bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stimulus Sensitive Smart Nanoplatforms: An Emerging Paradigm for the Treatment of Skin Diseases
Authors: Divya  , Kaur Gurpreet 
Published: January 2019

Background:
Over the past century, the prevalence of skin diseases has substantially increased. These diseases present a significant physical, emotional and socio-economic burden to the society. Such conditions are also associated with a multitude of psychological traumas to the suffering patients. The effective treatment strategy implicates targeting of drugs to the skin. The field of drug targeting has been revolutionized with the advent of nanotechnology. The emergence of stimulus-responsive nanoplatforms has provided remarkable control over fundamental polymer properties for external triggers. This enhanced control has empowered pioneering approaches in the treatment of chronic inflammatory skin diseases.

Objective:
Our aim was to investigate the studies on smart nanoplatforms that exploit the altered skin physiology under diseased conditions and provide site-specific controlled drug delivery.

Method:
All literature search regarding the advances in stimulus sensitive smart nanoplatforms for skin diseases was done using Google Scholar and Pubmed.

Conclusion:
Various stimuli explored lately for such nano platforms are pH, temperature, light and magnet. Although, the scientists have actively taken up this research topic but there are still certain lacunaes associated which have been discussed in this review. Further, an interdisciplinary collaboration between the healthcare providers and pharmacists is a pivotal requirement for such systems to be available for patients.
El desempeño docente en el sistema tutoral del plan único de especialización en enfermería
Authors: Pérez Rodríguez Ma. Teresa 
Published: January 2019

La evaluación de la práctica docente en el Sistema de enseñanza Tutoral del Plan Único de Especialización en Enfermería (PUEE), es una tarea sumamente compleja, que puede realizarse con diferentes enfoques por las diversas dimensiones que deben analizarse. Con esta investigación de corte descriptivo, observacional y transversal, se abordó el desarrollo de las actividades de los profesores que forman parte del Sistema de enseñanza Tutoral del PUEE, desde las experiencias y opiniones que manifestaron los 39 alumnos de la primera generación de egresados en 1998.
Las opiniones de los alumnos de cinco de las especializaciones sobre las que se indagó (Enfermería del Adulto en Estado crítico; del Anciano; Cardiovascular e Infantil) son homogéneas entre sí, con una tendencia a calificar de parcial el cumplimiento de los objetivos de las diferentes modalidades de enseñanza que incluyen esta propuesta curricular. La excepción la constituye la especialidad en Salud Pública, cuyos estudiantes manifestaron mayor grado de satisfacción con el desarrollo del curso.
Se destaca que la metodología y las técnicas de enseñanza de la mayoría de los tutores, son tradicionales y en opinión de los alumnos promueven el aprendizaje parcialmente. Esto nos hace pensar que será necesario contar con diversas estrategias de formación docente permanentes, ya que se trata de modificar esquemas muy arraigados respecto a las formas de enseñar Enfermería y la conceptualización del aprendizaje, tanto en el aula como en el entorno clínico. Esta investigación se concluyó en el año 2000.
Percepción de empleadores sobre el Licenciado en Enfermería de la Facultad de Estudios Superiores Zaragoza
Authors: Crespo Knopfler Silvia , González Velázquez María Susana , Cuamatzi Peña María Teresa , Domínguez Villanueva Leticia , González Nila Lucía Ivonne 
Published: January 2019

Introducción: Actualmente el mundo se enfrenta a una situación de mayor competencia comercial y económica entre los países, lo cual crea una necesidad de responder a las demandas que esta situación exige. Esta investigación nos permitió identificar la opinión de los empleadores sobre la formación y el desempeño profesional del egresado de la licenciatura en Enfermería. Objetivo:Determinar la percepción de los empleadores sobre el perfil del Licenciado en Enfermería e identificar en que aspectos es necesario reforzar su formación y facilitar su inserción laboral. Metodología: Se trata de un estudio descriptivo, transversal donde se utilizó un cuestionario dirigido a los empleadores del sector salud y el cual se calificó en base a la escala de Likert. Para la captura y elaboración de la base de datos se utilizó el programa estadístico SPSS versión 11.5. Resultados: El 43.5% de los empleadores califican el desempeño laboral del licenciado como muy bueno; 93% de los empleadores consideran que es muy importante reforzar las habilidades en la toma de decisiones, 86% en técnicas y trabajo en equipo, 81.5% en conocimientos generales y proceso enfermero, 79% en conocimientos especializados, 76.8% en investigación y 58.2% en conocimientos básicos en ciencias biomédicas, sociales y de la conducta. Conclusiones: Los empleadores opinaron que el desempeño laboral del licenciado es muy bueno y están satisfechos con los conocimientos especializados, sin embargo, hacen énfasis en profundizar más en los mismos, así como reforzar la habilidad en la toma de decisiones, en técnicas, trabajo en equipo, conocimientos generales, aplicación del proceso enfermero y modelos y teorías de Enfermería.
Los componentes económicos de governance (gobernancia)
Authors: Vicher Diana 
Published: January 2019

