bluuebunny/crossref_metadata_2025_split huggingface dataset:
New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma
Authors: Verhoeven Jeroen , Hulpia Fabian , Kersemans Ken , Bolcaen Julie , De Lombaerde Stef , Goeman Jan , Descamps Benedicte , Hallaert Giorgio , Van den Broecke Caroline , Deblaere Karel , Vanhove Christian , Van der Eycken Johan , Van Calenbergh Serge , Goethals Ingeborg , De Vos Filip 
Published: February 2019

AbstractThe use of O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET) as a positron emission tomography (PET) tracer for brain tumor imaging might have some limitations because of the relatively low affinity for the L-type amino acid transporter 1 (LAT1). To assess the stereospecificity and evaluate the influence of aromatic ring modification of phenylalanine LAT1 targeting tracers, six different fluoroalkylated phenylalanine analogues were synthesized. After in vitro Ki determination, the most promising compound, 2-[18F]-2-fluoroethyl-l-phenylalanine (2-[18F]FELP), was selected for further evaluation and in vitro comparison with [18F]FET. Subsequently, 2-[18F]FELP was assessed in vivo and compared with [18F]FET and [18F]FDG in a F98 glioblastoma rat model. 2-[18F]FELP showed improved in vitro characteristics over [18F]FET, especially when the affinity and specificity for system L is concerned. Based on our results, 2-[18F]FELP is a promising new PET tracer for brain tumor imaging.
On the emerging relationship between the stratospheric Quasi-Biennial oscillation and the Madden-Julian oscillation
Authors: Klotzbach P. , Abhik S. , Hendon H. H. , Bell M. , Lucas C. , G. Marshall A. , Oliver E. C. J. 
Published: February 2019

AbstractA strong relationship between the quasi-biennial oscillation (QBO) of equatorial stratospheric winds and the amplitude of the Madden-Julian oscillation (MJO) during the boreal winter has recently been uncovered using observational data from the mid-1970s to the present. When the QBO is in its easterly phase in the lower stratosphere, it favors stronger MJO activity during boreal winter, while the MJO tends to be weaker during the westerly phase of the QBO. Here we show using reconstructed indices of the MJO and QBO back to 1905 that the relationship between enhanced boreal winter MJO activity and the easterly phase of the QBO has only emerged since the early 1980s. The emergence of this relationship coincides with the recent cooling trend in the equatorial lower stratosphere and the warming trend in the equatorial upper troposphere, which appears to have sensitized MJO convective activity to QBO-induced changes in static stability near the tropopause. Climate change is thus suggested to have played a role in promoting coupling between the MJO and the QBO.
Quantum walk hydrodynamics
Authors: Hatifi Mohamed , Di Molfetta Giuseppe , Debbasch Fabrice , Brachet Marc 
Published: February 2019

AbstractA simple Discrete-Time Quantum Walk (DTQW) on the line is revisited and given an hydrodynamic interpretation through a novel relativistic generalization of the Madelung transform. Numerical results show that suitable initial conditions indeed produce hydrodynamical shocks and that the coherence achieved in current experiments is robust enough to simulate quantum hydrodynamical phenomena through DTQWs. An analytical computation of the asymptotic quantum shock structure is presented. The non-relativistic limit is explored in the Supplementary Material (SM).
Metallophore profiling of nitrogen-fixing Frankia spp. to understand metal management in the rhizosphere of actinorhizal plants
Authors: Deicke Michael , Mohr Jan Frieder , Roy Sébastien , Herzsprung Peter , Bellenger Jean-Philippe , Wichard Thomas 
Published: February 2019

