bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anaesthesia in Dental Medicine with Local Infiltrative Anaesthetic Technique Versus Diploe Anaesthesia Delivery Systems: Efficacy and Behaviour, an Experimental Study
Authors: Marques-Ferreira Manuel , Carrilho Eunice , Paulo Siri , Carrilho Teresa , Figueiredo José Pedro , Macedo Ricardo 
Published: July 2018

Introduction: This study aimed to compare the analgesic efficacy and the influence of local infiltrative anesthesia techniques, with diploe anesthesia, on the cardiac rhythmMaterial and Methods: We selected 32 healthy volunteers who were given both anaesthetic techniques on tooth 1.4 (0.45 mL of lidocaine with adrenaline, 1:80 000). In the first phase, the volunteers underwent periapical infiltrative anaesthesia. In the second phase, diploe anaesthesia was performed with a QuickSleeper® device. The parameters analysed were pulp response to the electrical test and heart rate of the participants. These parameters were evaluated on five different occasions: before anaesthesia (t0), immediately after anaesthesia (t1), 15 minutes later (t15), 30 minutes later (t30) and 60 minutes later (t60). Statistical analysis of the data was performed using SPSS 2.0 software, with α = 0.05.Results: With the diploe anaesthesia, a level of analgesia was obtained faster. There was a slight increase in heart rate soon after administration of diploe anaesthesia, which stabilized after t15 of the procedure. This technique still proved to be painless.Conclusion: Diploe anaesthesia demonstrated better results in terms of analgesia than the infiltrative anaesthesia. It has been reported to be easy, safe and an effective procedure that allows anaesthesia in almost all clinical situations. This approach may offer particular advantages for endodontic therapy, providing greater comfort for the patient.
Injuries in Portuguese Amateur Youth Football Players: A Six Month Prospective Descriptive Study
Authors: Nogueira Miguel , Laiginhas Rita , Ramos José , Costa Ovídio 
Published: July 2018

Introduction: This study analyzed the incidence and characteristics of injuries sustained by amateur youth football players in Portugal during season 2015 - 2016.Material and Methods: This is an observational descriptive study. We analyzed Portuguese youth football players’ injuries over six months of a season. A total of 529 players were divided according to their age in two groups (Under-17 and Under-19). Data on injuries were collected.Results: Throughout all 62 062.0 hours of exposure recorded, 248 injuries were reported in 173 different players. The average incidence of injury was 3.87 (95% CI = 2.81; 4.94) per 1000 hours of football exposure. There was a significantly higher average incidence of injury during matches – 14.22 (95% CI = 10.35; 18.09) per 1000 hours of exposure – when compared to the average incidence of injury during training – 2.06 (95% CI = 1.22; 2.90) per 1000 hours of exposure. This significance was also observed when the comparison was made within each age group. A traumatic mechanism was involved in 76.6% of all the injuries, while overuse was reported in 12.9%. The most common type was the injury that affected muscles and tendons (52.8%). The body location most commonly affected by injuries was the thigh (24.6%).Discussion: Even though is essential a better characterization of Portuguese athletes of younger age groups such as those discussed in this study, the results of the studied population are in agreement with the existing literature. However, this study provides more information that may be important to better target the Portuguese athletes’ training for injury prevention.Conclusion: This study provides descriptive data on injuries developed in a subpopulation of Portuguese amateur youth football players that could represent a focus for future prevention.
PENGGUNAAN MEDIA BAHAN ALAM UNTUK MENINGKATKAN KREATIVITAS ANAK
Authors: Fauziah Nadia 
Published: July 2018

The purpose of this research is to improve the creativity of children aged 5-6 years through natural materials in PAUD Bestari, Gunungsindur, Bogor. The research conducted in November 2012 applied action research approach two cycles. Each cycle consists of planning, acting, observing and reflecting. The research subject were eleven kindergarten children having creativity problems. The final result of the overall data analysis indicates the hypothesis is accepted meaning that using natural materials can improve the creativity of children aged 5-6 years old.
MENINGKATKAN KETERAMPILAN PROSES SAINS MELALUI PENDEKATAN INKUIRI
Authors: Susanti Rini 
Published: July 2018

The purpose of this research is to improve the science process skills of the children aged 5-6 years through inquiry approach at TK Kasih Ibu, South Jakarta. The research conducted in November and December 2012 employed classroom action research within two cycles. Each cycle consisted of planning, acting, observing, and reflecting. The subjects of this research were 12 kindergarten children. The data were collected using test and non test. After the second cycle, the research concluded that the inquiry approach can improve the science basic skills of children aged 5-6 years old. The implication of this research is inquiry approach can be alternative way to improve science process skills of children aged 5-6 years old. The improvement of the science basic science can be demonstrated through observing, comparing, classifying, measuring and communication.
PENGARUH POLA ASUH ORANG TUA TERHADAP KEMAMPUAN SOSIAL ANAK USIA 6-7 TAHUN
Authors: Lestiawati I Made 
Published: July 2018

