bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted surgical parathyroidectomy in end‐stage renal disease patients and long‐term metabolic control: A single‐center experience in the current era
Authors: Fülöp Tibor , Koch Christian A. , Farah Musa Abdeen R. , Clark Christopher M. , Gharaibeh Kamel A. , Lengvársky Zsolt , Hamrahian Mehrdad , Pitman Karen T. , Dixit Mehul P. 
Published: February 2018

AbstractBackground: The long‐term results of surgical parathyroidectomy (PTX) in end‐stage renal disease (ESRD) patients are less well known in the modern era of newer activated vitamin‐D analogs, calcimimetics and intraoperative monitoring of parathyroid hormone (PTH).Methods: We performed a retrospective chart review of all ESRD patients undergoing PTX at the University of Mississippi Medical Center between January 2005 and August 2011, with follow‐up data as available up to 4 years. All PTXs were performed with intraoperative second‐generation PTH monitoring and targeted gland size reduction.Results: The cohort (N = 37) was relatively young with a mean (±SD) age of 48.4 ± 13.9. 94.6% of the subjects were African American and 59.5% female. Preoperatively, 45.9% received cinacalcet (CNC) at a mean dose of 63.5 ± 20.9 mg. The size of the largest removed glands measured 1.7 ± 0.8 cm and almost all (94.6%) glands had hyperplasia on histology. The mean length of inpatient stay was 5.5 ± 2.4 days. Preoperative calcium/phosphorus measured 9.6 ± 1.2/6.6 ± 1.7 mg/dL with PTH concentrations of 1589 ± 827 pg/mL. Postoperative PTH values measured 145.4 ± 119.2 pg/mL. Preoperative PTH strongly correlated (P < 0.0001) with both alkaline phosphatase (ALP) levels (r: 0.596) and the number of inpatient days (r: 0.545), but not with CNC administration. Independent predictors for the duration of hospitalization were preoperative ALP (beta 0.469; P = 0.001) and age (beta −0.401; P = 0.005) (R2 0.45); for postoperative hypocalcemia, age (beta: −0.321; P = 0.006) and preoperative PTH (beta: 0.431; P = 0.036) were significant in linear regression models with stepwise selection.Conclusion: Gland‐sparing PTX achieved acceptable control of ESRD‐associated hyperparathyroidism in most patients from a socioeconomically challenged, underserved population of the United States.
Uridine 5'diphospho‐glucuronosyltransferase 1A expression as an independent prognosticator in urothelial carcinoma of the upper urinary tract
Authors: Izumi Koji , Inoue Satoshi , Ide Hiroki , Fujita Kazutoshi , Mizushima Taichi , Jiang Guiyang , Yamaguchi Seiji , Fushimi Hiroaki , Nonomura Norio , Miyamoto Hiroshi 
Published: February 2018

