bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lanthanide phosphate (LnPO4) rods as bio‐probes: A systematic investigation on structural, optical, magnetic, and biological characteristics
Authors: Meenambal Rugmani , Poojar Pavan , Geethanath Sairam , Anitha T. S. , Kannan S. 
Published: September 2018

AbstractThe proposed work involves an exclusive study on the synthesis protocol, crystal structure analysis, and imaging contrast features of unique lanthanide phosphates (LnPO4). XRD and Raman spectra affirmed the ability of the proposed synthesis technique to achieve unique LnPO4 devoid of impurities. The crystal structure analysis confirms the P121/c1 space setting of NdPO4, EuPO4, GdPO4, and TbPO4 that all uniformly crystallizes in monoclinic unit cell. In a similar manner, the tetragonal crystal setting of DyPO4, ErPO4, HoPO4, and YbPO4 that unvaryingly possess the I41/amd space setting is confirmed. Under the same synthesis conditions, the monoclinic (Eu) and tetragonal (Ho) lanthanide phosphates displayed uniform rod‐like morphologies. Absorption and luminescence properties of unique LnPO4 were determined. In vitro biological studies demonstrated low toxicity levels of LnPO4 and clearly distinguished fluorescence of TbPO4 and EuPO4 in Y79, retinoblastoma cell lines. The paramagnetic response of GdPO4, NdPO4, DyPO4, TbPO4, and HoPO4 facilitated excellent magnetic resonance imaging (MRI) contrast features. Meanwhile, GdPO4, DyPO4, HoPO4, and YbPO4 possessing higher X‐ray absorption coefficient than clinical contrast Omnipaque™ exhibited high computed tomography (CT) efficiency. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1372–1383, 2019.
Bone regeneration by calcium phosphate‐loaded carboxymethyl cellulose nonwoven sheets in canine femoral condyle defects
Authors: Sakamoto Ayumi , Qi Pan , Ohba Shinsuke , Ohta Seiichi , Hara Yuichi , Ogawa Takayuki , Tomokiyo Masahiro , Sasaki Akari , Takizawa Harue , Mochizuki Manabu , Ito Taichi , Honnami Muneki 
Published: September 2018

AbstractThe bone regeneration capacities of calcium phosphate (CaP)‐loaded carboxymethyl cellulose (CMC) nonwoven sheet (CMC/CaP) were evaluated using a dog lateral femoral condyle defect model. In addition, the effect of bFGF on bone regeneration when added to CMC/CaP sheet was investigated. The CMC and CMC/CaP sheets have high operability. The new bone formation rate in the CMC/CaP group was significantly higher than that in the control and CMC groups based on micro‐computed tomography and histological evaluation. In contrast, there was no significant difference between the CMC/CaP group and the CMC/CaP/f group. In conclusion, the CMC/CaP sheet has the ability to promote new bone formation and seems to be useful as a sheet‐shaped bone graft substitute. The effect of the auditioning signaling molecules to the CMC/CaP sheet, such as bFGF, requires further investigation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1516–1521, 2019.
Endothelial repair is dependent on CD11c+ leukocytes to establish regrowing endothelial sheets with high cellular density
Authors: Yrlid Ulf , Holm Maricris , Levin Malin , Alsén Samuel , Lindbom Malin , Glise Lars , Bergh Niklas , Borén Jan , Fogelstrand Per 
Published: September 2018

