bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary manifestations of juvenile vs. adult systemic sclerosis: insights into pathophysiological and clinical features
Authors: Di Pasquale Gabriele , Caione Nicholas , Di Berardino Alessio , Di Donato Giulio 
Published: November 2024

AbstractJuvenile systemic sclerosis (jSSc), the pediatric counterpart of systemic sclerosis (SSc), is a rare autoimmune disorder characterized by vasculopathy and fibrotic disorders. It ranks among the rheumatologic diseases with the highest rates of morbidity and mortality, predominantly impacting females. Although a universally accepted classification for jSSc remains elusive, a provisional classification proposed in 2007 integrates major and minor criteria, reflecting the involvement of diverse organs and tissues. Pulmonary manifestations are relatively common in jSSc, occurring in 36% to 55% of cases. Particularly lung complications include children s interstitial lung disease (chILD), pulmonary arterial hypertension (PAH) and nodules. The aim of this paper is to describe the main pulmonary manifestations of patients with jSSc in relation to SSc, highlighting fundamental pathophysiological, and clinical features based on the latest literature data.
Reliability, Concurrent Validity, Responsiveness and Measurement Error of the Portuguese Version of Comprehensive Motor Coordination Scale in Individuals With Parkinson's Disease
Authors: Rocha Clara Rezende , Osawa Caroline Rodrigues , Henrique Maria Eduarda Salum Aveiro , de Andrade Pedro Henrique Sousa , de Souza Luciane Aparecida Pascucci Sande , Luvizutto Gustavo José 
Published: November 2024

ABSTRACTIntroductionAssessment of motor coordination in patients with Parkinson's disease (PD) is based on motor performance and does not consider movement quality.ObjectiveTo validate the Comprehensive Coordination Scale (CCS) in patients with PD and correlate it with motor impairment.MethodsThis cross‐sectional and case‐control study included 15 individuals with PD and 15 healthy older individuals as controls. Motor impairments were measured using the MDS‐UPDRS (Part III). Motor coordination (CCS) was evaluated by five examiners and classified into four domains: upper and lower limbs and unilateral and bilateral tasks. CCS scores were compared between the groups using the Mann–Whitney test; concurrent validity was evaluated using Spearman's correlation between CCS and PD scales; and the inter‐rate reliability was calculated by intraclass correlation coefficient (ICC).ResultsThere was significant difference between the groups in the upper limb (p < 0.001), lower limb (p = 0.006), unilateral (p < 0.001), bilateral (p = 0.015), and total (p < 0.001) CCS scores. Total CCS score (ICC 0.78), upper limb (ICC 0.71), lower limb (ICC 0.86) and unilateral (ICC 0.74) showed high inter‐rate reliability. Bilateral domain (ICC 0.92) showed very high inter‐rate reliability. And, there was negative correlation between CCS upper limb and postural tremor of hands (r = −0.716; p = 0.008), unilateral CCS domain with postural tremor of hands (r = −0.687; p = 0.012), and CCS total score with postural tremor of hands (r = −0.804; p = 0.002).ConclusionThere was high inter‐rater agreement for all CCS items, mainly in the lower limb and bilateral tasks. And, there was a moderate‐to‐very strong correlation between the total and sub‐items of the CCS and motor impairment.
Salivary effector DcE1 suppresses plant defense and facilitates the successful feeding of Asian citrus psyllid, Diaphorina citri
Authors: Kuang Yinhui , Shangguan Chaozhi , Wang Chuyang , Gao Liwei , Yu Xiudao 
Published: November 2024

