bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence for an oncogenic role of HOXC6 in human non-small cell lung cancer
Authors: Yang Yingcheng , Tang Xiaoping , Song Xueqin , Tang Li , Cao Yong , Liu Xu , Wang Xiaoyan , Li Yan , Yu Minglan , Wan Haisu , Chen Feng 
Published: April 2019

Background
Identification of specific biomarkers is important for the diagnosis and treatment of non-small cell lung cancer (NSCLC). HOXC6 is a homeodomain-containing transcription factor that is highly expressed in several human cancers; however, its role in NSCLC remains unknown.

Methods
The expression and protein levels of HOXC6 were assessed in NSCLC tissue samples by Quantitative real-time PCR (qRT-PCR) and immunohistochemistry, respectively. HOXC6 was transfected into the NSCLC cell lines A549 and PC9, and used to investigate its effect on proliferation, migration, and invasion using CFSE, wound healing, and Matrigel invasion assays. Next-generation sequencing was also used to identify downstream targets of HOXC6 and to gain insights into the molecular mechanisms underlying its biological function.

Results
HOXC6 expression was significantly increased in 66.6% (20/30) of NSCLC tumor samples in comparison to normal controls. HOXC6 promoted proliferation, migration, and invasion of NSCLC cells in vitro. RNA-seq analysis demonstrated the upregulation of 310 and 112 genes in A549-HOXC6 and PC9-HOXC6 cells, respectively, and the downregulation of 665 and 385 genes in A549-HOXC6 and PC9-HOXC6 cells, respectively. HOXC6 was also found to regulate the expression of genes such as CEACAM6, SPARC, WNT6, CST1, MMP2, and KRT13, which have documented pro-tumorigenic functions.

Discussion
HOXC6 is highly expressed in NSCLC, and it may enhance lung cancer progression by regulating the expression of pro-tumorigenic genes involved in proliferation, migration, and invasion. Our study highlighted the oncogenic potential of HOXC6, and suggests that it may be a novel biomarker for the diagnosis and treatment of NSCLC.
From climate zone to microhabitat—environmental factors affecting the coastal distribution of tiger beetles (Coleoptera: Cicindelidae) in the south-eastern European biodiversity hotspot
Authors: Jaskuła Radomir , Płóciennik Mateusz , Schwerk Axel 
Published: April 2019

BackgroundTiger beetles (Coleoptera: Cicindelidae) are predatory insects usually occurring in various sandy habitats. In south-eastern Europe, especially in lowland areas located close to the sea coast, the diversity of Cicindelidae is one of the highest in the Palaearctic realm. Although previous studies conducted in different areas of the world show that many species are habitat specialists, unfortunately little is known about environmental factors affecting the diversity and distribution of tiger beetles in this region.Material and MethodsHabitat preferences for 12 tiger beetles taxa were analysed. Over 100 samples collected in eight countries located in coastal areas of the Black and Mediterranean Seas were studied, for which climate data, macrohabitat types, and soil parameters (soil humidity, salinity, pH, and structure) were investigated.ResultsMost studied Cicindelidae were characterised by narrow or very narrow habitat specialisation and did not co-occur with other ones, including 11 taxa found as habitat specialists occurring only in one or two types of macrohabitat. The most eurythopic species wasCalomera littoralis nemoraliswhich occupied four macrohabitat types. The climatic zone, altitude, and humidity were found as the most important factors in the distribution of the studied tiger beetle species. Salt marshes and sandy sea beaches were noted as the most diverse macrohabitat types.DiscussionTiger beetle fauna of south-eastern Europe consists mainly of habitat specialists sensitive to environmental changes, which makes these beetles perfect bioindicators. Moreover, as a great number of studied Cicindelidae taxa occur in habitats which are under a significant human impact, we suggest that in the studied area the group can be successfully used as a flagship taxon for insect and nature conservation.
Improving metacognition: A comparison of interventions
Authors: Saenz Gabriel D. , Geraci Lisa , Tirso Robert 
Published: April 2019

