bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wogonoside impedes the progression of acute myeloid leukemia through inhibiting bone marrow angiogenesis
Authors: Lin Binyan , Zhao Kai , Yang Dawei , Bai Dongsheng , Liao Yan , Zhou Yuxin , Yu Zhou , Yu Xiaoxuan , Guo Qinglong , Lu Na 
Published: August 2018

Decreasing bone marrow (BM) microvessel density and circulating angiogenic cytokine levels are promising strategies for the treatment of relapsed and resistant acute myeloid leukemia (AML). Previous studies have reported that wogonoside could inhibit the progression of AML and suppress angiogenesis in a solid tumor, but the correlation of these two effects was ignored. In this research, we determined whether wogonoside could inhibit angiogenesis in this hematologic malignancy. We found that wogonoside could inhibit tumor growth and progression, and prolong the survival of nude mice inoculated with U937/MDR. Besides, reducing BM angiogenesis might cause therapeutic effect against resistant AML. Therefore, coculture between AML cells and BM stromal cells was established to imitate their crosstalk. Then, the effect of wogonoside on BM angiogenesis was tested in vitro and in vivo. We found that wogonoside could suppress microvessel formation in the chicken chorioallantoic membrane assay model and matrigel plug assay. The mechanism research revealed that wogonoside could block the JAK2‐STAT3 pathway in AML cells and stromal cells to break their positive feedback. We detected several cytokines related to AML or angiogenesis and found that secreted interleukin‐8 was a significant angiogenic cytokine to induce BM angiogenesis. These findings supported that new diagnostics and promising treatment strategies could be developed in relapsed and resistant AML patients.
Creative Failure: Why Can't People Solve Creative Problems
Authors: Mumford Michael D. , Martin Robert , Elliott Samantha , McIntosh Tristan 
Published: August 2018

AbstractAlthough people attempt many creative problem solutions, in general, most creative problem‐solving efforts, at least real‐world efforts, fail. In the present effort, we examine the reasons creative problem‐solving efforts typically fail. We argue that creative problem‐solving efforts fail, in part, due to the fundamental nature of the kinds of problems that call for creative thought. However, the nature of people's creative problem‐solving skills and the context in which they attempt to develop and implement creative problem solutions also results in failed attempts to solve creative problems. Based on these observations, we discuss how one might seek to develop people to encourage more success in creative problem‐solving efforts.
Ultrasound of peripheral nerves in neuralgic amyotrophy
Authors: van Rosmalen Marieke , Lieba‐Samal Doris , Pillen Sigrid , van Alfen Nens 
Published: August 2018

ABSTRACTIntroduction: Neuralgic amyotrophy (NA) can often be difficult to diagnose. Nerve ultrasound (US) is potentially useful, but it is operator‐dependent, especially for small nerves. Methods: Fifty‐one consecutive patients with NA (mean duration 16 months) and 50 control subjects underwent US of the brachial plexus and major nerves of the upper extremity at predefined sites. We compared cross‐sectional areas (CSAs) of affected and unaffected sides with controls and sides within patients. Results: The median nerve and radial nerve at the level of the upper arm were enlarged on the affected sides compared with controls and the unaffected sides of patients. Enlargement was most pronounced for affected sides vs. controls (median 44%, radial 67%). Discussion: NA patients showed increased CSAs, especially in the major nerves of the upper limb, even after longer disease duration. This could make US a useful adjunct in diagnosing NA. Muscle Nerve 59:55–59, 2019
Epithelial‐to‐mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition
Authors: McCorry Amy MB , Loughrey Maurice B , Longley Daniel B , Lawler Mark , Dunne Philip D 
Published: August 2018

