bluuebunny/crossref_metadata_2025_split huggingface dataset:
A physics-based approach of deep interseismic creep for viscoelastic strike-slip earthquake cycle models
Authors: Bruhat Lucile 
Published: September 2019

SUMMARYMost geodetic inversions of surface deformation rates consider the depth distribution of interseismic fault slip-rate to be time invariant. However, some numerical simulations show downdip penetration of dynamic rupture into regions with velocity-strengthening friction, with subsequent updip propagation of the locked-to-creeping transition. Recently, Bruhat and Segall developed a new method to characterize interseismic slip rates, that allows slip to penetrate up dip into the locked region. This simple model considered deep interseismic slip as a crack loaded at its downdip end, and provided analytical expressions for stress drop within the crack, slip and slip rate along the fault. This study extends this approach to strike-slip fault environments, and includes coupling of creep to viscoelastic flow in the lower crust and upper mantle. I use this model to investigate interseismic deformation rates along the Carrizo Plain section of the San Andreas fault. This study reviews possible models, elastic and viscoelastic, for fitting horizontal surface rates. Using this updated approach, I develop a physics-based solution for deep interseismic creep which accounts for possible slow vertical propagation, and investigate how it improves the fit of the horizontal deformation rates in the Carrizo Plain region. I found solutions for fitting the surface deformation rates that allow for reasonable estimates for earthquake rupture depth and coseismic displacement and improves the overall fit to the data. Best-fitting solutions present half-space relaxation time around 70 yr, and very low propagation speeds, less than a metre per year, suggesting a lack of creep propagation.
Social enterprises’ impact on older people’s health and wellbeing: exploring Scottish experiences
Authors: Henderson Fiona , Steiner Artur , Mazzei Micaela , Docherty Catherine 
Published: September 2019

Abstract
The global aging demographic is putting pressure on state-delivered health and social care services. As the austerity agenda in the UK cuts state-funded service provision for older people despite increasing demand, social enterprise has become a politically and economically attractive model for the sustainable delivery of some public services. Yet little is known about the impact of social enterprise on the health and wellbeing of older people. In this paper we address this gap in understanding and consider social enterprise activities as complex public health-promoting interventions. Our study aimed to understand what impact social enterprise activities had on the health and wellbeing of participants aged over 50, and also how that impact was created. To achieve this, we conducted qualitative semi-structured interviews with a sample (n = 43) of staff, volunteers, clients and carers aged over 50 who were involved in activities delivered by three social enterprises. Using a thematic analysis to explore manifest and latent themes, two antecedents of subjective younger age emerged explaining how benefit was created, namely downward social comparison and identity. The social enterprise activities we studied benefited participants' health and wellbeing, impacting positively on participants' sense of purpose, social support, connectedness and inclusion. These health and wellbeing benefits can be considered as outcomes of complex public health interventions for older people, and we relate these outcomes to beneficial conditions within the intermediary social determinants of health. We conclude by discussing the future impact of social enterprise activities and current UK policy on the structural determinants of health.
Pulmonary artery cannulation to enhance extracorporeal membrane oxygenation management in acute cardiac failure
Authors: Lorusso Roberto , Raffa Giuseppe Maria , Heuts Samuel , Lo Coco Valeria , Meani Paolo , Natour Ehsan , Bidar Elham , Delnoij Thijs , Loforte Antonio 
Published: September 2019

Abstract

OBJECTIVES
Pulmonary artery (PA) cannulation during peripheral venoarterial extracorporeal membrane oxygenation (ECMO) has been shown to be effective either for indirect left ventricular (LV) unloading or to allow right ventricular (RV) bypass with associated gas-exchange support in case of acute RV with respiratory failure. This case series reports the results of such peculiar ECMO configurations with PA cannulation in different clinical conditions.

METHODS
All consecutive patients receiving PA cannulation (direct or percutaneous) from January 2015 to September 2018 in 3 institutions were retrospectively reviewed. Isolated LV unloading or RV support, as well as dynamic support including initial drainage followed by perfusion through the PA cannula, was used as part of the ECMO configuration according to the type of patient and the patient’s haemodynamic/functional needs.

