bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic behavior of coupled steel plate shear walls with simple boundary frame connections
Authors: Safari Gorji Meisam , Cheng J.J. Roger 
Published: December 2018

SummaryThe coupled steel plate shear wall (C‐SPSW) configuration has been investigated by researchers as a means of improving the overturning stiffness and architectural flexibility of SPSW structures. While C‐SPSWs have been shown to exhibit excellent seismic performance, the fabrication cost associated with the high number of moment‐resisting connections used in such systems is a potential detraction to their use as an economical solution. Past research has shown that the hysteresis response of SPSWs with simple frame connections is significantly pinched, and as such, most seismic codes prohibit their use in high seismic areas. However, when used in the C‐SPSW configuration, a dual system is formed in which the coupling beams not only improve resistance to overturning but also provide substantial lateral strength and energy dissipation capacity. This paper presents an exploration of the potential to improve the economy of C‐SPSWs by using the simple boundary frame connections. First, employing the principles of plastic analysis, an attempt is made to quantify the contribution of the coupling beams to the overall lateral load resistance of the system. Then, to evaluate the seismic performance of such C‐SPSW systems and allow for the comparison with that of the C‐SPSWs with rigid frames, several prototypes are designed and analyzed using a series of nonlinear response history and pushover analyses. The results indicated that the C‐SPSWs with simple boundary frames exhibited satisfactory seismic performance comparable with that of the C‐SPSWs with rigid frames under both the 10/50 and 2/50 hazard levels, while allowing for reduced fabrication costs.
High‐intensity exercise is associated with a better nutritional status in anorexia nervosa
Authors: Rizk Melissa , Kern Laurence , Lalanne Christophe , Hanachi Mouna , Melchior Jean‐Claude , Pichard Claude , Mattar Lama ,   EVHAN Group, Berthoz Sylvie , Godart Nathalie 
Published: December 2018

AbstractObjectiveOur aim is to investigate the links between duration and intensity of exercise and the nutritional status in terms of body composition in acute anorexia nervosa (AN) patients.MethodOne hundred ninety‐one hospitalized women suffering from AN were included. Exercise duration and intensity were assessed using a semistructured questionnaire. Body composition was measured using bioelectrical impedance. Linear multiple regression analyses were carried out using body mass index, fat‐free mass index, and fat mass index as dependent variables and including systematically exercise duration, exercise intensity, and other confounding variables described in the literature that were significantly associated with each dependent variable in univariate analysis.ResultsA lower BMI was linked to lower exercise intensity, AN restrictive type, and presence of amenorrhea. A lower FFMI was linked to lower exercise intensity, older age, AN restrictive type, and premenarchal AN. Duration of exercise was not linked to the nutritional status.ConclusionsExercising at higher intensity in AN is associated with a better nutritional status, thus, a better resistance to starvation. The impact of therapeutic physical activity sessions, adapted in terms of exercise intensity and patient's clinical status, should be evaluated during nutrition rehabilitation.
The Development of a Quadratic Functions Learning Progression and Associated Task Shells
Authors: Graf Edith Aurora , Fife James H. , Howell Heather , Marquez Elizabeth 
Published: December 2018

AbstractIn this report, we discuss background research on the development of student understanding of quadratic functions and present a provisional learning progression for quadratic functions and quadratic equations. We also describe task shells that are linked to the learning progression. The learning progression and task shells can be used as a starting point to develop tasks that assess student standing with respect to the theory of development. The intention is that this report should find an audience in both researchers and test developers.
Biostimulants research in some horticultural plant species—A review
Authors: Parađiković Nada , Teklić Tihana , Zeljković Svjetlana , Lisjak Miroslav , Špoljarević Marija 
Published: December 2018

