bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolution of Retinal Bleeding And Exudative Retinal Detachment After Chemotherapy with Melphalan In Multiple Myeloma
Authors: Andayani Ari , Budhiastra I Putu , Adnyana I Wayan Losen , Wijayati Made Paramita 
Published: May 2019

Introduction: Multiple myeloma is the second most common hematologic cancer. It is characterized by the clonal proliferation of malignant plasma cells and associated organ dysfunction. Ophthalmic manifestations include hyperviscosity retinopathy and retinal detachment. The aim of this study is to report retinal manifestation in Multiple Myeloma.
Methods: A man 45 years old, complained loss of vision on both eyes especially left eye over 1 month. He also feels weakness and 3 times spontaneous nose bleeding. His visual acquity is 6/12 on the right and 2/60 left eye with Retinal Bleeding and Retinal Detachment. His Laboratory examination result increase in WBC 65.91 x 103/µL (Neutrophil, Monocyte, Basophil and Lymphocyte) decrease RBC 3 x 106/µL, HGB 6.85 g/dL, normal PLT 193.60 103/µL, Normal Bleeding and Clotting Time and increase ESR 140 mm/hour. Multiple myeloma was diagnosed by Internal Department with bone marrow biopsy and increase of Gamma Globulin.
Results: The patient was treated with melphalan 3 tablet 2 times a day and prednisone 4 mg 3 times a day for 5 days every 28 days. After 8 month the VA 6/6 on the right and 6/10 on the left with complete resolution of on the right eye and there are resolution on the left eye with fibrosis, the laboratory examination normal WBC 3.8 x 103/µL with Neutrophil 59.3%, Monocyte 6.1 %, Eosinophil 6.3 %, Basophil 0.3 % and Lymphocyte 28.0 %, normal RBC 4.6 x 106/µL, slightly decrease HGB 12.8 g/dL, normal PLT 177.0 x 103/µL and decrease Gamma Globulin.
Discussion: This case of bilateral Retinal Bleeding and Exudative Retinal Detachment are remarkable for both its presentation and response to melphalan therapy. Treatment with melphalan and prednison alone was sufﬁcient to clear the Retinal Bleeding and restoration of Exudative Retinal Detachment.
Conclusion: Complication of Multiple Myeloma can caused organ disfunction such as retinal bleeding and exudative retinal detachment. Early Diagnosis is very crucial. In our case combination cemotheraphy with Melphalan and Prednison showed clinically significant resolution. Workship Internal Department and Ophthalmology Department are very important for management and monitoring ophthalmology manifestation in multiple myeloma.
The COS Absorption Survey of Baryon Harbors (CASBaH): Warm–Hot Circumgalactic Gas Reservoirs Traced by Ne viii Absorption
Authors: Burchett Joseph N. , Tripp Todd M. , Prochaska J. Xavier , Werk Jessica K. , Tumlinson Jason , Howk J. Christopher , Willmer Christopher N. A. , Lehner Nicolas , Meiring Joseph D. , Bowen David V. , Bordoloi Rongmon , Peeples Molly S. , Jenkins Edward B. , O’Meara John M. , Tejos Nicolas , Katz Neal 
Published: May 2019

Abstract
We survey the highly ionized circumgalactic media (CGM) of 29 blindly selected galaxies at

based on high signal-to-noise ratio ultraviolet spectra of z ≳ 1 quasi-stellar objects and the galaxy database from the COS Absorption Survey of Baryon Harbors (CASBaH). We detect the Ne viii doublet in nine of the galaxies, and for gas with N(

)

(

), we derive a

covering fraction

(

) within impact parameters ρ ≤ 200 kpc of M
* = 109.5–11.5
M
⊙ galaxies and

(

) within ρ ≤ 1.5 virial radii. We estimate the mass in

-traced gas to be

, or 6%–20% of the expected baryonic mass if the

absorbers have solar metallicity. Ionizing Ne vii to

requires 207 eV, and photons with this energy are scarce in the CGM. However, for the median halo mass and redshift of our sample, the virial temperature is close to the peak temperature for the

ion, and the

-bearing gas is plausibly collisionally ionized near this temperature. Moreover, we find that photoionized

requires cool and low-density clouds that would be highly underpressured (by approximately two orders of magnitude) relative to the putative, ambient virialized medium, complicating scenarios where such clouds could survive. Thus, more complex (e.g., nonequilibrium) models may be required; this first statistical sample of

absorber/galaxy systems will provide stringent constraints for future CGM studies.
A Sample of Low-energy Bursts from FRB 121102
Authors: Gourdji K. , Michilli D. , Spitler L. G. , Hessels J. W. T. , Seymour A. , Cordes J. M , Chatterjee S. 
Published: May 2019

