bluuebunny/crossref_metadata_2025_split huggingface dataset:
INCISION e-learning program as a useful teaching tool to enhance surgeons’ knowledge and skills: An Indonesian multi-center cross-sectional pilot study
Authors: Harzif Achmad Kemal , Rahman M Nurhadi , Mulawardhana Pungky , Shafira Nadia , Anggraeni Tricia Dewi , Sumapraja Kanadi , Ocviyanti Dwiana 
Published: December 2018

Background: Media aids are one of the most important components in the teaching and learning process. This pilot study program was conducted in order to assess the effectiveness of the INCISION e-learning program as teaching media in the surgical teaching and learning process, and its ability to improve surgical skills and knowledge achievement. Methods: One intervention group and one control group were involved in this study. The intervention group used the hysterectomy INCISION e-learning module, while the control group used conventional teaching approaches. The study was conducted with 14 resident surgeons in three universities in Indonesia: Universitas Indonesia, Universitas Airlangga, and Universitas Gajah Mada. The testing components used were a pre-test, post-test questionnaire (a modified Ritzman questionnaire) and direct observation of procedural skills in the operating room (OR). Data were analyzed descriptively using Mann-Whitney and Wilcoxon tests. Results: Using a Mann-Whitney test, we found the differences between the average scores of the intervention group and the control group to be statistically significant (p=0.046). A Wilcoxon test also revealed significant differences (p=0.028). The modified Ritzman questionnaire also revealed that the residents in the intervention group felt more confident in their surgical knowledge (82%), and made more efficient use of their time in the OR (81%). Conclusions: These findings reveal a significant improvement in knowledge and skill achievement in residents that underwent training via the INCISION e-learning module, compared to residents taught via conventional teaching strategies.
Recent advances in understanding inhibitor of apoptosis proteins
Authors: Lalaoui Najoua , Vaux David Lawrence 
Published: December 2018

The inhibitor of apoptosis proteins (IAPs) are a family of proteins that were chiefly known for their ability to inhibit apoptosis by blocking caspase activation or activity. Recent research has shown that cellular IAP1 (cIAP1), cIAP2, and X-linked IAP (XIAP) also regulate signaling by receptors of the innate immune system by ubiquitylating their substrates. These IAPs thereby act at the intersection of pathways leading to cell death and inflammation. Mutation of IAP genes can impair tissue homeostasis and is linked to several human diseases. Small-molecule IAP antagonists have been developed to treat certain malignant, infectious, and inflammatory diseases. Here, we will discuss recent advances in our understanding of the functions of cIAP1, cIAP2, and XIAP; the consequences of their mutation or dysregulation; and the therapeutic potential of IAP antagonist drugs.
Variation in the effectiveness of insecticide treated nets against malaria and outdoor biting by vectors in Kilifi, Kenya
Authors: Kamau Alice , Mwangangi Joseph M. , Rono Martin K. , Mogeni Polycarp , Omedo Irene , Midega Janet , Scott J. Anthony G. , Bejon Philip 
Published: December 2018

Background: Insecticide treated nets (ITNs) protect humans against bites from the Anopheles mosquito vectors that transmit malaria, thereby reducing malaria morbidity and mortality. It has been noted that ITN use leads to a switch from indoor to outdoor feeding among these vectors. It might be expected that outdoor feeding would undermine the effectiveness of ITNs that target indoors vectors, but data are limited. Methods: We linked homestead level geospatial data to clinical surveillance data at a primary healthcare facility in Kilifi County in order to map geographical heterogeneity in ITN effectiveness and observed vector feeding behaviour using landing catches and CDC light traps in six selected areas of varying ITN effectiveness. We quantified the interaction between mosquitoes and humans to evaluate whether outdoor vector biting is a potential explanation for the variation in ITN effectiveness. Results: We observed 37% and 46% visits associated with positive malaria slides among ITN users and non-ITN-users, respectively; ITN use was associated with 32% protection from malaria (crude OR = 0.68, 95% CI: 0.64, 0.73). We obtained modification of ITN effectiveness by geographical area (p=0.016), and identified 6 hotspots using the spatial scan statistic. Majority of mosquitoes were caught outdoor (60%) and were of the An. funestus group (75%). The overall propensity to feed at times when most people were asleep was high; the vast majority of the Anopheles mosquitoes were caught at times when most people are indoors asleep. Estimates for the proportion of human-mosquito contact between the first and last hour when most humans were asleep was consistently high across all locations, ranging from 0.83 to 1.00. Conclusion: Our data do not provide evidence of an epidemiological association between microgeographical variations in ITN effectiveness and variations in the microgeographical distribution of outdoor biting.
What is a balanced knee replacement?
Authors: Walker Lucy C. , Clement Nick D. , Ghosh Kanishka M. , Deehan David J. 
Published: December 2018

