bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between serum level of advanced glycation end products and obstructive sleep apnea–hypopnea syndrome: a meta-analysis
Authors: Wu Xingyu , She Wensheng , Niu Xun , Chen Xiong 
Published: September 2018

Objective This meta-analysis was performed to assess the difference in the serum level of advanced glycation end products (AGEs) between patients with obstructive sleep apnea–hypopnea syndrome (OSAHS) and controls. Methods A systematic literature search was performed using PubMed, Elsevier, SCI, Wanfang, Weipu, and China National Knowledge Internet. Eligible studies that reported the serum AGE level in patients with OSAHS were identified by two reviewers. Review Manager version 5.2 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) and R version 3.10 ( www.r-project.org ) were employed for data synthesis. Results Five studies involving 670 subjects were identified. The meta-analysis showed that the mean serum AGE level in the OSAHS group was 0.98 mmol/L higher than those in the control group (95% confidence interval, 0.69–1.27). Conclusions This meta-analysis showed that the serum AGE level was elevated in patients with OSAHS. This finding suggests that AGEs may play an important role in insulin resistance in OSAHS and serve as a biomarker for patients with OSAHS with a high risk of type 2 diabetes mellitus.
The use of antiplatelet agents after an acute coronary syndrome in a large community Italian setting of more than 12 million subjects
Authors: Maggioni Aldo P , Dondi Letizia , Pedrini Antonella , Ronconi Giulia , Calabria Silvia , Cimminiello Claudio , Martini Nello 
Published: September 2018

Background: Antiplatelet agents are the cornerstone of medical treatment in acute coronary syndromes. The aim of this study was to evaluate the clinical epidemiology of patients after an acute coronary syndrome treated with different antiplatelet agent regimens in a large real community setting. Methods: The ARCO database, including more than 12 million inhabitants, was evaluated. Antiplatelet agent prescriptions were analysed as follows: aspirin, clopidogrel, other antiplatelet agents used alone; the free and fixed combination of clopidogrel and aspirin; the free combination of aspirin with other antiplatelet agents. Healthcare costs included drug prescriptions (prices reimbursed by the Italian National Health System), outpatient specialist services and hospitalisations (Italian national tariffs). Results: From 1 January to 31 December 2014, 26,834 patients were discharged after an acute coronary syndrome. Of these, 19,333 (77%) were prescribed with an antiplatelet agent. Among patients undergoing a revascularisation procedure either percutaneous or surgical (47% of the total population), antiplatelet agents were prescribed in 90% of cases. Dual antiplatelet agent therapy was prescribed in 49.6% of the total population and in 68.5% of those treated invasively. Prescription continuity was observed in just 75% of patients. The highest adherence was observed for the fixed combination of aspirin/clopidogrel (81.5%). Throughout one year of follow-up re-hospitalisation occurred in 47.9% of the patients and the direct cost per patient treated with an antiplatelet agent was €13,297 versus €16,647 in patients not treated with antiplatelet agents. Conclusions: This study highlights that antiplatelet agent prescriptions, specifically dual antiplatelet agent therapy, are at least suboptimal as well as in prescription continuity. Hospitalisations were frequent and were the main driver of the costs, accounting for 84% of the total costs for the Italian National Health System.
A mutation of the human EPHB2 gene leads to a major platelet functional defect
Authors: Berrou Eliane , Soukaseum Christelle , Favier Rémi , Adam Frédéric , Elaib Ziane , Kauskot Alexandre , Bordet Jean-Claude , Ballerini Paola , Loyau Stephane , Feng Miao , Dias Karine , Muheidli Abbas , Girault Stephane , Nurden Alan T. , Turro Ernest , Ouwehand Willem H. , Denis Cécile V. , Jandrot-Perrus Martine , Rosa Jean-Philippe , Nurden Paquita , Bryckaert Marijke 
Published: September 2018

