bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a predictive model for the efficacy of ropivacaine lumbar-square muscle block for analgesia after cesarean delivery
Authors: Zhang Yaoyao , Li Jiawei , Feng Kaidi , Yuan Yingchuan , Wang Denglan 
Published: November 2024

Abstract
Background
Effective postoperative analgesia is essential in the clinical management of cesarean sections, with the lumbar square muscle block (Quadratus Lumborum Block, QLB) recognized as a viable analgesic option. Nonetheless, the development of a predictive model for its analgesic efficacy postoperatively remains underexplored.

Objective
This study aims to establish a predictive model for the postoperative analgesic effects of QLB through retrospective analysis, thereby offering a scientific foundation for clinical practice.

Methods
A total of 338 patients who underwent cesarean sections under intrathecal anesthesia, accompanied by QLB, at the Second Affiliated Hospital of Xinjiang Medical University from February 2018 to December 2023 were included in this analysis. The predictive model was developed utilizing univariate analysis, Lasso regression, and multifactorial logistic regression analysis, with validation conducted through Receiver Operating Characteristic (ROC) curves, calibration curves, and the Hosmer–Lemeshow test.

Results
The model demonstrated high accuracy and calibration.

Conclusion
The predictive model developed in this study holds significant potential for early assessment of the analgesic effects of QLB, thereby equipping clinicians with a scientifically grounded and precise tool for pain management.
Serious mental health conditions and exposure to adulthood trauma in low- and middle-income countries: a scoping review
Authors: Stevenson Anne , Girma Engida , Kitafuna Benon Kabale , Harerimana Boniface , Koenen Karestan C. , Seedat Soraya 
Published: November 2024

Abstract

Background
There is a strong link between trauma exposure and serious mental health conditions (SMHCs), such as schizophrenia and bipolar disorder. The majority of research in the field has focused on childhood trauma as a risk factor for developing an SMHC and on samples from high-income countries. There is less research on having an SMHC as a risk factor for exposure to traumatic events, and particularly on populations in low- and middle-income countries (LMICs).
This scoping review aimed to synthesize the nature and extent of research on traumatic events that adults with SMHCs face in LMICs. It was conducted across five databases: PubMed, Embase, PsycINFO, Web of Science Core Collection and Africa-Wide Information/NiPad in December 2023 and by hand searching citation lists.

Findings
The database search returned 4,111 articles. After removing duplicates and following a rigorous screening process, 51 articles met criteria for inclusion. There was one case study, one mixed methods study, 12 qualitative studies and 37 quantitative studies. Ten countries were represented, with the most studies from India (n = 19), Ethiopia (n = 9) and China (n = 6). Schizophrenia was the most studied type of SMHC. Of the trauma exposures, more than 76% were on interpersonal violence, such as sexual and physical violence. Of the studies on interpersonal violence, more than 23% were on physical restraint (e.g., shackling) in the community or in hospital settings. There were no studies on man-made or natural disasters.

Implications
Much of our data in this population are informed by a small subset of countries and by certain types of interpersonal violence. Future research should aim to expand to additional countries in LMICs. Additional qualitative research would likely identify and contextualize other trauma types among adults with SMHCs in LMICs.
Phelan-McDermid syndrome-associated psychosis: a systematic review
Authors: Colijn Mark A. 
Published: November 2024

Abstract

Objective:
Phelan-McDermid syndrome is a rare genetic disorder characterised by various neurodevelopmental, medical, and psychiatric issues. Although bipolar disorder-like presentations and catatonia are particularly common, psychosis has also been reported but is less well described. As such, this systematic review sought to characterise the phenomenology of psychosis in Phelan-McDermid syndrome, clarify the association of psychotic symptoms with other neuropsychiatric features of the disorder, and describe antipsychotic treatment response.

Methods:
A literature search was completed in July 2024 using PubMed and Scopus. Only English-language articles that reported the occurrence of psychotic symptoms in Phelan-McDermid syndrome were eligible for inclusion. 18 articles describing 35 individuals were included in the main analyses. Three additional articles of relevance are discussed separately, as they either provided limited clinical information or did not present data in a patient-specific manner.

