bluuebunny/crossref_metadata_2025_split huggingface dataset:
Error Analysis for Semilinear Stochastic Subdiffusion with Integrated Fractional Gaussian Noise
Authors: Wu Xiaolei , Yan Yubin 
Published: November 2024

We analyze the error estimates of a fully discrete scheme for solving a semilinear stochastic subdiffusion problem driven by integrated fractional Gaussian noise with a Hurst parameter H∈(0,1). The covariance operator Q of the stochastic fractional Wiener process satisfies ∥A−ρQ1/2∥HS < ∞ for some ρ∈[0,1), where ∥·∥HS denotes the Hilbert–Schmidt norm. The Caputo fractional derivative and Riemann–Liouville fractional integral are approximated using Lubich’s convolution quadrature formulas, while the noise is discretized via the Euler method. For the spatial derivative, we use the spectral Galerkin method. The approximate solution of the fully discrete scheme is represented as a convolution between a piecewise constant function and the inverse Laplace transform of a resolvent-related function. By using this convolution-based representation and applying the Burkholder–Davis–Gundy inequality for fractional Gaussian noise, we derive the optimal convergence rates for the proposed fully discrete scheme. Numerical experiments confirm that the computed results are consistent with the theoretical findings.
The Minimal Molecular Tree for the Exponential Randić Index
Authors: Bera Jayanta , Das Kinkar Chandra 
Published: November 2024

Topological indices are numerical parameters that provide a way to quantify the structural features of molecules using their graph representations. In chemical graph theory, these indices have been effectively employed to predict various physico-chemical properties of molecules. Among these, the Randić index stands out as a classical and widely used molecular descriptor in chemistry and pharmacology. The Randić index R(G) for a given graph G is defined as R(G)=∑vivj∈E(G)1d(vi)d(vj), where d(vi) represents the degree of vertex vi and E(G) is the set of edges in the graph G. Given the Randić index’s strong discrimination ability in describing molecular structures, a variant known as the exponential Randić index was recently introduced. The exponential Randić index ER(G) for a graph G is defined as ER(G)=∑vivj∈E(G)e1d(vi)d(vj). This paper further explores and fully characterizes the minimal molecular trees in relation to the exponential Randić index. Moreover, the chemical relevance of the exponential Randić index is also investigated.
Orange Peel Lactiplantibacillus plantarum: Development of A Mucoadhesive Nasal Spray with Antimicrobial and Anti-inflammatory Activity
Authors: Corazza Elisa , Pizzi Asia , Parolin Carola , Giordani Barbara , Abruzzo Angela , Bigucci Federica , Cerchiara Teresa , Luppi Barbara , Vitali Beatrice 
Published: November 2024

Background/Objectives: Due to the high frequency and severity of upper respiratory bacterial infections, probiotics could offer a new medical approach. We explored the antibacterial and anti-inflammatory properties of the new strain Lactiplantibacillus plantarum BIA and formulated a nasal spray. Methods: L. plantarum BIA was isolated from orange peel and taxonomically identified through 16S rRNA gene sequencing. Its antibacterial activity was tested against Pseudomonas aeruginosa, Streptococcus pyogenes, Bacillus subtilis, Escherichia coli, and Staphylococcus aureus, while anti-inflammatory potential was evaluated by Griess assay. BIA genome was fully sequenced and analyzed to assess its safety. BIA was formulated in a freeze-dried matrix, containing prebiotics and cryoprotectants, to be reconstituted with a polymer solution. Solutions containing two types of hydroxypropyl methylcellulose (HPMC) and hyaluronic acid were evaluated as resuspending media and compared in terms of pH, viscosity, and mucoadhesion ability. The biological activity of BIA formulated as nasal spray was verified together with the stability of the selected formulations. Results: L. plantarum BIA inhibited human pathogens’ growth and showed anti-inflammatory activity and a safe profile. In the best-performing formulation, the probiotic is lyophilized in 10% fructooligosaccharides, 0.1% ascorbic acid, and 0.5% lactose and reconstituted with HPMC high viscosity 1% w/v. This composition ensured the probiotic’s viability for up to six months in its dried form and one week after reconstitution. It also allowed interaction with the nasal mucosa, preserving its antimicrobial and anti-inflammatory activities. Conclusion: The developed nasal spray could become a promising formulation in the field of nasal infectious and inflammatory diseases.
Precision Medicine Proof-of-Concept Study of a TNF Inhibitor in FSGS and Treatment-Resistant Minimal Change Disease
Authors: Trachtman Howard , Modi Zubin J. , Ju Wenjun , Lee Edmond , Chinnakotla Silpa , Massengill Susan , Sedor John , Mariani Laura , Zhai Yan , Hao Wei , Desmond Hailey , Eddy Sean , Ramani Karthik , Spino Cathie , Kretzler Matthias 
Published: November 2024

