bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolonged status epilepticus: Early recognition and prediction of full recovery in a 12‐year cohort
Authors: Sutter Raoul , Semmlack Saskia , Kaplan Peter W. , Opić Petra , Marsch Stephan , Rüegg Stephan 
Published: December 2018

SummaryObjectivesEarly identification of patients who are at risk of prolonged status epilepticus (SE) and patients with high chances of full recovery despite prolonged SE may urge clinicians to intensify treatment rather than to withdraw care. We aimed to develop prediction models based on readily available clinical parameters to predict prolonged SE at seizure onset and to identify patients with high chances for full recovery.MethodsFrom 2005 to 2016, all adult SE patients treated at the University Hospital Basel, a Swiss medical care center, were included. Multivariable Poisson regression was performed to identify predictors of prolonged SE (defined as SE for >12, >24, and >48 hours) and return to baseline from prolonged SE. The area under the receiver‐operating characteristic curves (AUROC) for prediction models was calculated.ResultsOf 467 patients, the median age was 66.7 years and mortality was 12%. Relative risk (RR) for death was 1.06 (P < 0.0001) with every SE day. In multivariable analysis, nonconvulsive SE with coma, SE severity score ≥3, and acute brain lesions at SE onset independently predicted prolonged SE with an AUROC of 0.68 for >12, 0.67 for >24, and 0.72 for >48 hours of SE. Absence of nonconvulsive SE with coma and a decreasing Charlson comorbidity index were independent predictors for return to baseline in prolonged SE with an AUROC of 0.82 and 0.76 following cross‐validation. Both associations remained significant despite adjustments for determinants of adverse outcome, such as anesthetics and vasopressors (nonconvulsive SE with coma RR = 0.24, 95% confidence interval [CI] 0.07‐0.86; comorbidity index RR = 0.87, 95% CI 0.76‐0.99).SignificanceAlthough our data indicate that identification of prolonged SE at seizure onset is unreliable, timely recognition of patients with high chances of good outcome despite prolonged SE is promising on the basis of comorbidities, type of SE, and level of consciousness. Further external validation of this prediction model is needed.
Neurocognition in childhood epilepsy: Impact on mortality and complete seizure remission 50 years later
Authors: Sillanpää Matti , Saarinen Maiju M. , Karrasch Mira , Schmidt Dieter , Hermann Bruce P. 
Published: December 2018

SummaryObjectiveTo study associations of the severity of impairment in childhood neurocognition (NC) with long‐term mortality and complete seizure remission.MethodsA population‐based cohort of 245 subjects with childhood onset epilepsy was followed up for 50 years (median = 45, range = 2‐50). Childhood NC before age 18 years was assessed as a combination of formal intelligence quotient scores and functional criteria (school achievement, working history, and psychoneurological development). Impaired NC was categorized with respect to definitions of intellectual functioning in International Classification of Diseases, 10th revision (R41.83, F70‐F73). The outcome variables, defined as all‐cause mortality and 10‐year terminal remission with the 5 past years off medication (10YTR), were analyzed with Cox regression models.ResultsOf the 245 subjects, 119 (49%) had normal childhood NC, whereas 126 (51%) had various degrees of neurocognitive impairment. During the 50‐year observation period, 71 (29%) of the subjects died, 13% of those with normal and 44% of those with impaired NC. The hazard of death increased gradually in line with more impaired cognition, reaching significance in moderate, severe, and profound impairment versus normal NC (hazard ratio [Bonferroni corrected 95% confidence interval] = 3.3 [1.2‐9.2], 4.2 [1.2‐14.2], and 5.5 [2.4‐12.3], respectively). The chance for 10YTR was highest among subjects with normal NC (61%), whereas none of those with profound impairment reached 10YTR. In the intermediate categories, the chance was, however, not directly related to the increasing severity of impairment.SignificanceThe severity of neurocognitive impairment during childhood shows a parallel increase in the risk of death. In comparison with normal NC, subjects with lower childhood NC are less likely to enter seizure remission. However, normal NC does not guarantee complete remission or prevent premature death in some individuals with childhood onset epilepsy.
Two main focal seizure patterns revealed by intracerebral electroencephalographic biomarker analysis
Authors: Gnatkovsky Vadym , Pelliccia Veronica , de Curtis Marco , Tassi Laura 
Published: December 2018

