bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Historical Review of Persian Medicine Studies into Saliva Manifestations for Potential Applications for Diagnosis and Management of Metabolic Syndrome
Authors: Hakimi Fatemeh , Choopani Rasool , Asghari Majid , Namdar Hasan , Parsa Elham , Jafari Parisa , Movahhed Mina 
Published: June 2019

Background and Objective:
Regarding the development of diagnostic tests based on saliva
and the prevalence of metabolic syndrome (MetS), the aim of this study is to review Persian Medicine
manuscripts in the field of saliva manifestations, its relation to metabolic syndrome, and treatment
recommendations.

Method:
This study is a mini-review. We investigated the canon of medicine and some important
Persian medical or pharmaceutical manuscripts from the 9th to the 19th centuries. PubMed and Google
Scholar databases were explored for finding relevant information about the relationship between saliva
and metabolic syndrome and its treatment.

Result:
Studies have suggested that maldigestion is one of the important causes of MetS. Sialorrhea
may be an early symptom of maldigestion. Attention to sialorrhea and its treatment may be useful in
the prevention and treatment of metabolic syndrome based on PM sources. In PM, sialorrhea is treated
with 3 major approaches: lifestyle modification along with simple or compound medicines.

Conclusion:
Saliva manifestations could be considered as early symptoms of metabolic syndrome. As
mentioned in WHO strategies, traditional medicine can be used along with modern medicine due to its
effectiveness in the management of various ailments.
Power Management for Plug-in Hybrid Electric Vehicle with Automated Mechanical Transmission using Multiple Dimensional Scaling Method
Authors: Wang Zhenyou , Sun Qun , Guo Hongqiang , Zhao Ying 
Published: June 2019

Background:
The study of kerosene fuel for gasoline engines is of great significance to
the supply, management, storage and transportation of military fuel, as well as its safety. Small aviation
two-stroke kerosene engine fuel injection controller is the key technology of kerosene engines. It
is very important to improve the performance of kerosene engine by controlling the air-fuel ratio
accurately.

Objective:
The initial injection pulse spectrum was firstly obtained by numerical calculation in the
absence of kerosene injection pulse spectrum, and then the injection controller was designed based
on the initial injection pulse spectrum.

Methodology:
Firstly, a numerical model of the whole engine was established by using BOOST
software. The air mass flow data of the inlet was obtained through numerical calculation. The
amount of initial engine fuel injection was calculated according to the requirements of air-fuel ratios
in each working condition, from which an initial injection pulse spectrum was obtained. Then, based
on Free scale 16-bit embedded micro-controller MC9S12DP512, a kerosene engine fuel injection
controller was developed, together with the circuit was also designed. According to the initial fuel
injection pulse spectrum, a two-dimensional interpolation algorithm was developed by using assembly
language and C language mixed programming, and the anti-electromagnetic interference ability
of the controller was further enhanced. Finally, the accuracy of the initial injection pulse spectrum
and the performance and reliability of the injection controller of the kerosene engine were verified by
the kerosene engine bench test.

Conclusion:
The experimental results show that the numerical model was accurate, and the development
time of the injection controller was shortened by using the numerical model to calculate the
initial injection pulse spectra. The developed controller was stable and reliable, which can meet the
control requirement.
Improvement of Anti-Tumor DNA Vaccination by Co-Immunization at a Distant Site with a Plasmid Encoding the Hemagglutinin-Neuraminidase Protein of Newcastle Disease Virus
Authors: Ni Jing , Schirrmacher Volker , Fournier Philippe 
Published: June 2019

