bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Variability in Triage Nursing Workload: Insights From a Multicentre Observational Study
Authors: Zaboli Arian , Brigo Francesco , Brigiari Gloria , Turcato Gianni 
Published: November 2024

ABSTRACTAimAlthough there has been a significant amount of research on nurse workloads in hospital environments, there has been a lack of comprehensive investigation of the workload of triage nurses. This study assesses the workload fluctuations of triage nurses in various emergency departments in the same region and examines how workload varies based on emergency department visit volumes and seasonal fluctuations.DesignThe study is a retrospective, multicentre, observational study from January 1, 2019, to December 31, 2023, in seven Italian emergency departments, gathering information on all patients who went through the triage process.MethodsWe documented the number of nurses present throughout each shift and adjusted the data to account for the number of patients attended to by each triage nurse per shift. The EDs were classified into high‐inflow, medium‐inflow and low‐inflow categories according to the annual number of patients they served.ResultsThe study included 1,223,331 emergency department triage assessments. During daytime shifts, triage nurses in high‐inflow emergency departments assessed a median of 74 patients, while those in medium‐inflow and low‐inflow emergency departments assessed 63 and 32 patients, respectively. During nighttime shifts, triage nurses in high‐inflow emergency departments assessed 26 patients, compared to 14 in medium‐inflow and 5 in low‐inflow emergency departments. Significant seasonal fluctuations in the workload of triage nurses were observed.ConclusionsThis study reveals substantial disparities in the number of patients triage nurses assess, which vary according to emergency department patient inflow volumes and seasonal factors. The findings emphasise the need for more standardised and equitable workload distribution among triage nurses. Future research should aim to establish a systematic nurse staffing model for triage to ensure manageable workloads and maintain patient safety.Reporting MethodThe Strengthening the Reporting of Observational Studies in Epidemiology was used.Patient and Public ContributionNo patient or public contribution.
Somatostatin receptor‐linked α‐particle therapy in neuroendocrine tumours
Authors: Navalkissoor Shaunak , Grossman Ashley 
Published: November 2024

AbstractThe incidence and prevalence of neuroendocrine tumours (NETs) are on the rise, but to date, only complete surgical resection is curative. Among the various therapeutic options for metastatic disease, peptide receptor radionuclide therapy (PRRT), linking a radioactive moiety to an octreotide derivative, has been shown to be highly efficacious and a well‐tolerated therapy, improving progression‐free survival and prolonging overall survival. Nevertheless, complete responses are rare, and the current β‐particle emitters have non‐optimal radiobiological properties. A new generation of α‐particle‐emitting radionuclides is being developed, with the advantages of very high energy and a short path length. We survey the most recent developments in this field, summarising the result of currently performed studies in this potentially ground‐breaking novel form of therapy for NETs.
Pilot study of the effect of surgical menopause on bone mineral density and quality in patients with gynecological malignancies
Authors: Matsuno Kanae , Ueda Kazu , Saito Mitsuru , Kamii Misato , Tsuda Akina , Kawabata Ayako , Morikawa Asuka , Okamoto Aikou 
Published: November 2024

AbstractAimTo investigate the effects of surgical menopause on bone mineral density and bone quality because bilateral salpingo‐oophorectomy for the treatment of gynecological malignancies is common even in premenopausal patients. This study is prospective one of bone mineral density and quality measurements after surgery for perimenopausal gynecologic malignancies.MethodsIn 50 women who underwent surgical menopause for a diagnosis of gynecological malignancies, bone mineral density (BMD), blood levels of tartrate‐resistant acid phosphatase 5b (TRACP‐5b) and bone‐specific alkaline phosphatase (BAP) as bone metabolism markers, and urinary pentosidine level as bone quality marker were measured before surgery and at multiple points up to 24 months after surgery.ResultsIn a group of 22 patients who did not undergo hormone replacement therapy (HRT) (HRT− group), BMD of the lumbar spine and total hip continued to decrease significantly from 6 months postoperatively. Percentages of changes in BMD progressively increased over time after surgery. TRACP‐5b and urinary pentosidine levels significantly increased 6 months postoperatively compared with preoperative levels. Comparisons between 10 patients who underwent HRT (HRT+ group) and the HRT− group revealed significant reductions in the percentage of change in lumbar spine BMD only and TRACP‐5b and urinary pentosidine levels 12 months postoperatively in the former group.ConclusionsIn this pilot study, we showed that BMD and bone‐related markers are altered in patients with surgical menopause. It also suggested that HRT may reduce these influences on bone metabolism.
Intraductal Papillary Mucinous Neoplasm: New Insights Into Its Origin and Nomenclatures
Authors: Soares Andresa Borges , Teixeira Lucas Novaes , Melo Joana Vitória Batista Costa , Passador Santos Fabrício , Freitas Nadir Severina , de Araújo Ney Soares , de Araújo Vera Cavalcanti 
Published: November 2024

