bluuebunny/crossref_metadata_2025_split huggingface dataset:
C-65 Transdiagnostic Factors of Social Impairment in Comorbid Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder
Authors: Garagozzo A , Katz L , Scott M , Hunter S 
Published: August 2019

Abstract

Objective
Comorbid Autism Spectrum Disorder (ASD) and ADHD are associated with greater symptom severity, including social impairment. Furthering work by Lerner, Pothoff, and Hunter (2015), we sought to identify unique and shared factors that contribute to parent-reported social deficits in children with ADHD, ASD, and ADHD+ASD. We hypothesized attention, hyperactivity, and motor skills would predict social deficits in ADHD, while functional communication and motor skills would predict social deficits in ASD; and additively, all factors would predict social deficits in ADHD+ASD.

Method
Utilizing a clinical database, we identified 236 participants (4-21 years; Mage = 10.6; 71% male; 28% African American; FSIQ M = 94.31) with diagnoses of ADHD, ASD, and ADHD+ASD. We examined FSIQ from the WISC-4/5, WPPSI-3, or DAS-2, motor skills and social impairment from the SIB-R and attention, hyperactivity, and functional communication from the BASC-2/3.

Results
Using hierarchical linear regression and controlling for FSIQ, hypotheses were partially supported. FSIQ was controlled for in each group. For ADHD, hyperactivity, functional communication, and motor skills contributed significantly to the model (p < .001), while for ASD, motor skills contributed significantly to the model (p < .001). For ASD + ADHD, functional communication and motor skills contributed significantly to the model (p < .001)

Conclusion
Results support previous findings that motor deficits and functional communication are associated with social impairment in children with ADHD and ASD, independently and comorbidly. This suggests that targeting motor dysfunction and functional communication concurrently may be effective for improving social interaction skills in children with ADHD +ASD.
C-68 Expanding Pediatric Performance Validity Tests
Authors: McIntyre K 
Published: August 2019

Abstract

Objective
Effort testing with children has started to gain traction in the literature. The following case presents data from several number recall tasks similar to the Wechsler Digit Span and may expand the opportunities for embedded performance validity tests (PVTs).

Method
For the purpose of psychoeducational testing, a comprehensive battery of standardized neuropsychological tests was administered, including visual and auditory attention, language, visual-motor and fine motor skills, visual and auditory processing, executive functioning, and academics.

Results
The child showed impaired performance on Number Recall from the Kaufman Assessment Battery for Children, 2nd Edition (KABC-II) and Memory for Digits on the Comprehensive Test of Phonological Processing, 2nd Edition (CTOPP-2) that met the Weschler Digit Span cutoff indicative of poor effort. Evidence of Ganser symptoms (e.g., nearly correct or approximate answers) was present on math calculation performance on the Woodcock Johnson Tests of Achievement, 4th Edition (WJTA-IV). Further, apparently deliberate markings of “X” solely on his incorrect responses on a dichotomous (yes/no) reading task also suggested deliberate feigning of low reading skills.

Conclusions
This case highlights the importance of effort testing in children, especially as poor effort was not apparent to the examiner, nor did there appear to be any obvious gain. Comparing data on tasks similar to already established PVTs may help expand opportunities to test effort systematically and frequently throughout a neuropsychological evaluation, and has implications for other professionals (e.g., School Psychologists, Speech Language Pathologists, etc.) who evaluate children.
A-24 Metacognition and behavioral regulation associated with distinct connectivity patterns in autism spectrum disorder
Authors: Bednarz H , Kana R 
Published: August 2019

Abstract

Objective
Executive function (EF) deficits are well documented in children with autism spectrum disorder (ASD)1-2 and are commonly measured clinically using parent ratings3. No studies have investigated whether parent ratings of EF predict brain connectivity in ASD.

Aim
Examine whether the Behavior Rating Inventory of Executive Function (BRIEF) predicts functional brain connectivity in ASD.

