bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multigene expression signatures in early hormone receptor positive HER 2 negative breast cancer
Authors: Ovcaricek Tanja , Takac Iztok , Matos Erika 
Published: September 2019

Abstract

Background
The standard treatment of hormone receptor positive, HER2 negative early breast cancer (BC) is surgery followed by adjuvant systemic therapy either with endocrine therapy alone or with the addition of chemotherapy followed by endocrine therapy. Adjuvant systemic therapy reduces the risk of recurrence and death from BC. Whether an individual patient will benefit from adjuvant chemotherapy is an important clinical decision. Decisions that rely solely on clinical-pathological factors can often lead to overtreatment. Multigene signatures represent an important progress in optimal selection of high risk patients that might benefit from the addition of chemotherapy to adjuvant endocrine therapy.

Conclusions
Several signatures are already commercially available and also accepted by international guidelines. Oncotype DX and MammaPrint have been most extensively validated and supported by level IA evidence.
Dosimetric study for spine stereotactic body radiation therapy: magnetic resonance guided linear accelerator versus volumetric modulated arc therapy
Authors: Yadav Poonam , Musunuru Hima B. , Witt Jacob S. , Bassetti Michael , Bayouth John , Baschnagel Andrew M. 
Published: September 2019

Abstract

Background
Stereotactic body radiation therapy (SBRT) given in 1-5 fractions is an effective treatment for vertebral metastases. Real-time magnetic resonance-guided radiotherapy (MRgRT) improves soft tissue contrast, which translates into accurate delivery of spine SBRT. Here we report on clinical implementation of MRgRT for spine SBRT, the quality of MRgRT plans compared to TrueBeam based volumetric modulated arc therapy (VMAT) plans in the treatment of spine metastases and benefits of MRgRT MR scan.

Patients and methods
Ten metastatic lesions were included in this study for plan comparison. Lesions were spread across thoracic spine and lumbosacral spine. Three fraction spine SBRT plans: 27Gy to planning target volume (PTV) and 30Gy to gross tumor volume (GTV) were generated on the ViewRay MRIdian Linac system and compared to TrueBeamTM STx based VMAT plans. Plans were compared using metrics such as minimum dose, maximum dose, mean dose, ratio of the dose to 50% of the volume (R50), conformity index, homogeneity index and dose to the spinal cord.

Results
MRIdian plans achieved equivalent target coverage and spinal cord dose compared to VMAT plans. The maximum and minimum PTV doses and homogeneity index were equivalent for both planning systems. R50 was lower for MRIdian plans compared to VMAT plans, indicating a lower spread of intermediate doses with MRIdian system (5.16 vs. 6.11, p = 0.03).

Conclusions
MRgRT can deliver high-quality spine SBRT plans comparable to TrueBeam volumetric modulated arc therapy (VMAT) plans.
Pressupostos materialistas em dialética do concreto : para pensar cidades e patrimonialização
Authors: Costa Everaldo Batista da , Araújo Gilvan Charles Cerqueira de , Oliveira Rafael Fabrício de , Rúbio Rúbia De Paula , Freire Janaína Mourão 
Published: September 2019

A publicação do presente trabalho dá ênfase à importância do debate teórico-metodológico e epistemológico no contexto geográfico, em um momento de crise paradigmática enaltecedora de um pragmatismo tacanho e faceiro que acomete as ciências em geral. No âmbito geográfico, abundam em revistas nacionais e internacionais publicações destinadas a revelar o que se diz resultados de pesquisas comprometidas com o desvendamento das contradições socioespaciais. Entende-se que muito do que é produzido, sobretudo em teses e dissertações defendidas, depois publicadas, carecem de verdadeiro amadurecimento ou aprofundamento teórico e epistemológico. A crise se dá não diretamente pelo novo tempo da produção acadêmica, o qual se redimensionou de fato, no decorrer das últimas três décadas, dadas as facilidades informacionais de circulação e acesso aos acervos, às fontes e para a elaboração concreta do trabalho; esta crise advém, sim, de um descompromisso intelectivo generalizado com a produção do conhecimento original; crise fomentada pela ideologia numérica ou formal das publicações.
Uma esquerda marxista fora do lugar:
Authors: Farias Marcio 
Published: September 2019