Results:
The average age of psychosis onset was ∼17 years, and 65% of individuals developed symptoms at or before age 15. ∼69% of individuals also experienced catatonia, ∼81% experienced mood symptoms, and 50% experienced both. Visual hallucinations were the most commonly reported psychotic symptom. Where reported, ∼76% of individuals exhibited at least a partial and/or temporary response to antipsychotic therapy.

Conclusion:
Psychotic presentations in Phelan-McDermid syndrome may qualitatively differ from schizophrenia. Although numerous antipsychotics may be efficacious in the treatment of Phelan-McDermid syndrome-associated psychosis, this review most importantly highlights the paucity of available high-quality evidence to guide treatment decisions in this respect, and as such indicates the need for more reports to be published.
Exercise combined with vitamin D supplementation has additive health effects on short physical performance battery and stair climbing in older adults: a scope review of randomised controlled trials
Authors: Zhang Jinghua , Zhu Zheng , Niu YanJun , Cao Zhen-Bo 
Published: November 2024

AbstractThis scoping review aimed to evaluate the effect of exercise combined with vitamin D supplementation on skeletal muscle health in older individuals. We implemented a systematic search of electronic databases, including PubMed, the Cochrane Library, Web of Science and Embase, which was conducted from the time of library construction to January 2024. Eligible studies were randomised controlled trials including men and women aged ≥ 65 years or mean age ≥ 65 years; exercise training and vitamin D supplementation; outcomes of muscular strength, function, muscular power, body composition and quality of life; and results compared with those of exercise intervention alone. The results showed thirteen studies including 1483 participants were identified. The proportions of male and female sex were 22·05 and 77·95 %, respectively. Exercise intervention methods included resistance exercises and multimodal exercise training. All vitamin D interventions involved supplementation with vitamin D3. A significant increase was identified in short physical performance battery and stair climbing but not in skeletal muscle mass, skeletal strength, the timed up and go test and gait speed in older adults after exercise combined with vitamin D supplementation. In conclusion, exercise combined with vitamin D supplementation has additive health effects on short physical performance battery and stair climbing. Furthermore, when vitamin D was deficient at baseline, the combined effect of exercise and vitamin D intervention significantly increased the timed up and go test and gait speed in older adults. In future randomised controlled trials on this topic, baseline vitamin D nutritional status, health condition and sex should be considered.
Concentration, motivation, activity, and subjective fatigue in patients with single-sided deafness
Authors: Gürses Emre , Kılıç Samet , Çıldır Bünyamin 
Published: November 2024

AbstractObjectiveTo evaluate four dimensions of fatigue, including subjective fatigue severity, concentration problems, reduced motivation, and activity in patients with single-sided deafness.MethodsFollowing audiological assessment, the Checklist Individual Strength scale and Montreal Cognitive Assessment were performed on 41 adults with single-sided deafness and 41 sex-matched adults with normal bilateral hearing in the study group and control group, respectively. Subjective fatigue severity, concentration, motivation, activity level and cognitive performance were analysed between and within groups.ResultsIndividuals with single-sided deafness exhibited reduced concentration and motivation; however, their activity level was average. Subjective fatigue symptoms were more prevalent in individuals with single-sided deafness than in control participants. The concentration problem was related to decreased cognitive performance.ConclusionThis study revealed negative somatic consequences of single-sided deafness. Self-perceived fatigue is likely underestimated in this population due to the limited studies reported in the literature. Further studies should focus on counselling, follow up and hearing rehabilitation concerning ameliorating fatigue.
Effects of time-restricted eating on body composition, biomarkers of metabolism, inflammation, circadian system and oxidative stress in overweight and obesity: an exploratory review
Authors: Lages Marlene , Carmo-Silva Sara , Barros Renata , Guarino Maria Pedro 
Published: November 2024

