bluuebunny/crossref_metadata_2025_split huggingface dataset:
Better care through an optimized mental health services continuum (Eastern Townships, Québec, Canada): A systematic and multisource literature review
Authors: Roy Mathieu , Dagenais Pierre , Pinsonneault Linda , Déry Véronique 
Published: October 2018

SummaryIntroductionIn 2014, the health authorities of the Eastern Townships (Québec, Canada) commissioned an evaluation of the mental health admission system for adults (GASMA) to identify the best GASMA organizational or structural elements and optimize the mental health services continuum.MethodsTo develop better services, seven indicators (ie, accessibility to services, integration of levels of services, user satisfaction, guidance and management time, evaluation tools, professional composition, and interprofessional collaboration) were examined through four evaluation questions. A three‐step systematic and multisource evaluation was realized. A systematic review of the scientific and gray literature was performed. This evaluation also included key informant opinions to contextualize results from this review.ResultsResults from 91 scientific articles, 40 gray literature documents, and 10 interviews highlighted determinants and barriers associated with the examined indicators. From these results, 24 preliminary recommendations were formulated and discussed in a steering committee. These recommendations were then weighted and validated. This served to formulate three final recommendations.ConclusionTo optimize the regional mental health services continuum, stakeholders should (1) implement a single‐window access for adults with mental health needs, (2) develop alternative services based on users' needs, and (3) test the effectiveness of new methods, initiatives, and tools.
Factors affecting job satisfaction among medical laboratory technologists in University Hospital, Oman: An exploratory study
Authors: Alrawahi Samira , Sellgren Stina Fransson , Alwahaibi Nasar , Altouby Salem , Brommels Mats 
Published: October 2018

SummaryBackgroundThe worldwide shortage of health care professionals has prompted Oman to recruit such professionals from other countries. Among such professionals, medical laboratory technologists are key in effective health care delivery, and it is therefore important to discover what influences the job satisfaction enjoyed by them. However, little research has been undertaken in this area; consequently, this study explores the factors that impact upon job satisfaction among medical laboratory technologists in University Hospital, Oman.MethodTwelve groups of professionals were involved in Focus Group Discussions. The participants comprised senior and junior medical laboratory technologists. The study was undertaken during the end of 2015 and the beginning of 2016. One general question was presented: Can you please describe your situation at work in this hospital?ResultsFactors that caused major dissatisfaction at work were identified as follows: workload, promotion, health and safety in the laboratory, relationship with the leaders, professional status (recognition and appreciation), and hospital policies such as appraisal. Stress was the outcome of the presence/absence/quality of these factors. Other factors that emerged as important were autonomy and professional development. The satisfaction factors were identified as salary, the co‐worker relationship, and job security for non‐Omanis.ConclusionsThese findings call for a reevaluation of the promotion system, improved health and safety within the laboratories, appraisal that relates to the technologists careers within their laboratories, and improved professional training programmes for career enhancement.
Comparative study on heat transfer enhancement of nanofluids flow in ribs tube using CFD simulation
Authors: Salman Sami D. 
Published: October 2018

AbstractThis study presents, a numerical investigation of two‐dimensional turbulent nanofluids flow in different ribs tube configurations on heat transfer, friction, and thermal performance coefficients using ANSYS‐FLUENT software version‐16. Governing equations of mass, momentum, and energy have been solved by means of a finite volume method (FVM). Four types of nanoparticles namely; Al2O3, CuO, SiO2, and ZnO with volume fraction range (1%‐4%) and different size of nanoparticles (dp = 30 nm, 40 nm, 50 nm, and 60 nm) with various Reynolds number (10 000‐30 000) in a constant heat flux tube with rectangular, triangular, and trapezoidal ribs were conducted for simulation. The results exhibit that Nusselt number for all cases enhanced with Reynolds number and nanofluid volume fraction increases. Likewise, the results also reveal that SiO2 with volume fractions of 4% and diameters of nanoparticles of 30 nm in triangular ribs offered the highest Nusselt number at Reynolds number of Re = 30 000. In addition, the higher value of thermal performance factor was obtained at Reynolds number of Re = 10 000.
Improved velocity and temperature profiles for integral solution in the laminar boundary layer flow on a semi‐infinite flat plate
Authors: Seyyedi S. M. , Dogonchi A. S. , Hashemi‐Tilehnoee M. , Ganji D. D. 
Published: October 2018

