bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological underarousal as a mechanism of aggressive behavior in university athletes with a history of concussion
Authors: Gallant Caitlyn , Barry Nicole , Good Dawn 
Published: July 2018

AbstractIntroductionResearch has indicated that athletes who engage in high‐risk athletic activities, such as football and hockey, have riskier personalities than their low‐risk and nonathlete counterparts (Ahmadi et al., 2011, Procedia Soc Behav Sci, 30 and 247–251; Zuckerman, 1983, Biological bases of sensation seeking, impulsivity, and anxiety, Lawrence Erlbaum Assoc Inc.). For instance, increased sensation‐seeking and aggression are common in high‐risk athletes, rendering these individuals more likely to sustain a subsequent injury, such as concussion. Elevated levels of certain personality traits, including impulsivity and aggression, have also been observed after concussion (Goswami et al., 2016, Brain Struct Funct, 221 and 1911–1925). The purpose of this study therefore was to determine whether aggressive behavior in university athletes may be accounted for, in part, by a history of concussion, rather than exclusively athletic status.MethodsUsing a quasi‐experimental design, 66 university students (n = 18 nonathletes, n = 24 low‐risk athletes, n = 24 high‐risk athletes) with (n = 27) and without a history of concussion (n = 39) completed the Buss & Perry Aggression Questionnaire (BPAQ; Buss & Perry, , J Pers Soc Psychol, 63 and 452) and provided electrodermal activation (EDA) as an index of physiological arousal.ResultsIt was found that decreased physiological arousal among students with a history of concussion was associated with greater endorsement of physical aggression. Moreover, athletic status did not account for this pattern of aggression, as athletes and nonathletes did not differ in terms of self‐reported aggressive tendencies.ConclusionsPhysiological compromise after concussive injury may act as an independent mechanism of aggressive behavior in athletes beyond factors, such as athletic status.
Long noncoding RNA LINC00152 promotes cell proliferation through competitively binding endogenous miR‐125b with MCL‐1 by regulating mitochondrial apoptosis pathways in ovarian cancer
Authors: Chen Puxiang , Fang Xiaolin , Xia Bing , Zhao Yan , Li Qiaoyan , Wu Xiaoying 
Published: July 2018

AbstractRecently, an increasing number of studies have focused on the key function of long noncoding RNAs (lncRNAs) in biological activity. Abnormal lncRNA expression was found to relate to the development and pathogenesis of multiple cancers. LncRNA LINC00152 served as an oncogene in multiple cancers; however, its role in ovarian cancer remains unknown. In our research study, LINC00152 was upregulated in ovarian cancer tissues and cell lines. An increasing LINC00152 level was positively correlated with the histological grade, clinical stage, and poor prognosis of ovarian cancer patients. In addition, knockdown of LINC00152 reduced cell growth, induced cell apoptosis, and suppressed tumor growth. Moreover, we revealed that LINC00152 and Myeloid cell leukemia‐1 (MCL‐1) were targeted by miR‐125b and had the same miR‐125b combining site. The miR‐125b level was negatively correlated with the expression of LINC00152, while MCL‐1 was positively related to the LINC00152 level. MiR‐125b could affect LINC00152 levels as evaluated by qRT‐PCR. Finally, we affirmed that LINC00152 mediated cell proliferation by affecting MCL‐1 expression and MCL‐1‐mediated mitochondrial apoptosis pathways and by working as a competitive endogenous RNA (ceRNA) of miR‐125b. In summary, based on ceRNA theory, the combined research on miR‐125b and MCL‐1, and taking LINC00152 as a new study point, we provide new insight into the molecular mechanism of reversing cell proliferation in ovarian cancer.
Molecular heterogeneity in human papillomavirus‐dependent and ‐independent vulvar carcinogenesis
Authors: Swarts Dorian R. A. , Voorham Quirinus J. M. , van Splunter Annina P. , Wilting Saskia M. , Sie Daoud , Pronk Divera , van Beurden Marc , Heideman Daniëlle A. M. , Snijders Peter J. F. , Meijer Chris J. L. M. , Steenbergen Renske D. M. , Bleeker Maaike C. G. 
Published: July 2018

