bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linseed and Complex Rosin Ester Oils Additivated with MWCNTs and Nanopearls for Gears/Wheel‐Rail Systems
Authors: Pérez‐de Brito Andrey Fabio , Ponce Suhey , Pérez‐Robles Juan Francisco , Higuera‐Ciapara Inocencio , Toro Alejandro , Esparza Rodrigo , Medina Dora Iliana , Villaseñor‐Ortega Francisco , Luna‐Barcenas Gabriel 
Published: October 2019

AbstractAn innovative biolubricant for gears/wheel‐rail systems is formulated; it is produced inexpensively using high‐viscosity vegetable oils modified with additives of unpurified carbon nanopearls (CNPs) and MWCNTs produced via carbon‐vapor deposition. Traditional lubricants made from non‐renewable sources can be replaced with such additive‐based oils. The addition of both unpurified carbon nanopearls and nanotubes containing nanoparticles of Fe, Ni, Co, or SiO2 is a simple way to improve the tribological properties of biolubricants. Therefore, carbon nanostructures used as additives are not required to be purified or functionalized, thus reducing production costs. Tribological testing is performed with ball‐on‐disc, four‐ball, and twin‐disc machines for two high‐viscosity biolubricants. A complex rosin ester and linseed oil additivated with commercial and raw CNPs/MWCNTs are tested. Scanning electron microscope characterization is used to assess the morphology and structure of both the carbon nanopearls and the multiwalled carbon nanotube particles in addition to the worn metal surfaces. Additionally, X‐ray diffraction, FTIR spectroscopy, and inductively coupled plasma atomic emission spectroscopy are used to characterize the MWCNTs additives.Practical Applications: Biolubricant additivation with raw unpurified MWCNTs and CNPs for enhanced tribological performance. Presence of Fe, Ni, Co, and Si nanoparticles helps fine‐tune the friction coefficient and anti‐wear rates. The proposed method may prove useful in biolubricant formulation for applications in gears/wheel‐rail and metal machining systems.
Study on the disaster reduction mechanism of presplitting blasting and reasonable blasting parameters for shallowly buried remnant pillars
Authors: Yuan Yong , Yuan Chao‐feng , Zhu Cheng , Liu Han‐xiang , Wang Sheng‐zhi 
Published: October 2019

AbstractDisasters such as support crushing easily occur at the mining face under a shallowly buried remnant pillar; therefore, a method for presplitting blasting remnant pillars to relieve stress concentrations and reduce disaster occurrence is proposed. Based on the geological conditions of Nanliang Mine, combining theoretical analysis and numerical simulation to study the bearing characteristics and stress distribution characteristics of remnant pillars, the influence mechanism of presplitting blasting on remnant pillars in terms of the uncoupling factor, axial charge factor, blast hole arrangement, and detonation method is analyzed, revealing the presplitting blasting and disaster reduction mechanism of shallowly buried remnant pillars; furthermore, reasonable blasting parameters are determined. The results show that the rock is affected by the concentrated load within 40 m below the coal pillar; the reasonable blasting parameters are the uncoupled charge coefficient of 1.5, the axial charge factor of 1.0, and the simultaneous detonation of staggered holes. Blasting coal pillars can reduce the transmission effect of the overlying load and ensure the safe use of low‐resistance hydraulic support.
The efficiency and market‐power interpretations of the multinational enterprise: Two out of three ain't bad
Authors: Clougherty Joseph A. , Skousen Bradley R. 
Published: October 2019

AbstractResearch SummaryWe contend that contemporary scholarship must embrace the foundational approach in global business and strategy to consider the relevance of both efficiency and market‐power effects in factoring the implications of multinational activity. We empirically test the degree to which efficiency and market‐power effects manifest in a comprehensive sample of 4,370 cross‐border acquisitions materializing between 1986 and 2010. Specifically, we employ three different measurement approaches to distinguish efficiency enhancing from market‐power increasing cross‐border acquisitions. Empirical results indicate that efficiency enhancing transactions manifest in two‐thirds and market‐power increasing transactions manifest in one‐third of our sampled activities. Accordingly, our results affirm the literature's focus on efficiency effects, yet market‐power effects are sufficiently sizable to merit scholarly attention.Managerial SummaryContemporary wisdom generally considers multinational activities to be characterized by efficiency properties. While it is understood that market power may manifest in multinational activity, most observers implicitly assume that anti‐competitive effects are dominated by more‐healthy efficiency effects. Yet, the justification behind the prior that efficiency effects dominate market‐power effects is not evident, as multinational activities conceivably involve substantial market power. Accordingly, we test the received wisdom regarding the dominance of efficiency effects in an extensive sample of cross‐border investments. Our empirical results affirm prevailing assumptions as efficiency enhancing transactions constitute the majority of cross‐border investment activities. However, market‐power increasing transactions manifest as a sizable minority of cross‐border investments; thus, market‐power effects should not be neglected.
Influence of emotional complexity on the neural substrates of affective theory of mind
Authors: Caillaud Marie , Bejanin Alexandre , Laisney Mickael , Gagnepain Pierre , Gaubert Malo , Viard Armelle , Clochon Patrice , de La Sayette Vincent , Allain Philippe , Eustache Francis , Desgranges Béatrice 
Published: October 2019