Method
Resting-state fMRI and behavioral data were obtained from the Autism Brain Imaging Data Exchange (ABIDE-II) database6 (n = 106 ASD, ages 5-13). ROI-to-ROI (Region of Interest) connectivity was computed for 132 ROIs spanning the whole brain, defined using Conn Toolbox. Multiple regression analyses examined the effect of BRIEF metacognition on connectivity while controlling for BRIEF behavioral regulation, and vice versa. Age, sex, and full-scale IQ were included as covariates. FDR correction was used (p < 0.05).

Results
More severe deficits in metacognition were associated with stronger connectivity between the left hippocampus and several ROIs, including the cerebellum and planum temporale. More severe deficits in metacognition were associated with weaker right hippocampus – right frontal pole connectivity. More severe deficits in behavioral regulation were associated with stronger connectivity between subcortical regions (i.e., thalamus, putamen, and caudate) and regions involved in motor (superior frontal gyrus) and limbic systems (cingulate gyrus). More severe behavioral regulation deficits were associated with weaker cerebellar-cerebellar connectivity.

Conclusions
Findings suggest that parent-ratings of metacognitive abilities in children with ASD are associated with hippocampal connectivity, while behavioral regulation abilities are associated with thalamic and striatum connections. These results build upon previous studies of metacognition and behavioral regulation 5,6.
A-25 Paced Auditory Serial Addition Test in Individuals with Cocaine Versus Methamphetamine Dependence
Authors: Pollard A , Hauson A , Stelmach N , Sarkissians S , Walker A , Cabral C , Wollman S , Hall M 
Published: August 2019

Abstract

Objective
Research suggests that cocaine and methamphetamine differ in their impact on executive functions (EF). The Paced Auditory Serial Addition Test (PASAT) is used to assess working memory; a component of EF. The purpose of this meta-analysis was to examine the difference between the effect of these two drugs on PASAT scores.

Data Selection
Three researchers independently searched nine databases (e.g., PsycINFO, Pubmed, ProceedingsFirst), extracted required data, and calculated effect sizes. Inclusion criteria identified studies that had (a) compared cocaine or methamphetamine dependent groups to healthy controls and (b) matched groups on either age, education, or IQ (at least 2 out of 3). Studies were excluded if participants were reported to have Axis I diagnoses (other than cocaine or methamphetamine dependence) or comorbidities known to impact neuropsychological functioning. Six articles were coded and analyzed for the current study.

Data Synthesis
Cocaine studies showed a medium statistically significant effect size (g = 0.370, p = 0.020), while methamphetamine did not (g = 0.198, p = 0.172). There was no heterogeneity in effect sizes for both drugs. Subgroup analysis found no significant difference between the two drugs on the PASAT (Q-between = 0.646, p = 0.421).

Conclusions
In contrast to methamphetamine, cocaine is associated with poorer performance on PASAT. This is in line with previous studies that found that cocaine had more significant impact on EF than methamphetamine. Given the preliminary nature of this meta-analysis and the small number of studies on the topic, future primary studies should directly contrast how these two drugs impact EF.
A-27 Stroop Color-Word Interference Test in Alcohol Use Disorder
Authors: Holt A , Hauson A , Ujj P , Reszegi K , Nemanim N , Flora-tostado C , Connors E 
Published: August 2019

Abstract

Objective
Poor inhibitory control is a characteristic of Alcohol Use Disorder (AUD) that might be associated with worse treatment outcomes because of its contribution to the likelihood of relapse. One valid and efficient tool to examine inhibitory control is the Stroop Color-Word Interference Test (Stroop inhibition). The purpose of this meta-analysis was to examine the consistency of findings on the Stroop inhibition subtest and its relationship to length of use and duration of abstinence in AUD.

Data Selection
Three researchers independently searched nine databases (e.g., PsycINFO, Pubmed, ProceedingsFirst), extracted required data, and calculated effect sizes. Inclusion criteria identified studies that had (a) compared participants with AUD to healthy controls and (b) matched groups on either age, education, or IQ. Studies were excluded if participants were reported to have Axis I diagnoses (other than AUD) or comorbidities known to impact neuropsychological functioning. Twelve articles were coded and analyzed for the current study.

Data Synthesis
Studies comparing AUD to controls showed a medium statistically significant effect size (g = 0.355, p < 0.001) with no heterogeneity (I2 = 0). Length of use and duration of abstinence did not predict effect sizes.

