bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gold(I)‐Catalyzed Cascade Cyclization Reactions of Allenynes for the Synthesis of Fused Cyclopropanes and Acenaphthenes
Authors: Ikeuchi Takaya , Inuki Shinsuke , Oishi Shinya , Ohno Hiroaki 
Published: April 2019

AbstractA gold‐catalyzed reaction of phenylene‐tethered allenynes with benzofurans gave 1‐(naphth‐1‐yl)cyclopropa[b]benzofuran derivatives, whereas the reaction of 1‐allenyl‐2‐ethynyl‐3‐methylbenzene derivatives in the absence of benzofurans gave acenaphthenes in good yields. These results can be rationalized by nucleophilic attack of the alkyne moiety on an activated allene to form a vinyl cation intermediate.
Degradation of hazardous organic dyes with solar‐driven advanced oxidation process catalyzed by the mixed metal–organic frameworks
Authors: Farrokhi Alireza , Feizpour Fahimeh , Asaadzadeh Maryam 
Published: April 2019

phosphonate‐based bimetallic metal‐ organic frameworks, namely STA‐12(M1, M2) (M1, M2 = Mn, Fe, Co), show photocatalytic activity for the degradation of Rhodamine B (RhB) and Methylene blue (MB) from aqueous solution under natural sunlight irradiation. The degradation of the dyes, appears to be faster with STA‐12(Fe, Mn) than other synthesized MOFs. Thus, photo‐Fenton oxidative discoloration of dyes has been studied by H2O2 catalyzed with the STA‐12(Fe, Mn). The process is first order with respect to dyes and the synergistic index in the STA‐12(Fe, Mn)/sunlight/H2O2system reached as high as 472%. Mineralization of dyes was discussed by spectroscopic and TOC measurement. Besides, the efficiency of STA‐12(Fe, Mn) used in photocatalytic process was attentively investigated through the characterization of reactive radicals, the stability and reusability of the photocatalyst, also the effect of operational parameters such as H2O2 dosage, solution pH and initial dye concentration. This work demonstrates the first example of facilitating photo‐Fenton‐like excitation of H2O2 via phosphonate based mixed metal organic frameworks as photocatalysts and explained a new opportunity for solar‐induced AOP environmental remediation and protection.
Effect of electron‐beam irradiation followed by annealing on the physical properties of poly(vinyl alcohol)–chitosan blend films at different weight ratios
Authors: Jahanabadi Robabe , Sheikh Nasrin , Mahdavi Hamid , Bagheri Rouhollah 
Published: April 2019

ABSTRACTThe aim of this study was to examine the effect of electron‐beam irradiation followed by annealing on the physical properties of poly(vinyl alcohol) (PVA)–chitosan (CS) blend films. Solution‐cast films containing various ratios of polymers were exposed to irradiation doses of 26, 39, and 52 kGy at room temperature and then annealed at 100 °C. The results show that at all doses, with an increase in the weight ratio of CS, the gel content of the samples decreased, and the water absorption of the samples increased. The irradiation dose ranged from 26 to 39 kGy; this led to an increased gel content and a decreased degree of swelling in the samples. However, at 52 kGy, an increase in the amount of swelling was observed. X‐ray diffraction analysis and scanning electronic microscopy images of the samples revealed that the increase in the irradiation dose reduced the crystallinity and increased the surface heterogeneity, respectively. The tensile strength of the blends decreased with decreasing PVA–CS weight ratio. This property of the samples increased with dose from 26 to 39 kGy and decreased at 52 kGy. The elongation at break of the samples decreased with both an increase in the irradiation dose and a decrease in the CS content. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47820.
Oil resistance and low‐temperature characteristics of plasticized nitrile butadiene rubber compounds
Authors: Kim Do Young , Kim Gi Hong , Nam Gi Myeong , Kang Dong Gug , Seo Kwan Ho 
Published: April 2019

ABSTRACTThe mechanical properties and oil resistance of nitrile butadiene rubber as an automotive material are investigated under low‐temperature conditions. We discuss the effects of various plasticizers, such as dioctyl adipate, adipic acid ester, polyether ester, and adipic acid polyester. The mechanical properties after thermal oxidation aging, as well as oil resistance and low‐temperature characteristics of the compounds, are measured using a moving die rheometer, universal testing machine, differential scanning calorimeter, low‐temperature retraction tester, and gehman torsional stiffness tester. We focus on how the oil resistance and low‐temperature characteristics are affected by the plasticizer type and plasticizer content. The results demonstrate that nitrile butadiene rubber compounds are affected by the low molecular weight and viscosity of the plasticizer. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47851.
Methyl ketone production by Pseudomonas putida is enhanced by plant‐derived amino acids
Authors: Dong Jie , Chen Yan , Benites Veronica Teixeira , Baidoo Edward E.K. , Petzold Christopher J. , Beller Harry R. , Eudes Aymerick , Scheller Henrik V. , Adams Paul D. , Mukhopadhyay Aindrila , Simmons Blake A. , Singer Steven W. 
Published: April 2019

