bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Anticoagulation Management in Everyday Clinical Practice: An International Comparative Analysis of Work-as-Done Using the Functional Resonance Analysis Method
Authors: Damen Nikki L. , de Vos Marit S. , Moesker Marco J. , Braithwaite Jeffrey , de Lind van Wijngaarden Rob A.F. , Kaplan Jason , Hamming Jaap F. , Clay-Williams Robyn 
Published: July 2018

Objectives
Preoperative anticoagulation management (PAM) is a complex, multidisciplinary process important to patient safety. The Functional Resonance Analysis Method (FRAM) is a novel method to study how complex processes usually go right at the frontline (labeled Safety-II) and how this relates to predefined procedures. This study aimed to assess PAM in everyday practice and explore the usability and utility of FRAM.

Methods
The study was conducted at an Australian and European Cardiothoracic Surgery Department. A FRAM model of work-as-imagined was developed using (inter)national guidelines. Semistructured interviews with 18 involved professionals were used to develop models reflecting work-as-done at both sites, which were presented to staff for validation. Workload in hours was estimated per process step.

Results
In both centers, work-as-done differed from work-as-imagined, such as in the division of tasks among disciplines (e.g., nurses/registrars rather than medical specialists), but control mechanisms had been developed locally to ensure safe care (e.g., crosschecking with other clinicians). Centers had organized the process differently, revealing opportunities for improvement regarding patient information and clustering of clinic visits. Presenting FRAM models to staff initiated discussion on improvement of functions in the model that are vital for success. Overall workload was estimated at 47 hours per site.

Conclusions
This FRAM analysis provided insight into PAM from the perspective of frontline clinicians, revealing essential functions, interdependencies and variability, and the relation with guidelines. Future studies are warranted to study the potential of FRAM, such as for guiding improvements in complex systems.
Impact of Donor Core Body Temperature on Graft Survival After Heart Transplantation
Authors: Schnuelle Peter , Benck Urs , Krämer Bernhard K. , Yard Benito A. , Zuckermann Andreas , Wagner Florian , Szabo Gabor , Borggrefe Martin , Karck Matthias , Gummert Jan 
Published: July 2018

Background
A previous donor intervention trial found that induction of mild therapeutic hypothermia in the brain-dead donor reduced the dialysis requirement after kidney transplantation. Consequences on the performance of cardiac allografts after transplantation were not explored to date.

Methods
Cohort study investigating 3-year heart allograft survival according to spontaneous core body temperature (CBT) assessed on the day of organ procurement. The study is nested in the database of the randomized trial of donor pretreatment with low-dose dopamine (ClinicalTrials.gov identifier: NCT000115115).

Results
Ninety-nine heart transplant recipients who had received a cardiac allograft from a multiorgan donor enrolled in the dopamine trial were grouped by tertiles of the donor's CBT assessed by a mere temperature reading 4 to 20 hours before procurement (lowest, 32.0-36.2°C; middle, 36.3-36.8°C; highest, 36.9-38.8°C). Baseline characteristics considering demographics of donors and recipients, concomitant donor treatments, donor hemodynamic, and respiratory parameters as well as underlying cardiac diseases in recipients, pretransplant hemodynamic assessments, including pretransplant inotropic/mechanical support, urgency, and waiting time were similar. A lower CBT was associated with inferior heart allograft survival (hazard ratio, 0.53; 95% confidence interval, 0.31-0.93, per tertile; P = 0.02, and hazard ratio, 0.68; 95% confidence interval, 0.50-0.93°C; P = 0.02) when CBT was included as continuous explanatory variable in the Cox regression analysis.

Conclusions
A lower CBT in the brain-dead donor before procurement may associate with an unfavorable clinical course after heart transplantation. More research is required, before therapeutic hypothermia can routinely be used in multiorgan donors when a cardiac transplantation is intended.
Gender Differences in Medication Adherence Among Adolescent and Young Adult Kidney Transplant Recipients
Authors: Boucquemont Julie , Pai Ahna L.H. , Dharnidharka Vikas R. , Hebert Diane , Furth Susan L. , Foster Bethany J. 
Published: July 2018

Background.
Among kidney transplant recipients, gender differences in medication adherence may contribute to higher graft failure risks observed in girls and young women compared with boys and young men. Our aim was to determine whether adherence differs by gender, and whether gender differences vary by age in adolescent and young adult kidney transplant recipients.