For multifactorial reasons an estimated 20% of patients remain unsatisfied after total knee arthroplasty (TKA). Appropriate tension of the soft tissue envelope encompassing the knee is important in total knee arthroplasty and soft tissue imbalance contributes to several of the foremost reasons for revision TKA, including instability, stiffness and aseptic loosening. There is debate in the literature surrounding the optimum way to achieve balancing of a total knee arthroplasty and there is also a lack of an accepted definition of what a balanced knee replacement is. It may be intuitive to use the native knee as a model for balancing; however, there are many difficulties with translating this into a successful prosthesis. One of the foundations of TKA, as described by Insall, was that although the native knee has more weight transmitted through the medial compartment this was to be avoided in a TKA as it would lead to uneven wear and early failure. There is a focus on achieving symmetrical tension and pressure and subsequent ‘balance’ in TKA, but the evidence from cadaveric studies is that the native knee is not symmetrically balanced. As we are currently trying to design an implant that is not based on its anatomical counterpart, is it possible to create a truly balanced prosthesis or to even to define what that balance is? The authors have reviewed the current evidence surrounding TKA balancing and its relationship with the native knee.Cite this article: EFORT Open Rev 2018;3:614-619. DOI: 10.1302/2058-5241.3.180008.
Lean Office and digital transformation: a case study in a services company
Authors: Besser Freitag Alberto Eduardo , Santos Juliana Das Chagas , Reis Augusto Da Cunha 
Published: December 2018

- Highlights: a high percentage of the Western world workforce works in offices; Value Stream Map, a lean tool, allows waste identification in services companies; Lean Management helps companies to prepare for digital transformation; there is scarce scientific literature ondigital transformation and Lean Office.
-Goal: thepurpose of this article is to report the implementation of Lean Office and digital transformation in a services company.
- Design / Methodology / Approach: the research method was a qualitative approach, with literature review followed by a case study, and data collected until September 19, 2018.
- Results: the comparative results between current and future Value Stream Maps showed consistent improvements in terms of performance indicators. The lead time is expected to fall from 101 hours to 64,65 hours under normal conditions, and from 221 hours to 114,65 hours if there is a need to bypass through process # 6.
- Limitations of the investigation: there are limitations in this study.Basically, the time frame until the digitalization of the processes # 1, 2, 3 and 6 have been completed, in order to allow the comparison with the original expectations described in the VSM of the future state.
- Practical implications: it was possible to demonstrate how the implementation of Lean principles, techniques, and tools can bring benefits to an IoT solutions provider.
- Originality / Value: no records were found on Scopus and Web of Science databases for the search sentence "digital transformation" AND "lean Office", representing a gap to be filled with this study.
An empirical wavelet transform based approach for multivariate data processing application to cardiovascular physiological signals
Authors: Singh Omkar , Sunkaria Ramesh Kumar 
Published: December 2018

Abstract

Background
This article proposes an extension of empirical wavelet transform (EWT) algorithm for multivariate signals specifically applied to cardiovascular physiological signals.

Materials and methods
EWT is a newly proposed algorithm for extracting the modes in a signal and is based on the design of an adaptive wavelet filter bank. The proposed algorithm finds an optimum signal in the multivariate data set based on mode estimation strategy and then its corresponding spectra is segmented and utilized for extracting the modes across all the channels of the data set.

Results
The proposed algorithm is able to find the common oscillatory modes within the multivariate data and can be applied for multichannel heterogeneous data analysis having unequal number of samples in different channels. The proposed algorithm was tested on different synthetic multivariate data and a real physiological trivariate data series of electrocardiogram, respiration, and blood pressure to justify its validation.

