bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Li1.17Ni0.20Mn0.53Co0.10O2 as an Interesting Li‐ and Mn‐Rich Layered Oxide Cathode Material through Electrochemistry, Microscopy, and In Situ Electrochemical Dilatometry
Authors: Nayak Prasant Kumar , Yang Liangtao , Pollok Kilian , Langenhorst Falko , Aurbach Doron , Adelhelm Philipp 
Published: May 2019

AbstractDespite their high capacity, Li‐ and Mn‐rich layered oxide cathode materials suffer from capacity fading during prolonged cycling when cycled to potentials higher than 4.5 V vs. Li+/Li. In the work reported herein, we have synthesized the Li‐ and Mn‐rich Li1.17Ni0.20Mn0.53Co0.10O2 cathode material by using a sol‐gel method. The composition and structure are analyzed by ICP, XRD, SEM, and TEM. During testing in half‐cells between 2.5 and 4.6 V vs. Li+/Li at 20 mA g−1, the initial capacity of about 165 mAh g−1 increases during cycling, reaching about 200 mAh g−1 after 30 cycles. The capacity then slowly fades, reaching 188 mAh g−1 after 120 cycles. Also, a high average discharge potential of 3.8 V is obtained, which decreases to 3.6 V after 120 cycles. This study leads to new insights about the effect of Ni concentration on the stability of the Li‐ and Mn‐ rich cathode materials. The in situ electrochemical dilatometry (ECD) study demonstrates an irreversible process during the 1st cycle, which can be related to the activation of Li2MnO3. During subsequent cycles, the electrodes’ thickness does not change, which reflects a morphological stabilization, in contrast to the continuous electrochemical instability of these materials upon cycling.
Numerical study for estimation of temperature distribution in solar pond in diverse climatic conditions for all cities of Turkey
Authors: Sogukpinar Haci 
Published: May 2019

AbstractIn this study, a numerical investigation for the solar ponds temperature distribution in Turkey was conducted and is compared with the experimental data for a particular district. For this, a prototype salinity‐gradient solar pond with square cross‐section with insulated wall and with seven layers was modeled by considering previously conducted experimental studies, and then, numerical method was conducted by using Finite Element Method with a commercial software COMSOL. Temperature and solar radiation data were taken from General Directorate of Meteorology where they have been measured since 1927. Numerical calculation was performed by taking annual average values of temperature and solar radiation data. The model includes all possibility to calculate temperature distribution of upper convective zone, non‐convective zone, and the heat storage zone where radiative, conductive, and evaporative heat losses were taken into account. Numerical results indicate that during 720 hr of total simulation, maximum temperature was calculated at the end of 600 hr and then temperature remained constant. As the side wall and base were insulated with rock wool, a lot of heat loss was simulated at the top surface of the pond. According to the numerical study in 81 provinces, only one solar pond temperature remained under 300 K in Edirne and solar pond temperatures in five provinces remained under 310 K, and the solar pond temperature for 31 provinces were calculated higher than 320 K.
Modeling and optimization of chromium adsorption onto clay using response surface methodology, artificial neural network, and equilibrium isotherm models
Authors: Oskui Fatemeh Notghi , Aghdasinia Hassan , Sorkhabi Mahsa Golghasemi 
Published: May 2019

AbstractResponse surface methodology (RSM) was used for optimization of the adsorbent dosage, initial solution pH, initial ion concentration, and contact time in removal of Cr (III) with local nanoclay. The adsorption process was modeled by RSM and artificial neural network (ANN). The process was done in batch mode by central composite design (CCD) and the same design was applied for training ANN. The optimum condition was determined to be 500mg/L for adsorbent dosage, initial pH of 5, initial chromium concentration of 180mg/L and 20 min of contact time. In these conditions qRSM = 238.7780mg/g and qANN = 237.5152mg/g which indicate removal percentage of 72.45% and 72.07%, respectively. and indicate that the two models can predict the adsorption of Cr3+ properly. The two parameter Langmuir, Freundlich, Dubinin‐Radushkevich (D‐R), Temkin and three parameter Redlich‐Peterson (R‐PT), Sips and Toth isotherm models were applied to equilibrium data by minimizing the sum of squared errors (SSE), sum of the absolute errors (SAE), average relative errors (ARE), Hybrid fractional error function (HYBRID), Marquardt's percent standard deviation (MPSD), and nonlinear chi‐square test error functions. The results showed that the HYBRID error function gives the lowest value and the R‐PT model fits the data better than other isotherm models.
Comparative Analysis of Plant Demographic Traits Across Species of Different Conservation Concern: Implications for Pesticide Risk Assessment
Authors: Rueda-Cediel Pamela , Brain Richard , Galic Nika , Forbes Valery 
Published: May 2019

