bluuebunny/crossref_metadata_2025_split huggingface dataset:
Our experience in the podological analysis of children with motor disorders (20 cases)
Authors: Mansi Zied , Aymen Ben Mahmoud , Abdelkader Tounsi , Ahmed Mahmoudi , Wajdi Chermiti , Ali Haggui , Bacem Zaidi 
Published: November 2024

Introduction and Importance: Pediatric patients with neuromotor disorders frequently experience various podiatric conditions. The effectiveness and implications of treatments like orthotics and insoles in this demographic are not thoroughly understood, highlighting a significant gap in podiatric research and clinical practice.Case Presentation: This observational study analyzed 20 pediatric patients with neuromotor disorders. The focus was on common foot conditions such as ingrown toenails and hyperhidrosis, and their association with treatments like orthotics, insoles, and surgical interventions like Achilles tendon lengthening.Clinical Discussion: Statistical analysis using chi-square tests revealed significant associations. Notably, orthotic use was linked to a higher incidence of ingrown toenails (χ² = 5.69, p = 0.017). In contrast, insole usage correlated with increased hyperhidrosis (χ² = 4.44, p = 0.035). Additionally, a significant tendency for orthotic use was observed in patients who underwent Achilles tendon lengthening (χ² = 8.15, p = 0.017). The study also highlighted the prevalence of brittle nails and hyperkeratosis among the participants.Conclusion: The findings emphasize the critical role of podiatrists in the management of foot conditions in pediatric neuromotor disorder patients. While interventions like orthotics are generally beneficial, they may also exacerbate or contribute to other conditions, necessitating regular and careful podiatric monitoring. The study advocates for future research with larger sample sizes and controlled study designs to further validate and expand upon these observations.
Nekrotizirajući enterokolitis – prikaz slučajeva i pregled literature
Authors: Bašković Marko , Župančić Božidar , Car Andrija , Višnjić Stjepan , Ježek Davor 
Published: November 2024

Nekrotizirajući enterokolitis je gastrointestinalna bolest novorođenačke dobi opasna za život. Do dana današnjeg patogeneza bolesti nije jasna, ali je prihvaćeno da je multifaktorska. Rizični čimbenici za nastanak ove bolesti su u prvom redu nedonošenost iniska porođajna masa. Bolest se dijagnosticira na temelju kliničke slike upotpunjene radiološkim i laboratorijskim nalazima. Načinliječenja ovisi o težini kliničke slike i stadiju bolesti. U većini slučajeva dostatno je simptomsko i antimikrobno liječenje uz praćenjelaboratorijskih i radioloških parametara. Novorođenčad s teškim oblikom bolesti i perforacijom crijeva zahtijeva hitno kirurško liječenje. Kako bismo približili ovo stanje, prikazali smo troje pacijenata liječenih u Klinici za dječje bolesti Zagreb u 2016. godini.
Provedba cijepljenja protiv HPV-a u Republici Hrvatskoj
Authors: Posavec Marija 
Published: November 2024

Dostupnost cjepiva protiv humanog papiloma virusa (HPV) generacijama mladih omogućila je zaštitu od karcinoma u odraslojdobi. U Hrvatskoj je cjepivo protiv HPV-a registrirano 2007. godine. Hrvatsko društvo za školsku i sveučilišnu medicinu Hrvatskog liječničkog zbora provelo je u 2016. godini istraživanje online upitnikom. Rezultati upućuju na brojna i različita iskustva specijalistaškolske medicine u organizaciji, provedbi i odazivu na cijepljenje.Razlozi odbijanja cijepljenja protiv HPV-a su mnogobrojni, no istraživanja i iskustva upućuju na to da su najčešći sumnja u pouzdanost cjepiva, preispitivanje njegove učinkovitosti, povezivanje cijepljenja s rizičnim spolnim ponašanjem, koncept besplatnog, preporučljivog, dobrovoljnog cjepiva uz obvezan informirani pristanak kao novitet u provedbi cijepljenja u Hrvatskoj. Mogućnost cijepljenja protiv HPV-a u Hrvatskoj postoji više od desetljeća, no još i danas je veliki izazov za profesionalce u pogledu informiranja ieduciranja roditelja, djece i mladih o mogućnosti i važnosti prevencije bolesti uzrokovanih HPV-om jednostavnim, pouzdanim iučinkovitim postupkom – cijepljenjem.
Pristup predškolskom djetetu s ponavljajućom sipnjom – kada postaviti dijagnozu astme i kako liječiti bolesnika?
Authors: Štefanović Iva Mihatov , Vrsalović Renata , Čičak Biserka , Lesar Tatjana , Ribičić Rebeka 
Published: November 2024

