bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual uniqueness of connectivity gradients is driven by the complexity of the embedded networks and their dispersion
Authors: Serhan Yvonne , Darawshy Shaymaa , Wei Wei , Margulies Daniel S. , Nenning Karl-Heinz , Ovadia-Caro Smadar 
Published: December 2024

AbstractConnectivity gradients are widely used to characterize meaningful principles of functional brain organization in health and disease. However, the degree of individual uniqueness and shared common principles is not yet fully understood. Here, we leveraged the Hangzhou test-retest dataset, comprising repeated resting-state fMRI scans over the span of one month, to investigate the balance between individual variation and shared patterns of brain organization. We quantified the short- and long-term stability for the first three connectivity gradients and used connectome fingerprinting to establish the associated individual identification rate. We found that all three connectivity gradients are highly correlated over both short and long time intervals, demonstrating connectome fingerprinting utility. Individual uniqueness was dictated by the complexity of the networks such that heteromodal networks had higher connectome fingerprinting rates than unimodal networks. Importantly, the dispersion of the gradient coefficients associated with canonical functional networks was correlated with identification rates, irrespective of the position along the gradients. Beyond individual uniqueness, between subject similarity was high along the first connectivity gradient, which captures the dissociation between unimodal and heteromodal cortices, and the second connectivity gradient, which differentiates sensory cortices. Our results support the usage of connectivity gradients for the purposes of both group comparisons and prediction of individual behaviours. Our work adds to existing knowledge on the shared versus unique organizational principles and offers insights into the importance of network dispersion to the individual uniqueness it carries.
No pains no gains: understanding the impacts of physician efforts in online reviews on outpatient appointment
Authors: Wu Pengkun , Wang Liuan , Jiang Jiuan , Yu Li 
Published: December 2024

PurposeThis study aims to investigate the impact of physician efforts in online reviews on outpatient appointments, while also examining the moderating effect of physician title.Design/methodology/approachThis study employs the heuristic-systematic model (HSM) to analyze the impact of physician efforts on outpatient appointments. Subsequently, a fixed effect model is employed to examine the research model using an 89-week panel dataset (from April 16, 2018 to December 29, 2019) comprising appointment and online review information pertaining to 8,157 physicians from a prominent online health community in China.FindingsThe findings suggest that physicians with lower professional titles exhibit a significantly higher inclination to enhance heuristic information (e.g. attracting helpful votes) compared to those with higher professional title. All physicians can enhance their outpatient appointments by dedicating efforts towards improving systematic review information, but physician title would weaken the relationship. Moreover, the effect of increasing review volume is considerably more substantial than that of increasing review length, which also surpasses the influence of providing managerial response.Originality/valueUnlike previous studies that primarily focus on patients’ perspectives, this paper represents one of the pioneering effects to examine physicians’ engagement in online reviews.
Determinants of healthcare workers' job retention during the global health crisis: insights from a national survey in Canada
Authors: Habibov Nazim , Auchynnikava Alena , Lyu Yunhong 
Published: December 2024

PurposeThe purpose of this study is to investigate the determinants of job retention intention among healthcare workers (HCWs) in Canada during the COVID-19 pandemic.Design/methodology/approachData are from a large nationally representative cross-sectional survey conducted by the Canadian National Statistics Agency. Ordered logistic regression is estimated to find an association between job retention and its main determinants as gleaned from the literature while controlling for a wide range of pertinent covariates. Odds and standardized odds are reported and discussed.FindingsThe results suggest that worsening working conditions, changes in health and well-being and lack of organizational support weaken intentions regarding job retention. Being employed rather than self-employed and working as a nurse also weakens job retention.Originality/valueThis is the first research on the determinants of intentions regarding job retention in Canada using nationally representative data. It allows us to test and confirm the results of previous studies on a large sample of Canadian HCWs. The paper also discusses the implications of the findings for health management and administration.
Linking leader boundary spanning to task performance and its boundary conditions: a conservation of resources perspective
Authors: Kim Seckyoung Loretta , Mah Sunghyuck , Yoon Seoin , Yun Seokhwa 
Published: December 2024