Abstract
We present 41 bursts from the first repeating fast radio burst (FRB) discovered (FRB 121102). A deep search has allowed us to probe unprecedentedly low burst energies during two consecutive observations (separated by one day) using the Arecibo telescope at 1.4 GHz. The bursts are generally detected in less than one-third of the 580 MHz observing bandwidth, demonstrating that narrowband FRB signals may be more common than previously thought. We show that the bursts are likely faint versions of previously reported multi-component bursts. There is a striking lack of bursts detected below 1.35 GHz and simultaneous Very Large Array observations at 3 GHz did not detect any of the 41 bursts, but did detect one that was not seen with Arecibo, suggesting preferred radio emission frequencies that vary with epoch. A power-law approximation of the cumulative distribution of burst energies yields an index −1.8 ± 0.3, which is much steeper than the previously reported value of ∼−0.7. The discrepancy may be evidence for a more complex energy distribution. We place constraints on the possibility that the associated persistent radio source is generated by the emission of many faint bursts (∼700 ms−1). We do not see a connection between burst fluence and wait time. The distribution of wait times follows a log-normal distribution centered around ∼200 s; however, some bursts have wait times below 1 s and as short as 26 ms, which is consistent with previous reports of a bimodal distribution. We caution against exclusively integrating over the full observing band during FRB searches, because this can lower signal to noise.
À fleur de peau... de qui ?
Authors: Bayot Ingrid 
Published: May 2019

On ne saurait évoquer le nouveau-né sans évoquer la personne humaine qui constitue son premier fournisseur de sensations tactiles et qui, partant, initialise son « Moi-peau ». Avec quelle attention, quelle présence, quelle aisance, élans, hésitations ou réticences pourra-t-elle, à travers les soins et les multiples gestes du maternage, le contenir et le confirmer ? Chacune plonge dans l’aventure maternelle avec tout ce qu’elle est, avec son histoire, son parcours de vie, sa mémoire de peau. Par conséquent, à quelles attentions et précautions sont conviés les soignants ?
USP19 Inhibits TNF-α– and IL-1β–Triggered NF-κB Activation by Deubiquitinating TAK1
Authors: Lei Cao-Qi , Wu Xin , Zhong Xuan , Jiang Lu , Zhong Bo , Shu Hong-Bing 
Published: May 2019

Abstract
The dynamic regulations of ubiquitination and deubiquitination play important roles in TGF-β–activated kinase 1 (TAK1)-mediated NF-κB activation, which regulates various physiological and pathological events. We identified ubiquitin-specific protease (USP)19 as a negative regulator of TNF-α– and IL-1β–triggered NF-κB activation by deubiquitinating TAK1. Overexpression of USP19 but not its enzymatic inactive mutant inhibited TNF-α– and IL-1β–triggered NF-κB activation and transcription of downstream genes, whereas USP19 deficiency had the opposite effects. Usp19−/− mice produced higher levels of inflammatory cytokines and were more susceptible to TNF-α– and IL-1β–triggered septicemia death compared with their wild-type littermates. Mechanistically, USP19 interacted with TAK1 in a TNF-α– or IL-1β–dependent manner and specifically deconjugated K63- and K27-linked polyubiquitin chains from TAK1, leading to the impairment of TAK1 activity and the disruption of the TAK1–TAB2/3 complex. Our findings provide new insights to the complicated molecular mechanisms of the attenuation of the inflammatory response.
Evidence of Trained Immunity in a Fish: Conserved Features in Carp Macrophages
Authors: Petit Jules , Embregts Carmen W. E. , Forlenza Maria , Wiegertjes Geert F. 
Published: May 2019

