bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Various Sources of Viral Infection in Strawberry Fields of Quebec, Canada
Authors: Bonneau Phanie , Hogue Richard , Tellier Stéphanie , Fournier Valérie 
Published: July 2019

AbstractThe decline of cultivated strawberry (Fragaria × ananassa Duchesne ex Rozier; Rosaceae) observed in the province of Quebec, Canada, between 2012 and 2014 was mostly caused by persistent viruses: strawberry mild yellow edge virus (SMYEV) (Potexvirus; Alphaflexiviridae) and strawberry crinkle virus (SCV) (Cytorhabdovirus; Rhabdoviridae); and semi-persistent viruses: strawberry mottle virus (SmoV) (Secoviridae), strawberry vein banding virus (SVBV) (Caulimovirus; Caulimoviridae), and strawberry pallidosis virus (SPaV) (Crinivirus: Closteroviridae) transmitted by insect vectors. The objective of this study was to determine the sources of viral contamination in commercial strawberry fields in Quebec. Specifically, we wished to 1) determine the prevalence of persistent viruses in winged strawberry aphid Chaetosiphon fragaefolii (Cockerell) (Hemiptera: Aphididae) specimens captured; 2) determine the prevalence of all viruses in wild strawberry Fragaria virginiana Miller plants near commercial plantings; and 3) evaluate the viral contamination of strawberry transplants obtained from nurseries and tested before and after planting in commercial strawberry fields. Results indicated high percentage (38%) of the aphids (n = 205) and high percentage (67%) of F. virginiana patches (n = 12) were infected by strawberry viruses. Ultimately, our results showed a low percentage (5%) of the plants from various nurseries (n = 56) were infected before planting, whereas a third (29%) of the healthy exposed plants in the fields (n = 96) became rapidly infected by insect vectors within a year of having been planted. This study provides significant insights on the relative importance of the various sources of contamination in Quebec strawberry fields: C. fragaefolii versus F. virginiana versus nurseries versus post-nursery infections through exposure to virus-carrying insects.
The Balance Intensity Scales for Therapists and Exercisers Measure Balance Exercise Intensity in Older Adults: Initial Validation Using Rasch Analysis
Authors: Farlie Melanie K , Keating Jennifer L , Molloy Elizabeth , Bowles Kelly-Ann , Neave Becky , Yamin Jessica , Weightman Jussyan , Saber Kelly , Haines Terry P 
Published: July 2019

AbstractBackgroundThe Balance Intensity Scales (BIS) have been developed to measure the intensity of balance exercise in older adults.ObjectiveThe objective was to determine whether the BIS for therapists (BIS-T) and for exercisers (BIS-E) are unidimensional measures of balance exercise intensity, able to be refined using the Rasch model into a hierarchical item order, and appropriately targeted for the older adult population with a variety of diagnoses in a range of exercise testing settings.DesignThis was a scale development study using a pragmatic mixed-methods approach.MethodsOlder adult exercisers (n = 108) and their therapists (n = 33) were recruited from a large metropolitan health service and rated balance exercise tasks on the BIS-T and BIS-E in a single session.ResultsScores on both the BIS items and global effort ratings for therapists and exercisers had good correlation and demonstrated unidimensionality. The BIS-T and BIS-E demonstrated a hierarchical distribution of items that fit the Rasch model. The Person Separation Index was moderate (0.62) for the BIS-T but poor (0.33) for the BIS-E.LimitationsThe limitations were that therapists in this study underprescribed high-intensity balance tasks.ConclusionsInitial validation of the BIS-T and the BIS-E demonstrated that these scales can be used for the measurement of balance exercise intensity in older adult populations. The BIS-T items and global effort ratings are recommended for use by therapists, and the global effort ratings are recommended for use by exercisers. Ongoing validation of both scales using high-intensity balance task ratings and different populations of older adults is recommended.
An assessment of engaged social science research in nanoscale science and engineering communities
Authors: Radatz Alecia , Reinsborough Michael , Fisher Erik , Corley Elizabeth , Guston David 
Published: July 2019

