bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noise Exposure May Diminish the Musician Advantage for Perceiving Speech in Noise
Authors: Skoe Erika , Camera Sarah , Tufts Jennifer 
Published: October 2018

Objective:
Although numerous studies have shown that musicians have better speech perception in noise (SPIN) compared to nonmusicians, other studies have not replicated the “musician advantage for SPIN.” One factor that has not been adequately addressed in previous studies is how musicians’ SPIN is affected by routine exposure to high levels of sound. We hypothesized that such exposure diminishes the musician advantage for SPIN.

Design:
Environmental sound levels were measured continuously for 1 week via body-worn noise dosimeters in 56 college students with diverse musical backgrounds and clinically normal pure-tone audiometric averages. SPIN was measured using the Quick Speech in Noise Test (QuickSIN). Multiple linear regression modeling was used to examine how music practice (years of playing a musical instrument) and routine noise exposure predict QuickSIN scores.

Results:
Noise exposure and music practice were both significant predictors of QuickSIN, but they had opposing influences, with more years of music practice predicting better QuickSIN scores and greater routine noise exposure predicting worse QuickSIN scores. Moreover, mediation analysis suggests that noise exposure suppresses the relationship between music practice and QuickSIN scores.

Conclusions:
Our findings suggest a beneficial relationship between music practice and SPIN that is suppressed by noise exposure.
Social Risk and Mortality
Authors: Checa Caterina , Abellana Rosa , Verdú-Rotellar Jose-Maria , Berenguera Anna , Domingo Mar , Calero Esther , Muñoz Pérez Miguel-Angel 
Published: October 2018

Background
Heart failure (HF) is a chronic condition that usually leads to death a few years after diagnosis. Although several clinical factors have been found to be related to increased mortality, less is known about the impact of social context, especially at the end stage of the disease. Knowing about social context is important to properly classify risk and provide holistic management for patients with advanced HF.

Objective
The aim of this study was to determine the impact of social context on mortality in patients with advanced HF.

Methods
A retrospective cohort study was conducted using data from clinical records on community-dwelling patients with HF and with New York Heart Association IV functional class living in Catalonia in northeastern Spain. Clinical data, patient dependency for basic activities of daily living, and social assessments were collected between 2010 and 2013. The primary outcome was all-cause mortality.

Results
Data from 1148 New York Heart Association class IV patients were analyzed. Mean (SD) age was 82 (9.0) years, and 61.7% were women. The mean (SD) follow-up was 18.2 (11.9) months. Mortality occurred in 592 patients. Social risk was identified in 63.6% of the patients, and 9.3% acknowledged having social problems. In the adjusted multivariate model, being male (hazard ratio (HR), 1.82; 95% confidence interval [CI], 1.16–2.83), having high dependency on others for basic activities of daily living (HR, 2.16; 95% CI, 1.21–3.85), and presenting with a social problem (HR, 2.46; 95% CI, 1.22–4.97) were related to an increased risk of mortality.

Conclusions
An unfavorable social profile is an independent risk factor for mortality in patients with advanced HF.
Association Between Medication Adherence and Admission Blood Pressure Among Patients With Ischemic Stroke
Authors: Chen Min-Jie , Wu Chan-Chan , Wan Li-Hong , Zou Guan-Yang , Neidlinger Susan Holli 
Published: October 2018

Background:
Poor medication adherence is one of the most important factors underlying uncontrolled blood pressure, and ensuing hypertension is the leading risk factor for stroke. However, the influence of prestroke medication nonadherence on the admission blood pressure of patients with hypertension who have had an ischemic stroke remains unclear.

Objective:
The aims of this study were to explore the influence of medication nonadherence on the admission blood pressure of patients with hypertension who have had an ischemic stroke and to analyze the reasons for medication nonadherence preceding stroke.

Methods:
A sample population of 301 patients with hypertension who have had an ischemic stroke was recruited. A questionnaire was used to investigate sociodemographic data and reasons for nonadherence. The 4-item Medication Adherence Scale was used to investigate prestroke medication adherence. Blood pressure was measured upon patient admission. Logistic regression analysis was used to identify factors influencing adherence.

