bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behaviour of small-scale turbulence in the turbulent/non-turbulent interface region of developing turbulent jets
Authors: Breda M. , Buxton O. R. H. 
Published: September 2019

Tomographic particle image velocimetry experiments were conducted in the near and intermediate fields of two different types of jet, one fitted with a circular orifice and another fitted with a repeating-fractal-pattern orifice. Breda & Buxton (J. Vis., vol. 21 (4), 2018, pp. 525–532; Phys. Fluids, vol. 30, 2018, 035109) showed that this fractal geometry suppressed the large-scale coherent structures present in the near field and affected the rate of entrainment of background fluid into, and subsequent development of, the fractal jet, relative to the round jet. In light of these findings we now examine the modification of the turbulent/non-turbulent interface (TNTI) and spatial evolution of the small-scale behaviour of these different jets, which are both important factors behind determining the entrainment rate. This evolution is examined in both the streamwise direction and within the TNTI itself where the fluid adapts from a non-turbulent state, initially through the direct action of viscosity and then through nonlinear inertial processes, to the state of the turbulence within the bulk of the flow over a short distance. We show that the suppression of the coherent structures in the fractal jet leads to a less contorted interface, with large-scale excursions of the inner TNTI (that between the jet’s azimuthal shear layer and the potential core) being suppressed. Further downstream, the behaviour of the TNTI is shown to be comparable for both jets. The velocity gradients develop into a canonical state with streamwise distance, manifested as the development of the classical tear-drop shaped contours of the statistical distribution of the velocity-gradient-tensor invariants $\mathit{Q}$ and $\mathit{R}$. The velocity gradients also develop spatially through the TNTI from the irrotational boundary to the bulk flow; in particular, there is a strong small-scale anisotropy in this region. This strong inhomogeneity of the velocity gradients in the TNTI region has strong consequences for the scaling of the thickness of the TNTI in these spatially developing flows since both the Taylor and Kolmogorov length scales are directly computed from the velocity gradients.
On pathological properties of fixed point algebras in Kirchberg algebras
Authors: Suzuki Yuhei 
Published: September 2019

AbstractWe investigate how the fixed point algebra of a C*-dynamical system can differ from the underlying C*-algebra. For any exact group Γ and any infinite group Λ, we construct an outer action of Λ on the Cuntz algebra 𝒪2whose fixed point algebra is almost equal to the reduced group C*-algebra${\rm C}_{\rm r}^* (\Gamma)$. Moreover, we show that every infinite group admits outer actions on all Kirchberg algebras whose fixed point algebras fail the completely bounded approximation property.
A National Conversation About Race? Political Discussion Across Lines of Racial and Partisan Difference
Authors: Eveland William P. , Appiah Osei 
Published: September 2019

AbstractDialogue about race-based topics is essential to combat prejudice, foster mutual understanding, and improve race relations. This study describes the extent to which political conversations—especially those about race-related topics—are taking place within and across racial and political groups. This national survey with a Black oversample found racially diverse discussion networks to be more likely among Blacks than Whites, but politically diverse networks to be more likely among Whites than Blacks. Blacks were more likely than Whites to talk about race-related topics such as police treatment of Blacks (and less likely about several topics not explicitly tied to race), but by no means did Whites entirely avoid race-related topics, even in their same-race discussions. Moreover, there was evidence that discussion in cross-race dyads affected the mix of topics Whites and Blacks discussed, revealing the potential for cross-race interaction to alter political agendas. Rather than being less likely to talk about police treatment of Blacks with Blacks, Whites were more likely to discuss this topic when in mixed-race dyads, while Blacks talked about it less often with Whites than with other Blacks. Findings are discussed in the context of political disagreement and intergroup contact theory.
New data on the microvertebrate fauna from the Upper Jurassic or lowest Cretaceous of Ksar Metlili (Anoual Syncline, eastern Morocco)
Authors: Lasseron Maxime , Allain Ronan , Gheerbrant Emmanuel , Haddoumi Hamid , Jalil Nour-Eddine , Métais Grégoire , Rage Jean-Claude , Vullo Romain , Zouhri Samir 
Published: September 2019

