bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tolerability and safety of strong opioid analgesics in children and adolescents with incurable oncological diseases
Authors: Pshonkin Alexey V. , Serkova Iruna V. , Zhukov Nikolay V. , Shukin Vladislav V. , Polevichenko Elena V. , Spiridonova Elena A. 
Published: August 2019

Relevance. One of the basic tasks of palliative medical care is to control pain in an incurable patient. To administer strong opioid analgesics as basic pain management in terminal patients, a treating physician must understand the risk of opioid-related adverse effects. According to the World Health Organization, the occurrence of the pain syndrome and importance of correct analgesic therapy in children and adolescents with incurable oncological diseases are underestimated.Purpose. To improve the quality of palliative medical care provided to children and adolescents with incurable oncological diseases.Materials and methods. A retrospective and prospective study was carried out. 400 patients with incurable oncological diseases aged 0 months to 20 years (median 9 years) were included into the study from June 2014 to December 2017, in particular, 235 boys and 165 girls (189 patients with extracranial solid tumors, 117 patients with CNS tumors and 94 patients with hemoblastoses). The study was approved by the Independent Ethics Committee and the Council of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology (Protocol No. 5 dated May 21, 2013). Of 284 patients with the pain syndrome, 227 (80%) of children and adolescents aged 0–20 years (median 12 years) used strong opioid analgesics (morphine hydrochloride, morphine sulfate and transdermal therapeutic system with fentanyl) for pain relief. Their dosage was set in accordance with WHO 2012 recommendations related to the management of persisting pain syndrome in children. To estimate the severity of adverse events (AE) when strong opioids were used (nausea, vomiting, constipation, skin itching, urinary retention and respiratory failure), the CTCAE (Common Terminology Criteria for Adverse Events) displays Grades 1 through 5. Opioid-induced hyperalgesia and opioid-induced neurotoxicity were estimated by clinical signs (absence or presence of a symptom).Results. Of 227 patients, 59 (26%) patients had AE associated with the administration of strong opioid analgesics: 11.5% of cases for constipation, 7.5% cases for nausea, 4% of cases for pruritus, 2.2% of cases for urinary retention, 0.44% of cases for opioid-induced hyperalgesia, 0.44% of cases for opioid-induced neurotoxicity. No respiratory failure was noted when strong opioid analgesics were used. In the majority of cases (95%), the registered AE were mild and required no termination of therapy with opioid analgesics. Of 284 patients, 281 (98.9%) underwent analgesic therapy with complete pain management.Conclusion. Strong opioid analgesics are safe and effective in children and adolescents with incurable oncological diseases.
Topographical and geological factors on gully-type debris flow in Malai River catchment, Siwaliks, Nepal
Authors: Bhandari Bharat Prasad , Dhakal Subodh 
Published: August 2019

The Siwalik hill of Nepal lies in between the two major thrusts; Main boundary Thrust and Main Frontal Thrust. Thrusting and continuous erosion of material from surface causes several landslides and debris flow problem in the Siwalik region. Debris flow commonly occurs after landslide during heavy rainfall in the steep slope. This paper described about the topographical and geological controls on debris flow occurring in gullies in the Siwaliks of the Malai River catchment of mid-Western Nepal. The length of gully, length of debris channel, area of debris channel, area of catchment of debris flow, area of gully without debris flow were found using Google earth pro, a free version online database. Similarly, a form factor (F), average gradient of stream, slope area ratio and a topographical factor (T) were calculated. Lithology and geological structure were studied in the field. The relation between each factor was identified.
Gully having larger debris flow event had T value greater than 0.01 and that having small debris flow event had T value less than 0.01. Gully without debris flow had T value less than 0.001. Gully having debris flow had F more than 0.1 and that free from debris flow had F less than 0.1. Both topographic and form factors were found greater than 0.1 at the hanging wall of the Malai Thrust, where large size debris flows were encountered. The T and F values obtained from the Middle and Upper Siwaliks were greater than 0.1.The number of debris flow events and large debris flows were found high the in the Middle and the Upper Siwaliks, and hanging wall of the Malai Thrust.
Analysis Signage Systems Based on Local Wisdom: Study Case Setu Babakan
Authors: Tjhin Santo 
Published: August 2019