Abstract
Endothelial injury makes the vessel wall vulnerable to cardiovascular diseases. Injured endothelium regenerates by collective sheet migration, that is, the endothelial cells coordinate their motion and regrow as a sheet of cells with retained cell-cell contacts into the wounded area. Leukocytes appear to be involved in endothelial repair in vivo; however, little is known about their identity and role in the reparative sheet migration process. To address these questions, we developed a high-quality en face technique that enables visualizing of leukocytes and endothelial cells simultaneously following an endoluminal scratch wound injury of the mouse carotid artery. We discovered that regrowing endothelium forms a broad proliferative front accompanied by CD11c+ leukocytes. Functionally, the leukocytes were dispensable for the initial migratory response of the regrowing endothelial sheet, but critical for the subsequent formation and maintenance of a front zone with high cellular density. Marker expression analyses, genetic fate mapping, phagocyte targeting experiments, and mouse knock-out experiments indicate that the CD11c+ leukocytes were mononuclear phagocytes with an origin from both Ly6Chigh and Ly6Clow monocytes. In conclusion, CD11c+ mononuclear phagocytes are essential for a proper endothelial regrowth following arterial endoluminal scratch injury. Promoting the endothelial-preserving function of CD11c+ leukocytes may be a strategy to enhance endothelial repair following surgical and endovascular procedures.
CD11c+ mononuclear phagocytes are recruited specifically to regenerating endothelium following vascular injury to orchestrate endothelial sheet migration.
Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair
Authors: Walia Bhavita , Huang Alice H. 
Published: October 2018

ABSTRACTTendon and ligament injuries are a leading cause of healthcare visits with significant impact in terms of economic cost and reduced quality of life. To date, reparative strategies remain largely restricted to conservative treatment or surgical repair. However, these therapies fail to restore native tendon structure and function; thus, the tissue may re‐rupture or degenerate with time. To improve tendon healing, one promising strategy may be harnessing the innate potential of resident tendon stem/progenitor cells (TSPCs) to guide tenogenic regeneration. In this review, we outline recent advances in the identification and characterization of putative TSPC populations, and discuss biochemical, biomechanical, and biomaterial methods employed for their culture and differentiation. Finally, we identify limitations in our current understanding of TSPC biology, key challenges for their use, and potential therapeutic strategies to inform cell‐based tendon repair. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1270–1280, 2019.
Sensitive, simple and rapid colorimetric detection of malachite green in water, salmon and canned tuna samples based on gold nanoparticles
Authors: Heleyel Mina , Elhami Shahla 
Published: September 2018

AbstractBACKGROUNDMalachite green is used in aquaculture and fisheries as a fungicide and antiseptic and it is also used in industry as a dye. However, malachite green is carcinogenic and highly toxic for humans and animals. In this study, a spectrophotometric method was developed to detect malachite green. The method was based on the surface plasmon resonance property of gold nanoparticles and interaction between malachite green and gold nanoparticles.RESULTSMalachite green–gold nanoparticles were rapidly aggregated in the acidic medium; as a result, a color change from red to blue was observed, which was easily detectable by the naked eye. The absorption ratio (A623/A520) of the gold nanoparticles in an optimized system exhibited a linear correlation with malachite green concentration. The method detection limit and linear range were 3 and 50–350 ng mL−1, respectively. The method was applied successfully to detect malachite green in different samples.CONCLUSIONThe method was simple and rapid to detect malachite green. The most important advantages of the method are the possibility of malachite green determination with very good accuracy and sensitivity using a simple UV–visible spectrometer without any expensive or sophisticated instrumentation and also the versatility of real samples. © 2018 Society of Chemical Industry
From ancient to old and modern durum wheat varieties: interaction among cultivar traits, management, and technological quality
Authors: Mefleh Marina , Conte Paola , Fadda Costantino , Giunta Francesco , Piga Antonio , Hassoun Georges , Motzo Rosella 
Published: September 2018

AbstractFollowing the boom in durum wheat breeding, ancient wheat disappeared from the human diet and old durum wheat varieties were replaced by what is believed to be their better versions: higher yielding modern varieties grown in high‐input systems. Breeders have worked intensely ever since to improve the quality of durum wheat traits – mainly gluten subunit alleles – to obtain superior technological quality in the main durum wheat end products (first pasta and then bread) but conflicts about predicting their quality still exist. This is because quality is neither governed by one trait alone nor conditioned by a single controllable factor. This review discusses the evolution of wheat varieties from ancient to old, and then modern durum wheat in terms of agronomy, genetics, technological, and end‐product qualities. Environmental effects will not be discussed. Moving from ancient to modern durum wheat varieties, grain yield increased, grain protein concentration decreased, and gluten strength and dough toughness improved, ameliorating the quality of pasta but decreasing the durum wheat versatility. © 2018 Society of Chemical Industry
Analysis of volatile profiles of green Hawai'ian coffee beans damaged by the coffee berry borer (Hypothenemus hampei)
Authors: Walker Hannah E , Lehman Katherine A , Wall Marisa M , Siderhurst Matthew S 
Published: October 2018