Abstract
Pesticide risk assessment for “listed” (threatened and endangered) plant species is hampered by a lack of quantitative demographic information. Demographic information for nonlisted plant species could provide risk-assessment data and inform recovery plans for listed species; however, it is unclear how representative demography of the former would be for the latter. We performed a comparison of plant demographic traits and elasticity metrics to explore how similar these are between listed and nonlisted species. We used transition matrices from the COMPADRE Plant Matrix Database to calculate population growth rate (λ), net reproductive rate (Ro), generation time (Tg), damping ratio (ρ), and summed elasticities for survival (stasis), growth, fertility (reproduction), and evenness of elasticity (EE). We compared these across species varying in conservation status and population trend. Phylogenetic generalized least squares (PGLS) models were used to evaluate differences between listed and nonlisted plants. Overall, demographic traits were largely overlapping for listed and nonlisted species. Population trends had a significant impact on most demographic traits and elasticity patterns. The influence of Tg on elasticity metrics was consistent across all data groupings. In contrast, the influence of λ on elasticity metrics was highly variable, and correlated in opposite directions in growing and declining populations. Our results suggested that population models developed for nonlisted plant species may be useful for assessing the risks of pesticides to listed species. Environ Toxicol Chem 2019;38:2043–2052. © 2019 SETAC.
A Proof‐of‐Concept Study on Scoring Oral Presentation Videos in Higher Education
Authors: Feng Gary , Joe Jilliam , Kitchen Christopher , Mao Liyang , Roohr Katrina Crotts , Chen Lei 
Published: May 2019

This proof‐of‐concept study examined the feasibility of a new scoring procedure designed to reduce the time of scoring a video‐based public speaking assessment task. Instead of scoring the video in its entirety, the performance was evaluated based on content‐related (e.g., speech organization, word choice) and delivery‐related (e.g., vocal expression, nonverbal behaviors) dimensions. Content‐related dimensions were scored based on speech transcripts, while delivery dimensions were scored using a video thin‐slicing technique, where scores were assigned based on brief vignettes of a video rather than the complete performance. Initial feasibility data were collected from 4 novice raters scoring 10 video performances. Results indicated that for delivery dimensions, four 10 second thin slices yielded interrater consistency reliability somewhat similar to that of full‐video scoring, and additional slices resulted in only small improvements. For transcription‐based scoring, while raters were consistent, their scores had low correlations with criterion scores, which was likely due to differences in the modality (video vs. text). Video thin‐slicing appears to be a promising scoring technique for relevant constructs. Further testing of a combination of audio and transcript is recommended for scoring content‐related constructs.
Secondary analysis of the WOMAN trial to explore the risk of sepsis after invasive treatments for postpartum hemorrhage
Authors: Cornelissen Laura , Woodd Susannah , Shakur‐Still Haleema , Fawole Bukola , Noor Shehla , Etuk Saturday , Akintan Adesina Lawrence , Chaudhri Rizwana , Roberts Ian 
Published: May 2019

AbstractObjectiveTo examine the association between the use of invasive treatments for postpartum hemorrhage and the risk of sepsis and severe sepsis.MethodsSecondary data analysis of the WOMAN randomized controlled trial, including 20 060 women with postpartum hemorrhage in 21 countries. Logistic regression with random effects was used.ResultsThe cumulative incidence was 1.8% for sepsis and 0.5% for severe sepsis. All‐cause mortality was 40.4% in women with severe sepsis versus 2.2% for women without. After adjusting for bleeding severity and other confounders, intrauterine tamponade, hysterectomy, and laparotomy increased the risk of sepsis (aOR 1.77 [95% CI 1.21–2.59], P=0.004; aOR 1.97 [95% CI 1.49–2.65], P<0.001; and aOR 6.63 [95% CI 4.29–10.24], P<0.001, respectively) and severe sepsis (aOR 2.60 [95% CI 1.47–4.59], P=0.002; aOR 1.97 [95% CI 0.83–2.46], P=0.033; and aOR 5.35 [95% CI 2.61–10.98], P<0.001, respectively).ConclusionIn this secondary data analysis, certain invasive treatments for postpartum hemorrhage appear to increase the risk of sepsis. Further research is needed to confirm this finding and investigate the role of prophylactic antibiotics during these procedures. The harms and benefits of such interventions must be carefully weighed, both in treatment guidelines and during individual patient management.Trial Registration: ISRCTN76912190
Hyaluronic acid hydrogel loaded by adipose stem cells enhances wound healing by modulating IL‐1β, TGF‐β1, and bFGF in burn wound model in rat
Authors: Alemzadeh Esmat , Oryan Ahmad , Mohammadi Ali A. 
Published: May 2019