Methods.
We examined data from the 3-month run-in period (no intervention) of the randomized Teen Adherence in Kidney transplant Effectiveness of Intervention trial. Adherence was monitored using electronic pillboxes in 136 patients (11–24 y) followed in 8 transplant centers in Canada and the United States. We used ordinal logistic regression with generalized estimating equations to estimate the association between gender and each of daily taking (proportion of prescribed doses taken) and timing (proportion of prescribed doses taken on time) adherence, considering effect modification by age (11–16 y vs 17–24 y).

Results.
No difference in taking adherence was observed by gender among participants aged 11 to 16 years (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.55–1.54), whereas among participants aged 17 to 24 years, women had significantly greater odds of higher taking adherence scores (OR, 3.03; 95% CI, 1.20–7.66) than men. Results were similar for timing adherence, with no difference among participants aged 11 to 16 years (OR, 1.03; 95% CI, 0.65–1.63) but a greater odds of higher timing adherence scores in women than in men among participants aged 17 to 24 years (OR, 3.26; 95% CI, 1.43–7.45). There were no differences in adherence assessed by self-report or SD of tacrolimus trough levels.

Conclusions.
Gender differences in adherence vary by age. Whereas younger adolescents show no adherence differences by gender, young women show much better adherence than young men.
Non-adhesive alginate hydrogels support growth of pluripotent stem cell-derived intestinal organoids
Authors: Capeling Meghan M. , Czerwinski Michael , Huang Sha , Tsai Yu-Hwai , Wu Angeline , Nagy Melinda S. , Juliar Benjamin , Song Yang , Sundaram Nambirajan , Takayama Shuichi , Alsberg Eben , Helmrath Michael , Putnam Andrew J. , Spence Jason R. 
Published: July 2018

SummaryHuman intestinal organoids (HIOs) represent a powerful system to study human development and are promising candidates for clinical translation as drug-screening tools or engineered tissue. Experimental control and clinical use of HIOs is limited by growth in expensive and poorly defined tumor-cell-derived extracellular matrices, prompting investigation of synthetic ECM-mimetics for HIO culture. Since HIOs possess an inner epithelium and outer mesenchyme, we hypothesized that adhesive cues provided by the matrix may be dispensable for HIO culture. Here, we demonstrate that alginate, a minimally supportive hydrogel with no inherent cell adhesion properties, supports HIO growth in vitro and leads to HIO epithelial differentiation that is virtually indistinguishable from Matrigel-grown HIOs. Additionally, alginate-grown HIOs mature to a similar degree as Matrigel-grown HIOs when transplanted in vivo, both resembling human fetal intestine. This work demonstrates that purely mechanical support from a simple-to-use and inexpensive hydrogel is sufficient to promote HIO survival and development.
DNA Methylation Network Estimation with Sparse Latent Gaussian Graphical Model
Authors: Ng Bernard , Jafarzadeh Sina , Cole Daniel , Goldenberg Anna , Mostafavi Sara 
Published: July 2018

AbstractInferring molecular interaction networks from genomics data is important for advancing our understanding of biological processes. Whereas considerable research effort has been placed on inferring such networks from gene expression data, network estimation from DNA methylation data has received very little attention due to the substantially higher dimensionality and complications with result interpretation for non-genic regions. To combat these challenges, we propose here an approach based on sparse latent Gaussian graphical model (SLGGM). The core idea is to perform network estimation on q latent variables as opposed to d CpG sites, with q<<d. To impose a correspondence between the latent variables and genes, we use the distance between CpG sites and transcription starting sites of the genes to generate a prior on the CpG sites’ latent class membership. We evaluate this approach on synthetic data, and show on real data that the gene network estimated from DNA methylation data significantly explains gene expression patterns in unseen datasets.
Functionally redundant forms of extended-spectrum beta-lactamases and aminoglycoside-modifying enzymes drive the evolution of two distinct multidrug resistance gene clusters in clinical populations of EXPEC
Authors: Kim Jay W. , Mira Portia , Chan Patricia P. , Lowe Todd M. , Barlow Miriam , Camps Manel 
Published: July 2018

