bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pitch Shifting With the Commercially Available Eventide Eclipse: Intended and Unintended Changes to the Speech Signal
Authors: Heller Murray Elizabeth S. , Lupiani Ashling A. , Kolin Katharine R. , Segina Roxanne K. , Stepp Cara E. 
Published: June 2019

PurposeThis study details the intended and unintended consequences of pitch shifting with the commercially available Eventide Eclipse.MethodTen vocally healthy participants (M= 22.0 years; 6 cisgender females, 4 cisgender males) produced a sustained /ɑ/, creating an input signal. This input signal was processed in near real time by the Eventide Eclipse to create an output signal that was either not shifted (0 cents), shifted +100 cents, or shifted −100 cents. Shifts occurred either throughout the entire vocalization or for a 200-ms period after vocal onset.ResultsInput signals were compared to output signals to examine potential changes. Average pitch-shift magnitudes were within 1 cent of the intended pitch shift. Measured pitch-shift length for intended 200-ms shifts was between 5.9% and 21.7% less than expected, based on the portion of shift selected for measurement. The delay between input and output signals was an average of 11.1 ms. Trials shifted +100 cents had a longer delay than trials shifted −100 or 0 cents. The first 2 formants (F1, F2) shifted in the direction of the pitch shift, with F1 shifting 6.5% and F2 shifting 6.0%.ConclusionsThe Eventide Eclipse is an accurate pitch-shifting hardware that can be used to explore voice and vocal motor control. The pitch-shifting algorithm shifts all frequencies, resulting in a subsequent change in F1 and F2 during pitch-shifted trials. Researchers using this device should be mindful of stimuli selection to avoid confusion during data interpretation.
Drone detection and radar‐cross‐section measurements by RAD‐DAR
Authors: de Quevedo Álvaro Duque , Urzaiz Fernando Ibañez , Menoyo Javier Gismero , López Alberto Asensio 
Published: June 2019

RAD‐DAR is a frequency‐modulated‐continuous‐wave radar demonstrator, working at X‐band, completely designed and constructed by the authors’ research group following the ubiquitous‐radar concept. After introducing its main hardware and software blocks, with special emphasis to its off‐line signal processing and data processing, this study presents the results of a drone detection test, where RAD‐DAR achieved a DJI‐Phantom 4 detection and tracking at a range up to 3 km. The system performance is discussed with different flights including an attack manoeuvre, and a free flight, which helps to highlight their advantages in surveillance tasks due to the RAD‐DAR staring nature. Furthermore, range, speed and azimuth accuracies are discussed, considering the drone global positioning system data. Finally, this study shows a statistical radar cross‐section study based on the processed data of the drone and attempts to classify this target by means of Swerling models.
The use of anterior subcutaneous internal fixation (INFIX) for treatment of pelvic ring injuries in major trauma patients, complications and outcomes
Authors: Steer Richard , Balendra Ganesh , Matthews Justin , Wullschleger Martin , Reidy James 
Published: June 2019

Purpose: Pelvic anterior internal fixators (INFIX) are a relatively new alternative in the treatment of unstable pelvic fractures. The authors wanted to review the use of complications and outcomes of this method of pelvic fixation at our institution.
Method: Patients over the age of 18 who had an INFIX used in treatment of their pelvic ring injury were identified. Patient demographics, fracture type, injury severity score, morbidity, complications and time until removal were recorded. All available patients were followed up following the removal of the INFIX and completed an Iowa Pelvic Score (IPS) at this time.
Results and Discussion: 24 patients (19 male) with a mean age of 38.5 (range 18–71) met the inclusion criteria with an average injury severity score of 29.8 (10–66). The most common complication following insertion was a lateral femoral cutaneous nerve (LFCN) injury, which occurred in 11 patients (bilaterally in two), 6 patients (25%) had ongoing numbness 6 months post removal. Two patients had an infection, one of which prompted the removal of the INFIX. One INFIX was removed for implant failure. All other removals were planned electively. Heterotopic ossification was noted to have occurred in five cases. The mean IPS following removal of the INFIX was 79.2 (52–100). INFIX is a safe and successful treatment for unstable pelvic ring injuries. Overall, patients tolerate the INFIX well with good outcome scores. The main concern being the high rate of LFCN injuries, although many resolved after removal of the INFIX.
The clinical outcomes of total femur prosthesis in patients with musculoskeletal tumors
Authors: Kakimoto Takuya , Matsumine Akihiko , Asanuma Kunihiro , Matsubara Takao , Nakamura Tomoki , Sudo Akihiro 
Published: June 2019

