bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐reported knee instability associated with pain, activity limitations, and poorer quality of life before and 1 year after total knee arthroplasty in patients with knee osteoarthritis
Authors: Leichtenberg Claudia S. , Vliet Vlieland Thea P. M. , Kroon Herman M. , Dekker Joost , Marijnissen Willem Jan , Damen Pieter‐Jan , Nelissen Rob G. H. H. , van der Esch Martin ,   On behalf of the LOAS Studygroup
Published: May 2018

ABSTRACTInformation on the association of self‐reported knee instability with clinical outcomes after Total Knee Arthroplasty (TKA) and 1 year follow‐up is scarce. The aims were to determine (i) the course and prevalence of self‐reported knee instability before and 1 year after TKA and (ii) the associations of preoperative, postoperative, and retained self‐reported knee instability with pain, activity limitations, and quality of life (QoL) in patients with knee osteoarthritis. Patients undergoing primary TKA, selected from the Longitudinal Leiden Orthopaedics and Outcomes of OsteoArthritis Study, had their knee instability measured using a questionnaire. The Knee injury and Osteoarthritis Outcome Score pain, activity limitations, and QoL subscales were administered before and 1 year after surgery. Multivariable regression analyses were performed to examine associations between knee instability, pain, activity limitations, and QoL, adjusted for covariates (age, gender, comorbidities, and radiographic severity). Of the 908 included patients, 649 (71%) and 187 (21%) reported knee instability before and following TKA, respectively. Of the patients with preoperative knee instability, this perception was retained in 165 (25%) cases. Knee instability was preoperatively associated with pain (B −9.6; 95%CI: −12.4 to −6.7), activity limitations (B −7.5; 95%CI: −10.2 to −4.8), and QoL (B −4.7; 95%CI: −7.0 to −2.4) and postoperatively with pain (B −15.0; 95%CI: −18.5 to −11.6), activity limitations (B −15.1; 95%CI: −18.4 to −11.8), and QoL (B −18.7; 95%CI: −22.3 to −15.3). Retained knee instability was associated with postoperative pain (B −15.1; 95%CI: −18.9 to −11.2), activity limitations (B −14.1; 95%CI: −17.8 to −10.4), and QoL (B −18.0; 95%CI: −21.7 to −14.3). In conclusion, in clinical care, self‐reported knee instability is retained postoperatively in 25% of the patients. Retained knee instability is associated with more pain, activity limitations, and poorer QoL postoperatively. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2671–2678, 2018
Walking velocity and step length adjustments affect knee joint contact forces in healthy weight and obese adults
Authors: Milner Clare E. , Meardon Stacey A. , Hawkins Jillian L. , Willson John D. 
Published: May 2018

ABSTRACTKnee osteoarthritis is a major public health problem and adults with obesity are particularly at risk. One approach to alleviating this problem is to reduce the mechanical load at the joint during daily activity. Adjusting temporospatial parameters of walking could mitigate cumulative knee joint mechanical loads. The purpose of this study was to determine how adjustments to velocity and step length affects knee joint loading in healthy weight adults and adults with obesity. We collected three‐dimensional gait analysis data on 10 adults with a normal body mass index and 10 adults with obesity during over ground walking in nine different conditions. In addition to preferred velocity and step length, we also conducted combinations of 15% increased and decreased velocity and step length. Peak tibiofemoral joint impulse and knee adduction angular impulse were reduced in the decreased step length conditions in both healthy weight adults (main effect) and those with obesity (interaction effect). Peak knee joint adduction moment was also reduced with decreased step length, and with decreased velocity in both groups. We conclude from these results that adopting shorter step lengths during daily activity and when walking for exercise can reduce mechanical stimuli associated with articular cartilage degenerative processes in adults with and without obesity. Thus, walking with reduced step length may benefit adults at risk for disability due to knee osteoarthritis. Clinical Significance: Adopting a shorter step length during daily walking activity may reduce knee joint loading and thus benefit those at risk for knee cartilage degeneration. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2679‐2686, 2018
Priming to protect maize from Fusarium verticillioides and its fumonisin accumulation
Authors: Aguado Ana , Savoie Jean‐Michel , Chéreau Sylvain , Ducos Christine , Aguilar María , Ferrer Nathalie , Aguilar Manuel , Pinson‐Gadais Laetitia , Richard‐Forget Florence 
Published: May 2018

