bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive effects of brief and ultrabrief pulse bitemporal electroconvulsive therapy: a randomised controlled proof-of-concept trial
Authors: Martin Donel , Katalinic Natalie , Hadzi-Pavlovic Dusan , Ingram Anna , Ingram Nicholas , Simpson Brett , McGoldrick Jenny , Dowling Nathan , Loo Colleen 
Published: May 2019

AbstractBackgroundReduction of the pulse width has been reported to improve ECT outcomes with unilateral ECT (similar efficacy, fewer cognitive side effects), but has been minimally studied for bitemporal ECT. The only study comparing brief and ultrabrief pulse bitemporal ECT found reduced efficacy for bitemporal ultrabrief compared to bitemporal brief pulse stimulation. This randomised controlled trial (RCT) aimed to test if ultrabrief pulse bitemporal ECT results in fewer cognitive side effects than brief pulse bitemporal ECT, when given at doses adjusted with the aim of achieving comparable efficacy.MethodsThirty-six participants were randomly assigned to receive ultrabrief (at 3 times seizure threshold) or brief (at 1.5 times seizure threshold) pulse bitemporal ECT given 3 times a week in a double-blind, controlled proof-of-concept trial. Blinded raters assessed mood and cognitive functioning over the ECT course.ResultsEfficacy and cognitive outcomes did not differ significantly between the two treatment groups over the ECT course. The ultrabrief pulse group performed better on a test of visual memory assessed acutely after an ECT treatment.ConclusionsThis study suggests there may be a small cognitive advantage in giving bitemporal ECT with an ultrabrief pulse when dosage is increased to match the efficacy of brief pulse bitemporal ECT, but the study was underpowered to fully examine this issue.Clinical Trials Registration: www.clinicaltrials.gov, NCT00870805.
Patient Preferences Concerning Alternative Treatments for Neuroendocrine Tumors: Results of the “PIANO-Study”
Authors: Mühlbacher Axel C. , Juhnke Christin 
Published: May 2019

AbstractObjectivesNeuroendocrine tumors (NETs) are rare, slow-growing malignant tumors. So far, there are no data on patient preferences regarding its therapy. This empirical study aimed to elicit patient preferences in the drug treatment of NET.MethodsBased on qualitative patient interviews and an analytic hierarchy process, six patient-relevant attributes were analyzed and weighted using a discrete-choice experiment. Patients were recruited with the help of a NET support group. An experimental 3*3 + 6*3 –MNL design was created using NGene. The design consisted of eighty-four choices, divided into seven blocks. Participants were randomly assigned to these blocks. The analysis included random parameter logit and latent class models.ResultsA total of 275 participants (51.6 percent female; mean age, 58.4 years) were included. The preference analysis within the random parameter logit model, taking into account the 95 percent confidence interval, showed predominance for the attribute “overall survival.” The attributes “response to treatment” and “stabilization of tumor growth” followed. The side effects “nausea/vomiting” and “diarrhea” were considered of relatively equal importance. Latent class analysis of possible subgroup differences revealed three preference patterns.ConclusionsPreferences can influence therapeutic decisions. Preference analyses indicated that “overall survival” had the strongest influence, with participants clearly weighing outcome attributes higher than side effect attributes. In conclusion, mono-criterial decisions would not fully reflect patient perspectives.
Clobazam as Add-on Therapy in Children with Epileptic Encephalopathy
Authors: Silva Rosana Carvalho , Montenegro Maria Augusta , Guerreiro Carlos A.M. , Guerreiro Marilisa M. 
Published: May 2019

