bluuebunny/crossref_metadata_2025_split huggingface dataset:
The implementation and evaluation of a family‐led novel intervention for delirium prevention and management in adult critically ill patients: A mixed‐methods pilot study
Authors: Johnson Gideon U. , Towell‐Barnard Amanda , McLean Christopher , Ewens Beverley 
Published: December 2024

AbstractBackgroundFamily‐led interventions have been identified as effective in many areas of care including the management of delirium. However, because of the heterogeneity and ambiguity of family‐led interventions, they are not consistently applied within intensive care units. A user‐friendly digital intervention may therefore support consistent family integration into delirium management.AimTo explore the feasibility and acceptability of a family member's voice reorientation intervention for delirium prevention and management in an adult intensive care unit.Study DesignParallel, convergent mixed‐methods pilot study was conducted in a general adult intensive care unit in the United Kingdom. Thirty participants (15 patients and 15 family members) were enrolled in the study. For the qualitative component, 17 participants (three patients, six family members and eight nurses) contributed to the evaluation.ResultsThe median frequency of the family member's voice reorientation intervention was 2.3 times per day (range 3.3), and the median Richmond Agitation‐Sedation Scale score was −1 (range 2.5). Qualitative data revealed seven themes: acceptance of the intervention, communication, delirium awareness, reactions to the intervention, cognitive state, perception of the intensive care unit and psychological well‐being.ConclusionNurses can involve family members in person‐centred care within the intensive care unit. Results from this study indicate that the family member's voice reorientation programme is feasible and acceptable and may be an effective strategy for providing ongoing orientation, reassurance and comfort to critically ill adult patients to prevent or manage delirium. A larger study is needed to evaluate its impact on delirium.Relevance for Clinical PracticeThe family member's voice reorientation intervention offers critical care nurses a feasible, family‐centred approach to support delirium care in the intensive care unit. Integrating this non‐invasive tool into practice may enable nurses to enhance patient outcomes, reduce anxiety and strengthen collaboration between patients, families and health care professionals.
Electroacupuncture at Zusanli (ST36) Alleviate Intestinal Ischemia‐Reperfusion Injury by Regulating the Cholinergic‐miRNA 124 Pathway
Authors: Geng YanXia , Lv Hai , Liu Yu , Guo DingDing , Zheng JingJing , Li YingXin , Jiang Hua , Chen Dong 
Published: December 2024

ABSTRACTObjectiveIntestinal ischemia‐reperfusion injury (IIRI) is common in a variety of critical diseases and acute stress, and acupuncture is a promising treatment for IIRI. The aim of this study is to explore the mechanism of electroacupuncture (EA) at Zusanli (ST36) in improving IIRI from the perspective of the cholinergic anti‐inflammatory pathway (CAP) and miRNA 124.MethodsSeven groups of mice were performed: Control group, I/R group (IIRI model), EA group (I/R + EA), miRNA mimic group (I/R + EA + miRNA 124 mimic), miRNA inhibitor group (I/R + EA + miRNA 124 inhibitor), PNU group (I/R + EA + α7nAChR agonist), and MLA group (I/R + EA+ α7nAChR antagonist). The expression of intestinal macrophages, α7nAChR, miRNA 124, and related molecules, including p‐STAT3 and IL‐6, as well as histological damage (Chiu's score) and mucosal permeability (serum FD4 concentration), were detected.ResultsThe serum FD4 concentrations in the EA and PNU groups were significantly lower compared to the I/R group (p < 0.05). The expression of intestinal α7nAChR and miRNA 124 in the EA, miRNA mimic, and PNU groups was higher than that in the I/R group (p < 0.05), while levels of p‐STAT3 and IL‐6 were reduced (p < 0.05). Conversely, in the miRNA inhibitor and MLA groups, miRNA 124 levels were significantly lower than in the EA group (p < 0.05), and IL‐6 levels were increased (p < 0.05).ConclusionEA at Zusanli may induce miRNA124 through the cholinergic pathway on intestinal macrophages, which may be a key neuro‐immune target of EA in the treatment of IIRI.
Interstitial Cells of Cajal Are Required for Different Intestinal Motility Responses Induced by Acupuncture
Authors: Du Longhua , Qin Qingguang , He Xun , Wang Xiaoxi , Sun Guang , Zhu Bing , Liu Kun , Gao Xinyan 
Published: December 2024