SummaryAccurate knowledge monitoring is critical to the learning process, as it allows one to regulate studying and test preparation. Thus, a number of investigations have attempted to improve metacognition in the classroom, with the ultimate goal of improving student exam performance. However, such interventions have had inconsistent success using varying paradigms. We compared the effectiveness of five interventions aimed at improving prediction accuracy in a laboratory environment: review, salient feedback, motivation warning lecture, incentives, and reflection. Only the salient feedback and the motivation warning lecture interventions significantly improved participants' prediction accuracy from test 1 to test 2. Review, incentives, and reflection did not improve predictive or postdictive calibration. Well‐timed salient feedback and a lecture warning students not to be biased by desired grades were effective methods of improving calibration accuracy. Results offer effective interventions to improve metacognition that could be used in a classroom setting.
Parent‐reported prevalence of food allergies in children with autism spectrum disorder: National health interview survey, 2011–2015
Authors: Tan Yuling , Thomas Shiny , Lee Brian K. 
Published: April 2019

Food allergies are frequently reported to co‐occur with autism spectrum disorder (ASD), but the prevalence of this co‐occurrence remains uncertain. In the present study, we examined parent‐reported prevalence of co‐occurring food allergy and ASD in a nationally representative sample of US children ages 2–17 in the National Health Interview Survey, study years 2011–2015. All analyses used survey weights to account for the complex sampling design. In the analytic sample of 53,365 children ages 2–17, there were 905 children with parent‐reported ASD (prevalence of 1.7%) and 2,977 children with parent‐reported food allergy (prevalence of 5.6%). Parent‐reported food allergies were nearly 2.5 times more common in children with ASD (prevalence of 13.1%) than in children without ASD (5.4%). These results indicate that food allergies commonly co‐occur with ASD, which may have etiological implications. Autism Research 2019, 12: 802–805. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryFood allergies are frequently reported to occur with autism spectrum disorder (ASD), but the prevalence of this co‐occurrence remains uncertain. In the present study, we examined parent‐reported prevalence of co‐occurring food allergy and ASD in a nationally representative sample of United States children. In the sample of 53,365 children ages 2–17, 1.7% of children were reported to have ASD, and 5.6% were reported to have food allergies. Parent‐reported food allergies were nearly 2.5 times more common in children with ASD (13.1%) than in children without ASD (5.4%).
Dynamic Profile Monitoring for Flooding Prognosis in Packed Columns
Authors: Liu Yi , Hseuh Bo-Fan , Gao Zengliang , Wong David Shan Hill , Yao Yuan 
Published: April 2019

AbstractIn the chemical industry, real‐time flooding prognosis is a necessity for packed‐column operation because the flooding phenomenon interferes with the performance of production systems. In this work, the profile monitoring technique is utilized to capture the dynamic behavior of pressure drop, which is an important indicator for the flooding phenomenon. In each moving window, the pressure drop signals are described by using an exponential generalized autoregressive conditional heteroskedastic model. The onset of the flooding phenomenon is then indicated by changes in model parameters. Moreover, to efficiently capture the process change, a nonparametric approach is utilized to establish a statistical control chart. Experimental and comparison results show the advantages of the proposed method.
Probing the Hydrogen Evolution Reaction and Charge Transfer on Platinum Electrodes on Femtosecond Timescales
Authors: Zwaschka G. , Tong Y. , Wolf M. , Kramer Campen R. 
Published: April 2019

AbstractDespite much study, the mechanism of the hydrogen evolution reaction (HER) on Pt is still controversial. Part of the challenge is that any comprehensive mechanism may have to describe processes on timescales from femtoseconds (interfacial electron transfer) to milliseconds (ion diffusion). Here we separate these timescales using a femtosecond perturbation approach: we collect cyclic voltammograms from several Pt electrodes with and without femtosecond laser irradiation. We find that laser irradiation at biases near hydrogen evolution lowers the barrier for H2 generation, while in the H under potential deposition range it induces partial charge transfer along the Pt−H bond and interfacial dipole (re)arrangement. The trend in ultrafast partial charge transfer we measure,
microelectrode, is the same as for H2 generation suggesting insight into both ultrafast electron transfer and slow double layer structural change is required to describe the HER mechanism.
A Series of Dibenzofuran‐Based n‐Type Exciplex Host Partners Realizing High‐Efficiency and Stable Deep‐Red Phosphorescent OLEDs
Authors: Ito Takashi , Sasabe Hisahiro , Nagai Yuji , Watanabe Yuichiro , Onuma Natsuki , Kido Junji 
Published: April 2019

