bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of docosahexaenoic acid (DHA) supplementation on total antioxidant capacity (TAC), superoxide dismutase (SOD), and interleukin-6 levels in underweight pregnant women
Authors: Siahaan Salmon Charles , Santoso Budi , Ismayani Kanti , Yuwono Natalia , Aris Mohd Aznan Md 
Published: November 2024

HIGHLIGHTS

Underweight pregnant women, face an imbalance in energy and protein intake.
TAC, SOD, and IL6 with administration of DHA to pregnant women with chronic energy deficiency in the third trimester provide benefits.

ABSTRACT
Objective: Underweight pregnant women face oxidative stress and inflammation, increasing their risk of intrauterine growth restriction (IUGR) and preterm birth. This study investigates the effects of DHA supplementation on Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD), and Interleukin-6 (IL-6) in underweight pregnant women, along with the correlation between DHA and these markers.
Materials and Methods: This experimental pre-test/post-test study focused on underweight pregnant women in the Made District, Surabaya, Indonesia. Eligible participants were in their second or third trimester, had a BMI below 18.5, and were taking DHA regularly. Exclusion criteria included early pregnancy (gestational age < 14 weeks), BMI above 18.5, irregular DHA intake, and withdrawal from the study. The study ran from July to December 2023, using non-probability sampling to select participants. Blood samples were collected before and after two months of DHA supplementation.
Results: Following the intervention, TAC levels demonstrated a noteworthy increase (p < 0.05). SOD levels also exhibited a significant difference (p <0.05), and IL-6 levels showed a significant change (p < 0.05). A strong and positive correlation (r = 0.718) was observed between the increased TAC and SOD levels. DHA influenced both TAC and IL-6, with a significant relationship between TAC and IL-6 (p < 0.01). Furthermore, elevated SOD levels were associated with a decrease in IL-6 levels (p < 0.01). The correlation coefficient value of 0.718 between changes in SOD and TAC indicated a robust positive correlation.
Conclusion: The findings suggest that DHA supplementation in underweight pregnant women positively affects oxidative stress and inflammation markers, improving TAC, SOD, and IL-6 levels.
Acute fatty liver of pregnancy: An atypical case report
Authors: Subono Riska , Hikmah Nurul 
Published: November 2024

HIGHLIGHTS

Acute Fatty Liver of Pregnancy (AFLP) is an uncommon condition but life-threatening obstetric emergency, that increases the risk of fetal death due to preterm birth.
AFLP can be challenging for primary health workers (especially for general practitioners (GP) and midwives) since it mimics preeclampsia, viral hepatitis, intrahepatic cholestasis of pregnancy, and HELLPS syndrome, so more concern is needed in this case.

ABSTRACT
Objective: To present an atypical case of acute fatty liver of pregnancy.
Case Report: A 33-year-old woman was referred to the Emergency department of Dr. Soedarso Tertiary Referral Hospital, Pontianak, Indonesia, previously from the district hospital over 580 KM with diagnosis of multigravida (gravida 3 para 2) at 31 weeks gestation, suspected acute fatty liver disease (AFLP), severe oligohydramnios, and intrauterine growth restriction (IUGR). The patient had a history of nausea, vomiting, epigastric pain, polydipsia and polyuria, and seizure for less than 5 minutes with loss of consciousness. The patient originally did not know she was pregnant and using a contraceptive implant. She missed her period in the last six months ago, which was the first onset of epigastric pain. Further clinical examination resulted in pitting oedema but jaundice as a cardinal sign was not present. Laboratory data showed leukocytosis, normal haemoglobin level, normal blood glucose, hyperuricemia, increased function liver test with high transaminase and bilirubin, normal coagulation profile. Urinalysis showed proteinuria. The viral hepatitis and HIV tests were negative. Transabdominal ultrasound demonstrated a single intrauterine pregnancy with no echogenic liver features. Cardiotocography (CTG) showed category 2. This patient was diagnosed with AFLP based on Swansea Criteria (7 out of 10) and terminated pregnancy two days after diagnosis. A baby boy was born with birth weight 1.100 gr, birth length 34 cm, apgar score (AS) 9 and 10 at 1 and 5 minutes. The mother had a good prognosis, while the baby died on day 23 of life.
Conclusion: Acute Fatty Liver during Pregnancy is an uncommon but life-threatening obstetric emergency. Early screening, diagnosis, timely handling delivery, and intensive supportive care are essential to decrease morbidity and mortality for both mother and fetus. Multidisciplinary opinion needed for the best management of this case.
PENGEMBANGAN MODUL AJAR DENGAN PENDEKATAN REALISTIK PADA MATERI BANGUN DATAR UNTUK SISWA KELAS IV SD/MI
Authors: Nor Makiah  , Karim  , Elli Kusumawati  
Published: November 2024