ABSTRACTBackgroundThe movement of intestinal smooth muscle is regulated by the external autonomic nervous system (ANS) and its internal enteric nervous system (ENS). Previous studies have shown that acupuncture has a bidirectional regulating effect on intestinal motility through the sympathetic and vagal ANSs. ENS can independently regulate the sensory, secretory, and motor functions of the intestine. The interstitial cells of Cajal (ICC), the pacemaker cells in ENS, play a key role in maintaining gastrointestinal motility. However, studies on the role and mechanism of ICC in the regulation of intestinal function by acupuncture are still unclear.MethodsTo investigate the effect of ICC on the regulation of intestinal motility by manual acupuncture (MA), we recorded the pressure of warm water‐filled manometric balloons in duodenum, jejunum, and distal colon in ICC deficiency WsWs−/− rats and wild‐type littermates WsRC+/+ rats, and performed MA at ST25 (Tianshu), ST37 (Shangjuxu), LI11 (Quchi), and BL25 (Danchangshu) acupoints. Furthermore, the excretion of phenol red in feces before and after MA at ST37 or ST25 was assessed.Key ResultIn WsRC+/+ rats, MA at ST37, LI11, and BL25 promoted duodenal, jejunal, and distal colon motility, whereas MA at ST25 significantly inhibited duodenal and jejunal motility and promoted distal colon motility. ICC deficiency in WsWs−/− rats led to a reduction in the promoting effect of LI11 on duodenal motility, a decrease in the promoting effect of ST37 on jejunal motility, and a significant reduction in the promoting effect of BL25 on distal colonic motility in those rats. Additionally, ICC absence significantly attenuated the inhibitory effect of ST25 on duodenal motility. MA at ST37 or ST25 did not change the content of phenol red in the feces in WsRC+/+ and WsWs−/− rats.Conclusion and InferencesOur results suggest that the absence of ICC impairs the bidirectional regulatory effect of MA on intestinal function. It reveals the important role of ICC in the treatment of intestinal dysfunction diseases by acupuncture and provides a new theoretical basis for the treatment of such diseases by MA.
Entrepreneurial Bricolage and Disruptive Innovation: The Joint Effect of Learning From Failure and Institutional voids
Authors: Yu Xiaoyu , Cao Gang , Wang Xinchun 
Published: December 2024

ABSTRACTDisruptive innovation is increasingly recognized as a strategy for small and medium‐sized enterprises (SMEs) to gain a competitive edge. However, SMEs often face resource constraints that create significant challenges to developing such innovation. Aiming to provide a potential solution for this problem, this study investigates how entrepreneurial bricolage can help SMEs overcome resource constraints to develop disruptive innovation in the context of emerging markets. Drawing on the resource orchestration perspective and using data from two waves of a survey involving 269 Chinese SMEs, the results indicate that entrepreneurial bricolage has a positive impact on disruptive innovation. Moreover, we find that failure‐based learning behaviors can strengthen the positive role of entrepreneurial bricolage in driving an SME's disruptive innovation, particularly when faced with high institutional voids. These findings provide compelling insights for SMEs in emerging markets seeking to gain competitive advantages through disruptive innovation.
The calcium sensor AtCML8 contributes to Arabidopsis plant cell growth by modulating the brassinosteroid signaling pathway
Authors: Lucchin Amandine , Fouassier Hélène , Robe Eugénie , Mbengue Malick , Aguilar Marielle , San Clemente Hélène , Vert Grégory , Galaud Jean‐Philippe , Aldon Didier 
Published: December 2024

