bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing oxygen‐blocking properties of HfB2‐MoSi2‐SiC coating by CeO2 modification
Authors: Zhang Sheng , Ji Xiang , Chen Yuexing , Wang Peipei , Kiryukhantsev‐Korneev Philipp V. , Levashov Evgeny A. , Shi Ji , Ren Xuanru , Kang Xueqin , Zhang Baojing , Zhang Ping , Xu Leihua 
Published: November 2024

AbstractTo alleviate the destructive alteration of the glass layer surface caused by gas evolution during the oxygen‐blocking process of the HfB2‐MoSi2‐SiC coating, CeO2 was incorporated to modify HfB2‐MoSi2‐SiC coating, and the anti‐oxidation mechanism at 1700°C in air was investigated. Compared with the unmodified HfB2‐MoSi2‐SiC coating, the addition of the refractory CeO2 to the Hf‐B‐Si‐O system leads to the formation of a stable Hf‐Ce‐B‐Si‐O complex phase glass, which substantially enhances the viscosity, stability, and self‐healing sealing properties of the glass layer. The introduction of 0.75 vol.% CeO2 significantly lowers the oxidative activity of the HfB2‐MoSi2‐SiC coating, boosting its average protective efficiency to 99.96% and reducing the maximal oxygen permeability by 43.48%, thus exhibiting superior oxygen‐blocking performance. However, excessive addition of CeO2 leads to an overabundance of oxygen release through its distinctive oxygen vacancy mechanism, which accelerates the formation of Hf‐oxides, resulting in excessive viscosity on the coating surface and leaving oxidation defects unrepaired.
Implementing the MIRROR‐TCM Randomised Control Trial During the COVID‐19 Pandemic: A Mixed‐Methods Evaluation
Authors: McHugh Molly , Hirschman Karen B. , Toles Mark P. , Ahrens Monica , Morgan Brianna , Osokpo Onome , Shaid Elizabeth C. , McCauley Kathleen , Hanlon Alexandra L. , Pauly Mark V. , Naylor Mary D. 
Published: November 2024

ABSTRACTAimTo evaluate the implementation of the Transitional Care Model (TCM), an evidence‐based, advanced practice registered nurse‐led multi‐component intervention, as part of a randomised controlled trial during the first year of the COVID‐19 pandemic.DesignParallel convergent mixed‐methods approach.MethodsData for this study were collected between June 2020 and February 2021. Data from 78 patients who received the intervention and 68 recorded meetings with system leaders and clinical teams were analysed using descriptive statistics, directed content analysis, and joint display.ResultsFidelity to delivery of elements of the TCM components was variable, with the Hospital‐to‐Home visit elements having the widest range (14.3%–100%) and Maintaining Relationships elements having the highest range (97.3%–98.6%). There were 27 identified challenges and 15 strategies for implementing the TCM with fidelity during the pandemic.ConclusionThe COVID‐19 pandemic impacted all aspects of the delivery of the TCM across all sites. This historical event highlighted the need for services and support for patients and caregivers transitioning from the hospital to home.Implications for Nursing and Patient CareEvidence‐based solutions are needed to enhance healthcare delivery and patient outcomes. Findings will guide nurses in implementing proven transitional care interventions.ImpactFindings will inform the implementation and scaling of transitional care and other evidence‐based interventions across diverse healthcare settings.Reporting MethodGRAMMS reporting guidelines.Patient or Public ContributionNo patient or public contribution.Trial RegistrationClinicalTrials.gov identifier: NCT04212962. https://www.clinicaltrials.gov/study/NCT04212962?titles=NCT04212962&rank=1
Health‐Related Quality of Life in Women With Metastatic Breast Cancer: An Integrative Review
Authors: Zhan Yan , Feder Shelli L. , Lustberg Maryam , Batten Janene , Knobf M. Tish 
Published: November 2024

