bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacological interventions for remifentanil-induced hyperalgesia: A systematic review and network meta-analysis of preclinical trials
Authors: Koponen Mia E. , Naray Emily , Hales Tim G. , Forget Patrice 
Published: December 2024

Background
To improve perioperative pain management, several interventions have been suggested for the prevention of increased pain sensitivity caused by opioids (called opioid-induced hyperalgesia). It is currently unclear which intervention is the most effective or appropriate in preventing opioid-induced hyperalgesia. Remifentanil is the most investigated opioid causing opioid-induced hyperalgesia. Thus, to guide future research, we conducted a systematic review and a network meta-analysis of preclinical trials investigating pharmacological interventions for remifentanil-induced hyperalgesia.

Methods
To identify relevant articles, electronic database searches were conducted in Embase, PubMed, Web of Science, and Google Scholar. Study characteristics were extracted, and the risk of bias was evaluated. Studies were included in the network meta-analysis if they shared similar characteristics with at least one other study. The interventions were ranked based on P-scores.

Results
Overall, the 62 eligible trials tested 86 individual interventions and 6 combination interventions. Thirty-five studies eligible in the network meta-analysis formed five groups which were further divided into subgroups based on the quantitative sensory tests used. The best-ranked interventions within the subgroups were Anxa12-26, MRS2179, salicylaldehyde isonicotinoyl hydrazone (SIH), ANA-12, TDZD-8, ketamine, dexmedetomidine, JWH015, and the combination of KN93 and ketamine.

Discussion
The current literature is too heterogeneous to produce a clear answer on which intervention is the most effective in preventing remifentanil-induced hyperalgesia. Future research in this field should prioritise finding the most effective intervention over testing the efficacy of new options. The results of our work can be used in planning which comparisons should be included in new trials.
Effect of perioperative dexmedetomidine on sleep quality in adult patients after noncardiac surgery: A systematic review and meta-analysis of randomized trials
Authors: Wang Lin , Liang Xin-Quan , Sun Yan-Xia , Hua Zhen , Wang Dong-Xin 
Published: December 2024

Background
Dexmedetomidine may improve sleep quality after surgery, but conflicting results also exist. Herein, we explored the effects of perioperative dexmedetomidine on postoperative sleep quality in adult patients.

Methods
In this systematic review and meta-analysis, randomized controlled trials investigating the effects of perioperative dexmedetomidine on sleep quality after noncardiac surgery were retrieved from Cochrane Library, PubMed, and EMBASE from inception to January 12, 2023, and updated on March 15, 2024. The Cochrane Collaboration’s tool was applied to assess risk of bias. A random-effects model was used for meta-analysis. The primary outcome was the subjective sleep quality score on the first night after surgery.

Results
A total of 29 trials containing 5610 participants were included. The subjective sleep score on the first postoperative night was lower (better) with dexmedetomidine than with placebo (SMD [standardized mean difference] = -0.8, 95% CI -1.1 to -0.6, p<0.00001; I2 = 93%; 22 trials; n = 4611). Sensitivity analysis showed that overall conclusion was not changed (SMD = -0.8, 95% CI -1.1 to -0.5, p<0.00001; I2 = 93%; 14 trials; n = 3846). Results of polysomnographic monitoring showed improved sleep structure with dexmedetomidine on the first night after surgery, as manifested by increased sleep efficiency index and stage N2 sleep and decreased arousal index and stage N1 sleep.

Conclusions
This systematic review suggests that, among patients who underwent noncardiac surgery, perioperative dexmedetomidine administration may improve early postoperative sleep quality pattern. However, the resulting evidence were of low or very low qualities and further studies are required to confirm our results.

PROSPERO registration number
CRD42023390972.
Comparison of journal and top publisher self-citation rates in COVID-19 research
Authors: Quincho-Lopez Alvaro 
Published: December 2024

Introduction
Journal self-citation contributes to the overall citation count of a journal and to some metrics like the impact factor. However, little is known about the extent of journal self-citations in COVID-19 research. This study aimed to determine the journal self-citations in COVID-19 research and to compare them according to the type of publication and publisher.

