bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombus Volume as a Predictor of Nonrecanalization After Intravenous Thrombolysis in Acute Stroke
Authors: Yoo Joonsang , Baek Jang-Hyun , Park Hyungjong , Song Dongbeom , Kim Kyoungsub , Hwang In Gun , Kim Young Dae , Kim Seo Hyun , Lee Hye Sun , Ahn Seong Hwan , Cho Han-Jin , Kim Gyu Sik , Kim Jinkwon , Lee Kyung-Yul , Song Tae-Jin , Choi Hye-Yeon , Nam Hyo Suk , Heo Ji Hoe 
Published: September 2018

Background and Purpose—
We investigated whether measuring the volume and density of a thrombus could predict nonrecanalization after intravenous thrombolysis.

Methods—
This study included a retrospective cohort to develop a computed tomography marker of thrombus for predicting nonrecanalization after intravenous thrombolysis and a prospective multicenter cohort for validation of this marker. The volume and density of thrombus were measured semiautomatically using 3-dimensional software on a baseline thin-section noncontrast computed tomography (1 or 1.25 mm). Recanalization was assessed on computed tomography angiography or magnetic resonance angiography immediately after intravenous thrombolysis or conventional angiography in patients who underwent further intra-arterial treatment. Nonrecanalization was defined as a modified Thrombolysis in Cerebral Infarction grade 0, 1, 2a.

Results—

In the retrospective cohort, 162 of 214 patients (76.7%) failed to achieve recanalization. The thrombus volume was significantly larger in patients with nonrecanalization than in those with successful recanalization (149.5±127.6 versus 65.3±58.3 mm
3
;
P
<0.001). In the multivariate analysis, thrombus volume was independently associated with nonrecanalization (
P
<0.001). The cutoff for predicting nonrecanalization was calculated as 200 mm
3
. In the prospective multicenter validation study, none of the patients with a thrombus volume ≥200 mm
3
among 78 enrolled patients achieved successful recanalization. The positive and negative predictive values were 95.5 and 29.4 in the retrospective cohort 100 and 23.3 in the prospective validation cohort, respectively. The thrombus density was not associated with nonrecanalization.

Conclusions—
Thrombus volume was predictive of nonrecanalization after intravenous thrombolysis. Measurement of thrombus volume may help in determining the recanalization strategy and perhaps identify patients suitable for direct endovascular thrombectomy.
Elevated International Normalized Ratio Is Associated With Ruptured Aneurysms
Authors: Can Anil , Castro Victor M. , Dligach Dmitriy , Finan Sean , Yu Sheng , Gainer Vivian , Shadick Nancy A. , Savova Guergana , Murphy Shawn , Cai Tianxi , Weiss Scott T. , Du Rose 
Published: September 2018

Background and Purpose—
The effects of anticoagulation therapy and elevated international normalized ratio (INR) values on the risk of aneurysmal subarachnoid hemorrhage are unknown. We aimed to investigate the association between anticoagulation therapy, elevated INR values, and rupture of intracranial aneurysms.

Methods—
We conducted a case-control study of 4696 patients with 6403 intracranial aneurysms, including 1198 prospective patients, diagnosed at the Massachusetts General Hospital and the Brigham and Women’s Hospital between 1990 and 2016 who were on no anticoagulant therapy or on warfarin for anticoagulation. Patients were divided into ruptured and nonruptured groups. Univariable and multivariable logistic regression analyses were performed to evaluate the association of anticoagulation therapy, INR values, and presentation with a ruptured intracranial aneurysm, taking into account the interaction between anticoagulant use and INR. Inverse probability weighting using propensity scores was used to minimize differences in baseline demographics characteristics. The marginal effects of anticoagulant use on rupture risk stratified by INR values were calculated.

Results—
In unweighted and weighted multivariable analyses, elevated INR values were significantly associated with rupture status among patients who were not anticoagulated (unweighted odds ratio, 22.78; 95% CI, 10.85–47.81 and weighted odds ratio, 28.16; 95% CI, 12.44–63.77). In anticoagulated patients, warfarin use interacts significantly with INR when INR ≥1.2 by decreasing the effects of INR on rupture risk.

