bluuebunny/crossref_metadata_2025_split huggingface dataset:
The potential therapeutic role of Lisinopril in augmenting the striatal neuroplasticity via the striatal ACE2/Ang1-7/MAS receptor axis in 3-nitropropionic acid-induced Huntington’s disease in rats: shifting paradigms in Huntington’s disease treatment
Authors: Wanas Hanaa , Rabie Mostafa Adel , Aboulhoda Basma Emad , Ramadan Nagwa Mahmoud , Abdelwahab Sahar , Abdallah Sara Sayed Kadry , Ali Eid Nassar , Khayruddeen Leyan Nasruddeen , Elhassan Yasir Hassan , Alghabban Hadel Mahroos , Abdelsalam Shaimaa Mohamed , Khalifa Amira Karam 
Published: November 2024

Abstract
Background
The exact pathogenesis of Huntington’s disease (HD) remains unclear. However, mitochondrial dysfunction and oxidative stress are supposed to play a significant role. The objective of this study was to examine the possible neuroprotective effect of Lisinopril (Lisino) in a 3-nitropropionic acid-produced HD in rats.

Methods
Sixty-four rats were divided into four groups (16/group): Group (1): Normal control group, Group (2): Lisinopril control group, Group (3): 3-NP non-treated group, and Group (4): (3-NP + Lisinopril) group. Behavior assessments (open field test, rotarod test, grip strength test) were performed along with different histological and biochemical parameters.

Results
Lisinopril upregulated the expression of the ACE2/Ang1-7/MAS receptor (MasR) axis of RAS, which triggered the PI3K/Akt pathway and prompted the CREB/BDNF neurogenesis signal. Furthermore, Lisinopril remarkably downregulated the inflammatory cytokines (NF-κB, TNF-α, IFN-γ and IL-6), decreased apoptotic markers (p53, BAX/Bcl2 ratio, Cyt-c and caspase-3) and upgraded the mitochondrial TFAM content and SDH activity along with restoration of the redox mechanism by recovering SOD, catalase, GSH and Nrf2.

Conclusion
Notably, the outcomes of this study disclosed that Lisinopril could be a future neuroprotective therapeutic candidate against HD.
A fast prediction method of fatigue life for crane structure based on Stacking ensemble learning model
Authors: Zhao Jincheng , Dong Qing , Xu Gening , Li Hongjuan , Lu Haiting , Zhuang Weishan 
Published: November 2024

AbstractTo quickly obtain the fatigue life of cranes in service, the metal structure that determines the crane life is anchored. Meanwhile, the fast prediction method of fatigue life of crane metal structures based on the Stacking ensemble learning model is proposed. Firstly, in line with the structural stress method, the global rough model of the metal structure is established by the co-simulation technology to obtain the fatigue damage regions of the structure. The local fine model is constructed by local cutting and boundary condition transplantation to determine the critical weld at the failure regions. Secondly, through weld definition, equivalent structural stress acquisition, and fatigue life calculation, the sample data set with lifting load and trolley running position as input and fatigue life cycle times as output is constructed. Then, the Stacking integrated learning model combining gradient boosting, ridge regression, Extra Trees, and linear is built. On this basis, combined with the Miner theory, the rapid prediction of crane fatigue life is realized. Finally, the proposed method is applied to the QD40t × 22.5 m × 9 m general bridge crane. The results show that the life sample set constructed by the structural stress method is more accurate and reasonable than the nominal, hot spot, and fracture mechanics methods. The life prediction results of the Stacking integration model were improved by 6.3 to 49.2% compared to the single model. The method has theoretical and practical significance in reducing accidents and ensuring the safe operation of cranes.
Efficacy and tolerance of short cycles of palliative radiotherapy in advanced anal sac adenocarcinomas in dogs
Authors: Militi Mario , Botta Vittorio , Heidrich Ylva , Berlato Davide 
Published: November 2024

