bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-port laparoscopic surgery as a useful diagnostic tool for primary ovarian lymphoma: a case report
Authors: Osanai Kiyono , Misawa Akihiko , Mitsuya Shion , Osaka Makoto , Sato Yasunori , Suzuki Atsushi 
Published: November 2024

Abstract
The preoperative diagnosis of ovarian lymphoma, a rare pathology, is often difficult. Consequently, laparotomy is usually performed under the presumptive diagnosis of ovarian cancer. In cases where the initial curative surgery for ovarian cancer is challenging, diagnostic laparoscopy is performed. Herein, we report a case in which single-port laparoscopic surgery effectively diagnosed primary ovarian lymphoma. A 55-year-old woman presented with abnormal uterine bleeding. PET-CT findings suggested ovarian cancer with multiple metastases. Single-port laparoscopic surgery was performed because curative surgery was deemed difficult. She had an uneventful recovery and was discharged on the fourth postoperative day. After the pathological diagnosis was made, she was referred to the hematology department for treatment. Diagnostic laparoscopy is recommended for advanced ovarian cancer to facilitate early postoperative treatment. This case highlights the utility of single-port laparoscopic surgery in the accurate diagnosis and early treatment of intraperitoneal malignancies.
“My Back Went Out Again!”: You Are Seeing Them at 1:00
Authors: Barr Karen 
Published: November 2024

Abstract
Up to 75% of patients with low back pain (LBP) will have recurrences (flares), so recurrence of LBP is not a reason to suspect serious pathology. A systematic approach to the evaluation of recurrent LBP, management of associated risk factors and comorbidities, and education to teach self-management can help patients function better and reduce associated health care costs. Unnecessary medical investigations can lead to expensive but ineffective and potentially harmful health care and paradoxically increase the risk of long-term, back-related disability. Many of the risk factors for transition to chronic LBP can be reduced with lifestyle modifications and attention to mental health (as depression is seen in 30–50% of patients with persistent pain). Psychosocial distress and fear are significant contributors to LBP and disability. Teaching techniques to self-manage recurrent LBP and facilitating their is an effective way to reduce overutilization of health care and decrease back-related disability and pain.
“Of Course My Back Hurts—I Have Two Bulging Discs”
Authors: Davis Charles , Standaert Christopher J. , Jarvik Jeffrey G. 
Published: November 2024

Abstract
Although spinal imaging can be very helpful in identifying pathology, very few spines actually appear “normal” on MRI, and the majority of “abnormalities” are common, age-related changes. It is critical that medical providers understand the nature and prevalence of imaging findings and can translate and interpret the findings appropriately for their patients. Findings of disc degeneration are a normal manifestation of aging and are commonly seen on spinal imaging in people without LBP. “Degenerative disc disease” is an inaccurate, poorly defined phrase associated with harmful effects on patients and should not be used. Disc bulges and herniations are present in 50% and 33% of the population, respectively, by age 40. Spinal imaging without clear medical/neurological concerns is associated with higher costs and worse outcomes. Reinforcing unproven beliefs around causes of pain can be harmful to patients and lead to perceptions of disability or unrealistic expectations of a structural cure.
“They Told Me I Have a ‘Spondy.’ ”: A 52-Year-Old with Low Back Pain
Authors: Standaert Christopher J. , Standaert Jaxon E. 
Published: November 2024

Abstract
Isthmic spondylolysis with or without spondylolisthesis is seen on radiographs in about 6% of adults and is typically not a source of pain. Spondylolisthesis is defined as the anterior displacement of one vertebral body over the subjacent vertebral body and can be loosely translated to patients as a “spine-slip.” Isthmic spondylolisthesis is associated with fractures of the pars interarticularis that typically occur in childhood without symptoms. Most isthmic spondylolistheses occur at L5/S1 (twice as often in men as in women) and are not associated with or a cause of low back pain (LBP) in adults. Most adults with asymptomatic isthmic spondylolisthesis can be assured that the condition has been there since they were a child, is not causing LBP, and the risk of significant progression is very low. The presence of significant leg pain, however, suggests nerve root involvement associated with a spondylolisthesis and warrants further evaluation.
“I’ve Been Coughing a Lot, Too.”: A 68-Year-Old Smoker with a Cough and Back Pain
Authors: Bailey Robert L. , Sullivan Jessica 
Published: November 2024

