bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diarrhoea, enteric pathogen detection and nutritional indicators among controls in the Global Enteric Multicenter Study, Kenya site: an opportunity to understand reference populations in case–control studies of diarrhoea
Authors: Berendes D. M. , O'Reilly C. E. , Kim S. , Omore R. , Ochieng J. B. , Ayers T. , Fagerli K. , Farag T. H. , Nasrin D. , Panchalingam S. , Nataro J. P. , Kotloff K. L. , Levine M. M. , Oundo J. , Laserson K. , Breiman R. F. , Mintz E. D. 
Published: November 2018

AbstractGiven the challenges in accurately identifying unexposed controls in case–control studies of diarrhoea, we examined diarrhoea incidence, subclinical enteric infections and growth stunting within a reference population in the Global Enteric Multicenter Study, Kenya site. Within ‘control’ children (0–59 months old without diarrhoea in the 7 days before enrolment,n= 2384), we examined surveys at enrolment and 60-day follow-up, stool at enrolment and a 14-day post-enrolment memory aid for diarrhoea incidence. At enrolment, 19% of controls had ⩾1 enteric pathogen associated with moderate-to-severe diarrhoea (‘MSD pathogens’) in stool; following enrolment, many reported diarrhoea (27% in 7 days, 39% in 14 days). Controls with and without reported diarrhoea had similar carriage of MSD pathogens at enrolment; however, controls reporting diarrhoea were more likely to report visiting a health facility for diarrhoea (27%vs.7%) or fever (23%vs.16%) at follow-up than controls without diarrhoea. Odds of stunting differed by both MSD and ‘any’ (including non-MSD pathogens) enteric pathogen carriage, but not diarrhoea, suggesting control classification may warrant modification when assessing long-term outcomes. High diarrhoea incidence following enrolment and prevalent carriage of enteric pathogens have implications for sequelae associated with subclinical enteric infections and for design and interpretation of case–control studies examining diarrhoea.
Management of Painful Physical Symptoms Associated With Depression and Mood Disorders
Authors: Wise Thomas N. , Arnold Lesley M. , Maletic Vladimir , Ginsberg David L. 
Published: November 2018

AbstractDepression is a common, recurring illness that continues to be underdiagnosed and undertreated in both psychiatric and primary care settings. It is increasingly being recognized that painful physical symptoms, which commonly exist comorbid with depressive disorders, play a role in complicating diagnosis of depression. Patients tend to discuss physical pain with primary care physicians and emotional pain with psychiatrists, often oblivious to the fact that both may be aspects of one disorder. Those who present with somatic complaints are three times less likely to be accurately diagnosed than patients with psychosocial complaints. However, thorough evaluation of mood and anxiety disorders in primary care is sparse due to the limited time primary care physicians can spend with each patient. Better recognition and treatment of both physical and emotional symptoms associated with mood disorders may increase a patient's chance of achieving remission, which is the optimum therapeutic goal.Abnormalities of serotonin and noradrenaline are strongly associated with depression and are thought to play a role in pain perception. Brain-derived neurotrophic factor, which is increased with antidepressant treatment, appears to influence regulation of mood and perception of pain. Clinical evidence indicates that dual-acting agents may have an advantage in modulating pain over those agents that increase either serotonin or noradrenaline alone. The novel dual-acting agents, such as venlafaxine and duloxetine, are better tolerated than tricyclic antidepressants and monoamine oxidase inhibitors. These agents have demonstrated efficacy in depression and in diabetic neuropathic pain independently. Therefore, unless otherwise stated, all inferences to studies of pain in this monograph refer to neuropathic pain in nondepressed patients.
Time and Temperature Dependent Creep in Tournemire Shale
Authors: Geng Zhi , Bonnelye Audrey , Chen Mian , Jin Yan , Dick Pierre , David Christian , Fang Xin , Schubnel Alexandre 
Published: November 2018