Results:
In this cohort, 80.73% of the patients exhibited uncontrolled blood pressure on admission, and 26.58% had undiagnosed hypertension. Of the patients aware of their diagnosis, 75.11% were nonadherent and 10.40% had never used antihypertensive medicines. Uncontrolled admission blood pressure was positively influenced by medication nonadherence. The main causes of nonadherence included forgetfulness (58.08%), lack of belief in the need for long-term antihypertensive treatment (27.27%), and no awareness of the importance of long-term medication (24.75%).

Conclusions:
Stroke education in China should focus on patients' poor understanding of the importance for sustained antihypertensive medication adherence to improve blood pressure control and prevent stroke.
Preoperative Assessment of Cervical Vestibular Evoked Myogenic Potentials (cVEMPs) Help in Predicting Hearing Preservation After Removal of Vestibular Schwannomas Through a Middle Fossa Craniotomy
Authors: Hochet Baptiste , Achard Sophie , Lorenz Mark Brandt , Baroncini Marc , Berama Amine , Gabanou Frederic , Devambez Marion , Lejeune Jean-Paul , Vincent Christophe , Bonne Nicolas-Xavier 
Published: October 2018

Objective:
To determine whether cervical vestibular evoked myogenic potentials (cVEMPs) are predictive of hearing preservation in patients undergoing vestibular schwannoma removal through middle fossa craniotomy approach.

Study Design:
Retrospective case study.

Setting:
Tertiary referral center.

Patients:
Eighteen patients who underwent a middle fossa craniotomy for vestibular schwannoma (stage I or II of Koos classification) with attempted hearing preservation from January 2008 to February 2016 were retrospectively reviewed.

Intervention:
Pre-surgical cVEMPs test, videonystagmography (caloric test), and magnetic resonance imaging (MRI) as well as a pre- and post-surgical audiometry test.

Main Outcome Measures:
cVEMPs parameters including amplitude asymmetry ratio (AR), P13, and N23 latencies and peak-to-peak amplitude between P13 and N23 waves were calculated. Hearing data were classified according to the AAO-HNS hearing classes. The nerve of origin of the tumor was specified during surgery and the largest tumor diameter was measure on MRI axial plane on T2-CISS weighed images.

Results:
Preoperative amplitude asymmetry ratio was lower (n = 15, Mann–Whitney U test, p < 0.001) in the group with postoperative hearing preservation (n = 11) compared with the group with postoperative hearing preservation failure (n = 4). The positive predictive value of an AR less than 24% to assess postoperative hearing preservation is 91.6%. Tumor size and localization were not correlated with cVEMPs, nor with caloric testing in this group of small-sized intracanalicular vestibular schwannomas.

Conclusions:
Our data suggest that cVEMPs may help predict hearing preservation outcome in vestibular schwannoma surgery via the middle fossa craniotomy approach.
Collaborative Online International Learning to Prepare Students for Multicultural Work Environments
Authors: de Castro A.B. , Dyba Natalia , Cortez Elizabeth D. , Pe Benito Genecar G. 
Published: October 2018

Background
Collaborative Online International Learning (COIL) is a pedagogical approach using digital technology to provide experiential international learning without travel abroad. Through web-based, cross-country intellectual exchange, COIL helps prepare nursing students for increasingly diverse and multicultural health care work environments globally.

Problem
Opportunities to engage in multicultural learning experiences have traditionally relied on intensive study abroad trips, which can be prohibitive for students with limited fiscal resources or who are place-bound.

Approach
A COIL experience for undergraduate nursing students at universities in the United States and the Philippines was designed to fulfill academic degree program goals related to professional communication, collaborative practice, and respect for diversity.

Conclusion
After completing the COIL experience, students expressed valuing shared learning with peers in another country and reported gains in intercultural competence. Our efforts indicated that COIL-style endeavors provide meaningful, rewarding opportunities to engage with others across borders, while enhancing students’ skills to relate positively to an increasingly diverse world.
Can Applications Designed to Evaluate Visual Function Be Used in Different iPads?
Authors: de Fez Dolores , Luque María José , García-Domene Mari Carmen , Caballero Maria Teresa , Camps Vicente J. 
Published: October 2018

SIGNIFICANCE
Apple devices could be suitable for vision tests, provided that the test has been correctly adapted to the device, after considering the spatial and colorimetric characterization of the screen.

