bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rats exhibit similar biases in foraging and intertemporal choice tasks
Authors: Kane Gary A. , Bornstein Aaron M. , Shenhav Amitai , Wilson Robert C. , Daw Nathaniel D. , Cohen Jonathan D. 
Published: December 2018

AbstractAnimals, including humans, consistently exhibit myopia in two different contexts: foraging, in which they harvest locally beyond what is predicted by optimal foraging theory, and intertemporal choice, in which they exhibit a preference for immediate vs. delayed rewards beyond what is predicted by rational (exponential) discounting. Despite the similarity in behavior between these two contexts, previous efforts to reconcile these observations in terms of a consistent pattern of time preferences have failed. Here, via extensive behavioral testing and quantitative modeling, we show that rats exhibit similar time preferences in both contexts: they prefer immediate vs. delayed rewards and they are sensitive to opportunity costs — delays to future decisions. Further, a quasi-hyperbolic discounting model, a form of hyperbolic discounting with separate components for short-and long-term rewards, explains individual rats’ time preferences across both contexts, providing evidence for a common mechanism for myopic behavior in foraging and intertemporal choice.
Molecular determinants of metazoan tricRNA biogenesis
Authors: Schmidt Casey A. , Giusto Joseph D. , Gregory Matera A. 
Published: December 2018

ABSTRACTMature tRNAs are generated by multiple post-transcriptional processing steps, which can include intron removal. Recently, our laboratory discovered a new class of metazoan circular RNAs formed by ligation of excised tRNA introns; we termed these molecules tRNA intronic circular (tric)RNAs. To investigate the mechanism of tricRNA biogenesis, we generated constructs that replace the native introns of twoDrosophilatRNA genes with the Broccoli fluorescent RNA aptamer. Using these reporters, we identifiedcis-acting elements required for tricRNA formation in both human and fly cells. We observed that disrupting the conserved anticodon-intron base pair dramatically reduces tricRNA levels. Although the integrity of this base pair is necessary for proper splicing, it is not sufficient. Furthermore, we found that strengthening weak base pairs in the pre-tRNA also impairs tricRNA production. We also used the reporters to identifytrans-acting tricRNA processing factors. We found that several known tRNA processing factors, such as RtcB ligase and components of the TSEN endonuclease complex, are involved in tricRNA biogenesis. Depletion of these factors inhibits tRNA intron circularization. Furthermore, we observed that depletion of Clipper endonuclease results in increased tricRNA levels. In summary, our work characterizes the major players inDrosophilatricRNA biogenesis.
Structural neuroimaging signatures of anorexia nervosa features in a mixed sample enriched for disease vulnerability
Authors: Miles Amy E. , Kaplan Allan S. , Nikolova Yuliya S. , Voineskos Aristotle N. 
Published: December 2018

ABSTRACTBrain-behavior relationships that could provide insight into risk-associated pathophysiology have not been thoroughly assessed in anorexia nervosa (AN). Therefore, we sought to identify grey and white matter signatures of AN symptoms and risk factors (trait anxiety, set-shifting impairment) in a sample enriched for AN vulnerability, including acute and remitted AN patients and their unaffected sisters (n = 72, aged 18 – 48 years). MRI/DTI data were acquired on a 3T scanner and processed with Freesurfer and FSL TBSS. Relationships between clinical variables of interest and regional subcortical volume, vertex-wise cortical surface architecture (thickness, surface area, local gyrification), and voxel-wise white matter microstructure (FA, MD) were tested with separate linear regressions, including age, BMI, lifetime AN diagnosis, and intracranial volume as covariates, where appropriate. Significance was determined using a Bonferroni-corrected threshold, p(t) ≤ 0.001. We detected distinct associations linking AN symptoms to lateral occipital cortical thickness and insular/cingulate gyrification and trait anxiety to lingual cortical thickness and superior parietal gyrification, and we detected overlapping associations linking AN symptoms and set-shifting impairment to frontoparietal gyrification. No other brain-behavior relationships emerged. Our findings suggest that variations in site-specific cortical morphology could give rise to core features of AN and shared temperamental and cognitive-behavioral risk factors for AN.
Microsecond Interaural Time Difference Discrimination Restored by Cochlear Implants After Neonatal Deafness
Authors: Rosskothen-Kuhl Nicole , Buck Alexa N , Li Kongyan , Schnupp Jan W H 
Published: December 2018