Conclusions—
INR elevation is associated with intracranial aneurysm rupture, but the effects may be moderated by warfarin. INR values should, therefore, be taken into consideration when counseling patients with intracranial aneurysms.
The Preparation of Palygorskite Clay Modified Woodceramics from Wheat Straw and the Absorption of Them to the Phenol Wastewater
Authors: Wu W.T. , Nie Z.F. , Tan F.I. , Xu F. , Xu L. , Gao K.I. 
Published: September 2018

This paper used wheat straw and palygorskite clay as raw materials, and phenolic resin as adhesive. By the technologies of powdering, mixing, solidifying, molding and sintering, the palygorskite clay Modified woodceramics were obtained. And it made use of these porous composite materials to research the adsorption of the phenol wastewater, which explored the adsorption effect of the composite materials on phenol and found out the optimum conditions of adsorption by changing the ratio of raw materials, sintering temperature, dosage of composite materials, oscillating time and pH. The result of the palygorskite clay Modified woodceramics prepared by different dosing ration of raw materials and sintering temperatures on phenol showed that the removal effect of the composite materials (wheat straw: palygorskite clay=5:1, sintering temperature = 900 °C) on phenol was best. Using the palygorskite clay modified woodceramics to adsorb the phenol wastewater. It turned out that when the dosage of the composite materials was 0.5 g, the Oscillating time was 60 mins, and the solution temperature was 25 °C, the composite materials adsorption efficiency on phenol was the highest. In addition, the higher the phenol solution concentration and pH, the lower the adsorption efficiency was. What's more, the absorbability of the composite materials on phenol corresponded with Feundlich adsorption model, and the saturated adsorption was 45.66 mg/L, which indicated that the palygorskite clay Modified woodceramics had strong adsorption effect to phenol.
An Evaluation of the Compression Response of High-Performance Prepregs for Afp Applications
Authors: Rao S. , Umer R. , Cantwell W.J. 
Published: September 2018

In this study, the compaction response of unidirectional out-of-an autoclave (OOA) prepreg tape has been evaluated experimentally at 25°, 45° and 65 °C. Instantaneous and incremental displacement compaction experiments have been carried out in a universal testing machine until a compressive strain of 0.42 ±0.02 was achieved. The fiber-bed stress was determined by transposing the results of displacement-controlled experiments onto data from corresponding load-controlled experiments. The material was then modelled as a viscoelastic material using a third order exponential decay function, based on a generalized Maxwell model. This procedure enabled the extraction of the relaxation time constants and the peak stress. The results highlight a linear relationship between the operating temperature and the load/stress relaxation response of the prepreg/tape, suggesting that if the fiber placement procedure is performed at 65 °C, the effect of roller stiffness on tape/fiber laying is negligible. The maximum contribution of fiber stress to the overall relaxation is approximately 6% at 45 °C and 65 °C, indicating the formability to be matrix dependent. A minimum spring-back is observed in specimens that were tested under incremental displacement conditions. The difference in thickness of the as-laid laminate and the cured laminate at 45 °C and 65 °C were similar. The linear stress relaxation model has been shown to be capable of predicting the maximum stress accurately using the viscosity values of the dashpots and the moduli of the springs.
MicroRNA-325 Is a Potential Biomarker and Tumor Regulator in Human Bladder Cancer
Authors: Lin Tao , Zhou Shiming , Gao Hui , Li Yuqiao , Sun Lijiang 
Published: September 2018

Purpose: We evaluated whether human microRNA-325 may be a potential biomarker and tumor regulator in bladder cancer. Methods: Human microRNA-325 expression was probed by quantitative real-time polymerase chain reaction in both in vitro bladder cancer cell lines and in vivo bladder carcinoma tissues retrieved from patients with cancer. The prognostic potential of human microRNA-325 in predicting postoperative overall survival of patients with bladder cancer was estimated. Endogenous human microRNA-325 was overexpressed by lentiviral transduction in bladder cancer cell lines, T24 and 5637 cells. The tumor regulatory effects of human microRNA-325 upregulation on T24 and 5637 cells were evaluated both in vitro and in vivo. Results: Human microRNA-325 was aberrantly downregulated in both bladder cell lines and human bladder carcinomas. Lowly expressed human microRNA-325 in bladder carcinoma was closely associated with poor postoperative overall survival of patients with cancer. In T24 and 5637 cells, virally transduced cells had markedly upregulated human microRNA-325 expressions. Biochemical assays demonstrated that human microRNA-325 upregulation in bladder cancer had tumor-suppressive functions by decreasing cancer proliferation, cisplatin chemoresistance, and cancer migration in vitro and hindering transplantation growth in vivo and cell cycle transition. Conclusion: Human microRNA-325 is lowly expressed and may serve as a potential prognostic biomarker in human bladder cancer. After further validation, human microRNA-325 may be a novel therapeutic target for suppressing carcinoma in patients with bladder cancer.
X-ray diffraction Warren–Averbach mullite analysis in whiteware porcelains: influence of kaolin raw material
Authors: Sanz Angel , Bastida Joaquín , Caballero Angel , Kojdecki Marek 
Published: September 2018