Key Points

Precision medicine trials are feasible in patients with primary glomerular diseases.Patients with FSGS and the best-preserved kidney parenchyma demonstrated the most favorable biomarker response to short-term adalimumab treatment.Targeted therapies for FSGS are more likely to succeed during the course of disease when the injury pathway is activated and can be modified.

Background
FSGS and treatment-resistant minimal change disease (TR-MCD) are heterogeneous disorders with subgroups defined by distinct underlying mechanisms of glomerular and tubulointerstitial injury. A noninvasive urinary biomarker profile has been generated to identify patients with intrakidney TNF activation and to predict response to anti-TNF treatment. We conducted this proof-of-concept, multicenter, open-label clinical trial to test the hypothesis that in patients with FSGS or TR-MCD and evidence of intrarenal TNF activation based on their biomarker profile, short-term treatment with adalimumab would reverse the elevated urinary excretion of monocyte chemoattractant protein-1 (MCP-1) and tissue inhibitor of metalloproteinases 1.

Methods
Patients with FSGS or TR-MCD, eGFR >30 ml/min per 1.73 m2, urine protein:creatinine ratio ≥1.5 g/g, and age 6–80 years were eligible for this trial. Adalimumab, 20–40 mg, was administered through subcutaneous injection every 2 weeks for five doses. Participants were evaluated at weeks 0 (baseline), 2, 8, and 10. Excretion of urinary monocyte chemoattractant protein-1, urinary tissue inhibitor of metalloproteinases 1, urinary excretion of EGF, and plasma monocyte chemoattractant protein-1 were measured at each visit.

Results
Seven participants were enrolled, with median baseline urine protein:creatinine ratio 12.1 mg/mg (interquartile range [IQR], 2.2–18.6), serum albumin 2.4 g/dl (IQR, 2.0–2.8), and eGFR 57 ml/min per 1.73 m2 (IQR, 44–96). On the basis of self-report, they received all prescribed doses of adalimumab. The patients with the most favorable response on the basis of changes in urinary biomarkers had the best preserved kidney parenchyma based on urinary excretion of EGF.

Conclusions
Precision medicine trials are feasible in rare glomerular disorders. In this pilot study, adalimumab resulted in a heterogenous response of the candidate mechanistic-predictive biomarkers of TNF-mediated inflammation in patients with FSGS or TR-MCD. A reduction was seen in a subgroup of patients with preserved kidney parenchyma. The findings may reflect the challenge to reverse chronic injury at advanced stages of kidney disease or insufficient intrarenal target engagement with the intervention drug dose.

Clinical Trial registry name and registration number:

NCT04009668.
FAKTOR – FAKTOR YANG MEMPENGARUHI AUDIT DELAY PADA BANK KONVENSIONAL
Authors: Verene Barbie  , Luh Putu Puji Trisnawati  
Published: November 2024