AbstractAffective theory of mind (ToM) depends on both the decoding of emotional expressions and the reasoning on emotional mental states from social situations. While previous studies characterized the neural substrates underlying these processes, it remains unclear whether the nature of the emotional state inferred from others can influence the brain activation associated with affective ToM. In the present study, we focused on two types of emotions: basic emotions (BEs) (e.g., anger and surprise), which are innate and universal and self‐conscious emotions (e.g., pride and embarrassment), which correspond to a special class of emotions involving the self and including a representation of one's relative reactions to internal and external standards. Specifically, we used an ecological functional MRI paradigm, on 21 healthy young subjects, to compare brain activations during the decoding of and the reasoning on others' self‐conscious, basic and neutral mental states. Our results showed that compared to neutral states, the inference of self‐conscious and basic emotional states from others elicited more activation in several core regions of affective ToM. Direct comparisons between emotional conditions revealed more activation for self‐conscious than BEs in the right temporoparietal junction during the reasoning process and in left middle occipital regions during the decoding process. Further analyses using a localizer task showed that the extrastriate body area was more recruited for decoding others' self‐conscious versus BEs, which emphasize the importance of body clues to properly infer these emotions. Using an original task allowing for an ecological assessment of the affective ToM, these results demonstrate that the complexity of the emotion inferred to others can influence the recruitment of ToM network. This study also validates the use of our task as an ecological tool to assess the affective ToM, constituting an avenue for the characterization of ToM impairments in neurological conditions.
Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy
Authors: Hsieh Jason Chia‐Hsun , Wang Hung‐Ming , Wu Min‐Hsien , Chang Kai‐Ping , Chang Pei‐Hung , Liao Chun‐Ta , Liau Chi‐Ting 
Published: October 2019

AbstractBackgroundBiomarkers in head and neck squamous cell carcinoma (HNSCC) emerge rapidly in recent years, especially for new targeted therapies and immunotherapies.MethodsRecent, relevant peer‐reviewed evidence were critically reviewed and summarized.ResultsThis review article briefly introduces essential biomarker concepts, including purposes and classifications (predictive, prognostic, and diagnostic markers), and the phases of biomarker development. We summarize current biomarkers in order of clinical utility; p16 and human papillomavirus status remain the most important and validated biomarkers in HNSCC. The rationale for biomarker study design continues to evolve with technological advances, especially whole‐exome or whole‐genomic sequencing. Noninvasive body fluid and liquid biopsy biomarkers appear to hold strong potential for development as tools for early cancer detection, cancer diagnosis, monitoring of disease recurrence, and outcome prediction. In light of discrepancies among different technologies, standardized approaches are needed.ConclusionBiomarkers from cancer tissue or blood in HNSCC could direct new anticancer therapies.
Effects of oral and oropharyngeal cancer on speech intelligibility using acoustic analysis: Systematic review
Authors: Balaguer Mathieu , Pommée Timothy , Farinas Jérôme , Pinquier Julien , Woisard Virginie , Speyer Renée 
Published: October 2019

AbstractBackgroundThe development of automatic tools based on acoustic analysis allows to overcome the limitations of perceptual assessment for patients with head and neck cancer. The aim of this study is to provide a systematic review of literature describing the effects of oral and oropharyngeal cancer on speech intelligibility using acoustic analysis.MethodsTwo databases (PubMed and Embase) were surveyed. The selection process, according to the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) statement, led to a final set of 22 articles.ResultsNasalance is studied mainly in oropharyngeal patients. The vowels are mostly studied using formant analysis and vowel space area, the consonants by means of spectral moments with specific parameters according to their phonetic characteristic. Machine learning methods allow classifying “intelligible” or “unintelligible” speech for T3 or T4 tumors.ConclusionsThe development of comprehensive models combining different acoustic measures would allow a better consideration of the functional impact of the speech disorder.
Prognostic implications of human papillomavirus status and p16 expression in laryngeal squamous cell carcinoma
Authors: Zhu Yingying , Xia Xin , Gross Neil , Dahlstrom Kristina R. , Gao Liming , Liang Zhiyong , Gao Zhiqiang , Wei Peng , Liu Chuan , Li Guojun , Li Yuncheng , Chen Xingming 
Published: October 2019

