bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transgenerational epigenetic variance for body weight in meat quails
Authors: Paiva J.T. , de Resende M.D.V. , Resende R.T. , de Oliveira H.R. , Silva H.T. , Caetano G.C. , Lopes P.S. , Silva F.F. 
Published: May 2018

SummaryWe aimed to estimate transgenerational epigenetic variance for body weight using genealogical and phenotypic information in meat quails. Animals were individually weighted from 1 week after hatching, with weight records at 7, 14, 21, 28, 35 and 42 days of age (BW7, BW14, BW21, BW28, BW35 and BW42, respectively). Single‐trait genetic analyses were performed using mixed models with random epigenetic effects. Variance components were estimated by the restricted maximum likelihood method. A grid search for values of autorecursive parameter (λ) ranging from 0 to 0.5 was used in the variance component estimation. This parameter is directly related to the reset coefficient (ν) and the epigenetic coefficient of transmissibility (1‐ν). The epigenetic effect was only significant for BW7. Direct heritability estimates for body weight ranged in magnitude (from 0.15 to 0.26), with the highest estimate for BW7. Epigenetic heritability was 0.10 for BW7, and close to zero for the other body weights. The inclusion of the epigenetic effect in the model helped to explain the residual and non‐Mendelian variability of initial body weight in meat quails.
In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer
Authors: Wei Ran , Wong Janet Pik Ching , Lyu Peng , Xi Xinping , Tong Olivia , Zhang Shu‐Dong , Yuen Hiu Fung , Shirasawa Senji , Kwok Hang Fai 
Published: May 2018

AbstractOsteopontin (OPN) has been shown to promote colorectal cancer (CRC) progression; however, the mechanism of OPN‐induced CRC progression is largely unknown. In this study, we found that OPN overexpression led to enhanced anchorage‐independent growth, cell migration and invasion in KRAS gene mutant cells but to a lesser extent in KRAS wild‐type cells. OPN overexpression also induced PI3K signalling, expression of Snail and Matrix metallopeptidase 9 (MMP9), and suppressed the expression of E‐cadherin in KRAS mutant cells. In human CRC specimens, a high‐level expression of OPN significantly predicted poorer survival in CRC patients and OPN expression was positively correlated with MMP9 expression, and negatively correlated with E‐cadherin expression. Furthermore, we have found that 15 genes were co‐upregulated in OPN highly expression CRC and a list of candidate drugs that may have potential to reverse the secreted phosphoprotein 1 (SPP1) gene signature by connectivity mapping. In summary, OPN is a potential prognostic indicator and therapeutic target for colon cancer.
The role of accounting and the accountancy profession in economic development: A research agenda
Authors: Venter Elmar R. , Gordon Elizabeth A. , Street Donna L. 
Published: May 2018

AbstractA widely held view in the accountancy profession and the donor community is that accounting and the accountancy profession play an essential role in economic development. However, our review of the academic literature finds limited empirical research evidence on the relation between accounting and the accountancy profession and economic development, including specifically whether any such relation is causal, and if so, the direction of the causality. Entities, including those comprising the donor community, policymakers, and professional accountancy organizations (PAOs), need evidence on the question of whether and how the accountancy profession contributes to economic development. Such research could assist donors in evaluating the outcomes of interventions aimed at building the capacity of PAOs in emerging and developing economies and inform future interventions. We summarize the limited academic research addressing the relation between PAOs and economic development and present insights from two roundtables facilitated by the International Association for Accounting Education and Research. We identify research opportunities and research design considerations. We hope our paper will stimulate accounting researchers to advance this literature.
Split face comparison between common concentration vs double dilution of intradermal abobotulinum toxin type A (Dysport) injection for facial lifting in Asians
Authors: Sirithanabadeekul Punyaphat , Lapsomboonsiri Siripan , Rungjang Atiya , Thanasarnaksorn Wilai 
Published: May 2018