PurposeDrawing on conservation of resources (COR) theory, this research aims to advance the current understanding of leader boundary spanning by examining its effect on task performance, psychological mechanism and boundary conditions.Design/methodology/approachThe empirical data were gathered by a paper-and-pencil survey from 155 employee-supervisor dyads working in various industries.FindingsOur results indicated that leader boundary spanning is positively related to task performance, mediated by employees’ enhanced self-efficacy. Moreover, the results indicated that the positive effect of leader boundary spanning on task performance via enhanced self-efficacy is strengthened when the level of abusive supervision is low or when the level of an employee’s emotional exhaustion is high.Practical implicationsOrganizations should find a way to facilitate leaders to engage in boundary spanning behaviors since a leader’s boundary spanning behavior enhances task performance through employee’s self-efficacy. Additionally, it is crucial to establish policies and provide training sessions to reduce the occurrence of abusive supervision in the workplace.Originality/valueThis study gives insights into the current literature by uncovering whether, how and under what circumstances boundary spanning leaders exert influences on task performance via employees’ self-efficacy. Our results showed that the positive effect of leader boundary spanning is likely to be strengthened when boundary spanners do not abuse their employees or when employees are in need of additional resources.
Gut Microbiota and Metabolite Profiles Associated With Functional Constipation Severity
Authors: Wang Jiwei , He Jixin , Liu Dandan , Zhang Tao , Wu Yin , Xie Ming 
Published: December 2024

AbstractFunctional constipation (FC) is a common digestive disorder that affects patients' quality of life and is closely associated with intestinal tumors. This study used a cross‐sectional design to assess the changes of intestinal flora and metabolites in different severities of FC patients through 16S rRNA sequencing and metabolomics analysis. Results showed that patients with severe FC had significantly higher clinical and anxiety scores compared to those in the mild and moderate groups. The species richness of intestinal microorganisms in the severe FC group was also significantly higher, and obvious differences in the flora composition existed. Specifically, the Bacteroidota was more abundant in the severe FC group, which was a characteristic feature distinguishing severe FC. Metabolomic analyses also revealed metabolite differences among patients with mild‐to‐moderate and severe FC, with the severe FC group showing increased enrichment in L‐isoleucine biosynthesis and glycolysis metabolic pathways. The short‐chain fatty acid–targeted metabolome suggested that a decrease in butyric acid might be related to worsening constipation. This study suggests that specific flora and metabolic pathways could serve as potential diagnostic and therapeutic targets, thereby contributing to the development of new diagnostic and therapeutic approaches to improve the quality of life and therapeutic outcomes for FC patients.
RpoB H481Y Rifampicin Resistance Mutation‐Associated Oxidative Stress Sensitivity Reduces the Virulence of Staphylococcus aureus
Authors: Kano Tomonori , Ishikawa Kazuya , Imai Lina , Furuta Kazuyuki , Kaito Chikara 
Published: December 2024

ABSTRACTIn this study, we have established a Staphylococcus aureus RpoB H481Y mutant strain and demonstrated that it is sensitive to menadione or hydrogen peroxide‐induced oxidative stress and exhibits reduced virulence against a silkworm infection model. Furthermore, the reduced virulence of the RpoB H481Y mutant was abrogated in the presence of N‐acetylcysteine, a reactive oxygen species scavenger. These results suggest that oxidative stress sensitivity caused by the RpoB H481Y rifampicin resistance mutation attenuates the virulence of S. aureus.
Industry Image Perceptions and Organizational Attractiveness: Results of an International Survey
Authors: Davies Samuel , Nguyen Thanh , Stoermer Sebastian , Froese Fabian Jintae , Budhwar Pawan 
Published: December 2024

