bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins
Authors: Keuter Lucas , Fortmann Marco , Behrens Matthias , Humpf Hans-Ulrich 
Published: December 2024

Abstract
Toxic fungal secondary metabolites, referred to as mycotoxins, emerge in moldy food and feed and constitute a potent but often underestimated health threat for humans and animals. They are structurally diverse and can cause diseases after dietary intake even in low concentrations. To elucidate cellular responses and identify cellular targets of mycotoxins, a bottom-up proteomics approach was used. We investigated the effects of the mycotoxins aflatoxin B1, ochratoxin A, citrinin, deoxynivalenol, nivalenol and penitrem A on the human hepatoblastoma cell line HepG2 and of ochratoxin A and citrinin on the human kidney epithelial cell line IHKE. Incubations were carried out at sub-cytotoxic concentrations to monitor molecular effects before acute cell death mechanisms predominate. Through these experiments, we were able to detect specific cellular responses that point towards the mycotoxins’ mode of action. Besides very well-described mechanisms like the ribotoxicity of the trichothecenes, we observed not yet described effects on different cellular mechanisms. For instance, trichothecenes lowered the apolipoprotein abundance and aflatoxin B1 affected proteins related to inflammation, ribogenesis and mitosis. Ochratoxin A and citrinin upregulated the minichromosomal maintenance complex and nucleotide synthesis in HepG2 and downregulated histones in IHKE. Penitrem A reduced enzyme levels of the sterol biosynthesis. These results will aid in the elucidation of the toxicodynamic properties of this highly relevant class of toxins.
Immediate postoperative course in the pediatric intensive care unit following epilepsy surgery
Authors: Ayalon Itay , Friedman Shirley , Meidan Barak , Sadot Efraim , Constantini Shlomi , Uliel-Sibony Shimrit , Roth Jonathan 
Published: December 2024

Abstract
Purpose
To describe the immediate postoperative PICU course and short-term outcomes of children undergoing various epilepsy surgeries.

Methods
Single-center, retrospective observational study. All patients younger than 20 years of age who had been admitted to the PICU between 2018 and 2022 following epilepsy surgery were eligible for study entry.

Results
Fifty-two children (median age 7.9 years) underwent epilepsy surgery during the study period (25 focal lesionectomies and lobectomies [FL], 10 corpus callosotomy [CC], and 17 hemispheric surgeries [HS]). The average number of preoperative antiseizure medications (ASM) was 3, and the average number of failed ASM was 6. Cortical dysplasia was the most frequent etiology (25%). Preoperative cognitive delay and motor deficits were reported in 38 (74%) and 26 (50%) patients, respectively. The median length of stay in the PICU was 1 day (5 for the HS group). No seizures occurred among 44 (85%) children during the first postoperative day nor during the entire hospital stay in 40 (77%) patients (20/25 [82%] in the FL group, 4/10 [40%] in the CC group, and 14/17 [82%] in the HS group). There were no status epilepticus events during the PICU stay. None of patients required hemodynamic support, and only 3(6%) needed respiratory support. Twenty-six patients (50%) had electrolyte abnormalities. Pain was mostly perceived as mild. Fever was present in 28 (54%) patients, most notably in the HS group (94%).

Conclusion
Epilepsy surgery in children is associated with very limited immediate postoperative morbidity and low seizure burden, especially in the FL and HS groups.
Health problems in children with profound intellectual and multiple disabilities: a scoping review
Authors: Zandbelt Lian M. , Gijssel Esther J. Bakker-van , Coppens Catelijne H. , Draaisma Jos M. T. , Geelen Joyce M. 
Published: December 2024