Introduction:Reconstruction using a total femur prosthesis (TFP) remains a challenging procedure in musculoskeletal tumor surgery. The purpose of this study was to show the clinical outcomes of total femur replacement (TFR) in our institute.Methods:Nine patients underwent reconstruction with a TFP after the wide resection of malignant bone and soft-tissue tumors of the femur between January 2003 and April 2014. The mean age of the patients at the time of TFR was 47.5 years, and the mean follow-up period was 52.9 months. The histological diagnoses were as follows: bone sarcoma (n = 4), soft-tissue sarcoma invading the femoral bones (n = 4), and metastatic bone tumor (n = 1).Results: The oncological outcomes were as follows: three patients achieved continuous disease free, two patients were alive with disease, and four patients died from disease. The 3- and 5-year overall survival rates were 88.9% and 55.6%, respectively. The rate of the overall survival in patients with primary bone tumors (100% at 5 years) was significantly better than that in patients with primary soft tissue sarcomas (0% at 5 years) (p = 0.015). A deep infection occurred postoperatively in one patient, but the patient was successfully treated with surgical debridement and revision surgery. There were no patients who showed dislocation or aseptic loosening. The mean Musculo-Skeletal Tumor Society functional score was 58.5% (46.7–80.0), with scores of 65.5% in patients with a primary bone tumor and 50.8% in those with a primary soft-tissue sarcoma.Discussion: In the present study, the patients who underwent TFR due to bone invasion by soft tissue sarcoma had a worse prognosis than the bone sarcoma patients.
Kinder- und Jugendrheumatologie
Authors: Horneff Gerd 
Published: June 2019

Liebe Kolleginnen, liebe Kollegen,als Kinder- und Jugendrheumatologe war ich hocherfreut, die Aufforderung zu bekommen, eine ganze Ausgabe in dieser Zeitschrift kinder- und jugendrheumatologisch zu gestalten. Dabei war mir bewusst, dass diese Zeitschrift sich insbesondere an den praktisch tätigen Rheumatologen richtet. Die Auswahl der Themen wurde durch den Leitgedanken getrieben, Ihnen in der Arbeit mit Kindern und Jugendlichen eine bedeutsame Unterstützung zu bieten.
CGM-Parameter für das Diabetesmanagement – ein Update
Authors: Siegmund Thorsten , Kolassa Ralf , Thomas Andreas 
Published: June 2019

ZusammenfassungDas kontinuierliche Glukosemonitoring (CGM) liefert nicht nur ein lückenloses Glukoseprofil, sondern auch Parameter wie die Zeit im Zielbereich (TiR) oder die glykämische Variabilität, womit sich die Glykämie besser beschreiben und beurteilen lässt. Die wichtigsten Parameter wurden kürzlich in einem Konsensus-Statement definiert 1. In der vorliegenden Arbeit wird die Relevanz dieser CGM-Parameter beleuchtet und dargestellt, ob sich daraus Zusammenhänge zum HbA1c-Wert aufzeigen und das Risiko für die Entwicklung diabetischer Folgeerkrankungen ableiten lassen. Ob solche Zusammenhänge einfach kausal sind, also sich nur zwischen jeweils 2 Parametern ergeben, ist zu diskutieren. Vermutlich sind diese komplexer zueinander, so dass möglicherweise nur zusammengesetzte Metriken eine ausreichende Aussage zur Prognose ermöglichen. Weiterhin wird auf die ebenfalls in dem Konsensus-Statement angeregte Analyse von CGM-Daten mit dem AGP eingegangen.
Non-steroidal Anti-inflammatory Drugs in Tonic, Phasic and Inflammatory Mouse Models
Authors: Miranda Hugo F. , Noriega Viviana , Sierralta Fernando , Poblete Paula , Aranda Nicolas , Prieto Juan Carlos 
Published: June 2019