AbstractWe evaluate the distribution of genetic markers for antibiotic resistance in 276 genomic sequences of Extraintestinal PathogenicE. colifrom two hospitals on the U.S. West coast. Plasmid-borne genes encoding drug-inactivating enzymes dominate the distribution of aminoglycoside andβ-lactam resistance markers. These genes can be assigned based on their distribution to two mutually exclusive complementarity groups (CGs: CG1 and CG2) with each displaying genetic linkage and minimal functional overlap. CG1 includes genes encoding OXA-1 and AAC(6’)-Ib-cr, frequently also CTX-M-15, and sometimes AAC(3)-IIe.2, a variant of AAC(3)-IIe; CG2 includes AAC(3)-IId tightly linked to TEM-1, and occasionally also to genes encoding CTX-M-14-likeβ-lactamases. This binary distribution of aminoglycoside andβ-lactamase resistance genes suggests a convergence between two different evolutionary solutions, and results in a ubiquitous functional redundancy in the clinical populations. CG1 and CG2 are largely carried in IncF plasmids, of which we distinguish seven classes based on Rpt-A1 sequence homology. Both CG1 and CG2 genes are found in two different IncF plasmid classes, demonstrating their pervasive mobility across plasmid backbones. Different CG genes and IncF plasmid classes are found in a wide range of MLSTs, highlighting the prevalence of horizontal gene transfer. We also identify at least five clonally expanding MLSTs, which represent high-risk clones: ST131, ST95, ST73, ST127, and ST69. The identification of clonally-expanding types, the discovery of CGs that are ubiquitously spread in diverse clinical strains, and the functional redundancy that these two groups represent have significant implications for monitoring and controlling the spread of resistance.
Knowledge transfer in interorganizational partnerships: what do we know?
Authors: Milagres Rosileia , Burcharth Ana 
Published: July 2018

PurposeThe purpose of this paper is to review the literature on knowledge transfer in interorganizational partnerships. The aim is to assess the advances in this field by addressing the questions: What factors impact knowledge transfer in interorganizational partnerships? How do these factors interact with each other?Design/methodology/approachThe study reports results of a literature review conducted in ten top journals between 2000 and 2017 in the fields of strategy and innovation studies.FindingsThe review identifies three overarching themes, which were organized according to 14 research questions. The first theme discusses knowledge in itself and elaborates on aspects of its attributes. The second theme presents the factors that influence interorganizational knowledge transfer at the macroeconomic, interorganizational, organizational and individual levels. The third theme focuses on the consequences, namely, effectiveness and organizational performance.Practical implicationsPartnership managers may improve and adjust contracts, structures, processes and routines, as well as build support mechanisms and incentives to guarantee effectiveness in knowledge transfer in partnerships.Originality/valueThe study proposes a novel theoretical framework that links antecedents, process and outcomes of knowledge transfer in interorganizational partnerships, while also identifying aspects that are either less well researched or contested and thereby suggesting directions for future research.
Agricultural production mode transformation and production efficiency
Authors: Liu Zimin , Yang Dan , Wen Tao 
Published: July 2018

Purpose
The purpose of this paper is to analyze the impact of farmers’ agricultural production mode transformation, from the perspective of agricultural division of labor and cooperation, on their agricultural production efficiency including technical efficiency, pure technical efficiency and scale efficiency.

Design/methodology/approach
This paper analyzes the impact of the agricultural production mode’s transformation on farmers’ agricultural production efficiency, based on the classical theory of division of labor and specialization, transaction costs and cooperation. It uses 2013 survey data from 396 farms in 15 Chinese provinces to explore the contributing factors of agricultural production efficiency using a double selection model (DSM), which can correct the endogenous selection bias in farmers’ decisions.

