bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shifts in national entrepreneurial culture: The promise of linguistic cultural artifacts and machine learning analysis
Authors: Kyprianou Christina , Vedula Siddharth , Pu Wenxi , Fitza Markus 
Published: November 2024

AbstractResearch SummaryWe develop a dynamic view of national entrepreneurial culture by examining the linguistic evolution of media‐produced cultural artifacts—entrepreneurship‐related newspaper articles. Applying machine learning to 690,088 articles from 103 newspapers across the United States between 1996 and 2016, we identify a growing positivity bias toward entrepreneurship at the national level evidenced by rising emotional tone and declining analytical thinking. This bias varies by topic, with “entrepreneurial aspirations and journeys” driving the trend. Our analyses also suggest this bias may encourage the creation of new ventures but limit venture growth potential. We highlight theoretical and methodological contributions to research on national entrepreneurial culture and identify promising avenues for future research.Managerial SummaryWe examine how a country's cultural attitudes toward entrepreneurship change over time by studying relevant newspaper articles. We also consider if any changes in such attitudes may have implications for the quantity and quality of a country's new ventures. After analyzing 690,088 articles from 103 newspapers across the United States between 1996 and 2016, we find a growing positivity bias toward entrepreneurship evidenced by increasing rates of positive tone and decreasing rates of analytical thinking. This bias is largest when media articles discuss entrepreneurial aspirations and journeys. Our analyses also suggest this bias may facilitate the creation of new ventures but limit their growth potential. These findings have implications for understanding and measuring national entrepreneurial culture, and create opportunities for future research.
A Bayesian Approach to Modeling Variance of Intensive Longitudinal Biomarker Data as a Predictor of Health Outcomes
Authors: Yu Mingyan , Wu Zhenke , Hicken Margaret , Elliott Michael R. 
Published: November 2024

ABSTRACTIntensive longitudinal biomarker data are increasingly common in scientific studies that seek temporally granular understanding of the role of behavioral and physiological factors in relation to outcomes of interest. Intensive longitudinal biomarker data, such as those obtained from wearable devices, are often obtained at a high frequency typically resulting in several hundred to thousand observations per individual measured over minutes, hours, or days. Often in longitudinal studies, the primary focus is on relating the means of biomarker trajectories to an outcome, and the variances are treated as nuisance parameters, although they may also be informative for the outcomes. In this paper, we propose a Bayesian hierarchical model to jointly model a cross‐sectional outcome and the intensive longitudinal biomarkers. To model the variability of biomarkers and deal with the high intensity of data, we develop subject‐level cubic B‐splines and allow the sharing of information across individuals for both the residual variability and the random effects variability. Then different levels of variability are extracted and incorporated into an outcome submodel for inferential and predictive purposes. We demonstrate the utility of the proposed model via an application involving bio‐monitoring of hertz‐level heart rate information from a study on social stress.
Neurobiological and Anti‐Inflammatory Effects of a Deep Diaphragmatic Breathing Technique Based on Neofunctional Psychotherapy: A Pilot RCT
Authors: Maniaci Giuseppe , Daino Marco , Iapichino Maria , Giammanco Alessandra , Taormina Calogero , Bonura Giuseppina , Sardella Zaira , Carolla Giuseppe , Cammareri Patrizia , Sberna Emanuele , Clesi Maria Francesca , Ferraro Laura , Gambino Caterina Maria , Ciaccio Marcello , Rispoli Luciano , La Cascia Caterina , La Barbera Daniele , Quattrone Diego 
Published: November 2024