AbstractPlants are an attractive sourceof renewable carbon for conversion to biofuels and bio‐based chemicals. Conversion strategies often use a fraction of the biomass, focusing on sugars from cellulose and hemicellulose. Strategies that use plant components, such as aromatics and amino acids, may improve the efficiency of biomass conversion. Pseudomonas putida is a promising host for its ability to metabolize a wide variety of organic compounds. P. putida was engineered to produce methyl ketones, which are promising diesel blendstocks and potential platform chemicals, from glucose and lignin‐related aromatics. Unexpectedly, P. putida methyl ketone production using Arabidopsis thaliana hydrolysates was enhanced 2–5‐fold compared with sugar controls derived from engineered plants that overproduce lignin‐related aromatics. This enhancement was more pronounced (~seven‐fold increase) with hydrolysates from nonengineered switchgrass. Proteomic analysis of the methyl ketone‐producing P. putida suggested that plant‐derived amino acids may be the source of this enhancement. Mass spectrometry‐based measurements of plant‐derived amino acids demonstrated a high correlation between methyl ketone production and amino acid concentration in plant hydrolysates. Amendment of glucose‐containing minimal media with a defined mixture of amino acids similar to those found in the hydrolysates studied led to a nine‐fold increase in methyl ketone titer (1.1 g/L).
A validated RP‐HPLC method for the evaluation of the influence of grapefruit juice on liver S9 activation of sacubitril
Authors: Moussa Bahia Abbas , Hashem Hanaa M.A. , Mahrouse Marianne Alphonse , Tarek Mahmoud Sally 
Published: April 2019

AbstractGrapefruit juice inhibits esterase enzyme. Therefore, a possible interaction with ester prodrugs should be taken into consideration. In this study, the influence of grapefruit juice on sacubitril (SAC) rat liver S9 activation by esterase enzyme was evaluated. An RP‐HPLC method was developed and validated for estimation of SAC in rat liver S9 fraction using a C18 Cyano column as stationary phase and acetonitrile–sodium di‐hydrogen phosphate buffer (0.02 m, pH 4 adjusted by o‐phosphoric acid, 40:60, v/v), as mobile phase at a flow rate of 1 mL/min and UV detection at 254 nm. The method was successfully applied to an in vitro study in which SAC was incubated with rat liver S9 fraction prepared from rats that had previously ingested grapefruit juice for a week. The calculated SAC concentration after incubation was compared with that of SAC incubated with rat liver S9 fraction from the rat control group. The statistical significance between the results of test and control incubation sets was assessed. In conclusion, the current study demonstrated that grapefruit juice decreased SAC hydrolysis, hence delaying its activation to sacubitrilat (active form) in gut lumen. Based on this food–drug interaction, it may be required that grapefruit juice should be consumed with caution in patients receiving SAC.
What is hindering change? Anticipating the barriers to the adoption of enzyme‐based textile processing in a developing country
Authors: Rahman Mahfuzur , Billah Md Morsaline , Hack‐Polay Dieu 
Published: April 2019

AbstractThe study aimed to examine the barriers to embracing enzymatic processing in the garment industry in a developing country. We used the case of Bangladesh, which has the largest garment sector in the world. The research used semistructured interviews with 10 high‐profile figures in the industry, comprising scientists, manufacturers, enzyme traders, and policymakers. We found economic, sociocultural, informational, and policy‐related barriers to the adoption of enzymatic processing. Attending to each element would benefit manufacturers primarily; this will help identify its strengths and weaknesses to ensure the effective implementation of enzymatic textile processing to obtain optimum results. The study also found that manufacturers' desire to help improve environmental performance is a factor, which could motivate them in adopting green manufacturing innovation. It is expected that regulatory frameworks that encourage innovation—particularly from high social responsiveness and compliances as well as economic and financial incentives—would motivate manufacturers to develop sustainable environmental management strategies that enhance their ability to compete in global markets.
Democratizing health insurance services; accelerating social inclusion through technology policy of health insurance firms
Authors: Nayak Bishwajit , Bhattacharyya Som Sekhar , Krishnamoorthy Bala 
Published: April 2019