AbstractIncreased funding of nanotechnology research in the USA at the turn of the millennium was paired with a legislative commitment to and a novel societal research policy for the responsible development of nanotechnology. Innovative policy discourses at the time suggested that such work could engage a variety of publics, stakeholders, and researchers to enhance the capacity of research systems to adapt and be responsive to societal values and concerns. This article reviews one of two federally funded social science research centers—the Center for Nanotechnology in Society at Arizona State University(CNS-ASU)—to assess the merits of this form of engaged social science research in which social science contributes not only to traditional knowledge production but also to the capacity of natural science and engineering researchers and research communities for greater reflexivity and responsiveness, ultimately producing more socially robust research systems.
ASSESSMENT OF CENTRAL SEROUS CHORIORETINOPATHY DEPICTED ON COLOR FUNDUS PHOTOGRAPHS USING DEEP LEARNING
Authors: Zhen Yi , Chen Hang , Zhang Xu , Meng Xin , Zhang Jian , Pu Jiantao 
Published: July 2019

Purpose:
To investigate whether and to what extent central serous chorioretinopathy (CSC) depicted on color fundus photographs can be assessed using deep learning technology.

Methods:
We collected a total of 2,504 fundus images acquired on different subjects. We verified the CSC status of these images using their corresponding optical coherence tomography images. A total of 1,329 images depicted CSC. These images were preprocessed and normalized. This resulting data set was randomly split into three parts in the ratio of 8:1:1, respectively, for training, validation, and testing purposes. We used the deep learning architecture termed Inception-V3 to train the classifier. We performed nonparametric receiver operating characteristic analyses to assess the capability of the developed algorithm to identify CSC. To study the inter-reader variability and compare the performance of the computerized scheme and human experts, we asked two ophthalmologists (i.e., Rater #1 and #2) to independently review the same testing data set in a blind manner. We assessed the performance difference between the computer algorithms and the two experts using the receiver operating characteristic curves and computed their pair-wise agreements using Cohen's Kappa coefficients.

Results:
The areas under the receiver operating characteristic curve for the computer, Rater #1, and Rater #2 were 0.934 (95% confidence interval = 0.905–0.963), 0.859 (95% confidence interval = 0.809–0.908), and 0.725 (95% confidence interval = 0.662–0.788). The Kappa coefficient between the two raters was 0.48 (P < 0.001), while the Kappa coefficients between the computer and the two raters were 0.59 (P < 0.001) and 0.33 (P < 0.05).

Conclusion:
Our experiments showed that the computer algorithm based on deep learning can assess CSC depicted on color fundus photographs in a relatively reliable and consistent way.
Regulatory and Developmental Aspects of Biomarkers in the Treatment of Ocular Surface Disease
Authors: Novack Gary D. 
Published: July 2019

Abstract:
The ideal biomarker would be a simple laboratory or clinical evaluation before treatment, which would predict subsequent therapeutic response. This might include selection of which patients might respond to that treatment. While other disciplines such as neurology and oncology have biomarkers, ophthalmology is limited to one—elevated intraocular pressure as a surrogate for progressive glaucomatous field loss. US law in 2016 required the Food and Drug Administration (FDA) to set up a system to qualify biomarkers. The system now exists—with most validated or pending biomarkers limited to safety and infection. The American Academy of Ophthalmology selected dry eye disease as one of three diseases in which to standardize outcomes in ophthalmology research. There have been a number of biomarkers proposed for evaluating ocular surface disease and its treatment. None currently meets the scientific or regulatory basis for being a valid biomarker—however, additional research may result in validity. Given the FDA's scientific basis, it is unlikely that an unproven biomarker could be used for regulatory approval, even for a “SubPart H” conditional new drug application. Elsewhere in ophthalmology, we know that even patients who share the same disease gene or mutation may differ substantially in penetrance and clinical expression. Thus, it is not unexpected that ocular surface disease, a heterogeneous disease with a variable presentation of signs and symptoms, has yet to have validated biomarkers that reach the level of evidence that allows their use for diagnosis, prognosis, therapy, and for making decisions in drug development.
Adenocarcinoma of the Stomach Leading to Recurrent Regurgitation and Muscular Hypermetabolism on 18F-FDG PET/CT
Authors: Parihar Ashwin Singh , Vadi Shelvin Kumar , Kumar Rajender , Mittal Bhagwant Rai , Singh Harmandeep , Kapoor Rakesh 
Published: July 2019

