bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenomenology of photons-enriched semi-visible jets
Authors: Cazzaniga Cesare , Russo Alessandro , Sitti Emre , de Cosa Annapaola 
Published: November 2024

AbstractThis Letter proposes a new signature for confining dark sectors at the LHC. Under the assumption of a QCD-like hidden sector, hadronic jets containing stable dark bound states originating from hidden strong dynamics, known as semi-visible jets, could manifest in proton-proton collisions. In the proposed simplified model, a heavy $$Z'$$

Z
′

mediator coupling to SM quarks allows the resonant production of dark quarks, subsequently hadronizing in stable and unstable dark bound states. The unstable dark bound states can then decay back to SM quarks via the same $$Z'$$

Z
′

portal or photons via a lighter pseudo-scalar portal (such as an axion-like particle). This mechanism creates a new signature where semi-visible jets are enriched in non-isolated photons. We show that these exotic jets evade the phase space probed by current LHC searches exploiting jets or photons due to the expected high jet neutral electromagnetic fraction and photons candidates non-isolation, respectively. In the proposed analysis strategy to tackle such signature, we exploit jets as final state objects to represent the underlying QCD-like hidden sector. We show that, by removing any selection on the neutral electromagnetic fraction from the jet identification criteria, higher signal efficiency can be reached. To enhance the signal-to-background discrimination, we train a deep neural network as a jet tagger that exploits differences in the substructure of signal and background jets. We estimate that with the available triggers for Run 2 and this new strategy, a high mass search can claim a $$5 \sigma $$

5
σ

discovery (exclusion) of the $$Z'$$

Z
′

boson with a mass up to 5 TeV (5 TeV) with the full Run 2 data of the LHC when the fraction of unstable dark hadrons decaying to photons pairs is around $${30}{\%}$$

30
%

, and with a coupling of the $$Z'$$

Z
′

to SM quarks of 0.25.
Visual political communication on Instagram: a comparative study of Brazilian presidential elections
Authors: de-Lima-Santos Mathias-Felipe , Gonçalves Isabella , Quiles Marcos G. , Mesquita Lucia , Ceron Wilson , Couto Lorena Maria Clara 
Published: November 2024

AbstractIn today’s digital age, images have become powerful tools for politicians to engage with their voters on social media platforms. Visual content possesses a unique emotional appeal that often leads to increased user engagement. However, research on visual communication remains relatively limited, particularly in the Global South. This study aims to bridge this gap by employing a combination of computational methods and qualitative approach to investigate the visual communication strategies employed in a dataset of 11,263 Instagram posts by 19 Brazilian presidential candidates in 2018 and 2022 national elections. Through two studies, we observed consistent patterns across these candidates on their use of visual political communication. Notably, we identify a prevalence of celebratory and positively toned images. They also exhibit a strong sense of personalization, portraying candidates connected with their voters on a more emotional level. Our research also uncovers unique contextual nuances specific to the Brazilian political landscape. We note a substantial presence of screenshots from news websites and other social media platforms. Furthermore, text-edited images with portrayals emerge as a prominent feature. In light of these results, we engage in a discussion regarding the implications for the broader field of visual political communication. This article contributes by showing the ways Instagram was used in the digital political strategy of two fiercely polarized Brazilian elections, shedding light on the ever-evolving dynamics of visual political communication in the digital age. Finally, we propose avenues for future research in the field of political communication.
Solving coupled non-linear schrödinger equations via quantum imaginary time evolution
Authors: Li Yang Hong , Al-Khalili Jim , Stevenson Paul 
Published: November 2024

AbstractCoupled non-linear Schrödinger equations are crucial in describing dynamics of many-particle systems. We present a quantum imaginary time evolution (ITE) algorithm as a solution to such equations in the case of nuclear Hartree-Fock approach. Under a simplified Skyrme interaction model, we calculate the ground state energy of an oxygen-16 nucleus and demonstrate that the result is in agreement with the classical ITE algorithm. We examine bottlenecks and deficiencies in the quantum algorithm and suggest possible improvements.
Pretending to be a VIP! Characterization and Detection of Fake and Clone Channels on Telegram
Authors: La Morgia Massimo , Mei Alessandro , MONGARDINI ALBERTO MARIA , Wu Jie 
Published: November 2024

