bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative Opioid Prescribing and Consumption Patterns after Tonsillectomy
Authors: Choo Stephanie , Nogan Stephen , Matrka Laura 
Published: July 2019

ObjectivesDespite increased concern with the opioid epidemic, literature remains scant regarding narcotic prescription and use following tonsillectomy.Study DesignRetrospective cohort study with telephone interview.Subject and MethodsA chart review from January to August 2018 evaluated the difference between prescribed amounts of narcotic and patient‐reported usage following tonsillectomy (Current Procedural Terminology codes 42821 and 42826). Patients were excluded if they used opioids for chronic pain, had a history of chronic opioid use or substance abuse, or underwent tonsillectomy to exclude malignancy. A telephone interview assessed opioid and nonopioid usage and pain control postoperatively, including amount and form of narcotics remaining.ResultsSixty‐four patients were enrolled at a mean 4.47 months after tonsillectomy. The mean ± SD prescribed morphine milligram equivalent (MME) was 456.1 ± 281.7, with only 302.8 ± 206.2 consumed. The mean MME prescribed per day was 74.1 ± 44.8, and average days of narcotic usage postoperatively was 9.6 ± 4.6, correlating with a mean MME per day of 49.2 ± 34.3 if the maximum prescribed dose per day was consumed. Fifty‐four (84.4%) patients reported pain as well controlled. Forty‐three (67.2%) patients reported residual narcotic medication, with 228.1 ± 208.5 MMEs remaining per patient. Narcotic solutions were more completely consumed than tablet forms, with 23.1% and 44.0% remaining, respectively. Patients cited uncertainty about safe disposal and safeguarding for future use as reasons for keeping residual narcotic.ConclusionsPatient‐reported narcotic use is significantly lower than the amount prescribed after tonsillectomy for benign disease. Providers can use these data to adjust narcotic‐prescribing patterns while maintaining appropriate pain management for patients undergoing tonsillectomy.
ADC quantification to classify patients candidate to receive bevacizumab treatment for recurrent glioblastoma
Authors: Asenjo García Beatriz , Navarro Guirado Félix , Nagib Raya Fátima , Vidal Denis María , Bravo Rodríguez Francisco , Galán Montenegro Pedro 
Published: July 2019

Background Recurrent high-grade gliomas progressing after surgery and temozolomide plus radiation therapy have traditionally been treated using antiangiogenic drugs as the first-line therapy. Since the phase 3 EORTC 26101 trial showed no significant benefit of administering antiangiogenic drugs, the need to identify a biomarker to classify subgroups of potential responders has increased. Purpose To investigate the feasibility of using apparent diffusion coefficient as a predictor of the response of recurrent high-grade gliomas to bevacizumab or classifier for patients showing better response. Material and Methods This retrospective study analyzed magnetic resonance images obtained from 39 patients at the time of high-grade glioma progression who were treated using bevacizumab. The apparent diffusion coefficient maps were quantified and modelled as a mixture of Gaussian functions. The correlation of their descriptors and the time to second progression was studied. Log-rank tests were performed to determine the power of these descriptors as the classifiers for patients exhibiting better survival. Results None of the descriptors showed correlation with time to second progression (r < 0.35) but several of them stratified subgroups showing a better time to second progression passing log-rank tests ( P <  0.02). Conclusion Apparent diffusion coefficient cannot be used to predict the time to second progression of recurrent high-grade gliomas treated with bevacizumab, but it can stratify groups with better time to second progression distributions.
Sudden Sensorineural Hearing Loss Following Wasp Sting and Successful Treatment With Intratympanic Steroids
Authors: Anyah Anwuli , Visconti Michael , Spoto James 
Published: July 2019

Objective: A sting by a Vespula vulgaris (wasp) should be considered as a cause of sudden sensorineural hearing loss. Although the mechanism of this cause is not well understood, management approach is similar to idiopathic sudden sensorineural hearing loss. Methods: We describe a novel case of sudden sensorineural hearing loss encountered at a community otolaryngology clinic. It developed in a 26-year-old man after a sting to the ear canal by a V vulgaris (wasp) species. Results: The patient failed to respond to oral steroids, but had complete recovery to normal hearing levels with intratympanic steroids. Conclusions: Sudden sensorineural hearing loss can be caused by the sting of a V vulgaris species and may be resolved with the use intratympanic steroids.
Fibromyalgia in the Patients With Allergic Rhinitis: Its Prevalence and Impact on the Quality of Life
Authors: Gultuna Selcan , Tezel Nihal , Ozalp Ates Funda Seher 
Published: July 2019

