bluuebunny/crossref_metadata_2025_split huggingface dataset:
Super‐resolution Imaging of Amyloid Structures over Extended Times by Using Transient Binding of Single Thioflavin T Molecules
Authors: Spehar Kevin , Ding Tianben , Sun Yuanzi , Kedia Niraja , Lu Jin , Nahass George R. , Lew Matthew D. , Bieschke Jan 
Published: June 2018

AbstractOligomeric amyloid structures are crucial therapeutic targets in Alzheimer's and other amyloid diseases. However, these oligomers are too small to be resolved by standard light microscopy. We have developed a simple and versatile tool to image amyloid structures by using thioflavin T without the need for covalent labeling or immunostaining. The dynamic binding of single dye molecules generates photon bursts that are used for fluorophore localization on a nanometer scale. Thus, photobleaching cannot degrade image quality, allowing for extended observation times. Super‐resolution transient amyloid binding microscopy promises to directly image native amyloid by using standard probes and record amyloid dynamics over minutes to days. We imaged amyloid fibrils from multiple polypeptides, oligomeric, and fibrillar structures formed during different stages of amyloid‐β aggregation, as well as the structural remodeling of amyloid‐β fibrils by the compound epi‐gallocatechin gallate.
Bullying and alexithymia: Are there differences between traditional, cyber, combined bullies, and nonbullies in reading their own emotions?
Authors: Wachs Sebastian , Wright Michelle F. 
Published: June 2018

AbstractBackgroundFew studies have examined alexithymia, the inability to identify or describe one's emotions, as a possible correlate of bullying.AimsTo investigate whether there are differences among 12–18 year‐olds in capacity for identifying and/or describing own emotions between traditional bullies, cyber bullies, combined bullies, and nonbullies.MethodsData from self‐report questionnaires completed by 897 female and 652 male 12–18 year‐olds (mean 14.5 years, standard deviation 1.68) from Germany and Thailand were analysed using analysis of covariance.ResultsYoung people who reported never having bullied others scored lower on the alexithymia scale than traditional, cyber, or combined bullies. There were no differences between traditional and cyber bullies on this measure, but those who operated in both ways had significantly higher alexithymia scores compared with those who bullied in just one modality.ConclusionAlexithymia is thus likely to be an important factor to consider in prevention and treatment of bullying. We recommend that prevention programmes include elements to help identify and describe one's own emotions, providing additional support, and “training” if alexithymia is identified. When young people use cyber techniques and traditional bullying methods, it seems likely that they will have greatest need in this respect.
Host–Guest and Photophysical Behavior of Ti8L12 Cube with Encapsulated [Ti(H2O)6] Species
Authors: Zhu Bang‐Chang , Fang Wei‐Hui , Wang Junhui , Du Yonghua , Zhou Tianhua , Wu Kaifeng , Zhang Lei , Zhang Jian 
Published: June 2018

AbstractTitanium‐based coordination cages could be interesting for both supramolecular and photophysical chemistry. This work reports an unprecedented host–guest system, [Ti(H2O)6]@Ti8L12, which is comprised of the first Ti‐based coordination cube and the unusual titanium aquo species. Due to the abundant intra‐cube O−H⋅⋅⋅O hydrogen bonds, the [Ti(H2O)6]@Ti8L12 complex is rather stable both in solid and solution states, confirmed by X‐ray diffraction and ESI‐MS analysis. The encapsulated [Ti(H2O)6] species shows influence on the light absorption, photoluminescent, and photocurrent properties. Moreover, ultrafast transient absorption spectroscopy has been applied to study the photodynamics of both free and [Ti(H2O)6] guest encapsulated Ti8L12 cube, confirming that the host–guest system produces a slightly longer‐lived excited state. Therefore, this work presents the first [Ti8L12] cube with unusual [Ti(H2O)6] guest and also provides an interesting supramolecular model for the host–guest photophysical study.
Electrochemical Synthesis of (Aza)indolines via Dehydrogenative [3+2] Annulation: Application to Total Synthesis of (±)‐Hinckdentine A
Authors: Hou Zhong‐Wei , Yan Hong , Song Jin‐Shuai , Xu Hai‐Chao 
Published: June 2018

