bluuebunny/crossref_metadata_2025_split huggingface dataset:
Violence risk prediction in mental health inpatient settings using the Dynamic Appraisal of Situational Aggression
Authors: Moscovici Mario , Farrokhi Farhat , Vangala Lavanya , Simpson Alexander I. F. , Kurdyak Paul , Jones Roland M. 
Published: December 2024

Introduction/BackgroundAggression and violence are common problems in healthcare settings and affects both patients and healthcare staff. The Dynamic Appraisal of Situational Aggression (DASA) is an assessment tool to guide assessment for short term risk in inpatient settings. There have been no large-scale studies examining the performance of the DASA across different clinical settings. Our objective is to examine the performance of the DASA using a large longitudinal patient sample on different clinical units. A secondary objective was to examine alterative risk categories of the DASA.MethodsAll consecutive mental health hospital admissions to a large hospital in Toronto, Canada between 2016 and 2019 were included. Time-to-event analysis and Receiver Operating Characteristics Area Under the Curve (AUC) was conducted with the outcome variable being the occurrence of the first violent incident or first restraint event.ResultsWe included 3819 patients, of which 17% had at least one violent incident. We analysed 88,124 DASA scores and found a significant association with violence (HR 1.79 (95% CI), AUC 0.73). We found that the AUCs were similar for subspecialized forensic, schizophrenia and acute care units (0.71, 0.73 and 0.75 respectively), and lower for geriatric units (0.66). We propose new violence risk categories based on the frequency of violence at each score.DiscussionHigher DASA scores are associated with higher risk of violent incidents in both forensic and non-forensic inpatient psychiatric units. The proposed violence risk groups help rule out patients at low risk of violence and may help identify patients who would most benefit from interventions to reduce violence.
An innovation bootcamp model for developing youth-led HIV self-testing delivery strategies in Nigeria: post-designathon capacity building
Authors: Nwaozuru Ucheoma , Obiezu-Umeh Chisom , Tahlil Kadija M. , Gbaja-Biamila Titilola , BeLue Rhonda , Idigbe Ifeoma , Oladele David , Conserve Donaldson , Airhihenbuwa Collins , Xian Hong , Musa Adesola Z. , Olusanya Olufunto , Ojo Temitope , Ezechi Oliver , Tucker Joseph D. , Iwelunmor Juliet 
Published: December 2024

IntroductionMany designathons, hackathons, and similar participatory events suffer from minimal training and support after the events. Responding to this need, we organized a health innovation bootcamp: an intensive, team-based apprenticeship training with research and entrepreneurial rigor among young people in Nigeria to develop HIV self-testing (HIVST) delivery strategies for Nigerian youth. The purpose of this paper was to describe an innovation bootcamp that aimed to develop HIVST delivery strategies for Nigerian youth.MethodsThe four-week, in-person innovation bootcamp, informed by youth participatory action research and comprised a series of workshops, took place in Lagos, Nigeria. The goal was to build research and entrepreneurial capacities among young people to develop and implement HIVST strategies. A qualitative content analysis informed by an adapted World Health Organization’s HIVST delivery framework explored key elements of the proposed HIVST service delivery strategies developed at the bootcamp.ResultsTwenty participants, aged 18–24 years, from five teams completed the innovation bootcamp. The five teams developed HIV service delivery strategies that included an element of repacking HIVST kits to make them more appealing to young people. Other strategies that emerged included leveraging community engagement platforms (e.g., vocational skills training and youth community events) to promote HIVST, and the use of reward-referral system to encourage HIVST uptake among young people. All strategies included ways to ensure privacy protection for recipients of the HIVST delivery package.ConclusionThis study demonstrated the feasibility and acceptability of the health innovation bootcamp model to create HIVST designed for and led by young people. This suggests a way to build capacity after participatory events to sustain youth-led research, which could have implications for post-designathon training.
Digital health literacy and use of patient portals among Spanish-preferred patients in the United States: a cross-sectional assessment
Authors: Philpot Lindsey M. , Ramar Priya , Roellinger Daniel L. , McIntee Margaret A. , Ebbert Jon O. 
Published: December 2024

