bluuebunny/crossref_metadata_2025_split huggingface dataset:
First real-world evidence of sparsentan efficacy in patients with IgA nephropathy treated with SGLT2 inhibitors
Authors: Schanz Moritz , Seikrit Claudia , Hohenstein Bernd , Zimmermann Aline , Kraft Leonie , Schricker Severin , Berger Susann , Schwab Andrea , Oberacker Tina , Latus Joerg 
Published: December 2024

ABSTRACT

Background
Sparsentan, a dual-acting antagonist for both the angiotensin II receptor type 1 and the endothelin receptor type A, has emerged as a promising therapeutic agent for the treatment of IgA nephropathy (IgAN). Following the publication of the PROTECT trial, sparsentan recently received approval for the treatment of IgAN in Europe. However, it remains uncertain whether an additive effect can be observed in the context of existing treatment with sodium-glucose co-transporter 2 (SGLT2) inhibitors, given that the PROTECT study did not investigate this dual therapy approach.

Methods
A total of 23 patients with IgAN were treated with sparsentan via the Managed Access Programme between December 2023 and August 2024. The patients were stable on maximum tolerated doses of renin–angiotensin system (RAS) and SGLT2 inhibitors, with an estimated glomerular filtration rate (eGFR) &gt;30 mL/min/1.73 m² and a urine protein/creatinine ratio (UPCR) &gt;0.75 g/g.

Results
In the 23 patients, median (IQR) baseline eGFR (CKD-EPI) was 42 mL/min/1.73 m2 (32–63) and median baseline UPCR was 1.5 g/g (0.9–1.8). After initiation of sparsentan, UPCR significantly decreased (P &lt; 0.0001) to a median of 0.85 g/g (0.42–1.15) in the 2-week follow-up and further declined (P = 0.001) to a median of 0.60 g/g (0.32–0.82) after 14 weeks, equivalent to a relative reduction in proteinuria up to 62% (45–74). A similar significant reduction was observed for the urine albumin/creatinine ratio. No drug-related serious adverse events were reported.

Conclusions
In this real-world setting, sparsentan shows a significant impact on proteinuria, leading to a relative reduction of 62% in UPCR after 14 weeks and beyond, even in patients already receiving SGLT2 inhibitors.
Admission control algorithm for visible light communication random access network under delay and jitter constraints
Authors: Sun Hongliang , Liu Zhihui , Wang Chao , Li Dan 
Published: December 2024

Abstract
This paper proposes a random access network admission control algorithm under delay and jitter constraints to efficiently guarantee the quality of service of a visible light communication system. The multi-packet reception technology is considered to enhance network service, and the interrupted Bernoulli process is used to model the arrival process of packets. The queuing model of the system is constructed from the perspective of a single transmission link, and this paper derives the probability of successful transmission for the terminals. The delay and jitter performance are evaluated according to the state transition matrix and Little’s law. The article set up the optimization problem with the goal of maximizing the throughput and the constraint of transmission probability. To solve the optimization problem better, we improve the tunicate swarm algorithm. Moreover, an admission control algorithm is designed under delay and jitter constraints. Simulation results demonstrate the influence of different parameters on the algorithm.
Internet of vehicles intrusion detection method based on CFS-COA feature selection and spatio-temporal feature extraction
Authors: Yang Zhongjun , Zhang Jixue , Su Beimin 
Published: December 2024

Abstract
With the rapid spread of the Internet of Vehicles (IoV) technology, vehicle network security is facing increasingly severe challenges. Intrusion detection technology has become a crucial tool for ensuring the information security of IoV. Since the traffic data of the IoV is large and has spatio-temporal characteristics, most previous studies are based on a single deep learning method to extract temporal or spatial features, which does not fully extract features of IoV data. To address the above issues, a spatio-temporal feature extraction model with feature selection is proposed. First, to solve the problem of long detection time with huge data traffic, a new feature selection method is proposed to screen the optimal feature subset by combining the correlation-based feature selection method with the crayfish optimization algorithm (CFS-COA). Second, the selected optimal features are used in a spatio-temporal feature extraction model that combines a Temporal Convolutional Network and a Bidirectional Gated Recurrent Unit (TCN-BiGRU) for classification. Finally, the performance of the model is evaluated using two types of datasets: the NSL-KDD and UNSW-NB15 datasets for external communications, and the Car-Hacking dataset for in-vehicle networks. The experimental results indicate that the proposed model demonstrates high classification performance and lightweight characteristics, achieving 100% accuracy on the Car-Hacking dataset.
The meaning of Mr. Tumnus: classical epic and the making of modern fantasy
Authors: Pogorzelski Randall 
Published: December 2024