AbstractBACKGROUNDSystemic infection through the seed is one of the routes used by the mycotoxinogenic pathogen Fusarium verticillioides for colonizing maize plants. The prohibition of the use of most chemical fungicides by the EU has promoted research on plant resistance inducers as an effective and sustainable alternative. Induction of a priming state in maize seeds might affect their susceptibility to contamination and accumulation of fumonisins. This state by application of a natural fertilizer called Chamae on maize seeds, was investigated in two varieties to control the colonization by the fungus and the accumulation of fumonisins B1, B2 and B3, germinating seeds, dead plants and yield.RESULTSAfter inoculation of F. verticillioides on germinating seeds, the colonization by the fungus and the accumulation of fumonisins were significantly lower in seedlings coming from treated seeds, but a significant number of plants stopped their development by necrosis. In a field trial, the 0.01% (v/v) application dilution showed a lower plant density, although the level of biomass at harvest was not affected.CONCLUSIONThe priming state contributed to the control of F. verticillioides development from seed infection and fumonisin
accumulation in the early stage of plant growth, without affecting the final crop yield, and could reduce fungicide use and environmental contamination. © 2018 Society of Chemical Industry
Comparison of five methods for the estimation of methane production from vented in vitro systems
Authors: Alvarez Hess Pablo S , Eckard Richard J , Jacobs Joe L , Hannah Murray C , Moate Peter J 
Published: May 2018

AbstractBACKGROUNDThere are several methods for estimating methane production (MP) from feedstuffs in vented in vitro systems. One method (A; ‘gold standard’) measures methane proportions in the incubation bottle's headspace (HS) and in the vented gas collected in gas bags. Four other methods (B, C, D and E) measure methane proportion in a single gas sample from the HS. Method B assumes the same methane proportion in the vented gas as in the HS, method C assumes constant methane to carbon dioxide ratio, method D has been developed based on empirical data, and method E assumes constant individual venting volumes. This study aimed to compare the MP predictions from these methods to that of the gold standard method under different incubation scenarios, to validate these methods based on their concordance with a gold‐standard method.RESULTSMethods C, D and E had greater concordance (0.85, 0.88 and 0.81), lower root‐mean‐square error (RMSE; 0.80, 0.72 and 0.85) and lower mean bias (0.20, 0.35, −0.35) with the gold standard than did method B (concordance 0.67, RMSE 1.49 and mean bias 1.26). Methods D and E were simpler to perform than method C, and method D was slightly more accurate than method E.CONCLUSIONBased on precision, accuracy and simplicity of implementation, it is recommended that, when method A cannot be used, methods D and E are preferred to estimate MP from vented in vitro systems. © 2018 Society of Chemical Industry
Preparation and purification of canthinone and β‐carboline alkaloids from Picrasma quassioides based on bioautography and mass‐spectrometry‐directed autopurification system
Authors: Yang Na , Shi Yanhong , Xiong Aizhen , Zhou Yue , Gu Lihua , Wang Rui , Yang Li , Wang Zhengtao 
Published: May 2018

AbstractPicrasma quassioides (D. Don) Benn. is a widely used traditional Chinese medicine for anti‐inflammation and antibiosis. Canthinone and β‐carboline alkaloids are the main characteristic constituents that possess diverse pharmacological effects, such as anti‐inflammatory and anti‐infectious properties. In this study, bioautography in thin‐layer chromatography indicated that the antiradical activity compound may be alkaloids. Then, a simple, fast, and efficient method was established for the separation and purification of two types of alkaloids from P. quassioides by mass‐spectrometry‐directed autopurification system. Eight alkaloids were isolated and purified in this one‐step methodology. Among them, five compounds (3, 95.1%, 58.8 mg; 4, 98.4%, 71.7 mg; 6, 97.8%, 365.4 mg; 7, 97.7%, 172.7 mg; 8, 98.2%, 180.3 mg) were obtained in large amounts with extremely high purities. Then, the antiradical activities of the isolates showed that 4‐methoxy‐5‐hydroxycanthin‐6‐one (6) exhibited obvious 1,1‐diphenyl‐2‐picryl‐hydrazyl free radical scavenging activity with an IC50 value of 84.037 μM. This study offers a new method for the preparation of targeted bioactive alkaloids in P. quassioides. This work also provides a reference for the separation of other targeted chemical components with potential activities from traditional Chinese herbal medicines.
Obesity‐Associated Diseases Biomarkers Are Differently Modulated in Lean and Obese Individuals and Inversely Correlated to Plasma Polyphenolic Metabolites After 6 Weeks of Mango (Mangifera indica L.) Consumption
Authors: Fang Chuo , Kim Hyemee , Barnes Ryan C. , Talcott Stephen T. , Mertens‐Talcott Susanne U. 
Published: May 2018