ABSTRACTExtending the research on corporate brand image and recruitment, this study investigates the influence of industry image on organizational attractiveness in a cross–national context. Drawing from signaling theory and the application of the instrumental‐symbolic image framework, we apply an experimental vignette design in the renewable energy industry (REI) and the oil and gas exploration and production industry (OGI) with potential job applicants in France, Germany, and the United Kingdom. We conceptualize national context as collective signaling environments. Results from 550 respondents indicate that the REI and OGI differ in most of the instrumental and symbolic image dimensions. The instrumental image dimension of pay and the three symbolic image dimensions of sincerity, innovativeness, and prestige predict organizational attractiveness. Moreover, sincerity, innovativeness, and prestige carry a mediating effect in the link between industry affiliation and organizational attractiveness. Findings also demonstrate that image perceptions of the REI and OGI vary across countries such that the already more favorable image perceptions regarding the REI are for the most part even more pronounced in France. Implications for theory and tailored recommendations for practice are provided.
Long‐term quality of life in patients with bladder cancer following radical cystectomy
Authors: Akdemir Emine , Stuiver Martijn M. , van de Kamp Maaike W. , der Hulst Jolanda Bloos ‐ van , Mertens Laura S. , Hendricksen Kees , van Harten Wim H. , May Anne M. , Sweegers Maike G. 
Published: December 2024

ObjectivesTo investigate changes in quality of life (QoL) up to 8 years after radical cystectomy (RC) and compare QoL after RC with a gender‐ and age‐matched Dutch normative population. Furthermore, we aimed to identify patient characteristics associated with QoL and QoL trajectories after RC.Patients and MethodsPatients with bladder cancer were invited to complete QoL questionnaires at 3‐month intervals in the first year and yearly thereafter. Follow‐up data were available for a maximum of 8 years. We used linear mixed‐effect models to investigate changes in QoL subscales (physical functioning [PF], emotional functioning [EF], and QoL summary score [QoL‐sum]) over time, and to identify potential demographic and clinical correlates of QoL and QoL trajectories (i.e., interaction with time).ResultsData from 278 patients was included. Post‐RC EF scores increased from 83.7 (95% confidence interval [CI] 81.7–85.6) to levels comparable to the normative population (90.1) 8 years after RC. PF (post‐RC: 82.4, 95% CI 78.5–86.3) and QoL‐sum (post‐RC: 88.2, 95% CI 85.2–91.2) remained lower compared to the normative population (88.9 and 91.4, respectively) 8 years after RC. Compared to patients with an American Society of Anesthesiologists (ASA) score of 1 at diagnosis, those with ASA score 2 or ASA score 3 had significant lower post‐RC PF (mean difference (MD) = −8 and −22, respectively; P < 0.001), EF (MD = −1 and −11; P = 0.5 and P < 0.01) and QoL‐sum (MD = −2 and −9; P = 0.2 and P < 0.01). In addition, patients with a higher ASA score had a worse QoL‐sum trajectory (Pinteraction = 0.01). Older patients had a worse PF trajectory (Pinteraction < 0.01) but higher post‐RC EF (P < 0.01).ConclusionsDirectly after RC, patients have lower PF, EF and QoL‐sum, compared to a normative population. Notably, EF recovers to normative levels over a period of 8 years after RC. Clinicians are encouraged to administer supportive care interventions to enhance the QoL for patients undergoing RC, especially targeting older patients and those with higher ASA scores.
Systematic drug screening and target analysis identify digitoxin as a potential therapy for uveal melanoma
Authors: Liu Huilin , Huang Chao , Liu Zhenni , Li Yuhan , Zhu Yanan , Gao Min , Chen Jing , Zhang Hui , Xiao Zhengtao , Zhao Wei 
Published: December 2024

