bluuebunny/crossref_metadata_2025_split huggingface dataset:
Halo Profiles and the Concentration–Mass Relation for a ΛCDM Universe
Authors: Child Hillary L. , Habib Salman , Heitmann Katrin , Frontiere Nicholas , Finkel Hal , Pope Adrian , Morozov Vitali 
Published: May 2018

Abstract
Profiles of dark matter-dominated halos at the group and cluster scales play an important role in modern cosmology. Using results from two very large cosmological N-body simulations, which increase the available volume at their mass resolution by roughly two orders of magnitude, we robustly determine the halo concentration–mass (c−M) relation over a wide range of masses, employing multiple methods of concentration measurement. We characterize individual halo profiles, as well as stacked profiles, relevant for galaxy–galaxy lensing and next-generation cluster surveys; the redshift range covered is 0 ≤ z ≤ 4, with a minimum halo mass of M
200c
∼ 2 × 1011
M
⊙. Despite the complexity of a proper description of a halo (environmental effects, merger history, nonsphericity, relaxation state), when the mass is scaled by the nonlinear mass scale M
⋆(z), we find that a simple non-power-law form for the c–M/M
⋆ relation provides an excellent description of our simulation results across eight decades in M/M
⋆ and for 0 ≤ z ≤ 4. Over the mass range covered, the c–M relation has two asymptotic forms: an approximate power law below a mass threshold M/M
⋆ ∼ 500–1000, transitioning to a constant value, c
0 ∼ 3 at higher masses. The relaxed halo fraction decreases with mass, transitioning to a constant value of ∼0.5 above the same mass threshold. We compare Navarro–Frenk–White (NFW) and Einasto fits to stacked profiles in narrow mass bins at different redshifts; as expected, the Einasto profile provides a better description of the simulation results. At cluster scales at low redshift, however, both NFW and Einasto profiles are in very good agreement with the simulation results, consistent with recent weak lensing observations.
Mass Modeling of Frontier Fields Cluster MACS J1149.5+2223 Using Strong and Weak Lensing
Authors: Finney Emily Quinn , Bradač Maruša , Huang Kuang-Han , Hoag Austin , Morishita Takahiro , Schrabback Tim , Treu Tommaso , Schmidt Kasper Borello , Lemaux Brian C. , Wang Xin , Mason Charlotte 
Published: May 2018

Abstract
We present a gravitational-lensing model of MACS J1149.5+2223 using ultra-deep Hubble Frontier Fields imaging data and spectroscopic redshifts from HST grism and Very Large Telescope (VLT)/MUSE spectroscopic data. We create total mass maps using 38 multiple images (13 sources) and 608 weak-lensing galaxies, as well as 100 multiple images of 31 star-forming regions in the galaxy that hosts supernova Refsdal. We find good agreement with a range of recent models within the HST field of view. We present a map of the ratio of projected stellar mass to total mass (f
⋆) and find that the stellar mass fraction for this cluster peaks on the primary BCG. Averaging within a radius of 0.3 Mpc, we obtain a value of

, consistent with other recent results for this ratio in cluster environments, though with a large global error (up to δf
⋆ = 0.005) primarily due to the choice of IMF. We compare values of f
⋆ and measures of star formation efficiency for this cluster to other Hubble Frontier Fields clusters studied in the literature, finding that MACS1149 has a higher stellar mass fraction than these other clusters but a star formation efficiency typical of massive clusters.
Antiviral Combination Therapy for Cytomegalovirus Infection in High-Risk Infants
Authors: Vora Surabhi B , Brothers Adam W , Waghmare Alpana , Englund Janet A 
Published: May 2018

Background Cytomegalovirus (CMV) infection is a major risk factor for mortality in infants with severe combined immunodeficiency (SCID) and other profound immune defects. Specific antiviral therapy must be initiated early and aggressively because of the potential for antiviral resistance, rapid dissemination and poor transplant outcomes. Combination antiviral therapy is routinely administered for some viral infections, but the value of this approach for the treatment of CMV is unclear. Here we explore a strategy of initial combination therapy for high-risk infants with CMV infection. Methods We reviewed medical records of infants ≤6 months of age hospitalized between 2007–2015 who received ganciclovir (GCV) or foscarnet (FOS) monotherapy or initial combination GCV + FOS for CMV disease. The combination therapy group consisted of severely immunocompromised infants being considered for haematopoietic cell transplantation (HCT). Results Four patients received initial combination antiviral therapy and 26 patients received initial monotherapy during the study period. Combination antiviral recipients demonstrated initial improvement in viraemia and two of three who continued with this therapy survived the infection. Clinically significant resistance mutations did not emerge. Toxicity was common; neutropenia, thrombocy-topenia and electrolyte abnormalities were the most frequent adverse events in both groups. Creatinine elevation was uncommon in both groups. Conclusions Combination GCV + FOS therapy may be a safe alternative to monotherapy in high-risk infants, especially those who are pre-transplant with primary immune deficiency syndromes and high viral loads.
Quelles limites temporelles au désir de devenir père par assistance médicale à la procréation ? Les incertitudes du droit français
Authors: Brunet Laurence 
Published: May 2018

