bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of Tai Chi and Baduanjin on breast cancer patients: systematic review and meta-analysis of randomized controlled trials
Authors: Chen Yifang , Zuo Xinyi , Tang Yong , Zhou Zhimiao 
Published: October 2024

BackgroundTai Chi and Baduanjin are nonpharmacological interventions that are widely applied among cancer patients.ObjectiveThis meta-analysis aimed to assess the effect of Tai Chi and Baduanjin on breast cancer patients by summarizing and pooling the results of previous studies.MethodsThe PubMed, Embase, Web of Science, Scopus and Cochrane Library and several databases were searched up to December 1, 2023, to identify high-quality RCTs. Relevant terms such as Tai Chi and Baduanjin were used as keywords. Stata 15.0 software and Review Manager (version 5.3; Cochrane Training) were used to screen the studies, extract the data, code the data, and perform the meta-analysis. The mean differences (MDs) and standardized mean differences (SMDs) with 95% CIs were used to calculate continuous variables. The Cochrane risk of bias assessment tool was used to evaluate the risk of bias. The PICOS framework was used to develop the following eligibility criteria: (i) population - breast cancer patients; (ii) intervention - Tai Chi and Baduanjin intervention; (iii) comparison - Tai Chi and Baduanjin group and different intervention (e.g., regular intervention, routine rehabilitation training, waiting list, sham Qigong, usual care, no intervention); (iv) outcomes - cognitive ability, shoulder joint function, anxiety, depression, fatigue, sleep quality, quality of life; and (v) study design - randomized controlled trial.ResultsFrom January 2013 to December 2023, we included a total of 16 RCTs involving 1247 patients. A total of 647 patients were in the experimental group and were treated with Tai Chi and Baduanjin, while 600 patients were in the control group and were treated with traditional methods. The results of our meta-analysis indicate that Tai Chi and Baduanjin yield outcomes that are comparable to those of traditional treatment methods. Specifically, Tai Chi and Baduanjin significantly increased cognitive function, increased shoulder joint function, improved sleep quality indicators and improved quality of life indicators. Furthermore, Tai Chi and Baduanjin significantly reduced anxiety symptoms, depression symptoms, and fatigue symptoms among breast cancer patients. Sensitivity analysis was performed, a funnel plot was constructed. No publication bias was indicated by Egger’s or Begg’s test.ConclusionOverall, Tai Chi and Baduanjin are viable and effective nonpharmacological approaches for treating breast cancer patients, as they yield better results than traditional treatment methods. However, these findings should be interpreted with caution due to the limited number of controlled trials, small sample sizes, and low quality of the evidence.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023469301.
Association between surgery treatment delays and survival outcomes in patients with esophageal cancer in Hebei, China
Authors: Cui Xing , Shi Chunxiao , Chen Xin , Zhao Qi , Zhao Jidong 
Published: October 2024

IntroductionThe delays in cancer therapies have the potential to impact disease progression by allowing the unchecked growth and spread of cancer cells. However, the understanding of the association between treatment waiting time and survival outcomes in patients with esophageal cancer (EC) is limited. This study aims to assess the impact of waiting time on survival outcomes among EC patients in Hebei province, which is recognized as one of the high-risk areas for EC in China.MethodsA total of 9,977 non-metastatic EC patients who underwent surgical treatment were identified between 2000 and 2020. The survival outcomes of overall survival (OS) and cancer-specific survival (CSS) were determined using the Kaplan-Meier methodology. Univariate and multivariate Cox regression analysis was employed to evaluate the impact of treatment delays on OS and CSS.ResultsThe average delay time for initiating EC surgical treatment after diagnosis was 1.31 months (95%CI=1.29–1.34). Patients with a long delay (≥ 3 months) in treatment, comprising 9977 EC patients, exhibited significantly lower rates of 3-, 5-, and 10-year OS and CSS compared to those without any delay in treatment initiation. A long delay in EC treatment independently associated with an elevated risk of all-cause and cancer-cause mortality among various patient subgroups, including males, older individuals, single individuals, low-income patients, residents of nonmetropolitan counties, as well as those diagnosed with poorly differentiated and stage IV EC.DiscussionThe long delay of treatment initiation impacts the outcomes of OS and CSS in EC patients. Optimizing treatment timing may enhance life expectancy for individuals diagnosed with EC.
Virulence perspective genomic research unlocks the secrets of Rhizoctonia solani associated with banded sheath blight in Barnyard Millet (Echinochloa frumentacea)
Authors: Patro T. S. S. K. , Palanna K. B. , Jeevan B. , Tatineni Pallavi , Poonacha T. Tharana , Khan Farooq , Ramesh G. V. , Nayak Anusha M. , Praveen Boda , Divya M. , Anuradha N. , Rani Y. Sandhya , Nagaraja T. E. , Madhusudhana R. , Satyavathi C. Tara , Prasanna S. Koti 
Published: October 2024

