bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of optimised trajectories on air traffic flow management
Authors: Rosenow J. , Fricke H. , Luchkova T. , Schultz M. 
Published: March 2019

ABSTRACTMulticriteria trajectory optimisation is expected to increase aviation safety, efficiency and environmental compatibility, although neither the theoretical calculation of such optimised trajectories nor their implementation into today’s already safe and efficient air traffic flow management reaches a satisfying level of fidelity. The calibration of the underlying objective functions leading to the virtually best available solution is complicated and hard to identify, since the participating stakeholders are very competitive. Furthermore, operational uncertainties hamper the robust identification of an optimised trajectory. These uncertainties may arise from severe weather conditions or operational changes in the airport management. In this study, the impact of multicriteria optimised free route trajectories on the air traffic flow management is analysed and compared with a validated reference scenario which consists of real flown trajectories during a peak hour of Europe’s complete air traffic in the upper airspace. Therefore, the TOolchain for Multicriteria Aircraft Trajectory Optimisation (TOMATO) is used for both the multicriteria optimisation of txrajectories and the calculation of the reference scenario. First, this paper gives evidence for the validity of the simulation environment TOMATO, by comparison of the integrated reference results with those of the commercial fast-time air traffic optimiser (AirTOp). Second, TOMATO is used for the multicriteria trajectory optimisation, the assessment of the trajectories and the calculation of their integrated impact on the air traffic flow management, which in turn is compared with the reference scenario. Thereby, significant differences between the reference scenario and the optimised scenario can be identified, especially considering the taskload due to frequent altitude changes and rescinded constraints given by waypoints in the reference scenario. The latter and the strong impact of wind direction and wind speed cause wide differences in the patterns of the lateral trajectories in the airspace with significant influence on the airspace capacity and controller’s taskload. With this study, the possibility of a successful 4D free route implementation into Europe’s upper airspace is proven even over central Europe during peak hours, when capacity constraints are already reaching their limits.
Do environmental preferences in wealthy nations persist in times of crisis? The European environmental attitudes (2008-2017)
Authors: Benedetta Cotta , Vincenzo Memoli 
Published: March 2019

AbstractHow do economic recessions affect European citizens’ attitudes towards environmental policies? In this article we investigate the attitudes of European citizens towards environmental protection considering its importance both at individual and country levels and adopting a longitudinal view. In light of the existing research on the link between pro-environmental attitudes and economic affluence of societies, including Ronald Inglehart’s theory of post-materialism, we hypothesise that levels of economic well-being as well as trust in political institutions are important drivers of Europeans’ attitudes towards environmental protection. Taking into consideration some macroeconomic indicators and the environmental attitude of public opinion, our main results show that even in time of crises, citizens’ pro-environmental attitudes persist in terms of importance, both at country and individual levels.
ON A QUESTION OF KRAJEWSKI’S
Authors: PAKHOMOV FEDOR , VISSER ALBERT 
Published: March 2019

AbstractIn this paper, we study finitely axiomatizable conservative extensions of a theoryUin the case whereUis recursively enumerable and not finitely axiomatizable. Stanisław Krajewski posed the question whether there are minimal conservative extensions of this sort. We answer this question negatively.Consider a finite expansion of the signature ofUthat contains at least one predicate symbol of arity ≥ 2. We show that, for any finite extensionαofUin the expanded language that is conservative overU, there is a conservative extensionβofUin the expanded language, such that$\alpha \vdash \beta$and$\beta \not \vdash \alpha$. The result is preserved when we consider eitherextensionsormodel-conservative extensionsofUinstead ofconservative extensions. Moreover, the result is preserved when we replace$\dashv$as ordering on the finitely axiomatized extensions in the expanded language by a relevant kind of interpretability, to witinterpretability that identically translates the symbols of the U-language.We show that the result fails when we consider an expansion with only unary predicate symbols for conservative extensions ofUordered by interpretability that preserves the symbols ofU.
Decreased percentage of CD4+ lymphocytes expressing chemokine receptors in bipolar disorder
Authors: Barbosa Izabela G. , Rocha Natalia P. , Vieira Erica L. , Camkurt Mehmet A. , Huguet Rodrigo B. , Guimarães Fabio T. L. , de Brito-Melo Gustavo E. , Mendonça Vanessa A. , Bauer Moises E. , Teixeira Antonio L. 
Published: March 2019

