bluuebunny/crossref_metadata_2025_split huggingface dataset:
The changes of standard DXA measurements and TBS depending on outcomes of neurosurgical treatment in patients with Cushing's disease
Authors: Tsoriev Timur T. , Belaya Zhanna E. , Chernova Tatiana O. , Sazonova Natalia I. , Hans Didier , Solodovnikov Alexander G. , Mel'nichenko Galina A. , Dedov Ivan I. 
Published: April 2019

BACKGROUND: Patients with endogenous hypercortisolism have reduced bone mineral density (BMD) and trabecular bone score (TBS) that are the causes of secondary osteoporosis and low-traumatic fractures. It is well known that radical treatment (neurosurgery or radiosurgery) of Cushing’s disease leads to a decline of cortisol levels in all body fluids to normal values. However, it is still uncertain whether bone tissue structure, and particularly its microarchitecture, does recover in remission of the disease.
AIMS: To evaluate an influence of hormone activity (presence or absence of remission) in patients with Cushing's disease on changes of bone structure measurements in accordance with DXA values (TBS, BMD, T- and Z-scores), as well as significance of such changes in 12 and 24 months after neurosurgical treatment.
MATERIALS AND METHODS: In patients with confirmed active Cushing's disease (ACTH-producing pituitary adenoma) (n = 44) and in control group of healthy volunteers (n = 40), BMD in lumbar spine (L1-L4) and simultaneously TBS, in cut-off points before neurosurgical treatment (in both groups) and in 12 and 24 months after it (only in patients), were assessed. We diagnosed presence or absence of disease remission at cut-offs. All measurements were performed using a GE iDXA device (GE Healthcare Lunar, Madison, Wisconsin, USA). The TBS was calculated simultaneously from taken BMD scans, blinded to clinical outcome using TBS iNsight software v2.1 (Medimaps, Merignac, France). The activity of Cushing’s disease was evaluated using late-night salivary cortisol (LNSC, at 23:00). To determine the differences in DXA and TBS values before and after neurosurgical intervention depending on remission occurrence, covariate analysis (ANCOVA) was applied.
RESULTS: There were found significant changes in TBS, BMD and T-score values in 12 months after neurosurgical treatment associated with presence or absence of disease remission (p = 0.039, 0.046 and 0.048, respectively). No differences in Z-score as well as in all measurements in 24 months, that might be associated with remission occurrence, were revealed. The gain in all DXA measurements (including TBS) during 24 months of observation period was statistically significant when analyzing data using Student’s paired t-test. However, the values corresponding to the age references had not been achieved for the specified time interval.
CONCLUSIONS: Patients with Cushing’s disease have lower TBS values. In remission conditions TBS is getting significantly higher. The increase in BMD and TBS occurs during 24 months after achieving remission of Cushing’s disease but doesn’t lead to a full restoration of normal bone mass and microstructure throughout observation period of 24 months.
Adoption factors to digital TV platforms in Turkey
Authors: Yersel Burçin 
Published: April 2019

The main aim of this study is to understand digital TV platform adopters’ media usage and adopting factors by identifying their profile in Turkey. According to this aim, it was tried to find out the demographic characteristics of digital TV broadcasting adopters, media usage level and the factors of adopting. In addition, it was tried to find out demographic variables, media usage frequency differences between adopters of digital TV platform and non-adopters. The result of analysis shows that, while it was found significant differences between adopters’ and non-adopters’ education; was not found significant differences between adopters’ and non-adopters’ age and sex. There is no significant differences between adopters’ and non-adopters’ media uses. According to the results of factor analysis shows that there are 5 reason to adopting digital TV platform.
Kereskedelmi forgalomban használt D-dimer-tesztek vágóértékének harmonizálása
Authors: Török-Nagy Beáta , Vajda Zoltán , Vásárhelyi Barna 
Published: April 2019

