bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diets of denning female Pacific martens vary with the developmental stage of their kits
Authors: Slauson Keith M. , Zielinski William J. 
Published: April 2019

Abstract

Food resources can be a limiting factor and natural and anthropogenic influences that alter the abundance of food resources can affect population performance and persistence. Reproduction in mammals is energetically costly; therefore, understanding how food resources influence reproduction is essential, especially for species of conservation concern.

The objectives of this study were to characterize Pacific marten (Martes caurina) diets during the denning period and determine whether diets differed by sex or by phase of the denning period.

We used 943 scats to reconstruct sex‐specific diets of martens in the Sierra Nevada mountains during the denning period to evaluate sex‐specific hypotheses of predation patterns.

During the lactation phase, females preyed primarily on large‐sized prey (62.5% metabolizeable energy) 5.7‐times more than males. This likely optimized both energy gain and minimized time spent away from dependent young. During the weaning phase, females preyed primarily on medium‐ (90–200 g) and large‐sized prey (87.7% metabolizeable energy). During the predispersal phase, females exhibited a 4.7‐fold increase in use of small‐sized (<50 g) prey during the time kits are learning to hunt.

Male overall diet and predation patterns appear to fit an optimal foraging strategy that is influenced primarily by prey profitability and abundance, with males preying primarily on medium‐sized prey, closest to meeting their lower energetic needs. In contrast, females appear to fit the predictions for a central place forager that is also influenced by prey profitability, but also the increased energetic and maternal demands of denning, leading them to use larger prey than males over the phases of the denning period when kits are growing. We hypothesize that switching to smaller prey is related to females assisting their kits in developing hunting skills and experience that may increase their chances of survival once they disperse.
Sodium–glucose co‐transporter 2 inhibition with empagliflozin improves cardiac function in non‐diabetic rats with left ventricular dysfunction after myocardial infarction
Authors: Yurista Salva R. , Silljé Herman H.W. , Oberdorf‐Maass Silke U. , Schouten Elisabeth‐Maria , Pavez Giani Mario G. , Hillebrands Jan‐Luuk , van Goor Harry , van Veldhuisen Dirk J. , de Boer Rudolf A. , Westenbrink B. Daan 
Published: April 2019

AimsSodium–glucose co‐transporter 2 (SGLT2) inhibition reduces heart failure hospitalizations in patients with diabetes, irrespective of glycaemic control. We examined the effect of SGLT2 inhibition with empagliflozin (EMPA) on cardiac function in non‐diabetic rats with left ventricular (LV) dysfunction after myocardial infarction (MI).Methods and resultsNon‐diabetic male Sprague–Dawley rats underwent permanent coronary artery ligation to induce MI, or sham surgery. Rats received chow containing EMPA that resulted in an average daily intake of 30 mg/kg/day or control chow, starting before surgery (EMPA‐early) or 2 weeks after surgery (EMPA‐late). Cardiac function was assessed using echocardiography and histological and molecular markers of cardiac remodelling and metabolism were assessed in the left ventricle. Renal function was assessed in metabolic cages. EMPA increased urine production by two‐fold without affecting creatinine clearance and serum electrolytes. EMPA did not influence MI size, but LV ejection fraction (LVEF) was significantly higher in the EMPA‐early and EMPA‐late treated MI groups compared to the MI group treated with vehicle (LVEF 54%, 52% and 43%, respectively, all P < 0.05). EMPA also attenuated cardiomyocyte hypertrophy, diminished interstitial fibrosis and reduced myocardial oxidative stress. EMPA treatment reduced mitochondrial DNA damage and stimulated mitochondrial biogenesis, which was associated with the normalization of myocardial uptake and oxidation of glucose and fatty acids. EMPA increased circulating ketone levels as well as myocardial expression of the ketone body transporter and two critical ketogenic enzymes, indicating that myocardial utilization of ketone bodies was increased. Together these metabolic changes were associated with an increase in cardiac ATP production.ConclusionEmpagliflozin favourably affects cardiac function and remodelling in non‐diabetic rats with LV dysfunction after MI, associated with substantial improvements in cardiac metabolism and cardiac ATP production. Importantly, it did so without renal adverse effects. Our data suggest that EMPA might be of benefit in heart failure patients without diabetes.
Expectations influence treatment outcomes in patients with low back pain. A secondary analysis of data from a randomized clinical trial
Authors: Eklund Andreas , De Carvalho Diana , Pagé Isabelle , Wong Arnold , Johansson Melker S. , Pohlman Katherine A. , Hartvigsen Jan , Swain Michael 
Published: April 2019

