bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study
Authors: Østergaard Lauge , Bruun Niels Eske , Voldstedlund Marianne , Arpi Magnus , Andersen Christian Østergaard , Schønheyder Henrik C , Lemming Lars , Rosenvinge Flemming , Valeur Nana , Søgaard Peter , Andersen Paal Skytt , Skov Robert , Chen Ming , Iversen Kasper , Gill Sabine , Lauridsen Trine Kiilerich , Dahl Anders , Oestergaard Louise Bruun , Povlsen Jonas Agerlund , Moser Claus , Bundgaard Henning , Køber Lars , Fosbøl Emil Loldrup 
Published: May 2019

Abstract

Aims
Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have been conducted on selected patient cohorts, yet unselected data are sparse. We aimed to investigate the prevalence of IE in BSIs with bacteria typically associated with IE.

Methods and results
By crosslinking nationwide registries from 2010 to 2017, we identified patients with BSIs typically associated with IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative staphylococci (CoNS) and examined the concurrent IE prevalence. A trend test was used to examine temporal changes in the prevalence of IE. In total 69 021, distributed with 15 350, 16 726, 19 251, and 17 694 BSIs were identified in the periods of 2010–2011, 2012–2013, 2014–2015, and 2016–2017, respectively. Patients with E. faecalis had the highest prevalence of IE (16.7%) followed by S. aureus (10.1%), Streptococcus spp. (7.3%), and CoNS (1.6%). Throughout the study period, the prevalence of IE among patients with E. faecalis and Streptococcus spp. increased significantly (P = 0.0005 and P = 0.03, respectively). Male patients had a higher prevalence of IE for E. faecalis, Streptococcus spp., and CoNS compared with females. A significant increase in the prevalence of IE was seen for E. faecalis, Streptococcus spp., and CoNS with increasing age.

Conclusion
For E. faecalis BSI, 1 in 6 had IE, for S. aureus BSI 1 in 10 had IE, and for Streptococcus spp. 1 in 14 had IE. Our results suggest that screening for IE seems reasonable in patients with E. faecalis BSI, S. aureus BSI, or Streptococcus spp. BSI.
The impact of a gender-specific physical activity intervention on the fitness and fatness profile of men in Ireland
Authors: Kelly Liam , Harrison Michael , Richardson Noel , Carroll Paula , Robertson Steve , Keohane Aisling , Donohoe Alex 
Published: May 2019

Abstract

Background
Amid increasing concerns about rising obesity rates and unhealthy lifestyle behaviours, physical activity (PA) is seen as a prophylactic to many chronic conditions affecting men. Men respond best to community-based PA programmes, using gender-specific promotional and delivery strategies. ‘Men on the Move’ (MOM) was developed on this basis and targeted inactive adult men in Ireland.

Methods
Sedentary men (n = 927; age = 50.7 ± 10.9 years; weight = 92.7 ± 16.0 kg; METS = 6.06 ± 2.13) were recruited across eight counties: four ‘intervention group’ (IG; n = 501) and four ‘comparison-in-waiting group’ (CG; n = 426). The MOM programme involved structured group exercise twice weekly for 12 weeks (W), along with health-related workshops with the groups maintained up to 52 W. Primary outcome measures [aerobic fitness, bodyweight and waist circumference (WC)] together with self-administered questionnaires were used to gather participant data at baseline, 12, 26 and 52 W.

Results
Results show a net positive effect on aerobic fitness, bodyweight and WC, with significant (P &lt; 0.05) net change scores observed in the IG compared to the CG (METS: 12 W = +2.20, 26 W = +1.89, 52 W = +0.92; weight: 12 W = −1.72 kg, 26 W = −1.95 kg, 52 W = −1.89 kg; WC: 12 W = −4.54 cm, 26 W = −2.69 cm, 52 W = −3.16 cm). The corresponding reduction in cardiovascular disease risk is particularly significant in the context of a previously inactive and overweight cohort. The high ‘dropout’ (42.7% presenting at 52 W), however, is of particular concern, with ‘dropouts’ having lower levels of aerobic fitness and higher bodyweight/WC at baseline.