DNA vaccine encoding tumor associated antigens (TAAs) is an attractive strategy for tumor vaccine development. But its efficacy to induce efficient anti-tumor immunity needs to be improved. In this study, we combined immunization with such a plasmid at the ear pinna site (i.e.) with co-immunization with another plasmid (pHN) encoding the Hemaglutinin-Neuraminidase (HN) protein of the NDV virus at a subcutaneous site. We first tested a prophylactic immunization protocol followed by subcutaneous challenge with the ESb-lacZ lymphoma expressing the 􀀂-galactosidase protein as a surrogate tumor antigen. While i.e. vaccination with the placZ plasmid reduced tumor growth, the additional s.c. immunization with the pHN plasmid further improved this effect. We next tested a therapeutic tumor model based on the mammary carcinoma DA3-hEpCAM expressing the human EpCAM molecule. Efficient reduction of tumor growth was achieved by immunization of tumor-bearing mice with DNA plasmids encoding the human EpCAM gene only when it
was combined with s.c. application of the pHN plasmid. A significantly better cross-protection against a second challenge with the parental DA3 tumor cells was only observed when mice were initially co-immunized with both plasmids.
These results demonstrate that co-immunization of a plasmid encoding the HN protein of NDV and a DNA vaccine encoding a tumor antigen significantly reduced tumor growth in mouse tumor models employing both prophylactic and therapeutic vaccination strategies. These observations point towards the HN protein of NDV as a powerful molecular adjuvant for DNA vaccines.
An Overview of the Design, Development and Applications of Biodegradable Stents
Authors: Nakka Keerthana , Nagarajan Sri D. , Sundaravadivel Balamayilsamy , Shankaravel Subramanian , Vimalson Christopher 
Published: June 2019

Background & Objectives:
Stents have been effectively used in the treatment of vascular
diseases and further explorations are going on in treating various strictures including tracheal, intestinal,
nasal, urethra and esophageal. Stents serve as a support to walls of the lumen to prevent restenosis.
Metal stents prevent in-stent restenosis but the corrosion of the metallic framework causes further complications.
To overcome the shortcomings of metallic stents, metallic Drug-Eluting Stents (DES) have
been designed where the drugs are chosen as an anti-restenosis agent in such a way that it prevents
thrombosis, neointimal proliferation and possess immunosuppressive properties. Biodegradable stents
are becoming ideal, provided they effectively spot the target stricture and have long-term stability to
support the walls of the body conduit which in turn aids in eliminating the need for a second surgery.
Polymeric materials can be used to enhance the mechanical strength and prolong the degradation time
of biodegradable DES, thereby making it an ideal choice for stenting.

Discussion:
This review focus on the progress made in the design, manufacture, characterization studies
and applications of stents over the past decade.

Conclusion:
We concluded that the use of stents is now an emerging technique for the treatment of GI
strictures caused due to colorectal cancer, esophageal cancer, cholangiocarcinoma, Crohn’s disease etc.
Though BDS have several advantages, advanced techniques are needed for fabrication and suitable
modification in the design of the scaffold to enhance its clinical efficacy and to thereby develop an ideal
endoprosthetic device.
Prediction of Breast Cancer Using Machine Learning
Authors: Jain Somil , Kumar Puneet 
Published: June 2019

Background:
Breast cancer is one of the diseases which cause number of deaths ever
year across the globe, early detection and diagnosis of such type of disease is a challenging task in
order to reduce the number of deaths. Now a days various techniques of machine learning and data
mining are used for medical diagnosis which has proven there metal by which prediction can be
done for the chronic diseases like cancer which can save the life’s of the patients suffering from
such type of disease. The major concern of this study is to find the prediction accuracy of the classification
algorithms like Support Vector Machine, J48, Naïve Bayes and Random Forest and to
suggest the best algorithm.

Objective:
The objective of this study is to assess the prediction accuracy of the classification algorithms
in terms of efficiency and effectiveness.

Methods:
This paper provides a detailed analysis of the classification algorithms like Support Vector
Machine, J48, Naïve Bayes and Random Forest in terms of their prediction accuracy by applying
10 fold cross validation technique on the Wisconsin Diagnostic Breast Cancer dataset using
WEKA open source tool.

Results:
The result of this study states that Support Vector Machine has achieved the highest prediction
accuracy of 97.89 % with low error rate of 0.14%.

Conclusion:
This paper provides a clear view over the performance of the classification algorithms
in terms of their predicting ability which provides a helping hand to the medical practitioners
to diagnose the chronic disease like breast cancer effectively.
Email Fraud Attack Detection Using Hybrid Machine Learning Approach
Authors: Yaseen Yousef A. , Qasaimeh Malik , Al-Qassas Raad S. , Al-Fayoumi Mustafa 
Published: June 2019

Background:
E-mail is an efficient way to communicate. It is one of the most commonly used communication methods, and it can be used for achieving legitimate and illegitimate activities. Many features that can be effective in detecting email fraud attacks, are still under investigation.

