bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linear IgA dermatosis in association with angioimmunoblastic T‐cell lymphoma infiltrating the skin: A case report with literature review
Authors: Colmant Caroline , Camboni Alessandra , Dekeuleneer Valérie , Marot Liliane , Dachelet Claire , Baeck Marie 
Published: September 2019

AbstractAngioimmunoblastic T‐cell lymphoma (AITL) is an aggressive form of peripheral T‐cell lymphoma, characterized by systemic symptoms, diffuse lymphadenopathy, hepatosplenomegaly and immunodysregulation. Half of AITL is associated with cutaneous symptoms, but only few cases with bullous eruption have been described. Association with a linear IgA dermatosis is extremely rare. Linear IgA dermatosis can be idiopathic, or linked with drug intake or neoplastic disorders. Some cases of linear IgA dermatosis presenting as toxic epidermal necrolysis (TEN) have been described, most of them being drug induced. We here present the case of a 72‐year‐old man recently diagnosed with AITL who developed a bullous eruption, presenting as TEN. Histopathology showed deep cutaneous involvement of the lymphoma with a sub‐epidermal blistering and direct immunofluorescence revealed a heavy IgA linear deposit on the dermal‐epidermal junction. A diagnosis of linear IgA dermatosis associated with cutaneous involvement of an angioimmunoblastic T‐cell lymphoma was made. Chemotherapy and corticosteroids allowed cutaneous improvement but the patient died of his lymphoma shortly after.
Temporal dynamics of taxonomic homogenization in the fish communities of the Laurentian Great Lakes
Authors: Campbell Sara E. , Mandrak Nicholas E. 
Published: September 2019

AbstractAimAs a result of the loss of native species and the spread of non‐native species, fish communities are becoming increasingly homogenous globally. In the Laurentian Great Lakes, 21 native fish species have been extirpated from one or more lakes as a result of habitat alteration and destruction, overexploitation and invasive species since the 1800s. Over the same time period, 30 non‐native species became established in at least one lake as a result of authorized and unauthorized introductions. This study examines temporal changes in taxonomic dissimilarity over 15 time periods spanning the last 150 years.LocationLaurentian Great Lakes, North America.MethodsChanges to the Great Lakes fish fauna were summarized in species lists by decade from 1870 to 2010. Taxonomic dissimilarity between and within communities was calculated using Jaccard's dissimilarity coefficient; the relative contribution of turnover (species replacement) and nestedness (species loss) to total taxonomic dissimilarity was also calculated. To test whether the Great Lakes have homogenized, we conducted a regression on multiple‐site dissimilarity values over time.ResultsNative species richness in the Great Lakes exhibits a latitudinal gradient that reflects post‐glacial history and current climate. We demonstrate that the establishment of non‐native species and extirpation of native species has changed fish communities in each of the Great Lakes, with communities in Lake Superior differentiating the most (~23%) and in Lake Ontario the least (~12%) since 1870. Multiple‐site dissimilarity ranges between ~50% and 53% per decade, and communities have become ~5.9% more similar over time since 1870.Main ConclusionsSpecies introductions and extirpations have changed community composition, resulting in the fish communities becoming significantly more similar to one another over time and, thus, homogenized. As a result, ongoing management should prevent range expansion of native and non‐native species to preserve the current distinctiveness of the Great Lakes fish communities.
Doing a transversal method: developing an ethics of care in a collaborative research project
Authors: SCHEEL STEPHAN , GROMMÉ FRANCISCA , RUPPERT EVELYN , USTEK‐SPILDA FUNDA , CAKICI BAKI , TAKALA VILLE 
Published: September 2019

AbstractBeck and Sznaider call on ‘methodological cosmopolitanism’ to transcend methodological nationalism and account for an increasingly cosmopolitanized reality. We take up their challenge by drawing on our experiences of conducting a collaborative ethnography of methodological changes in the production of population statistics within and between European national and international statistical institutes. Drawing on debates in science and technology studies, we depart from some conceptual presuppositions of methodological cosmopolitanism to define a ‘transversal method’. Referring to this method as performative and ontopolitical, we reflect on how it requires collaboration and, in our ethnography, gave rise to three practical challenges – (1) going beyond the individual project; (2) using each other's field notes; (3) and working against the national order of things. To meet these challenges, we reflect on how this method required us to practise three modes of care – thinking with others, tinkering with field notes, and dissenting within.
Doing Public Criminology with the Criminal Justice Voluntary Sector: Methodological Reflections and Considerations
Authors: McALEESE SAMANTHA 
Published: September 2019

