bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust controller design for uncertain delayed systems and its applications to hypersonic vehicles
Authors: Liu Hao , Zhang Jiansong , Xi Jianxiang , Yu Yao 
Published: January 2019

AbstractThe longitudinal dynamics of hypersonic flight vehicles involves strong nonlinearity and coupling, uncertainties including parametric uncertainties, unmodeled uncertainties, external disturbances, and time‐varying input and state time delays. In this paper, a robust controller design method is proposed for the longitudinal stabilization of these vehicles by the signal‐compensation‐based control idea. Theoretical analysis is given to prove the robustness properties of the designed closed‐loop control system subject to multiple time‐varying uncertainties and time‐varying input and state delays. Simulation results are performed to show the validness and advantages of the proposed robust control approach.
Prediction of early response to overall treatment for schizophrenia: A functional magnetic resonance imaging study
Authors: Cui Long‐Biao , Cai Min , Wang Xing‐Rui , Zhu Yuan‐Qiang , Wang Liu‐Xian , Xi Yi‐Bin , Wang Hua‐Ning , Zhu Xia , Yin Hong 
Published: January 2019

AbstractIntroductionTreatment response at an early stage of schizophrenia is of considerable value with regard to future management of the disorder; however, there are currently no biomarkers that can inform physicians about the likelihood of response.ObjectsWe aim to develop and validate regional brain activity derived from functional magnetic resonance imaging (fMRI) as a potential signature to predict early treatment response in schizophrenia.MethodsAmplitude of low‐frequency fluctuation (ALFF) was measured at the start of the first/single episode resulting in hospitalization. Inpatients were included in a principal dataset (n = 79) and a replication dataset (n = 44). Two groups of healthy controls (n = 87; n = 106) were also recruited for each dataset. The clinical response was assessed at discharge from the hospital. The predictive capacity of normalized ALFF in patients by healthy controls, ALFFratio, was evaluated based on diagnostic tests and clinical correlates.ResultsIn the principal dataset, responders exhibited increased baseline ALFF in the left postcentral gyrus/inferior parietal lobule relative to non‐responders. ALFFratio of responders before treatment was significantly higher than that of non‐responders (p < 0.001). The area under the receiver operating characteristic curve was 0.746 for baseline ALFFratio to distinguish responders from non‐responders, and the sensitivity, specificity, and accuracy were 72.7%, 68.6%, and 70.9%, respectively. Similar results were found in the independent replication dataset.ConclusionsBaseline regional activity of the brain seems to be predictive of early response to treatment for schizophrenia. This study shows that psycho‐neuroimaging holds promise for influencing the clinical treatment and management of schizophrenia.
Targeting of the HER2/HER3 signaling axis overcomes ligand‐mediated resistance to trastuzumab in HER2‐positive breast cancer
Authors: Watanabe Satomi , Yonesaka Kimio , Tanizaki Junko , Nonagase Yoshikane , Takegawa Naoki , Haratani Koji , Kawakami Hisato , Hayashi Hidetoshi , Takeda Masayuki , Tsurutani Junji , Nakagawa Kazuhiko 
Published: January 2019

AbstractHER2‐targeted therapy, especially the anti‐HER2 antibody trastuzumab, is standard for HER2‐positive breast cancer; however, its efficacy is limited in a subpopulation of patients. HER3 ligand (heregulin)‐dependent HER2‐HER3 interactions play a critical role in the evasion of apoptosis and are therefore a target for oncotherapy to treat HER2‐positive breast cancer. The anti‐HER2 antibody pertuzumab and anti‐HER3 antibody patritumab both target this heregulin–HER3‐HER2 complex in different ways. This study examined the anticancer efficacy of dual HER2 and HER3 blockade in trastuzumab‐resistant HER2‐positive breast cancer. HER2‐positive SKBR3 or BT474 cells overexpressing heregulin (SKBR3‐HRG, BT474‐HRG) were used to evaluate the efficacy of trastuzumab, pertuzumab, and patritumab in vitro by performing cell viability, immunoblotting, and clonogenic assays. The effects of these agents were then evaluated in vivo using BT474‐HRG and an intrinsic heregulin‐expressing and HER2‐positive JIMT‐1 xenograft models. SKBR3‐HRG and BT474‐HRG cells lost sensitivity to trastuzumab, which was accompanied by Akt activation. Unexpectedly, trastuzumab in combination with pertuzumab or patritumab also showed limited efficacy toward these cells. In contrast, trastuzumab/pertuzumab/patritumab triple treatment demonstrated potent anticancer efficacy, concomitant with strong repression of Akt. Finally, in heregulin‐expressing BT474‐HRG and JIMT‐1 xenograft models, the addition of pertuzumab and patritumab to trastuzumab also enhanced antitumor efficacy leading to tumor regression. The current study found that triple blockade of HER2 and HER3 using trastuzumab, pertuzumab, and patritumab could overcome resistance to trastuzumab therapy in heregulin‐expressing and HER2‐positive breast cancer, which could be exploited clinically.
KnowVolution of a Fungal Laccase toward Alkaline pH
Authors: Novoa Catalina , Dhoke Gaurao V. , Mate Diana M. , Martínez Ronny , Haarmann Thomas , Schreiter Martina , Eidner Jasmin , Schwerdtfeger Ruth , Lorenz Patrick , Davari Mehdi D. , Jakob Felix , Schwaneberg Ulrich 
Published: January 2019

