bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giant intercostal nerve schwannoma in a patient with neurofibromatosis type 2
Authors: Ampollini Luca , Ventura Luigi , Gnetti Letizia , Carbognani Paolo , Silini Enrico Maria , Rusca Michele 
Published: July 2018

Purpose: To describe a case of giant intercostal nerve schwannoma successfully resected in a patient with neurofibromatosis type 2. Methods: A 44-year-old woman, with a history of neurofibromatosis type 2, presented with chest discomfort and mild dyspnea. She had undergone a recent resection of a large frontal parasagittal benign meningioma. Radiologic examinations showed a large lesion (9×12×9 cm) of the left hemithorax causing a complete atelectasis of left upper lobe. Bronchoscopy did not show any endobronchial alterations, apart from an ab estriseco compression of the left upper bronchial tree. A transthoracic needle biopsy was then performed and microscopic examination revealed a mesenchymal tumor composed of spindle-like cells. Results: A video-assisted thoracoscopic surgery procedure was proposed. The tumor mass appeared to be tenaciously adherent to the parietal pleura in its anterolateral aspect, confirming the radiologic appearance. No invasion of the lung parenchyma or parietal pleural metastases were visible. Therefore, a left posterolateral thoracotomy at the fifth intercostal space was performed and a macroscopic complete resection was carried out. The recovery was uneventful and the patient was discharged on postoperative day 5. The histologic examination revealed a moderate cellular proliferation of spindle-shaped and oval to polygonal cells with frequent Verocay bodies; mitotic figures were rare. The tumor cells were strongly S-100 positive. The microscopic features were consistent with benign intercostal schwannoma. Eight years later, the patient is disease-free and asymptomatic. Conclusions: An unusual case of giant intercostal nerve schwannoma successfully resected in a patient with neurofibromatosis type 2 is described.
A hospital-based study of socioeconomic status and clinical spectrum of rheumatic heart disease patients of Assam, North-East India
Authors: Baro Lokajeet , Sharma Neha , Toor Devinder , Chaliha Mriganka S , Kusre Giriraj , Baruah Sreemanta M , Das Sangeeta 
Published: July 2018

Objective The aim of this study was to assess the impact of socioeconomic factors in increased prevalence of rheumatic heart disease and its clinical spectrum in Assam, North-East India. Method A case–control questionnaire-based study of 100 echocardiography confirmed rheumatic heart disease cases with age- and sex-matched healthy controls from Assam medical college and hospital in Dibrugarh, Assam was conducted. Results There was a trend toward increased risk of rheumatic heart disease and its clinical spectrum with respect to low socioeconomic status. Three parameters were found to be statistically significant in posing increased risk towards rheumatic heart disease: rural dwelling location ( p < 0.0001, odds ratio (OR) 4.1, 95% confidence interval (CI = 2.29−7.45), low monthly income ( p < 0.001, OR=9.5, 95% CI = 4.99−18.1) and education status ( p < 0.05, OR=9.5, 95% CI = 1.866). Out of the severe cases of mitral stenosis, mitral regurgitation and aortic regurgitation, 69.6%, 58.3% and 34% patients were of low socioeconomic status. Conclusion Socioeconomic factors can be of significant importance in increased prevalence of rheumatic heart disease and might also influence the clinical spectrum of the disease. Increased awareness and up-gradation of socioeconomic status might ameliorate the prevalence of rheumatic heart disease.
Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma
Authors: Rubenstein James L. , Geng Huimin , Fraser Eleanor J. , Formaker Paul , Chen Lingjing , Sharma Jigyasa , Killea Phoebe , Choi Kaylee , Ventura Jenny , Kurhanewicz John , Lowell Clifford , Hwang Jimmy , Treseler Patrick , Sneed Penny K. , Li Jing , Wang Xiaomin , Chen Nianhang , Gangoiti Jon , Munster Pamela N. , Damato Bertil 
Published: July 2018

Key PointsLenalidomide penetrates ventricular CSF and is active as monotherapy in relapsed CNS lymphomas. Maintenance lenalidomide is feasible and may potentiate response duration after salvage in relapsed PCNSL and delay WBRT.
Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models
Authors: Rivera-Munoz Paola , Laurent Anouchka P. , Siret Aurelie , Lopez Cecile K. , Ignacimouttou Cathy , Cornejo Melanie G. , Bawa Olivia , Rameau Philippe , Bernard Olivier A. , Dessen Philippe , Gilliland Gary D. , Mercher Thomas , Malinge Sébastien 
Published: July 2018

