bluuebunny/crossref_metadata_2025_split huggingface dataset:
Helyzetkép az elvándorlásban érintett orvosi szakterületek hazai humánerőforrás-ellátottságáról
Authors: Kovács Eszter , Girasek Edmond , Kozák Anna , Sziklai Márta , Bélteki Zsolt , György Annamária , Páva Hanna , Szócska Miklós 
Published: July 2019

Abstract: Introduction: The Human Resources for Health (HRH) mobility and migration are considered as global phenomena. The European Union often faces the mobility of health professionals on a system level. Hungary is recognised among the sending countries, therefore both international and national level health workforce monitoring, planning, and forecasting are inevitable. Aim: The purpose of this research was to investigate the national demographical profiles of the medical professions affected most significantly by the Hungarian HRH mobility process. Method: Age and regional distribution analyses of the requests for degree certificate issued by the National Healthcare Services Centre were carried out between the years of 2010 and 2017. Results: In Hungary, the rate of mobility – the number of requests for degree certificate among the licensed to practice professionals – resulted in the following: the highest rate was detected in anaesthesiology and intensive therapy with 23.5%, in surgery 17.9%, then internal medicine 7.9%, paediatrics 7.4%, and in general practice 6.4%. According to the results, in the 5 above mentioned professions, the physicians most affected by mobility are mostly from the age cohort of 50+. Furthermore, the results also highlight the territorial inequalities: the region of the capital as well as the medical university towns and counties are in the most favourable situation in terms of professional care and supply. Conclusion: Therefore, it can be concluded that in the case of the 5 investigated subspecialties, not only the overall age of the physicians is higher in the disadvantaged areas, but these regions also have to face a more severe shortage of specialists. Orv Hetil. 2019; 160(31): 1223–1230.
Laryngokeleeseteink műtéti megoldásai
Authors: Kiricsi Ágnes , Fazekas Piroska , Nagy Attila , Tóbiás Zoltán , Bella Zsolt , Rovó László , Csanády Miklós 
Published: July 2019

Abstract: Laryngocele is a unilateral or bilateral dilation of the saccule or appendix of the laryngeal ventricle. It is a benign lesion, often without any specific symptom, diagnosed unintentionally, but it can cause life-threatening airway obstruction, needing emergency tracheotomy. The authors present three cases of laryngocele and the related surgical methods. Orv Hetil. 2019; 160(31): 1235–1240.
HeRO (Hemodialysis Reliable Outflow) graft alkalmazása tartós hemodialíziskezelés során
Authors: Legeza Péter , Garbaisz Dávid , Szeberin Zoltán , Sótonyi Péter 
Published: July 2019

Abstract: Creating durable vascular access has become more complicated with the improvement of the management and with the increasing survival of patients with end-stage renal disease. HeRO (Hemodialysis Reliable Outflow) graft allows to maintain vascular access on the upper limb in patients with the presence of bilateral central venous occlusion. Our institute was the first in Hungary to perform a HeRO graft implantation in a patient receiving regular hemodialysis. Our objective was to present our findings with this recent innovation. Case report, medical documentation and imaging studies were reviewed. The patient (73-year-old, female) has been receiving hemodialysis since 12 years with the history of several arteriovenous fistula (AVF) creations, thrombectomies, use of central venous catheter in both sides. Following the occlusion of a left cubital arterio-venous fistula, none of the conventional vascular access types could have been performed due to bilateral subclavian vein occlusion. Successful HeRO graft implantation was performed. The patient underwent graft thrombectomy and endovascular intervention 7 and 12 months after the original procedure. After both reoperations, the graft functioned well for hemodialysis. HeRO graft can be a good alternative to central venous catheters and lower limb arterio-venous grafts in cases of bilateral central venous occlusion. Orv Hetil. 2019; 160(31): 1231–1234.
Cochlearis implantátumok különböző, előre görbített elektródasorainak elhelyezkedése a cochlea tengelyéhez viszonyítva. Radiológiai vizsgálat a perimodiolaritás mértékének megállapítására
Authors: Perényi Ádám , Nagy Roland , Dimák Balázs , Csanády Miklós , Jóri József , Kiss József Géza , Rovó László 
Published: July 2019

