bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining the prevalence and symptom burden of those with self-reported severe chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a two-phase community pilot study in the North East of England
Authors: Strassheim Victoria Jane , Sunnquist Madison , Jason Leonard A , Newton Julia L 
Published: September 2018

ObjectivesTo define the prevalence of severe chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and its clinical characteristics in a geographically defined area of Northern England. To understand the feasibility of a community-based research study in the severely affected CFS/ME group.DesignA two-phase clinical cohort study to pilot a series of investigations in participants own homes.SettingParticipants were community living from the area defined by the Northern clinical network of the UK.ParticipantsAdults with either a medical or a self-reported diagnosis of CFS/ME. Phase 1 involved the creation of a database. Phase 2: five participants were selected from database, dependent on their proximity to Newcastle.InterventionsThe De Paul fatigue questionnaire itemised symptoms of CFS/ME, the Barthel Functional Outcome Measure and demographic questions were collected via postal return. For phase 2, five participants were subsequently invited to participate in the pilot study.Results483 questionnaire packs were requested, 63 were returned in various stages of completion. 56 De Paul fatigue questionnaires were returned: all but 12 met one of the CFS/ME criteria, but 12 or 22% of individuals did not fulfil the Fukuda nor the Clinical Canadian Criteria CFS/ME diagnostic criteria but 6 of them indicated that their fatigue was related to other causes and they barely had any symptoms. The five pilot participants completed 60% of the planned visits.ConclusionsSeverely affected CFS/ME individuals are keen to participate in research, however, their symptom burden is great and quality of life is poor. These factors must be considered when planning research and methods of engaging with such a cohort.
Sarcopenic obesity associated with high-sensitivity C-reactive protein in age and sex comparison: a two-center study in South Korea
Authors: Park Chul-Hyun , Do Jong Geol , Lee Yong-Taek , Yoon Kyung Jae 
Published: September 2018

ObjectivesTo evaluate the association between high-sensitivity C-reactive protein (hs-CRP) and sarcopenic obesity, and to determine age or sex differences underlying the relationship between hs-CRP and sarcopenic obesity.DesignObservational study.ParticipantsThe study included 237 838 participants whose body composition and hs-CRP were analysed at the two health promotion centres in South Korea. Participants were divided into four groups based on body composition: normal, obesity only, sarcopenia only and sarcopenic obesity.Primary measuresThe levels of hs-CRP and proportion of participants with high (≥1.0 mg/L) hs-CRP. Sarcopenic obesity was defined as subjects fulfilling the criteria for sarcopenia (below 2 SD of mean of Skeletal Muscle Mass Index for young adults) and obesity (waist circumference ≥90 cm for men and ≥85 cm for women).ResultsThe level of hs-CRP was highest in the sarcopenic obesity group. Following adjustment for various confounders including age, sex, comorbidities, metabolic, health-related behaviour and demographic factors, the adjusted ORs (95% CI) for subjects with high hs-CRP associated with obesity, sarcopenia and sarcopenic obesity compared with normal group (reference) were 1.17 (1.05 to 1.31), 2.23 (1.21 to 4.07) and 3.23 (2.71 to 3.83), respectively. In age subgroup analyses, multivariate logistic regression analysis revealed that the association of high hs-CRP with sarcopenic obesity was stronger in younger (<60 years) participants than in older (≥60 years) participants (p for interaction <0.001). In subgroup analyses for sex, the association of high hs-CRP with sarcopenic obesity was higher in female participants than in males (p for interaction <0.001).ConclusionsThis study demonstrated that high level of hs-CRP was independently associated with sarcopenic obesity in Korean population. We found for the first time that there was a strong association between increased hs-CRP and sarcopenic obesity in female and younger (<60 years) subjects.
Telehealth for patients with chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis protocol
Authors: Gaveikaite Violeta , Fischer Claudia , Schonenberg Helen , Pauws Steffen , Kitsiou Spyros , Chouvarda Ioanna , Maglaveras Nicos , Roca Josep 
Published: September 2018

