bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of pigments, modification, and their functionalities
Authors: Sarkodie Bismark , Acheampong Collins , Asinyo Benjamin , Zhang Xun , Tawiah Benjamin 
Published: February 2019

AbstractNovel treatments of pigments with inorganic materials have tremendous industrial and commercial prospects. Specific treatment of pigment has a marked effect on its behavior during application. The treatment allows a broad modification of the surface characteristics of pigment particles which leads to improved functionalities. Surface modification of pigments is achieved via coating, polymerization with modifying reagent, treatment with derivatives or polymers, which alter either the optical, conductivity or dispersibility during processing and application. These and many other distinguishing factors that affect the characteristics of pigments such as the class, crystal structure, particle morphology, particle size, hiding power, pigment volume concentration, surface character, and surface treatment have been reviewed. Various organic pigments such as those from fungus and bacteria, and the various families of pigment types such as metallic pigment, light interference, and diffractive pigments which presents decorative quality such as leafing, nonleafing, pearlscent, and Fabry‐Perot effects on substrates have also been reviewed in addition to those from inorganic sources with emphasis on the structure and physiochemical modifications using metal and nonmetal Ions.
Integrating Bacterial ChIP‐seq and RNA‐seq Data With SnakeChunks
Authors: Rioualen Claire , Charbonnier‐Khamvongsa Lucie , Collado‐Vides Julio , van Helden Jacques 
Published: February 2019

AbstractNext‐generation sequencing (NGS) is becoming a routine approach in most domains of the life sciences. To ensure reproducibility of results, there is a crucial need to improve the automation of NGS data processing and enable forthcoming studies relying on big datasets. Although user‐friendly interfaces now exist, there remains a strong need for accessible solutions that allow experimental biologists to analyze and explore their results in an autonomous and flexible way. The protocols here describe a modular system that enable a user to compose and fine‐tune workflows based on SnakeChunks, a library of rules for the Snakemake workflow engine. They are illustrated using a study combining ChIP‐seq and RNA‐seq to identify target genes of the global transcription factor FNR in Escherichia coli, which has the advantage that results can be compared with the most up‐to‐date collection of existing knowledge about transcriptional regulation in this model organism, extracted from the RegulonDB database. © 2019 by John Wiley & Sons, Inc.
A Phase 3, Randomized, Placebo‐Controlled Evaluation of the Safety of Intravenous Meloxicam Following Major Surgery
Authors: Bergese Sergio D. , Melson Timothy I. , Candiotti Keith A. , Ayad Sabry S. , Mack Randall J. , McCallum Stewart W. , Du Wei , Gomez Alexis , Marcet Jorge E. 
Published: February 2019

AbstractAn intravenous (IV) formulation of meloxicam is being studied for moderate to severe pain management. This phase 3, randomized, multicenter, double‐blind, placebo‐controlled trial evaluated the safety of once‐daily meloxicam IV 30 mg in subjects following major elective surgery. Eligible subjects were randomized (3:1) to receive meloxicam IV 30 mg or placebo administered once daily. Safety was evaluated via adverse events, clinical laboratory tests, vital signs, wound healing, and opioid consumption. The incidence of adverse events was similar between meloxicam IV– and placebo‐treated subjects (63.0% versus 65.0%). Investigators assessed most adverse events as mild or moderate in intensity and unrelated to treatment. Adverse events of interest (injection‐site reactions, bleeding, cardiovascular, hepatic, renal, thrombotic, and wound‐healing events) were similar between groups. Over the treatment period, meloxicam IV was associated with a 23.6% (P = .0531) reduction in total opioid use (9.2 mg morphine equivalent) compared to placebo‐treated subjects. The results suggest that meloxicam IV had a safety profile similar to that of placebo with respect to numbers and frequencies of adverse events and reduced opioid consumption in subjects with moderate to severe postoperative pain following major elective surgery.
Online combinatorial based mechanism for MEC network resource allocation
Authors: Wu Xiaogang , Jiang Weiheng , Zhang Yu , Yu Wanxin 
Published: February 2019