ABSTRACTWe examined the feasibility of using the neofunctional deep breathing (NDB) technique to reduce the allostatic load following the Trier Social Stress Test (TSST). Forty‐four healthy subjects were randomised into experimental and control groups. Following the TSST procedure, participants underwent either a single session of NDB or an attention control intervention. The Procomp Infinity Biofeedback system measured breath per minute (BPM), respiratory amplitude, HRV linear domains, skin conductance, and trapezius muscle electromyographic activity. Cortisol and cytokine salivary concentrations, perceived stress, and anxiety levels were also assessed. These parameters were combined into an allostatic load index (ALI) to measure the intervention's effect. This pilot RCT demonstrated the feasibility of the study design and practicality of the intervention. The NDB group showed reduced ALI, increased respiratory abdominal amplitude, decreased BPM, increased HRV indicating parasympathetic activation, and decreased cortisol and inflammatory cytokines. This study highlighted the feasibility of testing the NDB technique in reducing allostatic load through a neurobiological and anti‐inflammatory response after exposure to psychosocial stress. This protocol can represent a non‐invasive therapeutic adjutant in disorders related to a dysregulation of the HPA axis or to an inflammatory state.Trial Registration: NCT04102813
A Multifunctional Na2Se/Zn‐Mn Skeleton Enables Processable and Highly Reversible Sodium Metal Anode
Authors: Aman Samia , Iqbal Sikandar , Chishti Aadil Nabi , Ali Moazzam , Ali Muhammad , Hussain Hamid , Huang Huiqin , Lin Yechao , Yousaf Muhammad , Jiang Yinzhu 
Published: November 2024

AbstractThe recent high‐energy density sodium (Na) metal batteries (SMBs) are restricted by their processability, lifetime, and safety. These issues can be addressed by controlling the reactions at the Na metal by modifying the Na metal anode (SMA) with the sodiophilic hosts. Herein, a multifunctional Na2Se/Zn‐Mn skeleton is introduced for SMA and fabricate a processable Na@Na2Se/Zn‐Mn composite using repeated cold rolling/folding approach through the spontaneous reaction between Na metal and ZnMnSe alloy. This unique intermetallic composite has Zn and Mn metal sites for uniform deposition of Na, while Na2Se generates a stable SEI for rapid Na+ ion transport. It offers outstanding sodiophilicity, high processability, excellent mechanical strength, and high ionic conductivity due to the synergistic effect of multi‐component, enabling stable Na plating/stripping at high current densities and areal capacities. An optimized Na2Se/Zn‐Mn skeleton enables Na||Na symmetric cells to attain a high critical current density of 5.0 mA cm−2 at 5.0 mAh cm−2 with an extended lifespan of 9000 h at 1.0 mA cm−2 at 1.0 mAh cm−2. Remarkably, when configured into a full cell with a Na3V2(PO4)3 cathode, the SMB displays an extended lifespan of 2000 cycles at 10 C and an impressive high‐rate capacity of ≈61.6 mAh g−¹ at 30 C.
Interfacing Complex Coacervates with Natural Cells
Authors: Meng He , Ji Yanglimin , Qiao Yan 
Published: November 2024

AbstractCoacervates have been investigated as protocells or synthetic cells, as well as subcellular compartments for the creation of new materials, thus bridging the gap between living and non‐living systems in materials science, synthetic biology, and bioengineering. Given the design flexibility and simplicity of coacervates, along with the functionality and complexity of natural cells, the interfacing of complex coacervates with natural cells is considered significant for various biotechnological and biomedical applications. In this review, the fundamental mechanisms and underlying theories of coacervate systems are introduced. Recent efforts to interface coacervates with natural cells are summarized in three key scenarios: (i) the integration of coacervates with natural cell components for the living material assembly into protocells; (ii) communication between therapeutic synthetic cells and natural cells for drug delivery and cell repair; and (iii) the formation of intracellular condensates for metabolic regulation, followed by the regulation of their phase transitions for pathological elucidation. Finally, the potential of coacervate‐natural cell interfaces is discussed in the context of developing living/synthetic cell constructs, creating precise disease therapy strategies, and advancing programmable metabolic engineering networks.
Genome‐wide association of an organic naked barley diversity panel identified quantitative trait loci for disease resistance
Authors: Kunze Karl H. , Meints Brigid , Massman Chris , Gutiérrez Lucia , Hayes Patrick M. , Smith Kevin P. , Bergstrom Gary C. , Sorrells Mark E. 
Published: November 2024