Abstract
Frankia spp. are widespread nitrogen-fixing soil bacteria, which often live in symbiosis with a broad range of hosts. Metal homeostasis plays a crucial role in the success of the symbiosis regarding the acquisition of essential trace metals and detoxification of potentially toxic elements. We have hypothesised that Frankia releases many organic ligands with a broad spectrum of affinity for essential and toxic metals. We coined the term ‘ligandosphere’ to describe the entirety of excreted metal complexing agents and ligands derived from the dissolved organic matter. Using metal isotope-coded profiling (MICP); metallophores of physiological important and toxic trace metals were identified by the addition of stable metal isotope pairs such as 54Fe/58Fe, 63Cu/65Cu, 66Zn/68Zn or 95Mo/98Mo. Liquid chromatography coupled to a mass spectrometer revealed strong variations of the metallophore profile in between the 14 test-strains. In total, about 83 organic ligands were identified as binding to one of the tested metals. The predicted sum formula of the major Fe binding ligands and MS/MS experiments suggested that several metallophore candidates have a similar molecular backbone. Growth experiments with a hyper-producer of metallophores revealed a positive relationship between metallophore production and the concentration of Cu in the growth medium. The present study provides the first comprehensive overview of the complexity of Frankia’s ligandosphere. It opens a path to a deeper understanding of mechanisms that regulate metal homeostasis in frankiae. Deciphering these mechanisms is important since the fitness of actinorhizal plants and their potential in ecological restoration relies heavily on their symbiosis with frankiae.
Rethinking Assessment of Student Clinician Learning: A Collaborative Faculty Effort
Authors: Meder Allison M. , Wegner Jane R. 
Published: February 2019

Purpose
This article describes a collaborative clinical faculty effort to develop and pilot observation-based formative assessment tools for faculty use during clinical supervision. The purposes of the pilot project were to create the tools and to evaluate faculty perceptions of developing and using the assessment tools.

Method
Data were collected using a rating scale, a focus group, and a questionnaire. Two formative assessment tools were designed following qualitative data analysis, and faculty subsequently piloted the tools in the clinic.

Results
Three clinical faculty who piloted the tools reported positive feedback regarding the tool development and implementation processes. Overall, clinical faculty perceived that the assessment tools improved their formative feedback to students.

Conclusion
Limitations, future directions, and implications are presented with recommendations for investigations in other settings.
HADES RV Programme with HARPS-N at TNG
Authors: González-Álvarez E. , Micela G. , Maldonado J. , Affer L. , Maggio A. , Lanza A. F. , Covino E. , Benatti S. , Bignamini A. , Cosentino R. , Damasso M. , Desidera S. , González Hernández J. I. , Martínez-Fiorenzano A. , Pagano I. , Perger M. , Piotto G. , Pinamonti M. , Rainer M. , Rebolo R. , Ribas I. , Scandariato G. , Sozzetti A. , Suárez Mascareño A. , Toledo-Padrón B. 
Published: February 2019

Aims. We extend the relationship between X-ray luminosity (Lx) and rotation period (Prot) found for main-sequence FGK stars, and test whether it also holds for early M dwarfs, especially in the non-saturated regime (Lx ∝ Prot−2) which corresponds to slow rotators.
Methods. We use the luminosity coronal activity indicator (Lx) of a sample of 78 early M dwarfs with masses in the range from 0.3 to 0.75 M⊙ from the HArps-N red Dwarf Exoplanet Survey (HADES) radial velocity (RV) programme collected from ROSAT and XMM-Newton. The determination of the rotation periods (Prot) was done by analysing time series of high-resolution spectroscopy of the Ca II H & K and Hα activity indicators. Our sample principally covers the slow rotation regime with rotation periods from 15 to 60 days.
Results. Our work extends to the low mass regime the observed trend for more massive stars showing a continuous shift of the Lx∕Lbol versus Prot power law towards longer rotation period values, and includes a more accurate way to determine the value of the rotation period at which the saturation occurs (Psat) for M dwarf stars.
Conclusions. We conclude that the relations between coronal activity and stellar rotation for FGK stars also hold for early M dwarfs in the non-saturated regime, indicating that the rotation period is sufficient to determine the ratio Lx∕Lbol.
Funktionelle Kniestabilität im Handball: Ein unverzichtbares Kriterium für sicheren Sport
Authors: Rühlemann Alina , Mayer Constantin Ulrich , Götte Lennard , Behringer Michael , Jäger Marcus 
Published: February 2019

