bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ensemble method to predict target genes and pathways in uveal melanoma
Authors: Wei Chao , Wang Lei , Zhang Han 
Published: April 2018

AbstractObjectiveThis work proposes to predict target genes and pathways for uveal melanoma (UM) based on an ensemble method and pathway analyses. Methods: The ensemble method integrated a correlation method (Pearson correlation coefficient, PCC), a causal inference method (IDA) and a regression method (Lasso) utilizing the Borda count election method. Subsequently, to validate the performance of PIL method, comparisons between confirmed database and predicted miRNA targets were performed. Ultimately, pathway enrichment analysis was conducted on target genes in top 1000 miRNA-mRNA interactions to identify target pathways for UM patients. Results: Thirty eight of the predicted interactions were matched with the confirmed interactions, indicating that the ensemble method was a suitable and feasible approach to predict miRNA targets. We obtained 50 seed miRNA-mRNA interactions of UM patients and extracted target genes from these interactions, such as ASPG, BSDC1 and C4BP. The 601 target genes in top 1,000 miRNA-mRNA interactions were enriched in 12 target pathways, of which Phototransduction was the most significant one. Conclusion: The target genes and pathways might provide a new way to reveal the molecular mechanism of UM and give hand for target treatments and preventions of this malignant tumor.
The peripheral cannulas in extracorporeal life support
Authors: Strunina Svitlana , Hozman Jiri , Ostadal Petr 
Published: April 2018

Abstract
Femoral cannulation is a minimally invasive method which is an alternative method for central cannulation. This review focuses on the parameters and features of the available peripheral cannulas. Nowadays there exist many peripheral cannulas in a variety of sizes, configurations and lengths to meet the specific needs of the patients. Modern cannulas are strong, thin-walled and one piece reinforced constructions. Furthermore, modern cannulas are manufactured from a biocompatible material and surface coatings are applied to the cannulas to reduce the activation of the clotting. When peripheral cannulas are applied, bleeding, thrombosis and hemolysis are the most common complications.
Numerical investigation of complete mandibular dentures stabilized by conventional or mini implants in patient individual models
Authors: Lohmann Anna , Keilig Ludger , Heinemann Friedhelm , Bourauel Christoph , Hasan Istabrak 
Published: April 2018

Abstract
Poor stability of a complete denture is a common problem due to bone atrophy of the edentulous ridge. The aim of the present study was to analyze denture stability after receiving implants and to study the biomechanical properties of denture implants and the bone bed using conventional or mini implants. Five models based on computed tomography (CT) data of edentulous patients were created. The overdentures’ connection to the implants was assured by means of ball head abutments and rubber rings. In three models, the denture was supported by two to four conventional implants and in two models, the overdenture was supported by three to five mini implants. The dentures were loaded according to the individual biting forces which was clinically measured by means of pressure sheets. After implantation, the biting forces and displacements of overdentures increased in comparison to complete dentures. Displacements and stresses were higher with mini implants than with conventional ones. Stress in the implants was markedly below the yield stress of titanium grade 5 (880 MPa). An increase in the stress in the bone around the implants was noticed as compared to the situation with complete dentures which was below the physiological range of bone loading (<4 MPa).
Force plates may be used for dynamic analyses of endoprostheses explantation procedures
Authors: Kohlhof Hendrik , Köhring Sebastian , Wirtz Dieter Christian , Witte Hartmut 
Published: April 2018

Abstract
The number of hip and knee arthroplasty replacement surgeries is increasing steadily. In combination with demographic aging and the number of periprosthetic complications, this development has lead to the phenomenon where the need for revision surgery is rising. The problem is, that, while implantation procedures of hip arthroplasties are more or less standardized, explantation is a non-standardized task for experienced specialists, due to the unpredictability of the adequate loosening method. The surgeon often only gets to decide on which tools and methods may be applied to detach the prosthesis, only after getting access to the operation site. The time taken to detach the prosthesis is hardly predictable and mainly depends on the surgeons’ skills. To gain objective data on the mechanics of explantation, new measurement methods are required. One technical base for studies on revision procedures are standard force plates, available in biomechanics laboratories.
Three-dimensional bioglass-collagen-phosphatidylserine scaffolds designed with functionally graded structure and mechanical features
Authors: Yang Chunrong , Wu Huazhong , Chen Shou , Kang Guangyu 
Published: April 2018

