bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aumento de casos de infección por VIH en Chile
Authors: Pérez Carlos 
Published: October 2019

El primer paciente con Infección por VIH en Chile fue atendido en el Hospital Clínico UC en 1984. Desde esa época, más de 72000 personas han sido diagnosticadas y cerca de 10000 han fallecido a consecuencia de esta enfermedad. De acuerdo al reporte 2019 de ONUSIDA, a diciembre del 2018 vivían en Chile 71000 personas portadoras del virus, de las cuales 61000 estarían ya diagnosticadas. Según el mismo informe, en el 2018 se reportaron 5000 nuevas infecciones, cifra que ha ido en aumento desde el 2010, año en que se confirmaron 3700 casos. Por otra parte, de acuerdo a información entregada por el Instituto de Salud Pública (ISP) de Chile, el 2018 se confirmaron 6948 nuevas infecciones, mientras que en el año 2010 se diagnosticaron 3218 pacientes. Esta diferencia entre los datos nacionales y de ONUSIDA se debería a que este último organismo efectúa una estimación basada en los casos reportados oficialmente por el Ministerio de Salud (MINSAL) y la predicción que efectúa el software Spectrum y no considera necesariamente todas las confirmaciones de laboratorio que efectúa el ISP. En cualquiera de los dos escenarios, no cabe duda que el número de nuevos diagnósticos en Chile ha crecido de manera exponencial en los últimos años, en contraste con el descenso que se observa en la mayoría de los países. Ello nos sitúa entre las diez naciones con mayor aumento en la infección por VIH/SIDA a nivel global.
Targeting Extracellular Heat Shock Protein 70 Ameliorates Doxorubicin‐Induced Heart Failure Through Resolution of Toll‐Like Receptor 2–Mediated Myocardial Inflammation
Authors: Liu Peng , Bao Hua‐Yan , Jin Cai‐Cai , Zhou Ji‐Chao , Hua Fang , Li Ke , Lv Xiao‐Xi , Cui Bing , Hu Zhuo‐Wei , Zhang Xiao‐Wei 
Published: October 2019

Background
Heart failure (HF) is one of the most significant causes of morbidity and mortality for the cardiovascular risk population. We found previously that extracellular HSP70 (heat shock protein) is an important trigger in cardiac hypertrophy and fibrosis, which are associated with the development of heart dysfunction. However, the potential role of HSP70 in response to HF and whether it could be a target for the therapy of HF remain unknown.

Methods and Results
An HF mouse model was generated by a single IP injection of doxorubicin at a dose of 15 mg/kg. Ten days later, these mice were treated with an HSP70 neutralizing antibody for 5 times. We observed that doxorubicin treatment increased circulating HSP70 and expression of HSP70 in myocardium and promoted its extracellular release in the heart. Blocking extracellular HSP70 activity by its antibody significantly ameliorated doxorubicin‐induced left ventricular dilation and dysfunction, which was accompanied by a significant inhibition of cardiac fibrosis. The cardioprotective effect of the anti‐HSP70 antibody was largely attributed to its ability to promote the resolution of myocardial inflammation, as evidenced by its suppression of the toll‐like receptor 2–associated signaling cascade and modulation of the intracellular distribution of the p50 and p65 subunits of nuclear factor‐κB.

Conclusions
Extracellular HSP70 serves as a noninfectious inflammatory factor in the development of HF, and blocking extracellular HSP70 activity may provide potential therapeutic benefits for the treatment of HF.
The Allographic Use of Hebrew and Arabic in the Samaritan Manuscript Culture
Authors: Schorch Stefan 
Published: October 2019

