bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Highly Potent Os@Au‐TPA Coordination Structure‐Based Sonosensitizer for Tumor Sono‐Immunotherapies
Authors: Xie Pengfei , Rong Xiao , Qin Xuelian , Li Min , Zuo Yan , Liu Bingjie , Cao Sujiao , Yang Jie , Qiu Li 
Published: November 2024

AbstractUltrasound (US) becomes an appealing modality for stimulating or amplifying immune responses during cancer therapy, which is also termed sono‐immunotherapy. However, the clinical prospect has not been fully realized due to the scarcity of efficient sonosensitizers. Herein, for the first time a novel Os‐doped Au‐tri(pyridin‐4‐yl) amine coordination structure (Os@Au‐TPA)‐based sonosensitizer is originally designed and synthesized for sono‐immunotherapy of breast‐metastasized tumors. Impressively, Os@Au‐TPA shows much higher US‐mediated 1O2‐producing activity than Au‐TPA as well as the other traditional sonosensitizers, for example, ≈41.6 folds to ce6, 19.5 times to Protoporphyrin IX (PpIX), 12.0 to Indocyanine Green (ICG), and 11.1 to Iron phthalocyanine (Pc(Fe)). The Os@Au‐TPA can not only generate abundant ROS upon US irradiation to implement sonodynamic therapy (SDT), stimulating cell apoptosis and further immunogenic cell death, but can also generate O2 to alleviate hypoxia to promote the polarization of M2 to M1 macrophages to enhance tumor immunogenicity. As a result, when combined with PD‐L1 antibody, it remodels the immunosuppressive tumor microenvironment, achieves concurrent sonodynamic‐triggered immune activation, and eradicates both the original and distant‐metastasized tumors efficiently. This work not only provides a new strategy to construct potent sonosensitizers from pyridine‐metal coordination structures but also proves that sonosensitizers with high performance are crucial in boosting cancer sono‐immunotherapy.
Nanocellulose‐Based Interfacial Solar Evaporator: Integrating Sustainable Materials and Micro‐/Nano‐Architectures for Solar Desalination
Authors: Ko Youngsang , Lee Suji , Jang Jieun , Kwon Goomin , Lee Kangyun , Jeon Youngho , Lee Ajeong , Park Teahoon , Kim Jeonghun , You Jungmok 
Published: November 2024

AbstractClean‐water harvesting through solar interfacial evaporation technology has recently emerged as a strategy for resolving global water scarcity. In this study, rapid carbon‐dioxide‐laser‐induced carbonization and facile ice‐templating is employed to construct a cellulose‐based solar evaporator bearing a hybrid multi‐layer micro‐/nano‐architecture (i.e., a laser‐induced carbon (LC) nanostructure and a cellulose aerogel (CA) nano/microstructure). The LC exhibits a light‐absorbing/photothermal nanoporous carbon structure that offers high light absorption and multiple light scattering. Additionally, the CA exhibits numerous nanopores and unidirectional microchannels that facilitate rapid water transport via capillary action. This hybrid LC/CA micro‐/nano‐architecture enabled rapid vapor generation with an average water evaporation rate (ν) of 1.62 kg m−2 h−1 and an evaporation efficiency (η) of 66.6%. To further enhance the evaporation performance, a polydimethylsiloxane (PDMS) layer is coated onto the side of the LC/CA evaporator to increase its floatability in the simulated water; ν and η of the PDMS‐coated LC/CA evaporator (LC/CA/PDMS) increased to 1.9 kg m−2 h−1 and 83.8%, respectively. Additionally, the LC/CA/PDMS evaporator exhibited a high ν value of 1.68 kg m−2 h−1 in simulated seawater, originating from excellent resistance to salt accumulation via its self‐cleaning ability. Furthermore, the solar evaporator exhibited scalability for fabrication as well as biodegradable properties.
Integration of Sensory Memory Process Display System for Gait Recognition
Authors: Sun Tao , Qi Meng , Li Qing‐Xiu , Li Hang‐Fei , Feng Zhi‐Peng , Xu Run‐Ze , Zhou You , Wen Yu , Li Gui‐Jun , Zhou Ye , Han Su‐Ting 
Published: November 2024

