bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose Tissue Distribution and Cardiovascular Disease Risk Among Breast Cancer Survivors
Authors: Cespedes Feliciano Elizabeth M. , Chen Wendy Y. , Bradshaw Patrick T. , Prado Carla M. , Alexeeff Stacey , Albers Kathleen B. , Castillo Adrienne L. , Caan Bette J. 
Published: August 2019

PURPOSE Cardiovascular disease (CVD) is a major source of morbidity and mortality among breast cancer survivors. Although body mass index (BMI) is associated with CVD risk, adipose tissue distribution may better identify patients with a high risk of CVD after breast cancer. METHODS Among 2,943 patients with nonmetastatic breast cancer without prior CVD, we used International Classification of Diseases (9th and 10th revisions) codes to identify incidence of nonfatal stroke, myocardial infarction, heart failure, or CVD death. From clinically acquired computed tomography scans obtained near diagnosis, we measured visceral adiposity (centimeters squared), subcutaneous adiposity (centimeters squared), and intramuscular adiposity (fatty infiltration into muscle [Hounsfield Units, scored inversely]). We estimated hazard ratios (HRs) and 95% CIs per SD increase in adiposity accounting for competing risks and adjusting for demographics, smoking, cancer treatment, and pre-existing CVD risk factors. RESULTS Mean (SD) age was 56 (12) years. Over a median follow-up of 6 years, 328 CVD events occurred. Each SD increase in visceral or intramuscular adiposity was associated with an increase in CVD risk (HR, 1.15 [95% CI, 1.03 to 1.29] and HR, 1.21 [95% CI, 1.06 to 1.37]), respectively). Excess visceral and intramuscular adiposity occurred across all BMI categories. Among normal-weight patients, each SD greater visceral adiposity increased CVD risk by 70% (HR, 1.70 [95% CI, 1.10 to 2.62]). CONCLUSION Visceral and intramuscular adiposity were associated with increased CVD incidence after breast cancer diagnosis, independent of pre-existing CVD risk factors and cancer treatments. The increased CVD incidence among normal-weight patients with greater visceral adiposity would go undetected with BMI alone. Measures of adipose tissue distribution may help identify high-risk patients and tailor CVD prevention strategies.
Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk: An Endocrine Society* Clinical Practice Guideline
Authors: Rosenzweig James L , Bakris George L , Berglund Lars F , Hivert Marie-France , Horton Edward S , Kalyani Rita R , Murad M Hassan , Vergès Bruno L 
Published: August 2019

AbstractObjectiveTo develop clinical practice guidelines for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes mellitus (T2DM) in individuals at metabolic risk for developing these conditions.ConclusionsHealth care providers should incorporate regular screening and identification of individuals at metabolic risk (at higher risk for ASCVD and T2DM) with measurement of blood pressure, waist circumference, fasting lipid profile, and blood glucose. Individuals identified at metabolic risk should undergo 10-year global risk assessment for ASCVD or coronary heart disease to determine targets of therapy for reduction of apolipoprotein B–containing lipoproteins. Hypertension should be treated to targets outlined in this guideline. Individuals with prediabetes should be tested at least annually for progression to diabetes and referred to intensive diet and physical activity behavioral counseling programs. For the primary prevention of ASCVD and T2DM, the Writing Committee recommends lifestyle management be the first priority. Behavioral programs should include a heart-healthy dietary pattern and sodium restriction, as well as an active lifestyle with daily walking, limited sedentary time, and a structured program of physical activity, if appropriate. Individuals with excess weight should aim for loss of ≥5% of initial body weight in the first year. Behavior changes should be supported by a comprehensive program led by trained interventionists and reinforced by primary care providers. Pharmacological and medical therapy can be used in addition to lifestyle modification when recommended goals are not achieved.
Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes
Authors: Ghosn Eliver , Yoshimoto Momoko , Nakauchi Hiromitsu , Weissman Irving L. , Herzenberg Leonore A. 
Published: August 2019