ABSTRACTBackgroundMucinous cells can be detected sporadically or may constitute the primary tumor component in salivary gland tumors, as observed in the intraductal papillary mucinous neoplasm (IPMN). This low‐grade tumor is composed of mucinous columnar cells organized into papillary cystic structures. The present study aimed to compare the mucous cells in IPMN with mucous cells present in mucoepidermoid carcinoma (MEC) and papillary cystadenoma (PC).MethodsImmunohistochemistry analysis was carried out to compare the mucous cells in IPMN with the sporadic mucous cells in MEC (n = 4) and PC (n = 3).ResultsThe results indicated that IPMN cells were positive for CK7, CK18, DOG1, and NKX3.1 and negative for CK14, SMA, and p63. The mucous cells in both MEC and PC were positive for CK7 and negative for CK18, SMA, DOG1, and NKX3.1. The positive expression of CK14 and p63 revealed the presence of basal cells both in PC, cystic areas of MEC, and normal mucous salivary glands.ConclusionThe immunohistochemical profile of IPMN closely resembles that of the mucous cells of the minor salivary glands yet differs from the mucous cells observed in MEC and PCX. This suggests that IPMN is probably derived from the transformation of secretory cells of the minor mucous salivary gland and has no rimming/basal cells. For this reason, we propose that this tumor is designated as mucous acinic cell carcinoma.
Personality and Meat Consumption Among Romantic Partners in Daily Life
Authors: Tan Nicholas Poh‐Jie , Trenkenschuh Maxim , Ackermann Dana , Betancourt Leyla Anina Rosero , Bleidorn Wiebke , Hopwood Christopher J. 
Published: November 2024

ABSTRACTObjectiveEating is often a social activity that can be influenced by others, particularly in close relationships when dietary preferences reflect underlying value differences. We sought to examine the personality traits of meat‐eating couples who differ in their preferences for meat.MethodWe recruited Swiss romantic couples in which one partner typically consumed more meat than the other (N = 272, couples = 136). At baseline, participants completed survey measures of self‐ and informant‐rated personality traits at the domain (e.g., agreeableness) and aspect level (e.g., compassion) and meat consumption. Participants then completed 28 daily meal surveys about their meat consumption.ResultsAmong high‐meat eating partners, those higher in openness/intellect and compassion ate less meat. Additionally, higher intellect among low‐meat eating partners predicted lower meat consumption among high‐meat eating partners.ConclusionsThese findings replicate evidence that personality plays an important role in meat‐eating and extend this evidence to meat consumption in a relational context.
The Myth of Agreement
Authors: Kaczmarczyk Michal Roch 
Published: November 2024

ABSTRACTContemporary ontological constructivism often rests on the belief that social reality emerges from tacit agreements, underpinning mutual expectations and trust. In social theory, the concept of agreement has evolved from explicit social contracts to normative consensus and the idea of tacit knowledge that subtly binds social actors. This article challenges this prevailing approach by dissecting various constructivist positions and exposing the implications of agreement‐based ontological constructivism on our understanding of culture, norms, and society. The author revisits an alternative perspective, claiming that human society is equally a structure of disagreement. Emphasizing disagreement advocates for a realistic social theory and highlights the vital role of fiction in shaping social life.
An Assessment of the Knowledge Attitude and Practices (KAP) on Biosecurity and Best Management Practices in Nile Tilapia (Oreochromis niloticus) Cage Aquaculture in Lake Victoria, Kenya
Authors: Mwainge V. , Vang A. , Ogwai C. , Obuya J. , Benhaïm D. 
Published: November 2024

