bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selection of Protein Kinase Inhibitors Based on Tumor Tissue Kinase Activity Profiles in Patients with Refractory Solid Malignancies: An Interventional Molecular Profiling Study
Authors: Labots Mariette , Van der Mijn Johannes C. , Dekker Henk , Ruijter Rita , Pham Thang V. , Van der Vliet Hans J. , Van der Hoeven Jacobus J.M. , Meijer Gerrit A. , Verheul Henk M.W. 
Published: July 2018

Abstract

Lessons Learned
Clinically applicable tools are needed for treatment selection and repurposing of available protein kinase inhibitors (PKIs) in patients with advanced solid tumors refractory to standard treatment. Using a tyrosine kinase peptide substrate microarray, observed inhibitory activity in vitro could not sufficiently predict clinical benefit of treatment with the selected PKI.

Background
This exploratory molecular profiling study determined the feasibility and benefit of the selection of protein kinase inhibitors (PKIs) based on kinase activity profiling in patients with refractory solid malignancies.

Methods
Adult patients with biopsy-accessible refractory solid tumors were eligible. Per patient, the inhibitory potency of sunitinib, dasatinib, erlotinib, sorafenib, everolimus, and lapatinib was determined in tumor lysates from fresh biopsies using a tyrosine kinase peptide substrate microarray. The most active PKI in this in vitro assay was selected for treatment.

Results
Thirteen patients were enrolled in the feasibility part and underwent tumor biopsy. Of 12 patients in whom kinase activity profiling was performed, 11 started treatment with a selected PKI: dasatinib in 8, sunitinib in 2, and erlotinib in 1 patient(s). Eight patients were evaluable for response. One patient had stable disease (SD) &gt;4 months on sunitinib; one patient had SD at 6 weeks but progressive disease (PD) at 12 weeks. The remaining patients had PD after 6 weeks of treatment.

Conclusion
Kinase inhibition profiles of multiple PKIs can be reliably determined using fresh tumor biopsies from patients with refractory solid tumors. However, the current in vitro microarray selection approach insufficiently predicted clinical benefit of PKI treatment in these patients.
Profile of acute upper gastro intestinal bleed: a referral hospital-based study in sub Himalayan region
Authors: C. M. Shyamsundar , Sharma Guru Dutt , Rana Baldev Singh 
Published: July 2018

Background: Acute upper gastrointestinal bleeding (UGIB) is one of the most common medical emergencies and remains a major cause of morbidity and mortality. We are likely to see more of it in coming years with ageing population, patients with liver disease, increasing use of NSAIDs, single or multiple antithrombotic agents and novel anticoagulants, the present study was designed with the aim to assess the clinical profile of UGIB presenting to the Department of Medicine in sub Himalayan region.Methods: Study done over 12 months included all patients presenting with acute hematemesis and/or melena. Detailed history, clinical examination, blood tests and Upper GI Endoscopy was done in all patients.Results: One hundred seventy-five patients were included in the study, 129 (73.7%) were males. The commonest age group was 41-60 years contributing to 44%, male to female ratio 2.8:1. The commonest presentation was melena, patients with hematemesis presented earlier, with mean duration 1.46 days. 42.3% of patients were hemodynamically unstable at admission. The mean hemoglobin (Hb) was 8.224±2.78 g%. The cause of bleed was shared by ulcer, varices, non-ulcer non-variceal approximately 1/3rd each, major cause being ulcer in 39.4%. Varices was common in age 30-40 yrs, ulcer in age 51 to 70 years.Conclusions: UGI bleed was more frequent in males age between 41-60 yrs, peptic ulcer being the leading cause in our study, presence of signs of liver failure were associated with varices.
Hipotiroidismo congénito primario y neurodesarrollo: un enfoque terapéutico integral
Authors: Díaz Pérez Elda Josefina , Sánchez Pérez María del Carmen , Moreno Macías Hortensia , Echeverría Arjonilla Juan Carlos , Rivera González Iván Rolando , Calzada León Raúl , Ruiz-Reyes María de la Luz , Ontiveros Mendoza Esperanza , Altamirano Bustamante Nelly , Mandujano Valdés Mario Antonio 
Published: July 2018

