bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and psychometric assessment of a novel survey to measure care coordination from the specialist's perspective
Authors: Vimalananda Varsha G. , Fincke Benjamin Graeme , Qian Shirley , Waring Molly E. , Seibert Ryan G. , Meterko Mark 
Published: April 2019

ObjectiveTo develop an online survey of care coordination with primary care providers as experienced by medical specialists, evaluate its psychometric properties, and test its construct validity.Data SourcesPhysicians (N = 633) from 13 medical specialties across the Veterans Health Administration.Study DesignWe developed the survey based on prior work (literature review, specialist interviews) and by adapting existing measures and developing new items. Multitrait scaling analysis and confirmatory factor analysis were used to assess scale structure. We used multiple linear regression to examine the relationship of the final coordination scales to specialists’ overall experience of care coordination.Data CollectionNovember 2016‐December 2016.Principal FindingsResults suggest a 13‐item, four‐factor survey [Relationships (k = 4), Roles and Responsibilities (k = 4), Communication (k = 3), and Data Transfer (k = 2)] that measures the medical specialist experience of coordination with good internal consistency reliability, convergent validity, discriminant validity, and goodness of fit. Together, the four scales explained nearly 50 percent of the variance in specialists’ overall experience of care coordination.ConclusionsThe 13‐item Coordination of Specialty Care—Specialist Survey (CSC‐Specialist) is the first of its kind. It can be used alone or embedded in other surveys to measure four domains of care coordination as experienced by medical specialists.
Review article: Outcomes of patients who are not transported following ambulance attendance: A systematic review and meta‐analysis
Authors: Yeung Timothy , Shannon Brendan , Perillo Samuel , Nehme Ziad , Jennings Paul , Olaussen Alexander 
Published: April 2019

AbstractThe aim of this systematic review and meta‐analysis was to evaluate the outcomes of patients who are not transported to hospital following ambulance attendance. A database search was conducted using PubMed, Medline, Embase, CINAHL and Cochrane Library. Studies were included if they analysed the outcomes of patients who were not transported following ambulance attendance. The primary outcome of this review was subsequent presentation to an ED following a non‐transport decision. Secondary outcome measures included hospital admission, subsequent presentation to alternative service provider (e.g. private physician), and death at follow up. The search yielded 1953 non‐duplicate articles, of which 10 met the inclusion criteria. Three studies specified that the non‐transport decision was emergency medical services (EMS)‐initiated, seven studies did not specify. Meta‐analysis found substantial heterogeneity between estimates (I2 >50%) that was likely because of differences in study design, length of follow up, patient demographic and sample size. Between 5% and 46% (pooled estimate 21%; 95% CI 11–31%) of non‐transport patients subsequently presented to ED. Few (pooled estimate 8%; 95% CI 5–12%) EMS‐initiated non‐transport patients were admitted to hospital compared to the unspecified group (pooled estimate 40%; 95% CI 7–72%). Mortality rates were low across included studies. Studies found varying estimates for the proportion of patients discharged at the scene that subsequently presented to ED. Few patients were admitted to hospital when the non‐transport decision was initiated by EMS, indicating EMS triage is a relatively safe practice. More research is needed to elucidate the context of non‐transport decisions and improve access to alternative pathways.
Hemodialysis Product and Hip Fracture in Hemodialysis Patients: A Nationwide Cohort Study in Japan
Authors: Wakasugi Minako , Kazama Junichiro J , Kikuchi Kan , Yasuda Kaoru , Wada Atsushi , Hamano Takayuki , Masakane Ikuto , Narita Ichiei 
Published: April 2019

AbstractSome have raised concerns that longer and more frequent hemodialysis (HD) would be associated with bone fractures due to excess phosphate removal. We examined the effects of hemodialysis product (HDP) on hip fracture incidence among Japanese HD patients using registry data of the Japanese Society for Dialysis Therapy. During a 1‐year study period, 1411 hip fractures occurred among 135 984 patients. After adjusting for demographic and clinical factors, patients with a high HDP did not show a significant risk of hip fracture. Interestingly, patients with polycystic kidney disease had a lower risk of hip fracture. Our findings did not support the hypothesis that patients undergoing longer and more frequent HD would face a higher risk of hip fracture than those undergoing shorter and less frequent HD. Polycystic kidney disease was identified as a new significant factor for hip fracture; relative to glomerulonephritis, this condition was associated with a lower risk of hip fracture.
miR‐29c improves skeletal muscle mass and function throughout myocyte proliferation and differentiation and by repressing atrophy‐related genes
Authors: Silva William José , Graça Flavia Aparecida , Cruz André , Silvestre João Guilherme , Labeit Siegfried , Miyabara Elen Haruka , Yan Chao Yun Irene , Wang Da Zhi , Moriscot Anselmo Sigari 
Published: April 2019