Abstract
It is critical to have an understanding of the clinical presentation and initial management of a patient with suspected vertebral metastases. Lung, breast, prostate, renal cell, myeloma, lymphoma, thyroid, and melanoma are the most likely primary tumors to metastasize to the spine. A history of cancer is the strongest predictive factor for metastatic disease in the spine, although night pain, older age, younger age, and constitutional symptoms also are relevant considerations. A patient presenting with potential metastatic disease of the spine and concurrent neurological loss should be referred for emergent evaluation and care. Magnetic resonance imaging is the diagnostic study of choice when spinal metastatic disease is a concern, and all patients require a thorough history and physical examination as well as plain radiographs of the spine. Decisions about surgery are made in the context of the clinical presentation, imaging findings, pathology, patient preferences, and a comprehensive approach to care.
“I Just Keep Getting Worse.”: Long-Standing Depression and Progressive Low Back Pain
Authors: Tuck Laura M. , Brier Moriah J. , Ho Erica , Anderson Derek R. , Williams Rhonda M. , Standaert Christopher J. , Turner Aaron P. 
Published: November 2024

Abstract
The comorbid presentation of chronic low back pain (LBP) and depression is common. Estimates suggest over half of patients with chronic pain also have major depression. Depression, in turn, can contribute to the maintenance of chronic pain through social withdrawal, negative thinking, and reduced activity. It is important therefore to assess biological, psychological, and social factors contributing to the pain experience and provide education about the interrelationship between pain and depression, neither of which can be treated in isolation. Individuals with comorbid mental health concerns (especially long-standing) and chronic pain are among the most complex patients to treat. Effective treatment entails a multifaceted approach focused on improving function, insight into the interrelationship of pain and mental health issues, self-efficacy in sustained lifestyle changes, and establishing clear functional goals. This requires buy-in and engagement from the patient and should be viewed as a collaboration between patients and providers.
“It Hurts, and I’m Not Walking Right.”: A Veteran with Back Pain and a Below Knee Prosthesis
Authors: Keszler Mary S. , Morgenroth David C. , Greis Ari , Williams Rhonda M. , Standaert Christopher J. 
Published: November 2024

Abstract
Low back pain (LBP) is more common in persons with lower limb loss (PWLL) than in the general population, and unique considerations arise in the evaluation and management of these individuals. Clinicians should consider intrinsic, prosthesis-related, and biopsychosocial factors. Military veterans with traumatic limb loss have relatively high rates of post-traumatic stress disorder, depression, anxiety, and kinesiophobia (fear of movement). While PWLL are also prone to the same spine pathologies that may affect anyone, limb loss adds specific considerations for examination and may limit the ability to perform a neurological examination. All PWLL with new, progressive, or limiting LBP need a thorough evaluation including an assessment of prosthetic fit and gait (when applicable), neurological status, and psychological status. Spinal imaging can be particularly helpful when clinical evaluation is clouded by some of the complexities associated with limb loss. Care should be taken to approaching PWLL comprehensively and promptly.
“I Have Tried Everything for My Back Pain!”: What to Do When There Is Nothing Left to Do
Authors: Standaert Christopher J. 
Published: November 2024

Abstract
Many with low back pain (LBP) are frustrated with their pain and their care, often noting that they “have tried everything.” Care for LBP centers around treating LBP as a nonspecific, self-limiting problem, or chasing “pain generators” identified on imaging that can be “fixed” by some type of intervention. Both of these are wrong. There is no medication, interventional procedure, or surgery shown to reliably provide long-term relief of LBP. Those with LBP often develop a misunderstanding of their medical evaluation, the role of physical therapy, and the potential for medical/ surgical approaches to “fix” their problem. a Effective treatment requires understanding the complexities of their life, education, and empowerment. Sleep, exercise, diet, social engagement, and goals/ passions are fundamental human needs and care is structured around rebuilding these. The solution lies in helping people to improve their life rather than eliminating their pain.
Material mixing in pulsar wind nebulae of massive runaway stars
Authors: Meyer D M -A , Torres D F 
Published: November 2024

