bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal growth and incidence of atopic dermatitis in early childhood: Results of the Ulm SPATZ Health Study
Authors: Logan Chad A. , Weiss Johannes M. , Reister Frank , Rothenbacher Dietrich , Genuneit Jon 
Published: May 2018

AbstractFetal growth may be a precursory factor in observed association between birthweight and atopic dermatitis (AD), however, recent studies utilizing fetal ultrasound-based data have reported contradictory results. This study aims to clarify previous findings through comprehensive investigation of association between several trimester-specific ultrasound-based anthropometric measures with AD diagnosis by age 3 years. Measurements of 386 newborns in the Ulm SPATZ Health Study were converted into adjusted z-scores categorized as “low” (≤1 SD below mean), “normal,” or “high” (≥1 SD above mean). AD cases were defined using parent- or pediatrician-report of physician-diagnosis or clinical diagnosis. Adjusted risk ratios (RR) with 95% confidence intervals (95% CI) were calculated using modified Poisson regression. Compared to normal, both low and high 2nd trimester abdominal circumference [RR 1.51, (95% CI 1.01; 2.24) and 1.83 (1.21; 2.76)], high 2nd trimester head- abdominal circumference ratio [1.69 (1.16; 2.48)], and faltering 2nd to 3rd trimester [1.59 (1.04; 2.43)] head circumference were associated with greater AD risk. High 3rd trimester femur length [0.54 (0.31; 0.94)] was associated with lower risk. Using more inclusive exposure cut-points (0.8 SD), lower 1st trimester crown-rump length was also associated with greater AD risk. Our data suggest several different patterns of fetal growth may be differentially associated with AD.
TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration
Authors: Tosi Gian Marco , Neri Giovanni , Caldi Elena , Fusco Fiorella , Bacci Tommaso , Tarantello Antonio , Nuti Elisabetta , Marigliani Davide , Baiocchi Stefano , Traversi Claudio , Barbarino Marcella , Eandi Chiara M. , Parolini Barbara , Mundo Lucia , Santucci Annalisa , Orlandini Maurizio , Galvagni Federico 
Published: May 2018

AbstractControversy still exists regarding the role of the TGF-β in neovascular age-related macular degeneration (nAMD), a major cause of severe visual loss in the elderly in developed countries. Here, we measured the concentrations of active TGF-β1, TGF-β2, and TGF-β3 by ELISA in the aqueous humor of 20 patients affected by nAMD, who received 3 consecutive monthly intravitreal injections of anti-VEGF-A antibody. Samples were collected at baseline (before the first injection), month 1 (before the second injection), and month 2 (before the third injection). The same samples were used in a luciferase-based reporter assay to test the TGF-β pathway activation. Active TGF-β1 concentrations in the aqueous humor were below the minimum detectable dose. Active TGF-β2 concentrations were significantly lower at baseline and at month 1, compared to controls. No significant differences in active TGF-β3 concentration were found among the sample groups. Moreover, TGF-β pathway activation was significantly lower at baseline compared to controls. Our data corroborate an anti-angiogenic role for TGF-β2 in nAMD. This should be considered from the perspective of a therapy using TGF-β inhibitors.
Novel human microbe-disease associations inference based on network consistency projection
Authors: Zou Shuai , Zhang Jingpu , Zhang Zuping 
Published: May 2018

AbstractIncreasing evidence shows that microbes are closely related to various human diseases. Obtaining a comprehensive and detailed understanding of the relationships between microbes and diseases would not only be beneficial to disease prevention, diagnosis and prognosis, but also would lead to the discovery of new drugs. However, because of a lack of data, little effort has been made to predict novel microbe-disease associations. To date, few methods have been proposed to solve the problem. In this study, we developed a new computational model based on network consistency projection to infer novel human microbe-disease associations (NCPHMDA) by integrating Gaussian interaction profile kernel similarity of microbes and diseases, and symptom-based disease similarity. NCPHMDA is a non-parametric and global network based model that combines microbe space projection and disease space projection to achieve the final prediction. Experimental results demonstrated that the integrated space projection of microbes and diseases, and symptom-based disease similarity played roles in the model performance. Cross validation frameworks and case studies further illustrated the superior predictive performance over other methods.
Antimicrobial and anti-biofilm activity of hexadentated macrocyclic complex of copper (II) derived from thiosemicarbazide against Staphylococcus aureus
Authors: Brahma Umarani , Kothari Richa , Sharma Paresh , Bhandari Vasundhra 
Published: May 2018