Abstract: Introduction: The objective of the D-dimer tests is to exclude venous thromboembolic disorders. The characteristics of various D-dimer tests differ significantly and consequently, their results are difficult to compare. Aim: Our goal was to compare three D-dimer tests, analyse their correlation and harmonise their sensitivity and specificity through the optimisation of cut-off values. Method: At Semmelweis University, the D-dimer level was determined with three different reagents in 158 plasma samples, suspected with venous thromboembolism. INNOVANCE D-Dimer was selected as the referent, and in the case of the two other tests (STA-Liatest D-Di; Dia-D-Dimer), the cut-off values were changed between 0.2–1 µg/ml (fibrinogen-equivalent unit – FEU). The optimal cut-off values were estimated by diagnostic parameters and chi-square test. The correlation of the different tests was calculated by regression analysis. Results: Based on the chi-square statistics, there is no significant difference between STA-Liatest D-Di and INNOVANCE D-Dimer tests using the cut-off values 0.3–1 µg/ml (FEU) (STA-Liatest D-Di). In the case of Dia-D-DIMER, there is a significant difference using 0.2–0.3 µg/ml (FEU) cut-off values, 0.4 µg/ml (FEU) is a border-line value and using 0.5–1 µg/ml (FEU) cut-off values, there is no significant difference. The sensitivity of STA-Liatest D-Di changed between 82.7–100% using 0.2–1 µg/ml (FEU) cut-off values, while the sensitivity of Dia-D-DIMER was 92.3–100%. Their specificities ranged between 50–96.3% and 35.2–87%. The optimal cut-off values were estimated as 0.5–0.6 µg/ml (FEU) for the STA-Liatest D-Di test and 0.7 µg/ml (FEU) for the Dia-D-DIMER test. Conclusion: Each diagnostic laboratory should determine the optimal cut-off value of the D-dimer test in use, considering the examined population of the area. Orv Hetil. 2019; 160(15): 585–592.
Immunomodulating effect of magnetoinfrared laser therapy in children with chronic pyelonephritis
Authors: Illek Ya. Yu. , Vyaznikova M. L. , Leushina N. P. , Mischenko I. Yu. , Ryseva L. L. , Solovyova G. V. , Tarasova E. Yu. , Suetina I. G. , Khlebnikova N. V. 
Published: April 2019

Aim. To determine the influence of magnetoinfrared laser therapy on the status of immunological reactivity in children with chronic pyelonephritis (CP).
Materials and methods. One hundred thirty children aged 8 to12 years, suffering from relapsing course of chronic pyelonephritis, were observed. Group 1 (43 patients) received complex conventional therapy, group 2 (27 patients) – complex treatment, associated with magnetoinfrared laser therapy. The blood lymphocyte population and subpopulation, blood serum immunoglobulin and circulating immune complexes content, phagocytosis indices, blood serum cytokine content was studied in children with chronic pyelonephritis at the active stage of disease, at the partial and full clinicolaboratory remission stages.
Results. The CP patients of group 1, who received complex conventional therapy, demonstrated a full, but not long clinicolaboratpory remission with preservation of marked changes in immunological reactivity parameters. In CP patients of group 2, who experienced complex treatment associated with magnetoinfrared laser therapy courses, there occurred full clinicolaboratory remission and normalization of immunological reactivity indices.
Conclusions. The results of clinical observations and special studies demonstrate high clinical, immunomodulating and antirelapsing effects of complex treatment combined with magnetoinfrared laser therapy in children with chronic pyelonephritis.
Infant mortality at home in Perm Krai. Main causes and prevention
Authors: Kochergina E. A. , Trefilov R. N. , Blyumberg N. V. 
Published: April 2019

Aim. To assess the most frequent causes of infant mortality at home in Perm Krai, to give the main recommendations for its prevention.
Materials and methods. Retrospective study of 165 cases of the death of children under 1 year of age in Perm Krai over the period of 2013-2016 was carried out.
Results. Among the causes of the death of children under 1 year of age at home, the most frequently registered were the following: sudden infant death syndrome (SIDS) – 47.9 %, traumas – 24.8 % and respiratory diseases – 18.8 %. In case of SIDS, the share of premature infants was 16.7 %, more than a half of infants had various signs of morphofunctional immaturity (58.8 %). Mothers’ smoking during pregnancy and after giving birth to a child occurred in 78.6 % of SIDS cases. Half of cases of death at home from traumas in children under age 1 is connected with mechanical asphyxia while sleeping, 33 % – as a result of gastric content aspiration into respiratory tract, 16.7 % – owing to nonobservance of safe conditions of sleep. Infant death in consequence of traumas more often than the other causes of death was accompanied by social risk (75.0 % of cases), regarding SIDS social risk was noted in 66.7 %, acute respiratory diseases – in 50.0 %.
Conclusions. Prevention of the main causes of death at home among infants under 1 year of age consists in a timely detection of prognostic risk and initiation of standard preventing measures.
Gastrointestinal Beriberi as a prodrome of non-alcoholic Wernicke’s encephalopathy: a study of an emerging nutritional deficiency disorder from Kashmir, India
Authors: Shah Irfan Ahmad , Kawoos Yuman , Shah Asif Iqbal , Rabyang Stanzen , Naqash Henna , Mir Mohd Rafi 
Published: April 2019