AbstractThe process of epithelial‐to‐mesenchymal transition (EMT) in cancer is a well‐described process whereby epithelial tumour cells undergo molecular/phenotypic changes and transition to a mesenchymal biology. To aid in the transcriptional characterisation of this process, gene expression signatures have been developed that attribute a relative EMT score to samples in a given cohort. We demonstrate how such EMT signatures can identify epithelial cell line models with high levels of transition but also highlight that, unsurprisingly, fibroblast cell lines, which are inherently mesenchymal, have a higher EMT score relative to any epithelial cell line studied. In line with these data, we demonstrate how increased tumour stromal composition, and reduced epithelial cellularity, significantly correlates with increasing EMT signature score, which is evident using either in silico subtyping analysis (p < 0.00001) or in situ histopathological characterisation (p < 0.001). Considered together, these results reinforce the importance not only of interdisciplinary research to correctly define the nature of EMT biology but also the requirement for a cadre of multidisciplinary researchers who can analyse and interpret the underlying pathological, bioinformatic and molecular data that are essential for advancing our understanding of the malignant process. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Domperidone for insufficient lactation in England 2002‐2015: A drug utilization study with interrupted time series analysis
Authors: Mehrabadi Azar , Reynier Pauline , Platt Robert W. , Filion Kristian B. 
Published: August 2018

AbstractPurposeOur aim was to describe trends in the prescription of domperidone for insufficient lactation in England, the characteristics of women prescribed it postpartum, and the impact of a 2014 European Medicines Agency (EMA) recommendation to restrict its use due to a potential increased risk of sudden cardiac death associated with its use.MethodsWe conducted a population‐based cohort study with interrupted time series analysis using data from the Clinical Practice Research Datalink linked to Hospital Episode Statistics. We identified women with live births from 2002 to 2015, excluding those with nonlactation indications for domperidone (n = 247 349). We evaluated trends in the prescription rate of domperidone in the 6 months postpartum and differences in this rate before and after the EMA recommendation.ResultsDomperidone was prescribed among 1438 deliveries at a rate of 1.24 per 100 person‐years. This rate increased from 0.56 to 2.1 per 100 person‐years between 2002‐2004 and 2011‐2013 (rate ratio: 3.8; 95% confidence interval [CI], 3.2‐4.6). Prescribing decreased in level by 0.35 (95% CI, −0.86 to 0.16) per 100 person‐years immediately following the recommendation with little change in trend (0.003; 95% CI, −0.059 to 0.065 per 100 person‐years). Following the recommendation, prescription of doses >30 mg and coprescription of drugs with a risk of torsade de pointes decreased. No arrhythmic events were observed among domperidone users.ConclusionsAlthough we observed an important increase in prescribing during the study period, domperidone remains infrequently prescribed postpartum in England. While overall prescribing changed little, some prescribing practices became more restricted following the EMA's recommendation.
Limited genetic structure and demographic expansion of theBrassicogethes aeneuspopulations in France and in Europe
Authors: Juhel Amandine S , Barbu Corentin M , Valantin‐Morison Muriel , Gauffre Bertrand , Leblois Raphaël , Olivares Jérôme , Franck Pierre 
Published: August 2018

AbstractBackgroundThe pollen beetle,Brassicogethes aeneus(Fabricius, 1775), is one of the most significant pests of oilseed rape. To shed light on past and current pollen beetle demography (dispersal, population size), 12 microsatellite markers were developed, and population genetic diversity and structure were analysed at different spatial scales in France and in Europe from 433 individuals collected in 18 winter oilseed rape fields.ResultsGenetic differentiation among the population samples was low but was significant between the Estonian sample and the rest of Europe. Isolation by distance was significant only at the European scale. Genetic variability was similar among the 18 population samples. Demographic inferences suggested a recent expansion ofB. aeneuspopulation size over Europe, possibly corresponding to an increase in oilseed rape crop area during past decades.ConclusionCurrent population size and dispersal are not straightforward to estimate from the distribution of genetic variability inB. aeneusover Europe because of the complexity of the demographic history of this pest. Nevertheless, because gene flow was important enough to prevent strong genetic differentiation at large geographical scales, the management of pollen beetle populations should likely be thought of at a continental Europe level. © 2018 Society of Chemical Industry
Remain or return home: The migration intentions of first‐generation migrants in Italy
Authors: Bonifazi Corrado , Paparusso Angela 
Published: August 2018

