bluuebunny/crossref_metadata_2025_split huggingface dataset:
Group size and collective action in a binary contribution game
Authors: Nöldeke Georg , Peña Jorge 
Published: December 2018

AbstractWe consider how group size affects the private provision of a public good with non-refundable binary contributions. A fixed amount of the good is provided if and only if the number of contributors reaches an exogenous threshold. The threshold, the group size, and the identical, non-refundable cost of contributing to the public good are common knowledge. Our focus is on the case in which the threshold is larger than one, so that teamwork is required to produce the public good. We show that both expected payoffs and the probability that the public good is obtained in the best symmetric equilibrium are decreasing in group size. We also characterize the limit outcome when group size converges to infinity and provide precise conditions under which the expected number of contributors is decreasing or increasing in group size for sufficiently large groups.JEL classificationC72, D71, H41.
Medroxyprogesterone acetate mediated alteration in the vaginal microbiota and microenvironment in a Kenyan sex worker cohort
Authors: Wessels Jocelyn M. , Lajoie Julie , Hay Cooper Maeve I. J. , Omollo Kenneth , Felker Allison M. , Vitali Danielle , Dupont Haley A. , Nguyen Philip V. , Mueller Kristen , Vahedi Fatemeh , Kimani Joshua , Oyugi Julius , Cheruiyot Juliana , Mungai John N. , Deshiere Alexandre , Tremblay Michel J. , Mazzulli Tony , Stearns Jennifer C. , Ashkar Ali A. , Fowke Keith R. , Surette Michael G. , Kaushic Charu 
Published: December 2018

Abstract:The hormonal contraceptive Medroxyprogesterone Acetate (MPA) is associated with increased risk of Human Immunodeficiency Virus (HIV), via incompletely understood mechanisms. Increased diversity in the vaginal microbiota modulates genital inflammation and is associated with increased HIV-1 acquisition. However, the effect of MPA on diversity of the vaginal microbiota is relatively unknown. In a cohort of female Kenyan sex workers, negative for sexually transmitted infections (STIs), with Nugent Scores <7 (N=58 of 370 screened), MPA correlated with significantly increased diversity of the vaginal microbiota as assessed by 16S rRNA gene sequencing. MPA was also significantly associated with low vaginal glycogen and α-amylase, factors implicated in vaginal colonization by lactobacilli, bacteria believed to protect against STIs. Furthermore, increased diversity of the vaginal microbiota correlated with activation of vaginal HIV-1 target cells. Results were recapitulated in humanized mice where MPA treatment was associated with increased diversity of the vaginal microbiota, low glycogen, and enhanced HIV-1 susceptibility. Together these results suggest MPA-induced hypo-estrogenism may alter key metabolic components necessary for vaginal colonization by certain bacterial species including lactobacilli, and allow for greater bacterial diversity in the vaginal microbiota. Bacterial diversity in the vaginal microbiota correlates with activation of HIV-1 target cells, which might thus contribute to enhanced susceptibility to HIV-1.
ciftify: A framework for surface-based analysis of legacy MR acquisitions
Authors: Dickie Erin W. , Anticevic Alan , Smith Dawn E. , Coalson Timothy S. , Manogaran Mathuvanthi , Calarco Navona , Viviano Joseph D. , Glasser Matthew F. , Van Essen David C. , Voineskos Aristotle N. 
Published: December 2018