ObjectiveIndividuals with Limited English Proficiency (LEP), including Spanish-preferred patients, face healthcare challenges due to language barriers. Despite the potential of digital health technologies to improve access and outcomes, there is a “digital divide” with underutilization among vulnerable populations, including Spanish-speaking LEP individuals, highlighting a need for increased understanding and equitable digital health solutions.Materials and methodsA multi-mode, multi-language cross-sectional survey was built based on the Technology Acceptance Model and deployed from a multi-state healthcare practice. Measures included patient-reported comfort level with reading and speaking English, internet and computer access and satisfaction, ability to perform healthcare-related online tasks, and the eHEALS scale of digital health literacy.ResultsA total of 212 Spanish-preferred patients completed the survey (response rate, 212/2,726 = 7.8%), of which 73.6% indicated lack of comfort in reading or writing in English (LEP n = 156). Spanish-speaking individuals with LEP reported higher rates of needing help when learning how to use new technology or devices, reporting difficulty in the evaluation of health information on the internet and being able to differentiate high-quality information from low-quality online health resources, feeling confident in using health information found online to make health decisions, and having lower access to health-related online services than Spanish-speaking individuals without LEP.DiscussionImproving equitable accessibility to digital tools for individuals with LEP seeking healthcare can help to improve their engagement with their providers and promote self-efficacy in their care. Opportunities exist with emerging technologies to develop language-concordant healthcare resources that will improve outcomes for Spanish-preferred patients.
Antibiotic susceptibility testing and molecular characterization based on whole-genome sequencing of Streptococcus pneumoniae isolates from pediatric infections at the National Regional Medical Center of Southwest China during the COVID-19 pandemic
Authors: Yan Ziyi , Miao Chenglin , Liu Li , Fu Yunhan , Liu Xingxin , Li Hong , Kuang Linghan , Cui Yali , Jiang Yongmei 
Published: December 2024

BackgroundStreptococcus pneumoniae is a transmitted respiratory pathogen that causes high morbidity and mortality in children, especially those under 5 years of age. During the implementation of population control measures for COVID-19 in mainland China, the Streptococcus pneumoniae detection rate in pediatric patients decreased. However, with the second wave of the COVID-19 pandemic (2022), the incidence of pneumococcal disease (PD) and even invasive pneumococcal disease (IPD) began to rise again.MethodsThis study was conducted from August 2022 to September 2023 at a national regional medical center based mainly in West China Second University Hospital, Sichuan University. The demographic and clinical characteristics of S. pneumoniae-infected pediatric patients were analyzed. All S. pneumoniae isolates were subjected to standardized clinical sample inoculation, culture, subculture, and identification procedures. Next-generation sequencing and analysis were used to determine serotypes and sequence types (STs) and evaluate antibiotic resistance- and virulence-related genes. Antimicrobial susceptibility was determined in AST dishes via the broth microdilution method.ResultsThe prevalent serotypes in the IPD patients were 14, 6A, and 23F, and the prevalent serotypes in the NIPD patients were 19F and 6A. A significant difference in the proportion of patients with serotype 14 was noted between the two groups. A total of 23 STs were identified and classified into 13 different GPSC lineages, including 4 novel STs (ST18449, ST18451, ST18464 and ST18466) and 1 novel allele (ddl1209). According to the interpretation breakpoints for non-meningitis infections, the resistance/nonsusceptibility rates of invasive isolates were as follows: penicillin (0.0%/8.3%), amoxicillin (0.0%/0.0%), cefotaxime (8.3%/16.6%), ceftriaxone (8.3%/8.3%), and cefepime (0.0%/8.3%). The resistance/nonsusceptibility rates of invasive isolates according to the meningitis breakpoints were as follows: penicillin (100.0%), cefotaxime (16.7%/33.4%), ceftriaxone (8.3%/50.0%), and cefepime (8.3%/66.7%). All the isolates were susceptible to rifampicin, levofloxacin, moxifloxacin, linezolid and vancomycin. In addition, the characteristics of the antibiotic resistance-related genes and virulence genes of serotype 19F were significantly different from those of the other serotypes.ConclusionThese data provide valuable information for understanding pediatric pneumococcal disease during the second outbreak of COVID-19 in Southwest China and will contribute to the prevention and treatment of S. pneumoniae infection.
Respiratory chronic health conditions and racial disparities associated with e-cigarette use: a cross-sectional analysis using behavioral risk factor surveillance data
Authors: Comiford Ashley , Pan Steven , Chen Sixia 
Published: December 2024