AbstractInvited for the cover of this issue is Hisahiro Sasabe, Junji Kido, and co‐workers at Yamagata University in Japan. The image depicts that highly efficient and stable deep red illumination significantly facilitates plant growth. Read the full text of the article at 10.1002/chem.201805907.
Hydrodynamic Instabilities of Adhering Droplets Due to a Shear Flow in a Rectangular Channel
Authors: Barwari Beawer , Burgmann Sebastian , Janoske Uwe 
Published: April 2019

AbstractThis paper reports on the hydrodynamic droplet instabilities of different sizes and viscosities due to shear forces in a rectangular channel. Water‐glycerine droplets of different volumes are investigated. A new and nonambiguous definition for the critical velocity of droplet detachment and a new mathematical correlation between the critical velocity vcrit and the fluid properties are presented. The measurements show that vcrit decreases with the droplet volume but at the same time the contour deformation increases. With increasing viscosity of the liquid droplet, i.e., higher glycerine mass fraction, the contour deformation becomes more prominent and an increase in vcrit can be observed. With respect to the fluid properties and droplet volumes, three different motion patterns are detected.
Promotive Effect of Bicarbonate Ion on Two‐Electron Water Oxidation to Form H2O2 Catalyzed by Aluminum Porphyrins
Authors: Kuttassery Fazalurahman , Sebastian Abin , Mathew Siby , Tachibana Hiroshi , Inoue Haruo 
Published: April 2019

AbstractTwo‐electron water oxidation initiated by one‐electron oxidation of aluminum porphyrins (AlTMPyP) is an alternative water oxidation to the conventional four‐electron pathway and could help to avoid the bottleneck subject of photon‐flux density in artificial photosynthesis. Here, a dramatic enhancement of the reactivity by bicarbonate ion in the two‐electron water oxidation to form H2O2 is reported. An addition of sodium carbonate (Na2CO3) controlled both catalytic current and product selectivity of the two‐electron water oxidation to enhance the activity of AlTMPyP at pH≈10–11. Controlled potential electrolysis experiments at different concentrations of Na2CO3 (10–100 mm) showed that peroxide selectivity was improved up to approximately 73 % by the increase of [Na2CO3] added to the system. The promotion of the reaction cycle was induced by an enhanced dynamic capturing of H2O2 from the hydroperoxy complex of AlTMPyP through an attack of a bicarbonate ion. The detailed electrochemical studies and product selectivity indicated that the bicarbonate ion served as a good cofactor for producing H2O2 from water. At stronger alkaline conditions (pH 12.5), however, a retardative effect of the addition of Na2CO3 on the catalytic reactivity was observed.
Synthesis, characterization, molecular docking evaluation, antidepressant, and anti‐Alzheimer effects of dibenzylidene ketone derivatives
Authors: Bashir Muhammad Adnan , Khan Arif‐ullah , Badshah Haroon , Rodrigues‐Filho Edson , Din Zia Ud , Khan Aslam 
Published: April 2019

AbstractNovel bioactive compounds as synthetic analogs of the potent herbal medicines can be optimized as potential drug candidates for various neurologic disorders. This study was performed to investigate the newly synthesized dibenzylidene ketone derivatives: (2E,6E)‐2,6‐dibenzylidene cyclohexanone (A1K1) and (1E,4E)‐5‐(2,3‐dichlorophenyl)‐1‐(4‐methoxyphenyl)‐2‐methylpenta‐1,4‐diene‐3‐one (A2K2) and evaluate its potential anti‐Alzheimer's and anti‐depressant properties. Both the derivatives are chemically characterized by using HNMR and CNMR techniques. Auto Dock Vina program was used to investigate ligand‐protein affinity. Forced swim test, tail suspension test, open field test, Y‐maze test, and Morris water maze test (MWM) models were employed to evaluate anti‐depressant and anti‐Alzheimer's activity of dibenzylidene ketone derivatives in mice. Both A1K1 and A2K2 showed high binding affinities against various proteins involved in depression and Alzheimer's mechanisms like monoamine oxidase B, acetylcholinesterase, norepinephrine transporter 2, serotonin transporter, dopamine receptor, serotonin receptor modulator, and beta‐amyloid targets. A1K1 and A2K2 dose‐dependently (0.1–1 mg/kg) decreased immobility time, while increased swimming and climbing time of mice in forced swim test (FST). A1K1 and A2K2 decreased animal immobility time in TST. In the open field test, both A1K1 and A2K2 increased the number of ambulations and rearings. A1K1 and A2K2 dose‐dependently (0.5–1.0 mg/kg) increased spontaneous alternation behavior (%) and the number of entries of mice in Y‐maze test. In the MWM test, A1K1 and A2K2 decreased escape latency time. Overall, both in‐silico and in‐vivo investigations of A1K1 and A2K2, report their therapeutic potential for antidepressant and anti‐Alzheimer properties. Hence, these compounds possess potent neuroprotective properties and may be further evaluated for their therapeutic potential in various neurological disorders.
Mixed‐severity wildfire and habitat of an old‐forest obligate
Authors: Lesmeister Damon B. , Sovern Stan G. , Davis Raymond J. , Bell David M. , Gregory Matthew J. , Vogeler Jody C. 
Published: April 2019

