bluuebunny/crossref_metadata_2025_split huggingface dataset:
Het particulier beroep tot nietigverklaring en het Montessori-arrest
Authors: Barents R. 
Published: June 2019

Het particulier beroep tot nietigverklaring en het Montessori-arrest
Bij het Verdrag van Lissabon (2009) is in de vierde alinea van artikel 263 VWEU een derde zinsnede ingevoegd, op grond waarvan een particulier beroep kan instellen tegen ‘regelgevingshandelingen die geen uitvoeringsmaatregelen met zich meebrengen’. In het op 6 november 2018 gewezen arrest in de gevoegde zaken C-622/16 t/m C-624/16 P, Montessori e.a./Commissie e.a., ECLI:EU:C:2018:873 heeft het Hof van Justitie geoordeeld dat het begrip ‘regelgevingshandeling’ betrekking heeft op ‘alle niet-wetgevingshandelingen van algemene strekking’. Daaronder vallen ook besluiten van de Commissie over nationale steunregelingen. Met dit arrest is een bijna tien jaar durende zoektocht naar de strekking van dit begrip voorlopig afgesloten. In deze bijdrage worden de achtergronden en gevolgen van deze uitspraak nader toegelicht.HvJ 6 november 2018, gevoegde zaken C-622/16 t/m C-624/16 P, Montessori e.a./Commissie e.a., ECLI:EU:C:2018:873.
A Deep Learning Convolutional Neural Network Can Recognize Common Patterns of Injury in Gastric Pathology
Authors: Martin David R. , Hanson Joshua A. , Gullapalli Rama R. , Schultz Fred A. , Sethi Aisha , Clark Douglas P. 
Published: June 2019

Context.—Most deep learning (DL) studies have focused on neoplastic pathology, with the realm of inflammatory pathology remaining largely untouched.Objective.—To investigate the use of DL for nonneoplastic gastric biopsies.Design.—Gold standard diagnoses were blindly established by 2 gastrointestinal pathologists. For phase 1, 300 classic cases (100 normal, 100 Helicobacter pylori, 100 reactive gastropathy) that best displayed the desired pathology were scanned and annotated for DL analysis. A total of 70% of the cases for each group were selected for the training set, and 30% were included in the test set. The software assigned colored labels to the test biopsies, which corresponded to the area of the tissue assigned a diagnosis by the DL algorithm, termed area distribution (AD). For Phase 2, an additional 106 consecutive nonclassical gastric biopsies from our archives were tested in the same fashion.Results.—For Phase 1, receiver operating curves showed near perfect agreement with the gold standard diagnoses at an AD percentage cutoff of 50% for normal (area under the curve [AUC] = 99.7%) and H pylori (AUC = 100%), and 40% for reactive gastropathy (AUC = 99.9%). Sensitivity/specificity pairings were as follows: normal (96.7%, 86.7%), H pylori (100%, 98.3%), and reactive gastropathy (96.7%, 96.7%). For phase 2, receiver operating curves were slightly less discriminatory, with optimal AD cutoffs reduced to 40% across diagnostic groups. The AUCs were 91.9% for normal, 100% for H pylori, and 94.0% for reactive gastropathy. Sensitivity/specificity parings were as follows: normal (73.7%, 79.6%), H pylori (95.7%, 100%), reactive gastropathy (100%, 62.5%).Conclusions.—A convolutional neural network can serve as an effective screening tool/diagnostic aid for H pylori gastritis.
Análise espacial da taxa de alfabetização e sua relação com os aspectos socioeconômicos nos municípios paranaenses
Authors: Luquini Renan Henrique , Castro Gustavo Henrique Leite de , Parré José Luiz 
Published: June 2019