AbstractWe conducted a series of triaxial creep experiments on shale specimens coming from Tournemire, France, using the stress‐stepping method up to failure, at a confining pressure of 80 MPa, on two orientations (parallel and perpendicular to bedding), and at temperatures of 26 and 75 °C. In these week‐long experiments, stress, strains, and P wave ultrasonic velocities were recorded (quasi‐) continuously. The strength at creep failure of Tournemire shale was ~70% higher than the peak strength measured during constant strain rate (~10−7/s) experiments, and failure was reached at larger strains. An overall transition from P wave velocity increase at moderate differential stress to P wave velocity decrease closer to brittle failure was also observed. At a smaller timescale, P wave velocities initially decreased and then increased gradually during each step of creep deformation. The magnitude of these variations showed important (i) stress, (ii) orientation, and (iii) temperature dependences: larger increase was observed for P wave propagating along the main compressive stress orientation, larger decrease for P wave propagating perpendicular to it, and a changing behavior enhanced at a higher temperature. Scanning electron microscopy performed postmortem revealed evidence of time‐dependent pressure solution, localized compaction, crack growth, and sealing/healing. Our data reveal that shale deformation is highly stress sensitive only in a narrow stress domain where stress corrosion cracking‐induced brittle dilatant creep deformation is dominant. At stresses below, pressure solution compaction creep dominates the deformation and shales compact, consolidate, and heal. This has important implications for the mechanics of shallow fault zones and accretionary prisms.
Impact of the Surface Stress on the Volume and Freshwater Transport Through the Canadian Arctic Archipelago From a High‐Resolution Numerical Simulation
Authors: Grivault Nathan , Hu Xianmin , Myers Paul G. 
Published: November 2018

AbstractWe use a numerical model forced with high temporal and spatial resolution atmospheric forcing to evaluate the volume and freshwater transport through the Canadian Arctic Archipelago (CAA). On average, the simulated inflow through the Queen Elizabeth Islands represents 40% of the transport entering the CAA through M'Clure Strait. The transport through Admunsden Gulf represents less than 10% of the total inflow. The impact of sea ice and winds on the volume and freshwater transports into and through this region is also investigated. At Nares Strait and West Lancaster Sound, the transport is overestimated due to too‐mobile sea ice but different physical processes related to surface stress. The ice is driving larger ocean flow in the first case, while causing less flow reduction in the second case. While the transport through the Queen Elizabeth Islands responds to the changes in surface stress over the Beaufort Gyre and northern Baffin Bay, local surface stress opposed to the mean flow over the straits tends to reduce the throughflow transport. In Parry Channel and the southern CAA, the surface stress tends to enhance the transport and have a greater impact locally. Finally, the surface stress related to sea ice motion can significantly change the transport in the CAA during the winter months.
Revised diagnostic criteria for plasma cell leukemia: results of a Mayo Clinic study with comparison of outcomes to multiple myeloma
Authors: Ravi Praful , Kumar Shaji K. , Roeker Lindsey , Gonsalves Wilson , Buadi Francis , Lacy Martha Q. , Go Ronald S. , Dispenzieri Angela , Kapoor Prashant , Lust John A. , Dingli David , Lin Yi , Russell Stephen J. , Leung Nelson , Gertz Morie A. , Kyle Robert A. , Bergsagel P. Leif , Rajkumar S. Vincent 
Published: November 2018

AbstractThe current definition of plasma cell leukemia (PCL)— ≥ 20% circulating plasma cells (CPCs) on peripheral smear and plasma cell count ≥ 2 × 109/L—may be too stringent. We reviewed outcomes of 176 multiple myeloma (MM) patients diagnosed between 1971 and 2016, and who had CPCs detectable at diagnosis, to determine whether a lower threshold could be used to diagnose PCL. Median overall survival (mOS) was 1.1 years (95% CI 0.8–1.4) and was similar between patients with < 5% (n = 54, mOS = 1.4 years [0.7–2.0]), 5–19% (n = 63, mOS = 1.1 years [0.7–1.4]), and ≥ 20% CPCs (n = 59, mOS = 1.1 years [0.7–1.5], p = 0.349). As survival was similar between those with 5–19% and ≥ 20% CPCs, we stratified patients by < 5% (mOS = 1.4 years [0.7–2.0]) and ≥ 5% CPCs (mOS = 1.1 years [0.8–1.4], p = 0.154). Outcomes of those with ≥ 5% CPCs were much poorer when compared with a cohort of MM patients diagnosed between 1971 and 2016, who did not have CPCs at diagnosis (n = 9724, mOS = 4.4 yrs [4.3–4.5], p < 0.001); survival was also lower in patients diagnosed after 2001 with ≥ 5% CPCs (n = 62, mOS = 1.4 years [0.8–2.5]) compared with patients with standard risk (n = 1326, mOS = 7.5 years [7.0–8.7]) and high-risk MM (n = 381, mOS = 4.3 years [3.5–4.9], p < 0.001). We therefore propose that the definition of PCL be revised to patients with ≥ 5% CPCs on peripheral blood smear, who otherwise meet diagnostic criteria for MM.
A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating
Authors: Ni Yan-Xiang , Zhou Nan , Xue Wen-Qian , Rong Li , Yung Wing-Ho , Lin Rao-Zhou , Kao Richard Yi-Tsun , Duan Zhi-Gang , Sun Hai-Tao , Gong Hua-Rui , Tang Xu-Ming , Liu Meng-Fei , Zhang Wen , Qi Shuang , Chung Sookja , Song You-Qiang , Huang Jian-Dong 
Published: November 2018

