bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Subset of Mesotheliomas With Improved Survival Occurring in Carriers ofBAP1and Other Germline Mutations
Authors: Pastorino Sandra , Yoshikawa Yoshie , Pass Harvey I. , Emi Mitsuru , Nasu Masaki , Pagano Ian , Takinishi Yasutaka , Yamamoto Ryuji , Minaai Michael , Hashimoto-Tamaoki Tomoko , Ohmuraya Masaki , Goto Keisuke , Goparaju Chandra , Sarin Kavita Y. , Tanji Mika , Bononi Angela , Napolitano Andrea , Gaudino Giovanni , Hesdorffer Mary , Yang Haining , Carbone Michele 
Published: October 2018

PurposeWe hypothesized that four criteria could help identify malignant mesotheliomas (MMs) most likely linked to germline mutations of BAP1 or of other genes: family history of MM, BAP1-associated cancers, or multiple malignancies; or age younger than 50 years.Patients and MethodsOver the course of 7 years, 79 patients with MM met the four criteria; 22 of the 79 (28%) reported possible asbestos exposure. They were screened for germline BAP1 mutations by Sanger sequencing and by targeted next-generation sequencing (tNGS) for germline mutations in 55 additional cancer-linked genes. Deleterious mutations detected by tNGS were validated by Sanger sequencing.ResultsOf the 79 patients, 43 (16 probands and 27 relatives) had deleterious germline BAP1 mutations. The median age at diagnosis was 54 years and median survival was 5 years. Among the remaining 36 patients with no BAP1 mutation, median age at diagnosis was 45 years, median survival was 9 years, and 12 had deleterious mutations of additional genes linked to cancer. When compared with patients with MMs in the SEER cohort, median age at diagnosis (72 years), median survival for all MM stages (8 months), and stage I (11 months) were significantly different from the 79 patients with MM in the current study ( P < .0001).ConclusionWe provide criteria that help identify a subset of patients with MM who had significantly improved survival. Most of these patients were not aware of asbestos exposure and carried either pathogenic germline mutations of BAP1 or of additional genes linked to cancer, some of which may have targeted-therapy options. These patients and their relatives are susceptible to development of additional cancers; therefore, genetic counseling and cancer screening should be considered.
Preoperative Echocardiography for Patients With Hip Fractures Undergoing Surgery: A Retrospective Cohort Study Using a Nationwide Database
Authors: Yonekura Hiroshi , Ide Kazuki , Onishi Yoshika , Nahara Isao , Takeda Chikashi , Kawakami Koji 
Published: October 2018

BACKGROUND:
The effect of preoperative transthoracic echocardiography on the clinical outcomes of patients with hip fractures undergoing surgical treatment remains controversial. We hypothesized that preoperative echocardiography is associated with reduced postoperative morbidity and improved patient survival after surgical repair of hip fractures.

METHODS:
Drawing from a nationwide administrative database, patients undergoing hip fracture surgeries between April 1, 2008 and December 31, 2016 were included. We examined the association of preoperative echocardiography with the incidence of in-hospital mortality using propensity score matching. Secondary outcomes included postoperative complications, the incidence of postoperative intensive care unit admissions, and length of hospital stay. For sensitivity analyses, we restricted the overall cohort to include only hip fracture surgeries performed within 2 days from admission.

RESULTS:
Overall, 34,679 (52.1%) of 66,620 surgical patients underwent preoperative echocardiography screening. The screened patients (mean [SD] age, 84.3 years [7.7 years]; 79.0% female) were propensity score matched to 31,941 nonscreened patients (mean [SD] age, 82.1 years [8.7 years]; 78.2% female). The overall in-hospital mortality, before propensity matching, was 1.8% (1227 patients). Propensity score matching created a matched cohort of 25,205 pairs of patients. There were no in-hospital mortality differences between the 2 groups (screened versus nonscreened: 417 [1.65%] vs 439 [1.74%]; odds ratio, 0.95; 95% confidence interval, 0.83–1.09; P = .45). Preoperative echocardiography was not associated with reduced postoperative complications and intensive care unit admissions. In sensitivity analysis, we identified 25,637 patients from the overall cohort (38.5%) with hip fracture surgeries performed within 2 days of admission. There were no in-hospital mortality differences between the 2 groups (screened versus nonscreened: 1.67% vs 1.80%; odds ratio, 0.93; 95% confidence interval, 0.72–1.18; P = .53). Findings were also consistent with other sensitivity analyses and subgroup analyses.

