bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of big data analytics management capabilities on supply chain preparedness, alertness and agility
Authors: Mandal Santanu 
Published: August 2018

PurposeThe importance of big data analytics (BDA) on the development of supply chain (SC) resilience is not clearly understood. To address this, the purpose of this paper is to explore the impact of BDA management capabilities, namely, BDA planning, BDA investment decision making, BDA coordination and BDA control on SC resilience dimensions, namely, SC preparedness, SC alertness and SC agility.Design/methodology/approachThe study relied on perceptual measures to test the proposed associations. Using extant measures, the scales for all the constructs were contextualized based on expert feedback. Using online survey, 249 complete responses were collected and were analyzed using partial least squares in SmartPLS 2.0.M3. The study targeted professionals with sufficient experience in analytics in different industry sectors for survey participation.FindingsResults indicate BDA planning, BDA coordination and BDA control are critical enablers of SC preparedness, SC alertness and SC agility. BDA investment decision making did not have any prominent influence on any of the SC resilience dimensions.Originality/valueThe study is important as it addresses the contribution of BDA capabilities on the development of SC resilience, an important gap in the extant literature.
Perception, usage and barriers towards the utilisation of the Telecentre among rural women in Tanzania
Authors: Lwoga Edda Tandi , Chigona Wallace 
Published: August 2018

Purpose
This paper aims to assess the usage pattern of telecentres, how rural women frame telecentres and barriers that limit use of telecentres. Further, the study examined the effects of demographic characteristics and location on telecentre usage.

Design/methodology/approach
The study used a sequential mixed research design in three rural districts surrounding telecentres: Kongwa, Sengerema and Kilosa districts. The study population comprised rural women who were users and non-users of telecentres. The study conducted six focus group discussions (FGDs) with 37 users and six FGDs with 36 non-users in the first phase of the study in 2014; questionnaires were administered to 90 users and 90 non-users in the second phase of the study in 2015.

Findings
The primary use of telecentres among users was to access internet (71.4 per cent, n = 60), followed by information and communication technology (ICT) training courses (63.1 per cent, n = 53) and secretarial purposes (63.1 per cent, n = 53). Rural women used internet for educational purposes, followed by news, information on health issues, job opportunities, social and entertainment issues. Rural women currently using internet were more likely to be better educated (ß = 1.926, p = 0.001) and have higher incomes (ß = 5.318, p = 0.021) at both bivariate and multivariate analysis. Users indicated that they faced the following barriers towards using telecentre: short duration of ICT training, frequent power outages, low speed of internet and few computers at the telecentres. Non-users were not using telecentres because of lack of ICT skills and language barriers.

Originality/value
This study provides empirical evidence to telecentres, libraries and other rural ICT initiatives to design rural ICT services that are gender-sensitive and demand-driven.
Residential mortgages, the real estate market, and economic growth: evidence from Europe
Authors: Filotto Umberto , Giannotti Claudio , Mattarocci Gianluca , Scimone Xenia 
Published: August 2018

Purpose
The purpose of this paper is to evaluate the impact of macroeconomic condition and real estate price trend on the amount of residential loan.

Design/methodology/approach
The paper using a sample of 16 European Countries for the time period 2007–2015 evaluates the impact of change in the gross domestic product (GDP) growth and the inflation rate on the amount of residential loans. The analysis is performed by using a vector autoregressive (VAR) and generalized VAR approach for the full sample and for each country considered.

Findings
For a short-term horizon, shocks to mortgages, the house price index (HPI) and the GDP have a positive effect on the GDP, a shock to the amount of mortgages has a positive effect on the mortgage supply and a shock to the GDP has a negative effect on HPI. The main results for the long-term horizon are that a GDP shock has a positive and persistent effect on the amount of mortgages, a shock to HPI has a negative and persistent effect on mortgages and a shock to the amount of mortgages seems to have no persistent effect on the GDP or the HPI. Moreover, the analysis shows that a spillover risk among countries exists and a GDP shock in a European area has an effect on the GDP, real estate prices and residential mortgages in almost all European countries.

Practical implications
Results obtained show that both macroeconomic and housing prices shocks matter for the real estate lending and the effect are different in the short- and in the medium–long-term horizon. Results are also different country by country and they are affected by the level of financial development of the country.