ABSTRACTThe preprocessing pipelines of the Human Connectome Project (HCP) were made publicly available for the neuroimaging community to apply the HCP analytic approach to data from non-HCP sources. The HCP analytic approach is surface-based for the cerebral cortex, uses the CIFTI “grayordinate” file format, provides greater statistical sensitivity than traditional volume-based analysis approaches, and allows for a more neuroanatomically-faithful representation of data. However, the HCP pipelines require the acquisition of specific images (namely T2w and field map) that historically have often not been acquired. Massive amounts of this ‘legacy’ data could benefit from the adoption of HCP-style methods. However, there is currently no published framework, to our knowledge, for adapting HCP preprocessing to “legacy” data. Here we present the ciftify project, a parsimonious analytic framework for adapting key modules from the HCP pipeline into existing structural workflows usingFreeSurfer’s recon_all structural and existing functional preprocessing workflows. Within this framework, any functional dataset with an accompanying (i.e. T1w) anatomical data can be analyzed in CIFTI format. To simplify usage for new data, the workflow has been bundled with fMRIPrep following the BIDS-app framework. Finally, we present the package and comment on future neuroinformatics advances that may accelerate the movement to a CIFTI-based grayordinate framework.HIGHLIGHTSthe ciftify package allows for grayordinate-based (CIFTI format) analysis of non-Human Connectome Project (i.e. legacy) MR acquisitionsThe workflow and dependencies are distributed as a Docker container, following the BIDS-app interfaceAdditional ciftify utilities aid in downstream analysis of CIFTI imagesWe intend for this work to offer bridging solution for legacy data that will allow many researchers to adopt CIFTI format analyses
Extensive field-sampling reveals the uniqueness of a trophy mountain goat population
Authors: Breen Jessica , Britt Meghan , Johnson Justin B. , Martchenko Daria , Shakeri Yasaman , Porter Boyd , White Kevin S. , Shafer Aaron B.A. 
Published: December 2018

ABSTRACTCollaborations between academic researchers and agencies is crucial for genetic data to have a tangible impact on conservation and wildlife management. Such partnerships are particularly important elusive species where the difficult terrain requires that a significant amount of resources and a combination of methods be used to estimate population parameters needed for conservation. We report and multi-year academic-agency collaboration on the North American mountain goat that used an extensive field sampling of genetic and phenotypic data to determine whether, and to what degree, genetic and phenotypic differences separate an isolated population of mountain goats on the Cleveland Peninsula form those in southeast Alaska. We observed significantly larger horns on the peninsula and the population appears demographically isolated. Isolation-by-distance accompanied by limited migration and low effective population size on the Cleveland Peninsula suggest this population will continue to lose genetic diversity. While the large horns of mountain goats have generated interest in re-opening mountain goat harvest on Cleveland Peninsula, our genetic data suggest this population is vulnerable to demographic and environmental perturbations and is unlikely to support a sustained harvest.
Critical-Period Visual Deprivation Disrupts Binocular Integration but Spares Spatial Acuity in the Geniculocortical Pathway
Authors: Huh Carey Y. L. , Abdelaal Karim , Salinas Kirstie J. , Gu Diyue , Zeitoun Jack , Figueroa Velez Dario X. , Peach John P. , Fowlkes Charless C. , Gandhi Sunil P. 
Published: December 2018

ABSTRACTMonocular deprivation (MD) during the juvenile critical period leads to long-lasting impairments in binocular function and visual acuity. The site of these changes has been widely considered to be cortical. However, recent evidence indicates that binocular integration may first occur in the dorsolateral geniculate nucleus of the thalamus (dLGN), raising the question of whether MD during the critical period may produce long-lasting deficits in dLGN binocular integration. Using in vivo two-photon Ca2+ imaging of dLGN afferents and excitatory neurons in superficial layers of primary visual cortex (V1), we demonstrate that critical-period MD leads to a persistent and selective loss of binocular dLGN inputs, while leaving spatial acuity in the thalamocortical pathway intact. Despite being few in number, binocular dLGN boutons display remarkably robust visual responses, on average twice stronger than monocular boutons, and their responses are exquisitely well-matched between the eyes. To our surprise, we found that MD leads to a profound binocular mismatch of response amplitude, spatial frequency and orientation tuning detected at the level of single thalamocortical synapses. In comparison, V1 neurons display deficits in both binocular integration and spatial acuity following MD. Our data provide the most compelling evidence to date demonstrating that following critical-period MD, binocular deficits observed at the level of V1 may at least in part originate from dLGN binocular dysfunction, while spatial acuity deficits arise from cortical circuits. These findings highlight a hitherto unknown role of the thalamus as a site for developmental refinement of binocular vision.
PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression
Authors: Sendinc Erdem , Valle-Garcia David , Dhall Abhinav , Chen Hao , Henriques Telmo , Sheng Wanqiang , Adelman Karen , Shi Yang 
Published: December 2018

