bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum soluble receptor for advanced glycation end‐products during acute bronchiolitis in infant: Prospective study in 93 cases
Authors: Egron Carole , Roszyk Laurence , Rochette Emmanuelle , Jabaudon Matthieu , Sapin Vincent , Mulliez Aurélien , Labbé André , Coste Karen 
Published: August 2018

ABSTRACTIntroductionAcute bronchiolitis is a major cause of acute respiratory distress in infants. The soluble receptor for advanced glycation end‐products (sRAGE) is a biomarker of pulmonary damage processes, with a diagnostic and a prognostic value in acute respiratory distress syndrome (ARDS). The RAGE pathway is also implicated in the pathogenesis of other respiratory diseases like asthma, but the value of sRAGE levels in acute bronchiolitis remains under‐investigated.Material and methodsA prospective, observational, and analytical study was conducted at Clermont‐Ferrand University Hospital. The main objective was to evaluate the correlation between serum sRAGE and clinical severity of bronchiolitis in hospitalized infants aged <1 year. We analyzed correlations between serum sRAGE and Wainwright score, short‐term morbidity attributable to bronchiolitis, causal viruses and risk for recurrent wheezing at 1 year.ResultsThe study included 93 infants. sRAGE levels were significantly lower in acute bronchiolitis patients (mean 1101 pg/mL) than in controls (2203 pg/mL, P < 0.001) but did not correlate with clinical severity. No correlation was found between serum sRAGE and severity score, respiratory viruses, and recurrent wheezing at 1 year. Serum sRAGE levels were negatively correlated with age (r = −0.45, P < 0.001).ConclusionSerum sRAGE levels are decreased in acute bronchiolitis but not correlated with disease severity. sRAGE levels should be age‐adjusted in infants. Serum sRAGE levels measured in the setting of acute bronchiolitis were not predictive of recurrent wheezing.
Bisphenol A vascular toxicity: Protective effect of Vitis vinifera (grape) seed extract and resveratrol
Authors: Rameshrad Maryam , Imenshahidi Mohsen , Razavi Bibi Marjan , Iranshahi Mehrdad , Hosseinzadeh Hossein 
Published: August 2018

The underlying mechanism of Bisphenol A (BPA)‐induced vascular toxicity and the protective role of grape seed extract (GSE) and resveratrol were investigated in vitro and in vivo. Human umbilical vein endothelial cells (HUVECs) were exposed to different concentrations of GSE and resveratrol. Then, BPA was added to the cells and cell viability and effects on the protein level of cell adhesion molecules were measured through MTT and western blotting. Animals were randomly divided into control, GSE (3 and 12 mg·kg−1·day−1 ip), resveratrol (100 mg·kg−1·day−1 ip), BPA (35 mg·kg−1·day−1, gavage), BPA plus GSE (3, 6, and 12 mg·kg−1·day−1 ip), BPA plus resveratrol (25, 50, and 100 mg·kg−1·day−1 ip), and BPA plus vitamin E (200 IU/kg per every other day ip). After 2 months, contractile and relaxant responses were evaluated on the isolated aorta. BPA increased the level of aorta malondialdehyde (p < 0.001) and decreased vascular responses to KCl (p < 0.01), phenylephrine (p < 0.001), and acetylcholine (p < 0.01). In HUVECs, BPA (IC50: 220 μM) increased protein level of vascular cell adhesion molecule (p < 0.05) and cleaved capase3 (p < 0.001). GSE, resveratrol, and vitamin E cotreatment restored toxic effects of BPA in some levels. BPA vascular toxicity was attributed to lipid peroxidation and endothelial dysfunction. The protective role of GSE and resveratrol against BPA‐endothelial dysfunction could be attributed to their potent antioxidant properties.
Does local infiltration anesthesia on laparoscopic surgical wounds reduce postoperative pain? Randomized control study
Authors: Sugihara Mika , Miyake Takahito , Miyagi Yasunari , Oda Takashi , Hazama Yukiko , Sano Rikiya , Nakamura Takafumi , Shiota Mitsuru , Shimoya Koichiro 
Published: August 2018