Pretendo neste ensaio apresentar alguns pontos para discussão sobre o impasse que assola a esquerda marxista tradicional brasileira, suas novas formas e a esquerda pós-moderna diante da questão racial. Para tanto, resgato o debate do marxismo como teoria social que não só pode como já nos legou um amplo cabedal teórico sobre o tema, inclusive entre os intelectuais de esquerda no Brasil. No segundo momento, retomo as teses da recepção do marxismo no país, para, porfim, discutir a base teórica da esquerda contemporânea e as dificuldades e desafios para o marxismo brasileiro. Como considerações finais, assinalo a necessidade de um acerto de contas da teoria social marxista com o Brasil, naquilo que se vem produzindo enquanto ciência nas mais variadas áreas de conhecimento e que colocam em questão premissas retomadas e defendidas. Assim, o problema não é de ordem epistemológica e sim de apreensão do dado objeto de análise.
Estudio Comparativo de los Parámetros Cinéticos del Sistema Fe(CN)6 3-/4- en Carbón Vítreo y Diamante Dopado con Boro, Mediante Voltamperometría de Corriente Muestreada y Disco Rotatorio
Authors: Espinoza Montero Patricio J. , Fontana Uribe Bernando A 
Published: September 2019

Se llevó a cabo un estudio comparativo de los parámetros cinéticos tanto para la oxidación como para la reducción del sistema redox Fe(CN)6 3-/4- en un electrodo de disco rotatorio de diamante dopado con boro (RDE-BDD, por siglas en inglés) y un electrodo de disco rotatorio de carbón vítreo (RDE-VC, por sus siglas en inglés) mediante voltamperometría lineal y voltamperometría de corriente muestreada, y se compararon ambas técnicas.
Los resultados encontrados muestran que las dos técnicas son complementarias para sistemas cuasi-reversibles. Además, los resultados obtenidos sobre un electrodo de BDD se compararon con datos informados en la literatura reportados mediante voltamperometría cíclica en régimen estacionario. Se demostró la importancia del control de transferencia de masa durante los experimentos de estudio cinético del sistema en estudio.
BELAJAR DARI KARAKERISTIK BANGSA JEPANG DALAM MENGHARGAI KEBUDAYAAN
Authors: Fatonah Fatonah 
Published: September 2019

Abstrak: Belajar dari Karakeristik Bangsa Jepang dalam Menghargai Kebudayaan. Penelitian ini bertujuan untuk menghasilkan data kualitatif melalui pendekatan ekstrinsik, yaitu pandangan dan penilaian peneliti dari kacamata netral guna mengetahui dan memahami pandangan hidup bangsa Jepang, selain itu juga bertujuan untuk memahami karakteristik bangsa Jepang dalam budaya. Fokus penelitian ini adalah pemahaman tentang pandangan hidup masyarakat Jepang dan karakteristi-karakteristik bangsa Jepang dalam menghargai kebudayaan. Dengan menggunakan menggunakan metode deskriptif dalam ranah kebudayaan. Simpulannya, karakteristik masyarakat Jepang mencerminkan bangsa yang memiliki moralitas yang tinggi, mental dan etika yang kuat, tercermin dalam nilai-nilai dan norma mereka junjung tinggi, memiliki budi bahasa yang sopan, sikap yang ramah tamah, menjunjung tinggi kesetiaan, sangat menjagga perasaan dan menghormati hak orang lain, bangsa Jepang juga taat pada hukum, tata tertip, disiplin dan sangat menghagai waktu dan bersikap jujur. Gemar membaca dan senang menuntut ilmu. Semua hal tersebut sudah menjadi budaya bagi mereka.
KINERJA KEUANGAN DAN HARGA SAHAM
Authors: Atikah Siti , Hendri BS RR Sapto , Rakhmawati Intan , Suhaedi Wirawan , Rosyida Baiq 
Published: September 2019

