bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect Reconstruction
Authors: Zhang Boqing , Wang Kaixin , Gui Xingyu , Wang Wenzhao , Song Ping , Wu Lina , Guo Likun , Zhou Changchun , Fan Yujiang , Zhang Xingdong 
Published: November 2024

AbstractPorous calcium phosphate ceramics have attracted widespread attention owing to their excellent bioactivity. However, their poor mechanical properties severely limit their clinical applications. Significantly improving the mechanical strength of porous CaP ceramics while maintaining their bioactivity remains a major challenge. To address this issue, calcium sulfate is used to regulate the directional growth of hydroxyapatite grains during ceramic sintering. The in situ oriented grains can not only alleviate the stress concentration but also strengthen the bonding force between the ceramic grain boundaries. Calcium sulfate improves the release of active calcium ions from calcium phosphate ceramics, further enhancing their bioactivity and osteoinductivity in vivo. Transcriptome and proteome sequencing reveals that the in situ whisker‐reinforced ceramics increase the expression of proteins related to calcium ion binding and promote the expression of osteogenesis‐related proteins. In the supercritical bone defect repair model, repair of the defect is achieved within 3 months, with mechanical recovery reaching more than 70% of the autologous bone.
N6‐Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression
Authors: Rui Yalan , Zhang Haisheng , Yu Kangning , Qiao Shiyao , Gao Chenglin , Wang Xiansong , Yang Weifeng , Asadikaram Gholamreza , Li Zigang , Zhang Kun , Peng Jianxin , Li Jiexin , He Junming , Wang Hongsheng 
Published: November 2024

AbstractPrimary cilia are microtubule‐based organelles that function as cellular antennae to address multiple metabolic and extracellular cues. The past decade has seen significant advances in understanding the pro‐tumorigenic role of N6‐methyladenosine (m6A) modification in tumorigenesis. Nevertheless, whether m6A modification modulates the cilia dynamics during cancer progression remains unclear. Here, the results show that m6A methyltransferase METTL3 regulates cilia length in cancer cells via HDAC6‐dependent deacetylation of axonemal α‐tubulin, thereby controlling cancer development. Mechanically, METTL3 positively regulates the translation of HDAC6 in an m6A‐dependent manner, while m6A methylation of A3678 in the coding sequence (CDS) of HDAC6 ameliorates its translation efficiency via facilitating the binding with YTHDF3. The upregulation of HDAC6 induced by METTL3 over‐expression is capable of inhibiting cilia elongation and acetylation of α‐tubulin, thereby shortening cilia length and accelerating the progression of cervical cancer both in vitro and in vivo. Collectively, depletion of METTL3‐mediated m6A modification leads to abnormally elongated cilia via suppressing HDAC6‐dependent deacetylation of axonemal α‐tubulin, ultimately attenuating cell growth and cervical cancer development.
Molecular Crowding Solid Polymer Electrolytes for Lithium Metal Battery by In Situ Polymerization
Authors: Zhou Mingjie , Chen Wei , Yang Hui , Hu Yin , Lei Tianyu , Chen Dongjiang , Wang Shuying , Zhang Yagang , Xiong Jie 
Published: November 2024

AbstractSolid‐state polymer electrolytes (SPEs) require high ionic conductivity and dense contact with the electrodes for high‐performance lithium‐metal solid‐state batteries. However, massive challenges such as poor ionic migration ability, low antioxidant ability, and lithium dendrite formation still remain unresolved. These issues severely restrict its practical applications. Herein, a new type of solid‐state polymer electrolyte with a molecular crowding feature is rationally designed by in situ polymerization of a precursor containing poly (ethylene glycol) diacrylate (PEGDA) and 1,2‐dimethoxyethane (DME). Noticeably, the prepared SPE expands the electrochemical window to 4.7 V with a high lithium‐ion transfer number of 0.55 and a superior ionic conductivity of 3.6 mS cm−1 at room temperature. As a result, the lithium symmetrical batteries achieve stable cycles with more than 3000 h with no lithium dendrites at a current density of 0.5 mA cm−2. Importantly, this design provides dense contact of solid‐state polymer electrolytes with the porous cathode and lithium anode, allowing the assembled winding‐type solid‐state pouch cells with outstanding cycling stability of 81.7% retention for more than 340 cycles at room temperature. It shows excellent adaption to widely practical technology with large‐scale battery production, offering a new solution for the future development of solid‐state polymer lithium‐metal batteries.
Dual‐Site Anchors Enabling Vertical Molecular Orientation for Efficient All‐Perovskite Tandem Solar Cells
Authors: Bao Yuqi , Zeng Jie , Xu Yintai , Xie Guanshui , Hu Hang , Lei Xia , Wang Deng , Zhang Jiyao , Peng Wenbo , Liu Zhixin , Zhu Peide , Qu Geping , Qiu Longbin , Yan Lei , Zhang Yong , Wang Xingzhu , Xu Baomin 
Published: November 2024

