bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possible molecular mechanisms of glucose‐lowering activities of Momordica charantia (karela) in diabetes
Authors: Pahlavani Naseh , Roudi Fatemeh , Zakerian Mohsen , Ferns Gordon A , Navashenaq Jamshid Gholizadeh , Mashkouri Amir , Ghayour‐Mobarhan Majid , Rahimi Hamidreza 
Published: February 2019

AbstractDiabetes mellitus is a highly prevalent metabolic disorder which is characterized by impaired glucose tolerance, with a relative or absolute insulin deficiency and profound changes in the metabolism of macronutrients. Traditional and complementary medicine is therapeutic strategies that have both been applied to improving glycemic control. Momordica charantia is one of the plant‐based, folk medicines that used for improving glycemic control. We aimed to review, the effects of M. charantia on blood glucose with a clarification of the molecular pathways involved. Of the compounds derived from the plants, the insulin‐like peptide, charantin, and the alkaloid vicine, have been reported to have hypoglycemic effects. Different mechanisms contribute to the antidiabetic activities of M. charantia, these include increasing pancreatic insulin secretion, decreasing insulin resistance and increasing peripheral and skeletal muscle cell glucose utilization, inhibition of intestinal glucose absorption and suppressing of key enzymes in the gluconeogenic pathways.
Racial discrimination, John Henryism coping, and behavioral health conditions among predominantly poor, urban African Americans: Implications for community‐level opioid problems and mental health services
Authors: Jones Shawn C. T. , Brooks Jennifer H. , Milam Adam J. , Barajas Clara B. , LaVeist Thomas A. , Kane Erika , Furr‐Holden C. Debra M. 
Published: February 2019

AbstractThe current study examined the relationship between John Henryism Active Coping (JHAC), experiences of racial discrimination, and behavioral health outcomes in a community sample of 319 Black adults. Assessments included primary health care screenings as well as self‐reported survey questions to assess JHAC, experiences of discrimination, and self‐reported behavioral health. Logistic regression models, adjusted for control variables, found a significant relationship between JHAC and having an opioid problem (odds ratio [OR] = 0.95, p = 0.003) and needing mental health services (OR = 0.95, p < 0.001), such that higher levels of coping were associated with lower odds of reporting an opioid problem and needing mental health services. Notably, racial discrimination was not significantly independently associated with behavioral health. Implications for interventions and community programming are discussed.
Cervical cancer in pregnancy: Analysis of the literature and innovative approaches
Authors: Perrone Anna Myriam , Bovicelli Alessandro , D'Andrilli Giuseppina , Borghese Giulia , Giordano Antonio , De Iaco Pierandrea 
Published: February 2019

AbstractCervical cancer is one of the most common gynecological malignancies diagnosed during pregnancy although, fortunately, it is a rare event. In majority of cases, the management of cervical cancer in pregnant women is not different from nonpregnant women and prognosis seems not compromised by pregnancy. The association between cancer and pregnancy appears to be a significant challenge for women and specialists and the decisions about therapy must be individualized and taken by a multidisciplinary team. This review is focused on cervical cancer in pregnancy. The aim is to discuss the diagnosis, potential biomarkers and molecular aspects, therapeutic approaches, and prognosis from intraepithelial cervical neoplasia to invasive cervical cancer (early and advanced stages) in different gestational ages. We provide an overview of the current literature regarding the treatment strategies of concurrent pregnancy and cervical cancer cases and we propose some clinical advices to help clinicians to manage this condition. A mention about the effects of the conservative therapy (as conization) on fertility, the human papillomavirus vaccine in pregnant women and our center's experience with obstetrical and oncological outcomes are reported.
Mesenchymal stem cell basic research and applications in dog medicine
Authors: Gugjoo Mudasir Bashir , Amarpal Amarpal , Sharma Gutulla Taru 
Published: February 2019