AbstractTo date, commercial laccase preparations are used in the food, textile, and paper and pulp industries (mild pH). Laccases are attractive in the synthesis of dye molecules or oxidative lignin treatment, which take place at high pH (≥8.0). So far, one fungal laccase has been reported to be active at alkaline pH. Herein, engineering of the fungal laccase from Melanocarpus albomyces (MaL) for increased activity toward the substrate 2,6‐dimethoxyphenol at pH (≥9.0) is reported. Through a knowledge‐gaining directed evolution (KnowVolution) campaign, the key positions Leu365 and Leu513 were identified to increase alkaline tolerance. Both positions are located in close proximity of the T1Cu site. Molecular docking and simulations studies reveal that both substitutions act in a synergic way to stabilize and improve laccase activity at higher pH. Kinetic characterization of the final variant MaL‐M1 (L365E/L513M) revealed at pH 9.8 a threefold improved kcat (kcat=(6.0±0.2) s−1) compared with that of wild‐type M. albomyces laccase (kcat=(2.11±0.07) s−1).
Hulled varieties of Barley showed better expansion characteristics compared to hull‐less varieties during twin‐screw extrusion
Authors: Baidoo Elvis Alfred , Murphy Kevin , Ganjyal Girish M. 
Published: January 2019

AbstractBackground and objectivesConsumption of food barley is increasing due to its health and nutritional benefits. Whole grain flours of two hulled barley varieties, Lyon and Muir, and three hull‐less barley varieties, Havener, 09WA‐265.12, and Meg's Song, were extruded with a co‐rotating twin‐screw extruder. The impacts of feed moisture, screw speed, and die temperature on functional properties of extrudates were investigated.FindingsExpansion ratio (ER) of barleys was slightly lower compared to the reported numbers for cereals such as corn. Hulled varieties showed significantly higher ER compared to the hull‐less varieties. Havener was the only hull‐less variety having comparable ER with hulled varieties and moderate levels of ß‐glucan. ER correlated positively with water solubility index (r = 0.680, p < 0.01), specific mechanical energy (r = 0.633, p < 0.01), and negatively with unit density (r = −0.729, p < 0.01).ConclusionsHulled varieties are better suited for extrusion expansion. Feed moisture and die temperature had a strong influence on expansion, while screw speed showed marginal effects.Significance and noveltyUnderstanding the properties of hulled and hull‐less barley extrudates will enable process industry to utilize them for the development of novel extruded foods, while taking advantage of their nutritional values.
Chromatographic approach to study the configurational stability of Ni(II) complexes of amino‐acid Schiff bases possessing stereogenic nitrogen
Authors: Han Jianlin , Jean Marion , Roussel Christian , Moriwaki Hiroki , Soloshonok Vadim A. 
Published: January 2019

AbstractHerein, we disclose the design of a model Ni(II) complex of glycine Schiff base possessing single‐nitrogen stereogenic center, which was successfully used for high‐performance liquid chromatography (HPLC)‐assisted assessment of its configurational stability. The major finding is that the configurational stability of the Ni(II)‐coordinated nitrogen is profoundly dependent on the reaction conditions used, in particular the solvent, and can range from inconsequential (t½ less than 5 min) to virtually completely stable (t½ 90 y). The discovery reported in this study most likely to be of certain theoretical and synthetic value.
Technologien zur Speicherung von Wasserstoff. Teil 2: Irreversible Konversion und Technologievergleich
Authors: Müller Karsten 
Published: January 2019