Methods
Data in COVID-19 research extracted from the Web of Science Core Collection 2020–2023 was collected and further analyzed with InCites. The journals with the highest self-citation rates and self-citation per publication were identified. Statistical comparisons were made according to the type of publication and publishers, as well as with other major infectious diseases.

Results
The median self-citation rate was 4.0% (IQR 0–11.7%), and the median journal self-citation rate was 5.9% (IQR 0–12.5%). 1,859 journals (13% of total coverage) had self-citation rates at or above 20%, meaning that more than one in five references are journal self-citations. There was a positive and statistically significant correlation of self-citations with the other indicators, including number of publications, citations, and self-citations per publication (p<0.001). Editorial materials contributed more to journal SC with a median self-citation rate of 5%, which was statistically higher than other documents such as articles, letters or reviews (p<0.001). Among the top twelve publishers, the Multidisciplinary Digital Publishing Institute had a median self-citation rate of 8.33% and was statistically higher than the rest (p<0.001). Self-citation rates for COVID-19 were lower than tuberculosis and HIV/AIDS, but self-citations per publication of these diseases were statistically lower than those for COVID-19 (p<0.001).

Conclusion
Some journals from the Web of Science Core Collection displayed exorbitant journal self-citation patterns during the period 2020–2023. Approximately, one in every five paper references in COVID-19 is a journal self-citation. Types of publication such as editorials engage in this practice more frequently than others, suggesting that in COVID-19 research, self-citing non-citable items could potentially contribute to inflate journal impact factors during the pandemic.
Contemporary Disney Animation: Genre, Gender and Hollywood, Eve Benhamou (2022)
Authors: O’Flanagan Laura 
Published: December 2024

Review of: Contemporary Disney Animation: Genre, Gender and Hollywood, Eve Benhamou (2022)
Edinburgh: Edinburgh University Press, 264 pp.,
ISBN 978-1-47447-612-6, h/bk, £85.00
ISBN 978-1-47447-613-3, p/bk, £24.99
ISBN 978-1-47447-614-0, e-book, £24.99
PENDAMPINGAN PEMBUTAN MEDIA PROMOSI DESA WISATA MUNDING
Authors: Ratna Maharani Patria , Saputri Lenggahing 
Published: December 2024

ABSTRAKKegiatan pengabdian masyarakat ini bertujuan untuk membantu masyarakat Desa Wisata Munding, Kecamatan Bergas, Kabupaten Semarang, dalam membuat media promosi. Metode yang digunakan meliputi pelatihan, pendampingan, dan evaluasi. Pelatihan diberikan kepada masyarakat mengenai teknik fotografi dan videografi, serta strategi pemasaran digital. Pendampingan dilakukan selama proses pembuatan website dan booklet. Evaluasi dilakukan untuk mengukur keberhasilan program dan memberikan umpan balik untuk perbaikan. Hasil dari kegiatan pengabdian masyarakat ini adalah website dan booklet yang informatif dan menarik, serta peningkatan kemampuan masyarakat dalam memanfaatkan teknologi informasi untuk mempromosikan desa wisata.Kata kunci: desa wisata, media promosi, pemberdayaan masyarakat, pariwisata berkelanjutan, teknologi informasiABSTRACTThis community service activity aims to assist the community of Munding Tourism Village, Bergas Sub-district, Semarang Regency, in creating promotional media. The methods employed include training, mentoring, and evaluation. Training was provided to the community on photography and videography techniques, as well as digital marketing strategies. Mentoring was conducted throughout the process of creating a website and booklet. Evaluation was carried out to measure the program's success and provide feedback for improvement. The results of this community service activity are an informative and attractive website and booklet, as well as an increase in the community's ability to utilize information technology for promoting the tourism village.Keywords: tourism village, promotional media, community empowerment, sustainable tourism, information technology
Circ_0089761 accelerates colorectal cancer metastasis and immune escape via miR‐27b‐3p/PD‐L1 axis
Authors: Gao Qizhong , Cheng Xiaowei , Gao Xiang 
Published: December 2024