Abstract
The ephrin transmembrane receptor family of tyrosine kinases is involved in platelet function. We report the first EPHB2 variant affecting platelets in 2 siblings (P1 and P2) from a consanguineous family with recurrent bleeding and normal platelet counts. Whole-exome sequencing identified a c.2233C&gt;T variant (missense p.R745C) of the EPHB2 gene. P1 and P2 were homozygous for this variant, while their asymptomatic parents were heterozygous. The p.R745C variant within the tyrosine kinase domain was associated with defects in platelet aggregation, αIIbβ3 activation, and granule secretion induced by G-protein–coupled receptor (GPCR) agonists and convulxin, as well as in thrombus formation on collagen under flow. In contrast, clot retraction, flow-dependent platelet adhesion, and spreading on fibrinogen were only mildly affected, indicating limited effects on αIIbβ3 outside-in signaling. Most importantly, Lyn, Syk, and FcRγ phosphorylation, the initial steps in glycoprotein VI (GPVI) platelet signaling were drastically impaired in the absence of platelet–platelet contact, indicating a positive role for EPHB2 in GPVI activation. Likewise platelet activation by PAR4-AP showed defective Src activation, as opposed to normal protein kinase C activity and Ca2+ mobilization. Overexpression of wild-type and R745C EPHB2 variant in RBL-2H3 (rat basophilic leukemia) cells stably expressing human GPVI confirmed that EPHB2 R745C mutation impaired EPHB2 autophosphorylation but had no effect on ephrin ligand-induced EPHB2 clustering, suggesting it did not interfere with EPHB2-ephrin–mediated cell-to-cell contact. In conclusion, this novel inherited platelet disorder affecting EPHB2 demonstrates this tyrosine kinase receptor plays an important role in platelet function through crosstalk with GPVI and GPCR signaling.
National Cancer Institute Breast Cancer Steering Committee Working Group Report on Meaningful and Appropriate End Points for Clinical Trials in Metastatic Breast Cancer
Authors: Seidman Andrew D. , Bordeleau Louise , Fehrenbacher Louis , Barlow William E. , Perlmutter Jane , Rubinstein Lawrence , Wedam Suparna B. , Hershman Dawn L. , Hayes Jennifer Fallas , Butler Lynn Pearson , Smith Mary Lou , Regan Meredith M. , Beaver Julia A. , Amiri-Kordestani Laleh , Rastogi Priya , Zujewski Jo Anne , Korde Larissa A. 
Published: September 2018

Purpose To provide evidence-based consensus recommendations on choice of end points for clinical trials in metastatic breast cancer, with a focus on biologic subtype and line of therapy. Methods The National Cancer Institute Breast Cancer Steering Committee convened a working group of breast medical oncologists, patient advocates, biostatisticians, and liaisons from the Food and Drug Administration to conduct a detailed curated systematic review of the literature, including original reports, reviews, and meta-analyses, to determine the current landscape of therapeutic options, recent clinical trial data, and natural history of four biologic subtypes of breast cancer. Ongoing clinical trials for metastatic breast cancer in each subtype also were reviewed from ClinicalTrials.gov for planned primary end points. External input was obtained from the pharmaceutic/biotechnology industry, real-world clinical data specialists, experts in quality of life and patient-reported outcomes, and combined metrics for assessing magnitude of clinical benefit. Results The literature search yielded 146 publications to inform the recommendations from the working group. Conclusion Recommendations for appropriate end points for metastatic breast cancer clinical trials focus on biologic subtype and line of therapy and the magnitude of absolute and relative gains that would represent meaningful clinical benefit.
Circulating Human Papillomavirus DNA as a Biomarker of Response in Patients With Locally Advanced Cervical Cancer Treated With Definitive Chemoradiation
Authors: Han Kathy , Leung Eric , Barbera Lisa , Barnes Elizabeth , Croke Jennifer , Di Grappa Marco A. , Fyles Anthony , Metser Ur , Milosevic Michael , Pintilie Melania , Wolfson Robert , Zhao Zhen , Bratman Scott V. 
Published: September 2018

