bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF CRITICAL THINKING IN CLASS 4 STUDENTS OF SDN 2 KUTOSARI IN THEMATIC LEARNING 2013 CURRICULUM
Authors: Saputri Marchelina Dwi , Suryandari Kartika Chrysti 
Published: October 2019

<em>Thematic learning in 2013 curriculum has competence time front that is ability thinking clear and critical</em><em>. Student could said have ability critical thinking if they pass by 6 step</em><em>s of Critical thinking. So this study was a purpose was to analyze critical thinking in class 4 students of SD N 2 Kutosari in thematic learning 2013 curriculum. This study used descriptive qualitative method. The research subjects were the fourth grade studenst of SD N 2 Kutosari. Data collection though observation, documentation and interview to the fourth grade student. Result research show ability critical thinking of class 4 student of SDN 2 Kutosari already exists, but students do not always think critically but only in limited learning. conducted students begin to be critical with 47,72% of students able to think critically. So the teacher lures students to think critically based on six step of critical thinking</em>
Identification and Preliminary Toxicological Assessment of a Non-Regulated Mineral Fiber: Fibrous Antigorite from New Caledonia
Authors: Petriglieri Jasmine Rita , Laporte-Magoni Christine , Salvioli-Mariani Emma , Tomatis Maura , Gazzano Elena , Turci Francesco , Cavallo Alessandro , Fubini Bice 
Published: October 2019

ABSTRACT
The rising awareness about the risk due to asbestos environmental exposure has led to a new interest in the investigation of non-regulated mineral fibers. Evidence of chronic diseases has been described in individuals exposed to naturally occurring asbestiform (NOA) minerals in Turkey (erionite), Italy (fluoro-edenite), and the United States (winchite/richterite). In New Caledonia, an increased incidence of asbestos-related diseases was correlated with the natural occurrence of fibrous serpentines chrysotile and fibro-lamellar antigorite in outcrops, roadways, and soils. A minor amount of tremolite asbestos was also observed, increasing the health hazard. By adopting a precautionary principle, New Caledonia legislation classified antigorite as regulated asbestos, even if limited toxicity assessment is available. Caledonian antigorite exhibits a wide range of natural shapes, morphologies, and degrees of alteration as a result of pedogenic alteration induced by subtropical conditions. As the alteration increases, lamellar antigorite gradually cleaves into fibrous-like particles, assuming a fibro-lamellar habit. An increase in the emission of inhalable (potentially asbestiform) fibers in air was observed. To understand this mechanism, a multidisciplinary mineralogical and geochemical investigation was carried out. Additionally, several in vitro tests have been performed on three antigorite samples, subjected to different levels of alteration, to collect preliminary information on antigorite toxicity. Alteration modifies the surface reactivity of antigorite. The circulation of fluids induces a mechanical stress and an elemental exchange at mineral/water interface, promoting the loss of cohesion of the mineral structure and affecting the surface chemistry and toxicity of fibrous (asbestiform) antigorite.
Nasopharyngeal carriage, spa types and drug susceptibility profiles of Staphylococcus aureus from healthy children under 5 years in eastern Uganda
Authors: Kateete David , Asiimwe Benon B , Mayanja Raymond , Mujuni Brian , Bwanga Freddie , Najjuka Christine F , Källander Karin , Rutebemberwa Elizeus 
Published: October 2019