AbstractThe stem cells, owing to their special characteristics like self‐renewal, multiplication, homing, immunomodulation, anti‐inflammatory, and dedifferentiation are considered to carry an “all‐in‐one‐solution” for diverse clinical problems. However, the limited understanding of cellular physiology currently limits their definitive therapeutic use. Among various stem cell types, currently mesenchymal stem cells are extensively studied for dog clinical applications owing to their readily available sources, easy harvesting, and ability to differentiate both into mesodermal, as well as extramesodermal tissues. The isolated, culture expanded, and characterized cells have been applied both at preclinical as well as clinical settings in dogs with variable but mostly positive results. The results, though positive, are currently inconclusive and demands further intensive research on the properties and their dependence on the applications. Further, numerous clinical conditions of dog resemble to that of human counterparts and thus, if proved rewarding in the former may act as basis of therapy for the latter. The current review throws some light on dog mesenchymal stem cell properties and their potential therapeutic applications.
Generation of insulin‐producing hepatocyte‐like cells from human Wharton's jelly mesenchymal stem cells as an alternative source of islet cells
Authors: Beikmohammadi Leila , Bandehpour Mojgan , Hashemi Seyed Mahmoud , Kazemi Bahram 
Published: February 2019

AbstractIslet cell transplantation, as a treatment of type 1 diabetes, has a lot of complexity such as allograft rejections and an insufficient number of donors. The liver can be used as a replacement for endogenous insulin production. Hepatocytes can inherently respond to glucose levels and secrete proteins. Utilization of mesenchymal stem cells for curing diabetes represents a major focus of recent investigations. As a new choice for transplantation, we have proposed glucose‐regulated insulin‐producing hepatocyte‐like cells, which produce insulin dependent on glucose levels. We have transfected human Wharton's jelly mesenchymal stem cells with the special construct, which included homology arms and glucose‐responsive elements upstream of the minimum liver‐type pyruvate kinase promoter‐directed insulin gene. Then, we have differentiated these transfected cells to hepatocyte‐like cells by using serial exposure of different inducing material and exogenous growth factors. Immunofluorescence analyses have demonstrated the expression of albumin, cytokeratin‐18, Hep‐Par1, α‐fetoprotein, and insulin. The expression of hepatocyte marker genes in the differentiated cells was confirmed by reverse‐transcription polymerase chain reaction. Interestingly, flow cytometry results showed that approximately 60% of the insulin‐producing hepatocyte‐like cells were simultaneously cytochrome P450 3A4 (CYP3A4) and insulin positive. CYP3A4 is a significant enzyme found in mature liver tissue. This confirmed that the differentiation and the transfection procedures were done correctly. They were functionally active by releasing insulin in response to elevated glucose concentrations in vitro. These applicable cells could be used in the liver for cell therapy of diabetes.
New therapy with XLQ® to suppress chronic prostatitis through its anti‐inflammatory and antioxidative activities
Authors: Yang Feiya , Meng Lingquan , Han Panpan , Chen Dexi , Wang Mingshuai , Jiang Yongguang , Wu Yanqiao , Wu Yiling , Xing Nianzeng 
Published: February 2019

AbstractChronic prostatitis is a common urological disease. The etiology of this disease and effective therapy for its treatment are yet to be elucidated. We investigated the functions of XLQ® in chronic nonbacterial prostatitis using a complete Freund's adjuvant‐induced rat model. Prostates and blood samples were collected for further evaluation after oral gavage with XLQ
® or a vehicle for 4 weeks. The results showed that XLQ
® significantly decreased the prostate index, ameliorated the histopathologic changes, and reduced CD3+ and CD45+ cell infiltration in the prostate stroma. Further study showed that XLQ
® suppressed the expression of proinflammatory cytokines, such as interleukin (IL)‐1β, IL‐2, IL‐6, IL‐17A, monocyte chemoattractant protein‐1, and tumor necrosis factor‐α. XLQ
® showed a strong antioxidant capacity by enhancing the activities of antioxidative enzymes (e.g., total superoxide dismutase, catalase, and glutathione peroxidase) and decreasing the level of lipid peroxidation products (malondialdehyde). Moreover, XLQ
® can suppress the activation of nuclear factor‐κB and P38‐mitogen‐activated protein kinase signaling pathways. In summary, XLQ
® has affirmative effects on chronic prostatitis, which could be attributed to its anti‐inflammatory and antioxidative capacities. On the basis of these results, XLQ
® can be developed as an effective and safe therapy for chronic prostatitis.
Effects of human umbilical cord mesenchymal stem cells on co‐cultured ovarian carcinoma cells
Authors: Li Xiufeng , Li Zongming 
Published: February 2019