AbstractOne of the most important problems in Mechanical Engineering is the determination of laminar boundary layer thickness over a flat plate. Integral solution and similarity solutions are two well‐known methods for calculation of boundary layer thickness. However, integral solution method is a computational cost‐effective method rather than the similarity solution method. Velocity and temperature profiles must be determined for the integral solution method. Velocity boundary layer thickness can be determined by the velocity profile whereas for determination of thermal boundary layer thickness both velocity and temperature profiles must be used. Available velocity profiles do not give an exact value for velocity boundary layer thickness, while the Nusselt number is affected by these profiles. In this study, a new velocity profile is proposed which gives an exact value for laminar boundary layer thickness on a flat plate. In addition, two temperature profiles are proposed that give the exact values of the Nusselt number over a flat plate for uniform temperature and uniform heat flux boundary conditions. The calculated constants in the velocity boundary layer thickness equation and the Nusselt relations are validated with the results of the similarity solution method. Excellent agreement between the results of the two methods is observed.
Thermal and solutal Marangoni stagnation point Casson fluid flow over a stretching sheet in the presence of radiation, Soret and Dofour effect with chemical reaction
Authors: Shaw Sachin , Mahanta Ganeswar , Das Mrutyunjay 
Published: October 2018

AbstractThe Marangoni flow is involved with microgravity and earth gravity, which causes undesirable effects in crystal growth experiments. Crystal growth experiments were designed in such a manner so as to appraise MIR (space station), which is one of the best platforms for protein crystallization and radiation experiments. In this article, a model is proposed with a stagnation point and a Casson fluid flow at the interface of the plate in the presence of Marangoni convection influenced by a magnetic field and chemical reaction. Furthermore, it is considered that both temperature and concentration surface tension vary linearly with the interface. It is important to choose similarity transformations for implementing nonlinear differential equations into linear ordinary differential equations. We solved the system of differential equations using fourth order Range‐Kutta method with suitable shooting techniques, and the results are displayed through graphs. A comparison is made with the earlier existing literature, and it shows a very good agreement. The results and a detailed discussion of velocity, temperature, and concentration have been shown graphically. The favorable and unfavorable buoyancy force to Marangoni flow, the features of temperature and concentration field, have been investigated.
Numerical study of mixed convection nanofluid in an annulus enclosure between outer rotating cylinder and inner corrugation cylinder
Authors: Ali Farooq Hassan , Hamzah Hameed K. , Abdulkadhim Ammar 
Published: October 2018

AbstractNumerical investigations are presented for mixed convection problems in a concentric inner sinusoidal cylinder and an outer rotating circular cylinder, which were kept at constant hot and cold temperatures, respectively. The free space between the cylinders and the enclosure walls was filled with a water‐Cu nanofluid. The governing equations are formulated for velocity, pressure, and temperature formulation and are modeled in COMSOL5.2a, a partial differential equation solver based on the Galerkin finite element method. The governing parameters considered are the solid volume fraction, [0, 0.02, 0.04, and 0.06], Re (1, 25, 100, 200, and 300), and Ra (less than 104), and the inner cylinder corrugation frequencies varied from (N = 3, 6, and 9). According to the calculations, the Reynolds number, the Rayleigh number, the nanoparticle volume fraction, and the number of corrugations play an important role of forming the stream and isothermal lines, the local and the average Nusselt number inside the annulus enclosure. The average Nusselt number decreases with increasing Reynolds number and the number of corrugations, while it increases as the Rayleigh number and the volume fraction increase.
Non‐Newtonian squashed flow simulation across Darcy‐Forchheimer sensor
Authors: Hussain Azad , Zetoon Rabia , Ali Shoaib , Malik M. Y. 
Published: October 2018

