bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broad and Coarse: Modelling Demography, Subsistence and Transportation in Roman England
Authors: Franconi Tyler , Green Chris 
Published: February 2019

AbstractThe English Landscape and Identities project (EngLaId), which ran from 2011 to 2016 (ERC grant number 269797), was designed to take a long-term perspective on English archaeology from the Middle Bronze Age (c. 1500 BCE) to the Domesday survey (1086 CE). It was a legacy data project that collated an immense number of records of English archaeology from a large number of different public and academic sources. Within this mountain of material, the Roman period (43 to 410/411 CE) stood out as being particularly fecund, accounting for 40% of the data (by record count) coming from only 15% of the total timespan of the project. This paper examines the ways in which the EngLaId project approached the modelling and analysis of its data for Roman England. We focus here on the three themes of demography, subsistence economy and transportation. Overall, EngLaId provides an interesting contrast to the possibilities and limitations of the other projects presented in this volume because of its large spatiotemporal scale and its (thus necessary) broad-brush approaches to data analysis and modelling. It is also this large spatiotemporal scale that helps situate the Roman period within a much longer span of history, making evident what was unique to this time period and what was constant across multiple periods.
The Economic Archaeology of Roman Economic Performance
Authors: Jongman Willem M. 
Published: February 2019

AbstractRecent years have witnessed a paradigm shift in the study of the Roman economy. Methodologically modern economic analysis is now far more acceptable than it once was, and archaeology has become the major source of empirical data for many questions. On the substantive side there is now a far clearer appreciation of the major changes that the Roman economy underwent, with substantial growth of population and aggregate production and even some improvements in standard of living, but followed by equally dramatic decline. This economic success was not limited to the imperial core, but also extended to the provinces.
The factor structure of a Polish language version of the hospital anxiety depression scale (HADS)
Authors: Nezlek John B. , Rusanowska Marzena , Holas Paweł , Krejtz Izabela 
Published: February 2019

AbstractThe Hospital Anxiety Depression Scale (HADS) is widely used as a screening measure for psychological distress. Nevertheless, there is disagreement among researchers about the extent to which the HADS provides separate measures of anxiety and depression or a single measure of affectively based distress, and the present study was designed to contribute to this discussion. Participants (n = 951) who were psychologically distressed, but not hospitalized, completed a Polish language version of the HADS. A confirmatory factor analysis of participants’ responses confirmed a model with two correlated factors with one cross-loaded item. The estimated correlation between the factors was .68. These results suggest that the Polish version of the HADS consists of two correlated measures of affectively focused distress, depression and anxiety. Nevertheless, analysts and practitioners need to be cautious and take into account the possibility that the discriminant validity of these two scales may be somewhat limited given the correlation between the subscales and the possible cross-loadings of items.
ITP, ISP, AND SCH
Authors: HACHTMAN SHERWOOD , SINAPOVA DIMA 
Published: February 2019

Abstract$ISP$ cannot hold at the first or second successor of a singular strong limit of countable cofinality; on the other hand, we force a failure of “strong ${\rm{SCH}}$” across a cardinal where $ITP$ holds. We also show that $ITP$ does not imply that there are stationary many internally unbounded models.
Effects of rehabilitation pruning and agroforestry on cacao tree development and yield in an older full-sun plantation
Authors: Riedel Judith , Kägi Nora , Armengot Laura , Schneider Monika 
Published: February 2019