BackgroundChronic Obstructive Pulmonary Disease (COPD), mainly caused by cigarette smoking, is one of the leading causes of death in the United States (US) and frequent asthma attacks are often exacerbated by cigarette use. Electronic cigarettes (e-cigarettes) are often used to quit cigarette smoking. Prevalence of COPD, asthma, cigarette use, and e-cigarette use differs between racial/ethnic groups. The overall objective was to assess the associations between e-cigarette use and COPD and asthma and how race/ethnicity and cigarette smoking modifies these associations.MethodsData were retrieved from the 2016–2018 and 2020–2021 Behavioral Risk Factor Surveillance System datasets, a national annual health survey representing the US general adult population. Frequency and weighted percentages or means and standard deviations were obtained. Rao-Scott Chi-square test, two-sample t tests, and logistic regression were used to evaluate binary associations between current e-cigarette use and lifetime diagnosis of COPD and asthma. Multivariable analyses using logistic regression were conducted to assess associations between variables. Interaction effects between e-cigarette use and race/ethnicity were assessed and stratified analyses were performed as indicated. All multivariate analyses were stratified by cigarette smoking status.ResultsPrevalence of e-cigarette use was 5.1%, COPD was 6.7%, and asthma was 9.2%. Individuals who currently smoked cigarettes among all racial/ethnic groups, excluding non-Hispanic (NH) American Indian/Alaska Native individuals, were more likely to report current asthma if using e-cigarettes compared to non-use (p &lt; 0.05). Among individuals who never smoked, Non-Hispanic White (NHW), NH-Black and Hispanic individuals using e-cigarettes had greater odds of COPD compared to NHW, NH-Black and Hispanic individuals who did not use these products, respectively (p &lt; 0.05). Among NHW, Hispanic, and NH-Other persons who currently used cigarettes, individuals currently using e-cigarettes had greater odds of COPD compared to NHW, Hispanic, and NH-Hispanic individuals who did not use e-cigarettes, respectively (p &lt; 0.05). Among individuals who formerly used cigarettes, current e-cigarette use was associated with COPD and asthma. Among individuals who never used cigarettes, current e-cigarette use was associated with reporting current asthma.ConclusionThe association between e-cigarette use and COPD and asthma was dependent on smoking status and racial/ethnic groups. Further studies should be conducted to explore this association.
Intramuscular stiffness distribution in anterior and posterior upper trapezius muscles in healthy young males
Authors: Sasaki Kohei , Miyamoto Naokazu 
Published: December 2024

IntroductionIncreased muscle stiffness in the upper trapezius has been suggested to be associated with cervical myofascial pain and myofascial trigger points (MTrP). Recently, efforts have been made to objectively detect MTrP using ultrasound shear wave elastography (SWE). However, there is no consensus on the relationship between muscle stiffness assessed by SWE and MTrP. This may be due to the possibility that muscle stiffness is not uniform even in the asymptomatic trapezius. The present study aimed to characterize passive muscle stiffness at the proximal, central, and distal sites of the anterior and posterior parts of the upper trapezius.MethodsSeventeen healthy young males without neck pain participated in the study. The upper trapezius was divided into anterior and posterior parts based on anatomical landmarks: the line between C6 and the lateral end of the clavicle was defined as the anterior part, while the line between C7 and the acromion angle was defined as the posterior part. Shear wave speed (SWS; an index of stiffness) was measured using ultrasound SWE at six sites in the anterior and posterior parts of the upper trapezius, at 25% (proximal), 50% (central), and 75% (distal) of the muscle belly length.ResultsSWS in the anterior part was significantly higher at the proximal (p &lt; 0.001) and distal (p &lt; 0.001) sites than at the central site. In the posterior part, there was no significant difference in SWS between the proximal, central, and distal sites. Comparisons between the anterior and posterior parts showed no significant differences in SWS at the proximal (p = 0.147), central (p = 0.339), and distal sites (p = 0.051).ConclusionsThe characteristics of passive stiffness distribution in the anterior and posterior parts of the upper trapezius have important implications with respect to the optimal location of the control point during MTrP detection. In particular, it may be preferable to set the control point for detecting MTrP in the transverse direction rather than in the fascicle direction, that is, to compare passive muscle stiffness at the same levels between the anterior and posterior parts.
An analysis of different modalities of bone mineral densitometry evaluation in cage subsidence in anterior cervical discectomy and fusion
Authors: Yu Qingsong , Chen Jiabao , Wang Haidong , Ma Lei 
Published: December 2024