AbstractGait is among the most dependable, accurate, and secure methods of biometric identification. However, high power consumption and low computing capability are two major obstacles on wearable sensors‐based gait recognition system. In this work, an integrated system is reported combining a triboelectric nanogenerator (TENG), a memristor (Ag/HfOx/Pt), and perovskite‐based multicolor LEDs (PMCLED) for the visualization and recognition of foot patterns through signal‐on‐none and multi‐wavelength on‐device preprocessing. The flexible TENG acts as a sensory receptor, generating voltage based on the duration and intensity of pressure, which in turn promotes voltage‐triggered synaptic plasticity in the memristor. The PMCLED, with its threshold switching and multi‐wavelength emission characteristics, enables nonlinear filtering and amplification of the synaptic signal from the memristor, resulting in a simplified system design and reduced background noise. Additionally, the effectiveness of on‐device preprocessing is validated based on a 5 × 5 array of integrated devices and software‐built neural network for foot pattern visualization and recognition. The proposed system is able to recognize the on‐device preprocessed images with high accuracy, indicating great potentials in both healthcare monitoring and human‐machine interaction.
Covalent Organic Framework‐Enhanced Metal Halide Perovskites for Selective and Sensitive Gas Sensing
Authors: Ye Wen , Li Meng , Li Guixiang , Jiang Lihua , Tian Shun , Dong Shihong , Xu Qingfeng , Chen Dongyun , Nazeeruddin Mohammad Khaja , Dyson Paul J. , Abate Antonio , Lu Jian‐Mei 
Published: November 2024

AbstractSolution‐processed lead‐free halide perovskite gas sensors possess low gas detection limits, offering promising alternatives to traditional metal oxide chemiresistors. However, halide perovskite chemiresistors often suffer from poor selectivity and durability due to a lack of coordinatively unsaturated surface metal ions and their sensitivity to humidity. To address these issues, a general strategy is presented in which the Cs2PdBr6 perovskite surface is coated with covalent organic framework (COF) to provide hybrid sensor materials that are highly sensitive to specific gases and demonstrate excellent stability under real‐working conditions. The hybrid chemiresistors demonstrate high sensitivity and controllable selectivity toward NO2 or NH3 gases. Specifically, TAPB–PDA@Cs2PdBr6 achieves a detection limit of 10 ppb for NO2, the lowest value reported for a perovskite‐based gas sensor, maintaining its performance after continuous exposure to ambient air for several weeks. In contrast, COF‐5@Cs2PdBr6 shows high selectivity to NH3 and has a detection limit of 40 ppb. Structural and spectroscopic characterization combined with mechanistic studies provide molecular‐level insights into the outstanding properties of these new hybrid sensor materials, which set a new benchmark in the field, i.e., surpassing the selectivity and sensitivity of conventional halide perovskite sensors.
Size‐Tunable Boron Nanoreactors for Boron Neutron Capture Synergistic Chemodynamic Therapy of Tumor
Authors: Li Lin , Zhao Qian , Chen Zhiqing , Zhao Zican , Du Baojie , Wang Mixue , Bai Peirong , Wang Xiaozhe , Ren Xiaofeng , Li Liping , Zhang Ruiping 
Published: November 2024

