bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression
Authors: Wu Min‐Hua , Chiu Yi‐Fang , Wu Wen‐Jun , Wu Pei‐Lien , Lin Ching‐Yi , Lin Chia‐Liang , Hsieh Yi‐Hsien , Liu Chung‐Jung 
Published: September 2018

AbstractTo improve the clinical outcome of tumor chemotherapy, more effective combination treatments against tumor metastasis and recurrence are required. Licochalcone A (LicA) is the root of Glycyrrhiza inflata and has been reported to possess anti‐inflammatory, antimicrobial, and antitumor effects. Sorafenib (Sor), a multikinase inhibitor, is used to treat patients with solid tumors such as advanced hepatocellular carcinoma (HCC). However, the synergistic effects of LicA and Sor on the metastasis of human HCC cells have not been reported. We found that LicA and Sor did not have cytotoxic effects or arrest growth in human SK‐Hep‐1 and Huh‐7 cells. In addition, treatment with LicA or Sor alone inhibited migration and invasion in human SK‐Hep‐1 and Huh‐7 HCC cells. Furthermore, cotreatment with LicA and Sor synergistically inhibited the migration and invasion of HCC cells and significantly inhibited uPA protein expression. Notably, cotreatment of LicA and Sor synergistically and significantly downregulated MKK4‐JNK expression. Through tail vein injection in nude mice, the aforementioned cotreatment synergistically suppressed SK‐Hep‐1 cell‐mediated lung metastasis. These findings first revealed the synergistic effects of LicA and Sor cotreatment against human HCC cells, further suggesting that beneficial effects on tumor regression could be confirmed through prospective clinical trials.
Holographic three-point correlators in the Schrodinger/dipole CFT correspondence
Authors: Georgiou George , Zoakos Dimitrios 
Published: September 2018

AbstractWe calculate, for the first time, three-point correlation functions involving “heavy” operators in the Schrodinger/null-dipole CFT correspondence at strong coupling. In particular, we focus on the three-point functions of the dilaton modes and two “heavy” operators. The heavy states are dual to the single spin and dyonic magnon, the single spin and dyonic spike solutions or to two novel string solutions which do not have an undeformed counterpart. Our results provide the leading term of the correlators in the largeλexpansion and are in perfect agreement with the form of the correlator dictated by non-relativistic conformal invariance. We also specify the scaling function which can not be fixed by using conformal invariance.
Heterologous production of a new lasso peptide brevunsin in Sphingomonas subterranea
Authors: Kodani Shinya , Hemmi Hikaru , Miyake Yuto , Kaweewan Issara , Nakagawa Hiroyuki 
Published: September 2018

Abstract
A shuttle vector pHSG396Sp was constructed to perform gene expression using Sphingomonas subterranea as a host. A new lasso peptide biosynthetic gene cluster, derived from Brevundimonas diminuta, was amplified by PCR and integrated to afford a expression vector pHSG396Sp-12697L. The new lasso peptide brevunsin was successfully produced by S. subterranea, harboring the expression vector, with a high production yield (10.2 mg from 1 L culture). The chemical structure of brevunsin was established by NMR and MS/MS experiments. Based on the information obtained from the NOE experiment, the three-dimensional structure of brevunsin was determined, which indicated that brevunsin possessed a typical lasso structure. This expression vector system provides a new heterologous production method for unexplored lasso peptides that are encoded by bacterial genomes.
Parental Investments in College and Later Cash Transfers
Authors: Haider Steven J. , McGarry Kathleen 
Published: September 2018

Abstract
Parents often provide generous financial transfers to their adult children, perhaps assisting with college expenses, recognizing major life course events, or cushioning against negative financial shocks. Because resources are limited, a transfer made to one child likely affects transfers made to others in the family. Despite such possibilities, data limitations have led previous authors to focus almost exclusively on a single type of transfer made at a single point in time. Using data from the Health and Retirement Study, we examine the relationships among parental transfers for college and later cash transfers to all children within a family. We find that parents typically spend differentially on the postsecondary schooling of their children but find no evidence that this differential spending is offset by later cash transfers.
Monic representations of finite higher-rank graphs
Authors: FARSI CARLA , GILLASPY ELIZABETH , JORGENSEN PALLE , KANG SOORAN , PACKER JUDITH 
Published: September 2018