Abstract
The development of scaffolds featuring spatiotemporal controlled release of drugs is highly desirable. The goal of this study is to construct an inhomogeneous scaffold with gradient pore structure from top layer to bottom layer. The scaffolds were prepared using bioglass (BG), phosphatidylserine (PS) and steroidal saponins (SS) loaded collagen (COL) microparticles as the main components. The resulting scaffold constructs were characterized in terms of their morphology, drug release kinetics and mechanisms, as well as macroscopic form stability and mechanical properties. Pore interconnectivity and graded distribution were demonstrated using scanning electron microscopy (SEM). Such constructs have been further shown to be advantageous for temporal and spatial control of drug release and deposition in the scaffolds, with a potential to repair bone defect more precisely and effectively. Changes in the BG content resulted in distinct macroscopic form stability and mechanical properties to scaffolds. An increase in the BG content in scaffolds led to less volume swell as well as higher ultimate strength and compressive modulus, which makes the scaffolds mechanically adjustable according to certain structures and properties of different bone defect sites. The developed scaffolds may show promise for promoting bone tissue regeneration.
Einschätzung des Potenzials von fermentierten Milchprodukten mit ausgefallener Herstellungsweise in Österreich
Authors: Kapp Barbara , Pöchtrager Siegfried , Permoser Christoph 
Published: April 2018

Zusammenfassung
Fermentierte Milchprodukte wie Joghurt werden in ganz Europa, aber auch im eurasischen Raum, hergestellt und verzehrt. Je nach klimatischen Bedingungen unterscheiden sich die Mikroflora und dementsprechend auch das fertige Endprodukt. Neben Milchsäurebakterien können auch Hefen und Schimmelpilze zur Fermentation der Milch herangezogen werden. Am österreichischen Markt sind derzeit vor allem das Griechische Joghurt und High-Protein-Produkte wie das isländische Produkt Skyr gefragt. Da der Milchkonsum in Österreich jedoch stagniert, stellen Produktinnovationen für heimische Molkereien wichtige Umsatztreiber dar. Mithilfe dieser Studie soll geklärt werden, welche fermentierten Milchprodukte mit ausgefallener Herstellungsweise laut Experteneinschätzung das Potenzial für eine erfolgreiche Markteinführung in Österreich besitzen. Als Forschungsmethode dienten qualitative Expertenbefragungen. Um ein breites Spektrum abzudecken, wurden Vertreter aus der Forschung, dem Handel und der Produktion befragt.
Segmentierung der Kunden des Wiener Bio-Supermarktes „denn’s Biomarkt“ mithilfe einer Clusteranalyse
Authors: Sajovitz Pia , Pöchtrager Siegfried , Truffner Tobias , Auberger Verena 
Published: April 2018

ZusammenfassungObwohl der österreichische Bio-Fachhandel im Vergleich zum konventionellen Lebensmitteleinzelhandel nur einen geringen Anteil am Gesamtumsatz mit Bio-Lebensmitteln hat, nimmt die Anzahl der Bio-Fachhandelsgeschäfte konstant zu. Ziel der Arbeit war daher, die Kunden von Wiener Bio-Supermärkten (eine der Formen des Bio-Fachhandels) zu analysieren und auf Basis dieser Analyse Zielgruppen abzuleiten. Unter Verwendung eines standardisierten Fragebogens wurden 211 Kunden des Bio-Supermarktes „denn’s“ befragt. Im Rahmen der Befragung wurden soziodemografische, psychografische und kaufverhaltensbezogene Merkmale ermittelt. Die Zielgruppensegmentierung der Teilnehmer erfolgte mittels Clusteranalyse unter Verwendung zweier Clusterverfahren (Single-Linkage- und Ward-Verfahren). Die deskriptiven Ergebnisse dieser Erhebung zeigen, dass die Kunden des Wiener Bio-Supermarktes „denn’s“ vorwiegend weiblich sind. Allgemein sind die Kunden mittleren Alters und weisen ein vergleichsweise hohes Bildungs- und Einkommensniveau auf. Für die Befragten ist der Gesundheitsaspekt beim Bio-Lebensmitteleinkauf am relevantesten, gefolgt vom Umwelt- und Tierschutz. In Hinblick auf die Ernährungsgewohnheiten der Kunden sind über 60 % Vegetarier oder Veganer und rund 35 % achten auf eine gluten- oder laktosefreie Ernährung. Zudem sind die wesentlichsten Einkaufsmotive das Sortiment sowie Produktinformationen am Regal und eine deutliche Preiskennzeichnung. Mittels Clusteranalyse konnten zuvor vier unterschiedliche Kundenzielgruppen identifiziert werden.
Some results on discrete eigenvalues for the Stochastic Nonlinear Schrödinger Equation in fiber optics
Authors: Prati Laura , Barletti Luigi 
Published: April 2018