Pembelajaran matematika materi bangun datar memerlukan pemahaman konsep yang mendalam bagi siswa sekolah dasar karena memiliki banyak simbol, rumus, dan operasi formal sementara mereka masih berada pada tahap operasional konkret. Salah satu solusi yang dapat dilaku-kan adalah dengan menyediakan modul ajar yang menarik dan berkaitan dengan kehidupan sehari-hari siswa. Modul ajar dengan pendekatan realistik diharapkan dapat menumbuhkan pembelajaran yang bermakna. Tujuan penelitian ini adalah menghasilkan modul ajar dengan pendekatan realistik pada materi bangun datar untuk siswa kelas IV SD/MI yang valid, praktis, dan efektif. Metode penelitian yang digunakan adalah metode pengembang­an (R&D) dengan model 4D. Subjek penelitian adalah siswa kelas IV SDN 3 Guntung Manggis. Instrumen pengumpulan data terdiri dari lembar validasi, angket respon guru dan siswa, serta tes. Hasil validasi modul ajar didapat­kan rata-rata persentase validator berada pada kategori valid. Hasil uji ke­praktis­an telah mencapai kriteria praktis. Hasil analisis uji keefektifan telah mencapai kategori sangat efektif. Dengan demikian, modul ajar dengan pendekatan realistik untuk siswa kelas IV SD/MI telah memenuhi kriteria valid, praktis, dan efektif.
Learning mathematics about plane figure materials requires a deep understanding of the concept for elementary school students because it has many symbols, formulas, and formal operations while their are still at the concrete operational stage. One solution that can be done is to provide teaching modules that are interesting and related to students' daily lives. Teaching modules with a realistic approach are expected to foster meaningful learning. The purpose of this research is to produce teaching modules with a realistic approach to plane figure subject matter for grade IV elementary school students that are valid, practical, and effective. The research method used is the development method (R&D) with the 4D model. The research subjects were fourth-grade students of State Elementary School 3 Guntung Manggis. Data collection instruments consisted of validation sheets, teacher and student response questionnaires, and tests. The results of the validation of the teaching module showed that the average percentage of validators was in the valid category. The practical test results have reached is practical criteria. The results of the effectiveness test analysis have reached the very effective category. Thus, the teaching module with a realistic approach for grade IV SD/MI students has met the criteria of being valid, practical, and effective.
DESKRIPSI KEMAMPUAN NUMERASI SISWA DALAM MENYELESAIKAN MASALAH AKM
Authors: Nasrullah  
Published: November 2024

Penelitian ini bertujuan mengungkap bagaimana kemampuan numerasi peserta didik melalui keterbatasan yang dimiliki siswa dalam menyelesaikan soal numerasi berbasis AKM. Jenis penelitian yang diterapkan adalah penelitian kualitatif dengan pendekatan deskriptif. Instrumen penelitian yang digunakan adalah tes modifikasi AKM dan pedoman wawancara. Teknik analisis data kualitatif diterapkan dengan dukungan prinsip kredibilitas, transferabilitas, keandalan, dan konfirmabilitas. Hasil penelitian menunjukkan bahwa keterbatasan yang dialami siswa berupa minimnya strategi komputasi untuk menyelesaikan masalah perhitungan yang dibangun dalam penyelesaian dan tidak membangun argumen secara matematis dan logis untuk mendukung penyelesaian masalah yang dikerjakan.
This study aims to reveal how the numbering ability of students through the limitations that students have in solving the issue of numbering based on AKM. The type of research applied is qualitative research with a descriptive approach. The research instruments used are AKM modification tests and interview guidelines. Qualitative data analysis techniques are applied with the support of the principles of credibility, transferability, reliability, and confirmability. The results of the research show that the limitations experienced by students are the minimum of computational strategies to solve the computational problems built in the solution and not to build arguments mathematically and logically to support the solution of the problems worked.
Research on GNSS/IMU/Visual Fusion Positioning Based on Adaptive Filtering
Authors: Liu Ao , Guo Hang , Yu Min , Xiong Jian , Liu Huiyang , Xie Pengfei 
Published: November 2024