AbstractThe Middle Jurassic – Early Cretaceous period witnessed the emergence of some major representatives of modern continental vertebrate groups (stem lissamphibians, squamates, therian mammals and birds) and angiosperms, at a time when fragmentation of Pangaea was underway. The successive Moroccan microvertebrate faunas of Ksar Metlili (?Berriasian) and Guelb el Ahmar (Bathonian) from the Anoual Syncline significantly improve our poor knowledge of Gondwanan and especially African palaeobiodiversity at this time. They are among the richest known from the Mesozoic of Gondwana, and are well placed in northwestern Africa to record faunal interchanges with Laurasia. Here we focus on the Ksar Metlili fauna, first documented in the 1980s and most recently resampled in 2010, which produced 24 541 microremains representing 47 species of 8 main groups (Chondrichthyes, Actinopterygii, Sarcopterygii, Lissamphibia, Lepidosauromorpha, Testudinata, Archosauromorpha and Synapsida). It includes remarkable taxa: the oldest stem boreosphenidan mammals from Gondwana, probably some of the last non-mammaliaform cynodonts, a basal ornithischian, possibly freshwater teleosaurid crocodylomorphs, and some of the rare occurrences of choristoderes and albanerpetontids in Gondwana. Comparison of the Ksar Metlili fauna with that of Guimarota (Kimmeridgian, Portugal) further provides evidence of numerous shared taxa of Laurasian affinities, in contrast to the occurrence of few taxa with Gondwanan affinities. This suggests complex palaeobiogeographical relationships – implying both vicariance and dispersal events – of North Africa within Gondwana at the Jurassic–Cretaceous transition. Finally, the faunal similarities with the Guelb el Ahmar fauna question the Cretaceous age of the Ksar Metlili fauna, suggesting an alternative possible Late Jurassic age.
Billingshausen of the Antarctic?
Authors: Bulkeley Rip 
Published: September 2019

AbstractThe Russian naval officer Faddej Faddeevich Bellingshausen began life with a slightly different surname, in his case ‘Billingshausen’. It is possible to work out roughly when the Russian surname ‘Bellinsgauzen’ was chosen. Considerations prompting the selection of that particular Russian version can also be suggested.
When a linguistic variable doesn’t vary (much): The subjunctive mood in a conservative variety of Acadian French and its relevance to the actuation problem
Authors: Comeau Philip 
Published: September 2019

AbstractThis study considers the subjunctive mood in one of the most conservative varieties of Acadian French, that spoken in the Baie Sainte-Marie region in the Canadian province of Nova Scotia. A number of claims made in the literature are considered: whether the subjunctive mood is undergoing loss, whether it expresses semantic meaning, and whether it is lexically-conditioned. Unlike most spoken varieties of French where the subjunctive is argued to be a linguistic variable (i.e., it varies with other moods), the results for Baie Sainte-Marie show that it varies very little. The analysis reveals that the few cases of variation can be accounted for by formal theoretical approaches to the subjunctive where this mood is argued to express modality. With limited variation, the subjunctive is not showing signs of loss. These findings suggest that the subjunctive is not part of a linguistic variable and so is not subject to inherent variability. I further argue that the retention of the imperfect subjunctive in this variety, along with a tense concordance effect, can help us understand why the subjunctive became a linguistic variable in other varieties of French, which ultimately contributes to our understanding of the actuation problem.
Recent surge of ready meals in South Korea: can they be healthy alternatives?
Authors: Kim So-young , Kim Suyoun 
Published: September 2019

AbstractObjective:The present study analysed and compared the nutritional qualities of private brand (PB) and national brand (NB) ready meal (RM) products in South Korea.Design:Data on RM products were collected via a food information database (EatSight) between February and May of 2017. A total of ninety-one PB products from a leading discount store chain in South Korea and 415 NB products were selected and divided into four main categories of ‘refrigerated soups/stews’, ‘refrigerated noodles’, ‘frozen rice/noodles’ and ‘frozen dumplings’. Nutritional information was extracted for each product and analyses were performed to compare nutritional differences.Setting:South Korea.Participants:A total of 506 RM products.Results:PB products explained the highest percentage of refrigerated RM products while NB products occupied the highest percentage of frozen ones. Notably, main PB and NB products showed evident nutritional problems. Among PB products, refrigerated soups/stews were significantly higher in energy, fat, Na, saturated fat andtrans-fat. Likewise, in the case of NB products, frozen rice/noodles were significantly higher in Na and saturated fat. Particularly, overall Na contents were high. When the Korean guidance on traffic-light labelling was applied, a mere 0·2 and 5·9 % of total RM products showed all four and three green lights, respectively. Meanwhile, those with no green lights accounted for 42·3 %.Conclusions:Although it is difficult to draw a definitive conclusion on the comparative nutritional qualities due to the lack of consistency in the results, the study suggests that there is room to improve the nutritional qualities of overall RM products.
Beyond NP: Quantifying over Answer Sets
Authors: AMENDOLA GIOVANNI , RICCA FRANCESCO , TRUSZCZYNSKI MIROSLAW 
Published: September 2019

