bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competitive Affinity Release for Long‐Term Delivery of Antibodies from Hydrogels
Authors: Huynh Vincent , Wylie Ryan G. 
Published: February 2018

AbstractWith increased clinical use of antibodies, long‐term delivery strategies are needed to decrease injection frequency and improve health outcomes. A three‐component drug‐delivery system was developed for competitive affinity release of a streptavidin–antibody conjugate from agarose–desthiobiotin hydrogels via controlled dissolution of sparingly soluble biotin derivatives. The antibody conjugate was localized in the hydrogel through streptavidin–desthiobiotin complexation. Dissolution of sparingly soluble biotin derivatives disrupts streptavidin–desthiobiotin complexation for controlled release of the antibody conjugate. Release was tuned by altering the total biotin derivative concentration without further hydrogel or antibody modification. First‐order tunable release of bioactive Avastin, a therapeutic anti‐VEGF antibody, was demonstrated from a non‐cytotoxic system for over 100 days.
Iron‐Catalyzed Reductive Ethylation of Imines with Ethanol
Authors: Vayer Marie , Morcillo Sara P. , Dupont Jennifer , Gandon Vincent , Bour Christophe 
Published: February 2018

AbstractThe borrowing hydrogen strategy has been applied to the ethylation of imines with an air‐stable iron complex as precatalyst. This approach opens new perspectives in this area as it enables the synthesis of unsymmetric tertiary amines from readily available substrates and ethanol as a C2 building block. A variety of imines bearing electron‐rich aryl or alkyl groups at the nitrogen atom could be efficiently reductively alkylated without the need for molecular hydrogen. The mechanism of this reaction, which shows complete selectivity for ethanol over other alcohols, has been studied experimentally and by means of DFT computations.
Hydrophilic Oligo(lactic acid)s Captured by a Hydrophobic Polyaromatic Cavity in Water
Authors: Kusaba Shunsuke , Yamashina Masahiro , Akita Munetaka , Kikuchi Takashi , Yoshizawa Michito 
Published: February 2018

AbstractBiologically relevant hydrophilic molecules rarely interact with hydrophobic compounds and surfaces in water owing to effective hydration. Nevertheless, herein we report that the hydrophobic cavity of a polyaromatic capsule, formed through coordination‐driven self‐assembly, can encapsulate hydrophilic oligo(lactic acid)s in water with relatively high binding constants (up to Ka=3×105 m−1). X‐ray crystallographic and ITC analyses revealed that the unusual host–guest behavior is caused by enthalpic stabilization through multiple CH–π and hydrogen‐bonding interactions. The polyaromatic cavity stabilizes hydrolyzable cyclic di(lactic acid) and captures tetra(lactic acid) preferentially from a mixture of oligo(lactic acid)s even in water.
Selective Anion Extraction and Recovery Using a FeII4L4 Cage
Authors: Zhang Dawei , Ronson Tanya K. , Mosquera Jesús , Martinez Alexandre , Nitschke Jonathan R. 
Published: February 2018

AbstractSelective anion extraction is useful for the recovery and purification of valuable chemicals, and in the removal of pollutants from the environment. Here we report that FeII4L4 cage 1 is able to extract an equimolar amount of ReO4−, a high‐value anion and a nonradioactive surrogate of TcO4−, from water into nitromethane. Importantly, the extraction was efficiently performed even in the presence of 10 other common anions in water, highlighting the high selectivity of 1 for ReO4−. The extracted guest could be released into water as the cage disassembled in ethyl acetate, and then 1 could be recycled by switching the solvent to acetonitrile. The versatile solubility of the cage also enabled complete extraction of ReO4− (as the tetrabutylammonium salt) from an organic phase into water by using the sulfate salt of 1 as the extractant.
Hierarchischer Aufbau eines verflochtenen M8L16‐Containers
Authors: Bloch Witold M. , Holstein Julian J. , Dittrich Birger , Hiller Wolf , Clever Guido H. 
Published: February 2018

