bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of epidermal growth factor receptor and its downstream effector, focal adhesion kinase, correlates with papillary thyroid carcinoma progression
Authors: Šelemetjev Sonja , Bartolome Aleksandar , Išić Denčić Tijana , Đorić Ilona , Paunović Ivan , Tatić Svetislav , Cvejić Dubravka 
Published: April 2018

SummaryEpidermal growth factor receptor (EGFR) and its downstream effector, focal adhesion kinase (FAK), have been shown to be overexpressed frequently in human malignancies and implicated in tumour aggressiveness. We aimed to investigate the relationship between EGFR and FAK expression and their possible correlation with the clinical phenotype of patients with papillary thyroid carcinoma (PTC). Expression profiles of EGFR and FAK were analysed in PTC tissue samples (n = 104) by immunohistochemistry and Western blotting. Additionally, EGFR and FAK were immunohistochemically analysed in 20 primary tumours paired with their metastatic tissue in lymph nodes. High expression of EGFR and FAK was found in 55.77% and 57.69% cases, respectively, with a strong positive association between them (P < 0.0001, Spearman's correlation coefficient = 0.844). Expression of each molecule and their coexpression correlated significantly with the presence of lymph node metastasis (LNM), degree of tumour infiltration, extrathyroid invasion and pT status of the patients. Western blot analysis confirmed that coexpression of high levels of EGFR and FAK correlated with adverse clinicopathological features. When compared to the corresponding primary tumour, increased or maintained high levels of EGFR and FAK were found in LNM, indicating their concordant expression during lymphatic spread. In conclusion, high levels of EGFR and its downstream effector, FAK, in association with lymphatic spread and tumour infiltration indicate their involvement in PTC progression and suggest that both molecules may predict its aggressive behaviour. Furthermore, FAK could be a potential target for anticancer therapy in patients with advanced thyroid cancer.
Microbial inactivation and quality improvement of tomatoes treated by package film with allyl isothiocyanate vapour
Authors: Gao Haiyan , Wu Weijie , Chen Hangjun , Qin Yanhong , Fang Xiangjun , Jin Tony Z. 
Published: April 2018

SummaryIn‐package sanitisation was developed using polylactic acid (PLA) films with allyl isothiocyanate (AIT) vapour. Tomatoes were artificially inoculated with Escherichia coli, Geotrichum candidum and Fusarium oxysporum and stored in clamshell boxes with the film fixed to the underside of the lid. The changes in bacterial and fungal populations and the quality of tomatoes during storage at 4 and 10 °C were evaluated. The results revealed that the film treatment (4 × 8 cm2 film in 1 L box) reduced the populations of inoculated bacteria and fungi on tomatoes by 2–3 log CFU g−1, and then significantly (P < 0.05) inhibited their growth during the 21‐day storage period at both temperatures. Tomatoes subject to film treatment had fewer changes in quality (colour, firmness, contents of total soluble solid, titratable acids and vitamin C) than the control samples during storage. The antimicrobial PLA film can be used for in‐package sanitisation to extend the shelf‐life of packaged tomatoes or similar perishable vegetables.
Comparative production of xylanase and the liberation of xylooligosaccharides from lignocellulosic biomass by Aspergillus brasiliensis BLf1 and recombinant Aspergillus nidulans XynC A773
Authors: da Silva Menezes Bruna , Rossi Daniele Misturini , Squina Fabio , Ayub Marco Antônio Záchia 
Published: April 2018

SummaryWe investigated the simultaneous production of xylanase and the liberation of xylooligosaccharides in rice husk solid‐state cultivations of Aspergillus brasiliensis BLf1 and by the recombinant Aspergillus nidulans XynC A773 strain. The bioprocess was optimised by experimental fractional design and response surface analysis. Results show that both fungi strains produced xylanases and their activities were dependent on the addition of basal medium, moisture content and the interactions between particle size and inoculum size, producing maximum xylanase activities of 230.7 U g−1 substrate for A. brasiliensis, and 187.9 U g−1 substrate for A. nidulans XynC. Xylooligosaccharides were liberated in the same cultures, with concentrations up to 17.6 mg g−1 and 23.9 mg g−1 of substrate for A. brasiliensis and A. nidulans XynC, respectively, both strains presenting similar profiles, with xylose residues varying from X3 to X6. These results suggest the possibility of lowering production costs of enzymes for food applications and oligosaccharides.
Dilute Russel Viper Venom Time analysis in a Haematology Laboratory: An audit
Authors: Kruger W. , Meyer P. W. A. , Nel J. G. 
Published: April 2018

