bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of Delphi procedure consensus criteria for defining fetal growth restriction
Authors: Molina L. C. G. , Odibo L. , Zientara S. , Običan S. G. , Rodriguez A. , Stout M. , Odibo A. O. 
Published: September 2019

ABSTRACTObjectiveRecently, a Delphi procedure was used to establish new criteria for defining fetal growth restriction (FGR). These criteria require clinical validation. We sought to validate the Delphi consensus criteria by comparing their performance with that of our current definition (estimated fetal weight (EFW) < 10th percentile) in predicting adverse neonatal outcome (ANO).MethodsThis was a secondary analysis of data from a prospective cohort study of women referred for fetal growth assessment between 26 and 36 weeks' gestation. The current standard definition of FGR used in our clinical practice is EFW < 10th percentile using Hadlock's fetal growth standard. The Delphi consensus criteria for FGR include either a very small fetus (abdominal circumference (AC) or EFW < 3rd percentile) or a small fetus (AC or EFW < 10th percentile) with additional abnormal Doppler findings or a decrease in AC or EFW by two quartiles or more. The primary outcome was the prediction of a composite of ANO including one or more of: admission to the neonatal intensive care unit, cord pH < 7.1, 5‐min Apgar score < 7, respiratory distress syndrome, intraventricular hemorrhage, neonatal seizures or neonatal death. The discriminatory capacities of the two definitions of FGR for composite ANO and delivery of a small‐for‐gestational‐age (SGA) neonate, defined as birth weight < 10th percentile, were compared using area under the receiver‐operating‐characteristics curve (AUC). The sensitivity, specificity and predictive values of the methods were also compared.ResultsOf 1055 pregnancies included in the study, composite ANO occurred in 139 (13.2%). There were only two cases of early FGR (before 32 weeks); therefore, the study focused on late FGR. Our current FGR diagnostic criterion of EFW < 10th percentile was not associated significantly with composite ANO (relative risk (RR), 1.1 (95% CI, 0.6–1.8)), while the Delphi FGR criteria were (RR, 2.0 (95% CI, 1.2–3.3)). Our current definition of FGR showed higher discriminatory ability in the prediction of a SGA neonate (AUC, 0.69 (95% CI, 0.65–0.73)) than did the Delphi definition (AUC, 0.64 (95% CI, 0.60–0.67)) (P = 0.001). The AUCs of both definitions were poor for the prediction of composite ANO, despite slightly improved performance using the Delphi consensus definition of FGR (AUC, 0.53 (95% CI, 0.50–0.55)) compared with that of our current definition (AUC, 0.50 (95% CI, 0.48–0.53)) (P = 0.02).ConclusionThe newly postulated criteria for defining FGR based on a Delphi procedure detects fewer cases of neonatal SGA than does our current definition of EFW < 10th percentile, but is associated with a slight improvement in predicting
ANO. Copyright © 2020 ISUOG. Published by John Wiley & Sons Ltd.
Predictions for energy correlators probing substructure of groomed heavy quark jets
Authors: Lee Christopher , Shrivastava Prashant , Vaidya Varun 
Published: September 2019

AbstractWe develop an effective field theory (EFT) framework to perform an analytic calculation for energy correlator observables computed on groomed heavy-quark jets. A soft-drop grooming algorithm is applied to a jet initiated by a massive quark to minimize soft contamination effects such as pile-up and multi-parton interactions. We specifically consider the two-particle energy correlator as an initial application of this EFT framework to compute heavy quark jet substructure. We find that there are different regimes for the event shapes, depending on the size of the measured correlator observable, that require the use of different EFT formulations, in which the quark mass and grooming parameters may be relevant or not. We use the EFT to resum large logarithms in the energy correlator observable in terms of the momentum of a reconstructed heavy hadron to NLL′ accuracy and subsequently match it to a full QCD$$ \mathcal{O} $$O(αs) cross section, which we also compute. We compare our predictions to simulations in Pythia fore+e−collisions. We find a good agreement with partonic simulations, as well as hadronic ones with an appropriate shape function used to describe nonperturbative effects and the heavy quark hadron decay turned off. We also predict the scaling behavior for the leading nonperturbative power correction due to hadronization. Consequently, we can give a prediction for the energy correlator distribution at the level of the reconstructed heavy hadron. This work provides a general framework for the analysis of heavy quark jet substructure observables.
Yang–Mills Measure on the Two-Dimensional Torus as a Random Distribution
Authors: Chevyrev Ilya 
Published: September 2019

