bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chitosan porous 3D scaffolds embedded with resolvin D1 to improve in vivo bone healing
Authors: Vasconcelos Daniela P. , Costa Madalena , Neves Nuno , Teixeira José H. , Vasconcelos Daniel M. , Santos Susana G. , Águas Artur P. , Barbosa Mário A. , Barbosa Judite N. 
Published: February 2018

AbstractThe aim of this study was to investigate the effect chitosan (Ch) porous 3D scaffolds embedded with resolvin D1 (RvD1), an endogenous pro‐resolving lipid mediator, on bone tissue healing. These scaffolds previous developed by us have demonstrated to have immunomodulatory properties namely in the modulation of the macrophage inflammatory phenotypic profile in an in vivo model of inflammation. Herein, results obtained in an in vivo rat femoral defect model demonstrated that two months after Ch + RvD1 scaffolds implantation, an increase in new bone formation, in bone trabecular thickness, and in collagen type I and Coll I/Coll III ratio were observed. These results suggest that Ch scaffolds embedded with RvD1 were able to lead to the formation of new bone with improvement of trabecular thickness. This study shows that the presence of RvD1 in the acute phase of the inflammatory response to the implanted biomaterial had a positive role in the subsequent bone tissue repair, thus demonstrating the importance of innovative approaches for the control of immune responses to biomedical implants in the design of advanced strategies for regenerative medicine. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1626–1633, 2018.
A case‐control study and meta‐analysis reveal the association between COX‐2 G‐765C polymorphism and primary end‐stage hip and knee osteoarthritis
Authors: Huang Wei , Deng Chen , Tian Feng , Gao Weilu , Ding Zhenfei , Rao Xianliang , Yin Zongsheng 
Published: February 2018

BackgroundOsteoarthritis (OA) is a popular arthrosis featured as pain, limited joint activity, and deformity. Cyclooxygenase‐2 (COX‐2) has been reported to be up‐regulated in arthritic tissues and is integral to the progression of osteoarthritis (OA). Previous studies showed the COX‐2 promoter G‐765C polymorphism could influence COX‐2 expression. However, the relationship between the variant and OA risk is contrasting.MethodsWe conducted a case‐control study with 196 primary end‐stage hip and knee OA cases and 196 controls in a Chinese Han population. Subsequently, we integrated this case‐control study in a meta‐analysis to acquire greater statistical power. The results from our case‐control study using MassARRAY genotyping technology and binary logistic regression statistical methods.ResultsThe variant carriers in the Chinese Han population had a lower primary end‐stage hip and knee OA susceptibility (C vs G: OR = 0.350, 95%CI: 0.154‐0.797, P = .012; GC vs GG: adjusted OR = 0.282, 95%CI: 0.118‐0.676, P = .005). Stratification studies indicated that a higher GC frequency in women decreased not only knee OA susceptibility but also unilateral knee OA risk. The meta‐analysis showed that the variant exhibited a significantly decreased OA risk through comparisons involving allelic, homozygous, heterozygous, and dominant models.ConclusionOur findings suggest that the COX‐2 G‐765C polymorphism exerts a protective effect against primary end‐stage knee osteoarthritis in a female Chinese Han population.
Proposal for new selection criteria considering pre‐transplant muscularity and visceral adiposity in living donor liver transplantation
Authors: Hamaguchi Yuhei , Kaido Toshimi , Okumura Shinya , Kobayashi Atsushi , Shirai Hisaya , Yao Siyuan , Yagi Shintaro , Kamo Naoko , Okajima Hideaki , Uemoto Shinji 
Published: February 2018