ObjectiveTo determine the expression status of uridine 5'diphospho‐glucuronosyltransferase 1A, a major phase II drug metabolism enzyme, in upper urinary tract urothelial carcinoma, as well as to assess its prognostic significance.MethodsWe immunohistochemically stained for uridine 5'diphospho‐glucuronosyltransferase 1A in tissue microarray consisting of 99 upper urinary tract urothelial carcinoma samples and paired non‐neoplastic urothelial tissues. We also assessed the effect of uridine 5'diphospho‐glucuronosyltransferase 1A knockdown on urothelial cancer cell growth.ResultsUridine 5'diphospho‐glucuronosyltransferase 1A was positive in 92.9% (27.3% weak [1+], 37.4% moderate [2+], 28.3% strong [3+]) of tumors, which was significantly (P < 0.001) lower than in benign urothelial tissues (98.8%; 3.5% 1+, 18.8% 2+, 76.4% 3+). All 37 (100%) non‐muscle‐invasive versus 55 (88.7%) of 62 muscle‐invasive tumors (P = 0.043) were immunoreactive for uridine 5'diphospho‐glucuronosyltransferase 1A. The rates of moderate‐to‐strong uridine 5'diphospho‐glucuronosyltransferase 1A expression and its positivity were also strongly associated with the absence of concomitant carcinoma in situ (P = 0.034) and lymphovascular invasion (P = 0.016), respectively. However, there were no statistically significant associations between uridine 5'diphospho‐glucuronosyltransferase 1A expression and tumor grade or pN/M status. Uridine 5'diphospho‐glucuronosyltransferase 1A loss in M0 tumors was strongly associated with lower progression‐free survival (P < 0.001) and cancer‐specific survival (P < 0.001) rates. Multivariate analysis further identified a strong correlation of uridine 5'diphospho‐glucuronosyltransferase 1A positivity with reduced cancer‐specific mortality (hazard ratio 0.28, P = 0.018). Meanwhile, uridine 5'diphospho‐glucuronosyltransferase 1A knockdown in urothelial cancer cells resulted in significant increases in their viability and migration.ConclusionsThese results suggest a preventive role of uridine 5'diphospho‐glucuronosyltransferase 1A signals in the development and progression of upper urinary tract urothelial carcinoma. Loss of uridine 5'diphospho‐glucuronosyltransferase 1A expression might serve as an independent predictor of poor prognosis in patients with upper urinary tract urothelial carcinoma.
Annual estimates of the burden of seasonal influenza in the United States: A tool for strengthening influenza surveillance and preparedness
Authors: Rolfes Melissa A. , Foppa Ivo M. , Garg Shikha , Flannery Brendan , Brammer Lynnette , Singleton James A. , Burns Erin , Jernigan Daniel , Olsen Sonja J. , Bresee Joseph , Reed Carrie 
Published: February 2018

BackgroundEstimates of influenza disease burden are broadly useful for public health, helping national and local authorities monitor epidemiologic trends, plan and allocate resources, and promote influenza vaccination. Historically, estimates of the burden of seasonal influenza in the United States, focused mainly on influenza‐related mortality and hospitalization, were generated every few years. Since the 2010‐2011 influenza season, annual US influenza burden estimates have been generated and expanded to include estimates of influenza‐related outpatient medical visits and symptomatic illness in the community.MethodsWe used routinely collected surveillance data, outbreak field investigations, and proportions of people seeking health care from survey results to estimate the number of illnesses, medical visits, hospitalizations, and deaths due to influenza during six influenza seasons (2010‐2011 through 2015‐2016).ResultsWe estimate that the number of influenza‐related illnesses that have occurred during influenza season has ranged from 9.2 million to 35.6 million, including 140 000 to 710 000 influenza‐related hospitalizations.DiscussionThese annual efforts have strengthened public health communications products and supported timely assessment of the impact of vaccination through estimates of illness and hospitalizations averted. Additionally, annual estimates of influenza burden have highlighted areas where disease surveillance needs improvement to better support public health decision making for seasonal influenza epidemics as well as future pandemics.
Anne Finch in the twenty‐first century: Finding the artist in history
Authors: Keith Jennifer 
Published: February 2018

AbstractMuch twenty‐first century scholarship on the work of Anne Finch shows that scholars increasingly see her artistry, proto‐feminism, and Jacobitism as creating a complex whole. Attending to the interrelations of these topics in Finch's work, scholars have found still more evidence for, and complications of, their claims by analyzing the archival record, particularly as it reveals her canny participation in manuscript and print publishing. Finch scholars find that her work fosters enquiries that also extend beyond her oeuvre, including revision of the contours of literary history and value as well as reassessment of women writers' level of engagement in their contemporary literary and sociopolitical contexts. That this much has been achieved in Finch studies without a scholarly edition of her work is remarkable, but many gaps persist because scholars have lacked access to critically established texts that have been placed in their archival and cultural contexts. Such gaps are widened by the fact that many of her works are still understudied, with some entirely ignored. This attention to a small portion of Finch's oeuvre cannot provide an accurate view of the extent of her literary innovations; the nuances of her political and social views; or even an outline of the literary, social, and political relations that guided her uses of manuscript and print publishing. The close of the essay proposes future directions for Finch studies when scholars will have in hand The Cambridge edition of the works of Anne Finch, Countess of Winchilsea.
Uncontrolled blood pressure affects atrial remodeling and adverse clinical outcome in paroxysmal atrial fibrillation
Authors: Kamioka Masashi , Hijioka Naoko , Matsumoto Yoshiyuki , Nodera Minoru , Kaneshiro Takashi , Suzuki Hitoshi , Takeishi Yasuchika 
Published: February 2018