AbstractWe introduce a space of distributional 1-forms$$\Omega ^1_\alpha $$Ωα1on the torus$$\mathbf {T}^2$$T2for which holonomies along axis paths are well-defined and induce Hölder continuous functions on line segments. We show that there exists an$$\Omega ^1_\alpha $$Ωα1-valued random variableAfor which Wilson loop observables of axis paths coincide in law with the corresponding observables under the Yang–Mills measure in the sense of Lévy (Mem Am Math Soc 166(790), 2003). It holds furthermore that$$\Omega ^1_\alpha $$Ωα1embeds into the Hölder–Besov space$$\mathcal {C}^{\alpha -1}$$Cα-1for all$$\alpha \in (0,1)$$α∈(0,1), so thatAhas the correct small scale regularity expected from perturbation theory. Our method is based on a Landau-type gauge applied to lattice approximations.
The prognosis of stage IA synchronous endometrial endometrioid and ovarian carcinomas
Authors: Zhan Xiangbo , Li Lei , Wu Ming , Lang Jinghe 
Published: September 2019

Abstract

Introduction
Little is known about the prevalence and prognosis of synchronous endometrial and ovarian carcinomas. This report explores the survival outcomes of synchronous stage IA endometrioid endometrial and stage IA ovarian carcinomas in a retrospective cohort study.

Methods
All cases of pathological confirmed synchronous stage IA endometrial endometrioid and ovarian carcinomas from June 1, 2010, to June 1, 2017, in a teaching hospital were reviewed. Patients were followed up to February 1, 2019. Survival outcomes were compared between patients with and without synchronous carcinomas.

Results
In total, 841 cases with confirmed FIGO stage IA endometrioid endometrial carcinomas were included in the study; 33 patients (3.9%) had synchronous stage IA ovarian carcinomas, including 27 (81.8%) and 6 (18.2%) cases of endometrioid and mixed endometrioid/clear cell subtypes, respectively. After a median follow-up time of 56.8 months, 829 patients (97.9%) had definitive survival outcomes. Synchronous ovarian carcinomas had no impact on disease-free, overall or cancer-specific overall survival in univariate and multivariate analyses.

Conclusion
In these patients with stage IA endometrioid endometrial carcinoma, the genuine incidence of synchronous stage IA ovarian carcinoma was very low, and synchronous carcinoma had no significant effects on survival outcomes.
Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification
Authors:   on behalf of the Association for European Cardiovascular Pathology (AECVP), Michaud Katarzyna , Basso Cristina , d’Amati Giulia , Giordano Carla , Kholová Ivana , Preston Stephen D. , Rizzo Stefania , Sabatasso Sara , Sheppard Mary N. , Vink Aryan , van der Wal Allard C. 
Published: September 2019

Abstract
Ischemic heart disease is one of the leading causes of morbidity and death worldwide. Consequently, myocardial infarctions are often encountered in clinical and forensic autopsies, and diagnosis can be challenging, especially in the absence of an acute coronary occlusion. Precise histopathological identification and timing of myocardial infarction in humans often remains uncertain while it can be of crucial importance, especially in a forensic setting when third person involvement or medical responsibilities are in question. A proper post-mortem diagnosis requires not only up-to-date knowledge of the ischemic coronary and myocardial pathology, but also a correct interpretation of such findings in relation to the clinical scenario of the deceased. For these reasons, it is important for pathologists to be familiar with the different clinically defined types of myocardial infarction and to discriminate myocardial infarction from other forms of myocardial injury. This article reviews present knowledge and post-mortem diagnostic methods, including post-mortem imaging, to reveal the different types of myocardial injury and the clinical-pathological correlations with currently defined types of myocardial infarction.
Effects of 1-year anti-TNF-α therapies on bone mineral density and bone biomarkers in rheumatoid arthritis and ankylosing spondylitis
Authors: Gulyás Katalin , Horváth Ágnes , Végh Edit , Pusztai Anita , Szentpétery Ágnes , Pethö Zsófia , Váncsa Andrea , Bodnár Nóra , Csomor Péter , Hamar Attila , Bodoki Levente , Bhattoa Harjit Pal , Juhász Balázs , Nagy Zoltán , Hodosi Katalin , Karosi Tamás , FitzGerald Oliver , Szücs Gabriella , Szekanecz Zoltán , Szamosi Szilvia , Szántó Sándor 
Published: September 2019

Abstract

Objectives
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have been associated with generalized and localized bone loss. We conducted a comprehensive study using imaging (dual-energy X-ray absorptiometry, DXA) and laboratory biomarkers in order to determine bone health and to study the effects of anti-tumor necrosis factor (TNF) biologics in RA and AS.

