bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of Illness Behaviors and its Correlates in Patients with Chronic Nonorganic Pain
Authors: Desai Geetha , Kandavel Thennarasu , Chaturvedi Santosh K. 
Published: October 2018

ABSTRACT
Background: Illness behaviors if abnormal can have significant influence in presentations of chronic pain. The aim of the study was to derive the patterns of illness behaviors and its correlates in subjects with chronic nonorganic pain. Methods: Illness Behavior Questionnaire (IBQ) was administered to 301 adult individuals with chronic nonorganic pain. Factor analysis was performed on the IBQ, and relationships of the dimensions of illness behavior with clinical and demographic variables were computed. Results: Majority of the sample consisted of women (n = 208; 69%) with 43% from rural background and 58% from below poverty line status. Principal axis factoring resulted in four factors, namely health concerns, affective inhibition (AI), bodily distress, and affective distress with psychosocial problems. The three factors excluding AI had significant intercorrelation among them. There was significant difference in mean scores of factors, bodily distress and affective distress in patients from urban and rural background. Conclusions: Illness behaviors in chronic nonorganic pain can be understood as three interrelated factors-health concerns, affective distress with psychosocial problems, and bodily distress. AI might be an independent factor for presentation of chronic nonorganic pain.
Collaborative Tele-Neuropsychiatry Consultation Services for Patients in Central Prisons
Authors: Agarwal Preethi Pansari , Manjunatha Narayana , Gowda Guru S. , Girish Kumar M. N. , Shanthaveeranna Neelaveni , Kumar Channaveerachari Naveen , Math Suresh Bada 
Published: October 2018

ABSTRACT
Background: Tele-medicine helps to provide clinical care comparable to in-person treatment in various clinical settings. It is a novel system of healthcare delivery in both low-resource settings and sites where adequate medical care continues to pose greatest challenge like in prison’s in India and worldwide. Aim: To study the sociodemographic and clinical profile of patients from Central Prisons, having received collaborative Tele-Neuropsychiatric Care. Methodology: Psychiatry, neurology, and neurosurgery specialists provided tele-neuropsychiatry consultation through Specialist–Doctor–Patient model as part of the state-run program for the two central prisons from July 1, 2014, to June 30, 2016. A retrospective file review was done of the tele-neuropsychiatry case records at Tele-Medicine Centre, Located at Tertiary Neuro Psychiatric centre of South India. Results: A total of 53 patients were provided tele-neuropsychiatric consultation over 2-year period. Of these, 48 (90.6%) were male and 34 (64.1%) were aged more than 30 years. In total, 20.7% of them had severe mental illness, i.e., schizophrenia and mood disorders, 20.7% with substance use disorder (alcohol and cannabis), 17% had anxiety disorders while 17% with seizure disorder. Nearly 81.1% of patients (inmates) were advised pharmacotherapy while 18.9% were suggested further evaluation of illness and inpatient care at the higher center. Conclusion: The collaborative care was successful in delivering psychiatry, neurology, and neurosurgery consultation with a Specialist–Doctor–Patient model to prison inmates.
Assessing the Value of Routine Pathologic Examination of Resected Femoral Head Specimens After Femoral Neck Fracture
Authors: Davis Jason A. , Rohlfing Geoffrey , Sagouspe Kenan , Brambila Maximino 
Published: October 2018

Introduction:
The purpose of this study was to evaluate the efficacy of routine pathologic examination (PE) of femoral head (FH) specimens after arthroplasty for acute femoral neck fractures and to determine the cost.

Methods:
This was a retrospective chart review of 850 acute femoral neck fractures treated with hemiarthroplasty or total hip arthroplasty These were evaluated to determine whether the FH was sent for PE, the resultant findings, alterations in medical treatment, and cost.

Results:
A total of 466 FH specimens (54.8%) were sent to pathology. Four (0.9%) were positive for a neoplastic process. All four had a known history of cancer, antecedent hip pain, or an inappropriate injury mechanism. None of the findings resulted in an alteration in medical treatment. The average cost of PE was $195 USD.

Discussion:
The routine PE of FH specimens after arthroplasty for femoral neck fractures is not warranted and uneconomic. Sending the FH for PE, only when clinically indicated, rather than routine, will result in notable savings for the healthcare system.