AbstractCriminological literature outlines various roles for public criminologists and reflects on both the form and purpose of public criminology. This article reviews this literature and considers institutional and political activist ethnography as methods through which criminologists can address critique, and better combine social justice research and advocacy work. Such methodological considerations demonstrate that, for some, ‘doing’ public criminology means actively engaging in advocacy work alongside research participants and other activists. Examples and reflections from the author's own work with the criminal justice voluntary sector (CJVS) in Canada demonstrate that a public criminology informed by institutional and political activist ethnography is especially important if we want to: (i) better understand the role of the sector in supporting people with criminal records; and (ii) strengthen the relationship between academics, policymakers, advocates, practitioners, and people with lived experience of criminalisation and punishment.
From an assessment of multiple chelators, clodronate has potential for use in continuous chelation
Authors: Wright P. P. , Cooper C. , Kahler B. , Walsh L. J. 
Published: September 2019

AbstractAimTo identify chelators which when mixed with sodium hypochlorite (NaOCl) are stable, exhibiting minimal loss of free available chlorine (FAC) over 80 min and to further investigate potential mixtures by assessing FAC over 18 h and the capacity to remove smear layer.Methodology0.25 mol L−1 EDTA (10%), 0.25 mol L−1 EGTA (egtazic acid), 0.25 mol L−1 CDTA (cyclohexanediaminetetraacetic acid), 0.25 mol L−1 DTPA (pentetic acid), 0.5 mol L−1 ATMP (aminotri(methylene phosphonic acid)) and 1 mol L−1 HPAA, (hydroxyphosphonoacetic acid), all at alkaline pH, were mixed equally with 5% NaOCl. 0.5 mol L−1 alkaline clodronate and 0.5 mol L−1 Na4etidronate (15%) were mixed equally with 10% NaOCl. For all mixtures, the pH and temperature were measured over 80 min and additionally for the clodronate mixture over 18 h. Iodometric titration was used to measure the FAC of all mixtures except for HPAA. The following were compared with respect to their ability to remove smear layer: 1 mol L−1 clodronate + 10% NaOCl, 0.5 mol L−1 clodronate + 10% NaOCl, 1 mol L−1 etidronate + 10% NaOCl, 0.5 mol L−1 clodronate + 10% NaOCl and the sequences 5% NaOCl/17% EDTA/5% NaOCl and 5% NaOCl/17% EDTA. The area fraction occupied by open dentinal tubules as a percentage of the total area (% AF) from scanning electron microscopy micrographs was calculated using Image J. The results were statistically analysed with alpha set at 0.05.ResultsCompared to its control, the mixture 0.5 mol L−1 clodronate + 10% NaOCl lost no FAC over 18 h (P > 0.05). The FAC of 0.25 mol L−1 CDTA mixed with 5% NaOCl fell to 96%, 92%, 75% and 4.9% at 20, 40, 60 and 80 min, respectively. Temperature rises were observed in all cases except in the etidronate and clodronate mixtures. Only in the clodronate mixture did the pH remain above pH 12 for the whole experiment. Although smear layer was removed, the % AF in 1 mol L−1 clodronate + 10% NaOCl, 0.5 mol L−1 clodronate + 10% NaOCl, 1 mol L−1 etidronate + 10% NaOCl was less than for 0.5 mol L−1 etidronate + 10% NaOCl and 5% NaOCl/17% EDTA/5% NaOCl and 5% NaOCl/17% EDTA.ConclusionAlkaline 0.5 mol L−1 clodronate mixed equally with 10% NaOCl has potential for use in continuous chelation, based on this assessment of stability and smear layer removal. Further research is needed to establish its efficacy and safety.
Monogenic leptin deficiency in early childhood obesity
Authors: ElSaeed Gehan , Mousa Noha , El‐Mougy Fatma , Hafez Mona , Khodeera Seham , Alhelbawy Mohamed , Fouda Engy , Elsheikh Suzan , ElKaffas Rasha , Eldeeb Sara , Elsharkawy Marwa 
Published: September 2019