Conclusions
Notwithstanding dropout issues, findings address an important gap in public health practice by informing the translational scale-up of a small controllable gender-specific PA intervention, MOM, to a national population-based PA intervention targeting inactive men.
Mechanical versus biological valve prosthesis for surgical aortic valve replacement in patients with infective endocarditis
Authors: Kytö Ville , Ahtela Elina , Sipilä Jussi , Rautava Päivi , Gunn Jarmo 
Published: May 2019

Abstract

OBJECTIVES
The optimal choice of valve prosthesis in surgical aortic valve replacement for infective endocarditis (IE) is controversial. We studied outcomes after mechanical versus biological prosthetic valve surgical aortic valve replacement in IE patients.

METHODS
All patients with native-valve IE aged 16–70 years undergoing mechanical or biological surgical aortic valve replacement in Finland, between 2004 and 2014, were retrospectively studied (n = 213). Outcomes were all-cause mortality, ischaemic stroke, major bleeding and aortic valve reoperation at 1 year and 5 years. Results were adjusted for baseline features (age, sex, comorbidity burden, atrial fibrillation, valvular stenosis, concomitant coronary artery bypass grafting, extension, urgency, year and centre of operation). Median follow-up was 5 years.

RESULTS
The 5-year mortality rate was 19.0% with mechanical prostheses and 34.8% with biological prostheses [hazard ratio (HR) 0.47, 95% confidence interval (CI) 0.23–0.92; P = 0.03]. Ischaemic stroke rates were 8.3% with mechanical prostheses and 16.8% with biological prostheses at 5 years (HR 0.21, CI 0.06–0.79; P = 0.01). Results were comparable in patients aged 16–59 and 60–70 years (interaction P = 0.84). Major bleeding within 5 years was similar between mechanical (11.3%) and biological valve (13.4%) groups (P = 0.95) with comparable rates of both gastrointestinal and intracranial bleeds. Reoperation rates at 5 years were 5.0% for mechanical prostheses and 9.2% for biological prostheses (P = 0.14). The 1-year ischaemic stroke rate was lower with mechanical prostheses (3.6% vs 11.6%, P =0.03), whereas mortality, major bleeding and reoperation rates were similar between groups.

CONCLUSIONS
The use of mechanical aortic valve is associated with lower mid-term mortality compared to biological prosthesis in patients with native-valve IE aged ≤70 years. Our results do not support the routine choice of a biological aortic valve prosthesis in this patient group.
Causes and predictors of mortality among Ghanaians hospitalised with endocrine disorders
Authors: Sarfo-Kantanka Osei , Ansah Eunice Oparebea , Kyei Ishmael , Barnes Nana Ama 
Published: May 2019

AbstractBackgroundEndocrine disorders have been noted to be on the increase in the developing world, but little is known about their outcomes on the African continent.MethodsWe conducted a retrospective longitudinal study to evaluate the demographic characteristics and determinants of endocrine-related mortality among adult patients over 9 y in a leading tertiary hospital in Ghana. We determined the predictors of inpatient mortality using Kaplan–Meier survival curves and Cox proportional hazard regression analysis.ResultsOverall, 6265 patients (9.7% of all medical admissions) were admitted with various endocrine disorders during the period. The most common endocrine cause of hospitalisation was diabetes mellitus (86.0%), followed in order of decreasing frequency by thyroid disorders (7.7%) and miscellaneous disorders (1.4%). The overall crude mortality rate of endocrine admissions was 16.7%. Death was predicted by increasing age with an adjusted hazard ratio of 1.25 (95% confidence interval 1.15 to 1.65) for every 10-y increase in age.ConclusionsAlmost one in six adults admitted with an endocrine disorder to a tertiary care centre in Ghana died in hospital, and many of the deaths were due to non-communicable disease complications. Enhanced public health disease prevention strategies and endocrine inpatient care processes are warranted.
Impact of prolonged maraviroc treatment on non-AIDS-related comorbidities in HIV-positive patients: a retrospective cohort study
Authors: Piconi Stefania , Foschi Antonella , Malagoli Andrea , Carli Federica , Zona Stefano , Milic Jovana , Ricci Elena Delfina , Rizzardini Giuliano , Guaraldi Giovanni 
Published: May 2019

Abstract

Objectives
This retrospective study evaluates the effect of maraviroc, the first CCR5 receptor antagonist, on non-AIDS-related comorbidity incidence and its impact on inflammatory and lipid parameters.