Conclusions
The Stroop inhibition measure distinguishes between AUD participants and controls. Given the robustness of this finding, the lack of heterogeneity among studies, and the extensive past use of the Stroop to measure inhibitory control; this test should be considered when examining AUD patients. This is especially important when patients exhibit poor inhibition in daily functioning.
A-31 Trails-X Trail-Level Performance Using the Profile Variability Index
Authors: Greene J , Messer M , Hartman D , Reynolds C 
Published: August 2019

Abstract

Objective
The Trails-X is a new type of trail-making test that emphasizes executive function and does not require either literacy or numeracy. The purpose of this study was to examine performance variability across trails.

Method
Participants were the Trails-X standardization sample and individuals with traumatic brain injury (TBI), learning disabilities (LD), intellectual disabilities (ID), attention-deficit hyperactivity disorder (ADHD), and dementia. Trail-level performance was assessed via the mean Matrix, Connected Circles, and Time to Discontinue scores across trails. The Profile Variability Index (PVI) was calculated (Plake, Reynolds, & Gutkin, 1981) and clinical groups and standardization samples were compared via a one-way ANOVA.

Results
Across all trails, the mean Matrix score was 6 (possible range = 1-12) for the standardization sample and as low as 3 for the dementia and ID samples. The mean Connected Circles score was 16 (possible range = 0-22) and as low as 12 for the dementia sample. The mean Time to Discontinue score was 39 seconds (possible range = 1-75) and as high as 55 for the dementia sample. There was a statistically significant difference on the PVI score (F(5,845) = 6.921, p = .000). The dementia (M = 4.77) and ID (M = 5.11) samples had significantly lower (p < .05) PVI scores than the other samples, which were not significantly different from each other.

Conclusions
The dementia and ID samples were characterized by consistently low performance while the other samples were characterized by moderate amounts of variability, indicating that some variability across trails should be expected within less impaired individuals.
A-33 Visuospatial Working Memory Performance and Adult ADHD Symptom Severity
Authors: LeRoy A , Young C , Cooke H , Jacova Chenoweth C 
Published: August 2019

Abstract

Objective
Working memory performance among adults with Attention-Deficit/Hyperactivity Disorder (ADHD) demonstrates variable results across literature. This investigation evaluated performance on a visuospatial working memory task relative to scores on measures of ADHD subtype and severity.

Method
A community sample aged 18 to 77 (n = 31; n men = 15) completed neuropsychological testing and measures of ADHD. The sample was predominantly White (64%; n = 20) and highly educated (Myears = 15.6). Participants were eligible if they were 18 or older, regardless of ADHD symptoms/diagnosis, and excluded if they had neuromedical/neuropsychiatric disorders. Spatial Addition (SA) from the Wechsler Memory Scale (WMS-IV) assessed working memory; the Adult ADHD Clinical Diagnostic Scale (ACDS) and Adult ADHD Investigator Symptom Rating Scale (AISRS) assessed ADHD subtype and burden.

Results
AISRS scores did not explain any variance in SA scores, R2 = 00, p = .970 (β = -.020, p = .970). A one-way between subjects ANOVA demonstrated no significant differences on SA scores between groupings based on ACDS: ADHD (n = 9, M = 13, SD = 4.12), and non-ADHD (n = 20, M = 13.95, SD = 5.27), (F(3,25) = .592, p = .626); ADHD (Inattentive (n = 2, M = 14.4, SD = .707); Hyperactive (n = 1, M = 18.00); Combined (n = 6, M = 11.7, SD = 4.8)). Adjustment for age and education did not change these findings.

