bluuebunny/crossref_metadata_2025_split huggingface dataset:
FET PET to differentiate between post-treatment changes and recurrence in high-grade gliomas: a single center multidisciplinary clinic controlled study
Authors: Puranik Ameya D. , Dev Indraja D. , Rangarajan Venkatesh , Jain Yash , Patra Sukriti , Purandare Nilendu C. , Sahu Arpita , Choudhary Amitkumar , Bhattacharya Kajari , Gupta Tejpal , Chatterjee Abhishek , Dasgupta Archya , Moiyadi Aliasgar , Shetty Prakash , Singh Vikas , Sridhar Epari , Sahay Ayushi , Shah Aekta , Menon Nandini , Ghosh Suchismita , Choudhury Sayak , Shah Sneha , Agrawal Archi , Lakshminarayanan N. , Kumar Amit , Gopalakrishna Arjun 
Published: November 2024

Abstract
Purpose
The clinico-radiological dilemma in post-treatment high-grade gliomas, between disease recurrence (TR) and treatment-related changes (TRC), still persists. FET (Fluoro-ethyl-tyrosine) PET has been extensively used as problem-solving modality for cases where MR imaging is inconclusive. We incorporated a systematic imaging and clinical follow-up algorithm in a multi-disciplinary clinic (MDC) setting to analyse our cohort of FET PET in post-treatment gliomas.

Methods
We retrospectively analyzed 171 patients of post-treatment grade III and IV glioma with equivocal findings on MRI. 185–222 MBq of 18 F-FET was injected and dedicated static imaging of brain was performed at 20 min. TBR (Tumor to background ratio) was used as semi-quantitative parameter. Cutoff of 2.5 was used for image interpretation. Imaging findings were confirmed with histopathological diagnosis, wherever available or in a multidisciplinary joint clinic based on serial imaging.

Results
121 of 171 patients showed recurrent disease on FET PET, on follow up, 109 were confirmed with recurrence; 7 patients showed TRC, whereas 5 were treated with bevacizumab, with no further clinico-radiological deterioration, thus confirming TRC. 50 patients showed TRC on FET PET, on follow up on follow up, 40 were confirmed as true-negative. 10 patients who showed TBR less than 2.5 had confirmed TR on subsequent MR imaging. The overall sensitivity and specificity was 91.6 and 76.9% respectively, with a diagnostic accuracy of 87.13%.

Conclusion
There is potential for FET PET to be used along with MRI in the post treatment algorithm of high-grade glial tumors.
IGA Approximations of Elastic Interfaces and their Defects in an Elastic Medium with Couple Stress
Authors: Zegpi Esteban , Casquero Hugo , Zhang Yongjie Jessica , Acharya Amit 
Published: November 2024

AbstractThe objective of this work is to develop and implement a computational algorithm for calculating stress and couple-stress fields induced by bulk and interfacial line defects such as dislocations and generalized disclinations within phase/grain boundaries. The thermodynamic driving forces on line and planar defects, responsible for coupled plasticity and interface motion, fully coupled to stress, couple-stress and applied boundary conditions are also computed. A continuum approach for small deformations is considered following the formulation outlined in Acharya and Fressengeas (Continuum mechanics of the interaction of phase boundaries and dislocations in solids. In: Differential Geometry and Continuum Mechanics, pages 123–165, 2015), extended herein in the thermodynamics to accommodate physically necessary ingredients that arose in the modeling in Zhang and Acharya (J Mech Phys Solids 119:188–223, 2018), Zhang et al. (J Mech Phys Solids 114:258–302, 2018). Constitutive relations are derived from kinematics, balance laws and from the use of the second law of thermodynamics in global form. One of the challenges presented by this approach is the inclusion of couple stresses, Toupin (Arch Rational Mech Anal 17(2):85–112, 1964), and the consequent treatment of 4th order systems arising from the equations of balances of linear and angular momentum. In order to deal with these equations, the classical FEM approach is replaced by iso-geometric analysis (IGA), as proposed by Hughes et al. (Comput Methods Appl Mech Eng 194(39):4135–4195, 2005). Results on stress and couple stress fields of the various defects involved are computed. Further, the coupling of the dislocation density with the eigenwall allows for the capturing of the shear parallel to the grain boundary, which has been observed experimentally and through molecular dynamics.
Comparative study of midterm outcomes between Roux-en-Y gastric bypass (RYGB), diverted one-anastomosis gastric bypass (D-OAGB), and one anastomosis gastric bypass (OAGB)
Authors: El Masry Mohamed Abdul Moneim , Abdul Rahman Islam , Elshal Mohamed Fathy Mahmoud , Abdul Moneim Ahmed Maher 
Published: November 2024