INTRODUCCIÓN: Los pacientes con hipotiroidismo congénito primario tienen menor desarrollo cognitivo y psicomotor comparados con los hermanos sanos o con grupos control (5 a 25 puntos por debajo), por lo que constituyen un desafío para el sector salud. OBJETIVO: Evaluar la función cognitiva de niños con hipotiroidismo congénito primario como respuesta a un tratamiento integral transfuncional. MATERIAL Y MÉTODOS: Estudio observacional, analítico, longitudinal y prospectivo efectuado en una cohorte (2003-2004) de niños con hipotiroidismo congénito primario tratados en el servicio de Endocrinología y en el Laboratorio de Seguimiento del Neurodesarrollo del Instituto Nacional de Pediatría. Se evaluaron con la Escala de Inteligencia de Wechsler para preescolar y primaria (WPPSI) a los 4, 5 y 6 años. Se obtuvo el coeficiente intelectual total, verbal y ejecutivo por puntuaciones directas, normalizadas y a edades escalares de los procesos cognitivos de atención, memoria y conceptualización. RESULTADOS: Se estudiaron 32 pacientes (72% femeninos) con hipotiroidismo congénito primario [53% por agenesia tiroidea y 47% con ectopia (nódulo sublingual)] en tratamiento con levotiroxina. En el coeficiente intelectual total a los cuatro años, 12% tuvieron puntuaciones limítrofes que persistieron hasta los 6 años y 12% tuvieron deficiencia mental que mejoró a los 6 años. En dos tercios el coeficiente intelectual total fue normal, en ellos, un tercio fue normal brillante o superior según la clasificación de WPPSI. La memoria auditiva y la conceptualización fueron los procesos más afectados en la trayectoria cognitiva. Las edades escalares estimadas fueron inferiores a la edad cronológica. La trayectoria cognitiva a los 6 años se predijo a los 4 años. Los factores de riesgo fueron: agenesia tiroidea, inicio tardío del tratamiento y dosis hormonales altas. Fungieron como factores protectores la participación materna, el nivel alto de estimulación en el hogar y la mejor condición socioeconómica.CONCLUSIONES: La variabilidad de la evolución cognitiva en pacientes con hipotiroidismo congénito permitió caracterizar los factores de riesgo y de protección para definir la intervención cognitiva temprana en niños. PALABRAS CLAVE: Procesos mentales; cognición; niño preescolar; hipotiroidismo congénito; factores de riesgo; factores de protección; factores socioeconómicos.
Quiste esplénico congénito complicado en un niño
Authors: Flores-Pérez Patricia , Hernández Rodríguez María José , Luis Huertas Ana Lourdes , Albi Rodríguez Gustavo 
Published: July 2018

INTRODUCCIÓN: Los quistes esplénicos aislados son raros en niños y potencialmente graves y casi siempre difíciles de diagnosticar. CASO CLÍNICO: Paciente de 5 años, traído a urgencias por fiebre alta, dolor abdominal y vómito. Reporte hematológico: leucocitosis con elevación de reactantes de fase aguda, hemocultivo negativo y coprocultivo positivo para Salmonella serogrupo D. En la radiografía de tórax se objetivó infiltrado basal izquierdo y derrame pleural; en la ecografía abdominal se detectó lesión quística intraesplénica de gran tamaño. Con el diagnóstico de absceso gigante del bazo se pautó tratamiento antibiótico intravenoso y drenajes percutáneos repetidos hasta la intervención quirúrgica definitiva con extirpación quística parcial y fenestración de la cápsula. En el cultivo del absceso creció una Salmonella del mismo serogrupo. El análisis anatomopatológico de la pieza fue compatible con quiste epitelial primario. CONCLUSIONES: Como parte del diagnóstico diferencial de cualquier paciente con signos sugerentes de afectación en el hipocondrio izquierdo deben considerarse los quistes esplénicos. En los últimos años ha habido grandes avances en su tratamiento; en pacientes pediátricos suele ser conservador. PALABRAS CLAVE: Quiste epitelial; absceso esplénico; esplenectomía; niños
Hubungan Pengetahuan Tentang Menstruasi Dengan Sikap dalam Penatalaksanaan Dismenore Primer pada Remaja Putri di SMAN 58 Jakarta
Authors: Wijayanti Anggita , DJ Refirman , Rahayu Sri 
Published: July 2018