PURPOSE
The majority of vision applications has not been developed by vision or colorimetry experts and suffers from conceptual and design errors that may lead average users to an erroneous assessment of their visual capabilities. The reliability of vision tests depends on the accurate generation of the necessary visual stimuli in a particular device. Our aim was to ascertain whether a given color test, designed for a colorimetrically characterized device, might be used in another similar device.

METHODS
We evaluated color reproduction errors in three iPad tablets of different models with Retina screens, using their individual color characterization models and the model derived for another device.

RESULTS
Our results showed, even with this small sample, the high degree of error caused when disregarding the fact that the colorimetric design valid for a given device may not be correct when displayed in another.

CONCLUSIONS
The distortion of the chromatic content may lead to subjects with vision defects to pass as normal or vice versa, compromising diagnosis reliability.
Bilateral Hyperplasia of the Coronoid Process in Pediatric Patients: What is the Gold Standard for Treatment?
Authors: Farronato Marco , Lucchina Alberta Greco , Mortellaro Carmen , Fama Andrea , Galbiati Guido , Farronato Giampietro , Maspero Cinzia 
Published: October 2018

Objectives:
The aim of this systematic review of the literature is to describe treatment options for bilateral coronoid process hyperplasia in pediatric patients, to describe etiologic and diagnostic correlations with the treatment, and to evaluate long-term follow-up treatment outcomes.

Methods:
A systematic revision of the literature was performed in the Medline, PubMed, Cochrane library, and Embase database up to December 5, 2017. Predetermined Medical Subject Heading keywords were used: “bilateral” or “monolateral” and “coronoid” or “coronoid process” and “hyperplasia” and “temporomandibular joint” or “tmj” and “ankylosis” or “trismus” and “treatment.” Results were recorded following PRISMA guidelines.

Results:
The systematic research produced 1459 results excluding duplicates. Two additional studies from “Grey literature” were also considered. After application of inclusion and exclusion criteria, 38 articles were selected for a qualitative synthesis. Data regarding sex and age of presentation were collected and summarized in a study flow diagram.

Conclusion:
It is possible to conclude that early diagnosis is fundamental to restore stomatognathic multifunction. There is lack of longitudinal studies presenting long-term follow-up to determine treatment stability. Coronoidectomy might be considered gold standard treatment for this pathologic condition.
Reconstruction of a Calvarial Wound Complicated by Infection: Comparing the Effects of Biopatterned Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor
Authors: Brooker Jack E. , Camison Liliana B. , Bykowski Michael R. , Hurley Ethan T. , Yerneni Saigopalakrishna S. , Campbell Phil G. , Weiss Lee E. , Mooney Mark P. , Cray James , Gilbert James R. , Cooper Gregory M. , Losee Joseph E. 
Published: October 2018

Abstract
Bone morphogenetic protein 2 (BMP2) bioprinted on biological matrix induces osseous regeneration in large calvarial defects in rabbits, both uncomplicated and scarred. Healing in unfavorable defects scarred from previous infection is decreased due in part to the lack of vascularity. This impedes the access of mesenchymal stem cells, key to osseous regeneration and the efficacy of BMP2, to the wound bed. The authors hypothesized that bioprinted vascular endothelial growth factor (VEGF) would augment the osseous regeneration achieved with low dose biopatterned BMP2 alone. Thirteen New Zealand white rabbits underwent subtotal calvariectomy using a dental cutting burr. Care was taken to preserve the underlying dura. A 15 mm × 15 mm flap of bone was cut away and incubated in a 1 × 108 cfu/mL planktonic solution of S aureus before reimplantation. After 2 weeks of subsequent infection the flap was removed and the surgical wound debrided followed by 10 days of antibiotic treatment. On postoperative day 42 the calvarial defects were treated with acellular dermal matrix bioprinted with nothing (control), VEGF, BMP2, BMP2/VEGF combined. Bone growth was analyzed with serial CT and postmortem histology. Defects treated with BMP2 (BMP2 alone and BMP2/VEGF combination) showed significantly greater healing than control and VEGF treated defect (P < 0.5). Vascular endothelial growth factor treated defect demonstrated less healing than control and VEGF/BMP2 combination treatments achieved less healing than BMP2 alone though these differences were nonsignificant. Low dose BMP2-patterned acellular dermal matrix improves healing of scarred calvarial defects. Vascular endothelial growth factor at the doses applied in this study failed to increase healing.
Bucket-Handle Bipedicled Scalp Flaps for Coverage of Cranial Constructs in Cranioplasty
Authors: Devulapalli Chris , Mercaitis Orion Paul , Orbe Maria , Salgado Christopher J. 
Published: October 2018