ScopeMangos are a rich source of gallotannin‐derived polyphenols that may exert anti‐inflammatory effects relevant to obesity‐related chronic diseases. This randomized human clinical study investigated the influence of daily mango supplementation for 6 weeks on inflammation and metabolic functions in lean and obese individuals.Methods and resultsLean (n = 12, body mass index [BMI] 18–26.2 kg m−2) and obese (n = 9, BMI >28.9 kg m−2) participants, aged 18–65 years received daily 400 g of mango pulp for 6 weeks. Inflammatory cytokines, metabolic hormones, and lipid profiles were examined in plasma before and after 6 weeks. In lean participants, systolic blood pressure was lowered by 4 mmHg after 6 weeks. In obese participants, hemoglobin A1c (HbA1c) and plasminogen activator inhibitor‐1 (PAI‐1) were reduced by 18% and 20%, respectively. Obese participants showed decreased plasma concentrations (area under the curve [AUC] 0–8h) of interleukin‐8 (IL‐8) and monocyte chemoattractant protein‐1 (MCP‐1). Correlation analysis indicates that the beneficial effects of mango supplementation on pro‐inflammatory cytokines, PAI‐1 and HbA1c, are associated with systemic exposure to polyphenolic metabolites.ConclusionsMango supplementation improves the plasma levels of pro‐inflammatory cytokines and metabolic hormones in obese participants. There is a crucial need to investigate the role of lowered polyphenolic absorption in obese individuals on their efficacy in reducing biomarkers for inflammation and other risk factors for chronic diseases.
Repetitive transcranial magnetic stimulation for chronic neuropathic pain in patients with bladder pain syndrome/interstitial cystitis
Authors: Cervigni Mauro , Onesti Emanuela , Ceccanti Marco , Gori Maria C. , Tartaglia Giorgio , Campagna Giuseppe , Panico Giovanni , Vacca Lorenzo , Cambieri Chiara , Libonati Laura , Inghilleri Maurizio 
Published: May 2018

AimsTo evaluate the efficacy, safety, and tolerability of repetitive Transcranial Magnetic Stimulation (rTMS) associated with standard drug therapies for neuropathic pain that does not respond to pharmacological treatment alone in patients with Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC). Secondary goals were to assess the effects of rTMS on Lower Urinary Tract Symptoms (LUTS) and Quality of Life (QOL).MethodsFifteen patients with BPS/IC were enrolled in this randomized, double‐blind, sham stimulation‐controlled, crossover study. Patients were treated for 2 weeks with either real‐rTMS (for five consecutive days in 20‐min sessions) or sham‐rTMS (for five consecutive days in 20‐min sessions). After a 6‐week washout period, the patients who had previously undergone real‐rTMS underwent sham‐rTMS, and vice versa. Patients were rated at each visit by means of questionnaires on pain, urinary disturbances, depression, and QOL.ResultsThe statistical analysis revealed significant effects of real‐rTMS, when compared with sham‐rTMS, on pain (in the VAS, Functional Neuropathic Pelvic Pain, Neuropathic Pain Symptom Inventory, McGill questionnaire, and Central Sensitization Inventory), urinary LUTS (in the Overactive Bladder Questionnaire score, bladder emptying, and daily urinary frequency), and QOL (in the subscores of the SF‐36 related to physical pain and to emotional status). No serious adverse events were reported during the study.ConclusionsThe results of this study show that rTMS applied with an H‐coil over the M1 in the area corresponding to the pelvic region in patients with BPS/IC appears to improve chronic pelvic pain (CPP) and associated urinary disorders.
Probe generation for active probing
Authors: Dusia A. , Sethi A. S. 
Published: May 2018