ABSTRACTCompositional and microstructural analysis of mullites in porcelain whitewares obtained by the firing of two blends of identical triaxial composition using a kaolin B consisting of ‘higher-crystallinity’ kaolinite or a finer halloysitic kaolin M of lower crystal order was performed. No significant changes in the average Al2O3 contents (near the stoichiometric composition 3:2) of the mullites were observed. Fast and slow firing at the same temperature using B or M kaolin yielded different mullite contents. The Warren–Averbach method showed increase of the D110 mullite crystallite size and crystallite size distributions with small shifts to greater values with increasing firing temperature for the same type of firing (slow or fast) using the same kaolin, as well as significant differences between fast and slow firing of the same blend at different temperatures for each kaolin. The higher maximum frequency distribution of crystallite size observed at the same firing temperature using blends with M kaolin suggests a clearer crystallite growth of mullite in this blend. The agreement between thickening perpendicular to prism faces and mean crystallite sizes <D110> of mullite were not always observed because the direction perpendicular to 110 planes is not preferred for growth.
Five-year follow-up of lenalidomide plus rituximab as initial treatment of mantle cell lymphoma
Authors: Ruan Jia , Martin Peter , Christos Paul , Cerchietti Leandro , Tam Wayne , Shah Bijal , Schuster Stephen J. , Rodriguez Amelyn , Hyman David , Calvo-Vidal Maria Nieves , Smith Sonali M. , Svoboda Jakub , Furman Richard R. , Coleman Morton , Leonard John P. 
Published: September 2018

Key PointsLenalidomide plus rituximab as induction and maintenance therapy for MCL can achieve durable MRD-negative complete remissions. Chronic therapy–associated adverse events are generally nonaccumulative and remain manageable.
Pedobarographic and stabilometric analysis and exercises for children with recurrent ankle haemarthrosis
Authors: Elnaggar Ragab Kamal 
Published: September 2018

Background/Aims:To investigate the dynamic plantar loading characteristics, postural stability and the effectiveness of an exercise programme in children with recurrent ankle haemarthrosis.Methods:In an exploratory study, 56 children with haemophilia (Group A) and 23 typically developing children (Group B) were initially assessed. Group A received a progressive exercise programme twice a week for 6 weeks in succession. Midstance plantar loading and the dynamic limit of stability were measured using Tekscan HR MatTMpressure measurement system and Biodex Balance System respectively.Findings:Heel pressure in Group A was significantly lower than Group B (P<0.05), whereas mid-foot, forefoot, and hallux pressure were significantly higher (P<0.05). Also, Group A showed poorer postural stability (P<0.05). Furthermore, a significant correlation between postural stability and plantar loading measures was indicated in Group A. Following the completion of 6 weeks of exercises, the plantar pressure (except the medial mid-foot) and postural stability (except the mediolateral stability) for Group A were not significantly different in comparison to Group B (P>0.05).Conclusion:Dynamic plantar loading provides a potentially valuable directory for the clinicians to understand variations of postural stability in children with ankle haemarthrosis. Further, adherence to a 6-week exercise rehabilitation programme might be helpful.
Gray Method for Multiple Attribute Decision Making with Incomplete Weight Information under the Pythagorean Fuzzy Setting
Authors: Khan Muhammad Sajjad Ali , Abdullah Saleem , Lui Peide 
Published: September 2018