Le droit français a posé des limites temporelles au désir des hommes infertiles de devenir père en recourant aux nouvelles techniques de procréation : il faut être vivant et en âge de procréer. La première limite ne prête pas à discussion, la seconde est beaucoup plus délicate à définir. Pourtant l’une comme l’autre sont aujourd’hui mises à l’épreuve. Trois configurations particulières permettent de le montrer, dans lesquelles l’incertitude sur les seuils légaux résulte de l’interprétation extensive ou dérogatoire qu’en font des juges ou bien d’une incohérence inhérente à la réglementation elle-même. Dans les trois hypothèses étudiées dans cet article, des paillettes de sperme congelé restaient à disposition alors même que l’homme était soit décédé, soit en fin de vie, soit d’un âge avancé.
Entre honte et culpabilité, la capacité d’être seule de la mère en présence de son enfant
Authors: Villecourt-Couchat Isabelle , Scotto di Vettimo Delphine 
Published: May 2018

L’article s’appuie sur la recherche-action d’une psychologue exerçant en crèche à propos de la capacité d’être seule de la mère en présence de son enfant. La mise en lien des concepts de solitude, honte et culpabilité avec les processus de la maternalité, en situation clinique, dans ce lieu d’accueil, permet d’analyser les situations traumatisantes vécues par quelques mères fragilisées et de faciliter leur passage à leur nouvelle identité maternelle. En interrogeant autrement la honte, souvent considérée dans son versant déficitaire, on s’aperçoit qu’elle peut avoir une fonction bénéfique et salvatrice et permettre à la mère de se reconnaître comme sujet-mère. Le « moi maternel » transformé peut alors intégrer la solitude comme une instance de reconstruction et de subjectivation.
La critique génétique et l’herméneutique ricœurienne
Authors: Picardi Roberta 
Published: May 2018

L’article envisage le rapport entre la génétique textuelle et l’œuvre de Ricœur dans une double perspective. D’une part, il s’agit de mettre à jour les convergences et les divergences entre la critique génétique et l’herméneutique ricœurienne du texte : si le principal point d’intersection réside dans l’identification entre écriture et création, les divergences relèvent par contre de la différence des notions de texte, sur lesquelles Ricœur et la critique génétique s’appuient ; d’autre part, l’article se concentre sur les spécificités de l’œuvre de Ricœur du point de vue génétique : la marque distinctive de l’écriture philosophique de Ricœur est à cerner dans l’ancrage de la rédaction dans un travail extraordinaire de documentation prérédactionnelle ; ce style d’écriture réfléchit à son tour la « voie longue » qui constitue notamment le trait distinctif de l’herméneutique ricœurienne par rapport à celle de Gadamer.
« Hegel et Husserl sur l’intersubjectivité » : la genèse longue d’un écrit de circonstance
Authors: Picardi Roberta , Pavan Chiara 
Published: May 2018

Bien qu’il s’agisse d’un écrit de circonstance l’essai de Ricœur « Hegel et Husserl sur l’intersubjectivité » est l’issue d’une gestation longue, que cet article se propose de reconstruire. Cette gestation longue présente en effet un double intérêt. Tout d’abord, elle nous donne un aperçu significatif du corps à corps spéculatif avec d’autres auteurs, tels que Hegel et Husserl, dont se nourrissent sans cesse l’écriture et la pensée de Ricœur. En outre, ce parcours génétique permet de suivre, pas à pas, l’itinéraire qui conduit Ricœur à abandonner la conception de l’intersubjectivité défendue dans les écrits des années 1950, dans lesquels il se réclamait principalement de Kant, selon une orientation à la fois anti-hégélienne et anti-husserlienne. C’est le mouvement non linéaire sous-tendant ce tournant que nous visons à mettre à jour, en nous concentrant sur deux segments de la genèse : les traces du questionnement qui aboutit à la conception du premier « schéma » de l’essai, et les notes sur la « Cinquième méditation » de Husserl.
A FEIRA LIVRE DE CORUMBÁ/MS NA FRONTEIRA BRASIL-BOLÍVIA
Authors: Espírito Santo Anderson Luis do , Da Costa Edgar Aparecido , Benedetti Alejandro Gabriel 
Published: May 2018