AbstractKif5b-driven anterograde transport and clathrin-mediated endocytosis (CME) are responsible for opposite intracellular trafficking, contributing to plasma membrane homeostasis. However, whether and how the two trafficking processes coordinate remain unclear. Here, we show that Kif5b directly interacts with clathrin heavy chain (CHC) at a region close to that for uncoating catalyst (Hsc70) and preferentially localizes on relatively large clathrin-coated vesicles (CCVs). Uncoating in vitro is decreased for CCVs from the cortex of kif5b conditional knockout (mutant) mouse and facilitated by adding Kif5b fragments containing CHC-binding site, while cell peripheral distribution of CHC or Hsc70 keeps unaffected by Kif5b depletion. Furthermore, cellular entry of vesicular stomatitis virus that internalizes into large CCV is inhibited by Kif5b depletion or introducing a dominant-negative Kif5b fragment. These findings showed a new role of Kif5b in regulating large CCV-mediated CME via affecting CCV uncoating, indicating Kif5b as a molecular knot connecting anterograde transport to CME.
Deep Feature Learning for Sudden Cardiac Arrest Detection in Automated External Defibrillators
Authors: Nguyen Minh Tuan , Nguyen Binh Van , Kim Kiseon 
Published: November 2018

AbstractVentricular fibrillation and ventricular tachycardia (VF/VT), known as shockable (SH) rhythms, are the mainly cause of sudden cardiac arrests (SCA), which is cured efficiently by the automated external defibrillator (AED). The performance of the shock advice algorithm (SAA) applied in the AED has been improved by using machine learning technique and variously conventional features, recently. In this paper, we propose a novel algorithm with relatively high performance for the SCA detection on electrocardiogram (ECG) signal. The algorithm consists of a convolutional neural network as a feature extractor (CNNE) and a Boosting (BS) classifier. A grid search with nested 5-folds cross validation (CV) is used to select the CNNE trained with preprocessed ECG, SH, and NSH signals using the modified variational mode decomposition technique. The deep feature vector learned by this CNNE is extracted at the first fully connected layer and then fed into BS classifier to validate its performance using 5-folds CV procedure. The secondary learning of the BS classifier and the use of three input channels for the CNNE improve certainly the detection performance of the proposed SAA with the validated accuracy of 99.26%, sensitivity of 97.07%, and specificity of 99.44%.
Grazers extend blue carbon transfer by slowing sinking speeds of kelp detritus
Authors: Wernberg Thomas , Filbee-Dexter Karen 
Published: November 2018

AbstractMarine plant communities such as kelp forests produce significant amounts of detritus, most of which is exported to areas where it can constitute an important trophic subsidy or potentially be sequestered in marine sediments. Knowing the vertical transport speed of detrital particles is critical to understanding the potential magnitude and spatial extent of these linkages. We measured sinking speeds for Laminaria hyperborea detritus ranging from whole plants to small fragments and sea urchin faecal pellets, capturing the entire range of particulate organic matter produced by kelp forests. Under typical current conditions, we determined that this organic material can be transported 10 s of m to 10 s of km. We show how the conversion of kelp fragments to sea urchin faeces, one of the most pervasive processes in kelp forests globally, increases the dispersal potential of detritus by 1 to 2 orders of magnitude. Kelp detritus sinking speeds were also faster than equivalent phytoplankton, highlighting its potential for rapid delivery of carbon to deep areas. Our findings support arguments for a significant contribution from kelp forests to subsidizing deep sea communities and the global carbon sink.
Design and modeling of pulsed-laser three-dimensional imaging system inspired by compound and human hybrid eye
Authors: Cheng Yang , Cao Jie , Zhang Fanghua , Hao Qun 
Published: November 2018

