bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baikal glacier system, new findings
Authors: Ananicheva M. D. , Pakin G. Yu. , Kononov Yu. M. 
Published: March 2019

Three glaciers and other small glacial formations, which are not mentioned in the USSR Catalog of glaciers as well as in any published article, were found in the area of the Verkhneangarsky (upper Angara) Range on satellite images. Earlier, researchers from the Institute of Geography of Siberian Branch of RAS described a group of glaciers on the Baikal Mountains and the Barguzin Range, which together with the above group of the Verkhneangarsky Range are related to the Baikal basin by the climate conditions. Ogdynda-Maskit Glacier has been described on the spot in 2017, while other glaciers and snow patches are to be investigated in situ in 2018. Together with the above Baikal and Barguzin glaciers, new data allow identification of the Baikal Glacial system. The article presents analysis of climate changes in the region. Trends in mean annual temperature range from 1 to 4 °C/50 years, while the same of summer temperatures change from 1 to 3 °C/50 years, but without any evident spatial distribution between them. Another situation takes place in the spatial distribution of precipitation: trends in total precipitation decrease towards the Baikal Lake, while precipitation of the cold period, on the contrary, slightly increases towards the Lake, but with rather small trend – 10–40 mm per 50 years. The last fact confirms the influence of the Baikal basin on the alimentation of glaciers and snow patches on the Verkhneangarsky Range. Currently, glaciers of the Verkhneangarsky Range undergo a slow regression.
Changes of the mass balance of the Garabashy Glacier, Mount Elbrus, at the turn of 20th and 21st centuries
Authors: Rototaeva O. V. , Nosenko G. A. , Kerimov A. M. , Kutuzov S. S. , Lavrentiev I. I. , Nikitin S. A. , Kerimov A. A. , Tarasova L. N. 
Published: March 2019

Long-term series of observations on the glacier of the southern slope of Elbrus manifest the change of two climatic periods in the highlands of the Caucasus. During the first one, relatively cold and snowy period of 1982–1997 with a small positive mass balance, the Garabashi Glacier accumulated a layer of 0.8 m.e. The second period (1998–2017) is characterized by rising summer air temperatures and increasing precipitation in the first decade, and catastrophic melting in 2010–2017. The mass balance of the glacier averaged −0.63 m w.e. yr−1, and in some years it reached −1.00 ÷ −1.50 m w.e. yr−1. In the last ten years, frequency of vast anticyclones covering the southern part of the European part of Russia and the North Caucasus increased. Summer temperatures in the Elbrus region rose to almost the level of the 1950s that was the hottest decade of the XX century. Duration of the summer season on the glaciers increased. Active melting resulted in elevation of the equilibrium line of the Garabashy Glacier by 200 m. In the main part of the glacier alimentation area, i.e. at heights of 3800–4000 m, the large parts of the firn area had disappeared, but open ice of the ablation zone had appeared. The former areas of the "warm" firn zone, where up to 35% of melt water retained within the 20‑meter firn thickness, were replaced by the firn-ice zone, and the ice discharge increased. The glacier alimentation is decreased, and its tongue retreats with increasing velocity. Rocks and entire lava ridges release from ice at different levels of the glacier. The inter-annual variations of the glacier mass balance are controlled by intensity of ablation. In the second period, the correlation coefficient of these values reached 0.97 compared to 0.82 in the first one. In total over 36 years of observations, reduction of the glacier mass during the second period resulted in loss of volume (0.05 km3 or 14%), area (0.51 km2 or 11.4%), and of ice layer (11.4 m).
The GPR-based estimation of the volumetric ice content of dispersed ground in the Central Yakut lowland
Authors: Neradovsky L. G. 
Published: March 2019