AbstractOveraged full-sun cacao plantations and the need for sustainable production systems call for combining rehabilitation of plantations with the establishment of agroforestry. We tested the effect of drastic rehabilitation pruning of old cacao tree stock and the introduction of both high- and low-diversity agroforestry on survival, growth and yield of T. cacao in a commercial plantation in peninsular Malaysia over a period of 5 years. We further determined the incidence of pests and diseases of cacao pods and assessed the performance of the whole system for smallholder farmers, including yields of by-crops. Rehabilitation pruning negatively affected cacao tree development and short-term yield. No more effects of pruning on cacao yield were observed starting in the third year on in the monoculture and starting in the fourth year on in low-diversity agroforestry. We found similar cacao tree development and yield in the low-diversity agroforestry and a common practice monoculture, suggesting that the implementation of agroforestry is a commercially feasible strategy, due to additional income generated through timber production. Reduced cacao tree development and yield in the high-diversity agroforestry were compensated by additional harvests of cassava and banana compared to monoculture. Incidence of cocoa pod borer (Conopomorpha cramerella) was lower in the agroforestry systems, especially the high-diversity system, while the incidence of black pod disease (Phytophthora spp.) did not differ between agroforestry and monoculture. The findings highlight the potential of agroforestry to reconcile ecologically sustainable land use with natural, cost-effective pest management. While pruning needs to be done with timing and disease pressure in mind to minimize short-term yield losses, this measure proved to be a feasible strategy for establishing agroforestry on extant plantations.
Defending heaven's desirability
Authors: NEPTUNE CLINTON 
Published: February 2019

AbstractBernard Williams famously argued that immortality would lead to intolerable tedium. If his conclusion is true, then we ought not desire any sort of blissful-type afterlife (heaven) that precludes death. I reconstruct Williams's argument and examine three possible defeaters for his premises: the possibility of infinite activity kinds, the inability to prefer justifiably non-existence over the enduring of suffering, and the existence of inexhaustible pleasures such as the deepening love relationship between family, friends, and God, if God exists. I will show that further attempts to reboot Williams's argument also fail to rule out the desirability of heaven.
How Procurement Judges The Value of Medical Technologies: A Review of Healthcare Tenders
Authors: Miller Fiona A. , Lehoux Pascale , Peacock Stuart , Rac Valeria E. , Neukomm Jeff , Barg Carolyn , Bytautas Jessica P. , Krahn Murray 
Published: February 2019

AbstractObjectivesProcurement's important role in healthcare decision making has encouraged criticism and calls for greater collaboration with health technology assessment (HTA), and necessitates detailed analysis of how procurement approaches the decision task.MethodsWe reviewed tender documents that solicit medical technologies for patient care in Canada, focusing on request for proposal (RFP) tenders that assess quality and cost, supplemented by a census of all tender types. We extracted data to assess (i) use of group purchasing organizations (GPOs) as buyers, (ii) evaluation criteria and rubrics, and (iii) contract terms, as indicators of supplier type and market conditions.ResultsGPOs were dominant buyers for RFPs (54/97) and all tender types (120/226), and RFPs were the most common tender (92/226), with few price-only tenders (11/226). Evaluation criteria for quality were technical, including clinical or material specifications, as well as vendor experience and qualifications; “total cost” was frequently referenced (83/97), but inconsistently used. The most common (47/97) evaluative rubric was summed scores, or summed scores after excluding those below a mandatory minimum (22/97), with majority weight (64.1 percent, 62.9 percent) assigned to quality criteria. Where specified, expected contract lengths with successful suppliers were high (mean, 3.93 years; average renewal, 2.14 years), and most buyers (37/42) expected to award to a single supplier.ConclusionsProcurement's evaluative approach is distinctive. While aiming to go beyond price in the acquisition of most medical technologies, it adopts a narrow approach to assessing quality and costs, but also attends to factors little considered by HTA, suggesting opportunities for mutual lesson learning.
Understanding the nature of associations between family instability, unsupportive parenting, and children's externalizing symptoms
Authors: Coe Jesse L. , Davies Patrick T. , Hentges Rochelle F. , Sturge-Apple Melissa L. 
Published: February 2019

AbstractThis study examined the mediating role of maternal unsupportive parenting in explaining associations between family instability and children's externalizing symptoms during the transition to formal schooling in early childhood. Participants included 243 preschool children (M age = 4.60 years) and their parents. Findings from cross-lagged autoregressive models conducted with multimethod (survey and observations), multi-informant (parent, teacher, and observer), longitudinal (three annual waves of data collection) data indicated that experiences with heightened family instability predicted decreases in supportive parenting, which in turn predicted increases in children's externalizing symptoms. Analyses also revealed a bidirectional association between parenting and family instability over time, such that higher levels of instability predicted decreases in supportive parenting, which in turn predicted increases in family instability.
Hybrid procedure of right ventricle outflow tract stenting in small infants with pulmonary atresia and ventricular septal defect: early and mid-term results from a single centre
Authors: Bondanza Sara , Calevo Maria Grazia , Derchi Maria Elena , Santoro Francesco , Marasini Maurizio 
Published: February 2019