ABSTRACT:Rationale:Clobazam has been used successfully in adults and children with partial epilepsy. The purpose of this study was to evaluate the safety and efficacy of clobazam as add-on therapy in children with epileptic encephalopathy.Methods:This was a retrospective study conducted at the pediatric epilepsy clinic of our university hospital. Children less than 18-years of age with epileptic encephalopathy were included in the study. Clobazam was introduced as add-on therapy, starting with 5 mg/Kg/day and increased in minimally effective doses, up to the maximum tolerated dose. Data were obtained from clinical files and follow-up visits.Results:Ninety-seven patients were included in the study (39 girls), aged between 1 and 17-years-old (mean = 9.9). Twenty-six patients had Lennox-Gastaut syndrome, seven had myoclonic astatic epilepsy, nine had West syndrome and, in 57 patients, the type of epileptic encephalopathy could not be determined. Clobazam dosage ranged from 5 to 60 mg/day (mean = 37.5 mg/day). Forty (41%) patients presented with adverse events, most of which were mild and transitory, and clobazam needed to be withdrawn in only 11 patients. Nine (9.2%) patients were seizure-free after clobazam adjunctive therapy. In 11 (11.3%) patients seizure improvement was >75%, in 16 (16.5%) it was >50%, in 17 (17.5%) improvement was <50% and in 44 (45.5%) there was no change in seizure frequency. Three patients were lost to follow-up. In 85% of the patients with seizure improvement, the results lasted for more than one year.Conclusion:Clobazam is safe and effective in the treatment of epileptic encephalopathies of childhood.
Variable past participles in Portuguese perfect constructions
Authors: Schwenter Scott A. , Hoff Mark , Christodulelis Eleni , Pflum Chelsea , Dauphinais Ashlee 
Published: May 2019

AbstractSome Portuguese verbs have two past participle forms: one regular (stem +-do), and the other irregular (often identical to the first person singular present indicative). Per grammars, the perfect auxiliariester/havertake regulars, while irregulars appear with passive/adjectivalser/estar. To test these claims, we analyzed naturally-occurring data from Brazil (twentieth century) and Portugal (nineteenth and twentieth). We coded 1077 tokens from 21 verbs for ten predictors and performed mixed-effects logistic regressions in R. Irregulars appear withter/haver54% overall and in 68% of cases from Portugal. Our results demonstrate that past participle choice is determined by the interaction of several linguistic factors. While lexical verb is the most significant predictor of participle selection, verbs with irregular participles identical to the first person singular present indicative occur in the irregular significantly more than other verbs. We conclude that analogical processes underpin the variation. This conclusion allows us to adjudicate between competing accounts of past participle choice in Portuguese.
Medical Control Decisions: When Does a Neonate Become a Separate Patient?
Authors: Venegas Ashley , Ann Maggiore W. , Wells Radosveta , Baker Russell , Watts Susan 
Published: May 2019

Patient refusal for care or transport is a common request to medical control physicians, and it is an especially challenging decision in the case of minors. Parents or guardians are able to refuse medical care for a minor if there is not an imminent threat of harm to the minor. However, if a minor patient is presumed to be in need of emergent medical care to prevent harm, medical personnel have the right to treat the minor, even if the parent or guardian objects. If the minor patient is a fetus or a neonate, it is not always clear when they are considered to be a separate patient. Apparently, there is no over-riding general rule or law and, consequently, Emergency Medical Services (EMS) protocols vary greatly from state to state. This case report describes one patient case that involved some of these unclear legal areas and how it fit with local EMS protocols. The legal question arose when a pregnant patient delivered her baby, but the umbilical cord was not cut. Are the mother’s rights violated by cutting the umbilical cord if she objects to the procedure? How is the medical control physician to decide when to go beyond established EMS protocols to ensure that the safest and most ethical care is provided to a patient in the field? Does the care of the infant or the mother take precedence? Continued analyses of cases are required to ensure that protocols and guidelines are protecting both patients and providers.Venegas A, Ann Maggiore W, Wells R, Baker R, Watts S. Medical control decisions: when does a neonate become a separate patient? Prehosp Disaster Med. 2019;34(2):224–225
The psychosis proneness: psychosis persistence model as an explanation for the association between urbanicity and psychosis
Authors: Spauwen Janneke , Van Os Jim 
Published: May 2019