SummaryIn this paper, the resource allocation problem for mobile edge computing (MEC) network is discussed. We focus on the design of online resource allocation strategy by considering the time‐varying demands of the combinatorial resources for the mobile users. To handle this issue, at first, a time splitting‐based online allocation mechanism is introduced. Then, for a given resource allocation period of the time splitting, a combinatorial auction mechanism for the combination resources allocation is proposed. We further prove that the proposed combinatorial auction is both individual rational and incentive‐compatible, and which can bring a higher revenue to the service provider. In order to verify the performance of the proposed mechanism, a variable‐relaxed‐based performance‐bound algorithm and a greedy optimization‐based suboptimal algorithm are presented for comparison purpose. Finally, the performance of these proposed algorithms are testified by numerical simulations, which confirm the analysis results.
Recent drought and tree mortality effects on the avian community in southern Sierra Nevada: a glimpse of the future?
Authors: Roberts L. Jay , Burnett Ryan , Tietz James , Veloz Sam 
Published: February 2019

AbstractBirds respond rapidly to changes in both habitat and climate conditions and thus are good indicators of the ecological effects of a changing climate, which may include warmer temperatures, changing habitat conditions, and increased frequency and magnitude of extreme events like drought. We investigated how a widespread tree mortality event concurrent with a severe drought influenced the avian community of the Sierra Nevada mountain range in California. We assessed and compared the separate effects of climate stresses and altered habitat conditions on the avian community and used this information to evaluate the changes that are likely to occur in the near future. We built tree mortality maps from freely available Landsat imagery with Google Earth Engine. We analyzed avian point counts from 2010 to 2016 in the southern Sierra Nevada, to model temperature, water deficit, and tree mortality effects on the abundances of 45 bird species, and then used these models to project abundances into the future based on three climate projections. A large portion of the avian community, 47%, had a positive relationship with temperature increase, compared to 20% that responded negatively. More species (36%) declined with drier conditions than increased (29%). More species declined in response to high tree mortality (36%) than increased (9%). A preponderance of species adapted to colder temperatures (higher elevation) had negative responses to high tree mortality and water deficit, but positive responses to increasing temperature. We projected the highest total bird abundances in the future under the warmest climate scenario that we considered, but habitat modification (e.g., tree mortality) and water deficit could offset the positive influence of temperature for many species. As other studies have shown, climate warming may lead to substantial but idiosyncratic effects on wildlife species that could result in community composition shifts. We conclude that future climate conditions may not have a universally negative effect on biodiversity in the Sierra Nevada, but probable vegetation changes and increased likelihood of extreme events such as drought should be incorporated into climate‐smart forest and wildlife management decisions.
Genetic diversity among perennial wild rice Oryza rufipogon Griff., in the Mekong Delta
Authors: Lam Dinh T. , Buu Bui C. , Lang Nguyen T. , Toriyama Kinya , Nakamura Ikuo , Ishikawa Ryuji 
Published: February 2019

AbstractOryza rufipogon Griff. is a perennial species of wild rice widely distributed along the channels and rivers of the Mekong Delta, Vietnam. This study attempted to find centers of diversity among wild rice populations in this area and their inter‐relationships. The highest genetic diversity was found in the Dong Thap population and the lowest in the Can Tho population. Maternal diversity evaluated using chloroplast INDELs detected ten plastid types, five of which were novel relative to other Asian countries. The mitochondrial genome suggested two unique deletions. One 699‐bp deletion via short tandem repeats was accompanied by another deletion including orf153. All accessions carrying the mitochondrial type were found in a particular plastid type. This unique maternal lineage was confined to specific channels where it showed vigorous vegetative growth in comparison to upstream areas where various maternal lineages and maximum genetic diversity occurred. This area along the Mekong Delta is a center of not only nuclear but also maternal diversity.
Vitamin D deficiency in patients with diastolic dysfunction or heart failure with preserved ejection fraction
Authors: Nolte Kathleen , Herrmann‐Lingen Christoph , Platschek Lars , Holzendorf Volker , Pilz Stefan , Tomaschitz Andreas , Düngen Hans‐Dirk , Angermann Christiane E. , Hasenfuß Gerd , Pieske Burkert , Wachter Rolf , Edelmann Frank 
Published: February 2019

