bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Care for Mitochondrial Disorders in Canada: A Survey of Physicians
Authors: Paik Karen , Lines Matthew A. , Chakraborty Pranesh , Khangura Sara D. , Latocki Maureen , Al-Hertani Walla , Brunel-Guitton Catherine , Khan Aneal , Penny Blaine , Rockman-Greenberg Cheryl , Rupar C. Anthony , Sondheimer Neal , Tarnopolsky Mark , Tingley Kylie , Coyle Doug , Dyack Sarah , Feigenbaum Annette , Geraghty Michael T. , Gillis Jane , van Karnebeek Clara D. M. , Kronick Jonathan B. , Little Julian , Potter Murray , Siriwardena Komudi , Sparkes Rebecca , Turner Lesley A. , Wilson Kumanan , Buhas Daniela , Potter Beth K. ,   in collaboration with the Canadian Inherited Metabolic Diseases Research Network
Published: August 2019

ABSTRACT:Background:An improved understanding of diagnostic and treatment practices for patients with rare primary mitochondrial disorders can support benchmarking against guidelines and establish priorities for evaluative research. We aimed to describe physician care for patients with mitochondrial diseases in Canada, including variation in care.Methods:We conducted a cross-sectional survey of Canadian physicians involved in the diagnosis and/or ongoing care of patients with mitochondrial diseases. We used snowball sampling to identify potentially eligible participants, who were contacted by mail up to five times and invited to complete a questionnaire by mail or internet. The questionnaire addressed: personal experience in providing care for mitochondrial disorders; diagnostic and treatment practices; challenges in accessing tests or treatments; and views regarding research priorities.Results:We received 58 survey responses (52% response rate). Most respondents (83%) reported spending 20% or less of their clinical practice time caring for patients with mitochondrial disorders. We identified important variation in diagnostic care, although assessments frequently reported as diagnostically helpful (e.g., brain magnetic resonance imaging, MRI/MR spectroscopy) were also recommended in published guidelines. Approximately half (49%) of participants would recommend “mitochondrial cocktails” for all or most patients, but we identified variation in responses regarding specific vitamins and cofactors. A majority of physicians recommended studies on the development of effective therapies as the top research priority.Conclusions:While Canadian physicians’ views about diagnostic care and disease management are aligned with published recommendations, important variations in care reflect persistent areas of uncertainty and a need for empirical evidence to support and update standard protocols.
Dissecting Sites of Punishment: Penal Colonies and Their Borders
Authors: Popova Zhanna , Di Pasquale Francesca 
Published: August 2019

AbstractAlthough a crucial element of imperial architecture, non-metropolitan penal colonies remain relatively understudied, compared with the richness of historical scholarship on modern prison systems in Western Europe and its offshoots. Complementing the perspective chosen in the recentInternational Review of Social HistorySpecial Issue 26, “Transportation, Deportation and Exile: Perspectives from the Colonies in the Nineteenth and Twentieth Centuries”, the four articles in this Special Theme propose an additional angle of investigation of the role of convicts in the incorporation of new territories into colonial empires. The authors place sites of punishment, rather than flows of convicts, at the core of their reflection, and provide a close-up analysis of circulations of information and people across the borders of penal sites on various scales: local, trans-regional, and international. They problematize the notion of “border”, and consider it as a vantage point that leads to a new conceptualization of the penal colony as a system that expands in its surroundings and, in turn, assimilates external political, social, and economic stimuli. Relying on several distinct methodological approaches, the authors foreground the specificities of colonial punishment and demonstrate how punishment became part of the creation and maintenance of power inequalities between the colonies and the metropoles.
The Disputed Constitutionality of the Precedential Practice of the Federal Supreme Court and Its Implications for Oromia Family Law: The Case of Bigamous Marriage in Ethiopia
Authors: Hirko Sileshi Bedasie 
Published: August 2019