IntroductionChronic obstructive pulmonary disease (COPD) is a highly prevalent chronic disease characterised by persistent respiratory symptoms. A focus of COPD interventional studies is directed towards prevention of exacerbations leading to hospital readmissions. Telehealth as a method of remote patient monitoring and care delivery may be implemented to reduce hospital readmissions and improve self-management of disease. Prior reviews have not systematically assessed the efficacies of various telehealth functionalities in patients with COPD at different stages of disease severity. We aim to evaluate which COPD telehealth interventions, classified by their functionalities, are most effective in improving patient with COPD management measured by both clinical and resource utilisation outcomes.Methods and analysisWe will conduct a systematic review which will include randomised controlled trials comparing the efficacy of telehealth interventions versus standard care in patients with COPD with confirmed disease severity based on forced expiratory volume(%) levels. An electronic search strategy will be used to identify trials published since 2000 in MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, CINHAL. Telehealth is described as remote monitoring and delivery of care where patient data/clinical information is routinely or continuously collected and/or processed, presented to the patient and transferred to a clinical care institution for feedback, triage and intervention by a clinical specialist. Two authors will independently screen articles for inclusion, assess risk of bias and extract data. We will merge studies into a meta-analysis if the interventions, technologies, participants and underlying clinical questions are homogeneous enough. We will use a random-effects model, as we expect some heterogeneity between interventions. In cases where a meta-analysis is not possible, we will synthesise findings narratively. We will assess the quality of the evidence for the main outcomes using GRADE.Ethics and DisseminationResearch ethics approval is not required. The findings will be disseminated through publication in a peer-reviewed journal.PROSPERO registration numberCRD42018083671.
Cross-sectional analysis of sleep-promoting and wake-promoting drug use on health, fatigue-related error, and near-crashes in police officers
Authors: Ogeil Rowan P , Barger Laura K , Lockley Steven W , O’Brien Conor S , Sullivan Jason P , Qadri Salim , Lubman Dan I , Czeisler Charles A , Rajaratnam Shantha M W 
Published: September 2018

ObjectivesTo examine sleep-promoting and wake-promoting drug use in police officers and associations between their use and health (excessive sleepiness, stress and burnout), performance (fatigue-related errors) and safety (near-crashes) outcomes, both alone and in combination with night-shift work.DesignCross-sectional survey.SettingPolice officers from North America completed the survey either online or via paper/pencil at a police station.Participants4957 police participated, 3693 online (91.9%, participation rate) and 1264 onsite (cooperation rate 63.1%).Main outcome measuresSleep-promoting and wake-promoting drug use, excessive sleepiness, near-crash motor vehicle crashes, dozing while driving, fatigue errors, stress and burnout.ResultsOver the past month, 20% of police officers reported using sleep-promoting drugs and drugs causing sleepiness, while wake-promoting agents were used by 28% of police (5% used wake-promoting drugs, 23% used high levels of caffeine and 4% smoked to stay awake). Use of sleep-promoting drugs was associated with increased near-crashes (OR=1.61; 95% CI 1.21 to 2.13), fatigue-related errors (OR=1.75; 95% CI 1.32 to 2.79), higher stress (OR=1.41; 95% CI 1.10 to 1.82), and higher burnout (OR=1.83; 95% CI 1.40 to 2.38). Wake-promoting drug use, high caffeine and smoking to stay awake were associated with increased odds of a fatigue-related error, stress and burnout (ORs ranging from 1.68 to 2.56). Caffeine consumption was common, and while smoking was not, of those participants who did smoke, one-in-three did so to remain awake. Night-shift work was associated with independent increases in excessive sleepiness, near-crashes and fatigue-related errors. Interactions between night-shift work and wake-promoting drug use were also found for excessive sleepiness.ConclusionsPolice who use sleep-promoting and wake-promoting drugs, especially when working night shifts, are most vulnerable to adverse health, performance and safety outcomes. Future research should examine temporal relationships between shift work, drug use and adverse outcomes, in order to develop optimal alertness management strategies.
Comparison of high flow nasal cannula oxygen and conventional oxygen therapy on ventilatory support duration during acute-on-chronic respiratory failure: study protocol of a multicentre, randomised, controlled trial. The ‘HIGH-FLOW ACRF’ study
Authors: Ricard Jean-Damien , Dib Fadia , Esposito-Farese Marina , Messika Jonathan , Girault Christophe 
Published: September 2018

