bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using a ‘Students as Partners’ model to develop an authentic assessment promoting employability skills in undergraduate life science education
Authors: Van Kelsey , Tasawar Sana , Brendel Elaina B. K. , Law Camille , Mahajan Anisha , Brownell‐Riddell Carissa , Diamond Natalia , Ritchie Kerry , Monk Jennifer M. 
Published: December 2024

Authentic assessments (AA) include three principles, realism, cognitive challenge, and evaluative judgment, and replicate professional workplace expectations. Developing AA in undergraduate life science education is necessary to promote critical skill development and adequately prepare students for the workplace. Using a ‘Students‐as‐Partners’ (SAP) approach, five students, an educational developer and the instructor codeveloped an AA requiring students to utilize scientific literacy (SL) and critical thinking (CT) skills to develop a data extraction table and generate communication outputs for scientific and nonscientific audiences. Subsequently, the SAP‐developed AA was completed by students (n = 173) enrolled in a fourth‐year life sciences and pathophysiology course who completed an online survey providing feedback about their perceived development of critical skills and the relevance of the assignment to the workplace. The top transferable skills students reported the greatest growth in were SL (41.6%, n = 72), communication (34.7%, n = 60), CT (16.2%, n = 28), and problem‐solving (7.5%, n = 13). Student self‐assessed and instructor‐assessed grades were positively correlated, wherein 60.6% of students assessed their AA grades below the instructor's assessment and 4.7% of students assigned themselves the same grade as the instructor. Students' perceived stress levels were (a) negatively correlated with assignment grades and feelings of enjoyment, hope and pride, and (b) positively correlated with feelings of anger, anxiety, shame, and hopelessness while working on the assignment. This study demonstrates the impact of AA on the student learning experience and the relevance of AA to help prepare students for life science careers.
Perceptual Expertise of Forensic Examiners and Reviewers on Tests of Cross‐Race and Disguised Face Identification and Face Memory
Authors: Yates Amy N. , Cavazos Jacqueline G. , Jeckeln Géraldine , Hu Ying , Noyes Eilidh , Hahn Carina A. , O'Toole Alice J. , Phillips P. Jonathon 
Published: December 2024

ABSTRACTForensic facial professionals have been shown in previous studies to identify people from frontal face images more accurately than untrained participants when given 30 s per face pair. We tested whether this superiority holds in more challenging conditions. Two groups of forensic facial professionals (examiners, reviewers) and untrained participants were tested in three lab‐based tasks: other‐race face identification, disguised face identification, and face memory. For other‐race face identification, on same‐race faces, examiners were superior to controls; on different‐race identification, examiners and controls performed comparably. Examiners were superior to controls for impersonation disguise, but not consistently superior for evasion disguise. Examiners' performance on the Cambridge Face Memory Test (CFMT+) was marginally better than reviewers and controls. We conclude that under laboratory‐style conditions, professional examiners' identification superiority does not generalize completely to other‐race and disguised faces. Future work should administer other‐race and disguise face identification tests that allow forensic professionals to follow methods and procedures they typically use in casework.
Multifunctional Cement‐Based Composite with Advanced Self‐Sensing, Electrothermal, and Electrochemical Properties
Authors: Jin Peng , Kohestanian Mohammad , Hasany Masoud , Akhiani Amir Reza , Su Yilin , Mehrali Mehdi 
Published: December 2024

AbstractDeveloping multifunctional construction materials with advanced functionalities and excellent mechanical toughness remains a significant challenge within the field of civil engineering. Herein, a scalable and cost‐effective approach for fabricating versatile cement‐based composites is introduced. This is achieved by pre‐embedding a 3D‐printed conductive lattice framework (LF) into cement pastes with the incorporation of carbon black (CB). LFs contribute significantly to the flexural extension of the composite structure and when combined with CB, they substantially improve the conductivity of the matrix, enabling its self‐sensing applications. Moreover, the obtained conductivity enables the application of electrochemical deposition techniques for in situ polymerization and deposition of polypyrrole (PPy) onto the composite surface. PPy coatings further endow the cement‐based composites with excellent electrothermal and electrochemical performance. For instance, applying a direct current voltage of 18 V for 10 min results in a temperature increase exceeding 45 °C, indicating promising de‐icing capabilities. When assembled as a supercapacitor, it exhibits an outstanding energy density, reaching 61.7 µWh cm−2 at a power density of 150 µW cm−2 and demonstrating its potential for energy storage application in the construction sector. In conclusion, this study introduces an innovative strategy for the advancement of intelligent and multifunctional cement‐based construction materials, emphasizing the importance of multifunctionality in modern construction practices.
Engineering of Nanofibers Embedded with Targeted Nanoparticles Breaks Redox Levers for Glioblastoma Therapy
Authors: Ma Yuan , Li Mengqi , Fu Xiao , Li Dongchen , Gao Chen , Li Zhiwei , Zhang Yulin , Gao Zhiliang , Geng Huimin , Li Gang , Ni Shilei , Cui Jiwei 
Published: December 2024