AbstractDifferent substances from the natural origin which have beneficial effects on plant growth and development, stress resistance, and crop yield and quality can be called biostimulants or biostimulators. Their physiological effects depend on their composition as they contain various organic and mineral compounds which plants can use as metabolites, growth regulators, and nutrients; however, biostimulants cannot be considered biofertilizers. Biostimulants applied in plant production have been widely considered as an environment‐friendly agricultural practice—and so are now among tools used in sustainable agriculture. Here, we discuss the results of the biostimulants’ effect investigations performed in Croatia, focused on horticultural crops, with edible plant species, such as tomato, garlic, bell pepper, lettuce, strawberry, garden cress, and basil, as well as ornamentals, such as wild rose, wax begonia, Mexican and French marigold, moss rose, everlasting flower, common zinnia, English primrose, and scarlet sage. The investigated biostimulants were applied at all plant growth stages, from germination to full plant and fruit or flower commercial maturity, using the seed treatment, foliar application, or irrigation. To evaluate biostimulant effectiveness, various morphological, physiological, and quality traits were analyzed. In this wide array of studies, the evaluated biostimulants mostly enhanced seed and transplant vigor, stimulated vegetative growth, improved nutrient acquisition and distribution within the plant, increased antioxidative capacity of plant tissues, contributing to higher stress tolerance, and improved plant yield and fruit/flower quality. In general, the research reviewed here implies possible benefits of biostimulant application in horticultural production, especially in stressful growth conditions, such as the transplant stage, reduced fertilization, or incidence of other abiotic stress. Considering possible interactions among the contained physiologically active compounds, the effects on plants may depend on dose, time of treatment, growth conditions, and plant species. Therefore, further research of biostimulant applications in horticultural production is suggested.
Carbon dioxide mineralization for the disposition of blast‐furnace slag: reaction intensification using NaCl solutions
Authors: Ren Enze , Tang Siyang , Liu Changjun , Yue Hairong , Li Chun , Liang Bin 
Published: December 2018

AbstractCarbon dioxide mineralization for the disposition of blast‐furnace slag is an important method for reducing CO2 emissions and simultaneously dealing with solid waste from the steel industry. However, due to the stable structures and properties of blast‐furnace slag, low mineralization reaction efficiency is a key issue in this process and hinders industrial applications. This work presents a method for enhancing the CO2 mineralization reaction by the addition of salt solutions (e.g., NaCl 1 mol · L−1) in the slurry of the blast‐furnace slag (<75 μm). The results showed that CO2 mineralization efficiency could be greatly improved with a high CO2 storage amount of ∼280 kg · tBFS−1 at a liquid‐solid ratio (L/S ratio) of 10, a temperature of 150°C and CO2 pressure of 3 MPa. The mineralization process was systematically characterized to identify the mechanism for mineralization enhancement by saline solution. The results indicated that saline solution could accelerate the dissolution of Ca2+ in blast‐furnace slag, reduce the activity of water, and lead to high acidity in the solution, and thus facilitate mineralization and improve the reaction rate. The NaCl solution was not consumed and could be recycled in the process, suggesting that this approach could use the brine and saline water as the medium for solid waste treatment and CO2 emission reduction in high energy‐consuming industries such as mineral processing, power plants, and the steel industry. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd.
Stroke target identification guided by astrocyte transcriptome analysis
Authors: Rakers Cordula , Schleif Melvin , Blank Nelli , Matušková Hana , Ulas Thomas , Händler Kristian , Torres Santiago Valle , Schumacher Toni , Tai Khalid , Schultze Joachim L. , Jackson Walker S. , Petzold Gabor C. 
Published: December 2018

AbstractAstrocytes support normal brain function, but may also contribute to neurodegeneration when they become reactive under pathological conditions such as stroke. However, the molecular underpinnings of this context‐dependent interplay between beneficial and detrimental properties in reactive astrogliosis have remained incompletely understood. Therefore, using the RiboTag technique, we immunopurified translating mRNAs specifically from astrocytes 72 hr after transient middle cerebral artery occlusion in mice (tMCAO), thereby generating a stroke‐specific astroglial translatome database. We found that compared to control brains, reactive astrocytes after tMCAO show an enrichment of transcripts linked to the A2 phenotype, which has been associated with neuroprotection. However, we found that astrocytes also upregulate a large number of potentially neurotoxic genes. In total, we identified the differential expression of 1,003 genes and 38 transcription factors, of which Stat3, Sp1, and Spi1 were the most prominent. To further explore the effects of Stat3‐mediated pathways on stroke pathogenesis, we subjected mice with an astrocyte‐specific conditional deletion of Stat3 to tMCAO, and found that these mice have reduced stroke volume and improved motor outcome 72 hr after focal ischemia. Taken together, our study extends the emerging database of novel astrocyte‐specific targets for stroke therapy, and supports the role of astrocytes as critical safeguards of brain function in health and disease.
Who Are You?
Authors: Gilbert Susan 
Published: December 2018