Originality/value
The paper studies a lending crisis period and evaluates for the European market the impact of shock on macro-variables for mortgages focusing the attention for the first time only on residential mortgages.
Mitochondrial genome, comparative analysis and evolutionary insights into the entomopathogenic fungus Hirsutella thompsonii
Authors: Wang Lin , Zhang Shu , Li Jian‐Hui , Zhang Yong‐Jie 
Published: August 2018

SummaryNuclear genomes of two isolates of Hirsutella thompsonii, a pathogen causing epizootics among mites, have been reported; in contrast, its mitochondrial genome (mitogenome) has remained unknown, limiting our understanding of its evolution. Herein, we annotated the first complete mitogenome of H. thompsonii, which encoded all standard fungal mitochondrial genes plus three free‐standing ORFs. Transcriptional analyses validated the expression of most conserved genes and revealed some interesting transcription patterns of mitochondrial genes. Phylogenetic analyses confirmed its placement in Ophiocordycipitaceae. Comparison of five different isolates originally collected from different locations revealed mitogenome size variations (60.3–66.4 kb) mainly due to different numbers of introns. A total of 15 intron loci were identified, with 11 existing in all 5 isolates and 4 showing presence/absence dynamics. These introns were most likely obtained through horizontal transfer from other fungal organisms. Those common introns might have been in H. thompsonii mitogenomes since the divergence of the fungus from its putative sister species H. minnesotensis, whereas those dynamic introns might have experienced 1–2 gain or loss events. We also detected evidence of degeneration for some introns. Overall, our study shed new insights into the mitochondrial evolution of the acaropathogenic fungus H. thompsonii.
Desulfitobacterium contributes to the microbial transformation of 2,4,5‐T by methanogenic enrichment cultures from a Vietnamese active landfill
Authors: Lechner Ute , Türkowsky Dominique , Dinh Thi Thu Hang , Al‐Fathi Hassan , Schwoch Stefan , Franke Stefan , Gerlach Michelle‐Sophie , Koch Mandy , von Bergen Martin , Jehmlich Nico , Dang Thi Cam Ha 
Published: August 2018

SummaryThe herbicide 2,4,5‐trichlorophenoxyacetic acid (2,4,5‐T) was a major component of Agent Orange, which was used as a defoliant in the Vietnam War. Little is known about its degradation under anoxic conditions. Established enrichment cultures using soil from an Agent Orange bioremediation plant in southern Vietnam with pyruvate as potential electron donor and carbon source were shown to degrade 2,4,5‐T via ether cleavage to 2,4,5‐trichlorophenol (2,4,5‐TCP), which was further dechlorinated to 3,4‐dichlorophenol. Pyruvate was initially fermented to hydrogen, acetate and propionate. Hydrogen was then used as the direct electron donor for ether cleavage of 2,4,5‐T and subsequent dechlorination of 2,4,5‐TCP. 16S rRNA gene amplicon sequencing indicated the presence of bacteria and archaea mainly belonging to the Firmicutes, Bacteroidetes, Spirochaetes, Chloroflexi and Euryarchaeota. Desulfitobacterium hafniense was identified as the dechlorinating bacterium. Metaproteomics of the enrichment culture indicated higher protein abundances of 60 protein groups in the presence of 2,4,5‐T. A reductive dehalogenase related to RdhA3 of D. hafniense showed the highest fold change, supporting its function in reductive dehalogenation of 2,4,5‐TCP. Despite an ether‐cleaving enzyme not being detected, the inhibition of ether cleavage but not of dechlorination, by 2‐bromoethane sulphonate, suggested that the two reactions are catalysed by different organisms.
Streamflow Alteration from Impervious Cover: Are All Watersheds Created Equal?
Authors: Moltz Heidi L.N. , Palmer James B. , Smith Zachary M. 
Published: August 2018