SummarymRNA modifications play an important role in regulating gene expression. One of the most abundant mRNA modifications is N6,2-O-dimethyladenosine (m6Am). Here, we demonstrate that m6Am is an evolutionarily conserved mRNA modification mediated by the Phosphorylated CTD Interacting Factor 1 (PCIF1), which catalyzes m6A methylation on 2-O-methylated adenine located at the 5’ ends of mRNAs. Furthermore, PCIF1 catalyzes only 5’ m6Am methylation of capped mRNAs, but not internal m6A methylationin vitroandin vivo. Our global mRNA methylation analysis revealed that there is no crosstalk between m6Am and m6A mRNA methylation events, suggesting that m6Am is functionally distinct from m6A. Importantly, our data indicate that m6Am negatively impacts translation of methylated mRNAs by antagonizing cap binding protein eIF4E. Together, we identify the first and only human mRNA m6Am methyltransferase and demonstrate a novel mechanism of gene expression regulation through PCIF1-mediated m6Am mRNA methylation in eukaryotes.HighlightsPCIF1 is an evolutionarily conserved mRNA m6Am methyltransferaseLoss of PCIF1 leads to a complete loss of m6Am, whereas m6A level and distribution are not affectedPCIF1 mediated m6Am does not affect RNA Pol II transcription or mRNA stabilitym6Am-Exo-Seq is a robust methodology that enables global m6Am mappingm6Am suppresses cap dependent translation
Dynamic landscape and genetic regulation of RNA editing in schizophrenia
Authors: Breen Michael S. , Dobbyn Amanda , Li Qin , Roussos Panos , Hoffman Gabriel E. , Stahl Eli , Chess Andrew , Sklar Pamela , Li Jin Billy , Devlin Bernie , Buxbaum Joseph D. ,   for the CommonMind Consortium (CMC)
Published: December 2018

ABSTRACTRNA editing is vital for neurodevelopment and the maintenance of normal neuronal function. We surveyed the global landscape and genetic regulation of RNA editing across several hundred schizophrenia and control postmortem brain samples from the CommonMind Consortium covering two regions, the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex. In schizophrenia, RNA editing sites encoding AMPA glutamate receptors and post-synaptic density genes were less edited, while more editing was detected in sites implicated in translational initiation. These sites replicate between brain regions, map to 3’UTRs, enrich for common sequence motifs and coincide for RNA binding proteins crucial for neurodevelopment. Importantly, these findings cross-validate in hundreds of non-overlapping DLPFC samples. Furthermore, ~30% of RNA editing sites associate with cis-regulatory variants (edQTLs). Fine-mapping edQTLs with schizophrenia GWAS loci revealed colocalization of 11 edQTLs with 6 GWAS loci. This supports a causal role of RNA editing in risk for schizophrenia. Our findings illustrate widespread altered RNA editing in schizophrenia and its genetic regulation, and shed light onto RNA editing-mediated mechanisms in schizophrenia neuropathology.
Speeding up anterior-posterior patterning of insects by differential initialization of the gap gene cascade
Authors: Rudolf Heike , Zellner Christine , El-Sherif Ezzat 
Published: December 2018

AbstractRecently, it was shown that anterior-posterior patterning genes in the red flour beetleTribolium castaneumare expressed sequentially in waves. However, in the fruit flyDrosophila melanogaster, an insect with a derived mode of embryogenesis compared toTribolium, anterior-posterior patterning genes quickly and simultaneously arise as mature gene expression domains that, afterwards, undergo slight posterior-to-anterior shifts. This raises the question of how a fast and simultaneous mode of patterning, like that ofDrosophila, could have evolved from a rather slow sequential mode of patterning, like that ofTribolium. In this paper, we elucidate a mechanism for this evolutionary transition based on a switch from a uniform to a gradient-mediated initialization of the gap gene cascade by maternal Hb. The model is supported by computational analyses and experiments.
Climate and vegetation collectively drive soil respiration in montane forest-grassland landscapes of the southern Western Ghats, India
Authors: Joshi Atul Arvind , Ratnam Jayashree , Paramjyothi Harinandanan , Sankaran Mahesh 
Published: December 2018