Background and PurposeCardiac glycosides (CGs), traditionally prescribed for heart failure and arrhythmias, show anticancer potential. However, their mechanisms for preferential inhibition of tumour tissue and constituent malignant cells are not fully elucidated. This study aims to elucidate the therapeutic benefits of CGs in targeting specific tumours and dissect their multi‐targeting mechanisms that confer their cytotoxicity against malignant cells.Experimental ApproachWe designed an integrated workflow to identify therapeutic CGs with high toxicity to certain cancers, investigating their multi‐target effects, assessing their toxicity to malignant cells and analysing the prognostic relevance of CGs' target genes. The computational findings were confirmed through gene knockdown, cell viability assays, reactive oxygen species (ROS) measurements and so forth.Key ResultsCGs modulate multiple genes crucial for ion homeostasis, oxidative stress and apoptosis, with a particularly strong inhibitory effects on uveal melanoma (UVM). Notably, digitoxin suppresses UVM cell proliferation and induces ROS levels by simultaneously targeting STAT3 and KLF5. Single‐cell transcriptomic analysis revealed that malignant cells are likely more vulnerable to CGs due to their higher expression of CG target genes compared with surrounding cells in the UVM microenvironment.Conclusions and ImplicationsGiven UVM's limited options, our study highlights the potential of digitoxin as a promising novel therapeutic agent for this aggressive and rare ocular cancer. Our comprehensive approach is effective in identifying the potent, cancer‐specific therapeutic agents from herbal plants.
Enhancing logistics through a vehicle routing problem with deliveries, pickups, and backhauls
Authors: Santos Maria João , Jorge Diana , Bonomi Valentina , Ramos Tânia , Póvoa Ana 
Published: December 2024

AbstractToday, logistics activities are driven by the pressing need to simultaneously increase efficiency, reduce costs, and promote sustainability. In our research, we tackle this challenge by adapting a general vehicle routing problem with deliveries and pickups to accommodate different types of customers. Customers requiring both delivery and pickup services are mandatory, while those needing only a pickup service (backhaul customers) are optional and are only visited if profitable. A mixed‐integer linear programming model is formulated to minimize fuel consumption. This model can address various scenarios, such as allowing mandatory customers to be served with combined or separate delivery or pickup visits, and visiting optional customers either during or only after mandatory customer visits. An adaptive large neighborhood search is developed to solve instances adapted from the literature as well as to solve a real‐case study of a beverage distributor. The results show the effectiveness of our approach, demonstrating the potential to utilize the available capacity on vehicles returning to the depot to create profitable and environmentally friendly routes, and so enhancing efficient, cost‐effective, and sustainable logistics activities.
Evaluating performance and quality of a fast multi‐contrast scan in routine brain MRI
Authors: Milshteyn Eugene , Griffin Harry , Chang Yi Shuen , Shaikh Ibraheem , Sprenger Tim , Skare Stefan , Maclellan Christopher J. , Soman Salil 
Published: December 2024

AbstractBackground and PurposeNeuromix is a fast, motion robust multi‐contrast sequence capable of providing all diagnostic contrasts in ∼3.5 minutes. However, more evaluation is needed across the various contrasts compared to gold standard, optimized sequences routinely used in the clinic. The goal of this study was to prospectively determine how NeuroMix performs in the clinical setting compared to routine clinical MRI.MethodsNeuroMix and routine clinical MRI sequences were acquired on a 3 Tesla clinical scanner for 39 patients clinically indicated for brain MRI. Three radiologists were asked to assess the diagnostic confidence of NeuroMix compared to the routine MRI using a series of questions. Signal‐to‐noise and contrast‐to‐noise ratios (SNR and CNR) were assessed for NeuroMix. Fleiss’ free‐marginal multirater kappa was calculated for the qualitative assessment performed by the radiologists.ResultsRadiologists were comfortable substituting or reading some of the NeuroMix sequences in place of the corresponding conventional sequence for some contrasts, including diffusion‐weighted imaging, single‐shot T2, and susceptibility‐weighted imaging. The image quality, SNR, and CNR allowed the radiologists to visualize anatomy and pathology on NeuroMix images. There was no significant difference between coefficient of variation for the apparent diffusion coefficient maps (p = .084).ConclusionsAnalysis revealed both positives and some pitfalls of NeuroMix. However, these results indicate Neuromix as having the capability to be a backup sequence in case artifacts are present in routine sequences, or potentially a replacement for some contrasts altogether.
Associations between caregiver‐adolescent emodiversity and internalizing symptoms
Authors: Lougheed Jessica P. , Loveridge Colin F. , Keskin Gizem , Sin Nancy L. 
Published: December 2024