AbstractThe current mathematical formulation is dedicated to investigate the Darcy‐Forchheimer boundary layer–squeezed hydromagnetic flow of a Casson fluid passing through a sensor surface. The flow phenomenon is occurring in a locally free stream under the combined sway of heat generation and thermic radiation. The energy equation is deliberated with the assistance of Cattaneo‐Christov theory rather than using Fourier's law for conduction of heat. Here, the thermic conductivity is being presumed as a function of temperature. The governing mathematical structure consists of highly nonlinear terms, so a set of regulatory parameters is being accomplished to attain the unpretentious dimensionless equations. This nondimensional structure is then treated numerically to attain the nearly converging results. The significance of substantial parameters such as magnetic factor, radiation parameter, Casson fluid parameter, heat origination, and thermal relaxation time on the flow phenomenon is estimated and presented graphically. Besides this, the factors of engineering interest like the Prandtl number and squeezed flow index with vacillating thermic conductivity have strong effects on the flow behavior of the fluid. It is observed that the magnetic effect causes an expansion in the velocity curve while a reduction is found for squeezed flow index parameter.
Effects of nonlinear Boussinesq approximation and double dispersion on a micropolar fluid flow under convective thermal condition
Authors: Srinivasacharya Darbhasayanam , RamReddy Chitteti , Naveen Padigepati 
Published: October 2018

AbstractThis article investigates the effect of double dispersion on the natural convective flow of a micropolar fluid along an inclined plate in the presence of the convective thermal condition. In addition, the nonlinear convection is considered to analyze the heat and mass transfer phenomena of thermal systems, which are performed at moderate‐ and high‐level temperatures. A combination of local nonsimilarity and successive linearization techniques is used to evaluate the associated complicated nondimensional governing equations. This study discusses the impact of relevant factors on the fluid characteristics through graphs. The influence of nonlinear convection parameters on the heat and mass transfer rates seems to be more in Darcy porous media compared with that in non‐Darcy porous media.
Numerical study of heat transfer and viscous flow in a dual rotating extendable disk system with a non‐Fourier heat flux model
Authors: Shamshuddin MD , Mishra S. R. , Bég O. Anwar , Kadir Ali 
Published: October 2018

AbstractNonlinear, steady‐state, viscous flow, and heat transfer between two stretchable rotating disks spinning at dissimilar velocities are studied with a non‐Fourier heat flux model. A nondeformable porous medium is intercalated between the disks and the Darcy model is used to simulate matrix impedance. The conservation equations are formulated in a cylindrical coordinate system and via the von Karman transformations are rendered into a system of coupled, nonlinear ordinary differential equations. The emerging boundary value problem is controlled by number of dimensionless parameters, that is, Prandtl number, upper disk stretching, lower disk stretching, permeability, non‐Fourier thermal relaxation, and relative rotation rate parameters. A perturbation solution is developed and the impact of selected parameters on radial and tangential velocity components, temperature, pressure, lower disk radial, and tangential skin friction components and surface heat transfer rate are visualized graphically. Validation of solutions with the homotopy analysis method is included. Extensive interpretation of the results is presented which are relevant to rotating disk bioreactors in chemical engineering.
Long non‐coding RNA SNHG16 has Tumor suppressing effect in acute lymphoblastic leukemia by inverse interaction on hsa‐miR‐124‐3p
Authors: Yang Tianxin , Jin Xing , Lan Jianping , Wang Wensong 
Published: October 2018