Level of Evidence:
Level IV
The Primary Medicine Initiative—Continuity in medical education
Authors: Wood Douglas L. 
Published: October 2018

Abstract
Primary care will play a central role in the new national healthcare program. Our osteopathic medical education programs must change if osteopathic physicians are to remain dominant in primary care and thereby play a large role in the revamped healthcare system. This article outlines a pilot program currently in development at the Michigan State University College of Osteopathic Medicine (MSU-COM). H successful, the MSU-COM program could be used as a blueprint for a similar nationwide program in osteopathic medical education.
Effects of osteopathic manipulative treatment in patients with cervicothoracic pain: Pilot study using thermography
Authors: Walko Edward J. , Janouschek Christine 
Published: October 2018

Abstract
To provide information on how cervicothoracic pain responds to osteopathic manipulative treatment, five subjects with acute or chronic pain received appropriate medication and three osteopathic manipulative treatments by the principal investigator using thrust and nonthrust techniques. The mean number of findings by both investigators on structural examination decreased considerably immediately after each of the three treatments. The number of findings increased in week 2 and decreased in week 3. The prinicpal investigator observed a further decrease by the final session, but the coinvestigator reported an increase. The pain scale score improved an average of nearly 3Wo. Thermography showed cooling of the cervicothoracic region in all subjects and conversion to a normal pattern in four. Osteopathic manipulative treatment should be considered for patients with acute or chronic cervicothoracic pain. The use of thermographic analysis in clinical osteopathic research seems warranted.
False-positive malignant peritoneal cytology associated with pelvic endometriosis
Authors: Markuly Sotirios N. , Fanning James , Hindman Travis L. , Galle Phillip C. , Ertmoed Ernest , Hilgers Robert D. 
Published: October 2018

Abstract
The peritoneal washings obtained at diagnostic laparoscopy of two women with suspected endometriosis contained cells with cytologic features of adenocarcinoma. Exploratory laparotomy, total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and pelvic washings confirmed endometriosis with no evidence of cancer. At 1.5-year and 4.0-year follow-up, respectively, cancer had not developed in either patient. The authors report what they were able to find in the literature regarding false-positive assessments of malignancy obtained by cytologic examination. They also outline steps to be taken should a diagnosis of malignancy arise in a woman with endometriosis who desires pregnancy.
Unusual manifestations of thoracic actinomycosis
Authors: Bentley Evert Randall , Ostransky David 
Published: October 2018

Abstract
Actinomycosis is a chronic, suppurative bacterial infection characterized by multiple abscesses, sinus tracts, fibrosis, and granulation involving the face, neck, thorax, or abdomen. Thoracic actinomycosis probably results from aspiration of oropharyngeal secretions. Its description in the literature is extensive. Reported herein are two cases of thoracic actinomycosis with unusual manifestations exemplifying the organism's lack of regard for fascial planes. The authors present a comprehensive review of actinomycosis in order to encourage early diagnosis. The importance of bedside examination and inspection of available material stained by Gram's method are emphasized. Computed tomography scanning is a useful adjunct for assessing the anatomic extent of this disease.
Utility of GDF‐15 as a diagnostic biomarker in gastric cancer: an investigation combining GEO, TCGA and meta‐analysis
Authors: Liu Jie‐yu , Dong Xing‐xuan , Lu Jia‐nan , Zhang Yue , Liu Kai‐fan , Liu Ling‐feng , E Qing‐zhi , Lu Xiao‐jing , Yin Jie‐yun , Shen Yue‐ping 
Published: October 2018

It was recently suggested that growth differentiation factor‐15 (GDF‐15) is associated with gastric cancer (GC) carcinogenesis. However, the diagnostic potential of GDF‐15 for GC remains unclear. To address this issue, we obtained RNA sequencing and microarray data from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases, and searched PubMed, Google Scholar and Web of Science for relevant literature. We then used STATA to perform a meta‐analysis. In total, reports of 253 GC patients and 112 healthy controls who contributed peripheral blood samples were taken from the four literature sources, while information on 754 GC tumor and 263 gastric normal tissues was drawn from TCGA and seven GEO datasets. The expression level of GDF‐15 mRNA was significantly higher in tumor tissues than in normal tissues, with a standard mean difference (SMD) of 0.79% and a 95% confidence interval (95% CI) of 0.63–0.95. Consistently, the GDF‐15 protein in blood was significantly increased in GC patients as compared to controls (SMD = 3.74, 95% CI = 1.81–5.68). In addition, based on information from TCGA and GEO datasets, the expression level of GDF‐15 mRNA may be of use for the diagnosis of GC, with a combined sensitivity, specificity and odds ratio of 0.69 (95% CI = 0.58–0.79), 0.90 (95% CI = 0.84–0.93) and 6.32 (95% CI = 4.22–9.49), respectively. The summary receiver operating characteristic curve demonstrated that the area under the curve was 0.90 (95% CI = 0.87–0.93). The results suggest higher levels of GDF‐15 may be associated with GC tumorigenesis and may have the potential to be a diagnostic biomarker of GC.
Material Design for Photocatalytic Water Splitting from a Theoretical Perspective
Authors: Fu Cen‐Feng , Wu Xiaojun , Yang Jinlong 
Published: October 2018

