bluuebunny/crossref_metadata_2025_split huggingface dataset:
PlncRNA‐1 is overexpressed in retinoblastoma and regulates retinoblastoma cell proliferation and motility through modulating CBR3
Authors: Wang Shuna , Liu Jianwei , Yang Yang , Hao Fengqin , Zhang Laixia 
Published: August 2018

AbstractPlncRNA‐1 has been suggested to function as an oncogenic role in prostate cancer, colorectal cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma, and gastric cancer. The expression pattern of PlncRNA‐1 in retinoblastoma remained unknown. Therefore, the aim of this study was to explore the clinical significance of PlncRNA‐1 in retinoblastoma patient and the biological function and molecular mechanism of PlncRNA‐1 in regulating retinoblastoma cell proliferation, migration, and invasion. The results showed the level of PlncRNA‐1 expression was obviously increased in retinoblastoma tissues and cell lines compared with compared with normal retina tissues and retina cell lines, respectively. Meanwhile, patients with advanced stage retinoblastoma had higher levels of PlncRNA‐1 expression than patients with early stage retinoblastoma. There was an inverse correlation between PlncRNA‐1 expression and CBR3 expression in retinoblastoma tissues, and PlncRNA‐1 negatively regulated mRNA and protein expressions of CBR3. The in vitro experiments showed that down‐regulation of PlncRNA‐1 expression suppressed retinoblastoma cell proliferation, migration and invasion through up‐regulating CBR3. In conclusion, PlncRNA‐1 serves as an oncogenic lncRNA in regulating retinoblastoma cell proliferation, migration, and invasion through proliferation, migration, and invasion through up‐regulating CBR3. © 2018 IUBMB Life, 70(10):969–975, 2018
Three‐dimensional printing of poly(glycerol sebacate fumarate) gadodiamide‐poly(ethylene glycol) diacrylate structures and characterization of mechanical properties for soft tissue applications
Authors: Ravi Prashanth , Wright Jamie , Shiakolas Panos S. , Welch Tré R. 
Published: August 2018

AbstractBioresorbable materials have been frequently used to three‐dimensional (3D) print biomedical structures. In this study, we developed a technique to 3D print poly(glycerol sebacate fumarate) gadodiamide (Rylar)‐poly(ethylene glycol) diacrylate (PEGDA) samples and investigated their mechanical and thermal properties as a function of (PS) and ultraviolet intensity (UVI). The Young's modulus (E), ultimate tensile strength (UTS), failure strain (ɛF), and glass transition temperature (Tg) showed strong correlation with PS and UVI. Results showedEto be between 1.31 and 3.12 MPa, UTS between 0.07 and 0.43 MPa, andɛFbetween 7 and 20% with brittle failure. TheTgwas observed to lie between −54.48 and −49.10without secondary/tertiary transitions. Dominant elastic behavior was observed from the dynamic mechanical testing viscoelastic data. Testing results were used to develop a regression predictive model forEas a function of PS and UVI. The model performance was evaluated experimentally with an average absolute error of 3.62%. TheEand stress‐strain response of our 3D printed samples show agreement with published data for human tracheal cartilage, and the mechanical properties were comparable to other published soft polymeric scaffolds/patches. TheE′moduli were also similar to bovine articular cartilage. We have successfully demonstrated that Rylar, a novel bioresorbable radiopaque polymer, when blended with PEGDA can be 3D printed controllably for soft tissue applications such as airway obstructions. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 664–671, 2019.
Examination of inorganic‐based draw solutes and mitigation of their reverse solute flux in osmotic microbial fuel cells
Authors: Wu Simiao , Qian Guangren , He Zhen 
Published: August 2018

