bluuebunny/crossref_metadata_2025_split huggingface dataset:
GMRT 610 MHz observations of galaxy clusters in the ACT equatorial sample
Authors: Knowles Kenda , Baker Andrew J , Bond J Richard , Gallardo Patricio A , Gupta Neeraj , Hilton Matt , Hughes John P , Intema Huib , López-Caraballo Carlos H , Moodley Kavilan , Schmitt Benjamin L , Sievers Jonathan , Sifón Cristóbal , Wollack Edward 
Published: March 2019

Abstract
We present Giant Metrewave Radio Telescope (GMRT) 610 MHz observations of 14 Atacama Cosmology Telescope (ACT) clusters, including new data for nine. The sample includes 73 per cent of ACT equatorial clusters with M500 &gt; 5 × 1014 M⊙. We detect diffuse emission in three of these (27$^{+20}_{-14}$ per cent): we detect a radio minihalo in ACT-CL J0022.2–0036 at z = 0.8, making it the highest redshift minihalo known; we detect potential radio relic emission in ACT-CL J0014.9–0057 (z = 0.533); and we confirm the presence of a radio halo in low-mass cluster ACT-CL J0256.5+0006, with flux density S610 = 6.3 ± 0.4 mJy. We also detect residual diffuse emission in ACT-CL J0045.9–0152 (z = 0.545), which we cannot conclusively classify. For systems lacking diffuse radio emission, we determine radio halo upper limits in two ways and find via survival analysis that these limits do not significantly affect radio power scaling relations. Several clusters with no diffuse emission detection are known or suspected mergers, based on archival X-ray and/or optical measures; given the limited sensitivity of our observations, deeper observations of these disturbed systems are required in order to rule out the presence of diffuse emission consistent with known scaling relations. In parallel with our diffuse emission results, we present catalogues of individual radio sources, including a few interesting extended sources. Our study represents the first step towards probing the occurrence of diffuse emission in high-redshift (z ≳ 0.5) clusters, and serves as a pilot for statistical studies of larger cluster samples with the new radio telescopes available in the pre-SKA era.
Respiratory rates observed over 15 and 30 s compared with rates measured over 60 s: practice-based evidence from an observational study of acutely ill adult medical patients during hospital admission
Authors: Rimbi M , Dunsmuir D , Ansermino J M , Nakitende I , Namujwiga T , Kellett J 
Published: March 2019

AbstractBackgroundRespiratory rate is often measured over a period shorter than 1 min and then multiplied to produce a rate per minute. There are few reports of the performance of such estimates compared with rates measured over a full minute.AimCompare performance of respiratory rates calculated from 15 and 30 s of observations with measurements over 1 min.DesignA prospective single center observational studyMethodsThe respiratory rates calculated from observations for 15 and 30 s were compared with simultaneous respiratory rates measured for a full minute on acutely ill medical patients during their admission to a resource poor hospital in sub-Saharan Africa using a novel respiratory rate tap counting software app.ResultsThere were 770 respiratory rates recorded on 321 patients while they were in the hospital. The bias (limits of agreement) between the rate derived from 15 s of observations and the full minute was −1.22 breaths per minute (bpm) (−7.16 to 4.72 bpm), and between the rate derived from 30 s and the full minute was −0.46 bpm (–3.89 to 2.97 bpm). Rates observed over 1 min that scored 3 National Early Warning Score points were not identified by half the rates derived from 15 s and a quarter of the rates derived from 30 s.ConclusionPractice-based evidence shows that abnormal respiratory rates are more reliably detected with measurements made over a full minute, and respiratory rate measurement ‘short-cuts’ often fail to identify sick patients.
Infinitesimal Automorphisms of VB-Groupoids and Algebroids
Authors: Esposito Chiara , Vitagliano Luca , Tortorella Alfonso Giuseppe 
Published: March 2019

Abstract
VB-groupoids and algebroids are vector bundle objects in the categories of Lie groupoids and Lie algebroids, respectively, and they are related via the Lie functor. VB-groupoids and algebroids play a prominent role in Poisson and related geometries. Additionally, they can be seen as models for vector bundles over singular spaces. In this paper we study their infinitesimal automorphisms, i.e. vector fields on them generating a flow by diffeomorphisms preserving both the linear and the groupoid/algebroid structures. For a special class of VB-groupoids/algebroids coming from representations of Lie groupoids/algebroids, we prove that infinitesimal automorphisms are the same as multiplicative sections of a certain derivation VB-groupoid/algebroid.
Service Use Following First-Episode Schizophrenia Among Commercially Insured Youth
Authors: Gilmer Todd P , van der Ven Els , Susser Ezra , Dixon Lisa B , Olfson Mark 
Published: March 2019

Abstract

Objective
To investigate patterns of mental health service and antipsychotic use following a first-episode schizophrenia (FES) and to examine the role of the treatment setting in which individuals are first diagnosed.