AbstractBackgroundThe significance of pre‐operative body composition has recently attracted much attention in various diseases. However, cut‐off values for these parameters remain undetermined, and these factors are not currently included in selection criteria for recipients of living donor liver transplantation (LDLT).MethodsUsing computed tomography of 657 donors for LDLT, skeletal muscle mass, muscle quality, and visceral adiposity were evaluated by using skeletal muscle mass index (SMI), intramuscular adipose tissue content (IMAC), and visceral‐to‐subcutaneous adipose tissue area ratio (VSR). Sex‐specific cut‐offs for SMI, IMAC, and VSR were determined, and correlations with outcomes after LDLT in 277 recipients were examined with the aim of establishing new selection criteria for LDLT.ResultsOn the basis of younger donor data, we determined sex‐specific cut‐off values for low SMI, high IMAC, and high VSR (mean ± 2 standard deviations). Patients with all three factors showed the lowest survival rate after LDLT (1 year survival rate, 41.2%; P < 0.001). On multivariate analysis, low SMI (P = 0.002), high IMAC (P = 0.002), and high VSR (P = 0.001) were identified as independent risk factors for mortality after LDLT. Based on these findings, we have excluded patients showing all three factors (low SMI, high IMAC, and high VSR) as candidates for LDLT since October 2016.ConclusionsUsing cut‐off values determined from healthy donors, we have established new selection criteria for LDLT including body composition, which should improve post‐transplant outcomes.
Metals in aqueous solutions and real effluents: biosorption behavior of a hemp‐based felt
Authors: Loiacono Sonia , Crini Grégorio , Chanet Gilles , Raschetti Marina , Placet Vincent , Morin‐Crini Nadia 
Published: February 2018

AbstractBACKGROUNDIn this study, a hemp‐based material in the form of a felt was used to adsorb metals in individual aqueous solutions and in polycontaminated effluents using the batch method. The factors affecting the biosorption process were initial metal concentration, biosorbent dosage, contact time and pH.RESULTSIn controlled conditions, results showed that: (i) the felt exhibited high adsorption capacities towards metals in the following order: Pb > Cd > Cu > Zn > Co ∼ Fe ∼ Ni ∼ Cr ∼ Al ∼ Mn; (ii) no significant differences were observed for the three salts used (sulfate, chloride and nitrate); (iii) the process was rapid: 10 min were sufficient to attain equilibrium; (iv) the biosorption efficiency increased considerably with the increase of the biosorbent dosage; and (v) the adsorption capacities were independent of pH between 4 and 6. The maximum adsorption capacities for Cd, Cu, Zn, Co, Fe, Ni, Cr, Al and Mn were 27.47, 14.64, 10.59, 7.99, 7.85, 7.87, 6.53, 6.38 and 4.55 mg g–1, respectively. Interesting results also were obtained for real polymetallic effluents. Ecotoxicological tests also confirmed the efficiency of the biosorption to radically decrease the effluent toxicity.CONCLUSIONSBased on these results, hemp‐based felt could serve as a novel and efficient biosorbent material for pollutant removal from industrial effluents. © 2018 Society of Chemical Industry
An Efficient One‐Pot Synthesis of Highly Substituted Pyridone Derivatives and Their Antimicrobial and Antifungal Activity
Authors: Pandit Archana B. , Savant Mahesh M. , Ladva Kartik D. 
Published: February 2018

A series of carboxamide and cyano functionalized pyridone derivatives 4a–q have been synthesized via one‐pot synthesis of various aldehydes 1a–q, acetoacetanilide 2, and cyanoacetamide 3. The reaction was simple and afforded pyridone derivatives in good yield, 89 to 93%. The novel pyridone derivatives were achieved by Hantzch one‐pot synthesis. Moreover, the synthesized compounds were screened against Gram‐positive and Gram‐negative bacteria and fungi for their activity. Among them, compound 4c shows highest inhibition at 4.25 mm against Staphylococcus aureus and 3.75 mm against Escherichia coli Gram‐positive and Gram‐negative bacteria, respectively.
Electrospray mass spectrometry and molecular modeling study of formation and stability of silver complexes with diazaperylene and bisisoquinoline
Authors: Starke Ines , Koch Andreas , Kammer Stefan , Holdt Hans‐Jürgen , Möller Heiko Michael 
Published: February 2018