AbstractBACKGROUNDThe coffee berry borer (CBB), Hypothenemus hampei, is the most destructive insect pest of coffee globally, causing significant losses in yield and leading to ‘off’ flavors in damaged beans. Automated headspace sampling (AHS) and gas chromatography–mass spectrometry (GC–MS) were used to investigate changes in the volatile profiles of CBB‐damaged green coffee beans. Green coffee from three coffee farms on the island of Hawai'i were sorted into three levels of CBB damage: non‐damaged, slightly damaged (1–2 pinholes/bean), and heavily damaged (> 2 pinholes/bean).RESULTSDistinct differences were found between green coffee bean samples based on the amounts of eight prominent volatiles. The amount of CBB damage was particularly correlated with the amount of both hexanal and 2‐pentylfuran. Principal component analysis showed clustering of non‐damaged green beans, which did not overlap with the slightly or heavily damaged clusters. Good separation was also found between a mixture of 50% slightly damaged and non‐damaged coffee. However, 20% slightly damaged and non‐damaged coffee clusters showed strong overlap.CONCLUSIONUnderstanding the effects of CBB damage on coffee flavor profiles is critical to quality control for this valuable agricultural product. The results of this study show that the volatile profiles of green coffee beans vary with CBB damage. With specific volatile profiles for CBB‐damaged coffee identified, coffee samples can be tested in the lab, or potentially on the farm or in coffee mills, to identify high levels of CBB damage that may lead to off flavors and a reduction in product quality and value. © 2018 Society of Chemical Industry
Resolution of methoxyphenamine and its analogues on a chiral stationary phase based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid
Authors: Jeon Heeyoung , Hyun Myung Ho 
Published: September 2018

AbstractA liquid chromatographic chiral stationary phase, which contains two N–CH3 amide connecting groups, based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid was first applied to the resolution of methoxyphenamine (2‐methoxy‐N‐methylamphetamine, a β‐adrenergic receptor agonist used as a bronchodilator). The resolution of methoxyphenamine on the chiral stationary phase containing two N–CH3 amide connecting groups was quite successful with the separation factor (α) of 1.42 and resolution (RS) of 4.22 compared with those (α of 1.09 and RS of 1.55) on the chiral stationary phase containing two N–H amide connecting groups. In addition, the chiral stationary phase containing two N–CH3 amide connecting groups was applied to the resolution of methoxyphenamine analogues. From the comparison of the resolution results of methoxyphenamine with those of methoxyphenamine analogues on the chiral stationary phase containing two N–CH3 amide connecting groups, the N‐methyl group and the 2‐methoxyphenyl group of methoxyphenamine were elucidated to be the structurally essential parts for the resolution on the chiral stationary phase.
On the sensitivity of quantitative susceptibility mapping for measuring trabecular bone density
Authors: Diefenbach Maximilian N. , Meineke Jakob , Ruschke Stefan , Baum Thomas , Gersing Alexandra , Karampinos Dimitrios C. 
Published: September 2018

PurposeTo develop a methodological framework to simultaneously measure and magnetic susceptibility in trabecularized yellow bone marrow and to investigate the sensitivity of Quantitative Susceptibility Mapping (QSM) for measuring trabecular bone density using a non‐UTE multi‐gradient echo sequence.MethodsThe ankle of 16 healthy volunteers and two patients was scanned using a time‐interleaved multi‐gradient‐echo (TIMGRE) sequence. After field mapping based on water–fat separation methods and background field removal based on the Laplacian boundary value method, three different QSM dipole inversion schemes were implemented. Mean susceptibility values in regions of different trabecular bone density in the calcaneus were compared to the corresponding values in the maps, bone volume to total volume ratios (BV/TV) estimated from high resolution imaging (in 14 subjects), and CT attenuation (in two subjects). In addition, numerical simulations were performed in a simplified trabecular bone model of randomly positioned spherical bone inclusions to verify and compare the scaling of and susceptibility with BV/TV.ResultsDifferences in calcaneus trabecularization were well depicted in susceptibility maps, in good agreement with high‐resolution MR and CT images. Simulations and in vivo scans showed a linear relationship of measured susceptibility with BV/TV and . The ankle in vivo results showed a strong linear correlation between susceptibility and (R2 = 0.88, p < 0.001) with a slope and intercept of −0.004 and 0.2 ppm, respectively.ConclusionsA method for multi‐paramteric mapping, including ‐mapping and QSM was developed for measuring trabecularized yellow bone marrow, showing good sensitivity of QSM for measuring trabecular bone density.
The molecular details of cytokine signaling via the JAK/STAT pathway
Authors: Morris Rhiannon , Kershaw Nadia J. , Babon Jeffrey J. 
Published: September 2018