AbstractRelationships between adolescents and primary caregivers play an important role in the development of internalizing (depressive and anxious) symptoms. We examined associations among caregiver‐adolescent emotions and their emodiversity (their breadth and frequency) with adolescents' and caregivers' internalizing symptoms. A total of 181 adolescents (aged 13–17 years old) and their primary caregivers participated in a 14‐day daily diary study between 2022 and 2023 where they reported their emotions at the end of each day. We used actor‐partner interdependence models to examine whether positive and negative emotions and their emodiversity predicted each individual's and their family member's internalizing symptoms. Primary results concentrated on the actor effects of adolescents' and caregivers' mean levels of positive and negative emotions and their own internalizing symptoms. Greater negative emotion and lower positive emotion were associated with greater internalizing symptoms, for both caregivers and adolescents. Caregivers who showed greater positive emodiversity also showed greater internalizing symptoms. In contrast, relatively few partner effects were observed. Our findings point to the need for more research on the role of interpersonal emotions in daily life as they relate to internalizing symptoms. Although our sample captured diversity in ethnicity, results may not generalize across levels of socioeconomic status, gender identity, and caregiver education.
Emotional reactivity mediates and moderates the longitudinal associations between mothers' depressive symptoms and behavioral problems in youth
Authors: Ji Huayu , Wang Yiji 
Published: December 2024

AbstractDespite the well‐established link between mothers' depressive symptoms and youth behavioral problems, it remains unclear whether the mechanism by which mothers' depressive symptoms promote behavioral problems may also be related to individual differences in this relation. Following the three‐variable system integrating mediation and moderation, this study used an integrative model to simultaneously examine the mediating and moderating role of emotional reactivity in the longitudinal associations between maternal depressive symptoms and internalizing and externalizing problems in youth. Participants were 1060 youth and their mothers from the NICHD Study of Early Child Care and Youth Development (49.7% boys, 81.6% white). Mothers reported their own depressive symptoms at nine waves from infancy through the fifth grade. They also rated adolescents' emotional reactivity in the fifth grade and behavioral problems in the fifth and sixth grades. The results showed that emotional reactivity mediated the longitudinal relations between maternal depressive symptoms and internalizing and externalizing problems in youth. The results also supported the moderation of emotional reactivity. That is, mothers' depressive symptoms were associated with high levels of internalizing and externalizing problems, particularly among youth who were high in emotional reactivity. The findings highlight the dual role of emotional reactivity to better understand the associations between mothers' depressive symptoms and offspring behavioral problems, and emphasize the need to target emotional reactivity to alleviate the adverse impacts of maternal depressive symptoms on behavioral adjustment in early adolescence.
Identification and Phylogenetic Analysis of Two Alternaria Species From Nelumbo nucifera in China
Authors: Guo Zhuan‐Jun , Liu Feng‐Yin , Aung Sein Lai Lai , Yin Jun‐Liang , Deng Jian‐Xin , Rashad Younes M. 
Published: December 2024

ABSTRACTLotus (Nelumbo nucifera Gaertn.) is one of China's 10 most renowned commercially grown ornamental flowers. However, lotus is susceptible to various fungal infections, which can affect its rich nutritional composition and ornamental value. In 2023, 12 fungal cultures were isolated from lotus leaves in Liuzhou City, Guangxi Zhuang Autonomous Region, China. Based on the phylogenetic analyses using seven gene primers (ITS, GAPDH, TEF1, Alt a 1, RPB2, EndoPG and OPA10‐2) and the phenotypic data, two species (five strains) in the section Alternaria were identified as A. melongenicola L. Zhao & J.X. Deng and A. nelumbiicola T.Y. Zhang. To the data, most of the Alternaria species found, including A. nelumbiicola, have been identified on the basis of host and morphological characteristics and no molecular data were available so far that support these earlier identifications. This study is the first worldwide report of A. melongenicola from lotus. It also provides the gene sequence information of A. nelumbiicola in GenBank, clarifies its phylogenetic position and distinguishes it from the previous classified morphospecies A. caudata which is phylogenetically considered as a synonym of A. alternata. In addition, pathogenicity test confirmed that these two Alternaria species are the causative agents of leaf spot of lotus.