bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibromyalgia, sleep disturbance and menopause: Is there a relationship? A literature review
Authors: Dias Rejane Camila Alvarenga , Kulak Junior Jaime , Ferreira da Costa Eloise Haydeê , Nisihara Renato Mitsunori 
Published: October 2019

AbstractIntroductionFibromyalgia (FM) symptoms worsen in a significant portion of patients with the onset of menopause. Some patients report that their symptoms begin after menopause, suggesting a relationship between these entities. Sleep disturbance is a common condition in FM and menopause, and it is associated with chronic pain.Methods/ObjectivesSeveral electronic databases were searched, from the first available year to April 2018 to evaluate the publications that assessed the effects of menopause and sleep disturbance on the appearance or worsening of FM and the role of hormone therapy for these patients.ResultsThe results are summarized in three tables. The objective sleep patterns of FM patients included high sleep latency, frequent arousals and intrusion of alpha wave sleep and NREM (non‐rapid eye movement) sleep in delta sleep. Poor sleep during menopause is more frequent in late perimenopause and surgical menopause, and may be related to vasomotor symptoms or not. Hormone therapy exerted a positive effect on subjective sleep quality of symptomatic menopausal women. Studies have shown a high association between FM and early and surgical menopause. Raloxifene exerted a positive effect on pain and sleep in FM patients; however one study that analyzed the effects of transdermal estrogen therapy found no improvement in subjective and objective parameters of pain.ConclusionFurther studies are needed to elucidate the nature of the association between menopause, sleep and persistent pain syndromes, such as FM, showing the role of hormone therapy in prospective placebo‐controlled trials.
Think before you prescribe: how dentistry contributes to antibiotic resistance
Authors: Sukumar S , Martin FE , Hughes TE , Adler CJ 
Published: October 2019

AbstractAntibiotic resistance presents a daunting challenge to health professionals worldwide and has the potential to create major problems for modern health care, resulting in more medical expenditure, extended hospital stays and increased morbidity and mortality. Advanced genome sequencing technologies present a complex picture of resistance, extending our understanding beyond the pharmacotherapeutic interface between pathogens and antibiotics. This review discusses the global scope and scale of antibiotic resistance and contextualizes it for the dental practitioner, emphasizing the role we must play in limiting the progression of resistance through antibiotic stewardship and disease prevention.
Urban‐rural comparisons in health risk factor, health status and outcomes in Tianjin, China: A cross‐sectional survey (2009‐2013)
Authors: Luo Da , Du Jiajun , Wang Pei , Yang Wenxiu 
Published: October 2019

AbstractObjectiveTo investigate the urban‐rural disparities in health risk factors, health status and outcomes in Tianjin, China and to make an international comparison with urban‐rural health in Australia.DesignA descriptive analytical cross‐sectional survey.SettingMobile research teams conducted door‐to‐door field surveys of each house or department. The teams included local administrative staff and Tianjin Center for Disease Control and Prevention's epidemiologists, clinicians and laboratory technicians.ParticipantsA total of 25 288 residents were interviewed and clinically observed, including 8583 urban residents and 16 705 rural residents.Main outcome measureHealth risk factors, health status and outcomes.ResultsThe age structure in urban areas of Tianjin was growing older. Rural residents received less high school education and university education than did urban residents. Urban residents had higher medical insurance coverage and paid more out‐of‐pocket medical expenditures than did rural residents. The prevalence of smoking and the crude alcohol consumption rate were higher in rural areas than in urban areas. Rural residents had feelings of higher self‐satisfaction concerning their health status than did urban residents. The prevalence of hypertensive disease, type 2 diabetes and heart, stroke and vascular diseases were significantly lower in rural areas than in urban areas. The incidence rate of serious injuries resulting from traffic accidents was significantly higher in rural areas than in urban areas.ConclusionContrary to Australian urban‐rural survey outcomes, the health status and outcomes of residents in rural areas of Tianjin seemed to be better than those of their counterparts in urban areas. The underlying determinants of these outcomes need to be explored with further study.
Laughing about Corruption in Ethiopian‐Chinese Encounters
Authors: Driessen Miriam 
Published: October 2019