CONCLUSIONS:
This large, retrospective, nationwide cohort study demonstrated that preoperative echocardiography was not associated with reduced in-hospital mortality or postoperative complications.
National Partnership for Maternal Safety Recommended Maternal Early Warning Criteria Are Associated With Maternal Morbidity
Authors: Arnolds David E. , Smith Aaron , Banayan Jennifer M. , Holt Roxane , Scavone Barbara M. 
Published: October 2018

BACKGROUND:
Many cases of maternal mortality and morbidity are preventable. A delayed response to clinical warning signs contributes to preventability. Therefore, the National Partnership for Maternal Safety devised maternal early warning criteria (MEWC), composed of abnormal vital signs that trigger bedside evaluation by a provider with the capacity to escalate care. The relationship of the MEWC to maternal morbidity has not been studied. We evaluated the correlation between the MEWC and maternal morbidity.

METHODS:
We retrospectively reviewed the first 400 deliveries at the University of Chicago in 2016. We analyzed the electronic medical record to determine whether vital signs triggered the MEWC during the admission to labor and delivery and whether patients experienced morbidity during their delivery hospitalization. The association between MEWC and morbidity was tested using χ2 analysis. We calculated the sensitivity, specificity, and positive and negative predictive values of the MEWC.

RESULTS:
Two hundred eighty-one (70%) of 400 patients triggered the MEWC at least once, and 198 (50%) of 400 patients had multiple or recurrent triggers. Ninety-nine (25%) of 400 patients experienced morbidity. The most common causes of morbidity were hemorrhage, suspected infection, and preeclampsia with severe features. The relative risk of maternal morbidity with at least a single trigger was 13.55 (95% confidence interval [CI], 4.38–41.91) and with recurrent or multiple triggers was 5.29 (95% CI, 3.22–8.71). The sensitivity of the MEWC in predicting morbidity was 0.97 (95% CI, 0.92–0.99) and the specificity was 0.39 (95% CI, 0.33–0.44) when patients with at least a single trigger were included. When including only patients with multiple or recurrent triggers, the sensitivity was 0.84 (95% CI, 0.75–0.90) and the specificity was 0.62 (95% CI, 0.56–0.67). The positive predictive value of the MEWC in our population was 0.34 (95% CI, 0.29–0.40), and the negative predictive value was 0.97 (95% CI, 0.93–0.99). When considering only patients with multiple or recurrent triggers, the positive predictive value was 0.42 (95% CI, 0.38–0.46) and the negative predictive value was 0.92 (95% CI, 0.88–0.95).

CONCLUSIONS:
The MEWC are associated with maternal morbidity. As a screening tool, they appropriately prioritize sensitivity and have an excellent negative predictive value. The criteria demonstrate low specificity, which is slightly improved by considering only patients with recurrent or multiple triggers. Additional efforts to improve the specificity of MEWC, with a focus on identifying sustained or recurrent patterns of abnormal vital signs, may be necessary before their widespread implementation.
WDR5 regulates left-right patterning via chromatin-dependent and -independent functions
Authors: Kulkarni Saurabh S. , Khokha Mustafa K. 
Published: October 2018

