bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of Continuous Ambulatory Peritoneal Dialysis In Remote Area of Southeast Bangladesh
Authors: Hasan Rafiqul , Anwar ASM Tanim , Kabir Muhammad Anwarul , Hakim Mohammad Azizul , Alam Muntasir Ul 
Published: October 2024

Background: Chronic kidney disease (CKD) is a major public health problem that continues to increase in prevalence globally. The prevalence of chronic kidney disease is increasing day by day in low to middle income countries (LMICs). People living in LMICs have the highest need for renal replacement therapy (RRT) despite they have lowest access to various modalities of treatment. As continuous ambulatory peritoneal dialysis (CAPD) does not require advanced technologies, very much infrastructure, dialysis staff support, it should be an ideal form of RRT in LMICs, particularly for those living in remote areas. To authors knowledge there was scarcity of data regarding CAPD performance in remote area of Bangladesh. This study was aimed to report the characteristics and outcomes of CAPD in ESRD patients lived in least developed area of Bangladesh.
Methods: This prospective study was conducted in Cox’sbazar Medical College Hospital, Cox’sbazar and Parkview hospital Ltd, Chattogram, Bangladesh. Data were collected by questionnaire from the patients of any age with end-stage renal disease (ESRD) who underwent CAPD in 2018–2021. The baseline characteristics, PD-related complication as well as patient and technique survivals were analyzed.
Results: Out of 31 patients who underwent CAPD, 18 (58%) were male on the age range of 15–79 years. The mean follow-up duration was 18 months. Mortality was inversely related with the EF of echocardiography. The peritonitis rate was 0.48 episodes per patient per year. The 1, 3 and 4-year patient survival rates were 64.34% (95% CI = 52.5–81.5), 23.79% (95% CI = 17.9 – 57.4) and 3.22% (95% CI = 31.2–77.5) respectively.
Conclusions: In this study, CAPD performance was poorer than usual reference. Cardiac compromised patient and inappropriate dwell might be the main contributing factors behind this scenario. The peritonitis rate was nearly similar to that of developed countries. CAPD was cost effective than HD in remote area. Some accessible measures may be taken to make CAPD a more acceptable RRT modality with improved outcomes in poor socioeconomic backgrounds area.
J Dhaka Med Coll. 2023; 32(1) : 24-31
Efficacy of Autologous Platelet Rich Plasma For Treatment of Diabetic Foot Ulcer
Authors: Sakib Md Nazmus , Haque A K M Lutful , Adneen Zannatu , Das Prosunto Kumar , Dewan Nayeem , Alam A B M Khurshid , Hossain Sonia 
Published: October 2024

Background: Diabetic foot ulcer (DFU) is a common complication of long standing uncontrolled diabetes mellitus. There are different types of treatment commonly practiced among the clinicians to treat DFU. Among them, autologous platelet rich plasma (PRP) application is getting popularity day by day throughout the western world.
Methodology: It was a prospective, randomized, controlled study that was carried out among 40 DFU patients in the Department of Surgery, Dhaka Medical College Hospital. Among them, 20 patients were treated by autologous PRP and another 20 patients were treated by conventional method. They were followed up for 12 weeks period. Data collected from the participants were analyzed to compare the healing rate among two groups.
Result: In PRP treated ulcers, healing rate was significantly faster and better in comparison to conventionally treated ulcers. After 10th weeks follow up, in PRP group 14 ulcers were completely healed whereas in control group,4 ulcers were completely healed. On the contrary, 3 ulcers in control group showed further deterioration. At the end of 12th weeks follow up, 19 ulcers in PRP group were completely healed whereas 13 ulcers in control group were completely healed. In PRP group no patient showed any complication during treatment, whereas in control group 7 patients experienced local complications.
Conclusion: Treatment of diabetic foot ulcer with autologous platelet rich plasma results in faster and better ulcer healing in comparison to conventional treatment. PRP accelerates the healing rate and keep the ulcer area safe from external pathogens. Hence, autologous PRP is a better selection for DFU treatment.
J Dhaka Med Coll. 2023; 32(1) : 38-42
Clinical Profile And Aetiology of Acute Kidney Injury Developing In Patients Hospitalized Due To Non-Renal Cause With Pre-Existing Normal Renal Function
Authors: Akter Sanzida , Kamal Mohammad Mostafa 
Published: October 2024