AbstractCurrently, problems associated with energy and environment have become increasingly serious. Producing hydrogen, a clean and renewable resource, through photocatalytic water splitting using solar energy is a feasible and efficient route for resolving these problems, and great efforts have been devoted to improve the solar‐to‐hydrogen efficiency. Light harvesting and electron–hole separation are key in enhancing the efficiency of solar energy utilization, which stimulates the development of new photocatalytic materials. Here, recent advances in material design for photocatalytic water splitting are presented from a theoretical perspective. Specifically, aiming to enhance the photocatalytic performance, general strategies of materials design are discussed, including codoping and introducing a built‐in electric field to improve the light harvesting of materials, reducing the dimension of materials to shorten the migration pathway of carriers to inhibit electron–hole recombination, and constructing heterojunctions to enhance light harvesting and electron–hole separation. Future opportunities and challenges in the theoretical design of photocatalytic materials toward water splitting are also included.
A phase II study of omacetaxine mepesuccinate for patients with higher‐risk myelodysplastic syndrome and chronic myelomonocytic leukemia after failure of hypomethylating agents
Authors: Short Nicholas J. , Jabbour Elias , Naqvi Kiran , Patel Ami , Ning Jing , Sasaki Koji , Nogueras‐Gonzalez Graciela M. , Bose Prithviraj , Kornblau Steven M. , Takahashi Koichi , Andreeff Michael , Sanchez‐Petitto Gabriela , Estrov Zeev , Dinardo Courtney D. , Montalban‐Bravo Guillermo , Konopleva Marina , Alvarado Yesid , Bhalla Kapil N. , Fiskus Warren , Khouri Maria , Islam Rubiul , Kantarjian Hagop , Garcia‐Manero Guillermo 
Published: October 2018

AbstractThe outcome of patients with myelodysplastic syndromes (MDSs) after failure of hypomethylating agents (HMAs) failure is poor with a median overall survival (OS) of only 4‐6 months. Omacetaxine mepesuccinate (OM) is safe and effective in myeloid malignancies but has not been studied in MDS with HMA failure. We conducted a phase II study of OM in patients with MDS or chronic myelomonocytic leukemia (CMML) who had previously failed or been intolerant to HMAs. Patients received OM at a dose of 1.25 mg/m2 subcutaneously every 12 hours for 3 consecutive days on a 4‐ to 7‐week schedule. The primary endpoints were the overall response rate (ORR) and OS. A total of 42 patients were enrolled with a median age of 76 years. The ORR was 33%. Patients with diploid cytogenetics were more likely to respond to OM than were those with cytogenetic abnormalities (58% vs 23%, respectively; P = .03). Overall, the median OS was 7.5 months and 1‐year OS rate was 25%. Patients with diploid cytogenetics had superior OS to those with cytogenetic abnormalities (median OS 14.8 vs 6.8 months, respectively; P = .01). Two patients had ongoing response to OM of 2 years or longer (both MDS with diploid cytogenetics and RUNX1 mutation). The most common grade ≥ 3 adverse events were infections in 11 patients (26%), febrile neutropenia in 4 (10%), and hemorrhage in 3 (7%). Overall, OM was safe and active in patients with MDS or CMML who experienced HMA failure. These results support the further development of OM in this setting.
Novel screening criteria for post‐traumatic venous thromboembolism by using D‐dimer
Authors: Iyama Keita , Inokuma Takamitsu , Sato Shuntaro , Yamano Shuhei , Tajima Goro , Hirao Tomohito , Tasaki Osamu 
Published: October 2018

