bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy, Outcomes, and Alignment Following Isolated Fibular Sesamoidectomy via a Plantar Approach
Authors: Ford Samuel E. , Adair Christopher R. , Cohen Bruce E. , Davis W. Hodges , Ellington J. Kent , Jones Carroll P. , Anderson Robert B. 
Published: August 2019

Background: The purpose of this study was to evaluate patients for intermediate-term pain relief, functional outcome, and changes in hallux alignment following isolated, complete fibular sesamoidectomy via a plantar approach for sesamoid-related pain recalcitrant to conservative treatment. Methods: A retrospective query of a tertiary referral center administrative database was performed using the Current Procedural Terminology code 28135 for sesamoidectomy between 2005 and 2016. Patients who underwent an isolated fibular sesamoidectomy were identified and contacted to return for an office visit. The primary outcome measure was change in visual analog pain score at final follow-up. Secondary measures included satisfaction, hallux flexion strength, hallux alignment, pedobarographic assessment, and postoperative functional outcome scores. Patients who met the 2-year clinical or radiographic follow-up minimum were included. Ninety fibular sesamoidectomies were identified. Thirty-six sesamoidectomies met inclusion criteria (median 60-month follow-up). The average patient was 36 years old and underwent sesamoidectomy 1.1 years after initial diagnosis. Results: Median visual analog scale scores improved 5 (6 to 1) points at final follow-up ( P < .001). Final postoperative mean hallux valgus angle did not differ from preoperative values (10.5 degrees/8.5 degrees, P = .12); similarly, the intermetatarsal angle did not differ (8.0 degrees/7.9 degrees, P = .53). Eighty-eight percent of patients would have surgery again and 70% were “very satisfied” with their result. Hallux flexion strength (mean 14.7 pounds) did not differ relative to the contralateral foot (mean 16.1 pounds) ( P = .23). Among the full 92 case cohort, 3 patients underwent 4 known reoperations. Conclusion: Fibular sesamoidectomy effectively provided pain relief (median 5-year follow-up) for patients with sesamoid pathology without affecting hallux alignment. Level of Evidence: Level IV, retrospective case series.
Serum Metabolomic Profiles of Rheumatoid Arthritis Patients With Acute-Onset Diffuse Interstitial Lung Disease
Authors: Furukawa Hiroshi , Oka Shomi , Shimada Kota , Hashimoto Atsushi , Komiya Akiko , Matsui Toshihiro , Fukui Naoshi , Tohma Shigeto 
Published: August 2019

Objective: Acute-onset diffuse interstitial lung disease (AoDILD) includes acute exacerbation of interstitial lung disease (ILD), drug-induced ILD, and Pneumocystis pneumonia, and frequently occurs in patients with rheumatoid arthritis (RA). Since AoDILD causes a poor prognosis in RA, biomarkers for AoDILD were eagerly desired. Metabolomic analyses were extensively performed in cancer patients and successfully generated better diagnostic biomarkers. In the present study, serum metabolomic profiles of AoDILD in RA were investigated to generate better potential metabolomic biomarkers. Methods: Serum samples of 10 RA patients with AoDILD were collected on admission and in a stable state, more than 3 months before the admission. Serum metabolomic analyses were conducted on the samples from these RA patients with AoDILD. Results: Apparently distinct serum metabolomic profiles in AoDILD were not observed in univariate or hierarchical cluster analyses. Partial least squares-discriminant analysis (PLS-DA) was performed to select candidate metabolites based on variable importance in projection (VIP) scores. The PLS-DA model generated from the four metabolites with VIP scores more than 2.25 (mannosamine, alliin, kynurenine, and 2-hydroxybutyric acid) could successfully discriminate AoDILD from the stable condition (area under the curve: 0.962, 95% confidence interval: 0.778–1.000). Conclusion: It was demonstrated that metabolomic profiling was useful to generate better biomarkers in AoDILD.
Health-related quality of life among patients with colorectal cancer
Authors: Sharour Loai Abu , Omari Omar Al , Salameh Ayman Bani , Yehia Dalal 
Published: August 2019