AbstractTechnology plays an important role in reducing inequalities in health care delivery and enhancing quality of life. Health insurance firms require a potent technology policy to understand social determinants of health insurance that can lead to more innovative approaches to social inclusivity initiatives. This paper explicates critical factors of technology policy of health insurance firms that can contribute to better social inclusion and move towards universal health care. Through structured survey questionnaire, data were collected from 125 senior health insurance executives from India for identifying factors important for technology policy. A technology policy scale comprising six distinct factors is developed for health insurance firms using exploratory factor analysis. The factors are “organizational technology strategy,” “technology value drivers,” “technology utilization,” “firm agility in technology,” “firm technology capabilities,” and “customer focus through technology.” The factors identified in this study can be utilized and integrated with enabling technologies such as machine learning, internet of things, big data analytics, and digital phenotyping for creation of electronic health records that are critical for risk management of health insurance firms. This would help to promote healthy lifestyles and disease prevention strategies to strengthen universal health care for society. This paper looks at the factors that are essential in framing a technology policy for the health insurance sector. It provides reasons on how the factors contribute in the evolving health insurance field and can increase the rate of social inclusion for health care. And, finally, it helps in distinguishing how technology requirements and utilization in health insurance is different from other businesses.
Hybrid approach to ventricular septal defect enlargement
Authors: Patel Neil D. , Justino Henri , Ing Frank F. 
Published: April 2019

AbstractThe need for creation or enlargement of a ventricular septal defect (VSD) is a rare occurrence. It is most frequently required in patients with double‐outlet right ventricle who develop restriction of a remote muscular VSD or obstruction of a perimembranous VSD secondary to atrioventricular (AV) valve attachments to the interventricular septum. Surgical and transcatheter options for VSD creation or enlargement are associated with several risks including heart block, AV valve injury, and perforation. We report the first description of a hybrid approach to VSD creation and enlargement in two patients.
Influence of Solvents on Solution‐Mediated Polymorphic Transformation of the Polymorphs of L‐Histidine
Authors: Wantha Lek , Punmalee Neeranuch , Flood Adrian E. 
Published: April 2019

AbstractSolution‐mediated polymorphic transformation (SMPT) of the metastable polymorph B of L‐histidine (L‐his) into the stable polymorph A in water‐antisolvent solutions was performed. Methanol, acetone, and acetonitrile served as antisolvents. The SMPT was studied via nucleated batch antisolvent crystallization process by determining the change of the fraction of the stable polymorph A of L‐his in the crystal phase with time during the crystallization process. The fraction of the stable polymorph A of L‐his was assessed offline by Raman spectroscopy. The transformation time depended on the fractions of form A obtained at the initial stage of crystallization. The transformation rate of the metastable polymorph B into the stable polymorph A at lower antisolvent volume fraction was faster than at higher antisolvent volume fraction. The transformation time of polymorph B into polymorph A in water‐acetonitrile solution was the shortest compared to the other solutions.
Kinetic Control of a Self‐Assembly Pathway towards Hidden Chiral Microcoils
Authors: Guo Yongxian , Liu Yin , Gong Yanjun , Xiong Wei , Zhang Chuang , Zhao Jincai , Che Yanke 
Published: April 2019

AbstractManipulating the self‐assembly pathway is essentially important in the supramolecular synthesis of organic nano‐ and microarchitectures. Herein, we design a series of photoisomerizable chiral molecules, and realize precise control over pathway complexity with external light stimuli. The hidden single‐handed microcoils, rather than the straight microribbons through spontaneous assembly, are obtained through a kinetically controlled pathway. The competition between molecular interactions in metastable photostationary intermediates gives rise to a variety of molecular packing and thereby the possibility of chirality transfer from molecules to supramolecular assemblies.
A Highly Luminescent Tetrahydrocurcumin IrIII Complex with Remarkable Photoactivated Anticancer Activity
Authors: Colombo Alessia , Fontani Mattia , Dragonetti Claudia , Roberto Dominique , Williams J. A. Gareth , Scotto di Perrotolo Rossella , Casagrande Francesca , Barozzi Sara , Polo Simona 
Published: April 2019