AbstractGlioblastoma multiforme (GBM), one of the most aggressive brain cancers, presents substantial therapeutic challenges, particularly concerning postsurgical recurrence and inherent drug resistance. In this study, a nanofiber‐based drug delivery system integrating platinum pro‐drugs and hemoglobin into mesoporous silica nanoparticles (HB/HSPt@MS NPs) is reported, which are surface‐modified with poly(ethylene glycol) (PEG) and targeting molecules, and subsequently embedded into nanofibers using an electrostatic spinning approach. Applied to the tumor site, these nanofibers leverage folate receptor overexpression on the tumor and the tumor's redox state to enable precise platinum release, inducing cell death through a targeted drug resistance pathway. The incorporation of hemoglobin is crucial as it disrupts the redox balance within GBM cells by facilitating the influx of iron ions, leading to lipid peroxidation through the Fenton reaction. This induces oxidative stress and overwhelms the cellular antioxidant mechanisms. This dual mechanism of action—direct cytotoxicity through sustained drug release and indirect cytotoxicity through induced oxidative stress—enhances the therapeutic efficacy of platinum drugs. The system effectively bypasses the blood‐brain barrier and reduces systemic toxicity, significantly improving delivery efficacy. Both in vitro and in vivo evaluations demonstrate substantial inhibition of tumor growth and recurrence, highlighting the potential for personalized GBM therapy.
Polyurethane‐Based Bioglue for the Repair of Arterial Ruptures
Authors: Wu Wenxuan , Xuan Chengkai , Jiang Yaqiang , Lu Haotian , Yan Shengtao , Shi Xuetao 
Published: December 2024

AbstractA bioglue with fast blood absorption and strong adhesion, capable of stopping bleeding through physical blockage rather than coagulation, is imperative for treating arterial hematorrhea during surgery and in wilderness first aid. Here, we developed a two‐component polyurethane‐based arterial glue (PAG). The key strategy of this work is to optimize the hydrophilicity and crosslinking density of the bioglue by modulating the proportion of hydrophilic polyethylene glycol (PEG)‐based urethane prepolymer, the hydrophobicamine crosslinkers, and the functionality of the crosslinkers. Compared with commercial PEG‐based bioglue, PAG has a similar water absorption rate but less swelling. Furthermore, owing to the hydrogen bonding originating from the urethane/urea bonds and extracovalent bond formation with tissue, PAG showed ≈2 times greater adhesive strength than commercial PEG‐based bioglues. In addition, PAG has good hemocompatibility and maintains cured integrity even under circulating blood flushing conditions, thereby reducing the risk of arterial embolism. This bioglue demonstrated a more reliable sealing effect with a higher survival rate compared to commercial fibrin and PEG‐based bioglues on the rat abdominal aorta and rabbit carotid artery in open operations; moreover, it can be assembled into a commercial balloon dilation catheter system, enabling minimally invasive surgeries on the porcine femoral artery.
Copper(I)‐Mediated Site‐Selective Tertiary δ–κ‐C(sp3)−H Bond Chlorination of Ketones and Carboxylic Esters and Amides by Dichloramine‐T
Authors: Diaz Jordan , Zhang Yongsheng , Merrett James Theodore , Or Wai Tsun , Chan Philip Wai Hong 
Published: December 2024

AbstractA synthetic method to prepare δ–κ‐chloroketones, ‐esters and ‐amides that relies on the copper(I)‐mediated chlorination at the unactivated tertiary δ–κ‐C(sp3)−H bond of ketones, carboxylic esters, and amides by dichloramine‐T is presented. By exploiting the ability of the N‐chloramide to act as both the hydrogen atom transfer (HAT) and chlorination reagent, the reactions were shown to be site‐selective with halogenation only occurring at the unactivated tertiary carbon center situated four to ten C−C bond distances away from the carbonyl functional group in the substrate. The site‐selectivity of the chlorination protocol was further exemplified by the installing of the C−Cl bond at the distal position of one example containing two tertiary carbon centers and the late‐stage functionalization of two drug molecules.
Manganese Promoted Reductive Cross‐Coupling of Phosphine Chlorides with Disulfides for the Synthesis of Thiophosphanes
Authors: Zhang Chao‐Peng , Wang Tian‐Zhang , Yang Zhong‐Jiang , Liang Yu‐Feng 
Published: December 2024

