bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data-Driven Reliable Facility Location Design
Authors: Shen Hao , Xue Mengying , Shen Zuo-Jun Max 
Published: December 2024

We study the reliable (uncapacitated) facility location (RFL) problem in a data-driven environment where historical observations of random demands and disruptions are available. Owing to the combinatorial optimization nature of the RFL problem and the mixed-binary randomness of parameters therein, the state-of-the-art RFL models applied to the data-driven setting either suggest overly conservative solutions or become computationally prohibitive for large- or even moderate-size problems. In this paper, we address the RFL problem by presenting an innovative prescriptive model aiming to balance solution conservatism with computational efficiency. In particular, our model selects facility locations to minimize the fixed costs plus the expected operating costs approximated by a tractable data-driven estimator, which equals to a probabilistic upper bound on the intractable Kolmogorov distributionally robust optimization estimator. The solution of our model is obtained by solving a mixed-integer linear program that does not scale in the training data size. Our approach is proved to be asymptotically optimal, and offers a theoretical guarantee for its out-of-sample performance in situations with limited data. In addition, we discuss the adaptation of our approach when facing data with covariate information. Numerical results demonstrate that our model significantly outperforms several important RFL models with respect to both in-sample and out-of-sample performances as well as computational efficiency. This paper was accepted by Chung Piaw Teo, optimization. Funding: H. Shen acknowledges the support from the National Natural Science Foundation of China [Grants 72371240, 72001206]. M. Xue acknowledges the support from the National Natural Science Foundation of China [Grant 72201257]. Z.J. M. Shen acknowledges the support from National Natural Science Foundation of China [Grant 71991462], Hong Kong ITC Mainland-Hong Kong Joint Funding Scheme [MHP/192/23], and RGC Theme-based Research Scheme [T32-707/22-N]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.02115 .
Chyle leak following root of mesentery dissection in pancreaticoduodenectomy with inferior infracolic superior mesenteric artery first approach
Authors: Maharjan Prabir , Regmee Sujan , Adhikari Spandan D , Pahari Rabin , Ghimire Roshan , Maharjan Dhiresh K , Shrestha Suman K , Thapa Prabin B 
Published: December 2024

BACKGROUND
The root of mesentery dissection is one of the critical maneuvers, especially in borderline resectable pancreatic head cancer. Intra-abdominal chyle leak (CL) including chylous ascites may ensue in up to 10% of patients after pancreatic resections. Globally recognized superior mesenteric artery (SMA) first approaches are invariably performed. The mesenteric dissection through the inferior infracolic approach has been discussed in this study emphasizing its post-operative impact on CL which is the cornerstone of this study.
AIM
To assess incidence, risk factors, clinical impact of CL following root of mesentery dissection, and the different treatment modalities.
METHODS
This is a retrospective study incorporating the patients who underwent dissection of the root of mesentery with inferior infracolic SMA first approach pancreatoduodenectomy for the ventral body and uncinate mass of pancreas in the Department of Gastrointestinal and General Surgery of Kathmandu Medical College and Teaching Hospital from January 1, 2021 to February 28, 2024. Intraoperative findings and postoperative outcomes were analyzed.
RESULTS
In three years, ten patients underwent root of mesentery dissection with inferior infracolic SMA first approach pancreatoduodenectomy. The mean age was 67.6 years with a male-to-female ratio of 4:5. CL was seen in four patients. With virtue of CL, Clavien-Dindo grade II or higher morbidity was observed in four patients. Two patients had a hospital stay of more than 20 days with the former having a delayed gastric emptying and the latter with long-term total parenteral nutrition requirement. The mean operative time was 330 minutes. Curative resection was achieved in 100% of the patients. The mean duration of the intensive care unit and hospital stay were 2.55 ± 1.45 days and 15.7 ± 5.32 days, respectively.
CONCLUSION
Root of mesentery dissection with lymphadenectomy and vascular resection correlated with occurrence of CL. After complete curative resection, these were managed with total parenteral nutrition without adversely impacting outcome.
Herpes simplex virus 2-induced aseptic meningitis presenting with sudden deafness: A case report
Authors: Liu Yuan-Cheng , Hsiao Shih-Hsuan , Chen Peir-Rong 
Published: December 2024