ABSTRACTIn Ethiopia, the growing Chinese presence has inspired lively debate, often with an edge of humor. Corruption is one of the recurring topics in amusing narratives that circulate on and off the Chinese‐run building sites that have emerged across the Ethiopian landscape over the past two decades. While humorous corruption stories hint at the possibility of corruption and introduce the audience to the cultural codes of conduct, corrupt practices, equally aided by laughter, create instances of collaboration and complicity. Corruption in cross‐cultural encounters serves as a lens through which to imagine the Other and evaluate their behavior, and by drawing those complicit in corrupt transactions into shared (im)moral worlds, it generates opportunities for rapprochement. [corruption, humor, encounter, Ethiopia, China]
Does vegetation matter for the criminal behavior among people with serious mental illness?
Authors: Han Woojae , Marzell Miesha , Deng Chengbin 
Published: October 2019

AbstractThis study attempts to examine the effect of vegetation on arrests of offenders with and without serious mental illness (SMI). Data from the MacArthur mental health court study were analyzed. Objective arrest data were obtained 12–18 months pre‐ and post‐court involvement between 2005 and 2007. Vegetation data were captured by the normalized difference vegetation index, which can be regarded as a general measure of “vegetation” and linked with GeoID, obtained from the American Community Survey. We analyzed data of sociodemographic factors (e.g., age, gender), crime‐related factors (e.g., age of first arrest), and vegetation in related to the crime on 652 offenders with mental illness. Multilevel negative binomial regression revealed no significant effect of vegetation on arrests among offenders without SMI; however, for those with SMI, a significant variation in vegetation on arrests was found among all study models. Our findings suggest that vegetation is significantly associated with arrests, with a positive effect on reducing the recidivism only among offenders with SMI. Given that practice and policy almost exclusively focus on individual factors of crimes, it is important to have more considerations about how neighborhood factors affect criminal behavior, depending on SMI in order to have more comprehensive methods of crime prevention.
Out‐of‐pocket expenditure on health care by Australian mothers: Lessons for maternal universal health coverage from a long‐established system
Authors: Callander Emily J. , Topp Stephanie , Fox Haylee , Corscadden Lisa 
Published: October 2019

AbstractBackgroundDesigning effective universal health care systems has challenges, including the use of patient co‐payments and the role of the public and private systems. This study sought to quantify the total amount of out‐of‐pocket fees incurred by women who gave birth in private and public hospitals within Australia—a country with universal health coverage—and assess the impact that variation in birth type has on out‐of‐pocket fees.MethodsData came from a linked administrative data set of all women who gave birth in the Australian state Queensland between July 1, 2012, and June 30, 2015, plus their resultant children. Propensity score matching was used to create two similar cohorts of women who gave birth in private and public hospitals.ResultsThe mean total out‐of‐pocket fees for care from conception to the child's first birthday was $2813 (±2683 standard deviation) and $623 (±1202) for women who gave birth in private and public hospitals, respectively. Total fees were higher in both public and private hospitals for women who had a cesarean birth ($716 [±1419] and $3010 [±2988]) than for women who had a vaginal birth without instruments ($556 [±1044] and $2560 [±2284]).DiscussionAustralia's strong policy incentives for women to take out private health insurance are leaving women with large out‐of‐pocket costs. This should hold important lessons for other countries implementing a universal health care system, to ensure that using a combination of public and private practitioners does not undermine the intention of universal care.
Pilot study investigating the effect of enteral and parenteral nutrition on the gastrointestinal microbiome post‐allogeneic transplantation
Authors: Andersen Sarah , Staudacher Heidi , Weber Nicholas , Kennedy Glen , Varelias Antiopi , Banks Merrilyn , Bauer Judy 
Published: October 2019

