bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bulgarian Experience with Adverse Drug Reaction Reports from Patients and Consumers – Retrospective Data-base Study
Authors: Getova Violeta I. , Georgiev Stanislav R. , Stoimenova Assena H. , Petkova-Georgieva Elina S. 
Published: October 2018

Abstract
Background: Since 2012, in compliance with the changes in the European legislation, the Bulgarian Drug Agency (BDA) has been receiving adverse drug reaction (ADR) reports directly from patients as well as from healthcare professionals and marketing authorization holders (MAH). Adverse reaction reports from patients and consumers have different characteristics from those sent by healthcare professionals. Moreover, they may require specific algorithm and assessment methods in order to be informative and beneficial to the pharmacovigilance system.
Aim: The study aims to analyze the data-base of consumer reports in Bulgaria in order to distinguish and classify the main characteristics of the ADR reports from non-healthcare professionals.
Materials and methods: In-depth analysis of the Bulgarian data-base of consumer ADR reports for 2012-2016 was conducted. The criteria include patient demographic characteristics, preferred method of reporting, seriousness and expectedness criteria and most frequently reported pharmacological groups.
Results: The data showed the current trends in patient reporting in the country. It also marked new courses for development of the spontaneous reporting system and collection of safety data. The analysis of the data-base showed a rather stable level of patient reporting with a tendency for constant growth every year. Bulgaria follows the world tendencies for high number of reports for insufficiently studied ADRs which meet the seriousness criteria. The review of the most frequently reported ATC codes could lead to the conclusion that the current pharmacovigi-lance methods are not sensitive enough for specific groups of medicines.
Conclusions: The results from the conducted study confirm the importance of patient reporting as a valuable source of information on adverse drug reactions. Moreover, it draws the attention to the lack of more sensitive methods for evaluation of drug safety in specific pharmacological groups. Maintenance of consumer-friendly ADR reporting system and innovative assessment algorithms should be the future directions for development in post-marketing surveillance.
Femoral Expandable Prosthesis In Bone Tumor of an Adult: A Case Report
Authors: Fenga Domenico , Rosa Michele A. 
Published: October 2018

Abstract
Management of bone tumors of the limbs is still a field to be explored. The problems to be faced are diff erent, especially when the lower limbs are the point of interest, due to the diff erent leg length residual.
A possible solution, provided by new technologies, is the use of electromagnetic expandable prosthesis. This device is successfully used in the management of paediatric malignant bone tumors. The strength of this prosthesis is the possibility to assist the musculoskeletal growth in children. To our acknowledge review of literature points out only few cases in which this mechanism is used in adult population. The authors present their results with expandable endoprosthetic replacement in an adult patient with severe lower limb discrepancy which occurred after a malignant bone tumor of the knee, obtaining a recovery of approximately 6 cm.
Alpha Lipoic Acid Influence in the Attenuation of Oxidative Stress and of Clinical Manifestations of Neuropathy in Diabetes Mellitus Patients
Authors: Cristian Bondar Andrei , Remus Popa Amorin 
Published: October 2018

Abstract
Alpha lipoic acid is an antioxidant substance used for the pathogenic treatment of diabetic neuropathy, oxidative stress being a central mechanism in diabetic microvascular complications. Our study included 24 diabetes mellitus patients with diabetic neuropathy and 20 healthy subjects. Diabetes patients were given alpha lipoic acid 600 mg intravenously for 10 days and then per os for 30 days.
Significant improvements were observed concerning oxidative stress evaluated by measuring serum malondyaldehide and ceruloplasmin. The clinical characteristic of neuropathy improved, both the level of pain decreased and the vibration perception threshold increased. Our study demonstrated a two times higher level of oxidative stress in patients with diabetes compared to healthy subjects, and that by influencing oxidative stress we could influence the clinical aspects of neuropathy. Further investigations need to be done to explore the pleiotropic effects of alpha lipoic acid on other mechanisms that are implicated in the pathogenies of diabetic neuropathy.
A Rare Neurological Complication - Posterior Reversible Encephalopathy Syndrome in a Patient with Systemic Lupus Erythematosus and Class IV Lupus Nephritis
Authors: Stroie Anna Mirela , Penescu Mircea Nicolae 
Published: October 2018