AbstractWasserstoffspeicherung ist an sich erst einmal die Speicherung eines chemischen Stoffes. Sie wird aber sehr oft als Energiespeicherung verstanden. Angesichts der Tatsache, dass viele Technologien zur Wasserstoffspeicherung auf einer chemischen Konversion beruhen, stellt sich die Frage, ob bei einer energetischen Nutzung eine Rückkonversion zwingend erforderlich ist. Wird Wasserstoff beispielsweise durch eine chemische Reaktion in einen Kohlenwasserstoff überführt, so lässt sich dieser direkt verbrennen. Entsprechende Prozesse eröffnen neue Routen in der Nutzung von Wasserstoffenergie. Die entsprechenden Technologien werden vorgestellt und in einem umfassenderen Vergleich Speicheroptionen mit Rückgewinnung des Wasserstoffs gegenübergestellt.
Hydrogen peroxide‐assisted photocatalysis under solar light irradiation: Interpretation of interaction effects between an active photocatalyst and H2O2
Authors: Feilizadeh Mehrzad , Attar Farid , Mahinpey Nader 
Published: January 2019

AbstractIn this work, the combination of H2O2 and an active visible‐light‐driven photocatalyst (Ag‐S/PEG/TiO2) was utilized under natural solar radiation for the degradation of 2‐nitrophenol (2‐NP), and interaction effects between the photocatalyst and hydrogen peroxide were analyzed. For this purpose, experiments were designed using the response surface methodology based on the central composite design. The resulting data was utilized to obtain a model for the prediction of response (the degradation efficiency) as a function of two independent factors (H2O2 concentration and the photocatalyst loading). The statistical analysis indicated that optimum values of each of the two independent factors decreased by increasing the other one and vice versa. Moreover, it was found that adding the optimal amount of H2O2 to the solution, which contained just the photocatalyst, can enhance the degradation significantly (up to 45 %). However, using higher concentrations of H2O2 may decrease the efficiency. The global optimum condition was found to be 545 ppm and 316 mM for Ag‐S/PEG/TiO2 loading and H2O2 concentration, respectively. In this condition, the degradation efficiency of 2‐NP reached 92.4 % after only 45 min of solar light irradiation.
Photoinactivation of Planktonic and Biofilm Forms of Escherichia coli through the Action of Cationic Zinc(II) Phthalocyanines
Authors: Lourenço Leandro M. O. , Rocha Deisy M. G. C. , Ramos Catarina I. V. , Gomes Maria C. , Almeida Adelaide , Faustino Maria A. F. , Almeida Paz Filipe A. , Neves Maria G. P. M. S. , Cunha Ângela , Tomé João P. C. 
Published: January 2019

AbstractNovel water‐soluble zinc(II) phthalocyanines (ZnPc) peripherally substituted with 4‐dimethylaminopyridine (DMAP) units (ZnPc 1–2) and the corresponding quaternized derivatives (ZnPc 1 a–2 a) were synthesized and their photodynamic inactivation (PDI) efficiency against a Gram‐negative bacterium, a recombinant bioluminescent Escherichia coli strain either in planktonic or biofilm form, was investigated. The analysis of the photophysical properties revealed that the increase in the number of DMAP units on ZnPc shifted the absorption and emission band in aqueous media to the red region. The presence of multi‐positive charges on ZnPc derivatives prevented aggregation and enhances the solubility in aqueous media. The quaternized derivatives ZnPc 1 a and 2 a displayed good stability and promising efficacy to generate singlet oxygen (1O2). The affinity of the amphiphilic ZnPc 1–2 and quaternized ZnPc 1 a–2 a to planktonic bacterial cells corresponded to an average uptake of ∼106 PS molecules.CFU−1. The PDI assays conducted with planktonic cells and biofilms of E. coli show that irradiation with red or white light (150 mW.cm−2) in the presence of 20 μM of ZnPc derivatives caused an effective inactivation. ZnPc 1 a and ZnPc 2 a exhibited the highest inactivation efficiency, particularly of the planktonic form, causing a 5 log‐scale (99.99 %) reduction in bioluminescence. The inactivation factor for biofilms was 99 % (2 log). ZnPc 1 a and ZnPc 2 a can be regarded as promising photosensitizers for the photodynamic inactivation of Gram‐negative bacteria.
Traumatic dental injuries in preschool‐age children: Prevalence and risk factors
Authors: Born Catherine D. , Jackson Tate H. , Koroluk Lorne D. , Divaris Kimon 
Published: January 2019