Findings
Farmers that participate in agricultural division of labor and cooperation means transform their agricultural production from a traditional self-sufficient mode to one that is specialized and intensive. Agricultural division of labor measured by farmers’ participation in an agricultural division of labor in the production stages, or in agricultural products, and agricultural cooperation measured by farmers’ participation in farmers’ cooperatives significantly and positively influence their agricultural production efficiency after correcting farmers’ endogenous selection bias.

Originality/value
This paper proposes a unified framework to analyze the impact of farmers’ agricultural production mode transformation on their production efficiency. Further, it builds a DSM for an empirical analysis to avoid the endogenous biases in farmers’ self-selection behavior. This paper also provides ways for policy makers to improve farmers’ agricultural production efficiency from the modern agricultural production perspective.
Human capital in top management teams seen through the lens of senior human resources managers
Authors: Garcia-Carbonell Natalia , Martin-Alcazar Fernando , Sanchez-Gardey Gonzalo 
Published: July 2018

Purpose
Despite the strong influence of Hambrick and Mason’s (1984) seminal work, the effects of top management team (TMT) characteristics on strategic processes remain unclear. This study aims to go beyond the traditional upper echelon theory and to propose a human capital taxonomy of TMTs from the perspective of top human resources managers.

Design/methodology/approach
The research integrates arguments from the strategic human capital and strategic issue diagnosis literatures. An exploratory cluster analysis was conducted in an attempt to describe different human capital typologies in TMTs in a sample of 120 Spanish companies.

Findings
The exploratory analysis showed three distinct human capital profiles: “technocratic teams”, “highly skilled teams” and “operational teams”. In addition, this paper provides preliminary results about the effects of each profile in the above taxonomy on strategic issue diagnostic processes, suggesting that “highly skilled teams” present the most appropriate combination of human capital attributes.

Practical/implications
This analysis provides a guide for top managers regarding the human capital needs they may face when interpreting strategic issues in strategy formation processes.

Originality/value
This paper makes a twofold contribution to the extant literature: proposing an analysis of TMTs’ human capital from a synergistic perspective (“human capital profiles”) instead of using the traditional “more is better” approach and providing preliminary explanations about how those human capital combinations contribute to success in the strategic issue diagnosis process.
Leadership: the complexities and state of the field
Authors: Clark Catherine Marie , Harrison Christian 
Published: July 2018

Purpose
The purpose of this paper is to advance contemporary cognisance of the leadership field and its current state, through the synthesis and development of earlier contributions. A taxonomy of evolutionary eras is tendered, from which future research opportunities can be extrapolated.

Design/methodology/approach
This paper conducts a narrative literature review of significant leadership literature. There is a focus on prominent contributions which are considered to have been highly influential within the field, while acknowledging other notable influences.

Findings
Leadership is found to be a multifaceted and evolving field, which continues to produce further research fields. This dynamism hinders the progression of leadership to achieve integration. Eleven interrelated eras of leadership, which hold varying research value, were found. While some eras superficially appear to be discredited, there is arguably scope for these to be developed in contemporary context. Currently, the leadership approaches which are replete with research opportunities include servant leadership, a skills approach and an entrepreneurial leadership.

Research limitations/implications
Leadership is a vast research area with numerous contributions to its body of work; therefore, this review has focused on prominent contributions and has not attempted to include all available literature. The dissemination of leadership literature has allowed for research gaps to emerge and future research recommendations to be drawn.