IntroductionBanded sheath blight (Bsb) disease, caused by Rhizoctonia solani, is an emerging problem in barnyard millet cultivation. One of the significant goals of pathogenomic research is to identify genes responsible for pathogenicity in the fungus.MethodsA virulence profiling-based approach was employed and six R. solani isolates were collected from various ecological zones of India. The morphological parameters and virulence of all of the six R. solani isolates were investigated. The most virulent strain was designated as RAP2 and its genome has been sequenced, assembled, and annotated.ResultsThe RAP2 genome is 43.63 megabases in size and comprises 10.95% repetitive DNA, within which 46% are retroelements, 8% are DNA transposons, and 46% are unidentified DNA. The Gene Ontology (GO) annotation of RAP2 proteins revealed that “phosphorylation”, “membrane”, and “ATP binding” have the highest gene enrichment in the “biological process”, “cellular component” and “molecular function” domains, respectively. The genome comprises a majority of secretory proteins in the pectin lyase fold/virulence factor superfamily, which break down plant cell wall polymers to extract saccharides. The RAP2 genome is comparable to R. solani, which infects maize and rice, but it diverges further from soybean in terms of nucleotide-level genetic similarity. Orthologous clustering of RAP2 protein sequences with R. solani infecting maize, rice, and soybean yields 5606 proteins shared across all genomes. GO analysis of 25 proteins specific to the RAP2 genome found enrichment in the ethylene response, which can cause spore germination and infection in host plants.DiscussionInterestingly, a 28-bp deletion in the RAP2 strain’s cutinase domain was discovered in the cutinase protein, which might be important in the infection process, perhaps rendering the enzyme inactive or allowing the pathogen to infect barnyard millet while avoiding host defense. This study sheds light on the genetic makeup of R. solani, allowing researchers to discover critical genes related with pathogenicity as well as potential targets for fungicide development.
Social health gradient and risk factors among patients hospitalized for COVID-19 and pre-pandemic respiratory infections. A linked national individual case-control study in Belgium
Authors: Bruyneel Arnaud , Dauvergne Jérôme E. , Dauby Nicolas , Goffard Jean-Christophe , Rea Andrea , Racape Judith 
Published: October 2024

IntroductionThe literature establishes a clear social gradient in health for transmissible respiratory diseases. However, this gradient’s extent remains largely unexplored in the context of COVID-19, and it is uncertain whether the pandemic has exacerbated this gradient. The study aims to compare the socio-economic profiles and comorbidities during the COVID-19 pandemic with a control population affected by viral pneumonia/respiratory disease in 2019.MethodsThis case-control study analyzed linked data from all patients hospitalized for COVID-19 in 2020 (n = 22,087) and for respiratory diseases in 2019 (n = 7,586). Socio-economic data from the social security database were linked to clinical data from the hospital registry. We analyzed the socio-demographic and clinical factors associated with COVID-19 hospitalization (control group, wave 1, and wave 2) using multinomial regressions and logistic regression models and the length of stay during hospitalization using binomial negative regressions.ResultsA social health gradient was observed in both the COVID-19 and control groups, with a significant increase across waves for COVID-19 (p-trend &lt; 0.0001). Men, people over the age of 45, those with comorbidities, high population density, lower income, lower socio-economic status, and people living in Brussels capital were at higher risk of COVID-19 hospitalization and longer length of stay compared to the control group. Except for sub-Saharan Africans, all patients of foreign nationality had a significantly increased risk of hospitalization (p &lt; 0.001), but a shorter length of stay compared to Belgians.ConclusionThe socio-health gradient for COVID-19 followed the same pattern as that observed in pre-pandemic respiratory diseases, intensifying in the second wave and among the most deprived groups. This study emphasizes the importance of collecting social data alongside clinical data for a better understanding of social health inequalities and for tailoring health prevention policies.
Acquaintance, attitude, and perceived barriers regarding scientific research publications among clinical nurses: a cross-sectional study at tertiary care hospitals in western Rajasthan
Authors: Kalal Nipin , Vel N. sabari , Chaudhary Saroj , Meena Savita , Meena Sonam , Bhichar Sonu , Singh Spraha 
Published: October 2024