AbstractCurcumin has chemopreventative properties against a variety of tumours, but has poor bioavailability. Here, two new bis‐cyclometallated iridium(III) complexes have been prepared, featuring the natural product curcumin (CUR) or its reduced form, tetrahydrocurcumin (THC), as bidentate, anionic O O‐binding ligands. The iridium THC complex is highly luminescent in deoxygenated solution and efficiently generates singlet oxygen under aerated conditions, whereas in the CUR analogue, other non‐radiative decay pathways are competitive. The complexes are rapidly taken up by a variety of human tumour cell lines from solutions of micromolar concentration. They show negligible cytotoxicity in the absence of irradiation. When briefly irradiated with visible light, Ir‐THC becomes highly phototoxic, inducing rapid apoptosis within 2 h. The results show the high potential of such complexes as sensitizers in photodynamic therapy (PDT).
Radical Cation Diels‐Alder Reactions of Non‐Conjugated Alkenes as Dienophiles by Electrocatalysis
Authors: Ozaki Atsushi , Yamaguchi Yusuke , Okada Yohei , Chiba Kazuhiro 
Published: April 2019

Summary of main observation and conclusionRadical cation Diels‐Alder reactions provide a powerful method for the construction of six‐membered ring systems between both electron‐rich dienes and dienophiles. However, the most recent examples of this class have been limited to β‐methylstyrenes as dienophiles; the use of non‐conjugated alkenes remains challenging. The present study describes the serendipitous development of novel radical cation Diels‐Alder reactions by electrocatalysis that use non‐conjugated alkenes as dienophiles. The key to successful transformation involves highly substituted cyclohexenyl radical cations that are stable enough to be reduced by intermolecular single electron transfer.
Aryl and Arylalkyl Substituted 3‐Hydroxypyridin‐2(1H)‐ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease
Authors: Sagong Hye Yeon , Bauman Joseph D. , Nogales Aitor , Martínez‐Sobrido Luis , Arnold Eddy , LaVoie Edmond J. 
Published: April 2019

AbstractSeasonal influenza infections are associated with an estimated 250–500 000 deaths annually. Resistance to the antiviral M2 ion‐channel inhibitors has largely invalidated their clinical utility. Resistance to neuraminidase inhibitors has also been observed in several influenza A virus (IAV) strains. These data have prompted research on inhibitors that target the cap‐snatching endonuclease activity of the polymerase acidic protein (PA). Baloxavir marboxil (Xofluza®), recently approved for clinical use, inhibits cap‐snatching endonuclease. Resistance to Xofluza® has been reported in both in vitro systems and in the clinic. An X‐ray crystallographic screening campaign of a fragment library targeting IAV endonuclease identified 5‐chloro‐3‐hydroxypyridin‐2(1H)‐one as a bimetal chelating agent at the active site. We have reported the structure–activity relationships for 3‐hydroxypyridin‐2(1H)‐ones and 3‐hydroxyquinolin‐2(1H)‐ones as endonuclease inhibitors. These studies identified two distinct binding modes associated with inhibition of this enzyme that are influenced by the presence of substituents at the 5‐ and 6‐positions of 3‐hydroxypyridin‐2(1H)‐ones. Herein we report the structure–activity relationships associated with various para‐substituted 5‐phenyl derivatives of 6‐(p‐fluorophenyl)‐3‐hydroxypyridin‐2(1H)‐ones and the effect of using naphthyl, benzyl, and naphthylmethyl groups as alternatives to the p‐fluorophenyl substituent on their activity as endonuclease inhibitors.
Inotuzumab ozogamicin in combination with low‐intensity chemotherapy (mini‐HCVD) with or without blinatumomab versus standard intensive chemotherapy (HCVAD) as frontline therapy for older patients with Philadelphia chromosome‐negative acute lymphoblastic leukemia: A propensity score analysis
Authors: Jabbour Elias J. , Sasaki Koji , Ravandi Farhad , Short Nicholas J. , Garcia‐Manero Guillermo , Daver Naval , Kadia Tapan , Konopleva Marina , Jain Nitin , Cortes Jorge , Issa Ghayas C. , Jacob Jovitta , Kwari Monica , Thompson Philip , Garris Rebecca , Pemmaraju Naveen , Yilmaz Musa , O’Brien Susan M. , Kantarjian Hagop M. 
Published: April 2019