AbstractBACKGROUNDOsmotic microbial fuel cells (OsMFCs) integrate microbial fuel cell (MFC) and forward osmosis (FO) and can simultaneously achieve wastewater treatment, electricity generation and water recovery. The selection of appropriate draw solutes (DS) and reduction of reverse solute flux (RSF) are the key challenges for OsMFC operation. This study has examined ten inorganic‐based DS and investigated the effect of electricity generation on the RSF.RESULTSThe OsMFC exhibited stable electricity generation with Na+‐series and K+‐series DS. For NH4+‐series DS, the ammonia‐nitrogen loss percentage, which varied from 12.5 ± 0.4% to 47.7 ± 2.4%, was significant due to the high pH and aeration in the cathode. Inorganic scaling/precipitation was observed with Mg2+‐series and Ca2+‐series DS with DS loss percentage from 13.5 ± 2.8% to 28.0 ± 0.3%. Electricity generation could reduce the specific RSF by 70.3 ± 4.9% and 56.7 ± 13.4% for the Na+ and K+ DS, respectively.CONCLUSIONThe Na+‐series and K+‐series DS was identified as the ideal DS for the OsMFC because of stable electricity generation and water flux and significant RSF reduction. NH4+‐series, Mg2+‐series and Ca2+‐series DS were not appropriate due to significant loss. Bioelectricity generation could reduce both RSF and specific RSF. © 2018 Society of Chemical Industry
Micronutrient productivity: a comprehensive parameter for biofortification in rice (Oryza sativa L.) grain
Authors: Khan Jameel A , Narayana Krupa Kuntanahalli , Holla Sumantha , Shrinivas Sowjanya Makkivalli , Dar Zahoor A , Shashidhar Halagappa Eshwarappa 
Published: August 2018

AbstractBACKGROUNDEnhancing the micronutrient content of staple crops such as rice will improve human nutrition and address the problem of hidden hunger globally. Rice grains consumed after polishing lack adequate amounts of micronutrients. The present study aims to reveal the effects of polishing on micronutrient content and to identify superior genotype(s) to improve yield and micronutrient content after polishing.RESULTSAM65 exhibited the highest zinc content, and AM180 had the highest iron content, even after polishing. There was little or no difference between the genotypes for zinc content in bran, indicating a possible threshold for micronutrient accumulation in the aleurone layer. A comprehensive selection criterion called ‘micronutrient productivity’ was used to select for both yield and micronutrient parameters. AM65 and ARB6 showed high zinc and iron productivity indices. OsZIP4b and OsZIP6c markers showed an association with iron content on an agarose gel. Sequencing of markers revealed that OsYSL15 and OsZIP6c were associated with grain zinc content and OsZIP3b, OsMTP1a, and OsYSL4b with grain iron content. These markers can be used for selecting superior accessions.CONCLUSIONAM65 was loaded with micronutrients and manifested a positive correlation with the grain yield, and it is undoubtedly ‘super elite’. Bran does not drain the grain but rather acts as gateway for micronutrient transportation to the endosperm. Micronutrient productivity is a comprehensive parameter for the biofortification of grain. © 2018 Society of Chemical Industry
Thorough characterization and stability of HP‐β‐cyclodextrin thymol inclusion complexes prepared by microwave technology: A required approach to a successful application in food industry
Authors: Rodríguez‐López María Isabel , Mercader‐Ros María Teresa , López‐Miranda Santiago , Pellicer José A , Pérez‐Garrido Alfonso , Pérez‐Sánchez Horacio , Núñez‐Delicado Estrella , Gabaldón José A 
Published: August 2018

AbstractBACKGROUNDThe aims of the present study were to obtain a stable dry powder formulation of cyclodextrins (CDs) encapsulating thymol, for successful use as an ingredient on an industrial scale, and to characterize the thymol‐CDs complexes using different techniques.RESULTSThymol was successfully solubilized in aqueous solutions and the Kc value increased with the pH of the media until the pH was neutral, giving the highest values (2583 ± 176 L mol−1) for HP‐β‐cyclodextrins (HP‐β‐CDs). The best encapsulation efficiency of thymol in solid complexes was obtained using the microwave (MWI) encapsulation method. The different characterization techniques have demonstrated the affinity of HP‐β‐CDs for thymol molecules, forming stable complexes.CONCLUSIONSThe results support the use of the MWI method in the preparation of solid HP‐β‐CD‐thymol complexes, due to greater encapsulation efficiency and technological and economic advantages for industrial applications. © 2018 Society of Chemical Industry
Impact of steam treatment on shelf‐life stability of a xanthone‐rich green herbal tea (Cyclopia maculata Andrews Kies) – identifying quality changes during storage
Authors: Alexander Lara , de Beer Dalene , Muller Magdalena , van der Rijst Marieta , Joubert Elizabeth 
Published: August 2018

