bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clustering of malignant pleural mesothelioma in asbestos factories: a subgroup analysis in a 29-year follow-up study to identify high-risk industries in Taiwan
Authors: Lee Lukas Jyuhn-Hsiarn , Lin Cheng-Kuan , Pan Chih-Hong , Cheng Yawen , Chang Yu-Yin , Liou Saou-Hsing , Wang Jung-Der 
Published: December 2018

ObjectiveExposure to asbestos is the major cause for malignant pleural mesothelioma (MPM), but the causal link of individual cases is difficult to establish for lack of exposure information and long disease latency.MethodsWe established a retrospective cohort of workers employed in asbestos industries during the period of 1950–1989 and the occurrence of MPM during the period of 1980–2009 was examined with the Taiwan Cancer Registry. Estimated rate ratios (eRRs) were computed for each factory where any case of MPM was diagnosed by assuming Poisson distribution with a minimal latency of 20 years.ResultsA total of 18 MPM (17 males, 1 female) in eight factories were found. The incidence rate of MPM for the eight factories was 18.0 per million, ranging from 6.2 per million (military factory) to 268.2 per million (asbestos cement). We observed significantly increased risks for MPM in asbestos cement, thermal insulation and shipbuilding industries, with eRR (genders combined) of 113.6, 87.5 and 15.8, respectively. The sensitivity analyses considering latency showed similar findings in latency≥30 years, and the shipbuilding industry presented a significant eRR given a latency≥40 years. The gender-specific eRR showed similar results in men, but high eRR of 729.6 was observed in an asbestos cement factory where a female MPM was diagnosed.ConclusionsThis nationwide study in Taiwan comprehensively shows that different asbestos manufacturing processes, including asbestos cement, thermal insulation and shipbuilding industries, were at significantly increased risks for MPM. We recommend to establish a medical screening programme for workers previously exposed to asbestos to identify MPM and other asbestos-related diseases at an earlier stage.
Comparative survival and role of STS score in aortic paravalvular leak after SAVR or TAVR: a retrospective study from the USA
Authors: Padang Ratnasari , Ali Mahmoud , Greason Kevin L , Scott Christopher G , Indrabhinduwat Manasawee , Rihal Charanjit S , Eleid Mackram F , Nkomo Vuyisile T , Pellikka Patricia A , Pislaru Sorin V 
Published: December 2018

ObjectiveThe presence of aortic paravalvular leak (PVL) is associated with lower survival, but a direct comparison of its impact after transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR) has not been performed. This study sought to determine the differential influence of PVL on survival following TAVR versus SAVR and in patients with varying levels of risk as defined by the Society of Thoracic Surgeons (STS) risk score.MethodsPatients with and without postprocedural PVL were identified from 2290 patients undergoing TAVR or SAVR at Mayo Clinic between 2008 and 2014. The primary endpoint was overall survival.ResultsThere were 588 patients with PVL (374 TAVR, 214 SAVR): age 78±11 years, 63% male and mean follow-up of 3±2 years. PVL was trivial/mild in 442 (75%) patients. In propensity-matched analyses (n=86 per group), the overall survival at 1 and 4 years was 93% and 56% vs 89% and 61% in patients with PVL after TAVR versus SAVR, respectively (p=0.43). The presence or degree of PVL severity had no influence on survival of patients with high STS score (≥8%), while the presence of greater than mild PVL predicted worse survival in those with STS score <8%. During the first year after PVL diagnosis, while either improvement or stable PVL grade was seen in the majority of patients, worsening of PVL grade was more common in the TAVR group (19%) versus the SAVR group (4%) (p<0.0001).ConclusionsAt mid-term follow-up, the presence of PVL was associated with equally unfavourable outcomes following SAVR or TAVR. In patients with high STS risk score, the presence of PVL was not independently associated with increased mortality.
Evaluation of the safety of live attenuated influenza vaccine (LAIV) in children and adolescents with asthma and high-risk conditions: a population-based prospective cohort study conducted in England with the Clinical Practice Research Datalink
Authors: Caspard Herve , Steffey Amy , Mallory Raburn M , Ambrose Christopher S 
Published: December 2018

