bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case–control study
Authors: Hamann C.R. , Egeberg A. , Silverberg J.I. , Gislason G. , Skov L. , Thyssen J.P. 
Published: February 2019

AbstractBackgroundAtopic dermatitis (AD) is associated with many autoimmune diseases, in part due to overlapping genetic risk loci. While parental atopic disease is an important risk for AD in the offspring, little is known on the putative associations between parental autoimmune disease and AD in their children.Materials and methodsAll children born between 1996 and 2011 who received a diagnosis of AD in the hospital system before their fifth birthday were matched 1 : 10 with children from the general population. Maternal and paternal autoimmune diseases were assessed using registry‐based data. Conditional logistic regression was performed on the relationships between parental autoimmune diseases and AD in their children.ResultsA total of 8589 children with AD were matched with controls. One or more autoimmune disease was identified in 5.89% (506/8589) of mothers to AD children and 3.67% (315/8589) of fathers to AD children compared to 4.85% (4163/85 890) and 3.28% (2816/85 890) in parents of control children. Maternal autoimmune disease but not paternal autoimmune disease was associated with AD in the offspring (odds ratio [OR] 1.20 [95% confidence interval (CI) 1.20–1.32] and OR 1.08 [0.96–1.22], respectively), Two or more maternal autoimmune diseases, maternal dermatologic autoimmune disease and maternal digestive autoimmune disease were all also associated with AD development in her children (1.96 [95% CI 1.36–2.84], OR 1.60 [95% CI 1.24–2.07] and OR 1.24 [95% CI 1.06–1.45], respectively).ConclusionsThe risk of AD is influenced by many factors including atopy status and filaggrin gene mutations. In this matched case–control study, maternal autoimmune disease was associated with AD diagnosis in the offspring. Maternal dermatologic and digestive autoimmune diseases were most closely associated with subsequent AD diagnosis in the offspring.
Austral Summer Bloom of Loricate Choanoflagellates in the Central Ross Sea Polynya
Authors: Escalera Laura , Mangoni Olga , Bolinesi Francesco , Saggiomo Maria 
Published: February 2019

AbstractA bloom of loricate choanoflagellates was recorded for the first time in the Ross Sea polynya during the austral summer 2017. Both individual cells and uncommon large‐size colonies (200 μm length) represent the 42–55% of the total plankton community (i.e. specimens from 5 to 150 μm length). Choanoflagellates serve as a link between low and mid trophic levels since they prey on bacteria and in turn are ingested by zooplankton. This twofold role and the unusual abundance recorded in the Antarctic ecosystem may have relevant but still unknown effects on food web structure and dynamics in that area.
Safety and efficacy of elbasvir/grazoprevir in Asian participants with hepatitis C virus genotypes 1 and 4 infection
Authors: Wei Lai , Kumada Hiromitsu , Perumalswami Ponni V , Tanwandee Tawesak , Cheng Wendy , Heo Jeong , Cheng Pin‐Nan , Hwang Peggy , Mu Sheng Mei , Zhao Xu Min , Asante‐Appiah Ernest , Caro Luzelena , Hanna George J , Robertson Michael N , Haber Barbara A , Talwani Rohit 
Published: February 2019

