bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transfollicular delivery of gold microparticles in healthy skin and acne vulgaris, assessed by in vivo reflectance confocal microscopy and optical coherence tomography
Authors: Fuchs Christine S. K. , Ortner Vinzent Kevin , Mogensen Mette , Philipsen Peter Alshede , Haedersdal Merete 
Published: March 2019

IntroductionTopical application of gold microparticles (GMPs) for selective photothermolysis is a recently FDA‐cleared therapy for acne vulgaris. Current evidence indicates the potential of optical imaging to non‐invasively visualize GMPs and describe photothermal tissue effects.ObjectivesTo qualitatively and quantitatively describe GMP delivery in vivo and visualize laser‐mediated thermal effects of GMPs in facial skin of acne patients and healthy participants, using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT).MethodsPatients with facial acne (n = 14), and healthy participants (n = 7) were included. RCM and OCT images were acquired at baseline, after GMP application, and after diode laser exposure. All images were evaluated qualitatively and quantitatively with regards to GMP delivery in skin layers and morphological thermal effects. Lastly, skin biopsies were obtained to compare RCM and OCT findings to histology.ResultsGMPs were delivered equally in healthy participants and acne patients, and in lesional and non‐lesional acne skin. In RCM images, GMPs appeared as hyperreflective aggregates inside hair follicles and eccrine ducts, corresponding to natural skin openings (NSOs). The fraction of NSOs with hyperreflective content increased significantly after GMP application compared to baseline (50–75% increase, P = 8.88 × 10−16). Similarly, in OCT images, GMPs appeared as hyperreflective columns inside hair follicles and were not detected in surrounding skin. GMPs reached a maximum depth of 920 μm (median 300 μm). After laser exposure, RCM and histology revealed selective perifollicular tissue changes around NSOs.ConclusionOptical imaging visualizes GMP delivery and thermal tissue response following laser exposure and enables bedside monitoring of transfollicular microparticle delivery. Lasers Surg. Med. 51:430–438, 2019. © 2019 Wiley Periodicals, Inc.
Junctional adhesion molecule‐A is down‐regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways
Authors: Orlandella Francesca Maria , Mariniello Raffaela Mariarosaria , Iervolino Paola Lucia Chiara , Auletta Luigi , De Stefano Anna Elisa , Ugolini Clara , Greco Adelaide , Mirabelli Peppino , Pane Katia , Franzese Monica , Denaro Maria , Basolo Fulvio , Salvatore Giuliana 
Published: March 2019

AbstractJunctional adhesion molecule A (JAM‐A) is a transmembrane protein that contributes to different biological process, including the epithelial to mesenchymal transition (EMT). Through an EMT profiler array, we explored the molecular players associated with human thyroid cancer progression and identified JAM‐A as one of the genes mostly deregulated. The quantitative real‐time polymerase chain reaction and immunohistochemistry analyses showed that downregulation of JAM‐A occurred in anaplastic thyroid carcinoma (ATC) compared with normal thyroid (NT) and papillary thyroid carcinoma (PTC) tissues and correlated with extrathyroid infiltration, tumor size, and ATC histotype. In ATC cell lines, JAM‐A restoration suppressed malignant hallmarks of transformation including cell proliferation, motility, and transendothelial migration. Accordingly, knockdown of JAM‐A enhanced thyroid cancer cell proliferation and motility in PTC cells. Through the proteome profiler human phospho‐kinase array, we demonstrated that higher expression of JAM‐A was associated with a significant increased level of phosphorylation of p53 and GSK3 α/β proteins. In conclusion, our findings highlight a novel role of JAM‐A in thyroid cancer progression and suggest that JAM‐A restoration could have potential clinical relevance in thyroid cancer treatment.
Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice
Authors: Sasaki Keisuke , Hara Satoshi , Yamakami Reina , Sato Yusuke , Hasegawa Saki , Kono Tomohiro , Morohaku Kanako , Obata Yayoi 
Published: March 2019