AbstractIntroductionTo determine whether the current set of evaluation criteria used for dilute Russel Viper Venom Time (dRVVT) investigations in the routine laboratory meet expectation and identify possible shortcomings.MethodsAll dRVVT assays requested from January 2015 to December 2015 were appraised in this cross‐sectional study. The raw data panels were compared with the new reference interval, established in 2016, to determine the sequence of assays that should have been performed. The interpretive comments were audited, and false‐negative reports identified. Interpretive comments according to three interpretation guidelines were compared. The reagent cost per assay was determined, and reagent cost wastage, due to redundant tests, was calculated.ResultsOnly ~9% of dRVVT results authorized during 2015 had an interpretive comment included in the report. ~15% of these results were false‐negative interpretations. There is a significant statistical difference in interpretive comments between the three interpretation methods. Redundant mixing tests resulted in R 7477.91 (~11%) reagent cost wastage in 2015.ConclusionsWe managed to demonstrate very evident deficiencies in our own practice and managed to establish a standardized workflow that will potentially render our service more efficient and cost effective, aiding clinicians in making improved treatment decisions and diagnoses. Furthermore, it is essential that standard operating procedures be kept up to date and executed by all staff in the laboratory.
Doctrinal Drift, Dance or Development: How Truth Takes Time in the Life of Communion
Authors: Cohen Will 
Published: April 2018

AbstractIn recent ecclesiology, which highlights the value of diversity and dialogue and the difficulty of resolving complex issues, the concept of doctrinal development is sometimes reduced merely to the notion that we cannot be sure of things we once thought we knew. While affirming the need for ecclesial humility and uncertainty, the article insists that a truly questioning church is one that also has hope of arriving, eventually, at answers to history's new questions. Passages from Scripture, Augustine and J.H. Newman are used to show that in recent ecclesiological statements of the Anglican Primates, the World Council of Churches and the Catholic theologian Stan Chu Ilo commenting on the 2014–15 Synods on the Family, an imbalanced vision of a church of only questions – prone to doctrinal drift or ‘dance’ – has supplanted a proper vision of a church of both questions and answers, in which authentic development of doctrine is possible.
Before Deification Became Eastern: Newman's Ecumenical Retrieval
Authors: McInroy Mark 
Published: April 2018

AbstractJohn Henry Newman spearheaded one of the first modern retrievals of the Christian doctrine of deification. This article argues that, precisely because of the early date of Newman's rehabilitation, his treatment is not tinted by the polemics surrounding theosis that developed in the late nineteenth century between Eastern and Western Christianity. To Newman, deification is not an Eastern doctrine, it is not cause for division between East and West, and it does not supplant justification. Instead, it arises from a broad patristic consensus, it is a tool for union among the churches, and it provides resources for understanding justification properly.
Orthodox Christian Reception of the Pauline Teaching on Dikaiosynē: Chrysostom, in Conversation with Calvin, on Romans 1–3
Authors: Humphrey Edith M. 
Published: April 2018

AbstractIn the light of common preconceptions regarding polarized approaches to atonement in Eastern and Western Christianity, this article mainly looks to John Chrysostom's readings of Romans 1–3 for clarity on the Pauline themes of justice, righteousness and justification, putting these alongside the exegesis of a representative Reformer, John Calvin. The ancient theologian of the East gives full attention to the apostle's picturesque metaphors for atonement, including a robust but balanced treatment Paul's forensic language; Calvin is clearly appreciative of the judicial language, but also places it within a larger context (though not identically to Chrysostom). Chrysostom's approach to atonement is showcased also in his neglected sermon on the Ascension of Christ, where forensic language jostles with pictures of reconciliation, sacrifice, mediation and Christus Victor. The article makes a plea that scholars from both East and West read such representative theologians (along with the New Testament itself) with care, not exaggerating their differences. It is noteworthy, for example, that both Chrysostom and Calvin depict salvation as anticipating far more than bare acquittal before God. Chrysostom in particular uses the language of righteousness and justification to speak of a hope for glory, or, to use the Eastern terminology, theōsis. Such sober and anti‐reactionary examination is essential in both academic and ecumenical discussion, and may also help in arbitrating between insights of the so‐called ‘Old’ and ‘New Perspectives’ in Paul.
Newman's Forensic Classic of Development: Its Uniqueness and Its Agon with Gibbon and Surrogates
Authors: O'Regan Cyril 
Published: April 2018