Purpose To determine whether plasma human papillomavirus (HPV) DNA predates clinical recurrence and compare its accuracy with 3-month fluorodeoxyglucose positron emission tomography (FDG-PET) in locally advanced cervical cancer. Methods This prospective multicenter study accrued 23 women with stage IB to IVA cervical cancer planned for definitive chemoradiation therapy (CRT). Plasma HPV DNA was measured serially by digital polymerase chain reaction, and FDG-PET was performed at 3 months post-CRT. Results Of the 19 women with HPV+ cervical cancer included in this analysis, 32% were stage IB, 58% IIB, and 10% IIIB/IVA. Median follow-up was 24 months (range, 18 to 30 months). All patients had detectable plasma HPV DNA before treatment. Six patients had detectable plasma HPV DNA at the end of CRT, and three of them developed metastases at 3 months. Of the 13 patients with undetectable plasma HPV DNA at end of CRT, to date, only one has developed recurrence. Six of those 13 patients had a positive 3-month FDG-PET with no definite residual disease on subsequent imaging or clinical examination to date, and four of these six had undetectable plasma HPV DNA at 3 months. Patients with undetectable plasma HPV DNA at end of CRT had significantly higher 18-month progression-free survival than those with detectable plasma HPV DNA (92% v 50%; P = .02). The area under the receiver operating characteristic curve (accuracy) of 3-month plasma HPV DNA and 3-month FDG-PET imaging for predicting recurrence at 18 months were 77% and 60%, respectively ( P = .008). Conclusion Detectable plasma HPV DNA at end of CRT predates the clinical diagnosis of metastases and is associated with inferior progression-free survival. Moreover, 3-month plasma HPV DNA level is more accurate than 3-month FDG-PET imaging in detecting residual disease. The clinical utility of plasma HPV DNA detection for guiding adjuvant/salvage therapy should be evaluated in future studies.
Effect of androgen deprivation and radiation therapy on MRI fiber tractography in prostate cancer: can we assess treatment response on imaging?
Authors: Hedgire Sandeep , Kilcoyne Aoife , Tonyushkin Alexey , Mao Yun , Uyeda Jennifer W , Gervais Debra A , Harisinghani Mukesh G 
Published: September 2018

Objective:
To evaluate quantitative changes in Diffusion Tensor Magnetic Resonance Tractography in prostate cancer following androgen deprivation and radiation therapy.

Methods:
22 patients with elevated PSA and biopsy proven prostate carcinoma who underwent MRI of the prostate at 1.5 T with an endorectal coil were included. Group A) was the study group (n = 11), participants who underwent androgen deprivation and/or radiation therapy and group B) were Gleason-matched control group (n = 11) participants who did not undergo such therapy. Diffusion weighted images were used to generate three-dimensional (3D) map of fiber tracts from DTI. 3D regions of interest (ROI) were drawn over the tumor and healthy prostatic parenchyma in both groups to record tract number and tract density. Tumor region and normal parenchymal tract densities within each group were compared.

Results:
Mean tract density in the tumor region and normal parenchyma was 2.3 and 3.3 in study group (tract numbers: 116.6 and 170.2 respectively) and 1.6 and 2.7 in the control group respectively (tract numbers: 252.5 and 346.3 respectively). The difference between these values was statistically significant for the control group (p = 0.0018) but not for the study group (p = 0.11). The difference between the tract numbers of tumor and normal parenchyma appears to narrow following therapy.

Conclusion:
The study demonstrated utility in using tractography as a biomarker in prostate cancer patients post treatment.

Advances in knowledge:
Quantitative DTI fiber tractography is a promising imaging biomarker to quantitatively assess treatment response in the setting of post-androgen deprivation and radiation therapy for prostate cancer.
The Adoption of an Online Journal Club to Improve Research Dissemination and Social Media Engagement Among Hospitalists
Authors: Wray Charlie M. , Auerbach Andrew D. , Arora Vineet M. 
Published: September 2018

BACKGROUNDTwitter‐based journal clubs are intended to connect clinicians, educators, and researchers to discuss recent research and aid in dissemination of results. The Journal of Hospital Medicine (JHM) began producing a Twitter‐based journal club, #JHMChat, in 2015.OBJECTIVETo describe the implementation and assess the impact of a journal‐sponsored, Twitter‐based journal club on Twitter and journal metrics.INTERVENTIONEach #JHMChat focused on a recently published JHM article, was moderated by a social media editor, and included one study author or guest.MEASUREMENTSThe total number of participants, tweets, tweets/participant, impressions, page views, and change in the Altmetric score were assessed after each session. Thematic analysis of each article was conducted, and post‐chat surveys of participating authors and participant responses to continuing medical education surveys were reviewed.RESULTSSeventeen Twitter‐based chats were held: seven (47%) focused on value, six (40%) targeted clinical issues, and four (27%) focused on education. On average, we found 2.17 (±0.583 SD) million impressions/session, 499 (±129 SD) total tweets/session, and 73 (±24 SD) participants/session. Value‐based care articles had the greatest number of impressions (2.61 ± 0.55 million) and participants (90 ± 12). The mean increase in the Altmetric score was 14 points (±12), with medical education‐themed articles garnering the greatest change (mean increase of 32). Page views were noted to have increased similarly to levels of electronic Table of Content releases. Authors and participants believed #JHMChat was a valuable experience and rated it highly on post‐chat evaluations.CONCLUSIONOnline journal clubs appear to increase awareness and uptake of journal article results and are considered a useful tool by participants.
Endothelin-1 Measurement in Patients Undergoing Diagnostic Coronary Angiography—Results from the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) Study
Authors: Ibrahim Nasrien E , Gupta Rajat , Lyass Asya , Li Yiwei , Shrestha Shreya , McCarthy Cian P , Gaggin Hanna K , van Kimmenade Roland R J , Massaro Joseph M , D'Agostino Ralph B , Januzzi James L 
Published: September 2018