Abstract
Skeletal muscle uptake of 18F-FDG can result from a variety of physiologic and pathologic conditions. It is important for the physician to interpret these uptake patterns in the correct context to avoid a misdiagnosis. We present a case of a 36-year-old man with progressive, repeated episodes of regurgitation who was diagnosed with adenocarcinoma of the stomach. 18F-FDG PET/CT showed increased tracer uptake in the primary tumor and in the intercostal and sternocleidomastoid muscles. The pattern of tracer uptake along with the clinical history and examination of the patient helped differentiate a physiologic variant from a pathologic cause.
Celiac Disease on FDG PET/CT
Authors: Cardin Anthony Joshua , Patel Mihir , Ma Dickson 
Published: July 2019

Abstract
An FDG PET with diagnostic CT was performed on a 52-year-old man for investigation of lymphocytosis and the clinical suspicion of lymphoma. The PET/CT demonstrated diffuse small bowel uptake, prominent mesenteric lymph nodes without significant FDG uptake, and other features suggestive of celiac disease. Subsequently, the patient was found to have markedly elevated celiac disease antibodies (deamidated gliadin IgG and tissue transglutaminase IgA) and to be HLA DQ2 and DQ8 allele positive on genotyping for celiac disease. Gastroscopy and duodenal biopsy also confirmed the diagnosed.
Cervical Stenosis in Non-Syndromic Pierre Robin Sequence
Authors: Abu-Ghname Amjed , Masoumy Mohamad , Monson Laura A. 
Published: July 2019

Abstract
Pierre Robin sequence is a triad of micrognathia, glossoptosis, and airway obstruction that has reported associations with numerous birth defects and anomalies including craniocervical pathologies. Given the number of airway assessments and neck manipulations these neonates experience, undetected cervical instability can result in detrimental consequences. The authors present a case of a neonate with non-syndromic Pierre Robin sequence planned for mandibular distraction osteogenesis that developed abnormal motor activity following intubation. The patient was eventually diagnosed with cervical spine stenosis and craniocervical instability after radiologic investigation. This paper demonstrates the significance of preoperative cervical spine evaluation and the importance of maintaining high level of suspicion when performing neck manipulations in those high-risk infants.
Beneficial Effects of Ivabradine on Post-Resuscitation Myocardial Dysfunction in a Porcine Model of Cardiac Arrest
Authors: Yang Min , Chen Limin , Hua Tianfeng , Zou Yangyang , Yang Zhengfei 
Published: July 2019

ABSTRACT

Background:
Ivabradine selectively inhibits the If current, reducing the heart rate and protecting against myocardial ischemia/reperfusion injury. We investigated the effects of ivabradine on post-resuscitation myocardial function in a porcine model of cardiopulmonary resuscitation.

Methods and Results:
Ventricular fibrillation was induced and untreated for 8 min while defibrillation was attempted after 6 min of cardiopulmonary resuscitation in anesthetized domestic swine. Then the animals were randomized into ivabradine and placebo groups (n = 5 each). Ivabradine and saline were administered at the same volume 5 min after Return of Spontaneous Circulation, followed by continuous intravenous infusion at 0.5 mg/kg for 480 min. Hemodynamic parameters were continuously recorded. Myocardial function was assessed by echocardiography at baseline and at 60, 120, 240, 480 min and 24 h after resuscitation. The serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) were measured by commercial enzyme-linked immunosorbent assay kits. Animals were killed 24 h after resuscitation, and all myocardial tissue was removed for histopathological analysis. The heart rate was significantly reduced from 1 h after resuscitation in the ivabradine group (all P < 0.05). The post-resuscitation mitral E/A and E/e′ velocity ratios and left ventricular ejection fraction were significantly better in the ivabradine than placebo group (P < 0.05). The serum levels of myocardial injury biomarkers (NT-proBNP, cTnI) and the myocardial biopsy scores were significantly lower in the ivabradine than placebo group (P < 0.05). Neurological deficit scores were lower in the IVA group at PR 24 h (P < 0.05).

Conclusions:
Ivabradine improved post-resuscitation myocardial dysfunction, myocardial injury, and post-resuscitation cerebral function, and also slowed the heart rate in this porcine model.
Heavy chain-1 of inter-α-inhibitor has an integrin-like structure with immune regulatory activities
Authors: Briggs David C. , Langford-Smith Alexander W.W. , Jowitt Thomas A. , Kielty Cay M. , Enghild Jan J. , Baldock Clair , Milner Caroline M. , Day Anthony J. 
Published: July 2019