Background: Gastrointestinal manifestations of thiamine deficiency have not been well described in literature. Authors aimed to study the symptoms of gastrointestinal beriberi in a cohort of patients of non-alcoholic Wernicke’s encephalopathy and review the relevant literature.Methods: In a retrospective analysis, case records of 52 patients diagnosed with non-alcoholic Wernicke’s encephalopathy were analyzed for the nature of gastrointestinal symptoms, their duration, severity and associated findings, investigations and response to treatment. The available literature on gastrointestinal symptoms in thiamine deficiency disorders and gastrointestinal beriberi was reviewed.Results: Gastrointestinal symptoms were found in 46 of the 52 patients. The most common gastrointestinal symptom in our patients was recurrent vomiting in 42 patients. Eight patients had water brash. Ten patients had epigastric pain and 10 patients had anorexia. Based on the nature and severity of symptoms, patients were evaluated for their symptoms using endoscopy, ultrasonography, amylase and lactate levels, and routine laboratory studies and the results were normal in the majority of patients. Gastrointestinal symptoms settled in all the patients after receiving intravenous thiamine. On reviewing the literature multiple studies were found to have reported prominent gastrointestinal symptoms in patients of Wernickes encephalopathy and other thiamine deficiency related disorders. However, the definition of gastrointestinal beriberi is not clearly stated.Conclusions: Gastrointestinal symptoms were prominent prodromal manifestations in our cohort of Wernicke’s encephalopathy and have also been amply reported in literature. Presence of gastrointestinal symptoms in individuals predisposed to thiamine deficiency without alternative explanation should be enough to label a patient as gastrointestinal beriberi. The study highlights the importance of recognizing gastrointestinal beriberi as a distinct syndrome that may precede the development of Wernicke’s encephalopathy.
Pengaruh Dongeng Dalam Peningkatan Emosi Positif Anak Usia Prasekolah
Authors: Trihastuti Annisa , Mulya Yansa Alif , Abdillah Zaid , Hidayati Fina 
Published: April 2019

<p>Penelitian ini bertujuan mengetahui Pengaruh Dongeng dalam perkembangan emosi positif anak usia prasekolah di TK Muslimat NU 21. Metode penelitian yang digunakan adalah metode eksperimen pretest-posttest. Subjek penelitian adalah 40 siswa TK dengan menggunakan dua kelompok variabel yani kontrol dan eksperimen. Terdapat empat emosi positif (Interested, Excited, Inspired, Strong, Active) dalam penelitian ini. Hasil Penelitian menunjukkan terdapat perubahan sebesar 41,2% pada kelompok eksperimen dan 9,34% pada kelompok kontrol. Aspek yang mengalami perbuhan signifikan adalah aspek Interested, Inspired, strong, dan active.</p>
Quels équilibres végétal/animal en France métropolitaine, aux échelles nationale et « petite région agricole » ?
Authors: JOUVEN Magali , PUILLET Laurence , PERROT Christophe , POMEON Thomas , DOMINGUEZ João-Pedro , BONAUDO Thierry , TICHIT Muriel 
Published: April 2019

L’ajustement des activités d’élevage aux ressources localement présentes est un des leviers de la transition écologique, permettant une autonomie des territoires et une moindre consommation d’intrants nécessitant un transport. Le travail présenté ici a été réalisé dans le cadre de l’étude INRA EFESE-écosystèmes agricoles. Il propose une méthode simple basée sur la statistique agricole et plusieurs sources complémentaires pour calculer sur une base annuelle l’équilibre végétal/animal d’un territoire. La capacité d’un territoire à nourrir sa population d’animaux d’élevage (CAPA) est définie comme le rapport entre les ressources végétales disponibles pour l’alimentation animale et la consommation par le cheptel localement présent. Elle peut être calculée en Matière Sèche (MS) ou azotée (MAT), à l’échelle nationale ou des Petites Régions Agricoles (PRA). Les PRA comportant des populations animales trop faibles sont exclues de l’analyse ; de même, l’incertitude sur les données d’effectifs et de consommation des chevaux n’a pas permis de les comptabiliser. Au niveau national, la CAPA globale est bonne (0,98 en MS ; 0,81 en MAT) mais cache un déficit en protéines, avec une CAPA en MAT de 0,42 pour les concentrés, à associer à la dépendance aux tourteaux de soja importés. Au niveau PRA, une typologie fait apparaître cinq groupes distincts en termes d’équilibre végétal/animal. La cartographie de ces groupes permet de distinguer des zones homogènes, et d’autres présentant plusieurs groupes donc des synergies potentielles au niveau supra. Ces résultats originaux mériteront d’être affinés en précisant certains calculs, puis mobilisés pour accompagner la transition écologique des territoires.
Faibles concentrations cellulaires du lait et sensibilité aux mammites des ruminants laitiers
Authors: RAINARD Pascal , FOUCRAS Gilles , BOICHARD Didier , RUPP Rachel 
Published: April 2019