Background: Acute kidney injury (AKI) is a common complication in patients hospitalized for non-kidney disease and having normal renal function. Early detection of development of deteriorating renal function and assessment of its cause can help to manage the cases effectively and can prevent further kidney damage or progression to end stage renal failure.
Methods: This observational study was done on 50 patients selected from the departments of Medicine and Nephrology of Dhaka Medical College (DMCH) and BSMMU, from June 2012 to November 2012. Patients were included in the study who developed clinical features and biochemical findings of acute kidney injury, while being admitted with various non-renal diseases and had previous normal renal function.
Results: In this study the cause of deterioration of renal function was Sepsis in 44.0% of the patients, 42.0% had fluid loss, 6.0% had used nephrotoxic drugs, 4.0% had hepatitis, 2.0% patients each had pancreatitis and insect bite respectively. 40% of the patients were above 40 years of age, 54% were male. Vomiting was present in 42% of the patients and diarrhoea in 20% of the patients. 26% patients had DM and 22% had hypertension.
Conclusion: Sepsis and hypovolemia were the common causes of developing acute kidney injury in the hospital. In-hospital mortality was 18.0% and 22.0% patients developed CKD after three months follow-up.
J Dhaka Med Coll. 2023; 32(1) : 85-91
Full Endoscopic Decompression for Single Level Lumbar Stenosis: A Clinical Evaluation
Authors: Mohammad Nuruzzaman Khan  , Shuvro Saha  , Sabrina Shafiq  , Avijit Dey  , A M M Mukarrabin  
Published: October 2024

Objective: This study aimed to evaluate the outcomes of full endoscopic decompression for single level lumbar spinal canal stenosis.
Methods:This observational study was conducted on a total of 370 patients selected by purposive sampling from January 2022 and December 2023, presenting with symptoms more than 3 months and non-responding to conservative treatment. The procedure was performed by placing the patient on a radiolucent Wilson frame with single-shot epidural analgesia. Outcome was measured in terms of pain reduction using Visual analog scale (VAS) before and after surgery, at 3rd, 6th month, and functional outcome was assessed using the Modified MacNab criteria at 6th month,
Results: The mean age of the patients was 56.1 years, with 63% male. The most common stenosis level was L4-L5 (36.5%). The mean operation duration was 53 minutes, and the postoperative complications were minimal. Significant improvement in pain levels was observed, with back pain reduced from a preoperative mean of 3.2 to 1.1 at six months, and leg pain from 7.2 to 1.0 (p < 0.001). According to the Modified MacNab criteria, 91.1% of patients reported excellent outcomes at six months, and 8.4% reported good outcomes.
Conclusion: Full endoscopic decompression is a highly effective and safe method for treating lumbar spinal stenosis, providing substantial pain relief and excellent functional outcomes with minimal complications.
J Shaheed Suhrawardy Med Coll 2023; 15(1): 3-7
Comparative Study of Olmesartan versus Telmisartan, in Patient with Stage I Hypertension
Authors: Md Murshidur Rahman Khan  , Md Moshfequre Rahman  , Abdur Rahman  , Md Akteruz Zaman  , Udoy Shankar Roy  
Published: October 2024