AbstractAll‐perovskite tandem solar cells (TSCs) are gaining increasing attention due to their potential to surpass the efficiency limit of single‐junction solar cells. However, as the bottom low‐bandgap subcells, tin‐lead (Sn‐Pb) perovskites suffer from severe nonradiative recombination at the interfaces due to their susceptibility to oxidation and poor crystalline morphology. Here a surface modifier 4‐(trifluoromethyl)benzhydrazide (TFH) is reported to construct a reductive chemical environment on the surface of perovskite films and protect them from water and oxygen erosion. TFH anchors onto the Sn‐Pb perovskites in a preferred vertical orientation through dual‐site binding, forming interface dipoles that facilitate charge extraction. The reductive hydrazine groups of TFH can effectively inhibit the oxidation of Sn2+ and I−, thereby reducing the defect density and energy disorder of Sn─Pb perovskites. Consequently, the TFH‐treated devices achieved a champion PCE of 22.88%, maintaining over 93% of the initial efficiency after continuous one‐sun illumination for 500 h. Combined with a 1.79 eV wide‐bandgap subcell, it has demonstrated a PCE of 28.17% in all‐perovskite TSCs.
Liquid holdup of gas–liquid two‐phase flow in micro‐packed beds reactors
Authors: Chen Keyi , Lu Yangcheng 
Published: November 2024

AbstractLiquid holdup is a crucial factor in the study of hydrodynamic behaviors in the micro‐packed bed reactor (μPBR). In this work, the values of liquid holdup are studied with the weighing method with good accuracy. The packed bed is a tube made of stainless steel with a length of 20 cm and an inner diameter of 4 mm, packed with 177–250 μm or 350–500 μm microbeads. The gas and liquid flow rates vary from 5 to 20 mL/min and 0.25 to 2 mL/min, respectively. A new hypothesis of the flow regions is proposed based on the experimental results. Furthermore, a new set of empirical correlation is built with great agreement, particularly for viscous liquids, whose viscosity ranges from 0.99 to 5.98 mPa·s, showing an atypical tendency.
Functional 1,2,4,5‐Tetrazine Systems for Photocatalysis and Sensing
Authors: Raj K. Aswani , Rao M. Rajeswara 
Published: November 2024

Abstracts‐Tetrazines are aromatic heterocyclic systems with distinct structural and optoelectronic features, which have led to the design and development of tetrazine‐derived systems in various applications. In this review, we summarize all the research reported on the subject of the applicability of tetrazine derivatives for photocatalytic chemical transformation, hydrogen production, and coordination‐based analyte detection.
Revealing Dinitrogen Activation via Mesoionic Carbenes: A Computational Design with Frustrated Lewis Pairs
Authors: Huang Shiqing , Wang Tian , Zhang Zengyu , Yan Xiaoyu 
Published: November 2024