AbstractBACKGROUNDPiercing‐sucking insects secrete diverse repertoires of effectors into their hosts to weaken host defenses and promote infestation. The Asian citrus psyllid, Diaphorina citri Kuwayama, is the most destructive insect pest in citrus orchards because of its role as a vector for the huanglongbing pathogen, Candidatus Liberibacter asiaticus (CLas). However, specific effector proteins and their functions in D. citri remain unclear.RESULTSWe demonstrate that DcE1, a salivary protein gene from D. citri, is predominantly expressed in the salivary gland tissues and is delivered into host plants during feeding. Transient expression in tobacco leaves revealed that DcE1 was subcellularly localized in the cytoplasm and plasma membrane, where it inhibited BAX‐ and INF1‐induced cell death, suppressed callose deposition, and activated the salicylic acid pathway by upregulating the expression of endo‐β‐1,3‐glucanase NtBGL2 and regulatory protein NtNPR1. Further, DcE1 knockdown by double‐stranded RNA (dsRNA) injection decreased the survival rates of D. citri and interrupted D. citri phloem‐feeding on host plants.CONCLUSIONThese results indicate that DcE1 is a novel effector that promotes plant susceptibility and enables D. citri feeding. These findings enhance our understanding of D. citri–plant interactions and offer a potential new target gene for the development of citrus protection strategies. © 2024 Society of Chemical Industry.
The Interaction Between Fluorinated Additives and Imidazolyl Ionic Liquid Electrolytes in Lithium Metal Batteries: A First‐Principles Study
Authors: Sun Rongde , Tang Jiaxin , Zhou Nan , Li Chengren , Yang Baifeng , Chen Zhigao , Lu Xiaohan , Luo Tingyu , Chang Zhen , Peng Changjun , Liu Honglai , Zhang Shaoze 
Published: November 2024

ABSTRACTThis investigation employs first‐principles calculations to explore the interaction between imidazolium ionic liquids (ILs) and fluoride additives on lithium metal surface. Our focus lies in the comprehensive analysis of three distinct categories of fluorinated additives, each differing in their degree of fluorination. The computations reveal that fluorination plays a significant role in determining both the ionic conductivity and the formation of the solid–electrolyte interphase (SEI) film. Specifically, heightened fluorination enhances the oxidative stability of the system but diminishes the strength of solvent binding, resulting in the formation of larger salt/anion clusters and a decrease in ionic conductivity. Conversely, increased fluorination facilitates the interaction between fluorinated additives and the lithium metal surface, thereby aiding in the formation of a stable SEI film characterized by an abundance of inorganic LiF components. This is important as it serves to suppress dendrite growth and mitigate interface side reactions. Considering the combined influences of ionic conductivity and film formation, 1FP is suggested as the optimal candidate for pyridine‐based additive systems, with FEC preferred for cyclic ester‐based additive systems and BC for chain ester‐based additive systems. This study provides theoretical references for the design of ionic liquid‐fluorinated additive electrolyte systems that can protect the lithium metal anode.
Ternary MgAlFe‐Layered Double Hydroxide: Synthesis, Characterization, and Application in Photocatalytic Degradation
Authors: Cui Chenyuan , Zhang Liting , Xie Fujian , Zhu Chunmei , Yu Bo 
Published: November 2024

AbstractIn this study, MgAlFe‐layered double hydroxide (LDH) was prepared using the co‐precipitation method, and its performance as a photocatalyst for methylene blue (MB) degradation was evaluated. XRD and FTIR analyses confirmed the crystalline structure and successful incorporation of Al into the LDH layers. SEM and TEM images revealed a uniform morphology and layered structure and UV–vis DRS analysis showed that MgAlFe‐LDH has an appropriate band gap for visible light absorption. Photoluminescence studies indicated good charge separation, reducing electron‐hole recombination and enhancing photocatalytic performance. The effects of the Mg/Al/Fe molar ratio, illumination time, catalyst dosage, MB concentration, and pH on the degradation efficiency were examined. Optimized conditions of Mg/Al/Fe molar ratio 3:0.9:0.1, 180 min illumination, 10 mg L⁻¹ catalyst, 20 mg L⁻¹ MB, and pH 13 yielded a remarkable 90.4% MB degradation efficiency. The primary active species in the photocatalytic reaction were identified as hydroxyl radicals (·OH) and holes (h⁺). The incorporation of ternary LDH enhances the photocatalytic performance due to its high stability, versatility, and ability to integrate multiple metal cations. This study broadens the application of LDH in treating organic dye wastewater and provides new insights into the photocatalytic degradation of MB.
Exploring Reduction Techniques for Graphene Oxide: A Comparative Study of Thermal and Chemical Methods
Authors: Gnanasekaran Backiyalakshmi , Snekhalatha Umapathy 
Published: November 2024

