bluuebunny/crossref_metadata_2025_split huggingface dataset:
EML4-ALK Rearrangement and Its Therapeutic Implications in Inflammatory Myofibroblastic Tumors
Authors: Vargas-Madueno Fernando , Gould Edwin , Valor Raul , Ngo Nhu , Zhang Linsheng , Villalona-Calero Miguel A. 
Published: May 2018

Abstract

With the advent of precision medicine, medical oncology is undergoing a transcendental change. These molecular studies have allowed us to learn about potential targeted therapies for patients with advanced cancers. Perhaps the best-known example of success in precision medicine is chronic myeloid leukemia and its response to tyrosine kinase inhibitors targeting the BCR-ABL kinase. Since that original discovery, the role of molecular therapeutics has expanded, and it now presents us with treatment options for common malignancies and rare atypical tumors. In this article, we present a case of a 61-year-old female with a recurrent pulmonary inflammatory myofibroblastic tumor. Subsequent molecular studies revealed an ALK rearrangement. The significance of this alteration in this tumor type and its therapeutic implications are discussed herein.

Key Points
This case exemplifies the heterogeneous behavior of inflammatory myofibroblastic tumors (IMTs) and the current role of targeted therapy in the therapeutic armamentarium of neoplastic processes. As evidenced by the different mutations found in IMTs, it is of great importance to perform next-generation sequencing in uncommon neoplasms. These studies can find different potential targets and therapeutic options for patients devoid of standard effective therapies.
Comparative study of temporalis fascia graft versus cartilage shield tympanoplasty
Authors: Chhabra Gaurav , Saxena Amresh K. , Kumar Sanjay 
Published: May 2018

<p class="abstract"><strong>Background:</strong> The objective of the study was to demonstrate the comparative study in terms of graft uptake rate &amp; hearing gain between cartilage shield tympanoplasty and temporalis fascia tympanoplasty in patients with moderate/ large/subtotal perforation.</p><p class="abstract"><strong>Methods:</strong> Cartilage shield tympanoplasty and temporalis fascia tympanoplasty were conducted in Group A and Group B, respectively, each containing 30 patients with moderate/large/subtotal perforations. Pure tone audiogram (PTA) was performed preoperatively and at postoperative visit i.e. at 12<sup>th</sup> month, a greater than 10-dB closure of air bone gap (ABG) was considered significant. </p><p class="abstract"><strong>Results:</strong> The graft uptake rates were 93.33% and 86.67% in Group A and Group B, respectively, at the end of 10th week. In total, 90% in Group A and 88% in Group B had significant improvement in hearing (ABG ≥10 dB) at 12th week of surgery.</p><p class="abstract"><strong>Conclusions:</strong> Conchal cartilage is a possible graft material for cartilage shield tympanoplasty, especially in moderate, large &amp; subtotal perforation, as it is showed superior autograft as compared to temporalis fascia, not only because of better graft uptake rate and less partial failure but also due to the comparable hearing improvement in terms of mean AB gap in both types of graft materials.</p>
Key Management Model Of Added Value In The Historical Tourist Attractions: The Case Studies The Emerald Buddha Temple Bangkok Thailand
Authors: Kerdpitak Chayanan 
Published: May 2018

The promotion of the historical tourist attractions is an important mission that should be accomplished to ensure that the tourists have admired ancient sites that are valuable, rare, Inimitable andnon – substitution. The tourists are thus enthusiastic to visit the ancient sites and willing to promote and encourage other tourists to visit these tourist attractions. By this reason, the objective of this research is to study the main factors affecting the added value of the tourist to the historical tourist attractions in Thailand. The factors include, Participation Management, Processes Management, Resource Management, Tourists Satisfaction, Tourist Attractions Differentiation and Added Value of Tourists.
In this study, the researcher has applied both quantitative and qualitative research methodologies using questionnaires and in-depth interview. The sample comprises visitors to the Temple of the Emerald Buddha. Meanwhile, the path analysis has been used to analyze the data. At the same time the researcher intends to propose the conceptual framework for this study with an aim to identify of the research question, there are any factors affecting to the added value of the visitors to the ancient sites. Moreover, the researcher has recommended 7 assumptions to find out the factors that have effects on the added value of the visitors to the ancient sites.
The result has shown that the Tourists satisfaction and the differentiation in tourist attractions have affected the visitors’ added value with the significance level at 0.008. The result of this study can be used to set up the business operations policy of the Thai tourism business. The policy focuses on differentiation placing the development of tourist attractions as first priority followed by the environmental management, the promotion of tourist attractions and the renovation of ancient sites respectively.
Gambaran Kondisi Ibu Hamil dengan Diabetes Mellitus di RSD dr. Soebandi Jember Tahun 2013-2017 (Description of Pregnant Women Condition with Diabetes Mellitus in RSD dr. Soebandi Jember on 2013-2017)
Authors: Tito Putri Meggeria Dyah Matrika , Wahjudi Pudjo , Prasetyowati Irma 
Published: May 2018