AbstractActivating dinitrogen under metal‐free conditions remains a significant challenge in chemistry. In this study, we computationally designed a frustrated Lewis pair (FLP) system incorporating a bis(trimethylsilyl)boryl substituent on a mesoionic carbene (MIC) framework. Our models show both kinetic and thermodynamic favorability for dinitrogen activation. Aromaticity enhancement along the potential energy surface (PES) plays a critical role in driving the reaction. This work provides insights into utilizing main‐group elements for dinitrogen activation and offers potential applications in inert molecule activation and optical materials.
Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research
Authors: Nuytemans Karen , Franzen Sanne , Broce Iris J. , Caramelli Paulo , Ellajosyula Ratnavalli , Finger Elizabeth , Gupta Veer , Gupta Vivek , Illán‐Gala Ignacio , Loi Samantha M. , Morhardt Darby , Pijnenburg Yolande , Rascovsky Katya , Williams Monique M. , Yokoyama Jennifer S. , Acosta‐Uribe Juliana , Akinyemi Rufus , Alladi Suvarna , Ayele Biniyam A. , Ayhan Yavuz , Bourdage Renelle , Castro‐Suarez Sheila , de Souza Leonardo Cruz , Dacks Penny , de Boer Sterre C. M. , de Leon Jessica , Dodge Shana , Grasso Stephanie , Ghoshal Nupur , Kamath Vidyulata , Kumfor Fiona , Matias‐Guiu Jordi A. , Narme Pauline , Nielsen T. Rune , Okhuevbie Daniel , Piña‐Escudero Stefanie , Ruiz‐Garcia Ramiro , Ryan Brigid , Scarioni Marta , Slachevsky Andrea , Suarez‐Gonzalez Aida , Tee Boon Lead , Tsoy Elena , Ulugut Hulya , Onyike Chiadi U. , Babulal Ganesh M. ,   ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA
Published: November 2024

AbstractFrontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross‐cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.
Thorase deficiency causes both Aβ accumulation and tau hyperphosphorylation in mouse brain
Authors: Zhang Han , Cai Menghua , Gao Fei , Yang Jia , Li Chao , Han Jingyi , Wang Yue , Xu Yi , Hu Yu , Chen Hui , He Wei , Zhang Jianmin 
Published: November 2024

AbstractINTRODUCTIONThe pathogenesis of two major pathogenic characters—amyloid beta (Aβ) accumulation and hyperphosphorylated tau protein—in the brains of patients with Alzheimer's disease (AD) remains unclear.METHODSWestern blot and immunofluorescence staining were performed to detect the proteins in the brains of Thorase conditional knockout/transgenic mice and their littermates. A co‐immunoprecipitation assay was applied to examine the Thorase‐interacting proteins.RESULTSGenetic deletion of Thorase resulted in tau hyperphosphorylation and promoted Aβ accumulation in the mouse brain. Conversely, Thorase overexpression alleviated the pathogenesis of AD. Thorase regulated the phosphorylation of tau by targeting specific kinases and theprotein phosphatase 2B (PP2B). Thorase deficiency also impaired microglial phagocytosis and induced neuroinflammation by the activation of the NOD‐like receptor thermal protein domain associated protein 3 (NLRP3) inflammasomes in microglia.DISCUSSIONThorase may be a potential druggable target for developing therapeutic approaches to treat AD and other neurodegenerative diseases.Highlights
Thorase deletion leads to elevated amyloid beta (Aβ) deposition and hyperphosphorylated tau accumulation in the brain.
Thorase regulates the phosphorylation of tau protein via PP2B.
Thorase deficiency impairs microglial phagocytosis and promotesNLRP3‐mediated neuroinflammation.
Overexpression of Thorase alleviates Aβ deposition and tau phosphorylation in the AD mouse model.
Cerebral perfusion and amyloidosis in the oldest‐old
Authors: Dutt Shubir , Woodworth Davis C. , Sajjadi S. Ahmad , Greenia Dana E. , DeCarli Charles , Kawas Claudia H. , Corrada María M. , Nation Daniel A. 
Published: November 2024

AbstractINTRODUCTIONIn a nested case–control study, we examined how cerebral perfusion relates to cognitive status and amyloid in the oldest‐old (i.e., 90 years of age and older).METHODSStudy participants included 113 dementia‐free older adults (76 cognitively normal [CN]; 37 cognitively impaired, no dementia [CIND]) from the 90+ Study (mean age = 92.9, SD = 2.4). We quantified regional perfusion from arterial spin labeling‐MRI (magnetic resonance imaging) and amyloid deposition from florbetapir‐positron emission tomography (PET) in a region comprising the posterior cingulate and precuneus (PCC+PCu), and additionally quantified perfusion in other regions important for cognitive decline (medial temporal lobe, inferior parietal lobe, and orbitofrontal cortex).RESULTSParticipants with CIND displayed lower perfusion in the PCC+PCu relative to participants who were CN, but there was no statistically significant difference between the groups in amyloid burden in this region. In addition, participants with CIND exhibited lower inferior parietal and higher orbitofrontal perfusion.DISCUSSIONCerebral perfusion is related to cognitive status in the oldest‐old independent of amyloidosis.Highlights
Cerebral perfusion and amyloid positron emission tomography (PET) were measured in older adults: 90 years of age and older.
Perfusion but not amyloid differed between cognitively impaired and normal groups.
Frontal and parietal regions linked to cognitive decline had altered perfusion.
Perfusion is related to cognitive status in the oldest‐old independent of amyloid.
Integrated cerebellar radiomic‐network model for predicting mild cognitive impairment in Alzheimer's disease
Authors: Chen Yini , Qi Yiwei , Hu Yiying , Qiu Xinhui , Qiu Tao , Li Song , Liu Meichen , Jia Qiqi , Sun Bo , Liu Cong , Li Tianbai , Le Weidong ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: November 2024