Method
Analysis of de-identified administrative claims data from the OptumLabs Data Warehouse was used to identify 1450 privately insured youth and young adults aged 14 through 30 with FES from January 1, 2011 through December 31, 2015. Regression analysis was used to estimate the use of mental health services during the year following FES, by type of service and by site of index diagnosis.

Results
In the year following FES, 79.7% of youth received outpatient mental health services and 35.8% filled a prescription for antipsychotic medication. Among service users, mean outpatient visits were 15.9 and mean antipsychotic fills were 8.3. Youth who received an index diagnosis of FES in an inpatient setting were more likely to fill an antipsychotic medication than youth with FES in other settings. Youth who received an index diagnosis of FES during a specialty mental health outpatient visit had greater use of outpatient mental health than youth who received their diagnosis during a primary care visit.

Conclusions
Despite evidence-based guidelines supporting outpatient psychosocial care and antipsychotic treatment for FES, one-fifth of this cohort did not use outpatient services and the majority did not fill any prescriptions for antipsychotic medications during the year following FES. Our findings provide renewed urgency to ongoing efforts to accelerate early identification and care coordination for youth with FES.
Tracking the Pendulum Swing on Legislative Entrenchment in New Zealand
Authors: Shiels Timothy , Geddis Andrew 
Published: March 2019

Abstract
When New Zealand’s Parliament legislates to the effect that law on some particular matter may only be enacted using a mandated procedure, can the New Zealand judiciary enforce this provision against a future Parliament that fails to comply with it? Following the Supreme Court’s recent refusal to conclusively decide this question, we examine why it still remains controversial in New Zealand. We first set the issue in a wider constitutional framework, explaining how such judicial enforcement requires considering the nature of parliamentary sovereignty and the role of the courts in defining this. The way in which the matter has been addressed over time in New Zealand and elsewhere—the pendulum swing of constitutional understandings, to use the Supreme Court’s term—is then outlined. We draw on this analysis to examine why the Supreme Court felt unable to resolve the particular question of enforceability, while also raising an as-yet unexamined question as to how such enforcement implicates the statutorily guaranteed parliamentary privilege of non-interference in the internal affairs of the House. We conclude that because it is unlikely this issue will come before the courts again in the near term, continued uncertainty over the law in this area is set to continue.
Species diversity of Marmosa subgenus Micoureus (Didelphimorphia, Didelphidae) and taxonomic evaluation of the white-bellied woolly mouse opossum, Marmosa constantiae
Authors: Lima Silva Luan Gabriel De , Ferreira Daniela Cristina , Rossi Rogério Vieira 
Published: March 2019

AbstractMarmosa subgenus Micoureus contains six currently recognized species, distributed from southern Belize to northern Argentina. Although recent studies have demonstrated the monophyly of the subgenus, the species have not been recently revised. Except for M. phaea, we evaluated the species diversity in this subgenus of mouse opossums using integrated morphological, morphometric and molecular data, with emphasis on M. constantiae. We used a total of 700 specimens for morphological and morphometric analyses. For phylogenetic, species delimitation, molecular variance and population structuring analyses (the latter two only for M. constantiae), we used the mitochondrial cytochrome b gene. Morphometric variation patterns were evaluated through Principal Component Analysis and Discriminant Function Analysis. Our results indicate that there are seven species in our samples. Among the species analysed morphologically, some can be discriminated by craniodental measurements and all can be discriminated through morphology. Marmosa constantiae is polyphyletic, composed of two lineages, one of which is correctly named M. budini. Marmosa constantiae (s.s.) has a well-known genetic structure, with no clear geographic structure and no consistent morphological patterns. Several records of M. demerarae in the literature correspond to M. constantiae. Marmosa demerarae may thus represent a complex formed of at least two species.
Pharmacodynamic Therapeutic Drug Monitoring for Cancer: Challenges, Advances, and Future Opportunities
Authors: Veal Gareth J. , Amankwatia Edward B. , Paludetto Marie-Noëlle , Möcklinghoff Till , Thomson Fiona , André Nicolas , Ciccolini Joseph , Chatelut Etienne 
Published: March 2019