Salah satu faktor yang menjadi bahan pertimbangan seorang investor atau calon investor saham dalam menentukan harga tawaran beli maupun tawaran jual adalah kinerja keuangan. Berbagai literatur menyatakan bahwa mahal atau murahnya harga saham ditunjukkan oleh kinerja keuangan. Penelitian ini bertujuan untuk menguji secara empiris arah atau hubungan kinerja keuangan dengan harga saham pada perusahaan sektor pertanian dan sektor pertambangan pada periode 2013 hingga 2015. Penelitian ini juga mengelompokkan kinerja keuangan berdasarkan harga saham yang kurang dari Rp 500 dan harga saham diatas Rp 500
Hasil analisis menunjukkan bahwa current ratio, debt to equity ratio, net profit margin, return on equity, earning per share, dan price earning rasio perusahaan sektor pertanian memiliki arah yang negatif terhadap harga saham, sedangkan arah positif ditunjukkan oleh asset turnover ratio, debt to total asset, financial leverage dan gross profit margin. Hasil yang berbeda terjadi pada harga saham perusahaan di sektor pertambangan. Aset turnover ratio, debt to total asset, financial leverage, gross profit margin dan price earning ratio perusahaan sektor pertambangan memiliki arah yang negatif terhadap harga saham.
Professional polyneuropathy: the state of the main arteries of the upper extremities
Authors: Kuprina N. I. , Kochetova O. A. , Shilov V. V. , Ulanovskaya E. V. 
Published: September 2019

Introduction. Professional polyneuropathy of the upper extremities is an example of the most common pathology due to physical overload and functional overstrain of the muscles of the upper extremities.The aim of the study was to study the ultrasound quantitative parameters of the anatomical structures of the arteries in normal and professional polyneuropathy.Materials and methods. Patients with polyneuropathy from physical overloads and functional overvoltage in hospital were examined by ultrasound in B-mode. The results of ultrasonic assessment of the morphological state of the main arteries of the forearm in professional polyneuropathy from physical overload and functional overvoltage are presented. The criteria for the selection of patients in the study were: the presence of severe clinical manifestations of polyneuropathy, confirmed by instrumental methods of the study, the data of sanitary and hygienic characteristics of working conditions, indicating contact with physical overload in the workplace, the absence of chronic diseases of the cardiovascular system (coronary heart disease, rheumatic, oncological, infectious diseases, heart defects, arrhythmias and conduction).Results. The study of ultrasound morphological features of the arteries of the upper extremities in professional polyneuropathy showed an increase in the intima-media complex, compaction of the structure of the vascular wall equally in the radial and ulnar arteries. The revealed changes were determined with the same frequency in men and women. The study of the right and left hands showed the presence of more pronounced changes on the side of the «working hand».Conclusions. Today the method of ultrasound examination of the main arteries of the middle caliber of the upper extremities is the only available and objective method of studying the morphological changes of the vascular system in professional polyneuropathy from functional overvoltage and physical overload. In comparison with the control group in patients with polyneuropathy, a significant decrease in the diameter of the vessels was determined on the limb, which has a predominant load. Ultrasonic changes are detected at the initial stages of professional polyneuropathy of the upper extremities.
RANCANG BANGUN MEDIA PEMBELAJARAN BAHASA ARAB UNTUK ANAK USIA DINI BERBASIS ANDROID
Authors: Puspa Putri Devi Afriyantari 
Published: September 2019

AbstrakBahasa merupakan hal yang mendasar bagi kehidupan manusia, selain untuk saran komunikasi juga untuk media penyerapan ilmu. Dewasa ini, kebutuhan penguasaan bahasa asing semakin meningkat karena banyaknya informasi yang beredar dalam bahasa asing, termasuk bahasa arab. Dalam proses belajar bahasa arab terdapat beberapa kendala yang muncul baik secara linguistik ataupun non-linguistik serta metode pembelajaran yang masih menggunakan cara konvensional. Seiring dengan berkembangnya teknologi, maka teknologi dirasa dapat menjadi solusi dari permasalahan yang timbul dalam pembelajaran bahasa arab. Hal ini dikarenaka teknologi dapat membuat media pembelajaran yang interaktif khususnya aplikasi pembelajaran yang berbasis android. Proses pembuatan aplikasi menggunakan software buildbox serta android studio. Hasil dari penelitian menunjukkan dari 30 responden, presentase rata-rata tingkat kepuasan pengguna sebesar 92,8%, dan sebesar 95,3% menyatakan bahwa aplikasi media pembelajaran bahasa arab yang dirancang dapat membantu proses belajar mengajar. Kata Kunci : Android, Buildbox, Media Pembelajaran, Bahasa arab
Rosmarinik Asidin Cisplatine Karşı Antisitotoksik ve Antigenotoksik Etkisinin A549 ve Beas-2B Hücre Hatlarında Araştırılması
Authors: VATAN Özgür 
Published: September 2019