AbstractIntroductionPulmonary atresia, ventricular septal defect, major aorto-pulmonary collateral arteries, and pulmonary arteries hypoplasia are rare and complex congenital defects that require early interventions to relieve cyanosis and enhance the growth of native pulmonary arteries. The treatment of these patients is still controversial. Surgical techniques require cardiopulmonary bypass which is poorly tolerated by small infants. Percutaneous techniques such as radiofrequency perforation can be challenging. The hybrid technique consists of perventricular stenting of the right ventricle outflow tract through medial sternotomy, to restore native pulmonary flow.MethodsWe retrospectively reviewed the cardiovascular database of our centre in order to analyse our experience in hybrid procedure. We detected six patients who underwent hybrid first approach between November 2007 and December 2015. We report our early results and mid-term outcomes.ResultsMedian age at the procedure was 26 days, median weight was 3150 g, and median Nakata index was 52 mm2/m2. All procedures were successful except for one: this patient underwent a surgical shunt. No immediate and early deaths or major complications occurred and oxygen saturation levels increased in all the patients. Patients were followed up for a period of 12–103 months, and four of them underwent a procedure of unifocalisation at the mean age of 12.5 months.ConclusionsWe reported data from the largest series of patients who underwent this hybrid procedure. Our experience demonstrated encouraging results to expand the use of this approach to bridge high-risk patients with diminutive pulmonary arteries to a second step of surgical repair.
Food security of food recipients of a food pantry and soup kitchen
Authors: Mousa Tamara Y , Freeland-Graves Jeanne H 
Published: February 2019

AbstractObjectiveTo discern the impact of food donations provided by a food pantry and soup kitchen on food security.DesignIn this cross-sectional study, participants completed a demographic questionnaire, core food security module, FFQ and list of food donations. The FFQ was utilized to assess diet quality as estimated via the 2010 Healthy Eating Index.SettingClients were selected randomly from a food pantry and soup kitchen in Central Texas, USA.ParticipantsA total of 222 adults.ResultsApproximately 73 % of participants lacked food security. Compared with the food secure, the food insecure consisted of 61 % men, 42 % Caucasians, 56 % single and 67 % homeless. Also, of the food insecure, 60 % were soup kitchen clients and 64 % had an annual income <$US 1000 (P<0·01). The probability of food insecurity was reduced by ≥1·17-fold when the total dietary intake included the food donations, as these were rich in fruits, total vegetables and grains, dairy and protein foods (P<0·05).ConclusionsFood insecurity was quite prevalent in this sample of individuals who visited food pantries and soup kitchens. The addition of food donations improved the quality of the participants’ total diet and had a positive influence on food security. Thus, community organizations should financially support these food assistance agencies and strive to offer a variety of healthy and tasty foods in adequate quantities to provide optimum diet quality.
Decidual RANKL/RANK interaction promotes the residence and polarization of TGF-β1-producing regulatory γδ T cells
Authors: Chang Rui-Qi , Shao Jun , Meng Yu-Han , Wang Jian , Li Da-Jin , Li Ming-Qing 
Published: February 2019