AbstractThe principal mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs) is the inhibition of ciclooxigenases. In this study was evaluated if NSAIDs could induce antinociceptive differences according to the type of murine pain model. Male mice were injected intraperitoneally with meloxicam, diclofenac, piroxicam, metamizol, ibuprofen, naproxen and paracetamol in the writhing, tail flick and formalin orofacial tests and dose-response were analyzed to obtain the ED50 of each drugs. Administration of NSAIDs produced in a dose-dependent antinociception with different potency in the tests. The relative potency of NSAIDs among the tests shows a value of 5.53 in the orofacial formalin test in phase I and 6.34 in phase II between meloxicam and paracetamol; of 7.60 in the writhing test between meloxicam and paracetamol and of 8.46 in the tail flick test between ibuprofen and paracetamol. If the comparison is made for each NSAID in the different tests, the minimum value was 0.01 for between writhing and phase II of the orofacial formalin. Meanwhile, the highest power ratio was 11.71 for diclofenac between writhing and tail flick tests. In conclusion, the results suggests that intraperitoneal NSAIDs administration induce antinociceptive activity depending on the type of pain. The results support that NSAIDs administration, induce a wide variety of antinociceptive effect, depending on the type of pain. This suggest the participation of different mechanisms of action that can be added to the simple inhibition of COXs controlled by NSAIDs.
Evolution of a Chemical Strategy Toward the Synthesis of Unsymmetrically Oxidized Nuphar Alkaloids
Authors: Lacharity Jacob J. , Zakarian Armen 
Published: June 2019

Here we describe the frustrations, joys, and unexpected turns experienced in our journey toward a successful strategy directed at the total synthesis of unsymmetrically oxidized Nuphar thioalkaloids. While many adjustments were made to our initial synthesis plan, our general approach to the construction of the central bis(spirothiolane) moiety remained unchanged. Specifically, each iteration of our synthesis design involved the formation of the thiaspirane motif through the stereodivergent coupling of a thietane with a metal carbenoid, followed by a Stevens-type rearrangement of the resulting sulfonium ylide.1	Introduction2	First-Generation Strategy3	Second-Generation Strategy4	Third-Generation Strategy5	Conclusion
Recaída bioquímica en cáncer de próstata de bajo riesgo tratados con prostatectomía radical y linfadenectomía pélvica
Authors: Varela Rodolfo , Céspedes Carlos , López de Mesa Byron , González Juanita , González Nataly 
Published: June 2019

