bluuebunny/crossref_metadata_2025_split huggingface dataset:
POLARIMETRIC RESEARCH OF PHARMACEUTICAL SUBSTANCES IN AQUEOUS SOLUTIONS WITH DIFFERENT WATER ISOTOPOLOGUES RATIO
Authors: Syroeshkin A. V. , Pleteneva T. V. , Uspenskaya E. V. , Levitskaya O. V. , Tribot-laspiere M. A. , Zlatsky I. A. , Khodorovich N. A. , Nikifirova M. V. , Zaytseva S. A. 
Published: September 2018

Objective: Methodology development for quality control of optically active pharmaceutical substances based on water isotopologues.Methods: Solutions of L-ascorbic acid, glucose, galactose and valine stereoisomers were prepared using deuterium depleted water (DDW-«light» water, D/H=4 ppm), natural deionized high-ohmic water (BD, D/H=140 ppm), heavy water (99.9% D2O). The optical rotation was observed using an automatic polarimeter Atago POL-1/2. The size distribution of giant heterogeneous clusters (GHC) of water was recorded by low angle laser light scattering (LALLS) method.Results: The infringement of Biot’s Law was found for solutions of ascorbic acid, expressed in the absence of a constant value of the specific optical rotation at a concentration of below 0.1%, depends on the D/H ratio. The inequality was established in absolute values of optical rotation for L-and D-isomers of valine in solutions with different ratios of hydrogen isotopologues. The mutarotation of glucose confirmed the first-order kinetics, and the activation energies were statistically distinguishable for BD and DDW. The mutarotation of the natural galactose D-isomer proceeded with a lower energy consumption compared to the L-isomer. In heavy water, the mutarotation of monosaccharides had different kinetic mechanisms. Polarimetric results correlated with the number and size of GHC, which confirmed the possibility of chiral solvent structures induction by optically active pharmaceutical substances.Conclusion: In the optically active pharmaceutical substances quality control there should be considered the contribution of induced chiral GHC of water to the optical rotation value that depends on the isotopic D/H ratio, the substance nature and the form of its existence at a given pH.
Analyzing Two Investments—An Instructional Case to Introduce Basic Financial Accounting Concepts
Authors: Bailey Wendy J. , Samuels Janet A. 
Published: September 2018

ABSTRACT
This case introduces basic financial accounting concepts to graduate business students in an accounting orientation session (i.e., “boot camp”). Students assume they have invested in two cupcake businesses in Paris and they now want to determine which business performed best. Instructors can use this case, which provides students an opportunity to compare two businesses, to achieve several learning objectives including those related to accrual accounting (i.e., when to record transactions), the legal aspects of business (i.e., company structure, stock ownership, international accounting), and the use of estimates in financial reporting (i.e., depreciation, bad debts). This case also introduces students to the three basic financial statements (i.e., balance sheet, income statement, statement of cash flows), and the evaluation of financial results (i.e., net income versus cash flow, ratios). We have found that this simple, straightforward case helps students feel more confident when working with basic financial accounting concepts.
Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study
Authors: Klubo-Gwiezdzinska Joanna , Lange Maria , Cochran Elaine , Semple Robert K. , Gewert Cornelia , Brown Rebecca J. , Gorden Phillip 
Published: September 2018

OBJECTIVEType B insulin resistance due to autoantibodies against the insulin receptor is characterized by diabetes refractory to massive doses of insulin, severe hypercatabolism, hyperandrogenism, and a high mortality rate. We analyzed the efficacy of combined immunosuppressive therapy in the management of this extreme form of diabetes.RESEARCH DESIGN AND METHODSWe performed a prospective cohort study including patients with confirmed insulin receptor autoantibodies, monitored for median 72 months (25th, 75th interquartile range 25, 88), and treated with rituximab, high-dose pulsed steroids, and cyclophosphamide until remission, followed by maintenance therapy with azathioprine. Remission was defined as the amelioration of the hyperglycemia and discontinuation of insulin and/or normalization of hyperandrogenemia.RESULTSAll data are given as median (25th, 75th interquartile range). Twenty-two patients aged 42 (25, 57) years, 86.4% women, fulfilled inclusion criteria. At baseline, fasting glucose was 307 (203, 398) mg/dL, HbA1c was 11.8% (9.7, 13.6), total testosterone (women) was 126 (57, 571) ng/dL (normal 8–60), and daily insulin requirement was 1,775 (863, 2,700) units. After 5 (4, 6.3) months, 86.4% (19 of 22) of patients achieved remission, documented by discontinuation of insulin in all patients, normal fasting glucose of 80 (76, 92) mg/dL, HbA1c of 5.5% (5.2, 6), and testosterone (women) of 28 (20, 47) ng/dL. During follow-up of 72 (25, 88) months, 13.6% (3 of 22) of patients developed disease recurrence, occurring 24 (22, 36) months after initial remission, which responded to repeated therapy. None of the patients died.CONCLUSIONSCombined immunosuppressive therapy has changed the natural history of this disease, from 54% mortality to a curable form of diabetes and, as such, should be recommended in patients with type B insulin resistance.
Association of Time in Range, as Assessed by Continuous Glucose Monitoring, With Diabetic Retinopathy in Type 2 Diabetes
Authors: Lu Jingyi , Ma Xiaojing , Zhou Jian , Zhang Lei , Mo Yifei , Ying Lingwen , Lu Wei , Zhu Wei , Bao Yuqian , Vigersky Robert A. , Jia Weiping 
Published: September 2018