Abstract
In the 10th/11th century, Arabic became both the vernacular and literary language of the Samaritan community, along with the two languages of the liturgy: Samaritan Hebrew and Samaritan Aramaic; Samaritan Neo Hebrew was also employed at this time mainly for the composition of religious poems. Together with the introduction of the Arabic language, the Samaritans started to use the Arabic script, along with the Samaritan Hebrew formal and cursive scripts. In comparison with the use of the Arabic script, the Samaritan Hebrew script served mostly for more sacred texts or was employed in order to mark certain textual passages with a higher degree of sacredness. Allography of Arabic in Samaritan Hebrew letters is attested in Samaritan manuscripts since the beginning of the 13th century, although it was introduced most probably at an earlier date. This allography is employed mainly for the Arabic translation of the Samaritan Torah, for the Arabic translations of prayers, and for Samaritan Hebrew or Samaritan Aramaic quotes in Arabic texts. The replacement of Arabic by Modern Israeli Hebrew as the primary vernacular among the Samaritans living in the State of Israel led to a revival of Samaritan Hebrew allography for Arabic texts in the 20th century, mainly in festival poems in Arabic language, which are performed at certain occasions, although not all congregants are still familiar with the Arabic language and script. A close analysis demonstrates that Samaritan Hebrew allography of Arabic is the result of an intense contact between two scribal cultures, both of which were well established amongst the Samaritans. The allographic use of the Samaritan Hebrew script for writing Arabic texts originally did not aim to make these texts more accessible to Samaritan readers, but rather was employed to mark Arabic texts as belonging to the realm of the sacred.
Eddy Activity Response to Global Warming–Like Temperature Changes
Authors: Yuval Janni , Kaspi Yohai 
Published: October 2019

AbstractGlobal warming projections show an anomalous temperature increase both at the Arctic surface and at lower latitudes in the upper troposphere. The Arctic amplification decreases the meridional temperature gradient, and simultaneously decreases static stability. These changes in the meridional temperature gradient and in the static stability have opposing effects on baroclinicity. The temperature increase at the upper tropospheric lower latitudes tends to increase the meridional temperature gradient and simultaneously increase static stability, which have opposing effects on baroclinicity as well. In this study, a dry idealized general circulation model with a modified Newtonian cooling scheme, which allows any chosen zonally symmetric temperature distribution to be simulated, is used to study the effect of Arctic amplification and lower-latitude upper-level warming on eddy activity. Due to the interplay between the static stability and meridional temperature gradient on atmospheric baroclinicity changes, and their opposing effect on atmospheric baroclinicity, it is found that both the Arctic amplification and lower-latitude upper-level warming could potentially lead to both decreases and increases in eddy activity, depending on the exact prescribed temperature modifications. Therefore, to understand the effect of global warming–like temperature trends on eddy activity, the zonally symmetric global warming temperature projections from state-of-the-art models are simulated. It is found that the eddy kinetic energy changes are dominated by the lower-latitude upper-level warming, which tends to weaken the eddy kinetic energy due to increased static stability. On the other hand, the eddy heat flux changes are dominated by the Arctic amplification, which tends to weaken the eddy heat flux at the lower levels.
Hybridisation of human resources management practices: the case of local government in France
Authors: Desmarais Céline , Dubouloz Sandra , Bichon Arnaud 
Published: October 2019

The dissemination of New Public Management principles is transforming human resources management practices in the public sector. The transformations that have taken place follow four logics: the logics of formalisation, contractualisation, individualisation and politicisation. The article examines the consequences of the interplay of these logics on the hybridisation of human resources management practices. To this end, two complementary methodologies were used: a quantitative methodology based on a survey of 223 local authorities within a French department; and a qualitative methodology based on interviews conducted with 25 of these authorities. The results show that these logics coexist, raising questions about the micro-negotiations that allow this coexistence. Points for practitioners Human resources management practices in public organisations are the composite outcome of a set of different, even contradictory, logics: the logics of individualisation, contractualisation, formalisation and politicisation. There is no common shift towards a single new human resources management model within French local authorities. The fact that these logics are always present in different combinations is explained mainly by the internal dynamics between the stakeholders (elected officials, human resources professionals, management, etc.).
Rising Trends in Emergency Department Visits Associated With Hepatitis C Virus Infection in the United States, 2006-2014
Authors: Yin Shaoman , Barker Laurie , Teshale Eyasu H. , Jiles Ruth B. 
Published: October 2019