Methods
Seventy-four HIV patients on maraviroc treatment were compared with 312 patients never exposed to maraviroc (matched for sex, age and CD4 nadir).

Results
At baseline (T0), maraviroc patients presented a longer duration of HIV infection, a higher prevalence of comorbidities and a greater frequency of polypharmacy. Non-AIDS-defining disease incidence was lower in the maraviroc group than in the non-maraviroc group (without achieving statistical significance). Except triglycerides (TGL), which dropped only in the maraviroc group, inflammatory and immunological parameters did not significantly change in either group by the end of the study period (T3). At T3, high-sensitivity C-reactive protein (hsCRP) and high-density lipoprotein were inversely correlated in both groups (Spearman’s rho: maraviroc −0.30, P = 0.05; non-maraviroc −0.23, P = 0.0003). Only in the non-maraviroc group was the positive correlation between hsCRP and lipids observed both at T0 (hsCRP/low-density lipoprotein (LDL) +0.17, P = 0.004; hsCRP/total cholesterol +0.20, P = 0.0007; hsCRP/TGL +0.12, P = 0.04) and T3 (hsCRP/LDL +0.26, P < 0.0001; hsCRP/total cholesterol +0.24, P = 0.0001; hsCRP/TGL +0.15, P = 0.02). These correlations were not found in the maraviroc group. A significant positive correlation was found at T0 and at T3 between hsCRP and D-dimer in both groups (maraviroc: T0 +0.46, P = 0.0007; T3 +0.41, P = 0.006; non-maraviroc: T0 +0.17, P = 0.02; T3: +0.17, P = 0.017).

Conclusions
These data suggest a possible protective role of maraviroc in the incidence of non-AIDS-related comorbidities in a population with longer-lasting infection and allow us to hypothesize its role in the modulation of lipid-dependent inflammation.
Potential exists to change, through breeding, the yield of individual primal carcass cuts in cattle without increasing overall carcass weight1
Authors: Judge Michelle M , Pabiou Thierry , Murphy Jessica , Conroy Stephen B , Hegarty P J , Berry Donagh P 
Published: May 2019

AbstractThe ability to alter the morphology of cattle towards greater yields of higher value primal cuts has the potential to increase the value of animals at slaughter. Using weight records of 14 primal cuts from 31,827 cattle, the objective of the present study was to quantify the extent of genetic variability in these primal cuts; also of interest was the degree of genetic variability in the primal cuts adjusted to a common carcass weight. Variance components were estimated for each primal cut using animal linear mixed models. The coefficient of genetic variation in the different primal cuts ranged from 0.05 (bavette) to 0.10 (eye of round) with a mean coefficient of genetic variation of 0.07. When phenotypically adjusted to a common carcass weight, the coefficient of genetic variation of the primal cuts was lesser ranging from 0.02 to 0.07 with a mean of 0.04. The heritability of the 14 primal cuts ranged from 0.14 (bavette) to 0.75 (topside) with a mean heritability across all cuts of 0.48; the heritability estimates reduced, and ranged from 0.12 (bavette) to 0.56 (topside), when differences in carcass weight were accounted for in the statistical model. Genetic correlations between each primal cut and carcass weight were all ≥0.77; genetic correlations between each primal cut and carcass conformation score were, on average, 0.59 but when adjusted to a common carcass weight, the correlations weakened to, on average, 0.27. The genetic correlations among all 14 primal cut weights was, on average, strong (mean correlation of 0.72 with all correlations being ≥0.37); when adjusted to a common carcass weight, the mean of the genetic correlations among all primal cuts was 0.10. The ability of estimated breeding values for a selection of primal cuts to stratify animals phenotypically on the respective cut weight was demonstrated; the weight of the rump, striploin, and fillet of animals estimated to be in the top 25% genetically for the respective cut, were 10 to 24%, 12 to 24%, and 7 to 17% heavier than the weight of cuts from animals predicted to be in the worst 25% genetically for that cut. Significant exploitable genetic variability in primal carcass cuts was clearly evident even when adjusted to a common carcass weight. The high heritability of many of the primal cuts infers that large datasets are not actually required to achieve high accuracy of selection once the structure of the data and the number of progeny per sire is adequate.
If the Chair Fits: Sexism in American Office Furniture Design
Authors: Kaufmann-Buhler Jennifer 
Published: May 2019

