bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term effects of xenotransplantation of human enteric glia in immunocompetent rats with brain injury
Authors: Colitti Nina , Rice Edwige , Desmoulin Franck , Combeau Maylis , Parny Mélissa , Robert Lorenne , Buscail Etienne , Bournet Barbara , Vergnolle Nathalie , Raymond-Letron Isabelle , Loubinoux Isabelle , Cirillo Carla 
Published: November 2024

AbstractBackgroundAcute brain injury is characterized by extensive tissue damage, resulting in neuronal loss and functional deficits in patients. The capacity of nerve tissue to self-regenerate is insufficient to repair damaged tissue, thus therapies based on exogenous cells are urgently needed. Human enteric glia (EG) have interesting intrinsic properties that make them a valuable candidate for regenerative medicine. In this long-term study, we investigated whether human EG treatment induces tissue repair and improves functional recovery in a rat model of brain injury.MethodsAcute brain injury was induced by malonate injection in the motor cortex of female rats, causing extensive tissue damage and long-lasting sensorimotor deficits. Human EG were isolated from gut tissue, expanded and administered intranasally in awake immunocompetent rats. To determine the long-term safety and efficacy of human EG treatment, longitudinal evaluation of sensorimotor function,post-mortemtissue regeneration and the fate of human EG were assessed thirty-six weeks after intranasal administration.ResultsTransplanted human EG satisfied the safety criteria, non-immunogenic and non-tumorigenic, required for cell therapy; they were well tolerated in immunocompetent rats, and induced sensorimotor improvement. Importantly, thirty-six weeks post-treatment, intranasally delivered human EG were detected in the rat brain, mainly in the injured motor cortex. This indicated that transplanted human EG migrated and successfully engrafted and integrated with the host tissue. Additionally, human EG induced tissue regeneration by enhancing endogenous angiogenesis and neurogenesis. Notably, thirty-six weeks after administration, human EG generated mature neurons that were enveloped by oligodendrocytes and formed synaptic connections with the host tissue.ConclusionsTransplanted human EG induced tissue repair and showed regenerative potential after brain injury. This is the first study demonstrating the feasibility, safety and efficacy of intranasal administration of human EG for treatment of brain injury.
Macro-financial linkage, endogenous risk premium and monetary policy: evidence from a semi-structural model estimated for Morocco
Authors: Achmakou Lahoucine , Hachimi Alaoui M. El-Hassan 
Published: November 2024

PurposeThis paper seeks to investigate the amplitude of macro-financial linkage for an emerging country like Morocco.Design/methodology/approachFor this purpose, it presents a semi-structural new-Keynesian model. In the blocks of the former, a risk premium is charged on the lending rate in addition to the policy rate. To identify the macro-financial linkage, the risk premium is considered endogenous. It is represented as a function of the borrower’s probability of default, which is, in turn, a function of the GDP gap. To identify this two-wave relationship, we estimate an ARDL model between 2009Q1 and 2020Q1. Therefore, we integrate the estimation results into the new-Keynesian semi-structural model.FindingsThe results reveal a significant impact of the financial condition on the path of the business cycle. In fact, demand shocks and nonperforming loan shocks (NPLs) are exacerbated by the presence of macro-financial linkage. Under this condition, the amplitude and persistence of the shocks are amplified and extended.Originality/valueThis paper extends the literature on the interconnection between the real and financial economies by considering the endogeneity of the credit risk premium and modeling its dynamics.
Impact of ESG ratings on carbon emission reduction performance in context of green development—evidence from Chinese manufacturing listed enterprises
Authors: Yang Fangyi , Guo Jitao , Kong Xiangxin , Wang Chuyi , Wang Zhonghe 
Published: November 2024

PurposeIn the context of green development in China, the circumstance in which Environmental, Social and Governance (ESG) ratings function has changed. As an important external governance mechanism of sustainable development, ESG ratings can also be a two-edged sword for the implementation of carbon emission reduction. This research examines the connection of ESG ratings and corporate carbon emission reduction in the context of green development. This present study postulates that the impact of ESG ratings on carbon emission reduction performance in the context of green development is inverted U-shaped.Design/methodology/approachTo obtain empirical evidence for the hypotheses proposed, this study makes an empirical test based on the two-way fixed effects model. The data is taken from listed Chinese manufacturing firms between 2012 and 2021.FindingsThe study reveals that there is a significant inverted U-shape relationship between ESG ratings and carbon emission reduction performance in the context of green development. Managerial myopic behaviour plays a positive moderating role in the above relationship. In addition, it makes the inflection point of inverted U-shaped curve move to left. Heterogeneity analyses show that the above inverted U-shaped relationship is more significant for firms that don’t hire CEO with environmental protection background or big four accounting firms.Originality/valueIn the background of green development, this study helps to understand dual influence of ESG ratings on corporate carbon emission reduction deeply. It is beneficial to guide enterprises to utilize ESG ratings mechanism reasonably, thus enhancing the effectiveness of carbon emission reduction. This study provides decision-making reference for government to accelerate low-carbon transformation in microcosmic field.
Exploring the factors of learning organization in school education: the role of leadership styles, personal commitment, and organizational culture
Authors: Kareem Jacqueline , Patrick Harold Andrew , Prabakaran Nepoleon 
Published: November 2024