BACKGROUND
Aseptic meningitis is defined as meningeal inflammation caused by various etiologies with negative cerebrospinal fluid (CSF) bacterial culture. The most common etiologies are viruses [enteroviruses, arboviruses, and herpes simplex virus type 2 (HSV-2)]. Aseptic meningitis can have various presentations, including sensorineural deafness. While sensorineural deafness from mumps meningoencephalitis has been reported, cases of HSV-2-induced hearing loss are rare. Herein, we report a case of HSV-2-induced meningitis that presented with sudden deafness.
CASE SUMMARY
A 68-year-old man experienced a profound sudden onset of left-sided hearing loss for one day. Pure-tone audiograms demonstrated sudden left-sided sensorineural hearing loss (thresholds 80-90 dB). After treatment with high-dose steroids for 1 week, he experienced an acute consciousness change with left hemiparesis. The laboratory data showed no significant abnormalities. Brain computed tomography without contrast and magnetic resonance imaging revealed no intracranial hemorrhage or obvious brain lesion. The CSF analysis and the Multiplex PCR panels showed HSV-2 positivity. Hence, under the diagnosis of herpes meningoencephalitis, acyclovir was prescribed and his symptoms gradually resolved.
CONCLUSION
This case report further demonstrates that a viral infection could be a cause of sudden sensorineural hearing loss.
Describing randomization in trials included in systematic reviews in orthopaedic surgery
Authors: Tang Matthew , Lun Kimberley K. , Lewin Adriane M. , Harris Ian A. 
Published: December 2024

AimsSystematic reviews of randomized controlled trials (RCTs) are the highest level of evidence used to inform patient care. However, it has been suggested that the quality of randomization in RCTs in orthopaedic surgery may be low. This study aims to describe the quality of randomization in trials included in systematic reviews in orthopaedic surgery.MethodsSystematic reviews of RCTs testing orthopaedic procedures published in 2022 were extracted from PubMed, Embase, and the Cochrane Library. A random sample of 100 systematic reviews was selected, and all included RCTs were retrieved. To be eligible for inclusion, systematic reviews must have tested an orthopaedic procedure as the primary intervention, included at least one study identified as a RCT, been published in 2022 in English, and included human clinical trials. The Cochrane Risk of Bias-2 Tool was used to assess random sequence generation as ‘adequate’, ‘inadequate’, or ‘no information’; we then calculated the proportion of trials in each category. We also collected data to test the association between these categories and characteristics of the RCTs and systematic reviews.ResultsWe included 917 unique RCTs. We found that 374 RCTs (40.8%) reported adequate sequence generation, 61 (6.7%) were inadequate, 410 (44.7%) lacked information, and 72 (7.9%) were observational studies incorrectly included as RCTs within the systematic review. Publication year, an author with statistical or epidemiological qualifications, and journal impact factor were each associated with adequate randomization. We found that 45 systematic reviews (45%) included at least one inadequately randomized RCT or an observational study incorrectly treated as a RCT.ConclusionThere is evidence of a lack of random allocation in RCTs included in systematic reviews in orthopaedic surgery. The conduct of RCTs and systematic reviews should be improved to minimize the risk of bias from inadequate randomization in RCTs and mislabelling of non-randomized studies as RCTs.Cite this article: Bone Jt Open 2024;5(12):1072–1080.
Transformative Power of Music in the World of Dennis Hopper
Authors: Buakong Bronwynn 
Published: December 2024

Review of: Transformative Power of Music in the World of Dennis Hopper

Music and Sound in the Films of Dennis Hopper, Stephen Lee Naish (2024)
New York: Routledge, 92pp., ISBN: 9781032737690 (hbk), $66.99
Proposta de integração das técnicas e abordagens da manufatura enxuta e da teoria das restrições na redução do lead time de uma linha de montagem
Authors: Puerta Marcus Vinicius , Franco Bruno Chaves , Melo Julio Cesar , Muniz Junior Jorge 
Published: December 2024

O grande número de competidores globais tem levado a indústria automotiva a buscarem melhorias na gestão operacional. Esse trabalho apresenta uma proposta de integração das técnicas e abordagens da Manufatura Enxuta e da Teoria das Restrições, através de uma aplicação prática, visando a redução do lead time de uma linha de montagem de chassis. Em uma primeira etapa foram apresentados os conceitos e as possibilidades de integração de ambas as teorias e, a partir de um diagnóstico inicial do sistema de abastecimento, foram propostas alterações, de maneira evolutiva, em que melhorias baseadas na Manufatura Enxuta eram implementadas a cada rodada de experimento, culminando com a implementação de melhorias baseadas na Teoria das Restrições, integrando ambos os conceitos. O resultado final obtido corrobora a eficiência da integração das duas abordagens para a melhoria de processos, as quais contribuíram para uma diminuição dos tempos de ciclo de abastecimento na ordem de 89% para a célula alvo estudada, sendo superior ao resultado obtido utilizando-se apenas uma das técnicas, sem que houvesse necessidade de investimentos e/ou despesas significativas.
Studi Poliembrio Biji Jeruk Sambal (Citrus x amblycarpa (Haask.) Osche) Sebagai Batang Bawah
Authors: Sari Herlinda , Iriani Dyah 
Published: December 2024