AbstractCochlear implants (CIs) can restore a high degree of functional hearing in deaf patients however spatial hearing remains poor, with many early deaf CI users reported to have no measurable sensitivity to interaural time differences (ITDs) at all. Deprivation of binaural experience during an early critical period is often blamed for this shortcoming. However, we show that neonatally deafened rats provided with precisely synchronized CI stimulation in adulthood can be trained to localize ITDs with essentially normal behavioral thresholds near 50 μs. Furthermore, neonatally deaf rats show high physiological sensitivity to ITDs immediately after binaural implantation in adulthood. The fact that our neonatally deaf CI rats achieved very good behavioral ITD thresholds while prelingually deaf human CI patients usually fail to develop a useful sensitivity to ITD raises urgent questions about whether shortcomings in technology or treatment may be behind the usually poor binaural outcomes for current binaural CI patients.
Data-Driven Analysis of Age, Sex, and Tissue Effects on Gene Expression Variability in Alzheimer’s Disease
Authors: Brooks Lavida R.K. , Mias George I. 
Published: December 2018

ABSTRACTAlzheimer’s disease (AD) has been categorized by the Centers for Disease Control and Prevention (CDC) as the 6thleading cause of death in the United States. AD is a significant health-care burden because of its increased occurrence (specifically in the elderly population) and the lack of effective treatments and preventive methods. With an increase in life expectancy, the CDC expects AD cases to rise to 15 million by 2060. Aging has been previously associated with susceptibility to AD, and there are ongoing efforts to effectively differentiate between normal and AD age-related brain degeneration and memory loss. AD targets neuronal function and can cause neuronal loss due to the buildup of amyloid-beta plaques and intracellular neurofibrillary tangles.Our study aims to identify temporal changes within gene expression profiles of healthy controls and AD subjects. We conducted a meta-analysis using publicly available microarray expression data from AD and healthy cohorts. For our meta-analysis, we selected datasets that reported donor age and gender, and used Affymetrix and Illumina microarray platforms (8 datasets, 2,088 samples). Raw microarray expression data were re-analyzed, and normalized across arrays. We then performed an analysis of variance, using a linear model that incorporated age, tissue type, sex, and disease state as effects, as well as study to account for batch effects, and including binary interaction between factors. Our results identified 3,735 statistically significant (Bonferroni adjusted p<0.05) gene expression differences between AD and healthy controls, which we filtered for biological effect (10% two-tailed quantiles of mean differences between groups) to obtain 352 genes. Interesting pathways identified as enriched comprised of neurodegenerative diseases pathways (including AD), and also mitochondrial translation and dysfunction, synaptic vesicle cycle and GABAergic synapse, and gene ontology terms enrichment in neuronal system, transmission across chemical synapses and mitochondrial translation.Overall our approach allowed us to effectively combine multiple available microarray datasets and identify gene expression differences between AD and healthy individuals including full age and tissue type considerations. Our findings provide potential gene and pathway associations that can be targeted to improve AD diagnostics and potentially treatment or prevention. (US).
Mitofusin 1 is required for the oocyte-granulosa cell communication that regulates oogenesis
Authors: Machado Thiago S. , Carvalho Karen F. , Garcia Bruna M. , Zangirolamo Amanda F. , Macabelli Carolina H. , Sugiyama Fabrícia H. C. , Grejo Mateus P. , Neto J. Djaci Augusto , Ribeiro Fernanda K. S. , Sarapião Fabiana D. , Meirelles Flávio V. , Guimarães Francisco E. G. , Pernas Lena , Seneda Marcelo M. , Chiaratti Marcos R. 
Published: December 2018

