bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary carcinosarcoma of the ureteropelvic junction associated with ureteral duplication
Authors: Tsuji Kentaro , Ito Atsushi , Kurokawa Shinsuke , Nakaya Takeo , Yoshimoto Taichiro , Kawata Hirotoshi , Tamba-Sakaguchi Mio , Fukushima Noriyoshi , Oshiro Hisashi 
Published: August 2019

Abstract

Rationale:
Primary carcinosarcoma of the upper urinary tract is rare. Ureteral duplication is one of the most common urinary tract malformations. Additionally, the association between ureteral duplication and malignancy is unknown. To the best of our knowledge, no cases of malignant tumors diagnosed as carcinosarcoma with ureteral duplication have been reported. We herein report the case of a patient with carcinosarcoma of the ureteropelvic junction associated with incomplete ureteral duplication.

Patient concerns:
A 60-year-old Japanese woman presented with painless gross hematuria. She had a history of total hysterectomy and chemotherapy for endometrioid carcinoma 5 years before. She had no history of occupational chemical exposure.

Diagnoses:
Radiographic imaging revealed right incomplete ureteral duplication, hydronephrosis, and a polypoid tumor in the ureteropelvic junction of the lower moiety of the right kidney. Urine cytology showed a small amount of degenerated atypical epithelial and nonepithelial cells. The transureteral biopsy specimen showed dysplastic urothelial cells and atypical myoid spindle cells. These findings were indefinite for malignancy.

Interventions:
The patient underwent right nephroureterectomy. Pathological examination of the resected tumor showed a biphasic neoplasm composed of carcinomatous and sarcomatous components. The sarcomatous component was immunohistochemically positive for vimentin, desmin, h-caldesmon, and α-SMA and negative for pancytokeratin (AE1/AE3), low molecular weight cytokeratin (CAM 5.2), EMA, E-cadherin, GATA3, uroplakin 2, and p63. Based on these findings, we diagnosed the tumor as carcinosarcoma.

Outcomes:
The postoperative course was uneventful. No additional therapy was administered. The patient has remained alive without recurrence for 21 months since surgery.

Lessons:
Carcinosarcoma can arise from ureteral duplication. Although the majority of carcinosarcomas of the upper urinary tract are diagnosed at an advanced stage and have a poor prognosis, some can have a less aggressive course. Further studies are needed to determine the association between ureteral duplication and malignancy.
Laparoscopic donor right hepatectomy in a donor with type III portal vein anomaly
Authors: Song Jiu-Lin , Wu Hong , Yang Jia-Yin 
Published: August 2019

Abstract

Rationale:
Laparoscopic right donor hepatectomy has been reported sporadically in several experienced centers for selected donors. This report introduced a case of a donor with an independent right posterior segmental portal branching from the main portal vein.

Patient concerns:
A 47-year-old woman volunteered to donate her right liver to her 48-year-old husband.

Diagnoses:
The recipient has been diagnosed as hepatocellular carcinoma meeting the Milan criteria and hepatitis B virus related cirrhosis.

Interventions:
The parenchymal transection was performed by ultrasonic aspirator and Hem-o-Lok clips. The right hepatic artery, right hepatic duct, and the anterior and posterior branches of right portal vein were meticulously dissected, clamped, and transected. The right hepatic vein was transected by vascular stapler. A Y-graft of the recipient's own portal confluence was reconstructed with the donor's separate right anterior and posterior portal veins.

Outcomes:
The donor's operation time was 420 minutes and the warm ischemia time was about 9 minutes. Blood loss was less than 600 ml without transfusion. The donor was discharged at the 10th postoperative day without any complications.

Lessons:
Laparoscopic right hepatectomy for donors with anomalous portal vein branching and subsequent inflow reconstruction for adult living donor liver transplantation is safe and feasible in highly experienced center.
Manganese levels and hepatocellular carcinoma
Authors: Chen Xiu-Bing , Wei Yue-Hui , Chen Xiu-Ke , Zhong Jian , Zou You-Bao , Nie Jia-Yan 
Published: August 2019