Abstract
Diabetes Mellitus or diabetes is a chronic metabolic disease disorder caused by pancreas does not produce enough insulin or the body can’t effectively use produced insulin. In pregnant women with a family history of diabetes mellitus, the prevalence of pregnancy with diabetes mellitus is 5.1%. This research aim to determine description of pregnant women condition with diabetes mellitus in RSD dr. Soebandi Jember. This research used descriptive method with case series design. The sample size of 19 pregnant women with diabetes mellitus was selected by total sampling technique. The results showed that the high maternal age (52.6%), low education (89.5%), unemployment or housewife (89.2%), had a genetic 78.9%), BMI overweight (57.9%), glucosuria (89.5%), history of pre-eclampsia (57.9%), low parity (79%), never miscarried (84.2%). Based on the result of the research, it was concluded that maternal education, maternal job, genetic, overweight BMI, glucosuria, and history of pre-eclampsia had an effect towards the occurrence of pregnant women with diabetes mellitus, also maternal age, parity and history of miscarriage had no effect on the occurrence of pregnant women with diabetes mellitus. To raise awareness of the risks of pregnancy with diabetes mellitus can be done with screening for diabetes mellitus.
Keywords: diabetes mellitus, pregnant women, RSD dr. Soebandi.
Status Gizi dan Kualitas Hidup Lansia yang Tinggal Bersama Keluarga dan pelayanan Sosial Tresna werdha (Nutritional Status and Quality of Life of Elderly People Who’s Lived With Family and Tresna Werdha Social Service in Bondowoso)
Authors: Lailiyah Putri Istik , Rohmawati Ninna , Sulistiyani Sulistiyani 
Published: May 2018

Abstract
The number of population and life expectancy of elderly in Indonesia have increased every year. Health problems of elderly are associated with the environmental change and nutritional status that will affect for their quality of life. This research used a cross sectional approach and conducted in Bondowoso area with data at Tresna Werdha Social Service Bondowoso and elderly living in region of Maesan Public Health Centre. This research based on 72 respondents, consist of 36 respondents that living with family and 36 respondents that living in PSTW. The sampling technique used Proportional Random Sampling. Methods of data used questionnaires adapted from WHOQOL-BREF. Data analyzed by Chi Square test (α = 0,05). The results showed that nutritional status of elderly living in PSTW were better than elderly living with their family (p<0,05). Quality of life according of physical health domain, psychological domain, social relationships domain, and over all quality of life of elderly living with their family were better than the elderly living in PSTW (p <0.05). While on quality of life according to environment domain in elderly living with their family and PSTW have same result (p> 0,05).
Keywords: elderly,nutritional status, quality of life
Natural Fractures and Mechanical Properties in a Horn River Shale Core From Well Logs and Hardness Measurements
Authors: Yang Sheng , Harris Nicholas B. , Dong Tian , Wu Wei , Chen Zhangxin 
Published: May 2018

Summary
This paper documents the formation of natural fractures in the Horn River Group, a major Canadian shale gas play, and addresses relationships between natural-fracture development and rock-mechanical properties derived from cores and well logs. Most natural fractures in the Horn River Shale are narrow vertical fractures, sealed with carbonate minerals. In this study, the formation of observed fractures is primarily determined by a lithology type, mineral composition, and rock-mechanical properties at the timing of fracturing.
Brittleness is an important geomechanical property controlling the formation of fractures, because brittle shale is more easily fractured than ductile shale, and fractures in brittle shale tend to persist when the fracturing pressure is released. In this study, a hardness value measured by a commercial hardness tester is found to be a good proxy for the brittleness of shale layers. On the basis of a statistical analysis, the threshold values of both hardness and brittleness are estimated to predict the distribution of natural fractures, assuming that the mechanical properties of the host rock were relatively stable from at least the time at which fractures formed. Hardness values are shown to be more reliable than brittleness.
A Perforation-Erosion Model for Hydraulic-Fracturing Applications
Authors: Long Gongbo , Liu Songxia , Xu Guanshui , Wong Sau-Wai , Chen Hanxin , Xiao Boqi 
Published: May 2018

