde signals from the mitochondria and endoplasmic reticulum (ER) feed into the control of transcription factor activity and hypoxia-responsive gene transcription. We discuss epigenetic mechanisms regulating the response to reduced oxygen availability, through focussing on active and repressive chromatin modifications and DNA methylation. We also describe current knowledge of the co- and post-transcriptional mechanisms that tightly regulate mRNA translation to coordinate effective gene expression under hypoxia. Finally, we present a series of outstanding questions in the field and consider how new insights into the molecular workings of the hypoxia-triggered regulatory hierarchy could pave the way for developing flood-resilient crops.
Ultrasound-mediated cardiovascular thrombolysis: from Sonothrombolysis to Sonoperfusion
Authors: Jiang Zhixin , Jiang Nan , Wang Zhiwen , Deng Qing , Zhou Qing , Hu Bo 
Published: October 2024

Abstract
The incidence of coronary artery disease has been increasing in recent years, with acute myocardial infarction as its most severe onset. The major aim for clinical treatment is to restore myocardial blood supply with the recanalization of coronary circulation as early as possible, while the still existed issue of microcirculation thromboembolism has become a serious obstacle. Thus, thrombus elimination in coronary microcirculation is crucial and essential to improve the treatment outcome of acute myocardial infarction. In recent years, from sonothrombolysis to sonoperfusion, ultrasound-mediated cardiovascular thrombolysis can effectively solve the problem of vascular thromboembolism, including microcirculation thromboembolism, and the treatment method is expected to obtain satisfied thrombolytic treatment effect with microthrombus elimination in coronary microvessels and function recovery of terminal microcirculation, which has potential clinical value for the establishment of novel treatment for coronary thromboembolism. Therefore, this paper reviews ultrasound-mediated cardiovascular thrombolysis including sonothrombolysis and sonoperfusion for the application exploration in the treatment of coronary artery thromboembolism, the mechanism of action, and its research progress.
Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity
Authors: Jiang Jing , Ferraro Stefania , Zhao Youjin , Wu Baolin , Lin Jinping , Chen Taolin , Gao Jin , Li Lei 
Published: October 2024

Abstract
Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are common stress-related psychiatric disorders. Genetic and neurobiology research has supported the viewpoint that PTSD and MDD may possess common and disorder-specific underlying mechanisms. In this systematic review, we summarize evidence for the similarities and differences in brain functional and structural features of MDD, PTSD, and their comorbidity, as well as the effects of extensively used therapies in patients with comorbid PTSD and MDD (PTSD + MDD). These functional magnetic resonance imaging (MRI) studies highlight the (i) shared hypoactivation in the prefrontal cortex during cognitive and emotional processing in MDD and PTSD; (ii) higher activation in fear processing regions including amygdala, hippocampus, and insula in PTSD compared to MDD; and (iii) distinct functional deficits in brain regions involved in fear and reward processing in patients with PTSD + MDD relative to those with PTSD alone. These structural MRI studies suggested that PTSD and MDD share features of reduced volume in focal frontal areas. The treatment effects in patients with PTSD + MDD may correlate with the normalization trend of structural alterations. Neuroimaging predictors of repetitive transcranial magnetic stimulation response in patients with PTSD + MDD may differ from the mono-diagnostic groups. In summary, neuroimaging studies to date have provided limited information about the shared and disorder-specific features in MDD and PTSD. Further research is essential to pave the way for developing improved diagnostic markers and eventually targeted treatment approaches for the shared and distinct brain alterations presented in patients with MDD and PTSD.
Expectations and Learning from Prices
Authors: Bastianello Francesca , Fontanier Paul 
Published: October 2024

Abstract
We study mislearning from equilibrium prices, and contrast this with mislearning from exogenous fundamentals. We micro-found mislearning from prices with a psychologically founded theory of “Partial Equilibrium Thinking” (PET), where traders learn fundamental information from prices, but fail to realize others do so too. PET leads to over-reaction, and upward sloping demand curves, thus contributing to more inelastic markets. The degree of individual-level over-reaction and the extent of inelasticity vary with the composition of traders, and with the informativeness of new information. More generally, unlike mislearning from fundamentals, mislearning from prices (i) generates a two-way feedback between prices and beliefs that can provide an arbitrarily large amount of amplification and (ii) can rationalize both over-reaction and more inelastic markets. The two classes of biases are not mutually exclusive. Instead, they interact in very natural ways, and mislearning from prices can vastly amplify mislearning from fundamentals.
Dermal Microcoring for Skin Laxity, Rhytides, and Scars
Authors: Hashemi David A. , Tao Joy , Wang Jordan V. , Munavalli Girish , Geronemus Roy G. 
Published: October 2024

BACKGROUND
Dermal microcoring extracts cores of skin that are small enough to allow healing in a scarless fashion. Its use has been reported in the treatment of skin laxity, rhytides, and textural abnormalities.

OBJECTIVE
To report the authors' clinical experience using dermal microcoring in a variety of cases.

MATERIALS AND METHODS
A retrospective chart review was performed looking at dermal microcoring cases for any indication between August 2022 and March 2024.

RESULTS
Thirty-eight patients were treated. Overall, 32 (84.2%) patients were women, with median age of 67 years (R: 20–80 years). Fitzpatrick skin types I to V were represented. Among patients with adequate photographs for review, improvements of grade 3 and 4 (good and excellent) were seen in 85.7% (n = 18/21) treated for skin laxity and rhytides, 50.0% (n = 3/6) treated for acne scars, 66.7% (n = 2/3) treated for traumatic or surgical scars, and 100.0% (n = 3/3) treated for foreign material. Six (15.4%) patients experienced erythema or hyperpigmentation lasting more than 4 weeks, and 2 (5.1%) patients experienced temporary focal scarring, which improved with intralesional therapy and laser treatment. No patients experienced permanent dyspigmentation, prolonged edema, or infection.

CONCLUSION
Dermal microcoring has been demonstrated to safely and effectively treat skin laxity, rhytides, scars, and foreign material.