<p align="right"> </p><p>Una de las palabras que mayor influencia ha tenido y continúa en boga es governance, que hoy día se acompaña con cualquier calificativo como empresarial, económica, global, mundial, metropolitana, de las tecnologías de la información, e incluso como sinónimo de gobernabilidad. La diversidad de significados usos ha generado un laberinto. En este trabajo se ofrece una revisión a los planteamientos económicos neoinstitucionales y de la Organización para la Cooperación y el Desarrollo Económico (OCDE), desde los que se generó una de las tantas versiones del uso actual de gobernancia. De aquí que se ubica su origen, planteamientos centrales y vinculación con otras ideas de gobernancia que han utilizado para reformar al Estado y la administración pública.</p><p> </p>
PROGRAM PENGABDIAN KEPADA MASYARAKAT PELATIHAN APLIKASI AKAD JASA KEUANGAN KOPERASI SYARIAH, BAGI KELOMPOK UMKM DI CEMPAKA PUTIH
Authors: Setianingrum Any 
Published: January 2019

Pelatihan akad syariah diberikan kepada para PKL (Pedagang Kaki Lima), yang berlokasi di Cempaka Putih Timur berdekatan dengan Universitas YARSI, bertujuan sebagai persiapan sebelum membentuk koperasi secara resmi. Diharapkan saat koperasi telah resmi terbentuk, anggota dan pengurus telah menguasai betul bagaimana operasional koperasi berbasis syariah. Akad-akad syariah, yakni mudharabah, ijarah dan syirkah dapat membantu PKL dalam bekerja sama untuk mencapai tujuan produksi dan pemasaran. Berbagai kerja sama dengan akad syariah yang dapat dilakukan para PKL antara lain pembelian sembako, perawatan tenda penjualan dan pengadaan gudang, supaya dapat menekan harga produksi dan jual. Akad syariah juga dapat memenuhi kebutuhan anggota keluarga PKL seperti berobat, biaya sekolah anak dan lain-lain biaya emergensi keluarga supaya tidak mengganggu perputaran uang usaha. Kata Kunci: koperasi, akad syariah, PKL, uang usaha.
Foreign Institutional Investors and Corporate Voluntary Disclosure Around the World
Authors: Tsang Albert , Xie Fei , Xin Xiangang 
Published: January 2019

ABSTRACT
We examine the impact of foreign institutional investors on firms' voluntary disclosure practices measured by management forecasts. In a sample of 32 non-U.S. countries, we find that, on average, foreign institutional investments lead to improved voluntary disclosure, and their impact is larger than that of domestic institutional investors. These results are more pronounced when foreign institutional investors (1) are unfamiliar with the firm's home country, (2) have longer investment horizons, and (3) are from countries with stronger investor protection and disclosure requirements than the firm's home country. However, we also find some evidence of voluntary disclosure deterioration in firms with foreign institutional investors from countries with inferior disclosure requirements and securities regulations and with concentrated foreign institutional ownership. Overall, our results suggest that the relation between foreign institutional investors and voluntary disclosure is much richer and more complex than what has been documented for domestic institutional investors in the literature.
El ajuste en videojuegos: el doblaje de Assassin’s Creed Syndicate
Authors: Mejías-Climent Laura 
Published: January 2019

El objetivo de este artículo es describir la localización de videojuegos desde la novedosa perspectiva del doblaje: concretamente, se centra en analizar el tipo de sincronización que presenta un videojuego de aventuras, originalmente en inglés y localizado al español peninsular.En primer lugar, se ofrece una revisión teórica de los tipos de ajuste descritos hasta ahora para cine y televisión, cuyo doblaje será el modelo sobre el que se analizará el nuevo producto audiovisual interactivo que representan los videojuegos.
The Books or the Computers: An Attitude Comparison Study from Rural Areas
Authors: YAKIN İlker , TINMAZ Hasan 
Published: January 2019

