bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preserving fertility in women with cancer (PreFer): Decision‐making and patient‐reported outcomes in women offered egg and embryo freezing prior to cancer treatment
Authors: Vogt Katharina S. , Hughes Jane , Wilkinson Anna , Mahmoodi Neda , Skull Jonathan , Wood Hilary , McDougall Sophia , Slade Pauline , Greenfield Diana M. , Pacey Allan , Ledger William , Jones Georgina L. 
Published: August 2018

AbstractObjectiveWomen of childbearing age with new cancer diagnoses have to make rapid decisions about fertility preservation (FP) before starting cancer treatment (CT). The aim of the PreFer study was to explore this FP decision‐making process and its impact on patient‐reported outcomes (PROMs) and health‐related quality of life (HRQoL).MethodsA prospective, mixed‐methods design was used (questionnaires, in‐depth interviews). Interviews were analysed using thematic analysis. Fifty‐eight women with new cancer diagnoses were recruited. Comparisons were made between women who declined FP referral in oncology (Group1) and women who chose referral (Group2). Group 2 was further split into those who had some FP (2A) and those who did not (2B). Questionnaires and PROMs were administered prior to and after the fertility consultation, before the start of CT and 3 months post CT. Interviews were conducted with one participant from Group 2.ResultsHRQoL was negatively affected, particularly depression. Women's lack of understanding about the relationship between CT and fertility were evident. Five themes emerged from the interviews as barriers and facilitators to the FP decision‐making process.ConclusionThe results indicate that better information and support resources aimed at women to support their decision making are needed, such as patient decision‐aids. Women from Group 1 were found to suffer significantly worse depression compared with the general UK population, highlighting the need for psychological support in the FP care‐pathway and for research exploring the contributions of depression and hopelessness to the decision‐making process.
Proteomic Analysis of Human Scleroderma Fibroblasts Response to Transforming Growth Factor‐ß
Authors: Chaigne Benjamin , Clary Guilhem , Le Gall Morgane , Dumoitier Nicolas , Fernandez Claire , Lofek Sebastien , Chafey Philippe , Moinzadeh Pia , Krieg Thomas , Denton Christopher P. , Mouthon Luc 
Published: August 2018

PurposeSystemic sclerosis (SSc) is characterized by autoimmunity, vasculopathy and fibrosis. Fibrosis is due to an activation of fibroblasts by the transforming growth factor‐ß (TGF‐ß). This study investigates the proteomic response of SSc fibroblasts to TGF‐ß.Experimental designSkin fibroblasts from diffuse SSc patients and healthy controls (HC) are cultured with or without TGF‐ß. Two‐dimensional differential in‐gel electrophoresis and mass spectrometry (MS) combined with Ingenuity Pathway analysis (IPA) and Panther/David software analyze proteins differentially expressed between groups. Real‐time cell analyzer (RTCA) assesses fibroblast proliferation and viability.ResultsTwo‐hundred‐and‐seventy‐nine proteins are differentially expressed between groups. Principal component analysis shows significant differences between groups. IPA shows specific process networks such as actin cytoskeleton and integrin signaling. Panther and David software show predominant biological processes such as cellular and metabolic processes. TGF‐ß enhances protein synthesis and protein pathways. IPA and RTCA suggest the involvement of epidermal growth factor receptor (EGFR) and phosphatidylinositol 3 kinase (Pi3K).Conclusions and clinical relevanceThat the proteome of fibroblasts differs between SSc patients and HC is confirmed, and it is demonstrated that fibroblasts exacerbate their proteomic phenotype upon stimulation with TGF‐ß. EGFR and Pi3K are highlighted as proteins of interest in SSc fibroblasts.
MALDI‐TOF MS‐Based Identification of Melanized Fungi is Faster and Reliable After the Expansion of In‐House Database
Authors: Paul Saikat , Singh Pankaj , Sharma Savitri , Prasad Gandham Satyanarayana , Rudramurthy Shivaprakash Mandya , Chakrabarti Arunaloke , Ghosh Anup K. 
Published: August 2018

