bluuebunny/crossref_metadata_2025_split huggingface dataset:
An alternative interpretation of the exomoon candidate signal in the combined Kepler and Hubble data of Kepler-1625
Authors: Heller René , Rodenbeck Kai , Bruno Giovanni 
Published: March 2019

Context. Kepler and Hubble photometry of a total of four transits by the Jupiter-sized exoplanet Kepler-1625 b have recently been interpreted to show evidence of a Neptune-sized exomoon. The key arguments were an apparent drop in stellar brightness after the planet’s October 2017 transit seen with Hubble and its 77.8 min early arrival compared to a strictly periodic orbit.
Aims. The profound implications of this first possible exomoon detection and the physical oddity of the proposed moon, i.e., its giant radius prompt us to examine the planet-only hypothesis for the data and to investigate the reliability of the Bayesian information criterion (BIC) used for detection.
Methods. We combined Kepler’s Pre-search Data Conditioning Simple Aperture Photometry (PDCSAP) with the previously published Hubble light curve. In an alternative approach, we performed a synchronous polynomial detrending and fitting of the Kepler data combined with our own extraction of the Hubble photometry. We generated five million parallel-tempering Markov chain Monte Carlo (PTMCMC) realizations of the data with both a planet-only model and a planet-moon model, and compute the BIC difference (ΔBIC) between the most likely models, respectively.
Results. The ΔBIC values of − 44.5 (using previously published Hubble data) and − 31.0 (using our own detrending) yield strong statistical evidence in favor of an exomoon. Most of our orbital realizations, however, are very different from the best-fit solutions, suggesting that the likelihood function that best describes the data is non-Gaussian. We measure a 73.7 min early arrival of Kepler-1625 b for its Hubble transit at the 3 σ level. This deviation could be caused by a 1 d data gap near the first Kepler transit, stellar activity, or unknown systematics, all of which affect the detrending. The radial velocity amplitude of a possible unseen hot Jupiter causing the Kepler-1625 b transit timing variation could be approximately 100 m s−1.
Conclusions. Although we find a similar solution to the planet-moon model to that previously proposed, careful consideration of its statistical evidence leads us to believe that this is not a secure exomoon detection. Unknown systematic errors in the Kepler/Hubble data make the ΔBIC an unreliable metric for an exomoon search around Kepler-1625 b, allowing for alternative interpretations of the signal.
Comprehensive Coagulation Profiling at the Point-of-Care Using a Novel Laser-Based Approach
Authors: Nadkarni Seemantini 
Published: March 2019

AbstractDelays in identifying internal bleeding are life-threatening, thus underscoring the need for rapid and comprehensive coagulation profiling at the bedside. The authors review a novel optical coagulation profiler that measures several coagulation metrics including prothrombin time, activated clotting time, clot polymerization rate (α-angle), clot stiffness (maximum amplitude), fibrinolysis (LY), and platelet function, using a single multifunctional instrument. The optical profiler is based on the principles of Laser Speckle Rheology that quantifies tissue viscoelasticity from light scattering patterns called laser speckle. To operate the optical profiler, whole blood (40 μL) is loaded into a disposable cartridge, laser speckle patterns are recorded via a camera, and the viscoelasticity of clotting blood is estimated from speckle intensity fluctuations. By monitoring alterations in viscoelastic moduli over time during clot initiation, thrombin generation, fibrin crosslinking, clot stabilization, and LY, global coagulation parameters are obtained within 10 minutes using a drop of whole blood. Clinical testing in over 500 patients to date has confirmed the accuracy of the optical profiler for comprehensively assessing coagulation status against conventional coagulation tests and thromboelastography. Recent studies have further demonstrated the capability to quantify platelet aggregation induced by adenosine diphosphate in a drop of platelet-rich-plasma in the absence of applied shear stress. Together, these studies demonstrate that global coagulation profiling in addition to platelet function may be accomplished using a single multifunctional device. Thus, by enabling rapid and comprehensive coagulation and platelet function profiling at the bedside, the optical profiler will likely advance the capability to identify and manage patients with an elevated risk for hemorrhage.
Disharmony in harmony with diachronic stability
Authors: Djamouri Redouane , Paul Waltraud 
Published: March 2019