Abstract
This study aims to investigate and categorize health problems in children with profound intellectual and multiple disabilities (PIMD). We conducted a scoping review in five electronic databases (PubMed, Embase, Medline, PsychInfo, and Web of Science), including peer-reviewed studies that describe health problems in children with PIMD. Articles on PIMD were included when mentioning children with severe or profound intellectual disability (IQ/DQ < 35 or developmental age < 24 months) AND severe/profound motor impairment (GMFCS IV/V, non-ambulatory/not walking without support or gross motor function measure (GMFM-66) score < 40). Health problems were divided into 11 different categories based on literature and the experiences of the authors. Both health problems reported by caregivers and diagnosed by health professionals were included. A data extraction tool was developed using the JBI checklist recommendations. The review included 22 studies, with a total of 894 patients across all the articles. The most reported health problems in children with PIMD were epilepsy, respiratory infections, feeding difficulties, GERD, scoliosis, and visual impairment. There was no uniformity in the definition and terminology of PIMD. Conclusion: The studies in this review covered a wide range of health problems, with only a few focusing on the entire range. Given the lack of knowledge about children with PIMD, further research is required on the presence of health problems, the age of onset, and appropriate treatments. Awareness, early detection, and treatment of the health problems could optimize the medical care and quality of life of children with PIMD.

What is Known:
• Children with profound intellectual and multiple disabilities (PIMD) have severe intellectual and motor disabilities and various comorbidities.
• Children often visit the hospital and provided care is complex and fragmented.

What is New:
• Children with PIMD develop a wide range of health problems; most reported are epilepsy, respiratory infections, and feeding difficulties.
• Little is known about treatment of health problems in children with PIMD.
Holocene onshore/offshore tephra correlation of Mt. Etna, Sicily
Authors: Lippert Antina , Schindlbeck-Belo Julie Christin , Hansteen Thor H. , Del Carlo Paola , Heinrich Mirja , Behncke Boris , Bonforte Alessandro , Urlaub Morelia , Kolling Henriette , Barrett Rachel , Gross Felix 
Published: December 2024

Abstract
The volcanic history of Mt. Etna is mainly known from studies of subaerial deposits and stratigraphy. However, little is known about the offshore deposits, which can provide a more detailed insight into geological and sedimentological processes affecting the flanks of Mt. Etna. During RV Meteor Cruise M178, eight gravity cores were taken offshore across the continental margin east of the volcanic edifice to re-evaluate the volcanic history of pre-historic eruptions and mass wasting events in the area. In total, we investigated 87 marine tephra layers in order to build a marine tephrostratigraphic framework. Based on major element compositions of glass shards, sediment componentry, and petrographic characteristics, 27 layers were identified as primary pyroclastic flow and fall deposits, i.e., directly related to an explosive volcanic eruption. However, most of the remaining tephra layers are interpreted to represent deposits of secondary density currents and are not necessarily related to a volcanic eruption. The marine dataset is complemented by twelve onshore samples taken from major explosive eruptions. Applying geochemical fingerprinting of volcanic glass shard compositions, we correlated eleven marine tephra deposits to seven well-known Mt. Etna eruptions (FV, FF, FG, FL, FS, TV, and M1 eruptions) within the last 12 kyr, which provide valuable time markers in the marine sediment record. Furthermore, we correlated ten marine tephra layers between the marine cores (four individual eruptions) and identified another six primary layers in single cores. In total, we discovered 17 widespread volcanic events in the marine record, including four previously unknown eruptions between 10 and 7.7 ka, which indicate that Mt. Etna was more active than previously thought during this time period.
Minimisers of supremal functionals and mass-minimising 1-currents
Authors: Katzourakis Nikos , Moser Roger 
Published: December 2024

Abstract
We study vector-valued functions that minimise the

$$L^\infty $$

L
∞

-norm of their derivatives for prescribed boundary data. We construct a vector-valued, mass minimising 1-current (i.e., a generalised geodesic) in the domain such that all solutions of the problem coincide on its support. Furthermore, this current can be interpreted as a streamline of the solutions. The construction relies on a p-harmonic approximation. In the case of scalar-valued functions, it is closely related to a construction of Evans and Yu (Commun Partial Differ Equ 30:1401–1428, 2005). We therefore obtain an extension of their theory.
Pharmakotherapie und Kinderwunsch
Authors: Staack Anke Maren , Steinhoff Bernhard J. 
Published: December 2024