AbstractAimTo identify microRNAs (miRs) involved in the regulation of skeletal muscle mass. For that purpose, we have initially utilized an in silico analysis, resulting in the identification of miR‐29c as a positive regulator of muscle mass.MethodsmiR‐29c was electrotransferred to the tibialis anterior to address its morphometric and functional properties and to determine the level of satellite cell proliferation and differentiation. qPCR was used to investigate the effect of miR‐29c overexpression on trophicity‐related genes. C2C12 cells were used to determine the impact of miR‐29c on myogenesis and a luciferase reporter assay was used to evaluate the ability of miR‐29c to bind to the MuRF1 3′UTR.ResultsThe overexpression of miR‐29c in the tibialis anterior increased muscle mass by 40%, with a corresponding increase in fibre cross‐sectional area and force and a 30% increase in length. In addition, satellite cell proliferation and differentiation were increased. In C2C12 cells, miR‐29c oligonucleotides caused increased levels of differentiation, as evidenced by an increase in eMHC immunostaining and the myotube fusion index. Accordingly, the mRNA levels of myogenic markers were also increased. Mechanistically, the overexpression of miR‐29c inhibited the expression of the muscle atrophic factors MuRF1, Atrogin‐1 and HDAC4. For the key atrogene MuRF1, we found that miR‐29c can bind to its 3′UTR to mediate repression.ConclusionsThe results herein suggest that miR‐29c can improve skeletal muscle size and function by stimulating satellite cell proliferation and repressing atrophy‐related genes. Taken together, our results indicate that miR‐29c might be useful as a future therapeutic device in diseases involving decreased skeletal muscle mass.
Evaluation of the impact of cachexia on clinical outcomes in aggressive lymphoma
Authors: Burkart Madelyn , Schieber Michael , Basu Sanjib , Shah Palmi , Venugopal Parameswaran , Borgia Jeffrey A. , Gordon Leo , Karmali Reem 
Published: April 2019

SummaryCancer cachexia is a state of involuntary weight loss and altered body composition triggered by an underlying malignancy. We sought to correlate measures of cachexia with clinical outcomes in aggressive lymphomas and to identify biological pathways involved in the cachexia phenotype for possible druggable targets. Radiographic measures of cachexia were collected in a retrospective cohort of 109 patients with aggressive B‐cell lymphoma and followed for clinical outcome. We found males with sarcopenia had reduced progression‐free survival (5·4 vs. 72·3 months, P < 0·0005) and overall survival (OS; 30·2 months vs. not reached, NR, P = 0·02); males with adipopenia also had decreased OS (21·6 months vs. NR, P = 0·04). A trend for increased OS was observed in female sarcopenics only (32·8 months vs. NR, P = 0·08). Additionally, we analysed a prospective cohort of 14 patients for differences in circulating molecular targets involved in various biological pathways. There was a significant correlation with cachexia for reduced serum levels of mediators within the glucose utilization [insulin ‐like growth factor (IGF)‐binding protein 6, P = 0·04; IGF‐1, P = 0·02], inflammation (lymphotoxin‐like inducible protein that competes with glycoprotein D for herpesvirus entry on T cells; LIGHT, P = 0·005), and energy intake/expenditure (leptin, P = 0·004). We conclude that cachexia in patients with aggressive lymphomas has sex‐specific prognostic utility and correlates with measurable changes in metabolism and immune function.
Television exposure, consumer culture values, and lower well‐being among preadolescent children: The mediating role of consumer‐focused coping strategies
Authors: Dunkeld Charlotte , Wright Mark L. , Banerjee Robin A. , Easterbrook Matthew J. , Slade Lance 
Published: April 2019