OBJECTIVE
Continuous glucose monitoring (CGM) has provided new measures of glycemic control that link to diabetes complications. This study investigated the association between the time in range (TIR) assessed by CGM and diabetic retinopathy (DR).

RESEARCH DESIGN AND METHODS
A total of 3,262 patients with type 2 diabetes were recruited. TIR was defined as the percentage of time spent within the glucose range of 3.9–10.0 mmol/L during a 24-h period. Measures of glycemic variability (GV) were assessed as well. DR was determined by using fundus photography and graded as 1) non-DR; 2) mild nonproliferative DR (NPDR); 3) moderate NPDR; or 4) vision-threatening DR (VTDR).

RESULTS
The overall prevalence of DR was 23.9% (mild NPDR 10.9%, moderate NPDR 6.1%, VTDR 6.9%). Patients with more advanced DR had significantly less TIR and higher measures of GV (all P for trend &lt;0.01). The prevalence of DR on the basis of severity decreased with ascending TIR quartiles (all P for trend &lt;0.001), and the severity of DR was inversely correlated with TIR quartiles (r = −0.147; P &lt; 0.001). Multinomial logistic regression revealed significant associations between TIR and all stages of DR (mild NPDR, P = 0.018; moderate NPDR, P = 0.014; VTDR, P = 0.019) after controlling for age, sex, BMI, diabetes duration, blood pressure, lipid profile, and HbA1c. Further adjustment of GV metrics partially attenuated these associations, although the link between TIR and the presence of any DR remained significant.

CONCLUSIONS
TIR assessed by CGM is associated with DR in type 2 diabetes.
El Movimiento Nacional Justicialista: una experiencia de organización peronista en tiempos de proscripción (1967-1968)
Authors: Marcilese José Bernardo 
Published: September 2018

Este artículo se propone estudiar a la dinámica interna del peronismo durante los años de la “Revolución Argentina”, a partir de la experiencia del Movimiento Nacional Justicialista, la estructura organizativa que integró a la rama política a partir de 1968. Con ese fin se analizan las relaciones internas entre las diversas facciones peronistas y la vinculación de la actividad política con los procesos sindicales. Del mismo modo, se pondera el creciente protagonismo de los sectores juveniles, entre los cuales se destaca el progresivo avance de la línea revolucionaria, y la participación activa de la rama femenina. Ciertamente, durante la etapa que se iniciar con el golpe militar diversos grupos políticos peronistas tuvieron una activa participación tendiente a reorganizar el movimiento con fines electorales
En este sentido, la investigación pretende indagar en el accionar de los diversos grupos que integraban la rama política del peronismo, particularmente en el distrito bonaerense, para lo cual se considerará en forma específica el carácter de las prácticas que configuraban su accionar y las estrategias que asumen frente al contexto adverso que representa el Onganiato.
Pengaruh Metode Kooperatif dan Komando Terhadap Keterampilan Teknik Dasar Bermain Sepakbola
Authors: Gazali Novri 
Published: September 2018