SummaryNutrition support is frequently required post‐allogeneic haematopoietic progenitor cell transplantation (HPCT); however, the impact of mode of feeding on the gastrointestinal microbiome has not been explored. This study aimed to determine if there is a difference in the microbiome between patients receiving enteral nutrition (EN) and parenteral nutrition (PN) post‐allogeneic HPCT. Twenty‐three patients received either early EN or PN when required. Stool samples were collected at 30 days post‐transplant and analysed with shotgun metagenomic sequencing. There was no difference in microbial diversity between patients who received predominantly EN (n = 13) vs. PN (n = 10) however patients who received predominantly EN had greater abundance of Faecalibacterium (P < 0·001) and ruminococcus E bromii (P = 0·026). Patients who had minimal oral intake for a longer duration during provision of nutrition support had a different overall microbial profile (P = 0·044), lower microbial diversity (P = 0·004) and lower abundance of faecalibacterium prausnitzii_C (P = 0·030) and Blautia (P = 0·007) compared to patients with greater oral intake. Lower microbial diversity was found in patients who received additional beta lactam antibiotics (P = 0·042) or had a longer length of hospital stay (P = 0·019). Post‐HPCT oral intake should be encouraged to maintain microbiota diversity and, if nutrition support is required, EN may promote a more optimal microbiota profile.
No excess long‐term mortality in stage I‐IIA Hodgkin lymphoma patients treated with ABVD and limited field radiotherapy
Authors: Lagerlöf Ingemar , Holte Harald , Glimelius Ingrid , Björkholm Magnus , Enblad Gunilla , Erlanson Martin , Fluge Øystein , Fohlin Helena , Fosså Alexander , Goldkuhl Christina , Gustavsson Anita , Johansson Ann‐Sofie , Linderoth Johan , Nome Ole , Palma Marzia , Åkesson Lisa , Østenstad Bjørn , Raud Cecilia , Glimelius Bengt , Molin Daniel 
Published: October 2019

SummaryWhen treating limited stage classical Hodgkin lymphoma (cHL), balancing treatment efficacy and toxicity is important. Toxicities after extended‐field radiotherapy are well documented. Investigators have aimed at reducing toxicity without compromising efficacy, mainly by using combined modality treatment (CMT), i.e. chemotherapy and limited‐field radiotherapy. In some clinical trials, radiotherapy has been omitted. We evaluated 364 patients with stage I‐IIA cHL treated between 1999 and 2005. Patients were treated with two or four cycles of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) according to presence of risk factors, followed by 30 Gy limited‐field (reduced compared to involved‐field) radiotherapy. After a median follow‐up of 16 years for survival, freedom from progression at five and ten years was 93% and overall survival at 5 and 10 years was 98% and 96%, respectively. Only two relapses, out of 27, occurred after more than 5 years. There was no excess mortality compared to the general population. Of the analysed subgroups, only patients with progression within five years showed significant excess mortality. The absence of excess mortality questions the concept of omitting radiotherapy after short‐term chemotherapy, a strategy that has been associated with an elevated risk of relapse but not yet with a proven reduced long‐term excess mortality.
The 3D facies architecture and petrophysical properties of hyaloclastite delta deposits: An integrated photogrammetry and petrophysical study from southern Iceland
Authors: Greenfield Lois , Millett John M. , Howell John , Jerram Dougal A. , Watton Timothy , Healy David , Hole Malcolm J. , Planke Sverre 
Published: October 2019

AbstractHyaloclastites develop where lava interacts with water resulting in deposits that have a unique and often complex range of petrophysical properties. A combination of eruptive style and emplacement environment dictates the size, geometry and distribution of different hyaloclastite facies and their associated primary physical properties such as porosity, permeability and velocity. To date, links between the 3D facies variability within these systems and their petrophysical properties remain poorly understood. Hjörleifshöfði in southern Iceland presents an exceptional outcrop exposure of an emergent hyaloclastite sequence >1 km wide by >200 m high and enables an investigation of the distribution of the hyaloclastite deposits at seismic scale. Within this study we present a photogrammetry‐based 3D model from part of this recent hyaloclastite delta and incorporate previous work by Watton et al. (Journal of Volcanology and Geothermal Research, 2013, 250, 19) to undertake detailed facies interpretation and quantification. Laboratory petrophysical analyses were performed on 34 core plugs cut from key field facies samples, including P‐ and S‐wave velocity, density, porosity and permeability at both ambient and confining pressure. Integration of the 3D model with the petrophysical data has enabled the production of pseudo‐wireline logs and property distribution maps which demonstrate the variability of physical properties within hyaloclastite sequences at outcrop to seismic scale. Through comparison of our data with examples of older buried hyaloclastite sequences we demonstrate that the wide‐ranging properties of young hyaloclastites become highly uniform in older sequences making their identification by remote geophysical methods for similar facies variations more challenging. Our study provides an improved understanding of the petrophysical property distribution within hyaloclastite sequences and forms a valuable step towards improving the understanding of similar subsurface sequences and their implications for imaging and fluid flow.
Behavioural weight loss treatment preferences of college students with overweight and obesity
Authors: Bihuniak Jessica D. , Bryant Tiffany , Kleiman Jennifer , Rotondo Megan , Decoteau Jessica , Haisley Samantha , Monserrate David , Cunningham Michael , MacKenzie Allison , Dauz Steve , Ippolito Rosann , Fernandes Nicolle , LaRose Jessica G. , Leahey Tricia M. 
Published: October 2019