Resumen
Objetivo La linfadenectomía pélvica ampliada es el método más confiable para identificar compromiso ganglionar en cáncer de próstata, sin embargo, la morbilidad, el tiempo quirúrgico, el papel terapéutico y las complicaciones, han sido temas de debate. El objetivo del estudio fue describir las características clínicas y patológicas de acuerdo con la presentación de recaída bioquimíca de los pacientes con cáncer de próstata de bajo riesgo tratados con prostatectomía radical más linfadenectomía pélvica ampliada.
Métodos Estudio descriptivo longitudinal retrospectivo en una cohorte de pacientes con cáncer de próstata de bajo riesgo tratados quirúrgicamente, entre enero 2006 hasta diciembre 2016. Se revisaron 210 historias clínicas, 178 cumplían los criterios de inclusión: PSA < 10 ng/mL; Gleason < 6, cT1–cT2a, revisión de las biopsias de próstata y procedimientos quirúrgicos realizados en la misma institución. Las variables a evaluar: porcentaje de compromiso tumoral, invasión linfovascular, concordancia de gleason, numero de ganglios resecados, ganglios positivos, densidad ganglionar, recaída bioquímica.
Resultados 178 pacientes con: 64 años, 62% T1c, psa de 6,37, compromiso de biopsia 23%. El 47% estaban subestadificados por gleason, con un promedio de ganglios resecados de 21, el compromiso ganglionar se encontró en un 3%, los bordes positivos en un 34% y la recaída bioquímica en un 19%. De los 33 pacientes con recaída bioquímica, el 6% tenían ganglios positivos y el 79% tenían bordes positivos, comparado con los que no recayeron: el 1% tenían ganglios positivos y el 23% eran R1, mientras que la invasión linfovascular solo estuvo presente en el 6% vs el 1% sin recaída. El tiempo a la recaída fue de 26 meses.
Conclusiones El compromiso ganglionar en cáncer de próstata es bajo, pero la subestadificación es alta. En el grupo de recaída bioquímica se observó que la mayoría de los pacientes presentaban bordes positivos y una subestadificacion del Gleason.
Lessons for Diabetes Care from Kahlil Gibran's The Prophet
Authors: Kalra Sanjay , Priya Gagan , Ruder Sundeep 
Published: June 2019

AbstractKhalil Gibran's book The Prophet (1923) shares the conversations of a preacher, Almustafa, as he prepares to leave the city of Orphalese, where he spent 12 years. A collection of prose poetry fables continues to inspire people from all walks of life and remains as relevant as when it was written. This opinion piece uses curated verses from The Prophet to highlight the relevance of Gibran's timeless wisdom to modern diabetes care. It attempts to extract core lessons and present in a contemporary way for a modern health care professional to effect on and use.
¿Qué factores se asocian con la reestrechez uretral en el paciente llevado a uretroplastia con o sin injerto?
Authors: Ramos Ana María , Ibáñez Diego Riatiga , Bolaños Andrea , Castillo Luisana , Zapata Carlos , Espinel Natalia Càrdenas 
Published: June 2019

Resumen
Objetivo Determinar los factores asociados a la reestrechez uretral en pacientes llevados a uretroplastia.
Métodos Estudio observacional analítico retrospectivo. Se revisaron las historias clínicas de pacientes llevados a uretroplastia en el HSJ entre 2012-2017. Se realizó un análisis bivariado para estudiar las asociaciones entre la reestrechez uretral posterior a la uretroplastia y las caracteristicas preoperatorias, intraoperatorias y posoperatorias, así como un modelo de regresión logística múltiple.
Resultados El total de pacientes llevados a uretroplastia fue de 82. La mediana de edad fue de 52 (RIQ = 35 -67) años. De todos los pacientes incluidos en el estudio 29 (36,2%) presentaron reestrechez. No se encontraron diferencias estadísticamente significativas en cuanto a los factores de riesgo en relación con reestrechez uretral en la población de estudio. Dentro de las técnicas quirúrgicas realizadas, los tipos de injerto utilizados en nuestros pacientes fueron la técnica con injerto de mucosa oral y con injerto de prepucio. De los pacientes a los cuales se les realizó uretroplastia con injerto de prepucio 13 (52%), presentaron reestrechez mostrando una diferencia estadísticamente significativa (p = 0,02). El tiempo quirúrgico fue mayor en los pacientes con reestrechez uretral (180 min RIQ = 120,0-189,0) comparado con los pacientes sin reestrechez (140 min RIQ = 120,0-198,0). En cuanto al modelo de regresión logística, pacientes llevados a uretroplastia con injerto de prepucio poseen más riesgo de presentar reestrechez uretral comparado con los pacientes a los cuales se les realizó la uretroplastia con otro tipo de injerto o con una tecnica terminoterminal sin injerto OR = 2,91 IC 95% (1,02-8,28).
Conclusiones En nuestro estudio solo se encontró que el tipo de injerto utilizado es el único factor asociado al desarrollo de reestrechez uretral posterior a la realización de uretroplastia, otras variables clínicas descritas en la literatura no tuvieron asociación en nuestro estudio.
Changes in Maximal Isometric Quadriceps Strength after the Application of Ultrasound-Guided Percutaneous Neuromodulation of the Femoral Nerve: A Case Series
Authors: Álvarez-Prats David , Carvajal-Fernández Óscar , Pérez-Mallada Néstor , Minaya-Muñoz Francisco 
Published: June 2019