AbstractDNA methylation is generally known to inactivate gene expression. The DNA methyltransferases (DNMTs), DNMT3A and DNMT3B, catalyze somatic cell lineage‐specific DNA methylation, while DNMT3A and DNMT3L catalyze germ cell lineage‐specific DNA methylation. How such lineage‐ and gene‐specific DNA methylation patterns are created remains to be elucidated. To better understand the regulatory mechanisms underlying DNA methylation, we generated transgenic mice that constitutively expressed DNMT3A and DNMT3L, and analyzed DNA methylation, gene expression, and their subsequent impact on ontogeny. All transgenic mice were born normally but died within 20 weeks accompanied with cardiac hypertrophy. Several genes were repressed in the hearts of transgenic mice compared with those in wild‐type mice. CpG islands of these downregulated genes were highly methylated in the transgenic mice. This abnormal methylation occurred in the perinatal stage. Conversely, monoallelic DNA methylation at imprinted loci was faithfully maintained in all transgenic mice, except H19. Thus, the loci preferred by DNMT3A and DNMT3L differ between somatic and germ cell lineages.
Heuristics for the strong generalized minimum label spanning tree problem
Authors: Cerrone Carmine , D'Ambrosio Ciriaco , Raiconi Andrea 
Published: March 2019

AbstractIn this work we introduce and study the strong generalized minimum label spanning tree (GMLST), a novel optimization problem defined on edge‐labeled graphs. Given a label set associated to each edge of the input graph, the aim is to look for the spanning tree using the minimum number of labels. Differently from the previously introduced GMLST problem, including a given edge in the solution means that all its labels are used. We present a mathematical formulation, as well as three heuristic approaches to solve the problem. Computational results compare the performances of the proposed algorithms.
A simple explicit single step time integration algorithm for structural dynamics
Authors: Kim Wooram 
Published: March 2019

SummaryIn this article, a new single‐step explicit time integration method is developed based on the Newmark approximations for the analysis of various dynamic problems. The newly proposed method is second‐order accurate and able to control numerical dissipation through the parameters of the Newmark approximations. Explicitness and order of accuracy of the proposed method are not affected in velocity‐dependent problems. Illustrative linear and nonlinear examples are used to verify performances of the proposed method.
Training of NANDA‐I Nursing Diagnoses (NDs), Nursing Interventions Classification (NIC) and Nursing Outcomes Classification (NOC), in Psychiatric Wards: A randomized controlled trial
Authors: Taghavi Larijani Taraneh , Saatchi Babak 
Published: March 2019

AbstractAimTo assess the effect of Training NANDA‐I Nursing Diagnoses, Nursing Interventions Classification and Nursing Outcomes Classification (The NNN system), on the nursing care related to the patient safety, in psychiatric wards.MethodIn a randomized controlled trial, 80 nurses were selected randomly and assigned into two, Control and Experimental, groups. Nurses documented reports, reviewed and analysed in terms of using the NNN system. The intervention of the study was the training of the NNN system, based on recognition of the signs, symptoms and aetiology of the important phenomena in the psychiatric wards.ResultsThe Control Group used the NNN system (N = 34), both before and after the intervention, while the experimental group usage increased from (N = 26)–(N = 434). Therefore, the NNN system training, can improve the nursing care related to the patient safety in psychiatric wards.
Promoting self‐management of breast and nipple pain in breastfeeding women: Protocol of a pilot randomized controlled trial
Authors: Lucas Ruth , Bernier Katherine , Perry Mallory , Evans Heather , Ramesh Divya , Young Erin , Walsh Stephen , Starkweather Angela 
Published: March 2019

AbstractThe majority of women experience pain during breastfeeding initiation with few strategies to manage breast and nipple pain. In fact, women cite breast and nipple pain as among the most common reasons for breastfeeding cessation. To address this important issue, we developed a breastfeeding self‐management (BSM) intervention, based on the Individual and Family Self‐Management Theory Framework. In this framework, self‐management is conceptualized as a process in which women use knowledge, beliefs, and social facilitation to achieve breastfeeding goals. The purpose of this longitudinal pilot randomized controlled trial was to test the feasibility, acceptability, and preliminary efficacy of the BSM intervention with women initiating breastfeeding. Recruitment of 60 women intending to breastfeed occurred within 48 hr of delivery and women were randomized to either the intervention or usual care group. The BSM intervention group received BSM education modules that included information of how to manage breast and nipple pain and self‐management support through biweekly texting from the study nurse, and were asked to complete a daily breastfeeding journal. Primary outcomes measured at baseline, 1, 2, and 6 weeks will be used to (a) evaluate feasibility, acceptability, and preliminary efficacy of the BSM intervention, and (b) assess the influence of protective and risk factors of breastfeeding pain (including individual genetic polymorphisms related to pain sensitivity) on process variables for self‐management of breastfeeding and breastfeeding pain, and on proximal (breastfeeding pain severity and interference, breastfeeding frequency) and distal outcomes (breastfeeding exclusivity and duration and general well‐being).
Synthesis of a novel oil‐absorption resin and optimization of its performance parameters using response surface design
Authors: Kong Lingtong , Ma Lei , Jin Haibo , Hou Jing , He Guangxiang , Zhang Rongyue 
Published: March 2019