Abstract
Several studies have investigated the relationship between Manganese (Mn) levels and hepatocellular carcinoma (HCC), but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between Mn levels and HCC. Nine studies focusing on hair Mn levels, 6 studies on serum Mn levels and 6 studies on tissue Mn levels were identified in a systematic search of PubMed, CNKI, Wanfang and SinoMed databases. Standard mean differences (SMD) with the corresponding 95% confidence intervals (CI) were pooled to compare the Mn levels between HCC and controls. In serum, the Mn levels in HCC were significantly lower than in healthy controls (SMD (95% CI): −0.941 (−1.559, −0.323)). In hair, the Mn levels in HCC were slightly lower than in healthy controls, but not significant (SMD (95% CI): −0.168 (−0.766, 0.430)). In tissue, the Mn levels in tumors were significantly lower than in adjacent normal tissues (SMD (95% CI): −4.867 (−7.143, −2.592)). Subgroup analysis showed consistent results. In conclusion, this meta-analysis suggested an inverse association between Mn levels and HCC.
Acupuncture for rehabilitation after surgery for cerebellopontine angle meningioma
Authors: Han Dexiong , Shen Yejing , Hu Hantong , Zhang Ying , Li Xingling , Fang Lianqiang , Gao Hong 
Published: August 2019

Abstract

Rationale:
In some cases, surgery of cerebellopontine angle meningioma (CPAM) might result in multiple cranial nerve injury, which could bring serious impact on the patients, especially when it affects the function of facial muscles and eyeballs. This report describes a successful application of acupuncture for rehabilitation in a patient after surgery for CPAM.

Patient concerns:
A 27-year-old patient presented with limitation of left eye abduction, accompanied with frontal and facial sensory disturbance on the left after resection of the pontocerebellar angle tumor. The patient also suffered from significant anxiety and depression as concomitant symptoms.

Diagnoses:
Based on medical history, clinical symptoms, and magnetic resonance imaging results, the patient was diagnosed with the fourth, fifth, sixth, and seventh cranial nerve injury after surgery for CPAM.

Interventions:
Acupuncture treatment was applied for this patient. One acupuncture session was given every 2 days in 35 days, and the needles were retained for 30 minutes per session.

Outcomes:
After acupuncture treatment, the limitation of left eye abduction had totally recovered. The superficial sensory disturbance in the frontal and facial region was significantly relived. Besides, the scores of Hamilton Anxiety and Depression Scale showed a significant reduction. However, the superficial sensory of the alar and nasolabial groove on the left side still decreased mildly when compared with the right side.

Conclusion:
Acupuncture might be an option for rehabilitation after surgery for CPAM.
High 2-year mortality and recurrent infection rates after surgical treatment for primary septic arthritis of the hip in adult patients
Authors: Kao Feng-Chen , Hsu Yao-Chun , Liu Pao-Hsin , Tu Yuan-Kun , Jou I-Ming 
Published: August 2019

Abstract
Primary septic arthritis of the hip is rare and potentially devastating in adults. Its optimal surgical treatment and clinical outcomes remain unclear.
In this retrospective cohort study, we investigated mortality and reinfection rates after surgery of patients with septic hip arthritis. We reviewed patients treated for primary septic hip joints from October 2005 to December 2016. A total of 51 adult patients were identified, and 38 among them had destructive hip joints. A poor postoperative outcome was defined as mortality or recurrent infection within 2 years of surgery.
After surgery, 7 (13.7%) patients died within 1 year and 5 (9.8%) patients developed a recurrent hip infection within 2 years. Therefore, poor outcomes occurred in 22% (n = 11) of the study cohort. Among the 38 patients with a destructive hip joint, 7 (18.4%) died within 1 year after surgery and 4 (10.5%) developed a recurrent hip infection within 2 years of surgery. Correlative infections other than infected hip joint and liver cirrhosis were identified as risk factors for poor outcomes.
In conclusion, clinical physicians treating adult primary septic hip joints should be cognizant of the high failure rate of surgical treatment. In addition, the high mortality rate should be considered during the discussion of surgical treatment with these patients and their families.
Three-year major clinical outcomes of phosphorylcholine polymer- vs biolinx polymer-zotarolimus-eluting stents
Authors: Kim Yong Hoon , Her Ae-Young , Rha Seung-Woon , Choi Byoung Geol , Choi Se Yeon , Byun Jae Kyeong , Park Yoonjee , Kang Dong Oh , Jang Won Young , Kim Woohyeun , Choi Woong Gil , Kang Tae Soo , Ahn Jihun , Park Sang-Ho , Park Ji Young , Lee Min-Ho , Choi Cheol Ung , Park Chang Gyu , Seo Hong Seog 
Published: August 2019