ABSTRACT
The current paradigm that a single long-term hematopoietic stem cell can regenerate all components of the mammalian immune system has been challenged by recent findings in mice. These findings show that adult tissue-resident macrophages and innate-like lymphocytes develop early in fetal hematopoiesis from progenitors that emerge prior to, and apparently independently of, conventional long-term hematopoietic stem cells. Here, we discuss these recent findings, which show that an early and distinct wave of hematopoiesis occurs for all major hematopoietic lineages. These data provide evidence that fetal hematopoietic progenitors not derived from the bona fide long-term hematopoietic stem cells give rise to tissue-resident immune cells that persist throughout adulthood. We also discuss recent insights into B lymphocyte development and attempt to synthesize seemingly contradictory recent findings on the origins of innate-like B-1a lymphocytes during fetal hematopoiesis.
Serotonin receptor oligomerization regulates cAMP-based signaling
Authors: Prasad Sonal , Ponimaskin Evgeni , Zeug Andre 
Published: August 2019

ABSTRACT
Protein–protein interaction is often investigated using quantitative molecular microscopy with Förster resonant energy transfer (FRET). Here, we combined ‘linear unmixing FRET’ (lux-FRET) with the simultaneous application of a FRET-based biosensor for cAMP to investigate the oligomerization between the 5-HT7 receptor (5-HT7R, also known as HTR7) and the 5-HT1A receptor (5-HT1AR, also known as HTR1A) and its importance for cAMP signaling. We found that the 5-HT7R not only stimulates cAMP production, but also forms hetero-oligomers with 5-HT1AR, which blocks the inhibitory effect of the latter. 5-HT7R signaling, however, is not affected by this hetero-oligomerization. By modeling the kinetics of intracellular cAMP level changes in relation to the 5-HT7R:5-HT1AR stoichiometry, we were able to decipher the complex signaling characteristics of endogenous serotonin receptors in cultured hippocampal neurons. Our findings indicate that serotonergic signaling is not only modulated by the concentration of an individual receptor but also by its specific interaction with other receptors in endogenous systems. We conclude that the regulated ratio of serotonin receptors in immature and mature neurons may be critically involved in both the onset and response to treatments of psychiatric diseases, such as anxiety and depression.
Glucocorticoids delay RAF-induced senescence promoted by EGR1
Authors: Carvalho Cyril , L'Hôte Valentin , Courbeyrette Régis , Kratassiouk Gueorgui , Pinna Guillaume , Cintrat Jean-Christophe , Denby-Wilkes Cyril , Derbois Céline , Olaso Robert , Deleuze Jean-François , Mann Carl , Thuret Jean-Yves 
Published: August 2019

ABSTRACT
Expression of hyperactive RAF kinases, such as the oncogenic B-RAF-V600E mutant, in normal human cells triggers a proliferative arrest that blocks tumor formation. We discovered that glucocorticoids delayed the entry into senescence induced by B-RAF-V600E in human fibroblasts, and allowed senescence bypass when the cells were regularly passaged, but that they did not allow proliferation of cells that were already senescent. Transcriptome and siRNA analyses revealed that the EGR1 gene is one target of glucocorticoid action. Transcription of the EGR1 gene is activated by the RAF-MEK-ERK MAPK pathway and acts as a sensor of hyper-mitogenic pathway activity. The EGR1 transcription factor regulates the expression of p15 and p21 (encoded by CDKN2B and CDKN1A, respectively) that are redundantly required for the proliferative arrest of BJ fibroblasts upon expression of B-RAF-V600E. Our results highlight the need to evaluate the action of glucocorticoid on cancer progression in melanoma, thyroid and colon carcinoma in which B-RAF-V600E is a frequent oncogene, and cancers in which evasion from senescence has been shown.
The Chlamydomonas flagellar membrane glycoprotein FMG-1B is necessary for expression of force at the flagellar surface
Authors: Bloodgood Robert A. , Tetreault Joseph , Sloboda Roger D. 
Published: August 2019