Telegram is a widely used instant messaging app that has gained popularity due to its high level of privacy protection. Telegram has standout social network features like channels, which are virtual rooms where only administrators can post and broadcast messages to all subscribers. However, these same features have also led to the emergence of problematic activities and a significant number of fake accounts. To address these issues, Telegram has introduced verified and scam marks for channels, but only a small number of official channels are currently marked as verified, and only a few fakes as scams.
In this research, we conduct a large-scale analysis of Telegram by collecting data from 120,979 different public channels and over 247 million messages. We identify and analyze two types of channels: Clones and fakes. Clones are channels that publish identical content from another channel in order to gain subscribers and promote services. Fakes, on the other hand, are channels that impersonate celebrities or well-known services by posting their own messages. To automatically detect fake channels, we propose a machine learning model that achieves an F1-score of 85.45%. By applying this model to our dataset, we find the main targets of fakes are political figures, well-known people such as actors or singers, and services.
Efficacy and Safety of Jiedu Tongluo Therapy for Diabetic Kidney Disease Treatment: A Systematic Review and Meta‐Analysis
Authors: Liu Yuxin , Shang Xiaoling , Wu Hongliang , He Ze 
Published: November 2024

Background: No comprehensive meta‐analysis has evaluated the efficacy and safety of the protective effect of Jiedu Tongluo Therapy on the kidney of DKD until now. This meta‐analysis covers this gap in knowledge.Methods: We have conducted an extensive search of databases, including CNKI, Wanfang, PubMed, and Web of Science. The selection was based on conventional treatment, including information and education on DKD, blood glucose, hypertension control methods, and lifestyle. The control group was composed of conventional western medicine or proprietary Chinese medicine, and the experimental group was composed of Jiedu Tongluo therapy controlled trials (RCTs) between 2003 and 2023. R 4.1.0 software was used to perform statistical analysis.Results: A total of 1871 patients from 19 RCTs were analyzed. Meta‐analysis results showed that the Jiedu Tongluo therapy was effective in improving clinical efficacy (OR = 2.47, 95% CI [1.94, 3.15], I2 = 0%), and these trials were more effective in reducing Scr (MD = −19.81, 95% CI [−27.64, −11.97], p < 0.01), BUN (MD = −0.70, 95% CI [−1.13, −0.27], p < 0.01), UAER (MD = −29.97, 95% CI [−37.33, −22.61], p < 0.01), FBG (MD = −0.85, 95% CI [−1.22, −0.47], p < 0.01), and certain medication safety (OR = 0.75, 95% CI [0.27, 2.11]).Conclusions: For treating diabetic kidney disease, TCM‐based Jiedu Tongluo therapy showed optimal clinical efficacy and safety. However, further rational experiments are needed to validate the above conclusions.
Fungal Influences on Cancer Initiation, Progression, and Response to Treatment
Authors: Bilal Hazrat , Khan Muhammad Nadeen , Khan Sabir , Shafiq Muhammad , Fang Wenjie , Zeng Yuebin , Guo Yangzhong , Li Xiaohui , Zhao Bing , Lv Qiao-Li , Xu Bin 
Published: November 2024

Abstract
Fungal dysbiosis is increasingly recognized as a key factor in cancer, influencing tumor initiation, progression, and treatment outcomes. This review explores the role of fungi in carcinogenesis, with a focus on mechanisms such as immunomodulation, inflammation induction, tumor microenvironment remodeling, and interkingdom interactions. Fungal metabolites are involved in oncogenesis, and antifungals can interact with anticancer drugs, including eliciting potential adverse effects and influencing immune responses. Furthermore, mycobiota profiles have potential as diagnostic and prognostic biomarkers, emphasizing their clinical relevance. The interplay between fungi and cancer therapies can affect drug resistance, therapeutic efficacy, and risk of invasive fungal infections associated with targeted therapies. Finally, emerging strategies for modulating mycobiota in cancer care are promising approaches to improve patient outcomes.
Adverse Birth and Obstetric Outcomes in the Offspring of Male Adolescent and Young Adult Cancer Survivors: A Nationwide Population-Based Study
Authors: Kao Wei-Heng , Chuang Yi-Fang , Huang Yi-Wei , Chen Po-Jui , Liu Yu-Cheng , Wang Chun-Chieh , Hsu Jun-Te , Shueng Pei-Wei , Kuo Chang-Fu 
Published: November 2024

Abstract

Background:
The growing population of male adolescent and young adult (AYA, ages 15–40 years) cancer survivors has heightened interest in their reproductive health. However, studies have reported conflicting findings on the potential risks of cancer and its treatments on birth and obstetric outcomes.