ABSTRACT
Congenital heart disease (CHD) is a major cause of infant mortality and morbidity, yet the genetic causes and mechanisms remain opaque. In a patient with CHD and heterotaxy, a disorder of left-right (LR) patterning, a de novo mutation was identified in the chromatin modifier gene WDR5. WDR5 acts as a scaffolding protein in the H3K4 methyltransferase complex, but a role in LR patterning is unknown. Here, we show that Wdr5 depletion leads to LR patterning defects in Xenopus via its role in ciliogenesis. Unexpectedly, we find a dual role for WDR5 in LR patterning. First, WDR5 is expressed in the nuclei of monociliated cells of the LR organizer (LRO) and regulates foxj1 expression. LR defects in wdr5 morphants can be partially rescued with the addition of foxj1. Second, WDR5 localizes to the bases of cilia. Using a mutant form of WDR5, we demonstrate that WDR5 also has an H3K4-independent role in LR patterning. Guided by the patient phenotype, we identify multiple roles for WDR5 in LR patterning, providing plausible mechanisms for its role in ciliopathies like heterotaxy and CHD.
Associations of Resistance Exercise with Cardiovascular Disease Morbidity and Mortality
Authors: LIU YANGHUI , LEE DUCK-CHUL , LI YEHUA , ZHU WEICHENG , ZHANG RIQUAN , SUI XUEMEI , LAVIE CARL J. , BLAIR STEVEN N. 
Published: October 2018

ABSTRACT

Purpose
Resistance exercise (RE) can improve many cardiovascular disease (CVD) risk factors, but specific data on the effects on CVD events and mortality are lacking. We investigated the associations of RE with CVD and all-cause mortality and further examined the mediation effect of body mass index (BMI) between RE and CVD outcomes.

Methods
We included 12,591 participants (mean age, 47 yr) who received at least two clinical examinations 1987–2006. RE was assessed by a self-reported medical history questionnaire.

Results
During a mean follow-up of 5.4 and 10.5 yr, 205 total CVD events (morbidity and mortality combined) and 276 all-cause deaths occurred, respectively. Compared with no RE, weekly RE frequencies of one, two, three times or total amount of 1–59 min were associated with approximately 40%–70% decreased risk of total CVD events, independent of aerobic exercise (AE) (all P values <0.05). However, there was no significant risk reduction for higher weekly RE of more than four times or ≥60 min. Similar results were observed for CVD morbidity and all-cause mortality. In the stratified analyses by AE, weekly RE of one time or 1–59 min was associated with lower risks of total CVD events and CVD morbidity regardless of meeting the AE guidelines. Our mediation analysis showed that RE was associated with the risk of total CVD events in two ways: RE had a direct U-shaped association with CVD risk (P value for quadratic trend <0.001) and RE indirectly lowered CVD risk by decreasing BMI.

Conclusion
Even one time or less than 1 h·wk−1 of RE, independent of AE, is associated with reduced risks of CVD and all-cause mortality. BMI mediates the association of RE with total CVD events.
The Role of Aerobic Exercise in Reducing Persistent Sport-related Concussion Symptoms
Authors: HOWELL DAVID R. , TAYLOR J. ANDREW , TAN CAN OZAN , ORR RHONDA , MEEHAN WILLIAM P. 
Published: October 2018

ABSTRACTAerobic exercise has received increasing attention in the scientific literature as a component of management for individuals who sustain a concussion. Because exercise training has been reported to reduce symptoms and improve function for those experiencing persistent postconcussion symptoms, it represents a potentially useful and clinically pragmatic rehabilitation technique. However, the specific exercise parameters that best facilitate recovery from concussion remain poorly defined and unclear. This review will provide a summary of the current understanding of the role of subsymptom exercise to improve outcomes after a concussion and will describe the exercise parameters that appear to be important. The latter will take into account the three pillars of exercise dose—frequency, duration, and intensity—to examine what is currently known. In addition, we identify important gaps in our knowledge of exercise as a treatment for those who develop persistent symptoms of concussion.
THE LIFE OF MUSLIM INDONESIAN STUDENTS IN GERMANY: CHALLENGES AND OPPORTUNITIES
Authors: Majid Gilang Maulana 
Published: October 2018

