bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sağlıklı gebeliklerde fetal cinsiyet ile mikro RNA'ların ifade düzeyleri arasındaki ilişki
Authors: DEMİRER Selin , HOCAOĞLU Meryem , ÖZSAİT SELÇUK Bilge , TURGUT Abdulkadir , KÖMÜRCÜ BAYRAK Evrim 
Published: September 2019

SAĞLIKLI GEBELİKLERDE FETAL CİNSİYET İLE
MİKRORNA'LARIN İFADE DÜZEYLERİ ARASINDAKİ İLİŞKİÖzetAmaç:
Sağlıklı gebelikte maternal kan ve plasentaya özgü
miRNA’ların araştırılması, maternal/fetal biyolojik ve fizyolojik süreçlerin
anlaşılmasına yardımcı olmaktadır. Fetüste dişi ve erkek cinsiyet
arasındaki hormonal ve genetik farklılıkların sonucu olarak miRNA ifade
düzeyleri değişmektedir. Bu çalışmada amacımız, aday olarak belirlediğimiz
miRNA-21-3p, miRNA-155-5p, miRNA-518b ve miR-16-5p ifade düzeylerinin sağlıklı
gebelerde fetal cinsiyet ile ilişkisinin araştırılmasıdır.Gereçler
ve Yöntem: Çalışma grubu, Kasım 2017 – Mart 2018 tarihlerinde
İstanbul Medeniyet Üniversitesi Göztepe Eğitim ve Araştırma Hastanesi Kadın
Hastalıkları ve Doğum Kliniğinde gebeliği takip edilen, maternal ve/veya fetal
hastalık saptanmayan sağlıklı 21 gebeden oluşmaktadır. Maternal kan örnekleri
aynı gebelerin 29. (Grup 1) ve 37. gebelik (Grup 2) haftalarındaki takiplerinde
alınmıştır. Maternal kan
lökositlerinden RNA izolasyonunun ardından miR-21-3p, miR-155-5p, miR-518b ve
miR-16-5p anlatım düzeyleri, SYBR-Green gerçek zamanlı kantitatif PCR ile
belirlenmiştir. Gruplar ve fetal cinsiyetler arasındaki miRNA ifade düzeyleri
istatistiksel olarak karşılaştırılmıştır.Bulgular:
Grup
1 ve Grup 2’de fetal cinsiyet ile klinik ve biyokimyasal parametreler arasında
istatistiksel olarak anlamlı bir fark bulunmasa da (p&gt;0,05) miRNA ifade düzeyleri ilişkili
bulunmuştur. Buna göre, kız fetüs taşıyan gebelerde erkek fetüs taşıyanlara
oranla 29. haftada miR-16-5p (p=0,01) ifade düzeyinin artmış olduğu
belirlenmiştir. Erkek fetüs taşıyan gebelerde ise kız fetüs taşıyanlara oranla
37. haftada miR-21-3p (p=0,02), miR-155-5p (p=0,08) ve miR-518b (p=0,02) ifade
düzeylerinin artmış olduğu saptanmıştır.

Sonuç: İlk
defa bu çalışmada, sağlıklı gebelikte maternal kandaki lökositlerde üçüncü trimesterin
başında ve sonunda fetal cinsiyet ile değişen miRNA ifade düzeylerinin olduğu
gösterilmiştir.
Tıp Fakültesi Son Sınıf Öğrencilerinin Kariyer Tercihleri ve Bu Tercihleri Etkileyen Faktörler
Authors: TENGİZ Funda İfakat , BABAOĞLU Asya Banu 
Published: September 2019

