bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrieving Global Wilson Currents from Electrified Clouds Using Satellite Passive Microwave Observations
Authors: Peterson Michael , Deierling Wiebke , Liu Chuntao , Mach Douglas , Kalb Christina 
Published: May 2018

AbstractHigh-altitude atmospheric electricity measurements have been used to calculate the conduction (Wilson) currents that are supplied to the global electric circuit (GEC) by individual electrified clouds. Quantifying the global average current and assessing its temporal variability is a challenge, however, because it requires measurements in every stormy region of the world. Thus, a retrieval algorithm has been developed to infer the electric fields and Wilson currents above electrified weather from NASA ER-2 passive microwave high-altitude aircraft observations that are also common satellite products.This study documents the adaptation of the passive microwave electric field and the Wilson current retrieval algorithm for use with satellite platforms. Three distinct variants on the algorithm are produced to respond to specific use cases that differ in 1) whether swath or microwave feature data are available to describe the lateral extent of electrified clouds, 2) the availability of coincident radar data to characterize the vertical structure of electrified clouds, and 3) the prioritization of scientific accuracy or computational expense and product latency. The Wilson currents produced by the satellite retrievals are compared with each other and also with coincident lightning measurements and the Carnegie curve. The advantages, caveats, and limitations of each variant are discussed.
Knowledge Spillovers and Local Industry Growth: A Patent Citation Approach
Authors: Song Kejun , Simons Gerald , Sun Wei 
Published: May 2018

We create unique patent-based measures of Marshall–Arrow–Romer (MAR) and Jacobs knowledge spillovers using patent citations data and use them to test the Glaeser et al. model of local industry employment growth on three emerging technology categories, namely, computing and communications, drugs and medical, and electrics and electronics. We test growth in 45 U.S. metropolitan statistical areas (MSAs) and consolidated metropolitan statistical areas (CMSAs) for eight two-digit industries over the period 1994 to 2000. We find strong evidence for MAR spillovers from specialization, but little for Jacobs spillovers from diversity. Our results suggest that regional specialization, but not diversity, boosts local industry employment growth in these knowledge fields. JEL classifications: J21, L16
Statin use is not associated with an increased risk of acute pancreatitis—A meta‐analysis of observational studies
Authors: Poropat Goran , Archibugi Livia , Korpela Taija , Cárdenas-Jaén Karina , de Madaria Enrique , Capurso Gabriele 
Published: May 2018

BackgroundStatins are perceived as potential etiological factors for acute pancreatitis (AP), but recent evidence suggests the opposite. Our aim was to evaluate the association between statin use and risk of AP in observational studies.MethodsMedline, Scopus, and Web of Science were searched for cohort (C) and case‐control (CC) studies evaluating statins as intervention and AP as outcome. Pooled adjusted odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated.ResultsThirteen studies (seven CC, six C) with 34,899 AP patients and 5,377,894 controls were included. Prevalence of statin use was 9.8% among AP patients and 25% among controls. Pooled adjusted OR was 1.00 (95% CI = 0.63 to 1.59) with considerable heterogeneity (I2 = 98%). CC studies were associated with increased AP risk (OR = 1.33; 95% CI = 1.20 to 1.47), unlike C studies (OR = 0.69; 95% CI = 0.37 to 1.31). No association with increased risk was found for studies from Western countries (OR = 0.90; 95% CI = 0.52 to 1.56), unlike for studies conducted in Asia (OR = 1.39; 95% CI = 1.10 to 1.75).ConclusionStatin use is not associated with increased risk of AP. Increased risk was limited to CC studies, which are more prone to bias, while C studies showed no global effect. Further research is needed to clarify whether statin type, dosage, treatment duration or AP etiology might account for this difference.
In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL
Authors: Fiedler Eleanor R. C. , Bhutkar Arjun , Lawler Emily , Besada Rana , Hemann Michael T. 
Published: May 2018

Key Points
Functional in vivo screening reveals distinct genetic dependencies in a mouse model of BCR-ABL1+ BCP-ALL after dasatinib treatment. Disruption of the PAF/PAFR/PAFAH1B axis sensitizes leukemia cells to TKIs; this pathway may be a novel target for combination therapy.
The right place? Users and professionals’ constructions of the place’s influence on personal recovery in community mental health services
Authors: Femdal Ingrid 
Published: May 2018

Abstract
Background
Current mental health policy emphasizes the importance of community-based service delivery for people with mental health problems to encompass personal recovery. The aim of this study is to explore how users and professionals construct the place’s influence on personal recovery in community mental health services.