Companies with strong financial conditions tend to complete their financial statement audits more quickly to enhance investor confidence. Investors need timely financial statements to assess business activities, performance, and profit potential over multiple periods. When there is a delay in publishing financial statements, it may hinder investors' decision-making and affect their perception of the company's financial condition. In conducting business activities, every company requires banking institutions. Banks have an important role in the economy and society, especially as a driver of fund flows and supporting economic activities. Banks are the link between those who have more funds (such as savers) and those who need funds (such as entrepreneurs or individuals who need loans). Using a quantitative research method, this study aims to analyze the impact of profitability, solvency, liquidity, and company size on audit delay in banks with core capital (KBMI) levels 3 and 4, as listed on the Financial Services Authority (OJK) website for the period 2017-2022. The quantitative method involves using secondary data, specifically financial statements, as the research data source. The sample was selected through non-probability sampling and purposive sampling techniques, resulting in 14 companies with a total of 84 data points. This study employs multiple linear regression analysis. Based on partial test results (t-test), it shows that solvency and liquidity do not affect audit delay, with significance values of 0.423 and 0.056, respectively, both of which are greater than 0.05. On the other hand, profitability and company size significantly influence audit delay, with significance values of 0.011 and 0.003, both of which are less than 0.05. The F-test, with a significance value of 0, indicates that profitability, solvency, liquidity, and company size collectively impact audit delay.
Electromobility in local administration offices of provincial cities in Poland – status at the end of 2022
Authors: Letkiewicz Andrzej , Krupska Joanna , Wentk Agnieszka 
Published: November 2024

ABSTRACT: The objective of this article is to investigate behaviours related to electromobility in terms of owned vehicle fleets and charging stations in local administration units, the role of zero-emission vehicles in building the image of the administration and the promotion of environmentally friendly behaviours among its employees as at the end of 2022. The completion of the objective was based on surveys of the data collected using the CATI technique from provincial offices (POs) and municipal offices (MOs)[1] of provincial cities. The survey showed that the primary means of transport owned by the entities surveyed are internal combustion engine vehicles. Of these, the largest group is made up of passenger cars – the average age of vehicles at the time of the survey was approx. eight years. In sum, the local administration in the provincial cities is approaching the target value established by law. The average share of BEVs in the passenger vehicle fleet is 9%. In terms of charging station ownership, there were three dominant patterns. There is a perception among respondents that a fleet of environmentally friendly vehicles builds a positive, pro-environmental image of the office, while in none of the offices was there any action to support the environmentally friendly behaviour of employees in terms of travelling to and from work.

[1] The survey covered local government administrative units in 16 cities where local government offices are located and involved provincial local government offices (POs) and municipal local government offices (MOs).
Особенности функционирования элементов национальной инновационной системы России
Authors: Л.П. Клеева 
Published: November 2024

В статье исследуются условия обеспечения эффективного научноинновационного процесса, включающие в себя требования к эффективному функционированию элементов национальной (региональной) инновационной системы и их взаимодействию, а также условия эффективной работы научноинновационной сферы в целом.
Annotation. The article studies the conditions ensure effective scientific innovation process, such as requirements for effective functioning elements of the national innovation system (regional) and also their interaction and effective conditions of work science and innovation sphere as a whole.
Исследование показателей развития рынка мобильной связи
Authors: Л.Е. Варшавский 
Published: November 2024

В статье проводится анализ показателей развития олигополистического рынка мобильной связи (на примере США) на средне и долгосрочную перспективу. С использованием методов теории динамических игр рассматриваются последствия превращения существующей квадрополии в триополию в результате возможного объединения компанийпровайдеров TMobile и Sprint. Путем компьютерного моделирования исследованы условия, при которых может быть повышена рыночная доля объединенной компании. Рассмотрены факторы, препятствующие дальнейшему широкомасштабному развертыванию мобильной связи в США.
Analysis of dynamics of indicators of the mobile wireless communication market over middle range and longrun periods is carried out (on the example of US market). On the basis of methods of dynamical games prospects and consequences of conversion of the current market quadropoly to triopoly are studied. With the help of computer modeling conditions favoring to increase of the market share of the new united carrier are determined. Factors hindering largescale development of mobile wireless communication are discussed.
Стратегия выстраивания долговой политики российских публичных компаний
Authors: С.И. Луценко 
Published: November 2024