PurposeThis study aims to test the conceptual model of the factors of learning organization and explore the degree of mediation of organizational culture in the relationship between leadership styles, personal commitment, and learning organization in school education.Design/methodology/approachThe learning organization profile (LOP) and OCTAPACE profile served to measure learning organization and organizational culture, respectively. The researchers developed scales to measure principals’ leadership styles and teachers’ personal commitment. Data included 750 school teachers.FindingsThis study found a good fit in the proposed conceptual model. The organizational culture had a significant mediating effect on the path of leadership styles and learning organization and a significant mediating effect on the path of personal commitment and learning organization.Originality/valueTo promote a more comprehensive learning culture, school principals should consider two specific organizational mechanisms: the intangible cultural components (such as corporate values, beliefs, and norms) and the tangible structural components (such as organizational structure and workflow systems). These two domains play a crucial role in creating a conducive learning environment.
An integrated model approach for disaster impact reduction: lessons from a slow onset disaster in Chile
Authors: Gomez-Schwartz David , Castillo-Vergara Mauricio , Contreras González Oscar , Espíndola Arellano Cesar 
Published: November 2024

Purpose
The prolonged drought in Chile’s Coquimbo region has created a permanent state of emergency, forcing the state to spend millions each year distributing drinking water to rural communities. The purpose of this article is to detail a study focused on optimizing the supply of drinking water through trucks in the 15 communes of the region and how the problem was faced in a context of a slowonset disaster.

Design/methodology/approach
A geo-referenced census and optimization analysis of the 5.541 households that receive drinking water was conducted to determine the feasibility of removing trucks from the system. To generate a greater reduction in distribution costs, it was suggested to incorporate water distribution infrastructure projects, changing the concept of ‘expenses’ to ‘investment’.

Findings
The study was born out of the concern for the increased demand for drinking water from rural areas. The proposed and implemented framework allowed an additional 20% reduction in the initial transportation costs; this confirmed the assumption that the proposed optimization model alone would not offer a robust solution and was complemented and integrated with this type of alternative, forming an “integrated model”.

Research limitations/implications
The paper has implications for the resilience of territories affected by climate change.

Practical implications
The methodology can be replicated in other areas where similar interactions occur.

Social implications
Families impacted by drought can improve their quality of life and reduce distress in the face of the constant emergency.

Originality/value
This research aims to contribute knowledge from the perspective of a slow-onset disaster where water resources are scarce. It presents a framework where two disciplines converge, resulting in an “integrated model” that, through its implementation, reduces the costs of resource delivery while simultaneously improving the sanitary conditions of the beneficiary families.
Navigating the digital classroom: a qualitative content analysis of MOOC discourses in Indian e-newspapers
Authors: Lexman Rahul Rajan , Krishnan Gopinath , Baral Rupashree , Thomas Shameem Cina 
Published: November 2024

Purpose
This paper aims to explore and unravel the contents portrayed in online news discourses on massive open online courses (MOOCs). Considering sociological dimensions and journalistic strategies, this study examines how online news media reflects, shapes and informs narratives about the social acceptance and use of the MOOC model of learning.

Design/methodology/approach
Using the Gioia methodology as the overarching framework, this study adopted a two-staged qualitative content analysis of 1,162 online news items from the websites of the top seven online English newspapers of India, published between May 2012 and September 2023. In subsequent semi-structured interviews with subject matter experts, broad themes were identified. In addition, this study integrated Van Dijk’s ideological square model with media content theories to comprehensively analyze the intricate complexities in media depictions of MOOCs.

Findings
While manifest content analysis revealed the emergence of 25 categories, latent content analysis unveiled six broad themes: “announcements, user stages, characteristics, benefits, changing facets, and educational inequalities,” which are associated with the MOOC model. Application of Van Dijk’s model evidenced the usage of a positive self-representation strategy by Indian online news media until mid-2020. The application of media content theories underscored the predominant usage of reframing as a journalistic strategy to maintain reader interest in MOOC-related content in online news items, emphasizing the dynamic nature of media portrayals of social phenomena such as MOOCs.