SUMMARYCalcium signaling plays an essential role in integrating plant responses to diverse stimuli and regulating growth and development. While some signaling components and their roles are well‐established, such as the ubiquitous calmodulin (CaM) sensor, plants possess a broader repertoire of calcium sensors. Notably, CaM‐like proteins (CMLs) represent a poorly characterized class for which interacting partners and biological functions remain largely elusive. Our work investigates the role of Arabidopsis thaliana CML8 that exhibits a unique expression profile in seedlings. A reverse genetic approach revealed a function of CML8 in regulating root growth and hypocotyl elongation. RNA‐seq analyses highlighted CML8 association with the regulation of numerous genes involved in growth and brassinosteroid (BR) signaling. Using co‐immunoprecipitation experiments, we demonstrated that CML8 interacts with the BR receptor, BRI1, in planta in a ligand‐dependent manner. This finding suggests the existence of a novel regulatory step in the BR pathway, involving calcium signaling.
Diffuse iris melanoma leading to secondary glaucoma in a lion (Panthera leo)—A case report
Authors: Correa Jade Caproni , Moreira Matheus Vilardo Lóes , Javorouski Manoel Lucas , Werner Juliana , Shaw Gillian , Schreider Barbara , D'Otaviano de Castro Vilani Ricardo Guilherme , Montiani‐Ferreira Fabiano 
Published: December 2024

AbstractObjectiveTo describe the case of a 12‐year‐old male African lion (Panthera leo) presented with ocular discharge, corneal edema, and buphthalmos of the right eye.ProceduresOcular ultrasonography showed an intraocular mass involving the iris and ciliary body. Enucleation was performed.ResultsSubsequent histopathological analysis revealed a pleomorphic pigmented neoplastic cell population infiltrating, expanding and effacing the iris and ciliary body and occupying the ciliary cleft. The histopathological and immunohistochemical features were consistent with a diffuse iris melanoma (DIM).ConclusionDIM is the most common primary intraocular neoplasm of domestic cats, but rarely reported in large felids. The prognosis in large felids is unknown and warrants identifying additional cases and careful monitoring of affected individuals.
Investigation of Aqueous Ammonia/Hydrogen Blends for Use In Advanced Dual-Fuel Combustion
Authors: Tyrewala Daanish S. , Rothamer David , Ghandhi Jaal 
Published: December 2024

Abstract
Aqueous ammonia (NH4OH, a solution of 29.1% NH3 in water) and aqueous ammonia/hydrogen (NH4OH/H2) premixed blends were explored using a dual-fuel strategy with #2 diesel directly injected. Diesel fuel was substituted (at constant energy) with NH4OH and NH4OH/H2 blends at constant fuel energy while maintaining phasing using the diesel SOI timing. NH4OH/H2 blends were evaluated to investigate the efficacy of hydrogen for improving ignition quality and flame speed of the premixed mixture, and to determine if aqueous ammonia/hydrogen blends could be used as substitutes to represent the performance of anhydrous ammonia. The hydrogen concentration in the blends was adjusted to match adiabatic flame temperature (TAd) to anhydrous ammonia. Substitution of diesel fuel energy for aqueous ammonia was limited to 50% by energy at low-loads due to combustion instability, and challenges maintaining intake runner temperature at mid-loads due to significant enthalpy required to vaporize the aqueous ammonia. NH4OH/H2 blends exhibited improved combustion stability and led to over 4% decrease in unburned-to-supplied premixed energy, but were not suitable surrogates for NH3 combustion due to controlled end-gas autoignition (c-EGAI) and hydrogen preignition issues.
Effect of Blending Ammonia With Natural Gas Hydrocarbons on the Performance of a Heavy-Duty Spark Ignition Engine
Authors: Alvarez Luis F. , Askari Omid , Dumitrescu Cosmin E. 
Published: December 2024