Betawiâ€™s culture such as dance, food, and language is increasingly eroded. It can be said that it is gradually become extinct and this is due to the influence of technology developments. The government has taken many steps to preserve the Betawi culture, one of which is the placement of Condet region in East Jakarta for the development and preservation of Betawiâ€™s culture. Recently, the DKI Jakarta Government takes steps to preserve the pride and mascot of Jakarta city, which is the Betawi culture in Setu Babakan.
The word setu or "situ" itself means lake, while babakan means wood fiber. In the area of Setu Babakan, the provincial government provides a variety of facilities such as educational facilities as a learning area for Betawi culture and other various entertainments related to Betawi culture. Setu babakan has transformed from a lake into a tourism area, so it becomes one of the alternative tourism spot for local residents and foreign tourists.
The large area requires a signpost or commonly called signage, this is very important because signage is part of wayfinding, which has a role in providing direction inside the city. Indirect signage plays role in improving the flow system of visitors, so that there will be no accumulation in one particular location. At present, the condition of the signage area is already exist, but it has not been maximized in the role of its function as a signpost. In terms of aesthetics and design, the existing signage does not display the elements of Betawi culture which should be represented through signage.
MUATAN KEARIFAN LOKAL DALAM CERITA RAKYAT KEPULAUAN RIAU
Authors: Leoni Tessa Dwi , Indrayatti Wahyu 
Published: August 2019

This study aims to describe: (1) local wisdom reflected in the folklore Kepulaun Riau viewed from the view of life (philosophy); (2) the local wisdom reflected in the Kepulauan Riau folklore is seen from the attitude of social life, counsel, and iktibar; (3) local wisdom reflected in Kepulauan Riau folklore as seen from ceremonies or traditional ceremonies; (4) the local wisdom reflected in the Kepulauan Riau folklore is seen from the principles, norms and rules of rule embodied into a social system; and (5) the local wisdom reflected in Kepulauan Riau folklore is seen from the habits, everyday behavior of social intercourse. The problem is analyzed based on folklore theory. The method used in this research is descriptive method of analysis. This object is collected by observation ; recording and interviews. Data analysis technique is done by content analysis technique. Based on the results of the study, folklore is still growing in Kepulauan Riau society. The folklore is so full of values. it also reflects local wisdom of local people who can show the pattern of customs and local cultural peculiarities. The findings of this study can be used as a basic backdrop for literary and cultural researchers to study the culture of Indonesia in general and Malay culture of Kepulauan Riau in particular. Furthermore, for the people of Kepulauan Riau itself, the findings is one of conservation efforts of Malay culture in Kepulauan Riau. In addition, the results of this study can be an alternative teaching materials, one of which can be arranged in Prosa Fiction textbook.
Keywards: Local wisdom, Folklore, Kepulauan Riau
Pengembangan Instrumen Penilaian Literasi Kelautan untuk Siswa Sekolah Menengah Atas
Authors: Hindrasti Nur eka kusuma 
Published: August 2019

ABSTRACTThe preliminary study of students' understanding of the sea, where the sea is an important object in maritime affairs, is very much needed to support the academic curriculum which was initiated by the Indonesian Government. Understanding of the sea internationally has been widely studied in ocean literacy. Studies on marine literacy in Indonesia are still very few, even though Indonesia is the second country with the longest coastline in the world. Ocean literacy instruments need to be developed in advance to conduct a preliminary study of ocean literacy. The purpose of this study was to produce a valid and reliable ocean literacy assessment instrument for high school students. The stages in developing instruments include: designing, testing, determining validity, and determining the reliability of the instrument. The results of the study showed that ocean literacy instruments included a ocean insight test, questionnaire of student's attitude towards the sea, and questionnaire of student's behavior towards the sea. The instruments that have been produced was valid and reliable.
Keywords: instrument of ocean literacy
ABSTRAKKajian awal mengenai pemahaman siswa terhadap laut, dimana laut adalah objek penting dalam kemaritiman, sangat dibutuhkan untuk mendukung kurikulum kemairitiman yang mulai digagas oleh Pemerintah Indonesia. Pemahaman terhadap laut secara internasional telah banyak dikaji dalam literasi kelautan (ocean literacy). Kajian tentang literasi kelautan di Indonesia masih sangat sedikit, padahal Indonesia adalah negara kedua dengan garis pantai terpanjang sedunia. Instrumen literasi kelautan perlu dikembangkan terlebih dahulu guna melakukan kajian awal mengenai literasi kelautan. Tujuan penelitian ini adalah menghasilkan instrumen penilaian literasi kelautan untuk siswa SMA yang valid dan reliabel. Tahapan dalam pengembangan instrumen mencakup: perancangan, uji coba, penetapan validitas, dan penetapan realibilitas instrumen. Hasil penelitian menunjukkan bahwa instrumen literasi kelautan meliputi tes wawasan kelautan, angket sikap kepedulian siswa terhadap laut, dan angket perilaku siswa terhadap laut. Instrumen yang dihasilkan valid dan reliable.
Comparative Two-dimensional Gel Electrophoresis Maps for Amastigote-like Proteomes of Iranian Leishmania Tropica and Leishmania major Isolates
Authors: Ashrafmansouri Marzieh , Sadjjadi Fatemeh Sadat , Seyyedtabaei Seyyedjavad , Haghighi Ali , Rezaei-Tavirani Mostafa , Ahmadi Nayebali 
Published: August 2019