ABSTRACT
In addition to bend propagation for swimming, Chlamydomonas cells use their flagella to glide along a surface. When polystyrene microspheres are added to cells, they attach to and move along the flagellar surface, thus serving as a proxy for gliding that can be used to assay for the flagellar components required for gliding motility. Gliding and microsphere movement are dependent on intraflagellar transport (IFT). Circumstantial evidence suggests that mechanical coupling of the IFT force-transducing machinery to a substrate is mediated by the flagellar transmembrane glycoprotein FMG-1B. Here, we show that cells carrying an insertion in the 5′-UTR of the FMG-1B gene lack FMG-1B protein, yet assemble normal-length flagella despite the loss of the major protein component of the flagellar membrane. Transmission electron microscopy shows a complete loss of the glycocalyx normally observed on the flagellar surface, suggesting it is composed of the ectodomains of FMG-1B molecules. Microsphere movements and gliding motility are also greatly reduced in the 5′-UTR mutant. Together, these data provide the first rigorous demonstration that FMG-1B is necessary for the normal expression of force at the flagellar surface in Chlamydomonas.
This article has an associated First Person interview with authors from the paper.
The impact of large-scale deployment of Wolbachia mosquitoes on arboviral disease incidence in Rio de Janeiro and Niterói, Brazil: study protocol for a controlled interrupted time series analysis using routine disease surveillance data
Authors: Durovni Betina , Saraceni Valeria , Eppinghaus Ana , Riback Thais I.S. , Moreira Luciano A. , Jewell Nicholas P. , Dufault Suzanne M. , O'Neill Scott L. , Simmons Cameron P. , Tanamas Stephanie K. , Anders Katherine L. 
Published: August 2019

Background: Rio de Janeiro and Niterói municipalities in southeastern Brazil experience large dengue epidemics every 2 to 5 years, with >100,000 cases notified in epidemic years. Costs of vector control and direct and indirect costs due to the Aedes-borne diseases dengue, chikungunya and Zika were estimated to total $650 million USD in 2016, but traditional vector control strategies have not been effective in preventing arboviral disease outbreaks. The Wolbachia method is a novel and self-sustaining approach for the biological control of arboviral diseases, in which the transmission potential of Ae. aegypti mosquitoes is reduced by stably transfecting them with the Wolbachia bacterium. This paper describes a study protocol for evaluating the effect of large-scale non-randomised releases of Wolbachia mosquitoes on the incidence of dengue, Zika and chikungunya in the municipalities of Niterói and Rio de Janeiro. This follows a lead-in period since 2014 involving intensive community engagement, regulatory and public approval, entomological surveys, and small-scale pilot releases. Method: The planned releases during 2017-2019 cover a combined area of 121 km2 with a resident population of 1.1 million, across the two cities. Untreated areas with comparable historical dengue profiles and sociodemographic characteristics have been identified a priori as comparative control areas in each municipality. The proposed pragmatic epidemiological approach combines a controlled interrupted time series analysis of routinely notified suspected and laboratory-confirmed arboviral cases, together with monitoring of arbovirus activity utilising outbreak signals routinely used in public health disease surveillance. Discussion: If the current project is successful, this model for control of arboviral disease through Wolbachia releases can be expanded nationally and regionally.
Manufacturers’ Competition and Cooperation in Sustainability: Stable Recycling Alliances
Authors: Tian Fang , Sošić Greys , Debo Laurens 
Published: August 2019

Rather than organizing disposal of consumer-generated waste themselves, many states and countries have passed legislation that makes producers responsible for the proper disposal (i.e., recycling) of the products that they bring to the market. We study the stability of producers’ strategies emerging under such legislation. In our paper, the producers compete with multiple differentiated products in consumer markets but may consider cooperating when recycling those products to benefit from economies of scale. Products made by different producers or sold in different markets might still be considered for joint recycling. Our main questions are when and whether firm-based recycling strategies (i.e., separately recycling products falling under same brand) or market-based recycling strategies (i.e., separately recycling products falling in the same product category) emerge as stable outcomes. To that end, we analyze a series of simple producer-market configurations. We first look at an asymmetric market model with two producers making three products in two markets, and then, we look at a symmetric market model with two producers competing with four products in two markets. Our results show that, with intense market competition and differentiated market sizes, producers may recycle their products on their own without cooperating with others. In some instances, they can add a product from their competitor to their recycling mix. Because these outcomes are never socially optimal, they may reduce social welfare and require government intervention. Otherwise, with less intense competition or more equitable market shares, all-inclusive (market-based) recycling is the most common stable outcome with high (low) scale economies, and the firms’ independent choices might lead to social optima.This paper was accepted by Serguei Netessine, operations management.
Dynamic Learning and Pricing with Model Misspecification
Authors: Nambiar Mila , Simchi-Levi David , Wang He 
Published: August 2019