Abstract
The faun Mr. Tumnus in C. S. Lewis’s The Lion, the Witch and the Wardrobe evokes a layering of pasts that both Lewis and J. R. R. Tolkien identify in their scholarly work as a key characteristic of Virgil’s Aeneid and of classical epic more generally. Tolkien discusses the epic layering of pasts as a shared feature of both Beowulf and the Aeneid, and he describes in letters his adoption of the literary technique of those poems in his fiction. Lewis treats the temporality of the Aeneid as a revolution in epic poetry in his Preface to Paradise Lost, and he less explicitly uses it in his Chronicles of Narnia. Fauns in Latin poetry are not simply Roman versions of Greek satyrs, but they represent a version of the same layering of pasts in epic that Lewis and Tolkien identify. By introducing both Lucy Pevensie and readers to Narnia with a faun, Lewis characterizes Narnia not only as a magical realm but also as an epic one.
Maxillary protraction anchored on miniplates versus miniscrews: three-dimensional dentoskeletal comparison
Authors: Miranda Felicia , Garib Daniela , Silva Ivan , Bastos José Carlos da Cunha , Aliaga-Del Castillo Aron , Yatabe Marilia , de Clerck Hugo , Cevidanes Lucia H S 
Published: December 2024

Abstract

Objective
This retrospective study aimed to compare the three-dimensional (3D) outcomes of the novel miniscrew-anchored maxillary protraction (MAMP) therapy and the bone-anchored maxillary protraction (BAMP) therapy.

Methods
The sample comprised growing patients with skeletal Class III malocclusion treated with two skeletal anchored maxillary protraction protocols. The MAMP group comprised 22 patients (9 female, 13 male; 10.9 ± 0.9 years of age at baseline) treated with Class III elastics anchored on a hybrid hyrax expander in the maxilla and two mandibular miniscrews distally to the permanent canines. The BAMP group comprised 24 patients (14 female, 10 male; 11.6 ± 1.1 years of age at baseline) treated with Class III elastic anchored in two titanium miniplates in the infra-zygomatic crest and two miniplates in the mesial of the mandibular permanent canines. Three-dimensional displacements were measured in the pre- and post-treatment cone-beam computed tomography scans superimposed on the cranial base using the Slicer Automated Dental Tools module of 3D Slicer software (www.slicer.org). Mean differences (MD) between groups and 95% confidence interval (CI) were obtained for all variables. Intergroup comparison was performed using the Analysis of Covariance (P &lt; .05).

Results
Both groups showed improvements after treatment. The MAMP group showed a smaller anterior (MD: −1.09 mm; 95% CI, −2.07 to −0.56) and 3D (MD: −1.27 mm; 95% CI, −2.16 to −0.74) displacements of the maxilla after treatment when compared with BAMP. Both groups showed negligible and similar anteroposterior changes in the mandible (MD: 0.33 mm; 95% CI, −2.15 to 1.34). A greater increase in the nasal cavity width (MD of 2.36; 95% CI, 1.97–3.05) was observed in the MAMP group when compared with BAMP.

Limitations
The absence of an untreated control group to assess the possible growth impact in these findings is a limitation of this study.