AbstractBoron neutron capture therapy (BNCT) stands out as a noninvasive potential modality for invasive malignant tumors, with boron drugs playing a crucial role in its efficacy. Nevertheless, the development of boron drugs with biodegradability, as well as high permeability and retention effects, continues to present significant challenges. Here, we fabricate a size‐tunable boron nanoreactor (TBNR) via assembling boron nitride quantum dots (BNQDs) and Fe3+ for tumor BNCT and chemodynamic (CDT) synergistic treatment. The obtained TBNR with an appropriate size exhibits superior tumor accumulation and retention. Upon stimulation by the tumor microenvironment (TME), the contained Fe3+ undergo redox reactions with glutathione (GSH) to produce Fe2+ Fenton reagents, which in turn activate CDT function and simultaneously induce TBNR depolymerization. Subsequently, the released ultrasmall BNQDs exhibit intra‐deep penetration characteristic and are fully enriched at the tumor site. The in vivo experiments reveal that TBNR possesses excellent biocompatibility and superior synergistic anti‐tumor ability post neutron irradiation, resulting in significant shrinkage of subcutaneous 4T1 tumors. Moreover, the TBNR‐mediated BNCT has triggered an obvious immune response, which contributes to the long‐term suppression of tumors after neutron irradiation. To conclude, this study provides a new approach for constructing more efficient versatile nanocarriers for BNCT‐induced combination cancer therapies.
Boosting Tumor Accumulation of Phthalocyanine through Sialylation Engineering for Superior Cancer Phototherapy
Authors: Li Jian , Wang Tingting , Li Cijuan , Zhang Xun , Li Jingchao , Zhang Dongsheng , Zhang Yafei , Yang Jun , Su Xinhui , Liu Nian 
Published: November 2024

AbstractPhthalocyanines (Pcs) are widely developed in cancer phototherapy due to their definite chemical structure and tunable photosensitivity. However, their in vivo application is hampered by low water solubility and non‐specific biodistribution. Here,a strategy of sialylation‐modulation is developed for the first time to highly improve the bioavailability of Pcs. The sialylated Pcs (ZnPc‐4SA) not only has good hydrophilicity, but also can self‐assemble into nanoparticles (ZnPc‐4SA NPs). These nanoformulations retain the excellent photophysical properties of Pcs, which in turn reflects excellent optoacoustic and phototherapeutic properties. Importantly, ZnPc‐4SA NPs exhibit boosted tumor accumulation due to the passive targeting and sialic acid‐mediated E‐selectin targeting. Besides, the phototoxicity of ZnPc‐4SA NPs can effectively trigger cell apoptosis and tumor elimination upon laser irradiation. Therefore, sialylation engineering strategy provides a new option for hydrophobic drugs modification with enhanced tumor theranostics.
Spintronic Pathways in a Nonconjugated Radical Polymer Glass
Authors: Tahir Hamas , Flores‐Hansen Carsten , Hsu Sheng‐Ning , Liang Zihao , Naga Jayant , Dilley Neil R. , Savoie Brett M. , Boudouris Bryan W. 
Published: November 2024

AbstractRadical chemistries have attracted burgeoning attention due to their intriguing technological applications in organic electronics, optoelectronics, and magneto‐responsive systems. However, the potential of these magnetically active glassy polymers to transport spin‐selective currents has not been demonstrated. Here, the spin‐transport characteristics of the radical polymer poly(4‐glycidyloxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl) (PTEO) allow for sustained spin‐selective currents when incorporated into typical device geometries with magnetically polarized electrodes. Annealing thin films of PTEO above its glass transition temperature results in a giant magnetoresistance effect (i.e., an MR of ≈80%) at 4 K. Additionally, ferromagnetic resonance spin‐pumping results in a relatively large effective spin‐mixing conductance of 1.18 × 1019 m−2 at the NiFe/PTEO interface. Due to the large spin‐density and radical‐radical exchange interactions, there is effective propagation of pure spin currents through PTEO in the NiFe/PTEO/Pd multilayer devices. This results in the transport of spin current over long distances with a spin diffusion length of 90.4 nm. The spin diffusion length and spin mixing conductance values surpass those reported in inorganic and metallic systems and are comparable to conventional doped conjugated polymers. This is the first example of spin transport in a nonconjugated radical polymer, and these findings underscore the promising spin‐transporting potential of radical polymers.
Mesoporous Acridinium‐Based Covalent Organic Framework for Long‐lived Charge‐Separated Exciton Mediated Photocatalytic [4+2] Annulation
Authors: Nath Ipsita , Chakraborty Jeet , Rawat Kuber Singh , Ji Yanwei , Wang Rundong , Molkens Korneel , De Geyter Nathalie , Morent Rino , Van Speybroeck Veronique , Geiregat Pieter , Van Der Voort Pascal 
Published: November 2024