Summary
Perforation pressure drop and its decrease caused by perforation erosion during a hydraulic-fracturing treatment are critical factors that need to be considered in treatment design, particularly when the limited-entry technique is implemented along multiple perforation clusters to ensure more-uniform fluid distribution. The simultaneous increases in the discharge coefficient Cd and perforation diameter D during perforation erosion require consideration of the temporal changes of these two variables to characterize the perforation-erosion behavior. In this paper, we present a perforation-erosion model dependent on abrasion mechanisms and the procedure to determine the specific erosion parameters that can be corroborated from laboratory data. Our modeling results demonstrate that it is inappropriate to assume an alternate increase in Cd and D, as considered in some conventional correlations. Once the erosion parameters are empirically inferred, we incorporate our model into a nonplanar hydraulic-fracturing simulator to determine appropriate perforation-number distributions at different clusters to ensure a successful limited-entry treatment that generates relatively even fluid distribution and uniform fractures.
Partition-Coefficient Relations for Improved Equation-of-State Description of Microemulsion-Phase Behavior
Authors: Torrealba Victor A. , Johns Russell T. 
Published: May 2018

SummarySurfactant-mediated enhanced-oil-recovery (EOR) techniques, such as surfactant/polymer (SP) flooding, have received increased attention because of their ability to reduce capillary forces at the pore-scale to ultralow values and mobilize trapped oil. Recently, there have been increased efforts in microemulsion-phase-behavior modeling capabilities by relying on the hydrophilic/lipophilic-difference (HLD) measure for surfactant-affinity quantification. One common assumption of most microemulsion-phase-behavior models is the assumption of pure excess phases, which states that the surfactant component is only present in the microemulsion phase. This assumption can lead to significant errors for some surfactant systems, especially when applied to chemical simulations in which discontinuities may arise.The main novelty of this paper is to allow for surfactant partitioning into both the water and oil excess phases by use of a simple approach, and then relate relevant surfactant-partitioning coefficients (i.e., K-values) to HLD. Surfactant screening that is based on surfactant-structure parameters is also considered based on estimated K-values. Key dimensionless groups are identified as a function of activity coefficients, which allow for a simplified description of the surfactant-partition coefficients. These surfactant-partition coefficients are combined with the chemical-potentials (CP) equation-of-state (EoS) model to describe and predict the phase behavior when the excess phases are not pure. Further, the developed surfactant-partitioning model can be used in other microemulsion-phase-behavior models to allow for impure excess phases.
A Newly Developed Wellbore-Simulation Apparatus To Study Performance of Oilwell Cements
Authors: Li Zichang , Vandenbossche Julie M. , Janssen Donald J. , Iannacchione Anthony T. 
Published: May 2018

Summary
Research has been dedicated to the development of laboratory-scale simulation devices for studying mechanisms of gas migration. Cement-hydration analyzers (CHAs) are commercially available to assist industry in the design of gas-tight slurries. Although cement slurries under controlled conditions in the laboratory can be gas-tight, the in-situ performance of cement slurries is highly variable and difficult to predict. Therefore, a new approach has been designed to evaluate gas-migration potential under a range of representative borehole conditions. A laboratory-scale wellbore-simulation chamber (WSC) has been developed to replicate hydrostatic-pressure reduction in the cemented annulus and evaluate the potential for gas invasion under a range of borehole conditions. A discussion is presented on the development of the WSC that includes the details of the design and monitoring systems as well as the performance characteristics. Calibration-test results are examined to evaluate the performance of the WSC and the ability of the WSC to simulate in-situ wellbore conditions. Analysis of the results verifies the capability of the WSC in successfully recording the necessary parameters.
Improved removal performance and mechanism investigation of papermaking wastewater treatment using manganese enhanced Fenton reaction
Authors: Wang Yingcai , Wang Can , Shi Shuai , Fang Shuai 
Published: May 2018