Abstract
Chinese is an intriguing case of syntactic stability. Since the earliest available documents (13th c. BC) up to today, it has displayed SVO order in combination with a head final NP as well as – in subsequent stages – other phenomena said to be typical of SOV languages, such as postpositions (since 1st c. BC) and a head-final CP (since 5th c. BC). This contradicts the received wisdom in the literature that highly ‘disharmonic’ stages are unstable and liable to change towards a (more) ‘harmonic’ one. Taking Chinese as a starting point, the assumption that the concept of stability itself – although inaccessible to the child acquirer and only observable with hindsight by the linguist – is an inbuilt part of human language and hence of universal grammar, is shown to be wrong.
A variational theory of specialization in acquisition and diachrony
Authors: Wallenberg Joel C. 
Published: March 2019

Abstract
This article presents an empirical case study in the diachronic specialization of morphosyntactic forms for different syntactic contexts, and uses it to develop a theory of variational specialization. This theory links specialization in diachrony to specialization in language acquisition, sociolinguistic coordination in a speech community, and a general understanding of evolutionary dynamics. The case study illustrates these relationships with the specialization of melted and molten in Early Modern English, and tests the hypothesis that even diachronic specialization in a lexical domain will not take the same trajectory for different speakers, but that the community will nevertheless coordinate on a direction of specialization given multiple generations. In doing so, it answers a question referred to as Yang’s Paradox: how can we reconcile diachronic results showing that specialization is slow, with experimental results on acquisition showing that it’s fast? The study ultimately shows that specialization in a speech community is orders of magnitude slower than specialization for an individual child in an experimental setting, due to the problem of coordinating the dimension and direction of specialization among many speakers. I also show how Yang’s (2000) variational grammar learning model can be extended to the problem of specialization, and that children plausibly do not play an active role in specializing linguistic forms: they only need to identify potential contexts that the forms could specialize for, and the learning analog of natural selection does the rest.
Stable variation in multidimensional competition
Authors: Kauhanen Henri 
Published: March 2019

Abstract
The Fundamental Theorem of Language Change (Yang 2000) implies the impossibility of stable variation in the Variational Learning framework, but only in the special case where two, and not more, grammatical variants compete. Introducing the notion of an advantage matrix, I generalize Variational Learn-ing to situations where the learner receives input generated by more than two grammars, and show that diachronically stable variation is an intrinsic feature of several types of such multiple-grammar systems. This invites experimentalists to take the possibility of stable variation seriously and identifies one possible place where to look for it: situations of complex language contact.
Agreement between self-reports, proxy-reports and the National Patient Register regarding diagnoses of cardiovascular disorders and diabetes mellitus in a population-based sample of 80-year-olds
Authors: Rydén Lina , Sigström Robert , Nilsson Johan , Sundh Valter , Falk Erhag Hanna , Kern Silke , Waern Margda , Östling Svante , Wilhelmson Katarina , Skoog Ingmar 
Published: March 2019

AbstractBackgroundcognitive impairment is common among older adults, necessitating the use of collateral sources in epidemiological studies involving this age group. The objective of this study was to evaluate agreement between self- and proxy-reports of cardiovascular disorders and diabetes mellitus in a population-based sample of 80-year-olds. Further, both self- and proxy-reports were compared with hospital register data.Methodsdata were obtained from the Gothenburg H70 Birth Cohort Studies in Sweden. The study had a cross-sectional design and information was collected through semi-structured interviews in 2009–2012 from participants born in 1930 (N = 419) and their proxy informants. The National Patient Register provided diagnoses registered during hospital stays. Agreement was measured with Kappa values (K).Resultsagreement between self- and proxy-reports was substantial for diabetes mellitus (K = 0.79), atrial fibrillation (K = 0.61), myocardial infarction (K = 0.75), angina pectoris (K = 0.73) and hypertension (K = 0.62), and fair for intermittent claudication (K = 0.38) and heart failure (K = 0.40). Compared to the National Patient Register, a large proportion of those with a hospital discharge diagnosis were also self- and proxy-reported.Conclusionsproxy informants can be an important source of information, at least for well-defined conditions such as myocardial infarction, angina pectoris and diabetes mellitus.
An Unpaid Debt to Society: How ‘Punishment Debt’ Affects Reintegration and Desistance From Crime in Norway
Authors: Todd-Kvam John 
Published: March 2019