AbstractInter-α-inhibitor (IαI) is a proteoglycan essential for mammalian reproduction that also plays a less well-characterised role in inflammation. IαI is composed of 2 homologous ‘heavy chains’ (HC1 and HC2) covalently attached to chondroitin sulphate on the bikunin core protein. Prior to ovulation HCs are transferred onto the polysaccharide hyaluronan (HA), thereby stabilising a matrix that is required for fertilisation. Here we show that human HC1 has a structure similar to integrin β-chains and contains a functional MIDAS (metal ion-dependent adhesion site) motif that can mediate self-association of heavy chains, providing a mechanism for matrix crosslinking. Surprisingly, its interaction with RGD-containing integrin ligands, such as vitronectin and the latency-associated peptides of TGFβ, occurs in a MIDAS/cation-independent manner. However, HC1 utilises its MIDAS motif to bind to, and inhibit the cleavage of, complement C3, thus identifying it as a novel regulator of innate immunity through inhibition of the alternative pathway C3 convertase.AbbreviationsADPs, atomic displacement parameter; AUC, analytical ultracentrifugation; CMG2, capillary morphogenesis protein-2; COC, cumulus-oocyte complex; CS, chondroitin sulphate; FB, complement factor B; FnIII; fibronectin type III; HA, hyaluronan; HC, heavy chain; HC•HA, covalent complex of HC with HA; IαI, inter-α-inhibitor; ITGA, integrin α-chain; ITGB, integrin β-chain; LAP, latency associated peptide; LLC, large latent complex; LTBP, latent TGFβ binding protein; MIDAS, metal ion-dependent adhesion site; PαI, pre-α-inhibitor; PTX3, pentraxin-3; rHC1, recombinant HC1; SAXS, small-angle X-ray scattering; SHAP, serum-derived HA binding protein; SLC, small latent complex; TEM8, tumour endothelial marker-8; TGFβ, transforming factor β; TSG-6, tumour necrosis factor-stimulated gene-6; TSG-6•HC, covalent complex of TSG-6 and HC; vWFA domain, von Willebrand Factor A domain.
Size effect on thermal elastohydrodynamic lubrication of industrial chain bush-pin hinge pair
Authors: Zhang Mingyu , Wang Jing , Liu Yi , Dai Longjie , Shang Zhaohua 
Published: July 2019

Purpose
The purpose of this paper is to use elastohydrodynamic lubrication (EHL) theory to study the variation of the equivalent curvature radius “R” on the change of oil film thickness, pressure, temperature rise and friction coefficient in the contact zone between bush-pin in industrial chain drive.

Design/methodology/approach
In this paper, the contact between bush and pin is simplified as infinitely long line contact. The lubrication state is studied by numerical simulation using steady-state line contact thermal EHL. The two constitutive equations, namely, Newton fluid and Ree–Eyring fluid are used in the calculations.

Findings
It is found that with the increase of equivalent curvature radius, the thickness of oil film decreases and the temperature rise increases. Under the same condition, the friction coefficient of Newton fluid is higher than that of Ree–Eyring fluid. When the load increases, the oil film thickness decreases, the temperature rise increases and the friction coefficient decreases; and the film thickness increases with the increase of the entraining speed under the condition “R < 1,000 mm”.

Research limitations/implications
The infinite line contact assumption is only an approximation. For example, the distances between the two inner plates are 5.72 mm, by considering the two parts assembled into the inner plates, the total length of the bush is less than 6 mm. The diameter of the pin and the bore diameter of the bush are 3.28 and 3.33 mm. However, the infinite line contact is also helpful in understanding the general variation of oil film characteristics and provides a reference for the future study of finite line contact of chain problems.

Originality/value
The change of the equivalent radius R on the variation of the oil film in the contact of the bush and the pin in industrial chain drive was investigated. The size effect influences the lubrication characteristic greatly in the bush-pin pair.
Effects of macrolides on airway microbiome and cytokine of children with bronchiolitis: A systematic review and meta‐analysis of randomized controlled trials
Authors: Zhang Yin , Dai Jihong , Jian Hui , Lin Jilei 
Published: July 2019