AbstractThis study examined the prevalence, socio‐demographic correlates, and clinical predictors of traumatic dental injuries (TDIs) in the primary dentition among a community‐based sample of preschool‐age children. The sample comprised 1,546 preschool‐age children (mean age 49 [range: 24–71] months) in North Carolina public preschools, enrolled in a population‐based investigation among young children and their parents in North Carolina. Information on socio‐demographic, extraoral, and intraoral characteristics was collected and analyzed with bivariate and multivariate methods, including logistic regression modeling and marginal effects estimation. The prevalence of dental trauma was 47% and 8% of TDI cases were “severe” (pulp exposure, tooth displacement, discolored or necrotic tooth, or tooth loss). In bivariate analyses, overjet and lip incompetence were significantly associated with TDI. Overjet remained positively associated with severe trauma in multivariate analysis, OR = 1.4, 95% confidence interval (CI) [1.2, 1.6], corresponding to an absolute 1.3%, 95% CI [0.7, 1.8], increase in the likelihood of severe trauma, per millimeter of overjet. Children with increased overjet (>3 mm) were 3.8, 95% CI [2.0, 7.4], times as likely to have experienced severe TDI compared with those with ≤3 mm. Overjet is a strong risk factor for TDIs in the primary dentition. Incorporating and operationalizing this information may help TDI prevention and related anticipatory guidance for families of preschool‐age children.
Eumelanin levels in rufous feathers explain plasma testosterone levels and survival in swallows
Authors: Arai Emi , Hasegawa Masaru , Sato Megumi , Sakai Hidetsugu , Ito Shosuke , Wakamatsu Kazumasa 
Published: January 2019

AbstractPigment‐based plumage coloration and its physiological properties have attracted many researchers to explain the evolution of such ornamental traits. These studies, however, assume the functional importance of the predominant pigment while ignoring that of other minor pigments, and few studies have focused on the composition of these pigments. Using the pheomelanin‐based plumage in two swallow species, we studied the allocation of two pigments (the predominant pigment, pheomelanin, and the minor pigment, eumelanin) in relation to physiological properties and viability in populations under a natural and sexual selection. This is indispensable for studying the evolution of pheomelanin‐based plumage coloration. Pheomelanin and eumelanin share the same pathway only during their initial stages of development, which can be a key to unravel the functional importance of pigment allocation and thus of plumage coloration. Using the barn swallow,Hirundo rustica, a migratory species, we found that plasma testosterone levels increased with increasing the proportion of eumelanin pigments compared with pheomelanin pigments, but not with the amount of pheomelanin pigments, during the mating period. In the Pacific swallowHirundo tahitica, a nonmigratory congener, we found that, during severe winter weathers, survivors had a proportionally smaller amount of eumelanin pigments compared with pheomelanin pigments than that in nonsurvivors, but no detectable difference was found in the pheomelanin pigmentation itself. These results indicated that a minor pigment, eumelanin, matters at least in some physiological measures and viability. Because the major pigment, pheomelanin, has its own physiological properties, a combination of major and minor pigments provides multiple information to the signal receivers, potentially enhancing the signaling function of pheomelanic coloration and its diversification across habitats.
Delivery practices and care experience during implementation of an adapted safe childbirth checklist and respectful care program in Chiapas, Mexico
Authors: Molina Rose L. , Villar Jimena , Reyes Andrea , Elliott James , Begley Mark , Johnson Mike , Palazuelos Lindsay , Montaño Mariana , Flores Hugo , Semrau Katherine E.A. , Palazuelos Daniel 
Published: January 2019

AbstractObjectiveTo evaluate changes in quality of care after implementing an adapted safe childbirth checklist (SCC) in Chiapas, Mexico.MethodsA convergent mixed‐methods study was conducted among 447 women in labor who attended a rural community hospital between September 1, 2016, and June 30, 2017. Logistic regression analysis was used to evaluate adherence to evidence‐based practices over time, adjusting for provider. Participants were surveyed about their perceptions of care after hospital discharge. A purposefully sampled subgroup also completed in‐depth interviews. Thematic analysis was performed to evaluate perceptions of care.Results384 (85.9%) women were attended by staff that used the adapted SCC during delivery. Of these, 221 and 28 completed the hospital discharge survey and in‐depth interview, respectively. Adherence with offering a birth companion (odds ratio [OR] 3.06, 95% CI 1.40–6.68), free choice of birth position (2.75, 1.21–6.26), and immediate skin‐to‐skin contact (4.53, 1.97–10.39) improved 6–8 months after implementation. Participants’ perceived quality of care improved over time. Provider communication generated positive perceptions. Reprimanding women for arriving in early labor or complaining of pain generated negative perceptions.ConclusionUse of the adapted SCC improved quality of care through increased adherence with essential and respectful delivery practices.
Clinical significance of serum adiponectin and visfatin levels in endometrial cancer
Authors: Wang Zhongmin , Gao Shan , Sun Caixia , Li Jinyan , Gao Wenhui , Yu Liping 
Published: January 2019