AbstractReadily tuneable porosity and redox properties of covalent organic frameworks (COFs) result in highly customizable photocatalysts featuring extended electronic delocalization. However, fast charge recombination in COFs severely limits their photocatalytic activities. Herein a new mode of COF photocatalyst design strategy to introduce systematic trap states is programmed, which aids the formation and stabilization of long‐lived charge‐separated excitons. Installing cationic acridinium functionality in a pristine electron‐rich triphenylamine COF via postsynthetic modification resulted in a semiconducting photocatalytic donor–acceptor dyad network that performed rapid and efficient oxidative Diels‐Alder type [4+2] annulation of styrenes and alkynes to fused aromatic compounds under the atmospheric condition in good to excellent yields. Large mesopores of ≈4 nm diameter ensured efficient mass flow within the COF channel. It is confirmed that the catalytic performance of COF originates from the ultra‐stable charge‐separated excitons of 1.9 nm diameter with no apparent radiative charge‐recombination pathway, endorsing almost a million times better photo‐response and catalysis than the state‐of‐the‐art.
Generating High‐Fidelity Structured Light Fields Through an Ultrathin Multimode Fiber Using Phase Retrieval
Authors: Mouthaan Ralf , Christopher Peter J. , Dholakia Kishan , Gordon George S. D. , Wilkinson Timothy , Euser Tijmen G. 
Published: November 2024

AbstractLight transmission through a multimode fiber (MMF) has gained major importance for imaging and manipulation. The majority of phase retrieval algorithms used for a MMF implicitly assume light propagation to be described by a unitary operation, yet the transmission matrix of a multimode fiber is inherently non‐unitary. It is demonstrated that this erroneous assumption can impede the performance of many commonly used MMF phase retrieval algorithms and demonstrate that the weighted Yang–Gu algorithm outperforms other phase retrieval algorithms in this scenario. Once accounted for, the non‐unitary property of the transmission matrix can be leveraged to generate intricate intensity and phase patterns at the output of the fiber, and shape specific output fields. This is experimentally demonstrated by generating Laguerre–Gaussian beams that carry orbital angular momentum, and by forming images in planes offset from the distal end of the fiber facet.
Enhancing Hydrophobicity in Mn4+‐Doped Organometallic Fluoride with High Quantum Efficiency through the Utilization of Trimethylsulfoxide Cation
Authors: Zhan Yuxin , Cai Peiqing , Li Boya , Pu Xipeng , Wang Guanghua , Zhang Jie , Liu Zugang 
Published: November 2024

AbstractMn4+‐doped red fluoride phosphors are crucial in white light illumination and display technologies due to their broad color gamut, high color purity, and cost‐effective production. This study introduces a novel Mn4+‐doped trimethylsulfoxonium hexafluorotitanate ((TMSO)2TiF6) organometallic fluoride phosphor. Crystallographic analysis via single‐crystal X‐ray diffraction reveals a cubic structure with space group Pa‐3. The synthesized material exhibits a characteristic Mn4+ narrow‐band red emission peak at 633 nm, with a photoluminescent quantum yield (PLQY) of 73%. Furthermore, compared to similar materials, this phosphor exhibits relatively better water resistance due to the introduction of TMSO+ cations, retaining 30% of its initial PL intensity after 72 hours of water immersion. In addition, the material exhibits anti‐Stokes emission by pumping the 2E Stokes sideband state directly, broadening its potential applications as luminescent cooling materials. The research results highlight the significant advantages of Mn4+‐doped phosphors, including high color purity, short excited state lifetimes, and relatively strong weather resistance. These findings provide a solid foundation and feasible pathway for the development of ultra‐wide color gamut displays with enhanced stability.
Deficiency of FABP7 Triggers Premature Neural Differentiation in Idiopathic Normocephalic Autism Organoids
Authors: Han Xiao , He Yuanlin , Wang Yuanhao , Hu Wenzhu , Chu Chu , Huang Lei , Hong Yuan , Han Lu , Zhang Xu , Gao Yao , Lin Yuan , Ma Hongxia , Shen Hongbing , Ke Xiaoyan , Liu Yan , Hu Zhibin 
Published: November 2024