Method:
This paper proposes an improved classification accuracy for fraudulent emails that is implemented through feature extraction and hybrid Machine Learning (ML) classifier that combines Adaboost and Majority Voting. Eleven ML classifiers are evaluated experimentally within the hybrid classifier, and the performance of the email fraud filtering is evaluated by using WEKA and R tool on a data set of 9298 email messages.

Results:
The performance evaluation shows that the hybrid model of Voting using Adaboost outperforms all other classifiers, with the lowest Error Rate of 0.6991%, highest f1-measure of 99.30%, and highest Area Under the Curve (AUC) of 99.9%.

Conclusion:
The utilized proposed email features with the combination of Adaboost and Voting algorithms prove the efficiency of fraud email detection.
РЕЗУЛЬТАТИ КОМПЛЕКСНОГО ІМУНОТРОПНОГО ЛІКУВАННЯ ХВОРИХ НА ГЕНЕРАЛІЗОВАНИЙ ПАРОДОНТИТ ІЗ СУПУТНЬОЮ ІШЕМІЧНОЮ ХВОРОБОЮ СЕРЦЯ, ЗАСТОСОВУЮЧИ ПРЕПАРАТИ РОСЛИННОГО ПОХОДЖЕННЯ
Authors: Стасюк Н. О. 
Published: June 2019

Резюме. Проведений аналіз літературних джерел вказує на те, що проблема взаємозв’язку «пародонтит-ІХС» розглядається неповно та часто односторонньо.
Обстеження хворих на стабільну ІХС із використанням коронароангіографії показало тісний зв'язок із високими середніми значеннями індексів ураження пародонта (ясенна рецесія, кровоточивість при зондуванні, величина кишень), що дозволило авторам зробити висновок про тісний зв'язок обох недуг.
Досить часто є проблематичним досягнення довготривалої, якісної ремісії захворювання: повного усунення клінічних ознак запалення в пародонті та тривалої стабілізації кісткової резорбції. Тому традиційний підхід до загального лікування ГП вимагає оптимізації. З огляду на вищесказане, метою нашої роботи було підвищити ефективність лікування ГП у хворих на ІХС шляхом застосування комплексної імунотропної терапії.
Для досягнення поставленої мети були сформульовані цілі: вивчити вплив запропонованої імунотропної терапії ГП у хворих з ІХС на показники пародонтального статусу. Із метою виконання цілей було проведено методи обстеження: визначення індексів запалення в породонті РМА, кровоточивості РВІ, гігієни ІГ, глибини пародонтальних кишень (ПК), пародонтальний за Рамфьордом PDI.
Запропонована схема лікування включала традиційний підхід та додатково прийом всередину препарату «Імуно-тон», а також інстиляції в пародонтальні кишені екстемпорального гелю на основі фітоконцентрату «Джерело» та «Ентеросгелю».
Отримані результати вказують на те, що застосування запропонованої методики лікування виявляє достовірно вірогідно більш значущий вплив на перебіг ГП та покращення стану тканин пародонта, у порівнянні із традиційним підходом.
ЗНАЧЕННЯ ХРОНОРИТМІВ У РЕГУЛЯЦІЇ ФІЗІОЛОГІЧНИХ ФУНКЦІЙ ОРГАНІЗМУ ЛЮДИНИ: ОГЛЯД ЛІТЕРАТУРИ
Authors: Семененко С. Б. , Тимофійчук І. Р. , Борейко Л. Д. , Юрків О. І. , Слободян К. В. 
Published: June 2019