AbstractGiven the relatively high attributable risks associated with urbanicity it is crucially important to learn more on how this exposure impacts on population risk for schizophrenia. Further elucidation of the environmental influences that currently go under the name of “urbanicity” therefore is a crucial step in unravelling the etiology of schizophrenia. In order to make the step from association to cause, a plausible mechanism detailing the pathway from impact of exposure to onset of psychotic symptoms is needed. This paper outlines possible avenues and clues to the identification of possible mechanisms and pathways. The focus is on mechanisms of gene-environment interaction in the context of both functional genetic polymorphisms and epigenetic variation.
Disentangling associations between poverty at various levels of aggregation and mental health
Authors: Drukker Marjan , Gunther Nicole , van Os Jim 
Published: May 2019

AbstractThe present editorial discusses whether socioeconomic status of the individual and of the neighbourhood could be important in prevalence, treatment and prevention of psychiatric morbidity. Previous research showed that patients diagnosed with mental disorders are concentrated in socioeconomically disadvantaged areas. This could be the result of (1) an association between individual socioeconomic status and mental health, (2) an association between neighbourhood socioeconomic status and mental health, or (3) social selection. Research disentangling associations between individual and neighbourhood socioeconomic status on the one hand and mental health outcomes on the other, reported that neighbourhood socioeconomic disadvantage was associated with individual mental health over and above individual-level socioeconomic status, indicating deleterious effects for all inhabitants both poor and affluent. In conclusion, subjective mental health outcomes showed stronger evidence for an effect of neighbourhood socioeconomic status than research focussing on treated incidence. Within the group of patients, however, service use was higher in patients living in disadvantaged neighbourhoods. Social capital was identified as one of the mechanisms whereby neighbourhood socioeconomic disadvantage may become associated with observed reductions in mental health. After controlling for individual socioeconomic status, there is evidence for an association between neighbourhood socioeconomic status and objective as well as subjective mental health in adults. Evidence for such an association in young children is even stronger.
The diffusion and the reason for the use of complementary and alternative medicine among users of mental health services: a systematic review of literature
Authors: Pellegrini Nadia , Ruggeri Mirella 
Published: May 2019

SUMMARYAims- A systematic review of the studies on use of alternative and complementary medicine by mental health services' users to investigate the prevalence and motivations of CAM used to treat mental disorders.Methods- This paper shows a part of the results of a literature review, limited to studies between 1966 and 2005, was carried out using Ovid Medline, PsycINFO and EBM Reviews databases. This was supplemented by hand searching of reference lists.Results- Ninety-one studies on CAM's use by psychiatric patients were analyzed. In this paper the twenty-five articles about the CAM's prevalence and use's motivations are described. The use of complementary and alternative medicine (CAM) varies across countries: data suggest that from 50% to 80% of people suffering of mental disorders use CAM. Heterogeneous methods, samples and results characterizing the studies make generalizations results difficult. Patients motivations of CAM's use were poorly investigated by research, however it seems that persons affected by mental disorders use MAC prevalently because they are dissatisfied with conventional medicine and/or because these alternatives approaches are congruent with their own values, beliefs and philosophical orientation toward health care.Conclusions- The review emphasize the importance of a best physicians' education and information about CAM to improve the management of non-conventional and orthodox medicine relationship. The motivations of CAM's use underline the relevance of patient's holistic conception and the therapeutic role of a patient-physician relationship based on emphaty. Besides it seems important to investigate furtherly patients' psychological and social aspects that influence their choise to use CAM.
Development of a novel 3D immersive visualisation tool for manual image matching
Authors: Byrd B. , Warren M. , Fenwick J. , Bridge P. 
Published: May 2019

AbstractAim:The novel Volumetric Image Matching Environment for Radiotherapy (VIMER) was developed to allow users to view both computed tomography (CT) and cone-beam CT (CBCT) datasets within the same 3D model in virtual reality (VR) space. Stereoscopic visualisation of both datasets combined with custom slicing tools and complete freedom in motion enables alternative inspection and matching of the datasets for image-guided radiotherapy (IGRT).Material and methods:A qualitative study was conducted to explore the challenges and benefits of VIMER with respect to image registration. Following training and use of the software, an interview session was conducted with a sample group of six university staff members with clinical experience in image matching.Results:User discomfort and frustration stemmed from unfamiliarity with the drastically different input tools and matching interface. As the primary advantage, the users reported match inspection efficiency when presented with the 3D volumetric renderings of the planning and secondary CBCT datasets.Findings:This study provided initial evidence for the achievable benefits and limitations to consider when implementing a 3D voxel-based dataset comparison VR tool including a need for extensive training and the minimal interruption to IGRT workflow. Key advantages include efficient 3D anatomical interpretation and the capability for volumetric matching.
A New Model of the Crustal Magnetic Field of Mars Using MGS and MAVEN
Authors: Langlais Benoit , Thébault Erwan , Houliez Aymeric , Purucker Michael E. , Lillis Robert J. 
Published: May 2019