Abstract
In this study, we developed an approach to investigate multiple attribute group decision-making (MAGDM) problems, in which the attribute values take the form of Pythagorean fuzzy numbers whose information about attribute weights is incompletely known. First, the Pythagorean fuzzy Choquet integral geometric operator is utilized to aggregate the given decision information to obtain the overall preference value of each alternative by experts. In order to obtain the weight vector of the criteria, an optimization model based on the basic ideal of the traditional gray relational analysis method is established, and the calculation steps for solving Pythagorean fuzzy MAGDM problems with incompletely known weight information are given. The degree of gray relation between every alternative and positive-ideal solution and negative-ideal solution is calculated. Then, a relative relational degree is defined to determine the ranking order of all alternatives by calculating the degree of gray relation to both the positive-ideal solution and negative-ideal solution simultaneously. Finally, an illustrative example is given to verify the developed approach and to demonstrate its practicality and effectiveness.
Fields of Sense and Formal Things: The Ontologies of Tristan Garcia and Markus Gabriel
Authors: Kleinherenbrink Arjen 
Published: September 2018

Abstract
A striking feature of the relatively new philosophical genre of speculative realism is that it includes theories that explicitly seek to bridge or overcome the divide between analytic and continental philosophy. Two such theories are Markus Gabriel’s ontology of fields of sense and Tristan Garcia’s ontology of formal things. Both theories hold that all entities - be they physical, mental, fictional, technical, or otherwise - are equally and irreducibly real. This article first describes the core features of these ontologies. This provides insight into these theories themselves and also gives us a glimpse of what philosophy ‘beyond the divide’ might look like. In addition, both theories are shown to be examples of what I will call ‘relational’ philosophy, or philosophy that exhaustively defines entities in terms of how they appear to or feature in other entities. I argue that all such philosophies are haunted by the ‘infinite deferral of specification,’ a specific problem that I argue renders them inconsistent. Finally, I oppose such ‘relationist’ philosophies to ‘substantialist’ ones, and suggest that this distinction might one day succeed the division between analytic and continental philosophy.
Comparison of pendimethalin binding properties of serum albumins from various mammalian species
Authors: Lee Wei Qi , Ahamed Kameel Nurul Iman , Mohamad Saharuddin , Tayyab Saad 
Published: September 2018

Abstract

Background
To investigate the interaction of pendimethalin (PM), a commonly used herbicide, with various mammalian serum albumins.

Methods
The interactions of PM with serum albumins of bovine (BSA), sheep (SSA), porcine (PSA) and rabbit (RbSA) were studied using fluorescence quenching titration and site marker displacement experiments.

Results
A comparison of the PM-induced quenching of the fluorescence of these albumins with that published for human serum albumin (HSA) showed similarity between BSA and HSA. The PM binding affinity of these albumins was found to follow the order: SSA>BSA>RbSA>PSA. Warfarin (WFN) displacement results also suggested similar displacing action of PM on WFN-BSA complex, when compared to the published results on WFN-HSA complex.

Conclusion
The results suggested close similarity between BSA and HSA in terms of PM binding characteristics and hence bovine can be selected as a suitable animal model for further toxicological studies of PM.
Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp.
Authors: de Oliveira Djalma M. , Pereira Cristiane B. , Mendes Graziele , Junker Jochen , Kolloff Markus , Rosa Luiz H. , Rosa Carlos A. , Alves Tânia M.A. , Zani Carlos L. , Johann Susana , Cota Betania B. 
Published: September 2018

Abstract
The endophytic fungus Mycosphaerella sp. (UFMGCB2032) was isolated from the healthy leaves of Eugenia bimarginata, a plant from the Brazilian savanna. Two novel usnic acid derivatives, mycousfuranine (1) and mycousnicdiol (2), were isolated from the ethyl acetate extract, and their structure was elucidated by NMR and MS analyses. Compounds 1 and 2 exhibited moderate antifungal activities against Cryptococcus neoformans and Cryptococcus gattii, each with minimum inhibitory concentration values of 50.0 μg/mL and 250.0 μg/mL, respectively.
Satisfaction among dairy farm owners after certification on good management practices
Authors: Cuartas-Martínez Brayian , Barrios Dursun , Cerón Muñoz Mario Fernando 
Published: September 2018