Primary dysmenorrhea was experienced by about 72.89 % of young women in Indonesia. Primary dysmenorrhea is a common problem that often reported during their cycle. In other study, there are about 41.2 % of young woman that choose to do nothing in order to reduce their pain. Therefore, knowledge about menstruation has big part for their attitude and practices to reduce and stop the pain caused by dysmenorrhea. This study aims to know the correlation between menstruation knowledge with attitude in the primary dysmenorrhea management. This study was done in November 2016 at SMAN 58 Jakarta, using descriptive method and correlation study survey technique. All of the class XII female student were used as the population, and 90 responden were taken using simple random sampling. The test showed that the data was homogen and have normal distribution. The regression model Y = 30.557 + 2.166X was significant and showed a linear correlation. Correlation coefficient obtained from hypothesis test was 0.762. This result showed a strong and positive correlation between knowledge and attitude about primary dysmenorrhea in female student at SMAN 58 Jakarta
Perbandingan Hasil Belajar Biologi Dengan Menggunakan Model Pembelajaran Kooperatif Script daN Model Pembelajaran Konvensional pada Pokok Bahasan Sistem Eskresi di Kelas VIII SMP Muhammadiyah 11 Tello Makassar
Authors: Putra Nurdin Muh.  Putra N Rizaldi Trias Jaya 
Published: July 2018

In the world of education, improving the quality of learning both in the mastery of materials and learning methods are always strived. One of the efforts that teachers do in improving the quality of teachers is the preparation of various scenarios of learning activities in the classroom. This study aims to determine the comparison of biological learning outcomes by using cooperative learning model script and conventional learning model. This research was conducted at SMP Muhammadiyah 11 Tello Makassar in March until April 2016. The research method used was a Quasy Eksperiment. The research instrument used is the learning result instrument and tested through t-test statistic. The results obtained that t-count value for post-test data in the experimental class of 3.81 while t-table at the level of significance level α 5%, then the value of α designated in table t is 2.00, so obtained t count ≥ t table (3.81 ≥ 2.00 ). This study suggested that cooperative learning scripts can improve students learning outcomes.
Keywords: Cooperative Learning script, Conventional Learning, Learning outcomes
Penerapan Metode Course Review Horay Untuk Meningkatkan Minat Belajar Mahasiswa Prodi Pendidikan Biologi Universitas Bengkulu
Authors: Anggraini Nike 
Published: July 2018

The Purpose of this study is to determine the use of Course Review Horay method for increasing students interest in Vertebrate Zoology courses in Biology Education Department year 2017/2018. This study is a Classroom Action Research, the subjects consisted of 47 students. Data were collected using observation, questionnaires, and documentation. Data obtained were analyzed using descriptive analysis and effect size. This study was conducted in three cycles, each consisting of one meeting during 2 x 50 minutes. Result showed that the Course review horay method could increase students’ interest and the cognitive learning outcomes. Based on questionnaires on students learning interest, at cycle I, data obtained as much as 44,73%, while at cycle II showed an increase in average score by 81,58%. As for the cognitive learning outcomes showed an increase in post-test value in each cycle. The effect size between cycle I and cycle II as much as 0.39 representing small effect size. While the effect size for cycle II and III were 1, 78 which represent high effect size.
Hubungan Status Sosial Ekonomi dengan Tingkat Konsumsi Fast Food pada Remaja
Authors: Halid Musparlin , Sudargo Toto 
Published: July 2018

