bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive Sampling for Spatial Capture-Recapture: An efficient sampling scheme for rare or patchily distributed species
Authors: Wong Alec , Fuller Angela , Royle J. Andrew 
Published: June 2018

AbstractRare species present challenges to data collection, particularly when the species is spatially clustered over large areas, such that the encounter frequency of the organism is low. Sampling where the organism is absent consumes resources, and offers relatively low-quality information which are often difficult to model using standard statistical methods. In adaptive sampling, a probabilistic sampling method is employed first, and additional effort is allocated in the vicinity of sites where some measured index variable - assumed to be proportional to local population size - exceeds an a priori threshold. We applied this principle to the spatial capture-recapture (SCR) analytical framework in a Bayesian hierarchical model incorporating capture-recapture (CR) and index information from unsampled sites to estimate density. We assessed the adaptively sampled SCR model (AS-SCR) by simulating CR data and compared performance with a standard SCR baseline (F-SCR), adaptive SCR discarding index information (AS-SCR–), and standard SCR applied at a simple random sample of sites. Under AS-SCR, we observed minimal bias and comparable variance with respect to parameter estimates provided by the standard F-SCR model and sampling implementation, but with substantially reduced effort and significant cost saving potential. This represents the first application of adaptive sampling to SCR.
DataRemix: a universal data transformation for optimal inference from gene expression datasets
Authors: Mao Weiguang , Hausler Ryan , Chikina Maria 
Published: June 2018

AbstractMotivationRNAseq technology provides unprecedented power in the assesment of the transcription abundance and can be used to perform a variety of downstream tasks such as inference of gene-correlation network and eQTL discovery. However, raw gene expression values have to be normalized for nuisance biological variation and technical covariates, and different normalization strategies can lead to dramatically different results in the downstream study.ResultsWe describe a generalization of SVD-based reconstruction for which the common techniques of whitening, rank-k approximation, and removing the top k principle components are special cases. Our simple three-parameter transformation, DataRemix, can be tuned to reweight the contribution of hidden factors and reveal otherwise hidden biological signals. In particular, we demonstrate that the method can effectively prioritize biological signals over noise without leveraging external dataset-specific knowledge, and can outperform normalization methods that make explicit use of known technical factors. We also show that DataRemix can be efficiently optimized via Thompson Sampling approach, which makes it feasible for computationally expensive objectives such as eQTL analysis. Finally we reanalyze the Depression Gene Networks (DGN) dataset, and we highlight new trans-eQTL networks which were not reported in the initial study.AvailabilityDataRemix is an R package which is freely available at GitHub (https://github.com/wgmao/DataRemix).Contactmchikina@pitt.edu
Combined inhibition of apoptosis and necrosis promotes transient neuroprotection of retinal ganglion cells and partial-axon regeneration after optic nerve damage
Authors: Kayama Maki , Omura Kumiko , Murakami Yusuke , Reshef Edith , Thanos Aristomenis , Morizane Yuki , Giani Andrea , Nakazawa Toru , Miller Joan W. , Benowitz Larry , Vavvas Demetrios G. 
Published: June 2018

SUMMARYRetinal ganglion cell (RGC) death is the hallmark of glaucoma. Axonal injury is thought to precede RGC loss in glaucoma, and thus studies using an optic nerve (ON) crush model have been widely used to investigate mechanisms of cell death that are common to both conditions. Prior work has focused on the involvement of caspases in RGC death, but little is known about the contribution of other forms of cell death such as necrosis. In this study we show that receptor interacting protein (RIP) kinase-mediated necrosis normally plays a role in RGC death and acts in concert with caspase-dependent apoptosis. The expression of RIP3, a key activator of RIP1 kinase, as well as caspase activity, increased following ON injury. Caspase inhibition alone failed to provide substantial protection to injured RGCs and unexpectedly exacerbated necrosis. In contrast, pharmacologic or genetic inhibition of RIP kinases in combination with caspase blockade delayed both apoptotic and necrotic RGC death, although RGCs still continued to die. Furthermore, inhibition of RIP1 kinase promoted a moderate level of axon regeneration that was only minimal affected by caspase inhibition. In conclusion, multiple approaches are required for effective RGC death prevention and axonal regeneration. Further studies are needed to elucidate more effective long term strategies that can lead to sustained neuroprotection and regeneration.
Kunitz type protease inhibitor EgKI-1 from the canine tapeworm Echinococcus granulosus as a promising anti-cancer therapeutic
Authors: Ranasinghe Shiwanthi L , Boyle Glen M , Fischer Katja , Potriquet Jeremy , Mulvenna Jason P , McManus Donald P 
Published: June 2018