SummaryBackgroundThe most efficacious concentration of botulinum toxin for facial lifting is not well established.ObjectiveThis study compared the efficacy of common concentration vs double dilution of intradermal abobotulinum toxin type A (Dysport) injection for facial lifting in Asians.MethodsIn all, 10 women aged 32‐61 years with mild to moderate facial laxity participated in this study. Each patient received one session of intradermal injection of double diluted abobotulinum toxin type A (Dysport) (dilution of 15 mL to give 3.33 units per 0.1 mL) on one side of the face and common concentration (dilution of 7.5 mL to give 6.67 units per 0.1 mL) on the opposite side of the face. Clinical improvement of facial lifting, wrinkling, and subjective satisfaction was evaluated at every visit (baseline, 2, 4, 8, and 12 weeks).ResultsBoth concentrations offered reduction of facial laxity and wrinkles, with no statistical difference. The effects gradually increased and lasted for a minimum 12 weeks with both concentrations.ConclusionCommon concentration and double dilution of intradermal abobotulinum toxin type A (Dysport) injection were effective and safe for facial lifting in Asians. There were no statistically significant differences between the two concentrations.
Mechanism of resveratrol in improving ovarian function in a rat model of premature ovarian insufficiency
Authors: Li Ning , Liu Lili 
Published: May 2018

AbstractAimTo investigate the mechanism of resveratrol treatment in chemically induced premature ovarian insufficiency (POI) in rats.MethodsFive‐week‐old specific pathogen‐free healthy Sprague–Dawley female rats (n = 90) were randomly divided into five groups (n = 18): low‐dose resveratrol (group A), moderate‐dose resveratrol (group B), high‐dose resveratrol (group C), model control group (group D) and blank control group (group E). POI was induced in rats from the resveratrol‐treated groups and the model control group according to observed indexes using a previously established model (oral administration of tripterygium wilfordii polyglycoside tablet 50 mg/kg/day for 14 days). Western blot analysis was performed to compare levels of PI3K, p‐PI3K, Akt, p‐Akt, mTOR, p‐mTOR, Bax, Bcl‐2 and Caspase‐3 in ovarian tissues of each group, and expression of p‐Akt, p‐mTOR, Bax, Bcl‐2 and Caspase‐3 was also evaluated by immunohistochemistry. Serum levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were determined using enzyme‐linked immunosorbent assay.ResultsCompared with controls, we found that serum MDA decreased and SOD increased in resveratrol‐treated groups. In addition, we found increased expression of p‐PI3K, p‐Akt, p‐mTOR and Bcl‐2, and decreased expression of Bax and Caspase‐3 were observed in ovarian tissues of treated rats with POI. There was reduced ovarian function in POI rats compared with rats from the blank control group.ConclusionResveratrol reduced oxidative stress and inhibited apoptosis in granulosa cells by activating the PI3K/Akt/mTOR signaling pathway in a rat model of POI.
Immune checkpoints indoleamine 2,3‐dioxygenase 1 and programmed death‐ligand 1 in oral mucosal dysplasia
Authors: Sieviläinen Meri , Passador‐Santos Fabricio , Almahmoudi Rabeia , Christopher Solomon , Siponen Maria , Toppila‐Salmi Sanna , Salo Tuula , Al‐Samadi Ahmed 
Published: May 2018