AbstractDie Selbstassemblierung von 8 PdII‐Kationen und 16 Phenanthren‐basierten, verbrückenden Liganden mit einem Bisswinkel von 60° führt zur Bildung einer neuartigen metallosupramolekularen M8L16‐Struktur aus zwei ineinander verflochtenen, D4h‐symmetrischen, fassförmigen Containern. Mit Massenspektrometrie, NMR‐Spektroskopie und Einkristallröntgenstrukturanalyse konnte die Bildung eines sehr großen Catenans mit “Hopf‐Link”‐Topologie nachgewiesen werden, das Kanal‐ähnliche Kavitäten aufweist, in denen sich NO3−‐Anionen befinden. Die Relevanz der Anionen als Templatmoleküle für die Catenierung ergibt sich aus der Beobachtung, dass in einer Mischung von M3L6‐ und M4L8‐Strukturen, die sich in Gegenwart von BF4−‐Anionen bilden, durch Versetzen mit Nitrat eine Strukturänderung zum ineinander verflochtenen Catenan induziert wurde. Das dicht gepackte M8L16‐Catenan fungierte als Vorlage zur Herstellung eines Hexyloxy‐funktionalisierten Analogons, für das eine weiterführende, reversible Aggregation zu vesikulären Überstrukturen beobachtet wurde.
Aqueous‐Phase Synthesis of Mesoporous Zr‐Based MOFs Templated by Amphoteric Surfactants
Authors: Li Ke , Lin Shaoliang , Li Yongsheng , Zhuang Qixin , Gu Jinlou 
Published: February 2018

AbstractZr‐based mesoporous metal–organic frameworks (mesoMOFs) with uniform mesochannels and crystallized microporous framework were constructed in a water‐based system using amphoteric surfactants as templates. Aqueous‐phase synthesis guaranteed the formation of rod‐shaped surfactant micelles. Meanwhile, the carboxylate groups of amphoteric surfactants provided the anchoring to bridge Zr‐oxo clusters and surfactant assemblies. As a result, the directed crystallization of MOFs proceeded around cylindrical micelles and the hierarchical micro‐ and mesostructure was produced. The dimensions of mesopores were easily tailored by changing the alkyl chain length of the applied surfactants. The included surfactant was effectively extracted thanks to the exceptional stability of the obtained Zr‐based mesoMOFs. The almost complete occupation of the mesopore by cytochrome c exemplifies the accessibility of the mesochannels, suggesting the potential applications of the obtained mesoMOFs with bulky molecules.
A Chiral Ligand Assembly That Confers One‐Electron O2 Reduction Activity for a Cu2+‐Selective Metallohydrogel
Authors: Wang Xiaojuan , Wei Chuanwan , Su Ji‐Hu , He Bo , Wen Ge‐Bo , Lin Ying‐Wu , Zhang Yi 
Published: February 2018

AbstractThe design of functional metallohydrogels is attractive but challenging. A rational approach is introduced for designing functional metallohydrogels using chiral ligands, a phenylalanine derivative with a pyridyl group (l/d‐PF). Intriguingly, the as‐prepared metallohydrogel exhibits excellent O2 binding and activating properties. Insights into the O2 binding pathway reveals the presence of a novel [(l+d)‐PF‐Cu3+‐O2−] species, which can efficiently reduce ferric cytochrome c with the reactive O2− by receiving an electron from reductant ascorbic acid. This study provides helpful instructions for developing new artificial systems with specific functions through the effective combination of chiral ligands with metal ions.
Ozonation of aqueous phenol using high‐silica zeolite in an aerated mixing vessel
Authors: Yamamoto Takuji , Iimura Kenji , Satone Hiroshi , Itoh Kazuhiro , Maeda Kouji 
Published: February 2018

AbstractWe examined the degradation of aqueous phenol by ozonation in an aerated mixing vessel, which was combined with a fixed‐bed reactor packed with high‐silica zeolite (HSZ) pellets. Ozone‐containing oxygen gas was introduced as fine bubbles through a sparger placed in the aerated mixing vessel, whereas the aqueous phenol solution was circulated between the vessel and the reactor. Measurements of transient changes in the concentration of both phenol and total organic carbon in the treated solution revealed that the degradation of phenol or total organic carbon by ozonation was enhanced by the presence of HSZ because both phenol and ozone could adsorb on the hydrophobic micropores. As a result of quantitative analysis of the treated solution, it was found that catechol, hydroquinone, humic acid, and maleic acid were the possible reaction intermediates during ozonation of aqueous phenol employing HSZ.
Ion transport properties of porous polybenzimidazole membranes for vanadium redox flow batteries obtained via supercritical drying of swollen polymer films
Authors: Sizov Victor E. , Kondratenko Mikhail S. , Gallyamov Marat O. 
Published: February 2018