ObjectivesTo assess the safety of live attenuated influenza vaccine (LAIV) in children in high-risk groups.DesignNon-interventional cohort study.SettingEngland during 2013–2014 and 2014–2015 influenza seasons.ParticipantsLAIV recipients identified from the Clinical Practice Research Datalink, aged 2–17 years, and with at least one underlying high-risk condition. LAIV recipients were matched with inactivated influenza vaccine (IIV) recipients and unvaccinated controls.Primary outcome measuresPrimary safety endpoints were any hospitalisation documented in the linked Hospital Episodes Statistics database within 42 days and up to 6 months after vaccination.Results11 463 children and adolescents were included: 4718 received the trivalent LAIV formulation during the 2013–2014 influenza season and 6745 received the quadrivalent formulation during the 2014–2015 influenza season. The risks of hospitalisation within 42 days were 231 per 1000 person-years (95% CI 193 to 275) in season 2013–2014 and 231 (95% CI 198 to 267) in season 2014–2015. These risks were not significantly different when compared with matched unvaccinated children (relative risks (RR) 0.96 (95% CI 0.78 to 1.19) in season 2013–2014, 0.90 (95% CI 0.76 to 1.07) in season 2014–2015) and consistently lower than after IIV administration (RR 0.47 (95% CI: 0.37 to 0.59) in season 2013–2014, 0.42 (95% CI 0.35 to 0.51) in season 2014–2015). A similar pattern was observed up to 6 months postvaccination with a risk of hospitalisation after LAIV administration that did not differ from what was observed in unvaccinated controls and was lower than after IIV administration.ConclusionsThis study did not identify new safety concerns associated with the administration of LAIV in children and adolescents with high-risk conditions. However, as with any other observational study, treatment administration was not randomly assigned and our findings may be confounded by differences between the groups at baseline.Trial registration numberEUPAS18527.
Long-term urinary tract effect of ileal conduit after radical cystectomy compared with bladder preservation: a nationwide, population-based cohort study with propensity score-matching analysis
Authors: Liu Yu Liang , Luo Hao-Lun , Chiang Po-Huang , Chang Yen-Chen , Chiang Po-Hui 
Published: December 2018

ObjectiveIleal conduit urinary diversion (ICUD) is the most common procedure after radical cystectomy. Although complications have been reported, few patients with ICUD and bladder preservation controls have been available for long-term follow-up. This study compared the long-term effect of structural changes after cystectomy with ICUD to that in bladder preservation controls.DesignA retrospective nationwide cohort study.SettingData retrieved from the Taiwan National Health Insurance Research Database.ParticipantsThe National Health Insurance database was explored for patients diagnosed with bladder cancer between 1997 and 2006. Only cancer-free patients without chemotherapy and other types of urinary diversion who lived for >5 years were included in the analysis.Outcome measuresPatient characteristics, comorbidity and postoperative urinary tract disease were statistically analysed and compared. Cox proportional hazards model was used to evaluate the incidence rates of outcomes after adjustment for covariates. Propensity scores analysis was used to balance the clinical parameters between groups. The primary outcomes were postoperative new-onset urinary tract disease such as urinary tract infection (UTI), UTI with septicaemia and chronic kidney disease (CKD), or calculus of kidney and ureter.ResultsThere were 11 185 patients included in our cohort, among which 703 (6.3%) and 10 482 (93.7%) patients received ICUD and bladder preservation procedure, respectively. Compared with patients who only underwent a bladder preservation procedure, those who had undergone ICUD after cystectomy were independently associated with postoperative de novo urinary tract disease. Propensity score analysis (1:4) was also performed. ICUD contributed to significantly higher new-onset UTI, UTI with sepsis and CKD (HR=1.30, 3.16, 1.35, respectively) compared with bladder preservation procedure after adjustment for age, gender and comorbidities.ConclusionICUD after radical cystectomy was associated with a higher incidence of UTI, UTI with septicaemia and CKD during long-term follow-up than the incidences following a bladder preservation procedure.
Bariatric surgery among patients with heart failure: a systematic review and meta-analysis
Authors: Berger Sebastian , Meyre Pascal , Blum Steffen , Aeschbacher Stefanie , Ruegg Marco , Briel Matthias , Conen David 
Published: December 2018