Practical implications
The depth of MOOC-related coverage and the increasing number of news articles discussing MOOCs in Indian online media signify a growing acceptance of this educational innovation in society. Insights from emergent themes can aid administrators and platforms to effectively design and deliver future courses. In addition, understanding these themes can guide the development of media strategies to address contextual issues such as educational inequalities arising from MOOCs. This study also focuses on the necessity of upholding journalistic ethics in content dissemination.

Originality/value
This study provides a comprehensive synthesis of various themes and journalistic strategies adopted by online news media over the last decade in MOOC-based narratives in India. Given the distinctive Indian context, wherein MOOCs are growing rapidly amid widening digital inequalities, this research addresses calls within information systems literature to explore this phenomenon. It pioneers the integration of communication and mass media theories to analyze the complex sociological dynamics in news discourses on MOOCs, offering a novel perspective on the intersection of media representation and educational innovation.
Driving value and impact through a community of practice: a case study from Australian and Aotearoa New Zealand University libraries
Authors: Hart Simon , Logan Joanna , Wallbutton Alison 
Published: November 2024

PurposeThis study addresses a recognised need in workforce development, a committee of the Council of Australian University Librarians (CAUL) facilitated the establishment of the Value and Impact community of practice (the community) between 2016 and 2017. The aim of this study is to create a structure that allows staff in Australian and Aotearoa New Zealand university libraries to promote best practice and build common capability in planning, performance, evaluation and measurement across a range of activities.Design/methodology/approachMembership is extended to those with roles focusing on quality, standards, analytics, communications or marketing and those with an interest in developing their understanding of these topics. A core group of members play a guardianship role to oversee the operations and liaise with CAUL. In walking the talk, an annual survey gathers performance measures that are reported to CAUL with examples of benefits and shared initiatives. Feedback is used to improve the operations of the community and determine meeting topics. The data and manaakitanga (support and care for each other) have driven these librarians to meet regularly as a community.FindingsMeetings offer a chance for a “round robin” to share practice and trouble shoot or cover a special topic with members or visiting experts presenting and facilitating discussion. At least 75% of the membership consistently report contact with other members outside of the meetings and that the community contributes to building their capability.Originality/valueThe community’s operating template and lessons learnt will be of value to those seeking to build community beyond a one-off professional development engagement.
Strengths and weaknesses of PhD training to develop alternative careers. Insights from PhD holders working beyond academia
Authors: Garcia-Morante Marina , Weise Crista , Diaz Villalba Laura Karina , Castelló Montserrat 
Published: November 2024

Purpose
This study aims to critically assesses how Spanish PhD holders working outside academia perceive and value their past PhD training experiences within academic PhD programs, addressing the growing need for skills applicable in various sectors.

Design/methodology/approach
Using a retrospective interpretative design, the authors collected qualitative data from 35 PhD holders who have transitioned to non-academic careers. Through multimodal interviews, the authors gathered in-depth perceptions to understand the strengths and weaknesses of existing PhD training in relation to non-academic employability.

Findings
The findings highlight a significant disconnect between academic-oriented training and the practical demands of non-academic jobs, particularly in non-research roles. While PhD training was valued in research-related non-academic positions, especially in STEM fields, it was considered insufficient for those in managerial or other non-research roles unless the training included specific industry-related projects. Participants suggested a cultural shift in PhD programs towards a more balanced academic and non-academic focus, integrating societal concerns and broader competencies like effective communication and managerial skills. These changes are seen as crucial for better-preparing PhD candidates for diverse professional environments, emphasising the need for PhD programs to evolve continually in response to the changing dynamics of the labour market and societal needs.

Originality/value
This study contributes to the ongoing discussion about the need for PhD programs to evolve by offering a unique perspective from within the Spanish context. It underscores the necessity for educational reforms incorporating comprehensive skill training, aligning more closely with the career opportunities available to PhD graduates.
Global citizenship, global access, and world-class education: constructing institutional narratives at the Sino-British universities
Authors: Goodbody Felix 
Published: November 2024

Purpose
This study aims to contribute to understandings of how international universities in China construct institutional narratives to attract Chinese students by leveraging themes of global citizenship and international mobility.

Design/methodology/approach
Qualitative analysis of web and other university materials, and mixed-method analysis of social media (WeChat) to identify and quantify recurring themes in the universities’ student-facing presentation.

Findings
Despite differing operational models, both universities emphasize Western education’s prestige and global citizenship, primarily appealing to affluent families and positioning themselves as pathways to international postgraduate study.