ABSTRACTAs aquaculture intensifies, maintaining conducive conditions for sustainable production becomes a key priority. The expansion in farm number and perfarm production puts pressure on the environment and increases susceptibility of the cultured fish to disease, leading to production loss by the investors. This study was conducted in cage aquaculture systems located in three riparian counties in Lake Victoria, Kenya to investigate the combined role of biosecurity and adherence to best management practices (BMPs) by looking at the knowledge, attitude, and practices (KAP) of the cage aquaculture farmers. Additionally, it examined the link between biosecurity, BMPs, and water quality in the context of promoting fish health and preventing fish kills in the cage aquaculture of Nile tilapia in Lake Victoria, Kenya. Gulf and open water locations were included in the study design. A semi‐structured questionnaire was used to gather qualitative information on the KAP of fish farmers to biosecurity and BMPs in the cage aquaculture farms. For water quality analysis, quantitative data was utilised. Results showed that the farmers had a positive attitude towards various biosecurity and BMP concepts and a moderate level of knowledge, but the practices on the farm were not in concurrence with both their attitudes and knowledge. Using a customised aquaculture performance index score, which assessed compliance to some BMPs and biosecurity, only 8% of the farms under investigation had a good score, while 24% had an average score and the majority (68%) had a poor score. Additionally, a good aquaculture performance index score was inversely related to ammonia levels. This finding suggests the need to locate cage fish farms in areas with better water circulation. The study highlights the need for capacity building on the importance of adherence to biosecurity and BMPs in the cage aquaculture of Nile tilapia in the lake for enhanced productivity and sustainability of the lake ecosystem.
Transient Receptor Potential Melastatin 8 Contributes to Cystitis‐Induced Neuronal Sprouting and Pain Hypersensitivity Through AKT/mTOR Signaling Pathway in Interstitial Cystitis/Bladder Pain Syndrome
Authors: Wu Liyang , Chang Ran , Zhang Peng 
Published: November 2024

ABSTRACTObjectivesThe aim of this study was to investigate the mechanism of TRPM8 in neuroproliferation and pain, as well as the relevance of the Akt/mTOR signaling pathway in mice with IC/BPS.MethodsThe model of IC/BPS was established in wild and TRPM8−/− mice. The mechanical sensitivity was measured. The number of neurite segments, length of neurites, and density of neurites were all counted. IL‐6 and norepinephrine levels were detected by ELISA, Western blot was used to detect protein levels of TRPM8, Akt, p‐Akt, mTOR, p‐mTOR. Immunofluorescence was used to detect TRPM8 expression and distribution in neurites, neurons, and sensory nerves in mouse bladder tissue.ResultsPain threshold in the IC/BPS group was decreased, and neurite segments, length, and density were all significantly enhanced when compared to the control group. The parameters in the IC/BPS model + Menthol group were more statistically significant. Neurite number and density were lower in TRPM8 knockout‐model mice than in IC/BPS model mice. The expression of TRPM8 and the ratios of p‐Akt/Akt and p‐mTOR/mTOR rose in the IC/BPS model group. In TRPM8 knockout‐model mice, the ratios of p‐Akt/Akt and p‐mTOR/mTOR were not substantially different from those in the control group. TRPM8 knockout‐model mice had considerably lower levels of serum IL‐6 and urine norepinephrine than IC/BPS model mice.ConclusionsTRPM8 can induce pain hypersensitivity and sensory nerve proliferation by activating Akt/mTOR pathway and raising the expression of IL‐6 and norepinephrine in IC/BPS models. These findings offer new perspectives on IC/BPS treatment.
Damage detection for railway bridges using time‐frequency decomposition and conditional generative model
Authors: Lee Jun S. , Park Jeongjun , Kim Hyun Min , Kim Robin Eunju 
Published: November 2024