Key PointsJak3A572V-induced CTCL-like disorders are mutant Jak3 dose-dependent, transplantable, and phenotypically heterogeneous. Trisomy 21, somatically acquired in human CTCL, functionally cooperates with activated Jak3 to enhance the CTCL-like phenotype in vivo.
Impact of post-ASCT maintenance therapy on outcomes in patients with newly diagnosed multiple myeloma in Connect MM
Authors: Jagannath Sundar , Abonour Rafat , Durie Brian G. M. , Narang Mohit , Terebelo Howard R. , Gasparetto Cristina J. , Toomey Kathleen , Hardin James W. , Wagner Lynne , Agarwal Amit , Srinivasan Shankar , Kitali Amani , Flick E. Dawn , Sturniolo Michael , Rifkin Robert M. 
Published: July 2018

Abstract
Autologous stem cell transplantation (ASCT) followed by lenalidomide maintenance therapy is the standard of care for transplant-eligible patients with newly diagnosed multiple myeloma (NDMM). Clinical trials show progression-free survival (PFS) benefits, with some studies (Cancer and Leukemia Group [CALGB] trial and meta-analysis) also showing overall survival (OS) benefits, but applicability to real-world clinical settings is unclear. Using data from Connect MM, the largest US-based observational registry of NDMM patients, we analyzed effects of maintenance therapy on long-term outcomes in 1450 treated patients enrolled from 2009 to 2011. Patients who received induction therapy and ASCT (n = 432) were analyzed from 100 days post-ASCT (data cut 7 January 2016): 267 received maintenance (80% lenalidomide-based [of whom 88% received lenalidomide monotherapy]); 165 did not. Lenalidomide maintenance improved median PFS and 3-year PFS rate vs no maintenance (50.3 vs 30.8 months [hazard ratio (HR), 0.62; 95% confidence interval (CI), 0.46-0.82; P &lt; .001] and 56% vs 42%, respectively). Improvements in median OS and 3-year OS rate were associated with lenalidomide maintenance vs no maintenance (not reached in either group [HR, 0.54; 95% CI, 0.36-0.83; P = .005] and 85% vs 70%, respectively). Five hematologic serious adverse events were reported with lenalidomide maintenance (pancytopenia [n = 2], febrile neutropenia, anemia, and thrombocytopenia [n = 1 each]) and 1 with no maintenance (thrombocytopenia). Second primary malignancies occurred at rates of 1.38 and 2.19 events per patient-year in lenalidomide maintenance and no maintenance groups, respectively. Survival benefits associated with lenalidomide maintenance previously demonstrated in clinical trials were observed in this community-based Connect MM Registry.
Contemporary Radiation Treatment of Prostate Cancer in Africa: A Ghanaian Experience
Authors: Asamoah Francis A. , Yarney Joel , Awasthi Shivanshu , Vanderpuye Verna , Venkat Puja S. , Fink Angelina K. , Naghavi Arash O. , Abrahams Afua , Mensah James E. , Sasu Evans , Tagoe Samuel N.A. , Johnstone Peter A.S. , Yamoah Kosj 
Published: July 2018

Purpose Data on prostate cancer (PCa) treatment in Africa remains under-reported. We present a review of the management of PCa at the cancer center of the largest tertiary referral facility in Ghana, with emphasis on curative treatment. Methods We retrospectively reviewed data on 1,074 patients seen at the National Center for Radiotherapy and Nuclear Medicine from 2003 to 2016. Patient and disease characteristics at presentation are presented using descriptive statistics. The χ2 and Fisher’s exact tests and Mann-Whitney U test were used to analyze differences between categorical and continuous variables, respectively. Methods of survival analysis were used to evaluate the relative risk of biochemical disease-free survival (bDFS). Results Seventy percent of the study population presented with localized disease. High-risk disease presentation accounted for 64.4% of these patients. Only 57.6% of patients with localized disease received curative radiotherapy. The 5-year overall survival for the curative cohort was 96% (interquartile range, 93% to 98%). The 5-year bDFS rates for low-, intermediate-, and high-risk groups were 95%, 70%, and 48%, respectively. Both Gleason score and pretreatment prostate-specific antigen were significant predictors for bDFS in multivariable analysis. Conclusion We show that the majority of patients with PCa have locally advanced disease at the time of presentation for radiotherapy. bDFS was significantly better for low- and intermediate-risk than for high-risk disease. These data emphasize the dire need to re-evaluate screening and patient education of PCa in regions of the world with high incidence and mortality as well as the need for improved access to care and treatment delivery.
Phase 2 Open-Label Trial Investigating Percutaneous Laser Ablation for Treatment of Early-Stage Breast Cancer: MRI, Pathology, and Outcome Correlations
Authors: Schwartzberg Barbara , Lewin John , Abdelatif Osama , Bernard Jacqueline , Bu-Ali Hanadi , Cawthorn Simon , Chen-Seetoo Margaret , Feldman Sheldon , Govindarajulu Sasirekha , Jones Lyn , Juette Arne , Kavia Sanjay , Maganini Robert , Pain Simon , Shere Mike , Shriver Craig , Smith Simon , Valencia Alexandra , Whitacre Eric , Whitney Roger 
Published: July 2018