Background: Leishmania major and Leishmania tropica are the main causative agents of cutaneous leishmaniasis. Proteomics as a novel approaches could be used to evaluate protein expression levels in different stages of Leishmania species. We compare the protein contents of amastigote-like forms in L. tropica and L. major using two-dimensional gel electrophoresis (2-DE) and bioinformatics methods. Materials and Methods: Leishmania parasites were isolated from the lesions of Iranian patients and identified using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR). Five isolates of each two species were cultured in specific media to obtain amastigote-like forms to be prepared for proteomics study. Total protein contents were separated using 2-DE. The gels were stained by silver nitrate and scan was imaged. The protein spots with different expression changes in each gel were analyzed using Progenesis SameSpots software. Results: A total of 354 protein spots were detected in both amastigote-like forms. Comparative analysis of protein spots with different expressions in the two amastigote-like form species showed 173 highly expressed spots of which 74 L. tropica and 99 L. major proteins were spotted with fold≥2. Also, 16 and 20 new protein spots were uniquely found in L. tropica and L. major, respectively. Clustering of different detected proteins using correlation analysis divided the proteins into two clusters based on their expression level. Furthermore, clustering results were confirmed by principal component analysis. Conclusion: Using proteomics methods specially 2-DE and statistical analysis demonstrated significant changes in protein expression levels in amastigote-like forms of L. tropica and L. major isolates. [GMJ.2019;8:e1520]
Intraoperative Doppler ultrasound as a means of preventing vertebral artery injury during Goel and Harms C1–C2 posterior arthrodesis: technical note
Authors: Lofrese Giorgio , Cultrera Francesco , Visani Jacopo , Nicassio Nicola , Essayed Walid Ibn , Donati Roberto , Cavallo Michele Alessandro , De Bonis Pasquale 
Published: August 2019

Vertebral artery injury (VAI) is a potential catastrophic complication of Goel and Harms C1–C2 posterior arthrodesis. Meticulous study of preoperative spinal CT angiography together with neuronavigation plays a fundamental role in avoiding VAI. Doppler ultrasonography may be an additional intraoperative tool, providing real-time identification of the vertebral artery (VA) and thus helping its preservation.Thirty-three consecutive patients with unstable odontoid fractures underwent Goel and Harms C1–C2 posterior arthrodesis. Surgery was performed with the aid of lateral fluoroscopic control in 16 cases (control group) that was supplemented by Doppler ultrasonography in 17 cases (Doppler group). Two patients in each group had a C1 ponticulus posticus. In the Doppler group, Doppler probing was performed during lateral subperiosteal muscle dissection, stepwise drilling, and tapping. Blood flow velocity in the V3 segment of the VA was recorded before and after posterior arthrodesis. All patients had a 12-month outpatient follow-up, and outcome was assessed using the Smiley-Webster Pain Scale. Neither VAI nor postoperative neurological impairments were observed in the Doppler group. In the control group, VAIs occurred in the 2 patients with C1 ponticulus posticus. In the Doppler group, 1 patient needed intra- and postoperative blood transfusions, and no difference in terms of Doppler signal or VA blood flow velocity was detected before and after C1–C2 posterior arthrodesis. In the control group, 3 patients needed intra- and postoperative blood transfusions.Useful in supporting fluoroscopy-assisted procedures, intraoperative Doppler may play a significant role even during surgeries in which neuronavigation is used, reducing the chance of a mismatch between the view on the neuronavigation screen and the actual course of the VA in the operative field and supplying the additional data of blood flow velocity.
Presence of a Synergistic Interaction Between Current Cigarette Smoking and Diabetes Mellitus on Development of Dementia in Older Adults
Authors: Noguchi-Shinohara Moeko , Hirako Kohei , Fujiu Makoto , Sagae Masahiko , Samuta Hikaru , Nakamura Hiroyuki , Yamada Masahito 
Published: August 2019

