bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subtyping salivary gland neoplasm of uncertain malignant potential based on cell type demonstrates differential risk of malignancy
Authors: Hang Jen‐Fan , Alruwaii Fatimah , Zeng Bao‐Rung , Lai Chiung‐Ru , Wu Howard H. 
Published: October 2018

BACKGROUNDThe newly unveiled Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has proposed salivary gland neoplasm of uncertain malignant potential (SUMP) as an indeterminate category. The category is reserved for fine‐needle aspiration (FNA) cases that are diagnostic of a salivary gland neoplasm but cannot be further designated as a specific tumor type. The objective of the current study was to evaluate the clinical utility of subtyping SUMP cases based on different cell types.METHODSA retrospective search of cytology databases at 2 institutions for salivary gland FNAs from 2006 through 2017 was conducted. The cytologic diagnosis of each case was reclassified according to the MSRSGC. Histologic follow‐up was retrieved for correlation. Cases reclassified as SUMP that had a follow‐up pathologic diagnosis were subject to cytology review and subtyping into oncocytic/squamoid, basaloid, or myoepithelial subtypes based on cytomorphology. The risk of malignancy (ROM) for each subtype was analyzed.RESULTSThere were 92 SUMP cases, which comprised 5.9% of 1560 consecutive salivary gland FNAs within the 12‐year study period. Histologic follow‐up was available for 59 patients. After cytology review, there were 18 cases (30.5%) of oncocytic/squamoid subtype, 25 (42.4%) of basaloid subtype, and 16 (27.1%) of myoepithelial subtype. Pathologic correlation revealed an ROM of 61.1% (11 of 18 cases) for the oncocytic/squamoid subtype, 40.0% (10 of 25 cases) for the basaloid subtype, and 18.8% (3 of 16 cases) for the myoepithelial subtype. The differences in ROM among the 3 subtypes were statistically significant (P = .0476).CONCLUSIONSSubtyping SUMP cases into categories based on cell type demonstrated differential ROMs for better clinical stratification. Future prospective studies are mandatory to confirm this finding.
Copper‐Nanocluster‐Based Transparent Ultraviolet‐Shielding Polymer Films
Authors: Shi Yu‐e , Zhuang Xuming , Cao Lili , Gou Siyu , Xiong Yuan , Lai Wing‐Fu , Wang Zhenguang , Rogach Andrey L. 
Published: October 2018

AbstractTransparent, utraviolet (UV) shielding composite materials, which combine the polymer matrix and organic or inorganic UV absorbers, are attractive for packaging industry. Many of these composite films are still suffering from several issues, such as low stability, toxicity of the UV absorbers, and light scattering caused by aggregation. We introduce UV shielding films fabricated by using copper nanoclusters embedded in the polymer framework of the cross‐linked polyvinyl alcohol and polyvinylpyrrolidone. Such composite films show a high UV shielding ability, and allow for transmittance of light in the visible range; they possess favourable mechanical properties (flexibility), thermal stability, and stability against UV light exposure. Potential applicability of the films is demonstrated through protection of Rhodamine B dye from photodegradation.
Primary breast lymphoma: A single‐centre experience
Authors: Foo Mang Yik , Lee Wai Peng , Seah Chin Mui Jaime , Kam Carmen , Tan Su‐Ming 
Published: October 2018

AbstractBackgroundPrimary non‐Hodgkin lymphoma is an extremely rare entity, and this condition represents less than 0.5% of all malignant lesions involving the mammary gland. As such, there has been a paucity of relevant clinical data arising from Southeast Asia.AimsOur study aims to review the clinical presentation, diagnostic methods, treatment, and survival outcomes of all patients diagnosed with primary breast lymphoma in our institution between 2011 and 2017.Methods and resultsPatients who had histologically proven lymphoma involving the breast were identified from a prospectively collected database in a single institution between 2011 and 2017. All seven patients were female, with a median age of 65 years old, and had presented with unilateral large breast or axillary masses. All the histological diagnosis was achieved with adequate tissue diagnosis either through core, incisional, or excisional biopsy. Five patients had diffuse large B cell lymphoma, one had marginal zone lymphoma, and the other had follicular lymphoma. Based on Ann Arbor classification, one patient had stage 1, three had stage 2, one with stage 3, and two patients with stage 4 disease. Five patients had received standard CHOP regimen with rituximab. At the time of analysis, patients who had nondisseminated disease had a median survival of 57 months. The overall mean survival time for all seven patients was 47 months. With the standard systemic chemotherapy treatment regimen, the estimated 3‐year overall survival was found to be 64%.ConclusionPrimary breast lymphoma, though uncommon, may present in a similar manner as breast carcinomas, but the main treatment modality remains nonsurgical with systemic chemotherapy. Hence, it is prudent to obtain accurate histological diagnosis of primary breast lymphoma. In this study, our patients with nondisseminated breast lymphoma have demonstrated a fairly good survival outcome following chemotherapy.
K‐M theory of fabric knitted by three‐channel rotor spun wool yarn
Authors: Yang Ruihua , Xu Yaya , Deng Qianqian , Xie Chunping , Gao Weidong 
Published: October 2018