AbstractObjective:Although accumulating evidence supports the hypothesis that immune/inflammatory mechanisms are associated with the pathophysiology of bipolar disorder (BD), data about the profile of chemokines (chemotactic cytokines) and chemokine receptors are still scarce. The current study was designed to evaluate the expression of chemokine receptors on lymphocytes of patients with BD in comparison with controls.Methods:Thirty-three patients with type I BD (N= 21 in euthymia;N= 6 in mania/hypomania;N= 6 in depression) and 22 age- and sex-matched controls were subjected to clinical evaluation and peripheral blood draw. The expression of chemokine receptors CCR3, CCR5, CXCR4, and CXCR3 on CD4+and CD8+lymphocytes was assessed by flow cytometry.Results:Patients with BD had decreased percentage of CD4+CXCR3+(p= 0.024), CD4+CCR3+(p= 0.042), and CD4+CCR5+(0.013) lymphocytes in comparison with controls. The percentage of both CD4+and CD8+lymphocytes expressing the chemokine receptor CXCR4 was similar in patients with BD and controls. Likewise, the percentages of CD8+CXCR3+, CD8+CCR3+, and CD8+CCR5+lymphocytes were similar in patients with BD and controls.Conclusion:Our findings reinforce the hypothesis that immune pathways, especially involving CD4+lymphocytes, are involved in the physiopathology of BD.
The Effect of Aerobic Exercise on White Matter Hyperintensity Progression May Vary by Sex
Authors: Dao Elizabeth , Barha Cindy K. , Best John R. , Hsiung Ging-Yuek , Tam Roger , Liu-Ambrose Teresa 
Published: March 2019

RÉSUMÉCette étude a exploré l’efficacité de l’entraînement aérobie (EA) pour atténuer la progression de l’hyperintensité de la matière blanche (HMB) et les différences liées au sexe pour cette intervention. Un essai contrôlé randomisé a été mené pour évaluer l’effet de l’EA sur la cognition de personnes ayant un déficit cognitif d’origine vasculaire. Les participants ont été répartis aléatoirement entre deux groupes : 6 mois d’EA ou soins standards (groupe contrôle). Dans un sous-groupe de participants, l’imagerie par résonance magnétique a été utilisée pour quantifier le volume affecté par la HMB. Un modèle d’analyse de la covariance a permis de mettre en évidence une interaction sexe x groupe significative (p = 0,03). En effet, les femmes du groupe EA ont démontré une plus grande progression de l’hyperintensité de la matière blanche que les femmes du groupe contrôle (p = 0,05) pendant la durée de cette étude (6 mois). Chez les hommes, aucune différence n’a été observée entre les deux groupes (p = 0,31). Dans le groupe EA, les hommes ont montré une progression significativement moindre de la HMB, comparativement aux femmes (p = 0,01) après 6 mois. Ainsi, les effets de l’EA sur la progression de la HMB pourraient varier selon le sexe, et l’EA pourrait freiner la progression de la HMB chez les hommes, mais non chez les femmes.
Translating the BDI and BDI-II into the HAMD and vice versa with equipercentile linking
Authors: Furukawa Toshi A. , Reijnders Mirjam , Kishimoto Sanae , Sakata Masatsugu , DeRubeis Robert J. , Dimidjian Sona , Dozois David J.A. , Hegerl Ulrich , Hollon Steven D. , Jarrett Robin B. , Lespérance François , Segal Zindel V. , Mohr David C. , Simons Anne D. , Quilty Lena C. , Reynolds Charles F. , Gentili Claudio , Leucht Stefan , Engel Rolf R. , Cuijpers Pim 
Published: March 2019

AbstractAimsThe Hamilton Depression Rating Scale (HAMD) and the Beck Depression Inventory (BDI) are the most frequently used observer-rated and self-report scales of depression, respectively. It is important to know what a given total score or a change score from baseline on one scale means in relation to the other scale.MethodsWe obtained individual participant data from the randomised controlled trials of psychological and pharmacological treatments for major depressive disorders. We then identified corresponding scores of the HAMD and the BDI (369 patients from seven trials) or the BDI-II (683 patients from another seven trials) using the equipercentile linking method.ResultsThe HAMD total scores of 10, 20 and 30 corresponded approximately with the BDI scores of 10, 27 and 42 or with the BDI-II scores of 13, 32 and 50. The HAMD change scores of −20 and −10 with the BDI of −29 and −15 and with the BDI-II of −35 and −16.ConclusionsThe results can help clinicians interpret the HAMD or BDI scores of their patients in a more versatile manner and also help clinicians and researchers evaluate such scores reported in the literature or the database, when scores on only one of these scales are provided. We present a conversion table for future research.
Survey of glyphosate-, atrazine- and lactofen-resistance mechanisms in Ohio waterhemp (Amaranthus tuberculatus) populations
Authors: Murphy Brent P. , Larran Alvaro S. , Ackley Bruce , Loux Mark M. , Tranel Patrick J. 
Published: March 2019