AbstractBACKGROUNDSteam treatment of shredded, fresh C. maculata (honeybush) plant material improves the aroma of this green herbal tea with a slight impact on color and phenolic content, but the effect on storage stability is not known.RESULTSSteam‐treated (60 s before drying) and untreated (control) dried plant material was stored under normal storage conditions in semi‐permeable sachets at 25 °C and 60% relative humidity. Reference samples of treated (steamed) and untreated (control) material were stored at 0 °C in impermeable pouches for maximum retention of quality. The stability of the herbal tea was assessed in terms of sensory profile, phenolic composition and color over a storage period of 6 months. Normal storage conditions resulted in a significant (P < 0.05) decrease in green color, especially in steamed samples. Intensities of fruity and sweet‐associated aroma attributes increased progressively during storage, while the opposite was observed for vegetal and cereal‐like attributes. These changes in the aroma profile were more pronounced in untreated (control) samples. Individual phenolic content remained stable during storage.CONCLUSIONSStorage of 3 to 6 months may result in a more appealing aroma profile and enhanced product quality, despite loss of green color. © 2018 Society of Chemical Industry
Post‐veraison trimming slow down sugar accumulation without modifying phenolic ripening in Sangiovese vines
Authors: Valentini Gabriele , Allegro Gianluca , Pastore Chiara , Colucci Emilia , Filippetti Ilaria 
Published: August 2018

AbstractBACKGROUNDVineyard strategies have recently been developed to combat the effects of global warming on grapevines, which is causing grapes to ripen quickly, excessive sugar accumulation in berries, and high alcohol levels in wines. We evaluate the effectiveness of post‐veraison trimming as a means of slowing down sugar accumulation, without modifying phenolic ripening, in Sangiovese vines grown in highly fertile and well watered soil.RESULTSThe removal of about two‐thirds of the leaf area by shoot trimming after veraison led to a reduction in sugar content without affecting yield. Total and extractable anthocyanins, skin, and seed tannins showed no significant variation at harvest after the treatment during the three‐year trial, while the replenishment of carbohydrates in canes at the end of the trial was negatively affected.CONCLUSIONSThese results indicate that, in highly fertile and well‐watered soil, post‐veraison trimming may represent a powerful tool for decreasing sugar concentration during harvest without affecting yield or total and extractable phenolic compounds. However, the reduction in starch reserves compared to the control serves as a warning about repeated trimming over the years. © 2018 Society of Chemical Industry
Effects of dietary zinc oxide nanoparticles supplementation on growth performance, zinc status, intestinal morphology, microflora population, and immune response in weaned pigs
Authors: Pei Xun , Xiao Zhiping , Liu Lujie , Wang Geng , Tao Wenjing , Wang Minqi , Zou Junbiao , Leng Dongbi 
Published: August 2018

AbstractBACKGROUNDThis study evaluated the effects of dietary zinc oxide nanoparticles (nano‐ZnOs) on growth performance, zinc status, intestinal morphology, microflora population, and immune response in weaned piglets. A total of 150 weaned piglets (9.37 ± 0.48 kg) were randomly allotted to five dietary treatments and fed with a basal diet (control), or the basal diet supplemented with nano‐ZnOs at 150, 300, or 450 mg kg−1, and 3000 mg kg−1 ZnO for 21 days. After a feeding test, six pigs from the control, 450 mg kg−1 nano‐ZnOs and 3000 mg kg−1 ZnO groups were slaughtered.RESULTSCompared with the control, dietary supplements of nano‐ZnOs and ZnO could improve (P < 0.05) average daily weight gain (ADG), average daily feed intake (ADFI), and villus height to crypt depth ratio in the duodenum and jejunum, and decrease (P < 0.05) diarrhea incidence. Zinc retention in the serum, heart, liver, spleen and kidney of pigs supplemented with nano‐ZnOs and ZnO was increased (P < 0.05). Nano‐ZnOs decreased (P < 0.05) the zinc excretion compared with conventional ZnO. Lower Escherichia coli counts in the cecum, colon, and rectum were observed (P < 0.05) in the nano‐ZnOs group compared with the other groups. Compared with the control, ZnO and nano‐ZnOs increased (P < 0.05) the serum concentration of IgA, IL‐6, and TNF‐α, and decreased (P < 0.05) the concentration of IgM.CONCLUSIONThese results indicated that low doses of nano‐ZnOs can have beneficial effects on growth performance, intestinal morphology and microflora, and immunity in weanling pigs, which are similar to the effects of pharmacological dosages of conventional ZnO. Nano‐ZnOs may reduce mineral excretion, which may reduce environmental challenges. © 2018 Society of Chemical Industry
Efficacy of adjunctive photodynamic therapy in the treatment of generalized aggressive periodontitis: A randomized controlled clinical trial
Authors: Borekci Tugce , Meseli Suleyman Emre , Noyan Ulku , Kuru Bahar Eren , Kuru Leyla 
Published: August 2018