AbstractIn this article I argue for the uniqueness of The Development of Doctrine vis‐à‐vis other classic texts on doctrinal development supplied by the German theologians J.S. Drey and J.A. Möhler. Whereas the accounts of the German theologians are ‘theological’ in the strict sense, Newman's is theological only indirectly and forensic in its primary construction and execution. By ‘forensic’ I mean that the bulk of his reasoning is argumentative and intends to clear a space for thinking plausibly of the development of doctrine given other assumptions in the secular imaginary. While I make plain that in his classic text Newman is taking issue with the barriers against the idea of development from a number of religious constituencies, I suggest that in the end the enemy of enemies are religious rationalists, especially those with a historical sense largely derived from reading Edward Gibbon. Although The Development of Doctrine is an extraordinary text in so many ways, it comes to life when one understands it as Newman doing battle with Gibbon over the proper historiography of Christianity over the ages.
Purely off‐clamp robotic partial nephrectomy: Preliminary 3‐year oncological and functional outcomes
Authors: Simone Giuseppe , Misuraca Leonardo , Tuderti Gabriele , Minisola Francesco , Ferriero Mariaconsiglia , Romeo Giuseppe , Costantini Manuela , Al‐Rawashdah Samer F , Guaglianone Salvatore , Gallucci Michele 
Published: April 2018

ObjectivesTo describe our surgical technique and to report perioperative, 3‐year oncological and functional outcomes of a single‐center series of purely off‐clamp robotic partial nephrectomy.MethodsA prospective renal cancer institutional database was queried, and data of consecutive patients treated with purely off‐clamp robotic partial nephrectomy between 2010 and 2015 in a high‐volume center were collected. Perioperative complications, and 3‐year oncological and functional outcomes were assessed. Univariable and multivariable analyses were carried out to identify independent predictors of renal function deterioration.ResultsOut of 308 patients treated, 41 (13.3%) experienced perioperative complications, 2.9% of which were Clavien grade ≥3. The 3‐year local recurrence‐free survival and renal cell carcinoma‐specific survival rates were 99.5% and 97.9%, respectively. No patient with preoperative chronic kidney disease stage ≤3B developed severe renal function deterioration (chronic kidney disease stage 4) at 1‐year follow up. At multivariable analysis, preoperative estimated glomerular filtration rate (P = 0.005) was the only independent predictor of a new‐onset chronic kidney disease stage ≥3 in patients with preoperative chronic kidney disease stages 1 or 2.ConclusionsOff‐clamp robotic partial nephrectomy is a safe surgical approach in tertiary referral centers, with adequate oncological outcomes and negligible impact on renal function.
Memory vs memory‐like: The different facets of CD8+ T‐cell memory in HCV infection
Authors: Hofmann Maike , Wieland Dominik , Pircher Hanspeter , Thimme Robert 
Published: April 2018

SummaryMemory CD8+ T cells are essential in orchestrating protection from re‐infection. Hallmarks of virus‐specific memory CD8+ T cells are the capacity to mount recall responses with rapid induction of effector cell function and antigen‐independent survival. Growing evidence reveals that even chronic infection does not preclude virus‐specific CD8+ T‐cell memory formation. However, whether this kind of CD8+ T‐cell memory that is established during chronic infection is indeed functional and provides protection from re‐infection is still unclear. Human chronic hepatitis C virus infection represents a unique model system to study virus‐specific CD8+ T‐cell memory formation during and after cessation of persisting antigen stimulation.
Memory control by the B cell antigen receptor
Authors: Engels Niklas , Wienands Jürgen 
Published: April 2018