AbstractOvarian carcinoma is mainly treated by surgery aided by chemotherapy. If supplemented by stem cells treatment, its recurrence rate and mortality rate will be decreased. This is a new therapy. In this study, ovarian cancer cells were cultured together with umbilical cord mesenchymal stem cells (UCMSCs), and the interactions between them were observed. The results showed that the survival rates of UCMSCs increased to 83.8 ± 2.2% from 56.5 ± 5.5%, and the survival rates of ovarian cancer cells decreased to 16.2 ± 2.2% from 43.5 ± 5.5% with the progression of the cultural time from 24 to 96 hr. There was a significant difference between them (p < .05). It revealed that UCMSCs could inhibit the proliferation of ovarian cancer cells.
CRTAM+ NK cells endowed with suppressor properties arise in leukemic bone marrow
Authors: Ramírez-Ramírez Dalia , Padilla-Castañeda Sandra , Galán-Enríquez Carlos Samuel , Vadillo Eduardo , Prieto-Chávez Jessica Lakshmi , Jiménez-Hernández Elva , Vilchis-Ordóñez Armando , Sandoval Antonio , Balandrán Juan Carlos , Pérez-Tapia Sonia Mayra , Ortiz-Navarrete Vianney , Pelayo Rosana 
Published: February 2019

Abstract
Due to their increasing rates of morbidity and mortality, childhood malignancies are considered a global health priority, with acute lymphoblastic leukemias (ALLs) showing the highest incidence worldwide. Control of malignant clone emergence and the subsequent normal-leukemic hematopoietic cell out-competition require antitumor monitoring mechanisms. Investigation of cancer surveillance innate cells may be critical to understand the mechanisms contributing in either disease progression or relapse, and to promote displacement of leukemic hematopoiesis by the normal counterpart. We report here that NK cell production is less and low hematopoietic progenitor numbers contribute to this defect. By investigating the expression of the activation molecule class I restricted T-cell associated molecule (CRTAM) along the hematopoietic lineage differentiation pathway, we have identified lymphoid precursor populations coexpressing CD34, CD56/CD3/CD19, and CRTAM as the earliest developmental stage where activation may take place in specialized niches that display the ligand nectin-like-2. Of note, bone marrow (BM) from patients with ALL revealed high contents of preactivated CD56high NK cells expressing CRTAM and endowed with an exhaustion-like phenotype and the functional capability of producing IL-10 and TGF-β in vitro. Our findings suggest, for the first time, that the tumor microenvironment in ALL directly contribute to exhaustion of NK cell functions by the CRTAM/Necl-2 interaction, and that the potential regulatory role of exhausted-like NK cells may favor malignant progression at the expense of anti-tumor responses. Phenotypic and functional identity of this unique suppressor-like NK cell population within the leukemic BM would be of special interest for the pathobiology of ALL and development of targeting strategies.
Siphonariid development: Quintessential euthyneuran larva with a mantle fold innovation (Gastropoda; Panpulmonata)
Authors: Page Louise R. , Hildebrand Ilsa M. , Kempf Stephen C. 
Published: February 2019

AbstractRecent phylogenetic revisions of euthyneuran gastropods (“opisthobranchs” and “pulmonates”) suggest that clades with a planktotrophic larva, the ancestral life history for euthyneurans, are more widely distributed along the trunk of the euthyneuran tree than previously realized. There is some indication that the planktotrophic larva of euthyneurans has distinctive features, but information to date has come mainly from traditional “opisthobranch” groups. Much less is known about planktotrophic “pulmonate” larvae. If planktotrophic larvae of “pulmonates” share unique traits with those of “opisthobranchs,” then a distinctive euthyneuran larval‐type has been the developmental starting template for a spectacular amount of evolved morphological and ecological disparity among adult euthyneurans. We studied development of a siphonariid by preparing sections of larval and postmetamorphic stages for histological and ultrastructural analysis, together with 3D reconstructions and data from immunolabeling of the larval apical sensory organ. We also sought a developmental explanation for the unusual arrangement of shell‐attached, dorso‐ventral muscles relative to the mantle cavity of adult siphonariids. Adult siphonariids (“false limpets”) have a patelliform shell but their C‐shaped shell muscle partially embraces a central mantle cavity, which is different from the arrangement of these components in patellogastropods (“true limpets”). It is not obvious how shell muscles extending into the foot become placed anterior to the mantle cavity during siphonariid development from a veliger larva. We found that planktotrophic larvae of Siphonaria denticulata are extremely similar to previously described, planktotrophic “opisthobranch” larvae. To emphasize this point, we update a list of distinctive characteristics of planktotrophic euthyneuran larvae, which can anchor future studies on the impressive evolvability of this larval‐type. We also describe how premetamorphic and postmetamorphic morphogenesis of larval mantle fold tissue creates the unusual arrangement of shell‐muscles and mantle cavity in siphonariids. This result adds to the known postmetamorphic evolutionary innovations involving mantle fold tissue among euthyneurans.
Abaloparatide, a PTH receptor agonist with homology to PTHrP, enhances callus bridging and biomechanical properties in rats with femoral fracture
Authors: Lanske Beate , Chandler Heidi , Pierce Allen , Brown Jeffery , Ominsky Michael , Kostenuik Paul , Hattersley Gary 
Published: February 2019