SummaryObjectiveLong‐term recording with intracerebral electrodes is commonly utilized to identify brain areas responsible for seizure generation (epileptogenic zone) and to tailor therapeutic surgical resections in patients with focal drug‐resistant epilepsy. This invasive diagnostic procedure generates a wealth of data that contribute to understanding human epilepsy. We analyze intracerebral signals to identify and classify focal ictal patterns.MethodsWe retrospectively analyzed stereo‐electroencephalographic (EEG) data in a cohort of patients either cryptogenic (magnetic resonance imaging negative) or presenting with noncongruent anatomoelectroclinical data. A computer‐assisted method based on EEG signal analysis in frequency and space domains was applied to 467 seizures recorded in 105 patients submitted to stereo‐EEG presurgical monitoring.ResultsTwo main focal seizure patterns were identified. P‐type seizures, typical of neocortex, were observed in 73 patients (69.5%), lasted 22 ± 13 seconds (mean +SD), and were characterized by a sharp‐onset/sharp‐offset transient superimposed on low‐voltage fast activity (126 ± 19 Hz). L‐type seizures were observed in 43 patients (40.9%) and consistently involved mesial temporal structures; they lasted longer (93 ± 48 second), started with 116 ± 21 Hz low‐voltage fast activity superimposed on a slow potential shift, and terminated with large‐amplitude, periodic bursting activity. In 23 patients (21.9%), the L‐type seizure was preceded by a P seizure. Spasmlike and unclassifiable EEG seizures were observed in 11.4% of cases.SignificanceThe proposed computer‐assisted approach revealed signal information concealed to visual inspection that contributes to identifying two principal seizure patterns typical of the neocortex and of mesial temporal networks.
Serum amyloid A in equine health and disease
Authors: Witkowska‐Piłaszewicz O. D. , Żmigrodzka M. , Winnicka A. , Miśkiewicz A. , Strzelec K. , Cywińska A. 
Published: December 2018

SummarySerum amyloid A (SAA) is the major acute phase protein in horses. It is produced during the acute phase response (APR), a nonspecific systemic reaction to any type of tissue injury. In the blood of healthy horses, SAA concentration is very low, but it increases dramatically with inflammation. Due to the short half‐life of SAA, changes in its concentration in blood closely reflect the onset of inflammation and, therefore, measurement of SAA useful in the diagnosis and monitoring of disease and response to treatment. Increases in SAA concentration have been described in equine digestive, reproductive and respiratory diseases and following surgical procedures. Moreover, SAA has proven useful for detection of some subclinical pathologies that can disturb training and competing in equine athletes. Increasing availability of diagnostic tests for both laboratory and field use adds to SAA's applicability as a reliable indicator of horses’ health status. This review article presents the current information on changes in SAA concentrations in the blood of healthy and diseased horses, focussing on clinical application of this biomarker.
Anchovy distribution off Peru in relation to abiotic parameters: A 32‐year time series from 1985 to 2017
Authors: Castillo Ramiro , Dalla Rosa Luciano , García Diaz Walter , Madureira Lauro , Gutierrez Mariano , Vásquez Luís , Koppelmann Rolf 
Published: December 2018

AbstractOceanographic and hydroacoustic data were obtained by theInstituto del Mar del Peru(IMARPE) during 72 cruises off the Peruvian coast between 1985 and 2017 to determine the ranges of the abiotic parameters influencing the anchovy (anchoveta) distribution and to observe the effect of the 1997–1998 El Niño event. The hydroacoustic data show a high seasonal variability in anchoveta distribution related to differences of environmental parameters as well as changes in distribution after the very strong El Niño event in 1997–1998. Geostatistic variograms were used to describe the seasonal variability and generalized additive models (GAMs) with a Tweedie distribution were applied to study the relationships between anchoveta and oceanographic parameters. The dependent variable was the value for anchoveta obtained from echosounder (nautical area scattering coefficient [NASC] of anchoveta) and the tested covariates were temperature, salinity, and dissolved oxygen at the sea surface; distance to the coast; year, latitude–longitude; and Oceanic Niño Index 1 + 2. The results show a high variability of anchoveta with seasonal differences in its distribution. Preferred abiotic conditions (temperature, salinity, oxygen) of anchoveta were 17.6–23.7°C, 32.30–35.14, and 5.9–8.7 ml/L in summer and 14.5–18.8°C, 34.81–35.12, and 5.2–6.3 ml/L in winter. The values in autumn and spring were intermediate and are considered as in transition. The anchoveta were detected at higher values after the 1997–1998 El Niño event, probably influenced by reduced standing stocks of congener fish species and by the Pacific decadal oscillation (PDO) or by a changes in climate.
Trade‐offs between carbon stocks and biodiversity in European temperate forests
Authors: Sabatini Francesco Maria , de Andrade Rafael Barreto , Paillet Yoan , Ódor Péter , Bouget Christophe , Campagnaro Thomas , Gosselin Frédéric , Janssen Philippe , Mattioli Walter , Nascimbene Juri , Sitzia Tommaso , Kuemmerle Tobias , Burrascano Sabina 
Published: December 2018