Conclusion
Both BAMP and MAMP therapies showed adequate 3D outcomes after treatment. However, BAMP therapy produced a greater maxillary advancement with treatment, while MAMP therapy showed greater transversal increases in the nasal cavity.
How to prevent 3 million deaths worldwide: a systematic review of occupational accident research—a factor- and cost-based approach
Authors: Cañaveras Perea Rosa María , Tejada Ponce Ángel , Sánchez González María Pilar 
Published: December 2024

Abstract
Occupational accidents have emerged as a global concern, necessitating a comprehensive examination of their determinants and associated costs. This review aims to summarize, synthesize, and organize the factors and cost drivers of occupational accidents, exploring whether there is a gender perspective. Adhering to PRISMA guidelines, we performed a narrative synthesis to systematically review relevant literature. A systematic search was conducted in the electronic databases PubMed, Web of Science, and Scopus. Two researchers screened all records to eliminate any duplicates, and they selected the articles for full review. A third researcher was consulted to resolve discrepancies and reach a consensus. The analysis of 15 studies revealed diverse perspectives; in terms of determinants, studies on organizational aspects and the theory of human error were grouped together, while in cost drivers, the human capital model and willingness to pay were the most frequently used. Gender, meanwhile, is identified as a determinant variable for accident rate. Additionally, limitations such as data underestimation were noted in the existing literature. The review highlights the need for empirical studies capable of addressing both determinants and cost drivers. It also provides guidelines for researchers to design studies that are more comparable across different contexts, including the gender debate.
Metataxonomic analysis of halophilic archaea community in two geothermal oases in the southern Tunisian Sahara
Authors: Najjari Afef , Elmnasri Khaled , Cherif Hanene , Burleigh Stephen , Guesmi Amel , Mahjoubi Mouna , Linares-Pastén Javier A , Cherif Ameur , Ouzari Hadda-Imene 
Published: December 2024

Abstract
This study assesses halophilic archaea’s phylogenetic diversity in southern Tunisia’s geothermal water. In the arid southern regions, limited surface freshwater resources make geothermal waters a vital source for oases and greenhouse irrigation. Three samples, including water, sediment, and halite soil crust, were collected downstream of two geothermal springs of the Ksar Ghilane (KGH) and Zaouet Al Aness (ZAN) oases, Tunisia. The samples were subjected to 16S rRNA gene sequencing using the Illumina Miseq sequencing approach. Several haloarchaea were identified in the geothermal springs. The average taxonomic composition revealed that 20 out of 33 genera were shared between the two geothermal sources, with uneven distribution, where the Halogranum genus was the most represented genus with an abundance of 18.9% and 11.58% for ZAW and KGH, respectively. Several unique site-specific genera were observed: Halonotius, Halopelagius, Natronorubrum, and Haloarcula in ZAN, and Haloprofundus, Halomarina, Halovivax, Haloplanus, Natrinema, Halobium, Natronoarchaeum, and Haloterrigena in the KGH pool. Most genus members are typically found in low-salinity ecosystems. These findings suggest that haloarchaea can disperse downstream from geothermal sources and may survive temperature and chemical fluctuations in the runoff.
Intrafamilial relations between clergy and laity: the case of the Nemours family at the turn of the twelfth and thirteenth centuries
Authors: Casano-Skaghammar Sarah 
Published: December 2024

Abstract
Medieval theorists spilt much ink identifying the divisions within society, pitting the powers of the Church against those of the laity. However, by turning to documentary sources, historians have revealed a much more complex reality. This article contributes to this wider picture by bringing to light the intrafamilial relations between the clergy and laity of the house of Nemours around the turn of the twelfth and thirteenth centuries. This family provided numerous servants both to the Capetians and to the Church. These individuals managed to maintain harmonious relations with their relatives, notwithstanding the challenges and constraints of their respective roles.
A chromosome-level genome assembly of the Peruvian Algarrobo (Neltuma pallida) provides insights on its adaptation to its unique ecological niche
Authors: La Torre Renato , Hamilton John P , Saucedo-Bazalar Manuel , Caycho Esteban , Vaillancourt Brieanne , Wood Joshua C , Ramírez Manuel , Buell C Robin , Orjeda Gisella 
Published: December 2024

