bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Radiographic Outcomes of Tibiotalocalcaneal or Pantalar Arthrodesis Using a Novel Lateral Locking Plate
Authors: Rutherford Tyler , Campbell John , Cerrato Rebecca , Jeng Clifford 
Published: September 2018

Category: Ankle Introduction/Purpose: For patients suffering from severe ankle and hindfoot arthritis or deformity, tibiotalocalcaneal (TTC) or pantalar arthrodesis may be the best option to achieve a plantigrade and painless foot. These fusions are typically fixed with a retrograde intramedullary nail, a lateral side plate, or screws alone. Theoretically, the advantages of a lateral side plate applied via a trans-fibular approach include the use and the multiple points of fixation available in the tibia, talus, and calcaneus. The results of a novel side plate construct with a unique screw hole that extends underneath the calcaneus are presented in this study. A large diameter screw can be inserted retrograde through this inferior hole to engage the medial tibial cortex and provide axial compression across the ankle and subtalar joints. Methods: This study retrospectively evaluated 39 patients that underwent a tibiotalocalcaneal (TTC) or pantalar arthrodesis using this novel lateral plate fixation technique by one of three fellowship trained surgeons at a tertiary referral center. Patients with less than a one year follow up were excluded. Thirty-nine patients were identified between 2012 and 2016. Two patients were deceased from other causes, 2 had a below the knee amputation due to chronic pain, and 9 were lost to follow up. Pre- and postoperative General Health and Wellness (SF-12) and Revised Foot Function Index scores were obtained. Study subjects were seen for a clinical evaluation and final post-operative x-rays. The Shapiro-Wilk test was used to test for normality. The paired student’s t-test was used to compare pre- and post-surgical outcome measures. Results: Twenty-six patients were included in the study group. Mean follow up time was 34.42 ± 12.94 months. The SF-12 score was 32.2 ± 10.22 (physical) and 54.8 ± 10.7 (mental) before surgery, and 41.35 ± 9.21 (p < 0.01) and 56.5 ± 7.47 (p = 0.73) at final follow-up, respectively. The FFI score was 106 ± 32.69 before surgery and 53.94 ± 24.14 after surgery (p = 0.06). Eighteen patients were satisfied or very satisfied with the outcome of the surgery (70%). CT confirmation of joint fusion was obtained in all 26 patients. Twenty out of the 26 patients demonstrated fusion of all joints (77%). There were 2 ankle, 1 subtalar, and 1 talonavicular nonunions. In total, 44 of 48 total joints were fused (91%). Conclusion: Tibiotalocalcanceal and pantalar arthrodesis using a novel lateral plate for the treatment of complex deformity and severe osteoarthritis demonstrated acceptable fusion rates considering the number of patients with high risk factors for nonunion in this study group. Complications included fractures at the proximal end of the plate construct and persistent neurapraxia which was well tolerated. Patients reported significant improvements in SF-12 clinical scores at final 34 month follow-up.
Chronic Symptomatic Ankle Avulsion Fracture
Authors: Wang Bibo 
Published: September 2018

Category: Ankle Introduction/Purpose: Persistent pain and instability following inversion or eversion injuries of the ankle is not rare. Besides injury of lateral or medial ligaments, avulsion fracture of lateral or medial malleolus could be found in some cases. The avulsion fracture may result in nonunion and/or ligamentous laxity which could lead to chronic ankle pain. The purpose of this study was to evaluate the intraoperative findings and long-term outcomes of patients of symptomatic ankle avulsion fracture. Methods: 23 patients of ankle avulsion fracture along with chronic ankle pain and instability were studied. Tenderness and swollen at lateral and/or medial gutter were found and radiographic images were taken for the diagnosis. After at least 6 months of unsuccessful non-operative treatment, all patients underwent surgery of osseous fragments excision and anatomic ankle ligaments reconstruction. AOFAS-AH and VAS Score were given to assess the outcomes of surgery. Results: There were 21 males and 9 females among the patients. The average age of the patients was 24.6 years (range, 18-45 years) at the time of injury and 27.3 years (range, 18-46) at the time of surgery, indicating a mean delay in diagnosis and/or treatment of 2.7 years. At a mean follow-up of 2.6 years (range, 1 to 5.2 years), the average AOFAS-AH Score increased from 72.5 to 93.2 out of 100 (P<0.05), the average VAS score decreased from 6.2 to 1.2 (P<0.05). Conclusion: For those patients of ankle avulsion fracture presenting with chronic ankle pain and instability, surgical excision of the bony fragment combined with reconstruction of ankle ligaments were effective in eliminating pain, restoring ankle stability, and helping return to the pre-injury functional level.
A synthetic promoter for multi-stage expression to probe complementary functions of Plasmodium adhesins
Authors: Klug Dennis , Kehrer Jessica , Frischknecht Friedrich , Singer Mirko 
Published: September 2018