Abstract
Trained immunity is a form of innate immune memory best described in mice and humans. Clear evidence of the evolutionary conservation of trained immunity in teleost fish is lacking. Given the evolutionary position of teleosts as early vertebrates with a fully developed immune system, we hypothesize that teleost myeloid cells show features of trained immunity common to those observed in mammalian macrophages. These would at least include the ability of fish macrophages to mount heightened responses to a secondary stimulus in a nonspecific manner. We established an in vitro model to study trained immunity in fish by adapting a well-described culture system of head kidney–derived macrophages of common carp. A soluble NOD-specific ligand and a soluble β-glucan were used to train carp macrophages, after which cells were rested for 6 d prior to exposure to a secondary stimulus. Unstimulated trained macrophages displayed evidence of metabolic reprogramming as well as heightened phagocytosis and increased expression of the inflammatory cytokines il6 and tnf-α. Stimulated trained macrophages showed heightened production of reactive oxygen and nitrogen species as compared with the corresponding stimulated but untrained cells. We discuss the value of our findings for future studies on trained immunity in teleost fish.
Inclusiveness matters: The development of ethnopolitics in Malaysia
Authors: Ku Samuel C.Y. , Chiao Yuan-Ming 
Published: May 2019

Malaysian voters made a historical decision in May 2018, ushering in what observers termed a “Malay political tsunami” by displacing the UMNO government’s decades-long rule. This paper argues that the spirit of inclusiveness played a crucial role in the first transition of power in Malaysia. Moreover, the inclusive representation of major ethnic groups in the multi-racial state by the winning Alliance Hope coalition was a key factor leading to the transition. This paper also examines the political development in Malaysia, from the beginning of inclusive politics in the early stage of its independence, to the decline of inclusiveness from the 1970s to 1990s, to the collapse of the inclusive politics since 2008 when the DAP (the Chinese opposition party) produced a major victory over the MCA (the Chinese party in the ruling UMNO government) in the May 2008 elections. Finally, this paper also explores the challenges of the new ruling Alliance Hope in Malaysia.Keywords: Ethno-politics, inclusiveness, UMNO, MCA, MIC, Alliance Hope
Anais do VI ENCONTRO NACIONAL DOS RESIDENTES EM SAÚDE (ENRS)
Authors: Universidade Federal do Paraná UFPR 
Published: May 2019

Os Encontros nacionais das residências multiprofissionais em saúde têm sido reconhecidos como espaços para aproximação e diálogo entre os atores dos segmentos que compõem os Programas (residentes, preceptores, docentes, tutores, coordenadores e gestores), bem como entre trabalhadores da área de saúde, gestores, usuários e instituições. E assim tem mobilizado e propiciado a troca de experiências, discussões, a democratização e participação social por meio de rodas de conversa, grupos de trabalho, apresentações culturais, e a elaboração de um relatório final, entendido como a Carta de Recomendações de cada evento, que leva o nome da localidade que o sedia que contém sugestões para a qualificação dos programas de residências multiprofissionais. E ainda, proporciona a produção e divulgação científica acerca do trabalho em saúde no SUS, e das múltiplas experiências desenvolvidas nos programas em todo o Brasil.As comissões organizadoras em conjunto com o FNRS já realizaram cinco Encontros Nacionais. O I ENRS ocorreu em 2011, no Rio de Janeiro/RJ, e foi parte do Encontro da Rede Unida. O II ENRS, em 2012, foi realizado em Porto Alegre/RS, organizado concomitantemente ao 10° Congresso Brasileiro de Saúde Coletiva, teve como objetivo articular “O Movimento Nacional de Residências em Saúde”, junto aos segmentos de gestores, trabalhadores, residentes, usuários, tutores e preceptores, para a consolidação de uma Política Nacional de Residências em Saúde comprometida com o SUS. O III ENRS foi sediado em Fortaleza/CE, em 2013, e teve como tema “Educação Permanente no Brasil: desafios para as residências em um contexto de precarização e privatização do SUS”. No IV ENRS, realizado em Recife/Pernambuco, em 2014, a educação permanente voltou a ser temática central com o título: “Residências em Saúde como Estratégia de Educação Permanente para o Fortalecimento do SUS”. No V ENRS e último encontro, realizado em 2015, em Florianópolis/SC, trabalhou-se com o tema “O Desafio da interdisciplinaridade e a contribuição da Residência para a (re) afirmação do SUS”.Neste ano, o VI ENRS foi realizado em Curitiba-PR, na Universidade Federal do Paraná, no período de 5 a 8 de julho de 2016 e teve como tema “Residências em Saúde: Construindo Nossa Identidade e Questionando Nossa Formação”, e teve como objetivo resgatar o contexto histórico dos Programas de Residência em Saúde ; discutir seus modelos de atenção multi, inter e transdisciplinar, e a qualidade da formação, com ênfase ao papel das instituições de ensino superior, tutores e preceptores, no programa político pedagógico, bem como, nos modelos de gestão em saúde e processos de trabalho. Comissão OrganizadoraVI Encontro Nacional de Residências em SaúdeCuritiba, julho de 2016.
Unsteady free covection oscillatory couette flow through a porous medium with periodic wall temperature
Authors: Sharma P. Kumar , Sharma B. Kumar , Chaudhary R. C. 
Published: May 2019