AbstractMultidrug-resistant pathogens causing nosocomial and community acquired infections delineate a significant threat to public health. It had urged to identify new antimicrobials and thus, generated interest in studying macrocyclic metal complex, which has been studied in the past for their antimicrobial activity. Hence, in the present study, we have evaluated the antimicrobial activity of the hexadentated macrocyclic complex of copper (II) (Cu Complex) derived from thiosemicarbazide against Gram-positive and Gram-negative bacteria. We observed increased susceptibility against standard isolates of Staphylococcus aureus with a minimum inhibitory concentration (MIC) range of 6.25 to 12.5 μg/mL. Similar activity was also observed towards methicillin resistant and sensitive clinical isolates of S. aureus from human (n = 20) and animal (n = 20) infections. The compound has rapid bactericidal activity, and we did not observe any resistant mutant of S. aureus. The compound also exhibited antibiofilm activity and was able to disrupt pre-formed biofilms. Cu complex showed increased susceptibility towards intracellular S. aureus and was able to reduce more than 95% of the bacterial load at 10 μg/mL. Overall, our results suggest that Cu complex with its potent anti-microbial and anti-biofilm activity can be used to treat MRSA infections and evaluated further clinically.
Macrophage migration inhibitory factor-794 CATT microsatellite polymorphism and risk of tuberculosis: a meta-analysis
Authors: Ma Mingbiao , Tao Lvyan , Liu Aihua , Liang Zhang , Yang Jiaru , Peng Yun , Dai Xiting , Bai Ruolan , Ji Zhenhua , Jian Miaomiao , Bao Fukai 
Published: May 2018

Tuberculosis (TB) is a chronic infectious disease that has been threatening public health for many years. Several studies have shown the relationship between the macrophage migration inhibitory factor (MIF)-794 CATT (MIF-794 CATT) microsatellite polymorphism and susceptibility to TB. However, the results remain inconclusive. Therefore, we aim to find out the impact of MIF-794 CATT microsatellite polymorphism on risk of TB by a comprehensive meta-analysis. We conducted a systematic study search in PubMed, Embase, the Cochrane Library, and the China National Knowledge Infrastructure (CNKI) up to October 2017. Five studies involving 836 cases and 678 controls were included in the current meta-analysis. We calculated the pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to estimate the association between the MIF-794 CATT microsatellite polymorphism and risk of TB. The reliability of the results were evaluated with trial sequential analysis (TSA). The results suggested that the MIF-794 CATT microsatellite polymorphism was significantly associated with the susceptibility of TB in all comparisons for allele (7 + 8 compared with 5 + 6, OR = 1.56, 95% CI = 1.31–1.87, P&lt;0.00001) and genotype (7/X + 8/X compared with 5/X + 6/X, OR = 1.81, 95% CI = 1.39–2.36, P&lt;0.0001). Therefore, the meta-analysis indicated the MIF-794 allele CATT7 and CATT8 may be a risk factor to increase the susceptibility of TB, which was confirmed by TSA.
Extending the Application of Tense and Agreement Measures: A Reply to Rispoli and Hadley (2018)
Authors: Leonard Laurence B. , Haebig Eileen , Deevy Patricia , Brown Barbara 
Published: May 2018

Purpose
In this reply, we respond to comments on our article “Tracking the Growth of Tense and Agreement in Children With Specific Language Impairment: Differences Between Measures of Accuracy, Diversity, and Productivity.”

