bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-Dimensional Topography of the Emerging Point of the Ophthalmic Artery
Authors: Cong Li-Yao , Choi You-Jin , Hu Kyung-Seok , Tansatit Tanvaa , Kim Hee-Jin 
Published: October 2018

Background:
During periorbital noninvasive and surgical procedures, there is the risk of iatrogenic injury to the emerging point of the ophthalmic artery. This study aimed to determine the three-dimensional location of the emerging point of the ophthalmic artery and to provide clinicians with anatomical information that would help them to avoid associated complications.

Methods:
Seventeen hemifaces of the emerging point of the ophthalmic artery from 10 Korean and seven Thai cadavers were dissected and scanned by a three-dimensional scanner. The emerging points of the ophthalmic artery of 30 healthy Korean volunteers were also detected using an ultrasound imaging system.

Results:
The transverse distance from the medial canthus to the emerging of the ophthalmic artery was 3.8 ± 1.0 mm medially, and the vertical distance was 14.0 ± 2.9 mm superiorly. The transverse distance from the midline was 16.5 ± 1.7 mm to the emerging point of the ophthalmic artery and 20.0 ± 2.0 mm to the medial canthus. The measured depth from the skin surface to the emerging point of the ophthalmic artery was 4.8 ± 1.7 mm by means of three-dimensional scanning and 4.5 ± 1.1 mm using ultrasound detection. The vertical distance from the inferior margin of the superior orbital rim to the emerging point of the ophthalmic artery was 5.3 ± 1.4 mm.

Conclusion:
These data inform clinicians about the anatomical three-dimensional location of the emerging point of the ophthalmic artery, which will help them to avoid iatrogenic injury when they are performing periorbital clinical procedures.
Comparative Study of Choke Vessel Reconstruction With Single and Multiple Perforator–Based Flaps on the Murine Back Using Delayed Surgery
Authors: Mao Yihua , Li Hong , Ding Maochao , Hao Xiaodi , Pan Jing , Tang Maolin , Chen Shixin 
Published: October 2018

Objective
Choke vessels, vascular anastomosis between adjacent angiosome, play an important role in flap expansion and survival. Here we established a flap model with single and multiple perforators to detect and compare the changes in choke vessels, discuss the effect of hemodynamics on the vascular morphology, and explore the underlying mechanism.

Methods
One hundred mice (7–8 weeks) were subjected to a “choke zone” surrounded by 4 perforators on their backs. Delayed surgery was performed by the ligation of 1, 2, or 3 perforators to establish flap models. The blood flow of the choke zone was measured by laser Doppler flowmetry preoperatively and 6 hours and 1, 3, 5, and 7 days. The morphological changes of choke vessels in the choke zone were observed by gross and histological analyses. Levels of angiogenesis-related markers such as endothelial nitric oxide synthase (eNOS), metalloproteinase 2, hypoxia-inducible factor 1α (HIF-1α), and intercellular adhesion molecule 2 (ICAM-2) were detected by Western blotting and enzyme-linked immunosorbent assay.

Results
Blood flow and microvascular count were obviously increased postoperatively and peaked and were maintained for 1 week (P < 0.01). Meanwhile, the diameters of the choke vessels expanded. The eNOS level was increased at 7 days (P < 0.05); however, the enzyme-linked immunosorbent assay results showed that the HIF-1α and ICAM-2 levels were decreased at 7 days.

Conclusions
(1) The delayed surgery that kept a single perforator had the greatest impact on the choke zone. (2) Changes in choke vessels were closely related to the shear stress caused by enhanced blood perfusion after surgery. (3) Choke vessel growth was regulated by eNOS, metalloproteinase 2, HIF-1α, and ICAM-2.
Pedicled Thoracodorsal Artery Perforator and Muscle-Sparing Latissimus Dorsi Flaps in the Axillary Reconstruction After Hidradenitis Suppurativa Excision
Authors: Marchesi Andrea , Marcelli Stefano , Zingaretti Nicola , Parodi Pier Camillo , Vaienti Luca 
Published: October 2018

Background
Wide axillary reconstruction after hidradenitis suppurativa (HS) excision still represents a great challenge. Thoracodorsal artery perforator flap is one of the most reliable local reconstructive techniques. Although its anatomy and harvesting technique have been well described, specific reconstructive criteria still lack. The aim of this study was to help surgeons in planning axillary reconstruction on flaps based on the thoracodorsal artery.