Abstract
Posterior reversible encephalopathy syndrome is a rare manifestation of systemic lupus erythematosus, characterized by altered mental status, headache, convulsions, visual field impairment and posterior and reversible alterations on imaging scans(1,2). The clinical picture develops over a few hours, presenting with rapidly progressive neurological symptoms(3). It was first described in 1996. It is more frequent in patients with acute kidney injury or chronic kidney disease, thus in lupus patients with kidney disorders. It is associated with hypertension, other autoimmune diseases beside lupus, immunosuppressive therapies, especially antibody-based immunosuppressive therapy, and organ transplantation. It is clinically reversible within one week and imaging changes resolve within 2-4 weeks. It is treatable and has a good prognosis. We present the case of a young woman of 27 years, diagnosed with systemic lupus erythematosus who developed convulsive seizures, headache, visual impairment, being under immunosuppressive therapy with azathioprine. The kidney biopsy revealed class IV lupus nephritis and partial remission of the nephrotic syndrome. The other manifestations of SLE in this patient were cutaneous, immunological, articular and haematological. The patient had a good short, medium and long-term prognosis at 30 days and also at 6 months.
Giant Left Atrial Myxoma Causing Mitral Valve Obstruction and Pulmonary Hypertension. A Case Report
Authors: Priscilla Pașc , Coţe Ioana Alexandra , Popescu Mircea Ioachim 
Published: October 2018

Abstract
Cardiac myxoma is the most common adult cardiac tumor, with an incidence of 1: 1,000,000 in the general population. Usually occurring between 4-6 decades of life, especially in women, most of the myxomas appear sporadically and are of unknown etiology. Rare cases are genetically determined. Sudden death can occur in 15% of cases. While papillary tumors often complicate coronary or systemic thromboembolism, solid tumors, ovoids, cause heart failure by obstructing the mitral orifice. From a clinical point of view, the atrial myxoma may mimic a valvulopathy, heart failure, dilatation cardiomyopathy, bacterial endocarditis, and may cause heart rhythm disorders, syncope, myocardial infarction and systemic or pulmonary thromboembolism. I will present the case of a giant atrial myxoma, intermittent obstructive of the mitral orifice, evolving towards global heart failure. The lack of severe acute complications during the most likely long-lasting evolution represents an undiscovered curiosity.
El colectivismo agrario como utopía popular: la propiedad de la tierra en Joaquín Costa
Authors: López Forjas Manuel 
Published: October 2018

En este artículo, se presenta el colectivismo agrario como una filosofía sobre la propiedad de la tierra según la obra del pensador y político aragonés Joaquín Costa (1846-1911). En primer lugar, se intenta subrayar la importancia del carácter utópico en los proyectos intelectuales y políticos de Costa, como un contexto para entender el colectivismo agrario. En segundo lugar, se propone una lectura desde sus primeros textos juveniles hasta sus años universitarios, siguiendo sus reflexiones sobre la propiedad de la tierra. Finalmente, se trata una de sus obras de madurez Colectivismo agrario en España como la conjugación de esos textos, haciendo un análisis en particular de las doctrinas que dan cuenta de una recepción y crítica de la Utopía de Tomás Moro; con el objetivo de acercarse más al conocimiento de su proyecto político.
Iododerma after radioiodine therapy in CA thyroid: a case report
Authors: Rubab Nayyar , Gillani Farkhanda , Imran M. Babar , Naeem Muhammad , Akhtar Muhammad Saeed 
Published: October 2018

Background:
Iodine-131 (I-131) therapy is a well-established method for the treatment of differentiated thyroid cancer [carcinoma (CA)]. Following such therapy, patients may experience complications classified as early/intermediate or delayed side effects. We report an unusual side effect after oral I-131 therapy in the form of a skin eruption (iododerma).

Case Presentation:
We describe a case of a 60-year-old female, presented with pustular lesions all over skin after radioiodine therapy for CA thyroid. On the basis of history and clinical examination, diagnosis of iododerma was made.

Conclusion:
Iododerma is a very rare complication of radioiodine therapy. When pustular lesions develop after radioiodine therapy, iododerma should be kept in mind after the exclusion of other differentials. It appears within 4–6 weeks after therapy and is a self-limiting condition.
Unusual electrocardiographic changes in a patient with pericardial effusion caused by rheumatoid arthritis: a case report
Authors: Cocco Giuseppe 
Published: October 2018

Background:
Rheumatoid arthritis (RA) is an immune-related inflammatory disease which affects almost 1% of the general population and which is ranked among the top 15% of diseases causing major disability worldwide. RA shares some pathologic features, genetic predisposition, and risk factors with atherosclerosis, and inflammation plays a central pathophysiologic role in both diseases. RA is associated with an increased risk of cardiovascular mortality. In RA, pericardial involvement is a frequent complication but rarely occurs as the first manifestation.