Abstract: Introduction: The cochlear implants vary in electrodes in terms of length, width and proximity to the modiolus. The precurved electrode arrays could be placed closer to the modiolus and the ganglion cells compared to straight electrodes. The two types of electrode arrays provide different electrophysiological characteristics; however, proximity to the modiolus may lead to better hearing performance. Aim: To investigate our preliminary electrophysiological results that suggest that the Slim Modiolar (SM) electrode array has the potential to elicit similar neural responses as the thicker perimodiolar (Contour Advance, CA) electrode from the same generation of implants. Method: Subjects that were implanted either with CA or SM electrodes were enrolled, 54 consecutive subjects in each group. All electrodes were introduced into the cochlea via the round window. The diameter of the largest turn of the electrode arrays within the cochlea was measured through postoperative radiography. The energy consumption parameters were estimated 2 months after implantation. Results: The mean of the largest turns of the arrays within the cochlea was 4.2 ± 0.5 mm in the SM group and 4.9 ± 1.1 mm in the CA group. ‘Auto power’ was 44.81 ± 5.05% and 50.85 ± 8.35% with SM and CA, respectively. Estimated energy consumption was lower with SM. The differences were statistically significant. Conclusion: Our measurements for a large cohort in each group suggest that the SM electrode array takes a significantly closer position to the modiolus than the CA. This finding supports our earlier electrophysiological result and indicates better performance abilities. Orv Hetil. 2019; 160(31): 1216–1222.
Az antihyperglykaemiás terápia deeszkalációja 2-es típusú diabetesben – amikor a kevesebb több
Authors: Jermendy György 
Published: July 2019

Abstract: Type 2 diabetes – due to its natural course – should be considered as a progressive chronic disease. Owing to this fact, antihyperglycemic treatment should be continuously increased stepwise in order to achieve proper glycemic control. Lifestyle modification should be initiated immediately after manifestation, shortly followed by metformin monotherapy, and later, dual or triple combinations and, finally, injectable derivatives – only insulin in the past – should be used for appropriate glycemic control. Guidelines about treatment approach of patients with type 2 diabetes unequivocally emphasize and describe in detail the need of treatment intensification, in other words, stepwise escalation in clinical practice. In the last couple of years, evidences provided that step down therapy, simplification of complex treatment regimens should also be considered in certain cases. This approach was generally called de-escalation in antihyperglycemic treatment which should be considered in patients with type 2 diabetes 1) after bariatric (metabolic) surgery; 2) with significant weight reduction irrespective of its origin; 3) with complex insulin regimens where re-evaluation of this treatment was missed; 4) with continuously decreasing renal function; 5) among elderly patients with comorbidities; 6) in social deprivation. In this article, data about therapeutic de-escalation of antihyperglycemic treatment in patients with type 2 diabetes and first experiences with this treatment approach are summarized. Orv Hetil. 2019; 160(31): 1207–1215.
Asynchronous replication of AURKA and TP53 genes in gastric cancer patients and patients with multiple tumors
Authors: Tsepenko V. V. , Mikhailova G. F. , Shkavrova T. G. , Goloub E. V. , Rukhadze G. O. , Skoropad V. Yu. 
Published: July 2019

Background. The correct genome replication is essential for normal cell division to guarantee that genetic information comes changeless through the next cells generations. DNA replication is a strictly regulated and synchronous process and its disturbances could result to mutations appearances. Aberrant time of DNA replication affects on gene expression causes changes of epigenetic modifications and influences on increasing the structural rearrangements leading to enhanced genome disbalance. Replication time failure as asynchronous replication is common for cancerogeneses. The objective of our study was the assessment of asynchronous replication levels in patients with gastric cancer and patients with multiple tumors.Materials and methods. Fluorescence in situ hybridization (FISH) was used for the asynchronous replication of AURKA and TP53 genes analyses. Interphase FISH on lymphocytes of peripheral blood of 37 healthy donors, 19 patients with non-cancer gastrointestinal pathologies, 68 patients with solitary gastric cancer and 39 patients with multiple tumors having gastric cancer and other second synchronous or metachronous tumor was carried out.Results. Values of lymphocytes with asynchronous replication for AURKA were 19.8 ± 0.5 % for control group, 24.7 ± 0.4 % for non-cancer patients, 32.5 ± 0.5 % for gastric cancer patients, 39.5 ± 0.6 % for patients with multiple tumors and 17.3 ± 0.5, 19.5 ± 0.7, 26.1 ± 0.7 and 32.5 ± 0.6 % for TP53 respectively. Differences between cell populations of examined groups had statistical significance with p <0.01 for both studied gene. Also there was statistical difference between gastric cancer patients having distant metastases and gastric cancer patients without metastases for AURKA (34.4 ± 1.0 % vs. 31.7 ± 0.6 %; p = 0.02).Conclusion. High lymphocytes with asynchronous replication level in oncological patients could serve as potential marker of second tumor or possible metastatic process including the earliest stage of it.
The prognostic significance of BRCA1 gene expression in patients with breast cancer
Authors: Tsyganov M. M. , Ibragimova M. K. , Pevzner A. M. , Garbukov E. Yu. , Slonimskaya E. M. , Litviakov N. V. 
Published: July 2019