Автор рассматривает особенности влияние ключевых факторов (финансовой гибкости, ликвидности и управленческой политики) на долговую стратегию финансирования российских публичных компаний. Особая роль отводится вкладу органа управления в определении долговой политики. В отличие от предыдущих исследований фокус исследования смещен в сторону совместного влияния ключевых факторов, направленных на корректировку структуры капитала в условиях непоследовательной экономической политики. Показатель управленческой политики позволяет оценить предупредительный мотив способность компании переключиться на внутренние источники финансирования (сохраняя денежные ресурсы для финансирования инвестиционных проектов). Исследуется влияние гипотезы предупредительного мотива, выдвинутой Д. Кейнсом. Публичные российские компании реализуют долговую политику, направленную на использовании внутренних ресурсов для финансирования инвестиционных проектов, с учетом их приоритетности. Менеджмент компаний следует логике предупредительного мотива сберегая денежные средства и направляя их на финансирование приоритетных инвестиционных проектов.
The author considers features influence of key factors (financial flexibility, liquidity and the management policy) on debt strategy of financing of the Russian public companies. The special role is taken away to the controls contribution to determination of a debt policy. Unlike the previous researches research focus is displaced towards joint influence of key factors on adjustment of capital structure in the conditions of inconsistent economic policy. The indicator of work of company management allows to estimate precautionary motive the capability of the company to be switched to internal sources of financing (savings of money resources for financing of investment projects). The Author researches hypothesis of precautionary motive pushed by J. Keynes. The public Russian companies implement the debt policy directed on use of internal resources for financing of investment projects, taking into account them prioritization. Management of the companies follows logic of precautionary motive saving up money resources and directing them on financing of priority investment projects.
Проблемы социально-экономического развития страны после завершения активной фазы борьбы с коронавирусом
Authors: А.Е. Варшавский 
Published: November 2024

В работе обосновывается необходимость решения внутренних проблем российской экономической системы. В их числе - совершенствование социально-экономической политики, изменение кредитно-финансовой системы; защита собственных интересов России во внешней торговле; выбор приори-тетных направлений социально-экономического развития, в первую очередь ускорение развития об-рабатывающих производств при отказе от преимущественной ориентации на цифровизацию в услови-ях разрушения электронной промышленности и производства компьютерной техники;, развитие сфе-ры НИОКР и ускорение инновационной деятельности; восстановление и полноценное развитие отрас-лей, обеспечивающих эффективное реагирование в случае чрезвычайных ситуаций, в том числе си-стемы здравоохранения; развитие сельского хозяйства; переориентация жилищного строительства; развитие транспортной инфраструктуры; сокращение чрезмерного неравенства доходов населения и пространственного неравенства; повышение уровня разработки долгосрочной стратегии социально-экономического развития страны. Подчеркивается возрастание роли государственного управления в условиях кризиса и необходимость системного подхода для повышения уровня подготовки офици-альных документов.
In the paper it is shown the need to solve internal problems of the Russian economic system. In their number are the following: improving socio-economic policy, changing the credit and financial system; protecting Russia's own interests in foreign trade; selecting priority areas for socio-economic development, primarily accelerating the development of manufacturing industries, while rejecting the primary focus on digitalization in the face of the destruction of the electronic industry and computer technology; developing R&D sector and accelerating innovation; restoration and full development of industries that provide an effective response to emergencies, including the health system; development of agriculture; reorientation of housing construction; development of transport infrastructure; reduction of excessive income inequality and spatial inequality; increasing the level of development of the long-term strategy for socio-economic development of the country. The increasing role of the governmental control in the crisis and the need for a system approach to improve the level of preparation of official documents are emphasized.
О положении дел с ядерной безопасностью в России
Authors: В.И. Рыбаченков 
Published: November 2024