La adopción de buenas prácticas ganaderas (BPG) en producción de leche implica cambios generadores de satisfacción al personal involucrado en el proceso productivo. Con el objetivo de evidenciar la satisfacción de productores certificados, se encuestaron 37 propietarios de predioslecheros del norte antioqueño, los datos fueron analizados mediante análisis factorial y ecuaciones estructurales. La variable “satisfacción general” se analizó mediante partición recursiva y árboles de regresión. Los productores están satisfechos con la certificación principalmente con los cambios en las condiciones laborales, las interrelaciones y la capacitación del personal. Las BPG satisfacen a los propietarios de sistemas lecheros, al generar cambios en las condiciones laborales del personal, propiciar capacitación permanente y mejorar su imagen ante productores y empresas compradorasde leche.
Genomic Landscape of Adult and Pediatric BCR-ABL1-Like B-Lymphoblastic Leukemia Using Parallel DNA and RNA Sequencing
Authors: Severson Eric A. , Vergilio Jo-Anne , Gay Laurie M. , Daniel Sugganth , Hemmerich Amanda C. , Elvin Julia A. , Britt Nicholas , Nahas Michelle , Cohen Michael B. , Brown Charlotte , Sathyan Pratheesh , Rankin Andrew , Miller Vincent , Ross Jeffrey S. , Ramkissoon Shakti H. 
Published: September 2018

Abstract

BCR-ABL1-like B-Acute Lymphoblastic Leukemia (B-ALL) is a subset of B-ALL with a poor prognosis that is found in all age groups. Definitive identification of these patients is difficult in routine clinical practice as gene expression profiling, the gold standard test, is not widely available. Comprehensive genomic profiling performed on 450 patients with extensive fusion profiling revealed a wide range of genomic alterations which were consistent with a classification of BCR-ABL1-like B-ALL in 29% of cases. This manuscript highlights a clinically available alternative method for identifying a large subset of patients with BCR-ABL1-like B-ALL.
Mülteci Öğrencilerin Eğitim Sorunları, Eğitim ve Din Eğitiminden Beklentileri: Eskişehir Örneği
Authors: TOSUN Aybiçe , YORULMAZ Ayşe , TEKİN İshak , YILDIZ Kübra 
Published: September 2018

Mültecilik olgusu, ülkenin iç, sosyal ve eğitim politikasında
değişikliği gerekli kılar. Bu çalışmada, Eskişehir’e göç eden lise dönemindeki
öğrencilerin buradaki eğitim süreçlerine ilişkin algılarının, yaşadıkları
sorunların, eğitim ve din eğitiminden beklentilerinin tespit edilmesi
amaçlanmıştır. Karma yöntemin benimsendiği bu çalışmada Eskişehir'de devlet
okullarında eğitim alan 83 sığınmacı öğrenci ile bu öğrencilere eğitim veren 42
öğretmenin konuya ilişkin görüşleri, yarı yapılandırılmış görüşme formları ve
anketler aracılığıyla toplanmıştır. Elde edilen veriler kategorik içerik
analizi ile temalandırılmış, ilgili başlıklar altında öğrenci ve öğretmen
görüşleri birlikte sunulmuştur. Çalışmada öğrencilerin dil bilmemelerinin,
sosyal hayatlarında ve okul süreçlerinde en temel uyum problemi olduğu, bunun
farklı sorunlara neden olabildiği tespit edilmiştir. Öğrencilerin din eğitimine
ilişkin algılarının okul türüne göre farklılık gösterdiği görülmüştür
Universal Design. Method of Quality Researches of Residential Space
Authors: KOMAR Beata 
Published: September 2018

Abstract

Problem statement:
The paper fits the trend of Universal Design and focuses on urban space of large housing estates, which is not suitable for all users, and has structural and non-structural barriers.

Methods:
The author for the study of such problems has developed its own method of research, which is part of a larger Urban Audit, published in the author’s habilitation monograph. This article, due to the ability to reach a wider audience, presents this method in English.

Findings and Results:
The method was applied to 4 large housing estates, where a total of 356 seats were examined, and 130 were assessed in a negative way. The managers of surveyed settlements were acquainted with results and modernization proposals, which were soon implemented in their neighborhoods.

Conclusions and recommendations:
The main task developed by the author of the research method is to improve the quality of urban spaces of large housing estates. However, due to its universal character it can also be used for housing built today.
European Agencies’ Headquarters Agreements
Authors: Zieliński Marek 
Published: September 2018

The article examines headquarters agreements concluded by European Agencies (EA) with EU host Member States. This sort of agreement is increasingly visible in practice, as it regulates the status of EAs present within a host state territory. After presenting a list of existing headquarters agreements and describing their content, the article analyses the legal bases for their conclusion. Finally, the legal character of EU agencies’ headquarters agreements, and the position occupied by them within the sources of EU law, are explained. The author considers three possible options regarding the legal nature of the agreements: treaties, administrative agreements and public law contracts. The final conclusion is that EA headquarters agreements are international treaties concluded by EAs in the name of the EU with host Member States.