bluuebunny/crossref_metadata_2025_split huggingface dataset:
xGASS: The impact of photometric bulges on the scatter of HI scaling relations
Authors: Cook Robin H W , Cortese Luca , Catinella Barbara , Robotham Aaron 
Published: October 2019

ABSTRACT
We present a structural decomposition analysis of the galaxies in the extended GALEX Arecibo SDSS Survey (xGASS) using (gri) images from the Sloan Digital Sky Survey. Utilizing the 2D Bayesian light profile fitting code ProFit, we fit single- and double-component models taking advantage of a robust Markov chain Monte Carlo optimization algorithm in which we assume a Sérsic profile for single-component models and a combination of a Sérsic bulge and near-exponential disc (0.5 ≤ n ≤ 1.5) for double-component models. We investigate the effect of bulges on the atomic hydrogen (H i) content in galaxies by revisiting the H i-to-stellar mass scaling relations with the bulge-to-total ratio measured in the ProFit decompositions. We show that, at both fixed total and disc stellar mass, more bulge-dominated galaxies have systematically lower H i masses, implying that bulge-dominated galaxies with large H i reservoirs are rare in the local Universe. We see similar trends when separating galaxies by a bulge-to-total ratio based either on luminosity or stellar mass, however, the trends are more evident with luminosity. Importantly, when controlling for both stellar mass and star formation rate, the separation of atomic gas content reduces to within 0.3 dex between galaxies of different bulge-to-total ratios. Our findings suggest that the presence of a photometric bulge has little effect on the global H i gas reservoirs of local galaxies.
The extended main-sequence turn-off of the Milky Way open cluster Collinder 347
Authors: Piatti Andrés E , Bonatto Charles 
Published: October 2019

ABSTRACT
We made use of the Gaia DR2 archive to comprehensively study the Milky Way open cluster Collinder 347, known until now as a very young object of solar metal content. However, the G versus GBP − GRP colour–magnitude diagram (CMD) of bonafide probable cluster members, selected on the basis of individual stellar proper motions, their spatial distribution, and placement in the CMD, reveals the existence of a Hyades-like age open cluster (log(t /yr) = 8.8) of moderately metal-poor chemical content ([Fe/H] = −0.4 dex), with a present-day mass of 3.3 × 103 M⊙. The cluster exhibits an extended main-sequence turn-off (eMSTO) of nearly 500 Myr, while that computed assuming Gaussian distributions from photometric errors, stellar binarity, rotation, and metallicity spread yields an eMSTO of ∼340 Myr. Such an age difference points to the existence within the cluster of stellar populations with different ages.
The contribution of Centaur-emitted dust to the interplanetary dust distribution
Authors: Poppe A R 
Published: October 2019

ABSTRACT
Interplanetary dust grains originate from a variety of source bodies, including comets, asteroids, and Edgeworth–Kuiper belt objects. Centaurs, generally defined as those objects with orbits that cross the outer planets, have occasionally been observed to exhibit cometary-like outgassing at distances beyond Jupiter, implying that they may be an important source of dust grains in the outer Solar system. Here, we use an interplanetary dust grain dynamics model to study the behaviour and equilibrium distribution of Centaur-emitted interplanetary dust grains. We focus on the five Centaurs with the highest current mass-loss rates: 29P/Schwassmann-Wachmann 1, 166P/2001 T4, 174P/Echeclus, C/2001 M10, and P/2004 A1, which together comprise 98 per cent of the current mass loss from all Centaurs. Our simulations show that Centaur-emitted dust grains with radii s < 2 μm have median lifetimes consistent with Poynting–Robertson (P–R) drag lifetimes, while grains with radii s > 2 μm have median lifetimes much shorter than their P–R drag lifetimes, suggesting that dynamical interactions with the outer planets are effective in scattering larger grains, in analogy to the relatively short lifetimes of Centaurs themselves. Equilibrium density distributions of grains emitted from specific Centaurs show a variety of structure including local maxima in the outer Solar system and azimuthal asymmetries, depending on the orbital elements of the parent Centaur. Finally, we compare the total Centaur interplanetary dust density to dust produced from Edgeworth–Kuiper belt objects, Jupiter-family comets, and Oort cloud comets, and conclude that Centaur-emitted dust may be an important component between 5 and 15 au, contributing approximately 25 per cent of the local interplanetary dust density at Saturn.
Identifying microbial species by single-molecule DNA optical mapping and resampling statistics
Authors: Bouwens Arno , Deen Jochem , Vitale Raffaele , D’Huys Laurens , Goyvaerts Vince , Descloux Adrien , Borrenberghs Doortje , Grussmayer Kristin , Lukes Tomas , Camacho Rafael , Su Jia , Ruckebusch Cyril , Lasser Theo , Van De Ville Dimitri , Hofkens Johan , Radenovic Aleksandra , Frans Janssen Kris Pieter 
Published: October 2019

