bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibrinolysis in left-sided mechanical prosthetic valve thrombosis with high INR
Authors: Nishanth KR , Shankar Mythri , Srinivasa KH , Manjunath CN , Ravindranath KS 
Published: April 2019

Background:
A significant number of patients with prosthetic valve thrombosis have a prothrombin time international normalised ratio in the therapeutic range at presentation. Surgery may not be possible in many patients and traditionally a high international normalised ratio is considered a relative contraindication for fibrinolysis.

Methods:
We conducted an observational study in patients with left-sided obstructive prosthetic valve thrombosis with international normalised ratio at or above the therapeutic range at presentation who received fibrinolysis. The fibrinolytic regimens, timing of initiation, success of fibrinolysis, risk of major and minor bleeding and ischaemic stroke were evaluated in the study.

Results:
Of 30 patients included in the study 70% received immediate fibrinolysis and in 30% it was delayed. The majority of patients (90%) presented with New York Heart Association class III/IV symptoms. The mean international normalised ratio at fibrinolysis was 3.04 ± 0.70 in the immediate group and 2.42 ± 0.89 in the delayed group. Haemodynamically stable patients who had delayed initiation of fibrinolysis had a trend towards less bleeding without an increase in mortality. The rates of intracranial haemorrhage (0% vs. 7.7%), minor bleeding (12.5% vs. 25.1%) and ischaemic stroke (0% vs. 30.7%) were lower in patients who received low dose infusion compared to a conventional dose.

Conclusions:
Fibrinolysis can be considered in patients with prosthetic valve thrombosis with high international normalised ratio at presentation. For haemodynamically stable patients, delayed initiation of fibrinolysis is associated with a marginally lower bleeding risk without an increase in mortality. Low dose infusion may be considered over a conventional dose as it is associated with a lower incidence of ischaemic stroke and a good rate of valve function restoration with a trend towards less bleeding.
The earlier, the better? Diagnostic experiences of parents in a community-based early intervention system for preschool children with autism
Authors: Iwasa Mitsuaki , Shimizu Yasuo , Hara Ikuko , Imai Miho , Honda Hideo 
Published: April 2019

Background and aims In many countries, early detection and diagnosis of autism spectrum disorder is largely dependent on parents’ initial concern with early symptoms of autism spectrum disorder. Previous research on parental perceptions of the autism spectrum disorder diagnostic process indicates that parental satisfaction may be due to either the timing of the diagnostic notification or the provision of post-diagnostic support. The objective of this research is to study the diagnostic notification process and its impact on parents who are informed of their young child’s diagnosis before they notice a problem and whose child undergoes early intervention therapy. Methods Eighty parents of preschool children diagnosed and undergoing early intervention for autism were surveyed to examine their experience of the diagnostic disclosure process. Results Of 68 respondents, 39 (58.2%) approved of the timing of diagnostic notification, while 10 of 13 dissatisfied respondents indicated that the diagnosis was communicated too late. However, there was no correlation between a higher degree of parental satisfaction with the diagnostic notification process and earlier timing of notification. Conclusions Although it is preferable to communicate a diagnosis of childhood autism as soon as possible, findings suggest that a highly individualized approach, allowing a degree of latitude in the timing of notification, may be permissible, depending on the individual case and parental readiness to receive the diagnosis. Implications Findings have clinical implications related to the concept of optimality of diagnostic disclosure as related to the diagnostic notification process, though later notification tends to lead to more dissatisfaction.
RETRACTED ARTICLE: Protective functions of myricetin in LPS-induced cardiomyocytes H9c2 cells injury by regulation of MALAT1
Authors: Sun Jinliang , Sun Jianhui , Zhou Xuezhong 
Published: April 2019

Abstract
Background
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a crucial mediator in response to inflammation. Myricetin protects cardiomyocytes against inflammatory injury. However, it’s still unexplored whether myricetin exerted anti-inflammatory properties via MALAT1. The purpose of our study was to validate the cardio-protective function of myricetin against myocarditis and its underlying mechanism in vitro.