Background Up to 35% of cancer patients have clinically significant levels of psychological distress during their treatment. Accordingly, better understanding of health-related quality of life and its predictors will help oncology nurses plan appropriate interventions to improve health-related quality of life. Aims This study was conducted to investigate the relationship between hope, depression and anxiety and health-related quality of life among Jordanian cancer patients during their treatment period. Methods Cross-sectional descriptive correlational design was conducted using the Hospital Anxiety and Depression Scale, Herth Hope Index and Functional Assessment of Cancer Therapy-Colorectal surveys. Results 260 Jordanian patients with cancer from three Jordanian hospitals completed the study survey. The bivariate analysis indicated significant positive relationships between hope and quality of life ( r = .57, p < .0001). A significant negative relationship was found between anxiety and depression and quality of life ( r = −.76, p < .0001). A multiple regression analysis indicated that hope, Hospital Anxiety and Depression Scale and time since diagnosis were predictors of quality of life, and explained 66% of the variance in the quality of life for this sample. Conclusions The assessment of psychosocial elements including hope, depression, anxiety, and quality of life should be a part of daily nurse-caring behaviours and practices. Implement education programmes to increase nurses' competencies in the psychosocial assessment are recommended.
Enzymatic vitreolysis for the treatment of tractional diabetic macular edema
Authors: Pessoa Bernardete , Coelho João , Coelho Constança , Monteiro Sílvia , Abreu Carolina , Figueira João , Meireles Angelina , Melo Beirão João Nuno 
Published: August 2019

Background: A new approach to address focal vitreomacular adhesion in patients with diabetic macular edema may control and stabilize diabetic macular edema with fewer anti-vascular endothelial growth factor injections. Objectives: The aim of this study was to demonstrate that diabetic macular edema can be improved by inducing the release of a vitreomacular adhesion, with less than 2500 μm, with enzymatic vitreolysis. Methods: From a retrospective analysis of clinical records from patients with diabetic retinopathy, patients with diabetic macular edema and vitreomacular adhesion <2500 μm were selected for a single-arm prospective study. The primary endpoint was to control diabetic macular edema with fewer anti-vascular endothelial growth factor injections after an observed vitreomacular adhesion release. A statistical subanalysis was performed for the following two groups: the group with vitreomacular adhesion release (group 1) and the group without vitreomacular adhesion release (group 2). Results: A total of 23 eyes from 19 patients were included. A reduction of the median number of injections was achieved in group 1 ( p = 0.006). Adverse events were mild and transitory. Conclusion: Release of vitreomacular adhesion <2500 μm through enzymatic vitreolysis contributed to the control and stabilization of diabetic macular edema with fewer anti-vascular endothelial growth factor injections, reducing the burden and the risks related to these invasive and frequently chronic treatments.
Intragraft donor-specific anti-HLA antibodies in phenotypes of chronic lung allograft dysfunction
Authors: Sacreas Annelore , Taupin Jean-Luc , Emonds Marie-Paule , Daniëls Liesbeth , Van Raemdonck Dirk E. , Vos Robin , Verleden Geert M. , Vanaudenaerde Bart M. , Roux Antoine , Verleden Stijn E. 
Published: August 2019

IntroductionCirculating anti-human leukocyte antigen (HLA) serum donor-specific antibodies (sDSAs) increase the risk of chronic lung allograft dysfunction (CLAD) and mortality. Discrepancies between serological and pathological/clinical findings are common. Therefore, we aimed to assess the presence of tissue-bound graft DSAs (gDSAs) in CLAD explant tissue compared with sDSAs.MethodsTissue cores, obtained from explant lungs of unused donors (n=10) and patients with bronchiolitis obliterans syndrome (BOS; n=18) and restrictive allograft syndrome (RAS; n=18), were scanned with micro-computed tomography before elution of antibodies. Total IgG levels were measuredviaELISA. Anti-HLA class I and II IgG gDSAs were identified using Luminex single antigen beads and compared with DSAs found in serum samples.ResultsOverall, mean fluorescence intensity was higher in RAS eluates compared with BOS and controls (p<0.0001). In BOS, two patients were sDSA+/gDSA+and two patients were sDSA−/gDSA+. In RAS, four patients were sDSA+/gDSA+, one patient was sDSA+/gDSA−and five patients were sDSA−/gDSA+. Serum and graft results combined, DSAs were more prevalent in RAS compared with BOS (56%versus22%; p=0.04). There was spatial variability in gDSA detection in one BOS patient and three RAS patients, who were all sDSA−. Total graft IgG levels were higher in RAS than BOS (p<0.0001) and in gDSA+versusgDSA−(p=0.0008), but not in sDSA+versussDSA−(p=0.33). In RAS, total IgG levels correlated with fibrosis (r= −0.39; p=0.02).ConclusionsThis study underlines the potential of gDSA assessment as complementary information to sDSA findings. The relevance and applications of gDSAs need further investigation.
RETRACTED ARTICLE: Efficacy of pentoxifylline treatment for neonatal sepsis: a meta-analysis of randomized controlled studies
Authors: Tian Jun , Shen Peifang , Pan Kaiyu , Zhou Qiong 
Published: August 2019

Abstract
Introduction
Pentoxifylline may be an important approach to treat neonatal sepsis. However, its use has not been well established. We conduct a systematic review and meta-analysis to evaluate the efficacy of pentoxifylline treatment for neonatal sepsis.