PurposeInvasive fungal infections caused by melanized fungi are a growing concern. Rapid and reliable identification plays an important role in optimizing therapy. Matrix‐assisted laser desorption/ionization–time‐of‐flight mass spectrometry (MALDI‐TOF MS)‐based identification has emerged as a faster and more accurate diagnostic technique. However, lack of a protein extraction protocol and limited database restricts the identification of melanized fungi by MALDI‐TOF MS. The study is designed to standardize protein extraction protocol, to enrich the existing, and to create an in‐house database for the rapid identification of melanized fungi.Experimental designIn this study, 59 sequence‐confirmed, melanized fungi were used to expand and to create an in‐house database using a modified protein extraction protocol. A total of 117 clinical isolates are further used to validate the created database.ResultUsing existing Bruker database, only 29(24.8%) out of 117 moulds could be identified. However, all the isolates are identified accurately by supplementing the Bruker database with the created in‐house database. MALDI‐TOF MS takes significantly lesser time for identification compared to DNA sequencing.Conclusion and clinical relevanceAn expanded database with modified protein extraction protocol can reduce significant time to identify melanized fungi by MALDI‐TOF MS.
The Research Development of Quantum Dots in Electrochemical Energy Storage
Authors: Wu Ping , Xu Yuxia , Zhan Jingyi , Li Yan , Xue Huaiguo , Pang Huan 
Published: August 2018

AbstractQuantum dots, which are made from semiconductor materials, possess tunable physical dimensions and outstanding optoelectronic characteristics, and they have aroused widespread interest in recent years. In addition to applications in biomolecular analysis, sensors, organic photovoltaic devices, fluorescence, solar cells, photochemical reagents, light‐emitting diodes, and catalysis, quantum dots have attracted mounting attention in the field of electrochemical energy storage owing to their size confinement and anisotropic geometry. In this review, a comprehensive summary is given and the research progress of the study of quantum dots for batteries and electrochemical capacitors in recent years, including their synthesis methods, micro/nanostructural features, and electrochemical performance, is appraised.
Neutrophil‐Based Delivery Systems for Nanotherapeutics
Authors: Han Yu , Zhao Ruibo , Xu Feng 
Published: August 2018

AbstractNeutrophils, the most abundant leukocytes (50–70% of the total leukocytes in circulation), are the major type of cells recruited to sites of inflammation during infection and tumorigenesis, suggesting that neutrophils could contribute to nanotherapeutics for inflammation and cancer therapy. Neutrophil‐based delivery has shown great potential in circumventing nanotherapeutics limitations, such as low biocompatibility, short circulation time, and immunogenicity of nanomaterials. In this review, the current development of neutrophil‐based nanotherapeutic drugs in the treatment of inflammatory diseases and cancers is summarized. These successful neutrophil‐based nanotherapeutic systems indicate that introducing functional nanomaterials into neutrophils and neutrophil‐based vesicles may be a promising strategy for improving the nanotherapeutics in more complex conditions. The integration between neutrophils and nanomaterials will create more opportunities for future materials and medical studies.
Light‐Triggered Biomimetic Nanoerythrocyte for Tumor‐Targeted Lung Metastatic Combination Therapy of Malignant Melanoma
Authors: Liu Wen , Ruan Miaoliang , Wang Yanming , Song Rongguang , Ji Xin , Xu Jiake , Dai Jian , Xue Wei 
Published: August 2018

AbstractRed blood cell (RBC) membrane‐cloaked nanoparticles, reserving the intact cell membrane structure and membrane protein, can gain excellent cell‐specific functions such as long blood circulation and immune escape, providing a promising therapy nanoplatform for drug delivery. Herein, a novel RBC membrane biomimetic combination therapeutic system with tumor targeting ability is constructed by embedding bovine serum albumin (BSA) encapsulated with 1,2‐diaminocyclohexane‐platinum (II) (DACHPt) and indocyanine green (ICG) in the targeting peptide‐modified erythrocyte membrane (R‐RBC@BPtI) for enhancing tumor internalization and synergetic chemophototherapy. R‐RBC@BPtI displays excellent stability and high encapsulation efficiency with multiple cores enveloped in the membrane. Benefited from the stealth functionality and targeting modification of erythrocyte membranes, R‐RBC@BPtI can significantly promote tumor targeting and cellular uptake. Under the near‐infrared laser stimuli, R‐RBC@BPtI presents remarkable instability by singlet oxygen and heat‐mediated cleavage so as to trigger effective drug release, thereby achieving deep penetration and accumulation of DACHPt and ROS in the tumor site. Consequently, R‐RBC@BPtI with tumor‐specific targeting ability accomplishes remarkable ablation of tumors and suppressed lung metastasis in vivo by photothermal and chemotherapy combined ablation under phototriggering. This research provides a novel strategy of targeted biomimetic nanoplatforms for combined cancer chemotherapy–phototherapy.
Surface‐Enhanced Raman Nanoprobes with Embedded Standards for Quantitative Cholesterol Detection
Authors: Jiang Xin , Tan Ziyang , Lin Li , He Jing , He Chang , Thackray Benjamin D. , Zhang Yuqing , Ye Jian 
Published: August 2018