The accuracy of satellite positioning results depends on the number of available satellites in the sky. In complex environments such as urban canyons, the effectiveness of satellite positioning is often compromised. To enhance the positioning accuracy of low-cost sensors, this paper combines the visual odometer data output by Xtion with the integrated navigation data output by the satellite receiver and MEMS IMU both in the mobile phone through adaptive Kalman filtering to improve positioning accuracy. Studies conducted in different experimental scenarios have found that in unobstructed environments, the RMSE accuracy of GNSS/IMU/visual fusion positioning improves by 50.4% compared to satellite positioning and by 24.4% compared to GNSS/IMU positioning. In obstructed environments, the RMSE accuracy of GNSS/IMU/visual fusion positioning improves by 57.8% compared to satellite positioning and by 36.8% compared to GNSS/IMU integrated positioning.
On En- Prime Compactly Packed Acts over Monoid
Authors: Kadhim Samira Naji , AL-Hussani Uhood S. , Ali Muna Jasim Mohammed 
Published: November 2024

في هذا العمل تم دراسة المقاسات الاولية من النمطEn المرصوصة المكتضة ودراسة تعيم هذا المفهوم الى مفهوم الآثار الاولية من النمط En المرصوصة المكتضة حيث تم دراسة بعض العلاقات والتشخيصات الخاصة بهذه المفاهيم حيت تم برهنت العلاقات الخاصة بمفهوم المقاسات الاولية من النمط En المرصوصة المكتضة ليكن ₩ مقاس و كل مقاس جزئي هو اولي من النمط En فان المقاس ₩ هو مقاس اولي من النمط En مرصوص مكتض اذا و فقظ اذا كل مقاس جزئي دائري و كذلك تمت برهنت اذا كان المقاس ₩ اولي من النمظ En مرصوص مكتض يمتلك على الاقل مقاس جزئي اعظم فان ₩ يحقق خاصية ACC على المقاس الجزئي الاولي من النمط En-p-radical. قد تم دراسة مفهوم الاثار الاولية من النمط En المرصوصة المكتضة والتي هي تعميم لمفهوم المقاسات الاولية من النمط En المرصوصة المكتضة حيث تم برهنت بعض الخواص وبعض التشخيصات الخاصة بمفهوم الاثار الاولية من النمط En المرصوصة المكتضة , اذا كان الاثر Д اولي من النمط En مرصوص مكتض ويمتلك على الاقل اثر جزئي اعظم فان الاثر Д يحقق خاصية ACC على الاثر من النمط En-p-radical
Synthesis and Identification of Two Dyes Derived from p-amino phenol and Study of their Effectiveness as Corrosion Inhibitors: Experimental and Theoretical Analysis.
Authors: Abdullah Aseel F. , Kathim Sura H. , Sager Athra G. , Abaies Jawad Kadhim 
Published: November 2024

تم في هذا البحث تحضير صبغتين من بار-امينو فينول من خلال تفاعل ملح الديزونيوم من بارا-امينو فينول مع مركبين اروماتي (1-نفثول وبارا-امينو فينول). تم تشخيص الصبغتين الجديدتين (a و b ) بتقنية FTIR وHNMR1 مع قياس بعض الخواص الفيزيائية. تم دراسة النشاط التثبيطي تجريبياً بواسطة القياسات الكهروكيميائية لمركبات الآزو المحضرة ضد تآكل الفولاذ الكربوني نوع C45 في وسط (HCl 0.1 M,). تم استخدام طريقة ميكانيكة الكم لحساب البنية الهندسية والخواص الفيزيائية بواسطة برنامج Gaussian 09 W ونظرية الكثافة الوظيفية (DFT) لدالة B3LYP بمستوى 6-311 +G (2d, 2p) . تم استخدام نظرية الكثافة الوظيفية في حساب معاملات كفاءة التثبيط للصبغتين في وسط مفرغ من الهواء, وأظهرت النتائج ان المركب a الافضل بالتثبيط.
Land Subsidence and Displacement Occurrence in the Urmia Plain Aquifer Using Interferometric Radar Technique and Hidden Faults
Authors: Hemmati Fariba , Khanjari Sara , Alizadeh Akram 
Published: November 2024

