bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synoptic to Microscale Processes Affecting the Evolution of a Cold-Air Pool in a Northern New England Forested Mountain Valley
Authors: Kelsey Eric P. , Cann Matthew D. , Lupo Kevin M. , Haddad Liana J. 
Published: April 2019

AbstractThe formation of katabatic winds and pooling of cold air in mountain valleys impact air quality, precipitation type, and local ecosystem functions. Much is still poorly understood about the multiscale interaction of processes in a mature mixed-hardwood forest that cause the formation and evolution of cold-air pools (CAPs). Processes involved in the evolution of a CAP in the Hubbard Brook Experimental Forest valley in New Hampshire were investigated during a field campaign on 4–5 November 2015. Vertical profiles of temperature and humidity were measured along a 150-m-long tethered balloon in the center of the valley and were compared with temperature and wind observations on the surrounding slopes to identify and assess the impacts of multiscale processes on a CAP. A CAP formed rapidly during the afternoon of 4 November and attained its maximum depth of ~150 m by sunset. This maximum depth is likely a result of the topography of the valley. Warm-air advection (WAA) occurred during the second half of the night at high elevations, and warm air mixed downward into the valley. As a result, the vertical thermal gradient strengthened and static stability increased, which allowed the lowest part of the CAP to continue to radiatively cool while the upper part of the CAP was warmed and eroded by the WAA. Results suggest that the canopy acts as the primary cooling surface for air at night, which causes split katabatic flow: cold and fast flow above canopy and warmer and slower flow below canopy. Understanding these processes in sloped forests has implications for eddy covariance research and montane microclimates.
The pathway for introducing novel examination procedures in routine practice in accordance with ISO 15189:2012: 17-Hydroxy progesterone, dehydroepiandrosterone sulphate and vitamin D as examples
Authors: Antonelli Giorgia , Sciacovelli Laura , Aita Ada , Bozzato Dania , Plebani Mario 
Published: April 2019

Background In a medical laboratory, changes may be made to the analytical phase of diagnostic testing whenever a new test or the issue of a ‘new generation’ kit or new diagnostic system is required. In such cases, ISO 15189:2012 accreditation can assist laboratory professionals. The aim of the present study was to propose a working pathway for introducing new examination procedures into clinical practice in accordance with the ISO 15189:2012 standard, through the exemplars of 17-hydroxy progesterone, dehydroepiandrosterone sulphate and vitamin D. Methods The working pathway includes the following steps: (i) analysing examination procedures under evaluation, (ii) analysing examination procedures currently in use, (iii) verifying metrological traceability, (iv) verifying examination procedures and (v) evaluating comparability of results. Results The analysis of instructions for use issued by manufacturers revealed that metrological traceability was reported only for vitamin D. The imprecision verification was satisfactory, the imprecision obtained by the laboratory in terms of total imprecision always being less than the specified total imprecision. In only one case (IQC level 1, 17-hydroxy progesterone), the total upper verification limit was calculated. The trueness verification was satisfactory for all examination procedures, except for 17-hydroxy progesterone (second material). Passing–Bablok regression analyses in the comparability study demonstrated significant differences for all the examination procedures. Conclusions The working pathway described for examination procedures in routine practice is in accordance with the requirements of ISO 15189:2012 accreditation and takes feasibility into account (as its main goal), based on the cost/patient benefit ratio.
Results of a pilot test of effects of an online resource on lay audience understanding of media reports on breast cancer research
Authors: Yi Robin H Pugh , Rezende Lisa , Dearfield Craig T , Welcsh Piri , Friedman Susan J 
Published: April 2019

Objective: This study aimed to assess the effects of eXamining Relevance of Articles to Young Survivors (XRAYS), an online resource that provides brief articles discussing recent research relevant to young women with or at risk for breast cancer, on users’ knowledge about information covered in media reports. An evaluator also assessed the degree to which XRAYS facilitated awareness of recent research findings and how users recommended improving the resource. Design: Participants were randomly assigned to an intervention condition, whose members read original news reports and the corresponding XRAYS review or to a control condition, whose members read only original news reports. Participants also discussed XRAYS’ utility and cultural appropriateness. Setting: Data were collected in a meeting room at a Facing Our Risk of Cancer Empowered (FORCE) conference. All participants were registered for a conference for women with or at risk for genetic breast or ovarian cancer. Method: Participants answered multiple choice questions about research before reading the assigned materials and again after reading the assigned materials. T-tests were used to assess pre-post-test change for both groups and to compare groups’ change in knowledge. Results: Both groups improved between pre- and post-test. The treatment group increased knowledge significantly more than the control group. Focus group results indicate that XRAYS is a valuable resource for identifying relevant recent research findings and for explaining limitations in research methods, relevance, and reporting quality. Results also indicate that it is critical for XRAYS and similar resources to be brief, use non-technical language and address the most recent trends in media coverage. Conclusion: Online resources that use plain language to help users to interpret science reporting critically help meet an important health education need.
Work motivation in patients with bipolar disorder: Associated factors
Authors: Martínez-Camarillo Sara , Yoldi-Negrete María , Fresán-Orellana Ana , Ortega-Ortiz Hiram , Becerra-Palars Claudia 
Published: April 2019