AbstractBackgroundLow back pain (LBP) is a global public health challenge, which causes high healthcare costs and the highest burden on society in terms of years lived with disability. While patients’ expectations for improvement may have effects on LBP treatment outcomes, it remains unclear if psychological profiles modify this relationship. Therefore, the objectives of this study were to investigate if (a) patients’ expectations predicted short‐term outcome, and (b) psychological profile, pain intensity and self‐rated health modified the relationship between expectations and outcome.MethodsData were collected between April 2012 and January 2016 during the inclusion into a randomized controlled trial. Potentially eligible participants were identified through 40 chiropractic clinics located across Sweden. Patients’ expectations, psychological profile, pain intensity, activity limitation and self‐rated health were collected from patients with recurrent persistent LBP during their first chiropractic visit (n = 593). Subjective improvement was measured at the fourth visit.ResultsPatients with a high expectation of improvement had 58% higher risk to report an improvement at the fourth visit (RR = 1.58, 95% CI: 1.28, 1.95). Controlling for potential confounders only slightly decreased the strength of this association (RR = 1.49, 95% CI: 1.20, 1.86). Baseline pain intensity, psychological profile and self‐rated health did not modify the effect of expectation on outcome.ConclusionsBaseline patients’ expectations play an important role when predicting LBP treatment outcomes. Clinicians should consider and address patients’ expectations at the first visit to best inform prognosis.SignificanceThis study confirms the importance of patients’ expectations in a clinical setting. Patients’ expectations predict the short‐term outcome of chiropractic care for LBP. Pain intensity, psychological profile and self‐rated health did not modify this relationship.
The legacy of cover crops on the soil habitat and ecosystem services in a heavy clay, minimum tillage rotation
Authors: Crotty Felicity V. , Stoate Chris 
Published: April 2019

AbstractCover crops are grown as potential ways to improve soil fertility, soil structure, and biodiversity, while reducing weed/pest burdens. Yet, increased costs (in both time and fuel), farmer knowledge requirements, and yield uncertainty (green bridge effect and variable crop establishment) have led to hesitation among farmers. This study was conducted at the field scale (covering an area of nearly 20 hectares) to determine whether different cover crop mixtures affected soil properties and ecosystem services on a heavy clay soil. Measurements of soil chemistry, physics, biology, weed abundance, and subsequent crop performance were taken within a minimum tillage management system, across three cover crop mixtures (commonly sold to UK farmers). The cover crop mixtures included oats (Avena sativa), radish (Raphanus sativus), phacelia (Phacelia tanacetifolia), vetch (Vicia sativa), legumes, buckwheat (Fagopyrum esculentum) and a bare stubble control followed by a spring oat crop. Soil physics (penetrometer and bulk density) and chemistry (N, P, K, Mg, Ca, and organic matter) varied little across treatments, although there was significantly lower Mg in the cover crop including legumes and an increase in NO3 within this treatment. Soil biology and botanical composition were also assessed, monitoring earthworm and mesofauna abundance; and sown and unsown (weed) biomass. Epigeic earthworms were found to have significantly larger abundance in cover crop mixtures with radish present, although other meso‐ and macrofauna did not differ. Significant weed suppression was found during both the cover crop growing period and as a legacy in the subsequent crop, leading to significant yield increases and economic benefits in some treatments. Our study confirms that cover crops are providing benefits, even on heavy clay soils, including improvements in nutrient leaching risk reduction, weed suppression, and crop yield, coupled with wider ecosystem benefits. We therefore consider cover crops to have a role in sustainable management of arable rotations.
The improvement of cell infiltration in an electrospun scaffold with multiple synthetic biodegradable polymers using sacrificial PEO microparticles
Authors: Hodge Jacob , Quint Clay 
Published: April 2019