Methods
H9c2 cells were pre-incubated with myricetin before stimulation with lipopolysaccharide (LPS). Enforced silence of MALAT1 was achieved by transducing short hairpin (sh)-MALAT1 into H9c2 cells. Next, cell viability and apoptotic cells were detected with cell counting kit-8 (CCK-8) and Annexin V-fluorescein isothiocyanate/propidium iodide (Annexin V-FITC/PI) apoptosis detection kit, respectively. Western blot assay was conducted to examine apoptosis-relative proteins, pro-inflammatory factors, and signaling regulators. Quantitative real-time PCR (qRT-PCR) was performed to quantify pro-inflammatory factors and MALAT1 at mRNA levels. Enzyme-linked immune sorbent assay (ELISA) was employed to determine protein concentration of pro-inflammatory factors.

Results
Myricetin ameliorated LPS-elicited reduction of cell viability, augment of apoptosis, and overexpression of monocyte chemo-attractant protein-1 (MCP-1) and interleukin-6 (IL-6) in H9c2 cells. Meanwhile, phosphorylation of p65 and inhibitor of nuclear factor kappa B alpha (IκBα) were suppressed. Besides, myricetin enhanced the expression of MALAT1 which was originally down-regulated by LPS. However, the protective effects of myricetin against LPS-caused inflammatory lesions were abrogated in MALAT1-deficiency cells, with the restored phosphorylation of p65 and IκBα.

Conclusion
Myricetin possessed an anti-inflammatory function against LPS-induced lesions in cardiomyocytes. Mechanically, myricetin up-regulated MALAT1, blocked LPS-evoked activation of nuclear factor-κB (NF-κB) inflammatory pathway, and, finally, exerted cardio-protective effects.
Alcohol Intake and Risk of Lethal Prostate Cancer in the Health Professionals Follow-Up Study
Authors: Downer Mary K. , Kenfield Stacey A. , Stampfer Meir J. , Wilson Kathryn M. , Dickerman Barbra A. , Giovannucci Edward L. , Rimm Eric B. , Wang Molin , Mucci Lorelei A. , Willett Walter C. , Chan June M. , Van Blarigan Erin L. 
Published: April 2019

PURPOSE It is unknown whether alcohol intake is associated with the risk of lethal (metastatic or fatal) prostate cancer. We examine (1) whether alcohol intake among men at risk of prostate cancer is associated with diagnosis of lethal prostate cancer and (2) whether intake among men with nonmetastatic prostate cancer is associated with metastasis or death. METHODS This prospective cohort study uses the Health Professionals Follow-Up Study (1986 to 2012). Our analysis of alcohol intake among men at risk of prostate cancer included 47,568 cancer-free men. Our analysis of alcohol intake among men with prostate cancer was restricted to 5,182 men diagnosed with nonmetastatic prostate cancer during follow-up. We examine the association of total alcohol, red and white wine, beer, and liquor with lethal prostate cancer and death. Multivariate Cox proportional hazards regression estimated hazard ratios (HRs) and 95% CIs. RESULTS Alcohol drinkers had a lower risk of lethal prostate cancer (any v none: HR, 0.84 [95% CI, 0.71 to 0.99]) without a dose-response relationship. Total alcohol intake among patients with prostate cancer was not associated with progression to lethal prostate cancer (any v none: HR, 0.99 [95% CI, 0.57 to 1.72]), whereas moderate red wine intake was associated with a lower risk (any v none: HR, 0.50 [95% CI, 0.29 to 0.86]; P trend = .05). Compared with none, 15 to 30 g/d of total alcohol after prostate cancer diagnosis was associated with a lower risk of death (HR, 0.71 [95% CI, 0.50 to 1.00]), as was red wine (any v none: HR, 0.74 [95% CI, 0.57 to 0.97]; P trend = .007). CONCLUSION Cancer-free men who consumed alcohol had a slightly lower risk of lethal prostate cancer compared with abstainers. Among men with prostate cancer, red wine was associated with a lower risk of progression to lethal disease. These observed associations merit additional study but provide assurance that moderate alcohol consumption is safe for patients with prostate cancer.
Dkk1 exacerbates doxorubicin-induced cardiotoxicity by inhibiting the Wnt/β-catenin signaling pathway
Authors: Liang Liying , Tu Yalin , Lu Jing , Wang Panxia , Guo Zhen , Wang Qianqian , Guo Kaiteng , Lan Rui , Li Hong , Liu Peiqing 
Published: April 2019

