bluuebunny/crossref_metadata_2025_split huggingface dataset:
ABO Blood Group and Risk Associated With Sepsis-Associated Thrombocytopenia: A Single-Center Retrospective Study
Authors: Liufu Rong , Chen Yan , Wang Jing-Yi , Wang Yang-Yan-Qiu , Wu Yao , Jiang Wei , Wang Chun-Yao , Peng Jin-Min , Weng Li , Du Bin 
Published: November 2024

OBJECTIVES:
This study aimed to investigate the relationship between ABO blood group and sepsis-associated thrombocytopenia (SAT).

DESIGN AND SETTING:
The primary outcome was SAT within the first 72 hours of ICU admission.

PATIENTS:
The retrospective study included 9113 patients diagnosed with sepsis from January 2014 to December 2022. A total of 6296 patients eventually were included into the study, who were divided into four groups based on ABO blood group.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
A total of 2494 patients (39.6%) were diagnosed with SAT, and 712 (11.3%) of them experiencing severe SAT. The occurrence of SAT among the ABO blood groups was significantly lower in AB blood group compared with the other groups (p = 0.032). Individuals in AB blood group were less likely to experience severe SAT (p = 0.028). In multivariate analysis, B blood group (odds ratio [OR], 1.32; 95% CI, 1.05–1.67) and O (OR, 1.37; 95% CI, 1.09–1.72) were significantly associated with a higher occurrence of SAT compared with AB blood group. In multivariate analyses, A blood group (OR, 1.68; 95% CI, 1.16–2.42), B blood group (OR, 1.74; 95% CI, 1.74–2.50), and O blood group (OR, 1.72; 95% CI, 1.20–2.48) remained significantly risk factors associated with a higher occurrence of severe SAT compared with AB blood group.

CONCLUSIONS:
B blood group and O were associated with an increased risk of SAT and severe SAT.
The harmony of proportions: Exploring the golden ratio concept in nipple-sparing mastectomy through inframammary fold incision
Authors: Kaciulyte Juste , Sordi Silvia , Luridiana Gianluigi , Marcasciano Marco , Lo Torto Federico , Cavalieri Enrico , Cuomo Roberto , Ribuffo Diego , Casella Donato 
Published: November 2024

Background:
The inframammary incision appears promising in nipple-areola-sparing mastectomies (NASM). The Golden Ratio principles may standardize the extension and position of this incision, placing it in the lateral 2/3 of the fold. The authors explored the inframammary approach within the Golden Ratio concepts, to standardize its usage.

Methods:
This prospective study enrolled breast cancer patients eligible for NASM and implant-based breast reconstruction, excluding those with medium-severe breast ptosis. Incision lied in fold’s lateral 2/3 with a 1.618 ratio. Patient demographics, tumor characteristics, surgical complications, and aesthetic outcomes were recorded, with a minimum follow-up of 6 months.

Results:
A total of 108 patients were enrolled between August 2019 and December 2023. The inframammary fold averaged 11.8 cm, while the medium incision length was 7.3 cm. During an average follow-up of 20 months (range 6–47), six cases (5.5%) showed early postoperative complications. Two cases of severe capsular contracture necessitated implant replacement, and 4.6% of patients (5) developed rippling. Locoregional recurrence occurred in one case (0.9%). Aesthetic satisfaction scores were high: breast shape average score was 4.3, breast volume was 4.23, inframammary fold position was 4.1, and scar position was 4.8.

Conclusions:
NASM coupled with implant-based breast reconstruction allows the surgeon to focus on oncological safety without compromising aesthetic outcomes. As in all surgical procedures, patient selection is paramount, as well as thorough preoperative planning. To give an answer to “when,” “where” and “how” performing an inframammary incision in NASMs, the authors used the Golden Ratio principle achieving natural-looking reconstruction and high levels of patient satisfaction.
Management of Tomographically Suspicious Fellow Eyes of Young Patients With Unilateral Clinically Evident Keratoconus: Accelerated Epithelium-On Corneal Crosslinking Versus Observation
Authors: Abdel-Radi Mahmoud , Anwar Mohamed , Aly Momen Ahmad Mohammad , Eata Wael El Shazly , Goda Islam 
Published: November 2024

Purpose:
To investigate the effectiveness and safety of accelerated epithelium-on crosslinking to stabilize tomographically suspicious fellow eyes of young patients with unilateral clinically evident keratoconus (KC) compared with observation alone.