Methods
This is a qualitative, interpretive study based on ten individual, semi-structured interviews with users and professionals, respectively. A discourse analysis inspired by the work of Foucault was used to analyze the interviews.

Results
The findings show how place can be constructed as a potential for and as a barrier against recovery. Constructions of the aim of the services matter when choosing a place for the services. Further, constructions of user–professional relationships and flexibility are important in the constructions of an appropriate place for the services.

Conclusions
The aim of the service, the user–professional relationship, and flexibility in choosing place were essential in the participants’ constructions. To find “the right place” for mental health services was constructed as context-sensitive and complex processes of assessment and co-determination.
Trial registration The study is approved by the Regional Committee for Medical Research Ethics, Norway (REK-Midt 2011/2057)
A protocol for a randomised controlled trial of prefabricated versus customised foot orthoses for people with rheumatoid arthritis: the FOCOS RA trial [Foot Orthoses – Customised v Off‐the‐Shelf in Rheumatoid Arthritis]
Authors: Gallagher Kellie S. , Godwin Jon , Hendry Gordon J. , Steultjens Martijn , Woodburn Jim 
Published: May 2018

AbstractBackgroundFoot pain is common in rheumatoid arthritis and appears to persist despite modern day medical management. Several clinical practice guidelines currently recommend the use of foot orthoses for the treatment of foot pain in people with rheumatoid arthritis. However, an evidence gap currently exists concerning the comparative clinical‐ and cost‐effectiveness of prefabricated and customised foot orthoses in people with early rheumatoid arthritis. Early intervention with orthotics may offer the best opportunity for positive therapeutic outcomes. The primary aim of this study is to evaluate the comparative clinical‐ and cost‐effectiveness of prefabricated versus customised orthoses for reducing foot pain over 12 months.Methods/designThis is a multi‐centre two‐arm parallel randomised controlled trial comparing prefabricated versus customised orthoses in participants with early rheumatoid arthritis (< 2 years disease duration). A total of 160 (a minimum of 80 randomised to each arm) eligible participants will be recruited from United Kingdom National Health Service Rheumatology Outpatient Clinics. The primary outcome will be foot pain measured via the Foot Function Index pain subscale at 12 months. Secondary outcomes will include foot related impairments and disability via the Foot Impact Scale for rheumatoid arthritis, global functional status via the Stanford Health Assessment Questionnaire, foot disease activity via the Rheumatoid Arthritis Foot Disease Activity Index, and health‐related quality of life at baseline, 6 and 12 months. Process outcomes will include recruitment/retention rates, data completion rates, intervention adherence rates, and participant intervention and trial participation satisfaction. Cost‐utility and cost‐effectiveness analyses will be undertaken.DiscussionOutcome measures collected at baseline, 6 and 12 months will be used to evaluate the comparative clinical‐ and cost‐ effectiveness of customised versus prefabricated orthoses for this treatment of early rheumatoid arthritis foot conditions. This trial will help to guide orthotic prescription recommendations for the management of foot pain for people with early rheumatoid arthritis in future.Trial registrationISRCTN13654421. Registered 09 February 2016.
An enhanced sum rate in the cluster based cognitive radio relay network using the sequential approach for the future Internet of Things
Authors: Miah Md Sipon , Schukat Michael , Barrett Enda 
Published: May 2018