Abstract

Background
An institutional review board-approved, multicenter clinical trial was designed to determine the efficacy and outcome of percutaneous laser ablation (PLA) in the treatment of invasive ductal breast carcinoma (IDC). Post-ablation magnetic resonance imaging (MRI) was compared with surgical pathology in evaluation of residual post-ablation IDC and ductal carcinoma in situ.

Methods
Patients with a single focus of IDC 20 mm or smaller by pre-ablation MRI were treated with PLA. The patients underwent a 28-day post-ablation MRI, followed by surgical resection. Cell viability criteria were applied to pre- and post-ablation pathology specimens, which evaluated hematoxylin–eosin (H&E), cytokeratin (CK) 8/18, estrogen receptor, and Ki67 staining patterns.

Results
In this study, 61 patients were reported as the intention-to-treat cohort for determination of PLA efficacy. Of these 61 patients, 51 (84%) had complete tumor ablation confirmed by pathology analysis. One subject’s MRI imaging was not performed per protocol, which left 60 subjects evaluable for MRI pathology correlation. Five patients (8.3%) had residual IDC shown by both MRI and pathology. Post-ablation discordance was noted between MRI and pathology, with four patients (6.7%) false-positive and four patients (6.7%) false-negative. The negative predictive value (NPV) of MRI for all the patients was 92.2% (95% confidence interval [CI], 71.9–91.9%). Of the 47 patients (97.9%) with tumors 15 mm or smaller, 46 were completely ablated, with an MRI NPV of 97.7% (95% CI, 86.2–99.9%).

Conclusions
Percutaneous laser ablation is a potential alternative to surgery for treatment of early-stage IDC. Strong correlations exist between post-ablation MRI and pathologic alterations in CK8/18, ER, and Ki67 staining.
Typification of names of plants described by Carlos Pau from Morocco (1908–1922)
Authors: Nualart Neus , Ibáñez Neus , Susanna Alfonso , Soriano Ignasi 
Published: July 2018

AbstractThe vascular plant names proposed by Carlos Pau from Morocco between 1908 and 1922 were studied and, when necessary and possible, typified. Nine lectotypes for Pau names plus one for a synonym have been designated; most of them preserved in MA and BC herbaria (isolectotypes at BCN, G, LD, and P).
A worldwide phylogeny of Adiantum (Pteridaceae) reveals remarkable convergent evolution in leaf blade architecture
Authors: Huiet Layne , Li Fay-Wei , Kao Tzu-Tong , Prado Jefferson , Smith Alan R. , Schuettpelz Eric , Pryeri Kathleen M. 
Published: July 2018

AbstractAdiantum is among the most distinctive and easily recognized leptosporangiate fern genera. Despite encompassing an astonishing range of leaf complexity, all species of Adiantum share a unique character state not observed in other ferns: sporangia borne directly on the reflexed leaf margin or “false indusium” (pseudoindusium). The over 200 species of Adiantum span six continents and are nearly all terrestrial. Here, we present one of the most comprehensive phylogenies for any large (200+ spp.) monophyletic, subcosmopolitan genus of ferns to date. We build upon previous datasets, providing new data from four plastid markers (rbcL, atpA, rpoA, chlN) for 146 taxa. All sampled taxa can be unequivocally assigned to one of nine robustly supported clades. Although some of these unite to form larger, well­supported lineages, the backbone of our phylogeny has several short branches and generally weak support, making it difficult to accurately assess deep relationships. Our maximum likelihood­based ancestral character state reconstructions of leaf blade architecture reveal remarkable convergent evolution across multiple clades for nearly all leaf forms. A single unique synapomorphy—leaves once­pinnate, usually with prolonged rooting tips—defines the philippense clade. Although a rare occurrence in Adiantum, simple leaves occur in three distinct clades (davidii, philippense, peruvianum). Most taxa have leaves that are more than once­pinnate, and only a few of these (in the formosum and pedatum clades) exhibit the distinct pseudopedate form. Distributional ranges for each of the terminal taxa show that most species (75%) are restricted to only one of six major biogeographical regions. Forty­eight of our sampled species (nearly one­third) are endemic to South America.
Unravelling Vellozo’s Dupatya (Eriocaulaceae): A long­standing case of mistaken identities and species
Authors: Chagas Earl C. de O. , Trovó Marcelo , Zappi Daniela C. , Prado Jefferson , Giulietti Ana M. 
Published: July 2018