AbstractAn electrochemical synthesis of functionalized (aza)indolines through dehydrogenative [3+2] annulation of arylamines with tethered alkenes has been developed. Previous reported syntheses through similar inter‐ and intramolecular annulation reactions required noble‐metal catalysts and are mostly limited to terminal alkenes or 1,3‐dienes. The electrosynthesis employs the easily available and inexpensive ferrocene as the molecular catalyst and is compatible with di‐, tri‐ and even tetrasubstituted alkenes to construct indolines as well as the more challenging azaindolines. Employing the newly developed electrosynthesis as a key step, the total synthesis of marine alkaloid (±)‐hinckdentine A has been achieved in 12 steps (longest linear sequence) from commercially available materials.
C‐reactive protein during and after myocardial infarction in relation to cardiac injury and left ventricular function at follow‐up
Authors: Vanhaverbeke Maarten , Veltman Denise , Pattyn Nele , De Crem Nico , Gillijns Hilde , Cornelissen Véronique , Janssens Stefan , Sinnaeve Peter R. 
Published: June 2018

BackgroundAcute myocardial infarction (MI) invokes a large inflammatory response, which contributes to myocardial repair.HypothesisWe investigated whether C‐reactive protein (CRP) measured during MI vs at 1 month follow‐up improves the prediction of left ventricular (LV) function.MethodsWe prospectively enrolled 131 consecutive patients with acute MI and without non‐cardiovascular causes of inflammation. We correlated admission and peak levels of CRP during hospitalization and high‐sensitivity (hs) CRP at 1 month follow‐up with markers of cardiac injury. Clinical follow‐up and echocardiography for LV function were performed at a mean of 17 months.ResultsMedian CRP levels were 1.89 mg/L on admission with MI, peaked to 12.10 mg/L during hospitalization and dropped to 1.24 mg/L at 1 month. Although admission CRP levels only weakly correlated with ejection fraction in the acute phase of MI (coefficient −0.164, P = 0.094), peak CRP was significantly related to ejection fraction (coefficient −0.4, P < 0.001), hsTroponin T (0.389, P < 0.001), and white blood cell count (0.389, P < 0.001). hsCRP at 1 month was not related to the extent of acute cardiac injury. These findings were replicated in an independent cohort of 57 patients. Peak CRP predicted LV dysfunction at follow‐up (OR 11.0, 3.1‐39.5 per log CRP, P < 0.001), persisting after adjustment for infarct size (OR 5.1, 1.1‐23.6, P = 0.037), while hsCRP at 1 month was unrelated to LV function at follow‐up.ConclusionshsCRP 1 month post‐MI does not relate to acute cardiac injury or LV function at follow‐up, but we confirm that peak CRP is an independent predictor of LV dysfunction at follow‐up.
Preparation, Culture, and Analysis of Amniotic Fluid Samples
Authors: Miron Patricia Minehart 
Published: June 2018

AbstractAmniotic fluid obtained via amniocentesis provides a source of fetal material used in prenatal diagnosis. The fluid may be used directly for biochemical analyses, fluorescence in situ hybridization (FISH), and isolation of DNA for molecular studies, including chromosomal microarray analysis (CMA). The fluid is typically cultured as a source of metaphase cells for chromosome analysis and to provide additional material for biochemical and DNA‐based testing. This unit describes an in situ method for the preparation, culture, and harvest of amniotic fluid samples for metaphase chromosome analysis. Cells are grown, harvested for metaphase spreads, and analyzed on glass coverslips. The unit also describes methods to obtain cells for additional studies (such as molecular genetic analyses) by growing cells in flasks either following passaging of cells from a glass coverslip culture or by directly establishing a flask culture from the amniotic fluid specimen. When cells are grown in flasks, they must be removed from the flask with trypsin before they can be used in studies. Lastly, this unit describes a method for isolating DNA for CMA from uncultured amniotic fluid and cultured cells. © 2018 by John Wiley & Sons, Inc.
Assessment of Consistency of Drug Interaction Information in Drug Labels Among the United States, the United Kingdom, China, Japan, and Korea
Authors: Jeong Sohyun , Kam Gyungmin , Li Junqing , Lee Sejin , Lee Hyesung , Noh Yunha , Shin Ju‐Young 
Published: June 2018

Information gap in drug labeling among countries create challenges in therapeutic use of drugs. We aimed to evaluate the consistency of drug interaction information in drug labels among five countries. The study drugs were chosen from the commonly approved drug list in the US, UK, China, Japan, and Korea. The degree of agreement of drug interaction data was evaluated by kappa coefficient. Thirty‐eight drugs were evaluated, and moderate degree of agreement was observed among all countries’ labeling (κ = 0.43, 95% confidence interval (CI) = 0.41–0.46). The degree of agreement was the highest for the UK and Korea (κ = 0.71, 95% CI = 0.67–0.75) and the lowest for the UK and Japan (κ = 0.02, 95% CI = 0.00–0.04). Information regarding drug interactions listed in the studied drug labels was not in high agreement. International standardization of drug labeling is required to ensure safe drug therapy.
A prediction and scheduling framework in centralized cognitive radio network for energy efficient non‐real time communication
Authors: Manna Tanumay , Misra Iti Saha 
Published: June 2018