ABSTRACTAimTo examine current evidence on health‐related quality of life and its associated factors in women with metastatic breast cancer over the past 10 years.DesignAn integrative review.Data SourcesWe conducted a comprehensive search across five databases: CINAHL, EMBASE, MEDLINE, PsycINFO, and Web of Science, for studies published between January 2013 and June 2023.Review MethodsFollowing the integrative review guideline, we screened full‐text papers based on the inclusion and exclusion criteria. The quality of the studies was assessed using the Joanna Briggs Institute's appraisal checklist, and the data were extracted and synthesised.ResultsOf 7316 articles, 25 studies met the inclusion criteria. Most of the participants were non‐Hispanic white women from the United States or Europe. Various instruments were used to assess health‐related quality of life. The key factors included sociodemographic and clinical characteristics, physical symptoms and function, disease stability and progression, and psychological attributes. Although targeted agents and immunotherapy are common therapies today, data on their side effects and health‐related quality of life remain limited. Literature gaps included a lack of racially diverse samples, an absence of data on protective factors, and limited insights into symptom experience with novel therapies.ConclusionsPhysical and psychological symptoms were still the major influencing factors. Clinicians should prioritise symptom management in women. Future research is needed to increase racial diversity in the study and explore novel agents related to symptoms and protective factors that may improve health‐related quality of life.ImpactWomen with metastatic breast cancer experience compromised health‐related quality of life. Understanding which factors influence their quality of life, particularly those on novel therapies is critical for providing high‐quality, individualised care and developing targeted interventions to improve their well‐being.Reporting MethodPRISMA.No Patient or Public ContributionThis integrative review does not need patient or public contribution.
Patients' Ability to Self‐Manage Their Surgical Wound to Prevent Wound Complications: A Cross‐Sectional Study
Authors: Groenen Hannah , Bontekoning Nathan , Van Dieren Susan , Orsini Ricardo G. , Boermeester Marja A. , Tobiano Georgia , Eskes Anne M. 
Published: November 2024

ABSTRACTAimsTo provide insights into postdischarge patients' experiences and preferences regarding surgical wound care education at discharge in the Netherlands.BackgroundPatient involvement in wound care practices postdischarge is beneficial for the prevention of surgical site infections and has become an essential component in reducing the burden on healthcare systems. Surgical wound care discharge education is crucial to achieve this.MethodsA cross‐sectional survey was conducted using the 18‐item Surgical Wounds And Patient Participation Questionnaire on patients who underwent surgery between January and May 2022. The survey was administered 2 weeks postoperatively.ResultsIn total, 213 patients completed the survey. Most patients preferred verbal instructions about their surgical wound care (n = 146; 84.9%) at the time of discharge, with 52.3% indicating a preference for multiple forms of information. Approximately three‐quarters of patients (n = 99; 76.7%) responded that they were able to successfully take care of their wounds at home and 16.3% indicated wound self‐care inability.ConclusionOur study highlighted patients' preferences for verbal instructions about their surgical wound care at the time of discharge. Notably, half of the patients expressed a desire for multiple forms of information. Furthermore, we identified gaps in the information provided to patients, indicating areas for improvement in discharge communication.ImplicationsThe identified gaps in surgical wound care discharge education offer opportunities to enhance in‐hospital education by aligning it more closely with patient preferences and providing education of topics often missed. This could ultimately improve their ability to self‐manage their surgical wound at home. Future research should delve deeper into understanding the factors influencing patients' ability to self‐manage their wounds.Impact

Despite the acknowledged importance of patient education on surgical wound care, there is limited literature regarding patients' experiences and preferences in this area.

The findings of this study highlight patients' preferences for verbal instructions and reveal gaps in the information provided to patients about surgical wound care at the time of discharge.

The identified gaps in information provided to surgical patients offer opportunities to enhance in‐hospital education by healthcare professionals.

Reporting MethodWe adhered to the STROBE guideline.Patient or Public ContributionNo patient or public contribution.
Obesity, aldosterone excess, and mineralocorticoid receptor activation: Parallel or intersected circumstances?
Authors: Puzantian Houry , Townsend Raymond , Bansal Shweta 
Published: November 2024

