bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of non‐compliant balloon postdilatation on magnesium‐based bioresorbable vascular scaffolds
Authors: Blachutzik Florian , Achenbach Stephan , Tröbs Monique , Marwan Mohamed , Weissner Melissa , Nef Holger , Schlundt Christian 
Published: September 2018

AbstractBackgroundOptimal implantation results of bioresorbable scaffolds (BRS) are typically assumed to require postdilatation with non‐compliant (NC) balloons to achieve full scaffold apposition and minimize event rates. We systematically evaluated the mechanical effect of NC balloon postdilatation on magnesium‐based BRS (Magmaris®, Biotronik AG, Bülach, Switzerland) in vivo.MethodsIn 35 patients, 40 Magmaris® BRS were implanted to treat 37 de novo coronary artery stenoses. A systematic implantation protocol was followed. After appropriately sized NC balloon predilatation (1:1:1 vessel:balloon:scaffold ratio), Magmaris® BRS were implanted with a pressure of 10 atm, followed by NC balloon postdilatation at nominal BRS size (standardized at 16 atm). OCT was performed before and after postdilatation and OCT images were analyzed at a spacing of 0.2 mm to measure BRS dimensions and determine apposition as well as to detect strut fractures.ResultsPCI with Magmaris® BRS (mean diameter: 3.21 ± 0.32 mm; mean length: 20 ± 4 mm) was successful in all cases, in one case a non‐flow‐limiting distal edge dissection occurred after implantation and before postdilatation. NC balloon postdilatation led to significantly larger mean scaffold diameter (3.21 ± 0.32 mm vs. 2.80 ± 0.39 mm, P < 0.001), abluminal scaffold area (7.92 ± 1.43 mm2 vs. 6.72 ± 1.28 mm2, P < 0.001) and lumen area (7.58 ± 1.1 mm2 vs. 6.83 ± 1.12 mm2, P < 0.001). Incomplete scaffold apposition area was significantly lower if postdilatation was performed (0.01 ± 0.04 mm2 vs. 0.17 ± 0.11 mm2, P < 0.001). Strut fractures could neither be observed before nor after postdilatation.ConclusionNC balloon postdilatation of Magmaris® BRS is required to achieve optimal expansion. It significantly reduces malapposition and can safely be performed without relevant rates of strut fracture.
Retrograde percutaneous coronary intervention for acute myocardial infarction following blunt chest trauma
Authors: Okumura Hiroyuki , Hayashi Hiroki , Harada Masaki , Mikuri Mikiko 
Published: September 2018

AbstractA 78‐year‐old man was admitted to the emergency department because of chest pain following blunt chest trauma. Chest X‐ray revealed multiple rib fractures. However, electrocardiogram showed ST elevation in inferior leads suggesting acute myocardial infarction (AMI). Emergency coronary angiography revealed normal left coronary artery and occluded proximal right coronary artery. Thus, percutaneous coronary intervention (PCI) was performed immediately. Antegrade PCI was unsuccessful due to a very large false lumen, which was caused by a blunt trauma. However, retrograde guidewire (GW) manipulation was relatively easy to negotiate the occluded lesion. After GW externalization, we deployed two drug eluting stents for this lesion. To our knowledge, this is the first case of retrograde PCI that led to a successful reperfusion therapy for AMI following blunt chest trauma.
Validation and refinement of the catheterization RISk score for pediatrics (CRISP score): An analysis from the congenital cardiac interventional study consortium
Authors: Hill Kevin D. , Du Wei , Fleming Gregory A. , Forbes Thomas J. , Nykanen David G. , Reeves Jaxk , Du Yan , Kobayashi Daisuke 
Published: September 2018