ObjectivesGeneralized aggressive periodontitis (GAgP) is a distinct type of periodontal disease characterized by rapid loss of attachment and alveolar bone occurring in young individuals. Photodynamic therapy (PDT) was introduced in periodontology as an adjunctive approach to non‐surgical periodontal treatment (NPT) in periodontitis patients. In this trial, the aim was to evaluate the clinical and microbiological effects of adjunctive PDT to NPT in patients with GAgP.MethodsIn this prospective controlled clinical study, 24 systemically healthy, non‐smoking subjects with GAgP were enrolled. Subjects were randomly assigned into a control group (n = 12) treated with NPT only or to a test group (n = 12) treated with NPT and PDT. Plaque index, sulcus bleeding index (SBI), probing depth (PD), relative attachment level, gingival recession, and tooth mobility were recorded at baseline and on day 63. Microbiological samples were obtained from the sites with PD ≥ 5 mm at both time periods and evaluated for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Treponema denticola via micro‐IDent® test.ResultsClinical and microbial parameters declined significantly in both groups after the treatments (P < 0.01). The comparisons between the groups showed that only the full mouth SBI score of the test group was significantly lower than the control group on day 63 (P < 0.05). Although the reduction in periodontopathogens of the test group was greater than the control group, there was no significant difference between the groups (P > 0.05).ConclusionsWithin the limits of this study, it can be concluded that in the treatment of GAgP, usage of PDT as an adjunct to NPT does not lead to any beneficial effects on the investigated clinical and microbiological parameters except for SBI. Nevertheless, the statistically significant difference for the SBI score demonstrates that PDT may have additional effect on the reduction in gingival bleeding. Lasers Surg. Med. 51:167–175, 2019. © 2018 Wiley Periodicals, Inc.
Do touch interface users feel more engaged? The impact of input device type on online shoppers’ engagement, affect, and purchase decisions
Authors: Chung Sorim , Kramer Thomas , Wong Elaine M. 
Published: August 2018

AbstractOver the past decade, one of the most fundamental changes in computer‐mediated environments has been the evolution in the type of input devices from mouse devices to touch interfaces. In this paper, the authors conduct three experiments to examine the underlying connections between input device types and online shoppers’ decision‐making processes in relation to affect‐driven information processing. The results show that shoppers who use a touch interface (vs. mouse) to view products demonstrate a significantly higher engagement with their shopping experience in a low‐involvement setting. Touch interface users are likely to have greater purchase intentions, as compared to mouse users, and this effect is mediated by positive affect induced by higher engagement. Using a touch interface (vs. mouse) also increases the likelihood that consumers will choose a hedonic over a utilitarian option and make an immediate purchase decision. These findings indicate that using a touch interface increases consumers’ reliance on affect‐driven information processing and has a positive impact on purchase decision processes.
Biomarkers of Individual Foods, and Separation of Diets Using Untargeted LC–MS‐based Plasma Metabolomics in a Randomized Controlled Trial
Authors: Acar Evrim , Gürdeniz Gözde , Khakimov Bekzod , Savorani Francesco , Korndal Sanne Kellebjerg , Larsen Thomas Meinert , Engelsen Søren Balling , Astrup Arne , Dragsted Lars O. 
Published: August 2018