AbstractAt a time when our views on practically everything are polarized, there's one thing that growing numbers of us agree on: we want genetic information about ourselves. About 15 million people have taken a direct‐to‐consumer genetic test, up from 4 million two years ago. Millions more are likely to give these tests as holiday gifts. Many people consider genetic findings deeply meaningful to their understanding of who they are. This information is a gift, but it is also a weight—a paradox that was the theme of a conference organized by my colleagues Erik Parens and Joel Michael Reynolds in October 2018. Genomic knowledge is a gift when, for example, it connects us with relatives whom we're glad to meet. But it is a weight when it pigeonholes us into categories that suggest racial differences and possibly stereotypes.
Of Monsters and Men
Authors: Kaebnick Gregory E. 
Published: December 2018

AbstractThe November‐December 2018 issue of the Hastings Center Report celebrates two anniversaries. In a supplement to the issue, the fifty‐year‐old debate about what “dead” means—a debate launched in 1968 by the publication of the Harvard report on brain death—is dissected and reinvigorated in a set of essays assembled by Robert Truog, of Harvard Medical School's Center for Bioethics, and The Hastings Center's Nancy Berlinger, Rachel Zacharias, and Mildred Solomon. Inside the regular issue, a set of essays celebrates the two‐hundredth anniversary of the publication of Frankenstein; or, The Modern Prometheus, the novel about death, dissection, and reinvigoration and a touchstone for much commentary about emerging biotechnologies. Elsewhere in the issue are contrasting perspectives on physician‐assisted death, and in the lead article, Danielle Wenner explores the requirement, often noted but recently challenged, that medical research must have “social value” to be worth conducting.
Unexpected Creatures: Procreative Liberty and the Frankenstein Ballet
Authors: Garland‐Thomson Rosemarie 
Published: December 2018

AbstractOne of the most recent and original adaptations of Mary Wollstonecraft (Godwin) Shelley's Frankenstein; or, The Modern Prometheus (1818) is the ballet version choreographed by Liam Scarlett and performed by the Royal Ballet in 2016 and the San Francisco Ballet in 2017 and 2018. What emerges from this translation is an economical, emotionally wrenching, and visually elegant drama of family tragedy from which we can draw a cautionary tale about contemporary bioethical dilemmas in family making that new and forthcoming biomedical technologies present. This performance of bodies interacting suggests the need for an ethics of acceptance and recognition as people navigate complex familial relationships involving procreative liberty, questions of moral personhood, and parental obligation. In the Frankenstein ballet, the narrative genre of dance—what I'll call “story in the flesh”—invites viewers to identify with the characters and enter into the complexity of interpersonal relations. The ballet becomes a compelling testimony about possible unintended outcomes set in motion by well‐intended fallible humans like themselves.
Identifying threshold storm events and quantifying potential impacts of climate change on sediment yield in a small upland agricultural watershed of Ontario
Authors: Shrestha Narayan Kumar , Allataifeh Nabil , Rudra Ramesh , Daggupati Prasad , Goel Pradeep K. , Dickinson Trevor 
Published: December 2018

