bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of oral health on depression: A systematic review
Authors: Karimi Parmida , Zojaji Seyedehhasti , Fard Asal Abolghasemi , Nateghi Mohammad Navid , Mansouri Zahra , Zojaji Ramin 
Published: November 2024

AbstractIntroductionAs of 2020, about 21% of adults in the United States have a diagnosable mental health disorder, excluding substance use and developmental disorders. Depression, predicted by the WHO to be the leading cause of disease burden by 2030, is linked to various systemic conditions and has been associated with poor oral health. Both behavioral factors, like poor dental hygiene and irregular visits, and biological mechanisms, such as changes in salivary immunity, contribute to this connection, which impacts overall well‐being and quality of life. This systematic review aims include: (1) Does tooth loss affect depression? (2) Does oral pain, such as that experienced during chewing and speaking, impact depression? (3) Does oral functionality, including chewing and speaking, influence depression? (4) Does overall oral health affect depression?MethodsWe conducted a systematic search of PubMed, EBSCO host, Medline, and Google Scholar databases from January 2000 to June 2024 using relevant keywords. Studies examining the impact of oral health parameters (tooth loss, oral pain, oral functionality, overall oral health) on depression were included. Articles were included if (1) full text manuscripts in English were available, (2) the study described the association of oral health and depression, and (3) the independent value was an oral related factor and the dependent value was depression. The following were excluded from our analysis: (1) any articles where oral factors were not the independent value, (2) systematic reviews, (3) case reports, and (4) duplicate studies among our databases. Thirty‐one studies met the inclusion criteria.ResultsTooth loss, oral pain, and impaired oral functionality were consistently associated with increased depressive symptoms across the included studies. Greater tooth loss was linked to higher odds of both onset and progression of depression. Oral pain exacerbated depressive symptoms, while difficulties in chewing or speaking were associated with elevated risks of depression.ConclusionThere is a bidirectional relationship between oral health and depression, highlighting the urgent need for comprehensive public health initiatives. Integrating oral health assessments into routine medical care, and developing targeted interventions are crucial steps to mitigate the impact of poor oral health on mental health outcomes.
Association of Objectively Measured Sedentary Behavior With Arterial Stiffness: Findings From the Nijmegen Exercise Study
Authors: van der Sluijs Koen M. , Bakker Esmée A. , Kerstens Thijs P. , Stens Niels A. , de Koning Iris A. , Thannhauser Jos , Malik Afrah E. F. , Reesink Koen D. , Nabeel P. M. , Raj Kiran V. , Joseph Jayaraj ,   Nijmegen Exercise Study collaboration, Eijsvogels Thijs M. H. , Thijssen Dick H. J. 
Published: November 2024

ABSTRACTSedentary behavior (SB) may affect arterial stiffness, preceding the development of cardiovascular disease. We investigated the association of objectively measured SB with arterial stiffness. We also investigated factors that affected this association. We recruited adult volunteers and measured SB with thigh‐worn accelerometery for 24 hrs/day for eight consecutive days. Central (carotid‐femoral pulse wave velocity, cfPWV, gold standard) and local carotid arterial stiffness (stiffness index Beta and pressure‐strain elasticity EP) were measured with ultrasound. Linear regression was used and adjusted for demographics, cardiometabolic factors, and moderate‐to‐vigorous physical activity (MVPA) volume. Effect modification was studied with interaction terms. Participants (N = 664, 64 (standard deviation: 11, range: 23–89) years, 397 (59.8%) male) demonstrated 9.1 (1.6) hrs/day of SB, and arterial stiffness was 8.6 (3.0) m/s for cfPWV, 6.4 (2.9) for Beta, and 87 (43) kPa for EP. SB was not associated with cfPWV (β = 0.04 95% CI (−0.11, 0.18), p = 0.60). The association of SB with local arterial stiffness was modified by systolic blood pressure (SBP) and MVPA volume. Stratified analyses revealed positive associations of SB with Beta (β = 0.29 (0.05, 0.53), p = 0.016) and EP (β = 4.83 (1.39, 8.27), p = 0.006) in participants with SBP > 134 mmHg or > 103 min/day of MVPA (β = 0.23 (0.03, 0.42), p = 0.024 and β = 3.55 (0.82, 6.29), p = 0.011, respectively). We found no association of objectively measured SB with central arterial stiffness. However, SB was positively associated with local carotid stiffness in participants with higher SBP or MVPA levels. In certain subgroups, SB may affect carotid arterial stiffening, reinforcing the relation between SB and cardiovascular disease.
Socioeconomic, Migration, and Political Upheaval Factors in Crime: Applying the Social Disorganization Theory in Turkey
Authors: Doğan Fadime İrem 
Published: November 2024