In this paper, we define the notion of monic representation for the$C^{\ast }$-algebras of finite higher-rank graphs with no sources, and we undertake a comprehensive study of them. Monic representations are the representations that, when restricted to the commutative$C^{\ast }$-algebra of the continuous functions on the infinite path space, admit a cyclic vector. We link monic representations to the$\unicode[STIX]{x1D6EC}$-semibranching representations previously studied by Farsi, Gillaspy, Kang and Packer (Separable representations, KMS states, and wavelets for higher-rank graphs.J. Math. Anal. Appl. 434 (2015), 241–270) and also provide a universal representation model for non-negative monic representations.
Urogenital schistosomiasis and hybridization between Schistosoma haematobium and Schistosoma bovis in adults living in Richard-Toll, Senegal
Authors: Sene-Wade Mariama , Marchand Bernard , Rollinson David , Webster Bonnie L. 
Published: September 2018

AbstractSince the construction of the Diama Dam (1985), the epidemiology of schistosomiasis along the Senegal River Basin (SRB) has been extremely dynamic with outbreaks of both intestinal and urogenital schistosomiasis. In the early 2000s, technicians reported cases of suspected urogenital schistosomiasis in adults from the local hospital in Richard-Toll, Lower SRB. The genetic analysis of schistosome miracidia isolated from 11 patients in 2012 from two neighbourhoods (Campement and Gaya) of Richard-Toll confirmed infection with Schistosoma haematobium but also S. haematobium/S. bovis hybrids. Thirty-seven per cent of the miracidia were S. bovis/S. haematobium hybrids and 63% were pure S. haematobium. The data are discussed in relation to the ongoing dynamic epidemiology of the schistosomes in Senegal and the need to treat non-target individuals.
MULTIDISCIPLINARITY AND REFERENCE AS A SOLUTION TO INWARD-FOCUSED APPROACHES IN MUSIC COMPOSITION
Authors: Llach Federico 
Published: September 2018

AbstractNew Music thought and compositional praxis has excessively focused inward as a source of inspiration. In the last ten years, multidisciplinary composition has offered one possible solution to this problem. By combining music with theatrical elements and digital media, composers have produced works that are ‘not for the ears alone’. This paper offers a typification of its most novel aspects, and traces them in the author's own creative work, which additionally include the use of borrowed material as a means for establishing referentiality and elaborating semantic narratives.
Training for awareness of one's own spirituality: A key factor in overcoming barriers to the provision of spiritual care to advanced cancer patients by doctors and nurses
Authors: Bar-Sela Gil , Schultz Michael J. , Elshamy Karima , Rassouli Maryam , Ben-Arye Eran , Doumit Myrna , Gafer Nahla , Albashayreh Alaa , Ghrayeb Ibtisam , Turker Ibrahim , Ozalp Gulcin , Kav Sultan , Fahmi Rasha , Nestoros Sophia , Ghali Hasanein , Mula-Hussain Layth , Shazar Ilana , Obeidat Rana , Punjwani Rehana , Khleif Mohamad , Can Gulbeyaz , Tuncel Gonca , Charalambous Haris , Faraj Safa , Keoppi Neophyta , Al-Jadiry Mazin , Postovsky Sergey , Al-Omari Ma'an , Razzaq Samaher , Ayyash Hani , Khader Khaled , Kebudi Rejin , Omran Suha , Rasheed Osaid , Qadire Mohammed , Ozet Ahmet , Silbermann Michael 
Published: September 2018

