bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibody Responses to Cancer Antigens Identify Patients with a Poor Prognosis among HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma Patients
Authors: Laban Simon , Gangkofner Dominik S. , Holzinger Dana , Schroeder Lea , Eichmüller Stefan B. , Zörnig Inka , Jäger Dirk , Wichmann Gunnar , Dietz Andreas , Broglie Martina A. , Herold-Mende Christel C. , Dyckhoff Gerhard , Boscolo-Rizzo Paolo , Ezić Jasmin , Marienfeld Ralf , Möller Peter , Kraus Johann M. , Völkel Gunnar , Kestler Hans A. , Brunner Cornelia , Schuler Patrick J. , Wigand Marlene C. , Theodoraki Marie-Nicole , Doescher Johannes , Hoffmann Thomas K. , Pawlita Michael , Waterboer Tim , Butt Julia 
Published: August 2019

Abstract

Purpose:
The identification of high-risk patients within human papillomavirus (HPV)-positive and -negative head and neck squamous cell carcinoma (HNSCC) is needed for improved treatment and surveillance strategies. In this study, we set out to discover antibody responses (AR) with prognostic impact in HNSCC stratified by HPV status.

Experimental Design:
A fluorescent bead–based multiplex serology assay on 29 cancer antigens (16 cancer-testis antigens, 5 cancer-retina antigens, and 8 oncogenes) and 29 HPV antigens was performed in samples of 362 patients with HNSCC from five independent cohorts (153 HPV positive, 209 HPV negative). A multivariable Cox proportional hazard model with bootstrapping (M = 1000) was used for validation of prognostic antibody responses.

Results:
Antibody response to any of the cancer antigens was found in 257 of 362 patients (71%). In HPV-negative patients, antibody responses to c-myc, MAGE-A1, -A4, and Rhodopsin E2 (combined as ARhigh risk) were significantly associated with shorter overall survival. In HPV-positive patients, antibody responses to IMP-1 were discovered as a negative prognostic factor. ARhigh risk (HR = 1.76) and antibody responses to IMP-1 (HR = 3.28) were confirmed as independent markers for a poor prognosis in a multivariable Cox proportional hazard model with bootstrapping (M = 1000).

Conclusions:
We identified antibody responses to cancer antigens that associate with a dismal prognosis in patients with HNSCC beyond HPV-positive status. ARhigh risk may be used to detect HPV-negative patients with an extraordinarily bad prognosis. Most importantly, antibody response to IMP-1 may serve as a marker for a subgroup of HPV-positive patients who present with a poor prognosis similar to that in HPV-negative patients.
Carta de Voltaire a Étienne-Noël Damilaville: tradução e comentário
Authors: Bedê Ana Luiza Reis 
Published: August 2019

Em 1765, Voltaire escreveu ao amigo Damilaville apresentando as motivações que o levaram a assumir a defesa do comerciante protestante Jean Calas e sua família. Na carta, relatou os principais momentos do caso, os percalços no caminho de sua resolução e introduziu o caso Sirven -que o ocuparia logo após obter a vitória no caso Calas. Embora a missiva seja endereçada a um único interlocutor, era na verdade destinada à impressão e distribuição entre o público letrado. Consideramos, por excelência, o documento como um libelo no qual o autor aproveita para discorrer sobre a missão dos filósofos.
Sex Differences in Long‐Term Survival After Major Cardiac Surgery: A Population‐Based Cohort Study
Authors: Johnston Amy , Mesana Thierry G. , Lee Douglas S. , Eddeen Anan Bader , Sun Louise Y. 
Published: August 2019

Background
Little attention has been paid to the importance of sex in the long‐term prognosis of patients undergoing cardiac surgery.

Methods and Results

We conducted a retrospective cohort study of Ontario residents, aged ≥40 years, who underwent coronary artery bypass grafting (CABG) and/or aortic, mitral, or tricuspid valve surgery between October 1, 2008, and December 31, 2016. The primary outcome was all‐cause mortality. The mortality rate in each surgical group was calculated using the Kaplan‐Meier method. The risk of death was assessed using multivariable Cox proportional hazard models. Sex‐specific mortality risk factors were identified using multiplicative interaction terms. A total of 72 824 patients were included in the study (25% women). The median follow‐up period was 5 (interquartile range, 3–7) years. The long‐term age‐standardized mortality rate was lowest in patients who underwent isolated
CABG
and highest among those who underwent combined
CABG
/multiple valve surgery. Women had significantly higher age‐standardized mortality rate than men after
CABG
and combined
CABG
/mitral valve surgery. Men had lower rates of long‐term mortality than women after isolated mitral valve repair, whereas women had lower rates of long‐term mortality than men after isolated mitral valve replacement. We observed a statistically significant association between female sex and long‐term mortality after adjustment for key risk factors.

