bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galectin-3 and S100A9: Novel Diabetogenic Factors Mediating Pancreatic Cancer–Associated Diabetes
Authors: Liao Wei-Chih , Huang Bo-Shih , Yu Ya-Han , Yang Hsin-Hua , Chen Peng-Ruei , Huang Cheng-Chieh , Huang Hsin-Yi , Wu Ming-Shiang , Chow Lu-Ping 
Published: July 2019

OBJECTIVE
Pancreatic cancer–associated diabetes (PCDM) is a paraneoplastic phenomenon accounting for 1% of new-onset diabetes. We aimed to identify the mediators of PCDM and evaluate their usefulness in distinguishing PCDM from type 2 diabetes.

RESEARCH DESIGN AND METHODS
Secreted proteins of MIA PaCa-2 cells were identified by proteomics, and those with ≥10-fold overexpression in transcriptome analysis were assessed by bioinformatics and glucose uptake assay to identify candidate factors. Expression of factors was compared between tumors with and without PCDM by immunohistochemistry. Serum levels were measured in a training set including PC with and without PCDM, type 2 diabetes, pancreatitis, other pancreatic/peripancreatic tumors, and control subjects (n = 50 each). Cutoff values for differentiation between PCDM and type 2 diabetes from the training set were validated in a test set (n = 41 each).

RESULTS
Galectin-3 and S100A9 were overexpressed in tumors with PCDM and dose-dependently suppressed insulin-stimulated glucose uptake in C2C12 myotubes. In the training set, serum galectin-3 and S100A9 levels were exclusively increased in patients with PCDM and distinguished PCDM from type 2 diabetes (area under the curve [AUC] galectin-3: 0.73 [95% CI 0.64–0.83]; S100A9: 0.79 [95% CI 0.70–0.87]). Similar results were observed in the test set (AUC galectin-3: 0.83 [95% CI 0.74–0.92]; S100A9: 0.77 [95% CI 0.67–0.87]), with sensitivity and specificity 72.1% and 86.1%, respectively, for galectin-3 and 69.8% and 58.1% for S100A9 in differentiating between PCDM and type 2 diabetes.

CONCLUSIONS
Galectin-3 and S100A9 are overexpressed in PCDM tumors and mediate insulin resistance. Galectin-3 and S100A9 distinguish PCDM from type 2 diabetes in subjects with new-onset diabetes.
Arqueología en el Valle de Tafí (provincia de Tucumán): algunas miradas sobre el pasado-presente de su gente
Authors: Manasse Bárbara 
Published: July 2019

En este artículo nos proponemos exponer una mirada del ?pasado ? presente? de la gente nativa del Valle de Tafí en la provincia de Tucumán. Lo abordaremos desde la arqueología, de la mano de los saberes de la población indígena trazando una historia que, partiendo de los datos científicos más antiguos que disponemos, llega a la actualidad en sus intereses, sus urgencias y sus luchas. Dos ejes concentran nuestra atención: el Valle como territorio ancestral y la continuidad histórica de su uso y percepción como tal. Las Comunidades Indígenas de Tafí encuentran en la arqueología una herramienta de colonización, pero también de reconciliación, reconocimiento y lucha. En un ir y venir de intereses y conocimientos venimos trabajando en una práctica que se articule con ellos y se configure en nuevos sentidos ?otros?.
Nuevos datos sobre las Quebradas altas del Calchaquí medio, Salta, noroeste de Argentina (NOA). Reproducción local entre los siglos XI a XV
Authors: Williams Verónica 
Published: July 2019

Se ha propuesto para el noroeste de Argentina, entre el 1000 y 1400 AD, un estado de fragmentación política, situaciones de conflicto y la emergencia de jerarquías siendo una de las causas de esta situación los cambios climáticos que ocurrieron en los Andes alrededor del siglo XIII. La información arqueológica de las quebradas altas del valle Calchaquí medio, en la actual provincia de Salta, entre los siglos XI y XVII, nos permiten plantear la hipótesis de la continuidad en la ocupación de estos espacios siguiendo prácticas y lógicas de tiempos prehispánicos, que estuvieron vinculadas a la subsistencia y reproducción social, tales como el manejo estacional y altitudinal agrícola-ganadero por parte de las poblaciones locales. Nuestro objetivo es dar a conocer resultados de las investigaciones en las quebradas altas del valle Calchaquí intentando entender cómo podría haber sido la dinámica poblacional entre los siglos XI y XV a partir de información arqueológica .
Factors associated with keratopathy in captive pinnipeds
Authors: Colitz Carmen M. H. , Saville William J. A. , Walsh Michael T. , Latson Ed 
Published: July 2019