AbstractEgKI-1, a member of the Kunitz type protease inhibitor family, is highly expressed by the oncosphere of the canine tapeworm Echinococcus granulosus, the stage that is infectious to humans and ungulates, giving rise to a hydatid cyst localized to the liver and other organs. Larval protoscoleces, which develop within the hydatid cyst, have been shown to possess anti-cancer properties, although the precise molecules involved have not been identified. We show that recombinant EgKI-1 inhibits the growth and migration of a range of human cancers including breast, melanoma and cervical cancer cell lines in a dose-dependent manner in vitro without affecting normal cell growth. Furthermore, EgKI-1 treatment arrested the cancer cell growth by disrupting the cell cycle and induced apoptosis of cancer cells in vitro. An in vivo model of triple negative breast cancer (MDA-MB-231) in BALB/c nude mice showed significant tumor growth reduction in EgKI-1-treated mice compared with controls. These findings indicate that EgKI-1 shows promise for future development as an anti-cancer therapeutic.
The indirect effects of performance measurement system and organizational ambidexterity on performance
Authors: Severgnini Elizandra , Vieira Valter Afonso , Cardoza Galdamez Edwin Vladimir 
Published: June 2018

PurposePerformance measurement systems (PMSs) have long been used for monitoring and improving administrative performance. In parallel, organizational ambidexterity refers to firms that manage different organizational functions and various demands to generate performance. The purpose of this paper is to propose that three dimensions of PMS increase organizational ambidexterity and consequently they influence organizational performance. In this framework, organizational ambidexterity mediates the relationships between three dimensions of PMS and organizational performance.Design/methodology/approachThe data were collected through a structured questionnaire sent to Brazilian software companies. Owners, directors, project managers and responsible for company strategy answered the questionnaire. The final sample was 227 Brazilian software firms that answered according to their PMSs and organizational ambidexterity.FindingsThe results provide four main findings. First, the three dimensions of PMS, namely—attention focus, legitimization and strategic decision-making—influenced organizational ambidexterity. Second, organizational ambidexterity had a major effect on organizational performance. Third, organizational ambidexterity mediated the indirect effects of attention focus, legitimization and strategic decision-making on organizational performance. Fourth, exploration and exploitation—two dimensions of organizational ambidexterity—mediated the indirect effect of the abovementioned PMS dimensions on organizational performance.Research limitations/implicationsAlthough there are different dimensions of organizational ambidexterity, this paper is limited to two of the most used ones: exploitation and exploration. In addition, the results were limited to subjective—in contrast to objective—performance measures.Practical implicationsSoftware companies can use PMS for attention focus, legitimization of firm’s choices and strategic decision-making to increase their exploration and exploitation capabilities. Moreover, software companies can use strategic decision-making to control existing strategies and establish new strategies for legitimizing ambidextrous choices and thereby support their decision-making process.Originality/valueThe data showed that not only organizational ambidexterity mediates the effects of the three dimensions of PMS use on performance, but also exploration and exploitation.
Evaluation of hydrodynamic lubrication performance of textured surface from the perspective of skewness and kurtosis
Authors: He Xia , Liao Wenling , Wang Guorong , Zhong Lin , Li Mengyuan 
Published: June 2018

Purpose
The purpose of this study is to investigate the influence of texture on hydrodynamic lubrication performance of slide surface from the perspective of skewness and kurtosis.

Design/methodology/approach
Hydrodynamic lubrication theoretical model of textured surface was established based on two-dimensional Reynolds equation, and finite difference algorithm was used as the numerical approach in the paper. Skewness and kurtosis of surface were obtained by discrete calculation.

Findings
Numerical analysis results show that the influence law of texture types on skewness, kurtosis and hydrodynamic lubrication was the more negative skewness and higher kurtosis, the better hydrodynamic lubrication performance when texture cross section contour and geometric parameters were the same. Similarly, the same influence law of skewness, kurtosis and hydrodynamic lubrication performance by texture cross-section contour was observed. However, it was unable to evaluate the effect of texture angle on hydrodynamic lubrication performance of textured surface from the perspective of skewness and kurtosis.

Originality/value
This paper confirms the feasibility of evaluating influence of texture types and texture cross-section contour on hydrodynamic lubrication performance from the perspective of skewness and kurtosis and provides a way to optimize texture type and texture cross section.
Corporate Social Responsibility (CSR) communication patterns in an emerging market
Authors: El-Bassiouny Noha , Darrag Menatallah , Zahran Nada 
Published: June 2018

Purpose
The purpose of this paper is to explore the concept of Corporate Social Responsibility (CSR) communication. This paper specifically aims at introspecting into CSR communication patterns in the Egyptian context, where the top ten companies in the Egyptian Stock Exchange–Environmental, Social and Governance Index (EGX-ESG) are sampled.