Methods
PubMed, Embase, and the Cochrane Central Register of Controlled Trials are searched. Randomized controlled trials (RCTs) assessing the influence of pentoxifylline treatment on neonatal sepsis are included. Two investigators independently have searched articles, extracted data, and assessed the quality of included studies. This meta-analysis is performed using the random-effect model.

Results
Seven RCTs involving 439 patients are included in the meta-analysis. Compared with control intervention for neonatal sepsis, pentoxifylline treatment is associated with reduced hospital stay (Std. MD = -0.61; 95% CI = -0.93 to − 0.29; P = 0.0002) and metabolic acidosis (RR = 0.38; 95% CI = 0.22 to 0.66; P = 0.0006), but has no remarkable impact on mortality (RR = 0.59; 95% CI = 0.30 to 1.16; P = 0.13), serum TNF-α (Std. MD = -0.38; 95% CI = -1.29 to 0.52; P = 0.41), serum CRP (Std. MD = -0.25; 95% CI = -0.92 to 0.42; P = 0.47), plasma IL-6 (Std. MD = -0.13; 95% CI = -0.41 to 0.15; P = 0.37), disseminated intravascular coagulopathy (RR = 0.55; 95% CI = 0.25 to 1.21; P = 0.14), and oliguria/anuria (RR = 0.77; 95% CI = 0.28 to 2.16; P = 0.62). In addition, pentoxifylline treatment can significantly reduce mortality (RR = 0.50; 95% CI = 0.29 to 0.88; P = 0.02) after excluding the study conducted by Akdag during the sensivity analysis.

Conclusions
Pentoxifylline treatment may be associated with reduced mortality and hospital stay in neonatal sepsis.
Hyperchloremia is not associated with AKI or death in septic shock patients: results of a post hoc analysis of the “HYPER2S” trial
Authors: Commereuc Morgane , Nevoret Camille , Radermacher Peter , Katsahian Sandrine , Asfar Pierre , Schortgen Frédérique ,   HYPER2S investigators
Published: August 2019

Abstract
Background
Recent data suggest that hyperchloremia induced by fluid resuscitation is associated with acute kidney injury (AKI) and mortality, particularly in sepsis. Experimental studies showed that hyperchloremia could affect organ functions. In patients with septic shock, we examined the relationship between serum chloride concentration and both renal function and survival.

Methods
Post hoc analysis of the “HYPER2S” trial database (NCT01722422) including 434 patients with septic shock randomly assigned for resuscitation with 0.9% or 3% saline. Metabolic parameters were recorded up to 72 h. Metabolic effects of hyperchloremia (> 110 mmol/L) were studied stratified for hyperlactatemia (> 2 mmol/L). Cox models were constructed to assess the association between chloride parameters, day-28 mortality and AKI.

Results
413 patients were analysed. The presence of hyperlactatemia was significantly more frequent than hyperchloremia (62% versus 71% of patients, respectively, p = 0.006). Metabolic acidosis was significantly more frequent in patients with hyperchloremia, no matter the presence of hyperlactatemia, p < 0.001. Adjusted risk of AKI and mortality were not significantly associated with serum chloride, hyperchloremia, maximal chloremia and delta chloremia (maximal-H0 [Cl]).

Conclusions
Despite more frequent metabolic acidosis, hyperchloremia was not associated with an increased risk for AKI or mortality.
Trial registration ClinicalTrials.gov, identifier: NCT01722422, registered 2 November 2012
Prenatal Testosterone Excess Disrupts Placental Function in a Sheep Model of Polycystic Ovary Syndrome
Authors: Kelley Angela S , Puttabyatappa Muraly , Ciarelli Joseph N , Zeng Lixia , Smith Yolanda R , Lieberman Richard , Pennathur Subramaniam , Padmanabhan Vasantha 
Published: August 2019