AbstractHerein we reported a manganese promoted reductive cross‐coupling approach to construct P−S bond. This is a practical method for the synthesis of mono‐thiophosphanes, bis‐thiophosphanes and tri‐thiophosphanes under mild conditions. The strategy featured a wide range of substrate scope including various disulfides and phosphine chlorides, constructing diverse sulfur‐containing organophosphorus compounds from inodorous and readily available starting materials. The employment of reductive conditions avoided the generation of phosphorothioates (PV) by‐products. Ultimately, gram‐scale synthesis and applications were explored. Extensive experiments indicated that the phosphine radical cascade process was involved in the catalytic cycle.
Application‐Targeted Metal Grid‐Enhanced Transparent Electrodes for Organic Photovoltaics
Authors: Burridge Nicholas , Burwell Gregory , Sandberg Oskar J. , Armin Ardalan , Meredith Paul 
Published: December 2024

AbstractTransparent conducting electrodes (TCEs) are integral components in optoelectronic devices, facilitating both light transmission and electrical conduction. Over the past four decades, substantial advancements have been made in TCE materials, including transparent conducting oxides (TCOs) such as indium tin oxide (ITO) and fluorine‐doped tin oxide (FTO), which remain dominant technologies in practical applications. Despite these advancements, current TCEs exhibit relatively high sheet resistance (Rsheet), posing a significant barrier to the scale‐up of solution‐processed devices such as organic photovoltaics (OPVs). This work addresses the scaling limitations of TCEs in OPVs by proposing the integration of a TCE with a metallic grid (g‐TCE) to mitigate the high Rsheet issue. The performance of g‐TCEs in OPVs is evaluated across various irradiance levels and TCE Rsheet values. Additionally, a novel, unitless figure‐of‐merit tailored to specific PV devices is introduced, which enables benchmarking beyond traditional TCE FoMs. Exemplifications of g‐TCEs include aluminium‐doped zinc oxide (AZO), which has an equivalent Rsheet of 0.5 Ω □−1, while maintaining an average visible transmittance exceeding 77%, outperforming all state‐of‐the‐art monolithic TCE materials. These findings demonstrate that g‐TCEs present a viable pathway for the development of large‐area, solution‐processed PV devices.
Resilience of Small Beef Packers and the USDA Meat Supply Chain Initiative
Authors: Dhoubhadel Sunil P. , Azzam Azzeddine , Khanal Binod 
Published: December 2024

ABSTRACTWe focus on the plant‐size resilience relationship among small beef packers during COVID‐19. Defining resilience as the ability to maintain or increase slaughter and non‐resilience as otherwise, we use survey and secondary data to estimate a logit model where resilience is a function of a plant's capacity and age in addition to labor condition variables, COVID‐19 policy, and beef production status of the state in which the plant is located. We find resilience is inversely related to plant size but is highest in states with a mask mandate. Implications for the efficacy of the USDA capacity expansion program are highlighted.
Subacute Neuropathy Post‐Liver Transplantation in Zellweger Spectrum Disorder: A Case Report
Authors: Gonzalez Clarissa , Cohen Madelyn J. , Hong Juhee , Calame Daniel , Marri Kavitha , Harpavat Sanjiv , Wangler Michael F. , Mysore Krupa 
Published: December 2024

ABSTRACTPeroxisome biogenesis disorders‐Zellweger spectrum disorder (PBD‐ZSD) is a rare genetic disease caused by mutations in the genes involved in peroxisome biogenesis. PBD‐ZSD presentations vary in severity, and treatment of PBD‐ZSD remains supportive focused on specific complications. A few reported cases of the use of liver transplantation to treat either neurological symptoms or liver dysfunction and cirrhosis in PBD‐ZSD have been published. In this case report, we document the course of a 16‐year‐old boy diagnosed with PBD‐ZSD and a delayed and unexpected neuropathy that developed after undergoing orthotopic liver transplantation (OLT) for which the indication was liver cirrhosis. Following OLT, the patient's gamma‐glutamyl transferase (GGT), aspartate aminotransferase (AST), alanine transaminase (ALT), and albumin normalized; however, he developed a polyneuropathy, the cause of which was investigated with conditions such as inflammatory neuropathies (Guillain Barré syndrome: GBS/chronic inflammatory demyelinating polyneuropathy: CIDP), drug effect, or underlying complication of PBD‐ZSD all considered possible. His neuropathic symptoms improved and therefore this case represents an exploration of an apparent delayed and resolving subacute neuropathy in PBD‐ZSD after OLT.
Functional Roles of Five Cytochrome P450 Transcripts in the Susceptibility of the Yellow Fever Mosquito to Pyrethroids Revealed by RNAi Coupled With Insecticide Bioassay
Authors: Soumalia Issa Moustapha , Johnson Rachel , Park Yoonseong , Zhu Kun Yan 
Published: December 2024

