bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Dendrite‐Free Mn2+/Zn2+ Hybrid Battery with 2.3 V Voltage Window and 11000‐Cycle Lifespan
Authors: Li Ming , He Qiu , Li Zilan , Li Qi , Zhang Yuxin , Meng Jiashen , Liu Xiong , Li Shidong , Wu Buke , Chen Lineng , Liu Ziang , Luo Wen , Han Chunhua , Mai Liqiang 
Published: June 2019

AbstractWith the increasing energy crisis and environmental pollution, rechargeable aqueous Zn‐based batteries (AZBs) are receiving unprecedented attention due to their list of merits, such as low cost, high safety, and nontoxicity. However, the limited voltage window, Zn dendrites, and relatively low specific capacity are still great challenges. In this work, a new reaction mechanism of reversible Mn2+ ion oxidation deposition is introduced to AZBs. The assembled Mn2+/Zn2+ hybrid battery (Mn2+/Zn2+ HB) based on a hybrid storage mechanism including Mn2+ ion deposition, Zn2+ ion insertion, and conversion reaction of MnO2 can achieve an ultrawide voltage window (0–2.3 V) and high capacity (0.96 mAh cm−2). Furthermore, the carbon nanotubes coated Zn anode is proved to effectively inhibit Zn dendrites and control side reaction, hence exhibiting an ultrastable cycling (33 times longer than bare Zn foil) without obvious polarization. Benefiting from the optimal Zn anode and highly reversible Mn2+/Zn2+ hybrid storage mechanism, the Mn2+/Zn2+ HB shows an excellent cycling performance over 11 000 cycles with a 100% capacity retention. To the best of the authors' knowledge, it is the highest reported cycling performance and wide voltage window for AZBs with mild electrolyte, which may inspire a great insight into designing high‐performance aqueous batteries.
Schlauchwehre an französischen Wasserstraßen
Authors: Lechtenberg Jan‐Willem , Tinnemann Peter 
Published: June 2019

AbstractDie Wasser‐ und Schifffahrtsverwaltung Frankreichs betreibt mehr als 500 Wehranlagen. Im Zuge der Modernisierung der Wasserstraßen erfolgte 2010 die Ausschreibung für den Ersatz und Rückbau von 29 manuell betriebenen Nadelwehren sowie deren Betrieb über einen Zeitraum von 30 Jahren. Das Barrages Aisne Meuse wird als PPP‐Projekt ausgeschrieben. Der Zuschlag wird Anfang 2013 an das Konsortium BAMEO vergeben. Die Planung sieht vor, alle 29 manuell betriebenen Nadelwehre durch Schlauchwehranlagen zu ersetzen. Damit werden bei diesem Projekt erstmalig Schlauchwehre als technische Lösung für ein zusammenhängendes Infrastrukturprojekt angewendet. Floecksmühle Energietechnik GmbH erhält den Auftrag für die Planung und Lieferung der Schlauchwehranlagen und der dazugehörigen technischen Ausrüstung. Die Gesamtkosten für Planung, Bau sowie Wartung und Betrieb betragen 312 Mio. Euro. Die Projektdauer von 2013–2020 beinhaltet lediglich vier Jahre Bauzeit. Das Design der Schlauchwehranlagen und alle Prozesse werden daher in hohem Maße standardisiert. Darüber hinaus bieten Schlauchwehranlagen den Vorteil eines transport‐ und montagefreundlichen Systems mit kurzen Montagezeiten. Durch die erfolgreiche Umsetzung dieser Planungsgrundsätze und durch die effizient gestalteten Montageprozesse sind die Bauarbeiten im Januar 2019 an allen 29 Wehranlagen abgeschlossen und die ersten 20 Anlagen in Betrieb.
Wiederanbindung des historischen Hafens Bad Karlshafen an die Weser
Authors: Helfers Björn 
Published: June 2019

AbstractBad Karlshafen an der Nordspitze Hessens ist der geplante Traum. Der Gründer Landgraf Carl ließ das sumpfige Gebiet an der Mündung der Diemel in die Weser 1699 trockenlegen, um dort eine Barockstadt vom Reißbrett rund um ein Hafenbecken anzulegen. Das Hafenbecken inmitten der neuen Stadt wiederum sollte – ganz im Denken der Epoche – den Besatzungen der einfahrenden Schiffe ein prachtvoller Hinweis auf den Herrscher sein. Indem er solches mit den modernsten Techniken der Zeit erschaffen ließ, zeigte der Landgraf, dass es ihm sogar gelang, die Natur zu beherrschen und das Landschaftsbild regelrecht zu inszenieren. Die historische Schleuse zur Weser hin versieht ihren Dienst schon lange nicht mehr und die Brücke über die einstige Hafeneinfahrt wurde zum befestigten Straßendamm, der das Becken für Schiffe von der Zufahrt zur Weser abriegelt. Dies wurde durch die Wiederanbindung des Hafens Bad Karlshafen an die Weser korrigiert und der Hafen damit wieder zur Weser hin geöffnet.
LncRNA DGCR5 regulates the non‐small cell lung cancer cell growth, migration, and invasion through regulating miR‐211‐5p/EPHB6 axis
Authors: Kang Mafei , Shi Jieqiong , Li Bihui , Luo Meiqing , Xu Shengyuan , Liu Xiuli 
Published: June 2019