Methods
Twelve patients affected by HS at Hurley stage III underwent wide “en block” excision and immediate reconstruction with 15 local thoracodorsal artery perforator flaps and 2 muscle-sparing latissimus dorsi flaps. A thorough chart review has been performed with preoperative and postoperative photographic documentations. Early and late complications have been analyzed.

Results
A total of 15 perforator flaps on thoracodorsal artery and 2 muscle-sparing latissimus dorsi flaps have been raised. The early complication rate was 29%, whereas the late complication rate was 35%. Except for one, all patients declared they were satisfied or highly satisfied from both aesthetic and functional points of view. Analyzing specific aspects, we have described several important details to consider for the reconstruction of the axilla. Through a retrospective analysis, we have classified HS axillary patients into 4 categories to better plan surgical reconstruction.

Conclusions
Axillary reconstruction is still a plastic surgery challenge. Peculiar surgical details should be considered when approaching this area. This new classification may help young surgeons during the reconstructive phase.
C/VDdb: a multi-omics expression profiling database for a knowledge-driven approach in cardiovascular disease (CVD)
Authors: Fernandes Marco , Patel Alisha , Husi Holger 
Published: October 2018

AbstractThe cardiovascular disease (C/VD) database is an integrated and clustered information resource that covers multi-omic studies (microRNA, genomics, proteomics and metabolomics) of cardiovascular-related traits with special emphasis on coronary artery disease (CAD). This resource was built by mining existing literature and public databases and thereafter manual biocuration was performed. To enable integration of omic data from distinct platforms and species, a specific ontology was applied to tie together and harmonise multi-level omic studies based on gene and protein clusters (CluSO) and mapping of orthologous genes (OMAP) across species.CAD continues to be a leading cause of death in the population worldwide, and it is generally thought to be an age-related disease. However, CAD incidence rates are now known to be highly influenced by environmental factors and interactions, in addition to genetic determinants. With the complexity of CAD aetiology, there is a difficulty in research studies to elucidate general elements compared to other cardiovascular diseases.Data from 92 studies, covering 13945 molecular entries (4353 unique molecules) is described, including data descriptors for experimental setup, study design, discovery-validation sample size and associated fold-changes of the differentially expressed molecular features (p-value<0.05). A dedicated interactive web interface, equipped with a multi-parametric search engine, data export and indexing menus are provided for a user-accessible browsing experience.The main aim of this work was the development of a data repository linking clinical information and molecular differential expression in several CVD-related traits from multi-omics studies (genomics, transcriptomics, proteomics and metabolomics). As an example case of how to query and identify data sets within the database framework and concomitantly demonstrate the database utility, we queried CAD-associated studies and performed a systems-level integrative analysis.URL:www.padb.org/cvd
Testing the unitary theory of language lateralisation using functional transcranial Doppler sonography in adults
Authors: Woodhead ZVJ , Bradshaw AR , Wilson AC , Thompson PA , Bishop DVM 
Published: October 2018

AbstractCerebral lateralisation for language can vary from task to task, but it is unclear if this reflects error of measurement or independent lateralisation of different language systems. We used functional transcranial Doppler sonography to assess language lateralisation in 37 adults (7 left-handers) on six tasks, each given on two occasions. Tasks taxed different aspects of language function. A preregistered structural equation analysis was used to compare models of means and covariances. For most people, a single lateralised factor explained most of the covariance between tasks. A minority, however, showed dissociation of asymmetry, giving a second factor. This was mostly derived from a receptive task, which was highly reliable but not lateralised. The results suggest that variation in strength of language lateralisation reflects true individual differences and not just error of measurement. Inclusion of several tasks in a laterality battery makes it easier to detect cases of atypical asymmetry.
Selene: a PyTorch-based deep learning library for biological sequence-level data
Authors: Chen Kathleen M. , Cofer Evan M. , Zhou Jian , Troyanskaya Olga G. 
Published: October 2018