SummaryActive probing is a widely adopted approach for developing effective solutions for network monitoring and diagnosing. However, the use of probing techniques incurs costs in terms of additional network traffic. Furthermore, probing stations are required to be configured and maintained in the network for sending out probes. The set of probes used for fault detection and/or diagnosis (called the target probe set) is selected by a probe selection algorithm from a larger set called the candidate probe set. Most of the existing techniques for selecting the target probe set assume that the candidate probe set will preexist and the set is determined by the configured routing model in the network. In this paper, we address the problem of generating an expanded candidate probe set, which results in the selection of a more efficient target probe set. We propose the use of heuristics and network partitioning strategies for generating the candidate probe set. For evaluating our approach, we perform experiments to generate candidate probe sets for the networks of several types and sizes. The candidate probe sets are used by the existing probe selection algorithms for selecting target probe sets for fault detection and localization. Our results demonstrate that the target probe set selected from the candidate probe set generated using our approach has a reduced cost of monitoring the network.
Does the Immigrant Advantage in Overweight/Obesity Persist over Time in Mexican American Youth? NHANES 1988‐1994 to 2005‐2014
Authors: Maldonado Luis E. , Albrecht Sandra S. 
Published: May 2018

ObjectiveTo examine whether the relationship between nativity and overweight/obesity has changed over time among Mexican American children and to investigate the implications of this pattern on overweight/obesity disparities relative to non‐Hispanic white children.MethodsUsing cross‐sectional data from Mexican American and non‐Hispanic white children aged 4 to 17 years participating in the National Health and Nutrition Examination Surveys (1988‐1994 [N = 4,720] and 2005‐2014 [N = 7,275]) log‐binomial regression was used to calculate prevalence ratios (PRs) of overweight/obesity by nativity status adjusting for sociodemographic covariates, survey period, and a nativity‐by‐survey period interaction. A separate covariate‐adjusted model tested a three‐level interaction between ethnicity, nativity, and survey period that included non‐Hispanic white children.ResultsIn 1988‐1994, foreign‐born Mexican Americans had significantly lower prevalence of overweight/obesity compared with US‐born Mexican Americans (PR = 0.75, 95% CI: 0.61‐0.94). However, by 2005‐2014, the nativity gap in overweight/obesity had closed (PR = 0.94, 95% CI: 0.84‐1.07). Moreover, while foreign‐born Mexican Americans had the lowest levels of overweight/obesity in 1988‐1994, by 2005‐2014, foreign‐born and US‐born Mexican Americans had comparable estimates, both significantly higher than that of non‐Hispanic white individuals.ConclusionsAlthough overweight/obesity disparities between Mexican Americans and non‐Hispanic white Americans had previously been specific to US‐born Mexican Americans, disparities in more recent years have extended to foreign‐born Mexican Americans.
Energy Expenditure in Pregnant Women with Obesity Does Not Support Energy Intake Recommendations
Authors: Most Jasper , Vallo Porsha M. , Gilmore L. Anne , St. Amant Marshall , Hsia Daniel S. , Altazan Abby D. , Beyl Robbie A. , Ravussin Eric , Redman Leanne M. 
Published: May 2018

ObjectiveThis study aimed to identify factors that may predispose women to excess gestational weight gain (GWG).MethodsSeventy‐two healthy women with obesity (30 class I, 24 class II, 18 class III) expecting a singleton pregnancy were studied at 13 to 16 weeks gestation. Energy expenditure (EE) was measured during sleep (SleepEE, average EE from 0200‐0500 hours) in a whole‐room calorimeter, and total daily EE (TDEE) over 7 days using doubly labeled water. Glucose, insulin, thyroid hormones, and catecholamines were measured.ResultsBody composition explained 70% variability in SleepEE, and SleepEE accounted for 67% to 73% of TDEE. Though there was no evidence of consistent low metabolism, there was considerable variability. Low SleepEE was associated with insulin resistance and low triiodothyronine concentrations (both P = 0.01). Physical activity level was 1.47 ± 0.02. For women with SleepEE within 100 kcal/d of their predicted EE, TDEE was significantly less than the estimate (2,530 ± 91 vs. 2,939 kcal/d; P < 0.001) provided from the most recent gestational energy requirement model.ConclusionsPregnant women with obesity are inactive, possibly predisposing them to excess GWG. Current energy requirement models overestimate activity and may promote excess GWG in women with obesity. Furthermore, the observed large interindividual variability in basal metabolism may be important to consider when assessing the risk for excess GWG.
Sickle Cell Clinical Research and Intervention Program (SCCRIP): A lifespan cohort study for sickle cell disease progression from the pediatric stage into adulthood
Authors: Hankins Jane S. , Estepp Jeremie H. , Hodges Jason R. , Villavicencio Martha A. , Robison Leslie L. , Weiss Mitchell J. , Kang Guolian , Schreiber Jane E. , Porter Jerlym S. , Kaste Sue C. , Saving Kay L. , Bryant Paulette C. , Deyo Jeffrey E. , Nottage Kerri A. , King Allison A. , Brandow Amanda M. , Lebensburger Jeffrey D. , Adesina Oyebimpe , Chou Stella T. , Zemel Babette S. , Smeltzer Matthew P. , Wang Winfred C. , Gurney James G. 
Published: May 2018