Abstract
Composite frontal scalp defects involving the frontal bone and full thickness scalp can pose a reconstructive challenge. Often, they necessitate the use of microsurgical free tissue transfer, which can be physiologically demanding in high-risk patients with multiple comorbidities, with exposure to prolonged general anesthesia time and increased surgical morbidity. The experience of a single surgeon was reviewed with reconstruction of composite frontal scalp wounds in 4 patients with structural framework and a bipedicled scalp advancement (ie, “bucket handle”) flap, thus obviating the need for free tissue transfer. All 4 patients demonstrated complete wound healing by final follow-up, without need for further reoperations or ulcer recurrence. In face of composite frontal scalp defects in less than ideal candidates for lengthy microsurgical flap procedures, the bucket-handle flap can provide a simple and reliable reconstructive option.
Unilateral Cleft Lip Repair: Assessment of Outcome of Olokun-Olaitan Vermillion Flap Approach
Authors: Aluko-Olokun Bayo , Olaitan Ademola Abayomi , Olubi Olawale , Adediran Olanrewaju Moses 
Published: October 2018

Abstract
This study aimed to assess the outcome of our novel free-hand approach. Numerous cleft lip repair techniques exist, all of which involve incisions on skin and excision of tissue. Unilateral cleft lip is the result of failure of migration of orofacial tissues in-utero. Cleft lip repair should ideally involve an approach that simulates nature by avoiding skin incision and tissue excision, as these are not known to occur in the normal natural sequence of events.
Without incising skin or excising any tissue, vermillion flaps were raised exposing the muscular layer and edges of skin and mucosa. Similar tissue types were advanced and sutured across the cleft, replicating what should have occurred normally.
All 28 patients (100%) treated using our technique had competent lips. Acceptable symmetry of the vermillion was achieved in 24 (85.7%) of the patients. Lip symmetry was judged to be acceptable in 22 (78.6%). Symmetry of the nose was acceptable in 18 (64.3%) of patients.
The Olokun-Olaitan vermillion flap approach proved effective in the repair of unilateral cleft lip, as it compared very favorably with results obtained using Millard's technique.
Tongue Lip Adhesion in the Treatment of Robin Sequence: Respiratory, Feeding, and Surgical Outcomes
Authors: Mermans Joline F. , Lissenberg-Witte Birgit I. , Van Gogh Christine D.L. , Broers Chantal J.M. , Van Hagen Johanna M. , Strijers Rob L.M. , Don Griot Johan P.W. 
Published: October 2018

Objective:
Objective evaluation of the efficacy of tongue lip adhesion (TLA) in the management of Robin sequence (RS).

Study Design:
Retrospective cohort study.

Setting:
Tertiary referral hospital.

Patients, Participants:
The craniofacial database of Amsterdam UMC, Vrije Universiteit Amsterdam was searched to identify infants with RS who underwent tong lip adhesion (TLA). Forty-one RS infants who underwent TLA from 1993 to 2016 were identified.

Interventions:
TLA.

Main Outcome Measure:
The outcome measures were pre- and postoperative polysomnography results, nutritional status, weight gain, age at operation, hospital stay length, extubation time after TLA, and complications.

Results:
Forty-one RS patients were included who had TLA at an average age of 26.6 days. In 16 cases a pre- and postoperative polysomnography was performed. In 13 of these cases (81.3%) improvement was observed, in 2 (12.5%) the results were inconclusive, and in 1 (6.3%) no improvement was seen. Patients were extubated after a mean of 2.2 days.
The mean hospital stay was 40.2 days. Reintervention was needed in 7 patients because of a wound dehiscence. The mean age of TLA release was 9.7 months. At discharge, 9 (22%) children still needed total nutritional support for persistent feeding difficulties. The average growth from birth to adhesion release was 4.6 kg.