Methods:
We used encrypted identification numbers for both fathers and mothers to link three nationwide Taiwan datasets from 2004 to 2019, identifying 3,785 births with a paternal history of AYA cancer. For comparison, we included 37,850 matched fathers without a cancer history, matched by paternal age and infant birth year. We used multivariable logistic regression analysis to identify independent associations between adverse birth outcomes (e.g., preterm labor, low birthweight, and congenital malformations) and obstetric outcomes (e.g., fetal growth restriction, threatened labor, and threatened abortion) and being born to male AYA cancer survivors.

Results:
The offspring of male AYA cancer survivors did not exhibit a significantly increased risk of adverse birth (OR = 1.0; 95% confidence interval, 0.9−1.1) or obstetric (OR = 1.1; 95% confidence interval, 1.0−1.1) outcomes compared with offspring born to cancer-free matched fathers. Furthermore, the risk of preterm labor, low birthweight, congenital malformations, fetal growth restriction, and threatened labor or miscarriage was comparable between groups.

Conclusions:
Paternal cancer history during adolescence or young adulthood does not seem to increase the risk of adverse birth or obstetric outcomes in offspring.

Impact:
This study reassures the reproductive health of this population, providing valuable insights for oncology and reproductive medicine, potentially influencing patient counseling and guidelines.
Targeting CDK7 Enhances the Antitumor Efficacy of Enzalutamide in Androgen Receptor–Positive Triple-Negative Breast Cancer by Inhibiting c-MYC–mediated Tumorigenesis
Authors: Xie Xuemei , Manai Maroua , Rampa Dileep R. , Fuson Jon A. , Nakasone Elizabeth S. , Pearson Troy , Kuntal Bharat S. , Tripathy Debu , Ueno Naoto T. , Lee Jangsoon 
Published: November 2024

Abstract
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Among TNBC subtypes, the luminal androgen receptor (LAR) subtype expresses high levels of androgen receptor (AR) and generally responds poorly to neoadjuvant chemotherapy. AR has been reported as a promising therapeutic target for the LAR TNBC subtype. In this study, we evaluated the preclinical antitumor efficacy of enzalutamide, an AR inhibitor, in TNBC. Enzalutamide had moderate antiproliferative activity against AR-positive (AR+) TNBC cells (IC50 &gt; 15 μmol/L). To enhance its antitumor efficacy, we performed high-throughput kinome RNAi screening and identified the cell cycle pathway as a potential target. Inhibition of cell cycle progression using the cyclin-dependent kinase 7 inhibitor KRLS-017 showed a synergistic antiproliferative effect with enzalutamide in AR+ LAR MDA-MB-453 and SUM185 TNBC cells. Downstream target analysis revealed that the enzalutamide and KRLS-017 combination dramatically reduced c-MYC expression at both mRNA and protein levels. c-MYC knockdown significantly suppressed growth of MDA-MB-453 and SUM185 cells to a degree comparable with that of enzalutamide and KRLS-017 combination treatment, whereas c-MYC overexpression reversed the synergistic effect. An enhancement in inhibition of tumor growth and suppression of c-MYC expression was further confirmed when enzalutamide was combined with KRLS-017 in an MDA-MB-453 mouse model. Our study suggests that KRLS-017 enhances the antitumor efficacy of enzalutamide by inhibiting c-MYC–mediated tumorigenesis and presents a potential new approach for treating AR+ LAR TNBC.
Total (Immuno)Therapy: Version 2.0
Authors: Bal Susan , Costa Luciano J. 
Published: November 2024