AbstractElectrospinning is a fabrication technique to generate three dimensional scaffolds with a fiber structure that imitates extracellular matrix for tissue engineering constructs. The versatile characteristics of the electrospinning process yields designer scaffolds made of biodegradable polymers or natural proteins with controllable fiber diameters, biodegradation, and mechanical properties. A limitation of conventional electrospun scaffolds is the dense fiber packing with low porosity that leads to poor cell infiltration. Electrospraying sacrificial polyethylene oxide (PEO) microparticles in combination with electrospun scaffolds are a method to increase porosity. We report the effectiveness of electrospraying PEO microparticles to increase porosity of the most commonly used biodegradable polymers: polyglycolic acid (PGA), poly (lactic‐co‐glycolic) acid (PLGA), and polycaprolactone (PCL). The biodegradable polymer electrospun scaffolds with the sacrificial PEO microparticles were found to have improved cell proliferation and infiltration with human fibroblasts compared to conventional electrospun scaffolds. The mechanical properties of the more robust PGA and PLGA had minor changes, but the more elastic PCL was observed to be weaker and less stiff after the removal of the PEO microparticles. Therefore, this study found PEO microparticles can increase porosity and cell infiltration with stable mechanical properties for a wide variety of biodegradable polymers in electrospun scaffolds.
Decreased expression of FcγRII in active Graves' disease patients
Authors: Lu Xixuan , Peng Shiqiao , Wang Xinyi , Shan Zhongyan , Teng Weiping 
Published: April 2019

AbstractBackgroundGraves' disease (GD) is a common autoimmune disease characterized by genetic and environmental factors. Fcγ receptors (FcγRs) are involved in several autoimmune disorders through recognizing immunoglobulin (Ig) G antibodies and mediating immune response. The study on the expression of FcγRs in GD patients is scarce. The purpose of this study was to evaluate the expression of three different types of FcγRs in patients with active and remissive GD.MethodsBlood samples of patients and healthy subjects were collected to analyze the percentage of FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16) on peripheral blood mononuclear cells (PBMCs) and monocytes by flow cytometry and Western blotting. CD32 isotypes were also examined in cases and controls by real‐time PCR.ResultsThe cell percentages expressed CD32 and protein expressions of CD32 on PBMCs, and monocytes from patients with active GD were significantly reduced compared to controls and patients with remissive GD. In particular, the expression of CD32B on PBMC was also decreased in active GD patients. However, the cell percentages expressed CD16 and CD64 from PBMCs and monocytes were comparable between three groups. Besides, the percentages of CD14+CD32+ cells were negatively correlated with TRAb titers in active GD patients (r = −0.5825, P ＜ 0.001).ConclusionThese results suggested that CD32 may act as a novel marker for active GDs. The expression of monocytic CD32, in particular CD32B, in GD patients might play a crucial role in maintaining FcγRs function and be a therapeutic target in GD patients.
Biologging subcutaneous temperatures to detect orientation to solar radiation remotely in savanna antelope
Authors: Botha Arista , Lease Hilary M. , Fuller Andrea , Mitchell Duncan , Hetem Robyn S. 
Published: April 2019

AbstractObservations of animal thermoregulatory behavior are labor‐intensive, and human presence may disturb the normal behavior of the animal. Therefore, we investigated whether a remote biologging technique could be used to detect orientation to solar radiation in savanna antelope. We predicted that when a mammal was orientated perpendicular to solar radiation, the subcutaneous temperature on the side of the body facing the sun would be greater than that on the opposite side, whereas when the mammal was orientated parallel to solar radiation, subcutaneous temperatures on both sides would be similar. A pilot study showed that the difference between left‐ and right‐side temperatures under a pelt reflected orientation to solar radiation if a pelt‐covered cylinder had been orientated for 15 min or longer. In addition, the rate of change in temperature difference could detect orientation that had changed within the previous 5 min. We implanted temperature‐sensitive data loggers subcutaneously into the flanks of eight black (Connochaetes gnu) and eight blue (Connochaetes taurinus) wildebeest. By incorporating both the rate of change and subcutaneous temperature differences and excluding times when wildebeest were lying down, our predictions correctly matched behavioral observations of wildebeest orientation to solar radiation 71% of the time. Our technique tended to fail when wildebeest were lying down, wind speeds were high and the sun was overhead. But those are conditions in which the benefits of manipulating orientation to solar radiation is of diminishing importance to a free‐living mammal. Therefore, subcutaneous temperatures provide physiologically relevant information on the importance of solar radiation to mammals.
Genome‐wide comparison of codon usage dynamics in mitochondrial genes across different species of amphibian genus Bombina
Authors: Barbhuiya Parvin A. , Uddin Arif , Chakraborty Supriyo 
Published: April 2019