ABSTRACT
The cancer clinical therapy of doxorubicin (Dox) treatment is limited by its life-threatening cardiotoxic effects. Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes, but its effects on Dox-induced cardiomyopathy are poorly understood. Here, we found that the level of Dkk1 was significantly increased in Dox-treated groups, and this increase exacerbated Dox-induced cardiomyocyte apoptosis and mitochondrial dysfunction. Overexpressing Dkk1 aggravated Dox-induced cardiotoxicity in H9C2 cells. Similar results were detected when adding active Dkk1 protein extracellularly. Conversely, adding specific antibody blocking extracellular Dkk1 attenuated the cardiotoxic response to Dox. Adenovirus encoding Dkk1 was transduced through intramyocardial injection and exacerbated Dox-induced cardiomyocyte apoptosis, mitochondrial damage and heart injury in vivo. Furthermore, Wnt/β-catenin signaling was inhibited during Dox-induced cardiotoxicity, and the re-activation of β-catenin prevented the effect of overexpressed Dkk1 and Dox-induced cardiotoxicity. In conclusion, these results reveal the crucial role of the Dkk1–Wnt/β-catenin signaling axis in the process of Dox-induced cardiotoxicity and provide novel insights into the potential mechanism of cardiomyopathy caused by clinical application of Dox.
The plant stomatal lineage at a glance
Authors: Lee Laura R. , Bergmann Dominique C. 
Published: April 2019

ABSTRACT
Stomata are structures on the surfaces of most land plants that are required for gas exchange between plants and their environment. In Arabidopsis thaliana, stomata comprise two kidney bean-shaped epidermal guard cells that flank a central pore overlying a cavity in the mesophyll. These guard cells can adjust their shape to occlude or facilitate access to this pore, and in so doing regulate the release of water vapor and oxygen from the plant, in exchange for the intake of carbon dioxide from the atmosphere. Stomatal guard cells are the end product of a specialized lineage whose cell divisions and fate transitions ensure both the production and pattern of cells in aerial epidermal tissues. The stomatal lineage is dynamic and flexible, altering stomatal production in response to environmental change. As such, the stomatal lineage is an excellent system to study how flexible developmental transitions are regulated in plants. In this Cell Science at a Glance article and accompanying poster, we will summarize current knowledge of the divisions and fate decisions during stomatal development, discussing the role of transcriptional regulators, cell–cell signaling and polarity proteins. We will highlight recent work that links the core regulators to systemic or environmental information and provide an evolutionary perspective on stomata lineage regulators in plants.
Burden of drug-resistant pulmonary tuberculosis in Pakistani children: A cross-sectional study
Authors: Laghari Ghulam Shabbir , Hussain Zahid , Khemani Lavina , Hussain Syed Zohaib Maroof , Yaqoob Uzair 
Published: April 2019

Introduction: The incidence of drug-resistant tuberculosis (TB) is rapidly increasing worldwide. Children in high TB burden countries are rapidly being reported to be affected by Mycobacterium tuberculosis resistant to isoniazid and rifampicin. The aim of this study is to evaluate the pattern of drug sensitivity among children suffering with TB. Methods: Known cases of pulmonary TB, with sputum smear positive for acid-fast bacilli after two months of compliance to 1st line anti-tuberculous therapy were included after gaining informed consent. Specimens used for drug sensitivity testing were either sputum or bronchoalveolar lavage. Patient age, gender, history of TB contact, and duration of treatment were also recorded. Data was entered and analyzed using SPSS v.22. Results: Fifty children, 32 male (64%) and 18 female (36%) were included in the study. Their mean age was 12.84 ± 2.54 years. History of household TB contact was positive in 29 (58%) children. Among 1st line anti-tuberculous therapy, rifampicin resistance was highest at 33/50 (66%), and resistance to streptomycin and ethambutol were the lowest (6/50; 12%). There were 18 (36%) children with multidrug-resistant tuberculosis (MDR-TB). A positive history of household TB contact (either resistant or non-resistant) was seen to have a statistically significant impact on incidence of MDR-TB (p value=0.03) Conclusion: Pediatric drug-resistant TB is a rising concern. Awareness programs on national and international levels are needed to educate general population regarding the importance of preventing TB household contact, especially amongst children. With the selected method used to identify mainly older children with drug resistance, the yield for drug-resistant TB was found to be high.
A Branch-and-Bound Approach to the Traveling Salesman Problem with a Drone
Authors: Poikonen Stefan , Golden Bruce , Wasil Edward A. 
Published: April 2019