AbstractCholesterol is an essential molecule for many processes in the human body and many diseases such as hypertension, coronary heart disease, atherosclerosis, and lipid metabolism dysfunction can be detected in their early stages by monitoring intracellular cholesterol levels. Herein, metallic surface‐enhanced Raman scattering (SERS) core–shell nanoparticles with an embedded standard are designed for nondestructive detection of H2O2 and cholesterol. A classical least squares (CLS) spectral fitting method allows one to accurately extract the SERS signals of internal standards and target molecules from the multiplexed spectra. The embedded internal standard can be used to calibrate the SERS signals, removing fluctuations induced by differing measurement conditions and local states of the nanoparticles, such as aggregation. Thus, SERS signal reproducibility is improved and a better linear relationship in the working curve of detection is achieved. Using these SERS nanoprobes quantitative detection of H2O2 and cholesterol in solution and inside live cells at a single‐cell level is demonstrated.
Bimetallic MOF‐Derived FeCo‐P/C Nanocomposites as Efficient Catalysts for Oxygen Evolution Reaction
Authors: Hong Wei , Kitta Mitsunori , Xu Qiang 
Published: August 2018

AbstractOxygen evolution reaction (OER) demands cost‐effective electrocatalysts with high catalytic performance. In this effort, metal–organic framework (MOF)‐derived nanocomposites are presenting promising prospects to achieve this goal. Herein, FeCo bimetallic MOFs with different compositions are prepared through a sodium hydroxide assisted approach. By means of a successive carbonization and phosphating reaction, a series of MOF‐derived multicomponent products are synthesized. The resultant P‐doped products present enhance electrocatalytic performance for OER in alkaline electrolyte in comparison with a commercial RuO2 catalyst, which paves the way for their practical applications for water splitting. The developed method herein also offers an opportunity for the large‐scale preparation of MOF‐derived product toward energy conversion applications.
Acute renal toxicity of sodium chlorate: Redox imbalance, enhanced DNA damage, metabolic alterations and inhibition of brush border membrane enzymes in rats
Authors: Ali Shaikh Nisar , Arif Hussain , Khan Aijaz Ahmed , Mahmood Riaz 
Published: August 2018

AbstractSodium chlorate (NaClO3) is widely used in paper and pulp industries and as a non‐selective herbicide. Humans can be exposed to NaClO3 through contaminated drinking water due to its improper and unchecked usage in industries and as herbicide. NaClO3 is also present as a major stable by‐product in drinking water that has been disinfected with chlorine dioxide. In this study, we have investigated the effect of a single acute oral dose of NaClO3 on rat kidney. Adult male Wistar rats were divided into one control and four NaClO3 treated groups that were orally given different doses of NaClO3 and euthanized 24 hr after the treatment. Oral administration of NaClO3 resulted in increased hydrogen peroxide levels, lipid, and protein oxidation while thiol and glutathione content and activities of brush border membrane enzymes were decreased in kidney in a NaClO3 dose‐dependent manner. Significant alterations in the activities of enzymes involved in carbohydrate metabolism and antioxidant defense were also observed. Administration of NaClO3 induced DNA fragmentation and increased DNA–protein cross‐linking. Histological studies showed marked damage in kidney from NaClO3 treated animals. These results strongly suggest that NaClO3 induces nephrotoxicity via redox imbalance that results in DNA and membrane damage, metabolic alterations and brush border membrane enzyme dysfunction.
Effects of perinatal undernutrition on social transmission of food preference in adult male Wistar rats
Authors: Rubio Lorena , Téllez Laura , Regalado Mirelta , Torrero Carmen , Salas Manuel 
Published: August 2018