This research aims to know the pattern of parenting to social child ability of age 6-7 year at SDN Menteng 02 Pagi Jakarta Pusat. Research method used by Ex Post Facto. Technique of Intake sample is cluster random sampling with the amount sample is 46 child, then conducted spreading quesioner to determine the pattern group of the autoritary and democratic parent. Technique analyze the data used to test the hypothesis is uji-t after beforehand conducted by a prerequisite test that is test the normalitas. Result of examination of normalitas data use the test Liliefors of group A that is Lacount 0,113 < Ltabel 0,173 and group B by Lacount 0,065 < Ltabel 0,173 meaning data have normal distribution. Hypothesis examination use the uji-t of level signifikansi Î± = 0,05 obtained tacount =94,8 bigger than ttabel = 1,68, this means hypothesis of zero (Ho) refused, so that mean hypothesis alternative (ha) itâ€™s accepted that pattern of parenting have an effect on to social child ability. Matter of this means social ability of child is higher with the democratic parent than the autoritary parent. Result of research show there are influence which are positive significant between pattern of parenting to social child ability, where social ability of child is higher with the democratic parent than the autoritary parent. Implication from this research that pattern of the democratic parent can develop the social ability of high child as tool interaction with the area. Parent can give correct of take care so that the social ability of child is advance.
High Performance Capillary Electrophoresis Characteristic Fingerprint of Schisandra chinensis
Authors: Sun Yunpeng , Qian Min , Yuan Guangxin , Yang Hui , Cui Xinyuan , Li Yingnuo 
Published: July 2018

Background:
The quality control indexes detected by the existing methods are less and lack
specificity, and cannot truly reflect their intrinsic quality because of the similarity of Schisandra chinensis
and Schisandra sphenanthera in both their appearance and their main chemical composition. Therefore,
it is urgent to establish an effective method for the quality control of the both. High-performance
capillary electrophoresis (HPCE) method was used to establish the fingerprints of Schisandra medicinal
materials.

Methods:
The HPCE was performed, in which a 50µm × 50cm (the effective length was 41.5cm) uncoated
fused silica capillary column was applied, the buffer solution was 10 mM phosphate buffer (pH
8)-37.5 mM SDS-35% acetonitrile (v/v), the working voltage was 28 kV, the temperature was 25°C, the
samples were injected at 50mbar pressure for 3s, and the detection wavelength was 214nm. The chromatographic
fingerprints of samples were analyzed using “traditional Chinese medicine chromatographic
fingerprint similarity evaluation system 2004A version” software and cluster analysis.

Results:
10 common peaks were confirmed and 8 components were identified in the HPCE fingerprints
of 20 batches of Schisandra chinensis and Schisandra sphenanthera, and the results of clustering were
consistent with those of similarity evaluation.

Conclusion:
This method should be accurate and reliable, and can provide a scientific basis for the
quality evaluation of Schisandra medicinal materials.
Quantification of Genotoxic Impurities in Key Starting Material of Sertraline Hydrochloride by Simple and Sensitive Liquid Chromatography Technique
Authors: Anerao Ajit , Solase Vishal , Gadhave Thaksen , More Amol , Pradhan Nitin 
Published: July 2018

Background:Schiff base is an advanced key starting material of Sertraline hydrochloride. Schiff base is synthesized using two raw materials 1-Naphthol and 1,2-Dichlorobenzene which are potentially genotoxic impurities.Objective:Genotoxic impurities need to be controlled in key starting material to avoid carry forward in the active pharmaceutical ingredient. For trace level quantification of impurities a sensitive, accurate and cost effective method is developed by simultaneous estimation of both impurities.Methods:Reverse phase high performance liquid chromatography (HPLC) method was developed and validated for determination of both impurities in Schiff base. HPLC column Cosmosil MS-II C18, 100 mm X 4.6 mm, 3 μm particle size with ultra-violet detector (UV) was used.Results:The calibration curve of 1-Naphthol and 1,2-Dichlorobenzene showed good linearity over the concentration range of 0.25 µg/g to 7.5 µg/g and 1.5 µg/g to 7.5 µg/g and the regression coefficient was 0.999 and 0.998 respectively. Method had very low limit of detection (LOD) and limit of quantification (LOQ) of both analytes which proves that the method is sensitive and suitable for quantification of compounds at trace level.Conclusion:The proposed method is specific, linear, accurate, rugged and precise. Genotoxic impurities 1-Naphthol and 1,2-Dichlorobenzene are quantified and controlled in the key starting material of Sertraline hydrochloride. The validated method can be used in quality control unit in pharmaceutical industry.
Simultaneous Determination of Hydrochlorothiazide in Combination with Some Antihypertensive Drugs in The Presence of Its Main Impurities in Pure Form and Pharmaceutical Formulations
Authors: Salem Maissa Yacuob , Hassan Nagiba Yehia , Fayez Yasmin Mohamed , ElSabour Samah Abd , Ali Enas Shaaban 
Published: July 2018