AbstractInvestigating future migration intentions as a proxy of future migration behaviours is useful to capture a more complete understanding of the entire migration process. This also allows a fuller consideration of the policy implications of these intentions for the origin and destination countries. The aim of this paper is to analyse the individual factors associated with the return migration intentions of first‐generation migrants living in Italy, a new immigration country, whose migrants' return intentions have been little explored so far. We use data from the survey on the “Social Condition and Integration of Foreign Citizens” carried out by ISTAT in 2011–2012, and we apply a binary logistic regression model. The results show both the complexity and the interconnection of the factors associated with return migration intentions and that migration projects, histories, and goals count more than legal status for return intentions. Moreover, results prove that return migration intentions are influenced by conflicting processes, whose outcomes are not always easy to schematize: integration is a factor that tends to strengthen the ties with the country of residence, whereas transnationalism reinforces those with the country of origin. These factors should be considered by policymakers, especially when immigration assumes a crucial role in the receiving countries' labour market structure and population dynamics, such as in the case of Italy. Different migratory backgrounds, profiles, histories, and projects will require in‐depth examination by scientists and policymakers, because the long‐term ability and willingness of a host country to attract and retain migrants should be adapted accordingly.
Small‐Sized Bimetallic CuPd Nanoclusters Encapsulated Inside Cavity of NH2‐UiO‐66(Zr) with Superior Performance for Light‐Induced Suzuki Coupling Reaction
Authors: Sun Dengrong , Xu Mengpeng , Jiang Yongteng , Long Jinlin , Li Zhaohui 
Published: August 2018

AbstractBimetallic CuPd nanoclusters with a small size of ≈0.9 nm are encapsulated inside cavities of NH2‐UiO‐66(Zr) via double‐solvent impregnation, followed by a reduction process with NaBH4. As compared with monometallic Pd@NH2‐UiO‐66(Zr), bimetallic CuPd@NH2‐UiO‐66(Zr) shows superior performance for light‐induced Suzuki coupling reaction since the introduced Cu acts as an electron mediator to facilitate the transfer of photogenerated electrons from light‐excited NH2‐UiO‐66(Zr) to Pd, to form electron‐rich Pd. Moreover, CuPd@NH2‐UiO‐66(Zr) also shows higher activity than CuPd/NH2‐UiO‐66(Zr), in which CuPd nanoparticles are deposited on the surface of NH2‐UiO‐66(Zr). The as‐obtained CuPd@NH2‐UiO‐66(Zr) is stable and can be applied in the coupling of a variety of substituted iodobenzenes and phenylboronic acids. The simultaneous encapsulation of metallic Pd and Cu, acting as a catalytic active site and mediator respectively, inside the cavities of NH2‐UiO‐66(Zr), represents a novel strategy for designing multifunctional metal‐organic framework based catalysts for light‐induced organic reactions.
c-MPL Is a Candidate Surface Marker and Confers Self-Renewal, Quiescence, Chemotherapy Resistance, and Leukemia Initiation Potential in Leukemia Stem Cells
Authors: Li Huan , Zhao Na , Li Yihui , Xing Haiyan , Chen Shuying , Xu Yingxi , Tang Kejing , Tian Zheng , Wang Min , Rao Qing , Wang Jianxiang 
Published: August 2018

Abstract
Acute myeloid leukemia (AML) is initiated and maintained by a unique, small subset of leukemia cells known as leukemia stem cells (LSCs). Self-renewal, quiescence, and chemotherapy resistance are key stemness properties of LSCs that are essential for poor clinical responses to conventional therapies. Identifying LSC surface markers and targeting LSCs are important for the development of potential therapies. In this study, application of chemotherapy treatment in AML-ETO9a (AE9a) leukemia mice led to the enrichment of a chemotherapy-resistant cell population identified as Lin−c-Kit+c-MPL+. In addition, this c-MPL-positive cell population within Lin−c-Kit+ leukemia cells included a high percentage of cells in a quiescent state, enhanced colony formation ability, and increased homing efficiency. Serial transplantation demonstrated that Lin−c-Kit+c-MPL+ cells displayed a significantly high potential for leukemia initiation. Furthermore, it was demonstrated that in AML patients, c-MPL was expressed on the majority of CD34+ leukemia cells and that the proportion of c-MPL+ cells in CD34+ leukemia cells is associated with poor prognosis. Finally, AMM2, an inhibitor of c-MPL, was shown to significantly enhance the survival of AE9a leukemia mice when combined with chemotherapeutic agent. These results indicate that c-MPL is a candidate LSC surface marker that may serve as a therapeutic target for the elimination of LSCs.
Perspectives of Microwaves‐Enhanced Heterogeneous Catalytic Gas‐Phase Processes in Flow Systems
Authors: Stankiewicz Andrzej , Sarabi Farnaz Eghbal , Baubaid Abdul , Yan Peng , Nigar Hakan 
Published: August 2018