AbstractFoliar fungal diseases are a major limitation in organic naked barley (Hordeum vulgare L.) production. The lack of conventional fungicides in organic systems increases reliance on genetic resistance. We evaluated the severity of barley stripe rust (Puccinia striiformis f. sp. hordei Westend), leaf rust (Puccina hordei sp. hordei), spot blotch (Cochliobolus sativus, anamorph Bipolaris sorokiniana (S. Ito & Kurib.) Drechsler ex Dastur), and scald (Rhynchosporium commune Zaffarano, McDonald and Linde sp. nov) on a naked barley diversity panel of 350 genotypes grown in 13 environments to identify quantitative trait loci associated with disease resistance. Genome‐wide association analyses across and within environments found 10 marker trait associations for barley stripe rust, four marker trait associations for leaf rust, one marker trait association for scald, and five marker trait associations for spot blotch. Structure analysis identified six Ward groups based on genotypic diversity. Resistance to susceptible allele ratios were high for stripe rust and spot blotch, moderate for leaf rust, and low for scald. Combined phenotypic analysis values for each disease overlayed by a principal component analysis found distinct resistance and susceptibility patterns for barley stripe rust and scald. Most significant marker trait associations were previously identified in the literature, providing confirmation and potential new sources of disease resistance for genetic improvement of naked barley germplasm.
Prior metabolic and bariatric surgery is an independent determinant of severity of decompensation in alcohol‐associated liver disease
Authors: Onghena Louis , van Nieuwenhove Yves , Van Vlierberghe Hans , Devisscher Lindsey , Raevens Sarah , Verhelst Xavier , Lefere Sander , Geerts Anja 
Published: November 2024

AbstractBackgroundPatients with a history of metabolic and bariatric surgery (MBS) are susceptible to developing alcohol use disorder, potentially resulting in end‐stage liver disease, with a paucity of data on the evolution of cirrhosis.AimsOur aim was to describe the demographics and mortality in hospitalizations over time in individuals diagnosed with cirrhosis due to alcohol‐associated liver disease (ALD) in relation to prior MBS.MethodsWe included patients hospitalized at the Ghent University Hospital between 1/1/2010 and 01/09/2023 with cirrhosis due to ALD. Data were retrieved retrospectively from all hospitalizations.Results46/275 (16.7%) of individuals with cirrhosis admitted with ALD had a history of MBS; they were predominantly female (76.1%), in contrast to the non‐MBS population (29.7%) (p < 0.0001) and were significantly younger at the time of diagnosis (46 vs. 58 years, p < 0.0001). Liver disease evolved at a faster pace in the MBS group with a shorter time to first hospitalization (5 vs. 13 months, p = 0.036), and consecutive hospitalizations. The proportion with primary hospitalization due to acute‐on‐chronic liver failure (ACLF) was significantly larger in the MBS group (60.9% vs. 27.6%, p < 0.0001), and throughout the following hospitalizations, ACLF remained more prevalent in the MBS group. Modeled transplant‐free survival was lower in the MBS group (p = 0.004), with ACLF as the main cause of death. The weekly amount of alcohol consumed during drinking periods and duration of use were significantly lower in the MBS group.ConclusionsMBS patients hospitalized with ALD develop acute decompensation at a faster pace, with more overall ACLF hospitalizations, and higher cumulative mortality, despite being 12 years younger on average.Clinical trial registrationNot applicable.
Biofilm characterization and dynamic simulation of advanced rope media reactor for the treatment of primary effluent
Authors: Shewa Wudneh A. , Sun Lin , Bossy Kevin , Dagnew Martha 
Published: November 2024

AbstractBiofilm modeling is inherently complex, often requiring multiple assumptions and simplifications. In biofilm modeling, default or literature‐based values in biofilm systems are usually used to estimate biofilm parameters, including boundary layer, biofilm density, thickness, attachment, and detachment rates. This study aimed to characterize and model the biofilm of a specific rope‐type fixed media system, removing carbon and total inorganic nitrogen, coupled with sensitivity analysis. Among the five model parameters, the sensitivity analysis of this study showed that boundary layer thickness is the most influential parameter for predicting effluent ammonia and nitrate concentrations, and biofilm density is most sensitive with respect to effluent chemical oxygen demand (COD). The least sensitive parameter is the detachment rate. Based on the calculated mean absolute error (MAE) and root mean squared error (RMSE), the calibrated BioCord fixed‐film reactor (BFFR) model accurately predicted effluent ammonium and dissolved oxygen (DO) in the continuously aerated bench‐scale reactor (R1) and failed to predict well in the intermittently aerated bench‐scale reactor (R2). RMSE values calculated for NH3‐N and DO in R1 are 0.95 and 0.53 mg/L, respectively. In the BioCord pilot plant's case, ammonium‐N predicted by the model fit the measured values well, while it overpredicted DO concentrations.Practitioner Points
Fixed biofilm BioCord reactors were studied for primary effluent treatment.
A methodology was developed to characterize biofilms.
Boundary layer thickness is the most influential parameter for predicting effluent ammonia and nitrate concentrations.
Biofilm density is the most sensitive parameter with respect to effluent COD.
The calibrated BFFR model can predict effluent ammonium, nitrite, and nitrate‐nitrogen.
Clinicopathological predictive factors in long‐term survivors who underwent surgery for pancreatic ductal adenocarcinoma: A single‐center propensity score matched analysis
Authors: Ingaldi Carlo , D’Ambra Vincenzo , Ricci Claudio , Alberici Laura , Minghetti Margherita , Grego Davide , Cavallaro Virginia , Casadei Riccardo 
Published: November 2024