IntroductionIn today's era, conducting nursing research is crucial for the advancement of the nursing profession. Scientific publications in clinical research aim to improve patient care outcomes and foster a sense of importance for nurses within the healthcare team. However, clinical nurses often fall behind due to factors such as limited familiarity, attitudes toward research, and encountered barriers.ObjectivesThis study was conducted to assess the knowledge, attitude, and perceived barriers regarding scientific research publications among clinical nurses at tertiary care hospitals in western Rajasthan.MethodologyA cross-sectional descriptive study was conducted among the clinical nurses. The participants were assessed for their knowledge, attitude, and perceived barriers regarding scientific research publications through a self-administered questionnaire.ResultsThe study revealed that 92% of the participants lacked sufficient knowledge about scientific research publications and 78.3% experienced moderate perceived barriers. Pearson's correlation coefficient indicated a weak positive correlation (r = 0.143, p = 0.007) between knowledge and attitude and a significant negative correlation (r = −0.143, p = 0.012) between knowledge and perceived barriers. However, multiple linear regression analysis showed no significant relationship among the clinical nurses in terms of knowledge, attitude, and perceived barriers toward scientific research publications.ConclusionThis study on clinical nurses revealed that the majority had insufficient knowledge about scientific research, while over half had neutral attitudes toward research publications. In addition, a significant portion of the clinical nurses reported experiencing moderate perceived barriers.
Stress Can Induce Bovine Alpha-Herpesvirus 1 (BoHV-1) Reactivation from Latency
Authors: El-Mayet Fouad , Jones Clinton 
Published: October 2024

Bovine alpha-herpesvirus 1 (BoHV-1) is a significant problem for the cattle industry, in part because the virus establishes latency, and stressful stimuli increase the incidence of reactivation from latency. Sensory neurons in trigeminal ganglia and unknown cells in pharyngeal tonsils are importantsites for latency. Reactivation from latency can lead to reproductive problems in pregnant cows, virus transmission to young calves, suppression of immune responses, and bacterial pneumonia. BoHV-1 is also a significant cofactor in bovine respiratory disease (BRD). Stress, as mimicked by the synthetic corticosteroid dexamethasone, reproducibly initiates reactivation from latency. Stress-mediated activation of the glucocorticoid receptor (GR) stimulates viral replication and transactivation of viral promoters that drive the expression of infected cell protein 0 (bICP0) and bICP4. Notably, GR and Krüppel-like factor 15 (KLF15) form a feed-forward transcription loop that cooperatively transactivates immediate early transcription unit 1 (IEtu1 promoter). Two pioneer transcription factors, GR and KLF4, cooperatively transactivate the bICP0 early promoter. Pioneer transcription factors bind silent viral heterochromatin, remodel chromatin, and activate gene expression. Thus, wepredict that these novel transcription factors mediate early stages of BoHV-1 reactivation from latency.
Implementation of Artificial Intelligence on Personnel Management in a Dynamic Society
Authors: Edwin Edwin Ihechituru , Ogbonna Ugwu Chibuike Chris , Obumnaeme Ilo Kingsley 
Published: October 2024

The bedrock of this study is Implementation of Artificial Intelligence (AI) on Personnel Management in a Dynamic Society.. The rapid development and advancement of the digital environment, the increase in computing power, the processing of huge amounts of data and advanced algorithms have not only made AI exceptional and indispensable, but also emerged as a key tool in talent management. Methodologically, the study used secondary data collection sources such as textbooks, magazines, newspapers, journals, and periodical reports. The study found, among other things, that the development of AI leads to errors caused by machines due to programming errors and persistence of discrimination/preferential treatment in recruitment. Therefore, AI is not able to recognize corporate culture and values when evaluating applicants. The paper recommends that companies should focus on updating and training their current employees to avoid job losses due to the emergence of AI and adapt to the current framework conditions, etc. Thus, the paper concludes that the increasing use of AI will have a social and economic impact in this millennium, as it aims at digitalization and development by utilizing AI-inspired decision-making and integrating advanced information systems into multidimensional areas of activity, with a significant impact on various sectors around the world.
ОСТРАЯ ЛЕКАРСТВЕННАЯ ТОКСИКОДЕРМИЯ У РЕБЕНКА РАННЕГО ВОЗРАСТА. КЛИНИЧЕСКИЙ СЛУЧАЙ.
Authors: Л.М. Ахметова , Х.Т. Тохтар , К.Д. Стыбаев 
Published: October 2024