Tujuan penelitian ini adalah mengungkap pengaruh metode kooperatif dan metode komando terhadap keterampilan teknik dasar bermain sepakbola. Jenis penelitian ini adalah eksperimen semu (Quasy Eksperiment), populasi penelitian ini adalah siswa putra SD Negeri 021 Kecamatan Kuantan Tengah Kabupaten Kuansing Provinsi Riau yang berjumlah 42 orang, sedangkan sampel dalam penelitian ini adalah 28 orang siswa setelah menggunakan teknik purposive sampling. Instrumen penelitian yang digunakan adalah tes keterampilan sepakbola usia 10 - 12 tahun, data dianalisis menggunakan statistik uji normalitas dan uji-t. Hasil analisis penelitian menunjukkan bahwa: (1) Terdapat pengaruh metode kooperatif yang signifikan terhadap keterampilan teknik dasar bermain sepakbola, dari rata-rata (mean) 366,07 pada tes awal menjadi 390,36 pada tes akhir, dengan beda mean 24,29 (thitung = 10,29 > ttabel = 1,771), (2) Terdapat pengaruh metode komando yang signifikan terhadap keterampilan teknik dasar bermain sepakbola, dari rata-rata (mean) 363,36 pada tes awal menjadi 376,79 pada tes akhir, dengan beda mean 16,43 (thitung = 5,15 > ttabel= 1.771), (3) Metode kooperatif lebih efektif dari pada metode komando dalam meningkatkan keterampilan teknik dasar bermain sepakbola. Rata-rata peningkatan keterampilan teknik dasar bermain sepakbola dengan menggunakan metode kooperatif adalah 24,29, sementara peningkatan keterampilan teknik dasar bermain sepakbola dengan menggunakan metode komando hanya 16,43, dengan beda mean sebesar 7,86 (thitung = 2,64 > ttabel = 1,771).
Eigencages: Learning a Latent Space of Porous Cage Molecules
Authors: Sturluson Arni , Huynh Melanie T. , York Arthur H. P. , Simon Cory 
Published: September 2018

Porous organic cage molecules harbor nano-sized cavities that can selectively adsorb gas molecules, lending them applications in separations and sensing. The geometry of the cavity strongly influences adsorptive selectivity.For comparing cages and predicting their adsorption properties, we embed/encode the cavities of a set of 74 porous organic cage molecules into a low-dimensional, latent "cage space".We first scan the cavity of each cage to generate a 3D image of its porosity. Leveraging the singular value decomposition, in an unsupervised manner, we then learn across all cages an approximate, lower-dimensional subspace in which the 3D cage cavity images lay. The "eigencages" are the set of characteristic 3D cage cavity images that span this lower-dimensional subspace. A latent representation/encoding of each cage then follows from expressing it as a combination of the eigencages.We show that the learned encoding captures salient features of the cavities of porous cages and is predictive of properties of the cages that arise from cavity shape.
Status Pemanfaatan Perikanan Tuna Madidihang (Thunnus albacares) Berdasarkan Model Biologi Schaefer
Authors: Wiranata Abgusta Fajri , Wiryawan Budy - , Wisudo Sugeng Hari , Zulbainarni Nimmi - 
Published: September 2018

There are two types of population growth function of the basic formulation of Schaefer’s biology model, however in this study there is a difference in form and value of “r” as one of a biology parameter. In addition to the difference in the method by calculating the process of a and b coefficient. The calculating process of a and b coefficient in Schaefer’s biology model was conducted through linear regression which has not yet been exact. This is due to the model itself which is quadratic. Therefore to provide the solution is through quadratic process. The linear regression shows the value of fmsy and Ymsy 1.40 and 1.34 times smaller than quadratic process respectively. Based on the two graphs from the calculating process of a and b coefficient, it can be concluded that the utilization of yellowfin tuna fishery was still not optimal. According to the result based on the linear and quadratic regression, the maximum production of yellowfin tuna can be increased to 664,037 and 877,340 kg.Keywords: Population growth function, Schaefer’s Biology Model, Utilization status, Yellowfin tunaABSTRAKDua jenis fungsi pertumbuhan populasi menjadi dasar pembentukan model biologi Schaefer, namun dalam kajian ini terdapat perbedaan dalam bentuk dan nilai r sebagai parameter biologi ditambah juga berdasarkan perbedaan metode perhitungan koefisien a dan b. Metode perhitungan koefisien a dan b model biologi Schaefer melalui regresi linear masih kurang tepat, karena model biologi Schaefer berbentuk kuadratik, sehingga penyelesaiannya harus melalui proses kuadratik. Nilai fmsy dan Ymsy dari proses regresi linear memiliki nilai 1,40 dan 1,34 kali lebih rendah dari proses kuadratik. Berdasarkan kedua kurva dari kedua metode perhitungan koefisien a dan b, maka status pemanfaatan perikanan tuna madidihang diduga masih belum optimal. Sehingga berdasarkan proses regresi linear dan kuadratik, maka produksi maksimal tuna madidihang masih dapat ditingkatkan sampai dengan 664.037 dan 877.340 kg.Kata kunci: Fungsi pertumbuhan populasi, Model biologi Schaefer, Status pemanfaatan Tuna madidihang
PENGELOLAAN PERIKANAN KARANG DI TAMAN NASIONAL WAKATOBI: PERSPEKTIF AKTOR DAN AGEN
Authors: Patanda Mercy - , Wisudo Sugeng Hari , Monintja Daniel Rudolf , Wiryawan Budy - 
Published: September 2018