AbstractTwo‐component and three‐component color blended yarns were spun by red, yellow, and blue wool slivers using a three‐channel rotor spun machine, and the corresponding plain fabrics were knitted. The color‐matching models of K‐M theory were built with the relative method and the least squares method, respectively. Colors and blending ratios of the fabrics were predicted by the model. The results showed that the average color differences of the samples predicted by the two methods are both about 1.0 and the mean value of the proportional error is below 3%. The least squares method has a better color‐matching effect for the three‐component sample, and the relative value method has better color‐matching results for the two‐component sample. When the tolerance range is 2.0, the pass rates of the samples predicted by either the relative value method or the least squares method reach 100%.
Analysis on profit model of multi‐information products logistics using evolutionary game algorithm
Authors: Yang Bo 
Published: October 2018

SummaryAgricultural products logistics finance warehouse business mainly includes three parties: agricultural production and processing enterprises and the third‐party logistics enterprises and financial institutions, to allow three parties to achieve a win‐win situation; in this paper, the evolutionary game theory is used to construct the evolutionary game model of three‐party selection different strategies and, through the construction of replicated dynamic equation, solving the evolution stable strategy. At last, based on the evolutionary stable point, the paper analyzes the strategies of agricultural production and processing enterprises, the third‐party logistics enterprises and financial institutions, and gives the feasible suggestions to the three‐party strategy. Realization of agricultural products logistics finance warehouse profit model three‐party mutual benefit and win‐win, so as to promote the smooth development of agricultural products logistics financial business, ensure the cooperation and common development of agricultural production and processing enterprises and the third‐party logistics enterprises.
Attribute importance measurement based on the data effect and its performance analysis in computation practice
Authors: Li Fachao , Jin Chenxia , Zhang Xiao 
Published: October 2018

SummaryAttribute importance measurement is the core of multi‐attribute decision making. This study aims at resolving the problem of attribute importance computation. Based on the data system and the inclusion degree of sets, we propose a data deletion method based on knowledge reliability. By taking the hidden knowledge in the data system as the carrier, we further discuss the changing rules of knowledge factors in the subsystems and propose an attribute importance measurement method based on the data effect (abbreviated DE‐AIM). Furthermore, we analyze the values and structure features of DE‐AIM through a theoretical proof and an example calculation. Finally, we compare DE‐AIM with other attribute importance measurements by combining with concrete cases and several data sets from UCI. All the results indicate that DE‐AIM not only has good structural features and interpretability but also can reflect different decision preference by changing parameters. The method has wide applications in many fields such as resource management, artificial intelligence, complex system optimization, expert systems, and concurrency computation.
Scanning Fluorescence Correlation Spectroscopy for Quantification of the Dynamics and Interactions in Tube Organelles of Living Cells
Authors: Unsay Joseph D. , Murad Fabronia , Hermann Eduard , Ries Jonas , García‐Sáez Ana J. 
Published: October 2018

AbstractSingle‐molecule spectroscopic quantification of protein‐protein interactions directly in the organelles of living cells is highly desirable but remains challenging. Bulk methods, such as Förster resonance energy transfer (FRET), currently only give a relative quantification of the strength of protein‐protein interactions. Here, we introduce tube scanning fluorescence cross‐correlation spectroscopy (tubeSFCCS) for the absolute quantification of diffusion and complex formation of fluorescently labeled molecules in the mitochondrial compartments. We determined the extent of association between the apoptosis regulators Bcl‐xL and tBid at the mitochondrial outer membrane of living cells and discovered that practically all mitochondria‐bound Bcl‐xL and tBid are associated with each other, in contrast to undetectable association in the cytosol. Furthermore, we show further applicability of our method to other mitochondrial proteins, as well as to proteins in the endoplasmic reticulum (ER) membrane.
Tuning the Porosity and Photocatalytic Performance of Triazine‐Based Graphdiyne Polymers through Polymorphism
Authors: Schwarz Dana , Acharjya Amitava , Ichangi Arun , Kochergin Yaroslav S. , Lyu Pengbo , Opanasenko Maksym V. , Tarábek Ján , Vacek Chocholoušová Jana , Vacek Jaroslav , Schmidt Johannes , Čejka Jiří , Nachtigall Petr , Thomas Arne , Bojdys Michael J. 
Published: October 2018