AbstractSuccessful management of advanced anal sac gland adenocarcinomas (AGASACA) often requires a multimodal approach. In recent years the role of palliative radiotherapy (pRT) has become increasingly more important, mainly in dogs with severe local clinical signs. This study describes efficacy and tolerance of short cycles of pRT. Retrospective single-institution study including dogs with AGASACA treated with at least one short cycle of pRT (IMRT, 4Gy BID for two consecutive days). All dogs were staged with CT and followed to death. Outcome measures were PFS and OST from the first pRT. Potential prognostic factors were evaluated. Twelve dogs were included (one stage II, four stage III, seven stage IV). Three dogs had one cycle, seven had two cycles, and two had three cycles of pRT. All dogs experienced a clinical benefit after pRT. One dog also had surgery, four systemic treatment, and five both. Eleven dogs died during the follow-up (four for local progression, six for systemic progression, one unknown). The median PFS was 198 days (95% CI 98—298) and the OST was 250 days (95% CI 124—376). Mild, acute, short-term GI toxicity occurred in seven dogs (five G1; two G2). None of the dogs experienced clinically relevant late toxicity. Short cycles of radiotherapy can be effectively used as a palliative treatment for advanced AGASACA with minimal toxicity. The small number of patients did not allow to assess the benefits of combining RT with other treatment modalities or the identification of meaningful prognostic factors.
Ectopic Cervical Thymic Tissue Mimicking Parathyroid Hyperplasia: A Rare Occurrence Linked to Graves Disease
Authors: Chatchomchuan Waralee , Thewjitcharoen Yotsapon , Nakasatien Soontaree , Suvikapakornkul Ronnarat , Keerawat Somboon , Himathongkam Thep 
Published: November 2024

Abstract
Thymic hyperplasia has occasionally been reported in patients with Graves disease (GD). However, ectopic cervical thymic hyperplasia in the setting of hyperthyroid GD is exceptionally rare. We describe a case of a 54-year-old Thai woman who presented with hyperthyroidism, diplopia, and pretibial myxedema. She underwent a total thyroidectomy because of diplopia caused by Graves ophthalmopathy. During the surgery, 3 macroscopically abnormal enlargements of parathyroid gland-like tissue were identified and removed. Histopathology revealed hyperplastic thymic tissue mixed with 1 normal-sized parathyroid gland at the location of the left upper parathyroid gland, and thymic tissue was found in the sample labeled as the right upper parathyroid gland. Notably, the sample labeled as the right lower parathyroid gland was actually determined to be a lymph node. Preoperative blood samples showed normal serum calcium and parathyroid hormone levels. Postoperatively, computed tomography of the chest showed thymic hyperplasia in the anterior mediastinum, which slightly regressed at the 9-month follow-up. The patient had transient hypoparathyroidism requiring oral calcium and active vitamin D supplements for 6 months postoperatively. Ectopic cervical thymic hyperplasia can be found in GD and might be indistinguishable from parathyroid hyperplasia. Biochemical evaluations are required to exclude concomitant hyperparathyroidism, and a conservative approach should be considered.
Hypoglycemia Associated With Hypermobile Ehlers-Danlos Syndrome
Authors: Saeed Hamayle , Sheehan Amanda , Patti Mary-Elizabeth 
Published: November 2024

Abstract
Hypoglycemia in the absence of diabetes is often multifactorial and challenging to diagnose definitively. We present a case report and an expanded series of adult females with reactive hypoglycemia who were diagnosed with Ehlers-Danlos syndrome (EDS). These patients exhibited predominantly postprandial hypoglycemia, with some fasting and activity-induced episodes. Clinical findings included autonomic dysfunction, gastrointestinal symptoms, and joint hypermobility. Interventions focused on medical nutrition therapy, continuous glucose monitoring, and, in some cases, medication. Many patients continued to experience hypoglycemic episodes despite treatment. Key learning points include the potential association between hypermobile EDS and hypoglycemia, the importance of confirming the Whipple triad, and the need for multidisciplinary management. This case series highlights the need for further research into the prevalence and pathophysiology of hypoglycemia in EDS.
Wpływ zbiorników retencyjnych na zmiany właściwości fizyczno-chemicznych wód i wielkości ładunku biogenów w Potoku Oruńskim
Authors: Cieśliński Roman , Jagielski Bartosz 
Published: November 2024