ABSTRACTThis review attempts to provide a comprehensive investigation of the complex argument that socioeconomic conditions and crime are related through political instabilities and their impact on Turkey's economy, with a specific focus on social disorganization theory. By focusing on the Turkish labor market, this study examines the interplay of socioeconomic factors impacting crime rates and changing public views. This review highlights social disorganization and crime patterns via socioeconomic factors, migration, and political upheaval. By exploring the transformation of Turkey's labor market over many decades, this study aims to provide insights into the ongoing issues of the country.
Deconstructing Solitude and Its Links to Well‐Being
Authors: Nguyen T.‐T. , Rodriguez M. 
Published: November 2024

ABSTRACTAlthough solitude is a common experience in daily life, empirical research on its effects is scarce and challenging to interpret. Here, we propose a methodological framework to study solitude and highlight its value in understanding the link between solitude and well‐being. First, we advocate for clear conceptualization and operationalizations of solitude and provide recommendations for how to achieve these objectives. Second, we tease apart various dimensions of solitude, including its duration and underlying motivational, emotional and cognitive qualities. Finally, we integrate research from various subfields of psychology (e.g., social‐personality, clinical, developmental) and summarize the nuanced and complex relationship between solitude and well‐being, which depends on the specific dimensions being studied. Taken together, we hope the proposed framework will equip the next generation of researchers with a systematic methodology for studying solitude and ultimately facilitate more productive research in this domain.
Characterisation of the Novel HLA‐DRB5*02:02:05 Allele by Sequencing‐Based Typing
Authors: Blandin Lucie , Ralazamahaleo Mamy , Cargou Marine , Lemal Richard , Rouzaire Paul 
Published: November 2024

ABSTRACTHLA‐DRB5*02:02:05 differs from HLA‐DRB5*02:02:01 by one nucleotide substitution in codon 134 in exon 3.
Longitudinal outcomes of chronically transfused adults with sickle cell disease and a history of childhood stroke
Authors: Jones Jennifer M. , Wool Julia , Crowe Elizabeth P. , Bloch Evan M. , Pecker Lydia H. , Lanzkron Sophie 
Published: November 2024

AbstractBackgroundMany children with sickle cell disease (SCD) who suffer a stroke receive chronic transfusion therapy (CTT) indefinitely; however, their adulthood neurologic outcomes have not been reported. Understanding these outcomes is critical to inform decisions regarding curative therapy in childhood.Study Design and MethodsIn this retrospective study, we described a cohort of adults with SCD and a history of childhood stroke who received care at a single center and compared their outcomes with matched subjects without childhood stroke using chi2 and Mann–Whitney U tests.ResultsOf 42 subjects with childhood stroke, all received CTT for secondary stroke prophylaxis. Five (11%) developed recurrent stroke. The rate of stroke was similar in subjects with and without childhood stroke (0.7 vs. 1.1 per 100 person·years, p = .63). Both cohorts exhibited evidence of iron overload (median ferritin 2227 vs. 1409 ng/dL, p = .10) and alloimmunization (45% vs. 45%, p = 1.0), despite receiving care in a comprehensive SCD program.DiscussionFor adults with SCD who had a childhood stroke, our results suggest CTT returns the risk of stroke to that of age‐matched stroke naïve patients with SCD.
Non‐cyclicity and polynomials in Dirichlet‐type spaces of the unit ball
Authors: Vavitsas Dimitrios , Zarvalis Konstantinos 
Published: November 2024

