bluuebunny/crossref_metadata_2025_split huggingface dataset:
Objective Assessment of Beat Quality in Transcranial Doppler Measurement of Blood Flow Velocity in Cerebral Arteries
Authors: Jalaleddini Kian , Canac Nicolas , Thorpe Samuel G. , Delay Benjamin , Dorn Amber Y. , Scalzo Fabien , Thibeault Corey M. , Wilk Seth , Hamilton Robert B. 
Published: February 2019

AbstractObjectiveTranscranial Doppler (TCD) ultrasonography measures pulsatile cerebral blood flow velocity in the arteries and veins of the head and neck. Similar to other real-time measurement modalities, especially in healthcare, the identification of high quality signals is essential for clinical interpretation. Our goal is to identify poor quality beats and remove them prior to further analysis of the TCD signal.MethodsWe selected objective features for this purpose including Euclidean distance between individual and average beat waveform, cross-correlation between individual and average beat waveform, ratio of the high frequency power to the total beat power, beat length, and variance of the diastolic portion of the beat waveform. We developed an iterative outlier detection algorithm to identify and remove the beats that are different from others in a recording. Finally, we tested the algorithm on a dataset consisting of more than 16 hours of TCD data recorded from 48 stroke and 35 in-hospital control subjects.ResultsWe assessed the performance of the algorithm in estimating clinically important TCD parameters by comparison to those identified from beats hand-annotated by an expert. The results show that there is strong correlation between the two that delineates the algorithm has successfully recovered clinically important features. We obtained significant improvement in estimating the TCD parameters using the algorithm accepted beats compared to using all beats (r>0.78, p<0.01).SignificanceOur algorithm provides a valuable tool to the clinicians for automated detection of the reliable portion of the data. Moreover, it can be used as a pre-processing tool to improve the data quality for machine learning algorithms for automated diagnosis of pathologic beat waveform.
Intra- and Inter-Specific Investigations of Skeletal DNA Methylation and Femur Morphology in Primates
Authors: Housman Genevieve , Quillen Ellen E. , Stone Anne C. 
Published: February 2019

AbstractObjectivesEpigenetic mechanisms influence the development and maintenance of complex phenotypes and may also contribute to the evolution of species-specific phenotypes. With respect to skeletal traits, little is known about the gene regulation underlying these hard tissues or how tissue-specific patterns are associated with bone morphology or vary among species. To begin exploring these topics, this study evaluates one epigenetic mechanism, DNA methylation, in skeletal tissues from five nonhuman primate species which display anatomical and locomotor differences representative of their phylogenetic groups.Materials and MethodsFirst, we test whether intra-specific variation in skeletal DNA methylation is associated with intra-specific variation in femur morphology. Second, we identify inter-specific differences in DNA methylation and assess whether these lineage-specific patterns may have contributed to species-specific morphologies. Specifically, we use the Illumina Infinium MethylationEPIC BeadChip to identify DNA methylation patterns in femur trabecular bone from baboons (n=28), macaques (n=10), vervets (n=10), chimpanzees (n=4), and marmosets (n=6).ResultsSignificant differentially methylated positions (DMPs) were associated with a subset of morphological variants, but these likely have small biological effects and may be confounded by other variables associated with morphological variation. Conversely, several species-specific DMPs were identified, and these are found in genes enriched for functions associated with complex skeletal traits.DiscussionOverall, these findings reveal that while intra-specific epigenetic variation is not readily associated with skeletal morphology differences, some inter-specific epigenetic differences in skeletal tissues exist and may contribute to evolutionarily distinct phenotypes. This work forms a foundation for future explorations of gene regulation and skeletal trait evolution in primates.
The carboxyl-terminal sequence of Bim enables Bax activation and killing of unprimed cells
Authors: Chi Xiaoke , Nguyen Dang , Pemberton James M , Osterlund Elizabeth J , Liu Qian , Brahmbhatt Hetal , Zhang Zhi , Lin Jialing , Leber Brian , Andrews David W. 
Published: February 2019

AbstractThe Bcl-2 family BH3 protein Bim promotes apoptosis at mitochondria by activating the pore forming proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and Mcl-1. Bim binds to these proteins via its BH3 domain and to the mitochondrial membrane by a carboxyl-terminal sequence (CTS). In cells killed by Bim, the expression of a Bim mutant in which the CTS was deleted (BimL-dCTS) triggered variable amounts of apoptosis that correlated with inhibition of anti-apoptotic proteins being sufficient to permeabilize mitochondria isolated from the same cells. Detailed analysis of the molecular mechanism demonstrated that BimL-dCTS inhibited Bcl-XL but did not activate Bax. Our examination of additional point mutants unexpectedly revealed that the CTS of Bim is required for physiological concentrations of Bim to activate Bax and that different residues in the CTS enable Bax activation and binding to membranes.
Conditional Prediction of RNA Secondary Structure Using NMR Chemical Shifts
Authors: Zhang Kexin , Frank Aaron T. 
Published: February 2019