Abstract
Introduction For those individuals who have suffered an injury to the knee or undergone a surgical intervention, the early recovery of the muscle strength contraction properties of the quadriceps is essential for a favorable recovery and for a return to the activities of daily living and other work- or sports-related activities.
Objectives To evaluate the changes in maximal isometric strength (MIS) of the quadriceps muscle after the application of ultrasound-guided percutaneous neuromodulation (US-guided PNM) on the femoral nerve.
Materials and Methods A case series involving subjects who had previously presented unilateral knee pathology and were in the stage of recovery of quadriceps strength. The subjects were pain-free at the time of the dynamometry measurements, which were performed before and after the application of the US-guided PNM technique. The isometric measurement was performed using the KINEO dynamometry system, performing a preintervention measurement of the mean maximal isometric strength (mMIS) based on 3 repetitions (3 seconds contraction and 6 seconds relaxation). The US-guided PNM technique was performed on the femoral nerve, using the Physio Invasiva CE0120 device (Prim Physio, Madrid, Spain) and a GE Logiq e R7 ultrasound (GE Healthcare, Chicago, IL, USA).
Results In total, 13 subjects participated in the present study. Significant changes were obtained (p < 0.001) in the mMIS of the quadriceps of the affected knee, which progressed from a mean strength of 25.91 kg (standard deviation [SD]: 7.17 kg) to a mean strength of 29.98 kg (SD: 9.06 kg).
Discussion In subjects with knee pathology, the quadriceps muscle is inhibited despite being pain-free during the strength measurements. This process of inhibition can improve with the application of low frequency percutaneous electrical stimulation on the femoral nerve. This technique represents a complementary strategy for the recovery of the normal strength values in pathological knees with or without prior surgery.
Conclusions Ultrasound-guided PNM is an effective technique for the reestablishment of quadriceps strength in inhibited muscles.
Cerclage Location and Gestational Age at Delivery
Authors: Estrada Fatima , Karakash Scarlett , SeeToe Terry , Weedon Jeremy , Minkoff Howard 
Published: June 2019

Objective Multiple authors have suggested cerclage position is a determinant of “success.” We assessed the interaction between cervical length (CL), cerclage height (cerH), proximal residual length (PRL), gestational age at delivery, and rate of delivery ≤ 34 weeks, in this study.
Study Design Present study is a retrospective cohort study of all cerclages placed at Maimonides Medical Center from 2006 to 2016. Outcomes: gestational age at delivery and delivery before 34 weeks; predictors: PRL, cerH, CL; and indications for cerclage: history (Hx), physical exam (PE), and ultrasound (US) indicated cerclage. A general linear model was used to predict power-transformed age at delivery from cerH, CL, and indication for cerclage. Subanalyses by indication were conducted. Logistic regression was used for delivery ≤ 34 weeks.
Results The cerH by indication did not reach statistical significance (p = 0.090). When stratified by indications, the effect of cerH on age at delivery was apparent for Hx (adjusted R
2 = 0.18, p < 0.001) and PE (adjusted R
2 = 0.43, p = 0.004) cerclages but not for US cerclages (adjusted R
2 = 0.08, p = 0.206). Logistic regression predicting delivery ≤ 34 weeks (n = 29) produced similar results.
Conclusions For Hx and PE indicated cerclages, the location of the stitch may influence the timing of delivery. Specifically, the higher the cerclage, the more advanced the gestational age at delivery.
New Approaches to Fetal Growth Restriction: The Time for Metabolomics Has Come
Authors: Leite Debora Farias Batista , Cecatti José Guilherme 
Published: June 2019

