bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detecting mosaic patterns in macroevolutionary disparity
Authors: Parins-Fukuchi Caroline 
Published: September 2018

ABSTRACTEvolutionary biologists have long sought to understand the full complexity in pattern and process that shapes organismal diversity. Although phylogenetic comparative methods are often used to reconstruct complex evolutionary dynamics, they are typically limited to a single phenotypic trait. Extensions that accommodate multiple traits lack the ability to partition multidimensional datasets into a set of mosaic suites of evolutionarily linked characters. I introduce a comparative framework that identifies heterogeneity in evolutionary patterns across large datasets of continuous traits. Using a model of continuous trait evolution based on the differential accumulation of disparity across lineages in a phylogeny, the approach algorithmically partitions traits into a set of character suites that best explains the data, where each suite displays a distinct pattern in phylogenetic morphological disparity. When applied to empirical data, the approach revealed a mosaic pattern predicted by developmental biology. The evolutionary distinctiveness of individual suites can be investigated in more detail, either by fitting conventional comparative models or by directly studying the phylogenetic patterns in disparity recovered during the analysis. This framework can supplement existing comparative approaches by inferring the complex, integrated patterns that shape evolution across the body plan from disparate developmental, morphometric, and environmental sources of phenotypic data.
Extended hopanoid loss reduces bacterial motility and surface attachment and leads to heterogeneity in root nodule growth kinetics in a Bradyrhizobium-Aeschynomene symbiosis
Authors: Belin B.J. , Tookmanian E.T , de Anda J. , Wong G. C. L , Newman D.K. 
Published: September 2018

AbstractHopanoids are steroid-like bacterial lipids that enhance membrane rigidity and promote bacterial growth under diverse stresses. Hopanoid biosynthesis genes are conserved in nitrogen-fixing plant symbionts, and we previously found that the extended (C35) class of hopanoids in Bradyrhizobium diazoefficiens are required for efficient symbiotic nitrogen fixation in the tropical legume host Aeschynomene afraspera. Here we demonstrate that the nitrogen fixation defect conferred by extended loss can fully be explained by a reduction in root nodule sizes rather than per-bacteroid nitrogen fixation levels. Using a single-nodule tracking approach to track A. afraspera nodule development, we provide a quantitative model of root nodule development in this host, uncovering both the baseline growth parameters for wild-type nodules and a surprising heterogeneity of extended hopanoid mutant developmental phenotypes. These phenotypes include a delay in root nodule initiation and presence of a subpopulation of nodules with slow growth rates and low final volumes, which are correlated with reduced motility and surface attachment in vitro and lower bacteroid densities in planta, respectively. This work provides a quantitative reference point for understanding the phenotypic diversity of ineffective symbionts in A. afraspera and identifies specific developmental stages affected by extended hopanoid loss for future mechanistic work.
RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation
Authors: Zhou Nan , Uzquiza Alvaro Gutierrez , Zheng Xiang Yu , Vogl Dan , Garfall Alfred L. , Bernabei Luca , Saraf Anita , Florens Laurence , Washburn Michael P. , Illendula Anuradha , Bushweller John H. , Busino Luca 
Published: September 2018

AbstractIkaros family zinc finger protein 1 and 3 (IKZF1 and IKZF3) are transcription factors that promote multiple myeloma (MM) proliferation. The immunomodulatory imide drug (IMiD) lenalidomide promotes myeloma cell death via Cereblon (CRBN)-dependent ubiquitylation and proteasome-dependent degradation of IKZF1 and IKZF3. Although IMiDs have been used as first-line drugs for MM, the overall survival of refractory MM patients remains poor and demands the identification of novel agents to potentiate the therapeutic effect of IMiDs. Using an unbiased screen based on mass spectrometry, we identified the Runt-related transcription factor 1 and 3 (RUNX1 and RUNX3) as interactors of IKZF1 and IKZF3. Interaction with RUNX1 and RUNX3 inhibits CRBN-dependent binding, ubiquitylation and degradation of IKZF1 and IKZF3 upon lenalidomide treatment. Inhibition of RUNXs, via genetic ablation or a small molecule (AI-10-104), results in sensitization of myeloma cell lines and primary tumors to lenalidomide. Thus, RUNX inhibition represents a valuable therapeutic opportunity to potentiate IMiDs therapy for the treatment of multiple myeloma.
De novoassembly, delivery and expression of a 101 kb human gene in mouse cells
Authors: Mitchell Leslie A. , McCulloch Laura H. , Pinglay Sudarshan , Berger Henri , Bosco Nazario , Brosh Ran , Bulajic Milica , Huang Emily , Hogan Megan S. , Martin James A. , Mazzoni Esteban O. , Davoli Teresa , Maurano Matthew T. , Boeke Jef D. 
Published: September 2018