Abstract
The dry forests of northern Peru are dominated by the legumous tree Neltuma pallida which is adapted to hot arid and semiarid conditions in the tropics. Despite having been successfully introduced in multiple other areas around the world, N. pallida is currently threatened in its native area, where it is invaluable for the dry forest ecosystem and human subsistence. A major tool for enhancing ecosystem conservation and understanding the adaptive properties of N. pallida to dry forest ecosystems is the construction of a reference genome sequence. Here, we report on a high-quality reference genome for N. pallida. The final genome assembly size is 403.7 Mb, consisting of 14 pseudochromosomes and 63 scaffolds with an N50 size of 26.2 Mb and a 34.3% GC content. Use of Benchmarking Universal Single Copy Orthologs revealed 99.2% complete orthologs. Long terminal repeat elements dominated the repetitive sequence content which was 51.2%. Genes were annotated using N. pallida transcripts, plant protein sequences, and ab initio predictions resulting in 22,409 protein-coding genes encoding 24,607 gene models. Comparative genomic analysis showed evidence of rapidly evolving gene families related to disease resistance, transcription factors, and signaling pathways. The chromosome-scale N. pallida reference genome will be a useful resource for understanding plant evolution in extreme and highly variable environments.
GOplan: an R package for animal breeding program design via integrating Gene Flow and Bayesian optimization methods
Authors: Huang Qianqian , Zhou Lei , Xue Yahui , Du Heng , Zhuo Yue , Mao Ruihan , Liu Yaoxin , Yan Tiantian , Li Wanying , Wang Xiaofeng , Liu Jianfeng 
Published: December 2024

Abstract
The design of breeding programs is crucial for maximizing economic gains. Simulation provides the most efficient measures to test these programs, as real-world trials are often costly and time-consuming. We developed GOplan, a comprehensive and user-friendly R package designed to develop animal breeding programs considering pure-bred populations and crossbreeding systems. Compared with other traditional simulators, it has mainstream crossbreeding frameworks that streamline modeling and use Gene Flow and Bayesian optimization methods to enhance breeding program efficiency. GOplan includes 3 key functions: runCore() to evaluate the effects of nucleus breeding programs, runWhole() to predict economic outcomes and the production performance of crossbreeding systems, and runOpt() to optimize crossbreeding structures for greater profitability. These functions support breeders in better planning and accelerating breeding goals. Additionally, the application of Bayesian optimization algorithms in this study provides valuable insights for developing new optimization algorithms in the future. The software is available at https://github.com/CAU-TeamLiuJF/GOplan.
Selfing Shapes Fixation of a Mutant Allele Under Flux Equilibrium
Authors: Xiao Yu , Lv Yan-Wen , Wang Zi-Yun , Wu Chao , He Zi-Han , Hu Xin-Sheng 
Published: December 2024

Abstract
Sexual reproduction with alternative generations in a life cycle is an important feature in eukaryotic evolution. Partial selfing can regulate the efficacy of purging deleterious alleles in the gametophyte phase and the masking effect in heterozygotes in the sporophyte phase. Here, we develop a new theory to analyze how selfing shapes fixation of a mutant allele that is expressed in the gametophyte or the sporophyte phase only or in two phases. In an infinitely large population, we analyze a critical selfing rate beyond which the mutant allele tends to be fixed under equilibrium between irreversible mutation and selection effects. The critical selfing rate varies with genes expressed in alternative phases. In a finite population with partial self-fertilization, we apply Wright's method to calculate the fixation probability of the mutant allele under flux equilibrium among irreversible mutation, selection, and drift effects and compare it with the fixation probability derived from diffusion model under equilibrium between selection and drift effects. Selfing facilitates fixation of the deleterious allele expressed in the gametophyte phase only but impedes fixation of the deleterious allele expressed in the sporophyte phase only. Selfing facilitates or impedes fixation of the deleterious allele expressed in two phases, depending upon how phase variation in selection occurs in a life cycle. The overall results help to understand the adaptive strategy that sexual reproductive plant species evolve through the joint effects of partial selfing and alternative generations in a life cycle.
Home Ambient Temperature and Self-reported Attention in Community-Dwelling Older Adults
Authors: Baniassadi Amir , Yu Wanting , Travison Thomas , Day Ryan , Lipsitz Lewis , Manor Brad 
Published: December 2024

Abstract

Background
Climate change is expected to disrupt weather patterns across the world, exposing older adults to more intense and frequent periods of hot weather. Meanwhile, lab-based studies have established a causal relationship between ambient temperature and cognitive abilities, suggesting the expected rise in temperature may influence older adults’ cognitive functioning. Nevertheless, it is not clear whether, and to what extent, the temperature variations in older adults’ own homes - which unlike lab settings is under their control - influence their cognitive functioning. Our objective was to provide proof-of-concept that home ambient temperature influences self-reported ability to maintain attention in older adults.