Abstract
OBJECTIVE To identify factors associated with keratopathy in captive pinnipeds and to provide guidance for preventive measures.
ANIMALS 319 captive pinnipeds (229 otariids [sea lions and fur seals], 74 phocids [true seals], and 16 odobenids [walrus]) from 25 facilities.
PROCEDURES Descriptive data collected from questionnaires completed by facilities and from medical records and physical examinations of pinnipeds were compiled and evaluated. Variables were assessed with χ2 tests of homogeneity to determine potential association with keratopathy, and variables with values of P ≤ 0.25 were inserted into the multivariable logistic regression model.
RESULTS Results indicated that variables associated with significantly increased odds of keratopathy in captive pinnipeds included lighter or reflective pool color (OR, 2.11; 95% confidence interval [CI], 1.20 to 3.97), pool water salinity < 29 g/L (OR, 3.48; 95% CI, 1.89 to 6.56), and history of eye disease (OR, 3.30; 95% CI, 1.85 to 5.98), trauma (OR, 3.80; 95% CI, 1.72 to 8.89), and having been tested for leptospirosis (OR, 3.83; 95% CI, 1.54 to 10.26). However, odds of keratopathy decreased with UV index ≤ 6 (OR, 0.39; 95% CI, 0.2 to 0.72) and age < 20 years (OR, 0.32; 95% CI, 0.15 to 0.66).
CONCLUSIONS AND CLINICAL RELEVANCE Findings indicated that odds of keratopathy in pinnipeds could be reduced by maintenance of pool water salinity ≥ 29 g/L and reduction of UV radiation exposure (eg, with adequate shade structures and use of darker, natural colors). Because UV radiation exposure is cumulative, even small attempts to reduce lifetime exposure to it could help control keratopathy in pinnipeds.
Predicting the separation of time scales in a heteroclinic network
Authors: Voit Maximilian , Meyer-Ortmanns Hildegard 
Published: July 2019

Abstract
We consider a heteroclinic network in the framework of winnerless competition, realized by generalized Lotka-Volterra equations. By an appropriate choice of predation rates we impose a structural hierarchy so that the network consists of a heteroclinic cycle of three heteroclinic cycles which connect saddles on the basic level. As we have demonstrated in previous work, the structural hierarchy can induce a hierarchy in time scales such that slow oscillations modulate fast oscillations of species concentrations. Here we derive a Poincaré map to determine analytically the number of revolutions of the trajectory within one heteroclinic cycle on the basic level, before it switches to the heteroclinic connection on the second level. This provides an understanding of which parameters control the separation of time scales and determine the decisions of the trajectory at branching points of this network.
Single-Frequency Ionospheric-Delay Correction from BeiDou & GPS Systems for Northern Hemisphere
Authors: Farah Ashraf 
Published: July 2019

Abstract
The range delay caused by the ionosphere layer is the major current source of error for GNSS users with single-frequency receivers. GNSS advice users to correct this type of error using ionospheric models whose coefficients are sent in their navigation messages. GPS-users use the Klobuchar model to correct this type of error. GPS navigation message contains the model’s eight coefficients which vary on the basis of seasonal ionospheric variations and average solar flux. The correction accuracy of Klobuchar model is about 50% (rms) of the ionospheric range delay. Beidou system calculates and broadcast 8 parameters of Klobuchar model based on continuous monitoring stations. BeiDou system updates the ionospheric coefficients every two hours. GPS-Klobuchar model uses completely different coefficients than BeiDou-Klobuchar model. This research demonstrates a comparison study between the Klobuchar model using the GPS broadcast coefficients and the same model using BeiDou-coefficients. The correction accuracy offered by the two models has been judged using the most accurate International GNSS Service-Global Ionospheric Maps (IGS-GIMs) for three different-latitude stations along northern hemisphere, one station in low-latitude region, the second station is in mid-latitude region and the third station is in high-latiude region to reflect models’ behaviour in different geographic regions. The study was applied over three different months of the year 2017 that each of them reflects a different activity state for the ionosphere layer. The study proves that BeiDou model is able to show the ionosphere’s day-to-day fluctuations while GPS model can’t. It can be concluded that GPS model offers better behaviour than BeiDou model in correcting range delay in low-latitude and high-latitude geographic regions under any activity state for the ionosphere. BeiDou model offers better correction accuracy than GPS model in mid-latitude under any activity state for the ionosphere.
Performance and economic analysis of Markovian Bernoulli feedback queueing system with vacations, waiting server and impatient customers
Authors: Bouchentouf Amina Angelika , Guendouzi Abdelhak , Kandouci Abdeldjebbar 
Published: July 2019