AbstractObjectivesTo externally validate the CRISP score, and determine if refinements might improve clinical utility.BackgroundThe CRISP score estimates risk of serious adverse events (SAEs) for pediatric catheterization.MethodsPediatric (age < 18) procedures reported to the Congenital Cardiovascular Interventional Study Consortium registry from 05/08 to 09/17 (n = 29,830, 27 centers) were divided into a development dataset of 14,784 earlier procedures, and a validation dataset of 15,046 more recent procedures. The development dataset was used to refit the original CRISP model, and to develop a revised(r) CRISP score, consisting of entirely pre‐procedurally collected data. The validation dataset was then used to compare model fit and risk prediction between CRISP, rCRISP and two existing risk scores using Akaike's (AIC), Schwarz's (BIC) Bayes Information Criteria, −log Likelihood (N2LL), area under the receiver operator curve and chi‐square goodness‐of‐fit statistic (across 5 risk categories).ResultsOverall 4.31% of patients experienced at least one SAE with frequency increasing from 1.08% in CRISP category 1 to 27.34% in category 5. Both CRISP and rCRISP (entirely pre‐procedural) predicted risk of SAEs well, with observed to predicted ratios ranging from 0.71 to 1.18 across the 5 risk categories. Compared to the original CRISP score, rCRISP demonstrated less optimal model fit (higher AIC, BIC, and N2LL) but similar risk prediction (C‐statistic = 0.71 vs. 0.70; chi‐squared statistic = 6.77 vs. 6.85).ConclusionThe CRISP score accurately predicts procedural risk. With minor modifications, the revised version (rCRISP) performed well with arguably greater clinical utility as an entirely preprocedural risk model.
A Heterogeneous Hydrogen‐Evolution Catalyst Based on a Mesoporous Organosilica with a Diiron Catalytic Center Modelling [FeFe]‐Hydrogenase
Authors: Himiyama Tomoki , Waki Minoru , Esquivel Dolores , Onoda Akira , Hayashi Takashi , Van Der Voort Pascal , Inagaki Shinji 
Published: September 2018

AbstractA diiron [FeFe]‐hydrogenase model complex tethered with a maleimide group, FeFe1, was covalently grafted on the pore surface of a periodic mesoporous organosilica with thiol groups (SH‐PMO) to form an efficient heterogeneous hydrogen (H2)‐evolution catalyst FeFe1@PMO. The coordination structure of the FeFe1 complex and the ordered pore structure were almost completely preserved even after immobilization of FeFe1 on SH‐PMO. The FeFe1@PMO promoted photocatalysis for H2 evolution in water containing a photosensitizer [Ru(bpy)3]2+, with a turnover number (TON) of 310 over 120 min. The TON was greater than those of an analogous homogeneous FeFe1 catalyst (TON=180) and conventional diiron complexes immobilized on solid supports (TON=6–18). The increased TON for FeFe1@PMO compared to the homogeneous FeFe1 was attributed to the improvement in the stability of the FeFe1 complex by immobilization on the pore surface of SH‐PMO. A [Ru(bpy)3]2+ photosensitizer tethered with a maleimide (Ru1) was prepared and co‐immobilized on FeFe1@PMO to form an all‐solid‐state photocatalyst FeFe1‐Ru1@PMO. FeFe1‐Ru1@PMO evolved H2 without the additional [Ru(bpy)3]2+ photosensitizer, suggesting efficient photoinduced electron transfer from the immobilized Ru1 to the immobilized FeFe1.
Homogeneously Catalyzed 1,3‐Diene Functionalization – A Success Story from Laboratory to Miniplant Scale
Authors: Herrmann Norman , Vogelsang Dennis , Behr Arno , Seidensticker Thomas 
Published: September 2018

AbstractFor many years, the efficient use of resources has been a major and permanent challenge for the chemical industry. The implementation of alternative resources such as renewables and carbon dioxide has been a subject of considerable discussion, but also the more efficient use of long known bulk chemicals is of great interest. Among them, 1,3‐dienes such as 1,3‐butadiene from the C4 cut of the naphtha cracker as well as isoprene, piperylene and cyclopentadiene from the corresponding C5 section are important substrates. These dienes are presently employed in various markets, with the greatest importance being in the production of polymers and copolymers. However, homogeneous transition metal catalysis has proven to be a versatile tool to functionalize these important 1,3‐dienes to low molecular weight fine chemicals by introducing, for example, nitrogen, oxygen or silicon. Hence, an upgraded use of the corresponding products as agrochemicals, pharmaceuticals, fragrances or special detergents is close at hand. The main approaches in the topic of homogeneous functionalization reactions of the industrially relevant 1,3‐dienes will be summarized and discussed within the present article. Besides that, novel applications including renewable 1,3‐dienes, for example β‐myrcene and β‐farnesene, as well as the application of CO2 in telomerization, will be critically discussed.
Cognitive behaviour therapy for distress in people with inflammatory bowel disease: A benchmarking study
Authors: Jordan Cheryl , Hayee Bu'Hussain , Chalder Trudie 
Published: September 2018