AbstractThe cognitive radio relay plays a vital role in cognitive radio networking (CRN), as it can improve the cognitive sum rate, extend the coverage, and improve the spectral efficiency. However, cognitive relay aided CRNs cannot obtain a maximal sum rate, when the existing sensing approach is applied to a CRN. In this paper, we present an enhanced sum rate in the cluster based cognitive radio relay network utilizing a reporting framework in the sequential approach. In this approach a secondary user (SU) extends its sensing time until right before the beginning of its reporting time slot by utilizing the reporting framework. Secondly all the individual measurement results from each relay aided SU are passed on to the corresponding cluster head (CH) through a noisy reporting channel, while the CH with a soft-fusion report is forwarded to the fusion center that provides the final decision using the n-out-of-k-rule. With such extended sensing intervals and amplified reporting, a better sensing performance can be obtained than with a conventional non-sequential approach, therefore making it applicable for the future Internet of Things. In addition, the sum rate of the primary network and CCRRN are also investigated for the utilization reporting framework in the sequential approach with a relay using the n-out-of-k rule. By simulation, we show that the proposed sequential approach with a relay (Lemma 2) provides a significant sum rate gain compared to the conventional non-sequential approach with no relay (Lemma 1) under any condition.
The missing link: toward an assessment of innovation capacity in health care organizations
Authors: Kievit Pieter J. , Oomes Jeanette , Schoorl Marianne , Bartels Piet 
Published: May 2018

AbstractThe health care sector shows a disjunction between the well-understood necessity for change and the capacity to realize it. Conventional management strategies and traditional means of influencing professionals often fail to deliver projected outcomes. We address this issue from a different angle. An organization’s capacity for change is determined by the combination of power distribution, value system and change readiness, which should be analyzed not as formal qualities but as aspects of the organization as a social system, disclosing a reality beneath the surface of mission statements, quality policy and management models. We describe a method to analyse the identity of an organization as a social system with respect to its innovation potential. This identity shows in the rules of discourse determining what is valid communication and which are the sources of impact of arguments in a communicative interaction leading to decisions. We present two case studies in which groups of physicians argue in favor of respectively against the availability of physician-assisted death (PAD) for terminal patients.
Ibrutinib as Treatment for Patients With Relapsed/Refractory Follicular Lymphoma: Results From the Open-Label, Multicenter, Phase II DAWN Study
Authors: Gopal Ajay K. , Schuster Stephen J. , Fowler Nathan H. , Trotman Judith , Hess Georg , Hou Jing-Zhou , Yacoub Abdulraheem , Lill Michael , Martin Peter , Vitolo Umberto , Spencer Andrew , Radford John , Jurczak Wojciech , Morton James , Caballero Dolores , Deshpande Sanjay , Gartenberg Gary J. , Wang Shean-Sheng , Damle Rajendra N. , Schaffer Michael , Balasubramanian Sriram , Vermeulen Jessica , Cheson Bruce D. , Salles Gilles 
Published: May 2018

Purpose The Bruton's tyrosine kinase inhibitor ibrutinib has demonstrated clinical activity in B-cell malignancies. The DAWN study assessed the efficacy and safety of single-agent ibrutinib in chemoimmunotherapy relapsed/refractory follicular lymphoma (FL) patients. Methods DAWN was an open-label, single-arm, phase II study of ibrutinib in patients with FL with two or more prior lines of therapy. Patients received ibrutinib 560 mg daily until progressive disease/unacceptable toxicity. The primary objective was independent review committee–assessed overall response rate (ORR; complete response plus partial response). Exploratory analyses of T-cell subsets in peripheral blood (baseline/cycle 3) and cytokines/chemokines (baseline/cycle 2) were performed for available samples. Results Between March 2013 and May 2016, 110 patients with a median of three prior lines of therapy were enrolled. At median follow-up of 27.7 months, ORR was 20.9% (95% CI, 13.7% to 29.7%, which did not meet the 18% lower-bound threshold for the primary end point). Twelve patients achieved a complete response (11%; 95% CI, 5.8% to 18.3%). Median duration of response was 19.4 months (range, 1 to ≥ 33 months), with a median progression-free survival of 4.6 months and a 30-month overall survival of 61% (95% CI, 0.51% to 0.70%). Lymphoma symptoms resolved in 67%. Seven of 32 patients who experienced initial radiologic progression responded upon continuing therapy (pseudoprogression). The most common adverse events were diarrhea, fatigue, cough, and muscle spasms; 48.2% of patients reported serious adverse events. In patients who experienced a response, regulatory T cells were downregulated at C3D1 ( P = .02), and Th1-promoting (antitumor) cytokines interferon-γ and interleukin-12 increased ( P ≤ .035). Conclusion With an ORR of 20.9%, ibrutinib failed to meet its primary efficacy end point in chemoimmunotherapy in patients with relapsed/refractory FL, although responses were durable and associated with a reduction in regulatory T cells and increases in proinflammatory cytokines.
Whole-body cryotherapy – promising add-on treatment of depressive disorders
Authors: Rymaszewska Joanna , Urbanska Katarzyna , Szcześniak Dorota , Pawłowski Tomasz , Pieniawska-Śmiech Karolina , Kokot Izabela , Pawlik-Sobecka Lilla , Płaczkowska Sylwia , Zabłocka Agnieszka , Stańczykiewicz Bartłomiej 
Published: May 2018