AbstractBackgroundThe purpose of this study was to investigate significance of HPV16 DNA/p16 for survival of patients with laryngeal squamous cell carcinoma (LSCC).MethodsHPV16 DNA and p16 status in 812 LSCC patients were determined. The survival was performed using Kaplan‐Meier estimates and Cox model.ResultsCompared with HPV negativity, adjusted HRs for HPV16 positivity were 0.57, 95% CI, 0.38 to 0.87; 0.60, 0.40 to 0.88; and 0.65, 0.46 to 0.94 for disease‐specific survival (DSS), recurrence‐free survival (RFS), and overall survival (OS), respectively. Additionally, for p16 expression, aHRs were 0.68, 95% CI, 0.48 to 0.96; 0.72, 0.52 to 0.98; and 0.73, 0.54 to 0.99 for DSS, RFS, and OS, respectively. Finally, for combined analysis, patients with both HPV16‐positivity/p16‐positivity had much better prognosis than those with either negativity. Such above survivals are more significantly better in never smokers.ConclusionOur findings suggest that HPV16/p16 may affect survival outcomes of LSCC patients, particularly in never smokers.
Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats
Authors: Yamada Eloá F. , Bobinski Franciane , Martins Daniel F. , Palandi Juliete , Folmer Vanderlei , da Silva Morgana D. 
Published: October 2019

AbstractKnee osteoarthritis (OA) is a chronic disease that causes pain and gradual degeneration of the articular cartilage. In this study, MIA‐induced OA knee model was used in rats to test the effects of the photobiomodulation therapy (PBM). We analyzed the inflammatory process (pain and cytokine levels), and its influence on the oxidative stress and antioxidant capacity. Knee OA was induced by monosodium iodoacetate (MIA) intra‐articular injection (1.5 mg/50 μL) and the rats were treated with eight sessions of PBM 3 days/week (904 nm, 6 or 18 J/cm2). For each animal, mechanical and cold hyperalgesia and spontaneous pain were evaluated; biological analyses were performed in blood serum, intra‐articular lavage, knee structures, spinal cord and brainstem. Cytokine assays were performed in knee, spinal cord and brainstem samples. The effects of the 18 J/cm2 dose of PBM were promising in reducing pain and neutrophil activity in knee samples, together with reducing oxidative stress damage in blood serum and spinal cord samples. PBM improved the antioxidant capacity in blood serum and brainstem, and decreased the knee pro‐inflammatory cytokine levels. Our study demonstrated that PBM decreased oxidative damage, inflammation and pain. Therefore, this therapy could be an important tool in the treatment of knee OA.
MicroRNA‐9 overexpression suppresses vulnerable atherosclerotic plaque and enhances vascular remodeling through negative regulation of the p38MAPK pathway via OLR1 in acute coronary syndrome
Authors: Yu Dao‐Rui , Wang Tao , Huang Jing , Fang Xing‐Yue , Fan Hao‐Fei , Yi Guo‐Hui , Liu Qiang , Zhang Yu , Zeng Xiang‐Zhou , Liu Qi‐Bing 
Published: October 2019