Citrus x amblycarpa sering dimanfaatkan oleh masyarakat di Kecamatan Lubuk Alung, Kabupaten Padang Pariaman, Sumatera Barat, sebagai batang bawah karena toleran terhadap Citrus Tristeza Virus (CTV). Penelitian ini bertujuan untuk mempelajari tingkat poliembrioni biji jeruk sambal dan mengamati viabilitas biji dan vigor bibit jeruk sambal. Penelitian dilakukan dengan mengamati jumlah embrio menggunakan mikroskop dan dengan penyemaian biji. Ekstraksi biji dan pengamatan dilakukan di Laboratorium Botani Jurusan Biologi FMIPA Universitas Riau. Penyemaian biji dilakukan di Jalan Kubang Jaya, Pekanbaru. Hasil penelitian ini menunjukkan persentase poliembrioni biji jeruk sambal pada pengamatan mikroskopis sebesar 27,85% dan pada biji monoembrioni sebesar 72,14%. Hasil semaian menunjukkan persentase multiple seedling sebesar 14%, semaian tunggal 75,33%, dan bibit mati 10,66%. Rerata laju perkecambahan biji jeruk sambal paling cepat (9,3 hari) dan paling lambat (12,2 hari). Indeks kecepatan perkecambahan paling cepat pada kategori bobot buah kecil yaitu 6,4 dengan laju perkecambahan 12,2 hari. Rerata tinggi bibit, jumlah daun, panjang akar tertinggi dihasilkan oleh bobot buah besar dengan rerata tinggi bibit sebesar 7,21cm±2,33; jumlah daun sebesar 2,64 helai± 0,71; panjang akar tunggang sebesar 4,38 cm±1,9; dan jumlah akar cabang sebesar 2,8±1,31. Biji jeruk sambal bersifat poliembrioni dan persentase perkecambahan sebesar 89,33%, rerata persentase poliembrioni sebesar 15,66%. Jeruk sambal always used by the community in Lubuk Alung District, Padang Pariaman Regency, West Sumatra, as a rootstock because it’s tolerant to Citrus Tristeza Virus (CTV). This research aims to study the level of polyembryony in chili orange seeds and observe seed viability and vigor of chili orange seedlings. This research was carried out by observing the number of embryos using a microscope and observing the number of embryos by sowing seeds. Seed extraction and observations were carried out at the Botany Laboratory, Biologi Department, FMIPA, Riau University. Seed sowing is carried out on Kubang Jaya, Pekanbaru.The results of this story showed that the percentage of polyembryonic chili orange seeds on microscopic observations was 27.85% and that of monoembryonic seeds were 72.14%. The Seedling results showed that the percentage of multiple seedlings was 14%, single seedlings were 75.33%, and dead seedlings were 10.66%. The germination rate was the fastest (9.3 days) and the slowest (12.2 days). The fastest germination speed index in the small fruit weight category is 6.4 with a germination rate of 12.2 day The highest average seed height, number of leaves, root length was produced by large fruit weight with an average seed height is 7.21cm ± 2.33; number of leaves of 2.64 ± 0.71; tap root length of 4.38cm ± 1.9; and the number of branch roots was 2.8 ± 1.31. Chili oranges seeds are polyembryonic and the germination percentage is 89.33%, the average polyembryonic percentage is 15.66%.
Respon Pertumbuhan Vegetatif dan Pembungaan Tanaman Cabai Merah Keriting (Capsicum annum L. cv. Jacko) pada Aplikasi Rasio Konsentrasi BAP dan GA3 Setelah Pemangkasan Pucuk
Authors: Saptiningsih Endang , Ardiyanti Ardiyanti , Suedy Sri Widodo Agung , Darmanti Sri 
Published: December 2024