Kariyer, genel anlamıyla seçilen bir iş hattında ilerlemek ve bunun sonucunda sorumluluk üstlenmek, statü kazanmak ve saygınlık elde etmek anlamını taşımaktadır. Bir kişinin iş yaşantısındaki aktivite, sorumluluk, tutum ve davranışlarının gelişimidir. Tıp fakültesi öğrencilerini mezuniyet sonrası temel, dâhili ve cerrahi bilimler alanlarında farklı düzey ve statüde kariyer olanakları beklemektedir. Bu çalışmada Tıp Fakültesi son sınıf öğrencilerinin kariyer tercihlerinin ne olduğu ve bu tercihlerini etkileyen faktörlerin belirlenmesi amaçlanmaktadır. Çalışmada karma araştırma yöntemi ve tamamlayıcılık deseni kullanılmıştır. Nicel ve nitel veriler eş zamanlı toplanmış ve bir yöntemden elde edilen bulguların detaylandırılması, sunulması, artırılması ve açıklığa kavuşturulmasında diğer yöntemin sonuçları kullanılmıştır. Veri toplama aracı olarak odak grup görüşmeleri ve kariyer tercih anketi kullanılmıştır. Yapılan odak grup görüşmeleri içerik çözümlemesi ile analiz edilmiştir. Transkriptleri çıkarıldıktan sonra kodlanıp, kategorize edilmiştir. Veri analizinde tanımlayıcı istatistikler ve Fisher’s Exact Test kullanılmıştır. Çalışmaya katılanların %60.9’u (n=28) kadın, genel yaş ortalaması 24.4 (±1.9) idi. Öğrencilerin %66.7’si (n=30) mezuniyet sonrasında dâhili, %28.9’u (n=13) cerrahi tıp bilimleri, %4.4’ü (n=2) temel bilimleri seçmeyi planlıyordu. Hiçbir öğrenci meslek hayatına pratisyen hekim olarak devam etmek istemiyordu. Öğrencilerin %84.8’i mezuniyet sonrasında “kamu hastanelerinde” çalışmak istediklerini ifade etti. “Yaşam tarzı esnekliği” ve “Kabul edilebilir çalışma saatleri” kariyer tercihini en çok etkilediği ifade edilen faktörlerdendi. Kariyer tercihini en az etkilediği tespit edilen faktörler ise “aile isteği” ve “sürekli mesleki gelişim için zaman ve para harcama zorunluluğu” ile “toplum tarafından algılanan statü” idi. Odak grup görüşmelerinden “ilgi, yetenek, para, saygınlık statü, kabul edilebilir ve yönetilebilir çalışma koşulları, dar ve odaklanmış ve genel uygulama alanı, TUS’dan alınan puan, mesleki tatmin, hastalar ve hasta yakınları ile ilişkiler, etik ilişkiler, yurtdışı olanaklar ve kariyer danışmanlığı” etkileyen faktörler olarak belirlenmiştir. Öğrencilerin kariyer planlamalarını yetenek ve ilgi alanlarına göre yapabilmelerini desteklemek ve sağlık alanında dengeli bir hizmet dağılımı sağlamak için, çalışma koşullarının düzenlenmesi yanında, mezuniyet öncesi eğitimde olumlu rol modellerinin varlığı ve kariyer danışmanlığı önem kazanmaktadır.
Myocardial Performance Index In Prediabetes In Medical Staff
Authors: Mahapatra Dr. Nancy Namrata , Kamble Dr. Tarachand Kadtuji 
Published: September 2019

Background: To study myocardial performance index in prediabetes in medical staff. To correlate MPI with cardiovascular risk factors.
Methods: After subject selection, informed consent was taken from the cases and controls. Detailed history was taken and physical examination was done which included weight, height, body mass index (BMI), waist circumference, hip circumference, waist-hip ratio (WHR) and blood pressure measurement. After physical examination, biochemistry measurements including fasting blood sugar (FBS), post-meal blood sugar (PMBS), serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were done. Myocardial performance index (MPI) was calculated by 2D-ECHO.
Results: BMI, male WHR, serum cholesterol, TG, LDL and MPI was significantly higher in cases (prediabetics) as compared to controls while serum HDL was lower in cases as compared to controls, which was non-significant. Out of 50 prediabetics, 32 (64%) had abnormal MPI with p=0.0001. There was no correlation of MPI with cardiovascular risk factors like BMI, WHR and fasting lipid profile.
Conclusion: BMI, male WHR, serum cholesterol, TG, LDL and MPI was significantly higher in cases as compared to controls. However, there was no significant correlation between MPI and other cardiovascular risk factors.
The Knowledge of Unsafe Abortion among the Youth: The Case of Tamale Metropolis in the Northern Region of Ghana
Authors: EM Der , SR Ndego , OS Larbi , A Opoku , V Nakong 
Published: September 2019