Zusammenfassung
Pharmakotherapie und Kinderwunsch sind ein anspruchsvolles Thema, das hauptsächlich, aber nicht ausschließlich Frauen im gebärfähigen Alter betrifft, die ein Drittel aller Patientinnen mit Epilepsie ausmachen. Im folgenden Beitrag werden aktuelle Studiendaten dargestellt, daraus resultierende Empfehlungen bei Menschen mit Epilepsie und Kinderwunsch kritisch beleuchtet und eigene Erfahrungen in der Behandlung mit Frauen im gebärfähigen Alter bzw. schwangeren Frauen mit Epilepsie diskutiert. In der Zusammenschau können die Erkenntnisse zum Thema erhöhtes Fehlbildungsrisiko weitgehend bestätigt werden, wenige neue Daten werden unsere Vorgehensweise in gewissen Punkten ändern. Vorausschauende Auswahl der anfallssuppressiven Medikamente bei Frauen im gebärfähigen Alter, proaktive Aufklärung und der pragmatische Umgang bei ungeplanter Schwangerschaft sollen dazu beitragen, das Teratogenitätsrisiko zu senken bzw. Komplikationen für Mutter und Kind in der Schwangerschaft zu reduzieren.
Path-based DEA models in multiplier form and returns-to-scale analysis
Authors: Trnovská Mária , Halická Margaréta , Hrdina Jakub 
Published: December 2024

AbstractData envelopment analysis (DEA) models appear in envelopment and multiplier forms, which are in a primal-dual relationship. In this paper, we derive the general multiplier form of path-based models, encompassing radial, directional distance function, and hyperbolic distance function models as special cases. We investigate the economic interpretation of the multiplier models and uncover the link between shadow profit inefficiency and technical inefficiency provided by path-based models. Using the optimality conditions for the primal-dual pair, we precisely describe the two-way relationship between the optimal solutions of the multiplier model and the supporting hyperplanes of the technology set at the projection. This relationship serves as a mathematical justification for extending one of the early approaches to measuring returns-to-scale (RTS) onto the entire class of path-based models. Moreover, we demonstrate the eligibility of this method by revealing the fact that the set of all strongly efficient benchmarks for the assessed unit in path-based models does not need to belong to a single strongly efficient face of technology set. This finding changes the view on traditional approaches to RTS measurement that rely on supporting hyperplanes encompassing a single strongly efficient face of the technology set. In this new perspective, we propose two methods for RTS measurement. The first is based on the hyperplanes at the projection, and the second method adapts the minimum face method to be suitable for path-based models. Both methods are fully justified and brought to an algorithmic form.
From Complementarity to Mutual Recognition and Thirdness in Child–Parent Psychotherapy
Authors: Saar-Heiman Yuval 
Published: December 2024

AbstractThis article explores the integration of Jessica Benjamin’s concepts of ‘mutual recognition’ and ‘the third’ into child-parent psychotherapy (CPP), a relationship-based trauma-informed dyadic intervention model rooted in attachment theory. Despite the significance of caregiver-child relationships in trauma response, Benjamin’s work remains underutilized in the CPP literature. This article uses a case illustration to demonstrate how incorporating Benjamin’s concepts enriches CPP interventions that address the relational impact of trauma on young children. Three strategies are outlined to cultivate thirdness within CPP, drawing from clinical material: exploring trauma and complementarity, distinguishing play from reality, and working with the clinician’s subjectivity. The article illustrates how the utilization of Benjamin’s concepts can complement CPP and how emphasizing the intersubjective dynamic between parent and child, enhancing parental subjectivity, and prioritizing the repair of recognition breakdowns can support clinicians in advancing the therapeutic goals of CPP.
Introduction to the Special Issue: ‘The public good of higher education: A comparative study’
Authors: Brewis Elisa , Marginson Simon 
Published: December 2024