Modernization has brought negative impact to the public, including in adolescents directly or indirectly, that has directed the diversion a healthy diet. Adolescent are required to more selective in choosing food products consumed. Fast food is food containing high in calories, fat and low fibers. To know the relationship of socioeconomic status with fast food consumption levels among adolescents in Mataram city. The study was observational studies with cross sectional design. The samples as many as 373 students. Dependent variable was the consumption of fast food, and the independent variable was socioeconomic status. The instruments used were questionnaire and FFQ. Data analysis by means of descriptive, and Chi Square test (χ²). Based on the duration per week, there was a relationship between socio-economic status with the western fast food consumption levels (p = 0.00) and local fast food (p = 0.00). Moreover, adolescents with prosperous socioeconomic status have a higher consumption of fast food was very high with a duration of 1 time/week and 2 times/week. While based on the frequency, there was a significant relationship between socioeconomic status with western fast food consumption levels with p = 0.00 and local fast food with p = 0.00 influence of friends was significant with western fast food consumption levels in adolescents (p = 0.002). The habit of eating at home (lunch with p = 0.007) and the effect of mass media was significant with the local fast food consumption levels (p = 0.04).
Adolescents with a prosperous socioeconomic status have greater opportunities to consume fast food than in adolescents with socioeconomic status were less prosperous.
Uji Kadar Zat Warna (β-karoten) Pada Cabe Merah (Capsicum annum. Linn) sebagai Pewarna Alami
Authors: Saadah Miftahus , Nurdiana Nurdiana , Wahyudiati Dwi 
Published: July 2018

Penelitian ini berjudul uji kadar zat warna (β-karoten) pada cabe merah sebagai pewarna alami yanag dilaksanakan mulai dari tanggal 14-15 Desember2015 di Laboratorium Kimia Analitik Fakultas MIPA Unram. Penelitian ini dilakukan untuk mengetahuikadar zat warna (β-karoten) pada cabe merah sebagai pewarna alami. Cabai merah (Capsicum annuum Linn.) merupakan tanaman yang termasuk dalam keluarga Solanaceae.Berdasarkan penelitian yang telah dilakukan untuk mengetahui kadarß-karoten dalam cabe menggunakan satu jenis cabe, yaitu cabe merah, dan tiga sampel dengan berat yang berbeda-beda. Penelitian ini menggunakan metode spektrofotometer. Cabe segar yang telah dihaluskan diekstraksi dengan campuran aseton + n-heksana (20ml) metode maserasi. Setelah proses ekstraksi selesai ditambahkan aseton 9% dalam heksana untuk pembuatan kurva standar. Penetapan kadarß-karoten dilakukan dengan metode spektrofotometer pada panjang gelombang 436 nm. Hasil uji kualitatif menunjukkan bahwa dalam cabe merahbesar (Capsicum annuum Linn.) teridentifikasi adanyaß-karoten. Dari penelitian diperoleh hasil kadar rata-rata ß-karoten pada masing- masing sampel I (5,27), II (5,52) dan III (5,54). Dari hasil pengukuran menggunakan spektrofotometer dapat diketahui bahwa cabe merah banyak mengandung zat warna (ß-karoten). Berdasarkan standar warna yang ada, cabe merah termasuk penghasil ß-karoten dengan kadar yang banyak sehingga bisa digunakan sebagai pewarna alami, akan tetapi pada makanan-makanan tertentu.
Penurunan Total Koloni Bakteri Daging Ayam Pedaging (Gallus domesticus) di Pasar Pagesangan, Kota Mataram Dengan Perlakuan Infusa Daun Salam (Syzygium polyanthum)
Authors: Warsani Ziana , Suhirman Suhirman , Wahyudiati Dwi 
Published: July 2018