AbstractObjectiveTo investigate serum adiponectin and visfatin levels, and their ratio, in patients with endometrial cancer.MethodsA retrospective case–control study of 53 patients with endometrial cancer admitted to Dalian Municipal Women and Children's Medical Center, China, between May 1, 2009, and January 31, 2013. Ninety‐eight healthy women who underwent physical examination at the same time served as the control group. Serum adiponectin and visfatin levels were measured by ELISA.ResultsSerum adiponectin level in the endometrial cancer group was significantly lower than in the control group (2.09 ± 1.24 μg/mL vs 7.59 ± 2.29 μg/mL; P<0.001). Serum adiponectin was positively correlated with visfatin level (Spearman correlation coefficient 0.472). The visfatin:adiponectin ratio in the endometrial cancer group was significantly higher than the control group (0.28 ± 0.10 vs 0.11 ± 0.09; P=0.047). Multivariate logistic regression showed that decreased serum adiponectin (odds ratio 0.998, 95% CI 0.996–0.999; P=0.045) and increased visfatin (1.010, 1.003–1.017; P=0.042) levels were independent risk factors for the onset of endometrial cancer.ConclusionDecreased serum adiponectin or increased visfatin levels are independent risk factors for endometrial cancer. The visfatin:adiponectin ratio has a certain reference value for the diagnosis of endometrial cancer.
Implementation of pharmacist‐managed anticoagulation in patients with continuous flow left ventricular assist devices
Authors: Bowman Stephanie , Weeks Phillip , Chow Elaine , Huang Athena , Nathan Sriram , Radovancevic Rajko , Kar Biswajit , Gregoric Igor 
Published: January 2019

BackgroundPatients with left ventricular assist devices (LVADs) are at high risk for bleeding and thrombotic events and may benefit from intensified anticoagulation management via a pharmacist‐managed anticoagulation service.AimsThe aim of this quality improvement project was to implement and assess anticoagulation management by a pharmacist‐managed warfarin anticoagulation service in LVAD patients.Materials and MethodsThis was a pilot study to assess the outcomes of anticoagulation management by a pharmacist‐managed outpatient anticoagulation service for the first 3 months following hospital discharge of patients with a newly implanted LVAD compared with a historical control group of LVAD patients managed by the previous standard‐of‐care. Time in therapeutic range and percent of international normalized ratio (INR) values within range were assessed as measures of anticoagulation. Twenty‐six patients were in the intervention group and an equal number of controls were included for analysis.ResultsPatients in the pharmacist‐managed intervention group experienced a significantly greater INR time in therapeutic range than the control group (66% vs 46.9%; P = 0.003) and a greater percentage of INRs within therapeutic range (62.6% vs 43.8%; P = 0.002).Discussion and ConclusionPharmacist‐managed anticoagulation was associated with improved INR control in this pilot group of LVAD patients in the first 3 months posthospital discharge. Additional study is warranted to determine if this benefit continues beyond 3 months, and to further assess clinical outcomes of thrombosis and bleeding events between groups.
Effect of magnesium on reducing the UV‐induced oxidative damage in marrow mesenchymal stem cells
Authors: Chen Yangmei , Xiong Shibing , Zhao Fenghua , Lu Xugang , Wu Boyao , Yang Bangcheng 
Published: January 2019

AbstractOxidative stress could cause damage to lipids, proteins and DNA, which is induced by the imbalance between the production of reactive oxygen species (ROS) and the biological system ability to counteract or detoxify their harmful effects. The oxidative stress damage significantly contributes to a number of diseases. Magnesium (Mg) is endowed with a novel function of removing excess ROS by releasing H2 during the degradation. In this study, in order to explore the property of anti‐oxidative damage of Mg metal, rat bone marrow mesenchymal stem cells (MSCs) oxidative damaged by ultraviolet (UV) radiation was employed to co‐culture with Mg metal. The effect of Mg metal on the response of antioxidant enzymes and mitochondria in MSCs was studied. We found that Mg metal could reduce the cellular oxidative stress damage and elevate the activities of antioxidant enzymes to maintain redox homeostasis. In addition, Mg metal could reduce the risk of UV‐induced cell apoptosis by increasing the ratio of Bcl‐2/Bax, elevating the mitochondrial membrane potential and blocking the release of cytochrome c. This finding showed Mg metal might have the potential for treating diseases caused by oxidative stress damage. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1253–1263, 2019.