Objective: Emergency departments (EDs) are critical settings for hepatitis C care in the United States. We assessed trends and characteristics of hepatitis C–associated ED visits during 2006-2014. Methods: We used data from the 2006-2014 Nationwide Emergency Department Sample to estimate numbers, rates, and costs of hepatitis C–associated ED visits, defined by either first-listed diagnosis of hepatitis C or all-listed diagnosis of hepatitis C. We assessed trends by demographic characteristics, liver disease severity, and patients’ disposition by using joinpoint analysis, and we calculated the average annual percentage change (AAPC) from 2006 to 2014. Results: During 2006-2014, the rate per 100 000 visits of first-listed and all-listed hepatitis C–associated ED visits increased significantly from 10.1 to 25.4 (AAPC = 13.0%; P < .001) and from 484.4 to 631.6 (AAPC = 3.4%; P < .001), respectively. Approximately 70% of these visits were made by persons born during 1945-1965 (baby boomers); 30% of visits were made by Medicare beneficiaries and 40% by Medicaid beneficiaries. Significant rate increases were among visits by baby boomers (first-listed: AAPC = 13.8%; all-listed: AAPC = 2.6%), persons born after 1965 (first-listed: AAPC = 14.3%; all-listed: AAPC = 9.2%), Medicare beneficiaries (first-listed: AAPC = 18.0%; all-listed: AAPC = 3.9%), and persons hospitalized after ED visits (first-listed: AAPC = 20.0%; all-listed: AAPC = 2.3%; all P < .001). Increasing proportions of compensated cirrhosis were among visits by baby boomers (first-listed: AAPC = 11.5%; all-listed: AAPC = 6.3%). Annual hepatitis C–associated total ED costs increased by 400.0% (first-listed) and 192.0% (all-listed) during 2006-2014. Conclusion: Public health efforts are needed to address the growing burden of hepatitis C care in the ED.
Scaling modeling and simulation on high-performance computing clusters
Authors: Mikailov Mike , Qiu Junshan , Luo Fu-Jyh , Whitney Stephen , Petrick Nicholas 
Published: October 2019

Large-scale modeling and simulation (M&S) applications that do not require run-time inter-process communications can exhibit scaling problems when migrated to high-performance computing (HPC) clusters if traditional software parallelization techniques, such as POSIX multi-threading and the message passing interface, are used. A comprehensive approach for scaling M&S applications on HPC clusters has been developed and is called “computation segmentation.” The computation segmentation is based on the built-in array job facility of job schedulers. If used correctly for appropriate applications, the array job approach provides significant benefits that are not obtainable using other methods. The parallelization illustrated in this paper becomes quite complex in its own right when applied to extremely large M&S tasks, particularly due to the need for nested loops. At the United States Food and Drug Administration, the approach has provided unsurpassed efficiency, flexibility, and scalability for work that can be performed using embarrassingly parallel algorithms.
Energy performance evaluation for benchmarking school buildings using dynamic clustering analysis and particle swarm optimization
Authors: Huang Hsu-Yao , Lin Lung-Chieh , Ke Ming-Tsun , Sathesh Tamilarasan , Lee Wen-Shing 
Published: October 2019

Benchmarking the energy performance of buildings has received increasing attention as striving for energy efficiency through more effective energy management has become a major concern of governments. Various methods for classifying building energy performance have been developed, and the clustering technique is considered one of the best approaches. This paper proposes a method utilizing dynamic clustering to analyze the electricity consumption patterns of buildings to decide the optimal cluster number and allocate the buildings to corresponding clusters for energy benchmarking. For the evaluation of number of clusters, this article has employed the inter–intra clustering method with particle swarm optimization algorithm. The electricity consumption data were collected through an energy survey performed in 30 junior high schools in Taipei, Taiwan. In a traditional method, the 30 schools would be grouped into one same cluster and the energy benchmarking report an average value of 541.4 kWh/year per student. The proposed method that took different electricity consumption patterns of the schools into consideration produced more detailed results as follows: the optimal cluster number was 3 with an inter–intra index value of 0.708, and the energy benchmarking index of these three clusters read, respectively, 362, 512, and 851 kWh/year per student. Practical application: The study proposed an innovative dynamic clustering technique to decide the optimal cluster number and allocate the assessed buildings. The results showed that compared to a traditional approach that tended to group assessed buildings into one cluster, the proposed method was able to classify the buildings into three clusters for further benchmarking. This method can be used by governments and large corporations. For example, in Hong Kong, primary schools are grouped into one cluster for energy benchmarking. Using the proposed method can further classify primary schools into more clusters; benchmarking index can then be developed for each cluster.
Retrospective evaluation of the indications, safety and effects of fresh frozen plasma transfusions in 36 cats (2014–2018)
Authors: Mansi Elizabeth T , Waldrop Jennifer E , Davidow Elizabeth B 
Published: October 2019

