bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning methods to reverse engineer dynamic gene regulatory networks governing cell state transitions
Authors: Tsakanikas P. , Manatakis D. , Manolakos E. S. 
Published: February 2018

ABSTRACTDeciphering the dynamic gene regulatory mechanisms driving cells to make fate decisions remains elusive. We present a novel unsupervised machine learning methodology that can be used to analyze a dataset of heterogeneous single-cell gene expressions profiles, determine the most probable number of states (major cellular phenotypes) represented and extract the corresponding cell sub-populations. Most importantly, for any transition of interest from a source to a destination state, our methodology can zoom in, identify the cells most specific for studying the dynamics of this transition, order them along a trajectory of biological progression in posterior probabilities space, determine the "key-player" genes governing the transition dynamics, partition the trajectory into consecutive phases (transition "micro-states"), and finally reconstruct causal gene regulatory networks for each phase. Application of the end-to-end methodology provides new insights on key-player genes and their dynamic interactions during the important HSC-to-LMPP cell state transition involved in hematopoiesis. Moreover, it allows us to reconstruct a probabilistic representation of the “epigenetic landscape” of transitions and identify correctly the major ones in the hematopoiesis hierarchy of states.
Functional determinants of enhanced and depressed inter-areal information flow in NREM sleep between neuronal ensembles in rat cortex and hippocampus
Authors: Olcese Umberto , Bos Jeroen J. , Vinck Martin , Pennartz Cyriel M.A. 
Published: February 2018

AbstractCompared to wakefulness, neuronal activity during non-REM sleep is characterized by a decreased ability to integrate information, but also by the re-emergence of task-related information patterns. To investigate the mechanisms underlying these seemingly opposing phenomena, we measured directed information flow by computing transfer entropy between neuronal spiking activity in three cortical regions and the hippocampus of rats across brain states. State-dependent information flow resulted to be jointly determined by the anatomical distance between neurons and by their functional specialization. We distinguished two regimes, operating at short and long time scales, respectively. From wakefulness to non-REM sleep, transfer entropy at short time scales increased for inter-areal connections between neurons showing behavioral task correlates. Conversely, transfer entropy at long time scales became stronger between non-task modulated neurons and weaker between task- modulated neurons. These results may explain how, during non-REM sleep, a global inter-areal disconnection is compatible with highly specific task-related information transfer.Author SummaryThe brain remains active during deep sleep, yet we still do not know which rules govern information processing between neurons across wakefulness and sleep. Here we provide a first study of how information flow at the level of spiking activity varies as a function of brain state, temporal scale, brain area and behavioral task correlates of single neurons. We found that inter-areal communication at millisecond time scales is enhanced during sleep compared to wakefulness between neurons that code for task information. Conversely, non-modulated neurons showed more prominent communication at longer time scales. These results indicate that multiple, functionally determined communicative architectures coexist in the brain, and provide a novel framework to understand information processing and its consequences during sleep.
The Atypical Rho GTPase CHW-1 Works With SAX-3/Robo to Mediate Axon Guidance inCaenorhabditis elegans
Authors: Alan Jamie K. , Robinson Sara , Magsig Katie , Demarco Rafael S. , Lundquist Erik A. 
Published: February 2018

AbstractDuring development, neuronal cells extend an axon towards their target destination in response to a cue to form a properly functioning nervous system. Rho proteins, Ras-related small GTPases that regulate cytoskeletal organization and dynamics, cell adhesion, and motility, are known to regulate axon guidance. Despite extensive knowledge about canonical Rho proteins (RhoA/Rac1/Cdc42), little is known about theCaenorhabditis elegans(C. elegans) atypical Cdc42-like family members CHW-1 and CRP-1 in regards to axon pathfinding and neuronal migration.chw-1(Chp/Wrch) encodes a protein that resembles human Chp (Wrch-2/RhoV) and Wrch-1 (RhoU), andcrp-1encodes for a protein that resembles TC10 and TCL. Here, we show thatchw-1works redundantly withcrp-1andcdc-42in axon guidance. Furthermore, proper levels ofchw-1expression and activity are required for proper axon guidance. When examining CHW-1 GTPase mutants, we found that the native CHW-1 protein is likely partially activated, and mutations at a conserved residue (position 12 using Ras numbering, position 18 in CHW-1) alter axon guidance and neural migration. Additionally, we showed thatchw-1genetically interacts with the guidance receptorsax-3in PDE neurons. Finally, in VD/DD motor neurons,chw-1works downstream ofsax-3to control axon guidance. In summary, this is the first study implicating the atypical Rho GTPaseschw-1andcrp-1in axon guidance. Furthermore, this is the first evidence of genetic interaction betweenchw-1and the guidance receptorsax-3. These data suggest thatchw-1is likely acting downstream and/or in parallel tosax-3in axon guidance.
Electron crystallography with the EIGER detector
Authors: Tinti Gemma , Fröjdh Erik , van Genderen Eric , Gruene Tim , Schmitt Bernd , de Winter D. A. Matthijs , Weckhuysen Bert M. , Abrahams Jan Pieter 
Published: February 2018