RESULTS
Fifteen patients (8 men, age range 45–73 years, EuroSCORE log range 14.45–91.60%) affected by acute LV, RV or biventricular failure of various aetiologies, were supported by this ECMO mode. Percutaneous PA cannulation was performed in 10 patients and direct PA cannulation, in 5 cases. Dynamic ECMO management (initially draining and then perfusing through the PA cannula) was carried out in 6 patients. Mean ECMO duration was 9.1 days (range 6–17 days). One patient exhibited pericardial fluid during the implant of a PA cannula (no lesion found when the chest was opened), and weaning from temporary circulatory support was achieved in 14 patients (1 who received a transplant). Three patients (20%) died in-hospital, and 12 patients were successfully discharged without major complications.

CONCLUSIONS
Effective indirect LV unloading in peripheral venoarterial ECMO as well as isolated RV support can be achieved by PA cannulation. Such an ECMO configuration may allow the counteraction of common venoarterial ECMO shortcomings or allow dynamic/adjustable management of ECMO according to specific ventricular dysfunction and haemodynamic needs. Percutaneous PA cannulation was shown to be safe and feasible without major complications. Additional investigation is needed to confirm the safety and efficacy of such an ECMO configuration and management in a larger patient population.
Investigating associations between rural-to-urban migration and cardiometabolic disease in Malawi: a population-level study
Authors: Chilunga Felix P , Musicha Crispin , Tafatatha Terence , Geis Steffen , Nyirenda Moffat J , Crampin Amelia C , Price Alison J 
Published: September 2019

Abstract

Background
The extent to which rural-to-urban migration affects risk for cardiometabolic diseases (CMD) in Africa is not well understood. We investigated prevalence and risk for obesity, diabetes, hypertension and precursor conditions by migration status.

Methods
In a cross-sectional survey in Malawi (February 2013–March 2017), 13 903 rural, 9929 rural-to-urban migrant and 6741 urban residents (≥18 years old) participated. We interviewed participants, measured blood pressure and collected anthropometric data and fasting blood samples to estimate population prevalences and odds ratios, using negative binomial regression, for CMD, by migration status. In a sub-cohort of 131 rural–urban siblings-sets, migration-associated CMD risk was explored using conditional Poisson regression.

Results
In rural, rural-to-urban migrant and urban residents, prevalence estimates were; 8.9, 20.9 and 15.2% in men and 25.4, 43.9 and 39.3% in women for overweight/obesity; 1.4, 2.9 and 1.9% in men and 1.5, 2.8 and 1.7% in women for diabetes; and 13.4, 18.8 and 12.2% in men and 13.7, 15.8 and 10.2% in women for hypertension. Rural-to-urban migrants had the greatest risk for hypertension (adjusted relative risk for men 1.18; 95% confidence interval 1.04–1.34 and women 1.17: 95% confidence interval 1.05–1.29) and were the most screened, diagnosed and treated for CMD, compared with urban residents. Within sibling sets, rural-to-urban migrant siblings had a higher risk for overweight and pre-hypertension, with no evidence for differences by duration of stay.

Conclusions
Rural-to-urban migration is associated with increased CMD risk in Malawi. In a poor country experiencing rapid urbanization, interventions for the prevention and management of CMD, which reach migrant populations, are needed.
Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project
Authors: Ranzani Otavio T , Milà Carles , Sanchez Margaux , Bhogadi Santhi , Kulkarni Bharati , Balakrishnan Kalpana , Sambandam Sankar , Sunyer Jordi , Marshall Julian D , Kinra Sanjay , Tonne Cathryn 
Published: September 2019

Abstract

Background
Evidence linking ambient air pollution with atherosclerosis is lacking from low- and middle-income countries. Additionally, evidence regarding the association between household air pollution and atherosclerosis is limited. We evaluated the association between ambient fine particulate matter [particulate matter with an aerodynamic diameter of ≤2.5 µm (PM2.5)] and biomass fuel use on carotid intima-media thickness (CIMT), a surrogate of atherosclerosis, in India.