AbstractThe frequency, extent, and severity of wildfire strongly influence the structure and function of ecosystems. Mixed‐severity fire regimes are the most complex and least understood fire regimes, and variability of fire severity can occur at fine spatial and temporal scales, depending on previous disturbance history, topography, fuel continuity, vegetation type, and weather. During high fire weather in 2013, a complex of mixed‐severity wildfires burned across multiple ownerships within the Klamath‐Siskiyou ecoregion of southwestern Oregon where northern spotted owl (Strix occidentalis caurina) demographics were studied since 1990. A year prior to these wildfires, high‐resolution, remotely sensed forest structural information derived from light detection and ranging (lidar) data was acquired for an area that fully covered the extent of these fires. To quantify wildfire impact on northern spotted owl nesting/roosting habitat, we fit a relative habitat suitability model based on pre‐fire locations used for nesting and roosting, and forest structure variables developed from 2012 lidar data. Our pre‐fire habitat suitability model predicted nesting/roosting locations well, and variable response functions followed known resource selection patterns. These forests had typical characteristics of old‐growth forest, with high density of large live trees, high canopy cover, and complex structure in canopy height. We projected the pre‐fire model onto lidar data collected two months post‐fire to produce a post‐fire suitability map, which indicated that >93% of pre‐fire habitat that burned at high severity was no longer suitable forest for nesting and roosting. We also quantified the probability that pre‐fire nesting/roosting habitat would burn at each severity class (unburned/low, low, moderate, high). Pre‐fire nesting/roosting habitat had lower probability of burning at moderate or high severity compared to other forest types under high burning conditions. Our results indicate that northern spotted owl habitat can buffer the negative effects of climate change by enhancing biodiversity and resistance to high‐severity fires, which are predicted to increase in frequency and extent with climate change. Within this region, protecting large blocks of old forests could be an integral component of management plans that successfully maintain variability of forests in this mixed‐ownership and mixed‐severity fire regime landscape and enhance conservation of many species.
Improving Electrochemical Performance of Carbon Felt Anode by Modifying With Akaganeite in Marine Benthic Microbial Fuel Cells
Authors: Zhao Y.‐G. , Ying M. , Fu Y.‐B. , Chen W. 
Published: April 2019

AbstractEnhancing the electrochemical performance of anode is a critical step for improving the power output of marine benthic microbial fuel cells (BMFCs). An active anode involving the akaganeite (β‐FeOOH)‐coated carbon felt was proposed in present study. Results showed that electrochemical performance of modified anode was significantly improved. The peak current density of oxidation reaction increased from 0.664 to 6.107 A m−2. The exchange current density was improved from 11.75 × 10−3 to 151.36 × 10−3 mA cm−2. Electron transfer resistance decreased from 13.4 to 1.407 Ω, while the surface capacitance dramatically increased. The maximum power density of the BMFCs equipped with modified anode approached to 504.2 mW m−2, 2.3 times higher than that with unmodified anode. Moreover, relative abundance of dissimilatory iron reducing bacteria (DIRB) on the modified anode increased. Finally, a molecule synergetic mechanism containing electrostatic interaction and bacteria recognition between DIRB and β‐FeOOH was proposed to interpret the improvement of modified anode.
A Novel Single Sensor Variable Step Size Maximum Power Point Tracking for Proton Exchange Membrane Fuel Cell Power System
Authors: Harrag A. , Bahri H. 
Published: April 2019