Conclusions
Female sex was associated with long‐term mortality after cardiac surgery. Perioperative optimization and long‐term follow‐up should be tailored to younger women with a history of myocardial infarction and percutaneous coronary intervention and older men with a history of chronic obstructive pulmonary disease and depression.
Early Experience With Transcatheter Mitral Valve Replacement: A Systematic Review
Authors: del Val David , Ferreira‐Neto Alfredo Nunes , Wintzer‐Wehekind Jerome , Dagenais François , Paradis Jean‐Michel , Bernier Mathieu , O'Connor Kim , Beaudoin Jonathan , Freitas‐Ferraz Afonso B. , Rodés‐Cabau Josep 
Published: August 2019

Background

Transcatheter mitral valve replacement (
TMVR
) has emerged as an alternative therapeutic option for the treatment of severe mitral regurgitation in patients with prohibitive or high surgical risk. The aim of this systematic review is to evaluate the clinical procedural characteristics and outcomes associated with the early
TMVR
experience.

Methods and Results

Published studies and international conference presentations reporting data on
TMVR
systems were identified. Only records including clinical characteristics, procedural results, and 30‐day and midterm outcomes were analyzed. A total of 16 publications describing 308 patients were analyzed. Most patients (65.9%) were men, with a mean age of 75 years (range: 69–81 years) and Society for Thoracic Surgery Predicted Risk of Mortality score of 7.7% (range: 6.1–8.6%). The etiology of mitral regurgitation was predominantly secondary or mixed (87.1%), and 81.5% of the patients were in New York Heart Association class
III
or
IV
. A transapical approach was used in 81.5% of patients, and overall technical success was high (91.7%). Postprocedural mean transmitral gradient was 3.5 mm Hg (range: 3–5.5 mm Hg), and only 4 cases (1.5%) presented residual moderate to severe mitral regurgitation. Procedural and all‐cause 30‐day mortality were 4.6% and 13.6%, respectively. Left ventricular outflow obstruction and conversion to open heart surgery were reported in 0.3% and 4% of patients, respectively. All‐cause and cardiovascular‐related mortality rates were 27.6% and 23.3%, respectively, after a mean follow‐up of 10 (range: 3 to 24) months.

Conclusions

TMVR
was a feasible, less invasive alternative for treating severe mitral regurgitation in patients with high or prohibitive surgical risk.
TMVR
was associated with a high rate of successful valve implantation and excellent hemodynamic results. However, periprocedural complications and all‐cause mortality were relatively high.
The Tortricidae (Lepidoptera) of Bhutan
Authors: GROENEN FRANS , WANGDI KARMA 
Published: August 2019

Twenty-five species of Tortricidae from Bhutan are discussed, 14 of which are recorded for the first time: Acleris perfundana Kuznetsov, 1962, Archips limatus Razowski, 1977, Chirapsina expleta (Meyrick, 1923), Clepsis humana (Meyrick, 1912), Adoxophyes privatana (Walker, 1863), Lumaria probolias (Meyrick, 1907), Meridemis bathymorpha Diakonoff, 1976, Isodemis illiberalis Meyrick, 1918, Lobesia ambigua Diakonoff, 1954, Metendothenia ordospina Jirasuttayaporn & Pinkeaw, 2018, Gibberifera glaciata (Meyrick, 1907), Crocidosema plebejana Zeller, 1847, Lepteucosma charassuncus Razowski, 2006, and Microsarotis bicincta Diakonoff, 1976. Females of Chirapsina expleta and Epiblema charadrias Diakonoff, 1977 are described and illustrated for the first time. Nine new species are described: Eupoecilia jakarana, sp. nov., E. gedui, sp. nov., Lumaria phuntschona, sp. nov., Borneogena trashiyana, sp. nov., Bactra cophinana, sp. nov., Penthostola subnigrantis, sp. nov., M. brunnofasciana, sp. nov., Peridaedala nigrifasciana, sp. nov., and Epiblema albulusana, sp. nov. Adults and their genitalia are illustrated.
1. Past History and Deaths Foretold
Authors: Lisboa Maria Manuel 
Published: August 2019