ZusammenfassungVerschiedene Untersuchungen in den vergangenen Jahren haben gezeigt, dass innerhalb der Ballsportarten Handballspieler einem besonders hohen Verletzungsrisiko ausgesetzt sind. Dabei ist das Kniegelenk die am häufigsten verletzte Körperregion und ein Riss des vorderen Kreuzbandes die häufigste Verletzung am Knie. Um Folgeschädigungen oder erneuten Verletzungen vorzubeugen, ist eine gute situative Kniestabilität entscheidend. Diese kann nicht nur Verletzungen vorbeugen, sondern ist auch ausschlaggebend für die Optimierung handballspezifischer Bewegungsabläufe und eine verletzungsfreie Ausübung des Sports. Obwohl es zahlreiche Studien zu Verletzungen im Handball gibt (meist an Profisportlern durchgeführt), ist das Forschungsfeld in Bezug auf die situative Kniestabilität defizitär. Dieser Beitrag gibt einen Überblick über den aktuellen Forschungsstand. Zudem werden aktuelle Präventionsansätze aufgegriffen und diskutiert.
Diabetes und Herzinsuffizienz
Authors: Schütt Katharina , Marx Nikolaus , Müller-Wieland Dirk 
Published: February 2019

ZUSAMMENFASSUNGDas metabolische Syndrom ist in aller Regel mit einer Insulinresistenz und einer viszeralen Fettverteilung assoziiert, die bei der Entstehung klinischer Facetten des metabolischen Syndroms, zum Beispiel der Erhöhung des arteriellen Blutdrucks und der Dyslipidämie, eine entscheidende Rolle spielen. In Bezug auf das kardiovaskuläre System gibt es zunehmend Hinweise, dass eine Insulinresistenz und ektope Lipidablagerung am Herzen, insbesondere das epikardiale Fett, mit Inflammation, Fibrosierung und eingeschränkter diastolischer Funktion bzw. Herzinsuffizienz assoziiert sein können. Die klinische Prognose von Patienten mit metabolischem Syndrom und Herzinsuffizienz ist sehr schlecht, und daher könnten diese neuen Zusammenhänge zwischen Adipositas, Insulinresistenz, Fettverteilung, Inflammation und Herzfunktion künftig eine Rolle bei einer differenzierten kardiometabolischen Früherkennung und Therapie von Risikoindividuen sein.
Increase of pregnancy rate after multiple periovulatory
inseminations in mares
Authors: Huber Desiree , Amsler Evelyne , Vidondo Beatriz , Kaeser Rebekka , Wespi Bettina , Sieme Harald , Burger Dominik 
Published: February 2019

Abstract
Objective There exist differences in the reproductive behavior of
stallions and mares under free-running and domestic in-hand breeding conditions.
Contrary to artificial insemination programs, a stallion mates a mare multiple
times per estrus under natural conditions. The objective of this study was to
determine if multiple periovulatory artificial inseminations (MI), four times in
two different time intervals instead of two, would result in increased pregnancy
outcome or higher incidences of breeding induced endometritis.
Material and methods Eighty-two estrous mares were allocated randomly to
one of three experimental groups. They were administered intramuscular
deslorelin (1.25 mg) to induce ovulation, and 24 hours later, they were
inseminated either twice (group DI), four times in relatively short intervals
(group MISI) or four times in relatively long intervals (MILI), after division
of one commercial insemination dose (either frozen-thawed or chilled-warmed
semen) into two or four portions, respectively. Uterine sampling for
bacteriological and cytological analysis was conducted directly before the first
insemination and 24 hours after the last insemination.
Results Mares of the MI groups showed a higher pregnancy rate with
frozen-thawed semen than mares of the DI group. There was no difference in
bacteriological and cytological results between the three groups. In addition,
mares of the MISI group showed less intrauterine fluid accumulation 24 hours
after the last insemination than mares of the DI and MILI groups.
Conclusion and clinical relevance We suggest that multiple periovulatory
inseminations with frozen-thawed semen in a close time frame to ovulation lead
to an increase of pregnancy results per cycle, and that they do not lead to
impaired inflammatory reactions of the uterus in healthy fertile mares.
Adipositasambulanz in Leipzig
Authors: Sergeyev E. , Böttcher M. , Vogel A. , Cämmerer J. , Stein R. , Körner A. , Kiess W. 
Published: February 2019

ZusammenfassungIn der Adipositasambulanz der Universitätskinderklinik Leipzig werden sowohl individuelle als auch standardisierte Therapiestrategien für Kinder und Jugendliche mit Adipositas angewendet. Die Therapieprogramme basieren auf der Steigerung der Bewegung, Verhaltenstherapie, Ernährungsberatung und psychologischer Betreuung. Psychosoziale familiäre Problemkonstellationen erhöhen das Risiko der Adipositasentstehung und haben einen negativen Einfluss auf den Behandlungserfolg. Bariatrische Chirurgie zeigt gute Ergebnisse bezüglich der Gewichtsreduktion postoperativ, jedoch fehlen Langzeitdaten, um besser das langfristige Outcome bewerten zu können. Effektive Strategien zur Adipositas-Prävention sind notwendig.
KCNA4 Gene Variant is Auxiliary in Endurance Running Performance Level
Authors: Flecha-Velazquez Keven , Fahey Thomas , Martínez Juan , Lopez-Taylor Juan , Rivera Miguel 
Published: February 2019