BackgroundOral mucosal dysplasia is a histologic feature of potentially malignant disorders that is associated with the risk of transformation to carcinoma. Dysplastic cells use many strategies during their transformation to cancer, including escape from the immune mediated destruction. We hypothesized that adaptive immunity is inhibited by activation of distinct immune checkpoint molecules, such as indoleamine 2,3‐dioxygenase 1 (IDO1) and programmed death‐ligand 1 (PD‐L1).MethodsWe collected 63 oral dysplasia samples from 47 patients. Nine biopsies from alveolar mucosa were taken during wisdom teeth extractions were used as healthy controls. Tissue samples were stained and scored for IDO1 and PD‐L1. Additionally, dysplasia grades and inflammatory cell infiltration were evaluated. Eight patients were followed up to 36 months to evaluate dysplasia progression, inflammation, and immune checkpoint molecules expression.ResultsDysplastic epithelium had significantly lower IDO1 expression than that of healthy controls. PD‐L1 positive cells in the lamina propria were mainly in dysplastic samples and seldom in healthy controls. Dysplasia grade was associated negatively with epithelium IDO1 and positively with IDO1 and PD‐L1 expression in the lamina propria. There was a positive association between dysplasia grade and level of inflammatory cell infiltration. During follow‐up, dysplasia grade, inflammatory cell infiltration, and the immune checkpoint expression fluctuated over time.ConclusionsImmune checkpoint molecules IDO1 and PD‐L1 are modulated during oral epithelial dysplastic changes, and their expression is associated with inflammatory cell infiltration in the lamina propria. As immune checkpoint molecules expression fluctuates over time, these molecules are not useful as biomarkers for oral mucosal dysplasia progression.
Beyond Consumptive Solidarity: An Aesthetic Response to Human Trafficking
Authors: Flores Nichole 
Published: May 2018

AbstractA disturbing economic reality confronts consumers today: thousands of farm workers are enslaved in U.S. agricultural fields, forced to work without pay amid deplorable conditions and under the constant threat of violence. If structural economic injustices perpetuate modern‐day agricultural slavery, then it is necessary to promote consumer practices that resist these abusive dynamics. But a consumption‐oriented strategy does not necessarily restore either personal agency or communal relations damaged by agricultural trafficking. This essay proposes a framework for aesthetic solidarity that cultivates affective bonds necessary for building communities of resistance characterized by mutuality, equality, and participation.
The effects of biodegradable poly(lactic‐co‐glycolic acid)‐based microspheres loaded with quercetin on stemness, viability and osteogenic differentiation potential of stem cell spheroids
Authors: Lee H. , Nguyen T. T. , Kim M. , Jeong J.‐H. , Park J.‐B. 
Published: May 2018

ObjectiveQuercetin has been reported to exert many beneficial effects on the protection against various diseases, such as diabetes, cancer, and inflammation. The aim of this study is to evaluate the potential osteogenic differentiation ability of mesenchymal stem cells in the presence of quercetin.Material and MethodsQuercetin‐loaded poly(lactic‐co‐glycolic acid) microspheres were prepared using an electrospraying technique. Characterization of the microspheres was evaluated with a scanning electron microscope and release profile. Three‐dimensional cell spheroids were fabricated using silicon elastomer‐based concave microwells. Qualitative results of cellular viability were seen under a confocal microscope, and quantitative cellular viability was evaluated using the Cell Counting Kit‐8 assay. The alkaline phosphatase activity and Alizarin Red S staining were performed. A quantitative real‐time polymerase chain reaction and a western blot analysis were performed.ResultsSpheroids were well formed irrespective of quercetin concentration. Most of the cells in spheroids emitted green fluorescence, and the morphology was round without significant changes. The application of quercetin‐loaded microspheres produced a significant increase in the alkaline phosphatase activity. The real‐time polymerase chain reaction results showed a significant increase in Runx2, and western blot results showed higher expression of Runx2 protein expression.ConclusionBiodegradable microspheres loaded with quercetin produced prolonged release profiles with increased mineralization. Microspheres loaded with quercetin can be used for the enhancement of osteoblastic differentiation in cell therapy.
Multisite Replication in Second Language Acquisition Research: Attention to Form During Listening and Reading Comprehension
Authors: Morgan‐Short Kara , Marsden Emma , Heil Jeanne , Issa II Bernard I. , Leow Ronald P. , Mikhaylova Anna , Mikołajczak Sylwia , Moreno Nina , Slabakova Roumyana , Szudarski Paweł 
Published: May 2018