AbstractWe give a description of the intersection of the zero set with the unit sphere of a polynomial that is zero‐free in the unit ball of . This description leads to a necessary condition for a polynomial to be cyclic in Dirichlet‐type spaces of the unit ball.
Dry Air Humidification With Reaction Water of Proton Exchange Membrane Fuel Cell Under Dynamic Load Follow-Up
Authors: Lee Chanhee , Kim Younghyeon , Yu Sangseok 
Published: November 2024

Abstract
Water management of the proton exchange membrane fuel cell is crucial to operate the fuel cell at high performance condition with longevity. Since the electrolyte membrane is required to maintain the level of water concentration, the water vapor should be supplied to the electrolyte membrane. On the other hand, the condensed water in the catalyst layer results in performance degradation. The water concentration inside the electrolyte membrane is balanced by back diffusion and electro-osmosis that transport water molecule from electrode to electrode. The water transport phenomena of the proton exchange membrane fuel cell is evaluated to understand the relation between back diffusion of water and electro-osmosis. The system simulation model is developed under Matlab/Simulink® Environment which includes dynamic fuel cell model, air supply with humidifier, hydrogen supply model, and thermal management model. The stack temperature is controlled by thermal management system while the anode gas humidification is supported by product water of electrochemical reaction. Since the amount of exit product water is determined by the activation of back diffusion and performance of membrane humidifier, it is necessary to understand consecutive process from component to component. A dynamic simulation is conducted over various load follow-up conditions.
Catastrophic High Pressure Feedwater Heater Overpressure Event at Stuart Power Station
Authors: Michell Frank 
Published: November 2024

Abstract
On January 10, 2017, at 1:03 p.m. eastern, J.M. Stuart Power Station’s Unit 1 #A3 High Pressure Feed Water Heater experienced a catastrophic shell failure causing significant damage to the facility. The failure occurred on Unit 1 of the four (4) unit, 2,318 MW, coal fired Stuart Station which was located on the Ohio River east of Aberdeen, Ohio. There were no fatalities but unfortunately (6) people were injured. The failure caused extensive damage to equipment and structural components that completely disabled Unit 1 and resulted in damage to several systems that also serve the other three (3) units in the plant. Unit 1 never resumed commercial operation following the incident. The plant began operations in 1970 and was permanently shut down in 2018 due to economic and environmental challenges. This paper will review the details including operating data leading up to the overpressure event, root cause investigation, and recommendations to prevent a similar failure from happening again.
Baseline Evaluation of Methanogenic Potential for Mono and Co-Digested Wastewater Biosolids and Brewery Spent Yeast
Authors: Rasmeni Zelda Z. , Madyira Daniel M. , Olatunji Obafemi O. , Adedeji Paul A. , Matheri Anthony N. 
Published: November 2024

Abstract
Co-digestion of organic rich wastewater sludge and brewery spent yeast is a prospectively viable bioenergy substrate, which can enhance future green energy and boost the emerging circular economy. Multi-objective optimization of wastewater treatment plant (WWTP) cost and its environmental footprint are considered significant and vital in modern WWTP. Despite the lauded benefits of co-digestion, current techniques developed to upgrade biogas quantity and quality in the water treatment sector have focussed on mono-substrates. This development has been associated to shortage of suitable substrates and uncertainty on the impact on biogas quality and biosolid production. Therefore, this study presents an analytic evaluation of the mono substrates and co-digestion of wastewater biosolids (WWS), and brewery spent yeast (BSY) to determine their methanogenic potential as biomass for potential energy resource recovery. Here, quantification, characterisation, and waste to energy conversion through anaerobic digestion were investigated and the results obtained were appropriately reported. The test bench was firstly calibrated, and the accuracy determined. The organic samples went through a chemical process producing biogas using the biomethane potential test technique with AMPTS 11 set-up. It was observed that the optimum biomethane yield was obtained at 304,75Nml mono digestion of brewery spent yeast. It was established that the WWS and BSY offers a high prospect for future energy mix and their contribution to circular economy cannot be underestimated. Large-scale exploration of their prospects offers significant benefits in mitigating climate change through alternative energy yield obtainable from them.
Rhizosphere microbiomes are closely linked to seagrass species: a comparative study of three coastal seagrasses
Authors: Sun Hao , Liu Xuerui , Wang Tianyu , Liu Shuai , Zhang Rui , Guo Xiangrui , Yu Zhen , Zhao Ye , Shen Pingping , Zhang Yanying 
Published: November 2024