This communication investigates the effect of free convection on the heat transfer and the flow through a highly porous medium bounded by two vertical parallel porous plates. It is assume that free stream velocity oscillates
in times about a constant mean. Assuming periodic temperature at the moving plate, the approximate solutions for velocity field, emperature field, skin-friction and the rate of heat transfer are obtained and discussed with the help of graphs and tables.
Detection of a new nontrivial family in the stable homotopy of spheres $ \mbf{\pi_{\ast}S} $
Authors: Xiugui Liu , Yinglong Jin 
Published: May 2019

To determine the stable homotopy groups of spheres is one of the central problems in homotopy theory. Let $ A $ be the mod $ p $ Steenrod algebra and $S$ the sphere spectrum localized at an odd prime $ p $. In this article, it is proved that for $ p\geqslant 7 $, $ n\geqslant 4 $ and $ 3\leqslant s $, $ b_0 h_1 h_n \tilde{\gamma}_{s} \in Ext_A^{s+4,\ast}(\mathbb{Z}_p,\mathbb{Z}_p) $ is a permanent cycle in the Adams spectral sequence and converges to a nontrivial element of order $ p $ in the stable homotopy groups of spheres $ \pi_{p^nq+sp^{2}q+(s+1)pq+(s-2)q-7}S $, where $ q=2(p-1 ) $.
Exploring the links between tourism and quality of institutions
Authors: Buitrago Esquinas Eva Mª , Caraballo Pou Mª Ángeles 
Published: May 2019

This paper introduces a new perspective on the impacts of tourism on host communities by analyzing the links between tourism specialization and quality of institutions. Our research has two principal aims: firstly, to test the significance and sign of this relationship; and secondly, to explore the channels through which tourism could affect institutional quality. To this end, an econometric analysis is conducted using a sample of 92 countries over the period 1995-2014. The results indicate that there is a significant and positive association between tourism specialization and institutional quality. Moreover, this relation can be explained through three main channels: level of income, income inequality, and economic freedom.
Este trabajo aporta una nueva perspectiva sobre los impactos del turismo analizando las relaciones entre la especialización turística de un país y la calidad de sus instituciones. La investigación plantea dos objetivos: (1) testar empíricamente la significatividad y signo de dichas relaciones y (2) explorar los canales a través de los que se producen. Realizamos un análisis econométrico para 92 países y 20 años. Los principales resultados indican la existencia de una asociación significativa y positiva entre turismo y calidad institucional que se produce principalmente a través de tres canales: nivel de renta, distribución de la renta y libertad económica.
La actividad comercial en empresas turísticas. Percepción de los estudiantes de turismo
Authors: Canales Ronda Pedro , Hernández Fernández Asunción 
Published: May 2019

El presente trabajo pretende analizar la opinión que los estudiantes universitarios de Turismo tienen respecto a desarrollar su futuro laboral en el área comercial de empresas turísticas, la que más oferta de puestos de trabajo genera en España. En concreto, se pretende conocer cuál es su percepción sobre este tipo de trabajo, tanto desde un punto de vista personal como profesional. Para alcanzar estos objetivos, se ha encuestado a 348 estudiantes de diferentes cursos, de grado y posgrado, que han sido clasificados en función de su interés por trabajar como vendedores en el sector turístico. Los resultados muestran que, en general, la valoración de una futura actividad de tipo comercial es positiva.
The current research intends to analyze the opinion that the tourism university students have regarding to develop their future labor in the commercial management area of tourist companies, the one that more offer of jobs generates in Spain. Specifically, we want to know what the perception of this type of work is, both from a personal and professional point of view. To achieve these objectives, 348 students, from different undergraduate and postgraduate courses, have been surveyed, who have been classified according to their interest in working as sellers in the tourism sector. The results show that, in general, the valuation of a future commercial activity is positive.
Relevancia y desafíos del paisaje en la formación de una imagen turística de prestigio: la Costa de Llanes (Asturias)
Authors: Sevilla Álvarez Juan , Rodríguez Pérez Carmen 
Published: May 2019