AbstractThe obesity pandemic, with its associated comorbidities of hypertension and diabetes, constitutes a global public health issue. Importantly, there is an increasing prevalence of aldosterone excess related to obesity and resultant poor health outcomes. Nevertheless, the association between aldosterone and obesity still needs to be clarified. In this review, the authors discuss the role of white adipose tissue in linking obesity, aldosterone excess, and hypertension. The consequences of aldosterone excess in obesity are presented as genomic, non‐genomic, and non‐epithelial effects. Moreover, the authors emphasize the value of interference with aldosterone pathophysiology (as with mineralocorticoid antagonists) in obesity, thus reducing the adverse clinical impact of aldosterone in myocardial infarction, heart failure, kidney dysfunction, and associated mortality.
HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS‐induced acute kidney injury
Authors: Huang Lili , Wu Yuanyuan , Sai Wenli , Wang Yanan , Feng Guijuan , Lu Yuqing , Chen Fei , Huang Xinzhong , Zhao Hongsheng , Gu Zhifeng , Yang Bin 
Published: November 2024

AbstractSepsis‐associated acute kidney injury (AKI) has high morbidity and mortality, but without cause‐specific treatment. Erythropoietin derived Helix B surface peptide (HBSP) alleviates AKI, whereas its underlying mechanisms remain to be further explored. Here, the effects of HBSP on pyroptosis, apoptosis, macrophage polarization and repair were investigated in lipopolysaccharide (LPS)‐induced AKI mouse model and cultured kidney epithelial cells. Systemic inflammation, compromised renal function and histology were demonstrated in LPS‐treated mice, with upregulated pyroptotic and apoptotic key proteins in the kidneys including GSDMD‐N, cleaved IL‐1β, IL‐18 and caspase‐3. These proteins were localized in tubular areas and colocalized with aquaporin‐1 (AQP1), with increased F4/80+ M1 macrophages. However, HBSP mitigated pyroptosis, apoptosis and inflammation, and promoted macrophage M2 polarization. In addition, HMGB1 and erythropoietin receptor (EPOR) were increased by LPS and decreased by HBSP, both of which were positively correlated with pyroptotic and apoptotic proteins. Moreover, HBSP reduced TNF‐α and IL‐6 mRNA levels, as well as pyroptosis and apoptosis in LPS‐stimulated TCMK‐1 cells. In conclusion, HBSP inhibited tubular pyroptosis and apoptosis, EPOR expression, promoted macrophage M2 polarization, and protected against LPS‐induced AKI. These findings provide new mechanistic insights into the renoprotection of HBSP, and facilitate its potential for clinical applications and therapeutic strategies in sepsis‐associated AKI.
‘You Know, This Conference Has No Legitimacy’: Eurosceptic Contestation of the Conference on the Future of Europe
Authors: Kotýnek Krotký Jan 
Published: November 2024

AbstractAmid the escalating contestation of European integration, the European Union (EU) endeavours participatory innovations to bridge the gap between EU institutions and citizens whilst addressing the challenges posed by Eurosceptic actors. This article builds on empowering dissensus, arguing that Eurosceptic contestation might strengthen EU integration by making EU issues a matter of discussion in the European public sphere. It expands its application beyond policy contestation to polity contestation. The article examines the Eurosceptic discourse surrounding the Conference on the Future of Europe (CoFoE), a pioneering deliberative attempt to bring citizens closer to EU institutions. Employing thematic analysis of various documents produced by Eurosceptic political groups, the article reveals two predominant themes through which these groups challenged the legitimacy of the CoFoE: manipulative governance and lack of representativity. These themes closely align with academic assessments and reinforce the Eurosceptic narrative of an ‘elite cartel’ governing the EU.
A Geoeconomic Fix? European Industrial Policy on Semiconductors Amidst Global Competition
Authors: Ruck Jan 
Published: November 2024

AbstractThis article observes that state actors in the emerging geoeconomic order are increasingly intervening in value chains that are politically regarded as strategic, with the aim of anchoring production capacities in their own territory. Drawing on David Harvey's concept of the ‘spatial fix’ and modifying it for the geoeconomic constellation, the article describes this phenomenon as a ‘geoeconomic fix’. However, this geoeconomic fix can only be achieved in co‐operation with industrial actors that possess strategic capabilities and technological know‐how. In a case study of European semiconductor policy from 2012 to 2023, the contribution traces changes in European industrial policy. Using process tracing, the article analyses key documents and statements from European Union (EU) institutions and industry actors. The results demonstrate that the geoeconomization of European semiconductor policy is accompanied by an increasing political focus on the spatial reorganization of the semiconductor value chain. The European semiconductor industry is driving this geoeconomization.
Retention of blue‐green cryptophyte organelles by Mesodinium rubrum and their effects on photophysiology and growth
Authors: Moeller Holly V. , L'Etoile‐Goga Amelie , Vincenzi Lucas , Norlin Andreas , Barbaglia Gina S. , Runte Gabriel C. , Kaare‐Rasmussen Jonatan T. , Johnson Matthew D. 
Published: November 2024