Abstract

BACKGROUND
Endothelin-1 (ET-1) is a vasoconstrictor produced by vascular endothelial cells and may play a role in risk for development of coronary artery disease (CAD) and heart failure (HF). In a cohort of 1084 patients referred for coronary angiography, we investigated cross-sectional associations between ET-1 concentrations and prevalent CAD, as well as value of ET-1 for prognostication of future cardiovascular events.

METHODS
Associations between ET-1 and presence/severity of CAD were assessed. Patients were followed for a median of 4 years for outcomes including incident HF, myocardial infarction (MI), cardiovascular mortality, and all-cause mortality.

RESULTS
The median concentration of ET-1 was 2.57 ng/L. Patients with ET-1 concentrations above the median were more likely to have higher risk clinical features. Among those without prevalent MI at presentation, ET-1 concentrations were not associated with presence or severity of CAD. In adjusted Cox proportional hazards analyses, log-transformed ET-1 concentrations predicted incident HF [hazard ratio (HR) = 1.51 per increase in log-SD; 95% CI, 1.06–2.15; P = 0.02] and all-cause mortality (HR = 1.61 per increase in log-SD; 95% CI, 1.03–2.53; P = 0.04). Concentrations of ET-1 above the median were associated with shorter time to incident HF, MI, cardiovascular mortality, all-cause mortality, and the composite of incident HF/MI/cardiovascular mortality (all log-rank P &lt; 0.001).

CONCLUSIONS
Despite epidemiologic links to CAD, we found no cross-sectional association between biologically active ET-1 and prevalent coronary atherosclerosis in an at-risk population referred for coronary angiography. Increased ET-1 concentrations independently predict incident HF and death and are associated with more near-term cardiovascular events.
METODE SYARAḤ AL-SUYŪṬĪ DALAM AL-DĪBĀJ: Kritik terhadap Syaraḥ Hadis Penafsiran Surah al-Mā’idah Ayat 3 dan Perbandingannya dengan Syaraḥ al-Nawawī
Authors: Faza Asrar Mabrur 
Published: September 2018

This article studies about syaraḥ hadith method used by al-Suyūṭī in his al-Dībāj where he had developed eight forms of syaraḥ within this kitab, those are Ḍabṭ al-alfāẓ, tafsīr al-garīb, bayān ikhtilāf riwāyāt alā al-qillah, ziyādah fī khabr lam tarid lahu ṭarīquhu, tasmīyah al-mubham, i‘rāb al-musykil, jam‘u baina al-mukhtalaf, as well īḍāh mubham. This study entails when Al-Suyūṭī applied those eight forms of syaraḥ in tafsir surah al-Mā’idah ayat 3 was paradoxically inconsistent. He modestly used tafsīr al-garīb and bayān ikhtilāf riwāyāt alā al-qillah, while at the same time benefited linguistic, normative-theology, historicity as approach as well as respected a syaraḥ writing method called qauluhu. In order to equivocate from plagiarizing al-Minhāj, this paper views that al-Suyūṭī intentionally had furthered his work with ijmālī method. This is how he judiciously amazed his reader.
“Barzanji Bugis” dalam Peringatan Maulid: Studi Living Hadis di Masyarakat Bugis, Soppeng, Sul-Sel
Authors: Muttaqin Ahmad 
Published: September 2018

Prior to reading this paper, it is important to realize that hadis as source of islamic teachings has been expressed on cultural varieties. This aims to explore how the Bugis society views both the meaning of Maulid (prophetic birthday celebration) and the reading of Bugis-barzanji and to analyze the acculturation between both islamic teaching and Bugis culture on reading the Barzanji in Maulid. This research uses acculturational concept to explore deeply and briefly how islamic teaching and local tradition produce the new religious cultural practices. This concludes that first, barzanji in Bugis society is one of religious cultural practices regarded as secred tradition excepting in Maulid. Second, the Bugis-barzanji read on maulid celebration in order that society are able to understand easily the barzanji containing sīrah nabawiyyah (prophetic history) is one of living-hadis phenomena.
Ragam Makna Kesahihan Hadis
Authors: Azhari Ainul Azhari , ‘Ulama`i A. Hasan Asy’ari , Musyafiq Ahmad Musyafiq 
Published: September 2018