ABSTRACTFractures typically heal via endochondral and intramembranous bone formation, which together form a callus that achieves union and biomechanical recovery. PTHrP, a PTH receptor agonist, plays an important physiological role in fracture healing as an endogenous stimulator of endochondral and intramembranous bone formation. Abaloparatide, a novel systemically‐administered osteoanabolic PTH receptor agonist that reduces fracture risk in women with postmenopausal osteoporosis, has 76% homology to PTHrP, suggesting it may have potential to improve fracture healing. To test this hypothesis, ninety‐six 12‐week‐old male rats underwent unilateral internally‐stabilized closed mid‐diaphyseal femoral fractures and were treated starting the next day with daily s.c. saline (Vehicle) or abaloparatide at 5 or 20 µg/kg/d for 4 or 6 weeks (16 rats/group/time point). Histomorphometry and histology analyses indicated that fracture calluses from the abaloparatide groups exhibited significantly greater total area, higher fluorescence scores indicating more newly‐formed bone, and higher fracture bridging scores versus Vehicle controls. Callus bridging score best correlated with callus cartilage score (r = 0.64) and fluorescence score (r = 0.67) at week 4, and callus area correlated with cartilage score (r = 0.60) and fluorescence score (r = 0.89) at Week 6. By micro‐CT, calluses from one or both abaloparatide groups had greater bone volume, bone volume fraction, bone mineral content, bone mineral density, and cross‐sectional area at both time points versus Vehicle controls. Destructive bending tests indicated greater callus maximum load and stiffness in one or both abaloparatide groups at both time points versus Vehicle controls. These results provide preliminary preclinical evidence for improved fracture healing with systemically‐administered abaloparatide. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
Kinetic study on the reaction of lauric acid with ethanol catalyzed by deep eutectic solvent based on cetyl trimethyl ammonium bromide
Authors: Li Kun , Chen Xiao , Xue Weilan , Zeng Zuoxiang , Jiang Shan 
Published: February 2019

AbstractIn this work, a novel type of deep eutectic solvents (DES: CTAB–DES) based on cetyl trimethyl ammonium bromide (CTAB) was successfully synthesized by mixing CTAB with p‐toluenesulfonic acid monohydrate and applied as catalysts for the esterification reaction of ethanol and lauric acid. The kinetics of the reaction of ethanol and lauric acid catalyzed by CTAB–DES was investigated in the temperature range of 328.15–348.15 K. The influence of different parameters including agitation speed, temperature, catalyst loading, and the lauric acid to ethanol molar ratio on the conversion of lauric acid was discussed. The kinetic experimental data obtained were correlated by the pseudo‐homogeneous model, and the results show that it can predict the reaction process well. Moreover, CTAB–DES can be reused six times without any significant decrease in catalytic activity.
Chemical and enzymatic stability of the oleanoyl oxime ibuprofenate
Authors: Muszalska Izabela , Lesniewska‐Kowiel Monika A. , Becla Katarzyna , Duda Wojciech , Pawełczyk Anna , Sowa‐Kasprzak Katarzyna , Olender Dorota 
Published: February 2019

AbstractThe stress tests as well as photostability analysis in solutions and the solid phase of the oleanoyl oxime ibuprofenate (Ibu‐OxOA) were determined according the International Conference on Harmonization guidelines. For observation of the degradation of tested compounds, the reversed phase high‐performance liquid chromatography (RP‐HPLC) method was used. The study included the effect of temperature, water, H+ and OH− ions, hydrogen peroxide, and light (6.0 × 106, 1.2 × 106 lux·h) on the stability of the tested hybrid. Studies have shown that these compounds are not stable in a neutral, acidic, or oxidizing medium; very unstable in an alkaline medium; and photostable in a solution and photostable in the solid phase. Studies on the enzymatic stability of the tested hybrid showed that it is not susceptible to degradation in the presence of plasma enzymes as well as in the presence of esterase (37°C, 80% human plasma). The degradation of this compound was observed in the presence of lipase (from Candida antarctica), and the linear dependence of the determined kinetic parameters of the reaction on the enzyme activity was demonstrated.
A novel differential bandpass filter with ultra‐wide band common‐mode suppression
Authors: Zhang Xiao‐Yu , Wang Yang , Lee Jong‐Chul 
Published: February 2019