AbstractVery small amounts of impervious cover can impact streamflows. In the Potomac basin, for example, significant streamflow alteration associated with watershed impervious cover >0.5%–2.0% have been found. Since these impacts were found with considerably lower amounts of impervious cover than previously documented in the literature, typically 10%–20%, this study evaluated whether certain watershed characteristics (e.g., watershed area, karst geology, precipitation, soil characteristics, physiographic province, and slope) make a stream reach more susceptible to the impacts of impervious cover than others. The results of this study indicate there are differences in streamflow sensitivity to impervious cover given certain landscape characteristics. The relationships of watershed characteristics with streamflow alteration in flashiness, high flow duration, and low pulse duration were evaluated. Flashiness alteration was positively correlated with impervious cover and influenced by watershed slope and area. High flow duration alteration was negatively correlated with impervious cover and influenced by mean annual precipitation and slope. Low pulse duration was poorly correlated with the watershed characteristics under consideration. These differences may assist in land management efforts and heighten awareness of the environmental impacts of impervious cover.
Multiple myocardial bridges associated with left‐ventricular dysfunction, intermittent left bundle branch block, and cardiac memory: A case report
Authors: Ibarrola Martin 
Published: August 2018

AbstractMyocardial bridges are a congenital anomaly in which a segment of the coronary artery takes a “tunneled” intramuscular course. Few reports have associated myocardial bridges with left‐ventricular dysfunction in patients with ischemia. Intermittent left bundle branch block is a conduction disturbance that has been described to be associated with myocardial bridges and cardiac memory. This study reports unusual associations of multiple myocardial bridges, angina, left‐ventricular dysfunction, intermittent left bundle branch block, and cardiac memory.
General Surgery Prioritization Tool: a pilot study
Authors: Hunter Rachel J. , Buckley Nicholas , Fitzgerald Eve L. , MacCormick Andrew D. , Eglinton Tim W. 
Published: August 2018

BackgroundThe prioritization of elective surgical wait‐lists remains a contentious issue. Multiple new tools and systems have been developed to attempt to reliably prioritize patients. This study pilots one such system, the General Surgery Prioritization Tool and compares it to the existing triage system of clinical judgement. The aim was to determine if the new tool reflects clinical judgement. Secondary aims were to assess for any bias in its application to different patient groups or its application by different scorers.MethodA cohort of 392 patients was identified who were wait‐listed for non‐cancer elective surgery between July 2015 and February 2016. The General Surgery Prioritization Tool was applied after traditional prioritization using clinical judgement. The scores produced by the new tool were compared to the clinical judgement categories. Differences in scores based on gender, ethnicity, age, surgical condition and surgeon were then analysed.ResultsThere was statistically significant correlation in the new tool scores with traditional triage groups (P < 0.0001). There were no statistically significant differences in mean scores attributable to gender, age or ethnicity. There were minimal differences in mean scores between common surgical conditions. Except for one outlier the mean scores were consistent across 17 surgeons.ConclusionThis pilot study has found the General Surgery Prioritization Tool to reflect clinical judgement and to be generalizable by age, gender, ethnicity and prioritizing surgeon. The tool is at least as clinically reliable as traditional methods in the triage for elective general surgery with the advantage of being a more explicit process.
Caffeine and supplemental oxygen effectively suppress periodic breathing with only minor effects during long episodes of apnoea in preterm infants
Authors: Seppä‐Moilanen Maija , Andersson Sture , Rantakari Krista , Mikkola Kaija , Kirjavainen Turkka 
Published: August 2018

AbstractAimWe investigated the characteristics and effects of sleep stage, supplemental oxygen and caffeine on periodic breathing (PB) and apnoea of prematurity (AOP) in preterm infants.MethodsThis 2013‐2015 study recruited 21 preterm infants on neonatal wards in the Helsinki and Uusimaa Hospital District, Finland, at a median corrected gestational age of 35.7 weeks and performed polysomnography at baseline, during supplemental oxygen and during caffeine treatment.ResultsAll infants demonstrated PB, during a median of 11% of sleep time and 85% of PB occurred during non‐rapid eye movement sleep (NREM). Apnoea episodes were brief during PB, but 66% were associated with oxygen desaturation. Supplemental oxygen substantially reduced PB time by 99% and caffeine by 91%. Oxygen desaturation decreased from 38 per hour at baseline to 8.5 with oxygen and 24 with caffeine (all p < 0.001). AOPs decreased from 1.4 per hour at baseline to 0.4 with oxygen (p = 0.03) and 0.3 with caffeine (p = 0.07). Most (84%) apnoea episodes over 15 seconds were mixed episodes during REM sleep.ConclusionPB occurred predominantly during NREM sleep, caused intermittent hypoxia, and was suppressed by supplemental oxygen and caffeine. In contrast, long apnoea episodes representing AOP were only modestly decreased.
Cardiometabolic risk factors differ among adolescents with obesity in three European countries – a cross‐sectional study
Authors: Benestad Beate , Júlíusson Pétur B. , Siegfried Wolfgang , Lekhal Samira , Småstuen Milada Cvancarova , Hertel Jens Kristoffer , Agosti Fiorenza , Marazzi Nicoletta , Hjelmesæth Jøran , Sartorio Alessandro 
Published: August 2018