Previous research has linked materialism to lower well‐being in children, and recent findings suggest that this link is heightened among those exposed to high levels of advertising. One proposal is that children may be pursuing consumer culture ideals (CCIs) – orienting to material possessions and physical appearance – as a maladaptive coping strategy for dealing with underlying distress. The present work offers the first direct evaluation of this theoretically plausible hypothesis. In Study 1, higher scores on our measure of consumer‐focused coping (CFC) not only predicted lower well‐being in a sample of 109 9‐ to 11‐year‐olds, but also served as mediator in the indirect link between the number of hours spent watching television and lower well‐being. Study 2 tested our expanded model of these processes in a sample of 380 9‐ to 11‐year‐olds. Specifically, structural equation modelling revealed that frequency of watching commercial (advertising‐rich) television in particular predicted greaterCFC. This, in turn, predicted greater endorsement ofCCIs, which then predicted lower well‐being. Implications for theoretical models and educational interventions are discussed.
LncRNA TPT1‐AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression
Authors: Wu Weimin , Gao Hao , Li Xiaofeng , Zhu Yong , Peng Shumin , Yu Jing , Zhan Guangxi , Wang Jiapo , Liu Na , Guo Xiaoqing 
Published: April 2019

AbstractIncreasing numbers of studies have confirmed that long noncoding RNA (lncRNA) play a critical role in epithelial ovarian cancer (EOC) progression. However, the potential function of the lncRNA tumor protein translationally controlled 1 (TPT1) antisense RNA 1 (TPT1‐AS1) in EOC is unclear. In this study, we aimed to uncover the biological roles and regulatory mechanisms of TPT1‐AS1 in EOC progression and metastasis. First, TPT1‐AS1 expression was significantly higher in EOC metastatic tissue and cell lines than in their respective control counterparts. In addition, ectopic TPT1‐AS1 expression was strongly associated with unfavorable EOC clinicopathological features, including FIGO stage, tumor size and tumor differentiation. TPT1‐AS1 overexpression remarkably induced cell proliferation, migration and invasion, and significantly attenuated cell adhesion ability in vitro and facilitated nude mouse subcutaneous xenograft growth and intraperitoneal metastasis in vivo, while the downregulation of TPT1‐AS1 expression produced the opposite effect in vitro. Mechanistically, TPT1‐AS1 was proven to be primarily distributed in EOC cell nuclei and positively modulated TPT1 promoter activity and transcription. Moreover, the oncogenic effects of TPT1‐AS1 could be reversed by TPT1 depletion, and the PI3K/AKT signaling pathway downstream of TPT1 was also altered. These results suggested that TPT1‐AS1 induced EOC tumor growth and metastasis through TPT1 and downstream PI3K/AKT signaling and that TPT1‐AS1 may be a promising therapeutic target for EOC.
Segregated from the City: Women’s Spaces in Islamic Movements in Pakistan
Authors: Zaman Meryem F. 
Published: April 2019

AbstractWomen’s spaces in Islamic movements in Pakistan appear very similar in their external elements but are radically different in their reorganizations of domestic space, which signal deliberate attempts by movement leaders to appease urban middle‐ and upper‐class Pakistani anxieties related to the demands these movements make on women’s time and attention. Leaders lay out guidelines for the creation of space which attempt to speak to multiple audiences regarding women’s roles in these movements.I draw on the work of Michel de Certeau to examine the ways in which female members alter the carefully structured spaces of Islamic movements by living in them, and significantly shape women’s movement‐defined roles. I argue that women ultimately combine movement leaders’ visions with their own understandings of virtuous practice to enunciate new ways of imagining their role within movements and in urban Pakistan. [Pakistan; Islamabad; Islamic Movements; Space; Gender]
Diagnosis of urinary bladder urothelial carcinoma by immunocytology with p53, MCM5, MCM2 and Ki‐67 antibodies using cell blocks derived from urine
Authors: Brisuda Antonín , Háček Jaromír , Čechová Marcela , Škapa Petr , Babjuk Marek 
Published: April 2019