Abstract:
In the modern era of cancer treatment, with targeted agents superseding more traditional cytotoxic chemotherapeutics, it is becoming increasingly important to use stratified medicine approaches to ensure that patients receive the most appropriate drugs and treatment schedules. In this context, there is significant potential for the use of pharmacodynamic biomarkers to provide pharmacological information, which could be used in a therapeutic drug monitoring setting. This review focuses on discussing some of the challenges faced to date in translating preclinical pharmacodynamic biomarker approaches to a clinical setting. Recent advances in important areas including circulating biomarkers and pharmacokinetic/pharmacodynamic modeling approaches are discussed, and selected examples of anticancer drugs where there is existing evidence to potentially advance pharmacodynamic therapeutic drug monitoring approaches to deliver more effective treatment are discussed. Although we may not yet be in a position to systematically implement therapeutic drug monitoring approaches based on pharmacodynamic information in a cancer patient setting, such approaches are likely to become more commonplace in the coming years. Based on ever-increasing levels of pharmacodynamic information being generated on newer anticancer drugs, facilitated by increasingly advanced and accessible experimental approaches available to researchers to collect these data, we can now look forward optimistically to significant advances being made in this area.
Improving Therapeutic Decisions: Pharmacodynamic Monitoring as an Integral Part of Therapeutic Drug Monitoring
Authors: Shipkova Maria , Christians Uwe 
Published: March 2019

Abstract:
Although the monitoring of drug therapies based on the determination of drug concentrations in biological materials is certainly an important instrument for individualized dosing and dose adjustment with a broad variety of pharmaceuticals, its role is limited by the fact that it does not reflect pharmacodynamic (PD) and toxicodynamic interactions such as those caused by individual and environment-related factors. However, these interactions are important for both the efficacy and the safety of the drug therapy. Therefore, during recent years, there is an increased interest in personalized drug therapy as reflected by the development and clinical implementation of molecular “biomarkers” that are direct or surrogate markers of pharmacological effects [PD therapeutic drug monitoring (TDM)]. Moreover, this process is driven by new developments in instrumentation, such as mass spectrometry and array technologies, and in computational biology/pharmacology, databases, and bioinformatics. This Focus Issue of the journal focuses on current achievements in and status of PD TDM with different classes of drugs. The contributions to the present issue of Therapeutic Drug Monitoring provide a critical analysis of current practices of TDM with their limitations, introduce newer promising biomarkers in the field of PD TDM, discuss the challenges faced to date in translating preclinical tools into clinical settings, and point out recent advances in the establishment of modeling approaches that apply to pharmacokinetics (PK)/PD as well as pharmacogenetic information.
Echocardiographic assessment of left ventricular diastolic pressure
Authors: McLean Anthony S. 
Published: March 2019

Purpose of review
Knowledge of the left ventricular pressures throughout the cardiac cycle is of considerable assistance in managing a haemodynamically unstable patient. Invasive pressure measurement is the only accurate way to analyze ventricular diastolic pressures but this is not feasible outside the catheterization laboratory, whereas the use of a pulmonary artery catheter or Doppler echocardiography, using surrogate measurements, is available at the bedside. The ever-increasing trend toward noninvasive monitoring puts echocardiography at the forefront and considerable effort has been made to define its role in this setting.

Recent findings
Ongoing refinement of guidelines used to evaluate left ventricular diastolic function have provided a pathway for critical care physicians to better understand how to evaluate left ventricular end-diastolic pressure and/or left atrial pressures. A number of recent studies have investigated the accuracy of combined or single echocardiographic parameters in determining left ventricular diastolic pressures as compared to those obtained invasively. Specifically selected combined parameters have moderate accuracy.