ABSTRACTA novel method of membrane preparation for use in vanadium redox flow batteries by preswelling of poly(2,5‐benzimidazole) films in organic solvent followed by supercritical CO2 assisted solvent removal is proposed. Influence of the organic solvent type on the morphology, proton, and vanadyl ion transport properties is studied. The performance of the obtained membranes inside single cells of vanadium redox flow batteries is compared to pristine dense poly(2,5‐benzimidazole) and Nafion 115 membranes. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46262.
Epoxidized vegetable oil and bio‐based materials as PVC plasticizer
Authors: Hosney Hadeel , Nadiem Bassant , Ashour Ibrahim , Mustafa Ibrahim , El‐Shibiny Ayman 
Published: February 2018

ABSTRACTPhthalate esters received a considerable attention owing to its various applications and the harmful health effects resulting from phthalate exposure; thus, finding an alternative to phthalate derivatives became a necessity. Phthalate esters are commonly used as plasticizer in polymer formulation; in particular for poly(vinyl chloride) (PVC) formulation. According to the researches in the last 18 years, epoxidized vegetable oils are one of the alternatives that are strongly encouraged to substitute phthalate esters since they were proven to be valid in various applications, eco‐friendly and sustainable resource. However, most of the production practices for epoxidized vegetable oil are via conventional epoxidation that concentrates on a catalyst that is homogeneous and non‐reusable. This type of catalyst, however, causes several problems later in the process. Therefore, the selective epoxidation of vegetable oils process requires new catalytic systems that are more aligned with the green chemistry principles. This article reviews the harmful health effects associated with the exposure to phthalate esters products, explains the usage of oleochemicals resources as a substitute to phthalate esters and describes different approaches for the epoxidation of vegetable oils. Finally, it draws attention to the usage of epoxy and bio‐based compounds as plasticizers in PVC manufacturing. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46270.
The commercialization and use of exotic baits in recreational fisheries in the north‐western Mediterranean: Environmental and management implications
Authors: Font Toni , Gil João , Lloret Josep 
Published: February 2018

Abstract

Although the use of exotic baits in recreational fisheries represents an increasing environmental threat for Mediterranean marine ecosystems, there is still little information about the commercialization and use of these baits, which makes it difficult to assess their potential impacts and establish specific management measures to tackle the threat that they pose.
This study analyses for the first time the commercialization and use of exotic species in recreational fishing in the Mediterranean, and the associated environmental and management implications. A multiple‐approach design has been used, including: a participatory survey to collect data and perceptions from local retailers and a national bait wholesaler on the environmental impacts of exotic baits; a biological study to identify taxonomically the commercialized bait species; and a bibliographic survey to gather information about the potential environmental impacts of the commercialization and use of exotic baits.
Results showed that, among the 13 different baits sold, only the polychaete group included three exotic species: Perinereis linea, Glycera dibranchiata, and Namalycastis rhodochorde. Furthermore, specimens of the sipunculid Sipunculus nudus, imported from South‐east Asia, should also be considered exotic.
The exotic species P. linea and G. dibranchiata were the two polychaete species most often used by sea anglers. These species were also the most sold by local retailers in the area and by Spain's leading wholesaler.
Overall, anglers and local retailers were not fully aware of the potential negative impacts derived from the use of exotic species, and therefore appropriate management actions, including awareness activities, are discussed to better understand and manage the environmental impacts derived from exotic baits.
Seasonal acoustic occurrence of blue, fin, and North Atlantic right whales in the New York Bight
Authors: Muirhead Charles A. , Warde Ann M. , Biedron Ingrid S. , Nicole Mihnovets A. , Clark Christopher W. , Rice Aaron N. 
Published: February 2018