Abstract
The Special Issue provides the first consolidated outcomes from a large cross-country research project, conducted by the UK-based Centre for Global Higher Education, on the contributions of higher education to public good outcomes. The public good outcomes of higher education are outcomes other than private pecuniary benefits like individual earnings, employment or social status: (a) shared collective social goods, such as the contributions of higher education to social tolerance, or democratic governance and (b) non-pecuniary individual goods such as the lifetime contribution of higher education to the subjectification (self-formation) of students and to their socialisation as citizens in relational settings. This non-pecuniary domain is underplayed or hidden in those economic policies in the Anglosphere that imagine social life in exclusively transactional terms and model students as consumers, universities as businesses and higher education systems as competitive markets, suggesting the need to move beyond the Anglosphere. The research studies reported here compare approaches to public good outcomes (or their nearest lexical equivalents) in Chile, China, Finland, France, Japan and Poland, as well as Canada and England. This introduction explains the project and presents the country studies, also acknowledging the limitations of the research. It concludes with a summary of the research outcomes across the eight countries, including similarities and differences, and a generic transpositional analysis that integrates the separate findings into a single overall picture of the contribution of higher education to the public good in the eight countries.
Undocumented immigrants and the growth of Hispanic entrepreneurship
Authors: Wang Chunbei , Wang Le 
Published: December 2024

AbstractOver the last two decades, there has been a significant surge in the self-employment rate among Hispanics, especially among Hispanic immigrants. However, the reasons behind this increase remain underexplored. This paper addresses this gap by examining the role of undocumented immigrants, a substantial part of the Hispanic immigrant population, by discerning immigrants’ legal status in the Current Population Survey–Annual Social and Economic data (1994–2018). The findings reveal that the nearly doubled self-employment rate among Hispanic immigrants is primarily driven by undocumented individuals, especially those of Mexican origin. A key factor is the post-9/11 tightening of immigration enforcement, which worsened job prospects for undocumented immigrants, pushing many into self-employment. This event triggered a distinct pattern in Hispanic self-employment, setting it apart from other demographic groups. Other factors, such as business cycles, state-level immigration policies, the gig economy, and the growth of the Hispanic community, also contribute but play a lesser role.
Narrative Railroading
Authors: Osler Lucy 
Published: December 2024

AbstractThe narratives we have about ourselves are important for our sense of who we are. However, our narratives are influenced, even manipulated, by the people and environments we interact with, impacting our self-understanding. This can lead to narratives that are limited, even harmful. In this paper, I explore how our narrative agency is constrained, to greater and lesser degrees, through a process I call ‘narrative railroading’. Bringing together work on narratives and 4E cognition, I specifically explore how using features of our socio-material environments to support and construct our narratives does not simply offer up possibilities for creating more reliable and accurate self-narratives (Heersmink 2020) but can lead to increasingly tight narrative railroading. To illustrate this idea, I analyse how digital technologies do not neutrally distribute our narratives but dynamically shape and mould narrative agency in ways that can restrict our self-understanding, with potentially harmful consequences. As such, I argue that we need to recognise that digital devices not only support narratives but work as powerful narrative devices, shaping and propagating the kinds of narratives that we self-ascribe and act in accordance with.
Dementia prediction with multimodal clinical and imaging data
Authors: Kubi Nana Nyarko Brenya Appiah , Nazir Sajid 
Published: December 2024

Abstract
Dementia affects millions of people worldwide, and poses significant challenges due to its irreversible nature and a lack of effective treatment options. Dementia has a considerable influence on people and society and puts a heavy burden on the healthcare systems. This underscores an urgent need for proactive measures to address this public health concern through early detection and intervention. This paper investigates the use of machine learning for an early detection of dementia and its progression utilizing a public dataset. Various traditional machine learning algorithms, were used on the demographic data, with the Gaussian Naïve Bayes achieving the highest accuracy of 91.30%. Four deep learning models, ResNet50, DenseNet121, VGG16, and Inceptionv3 were used on image data, with the DenseNet121 model achieving the highest accuracy of 90%. We also used SHapley Additive exPlanations (SHAP) framework for dementia progression which revealed that Normalised Whole Brain Volume (nWBV) exhibited higher variability in their impact across models. This study demonstrates the potential of machine learning approaches for early dementia detection and prognosis, which can have significant effect in patient care strategies.
Quality Improvement in Deep Brain Stimulation for Movement Disorders: Pandemic Impact on Specialized Elective Surgery
Authors: Yen Kevin , Torabi Pouria , Miyasaki Janis M. , Sankar Tejas , Ba Fang 
Published: December 2024

ABSTRACT

Background:
Deep brain stimulation (DBS) is an important treatment for Parkinson’s disease, tremor and dystonia in appropriately selected patients. The Canada Health Act emphasizes equity and “reasonable access to medically necessary hospital and physician services.” How to define “reasonable access” has not been well studied. We aimed to assess access to DBS implantation surgery and to determine the time required from initial assessment through to surgery and which step(s) delay the implantation.