AbstractCrystalline and amorphous organic materials are an emergent class of heterogeneous photocatalysts for the generation of hydrogen from water, but a direct correlation between their structures and the resulting properties has not been achieved so far. To make a meaningful comparison between structurally different, yet chemically similar porous polymers, two porous polymorphs of a triazine‐based graphdiyne (TzG) framework are synthesized by a simple, one‐pot homocoupling polymerization reaction using as catalysts CuI for TzGCu and PdII/CuI for TzGPd/Cu. The polymers form through irreversible coupling reactions and give rise to a crystalline (TzGCu) and an amorphous (TzGPd/Cu) polymorph. Notably, the crystalline and amorphous polymorphs are narrow‐gap semiconductors with permanent surface areas of 660 m2 g−1 and 392 m2 g−1, respectively. Hence, both polymers are ideal heterogeneous photocatalysts for water splitting with some of the highest hydrogen evolution rates reported to date (up to 972 μmol h−1 g−1 with and 276 μmol h−1 g−1 without Pt cocatalyst). Crystalline order is found to improve delocalization, whereas the amorphous polymorph requires a cocatalyst for efficient charge transfer. This will need to be considered in future rational design of polymer catalysts and organic electronics.
Heterostructured d‐Ti3C2/TiO2/g‐C3N4 Nanocomposites with Enhanced Visible‐Light Photocatalytic Hydrogen Production Activity
Authors: Zhang Mengyuan , Qin Jiaqian , Rajendran Saravanan , Zhang Xinyu , Liu Riping 
Published: October 2018

AbstractThe construction of a 2D–2D heterostructured composite is an efficient method to improve the photocatalytic hydrogen generation capability under visible light. In this work, simple heat treatment of a mixture of g‐C3N4 and delaminated Ti3C2 was used to prepare a series of d‐Ti3C2/TiO2/g‐C3N4 nanocomposites. The d‐Ti3C2 not only acted as the support layer and resource to glue the anatase TiO2 particles and g‐C3N4 layers together but also served as the fast electron transfer channel to improve the photogenerated charge carriers’ separation efficiency. By tuning the g‐C3N4/d‐Ti3C2 mass ratio, heating temperature and soaking time, the d‐Ti3C2/TiO2/g‐C3N4 nanocomposite 4‐1‐350‐1 achieved an excellent H2 evolution rate of 1.62 mmol h−1 g−1 driven by a 300 W Xe lamp with a 420 nm cutoff filter. The heterostructured composite photocatalyst was stable even after 3 cycles, representing excellent potential for the practical application in solar energy conversion.
Quantification and phenotypic characterization of peripheral blood Vδ1 + T cells in chronic lymphocytic leukemia and monoclonal B cell lymphocytosis
Authors: Simões Catarina , Silva Isabel , Carvalho Anabela , Silva Sandra , Santos Susana , Marques Gilberto , Ribeiro André , Roque Adriana , Carda José , Sarmento‐Ribeiro A.B. , Domingues Maria do Rosário , Ribeiro Letícia , Paiva Artur 
Published: October 2018