Immigration of people attached to a certain religion in a country where most of the population do not embrace the same religion has always been an interesting topic to explore, especially when it is regarding the discourse of student mobility in higher education world. A lot of factors must be taken into account before one makes a decision on which country to continue the study. As Muslims adhere to certain religious values, any factor that supports one’s piousity would be ideally weighed. This study explores the life of Muslim Indonesian students studying in Germany. Departing from the study motivation, the concept of push and pull factor is then enriched with religious perspectives. The research findings show that even though there are challenges that these students face as a Muslim, there is still an interesting opportunity that they have experienced when residing in Germany and later deem most significant in relation to their Islamicity. Realizing the importance of this kind of discourse for Indonesian immigrants, be it student or non-student, a suggestion of further research under the same topic is emphasized. Keywords: Germany, Hajj, higher education,Muslim Indonesian student, push-pull factor AbstrakImigrasi orang-orang yang melekat pada agama tertentu di negara yang mana sebagian besar penduduknya tidak memeluk agama yang sama selalu menjadi topik yang menarik untuk dieksplor, terutama ketika menyangkut wacana mobilitas siswa di dunia pendidikan tinggi. Banyak faktor harus diperhitungkan sebelum seseorang membuat keputusan ke negara mana untuk melanjutkan studi. Sebagai umat Islam yang mematuhi nilai-nilai agamanya, setiap faktor yang mendukung kesalehan seseorang akan dipertimbangkan. Studi ini mengeksplorasi kehidupan pelajar Indonesia Muslim yang belajar di Jerman. Studi ini berangkat dari motivasi belajar, konsep push dan pull factor yang kemudian diperkaya dengan perspektif agama. Temuan penelitian menunjukkan bahwa meskipun ada tantangan yang dihadapi para siswa ini sebagai seorang Muslim, namun masih ada peluang menarik yang mereka alami ketika tinggal di Jerman yang kemudian dianggap sangat penting dalam kaitannya dengan keislaman mereka. Menyadari pentingnya wacana semacam ini bagi para imigran Indonesia, baik itu mahasiswa maupun non-pelajar, maka perlu penelitian lebih lanjut dengan topik yang sama.Kata kunci: Mahasiswa Muslim Indonesia, Jerman, push-pull factor,pendidikan tinggi, Haji
WORK INTEGRATION SOCIAL ENTREPRENEURSHIP IN EAST-CENTRAL EUROPE THROUGH STRUCTURAL AND SEMIOTIC TRANSFORMATIONS
Authors: GOLOB Tea , MAKAROVIČ Matej 
Published: October 2018

The central question addressed is how the structural and semiotic contexts, seen from the perspective of the cultural political economy, of the selected post-communist societies of East-Central Europe (Croatia, Czech Republic, Slovenia, and Poland) have affected the historical development and contemporary situation of social entrepreneurship focused on the integration of the disadvantaged social groups in the labour market (work integration social enterprises (WISEs)). Based on secondary data, surveys, semi-structured interviews and focus groups with the stakeholders from the transnational project INNO WISEs, we identify both the communist and post-communist transformations as mostly unfavourable for WISE, while the crucial factor contributing to their selection as a viable option after 2004 has been the external impact of the European Union-related structures and discourses.
On non-Kähler degrees of complex manifolds
Authors: Angella Daniele , Tomassini Adriano , Verbitsky Misha 
Published: October 2018

Abstract
We study cohomological properties of complex manifolds. In particular, under suitable metric conditions, we extend to higher dimensions a result by A. Teleman, which provides an upper bound for the Bott– Chern cohomology in terms of Betti numbers for compact complex surfaces according to the dichotomy b
1 even or odd.
Fall and Winter Movements of Newfoundland Graycheeked Thrushes (Catharus Minimus Minimus)
Authors: Whitaker Darroch M. , Warkentin Ian G. , Hobson Keith A. , Thomas Peter , Boardman Rinchen 
Published: October 2018