Abstract
Single-molecule DNA mapping has the potential to serve as a powerful complement to high-throughput sequencing in metagenomic analysis. Offering longer read lengths and forgoing the need for complex library preparation and amplification, mapping stands to provide an unbiased view into the composition of complex viromes and/or microbiomes. To fully enable mapping-based metagenomics, sensitivity and specificity of DNA map analysis and identification need to be improved. Using detailed simulations and experimental data, we first demonstrate how fluorescence imaging of surface stretched, sequence specifically labeled DNA fragments can yield highly sensitive identification of targets. Second, a new analysis technique is introduced to increase specificity of the analysis, allowing even closely related species to be resolved. Third, we show how an increase in resolution improves sensitivity. Finally, we demonstrate that these methods are capable of identifying species with long genomes such as bacteria with high sensitivity.
A Comparison of Ventriculoperitoneal and Ventriculoatrial Shunts in a Population of 544 Consecutive Pediatric Patients
Authors: Rymarczuk George N , Keating Robert F , Coughlin Daniel J , Felbaum Daniel , Myseros John S , Oluigbo Chima , Yadav Bhupender , Sharma Karun , Magge Suresh N 
Published: October 2019

Abstract

BACKGROUND
Although ventriculoperitoneal shunts (VPS) remain the first-line option in most instances of pediatric hydrocephalus, the long-term efficacy of ventriculoatrial shunts (VAS) remains unknown.

OBJECTIVE
To characterize the long-term outcomes and adverse occurrences associated with both VPS and VAS at our institution.

METHODS
The authors retrospectively analyzed all cerebrospinal fluid (CSF) shunting procedures performed over a 13-yr period at a single institution. A total of 544 pediatric shunt patients were followed for at least 90 d (VPS: 5.9 yr; VAS: 5.3 yr).

RESULTS
A total of 54% of VPS and 60% of VAS required at least 1 revision. VPS demonstrated superior survival overall; however, if electively scheduled VAS lengthening procedures are not considered true “failures,” no statistical difference is noted in overall survival (P = .08). VPS demonstrated significantly greater survival in patients less than 7 yr of age (P = .001), but showed no difference in older children (P = .4). VAS had a significantly lower rate of infection (P < .05) and proximal failure (P < .001).

CONCLUSION
VAS can be a useful alternative to VPS when the abdomen is unsuitable, particularly in older children. Although VPS demonstrates superior overall survival, it should be understood that elective VAS lengthening procedures are often necessary, especially in younger patients. If elective lengthening procedures are not considered true failures, then the devices show similar survival.
Comparison of Diagnosis and Prescribing Practices Between Virtual Visits and Office Visits for Adults Diagnosed With Sinusitis Within a Primary Care Network
Authors: Johnson Kristen M , Dumkow Lisa E , Burns Kayla W , Yee Megan A , Egwuatu Nnaemeka E 
Published: October 2019

Abstract

Background
Many antibiotics prescribed in the outpatient setting result from upper respiratory tract infections (URTIs); however, these infections are often viral. Virtual visits have emerged as a popular alternative to office visits for URTIs and may be an important target for antimicrobial stewardship programs.

Methods
This retrospective cohort study evaluated adult patients diagnosed with sinusitis treated within a single primary care network. The primary objective was to compare guideline-concordant diagnosis between patients treated via virtual visits vs in-office visits. Guideline-concordant bacterial sinusitis diagnosis was based on national guideline recommendations. Secondary objectives included comparing guideline-concordant antibiotic prescribing between groups and 24-hour, 7-day, and 30-day revisits.