AbstractINTRODUCTIONPathological and neuroimaging alterations in the cerebellum of Alzheimer's disease (AD) patients have been documented. However, the role of cerebellum‐derived radiomic and structural connectome modeling in the prediction of AD progression remains unclear.METHODSRadiomic features were extracted from magnetic resonance imaging (MRI) in the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset (n = 1319) and an in‐house dataset (n = 308). Integrated machine learning models were developed to predict the conversion risk of normal cognition (NC) to mild cognitive impairment (MCI) over a 6‐year follow‐up.RESULTSThe cerebellar models outperformed hippocampal models in distinguishing MCI from NC and in predicting transitions from NC to MCI across both cohorts. Key predictors included textural features in the right III and left I and II lobules, and network properties in Vermis I and II, which were associated with cognitive decline in AD.DISCUSSIONCerebellum‐derived radiomic‐network modeling shows promise as a tool for early identification and prediction of disease progression during the preclinical stage of AD.Highlights
Altered cerebellar radiomic features and topological networks were identified in the subjects with mild cognitive impairment (MCI).
The cerebellar radiomic‐network integrated models outperformed hippocampal models in distinguishing MCI from normal cognition.
The cerebellar radiomic model effectively predicts MCI risk and can stratify individuals into distinct risk categories.
Specific cerebellar radiomic features are associated with cognitive impairment across various stages of amyloid beta and tau pathology.
An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings
Authors: Volkmer Anna , Alves Emily Viega , Bar‐Zeev Hagit , Barbieri Elena , Battista Petronilla , Beales Ashleigh , Beber Barbara Costa , Brotherhood Emilie , Cadorio Ines Ribeiro , Carthery‐Goulart Maria Teresa , Cartwright Jade , Crutch Sebastian , Croot Karen , Freitas Maria Isabel d´Ávila , Gallée Jeanne , Grasso Stephanie M. , Haley Katarina , Hendriksen Heleen , Henderson Shalom , Jiskoot Lize , Almeida Isabel Junqueira , Kindell Jackie , Kingma Rachel , Kwan‐Chen Lorinda LY , Lavoie Monica , Lifshitz‐Ben‐Basat Adi , Jokel Regina , Mahut‐Dubos Aurore , Matias‐Guiu Jordi A. , Masson‐Trottier Michèle , Meinzer Marcus , McGowan Ellen , Mendez‐Orellana Carolina , Meyer Aaron M. , Millanski Carly , Montagut Núria , Mooney Aimee , Morhardt Darby J. , Nickels Lyndsey , Norvik Monica , Nowenstein Iris Edda , Paplikar Avanthi , Pozzebon Margaret , Renard Antoine , Ruggero Leanne , Rogalski Emily , Rysop Anna U. , Sand Aronsson Fredrik , Suárez‐González Aida , Savage Sharon , Thi Mai Tran , Tsapkini Kyriana , Taylor‐Rubin Cathleen , Tippett Donna C. , Unger Nina , van Ewijk Lizet , Wielaert Sandra , Winsnes Ingvild Elisabeth , Whitworth Anne , Yasa Ibrahim Can , Copland David , Henry Maya L. , Warren Jason D. , Varley Rosemary , Wallace Sarah J. , Hardy Chris J. D. 
Published: November 2024