AbstractLand-use conversion to non-native species plantations not only affects biodiversity but also alters important ecosystem functions including above- and below-ground carbon sequestration, and CO2 release rates from soils via soil respiration. Though the role of soil temperature and moisture on soil respiration is well recognized, little is known about how their effects vary across different land-use types. This study looked at the effects of land-cover change on temporal patterns of soil respiration in a montane forest-grassland-plantation matrix, a highly diverse but climatically sensitive ecosystem in the tropical Western Ghats of India. Among native vegetation types, soil respiration rates were higher in grassland compared to forest patches. Invasion of grassland by an exotic tree species - wattle (Acacia mearnsii) reduced soil respiration rates to levels similar to that of forests. However, conversion of native grasslands to non-native pine (Pinus patula) plantations led to the largest declines in soil respiration rates. In addition, the sensitivity of soil respiration to changes in temperature and moisture differed between different vegetation types. Across all vegetation types, respiration was largely insensitive to changes in soil temperature when moisture levels were low. However, when soil moisture levels were high, respiration increased with temperature in grassland and wattle patches, decreased in the case of pine plantations, and remained largely unchanged in shola forests. Our results suggest that changes in aboveground vegetation type can significantly affect soil C cycling even in the absence of any underlying differences in soil type.
Dockomo Heavy Machinery Equipment Ltd.: Spare Parts Supply Chain Management
Authors: Narayanan A , Seshadri S 
Published: December 2018

This case was developed solely for the purpose of classroom discussion. Some details of the case, including names of the companies, have been disguised. This case is not intended to serve as endorsements, sources of academic or business data, or illustrations of effective or ineffective management of the personnel or company.
Only when the custodial staff showed up at his office door did Vinod Mehra realize that it was already 3 am. Vinod is the VP of Supply Chain for Dockomo Heavy Machinery Equipment Limited. He had spent the entire night analyzing the data from the spare parts division in Pune, India. It was April 15 and he had just two weeks to go before the annual review of the company.
The spare parts division's growth at Dockomo has slowed down to about 10 percent annually when compared to the growth rate of 20 percent an nually over the previous years. Their cancelled orders stood at a staggering 8 percent due to parts unavailability, but at the same time the inventory in the system was $6 million higher than the previous year. Vinod was unsure of the response he would receive from the board of directors, since the inventory level increased along with the number of cancelled orders.
At the meeting, the board was considerate, but Vinod was asked to conduct an analysis of the shortcomings and prepare a report on the leading causes for the unavailability of parts to the customers. He was also asked to prepare a report on the approach to be followed to fix these problems by the next quarterly meeting. Vinod was already aware of many issues which existed in the supply chain, but he had to go through a complete analysis to gain a clearer understanding of the shortcomings in their distribution processes.
Model building of doctoral candidates’ innovative ability tendency test based on gray target contribution theory
Authors: Sun Caiyun , Shi Li 
Published: December 2018

Purpose
The purpose of this paper is to evaluate doctoral candidates’ innovative ability tendency.

Design/methodology/approach
This study uses the theory of gray target contribution to analyze the influence degree of doctoral candidates’ individual personality factor toward their innovative ability and calculate gray impact quantitative values.

Findings
Based on the theory of contribution degree of gray target, a nine-factor model of innovative personality of doctoral candidates is built. IP=f (B, H, G, Q1, Q2, A, I, F, O), (therein: B – intelligence, H – social boldness, G – perseverance, Q1 – experimental, Q2 – independence, A – gregariousness, I – sensibility, F – excitability, O – anxiety).

Practical implications
This study based on gray target contribution theory builds nine-factor doctoral candidates’ innovative personality model to test the innovative ability tendency of doctoral candidates, which makes cultivating units, mentors and doctoral candidates to know their innovative ability tendency well, perfecting their own knowledge structure in time, effectively improving their innovative ability. The system can also be applied to the work of doctoral candidates as a reference tool to evaluate the innovative ability of applicants.