ABSTRACT
Gene expression of malaria parasites is mediated by the apicomplexan Apetala2 (ApiAP2) transcription factor family. Different ApiAP2s control gene expression at distinct stages in the complex life cycle of the parasite, ensuring timely expression of stage-specific genes. ApiAP2s recognize short cis-regulatory elements that are enriched in the upstream/promoter region of their target genes. This should, in principle, allow the generation of ‘synthetic’ promoters that drive gene expression at desired stages of the Plasmodium life cycle. Here we test this concept by combining cis-regulatory elements of two genes expressed successively within the mosquito part of the life cycle. Our tailored ‘synthetic’ promoters, named Spooki 1.0 and Spooki 2.0, activate gene expression in early and late mosquito stages, as shown by the expression of a fluorescent reporter. We used these promoters to address the specific functionality of two related adhesins that are exclusively expressed either during the early or late mosquito stage. By modifying the expression profile of both adhesins in absence of their counterpart we were able to test for complementary functions in gliding and invasion. We discuss the possible advantages and drawbacks of our approach.
This article has an associated First Person interview with the first author of the paper.
Unified platform for multimodal voxel-based analysis to evaluate tumour perfusion and diffusion characteristics before and after radiation treatment evaluated in metastatic brain cancer
Authors: Coolens Catherine , Driscoll Brandon , Foltz Warren , Svistoun Igor , Sinno Noha , Chung Caroline 
Published: September 2018

Objective:
Early changes in tumour behaviour following stereotactic radiosurgery) are potential biomarkers of response. To-date quantitative model-based measures of dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) MRI parameters have shown widely variable findings, which may be attributable to variability in image acquisition, post-processing and analysis. Big data analytic approaches are needed for the automation of computationally intensive modelling calculations for every voxel, independent of observer interpretation.

Methods:
This unified platform is a voxel-based, multimodality architecture that brings complimentary solute transport processes such as perfusion and diffusion into a common framework. The methodology was tested on synthetic data and digital reference objects and consequently evaluated in patients who underwent volumetric DCE-CT, DCE-MRI and DWI-MRI scans before and after treatment. Three-dimensional pharmacokinetic parameter maps from both modalities were compared as well as the correlation between apparent diffusion coefficient (ADC) values and the extravascular, extracellular volume (Ve). Comparison of histogram parameters was done via Bland–Altman analysis, as well as Student’s t-test and Pearson’s correlation using two-sided analysis.

Results:
System testing on synthetic Tofts model data and digital reference objects recovered the ground truth parameters with mean relative percent error of 1.07 × 10−7 and 5.60 × 10−4 respectively. Direct voxel-to-voxel Pearson’s analysis showed statistically significant correlations between CT and MR which peaked at Day 7 for Ktrans (R = 0.74, p &lt;= 0.0001). Statistically significant correlations were also present between ADC and Ve derived from both DCE-MRI and DCE-CT with highest median correlations found at Day 3 between median ADC and Ve,MRI values (R = 0.6, p &lt; 0.01) The strongest correlation to DCE-CT measurements was found with DCE-MRI analysis using voxelwise T10 maps (R = 0.575, p &lt; 0.001) instead of assigning a fixed T10 value.