O presente estudo tem como objetivo analisar espacialmente a alfabetização nos municípios do estado do Paraná sob a óptica socioeconômica por meio de três variáveis: renda média, índice de Gini e grau de urbanização. Para isso, a base de dados utilizada foi malha georeferênciada do Paraná (shapefile) disponível no Instituto Paranaense de Desenvolvimento Econômico e Social – IPARDES, e dados referentes ao Censo demográfico do ano de 2010 para os municípios paranaenses. Os resultados encontrados para a região evidenciam que os valores a partir do modelo econométrico espacial (Modelo de Erro Espacial) se mostraram superiores ao MQO e mostram que quanto menor é o Índice de Gini e maior a Renda Média e a Urbanização, maior é a taxa de alfabetização nos municípios paranaenses. Observa-se a necessidade de políticas com o intuito de uma melhor distribuição de renda territorial e em uma melhora no transporte escolar ou mesmo o incentivo a escolas no campo.
Chest pain secondary to membranous subaortic stenosis in a young woman
Authors: Brodyn Nicholas E. , Haft Jacob I. 
Published: June 2019

Abstract
Left ventricular outflow obstruction can be divided into three distinct categories: valvular aortic stenosis, the most common form; supravalvular aortic stenosis, which is often seen in early childhood; and subvalvular stenosis, which can be further subdivided into muscular, tunnel, and fibromembranous subtypes. All may be found in a patient seen with symptoms of angina, syncope, or heart failure as a precursor to sudden death. Prompt clinical recognition is essential as is a high degree of suspicion when these signs are associated with a systolic ejection murmur on clinical examination. Echocardiography and a meticulous Doppler examination are very useful in the diagnosis of these disorders as well as in further distinguishing among the different subtypes. The authors describe the case of a 40-yearold woman with chest pain refractory to medical therapy and a long systolic ejection murmur.
Shame and the origin of physician-patient conflict
Authors: Martin James T. 
Published: June 2019

Abstract
Shame is a powerful negative emotion that motivates much intrapersonal and interpersonal conflict. The relationship between patient and physician can turn to conflict if the medical environment elicits shame in the patient; conflict arises when the patient externalizes the cause and blames the physician for negative feelings. Patients who suffer from hyperactive and reactive shame responses may require particularly sensitive care. Including the assessment of shame reactivity in the medical history can help identify such persons. Measures that reduce shame should improve compliance and reduce the incidence of malpractice suits.
Formulation and Utilization of Isabgol Dietetic Cookies for Boosting the Digestive Process
Authors: Tripathi Devika , Tiwari Ritesh Kumar 
Published: June 2019

Aim: The present research was carried out to characterize and utilize Isabgol, for preparation of dietetic cookies. The production of cookies enriched with Isabgol can be considered as an alternative way to include this health promoter fiber in human nutrition.
Place and Duration of Study: Isabgol, (Psyllium husk) was procured from the local market were collected from the local area of Bareilly region, India. The plant material was identified and authenticated by the Department of Pharmacognosy of Ram Murti Smarak College of Engineering & Technology (Pharmacy), Bareilly, India.
Methodology: Six different formulations of cookies were prepared using varying concentrations of Isabgol. All the preparations were according to the guidelines of AACC (2000). Physical and chemical traits diameter, thickness, moisture content, crude protein, of prepared cookies were evaluated.
Results: Straight grade flour was replaced with Isabgol in different combinations such as 5, 10, 15, 20 and 25%. Regarding the characterization of Isabgol, mean values obtained for moisture, crude protein, crude fat, the crude fiber in husk were 6.43±0.05, 2.08±0.06, 0.09±0.01, and respectively. Moreover, total dietary fiber was found to be 76.63±1.32. Physical characteristics of dietetic cookies i.e. diameter and spread ratio were diminished with the addition of Isabgol while thickness was increased. Results regarding the storage of the cookies showed an increase in diameter and spread ratio whilst thickness depicted a decreasing trend. The chemical assay revealed higher crude protein content in control cookies.
Conclusion: Softer cookies with low gross energy were obtained with the addition of Isabgol. Isabgol based cookies showed gradual enhancement in dietary fiber content as the amount of husk was increased in the formulation. The resultant cookies may have the potential to manage the digestion and bowel function in human subjects.
XRCC1 A910G Polymorphism and Gastric Cancer Risk in an Brazilian Population in the Amazon Region
Authors: Oliveira Gabriel Neto , Jr Olavo Magalhães Picanço , Rodrigues Artemis Socorro do N. 
Published: June 2019