AbstractThe complex formation of the following diazaperylene ligands (L) 1,12‐diazaperylene 1, 1,1′‐bisisoquinoline 2, 2,11‐disubstituted 1,12‐diazaperylenes (alkyl = methyl, ethyl, isopropyl, 3, 5, 7), 3,3′‐disubstituted 1,1′‐bisisoquinoline (alkyl = methyl, ethyl, isopropyl, 4, 6, 8 and with R = phenyl, 11 and with pyridine 12), and the 5,8‐dimethoxy‐substituted diazaperylene 9, 6,6′‐dimethoxy‐substituted bisisoquinoline 10 with AgBF4 was investigated. Collision‐induced dissociation measurements were used to evaluate the relative stabilities of the ligands themselves and for the [1:1]+ complexes as well as for the homoleptic and heteroleptic silver [1:2]+ complexes in the gas phase. This method is very useful in rapid screening of the stabilities of new complexes in the gas phase. The influence of the spatial arrangement of the ligands and the type of substituents employed for the complexation were examined. The effect of the preorganization of the diazaperylene on the threshold activation voltages and thus of the relative binding energies of the different complexes are discussed. Density functional theory calculations were used to calculate the optimized structures of the silver complexes and compared with the stabilities of the complexes in the gas phase for the first time.
Electrospray ionization source with a rear extractor
Authors: Chen Lee Chuin , Tsutsui Satoru , Naito Tsubasa , Ninomiya Satoshi , Hiraoka Kenzo 
Published: February 2018

AbstractA new electrospray source design is introduced by having an extractor electrode placed at 1 to 2 mm behind the emitter tip. The extractor was integrated into the sprayer body as a single device. An insulating tube was used to isolate the emitter from the extractor and to deliver the sheath gas for the electrospray. The electric field strength at the emitter was primarily determined by the relative position and the potential between the needle and the extractor; therefore, the spraying condition was insusceptible to the change of sprayer position or orientation with respect to the ion sampling inlet. Such design allowed the use of much lower operating voltage and facilitated the optimization of sprayer position by keeping the electric field parameter constant. Using an emitter capillary of 150 and 310 μm in inner and outer diameters, strong ion signal could still be acquired with 2‐kV emitter potential even if the distance between the emitter and ion inlet was extended to >70 mm. Charge reduction of protein ions using 2 extractor‐based electrosprays of opposite emitter polarities was also demonstrated.
In search of appropriate measures of periodontal status: The Periodontal Profile Phenotype (P3) system
Authors: Beck James D. , Moss Kevin L. , Morelli Thiago , Offenbacher Steven 
Published: February 2018

AbstractBackgroundThis paper focuses on Periodontal Profile Class (PPC), a component of the Periodontal Profile Phenotype (P3) System that may be more representative of the periodontitis phenotype than current case definitions of periodontitis. Data illustrate the unique aspects of the PPC compared with other commonly used periodontal classification indices.MethodsLatent Class Analysis (LCA) identified discrete classes of individuals grouped by tooth‐level clinical parameters. The analysis defined seven distinct periodontal profile classes (PPC A through G) and seven distinct tooth profile classes (TPC A through G). This LCA classification was an entirely data‐derived agnostic process without any preconceived presumptions of what constituted disease.ResultsComparing the PPC with the Centers for Disease Control/American Academy of Periodontology (CDC/AAP) and European indices, the PPC is unique in that it contains four disease classes not traditionally used. Less than half of individuals classified as Healthy by both the CDC/AAP and European indices were Healthy using the PPC. About 25% of those classified as Severe by CDC/AAP and European indices were PPC‐Severe. The remainder spread out over the High Gingival Index, Posterior Disease, Tooth Loss, and Severe Tooth Loss phenotypes.ConclusionsThe PPC classification provides a significant departure from the traditional clinical case status indices that have been used, but has resulted in clinical phenotypes that are quite familiar to most clinicians who take notice of the distribution of missing teeth, areas of recession, diminished periodontal support, and other aspects of the dentition while conducting a periodontal examination. The mutually exclusive categories provided by the PPC system provide periodontal clinical summaries that can be an important component of precision dentistry.
Simulation of the upper airways in patients with obstructive sleep apnea and nasal obstruction: A novel finite element method
Authors: Henrik Strand Moxness Mads , Wülker Franziska , Helge Skallerud Bjørn , Nordgård Ståle 
Published: February 2018

