bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of proton MR spectroscopy in the differentiation of borderline from malignant epithelial ovarian tumors: A preliminary study
Authors: Ma Feng Hua , Li Yong Ai , Liu Jia , Li Hai Ming , Zhang Guo Fu , Qiang Jin Wei 
Published: October 2018

BackgroundDue to the overlapping imaging appearances between borderline and malignant epithelial ovarian tumors (EOTs), borderline EOTs often represent a diagnostic challenge on conventional MRI. Proton magnetic resonance spectroscopy (1H‐MRS) might have potential to differentiate borderline from malignant tumors.PurposeTo investigate the ability of 1H‐MRS to differentiate borderline from malignant EOTs.Study TypeProspective.PopulationIn all, 278 patients with adnexal masses.Field Strength/Sequence1.5 T Siemens Avanto MRI system and 1H‐MRS using a point‐resolved spectroscopy sequence (PRESS).AssessmentResonance peak integrals of the most common metabolites were analyzed and compared between the two groups.Statistical TestsThe ratios of metabolites between borderline and malignant EOTs were compared with the Mann–Whitney U‐test. A receiver operating characteristic (ROC) curve was used to determine their differential diagnosis performances.ResultsIn the solid components of borderline and malignant EOTs, the mean Cho/Cr, NAA/Cr, and NAA/Cho ratios were 4.4 ± 1.1 and 9.9 ± 2.8; 10.4 ± 3.0 and 2.2 ± 1.0; and 2.4 ± 0.7 and 0.3 ± 0.1, respectively (all P < 0.001). The sensitivity, specificity, and area under the curve (AUC) were 91%, 100%, and 0.98 for the Cho/Cr ratio; 100%, 98%, and 0.99 for the NAA/Cr ratio; and 100%, 100%, and 1.00 for the NAA/Cho ratio, respectively. In the cystic components, the mean Cho/Cr, NAA/Cr, and NAA/Cho ratios were 3.2 ± 0.8 and 5.1 ± 1.2; 9.1 ± 3.4 and 2.3 ± 1.4; and 2.9 ± 1.2 and 0.5 ± 0.4, respectively (all P < 0.001). The sensitivity, specificity, and AUC were 84%, 82%, and 0.89 for the Cho/Cr ratio; 94%, 97%, and 0.99 for the NAA/Cr ratio; and 94%, 97%, and 0.99 for the NAA/Cho ratio, respectively.Data ConclusionThe NAA/Cho ratio is a reliable biomarker for differentiating borderline from malignant EOTs.Level of Evidence: 2Technical Efficacy: Stage 3J. Magn. Reson. Imaging 2019;49:1684–1693.
Kinetic modeling of high‐pressure induced inactivation of polyphenol oxidase in sugarcane juice (Saccharum officinarum)
Authors: Sreedevi Pandraju , Jayachandran Lakshmi E , Rao Pavuluri Srinivasa 
Published: October 2018

AbstractBACKGROUNDPolyphenol oxidase (PPO) is the main enzyme in sugarcane juice associated with rapid browning and degradation of organoleptic properties. High‐pressure processing (HPP) (300–600 MPa) of sugarcane juice in combination with moderate temperatures (30–60 °C) for different processing times (10–25 min) has shown promising results in minimizing PPO activity while preserving the juice's freshness.RESULTSA maximum PPO inactivation of 98% was achieved at 600 MPa/60 °C/25 min, while the corresponding value for thermal treatment at 0.1 MPa/60 °C was only 66%. The nonlinearity in the inactivation data was well described by the Weibull distribution model with a high adjusted R2 and reduced χ2 values at all levels of pressure and temperature. The PPO inactivation data were fitted at shape parameter, β = 1 (log linear) and β ≠ 1. A refitted Weibull model was used to predict kinetic parameters such as the inactivation rate constants (k), activation energy (Ea) and activation volume (Va), which govern PPO inactivation in HPP‐treated sugarcane juice. A secondary kinetic model was formulated to predict the k values as a function of pressure (P) and temperature (T), incorporating Ea and Va.CONCLUSIONSCombined high‐pressure and temperature processing has been considered a reliable alternative to conventional heat treatment for inhibiting PPO activity in sugarcane juice. While the isothermal inactivation of PPO followed first‐order kinetics, inclusion of high pressure resulted in a strong deviation from log linear kinetics. Identification of suitable kinetic models describing these inactivation processes is expected to aid product development and process control of high‐pressure processed sugarcane juice. © 2018 Society of Chemical Industry
Safety and efficacy of Early injection laryngoplasty in pediatric patients
Authors: Bertelsen Caitlin , Jacobson Lia , Osterbauer Beth , Hochstim Christian 
Published: October 2018