Conclusion:
The unified implementation of multiparametric transport modelling allowed for more robust and timely observer-independent data analytics. Utility of a common analysis platform has shown higher correlations between pharmacokinetic parameters obtained from different modalities than has previously been reported.

Advances in knowledge:
Utility of a common analysis platform has shown statistically higher correlations between pharmacokinetic parameters obtained from different modalities than has previously been reported.
Patient preferences for involvement in health service development
Authors: Finn Vincent , Stephenson John , Astin Felicity 
Published: September 2018

Background: patient involvement in the design, planning and delivery of health services is acknowledged to be a local and national priority. Aims: to improve service quality through a quality improvement initiative to explore patient preferences for involvement in health services design, planning and delivery. Methods: a questionnaire was developed to: assess patient preferences for involvement in hospital service development; and explore differences in responses between patient subgroups. Findings: 162 patients were recruited. Most were positive about being engaged in all service developments, not just those used personally. Involvement through questionnaires with infrequent email communication was favoured over attendance at public meetings. Time was a greater barrier to being involved than distance or remuneration. Conclusion’ Patients valued involvement in health service development, but finding free time during working hours was difficult. There were no differences in preferences for involvement between subgroups defined by gender, ethnicity, home situation or health.
SPACE MISSION DEFINITION BASED ON ANALYTICAL HIERARCHY PROCESS (AHP) METHOD
Authors: Naseh Hassan 
Published: September 2018

Generally, missions of remote sensing satellites are divided into three types: monitoring missions, recognition missions and surveillance missions. These missions need the Sun Synchronous Orbits (SSOs) or Multi-Sun Synchronous Orbits (MSSOs) in order to perform the operations. These SSOs and MSSOs have many requirements that make deciding the best type a multi-criteria decision problem. To this end, the Analytical Hierarchy Process (AHP) methodology is utilized to decide the orbit type in the remote sensing satellites missions. Therefore, the objective in the above methodology is to reach the orbit in the minimum amount of time and with the minimum cost (SSOs or MSSOs). The criterions are remote sensing missions, and the alternatives in the AHP methodology are the SSOs and MSSOs. In the conclusion, the results of methodology are presented and evaluated.
Mental illness media and the paradox of ‘productivity’ in Elementary and Limitless
Authors: Brayton Sean 
Published: September 2018

Abstract
This article examines representations of mental illness in North American network television. It is particularly drawn to the CBS police procedurals Elementary (2012–present) and Limitless (2015) as distinct but overlapping stories of mental illness, addiction and intellectual labour. Though depression, drug addiction and anxiety disorders are treated differently in each series, Elementary and Limitless offer complementary narratives of occupational therapy that equate work with mental well-being. While they seem to present a positive image of mentally ill characters with meaningful jobs, Elementary and Limitless measure mental fitness by one’s capacity to work in the same industries often linked to mental illnesses in the first place, resulting in a paradox of productivity. Here the television programmes, much like occupational therapy, tend to overlook critical questions about the socio-economic underpinnings of psychological disorders and encourage viewers to understand the links between mental illness and work in rather myopic ways.
Transgression – identification – interaction: Blu-ray bonus features and Supernatural’s cult status
Authors: Fuchs Michael 
Published: September 2018

Abstract
Being ‘cultish’ is not a feature which is inherent in a given media text. Rather, this quality is attributed to the text in question over time, usually due to the development of a passionate fan community around it. Nevertheless, media producers are well aware of means which help increase – or in some cases even produce – the cult status of their products. This article dissects the role the bonus features included in Supernatural’s Blu-ray releases play in the cultification of the series. As this article demonstrates these special features primarily function as a means of tightening the bond between the fan community and the show’s creative team.
The road to Negan: Governance and power in The Walking Dead
Authors: Howe Andrew , Evans Sean 
Published: September 2018