La concentration en cellules du lait (CCS) est un indicateur indirect d’une infection mammaire très utilisé en épidémiologie, mais aussi un prédicteur de la sensibilité aux infections mammaires utile pour la sélection génétique d’animaux plus résistants aux mammites. En raison du rôle de protection immunitaire attribué aux cellules du lait, des réserves sont émises à l’encontre de la sélection d’animaux dont le lait serait pauvre en cellules, ce qui entrainerait une sensibilité accrue aux mammites. Des enquêtes épidémiologiques apparemment contradictoires n’ont pas permis de lever ces réticences. Cependant, une analyse critique des connaissances sur l’immunité mammaire et des études récentes réalisées sur des animaux issus d’une sélection divergente sur les valeurs génétiques du caractère « Cellules » permettent de répondre à la question « Faut-il éviter de sélectionner des animaux laitiers dont les CCS sont très faibles ? ». Il apparait clairement qu’en l’absence d’infection, les valeurs de CCS sont physiologiquement très faibles et ne sont pas modifiées par la sélection, qui ne réduit pas non plus la capacité de la mamelle à se défendre contre les infections.
A REPERCUSSÃO GERAL E TRATADOS DE DIREITOS HUMANOS NO BRASIL
Authors: Gomes Eduardo Biacchi , Lameira Daniella Pinheiro 
Published: April 2019

<p>A Constituição de 1988 consolidou no ordenamento jurídico brasileiro a observância dos direitos fundamentais, principalmente através do artigo 5º e o seu § 2º, que deve ser entendido como uma cláusula aberta para a incorporação dos tratados de direitos humanos ratificados pela República Federativa do Brasil. Passados quase trinta anos desde o advento da Constituição de 1988, os jurisdicionados ainda encontram certos óbices na tutela e efetivação dos direitos fundamentais, principalmente quando pautados em tratados. Isso acarreta em um grande número de ações que tramitam nas Cortes e demoram para ter uma solução final. O presente artigo tem como premissa a análise do instituto da Repercussão Geral como mecanismo de efetivação dos Direitos Humanos, principalmente aqueles decorrentes dos Tratados ratificados pela República Federativa do Brasil. A pesquisa é doutrinária e jurisprudencial e utilizou-se a metodologia dedutiva e indutiva.</p><p> </p>
Three-Phase Sandstone Acidizing: Quantification and Analysis of Evolved CO2 in the Presence of Oil and Water
Authors: Muhemmed Sajjaat , Kumar Harish , Nasr-El-Din Hisham 
Published: April 2019