В работе показано, что за последние 20 лет Россия кардинально улучшила ядерную безопасность, осуществив модернизацию систем учета, контроля и физической безопасности ядерных материалов более, чем на 300 подведомственных Росатому и Минобороны объектах. Подобные меры имели целью обеспечение сохранности как расщепляющихся материалов, так и арсенала ядерного оружия и представляли собой первую линию обороны против незаконного ядерного оборота, чреватого ядерным распространением и терроризмом. Одновременно был усилен потенциал второй линии обороны (КПП таможенных служб), обеспечивающей пресечение незаконного ядерного оборота ядерных материалов через национальные границы. Ускорению указанных работ способствовало активное американское содействие в рамках утвержденной конгрессом США программы Нанна – Лугара.
It is shown that during the last 20 years Russia accomplished cardinal refurbishment of accounting, control and physical protection systems at more than 300 facilities belonging to Rosatom and Ministry of Defense. Such measures were directed towards assuring safekeeping of fissile materials and nuclear weapons and composed the first line of defense against nuclear smuggling fraught with nuclear proliferation and terrorism. At the same time was reinforced the potential of the second line of defense ((customs check points) assuring suppression of nuclear smuggling at national borders. The implementation of the above mentioned measures was accelerated by active American assistance in the framework of Nunn-Lugar program approved by the US Congress.
Малые предприятия и инновационная активность предприятий химической промышленности России
Authors: А.М. Хахладжиян 
Published: November 2024

В работе проанализирован состав предприятий химической отрасли по их размеру в современных условиях. В химической индустрии крупный бизнес во многом определяет потенциал отрасли, но отмечено значительное место малых предприятий, наблюдается тенденция их увеличения, особенно в таком виде деятельности как производство резиновых и пластмассовых изделий. По классификации инновационной активности предприятий основные виды деятельности химической отрасли представлены в группе среднетехнологичных отраслей высокого и низкого уровня. Доля инновационно активных предприятий по производству химических веществ и химических продуктов меньше, чем в целом по предприятиям среднетехнологичных отраслей высокого уровня. Для реализации потенциала химической промышленности необходимо повышение эффективности использования сырьевой базы, техническое перевооружение и стимулирование инновационной активности предприятий.
The paper analyzes the composition of chemical enterprises in terms of their size in modern conditions. In the chemical industry, large business largely determines the potential of the industry, but a significant place of small enterprises has been noted, there is a tendency to increase them, especially in this type of activity as the production of rubber and plastic products. According to the classification of innovative activity of enterprises, the main types of activities of the chemical industry are represented in the group of medium-tech industries of high and low levels. The share of innovatively active enterprises for the production of chemicals and chemical products is less than in general for enterprises of high-level medium-tech industries. To realize the potential of the chemical industry, it is necessary to increase the efficiency of using the raw material base, technical re-equipment and stimulate the innovative activity of enterprises.
Современные тенденции развития полупроводниковой промышленности
Authors: Л.Е. Варшавский 
Published: November 2024

В статье проводится краткий анализ состояния мирового рынка полупроводниковой продукции в последние годы. Рассматриваются причины возникшего на рынке дефицита продукции и особенности производственного цикла в отрасли. Дается описание основных характерных черт глобализации в производстве полупроводников. Рассматриваются перспективные сегменты рынка полупроводниковой продукции в ближайшей перспективе.
The article provides a brief analysis of the state of the world market for semiconductor products in recent years. The causes of the shortage of products on the market and the specifics of the production cycle in the industry are considered. A description of the main characteristic features of globalization in the production of semiconductors is given. Some perspective segments of the semiconductor market in the nearest future are considered.
Экономико-статистический анализ тенденций развития суперкомпьютеров
Authors: Л.Е. Варшавский 
Published: November 2024

В статье проводится экономико-статистический анализ тенденций изменения параметров высокопроизводительных суперкомпьютеров. Исследуется влияние ввода наиболее мощных устройств на динамику показателей отдельных групп суперкомпьютеров из списка 500 наиболее производительных. Исследуются тенденции изменения энергоэффективности.
The article provides an economic and statistical analysis of trends in the parameters of high-performance supercomputers. The influence of the introduction of the most powerful devices on the dynamics of the performance of individual groups of supercomputers from the list of the Top500 is investigated. Trends in energy efficiency are being investigated.