Background: Unsafe abortion contributes significantly to maternal deaths in Africa despite the availability of safe abortion services. This study assessed the knowledge of unsafe abortion among the youth within the Tamale Metropolis in the Northern region of Ghana.
Material and methods: This was a cross-sectional descriptive study using structured questionnaires. Data was analysed using SPSS version 23.0 (Chicago).
Result: The mean age of respondents was 23 ±10.4 years. The great majority (98.8%) (P<0.0001) have heard of unsafe abortion. The act is common among young, and unmarried women (P<0.0001). Unsafe abortion is commonly committed outside health facilities (70.9%; P<0.0001), in the communities (73.2%; P<0.0001), supervised by herbalists (53.9%), because of confidentiality (43.5%) and affordability (42.9%). Majority, (77.4%; P<0.0001) have heard of a method of unsafe abortion. The commonly used method was herbal preparation/medicine (264 (77.6%); P<0.0001). The two major reasons for unsafe abortion were: to allow the victim continue with education (47.4%) and to avoid difficulties in caring for the pregnancy and child (25.9%). Approximately, 99.4% (P<0.0001) were aware of some complications associated with unsafe abortion, particularly death (38.8%) and severe bleeding per vaginam (16.5%). A total of 78 (22.9%) have ever been pregnant, and 68 (87.2%) aborted the pregnancy because their partners did not allow them to keep the pregnancy. The great majority (83.8%) have unsafe abortion at home (59.6%).
Conclusion: Respondents had significant knowledge of unsafe abortion and the associated complications. Majority of the respondents who have ever been pregnant had unsafe abortion outside a health facility.
Comparison of the functional food knowledge-awareness levels and consumption frequencies of university students
Authors: Demir Hülya , Karakaya Başak 
Published: September 2019

Aim: The increase in the level of education brings with it many behavioral changes such as healthy nutrition in food purchasing behavior, flexibility against new products. The aim of this study is to create a perspective on whether nutrition and dietetics students' knowledge and awareness levels and functional frequencies are changed with theoretical knowledge.
Material and Method: The study consists of 1st and 4th year students in Nutrition and Dietetics Department studying in Private University. The number of students willing to participate voluntarily is 99. 55 (55.6%) of the students were in the 1st grade and 44 (44.4%) were in the 4th grade. The questionnaire used in the study was composed of parts such as demographic characteristics of the students and questions about functional food, functional food sections and the section on measuring the consumption frequency, judgments about functional foods, opinions about whether to prefer functional foods.
Results: When the study is examined according to educational level, 16,4% of 1st year students and 77.3% of 4th grade students have previously heard and are familiar with the term functional food. In this case, the rate of hearing the term functional food of 4th grade students was found to be statistically significantly higher than the first year students who have not yet received sufficient academic education. When the percentages of the 1st grade students were not aware of the functional foods and they did not know enough about the function of the product, the rate of not choosing was significantly higher than the 4th grade students.
Neurological Differences and Pharmaceuticals in Persons with Autism
Authors: Barnhart Gwendolyn 
Published: September 2019

Given the rise of persons diagnosed with autism, this paper is to highlight psychopharmacueticals that are often used in the treatment of autism symptomology. I begin with a brief summary of autism followed by a summation of biological differences. A discussion of pharmaceuticals often used to alleviate the symptoms associated with autism is also discussed. Lastly, a brief conclusory statement is provided.
Experimental and modeling study of polyphenols in Olea europaea leaves through ultrasound-assisted extraction
Authors: ŞAHİN SEVGİLİ Selin 
Published: September 2019