AbstractThe effects of Mn(II) on Fenton system to treat papermaking wastewater and the mechanism of Mn(II) enhanced Fenton reaction were investigated in this study. The chemical oxygen demand (COD) removal efficiency was enhanced in the presence of Mn(II), which increased by 19% compared with that of the Fenton system alone. The pseudo-first order reaction kinetic rate constant of Mn(II)/Fenton system was 2.11 times higher than that of Fenton system. 67%–81% COD were removed with the increasing Mn(II) concentration from 0 to 0.8 g/L. COD removal efficiency was also enhanced in a wider pH range (3–7), which indicated the operation parameters of Fenton technology could be broadened to a milder condition. The study of the mechanism showed that Mn(II) participated in the oxidation and coagulation stages in Fenton system. In the oxidation stage, Mn(II) promotes the production of HO2•/ O2•−, then HO2•/ O2•− reacts with Fe(III) to accelerate the formation of Fe(II), and finally accelerates the production of HO•. Meantime MnMnO3 and Fe(OH)3 forms in the coagulation stage, facilitating the removal of suspended substances and a large amount of COD, which enhances the overall COD removal of papermaking wastewater. This study provided a detailed mechanism to improve practical applications of Fenton technology.
The Complications of Bariatric Surgery Patients with Type 2 Diabetes in the World: A Systematic Review and Meta-Analysis
Authors: Kabir Ali , Mousavi Sara , Pazouki Abdolreza 
Published: May 2018

Background:
In this Meta-analysis, we aimed to quantify the incidence of complications of
different methods of bariatric surgery on diabetic patients.

Introduction:
Type 2 Diabetes Mellitus (T2DM) is increasing worldwide specifically in obese cases.
Additionally, obesity worsens T2DM. Complications of each bariatric surgery method were assessed
separately; but, a meta-analysis of these complications and comparison between procedures in T2DM
patients have not been investigated previously. The result of this study will help surgeons to choose the
most appropriate surgical technique, considering individual conditions for a diabetic patient.

Methods:
We searched PubMed, Scopus, and ISI for original papers including bariatric surgical procedures
for diabetic population and the reported consequences. Data analyses were done using Stata software.

Results:
Mortality percentage between diabetic and non-diabetic patients was statistically nonsignificant
(P = 0.987). Early and late complications were higher in diabetic group in comparison with
non-diabetic (6.0% vs. 1.8%, P = 0.024 and 0.6% vs. 0.3%, P = 0.04, respectively). Most prevalent
findings in malabsorptive (7.8%, P < 0.001) and restrictive procedures (80%, P < 0.001) were major
complications and hypoglycemic episodes, respectively.

Conclusion:
As our study showed, most of the complications are not necessarily higher in diabetic
population but dependent on the method of surgery.
Thermally Activated Magnetic Switching Mode for Various Thicknesses of Perpendicularly Ferromagnetic Nano-dot
Authors: Wibowo Nur A. , Handoyo Cahya , Sasongko Leopoldus R. 
Published: May 2018