Background. Nowadays, BRCA-associated breast cancer occupies a special position in the choice of treatment strategy. Although, the drug treatment of such patients was almost the same as the treatment of sporadic disease. Of particular interest is the assessment of the deficit of homologous recombination, which may include various dysfunctions of the BRCA1 gene. Moreover, it has been shown that a decrease in the functional activity of BRCA1 is reflected in the sensitivity of the tumor to DNA damaging agents, and the prognosis of the disease becomes more favorable.Objective: assessment of the association of BRCA1 gene expression in a breast tumor with the prognosis of the disease.Materials and methods. The study included 111 patients with breast cancer T1–4N0–3M0 (stage IIA–IIIB), with a morphologically verified diagnosis. Initial and postoperative expression of BRCA1 in tumor material was evaluated. RNA was isolated from the tumor material before treatment and after neoadjuvant chemotherapy. The level of BRCA1 expression was assessed using reverse transcriptase quantitative real-time polymerase chain reaction.Results. As a result of the study, long-term results of treatment of patients were evaluated depending on the level of BRCA1 gene expression. The presence of BRCA1 hypoexpression (level less than 1) in tumor tissue after neoadjuvant chemotherapy was found to be a favorable prognostic factor and is associated with high rates of metastasis-free survival (p = 0.0002). In addition, a similar result is shown for patients treated with the FAC (fluorouracil, doxorubicin, cyclophosphamide) neoadjuvant chemotherapy regimen (p = 0.005). Despite the absence of statistically significant differences, in 8 patients who underwent chemotherapy with the inclusion of platinum drugs, there was a low level of BRCA1 expression in a residual tumor and 100 % non-metastatic and overall survival.Conclusion. Based on the data obtained, it can be assumed that the aberrant state of the BRCA1 gene (low expression) in a breast tumor may also be a promising marker for the prognosis of the disease, which confirms the undoubted relevance of the study, but also requires further detailed study.
Funkcje podatków w doktrynie prawnofinansowej oraz ich znaczenie dla praktyki stanowienia prawa podatkowego
Authors: Zieliński Robert 
Published: August 2019

Przedmiotem niniejszego artykułu jest charakterystyka funkcji, jakie w doktrynie prawnofinansowej realizują podatki oraz wskazanie ich znaczenia dla praktyki stanowienia prawa podatkowego. W pierwszej kolejności zwrócono uwagę na trudności dotyczące zdefiniowania pojęcia funkcji podatków oraz na brak ich jednolitego katalogu w doktrynie prawa finansowego. Następnie przedstawiona została fiskalna funkcja podatków, a w dalszej kolejności dokonano omówienia pozafiskalnych celów realizowanych przez te daniny publiczne, w głównej mierze scharakteryzowana została ich funkcja redystrybucyjna oraz stymulacyjna.
W niniejszym opracowaniu wskazano, że pomimo, iż podstawową funkcją podatków jest funkcja fiskalna, to nie wszystkie podatki realizują ją w takim samym stopniu. W szczególności pierwszoplanowego znaczenia fiskalnego nie powinny odgrywać podatki obciążające dochody osobiste obywateli, gdyż z uwagi na ich konstrukcję prawną są daninami publicznymi predestynowanymi do realizacji zadań o charakterze rozdzielczym i społecznym (socjalnym). Konstatacja ta stanowi, jak się wydaje, istotną wskazówkę dla praktyki stanowienia prawa podatkowego.
PENGEMBARAAN AKUNTAN MENUJU KESADARAN SPIRITUAL: DILIHAT DARI PERSPEKTIF ONTOLOGI, EPISTEMOLOGI, DAN AKSIOLOGI
Authors: Leniwati Driana 
Published: July 2019