AbstractCircular RNAs have been implicated as critical regulators in the initiation and progression of colorectal cancer (CRC). This study was intended to elucidate the functional significance of the circ_0089761/miR‐27b‐3p/programmed cell death ligand 1 (PD‐L1) axis in CRC. Our findings indicated that circ_0089761 expression was significantly elevated in CRC tissues and cell lines. Furthermore, the high expression of circ_0089761 was correlated with TNM stage and tumor size. Silencing circ_0089761 inhibited CRC cell proliferation, migration, and invasion, and increased apoptosis. Mechanistically, circ_0089761 facilitated its biological function by binding to miR‐27b‐3p to upregulate PD‐L1 expression in CRC. Coculture experiments confirmed that low expression of circ_0089761 impeded CD8 + T cell apoptosis and depletion, activated CD8 + T cell function, and increased secretion of the immune effector cytokines IFN‐γ, TNF‐α, perforin, and granzyme‐B. MiR‐27b‐3p inhibition or PD‐L1 overexpression partially impeded CD8 + T cell function. The circ_0089761/miR‐27b‐3p/PD‐L1 axis is postulated to exert pivotal functions in the mechanistic progression of CRC. Furthermore, it holds promising prospects as a feasible biomarker and therapeutic target for CRC.
Introduction: Archival Crossings – A Mobile Archive Research Cluster
Authors: Hallock Thomas , Hartwig Marcel 
Published: December 2024

Abstract
Initiated during the COVID-19 pandemic, the Mobile Archive project explores how archival research has adapted to the digital age. This is an ongoing, flexible inquiry into the status of the archive in Colonial and Early American Studies for our present day. In 2021, scholars from the US, Mexico, and Germany started the research project to examine how the shift from physical to digital archives has influenced knowledge organization, access, and historical narratives. Key discussions include the mobility of knowledge, the role of colonial legacies in archival practice, and the complexities of digitization. In this Anglia research cluster, we want to foster interdisciplinary dialogue among scholars, archivists, and university teachers. Here, we rethink archives as dynamic spaces that challenge traditional boundaries and promote more inclusive, decolonized scholarship. This introduction lays out the themes explored in this research cluster.
Archival Crossings in Research into Colonial Afro-Andean Histories in Peru
Authors: Garofalo Leo J. 
Published: December 2024

Abstract
Research into colonial Afro-Andean histories in Peru involves multiple crossings. Ethnohistory encourages researchers to cross disciplinary boundaries to try and reconstruct a more complete view of groups without a privileged place in the historical record. Beyond the methodological crossings that this approach and this subject require, there loom the often uncommented on archival crossings. These are formative in our orientations as academic researchers and transformative of our interpretive lens and the narratives we write and deliver orally. As important as these crossings are, we rarely comment on them in our scholarly publications, much less delve deeply into what they mean and how they shape us and condition how we view the past and its present-day relevance to us and others. The following pages will address my archival research into Afro-Andean experiences in colonial Peru. It takes place in what I call ‘living archives’. These are Church and state repositories that are still growing – sometimes daily – as parish records – such as marriage records – accumulate and are moved from local churches to the Archbishopric’s archives and notarial records are transferred to regional or national archives upon the death of the public notary or the closing of a notary’s office or practice. I wonder who will be the historians a hundred years from now who look at these records of our lives and deaths today. What will they make of our hopes and sorrows? Will they be any more adept than we are to make ‘informed’ guesses? And every day, I watch and sympathize as archivists struggle to make new spaces and install new shelving to house their unique and growing collection. Without their everyday efforts, those future approximations of our everyday lives will be infinitely more difficult and tentative. Every day I am reminded that these are ‘living archives’ in another very important way: members of the general public arrive every day to seek marriage, birth, and death records, or the titles to lands and other properties or inheritances. Although, it makes me uncomfortable that people must divulge all of this in front of me and other strangers busily beavering away to advance our careers and the ‘creation of knowledge’, as we like to say to ourselves, funders, and our administrative handlers, it humbles me as an interpreter of the past, makes me even more sympathetic to those whose traces of lives and hopes flight across the pages before me, and engenders a deep sense of gratitude and admiration for the archivists in these ‘living archives’ who make my work possible while also striving to meet the needs of the general public and future generations of Peruvians and historians.
A Postcolonial Wasteland in the Caribbean Post-Holocene: Katia D. Ulysse’s Mouths Don’t Speak as a Portrait of Haitian/American Implication in Haiti’s Tropical Apocalypse
Authors: Roldán-Sevillano Laura 
Published: December 2024