Information and Communication Technologies have altered human lives from the deep inside. On the other hand, not everyone is fortunate enough to access and utilize technologies like others. In that sense, humanity has witnessed not only technological advancements but also digital divides. The literature discusses that digital divide varies in accordance with the location of living, gender, socio-economic or educational background, and so forth. This study focuses on digital divide issue in rural area context by comparing attitudes of high school students (n=412) toward books and computers. In the light of technologies, people have initiated a discussion on whether students will be better learners with computers where the digital divide will make rural area students at disadvantaged. The survey included (i) demographics, (ii) the same attitude sentences toward computers (21 items) and books (21 items), separately (42 items in total), (iii) 17 items on preferences computers over books or vice versa. The convenience sampling collected data was analyzed and resulted several such as a tendency toward books for learning activities whereas a tendency toward computers for leisure. Gender (male vs. female), type of school enrolled (regular versus vocational), having a library or a personal computer at home, and location of living (county center versus village) were considered as other variables toward attitudes in a rural area context.
Development of E-government in Russia: Problems and Prospects
Authors: Litvinova T. N. 
Published: January 2019

Introduction. The article gives an assessment of the e-government development in Russia from 2008 to 2018. E-government contributes to the development of the state’s information infrastructure, improves the effciency of public service delivery to the society and attracts the public to participate in the process of developing and adopting government decisions. The article presents a comparative analysis of the development of the electronic government of Russia with other countries. The key issues of improving e-government in Russia are identifed on the basis of the UN e-government development index. This indicator allows assessing whether the state is ready to provide electronic public services to citizens and what are its opportunities for using information and communication technologies in providing these services.Materials and methods. Electronic government has become the subject of a wide range of disciplines, including political communication and sociology. Currently, scientists are paying increasing attention to the intersection of technological factors, equipment and culture in the adoption and use of information and communication technologies (ICT), e-government research has begun to demonstrate some diversifcation. Russian scientists mostly focus on the statistic data of implementation of egovernment and consequences for governance and society. This investigation is based on following methods: 1) content-analysis of offcial documents of the Russian Federation concerning e-government; 2) declarations and interviews of offcial authorities; 3) monitoring of mass media; 3) international and national statistics data analysis.Study results. Russia has relatively good indicators of e-government development in the world (according to UN e-Government Development Index), and the introduction of e-government is quite fast. But, in comparison with the leading countries, Russia still lags far behind in many respects because of: huge territory; low level of distribution of electronic services; low activity of mobile communication; weak dynamics of the increase in the number of Internet users; lack of the necessary law regulatory framework; low computer literacy of many government offcials.
AVALIAÇÃO DOS IMPACTOS SOCIAIS DA SECA NO MARANHÃO NO PERÍODO DE 2010 A 2016
Authors: Costa Vera Raquel Mesquita , Silva Gilvanele Silva Oliveira da , Ferreira Aretha Rayara Teixeira , Lima Janelson Martins de , Nonato Junior Raimundo , Bezerra Denilson Da Silva 
Published: January 2019

O objetivo do presente artigo é evidenciar a vulnerabilidade do Maranhão a eventos de secas entre 2010 a 2016. O procedimento metodológico adotado consistiu em uma revisão bibliográfica e de busca de dados/informações em instituições que atuam direta e/ou indiretamente com a temática. Os impactos da seca no Maranhão são de natureza de dificuldade de acesso à água, perdas na agropecuária, perdas de bens materiais, risco à vida humana e perdas de biodiversidade nos biomas e ecossistemas maranhenses. Um impacto que merece destaque são os focos de queimadas, uma vez que os dados e pesquisas existentes indicam que sua ocorrência é modulada por eventos de secas. Palavras-chave: Maranhão. Secas. Impactos. Focos de queimadas.
PENGARUH PEMBERIAN VITAMIN E TERHADAP KADAR PROSTAGLANDIN (PGF2α) DAN TNF α PADA PENDERITA DISMENOREA
Authors: Rishel Rika Astria , Friadi Andi 
Published: January 2019