AbstractThe practice of cassation over cassation and its consequent rule of precedent have resulted in a legal quagmire. The impact is evident in the pecuniary disposition of a bigamous marriage with far-reaching legal ramifications for a valid marriage in Ethiopia. In fact, the pecuniary consequences of a bigamous marriage have remained a perplexing challenge in Ethiopia due to, inter alia, the debatable precedential practice of the Federal Supreme Court. Given the constitutionally guaranteed regional autonomy of the regional states to regulate family matters in Ethiopia, the practice has constitutional implications for the application of the Oromia Family Code. This article argues that the federal doctrine of precedent and its enabling legislation not only lack a concrete constitutional basis, but also encroach upon the constitutional autonomy of regional states and the constitutional rights of legitimate spouses. Exploring the constitutional dimensions of the practice and its legal ramifications, the article suggests possible options to change the practice at a regional level.
Dietary habits of newcomer children in Canada
Authors: Lane Ginny , Nisbet Christine , Vatanparast Hassan 
Published: August 2019

AbstractObjective:To explore the dietary habits, nutrient adequacies and dietary change experiences of immigrant and refugee children.Design:Mixed-methods cross-sectional design. Children completed three 24 h dietary recalls to determine nutrient inadequacies. Parents and service providers were interviewed to capture dietary practices.Setting:Healthy Immigrant Children study, Saskatchewan, Canada.Participants:Three hundred immigrant and refugee children aged 3–13 years and twenty-two parents who lived in Regina or Saskatoon for less than 5 years; twenty-four newcomer services providers.Results:Immigrant children had higher mean intakes of meat and alternatives, milk and alternatives, and whole grains; and consumed more vitamin B12, folate, Ca, vitamin D, Fe and Zn compared with refugee children. Refugee children were at higher risk of having inadequate intakes of folate (37 %) and Fe (18 %). Both immigrant and refugee children were at high risk of inadequate vitamin D (87 and 93 %, respectively) and Ca intakes (79 and 80 %), and a substantial portion were at risk for inadequate Zn intake (21 and 31 %). Participants mentioned challenges with maintaining a healthy traditional diet in the midst of a busy schedule, while responding to their children’s demands for foods high in fat and sugar.Conclusions:Newcomer children are at risk for inadequate intakes of vitamin D, Ca and Zn, while refugee children are at additional risk for inadequate folate and Fe intakes. Newcomers to Canada may experience subtle or drastic changes in their food environment leading to dietary acculturation that includes increased consumption of foods high in sugar, salt and fat.
Food insecurity and dietary intake by Supplemental Nutrition Assistance Program participation status among mainland US Puerto Rican adults after the 2009 American Recovery and Reinvestment Act
Authors: McClain Amanda C , Tucker Katherine L , Falcón Luis M , Mattei Josiemer 
Published: August 2019

AbstractObjective:The 2009 American Recovery and Reinvestment Act (ARRA) increased monthly Supplemental Nutrition Assistance Program (SNAP) benefits and expanded SNAP eligibility, yet limited evidence exists on the potential impact of ARRA on dietary intake among at-risk individuals. We aimed to examine pre-/post-ARRA differences in food insecurity (FI) and dietary intake by SNAP participation status.Design:Pre/post analysis.Setting:Boston, MA, USA.Participants:Data were from the longitudinal Boston Puerto Rican Health Study (2007–2015). The US Department of Agriculture ten-item adult module assessed FI. A validated FFQ assessed dietary intake. Diet quality was assessed using the Alternate Healthy Eating Index-2010 (AHEI-2010). Self-reported pre-/post-ARRA household SNAP participation responses were categorized as: sustained (n 249), new (n 95) or discontinued (n 58). We estimated differences in odds of FI and in mean nutrient intakes and AHEI-2010 scores post-ARRA.Results:Compared with pre-ARRA, OR (95 % CI) of FI post-ARRA were lower for all participants (0·69 (0·51, 0·94)), and within sustained (0·63 (0·43, 0·92)) but not within new (0·94 (0·49, 1·80)) or discontinued (0·63 (0·25, 1·56)) participants. Post-ARRA, total carbohydrate intake was higher, and alcohol intake was lower, for sustained and new participants, and dietary fibre was higher for sustained participants, compared with discontinued participants. Scores for AHEI-2010 and its components did not differ post-ARRA, except for lower alcohol intake for sustained v. discontinued participants.Conclusions:Post-ARRA, FI decreased for sustained participants and some nutrient intakes were healthier for sustained and new participants. Continuing and expanding SNAP benefits and eligibility likely protects against FI and may improve dietary intake.
Image Segmentation for FIB-SEM Serial Sectioning of a Si/C–Graphite Composite Anode Microstructure Based on Preprocessing and Global Thresholding
Authors: Kim Dongjae , Lee Sihyung , Hong Wooram , Lee Hyosug , Jeon Seongho , Han Sungsoo , Nam Jaewook 
Published: August 2019