ScopeSelf‐reported dietary intake does not represent an objective unbiased assessment. The effect of the new Nordic diet (NND) versus average Danish diet (ADD) on plasma metabolic profiles is investigated to identify biomarkers of compliance and metabolic effects.Methods and resultsIn a 26‐week controlled dietary intervention study, 146 subjects followed either NND, a predominantly organic diet high in fruit, vegetables, whole grains, and fish, or ADD, a diet higher in imported and processed foods. Fasting plasma samples are analyzed with untargeted ultra‐performance liquid chromatography‐quadruple time‐of‐flight. It is demonstrated that supervised machine learning with feature selection can separate NND and ADD samples with an average test set performance of up to 0.88 area under the curve. The NND plasma metabolome is characterized by diet‐related metabolites, such as pipecolic acid betaine (whole grain), trimethylamine oxide, and prolyl hydroxyproline (both fish intake), while theobromine (chocolate) and proline betaine (citrus) were associated with ADD. Amino acid (i.e., indolelactic acid and hydroxy‐3‐methylbutyrate) and fat metabolism (butyryl carnitine) characterize ADD whereas NND is associated with higher concentrations of polyunsaturated phosphatidylcholines.ConclusionsThe plasma metabolite profiles are predictive of dietary patterns and reflected good compliance while indicating effects of potential health benefit, including changes in fat metabolism and glucose utilization.
Prediction of peripheral nerve stimulation thresholds of MRI gradient coils using coupled electromagnetic and neurodynamic simulations
Authors: Davids Mathias , Guérin Bastien , vom Endt Axel , Schad Lothar R. , Wald Lawrence L. 
Published: August 2018

PurposeAs gradient performance increases, peripheral nerve stimulation (PNS) is becoming a significant constraint for fast MRI. Despite its impact, PNS is not directly included in the coil design process. Instead, the PNS characteristics of a gradient are assessed on healthy subjects after prototype construction. We attempt to develop a tool to inform coil design by predicting the PNS thresholds and activation locations in the human body using electromagnetic field simulations coupled to a neurodynamic model. We validate the approach by comparing simulated and experimentally determined thresholds for 3 gradient coils.MethodsWe first compute the electric field induced by the switching fields within a detailed electromagnetic body model, which includes a detailed atlas of peripheral nerves. We then calculate potential changes along the nerves and evaluate their response using a neurodynamic model. Both a male and female body model are used to study 2 body gradients and 1 head gradient.ResultsThere was good agreement between the average simulated thresholds of the male and female models with the experimental average (normalized root‐mean‐square error: <10% and <5% in most cases). The simulation could also interrogate thresholds above those accessible by the experimental setup and allowed identification of the site of stimulation.ConclusionsOur simulation framework allows accurate prediction of gradient coil PNS thresholds and provides detailed information on location and “next nerve” thresholds that are not available experimentally. As such, we hope that PNS simulations can have a potential role in the design phase of high performance MRI gradient coils.
Impact of the route of clean intermittent catheterization on quality of life in children with lower urinary tract dysfunction
Authors: Alencar Valeria P. , Gomes Cristiano M. , Miranda Eduardo P. , dos Santos Lelis Maria A. , Fera Patrícia , de Bessa Jose , Srougi Miguel , Bruschini Homero 
Published: August 2018

AimsTo compare the impact of the different routes for clean intermittent catheterization on the quality of life of children with lower urinary tract dysfunction.MethodsIn this cross‐sectional study, all children and adolescents under treatment in our clinic from August 2011 to May 2012 who were on CIC for bladder dysfunction were included. To evaluate the technical difficulty and the discomfort associated with the procedure we used a standard visual analog scale. Quality of life was measured using the Pediatric Quality of Life Inventory Version 4.0.ResultsA total of 70 children including 38 (54.3%) boys and 32 (45.7%) girls with a mean age of 11.8 ± 3.6 years (range 5 to 18 years) were evaluated. The mean daily number of catheterizations was 4.2 ± 1.1. CIC was performed through the urethra in 51 (72.9%) subjects and a stoma in 19 (27.1%). A 45 (64.3%) were assisted by a caregiver to perform a catheterization. No differences in both difficulty and discomfort for performing CIC were observed between groups. Children who performed CIC through a stoma had a better quality of life scores for the physical (P = 0.015) and social functioning domains (P = 0.011).ConclusionThe quality of life of children and adolescents performing CIC appears to be affected by the route of catheterization, with a worse performance for those using urethral catheterization.