Abstract
This article examines the ways in which gendered bodies and gendered ideas about labour were built into American office furniture by way of human factors from the 1960s through the early 1990s. Using an analysis of chairs and desks, including their forms and technical dimensions, the author argues that executive and secretarial furniture, in particular, encoded exaggerated and idealized gendered bodies in their design and excluded bodies that did not fit the expected gendered norms. The persistence of this convention, even in the design of ergonomic chairs which first appeared in the 1970s, reproduced sexism in organizational hierarchy and inscribed in furniture gendered assumptions of labour and gendered ideals of leadership.
A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition)
Authors:   Head and Neck Cancer Study Group (HNCSG), Monden Nobuya , Asakage Takahiro , Kiyota Naomi , Homma Akihiro , Matsuura Kazuto , Hanai Nobuhiro , Kodaira Takeshi , Zenda Sadamoto , Fujii Hirofumi , Tahara Makoto , Yokota Tomoya , Akimoto Tetsuo , Iwae Shigemichi , Onitsuka Tetsuro , Ogawa Takenori , Okano Susumu , Takahashi Shunji , Shimizu Yasushi , Yonezawa Koichiro , Hayashi Ryuichi 
Published: May 2019

Abstract
A number of major modifications were made to the classification of head and neck carcinomas in the eighth edition of the American Joint Committee on Cancer, Cancer Staging Manual and Union for International Cancer Control TNM classification of Malignant Tumors. These modifications were aimed at improving the prognosis prediction accuracy of the system. In this article, we review the new edition of the TNM classification system. Among the several changes in the new system, a separate algorithm for p16-positive oropharyngeal carcinoma was included, as were new chapters on ‘Head and Neck Skin Carcinoma’ and ‘Unknown Primary Carcinoma—Cervical Nodes.’ Changes to Tumor (T) classification were made by introducing the depth of invasion of oral carcinoma, whereas changes to Node (N) classification were made by adding extra-nodal extension. It is believed that these changes will help improve the accuracy of the system in the prediction of prognosis. However, it is necessary to verify their validity through further clinical research.
Deep convolutional neural network for reduction of contrast-enhanced region on CT images
Authors: Sumida Iori , Magome Taiki , Kitamori Hideki , Das Indra J , Yamaguchi Hajime , Kizaki Hisao , Aboshi Keiko , Yamashita Kyohei , Yamada Yuji , Seo Yuji , Isohashi Fumiaki , Ogawa Kazuhiko 
Published: May 2019

Abstract
This study aims to produce non-contrast computed tomography (CT) images using a deep convolutional neural network (CNN) for imaging. Twenty-nine patients were selected. CT images were acquired without and with a contrast enhancement medium. The transverse images were divided into 64 × 64 pixels. This resulted in 14 723 patches in total for both non-contrast and contrast-enhanced CT image pairs. The proposed CNN model comprises five two-dimensional (2D) convolution layers with one shortcut path. For comparison, the U-net model, which comprises five 2D convolution layers interleaved with pooling and unpooling layers, was used. Training was performed in 24 patients and, for testing of trained models, another 5 patients were used. For quantitative evaluation, 50 regions of interest (ROIs) were selected on the reference contrast-enhanced image of the test data, and the mean pixel value of the ROIs was calculated. The mean pixel values of the ROIs at the same location on the reference non-contrast image and the predicted non-contrast image were calculated and those values were compared. Regarding the quantitative analysis, the difference in mean pixel value between the reference contrast-enhanced image and the predicted non-contrast image was significant (P < 0.0001) for both models. Significant differences in pixels (P < 0.0001) were found using the U-net model; in contrast, there was no significant difference using the proposed CNN model when comparing the reference non-contrast images and the predicted non-contrast images. Using the proposed CNN model, the contrast-enhanced region was satisfactorily reduced.
Maternal nesting behaviour in city dragons: a species with temperature-dependent sex determination
Authors: Jackson Nicola , Cristescu Romane H , Piza-Roca Carme , Littleford-Colquhoun Bethan L , Strickland Kasha , Frère Céline H 
Published: May 2019