AbstractMore than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis, induce inflammation and control the immune response. Cytokines are secreted glycoproteins that act as intercellular messengers, inducing proliferation, differentiation, growth, or apoptosis of their target cells. They act by binding to specific receptors on the surface of target cells and switching on a phosphotyrosine‐based intracellular signaling cascade initiated by kinases then propagated and effected by SH2 domain‐containing transcription factors. As cytokine signaling is proliferative and often inflammatory, it is tightly regulated in terms of both amplitude and duration. Here we review molecular details of the cytokine‐induced signaling cascade and describe the architectures of the proteins involved, including the receptors, kinases, and transcription factors that initiate and propagate signaling and the regulatory proteins that control it.
#BlackGirlMagic: The identity conceptualization of Black women in undergraduate STEM education
Authors: Morton Terrell R. , Parsons Eileen C. 
Published: September 2018

AbstractMuch of the research in science education that explores the influence of a racial and gendered identity on science, technology, engineering, and mathematics (STEM) engagement for Black women situate their identities primarily as responses to the oppression and struggles they face in STEM. In this study, we use Phenomenological Variant Ecological Systems Theory as a strengths‐based approach to investigate 10 undergraduate Black women’s perceptions of race and gender on their STEM identity development and engagement. The qualitative analysis of interview and journal data revealed these women enter STEM experiences cognizant of their race and gender identities, naming them in isolation and intersectionally as a potential risk or as being protective, positive, and empowering for their STEM engagement. These findings illuminate the importance of Black women self‐authoring their identities in STEM contexts, both in naming what is salient and defining what those names mean, and have implications for STEM retention and matriculation efforts.
miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution
Authors: Lu Yang , Cao Jin , Napoli Marco , Xia Zheng , Zhao Na , Creighton Chad J. , Li Wei , Chen Xi , Flores Elsa R. , McManus Michael T. , Rosen Jeffrey M. 
Published: September 2018

Abstract
Mammary gland development is fueled by stem cell self-renewal and differentiation. External cues from the microenvironment coupled with internal cues such as post-transcriptional regulation exerted by microRNAs regulate stem cell behavior and fate. Here, we have identified a miR-205 regulatory network required for mammary gland ductal development and stem cell regeneration following transplantation into the cleared mammary fat pad. In the postnatal mammary gland, miR-205 is predominantly expressed in the basal/stem cell enriched population. Conditional deletion of miR-205 in mammary epithelial cells impairs stem cell self-renewal and mammary regenerative potential in the in vitro mammosphere formation assay and in vivo mammary reconstitution. miR-205 null transplants display significant changes in basal cells, basement membrane, and stroma. NKD1 and PTPA, which inhibit the Wnt signaling pathway, and AMOT, which causes YAP cytoplasmic retention and inactivation were identified as miR-205 downstream mediators. These studies also confirmed that miR-205 is a direct ΔNp63 target gene that is critical for the regulation of basal cell identity.
Teaching Empathy: Exploring Multiple Perspectives to Address Islamophobia Through Children's Literature
Authors: Newstreet Carmen , Sarker Amie , Shearer Ragina 
Published: October 2018