The previously unknown dependence between the volume ice content of frozen dispersed soils and their radiophysical properties (the speed of propagation and specific attenuation of the amplitude of electromagnetic waves) was studied in the layer of annual heat flows of Central Yakutia. The correlation between these characteristics determined in the laboratory and the method of discrete georadiolocation is established. The peculiarity of the connection is the sharp decline in the sensitivity of the propagation speed and the specific attenuation of electromagnetic waves in frozen dispersed soils with high volume ice content (more than 60%). In general, the specific attenuation of electromagnetic waves is more responsive to the change in the volume of ice content of frozen dispersed soils and, thus, it is more preferable to solve the problem of quantitative evaluation of this characteristic. The proposed method of reusable measurements of signals of georadiolocation with changing position and azimuth of antennas of georadars in the vicinity of the network points of geological and geophysical observations allows to estimate the average values of the propagation speed and specific attenuation of electromagnetic waves with an error of not more than 10%. Due to this, according to the equations of logistic functions it is possible to calculate the average values of volume ice content with an error of 7–11%. With this error, the picture of the probability distribution according to the georadiolocation values of the volume ice content in the averages is completely identical to the laboratory data. On this basis, the found regression equations are recommended to be used for the calculation of the speed of propagation and specific attenuation of electromagnetic waves of background or average values of the volume ice content of frozen dispersed soils of the annual heat transfer layer in any part of the ice complex of the Central Yakut lowland.
Status Keberlanjutan dan Strategi Pengelolaan Ekosistem Mangrove Kabupaten Mempawah, Propinsi Kalimantan Barat
Authors: Khairuddin Benny , Yulianda Fredinan , Kusmana Cecep , - Yonvitner 
Published: March 2019

Untuk mengelola ekosistem mangrove di Kabupaten Mempawah diperlukan suatu strategi pengelolaan ekosistem mangrove secara terpadu dan berkelanjutan dilakukan dengan melakukan evaluasi status keberlanjutan melalui 21 indikator yang dikelompokkan kedalam empat dimensi yaitu ekologi, ekonomi, sosial, hukum dan kelembagaan. Indikator-indikator tersebut diperoleh dari penelitian terdahulu, studi pustaka, CIFOR dan LEI menyangkut Sustainable forest management (SFM), serta berdasarkan pengamatan di lapangan. Hasil modifikasi indikator tersebut dinamai Rap-MEcosytem pada skala (0-100) memperlihatkan status keberlanjutan pengelolaan ekosistem mangrove multidimensi dinyatakan cukup berkelanjutan dengan indeks 52,83 begitu halnya dimensi ekonomi 59,66, sosial 59,27 dan hukum/kelembagaan 52,33 sedangkan dimensi ekologi memiliki status kurang berkelanjutan 44,75 sehingga perlu mendapat prioritas perbaikan. Hasil evaluasi di lanjutkan dengan Analytic Hierarchy Process (AHP) sehingga didapatkan strategi pengelolaan dengan prioritas : (a) melengkapi legalitas pengelolaan wilayah pesisir dengan menyusun Rencana zonasi Pengelolaan Wilayah Pesisir dan Pulau-Pulau Kecil (RZWP-3K) dan turunannya, (b) meningkatan personil, kapasitas, kualitas, sarana dan prasarana petugas penyuluh perikanan dan kelautan yang hanya berjumlah 5 orang serta penyuluh kehutanan yang berjumlah 6 orang, (c) melakukan reboisasi dan rehabilitasi ekosistem mangrove terutama di Kecamatan Sungai Pinyuh yang paling banyak mengalami degradasi.
The EMA Review of Mylotarg (Gemtuzumab Ozogamicin) for the Treatment of Acute Myeloid Leukemia
Authors: Ali Sahra , Dunmore Helen-Marie , Karres Dominik , Hay Justin L. , Salmonsson Tomas , Gisselbrecht Christian , Sarac Sinan B. , Bjerrum Ole W. , Hovgaard Doris , Barbachano Yolanda , Nagercoil Nithyanandan , Pignatti Francesco 
Published: March 2019

Abstract

On February 22, 2018, the Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product gemtuzumab ozogamicin (Mylotarg; Pfizer, New York City, NY), intended for the treatment of acute myeloid leukemia. Mylotarg was designated as an orphan medicinal product on October 18, 2000. The applicant for this medicinal product was Pfizer Limited (marketing authorization now held by Pfizer Europe MA EEIG).
The demonstrated benefit with Mylotarg is improvement in event-free survival. This has been shown in the pivotal ALFA-0701 (MF-3) study. In addition, an individual patient data meta-analysis from five randomized controlled trials (3,325 patients) showed that the addition of Mylotarg significantly reduced the risk of relapse (odds ratio [OR] 0.81; 95% CI: 0.73–0.90; p = .0001), and improved overall survival at 5 years (OR 0.90; 95% CI: 0.82–0.98; p = .01) [Lancet Oncol 2014;15:986–996]. The most common (&gt;30%) side effects of Mylotarg when used together with daunorubicin and cytarabine are hemorrhage and infection.
The full indication is as follows: “Mylotarg is indicated for combination therapy with daunorubicin (DNR) and cytarabine (AraC) for the treatment of patients age 15 years and above with previously untreated, de novo CD33-positive acute myeloid leukemia (AML), except acute promyelocytic leukemia (APL).”
The objective of this article is to summarize the scientific review done by the CHMP of the application leading to regulatory approval in the European Union. The full scientific assessment report and product information, including the Summary of Product Characteristics, are available on the European Medicines Agency website (www.ema.europa.eu).
Improving CKD-Specific Patient-Reported Measures of Health-Related Quality of Life
Authors: Ware John E. , Richardson Michelle M. , Meyer Klemens B. , Gandek Barbara 
Published: March 2019