Chapter One begins with an identification of a centuries-long poetic tradition – the worship of vanished female icons. Lisboa then examines the contrast between Eça de Queirós’ novel’s (The Sin of Father Amaro) portrayal of the female protagonist versus Paula Rego’s “empowered rendition” of that same character; and an analysis of three of Rego’s 1960s oppositional works that allude to political regimes and their leadership through the person, symbolism, and policies.
There is an exploration of Rego's mid-1980s to mid-90s move from both abstractionism and the cut-and-paste method to a more figurative mode; the “personal over the political” in these paintings, such as the Girl and Dog series; and Rego’s casting of reversed gender roles. Lisboa further considers the topics of sexuality, violence and religion in Rego’s paintings. Rego’s paintings are analyzed in great detail, and there is a discussion of her recurring signifiers and themes, including the sea and national loss, the colonialism, and her antagonistic portrayal of the “sailing adventures of the motherland.” There is an examination of Rego’s vision of national history and the political mismanagement “with anarchy always close to the surface.” The use and purpose of distorted scale in her paintings is explored. Finally, the discussion turns to a comparison between dog and man in Rego’s artwork, specifically in terms of the actions (either nurturing or harming) of girls toward dogs. The depiction of females as dogs in Rego’s paintings is contrasted with her portrayal of males in that role. Her representations of different animals are also discussed, including wolves and their connections to dogs and man.
Utilizing Precipitation and Spring Discharge Data to Identify Groundwater Quick Flow Belts in a Karst Spring Catchment
Authors: An Lixing , Ren Xingyuan , Hao Yonghong , Jim Yeh Tian-Chyi , Zhang Baoju 
Published: August 2019

Abstract
In karst terrains, fractures and conduits often occur in clusters, forming groundwater quick flow belts, which are the major passages of groundwater and solute transport. We propose a cost-effective method that utilizes precipitation and spring discharge data to identify groundwater quick flow belts by the multitaper method (MTM). In this paper, hydrological processes were regarded as the transformation of precipitation signals to spring discharge signals in a karst spring catchment. During the processes, karst aquifers played the role of signal filters. Only those signals with high energy could penetrate through aquifers and reflect in the spring discharge, while other weak signals were filtered out or altered by aquifers. Hence, MTM was applied to detect and reconstruct the signals that penetrate through aquifers. Subsequently, by analyzing the reconstructed signals of precipitation with those of spring discharge, we acquired the hydraulic response time and identified the quick flow belts. Finally, the methods were applied to the Niangziguan Spring (NS) catchment, China. Results showed that the hydraulic response time of the spring discharge to precipitation was 3 months at Pingding County; 4 months at Yuxian County, Yangquan City, Xiyang County, and Heshun County; and 27 months at Shouyang County and Zouquan County. These results suggested that Pingding County is located at a groundwater quick flow belt, which is a major passage of groundwater and contaminants, in the NS catchment. This is important since Pingding County is not only the key development area of karst groundwater but also the key conservation area for sustainable development of karst groundwater resources in NS catchment.
Testing the Assumptions Underlying Ocean Mixing Methodologies Using Direct Numerical Simulations
Authors: Taylor J. R. , de Bruyn Kops S. M. , Caulfield C. P. , Linden P. F. 
Published: August 2019

AbstractDirect numerical simulations of stratified turbulence are used to test several fundamental assumptions involved in the Osborn, Osborn–Cox, and Thorpe methods commonly used to estimate the turbulent diffusivity from field measurements. The forced simulations in an idealized triply periodic computational domain exhibit characteristic features of stratified turbulence including intermittency and layer formation. When calculated using the volume-averaged dissipation rates from the simulations, the vertical diffusivities inferred from the Osborn and Osborn–Cox methods are within 40% of the value diagnosed using the volume-averaged buoyancy flux for all cases, while the Thorpe-scale method performs similarly well in the simulation with a relatively large buoyancy Reynolds number (Reb ≃ 240) but significantly overestimates the vertical diffusivity in simulations with Reb < 60. The methods are also tested using a limited number of vertical profiles randomly selected from the computational volume. The Osborn, Osborn–Cox, and Thorpe-scale methods converge to their respective estimates based on volume-averaged statistics faster than the vertical diffusivity calculated directly from the buoyancy flux, which is contaminated with reversible contributions from internal waves. When applied to a small number of vertical profiles, several assumptions underlying the Osborn and Osborn–Cox methods are not well supported by the simulation data. However, the vertical diffusivity inferred from these methods compares reasonably well to the exact value from the simulations and outperforms the assumptions underlying these methods in terms of the relative error. Motivated by a recent theoretical development, it is speculated that the Osborn method might provide a reasonable approximation to the diffusivity associated with the irreversible buoyancy flux.
An impaired glucagon-like peptide-1 response is associated with prediabetes in polycystic ovary syndrome with obesity
Authors: Ferjan Simona , Jensterle Mojca , Oblak Tjasa , Zitnik Irena Prodan , Marc Janja , Goricar Katja , Dolzan Vita , Janez Andrej 
Published: August 2019