AbstractPurposeRecently, endoscopic surgeries are widely performed in the gynecological field. Several studies on the use of local anesthesia for pain control after laparoscopic surgery have been conducted; however, its effects remain controversial. Herein, a randomized control study on gynecological laparoscopic surgeries was conducted to analyze the effectiveness of local anesthesia on postoperative pain.MethodsPatients who underwent laparoscopic surgeries due to gynecologic benign diseases or endometrial cancer in the early stage were enrolled, and randomly divided into intervention (injected with levobupivacaine), and control (injected with saline) groups. The primary outcome was the dosage of analgesic consumption within 12 hours postoperatively.ResultsA total of 147 patients were enrolled in the intervention group and 147 in the control group. The outcome of local anesthesia was not significantly different between the two groups during the whole analysis. We analyzed the effects of local anesthesia in the laparoscopic surgery subgroup. The dosage of analgesic consumption within 12 h after a laparoscopic hysterectomy (TLH) or TLH with pelvic lymph node dissection (TLH+PLD) in the intervention group was significantly smaller than that in the control group.ConclusionLocal infiltration anesthesia can effectively reduce postoperative pain in patients who underwent TLH or TLH +PLD.
A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4‐Triazole Derivatives
Authors: Gultekin Ergun , Kolcuoglu Yakup , Akdemir Atilla , Sirin Yakup , Bektas Hakan , Bekircan Olcay 
Published: August 2018

AbstractIn this study, 1‐(4‐substitued benzyl)‐3,5‐diphenyl‐1H‐1,2,4‐triazoles (2 a‐e) and ethyl(3,5‐diphenyl‐1H‐1,2,4‐triazole‐1‐yl)acetate (3) were synthesized starting from 3,5‐diphenyl‐1H‐1,2,4‐triazole (1). The ethyl acetate derivative (3) was converted to 2‐(3,5‐diphenyl‐1H‐1,2,4‐triazole‐1‐yl)acetohydrazide (4) in ethanolic medium with hydrazine hydrate. The reaction of the acetohydrazide (4) with suitable isothiocyanates generate 2‐[(3, 5‐diphenyl‐1H‐1,2,4‐triazole‐1‐yl)acetyl]‐4‐methyl/phenyhlthiosemicarbazide (5 a,b). The cyclization of the thiosemicarbazide (5 a,b) in the presence of NaOH (2 M) resulted in the formation of 5‐[(3, 5‐diphenyl‐1H‐1,2,4‐triazole‐1‐yl)methyl]‐4‐methyl/phenyl‐2,4‐dihidro‐3H‐1,2,4‐triazole‐3‐thiol (6 a,b). Finally, the synthesized 1,2,4‐triazole‐3‐thiols (6 a,b) were converted to their S‐substituebenzyl derivatives (7 a‐j). All of the synthesized compounds (1‐7) were also examined for antioxidant capacities, and antiurease and anti‐acetylcholinesterase (anti‐AChE) activities. It has been found that antioxidant capacity and anti‐urease activity of the compound 7 f is very good in biochemically active compounds.
A Literal Elytral Rainbow: Tunable Structural Colors Using Single Diamond Biophotonic Crystals in Pachyrrhynchus congestus Weevils
Authors: Wilts Bodo D. , Saranathan Vinodkumar 
Published: August 2018

AbstractThe brilliant colors of many insects arise from the interference of incident light with complex nanostructured biomaterials that are present in their cuticle. Here, the rainbow‐colored spots on the elytra of a snout weevil, Pachyrrhynchus congestus pavonius (Coleoptera: Curculionidae), are investigated using synchrotron small‐angle X‐ray scattering, scanning electron microscopy, microspectrophotometry, and photonic bandgap modeling. It is shown that the iridescent scales present in the rainbow‐hued spots are due to a 3D photonic crystal network of chitin in air with a single diamond (Fd‐3m) symmetry. In many insects, different orientations of photonic crystal domains are used to create various hues. In this weevil, however, both the chitin volume fractions as well as the lattice parameters of the biologically self‐assembled single diamond nanostructure are varied to achieve the remarkable tuning of the structural colors across the visible light spectrum on a scale‐by‐scale basis. Uncovering the precise mechanism of color tuning employed by this weevil has important implications for further structural and developmental research on biophotonic nanostructures and may provide fresh impetus for bioinspired and biomimetic multifunctional applications, as synthesis of photonic crystals at visible length scales is currently challenging.
Preparation of standard materials of aerosol particles for X‐ray fluorescence analysis using a small chamber sampling unit
Authors: Nakano Kazuhiko , Oshiro Yoshito , Azechi Sotaro , Somada Yuka , Handa Daishi , Miyagi Yoichi , Tanahara Akira , Arakaki Takemitsu , Itoh Akihide 
Published: August 2018