Conclusion
The finite verb morphology composite can be disproportionately affected by frequently occurring grammatical forms produced through direct activation. This assumption was one of the reasons we wished to compare this measure to the tense marker total and the tense/agreement productivity score. The latter two measures provide valuable developmental information that is not available from the finite morphology composite. Yet, the finite verb morphology composite shows good diagnostic accuracy and an interpretable pattern of growth and is relatively stable across different sample sizes.
Dye‐sensitised solar cell utilising gold doped reduced graphene oxide counter electrode: influence of annealing time
Authors: Rahman Mohd. Yusri Abd. , Sulaiman Amirul Shafiq , Umar Akrajas Ali 
Published: May 2018

Gold doped reduced graphene oxide (rGO) films prepared via hummer method have been utilised as counter electrode of dye‐sensitised solar cell. The samples were subjected to various annealing times at 120°C. The effect of annealing time on the dark current and photovoltaic performance has been investigated. The power conversion efficiency varies with annealing time. The highest efficiency of 0.155% was achieved by the device utilising gold doped rGO annealed for 45 min. This is due to the device employing this sample possesses the smallest leak current.
The optical/NIR afterglow of GRB 111209A: Complex yet not unprecedented
Authors: Kann D. A. , Schady P. , Olivares E. F. , Klose S. , Rossi A. , Perley D. A. , Zhang B. , Krühler T. , Greiner J. , Nicuesa Guelbenzu A. , Elliott J. , Knust F. , Cano Z. , Filgas R. , Pian E. , Mazzali P. , Fynbo J. P. U. , Leloudas G. , Afonso P. M. J. , Delvaux C. , Graham J. F. , Rau A. , Schmidl S. , Schulze S. , Tanga M. , Updike A. C. , Varela K. 
Published: May 2018

Context. Afterglows of gamma-ray bursts (GRBs) are simple in the most basic model, but can show many complex features. The ultra-long duration GRB 111209A, one of the longest GRBs ever detected, also has the best-monitored afterglow in this rare class of GRBs.
Aims. We want to address the question whether GRB 111209A was a special event beyond its extreme duration alone, and whether it is a classical GRB or another kind of high-energy transient. The afterglow may yield significant clues.
Methods. We present afterglow photometry obtained in seven bands with the GROND imager as well as in further seven bands with the Ultraviolet/Optical Telescope (UVOT) on-board the Neil Gehrels Swift Observatory. The light curve is analysed by multi-band modelling and joint fitting with power-laws and broken power-laws, and we use the contemporaneous GROND data to study the evolution of the spectral energy distribution. We compare the optical afterglow to a large ensemble we have analysed in earlier works, and especially to that of another ultra-long event, GRB 130925A. We furthermore undertake a photometric study of the host galaxy.
Results. We find a strong, chromatic rebrightening event at ≈0.8 days after the GRB, during which the spectral slope becomes redder. After this, the light curve decays achromatically, with evidence for a break at about 9 days after the trigger. The afterglow luminosity is found to not be exceptional. We find that a double-jet model is able to explain the chromatic rebrightening. The afterglow features have been detected in other events and are not unique.
Conclusions. The duration aside, the GRB prompt emission and afterglow parameters of GRB 111209A are in agreement with the known distributions for these parameters. While the central engine of this event may differ from that of classical GRBs, there are multiple lines of evidence pointing to GRB 111209A resulting from the core-collapse of a massive star with a stripped envelope.
Update Augenheilkunde – Amblyopie und Refraktionsfehler
Authors: Joachimsen Lutz , Gross Nikolai , Lagrèze Wolf 
Published: May 2018

ZusammenfassungDer folgende Beitrag stellt zwei aktuelle Themen der Kinderophthalmologie in den Fokus, die vermutlich auch immer wieder in der kinder- und jugendärztlichen Praxis relevant sein werden: die Amblyopie und ihre Früherkennung inklusive Videorefraktometrie und Refraktionsfehler im Schulkindalter mit Fokus auf Myopie, deren Häufigkeit weltweit zunimmt
Safe Transcatheter Aortic Valve Replacement in a Patient with a Highly Mobile Aortic Valve Mass
Authors: Agbor-Etang Brian , Mukherjee Ashis , Sethi Prabhdeep , Pai Ramdas 
Published: May 2018