AbstractA pulsed-laser three-dimensional imaging system inspired by compound and human hybrid eye is proposed. A diffractive optical element is used to enlarge field of view (FOV) of transmitting system and a receiving system consisting of a non-uniform microlens array, an aperture array, and an avalanche photodiode array is designed. The non-uniform microlens array is arranged on a curved surface to mimic large FOV feature of the compound eye. Meanwhile, the non-uniform microlens array is modeled to mimic space-variant resolution property of the human eye. On the basis of the proposed system, some simulation experiments are carried out. Results show that the entire FOV is up to 52°, and the resolution is 30 × 18. The proposed system has a high resolution in the center FOV and a low resolution in the peripheral FOV. The rotation and scaling invariances of the human eye are verified on the proposed system. The signal-to-noise ratio (SNR) increases with the increase in the number of rings and the maximum SNR locates at the outmost periphery area. This work is beneficial to the design of the pulsed laser three-dimensional imaging system with large FOV, high speed, and high resolution.
Exposure history, post-exposure prophylaxis use, and clinical characteristics of human rabies cases in China, 2006–2012
Authors: Guo Chun , Li Yu , Huai Yang , Rao Carol Y. , Lai Shengjie , Mu Di , Yin Wenwu , Yu Hongjie , Nie Shaofa 
Published: November 2018

AbstractRabies is still a public health threat in China. Evaluating the exposure history, clinical characteristics, and post-exposure prophylaxis (PEP) of the cases could help in identifying approaches to reducing the number of these preventable deaths. We analysed data collected from 10,971 case-investigations conducted in China from 2006 to 2012. Most cases (n = 7,947; 92.0%) were caused by animal bites; 5,800 (55.8%) and 2,974 (28.6%) exposures were from domestic and free-roaming dogs, respectively. Only 278 (4.8%) of these domestic dogs had previously received rabies vaccination. Among all cases, 5,927 (59.7%) cases had category III wounds, 1,187 (11.7%) cases initiated the rabies PEP vaccination and 234 (3.9%) cases with category III wounds received rabies immunoglobulin. In our adjusted logistic regression model, male cases (adjusted odds ratio [aOR] = 1.25, 95% confidence interval [CI]: 1.09–1.44) and farmers (aOR = 1.39, 95% CI: 1.10–1.77) and person older than 55 years (aOR = 1.48, 95% CI: 1.01–2.17) were less likely than females and persons in other occupations or younger than 15 years to initiate PEP vaccination. The median incubation period was 66 days (interquartile range (IQR): 33–167 days). To reduce the number of human deaths due to rabies, rabies prevention campaigns targeting males and farmers and older people should be conducted. Increasing routine rabies vaccination among domestic dogs will be essential in the long term.
The expansion of later Acheulean hominins into the Arabian Peninsula
Authors: Scerri Eleanor M. L. , Shipton Ceri , Clark-Balzan Laine , Frouin Marine , Schwenninger Jean-Luc , Groucutt Huw S. , Breeze Paul S. , Parton Ash , Blinkhorn James , Drake Nick A. , Jennings Richard , Cuthbertson Patrick , Omari Abdulaziz Al , Alsharekh Abdullah M. , Petraglia Michael D. 
Published: November 2018

AbstractThe Acheulean is the longest lasting cultural–technological tradition in human evolutionary history. However, considerable gaps remain in understanding the chronology and geographical distribution of Acheulean hominins. We present the first chronometrically dated Acheulean site from the Arabian Peninsula, a vast and poorly known region that forms more than half of Southwest Asia. Results show that Acheulean hominin occupation expanded along hydrological networks into the heart of Arabia from Marine Isotope Stage (MIS) 7 until at least ~190 ka ̶ the youngest documented Acheulean in Southwest Asia. The site of Saffaqah features Acheulean technology, characterized by large flakes, handaxes and cleavers, similar to Acheulean assemblages in Africa. These findings reveal a climatically-mediated later Acheulean expansion into a poorly known region, amplifying the documented diversity of Middle Pleistocene hominin behaviour across the Old World and elaborating the terminal archaic landscape encountered by our species as they dispersed out of Africa.
Hyperlipidemia, statin use and dengue severity
Authors: Chia Po Ying , Htun Htet Lin , Ling Wei Ping , Leo Yee Sin , Yeo Tsin Wen , Lye David Chien Boon 
Published: November 2018