Methods
We analysed the third follow-up of the Andhra Pradesh Children and Parent Study cohort (2010–2012), which recruited participants from 28 peri-urban villages. Our primary outcome was mean CIMT, measured using a standardized protocol. We estimated annual average PM2.5 outdoors at residence using land-use regression. Biomass cooking fuel was self-reported. We fitted a within-between linear-mixed model adjusting for potential confounders.

Results
Among 3278 participants (48% women, mean age 38 years), mean PM2.5 was 32.7 [range 24.4–38.2] µg/m3, and 60% used biomass. After confounder adjustment, we observed positive associations between within-village variation in PM2.5 and CIMT in all participants [1.79%, 95% confidence interval (CI), −0.31 to 3.90 per 1  µg/m3 of PM2.5] and in men (2.98%, 95% CI, 0.23–5.72, per 1  µg/m3 of PM2.5). Use of biomass cooking fuel was associated with CIMT in all participants (1.60%, 95% CI, −0.46 to 3.65), especially in women with an unvented stove (6.14%, 95% CI, 1.40–10.89). The point-estimate for the PM2.5 association was larger in sub-groups with higher cardiometabolic risk profile.

Conclusions
Ambient and household air pollution were positively associated with CIMT in a peri-urban population of India, although with limited precision for some estimates. We observed differences in the association between ambient and household air pollution and CIMT by gender.
Internal Politics and the Fragmentation of Armed Groups
Authors: Perkoski Evan 
Published: September 2019

AbstractArmed groups are prone to instability and fragmentation, but what explains variation among the new groups that emerge? I argue that the internal politics preceding organizational splits is critical. When it comes to the survival of breakaway groups, those forming around single issue areas gain an advantage by attracting more homogeneous, preference-aligned recruits. On the other hand, those forming over a variety of grievances attract a more heterogeneous population whose divergent views undermine cohesion and cooperation, necessitate hierarchy, and diminish the odds of organizational survival. I test this argument with a case study of two Republican groups from Northern Ireland—the Real Irish Republican Army and the Irish National Liberation Army. The findings confirm my argument and underscore the limited utility of studying organizational fractures from the sole perspective of contemporaneous external events like conciliation and repression. Rather, I show how internal political dynamics influence the composition, identity, and overall trajectory of breakaway groups. This has implications for designing effective counterinsurgent policies, for understanding the formation of armed groups, and for anticipating whether breakaway groups are likely to escalate, moderate, or adopt spoiling behavior.
Safety concerns with consumer-facing mobile health applications and their consequences: a scoping review
Authors: Akbar Saba , Coiera, Enrico , Magrabi Farah 
Published: September 2019

AbstractObjectiveTo summarize the research literature about safety concerns with consumer-facing health apps and their consequences.Materials and MethodsWe searched bibliographic databases including PubMed, Web of Science, Scopus, and Cochrane libraries from January 2013 to May 2019 for articles about health apps. Descriptive information about safety concerns and consequences were extracted and classified into natural categories. The review was conducted in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) statement.ResultsOf the 74 studies identified, the majority were reviews of a single or a group of similar apps (n = 66, 89%), nearly half related to disease management (n = 34, 46%). A total of 80 safety concerns were identified, 67 related to the quality of information presented including incorrect or incomplete information, variation in content, and incorrect or inappropriate response to consumer needs. The remaining 13 related to app functionality including gaps in features, lack of validation for user input, delayed processing, failure to respond to health dangers, and faulty alarms. Of the 52 reports of actual or potential consequences, 5 had potential for patient harm. We also identified 66 reports about gaps in app development, including the lack of expert involvement, poor evidence base, and poor validation.ConclusionsSafety of apps is an emerging public health issue. The available evidence shows that apps pose clinical risks to consumers. Involvement of consumers, regulators, and healthcare professionals in development and testing can improve quality. Additionally, mandatory reporting of safety concerns is needed to improve outcomes.
Effect of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation to lactating sows on growth and indicators of stress in the postweaned pig12
Authors: McAfee John M , Kattesh Henry G , Lindemann Merlin D , Voy Brynn H , Kojima Cheryl J , Burdick Sanchez Nicole C , Carroll Jeff A , Gillespie Barbara E , Saxton Arnold M 
Published: September 2019