Methods:
DBS implants from 2016 to 2023 at the University of Alberta were analyzed. The neurologists’ decision to proceed with DBS marks the start of the workup. The time required to see a neurosurgeon, psychiatrist, neuropsychologist and healthcare allies and to receive DBS surgery was assessed. The impact of COVID-19 was studied.

Results:
The total time from starting the workup to DBS surgery was 387.76 ± 125.19 days prior to COVID-19, and marked delay occurred during and post-COVID-19 (840.15 ± 165.41 days and 839.78 ± 300.66 days, respectively). Most workups were done within 6 months pre-COVID-19, although a big range existed due to variable factors. The longest delay to surgery was from consent to DBS implantation, owing to a lack of operative time. There has not been a recovery post-pandemic.

Conclusions:
Time to DBS implantation surgery from initial decision is lengthy and more than doubled over the course of the COVID-19 pandemic. The biggest delay was in the time from consent to implantation surgery, which has not improved despite the pandemic having ended.
Review of the application of infrared spectroscopy in studies of acid-treated clay minerals
Authors: Madejová Jana , Pálková Helena 
Published: December 2024

Abstract
Acid activation of clay minerals is one of the most effective methods for production of materials with increased acidity and porosity. In this review, the benefits of infrared (IR) spectroscopy in studies of acid-treated clay minerals are demonstrated. Protons penetrating into the clay mineral layers evoke structural modifications that can be followed readily by changes in the characteristic absorption bands attributed to the vibrations of the OH and Si–O groups. In the first part of the review the effect of the clay mineral type, composition, layer charge, non-swelling layers, and organo-modification on the dissolution rate is reported. The identification of the acid sites via pyridine adsorption also included. The purpose was to gather the IR results published in previous studies in a single summary paper. In the second part select recent studies reporting the utilization of IR spectroscopy for the characterization of acid-activated clay minerals, mainly applied as catalysts or adsorbents, are discussed. IR spectroscopy as a simple and non-destructive technique deserves attention also today.
A qualitative study to explore and identify reasons for dairy consumption and non-consumption among young adults (18–30 years old) in the UK and France
Authors: Franzon Caterina , Dougkas Anestis , Memery Juliet , Prigent Justine , Appleton Katherine M. 
Published: December 2024

Abstract
The aim of this study was to explore and identify why young adults aged between 18 and 30 years in the UK and France do or do not consume dairy products. Several studies have associated dairy products with a healthy diet, and the production of soft dairy, i.e. milk, yoghurt, and soft cheese, as more environmentally friendly than some other animal-based products. Yet recent reports highlight that dairy intake is lower than recommended for health, especially among young adults. Using a qualitative methodology, forty-five participants aged 18–30 years (UK: n = 22; France: n = 23) were asked about their reasons for (non)consumption of a wide range of dairy products. Audio-recorded focus groups and individual interviews were conducted in English in the UK and in French in France, transcribed and coded. A thematic analysis found four themes and sixteen sub-themes (theme product-related: sub-themes sensory, non-sensory, composition; theme individual-related: sub-themes mode of consumption, preferences, personal reasons, knowledge, attitudes and concerns, needs or cravings; theme cultural aspects: sub-themes product categorization, social norms, use; theme market offering: sub-themes alternative, packaging, value for money, availability) to influence participants’ dairy (non)consumption in both countries. A seventeenth sub-theme (theme cultural aspects: sub-theme structure of the meal) was found to influence dairy consumption only in France. Further studies are needed to investigate these themes within larger samples, but these findings contribute to understanding dairy (non)consumption in young adults in the UK and France and may aid the development of strategies to improve young adults’ diets.