AbstractThe Scandinavian exceptionalism literature has highlighted the relatively progressive and rehabilitative nature of imprisonment in Norway, with the Norwegian Correctional Services taking the view that those convicted of crimes have paid their debt to society at the end of their sentence. However, other parts of the Norwegian state take a more stringent view, imposing and enforcing significant and persistent debts on offenders. This article, based on official documents and interviews with Norwegian desisters and probation caseworkers, analyses how living with debt poses a major challenge for reintegration and desistance. Referred to informally as ‘punishment debt’, this pervasive but less visible aspect of Norwegian penality demonstrates the need to broaden the penal exceptionalism research agenda beyond the confines of the prison.
Screen, Ration and Churn: Demand Management and the Crisis in Children’s Social Care
Authors: Hood Rick , Goldacre Allie , Gorin Sarah , Bywaters Paul 
Published: March 2019

Abstract
This article presents findings from a quantitative study of the national data-sets for statutory children’s social care services in England. The aim of the study was to examine how demand management varied in local authorities with differing levels of area deprivation. About 152 local authorities census returns and other statistical indicators covering the period 2014–2017 were combined into a single data-set. Statistical analysis was undertaken to explore trends over time and correlations between indicators that might indicate patterns in the way demand was managed. Findings showed that high levels of deprivation have continued to be strongly linked to high levels of activity and that local authorities have continued to increase their use of protective interventions relative to referrals. Evidence was found for three interconnected mechanisms, through which local authorities tended to manage demand for services: screening, rationing and workforce churn. The article describes these mechanisms and comments on their significance for the current crisis of demand in the sector.
Stronger Functional Connectivity in the Default Mode and Salience Networks Is Associated With Youthful Memory in Superaging
Authors: Zhang Jiahe , Andreano Joseph M , Dickerson Bradford C , Touroutoglou Alexandra , Barrett Lisa Feldman 
Published: March 2019

Abstract“Superagers” are older adults who, despite their advanced age, maintain youthful memory. Previous morphometry studies revealed multiple default mode network (DMN) and salience network (SN) regions whose cortical thickness is greater in superagers and correlates with memory performance. In this study, we examined the intrinsic functional connectivity within DMN and SN in 41 young (24.5 ± 3.6 years old) and 40 older adults (66.9 ± 5.5 years old). Superaging was defined as youthful performance on a memory recall task, the California Verbal Learning Test (CVLT). Participants underwent a resting-state functional magnetic resonance imaging (fMRI) scan and performed a separate visual–verbal recognition memory task. As predicted, within both DMN and SN, superagers had stronger connectivity compared with typical older adults and similar connectivity compared with young adults. Superagers also performed similarly to young adults and better than typical older adults on the recognition task, demonstrating youthful episodic memory that generalized across memory tasks. Stronger connectivity within each network independently predicted better performance on both the CVLT and recognition task in older adults. Variation in intrinsic connectivity explained unique variance in memory performance, above and beyond youthful neuroanatomy. These results extend our understanding of the neural basis of superaging as a model of successful aging.
Prognostic impact of lymphovascular invasion in lymph node-negative superficial esophageal squamous cell carcinoma
Authors: Oguma J , Ozawa S , Kazuno A , Yamamoto M , Ninomiya Y , Yatabe K , Makuuchi H , Ogura G 
Published: March 2019