The objective of this study was to examine the association between the XRCC1 A910G polymorphism in gastric cancer patients in the city of Macapá, State of Amapá, Amazonia, Brazil. DNA samples were obtained from 102 individuals, of which 40 were cancer patients and 62 controls. Polymerase Chain Reaction (PCR) was carried out to detect polymorphism, followed by PCR-RFLP analysis with the restriction enzyme HhaI. Of the 40 patients analysed, 22.5% had the Thr910Thr (A/A) genotype, while Ala910Ala (G/G) and Thr910Ala (A/G) genotypes accounted for 25% and 52.5% of samples, respectively. In the control group, of the 62 samples analysed, 74.1% had the Thr910Thr (A/A) genotype, while Ala910Ala (G/G) and Thr910Ala (A/G) represented 9.6% and 16.1% of samples, respectively. Our findings demonstrate that A910G polymorphism was found in most of the patients with gastric cancer in the study population. The G allele was frequently found in the analysed samples, as also observed in the genotype frequency, where AG and GG genotypes were present in cancer patients. This is the first study in Brazil to report the association between A910G polymorphism and gastric cancer.
Liquid biopsy in pancreatic ductal adenocarcinoma: current status of circulating tumor cells and circulating tumor DNA
Authors: Lee Jee‐Soo , Park Sung Sup , Lee Young Kyung , Norton Jeffrey A. , Jeffrey Stefanie S. 
Published: June 2019

Reliable biomarkers are required to evaluate and manage pancreatic ductal adenocarcinoma. Circulating tumor cells and circulating tumor DNA are shed into blood and can be relatively easily obtained from minimally invasive liquid biopsies for serial assays and characterization, thereby providing a unique potential for early diagnosis, forecasting disease prognosis, and monitoring of therapeutic response. In this review, we provide an overview of current technologies used to detect circulating tumor cells and circulating tumor DNA and describe recent advances regarding the multiple clinical applications of liquid biopsy in pancreatic ductal adenocarcinoma.
C
oprothermobacteraceae
Authors: Pavan María Elisa , Pavan Esteban E. , Kämpfer Peter , Pettinari María Julia , López Nancy I. 
Published: June 2019

Abstract

Co.pro.ther.mo.bac.te.ra.ce'ae. N.L. masc. n.
Coprothermobacter
type genus of the family; ‐
aceae
ending to denote a family; N.L. fem. pl. n.
Coprothermobacteraceae
the family of
Coprothermobacter
.

Coprothermobacterota / Coprothermobacteria / Coprothermobacterales / Coprothermobacteraceae

Rod‐shaped cells. Stains Gram‐negative. Nonmotile. No spore formation. Strictly anaerobic. Thermophilic. Chemoorganotrophs. Proteolytic fermenters that produce acetic acid, H
2
, and CO
2
as the main end products. Able to reduce thiosulfate, but not sulfate, to sulfide. Deep‐branching bacterial phylogenetic lineage based on 16S rRNA genes and phylogenomic analyses (
see
Coprothermobacterota
).
Coprothermobacteraceae
is the only family of the order
Coprothermobacterales
. The family currently accommodates a single genus,
Coprothermobacter
.

DNA G+C content (mol%)
: 42.5–44.8.

Type genus
:
Coprothermobacter
Rainey and Stackebrandt 1993, 858
VP
.
M
ethanofollis
Authors: Lai Mei‐Chin 
Published: June 2019

Abstract

Me.tha.no.fol'lis. N.L. neut. n.
methanum
methane; N.L. pref.
methano
‐, pertaining to methane; L. masc. n.
follis
, a cushion or pillow inflated with air, a bag; N.L. masc. n.
Methanofollis
, methane‐producing bag.

Euryarchaeota / Methanomicrobiales / Methanomicrobiales / Methanomicrobiaceae / Methanofollis

Cells belonging to
Methanofollis
are irregular cocci, occurring singly, 1.2–3.0 µm in diameter. Cells lyse upon the addition of 1% SDS (w/v) due to its proteinaceous S‐layer composed of hexagonally arranged glycoprotein subunits with an apparent molecular mass of 118–139 kDa. Cells stain Gram‐negative. Some strains are motile with peritrichous flagella. Strictly anaerobic methane‐producing archaeon. Substrates for growth and methane production are H
2
/CO
2
or formate. Some species may use 2‐propanol, 2‐butanol, ethanol, 1‐propanol, and 1‐butanol as electron donors in place of H
2
. Acetate is a required as carbon source for growth. Mesophilic (range 20–45°C, optimal temperature 37–40°C). The optimum pH for growth is about 7.0 (pH range 5.6–8.8). Some species may have other complex nutrient requirements, usually fulfilled by yeast extract. NaCl may be required or stimulatory for growth (Table 1). The growth of cells is usually promoted by supplementation of the medium with 1–2 μM tungstate. On the basis of the 16S rRNA gene sequence phylogeny analyses, the genus
Methanofollis
is a member of family
Methanomicrobiaceae
and order
Methanomicrobiales
.