Sipnja je jedan od najčešćih respiratornih simptoma u predškolskoj dobi. U većine djece sipnja je vezana isključivo za virusne infek cijegornjih dišnih putova i s vremenom je prolazna, no trećina djece s ponavljajućom sipnjom ima postavljenu dijagnozu astme u školskoj dobi. Prema smjernicama stručnih društava ponavljajuća sipnja se u predškolskoj dobi najčešće klasifi cira u fenotipove,ovisno o učestalosti simptoma i njihovoj povezanosti s određenim okidačima. Upalna patogeneza fenotipova sipnje u predškolskojdobi zasad nije poznata, ali vjerojatno je riječ o različitim upalnim mehanizmima. Većina djece s ponavljajućom sipnjom u predškolskoj dobi može se liječiti samo bronhodilatatorima. Prema smjernicama Europskog respiratornog društva protuupalnu terapiju treba započeti u bolesnika koji imaju učestale simptome i tešku kliničku sliku. Mjerenje objektivnih parametara kao što su plućnafunkcija i hiperreaktivnost dišnih putova otežano je zbog nesuradnje, tako da je uvođenje terapije i dobar klinički odgovor vjerojatnonajpouzdaniji put za dijagnozu astme. U ovom trenutku ne postoje strategije liječenja koje bi modifi cirale tijek bolesti i spriječile razvoj perzistentne sipnje odnosno astme.
Obostrana prirođena dislokacija koljena udružena s obostranim razvojnim poremećajem kuka – prikaz bolesnika
Authors: Miličić Gordana , Šimić Marijana , Bojić Davor , Vlaić Josip , Ribičić Omislav , Vrdoljak Ozren , Antičević Darko , Matić Ida , Miličić Marko 
Published: November 2024

Prirođena dislokacija koljena je relativno rijetka deformacija, a pogotovo udružena s deformacijom drugih zglobova. Djevojčica uovom prikazu, rođena je s obostranom dislokacijom koljena i obostranim razvojnim poremećajem kuka u smislu iščašenja. Prvi pregled u ortopedskoj ambulanti obavljen je 21. dan nakon rođenja. Učinjena je radiološka i ultrazvučna dijagnostika i genetska obrada.Nisu nađeni elementi Larsenova sindroma kao ni artrogripoze. Djevojčica je liječena trakcijom na vertikalnom okviru i sadrenim redresmanom oba koljena. Nakon repozicije kukova aplicirao se aparat Hilgenreiner. Tek nakon repozicije oba kuka omogućila se redresmanom repozicija i puna fl eksija koljena. Nakon stabilizacije kukova i koljena aplicirani su remenčići prema Pavliku, koji su nošenidva mj. Liječenje je trajalo do sedam mj. života djevojčice a svi postupci su praćeni ultrazvukom i RTG snimkama. Praćenje još traje.
Mikrodelecija 8q23.3-q24.11 povezana sa sindromima Langer-Giedion i Cornelia de Lange-4
Authors: Ivankov Ana-Maria , Bobinec Adriana , Boban Ljubica , Sansović Ivona , Barišić Ingeborg 
Published: November 2024