Abstract
This paper concerns the analysis of a Markovian queueing system with Bernoulli feedback, single vacation, waiting server and impatient customers. We suppose that whenever the system is empty the sever waits for a random amount of time before he leaves for a vacation. Moreover, the customer’s impatience timer depends on the states of the server. If the customer’s service has not been completed before the impatience timer expires, the customer leaves the system, and via certain mechanism, impatient customer may be retained in the system. We obtain explicit expressions for the steady-state probabilities of the queueing model, using the probability generating function (PGF). Further, we obtain some important performance measures of the system and formulate a cost model. Finally, an extensive numerical study is illustrated.
Integrals of polylogarithmic functions with negative argument
Authors: Sofo Anthony 
Published: July 2019

Abstract
The connection between polylogarithmic functions and Euler sums is well known. In this paper we explore the representation and many connections between integrals of products of polylogarithmic functions and Euler sums. We shall consider mainly, polylogarithmic functions with negative arguments, thereby producing new results and extending the work of Freitas. Many examples of integrals of products of polylogarithmic functions in terms of Riemann zeta values and Dirichlet values will be given.
Corporate Bankruptcy Prediction in Poland Against the Background of Foreign Experience
Authors: Prusak Błażej 
Published: July 2019

AbstractIn highly developed countries, research in the field of bankruptcy risk prediction has been conducted for many years. For example, in the United States, which can be considered a pioneering country, the first publications appeared in the early twentieth century. In Poland, due to political and economic reasons, the interest in this issue dates back to the early 1990s. For this reason, this publication attempts to answer the following questions: 1) What is the level of advancement of the research into predicting bankruptcies of enterprises in Poland? 2) How does it compare to worldwide trends? Therefore, the main aim of this study is to present and evaluate the scientific achievements of Polish authors in the field of corporate bankruptcy prediction and compare them to global trends. Literature analysis was adopted as the research method and shows that initially in Poland only very simple tools were used to assess the risk of bankruptcy of enterprises. With time, however, advanced methods began to be introduced and new models included non-financial variables. Also, research on the selection of the samples was conducted. Currently, the level of research and applied tools do not differ from those used in highly developed countries.
Vehicles leasing operations in Lagos state, Nigeria
Authors: Solanke Muse Olayiwola , Raji Bashiru Adisa , Alli Taiwo Kareem 
Published: July 2019

Abstract
Vehicle is an important element of transport; and its financing especially in road transport comes in 3 ways; outright purchase, hire purchase and lease. Of all these three methods of road transport financing, leasing has attracted little attention in Nigeria transport research. This study was carried out to examine the development, types and form, operating characteristics and problems of vehicle lease in Lagos State, Nigeria. Aggregate number of vehicle leasing companies in Nigeria from inception to 2018 was obtained from corporate affairs commission (CAC). Four prominent vehicle leasing companies: Cashlink Leasing Plc (CLP), NIKKY Taurus Ltd (NTL), C & I Leasing (CIL) and SAMTL Leasing Ltd (SLL) were purposively selected for the operating characteristics and challenges of the leasing companies. 298 structured questionnaires were administered to the staffs of the selected companies seeking the types and forms of lease and challenges encountered in the course of operation using stratified and simple random samplings techniques. Vehicle leasing started in Nigeria from 1986 with the likes of pine hill leasing, Cashlink leasing, VT leasing in Lagos. Within 1986 and 2018, it has spread to 23 different urban cities and the number has increased to 297 companies in 2018. Operating and finance leases exist in the industry with majority of 91.6% of the companies practice operating lease. The staff strength and fleet size level of the leasing companies varies overtime but positively significant to their operations. However, poor pricing of lease service, inadequate finance of vehicle, default in payment of rental charges and high cost of maintenance minimize leasing service efficiency and effectiveness. It is recommended that government should provide subvention for vehicles acquisition, face-off of racketing vehicles from cites and legislate policy to regulate operational activities (entry and exit) of the companies.
An Enthymematic Account of the Deduction of the Negative Meaning of the Chinese Shenme-based Rhetorical Question Construction
Authors: Dong Chengru , Jin Dawei 
Published: July 2019