AbstractAutism spectrum disorder (ASD), which is caused by heterogeneous genetic and environmental factors, is characterized by diverse clinical phenotypes linked to distinct pathological mechanisms. ASD individuals with a shared clinical phenotype might contribute to revealing the molecular mechanism underlying ASD progression. Here, it is generated induced pluripotent stem cell (iPSC)‐derived cerebral organoids from normocephalic individuals with ASD in a prospective birth cohort with a shared clinical diagnosis. Multiple cell lines and time series scRNA‐seq combined with a histomorphological analysis revealed premature neural differentiation of neural stem cells (NSCs) and decreased expression of Fatty acid binding protein 7 (FABP7) in ASD organoids. It is subsequently revealed alterations in the phosphorylation levels of Mitogen‐Activated Protein Kinase Kinase 1/2 (MEK1/2), which are downstream of FABP7, and the regulation of the FABP7/MEK pathway reversed improper neural differentiation in the ASD organoids. Moreover, both Fabp7‐knockdown and MEK2‐overexpressing mice exhibited repetitive stereotyped behaviors and social defects relevant to autism. This study reveals the role of the FABP7/MEK pathway in abnormal NSC differentiation in normocephalic individuals with ASD, which might provide a promising therapeutic target for ASD treatment.
Bioinspired Microhinged Actuators for Active Mechanism‐Based Metamaterials
Authors: Cao Zi‐Yi , Sai Huayang , Wang Weiwei , Yang Kai‐Cheng , Wang Linlin , Lv Pengyu , Duan Huiling , Huang Tian‐Yun 
Published: November 2024

AbstractMechanism‐based metamaterials, comprising rigid elements interconnected by flexible hinges, possess the potential to develop intelligent micromachines with programmable motility and morphology. However, the absence of efficient microactuators has constrained the ability to achieve multimodal locomotion and active shape‐morphing behaviors at the micro and nanoscale. In this study, inspiration from the flight mechanisms of tiny insects is drawn to develop a biomimetic microhinged actuator by integrating compliant mechanisms with soft hydrogel muscle. A Pseudo‐Rigid‐Body mechanical model is introduced to analyze structural deformation, demonstrating that this hydrogel‐based microactuator can undergo significant folding while maintaining high structural stiffness. Furthermore, multiple microhinged actuators are combined to facilitate folding in multiple degrees of freedom and arbitrary directions. Fabricated by a multi‐step four‐dimensional (4D) direct laser writing technique, the microhinged actuators are integrated into 2D and 3D metamaterials enabling programable shape morphing. Additionally, micro‐kirigami with photonic structures is demonstrated to show the pattern transforming actuated by the microhinges. This bioinspired design approach opens new avenues for the development of active mechanism‐based metamaterials capable of intricate shape‐morphing behaviors.
A Single‐Cell Atlas of Crab Ovary Provides New Insights Into Oogenesis in Crustaceans
Authors: Lu Li , Wang Tao , Liu An , Ye Haihui 
Published: November 2024