Conclusions
In this article, the EWT is extended for multivariate signals and it was demonstrated that the component-wise processing of multivariate data leads to the alignment of common oscillating modes across the components.
KOSGEB UYGULAMALI GİRİŞİMCİLİK EĞİTİMİ ADAYLARI ÜZERİNE KASTAMONU İLİNDE BİR ARAŞTIRMA
Authors: Tan Fatma Zehra 
Published: December 2018

Development and the supporting of entrepreneurship which plays a major role in the development of national economies are extremely important in terms of countries. For this purpose, based on the rule of competitive superiority in today's world, state policies encouraging and supporting entrepreneurship have been implemented by the countries. In this study, comparing results of Entrepreneurship test of applicants of Applied Entrepreneurship Trainings that was organized by KOSGEB, firstly, it is mentioned of the concepts of the entrepreneurship that is the key of improvement of the competitiveness between countries and economic development, types of entrepreneurship and finally about supports of KOSGEB and the other institutions for the entrepreneurship. Then, a detailed information is given about KOSGEB’s (that runs programs in order to support the development of entrepreneurship) Applied Entrepreneurship Training. In this context, survey studies have been conducted for the candidate entrepreneurs who want to benefit from the support of entrepreneurship.255 candidate entrepreneurs who apply for Applied Entrepreneurship Trainings that was organized by KOSGEB took place in this study. According to test results; male candidates, candidates having bachelor or master degree and candidates who are between 25 and 35 years old are more successful than others in terms of gender, level of education and age groups, respectively. In addition, since overall success level in tests is high, it is revealed that entrepreneurial potential is high.
YÖNETİCİLERİN LİDERLİK DAVRANIŞLARININ ÇALIŞANLARIN ÖRGÜTSEL BAĞLILIĞI İLE İLİŞKİSİNİN İSTATİSTİKSEL YÖNTEMLERLE ARAŞTIRILMASI
Authors: Durmuş Aydoğan 
Published: December 2018

In this study conducted to research the relationship between leadership behaviors of managers between organizational commitment of employees, a survey has been applied to 155 employees who work in 3 companies in Istanbul province. To measure organizational commitment of employees: "Organizational Commitment Scale" developed by Meyer, Allen ve Smith ; to measure leadership behaviors:" Leadership Behaviors Inventory" of Kent and "Multidimensional Leadership Problems" titled survey forms have been examined and leadership behavior scale which is often used in researches and has been created developing leadership behavior questions based on "Behavioral Repertoire of Leaders" of Goleman. The data collected by the survey were evaluated by entering into SPSS 22 software. As a result of the application; it has been found that, as autocratic, visionary, participating and leadership behaviors of managers strengthen, attendance to corporation and normative commitment of employees increase, as educational and relationship oriented behaviors of managers strengthen, attendance to corporation and normative commitment of employees strengthens. As overall satisfaction level of employees with leadership behavior of managers increases, their attendance and normative commitment to organization increased as well.
İŞ YERİNDE YALNIZLIĞIN TÜKENMİŞLİK ÜZERİNE ETKİSİ
Authors: Akşit Aşık Nuran 
Published: December 2018

This study seeks to explore the relationships between loneliness in the workplace and burnout of the hotel employees’. The population of the study is formed, hotel employees working in the hotel business in Balıkesir city center. Since the population is of accessible size, the full enumerication sample technique was used by accessing the whole population of the study. To collect data for the study, the survey technique was used. The questionnaire work was designed in three parts: the first part contains questions about demographic, the second part contains the loneliness in the workplace scale and also in the third burnout scale. The questionnaire form was administered to the 143 employees. Study results showed that participants had moderate loneliness and burnout high levels and there was a moderate positive correlation between loneliness and burnout. It has been determined that the loneliness in the workplace increase the level of employees’ burnout. Obtained results showed that the loneliness predicted 31,2% of emotional exhaustion, 24,6% depersonalization and 12,6% personal accomplishment and also, social loneliness has the most impact on overall the burnout sub-dimensions.
CSR COMPARISON BETWEEN FAMILY BUSINESSES AND NON-FAMILY BUSINESS
Authors: YAZICI Ömer , MCWILLIAMS Douglas , ERCAN Seydahmet 
Published: December 2018