SummaryAdvent of Internet of Things led to an exponential rise in battery‐operated sensors transmitting small non‐real time (NRT) data regularly. To this end, this work proposes a framework for centralized cognitive radio network (CRN) that facilitates better spectrum utilization and low‐cost opportunistic NRT data transfer with high energy efficiency. The novelty of this framework is to incorporate Hidden Markov Model–based prediction within the traditional cognitive radio sensing‐transmission cycle. To minimize the prediction time, we design a Hardware‐based Hidden Markov Model engine (H2M2) to be used by the cognitive base station (CBS). CBS exploits the H2M2 engine over high primary user (PU) activity channels to minimize the collisions between PUs and NRT secondary users, thereby reducing the SU energy consumption. However, this is at the cost of reduced throughput. Taking this into account, we propose an Intersensing‐Prediction Time Optimization algorithm that identifies the predictable PU activity channels and maximizes the throughput within a PU interference threshold. Furthermore, to minimize the total battery consumption of all the SUs within CRN, a Battery Consumption Minimizing Scheduler is designed at the CBS that efficiently allocates the predictable PU channels to the NRT SUs. By exploiting the unutilized high PU activity channels, the proposed Centralized Scheduling, Sensing and Prediction (CSSP) framework improves the spectral efficiency of the CRN. Exhaustive performance studies show that CSSP outperforms traditional nonpredictive sensing techniques in terms of energy efficiency and interference management. Finally, through a proof of concept, we validate the ability of CSSP framework in enabling NRT communication.
Novel signals for optimized timing synchronization in direct‐sequence spread‐spectrum communication systems
Authors: Landolsi Mohamed Adnan 
Published: June 2018

SummaryThe paper presents design techniques for novel signaling waveforms to optimize timing synchronization in direct‐sequence spread‐spectrum communication systems. Both coarse code timing acquisition and fine delay‐locked loop tracking systems are considered, and their performance metrics are analyzed in terms of initial acquisition detection probability and residual tracking jitter, showing a strong dependency on signal waveform spectral characteristics. Bit error performance under imperfect synchronization is also assessed. A design methodology is formulated with a low complexity parametric optimization approach based on prolate spheroidal waveform expansions for the generation of signals that minimize the probability of acquisition miss and tracking error jitter subject to additional constraints on signal energy and phase transitions. Novel optimized waveforms are synthesized with different levels of effective root mean square bandwidth occupancy and compared with conventional pulses to illustrate their advantages. Performance trade‐offs are demonstrated between the acquisition and tracking systems, whereby signals with low effective bandwidth are found to have better acquisition capability at the expense of poorer tracking jitter, while the converse holds for signals with higher effective bandwidth. It is found that an effective root mean square bandwidth occupancy in the range of 40% to 50% of the chip rate can achieve a good compromise between the requirements of the 2 code timing synchronization phases. Numerical results are presented to quantify the relative merits of representative waveforms with respect to the different performance measures in terms of acquisition capability, tracking jitter, and bit error probability.
ATLANTIC AMPHIBIANS: a data set of amphibian communities from the Atlantic Forests of South America
Authors: Vancine Maurício Humberto , Duarte Kauã da Silva , de Souza Yuri Silva , Giovanelli João Gabriel Ribeiro , Martins‐Sobrinho Paulo Mateus , López Ariel , Bovo Rafael Parelli , Maffei Fábio , Lion Marília Bruzzi , Ribeiro Júnior José Wagner , Brassaloti Ricardo , da Costa Carolina Ortiz Rocha , Sawakuchi Henrique Oliveira , Forti Lucas Rodriguez , Cacciali Pier , Bertoluci Jaime , Haddad Célio Fernando Baptista , Ribeiro Milton Cezar 
Published: June 2018