We investigated the simple and rapid preparation of standard materials of major and trace elements in aerosol particles for X‐ray fluorescence (XRF) analysis to study long‐range transport of air pollutants in East Asia. Standard materials for calibration curve were prepared using a small‐chamber sampling technique consisted of a 3‐L cylindrical acrylic chamber, aerosol filter holder, flow meter, and vacuum pump. Prepared aerosol standard materials had an excellent homogeneity in 0.5 mm × 0.5 mm analytical area. XRF analysis was performed by a bench top energy‐dispersive X‐ray fluorescent spectrometer. For only arsenic analysis, synchrotron radiation XRF was applied because As‐Kα line (10.53 keV) was overlapped by Pb‐Lα line (10.55 keV) in a typical XRF measurement. The calibration curves of 15 elements (K, Ca, Ti, V, Mn, Fe, Ni, Cu, Zn, As, Se, Rb, Sr, Ba, and Pb) showed a good linearity. The prepared standard materials were applied to determine metal elements in total suspended particle (TSP) aerosols, which were collected at Kume Island in Okinawa, Japan, from June 2008 to June 2010, and analytical results in XRF were compared with those of inductively coupled plasma atomic mass spectrometry (ICP‐MS) or atomic absorption spectrometry (AAS). Analytical results of TSP aerosol between XRF and ICP‐MS or AAS had a strong correlation higher than 0.800 for all elements.
Moduli stars
Authors: Krippendorf Sven , Muia Francesco , Quevedo Fernando 
Published: August 2018

AbstractWe explore the possibility that (Bose-Einstein) condensation of scalar fields from string compactifications can lead to long-lived compact objects. Depending on the type of scalar fields we find different realisations of star-like and solitonic objects. We illustrate in the framework of type IIB string compactifications that closed string moduli can lead to heavy microscopic stars with masses of order$$ {\mathcal{V}}^{\alpha }{M}_{\mathrm{Planck}} $$VαMPlanck,α= 1,3/2,5/3 where$$ \mathcal{V} $$Vis the volume of the extra dimensions. Macroscopic compact objects from ultra-light string axions are realised with masses of order$$ {e}^{\mathcal{V}2/3} $$eV2/3MPlanck.Q-ball configurations can be obtained from open string moduli whereas the closed string sector gives rise to a new class of solutions, named PQ-balls, that arise in the two-field axion-modulus system. The stability, the potential for the formation, and the observability of moduli stars through gravitational waves are discussed. In particular we point out that during the early matter phase given by moduli domination, density perturbations grow by a factor$$ {\mathcal{V}}^{\beta } $$Vβwithβ >2 and non-linear effects cannot be neglected.
All Along the Watchtower: a Case of Long QT Syndrome Misdiagnosis Secondary to Genetic Testing Misinterpretation
Authors: Helm Benjamin M. , Ayers Mark D. , Kean Adam C. 
Published: August 2018

AbstractClinical genetics services continue to expand into diverse medical specialties. An ever‐increasing number of non‐genetics providers are independently ordering genetic tests, interpreting results, and at times, making diagnoses leading to patient care recommendations. Non‐genetics healthcare providers can help increase patient access to these services, but a potential pitfall occurs when these providers either do not have adequate expertise with genetic variant interpretation or do not have access to multi‐disciplinary teams including genetic counselors or clinical geneticists for advanced review. In the cardiology setting, variant misinterpretation can lead to misattribution of disease risk, unnecessary treatments or management, and potentially adverse psychosocial and financial effects. To address this, case reports and series are needed to highlight variant misinterpretation and misdiagnoses, including discussion of possible solutions and best practices for avoidance. This report details a child previously diagnosed with long QT syndrome type 4 by chromosomal microarray who was then subsequently managed for this disease by cardiac providers with insufficient expertise to critically review and question the genetic testing results. The patient was eventually referred to a pediatric electrophysiology team as part of a larger multidisciplinary cardiovascular genetics program, composed of specialist genetic counselors, cardiologists, and clinical geneticists. Advanced review and clinical evaluation raised concern about the initial genetic testing result and diagnosis. Complementary testing with a different modality to confirm or disconfirm the chromosome microarray result was performed, providing evidence that the original result reflected analytic error in the laboratory as well as interpretive error by the clinical geneticist and that the patient was misdiagnosed, and treated over the course of years, for long QT syndrome. This case shows the value of multidisciplinary teams caring for patients with inherited cardiovascular diseases.
Safety and efficacy of lithium in children and adolescents: A systematic review in bipolar illness
Authors: Amerio A. , Ossola P. , Scagnelli F. , Odone A. , Allinovi M. , Cavalli A. , Iacopelli J. , Tonna M. , Marchesi C. , Ghaemi S.N. 
Published: August 2018