Abstract
We study a stochastic Nonlinear Schrödinger Equation (NLSE), with additive white Gaussian noise, by means of the Nonlinear Fourier Transform (NFT). In particular, we focus on the propagation of discrete eigenvalues along a focusing fiber. Since the stochastic NLSE is not exactly integrable by means of the NFT, then we use a perturbation approach, where we assume that the signal-to-noise ratio is high. The zeroth-order perturbation leads to the deterministic NLSE while the first-order perturbation allows to describe the statistics of the discrete eigenvalues. This is important to understand the properties of the channel for recently devised optical transmission techniques, where the information is encoded in the nonlinear Fourier spectrum.
Semi-Analytical method for the pricing of barrier options in case of time-dependent parameters (with Matlab® codes)
Authors: Guardasoni C. 
Published: April 2018

Abstract
A Semi-Analytical method for pricing of Barrier Options (SABO) is presented. The method is based on the foundations of Boundary Integral Methods which is recast here for the application to barrier option pricing in the Black-Scholes model with time-dependent interest rate, volatility and dividend yield. The validity of the numerical method is illustrated by several numerical examples and comparisons.
Cerebrospinal fluid free light chains as diagnostic biomarker in neuroborreliosis
Authors: Hegen Harald , Milosavljevic Dejan , Schnabl Christine , Manowiecka Andrea , Walde Janette , Deisenhammer Florian , Presslauer Stefan 
Published: April 2018

AbstractBackground:Free light chains (FLC) have been proposed as diagnostic biomarker in patients with inflammatory central nervous system diseases. The objective of this study was to investigate the diagnostic utility of intrathecal κ- and λ-FLC synthesis in patients with neuroborreliosis.Methods:κ- and λ-FLC were measured by nephelometry under blinded conditions in cerebrospinal fluid (CSF) and serum sample pairs of 34 patients with neuroborreliosis and compared to a cohort of 420 control patients. κ-FLC index was calculated as [CSF κ-FLC/serum κ-FLC]/[CSF albumin/serum albumin], and λ-FLC index in analogy.Results:κ-FLC and λ-FLC index were significantly elevated in patients with neuroborreliosis compared to the control group. At a specificity level of 95%, κ-FLC and λ-FLC index showed a diagnostic sensitivity of 88.2% and 100%. In comparison, IgM and IgG synthesis according to Reiber formula, IgG index >0.7 and OCB status reached a sensitivity of 83.9%, 44.1%, 58.8% and 64.7%.Conclusion:These findings support the diagnostic value of intrathecal FLC synthesis in neuroborreliosis patients and demonstrate a valid, easy and rater-independent alternative for the detection of an intrathecal immunoglobulin production.
Comparison of oral bioavailability of acetaminophen tablets, capsules and effervescent dosage forms in healthy volunteers
Authors: Fathi Mona , Kazemi Sohrab , Zahedi Farbod , Shiran Mohamad Reza , Moghadamnia Ali Akbar 
Published: April 2018