SummaryBackgroundEarly childhood obesity is a public health problem worldwide. It affects different aspects of physical and mental child's health. Identifying the etiologies, especially treatable and preventable causes, can direct health professionals toward proper management. Analysis of serum leptin levels and leptin gene mutations is a rapid and easy step toward the diagnosis of congenital leptin deficiency that is considered an important cause in early childhood obesity.ObjectivesThe aim of this study was to diagnose monogenic leptin deficiency in Egyptian children presenting with early onset obesity (EOO).MethodsThe current cross‐sectional study included 80 children who developed obesity during the first year of life with BMI > 2 SD (for age and sex). The studied population was subjected to history taking, auxological assessment, serum leptin assay, and leptin gene sequencing.ResultsTen cases had leptin deficiency (12.5%), while 18 cases showed elevated leptin levels (22.5%). Leptin gene variants in the coding region were identified in 30% of the leptin‐deficient group: two novel homozygous disease‐causing variants (c.104 T > G and c.34 delC) and another previously reported homozygous pathogenic variant (c.313C > T).ConclusionLeptin deficiency is considered a significant cause of monogenic obesity in Egyptian children with early‐onset obesity as the diagnosis of these patients would be a perfect target for recombinant leptin therapy.
Impact of negative‐pressure wound therapy on bacterial behaviour and bioburden in a contaminated full‐thickness wound
Authors: Li Zhirui , Yu Qingwen , Wang Song , Wang Guoqi , Li Tongtong , Tang Pei‐fu , Liu Daohong 
Published: September 2019

AbstractThe use of negative‐pressure wound therapy (NPWT) has displayed significant clinical benefits in the healing of infected wounds. However, the effects of NPWT on bacterial colonisation and infection of traumatic wounds has been controversial. The aim of this study is to evaluate the impact of NPWT treatment in rabbits with a contaminated full‐thickness wound on bacterial behaviour, including colony morphology, spatial distribution, fissional proliferation, and bacterial bioburden. Full‐thickness wounds were created on the back of rabbits, and were inoculated with bioluminescent Staphylococcus aureus. The wounds were treated with sterile gauze dressings and NPWT with continuous negative pressure (−125 mm Hg). Wound samples were harvested on days 0 (6 hours after bacterial inoculation), 2, 4, 6, and 8 at the centre of wound beds before irrigation. Scanning electron microscopy and transmission electron microscopy (TEM) analyses were performed to determine the characteristic bacteriology. Laser scanning confocal microscopy was performed to obtain bioluminescent images, which were used to observe spatial distribution of the GFP‐labelled S. aureus within the tissue and quantify the bacterial bioburden. NPWT resulted in sparse amounts of scattered bacteria on the wound surface or as sparsely spaced single colonies within the tissue. Wound bioburden on day 8 in the NPWT and gauze groups was 34.6 ± 5.5% and 141.9 ± 15.4% of the baseline values (N = 6), respectively (P < .0001). TEM showed a lack of S. aureus active fission within NPWT‐treated tissue. NPWT can impact S. aureus colony morphology and spatial distribution both on the surface and within wound tissue, and reduce S. aureus as early as 48 hours after therapy initiation. Additionally, NPWT inhibits bacterial fissional proliferation in microcolonies.
Host genotype and amoxicillin administration affect the incidence of diarrhoea and faecal microbiota of weaned piglets during a natural multiresistant ETEC infection
Authors: Massacci Francesca Romana , Tofani Silvia , Forte Claudio , Bertocchi Micol , Lovito Carmela , Orsini Serenella , Tentellini Michele , Marchi Lucia , Lemonnier Gaetan , Luise Diana , Blanc Fany , Castinel Adrien , Bevilacqua Claudia , Rogel‐Gaillard Claire , Pezzotti Giovanni , Estellé Jordi , Trevisi Paolo , Magistrali Chiara Francesca 
Published: September 2019