SUMMARYMitochondrial function, largely regulated by the dynamics of this organelle, is inextricably linked to oocyte health. While the proteins that modulate mitochondrial fusion, Mitofusin 1 (MFN1) and 2 (MFN2), are required for embryogenesis, their role in oocyte development remains unclear. Here we show that the oocyte-specific deletion ofMfn1, but notMfn2, results in a complete loss of oocyte growth and ovulation due to a block in folliculogenesis at the preantral-to-antral follicle transition. We pinpoint the loss of oocyte ovulation to disrupted oocyte-somatic cell communication –Mfn1-null oocytes are deficient for the production of the important somatic cell signaling factor GDF9. Unexpectedly, the double loss ofMfn1andMfn2mitigates the effects on oocyte growth and ovulation, which is explained by a partial rescue of oocyte-somatic cell communication and folliculogenesis. Together, this work demonstrates that mitochondrial function influences communication of oocyte with follicular somatic cells and suggests that the balanced expression of modulators of mitochondrial dynamics is critical for proper oocyte development.
Social representations of polydrug use in a Finnish newspaper 1990–2016
Authors: Savonen Jenni , Hakkarainen Pekka , Kataja Kati , Sakki Inari , Tigerstedt Christoffer 
Published: December 2018

Purpose
The purpose of this paper is to study the social representations of polydrug use in the Finnish mainstream media. Social representations are shared ways of talking about socially relevant issues and have ramifications on both individual and socio-political levels.

Design/methodology/approach
The social representations theory and the “What’s the problem represented to be?” analysis provided the theoretical framework. In total, 405 newspaper articles were used as data and analysed by content analysis and thematic analysis. The key tenets of the social representations theory, anchoring, objectifying and naturalisation, were used in data analysis.

Findings
The study found that polydrug use was written about differently in articles over the study period from 1990 to 2016. Three social representations were introduced: first, polydrug use as a concept was used to refer to the co-use of alcohol and medical drugs. This was seen as a problem for young people, which could easily lead to illicit drug use. Second, illicit drugs were included in the definitions of polydrug use, which made the social representation more serious than before. The typical polydrug user was portrayed as a person who was addicted to substances, could not quite control his/her use and was a threat to others in society. Third, the concepts were naturalised as parts of common language and even used as prototypes and metaphors.

Originality/value
The study provides a look at how the phenomenon of polydrug use is conceptualised in everyday language as previous research has concentrated on its scientific definitions. It also adds to the research of media representations of different substances.
Evaluating the impact of digital library database resources on the productivity of academic research
Authors: Rafi Muhammad , JianMing Zheng , Ahmad Khurshid 
Published: December 2018

PurposeDigital library database resources have a significant impact on stimulating the research culture in higher education. The use of digital databases makes it possible to understand intellectual growth, research productivity, planning and identification of user information needs. Evaluating the effectiveness of user database resource utilization and research, the purpose of this study is to assist management in developing an excellent academic policy.Design/methodology/approachThis study establishes a quantitative method to analyze the productivity of academic research using digital databases. The secondary data extracted from the databases of 52 universities provided by Higher Education Commission (HEC) and the literature published on the Institute of Scientific Information (ISI) Web of Science. The statistical technique simple linear regression was used to analyze the data for understanding the impact of independent variables the “digital databases” on the dependent variable “research productivity”.FindingsThe result of the coefficient of multiple determination,R-squared,R20.679, indicated 67 per cent impact of the predictor on the outcome variable. However, the standardized coefficient Beta 0.824 revealed 82 per cent impact of the individual predictor on the outcome variable. Overall, the result of linear regression showed a significant effect of independent variables on the dependent variable. Besides, the result of correlation and the strength of association between the database resources and the academic publication was significant (p< 0.005).Practical implicationsThis research work is a supportive tool for managing gaps and promoting the development of necessary measures to develop strategies and solutions to create a better academic environment. The ultimate use of standard database resources can foster higher academic research to develop innovative ideas and improve researchers’ cognitive abilities.Originality/valueFrom Pakistan’s point of view, this study is the first one that gives insight into the intellectual growth of young researchers in higher education. The study provides first-hand information on the use of database resources and their significant impact on the productivity of academic research.
Prescience evidence of the housing market and production sector performance nexus
Authors: Alola Andrew Adewale 
Published: December 2018