ObjectiveThe major morbidity of unilateral vocal fold immobility (UVFI) in children is due to aspiration. Early injection laryngoplasty (IL) can decrease aspiration risk; however, this has not been well studied in pediatric otolaryngology. This study examines safety and efficacy of early IL in children.MethodsRetrospective review of pediatric patients undergoing IL with any injectate between 2006 and 2017 within 6 months of onset of UVFI. Outcomes included diet pre‐ and postprocedure, incidence of aspiration‐related sequelae, and adverse events.ResultsSeventeen patients met eligibility criteria. Ten (58.8%) were males. Median age was 8 months (interquartile range, 2 months–11.5 years). All patients had prior surgeries; the largest subgroup (11 patients, 64.7%) had UVFI after repair of a congenital cardiac defect. Other causes included thyroidectomy, high vagal injury, and prolonged intubation.Sixteen patients underwent swallowing evaluation prior to IL and 14 patients required dietary modifications due to aspiration risk. Consistency and/or volume of oral intake improved after IL in 10 (71.4%) of them. Five patients underwent gastrostomy tube placement for significant oromotor incoordination. Children with congenital cardiac defects had more previous surgeries (3.0 ± 0.4 vs. 1.2 ± 0.2, P = .006) and were more likely to require G‐tube placement due to poor feeding despite IL (45% vs. 0%, P = .05). No patients experienced adverse events due to IL; in particular, none experienced airway symptoms requiring intubation.ConclusionEarly IL in pediatric patients with UVFI is safe and can reduce aspiration and improve oral intake. Future studies should elucidate patient subgroups most likely to benefit from this intervention.Level of Evidence4Laryngoscope, 129:1699–1705, 2019
Thermoresponsive Three‐Stage Optical Modulation of a Self‐Healing Composite Hydrogel
Authors: Wang Haihuan , Zhan Jianghao , Xiao Kechen , Luo Feng , Li Jiehua , Tan Hong 
Published: October 2018

AbstractA self‐healing composite hydrogel with thermoresponsive three‐stage optical adjustment (opaque‐transparent‐translucent) is achieved by combining polyampholyte hydrogel (PAH) with a small amount of poly(N‐isopropylacrylamide) (PNIPAM) nanogels. The PAH has an upper critical solution temperature to dominate the initial optical stage of reversible opaque‐transparent transition and also offers its self‐healing properties via reversible ionic bonds. Meanwhile, the PNIPAM shows a lower critical solution temperature by hydrophilic‐hydrophobic phase transition and synergistic clustering of PAH, which controls the subsequent optical stage of reversible transparent‐translucent transition. Therefore, the PAH/PNIPAM composite hydrogel shows a reversible three‐stage optical modulation by controlling temperature from low (<15 °C) to medium (15–30 °C) to high (>30 °C) via double phase transition behavior of PAH/PNIPAM. Through different analytical methods, the synergistic thermoreposensive effects of PNIPAM nanogels and the bulk PAH are demonstrated. Finally, a prototype of a smart window is designed to demonstrate one of its potential applications.
Universal and complete sets in martingale theory
Authors: Lecomte Dominique , Zelený Miroslav 
Published: October 2018

AbstractThe Doob convergence theorem implies that the set of divergence of any martingale has measure zero. We prove that, conversely, any subset of the Cantor space with Lebesgue‐measure zero can be represented as the set of divergence of some martingale. In fact, this is effective and uniform. A consequence of this is that the set of everywhere converging martingales is ‐complete, in a uniform way. We derive from this some universal and complete sets for the whole projective hierarchy, via a general method. We provide some other complete sets for the classes and in the theory of martingales.
New combinatorial principle on singular cardinals and normal ideals
Authors: Usuba Toshimichi 
Published: October 2018

AbstractWe introduce a new combinatorial principle on singular cardinals. This principle allows us to take a kind of a diagonal intersection of more than λ many measure one sets of certain normal ideals over. Under the principle, we give various characterizations of the saturation property of normal ideals over. We also consider Chang's type transfer properties under the principle, and, when λ is Jónsson, we prove that every normal ideal overwithmeasure one cannot have strong properties.
Existence and asymptotic behaviour for the time‐fractional Keller–Segel model for chemotaxis
Authors: Azevedo Joelma , Cuevas Claudio , Henriquez Erwin 
Published: October 2018