ABSTRACT

Seagrass meadows are important marine ecosystems in coastal areas, offering ecological and economic services to the mankind. However, these ecosystems are facing declines due to climate changes and human activities. Rhizosphere-associated microbiomes play critical roles in the survival and adaptation of seagrasses. While prior studies have explored the general microbial communities and their roles in seagrass meadows, there is a gap in understanding the specific rhizosphere microbiomes of different seagrass species and their interdependent relationships. Our study analyzed the microbial community composition and their metabolism in the rhizosphere of
Ruppia sinensis
(RS),
Zostera japonica
(ZJ), and
Zostera marina
(ZM) obtained from the coastal area of Shandong, China, using high throughput and metagenome sequencing. We found that Rhodobacteraceae, Desulfocapsaceae, and Sulfurovaceae were enriched in RS, ZJ, and ZM samples, respectively, compared with the other two seagrass species, and the bacterial connections were decreased from RS to ZM and ZJ samples. The abundances of
nirKS
and
norBC
, mediating denitrification, were higher in RS samples with 2.38% ± 0.59% and 2.14% ± 0.24%, respectively. RS samples also showed a higher level of genes in assimilatory sulfate reduction but lower levels in dissimilatory sulfate reduction and oxidation, with a greater ability to convert sulfide into L-cysteine and acetate. Metagenome-assembled genomes from metagenome of RS rhizosphere had a higher diversity and were assigned to eight phyla. Our study could provide a typical project to analyze the bacterial community structures and metabolic functions in the rhizosphere microbiomes of different seagrasses.

IMPORTANCE

Seagrasses are indispensable in marine ecosystems, offering numerous critical services, with their health significantly influenced by associated rhizosphere microbiomes. Although studies have investigated the microbial communities and their ecological roles in seagrass meadows, the correlations between rhizosphere microbiome and seagrass species from a particular geographic region are limited. Some studies concentrated on the bacterial composition within the rhizosphere of various seagrasses, but the functional aspects of these microbiomes remain unexplored. Our research delves into this void, revealing that
Ruppia sinensis
,
Zostera japonica
, and
Zostera marina
host diverse bacterial community in the composition, connections, functions, and metabolism, such as nitrogen and sulfur metabolism. Our study revealed that seagrass species play an important role in shaping the rhizosphere microbiomes in an equivalent environment, emphasizing the importance of seagrass species in shaping the rhizosphere microbial communities.
Evaluation of Fungitell (1,3)-β-D-glucan assay in tear samples for rapid diagnosis of fungal keratitis
Authors: Tawde Yamini , Das Sourav , Singh Shreya , Basak Soham , Sharma Savitri , Gupta Amit , Rudramurthy Shivaprakash M. , Yadav Geetika , Ghosh Anup 
Published: November 2024