Abstract
There are limited long-term outcome data comparing BioLinx polymer (B)-zotarolimus-eluting stents (ZES) with phosphorylcholine polymer (P)-ZES. The aim of this study was to compare the efficacy and safety of B-ZES with P-ZES in patients who underwent percutaneous coronary intervention (PCI) during a 3-year follow-up period.
One thousand two hundred fifty four patients who underwent PCI with P-ZES (Endeavor [ZES-E] or Endeavor sprint [ZES-S], n = 356) or B-ZES (Endeavor resolute [ZES-R] or Resolute Integrity [ZES-I], n = 889) were enrolled. The primary endpoint was major adverse cardiac events (MACE); the composite of total death, non-fatal myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), non-target vessel revascularization (Non-TVR), and the secondary endpoint was stent thrombosis (ST).
After PSM, 2 propensity-matched (PSM) groups (275 pairs, n = 550, C-statistic = 0.730) were generated. During the 3-year follow-up period, the cumulative incidence of MACE (hazard ratio [HR], 1.525; 95% confidence interval [CI], 0.920–2.526; P = .101) and ST (HR, 1.248; 95% CI, 0.335–4.4649; P = .741) were similar between P-ZES and B-ZES after PSM. However, TLR rate was significantly higher in ZES-S than ZES-I (11.3% vs 3.8%, log rank P = .029) and TVR rate was higher in ZES-S than ZES-R (14.1% vs 4.8%, log rank P = .025).
In this single-center, all-comer registry, despite different polymers, P-ZES, and B-ZES showed comparable safety and efficacy during a 3-year follow-up period after PCI.
Understanding Inherited Risk in Unselected Newly Diagnosed Patients With Endometrial Cancer
Authors: Cadoo Karen A. , Mandelker Diana L. , Mukherjee Semanti , Stewart Carolyn , DeLair Deborah , Ravichandran Vignesh , Srinivasan Preethi , Hurley Daire , Kemel Yelena , Arnold Angela G. , Sheehan Margaret , Pradhan Nisha , Joseph Vijai , Chi Dennis S. , Gardner Ginger J. , Jewell Elizabeth L. , Leitao Mario M. , Roche Kara Long , Mueller Jennifer J. , Sonoda Yukio , Zivanovic Oliver , Walsh Michael , Carlo Maria I. , Berger Michael F. , Hyman David M. , Zhang Liying , Robson Mark E. , Offit Kenneth , Aghajanian Carol , Abu-Rustum Nadeem R. , Stadler Zsofia 
Published: August 2019

(Abstracted from JCO Precision Oncology 2019; doi: 10.1200/PO.18.00338)
Endometrial cancer remains the most common gynecologic malignancy. Fortunately, approximately 70% of patients present with an early-stage disease with curative options.
Brain mechanisms impacted by psychological therapies for pain: identifying targets for optimization of treatment effects
Authors: Cunningham Natoshia R. , Kashikar-Zuck Susmita , Coghill Robert C. 
Published: August 2019

Abstract
Psychological therapies, such as cognitive behavioral therapy, are widely used multifaceted approaches that have been shown to improve pain-related functioning. A small but growing number of studies have used brain imaging to support the use of psychological therapies for pain. Although these studies have led to an increased understanding of how therapies may engage neural systems, there are multiple technical and conceptual challenges to consider. Based on the current literature, several components of effective psychological therapies for pain may be supported by changes in neural circuitry, which are most consistently represented by diminished activation and/or reduced hyperconnectivity in brain regions related to pain processing, emotion, and cognitive control. Findings may vary based on methodological approaches used and may also differ depending on targets of treatment. To provide a nuanced understanding of the current literature, specific targets and components of effective treatments for which a neural basis has been investigated are reviewed. These treatment components include catastrophic thinking about pain, increasing self-efficacy, mindfulness, anxiety symptom reduction, and exposure-based approaches. In general, such strategies have the potential to normalize regional hyperactivations and reduce hyperconnectivity in brain regions associated with nociceptive processing, cognition, and emotion, although additional research is needed. By determining if there are indeed distinct brain mechanisms engaged by different components of psychological therapy and evidence for specific changes in neural function after these interventions, future therapies may be more optimally tailored for individuals afflicted with chronic pain.
Introduction to a Special Issue on Innovations and Controversies in Brain Imaging of Pain: Methods and Interpretations
Authors: Davis Karen D. 
Published: August 2019

Abstract
This special issue comprised 14 articles from leaders in the field, that provide opinions and reviews of concepts that are central to the next generation of pain imaging studies. Topics include cutting-edge technologies and approaches that are at the forefront of such studies, as well as developments toward biomarkers of pain and clinical applications that bring us closer to harnessing understanding of pains and its modulation to offer better options to those suffering from pain.
Delayed Graft Function in Simultaneous Liver Kidney Transplantation
Authors: Weeks Sharon R. , Luo Xun , Haugen Christine E. , Ottmann Shane E. , Gurakar Ahmet O. , Naqvi Fizza F. , Alqahtani Saleh A. , Philosophe Benjamin , Cameron Andrew M. , Desai Niraj M. , Segev Dorry L. , Garonzik Wang Jacqueline M. 
Published: August 2019

Background.
Delayed graft function (DGF) is associated with inferior posttransplant outcomes in kidney transplantation. Given these adverse outcomes, we sought to determine the incidence, unique risk factors, and posttransplant outcomes for simultaneous liver kidney (SLK) transplant recipients developing DGF.