AbstractA novel damage detection model, which utilizes the spatiotemporal characteristics of the acceleration data, is proposed to assess the structural integrity of railway bridges. For this, the measured acceleration data are decomposed into several intrinsic mode functions (IMFs) using the sparse random mode decomposition model. The generated IMFs are subsequently integrated into the enhanced time series conditional generative adversarial network model to identify possible damage in bridges across various frequency bands. The influence of environmental and operational variables (EOVs), particularly temperature fluctuations, was also investigated. The proposed model was verified using both numerical and experimental data from a plate girder bridge. Further validation was conducted using the Z24 bridge dataset, and damage cases under the influence of EOVs were successfully predicted. Throughout the validation process, various anomaly metrics were introduced to establish a threshold value, and a covariance‐based time domain metric was proven to be the most effective in our cases.
The American Neurogastroenterology and Motility Society Gastroparesis Cardinal Symptom Index‐Daily Diary (ANMS GCSI‐DD): Psychometric validation and meaningful change threshold in patients with idiopathic or diabetic gastroparesis
Authors: Chen Yaozhu J. , Coyne Karin S. , Rodriguez Danielle , Schulz Andrea , Huh Susanna Y. , Kuo Braden , Camilleri Michael , Tack Jan , Parkman Henry P. 
Published: November 2024

AbstractIntroductionThe American Neurogastroenterology and Motility Society Gastroparesis Cardinal Symptom Index‐Daily Diary (ANMS GCSI‐DD) is a patient‐reported outcome (PRO) instrument for gastroparesis. This study evaluated the psychometric properties of the ANMS GCSI‐DD and determined a meaningful change threshold using the data from a phase 2b trial in adults with moderate‐to‐severe idiopathic or diabetic gastroparesis (DG).MethodsThe psychometric properties of ANMS GCSI‐DD were analyzed using other clinician‐ and patient‐reported outcomes from 242 patients during the 12‐week trial. Trial exit interviews were conducted in a cohort of 32 patients to capture their perspectives on meaningful change from the trial.ResultsANMS GCSI‐DD demonstrated good performance: unidimensionality scores exhibited good fit; internal consistency reliability was >0.70; test–retest reliability was above 0.90, and convergent validity showed strong correlations (0.70–0.90) with overall severity rating and moderate correlations (0.30–0.70) with other outcomes. ANMS GCSI‐DD scores discriminated among groups with varying severity of gastroparesis symptoms in known‐groups validity (p < 0.001) and were responsive to symptom improvement. Triangulation of the quantitative anchor‐based estimates of 0.9–1.4 category points as a meaningful change in the ANMS GCSI‐DD composite score, and the qualitative exit interview findings of 0.5–1.5 as meaningful change, supports a one‐point change on a five‐point scale (0–4) as the meaningful change threshold.ConclusionThe ANMS GCSI‐DD is a reliable and valid PRO instrument to employ in clinical development for patients with moderate‐to‐severe idiopathic or DG, and a one‐point score change in the ANMS GCSI‐DD composite score is recommended as a meaningful change threshold of symptom change.
Do children with dysphagia and normal esophageal motility according to Chicago Classification always have “normal” esophageal motility?
Authors: Kovacic Karlo , Kern Mark , Li B U.K. , Vang Mychoua , Noe Joshua , Shaker Reza 
Published: November 2024

AbstractBackgroundInternationally adopted Chicago Classification (CC) criteria based on adult normative data have been used to diagnose children with esophageal motility disorders undergoing high‐resolution esophageal manometry (HREM). The aim of this study was to compare HREM parameters of children without dysphagia and children with dysphagia and normal findings according to CC.MethodsHREM metrics of 41 children (13.2 (9–18) years; 20 female) without dysphagia and 41 children (13.7 (8–18) years; 30 female) with dysphagia and normal diagnosis according to CC were compared. Analyzed data included resting and integrated relaxation pressures (IRP) of upper (UES) and lower (LES) esophageal sphincters, esophageal peristaltic contractile integrals, transition zone (TZ) gaps, distal latency (DL), and manometric esophageal length to height ratio (MELH). 95%ile normative cutoffs were calculated from the cohort without dysphagia.Key ResultsProximal contractile integral (PCI), UES and LES mean resting and IRP were not significantly different between the cohorts (p > 0.3). On the contrary, distal contractile integral (DCI), TZ gap and MELH were notably different with p = 0.0002, p = 0.027, and p = 0.033 respectively. According to 95%ile normative cutoffs of DCI, TZ gap and MELH, in cohort with dysphagia 27%, 15%, and 22% of patients respectively were not normal.Conclusion & InferencesFirst study ever to compare HREM parameters of children without dysphagia to children with dysphagia. Considerable proportion of children with dysphagia may be underdiagnosed according to the adult criteria. This emphasizes the need for universally accepted child‐specific diagnostic protocols and norms.
“Liver Clots” in Periodontology: A 10‐Year Clinical Experience
Authors: Reddy Saravanan Sampoornam Pape , Francis Delfin Lovelina , Harish Ruchi , Raja Kumara , Chopra Sukhbir Singh 
Published: November 2024