Objective Impaired glucose homeostasis in polycystic ovary syndrome (PCOS) is associated with obesity, age, and disease phenotype. This study aimed to investigate the glucagon-like peptide-1 (GLP-1) response in patients with obesity and PCOS with normal glucose tolerance (NGT) or prediabetes. Methods Twenty-six women with obesity and PCOS were included. Thirteen women had NGT and 13 had prediabetes. Serum glucose, insulin, and GLP-1 levels were measured during an oral glucose tolerance test. Beta-cell function and insulin resistance were determined. Results Women with prediabetes had significantly lower GLP-1 levels than did those with NGT after a glucose load. GLP-1 levels <3.02 pM at 120 minutes were associated with prediabetes. Women with prediabetes had a lower oral glucose insulin sensitivity (OGIS) index and greater amount of visceral adipose tissue than did those with NGT. Plasma GLP-1 levels at 120 minutes were correlated with visceral adiposity and the OGIS index. A change in GLP-1 levels was correlated with a family history of type 2 diabetes. Conclusion The GLP-1 response is lower in patients with obesity, PCOS, and prediabetes than in those with obesity, PCOS, and NGT. Further investigation of the GLP-1 response as a potential separate risk factor for prediabetes in PCOS is required.
Real-world efficacy and safety of liposomal irinotecan plus fluorouracil/leucovorin in patients with metastatic pancreatic adenocarcinoma: a study by the Korean Cancer Study Group
Authors: Yoo Changhoon , Im Hyeon-Su , Kim Kyu-pyo , Oh Do-Youn , Lee Kyung-Hun , Chon Hong Jae , Kim Joo Hoon , Kang Myoungjoo , Kim Ilhwan , Lee Guk Jin , Oh Sung Yong , Choi Younak , Choi Hye Jin , Kim Seung Tae , Park Joon Oh , Ryoo Baek-Yeol 
Published: August 2019

Background: Liposomal irinotecan (nal-IRI) plus 5-fluorouracil and leucovorin (5-FU/LV) was effective and well-tolerated in patients with metastatic pancreatic adenocarcinoma (mPAC) that progressed on gemcitabine-based therapy in the global NAPOLI-1 trial. Real-world data may further clarify the outcomes and safety profile of nal-IRI + 5-FU/LV in clinical practice. Methods: This retrospective analysis included patients with mPAC who received nal-IRI + 5-FU/LV following gemcitabine-based therapy under a Managed Access Program in Korea. Results: From January 2017 to April 2018, 86 patients across 10 institutions received nal-IRI + 5-FU/LV (median age, 61 years; 60% male; ECOG performance status, 0–1). A total of 35 (41%) and 51 (59%) patients had received less than two and two or more lines of chemotherapy before inclusion, respectively. At a median follow up of 6.4 months, median overall survival (OS) was 9.4 months (95% confidence interval [CI] 7.4–11.4) and median progression-free survival (PFS) was 3.5 months (95% CI 1.3–5.7). Six-month OS and PFS rates were 65.1% and 37.5%, respectively. Objective response and disease control rates were 10% and 55%, respectively. Most common grade 3–4 toxicities were neutropenia (37.2%), nausea (10.5%), vomiting (9.3%), anorexia (8.1%) and diarrhoea (4.7%). Conclusion: Real-life data for Korean patients indicate that, consistent with NAPOLI-1, nal-IRI + 5-FU/LV is effective and well-tolerated in patients with mPAC that progressed on gemcitabine-based therapy.
Very low-density lipoprotein cholesterol is associated with extent and severity of coronary artery disease in patients with type 2 diabetes mellitus
Authors: Jia Aimei , Zeng Wei , Yu Liuqin , Zeng Huirun , Lu Zhan , Song Yongyan 
Published: August 2019