AbstractPolicies to mitigate climate change and biodiversity loss often assume that protecting carbon‐rich forests provides co‐benefits in terms of biodiversity, due to the spatial congruence of carbon stocks and biodiversity at biogeographic scales. However, it remains unclear whether this holds at the scales relevant for management, and particularly large knowledge gaps exist for temperate forests and for taxa other than trees. We built a comprehensive dataset of Central European temperate forest structure and multi‐taxonomic diversity (beetles, birds, bryophytes, fungi, lichens, and plants) across 352 plots. We used Boosted Regression Trees (BRTs) to assess the relationship between above‐ground live carbon stocks and (a) taxon‐specific richness, (b) a unified multidiversity index. We used Threshold Indicator Taxa ANalysis to explore individual species’ responses to changing above‐ground carbon stocks and to detect change‐points in species composition along the carbon‐stock gradient. Our results reveal an overall weak and highly variable relationship between richness and carbon stock at the stand scale, both for individual taxonomic groups and for multidiversity. Similarly, the proportion of win‐win and trade‐off species (i.e., species favored or disadvantaged by increasing carbon stock, respectively) varied substantially across taxa. Win‐win species gradually replaced trade‐off species with increasing carbon, without clear thresholds along the above‐ground carbon gradient, suggesting that community‐level surrogates (e.g., richness) might fail to detect critical changes in biodiversity. Collectively, our analyses highlight that leveraging co‐benefits between carbon and biodiversity in temperate forest may require stand‐scale management that prioritizes either biodiversity or carbon in order to maximize co‐benefits at broader scales. Importantly, this contrasts with tropical forests, where climate and biodiversity objectives can be integrated at the stand scale, thus highlighting the need for context‐specificity when managing for multiple objectives. Accounting for critical change‐points of target taxa can help to deal with this specificity, by defining a safe operating space to manipulate carbon while avoiding biodiversity losses.
Inhibition of glycogen synthase kinase 3β protects liver against ischemia/reperfusion injury by activating 5′ adenosine monophosphate‐activated protein kinase‐mediated autophagy
Authors: Kong Defu , Hua Xiangwei , Qin Tian , Zhang Jianjun , He Kang , Xia Qiang 
Published: December 2018

AimAutophagy has been found to play an important role in hepatic ischemia/reperfusion (I/R) injury. Our previous study has also clarified that rictor deficiency aggravated hepatic I/R injury by suppressing autophagy. Here, we explore whether autophagy participates in glycogen synthase kinase 3β (GSK3β)‐mediated cytoprotection in liver I/R.MethodsMice were treated with SB216763 to inhibit GSK3β before being subjected to hepatic I/R. Liver injury was evaluated by liver and blood samples. Autophagy was measured by detecting expression of microtubule‐associated protein 1 light chain‐3B (LC3B) II and autophagy protein 5 (ATG‐5), as well as the number of autophagosomes by transmission electron microscope. Primary hepatocytes pretreated with SB216763 for 2 h were subjected to hypoxia/reoxygenation to induce autophagy. The lactate dehydrogenase level was used to evaluate cell death and survival. Autophagy inhibitors and 5′ adenosine monophosphate‐activated protein kinase (AMPK) inhibitor were given in vivo or in vitro.ResultsSB216763 significantly increased the number of autophagosomes and the protein levels of LC3B II and ATG‐5 in liver I/R models, which was accompanied by a decline of hepatic necrosis and apoptosis. Consistent with the in vivo study, autophagy and cytoprotection were induced by the inhibition of GSK3β in the in vitro study. Moreover, pretreatment with autophagy inhibitors attenuated the cytoprotective role of autophagy in the GSK3β‐treated liver I/R models. Further analysis showed that pretreatment with an AMPK inhibitor increased mammalian target of rapamycin (mTOR) activity, decreased autophagy, and abrogated GSK3β‐ mediated liver protection.ConclusionAutophagy was induced by GSK3β inhibition through the AMPK/mTOR pathway and could substantially ameliorate liver I/R injury. Therefore, our findings strongly renew the therapeutic value of the GSK3β/autophagy axis in hepatic I/R injury.
Grading of renal cell carcinoma
Authors: Delahunt Brett , Eble John N , Egevad Lars , Samaratunga Hemamali 
Published: December 2018