AbstractAgricultural zones are significant sediment sources, but it is crucial to identify critical source areas (CSAs) of sediment yield within these zones where best management practices (BMPs) can be applied to the best effect in reducing sediment delivery to receiving water bodies rather than the economically nonviable alternative of randomly or sweepingly implementing BMPs. A storm event of a specific magnitude and hyetograph profile may, at different times, generate a greater or lesser sediment yield. The widely used agricultural nonpoint source (AGNPS) model was used to identify CSAs for sediment losses in Southwestern Ontario's agriculture‐dominated 374‐ha Holtby watershed. A storm threshold approach was adopted to identify critical periods for higher sediment losses. An AGNPS model for the Holtby watershed was set up, calibrated, and validated for run‐off volume, peak flow rate, and sediment yield for several storms. The calibrated and validated model was run for storms of increasing return periods to identify threshold storm events that would generate sediment yield greater than an acceptable value for early and late spring, summer, and fall seasons. Finally, to evaluate the potential impacts of climate change, we shifted shorter duration summer storms into spring conditions and quantified the changes in sediment yield dynamics. A 6‐hr, 7.5‐year early spring storm would generate sediment losses exceeding the acceptable limit of 0.34 t ha−1 for the season. However, summer storms (2 hr, up to 100 years) tended to generate sediment yields below those of an identifiable threshold storm. If such shorter duration summer storms occurred in spring, the sediment yield would increase by more than fivefold. A 5‐year future storm would generate an equivalent effect of a 100‐year current spring event. The high sediment delivery to be expected will have significant implications regarding the future management of water quality of receiving waters. Appropriate placement of BMPs at CSAs will thus be needed to reduce such high sediment delivery to receiving waters.
Impacts of Climate Change on Urban Extreme Rainfall and Drainage Infrastructure Performance: A Case Study in Wuhan City, China
Authors: Xiong Lihua , Yan Lei , Du Tao , Yan Pengtao , Li Lingqi , Xu Wentao 
Published: December 2018

AbstractThe design of stormwater drainage infrastructure in urban areas in China is based on the statistical stationary assumption of probability distribution of extreme rainfall, which is being increasingly challenged by climate change. However, quantitative assessment of the performance of urban drainage systems in response to climate change with the latest emission scenarios of the Coupled Model Intercomparison Project Phase 5 in China is quite limited. This study aims to investigate potential changes of extreme rainfall and their influence on drainage infrastructure in a representative urban area in Wuhan city, China. The Storm Water Management Model is established to investigate the response of drainage infrastructure to future design rainfall. It is found that the probability distribution of extreme rainfall for two historical sub‐periods (1961–1985 and 1986–2005) has changed, especially in the head and tail of the frequency curves. Furthermore, the design rainfall with return periods of 2, 3, 4 and 5 years increases more significantly than those of 10 and 20 years. Consequently, the incapability of the current drainage infrastructure in the study area is aggravated. Moreover, the results of SWMM modelling provide detailed information about the performance of current drainage infrastructure, which can provide technical support for future modifications of the current drainage infrastructure of the study area. © 2018 John Wiley & Sons, Ltd.
Apelin/APJ system: A potential therapeutic target for endothelial dysfunction‐related diseases
Authors: Cheng Jun , Luo Xuling , Huang Zhen , Chen Linxi 
Published: December 2018

AbstractAPJ is a G protein‐coupled receptor and its endogenous ligand is apelin. Studies have shown that apelin/APJ system is widely distributed in the body, especially highly expressed in the vascular endothelial cells (ECs). Numerous reports have demonstrated that apelin/APJ system plays an important role in the regulation of ECs function. Our lab has demonstrated that apelin‐13 is able to promote adhesion of monocyte‐human umbilical vein EC via 14‐3‐3, and reactive oxygen species‐autophagy signaling pathways. In this review, we concentrate on the regulatory mechanism of apelin/APJ system in EC, including promotion of proliferation, migration, and angiogenesis. Moreover, we also analyze the role of apelin/APJ on endothelial dysfunction‐related diseases including atherosclerosis, diabetes, hypertension, and myocardial infarction. Finally, we summarize the most commonly used agonists and antagonists of APJ. Therefore, apelin/APJ system is expected to be a therapeutic target for the treatment of endothelial dysfunction‐related diseases.
MALDI‐ and LDI‐MS saponin fingerprint of leaves and stick components of commercial yerba mate (Ilex paraguariensis)
Authors: Petroselli Gabriela , Parapugna Tamara L. , Lagorio M. Gabriela , Erra‐Balsells Rosa 
Published: December 2018