Background Allergic rhinitis (AR) is a common allergic diseases which affect a patient’s quality of life. Another important disease which has a negative impact on quality of life is fibromyalgia (FM). Some studies have suggested that a probable relationship exists between atopic diseases and FM. Objectives This study was designed to determine the prevalence of FM and its impact on quality of life among AR patients. Methods One hundred five consecutive adult patients with AR who were between 18 and 57 years old were prospectively recruited in this study between April 2017 and May 2018. All patients were evaluated for the presences of FM. Patients were diagnosed with FM according to the classification criteria of the 2010 American College of Rheumatology. The patients’ quality of life was evaluated by Turkish versions of the Rhinoconjunctivitis Quality of Life Questionnaire and the Nottingham Health Profile (NHP). Results Thirty-four patients were diagnosed as having FM (32.4%). The percentage of FM was considerably higher than in the general population (2%–5%). Median individual domain scores except practical problems ( P = .108) and eyes symptoms ( P = .227) were significantly higher in AR with FM patients ( P < .001). All median levels of the NHP domains were significantly higher in AR with FM patients ( P < .001). Conclusion We would like to suggest that FM may be considered as one of the overlooked comorbid conditions in AR patients. Physicians should be aware of the occurrence of FM, especially in patients with impaired quality of life.
Pemetrexed, Bevacizumab, or the Combination As Maintenance Therapy for Advanced Nonsquamous Non–Small-Cell Lung Cancer: ECOG-ACRIN 5508
Authors: Ramalingam Suresh S. , Dahlberg Suzanne E. , Belani Chandra P. , Saltzman Joel N. , Pennell Nathan A. , Nambudiri Gopakumar S. , McCann John C. , Winegarden Jerome D. , Kassem Mohammed A. , Mohamed Mohamed K. , Rothman Jan M. , Lyss Alan P. , Horn Leora , Stinchcombe Thomas E. , Schiller Joan H. 
Published: July 2019

PURPOSE Pemetrexed or bevacizumab is used for maintenance therapy of advanced nonsquamous non–small-cell lung cancer (NSCLC). The combination of bevacizumab and pemetrexed has also demonstrated efficacy. We conducted a randomized study to determine the optimal maintenance therapy. PATIENTS AND METHODS Patients with advanced nonsquamous NSCLC and no prior systemic therapy received carboplatin (area under the curve, 6), paclitaxel (200 mg/m2), and bevacizumab (15 mg/kg) for up to four cycles. Patients without progression after four cycles were randomly assigned to maintenance therapy with bevacizumab (15 mg/kg), pemetrexed (500 mg/m2), or a combination of the two agents. The primary end point was overall survival, with bevacizumab serving as the control group. RESULTS Of the 1,516 patients enrolled, 874 (57%) were randomly assigned after induction therapy to one of the three maintenance therapy groups. With a median follow-up of 50.6 months, median survival with pemetrexed was 15.9 months, compared with 14.4 months with bevacizumab (hazard ratio [HR], 0.86; P = .12); median survival with pemetrexed and bevacizumab was 16.4 months (HR, 0.9; P = .28); median progression-free survival was 4.2, 5.1 (HR, 0.85; P = .06), and 7.5 months (HR, 0.67; P < .001) for the three groups, respectively. Incidence of worst grade 3 to 4 toxicity was 29%, 37%, and 51%, respectively, for bevacizumab, pemetrexed, and the combination regimen. CONCLUSION Single-agent bevacizumab or pemetrexed is efficacious as maintenance therapy for advanced nonsquamous NSCLC. Because of a lack of survival benefit and higher toxicity, the combination of bevacizumab and pemetrexed cannot be recommended.
Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town
Authors: Hadebe Sabelo , Chengalroyen Melissa , Guler Reto , Nakedi Kehilwe , Koch Anastasia , Makatsa Mohau , Shey Muki , Parihar Suraj P. , Bryson Bryan , Marakalala Mohlopheni J. , Ndlovu Hlumani 
Published: July 2019