AbstractOne of the most important systems for understanding chemotactic aggregation is the Keller–Segel system. We consider the time‐fractional Keller–Segel system of order . We prove an existence result with small initial data in a class of Besov–Morrey spaces. Self‐similar solutions are obtained and we also show an asymptotic behaviour result.
Identification of a TLR2 Inhibiting Wheat Hydrolysate
Authors: Kiewiet Mensiena B. G. , Dekkers Renske , van Gool Martine P. , Ulfman Laurien H. , Groeneveld Andre , Faas Marijke M. , de Vos Paul 
Published: October 2018

ScopeWheat hydrolysates are used in medical nutrition to provide undernourished patients a readily digestible protein source, for instance to recover from chemotherapy‐induced intestinal mucosal inflammation. Since many hydrolysates of different sources can modulate the immune system, likely via Toll‐like receptors (TLRs), it is hypothesized that also wheat hydrolysates might interact with TLR signaling, which could be a way to prevent intestinal inflammation and damage.Methods and resultsThe capacity of three wheat hydrolysates to modulate immunity by interfering with TLR signaling is determined. All wheat hydrolysates have TLR modulating effects but only one has strong TLR2 inhibiting effects, attenuating both TLR2/1 and TLR2/6 signaling in a reporter cell system. This is likely induced by direct TLR2‐ectodomain binding, as confirmed by ELISA. Furthermore, this TLR2 blocking hydrolysate reduces IL‐6 production in human dendritic cells. Application of reversed‐phase–ultra HPLC combined with MS reveals that the presence of peptide WQIPEQSR is associated with the observed TLR2 inhibiting capacity.ConclusionThe study demonstrates TLR2‐inhibiting capacities of a wheat hydrolysate. The findings provide a good start for further research to investigate whether this hydrolysate might contribute to the management of intestinal mucosal inflammation in cancer patients receiving chemotherapy.
A dual‐band implantable antenna with wide‐band characteristics at MICS and ISM bands
Authors: Basir A. , Bouazizi A. , Zada M. , Iqbal A. , Ullah S. , Naeem U. 
Published: October 2018

AbstractThis letter presents the design of a miniaturized dual‐band spiral antenna for biomedical applications. The recommended antenna covers both the Medical Implant Communication Service MICS (402‐405 MHz) as well as the Industrial Scientific Medical ISM (2.4‐2.48 GHz) band. Different size reduction techniques have been applied to downsize the antenna and the latter achieved a compact size of 14 × 17 × 0.25 mm3. For validation purpose, measurements were conducted in the saline solution having properties comparable to muscles. The structure achieves very good measured peak gain values of −33 dBi and − 16 dBi at 403 MHz and 2.45 GHz, respectively. The proposed antenna has a wide‐band characteristic at both bands, which is the key for an antenna to be implanted into different tissue environments. Both the simulated and measured impedance bandwidths are sufficiently covering the intended bands. A decent agreement is observed between simulated and measured results.
Fully automatic segmentation of 4D MRI for cardiac functional measurements
Authors: Wang Yan , Zhang Yue , Xuan Wanling , Kao Evan , Cao Peng , Tian Bing , Ordovas Karen , Saloner David , Liu Jing 
Published: October 2018

PurposeSegmentation of cardiac medical images, an important step in measuring cardiac function, is usually performed either manually or semiautomatically. Fully automatic segmentation of the left ventricle (LV), the right ventricle (RV) as well as the myocardium of three‐dimensional (3D) magnetic resonance (MR) images throughout the entire cardiac cycle (four‐dimensional, 4D), remains challenging. This study proposes a deformable‐based segmentation methodology for efficiently segmenting 4D (3D + t) cardiac MR images.MethodsThe proposed methodology first used the Hough transform and the local Gaussian distribution method (LGD) to segment the LV endocardial contours from cardiac MR images. Following this, a novel level set‐based shape prior method was applied to generate the LV epicardial contours and the RV boundary.ResultsThis automatic image segmentation approach has been applied to studies on 17 subjects. The results demonstrated that the proposed method was efficient compared to manual segmentation, achieving a segmentation accuracy with average Dice values of 88.62 ± 5.47%, 87.35 ± 7.26%, and 82.63 ± 6.22% for the LV endocardial, LV epicardial, and RV contours, respectively.ConclusionsWe have presented a method for accurate LV and RV segmentation. Compared to three existing methods, the proposed method can successfully segment the LV and yield the highest Dice value. This makes it an option for clinical assessment of the volume, size, and thickness of the ventricles.
Interpersonal touch interventions for patients in intensive care: A design‐oriented realist review
Authors: Harris Sansha J. , Papathanassoglou Elizabeth D. E. , Gee Melanie , Hampshaw Susan M. , Lindgren Lenita , Haywood Annette 
Published: October 2018