AbstractApplication of hydrogels can be an effective technique in transferring the adipose‐derived stem cells (ASCs) to injured tissue and their protection from further complications. Besides, acellular dermal matrix (ADM) has successfully been used in treatment of wounds. In this study, a combination of hylauronic acid (HA) and ASCs (HA/ASCs) was applied on burn wounds and the injured area was then covered by an ADM dressing in a rat model (ADM‐HA/ASCs). Wound healing was evaluated by histopathological, histomorphometrical, molecular, biochemical, and scanning electron microscopy assessments on days 7, 14, and 28 post‐wounding. ADM‐HA/ASCs stimulated healing significantly more than the ADM‐HA and ADM treated wounds, as it led to reduced inflammation, and improved angiogenesis and enhanced granulation tissue formation. Expression of interleukin‐1β (IL‐1β) and transforming growth factor‐β1 (TGF‐β1) was lower in the ADM‐HA/ASCs treated wounds than the ADM‐HA and ADM groups, at the seventh post‐wounding day. ADM‐HA/ASCs also enhanced the expression level of TGF‐β1 mRNA at 14 day post‐wounding that was parallel to the experimental data from histological and biochemical assessments and confirmed the positive role of ASCs in repair of burn wounds. Additionally, increase in basic fibroblast growth factor (bFGF) expression and decreased TGF‐β1 level on the 28th post‐wounding day indicated the anti‐scarring activity of ASCs. HA loaded by adipose stem cells can represent a promising strategy in accelerating burn wound healing.
A 4‐gene panel predicting the survival of patients with glioblastoma
Authors: Guo Xiao‐Xia , Su Jiao , He Xiao‐Feng 
Published: May 2019

AbstractBackgroundTo identify independently prognostic gene panel in patients with glioblastoma (GBM).Materials and methodsThe Cancer Genome Atlas (TCGA)‐GBM was used as a training set and a test set. GSE13041 was used as a validation set. Survival associated differentially expression genes (DEGs), derived between GBM and normal brain tissue, was obtained using univariate Cox proportional hazards regression model and then was included in a least absolute shrinkage and selection operator penalized Cox proportional hazards regression model. Thus, a 4‐gene prognostic panel was developed based on the risk score for each patient in that model. The prognostic role of the 4‐gene panel was validated using univariate and multivariable Cox proportional hazards regression model.ResultsA total of 686 patients with GBM were included in our study; 724 DEGs was identified, 133 of which was significantly correlated with the overall survival (OS) of patients with GBM. A 4‐gene panel including NMB, RTN1, GPC5, and epithelial membrane protein 3 (EMP3) was developed. Kaplan‐Meier survival analysis suggested that patients in the 4‐gene panel low risk group had significantly better OS than those in the 4‐gene panel high risk group in the training set (hazard ratio [HR] = 0.3826; 95% confidence interval [CI]: 0.2751‐0.532; P < 0.0001), test set (HR = 0.718; 95% CI: 0.5282‐0.9759; P = 0.033) and the independent validation set (HR = 0.6898; 95% CI: 0.4872‐0.9766; P = 0.035). Both univariate and multivariable Cox proportional hazards regression analysis suggested that the 4‐gene panel was independent prognostic factor for GBM in the training set.ConclusionWe developed and validated 4‐gene panel that was independently correlated with the survival of patients with GBM.
Endocrinological characterization of pancreatic ducts in HFD and HGD fed mice
Authors: Huang Wenjun , Su Lianxiu , Zhang Xiaoxi , Xu Xiaoxiao , Li Rong 
Published: May 2019