Results
A total of 350 patients were included in the study, with 175 in each group. Patients treated for sinusitis were more likely to receive a guideline-concordant diagnosis in the virtual visit group (69.1% vs 45.7%; P &lt; .001). Additionally, patients who completed virtual visits were less likely to receive antibiotics (68.6% vs 94.3%; P &lt; .001). Guideline-concordant antibiotic selection was similar between groups (67.5% vs 64.8%; P = .641). The median duration of therapy in both groups was 10 days (P = .88). Patients completing virtual visits were more likely to revisit for sinusitis within 24 hours (8% vs 1.7%; P = .006) and within 30 days (14.9% vs 7.4%; P = .027).

Conclusions
In adult patients presenting with sinusitis, care at a virtual visit was associated with an increase in guideline-concordant diagnosis and a decrease in antibiotic prescribing compared with in-office primary care visits. Virtual visit platforms may be a valuable tool for antimicrobial stewardship programs in the outpatient setting.
Comparison of rates of hospitalization between single and dual virus detection in a Mexican cohort of children and adults with influenza-like illness
Authors: Noyola Daniel E , Hunsberger Sally , Valdés Salgado Raydel , Powers John H , Galindo-Fraga Arturo , Ortiz-Hernández Ana A , Ramirez-Venegas Alejandra , Moreno-Espinosa Sarbelio , Llamosas-Gallardo Beatriz , Guerrero M Lourdes , Beigel John H , Ruiz-Palacios Guillermo , Perez-Patrigeon Santiago ,   Mexico Emerging Infectious Diseases Clinical Research Network ILI-002 study group
Published: October 2019

Abstract

Background
Molecular detection methods allow for the simultaneous detection of several infectious agents. This study assesses whether co-infection with two viruses as compared to one is associated with increased hospitalization in those with acute respiratory infections.

Methods
We prospectively enrolled a cohort of pediatric and adult participants with influenza-like illness during 2010-2014 in Mexico. Clinical information and respiratory samples were collected at enrollment. Respiratory viruses were detected with multiplex PCR and influenza specific RT-PCR assays. Participants were followed-up 14 and 28 days after inclusion. Severity of disease as measured by hospitalization with acute respiratory infections was compared between single and dual viral infections.

Results
Among 5,662 participants in the study, either one (n=3,285) or two (n=641) viruses were detected in 3,926 participants. Rhinovirus (n=1,433), influenza (n=888), and coronaviruses (n=703) were the most frequently detected viruses (either alone or in co-infection). Bocavirus, respiratory syncytial virus (RSV), metapneumovirus, and rhinovirus cases were hospitalized more often than other viruses. Bocavirus+rhinovirus cases were hospitalized more often than those with rhinovirus alone (but not bocavirus alone). RSV cases were more likely to be hospitalized than cases with co-infections of RSV and parainfluenza virus or coronavirus. Metapneumovirus cases were hospitalized more often than those co-infected with metapneumovirus+coronavirus.

Conclusions
In this study, detection of two viruses did not significantly increase hospitalizations compared with single virus infections. Larger studies will allow for distinguishing between sequential and simultaneous infection as well as for a better understanding of the role of each virus during the evolution of acute respiratory episodes.
A Novel and Reproducible Classification of the Vertebral Artery in the Subaxial Cervical Spine
Authors: Winter Fabian , Okano Ichiro , Salzmann Stephan N , Rentenberger Colleen , Shue Jennifer , Sama Andrew A , Girardi Federico P , Cammisa Frank P , Hughes Alexander P 
Published: October 2019

Abstract

BACKGROUND
An injury of the vertebral artery (VA) is one of the most catastrophic complications in the setting of cervical spine surgery. Anatomic variations of the VA can increase the risk of iatrogenic lacerations.

OBJECTIVE
To propose a novel and reproducible classification system that describes the position of the VA based on a 2-dimensional map on computed tomography angiographs (CTA).