AbstractGraphene oxide (GO) is a single layer of carbon atoms obtained from the oxidation of graphite by the modified Hummers' method. Sulfuric acid acts as an intercalating agent and allows potassium permanganate to enter the layers to oxidize each layer of graphite to form GO. The resultant GO is highly hydrophilic and less conductive in nature. We further reduced it using a combination of thermal and chemical methods. Thermally reduced GO has been produced by thermal treatment of GO, and chemically reduced GO was obtained by two different reducing agents, such as l‐ascorbic acid and sodium borohydride. The degree of oxidation and the purity of the RGO were analyzed using Fourier transform infrared (FTIR), Raman spectroscopy, X‐ray diffraction (XRD), and scanning electron microscopy (SEM). FTIR analysis of GO revealed distinct absorption peaks of oxygen‐based functional groups that show a higher degree of oxidation of the carbon structure. Upon reduction, the FTIR spectrum exhibits a partial or total removal of the same, which signifies the loss of oxygen and the partial restoration of the graphitic structure. The results emphasize that the carbon‐to‐oxygen ratio was higher in both reduction methods, but thermal reduction yielded a greater degree of deoxygenation than the other.
Improved Hemostatic Efficacy of Graviola‐Modified PVA–HA Hydrogels for Wound Healing: In Vitro and In Vivo Analysis
Authors: Shoair Abdel Ghany F. , Sahyon Heba A. , Shishtawy Mohammed A. El , Almalki Abdulraheem S.A. , Alqarni Ali Abdullah , Althobaiti Fayez , Shanab Mai M. A. H. , Khalaf Hussein A. 
Published: November 2024

AbstractThe formation of a hydrogel for wound dressing can be achieved through the combination of different materials having unique properties. Graviola fruit extract (GrE) not only imparts antimicrobial properties to the hydrogel but also contributes to the potential acceleration of wound healing due to its anti‐inflammatory and antioxidant properties. In this study, the freeze–thaw method was employed to create composite hydrogels consisting of polyvinyl alcohol, hyaluronic acid, cross‐linked with glutaraldehyde, and GrE. The study evaluated various properties of the gels, including swelling, porosity, gel fraction, and morphology. The obtained results indicated that the physicochemical characteristics of the hydrogels were affected by the level of GrE. The hydrogels had a significant capacity to absorb wound exudate, and their porous structure increased with GrE addition. Our results proved that different GrE‐based hydrogels (Gr1 and Gr2) treatments exhibited excellent hemolysis, hemostasis, antibacterial activity, and wound healing promotion. They also inhibited proinflammatory cytokines (IL‐6 and TNF‐α) and exhibited higher wound repair capacity. CD‐31 and collagen I increased significantly in wound tissues treated with Gr1 and Gr2 hydrogels. So, Gr1 and Gr2 hydrogels have demonstrated their potential as valuable local treatment and management for full‐thickness wounds.
Interfacial [S─Cu─C] Bonds Induced π‐d Electron Coupling Toward Modulating Charge Transfer for Efficient Solar Water Oxidation
Authors: Wang Cheng , Wang Kunpeng , Sun Shengdong , Wang Yuqiao , Wang Yongxiang , Li Shikuo 
Published: November 2024

AbstractRegulating the interfacial electric field to achieve rapid charge transfer is crucial for superior photoelectrochemical water splitting. Herein, the ultra‐thin hydrogen‐substituted graphdiyne (HsGDY) is precisely assembled on the surface of CdS nanorod array (Cu‐CdS‐HsGDY) by an in situ polymerization strategy. The strong π‐d electron coupling is aroused by the delocalized π electrons of HsGDY and the delocalized d electrons of CdS through the interfacial [S─Cu─C] bonds. The strong interfacial electric field can effectively promote the charge localization distribution and reduce the charge transfer resistance. The optimized Cu‐CdS‐HsGDY photoanode obtain a photocurrent density as high as 4.83 mA cm−2 at 1.23 V versus reversible hydrogen electrode in neutral electrolyte solution under AM 1.5G illumination, which is 6.8 times that of the pristine CdS. Moreover, the photoanode maintains an initial photocurrent density of 84% within 4 h without any assistance of sacrificial agents, which is a rather competitive performance of similar sulfide photoanodes. The mechanism of strong π‐d electron coupling on interfacial charge transfer and surface reaction kinetics is investigated by transient spectroscopy measurements, density functional theory calculation, and finite element simulation analysis. This work provides new insights into designing a reasonable interface structure to regulate charge transfer for achieve efficient PEC water splitting.
Regression Analysis of the Generalized Accelerated Hazards Models With Interval‐Censored Data Under Case‐Cohort Studies
Authors: Niu Haiyu , Sun Weipeng , Zhang Ximeng , Sun Jianguo 
Published: November 2024