Abstract
The Newfoundland subspecies of Gray-cheeked Thrush (Catharus minimus minimus) has declined since the 1980s and degradation of winter habitat has been suggested as a contributing stressor. However, the winter range of this subspecies is not well understood, so we fitted 29 males with archival GPS tags during summer 2016. Four tagged thrushes were recaptured in summer 2017 and, though all tags had missing locations and broken antennae, the data retrieved showed that one thrush wintered in the Sierra Nevada de Santa Marta (SNSM) in northern Colombia, one in the nearby Sierra de Perija in Venezuela, and a third may have settled in the same region. One tag provided locations until April 21 and that thrush was consistently detected within a ~1 ha area through the winter. Locations obtained during fall migration indicated that thrushes travelled to South America via Central America and possibly by directly crossing the Caribbean. Contemporary research indicates that the SNSM is an important migratory stopover for Northern Gray-cheeked Thrushes (C. m. aliciae) but a historical report coupled with our observations suggest winter use of the SNSM and adjacent areas in northern South America by C. m. minimus, though numbers may be lower than during the 1900s.
Large scale hydrodynamic modes of oscillations in gaseous disks of flat galaxies with a kink on rotation curves
Authors: Torgashin Yury , Omurkanov Turgunbek 
Published: October 2018

Abstract
The properties of unstable large-scale hydrodynamic (HD) modes of oscillations in the gaseous disk of a flat galaxy with a rotation curve having a velocity jump in the inner region of the disk are numerically investigated. It is shown that some of these modes can form a regular pseudo-ring, and others can generate a spiral structure in a model galactic disk, with the rotation curve that can approximate the observed rotation curves in nearby massive spiral galaxies (such as M31, M81). The characteristic time of formation of the regular structure turns out to be . (1 − 2) GY, the corotation is located in the region of the velocity jump (on the radius∼ 2 − 4 kpc). The properties of the generated densitywaves are determined by the parameters of the velocity jumpon the rotation curve (relative amplitude and steepness of the velocity profile decrease), as well as the temperature (velocity dispersion) of the gas in the disk. For the first time, it was investigated how the global HD modes and the spiral structures formed by them will change in the case of the presence of a jump in the profile of the equilibrium surface density. This model profile was set in the form of a slightly smeared falling density step. Main results were obtained for two-arm m = 2 azimuthal harmonic.
Brush seal with thermo-regulating bimetal elements
Authors: Stanclik Michał 
Published: October 2018

Abstract
This paper presents a new brush seal construction idea. It was shown that it is possible to use bimetallic elements for the construction of the brush seal, which have a thermoregulatory function by relieving a contact area between bristles and a shaft surface reducing frictional heat flux. This should improve the durability of the seal by diminishing the heat load and significantly decreases the temperature of the seal during the startup/ shutdown. This article shows a simplified construction of the concept brush seal as well as numerical and experimental results.
Beneficial effects of auricular acupressure on preventing constipation in breast cancer patients undergoing chemotherapy: evidence from systematic review and meta-analysis
Authors: Zheng Su-Hua , Yan Min , Field Tiffany , Xu Xiao 
Published: October 2018

Abstract

Objective
To evaluate the available evidence from randomized controlled trials (RCTs) of auricular acupressure (AA) therapy for preventing constipation in breast cancer patients undergoing chemotherapy.

Methods
The following databases were searched from their inception until August 2017: Ovid Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and Allied and Alternative Medieine (AMED). We also searched four Chinese databases: Chinese BioMedical Database (CBM), China National Knowledge Infrastructure (CNKI), WANFANG Data, and Chinese VIP Database. Only the RCTs related to the effects of AA therapy on preventing constipation in breast cancer patients undergoing chemotherapy were included in this study. Quantitative syntheses of data from RCTs were conducted using RevMan 5.3 software. Study selection, data extraction, and validation were performed independently by two authors. Cochrane criteria for risk of bias were used to assess the methodological quality of the trials.