BackgroundThe outcome of older patients with newly diagnosed, Philadelphia chromosome (Ph)‐negative acute lymphoblastic leukemia (ALL) is poor. The combination of targeted therapy with low‐intensity chemotherapy is safe and effective. The objective of the current analysis was to compare the outcome of patients who received a combination of inotuzumab ozogamicin plus low‐intensity chemotherapy (mini–hyperfractionated cyclophosphamide, vincristine, and dexamethasone [mini‐HCVD]) with or without blinatumomab versus the outcome of those who received the standard, intensive, hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (HCVAD) regimen.MethodsThe authors analyzed 135 older patients with newly diagnosed, Ph‐negative ALL who were treated prospectively with standard HCVAD (n = 77) or with the combination of inotuzumab ozogamicin plus mini‐HCVD with or without blinatumomab (n = 58). A propensity score analysis was conducted using 1:1 matching using the nearest neighbor matching method.ResultsPropensity score matching identified 38 patients in each cohort. The antibody plus low‐intensity chemotherapy combination induced higher response rates (98% vs 88%), with lower rates of early death (0% vs 8%) and lower rates of death in complete remission (5% vs 17%). With propensity score matching, the 3‐year event‐free survival rates for patients who received HCVAD and those who received the combination of inotuzumab ozogamicin plus mini‐HCVD with or without blinatumomab were 34% and 64%, respectively (P = .003), and the 3‐year overall survival rates were 34% and 63%, respectively (P = .004). By multivariate analysis, age (P = .019; hazard ratio, 1.045) and the combination of inotuzumab plus mini‐HCVD with or without blinatumomab (P = .020; hazard ratio, 0.550) were identified as independent prognostic factors for survival.ConclusionsThe combination of inotuzumab ozogamicin plus mini‐HCVD with or without blinatumomab is safe and effective in older patients with newly diagnosed, Ph‐negative ALL and confers a better outcome compared with standard HCVAD chemotherapy.
Complexing‐Coprecipitation Method to Synthesize Catalysts of Cobalt, Nitrogen‐Doped Carbon, and CeO2 Nanosheets for Highly Efficient Oxygen Reduction
Authors: Wang Xiaoqing , Xu Jijian , Wu Zongxiao , Zhi Mingjia , Hong Zhanglian , Huang Fuqiang 
Published: April 2019

AbstractThe oxygen reduction reaction (ORR) is the key cathode reaction in renewable‐energy technologies. Developing highly efficient, low‐cost, methanol‐tolerant and durable ORR catalysts is highly needed. In this research, we reported a simple complexing‐coprecipitation method to synthesize CeO2 nanosheets encapsulated by a nitrogen‐doped carbon (NC) layer with uniformly dispersed Co nanoparticles catalysts on the surface. In particular, the 0.5Co‐NC‐CeO2 sample exhibits high ORR catalytic activity with an onset potential of 875 mV (vs. RHE), a diffusion‐limited current density of 4.72 mA/cm2 and a positive half‐wave potential of 817 mV (vs RHE), while 20% Pt/C presents an onset potential of 934 mV (vs. RHE), a diffusion limited current density of 5.8 mA/cm2 and half‐wave potential of 850 mV (vs. RHE). In addition, the catalyst 0.5Co‐NC‐CeO2 also possesses a robust durability, that is the half‐wave potential exhibits a negative shift of only 17 mV after 1000 cycles. The enhanced ORR performance can be attributed to the synergistic effect among Co, the nitrogen‐doped carbon layer and CeO2. The results demonstrated here have implications in designing non‐Pt ORR catalysts.
Rapid Quantification of NETs In Vitro and in Whole Blood Samples by Imaging Flow Cytometry
Authors: Lelliott Patrick M. , Momota Masatoshi , Lee Michelle S.J. , Kuroda Etsushi , Iijima Norifumi , Ishii Ken J. , Coban Cevayir 
Published: April 2019

AbstractNeutrophil extracellular trap (NET) formation involves the release of DNA outside the cell to neutralize pathogens. Techniques such as live microscopy, flow cytometry, and intravital imaging allow the characterization of NETs, but these either cannot be applied in vivo, lack specificity or require invasive procedures. We developed an automated analysis method to rapidly acquire and characterize cells as NETs or NET precursors, as opposed to cells undergoing other forms of cell death, using imaging flow cytometry. NETs were maintained in solution using a novel three‐dimensional cell culture system in which cells are suspended at the interface of two liquids of different density. Critically, we identify NETs using an image analysis algorithm based on morphological data showing the extrusion of DNA beyond the cell boundaries. In vitro, we used this technique to demonstrate different requirements for NET formation in human and mouse neutrophils. We also measured NETs in whole blood during infection of mice with the malaria parasite Plasmodium yoelii. We expect this technique will provide a valuable approach to better understand the process of NET formation and its importance in disease. © 2019 International Society for Advancement of Cytometry