Background: Occupational functioning is severely impaired in patients with bipolar disorder (BD). Work motivation (WM), defined as the psychological processes that determine the direction, intensity, and persistence of action within the work, is an essential component of work-related functioning. Aim: To assess whether WM is affected in patients with BD and which clinical and sociodemographic factors are related to low WM. Methods: In all, 95 euthymic BD patients were invited to answer the Motivation for Work Questionnaire and the Rating Scale on Subjective Cognitive Deficits in Bipolar Disorder (COBRA). Results: A total of 49.5% ( n = 47) of the patients were classified in the Low Motivated (LM) group. Unemployment and the report of more subjective cognitive complaints were predictors of poor WM in this sample ((OR) = 3.01 and 7.10, respectively). Conclusions: Perceived cognitive deficits related to the disorder and current unemployment negatively impact WM in patients with BD. In addition to symptomatic recovery, the need of the inclusion of personal and occupational areas in the comprehensive treatment of patients with BD is necessary.
Passive-specific immunotherapy with monoclonal antibodies for prostate cancer: A systematic review
Authors: Khalili Neda , Keshavarz-Fathi Mahsa , Shahkarami Sepideh , Hirbod-Mobarakeh Armin , Rezaei Nima 
Published: April 2019

Introduction Treatment of metastatic castration-resistant prostate cancer with conventional therapies is still not successful. Therefore, application of novel biological approaches such as immunotherapy, which appears to be more effective and less toxic, is necessary. Monoclonal antibodies against cancer specific antigens are a kind of immunotherapy that have been approved for specific types of cancer and are being investigated for prostate cancer as well. The aim of this review was to assess the effectiveness and safety of monoclonal antibodies for treatment of advanced prostate cancer. Method According to the search strategy stated in our systematic review protocol, Scopus, Medline, TRIP, CENTRAL, ProQuest, DART and OpenGrey databases were searched. Data collection and quality assessment were done independently by two authors and any disagreements between the collected data were resolved by a third author. A meta-analysis was not feasible as there was a considerable statistical heterogeneity among the trials. Hence, this review was limited to a narrative analysis of the included studies. Results We found 9756 references by applying search strategy in 4 databases of journal articles and 3 databases of grey literature. We then discarded 3957 duplicate citations using Endnote software and 5143 articles due to obvious irrelevancy of their topics in primary screening. In secondary screening of 656 fulltexts, we excluded 538 articles, and finally included 12 trials in this systematic review, updated on 23 June 2017. The overall quality of the studies was fair. In general, results of this systematic review show promising advances in the treatment of prostate cancer patients with monoclonal antibodies against prostate-specific antigens with regard to PSA/disease response. Some of the studies reported pain relief after treatment as well. Conclusion Currently, the role of immunotherapy in the treatment of advanced prostate cancer still remains debated. Although passive specific immunotherapy could be offered as a novel therapeutic option in the coming years, patients should be informed about the risks and benefits of this therapy. One of the obstacles in this review was the lack of adequate assessment of survival-related endpoints reported in the included studies. Our study provides support for further research in this field.
Overexpression of long noncoding RNA LINC01419 in esophageal squamous cell carcinoma and its relation to the sensitivity to 5-fluorouracil by mediating GSTP1 methylation
Authors: Chen Jian-Liang , Lin Zhi-Xiong , Qin Yun-Sheng , She Yu-Qi , Chen Yun , Chen Chen , Qiu Guo-Dong , Zheng Jie-Ting , Chen Zhong-Lin , Zhang Shu-Yao 
Published: April 2019