We study a multiperiod dynamic pricing problem with contextual information, where the seller uses a misspecified demand model. The seller sequentially observes past demand, updates model parameters, and then chooses the price for the next period based on time-varying features. We show that model misspecification leads to a correlation between price and prediction error of demand per period, which, in turn, leads to inconsistent price elasticity estimates and hence suboptimal pricing decisions. We propose a “random price shock” (RPS) algorithm that dynamically generates randomized price shocks to estimate price elasticity, while maximizing revenue. We show that the RPS algorithm has strong theoretical performance guarantees, that it is robust to model misspecification, and that it can be adapted to a number of business settings, including (1) when the feasible price set is a price ladder and (2) when the contextual information is not IID. We also perform offline simulations to gauge the performance of RPS on a large fashion retail data set and find that is expected to earn 8%–20% more revenue on average than competing algorithms that do not account for price endogeneity. This paper was accepted by Serguei Netessine, operations management.
Supply Disruptions and Optimal Network Structures
Authors: Bimpikis Kostas , Candogan Ozan , Ehsani Shayan 
Published: August 2019

This paper studies multitier supply chain networks in the presence of disruption risk. Firms decide how much to source from their upstream suppliers so as to maximize their expected profits, and prices of intermediate goods are set so that markets clear. We provide an explicit characterization of (expected) equilibrium profits, which allows us to derive insights into how the network structure—that is, the number of firms in each tier, production costs, and disruption risk—affect firms’ profits. Furthermore, we establish that networks that maximize profits for firms that operate in different stages of the production process—that is, for upstream suppliers and downstream retailers—are structurally different. In particular, the latter have relatively less diversified downstream tiers and generate more variable output than the former. Finally, we consider supply chains that are formed endogenously. Specifically, we study a setting where firms decide whether to engage in production by considering their (expected) postentry profits. We argue that endogenous entry may lead to chains that are inefficient in terms of the number of firms that engage in production. This paper was accepted by Vishal Gaur, operations management.
Reducing Discrimination with Reviews in the Sharing Economy: Evidence from Field Experiments on Airbnb
Authors: Cui Ruomeng , Li Jun , Zhang Dennis J. 
Published: August 2019

Recent research has found widespread discrimination by hosts against guests of certain races in online marketplaces. In this paper, we explore ways to reduce such discrimination using online reputation systems. We conducted four randomized field experiments among 1,801 hosts on Airbnb by creating fictitious guest accounts and sending accommodation requests to them. We find that requests from guests with African American–sounding names are 19.2 percentage points less likely to be accepted than those with white-sounding names. However, a positive review posted on a guest’s page significantly reduces discrimination: when guest accounts receive a positive review, the acceptance rates of guest accounts with white- and African American–sounding names are statistically indistinguishable. We further show that a nonpositive review and a blank review without any content can also help attenuate discrimination, but self-claimed information on tidiness and friendliness cannot reduce discrimination, which indicates the importance of encouraging credible peer-generated reviews. Our results offer direct and clear guidance for sharing-economy platforms to reduce discrimination. This paper was accepted by Vishal Gaur, operations management.
Design of Linear Block Code Encoder and Decoder Using Electro-optical and All-optical Units
Authors: Srivastava Vivek Kumar , Pal Amrindra , Sharma Sandeep 
Published: August 2019