BackgroundVδ1+ T cells, a subset of γδ T cells, are responsible for innate‐like immune responses. Recently, an anti‐tumor function mediated by MHC‐unrestricted recognition of lipid and stress molecules, has also been described in these cells. This study aimed to quantify and phenotypically characterize circulating Vδ1+ T cells in B cell Chronic Lymphocytic Leukemia (CLL) and Monoclonal B cell lymphocytosis (MBL).MethodsThis study enrolled 58 individuals distributed in five groups: Binet B and C CLL (n = 9), Binet A CLL (n = 26), High count‐MBL (n = 10), Low count‐MBL (n = 5), and a control group (n = 8). The phenotypic characterization of Vδ1+ T cells, as well as the other T cell subpopulations (CD4+, CD8+, CD4+/CD8+, and Vδ1− γδT cells), were assessed by flow cytometry, evaluating the frequency of each subset expressing CD27, CD69, and cytoplasmic granzyme B.ResultsWe observed an increasing percentage of Vδ1+ T cells belonging to CD27− compartment from controls to advanced stages of the disease, which was accompanied by an increasing percentage of these cells expressing granzyme B, a phenotypic pattern that was also observed in the other T cell subpopulations under study since earlier stages of the disease. Moreover, a striking expansion of Vδ1+ T cells in Binet B and C CLL was observed.ConclusionsThese experiment findings point to an expansion of CD27‐Vδ1+ T cells with a cytotoxic profile, from controls to advanced stages of the disease, which points to a role of Vδ1+ T cells in the host's anti‐tumor responses against clonal B‐cells in MBL and CLL. © 2018 Clinical Cytometry Society
Energy Analysis of Fuel Cell Electric Vehicles (FCEVs) under European Weather Conditions and Various Driving Behaviors
Authors: Hollweck B. , Moullion M. , Christ M. , Kolls G. , Wind J. 
Published: October 2018

AbstractDue to the auxiliary loads' increasing influence on the overall energy consumption of electrified vehicles, a holistic tank‐to‐wheel analysis is necessary. To do so, the impact of the auxiliary load on the energy consumption of a fuel cell electric vehicle (FCEV) drivetrain is investigated by taking different driving behaviors and three European environmental conditions (Spanish, German and Norwegian weather profiles) into account. The driving pattern is analyzed with the study ‘Mobilität in Deutschland' [1] and represented with the Artemis driving cycles [2]. To match various situations of the everyday life, realistic boundary conditions are determined by five starting times. The corresponding weather conditions are obtained and five weather profiles for every meteorological season including the ambient temperature, solar flux and humidity are considered. By using a complete FCEV simulation model, a realistic energy consumptions is simulated and the impact of different climate conditions as well as driving behaviors is investigated. As a result, a significant influence of the auxiliary load on the overall energy consumption is detected and the need to consider the overall energy demand is demonstrated.
Compositions and Structures of Zeolitic Imidazolate Frameworks
Authors: Noh Kyungkyou , Lee Jisu , Kim Jaheon 
Published: October 2018

AbstractZeolitic imidazolate frameworks (ZIFs), which are composed of point metal centres and imidazolate linkers, can adopt numerous three‐dimensional structures. Their unique structures and porosity properties make ZIFs promising materials especially for gas separation applications. Recently their unusual phase transition properties are getting research attention rapidly. Indeed, all the properties of ZIFs are dependent on their structures. Although some empirical rules are known for discovering new ZIFs, still scientific intuition and trials are necessary to find proper reaction conditions. Also, practical information should be extracted from the accumulate achievements and in turn, applied to further exploration. In this regard, this article analyses the structures, compositions, and porosity of known ZIFs, where the relationship between imidazolates and topologies is described in detail.
PML/RARa blocks the differentiation and promotes the proliferation of acute promyelocytic leukemia through activating MYB expression by transcriptional and epigenetic regulation mechanisms
Authors: Wang Genjie , Tian Ying , Hu Qingzhu , Xiao Xichun , Chen Shuxia 
Published: October 2018

AbstractThe promyelocytic leukemia (PML)/retinoic acid receptor‐alpha (RARα) onco‐fusion protein that is generated from t(15;17) chromosome translocation is crucial for the leukemogenesis of acute promyelocytic leukemia (APL) and is well documented as a transcriptional repressor. To understand the relationship between PML/RARα and the oncogene in the development of APL, we investigate the regulation mechanism of PML/RARα to MYB proto‐oncogene and the role of this regulation on the proliferation and differentiation of APL cells. Reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) assays show that MYB expression was significantly higher in PML/RARα positive cell lines. Microarray data verify that the MYB expression was significantly higher in APL patient samples than in normal promyelocyte samples. Further expression analysis from RT‐qPCR and microarray data verifies that the expression of MYB is upregulated by PML/RARα. Transcriptional factor binding analysis shows that MYB is directly bound by PML/RARα and its cofactors. Luciferase assays show that PML/RARα transactivated MYB promoter activity through the RARα binding site and the coexistence of CCAAT enhancer binding protein ε. We also find that PML/RARα increases the acetylation level of the promoter region of MYB. Further evidence demonstrates that PML/RARα regulates MYB expression through long‐range interaction. Functionally, PML/RARα increases the cell proliferation and blocks the differentiation through activating MYB expression. Collectively, this study uncovers a novel mechanism of PML/RARα‐mediated transcriptional activation and enriches our knowledge of the onco‐fusion protein‐mediated transcription activation.
Expression of osteoprotegerin and receptor activator for the nuclear factor‐κB ligand in XACB/LV‐bFGF/MSCs transplantation for repair of rabbit femoral head defect necrosis
Authors: Peng Wuxun , Zhang Jian , Zhang Fei , Zhao Yin , Dong Wentao 
Published: October 2018