ABSTRACT

Fungal keratitis (FK) is a serious suppurative and ulcerative corneal infection leading to blindness and vision loss. Rapid diagnosis of FK can contribute to prompt clinical management with early recovery. The study aimed to standardize the detection of (1,3)-β-D-glucan (BDG) and establish the diagnostic cut-off concentration in tears of suspected FK patients along with non-infected controls. This prospective multicentric study was conducted between the period of August 2022 and April 2024. Samples were collected from three tertiary eye-care facilities across India. All suspected FK patients were enrolled in the study. Prior to tear collection, the eye and eyelid were gently cleansed using sterile normal saline (NS) and lint-free tissue paper. Subsequently, 50 µL of sterile NS was instilled into the eye, followed by tear sample collection after 60 s using sterile fine microtips. Tear samples were collected from the contralateral eyes of the FK patients, and those from healthy volunteers served as controls. The concentration of BDG in tears in varying dilutions was quantitatively measured using the Fungitell Assay Kit (Associates of Cape Cod, East Falmouth, Massachusetts). A total of 53 tear samples were analyzed at 1:10 and 1:20 dilutions. The receiver operating curve revealed an area under the curve (AUC) of 0.919 for the 1:10 dilution, with a cut-off value of 123 pg/mL, yielding a sensitivity of 100% and specificity of 84.85%. The corresponding Youden Index was 0.798. At the 1:20 dilution, the AUC was 0.898 with a cut-off of 84 pg/mL, achieving a sensitivity of 70% and specificity of 96.88% with a Youden Index of 0.670. Given the higher specificity at the 1:20 dilution, it was further validated in 145 tear samples. The validation cohort demonstrated a sensitivity of 95.56%, specificity of 83%, positive predictive value (PPV) of 71.67%, negative predictive value (NPV) of 97.65%, and diagnostic odds ratio of 112.4. Notably, a significantly higher BDG concentration (
P
< 0.0001) was observed in infected tear samples compared to controls (270.6 ± 128.5 vs 37.31 ± 31.32). Detection of BDG in tear samples is a new, non-invasive, and rapid technique showing excellent performance and can be effectively implemented for diagnosing FK in laboratories.
A modular activity to support knowledge retention, application, and metacognition in undergraduate immunology
Authors: D'Ambrosio Lisa M. 
Published: November 2024

ABSTRACT

Learning in undergraduate immunology requires students to be able to retain knowledge, to apply information to new contexts, and to self-assess their understanding of concepts. These core competencies strengthen students’ critical thinking and metacognitive skills which, in turn, enhances their ability to identify knowledge gaps and strategies to support future learning. Retrieval practice and feedback-driven metacognition are evidence-based teaching strategies that have been demonstrated to enhance knowledge retention and metacognition in a range of academic disciplines and levels of education, although their implementation and impact on learning in undergraduate immunology remain largely unexplored. To this end, I designed a modular “practice session” activity for a 12-week, upper-level, undergraduate immunology course that incorporates periodic retrieval practice and feedback-driven metacognition to support students’ knowledge retention, application of information, and metacognitive skills. Near the end of the course, a survey was conducted to assess student perceptions on whether the activity supported learning and metacognition in immunology. Instructional resources are provided to facilitate easy adaptation of this modular activity to courses of diverse science disciplines and levels of study in higher education.
Pneumococcal extracellular vesicles mediate horizontal gene transfer via the transformation machinery
Authors: Werner Lass Sarah , Smith Bailey E. , Camphire Shaw , Eutsey Rory A. , Prentice Jojo A. , Yerneni Saigopalakrishna S. , Arun Ashni , Bridges Andrew A. , Rosch Jason W. , Conway James F. , Campbell Phil , Hiller N. Luisa 
Published: November 2024

ABSTRACT

Bacterial cells secrete extracellular vesicles (EVs), the function of which is a matter of intense investigation. Here, we show that the EVs secreted by the human pathogen
Streptococcus pneumoniae
(pneumococcus) are associated with bacterial DNA on their surface and can deliver this DNA to the transformation machinery of competent cells. These findings suggest that EVs contribute to gene transfer in Gram-positive bacteria and, in doing so, may promote the spread of drug resistance genes in the population.

IMPORTANCE
This work extends our understanding of horizontal gene transfer and the roles of extracellular vesicles in pneumococcus. This bacterium serves as the model for transformation, a process by which bacteria can take up naked DNA from the environment. Here, we show that extracellular vesicles secreted by the pneumococcus have DNA on their surface and that this DNA can be imported by the transformation machinery, facilitating gene transfer. Understanding EV-mediated gene transfer may provide new avenues to manage the spread of antibiotic drug resistance.