Abstract
The proposed paper presents a detailed study on evolving CO2 due to calcite mineral dissolution, and its ensuing activity during the matrix acidizing of sanstone reservoirs. Coreflood experiments were conducted in acidizing, and interpreted via simulation studies using a three-phase, two scale continuum model. Sensitivity studies were then performed on the calibrated simulation model. Acid injection was performed on 6 in.-length, 1.5 in.-diameter Bandera Brown sandstone cores of variable calcite content, using 15 wt% HCl single-phase coreflood experiments at high back pressures were conducted to calibrate and initially test the three-phase, two-scale continuum model. Experimentally measured rock-heterogeneity via computed tomography (CT) scans, relative-permeability and capillary pressures, oil-water interfacial tension and contact-angle parameters were inputs for three-phase, two-scale model-based history matching and sensitivity studies. The three-phase, two-scale continuum model was able to match all performed coreflood experiments with a good level of accuracy. The acid-calcite chemical reaction parameters were fixed in all cases to ensure consistency in analysis. Oil production was observed, with an average of 40% recovery of the residual oil in place at CO2 miscible pressures. CO2 miscibility in oil enhances swelling with time, which was seen as the main mechanism for oil production. A direct symmetry was observed between the oil recovery and average CO2 moles in oil. The recovery curve flattened once surrounding oil reached its full-saturation level with CO2. Reduction in oil-water interfacial-tension increased the recovery factor only by a slight margin, owing to dependency on evolved CO2 volume. Immiscible CO2 conditions yielded no residual oil recovery. The successful application of the three-phase, two-scale continuum model approach sets a new bar in the area of sandstone acidizing. The acid breakthrough criterion has been revised toward application in a three-phase environment. The potential of CO2, a by-product of acidizing, towards its contribution in swelling oil in the presence of a three-phase environment, and towards possible oil recovery in the event of flowing back a well.
A Novel Image Encryption Algorithm Using Multiple Encryption Techniques for Mobile Devices
Authors: Bhat Showkat Ahmad , Singh Amandeep 
Published: April 2019

Background & Objective:
Digital multimedia exchange between different mobile communication
devices has increased rapidly with the invention of the high-speed data services like
LTE-A, LTE, and WiMAX. However, there are always certain security risks associated with the use
of wireless communication technologies.

Methods:
To protect the digital images against cryptographic attacks different image encryption algorithms
are being employed in the wireless communication networks. These algorithms use comparatively
less key spaces and accordingly offer inadequate security. The proposed algorithm described
in this paper based on Rubik’s cube principle because of its high confusion and diffusion
properties, Arnold function having effective scrambling power, blocking cipher with block encryption
and permutation powers. The main strength of the proposed algorithm lies in the large key spaces
and the combination of different high power encryption techniques at each stage of algorithm. The
different operations employed on the image are with four security keys of different key spaces at
multiple stages of the algorithm.

Results & Conclusion:
Finally, the effectiveness and the security analysis results shows that the proposed
image encryption algorithm attains high encryption and security capabilities along with high
resistance against cryptanalytic attacks, differential attacks and statistical attacks.
An Efficient Fitness Function for Clustering of Wireless Sensor Networks
Authors: Hoseinpour Atiieh , Lahijani Mojtaba Jafari , Hosseinpour Mohammad , Kazemitabar Javad 
Published: April 2019

Background & Objective:
A sensor network is composed of a large number of sensor nodes
that are deployed to perform measurement and/or command and control in a field. Sensor nodes are battery
powered devices and replacement or recharging of their batteries may not be feasible. One of the
major challenges with sensory wireless networks is excessive energy consumption in nodes. Clustering
is one of the methods that has been offered for resolving this issue. In this paper, we pursue evolutionary
clustering and propose a new fitness function that har-nesses multiple propagation indices.

Methods:
In this paper we develop an efficient fitness function by first selecting the best clusters,
and then selecting the best attribution of cluster to clusters. The distance between the nodes and relevant
cluster heads was used for the mathematical modelling necessary. In the end we develop the fitness
function equation by using normalization of the raw data.

Results:
Simulation results show improvement compared to previous fitness functions in clustering
of the wireless sensor networks.
The Repulsive Force Spectrum of Magnetorheological Fluids Based Tactile Devices Applicable to Robot Surgery
Authors: Park Yu-Jin , Yoon Ji-Young , Lee Ye-Ho , Choi Seung-Bok 
Published: April 2019

Objective:
This paper presents controllable force ranges of tactile devices made of smart
Magnetorheological Fluids (MRF) and porous sponges (MR sponges in short).

Methods:
In order to identify the wide controllable range of the field-dependent repulsive force, three
MR sponge samples with three different MR fluids are fabricated using polyurethane foam and cling
film. Then, the repulsive forces of the samples are measured using the motor-driven experimental
apparatus and the results are presented with minimum and maximum values of the repulsive forces.
On the other hand, in order to investigate the feasibility of the proposed tactile device for application
to Robot-assisted Minimally Invasive Surgery (RMIS), pig’s organs such as liver, lung and heart,
whose viscoelastic properties are very similar to those of human tissues, are tested under same conditions.

Results:
It is shown that the range of the repulsive spectrum of the pig’s organs can be achieved using
the proposed samples by controlling the magnetic field intensity to be applied to MRF domain.