AbstractOogenesis is crucial for sexual reproduction and provides the material basis for population continuation. Nonetheless, the identity of the cells involved, the nature of transformation, and underlying regulators of oogenesis in crustaceans remain elusive. Here, an atlas of the ovary is plotted via single‐nuclei RNA sequencing (snRNA‐seq) in the mud crab Scylla paramamosain, resulting in five cell types, including germ cells, somatic cells, and three follicle cell types identified, which in turn provides abundant candidate markers for them. Moreover, profiles of ligand‐receptor in different cells of the crab ovary indicate the roles of cell communication in oogenesis. Dozens of transcription factors in the trajectory from oogonia to oocytes as well as the key molecules/pathways in somatic cells and follicle cells relevant to oogenesis are screened, which is evolutionarily conserved and its underlying regulatory mechanism is subject to some modification across various phyla. The spatiotemporal expression patterns of seven markers are further verified and the RNAi confirms the essential roles of piwi and VgR in oogenesis. These data help to elucidate the mechanism underlying gametogenesis and the evolution of reproductive strategy in invertebrates.
Discovery of Balasubramide Derivative with Tissue‐Specific Anti‐Inflammatory Activity Against Acute Lung Injury by Targeting VDAC1
Authors: Song Jin‐Qian , Shen Li‐Juan , Wang Hao‐Jie , Liu Qi‐Bing , Ye Lian‐Bao , Liu Kui , Shi Lei , Cai Bin , Lin Han‐Sen , Pang Tao 
Published: November 2024

AbstractMacrophage‐mediated inflammatory responses including pyroptosis are involved in the pathogenesis of sepsis and acute lung injury (ALI), for which there are currently no effective therapeutic treatments. The natural product (+)‐Balasubramide is an eight‐membered lactam compound extracted from the leaves of the Sri Lanka plant Clausena Indica and has shown anti‐inflammatory activities, but its poor pharmacokinetic properties limit its further application for ALI. In this study, a compound (+)3C‐20 is discovered with improved both pharmacokinetic properties and anti‐inflammatory activity from a series of (+)‐Balasubramide derivatives. The compound (+)3C‐20 exhibits a markedly enhanced inhibitory effect against LPS‐induced expressions of pro‐inflammatory factors in mouse macrophages and human PBMCs from ALI patients and shows a preferable lung tissue distribution in mice. (+)3C‐20 remarkably attenuates LPS‐induced ALI through lung tissue‐specific anti‐inflammatory actions. Mechanistically, a chemical proteomics study shows that (+)3C‐20 directly binds to mitochondrial VDAC1 and inhibits VDAC1 oligomerization to block mtDNA release, further preventing NLRP3 inflammasome activation. These findings identify (+)3C‐20 as a novel VDAC1 inhibitor with promising therapeutic potential for ALI associated with inflammation.
Precise HER2 Protein Degradation via Peptide‐Conjugated Photodynamic Therapy for Enhanced Breast Cancer Immunotherapy
Authors: Guo Changyong , Gao Fei , Wu Guoyuan , Li Jinqiu , Sheng Chunquan , He Shipeng , Hu Honggang 
Published: November 2024

AbstractBreast cancer, the most prevalent malignancy among women, frequently exhibits high HER2 expression, making HER2 a critical therapeutic target. Traditional treatments combining the anti‐HER2 antibody trastuzumab with immunotherapy face limitations due to toxicity and tumor microenvironment immunosuppression. This study introduces an innovative strategy combining HER2‐targeting peptides with the photosensitizer (PSs) pyropheophorbide‐a (Pha) via a gelatinase‐cleavable linker, forming self‐assembling nanoparticles. These nanoparticles actively target breast cancer cells and generate reactive oxygen species (ROS) under near‐infrared light, effectively degrading HER2 proteins. Upon internalization, the linker is cleaved, releasing Pha‐PLG and enhancing intracellular photodynamic therapy (PDT). The Pha‐PLG molecules self‐assemble into nanofibers, prolonging circulation, boosting immune induction, and activating CD8+ T cells, thus promoting a robust anti‐tumor immune response. In vivo, studies confirm superior biosafety, tumor targeting, and HER2 degradation, with increased cytotoxic T cell activity and improved antitumor immunity. This integrated strategy offers a promising new avenue for breast cancer treatment.