Grading of renal cell carcinoma (RCC) has been recognised as a prognostic factor for almost 100 years. Numerous grading systems have been proposed, initially focusing upon a constellation of cytological features and more recently on nuclear morphology. It has been recommended that grading of RCC should be based upon nucleolar prominence/eosinophilia for grades 1–3, while grade 4 requires nuclear anaplasia (including tumour giant cells, sarcomatoid differentiation and/or rhabdoid morphology). The grading system was adopted formally by the International Society of Urological Pathology (ISUP) and subsequently by the World Health Organisation (WHO), being designated the WHO/ISUP grading classification in the fourth edition of the WHO classification tumours of the urinary system and male genital organs (2016). This grading system has been validated for both clear cell and papillary RCC. Validation studies for chromophobe RCC failed to demonstrate a correlation between grade and outcome for both the superseded Fuhrman grading system and the WHO/ISUP grading classification, and it has been recommended that these tumours not be graded. The WHO/ISUP system has been incorporated into the structured reports of the International Cancer Collaboration on Cancer Reporting for both clear cell and papillary RCC. It is also noted that other types of RCC may be graded, but it must be emphasised in the report that this is for descriptive and diagnostic purposes, and not outcome prediction. More recent studies have shown the incorporation of the presence of tumour necrosis into RCC grading to improve outcome prediction, and this has been validated in several studies.
Datasets for the reporting of neoplasia of the testis: recommendations from the International Collaboration on Cancer Reporting
Authors: Berney Dan M , Comperat Eva , Feldman Darren R , Hamilton Robert J , Idrees Muhammad T , Samaratunga Hemamali , Tickoo Satish K , Yilmaz Asli , Srigley John R 
Published: December 2018

We here describe the development of an evidence‐based cancer dataset by an International Collaboration on Cancer Reporting expert panel for the reporting of primary testicular neoplasia, and present the ‘required’ and ‘recommended’ elements to be included in the pathology report, as well as a commentary. This dataset encompasses the updated 2016 World Health Organisation classification of urological tumours, the results of an International Society of Urological Pathology consultation, and also staging with our preferred method: the American Joint Committee on Cancer version 8. Implementation of this dataset will facilitate consistent and accurate data collection between different cohorts, facilitate research, and hopefully result in improved patient management.
Renal cell carcinoma staging: pitfalls, challenges, and updates
Authors: Williamson Sean R , Taneja Kanika , Cheng Liang 
Published: December 2018

Renal cell carcinoma (RCC) is unusual among cancers in that it often grows as a spherical, well‐circumscribed mass. Increasing tumour size influences the pathological pT stage category within pT1 and pT2, with cutoffs of 40, 70 and 100 mm; however, with increasing size also comes a sharp increase in the likelihood of renal sinus or renal vein tributary invasion, such that clear cell RCC rarely reaches 70 mm without invading one of these. To clarify some previous challenges in assigning tumour stage, the American Joint Committee on Cancer 2016 tumor–node–metastasis classification has removed the requirements than vein invasion be recognised grossly and that vein walls contain muscle for the diagnosis of vein invasion. Renal pelvis invasion has also been added as an additional route to pT3a. Multinodularity or finger‐like extensions from a renal mass should be viewed with great suspicion for the possibility of vein or renal sinus invasion, and, as tumour size increases to over 40–50 mm, thorough sampling of the renal sinus interface should always be undertaken. With increasing interest in adjuvant therapy in renal cancer, the pathologist's role in RCC staging will continue to be an important prognostic parameter and a tool for selection of patients for enrolment in clinical trials.
An overview of translational prostate cancer cohorts for prognostic and predictive studies
Authors: Tolkach Yuri , Kristiansen Glen 
Published: December 2018