AbstractBackground and AimEstimates suggest that in Asia, more than 31 million individuals have hepatitis C virus infection. The present analysis was conducted to assess the efficacy and safety of elbasvir/grazoprevir in Asian participants enrolled in the elbasvir/grazoprevir phase 2/3 clinical trials.MethodsThis is an integrated analysis of data from 12 international phase 2/3 clinical trials. Asian participants with chronic hepatitis C virus genotype 1 or 4 infection who received elbasvir 50 mg/grazoprevir 100 mg once daily for 12 weeks or elbasvir/grazoprevir plus ribavirin for 16 weeks were included in this analysis. The primary end point was sustained virologic response at 12 weeks after completion of therapy (SVR12).ResultsSeven hundred eighty Asian participants from 15 countries were included in this analysis. SVR12 was achieved by 756/780 (96.9%) of all participants, including 748/772 (96.9%) of those who received elbasvir/grazoprevir for 12 weeks and 8/8 (100%) of those who received elbasvir/grazoprevir plus ribavirin for 16 weeks. In the genotype 1b‐infected population, the SVR12 rate was 691/709 (97.5%), and there was no impact of age, high baseline viral load, or presence of cirrhosis. The most frequently reported adverse events were nasopharyngitis (8.0%), upper respiratory tract infection (5.4%), and diarrhea (5.2%). Twenty participants receiving elbasvir/grazoprevir for 12 weeks reported a total of 25 serious adverse events, and 7 (0.9%) discontinued treatment because of an adverse event.ConclusionElbasvir/grazoprevir administered for 12 weeks is an effective and generally well‐tolerated treatment option for Asian individuals with hepatitis C virus genotype 1b infection.
Dysregulation of collagen expression in peri‐implantation endometrium of women with high ovarian response
Authors: Li Mingyang , Yao Lihua , Xin Meizhen , Gao Minzhi 
Published: February 2019

AbstractAimTo analyze the effects of high ovarian response on endometrial collagen synthesis and related gene expression during the peri‐implantation period in patients undergoing in vitro fertilization‐embryo transfer.MethodsPeripheral blood and endometrial biopsies were obtained from infertile women on day 6 after oocytes retrieval or ovulation in 16 stimulated cycles (SC) and 16 natural cycles (NC) respectively. Serum estrogen (E2), progesterone (P4), histological staging, endometrial collagen, matrix metalloproteinases (MMP2, 9) and tissue inhibitors of metalloproteinases (TIMP1, 3) were assayed.ResultsSerum levels of both E2 and P4 were significantly higher in the SC group than those in the NC group. All endometrial samples were in the secretory phase. The collagen in the stroma of the SC group was more dense and higher than that in the NC group. MMP2 and MMP9 were detected significantly lower in the SC group than those in the NC group, while TIMP1 and TIMP3 were significantly higher. MMP2, 9 expressions are increased by estrogen and reduced by progesterone in dose‐dependent manner through estrogen receptor and progesterone receptor. Correspondingly, TIMP1, 3 expressions decreased by estrogen dose‐dependently while progesterone played the opposite role.ConclusionHigh levels of P4 could stimulate excessive synthesis of collagen in peri‐implantation endometrium of women with high ovarian response, and the mechanisms may be related to the decrease of MMP2, 9 and the increase of TIMP1, 3 through P4 receptor.
Excellence‐Prior Eudaimonism
Authors: Herdt Jennifer A. 
Published: February 2019

AbstractEudaimonism is often regarded as egoistic. If it recommends that agents pursue their own good because it is their own good, it is guilty as charged. But excellence‐prior eudaimonism offers a non‐egoistic alternative to this welfare‐prior eudaimonism. Excellence‐prior eudaimonism recommends that an agent live in a way that is in fact good for the agent, but it does not regard the agent’s own good as necessarily that for the sake of which the agent acts, nor does it regard living well as justified by the fact that it is good for the agent, but simply because it is good. The Christian eudaimonisms of Augustine and Aquinas are best understood as deepened forms of excellence‐prior eudaimonism.
Witnessing Whiteness in the Ethics of Hauerwas
Authors: Norris Kristopher 
Published: February 2019

AbstractDespite constituting one of the most pressing ethical issues of our time, most white Christian ethicists and theologians fail to engage the issue of white supremacy in their work. As one of the most influential and prolific Christian ethicists of the past half‐century, Stanley Hauerwas represents this tendency, and provides specific reasons for his silence. This essay analyzes those reasons, and argues that a commitment to Alasdair MacIntyre’s understandings of tradition and narrative frames his view on race and prevents his engagement of racism. It then highlights the ways this reflects the broader trends of silence, abstraction, and colorblindness among white Christian ethicists when it comes to the issue. Identifying these failures, the essay concludes by suggesting that Hauerwas’s first published essay in 1969, on Black Power, provides resources for theologically engaging the problems of white supremacy today.
The Cultural Turn: Empirical Studies and their Implications
Authors: Moret Ross 
Published: February 2019