Abstract
One controversy in the study of the Chinese shenme ‘what’-based rhetorical question (shenme-RQ for short) is how it takes on a negative interpretation. This paper attempts to apply enthymeme or rhetorical syllogism to the deduction of negative meaning of the shenme-RQ. Triggered by the shenme-RQ, or one of its words or phrases, the hearer extracts the explicit premise, fills in the premise that is implicit either in the context or in her or his encyclopedic knowledge, and deduces the conclusion, the negative meaning of the shenme-RQ. According to what premises are left out, the paper also explores the deduction patterns of the negative meaning of shenme-RQs and proposes a procedure for obtaining the negative interpretation. That said, the negative meaning of the shenme-RQ will be entrenched in the mind of its users and conventionalized in the Mandarin Chinese community via repeated use.
Nonlinguistic Factors that Affect the Degree of Foreign Accent in Second Language Mandarin
Authors: Freeborn Lani , Rogers John 
Published: July 2019

Abstract
Previous research findings have established that a number of nonlinguistic factors can influence the strength of perceived foreign accent in second language (L2) speech. However, the majority of past studies have predominantly considered foreign accent of Indo-European languages, notably English. Therefore, it remains unknown whether the same factors influence foreign accent in other languages, such as Mandarin. This article reports findings from a study on nonlinguistic factors affecting the degree of foreign accent in Mandarin as an L2. Seventy L2 learners of Mandarin Chinese recorded speech samples and completed language background questionnaires. Speech samples were rated by 15 native Mandarin speakers for the degree of foreign accent on a 9-point Likert scale. Stepwise multiple regression analysis resulted in a 3-predictor model of pronunciation accuracy: self-rating of foreign accent, Hànyǔ Shuǐpíng Kǎoshì (HSK) proficiency level, and motivational reasons. Results suggest that (1) foreign accent in L2 Mandarin may not be affected by the same factors as in previous L2 accent studies and (2) the concepts of accentedness and comprehensibility may be more intricately linked in lexical tone languages such as Mandarin, in comparison to nontonal languages. These findings have wider implications for the field of L2 acquisition, which is dominated by studies of L2 English.
But, you see, the problem is …Perception verbs in courtroom talk: Focus onyou see
Authors: Szczyrbak Magdalena 
Published: July 2019

AbstractThis article seeks to contribute to the body of research on the use of perception verbs in interaction and, more specifically, to enhance the understanding of how participants in courtroom proceedings exploityou seeto manage the discourse as it unfolds and to negotiate stance. Against the background of earlier work on vision words in interaction, the study looks at parenthetical and non-parentheticalyou seeto reveal both perceptual and cognitive uses, and to identify their local pragmatic effect. As the analysis indicates, in the data at hand, lexicalyou seeis more readily recruited than non-lexicalyou see, and it is found chiefly in grammatical and declarative questions. At the same time, it is the clause-initialyou seethat visibly brings out the epistemic tensions between the speakers and serves to contest the addressee’s position. The study corroborates the claim thatyou seeis an argumentative marker, whose meaning (and force) depends on its formal properties (position, complementation) and the relationship between the speakers.
Q-Float in West Ulster English and labeling
Authors: Blümel Andreas 
Published: July 2019

AbstractIn this paper I contrast a stranding analysis of Q-float in intermediate A′-positions in West Ulster English with the labeling analysis of successive-cyclic A′-movement and show that the former represents a problem for the latter. If we want to retain the labeling analysis, alternatives to stranding must come forward, some of which I discuss here.
RANCANGAN FASILITAS KERJA PADA PROSES PERAKITAN CONTROLLER DI PT MULTITANAKA SURYATAMA BERDASARKAN PRINSIP ERGONOMI
Authors: Widodo Lamto , Sukania I Wayan , Yota Kevin 
Published: July 2019