Methods:
This retrospective observational study included 43 fellow eyes of 43 young patients with unilateral clinically evident KC who completed a 24-month follow-up. Twenty-four eyes underwent accelerated epithelium-on crosslinking [epi-on corneal crosslinking (CXL) group] and 19 eyes were observed (observation group). A third healthy control group was added for comparison. The primary outcome measures were tomographic parameters and topometric indices assessed by pentacam. Secondary outcome measures included corneal ectatic progression defined as 1-diopter or more increase in maximum or steep keratometry (Kmax or K2), visual & refractive outcomes, and complications.

Results:
Baseline demographic and tomographic characteristics were similar between the epi-on CXL and observation groups (P > 0.05). Almost all mean tomographic parameters and topometric indices showed insignificant differences between baseline and after 24 months in the epi-on CXL and control groups (P > 0.05), whereas a significant progression was documented in the observation group (P < 0.05). At the end of the follow-up, progression was documented in 1 eye (4.2%) and in 8 eyes (42.1%) in the epi-on CXL and observation groups, respectively. Visual and refractive outcomes were more favorable in the epi-on CXL group. No significant complications were reported after accelerated epi-on CXL.

Conclusions:
Accelerated epithelium-on CXL was safe and achieved better tomographic stability and less corneal ectatic progression in tomographically suspicious fellow eyes of young patients with unilateral clinically evident keratoconus compared with observation alone.
Is minimally invasive glaucoma surgery killing trabeculectomies?
Authors: Loon Seng Chee , Ang Bryan Chin Hou , White Andrew 
Published: November 2024

Purpose of review
The introduction of minimally invasive glaucoma surgery (MIGS) has changed the surgical landscape of glaucoma surgery. For more than four decades, the most commonly performed glaucoma surgery around the world has been the trabeculectomy. This article examines whether trabeculectomy is still the predominant procedure in glaucoma today, in the context of rapidly emerging MIGS devices and procedures.

Recent findings
There is a growing trend of mild to moderate glaucoma cases undergoing MIGS procedures instead of trabeculectomy. Glaucoma drainage device implantation may also have taken away a significant share of the filtering surgery performed for more severe glaucoma. In addition, the availability and economics of implants has an influence on the prevalence of trabeculectomy.

Summary
Currently, trabeculectomy surgery is still the most common glaucoma surgery performed around the world. However, the proportion of glaucoma surgeries undergoing MIGS is increasing rapidly.
Development of a Smartphone-Based Self-Management Application for Patients With Left Ventricular Assist Devices
Authors: Shin Nara , Yoo Hye Jin 
Published: November 2024

Background
For patients with left ventricular assist devices, self-management is essential for maintaining health. A smartphone-based self-management application may help them practice self-management.

Objective
In this study, we aimed to develop an application to facilitate the self-management of patients with left ventricular assist devices and evaluate its usability.

Methods
A group of investigators developed a smartphone-based self-management application using the ADDIE model, between March and July 2023 in South Korea. Ten healthcare professionals and 5 pairs of patients with left ventricular assist devices and their family caregivers used the application for 5 days. The application's usability was verified using the Mobile Application Rating Scale and the user version of this scale. The participants' evaluations of the experience of using the application were collected using semistructured interviews.

Results
The application was composed of functions such as self-management information and a health diary. The score for application usability was 4.6 of 5 on both scales. Two themes were derived from qualitative interviews: “establishment of an essential self-management system for patients with LVADs” and “suggestions to make the app tailored to the patient.”

Conclusions
The developed application's usability was highly evaluated in quantitative and qualitative aspects. Therefore, introducing this application into healthcare could be a useful strategy to help patients improve their self-management.
Nipple-areolar complex sensory recovery based on incision placement after nipple-sparing mastectomy: a prospective nonrandomized controlled trial
Authors: Kook Yoonwon , Kim Dooreh , Park Soeun , Chu Chihhao , Jang Ji Soo , Baek Seung Ho , Bae Soong June , Ahn Sung Gwe , Jeong Joon 
Published: November 2024

Introduction:
Nipple-sparing mastectomy (NSM) aims to improve patient satisfaction by preserving the nipple-areola complex (NAC) while ensuring oncologic safety. Different surgical incisions, such as inframammary fold (IMF) and periareolar/radial incisions, are used in NSM; however, their impact on NAC sensory loss remains unclear. In this study, the authors aimed to assess NAC sensation after NSM and compare the results of different incisional approaches, specifically IMF versus periareolar/radial.