AbstractAcute lymphoblastic leukemia (ALL) is one of the deadly forms of childhood cancers in the world. In the present study, we used both in vitro and in vivo models to evaluate the functional mechanisms of a long noncoding RNA (lncRNA), small nucleolar RNA host gene 16 (SNHG16) in ALL. SNHG16 gene expression was evaluated by quantitative real‐time PCR (qPCR) in both in vitro ALL cell lines and in vivo human samples of T lymphocytes. Lentivirus‐mediated SNHG16 downregulation was performed in MOLT3 and SUP‐B15 cells, to evaluate its functional effects on ALL cell proliferation, migration in vitro, and ALL transplant in vivo. Epigenetic regulation of SNHG16 on human miR‐124‐3p (hsa‐miR‐124‐3p) was evaluated by dual‐luciferase activity assay and qPCR. Hsa‐miR‐124‐3p was inhibited in SNHG16‐downregulated MOLT3 and SUP‐B15 cells to further evaluate the functional correlation between SNHG16 and hsa‐miR‐124‐3p in ALL. SNHG16 is upregulated in both in vitro ALL cell lines and in vivo human leukemic T‐cells. SNHG16 downregulation suppressed ALL proliferation and migration in vitro, and ALL explant in vivo. Hsa‐miR‐124‐3p was demonstrated to interact with SNHG16, and upregulated in SNHG16‐downregulated ALL cells. In addition, inhibiting hsa‐miR‐124‐3p reversed SNHG16‐downregulation‐mediated tumor suppressive functions in ALL. SNHG16 is upregulated in ALL, and its inhibition has tumor suppressive effect in ALL, likely through epigenetic interaction on hsa‐miR‐124‐3p. © 2018 IUBMB Life, 71(1):134–142, 2019
Extracellular vesicle and mesenchymal stem cells in bone regeneration: recent progress and perspectives
Authors: Chu Chenyu , Wei Shimin , Wang Yuanjing , Wang Yufei , Man Yi , Qu Yili 
Published: October 2018

AbstractTransplanting mesenchymal stem cells (MSCs) has been widely perceived as an ideal treatment for bone repair and regeneration, owing to their differential potential. However, researchers found that very few intravenous MSCs could stay in the target tissue, whereas the majority of them are trapped in liver, spleen, and lung, largely reducing its therapeutic effects. Recently, extracellular vesicles (EVs) have attracted increased attention due to their function in bone repair and advantages over traditional cell therapy. Also, MSCs‐derived EVs are likely to achieve the osteogenic goal via modulating the cells and cytokines involved in bone metabolism. This review aims at summarizing the function of EVs and MSCs in bone metabolism and regeneration. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 243–250, 2019.
Preparation of nanoliposomes linked to HER2/neu‐derived (P5) peptide containing MPL adjuvant as vaccine against breast cancer
Authors: Rastakhiz Saeedeh , Yazdani Mona , Shariat Sheida , Arab Atefeh , Momtazi‐Borojeni Amir Abbas , Barati Nastaran , Mansourian Mercedeh , Amin Mohamdreza , Abbasi Azam , Saberi Zahra , Jalali Seyed Amir , Badiee Ali , Jaafari Mahmoud Reza 
Published: October 2018

AbstractThe study was aimed at evaluating antitumor and immunomodulatory effects of liposomal vaccine composed of P5 human epidermal growth factor receptor 2 (HER2)/neu‐derived peptide coupled to the surface of high‐temperature nanoliposomes containing distearoylphosphocholine:distearoylphosphoglycerol:Chol:dioleoylphosphatidylethanolamine (DOPE) comprising monophosphoryl lipid A (MPL) adjuvant in HER2/neu overexpressing the breast cancer model. BALB/c mice bearing TUBO carcinoma were subcutaneously immunized with formulations containing 10 µg P5 peptide and 25 µg MPL three times with 2‐week intervals. To determine immuno responses in immunized mice, the amount of released interferon‐γ and IL‐4 were measured by the enzyme‐linked immunospot method and the flow cytometric analysis on the isolated splenocytes. The results demonstrated that tumor‐bearing mice immunized with Lip/DOPE/MPL/P5 formulation had the most released interferon‐γ and the highest cytotoxic T lymphocyte responses that led to the lowest tumor size and the longest survival time than those of other formulations. The results achieved by Lip/DOPE/MPL/P5 formulation could make it a suitable candidate to induce effective antigen‐specific tumor immunity against breast cancer.
The clinical and prognostic significance of YWHAZ in non‐small–cell lung cancer patients: Immunohistochemical analysis
Authors: Deng Yong , Zheng Jianyun , Ma Jiangang 
Published: October 2018