AbstractThe choice of materials that constitute electrodes and the way they are interconnected, i.e., the microstructure, influences the performance of lithium-ion batteries. For batteries with high energy and power densities, the microstructure of the electrodes must be controlled during their manufacturing process. Moreover, understanding the microstructure helps in designing a high-performance, yet low-cost battery. In this study, we propose a systematic algorithm workflow for the images of the microstructure of anodes obtained from a focused ion beam scanning electron microscope (FIB-SEM). Here, we discuss the typical issues that arise in the raw FIB-SEM images and the corresponding preprocessing methods that resolve them. Next, we propose a Fourier transform-based filter that effectively reduces curtain artifacts. Also, we propose a simple, yet an effective, global-thresholding method to identify active materials and pores in the microstructure. Finally, we reconstruct the three-dimensional structures by concatenating the segmented images. The whole algorithm workflow used in this study is not fully automated and requires user interactions such as choosing the values of parameters and removing shine-through artifacts manually. However, it should be emphasized that the proposed global-thresholding method is deterministic and stable, which results in high segmentation performance for all sectioning images.
Controls on Fore‐Arc Deformation and Stress Switching After the Great 2011 Tohoku‐Oki Earthquake From Discrete Numerical Simulations
Authors: Wang Xiaoyu , Morgan Julia K. 
Published: August 2019

AbstractThe large magnitude of the 2011 Mw 9.0 Tohoku‐Oki earthquake, which occurred off the east coast of Japan, was not expected or predicted by any previous studies. One surprising observation was the sudden change in stress state; local earthquakes confirmed a compressional stress state before the main shock, whereas an extensional stress state was evident after the main shock. Using discrete element method modeling, this project attempts to reproduce the stress change after the main shock, and explores the conditions that can cause stress switching both onshore and offshore Tohoku. Our simulations demonstrate that rapid fault weakening can produce stress change and predominant normal‐fault earthquake mechanisms in the upper plate of Tohoku‐Oki. Several specific conditions seem to favor such stress switching; the megathrust fault must have been frictionally strong before the main shock, and comparable values of internal (μinternal) and basal friction (μbasal) are necessary to cause the formation of widespread normal faults within the wedge. Furthermore, dynamic extension during elastic unloading appears to play an important role in accommodating stress changes and wedge deformation in the Tohoku area; these cannot be explained solely based on Critical Coulomb Wedge models, but instead require dynamic unloading processes.
Zeeman-type spin splitting in nonmagnetic three-dimensional compounds
Authors: Mera Acosta Carlos , Fazzio Adalberto , Dalpian Gustavo M. 
Published: August 2019

AbstractDespite its potential for device application, the nonmagnetic Zeeman effect has only been predicted and observed in two-dimensional compounds. We demonstrate that noncentrosymmetric three-dimensional compounds can also exhibit a Zeeman-type spin splitting, allowing the splitting control by changing the growth direction of slabs formed by these compounds. We determine the required conditions for this effect: (i) noncentrosymmetric including polar and nonpolar point groups, (ii) valence band maximum or conduction band minimum in a generic k-point, i.e., non-time-reversal-invariant momentum, and (iii) zero magnetic moment. Using these conditions as filters, we perform a material screening to systematically search for these systems in the AFLOW-ICSD database. We find 20 candidates featuring the Zeeman-type effect. We also find that the spin splitting in confined systems can be controlled by an external electric field, which in turns can induce a metal–insulator transition. We believe that this work will open the way for the discovery of novel fundamental effects related to the spin polarization control.
Evidence for tritium persistence as organically bound forms in river sediments since the past nuclear weapon tests
Authors: Eyrolle Frédérique , Copard Yoann , Lepage Hugo , Ducros Loic , Morereau Amandine , Grosbois Cécile , Cossonnet Catherine , Gurriaran Rodolfo , Booth Shawn , Desmet Marc 
Published: August 2019