Abstract
Ammonia (NH3) is a promising carbon-free fuel candidate to replace conventional petroleum-based fuels. However, when compared to conventional hydrocarbons, NH3 has poor combustion characteristics such as a low flame speed, a low calorific value, narrow flammability limits, and it requires a high ignition energy. As a result, the use of NH3 in practical power generation applications such as internal combustion engines may require a secondary fuel to promote and sustain the ammonia flame as well as hardware engine modifications such as a higher compression ratio, a high-energy ignition coil, etc. This work investigated the use of a dual-fuel approach involving NH3 and natural gas (NG) components (i.e., methane, propane, and ethane) in a single-cylinder four-stroke heavy-duty compression ignition engine converted to spark ignition, at an engine speed of 1000 RPM, equivalence ratio of 0.8, and an energy substitution ratio (ESR) of the hydrocarbon fuel up to 0.4. The goal was to identify ways to minimize engine modifications when ammonia is used. The results showed no penalty on efficiency when replacing the NG components with NH3, as the overall combustion phasing was more optimal as ESR increased. In addition, since all the IMEP values were significantly close to each other for different ST, no need for significant change in the engine control strategy was identified. The COVIMEP (coefficient of variance of indicated mean effective pressure) showed an increase with ESR, suggesting that the addition of NH3 to the mixture led to more cycle-to-cycle variations, with propane having the highest COVIMEP. This higher cycle-to-cycle variation for propane-ammonia mixtures was probably coming from a competition between its higher reactivity when compared to the other two hydrocarbons and the effect of different fuel properties on the in-cylinder gas motion.
Decanol/Biodiesel Blends for Full Diesel Fuel Replacement
Authors: Markov Krasimir , Stanchev Hristo 
Published: December 2024

Abstract
In the modern world, in the conditions of increasingly severe emission standards, increased oil prices and the political pressure to abandon internal combustion engines and implement electric vehicles, the search for alternative solutions for engines development is a key decision. One of these solutions currently accepted by European politicians is the use of biofuels. A highly promising fuel, which is at the very beginning of its research as an application in diesel engines, is the 1-decanol. Except for the higher viscosity and latent heat of vaporization, all its other properties are very similar to diesel fuel. One of the two ways to reduce viscosity is by blending it with another fuel, for which rapeseed biodiesel was chosen. The objective of the research is to investigate engine performance and emissions at different loads and engine speeds using decanol-biodiesel blends. Two types of blends were studied — Dec70B30 and Dec50B50. The study was conducted on a turbocharged diesel engine with common rail injection system. Compared to the diesel fuel, the results show a decrease in brake power up to 21.5%, increase in BSFC up to 19.96% at low and average loads and speeds, reduction of the CO2 emissions up to 23.33% while PM, HC and NOx emissions are variable in nature showing high increase or reduction depending the load, speed and used blend.
Canonical quantization of the U(1) gauge field in the right Rindler-wedge in the Rindler coordinates
Authors: Takeuchi Shingo 
Published: December 2024

Abstract
In this study, the canonical quantization of the U(1) gauge field in the Lorentz-covariant gauge in the right Rindler-wedge (RRW) of the four-dimensional Rindler coordinates is performed. Specifically, we obtain the gauge-fixed Lagrangian by the Lorentz-covariant gauge in the RRW of the Rindler coordinates, which is composed of the U(1) gauge field and B-field. Then, we obtain the mode-solutions of the U(1) gauge field and B-field by solving the equations of motion obtained from that gauge-fixed Lagrangian. Subsequently, defining the Klein–Gordon inner-product in the RRW of the Rindler coordinates, we determine the normalization constants of all directions of the mode-solutions of the U(1) gauge field and B-field. Then, for the U(1) gauge field given by those normalized mode-expanded solutions, we obtain the commutation relations of the creation and annihilation operators defined in the RRW of the Rindler coordinates by formulating the canonical commutation relations. In addition, we provide a polarization vector for the annihilation operators obtained in this way. Using these result, we show that the Minkowski ground state can be expressed as the outer-product of the left and right Rindler-wedges state on which those creation and annihilation operators act. Then, tracing out the left Rindler states of that Minkowski ground state, we obtain the density matrix of the U(1) gauge field in the RRW. From this, we show that the U(1) gauge field in a constant accelerated system will feel the Unruh temperature as well.
Computational reproducibility in computational social science
Authors: Schoch David , Chan Chung-hong , Wagner Claudia , Bleier Arnim 
Published: December 2024

AbstractOpen science practices have been widely discussed and have been implemented with varying success in different disciplines. We argue that computational-x disciplines such as computational social science, are also susceptible to the symptoms of the crises, but in terms of reproducibility. We expand the binary definition of reproducibility into a tier system which allows increasing levels of reproducibility based on external verifiability to counteract the practice of open-washing. We provide solutions for barriers in Computational Social Science that hinder researchers from obtaining the highest level of reproducibility, including the use of alternate data sources and considering reproducibility proactively.
The Significance of Paying Attention to Medical Emergencies in Medical Diagnostic Laboratories in Iran
Authors: Yousefi Mohammad Javad , Soltani Mansoor , Mezginejad Fatemeh , Yousefi Kosar , Takhviji Mahdi , Soltani Mohammad Hossein 
Published: December 2024

