bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral nerve injury and myelination: Potential therapeutic strategies
Authors: Modrak Max , Talukder M. A. Hassan , Gurgenashvili Khatuna , Noble Mark , Elfar John C. 
Published: October 2019

AbstractTraumatic peripheral nerve injury represents a major clinical and public health problem that often leads to significant functional impairment and permanent disability. Despite modern diagnostic procedures and advanced microsurgical techniques, functional recovery after peripheral nerve repair is often unsatisfactory. Therefore, there is an unmet need for new therapeutic or adjunctive strategies to promote the functional recovery in nerve injury patients. In contrast to the central nervous system, Schwann cells in the peripheral nervous system play a pivotal role in several aspects of nerve repair such as degeneration, remyelination, and axonal growth. Several non‐surgical approaches, including pharmacological, electrical, cell‐based, and laser therapies, have been employed to promote myelination and enhance functional recovery after peripheral nerve injury. This review will succinctly discuss the potential therapeutic strategies in the context of myelination following peripheral neurotrauma.
Quadriceps Muscle Size Following ACL Injury and Reconstruction: A Systematic Review
Authors: Birchmeier Thomas , Lisee Caroline , Kane Kevin , Brazier Brett , Triplett Ashley , Kuenze Christopher 
Published: October 2019

ABSTRACTImage‐based assessments of quadriceps muscle size facilitate examination of structural changes after anterior cruciate ligament (ACL) injury and reconstruction (ACLR). Understanding the effects of ACLR on muscle size measures may aid in clarifying the contribution of quadriceps atrophy toward quadriceps strength. The purpose of this study was to systematically review the literature examining the effects of ACLR on quadriceps muscle volume and cross‐sectional area (CSA). An online database search was conducted using Web of Science, SportDISCUS, PubMed (Medline), CINHAL (EBSCO), and Cochrane Library limited to articles published after January 1, 1980. Means and standard deviations were extracted for the ACLR limb and the contralateral limb, and sample characteristics from relevant articles. Magnitude of between limb differences were assessed using pooled effect sizes (Hedge's g) and 95% confidence intervals. Eleven articles (five CSA, six muscle volume) were included in this systematic review. Included studies reported negative effective sizes, indicating that the ACLR limb was smaller in CSA or muscle volume compared with the contralateral limb; however, 36% of the included articles reported meaningful difference between the limbs. Quadriceps atrophy may occur following ACL injury and persist after rehabilitation, however, the magnitude of these reductions may not be clinically meaningful and may only partially explain the persistent quadriceps weakness that is ubiquitous among this patient population. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:598–608, 2020
Effects of Sprifermin, IGF1, IGF2, BMP7, or CNP on Bovine Chondrocytes in Monolayer and 3D Culture
Authors: Müller Sylvia , Lindemann Sven , Gigout Anne 
Published: October 2019

ABSTRACTOne possible approach to treat osteoarthritis (OA) is to counteract cartilage degeneration with anabolic compounds that stimulate chondrocyte proliferation and/or extracellular matrix (ECM) production. Several molecules including sprifermin (recombinant human fibroblast growth factor [FGF18]), insulin‐like growth factor‐1 [IGF1] and ‐2 [IGF2], C‐type natriuretic peptide [CNP], and bone metamorphic protein 7 [BMP7] have been shown to have these characteristics both in vitro and in vivo. However, it is not known how these molecules compare each other regarding their effect on phenotype and stimulation of ECM production in primary chondrocytes. The effects of sprifermin, IGF1, IGF2, CNP, and BMP7 were evaluated on bovine articular chondrocytes, first in monolayer to determine their effective concentrations, and then in three‐dimensional (3D) culture at concentrations of 100 ng/ml for sprifermin; 300 ng/ml for IGF1, IGF2, and BMP7; and 10 nM for CNP. In 3D culture, the effects of a permanent exposure or a cyclic exposure consisting of 24 h incubation per week with the compounds were evaluated. All growth factors increased ECM production and cell proliferation to a similar extent but CNP had almost no effect on bovine chondrocytes. Sprifermin was more effective with cyclic exposure, IGF1, and IGF2 with permanent exposure, and BMP7 showed similar results with both exposures. Regarding the cell phenotype, sprifermin appeared to be the only compound favoring the chondrocyte phenotype; it decreased type I collagen expression and had no hypertrophic effect. Together, these results confirmed that sprifermin is a promising disease‐modifying OA drug. © 2019 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 38:653–662, 2020
BMSCs‐Derived Exosomes Ameliorate Pain Via Abrogation of Aberrant Nerve Invasion in Subchondral Bone in Lumbar Facet Joint Osteoarthritis
Authors: Li Jinsong , Ding Zhiyu , Li Yuezhan , Wang Weiguo , Wang Jianlong , Yu Haiyang , Liu Ansong , Miao Jinglei , Chen Shijie , Wu Tianding , Cao Yong 
Published: October 2019