AbstractVulvar squamous cell carcinoma (VSCC) and precancerous vulvar intraepithelial neoplasia (VIN) can develop through human papillomavirus (HPV)‐dependent and ‐independent pathways, indicating a heterogeneous disease. Only a minority of VIN progress, but current clinicopathological classifications are insufficient to predict the cancer risk. Here we analyzed copy number alterations (CNA) to assess the molecular heterogeneity of vulvar lesions in relation to HPV and cancer risk. HPV‐status and CNA by means of whole‐genome next‐generation shallow‐sequencing were assessed in VSCC and VIN. The latter included VIN of women with associated VSCC (VINVSCC) and women who did not develop VSCC during follow‐up (VINnoVSCC). HPV‐testing resulted in 41 HPV‐positive (16 VINVSCC, 14 VINnoVSCC, and 11 VSCC) and 24 HPV‐negative (11 VINVSCC and 13 VSCC) lesions. HPV‐positive and ‐negative VSCC showed a partially overlapping pattern of recurrent CNA, including frequent gains of 3q and 8q. In contrast, amplification of 11q13/cyclinD1 was exclusively found in HPV‐negative lesions. HPV‐negative VINVSCC had less CNA than HPV‐negative VSCC (P = .009), but shared chromosome 8 alterations. HPV‐positive VINnoVSCC had less CNA than VINVSCC (P = .022). Interestingly, 1pq gain was detected in 81% of HPV‐positive VINVSCC and only in 21% of VINnoVSCC (P = .001). In conclusion, HPV‐dependent and ‐independent vulvar carcinogenesis is characterized by distinct CNA patterns at the VIN stage, while more comparable patterns are present at the cancer stage. Cancer risk in VIN seems to be reflected by the extent of CNA, in particular chromosome 1 gain in HPV‐positive cases.
Integrating value of research into NCI Clinical Trials Cooperative Group research review and prioritization: A pilot study
Authors: Carlson Josh J. , Kim David D. , Guzauskas Gregory F. , Bennette Caroline S. , Veenstra David L. , Basu Anirban , Hendrix Nathaniel , Hershman Dawn L. , Baker Laurence , Ramsey Scott D. 
Published: July 2018

AbstractBackgroundThe Institute of Medicine has called for approaches to help maximize the return on investments (ROI) in cancer clinical trials. Value of Research (VOR) is a health economics technique that estimates ROI and can inform research prioritization. Our objective was to evaluate the impact of using VOR analyses on the clinical trial proposal review process within the SWOG cancer clinical trials consortium.MethodsWe used a previously developed minimal modeling approach to calculate VOR estimates for 9 phase II/III SWOG proposals between February 2015 and December 2016. Estimates were presented to executive committee (EC) members (N = 12) who determine which studies are sent to the National Cancer Institute for funding consideration. EC members scored proposals from 1 (best) to 5 based on scientific merit and potential impact before and after receiving VOR estimates. EC members were surveyed to assess research priorities, proposal evaluation process satisfaction, and the VOR process.ResultsValue of Research estimates ranged from −$2.1B to $16.46B per proposal. Following review of VOR results, the EC changed their score for eight of nine proposals. Proposal rankings were different in pre‐ vs postscores (P value: 0.03). Respondents had mixed views of the ultimate utility of VOR for their decisions with most supporting (42%) or neutral (41%) to the idea of adding VOR to the evaluation process.ConclusionsThe findings from this pilot study indicate use of VOR analyses may be a useful adjunct to inform proposal reviews within NCI Cooperative Clinical Trials groups.
Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma
Authors: Imai Reiko , Kamada Tadashi , Araki Nobuhito ,   and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas
Published: July 2018

AbstractCarbon ion radiotherapy is known for its high‐precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients’ median age was 54 years, and the median follow‐up period was 49.4 (range 6.4‐146.4) months. The median tumor volume was 356 cm3. The 5‐year local control, overall survival, and disease‐free survival rates were 65%, 46%, and 39%, respectively. In the univariate analysis, tumor volume, local control, and incidences of metastases were significantly related to overall survival. In the multivariate analysis, tumor volume and local control were significantly related to overall survival. We did not find any factors related to local control. Five patients required surgical intervention because of adverse events in the bones. Carbon ion radiotherapy may be a treatment option for unresectable axial soft tissue sarcoma.
Self‐evaluation of duration of adjuvant chemotherapy side effects in breast cancer patients: A prospective study
Authors: Galizia Danilo , Milani Andrea , Geuna Elena , Martinello Rossella , Cagnazzo Celeste , Foresto Manuela , Longo Virginia , Berchialla Paola , Solinas Gianfranca , Calori Adele , Grasso Bruna , Volpone Chiara , Bertola Gisella , Parola Gisella , Tealdi Giancarla , Giuliano Piero Luigi , Ballari Anna Maria , Aglietta Massimo , Montemurro Filippo 
Published: July 2018