Background: Medical diagnostic laboratories as high‐risk environments are often exposed to unpredictable situations such as patient fainting, blood pressure drops, chemical spills, and burns. These life‐threatening events defined as medical emergencies and necessitate urgent actions. Hence, determining the most common medical emergencies in medical laboratories, so understanding and planning strategies to effective management seems to be crucial.Objective: This study aimed to investigate medical crises in Iranian medical laboratories.Methods: In this cross‐sectional study, data collection was performed by a simple random sampling method through electronic and paper questionnaires filled by personnel in private and hospital laboratories in different provinces.Results: The most frequent medical emergencies were patient fainting, staff needle stick, and patient’s blood pressure dropping. The occurrence of medical emergencies was 24% and 76% in men and women, respectively. Out of all, treatment was administered at the scene of the accident in 37.1% of cases, and 28.1% were discharged after sampling. Moreover, 51% of the medical diagnostic laboratories had a trolley code, with injection devices and angiocaths as available tools. In 81% of the laboratories, practicing for probable medical emergencies was not possible. A significant relationship was found between the type of client (laboratory personnel or the referring person) and the type of emergency event (p < 0.05).Conclusions: Considering the prevalence and importance of handling medical emergencies in a short time, it is necessary to design training courses for laboratory personnel and expert them to encountering with unpredictable threats in order to help affected individuals.
The Prostaglandin EP4 Antagonist Vorbipiprant Combined with PD-1 Blockade for Refractory Microsatellite-Stable Metastatic Colorectal Cancer: A Phase Ib/IIa Trial
Authors: Pietrantonio Filippo , Morano Federica , Niger Monica , Ghelardi Filippo , Chiodoni Claudia , Palazzo Michele , Nichetti Federico , Manca Paolo , Cristarella Eleonora , Doldi Valentina , Zaffaroni Nadia , Sabella Giovanna , Brambilla Nadia , Benincasa Elena , Giacovelli Giampaolo , Vitalini Cristina , Girolami Federica , Rovati Lucio C. 
Published: December 2024

Abstract

Purpose:
Novel combinations are required to overcome resistance to immune checkpoint inhibitors in proficient mismatch repair (pMMR) or microsatellite-stable (MSS) metastatic colorectal cancer (mCRC). We aimed to determine whether vorbipiprant, a prostaglandin E2 receptor EP4 subtype antagonist, can convert immune-resistant mCRC into a tumor responsive to anti–PD-1 inhibition.

Patients and Methods:
This phase Ib/IIa prospective, open-label, single-arm trial followed a 3 + 3 dose-escalation and dose-optimization design. A total of 28 patients with chemorefractory pMMR/MSS mCRC were given dose-escalated oral vorbipiprant (30, 90, or 180 mg twice daily), along with biweekly intravenous balstilimab (3 mg/kg), an anti–PD-1 antibody. The primary endpoints included safety and the disease control rate (DCR). Secondary endpoints were the overall response rate, duration of response, progression-free survival, and overall survival.

Results:
No dose-limiting toxicities were observed. Of the 28 patients, seven (25%) experienced serious adverse events, but only one was attributed to vorbipiprant and one to balstilimab. The trial achieved a DCR of 50% observed across the entire cohort. In the subgroup of patients with liver metastases (n = 12), the DCR was 25%. The overall response rate was 11%, with three patients showing a partial response (median duration of response, 7.4 months). The median progression-free survival was 2.6 months, and the median overall survival was 14.2 months. Translational exploratory analyses suggested that vorbipiprant may boost response to anti–PD-1 in patients with immunogenic tumors.

Conclusions:
The combination of vorbipiprant and a PD-1 inhibitor (balstilimab) yielded sufficient activity in refractory pMMR/MSS mCRC, which is worthy of confirmation in future clinical trials in biomarker-enriched populations.