AbstractDesign and large-scale synthesis of DNA has been applied to the functional study of viral and microbial genomes. New and expanded technology development is required to unlock the transformative potential of such bottom-up approaches to the study of larger mammalian genomes. Two major challenges include assembling and delivering long DNA sequences. Here we describe a pipeline forde novoDNA assembly and delivery that enables functional evaluation of mammalian genes on the length scale of 100 kb. The DNA assembly step is supported by an integrated robotic workcell. We assembled the 101 kb humanHPRT1gene in yeast, delivered it to mouse embryonic stem cells, and showed expression of the human protein from its full-length gene. This pipeline provides a framework for producing systematic, designer variants of any mammalian gene locus for functional evaluation in cells.Significance StatementMammalian genomes consist of a tiny proportion of relatively well-characterized coding regions and vast swaths of poorly characterized “dark matter” containing critical but much less well-defined regulatory sequences. Given the dominant role of noncoding DNA in common human diseases and traits, the interconnectivity of regulatory elements, and the importance of genomic context,de novodesign, assembly, and delivery can enable large-scale manipulation of these elements on a locus scale. Here we outline a pipeline forde novoassembly, delivery and expression of mammalian genes replete with native regulatory sequences. We expect this pipeline will be useful for dissecting the function of non-coding sequence variation in mammalian genomes.
New method for runoff estimation under different soil management practices
Authors: Bashagakule Janvier Bigabwa , Logah Vincent , Opoku Andrews , Tuffour Henry Oppong , Sarkodie-Addo Joseph , Quansah Charles 
Published: September 2018

AbstractSoil erosion has been widely measured using different approaches based on models, direct runoff and sediment collections. However, most of the methods are, poorly applied due to the cost, the accuracy and their tedious nature. This study aimed to develop and test a new method for runoff characterization, which may be more applicable and adaptable to different situations of soil and crop management. An experiment was carried out on runoff plots under different cropping systems (sole maize, sole soybean and maize intercropped with soybean) and soil amendments (NPK, Biochar, NPK + Biochar and Control) in the Semi-deciduous forest zone of Ghana. The study was a two-factor experiment (split-plot) in which cropping systems constituted the main plot whereas soil management the subplot. To assess the quality of the method, different statistical parameters were used: p-values, coefficient of determination (R2), Nash-Sutcliffe efficiency (NSE), root mean square (RMSE) and, root square ratio (RSR). The NPK + Biochar under each cropping system reduced surface runoff than all other treatments. At p < 0.001, R2 ranged from 0.88 to 0.94 which showed good accuracy of the method developed. The dispersion between the predicted and observed values was low with RMSE varying from 1.68 to 2.66 mm which was less than 10 % of the general mean of the runoff. Moreover, the low variability between parameters was confirmed by the low values of RSR ranging from 0.38 to 0.46 (with 0.00 ≤ RSR ≤ 0.50 for perfect prediction). NSE values varied from 0.79 to 0.86 (≥0.75 being the threshold for excellent prediction). Though the sensitivity analysis showed that the method under high amount of runoff (especially on bare plots) was poorly adapted, the dimensions of runoff plots could be based on runoff coefficient of the region by analyzing the possible limits of an individual rainfall amount of the site. The findings provide alternative approach for monitoring soil degradation.
The location of comprehensive income reporting – does it pass the financial analyst revision test?
Authors: Banks Louis , Hodgson Allan , Russell Mark 
Published: September 2018

Purpose
This paper aims to test whether a change in the reporting location of income, and other comprehensive income (OCI) components, in a statement of comprehensive income (SoCI) under International Financial Reporting Standards affects their value-relevance and use by financial analysts.

Design/methodology/approach
The study tests the associations between CI, OCI, share returns and financial analyst forecast revisions.

Findings
Results show that comprehensive income is less value-relevant than net income, regardless of reporting location. Changing the reporting location of OCI components to the SoCI does not provide incremental improvement for financial analysts or stock prices. Finally, the paper finds that analysts use OCI components to revise forecasts.