AbstractSome cardiac valve masses may have embolic potential with worrisome consequences. We describe the dilemmas of and solutions for a highly mobile papillary fibroelastoma on the aortic valve in a nonsurgical patient undergoing transcatheter aortic valve replacement. It was performed safely. The potential strategies to minimize the risk of embolization are discussed.
Kardioanästhesie: Monitoring und aktuelle hämodynamische Konzepte
Authors: Heringlake Matthias , Schmidt Christian , Brandt Sebastian 
Published: May 2018

ZusammenfassungDie Krankheitsschwere herzchirurgischer Patienten und die Komplexität der Eingriffe haben in den letzten Jahren deutlich zugenommen. Dies stellt nicht nur erhöhte Anforderungen an die neurologische und hämodynamische Überwachung, sondern macht es auch erforderlich, die hämodynamische Therapie – unter Berücksichtigung aktueller pharmakologischer Entwicklungen – individuell dem höheren Risikoprofil der Patienten anzupassen.
Wirksamkeit psychologischer Interventionen zur Reduktion des Tabakkonsums
Authors: Atzendorf Josefine , de Matos Elena , Piontek Daniela 
Published: May 2018

ZusammenfassungDie Mehrheit der Raucher in Deutschland hat eine geringe Aufhörmotivation. Als Alternative zur Tabakabstinenz kann der Tabakkonsum reduziert werden. Die vorliegende Arbeit gibt einen systematischen Überblick über den aktuellen Forschungsstand zur Wirksamkeit psychologischer Interventionen zur Reduktion des Tabakkonsums. Es wird gezeigt, dass psychologische Interventionen trotz heterogener Befunde den Tabakkonsum stichprobenübergreifend sowohl kurz- als auch langfristig reduzieren können. Vielversprechende Ergebnisse lieferten u. a. Interventionen mit Kurzberatungen und motivierenden Gesprächen.
PANDA-view: an easy-to-use tool for statistical analysis and visualization of quantitative proteomics data
Authors: Chang Cheng , Xu Kaikun , Guo Chaoping , Wang Jinxia , Yan Qi , Zhang Jian , He Fuchu , Zhu Yunping 
Published: May 2018

AbstractSummaryCompared with the numerous software tools developed for identification and quantification of -omics data, there remains a lack of suitable tools for both downstream analysis and data visualization. To help researchers better understand the biological meanings in their -omics data, we present an easy-to-use tool, named PANDA-view, for both statistical analysis and visualization of quantitative proteomics data and other -omics data. PANDA-view contains various kinds of analysis methods such as normalization, missing value imputation, statistical tests, clustering and principal component analysis, as well as the most commonly-used data visualization methods including an interactive volcano plot. Additionally, it provides user-friendly interfaces for protein-peptide-spectrum representation of the quantitative proteomics data.Availability and implementationPANDA-view is freely available at https://sourceforge.net/projects/panda-view/.Supplementary informationSupplementary data are available at Bioinformatics online.
GSCALite: a web server for gene set cancer analysis
Authors: Liu Chun-Jie , Hu Fei-Fei , Xia Meng-Xuan , Han Leng , Zhang Qiong , Guo An-Yuan 
Published: May 2018

Abstract

Summary
The availability of cancer genomic data makes it possible to analyze genes related to cancer. Cancer is usually the result of a set of genes and the signal of a single gene could be covered by background noise. Here, we present a web server named Gene Set Cancer Analysis (GSCALite) to analyze a set of genes in cancers with the following functional modules. (i) Differential expression in tumor versus normal, and the survival analysis; (ii) Genomic variations and their survival analysis; (iii) Gene expression associated cancer pathway activity; (iv) miRNA regulatory network for genes; (v) Drug sensitivity for genes; (vi) Normal tissue expression and eQTL for genes. GSCALite is a user-friendly web server for dynamic analysis and visualization of gene set in cancer and drug sensitivity correlation, which will be of broad utilities to cancer researchers.

Availability and implementation
GSCALite is available on http://bioinfo.life.hust.edu.cn/web/GSCALite/.