PT Multitanaka Suryatama adalah sebuah perusahaan yang bergerak dalam bidang manufaktur plastik. Salah satu proses yang dilakukan di perusahaan ini adalah proses perakitan controller. Berdasarkan analisa kuisioner Nordic Body Map (NBM), proses ini dikerjakan dengan posisi kerja yang menyebabkan keluhan fisik operator. Posisi kerja pada proses ini memiliki tingkat risiko musculoskeletal yang tertinggi berdasarkan analisis Rapid Entire Body Assesment (REBA) yaitu memiliki skor 11. Analisis dengan menggunakan peta tangan kanan dan kiri menunjukkan adanya kegiatan-kegiatan yang tidak efisien dan dapat dieliminasi seperti kegiatan mencari, menganggur, dan menjangkau. Tahap penelitian berikutnya adalah dilakukan analisis keluhan, harapan dan kebutuhan serta kuisioner perancangan fasilitas kerja. Berdasarkan hal tersebut, didapatkan 3 (tiga) buah alternatif desain yang kemudian dipilih dengan menggunakan metode Analytical Hierarchy Process. Alternatif yang terpilih disesuaikan dengan antropometri tubuh pekerja dan dilakukan simulasi dengan menggunakan perangkat lunak CATIA sehingga didapatkan nilai REBA adalah 3 (dapat diterima, risiko rendah). Kemudian hasil rancangan diujudkan dalam bentuk prototype dan dilakukan implementasi. Hasil implementasi menunjukkan keluhan fisik berkurang dari 17 bagian tubuh menjadi 2 bagian tubuh. Skor tertinggi REBA mengalami penurunan menjadi 2 sehingga tingkat risiko rendah. Kegiatan mencari, menganggur dan menjangkau dieliminasi sehingga terjadi penurunan waktu siklus untuk proses perakitan sebesar 14,43%.
Computational Cardiovascular Flow Analysis with the Variational Multiscale Methods
Authors: Takizawa Kenji , Bazilevs Yuri , E. Tezduyar Tayfun , Hsu Ming-Chen 
Published: July 2019

Computational cardiovascular flow analysis can provide valuable information to medical doctors in a wide range of patientspecific cases, including cerebral aneurysms, aortas and heart valves. The computational challenges faced in this class of flow analyses also have a wide range. They include unsteady flows, complex cardiovascular geometries, moving boundaries and interfaces, such as the motion of the heart valve leaflets, contact between moving solid surfaces, such as the contact between the leaflets, and the fluid–structure interaction between the blood and the cardiovascular structure. Many of these challenges have been or are being addressed by the Space–Time Variational Multiscale (ST-VMS) method, Arbitrary Lagrangian–Eulerian VMS (ALE-VMS) method, and the VMS-based Immersogeometric Analysis (IMGA-VMS), which serve as the core computational methods, and the special methods used in combination with them. We provide an overview of the core and special methods and present examples of challenging computations carried out with these methods, including aorta and heart valve flow analyses. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Field Case: Application of Polyamine Based Mud System to Drill Kintom Formation in Sulawesi and Comparison to Conventional KCl-Polymer Mud System
Authors: Setyanto Dominico Alphan , Sudibjo Rachmat , Hamid Abdul 
Published: July 2019

Drilling mud has a vital role in onshore or offshore oil and gas drilling operations with its primary function as the hydrostatic pressure to balance the formation pressure. There are some formations in Indonesia where the drilling hazards are extensive, but the problem that most likely to overcome is the shale/clay swelling. Today there is a water based mud called Polyamine Mud, a Polyamine mud has the advantages over conventional water base mud and also in some functions are as good as the Oil Base Mud. Some companies are still trying to adopt this technology into their drilling projects with various aspects to be considered and are wondering whether it will help them to drill a formation with shale/clay problem characteristics. A field location on the island of Sulawesi has drilled some wells on the Kintom formation using the Polyamine mud for a total depth of about 7,000 ft – 9,000 ft. The drill hole problem was not only the shale/clay swelling, but was also followed by some problems such as differential sticking and partial to total mud losses. The wells have now been drilled successfully and the gas production was above expectation. This paper will discuss a comparison of the Polyamine mud with the conventional mud system such as KCL-Polymer mud by doing some unconventional tests in the laboratory, including inhibition test, dispersion test, accression test, and bulk hardness test. After being tested in the laboratory, the Polyamine 3% mud system has drilled succesfully in some wells.