AbstractThis essay uses empirical studies to engage Richard Miller’s advocacy of a “cultural turn” in the study of religious ethics found in Friends and Other Strangers. The particular kind of empirical research I highlight here, cultural cognition, emphasizes the ways that belonging to a cultural group influences one’s reasoning when faced with controversial issues involving disputed facts. This approach underscores the significance of the cultural turn, but it also raises some important challenges for Miller’s accounts of moral psychology and public reason. I work to elucidate what those challenges are and point to some ways that taking cultural cognition seriously might open up fresh avenues for addressing perennial ethical issues.
“You are your only limit”: Appropriations and valorizations of affect in university branding
Authors: Ng Carl Jon Way 
Published: February 2019

AbstractThis article considers the role of affect in university branding in a context of neoliberal higher education, by way of examining the semiotic landscape of the Singapore Management University concourse. Contemporary branding often involves stimulating stakeholder/audience investments of meaning and affect into the brand, thereby appropriating consumers’ affective labour for brand‐building and communications. Adopting a discourse‐analytic approach, I examine how linguistic, visual and spatial modalities are utilized to evoke and semiotize particular affective meanings and orientations in the emplaced discourse within the university's brand space. This discourse, which includes organizational branding discourse as well as more organic student‐generated texts, becomes part of the affective regime, helping to encourage and enjoin what is deemed to be normative affective sensibilities and practices in that context. Consequently, the article also considers the kinds of affective subjectivities that are valorized, and how stakeholder/student‐subjects are interpellated in a context of neoliberal‐oriented higher education.
The association of indoxyl sulfate with fibroblast growth factor‐23 in cats with chronic kidney disease
Authors: Liao Yu‐Lun , Chou Chi‐Chung , Lee Ya‐Jane 
Published: February 2019

BackgroundIndoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor‐23 (FGF‐23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF‐23 holds true for cats with CKD.HypothesisAccumulation of IS is related to FGF‐23 secretion in cats with CKD.AnimalsTwenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively.MethodsThe concentrations of IS and FGF‐23 in plasma were determined by high‐performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months.ResultsPlasma IS and FGF‐23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF‐23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF‐23 and phosphate. When the renal progression group was compared with the non‐progression group, both IS and FGF‐23 were found to be significantly increased (P < .05). In addition, the area under receiver operator curve of the combination of IS and FGF‐23 predicted renal progression at a level >0.9.Conclusions and Clinical ImportanceBoth FGF‐23 and IS are associated with phosphate metabolism and CKD progression.
Reclassification of four aubrites as enstatite chondrite impact melts: Potential geochemical analogs for Mercury
Authors: Udry Arya , Wilbur Zoë E. , Rahib Rachel R. , McCubbin Francis M. , Vander Kaaden Kathleen E. , McCoy Timothy J. , Ziegler Karen , Gross Juliane , DeFelice Christopher , Combs Logan , Turrin Brent D. 
Published: February 2019