SummaryThe generation of memory B cells (MBCs) that have undergone immunoglobulin class switching from IgM, which dominates primary antibody responses, to other immunoglobulin isoforms is a hallmark of immune memory. Hence, humoral immunological memory is characterized by the presence of serum immunoglobulins of IgG subtypes known as the γ‐globulin fraction of blood plasma proteins. These antibodies reflect the antigen experience of B lymphocytes and their repeated triggering. In fact, efficient protection against a previously encountered pathogen is critically linked to the production of pathogen‐specific IgG molecules even in those cases where the primary immune response required cellular immunity, for example, T cell‐mediated clearance of intracellular pathogens such as viruses. Besides IgG, also IgA and IgE can provide humoral immunity depending on the microbe's nature and infection route. The molecular mechanisms underlying the preponderance of switched immunoglobulin isotypes during memory antibody responses are a matter of active and controversial debate. Here, we summarize the phenotypic characteristics of distinct MBC subpopulations and discuss the decisive roles of different B cell antigen receptor isotypes for the functional traits of class‐switched B cell populations.
Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts
Authors: Raud Brenda , McGuire Peter J , Jones Russell G , Sparwasser Tim , Berod Luciana 
Published: April 2018

SummaryCD8+ T cells are key members of the adaptive immune response against infections and cancer. As we discuss in this review, these cells can present diverse metabolic requirements, which have been intensely studied during the past few years. Our current understanding suggests that aerobic glycolysis is a hallmark of activated CD8+ T cells, while naive and memory (Tmem) cells often rely on oxidative phosphorylation, and thus mitochondrial metabolism is a crucial determinant of CD8+ Tmem cell development. Moreover, it has been proposed that CD8+ Tmem cells have a specific requirement for the oxidation of long‐chain fatty acids (LC‐FAO), a process modulated in lymphocytes by the enzyme CPT1A. However, this notion relies heavily on the metabolic analysis of in vitro cultures and on chemical inhibition of CPT1A. Therefore, we introduce more recent studies using genetic models to demonstrate that CPT1A‐mediated LC‐FAO is dispensable for the development of CD8+ T cell memory and protective immunity, and question the use of chemical inhibitors to target this enzyme. We discuss insights obtained from those and other studies analyzing the metabolic characteristics of CD8+ Tmem cells, and emphasize how T cells exhibit flexibility in their choice of metabolic fuel.
Sensory strategies in adult mental health: A qualitative exploration of staff perspectives following the introduction of a sensory room on a male adult acute ward
Authors: Forsyth Angus S. , Trevarrow Rebecca 
Published: April 2018

AbstractIn recent years, there has been growing interest in the use of sensory techniques to help with emotional regulation in adult mental health populations. This is against a backdrop of international policies aimed at reducing restrictive interventions and improving the effectiveness of de‐escalation techniques. A sensory room was designed and implemented on a male adult acute psychiatric ward. Staff perspectives were sought to evaluate the effectiveness of the room in managing emotional distress by exploring staff awareness of a broader range of de‐escalation strategies and by exploring what effect the room had on staff behaviours with respect to sensory interventions. A series of semi‐structured interviews were carried out, analysed, and grouped into themes. Three themes emerged as follows: enhancing de‐escalation, sensory interventions, and impact on staff. Findings showed that increased awareness of sensory processing and use of sensory strategies such as the sensory room were perceived by staff to have a positive impact on reducing distress with male service users. Staff use of the room was also discovered to have benefits that included staff attending to their own emotional needs and the use of the room supporting reflective learning during critical incident debriefing.
Digital innovation:Areview and synthesis
Authors: Kohli Rajiv , Melville Nigel P. 
Published: April 2018