Rosmarinik Asit (RA) birçok bitki türünde bulunan önemli bir fenolik bileşiktir. Çalışmada RA’nın, A549 (İnsan Akciğer Kanser Hücre Hattı) ve Beas-2B (İnsan Sağlıklı Bronşial Epitel Hücre Hattı) hücrelerinde, Cisplatin tarafından oluşturulan sitotoksik, genotoksik etki ve oksidatif strese karşın etkinliğinin in vitro olarak belirlenmesi ve böylelikle Cisplatin kemoterapisi sırasında hastalar tarafından kullanılabilecek RA içerikli bitkisel ürünlerin Cisplatin tedavisi üzerindeki olası etkilerinin belirlenmesi amaçlanmıştır. Bu amaca yönelik olarak sitotoksite belirlenmesinde XTT, genotoksite belirlenmesinde Komet ve oksidatif stres değerlerinin belirlenmesinde ise DCFH-DA yöntemleri kullanılmıştır. Yöntemlerde hücreler Cisplatin’in iki farklı dozuna (11, 22 µM) 24 saat süre ile maruz bırakılmıştır. Hücreler RA’nın üç farklı konsantrasyonuna (50, 100, 200 µM) hem tek başına hem de Cisplatin’in iki farklı dozu ile beraber uygulanarak 24 saat süre ile maruz bırakılmıştır. Sonuç olarak Cisplatin dozları tarafından arttırılan; sitotoksik etkiye karşın RA’nın kullanılan konsantrasyonlarının antisitotoksik aktivite, genotoksik etkiye karşın ise antigenotoksik aktivite gösterme potansiyeli olduğu belirlenmiştir. RA’nın bu aktivitelerinin temelinde de Cisplatin tarafından arttırılan oksidatif stres parametrelerini azaltıcı antioksidan özellik göstermesi olduğu belirlenmiştir. Sonuç olarak RA içeren bitkisel ürünlerin, özellikle Cisplatin kemoterapisi alan hastalarda bilinçsizce tüketiminin önlenmesi gerekliliği gösterilmiştir.
Comparison of ICU Outcomes between Intravenous Immunoglobulin and Plasma Exchange in Treatment of Mechanically Ventilated Patients with GuillainBarré Syndrome in a Neuro-Intensive Care Unit in a Govt. Hospital of Bangladesh: A Observational Cohort Study
Authors: Mallick Uzzwal Kumar , Chowdhury Mohammad Shah Jahirul Hoque , Hussain Mohammad Enayet , Asaduzzaman Mohammad , Islam Md Sirajul , Hoque Md Shamsul , Azam Silfat , Islam Md Zakirul , Mamtaz Farhana , Kabir Md Masud , Haque Kazi Ikramul , Chowdhury Md Tauhidul Islam , Hossain Mohammad Akter , Das Subir Chandra , Ara Ferdous 
Published: September 2019