AbstractWe present petrologic and isotopic data on Northwest Africa (NWA) 4799,NWA7809,NWA7214, andNWA11071 meteorites, which were previously classified as aubrites. These four meteorites contain between 31 and 56 vol% of equigranular, nearly endmember enstatite, Fe,Ni metal, plagioclase, terrestrial alteration products, and sulfides, such as troilite, niningerite, daubréelite, oldhamite, and caswellsilverite. The equigranular texture of the enstatite and the presence of the metal surrounding enstatite indicate that these rocks were not formed through igneous processes like the aubrites, but rather by impact processes. In addition, the presence of pre‐terrestrially weathered metal (7.1–14 vol%), undifferentiated modal abundances compared to enstatite chondrites, presence of graphite, absence of diopside and forsterite, low Ti in troilite, and high Si in Fe,Ni metals suggest that these rocks formed through impact melting on chondritic and not aubritic parent bodies. Formation of these meteorites on a parent body with similar properties to theEHa enstatite chondrite parent body is suggested by their mineralogy. These parent bodies have undergone impact events from at least 4.5 Ga (NWA 11071) until at least 4.2 Ga (NWA 4799) according to39Ar‐40Ar ages, indicating that this region of the solar system was heavily bombarded early in its history. By comparingNWAenstatite chondrite impact melts to Mercury, we infer that they represent imperfect petrological analogs to this planet given their high metal abundances, but they could represent important geochemical analogs for the behavior and geochemical affinities of elements on Mercury. Furthermore, the enstatite chondrite impact melts represent an important petrological analog for understanding high‐temperature processes and impact processes on Mercury, due to their similar mineralogies, Fe‐metal‐rich and FeO‐poor silicate abundances, and low oxygen fugacity.
Identifying coaching skills to improve feedback use in postgraduate medical education
Authors: Armson Heather , Lockyer Jocelyn M , Zetkulic Marygrace , Könings Karen D , Sargeant Joan 
Published: February 2019

ObjectivesCoaching in medical education has recently gained prominence, but minimal attention has been given to key skills and determining how they work to effectively ensure residents are progressing and developing self‐assessment skills. This study examined process‐oriented and content‐oriented coaching skills used in coaching sessions, with particular attention to how supervisors use them to enhance resident acceptance of feedback to enhance learning.MethodsThis qualitative study analysed secondary audiotaped data from 15 supervisors: resident dyads during two feedback sessions, 4 months apart. The R2C2 model was used to engage the resident, build a relationship, explore reactions to feedback, explore resident perceptions of content, and coach for change. Framework analysis was used, including familiarisation with the data, identifying the thematic framework, indexing and charting the data and mapping and interpretation.ResultsProcess skills included preparation, relationship development, using micro communication skills and techniques to promote reflection and self‐assessment by the resident and supervisor flexibility. Content skills related to the specific feedback content included engaging the resident in discussion, ensuring the discussion was collaborative and focused on goal setting, co‐developing a Learning Change Plan, ensuring resident commitment and following up on the plan. Together, these skills foster agency in the resident learner. Three overarching themes emerged from the analysis: the interconnectedness of process and content; tensions between encouraging self‐direction and ensuring progress and competence; and balancing a coaching dialogue and a teaching monologue.ConclusionsEffective coaching by supervisors requires a combination of specific process and content skills that are chosen depending on the needs of the individual resident. Mastering these skills helps residents engage and develop agency in their own professional development. These outcomes depend on faculty maintaining a balance between coaching and teaching, encouraging resident self‐direction and ensuring progression to competence.
Insecticide susceptibility status and major detoxifying enzymes activity in Anopheles subpictus from Kasur, Pakistan
Authors: Naeem H. , Oneeb M. , Ashraf K. , Rashid M. I. , Nazir M. M. , Tabassum S. 
Published: February 2019

AbstractAnopheles subpictus s.l. Grassi (Diptera: Culicidae) is a malaria vector in South Asia, where insecticides are the mainstay for vector control interventions. Information on any variation in metabolic enzyme levels in mosquitoes is helpful with respect to adapting alternative strategies for vector control. The scarce data on the biochemical basis of insecticide resistance in malaria vectors of Pakistan limit the available information for vector control interventions within the country. The insecticide susceptibility status and its biochemical basis against dichlorodiphenyltrichloroethane (DDT) (4%), deltamethrin (0.05%) and permethrin (0.75%) in An. subpictus s.l. collected from all Tehsils of district Kasur were evaluated. For this purpose, a World Health Organization susceptibility bioassay was performed followed by the detection of altered metabolic enzyme activity using biochemical assays. Similarly, a significant difference in knock‐down effect was observed among field collected and susceptible strain against all insecticides 24 h post exposure. The overall mean mortality rates of DDT, deltamethrin and permethrin were 27.86% [95% confidence interval (CI) = 29.65–26.06], 44.89% (95% CI = 46.23–43.54) and 78.82% (95% CI = 80.16–77.47), respectively. The biochemical assays revealed an elevated level of metabolic enzymes in the field population. The results provide evidence of resistance against organochlorine and pyrethroid groups in a field population of An. subpictus s.l. from district Kasur mediated by multiple metabolic mechanisms, including acetylcholinesterases, esterases, cytochrome P450 and glutathione S‐transferases.
Healthcare utilization in patients with first‐time implantable cardioverter defibrillators (data from the WEBCARE study)
Authors: Broers Eva R. , Lodder Paul , Spek Viola R.M. , Widdershoven Jos W.M.G. , Pedersen Susanne S. , Habibović Mirela 
Published: February 2019