Cel pracyNadal istnieje zapotrzebowanie na nowe, efektywne biologiczne interwencje terapeutyczne w epizodach depresyjnych i zaburzeniu depresyjnym nawracającym. Krioterapia ogólnoustrojowa (WBC), będąca formą stymulacji ogólnoustrojowej temperaturami kriogenicznymi, jest coraz częściej stosowaną metodą leczniczą w schorzeniach neurologicznych oraz w reumatologii. Badanie miało na celu określenie skuteczności krioterapii ogólnoustrojowej jako augmentacji leczenia epizodu depresyjnego.MetodaDo badania obserwacyjnego zrekrutowano 30 dorosłych pacjentów leczonych ambulatoryjnie z powodu epizodu depresyjnego. 21 osób (17 kobiet, 81%) ze średnią wieku 46,1 (±16,7) lat ukończyło badanie. Do określenia nasilenia objawów depresyjnych u badanych użyto Skali Depresji Hamiltona oraz Inwentarza Depresji Becka. Jakość życia oceniano WHOQoL-Bref a poziom anhedonii skalą SHAPS. W okresie 2 tygodni przeprowadzono 10 dwuminutowych sesji ekspozycji na skrajnie niskie temperatury (od -110 do -135 stopni Celsjusza).WynikiPo cyklu kriostymulacji ogólnoustrojowej stwierdzono znaczącą poprawę w postaci redukcji ogólnej punktacji w skalach oceniających objawy depresyjne HDRS między T1 (16,94±4,3) i T4 (4,50±4,2) (p<0.00001) oraz BDI (T1: 13,48±4,6; T4: 6,14±6.7, p<0,03), nasilenie anhedonii w skali SHAPS (p=0,011), oraz wyższe wyniki w skali jakości życia w domenach: poczucie zdrowia fizycznego (p=0,024), poczucie zdrowia psychicznego (p=0,016) oraz w domenie środowiskowej (p=0,003). Zauważono istotny wzrost samodzielnie ocenianego samopoczucia przy użyciu skali VAS przed i po przebytych zabiegach (p<0,00001). Nie stwierdzono wpływu krioterapii ogólnoustrojowej na zmianę poziomu cytokin, NO, hsCRP, OB oraz TAS we krwi uczestników przed i po zakończeniu cyklu krioterapii (p>0,05).WnioskiKrioterapia ogólnoustrojowa okazała się efektywną, bezpieczną oraz dobrze tolerowaną dodatkową interwencją terapeutyczną wśród pacjentów z epizodem depresyjnym. Dalsze randomizowane badania z grupą kontrolną powinny zostać przeprowadzone.
Teaching Physical Examination to Medical Students on Inpatient Medicine Teams: A Prospective, Mixed‐Methods Descriptive Study
Authors: Bergl Paul A. , Taylor Allison C. , Klumb Jennifer , Quirk Kerrie , Muntz Martin D. , Fletcher Kathlyn E. 
Published: May 2018