ABSTRACTLumbar facet joint osteoarthritis (LFJ OA) is regarded as one of the common causes of low back pain (LBP). The pathogenesis and underlying mechanism of this disease are largely unknown, there is still no effective disease‐modifying therapy. This study aims to investigate the efficacy of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) on the pathogenesis and behavioral signs of LBP in the LFJ OA mouse model. The pathogenetic change in cartilage and aberrant nerve invasion in the subchondral bone of LFJ in a mouse model after treatment with BMSC‐exosomes was evaluated. BMSC‐exosomes could relieve pain via abrogation of aberrant CGRP‐positive nerve and abnormal H‐type vessel formation in the subchondral bone of LFJ. Moreover, BMSC‐exosomes attenuated cartilage degeneration and inhibited tartrate‐resistant acid phosphatase expression and RANKL‐RANK‐TRAF6 signaling activation to facilitate subchondral bone remodeling. These results indicated that BMSC‐exosomes could relive behavioral signs of LBP and pathological processes in LFJ OA. BMSC‐exosomes have a prominent protective effect and might be a potential therapeutic option for the treatment of LFJ OA causing LBP. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:670–679, 2020
Low‐Dielectric Constant and Low‐Temperature Curable Polyimide/POSS Nanocomposites
Authors: Huang Chao , Li Jinhui , Xie Guangxia , Han Fei , Huang Dongxu , Zhang Fan , Zhang Bo , Zhang Guoping , Sun Rong , Wong Ching‐Ping 
Published: October 2019

AbstractWith the rapid development of ultra large scale integrated circuits, low stress, low thermal expansion, low dielectric constant, and low temperature curable (<250 °C) polyimides (PIs) with excellent mechanical, thermal properties are required. Unfortunately, high curing temperatures above 300 °C and limited dielectric property still remain to be solved. Herein, a new type of aminopropyl isobutyl polysilsesquioxane (POSS) with single vertex activity is introduced by in situ polymerization resulting in the PI‐POSS nanocomposites which exhibit a low dielectric constant (κ ≤ 2.6). Furthermore, low‐temperature curing at 200 °C (99.4% imidization) under the catalysis of quinoline is also achieved. The as‐prepared PI‐POSS nanocomposites also show excellent mechanical properties of which the tensile strength can reach up to 148 MPa and the elongation at break achieves 98%. Moreover, the temperature of weight loss 5% is as high as 550 °C and the glass transition temperature can also reach 349 °C. The as‐prepared PI‐POSS nanocomposites prove excellent electrical performance and mechanical properties, showing a huge market prospect of 5G chip packaging and millimeter wave antenna in the future.
Diversity of small molecule HIV‐1 latency reversing agents identified in low‐ and high‐throughput small molecule screens
Authors: Hashemi Pargol , Sadowski Ivan 
Published: October 2019

AbstractThe latency phenomenon produced by human immunodeficiency virus (HIV‐1) prevents viral clearance by current therapies, and consequently development of a cure for HIV‐1 disease represents a formidable challenge. Research over the past decade has resulted in identification of small molecules that are capable of exposing HIV‐1 latent reservoirs, by reactivation of viral transcription, which is intended to render these infected cells sensitive to elimination by immune defense recognition or apoptosis. Molecules with this capability, known as latency‐reversing agents (LRAs) could lead to realization of proposed HIV‐1 cure strategies collectively termed “shock and kill,” which are intended to eliminate the latently infected population by forced reactivation of virus replication in combination with additional interventions that enhance killing by the immune system or virus‐mediated apoptosis. Here, we review efforts to discover novel LRAs via low‐ and high‐throughput small molecule screens, and summarize characteristics and biochemical properties of chemical structures with this activity. We expect this analysis will provide insight toward further research into optimized designs for new classes of more potent LRAs.
Dynamics of a Majorana Trijunction in a Microwave Cavity
Authors: Trif Mircea , Simon Pascal 
Published: October 2019