Abstract

The New York Bight is an extremely busy maritime region, with extensive shipping traffic and commercial fishing activity. It is part of the migratory ranges of a number of cetacean species, and includes threats from ship strikes, noise exposure, and line entanglements. Previous cetacean surveys of the Bight offer limited information on cetacean occurrence and distribution in the region, having been restricted to visual sightings with limited temporal coverage.
A passive acoustic monitoring survey was conducted over a 258‐day period to broaden understanding of the seasonal occurrences of blue (Balaenoptera musculus), fin (Balaenoptera physalus), and North Atlantic right (Eubalaena glacialis) whales during late summer, autumn, winter, and early spring. Stationary acoustic recorders were positioned near the entrance to New York Harbour and as a linear transect extending from Long Island to the continental shelf edge.
Blue, fin, and right whales were detected on 11%, 100%, and 16% of the survey days, respectively. Blue whales were detected offshore during January, February, and March. Fin whales were detected offshore every day, and less often near‐shore. Right whales occurred sporadically during every month, but were most often detected at near‐shore recorders between late February and mid‐May.
Based on the acoustic data alone, it is unclear exactly how these species are using this habitat, although it is clear that they occur in the area longer than was previously thought. Thus, management practices should incorporate this extended seasonal presence to mitigate any effects on the whales from shipping and fishing activities.
Settlement of Ostrea edulis is determined by the availability of hard substrata rather than by its nature: Implications for stock recovery and restoration of the European oyster
Authors: Smyth David , Mahon Anne Marie , Roberts Dai , Kregting Louise 
Published: February 2018

Abstract

Since the collapse of the Ostrea edulis stock in the mid‐1800s the oyster has struggled to re‐establish itself in self‐sustaining assemblages in Europe.
It is now widely recognized that O. edulis is an integral component of a healthy biologically functional benthic environment and, as such, the restoration of wild stocks has become a matter of urgency.
A major limiting factor in O. edulis stock recovery is the availability of suitable substrate material for oyster larvae settlement.
This research re‐examined the larval settlement potential of several naturally occurring in‐situ shell materials (e.g. Mytilus edulis, Modiolus modiolus, O. edulis), with the aim of determining which shell material is the most appropriate for large‐scale restoration projects.
A positive correlation between available shell material and settlement was determined, and analysis using permanova did not identify an attachment preference by O. edulis to any particular shell type.
The findings suggest that if restoration efforts were coordinated with applied hydrodynamic and habitat suitability modelling, in conjunction with naturally occurring shell substrate concentrations, a cost‐effective recovery for O. edulis assemblages in the wild could be achieved.
Dual‐Targeted Selenium Nanoparticles for Synergistic Photothermal Therapy and Chemotherapy of Tumors
Authors: Fang Xueyang , Li Chang'e , Zheng Lan , Yang Fang , Chen Tianfeng 
Published: February 2018

AbstractA combination of chemo‐ and photothermal therapy has emerged as a promising tactic for cancer therapy. However, the intricacy of accurate delivery and the ability to initiate drug release in specific tumor sites remains a challenging puzzle. Hence, to assure that the chemotherapeutic drug and photothermal agent are synchronously delivered to a tumor area for their synergistic effect, dual‐target (RC‐12 and PG‐6 peptides) functionalized selenium nanoparticles loaded with both doxorubicin (DOX) and indocyanine green (ICG) were designed and successfully synthesized. The as‐synthesized nanoparticles exhibited good monodispersity, size stability, and consistent spectral characteristics compared with those of ICG or DOX alone. The nanoparticles underwent self‐immolated cleavage under irradiation from a near‐IR laser and released the loaded drug owing to sufficient hyperthermia. Moreover, the internalized nanoparticles triggered the overproduction of intracellular reactive oxygen species to induce cell apoptosis. Taken together, this study provides a sequentially triggered nanosystem to achieve precise drug delivery by chemo‐photothermal combination.
Folate receptor autoantibodies are prevalent in children diagnosed with autism spectrum disorder, their normal siblings and parents
Authors: Quadros Edward V. , Sequeira Jeffrey M. , Brown W. Ted , Mevs Clifford , Marchi Elaine , Flory Michael , Jenkins Edmund C. , Velinov Milen T. , Cohen Ira L. 
Published: February 2018