Background:Even applying thermal pulse has been succeeded to reduce the coercivity through randomization the magnetization in such a way stimulate the magnetic reversion, the efficiency of magnetic switching field consumption in writing process still turns out to be an exciting research field to implement the HAMR technology. One of the remarkable geometric properties of HAMR storage media that can be correlated to the writing field reduction issue is the nano-dot thickness. Furthermore, thermal fluctuation causes the magnetization switching process to be probabilistic. This magnetic switching probability determines the magnitude of the writing field. This paper aims to investigate the impact of changes in media thickness on the magnetization process in particular at high temperatures numerically.Methods:Nano-dot was modeled as a parallelepiped with uniaxial anisotropy which was regarded as a magnetically isolated system where no disturbance field of neighboring nano-dots. Simulation arrangements were implemented to evaluate the two viewpoints in the current heat-assisted magnetic recording, either coercivity, as well as writing field consume. Coercivity was gauged by inducing a magnetic field which linearly increased up to 2 Tesla for 2.5 ns at thermal equilibrium to the surrounding. In evaluating writing field consume, thermal field pulse which just below the Curie temperature was generated while the magnetic field inducing the nano-dot. These schemes investigations were based on the Landau-Lifshift- Gilbert equation which accommodates the fluctuation-dissipation theorem in calculating thermal fluctuation effect. Also, temperature dependent material parameters such as magnetic saturation, magnetic anisotropy, and exchange interaction, were taken into account.Results:At room temperature, the coercive and nucleation fields are highly sensitive to the nano-dot thickness. Under thermal assistance, the writing field for 10 nm and 100 nm of the chosen thicknesses are 0.110 T and 0.125 T respectively. These writing grades are significantly lower than the coercivity of the media. For both thicknesses, zero field magnetization reversal phenomena are observed as indicated by the existences of the switching probabilities at H = 0.Conclusion:This numerical study showed that using the heating assistance close to the Curie point, nanodots with the chosen thicknesses and magnetic parameters were probably to be magnetized even no driven magnetic field. Along with this result, magnetic field induction which required to utterly magnetizing was only in the sub-Tesla - about a tenth of the coercive field. During magnetization processes under thermal assistance, randomization of magnetic moments initiated the switching dynamic before the domain wall was nucleated and propagated to reach a single magnetized domain.
A FORMAÇÃO COMO PEDAGOGIA DA RELAÇÃO
Authors: Formosinho Júlia Oliveira , Formosinho João 
Published: May 2018

Este artigo apresenta a interatividade entre a pedagogia da infância e a pedagogia da formação de professores de educação infantil, focando-se nas perspetivas participativas para formar adultos e educar crianças. Comparam-se os papéis da mediação pedagógica ao nível da formação inicial e da formação em contexto ouvindo os atores centrais – formandos e formadores. Apresenta-se toda a formação como uma pedagogia da relação no âmbito de uma teoria do desenvolvimento humano.
MODERNIDADE PEDAGÓGICA, TRANSMISSÃO DA HERANÇA CULTURAL E PRODUÇÃO DA IDENTIDADE NACIONAL: A EMERGÊNCIA DA EDUCAÇÃO PARA O PATRIMÔNIO NA REFORMA DO ENSINO SECUNDÁRIO EM PORTUGAL (1894-1895)
Authors: Henriques António 
Published: May 2018

O texto analisa como a mais sistemática e informada reforma do ensino secundário no século XIX em Portugal, datada de 1894-1895, configura os valores preponderantes para reconhecer a herança cultural do país e dessa forma inscrever duradouramente no currículo da educação pública a questão do patrimônio como fator estruturante da consolidação do Estado-nação. A reforma que leva o nome do principal político, pedagogo e investigador que nela participa, Jaime Moniz, atualiza o sistema português de ensino de acordo com as experiências internacionais, marcando um momento fundador da educação comparada e o ponto de adesão a uma pedagogia de âmbito universal. Tal como nas experiências pedagógicas de outros países, o alcance da instrução secundária joga-se, então, na formação de uma classe média com um conhecimento geral que serve de âncora para os estudos superiores e constitui o ponto comum da mentalidade nacional, da formação do espírito público e da união moral da nação.
APRENDIZAGEM PROFISSIONAL NO ESTÁGIO EM CRECHE: REPRESENTATIVIDADE E SIGNIFICADO ATRIBUÍDO A DIMENSÕES DA PEDAGOGIA
Authors: Araújo Sara Barros 
Published: May 2018

A formação profissional de educadores(as) de infância para o trabalho em creche tem sido reconhecida como influente na qualificação destes serviços, embora seja frequentemente caracterizada como insuficiente e/ou desajustada às necessidades associadas ao perfil e respetivas funções profissionais. O presente estudo situase na formação inicial de educadores(as) de infância, pretendendo analisar a representatividade e significado atribuído a dimensões pedagógicas na aprendizagem profissional no âmbito do estágio em creche. Dados oriundos de 41 relatórios de estágio foram sujeitos a análise dedutiva, com base em dimensões da pedagogia identificadas na literatura. Os resultados evidenciaram seis dimensões com maior representatividade e significado nos relatos das estagiárias: experimentação de atividades [propostas pelo adulto], observação da criança e dos seus contextos proximais, organização de espaços e materiais, organização do tempo, interação adulto-criança e envolvimento das famílias. Adiantam-se algumas implicações ao nível dos processos de formação, com incidência na experiência formativa em contexto de estágio em creche.