Conclusions
Results failed to indicate any association between visuospatial working memory scores and ADHD symptoms but a larger, diversified sample is necessary to corroborate this null finding.
A-37 Effects of Atypical Language Representation in Populations Suffering From Intractable Epilepsy
Authors: Nagele M , Bailey K , Kolessar M , O'Neill T , Yetkin Z 
Published: August 2019

Abstract

Objective
Atypical language laterality, secondary to refractory epilepsy, presents complications to surgical planning/cognitive outcomes. Extant research shows the non-dominant hemisphere reallocates neural resources for language compensation in response to left-sided lesions (resulting in decreased visuoperceptual/visual memory). The present study examined relationships between 1) lesion location and atypical language organization and 2) lesion location/language laterality on performance on memory (California Verbal Memory Test 2nd-edition (CVLT; Delayed Recall), and visuoperceptual (Rey-Osterrieth Complex Figure Test, ROCFT; Copy) tests in relation to lesion location in a sample of patients with intractable epilepsy.

Method
Retrospective data was compiled on patients with refractory epilepsy undergoing interdisciplinary pre-surgical workup (N = 101), mean age of 37.2 (SD = 11.9) and mean education of 12.3 (SD = 3.7). The sample was then stratified by non-lesional (n = 48), left (n = 26), right (n = 21) or bilateral (n = 6) mesial temporal sclerosis (MTL); and, language laterality was confirmed by neuroradiologists via functional Magnetic Resonance Imaging (fMRI) scans.

Results
Analyses showed patients with left MTS were more likely to have atypical language organization, X2 (1, N = 47) = 6.6, p = .01. Moreover, significant differences on T-scores for CVLT, F (3,15) = 3.81, p = .04, 95% Cl [-1.73, -.08] and ROCFT, F(4,28) = 2.85, p = .046 95% Cl [31.62, 46.17] were found between groups stratified by lesion location/language laterality, respectively.

Conclusions
Organization of language in epileptic populations presents atypically in conjunction with left-sided lesions. Additionally, cognitive processes such as verbal memory and visuoperceptual abilities suffer based on lesion presence/location and language laterality in this fMRI confirmed sample.
A-40 Utility of the Spanish Auditory and Visual Naming Test in identifying word- finding difficulty in Spanish-speaking adults with Epilepsy
Authors: Bortnik K 
Published: August 2019

Abstract

Objective
Although visual naming (VN) and complementary auditory naming (AN) have proven clinically useful in the pre-surgical work-up of adults with epilepsy, they are available only in English, which compromises assessment for many native Spanish-speakers. VN is typically assessed with the Pontón-Satz Boston Naming Test (PS-BNT), yet this measure is of questionable validity due to vocabulary confounds and inclusion of culturally unfamiliar items. This pilot study examines the utility of the Spanish Auditory and Visual Naming Test (S-AVNT) in a small sample of native Spanish speakers with epilepsy.

Method
20 adult, native Spanish-speaking patients with unilateral temporal lobe epilepsy (TLE; 12 left, 8 right) were recruited (Mage = 41 years, SD = 10.1; Meducation = 12 years, SD = 2.8). Performance measures included: Accuracy (% correct), response time (RT), and tip-of-tongue errors (TOT; i.e., correct responses > 2 seconds or correct following a phonemic cue).

Results
Results: S-AVNT accuracy was high across RTLE and LTLE groups (93-97%) compared to the PS-BNT (59%; p = .000). There were no significant group-level differences, however within-group analyses revealed that VN was superior to AN across all performance measures (all ps < .01).

Conclusions
These preliminary findings represent the first step towards valid, culturally appropriate AN and VN tests for use with native Spanish speakers. The significant within-subjects differences are promising, particularly with respect to RT (i.e., slower auditory RT compared with visual RT) and TOT errors (i.e., auditory TOT > visual TOT), and may provide a more complete picture of naming ability than accuracy scores alone. Funded by NAN Clinical Research Grant.
A-43 Factorial Relationships Among Copy and Memory Trials of the Benton Visual Retention Test
Authors: Gukasyan M , Bhowmick c , Moses J 
Published: August 2019

Abstract

Objective
We investigated the factorial relationships among categorical error groups on the Benton Visual Retention Test (BVRT) copy and memory trials.

Methods
A sample of 523 ambulatory American Veteran patients who presented for clinical evaluation with a wide variety of mixed neuropsychiatric diagnoses and general medical diagnoses were studied. There were no demographic or diagnostic exclusion criteria.