AbstractObjectiveAnxiety and depression are common in inflammatory bowel disease (IBD) and have been linked to clinical recurrence. Previous randomized controlled trials (RCT's) have found no evidence that psychological interventions enhance outcomes for people with IBD but have recruited patients without distress. This study investigates the clinical benefits of a nonrandomized uncontrolled study of clinic based cognitive behaviour therapy (CBT) for people with IBD who had moderate–severe levels of anxiety or low mood and compares the results with a previous RCT of CBT in this population.MethodAssessments were completed at baseline and end of treatment and included measures of low mood, generalized anxiety, quality of life (QOL), and symptomatic disease activity. The patient health questionnaire and generalized anxiety disorder 7 measures were the primary outcomes. Results in the form of a standardized effect size of treatment were compared with a previous RCT to consider if CBT had greater benefits for those with distress.ResultsThirty patients were deemed appropriate for CBT, and 28 accepted treatment. The results from this clinic based CBT intervention suggest statistically significant reductions in symptoms of anxiety (<0.001), low mood (<0.001), and disease activity (p < 0.01) and increases in QOL (p < 0.001). The uncontrolled effect sizes were large and superior to those found in published RCTs.ConclusionThis nonrandomized uncontrolled trial of a clinic‐based CBT intervention suggests that CBT may have benefits for those with moderate–severe disturbances to mood and that effect sizes can be improved by targeting those with distress. RCTs are required to establish efficacy.
Single‐Site Ruthenium Pincer Complex Knitted into Porous Organic Polymers for Dehydrogenation of Formic Acid
Authors: Wang Xinbo , Ling Eleanor Ang Pei , Guan Chao , Zhang Qinggang , Wu Wenting , Liu Pengxin , Zheng Nanfeng , Zhang Daliang , Lopatin Sergei , Lai Zhiping , Huang Kuo‐Wei 
Published: September 2018

AbstractOwing to its capacity for reversible hydrogen storage, formic acid (FA) holds great promise as an alternative energy carrier to conventional fossil fuel systems. Whereas the decomposition of FA to hydrogen (H2) and carbon dioxide (CO2) through homogeneous catalysis is well established, the selective and efficient dehydrogenation of FA by a robust heterogeneous catalyst remains a challenge. A new heterogeneous ruthenium pincer framework with single‐atomic sites was prepared in one step by the direct knitting of a phosphorus–nitrogen PN3P‐pincer ruthenium complex in a porous organic polymer. The heterogeneous ruthenium complex efficiently dehydrogenates formic acid in both organic and aqueous media with remarkably enhanced stability. Notably, no detectable CO was generated and a turnover number (TON) of 145 300 was attained in a continuous experiment with no significant decline in catalytic activity (in sharp contrast, a total TON of only 5600 was obtained with the homogeneous analog under the same conditions). The single‐atomic sites in the porous framework combined the desirable attributes of high reactivity and selectivity of a homogeneous catalyst with the significantly enhanced catalyst stability and reusability benefits of heterogeneous catalysis.
A voltage tunable CMOS differential active resistor and its application
Authors: Maundy Brent J. , Elwakil Ahmed S. , Zito Domenico 
Published: September 2018

SummaryWe propose a novel CMOS differential voltage‐controlled equivalent active resistor based on a modified common‐source cross‐coupled pair. The equivalent resistance exhibited by the circuit can be tuned to be either positive or negative through the tail current, which is controlled by a bias voltage. The complete cell comprises four transistors, two resistors in addition to the bias voltage, and tail current source. Application to the design of oscillators is demonstrated by theoretical analysis, circuit simulations, and verified experimentally through measurements on prototypes implemented using discrete transistors.
Effects of a large flood on woody vegetation along the regulated Missouri River, USA
Authors: Boever Christopher J. , Dixon Mark D. , Johnson W. Carter , Scott Michael L. , Malloy Terrence P. 
Published: September 2018

AbstractIn 2011, a large, long‐duration flood occurred on the regulated Missouri River following six decades without flooding. This study evaluated the effects of the flood on riparian forest structure and composition. In 2012, 168 forest sites sampled in 2006–2009 were resampled on five floodplain segments between Montana and Missouri, with 80 sampled again in 2013–2014. Changes in riparian forest area over 2006–2012, by age class and segment, were assessed using aerial imagery and GIS. Repeated‐measures analysis of variance was used to examine (a) the initial effects of the flood (preflood to 2012) on tree and shrub stem densities, (b) postflood (2012–2014) changes in stem density, and (c) species‐level responses for cottonwood (Populus deltoides), eastern red cedar (Juniperus virginiana), and Russian olive (Elaeagnus angustifolia). Across the study area, forest area declined 6–38% among age classes, with the greatest declines in the youngest classes. Tree density declined 19–49% across segments from preflood to 2012 but did not change significantly from 2012 to 2014. Shrub density declined 52–89% across segments from preflood to 2012, with 73–78% declines in the two youngest age classes, but increased by 42% from 2012 to 2014. Cottonwood and Russian olive, but not red cedar, showed partial recovery in the shrub/sapling layer, increasing from 2012 to 2014. Although flooding is important for floodplain forest health, the 2011 flood had mixed effects, with significant mortality of native floodplain trees and shrubs and only limited cottonwood recruitment. The initial decline in invasive species (Russian olive and red cedar), however, suggests that flooding may be an effective management tool.
NBCe1 mediates the regulation of the NADH/NAD+redox state in cortical astrocytes by neuronal signals
Authors: Köhler Susanne , Winkler Ulrike , Sicker Marit , Hirrlinger Johannes 
Published: September 2018