AbstractObjectiveWhen patients feel spiritually supported by staff, we find increased use of hospice and reduced use of aggressive treatments at end of life, yet substantial barriers to staff spiritual care provision still exist. We aimed to study these barriers in a new cultural context and analyzed a new subgroup with “unrealized potential” for improved spiritual care provision: those who are positively inclined toward spiritual care yet do not themselves provide it.MethodWe distributed the Religion and Spirituality in Cancer Care Study via the Middle East Cancer Consortium to physicians and nurses caring for advanced cancer patients. Survey items included how often spiritual care should be provided, how often respondents themselves provide it, and perceived barriers to spiritual care provision.ResultWe had 770 respondents (40% physicians, 60% nurses) from 14 Middle Eastern countries. The results showed that 82% of respondents think staff should provide spiritual care at least occasionally, but 44% provide spiritual care less often than they think they should. In multivariable analysis of respondents who valued spiritual care yet did not themselves provide it to their most recent patients, predictors included low personal sense of being spiritual (p&lt; 0.001) and not having received training (p= 0.02; only 22% received training). How “developed” a country is negatively predicted spiritual care provision (p&lt; 0.001). Self-perceived barriers were quite similar across cultures.Significance of resultsDespite relatively high levels of spiritual care provision, we see a gap between desirability and actual provision. Seeing oneself as not spiritual or only slightly spiritual is a key factor demonstrably associated with not providing spiritual care. Efforts to increase spiritual care provision should target those in favor of spiritual care provision, promoting training that helps participants consider their own spirituality and the role that it plays in their personal and professional lives.
Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion
Authors: Nguyen Doan C. , Garimalla Swetha , Xiao Haopeng , Kyu Shuya , Albizua Igor , Galipeau Jacques , Chiang Kuang-Yueh , Waller Edmund K. , Wu Ronghu , Gibson Greg , Roberson James , Lund Frances E. , Randall Troy D. , Sanz Iñaki , Lee F. Eun-Hyung 
Published: September 2018

AbstractHuman antibody-secreting cells (ASC) in peripheral blood are found after vaccination or infection but rapidly apoptose unless they migrate to the bone marrow (BM). Yet, elements of the BM microenvironment required to sustain long-lived plasma cells (LLPC) remain elusive. Here, we identify BM factors that maintain human ASC > 50 days in vitro. The critical components of the cell-free in vitro BM mimic consist of products from primary BM mesenchymal stromal cells (MSC), a proliferation-inducing ligand (APRIL), and hypoxic conditions. Comparative analysis of protein–protein interactions between BM-MSC proteomics with differential RNA transcriptomics of blood ASC and BM LLPC identify two major survival factors, fibronectin and YWHAZ. The MSC secretome proteins and hypoxic conditions play a role in LLPC survival utilizing mechanisms that downregulate mTORC1 signaling and upregulate hypoxia signatures. In summary, we identify elements of the BM survival niche critical for maturation of blood ASC to BM LLPC.
Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes
Authors: Stevens Brett M. , Khan Nabilah , D’Alessandro Angelo , Nemkov Travis , Winters Amanda , Jones Courtney L. , Zhang Wei , Pollyea Daniel A. , Jordan Craig T. 
Published: September 2018

AbstractMyelodysplastic syndrome (MDS) is a chronic hematologic disorder that frequently evolves to more aggressive stages and in some cases leads to acute myeloid leukemia (AML). MDS arises from mutations in hematopoietic stem cells (HSCs). Thus, to define optimal therapies, it is essential to understand molecular events driving HSC pathogenesis. In this study, we report that during evolution of MDS, malignant HSCs activate distinct cellular programs that render such cells susceptible to therapeutic intervention. Specifically, metabolic analyses of the MDS stem cell compartment show a profound activation of protein synthesis machinery and increased oxidative phosphorylation. Pharmacological targeting of protein synthesis and oxidative phosphorylation demonstrated potent and selective eradication of MDS stem cells in primary human patient specimens. Taken together, our findings indicate that MDS stem cells are reliant on specific metabolic events and that such properties can be targeted prior to the onset of clinically significant AML, during antecedent MDS.
Fault-tolerant quantum computation with few qubits
Authors: Chao Rui , Reichardt Ben W. 
Published: September 2018

AbstractReliable qubits are difficult to engineer, but standard fault-tolerance schemes use seven or more physical qubits to encode each logical qubit, with still more qubits required for error correction. The large overhead makes it hard to experiment with fault-tolerance schemes with multiple encoded qubits. Here, we study the 15-qubit Hamming code, which protects seven encoded qubits to distance three. We give fault-tolerant procedures for applying arbitrary Clifford operations on these encoded qubits, using only two extra qubits, 17 in total. In particular, individual encoded qubits within the code block can be targeted. Fault-tolerant universal computation is possible with four extra qubits, 19 in total. The procedures could enable testing more sophisticated protected circuits in small-scale quantum devices. Our main technique is to use gadgets to protect gates against correlated faults. We also take advantage of special code symmetries, and use pieceable fault tolerance.
Intra-auditory integration between pitch and loudness in humans: Evidence of super-optimal integration at moderate uncertainty in auditory signals
Authors: Koh Kyung , Kwon Hyun Joon , Kiemel Tim , Miller Ross H. , Park Yang Sun , Kim Min Joo , Kwon Young Ha , Kim Yoon Hyuk , Shim Jae Kun 
Published: September 2018