AbstractOrganizations are under increasing pressure to apply digital technologies to renew and transform their business models. A great deal of research has examined specific phenomena, such as adoption antecedents and design methods. However, it is unclear what we know in totality, including what research streams exist, how they fit together, and fruitful opportunities for new knowledge development. We combine scientometric and systematic literature review methodologies to examine 7 dimensions of an adapted theoretical framework: initiation; development; implementation; exploitation; the role of the external competitive environment; role of internal organizational environment; and product, service, and process outcomes. From a macro perspective, we find vastly uneven coverage of research streams, diversity and diffusiveness of research, and knowledge and learning as an underlying conceptual pillar. Combined with our summary of each of the 7 research streams, these findings suggest several areas of future research, which we develop by identifying oppositions and tensions.
The relative efficacy of two exercise methods for older adults with chronic low back pain: A preliminary randomized control study
Authors: Salas Eric , Hulla Ryan , Vanzzini Nikeis , Trowbridge Cynthia , Brotto Marco , Keller David , Gatchel Robert J. 
Published: April 2018

AbstractThe objective of the current study was to examine the relative efficacy of two exercise techniques—a multidimensional treatment (MDT) and a traditional senior exercise therapy treatment (TET)—in older adults diagnosed with chronic low back pain (CLBP). Participants (N = 16) were randomly assigned to either the MDT (n = 8) or TET (n = 8) groups after meeting the requirements for the presence of CLBP. Participants in the MDT group received an individualized exercise program, while participants in the TET participated in a group exercise program. A Mann–Whitney test was conducted to determine differences between psychosocial and physical variables pre‐ and post‐intervention. Statistical analyses indicated no significant differences in physical or psychosocial variables at pre‐intervention assessment. However, participants in the MDT group reported a decrease in fatigue and pain interference, with an increase in physical functioning, when compared to the TET group. Additionally, the MDT group displayed a significant decrease pain interference, while the TET group had an increase grip strength. Patients who received the MDT reported less fatigue and pain interference, and an increase in their overall physical functioning. Overall, the MDT was a more efficacious method to manage CLBP.
Growth of diopside crystals in CMAS glass‐ceramics using Cr2O3 as a nucleating agent
Authors: Shi Yu , Li Bao‐Wei , Zhao Ming , Zhang Ming‐Xing 
Published: April 2018

AbstractCaO–Al2O3–MgO–SiO2 (CAMS)‐based glass‐ceramics were prepared using body crystallization method. Adding Cr2O3 into the ceramics not only effectively lowered the crystallization temperature, but also led to significant grain refinement of diopside that crystallized in the CAMS glass‐ceramic after crystallization treatment at 900°C for 2 hours. Experimental work verified that the epitaxial growth of the diopside on the spinel particles, which formed during nucleation treatment when fabricating the glass‐ceramics, facilitated the heterogeneous nucleation of diopside on the spinel and refined the diopside. In addition, two energetically favored crystallographic orientation relationships between the epitaxial growth diopside and spinel were experimentally observed. They are //[001]diopside,////(200)diopside and //[101]diopside, (311)spinel//. These two novel results can be potentially used to develop new glass‐ceramic materials with improved performance.
Synthesis and luminescence properties of single‐component Ca5(PO4)3F:Dy3+, Eu3+ white‐emitting phosphors
Authors: Yu Meng , Zhang Wentao , Qin Shiyu , Li Junfeng , Qiu Kehui 
Published: April 2018

AbstractA series of Ca5(PO4)3F:Dy3+, Eu3+ phosphors was synthesized by a solid‐state reaction method. The XRD results show that all as‐prepared Ca5(PO4)3F:Dy3+, Eu3+ samples match well with the standard Ca5(PO4)3F structure and the doped Dy3+ and Eu3+ ions have no effect on the crystal structure. Under near‐ultraviolet excitation, Dy3+ doped Ca5(PO4)3F phosphor shows blue (486 nm) and yellow (579 nm) emissions, which correspond to 4F9/2→6H15/2 and 4F9/2→6H13/2 transitions respectively. Eu3+ co‐doped Ca5(PO4)3F:Dy3+ phosphor shows the additional red emission of Eu3+ at 631 nm, and an improved color rendering index. The chromaticity coordinates of Ca5(PO4)3F:Dy3+, Eu3+ phosphors also indicate the excellent warm white emission characteristics and low correlated color temperature. Overall, these results suggest that the Ca5(PO4)3F:Dy3+, Eu3+ phosphors have potential applications in warm white light‐emitting diodes as single‐component phosphor.