AbstractA trijunction made of three topological semiconducting wires, each supporting a Majorana bound state (MBS) at its two extremities, appears as one of the simplest geometries in order to perform braiding of Majorana fermions. Embedding the trijunction into a microwave cavity allows to study the intricate dynamics of the low‐energy MBSs coupled to the cavity electric field under a braiding operation. Extending a previous work [Phys. Rev. Lett. 2019, 122, 236803], the full time evolution of the density matrix of the low‐energy states, including various relaxation channels, is computed both in the adiabatic regime, as well as within the Floquet formalism in the case of periodic driving. It turns out that in the stationary state the observables of the system depend on both the parity of the ground state and on the non‐Abelian Berry phase acquired during braiding. The average photon number and the second‐order photon coherence function g(2)(0) are explicitly evaluated and reveal the accumulated non‐Abelian Berry phase during the braiding process.
Van der Waals Integration of Bismuth Quantum Dots–Decorated Tellurium Nanotubes (Te@Bi) Heterojunctions and Plasma‐Enhanced Optoelectronic Applications
Authors: Zhang Ye , Zhang Feng , Wu Leiming , Zhang Yupeng , Huang Weichun , Tang Yanfeng , Hu Lanping , Huang Pu , Zhang Xiuwen , Zhang Han 
Published: October 2019

AbstractVan der Waals (vdW)‐integrated heterojunctions have been widely investigated in optoelectronics due to their superior photoelectric conversion capability. In this work, 0D bismuth quantum dots (Bi QDs)‐decorated 1D tellurium nanotubes (Te NTs) vdW heterojunctions (Te@Bi vdWHs) are constructed by a facile bottom‐up assembly process. Transient absorption spectroscopy suggests that Te@Bi vdWH is a promising candidate for new‐generation optoelectronic devices with fast response properties. The subsequent experiments and density functional theory calculations demonstrate the vdW interaction between Te NTs and Bi QDs, as well as the enhanced optoelectronic characteristics owing to the plasma effects at the interface between Te NTs and Bi QDs. Moreover, Te@Bi vdWHs‐based photodetectors show significantly improved photoresponse behavior in the ultraviolet region compared to pristine Te NTs or Bi QDs‐based photodetectors. The proposed integration of vdWHs is expected to pave the way for constructing new nanoscale heterodevices.
Assessment of hematologic and corticosterone response in free‐living eastern box turtles (Terrapene carolina carolina) at capture and after handling
Authors: Boers Kayla L. , Allender Matthew C. , Novak Lauren J. , Palmer Jamie , Adamovicz Laura , Deem Sharon L. 
Published: October 2019

AbstractHematology is a common tool for wildlife health assessments. Manual leukocyte counts are required in reptiles, however, disagreement between quantification methods has been observed in some chelonians. This study determined agreement between two methods of leukocyte quantification, eosinophilic leukopet, and blood film white blood cell (WBC) estimates, in free‐living eastern box turtles (Terrapene carolina carolina). Simultaneously, we assessed the impact of handling duration on both leukocyte quantity and corticosterone levels. We collected blood at capture (<2 min from disturbance) and again before release 30–150 min later from 92 box turtles at six sites in Illinois and Tennessee. Constant and proportional error was present in the leukopet results for WBC, lymphocytes, and basophils compared to the estimate method. Both methods were in agreement for heterophils, monocytes, and eosinophils. Agreement between the methods was significantly more likely at WBC counts below 23,241/µl. All hematologic parameters were significantly higher at the final blood draw compared to the initial blood draw using both WBC determination methods, except relative eosinophil and basophil counts. Corticosterone levels varied with time, with maximum concentrations reached at 54 min postcapture, followed by a rapid return to baseline levels. Corticosterone level was not significantly associated with any hematologic parameter or sex. This study provides a framework for understanding the effects of animal handling methodology and diagnostic modality when evaluating hematologic health in box turtles.
Dimensional regularization for holographic RG flows
Authors: Bzowski Adam , Schillo Marjorie 
Published: October 2019