SUMMARY
The relationship between lymphovascular invasion (LVI) and prognosis in patients with superficial esophageal squamous cell carcinoma (SESCC) is unclear. The aim of this study is to evaluate prognostic factors in patients with lymph node-negative SESCC. A total of 195 patients with pathologically confirmed T1a-MM, T1b, and lymph node-negative SESCC were retrospectively reviewed in this study. Overall, the disease-free survival (DFS) rate was poorer in the lymphatic invasion-positive group than in the lymphatic invasion-negative group (p = 0.002) and a multivariate analysis suggested that lymphatic invasion was the only independent prognostic factor of DFS in patients with lymph node-negative SESCC (HR = 4.075, p = 0.005). Distant organ recurrence occurred in one patient (1/52, 1.9%) in the T1b-SM2 group and in six patients (6/61, 9.7%) in the T1b-SM3 group; all of these patients had LVI. LVI-positive patients had a poorer DFS than invasion-negative patients in the T1b-SM2 and SM3 groups (p = 0.026), and a multivariate analysis suggested that LVI was the only independent prognostic factor of DFS in patients with lymph node-negative SM2 and SM3 SESCC (HR = 5.165, p = 0.031). Lymph node-positive patients had a significantly poorer DFS rate than lymph node negative and LVI positive patients among the SM2 and SM3 SESCC patients (p = 0.018). The present results suggested that LVI was an independent prognostic factor in patients with SM2 and SM3 lymph node-negative SESCC; however their prognosis was not worse than that of patients with lymph node-positive SM2 and SM3 SESCC, for whom adjuvant therapy is indicated as a standard treatment.
Heparin dosing in uninterrupted anticoagulation with dabigatran vs. warfarin in atrial fibrillation ablation: RE-CIRCUIT study
Authors: Calkins Hugh , Willems Stephan , Verma Atul , Schilling Richard , Hohnloser Stefan H , Okumura Ken , Nordaby Matias , Kleine Eva , Bis Branislav , Gerstenfeld Edward P 
Published: March 2019

Abstract

Aims
To describe heparin dosing requirements in patients who underwent catheter ablation of atrial fibrillation with uninterrupted anticoagulation using dabigatran etexilate (dabigatran) or warfarin to attain therapeutic activated clotting time (ACT) in the RE-CIRCUIT® study. The RE-CIRCUIT study showed significantly fewer major bleeding events in the dabigatran vs. warfarin treatment group. Unfractionated heparin was administered during the procedure to maintain ACT >300 s.

Methods and results
Patients were randomly assigned to dabigatran 150 mg bid or international normalized ratio-adjusted warfarin. Ablation was performed with uninterrupted anticoagulation and continued for 8 weeks after the procedure. Heparin was administered after placement of femoral sheaths before or immediately after transseptal puncture. Ablation was performed in 635 patients (dabigatran, 317; warfarin, 318); data were available from 396 patients administered heparin (dabigatran, 191; warfarin, 205). Most frequent time window from last dose of study drug to septal puncture was 0 to <4 h in the dabigatran (41.3%) and 16 to <24 h in the warfarin arms (44.7%). Overall mean (standard deviation) heparin dose was similar between the dabigatran and warfarin groups [12 402 (10 721) vs. 11 910 (8359) IU, respectively]. Heparin dosing requirement to reach therapeutic ACT was lowest when time from last dose of dabigatran to septal puncture was 0 to <4 h.

Conclusion
Patients treated with dabigatran required a similar amount of unfractionated heparin as those treated with warfarin to achieve an ACT of >300 s during ablation. More heparin units were required when the time from the last dose of dabigatran to septal puncture increased.
Socioeconomic Status and Parenting Style From Childhood: Long-Term Effects on Cognitive Function in Middle and Later Adulthood
Authors: Liu Yujun , Lachman Margie E 
Published: March 2019

Abstract

Objectives
This study assesses whether childhood socioeconomic status (SES) is related to cognitive function and cognitive change at mid and later life and explores the buffering effects of parenting style and adulthood SES.

Method
Data were derived from the 3 waves of the Midlife in the United States (MIDUS) study, a national survey including 7,108 participants aged from 24 to 75 years at baseline. We used multiple regression and multilevel models to investigate the associations between childhood SES, adulthood SES, and cognitive performance and change at midlife and the role of parents’ affection and discipline.