Methods.
We studied 6214 adult SLK recipients from March 2002 to February 2017 using the Scientific Registry of Transplant Recipients. We determined associations between risk factors and DGF using Poisson multivariate regression and between DGF and graft failure and mortality using Cox proportional hazard analysis.

Results.
The overall rate of DGF was 21.8%. Risk factors for DGF in the hepatitis C virus (HCV)-negative recipient population included pretransplant dialysis (adjusted incident rate ratio [aIRR] 3.26, P = 0.004), donor body mass index (aIRR 1.25 per 5 kg/m2, P = 0.01), and transplantation with a donation after circulatory death (aIRR 5.38, P = 0.001) or imported donor organ (regional share aIRR 1.69, P = 0.03; national share aIRR 4.82, P < 0.001). DGF was associated with a 2.6-fold increase in kidney graft failure (adjusted hazard ratio [aHR] 2.63, P < 0.001), 1.6-fold increase in liver graft failure (aHR 1.62, P < 0.001), and 1.6-fold increase in mortality (aHR 1.62, P < 0.001).

Conclusions.
In HCV-negative SLK recipients, recipient pretransplant dialysis and components of kidney graft quality comprise significant risk factors for DGF. Regardless of HCV status, DGF is associated with inferior posttransplant outcomes. Understanding these risk factors during clinical decision-making may improve prevention of DGF and may represent an opportunity to improve posttransplant outcomes.
Long-term Kinetics of Intragraft Gene Signatures in Renal Allograft Tolerance Induced by Transient Mixed Chimerism
Authors: Matsunami Masatoshi , Rosales Ivy A. , Adam Benjamin A. , Oura Tetsu , Mengel Michael , Smith Rex-Neal , Lee Hang , Cosimi A. Benedict , Colvin Robert B. , Kawai Tatsuo 
Published: August 2019

Background.
Renal allograft tolerance (TOL) has been successfully induced in nonhuman primates (NHPs) and humans through the induction of transient mixed chimerism. To elucidate the mechanisms of TOL, we compared local immunologic responses in renal allografts with those in T-cell–mediated rejection (TCMR) and chronic antibody–mediated rejection (CAMR) in NHPs.

Methods.
Using the NanoString nCounter platform, we retrospectively studied 52 mRNAs in 256 kidney allograft samples taken from NHP kidney recipients of donor BMT. No immunosuppression was given after 1-month post–donor BMT. Recipients who achieved TOL (n = 13) survived for >1840 ± 1724 days with normal kidney function, while recipients with CAMR (n = 13) survived for 899 ± 550 days with compromised graft function, and recipients with TCMR (n = 15) achieved only short-term survival (132 ± 69 days).

Results.
The most prominent difference between the groups was FOXP3, which was significantly higher in TOL than in CAMR and TCMR, both early (<1 y, P < 0.01) and late (≥1 y, P < 0.05) after transplant. Other mRNAs related to regulatory T cells (Treg), such as IL10, TGFB, and GATA3, were also high in TOL. In contrast, transcripts of inflammatory cytokines were higher in TCMR, while activated endothelium-associated transcripts were higher in CAMR than in TOL. The receiver operating characteristic analyses revealed that intragraft FOXP3 and CAV1 can reliably distinguish TOL from CAMR.

Conclusions.
High FOXP3 and other Treg-related mRNAs together with suppressed inflammatory responses and endothelial activation in renal allografts suggest that intragraft enrichment of Treg is a critical mechanism of renal allograft TOL induced by transient mixed chimerism.
Number of Antibody-verified Eplet in HLA-C Locus as an Independent Factor of T-cell–Mediated Rejection After Liver Transplantation
Authors: Guiral Sandra , Segundo David San , Irure Juan , Casafont Fernando , Fortea Jose Ignacio , Puente Ángela , López-Hoyos Marcos , Crespo Javier , Fabrega Emilio 
Published: August 2019

Background.
HLA mismatching is a risk factor for graft rejection in solid organ transplantation. Its definition is being rethought with the introduction of the eplets in organ allocation. The eplets are highly polymorphic regions of the HLA molecule that help to explain cross-reactivity of HLA antigens. The effect of eplet mismatch is well documented in renal and lung transplantation but there is no clear evidence in liver transplantation.