This paper is designed to explore whether family businesses outperform nonfamily businesses regarding Corporate Social Responsibility (CSR) performance. Upon comparing the CSR performances of 64 top family businesses in the US with CSR performances of the top nonfamily businesses in the US; the results have showed that nonfamily businesses outperform family businesses on CSR. Analysis of four out of five categories of CSR performance resulted in favor of nonfamily businesses and no statistical difference was found in one category. Hence, results show that family businesses are reluctant to corporate social responsibility concern. The result of this study may suggest that family businesses are self-interested; however, some research literature may advise otherwise. Strong agency problems and having family influence in the top management team composition may be shown as the main reason behind this phenomenon. Also results show that among the family businesses, increased family member presence in the top management has a positive effect on CSR performance. For further analysis and future studies, recommendations are made in the conclusion section.
IMPACT OF THE TRAIT- BASED EMOTIONAL INTELLIGENCE ON SELF-ESTEEM FACTOR ACCORDING TO GENDER FACTOR
Authors: BAYRAKTAR Osman , ŞENCAN Hüner , FİDAN Yahya 
Published: December 2018

Goal. In the research, it was tried to determine the effect of the trait-based emotional intelligence scores on self-esteem evaluations, and it was attempted to determine how this effect evolved according to the gender factor. Method. In the study 175 students were partisipte and 171 questionnary were analyzed. To measure emotional intelligence, NHS Emotional Intelligence Scale was used and The Rosenberg Self-Esteem scale was used to measure self-esteem. Correlations, regression analysis, t-test and ANCOVA methods were used to determine the relationship and / or effect between two conceptual structures. Findings. As a result of the research, it was understood that emotional intelligence had no effect on the self-esteem. Because the relations of concepts were not statistically significant (R2 = 0.00). Effect also did not occur at the female and male levels of the variable gender factor. Results. The argument that emotional intelligence, which is the basic hypothesis of the research, is effective on self-esteem scores has not been proved statistically. In the hierarchical regression analysis, which is based on the level of the gender factor, there was no relationship or effect.
Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis
Authors: Nederstigt C , Uitbeijerse B S , Janssen L G M , Corssmit E P M , de Koning E J P , Dekkers O M 
Published: December 2018

Introduction
The association between type 1 diabetes (T1D) and other auto-immune diseases is well known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking.

Methods
We searched PubMed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo and adrenal gland insufficiency. A meta-analysis was performed to estimate pooled prevalence using a random-effects model. Furthermore, random-effects meta-regression analysis was performed to assess the association between prevalence and mean age or diabetes duration.

Results
One hundred eighty articles were eligible including a total of 293 889 type 1 diabetes patients. Hypothyroidism (65 studies) was prevalent in 9.8% (95% CI: 7.5–12.3) of patients. Meta-regression showed that for every 10-year age increase, hypothyroidism prevalence increased 4.6% (95% CI: 2.6–6.6, P < 0.000, 54 studies). Weighted prevalence of celiac disease was 4.5% (95% CI: 4.0–5.5, 87 studies). Gastric autoimmunity was found in 4.3% of patients (95% CI: 1.6–8.2, 8 studies) and vitiligo in 2.4% (95% CI: 1.2–3.9, 14 studies) of patients. The prevalence of adrenal insufficiency was 0.2% (95% CI: 0.0–0.4, 14 studies) and hyperthyroidism was found in 1.3 percent (95% CI: 0.9–1.8, 45 studies) of type 1 diabetes patients. For all analyses, statistical heterogeneity between studies was moderate to high.

Conclusions
The prevalence of antibody-mediated auto-immune disease is high among type 1 diabetes patients. Especially hypothyroidism and celiac disease are frequently found.
Neurochirurgijos ištakos XIX a. pradžios Vilniaus klinikose
Authors: Sakalauskaitė-Juodeikienė Eglė , Kvaščevičius Robertas , Jatužis Dalius 
Published: December 2018