Mikrodelecija kromosomske regije 8q23.3-q24.11 povezuje se sa sindromom Langer-Giedion ili trihorinofalangealnim sindromomtipa II., rijetkim genetičkim poremećajem uzrokovanim prvenstveno delecijom gena TRPS1 i EXT1. Fenotip je sukladan trihorinofalangealnom sindromu tipa 1, ali uključuje i višestruke osteohondrome tipa 1. Kako je riječ o sindromu delecije susjednih gena, klinička slika varira ovisno o veličini deletirane regije. U navedenoj se regiji nalazi i gen RAD21, čije se heterozigotne delecije i muta cijepovezuju sa sindromom Cornelia de Lange-4. U ovom radu prikazujemo dva bolesnika s delecijom koja obuhvaća kromosomskuregiju 8q23.3-q24.11, kod kojih je molekularnom i citogenetskom analizom utvrđeno da imaju dva različita poremećaja – sindromLanger Giedion i sindrom Cornelia de Lange-4
Klinička slika konverzivnog poremećaja u hitnoj pedijatrijskoj službi: prikaz triju bolesnica
Authors: Santrić Lena , Richter Darko , Begovac Ivan 
Published: November 2024

Konverzivni poremećaj u adolescenata može imati dramatičnu kliničku prezentaciju te ga je u prvi mah teško razlikovati od organskih ili od drugih psihijatrijskih bolesti. Prikazujemo tri bolesnice u dobi od 11 do 13 godina koje su dovedene u hitnu pedijatrijskuambulantu pod slikom neepileptičkih psihogenih napadaja. Zbog dramatične kliničke prezentacije, odsutnosti kontakta i sličnosti spravim epileptičkim napadajima, primijenjene su reanimacijske mjere te antikonvulzivna terapija. Tek naknadno, detaljnom dijagnostičkom obradom, isključeno je organsko podrijetlo simptoma. Psihološkim testiranjem te pregledom dječjeg i adolescentnog psihijatra postavljena je dijagnoza konverzivnog poremećaja, a liječenje i praćenje nastavljeno je na dječjoj i adolescentnojpsihijatriji. Kako bi se izbjegle nedoumice te primjena rizičnih i nepotrebnih terapijskih postupaka, u svakodnevnoj hitnoj pedijatrijskoj praksi potrebno je misliti i na moguće neepileptičke psihogene napadaje.
Pasivno pušenje i poremećaji dišnog sustava u djece
Authors: Pavić Ivan , Vlahović Irma Golmajer , Pavić Ivana , Čurlin Mirela 
Published: November 2024

Iako je brojnim istraživanjima dokazan štetan utjecaj pasivnog pušenja na dišni sustav djece, činjenica je da značajan broj roditeljai dalje izlaže svoju djecu duhanskom dimu. Glavni cilj ovog preglednog članka je upozoriti na štetne posljedice pasivne izloženostiduhanskom dimu na dišni sustav u dječjoj dobi te utvrditi koji bi bili mogući mehanizmi njihovog nastanka. Brojnim epidemiološkimistraživanjima dokazano je da su djeca izložena pasivnom pušenju sklonija infekcijama dišnog sustava, imaju povećanu učestalostporemećaja plućne funkcije i astme, kao i statistički značajno nižu motoričku spremnost i fi zičku kondiciju od djece čiji roditelji nisupušači. Dokazano je da čak djeca majki koje su pušile tijekom trudnoće kasnije u djetinjstvu imaju povećani rizik za pojavu bolestidišnog sustava. Podatci o štetnim učincima duhanskog dima trebali bi pomoći u javnozdravstvenim aktivnostima usmjerenim prema smanjenju izloženosti djece pasivnom pušenju i svih negativnih utjecaja izloženosti pasivnog pušenja na zdravlje djece.
Study on the chiroptical properties of carbon dots based on citric acid and formamide with the addition of various chiral molecules
Authors: Stepanidenko Evgeniia A. , Vedernikova Anna A. , Mitroshin Alexander M. , Arefina Irina A. , Parfenov Petr S. , Cherevkov Sergei A. , Ushakova Elena V. 
Published: November 2024