AbstractAimTo develop a theoretical framework to inform the design of interpersonal touch interventions intended to reduce stress in adult intensive care unit patients.DesignRealist review with an intervention design‐oriented approach.MethodsWe searched CINAHL, MEDLINE, EMBASE, CENTRAL, Web of Science and grey literature sources without date restrictions. Subject experts suggested additional articles. Evidence synthesis drew on diverse sources of literature and was conducted iteratively with theory testing. We consulted stakeholders to focus the review. We performed systematic searches to corroborate our developing theoretical framework.ResultsWe present a theoretical framework based around six intervention construction principles. Theory testing provided some evidence in favour of treatment repetition, dynamic over static touch and lightening sedation. A lack of empirical evidence was identified for construction principles relating to intensity and positive/negative evaluation of emotional experience, moderate pressure touch for sedated patients and intervention delivery by relatives versus healthcare practitioners.
Continuous‐Wave Line Laser for Large Area Material Refinement
Authors: Kühnapfel Sven , Harten Paul , Gall Stefan 
Published: October 2018

AbstractIn a constantly evolving laser industry, new and innovative applications of laser radiation are emerging – in scope as well as in numbers. While pulsed line‐shaped laser beams are already well established as mainstream manufacturing tools in the production of flat panel displays, continuous‐wave line beam processes are still in their infancy. Nevertheless, they have shown great potential in research & development laboratories as well as in pilot plants for various thermal material processing applications.
Understanding Aspheric Lenses
Authors: Adams Daniel , Ament Shelby 
Published: October 2018

AbstractAspheric lenses are an extremely powerful tool for improving the performance of optical systems whilst also reducing the number of elements and consequently size and weight. From medical equipment and microscopes to smart phones and autonomous vehicles, they are increasingly important across all optics‐enabled industries. An aspheric surface cannot be made in the same way as a spherical one, a range of sub‐aperture grinding and polishing techniques must be used to create a variable curvature. These methods create additional issues that need to be monitored and controlled to maximize the performance of an aspheric lens.
Using Diffractive Optical Elements
Authors: Katz Shlomit , Kaplan Natan , Grossinger Israel 
Published: October 2018

AbstractA diffractive optical element (DOE) uses thin micro‐structure patterns to alter the phase of the light that is propagated through it. Those micro‐structures, once properly designed, can manipulate the light to almost any desired intensity profile or shape. This technology enables many functions and light manipulations which are not feasible with standard refractive optics.
Laser Cutting, Positioning, and Joining in One Clamping
Authors: Liebhart Harald 
Published: October 2018

AbstractEquipping components which carry media with threaded bushings or fittings, replacing hydroformed components by deep‐drawn half‐shells, and building complex 3D assemblies from individual parts direct from the coil – these are the areas of application for CutFusion from Weil Engineering, the mechanical engineers from Müllheim, South Germany. CutFusion not only saves a great deal of handling time and effort, it also makes the manufacturing workflow much safer.
Thylakoid‐integrated recombinant Hcf106 participates in the chloroplast twin arginine transport system
Authors: Ma Qianqian , Fite Kristen , New Christopher Paul , Dabney‐Smith Carole 
Published: October 2018

AbstractThe chloroplast twin arginine transport (cpTat) system distinguishes itself as a protein transport pathway by translocating fully folded proteins, using the proton‐motive force (PMF) as the sole source of energy. The cpTat pathway is evolutionarily conserved with the Tat pathway found in the plasma membrane of many prokaryotes. The cpTat (Escherichia coli) system uses three proteins, Tha4 (TatA), Hcf106 (TatB), and cpTatC (TatC), to form a transient translocase allowing the passage of precursor proteins. Briefly, cpTatC and Hcf106, with Tha4, form the initial receptor complex responsible for precursor protein recognition and binding in an energy‐independent manner, while a separate pool of Tha4 assembles with the precursor‐bound receptor complex in the presence the PMF. Analysis by blue‐native polyacrylamide gel electrophoresis (BN‐PAGE) shows that the receptor complex, in the absence of precursor, migrates near 700 kDa and contains cpTatC and Hcf106 with little Tha4 remaining after detergent solubilization. To investigate the role that Hcf106 may play in receptor complex oligomerization and/or stability, systematic cysteine substitutions were made in positions from the N‐terminal transmembrane domain to the end of the predicted amphipathic helix of the protein. BN‐PAGE analysis allowed us to identify the locations of amino acids in Hcf106 that were critical for interacting with cpTatC. Oxidative cross‐linking allowed us to map interactions of the transmembrane domain and amphipathic helix region of Hcf106. In addition, we showed that in vitro expressed, integrated Hcf106 can interact with the precursor signal peptide domain and imported cpTatC, strongly suggesting that a subpopulation of the integrated Hcf106 is participating in competent cpTat complexes.
The Adrenal Lipid Droplet is a New Site for Steroid Hormone Metabolism
Authors: Yu Jinhai , Zhang Linqiang , Li Yunhai , Zhu Xiaotong , Xu Shimeng , Zhou Xiao‐Ming , Wang Haizhen , Zhang Hongchao , Liang Bin , Liu Pingsheng 
Published: October 2018