AbstractTritium of artificial origin was initially introduced to the environment from the global atmospheric fallout after nuclear weapons tests. Its level was increased in rainwaters by a factor 1000 during peak emissions in 1963 within the whole northern hemisphere. Here we demonstrate that tritium from global atmospheric fallout stored in sedimentary reservoir for decades as organically bound forms in recalcitrant organic matter while tritium released by nuclear industries in rivers escape from such storages. Additionally, we highlight that organically bound tritium concentrations in riverine sediments culminate several years after peaking emission in the atmosphere due to the transit time of organic matter from soils to river systems. These results were acquired by measuring both free and bound forms of tritium in a 70 year old sedimentary archive cored in the Loire river basin (France). Such tritium storages, assumed to be formed at the global scale, as well as the decadal time lag of tritium contamination levels between atmosphere and river systems have never been demonstrated until now. Our results bring new lights on tritium persistence and dynamics within the environment and demonstrate that sedimentary reservoir constitute both tritium sinks and potential delayed sources of mobile and bioavailable tritium for freshwaters and living organisms decades after atmospheric contamination.
Sleeping Beauty Transposon-Mediated Asparaginase Gene Delivery by a Nanoparticle Platform
Authors: Chang Jen-Hsuan , Mou Kurt Yun , Mou Chung-Yuan 
Published: August 2019

AbstractTransgenic genome integration using non-viral vehicles is a promising approach for gene therapy. Previous studies reported that asparagine is a key regulator of cancer cell amino acid homeostasis, anabolic metabolism and cell proliferation. The depletion of asparagine would inhibit the growth of many cancer cells. In this study, we develop a nanoparticle delivery system to permanently integrate the asparaginase gene into the genome of human lung adenocarcinoma cells. The asparaginase plasmid and the Sleeping Beauty plasmid were co-transfected using amine-functionalized mesoporous nanoparticles into the human lung adenocarcinoma cells. The intracellular asparaginase expression led to the cell cytotoxicity for PC9 and A549 cells. In addition, the combination of the chemotherapy and the asparaginase gene therapy additively enhanced the cell cytotoxicity of PC9 and A549 cells to 69% and 63%, respectively. Finally, we showed that the stable cell clones were successfully made by puromycin selection. The doxycycline-induced expression of asparaginase caused almost complete cell death of PC9 and A549 asparaginase-integrated stable cells. This work demonstrates that silica-based nanoparticles have great potential in gene delivery for therapeutic purposes.
Tpz1TPP1 prevents telomerase activation and protects telomeres by modulating the Stn1-Ten1 complex in fission yeast
Authors: Mennie Amanda K. , Moser Bettina A. , Hoyle Alice , Low Ross S. , Tanaka Katsunori , Nakamura Toru M. 
Published: August 2019

AbstractIn both mammalian and fission yeast cells, conserved shelterin and CST (CTC1-STN1-TEN1) complexes play critical roles in protection of telomeres and regulation of telomerase, an enzyme required to overcome the end replication problem. However, molecular details that govern proper coordination among shelterin, CST, and telomerase have not yet been fully understood. Here, we establish a conserved SWSSS motif, located adjacent to the Lys242 SUMOylation site in the fission yeast shelterin subunit Tpz1, as a new functional regulatory element for telomere protection and telomere length homeostasis. The SWSSS motif works redundantly with Lys242 SUMOylation to promote binding of Stn1-Ten1 at telomere and sub-telomere regions to protect against single-strand annealing (SSA)-dependent telomere fusions, and to prevent telomerase accumulation at telomeres. In addition, we provide evidence that the SWSSS motif defines an unanticipated role of Tpz1 in limiting telomerase activation at telomeres to prevent uncontrolled telomere elongation.
Improving Reading Comprehension in the Primary Grades: Mediated Effects of a Language-Focused Classroom Intervention
Authors:   Language and Reading Research Consortium (LARRC), Jiang Hui , Logan Jessica 
Published: August 2019

Purpose
This article includes results from a multistate randomized controlled trial designed to investigate the impacts of a language-focused classroom intervention on primary grade students' proximal language skills and distal reading comprehension skills.

Method
The sample included 938 children from 160 classrooms in 4 geographic regions in the United States; each classroom was randomly assigned to 1 of 2 experimental conditions (2 variations of a language-focused intervention) or business-as-usual control. For this study, the 2 experimental conditions were collapsed, as they represented minor differences in the language-focused intervention. All children completed assessments at multiple time points during the academic year. Proximal measures (curriculum-aligned measures of vocabulary, comprehension monitoring, and understanding narrative and expository text) were administered throughout the school year. Distal measures of reading comprehension were administered at the beginning and the end of the school year.