DNA G + C content (mol%)
: 54–60 (
T
m
).

Type species
:
Methanofollis tationis
(Zabel, König and Winter 1984) Zellner, Boone, Keswani, Whitman, Woese, Hagelstein, et al. 1999, 253
VP
(
Methanogenium tationis
Zabel, König and Winter 1986, 355).
D
esulfobacca
Authors: Galushko Alexander , Kuever Jan 
Published: June 2019

Abstract

De.sul.fo.bac'ca. L. pref.
de
from; L. n.
sulfur
sulfur; N.L. pref.
desulfo
desulfuricating, used to characterize a dissimilatory sulfate‐reducing prokaryote; L. fem. n.
bacca,
bacca
berry, especially olive; N.L. fem. n.
Desulfobacca
, a sulfate‐reducing olive‐shaped bacterium.

Desulfobacterota / Desulfobaccia / Desulfobaccales / Desulfobaccaceae / Desulfobacca

Cells are oval‐to‐rod shaped, which occur singly or in pairs. Gram‐stain‐negative. Endospores are not observed. Nonmotile. Strict anaerobe with a respiratory type of metabolism. Chemoorganoheterotroph. Acetate is used as the sole electron donor and carbon source and is oxidized to CO
2
via the anaerobic C
1
pathway (carbon monoxide dehydrogenase or Wood–Ljungdahl pathway). Sulfate, sulfite, and thiosulfate are used as terminal electron acceptors and are reduced to H
2
S. The optimal pH range for growth is 7.1–7.5. The optimal temperature range for growth is between 36 and 40°C. The major menaquinone is unknown. The pattern of polar lipids and the cellular fatty acid profiles were not determined. The genus currently accommodates a single species
Desulfobacca acetoxidans
. The type strain of the genus was isolated from an anaerobic sludge reactor fed with acetate and sulfate. So far only found in freshwater habitat and soil.

DNA G + C content (mol%)
: 52.9 (genome data).

Type species
:
Desulfobacca acetoxidans
Oude Elferink, Akkermans‐van Vliet, Bogte and Stams 1999, 349
VP
.
D
esulfovermiculus
Authors: Galushko Alexander , Kuever Jan 
Published: June 2019

Abstract

De.sul.fo.ver.mi'cu.lus. L. prefix
de
; from L. n.
sulfur
, sulfur; L. masc. n.
vermiculus
, a little worm; N.L. masc. n.
Desulfovermiculus
, vermiform sulfate‐reducing bacterium.

Desulfobacterota / Desulfovibrionia / Desulfovibrionales / Desulfohalobiaceae / Desulfovermiculus

Rod‐ or oval‐shaped curved cells, 0.5–1.5 × 1.0–3.0 µm. Occur singly or in pairs. At stationary growth phase, cells elongate to 15–20 µm. Spore formation is not observed. Gram‐stain‐negative. Motility might occur depending on the species. Strict anaerobe with a respiratory type of metabolism. Chemoorganoheterotroph and chemolithoautotroph (only
Desulfovermiculus halophilus
), using short‐chain fatty acids, alcohols, and simple organic compounds as electron donors and carbon sources; these compounds are completely oxidized to CO
2
via the anaerobic C
1
pathway (carbon monoxide dehydrogenase or Wood–Ljungdahl pathway). Sulfate and thiosulfate are terminal electron acceptors and reduced to H
2
S. Fermentation of substrates has not been observed. The optimal pH range for growth is around 6.8–7.2. Mesophilic. The optimal temperature for growth is 37°C. The major menaquinone is MK‐7 (determined only for
D. halophilus
). The major cellular fatty acids were only determined for
Desulfovermiculus utahensis
and are iso‐C
15
:0
, iso‐C
17
:0
, and iso‐C
17
:1
ω9
c
. The genus currently accommodates two species. Anoxic media containing a reductant (usually sulfide) are required. Moderately halophilic. NaCl is required for growth; the optimum is between 80 and 100 g/l. MgCl
2
is necessary for the growth of
D. utahensis
. Vitamins or yeast extract are not required. Isolated from highly mineralized stratal water of an oil field and an anoxic hypersaline sediment.