AbstractYWHAZ has been suggested to as an oncogene in various human malignancies, including non‐small–cell lung cancer (NSCLC). Our study presents more evidence to confirm the clinical significance and biological function of YWHAZ in NSCLC. In our results, YWHAZ was upregulated in lung squamous cell carcinoma tissues and lung adenocarcinoma tissues through analyzing The Cancer Genome Atlas (TCGA) database, and confirmed high levels of YWHAZ messenger RNA and protein in lung squamous cell carcinoma tissues and lung adenocarcinoma tissues through quantitative real‐time polymerase chain reaction and immunohistochemistry. Moreover, YWHAZ overexpression was correlated with advanced clinical stage, more lymph node metastasis and present distant metastasis in NSCLC patients. Survival analysis indicated that high level of YWHAZ protein expression was associated with short overall survival time in NSCLC patients, and YWHAZ expression was independent prognostic factors for overall survival in NSCLC patients. Moreover, Silencing of YWHAZ expression represses NSCLC cell migration and invasion. In conclusion, YWHAZ is a credible prognostic biomarker, and may be a therapeutic target in NSCLC.
Downregulation of miR‐24‐3p promotes osteogenic differentiation of human periodontal ligament stem cells by targeting SMAD family member 5
Authors: Li Zhaobao , Sun Yaru , Cao Sumin , Zhang Jing , Wei Jianming 
Published: October 2018

AbstractOsteogenic differentiation is a complicated process that depends on various regulatory factors and signal pathways. In our research, the osteogenic differentiation capacity was analyzed by alizarin red staining, alkaline phosphatase activity, and protein levels of osteogenic differentiation markers including runt‐related transcription factor 2, bone morphogenetic protein 2, and osteocalcin (OCN). We observed a notable decrease of miR‐24‐3p level in osteogenic‐differentiated human periodontal ligament stem cells (hPDLSCs) by microarray analysis. In our gain‐ and loss‐of‐function experiments, we discovered that miR‐24‐3p has a suppression effect on hPDLSCs osteogenic differentiation. Moreover, SMAD family member 5 (Smad5), the critical osteogenic differentiation transcription factors, was predicted to be targets of miR‐24‐3p. In addition, luciferase reporter assay further proved that miR‐24‐3p directly targeted the 3′‐untranslated region of Smad5. Similarly, we found that the overexpression of miR‐24‐3p significantly decreased the Smad5 messenger RNA level in hPDLSCs, which was detected by real‐time quantitative polymerase chain reaction. Then hPDLSCs were transfected with miR‐24‐3p mimics to inhibit Smad5 expression; meanwhile, Smad5 RNA interference could significantly reverse the osteogenic differentiation inhibition effect of miR‐24‐3p. In brief, a series of data showed that miR‐24‐3p is a regulator of Smad5, playing an important role in osteogenic differentiation.
Protective role of heat shock transcription factor 1 in heart failure: A diagnostic approach
Authors: Haybar Habib , Shahrabi Saeid , Rezaeeyan Hadi , Shirzad Reza , Saki Najmaldin 
Published: October 2018

AbstractObjectiveNonexpression or expression inhibition of protective factors has been determined in the occurrence of heart failure (HF). Heat shock transcription factor 1 (HSF1) is among such factors, which reduces the incidence of HF by controlling cardiac hypertrophy and fibrosis. In this study, molecular mechanisms for nonexpression of HSF1 in HF patients have been investigated.Materials and methodsThis review paper is based on the material obtained via PubMed search of 1996–2018. The key search terms were "heart failure," "heat shock transcription factor 1," "hypertrophy", "fibrosis," and "apoptosis."ResultsAlthough factors such as janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) and heat shock proteins (HSPs) may respectively increase and decrease susceptibility to HF, in some circumstances, these factors may unexpectedly prevent HF progression.ConclusionFinally, identification of molecular pathways expressed by various factors could be used to design appropriate treatments or to employ strategies inducing the expression of HSF1 to prevent HF.