ABSTRACTWe evaluated the possible roles of five cytochrome P450 transcripts in the susceptibility of both adults and larvae of Aedes aegypti to three pyrethroids using RNA interference (RNAi) coupled with insecticide bioassays. RNAi by feeding larvae with chitosan/dsRNA nanoparticles led to reductions of CYP6AA5, CYP6AL1, CYP9J32, CYP4J16A, and CYP4J16B transcripts by 38.7%, 46.0%, 46.52%, 44.0%, and 41.0%, respectively, and increased larval mortality by 46.0% to permethrin when CYP9J32 was silenced and by 41.2% to cypermethrin when CYP6AA5 was silenced. RNAi by injecting dsRNA in adults led to reductions of CYP6AA5, CYP6AL1, and CY4J16A transcripts by 77.9%, 80.0%, and 87.1% (p < 0.05), respectively, at 96 h and reduction of CYP9J32 transcript by 46.5% at 24 h after injection. In contrast, CYP4J16B was repressed by 78.2% at 72 h after injection. Exposure of the adults injected with CYP6AA5 dsRNA resulted in 1.5‐ to 2.0‐fold increased susceptibility to cypermethrin as compared with the control. Homology modeling of CYP6AA5 followed by ligand docking showed that distances between the heme iron and the putative aromatic hydroxylation site were 9.2, 7.2, and 9.1 Å for permethrin, cypermethrin, and deltamethrin, respectively. For the aliphatic hydroxylation site, these distances were 5.3, 4.9, and 3.1 Å. These results supported that CYP6AA5 may be able to metabolize cypermethrin preferentially by aliphatic hydroxylation as indicated by the close interaction with the heme iron. Our study also suggests that the detoxification roles of cytochrome P450 genes in A. aegypti may vary according to the mosquito developmental stages, cytochrome P450 genes, and insecticides.
False Confessions: An Integrative Review of the Phenomenon
Authors: Welner Michael , DeLisi Matt , Janusewski Theresa 
Published: December 2024

ABSTRACTConfessions are an important evidentiary part of the legal process, and false confessions have been notable contributors to wrongful convictions. However, academic research in the psychology and law field primarily relies on student or volunteer samples in staged exercises, methodological features that lack ecological validity for replicating police interrogation or the pressures distinctive to high stakes crime investigations. Here, we provide an integrative review of research and data on false confessions during police interrogations with distinctions of key concepts, relevant case law pertaining to confessions including several U.S. Supreme Court decisions, updating the typology of false confessions, the quantification of false confessions, risk factors for false confessions, interrogation risk factors for false confessions, validity threats to false confessions research, and recommended directions for informing courts and the law.
Psychotherapists' interoceptive awareness and accuracy
Authors: Halonen Satu , Laitila Aarno , Parviainen Tiina , Kykyri Virpi‐Liisa 
Published: December 2024

AbstractObjectiveThis study examined the different dimensions of interoception in psychotherapists to better understand the significance of interoception in therapeutic work.MethodsData on objectively defined interoceptive accuracy, response confidence and subjectively assessed interoceptive awareness were collected from psychotherapists. Forty Finnish psychotherapists varying in work experience and theoretical orientation participated in this field study. The interoceptive awareness of their clients (n = 67) in individual psychotherapy was also assessed. The psychotherapists' interoceptive accuracy was compared with that of a reference sample of working adults (n = 38). Data were analysed using mixed methods. The research approach was descriptive and pragmatic.ResultsThe results showed statistically significantly higher interoceptive awareness in the psychotherapists than clients, which showed a large effect size: Cohen's d = 1.54, 95% CI [1.10, 1.99]. However, the therapists' interoceptive accuracy did not differ from that of a reference sample of persons without therapy training, d = 0.06, CI [−0.40, 0.53].ConclusionExpanding knowledge on interoception can help psychotherapists to develop professionally while supporting their psychological well‐being. This study contributes to research on the role of interoceptive accuracy and awareness in embodied interaction in psychotherapy.
Cytokine expression and cytokine‐mediated cell–cell communication during skeletal muscle regeneration revealed by integrative analysis of single‐cell RNA sequencing data
Authors: Barai Pallob , Chen Jie 
Published: December 2024