Abstract
Urban environments present some of the greatest challenges to species survival. This is particularly true for species that exhibit thermally sensitive traits, such as temperature-dependent sex determination (TSD). This is because urban environments not only present species with entirely novel ecosystems, but species will also experience increased temperatures. These temperature increases may result not only in offspring mortality, but also skewed population sex ratios. To persist in cities, urban dwellers with TSD will therefore need to adjust the temperature of the nesting environment, either through phenotypic plasticity or rapid evolution through natural selection. Here, we investigate the nesting ecology of a long-lived, urban dwelling reptile, the eastern water dragon (Intellagama lesueurii), to understand how a TSD species may respond to urban environments. Based on data collected from 72 nests over 2 nesting seasons, we show that city dragons not only dug significantly deeper nests than previously observed across their natural riparian habitat, but also nested in novel substrates. Furthermore, we observed a behaviour not previously described in this species, where mothers travel outside of their core home range to nest. This excursion behaviour potentially represents a greater maternal investment and is linked to the selection of specific microhabitats.
Probing G-quadruplex topologies and recognition concurrently in real time and 3D using a dual-app nucleoside probe
Authors: Nuthanakanti Ashok , Ahmed Ishtiyaq , Khatik Saddam Y , Saikrishnan Kayarat , Srivatsan Seergazhi G 
Published: May 2019

Abstract
Comprehensive understanding of structure and recognition properties of regulatory nucleic acid elements in real time and atomic level is highly important to devise efficient therapeutic strategies. Here, we report the establishment of an innovative biophysical platform using a dual-app nucleoside analog, which serves as a common probe to detect and correlate different GQ structures and ligand binding under equilibrium conditions and in 3D by fluorescence and X-ray crystallography techniques. The probe (SedU) is composed of a microenvironment-sensitive fluorophore and an excellent anomalous X-ray scatterer (Se), which is assembled by attaching a selenophene ring at 5-position of 2′-deoxyuridine. SedU incorporated into the loop region of human telomeric DNA repeat fluorescently distinguished subtle differences in GQ topologies and enabled quantify ligand binding to different topologies. Importantly, anomalous X-ray dispersion signal from Se could be used to determine the structure of GQs. As the probe is minimally perturbing, a direct comparison of fluorescence data and crystal structures provided structural insights on how the probe senses different GQ conformations without affecting the native fold. Taken together, our dual-app probe represents a new class of tool that opens up new experimental strategies to concurrently investigate nucleic acid structure and recognition in real time and 3D.
Smokers’ Perceptions of Cigarette Packaging With Audio Warning Messages: A Focus Group Study in Scotland
Authors: Mitchell Danielle , Moodie Crawford , Bauld Linda 
Published: May 2019

Abstract

Aims
The use of audio pack cues or messages is a recent trend in packaging design. There is scope to use audio technology to communicate health and cessation messages via cigarette packaging. We explored how smokers responded to cigarette packs which played audio health messages.

Methods
Twenty focus groups were conducted in Scotland in 2015 with smokers (n = 120) segmented by age (16–17, 18–24, 25–35, 36–50, &gt;50), gender and social grade. Perceptions of cigarette packs which played audio warnings were explored, with four messages used: (1) a cessation message with a quitline number, (2) mortality message, (3) fertility message, and (4) message about ageing skin.

Results
Audio warnings were thought to increase message impact, particularly among younger smokers, as they would be hard to ignore or avoid, and repetition may lead to the messages being memorized. The warnings were considered annoying or embarrassing, and participants suggested they may discard the packs and use alternative storage. Some participants suggested that the audio warnings were off-putting and may alter their smoking behavior, with the mortality message deemed most effective and was considered relatable and felt personal. Older smokers were least likely to believe that audio warnings would affect their smoking behavior, although some thought that they may enhance cessation attempts among smokers seeking to quit, and could deter new or potential smokers, for example, young people.

Conclusions
Cigarette packs with audio messaging may have a role to play, now or in the future, as a novel way of communicating health and cessation information.

Implications
There is a lack of research exploring smokers’ perceptions of cigarette packs which play audio health messages. This focus group study provides an understanding of smokers’ immediate responses to cigarette packs which played a short health message when opened. Smokers generally viewed them as annoying or embarrassing, and some suggested the use of alternative storage. Audio warnings were thought to increase message salience, memorability, and impact, for younger smokers in particular, and some suggested that they be off-putting for themselves or others.