AbstractAimWe aimed to compare modifiable cardiometabolic risk factors among treatment‐seeking adolescents with obesity in Italy, Germany and Norway.MethodsThis retrospective, registry‐based, cross‐sectional cohort study included 2,327 (59% girls) 12–18 year‐old adolescents with obesity from three tertiary care outpatient clinics in Europe, between 1999 and 2015. The prevalence of cardiometabolic risk factors was compared between clinics, and multivariate logistic regression models including gender, age, waist circumference and body mass index were used to assess the associations between population and cardiometabolic risk.ResultsIn total, 1,396 adolescents (60% girls) from Italy, 654 (58% girls) from Germany and 277 (51% girls) from Norway were included. The mean ± SD age was 15.2 ± 1.6 years, body mass index 38.8 ± 6.5 kg/m2 and body mass index standard deviation score 3.21 ± 0.43. The prevalence of elevated nonhigh‐density lipoprotein‐cholesterol in Norway, Germany and Italy was 60%, 54% and 45%, while the prevalence of high systolic or diastolic blood pressure (≥130 or ≥85 mmHg) were 15%, 46% and 66%, respectively.ConclusionCardiometabolic risk factors among treatment‐seeking adolescents with obesity from Italy, Germany and Norway differed across the populations in this study, which might imply that preventive clinical work should reflect such differences.
Combinations of four or more CpGs methylation present equivalent predictive value for MGMT expression and temozolomide therapeutic prognosis in gliomas
Authors: Chai Rui‐Chao , Zhang Ke‐Nan , Liu Yu‐Qing , Wu Fan , Zhao Zheng , Wang Kuan‐Yu , Jiang Tao , Wang Yong‐Zhi 
Published: August 2018

AbstractAimsThe pyrosequencing (PSQ) has been regarded as the gold standard for MGMT promoter methylation testing in gliomas. However, various CpG combinations are currently used in clinical practice. We aimed to clarify how and how many CpGs combined is robust enough to predict MGMT mRNA expression and therapeutic prognosis of patients.MethodsTotal 223 patients with WHO III/IV gliomas were enrolled from Chinese Glioma Genome Atlas, including two independent cohorts, the eight‐site cohort (with CpGs 75‐82 tested) and the seven‐site cohort (with CpGs 72‐78 tested). Spearman’s correlation and ROC curves were employed to investigate the value of different CpG combinations on predicting MGMT mRNA expression. The ROC curves and Kaplan‐Meier steps were performed to compare the TMZ therapeutic prognostic values of different CpG combinations.ResultsThe methylation level of all individual CpG and CpG combinations for the eleven CpGs (CpGs 72‐82), significantly correlated to MGMT mRNA expression (Spearman, all P < 0.0001), could effectively predict the mRNA expression (AUC, 0.86‐0.91 in the eight‐site cohort, 0.83‐0.90 in the seven‐site cohort). Moreover, the correlation coefficients and the predictive values presented equivalent when four or more CpGs combinedly used (AUC, 0.88‐0.90 in the eight‐site cohort, 0.87‐0.88 in the seven‐site cohort). Finally, similar results were also observed when using selected CpG combinations to predict therapeutic prognosis of patients.ConclusionsFour‐CpG combinations of pyrosequencing are sufficient for evaluating the methylation status of MGMT and predicting therapeutic prognosis in gliomas.
Evaluation of the Cardiac Safety of Long‐Acting Endectocide Moxidectin in a Randomized Concentration‐QT Study
Authors: Kinrade Sally A. , Mason Jay W. , Sanabria Carlos R. , Rayner Craig R. , Bullock Julie M. , Stanworth Stephanie H. , Sullivan Mark T. 
Published: August 2018