AbstractOur previous findings show that insulin‐produced cells are found in human pancreatic ducts. However, the underlying molecular mechanism of transdifferentiation in pancreatic ductal cells is not yet totally uncovered. High‐fat diet (HFD) and high‐glucose diet (HGD) fed mice were subjected to the biochemical tests in sera. And the pancreatic samples were used for immunostaining and immunoblotting assays, respectively. These serological findings showed that fasting blood glucose, insulin, blood lipids (triglyceride, total cholesterol), liver functional enzymes (glutamic‐oxaloacetic transaminase, glutamic‐pyruvic transaminase) were increased in HFD fed mice. Immunostaining observations showed that insulin protein was positively expressed in pancreatic islets and ducts, characterized with elevated immunoreactive cells of insulin, neurogenin‐3, poly (ADP‐ribose) polymerase (PARP), and reduced F‐box/WD repeat‐containing protein 7‐positive cells in pancreatic islets and ducts of HFD and HGD fed mice. Interestingly, immunoblotting assays suggested that intrapancreatic expressions of insulin, Krüppel‐like Factor 2, PARP, p42/44MAPK proteins were upregulated in HFD and HGD exposed mice, while Fbxw7 protein content in pancreas samples were reduced. Taken together, the current findings reveal that there may be potential transdifferentiation of insulin‐producing cells in pancreatic ducts through inducing a pathway of intracellular Fbxw7 ubiquitination.
Lidocine potentiates the cytotoxicity of 5‐fluorouracil to choriocarcinoma cells by downregulating ABC transport proteins expression
Authors: Zhang Xue , Pang Wenwen , Liu Hong , Wang Juan 
Published: May 2019

AbstractChoriocarcinoma is a gestational trophoblastic cancer, which often occurs in the first 3 months of pregnancy. 5‐Fluorouracil (5‐Fu) is the widely used chemotherapeutic drug for choriocarcinoma but limited by drug resistance. Lidocaine, an aminamide‐type anesthetic, shows potential anticancer and chemosensitization effects in recent years. Herein, we tested the possible chemosensitization activity of lidocaine on the cytotoxicity of 5‐Fu in choriocarcinoma cells. Viabilities and apoptosis of choriocarcinoma JEG‐3 and JAR cells after lidocaine and/or 5‐Fu treatment were detected using Cell Counting Kit‐8 assay, annexin V‐FITC/PI (fluorescein isothiocyanate/propidium iodide) staining and Western blot analysis, respectively. Quantitative reverse transcription polymerase chain reaction was done to measure breast cancer resistance protein (ABCG2) messenger RNA level. Western blot analysis was carried out to detect ABCG2, P‐glycoprotein (P‐gp), MRP1, and MRP2 protein levels. pEX‐ABCG2 was transfected to elevate ABCG2 level. Then, the influence of ABCG2 on lidocaine + 5‐Fu‐caused cell viability loss, apoptosis, and inactivation of PI3K/AKT pathway were analyzed. We found that lidocaine in low concentration had no significant cytotoxicity to JEG‐3 and JAR cells, but stimulated cell apoptosis in high concentration. Moreover, lidocaine potentiated the cytotoxicity of 5‐Fu to JEG‐3 and JAR cells through decreasing viability and increasing apoptosis. Lidocaine treatment reduced the ABCG2, P‐gp, MRP1, and MRP2 protein levels in cells. Overexpression of ABCG2 reversed the synergistic effects of lidocaine + 5‐Fu on JEG‐3 and JAR cell viability and apoptosis, as well as PI3K/AKT pathway. Our research verified that lidocaine potentiated the cytotoxicity of 5‐Fu to choriocarcinoma cells by downregulating ATP‐binding cassette (ABC) transport proteins expression.
In limbo: A systematic review of psychological responses and coping among people with a missing loved one
Authors: Kennedy Cecilia , Deane Frank P. , Chan Amy Y. C. 
Published: May 2019

AbstractObjectiveThis review explored psychological responses and coping among loved ones left behind when a person is missing.MethodA systematic search identified 42 studies that reported data gathered among people with a missing loved one regarding psychological symptoms and/or coping strategies. Studies were arranged according to context of disappearance: forced (a result of war/conflict, abduction, forced separation) or unclear (reason unknown)/unspecified circumstances.ResultsThe most consistent findings for psychological symptoms were reports of depression, anxiety, posttraumatic stress, and prolonged grief reactions. When the disappearance was unclear/unspecified, people more often reported use of cognitive avoidance and continuing a bond as coping strategies. When the disappearance was forced, people more often reported use of informal support seeking.ConclusionsFurther research is warranted to clarify (a) the generalizability of findings to those left behind under circumstances where the ambiguity may be greater and (b) the acceptability of various targeted psychological interventions.
Knockdown of RAD18 inhibits glioblastoma development
Authors: Xie Chen , Lu Dejuan , Xu Meng , Qu Zhengyi , Zhang Weiguang , Wang Hongwei 
Published: May 2019