AbstractTo enable the application of deep learning in biology, we present Selene (https://selene.flatironinstitute.org/), a PyTorch-based deep learning library for fast and easy development, training, and application of deep learning model architectures for any biological sequences. We demonstrate how Selene allows researchers to easily train a published architecture on new data, develop and evaluate a new architecture, and use a trained model to answer biological questions of interest.
Interactions between N-Terminal Modules in MPS1 Enable Spindle Checkpoint Silencing
Authors: Pachis Spyridon T. , Hiruma Yoshitaka , Perrakis Anastassis , Kops Geert J.P.L. 
Published: October 2018

ABSTRACTFaithful chromosome segregation relies on the ability of the spindle assembly checkpoint (SAC) to delay anaphase onset until all chromosomes are attached to the mitotic spindle via their kinetochores. MPS1 kinase is recruited to unattached kinetochores to initiate SAC signaling, and is removed from kinetochores once stable microtubule attachments have been formed to allow normal mitotic progression. Here we show that a helical fragment within the kinetochore-targeting NTE module of MPS1 is required for interactions with kinetochores, and also forms intramolecular interactions with its adjacent TPR domain. Bypassing this NTE-TPR interaction results in high MPS1 levels at kinetochores due to loss of regulatory input into MPS1 localization, ineffecient MPS1 delocalization from kinetochores upon microtubule attachment, and SAC silencing defects. These results show that SAC responsiveness to attachments relies on regulated intramolecular interactions in MPS1 and highlight the sensitivity of mitosis to perturbations in the dynamics of the MSP1-NDC80-C interactions.
Chronic, Low-Level Oral Exposure to Marine Toxin, Domoic Acid, Alters Whole Brain Morphometry in Nonhuman Primates
Authors: Petroff Rebekah , Richards Todd , Crouthamel Brenda , McKain Noelle , Stanley Courtney , Grant Kimberly S. , Shum Sara , Jing Jing , Isoherranen Nina , Burbacher Thomas M. 
Published: October 2018

ABSTRACTDomoic acid (DA) is an excitatory neurotoxin produced by marine algae and responsible for Amnesiac Shellfish Poisoning in humans. Current regulatory limits (~0.075-0.1 mg/kg/day) protect against acute toxicity, but recent studies suggest that the chronic consumption of DA below the regulatory limit may produce subtle neurotoxicity in adults, including decrements in memory. As DA-algal blooms are increasing in both severity and frequency, we sought to better understand the effects of chronic DA exposure on reproductive and neurobehavioral endpoints in a preclinical nonhuman primate model. To this end, we initiated a long-term study using adult, female Macaca fascicularis monkeys exposed to daily, oral doses of 0.075 or 0.15 mg/kg of DA for a range of 321-381, and 346-554 days, respectively. This time period included a pre-pregnancy, pregnancy, and postpartum period. Throughout these times, trained data collectors observed intentional tremors in some exposed animals during biweekly clinical examinations.The present study explores the basis of this neurobehavioral finding with in vivo imaging techniques, including diffusion tensor magnetic resonance imaging and spectroscopy. Diffusion tensor analyses revealed that, while DA exposed macaques did not significantly differ from controls, increases in DA-related tremors were negatively correlated with fractional anisotropy, a measure of structural integrity, in the internal capsule, fornix, pons, and corpus callosum. Brain concentrations of lactate, a neurochemical closely linked with astrocytes, were also weakly, but positively associated with tremors. These findings are the first documented results suggesting that chronic oral exposure to DA at concentrations near the current human regulatory limit are related to structural and chemical changes in the adult primate brain.
PSMA Expression in the Hi-Myc Model; Extended Utility of a Representative Model of Prostate Adenocarcinoma for Biological Insight and as a Drug Discovery Tool
Authors: Simons Brian W. , Turtle Norman F. , Ulmert David H. , Abou Diane S. , Thorek Daniel L.J. 
Published: October 2018