Tuberculosis (TB), caused by the highly infectious Mycobacteriumtuberculosis, remains a leading cause of death worldwide, with an estimated 1.6 million associated deaths reported in 2017. In South Africa, an estimated 322,000 people were infected with TB in 2017, and a quarter of them lost their lives due to the disease. Bacille Calmette-Guérin (BCG) remains the only effective vaccine against disseminated TB, but its inability to confer complete protection against pulmonary TB in adolescents and adults calls for an urgent need to develop new and better vaccines. There is also a need to identify markers of disease protection and develop novel drugs. On March 25th 2019, the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town hosted the second annual World TB Day nanosymposium. The theme of the nanosymposium was “Intervening across the spectrum of TB II” and the goal was to commemorate World TB Day by showcasing research insights shared by early-career scientists and researchers in the field. The speakers spoke on four broad topics: identification of novel drug targets, development of host-directed drug therapies, transmission of TB and immunology of TB/HIV co-infections. Assistant Professor Bryan Bryson gave a highly interesting keynote address that showcased the application of engineering tools to answer fundamental biological questions, particularly in the context of TB.
Orthodontic management of patients with autistic spectrum disorder
Authors: Ali Hesham , Mushtaq Brekhna , Malik Ovais 
Published: July 2019

Autism is a life-long developmental disability that affects how people perceive the world and interact with others. The aetiology of autism has not been clearly identified. Affected individuals experience difficulty in social interaction and changes in their environment. There appears to be a higher percentage of malocclusion within the population with special needs than the normal population, and the demand for orthodontic treatment from this group of patients is likely to increase in line with awareness of autism and access to care. The strategies available to manage patients with autism successfully are discussed here. CPD/Clinical Relevance: Understanding the difficulties faced by individuals affected by autistic spectrum disorder and anticipating the challenges in the provision of their care is of paramount importance in the context of their orthodontic management. These challenges, and the strategies available to successfully negotiate them, are concisely presented.
The multifactorial aetiology of gingival overgrowth: a case report illustrating diagnosis and management
Authors: Jablonski Rachael Y , Rushworth Bethany , Durey Kathryn A 
Published: July 2019

Gingival overgrowth is the enlargement of gingival tissues and has various underlying aetiological factors. This case report highlights the multifactorial aetiology of gingival overgrowth for a patient who was prescribed an immunosuppressive strategy following renal transplantation, had poor levels of oral hygiene and a diet deficient in fruit and vegetables. The report highlights the importance of a detailed assessment to identify all underlying factors and demonstrates how a referral to the specialist services for gingival overgrowth led to a diagnosis of vitamin C deficiency. It also illustrates how both patient engagement and a conservative cause-related therapy can achieve a satisfactory resolution without any surgical intervention. CPD/Clinical Relevance: This case report highlights the importance of a detailed assessment to diagnose all relevant underlying aetiological factors involved in the development of gingival overgrowth. It also illustrates how both patient engagement and a conservative cause-related therapy can achieve a satisfactory resolution of gingival overgrowth without any surgical intervention.
Primary B-Cell lymphoma of the mandible: a potentially difficult diagnosis
Authors: King Hudson , Rogers Simon 
Published: July 2019

There are many causes of a persistent unilateral numbness of the lower lip. A case report of a 34-year-old normally fit and well male, whose symptoms of numbness of the mandibular division of the right trigeminal nerve represented the rare diagnosis of a primary B-cell lymphoma of the mandible, is presented here. The patient's presentation and management, reasons for the difficulty in ascertaining a definitive diagnosis, as well as invaluable points to be reflected on from this case, are discussed. CPD/Clinical Relevance: Numbness should be treated with a high degree of suspicion, with urgent imaging, biopsy and specialist histopathology staining being carried out to exclude malignancy.
A Palatal Myoepithelioma
Authors: Bains Amandeep , Dennis Thomas , Doumpiotis Dimtrios 
Published: July 2019

This case report demonstrates the management of a myoepithelioma in the minor salivary glands of the palate. Myoepitheliomas are rare, benign, salivary gland tumours which usually affect the parotid glands. The rare neoplasms only account for 1–1.5% of all salivary gland neoplasms. This case shows a minimal approach to treating this rare tumour found in a rare site. CPD/Clinical Relevance: This case demonstrates the potential for rapid epithelial recovery within the oral cavity.
Motivational interviewing in managing dental caries in children
Authors: Bhujel Nabina , Rajan Sadna 
Published: July 2019