Summary
The recent literature on the clinical application of echocardiography on the accuracy in determining left ventricular noninvasively demonstrates that although far from perfect, it can be a very useful tool.
Nurses' Views on Using Pasteurized Donor Human Milk for Hypoglycemic Term Infants
Authors: Ferrarello Debi , Froh Elizabeth B. , Hinson Tyonne D. , Spatz Diane L. 
Published: March 2019

Abstract

Purpose:
The purpose of this study was to explore maternal child nurses' knowledge and beliefs about using pasteurized donor human milk (PDHM) to treat newborns with hypoglycemia. Pasteurized donor human milk has been used for decades in neonatal intensive care units, but its use is relatively new in the well-baby population.

Study Design and Methods:
Focus groups of maternal child nurses were conducted to explore this topic.

Results:
Six focus groups that included a total 20 nurses were held. Four themes were identified: 1) nurses presumed safety of PDHM but lacked knowledge, 2) nurses' role as patient–family advocate, 3) nurses' logistical concerns about implementation of PDHM, and 4) nurses lacked clarity on formal milk sharing versus PDHM.

Clinical Implications:
As the use of PDHM increases for well babies, nurses will need more education about PDHM, its safety profile, its use in breastfeeding support and protection of the infant microbiome, and how PDHM differs from informal milk sharing. Nurses play an important role in helping parents weigh risks and benefits of using PDHM or formula when supplementation is needed during the hospital stay. It is important that nurses feel confident in their own knowledge and ability to address parental concerns so they can advocate for their patients and support parental decision-making.
A Tablet-Based Tool for Accurate Measurement of Hand Proprioception After Stroke
Authors: Block Hannah J. , Mirdamadi Jasmine L. , Ryckman Sydney , Lynch Anna K. , Wilson Reid , Udayan Divya , Massie Crystal L. 
Published: March 2019

Background and Purpose:
Proprioceptive deficits in the hand are common following stroke, but current clinical measurement techniques are too imprecise to detect subtle impairments or small changes. We developed a tablet-based tool to measure static hand proprioception using an adaptive staircase procedure.

Methods:
In 16 individuals with chronic stroke and age-matched controls, we quantified proprioception at the metacarpophalangeal joint of the index finger using 3 methods: the tablet task, a custom passive movement direction discrimination test (PMDD), and a manual assessment similar to the Fugl-Meyer (F-M) proprioception subsection.

Results:
The tablet-based measure and the PMDD both identified impaired proprioception in the affected hand relative to the unaffected hand (P = 0.024 and 0.028), and relative to the control group (P = 0.040 and 0.032), while manual assessment did not. The PMDD had a ceiling effect as movement excursions greater than 15^ were not biomechanically feasible. The tablet-based measure and the PMDD detected impaired proprioception in 56% to 75%, and the F-M in only 29%, of patients. PMDD and tablet-based measures were both correlated with primary tactile sensation, but not manual dexterity.

Discussion and Conclusions:
Both the tablet-based tool and the custom PMDD performed better than manual assessment. The PMDD may be useful when the deficit is mild or assessment of dynamic proprioception is desired. As the tablet-based measure does not have the ceiling effect that is associated with the PMDD, it may be useful with any level of proprioceptive impairment, and may be preferable if testing or clinician training time needs to be minimized, or pain or spasticity is present.

Video Abstract available for more insights from the authors (see the Video, Supplementary Digital Content 1, available at: http://links.lww.com/JNPT/A256).
Approach to the Examination and Classification of Nystagmus
Authors: Eggers Scott D. Z. 
Published: March 2019

Background and Purpose:
Physical therapists caring for patients with neurologic or vestibular disorders must routinely examine and characterize nystagmus and other oscillatory eye movements. Often, the diagnosis hinges on proper interpretation of the nystagmus pattern. This requires understanding the terminology surrounding the numerous attributes and influencing factors of nystagmus, a systematic approach to the examination, and a classification structure that guides practitioners to the specific nystagmus type and subsequent evaluation and management.