AbstractThe aim of this study is to observe the changes in osteoprotegerin (OPG) and receptor activator for the nuclear factor‐κB ligand (RANKL) in a rabbit model, and to explore the therapeutic effect of tissue engineering bone on femoral head necrosis. A total of 60 rabbits were randomly divided into 5 groups. The necrosis model of femoral head defects was created by dexamethasone combined with a horse serum injection. The model of femoral head necrosis was reconstructed by tissue engineering bone. The protein expressions of OPG and RANKL were detected by Western blot analysis. The expression of OPG and the RANKL protein in group E was higher than that in the other 4 groups (P < .05); there was no significant difference between groups C and D (
P > .05). The expression of OPG protein in the rabbit femoral head necrosis group was improved by xenogeneic antigens of cancellous bone/lentiviral‐basic fibroblast growth factor/mesenchymal stem cells, which were expected to be used as an effective tissue engineering material to repair the necrosis of the femoral head.
Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk
Authors: Tang Weifeng , Chen Shuchen , Liu Jun , Liu Chao , Wang Yafeng , Kang Mingqiang 
Published: October 2018

AbstractEsophagogastric junction adenocarcinoma (EGJA) may be associated with obesity and overweight. Thus, any variant in energy metabolism–related gene may influence the development of EGJA. In this study, we recruited 720 EGJA cases and 1541 noncancer controls. We selected IGF2BP2 rs4402960 G > T, rs1470579 A > C,
IGF1 rs5742612 A > G and
IGFBP3 rs3110697 G > A, rs2270628 C > T and rs6953668 G > A loci and assessed the relationship of these polymorphisms with lymph node status and susceptibility of EGJA. We found that
IGF2BP2 rs1470579 A > C and
IGFBP3 rs6953668 G > A polymorphisms were associated with the decreased risk of EGJA (
IGF2BP2 rs1470579: CC vs AA: adjusted odds ratio [OR] = 0.65, 95% confidence interval [CI] = 0.43‐0.98,
P = 0.041 and CC vs AA/AC: adjusted OR = 0.62, 95% CI = 0.41‐0.93,
P = 0.021 and
IGFBP3 rs6953668: GA vs GG: adjusted OR = 0.66, 95% CI = 0.47‐0.93,
P = 0.019 and GA/AA vs GG: adjusted OR = 0.68, 95% CI = 0.48‐0.95,
P = 0.026). However, we also found that
IGF1 rs5742612 A > G polymorphism increased the risk of LNM among patients with EGJA (GG vs AA: adjusted OR = 1.88, 95% CI = 1.02‐3.46,
P = 0.042 and GG vs AA/AG: adjusted OR = 1.92, 95% CI = 1.06‐3.47,
P = 0.032). This study suggests that
IGF2BP2 rs1470579 A > C and
IGFBP3 rs6953668 G > A polymorphisms may decrease genetic susceptibility to EGJA in eastern Chinese Han population. In addition, our findings also indicate that
IGF1 rs5742612 A > G polymorphism may increase the susceptibility of LNM among patients with EGJA.
Effects of inflammatory cytokines on bone/cartilage repair
Authors: Zhang Tingshuai , Yao Yongchang 
Published: October 2018

AbstractMany inflammatory factors can affect cell behaviors and work as a form of inter‐regulatory networks through the inflammatory pathway. Inflammatory cytokines are critical for triggering bone regeneration after fracture or bone injury. Also, inflammatory cytokines play an important role in cartilage repair. The synergistic or antagonistic effects of both proinflammatory and anti‐inflammatory cytokines have a great influence on fracture healing. This review discusses key inflammatory cytokines and signaling pathways involved in bone or cartilage repair.