AbstractThis study aimed at investigating the role of RAD18 in the regulation of glioblastoma development as well as the underlying mechanisms. The human glioblastoma U251 and U87MG cells were transfected with siRNAs specifically targeting RAD18, and the effects of knockdown of RAD18 on the viability, apoptosis, migration, and invasion of U251 and U87MG cells were investigated. Transcriptome sequencing of the siRNA‐RAD18‐tranfected and siRNA‐NC‐transfected U251 cells was performed, followed by bioinformatic analyses for sequencing data. The results showed that knockdown of RAD18 significantly inhibited cell viability, promoted apoptosis, and suppressed migration and invasion of U251 and U87MG cells. Bioinformatic analyses of sequencing data identified 1,051 differentially expressed genes (DEGs) (369 up‐ and 682 downregulated genes) in the siRNA‐RAD18‐transfected U251 cells compared with siRNA‐NC‐transfected U251 cells. Eleven DEGs, including nerve growth factor (NGF), colony‐stimulating factor 2 (CSF2), matrix metallopeptidase 1 (MMP1), platelet‐derived growth factor receptor α (PDGFRA), and heme oxygenase 1 (HMOX1), were identified as the hub nodes in protein–protein interaction (PPI) network. Moreover, the aforementioned 11 hub genes were significantly enriched in PI3K–Akt signaling pathway and GO functions associated with the extracellular region. Notably, quantitative real‐time polymerase chain reaction further confirmed that the expression levels of NGF, CSF2, HMOX1, and MMP1 were significantly downregulated, while that of PDGFRA was markedly upregulated in the siRNA‐RAD18‐transfected U251 cells than in the siRNA‐NC cells. In conclusion, the knockdown of RAD18 may inhibit glioblastoma development by regulating the expression of the aforementioned key DEGs.
Proposal for a chemically consistent way to annotate ions arising from the analysis of reference compounds under ESI conditions: A prerequisite to proper mass spectral database constitution in metabolomics
Authors: Damont Annelaure , Olivier Marie‐Françoise , Warnet Anna , Lyan Bernard , Pujos‐Guillot Estelle , Jamin Emilien L. , Debrauwer Laurent , Bernillon Stéphane , Junot Christophe , Tabet Jean‐Claude , Fenaille François 
Published: May 2019

AbstractNowadays, high‐resolution mass spectrometry is widely used for metabolomic studies. Thanks to its high sensitivity, it enables the detection of a large range of metabolites. In metabolomics, the continuous quest for a metabolite identification as complete and accurate as possible has led during the last decade to an ever increasing development of public MS databases (including LC‐MS data) concomitantly with bioinformatic tool expansion. To facilitate the annotation process of MS profiles obtained from biological samples, but also to ease data sharing, exchange, and exploitation, the standardization and harmonization of the way to describe and annotate mass spectra seemed crucial to us. Indeed, under electrospray (ESI) conditions, a single metabolite does not produce a unique ion corresponding to its protonated or deprotonated form but could lead to a complex mixture of signals. These MS signals result from the existence of different natural isotopologues of the same compound and also to the potential formation of adduct ions, homomultimeric and heteromultimeric ions, fragment ions resulting from “prompt” in‐source dissociations. As a joint reflection process within the French Infrastructure for Metabolomics and Fluxomics (MetaboHUB) and with the purpose of developing a robust and exchangeable annotated MS database made from pure reference compounds (chemical standards) analysis, it appeared to us that giving the metabolomics community some clues to standardize and unambiguously annotate each MS feature was a prerequisite to data entry and further efficient querying of the mass spectral database. The use of a harmonized notation is also mandatory for interlaboratory MS data exchange. Additionally, thorough description of the variety of MS signals arising from the analysis of a unique metabolite might provide greater confidence on its annotation.
Abscopal effect when combining oncolytic adenovirus and checkpoint inhibitor in a humanized NOG mouse model of melanoma
Authors: Kuryk Lukasz , Møller Anne‐Sophie W. , Jaderberg Magnus 
Published: May 2019

AbstractMelanoma, an immunogenic tumor, is the first indication where oncolytic viruses are now becoming part of clinical practice. ONCOS‐102, a transgened adenovirus, has shown to act as a primer of relevant tumor targeting immune cells both in preclinical and clinical melanoma studies. Strategies to augment its effectiveness warrant investigation. Combination therapy of ONCOS‐102 with the checkpoint inhibitor (CPI) pembrolizumab was evaluated in a quasi‐human animal model, the humanized NOG mouse model. A dosing schedule of the combination, beginning the CPI concurrently with the oncolytic viral therapy and continuing the CPI treatment, appeared to induce an abscopal effect in untreated tumor lesions. Concurrent combination therapy with checkpoint inhibitors may improve the induction of antitumor immune responses of ONCOS‐102.