Case Presentation:
A 63-year-old male patient with RA presented with an acute chest pain and in the Electrocardiography (ECG) ischemic ST-down-sloping in multiple leads. Echocardiography showed an abnormal “bounce” of the interventricular septum and a small-medium size pericardial effusion. The laboratory values showed high inflammatory parameters and confirmed the presence of active RA. Troponin T was normal and NT-proBNP was at level 2. There were no signs for vasculitis. Coronarography found only small non-stenotic changes in the coronary arteries. A rheumatologic consultant recommended prednisone and later on, tocilizumab. He was also treated with colchicine. The clinical condition improved within 2 weeks and the ECG changes normalized within a month. Three months later, an echocardiographic follow-up showed that the pericardial effusion and the left ventricular bounce had disappeared.

Conclusion:
Small-medium size pericardial effusion manifesting as an acute coronary syndrome and with ischemic ECG changes is the most unusual finding. Indeed, the proper diagnosis of a pericardial effusion was made retrospectively
Impact of vitamin D on rheumatoid arthritis: real or just patient’s perception?
Authors: ÇALIŞKAN UÇKUN Aslı , YURDAKUL Fatma Gül , KILIÇARSLAN Ayşegül , BAŞKAN Bedriye , SİVAS Filiz , DURAN Semra , BODUR Hatice 
Published: October 2018

Aim: In this study, our aims were to identify
vitamin D levels in rheumatoid arthritis (RA) individuals as compared to
controls and the impact of vitamin D levels on both objective and subjective
assessments in RA patients. Methods: The current study was a prospective
case-control study conducted
on 108 RA patients and 50 age-gender matched healthy controls. We first
compared the levels of vitamin D among the RA patients and controls.
Demographic and clinical data, parameters of disease activity, inﬂammatory
markers, rheumatoid factor and anti-cyclic citrullinated peptide seropositivity
and radiological damage scores were recorded in RA patients. These patients
were also demanded to complete RA Quality of Life Questionnaire (RAQoL),
fatigue severity scale (FSS) and Health
Assessment Questionnaire (HAQ).Results: D vitamin levels in RA patients were
significantly lower than healthy controls (p=0.001). Vitamin D deficiency was
determined in 73% of the RA patients and 52% of the controls. Vitamin D
deficiency was not associated with disease activity (p=0.862). There was no
significant relationship among vitamin D levels and all subjective and
objective assessments (p&gt;0.05 for all ).

Conclusion: Vitamin D deficiency was common in
RA participants than normal population. However, it was not shown that there
was a significant relationship between vitamin D levels and objective and
subjective assessments of disease, including disease activity, inflammatory markers,
rheumatoid factor and anti-cyclic citrullinated peptide seropositivity,
radiological damage scores, RAQoL, FSS and HAQ.
El derecho a la educación de los estudiantes de medicina durante el internado rotatorio
Authors: Vázquez-Martínez Francisco Domingo 
Published: October 2018

Las facultades de medicina deben garantizar el derecho a la educación de los estudiantes cualquiera que sea el escenario educativo. ¿Se respeta el derecho a la educación de los estudiantes de medicina en las unidades de atención médica durante el internado rotatorio? MÉTODO. 97 de 110 estudiantes de la Universidad Veracruzana que terminó el internado (diciembre 2017) contestaron un cuestionario de percepción del respeto a su derecho a la educación durante el mismo. RESULTADOS. 47% de encuestados considera que hubo un respeto medio a su derecho a la educación; 95% se sintió como fuerza de trabajo; 32% nunca cometió errores clínicos por falta de supervisión y 20% siempre recibió atención por parte de sus profesores de la facultad. CONCLUSIONES. El respeto al derecho a la educación de los internos puede mejorar significativamente, lo que conllevará a un mayor derecho a la salud en México.Palabras clave: Educación médica; internado rotatorio de pregrado; derecho a la educación; derecho a la salud; seguridad del paciente AbstractBACKGROUND. The schools of medicine have to guarantee the rights to edu­cation to students regardless of the educational setting. Is the right to education to medical stu­dents at the health care units during the rota­ting internship respected? METHODS. 97 out of 110 students from Universidad Veracruzana (University of Veracruz), who completed the internship (December 2017), answered a ques­tionnaire regarding their perception whether their rights to education was respected during the internship. RESULTS. 47% of respondents considered that their rights to education had a medium level of respect; 95% felt they were considered as a work force; 32% never made any clinical errors due to lack of supervision, while 20% was always paid attention by their faculty professors. CONCLUSIONS. Respecting the right to edu­cation to internists can be significantly impro­ved, which will lead to a greater right to health in Mexico.Keywords: Public observation; violence; justi­ce; vulnerability; public policy
Oxisteroles: entre la salud y la enfermedad
Authors: Soto Rodríguez Ida , Ramos Manuel Luis Enrique , Barrientos Salcedo Carolina 
Published: October 2018