AbstractAnswer Set Programming (ASP) is a logic programming paradigm featuring a purely declarative language with comparatively high modeling capabilities. Indeed, ASP can model problems in NP in a compact and elegant way. However, modeling problems beyond NP with ASP is known to be complicated, on the one hand, and limited to problems in $\[\Sigma _2^P\]$ on the other. Inspired by the way Quantified Boolean Formulas extend SAT formulas to model problems beyond NP, we propose an extension of ASP that introduces quantifiers over stable models of programs. We name the new language ASP with Quantifiers (ASP(Q)). In the paper we identify computational properties of ASP(Q); we highlight its modeling capabilities by reporting natural encodings of several complex problems with applications in artificial intelligence and number theory; and we compare ASP(Q) with related languages. Arguably, ASP(Q) allows one to model problems in the Polynomial Hierarchy in a direct way, providing an elegant expansion of ASP beyond the class NP.
Online Event Recognition from Moving Vehicles: Application Paper
Authors: TSILIONIS EFTHIMIS , KOUTROUMANIS NIKOLAOS , NIKITOPOULOS PANAGIOTIS , DOULKERIDIS CHRISTOS , ARTIKIS ALEXANDER 
Published: September 2019

AbstractWe present a system for online composite event recognition over streaming positions of commercial vehicles. Our system employs a data enrichment module, augmenting the mobility data with external information, such as weather data and proximity to points of interest. In addition, the composite event recognition module, based on a highly optimised logic programming implementation of the Event Calculus, consumes the enriched data and identifies activities that are beneficial in fleet management applications. We evaluate our system on large, real-world data from commercial vehicles, and illustrate its efficiency.
Partial Compilation of ASP Programs
Authors: CUTERI BERNARDO , DODARO CARMINE , RICCA FRANCESCO , SCHÜLLER PETER 
Published: September 2019

AbstractAnswer Set Programming (ASP) is a well-known declarative formalism in logic programming. Efficient implementations made it possible to apply ASP in many scenarios, ranging from deductive databases applications to the solution of hard combinatorial problems. State-of-the-art ASP systems are based on the traditional ground&solve approach and are general-purpose implementations, i.e., they are essentially built once for any kind of input program. In this paper, we propose an extended architecture for ASP systems, in which parts of the input program are compiled into an ad-hoc evaluation algorithm (i.e., we obtain a specific binary for a given program), and might not be subject to the grounding step. To this end, we identify a condition that allows the compilation of a sub-program, and present the related partial compilation technique. Importantly, we have implemented the new approach on top of a well-known ASP solver and conducted an experimental analysis on publicly-available benchmarks. Results show that our compilation-based approach improves on the state of the art in various scenarios, including cases in which the input program is stratified or the grounding blow-up makes the evaluation unpractical with traditional ASP systems.
Domain-Independent Cost-Optimal Planning in ASP
Authors: SPIES DAVID , YOU JIA-HUAI , HAYWARD RYAN 
Published: September 2019

AbstractWe investigate the problem of cost-optimal planning in ASP. Current ASP planners can be trivially extended to a cost-optimal one by adding weak constraints, but only for a given makespan (number of steps). It is desirable to have a planner that guarantees global optimality. In this paper, we present two approaches to addressing this problem. First, we show how to engineer a cost-optimal planner composed of two ASP programs running in parallel. Using lessons learned from this, we then develop an entirely new approach to cost-optimal planning,stepless planning, which is completely free of makespan. Experiments to compare the two approaches with the only known cost-optimal planner in SAT reveal good potentials for stepless planning in ASP.
Tri-beam slot antenna array based on substrate integrated waveguide (SIW) technology
Authors: Wang Zhenye , Dai Xiwang , Sun Wen 
Published: September 2019