Significance Statement
Monitoring patient-reported outcomes to capture CKD’s effects on health-related quality of life (QOL) is important for population health and individual care. Current measures such as the Kidney Disease Quality of Life-36 (KDQOL-36) do not incorporate some proven measurement advances, and measures incorporating such advances are rarely compared with current methods. The authors evaluated the validity of a new approach to CKD-specific QOL measurement that comprehensively represents CKD-specific QOL, yields a single summary QOL impact score, and generally requires only 1 minute. Across CKD stages 3–5, dialysis, and transplant patients, results favored the new approach over the KDQOL-36 in comparisons of validity, including responsiveness (sensitivity to clinical change), across multiple clinical tests. Computerized adaptive test versions of the new approach were more efficient than static versions.

Background
Patient-reported outcome measures that are more practical and clinically useful are needed for patients with CKD. We compared a new CKD-specific quality-of-life impact scale (CKD-QOL) with currently used measures.

Methods
Patients (n=485) in different treatment groups (nondialysis stages 3–5, on dialysis, or post-transplant) completed the kidney-specific CKD-QOL and Kidney Disease Quality of Life-36 (KDQOL-36) forms and the generic SF-12 Health Survey at baseline and 3 months. New items summarizing quality of life (QOL) impact attributed to CKD across six QOL domains yielded single impact scores from a six-item static (fixed-length) form and from computerized adaptive tests (CATs) with three to six items. Validity tests compared the CKD-QOL, KDQOL-36 (Burden, Effects, and Symptoms/Problems subscales), and generic SF-12 measures across groups in four tests of clinical status and clinician assessment of change (CKD-specific tests), and number of comorbidities. ANOVA was used to test for group mean differences, variances in each measure explained by groups, and relative validity (RV) in comparison with the referent KDQOL-36 Burden subscale.

Results
KDQOL-36 and CKD-QOL measures generally discriminated better than generic SF-12v2 measures. The pattern of variances across CKD-specific tests comparing validity favored CKD-QOL two-fold over KDQOL-36. Two RV test results confirmed CKD-QOL improvements over the referent KDQOL scale. Results for static and CAT CKD-QOL forms were similar. SF-12 Physical and KDQOL-36 Symptoms scores worsened with increasing comorbid condition counts.

Conclusions
Overall, compared with the KDQOL-36, the new approach to summarizing CKD-specific QOL impact performed better across multiple tests of validity. CAT surveys were more efficient than static surveys.
Kidney Disease Quality of Life 36-Item Short Form Survey (KDQOL-36) Normative Values for the United States Dialysis Population and New Single Summary Score
Authors: Peipert John D. , Nair Devika , Klicko Kristi , Schatell Dorian R. , Hays Ron D. 
Published: March 2019

Significance Statement
Reliable, valid, and interpretable patient-reported outcome measures for kidney patients are needed for patient monitoring and use as outcomes in clinical trials. The Kidney Disease Quality of Life 36-item short form survey (KDQOL-36) is often used with patients on dialysis, but improvements are needed to facilitate interpretability of its scores. The authors calculate normative values for the KDQOL-36 scales referenced to the United States dialysis population, which allow comparison of group means and individual scores with national averages, such as by dialysis centers when fulfilling their required annual assessment of patients’ quality of life. The authors also created the KDQOL-36 Summary Score (KSS), a composite of items from the KDQOL-36’s kidney-targeted scales, which may be useful when kidney-targeted health-related quality of life needs to be summarized in a single score.

Background
The Kidney Disease Quality of Life 36-item short form survey (KDQOL-36) is a widely used, patient-reported outcome measure for patients on dialysis. Efforts to aid interpretation are needed.