AbstractBackgroundWe recently reported that self‐evaluation of the incidence and severity of treatment‐related side effects (TSEs) using a National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v4.0‐based questionnaire was feasible and more informative than doctor reports in patients undergoing standard adjuvant chemotherapy for operable breast cancer. Here, we compare self‐ and doctor‐evaluated day of onset and duration of TSEs in the same population.Patients and methodsSix hundred and four patients were enrolled at 11 sites in Italy. CTCAE v4.0 definitions of grade of severity of nausea, vomiting, constipation, anorexia, dysgeusia, diarrhea, fatigue, pain, paresthesia, and dyspnea were translated into Italian and rephrased. Questionnaires were administered after the first and third chemotherapy cycles. At each time‐point, information on TSEs was extracted from the medical charts and compared to patient questionnaires.ResultsA total of 594 and 573 paired patient and doctor questionnaires were collected after cycles one and three, respectively. TSE duration was significantly longer when reported by patients compared to doctors for six and seven of ten items after cycles one and three, respectively. Due to the combined effect of doctor underreporting of TSE incidence and duration, the mean percentages of cycle days with TSEs were significantly higher for all ten items when based on patient reports. Day of onset could not be evaluated because of insufficient numbers of complete records.ConclusionsSelf‐reporting TSE duration is feasible using a CTCAE‐derived questionnaire. As doctors tend to underestimate TSE incidence and duration, patient‐reported outcomes should be incorporated into clinical practice, perhaps using eHealth technologies, to harness their potential to better estimate total TSE burden.
Serum type XVI collagen is associated with colorectal cancer and ulcerative colitis indicating a pathological role in gastrointestinal disorders
Authors: Jensen Christina , Nielsen Signe H. , Mortensen Joachim H. , Kjeldsen Jens , Klinge Lone G. , Krag Aleksander , Harling Henrik , Jørgensen Lars N. , Karsdal Morten A. , Willumsen Nicholas 
Published: July 2018

AbstractAltered extracellular matrix (ECM) remodeling is an important part of the pathology of gastrointestinal (GI) disorders. In the intestine, type XVI collagen (col‐16) plays a role in pathogenesis by affecting ECM architecture and induce cell invasion. Measuring col‐16 in serum may therefore have biomarker potential in GI disorders such as colorectal cancer (CRC) and ulcerative colitis (UC). The aim of this study was to determine whether col‐16 can serve as a biomarker for altered ECM remodeling in patients with CRC and UC. A monoclonal antibody was raised against the C‐terminal end of col‐16 (PRO‐C16), and a competitive enzyme‐linked immunosorbent assay (ELISA) was developed and technically validated. Levels of PRO‐C16 were measured in serum from patients with CRC (before (n = 50) and 3 months after (n = 23) tumor resections), UC (n = 39) and healthy controls (n = 50). The PRO‐C16 ELISA was specific toward the C‐terminal of col‐16. PRO‐C16 was significantly elevated both in serum from patients with CRC (P = 0.0026) and UC (P < 0.0001) compared to controls. No difference was detected in levels of PRO‐C16 between patients with CRC at baseline and 3 months after tumor resections (P > 0.999). Levels of PRO‐C16 identified patients with a GI disorder with a positive predictive value of 0.9 and an odds ratio of 12 (95%CI = 4.5‐29.5, P < 0.0001). The newly developed assay detected significantly elevated levels of PRO‐C16 in serum from patients with GI disorders compared to controls suggesting its potential as a biomarker in this setting. Future studies are needed to validate these findings.
Novel TRPV4 variant causes a severe form of metatropic dysplasia
Authors: Graversen Lise , Haagerup Annette , Andersen Brian N. , Petersen Karin K. , Gjørup Vibike , Gudmundsdottir Gudrun , Vogel Ida , Gregersen Pernille A. 
Published: July 2018

Key Clinical MessageWe present a girl born with a frontal bossing, short neck, bell‐shaped thorax, short limbs with prominent joints, and a tail‐like coccygeal appendage. Genetic screening of TRPV4 identified a novel de novo heterozygous missense variant. We believe the variant causes the severe form of metatropic dysplasia in this patient.
Refractory chronic “ITP”: When platelet size matters
Authors: Baliakas Panagiotis , Kättström Magdalena , Rossing Maria , Amini Rose‐Marie 
Published: July 2018

Key Clinical MessageInherited conditions associated with thrombocytopenia should be included in the differential diagnosis of young patients with refractory immune thrombocytopenia (ITP), even in the absence of a positive family history. Early identification of such conditions is of vital importance in order to reach the right diagnosis and avoid unnecessary or even harmful medication.
A Systematic (Spectro‐) Electrochemical Approach to the Synthesis and Characterisation of Co(II) and Ni(II) Compounds Containing Reduced Forms of TCNQF
Authors: Vo Nguyen T. , Martin Lisandra L. , Bond Alan M. 
Published: July 2018