Objectives The goals of this study were to classify the indications, risks, effects on coagulation times and outcomes of cats receiving fresh frozen plasma (FFP) transfusions in clinical practice. Methods This was a retrospective study of FFP transfusions administered in two referral hospitals from 2014 to 2018. Transfusion administration forms and medical records were reviewed. Information was collected on indication, underlying condition, coagulation times and signs of transfusion reactions. Seven-day outcomes after FFP administration were also evaluated when available. Results Thirty-six cats received 54 FFP transfusions. Ninety-four percent of cats were administered FFP for treatment of a coagulopathy. Twenty cats had paired coagulation testing before and after FFP administration. Eighteen of these cats had improved coagulation times after receiving 1–3 units of FFP. Eight of the 36 cats had probable transfusion reactions (14.8% of 54 FFP transfusions). These reactions included respiratory signs (n = 4), fever (n = 2) and gastrointestinal signs (n = 2). Five of the eight cats with probable reactions had received packed red blood cells contemporaneously. Overall mortality rate during hospitalization was 29.7%, with 52.8% (n = 19/36) of cats confirmed to be alive 7 days after discharge. Conclusions and relevance This retrospective study shows that FFP transfusions improve coagulation times in cats. Transfusion reactions are a risk, and risk–benefit ratios must be measured prior to administration and possible reactions monitored. In the study cats, the FFP transfusions appeared to be a tolerable risk given the benefit to prolonged coagulation times.
The reorganisation of a dedicated neurourology service: An interim review
Authors: Garrod Huw , Drybrough Joe , Khadr Rauf N , Floyd Michael S 
Published: October 2019

Objective: Neuropathic bladder and urinary system pathology, such as incontinence and stone formation, are the most frequently encountered complications of spinal cord injury (SCI) and neurological disease. This study assesses the patient population and current practice at a tertiary UK neurourology service following dedicated clinic restructuring in 2017. Methods: A retrospective database was created to assess all patients attending the neurourology clinic over an 8-month period. The database recorded patient demographics, pathologies and subsequent investigations and management. Clinical innovations such as dedicated patient questionnaires and the formation of a dedicated multidisciplinary team, and their subsequent impacts on service improvement, were also assessed. Results: A total of 99 patients attended the clinic during the study. The most common pathology was SCI (51.5% (51)). The most common complaints were continence and catheter issues (61.6% (61)). Urinary symptoms such as frequency (15.2% (15)), infection (13.1% (13)) and urinary tract stones (9.1% (9)) accounted for the remainder of presenting complaints. Operative intervention was required in 25.3% (25) of cases. Conclusion: Patients with SCI and neurological disease experience a range of urinary symptoms with significant morbidity. Ensuring upper tract integrity, safe bladder management and intervening when necessary to improve quality of life are important concerns for the neurourologist. The redesigning of a dedicated neurourology clinic has permitted the treatment of such patients with a systematic approach ensuring safe bladder monitoring and upper tract surveillance. The introduction of a validated patient-reported symptom score has helped objective monitoring of symptoms before and after specific interventions. Patient concerns regarding sexual function and fertility are increasingly being encountered and addressed in the clinic. Level of evidence: 4
Biomechanical Evaluation of a Modified Internal Brace Construct for the Treatment of Ulnar Collateral Ligament Injuries
Authors: Urch Ekaterina , Limpisvasti Orr , ElAttrache Neal S. , Itami Yasuo , McGarry Michelle H. , Photopoulos Christos D. , Lee Thay Q. 
Published: October 2019