Abstract
This article examines Katia D. Ulysse’s Mouths Don’t Speak (2018) as a realist narrative which presents Ulysse’s motherland, Haiti, as a postcolonial wasteland of repeated natural disasters, political turmoil and extreme poverty in many cases engendered by the neocolonial interventionism of the US and other countries as well as the contribution of the Haitian elite and the Americanised Haitian diasporas like Ulysse’s protagonists. Hence, drawing on ecocritical theories around waste (Simal-González 2019, 2022; Armiero 2021), the post-Holocene era (Crutzen and Schwägerl 2011; Moore 2015, 2016b) and the concept of the “implicated subject” (Rothberg 2019), I analyse the novel’s portrayal of the aforementioned actors’ implication in contemporary Haiti’s eco-social apocalypse as a way to offer a pluralistic blaming for the gradual ‘wastification’ of this Caribbean country since colonial times.1
A control perspective on hybrid membrane/distillation propane/propylene separation process
Authors: Sattari Zohre , Ahmadian Behrooz Hesam 
Published: December 2024

Abstract
This study explores the design, dynamic behavior, and controllability of a hybrid membrane-distillation process for propane/propylene separation, offering a novel comparison with traditional single distillation columns. Our key innovation lies in integrating hollow fiber membrane technology with distillation to significantly improve process efficiency, reducing energy consumption and operational costs. Using rigorous economic and dynamic simulations, the hybrid process demonstrates superior performance, achieving a 12.6 % reduction in total annual cost (TAC) compared to the conventional distillation system. Advanced control methodologies, including Singular Value Decomposition (SVD) and condition number analysis, are applied to assess and optimize the controllability of the hybrid structure under disturbances such as fluctuations in feed composition and flow rates. The results highlight the hybrid process’s ability to maintain high product purity and faster dynamic response, offering a robust solution for large-scale propane/propylene separation in the petrochemical industry. This work provides crucial insights into improving both operational efficiency and control robustness in industrial separation processes.
Dual-loop PID control strategy for ramp tracking and ramp disturbance handling for unstable CSTRs
Authors: Das Dipjyoti , Chakraborty Sudipta , Kumar Deepak , Raja G. Lloyds 
Published: December 2024

Abstract
Control strategies designed for step signals fail when applied for ramp tracking and ramp disturbance rejection. Hence, this work presents a novel dual-loop control technique for ramp tracking and ramp disturbance rejection in unstable systems. To begin with, first the unstable process is stabilized using a proportional-derivative (PD) compensator (in the internal loop). This PD compensator was created utilising the direct synthesis approach. Using the loop shaping approach, a proportional-integral-derivative controller (in the outer-loop) is then developed to integrate stabilised plant dynamics. Simulations are done using standard unstable CSTR (Continuous Stirred Tank Reactor) plant models by applying step/ramp reference signals and disturbances. The proposed control strategy shows a satisfactory servo and regulatory response than the existing designs while dealing with step and ramp types of signals. Lastly, a performance summary is also presented on different errors.
Effects of home vacuum packaging method at different storage conditions on total antioxidant and phenolic compound levels in berry fruits
Authors: Nisari Mustafa , Basmisirli Eda , Aykemat Yusuf , Aytekin-Sahin Gizem , Inanc Neriman , Dishan Adalet 
Published: December 2024

Abstract
This study aimed to investigate the effects of home vacuum packaging on the total antioxidant capacity (TAC) and total phenolic content (TPC) levels of seven types of berries (raspberry, hawthorn, goldenberry, blackberry, strawberry, redcurrant, and blueberry) under different storage conditions. The berries were either vacuum+ or vacuum− and stored in a household refrigerator at +4 °C or frozen at −18 °C. Samples stored at +4 °C were analyzed on days 0, 7, and 30, while frozen samples were analyzed on days 0, 30, and 90. The results showed that TAC levels of fruit samples decreased by 18.88 % after 30 days at +4 °C in the vacuum− samples, while the vacuum+ samples showed only a 9.64 % reduction. Similarly, after 90 days of freezing, TAC levels decreased by 19.35 % in vacuum− samples, compared to an 11.56 % reduction in vacuum+ samples. Moreover, TPC levels of fruit samples decreased by 81.81 % after 30 days at +4 °C in the vacuum− samples, while the vacuum+ samples showed a 72.99 % reduction. After 90 days of freezing, TPC levels decreased by 75.99 % in vacuum− samples, while the vacuum+ samples showed only a 48.30 % reduction. Although TAC and TPC levels decreased over time at both +4 °C and −18 °C, the vacuum+ samples generally retained higher levels of TAC and TPC compared to the vacuum− samples, suggesting that vacuum packaging can slow down enzymatic and oxidative reactions. These findings indicate that home vacuum packaging could be a useful method for preserving the nutritional quality of berries and potentially reducing food waste.
Creatine supplementation strategies aimed at acutely increasing and maintaining skeletal muscle total creatine content in healthy, young volunteers
Authors: Pittas George , Miller Jan , Laithwaite David , Greenhaff Paul 
Published: December 2024