Abstract
A wide variety of acetaminophen dosage forms have been administered to relieve mild to moderate pain and fever, so far. The purpose of this study was to compare the oral bioavailability in healthy volunteers, of three of these dosage forms. We included healthy volunteers in our study and divided replace with placed them into three groups: tablet, capsule and effervescent. Each dosage form contained 500 mg of acetaminophen as active material. Blood samples were taken at 0.5, 1, 2, 4 and 8-hour intervals after receiving the dose. Acetaminophen blood levels were measured using HPLC method. Data were fit in a “one-compartment PK model”, using P-Pharm 1.5 software and analyzed under statistical tests. The maximum concentrations of acetaminophen in blood samples were measured at 1h after taking the drug (6.61±3.19 μg/ml, 11.29±3.94 μg/ml and 15.25±2.54 μg/ml in groups receiving capsule, tablet and effervescent, respectively). Pharmacokinetic (PK) data analysis & modeling from the three groups showed that the half-life of acetaminophen was 140.72 min in the tablet group, 140.29 min in capsule and 132.08 min in effervescent. The area under the blood levels curve were 47.04, 40.62 and 53.11 μgmin/ml, in tablet, capsule, and effervescent groups, respectively. Statistically significant differences in PK parameters were recorded as the study replace with we compared effervescent with tablets and capsule dosage forms (p < 0.05). According to the results, the effervescent form creates better PK parameters compared with tablet and capsule forms, therefore, it is suggested replace with we suggested that this form should be administer in cases of pain and fever to achieve quick drug efficacy.
Sever hepatitis induced by Epstein-Barr virus: case series
Authors: Roushan Mohammad Reza Hasanjani , Javanian Mostafa , Aliramaji Zahra , Ebrahimpour Soheil 
Published: April 2018

Abstract
Epstein-Barr virus (EBV) is a causative agent of infectious mononucleosis syndrome. This infection often resolves over a period of several months without outcomes, but may occasionally be complicated by a great variety of neurologic, hepatic, hematologic and respiratory complications. In the current report, we present the case histories of three patients with acute hepatitis following EBV infection when previously healthy. The patients showed fever, nausea, weakness, as well as yellowing of the skin, and then in the course of examination, sore throat. They were managed supportively and their clinical condition improved. Liver function tests such as ALT, AST, ALP, were undertaken and bilirubin were elevated. The serological tests for EBV infection were consistent with the acute phase of infection. The monospot test was also positive. The patients were managed supportively, and their critical condition was improved.
Predicting voice alternation across academic Englishes
Authors: Hundt Marianne , Röthlisberger Melanie , Seoane Elena 
Published: April 2018

Abstract
Academic writing in the second half of the twentieth century witnesses a notable decrease in be-passives in British and American English (AmE). This trend is more advanced in the soft than in the hard sciences; with the exception of AmE, moreover, regional variation is not highly significant. This paper aims to discover whether the use of passives is conditioned by the same factors across seven different varieties of English (both as a first and as an institutionalized second language). For this purpose, we automatically retrieve central be-passives and active transitives from syntactically annotated International Corpus of English corpora and code for factors that are likely to play a role in the choice between active and passive (such as the semantics of the participant roles or the length of the constituents). Our results show that, while the same factors predict the choice of a passive over an active verb phrase across first- and second-language varieties, subtle differences are found in the effect size that some factors (animacy, givenness and length of passive subject) have, notably in Hong Kong and Philippine English. Some (but not all) of these find an explanation in substrate influence.
Mixed Schemes for Fourth-Order DIV Equations
Authors: Fan Ronghong , Liu Yanru , Zhang Shuo 
Published: April 2018

Abstract
In this paper,
stable mixed formulations are designed and analyzed for the quad div problems under two frameworks presented in [23] and [22], respectively. Analogue discretizations are given with respect to the mixed formulation, and optimal convergence rates are observed, which confirm the theoretical analysis.
An Optimal Embedded Discontinuous Galerkin Method for Second-Order Elliptic Problems
Authors: Zhang Xiao , Xie Xiaoping , Zhang Shiquan 
Published: April 2018

Abstract
The embedded discontinuous Galerkin (EDG) method by Cockburn, Gopalakrishnan and Lazarov [B. Cockburn, J. Gopalakrishnan and R. Lazarov,
Unified hybridization of discontinuous Galerkin, mixed, and continuous Galerkin methods for second-order elliptic problems,
SIAM J. Numer. Anal. 47 2009, 2, 1319–1365]
is obtained from the hybridizable discontinuous Galerkin method by changing the space of the Lagrangian multiplier from discontinuous
functions to continuous ones, and adopts piecewise polynomials of equal degrees on simplex meshes for all variables.
In this paper, we analyze a new EDG method for second-order elliptic problems on polygonal/polyhedral meshes. By using piecewise polynomials of degrees

k
+
1

{k+1}

,

k
+
1

{k+1}

, k (

k
≥
0

{k\geq 0}

) to approximate the potential, numerical trace and flux, respectively, the new method is shown to yield optimal convergence rates for both the potential and flux approximations. Numerical experiments are provided to confirm the theoretical results.
Insight and recovery and the stigma of mental illness - analysis of the phenomenon of insight in schizophrenia and its correlations with the processes of stigma and self-stigma
Authors: Soroka Ewelina , Dziwota Kamila , Pawęzka Justyna , Olajossy Marcin 
Published: April 2018