Motivational Interviewing (MI) is a person-centred behavioural management technique that is valuable in prevention in healthcare including dentistry. This useful tool increases the motivation of patients and their carers and has been incorporated in the professional guidelines for the prevention of dental disease and also behavioural management. This review explores the relevance to the whole dental team in the promotion of oral health behaviour and discusses the relevant evidence related to dentistry. CPD/Clinical Relevance: All dental professionals who deliver prevention should understand the clinical relevance of using MI so that dental disease can be minimized with positive behaviour change in patients and their care-givers.
Desafios da regionalização na assistência à gestante e ao parto na V região de saúde, Garanhuns, Pernambuco.
Authors: Santos Maria Antonia da Silva , Cruz Jaciara Balbino da , Silva Valdemir Rodrigues da 
Published: July 2019

<!--	@page { margin: 2cm }	P { margin-bottom: 0.21cm }	-->	Regionalização da atenção a saúde surge pela necessidade de uma política de interiorização forte, como meio de garantir o acesso do usuário do SUS a serviços de qualidade, ao menor custo social,econômico e sanitário. Regionalizar não significa colocar vem segundo planos os deveres do municípios e sim a partir destes soma a uma rede horizontal de assistência integralizada da atenção .É um processo solidário participativo entre os três níveis federados, promovendo a auto suficiência da rede em atenção de média complexidade. Processo este iniciado pelo governo do estado de Pernambuco recentemente (2009/2010).O presente estudo visa demonstrar a real situação deste processo, a partir da análise da demanda de assistência na maternidade Regional (número de consultas, internamento e parto), constatando a falta de assistência a nível de municípios da V regional. Inclusive a cidade sede, que teoricamente, seria parâmetro comparativo pois, estar em melhores condições de desenvolvimento sócio econômico.
Potencialidades e Fragilidades da rede de atenção à saúde da mulher no município de Limoeiro
Authors: Oliveira Darlene , Ricarte Luana , Cristine Sandra 
Published: July 2019

<!--	@page { margin: 2cm }	P { margin-bottom: 0.21cm }	-->	O objetivo deste ensaio foi analisar as potencialidades e fragilidades da saúde da mulher no município de Limoeiro. Foram utilizados artigos publicados entre nas bases de dados Lilacs, Medline e BVS utilizando as palavras chaves "saúde da mulher", "rede de atenção básica" e suas versões em inglês, como também os dados do diagnóstico da rede de saúde da II regional de saúde elaborado pela Secretaria Estadual de Saúde de Pernambuco. Pôde-se perceber que a saúde da mulher no município de Limoeiro se resume aos cuidados do pré-natal de baixo e alto risco, citologia e exame de mama com solicitação de mamografia e USG mama além do encaminhamento aos especialistas.
Especialidades ofertadas pelos Centros de Especialidades Odontológicas em Recife, Pernambuco: notas preliminares
Authors: Luciano de Souza Valéria 
Published: July 2019

O objetivo desta pesquisa foi avaliar a estruturação dos Centros de Especialidades Odontológicas do Programa de Saúde Bucal na Cidade do Recife, através de uma investigação para registrar a quantidade de CEOs no município pesquisado, a distribuição geográfica dos mesmos e identificar os serviços oferecidos em cada uma dessas unidades especializadas Os dados foram coletados através da visita do pesquisador aos Centros de especialidades com o auxílio do instrumento de coleta de dados, um formulário tipo “check list” contendo as diversas especialidades que compõe os requisitos mínimos do Programa Brasil Sorridente. Após análise dos dados, concluiu-se que nenhum dos seis Centros de Especialidades Odontológicas da Cidade do Recife atende os requisitos mínimos exigidos pelo programa, que são: Diagnóstico bucal, Periodontia, Endodontia, Cirurgia Oral e Atendimento a pacientes com necessidades especiais.
Planejamento e programação de ações em saúde: conceitos, importância e suas influências na organização dos serviços de saúde bucal
Authors: Carnut Leonardo 
Published: July 2019