Pemberian vitamin E pada wanita yang mengalami dismenorea dapat secara langsung menekan kadar ROS dan dapat memperbaiki struktur memberan sel yang rusak. Penelitian ini bertujuan untuk membuktikan pengaruh pemberian vitamin E terhadap kadar Prostaglandin dan TNF-α pada penderita dismenorea. Penelitian ini merupakan quasi eksperimental dengan desain penelitian Pre andPost Test Only Group Designyang menggunakan 22orang wanita yang mengalami dismenorea primer yang derajat 4-6. Pengambilan sampel dengan simple random sampling. Pemeriksaan kadar prostaglandin dan TNF-α dilakukan di UPTD Balai Laboratorium Kesehatan Provinsi Sumatra barat dengan metode ELISA.Hasil penelitian menunjukkan rerata kadar prostaglandin sebelum pemberian Vitamin E yaitu 205,5 ± 143,3 pg/ml, sedangkan setelah pemberian yaitu 124,8 ± 59,0 pg/ml(p<0,05). Rerata kadar TNF-α sebelum pemberian Vitamin E yaitu 207,2 ± 132,0 ng/l, sedangkan setelah pemberian yaitu 125,9 ± 35,7 ng/ll .Pada analisa data didapatkan kadar prostaglandin dan TNF-α p < 0,05. Kesimpulan penelitian ini ada pengaruh pemberian vitamin E terhadap kadar Prostaglandin dan TNF-α pada penderita dismenorea
Автоматичний режим ендовенозного електрозварювання в лікуванні варикозної хвороби нижніх кінцівок
Authors: Horbovets V. S. , Savoluk S. I. , Dyadyk O. O. , Gvozdiak M. M. , Balabai A. A. 
Published: January 2019

Мета. Вивчити ефективність застосування автоматичного режиму ендовенозного електрозварювання (ЕВЕЗ) в лікуванні варикозної хвороби нижніх кінцівок (ВХНК).
Матеріали і методи. Автоматичний режим ЕВЕЗ досліджували на видалених сегментах великої підшкірної вени (ВПВ), визначаючи температуру, опір та морфологічні зміни. Проаналізовані результати застосування методу у 56 пацієнтів з ВХНК С2 - С5 класів (за класифікацією СЕАР - clinic, etiolody, anatоmy, pathogenesis): 21 чоловіка та 35 жінок у віці 18 - 63 років. Критерії оцінки: післяопераційний біль (ПБ), анатомічний результат, ускладнення. Втручання виконували під інфільтраційною анестезією 0,125% розчином бупівакаїну. Результати визначали під час ультразвукового ангіосканування через 14 діб, 3 і 6 міс.
Результати. Протягом автоматичного циклу ЕВЕЗ (5 - 12 с) відбувалася оклюзія ВПВ при температурі 55 - 75 °С. Визначена альтерація вени на глибину ендотеліального та субендотеліального шарів без пошкодження паравазальної клітковини. ПБ був помірний. Фіброзну трансформацію (ФТ) ВПВ через 6 міс встановили у 55 (98,2%) пацієнтів. Екхімози та парестезію спостерігали у 4 (7,1%) та 2 (3,6%) пацієнтів.
Висновки. Автоматичний режим ЕВЕЗ, який ґрунтується на взаємозв’язку електричних параметрів зварювання та опору тканин, забезпечує оклюзію ВПВ з подальшою ФТ, супроводжується низьким нагрівом вени та виключає вплив суб’єктивних факторів на результати операції.
Завершающая склеротерапия рецидивных и резидуальных варикозно расширенных вен нижних конечностей после хирургического и эндовенозных методов лечения
Authors: Musayev V. A. 
Published: January 2019

Цель. Улучшение результатов лечения пациентов с рецидивными и резидуальными варикозно расширенными венами и варикозными узлами нижних конечностей (НК), развившимися после хирургического и эндовенозного лазерного методов лечения.
Материалы и методы. У 32 больных (21 женщины и 11 мужчин) в возрасте от 28 до 71 года выполнили миниинвазивную завершающую склеротерапию рецидивных и резидуальных варикозно измененных вен и варикозных узлов, развившихся после хирургического и эндовенозного лазерного методов лечения в 45 НК.
Результаты. По данным контрольной цветной ультразвуковой допплерографии установлена полная окклюзия подкожных вен и варикозных узлов во всех 45 НК без их реканализации. Транзиторный тромбофлебит развился у 3 пациентов. На чувство инородного тела в виде мелких хорд жаловались 3 пациента, парестезию и ощущение онемения - 2, экхимозы - 2. Эти осложнения не требовали специальных медикаментозных и физиотерапевтических методов лечения и спонтанно разрешились в течение 1 - 6 мес. Выраженных осложнений не наблюдали.
Выводы. У пациентов с неудовлетворительными результатами хирургического лечения хронической венозной недостаточности и варикозных узлов (частота рецидива составляет 48,1%, резидуальной патологии подкожных вен - 25,0%) требуется применение альтернативных миниинвазивных методов лечения. Комплексный подход и правильный выбор эндовенозных лазерных методов лечения позволяют достичь полной окклюзии подкожных вен у 97,37% этих пациентов, сократить частоту возникновения рецидива заболевания и выраженных осложнений до минимума. Больным с реканализацией подкожных вен, а также развитием рецидива и резидуальных явлений в НК целесообразно выполнение завершающей склеротерапии под местной инфильтрационной анестезией в амбулаторных условиях или в стационаре.
Whole genome sequencing of Salmonella Chester reveals geographically distinct clusters, Norway, 2000 to 2016
Authors: Siira Lotta , Naseer Umaer , Alfsnes Kristian , Hermansen Nils Olav , Lange Heidi , Brandal Lin T 
Published: January 2019

Introduction
During summer 2016, Norway observed an increase in Salmonella enterica subsp. enterica serovar Chester cases among travellers to Greece.