AbstractWe conducted a multisite replication study with aspects of preregistration in order to explore the feasibility of such an approach in second language (L2) research. To this end, we addressed open questions in a line of research that has examined whether having learners attend to form while reading or listening to a L2 passage interferes with comprehension. Our results are consistent with findings from the specific paradigm that we replicated in that no effects on comprehension were detected in analyses conducted over all sites. However, further investigation is warranted due to site‐specific effects and methodological limitations. We found all aspects of the multisite registered replication approach to be useful although the registration component itself appeared to be an especially feasible and valuable first step toward increasing the robustness and generalizability of findings in our field.Open PracticesThis article has been awarded Open Data, Open Materials, and Preregistered Research Design badges. The following information is publicly accessible via the Open Science Framework: registered materials and protocol (https://osf.io/tvuer), registered data entry template (https://osf.io/d5s2t), open data (https://osf.io/vwytd), and open analysis (https://osf.io/nz3su). Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/tvyxz/wiki.
The role of institutions of higher education in teaching Indigenous languages: Ichishkíin and Chinuk Wawa
Authors: Underriner Janne , Jansen Joana 
Published: May 2018

AbstractSince 2008, Ichishkíin and Chinuk Wawa language courses have been offered at the University of Oregon (UO) and Lane Community College in Eugene, Oregon. These languages are Indigenous to peoples of present day Oregon and Washington. Both courses resulted through partnerships developed at the Northwest Indian Language Institute (NILI). This article describes the development of the courses and their continued impact. Both language programs embody collaborative partnering with elders, Tribal language programs, other institutions, and teachers. Both have created curricular materials that are used by Tribal programs and K‐12 schools and have mentored students to become language teachers. We propose that teaching local endangered languages in university settings enriches students' academic experiences, supports language revitalization, addresses issues of human and linguistic rights, and strengthens institutions by incorporating Indigenous viewpoints. Academic institutions that once contributed to the loss of Indigenous languages now have an opportunity and obligation to revitalize and maintain them.
Lake Chivero (Zimbabwe) and its climatic environment
Authors: Magadza C. H. D. 
Published: May 2018

AbstractThe mean temperatures and mean maximum temperatures in Lake Chivero indicate a warming trend, which is not evident in mean minimum temperatures. The mean annual precipitation also exhibits a declining trend, as does the Manyame River flow trend. The relation between run‐off, river flow and precipitation indicate a discontinuous trend at a piecewise regression breakpoint of 998 mm precipitation. Above the breakpoint, the river flow is related exponentially with precipitation, while the run‐off relationship is linear, although with a low R2 value. Below the breakpoint, both the run‐off and river flow exhibit a low variance accountability. Considered within the context of the IPCC findings of a subcontinent warming faster than the rest of the southern hemisphere, along with declining precipitation, these data suggest an uncertain water supply security for the City of Harare and its satellite settlements. The detectable warming of the lake, taken together with observations in Lake Kariba, also suggests an ecological shift that could be dominated by a shift to a permanent cyanobacteria‐dominated ecosystem, which is currently dominated by Microcystis and Anabaena species.
Citizen science monitoring of marine protected areas: Case studies and recommendations for integration into monitoring programs
Authors: Freiwald Jan , Meyer Ryan , Caselle Jennifer E. , Blanchette Carol A. , Hovel Kevin , Neilson Doug , Dugan Jenifer , Altstatt Jessica , Nielsen Karina , Bursek Julie 
Published: May 2018

AbstractEcosystem‐based management and conservation approaches such as marine protected areas (MPAs) require large amounts of ecological data to be implemented and adaptively managed. Recently, many citizen science programs have endeavored to help provide these much‐needed data. Implementation of MPAs under the Marine Life Protection Act (MLPA) Initiative in Southern California was followed by a monitoring program to establish a comprehensive baseline of the ecological conditions of several marine ecosystems at the time of MPA implementation. This baseline monitoring consortium involved several citizen science monitoring programs alongside more traditional academic monitoring programs, creating an opportunity to evaluate the potential for citizen scientists to become more involved in future long‐term monitoring efforts. We investigated different citizen science models, their program goals, and contributions to MPA baseline monitoring, including their respective monitoring protocols and data quality assurance measures, in the context of the goals of the MLPA baseline monitoring program. We focused on three very different case studies: (i) commercial fishermen and other volunteers collaborating with researchers to study the California spiny lobster, (ii) volunteer divers monitoring rocky reefs with the Reef Check California (RCCA) program and (iii) middle and high school students monitoring the inter‐tidal life of rocky shore and sandy beach ecosystems with the National Marine Sanctuaries’ Long‐term Monitoring Program and Experiential Training for Students (LiMPETS) program. We elucidate capacities and potential of citizen science approaches for MPA baseline monitoring and for building capacity towards sustainable long‐term monitoring of MPAs. Results from this study will be relevant and timely as the monitoring of California's MPAs transitions from baseline to long‐term monitoring, and as citizen science continues to become more prevalent in California and elsewhere.
Development of a biological condition assessment index for shallow, subtidal rocky reefs in Southern California, USA
Authors: Coates Julia H. , Schiff Kenneth , Mazor Raphael D. , Pondella Daniel J. , Schaffner Rebecca , Whiteman Elizabeth 
Published: May 2018