ObjectiveTo compare the effectiveness of different measurement methods on bone miner density (BMD), including cervical HU of CT, MRI-based cervical vertebral bone quality (C-VBQ), and T value of DEXA, for predicting cage subsidence after single-level ACDF.MethodsThis is a retrospective study, and patients who underwent single-level ACDF from June 2019 to June 2022 were recruited. We collected preoperative total segmental vertebral height (pre-TSVH), cage subsidence height, cervical angle (CA), T1-slope, straight or reverse cervical curvature, mean HU value of C3–7 (C-HU), mean HU of segment (seg-HU), C-VBQ, segmental C-VBQ (seg-VBQ), and total lumbar T value (T value). The variables between the two groups were compared by Student's t test or chi-square test. Logistic regression was used to determine the independent risk factors for subsidence. The ROC curve was used to analyze the predictive efficiency of C-HU, seg-HU, C-VBQ, seg-VBQ and T value for cage subsidence. Finally, the correlations of C-HU, seg-HU, C-VBQ, seg-VBQ, T value and subsidence height were analyzed.ResultsA total of 320 patients were included in this study, and 97 patients (30.31%) had cage subsidence at the last follow-up. The subsidence height was 4.25 ± 0.937 mm in the subsidence group and 1.40 ± 0.726 mm in the nonsubsidence group. There were statistically significant differences between the two groups in bone mineral density-related indexes, including C-HU, seg-HU, C-VBQ, seg-VBQ, and T value (p &lt; 0.05). Logistic regression analysis showed that C-HU was an independent risk factor for vertebral subsidence after single-level ACDF. ROC curve analysis showed that C-HU had the largest AUC of 0.897 (0.862, 0.933) in predicting vertebral subsidence. Correlation analysis showed that C-HU had a high correlation with the T value (r = 0.662, p &lt; 0.001), while C-VBQ had a low correlation with the T value (r = −0.173, p = 0.002), and C-VBQ had a low correlation with subsidence height (r = 0.135, p = 0.016).ConclusionOur study showed that compared with the C-VBQ and T value, C-HU is more effective for predicting cage subsidence after ACDF. Using the segmental index of C-VBQ or HU could not improve predictive effectiveness. C-VBQ may be insufficient in predicting cage subsidence and estimating BMD.
Influence of maternal nutrition and one-carbon metabolites supplementation on bovine antimicrobial peptides in fetal and maternal tissues
Authors: Daneshi Mojtaba , Borowicz Pawel P. , Hirchert Mara R. , Entzie Yssi L. , Syring Jessica G. , King Layla E. , Safain Kazi Sarjana , Anas Muhammad , Reynolds Lawrence P. , Ward Alison K. , Dahlen Carl R. , Crouse Matthew S. , Caton Joel S. 
Published: December 2024

IntroductionMaternal nutrition during pregnancy critically influences offspring development and immune function. One-carbon metabolites (OCM) are epigenetic modifiers that may modulate antimicrobial peptide (AMP) expression, which is vital for innate immunity. This study investigated the effects of maternal nutrient restriction and OCM supplementation on mRNA expression of AMP in fetal and maternal lung, mammary gland, and small intestine of beef cattle.MethodsTwenty-nine crossbred Angus beef heifers were synchronized for estrus and artificially inseminated. They were assigned to one of four treatments in a 2 × 2 factorial design: nutritional plane [control (CON) vs. restricted (RES)] and OCM supplementation [without OCM (−OCM) or with OCM (+OCM)]. Heifers on the CON diet were fed to gain 0.45 kg/day, while RES heifers were fed to lose 0.23 kg/day. Treatments were applied from day 0 to 63 of gestation, after which all heifers were fed a common diet to gain 0.45 kg/day until day 161 of gestation, when samples were collected. Quantitative RT-qPCR was used to assess mRNA expression of AMP.ResultsNutritional plane had no effect (p ≥ 0.24) on mRNA expression of AMP in either the fetus or dams. However, the mRNA expression of cathelicidin5 (CATHL5; p = 0.07) and bovine neutrophil β-defensin5 (BNBD5; p = 0.07) in the fetal lung and mammary gland, respectively, was lower in the +OCM groups compared to the −OCM groups. In the maternal small intestine, the expression of enteric β-defensin (EBD) was lower (p = 0.01) in the +OCM groups compared to the −OCM groups. Additionally, in the maternal lung, there was a tendency (p = 0.06) for an interaction in CATHL5 mRNA expression, with the RES + OCM group showing greater expression compared to the CON + OCM (p = 0.07) and RES − OCM (p = 0.08) groups.DiscussionOur findings suggest that while restricted maternal nutrition did not affect mRNA expression of AMP, OCM supplementation modulated AMP expression in both fetal and maternal tissues. Further research is needed to elucidate the mechanisms underlying OCM’s impact on AMP expression.
VALIDITY OF SPARKOL VIDEOSCRIBE BASED ANIMATED VIDEO FOR HANDLING UNDERNUTRITION IN TODDLERS
Authors: Harefa Wiwien Ellora Ester Riang , Mulyani Sri , Andayani Tri Rejeki 
Published: December 2024