ABSTRACTCase‐cohort studies are typically undertaken in scenarios where disease incidence is low, or data collection on certain variables is costly. Case‐cohort researches with interval‐censored data often rely on survival models like the proportional hazards models, proportional odds models, accelerated failure time models and so on. However, these standard assumptions might not always be suitable for survival outcomes modelling in practical scenarios. To address this limitation, we provide a more adaptable class of generalized accelerated hazards models for analysing interval‐censored failure times in case‐cohort studies, for which there appears to be no well‐established approach in the literature. We develop a sieve maximum likelihood estimation method where the unknown cumulative baseline hazard function is integrated with regression parameters. The proposed estimators are proven to be consistent and normally distributed. A simulation study is carried out to assess the empirical performance of the proposed methods and suggest their practical effectiveness. Finally, we illustrate the approach using a dataset from a study on Alzheimer's disease.
The influence of ‘biotics’ on the gut microbiome of dogs and cats
Authors: Wilson Sofia M , Swanson Kelly S 
Published: November 2024

ABSTRACTA global rise in pet ownership and an increasing tendency towards the humanisation of pets have resulted in a greater focus on improving animal health and longevity. These developments coincide with the increased recognition of the role of the gut microbiome in animal health. The gut microbiome has been shown to play a prominent role in gastrointestinal health, and it is becoming increasingly clear that these health benefits extend beyond the gut and into different physiological systems, such as the immune system. Dietary supplementation with products known as ‘biotics’, which include probiotics, prebiotics, synbiotics and postbiotics, is a strategy used to modify the gut microbiome and promote host health. Although biotics have been successfully used in companion animals, questions remain regarding appropriate biotic selection, mechanisms of action, optimum inclusion levels and safety. This review aims to summarise the effects of biotics on the gut microbiome of dogs and cats and assess their potential role in supporting gastrointestinal health.
Indocyanine green fluorescence imaging for lymph node detection and long‐term clinical outcomes in colorectal cancer surgery: A systematic review and meta‐analysis
Authors: Guo Hong , Luo Yun , Fu Zhaojun , Wang Dengchao 
Published: November 2024

AbstractBackgroundThe indocyanine green fluorescence imaging (ICG‐FI) technique is increasingly being used in laparoscopic colorectal surgery for lymph node mapping. However, there is no definitive standard regarding whether the application of this technique can significantly increase the detection rate of metastatic lymph nodes and improve long‐term prognosis.MethodsPubMed, Embase, Web of Science, and Cochrane Library databases were searched to include studies including ICG‐FI in laparoscopic colorectal surgery. Data on the detection rate of lymph nodes, metastatic rate of ICG‐positive nodes, and long‐term clinical outcomes were extracted following inclusion criteria.ResultsEighteen studies with a total of 1552 patients 922 with ICG‐guided laparoscopic and 630 without ICG technique were finally included. Clinical stage II/III colorectal tumors were the most commonly studies types. The patients using the ICG‐FI technique had more harvested lymph nodes (weighted mean: 23.5 vs. 18.9; WMD = 4.6; p < 0.00001) during dissection but a lower metastasis rate of ICG‐positive nodes (61/218 [28%] vs. 96/333 [28.9%]; OR = 1.45; p = 0.08). Compared with conventional laparoscopic colorectal surgery, additional ICG‐FI technique did not improve the 3 year overall survival rate (272/289 [94.1%] vs. 269/289 [93.1%]; OR = 1.19; p = 0.61), relapse‐free survival (246/289 [85.1%] vs. 249/289 [86.2%]; OR = 0.92; p = 0.72), and local recurrence rate (22/289 [7.6%] vs. 28/289 [9.7%]; OR = 0.77; p = 0.38). The overall detection rate of sentinel lymph nodes, lymph flow, and metastatic rate of ICG‐positive nodes with the help of ICG‐FI were 86.8%, 89.9%, and 22.8%, respectively. No patients experienced major adverse events during ICG injection preoperatively or postoperatively.ConclusionsIndocyanine green fluorescence imaging‐guided procedure, compared to conventional laparoscopic dissection, can assist in obtaining a greater number of harvested lymph nodes and metastatic lymph nodes, however, it did not significantly improve the long‐term clinical outcomes.Level of evidenceLevel III systematic review of randomized control and nonrandomized studies.
Introduction: Education as Cultural and Ecological Revitalization Among Amazonian Nationalities
Authors: Minoia Paola , Arias-Gutiérrez Ruth 
Published: November 2024