A novel porous oil absorbing resin with the main monomers of stearyl methacrylate and isooctyl methacrylate was synthesized using suspension polymerization. The synthesis experiments were conducted using the response surface design method. And the influences of initiator concentration, cross‐linker concentration, and dispersant concentration were investigated. Through analyzing the second‐order polynomial mathematical models and the corresponding data, the mutual effects between these factors on the oil‐absorption performance were obtained. The response surface was used to analyze the oil (gasoline, diesel, and kerosene) absorption performance in the pure oil samples and oily water samples, respectively. The content of initiator and cross‐linker exhibited a necessary effect on the absorption of gasoline and kerosene. Moreover, the two most significant factors for diesel are the amount of initiator and dispersant. The experimental results showed that the oil‐absorbing resin synthesized under the optimized condition could achieve better oil‐absorption rate on all three oils. The absorption rates of gasoline, diesel, and kerosene are 10.14, 10.73, and 11.69 g/g, respectively, which the deoiling rate can reach closed 100% in the water sample containing gasoline and kerosene.
Effects of silymarin supplementation on blood lipids: A systematic review and meta‐analysis of clinical trials
Authors: Mohammadi Hamed , Hadi Amir , Arab Arman , Moradi Sajjad , Rouhani Mohammad Hossein 
Published: March 2019

Dyslipidemia is a leading cause of endothelial dysfunction and cardiovascular disease. Several studies used silymarin as an herbal supplement in hyperlipidemic subjects. The aim of the present systematic review and meta‐analysis was to examine the effect of silymarin supplementation on blood lipids. PubMed, Scopus, Ovid (Cochrane library), ISI Web of Science, and Google Scholar were systematically searched until March 2018 to find intervention studies that examined the impact of silymarin supplementation on blood lipids in adults. Changes in blood lipids and potential sources of between‐study variation were extracted. We run a subgroup analysis to determine potential sources of inter‐study heterogeneity. Ten clinical trials fulfilled the eligibility criteria. Meta‐analysis indicated that silymarin supplementation in combination with other treatments (not silymarin alone) reduced total cholesterol (change: −25.45 mg/dl; 95% confidence interval [CI] [−47.89, −3.01 mg/dl]) and low‐density lipoprotein (change: −28.25 mg/dl; 95% CI [−53.09, −3.42 mg/dl]). Also, silymarin increased high‐density lipoprotein concentration (change: 4.82 mg/dl; 95% CI [2.01, 7.63 mg/dl]). Blood concentration of triglyceride was significantly after silymarin supplementation in comparison with controls (change: −22.55 mg/dl; 95% CI [−44.32, −0.78 mg/dl]). Present systematic review and meta‐analysis revealed that silymarin supplementation in combination with other treatments had a favorable effect on blood lipids.
Average dwell time based stability analysis for nonautonomous continuous‐time switched systems
Authors: Lu Junjie , She Zhikun 
Published: March 2019