AbstractAs chloroplast‐stealing or “kleptoplastidic” lineages become more reliant on stolen machinery, they also tend to become more specialized on the prey from which they acquire this machinery. For example, the ciliate Mesodinium rubrum obtains > 95% of its carbon from photosynthesis, and specializes on plastids from the Teleaulax clade of cryptophytes. However, M. rubrum is sometimes observed in nature containing plastids from other cryptophyte species. Here, we report on substantial ingestion of the blue‐green cryptophyte Hemiselmis pacifica by M. rubrum, leading to organelle retention and transient increases in M. rubrum's growth rate. However, microscopy data suggest that H. pacifica organelles do not experience the same rearrangement and integration as Teleaulax amphioxeia's. We measured M. rubrum's functional response, quantified the magnitude and duration of growth benefits, and estimated kleptoplastid photosynthetic rates. Our results suggest that a lack of discrimination between H. pacifica and the preferred prey T. amphioxeia (perhaps due to similarities in cryptophyte size and swimming behavior) may result in H. pacifica ingestion Thus, while blue‐green cryptophytes may represent a negligible prey source in natural environments, they may help M. rubrum survive when Teleaulax are unavailable. Furthermore, these results represent a useful tool for manipulating M. rubrum's cell biology and photophysiology.
Morphometric synthesis of Pollimyrus (Teleostei, Mormyridae) with the description of four new species
Authors: Dierickx Katrien , Wamuini Lunkayilakio Soleil , Bills Roger , Vreven Emmanuel 
Published: November 2024

AbstractMormyridae, a species‐rich family endemic to Africa, remains taxonomically understudied. This has been the case for the genus Pollimyrus Taverne, 1971, which hinders further understanding of the distribution, ecology, and conservation of its species. Therefore, an in‐depth morphometric comparison of all currently valid species is carried out using most of the available type specimens. Species delineations were re‐evaluated, and four species new to science described: Pollimyrus ibalazambai sp. nov. (the Luki River, the Democratic Republic of the Congo), Pollimyrus krameri sp. nov. (the Lugenda River, Mozambique), Pollimyrus vanneeri sp. nov. (the Kouilou‐Niari River, the Republic of the Congo), and Pollimyrus weyli sp. nov. (the Buzi River, Mozambique). In this study, Pollimyrus guttatus is confirmed to belong to Pollimyrus, whereas Pollimyrus eburneensis and Cyphomyrus plagiostoma seem more similar to species allocated to other genera. No or only little morphological differences were found between the type series of several species, which could indicate the need for synonymization of these species (Pollimyrus cuandoensis with Pollimyrus marianne and Pollimyrus nigripinnis with Pollimyrus pulverulentus). As such 20 species are currently morphologically identifiable in the genus Pollimyrus. The present study highlights the critical need for further synthetic efforts and new collecting efforts across Africa for this and other Mormyridae genera.
Influence of Lifestyles on Polyp Burden and Cancer Development in Hereditary Colorectal Cancer Syndromes
Authors: Hyun Hye Kyung , Park Ji Soo , Park Jihye , Park Soo Jung , Park Jae Jun , Cheon Jae Hee , Kim Tae Il 
Published: November 2024