Резюме. Згідно з даними літературних джерел, біологічні ритми людини – це певні частоти, від швидкості і сповільнення яких залежить функціонування органів і систем організму людини, її психологічний стан. У здорових людей ритми фізіологічних процесів синхронізовані як між собою, так і з ритмами навколишнього середовища, а синхронізація біоритмів, збереження їх фазових спiввідношень забезпечують оптимальнi умови функцiонування органiзму i є ознакою здоров’я.
Роль епіфізу і епіфізарного гормону мелатоніну в добовій і сезонній ритміці, режимі сну-активності на сьогоднішній день є беззаперечною. У тварин і людини секреція мелатоніну епіфізом співпадає зі звичайними годинами сну. Існує гіпотеза, що мелатонін відіграє важливу роль у відкритті так званих воріт сну та в гальмуванні режимів активності. Секреція мелатоніну підпорядкована циркадіанному ритму. Концентрація гормону в крові максимальна в темний час доби, мінімальна – у світлий. Синтез і активність гормону збільшується після заходу сонця, а пік концентрації відзначається близько 3-ї години ночі.
Мета цього дослідження полягає у вивченні хроноритмів регуляції фізіологічних функцій організму людини та аналізі впливу десинхронозу.
Матеріали і методи. Аналіз вітчизняної та зарубіжної літератури, де висвітлюються фізіологічне значення хроноритмів та проблеми десинхронозу.
Обговорення результатів. Аналіз змін хроноритмів та їх неузгодженість допомагає визначати нові підходи для діагностики, профілактики та вдосконалення часових схем терапевтичних заходів при захворюваннях різних форм перебігу.
Висновки. Отримані дані вказують на вплив процесів десинхронозу на органи і системи організму та пояснюють роль механізмів адаптації організму до навколишнього середовища.
EXPERIMENTAL DETERMINATION OF CONVECTIVE HEAT TRANSFER COEFFICIENTS IN THERMAL BUOYACY VENTILATION SYSTEM
Authors: Abramkina D. V. , Abramyan A. A. , Shevchenko-Enns E. R. 
Published: June 2019

Objectives. The main goal of the article is to present the developed method for the experimental determination of convective heat transfer coefficients, suitable for studying the internal convection of models of complex configuration. Method. The study of free convection under the conditions of an internal problem was carried out by determining the conditional thickness of the boundary layer by a graphic method. The first was the selection of the calculated sections and planes for the experimental installation. The selection is carried out in such a way that the calculated planes are perpendicular to the heated walls of the channel in question. Installation of an experimental model is possible only in a room with low internal air mobility, as well as a stable temperature. In this room there should not be heating and heating devices that can create strong convective currents near the channel of the experimental installation. Result. The article presents the results of an experimental study to determine the temperature distribution of the air flow and average convective heat transfer coefficients over the height of the ventilation channel. A decrease in convective heat transfer coefficients at an altitude of 0.5 to 1 meter occurs less noticeably than at an altitude of 1 to 2 meters, which is associated with the restoration of flow after a vent removal. At the stabilization section, there is first a gradual decrease, and then an increase in axial velocity, which is caused by the merging of multidirectional air flows in this area. Conclusion. It was revealed that in the case of modeling free convection under the conditions of an internal problem in the presence of heat-removing boundaries within the limits of the calculated temperature difference, taking into account the flow turbulization has practically no effect on the final results.
INVESTIGATION OF THE CARRYING CAPACITY OF REINFORCED CONCRETE SLABS WITH CRACKS AFTER THEIR REINFORCEMENT WITH COMPOSITE FABRICS BY THE FINITE ELEMENT METHOD USING THE PRINS COMPUTER COMPLEX
Authors: Agapov V. P. , Aydemirov K. R. 
Published: June 2019

Objectives. The finite element method for cracked reinforced concrete slabs analysis after they were reinforced with composite fabrics in order to determine the residual safety factor is considered.Method. The method is based on the use of algorithms for calculating of structures with the account of the geometrical and physical nonlinearities, implemented in the PRINS program. These algorithms assume the use of the same calculation scheme in the process of the problem solving. However, the specifics of the assigned problem is that the design sсheme of the structure before the appearance of defects in it and after its amplification with the help of composite materials should change.Result. Taking into account this circumstance, the algorithms of nonlinear calculation of structures under the PRINS program were supplemented with an option that allows changing the parameters of the design scheme in the process of through calculation. To study the bearing capacity of reinforced concrete slabs, multilayer finite elements are used, for each of which a specific package of materials is specified. Modernization of the design scheme in this case comes down to replacing one package of materials with another. An example of calculation of a slab with a crack reinforced with composite fabric is given.Conclusion.It is shown that the use of a tunable design scheme can significantly improve the accuracy of calculations. In this case, the final result depends on what stage of the formation of defects in the slab its strengthening is realized. The special multilayered finite elements of a quadrangular shape are used in calculations. The elements consist of four simple triangles, for which most of the matrix characteristics are calculated in a closed form. This is especially important when carrying out nonlinear calculations that require repeated computations of these characteristics.
STRESSED STATE OF A SYSTEM OF THREE PARALLEL TUNNELS WITHOUT DRAWING FROM OWN WEIGHT OF AN ANOTROPHONE ROCK MASSIF
Authors: Bautdinov D. T. , Djamaludinov M. M. , Zhukova K. S. 
Published: June 2019