AbstractHerbicide resistance within key driver weeds, such as common waterhemp [Amaranthus tuberculatus (Moq.) Sauer var. rudis (Sauer) Costea and Tardif ], constrains available management options for crop production. Routine surveillance for herbicide resistance provides a mechanism to monitor the development and spread of resistant populations over time. Furthermore, the identification and quantification of resistance mechanisms at the population level can provide information that helps growers develop effective management plans. Populations of Amaranthus spp., including A. tuberculatus, redroot pigweed (Amaranthus retroflexus L.), and Palmer amaranth (Amaranthus palmeri S. Watson), were collected from 51 fields in Ohio during the 2016 growing season. Twenty-four A. tuberculatus populations were screened for resistance to the herbicides lactofen, atrazine, and glyphosate. Phenotypically resistant plants were further investigated to determine the frequency of known resistance mechanisms. Resistance to lactofen was infrequently observed throughout the populations, with 8 of 22 populations exhibiting resistant plants. Within those eight resistant populations, the ΔG210 resistance mechanism was observed in 17 of 30 phenotypically resistant plants, and the remainder lacked all known resistance mechanisms. Resistance to atrazine was observed in 12 of 15 populations; however, a target-site resistance mechanism was not observed in these populations. Resistance to glyphosate was observed in all populations. Gene amplification was the predominant glyphosate-resistance mechanism (147 of 322 plants) in the evaluated populations. The Pro-106-Ser mutation was identified in 24 plants, half of which also possessed gene amplification. In this study, molecular screening generally underestimated the phenotypically observed resistance. Continued mechanism discovery and marker development is required for improved detection of herbicide resistance through molecular assays.
Moho Depths of Antarctica: Comparison of Seismic, Gravity, and Isostatic Results
Authors: Pappa F. , Ebbing J. , Ferraccioli F. 
Published: March 2019

AbstractThe lithospheric structure of Antarctica is still underexplored. Moho depth estimate studies are in disagreement by more than 10 km in several regions, including, for example, the hinterland of the Transantarctic Mountains. Taking account the sparseness of seismological stations and the nonuniqueness of potential field methods, inversions of Moho depth are performed here based on satellite gravity data in combination with currently available seismically constrained Moho depth estimates. Our results confirm that a lower density contrast at the Moho is present under East Antarctica than beneath West Antarctica. A comparison between the Moho depth derived from our inversion and an Airy‐isostatic Moho model also reveals a spatially variable buoyancy contribution from the lithospheric mantle beneath contrasting sectors of East Antarctica. Finally, to test the plausibility of different Moho depths scenarios for the Transantarctic Mountains‐Wilkes Subglacial Basin system, we present 2‐D lithospheric models along the Trans‐Antarctic Mountain Seismic Experiment/Gamburtsev Mountain Seismic experiment seismic profile. Our models show that if a moderately depleted lithospheric mantle of inferred Proterozoic age underlies the region, then a shallower Moho is more likely beneath the Wilkes Subglacial Basin. If however, refertilization processes occurred in the upper mantle, for example, in response to Ross‐age subduction, then a deeper Moho scenario is preferred. We conclude that 3‐D lithospheric modeling, coupled with the availability of new seismic information in the hinterland of the Transantarctic Mountains, is required to help resolve this controversy, thereby also reducing the ambiguities in geothermal heat flux estimation beneath this key part of the East Antarctic Ice Sheet.
CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4
Authors: Qi Mei , Hu Jing , Cui Yanyi , Jiao Meng , Feng Tingting , Li Xinjun , Pang Yu , Chen Xinyi , Qin Ruixi , Su Peng , Zhang Hui , Wang Yan , Gong Yaoqin , Han Bo 
Published: March 2019