Abstract

The occurrence of land subsidence in a number of Iranian cities has increased, mostly due to groundwater level fluctuations, a consequence of recent structural displacements, decreased precipitation and increased rate of population. Urmia Plain Aquifer has been suffering such environmental challenges, leading to extensive land displacement. Hence, this research investigates the extent of land displacement in the Urmia Plain Aquifer from 2015 to 2023 using the Differential Interferometric Synthetic Aperture Radar (DInSAR) technique via the Sentinel Application Platform (SNAP) software and detected hidden faults. DInSAR is an efficient tool for assessing surface deformation, including land displacement. The results displayed a maximum land subsidence of 9.00 cm in the south and an uplift of 9.6 cm in the north of Urmia Plain Aquifer. Comparing the information obtained from InSAR with the groundwater level data reveals a positive strong correlation. The groundwater level in the southern parts is lower than in the north. This study indicated that land displacement, leading to the fluctuation of the groundwater level, can effectively be evaluated using InSAR, a less time-consuming and expensive technique.
Clinical differential factors in patients with hereditary transthyretin amyloidosis with Val142Ile and Ser43asn mutations
Authors: Leones Sandra Milena Castellar , Ruiz-Ospina Edicson , Diaz-Ruiz Jorge , Arrieta Cristian Correa , Ruiz-Cortés Xiomara , Luzuriaga-Carpio Diana , Zambrano-Vera Dario , Cedeño-Quincha Jeanneth , Guerrero-Cepeda Luis , Chávez Daniel Cesar , Ortiz-Corredor Fernando 
Published: November 2024

Abstract

Background: Hereditary transthyretin amyloidosis (hATTR) is a rare autosomal dominant disease with high clinical variability, influenced by both genotype and the geographic origins of carriers. There is a limited understanding of the Val142Ile and Ser43Asn recognised mutations in Ecuador and Colombia. Therefore, the objective of this study is to describe the neurological and functional characteristics of patients with hATTR associated with the Val142Ile and Ser43Asn mutations, as well as to identify possible differentiating factors between the two mutations.
Methods: This cross-sectional, multicenter study included 35 hATTR patients from rehabilitation centers in Ecuador and Colombia. Patients had confirmed Val142Ile or Ser43Asn mutations. Neurological and functional assessments included the Neurological Impairment Scale, Norfolk Quality of Life-Diabetic Neuropathy (QOL-DN), Composite Autonomic Symptom Score-31, and various motor function tests as nine-hole peg test (NHP). Quantitative Sensory Testing (QST) evaluating small fiber function, while ultrasound measured the cross-sectional area (CSA) of peripheral nerves. Statistical analysis employed nonparametric tests and random forest classifiers, using SHAP values to identify differentiating variables.
Results: Val142Ile carriers showed lower performance in the right NHP test and greater sensitivity to cold pain in hand and leg. Ultrasound revealed increased CSA of the median nerve at the elbow and arm and the ulnar nerve at the arm in Val142Ile carriers compared to Ser43Asn carriers. The final random forest model identified the NHP test, Norfolk QOL-DN score, and CSA of the median and ulnar nerves as key discriminating variables.
Conclusion: This study identified significant neurophysiological and ultrasound markers differentiating Val142Ile and Ser43Asn mutations in hATTR-PN patients. Increased nerve CSA and specific motor and sensory impairments highlight the need for comprehensive evaluations to guide diagnosis and treatment.
Resistance Mutations Impair Benzimidazole Efficacy Against Ascaridia galli by Altering β-Tubulin Interactions
Authors: Tenorio Jan Clyden 
Published: November 2024

Abstract

Background The emergence of benzimidazole resistance among helminths of veterinary and public health importance has been of grave concern. Benzimidazole resistance is caused by mutations (i.e., F167Y, E198A, and F200Y) that occur in the β-tubulin genes of helminths thereby affecting the structure of the expressed protein. This research aims to determine the effects of these canonical resistance-associated mutations on the in silico binding of A. galli β-tubulin and benzimidazole drug ligands.Methods The β-tubulin amino acid sequence of A. galli was retrieved and edited to contain the resistance-associated mutations. These were used to model the tertiary structure of the protein. The in silico docking studies used the modeled proteins with benzimidazole drug ligands (i.e., Fenbendazole, Mebendazole, Oxfendazole, and Albendazole). The binding affinities (kcal/mol) and docking positions were examined.Results The results show that resistance-associated mutations caused alterations in the binding interactions between the A. galli β-tubulin and benzimidazole drug ligand. The E198A mutation caused slight reductions in binding affinities and changes in the binding positions indicating its potential role in conferring benzimidazole resistance. Molecular dynamics simulations revealed that wild-type and mutated A. galli β-tubulins share comparable binding behavior with Fenbendazole. The binding free energies show that the E198A mutation caused decreased binding efficacy potentially causing resistance.Conclusion The E198A mutation causes weakening of the β-tubulin-benzimidazole interactions indicating its crucial role in conferring resistance in A. galli. The emergence of these benzimidazole resistance-associated mutations should be assessed in field isolates as they may negatively affect the efficacy of pharmacological interventions.
Students Satisfaction with Nursing Program Studying at Tribhuvan University, Institute of Medicine, Nepal
Authors: Chaudhary Angira Kumari , Dahal Tulasha , Niraula Achala , Mandal Punam Kumari 
Published: November 2024