METHODS
This cross-sectional retrospective study reviewed 248 consecutive CTAs of the cervical spine at a single academic institution between 2007 and 2018. The classification consists of a number that characterizes the location of the VA from the medio-lateral (ML) aspect of the vertebral body. In addition, a letter describes the VA location from the anterior-posterior (AP) aspect. The reliability and reproducibility were assessed by 2 independent raters on 200 VAs.

RESULTS
The inter- and intrarater reliability values showed the classification's reproducibility. The inter-rater reliability weighted κ-value for the ML aspect was 0.93 (95% CI: 0.93-0.93). The unweighted κ-value was 0.93 (95% CI: 0.86-1.00) for “at-risk” positions (ML grade ≥1), and 0.87 (95% CI: 0.75-1.00) for “high-risk” positions (ML grade ≥2). The weighted κ-value for the intrarater reliability was 0.94 (95% CI: 0.95-0.95). The unweighted κ-values for the intrarater reliability were 0.95 (95% CI: 0.91-0.99) for “at-risk” positions, and 0.87 (95% CI: 0.78-0.96) for “high-risk” positions.

CONCLUSION
The proposed classification is reliable, reproducible, and independent of individual anatomic size variations. The use of this novel grading system could improve the understanding and interdisciplinary communication about VA anomalies.
WHIRLY1 Regulates HSP21.5A Expression to Promote Thermotolerance in Tomato
Authors: Zhuang Kunyang , Gao Yangyang , Liu Zhuangbin , Diao Pengfei , Sui Na , Meng Qingwei , Meng Chen , Kong Fanying 
Published: October 2019

AbstractHeat stress poses a major threat to plant productivity and crop yields. The induction of heat shock proteins (HSPs) by heat shock factors is a principal defense response of plants exposed to heat stress. In this study, we identified and analyzed the heat stress-induced Whirly1 (SlWHY1) gene in tomato (Solanum lycopersicum). We generated various SlWHY1-overexpressing (OE) and SlWHY1-RNA interference (RNAi) lines to investigate the role of WHIRLY1 in thermotolerance. Compared with the wild type (WT), the OE lines showed less wilting, as reflected by their increased membrane stability and soluble sugar content and reduced reactive oxygen species (ROS) accumulation under heat stress. By contrast, RNAi lines with inhibited SlWHY1 expression showed the opposite phenotype and corresponding physiological indices under heat stress. The heat-induced gene SlHSP21.5A, encoding an endoplasmic reticulum-localized HSP, was upregulated in the OE lines and downregulated in the RNAi lines compared with the WT. RNAi-mediated inhibition of SlHSP21.5A expression also resulted in reduced membrane stability and soluble sugar content and increased ROS accumulation under heat stress compared with the WT. SlWHY1 binds to the elicitor response element-like element in the promoter of SlHSP21.5A to activate its transcription. These findings suggest that SlWHY1 promotes thermotolerance in tomato by regulating SlHSP21.5A expression.
Representation of Women in Pain Medicine Fellowships in the United States, 2017–2018
Authors: Doshi Tina L , Richter Hira C , Salisu Mariam , Samen Christelle 
Published: October 2019

AbstractObjectiveTo quantify the representation of women trainees and faculty and to explore associations between them at Pain Medicine (PM) fellowship programs in the United States.SettingPM fellowship programs accredited by the Accreditation Council for Graduate Medical Education.MethodsAll PM programs approved for at least four fellows as of December 2017 were identified. Websites of these programs were reviewed to determine the number and gender of current fellows and faculty, and programs were contacted to verify the information.ResultsA total of 56 PM programs were eligible; of these, 48 PM programs (86%) provided information about the gender distribution of fellows. Women comprised ∼25% of PM fellows. PM programs with a female rather than male fellowship program director (PD) had 2.40 times increased odds of a female trainee. Proportion of female faculty and division chief gender were not significantly associated with trainee gender composition. The adjusted odds of a faculty member being female was 1.99 times greater for PM programs with a female vs male PD and 3.13 times greater for programs with a female vs male division chief.ConclusionsWomen are underrepresented throughout all levels of academic pain medicine. The presence of women in leadership roles is associated with higher proportions of female trainees and faculty, highlighting the need for more female role models in academic pain medicine.
Near-infrared spectroscopy in evaluating psychogenic pseudosyncope—a novel diagnostic approach
Authors: Claffey P , Pérez-Denia L , Rivasi G , Finucane C , Kenny R A 
Published: October 2019