AbstractAcute coronary syndrome (ACS) is characterized by atherosclerotic plaque rupture with a high incidence of recurrent ischemic events. Several microRNAs are found to be aberrantly expressed in atherosclerotic plaques. This study aims to investigate the effects of microRNA‐9 (miR‐9) on vulnerable atherosclerotic plaque and vascular remodeling in ACS and underlying mechanisms. Microarray‐based gene expression profiling was used to identify differentially expressed genes related to ACS and regulatory miRNAs. Oxidized low‐density lipoprotein (lectin‐like) receptor 1 (OLR1) was identified to be aberrantly activated in ACS and regulated by miR‐9. OLR1 was verified as a target gene of miR‐9 by bioinformatics prediction and dual luciferase reporter gene assay. The atherosclerotic models were induced in ApoE−/− mice, in which the agomir or antagomir of miR‐9, or small interfering RNA (siRNA) against OLR1 were separately introduced. Serum lipid levels and expression of vascular remodeling and inflammatory response‐related factors were determined, respectively. On the basis of the obtained results, in the atherosclerosis mice treated with the agomir of miR‐9 and siRNA against OLR1, the p38‐mitogen‐activated protein kinase (p38MAPK) pathway was inhibited; levels of triglyceride, total cholesterol, low‐density lipoprotein cholesterol, tumor necrosis factor‐α, interleukin‐6, and vascular endothelial growth factor were reduced, but the high‐density lipoprotein cholesterol level was increased, along with decreased vulnerable atherosclerotic plaque area and enhanced vascular remodeling. Taken together, these findings suggested an inhibitory role miR‐9 acts in the formation of vulnerable atherosclerotic plaques in ACS mice, along with a promoted vascular remodeling, via a negative feedback regulation of OLR1‐mediated p38MAPK pathway.
Intramolecular cross‐dehydrogenative coupling of benzaldehyde derivatives: A novel and efficient route to benzocyclic ketones
Authors: Chen Jun , Sheykhahmad Fatima Rashid 
Published: October 2019

AbstractBenzocyclic ketones are not only found throughout many natural products and synthetic pharmaceutically active compounds but also used as versatile building blocks in organic synthesis. In view of their importance, many researchers have been working to explore novel and efficient synthetic routes for this class of carbonyl compounds. Recently, cross‐dehydrogenative coupling reactions have emerged as one of the most versatile and powerful synthetic strategies to construct various carbon‐carbon and carbon‐heteroatom bonds. In this regard, direct acylation of (hetero)arenes with aldehydes through C(sp2)‐H activation opened up a new page on the synthesis of the titled compounds. In this focus‐review, we discuss the most representative and important reports on the synthesis of cyclic diaryl ketones through intramolecular cross‐dehydrogenative coupling reactions of corresponding benzaldehydes with emphasis on the mechanistic aspects of the reactions.
Association between nucleotide excision repair gene polymorphism and colorectal cancer risk
Authors: Zhang Yujie , Wu Shenshen , Zhou Xiumei , Huang Fang , Chen Rui , Wang Yigang , Wu Jiong 
Published: October 2019

AbstractBackgroundThe nucleotide excision repair system removes a wide variety of DNA lesions from the human genome, and plays an important role in maintaining genomic stability. Single nucleotide polymorphisms (SNPs) in nucleotide excision repair are associated with the various forms of tumor susceptibility. However, the relationship between NER polymorphism and colorectal cancer is not clear.MethodsIn this study, three candidate SNPs including ERCC4 (rs6498486), ERCC1 (rs3212986), and ERCC5 (rs17655) were analyzed in 1101colorectal cancer patients and 1175 healthy control patients from Jiangsu province (China). Then, we performed Immunohistochemistry, qPCR, and luciferase assay to determine the potential mechanisms.ResultsThe ERCC4 rs6498486 AC/CC genotypes show lower susceptibility to CRC than those carrying rs6498486 AA (Adjusted OR = 0.82, 95% CI = 0.69‐0.97). However, we did not observe any association between the colorectal cancer risk and the rs3212986(ERCC1) and rs17655(ERCC5) polymorphisms. Immunohistochemistry, qPCR, and luciferase assay revealed that rs6498486 A > C polymorphism in the ERCC4 promoter region could lessen the expression level of ERCC4 by impacting the binding ability of the transcription factor NF‐kB, thereby affecting the transcription activity of the ERCC4 gene and decreased ERCC4 gene expression.ConclusionIn brief, our finding demonstrated that ERCC4 rs6498486 serves as a potential biomarker of CRC susceptibility for the development of colorectal cancer.
Overcoming trastuzumab resistance in HER2‐positive breast cancer using combination therapy
Authors: Derakhshani Afshin , Rezaei Zohreh , Safarpour Hossein , Sabri Morteza , Mir Atefeh , Sanati Mohammad Amin , Vahidian Fatemeh , Gholamiyan Moghadam Ali , Aghadoukht Ali , Hajiasgharzadeh Khalil , Baradaran Behzad 
Published: October 2019