AbstractWhile devoid of an active magnetic dynamo field today, Mars possesses a remanent magnetic field that may reach several thousand nanoteslas locally. The exact origin and the events that have shaped the crustal magnetization remain largely enigmatic. Three magnetic field data sets from two spacecraft collected over 13 cumulative years have sampled the Martian magnetic field over a range of altitudes from 90 up to 6,000 km: (a) Mars Global Surveyor (MGS) magnetometer (1997–2006), (b) MGS Electron Reflectometer (1999–2006), and (c) Mars Atmosphere and Volatile EvolutioN (MAVEN) magnetometer (2014 to today). In this paper we combine these complementary data sets for the first time to build a new model of the Martian internal magnetic field. This new model improves upon previous ones in several aspects: comprehensive data coverage, refined data selection scheme, modified modeling scheme, discrete‐to‐continuous transformation of the model, and increased model resolution. The new model has a spatial resolution of ∼160 km at the surface, corresponding to spherical harmonic degree 134. It shows small scales and well‐defined features, which can now be associated with geological signatures.
Global Diagnostics of Ionospheric Absorption During X‐Ray Solar Flares Based on 8‐ to 20‐MHz Noise Measured by Over‐the‐Horizon Radars
Authors: Berngardt O. I. , Ruohoniemi J. M. , St‐Maurice J.‐P. , Marchaudon A. , Kosch M. J. , Yukimatu A. S. , Nishitani N. , Shepherd S. G. , Marcucci M. F. , Hu H. , Nagatsuma T. , Lester M. 
Published: May 2019

AbstractAn analysis of noise attenuation during 80 solar flares between 2013 and 2017 was carried out at frequencies 8–20 MHz using 34 Super Dual Auroral Radar Network radars and the EKB ISTP SB RAS radar. The attenuation was determined on the basis of noise measurements performed by the radars during the intervals between transmitting periods. The location of the primary contributing ground sources of noise was found by consideration of the propagation paths of radar backscatter from the ground. The elevation angle for the ground echoes was determined through a new empirical model. It was used to determine the paths of the noise and the location of its source. The method was particularly well suited for daytime situations, which had to be limited for the most part to only two crossings through the D region. Knowing the radio path was used to determine an equivalent vertical propagation attenuation factor. The change in the noise during solar flares was correlated with solar radiation lines measured by GOES/XRS, GOES/EUVS, SDO/AIA, SDO/EVE, SOHO/SEM, and PROBA2/LYRA instruments. Radiation in the 1 to 8 Å and near 100 Å are shown to be primarily responsible for the increase in the radionoise absorption, and by inference, for an increase in the D and E region density. The data are also shown to be consistent with a radar frequency dependence having a power law with an exponent of −1.6. This study shows that a new data set can be made available to study D and E regions.
Defensive Investment in Municipal Water Hardness Reduction
Authors: Farah Naima , Torell Gregory L. 
Published: May 2019