The scholars of hadith have standards and criteria for determining the validity of the hadith. Therefore, their standards vary and through the different criteria are different in interpreting the authentic hadith. This difference of meaning must be explained in relation to the practice of hadith and its use as an argument. The true meaning according to Muhammad Haqqi al-Nāzilī is a continuous hadith, not narrated through the siqah narrator, in spite of syaż and 'illat and his traditions conveying the privileges of the sunna practices that can motivate someone to carry out the practices of the sunna. So someone who performs these deeds based on authentic hadith and get a reward that doubled because it already knows the virtue of the hadith.The validity of the traditions contained in the book of Khazīnat al-Asrār Jalīlat al-Ażkār based on the criteria of the jumhur ulama of hadith states that these traditions do not reach the valid degree. But the traditions in it are dominated by hadith hasan and ḍa'īf. From a number of hadiths sampled in this study proves that there are 14 Hadiths, Hadiths that have ḍa'if degree of hadith 24 hadith, and hadith reaching degree ṣaḥīḥ only 8 hadith. However, according to al-Nāzili hadith in the book of Khazīnat al-Asrār are authentic hadiths based on the standard of criteria that he possesses. Para ulama hadis mempunyai standar dan kriteria untuk menentukan kesahihan hadis. Maka dari itu, standar mereka berbeda-beda dan melalui perbedaan kriteria tersebut maka berbeda pula dalam memaknai hadis sahih. Perbedaan makna ini harus dijelaskan terkait dengan pengamalan hadis dan penggunaannya sebagai hujah. Makna sahih menurut Muhammad Haqqi al-Nāzilī adalah hadis yang sanadnya bersambung, tidak diriwayatkan melalui perawi yang ṡiqah, tidak terhindar dari syaż dan ‘illat dan hadis-hadisnya menyampaikan keistimewaan dari amalan-amalan sunah yang dapat memotivasi seseorang untuk melaksanakan amalan-amalan sunah. Sehingga seseorang yang melaksanakan amalan-amalan tersebut berdasarkan hadis sahih dan mendapatkan pahala yang berlipat ganda karena sudah mengetahui keutamaannya dari hadis tersebut. Kesahihan hadis yang terdapat dalam kitab Khazīnat al-Asrār Jalīlat al-Ażkār berdasarkan standar kriteria jumhur ulama hadis menyatakan bahwa hadis-hadis tersebut tidak mencapai derajat sahih. Melainkan hadis-hadis di dalamnya didominasi oleh hadis hasan dan ḍa’īf. Dari sejumlah hadis yang dijadikan sampel dalam penelitian ini membuktikan bahwa hadis yang berderajat hasan ada 14 hadis, hadis yang berderajat ḍa’if ada hadis 24 hadis, dan hadis yang mencapai derajat ṣaḥīḥ hanya 8 hadis. Tetapi, menurut al-Nāzili hadis dalam kitab Khazīnat al-Asrār merupakan hadis-hadis sahih berdasarkan standar kriteria yang ia miliki.
Particular Forms of Management of Agro – Industrial Complex in the Sustainable Development of Agriculture
Authors: AIMURZINA Baglan , KAMENOVA Mazken , OMAROVA Ainura , PESTUNOVA Galina , KARIPOVA Ainur , MADENOVA Kulshara 
Published: September 2018

In this paper it is noted that the important problem of the existing economic relations in the agrarian sphere is the choice of forms of management. The practice of reforms in agriculture has shown that more than 80% of gross output in Kazakhstan is currently produced by "households" and peasant (farmer) farms which provides further increase in the production of agricultural products namely crop production and increase its economic efficiency. Currently the agricultural sector has a tendency to small-scale production. As the situation has shown one of the main factors negatively influencing investment activity is financial instability of the majority of agricultural producers, low level of its profitability and significant risks. Factors of low profit growth of the agricultural sector are related to the peculiarities of demand for agricultural products and seasonality of production in this industry.
The analysis of the structure of gross agricultural production of the Republic of Kazakhstan by categories of farms, the returnability of agricultural production for 2012-2016 shows the impact of the price and yield of grain on the level of farm income. Proposals for further improvement of grain pricing are given.