SummaryInspired by the idea of multiple Lyapunov functions and the average dwell time, we address the stability analysis of nonautonomous continuous‐time switched systems. First, we investigate nonautonomous continuous‐time switched nonlinear systems and successively propose sufficient conditions for their (uniform) stability, global (uniform) asymptotic stability, and global (uniform) exponential stability, in which an indefinite scalar function is utilized to release the nonincreasing requirements of the classical multiple Lyapunov functions. Afterwards, by using multiple Lyapunov functions of quadratic form, we obtain the corresponding sufficient conditions for (uniform) stability, global (uniform) asymptotic stability, and global exponential stability of nonautonomous switched linear systems. Finally, we consider the computation issue of our current results for a special class of nonautonomous switched systems (ie, rational nonautonomous switched systems), associated with two illustrative examples.
Stochastic stability and extended dissipativity analysis for uncertain neutral systems with semi‐Markovian jumping parameters via novel free matrix–based integral inequality
Authors: Wu Tao , Xiong Lianglin , Cao Jinde , Zhang Haiyang 
Published: March 2019

SummaryThis paper investigates the issues of stochastic stability and extended dissipativity analysis for uncertain neutral systems with semi‐Markovian jumping parameters. A new criterion about the stochastic stability and extended dissipativity of uncertain neutral systems with semi‐Markovian jumping parameters is obtained based on the new Lyapunov‐Krasovskii functionals together with the introduced novel free matrix–based integral inequality. The major contribution of this study is that the stochastic stability and extended dissipativity concept for uncertain neutral systems with semi‐Markovian jumping parameters can be developed to simultaneously analyze the solutions of the L2 − L∞ performance, H∞ action, passivity behavior, and
dissipativity by selecting different weighting matrices. Finally, several interesting numerical examples are provided to show the effectiveness and less conservatism of the proposed method.
Dynamic intermittent Q‐learning–based model‐free suboptimal co‐design of ‐stabilization
Authors: Yang Yongliang , Vamvoudakis Kyriakos G. , Ferraz Henrique , Modares Hamidreza 
Published: March 2019

SummaryThis paper proposes an intermittent model‐free learning algorithm for linear time‐invariant systems, where the control policy and transmission decisions are co‐designed simultaneously while also being subjected to worst‐case disturbances. The control policy is designed by introducing an internal dynamical system to further reduce the transmission rate and provide bandwidth flexibility in cyber‐physical systems. Moreover, a Q‐learning algorithm with two actors and a single critic structure is developed to learn the optimal parameters of a Q‐function. It is shown by using an impulsive system approach that the closed‐loop system has an asymptotically stable equilibrium and that no Zeno behavior occurs. Furthermore, a qualitative performance analysis of the model‐free dynamic intermittent framework is given and shows the degree of suboptimality concerning the optimal continuous updated controller. Finally, a numerical simulation of an unknown system is carried out to highlight the efficacy of the proposed framework.
Investigation on Trimethylamine Sensing Performance of PdO‐Decorated ZnO Flower‐Like Structures Synthesized by One‐ Step Hydrothermal Method
Authors: San Xiaoguang , Liu Dongyu , Wang Guosheng , Shen Yanbai , Meng Dan , Meng Fanli 
Published: March 2019

AbstractZnO and PdO‐decorated ZnO flower‐like structures have been synthesized using a facile one‐step hydrothermal method followed by subsequent calcination. Then, their structural information and trimethylamine (TMA) sensing performance were investigated. The results exhibited that the diameter of these ZnO flower‐like structures was in the range of 3–7 μm. Its morphology was maintained after introducing PdO nanoparticales. By comparing the sensing properties, it is found that sensors based on PdO‐decorated ZnO flower‐like structures showed higher TMA response than that of pure one. Especially, the sensor fabricated by 1 mol% PdO‐decorated ZnO flower‐like structures displayed superior gas sensing performances including high response, rapid response/recover characteristics, good stability, and high selectivity. Such a superior sensing performance is mainly due to the chemical and electrical sensitization of PdO nanoparticles. This simple synthesis strategy and a desirable TMA sensing performance could be broadly developed other metallic doped metal oxide flower‐like structures as high performance sensing materials.
Thin Carbon Layer Coated Porous Fe3O4 Particles Supported by rGO Sheets for Improved Stable Sodium Storage
Authors: Qi Hui , Cao Liyun , Li Jiayin , Huang Jianfeng , Xu Zhanwei , Jie Yanni , Wang Caiwei 
Published: March 2019