AbstractBackgroundTo investigate the impact of uncontrolled blood pressure (BP) on left atrial (LA) remodeling and clinical outcome after pulmonary vein isolation (PVI) in paroxysmal atrial fibrillation (AF).MethodsOne hundred and one symptomatic paroxysmal AF patients (85 males, 62.2 ± 8.4‐year‐old) who underwent successful PVI were classified as follows: group 1 (n = 46), no hypertension (HTN); group 2 (n = 36), HTN with controlled BP; and group 3 (n = 19), HTN with uncontrolled BP. Uncontrolled BP was defined as BP > 140/90 mm Hg. LA dimension was measured by echocardiography before and 6 months after PVI. LA wall thickness along the ablation line was measured using computed tomography prior to PVI. Cox regression analysis was performed for the prediction of recurrence.ResultsLA wall thickness in groups 2 and 3 was greater than that of group 1, except for the anterior right superior pulmonary vein (PV) and posterior left inferior PV. Kaplan‐Meier analysis revealed a significantly higher recurrence in group 3 (52.6%). LA dimension only increased in group 3 (38.2 ± 5.6 mm to 41.3 ± 6.2 mm, P = 0.022). At the second procedure, all group 3 recurrent patients showed substrate degradation (low voltage area and/or dense scar formation) and required substrate modification. Uncontrolled BP was an independent risk factor for recurrence (hazard ratio: 2.350, P = 0.033).ConclusionsHTN induced heterogeneous LA hypertrophy regardless of whether HTN was controlled. Uncontrolled BP promoted atrial remodeling, and is therefore a strong predictor for recurrence of AF after PVI.
Orobanche cernua Loefling Attenuates Ultraviolet B‐mediated Photoaging in Human Dermal Fibroblasts
Authors: Gao Wei , Wang Yu‐shuai , Qu Zheng‐yi , Hwang Eunson , Ngo Hien T. T. , Wang Ying‐ping , Bae Jahyun , Yi Tae‐hoo 
Published: February 2018

AbstractUV radiation is the primary cause of skin photoaging, which results in an increase in matrix metalloproteinases and degradation of collagen. Developing new natural antioxidant as photoprotective agents has become a popular area of research. Orobanche cernua Loefling is a parasitic plant that is rich in phenylethanoid glycosides (PhGs). This study investigated the photoprotective effects of the ethanolic extract of Orobanche cernua Loefling (OC) and its principal component acteoside on UVB‐induced photoaging as well as their underlying molecular mechanisms in normal human dermal fibroblasts (NHDFs). Biological testing demonstrated that OC and acteoside possessed significant photoprotective activities, reducing MMP and IL‐6 levels while improving type‐I procollagen synthesis in UVB‐irradiated NHDFs. Further study showed that the protective mechanisms were the improvement of transcription factor Nrf2‐mediated antioxidant defensive system, suppression of MAPK/AP‐1 and activation of the TGF‐β/Smad pathway. Together, our results suggested that OC might be a promising antiphotoaging agent against UV radiation‐induced skin damage.
A Semiempirical Approach to the Determination of Daily Erythemal Doses
Authors: Silva Abel A. , Yamamoto Ana L. C. , Corrêa Marcelo P. 
Published: February 2018