Abstract
In Robert Kirkman’s graphic novel The Walking Dead (2003–present), a zombie apocalypse serves as the backdrop against which the survivors make the practical and moral decisions that will determine their fate. The struggle is less about combating the undead than maintaining a civilized, moral imperative and reformulating a micro-society from the ashes of previous civilization. Leadership and decisionmaking become critical in situations where the wrong choice can result in destruction. The television adaptation offers a rare glimpse into a world where some of the fundamental features of civilization – government, kinship, culture – are simultaneously and completely enveloped in chaos. In the midst of a complete breakdown of structure, power vacuums occur and are inevitably filled, most notably in the early parts of the series by Rick Grimes and Shane Walsh, friends and former law enforcement officers who model very different visions of power and governance. This article explores power structures and hierarchy in The Walking Dead from two disciplinary perspectives – historical/cultural and psychological – and focuses upon the clash of competing hierarchal structures and leadership styles that develop as the survivors band together and begin to seek out islands of safety from zombies and other humans alike. The zombie apocalypse is thus a backdrop against which to project the real story: the power dynamics within a micro-society undergoing tremendous stress, and what these dynamics indicate about the conflicted nature of power and identity.
From ambivalence to acceptance: Representations of trans embodiment on American television
Authors: Lafrance Marc , Manicom Jay , Bardwell Geoff 
Published: September 2018

Abstract
Boasting some of the highest ratings in American cable television history, FX’s six-season dramatic series Nip/Tuck (2003–10) features more trans characters than any other show of its kind. Focusing on its regularly recurring trans woman character, Ava Moore, we argue that Nip/Tuck’s representations of trans embodiment are complex, contradictory and, above all, ambivalent. More specifically, we claim that the show portrays medically-assisted transition not only as a large-scale crisis in the order of things but also as a path to personal prosperity and success. In doing so, we demonstrate that the former is articulated through themes of incest, infertility, fraudulence and monstrosity while the latter is articulated through themes of beauty, intelligence, resilience and social mobility. Having presented our analysis of how Nip/Tuck represents sex reassignment and those who undergo it, we then turn to a critical consideration of how a more recent dramatic series, Orange is the New Black (2013–present), portrays the trans trajectory. Widely understood to represent a kind of ‘transgender tipping point’, Orange is the New Black can be seen as a useful index of how trans people are portrayed in present-day televisual culture. Through our consideration of these portrayals, we think critically about whether popular media representations of sex reassignment have changed since Nip/Tuck and, if so, in what ways.
From ‘pop’ nostalgia to millennial modernity: Bugs as an ‘Avengers for the 1990s’
Authors: Oldham Joseph 
Published: September 2018

Abstract
This article examines the 1990s adventure series Bugs (1995–99), whilst also exploring broader transformations in British television thrillers and nostalgic programming. First, I position the series’ origin as a response to the popularity of 1960s adventure series repeats on the BBC in the 1990s. I argue, that the nostalgic impulse of Bugs itself did not manifest in visual terms, as in more conventional 1960s pastiches, but was instead at a narrative level. The series dispensed with contemporaneous trends towards more psychologised characters and serialised narratives in favour of a self-consciously ‘retro’ rejection of ‘depth’. Yet I also explore other ways in which it adapted the adventure series for the 1990s. These included reworking the spy agency as a small business enterprise for the ‘dotcom’ age, reinventing alienating surveillance technology as the user-friendly gadget, glamorizing neo-liberalism through exoticizing London’s redeveloped Docklands, and presenting terrorism as a leading existential threat for the post-Cold War era. I argue that whilst Bugs represented a dead end for an ‘innocent’ model of nostalgic drama, through many of the latter characteristics it stands as an unacknowledged influence on a later generation of stylish, issue-led ‘War on Terror’ thriller series.
In flag-rante: Julia Gillard and the infamous ‘flag scene’ in ABC’s At Home with Julia
Authors: Stevenson Ana 
Published: September 2018