Pertumbuhan dan produksi cabai dapat ditingkatkan melalui metode pemangkasan pucuk. Aplikasi BAP dan GA3 setelah pemangkasan pucuk dapat mempengaruhi pertumbuhan vegetatif tanaman yang selanjutnya berdampak terhadap pembungaan dan produksi cabai. Penelitian ini bertujuan untuk mengkaji pengaruh aplikasi hormon BAP dan GA3 dengan berbagai rasio konsentrasi setelah pemangkasan pucuk terhadap pertumbuhan vegetatif dan pembungaan tanaman cabai merah keriting (Capsicum annuum L.). Pemangkasan pucuk dilakukan pada fase vegetatif akhir, diikuti dengan aplikasi BAP dan GA3. Parameter yang diamati meliputi durasi muncul tunas cabang lateral, jumlah dan panjang cabang lateral, luas daun, kandungan klorofil total, alokasi biomassa, dan periode muncul bunga. Hasil penelitian menunjukkan bahwa aplikasi rasio konsentrasi BAP dan GA3 secara signifikan meningkatkan jumlah dan panjang cabang lateral, luas daun, dan mempercepat waktu muncul bunga dibandingkan kontrol. Perlakuan dengan rasio konsentrasi BAP 0 ppm : GA3 100 ppm dan BAP 200 ppm : GA3 100 ppm memberikan hasil terbaik dalam pertumbuhan vegetatif dan mempercepat pembungaan. Penelitian ini memberikan kontribusi dalam pengelolaan hormon tanaman pasca pemangkasan untuk meningkatkan produktivitas cabai. The growth and yield of chili peppers can be enhanced through the method of shoot pruning. The application of BAP and GA3 after shoot pruning can affect the vegetative growth of plants, which subsequently impacts the flowering and production of chili peppers. This study aims to examine the effects of applying BAP and GA3 hormones at various concentration ratios after shoot pruning on the vegetative growth and flowering of curly red chili peppers (Capsicum annuum L.). Shoot pruning was carried out at the late vegetative phase, followed by the application of BAP and GA3. The observed parameters included the duration of lateral bud emergence, the number and length of lateral branches, leaf area, total chlorophyll content, biomass allocation, and the flowering period. The results showed that the application of BAP and GA3 concentration ratios significantly increased the number and length of lateral branches, leaf area, and accelerated the flowering time compared to the control. Treatments with the ratios of BAP 0 ppm : GA3 100 ppm and BAP 200 ppm : GA3 100 ppm yielded the best results in vegetative growth and accelerated flowering. This study contributes to the management of plant hormones post-pruning to enhance chili productivity.
Pertumbuhan dan Kandungan Klorofil Mangrove Rhizophora Stylosa Griff pada Salinitas yang Berbeda
Authors: Hastuti Endah , Niti Mahatma Narendra , Prihastanti Erma 
Published: December 2024

Permasalahan yang dialami vegetasi mangrove adalah populasinya yang kian menyusut drastis. Pengujian pertumbuhan dan kandungan klorofil R. stylosa harus dilakukan agar proses rehabilitasi di alam liar bisa sesuai dengan kondisi salinitas yang ada. Penelitian ini dilakukan dengan Rancangan Acak Lengkap (RAL). Penanaman R. stylosa dilakukan menggunakan ember yang diberi larutan salinitas dengan variasi: 15 ppt, 20 ppt, 25 ppt, dan 30 ppt masing-masing tiga kali ulangan. Parameter penelitian adalah: diameter batang, tinggi batang, jumlah daun, luas daun, dan kandungan klorofil. Data dianalisis dengan ANOVA, apabila terdapat perbedaan nyata maka dilakukan uji DMRT dengan kepercayaan 95%. Hasil ANOVA menunjukkan bahwa tidak ada perbedaan nyata antar perlakuan pada pertumbuhan diameter batang, tinggi batang, jumlah daun, dan luas daun, namun terdapat kecenderungan hasil terbaik terdapat pada salinitas 15 ppt dengan diameter batang (1,68 mm2), tinggi batang (15,53 cm), jumlah daun (5,33), dan luas daun (1650,79 mm2). Hasil uji ANOVA pada kandungan klorofil menunjukkan bahwa terdapat perbedaan nyata antar perlakuan. Hasil uji DMRT menunjukkan bahwa kandungan klorofil paling tinggi terdapat pada salinitas 15 ppt (11,015 mg/L). The problem experienced by mangrove vegetation is that its population is decreasing drastically. Testing of the growth and chlorophyll content of R. stylosa must be carried out so that the rehabilitation process in the wild can be in accordance with existing salinity conditions. This research was conducted in a completely randomised design (CRD). Planting of R. stylosa was done using a bucket that was given a salinity solution with variations: 15 ppt, 20 ppt, 25 ppt, and 30 ppt each with three replications. The research parameters were stem diameter, stem height, number of leaves, leaf area, and chlorophyll content. Data were analysed by ANOVA, if there were significant differences then DMRT test was conducted with 95% confidence. ANOVA results showed that there were no significant differences between treatments on the growth of stem diameter, stem height, number of leaves, and leaf area, but there was a tendency that the best results were in 15 ppt salinity with stem diameter (1.68 mm2), stem height (15.53 cm), number of leaves (5.33), and leaf area (1650.79 mm2). ANOVA test results on chlorophyll content showed that there were significant differences between treatments. The DMRT test results showed that the highest chlorophyll content was found at 15 ppt salinity (11.015 mg/L).
Intrauterine fetal growth restriction in sheep leads to sexually dimorphic programming of Preadipocytes' differentiation potential
Authors: Goyal Michell , Luna Ramirez Rosa I. , Limesand Sean W. , Goyal Ravi 
Published: December 2024