Subject of study. The study focuses on luminescent carbon nanoparticles, specifically carbon dots, based on citric acid, formamide, and various chiral molecules. Aim of study. The aim is to assess the influence of chiral molecules used in the synthesis of carbon dots on optical transitions in the long-wavelength spectral region and to investigate the mechanism underlying the circular dichroism signal of these nanoparticles. Method. Carbon dot samples were synthesized using two methods: (i) a one-step solvothermal synthesis of carbon dots from citric acid, formamide, and various chiral molecules and (ii) a two-step method involving the solvothermal synthesis of achiral carbon dots from citric acid and formamide, followed by surface treatment with L-cysteine. Absorption and luminescence spectroscopy methods were employed to study the chemical structure and optical properties of the carbon dots. The chiroptical properties of the obtained samples were analyzed using circular dichroism spectroscopy. Main results. The addition of various chiral molecules to a mixture of precursors during one-step synthesis enabled the fabrication of carbon dots with different chemical compositions, including variations in surface groups and types of emission centers in the spectral region of 350–700 nm. The use of L-phenylglycine and L-tryptophan in the one-step synthesis was shown to lead to the formation of nanoparticles with optical transitions in both short- and long-wavelength regions of the spectrum. The addition of L-glutathione during the one-step synthesis resulted in the formation of carbon dots with short-wavelength emission, while the addition of L-cysteine did not alter the emission characteristics of achiral carbon dots based on citric acid and formamide. The optical properties of the chiral carbon dots obtained using the two-step synthesis method with L-cysteine remained unchanged compared with those of the achiral carbon dots synthesized from citric acid and formamide. The circular dichroism spectra of all the samples showed a signal at ∼250nm, which was attributed to the derivatives of the chiral precursors attached to the surface of the nanoparticles, irrespective of the preparation method. Practical significance. Chiral carbon dots hold promise in biomedicine as sensors, luminescent biomarkers, and other applications due to their biocompatibility and non-toxicity. The results obtained in this work will serve as a foundation for the further fabrication and investigation of chiral carbon nanoparticles with long-wavelength luminescence.
Photodynamic inactivation strategies for maximizing antifungal effect against Sporothrix spp. and Candida albicans in an in vitro investigation
Authors: Rocha Amanda Regina , Inada Natalia Mayumi , da Silva Ana Paula , Bagnato Vanderlei Salvador , Buzzá Hilde Harb 
Published: November 2024

Background
Sporotrichosis is a zoonotic disease caused by the dimorphic fungus Sporothrix spp., leading to skin lesions that can, in some cases, progress and result in the death of infected individuals. Candida albicans is another fungus involved in several skin, oral, and vaginal mucosal infections. Fungal diseases are concerning due to increasing incidence and the limited variety of antifungal classes available for treatment. Furthermore, antifungal medications can cause various side effects, exacerbated by their prolonged use during infection treatment. There is a need to explore alternatives to conventional drugs that are effective, fast, and safe in combating sporotrichosis. This study aimed to achieve in vitro elimination of the fungi Sporothrix brasiliensis and Sporothrix schenckii through Photodynamic Inactivation (PDI), using curcumin as a photosensitizer and in combination with antifungal agents used in the treatment of sporotrichosis.

Methodology
Yeasts of Candida albicans, Sporothrix brasiliensis, and Sporothrix schenckii were subjected to Photodynamic Inactivation (PDI) using light at a wavelength of 450 ± 10 nm, irradiance of 35 mW/cm2, delivering a fluence of 31.5 J/cm2, with curcumin as the photosensitizer at doses ranging from 0.75 to 150 μg/mL. After determining the Minimum Inhibitory Concentration (MIC) values of the antifungal drugs itraconazole, ketoconazole, and potassium iodide, sub-MIC doses of these antifungals were combined with sub-MIC doses of curcumin in a new PDI session.