Olive tree (Olea europaea) leaves were extracted by ultrasound-assisted extraction (UAE). The
attention was focused on the yield of extract and its polyphenols, and
extraction kinetics to contribute to
the application of the extraction process industrially. Samples were extracted
with water, ethanol, methanol, and their aqueous solutions (50%, v/v) under
temperature values ranging from 30 to 50 °C. Additionally, the temperature
interval changed between 30 and 80 °C, when water was used as solvent. Backing the solvents with water
enhanced the polyphenolic yield. Total phenolic content (TPC) from water
extracts decreased after a certain temperature point, as a result of
degradation problems. The second-order model was followed for characterizing the kinetic of the
UAE process of TPC from olive leaves under various solvents and temperatures. Major
phenolic component was also quantified for each solvent system by means of High Performance Liquid
Chromatography (HPLC).
Characterization of Gelatin Profile of Chicken Broiler (Gallus domestica) Bone Using SDS-PAGE Electrophoresis
Authors: Yuliani Dewi , Awalsasi Dhienda Risa , Jannah Akyunul 
Published: September 2019

<p>Gelatin, a proteinaceous additive, is obtained from hydrolysis of collagen in the bone, hide and skin of animals. As natural product, gelatin has been applied in many industries with various functions. This study attempt to characterize gelatin profile of broiler chicken (<em>Gallus domestica</em>) using SDS-PAGE electrophoresis. The chicken bone was pretreated using a strong base, sodium hydroxide, producing type B gelatin. The gelatin was purified through precipitation using the variation of ammonium sulfate concentrations (40-70%) and dialysis using cellophane membrane. The purified gelatin was characterized through SDS-PAGE electrophoresis. Based on electrophoresis visualization, reduction of band intensity by ammonium sulfate 40% showed removal of small peptide fragments. The remained gelatin showed two major bands, α-chains and a β-chain with the respective molecular weight of ~135 and ~245 kDa. The protein content of the unpurified gelatin (E1) was 71.65±0.60 mg/L. The purified E1 gelatins by 40-70% of ammonium sulfate addition contained 61.42±3.90, 60.45±1.36, 59.89±0.24, and 55.32±1.05 mg/L of protein concentration, respectively.</p><p> </p><p>Keywords: chicken bone, gelatin profile, protein electrophoresis</p>
Assessing Patient Motivation for Treatment: A Systematic Review of Available Tools, Their Measurement Properties, and Conceptual Definition
Authors: Shankar Sneha , Miller William C. , Roberson Nathan D. , Hubley Anita M. 
Published: September 2019

Background and PurposeMotivation is often reported by clinicians and researchers as a key factor related to treatment and health outcomes. This systematic review aims to (a) Identify and critically appraise tools that measure patient motivation for treatment and (b) determine how these tools define and evaluate motivation.MethodsLibrary databases and the search engine Google Scholar were examined. Identified tools measuring patient motivation for treatment and reported measurement properties were selected.Results14 peer-reviewed articles covering 12 different tools made the final selection. Quality was assessed using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) and a new measure checklist. Reliability evidence was predominantly estimated using internal consistency; validity evidence was limited, and responsiveness was seldom examined. Overall, quality ratings were poor or inadequately reported and serious methodological limitations were identified. A lack of conceptual foundation quality ratings as tools did not apply a theory related to motivation or have a clear definition of the construct of patient motivation.ConclusionsA significant gap exists of available tools with adequate measurement properties that use relevant theoretical frameworks.
Coping Among Breast Cancer Survivors: A Confirmatory Factor Analysis of the Brief COPE
Authors: Rand Kevin L. , Cohee Andrea A. , Monahan Patrick O. , Wagner Lynne I. , Shanahan Mackenzie L. , Champion Victoria L. 
Published: September 2019