AbstractWhen a person plays a musical instrument, sound is produced and the integrated frequency and intensity produced are perceived aurally. The central nervous system (CNS) receives defective afferent signals from auditory systems and delivers imperfect efferent signals to the motor system due to the noise in both systems. However, it is still little known about auditory-motor interactions for successful performance. Here, we investigated auditory-motor interactions as multi-sensory input and multi-motor output system. Subjects performed a constant force production task using four fingers in three different auditory feedback conditions, where either the frequency (F), intensity (I), or both frequency and intensity (FI) of an auditory tone changed with sum of finger forces. Four levels of uncertainty (high, moderate-high, moderate-low, and low) were conditioned by manipulating the feedback gain of the produced force. We observed performance enhancement under the FI condition compared to either F or I alone at moderate-high uncertainty. Interestingly, the performance enhancement was greater than the prediction of the Bayesian model, suggesting super-optimality. We also observed deteriorated synergistic multi-finger interactions as the level of uncertainty increased, suggesting that the CNS responded to increased uncertainty by changing control strategy of multi-finger actions.
Experimental verification of agglomeration effects in infrared spectra on micron-sized particles
Authors: Tamanai Akemi , Vogt Jochen , Huck Christian , Mick Uwe , Zimmermann Sören , Tazaki Ryo , Mutschke Harald , Pucci Annemarie 
Published: September 2018

Context. Detailed analysis of observed infrared (IR) dust emission spectra is often performed in order to derive information about mineralogy, particle size, and temperature of the dust. However, the IR bands are also influenced by agglomeration of the dust particles. Light scattering theory simulating agglomeration and growth effects is especially challenged by the consideration of highly absorbing particles.
Aims. To clarify the influence of agglomeration on the diagnostic phonon bands of amorphous SiO2 particles, we experimentally measure the extinction spectra of systematically arranged particle configurations and compare the measured spectra with the spectra obtained from different theoretical approaches.
Methods. We construct artificial particle agglomerates by means of the dedicated robotic manipulation (DRM) technique. IR microspectroscopic extinction measurements of these arranged particles are performed at the French National Synchrotron Facility, SOLEIL, in the mid-IR region considering polarization effects. The theoretical approaches applied are the discrete dipole approximation (DDA) as well as T-matrix and finite-difference time-domain methods.
Results. In both the experimental spectra and the theoretical calculations, we find that the Si–O stretching vibration band at about 9 μm is clearly broadened on the long-wavelength side by the agglomeration of particles. This is mainly caused by the radiation components, which are polarized in directions in which the agglomerate is extended, while the extinction band profile of the component polarized perpendicular to the long axis of an elongated agglomerate is close to the spectrum of the single sphere. All of the theoretical simulations predict these effects in qualitatively good agreement.
Conclusions. Our comparative study of the experimentally measured and theoretically calculated IR extinction spectra of well-defined agglomerate structures makes obvious how the various particle arrangements in small clusters might contribute to average spectra of dust. Therefore the study might help to improve the precision of light scattering calculations as well as their specific applicability.
Spatially resolving the thermally inhomogeneous outer atmosphere of the red giant Arcturus in the 2.3 μm CO lines
Authors: Ohnaka K. , Morales Marín C. A. L. 
Published: September 2018