AimBecause severe trauma patients frequently manifest coagulopathy, it is extremely important to detect venous thromboembolism (VTE) in the acute phase. However, no reference value for D‐dimer in post‐traumatic VTE has been reported given the substantial increase in its levels after injury. Therefore, this study evaluates the ability of our screening criteria using D‐dimer to detect VTE in severe trauma patients.MethodsTrauma patients (n = 455) who were admitted to our emergency medical center during October 2011–June 2015 were included in this study. To prevent VTE, intermittent pneumatic compression was carried out in most patients. Our screening criteria included the following: (i) ≥5 days of hospital stay, (ii) increasing D‐dimer levels across 3 measuring days, (iii) D‐dimer levels ≥15 μg/mL. Patients who met these screening criteria underwent contrast‐enhanced computed tomography (CE‐CT) to detect VTE.ResultsDuring the study period, 108 cases satisfied the screening criteria; 73 of these underwent CE‐CT, 34 of whom were diagnosed with VTE (positive predictive value, 46.6%). The median hospital stay on satisfying the screening criteria and before undergoing CE‐CT was 7 and 10 days, respectively. No patient had VTE symptoms at the time of diagnosis. Also, none of the remaining 347 patients who did not satisfy the screening criteria had VTE symptoms.ConclusionThe screening criteria using D‐dimer presented herein can be used as reference for efficiently detecting VTE in severe trauma patients.
Levodopa‐induced dyskinesia in Parkinson disease: Sleep matters
Authors: Amato Ninfa , Manconi Mauro , Möller Jens C. , Sarasso Simone , Stanzione Paolo , Staedler Claudio , Kaelin‐Lang Alain , Galati Salvatore 
Published: October 2018

ObjectiveThe spectrum of clinical symptom changes during the course of Parkinson disease (PD). Levodopa therapy, while offering remarkable control of classical motor symptoms, causes abnormal involuntary movements as the disease progresses. This levodopa‐induced dyskinesia (LID) has been associated with abnormal cortical plasticity. Because slow wave activity (SWA) of nonrapid eye movement (NREM) sleep underlies adjustment of cortical excitability, we sought to elucidate the relationship between this physiological process and LID.MethodsThirty‐six patients at different stages of PD underwent whole‐night video polysomnography–high‐density electroencephalography (vPSG‐hdEEG), preceded by 1 week of actigraphy. To represent the broad spectrum of the disease, patients were divided into 3 groups by disease stage—(1) de novo (n = 9), (2) advanced (n = 13), and (3) dyskinetic (DYS; n = 14)—were compared to an age‐matched control group (n = 12). The SWA‐NREM content of the vPSG‐hdEEG was then temporally divided into 10 equal parts, from T1 to T10, and power and source analyses were performed. T2‐T3‐T4 were considered early sleep and were compared to T7‐T8‐T9, representing late sleep.ResultsWe found that all groups, except the DYS group, manifested a clear‐cut SWA decrease between early and late sleep.InterpretationOur data demonstrate a strong pathophysiological association between sleep and PD. Given that SWA may be a surrogate for synaptic strength, our data suggest that DYS patients do not have adequate synaptic downscaling. Further analysis is needed to determine the effect of drugs that can enhance cortical SWA in LID. Ann Neurol 2018;84:905–917
Chemoselektive α,β‐Dehydrierung von gesättigten Amiden
Authors: Teskey Christopher J. , Adler Pauline , Gonçalves Carlos R. , Maulide Nuno 
Published: October 2018

AbstractWir berichten über eine Methode zur selektiven α,β‐Dehydrierung von Amiden in der Gegenwart von anderen Carbonylgruppen unter milden Bedingungen. Unsere Strategie basiert auf elektrophiler Aktivierung, verbunden mit einer in situ selektiven, Selen‐vermittelten Dehydrierung. Die α,β‐ungesättigten Produkte werden in moderaten bis exzellenten Ausbeuten gewonnen, und ihre Vielseitigkeit wird anhand einiger Transformationen demonstriert. Mechanistische Experimente lassen auf die Bildung einer elektrophilen SeIV‐Spezies schließen.
Emerging Applications of Nanotechnology for Controlling Cell‐Surface Receptor Clustering
Authors: Zhang Kaixiang , Gao Hua , Deng Ruijie , Li Jinghong 
Published: October 2018

AbstractThe spatial organization of cell‐surface receptors plays an important role in defining cell fate. Recently, the development of strategies for the direct regulation of receptor clustering using nanomaterials has aroused enormous interest. In this review, we discuss the mechanisms and features of recently developed nanomaterial‐based strategies to control the nanoscale distribution of cell binding ligands and regulate cell behavior. We expect this review to inspire innovative work on manipulating cell functions by controlling the clustering of cell surface receptors.
α‐MnO2 Nanowire‐Anchored Highly Oxidized Cluster as a Catalyst for Li‐O2 Batteries: Superior Electrocatalytic Activity and High Functionality
Authors: Gu Tae‐Ha , Agyeman Daniel Adjei , Shin Seung‐Jae , Jin Xiaoyan , Lee Jang Mee , Kim Hyungjun , Kang Yong‐Mook , Hwang Seong‐Ju 
Published: October 2018