PurposeObservation of misalignment of the house prices with fundamentals in Malta was recently investigated (Vakili-Zad and Hoekstra, 2011; Micallef, 2018). As such, this study aims to investigate nexus evidence of the housing market and production sector performance in Malta by using quarterly data spanning from 2005Q1 to 2016Q4.Design/methodology/approachIndustrial expansion and development indicator-producer price index (ppi) and unemployment (uem) are used along with volatility index (vix) and fertility rate (frate) as control variables in a multivariate autoregressive distributed lag approach.FindingsPrecisely, the investigation reveals that any disequilibrium in the long-run equilibrium among these variables is subsequently corrected by the movement in the housing market vis-à-vis real residential property price. As the system is observed to adjust with a speed of 39.7 per cent in a situation of economic disequilibrium, the long-run impacts on the housing market are positive for ppi and vix but negative for frate and eum. The observed direction of the impacts in the short-run are the same as in the long-run for all variables. A reported sensitivity test indicates a very minimal differential impact for each variable in the long-run but with a significantly different adjustment parameter of 81.9 per cent. Also, the estimated system posits a very stable model that is void of serial correlation and heteroskedasticity.Research limitations/implicationsIn view of the vibrant nature of the real estate and the housing sector of the country, consideration of the effective policy instruments provided by this study is strongly encouraged. On a wider note, these practicable tools could further be recommended to other regional countries.Originality/valueThe research presents a novel perspective of the real estate and housing sector of Malta, specifically in the light of economic diversification. The country’s housing sector is studied in relation with the performance of other sectors for the first time.
Determinants of information quality in dyadic supply chain relationships
Authors: Myrelid Paulina , Jonsson Patrik 
Published: December 2018

PurposeThe purpose of this paper is to explore how different determinants impact specific information quality (IQ) dimensions of shared demand-related information in dyadic supply chain relationships.Design/methodology/approachThrough a qualitative case study of three manufacturer–supplier dyads in the European automotive industry, a range of methods are used to collect data about 168 possible IQ deficiency situations. IQ deficiencies are identified in 50 situations and determinants thereof are explored.FindingsFindings show how inter-organisational collaboration, intra-organisational process support and composite information sharing directly impact five pragmatic IQ dimensions (relevance, accessibility, credibility, understandability and ease of operation) – at times beneficially, detrimentally, varyingly and conflictingly. Furthermore, the findings show how the determinant impact on ease of use-related IQ dimensions is moderated by information sharing facets.Research limitations/implicationsThe paper extends previous research by showing how information sharing acts as both a determinant and moderator of pragmatic IQ. It furthermore details previous research by showing how previously examined determinants of IQ impact specific IQ dimensions.Practical implicationsThe generated propositions of how determinants impact pragmatic IQ can guide managers to identify key drivers of successful information sharing.Originality/valueSince IQ mediates the linkage between information sharing and performance, this research helps explaining conflicting results regarding the value of information sharing. It also guides several strands of future research, such as hypothesis testing and exploratory and conceptualising studies.
Disguise mechanisms in regulation definitions: the private health system
Authors: Ryngelblum Arnaldo L. , Giglio Ernesto M. , Silva Corrêa Victor 
Published: December 2018