AbstractThe maintenance of ground‐based instruments to measure the incidence of ultraviolet radiation (UVR) from the Sun demands strict and well‐developed procedures. A piece of equipment can be out of service for a couple of weeks or months for calibration, repair or even the improvement of the facilities where it has been set up. However, the replacement of an instrument in such circumstances can be logistically and financially prohibitive. On the other hand, the lack of data can jeopardize a long‐term experiment. In this study, we introduce a semiempirical approach to the determination of the theoretical daily erythemal dose (DEDt) for periods of instrumental absence in a tropical site. The approach is based on 5 years of ground‐based measurements of daily erythemal dose (DED) linearly correlated with parameters of total ozone column (TOC) and reflectivity (RPC) from the Ozone Monitoring Instrument (OMI) and the cosine of solar zenith angle at noon (SZAn). Seventeen months of missing ground‐based data were replaced with DEDt, leading to a complete 5‐year series of data. The lowest and the highest values of typical DED were 2411 ± 322 J m−2 (1σ) (winter) and 5263 ± 997 J m−2 (summer). The monthly integrated erythemal dose (mED) varied from 59 kJ m−2 (winter) to 162 kJ m−2 (summer). Both of them depended mainly on cos(SZAn) and RPC. The 12‐month integrated erythemal dose (12‐ED) ranged from 1350 kJ m−2 to 1546 kJ m−2, but it can depend significantly on other atmospheric parameter (maybe aerosols) not explicitly considered here.
The Effect of Pyrazolyl Substituents on the Photophysical and Photochemical Properties of Pyrazine Derivatives
Authors: Pizarro Nancy , Prado Gaspar , Saldías Marianela , Sandoval‐Altamirano Catalina , Vega Andrés 
Published: February 2018

AbstractThe reaction of 2,5‐dibromopyrazine with N‐Lithium pyrazolate in a 1:2 ratio leads to a mixture of 2‐bromo‐5‐(1H‐pyrazol‐1‐yl)pyrazine (I) and 2,5‐di(1H‐pyrazol‐1‐yl)pyrazine (II). The structures of I and II are highly planar. Two absorption bands can be observed for the compounds in the UV‐Vis region, having ε in the order of 104 m−1 cm−1. TD‐DFT computed results support the nature of the lower energy absorptions as πpyrazine→π*pyrazine transitions, including an additional intraligand charge transfer transition for I (πpyrazol→π*pyrazine). Upon excitation at 280 or 320 nm, the emission of both compounds is almost not affected by solvent polarity or oxygen presence, showing two bands for I and one for II in the 350–450 nm region. Emission of II follows a mono‐exponential decay, while I decays following a bi‐exponential law, hypothesized from πpyrazine→π*pyrazine and πpyrazol→π*pyrazine transitions. Photodegradation of I and II follows a first‐order kinetic with constants of 1.18 × 10−2 min−1 and 0.13 × 10−2 min−1, respectively. Results suggest that photodegradation of I starts with the loose of bromide followed by intermolecular pyrazolyl subtraction and ring opening. This path is not available for II, which is reflected in its enhanced photostability.
Potential for Porphyry Copper Mineralization Below the Kasuga Lithocap, Nansatsu District, Japan
Authors: Izawa Eiji , Hayashi Toshihiko 
Published: February 2018

AbstractLithocaps consist of vuggy residual quartz and advanced argillic alteration formed at shallow depths and potentially related to porphyry copper‐bearing intrusions at depth, meaning that, conceptually, porphyry copper deposits may exist beneath the lithocap‐hosted Nansatsu‐type gold deposits. The Kasuga lithocap extends for about 5 km NE–SW by 2 km width; beyond the northeastern edge of this lithocap, there are contemporaneous epithermal gold‐quartz veins. A 1200‐m hole was drilled in 1999 beneath the main orebody at Kasuga but did not intersect porphyry copper mineralization. On the basis of detailed examination of the alteration pattern and paleothermal environment of the Kasuga area, a paleo high‐temperature zone appears to lie in a NE‐ward direction from the deep drilling site.
Extracorporeal photopheresis as second‐line therapy for patients with acute graft‐versus‐host disease: does the number of cells treated matter?
Authors: Worel Nina , Lehner Elisabeth , Führer Harald , Kalhs Peter , Rabitsch Werner , Mitterbauer Margit , Hopfinger Georg , Greinix Hildegard T. 
Published: February 2018