Background: Both cigarette smoking and diabetes mellitus are well-established risk factors for development of dementia. However, the interaction between smoking and diabetes is yet unknown. Objective: In this study, we clarify association between smoking, diabetes, and dementia risk in older adults. Methods: Participants in this study included community residents aged 65 years and older who had participated in a health checkup in 2006, followed for 10 years ( n = 9,403) and had long-term care insurance information data. Furthermore, the risk estimates of smoking status and diabetes diagnosis on dementia adjusted for the competing risk of death prior to dementia were analyzed. Results: During follow-up, 2,647 participants developed dementia. The smoking status–diabetes interaction on development of dementia was statistically significant ( p≤0.001). Among those patients exposed to both factors, 17% of risk of development of dementia was attributable to the interaction of these factors. Current smokers with diabetes had significantly greater risks of development of dementia than never smokers without diabetes (reference): multivariable-adjusted risk of dementia in current smokers without diabetes (subdistribution hazard ratio [sHR], 1.25; 95% confidence interval [CI], 1.05–1.48); never smokers with diabetes (1.31, 1.16–1.47); and current smokers with diabetes (1.86, 1.39–2.48). However, no such association was noted for former smokers with and without diabetes. Conclusions: Current smoking, but not former smoking, was associated with increased risk of development of dementia in older adults with and without diabetes. Moreover, the synergistic effect of current smoking and diabetes on dementia was noted.
An Indoor Therapeutic Garden for Behavioral Symptoms in Alzheimer’s Disease: A Randomized Controlled Trial
Authors: Pedrinolla Anna , Tamburin Stefano , Brasioli Anna , Sollima Alessio , Fonte Cristina , Muti Ettore , Smania Nicola , Schena Federico , Venturelli Massimo 
Published: August 2019

Background: Behavioral and psychological symptoms of dementia (BPSD) affect 60–90% of patients with Alzheimer’s disease (AD). Objective: To determine if environmental therapy is an effective strategy to reduce BPSD, we tested 163 patients with AD with Neuropsychiatric Inventory (NPI) before and after 6 months of an indoor therapeutic garden (TG) or standard environment. Methods: A single-blind randomized controlled trial on AD patients with BPSD. Participants were randomized to an indoor TG (N = 82), or standard environment (control, N = 81) for 6 months. Primary outcome: change in the NPI score from baseline (T0) to end of treatment (T1). Secondary outcomes: change in use of quetiapine, cognition, activities of daily living, salivary cortisol, blood pressure from T0 to T1. Results: NPI score significantly ameliorated (TG versus control: –31.8 points), quetiapine dosage (–150 mg), blood pressure (–2.6 mm Hg), and salivary cortisol (–6.4 to –2.1 Nmol/l) were significantly reduced, the Mini-Mental State Examination significantly improved (1.8 points) in the TG versus control arm at T1 ( p < 0.001). No adverse events were reported. Conclusion: The indoor TG seems safe and may reduce BPSD, medication intake, and cortisol levels in AD.
Targeted Therapies Following First-Line Immune Checkpoint Inhibitor Combination in Metastatic Renal Cell Carcinoma: A Single Center Experience
Authors: Dizman Nazli , Bergerot Paulo G. , Bergerot Cristiane D. , Hsu JoAnn , Pal Sumanta K. 
Published: August 2019