The Traveling Salesman Problem with a Drone (TSP-D) is a hybrid truck and drone model of delivery, in which the drone rides on the truck and launches from the truck to deliver packages. Our approach to the TSP-D uses branch and bound, whereby each node of the branch-and-bound tree corresponds with a potential order to deliver a subset of packages. An approximate lower bound at each node is given by solving a dynamic program. We provide additional variants of our heuristic approach and compare solution quality and computation times. Consideration is given to various input parameters and distance metrics. The online supplement is available at https://doi.org/10.1287/ijoc.2018.0826 .
Assessment of Fluorescent Dye Brilliant Sulfaflavine Deposition on Stainless Steel Screens as Spray Droplet Collectors
Authors: You Kyusuk , Zhu Heping , Abbott John Paul 
Published: April 2019

Abstract. The fluorescent dye Brilliant Sulfaflavine (BSF, CAS 2391-30-2) was investigated to determine its photo-stability and recovery on five spray deposition collectors: white plastic plate, nylon screen, and stainless steel (SS) screens of three mesh sizes (40, 60, and 80). The photo-stability of the deposited dye was determined by measuring the variance in fluorescence intensity after daylight exposure. The recovery rates were investigated with statically dispensed droplets and dynamically discharged droplets. In addition, droplet penetration through the screen collectors and the amount of unrecovered dye on reprocessed collectors were assessed to better understand the differences in dye recovery rates among different collector types. Photo-degradation tests verified that all collector types were insignificant in fluorescence degradation (&lt;3.1%) after 120 min of solar exposure. Nylon screens had the lowest dye recovery rate (87.0%) for statically dispensed droplets, whereas plastic plates and SS screens recovered more than 90% of deposited dye. For dynamically discharged droplets, the 60-mesh and 80-mesh SS screens recovered more than 70% of the deposited dye, whereas nylon screens showed less than 50% recovery rate. These results were substantiated visually with a high-speed imaging system that detected droplets penetrating more frequently through screens with larger mesh openings. Throughout ten continuous reprocessing cycles of the fluorimetry test, the fluorescence intensity on reprocessed nylon and 80-mesh SS screen collectors increased by 16.8% and 12.7%, respectively, while there was less than 1% change in fluorescence intensity on the 40-mesh and 60-mesh SS screens. These results were clarified through dye residue verification using digital image analysis. Keywords: Fluorescence intensity, Photo-degradation, Recovery rate, Spray deposition assessment, Stainless steel screen.
Repeat Emergency Department Visits for Individuals With Intellectual and Developmental Disabilities and Psychiatric Disorders
Authors: Durbin Anna , Balogh Robert , Lin Elizabeth , Wilton Andrew S. , Selick Avra , Dobranowski Kristin M. , Lunsky Yona 
Published: April 2019

Abstract
Although individuals with intellectual and developmental disabilities (IDD) and psychiatric concerns are more likely than others to visit hospital emergency departments (EDs), the frequency of their returns to the ED within a short time is unknown. In this population-based study we examined the likelihood of this group returning to the ED within 30 days of discharge and described these visits for individuals with IDD + psychiatric disorders (n = 3,275), and persons with IDD only (n = 1,944) compared to persons with psychiatric disorders only (n = 41,532). Individuals with IDD + psychiatric disorders, and individuals with IDD alone were more likely to make 30-day repeat ED visits. Improving hospital care and postdischarge community linkages may reduce 30-day returns to the ED among adults with IDD.
Reliability of Informant-Report Measures of Executive Functioning in Children With Down Syndrome
Authors: Esbensen Anna J. , Hoffman Emily K. , Shaffer Rebecca , Chen Elizabeth , Patel Lina , Jacola Lisa 
Published: April 2019