El colesterol es un esteroide de origen animal que cumple numerosas funciones metabólicas, es un precursor de ácidos biliares, de los esteroles fecales, de la vitamina D y de las hormonas esteroideas. Este esteroide es sintetizado en el hígado y otros tejidos, y puede ser absorbido a través de alimentos que se encuentran en nuestra dieta. Tiene una doble ligadura susceptible de oxidarse formando oxiesteroles. No obstante que se encuentran en pequeñas concentraciones son moléculas versátiles porque participan en diversas funciones metabólicas, favorecen algunas patologías ó regulan la expresión de los genes. La intervención de los oxiesteroles en la aterosclerosis es la patología más estudiada, aunque también se ha estudiado su participación en enfermedades neurodegenerativas como el Alzheimer. A partir de la manipulación genética in vivo, así como el uso de simulaciones por ordenadores, se podrá comprender cómo los oxiesteroles gobiernan la señalización celular, modulan la expresión génica, e influyen en nuestra salud o enfermedad.Palabras clave: Colesterol; esteroide; oxiesteroles; aterosclerosis; Alzheimer AbstractCholesterol is a steroid of animal origin that meets numerous metabolic functions, is a pre­cursor of bile acids, fecal sterols, vitamin D and steroid hormones. This steroid is synthesized in the liver and other tissues, and can be absorbed through foods that are found in our diet. It has a double ligature susceptible to oxidizing forming oxysterols. Nevertheless they are found in slight concentrations are versatile molecules because they participate in diverse metabolic functions, they advantage some pathologies or they regulate the expression of the genes. The intervention of oxysterols in atherosclerosis is the most studied pathology, although its parti­cipation in neurodegenerative diseases such as Alzheimer’s has also been studied. So that the novel analytical tools will promote the study of oxysterols health or illness.Keywords: Cholesterol, steroid, oxysterols, atherosclerosis, Alzheimer
Perspectivas para el estudio del bienestar: Observatorio de Calidad de Vida y Salud Social
Authors: Beltrán Guerra León Felipe , Arellanez Hernández Jorge Luis , Romero Pedraza Enrique 
Published: October 2018

En el presente trabajo se presenta la propuesta del Observatorio de Calidad de Vida y Salud Social de la Universidad Veracruzana, que -desde los planteamientos de la ONU contenidos en los Objetivos del Desarrollo Sostenible; en el Programa de las Naciones Unidas para el Desarrollo así como diversos estudios del Desarrollo Humano- utiliza una perspectiva multidimensional para abordar los estudios sobre bienestar, desde, con el fin de sistematizar información que contribuya a la toma de decisiones para incidir en la mejora de las condiciones de bienestar y salud social en México.Palabras clave: bienestar; bienestar subjetivo; calidad de vida; salud social; condiciones de vida AbstractPresent work presents the proposal of the Observatory of Quality of Life and Social Health of the Universidad Veracruzana, which -from the proposals of the UN contained in the Sustaina­ble Development Goals; in the United Nations Development Program as well as various studies of Human Development - uses a multidimensional perspective to address welfare studies, in order to systematize information that contributes to decision making to influence the improve­ment of the conditions of welfare and social health in Mexico.Keywords: wellbeing; subjective wellbeing; quality of life; social healt; life conditions
Structural, optical and electrical properties of thermal evaporated nano sized In2Te3 thin films
Authors: R Revathi , R Karunathan 
Published: October 2018

Indium Telluride thin films were prepared by thermal evaporation technique. Films were annealed at 573K under vacuum for an hour. Both as-deposited and annealed films were used for characterization. The structural parameters were discussed on the basis of annealing effect for a film of thickness 1500 Å. Optical analysis was carried out on films of different thicknesses for both as - deposited and annealed samples. Both the as- deposited and annealed films exhibit direct and allowed transition. Electrical resistivity measurements were made in the temperature range of 303-473 K using Four-probe method. The calculated resistivity value is of the order of 10-6 ohm meter. The activation energy value decreases with increasing film thickness. The negative temperature coefficient indicates the semiconducting nature of the film.
Reseñas
Authors: Pedraza Gracia Manuel José , Gioia Tavoni Maria , Bas Martín Nicolás , Carpallo Bautista Antonio 
Published: October 2018