AbstractThe present is an observational study following a genetic epidemiology model using a case-control design. We tested the hypothesis of an association between the prevalence of the genotypic and allelic frequencies distribution of the potassium voltage-gated channel of the shaker related subfamily member 4 gene (KCNA4) rs1323860 (C/T transition) and endurance performance level in Hispanic male marathon runners (MR). The subjects (n=1876) were adult Hispanic male MR. Fast-MR (cases; n=938) were finishers in the top 3rd percentile. Slow MR (controls; n=938) were finishers in the lowest 3rd percentile of their respective age. Genomic DNA was purified from a whole blood sample. Polymerase chain reaction was used to amplify a KCNA4 SNP which consists of a C/T (rs1323860) transition. The observed genotype frequencies, in both Cases and Controls, met Hardy-Weinberg equilibrium (X2, P≥0.05). Genotype and allele frequencies were statistically different (P<0.01) between cases and controls. Odds ratio revealed that the C allele was 1.33 times more likely prevalent in the cases than in the controls (95% CI; 1.17, 1.51; P<0.001). The magnitude of the statistical power for the present study was 0.86. In conclusion, the findings strongly suggest that KCNA4 gene rs1323860 (C/T transition) is auxiliary in the complex phenotype of endurance running performance level in Hispanic male marathon runners.
Remission of diabetes mellitus after ovariohysterectomy in
a guinea pig with ovarian cysts
Authors: Kreilmeier-Berger Theresa , Guija-De-Arespacochaga Abigail , Bilek Andrea , Künzel Frank 
Published: February 2019

AbstractA 3-year-old intact female guinea pig was presented with a history of polydipsia,
polyphagia, and hyperactivity combined with non-pruritic hair loss. The physical
examination revealed bilateral alopecia mainly including the flanks and the
ventral abdomen. Bilateral rounded masses just caudal to the kidneys were
detected on abdominal palpation. Abdominal ultrasound examination confirmed
bilateral ovarian cysts and an enlarged uterus with cystic lesions. Blood
biochemistry revealed highly increased glucose and fructosamine concentrations.
The final diagnoses were diabetes mellitus, bilateral ovarian cysts, and
pathologic changes of the uterus. The guinea pig underwent ovariohysterectomy.
After surgery, diabetes mellitus and all of the existing clinical signs were
fully resolved. A causal relationship between hormonally active ovarian cysts
and diabetes mellitus that commonly present independently from each other in the
guinea pig can be strongly assumed in the present case. In suspicious cases of
gestagen-induced diabetes mellitus ovariohysterectomy could be considered a
potential treatment option in guinea pigs.
First-Year Ophthalmology Residency Call Structure and Its Association with Resident Anxiety and Confidence
Authors: McCoskey Makayla , Shafer Brian , Nti Akosua , Ying Gui-Shuang , Tapino Paul , Pan Wei , Addis Victoria 
Published: February 2019

Purpose The main purpose of this article is to characterize methods for preparing first-year ophthalmology residents for call and to evaluate the association between call structure and anxiety levels.
Methods Data on call structure and preparatory courses were collected by a national online survey of residency program directors and first-year residents in 2016 and 2017. Anxiety was assessed using the Endler Multidimensional Anxiety Scale, and confidence in evaluating and managing critical diagnoses on call was evaluated using a modified Likert-type scale.
Results In 2016, 132 first-year ophthalmology residents (28% of 465 total) responded to the survey, and in 2017, 103 first-year residents (22% of 469 total) responded, for a total of 235 residents participating. About 97.4% of residents reported that their residency program had a buddy call system, and 73.2% reported that their residency offered a preparatory course at the beginning of residency. In the resident cohort from 2017, there was a statistically significant association between length of buddy call duration and cognitive worry anxiety level (p = 0.01) with the lowest mean anxiety scores reported among those whose buddy call system lasted between 9 and 12 weeks. Higher confidence in making critical diagnoses on call was significantly associated with lower anxiety scores (p < 0.05 for all surveyed diagnoses). In the 2016 cohort, the mean cognitive worry score was significantly lower in those who had a preparatory course than those who did not (17.6 vs 22.2, p = 0.02), as was the mean overall anxiety score (33.8 vs 40.8, p = 0.04).
Conclusion Buddy call and preparatory courses are associated with less anxiety and improved confidence among residents on call.
Midflexion Instability in Primary Total Knee Arthroplasty
Authors: Nagle Matthew , Glynn Aaron 
Published: February 2019