Celem głównym pracy była ocena wpływu trzech zbiorników retencyjnych w zlewni miejskiej Potoku Oruńskiego na zmiany cech fizyczno-chemicznych wód rzecznych. Oceniono także rolę zbiorników do akumulowania i odprowadzania ładunku azotu ogólnego i fosforu ogólnego. Prowadzono badania terenowe: pomiar natężenia przepływu, pobór próbek wody do analiz chemicznych, pomiary in situ przewodności elektrolitycznej właściwej i odczynu wody oraz laboratoryjne: oznaczono stężenia jonów – Ca2+, Mg2+, Na+, K+, HCO3−, Cl−, SO42−, NO3−, PO43− oraz azotu ogólnego i fosforu ogólnego. Obliczono ładunki chwilowe azotu ogólnego i fosforu ogólnego, a także wykonano obliczenia statystyczne m.in. korelację rangową Spearmana oraz test Tukeya i przeprowadzono analizę wariancji ANOVA. Miały one, między innymi, na celu obliczenie korelacji pomiędzy stężeniem azotu ogólnego i fosforu ogólnego, a pozostałymi badanymi wskaźnikami fizyczno-chemicznymi i jonami, w zależności od lokalizacji punktu pomiarowego i czasu poboru próbki. Na podstawie uzyskanych wyników stwierdzono duże zróżnicowanie stężeń analizowanych wskaźników fizyczno-chemicznych w poszczególnych punktach pomiarowych. Analiza zmienności ładunków fosforu ogólnego wykazała, że zbiornik Świętokrzyska I akumulował go praktycznie w całym okresie pomiarowym. Z kolei analiza ładunków azotu ogólnego udokumentowała, że wszystkie zbiorniki retencyjne wykazywały tendencję akumulacyjną tylko w trzech miesiącach – w grudniu, lipcu i październiku. Również w trzech miesiącach wszystkie zbiorniki wykazały zwiększenie odpływu ładunku azotu ogólnego (uwalnianie dodatkowych ilości azotu ogólnego w stosunku do tego, co doprowadza Potok Oruński) – w lutym, marcu i wrześniu. W pozostałych miesiącach rola każdego ze zbiorników była zróżnicowana, dlatego nie zostały ustalone schematy alokacji ładunku azotu ogólnego.
Distribution of bacterial pathogens and antimicrobial resistance in cows with clinical mastitis in a dairy farm, Türkiye
Authors: Guner B , Ozturk B , Erkan AA , Erturk M , Ucan N , Keskin A 
Published: November 2024

This study aimed to identify the pathogens causing clinical mastitis (CM) and their resistance levels to six common antimicrobials in a dairy farm in Turkey. A total of 973 CM milk samples were cultured and a Kirby-Bauer disc diffusion method was performed for antimicrobial susceptibility. While 64.0% (623/973) of CM samples were culture-positive, 36.0% (350/973) of CM samples yielded no growth. Escherichia coli was the most frequently isolated pathogen (36.3%), followed by coagulase-negative staphylococci (8.3%), Streptococcus dysgalactiae (7.3%), Staphylococcus aureus (3.1%), Streptococcus uberis (1.5%), Enterococcus spp. (1.4%), Mycoplasma spp. (1.4%), Streptococcus agalactiae (0.7%), and Corynebacterium spp. (0.4%). Antimicrobial resistance was higher (P > 0.01) to amoxicillin/clavulanic acid (AMC, 32.3%) than that to enrofloxacin (ENR, 23.4%), cefoperazone (CFP, 17.9%), cefquinome (CEQ, 17.7%), penicillin G (P, 15.2%), and gentamicin (CN, 3.6%) in culture-positive 642 isolates. For E. coli isolates, percentage of resistance to AMC, ENR, CFP, CEQ, P, and CN was 37.7, 30.6, 24.4, 23.2, 5.9, and 1.1%, respectively. Resistance to AMC (31.2%) and P (46.3%) was higher in CNS than Strep. dysgalactiae isolates (1.5% and 12.7%), respectively. Multidrug resistance was detected in 34 E. coli isolates (9.6%), 7 CNS isolates (8.6%), and 2 Strep. dysgalactiae (2.8%). In conclusion, the higher identification of E. coli demonstrated the higher risk of environmental microorganisms for CM in this study. Higher resistance to commonly used five of six antimicrobials showed the requirement of frequent bacteriological and antimicrobial susceptibility tests for CM. Thus, these implementations could increase treatment efficacy in cows and reduce antimicrobial resistance.
Molecular detection of Potential Novel Mansonella species (Filarioidea: Onchocercidae) in equine and Culicoides enderleini from Africa
Authors: Sadeddine R , Sambou M , Davoust B , Righi S , Daghri K , Benakhla A , Parola P , Mediannikov O 
Published: November 2024

A new genotype of a filarial worm from the Mansonella genus was determined in three donkeys from Algeria, as well as from four horses and two Culicoides enderleini biting midges from Senegal. Phylogenetic analysis based on the ITS1 and rRNA 5S genes shows similar results clustering this filarial worm within the genus Mansonella with low identity with all known Mansonella species. Further research should be performed to characterise this Mansonella sp. and assess its prevalence in African countries.
Effects of wheat and corn gluten on growth performance, histopathologic and autoimmune metabolism of entero-hepatictissue in lambs
Authors: Can MB , İmik H , Terim Kapakin KA 
Published: November 2024