AbstractObjectiveImmunocytochemistry has attained a marginal role in urology so far. Combining the morphological and immunophenotypical changes of the urothelial cells retrieved from urine is a logical approach. The study aimed to analyse the diagnostic potential of immunocytological staining in the detection of high‐grade and low‐grade urothelial carcinoma.MethodsFreshly voided urine was collected from 152 consecutive individuals, cytology classes were determined and cell blocks produced. A total of 77 patients were diagnosed with urothelial carcinoma and 75 patients had various benign urological conditions. Immunocytochemistry was performed using four antibodies: p53, MCM2, MCM5 and Ki‐67. A diagnostic power to detect low grade and high‐grade urothelial carcinoma was analysed for each antibody and their combinations with cytology.ResultsThere were no significant differences between patients with low‐grade tumours and control group. Antibodies p53 and Ki‐67 slightly improved the sensitivity of urinary cytology while maintaining its specificity. The best negative predictive value was demonstrated in combinations of cytology and MCM5 (88.9%) and cytology, p53 and MCM5 (90.6%). In the diagnosis of high‐grade tumours, all antibodies apart from MCM2 yielded better sensitivity and specificity than cytology alone (receiver operating characteristic curves: p53 = 0.853, MCM5 = 0.931, and Ki‐67 = 0.895). Combined with cytology, the sensitivities went even higher for the cost of lower specificity. The best diagnostic performance was observed in the combination of MCM5 and Ki‐67 (sensitivity = 96.2%; specificity = 80%).ConclusionsImmunocytochemistry with p53, MCM5 and Ki‐67 antibodies can improve the diagnostic power of urinary cytology in the detection and follow‐up of urinary bladder urothelial carcinoma.
Alcohol use in family, domestic and other violence: Findings from a cross‐sectional survey of the Australian population
Authors: Curtis Ashlee , Vandenberg Brian , Mayshak Richelle , Coomber Kerri , Hyder Shannon , Walker Arlene , Liknaitzky Paul , Miller Peter G. 
Published: April 2019

AbstractIntroduction and AimsThe link between alcohol and experience of violence is well‐documented, but there is a paucity of empirical research on the role of alcohol specifically in family and domestic violence (FDV) in Australia. The aim of the current study was to describe the relationship between alcohol use and FDV in the Australian population, and to examine key differences between three different types of violence: family violence, intimate partner violence (IPV) and other violence.Design and MethodsAn online panel survey was conducted using a stratified random sampling design.ResultsIn total, 5118 respondents were included, of whom 44.5% reported experiencing violence in their lifetime, and 6.0% reported recent (past year) experience of violence. Recent violent incidents were comprised of IPV (41.8%), family violence (13.1%) and other violence (45.1%). Approximately one‐third of all violent incidents experienced (either as a victim or perpetrator) were alcohol‐related, and 37.8% of respondents who experienced IPV and 27.8% of those who experienced family violence reported past year heavy‐episodic drinking. Alcohol use was associated with higher rates of physical violence and injury at IPV incidents. Alcohol consumed at IPV incidents was most often purchased from a supermarket liquor store (37.0%) and consumed at the respondent's home, regardless of the distance between the purchase location and incident location.Discussions and ConclusionsThis study found that alcohol is frequently involved in FDV incidents, particularly IPV. Alcohol use was associated with a higher chance of physical violence and of injury at IPV incidents.
Analysis of the factors involved in procedural failure: Endoscopic retrograde cholangiopancreatography using a short‐type single‐balloon enteroscope for patients with surgically altered gastrointestinal anatomy
Authors: Tanisaka Yuki , Ryozawa Shomei , Mizuide Masafumi , Harada Maiko , Fujita Akashi , Ogawa Tomoya , Nonaka Kouichi , Tashima Tomoaki , Araki Ryuichiro 
Published: April 2019