AbstractBackgroundKnowledge of the level of healthcare utilization (HCU) and the predictors of high HCU use in patients with an implantable cardioverter defibrillator (ICD) is lacking. We examined the level of HCU and predictors associated with increased HCU in first‐time ICD patients, using a prospective study design.MethodsICD patients (N = 201) completed a set of questionnaires at baseline and 3, 6, and 12 months after inclusion. A hierarchical multiple linear regression with three models was performed to examine predictors of HCU.ResultsHCU was highest between baseline and 3 months postimplantation and gradually decreased during 12 months follow‐up. During the first year postimplantation, only depression (β = 0.342, P = 0.002) was a significant predictor. Between baseline and 3 months follow‐up, younger age (β = −0.220, P < 0.01), New York Heart Association class III/IV (β = 0.705, P = 0.01), and secondary indication (β = 0.148, P = 0.05) were independent predictors for increased HCU. Between 3 and 6 months follow‐up, younger age (β = −0.151, P = 0.05) and depression (β = 0.370, P < 0.001) predicted increased HCU. Between 6 and 12 months only depression (β = 0.355, P = 0.001) remained a significant predictor.ConclusionsDepression was an important predictor of increased HCU in ICD patients in the first year postimplantation, particularly after 3 months postimplantation. Identifying patients who need additional care and provide this on time might better meet patients’ needs and lower future HCU.
Importance of the vein of Marshall involvement in mitral isthmus ablation
Authors: Fujisawa Taishi , Kimura Takehiro , Nakajima Kazuaki , Nishiyama Takahiko , Katsumata Yoshinori , Aizawa Yoshiyasu , Fukuda Keiichi , Takatsuki Seiji 
Published: February 2019

AbstractBackgroundEpicardiac conduction via the vein of Marshall (VOM) can bypass the mitral isthmus (MI) line, making MI ablation difficult. This study aimed to assess the contribution of the VOM in achieving MI conduction block.MethodsThis study included 143 consecutive patients with nonparoxysmal atrial fibrillation who underwent initial MI ablation. They were retrospectively classified into two groups, a VOM‐guided group (n = 28) and a conventional group (n = 115), according to the use of a 2‐Fr electrode catheter inserted in the VOM. The acute success rate of achieving MI block and the ablation data were assessed. When the bidirectional block was verified exclusively in the VOM or coronary sinus (CS) electrodes, we defined it as a pseudo MI block. In the VOM‐guided group, we ascertained the complete MI block, verified both in the VOM and CS electrodes.ResultsIn the VOM‐guided group, the pseudoblock was observed in 33.3% of the patients during MI ablation. With significantly less radiofrequency energy (19 322.6 ± 11 352.8 vs 25 389.3 ± 19 951.9, P = 0.04), we achieved a similar level of success rate in MI ablation in the VOM‐guided group (96.4% vs 91.3%, P = 0.36). Notably, after achieving complete MI block, atrial burst pacing induced two perimitral flutters in the VOM‐guided group, which were successfully terminated by the additional radiofrequency application.ConclusionsAssessment of electrical conduction through the VOM could clarify the existence of a pseudo MI conduction block. However, the existence of a slow conduction through the MI could be detected only after induction of perimitral atrial tachycardia with atrial programmed stimulation.