Background: Genome-wide sequencing investigations have identified numerous long noncoding RNAs (lncRNAs) among mammals, many of which exhibit aberrant expression in cancers, including esophageal squamous cell carcinoma (ESCC). Herein, this study elucidates the role and mechanism by which LINC01419 regulates the DNA methylation of glutathione S-transferase pi 1 (GSTP1) in relation to ESCC progression and the sensitivity of ESCC cells to 5-fluorouracil (5-FU). Methods: LINC01419 and GSTP1 levels were quantified among 38 paired ESCC and adjacent tissue samples collected from patients with ESCC. To ascertain the contributory role of LINC01419 in the progression of ESCC and identify the interaction between LINC01419 and GSTP1 promoter methylation, LINC01419 was overexpressed or silenced, and the DNA methyltransferase inhibitor 5-Aza-CdR was treated. Results: Data from the GEO database (GSE21362) and the Cancer Genome Atlas displayed elevated levels of LINC01419 and downregulated levels of GSTP1 in the ESCC tissues and cells. The silencing of LINC01419 led to decreased proliferation, increased apoptosis, and enhanced sensitivity to 5-FU in ESCC cells. Notably, LINC01419 could bind to the promoter region of the GSTP1 gene, resulting in elevated GSTP1 methylation and reduced GSTP1 levels via the recruitment of DNA methyltransferase among ESCC cells, whereby ESCC progression was stimulated accompanied by reduced ESCC cell sensitivity to 5-FU. GSTP1 demethylation by 5-Aza-CdR was observed to reverse the effects of LINC01419 overexpression in ESCC cells and the response to 5-FU. Conclusion: Highly expressed LINC01419 in ESCC promotes GSTP1 methylation, which ultimately acts to promote the event of ESCC and diminish the sensitivity of ESCC cells to 5-FU, highlighting a novel potential strategy to improve 5-FU-based chemotherapy in ESCC.
Laboratory Evaluation of Linearity, Repeatability, and Hematocrit Interference With an Internet-Enabled Blood Glucose Meter
Authors: Demircik Filiz , Kirsch Valeria , Ramljak Sanja , Vogg Mario , Pfützner Anke H. , Pfützner Andreas 
Published: April 2019

Background: In recent clinical trials, use of the MyGlucoHealth blood glucose meter (BGM) and electronic diary was associated with an unusual reporting pattern of glycemic data and hypoglycemic events. Therefore, the performance of representative BGMs used by the patients was investigated to assess repeatability, linearity, and hematocrit interference in accordance with regulatory guidelines. Method: Ten devices and 6 strip lots were selected using standard randomization and repeatability procedures. Venous heparinized blood was drawn from healthy subjects, immediately aliquoted and adjusted to 5 target blood glucose (BG) ranges for the repeatability and 11 BG concentrations for the linearity tests. For the hematocrit interference test, each sample within 5 target BG ranges was split into 5 aliquots and adjusted to hematocrit levels across the acceptance range. YSI 2300 STAT Plus was used as the laboratory reference method in all experiments. Results: Measurement repeatability or precision was acceptable across the target BG ranges for all devices and strip lots with coefficient of variation (CV) between 3.4-9.7% (mean: 5.7%). Linearity was shown by a correlation coefficient of .991; however, a positive bias was seen for BG <100 mg/dL (86% measurements did not meet ISO15197:2015 acceptance criteria). Significant hematocrit interference (up to 20%) was observed for BG >100 mg/dL (ISO15197:2015 acceptance criteria: ±10%), while the results were acceptable for BG <100 mg/dL. Conclusions: The BGM met repeatability requirements but demonstrated a significant measurement bias in the low BG range. In addition, it failed the ISO15197:2015 criteria for hematocrit interference.
Efficacy and Safety of Degludec Compared to Glargine 300 Units/mL in Insulin-Experienced Patients With Type 2 Diabetes: Trial Protocol Amendment (NCT03078478)
Authors: Philis-Tsimikas Athena , Stratton Irene , Nørgård Troelsen Lone , Anker Bak Britta , Leiter Lawrence A. 
Published: April 2019