Originality/value
The research provides new insights into the student recruitment strategies of international universities in China, contributing to the broader understanding of higher education internationalization in non-Western contexts.
Common Institutional Ownership and Corporate Carbon Emissions
Authors: Qiang Ji , Lei Lei , Wood Geoffrey , Zhang Dayong 
Published: November 2024

AbstractThere has been a growing interest in comparative work exploring when and why firms embark on green paths. It has been concluded that in national contexts where inter‐firm ties are stronger, progress has been stronger. In turn, this raises questions about the impact of inter‐firm ties within, rather than between, national contexts, and in settings where progress towards renewables has been uneven and contested. Accordingly, we explore how common institutional ownership may foster collaboration among firms within the same industry against climate change. Using a sample of US‐listed firms from 2006 to 2019, we obtain robust evidence that firms with industrial peers that are owned by the same institutional investors have lower carbon emissions. In addition, we find that a threshold exists for which the impact on carbon emissions holds only when firms are commonly connected with a substantial number of peers. The existence of this threshold suggests potential free‐riding issues and highlights the beneficial role of investors in promoting cross‐industry collaboration. Overall, our results highlight the role played by institutional investors in tackling climate issues, with important implications for both climate‐ and antitrust‐related regulations.
Secondary findings in 443 exome sequencing data
Authors: Branković Marija , Han Heonjong , Janković Milena , Marjanović Ana , Andrejic Nikola , Gunjić Ilija , Virić Vanja , Palibrk Aleksa , Lee Hane , Peric Stojan 
Published: November 2024

AbstractExome sequencing (ES) may identify and report secondary findings that are unrelated to the primary disease for which the patient underwent genetic testing, but are of potential value in patient care.In this study, we evaluated 81 American College of Medical Genetics (ACMG) medically actionable genes in 443 patients with various neurological disorders. The variants identified were classified and reported following the 2015 ACMG Standards and Guidelines for the interpretation of sequence variants and the ACMG recommendations for reporting secondary findings (v3.2).We detected a total of 17 variants in 17 patients across 9 different genes as secondary findings. Seven heterozygous variants were found in BRCA1, MSH2, and PALB2 which are part of the cancer phenotype category. Nine heterozygous variants were found in MYH7, TTN, LDLR, DSC2, and DSP which are part of the cardiovascular phenotype category. Finally, one heterozygous variant was found in TTR which is part of the miscellaneous phenotype category. Thirteen of above mentioned variants were classified as known pathogenic and four as expected pathogenic.The information collected in our study may lead to the prevention of severe morbidity and mortality and provides additional insight into the genetic background of the Serbian population.
Role of intra‐individual variation in the detection of thresholds for DFI and for misclassification rates: A retrospective analysis of 14,775 SCSA® tests
Authors: Christensen Preben , Fischer Robert , Schulze Wolfgang , Baukloh Vera , Kienast Kimberly , Coull Graham , Parner Erik T. 
Published: November 2024

AbstractBackgroundSperm DNA damage is associated with reduced male fertility after natural conception and intrauterine insemination. However, the impact on in vitro fertilization (IVF) and especially intracytoplasmic sperm injection (ICSI) treatments is still unclear. Few studies have focused on the intra‐individual variation in DFI even though it may have an important role to play in terms of detection of thresholds and for misclassification rates.MethodsResults for Sperm Chromatin Structure Assay (SCSA®) tests performed for 70 European fertility clinics between January 1st, 2008 and December 31st, 2022 were examined. A small retrospective study included 406 couples receiving their first treatment with IVF or ICSI. These results were then used for a mathematical simulation to investigate the role of intra‐individual variation. The large retrospective study included a total of 14,138 diagnostic tests and 637 tests from an IUI study. The distribution of DFI was assessed for the IUI cohort and cohorts of patients attending Sims IVF and Fertility Center Hamburg (FCH). Descriptive analysis of the data was performed regarding time of year, male age, and year.ResultsWhen DFI was above the thresholds of 15 and 25, a significant reduction in ongoing pregnancies after 12 weeks of gestation was observed for IVF and ICSI treatments, respectively. For IVF treatments, the pregnancy rate was reduced from 45.1% to 24.6%, odds ratio = 2.58 (p = 0.004). For ICSI treatments, the pregnancy rate was reduced from 48.6% to 29.6%, odds ratio = 2.00 (p = 0.032). Intra‐individual variation was significantly related to the misclassification rate and the sample size required to identify a threshold. The percentage of patients with a DFI below 15 was 64.8% for the IUI cohort and 51.7% and 41.6% for cohorts of patients attending Sims IVF and FCH, respectively. The median DFI for these cohorts differed significantly and was 11.6, 15.0 and 17.2, respectively. DFI shows a seasonal variation, and increases with male age. During the past 15 years, the median DFI has increased by 0.05% per year (p = 0.02).Discussion and conclusionsOngoing pregnancy rates are reduced significantly for both IVF and ICSI treatments when DFI is above the thresholds of 15 and 25, respectively. The misclassification rate and the required sample size increase with increasing intra‐individual variation. Couples with a DFI above 15 are more likely to experience failed assisted reproductive technology (ART) cycles. DFI appears to have increased during the past 15 years.