AbstactDecidual γδΤ (dγδΤ) cells play an essential role during successful pregnancy; however, the residence and polarization of γδΤ cells in decidua remain unclear. In this study, we observed higher levels of receptor activator for nuclear factor-κ B ligand (RANKL) on decidual stromal cells (DSCs), and its receptor RANK on dγδΤ cells in decidua from normal pregnancy compared with patients with recurrent spontaneous abortion (RSA). RANKL expressed by DSCs can induce the polarization of peripheral blood γδΤ (pγδΤ) and dγδΤ cells to Foxp3 + γδΤ cells, and upregulate the expression of transforming growth factor (TGF)-β1. This process is mediated through activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). In addition, RANKL promotes the adhesion of dγδΤ cells to DSCs in vitro, which is associated with the upregulation of ICAM-1 and VCAM-1 on DSCs and integrins on dγδΤ cells. RANKL knockout leads to the decreased numbers of uterus total γδΤ cells, Foxp3+γδΤ cells and the expression of TGF-β1, and the increased pregnancy loss in mice. These results suggest that RANKL is a pivotal regulator of maternal-fetal tolerance by triggering the polarization and residence of TGF-β1-producing Foxp3+γδΤ cells in early pregnancy. The abnormal low level of RANKL/RANK results in pregnancy loss because of the dialogue disorder between DSCs and dγδΤ cells. This observation provides a scientific basis on which a potential marker can be detected to early warning of pregnancy loss.
The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer
Authors: Tang Weimei , Zhou Weijie , Xiang Li , Wu Xiaosheng , Zhang Pei , Wang Jing , Liu Guangnan , Zhang Wenjing , Peng Ying , Huang Xiaoting , Cai Jianqun , Bai Yang , Bai Lan , Zhu Wei , Gu Hongxiang , Xiong Jing , Ye Chen , Li Aimin , Liu Side , Wang Jide 
Published: February 2019

AbstractThe biological role of miR-500a-5p has not yet been reported in the context of colorectal cancer (CRC). Here, we show that miR-500a-5p expression is decreased in CRC tissues compared with adjacent normal tissues. Low miR-500a-5p expression is associated with malignant progression. Moreover, transfection of CRC cells with miR-500a-5p induces G0/G1 cell cycle arrest and inhibits their growth and migration. Mechanistically, miR-500a-5p directly targets HDAC2 and inhibits HDAC2-mediated proliferation in CRC in nude mice. Furthermore, YY1 binds to the promoter of miR-500a-5p and negatively regulates its transcription. Restoration of miR-500a-5p expression is up-regulated via the p300/YY1/HDAC2 complex. Besides, therapeutic delivery of miR-500a-5p significantly suppresses tumour development in a xenograft tumour model and a HDAC2 inhibitor FK228-treated CRC model. Our studies demonstrate that miR-500a-5p functions as a tumour suppressor in CRC by targeting the p300/YY1/HDAC2 axis, which contributes to the development of and provides new potential candidates for CRC therapy.
Fire-derived organic matter retains ammonia through covalent bond formation
Authors: Hestrin Rachel , Torres-Rojas Dorisel , Dynes James J. , Hook James M. , Regier Tom Z. , Gillespie Adam W. , Smernik Ronald J. , Lehmann Johannes 
Published: February 2019

AbstractFire-derived organic matter, often referred to as pyrogenic organic matter (PyOM), is present in the Earth’s soil, sediment, atmosphere, and water. We investigated interactions of PyOM with ammonia (NH3) gas, which makes up much of the Earth’s reactive nitrogen (N) pool. Here we show that PyOM’s NH3 retention capacity under ambient conditions can exceed 180 mg N g−1 PyOM–carbon, resulting in a material with a higher N content than any unprocessed plant material and most animal manures. As PyOM is weathered, NH3 retention increases sixfold, with more than half of the N retained through chemisorption rather than physisorption. Near-edge X-ray absorption fine structure and nuclear magnetic resonance spectroscopy reveal that a variety of covalent bonds form between NH3-N and PyOM, more than 10% of which contained heterocyclic structures. We estimate that through these mechanisms soil PyOM stocks could retain more than 600-fold annual NH3 emissions from agriculture, exerting an important control on global N cycling.
Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
Authors: Gräb Jessica , Suárez Isabelle , van Gumpel Edeltraud , Winter Sandra , Schreiber Fynn , Esser Anna , Hölscher Christoph , Fritsch Melanie , Herb Marc , Schramm Michael , Wachsmuth Laurens , Pallasch Christian , Pasparakis Manolis , Kashkar Hamid , Rybniker Jan 
Published: February 2019