Electron crystallography is a discipline that currently attracts much attention as method for inorganic, organic and macromolecular structure solution. EIGER, a direct-detection hybrid pixel detector developed at the Paul Scherrer Institut, Switzerland, has been tested for electron diffraction in a transmission electron microscope. EIGER features a pixel pitch of 75 × 75 µm2, frame rates up to 23 kHz and a dead time between frames as low as 3 µs. Cluster size and modulation transfer functions of the detector at 100, 200 and 300 keV electron energies are reported and the data quality is demonstrated by structure determination of a SAPO-34 zeotype from electron diffraction data.
Principled negotiation: an evidence-based perspective
Authors: Hak Frederik Reinder , Sanders Karin 
Published: February 2018

PurposeThe purpose of this paper is to argue that the adaptation of the principled negotiation approach within organizations demonstrates similarities with the adaptation of evidence-based management and is the result of cognitive biases and cultural values instead of specific and conscious choices within the adopted negotiation style.Design/methodology/approachThe adaptation of principled negotiation and evidence-based management are considered as a lack of willingness to be innovative at the organizational level, and when these ideas are introduced will meet resistance.FindingsThe analysis of the principled negotiation approach as an approach which – similar to evidence-based management – is vulnerable to cognitive biases and cultural values offers a solution on how to effectively adapt this approach within organizations.Research limitations/implicationsImplications for research include a research design to test the assumptions of this paper to consider principled negotiations and evidence-based management approaches as innovative approaches.Practical implicationsOrganizations and decision makers within organizations can benefit from the analysis in this paper.Social implicationsCompanies and parties in a negotiation phase can benefit from the analysis by paying attention to the cognitive biases and cultural values of the other parties rather than paying attention to the first offer and the choices made in the negotiation.Originality/valueThis is the first paper to analyze principled negotiations from an evidence-based management perspective.
Voicing concerns for greater engagement
Authors: Gupta Manish , Ravindranath Sindhu , Kumar Y.L.N. 
Published: February 2018

PurposeScholars argue that supervisor’s job insecurity may affect subordinates’ work engagement. Moreover, this relationship may be mediated by subordinates’ pro-social voice and the relationship between the supervisor’s job insecurity and subordinates’ pro-social voice may be moderated by organizational culture. Therefore, the purpose of this paper is twofold. First, to examine the mediating role of the subordinate’s pro-social voice between supervisor’s job insecurity and subordinates’ work engagement. Second, to test the moderating role of organizational culture between supervisor’s job insecurity and the subordinates’ pro-social voice.Design/methodology/approachData were gathered from employees of a large hospital in India using face-to-face data cross-sectional survey method. To test the proposed hypotheses, ordinary least squares regression analysis was performed on the data obtained.FindingsThe results indicated support for the proposed model in two ways. First, the subordinate’s pro-social voice mediated the relationship between supervisor’s job insecurity and the subordinate’s work engagement. Second, organizational culture acted as a moderator between supervisor’s job insecurity and the subordinate’s pro-social voice.Research limitations/implicationsThe results augment social exchange theory by identifying the crucial role that voicing concerns plays in reducing the negative impact of supervisor’s job insecurity on the subordinates’ work engagement.Practical implicationsThe study findings encourage managers to create an organizational culture that allows the subordinates to challenge their supervisor’s decisions.Originality/valueTo the best of the researchers’ knowledge, this is the first study to test job insecurity of the supervisors instead of the same respondents as a predictor of pro-social voice.
Obstacles and methods of financing for the development of local entrepreneurship in Iran
Authors: Sadeghloo Tahereh , Sojasi Qeidari Hamdollah , Salehi Mahdi , Faal Jalali Amin 
Published: February 2018

Purpose
The purpose of the current study is to investigate the public and private financing obstacles to medium- and small-scale entrepreneurs in rural areas in Iran.

Design/methodology/approach
Descriptive analytic research method is used for collecting field data among 5,770 owners of entrepreneurial businesses located in rural areas of Mashhad in 2015.

Findings
The results showed that there are numerous public and private obstacles in rural entrepreneurship financing in Iran, which are the main factors for short-term loan repayment in public sector, and in the private sector, they result in entrepreneurs’ lack of access to the source of financing. Moreover, there are a variety of financing methods for entrepreneurship in rural areas, among which personal resources and borrowings are the most important ones. Thus, lack of serious and persistent governmental support from local entrepreneurs causes many entrepreneurial failures at the early stages of entrepreneurial activity in villages of Iran.