Patients and methods
Thirty-six RA and 17 AS patients undergoing 1-year etanercept (ETN) or certolizumab-pegol (CZP) therapy were studied. Bone density was assessed by DXA at baseline and after 12 months. Serum C-reactive protein (CRP), calcium, phosphate, parathyroid hormone (PTH), vitamin D3, osteocalcin, procollagen type I N-propeptide (P1NP), C-terminal telopeptide (βCTX), osteoprotegerin, sclerostin (SOST), Dickkopf-1 (DKK-1), soluble receptor activator nuclear kappa B ligand (sRANKL), and cathepsin K (cathK) levels were determined at baseline and after 6 and 12 months.

Results
TNF-α inhibition was clinically effective. Anti-TNF-α halted further bone loss over 1 year. In general, anti-TNF therapy significantly increased P1NP, SOST levels, and the P1NP/βCTX ratios, while decreased DKK-1 and CathK production at different time points in most patient subsets. In the full cohort and in RA, baseline and/or 12-month bone mineral density (BMD) at multiple sites exerted inverse relationships with CRP and βCTX, and positive correlation with SOST. In AS, L2-4 BMD after 1-year biologic therapy inversely correlated with baseline βCTX, while femoral neck BMD rather showed inverse correlations with CRP.

Conclusions
Anti-TNF therapy slowed down generalized bone loss, in association with clinical improvements, in both diseases. TNF blockade may enhance bone formation and suppress joint destruction. Anti-TNF therapy may act inversely on DKK-1 and SOST. Independent predictors of BMD were SOST and βCTX in RA, whilst CRP in AS.Key Points• One-year anti-TNF therapy halted generalized bone loss in association with clinical improvement in arthritides.• Anti-TNF therapy may inversely act on DKK-1 and SOST.• Independent predictors of BMD were SOST and βCTX in RA, while CRP in AS.
Analysis on the Meiosis-Related Gene (Dmc1, Ph1) Expression in Autotriploid Carassius auratus
Authors: Qin Qinbo , Zhou Yuwei , Wang Chongqing , Zhang Minghe , Qin Huan , Zhao Chun , Liu Shaojun 
Published: September 2019

AbstractTriploid is usually considered to be unable to perform normal meiosis due to the abnormal behavior of the three sets of chromosomes. But autotriploid Carassius auratus in the Dongting water system (3n = 150, abbreviated as 3nCC) can perform normal meiosis. In artificial autotriploid Carassius auratus (3n = 150, abbreviated as 3nRR), female individuals undergo normal meiosis and produce mature gametes, while male individuals cannot. To better understand the effects of triploidization on meiosis in fish, we study the structure, methylation level, and expression level of meiosis-related genes (Dmc1, Ph1) in diploid Carassius auratus (2n = 100, abbreviated as 2nCC), Carassius auratus red var.(2n = 100, abbreviated as RCC), 3nCC and 3nRR. The results show that, compared with their diploid ancestors (2nCC and RCC), Dmc1 and Ph1 genes are hypomethylated in all 3nCC and female 3nRR, while are hypermethylated in male 3nRR. Correspondingly, Dmc1 and Ph1 genes are highly expressed in all 3nCC and female 3nRR, while are lowly expressed in male 3nRR. These results indicate that high expression of meiosis-related genes can contribute to restoration of bivalent pairing during meiosis in autotriploid Carassius auratus. This study provides new insights into the effect of DNA methylation on the fertility in triploid fish.
Primary and secondary breast angiosarcoma: single center report and a meta-analysis
Authors: Abdou Yara , Elkhanany Ahmed , Attwood Kristopher , Ji Wenyan , Takabe Kazuaki , Opyrchal Mateusz 
Published: September 2019

Abstract

Background
Primary and secondary breast angiosarcoma is a rare and aggressive malignancy with limited published literature. Optimal management is mostly based on expert opinion. Our study aims to describe a single institution experience with breast angiosarcoma and evaluate other publications on this topic to further clarify prognostic outcomes and treatment modalities in this disease.