IntroductionThis study protocol describes a trial designed to investigate whether high-flow heated and humidified nasal oxygen (HFHO) therapy in patients with hypercapnic acute respiratory failure (ARF) reduces the need of non-invasive ventilation (NIV).Methods and analysisThis is an open-label, superiority, international, parallel-group, multicentre randomised controlled two-arm trial, with an internal feasibility pilot phase. 242 patients with hypercapnic ARF requiring NIV admitted to an intensive care unit, an intermediate care or a respiratory care unit will be randomised in a 1:1 ratio to receive HFHO or standard oxygen in between NIV sessions. Randomisation will be centralised and stratified by centre and pH at admission (pH ≤7.25 or >7.25). The primary outcome will be the number of ventilator-free days (VFDs) and alive at day 28 postrandomisation. The secondary outcomes will encompass parameters related to the VFDs, comfort and tolerance variables, hospital length of stay and mortality. VFDs at 28 days postrandomisation will be compared between the two groups by Wilcoxon-Mann-Whitney two-sample rank-sum test in the intention-to-treat population. A sensitivity analysis will be conducted in the population of patients for whom the criteria of switching from NIV to spontaneous breathing, or conversely, are not strictly verified.Ethics and disseminationThe protocol has been approved by theComité de Protection des Personnes(CPP)Sud-Ouest & Outre-Mer IV(ref CPP17-049a/2017-A01830-53) and will be carried out in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. A trial steering committee will oversee the progress of the study. Findings will be disseminated through national and international scientific conferences, and publication in peer-reviewed journals.Trial registration numberNCT03406572.
Patient safety and the ageing physician: a qualitative study of key stakeholder attitudes and experiences
Authors: White Andrew A , Sage William M , Osinska Paulina H , Salgaonkar Monica J , Gallagher Thomas H 
Published: September 2018

BackgroundUnprecedented numbers of physicians are practicing past age 65. Unlike other safety-conscious industries, such as aviation, medicine lacks robust systems to ensure late-career physician (LCP) competence while promoting career longevity.ObjectiveTo describe the attitudes of key stakeholders about the oversight of LCPs and principles that might shape policy development.DesignThematic content analysis of interviews and focus groups.Participants40 representatives of stakeholder groups including state medical board leaders, institutional chief medical officers, senior physicians (>65 years old), patient advocates (patients or family members in advocacy roles), nurses and junior physicians. Participants represented a balanced sample from all US regions, surgical and non-surgical specialties, and both academic and non-academic institutions.ResultsStakeholders describe lax professional self-regulation of LCPs and believe this represents an important unsolved challenge. Patient safety and attention to physician well-being emerged as key organising principles for policy development. Stakeholders believe that healthcare institutions rather than state or certifying boards should lead implementation of policies related to LCPs, yet expressed concerns about resistance by physicians and the ability of institutions to address politically complex medical staff challenges. Respondents recommended a coaching and professional development framework, with environmental changes, to maximise safety and career longevity of physicians as they age.ConclusionsKey stakeholders express a desire for wider adoption of LCP standards, but foresee significant culture change and practical challenges ahead. Participants recommended that institutions lead this work, with support from regulatory stakeholders that endorse standards and create frameworks for policy adoption.
Seneca sandstone: a heritage stone from the USA
Authors: Grissom Carol A. , Aloiz Emily M. , Vicenzi Edward P. , Livingston Richard A. 
Published: September 2018