BackgroundBariatric surgery reduces cardiovascular risk in obese patients. Heart failure (HF) is associated with an increased perioperative risk following bariatric surgery. This systematic review aimed to assemble the evidence on bariatric surgery in patients with known HF and the potential effect of bariatric surgery on incident HF in obese patients without prevalent HF.MethodsWe performed a comprehensive literature search up to 30 September 2017 and included studies comparing bariatric surgery to non-surgical treatment in patients with known presurgical HF. To assess whether bariatric surgery has any effect on incident HF, we also assembled studies looking at new-onset HF among patients without HF prior to surgery.ResultsWe found five observational studies (0 randomised trials) comparing bariatric surgery with non-surgical treatment in patients with a diagnosis of HF prior to surgery. A review of the available studies (n=676 patients) suggested reduced admission rates for HF exacerbation and increased left ventricular ejection fraction after bariatric surgery. No meta-analysis was possible due to the heterogeneous nature of these studies. Seven studies (one randomised trial) reported data on new-onset HF in obese patients without HF prior to bariatric surgery (n=111 127 patients). When comparing surgical to non-surgical treatment groups, the pooled univariable and multivariable HRs for incident HF were 0.28 (95% CI 0.13 to 0.55) and 0.44 (95% CI 0.36 to 0.55), respectively.ConclusionIn this systematic review, no randomised trial assessed the benefits and risks of bariatric surgery in obese patients with concomitant HF. Available studies do, however, show that surgery might prevent incident HF.
Addendum: “QCD parameters correlations from heavy quarkonia: αs(μ) from Mχ0c(0b) − Mηc(b) @ N2LO”
Authors: Narison Stephan 
Published: December 2018

This note complements the original paper QCD Parameters Correlations from Heavy Quarkonia1 where, here, we present a more detailed discussion of the [Formula: see text]-results obtained @ N2LO for two different subtraction scales [Formula: see text] from the (pseudo)scalar heavy quarkonia mass-splittings [Formula: see text]. This complementary discussion is useful for a much better understanding of these results.
An open-source realtime computational platform (short WIP paper)
Authors: Mehrotra Pavan , Dasgupta Sabar , Robertson Samantha , Nuyujukian Paul 
Published: December 2018

Systems neuroscience studies involving in-vivo models often require realtime data processing. In these studies, many events must be monitored and processed quickly, including behavior of the subject (e.g., movement of a limb) or features of neural data (e.g., a neuron transmitting an action potential). Unfortunately, most realtime platforms are proprietary, require specific architectures, or are limited to low-level programming languages. Here we present a hardware-independent, open-source realtime computation platform that supports high-level programming. The resulting platform, LiCoRICE, can process on order 10e10 bits/sec of network data at 1 ms ticks with 18.2 µs jitter. It connects to various inputs and outputs (e.g., DIO, Ethernet, database logging, and analog line in/out) and minimizes reliance on custom device drivers by leveraging peripheral support via the Linux kernel. Its modular architecture supports model-based design for rapid prototyping with C and Python/Cython and can perform numerical operations via BLAS/LAPACK-optimized NumPy that is statically compiled via Numba’s pycc. LiCoRICE is not only suitable for systems neuroscience research, but also for applications requiring closed-loop realtime data processing from robotics and control systems to interactive applications and quantitative financial trading.
Sex Disparities in Authorship Order of Cardiology Scientific Publications
Authors: Ouyang David , Sing David , Shah Sonia , Hu Jiaqi , Duvernoy Claire , Harrington Robert A. , Rodriguez Fatima 
Published: December 2018

Background:
Despite advances in the representation of women in medical training, women continue to be underrepresented in cardiology, academic medicine, and more specifically, in senior positions within academic medicine. Identifying disparities in research productivity and acknowledgment can highlight barriers to female representation in academic cardiology leadership, as well as in academic promotion.

Methods and Results:

This bibliometric analysis included all authors of original research articles between 1980 and 2017 from 3 high-impact cardiology journals (
Journal of the American College of Cardiology
,
Circulation
, and
European Heart Journal
). We identified 71 345 unique authors of 55 085 primary research articles during our study period. Female authors accounted for 33.1% of all authors; however, they represented only 26.7% of first authors and 19.7% of senior authors. Looking at the most prolific authors within this time period, female authors were not well represented, accounting for only 5% of the top 100 authors. Articles with a female senior author had more female middle authors than articles with a male senior author (mean 1.41 versus 0.97,
P
<0.001) and were more likely to have a female first author (0.37 versus 0.18,
P
<0.001). There was an increased representation of female authors as first and senior authors compared with the total number of articles with female authors over time (
P
<0.001 for trend); however, female senior authorship rates continued to lag first authorship rates.