ObjectiveTo evaluate the biomechanical properties of the soft palate and velopharynx in patients with obstructive sleep apnea (OSA) and nasal obstruction.Study designProspective experimental study.Materials and methodsTwo finite element (FE) models of the soft palate were created in six patients undergoing nasal surgery, one homogeneous model based on CT images, and one layered model based on soft tissue composition. The influence of anatomy on displacement caused by a gravitational load and closing pressure were evaluated in both models. The strains in the transverse and longitudinal direction were obtained for each patient.ResultsThe individual anatomy influences both its structural stiffness and its gravitational displacement. The soft palate width was the sole anatomical parameter correlated to the critical closing pressure, but the maximal displacement due to gravity may have a relationship to closing pressure of possibly an exponential order. The airway occlusion occurred mainly at the lateral attachments of the soft palate. The total transverse strain showed a strong correlation with maximal closing pressure. There was no relationship between the critical closing pressure and the preoperative AHI levels, or the change in AHI after surgery.ConclusionHyperelastic FE models both in the homogeneous and layered model represent a novel method of evaluating soft tissue biomechanics of the upper airway. The obstruction occurs mainly at the level of the lateral attachments to the pharyngeal wall, and the width of the soft palate is an indicator of the degree of critical closing pressure. A less negative closing pressure corresponds to small total transverse strain. The effect of nasal surgery on OSA is most likely not explained by change in soft palate biomechanics.Level of EvidenceNA.
CBCT‐guided evolutive library for cervical adaptive IMRT
Authors: Rigaud Bastien , Simon Antoine , Gobeli Maxime , Lafond Caroline , Leseur Julie , Barateau Anais , Jaksic Nicolas , Castelli Joël , Williaume Danièle , Haigron Pascal , De Crevoisier Renaud 
Published: February 2018

PurposeIn the context of adaptive radiation therapy (ART) for locally advanced cervical carcinoma (LACC), this study proposed an original cone‐beam computed tomography (CBCT)‐guided “Evolutive library” and evaluated it against four other known radiotherapy (RT) strategies.Material and methodsFor 20 patients who underwent intensity‐modulated radiation therapy (IMRT) for LACC, three planning CTs [with empty (EB), intermediate (IB), and full (FB) bladder volumes], a CT scan at 20 Gy and bi‐weekly CBCTs for 5 weeks were performed. Five RT strategies were simulated for each patient: “Standard RT” was based on one IB planning CT; “internal target volume (ITV)‐based RT” was an ITV built from the three planning CTs; “RT with one mid‐treatment replanning (MidTtReplan)” corresponded to the standard RT with a replanning at 20 Gy; “Pretreatment library ART” using a planning library based on the three planning CTs; and the “Evolutive library ART”, which was the “Pretreatment library ART” strategy enriched by including some CBCT anatomies into the library when the daily clinical target volume (CTV) shape differed from the ones in the library. Two planning target volume (PTV) margins of 7 and 10 mm were evaluated. All the strategies were geometrically compared in terms of the percentage of coverage by the PTV, for the CTV and the organs at risk (OAR) delineated on the CBCT. Inadequate coverage of the CTV and OARs by the PTV was also assessed using deformable image registration. The cumulated dose distributions of each strategy were likewise estimated and compared for one patient.ResultsThe “Evolutive library ART” strategy involved a number of added CBCTs: 0 for 55%; 1 for 30%; 2 for 5%; and 3 for 10% of patients. Compared with the other four, this strategy provided the highest CTV geometric coverage by the PTV, with a mean (min–max) coverage of 98.5% (96.4–100) for 10 mm margins and 96.2% (93.0–99.7) for 7 mm margins (P < 0.05). Moreover, this strategy significantly decreased the geometric coverage of the bowel. CTV undercoverage by PTV occurred in the anterior and superior uterine regions for all strategies. The dosimetric analysis at 7 mm similarly demonstrated that the “Evolutive library ART” increased the V42.75Gy of the CTV by 27%, 20%, 13%, and 28% compared with “Standard RT”, “ITV‐based RT”, “MidTtReplan”, and “Pretreatment library ART”, respectively. The dose to the bowel was also decreased by the “Evolutive library ART” compared with that by the other strategies.ConclusionThe “Evolutive library ART” is a personalized ART strategy that comprises a pretreatment planning library of three CT scans, enriched for half of the patients by one to three per‐treatment CBCTs. This original strategy increased both the CTV coverage and bowel sparing compared with all the other tested strategies and enables us to consider a PTV margin reduction.
Predicted and Observed Responses of a Nonnative Channel Catfish Population Following Managed Removal to Aid the Recovery of Endangered Fishes
Authors: Pennock Casey A. , Durst Scott L. , Duran Bobby R. , Hines Brian A. , Cathcart C. Nathan , Davis Jason E. , Schleicher Benjamin J. , Franssen Nathan R. 
Published: February 2018