Design/methodology/approach
The paper presents an exploratory study where content analysis of the communications of the ten top-listed companies in the ESG Index in Egypt was analyzed.

Findings
The results showed that most companies are using the “stakeholder information” strategy, with the “stakeholder involvement” strategy being the least used.

Research limitations/implications
The results are limited to the use of the content analysis method which is a qualitative methodology. Hence, the results should be generalized with caution.

Practical implications
CSR communication is crucial to the success of companies, regardless of business size, industry or culture. Several aspects of CSR communication, to this day, remain vague for academics and practitioners alike. Therefore, additional insights about the topic should be generated. The present work aids in the understanding of CSR communication as a facet of organizational change and a new trend in emerging markets.

Social implications
The current exploratory study sheds light on the topic of CSR communication in an important emerging market in transition, namely Egypt. The results of the communication strategies utilized by the top-listed companies can be generalized to other similar contexts.

Originality/value
The majority of the studies conducted on this particular topic took place in the USA and Europe; hence, few insights are provided about the concept in emerging markets.
Reinforcing innovation through transformational leadership: mediating role of job satisfaction
Authors: Al-edenat Malek 
Published: June 2018

PurposeThe purpose of this paper is to examine the direct role being played by transformational leadership (TL) dimensions in reinforcing product and service innovation. More particularly, the paper focusses on the role of job satisfaction (JS) as a mediator in this relationship.Design/methodology/approachA concurrent mixed methods technique was employed. The researcher surveyed 486 participants from three major telecoms companies that operate in Jordan to supply the society with mobile phones and internet services. In addition, 15 team leaders were interviewed for the same purpose.FindingsThe results of this paper support the positive direct impact of transformational leaders on both employees’ innovativeness and JS. In addition, JS was found to positively impact product and service innovation. Moreover, the results revealed that JS mediates the relationship between TL and innovation.Research limitations/implicationsLeaders are playing a direct and significant role in reinforcing product and service innovation in an interesting manner, especially through JS. Other styles of leadership, populations, and methods may create new perceptions in further research works.Practical implicationsThe findings in this paper indicate that practising superior level of TL behaviours enhances overall JS, which, as a result, reinforces product and service innovation within employees in the Jordanian telecom sector. Superior outputs are achieved through such styles both for the firm as a whole towards innovative products and services, and similarly, for individuals within teams who involve in further innovative team climate.Originality/valueThese outcomes augment understanding of practises in which transformational leaders endorse innovation, and emphasise the values added through endorsing more TL behaviours to yield more innovative outputs by employees.
Understanding the link between socially responsible human resource management and competitive performance in SMEs
Authors: Lechuga Sancho María Paula , Martínez-Martínez Domingo , Larran Jorge Manuel , Herrera Madueño Jesús 
Published: June 2018

PurposeRegardless of the noteworthy growth in research and practice associating corporate social responsibility (CSR) with human resource management, little has been written in regard to one major dimension of CSR in small- and medium-sized enterprises (SMEs), as CSR policies and practices are directed toward employees. The purpose of this paper is to develop and test a conceptual framework connecting socially responsible human resource management (SRHRM) to competitive performance that fits small business.Design/methodology/approachIn order to get empirical evidence, structural equation modeling technique was applied on the data from 481 Spanish SMEs.FindingsResults confirm both the direct contribution of SRHRM to business competitiveness and the multiple effects resulting from including two variables of additional interest for the relationship under study: employee’s commitment and relational marketing.Practical implicationsOne of the main research limitations is that the paper only reflects the perceptions of owners/managers of SMEs. Although it was believed that the respondents give reliable and accurate information about the way their firms are involved in CSR practices, there is a possibility that they might provide incorrect or incomplete information.Originality/valueThe relationships proposed have never been studied before in context of SMEs. This is a worthwhile endeavor, which makes an empirical contribution.
A mediation model of leaders’ favoritism
Authors: Chang Man-Ling , Cheng Cheng-Feng 
Published: June 2018

PurposeThe purpose of this paper is to develop a mediation model for understanding how favoritism, in the context of the leader–member exchange (LMX) theory, influences subordinate-rated LMX via the subordinates’ perception of organizational justice.Design/methodology/approachThe sample comprised 39 managers and 159 employees working in local branches of banks in Taiwan. While the managers were asked to rate their LMX scores with all employees, three to five employees were randomly selected to participate in a survey which included two phases with a time lag of three months. Given the nested structure of the data, hierarchical linear modeling was used to examine the mediation model.FindingsThe findings support the mediation model, indicating that LMX favoritism can significantly influence subordinate-rated LMX by enhancing subordinates’ justice perception.Originality/valueThe study contributes to the existing LMX research by showing that a superior’s LMX favoritism may change subordinate-rated LMX over time.
Maintenance of soil ecotypes ofSolidago virgaureain close parapatry via divergent flowering time and selection against immigrants
Authors: Sakaguchi Shota , Horie Kenji , Ishikawa Naoko , Nishio Sae , Worth James R. P. , Fukushima Keitaro , Yamasaki Michimasa , Ito Motomi 
Published: June 2018