AbstractIntroduction:Many clinicians are reluctant to use traditional mood-stabilizing agents, especially lithium, in children and adolescents. This review examined the evidence for lithium’s safety and efficacy in this population.Methods:A systematic review was conducted on the use of lithium in children and adolescents with bipolar disorder (BD). Relevant papers published through June 30th 2018 were identified searching the electronic databases MEDLINE, Embase, PsycINFO and the Cochrane Library.Results:30 articles met inclusion criteria, including 12 randomized controlled trials (RCTs). Findings from RCTs demonstrate efficacy for acute mania in up to 50% of patients, and evidence of long-term maintenance efficacy. Lithium was generally safe, at least in the short term, with most common side effects being gastrointestinal, polyuria, or headache. Only a minority of patients experienced hypothyroidism. No cases of acute kidney injury or chronic kidney disease were reported.Conclusions:Though the available literature is mostly short-term, there is evidence that lithium monotherapy is reasonably safe and effective in children and adolescents, specifically for acute mania and for prevention of mood episodes.
Long-term outcomes of (Gore) fistula plug versus ligation of intersphincteric fistula tract for anal fistula
Authors: Alhaddad Abdullah , Mouzannar Ali , Ashraf Aqeel , Marafi Bader , Albader Ibtisam , Alsaid Ali , Alabbad Jasim , Khoursheed Mousa 
Published: August 2018

Abstract
Background The surgical treatment of anal fistula is complex due to the possibility of fecal incontinence. Fistulotomy and cutting Setons have the same incidence of fecal incontinence depending on the complexity of the fistula. Sphincter-preserving procedures such as anal fistula plug and ligation of intersphincteric fistula tract procedure may result in more recurrence requiring repeated operations. The aim of this study was to evaluate and compare the outcomes of treating fistula in Ano utilizing two methods: Fistula plug (Gore Bio-A) and ligation of intersphincteric tract (LIFT).
Methods Fifty four patients (33 males; 21 female, median ages 42 [range 32–47] years) with high anal inter-transphenteric fistula were treated with LIFT and fistula plug procedures from September 2011 until August 2016 by a single surgeon and were retrospectively evaluated. All were followed for a median of 23.9 (range 4–54) months with clinical examination. Twenty one patients underwent fistula plug and 33 patients underwent LIFT procedure (4 patients of the LIFT group underwent LIFT and rectal mucosa advancement flap). The healing rate and complications were evaluated clinically and through telephone calls.
Results The mean operative time for the Plug was 25 ± 17 min and for the LIFT was 40 ± 20 min (p = 0.017) and the mean hospital stay was 2.4 ± 1.1 and 1.9 ± 0.3 (p = 0.01) respectively. The early complications of the plug and LIFT procedures included; anal pain (33.3%, 66.6%, p = 0.13), perianal discharge (77.8%, 91%, p = 0.62), anal pruritus (38.9%, 50.0%, p = 0.71) and bleeding per rectum (16.7%, 33.3%, p = 0.39) respectively. The overall mean follow-up was 20.9 ± 16.8 months, p = 0.68. There was no statistically significant difference between the two groups (21.9 ± 7.5 months, 19.9 ± 16.1 months, p = 0.682). The healing rate was 76.2% (16/21 patients) in the fistula plug group and 81.1% (27/33 patients) in the LIFT group (p = 0.73). Patients who had LIFT procedure and a mucosal advancement flap had 100% healing rate (4 out of 4 patients). No incontinence of stool or feces and no fistula plug expulsion were seen in our patients. The healing time ranged from 1 to 6 months after surgery. There was no post-operative perianal abscess, cellulitis or pain.
Conclusions LIFT and anal plug are safe procedures for patients with primary and recurrent anal fistula. Both techniques showed excellent results in terms of healing and complication rate. None of our patients had incontinence after 5 years follow-up. The best success rate in our patients was seen after LIFT procedure with mucosal advancement flap. Larger and controlled randomized trials are needed for better assessment of treatment options.
Legal reflections on the evolving role of general practitioners in China’s primary care: an assessment of regulatory strategies
Authors: Liu Ziyu , Buijsen Martin 
Published: August 2018