Abstract
The current study evaluates the psychometric properties of the Behavior Rating Inventory of Executive Function (BRIEF) with children with Down syndrome. Caregivers of 84 children with Down syndrome rated their child's behavior with the BRIEF. Teacher ratings were obtained for 57 children. About 40% of children with Down syndrome were reported by parents, and 70% by teachers, to exhibit clinically significant challenges with executive functioning. Distribution of scores was normal, internal consistency for subscales was questionable to primarily excellent, and inter-rater reliability was poor to good. Normative data conversions controlled for age, IQ, and gender differences, with some exceptions. The study findings suggest that the BRIEF and its subscales generally performed in a psychometrically sound manner among children with Down syndrome.
Validating and Applying the CSBS-ITC in Neurogenetic Syndromes
Authors: Hamrick Lisa R. , Tonnsen Bridgette L. 
Published: April 2019

AbstractAlthough social communication skills are commonly delayed in children with neurogenetic syndromes (NGS), skill profiles in very young children are largely under characterized, in part due to the lack of validated assessment measures appropriate for these populations. We addressed this gap by validating and applying a popular early social communication screening measure, the Communication and Symbolic Behavior Scales Developmental Profile – Infant-Toddler Checklist (CSBS-ITC) in three previously understudied neurogenetic groups: Angelman, Prader-Willi, and Williams syndromes. Our results suggest that when used within the appropriate scope of screening and surveillance, the CSBS-ITC detects meaningful variability in skills across ages in young children with NGS and may provide useful information about both individual- and population-level social communication profiles in these populations.
Balanced Scorecard as a Performance Measurement System in Malaysian Private Institutions of Higher Learning: Empirical Findings
Authors: Hafiz bin Rosli Mohamad , Fawzia binti Md Ariff Farrah , Binti Said Jamaliah 
Published: April 2019

Balanced Scorecard (BSC) is a well-known performance measurement tools and some researchers have highlighted its relevance to Institutions of Higher Learning (IHL). In order to response to the globalization phenomenon today, IHL must adopt the most suitable tool such as Performance Measurement System (PMS) in assessing academicians’ performance. The adoption of Strategic Performance Measurement System (SPMS), proven to realize significant cost saving, improve personal satisfactions and enhance organizational performances based on previous studies. Therefore, the objective of this paper is to determine the relationship between leadership, communication and academic qualification towards the adoption of BSC. Data were collected quantitatively through a survey questionnaire with the usable response rate of 78.57%. The descriptive results of this study revealed that the majority of academicians’ extensively agrees that the measurement used in the BSC are effective in assessing academicians’ performances. This finding also reveals that leadership, communication and academic qualification were significantly influenced the adoption of BSC. The findings from this study have advanced the literature on BSC especially in the education sector. It also provides a better understanding of BSC as the performance measurement tool in assessing academicians’ performance.
Domination Number of Rough Ideal based Rough Edge Cayley Graph
Authors: Praba B. , A. B. Obilia X. 
Published: April 2019

In this paper, we define a Cayley graph corresponding to the Rough ideal J of the Rough semiring (T, âˆ†, âˆ‡). The Domination number of the Rough Ideal based Rough Edge Cayley graphs Â and )) where Â contains the non-trivial elements of J are derived and illustrated through examples. Interpretation of a communication network is done in the form of Rough Ideal based Rough Edge Cayley Graph.Â Â
Congestion Management in a Restructured Power System Using Solar Photovoltaics
Authors: V Subramaniyan , V Gomathi 
Published: April 2019

The modern power grid is one of the most complex engineering machines in existence. There is a continuous transformation in the grid conditions that necessitate variations in the electricity production. Energy is a remarkable donor in environmental change, representing around 60 percent of the aggregate worldwide greenhouse gas outflow. Lessening the carbon force of energy, the share of non-conventional energy sources in the worldwide vitality blend is relied upon to expand supportability. So renewable energy is one of the most capable results for taking care of expanding energy demand. This paper proposed a method to lessen the congestion in the deregulated environment. The congestion in the transmission lines is identified by optimal power flow (Newton Raphson) method.Â Congestion in the transmission lines is lessened by connecting a dispersed generating unit called as Solar Photovoltaic at PQ (load) bus.Â A way to decide the ideal position of a Dispersed Generating unit has been suggested based on the Line Relief Sensitivity (LRS) based attitude.Â The effectiveness of methodology has been validated using standard IEEE 30 bus system.Â Â Â