BACKGROUNDExtracorporeal photopheresis (ECP) has demonstrated efficacy as second‐line treatment for steroid‐refractory (SR) acute graft‐versus‐host disease (aGVHD). The aim of our study was to analyze whether the amount of ECP‐treated cells in patients with SR, aGVHD has an impact on response at 1 month.STUDY DESIGN AND METHODSData on white blood cells, lymphocytes, monocytes, mononuclear cells, and neutrophils, including absolute counts and counts per kilogram of body weight in ECP products from patients with aGVHD, were collected. For each cell population, the median dose per single ECP and the cumulative doses collected during the first week and the first month of treatment were compared with the response to ECP.RESULTSIn total, 99 patients underwent 1215 ECP procedures. Overall response was defined as a complete response if all signs of aGVHD resolved or a partial response if greater than 50% resolution was reached without other, additional immunosuppression. An overall response was obtained by 75% of patients, including 53% complete responses. Univariate analysis showed a correlation of lymphocytes and mononuclear cells/kg body weight for a single procedure and overall response. In logistic regression analysis, no tested variable had an influence on response. In receiver operating characteristic curve analysis, cutoffs of 8.4 × 106/kg body weight lymphocytes and 13.9 × 106/kg body weight mononuclear cells were associated with an overall response to ECP at 1 month with 75% sensitivity.CONCLUSIONOur results in patients with steroid‐refractory aGVHD confirm that response rates to ECP are high and that certain cutoff values for lymphocytes and mononuclear cells/kg body weight in each individual procedure can predict an overall response to ECP at 1 month.
A method for red blood cell biotinylation in a closed system
Authors: de Back Djuna Z. , Vlaar Richard , Beuger Boukje , Daal Brunette , Lagerberg Johan , Vlaar Alexander P.J. , de Korte Dirk , van Kraaij Marian , van Bruggen Robin 
Published: February 2018

BACKGROUNDSeveral circumstances require the accurate measurement of red blood cell (RBC) survival and clearance, such as determination of posttransfusion recovery of stored RBCs to investigate the effect of new additive solutions. To this end, biotin as a marker of RBCs to track donor RBCs in the blood of the recipient has been used in many studies. However, so far only experimental, nonvalidated, biotin‐labeled red cell concentrates (RCCs) are transfused. The goal of this study was to produce a standardized biotin‐labeled RCC product in a fast, simple, and sterile manner that can be used for clinical research and for the evaluation of new blood products according to Good Practice Guidelines (GPG) for blood establishments.STUDY DESIGN AND METHODSRCC fractions were labeled with two different concentrations of biotinylation reagent in a closed system, to prevent bacterial contamination of the end product. Using flow cytometry, the reproducibility and robustness of the biotin labeling was assessed, as well as the stability of the biotin label on the (un‐)irradiated RCC fraction. Additionally, parameters such as phosphatidylserine (PS) exposure, sodium (Na), potassium (K), free hemoglobin, adenosine triphosphate (ATP), pH, and morphology were determined prior to and after biotin labeling to rule out detrimental effects of the labeling procedure on the RCC.RESULTSOur data show that RCCs can be labeled under sterile conditions in a closed system with two different biotinylation reagent concentrations, without affecting the biological activity.CONCLUSIONAn easy, rapid (<2 hr), and robust method was developed to manufacture biotin‐labeled RCCs for clinical research compliant to GPG.
Reflections on the Maturing Research Literature of Self-Talk in Sport: Contextualizing the Special Issue
Authors: Hardy James , Comoutos Nikos , Hatzigeorgiadis Antonis 
Published: February 2018