O propósito deste artigo é discutir a participação dos bolivianos nas feiras livres da cidade de Corumbá-MS na perspectiva de construção histórica da feira. Para tanto, foram realizados levantamentos bibliográficos, seguida de entrevistas utilizando um roteiro semiestruturado. Também ocorreram conversas informais com pessoas que residem a bastante tempo na cidade para levantar informações da história das feiras livres, utilizando a técnica do tipo bola de neve. Também foi realizado um censo da feira livre, computando todos os feirantes por barraca (contagem a partir da observação empírica). A partir da organização das informações coletadas é possível afirmar que os bolivianos têm uma participação histórica nas feiras livres da cidade de Corumbá-MS. Contudo, sua atuação como feirante é frequentemente questionada pelo Estado (na figura do governo municipal) a partir das pressões da associação dos comerciantes locais.
Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2
Authors: Lee Saseong , Kong Jin-Sun , You Sungyong , Kwon H. Moo , Yoo Seung-Ah , Cho Chul-Soo , Kim Wan-Uk 
Published: May 2018

Abstract
Fibroblast-like synoviocytes (FLSs) play a key role in the progression of rheumatoid arthritis (RA) as a primary component of invasive hypertrophied pannus. FLSs of RA patients (RA-FLSs) exhibit cancer-like features, including promigratory and proinvasive activities that largely contribute to joint cartilage and bone destruction. In this study, we hypothesized that the NF of activated T cell 5 (NFAT5), a transcription factor involving tumor invasiveness, would control the migration and invasion of RA-FLSs. Analyses of transcriptomes demonstrated the significant involvement of NFAT5 in locomotion of RA-FLSs and that tissue factor (TF; also known as coagulation factor III) and CCL2 were the major downstream target genes of NFAT5 involving FLS migration and invasion. In cultured RA-FLSs, IL-1β and TGF-β increased TF and CCL2 expression by upregulating NFAT5 expression via p38 MAPK. Functional assays demonstrated that NFAT5- or TF-deficient RA-FLSs displayed decreased lamellipodia formation, cell migration, and invasion under IL-1β– or TGF-β–stimulated conditions. Conversely, factor VIIa, a specific activator of TF, increased migration of RA-FLSs, which was blocked by NFAT5 knockdown. Recombinant CCL2 partially restored the decrease in migration and invasion of NFAT5-deficient RA-FLSs stimulated with IL-1β. NFAT5-knockout mouse FLSs also showed decreased expressions of TF and CCL2 and reduced cell migration. Moreover, KRN2, a specific inhibitor of NFAT5, suppressed migration of FLSs stimulated with TGF-β. Conclusively, to our knowledge, this is the first study to provide evidence of a functional link between osmoprotective NFAT5 and TF in the migration and invasion of RA-FLSs and supports a role for NFAT5 blockade in the treatment of RA.
Turning mirrors into windows: Knowledge transfer among indigenous healers in Limpopo province of South Africa
Authors: Maluleka Jan R. , Ngoepe Mpho 
Published: May 2018

Background: Knowledge transfer is an unavoidable process when it comes to indigenous knowledge especially in Africa, the continent known for its oral tradition. Such knowledge is in danger of being obliterated as a result of a number of factors, including lack of interest from younger generations and low life expectancy whereby knowledgeable people die before transferring it to the next generation as it is mostly not documented. Objectives: This qualitative study utilised hermeneutic phenomenology guided by the organisational knowledge conversion theory to investigate the transfer of indigenous knowledge by traditional healers in the Limpopo province of South Africa. Method: The study utilised a snowball sampling technique to determine the population. Data collected through interviews with traditional healers were augmented with observations done on two healers who were in the middle of their training when this study was conducted, as well as an analysis of records held by some healers. Results: The findings suggestthat knowledge of traditional healing is believed to be transferred to the chosen ones through dreams and visions. However, this knowledge seems to be transferred through mentorship and apprenticeship, as well as interactions with other healers. Conclusion: It is concluded that transferring knowledge of traditional healing goes beyond just transference; it is embedded as a belief system in many African communities. An in-depth study on the development of a framework to integrate indigenous knowledge of traditional healers into mainstream health system is recommended.
Reconectar con la audiencia joven. Narrativa transmedia para la transformación de la televisión de servicio público en España, Francia, Alemania y Reino Unido
Authors: Azurmendi Ana 
Published: May 2018