Background: Hypertension is one of the most common diseases in the world. It is defined as sustained increase in blood pressure ≥ 140/90 mmHg. The risk of both microvascular & microvascular complications including stroke, coronary artery disease, peripheral vascular disease, retinopathy, nephropathy & possibly neuropathy increases with hypertension. Olmesartan medoxomil is a non-peptide angiotensin II receptor antagonist. The drug acts by selectively blocking angiotensin II type 1 receptor. Telmisartan is angiotensin receptor blocker shows high affinity for the angiotensin II type 1 receptors. Objective of the study is to compare the efficacy of Olmesartan and Telmisartan in Patient with stage –I hypertension. Materials and methods: This was a randomized, open‑label, parallel‑group, comparative study conducted in 120 patients of Stage I hypertension carried out from January 2021to June 2022. Patients were recruited from the cardiology outpatient department (OPD) of Shaheed Suhrawardy Medical College hospital.Results: In olmesartan group there were 39 male and 21 female patients and in telmisartan group there were 36 male and 24 female patients. Both Olmesartan and Telmisartan are effective in lowering systolic & diastolic BP at different intervals of 2nd, 4th, 8th and 12th week. There was a statistically significant decrease in mean blood glucose level after 12 weeks of treatment in telmisartan group when compared to baseline. Serum total cholesterol, triglycerides, and low‑density lipoproteins decreased significantly after 12‑week treatment with olmesartan and telmisartan. Conclusion: Olmesartan and telmisartan are equally efficacious in reducing DBP. Olmesartan, when compared to telmisartan is more efficacious in reducing SBP. Whereas Telmisartan shows the most favorable effects on FBG and lipid profile.
J Shaheed Suhrawardy Med Coll 2023; 15(1): 8-12
Prevalence and Determinants of Vitamin D Deficiency during the First Trimester: Evidence from a Major Metropolitan City in Bangladesh
Authors: Fahmida Shirin  , Nahid Sultana  , Faisal Chowdhury  , Fahmida Islam Chowdhury  , Munawar Sultana  , Jannatul Ferdous  , Shahnaj Jahan Chawdhury  , Asifa Ali  , Koushik Deb  
Published: October 2024

Introduction: Vitamin D deficiency in early trimesters can have detrimental effect on feto-maternal outcomes. This research aimed to determine the prevalence and possible associated factors with vitamin D deficiency during first trimester in Chattogram city, Bangladesh.
Methods: This was a cross-sectional study conducted from July to September, 2023 in Chattogram metropolitan city with purposive sampling. After obtaining consent a questionnaire was provided and blood was drawn for biochemical analysis. Statistical inference was done through SPSS V25.
Results: Total 398 women participated in this study with mean age of 27 years. More than half (51.8%) were suffering subpar vitamin D level, with 15.1% being deficient and 36.7% having insufficient vitamin D level. Most participants were housewives (78.6%) with over half (57.5%) completing their undergraduate degree. Private service (40.5%) was the most prevalent spouse’s profession. Most of the women were primigravid (41.2%). 34.4% and 34.4% of participants had one instance of cesarean section and abortion respectively. High prevalence of anemia was present (49.2%) and was statistically significant with subpar vitamin D level (p<0.05). Husband’s occupation and covered clothing style was also found to be statistically significant.
Conclusion: There is significant prevalence of vitamin D deficiency in early pregnancy in Chattogram metropolitan region. Further research and early intervention should be implemented to prevent and mitigate this deficiency and prevent associated adversities.
J Shaheed Suhrawardy Med Coll 2023; 15(1): 39-44
Prognostic Significance of Angiogenesis in invasive ductal carcinoma
Authors: Monika Mehjabin  , Abdus Sabur Talukder  , Sabera sultana  , Nure Jannat Ferdousi  , Umme Kulsum Munmun  , Mohammed Kamal  
Published: October 2024

Background: Angiogenesis is essential for tumor growth and metastasis. Axillary lymphnode status has been the most important prognostic factor in operable breast carcinoma, but it does not fully account for the varied disease outcome. More accurate prognostic indicators would help in selection of patients at high risk for disease recurrence and death who are candidates for systemic adjuvant therapy. Microvessel density in invasive ductal carcinoma (measures of tumor angiogenesis) is associated with metastasis and thus may be a prognostic indicator. Objective: To correlate intratumoral and peritumoral angiogenic microvessel density with lymphnode metastasis in invasive ductal carcinoma. Material and Methods: It is a cross sectional observational study, carried out at the department of Pathology, BSMMU from January 2016 to December 2017. A total 48 mastectomy samples with axillary nodes from histologically confirmed invasive ductal carcinoma were included in this study. Weidner method was used for calculating micro vessels density. Sections examined to evaluate the density of angiogenic vessels by immuohistological stain with vWF expression in invasive breast cancer. Correlation between angiogenic vessels density with or without lymphnode metastasis was taken. Results: In this study angiogenic vessel count is more in the intratumoral area than peritumoural area. There was a positive significant correlation between lymphnode metastasis with micro vessel density in both peritumoral and intratumoral areas in Weidner method in vWF stain.
J Shaheed Suhrawardy Med Coll 2023; 15(1): 59-65
КОНДИЦІЙНЕ ТРЕНУВАННЯ КІБЕРСПОРТСМЕНІВ З ВИКОРИСТАННЯМ МОБІЛЬНИХ ДОДАТКІВ
Authors: Єфременко Андрій , Пятисоцька Світлана , Подрігало Леонід 
Published: October 2024