DNA G + C content (mol%)
: 51.4–56.8 (
T
m
, genome, LC).

Type species
:
Desulfovermiculus halophilus
Belyakova, Rozanova, Borzenkov, Tourova, Pusheva, Lysenko and Kolganov 2007, 1371
VP
(Effective publication: Belyakova, Rozanova, Borzenkov, Tourova, Pusheva, Lysenko and Kolganov 2006, 169).
D
ethiosulfatarculus
Authors: Galushko Alexander , Kuever Jan 
Published: June 2019

Abstract

De.thi.o.sul.fat.ar'cu.lus. L. pref.
de
, from; N.L. n.
thiosulfas ‐atis
, thiosulfate; N.L. masc. n.
arculus
, a small bow; N.L. masc. n.
Dethiosulfatarculus
, a bow‐shaped thiosulfate reducer.

Desulfobacterota / Desulfarcalia / Desulfarculales / Desulfarculaceae / Dethiosulfatarculus

Vibrio‐shaped cells that occur singly, in pairs, or in larger aggregates. Spore formation is not observed. Gram‐stain‐negative. The type species is motile. Strict anaerobe with respiratory or fermentative type of metabolism. Chemolithoautotroph and chemoorganoheterotroph, using H
2
plus CO
2
, pyruvate, oxaloacetate, yeast extract, and alanine as electron donors and carbon sources; organic compounds are oxidized to acetate. For autotrophic growth, the carbon monoxide dehydrogenase pathway (Wood–Ljungdahl pathway) is used. Only thiosulfate serves as a terminal electron acceptor and is reduced to H
2
S. Sulfate and sulfite are not reduced. Fermentative growth on pyruvate, oxaloacetate, and yeast extract. Mesophilic, with an optimal temperature for growth between 30 and 37°C. Neutrophilic, with an optimal pH for growth between 6.0–7.2. Anoxic media (with sulfide as a reductant) are necessary for growth.
Dethiosulfatarculus sandiegensis
was isolated from a methanogenic, long‐chain‐paraffin degrading consortium enriched from the marine sediments of San Diego Bay, CA, USA.

DNA G + C content (mol%)
: 52.0 (genome data).

Type species
:
Dethiosulfatarculus sandiegensis
Davidova, Wawrick, Callaghan, Duncan, Marks and Suflita 2016, 1247
VP
.
H
aloimpatiens
Authors: Fang Mingxu , Zhu Xu‐Fen 
Published: June 2019

Abstract

Ha.lo.im.pa'ti.ens. Gr. n.
hals
,
halos
salt; L. adj.
impatiens
intolerant; N.L. masc. n.
Haloimpatiens
salt‐intolerant.

Firmicutes / Clostridia / Clostridiales / Clostridiaceae / Haloimpatiens

Haloimpatiens
is a genus in the family
Clostridiaceae
. The genus currently has only one validated species,
Haloimpatiens lingqiaonensis
. The cells of
H
.
lingqiaonensis
are chemoorganotrophic rods that can ferment only on complex proteinaceous compounds. This strictly anaerobic bacterium can grow in mildly thermophilic (up to 48°C) and neutral pH conditions. The cells do not require NaCl for growth. No isoprenoid quinone is detected. The main fatty acids are C
14
:0
and C
16
:0
. The major polar lipids are diphosphatidylglycerol, phosphatidylglycerol, several phospholipids, and glycolipids. Although the only species was isolated from paper mill waste water, phylogenetically related environmental sequences revealed that the potential members in the genus
Haloimpatiens
can also be found in soils and feces.

DNA G
+
C content
(
mol
%): 30.0 (HPLC).