AbstractA re­evaluation of the Dupatya (Eriocaulaceae) names proposed by Vellozo in the Florae fluminensis is presented. Based on analyses of Vellozo’s text, plates, original material and protologues of all species of Eriocaulon and Paepalanthus originally assigned to Dupatya, we accept E. ligulatum and P. aequalis, while D. hirsuta is reduced into synonymy with E. kunthii. Lectotypes are proposed for names based on the original plates of Vellozo’s work deposited at the Manuscript Section of the Rio de Janeiro National Library.
Reconstrucción del proceso de elaboración de la Ley Orgánica Constitucional de Enseñanza: actores, proyectos y disputas ideológicas. Chile, 1973–1990
Authors: Pérez Navarro Camila 
Published: July 2018

The aim of this article is to analyze the main debates, projects and conflicts presented in the process of drafting the Constitutional Organic Law of Education (LOCE) during the period of the Chilean Dictatorship (1973-1990). In that period, the national education system was the subjected to structural transformation, as market principles were introduced to schools and higher education institutions in response to decisions made by various civilian and military players. This research reports an analysis of their proposals and lines of action, and how they were involved in the discussion framework in which the LOCE was drawn up. The research is based on an examination of the education-related records made during meetings of the Military Junta, the Commission for the Study of the New Political Constitution of the Republic of Chile, the Council of State, the Commission for the Study of Constitutional Organic Laws, and the Commissions for the Constitutional Organic Law on Education. The sources analyzed show that in the process of drafting the normative framework of the Chilean educational system that was to remain in force until 2009, two conflicting political ideologies were at play: on the one hand, the maintenance of a discourse of «Minimum Teaching State» (defended by traditional politicians and members of the Armed Forces) and, on the other hand, the neoliberal project.
Interview with Heinz-Elmar Tenorth
Authors: Augschöll Blasbichler Annemarie , Vogt Michaela 
Published: July 2018

Professor Heinz-Elmar Tenorth till 2011 was Professor for the History of Education at Humboldt-University in Berlin. Before he studied and did his PhD at the University of Würzburg. After he stayed in the same institution for some years as research assistant before becaming professor in the educational area, first in Frankfurt a. M. and then till his retirement in Berlin. As researcher he is very well known in his field and he was also the head of several large projects funded by the DfG and other foundations. Additionally, many of his publications are well known amongst researchers in the field of educational research. The topics he published about are broad and cover theoretical reflections in the field of education and especially history of education as well as research results. Of special interest has always been the idea of «Bildung» for him, for example combined with reflections about political influence, institutional structures or the ideas of «Bildsamkeit» and «Grundlegende Bildung». Also professionalism of teachers and researchers in the field of education are further topics he worked on and is still working on. Luckily he is still very active as researcher and enriches the field of education with reflexive and innovative approaches in different ways. Reading his publications is as refreshing as it is informative and in some ways, it represents a challenge in the most positive sense of the term.
Xyloglucan adsorption for measuring the specific surface area on various never-dried cellulose nanofibers
Authors: Moser Carl , Backlund Hanéle , Drenth Louise , Henriksson Gunnar , Lindström Mikael E. 
Published: July 2018