AbstractEnterotoxigenic Escherichia coli (ETEC) is the aetiological agent of postweaning diarrhoea (PWD) in piglets. The SNPs located on the Mucine 4 (MUC4) and Fucosyltransferase 1 (FUT1) genes have been associated with the susceptibility to ETEC F4 and ETEC F18, respectively. The interplay between the MUC4 and FUT1 genotypes to ETEC infection and the use of amoxicillin in modifying the intestinal microbiota during a natural infection by multiresistant ETEC strains have never been investigated. The aim of this study was to evaluate the effects of the MUC4 and FUT1 genotypes and the administration of amoxicillin through different routes on the presence of diarrhoea and the faecal microbiota composition in piglets naturally infected with ETEC. Seventy‐one piglets were divided into three groups: two groups differing by amoxicillin administration routes—parenteral (P) or oral (O) and a control group without antibiotics (C). Faecal scores, body weight, presence of ETEC F4 and F18 were investigated 4 days after the arrival in the facility (T0), at the end of the amoxicillin administration (T1) and after the withdrawal period (T2). The faecal bacteria composition was assessed by sequencing the 16S rRNA gene. We described that MUC4 and FUT1 genotypes were associated with the presence of ETEC F4 and ETEC F18. The faecal microbiota was influenced by the MUC4 genotypes at T0. We found the oral administration to be associated with the presence of diarrhoea at T1 and T2. Furthermore, the exposure to amoxicillin resulted in significant alterations of the faecal microbiota. Overall, MUC4 and FUT1 were confirmed as genetic markers for the susceptibility to ETEC infections in pigs. Moreover, our data highlight that group amoxicillin treatment may produce adverse outcomes on pig health in course of multiresistant ETEC infection. Therefore, alternative control measures able to maintain a healthy faecal microbiota in weaners are recommended.
Bayesian Extension of Biweight and Huber Weight for Robust Ability Estimation
Authors: Maeda Hotaka , Zhang Bo 
Published: September 2019

AbstractWhen a response pattern does not fit a selected measurement model, one may resort to robust ability estimation. Two popular robust methods are biweight and Huber weight. So far, research on these methods has been quite limited. This article proposes the maximum a posteriori biweight (BMAP) and Huber weight (HMAP) estimation methods. These methods use the Bayesian prior distribution to compensate for information lost due to aberrant responses. They may also be more resistant to the detrimental effects of downweighting the nonaberrant responses. The effectiveness of BMAP and HMAP was evaluated through a Monte Carlo simulation. Results show that both methods, especially BMAP, are more effective than the original biweight and Huber weight in correcting mild forms of aberrant behavior.
The potential of runoff attenuation features as a Natural Flood Management approach
Authors: Nicholson Alexander R. , O'Donnell Greg M. , Wilkinson Mark E. , Quinn Paul F. 
Published: September 2019

AbstractNatural Flood Management (NFM) is receiving much attention in the United Kingdom and across Europe and is now widely seen as a valid solution to help sustainably manage flood risk whilst offering significant multiple benefits. However, there is little empirical evidence demonstrating the effectiveness of NFM interventions in reducing flood hazard at the catchment scale. The Belford Burn catchment (~6km2) in Northern England provides a focus for this article, and utilises observed data collected throughout the NFM project's monitoring period (2007–2012). This study discusses the introduction of catchment‐wide water storage through the implementation of runoff attenuation features (RAFs), in‐particular offline storage areas, as a means of mitigating peak flow magnitudes in flood‐causing events. A novel experimental monitoring setup is introduced alongside an analytical approach to quantify the impact of individual offline storage areas, which has demonstrated local reductions in peak flow for low magnitude storm events. Finally, a physically based model has been created to demonstrate the impact of a network of offline storage areas to enable assessment of storage thresholds required to mitigate design storm events, thus enabling design of an NFM scheme. The modelling results have shown that peak flow can be reduced by more than 30% at downstream receptors.
Disaster waste management after flood events
Authors: Amato Alessia , Gabrielli Francesco , Spinozzi Francesco , Magi Galluzzi Lorenzo , Balducci Susanna , Beolchini Francesca 
Published: September 2019