AbstractSkeletal muscles undergo self‐repair upon injury, owing to the resident muscle stem cells and their extensive communication with the microenvironment of injured muscles. Cytokines play a critical role in orchestrating intercell communication to ensure successful regeneration. Immune cells as well as other types of cells in the injury site, including muscle stem cells, are known to secret cytokines. However, the extent to which various cell types express distinct cytokines and how the secreted cytokines are involved in intercell communication during regeneration are largely unknown. Here we integrated 15 publicly available single‐cell RNA‐sequencing (scRNA‐seq) datasets of mouse skeletal muscles at early regeneration timepoints (0, 2, 5, and 7 days after injury). The resulting dataset was analyzed for the expression of 393 annotated mouse cytokines. We found widespread and dynamic cytokine expression by all cell types in the regenerating muscle. Interrogating the integrated dataset using CellChat revealed extensive, bidirectional cell–cell communications during regeneration. Our findings provide a comprehensive view of cytokine signaling in the regenerating muscle, which can guide future studies of ligand‐receptor signaling and cell–cell interaction to achieve new mechanistic insights into the regulation of muscle regeneration.
Linear and Two‐Dimensional Infrared Spectroscopy of the Multifunctional Vibrational Probe, 3‐(4‐Azidophenyl) Propiolonitrile. Deperturbing a Fermi Triad by Isotopic Substitution
Authors: Gräve Claudia , Lindner Jörg , Flesch Stefan , Domenianni Luis I. , Vöhringer Peter 
Published: December 2024

AbstractInfrared probes are chemical moieties whose vibrational modes are used to obtain spectroscopic information about structural dynamics of complex systems; in particular, of biomacromolecules. Here, we explore the vibrational spectroscopy and dynamics of a reagent, 3‐(4‐azidophenyl)propiolonitrile (AzPPN), for selectively tagging thiols in protein environments with a multifunctional infrared probe containing both, an azide and a nitrile chromophore. The linear infrared spectrum of AzPPN is heavily perturbed in the antisymmetric azide stretching region as a result of accidental Fermi resonances. Isotopically labeling the azide group at the β‐position deperturbs the spectrum considerably and reveals two combination tones that mix with the antisymmetric stretching fundamental into a Fermi triad of hybrid vibrational excitations. Moreover, two‐dimensional infrared (2DIR) spectra were recorded for 15Nβ‐labeled AzPPN, which reveal waiting‐time‐dependent spectral shifts of diagonal peaks and dynamic buildups of cross peaks. The 2DIR‐spectral evolution is indicative of intramolecular distribution of the pump‐induced excess vibrational energy into low‐frequency modes of the molecule that are coupled to either the azide or the nitrile stretching transition dipoles. Finally, IR‐pump/IR‐probe spectra with selective narrowband excitation reveal a time constant of 2.3 ps for intramolecular vibrational redistribution (IVR) and 18 ps for the final energy dissipation into the solvent. The cross‐peak dynamics corroborate a notion in which IVR within the AzPPN‐molecule is an irreversible process.
Distinct Mechanisms of Triplet Pair Decay in Amorphous and Crystalline Heteroacene Thin Films
Authors: Rugg Brandon K. , De Angana , Santhakumar Sarath , Ma Qiushi , Fluegel Brian , Thorley Karl J. , Anthony John E. , Huang Libai , Johnson Justin C. 
Published: December 2024

AbstractTriplet pairs (TT) in crystalline molecular semiconductors have unique spin properties of interest for quantum information or enhancing solar photoconversion. The population and diffusion dynamics of TT have been the subject of recent studies, both in covalent dimers and in crystalline systems. Here, we monitor the triplet population in neat polycrystalline and amorphous films of a heteroacene with known TT spectral properties and tunable spin polarization depending on the intermolecular geometry. Transient measurements reveal an anomalous power dependence in polycrystalline films that we attribute to the fast diffusion and interaction of dissociated triplet pairs confined to one‐dimensional stacks of strongly coupled molecules. The nongeminate triplet interaction after dephasing facilitates conversion to the triplet 3TT and eventually T1+S0. Amorphous films have no power dependence and proceed directly from 1TT to 3TT and subsequently T1+S0 via state mixing facilitated by nonparallel geometries and weak exchange coupling.