AbstractMacrolides may attenuate airway inflammation of bronchiolitis with anti‐inflammatory and antiviral effects. However, the potential mechanisms of action underlying the efficiency of macrolides in treating bronchiolitis are limited. Therefore, we performed a meta‐analysis to assess the effects of macrolides on airway microbiome and cytokine of children with bronchiolitis. PubMed, Embase, and Cochrane Central Register of Controlled Trials were searched until May 2018. The reference lists of included studies and pertinent reviews were investigated for supplementing our search. Randomized controlled trials (RCTs) that compared macrolides with placebo assessing the change of microbiome in airway and cytokine were included. A total of four RCTs were included in this review. Data analysis showed no significant reduction of viruses at 48 hr after azithromycin treatment (p = 0.41). There were significant reductions in Streptococcus pneumoniae (risk ratio [RR] 0.28, 95% confidence interval (CI) 0.14 to 0.6, p < 0.01), Haemophilus influenza (RR 0.35, 95% CI 0.2 to 0.62, p < 0.01), and Moraxella catarrhalis (RR 0.29, 95% CI 0.17 to 0.5, p < 0.01), but no significant reduction of Staphylococcus aureus (p = 0.28) following treatment with macrolides. There was a significant decrease in the serum interleukin‐8(IL‐8), interleukin‐4(IL‐4), and eotaxin levels following 3 weeks of clarithromycin therapy. There was no significant difference in the serum IL‐8 level at Day 15 after the intervention between the azithromycin and control groups; however, a significant reduction of nasal lavage IL‐8 level was found. The macrolides may reduce the IL‐8 levels in the airway and plasma, but failed to demonstrate an antiviral effect in children with bronchiolitis.
Consistent temperature dependence of functional response parameters and their use in predicting population abundance
Authors: Archer Louise C. , Sohlström Esra H. , Gallo Bruno , Jochum Malte , Woodward Guy , Kordas Rebecca L. , Rall Björn C. , O’Gorman Eoin J. 
Published: July 2019

Abstract

Global warming is one of the greatest threats to the persistence of populations: increased metabolic demands should strengthen pairwise species interactions, which could destabilize food webs at the higher organizational levels. Quantifying the temperature dependence of consumer–resource interactions is thus essential for predicting ecological responses to warming.
We explored feeding interactions between different predator–prey pairs in controlled‐temperature chambers and in a system of naturally heated streams. We found consistent temperature dependence of attack rates across experimental settings, though the magnitude and activation energy of attack rate were specific to each predator, which varied in mobility and foraging mode.
We used these parameters along with metabolic rate measurements to estimate energetic efficiency and population abundance with warming. Energetic efficiency accurately estimated field abundance of a mobile predator that struggled to meet its metabolic demands, but was a poor predictor for a sedentary predator that operated well below its energetic limits. Temperature effects on population abundance may thus be strongly dependent on whether organisms are regulated by their own energy intake or interspecific interactions.
Given the widespread use of functional response parameters in ecological modelling, reconciling outcomes from laboratory and field studies increases the confidence and precision with which we can predict warming impacts on natural systems.
Species diversity and dispersal traits alter biodiversity spillover in reconstructed grasslands
Authors: Sperry Katie P. , Hilfer Hayley , Lane Ian , Petersen Jessica , Dixon Philip M. , Sullivan Lauren L. 
Published: July 2019

Abstract

Grasslands are among the planet’s most imperilled ecosystems, largely because habitat conversion has caused extreme biodiversity loss. In response, managers and scientists aim to recreate grassland habitat, yet these reconstructed grasslands are often species‐poor and lose diversity through time. One potential mechanism to promote biodiversity in grasslands is spillover, or the targeted dispersal of species across habitat boundaries from areas of high to low biodiversity. There is potential for native species to disperse via spillover from high‐quality remnant habitat and establish in reconstructions, thus increasing biodiversity. However, plant dispersal and establishment are often context dependent, and the conditions that promote spillover in grasslands are largely unknown.

Here we examine the contexts under which spillover can enhance biodiversity in grasslands. Specifically, we investigate whether the species richness of reconstructions and individual plant dispersal traits alter spillover. To do so, we surveyed plant species richness at reconstructed grasslands of varying diversity adjacent to remnant grasslands.

We found that spillover from remnants supplies reconstructions with rare species that would otherwise not be present, but only in reconstructions with lower overall richness. Furthermore, spillover was more likely to occur for species with wind dispersed seeds than species with unassisted seed dispersal.

Synthesis and applications. Our results show that the context dependency of both dispersal and establishment processes are critical to understanding when and where spillover can promote biodiversity in reconstructed systems. Understanding these contexts will help land managers leverage natural dispersal to mitigate biodiversity loss by anticipating which species are likely to arrive in reconstructions without assistance and when they are likely to establish.