AbstractIron oxide (Fe3O4) is considered as a promising sodium ion anode material due to high capacity, low cost and nontoxic features. However, the main challenges associated with Fe3O4 anodes are structure instability and low initial Coulombic efficiency (∼50%) during charge/discharge process. In this work, thin carbon layer (∼2.5 nm) coated porous Fe3O4 particles (∼ 100 nm) anchored on reduced graphene oxide sheets (Fe3O4@C/rGO) are achieved. Fe3O4@C/rGO composite shows a stable cycling performance of 356 mAh g−1 after 300 cycles at 0.1 A g−1 with a slight decay of 0.098 mAh g−1 per cycle. Moreover, it exhibits a high initial Coubombic efficiency of 74%, superior to the values in most reported literatures for Fe3O4/carbon composites. The excellent electrochemical performance is attributed to the porous structure of Fe3O4 which can accommodate the mechanical stress induced by the volume expansion, and the outside carbon layers which can protect Fe3O4 from electrolyte to form a stable solid electrolyte interface film.
Melting the Cultural Iceberg in Indigenizing Higher Education: Shifts to Accountability in Times of Reconciliation
Authors: Vaudrin‐Charette Julie 
Published: March 2019

AbstractIn this chapter, the author draws on personal experiences as pedagogical advisor and as a doctoral student, to consider how recognizing voice, family, and vulnerabilities may assist in developing a sense of accountability in academia. Reflecting on the Canadian context of reconciliation, the author considers how moving from an intercultural to an equity paradigm may melt the cultural iceberg.
Amniotic fluid volume at presentation with early preterm prelabor rupture of membranes and association with severe neonatal respiratory morbidity
Authors: Weiner E. , Barrett J. , Zaltz A. , Ram M. , Aviram A. , Kibel M. , Lipworth H. , Asztalos E. , Melamed N. 
Published: March 2019

ABSTRACTObjectiveAmniotic fluid volume (AFV) plays an important role in early fetal lung development, and oligohydramnios in early pregnancy is associated with pulmonary hypoplasia. The aim of this study was to evaluate the association between AFV at the time of presentation with early preterm prelabor rupture of membranes (PPROM) and severe neonatal respiratory morbidity and other adverse pregnancy outcomes.MethodsThis was a retrospective study of all women with a singleton pregnancy, admitted to a single tertiary referral center between 2004 and 2014, for expectant management of PPROM at 20 + 0 to 28 + 6 weeks' gestation. The primary exposure was AFV at presentation, classified according to sonographic maximum vertical pocket (MVP) as: normal AFV (> 2 cm), oligohydramnios (≤ 2 cm and > 1 cm) or severe oligohydramnios (≤ 1 cm). The primary outcome was a composite variable of severe respiratory morbidity, defined as either of the following: (1) need for respiratory support in the form of mechanical ventilation using an endotracheal tube for ≥ 72 h and need for surfactant; or (2) bronchopulmonary dysplasia, defined as requirement for oxygen at postmenstrual age of 36 weeks or at the time of transfer to a Level‐II facility. Adjusted odds ratios (aOR) and 95% CI for the primary and secondary outcomes were calculated for each AFV‐at‐presentation group (using normal AFV as the reference), adjusting for gestational age (GA) at PPROM, latency period, birth weight, mode of delivery and chorioamnionitis.ResultsIn total, 580 women were included, of whom 304 (52.4%) had normal AFV, 161 (27.8%) had oligohydramnios and 115 (19.8%) had severe oligohydramnios at presentation. The rates of severe respiratory morbidity were 16.1%, 26.7% and 45.2%, respectively. Compared with normal AFV at presentation, oligohydramnios (aOR, 3.27; 95% CI, 1.84–5.84) and severe oligohydramnios (aOR, 4.11; 95% CI, 2.26–7.56) at presentation were associated independently with severe respiratory morbidity. Other variables that were associated independently with the primary outcome were GA at PPROM (aOR, 0.54; 95% CI, 0.43–0.69), latency period (aOR, 0.94; 95% CI, 0.91–0.98) and Cesarean delivery (aOR, 2.01; 95% CI, 1.21–3.32).ConclusionsIn women with early PPROM, AFV at presentation, as assessed by the MVP on ultrasound examination, is associated independently with severe neonatal respiratory morbidity. This information may be taken into consideration when counseling women with early PPROM regarding neonatal outcome and management options. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.