Background: The management of Guillain-Barré Syndrome is very crucial for the outcome of the patient.
Objective: The aim of the study was to compare efficacy of IvIg(Intravenous Immunoglobulin) versus PE(Plasmaexchange) in treatment of mechanically ventilation adults with GBS in neuro-intensive care unit of Bangladesh.
Methodology: Thiswas a prospective, observationalcohort study, in a Neuro-ICU from 2017 to 2018. We included all patients with GBS who required mechanical ventilation (MV). We defined two groups: group 1 (group treated by IvIg: 0.4 g/kg/day for 5 days) and group 2 (group treated by PE: 5 PE during 10days, every alternate day). We collectedclinical and therapeutic aspects and outcome.
Results: A total number of 49 patients (34 in group 1 and 15 in group 2) were enrolled. The mean age was 37.4±9.2 years, with a male predominance (65.3%). on electrophysiological findings, in 4(32.7%) patients had acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN) in 26 (53.1%) patients and acute motor-sensory axonal neuropathy (AMSAN) was 3(6.1%)and NCS was not done in 4(8.2%) cases. The mean length of ICU stay was 20±19.10 days and 46.60±30.02 days in IVIG and PE group respectively. The ICU stay was significantly shorter (p = 0.001) in the IvIg group than PE group. Patients receiving IvIg were early weaned of MV (p = 0.002) compared to those receiving PE with a statistical significance. Also, duration of M/V (P=.002), Need of tracheostomy (p=.005) and over all surval rate (p=.007) was significantly in favoue of IvIg group than PE group. Out of 49 patients, total 3 patients were died and they all were AMAN variety.
Conclusion: Our work reveals a meaningful difference for the MV duration, ICU stay, weaning and excellent recovery in IvIg group compared to PE group in terms of less complcations.
Journal of National Institute of Neurosciences Bangladesh, 2019;5(2): 118-122
ANALISIS KUALITAS RANCANGAN PENELITIAN TINDAKAN KELAS GURU
Authors: Palobo Markus , Tembang Yonarlianto 
Published: September 2019

penelitian bertujuan untuk mendeskripsikan kualitas proposal penelitian tindakan kelas yang disusun oleh guru-guru SMP negeri 2 Merauke. Metode penelitian menggunakan analisis dokumen terhadap proposal penelitian guru. Populasi penelitian adalah seluruh proposal penelitian guru di SMP Negeri 2 Merauke dan objek penelitian adalah 5 proposal penelitian guru matematika, Bahasa Indonesia, Bahasa inggris, IPA dan IPS. Objek penelitian adalah hasil proposal penelitian hasil pekerjaan guru setelah diberikan pelatihan penyusunan proposal penelitian. Analisis data dilakukan dengan mendeskripsikan ketepatan ataupun kesalahan dari setiap komponen proposal penelitian tindakan kelas guru. Hasil penelitian diperoleh bahwa (1) judul penelitian masih terdapat judul yang belum lengkap. (2) Sistematika proposal sudah tepat dan permasalahan pada tata letak tulisan. (3) Latar belakang masalah terlalu umum belum menguraikan permasalahan secara spesifik dan solusi permasalahan yang diberikan belum diberikan kajian hubungan antara masalah dan solusi. (4) kajian teori masih minim referensi dan belum ada pengkajian secara mendalam terhadap teori-teori yang dituliskan. (5) penelitian relevan hanya menyajikan hasil penelitian relevan dalam bentuk angka. (6) gambar kerangka pikir sudah tepat namun deskripsinya belum sesuai dengan gambar. dan (7) sistematika metodologi penelitian sudah sesuai dan lengkap, kekurangan pada bagian instrument penelitian dan indicator keberhasilan belum sesuai secara.
Kata Kunci: Kualitas; Proposal; Penelitian
Comparasion Of The Therapeutic Effect Between SWD And Tens On Relieving Pain In Mechanical Low Back Pain Petients
Authors: Kartadinata Robby , Indriastuti Lanny 
Published: September 2019

Background : Low back pain (LBP) is the second cause of pain after headache and remains one of the most common symptoms for seeing a physician. About 90% of LBP is caused by mechanical factor. There are various physical modalities to relieve pain, such as, Short Wave Diathermy (SWD) and Transcutaneus Electrical Nerve Stimulation (TENS) which are proved to be useful to relieve pain. The aim of the study is to compare SWD and TENS on relieving pain in mechanical LBP patients.
Methods : A pre-posttest study in 36 outpatients, with subacute mechanical LBP, ranging from 30–55 years old, were randomly divided into two even groups, the SWD group and TENS group. The subjects received either SWD or TENS on lumbosacral area for 15 minutes, 3 times a week, with the interval of 2–3 days during 2 weeks. Visual Analogue Scale (VAS) was applied for pain assessments to all subjects before and 24 hours after the sixth therapy session.
Results : There was a reduction on VAS score in the SWD group from 4.56 ± 0.62 cm to 1.90 ± 0.51 cm (p<0.001). There was a reduction on VAS score in the TENS group from 4.64 ± 0.59 cm to
2.03 ± 0.50 cm (p<0.001). There was no significant difference on VAS score reduction between SWD and TENS group (p = 0.643). Conclusion : TENS therapy relieves pain in subacute mechanical LBP patients as good as SWD Therapy.
Keywords : Mechanical low back pain, SWD, TENS.
Pengaruh Suplementasi Medisco Putih Telur Terhadap Perubahan Kadar Albumin pada Pasien Bedah dengan Hypoalbumenia di RSUP Dr. Kariaidi Semarang
Authors: - Supriyatna 
Published: September 2019