AbstractThe electrochemistry of TCNQF (2‐fluoro‐7,7,8,8‐tetracyanoquinodimethane) in acetonitrile (0.1 M Bu4NPF6) in the presence of either Co2+ or Ni2+ is reported. Cyclic voltammetry over an extensive range of potentials revealed that the reduction of TCNQF to either TCNQF1− or the TCNQF2− species provides a route for electrocrystallisation of the respective M(TCNQF)2(H2O)2 and M(TCNQF) materials on the electrode surface. These materials were independently prepared by addition of the corresponding metal salts to a solution of either TCNQF1− or TCNQF2− prepared by bulk electrolysis. Comprehensive characterisation of these solids by Infrared and Raman spectroscopy indicated that the M(TCNQF)2(H2O)2 complexes were similar to other transition metal complexes in the M(TCNQX)2(S)2 series where S=solvent (H2O or CH3OH) and X = H4 or F4. The M(TCNQF) materials containing the TCNQF2− anion were not stable in air, similar to the highly air‐sensitive TCNQ2− derivatives. Scanning Electron Microscopy (SEM) images of electrocrystallised samples of Ni(TCNQF)2(H2O)2 were rod‐like, whereas the Co(TCNQF)2(H2O)2 formed needles. Energy‐dispersive X‐ray spectroscopy (EDX) analysis of these samples together with elemental microanalysis and thermogravimetric analysis (TGA) supported the composition and stoichiometry. The solubility products (Ksp values) of M(TCNQF)2(H2O)2 materials were determined spectrophotometrically and voltammetrically in acetonitrile, where Ksp for Co(TCNQF)2(H2O)2 was 3.37×10−11 M3 (or 1.14×10−10 M3 in the presence of electrolyte, 0.1 M Bu4NPF6) and Ni(TCNQF)2(H2O)2 was 5.54×10−12 M3 (or 2.65×10−10 M3 in the presence of electrolyte, 0.1 M Bu4NPF6).
Cobalt Oxide Materials for Oxygen Evolution Catalysis via Single‐Source Precursor Chemistry
Authors: Kuznetsov Denis A. , Konev Dmitry V. , Sokolov Sergey A. , Fedyanin Ivan V. 
Published: July 2018

AbstractThe utilization of metal alkoxides as single‐source precursors for (mixed‐)oxide materials offers remarkable benefits, such as the possibility to precisely control the metal ratio in the resulting material, highly homogeneous distribution of the elements in the film, and the low temperatures required for film processing. Herein we report on the isolation and characterization of the bimetallic Co‐Mo alkoxide [Co3Mo4O10(OCH3)10(dmf)4] (Co3Mo4; dmf=N,N‐dimethylformamide), which was prepared by the anion metathesis reaction of the corresponding metal chlorides. The Co‐Mo alkoxide was explored as a well‐defined precursor of cobalt oxide catalysts for the oxygen evolution reaction (OER) in alkaline electrolyte MOH. The catalysts demonstrated excellent activity in the OER, manifested in low onset potentials and Tafel slopes and superb stability under the operating conditions both in alkaline and nearly neutral media. It was observed that the nature of the metal cation of the alkaline electrolyte MOH (M+=Li+, Na+, K+, Cs+) greatly affected the catalytic performance of the material. We propose that the positive effect of larger metal cations on the film activity in the OER could be explained by the higher hydration enthalpies of larger ions and enhanced mass transport within a larger interlayer space between the [CoO2]δ−∞ sheets of the in situ formed binary oxides. It may be deduced that this trend is universal and may be extended to other types of metal oxides forming layered structures during the OER.
Molecular Deformation, Charge Flow, and Spongelike Behavior in Anion–π {[M(CN)4]2−;[HAT(CN)6]}∞ (M=Ni, Pd, Pt) Supramolecular Stacks
Authors: Kuzniak Emilia , Pinkowicz Dawid , Hooper James , Srebro‐Hooper Monika , Hetmańczyk Łukasz , Podgajny Robert 
Published: July 2018