Manuel José Pedraza Gracia = Incunabula universitatis: los incunables de las bibliotecas universitarias españolas. Edición a cargo de Ramón Rodríguez Álvarez. Oviedo, Universidad de Oviedo, 2015. 313 p. ISBN: 978-84-16046-82-9.
Maria Gioia Tavoni = Atti del convegno Incunabula. Printing, Trading, Collecting, Cataloguing, 10-12 settembre 2013, La Bibliofilia, 116, n. 1/3 (2014). ISSN 0006-0941.
Nicolás Bas Martín = Rosa M. GREGORI ROIG, La impressora Jerònima Galés i els Mey (València, segle XVI), Valencia, Biblioteca Valenciana, 2012. 611 p. ISBN 978-84-482-5722-4.
Nicolás Bas Martín = Juan GOMIS COLOMA, Menudencias de imprenta. Producción y circulación de la literatura popular (Valencia, siglo XVIII), Valencia, Institució Alfons el Magnànim, 2015. 557 p. ISBN 978-84-7822-2015.
Antonio Carpallo Bautista = José Luis GONZALO SÁNCHEZ-MOLERO, Leyendo a Edo. Madrid, Consejo Superior de Investigaciones Científicas, 2013, 163 p. ISBN: 978-84-00-09660-1.
Удосконалення діагностики післяопераційних атрофічних та нормотрофічних рубців шкіри шляхом застосування колірної системи RGB
Authors: Avetikov D. S. , Bukhanchenko O. P. , Stavitsky S. O. , Ivanytska O. S. , Scrypnyk V. M. 
Published: October 2018

Мета. Удосконалення методів диференціальної діагностики атрофічних та нормотрофічних рубців шкіри голови та шиї шляхом використання комп’ютерної візуалізації цифрових світлин із застосуванням колірної системи RGB (Red, Green, Blue).
Матеріали і методи. Ми спостерігали 60 пацієнтів із післяопераційними рубцями шкіри голови та шиї. Рубцевозмінену тканину додатково обстежували, аналізуючи цифрові світлини у програмі Adobe Photoshop CC із використанням системи кольорів RGB.
Результати. Застосовуючи колірну систему RGB у діагностиці післяопераційних рубців шкіри щелепно-лицевої ділянки, достовірно визначали тип рубця. Залежно від типу рубця обирали оптимальний метод хірургічного втручання або консервативної терапії.
Висновки. Застосування системи кольорів RGB у програмі Adobe Photoshop СС дає можливість диференціювати атрофічні та нормотрофічні рубці шкіри за показниками інтенсивності забарвлення кольоровим спектром.
Динамика энергоструктурной активности при ингаляционной анестезии
Authors: Boitsova O. N. , Smirnova L. M. , Shifrin G. A. 
Published: October 2018

Цель. Улучшение результатов лечения больных путем придания периоперационному обеспечению ингаляционной анестезии севофлураном энергопротективной направленности.
Материалы и методы. У пациентов с острой патологией органов брюшной полости проведен аудит энергоструктурной активности во время ингаляционной анестезии севофлураном. В группе сравнения использовали общепринятый протокол, в основной – с применением органопротективных технологий. Определяли клинические индексы опасности (КИО), безопасности (КИБ), кардиальный резерв (КР), микроциркуляторно–митохондриальную недостаточность (ММН), концентрацию в крови нейроглиального белка (S100) и нейронспецифической энолазы (NSE).
Результаты. Ингаляционная анестезия севофлураном нарушает энергоструктурные взаимодействия (ЭСВ) в массе клеток тела (МКТ). Энергопротективные технологии снижают степень повреждения, о чем свидетельствовала концентрация в крови S100 и NSE.
Выводы. Применение энергопротективных технологий в соответствии с категориями энергоструктурной активности в МКТ позволяет улучшить результаты лечения пациентов с острой патологией брюшной полости и персонифицировать анестезиологическое обеспечение. Выявлена и доказана тесная корреляционная связь между ранними проявлениями структурных микроповреждений клеток головного мозга с энергоструктурными изменениями в МКТ пациентов.