AbstractProstate specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is highly overexpressed in primary and metastatic prostate cancer (PCa). This has led to the development of radiopharmaceuticals for targeted imaging and therapy under current clinical evaluation. Despite this progress, the exact biological role of the protein in prostate cancer development and progression has not been fully elucidated. This is in part because the human PSMA and mouse PSMA (mPSMA) have different patterns of anatomical expression which confound study in the most widely utilized model organisms. Most notably, mPSMA is not expressed in the healthy murine prostate. Here, we reveal that mPSMA is highly upregulated in the prostate and prostate adenocarcinoma in the spontaneous Hi-Myc mouse model, a highly accurate and well characterized mouse model of prostate cancer development. Antibody detection and molecular imaging tools are used to confirm that mPSMA is expressed from early prostatic intraepithelial neoplasia (PIN) through adenocarcinoma.
Novel use of Diffusion Tensor Imaging to Delineate the Rat Basolateral Amygdala
Authors: Obenaus Andre , Kinney-Lang Eli , Jullienne Amandine , Haddad Elizabeth , Shereen Duke , Solodkin Ana , Dunn Jeffery F. , Baram Tallie Z. 
Published: October 2018

AbstractThe amygdaloid complex, including the basolateral nucleus (BLA) contributes crucially to emotional and cognitive brain functions, and is thus a major target of research in both humans and rodents. However, delineating structural amygdala plasticity in both normal and disease-related contexts using neuroimaging has been hampered by the difficulty of unequivocally identifying the boundaries of the BLA. This challenge is a result of poor contrast between BLA and the surrounding gray matter, including other amygdala nuclei. Here we describe a novel DTI approach to enhance contrast, enabling optimal identification of BLA in rodent brain from MR images. We employed this methodology together with a slice-shifting approach to measure BLA volume. We then validated the results by direct comparison to both histological and cellular-identity (parvalbumin)-based conventional techniques for defining BLA in the same brains used for MRI. We also confirmed the BLA region using DTI based tractography. The novel approach used here enables accurate and reliable delineation of BLA. Because this nucleus is involved in, and is changed by, developmental, degenerative and adaptive processes, the instruments provided here should be highly useful to a broad range of neuroimaging studies. Finally, the principles used here are readily applicable to numerous brain regions and across species.Summary StatementUse of MRI directionally encoded diffusion tensor imaging (DTI) can delineate the basolateral amygdala (BLA) and volumes derived from DTI were found to match those obtained using histological methods. Our approach can be used to identify the BLA.
Musical interaction is influenced by underlying predictive models and musical expertise
Authors: Heggli Ole A. , Konvalinka Ivana , Kringelbach Morten L. , Vuust Peter 
Published: October 2018

AbstractMusical interaction is a unique model for understanding humans’ ability to align goals, intentions, and actions, which also allows for the manipulation of participants’ internal predictive models of upcoming events. Here we used polyrhythms to construct two joint finger tapping tasks that even when rhythmically dissimilar resulted in equal inter-tap intervals (ITIs). Thus, behaviourally a dyad of two musicians tap isochronously at the same rate, yet with their own distinct rhythmical context model (RCM). We recruited 22 highly skilled musicians (in 11 dyads) and contrasted the effect of having a shared versus non-shared RCM on dyads’ synchronization behaviour. As expected, tapping synchronization was significantly worse at the start of trials with non-shared models compared to trials with a shared model. However, the musicians were able to quickly recover when holding dissimilar predictive models. We characterised the directionality in the tapping behaviour of the dyads and found patterns mostly of mutual adaptation. Yet, in a subset of dyads primarily consisting of drummers, we found significantly different synchronization patterns, suggesting that instrument expertise can significantly affect synchronization strategies. Overall, this demonstrates that holding different predictive models impacts synchronization in musicians performing joint finger tapping.Public significance statementThis study shows that when a pair of musicians thinks differently about a rhythm they play together, their performance is worse. However, they are able to recover back to normal performance levels after a few taps for which they use different strategies. Interestingly, we find that the strategies used by drummers may be different from other musicians.
How to foster innovative culture and capable champions for Chinese firms
Authors: Lei Hui , Phouvong Sengphet , Le Phong Ba 
Published: October 2018