Background:Hydrochlorothiazide (HCTZ) is potent diuretic that is used alone or in combination with other drugs such as labetalol (Lab) (mixtures Ι) or nebivolol (Neb) (mixtures ΙΙ) to control moderate to sever hypertension.Introduction:This paper demonstrates the establishment of different validated spectrophotometric and chemometric methods for simultaneous estimation of these mixtures in pure form and pharmaceutical formulations in the presence of HCTZ related impurities in quality control laboratories.Methods:(A) Derivative method (D3) of Lab and HCTZ and its related impurities at 245.3nm and 278.5nm respectively, (D1) of Neb and HCTZ at 294.2nm and 282.2nm, respectively. (B) First derivative of ratio spectra method (DD 1) of Lab at 244.3nm, HCTZ at 261.2nm and 275.4nm, while at 294nm for Neb and 269.4nm for HCTZ. (C) Ratio difference method which depends on measuring the distinction between the amplitudes of ratio spectra at 240nm and 288.3nm for Lab and at 270.1nm and 277.4nm for HCTZ for mixture Ι while at 290.4nm and 299.2nm for Neb and at 232.2nm and 254nm for HCTZ for mixture ΙΙ. (D) Mean centering of ratio spectra (MC) and (E) partial least squares regression (PLS) and principal component regression (PCR).Results:These methods were applied over concentration ranges of 10-100 µg/ml, 10-75 µg/ml and 2.5- 25 µg/ml of Lab, Neb and HCTZ, respectively. Methods were validated according to ICH guidelines and statistical comparison of results of reported and proposed methods revealed no difference.Conclusion:The methods were successfully used for the frequent analysis of selected mixtures in quality control laboratories.
Silver Nanoparticle-Based Arrays into Mesoporous Thin Films Structures for Photoelectronic Circuits
Authors: Delgado González Diana Catherine , Di Donato Andrés , Catalano Paolo Nicolas , Bellino Martín Gonzalo 
Published: July 2018

Background:
Silver nanosystems have attracted considerable attention for numerous applications
in optoelectronics. The localized surface plasmon of silver nanoparticles embedded into
mesoporous titania gives rise to an enhancement of local optical field in the vicinity of Ag nanoparticles
which act as efficient light-trapping components, resulting in a visible wavelength-dependent
photocurrent.

Objective:
In this paper, we synthetized patterned nanocomposites formed by titania mesoporous thin
films loaded with alkanethiol functionalized Ag nanoparticles and we demonstrated that these stable
and accessible nanostructures possess a photocurrent response.

Method:
Mesoporous thin films are created by combining sol-gel synthesis and template selfassembly.
Based on a photolithography technique, silver nanoparticles were selectively photodeposited
and then stabilized with octanethiols. Current vs. voltage curves with and without light
were compared, where selective light wavelength measurements were achieved by using visible
bandpass filters. The optofluidic behavior was evaluated by placing a drop of solutions on the
mesoporous film.

Results:
We demonstrate photocurrent in these mesoporous thin film structures decorated with
chemistabilized Ag nanoparticle-based conductive arrays, with significantly enhanced photocurrent
peak at the plasmon resonant wavelength around 540 nm. Our findings offer a possibility to perform
improved fluid detection with silver-mesoporous titania electronic devices.

Conclusion:
We showed that an optofluidic sensitive nanocomposite circuit consisting of alkanethiol-
functionalized metal nanoparticles embedded in a mesoporous oxide thin film matrix can be
produced.
Effects of Calcination on Sol-gel Synthesis of Hollow Spherical 8%B-TiO2 for Photocatalytic Degradation of RBR X-3B -Characterization and Activity
Authors: Yang Lili , Zhao Yao , Li Jing , Zhou Yanwen , Xiao Xuan , Zhang Wenjie 
Published: July 2018

Background:
TiO2-based materials can be utilized in both polluted air and wastewater
treatments. Ion doping is the most applied modification method, and many kinds of metal ions and
nonmetal ions are doped into a TiO2 crystalline skeleton. The hollow spherical photocatalyst can
both easily suspend in wastewater under aeration and settle down after treatment to release the water.