Aim. The outer atmosphere of K giants shows thermally inhomogeneous structures consisting of the hot chromospheric gas and the cool molecular gas. We present spectro-interferometric observations of the multicomponent outer atmosphere of the well-studied K1.5 giant Arcturus (α Boo) in the CO first overtone lines near 2.3 μm.
Methods. We observed Arcturus with the AMBER instrument at the Very Large Telescope Interferometer (VLTI) at 2.28–2.31 μm with a spectral resolution of 12 000 and at projected baselines of 7.3, 14.6, and 21.8 m.
Results. The high spectral resolution of the VLTI/AMBER instrument allowed us to spatially resolve Arcturus in the individual CO lines. Comparison of the observed interferometric data with the MARCS photospheric model shows that the star appears to be significantly larger than predicted by the model. It indicates the presence of an extended component that is not accounted for by the current photospheric models for this well-studied star. We found out that the observed AMBER data can be explained by a model with two additional CO layers above the photosphere. The inner CO layer is located just above the photosphere, at 1.04 ± 0.02 R⋆, with a temperature of 1600 ± 400 K and a CO column density of 1020 ± 0.3 cm−2. On the other hand, the outer CO layer is found to be as extended as to 2.6 ± 0.2 R⋆ with a temperature of 1800 ± 100 K and a CO column density of 1019 ± 0.15 cm−2.
Conclusions. The properties of the inner CO layer are in broad agreement with those previously inferred from the spatially unresolved spectroscopic analyses. However, our AMBER observations have revealed that the quasi-static cool molecular component extends out to 2–3 R⋆, within which region the chromospheric wind steeply accelerates.
Tuck Jump Assessment as an Indicator for Upper Extremity Injury
Authors: Barfield Jeff , Oliver Gretchen 
Published: September 2018

AbstractThe purpose of this study was to determine if tuck jumps can be used as a dynamic movement assessment to ascertain a previous history of upper extremity injury in an overhead throwing sport. Seventy-one youth baseball and softball athletes (28 baseball/43 softball; 12.41±2.22 yrs.; 161.98±13.65 cm; 59.17 ± 14.90 kg) were recruited to participate and were placed in either the previous injury (N=18) or no previous injury (N=53) groups. Kinematic data were collected from jumps 4 through 8 during a trial of 10 tuck jumps performed at 100 Hz using an electromagnetic tracking system (trakSTARTM, Ascension Technologies, Inc., Burlington, VT, USA) synced with the MotionMonitor® (Innovative Sports Training, Chicago, IL, USA). A logistic regression showed no significance in trunk flexion or upper leg elevation in the ability to determine upper extremity injury (χ

2
(1, N=71)=3.55, p=0.315). In conclusion, examining only trunk flexion and upper leg elevation during the tuck jump assessment (TJA) is not enough for clinicians to recognize previous upper extremity injury. Even though the body behaves as a kinetic chain, simplifying the dynamic movement assessment while not specifying the type of upper extremity injury is not favorable for the clinician to identify previous injury.
Magnetic Resonance Imaging-Based Prevalence of Anterolateral Ligament Abnormalities and Associated Injuries in Knees with Acute Anterior Cruciate Ligament Injury
Authors: Song Yoonah , Yang Jae-Hyuk , Choi Won Rak , Lee Jin Kyu 
Published: September 2018

AbstractThe purpose of this study was to determine and compare the prevalence of anterolateral ligament abnormality and associated injuries among patients with complete and partial anterior cruciate ligament tears. In addition, the prevalence of associated injuries with anterolateral ligament abnormality was further analyzed. Of the 158 patients diagnosed with acute anterior cruciate ligament tear, 82 patients were diagnosed with acute complete anterior cruciate ligament confirmed by magnetic resonance imaging (MRI) and arthroscopic procedures (Group C), and 74 patients were diagnosed with acute partial anterior cruciate ligament tears confirmed by MRI (Group P). The status of the anterolateral ligament, collateral ligaments, menisci, and osseous lesions was assessed. There was a significantly higher prevalence of anterolateral ligament abnormalities in Group C than Group P (36.6 vs. 4.1%, p < 0.001). Medial collateral ligament, lateral collateral ligament, Segond fracture, osseous lesion at the fibular head, lateral tibial plateau, lateral femoral condyle, and medial tibial plateau were significantly associated with anterolateral ligament abnormality. Furthermore, severity of osseous lesion at the lateral tibial plateau, lateral femoral condyle, and medial tibial plateau was significantly associated (with linear correlation) with anterolateral ligament abnormality. The prevalence of anterolateral ligament abnormality was significantly higher in patients with complete anterior cruciate ligament tear (36.6%) than those with partial anterior cruciate ligament tear (4.1%), but with noticeable prevalence of anterolateral ligament abnormality in the partial anterior cruciate ligament tear group. Associated lesions significant to anterolateral ligament abnormality were tears in both collateral ligaments, lateral-sided osseous lesions, and osseous lesion of the medial tibial plateau.