Conclusion
Photodynamic inactivation is a promising technique in the treatment of sporotrichosis, as well as its combination with antifungals. The combination of curcumin in concentrations ranging from 0.75 g/mL a 7.5 g/mL with sub-MIC concentrations of itraconazole, ketoconazole, and potassium iodide was able to completely inactivate the fungi C. albicans, S. brasiliensis and S. schenckii, indicating that PDI may increase the effectiveness of antifungals. However, further studies are needed to establish protocols for future clinical applications.
Long-term outcome for patients with distal radius fractures treated with volar locking plates versus percutaneous wires
Authors: Wretö Linnea , Fornander Lotta 
Published: November 2024

Background
Fractures of the distal radius are the most common fractures of the upper extremity. The choice of surgical method has been debated and studies show that short-term differences, in favour of volar locking plates, are indistinguishable at 1 year follow-up. Few studies have investigated long-term outcomes beyond one year. The aim of this study was to investigate long-term (6–10 years) patient-reported outcomes after distal radius fracture surgery, and to determine how fracture pattern/complexity (Buttazzoni fracture type) affects the results.

Methods
303 patients surgically treated for a distal radius fracture, from 2012–2016 were included. The questionnaires used were PRWE, Quick-DASH and EQ-5D. Previous studies have shown that fracture type influences the choice of surgical method and therefore fracture type was adjusted for in the statistical analysis.

Results
We found that patients treated with K-wires had significantly better Quick-DASH scores (p <0.05) and a lower degree of pain (PRWE pain scale) (p <0.05) than patients treated with volar locking plates. There was no difference between the two groups regarding the remaining outcome measures for any Buttazzoni type of fracture.

Conclusion
On the basis of these results, K-wires can be considered an equivalent option to locking plates because of equal or better long-term outcomes, lower costs, and shorter operation times.
Healthcare provider-related perceptions toward deprescribing inappropriate medications among older adult outpatients
Authors: Rababa Mohammad Jamil , Al Ghazo Ali 
Published: November 2024

Objectives
To examine healthcare provider-related perceptions toward deprescribing inappropriate medications among older adults.

Methods
A cross-sectional, correlational study used a convenience sample of outpatient older adults to measure their perception toward deprescribing using a Patient’s Perceptions of Deprescribing (PPoD), which include 57 multiple-choice questions related to patients’ sociodemographic data, health, medicines, healthcare providers, and experience of care provided by the clinic. Data were collected by a graduate nursing student from one pharmacy in a public hospital, five days per week, via in-person interviews.

Results
Data were analyzed for 200 participants. The level of patient collaboration with their primary care providers (PCPs) is linked to their trust in PCPs, beliefs about medication use, PCP knowledge, and medication concerns (p < .0001). Patient involvement in medication deprescribing decision-making is also associated with trust in PCPs and willingness to stop a medication (p < .0001). Additionally, trust in PCPs is related to patient involvement in decision-making, PCP knowledge, general health, collaboration with PCPs, and receiving conflicting information about a medicine (p = .010). Lastly, PCP medication knowledge is associated with trust in PCPs, views on the importance of medicines, medication concerns, seeking help with medicines, interactions with clinical pharmacists, and being advised by a clinical pharmacist to discontinue medication (p < .0001).

Conclusions
The study found that older adults’ trust in their PCP, collaboration with their PCP, involvement in the decision-making of deprescribing, and knowledge about medication are associated with clinical and medicine-related factors. Therefore, PCPs should discuss the benefits of deprescribing inappropriate medications to prevent long-term side effects. Future studies should focus on the effectiveness of evidence-based deprescribing protocols for older adults.
Association between systemic immunity-inflammation index and glucose regulation in non-diabetic population: A population-based study from the NHANES (2005–2016)
Authors: Qing Wenxiang , Qian Yujie 
Published: November 2024

Background
To investigated the link between the systemic immunity-inflammation index (SII), a new inflammatory biomarker, and the risk of abnormal glucose regulation in non-diabetic population.