Originality/value
The paper addresses the question of which OCI components should be reported, and the importance of reporting location. The paper extends the examination of OCI components to financial analysts as expert financial report users.
Overlapping membership on audit and compensation committees, equity holdings of overlapping members and audit outcomes
Authors: Habib Ahsan , Bhuiyan Md. Borhan Uddin 
Published: September 2018

PurposeThis paper aims to examine the question of whether external auditors incorporate equity holdings by overlapping audit committee members as a priced governance factor and tests whether this attribute, as a mechanism for ensuring good governance, affects the propensity for external auditors to issue modified audit opinions.Design/methodology/approachOverlapping membership in this context refers to the arrangement where at least one audit committee member also sits on the compensation committee. Both ordinarily least square and logistic regression are used to capture the impact of overlapping committee members and equity holding of those overlapping committee members.FindingsUsing archival data from Australian Stock Exchange listed companies, the authors find support for the beneficial effect of having overlapping audit committee members with equity holdings. The authors also find that auditor propensity to issue modified audit opinions is lower for firms with equity holdings by overlapping audit committee members.Practical implicationsThe finding has practical implication to the investors and regulators as overlapping audit committee members with equity holdings may provide especially effective oversight by monitoring opportunistic accounting policy choices for maximizing compensation pay. To the extent that this occurs, audit risk will decrease, requiring less audit effort and lower audit fees than would otherwise be necessary. Similarly, such oversight is likely to make financial reporting more credible and will reduce the possibility of receiving modified audit opinions by reporting organizations.Originality/valueBoth audit and compensation committees are equally important in modern organizations. While both of the committee have distinctive responsibilities, questions remain on the desirability of overlapping audit committee. Also, this is the first study to the authors’ knowledge that incorporates overlapping membership on audit and compensation committee as an important component of auditor risk perception which regards in pricing the audit fees.
Local responses to disasters: recent lessons from zero-order responders
Authors: Briones Fernando , Vachon Ryan , Glantz Michael 
Published: September 2018

Purpose
The purpose of this paper is to define and discuss the concept of zero-order responders (ZOR). It explores the potential lessons and the additive value that assimilation of responses of disaster-affected people into disaster risk reduction (DRR) and disaster risk management (DRM) programs can provide.

Design/methodology/approach
In order to support this concept, the authors review two recent extreme hydrometeorological events, illustrating how local populations cope with disasters during the period before external support arrives. Additionally, the authors address their under-leveraged role in the management of recovery. The empirical evidence was collected by direct observations during the 2017 El Niño Costero-related floods in Peru, and by the review of press following 2017 hurricanes Irma and Maria destruction in Puerto Rico.

Findings
During disasters, there is a window of time before official and/or external support arrives. During this period, citizens must act unsupported by first responders – devising self-coping strategies in order to survive. In the days, weeks and months following a disaster, local populations are still facing recovery with creativity.

Research limitations/implications
Citing references arguing for or against the value of documenting survivor methods to serve as a testimony for the improvement of DRR programming.

Practical implications
DRR and DRM must integrate local populations and knowledge into DRR planning to improve partnerships between communities and organizations.

Social implications
The actions and experiences of citizens pro-acting to pave fruitful futures is a valuable commentary on improvements for DRR and management.

Originality/value
This paper proposes a citizen-centered contribution to future disaster risk reducing actions. This approach emphasizes the reinterpretation of local responses to disasters. DRRs and DRMs growth as fields would value from heralding ZOR coping and improvisation skills, illustrated under stressful disaster-related conditions, as an additive resource to programming development.
Connecting the poor: the internet, mobile phones and financial inclusion in Africa
Authors: Evans Olaniyi 
Published: September 2018

Purpose
The increased adoption of internet-enabled phones in Africa has caused much speculation and optimism concerning its effects on financial inclusion. Policymakers, the media and various studies have all flaunted the potentials of internet and mobile phones for financial inclusion. An important question therefore is “Can the internet and mobile phones spur the inclusion of the financially excluded poor? This study therefore aims to examine the relationship and causality between internet, mobile phones and financial inclusion in Africa for the 2000-2016 period.

Design/methodology/approach
The empirical analysis followed these three steps: examination of the stationarity of the variables; testing for the cointegration; and evaluation of the effects of the internet and mobile phones on financial inclusion in Africa for the 2000-2016 period using three outcomes of panel FMOLS approach and Granger causality tests.

Findings
The empirical evidence shows that internet and mobile phones have significant positive relationship with financial inclusion, meaning that rising levels of internet and mobile phones are associated with increased financial inclusion. There is also uni-directional causality from internet and mobile phones to financial inclusion, implying that internet and mobile phones cause financial inclusion. The study also shows that macroeconomic factors such as capital formation, primary enrollment, bank credit, broad money, population growth, remittances, agriculture and interest rate, as well as institutional factors such as regulatory quality are important underlying factors for financial inclusion in Africa.