Latar belakang : Makanan tinggi potein dapat meningkatkan dan mempertahankan kadar albumin. Modisco putih telur (MPT) merupakan suplementasi tinggi protein tinggi kalori yang dapat meningkatkan kadar albumin darah. Penelitian ini bertujuan untuk menganalisis pengaruh suplementasi MPT terhadap perubahan kadar albumin darah pada pasien hipoalbuminemia.
Metode : Penelitian Quasi Eksperimen pada pasien hipoalbuminemia di bangsal bedah RSUP Dr Kariadi Semarang pada bulan Agustus–September 2009 dan bulan Februari–Maret tahun 2010. Sampel diambil secara purposive terdiri dari 20 perlakuan dan 20 kontrol dengan kriteria inklusi umur 21 s/d 60 tahun, diet peroral bentuk makanan biasa atau lunak. Pasien dengan gangguan fungsi hepar dan ginjal serta menjalani operasi dalam 5 hari pengamatan dieksklusi. Kadar albumin darah sebelum perlakuan diambil dari rekam medik, evaluasi kadar albumin dilakukan pada hari ke-5. Hasil analisis dengan uji independent t test dan paired t test.
Hasil : Rerata kadar albumin darah hari pertama pada kelompok perlakuan adalah 2,5 mg/dl ± 0,22 dan kelompok kontrol 2,4 mg/dl
± 0,55. Evaluasi hari ke 5 kadar albumin darah pada kelompok perlakuan sebanyak 2,7 mg/dl ± 0,47 dan kelompok kontrol 2,2 mg/dl ± 0,53. Uji statistik didapatkan perbedaan bermakna pada perubahan kadar albumin antara kelompok perlakuan dan kelompok kontrol (p=0,002).
Simpulan : Terdapat perbedaan bermakna kadar albumin antara responden yang diberi MPT dengan yang tidak diberi MPT.
Kata kunci: hipoalbumin, kasus bedah, modisco putih telur.
Primary Percutaneous Coronary Intervention (Primary PCI), Senjata "Baru" Untuk Melawan Serangan Jantung Akut
Authors: Rifki Sodiqur 
Published: September 2019

Serangan jantung akut atau infark miokard akut (acute myocardial infarction) adalah suatu momok yang mengerikan. Keluhan nyeri dadanya begitu menakutkan sehingga bisa membuat seorang perokok fanatik yang sudah puluhan tahun merokok dan tidak pernah mau mendengar saran dari siapapun, termasuk cucunya, tiba- tiba mau berhenti merokok seketika. Seorang yang pernah mengalami serangan ini mengatakan bahwa rasa ajal mau menjemput (feeling of death) itu begitu menakutkan, sehingga membuatnya tak ingin mengalaminya lagi.
Dari semua pasien infark miokard, 25–35% akan meninggal sebelum mendapat pengobatan, umumnya disebabkan oleh gangguan irama jantung yang letal, yaitu fibrilasi ventrikel.1,2 Pasien yang berhasil sampai ke rumah sakit dari tahun ke tahun semakin menurun angka kematiannya. Penurunan tersebut terjadi karena beberapa hal, terutama sejak adanya perawatan CCU (Coronary Care Unit) dan dikembangkannya terapi reperfusi baik secara farmakologis dengan obat fibrinolitik maupun reperfusi mekanik dengan percutaneous coronary intervention (PCI). Sayangnya, data nasional Indonesia belum ada, tetapi analisis data register nasional di Amerika Serikat menunjukkan penurunan angka kematian pasien infark miokard yang mendapatkan terapi reperfusi jauh lebih rendah (5,7%), dibandingkan dengan yang tidak mendapatkan terapi reperfusi (14.8%).