AimTo analyze factors involved in procedural failure and to discuss responses to procedural failure by using the outcomes of endoscopic retrograde cholangiopancreatography (ERCP) carried out using a short‐type single‐balloon enteroscope (short SBE) in patients with surgically altered gastrointestinal anatomy.MethodsThe study sample included patients who underwent ERCP‐related procedures using a short SBE between September 2011 and September 2018 at our hospital. Outcomes, including procedural success rate, were studied retrospectively to analyze the factors involved in procedural failure.ResultsAnalysis included 191 procedures carried out in 121 patients. Procedural success rate was 85.9% with an adverse event rate of 8.4%. Causes of procedural failure included malignant biliary obstruction (odds ratio [OR] 2.89, 95% confidence interval [CI] 1.19–7.25, P = 0.02), first ERCP attempt (OR: 5.32, 95% CI: 1.30–36.30, P = 0.02), and Roux‐en‐Y reconstruction (OR: 0.08, 95% CI: 0.004–0.39, P < 0.001). With regard to the response to failure, in cases of malignant biliary obstruction, reattempted short SBE‐assisted ERCP was difficult because of invasion of the small intestine or papilla. A large number of these cases required alternative treatment (10 of 15 cases, 66.7%) using percutaneous transhepatic biliary drainage (PTBD) or endoscopic ultrasound‐guided biliary drainage (EUS‐BD).ConclusionEndoscopic retrograde cholangiopancreatography using a short SBE is safe and effective, with malignant biliary obstruction being a specific cause of failure. Technical proficiency with different modalities, such as PTBD and EUS‐BD, is necessary to respond to failure in these cases.
Improving the scientific rigour of nutritional recommendations for adults with type 2 diabetes: A comprehensive review of the American Diabetes Association guideline‐recommended eating patterns
Authors: Hallberg Sarah J. , Dockter Nancy E. , Kushner Jake A. , Athinarayanan Shaminie J. 
Published: April 2019

AbstractAimsThe global rate of type 2 diabetes (T2D) continues to rise. Guidelines that influence the worldwide treatment of this disease are central to changing this trajectory. We sought in this review to evaluate the appropriateness of sources cited in the American Diabetes Association's (ADA) guidelines on eating patterns for T2D management, identify additional relevant sources, and evaluate the evidence.Materials and MethodsWe reviewed the evidence behind the ADA's recommendations on eating patterns in the 2018 and 2019 ADA Standards of Care and the 2014 ADA Nutrition Therapy Recommendations for Adults with Diabetes. Additionally, we conducted a comprehensive search to identify any additional studies not included in the cited evidence. To determine appropriateness of inclusion in the guidelines, the following criteria were applied: 1) it was a clinical trial or systematic review/meta‐analysis of clinical trials; 2) it involved persons with T2D; 3) one of the study arms followed one of the eating patterns currently recommended; 4) its reported outcomes included glycaemic control; 5) outcomes were reported separately for persons with T2D.ResultsWe found a wide variation in the evidence for each eating pattern. Issues that have hampered the guideline process include: lack of a rigorous literature review, resulting in the omission of pertinent studies; an overreliance on prospective cohort studies; inconsistent standards for evidence; inclusion of studies not on persons with T2D; and bias.ConclusionsThe ADA Guidelines recommended eating patterns fall short of rigorous standards of scientific review according to state‐of‐the‐art systematic review and guideline creation practices.
Characteristics and outcomes of young adults with Philadelphia‐negative myeloproliferative neoplasms
Authors: Barzilai Merav , Kirgner Ilya , Avivi Irit , Ellis Martin , Dally Najib , Rozovski Uri , Lavi Noa 
Published: April 2019

AbstractObjectiveApproximately 10% of Philadelphia (Ph)‐negative myeloproliferative neoplasms (NPM) are diagnosed at young adulthood. We aim to define the features of this group.MethodsA multicenter retrospective study, including patients 18‐45 years of age, diagnosed with Ph‐negative MPN between 1985 and 2017.ResultsOne hundred nine patients were included, 37 with polycythemia vera (34%), 54 with essential thrombocytosis (50%), 15 with primary myelofibrosis (PMF) (14%), and 3 with MPN unclassifiable (3%). Median age was 33 years and 62 (57%) were females. During a median follow‐up of 8 years, 39 patients (37%) had at least one thrombotic event. 30/39 of events were venous (77%), 23/30 of which were splanchnic (77%). In 14/39 (36%), thrombosis preceded MPN diagnosis. In a multivariable analysis, only splenomegaly predicted for thrombosis (HR 5.6, CI: 1.4‐22). The 10‐year risk for secondary myelofibrosis was similar for ET and PV (0.13 vs 0.19, P = 0.51). The 10‐year risk for leukemic transformation or mortality was significantly higher for PMF (0.3, P = 0.04).ConclusionsThe risks of mortality and of progression to MF/leukemia in young adults are similar to older population. Thrombotic events are frequently a presenting sign with a high incidence of venous, in particular splanchnic, events.