Abstract
In 2011, the Australian Broadcasting Corporation financed and produced a controversial sitcom based on the life, characteristics, and politics of incumbent Prime Minister Julia Gillard. At Home with Julia (2011) examined Gillard’s private life by fictionalizing her de facto relationship with partner Tim Mathieson. Before, during, and after it aired, the series became a media spectacle as print, digital and broadcast journalists debated the propriety of the parody/satire. Media hype peaked in response to a fleeting scene in which the main characters appear cuddling under the Australian flag. Drawing on scholarship about postfeminism, this article examines the representation of single/unmarried women in popular culture and the characterization of political women in television dramas. The media commentary surrounding At Home with Julia denounced the ‘flag scene’ in the strongest terms, yet this reportage also conveyed an underlying unease towards the series’ candid depiction of sexuality. Most significantly, journalists collectively failed to adequately distinguish between Gillard, the prime minister, and ‘Julia’, the fictional character. Such a failure, this article suggests, enabled and excused the media’s subsequent and far more visceral sexualization of Australia’s first female prime minister. Although the public clearly understood the fictional premise of At Home with Julia, the Australian media fabricated a ‘sex’ scandal that came to be read onto the body of Gillard herself.
Seeking academic help: A case study of peer brokering interactions
Authors: Lee Sherrie 
Published: September 2018

Abstract
The literature often depicts international students as deficient due to poor English language skills and limited participation in class, thus positioning them as lacking in agency or habitually weak. This article reframes international students as resourceful learners by focusing on their academic learning through brokering, that is, help-seeking social interactions. Understood as part of informal learning practices, brokering interactions take place when students seek assistance with unfamiliar academic texts and practices from brokers, that is, those who are able to bridge cultural and knowledge gaps. The article reports on research that investigated brokering practices among ten international English as an Additional Language (EAL) students in their initial semester of study at a New Zealand university. In particular, the article examines the brokering interactions between two participants, Linda, a first-year student, and her broker Emily, a fellow Mainland Chinese student who provided information and advice about various academic tasks and situations. A conversation analytic approach that views brokering as asymmetrical knowledge positions is used to analyse twelve episodes of brokering interactions in Chinese that took place through WeChat, a mobile phone application. Initial analysis reveals that the dynamics of brokering interactions between Linda and Emily were characterized by a display of social solidarity, even as seeker and broker negotiated their knowledge positions over information or advice offered by the broker. The article concludes that peer brokering between same language speakers provides a collegial space in which students exercise agency by utilizing sociolinguistic resources. Thus educational institutions should recognise the importance of international students’ informal academic learning and increase opportunities for EAL students to build and enhance their social connections with peers as part of a holistic approach towards academic support.
Return to Mecca: Balik-Islam among Filipino migrants in Singapore
Authors: Rosario Teresita Cruz-del 
Published: September 2018

Abstract
The narrative of the globalization of labour and the demands of the labour market dominates most of the scholarship on Filipino migration, emphasizing their contribution to the Philippine economy via remittances even while these migrants endure difficulties working in forbidding terrain – a companion narrative of sacrifice and endurance. What remains below the surface, however, is the enchantment with the discovery of a new world-view among them. Balik-Islam, the ‘return’ to Islam, is part of the imaginary among Filipinos who have travelled, lived and worked across territories, connecting them to Mecca, both physically and spiritually. While their labour skills brought them to the Middle East and other Muslim-majority countries, their journey expanded into the discovery of meanings beyond their labour value. In this article, I regard Mecca as an imaginary among Filipino travellers who have somehow bridged the connection between their lost Islamic heritage and their labour, the latter allowing them to reclaim this heritage as authentic to their identity. In this article, I discuss the reconfiguration of Mecca as ‘home’, ‘redemption’ and ‘resurrection’ among itinerant Filipinos: first, as a salve to constant dislocations in an impersonal and aggressive global economy, second, as a source of salvation from indulgence in otherwise forbidden behaviour in foreign territories where the codes of behaviour back home have been transgressed (e.g., adultery) and third, as a spiritual resurrection in which a return to Mecca erases the past and provides a new path, a new identity and a rebirth. However, a more instrumentalist view of conversion, one that depicts conversion as part of a rational strategy to ease the tensions in intimate relations between Catholics and Muslims, also forms part of this article. In this latter dimension, Mecca is an ‘absent’ place bereft of spiritual meaning and serves to reinforce the homelessness of the migration experience.