AbstractAmphibians are among the most threatened vertebrates in the world and this is also true for those inhabiting the Atlantic Forest hotspot, living in ecosystems that are highly degraded and threatened by anthropogenic activities. We present a data set containing information about amphibian communities sampled throughout the Atlantic Forest Biome in South America. The data were extracted from 389 bibliographic references (articles, books, theses, and dissertations) representing inventories of amphibian communities from 1940 to 2017. The data set includes 17,619 records of 528 species with taxonomic certainty, from 1,163 study sites. Of all the records, 14,450 (82%) were classified using the criterion of endemism; of those, 7,787 (44%) were considered endemic and 6,663 (38%) were not. Historically, multiple sampling methods were used to survey amphibians, the most representative methods being active surveys (82.1%), surveys at breeding sites (20%), pitfall traps (15.3%), and occasional encounters (14.5%). Species richness averaged 15.2 ± 11.3 (mean ± SD), ranging from 1 to 80 species per site. We found a low dominance in the communities, with 10 species occurring in about 26% of communities: Physalaemus cuvieri (4.1%), Dendropsophus minutus (3.8%), Boana faber (3.1%), Scinax fuscovarius (2.8%), Leptodactylus latrans (2.7%), Leptodactylus fuscus (2.6%), Boana albopunctata (2.3%), Dendropsophus nanus (1.6%), Rhinella ornata (1.6%), and Leptodactylus mystacinus (1.6%). This data set represents a major effort to compile inventories of amphibian communities for the Neotropical region, filling a large gap in the data on the Atlantic Forest hotspot. We hope this data set can be used as a credible tool in the proposal of new studies on amphibian sampling and even in the development of conservation planning for these taxa. This information also has great relevance for macroecological studies, being foundational for both conservation and restoration strategies in this biodiversity hotspot. No copyright or proprietary restrictions are associated with the use of this data set. Please cite this data paper when the data are used in publications or teaching events.
Which patients with heart failure should receive specialist palliative care?
Authors: Campbell Ross T. , Petrie Mark C. , Jackson Colette E. , Jhund Pardeep S. , Wright Ann , Gardner Roy S. , Sonecki Piotr , Pozzi Andrea , McSkimming Paula , McConnachie Alex , Finlay Fiona , Davidson Patricia , Denvir Martin A. , Johnson Miriam J. , Hogg Karen J. , McMurray John J.V. 
Published: June 2018

AimsWe investigated which patients with heart failure (HF) should receive specialist palliative care (SPC) by first creating a definition of need for SPC in patients hospitalised with HF using patient‐reported outcome measures (PROMs) and then testing this definition using the outcome of days alive and out of hospital (DAOH). We also evaluated which baseline variables predicted need for SPC and whether those with this need received SPC.Methods and resultsPROMs assessing quality of life (QoL), symptoms, and mood were administered at baseline and every 4 months. SPC need was defined as persistently severe impairment of any PROM without improvement (or severe impairment immediately preceding death). We then tested whether need for SPC, so defined, was reflected in DAOH, a measure which combines length of stay, days of hospital re‐admission, and days lost due to death. Of 272 patients recruited, 74 (27%) met the definition of SPC needs. These patients lived one third fewer DAOH than those without SPC need (and less than a quarter of QoL‐adjusted DAOH). A Kansas City Cardiomyopathy Questionnaire (KCCQ) summary score of <29 identified patients who subsequently had SPC needs (area under receiver operating characteristic curve 0.78). Twenty‐four per cent of patients with SPC needs actually received SPC (n = 18).ConclusionsA quarter of patients hospitalised with HF had a need for SPC and were identified by a low KCCQ score on admission. Those with SPC need spent many fewer DAOH and their DAOH were of significantly worse quality. Very few patients with SPC needs accessed SPC services.
Sca‐1+ cardiac fibroblasts promote development of heart failure
Authors: Chen Guobao , Bracamonte‐Baran William , Diny Nicola L. , Hou Xuezhou , Talor Monica V. , Fu Kai , Liu Yue , Davogustto Giovanni , Vasquez Hernan , Taegtmeyer Heinrich , Frazier O. Howard , Waisman Ari , Conway Simon J. , Wan Fengyi , Čiháková Daniela 
Published: June 2018