This study investigated the effects of wheat gluten and corn gluten, alone as a protein source into rations as protein sources, on fattening performance and the histopathological and autoimmune metabolism of the small intestinal and hepatic tissues in lambs. The animals enrolled in the study were fed on isonitrogenous and isoenergetic diets. The protein sources provided to the animals were soybean meal and safflower meal in the control group, wheat gluten in Group Wheat, and corn gluten in Group Corn. The study animals included 24 male Morkaraman (Red Karaman) lambs, which were of a mean age of 9 months and assigned to three groups, each of 8 animals. Mean daily body weight gain (0-56 day) were observed to be significantly lower in Group Wheat (p<0.05). Mean daily feed intake were observed to be significantly lower in Group Wheat and Group Corn (p<0.05). At the end of the study, when compared to the control group, Group Wheat displayed significantly higher levels of villous atrophy, inflammation, crypt hyperplasia and transglutaminase immunopositivity in the small intestinal tissue as well as necrosis, inflammation, bile duct hyperplasia and transglutaminase immunopositivity in the hepatic tissue, and a lower level of degeneration in the liver (p<0.05). The findings detected in Group Corn were variable. In result, wheat gluten significantly affected both performance parameters and the histopathological and autoimmune metabolism of the intestinal and hepatic tissues in lambs.
Key words: Corn; gluten; lamb; wheat; histopathological
Análise da rede social de apoio de estudantes universitários na pandemia de Covid-19
Authors: Faria Magda Guimarães de Araujo , Silva Tarciso Feijó da , David Helena Maria Scherlowski Leal , Capulot Amanda Franco , Andrade Carolina Neves Dias de , Ramos Tatiana Cabral da Silva , Martins Neto Genes de Lima , Perri Ana Luiza da Silva 
Published: November 2024

Objetivo: identificar a rede social de apoio de estudantes de uma universidade pública brasileira durante o período de bloqueio da Covid-19. Método: estudo observacional, transversal baseado na análise de redes sociais. Os participantes foram estudantes de graduação de uma universidade. A coleta de dados ocorreu entre maio e dezembro de 2021 através de um formulário online. A análise foi realizada com o uso do software GephiⓇ. Resultados: participaram deste estudo, 969 indivíduos. Os maiores graus de centralidade foram encontrados respectivamente nas opções: família (0.572), os amigos (0.552) e mãe (0.551), entretanto, observou-se também a inserção de outros atores na rede, como a religião (0.074) e a figura do terapeuta (0.098). Considerações finais: espera-se que esta investigação possa subsidiar novos debates sobre o papel da universidade na manutenção da rede social de apoio dos estudantes, já que, mesmo em contexto de crise, a instituição não foi reconhecida COMO parte da rede estudantil.
Coherent mid-infrared vortex generation at room temperature for manipulation of microparticles
Authors: Mallick Nawaz Sarif 
Published: November 2024

We investigate the generation of mid-infrared (mid-IR) vortex beams carrying orbital angular momentum (OAM) through nonlinear processes in an inhomogeneously broadened 85Rb atomic ensemble. By employing a four-level atomic system featuring two strong control fields and a weak probe field, we generate a non-degenerate four-wave mixing signal at a wavelength of 5.23 µm. Applying the density-matrix formalism, we derive an analytical expression for the nonlinear atomic coherence which facilitates the transfer of vortex characteristics such as topological charge and intensity and phase profiles from the probe field to the mid-IR signal. Numerical solutions of Maxwell’s wave equation confirm the generation of mid-IR vortex beams with adjustable topological charges and beam widths at different spatial positions. This technique offers significant potential for applications in mid-IR communication, providing additional bandwidth and improved data transmission rates, as well as in fields such as microfluidics, biophysics, and nanotechnology, where OAM-carrying beams can manipulate microparticles with precision.
Association of the humoral immune response with the inflammatory profile in Plasmodium vivax infections in pregnant women
Authors: Souza Rodrigo Medeiros de , dos Santos Maria Inês , Gomes Laura Cordeiro , de Melo Bruna Beatriz Pedroza , Separovic Erika Paula Machado , Murillo Oscar , Wunderlich Gerhard , Clark Taane Gregory , Campino Susana , Epiphanio Sabrina , Marinho Claudio Romero Farias , Dombrowski Jamille Gregório 
Published: November 2024

Background
Plasmodium vivax infection, when it occurs during pregnancy, has often been associated with serious adverse pregnancy outcomes. However, immunological alterations in pregnancy and their consequences have been little explored. We characterized the humoral immune response in pregnant women exposed to malaria by P. vivax antigens and its association with the maternal inflammatory profile and poor pregnancy outcomes.