Лекарственная токсикодермия чаще всего проявляется как результат длительного введения медикамента и представляет собой вариант лекарственной болезни. Описанный клинический случай демонстрирует лекарственную токсическую реакцию на антибиотик цефалоспоринового ряда. Показывает тяжесть заболевания, динамику нарастания симптомов, течение клинической картины. В последние десятилетия широкое и повсеместное применение различных групп лекарственных препаратов привело к высокому распространению лекарственных токсидермий у детей разных возрастов. Особенно данная проблема актуальна в настоящее время, когда на фармацевтическом рынке преобладает широкий и доступный выбор различных препаратов, в том числе и антибактериальных. Данные, приведенные в статье, будут полезны педиатрам, аллергологам и врачам общей практики.
Drug toxicoderma most often manifests itself as a result of prolonged administration of the drug and is a variant of the drug disease. The described clinical case demonstrates a drug toxic reaction to a cephalosporin antibiotic. Shows the severity of the disease, the dynamics of the increase in symptoms, the course of the clinical picture. In recent decades, the widespread and widespread use of various groups of drugs has led to a high prevalence of drug toxidermia in children of different ages. This problem is especially relevant at the present time, when the pharmaceutical market is dominated by a wide and affordable choice of various drugs, including antibacterial ones. The data presented in the article will be useful to pediatricians, allergists and general practitioners.
Дәрілік токсикодермия көбінесе препаратты ұзақ уақыт қабылдау нәтижесінде көрінеді және есірткі ауруының нұсқасы болып табылады. Сипатталған клиникалық жағдай цефалоспориндік антибиотикке дәрілік токсикалық реакцияны көрсетеді. Аурудың ауырлығын, симптомдардың күшею динамикасын, клиникалық көріністің ағымын көрсетеді. Соңғы онжылдықтарда әртүрлі топтағы препараттарды кеңінен және кеңінен қолдану әртүрлі жастағы балаларда есірткі токсидермиясының жоғары таралуына әкелді. Бұл мәселе әсіресе фармацевтикалық нарықта әртүрлі дәрі-дәрмектердің, соның ішінде бактерияға қарсы препараттардың кең және қолжетімді таңдауы басым болған қазіргі уақытта өзекті болып табылады. Мақалада келтірілген деректер педиатрларға, аллергологтарға және жалпы тәжірибелік дәрігерлерге пайдалы болады.
Melestarikan Permainan Tradisional Engklek Kepada Generasi Z
Authors: Rahman Fadhillah Irsyad , Adjie Fathurrazzaq , Lumiu Immanuel , Siahaya Shintya Bellia , Dewi R. Retna Kinanti , Gemael Qorry Armen 
Published: October 2024

Seiring perkembangan zaman, kemajuan teknologi dan informasi memberi dampak yang luar biasa bagi kehidupan manusia. Mulai dari aspek ekonomi, pendidikan, budaya hidup, dan lain sebagainya, termasuk juga dalam segi hiburan. Indonesia terkenal dengan berbagai macam kebudayaan dan sejarahnya. Namun seiring perkembangan zaman, banyak generasi muda dan anak anak sudah mulai meninggalkan budaya yang menurut mereka kuno dan beralih ke budaya modern. Hiburan adalah aspek yang paling menonjol dalam perkembangan teknologi ini. Anak anak zaman sekarang lebih cenderung terpacu menjadi dengan gamers online dari pada mengenenal warisan tradisionalnya sendiri. Hal ini dapat menimbulkan rasa asing di generasi penerus, padahal itu adalah kekayaan warisan mereka sendiri yang sudah ada sebelum mereka lahir. Salah satu solusi yang bisa ditawarkan adalah dengan sosialisasi permainan olahraga tradisional. Tujuan sosialisasi ini untuk memberikan edukasi dan memperkenalkan kembali macam macam olahraga tradisional yang sudah mulai ditinggalkan seiring dengan perkembangan zaman yang semakin canggih sehingga berakibat pada memudarnya rasa memiliki suatu peninggalan yang bersejarah bagi para generasi masa kini. Kegiatan ini akan di sosialisasikan kepada anak anak akademi basket Pelita Jaya Karawang. Metode sosialisasi yang digunakan adalah metode sosialisasi formal. Jenis olahraga tradisional yang akan di sosialisasi kan adalah engklek