La costa de Llanes (oriente de Asturias), enmarcada por el mar Cantábrico y la media montaña de la Sierra del Cuera (apenas separados por 8 kilómetros), presenta rasgos paisajísticos singulares que han incentivado las visitas turísticas desde hace ya más de un siglo. Se trata de un espacio marcado por la trascendencia de los condicionantes naturales pero transformado en época reciente por la presión turística. En este trabajo se analiza el papel del paisaje en el desarrollo turístico, desde una perspectiva histórica, y se indaga en la capacidad de la propia actividad turística para transformar ese paisaje que, en origen, constituye un factor de atracción esencial. Siguiendo este cometido, se atiende a la evolución histórica de la divulgación del paisaje y se valoran los planteamientos de las acciones institucionales en lo relativo a la ordenación sectorial y territorial integral a distintas escalas.
The coast of Llanes, framed by the Cantabrian Sea and Sierra del Cuera mountains (barely separated by 8 kilometers), contains unique landscape elements that have stimulated tourist visits for more than a century. It is a space marked by the transcendence of natural conditions but transformed in recent times by tourist pressure. This paper analyzes the role of landscape in tourism development, from a historical perspective, and the ability of tourism itself to transform this landscape that, in origin, constitutes an essential factor of attraction. The historical evolution of landscape knowledge dissemination is presented as well as the approaches of institutional actions in sectoral and integral spatial planning at different scales.
Evaluación de la percepción de congestión del turista en el centro histórico de Quito
Authors: Torres Matovelle Pablo , Tapia López Jesús , Suquilanda Agila Karla 
Published: May 2019

La congestión es un fenómeno que preocupa desde hace décadas a los gestores de destinos turísticos. Pocos estudios se han desarrollado para evaluarla en ciudades patrimoniales sobre todo a partir de la percepción del turista, notando un escaso tratamiento del tema en Latinoamérica. Esta investigación evalúa la percepción de congestión del turista en el Centro Histórico de Quito, mediante aportes metodológicos que vinculan variables de tipo motivacional, emocional y conductual. Los resultados indican que la percepción de congestión es percibida mayoritariamente entre leve y moderada.
Crowding is a phenomenon that has worried managers of tourist destinations for decades. Few studies have been developed to evaluate it in heritage cities from the perception of the visitor, noticing a poor treatment of the subject in Latin America. This research evaluates the tourist crowding perception in the Historic Center of Quito, through methodological contributions that link motivational, emotional and behavioral variables. The results indicate that crowding is perceived mostly between mild and moderate.
CAM: An alignment-free method to recover phylogenies using codon aversion motifs
Authors: Miller Justin B , McKinnon Lauren M , Whiting Michael F , Ridge Perry G 
Published: May 2019

Background. Common phylogenomic approaches for recovering phylogenies are often time-consuming and require annotations for orthologous gene relationships that are not always available. In contrast, alignment-free phylogenomic approaches typically use structure and oligomer frequencies to calculate pairwise distances between species. We have developed an algorithm to quickly calculate distances between species based on codon aversion.
Methods. Utilizing a novel alignment-free character state, we present CAM, an alignment-free approach to recover phylogenies by comparing differences in codon aversion motifs (i.e., the set of unused codons within each gene) across all genes within a species. Synonymous codon usage is non-random and differs between organisms, between genes, and even within a single gene, where many genes do not use all possible codons. We report a comprehensive analysis of codon aversion within 229 742 339 genes from 23 428 species across all kingdoms of life, and we provide an alignment-free framework for its use in a phylogenetic construct. For each species, we first construct a set of codon aversion motifs spanning all genes within that species. We define the pairwise distance between two species, A and B, as one minus the number of shared codon aversion motifs divided by the total codon aversion motifs of the species, A or B, containing the fewest motifs. This approach allows us to calculate pairwise distances even when substantial differences in the number of genes or a high rate of divergence between species exists. Finally, we use neighbor-joining to recover phylogenies.
Results. Using the Open Tree of Life and NCBI Taxonomy Database as expected phylogenies, our approach compares well, recovering phylogenies that largely match expected trees and are comparable to trees recovered using maximum likelihood and other alignment-free approaches. Our technique is much faster than maximum likelihood and similar in accuracy to other alignment-free approaches. Therefore, we propose that codon aversion be considered a phylogenetically conserved character that may be used in future phylogenomic studies.
Availability. CAM, documentation, and test files are freely available on GitHub at https://github.com/ridgelab/cam