Abstract
Background:
Staphylococcus aureus carriage is a known risk factor for staphylococcal disease. However, the carriage rates vary by country, demographic group and profession. This study aimed to determine the S. aureus carriage rate in children in Eastern Uganda, and track Staphylococcus strains that can cause infection in Uganda.
Methods:
Nasopharyngeal samples from 742 healthy children under 5 years residing in the Iganga/Mayuge Health & Demographic Surveillance Site in Eastern Uganda were processed for isolation of S. aureus. Antibiotic resistance based on minimum inhibitory concentrations (MICs) was determined by the BD Phoenix™ automated identification & susceptibility testing system. Genotyping was performed by spa typing.
Results:
The processed samples yielded 144 S. aureus isolates (one per child) therefore, the S. aureus carriage rate in children was 19.4% (144/742). Thirty one percent (45/144) of the isolates were methicillin resistant (MRSA) yielding a carriage rate of 6.1% (45/742). All MRSA isolates were susceptible to vancomycin, linezolid and clindamycin however, compared to methicillin susceptible S. aureus (MSSA) (68.8%, 99/144), MRSA isolates were more resistant to non-beta-lactam antimicrobials –tetracycline (91.1%, 41/45), trimethoprim/sulfamethoxazole (73.3%, 33/45), erythromycin (75.6%, 34/45), chloramphenicol (60%, 27/45), gentamicin (55.6%, 25/45) and ciprofloxacin (35.6%, 16/45). Furthermore, one MRSA isolate was mupirocin resistant and 42 (93.3%, 42/45) were multidrug resistant (MDR); three (3%, 3/99) MSSA isolates were mupirocin and clindamycin resistant, while 61 (61.6%, 61/99) were MDR. All MSSA/MRSA isolates were susceptible to rifampicin, vancomycin and linezolid but only three MSSA were pan-susceptible to antibiotics. Seven spa types were detected in MRSA, of which t037 & t064 were predominant and associated with SCCmec types I & IV, respectively. Fourteen spa types were detected in MSSA, of which t645 & t4353 were predominant.
Conclusions:
S. aureus (MSSA/MRSA) carriage rate in children in Eastern Uganda is high and comparable to rates for hospitalized patients in Kampala city. The detection of mupirocin resistance is worrying as it could rapidly increase if mupirocin is administered in a low-income setting. S. aureus strains of spa types t064, t037 (MRSA) and t645, t4353 (MSSA) are prevalent and could be responsible for majority of staphylococcal infections in Uganda.
Association between family history and essential hypertension in Han population in Shanghai China
Authors: anle li , Peng Qian , Shao Yue Qin , Zhang Yi Ying , Xiang Fang 
Published: October 2019

Abstract
Backgrounds

Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors.Objective

To explore the association between family history and essential hypertension in Han population in Shanghai China.Methods

The method of case-control study was used,342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the both study groups. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history.Results

The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives was significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42, 49.16, 39.55, 39.88, 43.67 or 43.64 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90, 51.17, 51.07, 51.08, 50.50 or 50.57 years old. The difference about two groups showed statistically significant.Conclusion

Family history had a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects were different among parent and grandparent in Han in Shanghai China.
The phylogenetic significance of the morphology of the syrinx, hyoid and larynx, of the Southern Cassowary, Casuarius casuarius (Aves, Palaeognathae)
Authors: McInerney Phoebe Louise , Lee Michael S. Y. , Clement Alice M. , Worthy Trevor H. 
Published: October 2019

Abstract
The Palaeognathae are a basal clade within Aves and include the large and flightless ratites and the smaller, volant tinamous. Although much research has been conducted on various aspects of palaeognath morphology, ecology, and evolutionary history, there are still areas which require investigation. This study aimed to fill gaps in our knowledge of the Southern cassowary, Casuarius casuarius , for which information on the skeletal systems of the syrinx, hyoid and larynx is lacking despite these structures having been recognised as performing key functional roles associated with vocalisation, respiration and feeding. Previous research into the syrinx and hyoid have also indicated these structures to be valuable for determining evolutionary relationships among neognath taxa, and thus be informative for palaeognath phylogenetic analyses, which still exhibits strong conflict between morphological and molecular trees. We documented variation across palaeognaths in the skeletal character states of the syrinx, hyoid, and larynx, using both the literature and novel observations (e.g. of cassowary). Notably the molecular moa-tinamou clade was found to share morphological character traits including the ossification of the cricoid and arytenoid cartilages, and an additional cranial character, the articulation between the maxillary process of the nasal and the maxilla. These findings contributed to optimisation of syrinx, hyoid and larynx characters showing increased phylogenetic support for palaeognath relationships derived from a molecular and morphological combined-data topology.
Cost of incorrect application of antithrombotic prophylaxis prior to invasive procedures
Authors: Cuevas María Victoria , Martínez-Sancho Ignacio , Arribas Jana , García-Díaz Covadonga , Cuevas Beatriz 
Published: October 2019