<!--	@page { margin: 2cm }	P { margin-bottom: 0.21cm }	-->	Estudos demonstram que o planejamento e a programação a nível local é uma prática pouco difundida no cotidiano das equipes de saúde bucal na estratégia de saúde da família. Especula-se que isso possa ser atribuído, em parte, ao caráter histórico do planejamento e da programação dos serviços de saúde pública no âmbito do processo de trabalho no setor saúde. Este ensaio objetivou revisar os aspectos histórico-conceituais do planejamento e da programação no setor saúde com foco na saúde bucal. Percebeu-se que muitos desafios estão relacionados ao uso de planejamento e, por conseqüência da programação das ações em saúde, dentre elas estão o uso da informação em saúde como insumo para o planejamento, a delimitação conceitual imprecisa de termos relacionados ao planejamento e a programação como também uma inserção incipiente do planejamento nos programas de saúde bucal. Por fim, concluiu-se que o planejamento e a programação em saúde bucal apresentam limitações nos dias atuais e um componente histórico pode ser atribuído como determinante dessa situação.
Solar irradiation as an alternative bleaching process for agar extracted from Gracilariopsis heteroclada in Iloilo, Philippines
Authors: Endoma Leonilo F. , Nacional Loda M. , Luhan Rovilla J. 
Published: July 2019

Abstract
The current industrial practice of using chemical bleach to achieve the pure white colour of agar is deleterious to both human and environmental health. This study evaluates the potential of solar irradiation as an alternative bleaching process for agar extracted from Gracilariopsis heteroclada in Iloilo, Philippines. The physico-chemical properties of agar obtained from alkaline-treated seaweed after exposure to different bleaching conditions (e.g. solar irradiation, hypochlorite solution, and ultraviolet and fluorescent lights) were examined and compared with commercial bacteriological agar. Photobleaching through solar irradiation produced agar with superior gel strength (1038.61 g cm−2), high 3,6-anhydrogalactose content (41.44%) and low total inorganic sulphate content (1.87%) without compromising agar yield (19.37%). Solar irradiation offers very promising results as a simple, low-cost, environmentally friendly alternative to the chlorine bleaching process for agar extraction.
The crystal structure of 4-(pyren-1-yl)butyl-3-nitrobenzoate, C27H21NO4
Authors: Barrientos Claudio , Barahona Patricia , Guevara Juan Luis , Squella J. Arturo , Moris Silvana 
Published: July 2019

AbstractC27H21NO4, triclinic,P1̄ (no. 2),a= 8.1182(5) Å,b= 9.0097(5) Å,c= 14.8013(10) Å,α= 72.603(2)°,β= 82.642(2)°,γ= 79.351(3)°,V= 1012.23(11) Å3,Z= 2,Rgt(F) = 0.0367,wRref(F2) = 0.1018,T= 150 K.
Using Microtechnology to Quantify Torso Angle During Match-Play in Field Hockey
Authors: Warman Geoffrey E. , Cole Michael H. , Johnston Rich D. , Chalkley Daniel , Pepping Gert-Jan 
Published: July 2019

Abstract
Warman, GE, Cole, MH, Johnston, RD, Chalkley, D, and Pepping, GJ. Using microtechnology to quantify torso angle during match-play in field hockey. J Strength Cond Res 33(10): 2648–2654, 2019—Field hockey is played in a dynamic environment placing specific postural demands on athletes. Little research has been devoted to understanding the nature of a player's torso postures in field hockey match-play and its relationship with the perceptuomotor demands of the sport. We used commercially available microtechnology worn by 16 athletes during a 6-match national tournament to quantify torso flexion/extension angles. Orientation was derived using the inertial and magnetic sensors housed within global positioning system devices, assessing torso angle in the sagittal plane from 91 individual match files. The main independent variable was playing position, whereas the dependent variable was torso flexion/extension, presented as a percentage of playing time spent in 15 × 10° torso postural bands ranging from ≥40° extension to ≥90° flexion. It was shown that athletes spent 89.26% of their playing time in various torso postures, ranging from 20 to 90° of flexion. Defenders spent more time than midfielders (p = 0.004, effect size [ES] = 0.43) and strikers (p = 0.004; ES = 0.44) in the posture band of 10–20° torso flexion, whereas midfielders spent more time between 20 and 30° of torso flexion (p = 0.05; ES = 0.32) than strikers. Conversely, strikers spent more time between 30 and 40° of flexion than defenders (p < 0.001; ES = 0.74). These results reflect the sport-specific and role-specific torso angles adopted by field hockey athletes during match-play. Coaching staff can use these data to gain insight into the postural demands of their sport and inform the preparation of athletes for the perception-action demands of competition.