Abstract
Purpose
Diverted one anastomosis gastric bypass (D-OAGB) is a new procedure that entails performing Roux-en-Y diversion during OAGB to preclude post-OAGB bile reflux. This study aimed to compare the mid-term outcomes of Roux-en-Y gastric bypass (RYGB) and OAGB versus D-OAGB.

Methods
This is a retrospective study that encompassed the analysis of data from patients undergoing bypass surgeries from 2015 to May 2021. The patients’ data until 2 years of follow-up were compared.

Results
This study included 140 patients who underwent OAGB (n = 64), RYGB (n = 24), and D-OAGB (n = 52). In the OAGB, RYGB, and D-OAGB groups, complication rates were 3.1%, 8.3%, and 5.8%, respectively. At the 3-month and 6-month follow-ups, the OAGB and D-OAGB groups showed a statistically significant higher percentage of excess weight loss (EWL%). Otherwise, the weight measures and weight loss outcome were comparable among the three groups in the other follow-up visits (p > 0.05). There was a significantly lower number of gastroesophageal reflux disease (GERD) remission cases and a higher number of de novo GERD cases in the OAGB group.

Conclusion
D-OAGB demonstrated favorable outcomes, including lower early adverse events and superior weight loss results in the first 6 months post-surgery when compared to RYGB. The D-OAGB group also showed higher rates of GERD remission and lower de novo GERD occurrence than OAGB. Further research is warranted to validate these findings and expand our understanding of this innovative surgical approach.
Centor scores associated poorly with rapid antigen test findings in children with sore throat
Authors: Jääskeläinen Johanna , Renko Marjo , Kuitunen Ilari 
Published: November 2024

Abstract
The Finnish Current Care Guideline recommends rapid antigen tests as the primary diagnostic tool for both adults and children with Centor score ≥ 3. We aimed to analyze the association of Centor score and rapid antigen test positivity of group A streptococcal pharyngitis (GAS) in Finnish children. We performed a retrospective single-center study from July 2019 to June 2022. We included all children aged 0–15 years based on ICD-10 diagnostic codes for acute pharyngitis. We manually extracted the data from the electronic healthcare records. We extracted the information on Centor score signs and symptoms, rapid antigen tests, throat cultures, and C-reactive protein (CRP) levels. Comparisons were made between different groups by calculating a difference of two proportions with 95% confidence intervals. A total of 464 children were included and rapid antigen tests were taken from 433 (93.3%). We did not detect any significant association between rapid antigen test positivity and Centor scores. Sensitivity of Centor score ≥ 3 for rapid antigen test positivity was 22.3 (95% confidence interval 17.3–27.9) and specificity 79.0% (72.4–84.8). Positive throat culture was found in 17.1% of the patients with negative rapid antigen test. Centor scores correlated positively with CRP levels, but elevated CRP did not predict positive antigen test results. Conclusion: The Centor score alone does not seem to be of any utility in guiding the diagnosis of suspected streptococcal pharyngitis. Microbiological testing remains necessary for accurate diagnosis and CRP should not be used to differentiate viral and bacterial pharyngitis cases.