Abstract
Polycystic ovary syndrome (PCOS) is a common condition of reproductive-aged women. In a well-validated sheep model of PCOS, testosterone (T) treatment of pregnant ewes culminated in placental insufficiency and intrauterine growth restriction of offspring. The purpose of this study was to explore specific mechanisms by which T excess compromises placental function in early, mid, and late gestation. Pregnant Suffolk sheep received T propionate 100 mg intramuscularly or control vehicle twice weekly from gestational days (GD) 30 to 90 (term = 147 days). Placental harvest occurred at GD 65, 90, and 140. Real-time RT-PCR was used to assess transcript levels of proinflammatory (TNF, IL1B, IL6, IL8, monocyte chemoattractant protein-1/chemokine ligand 2, cluster of differentiation 68), antioxidant (glutathione reductase and superoxide dismutase 1 and 2), and angiogenic [vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1α (HIF1A)] genes. Lipid accumulation was assessed using triglyceride assays and Oil Red O staining. Placental measures of oxidative and nitrative stress included the thiobarbituric acid reactive substance assay and high-pressure liquid chromatography. Tissue fibrosis was assessed with Picrosirius Red staining. Student t tests and Cohen effect-size analyses were used for statistical analysis. At GD 65, T-treated placentomes showed increased lipid accumulation and collagen deposition. Notable findings at GD 90 were a significant increase in HIF1A expression and a large effect increase in VEGF expression. At GD 140, T-treated placentomes displayed large effect increases in expression of hypoxia and inflammatory markers. In summary, T treatment during early pregnancy induces distinct gestational age-specific effects on the placental milieu, which may underlie the previously observed phenotype of placental insufficiency.
Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours
Authors: Pervolaraki Eleftheria , Hall Stephen P. , Foresteire Denise , Saito Takashi , Saido Takaomi C. , Whittington Miles A. , Lever Colin , Dachtler James 
Published: August 2019

ABSTRACT
We studied a new amyloid-beta precursor protein (App) knock-in mouse model of Alzheimer's disease (AppNL-G-F), containing the Swedish KM670/671NL mutation, the Iberian I716F mutation and the Artic E693G mutation, which generates elevated levels of amyloid beta (Aβ)40 and Aβ42 without the confounds associated with APP overexpression. This enabled us to assess changes in anxiety-related and social behaviours, and neural alterations potentially underlying such changes, driven specifically by Aβ accumulation. AppNL-G-F knock-in mice exhibited subtle deficits in tasks assessing social olfaction, but not in social motivation tasks. In anxiety-assessing tasks, AppNL-G-F knock-in mice exhibited: (1) increased thigmotaxis in the open field (OF), yet; (2) reduced closed-arm, and increased open-arm, time in the elevated plus maze (EPM). Their ostensibly anxiogenic OF profile, yet ostensibly anxiolytic EPM profile, could hint at altered cortical mechanisms affecting decision-making (e.g. ‘disinhibition’), rather than simple core deficits in emotional motivation. Consistent with this possibility, alterations in microstructure, glutamatergic-dependent gamma oscillations and glutamatergic gene expression were all observed in the prefrontal cortex, but not the amygdala, of AppNL-G-F knock-in mice. Thus, insoluble Aβ overexpression drives prefrontal cortical alterations, potentially underlying changes in social and anxiety-related behavioural tasks.
This article has an associated First Person interview with the first author of the paper.
Amino Acids and Peptides as Functional Components in Arylenediimide-Based Molecular Architectonics
Authors: Roy Bappaditya , Govindaraju Thimmaiah 
Published: August 2019

Abstract
Molecular architectonics has its essence in custom design and engineering of molecular assemblies by judicious exploitation of the noncovalent forces to construct ordered architectures with novel properties and functions. The art of mastering the programmed molecular assemblies is a challenging task owing to complex factors that govern recognition events at the molecular level. In this context, biomolecules with in-built information for molecular recognition are capable of guiding the molecular architectonics to construct nano, micro, and macro-architectures with functional properties and applications. In particular, amino acids and peptides are attractive auxiliaries to guide the controlled molecular self-assembly, coassembly, heterostructures and living assembly systems of functional molecules in the scheme of molecular architectonics. Use of these exquisite biomolecular auxiliaries to master the art of engineering the molecular assembly of functional aromatic units viz., arylenediimides has been a continuous effort in the emerging field of molecular architectonics. In this accounts article, we outline the amino acid and peptide functionalized arylenediimide-based designer molecular systems as functional modular units developed by our group and others with an objective to demonstrate the concept of molecular architectonics to construct functional nano, micro and macroarchitectures with wide range of properties and applications.
Psycho-social predictors of acculturative stress and adjustment in Pakistani Institutions
Authors: Riaz Muhammad Akram , Rafique Rafia 
Published: August 2019