Summary of Key Points:

Nystagmus is an involuntary, rapid, rhythmic, oscillatory eye movement with at least 1 slow phase. Jerk nystagmus has a slow phase and a fast phase. Pendular nystagmus has only slow phases. Nystagmus is distinguished from other types of oscillatory eye movements, such as saccadic intrusions or oscillations. Characterizing nystagmus requires clearly describing its trajectory. This includes choosing a reference frame to describe the axes or planes and direction of eye movements. Several attributes are used to describe nystagmus: binocularity, conjugacy, velocity, waveform, frequency, amplitude, intensity, temporal profile, and age at first appearance. Several factors may influence nystagmus, including gaze position, visual fixation, vergence, and a variety of provocative maneuvers. Classification of nystagmus may be organized by physiologic or pathologic nystagmus versus other nystagmus-like movements. Pathologic nystagmus may be spontaneous, gaze-evoked, or triggered by provocative maneuvers. The combination of attributes allows differentiation between the many peripheral and central forms.

Recommendations for Clinical Practice:
Therapists should carefully examine and characterize the trajectory and other attributes and influencing factors of nystagmus to accurately classify it and arrive at the correct diagnosis.
Update on HINTS Plus, With Discussion of Pitfalls and Pearls
Authors: Kattah Jorge C. 
Published: March 2019

Background and Purpose:
The team that manages acute vertigo in patients requires multispecialty skills. This special interest article offers a simplified list of common pitfalls to be avoided when applying the HINTS (Head-Impulse, Nystagmus, Test-of-Skew) Plus examination protocol in patients with acute vertigo. Benign paroxysmal positional vertigo is the most frequent cause of positional vertigo. The lack of systematic evaluation of symptom duration and triggers, and/or incomplete target examination, leads to improper diagnosis and management. Pitfalls to avoid and pearls to apply are offered to avoid misclassification of acute vertigo.

Summary of Key Points:
Appropriate, expeditious treatment implemented upon diagnostic certainty by the first health professional evaluating the patient is key to a good outcome. The absence of a typical positional nystagmus is particularly concerning for an alternative diagnosis. Misclassification of the type of vertigo leads to potential diagnostic error. The HINTS Plus examination is useful when applied to the correct clinical scenario. The most common misclassification of vertigo relates to an inability to detect spontaneous nystagmus suppressed by visual fixation and subsequent classification and treatment for positional vertigo. The second most common classification relates to inadequate evaluation of the HINTS Plus examination.

Recommendations for Clinical Practice:
Through an organized evaluation of the acutely vertiginous patient, common pitfalls in the classification of vertigo can be avoided. Such an evaluation leads to identification of those patients who require canal repositioning maneuvers and those who need referral for evaluation of other causes.
The Utility of the Focused Assessment With Sonography in Trauma Examination in Pediatric Blunt Abdominal Trauma
Authors: Liang Tian , Roseman Eric , Gao Melanie , Sinert Richard 
Published: March 2019

Objective
To evaluate the utility of the Point of Care Ultrasound (POCUS) Focused Assessment with Sonography for Trauma (FAST) examination for diagnosis of intra-abdominal injury (IAI) in children presenting with blunt abdominal trauma.

Methods
We searched medical literature from January 1966 to March 2018 in PubMed, EMBASE, and Web of Science. Prospective studies of POCUS FAST examinations in diagnosing IAI in pediatric trauma were included. Sensitivity, specificity, and likelihood ratios (LR) were calculated using a random-effects model (95% confidence interval). Study quality and bias risk were assessed, and test-treatment threshold estimates were performed.

Results
Eight prospective studies were included encompassing 2135 patients with a weighted prevalence of IAI of 13.5%. Studies had variable quality, with most at risk for partial and differential verification bias. The results from POCUS FAST examinations for IAI showed a pooled sensitivity of 35%, specificity of 96%, LR+ of 10.84, and LR− of 0.64. A positive POCUS FAST posttest probability for IAI (63%) exceeds the upper limit (57%) of our test-treatment threshold model for computed tomography of the abdomen with contrast. A negative POCUS FAST posttest probability for IAI (9%) does not cross the lower limit (0.23%) of our test-treatment threshold model.

Conclusions
In a hemodynamically stable child presenting with blunt abdominal trauma, a positive POCUS FAST examination result means that IAI is likely, but a negative examination result alone cannot preclude further diagnostic workup for IAI. The need for computed tomography scan may be obviated in a subset of low-risk pediatric blunt abdominal trauma patients presenting with a Glasgow Coma Scale of 14 to 15, a normal abdominal examination result, and a negative POCUS FAST result.