Methods.
Forty-three consecutive liver-graft donor/recipient pairs performed at our center from 2016 to 2018 were HLA typed. The quantification of antibody-verified eplets (VerEp) mismatch was performed with HLA-matchmaker 2.1 version.

Results.
A total of 9 patients suffered an episode of T-cell–mediated rejection (TCMR). No significant differences were observed in the number of A, B, DRB, DQA, and DQB VerEp. However, the mean of mismatches VerEp in locus C (VerEpC) was significantly increased in patients with acute rejection: 3.89 (1.36) versus 2.32 (1.82), P = 0.021. A total of 22 patients with high load of VerEpC (>2) had an increased risk of TCMR (P = 0.008). The time of TCMR-free after liver transplant was statistically reduced in high-load VerEpC group (log-rank test P = 0.019). Multivariate analysis demonstrated that high load of VerEpC was independently associated with TCMR (P = 0.038).

Conclusions.
Patients with no or 1 eplet mismatch at the C locus are less likely to suffer TCMR after liver transplantation.
De novotranscriptome profiling of mustard aphid (Lipaphis erysimi) and differential expression of transcripts associated with developmental stages, feeding and non-feeding conditions
Authors: Chongtham Rubina , Kulkarni Kirti , Shukla Rohit Nandan , Joshi Gopal , Kumar Amar , Goel Shailendra , Agarwal Manu , Jagannath Arun 
Published: August 2019

AbstractLipaphis erysimiis a Brassicaceae specialist aphid, which causes significant losses in yield and/or reduction of oil content of vegetable and oilseed brassicas and is a major pest in the Indian subcontinent. This study reports thede novotranscriptome ofL. erysimifor the first time. We also present a comparative analysis of nymphs and adult transcriptomes to study the differential expression profiles associated with different developmental stages as well as different feeding conditions. For this, RNA-seq was performed on three different biological samples adults, nymphs (with all nymph stages pooled) and adults starved for 3 hours (referred to as Adult Feeding, AF; Nymphs Feeding, NF, and Adult Starved_3 hr, ANF samples henceforth). A final transcriptome comprising 52,652 transcripts of 1064bp average length and N50 value of 1806 bp was generated. A total of 27,112 transcripts were annotated with insect proteins from SwissProt, of which 4128 transcripts were components of 165 KEGG pathways. A total of 17,296 transcripts were classified based on their Gene Ontology. Potential transcripts for host selection, detoxification, salivary proteins and effectors, molecular chaperones and developmental genes were identified. A total of 23,532 transcripts that remained unannotated were subjected to BLAST against aphid sequences available at AphidBase and a total of 3091 transcripts had hits with sequences of other aphids in the database, out of which 1380 had protein hits. A total of 20441 found to share no homology to any sequence available in the public domain and could therefore represent novel aphid genes or sequences that are unique toL. erysimi. This is an exploratory study with no biological replicates. However, the significant repertoire of feeding- and development-related genes and their differential expression profiles generated in this study adds to the limited data available onL. erysimiand it would facilitate studies on the molecular basis of aphid feeding and development. This could also allow identification of novel target genes for development of RNAi-based aphid control methods.
Nucleic acid amplification by a transparent graphene Visual-PCR chip and a disposable thermocycler
Authors: Zhu Guozhi , Qiao Miao 
Published: August 2019

ABSTRACTPolymerase chain reaction (PCR) is a method widely used to amplify trace amount of nucleic acids. It needs a process of thermocycling (repeated alternation of temperature). Traditional thermocycler relies on bulk size of metal block to achieve thermocycling, which results in high cost and the lack of portability. Here, a PCR chip made of graphene Transparent Conductive Films (TCFs) was employed. The thermocycling of the chip was fulfilled by a temperature programed microcontroller and a cooling fan under a low driving voltage (12V). A 35 cycles PCR was accomplished within 13 minutes using the chip and the thermocycler. The transparency of the graphene PCR chip enables the PCR reaction to be visually monitored by naked eye for a color change. The PCR chip and the thermocycler have a low cost at $2.5 and $6 respectively, and thus are feasible for Point-of-care testing (POCT) of nucleic acids in a disposable manner. The whole platform makes it possible to perform a low-cost testing of nucleic acids for varieties of purposes outside of laboratories or at resource limited locations.