Background: Ulnar collateral ligament (UCL) repair augmented with the “internal brace” construct for the management of acute UCL injuries has recently garnered increasing interest from the sports medicine community. One concern with this technique is excessive bone loss at the sublime tubercle, should revision UCL reconstruction be required. In an effort to preserve the bony architecture of the sublime tubercle, an alternative internal brace construct is proposed and biomechanically compared with the gold standard UCL reconstruction. Hypothesis: The internal brace repair construct will restore valgus laxity and rotation to its native state and demonstrate comparable load-to-failure characteristics with the 3-strand reconstruction technique. Study Design: Controlled laboratory study. Methods: For this study, 8 matched pairs of fresh-frozen cadaveric elbows were randomized to undergo either UCL reconstruction with the 3-ply docking technique or UCL repair with a novel internal brace construct focused on augmenting the posterior band of the anterior bundle of the ligament (modified repair-IB technique). Valgus laxity and rotation measurements were quantified through use of a MicroScribe 3DLX digitizer at various flexion angles of the native ligament, transected ligament, and repaired or reconstructed ligament. Laxity testing was performed from maximum extension to 120° of flexion. Each specimen was then loaded to failure, and the method of failure was recorded. Results: Valgus laxity was restored to the intact state at all degrees of elbow flexion with the modified repair-IB technique, and rotation was restored to the intact state at both full extension and 30°. In the reconstruction group, valgus laxity was not restored to the intact state at either full extension or 30° of flexion ( P < .001 and P = .004, respectively). Laxity was restored at 60° of flexion, but the elbow was overconstrained at 90° and 120° of flexion ( P = .027 and P = .003, respectively). In load-to-failure testing, the reconstruction group demonstrated significantly greater yield torque (19.1 vs 9.0 N·m; P < .005), yield angle (10.2° vs 5.4°; P = .007), and ultimate torque (23.9 vs 17.6 N·m; P = .039). Conclusion: UCL repair with posterior band internal bracing was able to restore valgus laxity and rotation to the native state. The construct exhibited lower load-to-failure characteristics when compared with the reconstruction technique. Clinical Relevance: In selected patients with acute, avulsion-type UCL injuries, ligament repair with posterior band internal bracing is a viable alternative surgical option that, by preserving bone at the sublime tubercle, may decrease the complexity of future revision procedures.
Genomic relatedness and diversity of Swedish native cattle breeds
Authors: Upadhyay Maulik , Eriksson Susanne , Mikko Sofia , Strandberg Erling , Stålhammar Hans , Groenen Martien A. M. , Crooijmans Richard P. M. A. , Andersson Göran , Johansson Anna M. 
Published: October 2019

Abstract

Background
Native cattle breeds are important genetic resources given their adaptation to the local environment in which they are bred. However, the widespread use of commercial cattle breeds has resulted in a marked reduction in population size of several native cattle breeds worldwide. Therefore, conservation management of native cattle breeds requires urgent attention to avoid their extinction. To this end, we genotyped nine Swedish native cattle breeds with genome-wide 150 K single nucleotide polymorphisms (SNPs) to investigate the level of genetic diversity and relatedness between these breeds.

Results
We used various SNP-based approaches on this dataset to connect the demographic history with the genetic diversity and population structure of these Swedish cattle breeds. Our results suggest that the Väne and Ringamåla breeds originating from southern Sweden have experienced population isolation and have a low genetic diversity, whereas the Fjäll breed has a large founder population and a relatively high genetic diversity. Based on the shared ancestry and the constructed phylogenetic trees, we identified two major clusters in Swedish native cattle. In the first cluster, which includes Swedish mountain cattle breeds, there was little differentiation among the Fjäll, Fjällnära, Swedish Polled, and Bohus Polled breeds. The second cluster consists of breeds from southern Sweden: Väne, Ringamåla and Swedish Red. Interestingly, we also identified sub-structuring in the Fjällnära breed, which indicates different breeding practices on the farms that maintain this breed.

Conclusions
This study represents the first comprehensive genome-wide analysis of the genetic relatedness and diversity in Swedish native cattle breeds. Our results show that different demographic patterns such as genetic isolation and cross-breeding have shaped the genomic diversity of Swedish native cattle breeds and that the Swedish mountain breeds have retained their authentic distinct gene pool without significant contribution from any of the other European cattle breeds that were included in this study.