What is Known:

• The Centor score is a clinical prediction model for differentiating Group A streptococcal (GAS) pharyngitis from viral pharyngitis.

• Finnish Current Care Guideline recommends rapid antigen testing in patients with Centor score ≥ 3 for diagnosing GAS infections and antibiotics prescribed based on confirmed test results.

What is New:

• The Centor score alone does not seem to have any use in guiding the diagnosis of suspected streptococcal pharyngitis in children.

• Microbiological testing remains necessary for accurate diagnosis in patients with sore throat.
Five-year overall survival of early- and late-onset colorectal cancer in Medellín, Colombia: a comparative study
Authors: Ruiz-Grajales Álvaro Esteban , Correa-Cote Juan Camilo , Sánchez-Zapata Miguel Ángel , Orozco-Puerta Manuela María , Baena-García Juan Felipe , Castrillón-Martínez Esteban 
Published: November 2024

Abstract
Purpose
Early-onset colorectal cancer (CRC) (EOCRC, < 50 years) has distinct clinicopathological features from late-onset CRC (LOCRC, ≥ 50 years). However, evidence on survival outcomes is contradictory. We aimed to analyse the differences in 5-year overall survival (OS) between EOCRC and LOCRC.

Methods
A retrospective cohort study was conducted during 2018–2022. Individuals aged ≥ 18 years diagnosed with CRC at two hospitals in Medellín, Colombia were included. Clinicopathological and survival data were retrieved from the medical records and a public government database. Patients were categorized into EOCRC and LOCRC groups. Five-year OS rates were calculated using the Kaplan-Meier method and prognostic factors for OS were identified through Cox regression models.

Results
Among 1022 patients, 52.5% were female, and 13.5% (n = 138) had EOCRC. Patients with EOCRC showed higher 5-year OS rates than LOCRC patients (54% vs. 32%). Univariable analyses indicated a 37% lower risk of death for EOCRC compared to LOCRC (HR: 0.633, 95%CI: 0.476–0.840, p = 0.002). After multivariable analyses, advanced staging and higher tumour grading were prognostic factors for worse OS (HR: 2.127, 95% CI:1.405–3.220, p = 0.0001; and HR: 12.896, 95%CI: 6.310-26.355, p = 0.000; respectively), and being in the EOCRC group remained as a prognostic factor for higher OS (HR: 0.482, 95% CI: 0.336–0.690, p = 0.000).

Conclusion
EOCRC is associated with significantly better 5-year OS rates and prognosis compared to LOCRC. Advanced stage and higher tumour grading are predictors of lower OS among all CRC patients. These findings highlight the importance of age-related risk stratification and personalized therapeutic approaches in CRC.
Role of dedicated port cleaning devices in laparoscopic surgery
Authors: Nagano Shinnosuke , Fujii Shota , Momose Kota , Yamashita Kotaro , Saito Takuro , Tanaka Koji , Yamamoto Kazuyoshi , Makino Tomoki , Takahashi Tsuyoshi , Kurokawa Yukinori , Eguchi Hidetoshi , Doki Yuichiro , Nakajima Kiyokazu 
Published: November 2024

Abstract
Background
Various techniques have been used to prevent smudge on a laparoscope when inserting through trocars; however, there has been no standardized method. The purpose of this study was to compare the performance of different cleaning techniques with or without using dedicated devices, and to evaluate the features of cleaning devices.

Methods
The smudge was created in the standard 12-mm and 5-mm ports using pseudo-blood, and port cleaning was attempted using 5 different methods: (1) a surgical gauze + surgical forceps, (2) a surgical gauze + laparoscopic forceps, (3) a small laparoscopic gauze + laparoscopic forceps, (4) a cylinder-type cleaner (Endo Wiper; Osaki Medical), and (5) a swab-type cleaner (Port Cleaner; Hakuzo Medical). The “port cleaning rate” was calculated by measuring the absorbance of remained pseudo-blood after single cleaning procedure using UV spectrophotometry. In addition, the port cleaning rate was compared between two dedicated devices after multiple (5 times) cleaning procedures.