Methods:
In this prospective, single-center, nonrandomized controlled trial, 105 post-NSM patients were recruited from October 2019 to November 2021 and followed up at 24–48 months postsurgery. Of these, 97 (IMF: 65; periareolar/radial: 32) were analyzed for sensory assessment. NAC sensation was measured using the pin-prick test, with scores ranging from 0 (no sensation) to 2 (sharp sensation) across five NAC areas. Sensory loss was defined as a total score below 3.

Results:
The median total score on the pin-prick test for NAC sensation was significantly higher in the IMF incision group than in the periareolar/radial incision group (3.77±3.11 vs. 2.47±2.51; P=0.043). The rate of NAC sensory loss was significantly lower in the IMF group than in the periareolar/radial group (36.9% vs. 62.5%; P=0.017). Multivariable analysis revealed that the incisional approach (95% CI: 0.14–0.97; P=0.044) and radiotherapy (95% CI: 0.05–0.36; P<0.01) were independent determinants of NAC sensory loss.

Conclusion:
Our study emphasized the importance of incision placement during NSM in preserving NAC sensation and may provide a valuable perspective for clinicians and patients considering this surgical approach.
The role of fluorescent cholangiography to improve operative safety in different severity degrees of acute cholecystitis during emergency laparoscopic cholecystectomy: a prospective cohort study
Authors: Pesce Antonio , Fabbri Nicolò , Bonazza Luca , Feo Carlo 
Published: November 2024

Background:
Currently, there is limited scientific evidence regarding the effectiveness of fluorescent cholangiography in emergency cholecystectomy for acute cholecystitis. The primary aim of this study was to assess the efficacy of near-infrared fluorescent cholangiography (NIRF-C) in different severity degrees of acute cholecystitis.

Materials and methods:
Inclusion criteria were patients with a clinical and radiological (abdominal ultrasound and/or computed tomography) diagnosis of acute cholecystitis based on the revised 2018 Tokyo guidelines who underwent laparoscopic cholecystectomy within 24–72 h from the onset of symptoms and patients with ASA score of 0–3. NIRF-C was performed at three-time points during laparoscopic cholecystectomy: (i) following exposure of Calot’s triangle, prior to any dissection; (ii) after partial dissection of Calot’s triangle; and (iii) after complete dissection of Calot’s triangle. The intraoperative severity degree of acute cholecystitis was assessed according to the American Association of Surgery for Trauma (AAST) classification.

Results:
NIRF-C was successfully performed in all 81 consecutive patients who underwent emergency laparoscopic cholecystectomy. The cystic duct was identified by NIRF-C in 46 (56.8%) and 77 (95.1%) of the 81 patients before and after Calot’s dissection, respectively. The common hepatic duct and common bile duct were successfully identified in 11 (13.6%) and 32 patients (39.5%) before Calot’s dissection, respectively, and in 45 (55.6%) and 76 patients (93.8%) after complete Calot’s dissection, respectively. When comparing the visualization rate of biliary structures before and after Calot dissection in different severity degrees of cholecystitis, the authors found a statistically significant difference in nongangrenous (AAST I) versus gangrenous and complicated forms (AAST II–V) for all biliary structures, both before and after Calot’s dissection.

Conclusions:
The study indicates that the use of fluorescence cholangiography during emergency laparoscopic cholecystectomy for acute cholecystitis may represent a valuable and useful tool for intraoperative visualization of the extrahepatic biliary tract.
Biceps Femoris Long Head Fascicle Length Not Associated With Hamstring Injury Risk in NCAA Football Athletes
Authors: Krystofiak Jason , Asselstine Sydney , Toto Diana , Rybak Katelan , Zhao Yihong , Misuraco Anthony , McCune David 
Published: November 2024

Objective:
To determine whether biceps femoris long head (BFlh) fascicle length (FL) is related to hamstring injury (HSI) risk in collegiate football athletes.

Design:
Retrospective cohort.

Setting:
University athletic medical center.

Participants:
Division I Collegiate football athletes (n = 129, age = 20.03 ± 1.68 years, body mass index = 29.50 ± 5.06 kg/m2).

Interventions:
Biceps femoris long head FL measurements were previously taken on the nondominant leg of each athlete. Presence or absence of HSI for 2 playing seasons and training camps was evaluated through retrospective review of medical records.

Main Outcome Measures:
Whether a shorter BFlh FL was associated with increased risk for any HSI.