ABSTRACTBackgroundWhether the progression of precursor lesions or the occurrence of cancer is influenced by lifestyle factors in carriers of genetic mutations has not been fully investigated, especially in Asian patients of hereditary colorectal cancer (CRC) syndrome.MethodsPatients at a high risk of hereditary CRC were included. For polyposis CRC syndromes, colorectal polyp burden was measured using at least 60 images per colonoscopy in each patient and classified into five stages using the International Society for Gastrointestinal Hereditary Tumours staging system according to the polyp number and size. Increase in tumor burden stage for polyposis CRC syndrome and the occurrence of CRC or any cancer for Lynch syndrome were analyzed according to lifestyle factors.ResultsNinety‐six patients with suspected hereditary polyposis CRC syndrome and 106 patients with Lynch syndrome were recruited. For polyposis CRC syndromes, multivariate analysis showed that exposure to smoking and > 100 polyps independently predicted a high risk of increased polyp burden (p = 0.008 and p = 0.012, respectively). Significant genetic mutations or phenotype of polyposis syndromes were significantly associated with an increased polyp burden. For Lynch syndrome, smokers showed to be diagnosed with CRC in younger age than never‐smokers (42.2 years vs. 49.0 years; p = 0.021), and heavy drinkers had high risk for occurrence of CRC (HR, 2.381, 95% CI, 1.338–4.236; p = 0.003) and any cancer (HR, 2.254; 95% CI, 1.334–3.806; p = 0.002).ConclusionsThe lifestyle factors (smoking and alcohol consumption) were associated with increasing precursor lesions and occurrence of cancer in patients with hereditary CRC syndrome. Lifestyle modifications may reduce the risk of hereditary CRC in carriers.
Adults With Intellectual Disabilities and Incontinence: Assessment and Toileting Issues
Authors: Finlayson Janet , Skelton Dawn A. , Ord Paul , Roche Fiona , Marshall Audrey , Butcher John , Gore Nick 
Published: November 2024

ABSTRACTBackgroundUrinary and bowel incontinence are more common in adults with intellectual disability (ID), compared to the general population. Little is known about their incontinence experiences and toileting issues. The aim was to learn about their experiences and toileting issues.MethodIncontinence and toileting issues assessment was conducted with a community‐based sample of 22 adults with ID and urinary incontinence, with or without bowel incontinence. Assessment included the IPSS, ICIQ‐UI, and POTI checklists; bladder scans; and urine sample screening for presence of a urinary tract infection.ResultsThe majority (19 adults, 86%) developed urinary incontinence during adulthood. Seven adults (32%) also experienced bowel incontinence, and constipation was the most commonly reported health condition (13 adults, 59%), other than urinary incontinence. Fifty per cent (11 adults) had been treated for a urinary tract infection within the previous 12 months.ConclusionThere is an urgent need to develop accessible and reliable incontinence assessment materials with and for adults with ID and their supporters. These assessments should pay close attention to health conditions that can cause incontinence in this group and factors associated with incontinence which are more commonly experienced by adults with ID. These factors are potentially modifiable.
Prediction of respiratory failure and prolonged mechanical ventilation in Guillain‐Barré syndrome: A prospective cohort study in Bangladesh
Authors: Papri Nowshin , Doets Alex Y. , Luijten Linda , Mohammad Quazi D. , Endtz Hubert P. , Lingsma Hester F. , Jacobs Bart C. , Islam Zhahirul 
Published: November 2024

AbstractBackground and AimsThe aim of this study is to validate and perform a region‐specific adjustment of the Erasmus GBS Respiratory Insufficiency Score (EGRIS) and identify potential predictors of prolonged mechanical ventilation (PMV) among Guillain‐Barré syndrome (GBS) patients from Bangladesh.MethodsWe enrolled GBS patients from four prospective observational cohort studies conducted in Bangladesh. Accuracy of EGRIS to predict the requirement of MV in <7 days of study entry was evaluated. Model performance was assessed by discrimination (ability of the model to differentiate between patients who needed MV or not) and calibration (accuracy of absolute risk estimates). PMV was defined as duration of MV >14 days. Potential predictors for PMV were evaluated by Cox regression.ResultsA total of 594 GBS patients aged ≥6 years old were enrolled; of whom 541 patients had complete EGRIS data prior to MV and were included in validation analysis. EGRIS correctly distinguished between patients requiring MV or not in 81% pairs (AUC = 0.81). EGRIS overestimated the probability of MV than the observed probability (41% vs. 20%) which was resolved by updating of the model intercept. Inability to flex hip at day 7 of start of MV was the strongest predictor for PMV with predicted probabilities of 82%.InterpretationEGRIS accurately predicts the need for MV in GBS patients from Bangladesh. This study developed a region‐specific version of EGRIS and identified predictors of PMV. These findings can assist clinicians to identify patients at high risk of developing respiratory failure and requiring PMV to ensure timely intubation and tracheostomy of the patients in low resource settings.