Abstract
Background

We analyze the cost of an incorrect application, by the haematologist, of bridging anticoagulation in patients with low-risk atrial fibrillation (AF) needing interruption of treatment prior to a scheduled invasive procedure. Although not recommended, bridging therapy is widely used, resulting in avoidable costs and increased workload.

Methods

Observational retrospective study. We recorded demographic and clinical data including age, sex, type of procedure, use of bridging therapy with low molecular weight heparin (LMWH), and haemorrhagic complications within 30 days of acenocoumarol withdrawal.

Results

Acenocoumarol was stopped in 161 patients, 97 (60%) were male and 64 (40%) female. Average age was 76,11 ± 8,45 years. Procedures included: minor surgical intervention 58 (36%), colonoscopy 61 (38%), gastroscopy 11 (7%), breast biopsy 4 (2.5%), prostate biopsy 4 (2.5%), infiltration 5 (3%), and other 18 (11%). All patients received bridging anticoagulation with LMWH (40mg enoxaparin per day) 3 days before and 3 days after the procedure (6 doses). We used a total of 966 doses, at €4.5 per unit, resulted in €4,347 of total cost. No complications occurred in 156 patients (97%). Haemorrhage was observed in 5 cases: 1 major haemorrhage needing 6 days of hospital stay and transfusion, and 4 minor haemorrhages (2 patients needed emergency attendance and 2 required hospital admission for 3 and 2 days, respectively). The cost of emergency care was €237.36, and the cost of hospital stay was €6860.81 (€623.71 per day, for 11 days). The total cost of the incorrect application of the protocol was €11445.17.

Conclusion

Guidelines about bridging anticoagulation in low risk AF patients undergoing scheduled invasive procedures were not followed. This practice increments the complications and supposes an increase in costs besides to an inadequate use of the human resources.
Validation of the Clinical Frailty Score (CFS) in French language
Authors: ABRAHAM PAUL , COURVOISIER Delphine S. , ANNWEILER Cedric , LENOIR Cliff , MILLIEN Thomas , DALMAZ Francoise , FLATTEN Hans , MORENO Rui , CHRISTENSEN Steffen , GUIDET Bertrand , Bendjelid Karim , WALDER Bernhard , PINTO Bernardo BOLLEN 
Published: October 2019

Abstract
Background
Very old critical ill patients are a rapid expanding group in the ICU. To better understand the magnitude of the challenges involved in intensive care practice for an ageing population and discuss a rational allocation of resources (admission, triage and level of care) for such patients, healthcare practitioners need a reliable evaluation of frailty.
In order to promote the adequate use of the clinical frailty Scale (CFS) in a wider panel of countries, we aimed to develop, validate and characterise a French (FR) version from the originale English (EN) CFS.
Results
Inter-rater reliability was 0.87 (95%CI: 0.76-0.93) between doctors for the original CFS version and 0.76 (95%CI: 0.57-0.87) between nurses for the FR version. Inter-rater variability between doctor and nurse was 0.75 (95%CI: 0.56-0.87) for the original version, and 0.73 (95%CI: 0.52-0.85) for the FR version.
Test-retest (stability) with the original vs the FR version was 0.86 (95%CI: 0.72-0.93) for doctors and 0.87 (95%CI: 0.76-0.93) for nurses.
Differences between the evaluations of the CFS-EN and CSF-FR were not different from 0, with a mean difference of 0.06 (95%CI -0.24, 0.36) for the EN version and -0.03 (95%CI -0.47, 0.41) for the FR version. Agreement between the FR and the EN version for doctors was similar. Average original version ratings were slightly lower than FR version ratings, though this difference did not reach significance: -0.29 (95%CI -0.54, 0.04).
There were no significant differences in the CFS scores between participants who died within 30 days and participants who survived for either the original (median survived: 4.7, median died: 4.0, p=0.52) or FR (median survived: 4.7, median died: 4.5, p=0.56) versions
Conclusion
In this prospective cohort of very old intensive care participants we developed and tested the basic psychometric properties (internal consistency, reproducibility) of a French version of the CFS. This manuscript provides clinically meaningful psychometric properties that have not been previously reported in any other language, including in the original EN version.
The French cultural adaptation of this CFS has adequate psychometric properties for doctors or nurses to evaluate frailty in very old intensive care patients.
Absorbable suture can be effectively and safely used to close the mesenteric defect in a Gastric bypass Sprague-Dawley Rat Model
Authors: Yao Libin , Dolo Ponnie Robertlee , Shao Yong , Li Chao , Widjaja Jason , Hong Jian , Zhu Xiaocheng 
Published: October 2019