AbstractThe paper discusses the currents status and future perspectives of the utilization of microwaves, as a selective and locally controlled heating method, in heterogeneous catalytic flow reactors. Various factors related to the microwave‐catalyst interaction and the design of microwave‐assisted catalytic reactor systems are analyzed. The analysis clearly shows the superiority of the traveling‐wave systems over the mono‐mode and multi‐mode cavity‐based systems when it comes to the design and application of microwave flow reactors at relevant production scales.
Influence of oil aging on the motion characteristics of cellulose particles and conductivity in contaminated mineral oil and natural ester under DC electric field
Authors: Liao Ruijin , Dan Min , Hao Jian , Yang Lijun , Li Yanqing 
Published: August 2018

AbstractNatural esters are beginning to be utilized as transformer oil, so certain problems happening during their operation need to be solved urgently. To explore the effect of pollution on the insulation performance of oil, in this paper we investigate the motion characteristics of cellulose particles and conductivity in a mineral oil and a natural ester. The influence of oil aging, DC electric filed strength, and moisture content of the cellulose particles is considered. It is found hat with increasing electric field strength, aging of the oil, and moisture of the particles, the motion of cellulose particles becomes more obvious. The bridging velocity becomes higher and stable bridges grow more compact. The saturation current in the contaminated oil increases exponentially with the electric field strength. The saturation current in the contaminated natural ester is smaller than that in the contaminated mineral oil under the same electric field and particle concentration, especially when the oil is aged. For the mineral oil, the ratio of the conductivity current in contaminated oil to that in clean oil is higher under a lower electric field. However, the situation is opposite in the case of the natural ester. Fewer cellulose bridges and lower saturation current imply that the natural ester has a better insulation property and resistance to pollution. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Time to Readmission and Mortality Among Patients Undergoing Liver and Pancreatic Surgery
Authors: Chen Qinyu , Bagante Fabio , Olsen Griffin , Merath Katiuscha , Idrees Jay J. , Beal Eliza W. , Akgul Ozgur , Cloyd Jordan , Dillhoff Mary , Schmidt Carl , White Susan , Pawlik Timothy M. 
Published: August 2018

AbstractBackgroundThe impact of time to readmission (TTR) on post‐discharge mortality has not been well examined. We sought to define the impact of TTR on postoperative mortality after liver or pancreas surgery.MethodsA retrospective cohort analysis of liver and pancreas surgical patients was conducted using 2013–2015 Medicare Provider Analysis and Review database. Patients were subdivided into TTR groups: 1–5 days, 6–15, 15–30, 31–60, 61–90, and no readmission. The association of index complication, readmission causes, TTR, and mortality was assessed.ResultsAmong 18,177 patients, a total of 4485 (24.7%) patients were readmitted within 90 days of discharge. Major causes for readmission differed across TTR groups. Patients readmitted within 1–15 days were more likely to be readmitted for postoperative infection compared with patients who had a late readmission (1–5 days: 63.1% vs. 6–15 days: 65.0% vs. 61–90 days: 39.3%; P < 0.001). In contrast, causes of late readmissions were more likely related to gastrointestinal complications (1–5 days: 28.9% vs. 61–90 days: 39.7%; P < 0.001). Compared with no readmission, 180‐day mortality was highest among patients readmitted within 16–30 days (aOR 3.60; 95% CI 2.94–4.41). Among patients with index complications, patients who were readmitted within 1–5 days had a higher risk‐adjusted 180‐day mortality than late readmission (1–5 days: 37.3% vs. 61–90 days: 27.1%) (P < 0.001).ConclusionsAmong patients who were readmitted, the incidence of mortality increased with TTR up to 60 days after discharge yet decreased thereafter. The relation of TTR and mortality was particularly pronounced among those patients who had an index complication. Future efforts should consider TTR when identifying specific approaches to decrease readmission.
Are miserly budgets putting businesses at risk of cyber-attack?
Authors: Brown Tim 
Published: August 2018