AbstractMultiple in vitro and mice model studies suggest statins may attenuate dengue severity. However, little is known about statin use and dengue severity in adult dengue patients with hyperlipidemia. We conducted a retrospective cohort study from 2004–2008 and 2012–2013 in Tan Tock Seng Hospital, Singapore on adult dengue patients with hyperlipidemia, comparing those with and without statin usage at hospitalization in terms of primary outcome of dengue hemorrhagic fever (DHF) or shock syndrome (DSS), and severe dengue (SD). Of 13,975 subjects screened, 257 dengue patients were included; 191 (74.3%) were statin users and 66 (25.7%) were non-users. Compared with non-users, statin use was not associated with decreased risk of DHF/DSS (adjusted risk ratio [aRR] = 0.66, 95%confidence interval [CI]: 0.41–1.08, P = 0.10) and SD (aRR = 1.43, 95%CI: 0.84–2.43, P = 0.19). Therefore, statin usage had minimal effect on dengue severity in our study population in Singapore.
Isolation and characterization of 21 polymorphic microsatellite loci for the rockpool shrimp Palaemon elegans using Illumina MiSeq sequencing
Authors: González-Castellano Inés , Perina Alejandra , González-Tizón Ana M. , Torrecilla Zeltia , Martínez-Lage Andrés 
Published: November 2018

AbstractThe rockpool shrimpPalaemon elegansis considered an important crustacean species within the European coastline fauna. This species is experiencing an ongoing geographical expansion beyond its native distribution range due to unintentional human introductions. A better knowledge of the genetic diversity, geographic structure and connectivity of its populations is necessary. In the present study, microsatellite loci were isolated using the Illumina MiSeq platform. The microsatellite-enriched library sequencing produced 3.9 million raw reads. Reads were processed and primer pairs were designed for microsatellite sequences amplification. Ninety-six microsatellite loci were preliminary screened in individuals from Atlantic and Mediterranean localities. From them, 21 loci exhibited reliable polymorphism and were thoroughly characterized in 30 individuals from a Cantabrian locality (Spain). No linkage disequilibrium between pairs of loci was detected. Number of alleles per locus ranged from 2 to 12. Observed and expected heterozygosities ranged from 0.033 to 0.833 and from 0.033 to 0.869 respectively. No significant departure from the Hardy-Weinberg equilibrium was detected in most of loci. This is the first time that microsatellite markers have been developed forP.elegans. This characterized microsatellite suite provides new suitable tools for further analyses, facilitating the understanding of population genetics both in natural and introduced populations.
COMP and TSP-4 interact specifically with the novel GXKGHR motif only found in fibrillar collagens
Authors: Gebauer Jan M. , Köhler Anna , Dietmar Helen , Gompert Monika , Neundorf Ines , Zaucke Frank , Koch Manuel , Baumann Ulrich 
Published: November 2018

AbstractCOMP (cartilage oligomeric matrix protein) is a member of the thrombospondin family and forms homopentamers as well as mixed heterooligomers with its closely related family member TSP-4. COMP is long known to bind to collagens and to influence collagen fibril formation. Recent work indicates that already intracellular interaction with collagen is important for collagen secretion. However, the exact binding site of COMP on the collagen triple helix has not been described up to now. In this study we have identified a GXKGHR motif on the collagen II helix to bind to COMP, using a recombinantly expressed collagen II peptide library. This binding sequence is conserved throughout evolution and we demonstrate that TSP-4 binds to the same sequence. The identified binding motif overlaps with the recognition sites of many other collagen-binding partners (e.g. PEDF, Heparin) and also spans the lysine residues, which form collagen cross-links. COMP might thereby protect collagen helices from premature modification and cross-linking. Interestingly, this motif is only found in classical fibrillar collagens, although COMP is known to also bind other types. This might indicate that COMP has a unique interface for fibrillar collagens, thus making it an interesting target for the development of antifibrotic drugs.