AbstractAstrocytes are a glial cell type, which is indispensable for brain energy metabolism. Within cells, the NADH/NAD+redox state is a crucial node in metabolism connecting catabolic pathways to oxidative phosphorylation and ATP production in mitochondria. To characterize the dynamics of the intracellular NADH/NAD+redox state in cortical astrocytes Peredox, a genetically encoded sensor for the NADH/NAD+redox state, was expressed in cultured cortical astrocytes as well as in cortical astrocytes in acutely isolated brain slices. Calibration of the sensor in cultured astrocytes revealed a mean basal cytosolic NADH/NAD+redox ratio of about 0.01; however, with a broad distribution and heterogeneity in the cell population, which was mirrored by a heterogeneous basal cellular concentration of lactate. Inhibition of glucose uptake decreased the NADH/NAD+redox state while inhibition of lactate dehydrogenase or of lactate release resulted in an increase in the NADH/NAD+redox ratio. Furthermore, the NADH/NAD+redox state was regulated by the extracellular concentration of K+, and application of the neurotransmitters ATP or glutamate increased the NADH/NAD+redox state dependent on purinergic receptors and glutamate uptake, respectively. This regulation by K+, ATP, and glutamate involved NBCe1 mediated sodium‐bicarbonate transport. These results demonstrate that the NADH/NAD+redox state in astrocytes is a metabolic node regulated by neuronal signals reflecting physiological activity, most likely contributing to adjust astrocytic metabolism to energy demand of the brain.
1,2‐Silyl migration in 1‐halonaphthalenes catalyzed by I2
Authors: Shimizu Tomomi , Morisako Shogo , Yamamoto Yohsuke , Kawachi Atsushi 
Published: September 2018

Abstract1‐Halo‐8‐hydrosilylnaphthalenes undergo 1,2‐silyl migration to form 1‐halo‐7‐silylnaphthalenes. The influence of the substituents on the silicon atom, the solvent effect, and the D‐labeling experiments are investigated. The migration process may include four steps: (a) generation of acid (HI) by the reaction of the hydrosilane with I2, (b) protonation of the naphthalene ring, (c) silyl group migration in the protonated intermediate, and (d) deprotonation of the naphthalene ring.
Ergonomic design of a railway traffic control room: A Serbian experience
Authors: Grozdanović Miroljub , Bijelić Bojan 
Published: September 2018

AbstractThe aim of the research presented in this paper is to perform an ergonomic evaluation of compatibility between control desk, display panel, and their control devices with operators’ capabilities in the process of railway traffic control. This paper covers the application of ergonomic criteria for designing the control room and its main elements, functional characteristics of operators, and the influence of illumination on operator’s work efficiency. The paper also introduces methodologies for anthropometric and kinesiological analysis of operators, ergonomic analysis of control desk and display panel, and analysis of illumination in the Railway Traffic Control Room in Nis, Serbia. The research also includes basic statistical parameters for body measures of operators, configuration, and dimension of control desk as a unit, ergonomic analysis of control desk buttons, ergonomic analysis of display panel and its elements, parameters for illumination level of control room, control desk and display panel, and uniformity of illumination and brightness. To establish a link between these research and cognitive demands, methods of cognitive analysis of control and management activities in control room and decision making in abnormal situation by using an operator’s stress model are presented. The importance of this approach is that ergonomic assessment of current condition will determine the inadequate design and the ergonomic approach to be used in the implementation of the analysed control room. The results given in this paper enable the beginning of reconstruction and design of new elements in the control room, which will lead to abettor optimized control of railway traffic.
An unsafe behaviour formation mechanism based on risk perception
Authors: Huang Lang , Wu Chao , Wang Bing , Ouyang Qiumei , Lin Huanhuan 
Published: September 2018