AbstractThe often patchy distribution of serpentine geology can lead to abrupt changes in soil and microclimates. Thus, serpentine areas provide an ideal natural setting to understand how divergent selection drives the process of local adaptation in edaphically specialized plants. When the serpentine ecotype is surrounded by a related nonserpentine ecotype, a balance of natural selection and potential gene flow should maintain the different ecotypes over very short distances. We aimed to reveal the mechanisms allowing soil ecotypes of a goldenrod species to co‐occur sympatrically in Japan.We performed field surveys to characterize microenvironments and flowering phenology of each ecotype, common garden and reciprocal transplant experiments and artificial crossing, and population genetic analysis to investigate the levels of genetic differentiation between ecotypes.Growth chamber experiments show that serpentine plants showed lower specific leaf area (SLA) and greater resource allocation to their root systems than did their nonserpentine counterparts, a potential adaptation to drier and less fertile soil condition in serpentine habitats. Reciprocal transplant studies demonstrated a clear pattern of local adaptation in the plant growth rate. Importantly, serpentine populations completed flowering by midsummer versus late summer in nonserpentine plants. This pattern is consistent with the hypothesis that early flowering ensures reproductive success, before the microclimatic conditions becomes severe in open habitats. Although prezygotic isolation was a strong barrier to gene flow, genetic differentiation was very low, indicating a recent origin for the serpentine ecotypes and/or gene flow at low frequencies.Synthesis. The findings indicate that the early flowering times of serpentine ecotypes, which would have been selected for by microclimates in serpentine areas, can play roles in local adaptation, but also population isolation via a by‐product of diverged reproductive timings. This study contributes to general understanding of the initial stages of plant ecological speciation under potential gene flow in very small geographic scales.
Qualitative insights into the experience of pain in older Australian women with arthritis
Authors: de Luca Katie , Parkinson Lynne , Hunter Sharyn , Byles Julie Ellen 
Published: June 2018

ObjectiveTo explore qualitative insights into the pain experience of older women with quantitatively derived pain profiles.MethodsThe sequential mixed methods design involved applying quantitative pain profiles, derived from an earlier latent class analysis, to qualitative comments by a sample of older Australian women with arthritis. Data from a substudy of the Australian Longitudinal Study on Women's Health, mid‐aged cohort, born 1946–1951, were used. Inductive content analysis was conducted to explore qualitative insights into the experience of pain.ResultsThe average age of women was 64.6 years (±1.4). Within each derived pain profile, themes generated from the qualitative comments of women were concordant with the profile descriptors: ‘I manage my pain’ for the uni‐dimensional, mild pain profile (comments from 56 women); ‘I live with pain every day’ and ‘I rely on medication regularly’ for the moderate multidimensional pain profile (comments from 39 women); and ‘multiple pains’, ‘I suffer with pain’ and ‘I am unable and adjust’ for the severe multidimensional pain profile (comments from 31 women).ConclusionWomen with different pain profiles used different language and strategies in managing their pain experience, information which can guide clinicians to provide more tailored support for self‐management and care of arthritis pain.
Immersion in Indigenous Agriculture and Transformational Learning
Authors: Mandala Lukoff Maya 
Published: June 2018

SUMMARYThis article is an autoethnography of the author's four‐year transformational educational journey ​studying, working, and conducting research on indigenous agriculture while living and participating in indigenous communities in Latin America. Autoethnographic methods are used here to explore personal identity and a sense of what constitutes “home.” As my learning journey unfolded, I was at the intersection of two worldviews—indigenous and my upbringing in the United States—while exploring modern “certainties” regarding development work in education, universal rights, and agricultural advancement. In this process, my relationship to nature and my own native soil emerged as a new perspective. Reflections, anecdotes, and art are incorporated to personalize the telling of the story. The unique value of travel for transformational learning is highlighted.
Kukama Runa: Polyphonic Aesthetics in Cine Comunitario Among the Napo Runa of Amazonian Ecuador
Authors: Bermúdez A. Patricia , Uzendoski Michael A. 
Published: June 2018

SUMMARYThis essay describes a collective experience of cine comunitario (community cinema) as a humanistic method for (re)telling narratives, for working in a polyphonic audiovisual mode, and for transmitting ontological perspectives of life, poetics, and communitas to diverse audiences. Specifically, we share our story of a collective journey, that of making the Kichwa film Kukama Runa, a 36‐minute fictional work based on a Napo Runa myth.