PurposeThis paper aims to provide more knowledge on antecedent conditions of organizational capacity for change by examining the mediating role of employee trust in relationship between transformational leadership (TL) and two components of organizational change capacity (OCC) (innovative culture and capable champions) in Chinese firms.Design/methodology/approachSurvey data were collected from 269 participants at 65 Chinese firms. Structural equation modeling was used to test hypotheses in the proposed research model.FindingsThe research findings indicate that within the Chinese context, TL and two dimensions of employee trust in leadership (cognition-based trust and affect-based trust) are positively related to innovative culture and capable champions. Moreover, the two dimensions of employee trust act as the mediating roles between TL and components of OCC.Research/limitations implicationsThe results and benchmarks in this paper are appropriate for a particular context of Chinese firms. Future research should examine other contexts to provide a clearer picture of the relationship between the constructs.Practical implicationsThe study highlights the importance of practicing TL style to build employee trust in leadership aimed at fostering innovative culture and capable champions.Originality/valueThe paper has provided theoretical and managerial initiatives in the field of organizational behavior and change management that can clarify the relationship between TL, employee trust and OCC. These initiatives might help firms to identify a right pathway for promoting OCC and adapting more quickly and effectively to the change of business environment.
Open educational resources (OERs) in self-directed competency-based education
Authors: Horn Eileen A. , Anderson Ryan , Pierick Kristine 
Published: October 2018

Purpose
This study aims to describe how open educational resources (OERs) were used in a system-wide, competency-based higher education program. It discusses barriers encountered, solutions developed and suggestions for future research on OER-focused curricula for self-directed learners. The case demonstrates practical application of the best practices for OER usage and contributes to discussions among the open education community about what constitutes quality OERs and how quality measures can help instructors select the best available OER.

Design/methodology/approach
This case study uses a reflective approach to describe what the organization did to facilitate OER use in University of Wisconsin Flexible Option. The authors reflect on tools and processes used and highlight alignment with best practices from OER literature.

Findings
This case confirms that there are challenges associated with OERs, especially for faculty with limited experience using them. It also offers insights into how to evaluate and curate OERs and confirms that students are generally satisfied when OERs are used as primary learning resources.

Research limitations/implications
Formal research was not conducted. This case provides a starting point for potential future research about the use of OERs by self-directed, competency-based students.

Practical implications
Practical implications of this case study include concrete tools and methods faculty and instructional designers can use to locate, evaluate and curate OERs. This case study highlights the role OERs can play in increasing overall satisfaction with learning resources while decreasing students’ costs.

Originality/value
This case ties unique needs of self-directed, competency-based learners with the use of OERs, addressing two overarching questions about OERs: what constitutes a quality OER? and how is quality measured?
Effect of Lean Six Sigma on quality performance in Malaysian hospitals
Authors: Ahmed Selim , Abd Manaf Noor Hazilah , Islam Rafikul 
Published: October 2018

PurposeThe purpose of this paper is to investigate the effects of Lean Six Sigma (LSS) and workforce management on the quality performance of Malaysian hospitals. This paper also investigates the direct and indirect relationships between top management commitment and quality performance of the healthcare organisations in Malaysia.Design/methodology/approachThis study applied stratified random sampling to collect data from 15 different hospitals in Peninsular Malaysia. The self-administered survey questionnaires were distributed among 673 hospital staff (i.e. doctors, nurses, pharmacists, and medical laboratory technologists) to obtain 335 useful responses with a 49.47 per cent valid response rate. The research data were analysed based on confirmatory factor analysis and structural equation modelling by using AMOS version 23 software.FindingsThe research findings indicated that LSS and workforce management have a significant impact on quality performance of the Malaysian hospitals, whereas senior management commitment was found to have an insignificant relationship with quality performance. The research findings indicate that senior management commitment has no direct significant relationship with quality performance, but it has an indirect significant relationship with quality performance through the mediating effects of LSS and workforce management.Research limitations/implicationsThis research focussed solely on healthcare organisations in Malaysia and thus the results might not be applicable for other countries as well as other service organisations.Originality/valueThis research provides theoretical, methodological, and practical contributions for the LSS approach and the research findings are expected to provide guidelines to enhance the level of quality performance in healthcare organisations in Malaysia as well as other countries.