AbstractNutrition plays a fundamental role in learning and memory, and early experimental undernutrition interferes with brain memory processes. Social transmission of food preference (STFP) is a natural olfactory paired‐associate learning test that has not been used to assess the effects of early undernutrition on memory consolidation. Male Wistar rats were randomly divided into two groups: control and early undernourished. The underfed rats received different percentages of a balanced diet during gestation. After birth, pups were underfed by alternating every 12 h between two lactating dams, one with ligated nipples. Weaning occurred on PD 25 followed by an ad lib diet until PD 90. Demonstrator rats were given powdered food mixed with cinnamon, followed by a 30‐min interaction with an underfed observer. Thereafter, the observer had two choices of food: cinnamon or cocoa. During the food preference test, control and underfed OBS rats preferred the food containing cinnamon. Through social interaction, the UG OBS rats showed latency for head contacts and oral‐nasal investigation was higher in the underfed rats; only head contacts and oral‐nasal investigation frequency was lower; with the duration lower, but oral‐nasal investigation duration was higher (p < 0.05). In the preference phase, the OBS underfed rat latencies for both stimuli were prolonged, the frequency lower only for cocoa, and the duration lower for cinnamon but higher for cocoa (p < 0.05). Findings suggested that early undernutrition interfered with the attentive social transmission to take a decision during the preference phase, but not with the short‐term memory consolidation of social food preference.
Best practice guidelines for studies of parasite community ecology
Authors: Poulin R. 
Published: August 2018

AbstractIn recent decades, parasite community ecology has produced hundreds of studies on an ever-growing number of host species, and developed into an active sub-discipline of parasitology. However, this growth has been characterized by a lack of standards in the practices used by researchers, with many common approaches being flawed, unjustified or misleading. Here, in the hope of promoting advances in the study of parasite community ecology, I identify some of the most common errors or weaknesses in past studies, and propose ten simple rules for best practice in the field. They cover issues including, among others, taxonomic resolution, proper and justifiable analytical methods, higher-level replication, controlling for sampling effort or species richness, accounting for spatial distances, using experimental approaches, and placing raw data in the public domain. While knowledge of parasite communities has expanded in breadth, with more and more host species being studied, true progress has been very limited with respect to our understanding of fundamental general processes shaping these communities. It is hoped that the guidelines presented here can direct researchers away from the entrenched use of certain approaches flawed in design, analysis or interpretation, by offering a more rigorous and standardized set of practices, and, hopefully, a way forward.
Kinematic analysis of the 3-RPS-3-SPR series–parallel manipulator
Authors: Nayak Abhilash , Caro Stéphane , Wenger Philippe 
Published: August 2018

SUMMARYThis paper deals with the kinematic analysis and enumeration of singularities of the six degree-of-freedom 3-RPS-3-SPR series–parallel manipulator (S–PM). The characteristic tetrahedron of the S–PM is established, whose degeneracy is bijectively mapped to the serial singularities of the S–PM. Study parametrization is used to determine six independent parameters that characterize the S–PM and the direct kinematics problem is solved by mapping the transformation matrix between the base and the end-effector to a point in ℙ7. The inverse kinematics problem of the 3-RPS-3-SPR S–PM amounts to find the location of three points on three lines. This problem leads to a minimal octic univariate polynomial with four quadratic factors.
Intervening in cultural development: The case of ethnic–racial identity
Authors: Umaña-Taylor Adriana J. 
Published: August 2018

AbstractThe literature on developmental psychopathology has been criticized for its limited integration of culture and, particularly, the lack of research addressing cultural development in relation to psychopathology. In this paper, I present how the study of ethnic–racial identity provides a heuristic model for how culture can be examined developmentally and in relation to psychopathology. In addition, I introduce the Identity Project intervention program and discuss how its findings provide empirical support for the notions that cultural development can be modified with intervention, and that such modifications can lead to psychosocial benefits for adolescents. Finally, I discuss existing challenges to advancing this work and important future directions for both basic and translational research in this area.
„Seefahrercamp“ – Effektivität eines kognitiv-behavioralen Behandlungsprogramms für Kinder mit Traumafolgestörungen von 5 bis 13 Jahren
Authors: Kröger Christoph , Ulbrich Laura , Ahrens-Eipper Sabine , Nelius Katrin 
Published: August 2018