Tujuan penelitian ini untuk mengetahui pengaruh konsentrasi infusa daun salam dan waktu pengamatan terhadap penurunan jumlah bakteri pada daging ayam pedaging. Penelitian dilakukan secara eksperimental menggunakan rancangan acak lengkap dengan 3 perlakuan yaitu (konsentrasi infusa 0%, 5%, 10%) dan 3 ulangan. Variabel yang diukur meliputi jumlah bakteri. Data total koloni bakteri dianalisis secara kuantitatif menggunakan ANOVA. Hasil analisis data tersebut menunjukkan bahwa F hitung > Ftabel sehingga Ha diterima artinya perendaman dengan konsentrasi infusa daun salam berpengaruh terhadap penurunan total koloni bakteri pada daging ayam pedaging karna senyawa yang terkandung di dalam daun salam seperti tannin, flavonoid, dll.
IDENTIFIKASI AKUIFER AIR TANAH KOTA PALOPO MENGGUNAKAN METODE GEOLISTRIK TAHANAN JENIS KONFIGURASI SCHLUMBERGER
Authors: Usman Baso , Manrulu Rahma Hi , Nurfalaq Aryadi , Rohayu Emi 
Published: July 2018

Telah dilakukan penelitian untuk mengidentifikasi akuifer air tanah di Kecamatan Sendana Kota Palopo menggunakan metode geolistrik tahanan jenis konfigurasi Schlumberger. Metode geolistrik tahanan jenis merupakan salah satu dari kelompok metode geofisika yang digunakan untuk mempelajari keadaan bawah permukaan dengan cara mempelajari sifat aliran listrik di dalam batuan di bawah permukaan bumi. Metode geolistrik tahanan jenis dilakukan dengan cara menginjeksikan arus listrik ke dalam bumi melalui dua elektroda arus dan potensialnya diukur melalui dua elektroda potensial. Bila arus listrik diinjeksikan ke dalam suatu medium dan diukur beda potensialnya (tegangan), maka nilai hambatan dari medium tersebut dapat diperkirakan. Metode kerja penelitian ini yaitu dengan membuat sebuah lintasan dengan panjang bentangan paling kecil (AB/2) 1,5 hingga panjang bentangan terjauh (AB/2) 200 m, kemudian melakukan pengukuran dengan resistivitymeter, data yang diperoleh kemudian diolah menggunakan software IP2Win untuk mendapatkan gambaran struktur bawah permukaannya. Hasil interpretasi memperlihatkan bahwa akuifer di kecamatan Sendana kota Palopo berupa pasir dan kerikil yang memiliki nilai tahanan jenis 21,6 – 81,3 Ωm pada kedalaman lebih dari 45 m.
Studi Awal Pengaruh Pemberian Asam Boron dan Penembakan Neutron terhadap cell fibroblast dan cell lineKanker Payudara
Authors: Maslebu Giner , Muninggar Jodelin , S. Rondonuwu Ferdy , Trihandaru Suryasatriya , Widarto Widarto , Sardjono Yohannes 
Published: July 2018

Kanker merupakan salah satu penyakit mematikan yang mendapatkan perhatian serius oleh peneliti dan praktisi di bidang kesehatan. Penyakit kanker adalah penyakit yang timbul akibat pertumbuhan tidak normal sel jaringan tubuh yang berubah menjadi sel kanker.Dari berbagai jenis kanker, kasus yang paling banyak terjadi pada kaum perempuan adalah kanker payudara. Teknik pengobatan kanker terus dikembangkan sehingga mampu secara selektif membunuh target sel kanker (cell targeting) dan memberikan efek yang minimal bagi sel sehat di sekitar target. Salah satu teknik pengobatan yang menjanjikan adalah Boron Neutron Captured Teraphy (BNCT). Dalam penelitian ini, sel fibroblast dan sel kanker payudara T47D dipanen pada sumuran setelah diinkubasi selama 16 jam, kemudian diberikan perlakuan asam boron dengan dosis asam boron berjenjang 100 µM, 200 µM, 400 µM.Penembakan neutron diberikan dengan flux sebesar 1010 neutron/cm2s mengggunakan sumber neutron pada fasilitas reaktor Kartini PSTA-Batan terhadap kultur selselama 30 menit. Pada sel fibroblast tingkat kematian sel berkisar antara 2,5-21,212 % setelah pemberian asam Boron dan meningkat menjadi 24,242-71,424 % setelah penembakan neutron. Pada sel kanker payudara T47D tingkat kematian sel berkisar antara 26,761-48,76 % setelah pemberian asam Boron dan meningkat menjadi 36,585-56,25 % setelah penembakan neutron. Hasil penelitian ini menunjukkan ada pengaruh pemberian asam Boron dan penembakan Neutron terhadap tingkat kematian sel.
Model SWAT (Soil and Water Assesment Tool) untuk Analisis Erosi dan Sedimentasi di Catchment Area Sungai Besar Kabupaten Banjar
Authors: Febrianti Indah , Ridwan Ichsan , Nurlina Nurlina 
Published: July 2018