Originality/value
So far, few studies have been conducted on the subject of the study; hence, the results of the current study may be helpful to the developing nations.
Effects of ethnic changes on house prices: Sydney cases
Authors: Ge Xin Janet 
Published: February 2018

Purpose
This paper aims to investigate the factors that contribute to the changes of house prices including ethnic factors. Australia is a multicultural country with diversified ethnicities. The median price of established houses (unstratified) in Sydney has reached a new record high of $910,000 in December 2015, increasing around 58.2 per cent from March 2011 [Australian Bureau of Statistics (ABS), 2015a]. However, the prices of some suburbs have increased more than prices of others.

Design/methodology/approach
Six suburbs that represent ethnic majority originally including White, India and China will be selected as pilot studies. Hedonic regression analysis will be applied for the analysis based on 2001, 2006 and 2011 census data.

Findings
It is found that the main drivers of house prices are the dwelling physical characteristics and accessibility to convenient transportation. The level of household income also plays an important role. However, the impact of changes of ethnic on changes of prices is not significant.

Research limitations/implications
The study adds to the growing literature on the ethnicity changes on dwelling prices and is important for understanding whether some of the clusters of ethnic concentration or segregation effects property markets. This study is significant in its understanding of the main characteristics of ethnic changes of suburbs in Sydney.

Practical implications
An implication is that policy makers can attract different ethnic groups and encourage multicultural communities when they formulate housing and planning policies.

Originality/value
The relationship between ethnicity and house price appreciation is not extensively studied in Australia. This research contributes to the literature on the effects of ethnic changes on house prices and implications of policy formulation to encourage multicultural communities.
A process model for identifying online customer engagement patterns on Facebook brand pages
Authors: Potdar Vidyasagar , Joshi Sujata , Harish Rahul , Baskerville Richard , Wongthongtham Pornpit 
Published: February 2018

PurposeThe purpose of this paper is to develop and empirically test a process model (comprising of seven dimensions), for identifying online customer engagement patterns leading to recommendation. These seven dimensions are communication, interaction, experience, satisfaction, continued involvement, bonding, and recommendation.Design/methodology/approachThe authors used a non-participant form of netnography for analyzing 849 comments from Australian banks Facebook pages. High levels of inter-coder reliability strengthen the study’s empirical validity and ensure minimum researcher bias and maximum reliability and replicability.FindingsThe authors identified 22 unique pattern of customer engagement, out of which nine patterns resulted in recommendation/advocacy. Engagement pattern communication-interaction-recommendation was the fastest route to recommendation, observed in nine instances (or 2 percent). In comparison, C-I-E-S-CI-B-R was the longest route to recommendation observed in ninety-six instances (or 18 percent). Of the eight patterns that resulted in recommendation, five patterns (or 62.5 percent) showed bonding happening before recommendation.Research limitations/implicationsThe authors limited the data collection to Facebook pages of major banks in Australia. The authors did not assess customer demography and did not share the findings with the banks.Practical implicationsThe findings will guide e-marketers on how to best engage with customers to enhance brand loyalty and continuously be in touch with their clients.Originality/valueMost models are conceptual and assume that customers typically journey through all the stages in the model. The work is interesting because the empirical study found that customers travel in multiple different ways through this process. It is significant because it changes the way the authors understand patterns of online customer engagement.
Managers’ perception of mobile technology adoption in the Life Insurance industry
Authors: Naicker Visvanathan , Van Der Merwe Derrick Barry 
Published: February 2018

Purpose
The purpose of this paper is to examine the factors that influence the adoption of mobile technology by considering the information technology (IT) managers’ perception. The research identified the key challenges managers faced and whether management would adopt mobile technology or not.

Design/methodology/approach
A quantitative approach was used for this research, whereby an explanatory research was utilised. Questionnaires were developed and distributed to respondents who were in management and leadership positions and who were responsible for IT within their organisations. Demographic variables of age, gender differences, level of education, level of experience and culture were tested for association to the perceived factors and adoption. A χ2 of association was used to test the association between demographic variables and mobile technology adoption.

Findings
The results found that perceived ease of use, perceived usefulness, perceived complexity and perceived cost are important factors for adoption. However, perceived risk was a key factor in the adoption of mobile technology. Mobile strategy adoption must consider perceived risk factors central to the adoption. The younger generation (20 to 40) years found it easier to adopt technology than the older generation of 41 years and older. Individuals with a post matriculation level of education understood the importance of risk and cost required for adoption.

Research limitations/implications
Purposive sampling from a single industry (Life Insurance) was used. Limited literature was available regarding managers perception of mobile technology adoption in the Life Insurance industry.

Practical implications
The research offers managers insight into the important factors that need to be considered in adopting mobile technology.