Background: A head-to-head trial (NCT03078478) between insulin degludec and insulin glargine U300 with the primary objective of comparing the risk of hypoglycemia is being conducted. During trial conduct, safety concerns related to the glycemic data collection system led to a postinitiation protocol amendment, described here. Methods: This randomized (1:1), open-label, treat-to-target, multinational trial was initiated in March 2017 with a planned treatment period of 52 weeks (16 weeks titration + 36 weeks maintenance). Overall, ~1600 insulin-experienced patients at risk of developing hypoglycemia based on predefined risk factors were included. The protocol amendment implemented in February 2018 resulted in assuring patient safety and an extension of the total treatment period up to 88 weeks (16 weeks titration + variable maintenance 1 + 36 weeks maintenance 2). The original glycemic data collection system (MyGlucoHealth blood glucose meter + electronic diary) was discontinued because of safety concerns and replaced with an Abbott blood glucose meter and paper diary to collect self-measured blood glucose and hypoglycemic episodes. The primary endpoint of number of severe or blood-glucose confirmed symptomatic hypoglycemic episodes will be evaluated with the same analysis duration and statistical methods as the original protocol. Only relevant changes were implemented to maintain patient safety while permitting evaluation of the scientific objectives of the trial. Conclusions: These observations highlight the importance of safety surveillance during trial conduct despite the use of currently marketed glucose monitoring devices. The prompt protocol amendment and ensuing actions ensured that the scientific integrity of the trial was not compromised.
Incremental costs of high intensive care utilisation in patients hospitalised with heart failure
Authors: van Diepen Sean , Tran Dat T , Ezekowitz Justin A , Schnell Gregory , Wiley Brandon M , Morrow David A , McAlister Finlay A , Kaul Padma 
Published: April 2019

Aims: Registries have reported large inter-hospital differences in intensive care unit admission rates for patients with acute heart failure, but little is known about the potential economic impact of over-admission of low-risk patients with heart failure to higher cost intensive care units. We described the variability in intensive care unit admission practices, the provision of critical care therapies, and estimated the potential national cost savings if all hospitals adopted low intensive care unit admission practices for patients admitted with heart failure. Methods: Using a national population health dataset, we identified 349,693 heart failure admission hospitalisations with a primary diagnosis of heart failure between 2007 and 2016. Hospitals were categorised as low (first quartile), medium (second and third quartile) and high (fourth quartiles) intensive care unit utilisation. Results: The mean intensive care unit admission rate was 16.4% (inter-hospital range 0.3–51%) including 5.4% in low, 14.5% in medium and 30% in high utilisation hospitals. Intensive care unit therapies in low, medium and high intensive care unit utilisation hospitals were 54.5%, 45.1% and 24.1% ( P<0.001), respectively and the inhospital mortality rate was not significantly different. The proportion of hospital costs incurred by intensive care unit care was 7.8% in low, 19.8% in medium and 28.2% in high ( P<0.001) admission hospitals. The potential cost savings of altering intensive care unit utilisation practices for patients with heart failure was CAN$234.8m over the study period. Conclusions: In a national cohort of patients hospitalised with heart failure, we observed that low intensive care unit utilisation centres had lower hospital costs with no differences in mortality rates. The development of standardised admission criteria for high-cost and high acuity intensive care unit beds could reduce costs to the healthcare system.
Antofagastaite, Na2Ca(SO4)2·1.5H2O, a new mineral related to syngenite
Authors: Pekov Igor V. , Kovrugin Vadim M. , Siidra Oleg I. , Chukanov Nikita V. , Belakovskiy Dmitry I. , Koshlyakova Natalia N. , Yapaskurt Vasiliy O. , Turchkova Anna G. , Möhn Gerhard 
Published: April 2019