AbstractAimsVitamin D deficiency is prevalent in heart failure (HF), but its relevance in early stages of heart failure with preserved ejection fraction (HFpEF) is unknown. We tested the association of 25‐hydroxyvitamin D [25(OH)D] serum levels with mortality, hospitalizations, cardiovascular risk factors, and echocardiographic parameters in patients with asymptomatic diastolic dysfunction (DD) or newly diagnosed HFpEF.Methods and resultsWe measured 25(OH)D serum levels in outpatients with risk factors for DD or history of HF derived from the DIAST‐CHF study. Participants were comprehensively phenotyped including physical examination, echocardiography, and 6 min walk test and were followed up to 5 years. Quality of life was evaluated by the Short Form 36 (SF‐36) questionnaire. We included 787 patients with available 25(OH)D levels. Median 25(OH)D levels were 13.1 ng/mL, mean E/e′ medial was 13.2, and mean left ventricular ejection fraction was 59.1%. Only 9% (n = 73) showed a left ventricular ejection fraction <50%. Fifteen per cent (n = 119) of the recruited participants had symptomatic HFpEF. At baseline, participants with 25(OH)D levels in the lowest tertile (≤10.9 ng/L; n = 263) were older, more often symptomatic (oedema and fatigue, all P ≤ 0.002) and had worse cardiac [higher N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and left atrial volume index, both P ≤ 0.023], renal (lower glomerular filtration rate, P = 0.012), metabolic (higher uric acid levels, P < 0.001), and functional (reduced exercise capacity, 6 min walk distance, and SF‐36 physical functioning score, all P < 0.001) parameters. Increased NT‐proBNP, uric acid, and left atrial volume index and decreased SF‐36 physical functioning scores were independently associated with lower 25(OH)D levels. There was a higher risk for lower 25(OH)D levels in association with HF, DD, and atrial fibrillation (all P ≤ 0.004), which remained significant after adjusting for age. Lower 25(OH)D levels (per 10 ng/mL decrease) tended to be associated with higher 5 year mortality, P = 0.05, hazard ratio (HR) 1.55 [1.00; 2.42]. Furthermore, lower 25(OH)D levels (per 10 ng/mL decrease) were related to an increased rate of cardiovascular hospitalizations, P = 0.023, HR = 1.74 [1.08; 2.80], and remained significant after adjusting for age, P = 0.046, HR = 1.63 [1.01; 2.64], baseline NT‐proBNP, P = 0.048, HR = 1.62 [1.01; 2.61], and other selected baseline characteristics and co‐morbidities, P = 0.043, HR = 3.60 [1.04; 12.43].ConclusionsLower 25(OH)D levels were associated with reduced functional capacity in patients with DD or HFpEF and were significantly predictive for an increased rate of cardiovascular hospitalizations, also after adjusting for age, NT‐proBNP, and selected baseline characteristics and co‐morbidities.
CCL21‐expression and accumulation of CCR7+ NK cells in livers of patients with primary sclerosing cholangitis
Authors: Langeneckert Annika E. , Lunemann Sebastian , Martrus Glòria , Salzberger Wilhelm , Hess Leonard U. , Ziegler Annerose E. , Poch Tobias , Ravichandran Gevitha , Matschl Urte , Bosse Jens B. , Tiegs Gisa , Fischer Lutz , Koch Martina , Herkel Johannes , Oldhafer Karl J. , Schramm Christoph , Altfeld Marcus 
Published: February 2019

AbstractThe pathogenesis of primary sclerosing cholangitis (PSC), an autoimmune liver disease, remains unknown. The aim of this study was to characterize peripheral blood and intrahepatic NK cells from patients with PSC. Peripheral blood samples from patients with PSC, other autoimmune liver diseases, and from healthy control individuals were used, as well as liver tissues from PSC patients undergoing liver transplantation. Multiparameter flow cytometry showed that peripheral blood NK cells from PSC patients were significantly enriched for CCR7+ and CXCR3+ cells, and CCR7+ but not CXCR3+ cells were also significantly increased within intrahepatic NK cells. PSC patients undergoing liver transplantation furthermore had significantly higher plasma levels of the CCR7‐ligand CCL21, and the CXCR3‐ligands CXCL10 and CXCL11, and significantly higher levels of CCL21, but not CXCL10, were detected in liver tissues. CCR7+ and CXCR3+ NK cells from PSC patients exhibited significantly higher functional capacity in peripheral blood, but not liver tissues, consistent with chronic activation of these NK cells in the inflamed liver. These data show that PSC is characterized by intrahepatic CCL21 expression and accumulation of CCR7+ NK cells in the inflamed liver tissue.
Performance improvement of plasmonic sensors using a combination of AC electrokinetic effects for (bio)target capture
Authors: Avenas Quentin , Moreau Julien , Costella Marion , Maalaoui Arbi , Souifi Abdelkader , Charette Paul , Marchalot Julien , Frénéa‐Robin Marie , Canva Michael 
Published: February 2019