AbstractHow to distinguish indolent from aggressive disease remains a great challenge in prostate cancer (PCa) management. Cullin 4B (CUL4B) is a scaffold protein and exhibits oncogenic activity in a variety of human malignancies. In this study, we utilized PCa tissue specimens, cell lines and xenograft models to determine whether CUL4B contributes to PCa progression and metastasis. Here, we show that CUL4B expression highly correlates with the aggressiveness of PCa. CUL4B expression promotes proliferation, epithelial−mesenchymal transition, and metastatic potential of PCa cells, whereas CUL4B knockdown inhibits. Mechanically, CUL4B positively regulates SOX4, a key regulator in PCa, through epigenetic silencing of miR-204. In turn, SOX4 upregulates CUL4B expression through transcriptional activation, thereby fulfilling a positive feedback loop. Clinically, CUL4B+/SOX4+ defines a subset of PCa patients with poor prognosis. Bioinformatics analysis further reveals that Wnt/ß-catenin activation signature is enriched in CUL4B+/SOX4+ patient subgroup. Intriguingly, Wnt inhibitors significantly attenuates oncogenic capacities of CUL4B in vitro and in vivo. Together, our study identifies CUL4B as a key modulator of aggressive PCa by a positive feedback loop that interacts with SOX4. This regulatory circuit may have a crucial role in PCa progression.
PEST-containing nuclear protein regulates cell proliferation, migration, and invasion in lung adenocarcinoma
Authors: Wang Da-Yong , Hong Ya , Chen Ya-Ge , Dong Peng-Zhen , Liu Shi-Yu , Gao Ying-Ran , Lu Dan , Li Hui-Min , Li Tao , Guo Jian-Cheng , He Fei , Ren Xue-Qun , Sun Shi-Yong , Wu Dong-Dong , Duan Shao-Feng , Ji Xin-Ying 
Published: March 2019

AbstractLung cancer is the leading cause of cancer-related mortality worldwide. PEST-containing nuclear protein (PCNP) has been found in the nucleus of cancer cells. Whether PCNP plays a role in the growth of lung adenocarcinoma is still unknown. In the present study, the results indicated that the level of PCNP in lung adenocarcinoma tissue was significantly higher than that in corresponding adjacent non-tumor tissue. Over-expression of PCNP promoted the proliferation, migration, and invasion of lung adenocarcinoma cells, while down-regulation of PCNP exhibited opposite effects. PCNP over-expression decreased apoptosis through up-regulating the expression levels of phospho (p)-signal transducers and activators of transcription (STAT) 3 and p-STAT5 in lung adenocarcinoma cells, whereas PCNP knockdown showed opposite trends. PCNP overexpression enhanced autophagy by increasing the expression levels of p-phosphatidylinositol 3-kinase (PI3K), p-Akt, and p-mammalian target of rapamycin (mTOR) in lung adenocarcinoma cells, however an opposite trend was observed in the sh-PCNP group. In addition, overexpression of PCNP showed the tumor-promoting effect on xenografted lung adenocarcinoma, while PCNP knockdown reduced the growth of lung adenocarcinoma via regulating angiogenesis. Our study elucidates that PCNP can regulate the procession of human lung adenocarcinoma cells via STAT3/5 and PI3K/Akt/mTOR signaling pathways. PCNP may be considered as a promising biomarker for the diagnosis and prognosis in patients with lung adenocarcinoma. Furthermore, PCNP can be a novel therapeutic target and potent PCNP inhibitors can be designed and developed in the treatment of lung adenocarcinoma.
Volatile organic compounds influence the interaction of the Eurasian spruce bark beetle (Ips typographus) with its fungal symbionts
Authors: Kandasamy Dineshkumar , Gershenzon Jonathan , Andersson Martin N , Hammerbacher Almuth 
Published: March 2019