Erosion is a natural process that occurs naturally causing sedimentation in a stream. The transported sediment material can reduce channel capacity and increase the risk of flooding, as happened in the Big River Fishing Area, Karang Intan Subdistrict, Banjar District. Therefore it is necessary to determine the value of erosion and the latest sediment in order to be the basis of consideration of management actions. Watershed management analysis using hydrological model. Soil And Water Assessment Tool (SWAT) is one of the hydrological models that can be used to analyze erosion and sedimentation with parameters such as rainfall data, temperature, land cover, soil and slope. SWAT model simulation using land use data, soil, rainfall and climate data of 2016, the amount of sedimentation and erosion in Catchment Area of large river is 58,48 ton/ha/year and 4,82 ton/ha/year. The level of sedimency in the Catchment Area of the Great River which belongs to very low class is 1635,38 ha, low grade 57,31 ha, middle class 385,21 ha and very high class that is 3.221,48 ha. While the level of erosion that includes very light class of 2334,24 ha, lightweight 2.692.31 ha and middle class area of 272.83 ha.
PENGARUH PENERAPAN METODE QUANTUM LEARNING TERHADAP HASIL BELAJAR MATA PELAJARAN BAHASA INGGRIS
Authors: S. Dwi Martine 
Published: July 2018

The purpose of this study is to find out the effects of quantum learning method to the learning achievement in English subject for the learning participants at the Community Learning Activities Center in Pisangan Lama area, East Jakarta. The study was conducted at Miftahul Jannah Community Learning Activities Center, Pisangan Lama, East Jakarta, for one semester, from August to December 2008. It observed the effects in cognitive, affective, psychomotor aspects to the learning participants of Package C. The method employed was experiment in which the researcher was directly involved. The data were collected from 40 Package C participants randomly selected as the samples out of 70 participants of Grade III. The experiment proved that there are significant effects of quantum learning method to the learning achievementin English subject for the learning participants at Miftahul Jannah Community Learning Activities Center, East Jakarta.
HUBUNGAN PENERAPAN ISO 9001:2000 DAN ORGANISASI BELAJAR TERHADAP KINERJA STAF
Authors: Retnowati Elais , Trisnamansyah Sutaryat 
Published: July 2018

The objective of this research is to analyze the relationship of ISO 9001:2000 implementation with the learning organization and the staff performance in an institution. This study is conducted in P2PNFI Region I Jayagiri and P2PNFI Region II Semarang. The design of development strategies on this research are: (1) conducting the beginning study; (2) creating research instruments; (3) testing instruments; (4) analyzing the validity and reliability instruments; (5) distributing questioners to 94 respondents at P2PNFI Regional I Jayagiri and 84 respondents at P2PNFI Regional II Semarang; (6) collecting questioners; (7) data input and processing; (8) conducting data analyzing and (9) wrapping up the conclusion. The research reveals that (1) there is an increase of the staff performance; (2) a positive correlation between the implementation of ISO 9001:2000 with the staff performance; (3) a positive relationship between the learning organization with the staff performance and (4) a correlation between the implementation of ISO9001:2000 with the performance of staff at two institutions.