Abstract
Obesity is a chronic, complex and multi-factorial condition with an increasing prevalence worldwide. Irregular eating schedules might be a contributing factor to these numbers through the dysregulation of the circadian system. Time-restricted eating (TRE), an approach that limits eating windows, has been studied as a strategy to treat obesity, aligning eating occasions with metabolic circadian rhythms. This review aims to provide an overview of the impact of TRE protocols on metabolic, inflammatory, oxidative stress and circadian rhythm biomarkers in people with overweight or obesity. Most studies report significant weight loss following TRE protocols. While glucose levels decreased in nearly all TRE interventions, only a few studies demonstrated statistically significant differences when compared to the control groups. The findings for c-reactive protein and TNF-α were inconsistent, with limited significant differences. Changes in lipid profile changes were variable and generally did not reach statistical significance. Both 4-hour and 6-hour TRE interventions significantly reduced 8-isoprostane levels. Additionally, TRE significantly altered clock gene expression, as well as that of genes associated with metabolic regulation in subcutaneous adipose tissue. While the evidence is still inconsistent, limiting eating to a consistent daily window of 8 to 12 h can improve insulin sensitivity, reduce blood glucose, cholesterol and triglyceride levels and promote weight loss. These effects are likely attributable to both direct metabolic impacts and indirect benefits from weight loss and improved dietary habits. However, data on circadian, inflammatory and specific metabolic biomarkers remain scarce and occasionally contradictory, highlighting the need for further research on these interventions.
Haemoparasite infection risk in multi-host avian system: an integrated analysis
Authors: Podmokła Edyta , Dubiec Anna , Pluciński Bartosz , Zając Bartłomiej , Gustafsson Lars 
Published: November 2024

Abstract
Avian blood parasites play a crucial role in wildlife health and ecosystem dynamics, exhibiting heterogeneous spatial distribution influenced by various factors. Although factors underlying heterogeneity in infection with blood parasites have been explored in many avian hosts, their importance in the context of host species and the parasite taxon remains poorly understood, particularly in cohabiting host species. Using next-generation sequencing for parasite screening, we investigate the association between Haemoproteus, Plasmodium and Trypanosoma infections in relation to individual parameters, host densities and landscape features in 3 cavity-nesting passerines: great tit (Parus major), blue tit (Cyanistes caeruleus) and collared flycatcher (Ficedula albicollis) in a highly fragmented forest habitat. Overall, Haemoproteus infections predominated, followed by Plasmodium and Trypanosoma, with great tits most and collared flycatchers least parasitized. There were no common patterns across host species in the probability of infection with locally transmitted parasites from each genus. Specifically, in all cases, the effect of particular parameters, if present, was observed only in 1 host species. Body condition influenced Haemoproteus and Plasmodium infections differently in tits. Host density, whether own species or all pooled, explained Haemoproteus infections in great tits and collared flycatchers, and Plasmodium in great tits. Landscape metrics, such as moisture index and distance to coast edge and pastures, affected infection probability in specific host–parasite combinations. Relative risk maps revealed infection risk gradients, but spatial variation repeatability over time was low. Our study highlights the complex dynamics of avian blood parasites in multi-host systems, shedding light on host–parasite interactions in natural ecosystems.
Taxonomy and systematics of Emprostiotrema Cianferoni and Ceccolini, 2021 (Digenea: Emprostiotrematidae), parasites of rabbitfish (Siganidae) from the Indo-West Pacific marine region
Authors: Huston Daniel C. , Cutmore Scott C. , Cribb Thomas H. , Sasal Pierre , Yong Russell Q.-Y. 
Published: November 2024

Abstract
Emprostiotrema contains just 3 species: E. fusum, E. kuntzi and E. sigani. As adults, all 3 species infect rabbitfishes (Siganidae: Siganus). New collections from 11 species of Siganus from northern Australia, Indonesia, New Caledonia, French Polynesia, Palau and Japan enabled an exploration of species composition within this genus. Phylogenetic analyses demonstrate a deep distinction between 2 major clades; clade 1 comprises most of the sequences of specimens from Australia as well as all of those from Japan, Palau and New Caledonia and clade 2 comprises all sequences of specimens from French Polynesia, 2 sequences from Australia and the single sequence from Bali. In all analyses, both major clades have genetic structuring leading to distinct geographic lineages. Morphologically, specimens relating to clades 1 and 2 differ but overlap in body shape, oral sucker and egg size. Principle component analysis shows a general (but not complete) separation between specimens relating to the 2 clades. We interpret the 2 clades as representing 2 species: clade 1 is identified as E. fusum and is reported in this study from 10 species of siganids from Australia, Japan, Palau and New Caledonia; clade 2 is described as E. gotozakiorum n. sp., for all specimens from French Polynesia and rare specimens from Australia and Indonesia. We recognize E. sigani as a junior synonym of E. fusum. Although species of Emprostiotrema occur widely in the tropical Indo-Pacific, they have not been detected from Ningaloo Reef (Western Australia), the southern Great Barrier Reef or Moreton Bay (southern Queensland).
Examining the mental health trajectories of children and adolescents: a cross-cohort analysis
Authors: McNicholas Fiona , Gavin Blanaid , Sellers Ruth , Ji Iris , Zhang Xiaoning , Browne Wendy V , Harold Gordon 
Published: November 2024