Las televisiones de servicio público de los países europeos están realizando un gran esfuerzo para reconectar con las audiencias jóvenes. El dato de la pérdida dramática de espectadores jóvenes (Ofcom 2016) empuja a los operadores televisivos hacia una adaptación del medio televisivo al entorno cultural convergente. Metodología: Se realizará una revisión tanto de la literatura sobre las audiencias jóvenes y narrativa transmedia, como de los principios de las instituciones de la Unión Europea sobre el servicio público audiovisual en la era digital. Finalmente, a partir de las aportaciones de la literatura y de la regulación europea, se examinarán los contenidos transmedia más exitosos de las televisiones públicas europeas, como los informativos webdocs de “Lab.rtve.es”, “Guernika. Pintura de Guerra” (2007) y “A History of Scotland” (2008); además de los contenidos de entretenimiento “El Ministerio del Tiempo” (2015-2016), “Fais pas ci, fais pas ça”, “Sherlock” (2010-2017), “Doctor Who” (2005-2017), “EastEnders” (1985), “Goazen!” (2016) y “Alpha 0.7 - Der Feind in dir” (2010). Resultados y conclusiones: Las iniciativas transmedia en las televisiones públicas europeas, siendo limitadas en su cantidad, representan un esfuerzo por integrar las nuevas narrativas en el servicio audiovisual público y por llegar al público joven.
Predictive Value of the Cognitive Performance Test (CPT) for Staging Function and Fitness to Drive in People With Neurocognitive Disorders
Authors: Burns Theressa , Lawler Katie , Lawler David , McCarten J. Riley , Kuskowski Michael 
Published: May 2018

Abstract
The Cognitive Performance Test (CPT) is a standardized occupational therapy assessment that examines cognitive integration with functioning in an instrumental activities of daily living context. Conventional cognitive measures provide diagnostic utility but do not fully address the functional implications. Ninety-one veterans diagnosed with cognitive impairment were evaluated. We compared the predictive value of the CPT with the Large Allen Cognitive Level Screen (LACLS), Mini-Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA) for the need to retire from driving versus ability to pass an on-road exam. Measures were also analyzed by diagnostic classification. CPT correctly classified a mild versus major neurocognitive disorder, whereas MMSE, MoCA, and LACLS did not differentiate the groups. A CPT cutoff score of &lt;4.7/5.6 showed 89% sensitivity for failing the road exam and 75% specificity for ability to pass. CPT discriminated functional level in neurocognitive disorders and had better predictive value for fitness to drive compared with conventional cognitive measures.
Leisure as an End, Not Just a Means, in Occupational Therapy Intervention
Authors: Chen Szu-Wei , Chippendale Tracy 
Published: May 2018

Abstract
Leisure is commonly treated as a means instead of an end goal of intervention. This approach, influenced by history and society’s past values, does not reflect the fact that leisure is meaningful and unique to its participants and has a significant effect on their health. On the basis of the core values of the occupational therapy profession and its role in the health care system, in this article we advocate that occupational therapists should expand their focus to include leisure as a goal of intervention. Although adopting this proposed approach may not be easy, given that it involves challenges in reimbursement for services, potential competition with other health professions, and a twisting of the deep-rooted existing values of occupational therapists, we believe the proposed solutions address these concerns and shed light on how to make leisure a valued goal of intervention.
Vertical distribution of aerosols over the Maritime Continent during El Niño
Authors: Cohen Jason Blake , Ng Daniel Hui Loong , Lim Alan Wei Lun , Chua Xin Rong 
Published: May 2018