Methods:
The hollow spherical B-TiO2 photocatalyst was prepared by a sol-gel method. Tetrabutyl
titanate and tributyl borate were used as the titanium and boron sources. The materials were characterized
by X-ray diffraction (XRD), scanning electron microscope (SEM), infrared spectrum (FTIR),
and N2 adsorption-desorption techniques.

Results:
The 8%B-TiO2 material is composed of anatase TiO2 when the calcination temperature is
below 600°C. The graphical template is burnt out during calcination to leave a hole in the spherical
8%B-TiO2. The BET surface area of the materials declines from 53.2 m2/g at 400°C to 10.6 m2/g at
700°C. High-temperature thermal treatment results in the small surface area and large pore size. The
activity of the 8%B-TiO2 materials was studied on adsorption and photocatalytic degradation of RBR
X-3B dye. The 8%B-TiO2 sample prepared at 600°C has the maximum activity on RBR X-3B degradation.
After five cycles, decoloration efficiency on the 8%B-TiO2 decreases from 100% in the
first cycle to 80% in the fifth cycle.

Conclusion:
Photocatalytic activity of the hollow spherical material depends on calcination temperature
with the optimum activity on the sample obtained at 600°C. The hollow spherical 8%B-TiO2 has
satisfactory performance for recycling. Photocatalytic degradation of RBR X-3B can be proven by
the UV-Vis spectra during the degradation process.
Molecular Design and Synthesis of New 3,4-Dihydropyrimidin-2(1H)-Ones as Potential Anticancer Agents with VEGFR-2 Inhibiting Activity
Authors: Mostafa Amany S. , Bayoumi Waleed A. , El-Mesery Mohamed , Elgaml Abdelaziz 
Published: July 2018

Background:
Two series of 3,4-dihydropyrimidin-2(1H)-one derivatives were designed based on
the main structural features characterizing reported anticancer compounds with potent VEGFR-2 inhibiting
activity.

Methods:
All the target compounds were synthesized and investigated for their in vitro anticancer activity using
MTT assay and NCI protocol. The most active compounds were further investigated for the VEGFR-2 inhibiting
activity using enzyme inhibition assay.

Results:
Of these derivatives, compound 8b possessed significant activity against Caco-2 (IC50 of 24.9 µM) and
MCF7 (IC50 of 29.4 µM), compound 10 showed excellent potency against HCT-116 (IC50 of 32.6 µM),
HEPG2 (IC50 of 16.4 µM) and MCF7 (IC50 of 32.8 µM), while compound 11b exhibited moderate anticancer
activity towards MCF7 (IC50 of 41.7µM). Both 8b and 10 exhibited good potency regarding the inhibition of
vascular endothelial growth factor receptor 2 (VEGFR-2), with an IC50 of 14.00 and 21.62 nM, respectively.

Conclusion:
The activity was rationalized based on molecular docking study that supported their VEGFR-2
inhibitory activity; as indicated by their favorable binding with the active site.
Pengembangan modul pembelajaran aksara jawa “Dinta Swara” dalam huruf Braille untuk siswa tunanetra
Authors: Triyanto Triyanto , Rudiyati Sari 
Published: July 2018

Penelitian ini bertujuan untuk: (1) menghasilkan modul pembelajaran aksara Jawa“dinta swara” yang sesuai untuk siswa tunanetra, dan (2) mengukur efektifitas modul pembelajaran aksara Jawa dalam meningkatkan kemampuan siswa tunanetra mengenai baca tulis aksara Jawa dalam huruf Braille. Pengembangan modul pembelajaran ini dilakukan melalui studi pendahuluan, pembuatan desain produk, produk akhir, dan evaluasi. Hasil penelitian menunjukkan bahwa modul pembelajaran aksara Jawa dalam huruf Braille efektif dalam meningkatkan kemampuan siswa tunanetra mengenai pelajaran bahasa Jawa, khususnya dalam materi baca tulis aksara Jawa. Peningkatan kemampuan tersebut terlihat dari hasil pretest dan posttest yang dilakukan. Pada pretest uji coba kelompok kecil diperoleh hasil 40,00, pada posttest uji coba kelompok kecil diperoleh hasil 7,33. Sedangkan pada pretest uji coba lapangan lebih luas diperoleh hasil 44,00, dan pada posttest uji coba lapangan lebih luas diperoleh hasil 70,66.Kata kunci: modul pembelajaran, aksara jawa, huruf braille, siswa tunanetra DEVELOPING A MODULE FOR THE LEARNING OF THE JAVANESE ALPHABET “DINTA SWARA” IN BRAILLE FOR BLIND STUDENTAbstractThis study aims to: (1) produce a module of learning Java script "dinta swara" appropriate for blind students, and (2) measure the effectiveness of Javanese script module in improving the ability of students with visual impairment about reading Javanese script in Braille. The development of this learning module is done through preliminary study, product design, final product, and evaluation. The results showed that the Javanese script module in Braille is effective in improving the ability of blind students on Javanese lesson, especially in Javanese literacy reading material. Improvement of ability is seen from result of pretest and posttest done. In the small group trial pretest obtained 40.00 results, in small group trial posttest obtained results 7.33. While in pretest field trial more broadly obtained result 44,00, and at posttest field trial more broadly obtained result 70,66.Keywords: learning module, Javanese script, braille, blind student
O "Urbanismo" em disputa
Authors: De Mello Bruno Cesar Euphrasio , Rovati João Farias 
Published: July 2018