ABSTRACTObjectives“Liver clots” are an uncommon complication following periodontal surgery, characterized by their distinctive gelatinous consistency and color resembling 'liver' tissue. Despite anecdotal reports, there is a lack of comprehensive evidence in the literature regarding its incidence, etiopathogenesis and optimal management strategies. This study aimed to address this knowledge gap by retrospectively analyzing cases to provide insights into this unusual post‐operative complication.Materials and MethodsIn this retrospective descriptive study, data spanning a decade (June 2013–June 2024) were collected from various dental centres. The data included patient demographics, medical history, surgical procedures performed, occurrence of “liver clot” formation, management measures and treatment outcomes.ResultsThe 10‐year retrospective data revealed a 2.03% incidence of “liver clots” among various periodontal procedures. The highest occurrence was observed following dental extractions, followed by periodontal surgical procedures. The observations also indicated a higher frequency in systemically healthy individuals.Conclusion“Liver clot” formation is a rare, but specific complication after periodontal surgery. Minimally invasive management approaches are effective, highlighting the importance of vigilance and prompt intervention for optimal patient outcomes. Further research is warranted to elucidate the exact etiopathogenesis and to establish evidence‐based management protocols for this unusual complication.
The Globalization of International Migration? A Conceptual and Data‐Driven Synthesis
Authors: Ha Jasmine Trang , DeWaard Jack , Abel Guy , Tsuchiya Kazumi , Pinchoff Jessie , Levesque Christopher , Price Kobie 
Published: November 2024

AbstractAlthough the globalization of international migration is commonly accepted as a general tendency in contemporary migration patterns (de Haas, Castles, and Miller 2020, 9), the corresponding body of empirical evidence is mixed and fragmented. Our review of global migration patterns over the past half‐century highlights how the theories, expectations, and ultimately findings may vary depending on the specific definitions, vantage points, and measures being used. In this paper, we provide a simpler and integrated account of the globalization of international migration that includes a corresponding empirical template to quantify the relative importance of two processes at work: the intensity and connectivity of international migration. Using recent estimates of country‐to‐country migration flows every five years from 1990–1995 to 2015–2020, our analysis using demographic decomposition and group‐based multitrajectory modeling highlights the dynamic relationship between intensity and connectivity from both the global and country vantage points. Our work in this paper provides a starting point in the form of a much‐needed empirical template, one that is also highly flexible and customizable, for future research on the globalization of international migration to coalesce around and use going forward.
TaWRKY17 Interacts With TaWRKY44 to Promote Expression of TaDHN7 for Salt Tolerance in Wheat
Authors: Jia Zhenzhen , Zeng Tuo , Gu Lei , Wang Hongcheng , Zhu Bin , Ren Mingjian , Du Xuye 
Published: November 2024

ABSTRACTWheat is a crucial food crop, yet its production is continually threatened by abiotic stresses, particularly salt stress. Understanding the molecular mechanisms by which wheat responds to salt stress is essential for developing salt‐tolerant varieties. In this study, we investigated the molecular pathway involving the wheat TaDHN7 in response to salt stress. The overexpression of TaDHN7 enhances salt tolerance and reactive oxygen species (ROS) scavenging in wheat, while the knockout of TaDHN7 significantly impairs salt tolerance. Furthermore, we identified that TaWRKY44 promotes the expression of TaDHN7 by binding to the W‐box within the TaDHN7 promoter. Additionally, TaWRKY17 interacts with TaWRKY44, and this interaction enhances the protein stability of TaWRKY44 under salt stress, thereby enhancing its transcriptional regulatory capacity on TaDHN7. This study elucidates the TaWRKY17‐TaWRKY44‐TaDHN7 pathway in response to salt stress in wheat, providing valuable insights for the development of salt‐tolerant wheat cultivars.