AbstractBackgroundLong‐term survivors (LTSs) after pancreatic resection of pancreatic ductal adenocarcinoma (PDAC) represent a particular subgroup of patients that remains poorly understood. The primary endpoint was to identify clinicopathological factors associated with LTSs after pancreatic resection for PDAC.MethodsThis was a retrospective study of patients who had undergone pancreatic resection for PDAC. Long survival was defined as a patient who survived at least 60 months. Patients were divided in two groups: LTS and short‐term survivor (STS). The two groups were compared regarding epidemiological, clinical, and pathological data. Propensity score matching (PSM) was used to reduce selection bias with a 1:2 ratio. Multivariable analysis of significative predictive factors before and after PSM was done.ResultsThree hundred and thirty‐three patients were enrolled: 46 (13.8%) in the LTS group and 287 (86.2%) in the STS group. Using PSM, 138 patients were analyzed: 46 in the LTS group and 92 in the STS group. At the multivariate analysis of significative predictive factor after PSM, adjuvant chemotherapy, well‐differentiated tumors (G1), and R0 status were related to long‐term survival (p = 0.052, 0.010 and p = 0.019, respectively). Kaplan–Meier survival curves confirmed these data. Additionally, Kaplan–Meier survival curves showed that pathological stage I was a favorable factor with respect to stage II, III, and IV.ConclusionsLong‐term survival is possible after pancreatic cancer resection, even if in a small percentage. Significant predictors of long‐term survival are administration of adjuvant chemotherapy, American Join Committee on Cancer stage I, well‐differentiated tumor (G1), and R0 resection.
Prehistoric Wetland Sites of Southern Europe: Archaeological Matter, Environmental Context, Research Potential, and Threats to Preservation
Authors: Ballmer Ariane , Hafner Albert , Tinner Willy 
Published: November 2024

AbstractArchaeological remains of dwellings that were originally built in wetland environments and today in many cases are waterlogged, offer rich materials and data due to their outstanding preservation. At the same time, off-site deposits in wetlands bear detailed information on palaeoenvironmental conditions. The unique methodological possibility to correlate archaeological settlementsequences with temporally uninterrupted palaeoenvironmental records in a high temporal resolution, and thus to reconstruct coherent long-term human–environment relationships, is of particular significance. In this opening chapter, the authors introduce the basic parameters of an overarching, contextual perspective to prehistoric wetland settlements of Mediterranean Europe, not only in geographical terms, but also in (inter-) disciplinary, or methodological terms, respectively. Sites from eastern Spain, southern France, Italy, Slovenia, theBalkan Peninsula, and the Bulgarian Black Seacoastare discussed by archaeologists, dendrochronologists, bioarchaeologists, and palaeoecologists. Whereas the waterlogging of the anthropogenic remains and environmental data allow for advanced archaeological and palaeoenvironmental research, at the same time the in situ-preservation of the relevant sites, deposits and findings is at stake due to natural erosion processes and human interventions, as well as increasingly to climate change. To preserve this exceptional cultural heritage, the authors underline the pressing necessity and importance to record, inventory, and protect, or professionally excavate and document these sites.
Pile-Dwellings at Ljubljansko Barje, Slovenia: 25 Years of Dendrochronology
Authors: Velušček Anton , Čufar Katarina 
Published: November 2024