Type species
:
Haloimpatiens lingqiaonensis
Wu, Zhang, Sun, Zhang, Han, Pan et al., 2016, 631
VP
.
H
alotalea
Authors: Ntougias Spyridon , Zervakis Georgios I. 
Published: June 2019

Abstract

Ha.lo.ta'le.a. Gr. n.
hals
,
halos
salt; L. fem. n.
talea
a staff, rod; N.L. fem. n.
Halotalea
, a rod‐shaped organism living in saline conditions.

Proteobacteria / Gammaproteobacteria / Oceanospirillales / Halomonadaceae / Halotalea

The genus
Halotalea
, classified within the family
Halomonadaceae
, order
Oceanospirillales
, and in the class
Gammaproteobacteria
, currently consists of a single species,
Halotalea alkalilenta
, isolated from alkaline alperujo, an alkaline sludge‐like olive mill waste sampled in the vicinity of Toplou Monastery, Sitia (Crete), Greece. Cells are nonsporulating Gram‐negative, motile by peritrichous flagella, rods. Colonies on agar plates are small and nonpigmented, coloring pale yellow. The organism is alkalitolerant, growing up to pH 11; extremely halotolerant, tolerating up to 2.6 M NaCl; and sugar tolerant, resisting up to 2.5 and 1.7 M
d
‐glucose and maltose, respectively. It is a mesophilic facultative anaerobe, which lacks cytochrome c oxidase activity and displays delayed fermentation ability on glucose and dulcitol. It is chemoorganotrophic, capable of degrading phenolics, which utilizes a range of amino acids, sugars, alcohols, and organic acids as sole carbon and energy sources. Ubiquinone‐9 is the only quinone detected, and C
18:1
ω7
c
, C
16:0
, C
19:0
cyclo ω8
c
, C
12:0
3‐OH, and C
16:1
ω7
c
/iso‐C
15:0
2‐OH are the major membrane fatty acids determined. Representatives have been isolated from diverse ambient and engineered environments, including wastes, marine specimens, rhizosphere, and plant material.

DNA G + C content (mol%)
: 64.3–64.6 (genome sequences).

Type species
:
Halotalea alkalilenta
Ntougias, Zervakis and Fasseas 2007, 1981
VP
.
C
oprothermobacterota
Authors: Pavan María Elisa , Pavan Esteban E. , Kämpfer Peter , Pettinari María Julia , López Nancy I. 
Published: June 2019

Abstract

Co.pro.ther.mo.bac.te.ro'ta. N.L. masc. n.
Coprothermobacter
type genus of the type order of the phylum; ‐
ota
ending to denote the phylum; N.L. neut. pl. n.
Coprothermobacterota
, the phylum of the class
Coprothermobacteria
.

Coprothermobacterota

This phylum constitutes one of the primary lines of descent in the bacterial domain, a position strongly supported by phylogenomic analysis. The phylum is currently represented by a single class, order, family, and genus. Nonmotile rods. Stains Gram‐negative. Non‐spore‐forming. Obligately anaerobic, thermophilic, and proteolytic bacteria. Chemoorganotrophs. Acetic acid, H
2
, and CO
2
are the main fermentation end products. Able to reduce thiosulfate but not sulfate to sulfide.

Type class
:
Coprothermobacteria
Pavan, Pavan, Glaeser, Etchebehere, Kämpfer, Pettinari and López 2018, 1631.
Relaxation for online frequency estimator of bias‐affected damped sinusoidal signals based on Dynamic Regressor Extension and Mixing
Authors: Vedyakov Alexey A. , Vediakova Anastasiia O. , Bobtsov Alexey A. , Pyrkin Anton A. 
Published: June 2019

SummaryThis paper considers the problem of continuous‐time online frequency estimation for a biased damped sinusoidal signal. The previous result for a sinusoidal signal with time‐varying amplitude requires a persistency of excitation condition for regressor, which is not satisfied in the considered case. To relax this condition, we propose to use Dynamic Regressor Extension and Mixing method on the first step to replace nth‐order regression with n first‐order regression models. On the second step, two simple relaxation methods are proposed to establish necessary excitation for the first‐order gradient‐based estimator. The efficiency of the proposed approach is demonstrated through the set of numerical simulations for the exponentially damped sinusoidal signal.