AbstractIn this work, we present a holographic renormalization scheme for asymptotically anti-de Sitter spacetimes in which the dual renormalization scheme of the boundary field theory is dimensional regularization. This constitutes a new level of precision in the holographic dictionary and paves the way for the exact matching of scheme dependent quantities, such as holographic beta functions, with field theory computations. Furthermore, the renormalization procedure identifies a local source field which satisfies the equations of motion along renormalization group flows, resolving a long-standing puzzle regarding the Wilsonian coupling in holography. This identification of the source field also provides new insight into field theories deformed by marginal operators, which have been traditionally difficult to analyze due to altered bulk asymptotics. Finally, we demonstrate a new relation equating the analyticity of the holographic beta function to the absence of conformal anomalies, and conjecture that the conformal anomaly should vanish in the UV for all holographic constructions.
Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease
Authors: Verhagen Johan , Yusuf Norkhairin , Smith Emma L. , Whettlock Emily M. , Naran Kerina , Arif Sefina , Peakman Mark 
Published: October 2019

Abstract

Aims/hypothesis
The molecular basis for the pathological impact of specific HLA molecules on autoimmune diseases such as type 1 diabetes remains unclear. Recent natural history studies in children have indicated a link between specific HLA genotypes and the first antigenic target against which immune responses develop. We set out to examine this link in vivo by exploring the diabetogenicity of islet antigens on the background of a common diabetes-associated HLA haplotype.

Methods
We generated a novel HLA-transgenic mouse model that expresses high-risk genes for type 1 diabetes (DRB1*03:01-DQA1*05:01-DQB1*02:01) as well as human CD80 under the rat insulin promoter and human CD4, on a C57BL/6 background. Adjuvanted antigen priming was used to reveal the diabetogenicity of candidate antigens and peptides.

Results
HLA-DR3-DQ2+huCD4+IA/IE−/−RIP.B7.1+ mice spontaneously developed autoimmune diabetes (incidence 46% by 35 weeks of age), accompanied by numerous hallmarks of human type 1 diabetes (autoantibodies against GAD65 and proinsulin; pancreatic islet infiltration by CD4+, CD8+ B220+, CD11b+ and CD11c+ immune cells). Disease was markedly accelerated and had deeper penetrance after adjuvanted antigen priming with proinsulin (mean onset 11 weeks and incidence 100% by 20 weeks post challenge). Moreover, the diabetogenic effect of proinsulin located to the 15-residue B29-C11 region.

Conclusions/interpretation
Our study identifies a proinsulin-derived peptide region that is highly diabetogenic on the HLA-DR3-DQ2 background using an in vivo model. This approach and the peptide region identified may have wider implications for future studies of human type 1 diabetes.
Response surface methodology for the optimization of acid dye adsorption onto activated carbon prepared from wild date stones
Authors: Brahmi Lamia , Kaouah Farida , Boumaza Salim , Trari Mohamed 
Published: October 2019

AbstractIn the present study,wild date stones(WDS) were used as a novel and sustainable precursor for high-quality activated carbon preparation to be applied for the removal of Acid Blue 25 dye (AB25) from synthetic water. The carbonization temperature of the raw material was selected at 850 °C on the basis of thermo-gravimetric analysis. The adsorbents were characterized by the BET method, Fourier transform infrared spectroscopy, and scanning electron microscopy. The results indicated that the activated carbon presents a high specific surface area (610.84 m2 g−1) and a pore volume (0.224 cm3 g−1) compared with the natural material. Based on the central composite design, the effect of different parameters such as the biomass dose, initial dye concentration, contact time and temperature was optimized and the optimal removal of AB25 (99.61%) was achieved for AB25 concentration of 100 mg L−1and an adsorbent dose of 0.8 g L−1, at 45 °C after 120 min. The kinetic studies indicated that the pseudo-second-order model was appropriately applied for the adsorption kinetic of AB25 onto wild date stones activated carbon. The intraparticle diffusion model is not the only controlling step, and other mechanisms may be involved in the adsorption process. The Langmuir isotherm provided the best fit with a high correlation coefficient (R2) of 0.993 and a maximum monolayer adsorption capacity of 181.59 mg g−1.
Comparison of the experimental results with the Langmuir and Freundlich models for copper removal on limestone adsorbent
Authors: Khayyun Thair Sharif , Mseer Ayad Hameed 
Published: October 2019