AbstractQuantitative biological assessment indices overcome many of the challenges faced when trying to convey the status or trends of complex biological communities with large natural variability, particularly when attempting to evaluate the impacts from human influences. In this paper, we developed a biological condition index for shallow (<30 m) rocky reefs of the Southern California Bight, evaluated its ability to distinguish healthy from stressed sites, and then applied the index by examining relative correlations with fishing and water quality as ecosystem stressors. We utilized a multivariate, predictive index based on the ratio of observed‐to‐expected taxa (O/E). O/E indices are relatively common in freshwater environments, but rarely utilized in marine systems and never before applied to rocky reefs. Based on expectations drawn from region‐wide reference reefs with the least fishing or water quality stress, the O/E index predicts expected taxa at a new site based on environmental factors such as sea surface temperature, reef area, and slope, among others. The observed taxa at that site are then compared to the predicted taxa to generate index scores; values near unity indicate intact, reference‐like communities. Overall, the accuracy of the index was high, with minimal bias, and precision exceeded the performance of an index based on null models (i.e., indices that did not account for natural gradients). The mean index score was significantly higher among reference sites than stressed sites; however, sensitivity was low, as 84% of stressed sites had scores within the range of reference sites. Ultimately, fishing pressure was more correlated with changes in index scores from the non‐reference data set than was water quality pressure. This study demonstrates that a multivariate predictive index is feasible in rocky reef assessment and illuminates additional investigative work to continue to advance index development.
Can nearshore seabirds detect variability in juvenile fish distribution at scales relevant to managing marine protected areas?
Authors: Robinette Daniel P. , Howar Julie , Claisse Jeremy T. , Caselle Jennifer E. 
Published: May 2018

AbstractJuvenile recruitment is an important determinant of change within marine protected areas (MPAs). Understanding spatio‐temporal variability in recruitment rates will help managers set realistic expectations for rates of population and community level change within individual MPAs. Here we ask whether seabird foraging rates can be used as a proxy for juvenile fish recruitment at spatial scales relevant to MPA management. We investigated the foraging rates of six piscivorous seabirds inside and outside of three island and four mainland MPAs in Southern California and compared these rates to estimates of juvenile fish density from kelp forest surveys conducted at the same sites during the same 2 years (2012 and 2013). Juvenile fish communities at island and mainland sites were dominated by three families, Embiotocidae, Labridae and Pomacentridae, in both years. Additionally, there was an influx of young‐of‐the‐year rockfishes (family Sebastidae) at most sites in 2013. Seabird and fish distributions were similar at the regional (approximately 15–30 km) scale, but less similar at the site‐specific scale. Site‐specific differences reflected differences in the diet and foraging habits of individual seabird species. While fish surveys were specific to the kelp forest habitat, seabirds were sampling multiple habitats (i.e. multiple water depths over multiple bottom substrates) within a given site. Our results suggest that integrating seabird data with data on juvenile fish abundance can produce a more holistic index to proxy spatio‐temporal variability in juvenile fish recruitment. In other words, seabird studies can provide additional information not captured by fish surveys and help resource managers better understand local patterns of fish recruitment at the community level. This will help resource managers establish realistic expectations for how quickly fish populations should change within individual MPAs.