Abstract
Does better insight associated with the process of recovery mean a stronger sense of mental illness stigma? This article presents the relationship between a multidimensional construct, which is the insight and the phenomena of stigma and self-stigma of patients diagnosed with schizophrenia. It is well known that the term insight contains: a sense of illness, the patient's attitude to its symptoms, explanation of the causes of the illness, attitude to the rationale of treatment and awareness of the risk of relapse. On the other hand, self-stigma occurs when the patient internalizes and refers to himself/herselfnegative and stigmatizing social attitudes, conditioned by the presence of conventionalbeliefs, strengthened by the media, and this weakens the process of recovery.
How much does good insight strengthen the patient on the way to fuller social functioning, and how much does it imprint stigma of mental illness and weaken its positionin society? The authors of the paper are discussing the subject of insight and stigma from the patient's perspective, over the patient’s attitude towards the diagnosis of schizophrenia, the process of recovery and the aspect of hope - important in recovery. These study of construct insight shows that the relationship insight-recovery-stigma is a multi-dimensional plane, dependent on various factors, that needs constant deepening and complementing with further research.
Measurement of HDO Products Using GC-TCD: Towards Obtaining Reliable Analytical Data
Authors: Zuas Oman , Budiman Harry , Mansur Dieni , Mulyana Muhammad Rizky 
Published: April 2018

Abstract
This paper reported the method development and validation of a gas chromatography with thermal conductivity detector (GC-TCD) method for the measurement of the gaseous products of hydrodeoxygenation (HDO). The method validation parameters include selectivity, precision (repeatability and reproducibility), accuracy, linearity, limit of detection (LoD), limit of quantitation (LoQ), and robustness. The results showed that the developed method was able to separate the target components (H2, CO2, CH4 and CO) from their mixtures without any special sample treatment. The validated method was selective, precise, accurate, and robust. Application of the developed and validated GC-TCD method to the measurement of by-product components of HDO of bio-oil revealed a good performance with relative standard deviation (RSD) less than 1.0% for all target components, implying that the process of method development and validation provides a trustworthy way of obtaining reliable analytical data.
Accurate determination of the CYP2D6 (*1/*4)xN genotype by quantitative PCR
Authors: Pondman Kirsten M. , van Schaik Ron H.N. , van der Weide Jan 
Published: April 2018

AbstractBackground:CYP2D6is responsible for the metabolism of approximately 25% of all drugs. The expression of cytochrome P450 2D6 (CYP2D6) is influenced by a combination of factors including polymorphisms in theCYP2D6gene. Analysis of theCYP2D6genotype is used to personalize the medication to a patient’s metabolism. Although many genotypes can be determined using standard genotype analysis, in some cases, an incomplete analysis is performed. TheCYP2D6genotype *1/*4 often occurs in combination with a multiplication of theCYP2D6gene, and is reported as (*1/*4)xN. Accurate determination of the multiplied gene is essential to provide a phenotype prediction for these patients. Duplication of the *1 gene leads to an extensive metabolizer genotype whereas multiplication of the *4 gene would not lead to extra functional enzyme and therefore provides an intermediate metabolizer phenotype.Methods:Here, a technique is described in which the copy numbers of both the *4 and *1 genes are determined using quantitative PCR techniques.Results and conclusions:This technique provides a method to predict the patient’sCYP2D6phenotype, and is therefore an important step toward personalized medicine.
Moses Maimonides und Immanuel Kant – negative Theologie, Skeptizismus und die Rolle des Unendlichen
Authors: Botwinick Aryeh 
Published: April 2018

Abstract
This paper argues that Kant’s argument in favor of the primacy of the categories over the world is embedded in a Maimonidean stream of theorizing. In terms of how words and concepts are configured in relation to possible entities outside of themselves, it recapitulates Maimonides’ argument concerning how to situate the human world in relation to God. The judge in Maimonides is the human being who ideally encodes in his character and personality the metaphysical stance reflected in Kant’s categories and Maimonides’ theorizing of God.