Stakeholders, who are agents and actors in this matter play an important role in the management of reef fisheries in Wakatobi National Park. This study aims to identify the agents and actors in Wakatobi Regency and to identify similarities and differences of the perception between agents and actors in the management of conservation areas. The method used is Principal Component Analysis (PCA). The result showed that there was a similar perception between agent and actor in which that the conservation gives benefit for the society in Wakatobi and the lack of regulation in Wakatobi Regency. Different perceptions between actors and agents occurred due to fishermen intention to fully utilize the resources for their welfare while the government intents to limit the fishing area in order to preserve the natural resources and the environment. Therefore, management related to the regulation on legal-size of fish and the effectiveness of marine protected areas are needed. Keywords: Stakeholders, Coral Reef, Conservation, WakatobiABSTRAKPemangku kepentingan sangat berperan penting dalam pengelolaan perikanan karang di Taman Nasional Kabupaten Wakatobi. Tujuan penelitian adalah mengidentifikasi agen dan aktor yang berada di Kabupaten Wakatobi serta melihat persamaan dan perbedaan persepsi antara agen dengan aktor dalam pengelolaan kawasan konservasi. Penelitian ini menggunakan analisis Principal Component Analysis (PCA). Hasil kajian menunjukkan adanya persamaan persepsi antara agen dan aktor yaitu konservasi memberikan manfaat bagi masyarakat yang ada di Wakatobi dan masih kurangnya peraturan di Kabupaten Wakatobi. Perbedaan persepsi pada aktor dan agen karena nelayan ingin memanfaatkan perairan Taman nasional Wakatobi semaksimal mungkin untuk kesejahteraan nelayan sedangkan pemerintah membatasi wilayah penangkapan dalam rangka menjaga sumber daya alam dan lingkungannya sehingga perlu tindakan pengelolaan yaitu penentuan ukuran ikan yang tertangkap dan pengefektifan daerah perlindungan laut.Kata kunci: Pemangku Kepentingan, Perikanan Karang, Konservasi, Wakatobi
Konflik Tata Ruang Kehutanan Dengan Tata Ruang Wilayah (Studi Kasus Penggunaan Kawasan Hutan Tidak Prosedural Untuk Perkebunan Sawit Provinsi Kalimantan Tengah)
Authors: Setiawan Eko N , Maryudi Ahmad , Purwanto Ris H , Lele Gabriel 
Published: September 2018

AbstractLaw No. 26 Year 2007 on Spatial Planning (UUPR) mandated that all levels of government administration, ranging from the national, provincial, district/ city are obligated to prepare Spatial Plan (RTR). Until 2012, Central Kalimantan is one of the provinces which have not completed its Spatial Plan; one of the reasons was the lack of spatial integration of forestry spatial planning and provincial spatial planning of Central Kalimantan.The absence of spatial integration of forestry and provincial spatial planning of Central Kalimantan has the implication in triggering conflicts of land use. Forest areas were converted into oil palm plantations without any official procedures. There are 282 units of oil palm companies, occupying 3.9 millions hectares of forest area, with non-procedural procedures to convert forest area into oil palm plantation.To resolve this problem, the Government has revised the regulation of forest conversion by issuing PP No. 60/2012, provides opportunities for oil palm plantations, which under the Law of Forestry located in forest area but based on RTRWP of Central Kalimantan lies on APL or cultivation area, given the opportunity to re-apply the permit/license. IntisariUndang- Undang No. 26 Tahun 2007 tentang Penataan Ruang (UUPR) mengamanatkan bahwa semua tingkatan administrasi pemerintahan, mulai dari nasional, provinsi, kabupaten/kota diwajibkan menyusun Rencana Tata Ruang (RTR). Kalimantan Tengah sampai dengan tahun 2012 merupakan salah satu Provinsi yang belum menyelesaikan Tata Ruang, salah satu penyebabnya karena belum adanya padu serasi antara tata ruang kehutanan dengan tata ruang Provinsi Kalimantan Tengah.Implikasi dari tidak adanya padu serasi antara tata ruang kehutanan dengan tata ruang provinsi Kalimantan Tengah adalah terjadinya konflik dalam penggunaan ruang, dimana terjadi penggunaan kawasan hutan tidak prosedural untuk perkebunan sawit di dalam kawasan hutan di Provinsi Kalimantan Tengah sebanyak 282 unit perusahaan sawit seluas 3,9 juta hektar.Upaya penyelesaian permasalahan penggunaan kawasan hutan untuk perkebunan sawit di Provinsi Kalimantan Tengah diakukan dengan revisi kebijakan tentang alih fungsi hutan PP nomor 60 tahun 2012 yang memberikan kesempatan bagi perkebunan sawit yang berdasarkan Undang-Undang Kehutanan berada di dalam kawasan hutan namun berdasarkan RTRWP Provinsi Kalimantan Tengah berada di kawasan APL maupun budidaya, diberikan kesempatan untuk mengurus perijinannya.
Upper Limits on the Rapid Cooling of the Central Compact Object in Cas A
Authors: Posselt B. , Pavlov G. G. 
Published: September 2018