Supplementary information
Supplementary data are available at Bioinformatics online.
DNA methylation and inflammation marker profiles associated with a history of depression
Authors: Crawford Bethany , Craig Zoe , Mansell Georgina , White Isobel , Smith Adam , Spaull Steve , Imm Jennifer , Hannon Eilis , Wood Andrew , Yaghootkar Hanieh , Ji Yingjie ,   Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Mullins Niamh , Lewis Cathryn M , Mill Jonathan , Murphy Therese M 
Published: May 2018

AbstractDepression is a common and disabling disorder, representing a major social and economic health issue. Moreover, depression is associated with the progression of diseases with an inflammatory etiology including many inflammatory-related disorders. At the molecular level, the mechanisms by which depression might promote the onset of these diseases and associated immune-dysfunction are not well understood. In this study we assessed genome-wide patterns of DNA methylation in whole blood-derived DNA obtained from individuals with a self-reported history of depression (n = 100) and individuals without a history of depression (n = 100) using the Illumina 450K microarray. Our analysis identified six significant (Šidák corrected P < 0.05) depression-associated differentially methylated regions (DMRs); the top-ranked DMR was located in exon 1 of the LTB4R2 gene (Šidák corrected P = 1.27 × 10−14). Polygenic risk scores (PRS) for depression were generated and known biological markers of inflammation, telomere length (TL) and IL-6, were measured in DNA and serum samples, respectively. Next, we employed a systems-level approach to identify networks of co-methylated loci associated with a history of depression, in addition to depression PRS, TL and IL-6 levels. Our analysis identified one depression-associated co-methylation module (P = 0.04). Interestingly, the depression-associated module was highly enriched for pathways related to immune function and was also associated with TL and IL-6 cytokine levels. In summary, our genome-wide DNA methylation analysis of individuals with and without a self-reported history of depression identified several candidate DMRs of potential relevance to the pathogenesis of depression and its associated immune-dysfunction phenotype.
Stereoelectroencephalography for Refractory Epileptic Patients Considered for Surgery: Systematic Review, Meta-Analysis, and Economic Evaluation
Authors: Garcia-Lorenzo Borja , del Pino-Sedeño Tasmania , Rocamora Rodrigo , López Juan Erviti , Serrano-Aguilar Pedro , Trujillo-Martín María M 
Published: May 2018

Abstract

BACKGROUND
Stereoelectroencephalography (SEEG) has been shown to be a valuable tool for the anatomoelectroclinical definition of the epileptogenic zone (EZ) in patients with medically refractory epilepsy considered for surgery (RES patients). In Spain, many of those patients are not offered this diagnostic procedure.

OBJECTIVE
To evaluate the effectiveness, safety, and cost-effectiveness of SEEG to define the EZ in RES patients compared to no SEEG intervention, ie, remaining with further antiepileptic drugs.

METHODS
We undertook a systematic review with meta-analyses on the effectiveness and safety of SEEG. A cost-effectiveness analysis was conducted using a Markov model, which simulates the costs and health outcomes of individuals for a lifetime horizon from the perspective of the Spanish National Health Service. The effectiveness measure was quality-adjusted life years (QALYs). We ran extensive sensitivity analyses, including a probabilistic sensitivity analysis.

RESULTS
The EZ was found in 92% of patients who underwent SEEG (95% confidence interval [CI]: 0.87-0.96); 72% were eligible for epilepsy surgery (95% CI: 0.66-0.78) and 33% were free of seizures after surgery (95% CI: 0.27-0.42). Of the patients who underwent surgery, 47% were free of seizures after surgery (95% CI: 0.37-0.58). Complications related to implantation and monitoring of SEEG and the subsequent intervention occurred in 1.3% of patients (95% CI: 0.01-0.02). In the base case analysis, SEEG led to higher QALYs and healthcare costs with an estimated incremental cost-effectiveness ratio of 10 368 EUR per QALY (95% CI: dominant-113 911), making the probability of cost-effectiveness between 75% and 88%. Further sensitivity analyses showed that the results of the study were robust.

CONCLUSION
SEEG is a cost-effective technology in RES patients when compared to no SEEG intervention.