Summary:
Among patients with poly-refractory myeloma, autologous chimeric antigen receptor T-cell therapy offers exceptional promise. With the availability of bispecific antibodies, a total immunotherapeutic strategy in combination with chimeric antigen receptor T-cell therapy is now feasible.
See related article by Fandrei et al., p. 38
Disruption of PCSK9 Suppresses Inflammation and Attenuates Abdominal Aortic Aneurysm Formation
Authors: Peng Zekun , Lv Shuang-Jie , Chen Hong , Rao Haojie , Guo Ziyi , Wan Qing , Yang Jianfeng , Zhang Yuze , Liu De-Pei , Chen Hou-Zao , Wang Miao 
Published: November 2024

BACKGROUND:
Abdominal aortic aneurysm (AAA) is a chronic vascular inflammatory disease without effective medications. PCSK9 (proprotein convertase subtilisin/kexin 9), a serine protease from the proprotein convertase family, has recently been associated with AAA in human genome-wide association studies. However, its role in AAA is unknown.

METHODS:
Transcriptional and histological expression of PCSK9 was examined in AAA tissues and healthy controls. The impact of PCSK9 deletion and inhibition on AAA formation was assessed in mice with hyperlipidemia and Ang II (angiotensin II) overproduction. AAA lesion morphology was assessed by tissue staining. MMP (matrix metalloproteinase) activity was evaluated by gelatin zymography, and leukocyte-vessel wall interaction was monitored by intravital microscopy. RNA sequencing was used to characterize the downstream signaling of PCSK9.

RESULTS:

PCSK9 expression was upregulated and colocalized with macrophages in human and mouse AAAs.
Pcsk9
deletion attenuated AAA formation, improved survival, and decreased systemic inflammation, without altering circulating cholesterol levels.
Pcsk9
deficiency reduced aortic infiltration of macrophages and elastin degradation, without affecting vascular smooth muscle cell apoptosis and proliferation. Mechanistically, PCSK9 was essential in leukocyte-endothelium adhesion and expression of proinflammatory cytokines and MMP9 by macrophages. RNA sequencing of stimulated macrophages revealed that
Pcsk9
deficiency upregulated histone deacetylase SIRT1 (sirtuin-1) and suppressed NF-κB (nuclear factor-κB) inflammatory signaling. SIRT1 inhibition attenuated the proinflammatory actions of PCSK9. Furthermore, administration of PCSK9 small interfering RNA or antibody constrained AAA formation/progression and inhibited vascular inflammation.

CONCLUSIONS:
PCSK9 critically mediates macrophage inflammation and elastin degradation, promoting AAA formation. PCSK9 inhibitors bear a promise to curtail AAA, beyond being used as cholesterol-lowering drugs.
The function of putative appeasement behaviour for access to food in African painted dogs
Authors: Ake Kanako , Kutsukake Nobuyuki 
Published: November 2024

Abstract
In some group-living species that share food, interindividual disagreement on access to food is mediated by several types of negotiation, ranging from appeasing the current owner to reduce aggression and gain access to the food, to harassment where non-owners assert their presence and apply insistent pressure until owners give up their food. In some species, non-owners employ specific behaviours used in other social contexts during negotiation, which makes it challenging to discern their precise functions. The core prediction of the harassment hypothesis is that intense pressure by beggars makes owners abandon their food and leads to food monopolisation, which is not predicted by the appeasement hypothesis. In the African painted dog (Lycaon pictus), non-owners assume a low posture and produce high-pitched vocalisations — a suite of behaviours considered appeasement in non-feeding contexts. This study examined whether these behaviours, referred to collectively as putative appeasement behaviour (PAB), serve as appeasement in the context of feeding or whether they may also, or only, be used for harassment. To this end, we used behavioural experiments in captive parent–offspring or full sibling pairs. Individuals showed more frequent PAB when offered food that could not be easily shared (one vs. two bones). As aggression also only occurred under that condition, PAB seems to have a function in appeasement. However, we observed a positive effect of PAB on food monopolisation by PAB actors but not on co-feeding. Persistent PAB led to monopolisation, indicating that these behaviours serve as a form of harassment in feeding. We did not observe reciprocity between paired individuals, another possible form of food monopolisation besides appeasement and harassment. In conclusion, PAB in the African painted dog functions as both appeasement and harassment, and this highly tolerant species employs negotiation strategies in feeding.
Adverse Effects of Covid-19, Globalization and Modern Day Slavery: Towards Interdependence, Solidarity and Radical Hospitality
Authors: Longkumer Bendanglemla 
Published: November 2024