AbstractThe chapter introduces the main themes of the book and the theoretical framework, influenced by a decolonial orientation that seeks to support arguments in favour of the recovery of indigenous languages and knowledge, which centuries of white and Eurocentric political and cultural hegemony have led to erasure. If Ecuador is a country where a plurality of populations coexists, these must have equal citizenship, which is also achieved through policies of epistemic justice, starting with the recognition of their cultures and knowledge. The cultural aspect of political rights is normatively recognized by the Constitution and by reforms in public education; to this end, Ecuador, like other countries, has implemented an intercultural education policy. However, this term is widely used with various interpretations, from mere functionalist to radical ones. Therefore, the chapter analyses the relationship between different types of interculturality and the epistemic and political rights of the Indigenous populations and nationalities recognized by the state.
From Discourse to Structure: Interculturality in Amazonian Universities
Authors: Arias-Gutiérrez Ruth , Pérez-Quintana Manuel , Pozo Paola 
Published: November 2024

AbstractThe chapter addresses institutional perspectives on intercultural education within public universities operating in Indigenous territories in the Amazon region. It briefly mentions the Ikiam Regional Amazon University, the revived Intercultural University Amawtay Wasi for Peoples and Indigenous Nations, and focuses on the experience of the Universidad Estatal Amazónica (UEA). The analysis is based on the regional enrollment data, especially those provided by the reports from UEA academic information systems and Senescyt-Unesco on mainstreaming equality. The chapter explores perspectives on access and the importance of higher public education for students in the region, with a focus on interculturality.
Participatory Design Interventions: Supporting University Student Care Networks During Covid
Authors: Pinto Nathaly , Barriga-Abril Xavier , Machoa Katy , Minoia Paola 
Published: November 2024

AbstractThe chapter presents research on a participatory project aimed at supporting and expanding student care networks during the Coronavirus pandemic. It features the process and products of transdisciplinary, intercultural collaboration involving tourism, biology, and environment students from the Universidad Estatal Amazónica and design students from the Pontificia Universidad Católica del Ecuador. The pandemic deepened the existing adverse socioeconomic conditions of Amazonian students, significantly affecting their well-being and access to higher education. Employing a situated, participatory design approach rooted in the Global South and an participatory action research framework, students developed together interactive activities fostering further connection, support, and care for one another amid the emergency. We reflect on the design intervention process and its outcomes, offering insights for organizing and adapting university responses to crises focused on student well-being. This project’s critical analysis could help shape future efforts to broaden the impact of participatory design and decolonial processes in education and intercultural spaces of resilience.
Age Simulation Suits—The First Step in Creating Empathy und Understanding for the Elderly
Authors: Lauenroth Andreas , Schulze Stephan , Teichmann Birgit , Laudner Kevin , Delank Karl-Stefan , Schwesig René 
Published: November 2024

AbstractChanges in medicine, education, and technology have led to a marked increase in life expectancy. Most people now live longer, which, in addition to dropping birth rates, leads to ageing societies with higher proportions of active years. This trend applies to many Western countries, in which there have been an observed increase in age-related physical limitations, such as visual and/or other sensory impairments, and a decrease in physical strength in older adults. These limitations mean that various daily activities and environmental conditions are becoming increasingly complex and difficult for older adults. The physical ageing process and its effects are therefore particularly important from medical, economic, and social perspectives. Although an ageing population can pose numerous challenges to society, it also offers significant opportunities to re-engineer the environment and education to accommodate shifting demographics. The need for insights into older adults’ experiences is urgent. Use of an age simulation suit allows users to experience the physical limitations experienced by older adults. This simulation aid can positively influence one’s perspective of the behaviour and needs of older adults. These results may also broaden the perspectives of those who have a direct or indirect relationship with older adults through increased empathy.
Project Case: Promotion of Dual Vocational Education in Panjin—Geriatric Nursing at Panjin’s Vocational and Technical College
Authors: Lin Li , Fründt Annika 
Published: November 2024

AbstractThe availability of highly qualified specialists, with technical as well as practical skills, is crucial for the long-term economic success of the north-eastern Chinese city of Panjin, as ranked both nationally and internationally.