Results
Four RCTs met the inclusion criteria, and most were of low methodological quality. Study participants in the AA plus routine care group showed significantly greater improvements in the response rate (risk ratio [RR] = 1.27, 95% confidence interval [CI] [1.14,1.42], P < 0.01) with low heterogeneity χ2 = 2.31, P = 0.31, l2 = 14%). In addition, when compared with routine care alone, one RCT suggested favorable statistically significant effects of AA plus routine care on Constipation Assessment Scale (CAS; mean difference [MD] = -5.07,95% CI [-6.86, -3.28], P < 0.01). Furthermore, when compared with routine care alone, one RCT suggested positive statistically significant effects of AA plus routine care on Patient Assessment of Constipation-Quality of Life (PAC-QOL; MD = -1.26,95% CI [-1.59, -0.93], P < 0.01).

Conclusions
Overall, as a potential safety therapy, only weak evidence can support the hypothesis that AA can effectively prevent constipation in breast cancer patients undergoing chemotherapy.
Cyclicity in homotopy algebras and rational homotopy theory
Authors: Kajiura Hiroshige 
Published: October 2018

Abstract
Kadeishvili proposes a minimal

C
∞

{C_{\infty}}

-algebra as a rational homotopy model of a space. We discuss a cyclic version of this Kadeishvili

C
∞

{C_{\infty}}

-model and apply it to classifying rational Poincaré duality spaces.
We classify 1-connected minimal cyclic

C
∞

{C_{\infty}}

-algebras whose cohomology algebras are those of

(

S
p

×

S

p
+

2
⁢
q

-
1

)

⁢
♯
⁢

(

S
q

×

S

2
⁢
p

+
q

-
1

)

{(S^{p}\times S^{p+2q-1})\sharp(S^{q}\times S^{2p+q-1})}

, where

2
≤
p
≤
q

{2\leq p\leq q}

.
We also include a proof of the decomposition theorem for cyclic

A
∞

{A_{\infty}}

and

C
∞

{C_{\infty}}

-algebras.
Solution of the Ulam stability problem for Euler–Lagrange k-quintic mappings
Authors: Mohiuddine Syed Abdul , Rassias John Michael , Alotaibi Abdullah 
Published: October 2018

Abstract
The “oldest quartic” functional equation

f
⁢

(

x
+

2
⁢
y

)

+

f
⁢

(

x
-

2
⁢
y

)

=

4
⁢

[

f
⁢

(

x
+
y

)

+

f
⁢

(

x
-
y

)

]

-

6
⁢
f
⁢

(
x
)

+

24
⁢
f
⁢

(
y
)

f(x+2y)+f(x-2y)=4[f(x+y)+f(x-y)]-6f(x)+24f(y)

was introduced and solved by the second author of this paper (see J. M. Rassias,
Solution of the Ulam stability problem for quartic mappings,
Glas. Mat. Ser. III 34(54) 1999, 2, 243–252).
Similarly, an interesting “quintic” functional equation was introduced and investigated by I. G. Cho, D. Kang and H. Koh,
Stability problems of quintic mappings in quasi-β-normed spaces,
J. Inequal. Appl. 2010 2010, Article ID 368981,
in the following form:

2
⁢
f
⁢

(

2
⁢
x

+
y

)

+

2
⁢
f
⁢

(

2
⁢
x

-
y

)

+

f
⁢

(

x
+

2
⁢
y

)

+

f
⁢

(

x
-

2
⁢
y

)

=

20
⁢

[

f
⁢

(

x
+
y

)

+

f
⁢

(

x
-
y

)

]

+

90
⁢
f
⁢

(
x
)

.

2f(2x+y)+2f(2x-y)+f(x+2y)+f(x-2y)=20[f(x+y)+f(x-y)]+90f(x).

In this paper, we generalize this “Cho–Kang–Koh equation” by introducing pertinent Euler–Lagrange k-quintic functional equations, and investigate the “Ulam stability” of these new k-quintic functional mappings.