The issue of insufficient physical activity among computer game players remains relevant. This study proposes a solution based on the comprehensive use of gaming-oriented mobile applications for the conditioning training of esports athletes. A sequential pedagogical experiment was conducted to determine the effectiveness of esports athletes applying an aerobic-focused conditioning training program (slow running). The program’s unique feature is its implementation in a remote format using mobile applications for planning, execution, control, and performance evaluation. It is based on an original concept of implementing running training in the form of a mobile running application (the so-called “exergame”) with a game-like nature (“Zombies, Run!”). The program was designed for a six-week implementation. Its effectiveness was determined by evaluating the dynamics of indicators: 1600 m run time; calculated maximal oxygen consumption (VO2 max); and heart rate (HR). Subjective attitudes towards the program’s physical loads were assessed using the Rating of Perceived Exertion (RPE) scale and the Physical Activity Satisfaction Needs scale. It was found that esports athletes significantly (p<0.05) improved their 1600 m run time, VO2 max, and HR indicators under the influence of the slow running program. Along with the volume and intensity increase of the running load, a decrease in RPE scale indicators was observed. The obtained data confirmed the advantages of the comprehensive use of mobile applications for normalizing the motor activity of esports athletes in the form of conditioning training. Both the remote format of planning and accounting and the game format of activities contributed to increasing the engagement of esports athletes in physical activity. The effectiveness of the slow running training program for esports athletes using mobile applications was established in terms of increasing physical activity (regular, organized physical activity), improving physical fitness (duration and volume of slow running), enhancing physical condition (VO2 max, HR), and interest in physical activity (adherence).
Predicting an opaque bubble layer during small-incision lenticule extraction surgery based on deep learning
Authors: Zhu Zeyu , Zhang Xiang , Wang Qing , Xiong Jian , Xu Jingjing , Yu Kang , Guo Zheliang , Xu Shaoyang , Wang Mingyan , Yu Yifeng 
Published: October 2024

AimThis study aimed to predict the formation of OBL during femtosecond laser SMILE surgery by employing deep learning technology.MethodsThis was a cross-sectional, retrospective study conducted at a university hospital. Surgical videos were randomly divided into a training (3,271 patches, 73.64%), validation (704 patches, 15.85%), and internal verification set (467 patches, 10.51%). An artificial intelligence (AI) model was developed using a SENet-based residual regression deep neural network. Model performance was assessed using the mean absolute error (EMA), Pearson’s correlation coefficient (r), and determination coefficient (R2).ResultsFour distinct types of deep neural network models were established. The modified deep residual neural network prediction model with channel attention built on the PyTorch framework demonstrated the best predictive performance. The predicted OBL area values correlated well with the Photoshop-based measurements (EMA = 0.253, r = 0.831, R2 = 0.676). The ResNet (EMA = 0.259, r = 0.798, R2 = 0.631) and Vgg19 models (EMA = 0.31, r = 0.758, R2 = 0.559) both displayed satisfactory predictive performance, while the U-net model (EMA = 0.605, r = 0.331, R2 = 0.171) performed poorest.ConclusionWe used a panoramic corneal image obtained before the SMILE laser scan to create a unique deep residual neural network prediction model to predict OBL formation during SMILE surgery. This model demonstrated exceptional predictive power, suggesting its clinical applicability across a broad field.
Clinical efficacy and mechanism of the combination of autologous platelet-rich gel and recombinant human acidic fibroblast growth factor in the management of refractory diabetic foot
Authors: Sheng Xia , Hu Ling , Li Ting , Zou Yi , Fu Hai-Yan , Xiong Guo-Ping , Zhu Yan , Deng Bo , Xiong Lei-Lei , Yin Xiao-Ling 
Published: October 2024