SummaryThe college environment increases risk of weight gain in young adults with overweight/obesity. Behavioural weight loss interventions are proven effective, however, young adults' adherence to such programs is poor. The purpose of the study was to determine weight loss treatment preferences of 2‐ and 4‐year college students for the development of population‐specific interventions. Students with a BMI ≥25, between 18 and 24 years of age, and enrolled in one of four institutions were recruited. A questionnaire was developed to assess students' preferences and was administered via Qualtrics. BMI was calculated from objectively assessed height and weight measurements. Descriptive analyses, chi‐square, Fisher's Exact Test, Mann‐Whitney U test and Cramer's V were performed. Participants (n = 133, age = 20.2 ± 1.8) predominately identified as female (70%), non‐Hispanic (68%) and Black/African American (32%) or White (32%). Fifty‐five percent met criteria for obesity. Most students preferred session length of ≤1 hour (78%), for meetings to be held on a weekday (70%) and for both a peer and a professional to co‐facilitate meetings (61%). Preferences for health outcomes and physical activity monitoring, type of physical activity, frequency of dietary monitoring, physical activity tracking method and interest in financial incentives to promote core treatment components differed between institutions. Heterogeneity in program preferences by college environment should be considered when designing weight loss interventions.
Identification of transgene integration site and anatomical properties of fluorescence intensity in a EGFP transgenic chicken line
Authors: Tsujino Kaori , Okuzaki Yuya , Hibino Nobuyuki , Kawamura Kazuki , Saito Seiji , Ozaki Yumi , Ishishita Satoshi , Kuroiwa Atsushi , Iijima Shinji , Matsuda Yoichi , Nishijima Kenichi , Suzuki Takayuki 
Published: October 2019

AbstractTransgenic birds are commonly used for time‐lapse imaging and fate mapping studies in developmental biology. When researchers use transgenic birds expressing fluorescent protein, they need to understand the integration site of the transgene in the genome and the intensity of fluorescence in the tissues of interest. In this study, we determined the integration site of the transgene and fluorescence property of developing organs in our transgenic chicken line generated by lentivirus infection. The transgene was localized between exons 3 and 4 of MED27. Some homozygotes and heterozygotes appeared to be lethal at early embryonic stages. We performed histological analysis of EGFP expression in transgenic embryos at St. 14, 17, and 24 by immunohistochemistry with anti‐GFP antibody on paraffin sections. Next, we cut cryosections and quantified direct EGFP intensity from the transgene in each tissue without performing immunohistochemistry. These results revealed that EGFP intensity in each tissue was unique in developing embryos and changed according to developmental stages. Finally, we demonstrated that EGFP‐expressing cells in a micromass culture with co‐culturing wild‐type cells were clearly distinguishable via live cell imaging. These results provide essential information on the potential of our transgenic line and indicate that these transgenic chicken lines are useful for research associated with developmental biology.
A critical review of learning approaches for entrepreneurship education in a contemporary society
Authors: O'Brien Emma , Hamburg Ileana 
Published: October 2019

AbstractThe concept of entrepreneurship has evolved significantly in the last decade and is identified as a competence rather than as a skill, comprising many different behaviours, attributes and skills, including empathy, creativity, financial literacy, taking initiatives and identifying opportunities. The Entrepcomp framework outlined by the EU Commission in 2016 highlighted that entrepreneurship focused on all aspects of society, not just business. It defined entrepreneurship as “the value that is created, financial, cultural, or social”. The importance of entrepreneurship as a key facet of life has reinvented how it should be taught, leading to collaborative pedagogical models that facilitate the exchange, flow and co‐creation of knowledge between HEIs, businesses and communities.This article identifies the need forcollaborative pedagogical models to develop entrepreneurial skills. It explores if a hybrid of design thinking and problem‐based learning can satisfy the needs of entrepreneurship education in contemporary society.
Limited strongyle parasite occurrence in horses kept in an arid environment
Authors: Ramey D. W. , Nielsen M. K. 
Published: October 2019