If you perform a search of the term ‘ransomware’ on Google, you will see two things. The first is a definition of WannaCry, the ransomware attack that, on 12 May 2017, spread around the world and affected hundreds of targets, including public utilities, large corporations and, most notably, crippled the NHS in the UK. 1 But you'll also see a series of news stories and, regardless of what day you type ‘ransomware’ into the search bar, you're likely to see stories of attacks from just days ago, or, in some cases, just hours ago. All businesses are at risk of cyber-attacks that are all too often successful. Is this due to a lack of budget, or are budgets being spent in the wrong way? Would simply spending more money be enough to help? All businesses face budget pressures – which means they need to understand how to spend their budgets wisely. And this is where managed service providers (MSPs) can play a crucial role. Tim Brown of SolarWinds explains how MSPs can supply the skills and expertise to ensure that businesses have the right combination of technology and personnel.
7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet
Authors: Biasiotto Giorgio , Zanella Isabella , Predolini Federica , Archetti Ivonne , Cadei Moris , Monti Eugenio , Luzzani Marcello , Pacchetti Barbara , Mozzoni Paola , Andreoli Roberta , De Palma Giuseppe , Serana Federico , Smeds Annika , Di Lorenzo Diego 
Published: August 2018

Abstract7-Hydroxymatairesinol (7-HMR) is a plant lignan abundant in various concentrations in plant foods. The objective of this study was to test HMRLignan™, a purified form of 7-HMR, and the correspondingPicea abiesextract (total extractP. abies; TEP) as dietary supplements on a background of a high-fat diet (HFD)-induced metabolic syndrome in mice and in the 3T3-L1 adipogenesis model. Mice, 3 weeks old, were fed a HFD for 60 d. Subgroups were treated with 3 mg/kg body weight 7-HMR (HMRLignan™) or 10 mg/kg body weight TEP by oral administration. 7-HMR and TEP limited the increase in body weight (−11 and −13 %) and fat mass (−11 and −18 %) in the HFD-fed mice. Epididymal adipocytes were 19 and −12 % smaller and the liver was less steatotic (−62 and −65 %). Serum lipids decreased in TEP-treated mice (−11 % cholesterol, −23 % LDL and −15 % TAG) and sugar metabolism was ameliorated by both lignan preparations, as shown by a more than 70 % decrease in insulin secretion and insulin resistance. The expression of several metabolic genes was modulated by the HFD with an effect that was reversed by lignan. In 3T3-L1 cells, the 7-HMR metabolites enterolactone (ENL) and enterodiol (END) showed a 40 % inhibition of cell differentiation accompanied by the inhibited expression of the adipogenic genesPPARγ,C/EBPαandaP2. Furthermore, END and ENL caused a 10 % reduction in TAG uptake in HEPA 1–6 hepatoma cells. In conclusion, 7-HMR and TEP reduce metabolic imbalances typical of the metabolic syndrome and obesity in male mice, whereas their metabolites inhibit adipogenesis and lipid uptakein vitro.
On the General Solution of the Heideman–Hogan Family of Recurrences
Authors: Hone Andrew N. W. , Ward Chloe 
Published: August 2018

AbstractWe consider a family of nonlinear rational recurrences of odd order which was introduced by Heideman and Hogan, and recently rediscovered in the theory of Laurent phenomenon algebras (a generalization of cluster algebras). All of these recurrences have the Laurent property, implying that for a particular choice of initial data (all initial values set to 1) they generate an integer sequence. For these particular sequences, Heideman and Hogan gave a direct proof of integrality by showing that the terms of the sequence also satisfy a linear recurrence relation with constant coefficients. Here we present an analogous result for the general solution of each of these recurrences.