AbstractCorticosteroids are host-directed drugs with proven beneficial effect on survival of tuberculosis (TB) patients, but their precise mechanisms of action in this disease remain largely unknown. Here we show that corticosteroids such as dexamethasone inhibit necrotic cell death of cells infected with Mycobacterium tuberculosis (Mtb) by facilitating mitogen-activated protein kinase phosphatase 1 (MKP-1)-dependent dephosphorylation of p38 MAPK. Characterization of infected mixed lineage kinase domain-like (MLKL) and tumor necrosis factor receptor 1 (TNFR1) knockout cells show that the underlying mechanism is independent from TNFα-signaling and necroptosis. Our results link corticosteroid function and p38 MAPK inhibition to abrogation of necrotic cell death mediated by mitochondrial membrane permeability transition, and open new avenues for research on novel host-directed therapies (HDT).
Population-wide analysis of differences in disease progression patterns in men and women
Authors: Westergaard David , Moseley Pope , Sørup Freja Karuna Hemmingsen , Baldi Pierre , Brunak Søren 
Published: February 2019

AbstractSex-stratified medicine is a fundamentally important, yet understudied, facet of modern medical care. A data-driven model for how to systematically analyze population-wide, longitudinal differences in hospital admissions between men and women is needed. Here, we demonstrate a systematic analysis of all diseases and disease co-occurrences in the complete Danish population using the ICD-10 and Global Burden of Disease terminologies. Incidence rates of single diagnoses are different for men and women in most cases. The age at first diagnosis is typically lower for men, compared to women. Men and women share many disease co-occurrences. However, many sex-associated incongruities not linked directly to anatomical or genomic differences are also found. Analysis of multi-step trajectories uncover differences in longitudinal patterns, for example concerning injuries and substance abuse, cancer, and osteoporosis. The results point towards the need for an increased focus on sex-stratified medicine to elucidate the origins of the socio-economic and ethological differences.
Ecosystem structural changes controlled by altered rainfall climatology in tropical savannas
Authors: Zhang Wenmin , Brandt Martin , Penuelas Josep , Guichard Françoise , Tong Xiaoye , Tian Feng , Fensholt Rasmus 
Published: February 2019

AbstractTropical savannas comprise mixed woodland grassland ecosystems in which trees and grasses compete for water resources thereby maintaining the spatial structuring of this ecosystem. A global change in rainfall climatology may impact the structure of tropical savanna ecosystems by favouring woody plants, relative to herbaceous vegetation. Here we analysed satellite data and observed a relatively higher increase in woody vegetation (5%) as compared to the increase in annual maximum leaf area index (LAImax, an indicator of the total green vegetation production) (3%) in arid and semi-arid savannas over recent decades. We further observed a declining sensitivity of LAImax to annual rainfall over 56% of the tropical savannas, spatially overlapping with areas of increased woody cover and altered rainfall climatology. This suggests a climate-induced shift in the coexistence of woody and herbaceous vegetation in savanna ecosystems, possibly caused by altered hydrological conditions with significance for land cover and associated biophysical effects such as surface albedo and evapotranspiration.
A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
Authors: Coelho João P. L. , Stahl Matthias , Bloemeke Nicolas , Meighen-Berger Kevin , Alvira Carlos Piedrafita , Zhang Zai-Rong , Sieber Stephan A. , Feige Matthias J. 
Published: February 2019

AbstractA fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined orientation of each transmembrane segment. Despite this, it remains unclear how cells detect and handle failures in this process. Here we show that single point mutations in the membrane protein connexin 32 (Cx32), which cause Charcot-Marie-Tooth disease, can cause failures in membrane integration. This leads to Cx32 transport defects and rapid degradation. Our data show that multiple chaperones detect and remedy this aberrant behavior: the ER–membrane complex (EMC) aids in membrane integration of low-hydrophobicity transmembrane segments. If they fail to integrate, these are recognized by the ER–lumenal chaperone BiP. Ultimately, the E3 ligase gp78 ubiquitinates Cx32 proteins, targeting them for degradation. Thus, cells use a coordinated system of chaperones for the complex task of membrane protein biogenesis, which can be compromised by single point mutations, causing human disease.