AbstractHuman epidermal growth factor receptor 2 (HER2)‐positive breast cancer (BC) comprises around 20–30% of all BC subtypes and is correlated with poor prognosis. For many years, trastuzumab, a monoclonal antibody, has been used to inhibit the HER2 activity. Though, the main resistance to trastuzumab has challenged the use of this drug in the management of HER2‐positive BC. Therefore, the determination of resistance mechanisms and the incorporation of new agents may lead to the development of a better blockade of the HER family receptor signaling. During the last few years, some therapeutic drugs have been developed for treating patients with trastuzumab‐resistant HER2‐positive BC that have more effective influences in the management of this condition. In this regard, the present study aimed at reviewing the mechanisms of trastuzumab resistance and the innovative therapies that have been investigated in trastuzumab‐resistant HER2‐positive BC subjects.
Long noncoding RNA LINC00657 induced by SP1 contributes to the non‐small cell lung cancer progression through targeting miR‐26b‐5p/COMMD8 axis
Authors: Zhang Rui , Niu Zequn , Pei Honghong , Peng Zhuo 
Published: October 2019

AbstractNon‐small‐cell lung cancer (NSCLC) is a kind of lung cancer with high incidence and poor outcomes all over the world. Studies have validated that the upregulation of long noncoding RNA LINC00657 is related to several cancers. Nevertheless, the underlying regulatory mechanism of LINC00657 in NSCLC has not been well elucidated. In the present study, quantitative reverse‐transcription polymerase chain reaction (RT‐qPCR) revealed that LINC00657 level was apparently elevated in NSCLC cells. Loss‐of function assays demonstrated that LINC00657 silence retarded cell proliferation and migration in NSCLC cells. Moreover, the chromatin immunoprecipitation result identified the transcription factor SP1 could bind with LINC00657 promoter, and RT‐qPCR proved SP1 positively regulated LINC00657 expression in NSCLC cells. In addition, the mechanistic investigations unveiled that LINC00657 was an endogenous sponge of miR‐26b‐5p and therefore boosted the expression of copper metabolism MURR1 domain‐containing 8 (COMMD8), one of the targets of miR‐26b‐5p. Besides, miR‐26b‐5p could negatively regulate LINC00657 or COMMD8 in NSCLC cells. With the application of rescue assays, we uncovered that overexpression of COMMD8 partly mitigated the impairment of LINC00657 repression on NSCLC cell proliferation and migration. Together, our study illustrated that SP1‐stimulated LINC00657 promoted NSCLC progression through targeting miR‐26b‐5p/COMMD8 axis, offering a novel potential therapeutic target for NSCLC.
The potential role of stromal cell‐derived factor‐1α/CXCR4/CXCR7 axis in adipose‐derived mesenchymal stem cells
Authors: Ji Fukang , Wang Yicheng , Yuan Jinxue , Wu Qiong , Wang Jinhuang , Liu Dalie 
Published: October 2019

AbstractTo investigate the potential role of stromal cell‐derived factor‐1α (SDF‐1α)/CXCR4/CXCR7 axis in adipose‐derived mesenchymal stem cells (ADSCs), quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) was employed to screen the effective small interfering RNA against CXCR4 and CXCR7 in ADSCs. The messenger RNA (mRNA) and proteins abundances of AKT (p‐AKT), ERK (p‐ERK), JNK (p‐JNK), and p38 (p‐p38) in different groups were identified by qRT‐PCR, western blot, and immunofluorescence staining method. Meanwhile, cell migration and cell proliferation with SDF‐1 treated were examined by a 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay and transwell permeable assay, respectively. Moreover, the interaction between CXCR4 and CXCR7 was examined by a GST pull‐down assay. CXCR4 small interfering RNA3 (siRNA3) and CXCR7 siRNA3 have been proved to the most effective tools for knockdown CXCR4 and CXCR7 expressions. mRNA abundance of JNK and p38 could be affected by SDF‐1α/CXCR4/CXCR7 axis. However, western blot analysis of p‐AKT, p‐ERK, p‐JNK, and p‐p38 in CXCR43‐treated ADSCs was significantly higher than that in the control group. Moreover, the immunofluorescence staining analysis revealed that the expressions of p‐ATK and p‐JNK proteins were significantly higher in NC‐ and SDF‐1‐treated subgroups than that in the CXCR4 and CXCR7 groups. p‐ATK and p‐JNK proteins in CXCR4 group were similar to that in CXCR7 group. Cell migration analysis of CXCR4‐treated ADSCs suggested that knockdown CXCR4 could effectively promote cell migration (p < .05). Moreover, CXCR4 could interact with CXCR7. The results in this study could provide a better understanding of SDF‐1α/CXCR4/CXCR7 axis during ADSCs development.