Methods
An observational cohort study in the Brazilian Amazon was conducted between 2013 and 2015. After applying exclusion criteria, 242 mother-child pairs were included in the analysis. Data on maternal infection, gestational outcomes, and inflammatory factors were evaluated in the maternal peripheral plasma. In samples from the first infection, the presence of total IgG and its subclasses in plasma against PvMSP119 protein were also quantified.

Results
Previous exposure to malaria, observed by anti-total IgG antibodies to the PvMSP119 antigen, increased the inflammatory response to infection when the pregnant woman had malaria during pregnancy. IL-6 and IL-10 levels were positively correlated with parasitemia and with total IgG levels; but they were negatively correlated with the gestational age at delivery from Pv-infected woman. In multivariate linear regression analyses, IgG 1, 2 and 4 was negatively and positively associated with cytokines IL-6 and IL-10, respectively, in P. vivax-infection.

Conclusions
An association between the humoral immune response and the peripheral inflammatory cytokine profile with the adverse outcomes in malaria in pregnancy by P. vivax was observed. Previous exposure to the parasite can influence the IL-6 and IL-10 response, which is associated with increased parasitemia, reduced maternal weight gain and premature delivery.
Sunlight exposure practice and its associated factors among infants in Ethiopia, systematic review and meta-analysis
Authors: Ayele Fanos Yeshanew , Kebede Natnael , Mekonen Asnakew Molla , Mihiretu Mengistu Mera , Tsega Yawkal , Addisu Elsabeth , Cherie Niguss , Birhane Tesfaye , Daba Chala , Asfaw Ahmed Hussien , Abegaz Zinet , Endawekie Abel , Mohammed Anissa , Melak Dagnachew , Bayou Fekade Demeke , Yasin Husniya , Zerga Aregash Abebayehu , Gebeyehu Fikre Bayu , Wagaye Birhanu 
Published: November 2024

Background
Lack of sunlight exposure is the primary reason for the worldwide epidemic of vitamin D deficiency. There was a meta-analysis conducted under the title of Knowledge and Practice of Mothers towards sunshine exposure of their children in Ethiopia. However, studies conducted on factors associated with sunlight exposure practice among infants showed non-conclusive and inconsistent findings. Hence, this systematic review and meta-analysis were conducted to estimate the pooled prevalence of good sunlight exposure practice and its associated factors among infants in Ethiopia.

Methods
All articles were systematically searched by PubMed, Hinari, Global Health and CINAHL, Epistemonikos, African Journal of Online (AJOL), Google Scholar and Google. All studies, until the end of May 30, 2023, were included in this review. Pure qualitative studies and studies in which the outcome was not reported were excluded from the review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline was used. Meta-analysis was conducted by using STATA 17 software. Forest plots were used to present the pooled prevalence of good sunlight exposure practices. A random effect model was used to compute the pooled prevalence, while subgroup analysis was performed to identify the possible source of heterogeneity. Publication bias was assessed by begg’s and Egger’s tests. We use Trim and fill analysis was used to treat the publication bias.

Results
This review involved 14 studies and 6,121 participants. The pooled prevalence of good sunlight exposure practice among infants in Ethiopia was 53.46% (95%CI: 45.98, 60.95). Mothers had PNC follow-up [OR = 2.22 (95% CI: 1.31, 3.47)], mothers with secondary and above educational status [OR = 4.17, (95% CI: 1.73, 10.06)], employed mothers [OR = 3.72, (95% CI: 2.71, 5.11)], urban residence [OR = 2.67, (95% CI: 1.17, 6.08)] and not fear of sunlight exposure [OR = 4.08, (95% CI: 1.44, 16.00)] were positively associated with good sunlight exposure practice.

Conclusions
The pooled prevalence of good sunlight exposure practices among infants in Ethiopia is low. Had postnatal care follow-up, being urban residents, mother’s employment status, mother’s educational status and not fear of sunlight exposure were independent factors of good sunlight exposure practice among infants. Therefore, health professionals create awareness for mothers to increase postnatal follow-up, and the importance of health education especially for rural residents.