Methods
We used a sample of 58,851 dialysis patients participating in the Medical Education Institute (MEI) KDQOL Complete program, and 443,947 patients from the US Renal Data System (USRDS) to develop the KDQOL-36 Summary Score (KSS) for the kidney-targeted KDQOL-36 scales (Burdens of Kidney Disease [BKD], Symptoms and Problems of Kidney Disease [SPKD], and Effects of Kidney Disease [EKD]). We also used the MEI and USRDS data to calculate normative values for the Short Form-12 Health Survey’s Physical Component Summary (PCS) and Mental Component Summary (MCS), and the KDQOL-36’s BKD, SPKD, and EKD scales for the United States dialysis population. We used confirmatory factor analysis (CFA) models for KDQOL-36 kidney-targeted items, evaluated model fit with the comparative fit index (CFI; >0.95 indicates good fit) and root-mean-squared error of approximation (RMSEA; <0.06 indicates good fit), and estimated norms by matching the joint distribution of patient characteristics in the MEI sample to those of the USRDS sample.

Results
A bifactor CFA model fit the data well (RMSEA=0.046, CFI=0.990), supporting the KSS (α=0.91). Mean dialysis normative scores were PCS=37.8 and MCS=50.9 (scored on a T-score metric); and KSS=73.0, BKD=52.8, SPKD=79.0, and EKD=74.1 (0–100 possible scores).

Conclusions
The KSS is a reliable summary of the KDQOL-36. The United States KDQOL-36 normative facilitate interpretation and incorporation of patient-related outcome measures into kidney disease care.
Sitolojisi HGSIL gelen olgularda kolposkopik biopsi ile eksizyonel işlem sonuçlarının korelasyonu: 10 yıllık tersiyer merkez deneyimi
Authors: ERDEM Baki , AŞICIOĞLU Osman , TURAN Gökçe , YÜKSEL İlkbal Temel , GÜNKAYA Osman Samet , ÖZAYDIN İpek Yıldız , YILDIRIM İşıl Şafak , YILDIRIM Doğukan , AKBAYIR Özgür 
Published: March 2019

Amaç: Sitoloji sonucu yüksek
dereceli servikal intraepitelyal lezyon (HGSIL) olan olgularda, kolposkopik
biopsi ve ekzisyonel işlemler ile elde edilen patoloji sonuçları arasındaki
korelasyonu incelemek.

Gereç ve Yöntem: Toplamda 282
hastanın verilerine ulaşıldı. Tüm hastalara kolposkopik muayene yapıldı. Kolposkopik
biopsi sonucu invaziv kanser tanısı konulan 23 hasta klinik olarak evrelendi ve
uygun tedavi planlandı (radikal histerektomi veya kemoradyoterapi). Diğer
hastaların tümüne (n=259) eksizyonel işlemler (LEEP veya konizasyon) uygulandı.
Her iki işlemden elde edilen patoloji
sonuçlarından en yüksek dereceli olan final patoloji olarak kaydedildi.

Bulgular: Kolposkopik biopsi ile
eksizyonel işlemler arasında %73,7 oranında (n=191/259) uyum izlendi. 64
hastada ≤CIN1 (%22,7) bulunduğu ve bu grupta aşırı tedavi yapıldığı tespit
edildi. Hastaların %63,5’i (n=179) CIN2+, %13,8’i (n=39) ise invaziv kanser
idi. Kolposkopik biopsi invaziv kanserli hastaların %41’inde (n=16/39) eksik
patolojik tanıya neden oldu. Kolposkopik biopsi ile eksizyonel işlemler sonucu
elde edilen patoloji sonuçlarındaki uyumu saptamak için kappa analizi yapıldı.
κ: 0,542 olarak hesaplandı ve bu değer ılımlı derecede korelasyon anlamına
gelmekteydi.

Sonuç: HGSIL sitoloji sonucu ile
başvuran hastalarda kolposkopik biopsi ile eksizyonel işlemler arasında yaklaşık
4’te 3 oranında uyum bulunduğu tespit edilmiştir. CIN2+ ve invaziv kanser insidansının
bu hastalarda yüksek bulunması nedeniyle,bu hastalarda biopsi sonucu ≤CIN1
gelse bile eksizyonel işlem seçeneği sunulmasının daha doğru ve güvenli
olacağını düşünmekteyiz.
Numerical and Experimental Investigation of Bending Behavior of Pre-Stressed Aluminum Tube
Authors: EKŞİ Seçil , GENEL Kenan 
Published: March 2019