PurposeStudies of institutional logics have emphasized two fundamental conceptions: first, that there is continuous competition between the various logics embedded in any context and, second, that certain mechanisms influence the promotion or modification of existing logics. The purpose of this paper is to contribute to these studies by broadening the propositions on the mechanisms used by the actors to disguise the fact that they are not prioritizing non-prevailing logics.Design/methodology/approachThe paper examines the disguise mechanisms used in the regulation of the private health field in Brazil, which has still been rarely explored in the literature on the theme. The research strategy was qualitative, involving documentary research that provided information to create a script for interviewing different actors in this field, such as health plan companies, service providers, medical associations, trade unions, regulatory agency, consumer defense organizations and the judiciary, lending credibility to the study.FindingsThe field data suggest important findings. Field actors pursue exerting influence in defining the outcomes of the institutional logics prevailing at each event. In this pursuit, they work to keep representative parts of prescribed practices non-transparent to allow them a margin in which to maneuver when confronted with a non-prevailing logic.Originality/valueThis paper emphasizes that, in any context, actors, while following the prescriptions of a prevailing logic, might have to disguise not following the prescriptions of other logics; thus, they will have to seek for mechanisms to do so. This paper, by identifying disguise mechanisms that operate in the specific field of private health in Brazil, finally sheds light on disguise mechanisms, contributing to the general literature on institutionalism.
See it and believe it? Conceptual model for exploring the recall and recognition of embedded advertisements of sponsors
Authors: Maricic Milica , Kostic-Stankovic Milica , Bulajic Milica , Jeremic Veljko 
Published: December 2018

PurposeThe purpose of this paper is to develop a conceptual model for exploring the recall and recognition of embedded advertisements of sponsors.Design/methodology/approachTo verify the proposed conceptual model on a particular sports competition, a questionnaire related to the UEFA Champions League sponsors in the season 2016/2017 was designed. The data were analysed using structural equation modelling.FindingsThe results provided support to the claim that higher involvement in a sport and higher exposure to a sponsored event lead to higher recall and recognition of embedded advertisements. Conversely, the same two factors alongside sponsor awareness do not affect the attitude towards sponsors. On the other hand, sponsor awareness and attitude towards sponsors have a direct positive role on the future purchase intention of sponsor products/services.Practical implicationsThe findings illustrate that to maximise the effectiveness of their embedded advertisements, sponsors should not merely concentrate on brand awareness, but should go beyond and attempt to improve the consumers’ positive perception of their products and services. Moreover, by sponsoring a sport event, the sponsors can be sure that their message will be effectively transmitted to the ones who are fans of the sport and the sponsored competition.Originality/valueThe present study empirically explores the factors which influence the recall and recognition of embedded advertisements and how the achieved level of sponsorship awareness impacts purchase intentions.
The importance of user-generated photos in restaurant selection
Authors: Oliveira Bruno , Casais Beatriz 
Published: December 2018

Purpose
User-generated content and online reviews are highly relevant in purchase decision in the hospitality sector, including restaurants, but there is a lack of knowledge about the effect of sharing pictures in this context. This study aims to focus on the relevance of user-generated photos in online platforms for restaurants’ selection.

Design/methodology/approach
A research was conducted with a sample of 319 residents of Porto region, who had at least one meal in a restaurant over the 30 days before the answer of the survey and had searched online to select the restaurant.

Findings
The results show that while doing online research about restaurants, it is important for potential consumers to find pictures of food and physical evidences of restaurants generated by other users. Findings also show that consumers find user-generated photos especially at websites of reviews, although the importance of restaurant owned platforms, such as official social media pages and websites.

Practical implications
The research results appeal restaurant managers to understand the importance of user-generated photos in online platforms by promoting photo sharing in their restaurants with appropriate marketing activities for that purpose.

Originality/value
This paper expands the state-of-the-art about the importance of user-generated content, focusing on the importance of photos from restaurants shared by consumers in online platforms.