AbstractBackgroundPrevious natural history studies have advanced the understanding of sickle cell disease (SCD), but generally have not included sufficient lifespan data or investigation of the role of genetics in clinical outcomes, and have often occurred before the widespread use of disease‐modifying therapies, such as hydroxyurea and chronic erythrocyte transfusions. To further advance knowledge of SCD, St. Jude Children's Research Hospital established the Sickle Cell Clinical Research and Intervention Program (SCCRIP), to conduct research in a clinically evaluated cohort of individuals with SCD across their lifetime.ProceduresInitiated in 2014, the SCCRIP study prospectively recruits patients diagnosed with SCD and includes retrospective and longitudinal collection of clinical, neurocognitive, geospatial, psychosocial, and health outcomes data. Biological samples are banked for future genomics and proteomics studies. The organizational structure of SCCRIP is based upon organ/system‐specific working groups and is opened to the research community for partnerships.ResultsAs of August 2017, 1,044 (92.3% of eligible) patients with SCD have enrolled in the study (860 children and 184 adults), with 11,915 person‐years of observation. Population demographics included mean age at last visit of 11.3 years (range 0.7–30.1), 49.8% females, 57.7% treated with hydroxyurea, 8.5% treated with monthly transfusions, and 62.9% hemoglobin (Hb) SS or HbSB0‐thalassemia, 25.7% HbSC, 8.4% HbsB+‐Thalassemia, 1.7% HbS/HPFH, and 1.2% other.ConclusionsThe SCCRIP cohort will provide a rich resource for the conduct of high impact multidisciplinary research in SCD.
Late mortality and morbidity among long‐term leukemia survivors with Down syndrome: A nationwide population‐based cohort study
Authors: Vonasek Julia , Asdahl Peter , Heyman Mats , Källén Karin , Hasle Henrik 
Published: May 2018

AbstractBackgroundLate health consequences of treatment for childhood leukemia are well documented. Although individuals with Down syndrome (DS) have a substantially increased risk of leukemia, information on late effects in this group is almost nonexistent. The aim of this study was to evaluate the mortality and morbidity among 5‐year leukemia survivors with DS.ProcedureWe compared 5‐year leukemia survivors with leukemia‐free individuals with DS. All individuals born with DS in Denmark between 1960 and 2007 and in Sweden between 1973 and 2009 were included. Long‐term morbidity was estimated by comparing hospitalization rates between survivors and leukemia‐free individuals.ResultsIn total, we found 6,705 individuals with DS, 84 of whom were 5‐year survivors of leukemia. Survivors had a higher risk of death (hazard ratio [HR] 5.9; 95% confidence interval [CI]: 2.7–13) compared with leukemia‐free individuals. All deaths (n = 7) among 5‐year leukemia survivors were due to relapse. Survivors had a higher hospitalization rate (HR 4.4; 95% CI: 3.1–6.2). However, most of these hospitalizations were due to relapse. Censoring individuals who either had a relapse or were being treated for a relapse more than 5 years from the initial diagnosis (n = 9) attenuated the association (HR 1.4; 95% CI: 1.0–2.1).ConclusionIn this study, we found that relapse was the main reason for death and hospitalization among leukemia survivors with DS, and not late effects. These results are reassuring for individuals treated for DS associated with leukemia and their parents.