Zusammenfassung. Ein traumafokussiertes kognitiv-behaviorales Behandlungsprogramm mit spielerischen Therapiebausteinen wurde für Kinder mit Traumafolgestörungen und ihre Bezugspersonen entwickelt. Untersucht wurde, ob eine Verminderung der posttraumatischen und phobischen Symptomatik sowie weiterer Verhaltensauffälligkeiten erreicht werden konnte. Die Daten von 47 Kindern im Alter von 5 bis 13 Jahren (61.7 % männlich) wurden vor und nach der Therapie sowie sechs Monate im Anschluss erhoben. Nach der Behandlung waren die selbstbeurteilten posttraumatischen und fremdbeurteilten phobischen Symptome, sowie die fremdbeurteilten Auffälligkeiten signifikant verbessert. Die Effektstärken fielen erwartungsgemäß moderat bzw. hoch aus; die Responseraten für die posttraumatischen und phobischen Symptome betrugen 70.4 % bzw. 19.2 %. Alle Kinder wiesen am Behandlungsende eine Remission der posttraumatischen Symptome auf. Das Behandlungsprogramm sollte zukünftig in randomisiert-kontrollierten Studien untersucht werden.
The Crust and Upper Mantle Structure of Central and West Antarctica From Bayesian Inversion of Rayleigh Wave and Receiver Functions
Authors: Shen Weisen , Wiens Douglas A. , Anandakrishnan Sridhar , Aster Richard C. , Gerstoft Peter , Bromirski Peter D. , Hansen Samantha E. , Dalziel Ian W. D. , Heeszel David S. , Huerta Audrey D. , Nyblade Andrew A. , Stephen Ralph , Wilson Terry J. , Winberry J. Paul 
Published: August 2018

AbstractWe construct a new seismic model for central and West Antarctica by jointly inverting Rayleigh wave phase and group velocities along with P wave receiver functions. Ambient noise tomography exploiting data from more than 200 seismic stations deployed over the past 18 years is used to construct Rayleigh wave phase and group velocity dispersion maps. Comparison between the ambient noise phase velocity maps with those constructed using teleseismic earthquakes confirms the accuracy of both results. These maps, together with P receiver function waveforms, are used to construct a new 3‐D shear velocity (Vs) model for the crust and uppermost mantle using a Bayesian Monte Carlo algorithm. The new 3‐D seismic model shows the dichotomy of the tectonically active West Antarctica (WANT) and the stable and ancient East Antarctica (EANT). In WANT, the model exhibits a slow uppermost mantle along the Transantarctic Mountains (TAMs) front, interpreted as the thermal effect from Cenozoic rifting. Beneath the southern TAMs, the slow uppermost mantle extends horizontally beneath the traditionally recognized EANT, hypothesized to be associated with lithospheric delamination. Thin crust and lithosphere observed along the Amundsen Sea coast and extending into the interior suggest involvement of these areas in Cenozoic rifting. EANT, with its relatively thick and cold crust and lithosphere marked by high Vs, displays a slower Vs anomaly beneath the Gamburtsev Subglacial Mountains in the uppermost mantle, which we hypothesize may be the signature of a compositionally anomalous body, perhaps remnant from a continental collision.
Seismic Attenuation From Ambient Noise Across the North Sea Ekofisk Permanent Array
Authors: Allmark Claire , Curtis Andrew , Galetti Erica , de Ridder Sjoerd 
Published: August 2018

AbstractQuality factor (Q) or equivalently attenuation
describes the amount of energy lost per cycle as a wave travels through a medium. This is important to correct seismic data amplitudes for near‐surface effects, to locate subsurface voids or porosity, to aid seismic interpretation, or for characterizing other rock and fluid properties. Seismic attenuation can be variable even when there are no discernible changes in seismic velocity or density (Yıldırım et al., 2017, https://doi.org/10.1016/j.jappgeo.2016.11.010) and so provides independent information about subsurface heterogeneity. This study uses ambient noise recordings made on the Ekofisk Life of Field Seismic array to estimate Q structure in the near surface. We employ the method of X. Liu et al. (2015, https://doi.org/10.1093/gji/ggv357), which uses linear triplets of receivers to estimate Q—ours is the first known application of the method to estimate the Q structure tomographically. Estimating Q requires an estimate of phase velocity which we obtain using the method of Bloch and Hales (1968, https://pubs.geoscienceworld.org/ssa/bssa/article‐abstract/58/3/1021/116607/) followed by traveltime tomography. The Q structure at Ekofisk has features which can be related to local geology, showing that surface ambient noise recordings may provide a new and robust method to image Q. Our results suggest that there is a nonlinear relationship between Q and compression. They also may explain why it has been found that in the period range of 1 to 2 s considered here, ambient noise cross correlations along paths that span the North Sea Basin are unreliable: Such Q values would attenuate almost all ambient seismic energy during such a traverse.