ABSTRACT
In this study we quantitatively examine the manner pulsar wind, supernova ejecta, and defunct stellar wind materials distribute and melt together into plerions. We performed 2.5D magnetohydrodynamical simulations of the entire evolution of their stellar surroundings and different scenarios are explored, whether the star dies as a red supergiant and Wolf–Rayet supernova progenitors, and whether it moved with velocity 20 or $40\, \rm km\, \rm s^{-1}$ through the interstellar medium. Within the post-explosion, early $10\, \rm kyr$, the H-burning-products rich red supergiant wind only mixes by $\le 20~{{\rm per\ cent}}$, due to its dense circumstellar medium filling the progenitor’s bow shock trail, still unaffected by the supernova blast wave. Wolf–Rayet materials, enhanced in C, N, O elements, distribute circularly for the $35\, \rm M_\odot$ star moving at $20\, \rm km\, \rm s^{-1}$ and oblongly at higher velocities, mixing efficiently up to 80 per cent. Supernova ejecta, filled with Mg, Si, Ca, Ti, and Fe, remain spherical for longer times at $20\, \rm km\, \rm s^{-1}$ but form complex patterns at higher progenitor speeds due to earlier interaction with the bow shock, in which they mix more efficiently. The pulsar wind mixing is more efficient for Wolf–Rayet (25 per cent) than red supergiant progenitors (20 per cent). This work reveals that the past evolution of massive stars and their circumstellar environments critically shapes the internal distribution of chemical elements on plerionic supernova remnants, and, therefore, governs the origin of the various emission mechanisms at work therein. This is essential for interpreting multifrequency observations of atomic and molecular spectral lines, such as in optical, infrared, and soft X-rays.
Identifying dark matter signals by the radio continuum spectral data of the cool-core cluster RX J1720.1+2638
Authors: Chan Man Ho , Lee Chak Man 
Published: November 2024

ABSTRACT
Investigating the signals of dark matter annihilation is one of the most popular ways to understand the nature of dark matter. In particular, many recent studies are focussing on using radio data to examine the possible signals of dark matter revealed in galaxies and galaxy clusters. In this article, we investigate on the spectral data of the central radio halo of the cool-core cluster RX J1720.1+2638. We show that the radio spectral data can be best accounted by the synchrotron emission due to dark matter annihilation via $\tau$ lepton channel (with dark matter mass $m=15$ GeV) or b quark channel (with dark matter mass $m=110$ GeV), although using the very coarse spectral data with notable errors. Despite the fact that cosmic-ray emission can also provide a good explanation for the observed radio spectrum, our results suggest a possible positive evidence for dark matter annihilation revealed in the form of radio emission in RX J1720.1+2638 cluster.
A possible misaligned orbit for the young planet AU Mic c
Authors: Yu H , Garai Z , Cretignier M , Szabó Gy M , Aigrain S , Gandolfi D , Bryant E M , Correia A C M , Klein B , Brandeker A , Owen J E , Günther M N , Winn J N , Heitzmann A , Cegla H M , Wilson T G , Gill S , Kriskovics L , Barragán O , Boldog A , Nielsen L D , Billot N , Lafarga M , Meech A , Alibert Y , Alonso R , Bárczy T , Barrado D , Barros S C C , Baumjohann W , Bayliss D , Benz W , Bergomi M , Borsato L , Broeg C , Cameron A Collier , Csizmadia Sz , Cubillos P E , Davies M B , Deleuil M , Deline A , Demangeon O D S , Demory B -O , Derekas A , Doyle L , Edwards B , Egger J A , Ehrenreich D , Erikson A , Fortier A , Fossati L , Fridlund M , Gazeas K , Gillon M , Güdel M , Helling Ch , Isaak K G , Kiss L L , Korth J , Lam K W F , Laskar J , Lecavelier des Etangs A , Lendl M , Magrin D , Maxted P F L , McCormac J , Merín B , Mordasini C , Nascimbeni V , O’Brien S M , Olofsson G , Ottensamer R , Pagano I , Pallé E , Peter G , Piazza D , Piotto G , Pollacco D , Queloz D , Ragazzoni R , Rando N , Rauer H , Ribas I , Santos N C , Scandariato G , Ségransan D , Simon A E , Smith A M S , Sousa S G , Southworth R , Stalport M , Steinberger M , Sulis S , Udry S , Ulmer B , Ulmer-Moll S , Van Grootel V , Venturini J , Villaver E , Walton N A , Wheatley P J 
Published: November 2024