The effect of the pre-stress and internal Pa6 (cast-polyamide) material
on the bending behavior of the aluminum tube is investigated experimentally. Finite
element studies have been carried out to better understand the effect of
pre-stress on the cross-section of tube and to shed light on the experimental
studies. From the simulation studies, it was concluded that the effect of the
pre-stress on the load carrying capacity of the tube is limited. After finite
element studies, experimental studies were performed. In experimental studies,
the lower cross-section of the tube was subjected to 175 MPa stress
corresponding to 93% of the yield strength of the material. The tensile stress
in the tube during the loading is reduced by applying pressure to the lower
cross section of the tube beam. In addition, a change in the load carrying
capacity of the tube was investigated using a Pa6 ring to delay local buckling.
As a result of the experiments, it was found that the pre-stress significantly
improved the bending behavior of the tube in the elastic region, while reducing
buckling displacement. Application of both
pre-stress and internally reinforcement enhanced bending performance of the
tube in both elastic and plastic regions. Load carrying capacity of pre-stressed
and internally reinforced tube was increased 1.67 times
according to the base tube.
Selfadjointness and Positiveness of the Differential Operators Generated by New Type Sturm-Liouville Problems
Authors: OLĞAR Hayati 
Published: March 2019

It is purpose of this paper to investigate
Sturm-Liouville equation on many-interval with the eigenvalue parameter appearing linearly in the
boundary conditions and with two supplementary transmission conditions. The
classical Sturmian theory did not cover such type of many-interval boundary
value transmission problems. For the classical Sturm-Liouville problems it is
guaranteed that the problem is self-adjoint with compact resolvent, the
spectrum is disctrete and consist of eigenvalues and the corresponding
eigenfunctions form an orthogonal basis in the well-known Hilbert space . But the boundary-value-transmission problems are not
self-adjoint and the system of eigenfunctions did not form a basis in the
classical Hilbert space in general. Taking in
view this fact we suggest a new approach for self-adjoint realization of such
type transmission problems. Moreover, we define some new Hilbert spaces to
establish positiveness of corresponding operator-pencil. At first we define a
concept of generalized eigenfunctions for this kind of spectral problems. In
particular it is shown that if the potential is continuous then the
generalized eigenfunctions satisfies the considered problem is the classical
sense. Then we introduce to the consideration some compact operators such a way
that the considered boundary-value-transmission problem can be reduced to the
appropriate operator-pencil equation. Finally, we prove that this
operator-pencil is self-adjoint and positive definite for sufficiently large
negative values of the eigenparameter. It is important to note that the
obtained results extends classical results associated with regular
Sturm-Liouville problems.
Biosynthesis and Characterizatıon of Silver Nanopartıiles from the Lemon Leaves Extract
Authors: SERDAR Gönül , ALBAY Cansu , SÖKMEN Münevver 
Published: March 2019

The synthesis and characterization of Ag nanoparticles from Citrus limonum
(lemon leaves) collected the Eastern Black Sea region was investigated in
this study. A household microwave system device was used for microwave
extraction of lemon leaves samples. The extract was prepared by taking 10g of
dried lemon leaves. 10 g of sample was
shaken in 100 mL of water for 90 min and extracted in a household microwave
device at 4 minutes, 600 W. Ag
nanoparticles were synthesized that the obtained aqueous solution was taken in
different volumes by mixing 1 mM and 5mM AgNO3 solution. The colloid
solution was subjected to microwave in an oven 1, 3, 5, 10, 15, 20 and 30
minutes at 90, 180, 360 W. Then production of AgNPs, the mixture was watched by
UV-Vis spectroscopy (Shimadzu UVP-1240 spectrophotometer) measurements at
different wavelengths (300 – 800 nm) for SPR of silver nanoparticles. The transition from yellow to a dark brown,
shows the synthesis of silver nanoparticles.
Justicia por mano propia y su relación con el cumplimiento de los componentes paz, justicia e instituciones sólidas como objetivos de desarrollo sostenible
Authors: Berrocal Duran Juan C , MEJIA TURIZO JORGE , Martinez angulo Ivonne 
Published: March 2019

El presente artículo tiene como objetivo principal determinar los factores generadores de justicia por mano propia y su relación con el cumplimiento de objetivo de desarrollo sostenible ODS, especialmente en el componente relativo a “paz, justicia e instituciones sólidas”, a fin de establecer si el fenómeno de justicia por medios personales y extralegales puede constituir un indicador del cumplimiento de los ODS. Para la cual se analizaran una serie de variables cuantitativas y cualitativas de sujetos residentes en los sectores con mayores índices de violencia en Barranquilla. El tipo de investigación es de orden explicativo y se aplicó un método de naturaleza inductiva