<p class="MateriArtikel"><em>Modern accounting that emphasizes material and value-free makes accounting toward materialistic, selfish, secularistic and</em><em> </em><em>atheistic. This is </em><em>proven</em><em> by the many cases of irregularities and manipulations of financial statements carried out by accountants that reflect </em><em>those</em><em> characteristics. </em><em>Meanwhile</em><em> human assumptions as an opportunistic, greedy and selfish homo economicus increasing</em><em> this phenomenon. </em><em>Th</em><em>is become the big </em><em>question</em><em> to </em><em>accountin</em><em>g science </em><em>and the nature of accountants. Accounting as a branch of science has </em><em>far away from the</em><em> philosophy.</em><em> T</em><em>he foothold of the science of accounting </em><em>is </em><em>to achieve the true nature of science </em><em>and</em><em> attain the ultimate truth of science. This study aims to review accounting from the perspective of ontology, epistemology, axiology and synergize the self-awareness of accountants in relation to humans, nature and God will bring accounting knowledge back to its essence and accountant to God so that accounting science will </em><em>give </em><em>benefit </em><em>to </em><em>humanity. </em></p>
ЛИНГВОКУЛТУРОЛОШКИ СТАТУС ЛЕКСЕМЕ КАМЕН
Authors: Штрбац Гордана 
Published: August 2019

У раду се испитује језичка слика природе тако што се анализом одговарајућих номинационих јединица покушава описати начин на који говорни представници српског језика сагледавају своје природно окружење. За ово истраживање одабрана је лексема камен. На основу речничких података описано је њено лексикографско и психолингвистичко значење и разматрани су устаљени изрази и фразеологизми у чији састав улази дата лексема. Њихова анализа потврдила је полазну претпоставку да поменута номинациона средства одражавају основне когнитивне механизме, као и симболичке, архетипске и друге елементе културе.
SOCIALIZATION OF SELF CARE TOGA AND ACUPRESSURE AT GADING HEALTH CENTER IN SURABAYA
Authors: Imandiri Ario , Septriana Maya 
Published: August 2019

Background: The community made various efforts to be able to overcome the health complaints that they experienced, whether it was done alone by people who experienced health complaints or by healthy families. Efforts made by the community in overcoming health complaints suffered include self-treatment based on the knowledge they have by massage or consuming materials or processed from plants or animals, conducting consultations or examinations on traditional and medical health facilities, and can also bring in officers home health. Purpose: Increasing public knowledge regarding how to process traditional medicines and independent acupressure. Method: Providing knowledge to the Independent Care Cadres of Gading Surabaya Health Center regarding how to process traditional medicines and independent acupressure through demonstration of making traditional medicines and independent acupressure. Results: The activity of Independent Care of Family Medication and Acupressure Care for Cadre groups in Gading Surabaya Health Center went well. The cadre welcomed the program and they participated in the coaching activities actively. Conclusion: The Independent Care of Family Medication and Acupressure care for Cadre groups coaching program in Gading Surabaya Health Center is very beneficial for the community in overcoming minor ailments without taking chemical drugs.
Respon Pertumbuhan dan Hasil Sawi Pagoda (<em>Brassica Narinosa</em>) terhadap Pemberian Mol Daun Kelor
Authors: Suhastyo Arum Asriyanti , Raditya Fanny Tri 
Published: July 2019

The use of liquid fertilizers by utilizing local types of microorganisms (MOL) can be an alternative to supporting nutrient requirements in the soil, and it can be a solution to environmentally friendly agriculture and free from fertilizers and chemical pesticides. Moringa leaves contain chemical compounds such as calcium, magnesium, phosphorus, iron and sufur so that the leaves of Moringa can be used to make liquid organic fertilizer. In this study, the effect of MOL leaves on the growth and yield of mustard pagoda plants was evaluated. The research was design by factorial randomized block design, with two factors The first factor was dosage of MOL Moringa leaves: 0, 50, 60, and 70 mL L<sup>-1</sup>. The second was frequency of MOL Moringa leaves application: periodically every 5, 6, and 7 days, Each treatment was repeated 3 times to obtain 36 experimental plots. To find out the response observed to the given treatment, Variance Analysis Test (ANOVA) was carried out and if it showed a significant difference, continued with Duncan's Multiple Ranged Test. The results showed the frequency and concentration of MOL leaves of Moringa leaves could increase plant height in the treatment frequency of 6 days given 70 ml / l MOL Moringa leaves which was 4,89 cm and the frequency, concentration of MOL leaves of moringa and their interactions had not been able to increase the number of leaves and the fresh weight of the pagoda mustard plant.
Pengaruh Pupuk Organik dan Jarak Tanam terhadap C-Organik, Populasi Jamur Tanah dan Bobot Kering Akar serta Hasil Padi Sawah pada Inceptisols Jatinangor, Sumedang
Authors: Adviany Ida , Maulana Dick Dick 
Published: July 2019