Abstract

Objectives
Insight regarding dietary creatine (Cr) supplementation strategies to acutely increase and maintain muscle total creatine (TCr) content is missing.

Methods
Healthy, young, men ingested 4 × 5 g Cr/day (d) for 5d, followed by 5 g/d for 28 d (Cr group, n=8). To achieve insulin mediated muscle Cr transport, another group (n=16) ingested 4 × 5 g Cr plus 95 g dextrose/d for 5d (CrCHO), and thereafter two sub-groups ingested 5 g of Cr (CrCHO1, n=8) or 5 g Cr plus 95 g dextrose/d for 28 d (CrCHO2, n=8). A fourth group ingested 4 × 5g of Cr plus 14 g protein, 7 g phenylalanine, 7 g leucine and 57 g dextrose/d for 5 d, and once/d thereafter for 28 d (CrPAC, n=8). Muscle biopsies were obtained at 0, and after 5 and 33 d.

Results
After 5 d, muscle TCr increased in Cr (p<0.001), CrCHO (p<0.001), and CrPAC (p<0.05) groups, and was numerically greatest in CrCHO; achieving a content reported to be an average maximum (150 mmol/kg). After 33 d, TCr also increased to ~150 mmol/kg in the Cr group (p<0.05), remained unchanged from 5 d in CrCHO2, and tended to decline in CrCHO1. Muscle TCr remained unchanged from 5 d in CrPAC after 33 d, being less than the Cr group (p<0.05). Muscle Cr transporter mRNA expression changed modestly, but the increase in muscle TCr after 5 d was inversely associated with fold-change in mRNA expression (r=0.502, p<0.05).

Conclusions
A maximum increase in muscle TCr is achieved after 5 d Cr ingestion alongside 95 g dextrose, and continued consumption of Cr with dextrose will maintain this maximum. Ingestion of Cr alone will achieve a high muscle TCr content too, but takes longer.
Perspectivas prácticas del Cuadro de Mando Integral en el turismo sostenible: una revisión documental
Authors: Villasmil Molero Milagros , Mendoza Vega Lilia , Fontalvo Cerpa Winston 
Published: December 2024

Objetivo: Analizar las perspectivas prácticas del Cuadro de Mando Integrado aplicado al turismo sostenible a través de una revisión sistemática de literatura. Metodología o método: Se aplicó un enfoque cualitativo de diseño documental y tipo descriptivo, revisando 70 investigaciones teniendo en cuenta la declaración Prisma para evitar sesgos en el bosquejo. Se seleccionaron los textos a través de flujograma. Resultados: El análisis de los artículos reveló que el Cuadro de Mando Integral fue una herramienta valiosa en la gestión del turismo sostenible. Se destacó su utilidad en áreas como la promoción turística, la gestión de la calidad del servicio y la adaptación al cambio climático. Además, se evidenció su relevancia en la gestión de crisis y recursos humanos en la industria turística. En distintos contextos geográficos y sectoriales, el Cuadro de Mando Integral se utilizó para mejorar la competitividad y sostenibilidad de las empresas turísticas, desde destinos urbanos hasta comunidades locales. Conclusiones: Aunque se reconocieron las limitaciones de la revisión, este estudio resaltó el potencial del Cuadro de Mando Integral para futuras investigaciones, especialmente en áreas emergentes y la integración de nuevas tecnologías para mejorar la gestión estratégica y la sostenibilidad del turismo.