Originality/value
While there is an extensive body of leadership literature, there are few reviews of the literature. A comprehensive contemporary review facilitates an examination of the current complexities and state of the leadership field.
Management accounting practices, governing boards and competitive advantage of Ugandan secondary schools
Authors: Nkundabanyanga Stephen Korutaro , Muhwezi Moses , Tauringana Venancio 
Published: July 2018

PurposeThe purpose of this paper is to report on the results of a study carried out to determine the use of Management Accounting Practices (MAPR) in Ugandan secondary schools. The study also sought to determine whether MAPR and governing boards (board size, gender diversity and frequency of board meetings) influence the perceived competitive advantage.Design/methodology/approachThis study is cross-sectional and correlational. Data were collected through a questionnaire survey of 200 secondary schools. The data were analysed through ordinary least squares regression using Statistical Package for Social Scientists.FindingsThere are wide variations in MAP in terms of the extent to which the schools employ management accounting techniques. Also, MAP and governing boards have a predictive force on the schools’ competitive advantage. However, governing board’s size has no effect on competitive advantage. In terms of the control variables, the results suggest that while government school ownership has a positive effect on competitive advantage, the school’s size has no effect. There are intertwining relationships of frequency of board meetings, board size and school size.Research limitations/implicationsThe present study was limited to the secondary schools in Uganda which limits generalisability. Still, the results offer important implications for secondary schools’ governing boards, owners and for similar African governments who are a major stakeholder in the secondary school education system. The exact mechanism by which intertwining relationships of frequency of board meetings, board size and school size impact competitive advantage is not been explored in this paper. Future researchers may direct research effort in this endeavour.Originality/valueTo the authors’ knowledge, this is the first study to investigate use of MAPR in secondary schools and to provide evidence of their efficacy.
Perceptions and practice of peer assessments: an empirical investigation
Authors: Agrawal Anand , Rajapakse Damith C. 
Published: July 2018

PurposeThe purpose of this paper is to check the veracity of educators’ apprehensions about peer assessments by comparing them with the actual peer assessment scores. It also explores the levels of satisfaction and current usage of peer assessment tools among educators.Design/methodology/approachThe first phase of this study aims at providing insights into the educators’ apprehensions, their satisfaction and usage levels of peer assessments. The second phase involves analysis of peer assessment scores of 539 students in 117 teams. Findings from statistical analysis of peer assessment scores are compared against the apprehensions of educators.FindingsThe results do not support the apprehensions among educators about peer assessments. Findings on the usage, satisfaction levels of educators and their future intentions of using peer assessments are also presented in this paper.Research limitations/implicationsStudies with larger sample size, qualitative in-depth research on experiences, designs and conditions of successful peer assessments and studies based on users’ experiences of peer assessments will help in getting richer insights in this area.Practical implicationsResults of this study indicate a need for educators to shed their apprehensions and adopt online or offline peer assessments tools with trust and confidence.Originality/valueThis study is important due to the existence of contrary views, inconsistent results and lack of adequate familiarity about the use, efficacy and practice of peer assessments. Though previous studies have tried to establish the reliability of peer assessments, this study finds that educators are still apprehensive about peer assessments. This is a unique study as no previous research has attempted a comparative study to check the veracity of the apprehensions of educators about peer assessments using the actual peer assessment scores.
Teacher leadership in six secondary schools in Mauritius
Authors: Chukowry Dorine Marie Christiane 
Published: July 2018

Purpose
The purpose of this paper is to examine teacher leadership in six private secondary schools in Mauritius and establish the extent to which teachers are taking up leadership roles at schools’ level.

Design/methodology/approach
This study focusses on three high-performing and three less-performing private secondary schools in Mauritius. An interview was carried out with the six rectors (heads) of the selected schools.

Findings
Teacher leadership is an emerging phenomenon in the Mauritian educational context. The outcomes of this research have significance in providing guidance for policy development in this area concerning Mauritian education.

Research limitations/implications
Time and resources were the constraining factors. It was a survey of heads only and different responses could have been received if students and teachers had been included in this study. The ideal would have been to have a wider coverage of the survey.

Practical implications
This study shows how teacher leadership can impact schools in a positive manner. Results from this study confirm that the success of teacher leaders depends largely on the rector’s philosophy of power sharing in the setting in which they work.

Originality/value
This paper is a pioneer research paper focussing on teacher leadership in six private secondary schools in Mauritius. This original and unique piece of work offers the international audience a clear understanding of the teacher leadership phenomenon in Mauritius.