Abstract. The vertical distribution of aerosols over Southeast Asia, a critical factor
impacting aerosol lifetime, radiative forcing, and precipitation, is examined
for the 2006 post El Niño fire burning season. Combining these measurements
with remotely sensed land, fire, and meteorological measurements, and fire
plume modeling, we have reconfirmed that fire radiative power (FRP)
is underestimated over Southeast Asia by MODIS measurements. These results are
derived using a significantly different approach from other previously
attempted approaches found in the literature. The horizontally constrained
Maritime Continent's fire plume median height, using the maximum variance of
satellite observed aerosol optical depth as the spatial and temporal
constraint, is found to be 2.04 ± 1.52 km during the entirety of the
2006 El Niño fire season, and 2.19±1.50 km for October 2006. This
is 0.83 km (0.98 km) higher than random sampling and all other past
studies. Additionally, it is determined that 61 (+6–10) % of the
bottom of the smoke plume and 83 (+8–11) % of the median of the smoke
plume is in the free troposphere during the October maximum; while
49 (+7–9) % and 75 (+12–12) % of the total aerosol plume and
the median of the aerosol plume, are correspondingly found in the free
troposphere during the entire fire season. This vastly different vertical
distribution will have impacts on aerosol lifetime and dispersal. Application
of a simple plume rise model using measurements of fire properties
underestimates the median plume height by 0.26 km over the entire fire
season and 0.34 km over the maximum fire period. It is noted that the model
underestimation over the bottom portions of the plume are much larger. The
center of the plume can be reproduced when fire radiative power is increased
by 20 % (with other parts of the plume ranging from an increase of 0 to
60 % depending on the portion of the plume and the length of the fire
season considered). However, to reduce the biases found, improvements
including fire properties under cloudy conditions, representation of
small-scale convection, and inclusion of aerosol direct and semi-direct
effects are required.
Steering operational synergies in terrestrial observation networks: opportunity for advancing Earth system dynamics modelling
Authors: Baatz Roland , Sullivan Pamela L. , Li Li , Weintraub Samantha R. , Loescher Henry W. , Mirtl Michael , Groffman Peter M. , Wall Diana H. , Young Michael , White Tim , Wen Hang , Zacharias Steffen , Kühn Ingolf , Tang Jianwu , Gaillardet Jérôme , Braud Isabelle , Flores Alejandro N. , Kumar Praveen , Lin Henry , Ghezzehei Teamrat , Jones Julia , Gholz Henry L. , Vereecken Harry , Van Looy Kris 
Published: May 2018

Abstract. Advancing our understanding of Earth system dynamics (ESD) depends on the
development of models and other analytical tools that apply physical,
biological, and chemical data. This ambition to increase understanding and
develop models of ESD based on site observations was the stimulus for
creating the networks of Long-Term Ecological Research (LTER), Critical Zone
Observatories (CZOs), and others. We organized a survey, the results of which
identified pressing gaps in data availability from these networks, in
particular for the future development and evaluation of models that represent
ESD processes, and provide insights for improvement in both data collection
and model integration. From this survey overview of data applications in the context of LTER and
CZO research, we identified three challenges: (1) widen application of
terrestrial observation network data in Earth system modelling,
(2) develop integrated Earth system models that incorporate process
representation and data of multiple disciplines, and (3) identify
complementarity in measured variables and spatial extent, and promoting
synergies in the existing observational networks. These challenges lead to
perspectives and recommendations for an improved dialogue between the
observation networks and the ESD modelling community, including co-location
of sites in the existing networks and further formalizing these
recommendations among these communities. Developing these synergies will
enable cross-site and cross-network comparison and synthesis studies, which
will help produce insights around organizing principles, classifications,
and general rules of coupling processes with environmental conditions.
A new pattern of the moisture transport for precipitation related to the drastic decline in Arctic sea ice extent
Authors: Gimeno-Sotelo Luis , Nieto Raquel , Vázquez Marta , Gimeno Luis 
Published: May 2018

Abstract. In this study we use the term moisture transport for precipitation
for a target region as the moisture coming to this region from its major
moisture sources resulting in precipitation over the target region (MTP). We
have identified changes in the pattern of moisture transport for
precipitation over the Arctic region, the Arctic Ocean, and its 13 main
subdomains concurrent with the major sea ice decline that occurred in 2003. The
pattern consists of a general decrease in moisture transport in summer and
enhanced moisture transport in autumn and early winter, with different
contributions depending on the moisture source and ocean subregion. The
pattern is statistically significant and consistent with changes in the
vertically integrated moisture fluxes and frequency of circulation types. The
results of this paper also reveal that the assumed and partially documented
enhanced poleward moisture transport from lower latitudes as a consequence of
increased moisture from climate change seems to be less simple and constant
than typically recognised in relation to enhanced Arctic precipitation
throughout the year in the present climate.