Results:
Biceps femoris long head FL was not associated with HSI risk. Body mass index ≥30 kg/m2 was incidentally found to be protective (odds ratio = 0.27, 95% confidence interval, 0.08–0.84, P = 0.03).

Conclusions:
Biceps femoris long head FL is not an ideal measurement for predicting risk of HSI in American football athletes.
Risk of Home Falls Among Older Adults After Acute Care Hospitalization: A Cohort Study
Authors: Adams Christy M. , Tancredi Daniel J. , Bell Janice F. , Catz Sheryl L. , Romano Patrick S. 
Published: November 2024

BACKGROUND:
Acute care hospitalization has been associated with older adult home falls after discharge, but less is known about the effects of hospital- and patient-related factors on home fall risk.

OBJECTIVES:
This study compares the effects of hospital length of stay, medical condition, history of falls, and home health care on period rates of home falls after discharge from acute care hospitalization.

METHODS:
This was a retrospective cohort study comparing period rates of home injury falls among older adults (age ≥ 65) occurring after discharge from an acute care hospitalization. Data were collected from state health care utilization administrative records between January 1, 2016, and December 31, 2018. We used log-linear Poisson regression to model post-discharge injury fall incidence rates as a function of days since discharge and patient-level covariates.

RESULTS:
A total of 736,230 older adults were included in the study cohort. Absolute risk for post-discharge home falls was 7%. Fall rates were highest the first week after discharge at 0.05 per 100 person-days, with a period incidence rate 74.29 times higher than the >90-day discharge period. Fall risk increased with age, with the highest risk in the ≥85 age group. Fall risk increased for a 2-day hospital stay but decreased for 5- to 30-day stays, compared to a 1-day length of stay. Discharge to home health care and history of falls were associated with increased risk.

CONCLUSIONS:
Older adults are at highest risk for a home fall the first 7 days after discharge from acute care hospitalization. These findings describe patient-related risk factors that acute care hospitals can use to develop geriatric-specific discharge guidelines intended to reduce home fall risk during the early care transition to home.
How Does Transitioning to Primary Human Papillomavirus Screening Impact Colposcopy Services? Lessons From an Australian National Program
Authors: Jennett Chloe J. , Smith Megan A. , Machalek Dorothy A. , Sultana Farhana , Prang Khic-Houy , McDermott Tracey , Nightingale Claire E. , Zammit Claire M. , Pagotto Amy , Rankin Nicole M. , Wrede C. David H. , Brotherton Julia M. L. 
Published: November 2024

Objective
In 2017, Australian's National Cervical Screening Program changed from 2-yearly cytology to 5-yearly primary human papillomavirus (HPV) testing. The Stakeholder Opinions of Renewal Implementation and Experiences Study (STORIES) aimed to capture stakeholder perspectives during implementation of the renewed National Cervical Screening Program.

Materials and Methods
Qualitative semistructured interviews were conducted with key National Cervical Screening Program stakeholders 11–20 months following the change, either face-to-face, online, or via phone. Data related to colposcopy services were thematically analyzed using Proctor's conceptual framework for implementation outcomes.

Results
We identified 4 overarching themes: non-adherence to guidelines, lack of preparedness, unintended consequences, and mitigation strategies. While an initial increase in colposcopy referral was expected following transition, many stakeholders found increased referrals to be inequitably spread across services and exacerbated by confusion about, or overuse of testing for, symptoms.

Conclusions
The study provides the first assessment of stakeholder perceptions and experiences relating to colposcopy services during a transition from cytology to HPV screening. Significant preparation is required to ensure equitable and timely access to colposcopy when transitioning cervical screening programs, including wide stakeholder communication to build confidence; clear guidelines, especially around symptoms; and adequate resourcing for colposcopy services to meet projected referral rates.
Dry Needling Plus Cervical Interlaminar Epidural Steroid Injections: Do We Have More Favorable Results in Cervical Disc Herniation? A Randomized Sham-Controlled Clinical Study
Authors: Yolcu Günay , Toprak Canan Sanal , Sencan Savas , Gunduz Osman Hakan 
Published: November 2024

Objective
Trigger point-related myofascial pain commonly accompanies cervical disc herniation. The aim of the study is to investigate the effect of dry needling for accompanying trigger points on cervical interlaminar epidural steroid injection treatment outcomes.

Design
Among the patients scheduled for interlaminar epidural steroid injection for cervical disc herniation, those with active trigger points were randomly divided into three groups: interlaminar epidural steroid injection + dry needling, interlaminar epidural steroid injection + sham dry needling, and only interlaminar epidural steroid injection group. Outcome measures were determined as the change in Numeric Rating Scale, number of active trigger points, and the pressure-pain threshold measurement.