AbstractThis paper proposes a novel single sensor variable step size maximum power point tracking (MPPT) method for proton exchange membrane (PEM) fuel cell. This paper is a first, if modest, attempt to develop a single sensor MPPT for fuel cell systems. The proposed MPPT algorithm uses only one sensor to track the maximum power of PEM fuel system composed of 7 kW proton exchange membrane fuel cell (PEMFC) powering 50 Ω resistive load via a DC–DC boost converter driven using the proposed MPPT. The performances of the proposed controller have been evaluated using the implemented PEM fuel cell power system Matlab/Simulink model using two test scenarios considering temperature and hydrogen pressure variation. Simulation results show that the proposed controller can effectively track the maximum power point using only one sensor which reduces the cost as well as the complexity of the PEM fuel cell power system. Comparative results with the two sensors MPPT show that the two sensors MPPT outperforms the single sensor MPPT regarding the dynamic performances. However, the proposed single sensor MPPT performs better considering the static performances. In addition, the proposed controller reduces drastically the current ripple increasing by the way the fuel cell efficiency and lifetime by reducing the frequent trip due to over‐current and even harmonics.
Effects of nicergoline treatment on regional cerebral blood flow in early Alzheimer's disease
Authors: Im Jooyeon J. , Jeong Hyeonseok , Oh Jin Kyoung , Chung Yong‐An , Song In‐Uk , Lee Kwang‐Soo 
Published: April 2019

AbstractAlzheimer's disease (AD) is associated with reduction of regional cerebral blood flow (rCBF) in various brain regions. Although nicergoline has been used to treat cognitive impairment in various types of dementia, the effect of nicergoline on brain perfusion in AD has not been elucidated. The aim of the study was to examine the effect of nicergoline on rCBF in patients with early AD using technetium‐99m hexamethylpropylene amine oxime single‐photon emission computed tomography (SPECT). For 1.7 years on average, 22 patients with early AD received nicergoline (30 mg twice daily) and acetylcholinesterase inhibitors (AChEI), whereas other 22 patients received AChEI only. All patients underwent assessment of dementia severity and SPECT scans at baseline and follow‐up. We compared baseline rCBF and annual percent change of rCBF between the two groups. There were no significant differences in rCBF between the groups at baseline. Although changes in dementia severity was not statistically different, the annual percent changes of rCBF were higher in the left temporal pole (−0.12 ± 3.95 vs −3.38 ± 3.30, P = 0.002) and middle cingulate gyrus (1.91 ± 3.58 vs −1.34 ± 3.17, P = 0.002) among the nicergoline group. Our study demonstrated that nicergoline treatment combined with AChEI either better preserves or further improves cerebral perfusion in the temporal and cingulate cortices in patients with early AD compared to AChEI treatment alone. These results may indicate potential beneficial effects of nicergoline on brain functions in AD.
Investigation of brain functional connectivity in patients with mild cognitive impairment: A functional near‐infrared spectroscopy (fNIRS) study
Authors: Nguyen Thien , Kim Minhee , Gwak Jeonghwan , Lee Jang J. , Choi Kyu Y. , Lee Kun H. , Kim Jae G. 
Published: April 2019

AbstractThis study examines brain functional connectivity in both cognitively normal seniors and patients with mild cognitive impairment (MCI) to elucidate prospective markers of MCI. A homemade four‐channel functional near‐infrared spectroscopy (fNIRS) system was employed to measure hemodynamic responses in the subjects' prefrontal cortex during a resting state, an oddball task, a 1‐back task, and a verbal fluency task. Brain functional connectivity was calculated as the Pearson correlation coefficients between fNIRS channels. The results show that during the verbal fluency task, while the healthy control (HC) group presents a significantly stronger inter‐hemispheric connectivity compared to intra‐hemispheric connectivity, there is no difference between the inter‐ and intra‐hemispheric connectivity in the MCI group. In addition, a comparison between the MCI and HC connectivity reveals that the MCI group has a statistically higher right and inter‐hemispheric connectivity during the resting state, but a significantly lower left and inter‐hemispheric connectivity during the verbal fluency test. These findings demonstrate the potential of fNIRS to study brain functional connectivity in neurodegenerative diseases.