Results
The two dedicated devices had a statistically higher cleaning rate for 12-mm port than the methods using surgical gauze (p < 0.05). Regarding the 5-mm port, a swab-type cleaner showed the highest cleaning rate than the gauze method and a cylinder-type cleaner (p < 0.05). After multiple cleaning procedures for 12-mm port, cleaning rate of a swab-type cleaner decreased by an average of 5.4% (p = 0.044), but cleaning rate did not decrease for a cylinder-type cleaner. Regarding the 5-mm port, cleaning rate statistically decreased for both two dedicated devices (p < 0.01).

Conclusion
Higher port cleaning rates were observed in techniques using dedicated devices. A swab-type cleaner had better port cleaning rate in single use, especially for the 5-mm port. A cylinder-type cleaner showed higher durability in cleaning 12-mm port. The features of these dedicated devices should be well understood, and cleaning methods should be selected according to the environment and surgical techniques.
Inborn errors of metabolism in neonates and pediatrics on varying dialysis modalities: a systematic review and meta-analysis
Authors: Raina Manan , Doshi Kush , Myneni Archana , Tibrewal Abhishek , Gillen Matthew , Hu Jieji , Bunchman Timothy E. 
Published: November 2024

Abstract
Background
Some inborn errors of metabolism (IEMs) resulting in aberrations to blood leucine and ammonia levels are commonly treated with kidney replacement therapy (KRT). Children with IEMs require prompt treatment, as delayed treatment results in increased neurological and developmental morbidity.

Objectives
Our systematic review in neonates and pediatrics evaluates survival rates and reductions in ammonia and leucine levels across different KRT modalities (continuous KRT (CKRT), hemodialysis (HD), peritoneal dialysis (PD)).

Data sources
A literature search was conducted through PubMed, Web of Science, and Embase databases for articles including survival rate and toxic metabolite clearance data in pediatric patients with IEM undergoing KRT.

Study eligibility criteria
Cross-sectional, prospective, and retrospective studies with survival rates reported in patients with IEM with an intervention of CKRT, PD, or HD were included. Studies with patients receiving unclear or multiple KRT modalities were excluded.

Study appraisal and synthesis methods
Analysis variables included efficacy outcomes [% reduction in ammonia (RIA) from pre- to post-dialysis and time to 50% RIA] and mortality. The Newcastle Ottawa Risk of Bias quality assessment was used to assess bias. All statistical analyses were performed with MedCalc Statistical Software version 19.2.6.

Results
A total of 37 studies (n = 642) were included. The pooled proportion (95% CI) of mortality on CKRT was 24.84% (20.93–29.08), PD was 34.42% (26.24–43.33), and HD 34.14% (24.19–45.23). A lower trend of pooled (95% CI) time to 50% RIA was observed with CKRT [6.5 (5.1–7.8)] vs. PD [14.4 (13.3–15.5)]. A higher mortality was observed with greater plasma ammonia level before CKRT (31.94% for ≥ 1000 µmol/L vs. 15.04% for < 1000 µmol/L).

Conclusions and implications of key findings
Despite the limitations in sample size, trends emerged suggesting that CKRT may be associated with lower mortality rates compared to HD or PD, with potential benefits including prevention of rebound hyperammonemia and improved hemodynamic control. While HD showed a trend towards faster achievement of 50% RIA, all modalities demonstrated comparable efficacy in reducing ammonia and leucine levels.

Prospero registration
CRD42023418842.