Abstract
In this paper, we explore xyloglucan adsorption to cellulose nanofibers as a method for the evaluation of their quality (i. e., the degree of disintegration) and the accessible surface area in the wet state and at low ionic strength. This method was shown to be capable of estimating the surface areas of 14 different cellulose nanofiber qualities from both hardwood and softwood with different pretreatments, including enzymatic hydrolysis using a monocomponent endoglucanase, TEMPO-mediated oxidation, and carboxymethylation. The cellulose surface measured using this method showed a correlation with the degree of disintegration expressed as transmittance for different concentrations of xyloglucan.
Impacts du maintien du français comme langue d’enseignement sur la mise en œuvre de l’approche par les compétences : cas de la Côte d’Ivoire
Authors: KOUASSI Konan Stanislas 
Published: July 2018

RÉSUMÉ. Dans le but d’améliorer la qualité de l’éducation et accroître la performance de son système éducatif, la Côte d’Ivoire a adopté l’Approche par les compétences, une démarche éducative fait de l’apprenant le principal acteur de ses apprentissages et qui demande donc qu’il prenne une part active dans la construction du savoir. Pourtant, le français est resté l’unique langue d’enseignement dans ce pays à forte hétérogénéité linguistique où tous les apprenants n’en développent une compétence suffisante à communiquer langagièrement. Cette étude qui vise à rendre compte des impacts du maintien du français dans ce rôle sur la mise en œuvre de l’Approche Par les Compétences à partir de données collectées au terme d’une enquête conduite auprès de 147 et d’observations de classe a révélé que tous les apprenants ne parviennent pas à prendre une part active dans la construction du savoir alors que ceux-ci sont supposés être les principaux acteurs de leurs apprentissages tout simplement parce qu’ils ne développent pas tous une compétence suffisante à communiquer langagièrement en français, la langue d’enseignement. Mots clés : Approche par compétence, Côte d’Ivoire, français, interactions verbales, langueABSTRACT. In order to improve the quality of education and increase the performance of its education system, Côte d'Ivoire has adopted the Skills Approach, an educational approach that makes the learner the main player in its learning and which therefore demands that he take an active part in the construction of knowledge. However, French has remained the only language of instruction in this country with a high degree of linguistic heterogeneity where all learners develop a sufficient competence to communicate linguistically. This study aims to report on the impacts of the maintenance of French in this role on the implementation of the Competency-Based Approach based on data collected at the end of a survey conducted at 147 and class observations. revealed that not all learners are able to take an active part in the construction of knowledge when they are supposed to be the main actors in their learning simply because they do not all develop sufficient competence to communicate linguistically in French, the language of instruction. Keywords: Approach by skill, French, Ivory Coast, language, verbal interactions
L’écriture de soi chez Malika Mokeddem : libération ou engagement ?
Authors: BEZZOUH Djedjigua , RAMDANE Souhila 
Published: July 2018

RÉSUMÉ Le présent travail étudie l’écriture de soi dans les deux œuvres de Malika Mokeddem : Mes hommes et je dois tout à ton oubli. Il s’agit particulièrement d’interroger le projet autobiographique dans Mes hommes et la coïncidence du réel et du fictionnel dans Je dois tout à ton oubli, afin d’appréhender la connexité tissée dans ces deux romans. Notre étude est étayée par deux concepts théoriques de l’écriture de soi à savoir : l’autobiographe et l’autofiction. Sur le plan méthodologique, il sera question d’examiner plusieurs éléments qui font basculer le récit entre référentialité et fictionnalité. Lesquels éléments sont, d’une part, d’ordre narratif, ils révèlent la stratégie d’écriture chez M. Mokeddem. D’autre part, d’ordre thématique qui couvrent les objectifs de l’écriture de soi. Conséquemment, l’écriture de soi chez M. Mokeddem puise sa particularité à la fois des procédés usités et du réseau de significations qui relie les deux romans. Mots- clés : autobiographie, autofiction, énonciation, thèmes et objectifs, indices paratextuels. ABSTRACT. This research paper attempts to expose self writing in thetwo works of Malika Mokeddem My Men and I Owe Everything to Your forgetfulness . This study is particularly about questioning the autobiographical project in My Men and the fact and the fictional in I Owe Everything to Your forgetfulness and that to comprehend the connectedness woven in these two novels. Our study will be grounded on two theoritical concepts of self writing: the autobiography and the autofiction. From a methodological point of view, it will be a question of examining several elements that swing texts between referentiality and functionality. These elements are on one hand narrative; they reveal the writing strategy of M Mokeddem. On the other hand, that of the thematic order which covers the objectives of self writing. Consequently, Mokeddem 's self writing draws its particularity from both the commonly used processes and the network of meanings which link the two novels. Keywords: autobiography, autofiction, enunciation, themes and objectives, Paratextual indices