AbstractAimTo assess the regulation of the Chinese healthcare system in assisting a nationwide implementation of general practitioner (GP) services.BackgroundAlong with the perennial problems of unaffordable and inequitable healthcare, a rapidly ageing population and the increasing burden of non-communicable diseases pose challenges to the Chinese healthcare system. Recognising these challenges and to satisfy people’s demands for more and better healthcare, China has initiated a plan, named ‘Healthy China 2030’, based on the findings from a two-year joint study by the World Health Organization (WHO) and the World Bank Group (WBG) in collaboration with Chinese agencies. The Chinese healthcare plan, officially approved in 2016, is an attempt to use the people-centred, integrated care (PCIC) model recommended by the WHO and WBG to shape the Chinese healthcare system. In accordance with PCIC, China began the implementation of gatekeeping primary care by introducing GP services to local communities.MethodsA comparative analysis was employed to point out the importance of introducing GP services. A systematic assessment was carried out to evaluate the regulatory sector of the Chinese healthcare system, including a critical review of related legal norms and a theoretical exploration of external impediments (eg, cultural attitudes, government capacity and interest groups).FindingsResults demonstrate that the current regulatory sector of the Chinese healthcare system needs to be improved in order to assist the nationwide implementation of GP services and to strengthen its gatekeeping role. Major deficiencies include the problematic relationship between legal norms and health policies, the lack of effective and consistent new legislation, the low rate of social acceptance, and lack of support from agencies. To address those challenges, this paper recommends that preliminary efforts be devoted, in part, to two changes in the legal structure: enacting a specific law, and creating an independent regulatory oversight body.
Gustav Jenner and the Music of Brahms: The Case of the Orchestral Serenades
Authors: Sholes Jacquelyn 
Published: August 2018

Gustav Jenner (1865–1920) was Brahms’s only long-term composition student. Jenner, an outspoken proponent of the conservative musical values he shared with Brahms, left numerous songs and pieces for chorus, piano, chamber ensembles and orchestra. Despite his obvious stylistic affinities to Brahms, it is clear from Jenner’s prose writings that he placed high value on artistic independence. Although scholars have noted the circumstances surrounding Jenner’s interactions with Brahms between 1888 and 1895 and Brahms’s general aesthetic influence on the young man, Jenner’s music – and particularly its relationship to that of Brahms – has received scant attention. Deeper comparison of the two composers’ works yields insights into not only how Brahms influenced less prominent composers in his circle and in the generation that followed him, but also the extent and nature of Brahms’s direct influence as a teacher.This article compares Jenner’s only complete orchestral piece, his Serenade in A major (1911–12), with its most obvious precedents, Brahms’s orchestral serenades. Although correlations in general style are numerous, discrepancies arise naturally. Jenner furthermore avoids Brahms’s most distinctive compositional choices and takes care not to rely too heavily on any one Brahmsian model for his own Serenade, suggesting his desire to distinguish himself and a wariness of the inevitable comparisons with the works of his teacher. Thus we find in Jenner’s work the same dual emphasis on musical tradition and independence emphasized both in Jenner’s prose writings and in the music of Brahms himself.
Sex-specific effects of maternal and postweaning high-fat diet on skeletal muscle mitochondrial respiration
Authors: Khamoui A. V. , Desai M. , Ross M. G. , Rossiter H. B. 
Published: August 2018

AbstractExposure to maternal over-nutrition in utero is linked with developmental programming of obesity, metabolic syndrome and cardiovascular disease in offspring, which may be exacerbated by postnatal high-fat (HF) diet. Skeletal muscle mitochondrial function contributes to substrate metabolism and is impaired in metabolic disease. We examined muscle mitochondrial respiration in male and female mice exposed to maternal HF diet in utero, followed by postweaning HF diet until middle age. After in utero exposure to maternal control (Con) or HF diet (45% kcal fat; 39.4% lard, 5.5% soybean oil), offspring were weaned to Con or HF, creating four groups: Con/Con (male/female (m/f), n=8/8), Con/HF (m/f, n=7/4), HF/Con (m/f, n=9/6) and HF/HF (m/f, n=4/4). Oxidative phosphorylation (OXPHOS) and electron transfer system (ETS) capacity were measured in permeabilized gastrocnemius bundles. Maternal HF diet increased fasting glucose and lean body mass in males and body fat percentage in both sexes (P⩽0.05). Maximal adenosine diphosphate-stimulated respiration (complex I OXPHOS) was decreased by maternal HF diet in female offspring (−21%, P=0.053), but not in male (−0%, P>0.05). Sexually divergent responses were exacerbated in offspring weaned to HF diet. In females, OXPHOS capacity was lower (−28%, P=0.041) when weaned to high-fat (HF/HF) v. control diet (HF/Con). In males, OXPHOS (+33%, P=0.009) and ETS (+42%, P=0.016) capacity increased. Our data suggest that maternal lard-based HF diet, rich in saturated fat, affects offspring skeletal muscle respiration in a sex-dependent manner, and these differences are exacerbated by HF diet in adulthood.