Conclusions:
Using a large database of published manuscripts, we found that female representation in published cardiology research has increased over the past 4 decades. However, women continue to be not well represented as first authors, senior authors, and in the number of publications. When women were senior authors, they published more articles with female first authors and had more female authors. In addition to recruiting more women into the field of cardiology, additional work is needed to identify and address barriers to academic advancement for female physician-scientists.
Heart Failure With Preserved Ejection Fraction in the Young
Authors: Tromp Jasper , MacDonald Michael R. , Tay Wan Ting , Teng Tiew-Hwa K. , Hung Chung-Lieh , Narasimhan Calambur , Shimizu Wataru , Ling Lieng Hsi , Ng Tze Pin , Yap Jonathan , McMurray John J.V. , Zile Michael R. , Richards A. Mark , Anand Inder S. , Lam Carolyn S.P. 
Published: December 2018

Background:
Heart failure with preserved ejection fraction (HFpEF), traditionally considered a disease of the elderly, may also affect younger patients. However, little is known about HFpEF in the young.

Methods:
We prospectively enrolled 1203 patients with HFpEF (left ventricular ejection fraction ≥50%) from 11 Asian regions. We grouped HFpEF patients into very young (<55 years of age; n=157), young (55–64 years of age; n=284), older (65–74 years of age; n=355), and elderly (≥75 years of age; n=407) and compared clinical and echocardiographic characteristics, quality of life, and outcomes across age groups and between very young individuals with HFpEF and age- and sex-matched control subjects without heart failure.

Results:

Thirty-seven percent of our HFpEF population was <65 years of age. Younger age was associated with male preponderance and a higher prevalence of obesity (body mass index ≥30 kg/m
2
; 36% in very young HFpEF versus 16% in elderly) together with less renal impairment, atrial fibrillation, and hypertension (all
P
<0.001). Left ventricular filling pressures and prevalence of left ventricular hypertrophy were similar in very young and elderly HFpEF. Quality of life was better and death and heart failure hospitalization at 1 year occurred less frequently (
P
<0.001) in the very young (7%) compared with elderly (21%) HFpEF. Compared with control subjects, very young HFpEF had a 3-fold higher death rate and twice the prevalence of hypertrophy.

Conclusions:
Young and very young patients with HFpEF display similar adverse cardiac remodeling compared with their older counterparts and very poor outcomes compared with control subjects without heart failure. Obesity may be a major driver of HFpEF in a high proportion of HFpEF in the young and very young.
Gender Differences in Patient‐Reported Outcomes Among Adults With Atherosclerotic Cardiovascular Disease
Authors: Okunrintemi Victor , Valero‐Elizondo Javier , Patrick Benjamin , Salami Joseph , Tibuakuu Martin , Ahmad Saba , Ogunmoroti Oluseye , Mahajan Shiwani , Khan Safi U. , Gulati Martha , Nasir Khurram , Michos Erin D. 
Published: December 2018

Background

Atherosclerotic cardiovascular disease (
ASCVD
) accounts for approximately one third of deaths in women. Although there is an established relationship between positive patient experiences, health‐related quality of life, and improved health outcomes, little is known about gender differences in patient‐reported outcomes among
ASCVD
patients. We therefore compared gender differences in patient‐centered outcomes among individuals with
ASCVD
.

Methods and Results

Data from the 2006 to 2015 Medical Expenditure Panel Survey, a nationally representative US sample, were used for this study. Adults ≥18 years with a diagnosis of
ASCVD
, ascertained by
International Classification of Diseases, Ninth Revision
(
ICD‐9)
codes and/or self‐reported data, were included. Linear and logistic regression were used to compare self‐reported patient experience, perception of health, and health‐related quality of life by gender. Models adjusted for demographics, socioeconomic status, and comorbidities. There were 21 353 participants included, with >10 000 (47%‐weighted) of the participants being women, representing ≈11 million female adults with
ASCVD
nationwide. Compared with men, women with
ASCVD
were more likely to experience poor patient–provider communication (odds ratio 1.25 [95% confidence interval 1.11–1.41]), lower healthcare satisfaction (1.12 [1.02–1.24]), poor perception of health status (1.15 [1.04–1.28]), and lower health‐related quality of life scores. Women with
ASCVD
also had lower use of aspirin and statins, and greater odds of ≥2 Emergency Department visits/y.