AbstractBackgroundEpidemiological samples provide opportunity to understand the development of mental health trajectories to better understand whether such epidemiological data can help to plan and modify service delivery for youth mental health. Variation between countries is not well understood and thus applying evidence from other countries to national strategies limits support service policy and planning. We therefore examine developmental patterns of youth mental health across different countries using the Growing Up in Ireland (GUI) Cohorts, with comparison to existing UK longitudinal cohort data (Millennium Cohort Study, MCS; Growing up in Scotland, GUS).MethodsYouth mental health problems within each cohort across development (5–17/18 years) were assessed using parent reported Strengths and Difficulties Questionnaire (SDQ) scores. Using latent growth curve analyses, we examined trajectories of emotional, conduct, and hyperactivity problems for boys and girls, separately for each cohort.ResultsAcross cohorts, we observed similar developmental patterns for emotional, conduct, and hyperactivity problems. However, the GUI emotional problems in Ireland emerged earlier than in the UK. By adolescence, GUI emotional scores were similar to the UK, suggesting that the differences in emotional problems between the ROI and UK had narrowed by adolescence. Covariates also had different associations with youth mental health trajectories across cohorts.ConclusionsUtilizing multiple nationally representative cohort longitudinal datasets can help inform clinically meaningful conclusions and potential recommendations on population level multi-tiered service needs and development in the area of child and adolescent mental health support and future provision.
Ketamine for the Treatment of Psychiatric Disorders: A Systematic Review and Meta-Analysis
Authors: Kwan Angela T.H. , Lakhani Moiz , Singh Gurkaran , Le Gia Han , Wong Sabrina , Teopiz Kayla M. , Dev Donovan A. , Manku Arshpreet Singh , Sidhu Gurnoor , McIntyre Roger S. 
Published: November 2024

AbstractBackgroundInadequate response to first- and second-line pharmacological treatments for psychiatric disorders is commonly observed. Ketamine has demonstrated efficacy in treating adults with treatment-resistant depression (TRD), with additional off-label benefits reported for various psychiatric disorders. Herein, we performed a systematic review and meta-analysis to examine the therapeutic applications of ketamine across multiple mental disorders, excluding mood disorders.MethodsWe conducted a multidatabase literature search of randomized controlled trials and open-label trials investigating the therapeutic use of ketamine in treating mental disorders. Studies utilizing the same psychological assessments for a given disorder were pooled using the generic inverse variance method to generate a pooled estimated mean difference.ResultsThe search in OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), EBSCO CINAHL Plus, Scopus, and Web of Science yielded 44 studies. Ketamine had a statistically significant effect on PTSD Checklist for DSM-5 (PCL-5) scores (pooled estimate = ‒28.07, 95% CI = [‒40.05, ‒16.11], p < 0.001), Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) scores (pooled estimate = ‒14.07, 95% CI = [‒26.24, ‒1.90], p = 0.023), and Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores (pooled estimate = ‒8.08, 95% CI = [‒13.64, ‒2.52], p = 0.004) in individuals with PTSD, treatment-resistant PTSD (TR-PTSD), and obsessive compulsive disorder (OCD), respectively. For alcohol use disorders and at-risk drinking, there was disproportionate reporting of decreased urge to drink, increased rate of abstinence, and longer time to relapse following ketamine treatment.ConclusionsExtant literature supports the potential use of ketamine for the treatment of PTSD, OCD, and alcohol use disorders with significant improvement of patient symptoms. However, the limited number of randomized controlled trials underscores the need to further investigate the short- and long-term benefits and risks of ketamine for the treatment of psychiatric disorders.
Ayahuasca: pharmacology, safety, and therapeutic effects
Authors: dos Santos Rafael Guimarães , Hallak Jaime Eduardo Cecilio 
Published: November 2024