Abstract

Background: Satisfaction is the psychological state, which results from confirmation or disconfirmation of expectations with reality. Student satisfaction involves the student's unique perception of the value of his/her educational experience during the degree program. Satisfaction is the key element and criterion to evaluate and represent the level of customer pleasure, program quality, student’s achievement and program success.
Objectives: The objectives of the study were to assess the satisfaction of nursing students with the nursing program.
Materials and Methods: Cross-sectional study was conducted in the five constituent nursing campuses TU from the period of 8th Nov 2022 to 8th March 2023 to identify their satisfaction with the nursing program. Adopted and modified tools were employed to gather students’ satisfaction with a nursing program. Data was collected from 147 students of nursing studying in the third year through the census method by using a self-administered semi-structured questionnaire. Data analysis was done using descriptive and inferential statistics.
Results: The result of the study showed that near three fourth (74.1%) of the students’ overall satisfaction with the Bachelor of Science with the nursing program was fair level (meanscore=219.86). The highest mean of satisfaction with the program subdomain was curriculum (mean score=44.73) where more than half (63.9%) of student’s had a good level of satisfaction and the lowest mean satisfaction was with theoretical education by faculty (mean score=24.98) where near three fourth (72.1%) student’s satisfaction had poor level. In other of subdomains of the study, like professional social interaction, clinical practice by clinical Guide, and educational environment where nearly two thirds (65.3%, 64.6%, 58.5%, and 69.4%) of students had fair level respectively, and with resource and support was poor level satisfaction. More than one forth (34.7%) of students’ satisfaction with the evaluation system of the institute was fair level.
Conclusion: The study indicated that students have a fair level of satisfaction with the nursing program so it is necessary for continuous innovation and quality services in nursing campus for student’s optimum satisfaction.
Effects of Seasonal Climates and MIPS Mutations on Soybean Germination through Multi-Omics Analysis
Authors: Yu Huakun , Zhu Longming , Chen Yuhao , Deng Ping , Liu Bei , Chen Xiaochao , Yuan Fengjie 
Published: November 2024

Abstract

This study delves into the combined effects of seasonal climate variations and MIPS gene mutations on the germination rates of soybean cultivars TW-1 and TW75. Through comprehensive metabolomic and transcriptomic analyses, we identified key KEGG pathways significantly affected by these factors, including starch and sucrose metabolism, lipid metabolism, and amino acid biosynthesis. These pathways were notably disrupted during the spring, leading to an imbalance in metabolic reserves critical for seedling development. Additionally, MIPS gene mutations further altered these pathways, exacerbating the metabolic disturbances. Our results underscore the intricate network of environmental and genetic interactions influencing soybean seed vigor and underscore the importance of understanding these pathways to enhance agricultural resilience and seed quality in fluctuating climates.
Environmental discrimination through urban planning: the case of French Traveler site
Authors: Tardieu Léa , Mondolfo Nicolas , Leblois Antoine , Delacote Philippe 
Published: November 2024

Abstract

Ethnic minorities often face environmental inequalities, as they are generally more likely to be exposed to hazardous and polluting facilities. Despite this, the role of urban planning decisions in shaping these inequalities has been insufficiently explored. The siting of Traveler sites provides a clear example of how political decisions in urban contexts can exacerbate environmental disparities. To address this issue, we constructed an original database that links the siting of French Traveler sites with socio-economic and environmental data. Then, we conducted a statistical analysis to identify the factors that determine the placement of sites, both across and within municipalities. Our study demonstrates that Traveler sites are more likely to be implemented in municipalities with greater disamenities and that, within these municipalities, sites are located closer to these disamenities than other residential areas. Based on our findings, we discuss two potential mechanisms underlying the planning decisions regarding sites: the opportunity cost and discriminatory preferences.