Potential effects on cardiac repolarization of single doses of moxidectin, a potent long‐acting macrocyclic lactone endectocide, were assessed in a concentration‐QT (c‐QT; exposure‐response) study. This double‐blind, placebo‐controlled, parallel‐group study in healthy male volunteers (n = 60) randomized subjects to a single oral dose of moxidectin (4 mg, 8 mg, 16 mg, 24 mg, or 36 mg) or matching placebo. Serial plasma samples for pharmacokinetic (PK) analysis and concurrent triplicate electrocardiogram measurements were taken at baseline and 14 prespecified time points over 72 hours, yielding 900 QT interval‐plasma concentration time‐matched pairs. Moxidectin had no statistically significant or clinically relevant impact on QT interval at any dose level. The primary mixed effects model analysis revealed no treatment‐related impact on the Fridericia‐corrected QT interval‐plasma concentration gradient (−0.0077, 90% confidence interval (CI) −0.0255 to +0.0101).
Prediction‐Oriented Model Selection in Partial Least Squares Path Modeling
Authors: Sharma Pratyush Nidhi , Shmueli Galit , Sarstedt Marko , Danks Nicholas , Ray Soumya 
Published: August 2018

ABSTRACTPartial least squares path modeling (PLS‐PM) has become popular in various disciplines to model structural relationships among latent variables measured by manifest variables. To fully benefit from the predictive capabilities of PLS‐PM, researchers must understand the efficacy of predictive metrics used. In this research, we compare the performance of standard PLS‐PM criteria and model selection criteria derived from Information Theory, in terms of selecting the best predictive model among a cohort of competing models. We use Monte Carlo simulation to study this question under various sample sizes, effect sizes, item loadings, and model setups. Specifically, we explore whether, and when, the in‐sample measures such as the model selection criteria can substitute for out‐of‐sample criteria that require a holdout sample. Such a substitution is advantageous when creating a holdout causes considerable loss of statistical and predictive power due to an overall small sample. We find that when the researcher does not have the luxury of a holdout sample, and the goal is selecting correctly specified models with low prediction error, the in‐sample model selection criteria, in particular the Bayesian Information Criterion (BIC) and Geweke–Meese Criterion (GM), are useful substitutes for out‐of‐sample criteria. When a holdout sample is available, the best performing out‐of‐sample criteria include the root mean squared error (RMSE) and mean absolute deviation (MAD). We recommend against using standard the PLS‐PM criteria (R2, AdjustedR2, andQ2), and specifically the out‐of‐sample mean absolute percentage error (MAPE) for prediction‐oriented model selection purposes. Finally, we illustrate the model selection criteria's practical utility using a well‐known corporate reputation model.
“Yet the Root of the Matter is Not in Them”: Reclaiming the Lost Soul of Inspirational Teaching
Authors: Roosevelt Dirck , Garrison Jim 
Published: August 2018

AbstractThis essay by Dirck Roosevelt and Jim Garrison seeks to reclaim the lost soul of teaching by examining distortions wrought upon or threatening it by practice‐based teacher education (PBTE) and like developments. The notion that teaching centers upon mastery of “core” practices understood as routinely skilled performance is inadequate to the almost intractable complexity of teaching. After critiquing PBTE and associated forces, especially the performance assessment edTPA™, Roosevelt and Garrison turn to John Dewey's notion of the teacher as “inspirer and director of soul‐life.” Among other important attributes involved in forming the soul of inspirational teaching, the authors discuss moral perception of the needs, desires, and interests of unique individuals participating in specific situations, and also moral imagination, which allows teachers to see beyond the actual to conceive better possibilities. Roosevelt and Garrison conclude with depictions of two student‐teachers, one troubled by her inability to hear the souls of students and another experiencing the loss of his teaching soul.
Beyond the European void? Reflections on Peter Mair's legacy
Authors: Bickerton Christopher 
Published: August 2018

AbstractPeter Mair was one of the world's leading scholars of party politics. Though he wrote at some length about the European Union, there has been no systematic exploration of the implications of his comparative work on political parties for European integration. His writings on the EU have generally been studied in isolation from his wider oeuvre, with the result that we have missed the important analytical and logical connections between Mair's work on parties and his writings on the EU. This article argues that Mair's path‐breaking middle‐range theoretical and empirical work on the decline of party democracy can form the basis of a radical reappraisal of the project of ‘ever closer union’. The article studies Mair's arguments against the backdrop of more recent empirical evidence and evaluates the normative implications of his work for the future of the European project.