AbstractThe biological phenomenon where some synonymous codons are repeatedly preferred to others in gene transcripts is called codon usage bias (CUB). The analysis of CUB is not only helpful in evolutionary biology but also in improving the expression level of exogenous genes in the host cell by codon optimization. The overall nucleotide composition analysis demonstrated an unequal distribution of four nucleobases and T% was the highest in all seven species. The genes were AT‐rich, evident from overall low GC content. In addition, third codon position analysis indicated that in four Bombina species namely, Bombina fortinuptialis, Bombina lichuanensis, Bombina maxima, Bombina microdeladigitora, nucleobase A3/T3 was the preferred one, whereas A3/C3 was favored in Bombina bombina, Bombina orientalis, and Bombina variegata. Influence of mutation pressure on codon distribution and codon bias was evident from correlation analysis. Correspondence analysis demonstrated that compositional bias driven by mutation pressure along with natural selection acted on CUB of mitochondrial genes. Neutrality plot revealed that natural selection played a major role whereas mutation pressure had a minor but significant role. Our phylogenetic analyses showed that closely linked species belonging to the same genus were noticeably separated in different clades.
Clostridium butyricum Strains Suppress Experimental Acute Pancreatitis by Maintaining Intestinal Homeostasis
Authors: Pan Li‐Long , Niu Wenying , Fang Xin , Liang Wenjie , Li Hongli , Chen Wei , Zhang Hao , Bhatia Madhav , Sun Jia 
Published: April 2019

ScopeAcute pancreatitis (AP) is a common abdominal inflammatory disease. Disturbed gut homeostasis secondary to pancreatic inflammation aggravates the condition retroactively. The current study investigates potential beneficial effects of Clostridium butyricum (C. butyricum) strains on AP and underlying mechanisms.Methods and resultsC. butyricum strains MIYAIRI 588 (CBM588) and CGMCC0313.1 (CB0313.1) were supplemented to mice for three weeks before experimental AP or SAP induction. Both CBM588 and CB0313.1 protected against AP, as evidenced by reduced serum amylase and lipase levels, pancreatic edema, and myeloperoxidase activity. Amelioration of both experimental AP and SAP by CB0313.1 indicated a non‐model‐specific effect. Moreover, C. butyricum inhibited pancreatic neutrophil and dendritic cell infiltration, nucleotide‐binding domain leucine‐rich repeat‐containing family, pyrin domain‐containing 3 inflammasome activation, and pro‐inflammatory pathways. Additionally in the gut, C. butyricum strains attenuated AP‐associated intestinal inflammation and barrier dysfunction, accompanied with reduced pathogenic bacteria Escherichia coli and Enterococcus penetration into pancreas. Gut microbiome analyses further revealed that beneficial effects of C. butyricum on pancreatic‐gut homeostasis were correlated with improved dysbiosis. In particular, relative abundance of Desulfovibrionaceae decreased, and Verrucomicrobiaceae Clostridiaceae and Lactobacillaceae increased.ConclusionsFor the first time, a protective effect of C. butyricum in AP by modulating intestinal homeostasis is demonstrated.
The RitualThiyóšpayeand the Social Organization of Contemporary Lakota Ceremonial Life
Authors: Posthumus David C. 
Published: April 2019