Results
Frequency summary scores for the six types of BVRT errors (omission, misplacement, size, distortion, perseveration, and rotation errors) were factored jointly by means of principal component analysis. Omission, misplacement, and size errors grouped factorially across copy and memory domains by error type. Results showed the factorial relationships are primarily defined by the type of error. Omission, size, and misplacement errors were grouped together regardless of whether they occurred on copy or memory trials. Rotation, distortion, and perseveration errors were factorially grouped on both the copy and memory trials, but the groupings of these similar error groups formed independent factors for the copy and memory trials. The copy error factor explained the most variance and the memory error factor o explained the least variance.

Conclusions
Omission, size, and misplacement errors on the BVRT copy and memory trials appear to be due to similar encoding process errors. Distortion, rotation, and perseveration errors on the BVRT copy and memory trials are related to each other within each trial type but different cognitive processes account for errors of this kind on the copy and memory trials.
A-46 Impairments in Memory for “Who”, “When”, and “Where” are Detectable in Middle-Aged Adults
Authors: Mustafa A , Beltran-Najera I , Gilbert P , Graves L , Holden H , Lopez F , Sumida C , Van etten E 
Published: August 2019

Abstract

Objective
We conducted a cross-sectional study to examine age-¬related differences in performance on a new test assessing memory for “who, when, and where” and associations among these elements. The test was designed to assess aspects of episodic memory by simulating an everyday experience of meeting a series of different people in different places across time.

Method
Healthy young (ages 18¬-25), middle-aged (ages 40-55), and older adults (ages 60+) were asked to remember a sequence of pictures of different faces paired with different places. After viewing the sequence, the participants were asked to pair each face with the correct place and put the face-place pairs in the correct sequence. Participants also completed a battery of standardized neuropsychological tests.

Results
Young adults remembered significantly more face-place pairs in the correct sequence than middle-aged (p < .05) and older adults (p < .05). There were no significant differences between middle-aged and older adults in the number of face-place pairs in correct sequence. Furthermore, young adults remembered significantly more face-place pairs irrespective of sequence than older adults (p < .05). There were no significant differences between young and middle-aged adults or between middle-aged and older adults in the number of correct face-place pairs irrespective of sequence.

Conclusions
Using a new test that incorporates aspects of episodic memory, we found evidence for age-related differences in test performance beginning in middle age. We found that performance on the test correlated with performance on standardized measures of verbal memory and executive functioning but not visual confrontation naming.
A-49 Visual Memory Errors and Intelligence: The Role of Verbal Mediation
Authors: Hakinson K , Moses J , RIvera J , Guerra A , Davis M , Greenman K 
Published: August 2019

Abstract

Objective
Examine the relationship of verbal mediation with visual memory errors and intelligence to understand the role of spoken language on other assessment measures.

Method
Assessment records were obtained from a Veteran Affairs clinic for veterans (n=100) with diverse neuropsychiatric conditions who completed the Wechsler Adult Intelligence Scale, third edition (WAIS-III), Multilingual Aphasia Examination (MAE), and Benton Visual Retention Test (BVRT). A Principal Component Analysis (PCA) was used to examine the interrelationship among these assessments. The components of spoken language, types of errors on the BVRT, and the four factors of the WAIS-III were factored using the PCA to identify common sources of variance.

Results
A principal component analysis revealed a six-factor model explaining 68.16% of the shared variance among the WAIS-III factors, MAE components, and BVRT Errors. Omission errors loaded with Processing Speed and Controlled Word Association. Distortions and size errors loaded with Perceptual Organization. Size errors also loaded with Verbal Comprehension and Visual Naming. Misplacements loaded with Working Memory and Sentence Repetition. Misplacements, perseverations, and omissions loaded with the Token Test (a measure associated with auditory comprehension). Rotation errors loaded with Perceptual Organization.

Conclusions
Results indicated significant shared variance between visual memory errors, spoken language, and intelligence factors. This suggests that spoken language is involved in the process of visual memory, and deficits in spoken language may result in increased errors on visual memory tasks. Therefore, treatment recommendations for visual memory difficulties should take into consideration verbal capabilities and intelligence factors to better individualize treatment.