ABSTRACTInspired by methods that utilize chemical-mapping data to guide secondary structure prediction, we sought to develop a framework for using assigned chemical shift data to guide RNA secondary structure prediction. We first used machine learning to develop classifiers which predict the base-pairing status of individual residues in an RNA based on their assigned chemical shifts. Then, we used these base-pairing status predictions as restraints to guide RNA folding algorithms. Our results showed that we could recover the correct secondary folds for nearly all of the 108 RNAs in our dataset with remarkable accuracy. Finally, we assessed whether we could conditionally predict the structure of the model RNA, microRNA-20b (miR-20b), by folding it using folding restraints derived from chemical shifts associated with two distinct conformational states, one a free (apo) state and the other a protein-bound (holo) state. For this test, we found that by using folding restraints derived from chemical shifts, we could recover the two distinct structures of the miR-20b, confirming our ability to conditionally predict its secondary structure. A command-line tool for Chemical Shifts to Base-Pairing Status (CS2BPS) predictions in RNA has been incorporated into our CS2Structure Git repository and can be accessed via: https://github.com/atfrank/CS2Structure.
Single molecule real time (SMRT) full length RNA-sequencing reveals novel and distinct mRNA isoforms in human bone marrow cell subpopulations
Authors: Mays Anne Deslattes , Schmidt Marcel O. , Graham Garrett T. , Tseng Elizabeth , Baybayan Primo , Sebra Robert , Sanda Miloslav , Mazarati Jean-Baptiste , Riegel Anna T. , Wellstein Anton 
Published: February 2019

AbstractHematopoietic cells are continuously replenished from progenitor cells that reside in the bone marrow. To evaluate molecular changes during this process, we analyzed the transcriptomes of freshly harvested human bone marrow progenitor (lineage-negative) and differentiated (lineage-positive) cells by single molecule, real time (SMRT) full length RNA sequencing. This analysis revealed a ∼5-fold higher number of transcript isoforms than previously detected and showed a distinct composition of individual transcript isoforms characteristic for bone marrow subpopulations. A detailed analysis of mRNA isoforms transcribed from the ANXA1 and EEF1A1 loci confirmed their distinct composition. The expression of proteins predicted from the transcriptome analysis was validated by mass spectrometry and validated previously unknown protein isoforms predicted e.g. for EEF1A1. These protein isoforms distinguished the lineage negative cell population from the lineage positive cell population. Finally, transcript isoforms expressed from paralogous gene loci (e.g. CFD, GATA2, HLA-A, B & C) also distinguished cell subpopulations but were only detectable by full length RNA sequencing. Thus, qualitatively distinct transcript isoforms from individual genomic loci separate bone marrow cell subpopulations indicating complex transcriptional regulation and protein isoform generation during hematopoiesis.
Designing a hybrid cloud for a supply chain network of Industry 4.0: a theoretical framework
Authors: Sundarakani Balan , Kamran Rukshanda , Maheshwari Piyush , Jain Vipul 
Published: February 2019

PurposeSupply chain is the area that requires effective and integrated means of communication, shared risk, collaboration and orchestration in order to work successfully and the cloud computing has lot to offer to this domain. Cloud computing has appeared as a modern paradigm in supply chain networks for creating intelligent industries of future. The purpose of this paper is to propose a framework that can transform supply chain stakeholders toward Industry 4.0.Design/methodology/approachCloud computing is attributed with increasing competitiveness by focusing on cost reduction, greater elasticity, flexibility and maximum utilization of resources which results in successfully achieving business goals. This paper proposes a Hybrid Supply Chain Cloud model, which integrates the infrastructure, the resources and the configurations of platforms.FindingsThis research paper is aimed at proposing a hybrid cloud that essentially helps in integrating the supply chain network with the flexibility and efficiency. It is important that a supply chain network adds value to ensure customer satisfaction and this can be best achieved by collaborating it with hybrid cloud.Research limitations/implicationsThis research provides a consistent central management and comprehensive view of all computing resources, which gives organizations the knowledge they need to optimize workload placement.Practical implicationsThe findings derived from this research aim to facilitate policy makers and practitioners to develop effective courses of action in current and future supply chain management. Therefore, upon implementation, this model can provide long-term benefits for the organizations by improving the overall efficiency of its supply chain network.Originality/valueThe proposed hybrid cloud will provide deep level of integration in Industry 4.0 situation and thereby brought up portable comprehensive infrastructure based on resources and required configuration in real-time environment.
Measuring university efficiency
Authors: Duan Sophia Xiaoxia 
Published: February 2019

Purpose
Public universities worldwide are under growing pressure to increase efficiency. Understanding how teaching and research contribute to the overall efficiency of university operations is of great importance for universities to improve their performance. This paper aims to discuss this issue.