AbstractIt is commonly acknowledged that human behaviour is implicated in most safety problems. However, research on the formation mechanism of unsafe behaviour remains incomplete. Risk perception is one of the fundamental issues in risk research, and individual risk perception can be identified as a critical antecedent of human behaviour. This study attempts to construct and test a theoretical model to reveal the formation mechanism of unsafe behaviour based on risk perception. First, to lay a solid foundation for the developed new mechanism, several key concepts about risk perception and unsafe behaviour were explained. Second, the formation mechanism of biases in individual risk perception was developed based on psychological distance theory, and the biases in risk perception were subsequently classified. Lastly, an unsafe behaviour formation mechanism was put forward based on risk perception as an explanatory variable. This study is novel in that it uses psychological distance to explore the formation of biases in individual risk perception. Further, the presented work provides a new approach to understanding and explaining the formation mechanism of human unsafe behaviour.
A statistical region selection and randomized volumetric features selection framework for early detection of Alzheimer's disease
Authors: Mishra Shiwangi , Beheshti Iman , Khanna Pritee ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: September 2018

AbstractIdentification of dominant imaging biomarkers is important for early detection of Alzheimer's disease (AD) and to improve diagnostic accuracy. This work proposes a novel automatic computer aided diagnosis (CAD) system working on region selection framework. Voxel based morphometry and tissue segmentation is performed to get gray matter (GM) images. These pre‐processed images are anatomized to get 116 regions of brain using a standard automated anatomical labeling atlas. The proposed region selection algorithm identifies the most relevant brain regions out of 116 regions to discriminate AD and healthy control (HC) subjects. Volumetric features (standard deviation, skewness, kurtosis, energy, and shannon entropy) are extracted and random feature selection is performed to get the most discriminating regions to classify AD from HC. Supervised classification algorithms are used to explore and validate the proposed methodology. Experimental results indicate that the performance of the proposed system competes well with the state‐of‐the‐art techniques.
CSF‐1 in Osteocytes Inhibits Nox4‐mediated Oxidative Stress and Promotes Normal Bone Homeostasis
Authors: Werner Sherry L , Sharma Ramaswamy , Woodruff Kathleen , Horn Diane , Harris Stephen E , Gorin Yves , Lee Doug‐Yoon , Hua Rui , Gu Sumin , Fajardo Roberto J , Habib Samy L , Jiang Jean X 
Published: September 2018

AbstractCSF‐1 is a key factor in regulating bone remodeling; osteocytes express CSF‐1 and its receptor. Viable osteocytes are essential for bone remodeling through cell–cell contact and secretion of factors that regulate osteoblasts and osteoclasts. Increased oxidative stress contributes to osteocyte death and correlates with bone loss during aging. The NADPH oxidase Nox4 is a major source of ROS in bone. CSF‐1 decreases Nox4, suggesting that CSF‐1 protects against oxidative stress. Here, we show that osteocyte apoptosis previously reported in our global CSF‐1KO mice is associated with increased Nox4, as well as 4‐HNE expression in osteocytes. Osteocytes isolated from CSF‐1KO mice were less viable and showed increased intracellular ROS, elevated NADPH oxidase activity/Nox4 protein, activation of mTOR/S6K, and downstream apoptosis signals compared with WT osteocytes. Nox4 expression was also increased in CSF‐1KO osteocytes and colocalized with MitoTracker Red in mitochondria. Notably, CSF‐1 inhibited Nox4 expression and apoptosis cascade signals. In additional studies, shNox4 decreased these signals in CSF‐1KO osteocytes, whereas overexpression of Nox4 in WT osteocytes activated the apoptosis pathway. To determine the role of CSF‐1 in osteocytes, DMP1Cre‐CSF‐1cKO (CSF‐1cKO) mice that lack CSF‐1 in osteocytes/late osteoblasts were developed. Osteocyte defects in CSF‐1cKO mice overlapped with those in CSF‐1KO mice, including increased apoptosis, Nox4, and 4‐HNE‐expressing osteocytes. CSF‐1cKO mice showed unbalanced cancellous bone remodeling with decreased bone formation and resorption. Continued exposure to high Nox4/ROS levels may further compromise bone formation and predispose to bone loss and skeletal fragility. Taken together, our findings suggest a novel link between CSF‐1, Nox4‐derived ROS, and osteocyte survival/function that is crucial for osteocyte‐mediated bone remodeling. Results reveal new mechanisms by which CSF‐1/oxidative stress regulate osteocyte homeostasis, which may lead to therapeutic strategies to improve skeletal health in aging. © 2018 American Society for Bone and Mineral Research