AbstractA compact differential filter with ultra‐wide band common‐mode (CM) suppression is proposed. Ultra‐wide band property is achieved by the frequency‐selecting coupling structure (FSCS), which generates three transmission zeros in the passband of differential‐mode (DM) as well as in the stopband of CM. Moreover, the position of the transmission zeros, the CM insertion loss and the DM return loss can be customized by designing the parameters of the FSCS. To verify the concept, a filter has been designed, simulated and measured. The proposed filter shows the center frequency of 2.45 GHz with a DM 3 dB fractional bandwidth of 51% and a CM 20 dB fractional bandwidth of 108.6%.
The prevalence and diagnostic classification of mixed features in patients with major depressive episodes: A multicenter study based on the DSM‐5
Authors: Shim In Hee , Lee Jonghun , Kim Moon‐Doo , Jung Young‐Eun , Min Kyung Joon , Kwon Young‐Joon , Kim Ji Sun , Lee Kwanghun , Woo Young Sup , Nam Beomwoo , Seo Jeong Seok , Lee Jung Goo , Jon Duk‐In , Sohn Inki , Park Sung‐Yong , Yoon Bo‐Hyun , Bahk Won‐Myong 
Published: February 2019

AbstractObjectivesThe purpose of this study was to evaluate the prevalence of mixed features using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5) and to examine how patients with mixed states would be classified using the DSM‐5.MethodsIn total, 12 hospitals participated in this study, and data on the demographic characteristics and clinical diagnoses of patients treated between October 2013 and September 2016 were obtained. We reviewed the data for opposite‐polarity symptoms according to the DSM‐5 criteria and the research‐based diagnostic criteria.ResultsOf the 859 patients included in the final analysis, the prevalence of mixed features in patients with major depressive episodes based on the DSM‐5 remained low. Patients with major depressive disorder were more likely to be classified as experiencing anxious distress and/or a cluster‐B personality disorder in mixed state patients not diagnosed with DSM‐5 mixed features, whereas more mixed state patients with bipolar disorder were diagnosed with mixed features using the DSM‐5.ConclusionsThe prevalence of mixed features did not increase significantly when the DSM‐5 was used, and patients with mixed states were more likely to be classified as having anxious distress and/or a cluster‐B personality disorder in addition to mixed features.
Low‐field NMR for quality control on oils
Authors: Rudszuck Thomas , Förster Eva , Nirschl Hermann , Guthausen Gisela 
Published: February 2019

AbstractOil is a prominent, but multifaceted material class with a wide variety of applications. Technical oils, crude oils as well as edibles are main subclasses. In this review, the question is addressed how low‐field NMR can contribute in oil characterization as an analytical tool, mainly with respect to quality control. Prerequisite in the development of a quality control application, however, is a detailed understanding of the oils and of the measurement. Low‐field NMR is known as a rich methodical toolbox that was and is explored and further developed to address questions about oils, their quality, and usability as raw materials, during production and formulation as well as in use.
Energy‐efficient scheduling for sustainable manufacturing systems with renewable energy resources
Authors: Cui Weiwei , Li Lin , Lu Zhiqiang 
Published: February 2019

AbstractEnvironmentally friendly energy resources open a new opportunity to tackle the problem of energy security and climate change arising from wide use of fossil fuels. This paper focuses on optimizing the allocation of the energy generated by the renewable energy system to minimize the total electricity cost for sustainable manufacturing systems under time‐of‐use tariff by clipping the peak demand. A rolling horizon approach is adopted to handle the uncertainty caused by the weather change. A nonlinear mathematical programming model is established for each decision epoch based on the predicted energy generation and the probability distribution of power demand in the manufacturing plant. The objective function of the model is shown to be convex, Lipchitz‐continuous, and subdifferentiable. A generalized benders decomposition method based on the primal‐dual subgradient descent algorithm is proposed to solve the model. A series of numerical experiments is conducted to show the effectiveness of the solution approach and the significant benefits of using the renewable energy resources.