Abstract
Dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) are precursors for lipid metabolites that reduce inflammation. Two experiments were conducted to test the hypothesis that enriching the sow diet in n-3 PUFA during late gestation and throughout lactation reduces stress and inflammation and promotes growth in weaned pigs. A protected fish oil product (PFO; Gromega) was used to enrich the diet in n-3 PUFA. In the initial experiment, time-bred gilts were fed a gestation and lactation diet supplemented with 0% (control; n = 5), 0.25% (n = 4), 0.5% (n = 4), or 1% (n = 5) PFO from 101 ± 2 d of gestation to day 16 of lactation. Adding 1% PFO to the diet increased the n-3:n-6 PUFA ratio in colostrum and milk compared with controls (P = 0.05). A subsequent experiment was performed to determine whether supplementing the sow diet with 1% PFO improved growth and reduced circulating markers of acute inflammation and stress in the offspring. Plasma was harvested from piglets (16 per treatment group) on day 0 (d of weaning) and days 1 and 3 postweaning. Pigs from the 1% PFO treatment group weighed more (P = 0.03) on day 3 postweaning and had a greater (P ˂ 0.05) n-3:n-6 PUFA ratio in plasma on each day sampled compared with 0% PFO controls. There was an overall treatment effect on plasma total cortisol (P = 0.03) and haptoglobin (P = 0.04), with lesser concentrations in pigs on the 1% PFO diet. Plasma corticosteroid-binding globulin (CBG) concentrations were not different between treatment groups but were less (P ˂ 0.001) on days 1 and 3 when compared with day 0. The resultant free cortisol index [FCI (cortisol/CBG)] was less (P = 0.02) on days 1 and 3 for pigs from the 1% treatment group compared with the controls. An ex vivo lipopolysaccharide (LPS) challenge of whole blood collected on days 0 and 1 was used to determine whether 1% PFO attenuated release of inflammatory cytokines (IL-1β, IL-6, and TNF-α). Blood from pigs within the 1% PFO treatment group tended (P = 0.098) to have a lesser mean concentration of TNF-α in response to LPS compared with blood from controls. These results suggest that providing a PFO supplement as 1% of the diet to sows beginning in late gestation and during lactation can increase the n-3:n-6 PUFA ratio in their offspring, which may improve growth and reduce the acute physiological stress response in the pigs postweaning.
Chemical toolbox for ‘live’ biochemistry to understand enzymatic functions in living systems
Authors: Komatsu Toru , Urano Yasuteru 
Published: September 2019

Abstract
In this review, we present an overview of the recent advances in chemical toolboxes that are used to provide insights into ‘live’ protein functions in living systems. Protein functions are mediated by various factors inside of cells, such as protein−protein interactions, posttranslational modifications, and they are also subject to environmental factors such as pH, redox states and crowding conditions. Obtaining a true understanding of protein functions in living systems is therefore a considerably difficult task. Recent advances in research tools have allowed us to consider ‘live’ biochemistry as a valid approach to precisely understand how proteins function in a live cell context.
Resistance of rice genotypes to Tibraca limbativentris (Hemiptera: Pentatomidae)
Authors: De S Almeida André Cirilo , Dierings Cássio A , Borella Júnior Celio , Jesus Flávio G , Barrigossi Jose A F 
Published: September 2019

AbstractThe Tibraca limbativentris is a pest that causes rice crop damage and may lead to grain yield reductions of up to 90%. The most commonly used tactic for T. limbativentris control is chemical, which causes adverse effects on the environment. This study was conducted to identify sources of antixenosis and antibiosis resistance to T. limbativentris mediated by the hardness and diameter of the stem of the rice plant. Antibiosis and antixenosis tests were carried out with 22 rice genotypes of Brazilian and Asian origin. The Canela de Ferro, BRS Esmeralda, and Desconhecido Branco genotypes had the lowest proportions of stems showing symptoms of the damage caused by T. limbativentris. Canela de Ferro, Primavera, and IR 22 genotypes had the lowest nymphs survivorship and the genotypes Marabá Branco, Marabá, Skirivimankoti, Pepita, BR IRGA 409, Curinga, IR 40, Bonança, Desconhecido Branco, Bico Ganga, Primavera, and BRS Esmeralda were the least attractive to the insects. The genotypes BRS Esmeralda, Primavera, Desconhecido Branco, and Canela de Ferro were resistant to the rice stalk stink bug by antibiosis and/or antixenosis. These genotypes can be used directly by rice farmers for T. limbativentris management. Molecular biology studies should be conducted to identify and characterize resistance genes in these genotypes so that they can be used in breeding programs.
Isolation and Characterization of Microsatellite Markers for Soybean Looper (Lepidoptera: Noctuidae)
Authors: Silva C S , Cordeiro E M G , Corrêa A S 
Published: September 2019