Physical examination (PE) is a core clinical competency, and the internal medicine clerkship is a premiere venue for students to develop PE skills. However, clinical rotations often lack opportunities for real‐time instruction. We sought to measure the frequency, content, and factors affecting PE instruction during the internal medicine clerkship. We conducted a prospective mixed‐methods study at a single academic center. Data were gathered by a student researcher who directly observed inpatient teams over 3 months. We quantified the frequency of PE teaching activities and analyzed daily written observations using qualitative content analysis. PE was most frequently discussed during bedside rounds and least often during workroom rounds. Direct observation of students' examinations rarely occurred. Multiple factors in the learning environment were posited to affect PE instruction. In brief, we found that residents and attending physicians who are part of internal medicine teaching services do not routinely emphasize PE instruction.
Marshall McLuhan’s New Science as a case of reflection concerning common ground for art, science and technology
Authors: Knosala Bartłomiej , Kuzior Aleksandra 
Published: May 2018

Abstract
The main aim of this article is to present Marshall McLuhan’s Laws of Media in the context of the philosophies of Francis Bacon and Giambattista Vico. Understanding the interconnection between language, senses and cognition is crucial in philosophically joining the three new sciences: Bacon’s Novum Organum, Vico’s Scienzia Nuova and McLuhan’s New Science. At the same time, we point to the fact that such a theoretical basis allows us to understand art, science and technology not as distinct forms of human activity but as integrally linked ones. In this sense, McLuhan’s thought can inspire further studies, the object of which is to overcome the so-called problem of two cultures.
Why am I here? A self-study of an international art education student lost in transition
Authors: Yi Seonjeong 
Published: May 2018

Abstract
This article is an arts-based inquiry into the often overlooked stories of international graduate students (IGSs) in art education. In this case, I draw on my experiences as a Korean graduate student in Canada, rendered through visuals and text. As part of my ongoing reflective process, I approached this project through life writing and drawing as a means to articulate my understandings of the moments within my first year in the programme. The questions that guided my research include the following: What kind of academic adaptation issues do IGSs experience? Does a personal story provide useful insight into the phenomena of the academic adaptation process? And how do visual narratives as arts-based educational research (ABER) provide a rendering of the experience of an IGS? With this intent, this article examines diverse ways that help to broaden and deepen the discourses of international students in educational studies.
In the context of public pedagogy: Transit
Authors: Güneş Nurhayat 
Published: May 2018

Abstract
I came to Vancouver, Canada as a visiting Ph.D. student to study a/r/tography at the University of British Columbia (UBC). The multinational and multicultural nature of the city of Vancouver became an unexpected learning resource during my stay. I soon became consumed by my own everyday learning and in time, I began to understand the power of public pedagogy, or in other words, those informal learning opportunities outside institutional forms of learning. In this visual essay, I examine the concept of transit as one dimension of public pedagogy. This concept emerged from photographs and anecdotes taken during my everyday use of public transit. I used a/r/tography as a practice-based art education research methodology to guide my work. Transit became a bodied and embodied form of living inquiry as I investigated the very nature of public transit as public pedagogy.
Fabricating consent for an ‘adjustment programme’: Crisis narratives of economic journalists in Portugal
Authors: de Almeida João Ramos , Castro Caldas José , Costa Ana 
Published: May 2018

Abstract
Following Greece and Ireland, and preceding Spain and Cyprus, Portugal has been subject to a troika ‘adjustment programme’ that lasted from mid-2011 to mid-2014. The implementation of the programme was disturbed by unexpected events stemming from internal political tensions, ‘exogenous’ shocks, resistance from the judicial system (the Constitutional Court) and opposition from large sections of the public. As in Greece, the programme was experienced by most as a dramatic and traumatic event. Major actors in this drama have been the troika institutions, the Portuguese government and its supporting parties, the Portuguese opposition parties, trade unions and other social movements. Other actors, namely journalists, arguably also played an important role. This article examines the role played by economic journalists during the so-called adjustment process. It analyses the content of the publications (op-eds) of main Portuguese economic journalists prior to and during the period of implementation of the troika’s programme. It is based on a survey of all the publications (op-eds) of six authors between 1 January 2010 and 30 July 2014. The analysis of the journalists’ texts led to the following conclusions: (1) the texts are rooted in a particular set of core (neo-liberal) beliefs about the economy and its functioning, what we call the ‘consensus view’; (2) the crisis is perceived as an opportunity not to be missed to implement long due reforms aimed at a neo-liberal reshaping of the economy and society and (3) the texts were mainly concerned with deflecting opposition to, or fabricating consent in favour of, the troika’s ‘adjustment’.