Graphical abstract
Hyperkalaemic acidosis: blood pressure is the diagnostic clue
Authors: Zieg Jakub , Thomasová Dana , Libik Malgorzata , Sumnik Zdenek , Bockenhauer Detlef 
Published: November 2024

AbstractPseudohypoaldosteronism type 2 (PHA2) is a rare inherited condition of altered tubular salt handling. It is characterized by the specific constellation of hyperkalaemic hyporeninemic hypertension, hyperchloremic metabolic acidosis and hypercalciuria. Molecular genetic testing confirms the diagnosis in the majority of cases. Thiazides constitute effective treatment. Due to its rarity, the diagnosis is often delayed. We here present two children with PHA2, who were initially treated with fludrocortisone and bicarbonate complicated mainly by exacerbation of their hypertension. Discontinuation of their previous therapy and commencement of thiazide diuretics led to normalisation of their blood pressure and electrolyte and acid–base status.
Ascorbate: a forgotten component in the cytotoxicity of Cu(II) ATCUN peptide complexes
Authors: Heinrich Julian , Siddiqui Elisa , Eckstein Henrike , Naumann Michael , Kulak Nora 
Published: November 2024

AbstractIn 1983, Linus Pauling and colleagues reported about enhanced antitumor activity of the Cu(II) complex of the simplest ATCUN (amino terminal Cu(II) and Ni(II)-binding motif) peptide (NH2-Gly-Gly-His-COOH, GGH) in the presence of ascorbate as an additive. In the following 4 decades, structural modifications of this complex were implemented, however, anticancer activity could not be significantly increased. This has led to neglecting the ATCUN motif and its Cu(II) complexes as potential chemotherapeutic agents. Furthermore, the addition of ascorbate with its positive effect on the anticancer activity has fallen into oblivion. In this work, we compared Cu(II) GGH with Cu(II) ATCUN peptides bearing β-Ala instead of Gly at the 2nd position of the peptide sequence regarding their in vitro complex stability and cytotoxicity (MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and annexin V-FITC (fluorescein isothiocyanate) apoptosis assay) towards three cancer cell lines (AGS, HeLa and NCI-N87). Such an exchange of amino acids led to an up to three-fold higher cytotoxic effect in the presence of ascorbate. We thus achieved a significant increase in the otherwise moderate cytotoxicity of Cu(II) ATCUN-like complexes. Lipophilicity assays (n-octanol/water coefficient, log P values) of the studied complexes were used to evaluate differences in the antiproliferative activity.
Graphical abstract
Stimulant medication and symptom interrelations in children, adolescents and adults with attention-deficit/hyperactivity disorder
Authors: van der Pal Zarah , Geurts Hilde M. , Haslbeck Jonas M. B. , van Keeken Alex , Bruijn Anne Marijn , Douw Linda , van Rooij Daan , Franke Barbara , Buitelaar Jan , Lambregts-Rommelse Nanda , Hartman Catharina , Oosterlaan Jaap , Luman Marjolein , Reneman Liesbeth , Hoekstra Pieter J. , Blanken Tessa F. , Schrantee Anouk 
Published: November 2024

AbstractStimulant medication is effective in alleviating overall symptom severity of attention-deficit/hyperactivity disorder (ADHD), yet interindividual variability in treatment response and tolerability still exists. While network analysis has identified differences in ADHD symptom relations, the impact of stimulant medication remains unexplored. Increased understanding of this association could provide valuable insights for optimizing treatment approaches for individuals with ADHD. In this study, we compared and characterized ADHD symptom networks (including 18 ADHD symptoms) between stimulant-treated (n = 348) and untreated (n = 70) individuals with ADHD and non-ADHD controls (NACs; n = 444). Moreover, we compared symptom networks between subgroups defined by their stimulant treatment trajectory (early-and-intense use, late-and-moderate use). Stimulant-treated individuals with ADHD showed stronger associations between symptoms, compared with untreated individuals with ADHD and NACs. We found no differences in symptom networks between the stimulant treatment trajectory subgroups. Prospective longitudinal studies are needed to disentangle whether the identified differences stem from treatment or pre-existing factors.
Neurological, psychological, psychosocial complications of long-COVID and their management
Authors: Narayanan Sareesh Naduvil , Padiyath Sreeshma , Chandrababu Krishnapriya , Raj Lima , P. S. Baby Chakrapani , Ninan George Abraham , Sivadasan Ajith , Jacobs Alexander Ryan , Li Yan Wa , Bhaskar Anand 
Published: November 2024