Abstract : Along with the times, advances in technology and information have had a tremendous impact on human life. Starting from the economic aspect, education, culture of life, and so on, including also in terms of entertainment. Indonesia is famous for its various cultures and history. However, along with the development of the times, many young people and children have begun to leave the culture they think is ancient and switch to modern culture. Entertainment is the most prominent aspect in the development of this technology. Today's children are more likely to be stoked with online gamers than to get to know their own traditional heritage. This can create a feeling of alienation in the next generation, even though it is their own inherited wealth that existed before they were born. One solution that can be offered is the socialization of traditional sports games. The purpose of this socialization is to provide education and reintroduce various types of traditional sports which have begun to be abandoned along with increasingly sophisticated developments, resulting in a waning sense of belonging to a historic heritage for today's generations. This activity will be socialized to the children of the Pelita Jaya Karawang basketball academy. The socialization method used is the formal socialization method. The type of traditional sport that will be socialized is the engklek sport.
Penyuluhan Kesehatan Cegah Obesitas dengan Pola Makan dan Gaya Hidup Sehat
Authors: Badriyah Lulu’ul 
Published: October 2024

Obesitas menjadi tantangan besar masalah kesehatan masyarakat global yang terkait dengan peningkatan risiko penyaki. Provinsi DKI Jakarta menempati urutan kedua provinsi dengan 29,8% penduduk usia ≥18 tahun yang mengalami obesitas. Maka dari itu, perlunya edukasi tentang pencegahan obesitas dengan gaya hidup dan pola makan sehat. Secara garis besar kegiatan pengabdian masyarakat meliputi kegiatan penyuluhan dan pemeriksaan status gizi dan kesehatan. Adapun materi yang disampaikan dalam penyuluhan meliputi pengertian obesitas, pengukuran obesitas, klasifikasi obesitas, jenis obesitas, dan cara pencegahan obesitas dengan hidup sehat. Hasil pemeriksaan status gizi menunjukkan sebagian besar peserta mengalami obesitas dan obesitas sentral. Kegiatan ini dilaksanakan di RW 04 Kelurahan Lenteng Agung Jakarta Selatan pada Kamis, 9 Maret 2023 dari jam 09.00-12.00 WIB. Kegiatan ini diikuti oleh 24 orang
Pelaksanaan Kegiatan Pengelolaan Posyandu Melati II Bersama Kader Posyandu Di Desa Rengasdengklok Utara Kecamatan Rengasdengklok Kabupaten Karawang
Authors: Setiawati Riska , Wariah Uway , Yanti Irma 
Published: October 2024

Posyandu merupakan salah satu bentuk Upaya Kesehatan Bersumber Daya Masyarakat (UKBM) yang dikelola dan diselenggarakan dari, oleh, untuk, dan bersama masyarakat dalam penyelenggaraan pembangunan kesehatan, guna memberdayakan masyarakat dan memberikan kemudahan kepada masyarakat dalam memperoleh pelayanan kesehatan dasar untuk mempercepat penurunan angka kematian ibu, bayi, dan balita. Tujuan pengabdian masyarakat ini diharapkan dapat meningkatkan peran serta dalam mensukseskankegiatan yang berdaya masyarakat tersebut dan dapat menambah wawasan pengetahuan untuk selalu memberikan kontribusi kepada masyarakat. Peran kader dalam penyelenggaraan posyandu sangat besar karena selain sebagai pemberi informasi kesehatan kepada masyarakat untuk datang ke posyandu dan melaksanakan perilaku hidup bersih dan sehat. Ibu hamil yang hadir pada saat kegiatan Posyandu adalah 11 orang dan bayi balita sejumlah 84 orang. Hasil kegiatan pengabdian masyarakat ini sangat memberikan dampak yang positif dan kegiatan lima meja dapat terlaksana dengan baik serta kader yang berperan aktif sangat antusias dalam membantu pelayanan tenaga kesehatan.