Methods
Using data from the 2005–2016 National Health and Nutrition Examination Survey (NHANES), we conducted a cross-sectional study on non-diabetic adults with data on SII and glucose regulation markers. We analyzed the relationship between SII and indicators of glucose regulation, including fasting plasma glucose, fasting insulin, hemoglobin A1c, oral glucose tolerance test (OGTT), and states of abnormal glucose regulation like impaired glucose tolerance (IGT), insulin resistance, and prediabetes.

Results
Adjusting for confounders, higher SII levels were significantly associated with a higher OGTT and a greater likelihood of IGT (OR = 2.673, 95% CI: 1.845, 3.873). In subgroup analysis, participants without hyperlipidemia in the highest SII quartile had a 240% higher odds of IGT compared to those in the lowest quartile (OR = 3.407, 95%CI: 1.995, 5.820), an association not observed in those with hyperlipidemia (p for interaction < 0.05).

Conclusions
SII emerges as a useful biomarker for identifying IGT in non-diabetic individuals, specifically in those without hyperlipidemia.
Taxonomia para pagamentos por serviços ambientais:
Authors: Scarpeline de Castro Biancca , Frickmann Young Carlos Eduardo 
Published: November 2024

O presente artigo tem como objetivo considerar a diversidade de situações na discussão sobre o desenho das iniciativas de pagamentos por serviços ambientais (PSA), com foco no estabelecimento do pagamento a ser realizado para os provedores desses serviços. A hipótese central é que a base de cálculo do pagamento dos serviços ambientais deve ser diferenciada de acordo com o local e o grupo social beneficiário. Em particular, argumenta-se que metodologias baseadas no custo de oportunidade do trabalho devem ser pensadas para beneficiar agentes que não sejam proprietários da terra ou têm ações não relacionadas ao seu uso, como forma de compensar o tempo e esforço demandado pelas práticas sustentáveis que se deseja estimular. O artigo é exploratório e pautado por revisão bibliográfica da literatura nacional e internacional sobre PSA e sua relação com a política ambiental. O principal resultado é a elaboração de uma taxonomia simplificada que diferencia os modelos de pagamento em sistemas voltados para propriedades rurais privadas com objetivo de produção comercial e as demais situações onde a terra não é privada ou o objetivo do PSA não está relacionado ao uso da terra. Também se argumenta que sistemas de PSA financiados por recursos privados tendem a se concentrar no primeiro caso, enquanto o uso de recursos públicos deve ser primordialmente direcionado para o segundo caso. Essa diferenciação pode ser importante para a implementação da Lei nº 14.119, que institui a Política Nacional de Pagamento por Serviços Ambientais no Brasil.
Construção de Consenso na proteção do patrimônio socioambiental:
Authors: Damasceno Mara Livia Moreira , Teixeira Maryana Fonseca 
Published: November 2024

A Praia do Futuro, em Fortaleza/CE apresenta necessidade de uma requalificação e reordenamento das barracas em termos ambientais e urbanísticos e em virtude da complexidade do cenário que envolve a Praia do Futuro, é necessário utilizar uma forma de solução de conflitos que atenda às necessidades das múltiplas partes envolvidas neste contexto. Assim, este estudo tem como objetivo geral analisar a possível adequação da ferramenta da Construção de Consenso para a resolução do conflito referente a qualificação da Praia do Futuro - CE. Para isso, elegeu-se como específicos, a necessidade de (a) verificar como é possível construir acordos em conflitos envolvendo múltiplas partes; (b) examinar as razões para a requalificação da Praia do Futuro; (c) identificar a possibilidade de utilização de mecanismos de solução de conflitos não regulamentados no Brasil. Para o desenvolvimento do trabalho, desenvolveu-se pesquisa de natureza qualitativa, do tipo bibliográfica, com coleta documental e com análise descritiva. Como resultado, entendeu-se que a Construção de Consenso figura hoje como o método mais adequado para a resolução de conflitos que envolvam múltiplas partes, como o da requalificação da Praia do Futuro, proporcionando a participação dos interessados na construção de um plano executável por todos os envolvidos.