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Įvadas
Iki XIX a. pabaigos neurochirurginės operacijos Europos klinikose buvo atliekamos retai. Neurochirurgijos raida buvo neįmanoma be esminių medicinos atradimų: anestezijos ir antiseptikos, efektyvios hemostazės ir atraumatinės operavimo technikos. Šio darbo tikslas – aptarti neurochirurgijos mokslo ištakas, nustatyti, kokių nervų sistemos chirurgijos operacijų buvo atliekama XIX a. pr. Vilniaus imperatoriškojo universiteto Chirurgijos klinikoje.
Šaltiniai ir metodai
Analizuotos lotynų kalba parašytos Vilniaus imperatoriškojo universiteto (1803–1832 m.) medicinos magistrų disertacijos nervų sistemos chirurgijos tema. Tyrimo metodai: šaltinių analizė, lyginamasis ir analogijos metodai.
Rezultatai
Iš 26 disertacijų, nagrinėjusių nervų ligų klausimus, atrinktos penkios, skirtos nervų sistemos chirurgijai: disertacija apie galvos smegenų sukrėtimą, išorinius galvos sužalojimus, trepanaciją, encefalocelę ir galvos smegenų grybą bei bendrosios miego arterijos perrišimą. Vertinant galvos traumas patyrusius ligonius, įgimtomis CNS ydomis sirgusių kūdikių būklę ar kitą chirurginę nervų sistemos patologiją, stebėtos gyvybinės ligonio funkcijos, vertinta bendrasmegeninė (galvos skausmas, mieguistumas, koma) ir židininė (paralyžiai, konvulsijos, jutimo sutrikimai) neurologinė simptomatika. Vilniaus chirurgai, rinkdamiesi, kurioje galvos pusėje reikėtų dėti trepaną, jei nepastebėta jokių išorinių sužalojimų požymių, tačiau įtariama kraujosruva, ligonio vienpusį paralyžių siejo su tikėtino galvos smegenų pažeidimo, kontralateralinio paralyžiui, lokalizacija. Chirurgijos klinikoje buvo atliekamos mirusių ligonių autopsijos ir, remiantis post mortem radiniais, tvirtinamos klinikinės diagnozės.
Išvados
Neurochirurgijos mokslo ištakos Vilniuje siekia XIX a. pradžią. Vilniaus imperatoriškojo universiteto Chirurgijos klinikoje atlikta pavienių kaukolės trepanacijų, subdurinės hematomos pašalinimo, bendrosios miego arterijos perrišimo ir paviršinių galvos darinių ekscizijos ir ligavimo operacijų.
Riebalinio audinio pasiskirstymo ultragarsinio tyrimo metodikos: sisteminė literatūros apžvalga
Authors: Buckus Bronius , Brimas Gintautas , Brimas Gintautas 
Published: December 2018

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Įvadas / tikslas
Apžvelgti poodinio ir visceralinio riebalinio audinio matavimams naudojamas ultragarsines metodikas ir nustatyti metodiką, tinkamiausią nutukusiems ligoniams.
Metodai
Publikacijų paieška atlikta naudojantis „PubMed“, „Current Contents“ ir „Cochrane Library“ duomenų bazėmis. Į sisteminę apžvalgą įtrauktos visos iki 2017 m. gruodžio 1 d. paskelbtos publikacijos, kuriose ultragarsiniai riebalinio audinio matavimai lyginti su kompiuterinės tomografijos ar magnetinio rezonanso tyrimų duomenimis.
Rezultatai
Į sisteminę apžvalgą įtraukta 17 studijų, kuriose nagrinėjami ultragarsinių riebalinio audinio matavimų duomenys. Šiose studijose ištirti 1 085 ligoniai. Studijose, lyginančiose įvairių autorių ultragarsinio tyrimo ir kompiuterinės tomografijos ar magnetinio rezonanso tyrimo metu išmatuoto riebalinio audinio pasiskirstymą, nustatytas visceralinio riebalinio audinio rodiklių koreliacijos koeficientas siekė nuo 0,63 iki 0,94, poodinio riebalinio audinio rodiklių – nuo 0,33 iki 0,96. Šešiose studijose išskirtos nutukusių ar morbidiniu nutukimu sergančių asmenų grupės (KMI ≥30 kg/m2). Tiriant nutukusius asmenis, geriausių rezultatų pasiekta naudojant modifikuotą R. P. Stolk’o metodiką. Visceralinio riebalinio audinio rodiklių koreliacijos koeficientas tarp kompiuterinės tomografijos ir ultragarso siekė 0,823, poodinio riebalinio audinio – 0,745, o, tiriant morbidiniu nutukimu sergančius ligonius, tyrimų patikimumo rodikliai siekė 0,94.
Išvados
Ultragarsinis tyrimas yra pigus, neinvazyvus, prieinamas ir kartotinis tyrimo metodas. Šį metodą taikant riebalinio audinio pasiskirstymui matuoti, galima atlikti didelės apimties populiacijos tyrimus. Nutukimu sergančių ligonių riebalinio audinio pasiskirstymui matuoti rekomenduojama ultragarsinė, modifikuota R. P. Stolk’o metodika.