Abstract
Insects have mutualistic symbioses with a variety of microorganisms. However, the chemical signals that maintain these insect−microbe relationships are poorly known compared to those from insect−plant symbioses. The spruce bark beetle, Ips typographus, the most destructive forest pest in Europe, has a symbiotic relationship with several fungi that are believed to contribute to its successful invasion of Norway spruce. Here we tested the hypothesis that volatile organic compounds (VOCs) emitted from fungal symbionts could be cues for bark beetles to recognize and distinguish among members of its microbial community. Behavioral experiments with fungi showed that immature adults of I. typographus are attracted to food sources colonized by their fungal symbionts but not to saprophytic fungi and that this attraction is mediated by volatile cues. GC-MS measurements revealed that the symbionts emitted VOCs. Testing the activity of these compounds on beetle antennae using single sensillum recordings showed that beetles detect many fungal volatiles and possess olfactory sensory neurons specialized for these compounds. Finally, synthetic blends of fungal volatiles attracted beetles in olfactometer experiments. These findings indicate that volatile compounds produced by fungi may act as recognition signals for bark beetles to maintain specific microbial communities that might have impact on their fitness.
Social networks and risk of delayed hospital arrival after acute stroke
Authors: Dhand Amar , Luke Douglas , Lang Catherine , Tsiaklides Michael , Feske Steven , Lee Jin-Moo 
Published: March 2019

AbstractArriving rapidly to the hospital after a heart attack or stroke is critical for patients to be within time windows for treatment. Prior research in heart attacks has suggested a paradoxical role of the social environment: those who arrive early are surrounded by nonrelatives, while those who arrive late are surrounded by spouses or family members. Here, we used network methods to more deeply examine the influence of social context in stroke. We examined the relationship of personal social networks and arrival time in 175 stroke patients. Our results confirmed the paradox by showing that small and close-knit personal networks of highly familiar contacts, independent of demographic, clinical, and socioeconomic factors, were related to delay. The closed network structure led to constricted information flow in which patients and close confidants, absent outside perspectives, elected to watch-and-wait. Targeting patients with small, close-knit networks may be one strategy to improve response times.
Dynamic viability of the 2016 Mw 7.8 Kaikōura earthquake cascade on weak crustal faults
Authors: Ulrich Thomas , Gabriel Alice-Agnes , Ampuero Jean-Paul , Xu Wenbin 
Published: March 2019

AbstractWe present a dynamic rupture model of the 2016 Mw 7.8 Kaikōura earthquake to unravel the event’s riddles in a physics-based manner and provide insight on the mechanical viability of competing hypotheses proposed to explain them. Our model reproduces key characteristics of the event and constraints puzzling features inferred from high-quality observations including a large gap separating surface rupture traces, the possibility of significant slip on the subduction interface, the non-rupture of the Hope fault, and slow apparent rupture speed. We show that the observed rupture cascade is dynamically consistent with regional stress estimates and a crustal fault network geometry inferred from seismic and geodetic data. We propose that the complex fault system operates at low apparent friction thanks to the combined effects of overpressurized fluids, low dynamic friction and stress concentrations induced by deep fault creep.
Hip load capacity cut-points for Astronaut Skeletal Health NASA Finite Element Strength Task Group Recommendations
Authors: Michalski Andrew S. , Amin Shreyasee , Cheung Angela M. , Cody Dianna D. , Keyak Joyce H. , Lang Thomas F. , Nicolella Daniel P. , Orwoll Eric S. , Boyd Steven K. , Sibonga Jean D. 
Published: March 2019

AbstractConcerns raised at a 2010 Bone Summit held for National Aeronautics and Space Administration Johnson Space Center led experts in finite element (FE) modeling for hip fracture prediction to propose including hip load capacity in the standards for astronaut skeletal health. The current standards for bone are based upon areal bone mineral density (aBMD) measurements by dual X-ray absorptiometry (DXA) and an adaptation of aBMD cut-points for fragility fractures. Task Group members recommended (i) a minimum permissible outcome limit (POL) for post-mission hip bone load capacity, (ii) use of FE hip load capacity to further screen applicants to astronaut corps, (iii) a minimum pre-flight standard for a second long-duration mission, and (iv) a method for assessing which post-mission physical activities might increase an astronaut’s risk for fracture after return. QCT-FE models of eight astronaut were analyzed using nonlinear single-limb stance (NLS) and posterolateral fall (NLF) loading configurations. QCT data from the Age Gene/Environment Susceptibility (AGES) Reykjavik cohort and the Rochester Epidemiology Project were analyzed using identical modeling procedures. The 75th percentile of NLS hip load capacity for fractured elderly males of the AGES cohort (9537N) was selected as a post-mission POL. The NLF model, in combination with a Probabilistic Risk Assessment tool, was used to assess the likelihood of exceeding the hip load capacity during post-flight activities. There was no recommendation to replace the current DXA-based standards. However, FE estimation of hip load capacity appeared more meaningful for younger, physically active astronauts and was recommended to supplement aBMD cut-points.