ObjectiveThis study aims to explore the influence of combining autologous platelet-rich gel (APG) with continuous vacuum-sealed drainage (CVSD) and the exogenous recombinant human acidic fibroblast growth factor (rh-aFGF) on the healing processes of diabetic foot ulcers (DFU). The primary objective is to elucidate the complex molecular mechanisms associated with DFU, providing innovative perspectives for its treatment.MethodsNinety patients diagnosed with DFU were randomly allocated into three distinct groups. Group A underwent CVSD following wound cleansing to facilitate healing. In Group B, in addition to conventional treatment, negative pressure wound therapy was applied, and rh-aFGF was introduced into normal saline for lavage, building upon the procedures of Group A. Group C received APG along with the interventions applied in Group B. The clinical efficacy of each group was systematically observed and analyzed. Additionally, changes in plasma oxidative stress, inflammatory markers, vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) were assessed both before treatment and 14 days post-treatment.ResultsFollowing treatment, all groups exhibited commendable clinical efficacy. Group C demonstrated a superior wound healing rate, reduced frequency of dressing changes, and shorter wound healing duration (P&lt; 0.05). Compared to baseline measurements, the levels of superoxide dismutase and PEDF increased, while malondialdehyde, VEGF, interleukin-6, interleukin-8, and monocyte chemotactic factor MCP-1 decreased in the wound tissue across all groups. Notably, Group C showed the most significant improvement in clinical efficacy and fortification of molecular mechanisms against oxidative stress (all P&lt; 0.05).ConclusionsThe integrative therapeutic approach combining APG with CVSD and rh-aFGF demonstrates notable efficacy in advancing wound healing. This effectiveness is evident through the reduced frequency of dressing changes and alleviation of wound-related pain. Additionally, the treatment regimen improves the cure rate for challenging, refractory wounds. These favorable outcomes can be attributed to the reduction of oxidative stress levels, attenuation of the local inflammatory response, and the enhancement of the balance between PEDF and VEGF.
A guideline on biomarkers in the diagnosis and evaluation in axial spondyloarthritis
Authors: Liu Dong , Xie Ya , Tu Liudan , Wen Xianghui , Lv Qing , Liu Budian , Yang Mingcan , Wu Xinyu , Zheng Xuqi , Luo Xiqing , Zhou Liuzhong , Wu Jialing , Liu Bin , Wang Kun , Jin Ou , Wang Xiaohong , Qin Jie , Wu Lijun , Zhao Dongbao , He Dongyi , He Shanzhi , Huang Wenhui , Ye Shanhui , Zhou Huiqiong , Wu Jinyu , Wang Yongfu , Liu Shengyun , Li Zhenbin , Tan Zhiming , Xu Chiduo , Wang Youlian , Zheng Donghui , Zhan Feng , Lin Changsong , Wen Ya , Wu Jiayun , Wen Shenghui , Liao Zetao , Shen Yan , Yang Kehu , Gu Jieruo 
Published: October 2024

ObjectiveTo develop a guideline for selecting biomarkers in the diagnosis and assessment in patients with axial spondyloarthritis (axSpA).MethodA joint effort was carried out by the core team, the literature review team and the multidisciplinary voting panel to formulate recommendations regarding biomarkers in axSpA, using an evidence-based and consensus-based strategy. Certainty of evidence and strength of recommendation were determined, and levels of agreement within the voting panel were calculated.ResultsA total of 20 recommendations were formulated in this guideline, with levels of agreement ranging from 6.48 to 9.71. The two strong recommendations, HLA-B27 testing in patients suspected of axSpA and regular-interval monitoring of CRP/ESR represent the status quo of axSpA evaluation, while the 13 conditional recommendations represent the promising biomarkers with clinical utility in diagnosis, disease activity assessment, prediction of radiographic progression and therapeutic responses. This guideline does not dictate clinical choices of tests on axSpA, and decisions should be made based on comprehensive consideration of costs, accessibility, patients’ values and willingness as well as the objective of testing in the local context.ConclusionThis guideline addresses the interpretation of the clinical significance of biomarkers in axSpA, and the biomarkers endorsed in this guideline composed a clinical toolkit for healthcare professionals to choose from.