Over the last 20 years research investigating self-talk in the context of sport has expanded rapidly enhancing our understanding of the construct. In the present article, we provide a brief historical review of the sports-oriented self-talk literature. In so doing we identify landmark investigations and review conceptual, research, and measurement themes present within the literature. We review this empirically based literature, distinguishing between three time periods: (1) the early foundations of self-talk research, up to the end of the 1990s; (2) the developmental years of systematic self-talk research during the 2000s; and (3) the modern day maturation of self-talk research, post-2011.
Winter color polymorphisms identify global hot spots for evolutionary rescue from climate change
Authors: Mills L. Scott , Bragina Eugenia V. , Kumar Alexander V. , Zimova Marketa , Lafferty Diana J. R. , Feltner Jennifer , Davis Brandon M. , Hackländer Klaus , Alves Paulo C. , Good Jeffrey M. , Melo-Ferreira José , Dietz Andreas , Abramov Alexei V. , Lopatina Natalia , Fay Kairsten 
Published: February 2018

Changing coats with the seasonMany species of mammals and birds molt from summer brown to winter white coats to facilitate camouflage. Millset al.mapped global patterns of seasonal coat color change across eight species including hares, weasels, and foxes. They found regions where individuals molt to white, brown, and both white and brown winter coats. Greater proportions of the populations molted to white in higher latitudes. Regions where seasonal coat changes are the most variable (molting to both brown and white) may provide resilience against the warming climate.Science, this issue p.1033
Rewritable multi-event analog recording in bacterial and mammalian cells
Authors: Tang Weixin , Liu David R. 
Published: February 2018

Writing a cell's history in its DNA
Recording cellular events could advance our understanding of cellular history and responses to stimuli. The construction of intracellular memory devices, however, is challenging. Tang and Liu used Cas9 nucleases and base editors to record amplitude, duration, and order of stimuli as stable changes in both genomic and extrachromosomal DNA content (see the Perspective by Ho and Bennett). The recording of multiple stimuli—including exposure to antibiotics, nutrients, viruses, and light, as well as Wnt signaling—was achieved in living bacterial and human cells. Recorded memories could be erased and re-recorded over multiple cycles.

Science
, this issue p.
eaap8992
; see also p.
150
Promoter Variation and Gene Expression of
mcr-1
-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital
Authors: Huang Bin , He Yuting , Ma Xingyan , Cai Renxin , Zeng Jianming , Lu Yang , Zhang Weizheng , Lan Kai , E Sunmei , Tang Yi-Wei , Kreiswirth Barry N. , Chen Cha , Chen Liang 
Published: February 2018

ABSTRACT

Next-generation sequencing of 6
mcr-1
-harboring
Escherichia coli
and
Klebsiella pneumoniae
isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking the
mcr-1
gene. While sequence variations significantly affected the expression and promoter activity of
mcr-1
, the
mcr-1
gene expression levels did not correlate with the
in vitro
colistin resistance levels, which warrants further in-depth investigations.
PGI2 Is a Novel SGI1-Relative Multidrug-Resistant Genomic Island Characterized in Proteus mirabilis
Authors: Lei Chang-Wei , Chen Yan-Peng , Kong Ling-Han , Zeng Jin-Xin , Wang Yong-Xiang , Zhang An-Yun , Wang Hong-Ning 
Published: February 2018

ABSTRACT

A novel 61,578-bp genomic island named
Proteus
genomic island 2 (PGI2) was characterized in
Proteus mirabilis
of swine origin in China. The 23.85-kb backbone of PGI2 is related to those of
Salmonella
genomic island 1 and
Acinetobacter
genomic island 1. The multidrug resistance (MDR) region of PGI2 is a complex class 1 integron containing 14 different resistance genes. PGI2 was conjugally mobilized in
trans
to
Escherichia coli
in the presence of a conjugative IncC helper plasmid.