AbstractFetal growth restriction (FGR) is a risk factor for obesity in adult life. Importantly, growth‐restricted females are more prone to obesity than males. The mechanisms involved in this sexually dimorphic programming are not known. Previously, we have demonstrated that ambient hyperthermia (40°C) led to placental insufficiency and significant FGR, and the perirenal adipose tissue undergoes sexually dimorphic gene expression. We demonstrated that males undergo significant changes in gene expression with growth restriction. This was not the case in females. We have also demonstrated that the isolated preadipocytes from male FGR (MFGR) have reduced differentiation potential compared to control males & females and female FGR (FFGR). Thus, we hypothesized that growth restriction differentially programs gene expression and genetic pathways in perirenal preadipocytes, which reduces their differentiation potential in male fetuses in a sexually dimorphic manner. We created FGR by exposing pregnant sheep to ambient hyperthermia. After isolating preadipocytes from perirenal adipose tissue, we differentiated them following published protocols. We examined the gene expression before and after differentiation from control male, control female, MFGR, and FFGR female. We also compared our data with other published studies in mouse and human preadipocytes. Our results demonstrate that a set of 21 genes altered with preadipocyte differentiation to mature adipocytes is common in adipose tissue from both sexes, humans, mice, and sheep, at different organismal ages (embryonic, fetal, and adult) and different sites (subcutaneous inguinal, pancreatic, perirenal). We also demonstrate that female FFGR fetuses demonstrate all these 21 genes altered similar to control males and females; however, MFGR fetuses have six genes (Dgat2, Fabp4, Lipe, Lrrfip1, Spred3, and Thrsp) that are not changed with preadipocyte differentiation to mature adipocyte. These genes may be responsible for reduced differentiation potential and obesity in FGR males compared to FGR females. Another important finding of the present study is that Lrrfip1, known to be associated with obesity, was upregulated with FGR and requires further investigation. Overall, our studies provide several target genes that may play a crucial role in reducing the risk of MFGR for obesity.
The modified quasi-boundary-value method for an ill-posed generalized elliptic problem
Authors: Selmani Wissame , Boussetila Nadjib , Kirane Mokhtar , Alsulami Hamed 
Published: December 2024

Abstract
In this study, we are interested in the regularization of an ill-posed problem generated by a generalized elliptic equation in an abstract framework. The regularization strategy is based on the modified quasi-boundary-valued method, which allows us to construct a stable solution depending on a small parameter

ε

\varepsilon

. To justify the theoretical results obtained, we present a few numerical examples to demonstrate the accuracy of the approximate solution and the effectiveness of the method used in our investigation.
A note on 1-semi-greedy bases in p-Banach spaces with 0 < p ≤ 1
Authors: Berná Pablo M. , García Andrea , González David 
Published: December 2024

Abstract
The purpose of this article is to discuss about the so-called semi-greedy bases in

p

p

-Banach spaces. Specifically, we will review existing results that characterize these bases in terms of almost-greedy bases, and, also, we analyze quantitatively the behavior of certain constants. As new results, by avoiding the use of certain classical results in

p

p

-convexity, we aim to quantitatively improve specific bounds for bi-monotone 1-semi-greedy bases.