AbstractA novel tri-beam slot antenna array based on substrate integrated waveguide (SIW) technology is proposed in this paper. The beam forming network is a 3 × 3 Butler matrix consisted of three couplers and four phase shifters. A 1.76 dB coupler is located between two 3 dB couplers, with this arrangement; the input signal can be divided into three parts with the same amplitude and certain phase differences. Two parallel slots are cut off broadside of SIW transmission line, which constitutes the basic unit of the antenna array. A 3 × 2 slot antenna array is connected with this circuit. Three beams with the directions of −30, 0 and 30° are produced when different ports are excited, respectively. The S parameters, radiation patterns, and gains are simulated and measured, which show that it can be a candidate for multi-beam wireless communication systems.
Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis
Authors: Bang In Hyuk , Kwon Oh Kwang , Hao Lihua , Park Dami , Chung Myung-Ja , Oh Byung-Chul , Lee Sangkyu , Bae Eun Ju , Park Byung-Hyun 
Published: September 2019

Abstract
The active spliced form of X-box-binding protein 1 (XBP1s) is a key modulator of ER stress, but the functional role of its post-translational modification remains unclear. Here, we demonstrate that XBP1s is a deacetylation target of Sirt6 and that its deacetylation protects against ER stress-induced hepatic steatosis. Specifically, the abundance of acetylated XBP1s and concordant hepatic steatosis were increased in hepatocyte-specific Sirt6 knockout and obese mice but were decreased by genetic overexpression and pharmacological activation of Sirt6. Mechanistically, we identified that Sirt6 deacetylated a transactivation domain of XBP1s at Lys257 and Lys297 and promoted XBP1s protein degradation through the ubiquitin-proteasome system. Overexpression of XBP1s, but not its deacetylation mutant 2KR (K257/297R), in mice increased lipid accumulation in the liver. Importantly, in liver tissues obtained from patients with nonalcoholic fatty liver disease (NAFLD), the extent of XBP1s acetylation correlated positively with the NAFLD activity score but negatively with the Sirt6 level. Collectively, we present direct evidence supporting the importance of XBP1 acetylation in ER stress-induced hepatic steatosis.
RAF kinases are stabilized and required for dendritic cell differentiation and function
Authors: Riegel Kristina , Schlöder Janine , Sobczak Marco , Jonuleit Helmut , Thiede Bernd , Schild Hansjörg , Rajalingam Krishnaraj 
Published: September 2019

AbstractRAF kinases (ARAF, BRAF, and CRAF) are highly conserved enzymes that trigger the RAF-MEK1/2-ERK1/2 (MAPK) pathway upon activation of RAS. Despite enormous clinical interest, relatively little is known on the role of RAFs in mediating immune responses. Here, we investigated the role of RAF kinases and MEK1/2 in dendritic cells (DCs), the central regulators of T cell-mediated antitumor immune responses and the adaptive immune system. We demonstrate that RAF kinases are active and stabilized at their protein levels during DC differentiation. Inhibition of RAF kinases but not MEK1/2 impaired the activation of DCs in both mice and human. As expected, DCs treated with RAF inhibitors show defects in activating T cells. Further, RAF and MEK1/2 kinases are directly required for the activation and proliferation of CD4+T cells. Our observations suggest that RAF and MEK1/2 have independent roles in regulating DC function that has important implications for administering RAF–MAPK inhibitors in the clinics.
LINC01232 exerts oncogenic activities in pancreatic adenocarcinoma via regulation of TM9SF2
Authors: Li Qian , Lei Chengbin , Lu Changliang , Wang Jingye , Gao Min , Gao Wei 
Published: September 2019