Originality/value
In the literature, there is a dearth of research on the internet, mobile phones and financial inclusion, especially in Africa. Most of the related studies are conceptual and micro-based, with little empirical attention to the relationship and causality between internet, mobile phones and financial inclusion. In fact, this dearth of rigorous empirical studies has been attributed as the main cause of inadequate policy guidance in enhancing information communication technologies (Roycroft and Anantho, 2003), despite saturation levels in developed economies. This study fills the gap by evaluating the effects of the Internet and mobile phones on financial inclusion for 44 African countries for the 2000-2016 period.
Livestreaming vs pre-recorded
Authors: Ang Tyson , Wei Shuqin , Anaza Nwamaka A. 
Published: September 2018

PurposeMarketing researchers currently lack a systematic and empirical understanding of digital social viewing strategies. Drawing on social impact theory, this study aims to investigate if and how firm-initiated digital social viewing strategies (livestreaming vs pre-recorded) influence consumer viewing experiences and consequential behavioral intentions.Design/methodology/approachA scenario-based experiment was conducted with 462 participants. The study involved social viewing strategies in a new product launch context. Data were analyzed using structural equation modeling.FindingsThis study demonstrates that social influence cues (social presence and synchronicity) inherent in a livestreaming strategy induce a more authentic consumer viewing experience than a pre-recorded strategy, which in turn increases consumers’ searching and subscribing intention. However, a company’s social viewing strategy does not moderate the effect of search and subscribe intention on purchase intention.Research limitations/implicationsThis study extends the application of social impact theory by showing that social presence and synchronicity impact authentic consumer viewing experiences, which influence consumers’ searching, subscribing and purchasing intention.Practical implicationsThis study validates the importance of using social viewing as a viable digital marketing strategy for practitioners. The paper provides marketers ways to increase consumer purchase intention via livestreaming marketing content, particularly for new products.Originality/valueThis study extends the traditional research on social viewing into the realm of digital social viewing. It is among the first to delineate the advantages of both livestreaming and pre-recorded social viewing approaches.
The influence of thermal radiation on unsteady free convection in inclined enclosures filled by a nanofluid with sinusoidal boundary conditions
Authors: Sheremet Mikhail A. , Pop Ioan , Rosca Alin V. 
Published: September 2018

Purpose
The purpose of this study is a numerical analysis of transient natural convection in an inclined square cavity filled with an alumina-water nanofluid under the effects of sinusoidal wall temperature and thermal radiation by using a single-phase nanofluid model with empirical correlations for effective viscosity and thermal conductivity.

Design/methodology/approach
The domain of interest includes the nanofluid-filled cavity with a sinusoidal temperature distribution along the left vertical wall. Horizontal walls are supposed to be adiabatic, while right vertical wall is kept at constant low temperature. Temperature of left wall varies sinusoidally along y-coordinate. It is assumed in the analysis that the thermophysical properties of the fluid are independent of temperature and the flow is laminar. The governing equations have been discretized using the finite difference method with the uniform grid. Simulations have been carried out for different values of the Rayleigh number, cavity inclination angle, nanoparticles volume fraction and radiation parameter.

Findings
It has been found that a growth of radiation parameter leads to the heat transfer enhancement and convective flow intensification. At the same time, an inclusion of nanoparticles illustrates a reduction in the average Nusselt number and fluid flow rate.

Originality/value
The originality of this work is to analyze unsteady natural convection in a square cavity filled with a water-based nanofluid in the presence of a sinusoidal temperature distribution along one wall. The results would benefit scientists and engineers to become familiar with the analysis of convective heat and mass transfer in nanofluids and the way to predict the properties of nanofluid convective flow in advanced technical systems, in industrial sectors including transportation, power generation, chemical sectors, electronics, etc.
Disability and social cohesion among older adults: a multi-country study
Authors: Rahman Mohammad Hifz Ur , Singh Ashish 
Published: September 2018

PurposeDisabled are often vulnerable to social exclusion due to the lack of social protection schemes. Therefore, in the absence of adequate social welfare systems, social cohesion is of enormous importance for the disabled older adults. That said, the purpose of this paper is to explore the link between disability and social cohesion among the older adults in China, Ghana, India, Mexico, Russia and South Africa.Design/methodology/approachData from the Study on Global Ageing and Adult Health (SAGE) conducted in China, Ghana, India, Mexico, Russia and South Africa during 2007–2010 have been used for the analysis. Disability scores and social cohesion scores have been constructed using the Item Response Theory Partial Credit Model. Also, bivariate, multivariate and path analyses have been used for the examination.FindingsResults show that disability substantially and significantly restricts social cohesion of the older adults in the selected countries. Moreover, path analysis indicates that, among others, disability affects physical activity which, in turn, leads to a lower socially active life. In addition, social cohesion is significantly lower among the older adults who are females, residing in urban areas, in poorer classes, widowed, not working and not having formal education.Originality/valueTo the best of the authors’ search, this study is perhaps the first attempt to look into the association between disability and social cohesion in a comprehensive and holistic manner in a multi-country context. A socially cohesive society provides a sense of belonging, participation, inclusion, and recognition to all. So, it is high time to create a socially as well as economically sensitive environment which can provide due recognition and inclusion to the disabled older adults.