Results
A total of 66 patients, 22 per group, were included in the final evaluation. While significant decrease in Numeric Rating Scale scores was observed in all three groups at 3rd week and 3rd month, this decrease was significantly more pronounced in the interlaminar epidural steroid injection + dry needling group (P < 0.001). There was a significant decrease in the number of active trigger points in all three groups (P < 0.001). While a significant increase was observed in the pressure-pain threshold value only in the interlaminar epidural steroid injection + dry needling group at the 3rd week, this increase was found to be significant in all three groups at the 3rd month (P < 0.001).

Conclusions
Combination therapy with dry needling has superiority to interlaminar epidural steroid injection + sham dry needling and only interlaminar epidural steroid injection groups in reducing pain and increasing pressure-pain threshold values.
Migration is Associated With Increased HIV Vulnerability Among Young Transgender Women in Lima, Peru
Authors: Perez-Brumer Amaya , Apedaile Dorothy , León-Morris Franceska , Huerta Leyla , Leon Segundo , Konda Kelika , Reisner Sari L. , Silva-Santisteban Alfonso 
Published: November 2024

Background:
Latin America—amid its largest mass migration—has seen minimal progress in curbing new HIV infections. Transgender women (TW) in the region are disproportionately affected, but scant data examine HIV vulnerabilities alongside migration.

Methods:
Between February and July 2022, 211 young TW ages 16–24 in Lima participated in a cross-sectional quantitative study accompanied by serological testing (HIV, syphilis, chlamydia, gonorrhea, hepatitis B). Bivariate tests compared HIV and STI prevalence and related vulnerabilities among migrants to nonmigrants. Poisson regression modeling estimated the association between time in Lima (nonmigrant, 0–1 years, 2–5 years, ≥6 years) and HIV vulnerabilities (condom use).

Findings:
Of 204 young TW, 110 were migrants to Lima (54%); 45% arrived in Lima ≤5 years ago. Most migrants were Peruvian (70% from Jungle regions); 14% were from Venezuela. HIV prevalence was 44% among migrants and 39% among nonmigrants (P = 0.67). Compared with nonmigrants, migrants had higher prevalence of lifetime syphilis (65% vs 41%; P < 0.01) and poor health care access (29% vs 12% no medical insurance), lifetime sex work (78% vs 55%; P < 0.01) and sex work in past 30 days, (42% vs 8%; P < 0.01), and client violence (23% vs 6%; P < 0.01). Migrants arriving in Lima 0–1 years ago were more likely to report past 6-month condomless anal sex compared with nonmigrants (adjusted prevalence ratio = 1.54; 95% confidence interval = 1.02 to 2.32).

Conclusions:
Young TW face high rates of HIV and STIs, with vulnerabilities persisting even after resettlement for migrants. There is an urgent need for expanded HIV prevention and care for these women and sustained health and social services for migrants in urban centers postmigration.
Publishing a Plastic Surgery Paper
Authors: Lineaweaver William C. , Chaker Sara C. , Saad Mariam , Torres-Guzman Ricardo , James Andrew J. , Nemani Sriya 
Published: November 2024

Abstract
This article provides a roadmap for plastic surgeons on how to successfully conceptualize, draft, and publish a paper. By publishing papers, authors will not only add to their professional standings but gain a deeper understanding of their topics and become artful at communicating their expertise to others. The processes of composition, submission, and revisions of manuscripts are an interlocking set of steps, and this essay describes the steps and their relationships to each other and final successful publications.
Advances and Challenges in Zone 2 Flexor Tendon Repairs
Authors: Wimbiscus Mae , Sullivan Lauren , Lee Justin , Vinson Ariel , Torres-Guzman Ricardo A. , Stehr Justin , Bhandari Laxminarayan 
Published: November 2024

Abstract
Flexor zone 2 is the area between the A1 pulley at the distal palmar crease to the insertion of the flexor digitorum superficialis tendon at A4 pulley. Termed “no man's land,” primary repair at zone 2 had notoriously high rate of complications such as adhesions, contractures, and tendon rupture. Improved understanding of tendon healing, stronger suture materials, novel operative techniques, judicious pulley venting, and early active rehabilitation have helped improve outcomes. This review examines current methodologies and postoperative considerations for zone 2 flexor tendon repair.