Results
Multilevel multivariate regression was conducted with results showing that students receiving the language-focused intervention significantly outperformed those in the control group in comprehension monitoring and vocabulary, with effect sizes ranging from 0.55 to 1.98. A small effect in understanding text (narrative) was found in 3rd grade only. Multilevel path analyses were then conducted to examine if the intervention had a positive impact on reading comprehension through the influence of proximal language outcomes. In all 3 grades, instruction impacted reading comprehension via the mediation of vocabulary, with sizable effects (1.89–2.26); no other indirect pathways were significant.

Conclusions
This study provides evidence that a language-focused intervention can positively impact students' performance on language measures that are closely aligned with the intervention, with indirect, large effects on distal reading comprehension measures. Theoretically, this study provides causally interpretable support for the language bases of reading comprehension.
A Dynamic Magnetic Resonance Imaging–Based Method to Examine In Vivo Levator Veli Palatini Muscle Function During Speech
Authors: Pelland Catherine M. , Feng Xue , Borowitz Kathleen C. , Meyer Craig H. , Blemker Silvia S. 
Published: August 2019

Purpose
The aim of this study was to develop a method able to quantify levator veli palatini (LVP) muscle shortening and contraction velocities using dynamic magnetic resonance imaging (MRI) throughout speech samples and relate these measurements to velopharyngeal portal dimensions.

Method

Six healthy adults (3 men and 3 women,
M
= 24.5 years) produced syllables representing 4 different manners of production during real-time dynamic MRI scans. We acquired an oblique-coronal slice of the velopharyngeal mechanism, which captured the length of the LVP, and manually segmented each frame. LVP shortening and muscle velocities were calculated from the acquired images.

Results
Using our method, we found that subjects demonstrated greater LVP shortening and higher maximum contraction velocities during fricative and plosive syllable production than during nasal or vowel syllable production. LVP shortening and maximum contraction velocity positively correlated with velopharyngeal port depth.

Conclusions
In vivo LVP function differs between manners of production, as expected, and an individual's velopharyngeal portal dimensions influence LVP function. These measures, contextualized with the force–length and force–velocity muscle relationships, provide new insight into LVP function. Future studies could use this method to investigate LVP function in healthy speakers and individuals with velopharyngeal dysfunction and how function relates to velopharyngeal anatomy.
Revisiting Kepler-444
Authors: Buldgen G. , Farnir M. , Pezzotti C. , Eggenberger P. , Salmon S. J. A. J. , Montalban J. , Ferguson J. W. , Khan S. , Bourrier V. , Rendle B. M. , Meynet G. , Miglio A. , Noels A. 
Published: August 2019

Context. The CoRoT andKeplermissions have paved the way for synergies between exoplanetology and asteroseismology. The use of seismic data helps providing stringent constraints on the stellar properties which directly impact the results of planetary studies. Amongst the most interesting planetary systems discovered byKepler, Kepler-444 is unique by the quality of its seismic and classical stellar constraints. Its magnitude, age and the presence of 5 small-sized planets orbiting this target makes it an exceptional testbed for exoplanetology.Aims. We aim at providing a detailed characterization of Kepler-444, focusing on the dependency of the results on variations of key ingredients of the theoretical stellar models. This thorough study will serve as a basis for future investigations of the planetary evolution of the system orbiting Kepler-444.Methods. We use local and global minimization techniques to study the internal structure of the exoplanet-host star Kepler-444. We combine seismic observations from theKeplermission,GaiaDR2 data, and revised spectroscopic parameters to precisely constrain its internal structure and evolution.Results. We provide updated robust and precise determinations of the fundamental parameters of Kepler-444 and demonstrate that this low-mass star bore a convective core during a significant portion of its life on the main sequence. Using seismic data, we are able to estimate the lifetime of the convective core to approximately 8 Gyr out of the 11 Gyr of the evolution of Kepler-444. The revised stellar parameters found by our thorough study areM = 0.754 ± 0.03 M⊙,R = 0.753 ± 0.01 R⊙, and Age = 11 ± 1 Gyr.