AbstractThe causative effect of GM‐CSF produced by cardiac fibroblasts to development of heart failure has not been shown. We identified the pathological GM‐CSF‐producing cardiac fibroblast subset and the specific deletion of IL‐17A signaling to these cells attenuated cardiac inflammation and heart failure. We describe here the CD45−CD31−CD29+mEF‐SK4+PDGFRα+Sca‐1+periostin+ (Sca‐1+) cardiac fibroblast subset as the main GM‐CSF producer in both experimental autoimmune myocarditis and myocardial infarction mouse models. Specific ablation of IL‐17A signaling to Sca‐1+periostin+ cardiac fibroblasts (PostnCreIl17rafl/fl) protected mice from post‐infarct heart failure and death. Moreover, PostnCreIl17rafl/fl mice had significantly fewer GM‐CSF‐producing Sca‐1+ cardiac fibroblasts and inflammatory Ly6Chi monocytes in the heart. Sca‐1+ cardiac fibroblasts were not only potent GM‐CSF producers, but also exhibited plasticity and switched their cytokine production profiles depending on local microenvironments. Moreover, we also found GM‐CSF‐positive cardiac fibroblasts in cardiac biopsy samples from heart failure patients of myocarditis or ischemic origin. Thus, this is the first identification of a pathological GM‐CSF‐producing cardiac fibroblast subset in human and mice hearts with myocarditis and ischemic cardiomyopathy. Sca‐1+ cardiac fibroblasts direct the type of immune cells infiltrating the heart during cardiac inflammation and drive the development of heart failure.
Improving Quality Preservation of Raw Peanuts Stored under Different Conditions During a Long‐Term Storage
Authors: Martín María Paula , Asensio Claudia Mariana , Nepote Valeria , Grosso Nelson Rubén 
Published: June 2018

This research evaluated the chemical, microbiological, and sensory quality preservation of raw peanuts packed in high barrier ethylene vinyl alcohol bags (EVOH) under vacuum and in polypropylene (PP) bags, during 720 days of storage at 10° (T10) and 25 °C (T25). Peroxides (PV) and conjugated dienes (CD) remained almost stable in EVOH at 10 °C (EVOH‐T10). The free fatty acid increase was greater in peanuts packaged in EVOH at 25 °C than at 10 °C. EVOH‐T10 presented the lowest saturated/unsaturated and oleic/linoleic ratios, and the highest iodine values. The lowest γ‐tocopherol decrease was for EVOH‐T10. Peanuts stored in PP bags at 25 °C (PP‐T25) showed the highest alkanes and the lowest decane,5,6‐bis(2,2‐dimethylpropylidene)‐,(E,Z)‐ content at the end of storage. PP‐T25 had the highest rate of roasted peanutty flavor decrease. Less than 10 CFU g−1 molds, yeasts, and aerobic mesophilic bacteria are detected for peanut samples, irrespective of packaging and storage temperature. Storage at 10 °C is associated with lesser quality deterioration than storage at 25 °C. All studied quality parameters are better preserved in raw peanuts packaged in EVOH except for free fatty acids.Practical Applications: Raw peanuts are used as primary ingredients which can be converted into value‐added products like peanut butter, peanut flour, peanut oil, snacks, and other by‐products. Nevertheless, preserving raw peanut quality has become a critical issue for peanut industry owing to peanut susceptibility to deterioration process. This research presents results about the chemical and sensory quality parameter changes of raw peanuts stored under different packaging materials and temperatures during a long‐term storage to figure out which are better conditions to preserve raw peanuts as a high‐quality product.Raw peanut quality preservation under a long‐term storage period packed in high barrier plastic bags (EVOH) under vacuum and polypropylene bags (PP) stored at refrigeration temperatures (T10) and room temperature (T25).
A risk‐based life cycle cost strategy for optimal design and evaluation of control methods for nonlinear structures
Authors: El‐Khoury Omar , Shafieezadeh Abdollah , Fereshtehnejad Ehsan 
Published: June 2018

SummaryThe lack of direct correspondence between control objectives and hazard risks over the lifetime of systems is a key shortcoming of current control techniques. This along with the inability to objectively analyze the benefits and costs of control solutions compared with conventional methods has hindered widespread application of control systems in seismic regions. To address these gaps, this paper offers 2 new contributions. First, it introduces risk‐based life cycle–cost (LCC) optimal control algorithms, where LCC is incorporated as the performance objective in the control design. Two strategies called risk‐based linear quadratic regulator and unconstrained risk‐based regulator are subsequently proposed. The considered costs include the initial cost of the structure and control system, LCC of maintenance, and probabilistically derived estimates of seismic‐induced repair costs and losses associated with downtime, injuries, and casualties throughout the life of the structure. This risk‐based framework accounts for uncertainties in both system properties and hazard excitations and uses outcrossing rate theory to estimate fragilities for various damage states. The second contribution of this work is a risk‐based probabilistic framework for LCC analysis of existing and proposed control strategies. The proposed control designs are applied to the nonlinear model of a 4‐story building subjected to seismic excitations. Results show that these control methods reduce the LCC of the structure significantly compared with the status quo option (benefits of up to $1 351 000). The advancements offered in this paper enhance the cost‐effectiveness of control systems and objectively showcase their benefits for risk‐informed decision making.