Abstract
The Covid-19 pandemic has made a significant impact on the world: its effects are not evenly distributed. For those who are vulnerable to being categorized as victims of modern-day slavery, the socio-economic disruption caused by the Covid-19 pandemic affected their lives in new and profound ways. It has aggravated their vulnerabilities and exposed systemic injustices. Examples of such can be found in the ongoing struggles of migrant workers. What might be appropriate theological reflections? This article aims to explore the adverse effects of Covid-19 pandemic, and the problems underlying the nexus of globalization and slavery (in various forms). The effects of the Covid-19 pandemic on the vulnerable sections of the people, which is understood as modern slavery. The task of a public Christian vocation in such circumstances is one of assessing what has happened and then affirming the interdependence and interconnectedness of the human community, solidarity and radical hospitality.
Decolonising Biblical Theology: Towards Postcolonial Biblical Theology in the Public Sphere of Indonesia
Authors: Setyawan Yusak Budi 
Published: November 2024

Abstract
This article presents the main argument that in the Indonesian context, biblical theology should be able to play a crucial role not only in the church and academic spheres but also, and more importantly, in the wider society by overturning the hegemony of colonialism in biblical theology and developing postcolonial biblical theology in the actual context of Indonesia. In undergirding this argument, the article first puts forward the situation of biblical theology in scientific and societal discourse in general and in the Indonesian context in particular. The findings in this analysis are followed by an explanation of the importance of developing a horizon in elaborating biblical theology in the Indonesian context informed by seven distinguishing public issues in Indonesian society. Biblical theology must be encouraged to penetrate the public sphere. In elaborating on biblical theology in the Indonesian context, postcolonial studies are highly significant in connecting biblical theology and the Indonesian context.
Bonhoeffer on the Public Role of the Church – a View from the Contemporary Brazilian Political and Religious Scenario
Authors: Caldas Carlos 
Published: November 2024

Abstract
A religious phenomenon that has been observed by many religious researchers in the last years is the numerical growth of the Evangelical population in Brazil. The vast majority of this expression of the Christian faith is formed by Pentecostals and Neopentecostals. With this massive growth, the Evangelical presence in Brazilian society is more and more visible, especially inasmuch as Evangelicals are getting more involved in politics. This article aims to analyze the public presence of the Evangelical Brazilian church in society from the perspective of the ecclesiology of Dietrich Bonhoeffer. The article presents first Bonhoeffer’s ecclesiology. Then, it presents Bonhoeffer’s understanding of the church’s role in the world. The last part of the article brings considerations on public theology and two practical points from Bonhoeffer’s theology that are of the highest importance for the Brazilian Evangelical church – preaching and the defence of human rights.
Towards Expansive Justice for Animals: Holmgren’s Permaculture for Deane-Drummond’s Animal Ethics
Authors: Bierma Troy 
Published: November 2024

Abstract
Celia Deane-Drummond has argued that natural law implies an expansion of social justice to protect animal needs and agency. Her argument is valid but lacks an approach for guiding ethical activity. As such, this article contributes to the concerns of public theology by drawing on resources from the ethical and design principles of David Holmgren’s permaculture. I attempt to narrow the gap in ecotheology between justice as a virtue in theory and justice as an ethical activity. I argue that permaculture practice is an exemplary way of seeking the sort of justice for animals for which Deane-Drummond has argued. As an holistic environmental practice, permaculture prompts ecotheology to consider it seriously as a context for ethical activity and for ethical reflection and, in turn, prompts questions for ecotheological reflection.
Is Pope Francis a Marxist?
Authors: Lok Peter Wing Kai 
Published: November 2024

Abstract
Pope Francis has been widely portrayed by the popular media as a ‘revolutionary left-wing’ Pope, owing to his open stance on same-sex relationships and his harsh criticism of capitalism. His South American background has also led the media to casually associate him with the tradition of liberation theology, whose methodology is deeply influenced by Marxism. In this article, I argue that Pope Francis’s public theology is neither a Marxist theology nor a liberation theology, as some critics have suggested. In contrast, his theology is an assemblage of the critical heritage of Catholic social thought, Franciscan theology of the poor, Argentine theology of the people, and Ignatian pastoral theology.