Objectives. The aim of the study is to carry out a parametric analysis of the stress state of an anisotropic rock massif on the contours of the workings of a system of three parallel circular tunnels without lining due to the mass of the massif, for various ratios of the elastic characteristics of the rock massif in orthogonal directions, and at different distances del transverse isotropic medium. Method. The calculation of a system of three parallel tunnels without a large extension lining, laid in a strong transversely isotropic rock massif, is reduced to the problem of plane deformation of the theory of elasticity for a transversely isotropic medium containing parallel workings. A model of a transversely isotropic medium (a special case of an anisotropic medium) is used, in which the rock massif in one plane has the characteristics of an isotropic medium (the isotropy plane), and in the perpendicular direction, characteristics different from the isotropic medium. The stress state was investigated by the finite element method using the ANSYS software package. The sizes and type of the finite element suitable for calculation on the basis of the solution in the program complex of the verification task were previously determined. The Kirsch problem was accepted as the verification problem. Result. The relative tangential stresses on the contours of three parallel tunnels were determined depending on the degree of anisotropy of the rock mass and depending on the distance between parallel tunnels. The influence of the distance between the tunnels on the stress state on the contours of three parallel tunnels was evaluated, depending on the degree of anisotropy.Conclusion. The results of a parametric analysis of the system of three parallel free-flow tunnels without lining, depending on the degree of anisotropy of the rock mass and the distance between the tunnels, show that the stress state is significantly affected by the degree of anisotropy of the elastic properties of the soil massif and the distance between the tunnels. When designing underground structures, it is necessary to take into account the anisotropy of the elastic properties of the soil mass. It is also necessary to determine in more detail the physical and mechanical properties of rocky soils and pay special attention to elastic characteristics. As studies have shown, taking into account transverse-isotropy and the distance between the tunnels leads to both an increase and a decrease in tangential stresses on the contours of parallel tunnels. At some ratios of elastic characteristics in orthogonal directions, regardless of the distance between the tunnels, there are no tensile stresses on the contours of the tunnels, which favorably affects the operation of the hydraulic tunnel.
THERMOELECTRIC DEVICE FOR TREATMENT PANARIATION
Authors: Dvorjanchikov V. I. , Magomedov D. A. , Magomedova K. A. , Mispahov I. Sh. 
Published: June 2019

Objectives The aim of the study is to develop a thermoelectric device for the treatment of felon, its mathematical modeling, experimental tests of the laboratory model of the device, the study of thermal processes occurring in it. Method. A design of a thermoelectric device for the treatment of felon, providing the possibility of both uniform and contrasting therapeutic heat effects on the fingers is proposed. Result. A mathematical model of the device has been developed, implemented on the basis of solving a non-stationary two-dimensional heat conduction problem for a system of complex configuration with boundary conditions of the second and third kind. Experimental studies of the device were carried out on a specially designed test bench for checking the adequacy of the mathematical model. A two-dimensional non-stationary heat conduction problem was solved for a complex system with a rectangular geometry of fragments and heat sources. The temperature change of various points of the “device-object” system of exposure in space and in time at various values of the cooling and heating capacity of a thermoelectric battery (TEB) was studied. Comparison of calculated and experimental data. Conclusion. The results of research have shown the effectiveness of the use of the developed device for the implementation of thermal procedures in the treatment of felon in terms of efficiency, versatility, impact reliability, comfort and accuracy of maintaining temperature conditions. It is shown that it is possible to increase the efficiency of the device using a combination of thermopile operation modes (maximum cooling capacity and maximum coefficient of performance), as well as improving the intensity of heat removal from its reference junctions.