Originality/value
With mobile technology being pervasive, the research seeks to provide managers with the insight in managing the adoption of the technology.
The behavioural response of the professional buyer on social cues from the vendor and how to measure it
Authors: van Zeeland Eveline , Henseler Jörg 
Published: February 2018

PurposeVendors’ social cues – physical or behavioural hints – have an impact on the professional buyer. However, little is known about that impact. The purpose of this paper is to place knowledge about the impact of social cues that other disciplines acquired in the context of business-to-business (B2B) marketing to contribute constructively to the research agenda.Design/methodology/approachBy integrating findings on the processing of social cues and the behavioural response from the disciplines of neuroscience, biology and psychology (specifically the behavioural inhibition system [BIS]/behavioural activation system [BAS]-theory), this paper aims to provide an interdisciplinary perspective on the automatic evaluation of vendors by professional buyers.FindingsSocial cues are likely to be of substantial value in the (first) encounter between buyer and seller. Positively evaluated social cues create an approach-motivated behavioural intention, whereas negatively evaluated ones create avoidance. This process is probably predominantly mediated by trust and moderated by personality and contextual factors.Research limitations/implicationsThis paper stimulates research about the impact of social cues in a B2B context. While such knowledge would add practical value, this paper also explores possibilities for managers to use neuroscientific techniques to assess and train sales agents.Originality/valueThe impact of social cues is hardly covered in the B2B marketing literature, but they have an important impact on B2B decision-making. The conceptual framework combines the BIS/BAS theory (approach/avoidance) with the SOR-model (stimulus-organism-response), which is unique to the B2B marketing field.
Sexual aggression in sport
Authors: Carter Daniel Mark , Khan Roxanne , Brewer Gayle 
Published: February 2018

Purpose
The purpose of this paper is to provide an overview of the sexual aggression in sport literature, including an analysis of interventions delivered to athletes that focus on the role of the coach and wider sporting community. The paper will also discuss the limitations of applying such prevention methods and possible directions for future research.

Design/methodology/approach
This paper provides an overview of research investigating the prevalence of sexually aggressive behaviour perpetrated by athletes, theoretical explanations of their sexual misconduct, and the application of violence prevention methods delivered to athletes.

Findings
Research findings are discussed in relation to the prevalence of sexual aggression in sport and the efficacy of prevention methods.

Originality/value
This is a viewpoint piece on sexual aggression in sport.
Knowledge sharing through enterprise social network (ESN) systems: motivational drivers and their impact on employees’ productivity
Authors: Aboelmaged Mohamed Gamal 
Published: February 2018

PurposeThis study aims to predict the impact of utilitarian and hedonic motivations on using enterprise social network (ESN) systems for sharing internal and external knowledge, as well as their effects on employee productivity.Design/methodology/approachResponses of 115 ESN system users from a wide spectrum of firms have been validated and analysed by means of structural equation modelling using partial least squires (PLS-SEM) method.FindingsThe results indicate that using ESN to share internal and external knowledge has a positive significant impact on employee productivity. Surprisingly, empirical analysis reveals that using ESN tends to be significantly influenced by hedonic rather than utilitarian motivations.Originality/valueThe study is an early empirical attempt that examines using ESN for knowledge sharing, emphasizing its upstream motivational influence and downstream business impact. It also offers managers and ESN vendors a frame of reference to maximize the use of ESN in the workplace to boost employees’ productivity within various contexts.
Low carbon supply chain: a state-of-the-art literature review
Authors: Das Chiranjit , Jharkharia Sanjay 
Published: February 2018

PurposeThe purpose of this paper is to review the relevant literature on low carbon supply chain management (LCSCM) and classify it on contextual base. It also aims at identifying key decision-making issues in LCSCM. This paper also highlights some of the future challenges and scope of research in this domain.Design/methodology/approachA content analysis is carried out by systematically collecting the literature from major academic sources over a period of 18 years (2000-2017), identifying structural dimensions and classifying it on contextual base.FindingsThere is an increasing trend of research on LCSCM, but this research is still in a nascent stage. All supply chain functions such as supplier selection, inventory planning, network design and logistic decisions have been redefined by integrating emissions-related issues.Research limitations/implicationsLimitation of this study is inherent in its unit of analysis. Only peer-reviewed journal articles published in English language have been considered in this study.Practical implicationsFindings of prior studies on low carbon inventory control, transportation planning, facility allocation, location selection and supply chain coordination have been highlighted in this study. This will help supply chain practitioners in decision making.Originality/valueThough there are an increasing number of studies about carbon emission-related issues in supply chain management, the present literature lacks to provide a review of the overarching publications. This paper addresses this gap by providing a comprehensive review of literature on emissions-related issues in supply chain management.