Conclusions

Women with
ASCVD
were more likely to report poorer patient experience, lower health‐related quality of life, and poorer perception of their health when compared with men. These findings have important public health implications and require more research towards understanding the gender‐specific differences in healthcare quality, delivery, and ultimately health outcomes among individuals with
ASCVD
.
Lung Function in Young Adults and Risk of Cardiovascular Events Over 29 Years: The CARDIA Study
Authors: Cuttica Michael J. , Colangelo Laura A. , Dransfield Mark T. , Bhatt Surya P. , Rana Jamal S. , Jacobs David R. , Thyagarajan Bharat , Sidney Stephen , Lewis Cora E. , Liu Kiang , Lloyd‐Jones Donald , Washko George , Kalhan Ravi 
Published: December 2018

Background
Diminished peak lung function in young adulthood is a risk factor for future chronic obstructive pulmonary disease. The association between lung disease and cardiovascular disease later in life is well documented. Whether peak lung function measured in young adulthood is associated with risk of future cardiovascular events is unknown.

Methods and Results

CARDIA (The Coronary Artery Risk Development in Young Adults) study is a prospective, multicenter, community‐based, longitudinal cohort study including 4761 participants aged 18 to 30 years with lung function testing we investigated the association between lung health in young adulthood and risk of subsequent cardiovascular events. We performed Cox proportional hazards regression to test the association between baseline and years 10 and 20 pulmonary function with incident cardiovascular events. Linear and logistic regression was performed to explore the associations of lung function with development of risk factors for cardiovascular disease as well as carotid intima‐media thickness and coronary artery calcified plaque. At baseline, mean age (±
SD
) was 24.9±3.6 years. Baseline forced expiratory volume in 1 second (hazard ratio) per −10‐unit decrement in percent predicted forced expiratory volume in 1 second (hazard ratio, 1.18; 95% CI, 1.06–1.31 [
P
=0.002]) and
FVC
per −10‐unit decrement in percent predicted
FVC
(hazard ratio, 1.19; 95% CI, 1.06–1.33 [
P
=0.003]) were associated with future cardiovascular events independent of traditional cardiovascular risk factors. Baseline lung function was associated with heart failure and cerebrovascular events but not coronary artery disease events.

Conclusions
Lung function in young adulthood is independently associated with cardiovascular events into middle age. This association appears to be driven by heart failure and cerebrovascular events rather than coronary heart disease.

Clinical Trial Registration

URL
:
https://www.clinicaltrials.gov
. Unique identifier:
NCT
00005130.
Early Mercian Text Production: Authors, Dialects, and Reputations
Authors: Rauer Christine 
Published: December 2018

Abstract
There are suggestions that King Alfred’s legendary literary renaissance may have been a reaction to the efforts of the neighbouring kingdom of Mercia. According to Asser, Alfred assembled a group of literary scholars from this rival Mercian tradition at his court. But it is not clear what early literary activities these scholars could have been involved in to justify their pre-Alfredian reputation. This article tries to outline the historical and literary evidence for early Mercian text production, and the importance of this ‘other’ early literary corpus. What is our current knowledge of Mercian text production and the political and literary relationship of Mercia with Canterbury? What was the relationship of Alfred’s educational movement with its Mercian forerunner? Why is modern scholarship better informed about Alfred’s movement than any Mercian rival culture? If our current knowledge of this area is insufficient for the writing of a literary history of Mercia, a provisional list of texts and bibliography, published electronically for convenient updating, may prove useful in the meantime.
Old English būtan / Old Frisian būta: From Adverb to Conjunction
Authors: Bremmer Rolf H. 
Published: December 2018

Abstract
It is well established that Old English is more closely related to Old Frisian than to any other West Germanic language. This fact rests especially on phonological, morphological and lexical evidence. Syntactic arguments are few and far between. In this article, the author argues that the Old Frisian conjunction būta ‘but’ and its Old English parallel būtan ‘but’ do not derive their behavioural similarities to an erstwhile Anglo-Frisian pre-stage, but must be explained as having arisen from a similar, but independent, process of grammaticalization.