The aim of this review is to describe the characteristics of patient cohorts commonly used for translational biomarker research in prostate cancer and to outline the most prominent contemporary cohorts which serve as a source of prognostic and predictive biomarkers. A non‐systematic review of the literature was performed to identify and summarise well‐characterized translational prostate cancer cohorts that provide state‐of‐the‐art characterization of (i) primary and (ii) metastatic and castration‐resistant prostate cancer. The main advantages and features of these cohorts are a substantial number of patients, unique patient groups, comprehensive genetic characterisation of tumours using multi‐omics/next‐generation sequencing approaches, high‐quality control standards and fully or partially open data for the research community. This overview includes the contemporary cohorts which serve as a rich source of new targets for prognostic and predictive biomarkers as well as a reference database for validation of known biomarkers, therefore representing the cohorts whose impact extends over the current state of biomarker research into the near future (5–10 years).
Consumerism in online health information search and self‐tracking devices
Authors: Ertiö Titiana , Räsänen Pekka 
Published: December 2018

AbstractThe Internet hosts a plethora of health information and has become a popular source users turn to when looking up information. Nonetheless, the existence of this wealth of online health information generates challenges related to access and user skills. Whereas previous studies surveyed a cross‐section of users, our aim is to complement them with a population‐level study. We use nationally representative data collected by Statistics Finland between 2006 and 2016 to investigate the extent to which online health information search and use of self‐tracking devices associate with social, economic and demographic factors. We have used descriptive statistics and logistic regressions to show that, in 2016, disparities still existed in how Finns make use of the health information found online as well as appropriate new devices such as self‐tracking devices. The population level of this study aids us in understanding the degree of adoption of new technologies used by different demographics. We show that, despite having access to the Internet, certain factors influence actual usage negatively. Looking forward, a key limitation of our study is a lack of measures to determine how these demographics use health information to adjust their behaviour. In the Nordic context, important research implications relate to the persisting digital divides in health technology adoption.
“Mum, did you just leave that tap running?!” The role of positive pester power in prompting sustainable consumption
Authors: O’Neill Claire , Buckley Joan 
Published: December 2018

AbstractThis paper offers novel insights on the socio‐structural factors that sustain (or break) everyday behaviours in the home. Specifically, the adoption of sustainable consumption in the home as influenced by Green‐School children is explored. The findings presented are derived from surveys with Green‐School (Eco‐School) children and in‐depth interviews with their parents. The process of sustainable consumption adoption in the home, in the context of the Green‐Schools programme, is explored with an aim to understand if, and how, Green‐School children affect behaviours in the home. The findings enlighten our understanding of not only how environmental education programmes are reconciling the Dominant Social Paradigm with the New Environmental Paradigm, but also in terms of how sustainable consumption in the home, such as recycling and water and energy conservation, are initiated and reinforced by children through their use of positive pester power.
The importance of diagnostic imaging of mycetoma in the foot
Authors: Guerra‐Leal Jesús D. , Medrano‐Danés Luis A. , Montemayor‐Martinez Alberto , Pérez‐Rodríguez Edelmiro , Luna‐Gurrola César E. , Arenas‐Guzman Roberto , Salas‐Alanís Julio C. 
Published: December 2018

AbstractBackgroundMycetoma is a chronic, localized infection caused by fungi and bacteria. It usually affects the skin, subcutaneous tissue, and bone of exposed areas with deformity of the affected limb, ulcers, and fistula; however, pain is not severe, therefore the patient comes late to hospital for care.ObjectiveTo establish the diagnosis of mycetoma in the foot by imaging and identify the principal radiological signs.Materials and MethodsSix patients with foot mycetoma were evaluated with plain x‐ray, ultrasound, and magnetic resonance (MR) after confirming the diagnosis by histopathology and culture.ResultsAll patients presented the MR “dot‐in‐circle” sign; four presented “punched out” bone lesions on plain x‐ray. The six patients had fistulas, ulceration, a seropurulent exudate, edema, and a foot deformity. Four patients had N. brasiliensis infection with positive anti‐Nocardia IgG antibodies, and only half presented bone lesions.ConclusionCharacteristic findings were foot deformity, edema, bone lesions, ulcers, fistulas and the presence of the “dot‐in‐circle” sign. We recommend a comprehensive study of patients with plain x‐ray and MR.