Abstract
The purpose of this study was to investigate the possibility of the limestone as an adsorbed media and low-cost adsorbent. Batch adsorption studies were conducted to examine the effects of the parameters such as initial metal ion concentration C0, particle size of limestone DL, adsorbent dosage and equilibrium concentration of heavy metal Ce on the removal of the heavy metal (Cu) from synthetic water solution by limestone. The removal efficiency is increased with the increase in the volume of limestone (influenced by the media specific area). It has been noted that the limestone with diameter of 3.75 is the most effective size for removal of copper from synthetic solution. The adsorption data were analyzed by the Langmuir and Freundlich isotherm model. The average values of the empirical constant and adsorption constant (saturation coefficient) for the Langmuir equation were a = 0.022 mg/g and b = 1.46 l/mg, respectively. The average values of the Freundlich adsorption constant and empirical coefficient were Kf = 0.010 mg/g and n = 1.58 l/mg, respectively. It was observed that the Freundlich isotherm model described the adsorption process with high coefficient of determination R2, better than the Langmuir isotherm model and for low initial concentration of heavy metal. Also, when the values of amount of heavy metal removal from solution are predicted by the Freundlich isotherm model, it showed best fits the batch study. It is clear from the results that heavy metal (Cu) removal with the limestone adsorbent appears to be technically feasible and with high efficiency.
The Proof Is in the Process: Self-Reporting Under International Human Rights Treaties
Authors: Creamer Cosette D. , Simmons Beth A. 
Published: October 2019

AbstractRecent research has shown that state reporting to human rights monitoring bodies is associated with improvements in rights practices, calling into question earlier claims that self-reporting is inconsequential. Yet little work has been done to explore the theoretical mechanisms that plausibly account for this association. This Article systematically documents—across treaties, countries, and years—four mechanisms through which reporting can contribute to human rights improvements: elite socialization, learning and capacity building, domestic mobilization, and law development. These mechanisms have implications for the future of human rights treaty monitoring.
Vestibular Exercises as a Fall Prevention Strategy in Patients with Cognitive Impairment
Authors: Varriano Brenda , Sulway Shaleen , Wetmore Curtis , Dillon Wanda , Misquitta Karen , Multani Namita , Anor Cassandra , Martinez Maria , Cacchione Elena , Rutka John , Tartaglia Maria Carmela 
Published: October 2019

ABSTRACT:Vestibular impairment (VI) and cognitive impairment (CI) are risk factors for senior falls. We tested the feasibility of a self-directed 12-week vestibular rehabilitation (VR) program in Memory Clinic patients (65 years+) with a fall, CI and VI. We assessed recruitment, exercise adherence and ability to complete questionnaires/assessments. Twelve patients with CI and falls were screened and 8/12 (75% – prevalence) had VI. All patients completed the screening tests/questionnaires (100% – completeness); 7/8 patients were recruited (87.5% – recruitment); 1/7 (85.7% – attrition) patient attended follow-up. VI is prevalent in patients with CI experiencing falls but traditional VR is not feasible, so a novel delivery of VR must be explored.
Persistent Patterns in the U.S. Alcohol Market: Looking at the Link between Demographics and Drinking
Authors: Hart Jarrett , Alston Julian M. 
Published: October 2019

AbstractGlobal consumption patterns for alcoholic beverages are evolving, with some convergence in per capita consumption among nations, as traditionally beer-drinking nations increase their consumption of wine and, conversely, wine-consuming nations shift towards beer. In a forthcoming article (Hart and Alston, 2019), we explore regional patterns of alcoholic beverage consumption within the United States. One purpose is to see if similar patterns of spatial convergence in consumption patterns can be observed within countries as have been documented in international comparisons. A more fundamental purpose is to explore the converse question and seek to better understand the persistent differences in alcoholic beverage consumption among groups. These issues are addressed using annual U.S. national and state-level data over four decades and, for the more recent period, supermarket scanner data at finer scales of geopolitical aggregation. This proceedings article focuses on the analysis using supermarket scanner data. We find that socioeconomic and demographic variables appear to play significant roles in accounting for the spatial differences in consumption patterns. (JEL Classifications: D12, L66)