Abstract
The Central Compact Object (CCO) in the Cassiopeia A supernova remnant is most likely a very young (≈300 years) neutron star. If a previously reported decrease of its surface temperature by 4% in 10 years could be confirmed, it would have profound theoretical implications for neutron-star physics. However, the temperature decrease was inferred from Chandra ACIS data affected by instrumental effects that could cause time-dependent spectral distortions. Employing a different instrument setup that minimizes spectral distortions, our 2006 and 2012 Chandra spectra of the CCO did not show a statistically significant temperature decrease. Here, we present additional observations from 2015 taken in the same instrument mode. During the time span of 8.5 years, we detect no significant temperature decrease, using either carbon or hydrogen atmosphere models in the X-ray spectral fits. Our conservative 3σ upper limits correspond to <3.3% and <2.4% temperature decreases in 10 years for carbon atmosphere model fits with varying or constant values of the absorbing hydrogen column density, respectively. The recently revised model for the ACIS filter contaminant has a strong effect on the fit results, reducing the significance of the previously reported temperature and flux changes. We expect that a further improved contaminant model and longer time coverage can significantly lower the upper limits in the future.
An Analytical Portrait of Binary Mergers in Hierarchical Triple Systems
Authors: Randall Lisa , Xianyu Zhong-Zhi 
Published: September 2018

Abstract
With better statistics and precision, eccentricity could prove to be a useful tool for understanding the origin and environment of binary black holes. Hierarchical triples in particular, which might be abundant in globular clusters and galactic nuclei, could generate observably large eccentricity at LIGO and future gravitational wave detectors. Measuring the eccentricity distribution accurately could help us probe the background and the formation of the mergers. In this paper we continue our previous investigation and improve our semianalytical description of the eccentricity distribution of mergers of hierarchical triple systems. Our result, which further reduces the reliance on numerical simulations, could be useful for statistically distinguishing different formation channels of observed binary mergers.
On the CGM Fundamental Plane: The Halo Mass Dependency of Circumgalactic H i
Authors: Bordoloi Rongmon , Prochaska J. Xavier , Tumlinson Jason , Werk Jessica K. , Tripp Todd M. , Burchett Joseph N. 
Published: September 2018

Abstract
We analyze the equivalent widths of H i

(

) absorption from the inner (R < 160 kpc) circumgalactic medium (CGM) of 85 galaxies at z ∼ 0 with stellar masses M
* ranging

. Across three orders of magnitude in stellar mass, the CGM of present-day galaxies exhibits a very high covering fraction of cool hydrogen gas (f

C
= 87 ± 4%) indicating that the CGM is ubiquitous in modern, isolated galaxies. When H i

is detected, its equivalent width declines with increasing radius regardless of the galaxy mass, but the scatter in this trend correlates closely with M
*. Using the radial and stellar mass correlations, we construct a planar surface describing the cool CGM of modern galaxies:

. The rms scatter around this bivariate relation is ∼0.2 dex. We interpret the explicit correlation between

and M* to arise from the underlying dark matter halo mass (M
halo), thereby suggesting a CGM fundamental plane between

, R, and M
halo. This correlation can be used to estimate the underlying dark matter halo mass from observations of saturated H i

in the CGM of a modern galaxy.