O artigo apresenta a experiência pioneira do curso de Urbanismo do Instituto de Belas Artes do Rio Grande do Sul (1947-1949), retratando um tempo em que essa formação profissional era objeto de disputa entre engenheiros e arquitetos. O artigo fundamenta-se em amplo corpus documental, envolvendo o processo administrativo de fundação do curso, os exercícios didáticos e os conteúdos ministrados em suas disciplinas.
Linked Data in a Nutshell: A Starter Kit of Selected Annotated Bibliography and Resources for Academic Librarians: Part One
Authors: Liu Weiling 
Published: July 2018

It has been a decade since Tim Berners-Lee coined Linked Data in 2006. More and more Linked Data datasets have been made available for information retrieval on the Web. It is essential for librarians, especially academic librarians, to keep up with the state of Linked Data. There is so much information about Linked Data that one may wonder where to begin when they want to join the Linked Data community. With this in mind, the author compiled this annotated bibliography as a starter kit. Due to the many resources available, this list focuses on literature in English only and of specific projects, case studies, research studies, and tools that may be helpful to academic librarians, in addition to the overview of Linked Data concept and the current state of Linked Data evolution and adoption.
A Directory to International LIS Education Accreditation Processes: Part III
Authors: Ren Xiaoai 
Published: July 2018

We will continue to look at LIS education accreditation processes across the world in Part III of this directory. This time, readers will find information on the accreditation processes for LIS education in New Zealand. Any new LIS education programs and degrees offered by universities in New Zealand, or any significant changes made to the existing structure of LIS education programs in New Zealand universities must get approval from the Committee on University Academic Programmes (CUAP). The Library and Information Association of New Zealand Aotearoa (LIANZA) assesses the LIS education providers in New Zealand on their coverage of the body of knowledge regularly.
Genetic Methods for Detecting Astrocytes, Neurons and Neurogenesis
Authors: Shusharina Natalia Nikolaevna , Silina Ekaterina Vladimirovna , Vasilyev Aleksandr Alexandrovich , Dominova Irina Nikolaevna , Stupin Victor Aleksandrovich , Sinelnicova Tatiana Georgievna , Sotnikov Egor Borisovich , Turkin Andrey Victorivich , Patrushev Maksim Vladimirovich 
Published: July 2018

Abstract
Two sets of reactants for modelling neurogenesis (SRMN) were developed based on the designed and tested genetic structures of lentiviral vectors. SRMN-1 contains the genetic construct LVV-GFAP-GCaMP3 and is intended for cellspecific transduction in astroglia cells. SRMN-2 contains the genetic construct LVV-PRSx8-TN-XXL and is intended for the phenotype-specific transduction in neurons. The present study examined SRMN-1 and SRMN-2 samples and assessed their efficiency in vitro and in vivo in Norvegicus rats. Specificity to particular cell types for all SRMN samples exceeded 97%. The number of induced signalling cascades was determined via activation of intracellular ingsignalling cascades in neurons and astrocytes (purinergic receptors and β-adrenoceptors). The results demonstrated dynamic recording of fluorescent signals and a two-fold increase in intensity after addition of the activator in all samples. The experimental SRMN samples revealed successful and stable transfection of catecholaminergic neurons and astrocytes, data on transfection efficiency, specificity of the developed genetic structures of SRMN, and calcium dynamics in transfected neurons and astrocytes.
These results confirm the crucial role of astrocytes in ensuring neurogenesis. The results in pure cell culture (in vitro) were identical to the in vivo results in animals.