Originality/value
This study quantitatively evaluates the influence of doctoral candidates’ personality index on the tendency of doctoral candidates’ innovative ability.
Why do internet consumers block ads? New evidence from consumer opinion mining and sentiment analysis
Authors: Tudoran Ana Alina 
Published: December 2018

PurposeThe number of internet consumers who adopt ad-blocking is increasing rapidly all over the world. The purpose of this paper is to evaluate this phenomenon by: assembling the existing considerations and key theoretical aspects of the determinants of online ad-blocking; and by exploring the consumers’ beliefs and sentiments toward online ads and expected outcomes of ad-blocking behavior.Design/methodology/approachData consist of 4,093 consumers’ opinions in response to the news items about ad-blocking, published by a leading news and technology website in the period 2010–2016. The unstructured data are analyzed using probabilistic topic modeling and sentiment analysis.FindingsFive main topics are identified, unveiling the hidden structure of consumers’ beliefs. A sentiment analysis profiling the clustered opinions reveals that the opinions that are focused on the behavioral characteristics of ads express the strongest negative sentiment, while the opinions centered on the possibility to subscribe to an ad-free fee-financed website are characterized on average by a positive sentiment.Practical implicationsThe findings provide useful insights for practitioners to create/adopt more acceptable ads that translate into less ad-blocking and improved internet surfing experience. It brings insights on the question of whether ad-free subscription websites have or do not have the potential to become a viable business opportunity.Originality/valueThe research: improves the current understanding of the determinants of ad-blocking by introducing a conceptual framework and testing it empirically; makes use of consumer-generated data on the internet; and implements novel techniques from the data mining literature.
Just being there matters
Authors: Wang Nan , Sun Yongqiang , Shen Xiao-Liang , Liu Dina , Zhang Xi 
Published: December 2018

PurposeAlthough user behaviors in social network service (SNS) have been well studied in prior literature, most of these studies focus on those behaviors with relatively deep user engagement such as information disclosure, while the underlying mechanisms that explain users’ shallow engagement behaviors (e.g. Like behavior) have been rarely discussed. To fill this research gap, the purpose of this paper is to propose and empirically test a research model to identify the antecedents of Like behavior.Design/methodology/approachThis study identifies the distinctions between post behavior and Like behavior and develops a research model of Like behavior by emphasizing the role of sense of presence from the perspective of symbolic interactionism. The model is tested through a survey with 479 users of WeChat (a popular SNS tool in China). Structural equation modeling, SmartPLS in particular, is used for data analysis.FindingsThree value perceptions, namely cognitive value, hedonic value and social value, are found to be positively associated with Like intention, and sense of presence is found to affect Like intention both directly and indirectly via the three value perceptions.Research limitations/implicationsThe research model is tested based on a specific SNS in China, so whether the conclusions can be applied to other research contexts should be further examined in future research. This study identifies the distinctions between post behavior and Like behavior and suggests to view the Like behavior from the perspective of symbolic interactionism.Practical implicationsThe paper outlines ways to effectively promote SNS users’ Like behaviors by enhancing the functions related to three value perceptions, especially by enriching the ways that facilitate interpersonal interactions.Originality/valueThis paper is one of the first to distinguish Like behavior from post behavior in SNS, propose and empirically test a research model of Like behavior. In particular, this paper strengthens the important role of sense of presence from the perspective of symbolic interactionism which has rarely been investigated in prior studies.
The mediating role of knowledge integration model for enterprise systems success
Authors: Ghazali Razatulshima , Ahmad Mohammad Nazir , Sedera Darshana , Zakaria Nor Hidayati 
Published: December 2018

PurposeThe purpose of this paper is to empirically demonstrate how knowledge management, particularly knowledge integration (KI), acts as a mediator in enterprise systems (ES) post-implementation stage and how transactional and transformational leadership styles are impacted toward ES success.Design/methodology/approachDrawing on the insights of 508 valid respondents from various business backgrounds that used ES in Malaysia, structural equation modeling was employed and the path modeling approach was used to investigate the underlying relationships between variables. The mediating effects were tested using the bootstrapping procedures presented by Preacher and Hayes.FindingsThe results support the mediating effects of KI mechanisms and both leadership styles toward ES success. The analysis revealed the importance of KI in an organization, especially by the leaders who manage the complexity of the ES in the post-implementation stage.Research limitations/implicationsThe study can be extended by analyzing other leadership styles in-detail.Practical implicationsThis paper is useful for practitioners as it acts as a guide to conduct management practice for business managers.Originality/valueThe results demonstrate the importance of leaders’ adoption of KI mechanisms in various business domains. This study approach can be used to investigate which sub-items of the leadership styles are more likely to promote KI mechanisms.