AbstractSteroid hormones play essential roles for living organisms. It has been long and well established that the endoplasmic reticulum (ER) and mitochondria are essential sites for steroid hormone biosynthesis because several steroidogenic enzymes are located in these organelles. The adrenal gland lipid droplet (LD) proteomes from human, macaque monkey, and rodent are analyzed, revealing that steroidogenic enzymes are also present in abundance on LDs. The enzymes found include 3β‐hydroxysteroid dehydrogenase (HSD3B) and estradiol 17β‐dehydrogenase 11 (HSD17B11). Analyses by Western blot and subcellular localization consistently demonstrate that HSD3B2 is localized on LDs. Furthermore, in vitro experiments confirm that the isolated LDs from HeLa cell stably expressing HSD3B2 or from rat adrenal glands have the capacity to convert pregnenolone to progesterone. Collectively, these data suggest that LDs may be important sites of steroid hormone metabolism. These findings may bring novel insights into the biosynthesis and metabolism of steroid hormones and the development of treatments for adrenal disorders.
Pharmacokinetics and safety of Enasidenib following single oral doses in Japanese and Caucasian subjects
Authors: Li Yan , Liu Liangang , Gomez Diana , Chen Jian , Tong Zeen , Palmisano Maria , Zhou Simon 
Published: October 2018

AbstractThe aim of this study was to assess and compare the pharmacokinetics (PK) and safety of Enasidenib in healthy adult male Japanese subjects to healthy adult male Caucasian subjects. This was a phase 1, single dose study to evaluate the PK and safety of Enasidenib in healthy adult male Japanese subjects relative to healthy adult male Caucasian subjects. A total of 62 subjects (31 Japanese and 31 Caucasian) were enrolled into three dose cohorts (single doses of 50 mg, 100 mg, or 300 mg Enasidenib). Blood samples for PK assessment were collected up to 672 hours postdose. Safety was evaluated throughout the study. In the present study, we found that PK exposures of Enasidenib and its metabolite AGI‐16903 for Caucasian and Japanese subjects were comparable at the 50, 100, and 300 mg dose levels, demonstrated by that the 90% confidence intervals (CIs) of geometric mean ratios for AUCs and Cmax between these two populations generally contained 100% from all three treatment cohorts. In conclusion, PK exposures of Enasidenib and its metabolite AGI‐16903 for Caucasians and Japanese subjects were comparable and Enasidenib was safe and well tolerated with no apparent differences between Japanese and Caucasian subjects when administered as single oral doses of 50 mg, 100 mg, and 300 mg.
On‐Water NiFe2O4 Nanoparticle‐Catalyzed One‐Pot Synthesis of Biofunctionalized Pyrimidine‐Thiazole Derivatives: In Silico Binding Affinity and In Vitro Anticancer Activity Studies
Authors: Sharma Archi , Gudala Satish , Ambati Srinivasa Rao , Mahapatra S. P. , Raza Asif , L. Aruna , Payra Soumen , Jha Anubhuti , Kumar Awanish , Penta Santhosh , Banerjee Subhash 
Published: October 2018

AbstractA series of novel integrated bio‐active pyrimidine‐thiazole derivatives have been efficiently synthesized via NiFe2O4‐NP‐catalyzed, one‐pot three component reactions in aqueous ethanol as green solvent. The synthesized compounds were screened against different cancer cell lines (A375, HeLa, and MCF‐7) and it was observed that thiazole derivatives exhibited good anticancer activity against A375 and MCF‐7 cancer cell line comparable to erlotinib. Compound 4 h displayed comparable anticancer activity against all the three cancer cell lines A375, HeLa and MCF‐7. The in silico molecular docking studies for all the newly synthesized compounds were shown good to excellent binding affinity for Hsp90 proteins. In ADME analysis, the best result for absorption and metabolism is shown by the compound 4e. While the excretory parameter is found to be the best for compound 4 h.