Methods
Twenty two cases of breast angiosarcoma from Roswell Park Comprehensive Cancer Center were retrospectively analyzed. Additionally, a systemic review and meta-analysis was conducted to study the association between survival outcomes, overall survival (OS), and recurrence-free survival (RFS) in both primary (PAS) and secondary breast angiosarcoma (SAS).

Results
9 PAS patients (41%) and 13 SAS patients (59%) were retrospectively analyzed. No significant differences were noted in tumor characteristics and survival outcomes between PAS and SAS. Treatment modality had no significant effects on survival outcomes although adjuvant chemotherapy demonstrated a trend towards improved RFS in high grade tumors. 380 PAS and 595 SAS patients were included in the outcome meta-analysis. Survival outcomes were significantly worse with high grade tumors and tumor size of > 5 cm. Adjuvant radiation therapy demonstrated significantly better RFS, while adjuvant chemotherapy had no effect on survival outcomes.

Conclusion
Tumor size and grade seem to be reliable predictors of survival in both PAS and SAS. Mastectomy does not seem to be adding any additional benefit to BCS. Adjuvant radiation therapy showed statistically significant RFS benefit, while adjuvant chemotherapy can be beneficial in high grade tumors.
Simple Hybrids Based on Mo or W Oxides and Diamines: Structure Determination and Catalytic Properties
Authors: Bożek Barbara , Neves Patrícia , Oszajca Marcin , Valente Anabela A. , Połtowicz Jan , Pamin Katarzyna , Łasocha Wiesław 
Published: September 2019

Abstract
Crystalline hybrid catalysts based on molybdenum or tungsten oxide and aliphatic diamines were synthesized via simple, eco-friendly reproducible methodologies, starting from commercially available and relatively inexpensive organic and inorganic precursors, and using water as solvent under mild conditions. The crystal structures of the obtained fine powdered solids were solved ab initio from powder X-ray diffraction data. The type of organic component (1,2-diaminoethane, 1,2-diaminopropane, 1,3-diaminopropane) may play a structure-directing role. On the other hand, different metals (M = Mo, W) may lead to isostructural one-dimensional hybrids of the type MO3(L) with the same bidentate diamine ligand L. The prepared catalysts were investigated for the liquid phase oxidation of saturated and unsaturated hydrocarbons (cis-cyclooctene, cyclooctane), using different types of oxidants (O2, H2O2, tert-butyl hydroperoxide). Differences in catalytic performances associated with distinct structural features were investigated.

Graphic Abstract
Assessing wood pulp reactivity through its rheological behavior under dissolution
Authors: Ceccherini Sara , Maloney Thad 
Published: September 2019

Abstract
Recent years have witnessed an increasing interest in man-made cellulosic fibers, whose production generally requires cellulose dissolution and regeneration. Cellulosic fibers are difficult to dissolve. Thus, the recalcitrance of wood pulp can be an estimate of its reactivity. Pulp reactivity is usually assessed via complex and time-consuming laboratory simulations of the viscose process. This study proposes a faster and more convenient approach. The dissolution-based torque reactivity (DTR) test measures the evolution of the rheological properties of a pulp suspension under dissolution in cupriethylenediamine. Reactivity is quantified in terms of initial dissolution rates (IDR) and dissolution times (DT). This study describes the measurement protocol for the DTR test and its application to some commercial pulps and a series of pulps hornified to different extents. The IDR and DT values were compared with other pulp features, including degree of polymerization, molecular weight distribution, specific surface area and water retention value. The DTR test proved to be reasonably precise and fast to carry out.

Graphic abstract
Factors Associated with Patient Satisfaction of Community Mental Health Services: A Multilevel Approach
Authors: Stamboglis Niccolò , Jacobs Rowena 
Published: September 2019