Design/methodology/approach
This paper adopts a holistic approach to evaluate university efficiency from three perspectives including overall university operations efficiency, university teaching efficiency and university research efficiency. It applies the technique of data envelopment analysis to 36 Australian universities during the period 2011–2015 to evaluate their relative efficiency from these three perspectives. A strategic group analysis is further conducted for exploring the source of inefficiency of an individual university in its respective strategic group.

Findings
This study reveals that Australian universities maintain a comparatively high level of efficiency in terms of overall operations and research during the period 2011–2015. Teaching efficiency, however, is underwhelming during this period. It further shows that universities with low efficiency seeking to improve their overall operations efficiency can allocate the limited resource to teaching instead of research.

Practical implications
This study is crucial to both Australian government and Australian universities. The government is provided with the information about the optimum performance levels for universities under certain fixed resource. As a result, resources or funding can be allocated based on the performance ranking. The efficiency information is also in demand among Australian universities. In order to successfully strive for more funding from the federal government in an environment of increased competition, universities need to not only know their relative position among their peers, but also get guidelines on how to improve their performance.

Originality/value
The novelty of this study lies in the decomposing of efficiency models to identify inefficiencies in university operations. Such a study provides individual universities with valuable information on how they can make full use of their resources to improve their efficiency in an increasingly competitive environment.
Transit advertising in corporate branding: a multilevel study
Authors: Ngan Henrique F. Boyol , Yang Fiona X. 
Published: February 2019

PurposeThe purpose of the present study is to examine the effectiveness of tourist shuttle bus advertising for the corporate brand image of gaming and hospitality operators.Design/methodology/approachGrounded in the theoretical framework of Message Response Involvement (MRI) theory, a multilevel design with hierarchical modeling was adopted to examine the hypothesized paths between consumers’ message processing components and corporate brand equity. The moderating effects of shuttle bus design were also investigated. The data were collected via a self-administered questionnaire from 595 tourists visiting Macao.FindingsThe results indicated that advertising effectiveness (i.e., corporate brand equity) was largely dependent on consumers’ motivation and ability to process information. When design was included as a moderator, it enhanced the influence of consumers’ motivation to process information on advertising effectiveness.Research limitations/implicationsThe findings highlight the importance of tourist shuttle buses as an advertising platform in the hospitality and gaming industry and depict important aspects of consumers and executional cues that corporations should focus on improving shuttle bus advertising effectiveness.Originality/valueThis study examines an underexplored, yet frequently used, advertising channel – the shuttle bus. Specifically, it offers a better understanding of transit advertising effectiveness from the corporate level (design) and individual level (consumers’ motivation, ability and opportunity) in the tourism and hospitality industry.
Supply chain management and organizational performance: the resonant influence
Authors: Duong Binh An Thi , Truong Huy Quang , Sameiro Maria , Sampaio Paulo , Fernandes Ana Cristina , Vilhena Estela , Bui Loan Thi Cam , Yadohisa Hiroshi 
Published: February 2019

PurposeA single supply chain management (SCM) practice will have a certain impact on organizational performance (OP). However, since it is placed in a system that many other practices are conducted simultaneously, the practice itself will interact with other ones (i.e. affect/be affected). As a consequence, the efficiency of the affected practice is increased and it is expected to maximize the impact of SCM practices on OP. This mechanism is named the “resonant” influence that is a new approach in the SCM literature. The purpose of this paper is to test the above mechanism toward an insight into the relationship between SCM and OP.Design/methodology/approachTwo models were compared: the competitive models only exist in direct effects; and the other contains relationships between practices that are able to show the mechanism of the resonant influence, i.e. the hypothetical model. A data set gained from Vietnamese garment enterprises was used to validate the mechanism of the resonant influence.FindingsEmpirical evidence from Vietnamese garment sector showed that the competitive models could explain 42.8, 26.3 and 34 percent variance of operational performance, customer satisfaction and financial performance, respectively. In the meantime, the hypothetical model containing the resonant influence is capable to explain 69.5, 33.1 and 57.3 percent. For the impact of each SCM practice on OP, all relationships in the hypothetical model are also greater than those in competitive ones. These results supported the mechanism of the resonant influence.Research limitations/implicationsThis research provides an insight into the relationship between SCM practices and OP. By the resonant influence, the effectiveness of each affected SCM practice itself is magnified and OP is also increased remarkably.Practical implicationsUnderstanding the resonant influence, companies can apply this mechanism to enhance effectiveness of SCM practices at the lowest cost. To this end, the SCM practices should be implemented simultaneously as an integrated system rather than independent ones and the structural model proposed in this study is able to be used as “a guide map” for applying this mechanism.Originality/valueThis is one of pioneer empirical studies in the SCM literature that proposed and validated the concept of “resonant influence.”
A decade of Finnish engineering education for sustainable development
Authors: Takala Annina , Korhonen-Yrjänheikki Kati 
Published: February 2019

Purpose
The paper aims to examine the current status and development of sustainable development in Finnish engineering education.