AbstractThe synthesis, crystal structures, spectroscopic characterization, and comprehensive quantum‐chemical calculations for a novel series of anion–π hybrid salts (XPh4)2[M(CN)4][HAT(CN)6]⋅3 MeCN (X=P, M=NiII (1), PdII (3), PtII (5); X=As, M=NiII (2), PdII (4), PtII (6); HAT(CN)6=1,4,5,8,9,11‐hexaazatriphenylenehexacarbonitrile) are presented. The systems comprise 1D {[M(CN)4]2−;[HAT(CN)6]}∞ stacks, in which the electron‐rich metal complexes adjust their orientation to match the electron‐deficient areas of HAT(CN)6. Electronic charge‐transfer interactions along the stacks result in polarization of electron density within HAT(CN)6 and in perturbations along the {[M(CN)4]2−;[HAT(CN)6]}∞ contacts. Electronic structure analysis suggests, for example, a relocation of 0.1–0.2 e per molecule from [M(CN)4]2− to HAT(CN)6 and anion–π interaction energies of around −65 kcal mol−1. A reversible structural single‐crystal‐to‐single‐crystal transformation, through desolvation/resolvation processes in the solid state, is also reported and a scheme for the formation of anion–π [M(CN)4]2−/HAT(CN)6 adducts in MeCN is proposed.
A Shape‐Adaptable Organometallic Supramolecular Coordination Cage for the Encapsulation of Fullerenes
Authors: Martínez‐Agramunt Víctor , Gusev Dmitry G. , Peris Eduardo 
Published: July 2018

AbstractThe development of three‐dimensional supramolecular coordination complexes (SCCs), with cavities suitable for guest binding, is of great interest because these materials are useful in a large number of applications. Herein, a nickel‐conjoined organometallic molecular prism is described, which has been fully characterized. The X‐ray diffraction structure of the molecule reveals that the cage possesses an internal cavity with a volume of 1028 Å3, thus suitable for the encapsulation of large 3D‐molecules, such as fullerenes. This cage shows highly selective complexation of C70 over C60, thus being potentially useful for fullerene separation and purification. The combined experimental and computational studies suggest that the complexation process is largely entropically‐driven, and DFT calculations suggest that the cage is flexible and can adapt the size and the shape of the cavity to maximize the face‐to‐face interaction with the fullerenes.
Effect of text‐background lightness combination on visual comfort for reading on a tablet display under different surrounds
Authors: Huang Hsin‐Pou , Wei Minchen , Ou Li‐Chen 
Published: July 2018

AbstractMany tablets are designed to change display brightness or color with surround for enhancing visual comfort. Although both color and brightness of a surround may vary a lot, few studies investigated how text‐background lightness combination of a tablet display and surround jointly affect visual comfort, and how display white point affects visual comfort. In this study, 20 observers evaluated visual comfort of 20 text‐background lightness combinations of a 9.7‐inch tablet display through paired comparisons under five surrounds—a dark surround and four ambient lighting conditions comprising two levels of correlated color temperature (CCT)—3500 and 6500 K—and illuminance—300 and 3000 lx. The combination of a black text and a light‐gray background (i.e., L*background = 75.33; L*text = 1.6) was evaluated the most comfortable when there was ambient light regardless of CCT and illuminance. It was also evaluated the third most comfortable under the dark surround. The observers also evaluated the visual comfort of a dark text on five different white backgrounds under 3500 and 6500 K at 1000 lx. The color of the background that was judged as the most comfortable neither had the whitest appearance nor matched the color of the ambient light. The simultaneous adjustment of the display white point and the text‐background lightness combination merits further investigations.
Modulation of Solvation and Molecular Recognition of a Lipid Bilayer under Dynamical Phase Transition
Authors: Singh Priya , Choudhury Susobhan , Sharma V. K. , Mitra S. , Mukhopadhyay R. , Das Ranjan , Pal Samir Kumar 
Published: July 2018

AbstractIt is well accepted in contemporary biology that an ∼30 Å thick lipid bilayer film around living cells is a matter of life and death as the film typically delimits the environments that serve as a crucial margin. The dynamic organization of lipid molecules both across the lipid bilayer and in the lateral dimension are known to be crucial for cellular transport and molecular recognition by important biological macromolecules. Here, we study dilute (20 mM) Dioctadecyldimethylammonium bromide (DODAB) vesicles at different temperatures in aqueous dispersion with well‐defined phases namely liquid crystalline, gel and subgel. The spectroscopic studies on two fluorescent probes 8‐anilino‐1‐naphthalene sulfonic acid ammonium salt (ANS) and Coumarin 500 (C500), former in the head group region of the lipid‐water interface and later located deeper in the lipid bilayer follow dynamics (solvation and fluidity) of their local environments in the vesicles. Binding of an anti‐tuberculosis drug rifampicin has also been studied employing Förster resonance energy transfer (FRET) technique. The molecular insight concerning the effect of dynamical organization of the lipid molecules on the local dynamics of aqueous environments in different phases leading to molecular recognition becomes evident in our study.