Abstract
Community care is increasingly the mainstay of mental healthcare provision in many countries and patient satisfaction is an important barometer of quality of patient care. This paper explores the key factors associated with patient satisfaction with community mental health services in England and then compares providers’ performance on patient satisfaction. Our analysis is based on patient-level responses from the community mental health survey, which is run annually by the Care Quality Commission (CQC) for the years 2010 to 2013. We perform a repeated cross-section analysis, identifying factors associated with patient satisfaction via a multi-level ordered probit model, including both patient- and provider-level variables. We identify hospital-specific effects via empirical Bayes estimation. Our analysis identifies a number of novel results. First, patient characteristics such as older age, being employed, and being able to work, are associated with higher satisfaction, while being female is associated with lower satisfaction. Service contact length, time since last visit, condition severity and admission to a mental health institution, are all associated with lower satisfaction. Second, treatment type affects satisfaction, with patients receiving talking therapies or being prescribed medications being more satisfied. Third, care continuity and involvement, as proxied by having a care plan, is associated with higher satisfaction. Fourth, seeing a health professional closer to the community improves satisfaction, with patients seeing a community-psychiatric nurse, a social worker or a mental-health support worker being more satisfied. Finally, our study identifies the need for service integration, with patients experiencing financial, accommodation, or physical health needs being less satisfied. At a provider level, we find a negative association between the percentage of occupied beds and satisfaction. We further identify significant provider-specific effects after accounting for observable differences in patient and provider characteristics which suggests significant differences in provider quality of care.
Investigating Preschool Educators’ Implementation of Computer Programming in Their Teaching Practice
Authors: Otterborn Anna , Schönborn Konrad J. , Hultén Magnus 
Published: September 2019

Abstract
Modern preschool education is seen as an essential foundation for nurturing children’s digital literacy. Early childhood education environments have witnessed increased emphasis on integrating programming activities in combination with digital tablets. However, little is known about how preschool teachers implement programming as part of pedagogical strategies during practice. In Sweden, although there is a mandate to develop children’s understanding of the digital world, programming is not formally mentioned in the revised preschool curriculum. This study systematically investigates how Swedish preschool teachers implement programming activities in their teaching practice. Data was collected through a national online survey (n = 199). Findings revealed a range of apps and resources used in combination with tablets, where activity integration takes place as unplugged programming, digital programming, or as a combination of the former. Teachers markedly attributed intended learning goals around programming to tenets of computational thinking and “twenty-first century skills”. Moreover, programming was often actively linked to learning in other domains such as science, technology, mathematics, and language, approaches that show traditional Swedish preschool teaching practices being recontextualized in terms of programming. Based on the reported findings that provide insight into the implementation of programming in preschools, a logical future research avenue lies in exploring the documented programming activities from the perspective of the children.
Affordability and Non-Perfectionism in Moral Action
Authors: Rumbold Benedict , Charlton Victoria , Rid Annette , Mitchell Polly , Wilson James , Littlejohns Peter , Max Catherine , Weale Albert 
Published: September 2019

AbstractOne rationale policy-makers sometimes give for declining to fund a service or intervention is on the grounds that it would be ‘unaffordable’, which is to say, that the total cost of providing the service or intervention for all eligible recipients would exceed the budget limit. But does the mere fact that a service or intervention is unaffordable present a reasonnotto fund it? Thus far, the philosophical literature has remained largely silent on this issue. However, in this article, we consider this kind of thinking in depth. Albeit with certain important caveats, we argue that the use of affordability criteria in matters of public financing commits what Parfit might have called a ‘mistake in moral mathematics’. First, it fails to abide by what we term a principle of ‘non-perfectionism’ in moral action: the mere fact that it is practically impossible for you to do all the good that you have reason to do does not present a reason not to do whatever good you can do. And second, when used as a means of arbitratingbetweenwhich services to fund, affordability criteria can lead to a kind of ‘numerical discrimination’. Various attendant issues around fairness and lotteries are also discussed.
The Relation Between Autistic Traits, the Degree of Synaesthesia, and Local/Global Visual Perception
Authors: Burghoorn Floor , Dingemanse Mark , van Lier Rob , van Leeuwen Tessa M. 
Published: September 2019

Abstract
Synaesthesia is highly prevalent in autism spectrum disorder. We assessed the relation between the degree of autistic traits (Autism Spectrum Quotient, AQ) and the degree of synaesthesia in a neurotypical population, and hypothesized both are related to a local bias in visual perception. A positive correlation between total AQ scores and the degree of synaesthesia was found, extending previous studies in clinical populations. Consistent with our hypothesis, AQ-attention to detail scores were related to increased performance on an Embedded Figures Task and reduced susceptibility to visual illusions. We found no relation between autistic traits and performance on a motion coherence task, and no relation between synaesthesia and local visual perception. Possibly, this relation is reserved for supra-threshold synaesthetes.