Abstract

Background
Psychogenic pseudosyncope (PPS), a conversion disorder and syncope mimic, accounts for a large proportion of ‘unexplained syncope’. PPS is diagnosed by reproduction of patients’ symptoms during head-up tilt (HUT). Electroencephalogram (EEG), a time consuming and resource intensive technology, is used during HUT to demonstrate absence of cerebral hypoperfusion during transient loss of consciousness (TLOC). Near-infrared spectroscopy (NIRS) is a simple, non-invasive technology for continuous monitoring of cerebral perfusion. We present a series of patients for whom PPS diagnosis was supported by NIRS during HUT.

Methods
Eight consecutive patients with suspected PPS referred to a syncope unit underwent evaluation. During HUT, continuous beat-to-beat blood pressure (BP), heart rate (HR) and NIRS-derived tissue saturation index (TSI) were measured. BP, HR and TSI at baseline, time of first symptom, presyncope and apparent TLOC were measured. Patients were given feedback and followed for symptom recurrence.

Results
Eight predominantly female patients (6/8, 75%) aged 31 years (16–54) were studied with (5/8, 63%) having comorbid psychiatric diagnoses, and (5/8, 63%) presenting with frequent episodes of prolonged TLOC with eyes closed (6/8, 75%). All patients experienced reproduction of typical events during HUT. Systolic BP (mmHg) increased from baseline (129.7 (interquartile range [IQR] 124.9–133.4)) at TLOC (153.0 (IQR 146.7–159.0)) (P-value = 0.012). HR (bpm) increased from baseline 78 (IQR 68.6–90.0) to 115.7 (IQR 93.5–127.9) (P-value = 0.012). TSI (%) remained stable throughout, 71.4 (IQR 67.5–72.9) at baseline vs. 71.0 (IQR 68.2–73.0) at TLOC (P-value = 0.484).

Conclusions
NIRS provides a non-invasive surrogate of cerebral perfusion during HUT. We propose HUT incorporating NIRS monitoring in the diagnostic algorithm for patients with suspected PPS.
Comparative evaluation of the physicochemical properties of nano-hydroxyapatite/collagen and natural bone ceramic/collagen scaffolds and their osteogenesis-promoting effect on MC3T3-E1 cells
Authors: Lei Xiongxin , Gao Jianping , Xing Fangyu , Zhang Yang , Ma Ye , Zhang Guifeng 
Published: October 2019

Abstract
The use of various types of calcium phosphate has been reported in the preparation of repairing materials for bone defects. However, the physicochemical and biological properties among them might be vastly different. In this study, we prepared two types of calcium phosphates, nano-hydroxyapatite (nHA) and natural bone ceramic (NBC), into 3D scaffolds by mixing with type I collagen (CoL), resulting in the nHA/CoL and NBC/CoL scaffolds. We then evaluated and compared the physicochemical and biological properties of these two calcium phosphates and their composite scaffold with CoL. Scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction spectroscopy (XRD) and compressive tests were used to, respectively, characterize the morphology, composition, distribution and the effect of nHA and NBC to collagen. Next, we examined the biological properties of the scaffolds using cytotoxicity testing, flow cytometry, immunofluorescence staining, biocompatibility testing, CCK-8 assays and RT-PCR. The results reflected that the Ca2+ released from nHA and NBC could bind chemically with collagen and affect its physicochemical properties, including the infrared absorption spectrum and compression modulus, among others. Furthermore, the two kinds of scaffolds could promote the expression of osteo-relative genes, but showed different gene induction properties. In short, NBC/CoL could promote the expression of early osteogenic genes, while nHA/CoL could upregulate late osteogenic genes. Conclusively, these two composite scaffolds could provide MC3T3-E1 cells with a biomimetic surface for adhesion, proliferation and the formation of mineralized extracellular matrices. Moreover, nHA/CoL and NBC/CoL had different effects on the period and extent of MC3T3-E1 cell mineralization.