ABSTRACT
The AU Microscopii planetary system is only 24 Myr old, and its geometry may provide clues about the early dynamical history of planetary systems. Here, we present the first measurement of the Rossiter–McLaughlin effect for the warm sub-Neptune AU Mic c, using two transits observed simultaneously with the European Southern Observatory's (ESO's) Very Large Telescope (VLT)/Echelle SPectrograph for Rocky Exoplanets and Stable Spectroscopic Observations (ESPRESSO), CHaracterising ExOPlanet Satellite (CHEOPS), and Next-Generation Transit Survey (NGTS). After correcting for flares and for the magnetic activity of the host star, and accounting for transit-timing variations, we find the sky-projected spin–orbit angle of planet c to be in the range $\lambda _{\mathrm{c}}=67.8_{-49.0}^{+31.7}$ degrees (1$\sigma$). We examine the possibility that planet c is misaligned with respect to the orbit of the inner planet b ($\lambda _{\mathrm{b}}=-2.96_{-10.30}^{+10.44}$), and the equatorial plane of the host star, and discuss scenarios that could explain both this and the planet’s high density, including secular interactions with other bodies in the system or a giant impact. We note that a significantly misaligned orbit for planet c is in some degree of tension with the dynamical stability of the system, and with the fact that we see both planets in transit, though these arguments alone do not preclude such an orbit. Further observations would be highly desirable to constrain the spin–orbit angle of planet c more precisely.
Appeal and Sensory Characteristics of Oral Nicotine Products in Young Adults Who Vape E-Cigarettes
Authors: Peraza Natalia , Han Dae Hee , Whaley Reid C , Vogel Erin A , Monterosso John R , Gonzalez Anaya Maria J , Patel Devaki J , Jafarzadeh Nikki S , Hong Kurt , Mason Tyler B , Tackett Alayna P , Leventhal Adam M 
Published: November 2024

Abstract

Introduction
This study applied a novel tobacco regulatory science paradigm to characterize inter-product variation in the appeal and sensory features of emerging commercial and therapeutic oral nicotine products (ONPs) among young adults who vape e-cigarettes.

Aims and Methods
Twenty-three young adults without ONP experience who use e-cigarettes completed a single-blind, single-visit remote lab study. Participants rated appeal and sensory characteristics during 5-minute standardized self-administrations of eight ONPs (four fruits and four mints) from various brands (Lucy, Rouge, Solace, Nicorette, On!, and Velo). Participants were randomized between-subjects to ONP type (pouches or gum).

Results
Gum ONPs were rated sweeter (B = 19.5, 95% Confidence Interval (CI) = 4.3, 34.7), stronger in flavor (B = 25.6, 95% CI = 12.2, 39.0), and lower in tingling sensation (B = −14.0, 95% CI = −27.8, −0.2) than pouches. Fruit-flavored ONPs were sweeter (B = 12.9, 95% CI = 6.1, 19.7) and caused less burning (B = −12.0, 95% CI = −19.5, −4.5) than mint. Product type × flavor interactions found that gum versus pouch enhanced sweetness and flavor strength more for fruit than mint, while pouch versus gum increased burning and harshness more for mint. Nicorette White Ice was most appealing, while Rogue Fruit and Nicorette Mint were less so. Appeal correlated with most types of sensory experiences (rs = −0.33–0.54), except for tingling and burning.

Conclusions
Nicotine gums may offer a more pleasant sensory experience than pouches for young adults who use e-cigarettes, with variation across brand/flavor variants.

Implications
Results indicate that gum ONPs and fruit flavors may offer greater appeal and a more pleasant sensory experience than pouch ONPs and mint flavors for young adults who use e-cigarettes and are ONP-naïve, with heterogeneity in user experience across some brand/flavor variants. This study also introduces a method for assessing the appeal and sensory features of ONPs, which can inform regulatory efforts and strategies to reduce nicotine dependence among young adults who use e-cigarettes.
Protein phosphatase PP2C19 controls hypocotyl phototropism through the phosphorylation modification of NONPHOTOTROPIC HYPOCOTYL3 in Arabidopsis
Authors: Sakai Tatsuya , Haga Ken , Kimura Taro , Kawaura Keita 
Published: November 2024