Methods
We conducted a longitudinal observational study; continuously monitoring the home ambient temperature and self-reported difficulty keeping attention for 12 months in a cohort of community-dwelling older adults living in Boston, MA.

Participants
47 adults aged 65 and older.

Results
We observed a U-shaped relationship between home ambient temperature at the time of assessment and the odds ratio (OR) of reporting difficulty keeping attention such that the OR was lowest between 20 – 24 ˚C and doubled when moving away from this range by 4 ˚C in either direction.

Discussion
Our results suggest that even under the current climate a considerable portion of older adults encounter indoor temperatures detrimental to their cognitive abilities. Climate change may exacerbate this problem, particularly among low-income and underserved older adults. Addressing this issue in public health and housing policy is essential to building climate-resiliency in this vulnerable population.
The Relationship Between Subjective Cognitive Decline and Cognitive Leisure Activity Engagement: A Systematic Review
Authors: Akbayrak Emine , Powell Philip A , Tunc Neslihan , Barnes Sarah 
Published: December 2024

Abstract

Background and Objectives
Subjective cognitive decline (SCD) is a common experience of self-perceived decline without objective cognitive impairment. It has been theorized that SCD is associated with participation in cognitive leisure activities (CLAs), but the evidence base is multifarious and unclear. The purpose of this systematic review was to synthesize current evidence to determine the association between SCD and CLA engagement.

Research Design and Methods
Systematic searches were conducted in EMBASE, MEDLINE, PsycINFO, and Web of Science (last searched April 2023). Data were extracted against a priori inclusion criteria and synthesized narratively using Synthesis without Meta-Analysis guidelines. Risk of bias was assessed using the Newcastle–Ottawa Scale (NOS) and Mixed Methods Appraisal Tool (MMAT). Reporting follows PRISMA guidelines.

Results
From 4,447 records, 11 articles were included. Due to study heterogeneity, evidence on SCD and CLA association is inconclusive. Although a modest correlation was found between greater engagement in CLA and fewer reports of SCD, the heterogeneity in study designs and outcomes, particularly in those addressing only perceived memory decline and CLA engagement, challenges definitive conclusions on this relationship. Evidence from mixed-method and qualitative studies indicated that perceived memory decline may cause negative feelings, such as shame and frustration, which may influence participating in CLA.

Discussion and Implications
These findings suggest that participation in CLA is moderately associated with, and may act protectively against, SCD. However, establishing a directional or causal relationship between CLA participation and SCD outcomes requires further investigation through longitudinal and/or interventional studies.
Advances in the Study of Senescence Mechanisms in the Genus Paeonia
Authors: Wang Yuxuan , Sun Miao , Zhu Wei , Chen Le , Zhu Shaocai , Zhao Jiageng , Teixeira da Silva Jaime A , Yu Xiaonan 
Published: December 2024

Abstract
Tree and herbaceous peony are considerably important ornamental plants within the genus Paeonia, and hold substantial horticultural value. This review summarizes the progress in research on the senescence mechanisms of tree and herbaceous peony flowers, focusing on the regulation of gene expression, hormonal interactions, and the influence of environmental factors on senescence. Using high-throughput sequencing technologies, key genes displaying differential expression during senescence have been identified, and these play central roles in hormone signaling and cellular senescence. The interactions among plant hormones, including ethylene, abscisic acid, gibberellins, cytokinins, and auxins, also play key roles in the regulation of senescence. Adjustments in antioxidant levels, as well as water and energy metabolism, are critical factors in the delay of senescence. Environmental factors, including light, temperature, drought, and salt stress, also significantly affect senescence. Additionally, this review proposes future research directions, including the expansion of the molecular regulatory network of senescence in Paeonia, the use of gene editing technologies like CRISPR/Cas9, multi-omics studies, and exploratory comparative research on spatial biology senescence mechanisms. These studies aim to deepen our understanding of the molecular mechanisms that underlie senescence in Paeonia, and provide a scientific basis for cultivar improvement and postharvest management of these ornamental commodities in the horticultural industry.