AbstractWe constructed 13 microsatellite markers for Chrysodeixis includens (Walker), a serious crop pest in the Americas. All SSR (Simple Sequence Repeat) markers were polymorphic, with no evidence of linkage disequilibrium between any loci in any population. The total number of alleles per locus ranged from 5 for L3, L9, and L11 to 26 for L6; the mean number of alleles per locus in three populations of C. includens ranged from 2.33 for L3 to 14.67 for L6. Hardy–Weinberg equilibrium (HWE) deviation was not observed in four loci for at least one population (L3, L5, L9, L10). Markers L6, L7, L8, L10, L11, L12, and L13 showed a frequency of null alleles &gt; 0.2 for at least one population. STRUCTURE and F-statistics revealed low population structure among the populations (FST = 0.013) and a high degree of inbreeding (FIS = 0.658). The SSR markers developed here will be useful in future studies on the ecology, demography, host dynamics, and gene flow of C. includens. This information is essential to understand the recent status of C. includens as a key pest in South America.
Male and female bats differ in their use of a large urban park
Authors: Patriquin Krista J , Guy Cylita , Hinds Joshua , Ratcliffe John M 
Published: September 2019

AbstractUnderstanding how wildlife respond to ever-encroaching urbanization is of great concern. Bats are the second-most speciose mammalian order and while many appear to be urban adapted, we currently have a limited understanding of their demography and habitat use within urban environments. Using a combination of captures to obtain demographic data, radio-telemetry to examine foraging and roosting behaviour, and data on diet and prey availability, we examined how big brown bats (Eptesicus fuscus), a synurbic species, use an urban green space (High Park) in Canada’s largest city centre, Toronto. We found that adult males outnumbered adult females more than two to one and that males were found throughout the park, while females were concentrated in an area with greater access to water, but lower prey availability. We also found that bats of both sexes were in poorer body condition than reported for other non-urban areas, including a site within southern Ontario. Our data suggest that High Park may not provide adequate resources for reproductive females as they were never found roosting in the park and beetles, their preferred prey, were limited. Although previous studies suggest urban green spaces may offer refuge to bats, most have not considered sex-specific responses to urbanization as they have largely been based on acoustic surveys. Our study therefore highlights the importance of considering demographic differences in response to urbanization to better inform urban management plans and green space development.
STAT5: From Pathogenesis Mechanism to Therapeutic Approach in Acute Leukemia
Authors: Shahjahani Mohammad , Abroun Amirreza , Saki Najmaldin , Bagher Mohammadi Seyed Mohammad , Rezaeeyan Hadi 
Published: September 2019

Abstract

Background
Based on the results of multiple studies, multiple signaling pathways is a major cause of resistence to chemotherapy in leukemia cells. Signal transducer and activator of transcription 5 (STAT5) is among these factors; it plays an essential role in proliferation of leukemic cells.

Methods
We obtained the materials used in our study via PubMed search from 1996 through 2019. The key search terms included “STAT5,” “acute leukemia,” “leukemogenesis,” and “mutation.”

Results
On activation, STAT5 not only inhibits apoptosis of leukemic cells via activating the B-cell lymphoma 2 (BCL-2) gene but also inhibits resistance to chemotherapy by enhancing human telomerase reverse transcriptase (hTERT) expression and maintaining telomere length in cells. It has also been shown that a number of mutations in the STAT5 gene and in related genes alter the expression of STAT5.

Conclusion
The identification of STAT5 and the factors activated in its up- or downstream expression, affecting its function, contribute to better treatments such as targeted therapy rather than chemotherapy, improving the quality of life patients.