Design/methodology/approach
The study consists of interviews with key stakeholders supplemented with the analysis of documented material. Development is discussed in relation to the findings of collaborative strategy process in the year 2009.

Findings
The paper observes that the Finnish universities providing engineering education are committed to sustainable development in their strategies. However, a lot of work remains to be done before the strategies are implemented and sustainable development is integrated to all degree programs. Explicit knowledge and individual learning in clearly defined disciplinary boundaries have been the main focus of engineering education.

Practical implications
The paper suggests that engineers need to be provided with mental tools to cope with uncertainty, complexity and ambiguity. Key competencies include holistic understanding, communication and collaboration skills, ability and willingness for critical and reflective thinking, creativity, innovativeness and entrepreneurship. Thus, collaborative learning, open dialogue and innovation are at the heart of education for sustainable development.

Originality/value
This paper has a relatively wide approach as it analyses sustainable development in the context of Finnish engineering education both on institutional and societal levels and is based on a national project.
Displacement through incarceration: an opportunity for personal re-engagement
Authors: Eades David N. 
Published: February 2019

Purpose
The purpose of this paper is to highlight that interpersonal relations within a visits venue in a carceral space can be restorative. This provides implications for staff working in institutions to support a visits programme to assist those incarcerated.

Design/methodology/approach
The experiences of those formerly incarcerated are captured through an ethnography of engagement by way of semi-structured interviews and field notes. In methodology it draws upon the fields of criminology and prison sociology, and in particular using an ethnographic approach within the field of Carceral Geography.

Findings
Interpersonal relationships developed, with a “significant other” within the liminality of displacement, are therapeutic in nature and potentially contribute to ongoing healthier relationships than previously experienced, once a person is released from incarceration. These also assist those incarcerated transition into the community when released.

Research limitations/implications
The sample within the study was only small, did not include the impact of family members, nor the impact of not having visitors upon people who are incarcerated. The feedback received was all positive. Other people might have had alternative experiences that were not captured in this study.

Practical implications
A practical outcome of this research is to encourage the development of interpersonal relationships and the reconstruction of social networks for those incarcerated as a means of early intervention for their recovery and future progress reintegrating back into society.

Social implications
The impact of a significant other helps those formerly incarcerated to value the importance of close supportive relationships in contributing to the lives of others socially.

Originality/value
Assisting those incarcerated develop a relationship with a significant other provides a unique protective element as a social intervention. Staff within institutions have a unique role within their service to facilitate visitors and to encourage those incarcerated to connect with a significant other so as to help their mental health, support their general well-being and give them hope for the future.
Factors affecting the efficacy of the Australian indigenous business exemption
Authors: Storey Matthew 
Published: February 2019

Purpose
This paper aims to describe a qualitative research project that investigated factors leading to the very low use of the Australian Commonwealth Government’s indigenous business exemption (IBE), particularly from 2011 to 2015.

Design/methodology/approach
The project involved interviews with 12 selected stakeholders from Indigenous firms, procuring agencies and policy designers, which took place in 2016.

Findings
Analysis of the interviews suggested that poor use of the IBE was primarily attributed to risk aversion inside government and limited communication of the existence of the policy outside government.

Originality/value
A range of other factors and methods of overcoming these problems are also identified; principal amongst these is the need for procuring agencies to engage with Indigenous suppliers in a coordinated and deliberate fashion.
The effect of brand authenticity on consumer–brand relationships
Authors: Oh Hyunjoo , Prado Paulo Henrique Muller , Korelo Jose Carlos , Frizzo Francielle 
Published: February 2019

Purpose
This paper aims to explore the impact of brand authenticity on forming self-reinforcing assets (enticing-the-self, enriching-the-self and enabling-the-self), which subsequently influence the brand-self connectedness and consumers’ behavioral intentions.

Design/methodology/approach
The authors surveyed 347 consumers in the USA and Brazil and used structural equation modeling to test the relationship among brand authenticity, self-reinforcing assets, brand-self connectedness and behavioral intentions.

Findings
Brand authenticity was found to influence the self-reinforcing assets. In turn, the self-reinforcing assets promoted closeness toward the brand, thereby increasing the behavioral intentions of consumers to buy a product, visit a store/website in the future and recommend the brand to other people.

Practical implications
Marketing practitioners can use these results to promote better brand positioning by considering brand authenticity as a key factor in how consumers cognitively assess brands.

Originality/value
This paper shows that brand authenticity is a key antecedent of consumer–brand self-reinforcing assets.