AbstractYerba mate (YM) is massively produced and consumed as an infusion in South America and spreading all over the world. This product is obtained from dried leaves of Ilex paraguariensis Saint Hilaire, mixed with fragments of dried branches (sticks). For its commercialization, YM must have a minimum percentage of leaves because its presence determines YM quality and price. Till today, a mechanical methodology to determine the relative amount of components (sticks, leaves, and powder) is used. There is not any modern analytical method that provides information for quick characterization of the YM components. Typical saponin fingerprints for leaves and sticks were found by using ultraviolet matrix‐assisted laser desorption ionization and ultraviolet laser desorption ionization mass spectrometry. Then, their possible application as useful tools for quick characterization of components of commercial YM (leaves and sticks) is presented. Furthermore, fingerprints obtained from authentic samples of Ilex paraguariensis and Ilex dumosa are also included and discussed. Each Ilex show typical saponin fingerprints for leaves and sticks.
Postmarketing surveillance on clinical use of edoxaban in patients with nonvalvular atrial fibrillation (ETNA‐AF‐Japan): Three‐month interim analysis results
Authors: Yamashita Takeshi , Koretsune Yukihiro , Ishikawa Mayumi , Shiosakai Kazuhito , Kogure Seiji 
Published: December 2018

AbstractBackgroundDirect oral anticoagulants are the first‐line drugs for anticoagulation therapy in nonvalvular atrial fibrillation (NVAF). However, a real‐world, large‐scale, clinical study on edoxaban has not been performed. Our ongoing postmarketing surveillance, ETNA‐AF‐Japan (Edoxaban Treatment in routiNe clinical prActice in patients with non‐valvular Atrial Fibrillation; UMIN000017011), was designed to collect such data.MethodsEnrollment started on 13 April 2015 and ended on 30 September 2017. Eligible patients were those diagnosed with NVAF who were to receive edoxaban for the first time and provided written consent for study participation. Baseline patient characteristics and adverse events (AEs) were collected.ResultsA total of 11 569 patients were enrolled. Data for 8157 patients in the first 3 months were analyzed. Mean age, body weight, creatinine clearance (CLcr), and CHADS2 score were 74.2 ± 10.0 years, 60.0 ± 12.6 kg, 64.0 ± 25.6 mL/min, and 2.2 ± 1.3, respectively. Female patients, and patients with age ≥75 years, body weight ≤60 kg, and CLcr <30 mL/min constituted 40.7%, 52.4%, 54.6%, and 4.7%, respectively. Patients with paroxysmal, persistent, and permanent AF constituted 46.1%, 38.7%, and 15.1%, respectively. Most patients (85.3%) received dosages according to the prescribing information, and 90.8% continued the medication for 3 months. Bleeding AEs occurred in 3.29%, including major bleeding in 0.29%.ConclusionsThe majority (90.8%) of patients continued medication and no significant safety concerns related to edoxaban were reported during the first 3 months of treatment. Clearer safety and efficacy profiles of edoxaban await data analyses after the 2‐year follow‐up period.
Source attribution matters: Mediation and moderation effects in the relationship between work‐to‐family conflict and job satisfaction
Authors: Zhao Kai , Zhang Mian , Kraimer Maria L. , Yang Baiyin 
Published: December 2018

SummaryOn the basis of the source attribution perspective of work–family conflict, this study aims to first test whether threat to the family role mediates the relationship between work‐to‐family conflict and job satisfaction. We then examine boundary conditions of the source attribution perspective by drawing on boundary management and gender role orientation theories to examine whether role segmentation enactment and gender role orientation moderate the relationship between work‐to‐family conflict and job satisfaction. Using a scenario‐based experiment in Study 1, we find that threat to the family role mediates the relationship between work‐to‐family conflict and job satisfaction. This finding provides evidence supporting the appraisal process proposed by the perspective of source attribution. Using survey data collected from 216 Chinese managers and their spouses in Study 2, we find that work‐to‐family conflict has a negative relationship with job satisfaction only among people with high levels of role segmentation between work and home. In addition, for male managers, the negative moderating effect of role segmentation enactment on the relationship between work‐to‐family conflict and job satisfaction is stronger for those with a nontraditional gender role orientation, compared with those with a traditional gender role orientation. Theoretical and managerial implications are discussed.