AbstractChildren's literature text sets can be powerful tools for teaching students about diversity and literacy, engaging students in authentic purposes for literacy practices while exploring complex issues such as Islamophobia. The authors discuss how an intermediate public school teacher integrated a children's literature text set project exploring Muslim characters and communities to foster students' critical thinking, deepen their comprehension, and develop their empathy. Discussion of the texts and multimodal responses inspired students to engage in further inquiry, reflect on stereotypes, and implement a social action project: a pen pal exchange with students in Bangladesh, a Muslim country. This unit provided a safe space for students to explore a complex issue while developing critical literacy skills. As students better understand and learn to empathize with diverse others through text, they realize that people share more similarities than differences, decreasing the potential for Islamophobia in classrooms and society.
Follicular development of canine ovaries stimulated by a combination treatment of eCG and hCG
Authors: Hirata Maki , Tanihara Fuminori , Taniguchi Masayasu , Takagi Mitsuhiro , Terazono Tsukasa , Otoi Takeshige 
Published: October 2018

AbstractOvarian follicular dynamics is not well known in dogs. Imaging of ovaries is technically difficult; however, ovaries clamped at a subcutaneous site can more easily be monitored using ultrasound imaging. This study investigated the follicular development of canine ovaries stimulated by hormone treatment using ultrasound imaging of the ovaries clamped at a subcutaneous site. Oestrus was induced using subcutaneous administration of 500 IU equine chorionic gonadotropin (eCG) and 1000 IU human chorionic gonadotropin (hCG) (eCG/hCG). Five bitches were given 1000 IU hCG 11 days after eCG/hCG administration. Examinations with ovarian ultrasonography using a 7.5‐MHz sector transducer, vaginal cytology, and assays of serum oestrogen and progesterone were performed daily until 20 days after eCG/hCG administration. Serosanguineous vaginal discharges and vaginal cytology of two of the bitches were observed. New follicular growth (>1.0 mm in diameter) was observed in all bitches from 2 to 8 days after eCG/hCG administration. The mean diameter of follicles and maximum numbers of follicles per ovary ranged from 2.8 to 5.5 mm and 4 to 16, respectively. The elevation in oestrogen concentrations after eCG/hCG administration was observed in all bitches, and elevation in progesterone concentration (>2 ng mL−1) was observed in three bitches. However, no follicles ovulated until 9 days after hCG administration. In conclusion, although the number of examined bitches were limited, follicular growth in ovaries clamped at a subcutaneous site can be monitored using ultrasound imaging. Ovarian ultrasonography showed that eCG/hCG administration induced new follicular growth and hCG administration induced increases in oestrogen concentrations but not ovulation by hCG administration.
Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions
Authors: Duggal Niharika A. 
Published: September 2018

AbstractIt is widely accepted that ageing is accompanied by remodelling of the immune system, including reduced numbers of naïve T cells, increased senescent or exhausted T cells, compromise to monocyte, neutrophil and natural killer cell function and an increase in systemic inflammation. In combination these changes result in increased risk of infection, reduced immune memory, reduced immune tolerance and immune surveillance, with significant impacts upon health in old age. More recently it has become clear that the rate of decline in the immune system is malleable and can be influenced by environmental factors such as physical activity as well as pharmacological interventions. This review discusses briefly our current understanding of immunesenescence and then focuses on lifestyle interventions and therapeutic strategies that have been shown to restore immune functioning in aged individuals.
Deducing false propositions from true ideas: Nieuwentijt on mathematical reasoning
Authors: Pauw Sylvia 
Published: September 2018

AbstractThis paper argues that, for Bernard Nieuwentijt (1654–1718), mathematical reasoning on the basis of ideas is not the same as logical reasoning on the basis of propositions. Noting that the two types of reasoning differ helps make sense of a peculiar-sounding claim Nieuwentijt makes, namely that it is possible to mathematically deduce false propositions from true abstracted ideas. I propose to interpret Nieuwentijt’s abstracted ideas as incomplete mental copies of existing objects. I argue that, according to Nieuwentijt, a proposition is mathematically deducible from an abstracted idea if it can be demonstrated that that proposition makes a true claim about the object that idea forms. This allows me to explain why Nieuwentijt deems it possible to deduce false propositions from true ideas. It also implies that logic and mathematics are not as closely related for Nieuwentijt as has been suggested in the existing secondary literature.