Abstract
Background: To observe if closing the mesenteric defect with absorbable sutures creates a safe adhesion compared to non-absorbable suture after Roux-en-Y gastric bypass.Methods: Rats were randomly assigned to 5 experimental groups according to the different suture materials used in closing the mesenteric defects (Peterson’s space) after Roux-en-Y gastric bypass. Group A (control group), Group B (non-absorbable suture, Prolene suture), Group C (biological glue), Group D (non-absorbable suture, polyester suture) and Group E (absorbable suture). All rats were followed up for 8 weeks postoperatively and underwent laparotomy to observe the degree of adhesion and closure of the mesenteric defect.Results: No significant difference was found in the decrease in food intake and body weight among all groups. No internal hernia (IH) occurred in any group. The mesenteric defects of Group A remained completely visible without any closure or adhesion. Multiple gaps were found between the Prolene suture and the mesentery along the suture line in Group B. The mesenteric defects of Group C were complete closed with multiple adhesions of the small intestine and the greater omentum. The mesenteric defects in both Group D and Group E closed completely. The average adhesion scores in Group A and Group B were 0 and 0.33±0.52 respectively. The average adhesion score in group C (3.83±0.41) was higher than the other groups (p＜0.05). The average adhesion scores in Group D and E were similar (3.17±0.41 and 3.00±0.00 respectively).
Conclusion: Absorbable suture created a safe adhesion score between the mesentery which was not inferior to non-absorbable sutures.
Prolotherapy injections and physiotherapy used singly and in combination for lateral epicondylalgia: A single-blinded randomised clinical trial.
Authors: Yelland Michael , Rabago David , Ryan Michael , Ng Shu-Kay , Vithanachchi Dinusha , Manickaraj Nagarajan , Bisset Leanne 
Published: October 2019

Abstract
Background Lateral epicondylalgia (tennis elbow) is a common, debilitating and often treatment-resistant condition. Two treatments thought to address the pathology of lateral epicondylalgia are hypertonic glucose plus lignocaine injections (prolotherapy) and a physiotherapist guided manual therapy/exercise program (physiotherapy). This trial aimed to compare the short- and long-term clinical effectiveness, cost effectiveness, and safety of prolotherapy used singly and in combination with physiotherapy. Methods Using a single-blinded randomised clinical trial design, 120 participants with lateral epicondylalgia of at least six weeks’ duration were randomly assigned to prolotherapy (4 sessions, monthly intervals), physiotherapy (weekly for 4 sessions) or combined (prolotherapy+physiotherapy). The Patient-Rated Tennis Elbow Evaluation (PRTEE) and participant global impression of change scores were assessed by blinded evaluators at baseline, 6, 12, 26 and 52 weeks. Success rate was defined as the percentage of participants indicating elbow condition was either 'much improved' or 'completely recovered.’ Analysis was by intention-to-treat. Results 88% completed the 12-month assessment. At 52 weeks, there were substantial, significant improvements compared with baseline status for all outcomes and groups, but no significant differences between groups. The physiotherapy group exhibited greater reductions in PRTEE at 12 weeks than the prolotherapy group (p = 0.014).Conclusion There were no significant differences amongst the Physiotherapy, Prolotherapy and Combined groups in PRTEE and global impression of change measures over the course of the 12-month trial.
Single-center Experience in the Treatment of Extremely Medial Clavicle Fractures with Vertical Fixation of Double-plate
Authors: Liu He , Zhang Ziyan , Yuan Baoming , Ren Guangkai , Yu Junlong , Peng Chuangang , Wu Dankai 
Published: October 2019