AbstractAnalytes concentration techniques are being developed with the appealing expectation to boost the performance of biosensors. One promising method lies in the use of electrokinetic forces. We present hereafter a new design for a microstructured plasmonic sensor which is obtained by conventional microfabrication techniques, and which can easily be adapted on a classical surface plasmon resonance imaging (SPRI) system without further significant modification. Dielectrophoretic trapping and electro‐osmotic displacement of the targets in the scanned fluid are performed through interdigitated 200 μm wide gold electrodes that also act as the SPR‐sensing substrate. We demonstrate the efficiency of our device's collection capabilities for objects of different sizes (200 nm and 1 μm PS beads, as well as 5–10 μm yeast cells). SPRI is relevant for the spatial analysis of the mass accumulation at the electrode surface. We demonstrate that our device overcomes the diffusion limit encountered in classical SPR sensors thanks to rapid collection capabilities (<1 min) and we show a consequent improvement of the detection limit, by a factor >300. This study of an original device combining SPRI and electrokinetic forces paves the way to the development of fully integrated active plasmonic sensors with direct applications in life sciences, electrochemistry, environmental monitoring and agri‐food industry.
Deep‐DRX: A framework for deep learning–based discontinuous reception in 5G wireless networks
Authors: Memon Mudasar Latif , Maheshwari Mukesh Kumar , Shin Dong Ryeol , Roy Abhishek , Saxena Navrati 
Published: February 2019

AbstractThe tremendous advancement in various types of mobile devices with distinct services demands emerging 5G networks to deal with different kinds of traffic. The high data rates along with beam searching operation in 5G increase user equipment (UE) energy expenses. Discontinuous reception (DRX) is used in long‐term evolution network to save the power of UE. The DRX conserves the energy at the cost of increased latency. On the other hand, long short‐term memory (LSTM), a deep neural network, has shown incredible results in learning time‐varying sequences from data sets. In this article, we propose a novel idea to train LSTM network for prediction of next packet arrival time based on real wireless traffic trace (dataset). Then, we use the trained LSTM model to predict dynamic sleep time in DRX for 5G networks. Our proposed algorithm, deep learning–based DRX (Deep‐DRX) is able to make dynamic sleep cycle in 5G communications. Deep‐DRX achieves 10% and 30% of power saving with a mean delay of 1.006 ms and 1.05 ms for Trace 1 and Trace 2, respectively.
Roles of electrical stimulation in promoting osteogenic differentiation of BMSCs on conductive fibers
Authors: Jing Wei , Huang Yiqian , Wei Pengfei , Cai Qing , Yang Xiaoping , Zhong Weihong 
Published: February 2019