AbstractThe new mineral antofagastaite, ideally Na2Ca(SO4)2·1.5H2O, was found in the oxidation zone of sulfide–quartz veins at the abandoned Coronel Manuel Rodríguez mine, Mejillones, Antofagasta Province, Antofagasta Region, Chile. It is associated with sideronatrite, metasideronatrite, aubertite, gypsum, ferrinatrite, glauberite, amarillite and an unidentified Fe phosphate. Antofagastaite occurs as prismatic crystals up to 0.5 mm × 1 mm × 5 mm, elongated along [010], typically combined in open-work aggregates up to 1 cm across. Antofagastaite is transparent and colourless, with vitreous lustre. It is brittle; the Mohs’ hardness isca3. Cleavage is distinct on (001).Dmeas.is 2.42(1) andDcalc.is 2.465 g cm−3. Antofagastaite is optically biaxial (–), α = 1.489(2), β = 1.508(2), γ = 1.510(2) and 2Vmeas.= 40(10)°. The IR spectrum is reported. Chemical composition (wt.%, electron microprobe, H2O determined by gas chromatography) is: Na2O 20.85, CaO 17.42, SO352.56, H2O 7.93, total 98.76. The empirical formula (based on 8 O atoms belonging to sulfate anions per formula unit with all H belonging to H2O molecules) is Na2.06Ca0.95S2.01O8·1.35H2O. Antofagastaite is monoclinic,P21/m,a= 6.4596(4),b= 6.8703(5),c= 9.4685(7) Å, β = 104.580(4)°,V= 406.67(5) Å3andZ= 2. The strongest reflections of the powder XRD pattern [d, Å (I, %) (hkl)] are: 9.17 (100) (001), 5.501 (57) (011), 3.437 (59) (020), 3.058 (43) (003), 2.918 (50) (2¯11), 2.795 (35) (013) and 2.753 (50) (121, 201). The crystal structure was solved based on single-crystal X-ray diffraction data,R1= 5.71%. The structure of antofagastaite consists of ordered and disordered blocks and is related to syngenite K2Ca(SO4)2·H2O. Incorporation of additional H2O molecules in the syngenite-type structure results in disorder of the one of the two tetrahedral sulfate groups occurring in antofagastaite. In addition to the above-reported type material, antofagastaite together with syngenite and blödite occurs in the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia.
Effect of swim bladder matrix treated with hyaluronic acid on wound healing: an animal model evaluation
Authors: Jalali Sajedeh , Fereidoni Masoud , Shahri Nasser Mahdavi , Lari Roya 
Published: April 2019

Objective: To investigate the potential restorative effects of the white fish (Rutilus frisii kutum) swim bladder matrix (FSBM) treated with hyaluronic acid (HA) in the repair of skin wounds in an animal model. Method: Wistar rats were used to investigate the repair function of FSBM as a biological scaffold. Rats were given four round wounds on their back. Wounds were divided into four groups: control, acellular fish swim bladder matrix (AFSBM), HA and AFSBM impregnated with HA (AFSBM-HA). Macroscopic and histological studies in wound healing were investigated on days three, five and seven after injury. Results: The AFSBM-HA group showed a rapid reduction in wound area compared with the other groups, indicating faster wound healing (p<0.001). At day seven after injury, the AFSBM group showed a faster process in epidermal layer formation and angiogenesis compared with the control group (p<0.001). In the AFSBM-HA group, in addition to the reduction of inflammatory cells density, a significant increase in the number of fibroblast cells and collagen synthesis was observed. An elevation in collagen synthesis and angiogenesis was also observed in the HA group compared with the control group. Conclusion: The findings of this study indicate that AFSBM-HA can potentially be used as a biological dressing in wound healing.
The European board of orthodontists: a challenge at any stage
Authors: Brierley Catherine , Hodge Trevor 
Published: April 2019

Recognizing differences in the standards of orthodontic postgraduate education across Europe, the European Board of Orthodontists was established in 1997 with the aim of providing a standard against which an orthodontist could be judged independent of national barriers and, in so doing, promoting high standards of care. This article describes the experiences of both authors who sat the assessment at the June 2018 diet held at the European Orthodontic Congress in Edinburgh. CPD/Clinical Relevance: Application for membership to the European Board of Orthodontists requires clinicians to work towards illustrating well-described and applied clinical procedures to correct significant orthodontic problems to an identified excellent standard. In the pursuit of attaining this recognition, orthodontists will invariably reflect on the treatments they provided and undoubtedly learn more, as well as seeing improvements in the standard of their patients' care.
Perempuan Dalam Kultur Patriarkhi Media (Book Review)
Authors: Mustofa Mustofa 
Published: April 2019

Judul Buku : Wanita clan Media MassaPenulis : Hj. Siti Sholihati, MA.Editor : Muammar RamadhanVolume : xii + 164 halaman.Penerbit : TERAS, Yogyakarta.Cetakan : Pertama, Mei 2007
Kesetaraan Gender: Panggilan Nurani Membebaskan "Manusia yang Dianggap Kelas Dua"
Authors: Tobroni Faiq 
Published: April 2019

Judul Buku : Kekerasan Terhadap Perempuan Tinjauan dalam Berbagai Disiplin Ilmu & Kasus KekerasanEditor : Dr. M. Munandar Sulaeman dan Ir. Siti Homzah, MS.Penerbit : PT Refika Aditama Kata BandungTahun terbit: Maret 2010Volume : 136 + X halaman.