Gizi kurang merupakan suatu kondisi balita tidak mencapai berat badan ideal, yang bisa memengaruhi pertumbuhan tinggi badan, Berbagai upaya dapat dilakukan untuk menangani antara lain dengan memberikan edukasi gizi melalui media video animasi. Penelitian ini bertujuan untuk mengembangkan materi edukasi berupa video animasi berbasis Sparkol Videoscribe untuk membantu menangani masalah gizi kurang pada balita. Penelitian ini menggunakan metode Reasearch and Development yang mengacu pada kerangka kerja ADDIE meliputi (Analyze, Design, Development, Implementation, dan Evaluation). Validasi video animasi berbasis Sparkol videoscribe melibatkan 3 ahli yaitu ahli materi, ahli bahasa, dan ahli media. Selanjutnya dilakukan uji coba (sampel terbatas n = 10) pada ibu balita gizi kurang. Pemilihan sampel menggunakan teknik purposive sampling. Metode rancangan quasi expeimental dengan desain nonequivalent control group dan dampak penggunaan video diukur dengan tiga alat ukur, yaitu: kuesioner pengetahuan gizi (reliabilitasnya 0,71), kuesioner efikasi diri (reliabilitasnya=0,95), kuesioner pola asuh makan (reliabilitasnya=0,95). Hasil penelitian menunjukkan media video animasi berbasis Sparkol Videoscribe untuk menangani masalah balita gizi kurang dinilai layak dengan skor rata–rata dari ahli materi 84%, ahli bahasa 86,6% dan ahli media 86%, hasil uji coba video animasi dengan small group dihasilkan 85,5% dengan kategori sangat layak dan hasil uji coba kuesioner menunjukkan ada peningkatan pengetahuan gizi, efikasi diri dan pola asuh makan dengan kategori sedang. Kesimpulannya media video animasi berbasis Sparkol Videoscribe yang dikembangkan dalam penelitian dapat diterapkan untuk membantu menangani masalah gizi kurang pada balita.
ВОЗМОЖНОСТИ ЭЛЕКТРОМЕТРИЧЕСКОГО МОНИТОРИНГА ДЛЯ ОПРЕДЕЛЕНИЯ ОРЕОЛОВ РАСПРОСТРАНЕНИЯ ИЗБЫТОЧНЫХ РАССОЛОВ В ПРЕДЕЛАХ ПОЛИГОНОВ ЗАКАЧКИ
Authors: А.А. Тайницкий , Р.А. Богданов , Ю.И. Степанов , Е.С. Зубрикова , М.С. Лучников 
Published: December 2024

В статье представлены результаты мониторинговых электрометрических наблюдений методом вертикального зондирования (ВЭЗ), выполненных одновременно с закачкой избыточных рассолов высокой минерализации в надсолевые породы. Для сокращения количества шламохранилищ и снижения их негативного воздействия на окружающую среду современные компании прорабатывают возможность безопасно размещать и утилизировать избыточные рассолы в подземных горизонтах-коллекторах. Однако важно проводить контроль над распространением рассолов для оценки техногенной нагрузки на подземные воды. Таким образом, электроразведочные мониторинговые наблюдения выполнялись для определения ореола распространения рассолов в зоне активного водообмена и оценки засоления подземных вод до глубины 170 м.
To reduce the number of sludge storage facilities and reduce their negative impact on the environment, modern companies are exploring the possibility of safely placing and disposing of excess brines in underground reservoirs. However, it is important to monitor the spread of brines to assess the anthropogenic load on groundwater. The article presents the results of monitoring electrometric observations using the vertical electrical sounding (VES) method, performed simultaneously with the injection of excess brines of high mineralization into the well. Observations were carried out to determine the halo of brine distribution in the zone of active water exchange and to assess the salinity of groundwater to a depth of 170 meters.