Abstract
Background: Patients suffering from medial clavicle fractures combined with displacement need surgical intervention. This research reports the effect of double-plate fixation as an innovative procedure in the treatment of extremely medial clavicle fractures.Methods: Nine patients complaint of extremely medial clavicle fracture were enrolled in this research from Mar 2017 to March 2018. Patients were treated with an open reduction and internal fixation using the double-plate technique. Postoperative X-ray was taken regularly to observe the fracture healing at each visit, and the related complications were also recorded. The rating score systems of Constant Murley score of treated shoulder and contralateral shoulder, Rowe score as well as American Shoulder and Elbow Surgeons (ASES) were questionnaire to evaluate postoperative shoulder joint function.Results: All patients achieved postoperative fracture healing with no complications. Only one patient complained of slight restriction, two patients complained of pain during overhead work, and another patient occurred plate breakage. Meanwhile, the Constant Murley scores of treated and contralateral shoulder were 94.1 and 98.5 points, respectively, indicating the similar shoulder function. Furthermore, the Rowe and ASES scores of the involved shoulder were 96.7 and 96.3 points at average, respectively.Conclusions: It is the first time to introduce the surgical technique of vertical double-plate fixation for stable fixation of extremely medial clavicle fractures, which could provide the surgeons an alternative method for this type of fracture.
Catastrophic Healthcare Expenditure and Coping Strategies among Patients Attending Cancer Treatment Services in Addis Ababa, Ethiopia
Authors: Kasahun Gebremicheal Gebreslassie , Gebretekle Gebremedhin Beedemariam , Gecho Yohannes Hailemichael , Woldemariam Aynalem Abraha , Fenta Teferi Gedif 
Published: October 2019

Abstract
Background: With the rapid increase in magnitude and mortality of cancer, which is costly disease to manage, several patients particularly in developing countries are facing a huge financial burden. Objective: The purpose of the study was to examine the level of catastrophic health expenditure (CHE), identify associated factors and coping strategies among patients attending cancer treatment services in Addis Ababa, Ethiopia. Methods: A hospital based cross-sectional survey of patients with cancer was conducted in public and private hospitals between January and March 2018. Data was collected using a structured questionnaire. All direct medical and nonmedical expenditures were measured and reported as expenditure (US$) per patient (1US$ equivalent to 23.41 Ethiopian Birr). The CHE was estimated using a threshold of 10% of annual household income. Results: A total of 352 (response rate of 87.1%) participants were interviewed. Majority (73.3%) of the respondents were females; most (94%) from public hospitals and their mean (±SD) age was 48±13.2years. Breast (37%) and Cervical (16.5%) cancers accounted the largest proportion. Vast majority (74.4%) of patients experienced CHE with mean overall expenditure of $2366 per patient (median: $1708). Medical expenditure shared the highest overall expenditure (83.6%) with mean medical and nonmedical costs of $1978 (median: $1394) and $388 (median: $222), respectively. Patients who took greater than six cycles of chemotherapy (AOR: 3.64; 95%CI: 1.11-11.92), and age (AOR: 1.03; 95%CI: 1.01-1.06) were significantly associated with CHE. Household saving (85.5%) followed by financial support (43.0%) were the main coping strategies. Conclusion: A substantial number of patients with cancer are exposed to CHE with considerable medical expenditure. Hence, mobilizing the health insurance scheme is urgently needed to ensure financial risk protection and realize universal health coverage for patients with cancer.