Abstract
Seneca sandstone is a fine-grained arkosic sandstone of dark-red coloration used primarily during the nineteenth century in Washington, DC. Several inactive Seneca sandstone quarries are located along the Potomac River 34 km NW of Washington near Poolesville, Maryland. Seneca sandstone is from part of the Poolesville Member of the Upper Triassic Manassas Formation, which is in turn a Member of the Newark Supergroup that crops out in eastern North America. Its first major public use is associated with George Washington, the first president of the Potomac Company founded in 1785 to improve the navigability of the Potomac River, with the goal of opening transportation to the west for shipping. The subsequent Chesapeake and Ohio Canal built parallel to the river made major use of Seneca sandstone in its construction and then facilitated the stone's transport to the capital for the construction industry. The most significant building for which the stone was used is the Smithsonian Institution Building or ‘Castle’ (1847–55), the first building of the Smithsonian Institution and still its administrative centre. Many churches, school buildings and homes in the city were built wholly or partially with the stone during the ‘brown decades’ of the latter half of the nineteenth century.
Genealogia do psíquico. Sobre A transcendência do ego–esboço de uma descrição fenomenológica, de Jean-Paul Sartre
Authors: Carrasco Alexandre de Oliveira Torres 
Published: September 2018

O texto que segue é a segunda parte de um estudo sobre A Transcendência do Ego, esboço de uma descrição fenomenológica, de J.-P. Sartre. O objeto é a concepção sartriana do ego, em referência às tradições cratesiana e fenomenológica. A primeira parte desse estudo foi publicada nos Cadernos Espinosanos, vol. XXVIII, em agosto de 2013.
No Differences in Levels of Circulating Progenitor Endothelial Cells or Circulating Endothelial Cells Among Patients Treated With Ticagrelor Compared With Clopidogrel During Non–ST‐Segment–Elevation Myocardial Infarction
Authors: Diego‐Nieto Alejandro , Vidriales Maria B. , Alonso‐Orcajo Norberto , Moreno‐Samos Jose C. , Martin‐Herrero Francisco , Carbonell Raul , Cid Belen , Cruz‐Gonzalez Ignacio , Martin‐Moreiras Javier C. , Cuellas Carlos , Pascual Cristina , Lopez‐Benito Maria , Sanchez Pedro L. , Fernandez‐Vazquez Felipe , de Prado Armando Perez 
Published: September 2018

Background

Ticagrelor use during acute coronary syndromes demonstrated a decrease in all‐cause mortality in the
PLATO
(Platelet Inhibition and Patient Outcomes) trial. This effect has been attributed to a non–platelet‐derived improvement in endothelial function. The aim of this study was to determine differences in the number of endothelial progenitor cells and/or circulating endothelial cells found in peripheral blood in patients treated with either ticagrelor or clopidogrel during non–ST‐segment–elevation myocardial infarction.

Methods and Results

In this multicenter, randomized study (
NCT
02244710), patients were considered for inclusion after non–ST‐segment–elevation myocardial infarction whenever they were P2Y
12
‐inhibitor naïve. Ticagrelor and clopidogrel were allocated at a 1:1 ratio. Blood samples for determining endothelial progenitor cells and circulating endothelial cells were extracted before the antiplatelet loading dose, 48 hours after presentation of index symptoms, and 1 month after the event. A multichannel cytometer was used for optimal cell characterization. A total of 96 patients fulfilled the inclusion criteria. Circulating endothelial cell levels corrected by white blood cells were as follows at baseline, 48 hours, and 1 month: 44 (28–64), 50 (33–63), and 38 (23–62) cells/mL, respectively, for clopidogrel and 38 (29–60), 45 (32–85), and 35 (24–71) cells/mL, respectively, for ticagrelor (
P
=0.6). Endothelial progenitor cell levels were 29 (15–47), 27 (15–33), and 18 (10–25) cells/mL, respectively, for clopidogrel and 20 (11–33), 22 (12–32), and 18 (11–29) cells/mL, respectively, for ticagrelor (
P
=0.9). No differences in intraindividual changes were found.

Conclusions
Patients treated with ticagrelor during non–ST‐segment–elevation myocardial infarction, in comparison to clopidogrel, showed similar levels of endothelial progenitor cells and circulating endothelial cells. These data suggest that the endothelial protective effect mediated by ticagrelor is not related to bone marrow physiology modulation.