AbstractThis paper examines continuity and change in Lakota belief and ritual, focusing on the social organization of contemporary Lakota ceremonial life. For many Lakotas of Pine Ridge Reservation ritual structures life. The contemporary religious landscape consists of a number of ritual groups, which I call ritualthiyóšpayes, after the Lakota word for band or lodge group, the extended family and historical basic unit of kinship. At the center of these groups is a religious practitioner, a symbol of group identity and solidarity. Ritualthiyóšpayes consist of core and sub‐core member families that regularly attend rituals and other corporately sponsored social events. The cohesion of a ritualthiyóšpayeis based largely on equality, mutual help, participation, and one‐mindedness. The relationship between a practitioner and his ritualthiyóšpayeis dynamic, characterized by reciprocity, mutual influence, and exchange: the practitioner shapes the beliefs, worldview, and identity of his followers, symbolizing the group to both members and nonmembers, while simultaneously being shaped by his followers as a representative of their social, psychological, and religious needs, beliefs, and values. Although patterns of social interaction have changed since the dawn of the reservation period, there remains a distinct and undeniable continuity with past traditions.
Urban ecosystems: A new frontier for payments for ecosystem services
Authors: Richards Daniel R. , Thompson Benjamin S. 
Published: April 2019

Abstract

Urban ecosystems provide many benefits to people, including regulation of environmental conditions, recreational opportunities, and positive health impacts. However, many urban ecosystems are under pressure from increasing urbanisation, because the economic benefits they provide are rarely captured by the people who own and manage them. Such ecosystems are seldom economically competitive compared to more profitable residential, commercial, and industrial land uses.

To develop more sustainable cities, we require new approaches for encouraging and enabling interventions that maintain, improve and create urban ecosystems. Payments for ecosystem services (PES) schemes are increasingly used to incentivise conservation and changes in environmental management in rural settings, but this approach has rarely been considered in cities. Here, we explain how payments for urban ecosystem services (PUES) could help protect, restore, and manage urban ecosystems.

To implement PUES, we must understand the differences between various public and private actors who could potentially provide or benefit from urban ecosystem services. For example, utilities companies could pay for reduced water treatment costs via deculverting streams, homeowners could pay for improved stormwater management via increasing permeable surface area, and business proprietors could pay for street tree installation and maintenance to provide shade and reduce air conditioning costs.

Urban densities, land values, and land tenure will impact the types of PUES projects that are most likely to be viable. To be successful, PUES will require an improved understanding of urban ecosystem service science—particularly how service provision changes under different land management practices.

Nevertheless, because of the high densities, co‐location, and wide variety of stakeholders that live in cities, there is potential for PUES to become an innovative funding source to support future urban ecosystem management.

A plain language summary is available for this article.
Mechanical properties of UV‐curable carbon fiber‐reinforced polymer composite patch: Repair evaluation of damaged aluminum alloy
Authors: He Yannan , Liu Xiaoyan , Yu Zhiqiang 
Published: April 2019

Epoxy resin composite patches reinforced by carbon fiber were prepared through ultraviolet (UV)–curing method, and the damaged aluminum alloy plates are rapidly repaired by means of adhesively bonding method. Mechanical properties of the composite patches and damaged aluminum alloy plates before and after repair were studied by experiment and numerical simulation. Results indicated that the tensile properties of carbon fiber/epoxy resin composite patches presented the tendency of first increase and then decrease with the increase of layer numbers of reinforced fiber. The composite patches with two layers fiber showed the best tensile properties, and the tensile strength and modulus reached 1.13 GPa and 27.79 GPa, respectively. However, the bending strength of composite patches decreased with the increase of layer numbers. Results of performance evaluation on the mechanical properties of damaged aluminum alloy plates repaired by the two layers carbon fiber/epoxy resin composite patches showed that the repair efficiency of tensile and bending properties of the repaired aluminum alloys reached more than 83% and 160%, respectively, compared with the undamaged aluminum alloys. Besides, results of numerical simulation showed that the stress intensity factor (SIF) of the crack tip on repaired aluminum alloy plates decreased significantly in comparison with the unrepaired aluminum alloy plates, which further revealing the reinforced mechanism of composite patches on the bending properties of repaired aluminum alloy plates.