AbstractPancreatic adenocarcinoma (PAAD), one of the most prevailing malignant tumors in digestive system, is identified as one of the main culprits of cancer-associated mortality. Despite long intergenic non-protein coding RNA 1232 (LINC01232) is found to be upregulated in TCGA PAAD tissues and associated with poor prognosis, the potential of LINC01232 in PAAD progression still needs more explorations. In this study, LINC01232 was chosen to be the research object in PAAD cellular processes. Functionally, loss-of function assays were carried out and the experimental results indicated that suppression of LINC01232 hindered the deterioration of PAAD by affecting cell proliferation and migration. Furthermore, relationship between LINC01232 and its nearby gene transmembrane 9 superfamily member 2 (TM9SF2) was investigated. The same expression pattern of TM9SF2 in TCGA PAAD samples was observed. It was found that upregulation of LINC01232 could be a crucial factor for the dysregulation of TM9SF2. Mechanistically, LINC01232 recruited EIF4A3 to boost TM9SF2 mRNA stability. Besides, our findings demonstrated that the transcriptional activation of LINC01232 and TM9SF2 was mediated by SP1. Therefore, we concluded that LINC01232 executed carcinogenic properties in PAAD progression via regulation of TM9SF2. In conclusion, this study was the first to unveil the role and molecular mechanism of LINC01232, suggesting LINC01232 as a promising molecular target for pancreatic cancer treatment.
Chromosomal instability of circulating tumor DNA reflect therapeutic responses in advanced gastric cancer
Authors: Chen Zuhua , Zhang Cheng , Zhang Mengqi , Li Beifang , Niu Yunyun , Chen Limeng , Yang Jing , Lu Sijia , Gao Jing , Shen Lin 
Published: September 2019

AbstractGastric cancer is characterized by chromosomal instability. In this study, we investigated chromosomal instability quantified by copy number instability (CNI) score of circulating tumor DNA (ctDNA) during the drug treatment in advanced gastric cancer (AGC). A total of 55 pretherapeutic plasmas from 55 AGC patients and 75 plasmas during drug treatment of 26 AGC patients were collected. Plasma ctDNA was extracted and assessed by whole-genome sequencing (WGS) for somatic copy number alteration (SCNA), and according to which we calculated the CNI scores. We next assessed the correlations between chromosomal instability and therapeutic response. The cutoff value of chromosomal instability was defined as the mean + SD of the CNI scores (56.60) in cfDNA of plasmas from 100 healthy people. For 55 enrolled cases, chromosomal instability was observed in 27 (49%) prior to drug treatment, whose response rate (59%, 16/27) was higher than in 28 patients with stable chromosomes (32%, 9/28, P = 0.043). We also observed that CNI scores fluctuated during treatment in 26 patients. Specifically, the CNI scores in 93% (14/15) of patients sensitive to drug treatment reduced to the level of chromosomal stability and the CNI scores in 52% (13/25) of patients resistant to treatment elevated again. For ctDNA with developed resistance, the SCNA patterns were identical to those before treatment, whereas the CNI scores were lower than the pretherapeutic scores. We found that chromosomal instability based on ctDNA could predict and monitor therapeutic response in gastric cancer, although validation in a larger cohort will be necessary.
DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway
Authors: Cui Xichun , Liu Xin , Han Qicai , Zhu Jianming , Li Jianhao , Ren Zhigang , Liu Liwen , Luo Yanbing , Wang Zhifang , Zhang Dandan , Fan Yingzhong , Zhang Da , Dong Gang 
Published: September 2019

AbstractHepatoblastoma (HB) is the most common hepatic neoplasm in childhood and the therapeutic outcomes remain undesirable due to its recurrence and metastasis. Increasing evidence shows that dipeptidase 1 (DPEP1) has pivotal function in tumorigenesis in multiple tumors. However, the expression pattern, biological function, and underlying mechanism of DPEP1 in HB have not been reported. Here we showed that DPEP1 was significantly upregulated and was associated with poor prognosis in HB patients. In vitro and in vivo assays indicated that silencing DPEP1 significantly suppressed HB cell proliferation, migration, and invasion, while DPEP1 overexpression exhibited the opposite effect. In addition, we identified that DPEP1 was a direct target of microRNA-193a-5p (miR-193a-5p). Functional experiments demonstrated that overexpression of miR-193a-5p significantly inhibited cell proliferation and invasion of HB cells, while the inhibitory effect could be reversed by DPEP1 overexpression. Moreover, miR-193a-5p was decreased in HB tumor tissues and associated with a poor clinical prognosis. Mechanistically, our results indicated that the miR-193a-5p/DPEP1 axis participated to the progression of HB via regulating the PI3K/Akt/mTOR (phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin) signaling. In conclusion, our findings suggest that the miR-193a-5p /DPEP1 axis might be a good prognostic predictor and therapeutic target in HB.