Abstract
In this paper novel designs for linear block code encoder and decoder using optical techniques have been proposed. The structures are designed and simulated using lithium niobate based Mach–Zehnder Interferometer (LN-MZI) and nonlinear material MEH-PPV [poly (2-methoxy-5-(28-ethylhexyloxy)-PPV)] (plasmonic) based MZI (P-MZI). The proposed LN-MZI designs offer attractive parameters such as high extinction ratio (>35 dB) and low insertion loss (<0.095 dB), while the proposed P-MZI designs possess a compact structure (3,020–12,375 µm2). An analytical comparison between the two design methodologies and other earlier proposed designs is presented. Each design is presented with a verified mathematical structure. Other performance parameters like contrast ratio and amplitude modulation have also been computed for the presented designs.
Discovery of ST1 centers in natural diamond
Authors: Balasubramanian Priyadharshini , Metsch Mathias H. , Reddy Prithvi , Rogers Lachlan J. , Manson Neil B. , Doherty Marcus W. , Jelezko Fedor 
Published: August 2019

Abstract
The ST1 center is a point defect in diamond with bright fluorescence and a mechanism for optical spin initialization and readout. The center has impressive potential for applications in diamond quantum computing as a quantum bus to a register of nuclear spins. This is because it has an exceptionally high readout contrast, and unlike the well-known nitrogen-vacancy center, it does not have a ground state electronic spin that decoheres the nuclear spins. However, its chemical structure is unknown, and there are large gaps in our understanding of its properties. We present the discovery of ST1 centers in natural diamond. Our experiments identify interesting power dependence of the center’s optical dynamics and reveal new electronic structure. We also present a theory of its electron-phonon interactions, which we combine with previous experiments, to shortlist likely candidates for its chemical structure.
Archaeoacoustic Research of Ljubostinja and Naupara Medieval Monastic Churches
Authors: Đorđević Zorana , Novković Dragan 
Published: August 2019

Abstract
The overall experience of religious practice is significantly affected by the acoustical properties of temples. Divine service is the most important act in the Orthodox Church, which equally demands intelligibility of speech for preaching and as well as adequate acoustics for Byzantine chanting as a form of a song-prayer. In order to better understand and contribute to unlocking the role of sound in these historical sacral spaces, this paper explores the acoustics of two well-preserved Orthodox churches, from Ljubostinja and Naupara monastery, built in the last building period of medieval Serbia (1371–1459). These represent two types of the Morava architectural style – triconch combined with a developed and compressed inscribed cross, respectively. Using EASERA software, we measured the impulse response for two sound source positions – in the altar and in the southern chanting apse, as the main points from which the Orthodox service is carried out. Thus obtained acoustic parameters (RT, EDT, C50 and STI) were further analysed, pointing out the differences in experiencing sound between naos and narthex, as well as how the position of the sound source influenced the experience of sound. Finally, we compared the results with previous archaeoacoustic research of the churches from the same building period.
Differential Involvement of Three Brain Regions during Mouse Skill Learning
Authors: Weible Aldis P. , Posner Michael I. , Niell Cristopher M. 
Published: August 2019

AbstractHuman skill learning is marked by a gradual decrease in reaction time (RT) and errors as the skill is acquired. To better understand the influence of brain areas thought to be involved in skill learning, we trained mice to associate visual-spatial cues with specific motor behaviors for a water reward. Task acquisition occurred over weeks and performance approximated a power function as often found with human skill learning. Using optogenetics we suppressed the primary visual cortex (V1), anterior cingulate cortex (ACC), or dorsal hippocampus (dHC) on 20% of trials at different stages of learning. Intermittent suppression of the V1 greatly reduced task performance on suppressed trials across multiple stages but did not change the overall rate of learning. In accord with some recent models of skill learning, ACC suppression produced higher error rates on suppressed trials throughout learning the skill, with effects intensifying in the later stages. This would suggest that cognitive influences mediated by the anterior cingulate continue throughout learning. Suppression of the hippocampus only modestly affected performance, with largely similar effects seen across stages. These results indicate different degrees of V1, ACC, and dHC involvement in acquisition and performance of this visual-spatial task and that the structures operate in parallel, and not in series, across learning stages.