AbstractFetal growth restriction (FGR) diagnosis is often made by fetal biometric ultrasound measurements or Doppler evaluation, but most babies are only diagnosed after birth, using the birth weight as a proxy for intrauterine development. The higher risks of neurodevelopmental delay, metabolic syndrome, and cardiovascular illness associated with FGR impose a shift on the focus during pregnancy. New methodological approaches, like metabolomics, can provide novel biomarkers for intrauterine fetal development. Recent evidence on metabolites involved with fetal growth and weight show a consistent role played by lipids (especially fatty acids), amino acids, vitamin D and folic acid. Fetal energy source and metabolism, structural functions, and nervous system functioning need further evaluations in different populations. In the near future, the establishment of a core set of outcomes for FGR studies may improve the identification of the role of each metabolite in its development. Thus, we will concretely progress with the perspective of a translational capacity of metabolomics for this condition.
Can ReGeneraTing Agents Improve Functional Recovery of Transected Peripheral Nerve through a Nerve Gap Bridged with an Artery Graft?
Authors: Alexopoulos George , Pavlidis Leonidas , Tsagarakis Myron , Delimpaltas Alexandros , Tsimponis Antonios , Papalois Apostolos , Batistatou Anna , Papoudou-Bai Alexandra , Barritault Denis , Demiri Efterpi , Spyropoulou Georgia Alexandra 
Published: June 2019

Background The purpose of this study was to use artery grafts filled with CACIPLIQ20 and see if they promote nerve regeneration.
Methods Sixty male Wistar rats were used. The rats were randomly divided into four experimental groups (n = 15): transected control group (negative control group [NCG]), sham-operated group (positive control group [SO]) artery graft group filled with saline (AG/NS), and CACIPLIQ20-treated group (AG/CACIPLIQ20). Fifteen rats were used as artery graft donors. In the SO group, the sciatic nerve was dissected from the surrounding tissues and left intact. In the NCG, AG/NS and AG/CACIPLIQ20) groups, a 10-mm gap was created in the left sciatic nerve. In the NCG group, the gap was not bridged with a graft. In the AG/NS group, the gap was bridged with a graft filled with saline. In the AG/CACIPLIQ20 group, the graft was filled with CACIPLIQ20. Walking track analysis was performed at 4, 8, 12, and 16 weeks after surgery. At 16 weeks postoperatively, the rats were sacrificed, nerve sections were harvested for histopathology analysis, and the weight ratio of the gastrocnemius muscle was measured.
Results There was no significant difference in myelin sheath thickness between the AG/NS and AG/CACIPLIQ20 groups. Muscle weight in the AG/CACIPLIQ20 group was higher but not statistically significant (p = 0.168) compared with the AG/NS group. Also, AG/CACIPLIQ20 mean was better than AG/NS mean, although there was no statistically significant difference (p = 0.605).
Conclusion There could be an indication that CACIPLIQ20 improves functional recovery of a transected peripheral nerve through a nerve gap bridged with an artery graft.
Ensuring Effective Communication in the Diabetes Clinic: Creating a Curve of Remembering
Authors: Lathia Tejal 
Published: June 2019

AbstractPatient–doctor interview involves exchange of information. Often, consultation may be hurried in resource-constrained settings whereby large quantity of health-related information is delivered to patient in a short period of time. Most people quickly forget what they have heard only once, thus putting into doubt how much of what patients are told, is really comprehended, recalled and thus, acted on. Repeating information, information delivery in staggered format, as well as the use of media for reinforcement helps patients comprehend and recall information better.