Clinical Trial Registration

URL:
https://www.clinicaltrials.gov
. Unique identifier:
NCT
02244710.
The Impact of Climate Change on the Water Balance of Oil Sands Reclamation Covers and Natural Soil Profiles
Authors: Alam Md. Shahabul , Barbour S. Lee , Elshorbagy Amin , Huang Mingbin 
Published: September 2018

Abstract
The design of reclamation soil covers at oil sands mines in northern Alberta, Canada, has been conventionally based on the calibration of soil–vegetation–atmosphere transfer (SVAT) models against field monitoring observations collected over several years, followed by simulations of long-term performance using historical climate data. This paper evaluates the long-term water balances for reclamation covers on two oil sands landforms and three natural coarse-textured forest soil profiles using both historical climate data and future climate projections. Twenty-first century daily precipitation and temperature data from CanESM2 were downscaled based on three representative concentration pathways (RCPs) employing a stochastic weather generator [Long Ashton Research Station Weather Generator (LARS-WG)]. Relative humidity, wind speed, and net radiation were downscaled using the delta change method. Downscaled precipitation and estimated potential evapotranspiration were used as inputs to simulate soil water dynamics using physically based models. Probability distributions of growing season (April–October) actual evapotranspiration (AET) and net percolation (NP) for the baseline and future periods show that AET and NP at all sites are expected to increase throughout the twenty-first century regardless of RCP, time period, and soil profile. Greater increases in AET and NP are projected toward the end of the twenty-first century. The increases in future NP at the two reclamation covers are larger (as a percentage increase) than at most of the natural sites. Increases in NP will result in greater water yield to surface water and may accelerate the rate at which chemical constituents contained within mine waste are released to downstream receptors, suggesting these potential changes need to be considered in mine closure designs.
Impacts of Atmospheric Rivers on Precipitation in Southern South America
Authors: Viale Maximiliano , Valenzuela Raúl , Garreaud René D. , Ralph F. Martin 
Published: September 2018

AbstractThis study quantifies the impact of atmospheric rivers (ARs) on precipitation in southern South America. An AR detection algorithm was developed based on integrated water vapor transport (IVT) from 6-hourly CFSR reanalysis data over a 16-yr period (2001–16). AR landfalls were linked to precipitation using a comprehensive observing network that spanned large variations in terrain along and across the Andes from 27° to 55°S, including some sites with hourly data. Along the Pacific (west) coast, AR landfalls are most frequent between 38° and 50°S, averaging 35–40 days yr−1. This decreases rapidly to the south and north of this maximum, as well as to the east of the Andes. Landfalling ARs are more frequent in winter/spring (summer/fall) to the north (south) of ~43°S. ARs contribute 45%–60% of the annual precipitation in subtropical Chile (37°–32°S) and 40%–55% along the midlatitude west coast (37°–47°S). These values significantly exceed those in western North America, likely due to the Andes being taller. In subtropical and midlatitude regions, roughly half of all events with top-quartile precipitation rates occur under AR conditions. Median daily and hourly precipitation in ARs is 2–3 times that of other storms. The results of this study extend knowledge of the key roles of ARs on precipitation, weather, and climate in the South American region. They enable comparisons with other areas globally, provide context for specific events, and support local nowcasting and forecasting.
Tornadogenesis in the 12 May 2010 Supercell Thunderstorm Intercepted by VORTEX2 near Clinton, Oklahoma
Authors: Markowski Paul M. , Hatlee Timothy P. , Richardson Yvette P. 
Published: September 2018

AbstractThe 12 May 2010 supercell thunderstorm intercepted by the Second Verification of the Origins of Rotation in Tornadoes Experiment (VORTEX2) is analyzed during a time period of strong low-level rotation in which dual-Doppler radar observations were collected. Two different cyclonic vortices are documented. The first vortex was “marginally tornadic” before abruptly weakening, following the development of a descending reflectivity core (DRC) similar to those that have been documented in past studies of supercells. The second vortex rapidly developed immediately north of the DRC shortly after the DRC reached low altitudes, and was associated with a tornado that produced damage near Clinton, Oklahoma. The paper explores the possible roles of the first vortex in triggering the DRC, the DRC in the subsequent initiation of a new updraft pulse on its flank, and the updraft pulse on the development of the second, stronger vortex. The Clinton storm case is, unfortunately, a nice example of the challenges in predicting tornadogenesis within supercell storms even in environments understood to be favorable for tornadoes.