Folate deficiency can affect fetal and neonatal brain development Considering the reported association of Folate receptor alpha (FRα) autoantibodies (Abs) with autism and developmental disorders, we sought to confirm this in families of 82 children with ASD, 53 unaffected siblings, 65 fathers, and 70 mothers, along with 52 unrelated normal controls. Overall, 76% of the affected children, 75% of the unaffected siblings, 69% of fathers and 59% of mothers were positive for either blocking or binding Ab, whereas the prevalence of this Ab in the normal controls was 29%. The Ab was highly prevalent in affected families including unaffected siblings. The appearance of these antibodies may have a familial origin but the risk of developing ASD is likely influenced by other mitigating factors since some siblings who had the antibodies were not affected. The antibody response appears heritable with the blocking autoantibody in the parents and affected child increasing the risk of ASD. Autism Res 2018, 11: 707–712. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryFolate is an essential nutrient during fetal and infant development. Autoantibodies against the folate receptor alpha can block folate transport from the mother to the fetus and to the brain in infants. Children diagnosed with autism and their immediate family members were evaluated for the prevalence of folate receptor autoantibodies. The autoantibody was highly prevalent in affected families with similar distribution in parents, normal siblings and affected children. The presence of these antibodies appears to have a familial origin and may contribute to developmental deficits when combined with other factors.
Fish bone peptide promotes osteogenic differentiation of MC3T3‐E1 pre‐osteoblasts through upregulation of MAPKs and Smad pathways activated BMP‐2 receptor
Authors: Heo Seong‐Yeong , Ko Seok‐Chun , Nam Seung Yun , Oh Junghwan , Kim Young‐Mog , Kim Jae‐Il , Kim Namwon , Yi Myunggi , Jung Won‐Kyo 
Published: February 2018

Fish bone, a by‐product of fishery processing, is composed of protein, calcium, and other minerals. The objective of this study was to investigate the effects of a bioactive peptide isolated from the bone of the marine fish, Johnius belengerii, on the osteoblastic differentiation of MC3T3‐E1 pre‐osteoblasts. Post consecutive purification by liquid chromatography, a potent osteogenic peptide, composed of 3 amino acids, Lys‐Ser‐Ala (KSA, MW: 304.17 Da), was identified. The purified peptide promoted cell proliferation, alkaline phosphatase activity, mineral deposition, and expression levels of phenotypic markers of osteoblastic differentiation in MC3T3‐E1 pre‐osteoblast. The purified peptide induced phosphorylation of mitogen‐activated protein kinases, including p38 mitogen‐activated protein kinase, extracellular regulated kinase, and c‐Jun N‐terminal kinase as well as Smads. As attested by molecular modelling study, the purified peptide interacted with the core interface residues in bone morphogenetic protein receptors with high affinity. Thus, the purified peptide could serve as a potential pharmacological substance for controlling bone metabolism.
Site‐Specific Labelling of Native Mammalian Proteins for Single‐Molecule FRET Measurements
Authors: Gust Alexander , Jakob Leonhard , Zeitler Daniela M. , Bruckmann Astrid , Kramm Kevin , Willkomm Sarah , Tinnefeld Philip , Meister Gunter , Grohmann Dina 
Published: February 2018

AbstractHuman cells are complex entities in which molecular recognition and selection are critical for cellular processes often driven by structural changes and dynamic interactions. Biomolecules appear in different chemical states, and modifications, such as phosphorylation, affect their function. Hence, using proteins in their chemically native state in biochemical and biophysical assays is essential. Single‐molecule FRET measurements allow exploration of the structure, function and dynamics of biomolecules but cannot be fully exploited for the human proteome, as a method for the site‐specific coupling of organic dyes into native, non‐recombinant mammalian proteins is lacking. We address this issue showing the site‐specific engineering of fluorescent dyes into human proteins on the basis of bioorthogonal reactions. We show the applicability of the method to study functional and post‐translationally modified proteins on the single‐molecule level, among them the hitherto inaccessible human Argonaute 2.