Background and PurposeCancer survivors continue to cope with significant stressors after completing treatment. The Brief COPE (Carver, 1997) is frequently used to measure coping; however, its factor structure remains unclear. The purpose of this study was to determine the best factor conceptualization of the Brief COPE for use among breast cancer survivors.MethodsBreast cancer survivors (N = 1,127) completed the Brief COPE. We conducted confirmatory factor analyses comparing several a priori models based on research in cancer-relevant populations.ResultsOf the eight models examined, the 14-factor model of the Brief COPE showed the best fit.ConclusionsDespite efforts to simplify the structure of the Brief COPE, our results suggest coping among breast cancer survivors is best assessed using Carver's (1997) original 14-factor conceptualization.
The Construction and Validation of a Self-Efficacy Instrument for New Graduate Nurses in a Transition to Practice Program
Authors: Shinners Jean S. , Africa Larissa 
Published: September 2019

Background and PurposeTransition to practice programs are an expectation for new graduate RNs and there is a need for quality outcome measures. The concept of self-efficacy was explored, and a tool developed, to identify the RN's belief regarding their capacity to perform select clinical competencies. The purpose of this study was to validate the psychometric properties of the Versant Self-Efficacy tool.MethodsA cross-sectional analysis was conducted on data obtained between July 1, 2015, and December 31, 2016. The sample included 901 new graduate RNs at multisite locations. Reliability and validity of the tool was examined.ResultsThe Versant Self-Efficacy tool demonstrated positive results for factor structure and internal reliability.ConclusionThe Self-Efficacy tool has proven to be a robust, psychometrically sound tool to measure the self-efficacy of new graduate RNs.
Development and Psychometric Assessment of Risk Factors of Compassion Fatigue Inventory in Nurses
Authors: Sabery Mahdieh , Tafreshi Mansoureh Zagheri , Hosseini Meimanat , Mohtashami Jamileh , Ebadi Abbas 
Published: September 2019

Background and PurposeIdentifying the risk factors of compassion fatigue is the basic step in designing effective interventions to prevent and manage compassion fatigue. This study developed an inventory of compassion fatigue risk factors and investigated its psychometric properties.MethodsThis methodological study consisted of two phases: item pool generation through semistructured interviews with 13 nurses and reviewing of 38 related articles and the psychometric validation.ResultsThe initial item pool contained 62 items. The psychometric properties was examined and exploratory factor analysis revealed a four-factor structure. Risk Factors of Compassion Fatigue Inventory (RFCFI) contained 20 items. The Cronbach's alpha, intra-class correlation coefficient (ICC), and standard error of measurement (SEM) were .86, 0.83, and 5.73 respectively.ConclusionRFCFI is a short, self-reporting, valid, and reliable inventory for determining the risk factors of compassion fatigue in nurses and can be easily used by managers, nurses, and scholars.
Taquicardia Sinusal em Adolescentes: A Importância do Diagnóstico Diferencial
Authors: Oliveira Inês , Teles Hugo , Seixo Filipe , Ferrão Anabela 
Published: September 2019

A taquicardia sinusal é uma manifestação comum em Pediatria, associada frequentemente a condições fisiológicas, nomeadamente as síndromes de somatização. Pode ser um sinal precoce de patologias graves, com prognóstico adverso. Adolescente de 15 anos, sexo feminino, saudável e sob anticoncetivos orais desde há um mês. Admitida no serviço de urgência por lipotimia. Estava assintomática e não apresentava alterações ao exame objetivo, à exceção de taquicardia sinusal persistente, apesar da estabilidade hemodinâmica. A angio-tomografia computorizada torácica revelou trombos nas artérias pulmonares principais, confirmando o diagnóstico de embolia pulmonar bilateral. Foi iniciada hipocoagulação com boa evolução. A embolia pulmonar em idade pediátrica é rara, embora provavelmente sub-diagnosticada pela apresentação clínica inespecífica, que pode conduzir ao atraso diagnóstico e, consequentemente, agravar o prognóstico.
Contraceção em Adolescentes: Conhecimentos e Práticas em Portugal
Authors: Miranda Patrícia , Moleiro Pascoal , Gaspar Pedro , Luz Alexandra 
Published: September 2019