Objectives: The main objective of study was to investigate the effect of psycho-social predictors on acculturative stress and adjustment in Pakistani institutions.
Methods: The study was carried out from November 15, 2016 to January 18, 2019. For this purpose data was collected from 450 international students who were studying in public and private sector universities of Pakistan and who experienced acculturative stress. The instruments include Relationship Assessment Scale, Acculturative Stress Scale for International, Psychological Adaptation Scale, and Revised Socio Cultural Adaptation Scale. The proposed model was tested by using SPSS (Version-23) and AMOS (Version-9).
Results: Findings of the study revealed that relationship satisfaction (p<0.05), length of stay (p<0.05), and financial support (p<0.05) significantly negatively predicted acculturative stress. Financial support significantly positively predicted psychological adjustment (p<0.05). Employment status did not predict acculturative stress, psychological and socio-cultural adjustment (p>0.05). Moreover, all psycho-social predictors did not show effect on socio-cultural adjustment among international students (p>0.05).
Conclusion: It can be concluded that general relationship satisfaction, more length of stay in host country, and financial support are very important for international students to manage their acculturative stress and to adjust better in a new cultural environment.
doi: https://doi.org/10.12669/pjms.35.5.1214
How to cite this:Riaz MA, Rafique R. Psycho-social predictors of acculturative stress and adjustment in Pakistani Institutions. Pak J Med Sci. 2019;35(5):1441-1445. doi: https://doi.org/10.12669/pjms.35.5.1214
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comparison of radial shockwave and dry needling therapies in the treatment of myofascial pain syndrome
Authors: Sukareechai Chomkajee , Sukareechai Somchai 
Published: August 2019

Background/Aims Myofascial pain syndrome is a frequent problem in the musculoskeletal system. As a method of treatment for myofascial pain syndrome, dry needling therapy is an effective and convenient treatment for patients because they do not need to be treated every day. However, as patients often have post-needle soreness or some patients are afraid of needles, there are limitations to this treatment. The purpose of this study is to compare the effectiveness of radial shockwave therapy with dry needling therapy to treat myofascial pain. Methods A total of 42 patients attending the rehabilitation department with at least one myofascial pain trigger point in their upper back muscles, were randomly assigned to receive radial shockwave therapy or dry needling therapy. Treatment was performed once a week for 3 weeks in both groups. Participants' pain pressure threshold, measured using an algometer, and pain levels, measured using a numeric pain scale, were assessed before the designated treatment was applied each week. Each patient also performed upper trapezius, rhomboid and infraspinatus muscle stretches twice a day throughout the study period. Results There was no difference in pain pressure threshold at the three trigger points before treatment with the different modalities commenced. At the end of the study, the radial shockwave therapy group had a significant improvement in trapezius pain pressure threshold, increasing from 11.7 at baseline to 14.8 at the end of study. There was no significant between-group difference in pain level (P=3.4 vs P=2.6) at the end of the study. Both treatments significantly reduced pain levels: from 7.2 to 3.4 in the radial shockwave group (P<0.001) and from 6.8 to 2.6 in the dry needling therapy group (P<0.001). Conclusions Dry needling and radial shock wave therapies are effective in reducing myofascial pain syndrome originating in the upper back muscles. Participants' pain pressure threshold increased after 3 weeks of treatment with both therapies. Radial shock therapy can be used as an alternative to dry needling in the treatment of myofascial pain syndrome in patients who have trouble attending daily physical therapy or in whom dry needling therapy is contraindicated.
A “Epopeia Gilgamesh” é uma epopeia?
Authors: Lins Brandão Jacyntho 
Published: August 2019

Uma vez que o poema de gilgámesh existiu em seu próprio mundo, tanto quanto no nosso, este artigo discute e pertinência de aplicar-lhe o rótulo de épico. Do ponto de vista moderno, essa classificação depende da aproximação com a épica grega arcaica e responde à necessidade de situar o texto num conjunto de gêneros conhecidos, orientando sua recepção. Da perspectiva babilônica antiga, o rótulo épico parece inadequado e proponho que se entenda o poema como a contraparte literária de um narû, do que se chama “autobiografia em terceira pessoa”.
Palavras-chave: poema de gilgámesh; épica grega; autobiografia em terceira pessoa.