AbstractAn effective chemical way to optimize the oxygen electrocatalyst and Li‐O2 electrode functionalities of metal oxide can be developed by the control of chemical bond nature with the surface anchoring of highly oxidized selenate (SeO42−) clusters. The bond competition between (Se6+−O) and (Mn−O) bonds is quite effective in stabilizing Jahn–Teller‐active Mn3+ state and in increasing oxygen electron density of α‐MnO2 nanowire (NW). The selenate‐anchored α‐MnO2 NW shows excellent oxygen electrocatalytic activity and electrode performance for Li‐O2 batteries, which is due to the improved charge transfer kinetics and reversible formation/decomposition of Li2O2. The present study underscores that the surface anchoring of highly oxidized cluster can provide a facile, effective way of improving the oxygen electrocatalyst and electrochemical performances of nanostructured metal oxide in Li‐O2 cells.
Plasma‐Triggered Synergy of Exfoliation, Phase Transformation, and Surface Engineering in Cobalt Diselenide for Enhanced Water Oxidation
Authors: Wang Xin , Zhuang Linzhou , Jia Yi , Liu Hongli , Yan Xuecheng , Zhang Longzhou , Yang Dongjiang , Zhu Zhonghua , Yao Xiangdong 
Published: October 2018

AbstractVarious strategies, such as increasing active site numbers and structural and surface engineering, have been used to improve the oxygen evolution reaction (OER) performance of transition‐metal dichalcogenides. However, it is challenging to combine these strategies in one system to realize the full catalytic potential. Now, an Ar/O2 plasma method is used to simultaneously induce exfoliation, surface reorganization (formation of an oxidative layer with rich oxygen vacancies), and phase transformation (cubic‐to‐orthorhombic) on CoSe2 to generate an exceptionally outstanding OER electrocatalysts. The as‐made samples require an overpotential of only 251 mV at 10 mA cm−2, outperforming commercial RuO2 and most reported OER catalysts. The striking catalytic activity originates from the optimized chemical and electronic environment. This work provides valuable insights into the design of promising OER electrocatalysts with high natural abundance via multilevel structural modulation.
Functionalization of Carbon Monoxide and tert‐Butyl Nitrile by Intramolecular Proton Transfer in a Bis(Phosphido) Thorium Complex
Authors: Vilanova Sean P. , del Rosal Iker , Tarlton Michael L. , Maron Laurent , Walensky Justin R. 
Published: October 2018

AbstractWe report intramolecular proton transfer reactions to functionalize carbon monoxide and tert‐butyl nitrile from a bis(phosphido) thorium complex. The reaction of (C5Me5)2Th[PH(Mes)]2, Mes=2,4,6‐Me3C6H2, with 1 atm of CO yields (C5Me5)2Th(κ2‐(O,O)‐OCH2PMes‐C(O)PMes), in which one CO molecule is inserted into each thorium–phosphorus bond. Concomitant transfer of two protons, formerly coordinated to phosphorus, are now bound to one of the carbon atoms from one of the inserted CO molecules. DFT calculations were employed to determine the lowest energy pathway. With tert‐butyl nitrile, tBuCN, only one nitrile inserts into a thorium–phosphorus bond, but the proton is transferred to nitrogen with one phosphido remaining unperturbed affording (C5Me5)2Th[PH(Mes)][κ2‐(P,N)‐N(H)C(CMe3)P(Mes)]. Surprisingly, reaction of this compound with KN(SiMe3)2 removes the proton bound to nitrogen, not phosphorus.
Enantioselective Formal C(sp3)−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives
Authors: Li Houhua , Gontla Rajesh , Flegel Jana , Merten Christian , Ziegler Slava , Antonchick Andrey P. , Waldmann Herbert 
Published: October 2018

AbstractHerein, we report the first enantioselective annulation of α‐arylidene pyrazolones through a formal C(sp3)−H activation under mild conditions enabled by highly variable RhIII‐Cpx catalysts. The method has a wide substrate scope and proceeds with good to excellent yields and enantioselectivities. Its synthetic utility was demonstrated by the late‐stage functionalization of drugs and natural products as well as the preparation of enantioenriched [3]dendralenes. Preliminary biological investigations also identified the spiropyrazolones as a novel class of Hedgehog pathway inhibitors.