SummaryThe objective of this study was to document the strongylid infection status of stabled horses residing in an arid environment with limited access to pasture. Faecal parasite examinations were conducted in a private equine practice in Southern California over a period of 7 years, from 2012 to 2018, from a variety of horses in seven different locations; not all horses living at these locations were studied. Results of all faecal examinations were obtained and tabulated, as to both total number of horses examined, as well as individual animals followed with at least four consecutive bi‐annual faecal examinations over a 2‐year period. A total of 851 faecal tests on 79 individual horses were performed during the 7‐year study period, and 78 (9%) were strongyle positive. By the end of the study period, during which horses were monitored and treated according to faecal flotation tests, 97% of 117 faecal flotation tests were negative for strongyle parasites. In conclusion, in a population of 79 adult horses living in dry, arid conditions, with little or no access to pasture, frequent deworming for strongylid parasites would appear to be less necessary than in other environments. Regular faecal monitoring of horses in such conditions is appropriate for determining the necessary level of anthelmintic intervention.
A Randomized Phase 2 Study of Erenumab for the Prevention of Episodic Migraine in Japanese Adults
Authors: Sakai Fumihiko , Takeshima Takao , Tatsuoka Yoshihisa , Hirata Koichi , Lenz Robert , Wang Yi , Cheng Sunfa , Hirama Toshiyasu , Mikol Daniel D. 
Published: October 2019

ObjectiveA phase 2, double‐blind, placebo‐controlled study to evaluate the efficacy and safety of erenumab for the prevention of episodic migraine in Japanese patients was conducted.BackgroundPrevious global clinical studies have demonstrated the efficacy of erenumab in the prevention of migraine.MethodsPatients were randomized to placebo or erenumab 28, 70, or 140 mg administered subcutaneously once per month for 6 months. The primary endpoint was change from baseline in mean monthly migraine days over months 4‐6 of the double‐blind treatment phase. Secondary endpoints included the proportion of patients achieving ≥50% reduction from baseline in mean monthly migraine days (≥50% response) and change from baseline in mean monthly acute migraine‐specific medication treatment days (MSMD) and mean Headache Impact Test (HIT‐6™) scores. Efficacy outcomes were also determined at months 1, 2, and 3.ResultsFour hundred and seventy five patients were randomized 2:1:2:2 to placebo and erenumab 28, 70, and 140 mg, respectively. Greater reductions in monthly migraine days were observed for erenumab vs placebo with differences of –1.25 (95% CI: –2.10 to –0.41; P = .004), –2.31 (95% CI: –3.00 to –1.62; P < .001), and –1.89 (95% CI: –2.58 to –1.20; P < .001) days for erenumab 28, 70, and 140 mg. The odds of having a ≥50% response were 3.2, 5.6, and 4.7 times greater for erenumab 28 mg (95% CI: 1.30‐7.88; P = .009), 70 mg (95% CI: 2.60‐12.06; P < .001), and 140 mg (95% CI: 2.24‐9.99; P < .001) than for placebo. Greater reductions from baseline in mean acute monthly MSMD were observed for erenumab vs placebo with differences of –1.07 (95% CI: –1.80 to –0.35; P = .004), –2.07 (95% CI: –2.66 to –1.49; P < .001), and –2.04 (95% CI: –2.63 to –1.45; P < .001) days for erenumab 28, 70, and 140 mg. Erenumab 70 and 140 mg also resulted in greater improvements in HIT‐6™ scores. The safety profile was similar across treatment groups. The most common adverse event was nasopharyngitis, which occurred in 29.4% of patients in the placebo group and 28.9%‐33.3% of patients in the erenumab groups.ConclusionMonthly subcutaneous injections of erenumab 70 mg demonstrated statistically significant and numerically maximal efficacy with a favorable safety profile, suggesting that erenumab is a potential new therapy for migraine prevention in Japan.