Background: Both late and early phase immune checkpoint inhibitor (CPI) combination trials indicate an impending role of combinations in the first-line treatment of metastatic renal cell carcinoma (mRCC). Sequencing the options following failure of CPI combinations is an emerging conundrum. Objective: To present our single-center clinical experience with targeted therapies (TT) following first-line CPI combinations. Methods: mRCC patients who received TT following failure of a combination regimen with CPI were identified from an institutional database. Clinical information including tumor characteristics, survival outcomes, and adverse events was retrieved from medical records. Descriptive statistics and Kaplan-Meier survival functions were performed. Results: Of 11 patients identified, median age was 63 (31–79) and 8 (73%) patients were male. First-line treatment was a CPI and TT combination in 7 (64%) patients while the rest received combination of two CPIs. The majority of patients (82%) were intermediate risk category at the initiation of targeted therapies. TTs utilized included cabozantinib (46%), lenvatinib and everolimus (27%), sunitinib (18%), and temsirolimus (9%). Best response was stable disease for 10 (91%) and partial response for 1 (9%) patient. In a median follow up of 9.1 months (range, 4.9–34.1), median progression free survival was 7.7 (95% CI 4.6–10.8) months. Progression has occurred in 7 patients, and 3 patients remain on treatment. One patient discontinued treatment due to toxicity. Conclusions: In our report, TTs demonstrate effective disease control and safety. Further exploration in prospective setting is warranted.
Modelling meme adoption pattern on online social networks
Authors: Elsharkawy Sarah , Hassan Ghada , Nabhan Tarek , Roushdy Mohamed 
Published: August 2019

Current research on modelling information diffusion in social media focuses on studying individual information cascades independently. However, as a meme spreads, it evolves, and users adopt the meme in a variety of manners. While individual information cascades can model the propagation of a single piece of information among users, they are not useful in studying the propagation of the whole meme. Modelling the propagation of the whole meme has the ability to describe how users, who adopt the meme, are related to each other, identify who the seed author of the meme is, and recognize the main spreaders of this meme. In this work, we generalize the modelling of independent information cascades to model the diffusion of a meme. We argue that modelling information diffusion as a meme adoption graph (MAG), where each MAG comprises many contributing information cascades, offers a more comprehensive view of the larger scale meme adoption pattern. Hence presents a richer platform to study and monitor the information diffusion pattern of the generalized meme. To construct the MAG that represents the meme diffusion, we first identify messages related to a meme from the social network stream. We utilize a recent clustering algorithm to automatically extract and cluster tweets from the Twitter stream. Next, we evaluate and compare three epidemic models, typically used to construct individual information cascades. We then propose a set of structural characteristics derived from the MAG analysis that describe the underlying meme adoption pattern. Mainly, we focus on the influential spreaders, community formation, and virality measures of the generalized meme. An empirical study, using four real-world Twitter datasets, demonstrates the effectiveness of the proposed MAG. For each dataset, the structural properties of the MAG are derived and compared to the characteristics derived from the independent cascades.
ANALISIS PENDAPATAN ASLI DAERAH (PAD) TERHADAP KEMAMPUAN PEMBIAYAAN KEUANGAN DAERAH KABUPATEN MUSI BANYUASIN
Authors: Asoka Rano 
Published: August 2019

ABSTRACT This study aimed to determine the ability of local revenue (PAD) to the regional finance of Musi Banyuasin Regency. The object of this research is Musi Banyuasin Regency. Data analysis technique used in this research was qualitative analysis technique. The results of this study indicated that the ratio of finance (Decentralization degree) showed that the ability of the original income of the district government of Musi Banyuasin could be said to be not good / independent. It was because the average comparison between Local Own Revenue (PAD) to the Total Revenue District Government of Musi Banyuasin less than 50%. Effectiveness ratio showed that on average from 2010 to 2014 amounted to 103.23%. This could be said to be effective because with the target set was worth more than 100%. With the realization of local revenues on average by 103.23%, the Local Own Revenue (PAD) of Musi Banyuasin Regency based on the ratio of the effectiveness of local revenue was good enough. The degree of Fiscal Autonomy (DOF) of 4.31% with very less criteria. This means that the tendency of the ability of local government of Musi Banyuasin Regency in self-financing activities of government administration, development and service to the community was still very low. Routine Capability Indicators (IKR) of Musi Banyuasin Regency from 2012 to 2014 were up down, on average Index Routine Capability (IKR) was 4.23% with very less criteria. This indicated that the Government of Musi Banyuasin Regency was dependent on the central government