AbstractSince it first appeared, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has had a significant and lasting negative impact on the health and economies of millions of individuals all over the globe. At the level of individual health too, many patients are not recovering fully and experiencing a long-term condition now commonly termed ‘long-COVID’. Long-COVID is a collection of symptoms which must last more than 12 weeks following initial COVID infection, and which cannot be adequately explained by alternate diagnoses. The neurological and psychosocial impact of long-COVID is itself now a global health crisis and therefore preventing, diagnosing, and managing these patients is of paramount importance. This review focuses primarily on: neurological functioning deficits; mental health impacts; long-term mood problems; and associated psychosocial issues, among patients suffering from long-COVID with an eye towards the neurological basis of these symptoms. A concise account of the clinical relevance of the neurological and psychosocial impacts of long-COVID, the effects on long-term morbidity, and varied approaches in managing patients with significant chronic neurological symptoms and conditions was extracted from the literature, analysed and reported. A comprehensive account of plausible pathophysiological mechanisms involved in the development of long-COVID, its management, and future research needs have been discussed.
Predictors of tolerability for postoperative adjuvant S1 plus docetaxel chemotherapy for gastric cancer: a multicenter retrospective study
Authors: Toyota Kazuhiro , Tanabe Kazuaki , Kano Mikihiro , Komo Toshiaki , Hotta Ryuichi , Yanagawa Senichiro , Saeki Yoshihiro , Tazawa Hirofumi , Ikeda Masahiro , Shishida Masayuki , Okano Keisuke , Ide Ryuta , Imaoka Yasuhiro , Takahashi Shinya , Ohdan Hideki ,   the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO), Fujikuni Nobuaki , Misumi Toshihiro , Hihara Jun , Tokumoto Noriaki , Sugiyama Yoichi , Yamamoto Yuji , Suzuki Takahisa , Sakashita Yoshihiro , Fukuda Toshikatsu 
Published: November 2024

Abstract
Background
Adjuvant docetaxel plus S1 (DS) chemotherapy after gastrectomy with D2 lymph node dissection is the standard treatment for stage III gastric cancer in Japan; however, some patients are unable to receive adequate drug administration because of the deterioration of their conditions. This study aimed to investigate the correlation between tolerability for postoperative adjuvant DS chemotherapy and prognosis, and the factors affecting tolerability.

Methods
This retrospective study involved patients with stage III gastric cancer who underwent curative resection between 2018 and 2021 from a multicenter database. Patients with a cumulative dose of docetaxel and S1 greater than 120 and 8400 mg/m2, respectively, were considered tolerable. The prognostic impact and factors predicting tolerability were analyzed.

Results
Of the 103 patients, the tolerable group comprised of 63 (61%) patients and had a significantly better 3-year recurrence-free survival than the intolerable group (83% vs. 64%, P = 0.02). Among the preoperative factors, only performance status (PS, P = 0.04) was significantly correlated with tolerability in the univariate analysis. Among the postoperative factors, PS (P = 0.001) and perioperative weight loss rate (P = 0.02) were significantly correlated with tolerability in the univariate analysis. The multivariate analysis showed significant differences in the PS (odds ratio [OR]: 4.94, 95% confidence interval [CI] 1.79–14.98, P = 0.002) and weight loss rate (OR: 1.10, 95% CI 1.01–1.21, P = 0.03).

Conclusions
Tolerance to postoperative adjuvant DS chemotherapy has a significant prognostic impact. Postoperative PS and perioperative weight loss rates were independent predictors of tolerability.