AbstractThe strategy of using conductive materials in regenerating bone defects is attractive, benefiting from the bioelectricity feature of natural bone tissues. Thereby, POP conductive fibers were fabricated by coating polypyrrole (PPY) onto electrospun poly(l‐lactide) (PLLA) fibers, and their potentials in promoting osteogenic differentiation of bone mesenchymal stromal cells (BMSCs) were investigated. Different from the smooth‐surfaced PLLA fibers, POP fibers were rough‐surfaced and favorable for protein adsorption and mineralization nucleation. When electrical stimulation (ES) was applied, the surface charges on the conductive POP fibers further promoted the protein adsorption and the mineral deposition, while the non‐conductive PLLA fibers displayed no such promotion. When BMSCs were cultured on these fibers, strong cell viability was detected, indicating their good biocompatibility and cell affinity. In osteogenic differentiation studies, BMSCs demonstrated the strongest ability in differentiating toward osteoblasts when they were cultured on the POP fibers under ES, followed by the case without ES. In comparison with the conductive POP fibers, the non‐conductive PLLA fibers displayed significantly weaker ability in inducing the osteogenic differentiation of BMSCs with ES being applied or not. Alongside the differentiation, both the calcium deposition on BMSC/material complexes and the intracellular Ca2+ concentration were identified the most abundant when BMSCs grew on the POP fibers under ES. These findings suggested that the surface charges of conductive fibers played roles in regulating protein adsorption, ion migration and nucleation, particularly under ES, which contributed much to the increased intracellular Ca2+ ions, and thus accelerated the osteogenic differentiation of the seeded cells. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.
Polylactic‐co‐glycolic acid microspheres added to fixative cements and its role on bone infected architecture
Authors: Ibarra Blanca , García‐García Joaquin , Azuara Galo , Vázquez‐Lasa Blanca , Ortega Miguel A. , Asúnsolo Ángel , San Román Julio , Buján Julia , García‐Honduvilla Natalio , De la Torre Basilio 
Published: February 2019

AbstractJoint prostheses are an essential element to improve quality of life. However, prostheses may fail due to several factors, including the most frequent cause, Staphylococcus aureus infection. The identification of new fixing bone cements with less reactivity on bone tissue and an adequate response to infection remains a primary challenge. The aim of this study is to evaluate the response of bone tissue in rabbits after introduction of a hydroxyapatite‐coated titanium rod with a commercial fixative cement (Palacos®) compared to a modified experimental cement (EC) containing polylactic‐co‐glycolic acid (PLGA) microspheres in the presence or absence of contaminating germs. This study used 20 New Zealand rabbits which were divided into four groups (n = 5) depending on the presence or absence of S. aureus and the use of commercial (Palacos®) or EC. A histological method, based on bone architecture damage, was proposed to evaluate from 1 to 9 the histological results and the response of the infected tissue. The macrophage response was also evaluated using monoclonal antibody RAM‐11. The study showed better bone conservation with the use of EC with PLGA microspheres against the Palacos® commercial cement, including the noncontaminated and contaminated groups. © 2019 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2517–2526, 2019.
A meta‐analysis of the relationship between foot local characteristics and major lower extremity amputation in diabetic foot patients
Authors: Wang Ning , Yang Bo‐Hua , Wang Gang , Gao Yu , Cao Xin , Zhang Xiao‐Fu , Yan Cheng‐Cheng , Lian Xiao‐Tong , Liu Bo‐Hong , Ju Shang 
Published: February 2019

AbstractObjectiveTo clarify and quantify risk factors among local characteristics of the foot for major amputation in diabetic foot patients.MethodsArticles published before January 2018 on PubMed and Embase were conducted observational studies about risk factors for major amputation in patients with diabetic foot were retrieved and systematically reviewed by using Stata 12.0 statistical software.ResultsA total of 4668 major amputees and 65 831 controls were reported in 18 observational studies. Across the studies, the overall odds ratios (ORs) and 95% confidence intervals (CIs) of significant risk factors are ulcer reaching bone (OR, 11.796; 95% CI, 6.905‐20.152), gangrene (OR, 6.487; 95% CI, 4.088‐10.293), hindfoot position (OR, 3.913; 95% CI, 2.254‐6.795), decreased ankle‐brachial index (ABI) (OR, 2.522; 95% CI, 1.805‐3.523), infection (OR, 2.516; 95% CI, 1.708‐3.706), peripheral arterial disease (PAD) (OR, 2.114; 95% CI, 1.326‐3.372). While there is no significant difference in the size of the ulcer, neuropathy, Charcot foot, osteomyelitis and intermittent claudication (OR, 1.15; 95% CI, 0.85‐1.54).ConclusionFactors among local characteristics of the foot associated with major amputation in patients with diabetic foot are the ulcer reaching bone, gangrene, hindfoot position, decreased ABI, infection, and PAD, a negative risk factor for the risk of amputation. Further studies are required to provide more details of foot local characteristics.