AbstractLarge amounts of waste debris occur in urbanised areas when heavy rain on local geology generates flooding and landslides. Improved understanding of disaster waste management helps to support future strategies. This study aims to find management solutions that are environmentally and economically sustainable, hypothesizing three different options. There are many variables which influence the environmental impact and the operational cost. The distances between the areas of interest and the management site, the extent of a first manual sorting carried out by citizens, the economic load of each involved step. Overall, both the environmental and the economic analysis confirmed the usefulness of the non‐advanced option, which includes a temporary debris storage site for a preliminary shredding. On the other hand, the impact due to a possible biological treatment is not balanced by the advantage of the further volume decrease. The article shows a simple analysis schema, easily adaptable to different geographical context, is useful as supporting tool for the decision makers in flood emergency scenarios.
Effect of fermented blood cells on growth performance and intestinal characteristics of weaned piglets
Authors: Zhang Boru , Yang Wei , Zhang Hongyun , Meng Qingwei , Bi Chongpeng , Shan Anshan 
Published: September 2019

AbstractThe increase in feed costs has led feeder to replace protein source. Blood meal can be used in piglet diets instead of fish meal (FM). The objective of this study was to investigate the effect of fermented blood cells (FBCs) on the growth performance and intestinal health of weaned piglets. One hundred eighty 28‐day‐old piglets were assigned and were divided into 4 groups (9 L per groups and 5 pigs per litters) randomly. The piglets were fed one of four experimental diets, fish meal, blood cells (BCs), liquid‐state fermented blood cells (LFBCs) or solid‐state fermented blood cells (SFBCs) respectively. The dietary with LFBCs and SFBCs increased the average daily gain and feed intake (ADFI) and average daily gain (ADG) (p < .05). In duodenum, LFBC group increased the villous height (p < .05). The SFBC and LFBC group significantly increased the villous height (p < .05) in the jejunum. Fermented blood cells exhibit a positive regulatory function on the intestinal tract and modulate intestinal microflora. Compared with the fish meal group, the CAT, GSH‐PX and SOD activity, and MDA level was no significant differences in jejunum and plasma of weaned piglets (p > .05). LFBCs and SFBCs significantly increased the bifidobacteria and lactobacillus number in the caecum (p < .05). Dietary LFBCs increased the expression of ZO‐1 mRNA in the jejunal of weaned piglets (p < .05). In conclusion, dietary with fermented blood cells in weaned piglets had improved growth performance and intestinal health of weaned piglets.
Comparative study of stress response, growth and development of uteri in post‐weaning gilts challenged with zearalenone and estradiol benzoate
Authors: Zhou Min , Yang Lijie , Chen Yanhong , Sun Tong , Wang Nuan , Chen Xing , Yang Zaibin , Ge Jinshan , Jiang Shuzhen 
Published: September 2019

AbstractThe objective of this study was to evaluate the effects of zearalenone (ZEA) and estradiol benzoate (EB) on stress injury and uterine development in post‐weaning gilts. Thirty healthy post‐weaning female gilts (Duroc × Landrace × Large White) aged 28–32 days were randomly allocated to three treatments as follows: (a) basal diet (Control), (b) basal diet plus 1.0 mg/kg purified ZEA (ZEA) and (c) basal diet plus 0.75 ml (1.5 mg) EB per pig at 3‐days intervals by intramuscular injection (EB). The serum estradiol (E2), the final and the increased vulvar area, uterine index, thickness of the myometrium and endometrium, and protein expression of heat shock protein 70 (HSP70) in ZEA group were higher than those in the control group (p < .05), but lower than those in the EB group (p < .05). The serum luteinizing hormone in ZEA group was lower than that of the control group (p < .05), but higher than that in the EB group (p < .05). Higher serum follicle‐stimulating hormone and progesterone were observed in the ZEA and control groups than those in the EB group (p < .05). The serum glutathione peroxidase activity in the ZEA group was lower than that in the control and EB groups (p < .001), and the malondialdehyde in the ZEA group was higher than that in the control and EB groups (p < .001). Moreover, the relative mRNA and protein expression of growth hormone receptor (GHR) and relative mRNA expression of HSP70 in the ZEA and EB groups were higher than those in the control group (p < .05). In conclusion, both ZEA (1.0 mg/kg) and EB (1.5 mg at 3 days intervals by intramuscular injection) stimulated vulvar swelling and uterine hypertrophy by disordering serum hormones and up‐regulating GHR expression, and induced stress by different mechanisms in this study. Furthermore, the observed up‐regulating HSP70 expression challenged by ZEA or EB may be part of the mechanism to resist stress injury.