AbstractInterdisciplinary research on the pile-dwellings in the Ljubljansko barje, Slovenia, has been carried out, with brief interruptions, since their discovery in 1875. Since 1995 these efforts have been coordinated by the Institute of Archaeology of the ZRC SAZU. Systematic excavations and interdisciplinary research were carried out on prehistoric pile-dwelling sites, and dendrochronology was introduced as a basic method for determining the time frame of their existence. To this end, wood was collected from 16 sites for wood identification, dendrochronology and radiocarbon dating. Between 1995 and 2017, nearly 8800 samples of waterlogged wood, mainly from the piles the dwellings were built on, were collected and examined. Approximately 20% of the samples were oak (Quercus sp.) and ash (Fraxinus sp.), with more than 45 tree rings selected for dendrochronological study. Oak and ash tree-ring chronologies were established for most of the sites. Site chronologies that overlapped were merged into longer chronologies. Dating was carried out using 14C dating supported by a wiggle-matching procedure, and for the 4th millennium BC settlements with the help of teleconnection with German-Swiss reference chronology from sites approximately 500 km away north of the Alps. For the oldest settlementResnikov prekop, which was already inhabited around 4600 BC, we could not establish a chronology due to the insufficient number of wood samples. The most important tree-ring chronologies of oak are: BAR-3330 (time span 3771–3330 BC) dated by dendrochronology, as well as SG-VO (3285–3109 ± 14 cal BC) and ZA-QUSP1 (2659–2417 ± 18 cal BC) both dated by radiocarbonwiggle-matching). BAR-3330 helped us date eight sites, SG-VO two sites, and ZA-QUSP1 three sites indicating the end of the Copper Age on the Ljubljansko barje. Slovenian oak chronologies from different periods have the potential to be teleconnected with those from other regions.
A Palaeoecological Perspective on the Environmental Impact of Prehistoric Societies in Europe with Emphasis on Greece and the Southern Balkans
Authors: Morales-Molino César , van Vugt Lieveke , Ballmer Ariane , Brechbühl Sarah , Ganz Kathrin , Gassner Sylvia , Gobet Erika , Hafner Albert , Lotter André F. , Senn Carolina , Thévenaz Antoine , Tinner Willy 
Published: November 2024

AbstractHere, we provide an overview on the environmental impact of Europe’s first farmers, focusing on the vegetation shifts that occurred in the southern Balkans during the Neolithisation. First, we draw on recent methodological developments in palaeoecology that contribute to tighten its linkages with archaeology. We start highlighting the importance of highly precise and accurate lake sediment chronologies to enhance comparison with dendrochronologically dated archaeological settlements. Then, we assess modern pollen-vegetation relationships to better interpret the fossil pollen records. The results reveal (i) an overall good match between the main vegetation types of the southern Balkans and their soil pollen assemblages, and (ii) that pollen assemblages from lake surface samples reflect reliably the surrounding vegetation. Afterwards, we summarise our latest results from the region. In Limni Zazari (Greece), continuous pollen recordsof cerealsand ruderal plants allow dating early farming activities around 6250 BC. At Ploča Mičov Grad (Lake Ohrid, North Macedonia), pollen evidence of cereals and weeds place the onset of the Neolithic at 5500–5100 BC, i.e. significantly earlier than the tree-ring inferred age of the settlement. Current efforts aim at producing new palaeoecological records, refining the available ones, and adding palaeoclimaticreconstructionsClimate that allow determining which role climate variability played in the Neolithisation.
Isolino Virginia (Lake Varese, Italy): New Archaeobotanical Research at the Earliest Pile-Dwelling of the Circumalpine Area
Authors: Steiner Bigna L. , Antolín Ferran , Soteras Raül , Rottoli Mauro , Banchieri Daria G. 
Published: November 2024

AbstractThe results of the archaeobotanical analysis and radiocarbon dating programme of the eight cores retrieved from Isolino Virginia (Lake Varese) in 2018 are here presented. We could identify at least two phases of occupation, between 5000 and 4700 and 4250 and 3650 cal BC, with excellent preservation conditions and hence yielding abundant plant macroremains (c. 15,000). The main crops during the 5th millennium cal BC are naked wheat, naked barley, flax, opium poppy and possibly also pea. This crop assemblage connects the site with the Western Mediterranean area instead of the Eastern Italian sites, where glume wheats were the most important crops. Possible changes around 4000 BC are observed. Wild fruit gathering was an important activity during the whole Neolithic occupation of the island.