Introdução: Os adolescentes são um grupo de intervenção prioritária em saúde reprodutiva. Os médicos de medicina geral e familiar, ginecologistas e pediatras são os principais responsáveis pelo aconselhamento contracetivo.Material e Métodos: Estudo transversal, correlacional, de natureza quantitativa, aprovado pela comissão de ética do Centro Hospitalar de Leiria. Dados colhidos em questionário online validado (alfa de Cronbach e Análise Fatorial Exploratória), constituído por itens de tipo diferencial semântico, com cinco pontos (“Discordo totalmente — 1” e “Concordo totalmente — 5”). Pontuações mais elevadas conotam-se com maior conhecimento ou adequabilidade na questão. Análise por género, especialidade, anos de carreira e grau de formação: especialista, interno de formação específica.Resultados: Obtiveram-se 338 respostas (51% médicos de medicina geral e familiar, 29% pediatras, 20% ginecologistas). Do total, 66% eram especialistas, 36% tinham menos de cinco anos de carreira e 17% tinham mais de 20 anos de carreira. O conhecimento das recomendações foi superior entre os ginecologistas [4,38 (1,09); p < 0,001] e no género feminino [3,65 (1,41); p = 0,039] com diferença estatisticamente significativa. Os ginecologistas receberam mais formação recentemente [3,79 (1,42)] e consideram estar atualizados [4,41 (0,70), p < 0,001].Discussão: O questionário revelou validade e fiabilidade. Os ginecologistas estão mais familiarizados com a contraceção na adolescência, enquanto pediatras e clínicos mais novos referem maior necessidade de atualização. Os ginecologistas receberam formação recentemente e consideram estar atualizados, pelo que a formação na área parece ter impacto positivo.Conclusão: O conhecimento acerca do aconselhamento contracetivo ainda não é ótimo, pelo que é fundamental investir na formação dos profissionais de saúde.
Subtelomeric Rearrangements: Presentation of 21 Probands with Emphasis on Familial Cases
Authors: Soares Ana Rita , Soares Gabriela , Mota-Freitas Manuela , Oliva-Teles Natália , Fortuna Ana Maria 
Published: September 2019

Introduction: Intellectual disability affects 2% – 3% of the general population, with a chromosomal abnormality being found in 4% – 28% of these patients and a cryptic subtelomeric abnormality in 3% – 16%. In most cases, these subtelomeric rearrangements are submicroscopic, requiring techniques other than conventional karyotype for detection. They may be de novo or inherited from an affected parent or from a healthy carrier of a balanced chromosomal abnormality. The aim of this study was to characterize patients from our medical genetics center, in whom both a deletion and duplication in subtelomeric regions were found.Material and Methods: Clinical and cytogenetic characterization of 21 probands followed at our center, from 1998 until 2017, with subtelomeric rearrangements.Results: There were 21 probands from 19 families presenting with intellectual disability and facial dysmorphisms. Seven had behavior changes, five had epilepsy and 14 presented with some other sign or symptom. Four had chromosomal abnormalities detected by conventional karyotype and four were diagnosed by array-comparative genomic hybridization. In four cases, parental studies were not possible. The online mendelian inheritance in man classification was provided whenever any of the phenotypes (deletion or duplication syndrome) was dominant.Discussion: Patients and relevant family members were clinically and cytogenetically characterized. Although rare, subtelomeric changes are a substantial cause of syndromic intellectual disability with important familial repercussions. It is essential to remember that a normal array-comparative genomic hybridization result does not exclude a balanced rearrangement in the parents.Conclusion: Parental genetic studies are essential not only for a complete characterization of the rearrangement, but also for accurate genetic counselling and screening of family members at risk for recurrence.