AbstractHousehold willingness to pay (WTP) for reductions in water hardness was estimated using a defensive investment framework. Using total dissolved solids data observed in municipal water supplies in combination with product‐by‐store level point‐of‐sale scanner data on consumable water softening product sales, we reveal preference estimates of WTP for water hardness reduction and quality control. Using instrumental variable regressions, we show that household marginal WTP increases as the observed total dissolved solids in municipal water increases. Estimations show that on average a household is willing to pay approximately $12 annually to reduce municipal water hardness, which is around 4% of the average annual water utility bill in the United States. Aggregated county WTP estimates vary geographically. Households have a nonnegligible WTP for water hardness reduction, which has important policy implications for optimal water hardness management by municipal water authorities and those policies aimed to target salinity management within surface and subsurface water supplies. Particularly, this paper informs municipal water managers of the demand side of water hardness issues and that desalination can be a solution to solve water hardness issues in some areas but not everywhere.
Impact of Irrigation on Regional Climate Over Eastern China
Authors: Kang Suchul , Eltahir Elfatih A.B. 
Published: May 2019

AbstractIrrigated area has rapidly expanded over the North China Plain (NCP), over the second half of the twentieth century. Simultaneously, there has been an observed increase in specific humidity and precipitation and a decrease in surface temperature during summer. The impacts of irrigation on regional climate in Eastern China are investigated using the Massachusetts Institute of Technology‐Regional Climate Model with irrigation module. The results of our experiments clearly support that surface cooling as well as enhanced precipitation are attributable to irrigation over the NCP. The irrigation‐induced soil moisture change simulated over the NCP during summer resulted in cooler surface temperatures by 1~4°C over this region, which led to a reduction of the planetary boundary layer, higher surface pressure, and significant changes in low‐level circulation. Our results indicate that moisture convergence is enhanced over Hebei and Henan province along the Taihang‐Mountain, which generated a significant increase in precipitation by 20~40% over this region.
Strain-induced reversible manipulation of orbital magnetic moments in Ni/Cu multilayers on ferroelectric BaTiO3
Authors: Okabayashi Jun , Miura Yoshio , Taniyama Tomoyasu 
Published: May 2019

AbstractControlling magnetic anisotropy by orbital magnetic moments related to interfacial strains has considerable potential for the development of future devices using spins and orbitals. For the fundamental physics, the relationship between strain and orbital magnetic moment is still unknown, because there are few tools to probe changes of orbital magnetic moment. In this study, we developed an electric field (E)-induced X-ray magnetic circular dichroism (EXMCD) technique to apply E to a ferroelectric BaTiO3 substrate. We reversibly tuned the interfacial lattice constants of Ni/Cu multilayers on BaTiO3 using this technique. As the domain structures in BaTiO3 are modulated by E, EXMCD measurements reveal that the changes in the magnetic anisotropy of Ni/Cu films are induced through the modulation of orbital magnetic moments in Ni with magneto-elastic contributions. The strained Ni layer that induces the perpendicular magnetic anisotropy without E is released at E = 8 kV/cm, and in-plane magnetization also occurs. We observed that EXMCD measurements clarified the origin of the reversible changes in perpendicular magnetic anisotropy and established the relationship between macroscopic inverse magnetostriction effects and microscopic orbital moment anisotropy.
Anomalous quantum oscillations and evidence for a non-trivial Berry phase in SmSb
Authors: Wu Fan , Guo Chunyu , Smidman Michael , Zhang Jinglei , Chen Ye , Singleton John , Yuan Huiqiu 
Published: May 2019

AbstractTopologically non-trivial electronic structures can give rise to a range of unusual physical phenomena, and the interplay of band topology with other effects such as electronic correlations and magnetism requires further exploration. The rare earth monopnictides X(Sb,Bi) (X = lanthanide) are a large family of semimetals where these different effects may be tuned by the substitution of rare-earth elements. Here we observe anomalous behavior in the quantum oscillations of one member of this family, antiferromagnetic SmSb. The analysis of Shubnikov-de Haas (SdH) oscillations provides evidence for a non-zero Berry phase, indicating a non-trivial topology of the α-band. Furthermore, striking differences are found between the temperature dependence of the amplitudes of de Haas-van Alphen effect oscillations, which are well fitted by the Lifshitz-Kosevich (LK) formula across the measured temperature range, and those from SdH measurements which show a significant disagreement with LK behavior at low temperatures. Our findings of unusual quantum oscillations in an antiferromagnetic, mixed valence semimetal with a possible non-trivial band topology can provide an opportunity for studying the interplay between topology, electronic correlations and magnetism.