Abstract
Human transformation of aquatic systems and the introduction of nonnative species increasingly threaten the persistence of imperiled freshwater fishes. In response, large-scale mechanical removal of nonnative fishes has been implemented throughout parts of the Colorado River basin to aid recovery of endangered fishes, but the effects of these efforts can be difficult to quantify. Fisheries population models for predicting outcomes of harvest regulations have been widely used to prevent overfishing of commercial and game stocks. Here, we used population models to investigate size-specific removal efforts needed to overfish a nonnative population of Channel Catfish Ictalurus punctatus and thereby aid recovery of endangered fishes in the San Juan River, New Mexico and Utah. The minimum size of fish that were efficiently captured with electrofishing gear was 280 mm TL, and annual removal rates increased with fish size, ranging from 0.10 for 200-mm fish to 0.44 for 600-mm fish. Model results suggested that removal rates should be increased from 0.14 to a range of 0.21–0.34 to cause growth overfishing and should be increased to a range of 0.26–0.29 to cause recruitment overfishing at a minimum electrofishing size limit of 280 mm TL. However, model results indicated that overall population abundance and biomass are being substantially reduced compared to an unmanaged population. In concordance, long-term monitoring data from 1991 to 2015 demonstrated a decrease in Channel Catfish TL and mass as well as an increase in catch rate variability since removal efforts intensified in 2006. Overall, current rates of removal will probably not achieve collapse of the nonnative Channel Catfish population in the San Juan River, but the reduction in size structure indicates that the population has responded to these efforts.
Exploring the Psychological Dimensions of Stewardship in Recreational Fisheries
Authors: Landon Adam C. , Kyle Gerard T. , Riper Carena J. , Schuett Michael A. , Park Jihee 
Published: February 2018

Abstract
The sustainability of recreational fisheries is in part dependent on anglers acting as stewards of the resource. However, the psychological attributes that underpin anglers' adoption of voluntarily stewardship behaviors remain largely unknown. In this study, we tested a model of the factors that influence stewardship in the recreational fisheries sector. Specifically, we drew on identity theory to explore the role of one's identification as an angler in shaping moral norms and stewardship behaviors among anglers in Texas. Stewardship behavior was conceptualized along three dimensions related to private-sphere, public-sphere, and social stewardship activities. Data were taken from a statewide, mixed-mode survey of Texas licensed anglers' attitudes, behaviors, and management preferences (n = 948). We hypothesized that one's identity as an angler and moral beliefs about acting as a steward of fisheries resources would predict three dimensions of stewardship behavior. Results indicated that one's identity as an angler is associated with normative beliefs and that these two factors have differential effects on engagement in multiple dimensions of stewardship behaviors.
Influence of Lode angle‐dependent failure criteria on shear localization analysis in sand
Authors: Sisodiya Mitul , Das Arghya 
Published: February 2018

SummaryGeotechnical experiments show that Lode angle‐dependent constitutive formulations are appropriate to describe the failure of geomaterials. In the present study, we have adopted one such class of failure criteria along with a versatile constitutive relationship to theoretically analyze the effects of Lode angle on localized shear deformation or shear band formation in loose sand for both drained and undrained conditions. We determine the variation in the possible stress states for shear localization due to the introduction of Lode angle by considering the localized deformation as a bifurcation problem. Further, similar bifurcation analysis is performed for the stress states along a specific loading path, namely, plane strain compression at the constitutive level. In addition, the plane strain compression tests have been simulated as a boundary value finite element problem to see how Lode angle affects the post‐localization response. Results show that the inclusion of a Lode angle parameter within the failure criterion has considerable effects on the onset, plastic strain, and propagation of shear localization in loose sand specimens. For drained condition, we notice early inception of shear localization and multiple band formation when the Lode angle‐dependent failure criterion is used. Undrained localization characteristics, however, found to be independent of Lode angle consideration.