Conclusion:
This cohort demonstrates that TLA is a successful procedure in children with RS in terms of respiratory, feeding, and growth outcome. Only minor complications were seen in our cohort.
Assessment of Coagulation Homeostasis in Blunt, Penetrating, and Thermal Trauma: Guidance for a Multicenter Systems Biology Approach
Authors: Shupp Jeffrey W. , Brummel-Ziedins Kathleen E. , Cohen Mitchell J. , Freeman Kalev , Hammamieh Rasha , Mudunuri Uma S. , Orfeo Thomas , Moffatt Lauren T. , Brownstein Bernard H. , Mann Kenneth G. , Jett Marti , Pusateri Anthony E. 
Published: October 2018

ABSTRACT

Introduction:
Provisioning care for traumatically injured patients makes conducting research very proximal to injury difficult. These studies also inherently have regulatory barriers to overcome. Here we outline a protocol for acute-phase enrollment of traumatically injured patients into a prospective observational clinical trial with precise and comprehensive sample acquisition in support of a systems biology approach to a research study.

Methods:
Experts in trauma, burn, blood coagulation, computational biology, and integrative systems biology developed a prospective study that would capture the natural history of coagulation pathology after traumatic injury. Blood was sampled at admission and serial time points throughout hospitalization. Concurrently, demographic and outcomes data were recorded and on-site point-of-care testing was implemented. Protocols were harmonized across sites and sampling protocols validated through demonstration of feasibility and sample quality assurance testing. A novel data integration platform was developed to store, visualize, and enable large-scale analysis of empirical and clinical data. Regulatory considerations were also addressed in protocol development.

Results:
A comprehensive Manual of Operations (MOO) was developed and implemented at 3 clinical sites. After regulatory approval, the MOO was followed to collect 5,348 longitudinal samples from 1,547 patients. All samples were collected, processed, and stored per the MOO. Assay results and clinical data were entered into the novel data management platform for analyses.

Conclusion:
We used an iterative, interdisciplinary process to develop a systematic and robust protocol for comprehensive assessment of coagulation in traumatically injured patients. This MOO can be a template for future studies in the acute setting.
DC-SIGN Expression in Intestinal Epithelial Cells Regulates Sepsis-Associated Acute Intestinal Injury Via Activating ERK1/2-NF-κB/P65 Signaling
Authors: Chen Weiwei , Ma Li , Li Ranran , Huang Shunwei , Xie Rongli , Chen Ying , Zhao Bing , Fei Jian , Qu Hongping , Chen Hao , Mao Enqiang , Chen Er-zhen 
Published: October 2018

ABSTRACT

Objective:
The aim of the study was to investigate the role of dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) in intestinal epithelial cells (IECs) in regulating sepsis-induced acute intestinal injury and systemic inflammatory response.

Methods:
To induce sepsis condition, Male C57BL/6 mice were exposed to cecal ligation and puncture (CLP) in vivo, whereas a normal human IECs line (FHs74Int) was stimulated with lipopolysaccharide (LPS) in vitro. DC-SIGN siRNA pretreatment was used to knock down DC-SIGN expression both in vivo and in vitro. The expression of DC-SIGN was detected by western blot and immunohistochemistry. The expression of total and phosphorylation of ERK1/2 and NF-κB/p65 was examined by western blot. The levels of cytokines in serum and culture supernatant were measured by ELISA. The survival rate and organ injures of septic mice were also assessed.

Results:

In vivo, DC-SIGN expression in mouse IECs was time-dependently upregulated by CLP. CLP-induced phosphorylation of ERK1/2 and NF-κB/p65 was effectively inhibited by DC-SIGN siRNA pretreatment, leading to the decrease of systemic inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-10, and IFN-γ), which alleviated multiple organ injuries and increased the survival rate of septic mice. In vitro, DC-SIGN expression in FHs74Int was significantly upregulated by LPS stimulation in a time- and dose-dependent manner. DC-SIGN knockdown abolished LPS-induced ERK1/2 and NF-κB/p65 phosphorylation, resulting in the decrease of cytokines release by FHs74Int.

Conclusions:
Sepsis-induced DC-SIGN expression in IECs plays a significant role in regulating acute intestinal injury and systemic inflammatory response. The inhibition of DC-SIGN exhibited protective effects on sepsis-associated organ injury and systemic inflammation.