Abstract
Plants exhibit shoot growth in the direction of the light source to facilitate photosynthesis, known as positive phototropism. In Arabidopsis hypocotyl phototropism, it is thought that a gradient of the signal intensity of the blue light (BL) photoreceptor phototropin1 (phot1) between the light-irradiated and shaded sides leads to the differential growth of hypocotyls. The intensity of phot1 signal is regulated not only by the protein kinase activity of phot1 but also by the phosphorylation status of the NONPHOTOTROPIC HYPOCOTYL3 (NPH3) protein, which has a dark form and a BL form of the phosphorylation modification. Previous studies have shown that phot1 drives the forward reaction from the dark form to the BL form of NPH3. However, the molecular mechanism underlying the reverse reaction remains unknown. Here, we show that protein phosphatase PP2C19 controls the reverse reaction that converts the BL form of NPH3 to the dark form of NPH3. The PP2C19 protein possesses the protein phosphatase type 2C (PP2C) domain, two cyclic nucleoside monophosphate (cNMP)-binding domains, and the protein kinase domain. Similar to phot1 and NPH3, PP2C19 localizes to the plasma membrane, and its PP2C domain is necessary and sufficient for PP2C19 function in hypocotyl phototropism. The pp2c19 mutants show abnormalities in second positive hypocotyl phototropism with a delay in the reverse reaction of NPH3 phosphorylation modification. The present study suggests that continuous BL irradiation induces an equilibrium state of the reversible reaction of NPH3 phosphorylation, which acts as a phot1 signaling gradient with phot1 kinase activity to induce the second positive phototropism.
Mitochondrial DNA copy number and risk of cardiovascular disease and all-cause mortality: a systematic review and meta-analysis of observational studies
Authors: Fu Xueru , Zhao Yang , Ke Yamin , Gao Yajuan , Wang Mengmeng , Chen Yaobing , Huo Weifeng , Wang Longkang , Zhang Wenkai , Wu Yuying , Li Xi , Zhang Dongdong , Hu Fulan , Hu Dongsheng , Zhang Ming 
Published: November 2024

Abstract
Increasing studies have explored the correlation of mitochondrial DNA copy number (mtDNA-CN) abnormalities with cardiovascular disease (CVD) and all-cause mortality; however, their findings are contradictory. This systematic review and meta-analysis sought to quantitatively summarize current studies to elucidate the impact of mtDNA-CN on CVD outcomes and all-cause mortality. Relevant studies were searched for in PubMed, Embase and Web of Science databases, up to 23 October 2023. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated with the random-effects model. In total, 22 articles were included in the systematic review, 13 of which were included in the meta-analysis of CVD outcomes and 8 in all-cause mortality. Compared to the highest mtDNA-CN level, the summary RR (95% CI) for the lowest mtDNA-CN level was 2.09 (95% CI 1.59–2.75) for CVD, 1.70 (95% CI 1.29–2.24) for coronary heart disease (CHD), 1.43 (95% CI 1.15–1.79) for heart failure (HF), 1.88 (95% CI 1.08–3.28) for stroke and 1.33 (95% CI 1.21–1.47) for all-cause mortality. Lower mtDNA-CN may increase the risk of CVD, including CHD, HF and stroke, as well as all-cause mortality. MtDNA-CN is a potential predictor of CVD and all-cause mortality.
Exploring research quality and journal representation: a comparative study of African Journals Online, Scopus, and Web of Science
Authors: Alonso-Álvarez Patricia 
Published: November 2024

Abstract
Based on its perceived objectivity, Scopus and Web of Science (WoS) have been largely considered as sources of journal authority. However, its status has recently been contested due to its linguistic, geographical, and disciplinary biases. This paper studies journal quality and journal representation, focusing on the African publishing environment. It compares three academic data sources: two international indexes—Scopus and WoS—, and a regional journal indexing platform—African Journals Online (AJOL). First, it revises and compares the quality criteria of the three sources to explore the similarities and differences among them. Then, the paper develops a methodology to compare journal coverage of the three data sources in terms of countries, research areas, and language. The results show the importance of implementing a situated notion of research quality and the existing biases of mainstream and alternative academic sources toward specific countries, research areas, and languages. The findings also contribute to the ongoing conversation about diversity and inclusion in science and can be used to assess the limitations of our current bibliometric analysis.