<p>This experiment was conducted to study the effect of organic fertilizer and plant spacing on organic-C, soil fungi population, dried weight root and rice yield (<em>Oryza sativa</em> L.) grown on Inceptisols Jatinangor. This experiment was arranged in split plot design, consisted of two factors with 12 treatments and three replications. The first factor as main plot was organic fertilizer, which dosage of 0, 200, 400 and 600 kg ha<sup>-1</sup> respectively. The second factor as sub plot was plant spacing, which of 25 cm x 25 cm , 30 cm x 30 cm and 35 cm x 35 cm, respectively. The result of experiment showed that there were no interaction effect between organic fertilizer and plant spacing on organic-C, soil fungi population, root dry weight and rice yields. The main effect of plant spacing treatment gave significantly effected on dried weight of root and rice yields per plot and per 10 stool. The highest rice yield per plot, 9.276 kg plot<sup>-1 </sup>(4.638 t ha<sup>-1</sup>)was achieved from plants with spacing 25 cm x 25 cm and the highest rice yield per 10 stools was 747 g from plants with spacing.35 cm x 35 cm.</p>
Pengaruh Biochar terhadap Pertumbuhan Padi dalam Sistem Aerobik
Authors: Suswana Suli 
Published: July 2019

<p>An application of biochar to the intensive weathered soils potentially can change physical and chemical properties of the soils, improved soil function and increased yield of crops. A meta-analyses evaluation showed a significant correlation between biochar and plants productivity, that means there are benefits of biochar application to the soils on plants productivities, that was increased 10%.This experiment was used Randomized Completed Block Design with 8 treatments and 3 replications. The treatments are: contr), 20 ton biochar ha<sup>-1</sup>, 40 ton biochar ha<sup>-1</sup>, 50 ton biochar ha<sup>-1</sup>, 60 ton biochar ha<sup>-1</sup>, 10 ton biochar + 10 ton poultry litter ha<sup>-1</sup>, 20 ton biochar + 20 ton poultry litter ha<sup>-1</sup>, 30 ton biochar + 30 ton poultry litter ha<sup>-1</sup>. The results showed biochar 20 ton ha<sup>-1</sup> could increase significantly of plant heigh, number of punicles per clump, and the weight dried straw per clump. Whereas, application combination 20-30 ton biochar ha<sup>-1</sup> + 20-30 ton poultry litter ha<sup>-1</sup> could increase amount of tillers per clump, amound of punicles per clump, and weight dried straw (total biomass) per clump significantly.</p>
Effectiveness of Liu Zi Jue Qigong versus traditional core stability training for patients with post-stroke complicated with abnormal trunk postural control: a study protocol for a single-center randomized controlled trial
Authors: chen wang , Yu Long , Yang Jian , Wang Ren Wei , Zheng Ya Nan , Zhang Ying 
Published: August 2019

Abstract
Background: Trunk function in stroke patients with hemiplegia is associated with respiration and core stability, and is also found to be associated with balance and postural control and daily activity of life. Liuzijue Qigong (LQG) is a traditional Chinese method of fitness based on breath pronunciation. The purpose of this study is to compare the clinical efficacy of LQG and traditional core stability training in the treatment of stroke patients with abnormal trunk posture. This protocol is written according to the SPIRT 2013 Statement.
Methods: This study is a single-center randomized controlled trial in which 160 stroke patients are randomly divided into study group and control group. Patients in the study group will receive LQG combined with conventional rehabilitation therapy, while patients in the control group will receive traditional core stability training combined with conventional rehabilitation therapy. All treatments will be treated 45 minutes a day, 5 times a week for 2 weeks. Primary outcome (Trunk impairment scale) and secondary outcome (Berg balance scale, Fugl-Meyer assessment, Modified barthel index, Maximum phonation time, Dynamic and Static Balance Testing and The thickness and the Mobile degrees of diaphragm) will be conducted at baseline, 2 weeks at the end of the rehabilitation course.
Discussion: The aim of this research is to compare the clinical efficacy of LQG and traditional core stability exercise in the treatment of stroke patients with abnormal trunk posture.
Trial registration: Chinese Clinical Trial Registry: ChiCTR1800014864. Registrated on 10 February 2018, http://www.chictr.org.cn/edit.aspxpid=25313&htm=4.
Keywords: Six character formula, Trunk postural control, Stroke, Core stability, Traditional core stability training, Liuzijue qigong (LQG)