Aim
Our aim was to investigate genetic relatedness of S. Chester for surveillance and outbreak detection by core genome multilocus sequence typing (cgMLST) and compare the results to genome mapping.

Methods
We included S. Chester isolates from 51 cases of salmonellosis between 2000 and 2016. Paired-end sequencing (2 × 250 bp) was performed on Illumina MiSeq. Genetic relatedness by cgMLST for Salmonella
enterica subsp. enterica, including 3,002 genes and seven housekeeping genes, was compared by reference genome mapping with CSI Phylogeny version 1.4 and conventional MLST.

Results
Confirmed travel history was available for 80% of included cases, to Europe (n = 13), Asia (n = 12) and Africa (n = 16). Isolates were distributed into four phylogenetic clusters corresponding to geographical regions. Sequence type (ST) ST411 and a single-locus variant ST5260 (n = 17) were primarily acquired in southern Europe, ST1954 (n = 15) in Africa, ST343 (n = 11) and ST2063 (n = 8) primarily in Asia. Part of the European cluster was further divided into a Greek (n = 10) and a Cypriot (n = 4) cluster. All isolates in the African cluster displayed resistance to ≥ 1 class of antimicrobials, while resistance was rare in the other clusters.

Conclusion
Whole genome sequencing of S. Chester in Norway showed four geographically distinct clusters, with a possible outbreak occurring during summer 2016 related to Greece. We recommend public health institutes to implement cgMLST-based real-time Salmonella
enterica surveillance for early and accurate detection of future outbreaks and further development of cluster cut-offs.
Penggunaan Desikan Abu Dan Lama Simpan Terhadap Kualitas Benih Jagung (Zea mays L.) Pada Penyimpanan Ruang Terbuka
Authors: Lesilolo M. K , Patty Jacob , Tetty N. 
Published: January 2019

This study was aimed to determine the proper dose of ash desiccant on maize seed stored for 30, 60 and 90 days. The design used was a Completely Randomized Factorial Design, with two factors and three replications. The first factor was desiccant dose (D) : Do = 0 % (control), D1 = 5 % (12.5 g of seed weight), D2 = 10% (25 g of seed weight), D3 = 15 % (37 g of seed weight), D4 = 20 % (50 %g of seed weight), D5 = 25 % (62.5 g of seed weight). The second factor was length of storage (S) : S1 = 30 day storage, S2 = 60 day storage and S3 = 90 day storage. The result show that use of desiccant only gave effect on the water content of seeds (12.31 %) and speed of seed growth vigor parameters (24.84 %). Use of desiccant in 90 day storage were able to maintain water content of seeds (12.43 %), seed germination viability parameter (100 %), and vigor of seeds, which consisted of seed growth simultaneity (66.77 %) and seed growth speed (28.71 %). The interaction between the use off ash desiccant and the length of storage had no effect on viability and vigor of maize (Zea mays L) seeds but had an effect on their water content after storage (12.73%).
Komunitas Gulma Pada Pertanaman Pala (Myristica fragrans H) Belum Menghasilkan Dan Menghasilkan Di Desa Hutumuri Kota Ambon
Authors: Palijama W , Riry Johan , Wattimena A.Y 
Published: January 2019

Nutmeg (Myristica fragrans H) is native to Indonesia, which has been known as herbal plants. Its planting areas, however, are often hindered by the presence of unwanted plants. Weeds are among the plant pest organisms (PPO), which inhibit the growth, development and productivity of crops. Identification of dominant weed species is the first step in determining the success of weed control. This research was conducted in Hutumury Village, Ambon, with an aim to determine weed species composition and dominant weed species in producing and non producing (juvenile) nutmeg plantations. The process of data collection in the field was undertaken by a survey method. The results showed 18 weed species were found in the plantation of non producing phase and 13 weed species were found in the plantation of producing phase. In the producing plantation, the dominant weed species was Selaginella plana Heron with an SDR value of 57.80%. In the non producing plantation, the dominant weed was also Selaginella plana Heron with an SDR value of 44.42%. The overall dominant weeds in the nutmeg plantations belonged to the annual broad leaf weeds.