Results
Low childhood SES was associated with lower cognitive function and more cognitive decline at mid and later life. Adulthood SES moderated the effect of childhood SES on cognitive function. Interactions showed that paternal discipline was positively related to cognitive function among participants with low childhood SES, and negatively related to cognitive function among participants with high childhood SES. High paternal affection was associated with less cognitive decline at mid and later life.

Discussion
The findings advance the understanding of the long-term consequences of SES and psychosocial factors in early life that can lead to optimal cognitive function in middle and old age.
Effect of light-emitting diodes (LEDs) on snow crab catch rates in the Barents Sea pot fishery
Authors: Nguyen Khanh Q , Humborstad Odd-Børre , Løkkeborg Svein , Winger Paul D , Bayse Shannon M 
Published: March 2019

Abstract
Snow crab (Chionoecetes opilio) has become an important species for the Norwegian seafood industry since its first commercial harvest in 2012. However, periodically catch rates can be low, causing a financial strain on the fishery. Thus, improving the catch rate of existing pot designs has the potential to significantly improve the profitability of fishing enterprises. In this study, we investigated whether the addition of low-powered purple and white light-emitting diode (LED) fishing lights inside the pots could improve catch rates of snow crab in the Barents Sea. Results showed that pots with purple lights harvested a 12.8% higher catch per unit effort (CPUE; number of crab per pot) of legal-sized crab, which was significantly more than the control pots (p = 0.035); pots with white lights did not catch significantly more crab (p &gt; 0.05). Pots equipped with only light (no bait) caught very few crabs and were not considered a viable alternative. Although purple LEDs increased snow crab capture, the economic benefits of using underwater lights in pots remains unclear given the high capital investment required.
The Loewner Energy of Loops and Regularity of Driving Functions
Authors: Rohde Steffen , Wang Yilin 
Published: March 2019

Abstract
Loewner driving functions encode simple curves in 2D simply connected domains by real-valued functions. We prove that the Loewner driving function of a $C^{1,\beta }$ curve (differentiable parametrization with $\beta$-Hölder continuous derivative) is in the class $C^{1,\beta -1/2}$ if $1/2&lt;\beta \leq 1$, and in the class $C^{0,\beta + 1/2}$ if $0 \leq \beta \leq 1/2$. This is the converse of a result of Carto Wong [26] and is optimal. We also introduce the Loewner energy of a rooted planar loop and use our regularity result to show the independence of this energy from the basepoint.
Autoimmunity and immunological tolerance in autoimmune bullous diseases
Authors: Takahashi Hayato , Iriki Hisato , Mukai Miho , Kamata Aki , Nomura Hisashi , Yamagami Jun , Amagai Masayuki 
Published: March 2019

Abstract
Autoimmune diseases are devastating conditions in which the immune system is directed against the host, leading to life-threatening destruction of organs. Although autoantigens are ill-defined in most autoimmune diseases, this is not the case in the skin. Autoimmune bullous diseases have been extensively studied with detailed characterization of autoantigens, the epitopes that are targeted, and the mechanisms of action that mediate autoimmune tissue destruction. Pemphigus is an autoimmune bullous disease caused by circulating IgG that targets two desmosomal proteins, desmoglein 1 and 3, which are crucial for cell–cell adhesion of keratinocytes. Binding of auto-antibodies to desmogleins impairs keratinocyte adhesion, leading to severe blistering disease. Mouse models that recapitulate the human disease have been instrumental in elucidating the detailed pathophysiology. Taking advantage of the fact that desmogleins are specifically targeted in pemphigus, studying humoral and cellular autoimmunity against these autoantigens provides us with an opportunity to understand not only the effector mechanisms of B and T cells in mediating pathology but also how autoreactive lymphocytes are regulated during development in the thymus and post-development in the periphery. This review introduces pemphigus and its subtypes as prototypic autoimmune diseases from which recent basic and translational developments should provide insight into how autoimmunity develops.