AbstractINTRODUCTIONInterventions to treat speech‐language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of importance to people with PPA that have received less attention.METHODSFollowing Core Outcome Set Standards for Development Recommendations (COSSTAD), this study comprised: Stage 1 – systematic review to identify measures; Stage 2 – consensus groups to identify important outcome constructs for people with PPA (n = 82) and care partners (n = 91); Stage 3 – e‐Delphi consensus with 57 researchers.RESULTSThe systematic review identified 84 Outcome Measurement Instruments. Core outcome constructs identified included: (1) Participate in conversations with family and friends, (2) get words out, (3) be more fluent, (4) convey a message by any means, and (5) understand what others are saying. Researchers were unable to reach a consensus on measurement instruments.DISCUSSIONFurther work is required to develop appropriate measurement instruments that address all core outcome constructs important to key stakeholders.Highlights
We introduce new symptom‐led perspectives on primary progressive aphasia (PPA).
The focus is on non‐fluent/agrammatic (nfvPPA) and semantic (svPPA) variants.
Foregrounding of early and non‐verbal features of PPA and clinical trajectories is featured.
We introduce a symptom‐led staging scheme for PPA.
We propose a prototype for a functional impairment scale, the PPA Progression Planning Aid.
Blood biomarkers in Down syndrome: Facilitating Alzheimer's disease detection and monitoring
Authors: Petersen Melissa E. , Flores‐Aguilar Lisi , Head Elizabeth , Montoliu‐Gaya Laia , Strydom Andre , Pape Sarah E. , Fortea Juan , Ashton Nicholas J. , Udeh‐Momoh Chinedu , O'Bryant Sid E. , German Dwight , Despa Florin , Mapstone Mark , Zetterberg Henrik 
Published: November 2024

AbstractBlood‐based biomarkers continue to be explored for disease detection, monitoring of progression, and therapeutic outcomes as the diagnostic determination of Alzheimer's Disease in Down Syndrome (DS‐AD) remains challenging in clinical settings. This perspective highlights the current status of this effort. Overall, amyloid (A), tau (T), and neurodegeneration (AT[N]) blood‐based biomarkers have been shown to increase with disease pathology for individuals with DS. Phosphorylated tau biomarkers (p‐tau217, p‐tau181) have been consistently shown to track disease progression for DS‐AD and are likely good candidates for use in clinical settings. Biomarkers of inflammation (glial fibrillary acidic protein) also show promise; however, additional work is needed. Findings from stability work of blood‐based biomarkers conducted among non‐DS also support the potential longitudinal utility of biomarkers such as neurofilament light chain and p‐tau181 in DS. Gaps in our knowledge are highlighted, and a potential role for sex differences in biomarker outcomes is noted, along with recommendations for determining the appropriate context of use when translating biomarkers into clinical applications.Highlights
An overview of blood‐based biomarkers for Alzheimer's disease (AD) was provided for consideration of their utility among individuals with Down syndrome when looking toward potential clinical applications.
Longitudinal stability of many blood biomarkers and improvement in detection sensitivity make blood such as plasma a viable source for exploring AD pathology.
Variability in reviewed findings regarding the application of blood biomarkers highlights the importance of understanding and defining the appropriate context of use, particularly when translating them into clinical practice.
A Protocol for Unveiling the Nature of Photocatalytic Hydrogen Evolution Reactions: True Water Splitting or Sacrificial Reagent Acceptorless Dehydrogenation?
Authors: Peng Yong , Rabeah Jabor , Junge Henrik , Beller Matthias 
Published: November 2024

AbstractPhotocatalytic water splitting for hydrogen evolution is a highly topical subject in academic research and a promising approach for sustainable fuel production from solar energy. Due to the mismatched energy diagram of the photosensitizer (especially semiconductor‐based materials where band‐edge engineering is not trivial) and the redox potential of the half‐reactions of water splitting, photocatalytic H2 generation from water splitting is usually accelerated by the addition of hole scavengers, i.e. sacrificial reagents such as alcohols, amines, and thiols. However, the source of the protons of the evolved H2 is often neglected, and it is questionable whether such systems are really water splitting. Here, we discuss recent reports on sacrificial reagent‐assisted photocatalytic water splitting and present our recent findings, which showcase that the sacrificial reagent in the investigated photocatalytic water splitting systems inherently undergoes acceptorless dehydrogenation, with H2O serving as the proton shuttle, the amount of which doesn't change during the course of the reaction.