Abstract
Ayahuasca is a botanical hallucinogen traditionally used for therapeutic and ritual purposes by indigenous groups from Northwestern Amazonian countries such as Brazil, Peru, Colombia, and Ecuador. Ayahuasca is made by the decoction of two plants, which are rich in the 5-HT1A/2A partial agonist dimethyltryptamine or DMT (from the leaves of the Psychotria viridis bush) and β-carbolines such as harmine, from the stalks of the Banisteriopsis caapi vine. There is an increasing interest in the possible therapeutic effects of ayahuasca, especially for psychiatric disorders (major depression, posttraumatic stress disorder, and substance use disorder). This review summarizes information on the pharmacology, safety, and therapeutic potentials of ayahuasca. Although human experimental and naturalist studies published until now suggest a good safety and tolerability profile, often associated with improvements in depressive and anxious symptoms, there are few controlled studies, with small sample sizes, using only single doses, and with short follow-ups. Potential benefits of ayahuasca should be evaluated in larger samples in both experimental and observational studies and using different doses in controlled trials.
The impact of COVID-19 on referrals among general practitioners and specialists in Shanghai, China
Authors: Xu Zhongqing , Fan Jingchun , Shi Dandan , Ding Jingjing , Zhou Jun , Feng Xianzhen , Hambly Brett D. , Tao Kun , Bao Shisan 
Published: November 2024

Abstract

Background:
The COVID-19 pandemic has impacted patient’s visits to general practitioners (GPs). However, it is unclear what the impact of COVID-19 has been on the interaction among the local primary care clinics, the GP Department within the hospital and specialists.

Methods:
The interaction among GPs referring to hospital-based specialists and specialists to local doctors was determined, comparing pre-pandemic 2019 and 2020 during the pandemic.

Results:
Reduced referrals from GPs to specialists were consistent with the reduction in specialist referrals back to the local doctors, which dropped by approximately 50% in 2020, particularly in the two most common chronic conditions (hypertension and diabetes mellitus).

Discussion:
Reduced referral of patients from local clinics to Tongren Hospital is probably due to the extensive online training provided to the local GPs to become more competent in handling local patients via telehealth. Our data provide some insight to assist in combatting the pandemic of COVID-19, offering objective evidence of the impact of COVID-19 on patient management by GPs.
Stigma in Mexican patients with Lung Cancer: Psychometric Properties of the Cataldo Lung Cancer Stigma Scale (CLCSS) - Brief version
Authors: Flores-Juárez Joel , Galindo-Vázquez Oscar , Ortega-Andeane Patricia , Fresán-Orellana Ana , Montero-Pardo Xolyanetzin , Estapé Tania , Arroyo-Hernández Marisol , Cabrera-Miranda Luis Antonio , Arrieta Oscar 
Published: November 2024

AbstractIntroductionStigma in lung cancer patients may be associated with various negative outcomes such as increased psychosocial symptoms, severity of physical symptoms, and may act as a barrier to medical help-seeking behavior. The Cataldo Lung Cancer Stigma Scale (CLCSS) is one of the most widely used instruments for assessing health-related stigma in lung cancer patients.ObjectivesTo determine the psychometric properties of the CLCSS in a Mexican sample of lung cancer patients.MethodsA non-experimental, instrumental design was employed, using non-probabilistic sampling based on availability. The sample included 265 lung cancer patients. Confirmatory Factor Analysis (CFA) was conducted to assess construct validity, and Cronbach’s alpha and McDonald’s Omega were used for internal consistency and test-retest reliability, respectively, through Pearson correlation coefficient.ResultsThe 17-item version yielded a model with 4 factors (stigma and shame, social isolation, discrimination, and smoking) explaining 50.74% of the variance, with adequate values of internal consistency and test-retest reliability.Significance of resultsThe Mexican version of the CLCSS is culturally appropriate, brief, psychometrically valid, and reliable for assessing health-related stigma in Mexican lung cancer patients.