Objective: Patients with type 2 diabetes mellitus usually have multiple cardiovascular disease risk factors. The objective of this study was to examine the severity and associated risk factors in coronary artery disease patients with type 2 diabetes mellitus. Methods: Two hundred and five coronary artery disease patients with type 2 diabetes mellitus and 205 age-, gender- and smoking-matched coronary artery disease patients without type 2 diabetes mellitus were recruited from the Department of Cardiology of our hospital. Demographic and clinical data were collected for all participants. Severity of coronary artery disease was assessed using Gensini scoring system, the number of diseased coronary arteries, and the extent of coronary stenosis. Results: Coronary artery disease patients with type 2 diabetes mellitus had higher Gensini scores (p < 0.01), more numbers of diseased coronary arteries (p < 0.001), and higher degrees of coronary stenosis (p = 0.05) than coronary artery disease patients without type 2 diabetes mellitus. The plasma levels of very low-density lipoprotein cholesterol (p < 0.001) and triglycerides (p < 0.001) were also higher in coronary artery disease patients with type 2 diabetes mellitus than in coronary artery disease patients without type 2 diabetes mellitus. In coronary artery disease patients with type 2 diabetes mellitus, very low-density lipoprotein cholesterol was positively correlated with Gensini scores (r = 0.15, p = 0.03), the number of diseased coronary arteries (r = 0.15, p = 0.04), and the extent of coronary stenosis (r = 0.14, p = 0.05) by partial correlation analysis after controlling for other lipid parameters, and independently associated with Gensini scores (beta = 0.18, p = 0.02) and the number of diseased coronary arteries (odds ratio = 2.09, p = 0.05) after adjusting for other cardiovascular risk factors in the following multiple regression analysis. Conclusion: Very low-density lipoprotein cholesterol may represent a marker for the severity of coronary artery disease and be a target for the treatment in diabetic patients. Further research is needed to determine whether very low-density lipoprotein cholesterol plays a causal role of coronary artery disease in diabetic patients.
Eccentric Reaming for B2 Glenoids: History, Preoperative Planning, Surgical Technique, and Outcome
Authors: Smith Matthew J , Loftis Christopher M , Skelley Nathan W 
Published: August 2019

Background The biconcave (B2) glenoid is characterized by preservation of the anterior portion of the native glenoid with asymmetric wear of the posterior glenoid. Surgical options for glenoid correction have evolved. The goal of shoulder arthroplasty is to place the implants in such a manner to return the humeral head to a centered position and restore the joint line to a neutral position. There is no current consensus on method of treatment and correction. Methods The current and historical literature on total shoulder arthroplasty was used to examine technique viability. Results Asymmetric remaining can be used to address up to 15° of version correction without compromise of cortical bone. It is important to have the proper presurgical planning, to understand the limitations of correction, and to have other options available to treat the biconcave glenoid.
Enhancing Case Capture, Quality, and Completeness of Primary Melanoma Pathology Records via Natural Language Processing
Authors: Malke Jared C. , Jin Shida , Camp Samuel P. , Lari Bryan , Kell Trey , Simon Julie M. , Prieto Victor G. , Gershenwald Jeffrey E. , Haydu Lauren E. 
Published: August 2019

PURPOSE Medical records contain a wealth of useful, informative data points valuable for clinical research. Most data points are stored in semistructured or unstructured legacy documents and require manual data abstraction into a structured format to render the information more readily accessible, searchable, and generally analysis ready. The substantial labor needed for this can be cost prohibitive, particularly when dealing with large patient cohorts. METHODS To establish a high-throughput approach to data abstraction, we developed a novel framework using natural language processing (NLP) and a decision-rules algorithm to extract, transform, and load (ETL) melanoma primary pathology features from pathology reports in an institutional legacy electronic medical record system into a structured database. We compared a subset of these data with a manually curated data set comprising the same patients and developed a novel scoring system to assess confidence in records generated by the algorithm, thus obviating manual review of high-confidence records while flagging specific, low-confidence records for review. RESULTS The algorithm generated 368,624 individual melanoma data points comprising 16 primary tumor prognostic factors and metadata from 23,039 patients. From these data points, a subset of 147,872 was compared with an existing, manually abstracted data set, demonstrating an exact or synonymous match between 90.4% of all data points. Additionally, the confidence-scoring algorithm demonstrated an error rate of only 3.7%. CONCLUSION Our NLP platform can identify and abstract melanoma primary prognostic factors with accuracy comparable to that of manual abstraction (< 5% error rate), with vastly greater efficiency. Principles used in the development of this algorithm could be expanded to include other melanoma-specific data points as well as disease-agnostic fields and further enhance capture of essential elements from nonstructured data.