AbstractInstability is one of the most common causes of failure in total knee arthroplasty. Traditionally, it has been classified into three types: extension instability, flexion instability, and hyperextension instability. More recently, a fourth type of instability has been proposed, namely “midflexion instability” (MFI). Whether MFI is distinct from the aforementioned types of instability is contentious, and at present, the condition is yet to be clearly defined. This article reviews the current literature and identifies the best available evidence relevant to the concept of MFI. Our aim is to present an overview of the proposed causes and mechanisms for MFI. By doing so, we also aim to provide a focus on how MFI presents, whether it is indeed a discrete form of instability, and if it influences clinical results.
Function and Knee Range of Motion Plateau Six Months following Lateral Tibial Plateau Fractures
Authors: Christiano Anthony V. , Pean Christian A. , Kugelman David N. , Konda Sanjit R. , Egol Kenneth A. 
Published: February 2019

AbstractThe purpose of this study is to determine when functional outcome no longer improves following tibial plateau fracture. A patient series of operatively treated tibial plateau fractures was reviewed. Patients were evaluated using the short musculoskeletal function assessment (SMFA), range of motion (ROM) assessment, and pain levels at visual analog scale (VAS) at 3, 6, and 12 months postoperatively. Fractures were classified by the Schatzker's classification using preoperative imaging. The case series was divided into two groups based on fracture patterns. Friedman's tests were conducted to determine if there were differences in SMFA, ROM, or VAS throughout the postoperative course. A total of 117 patients with tibial plateau fractures treated operatively, with complete follow-up and without complication, were identified. Seventy-seven patients (65.8%) sustained lateral tibial plateau fractures (Schatzker's I–III). Friedman's test demonstrated significant differences in SMFA (p < 0.0005) and ROM (p < 0.0005) at the three time points. Post hoc analysis demonstrated a significant difference in SMFA (p < 0.0005) and ROM (p = 0.003) between 3 and 6 months postoperatively but no significant difference in either metric between 6 and 12 months postoperatively. Friedman's test demonstrated no significant difference in VAS postoperatively (p = 0.210). Forty patients (34.2%) sustained medial or bicondylar tibial plateau fractures (Schatzker's IV–VI). Friedman's test demonstrated significant differences in SMFA (p < 0.0005) and ROM (p < 0.0005) at the three time points. Post hoc analysis demonstrated a strong trend toward significance in SMFA between 3 and 6 months postoperatively (p = 0.088), and demonstrated a significant difference between 6 and 12 months postoperatively (p = 0.013). ROM was found to be significantly different between 3 and 6 months postoperatively (p = 0.010), but no difference was found between 6 and 12 months postoperatively (p = 0.929). Friedman's test demonstrated no significant difference in VAS postoperatively (p = 0.941). In this cohort, no significant difference in function, ROM, or pain level exists between 6 and 12 months after treatment of lateral tibial plateau fractures. However, there are significant improvements in function for at least 1 year following medial or bicondylar tibial plateau fractures.
Study abroad homestay versus dormitory
Authors: George Angela 
Published: February 2019

Abstract
This article addresses differences in 25 study abroad students that reside in the dormitory, primarily with other native English speakers, to those that live with local host families during a 13-week semester in Central Spain. In addition to completing four tasks to elicit three regional features ([θ], [χ], and vosotros) the participants, all majors or minors of Spanish, also completed questionnaires and interviews to elicit a variety of social and individual factors, including social networks and amount of contact with Spanish and English. Living experience accounts for differences in the production of one feature in one task at the middle of the semester. In addition, those students that lived with a host family exhibited more contact with Spanish and completed fewer international trips on weekends. The study not only discusses ways to increase contact in Spanish but also ways to improve the study abroad experience in general.