AbstractNon‐small cell lung cancer (NSCLC) accounts for about 80% of lung cancers worldwide. In recent years, importance of noncoding RNAs including long noncoding RNA and microRNA in regulating tumor progression has been appreciated. Abnormally expression of DiGeorge syndrome critical region gene 5 (DGCR5) was found in multiple human cancers but its function in NSCLC is largely unknown. Reverse transcription quantitative polymerase chain reaction (RT‐qPCR) was conducted to explore DGCR5 expression level in NSCLC. Bioinformatic analyses were conducted to explore the targets of DGCR5. Cell counting kit‐8 assay, wound‐healing assay, and transwell invasion assay were performed to analyze functions of DGCR5. RT‐qPCR revealed that DGCR5 expression in NSCLC cells was significantly lower than in normal cell. DGCR5 overexpression suppresses NSCLC cell growth, migration, and invasion. Online algorithms found EPH receptor B6 (EPHB6) and DGCR5 contains same miR‐211‐5p binding region. The predicted connections were further validated by luciferase activity reporter assay. Recue experiments showed DGCR5 regulates NSCLC cell behaviors via targeting miR‐211‐5p/EPHB6. These findings collectively identified DGCR5/miR‐211‐5p/EPHB6 triple axis in NSCLC, which may novel understanding regarding the tumorigenesis of NSCLC.
Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene
Authors: Hino Hitoshi , Shiomi Akio , Kusuhara Masatoshi , Kagawa Hiroyasu , Yamakawa Yushi , Hatakeyama Keiichi , Kawabata Takanori , Oishi Takuma , Urakami Kenichi , Nagashima Takeshi , Kinugasa Yusuke , Yamaguchi Ken 
Published: June 2019

AbstractHere, we investigated the clinicopathological and mutation profiles of colorectal cancer (CRC) with POLE mutations. Whole‐exome sequencing was performed in 910 surgically resected primary CRCs. Tumors exceeding 500 counts of nonsynonymous single nucleotide variants (SNVs) were classified as hypermutators, whereas the remaining were classified as nonhypermutators. The hypermutators were subdivided into 2 groups. CRCs harboring more than 20% C‐to‐A and less than 3% C‐to‐G transversions were classified as POLE category tumors, whereas the remaining were classified as common‐hypermutators. Gene expression profiling (GEP) analysis was performed in 892 (98.0%) tumors. Fifty‐seven (6.3%) and 10 (1.1%) tumors were classified common‐hypermutators and POLE category tumors, respectively. POLE category tumors harbored a significantly higher SNV count than common‐hypermutators, and all POLE category tumors were associated with exonuclease domain mutations, such as P286R, F367C, V411L, and S297Y, in the POLE gene. Patients with POLE category tumors were significantly younger than those with nonhypermutators and common‐hypermutators. All POLE mutations in the early‐onset (age of onset ≤50 years old) POLE category (7 tumors) were P286R mutations. GEP analysis revealed that PD‐L1 and PD‐1 gene expression levels were significantly increased in both common‐hypermutators and POLE category tumors compared with those in nonhypermutators. CD8A expression was significantly upregulated in POLE category tumors compared with that in nonhypermutators. Thus, we concluded that CRCs with POLE proofreading deficiency had characteristics distinct from those of other CRCs. Analysis of POLE proofreading deficiency may be clinically significant for personalized management of CRCs.
Associations between environmental factors and serological Epstein‐Barr virus antibodies in patients with nasopharyngeal carcinoma in South China
Authors: Zhou Ting , Yang Da‐Wei , He Yong‐Qiao , Xue Wen‐Qiong , Liao Ying , Zheng Mei‐Qi , Jia Yi‐Jing , Yuan Lei‐Lei , Zhang Wen‐Li , Zeng Yi‐Xin , Jia Wei‐Hua 
Published: June 2019

AbstractEpstein‐Barr virus (EBV) reactivation, reflected by aberrantly increased levels of various serological antibodies, has been suggested to be an early indicator of nasopharyngeal carcinoma (NPC) onset and progression. We have previously suggested that certain lifestyle and dietary factors were associated with elevated serological levels of the antibody against various EBV antigens namely VCA, Zta, EBNA1, and oral EBV DNA loads among healthy population. It remains unclear whether these potential environmental factors would also influence EBV serological antibodies in NPC patients. We conducted an epidemiological study to evaluate the associations between such environmental factors and EBV antibody levels among 1701 NPC patients in South China. Pretreatment serums were collected and examined for VCA‐IgA and EA‐IgA by immunoenzymatic assays and antienzyme rate (AER) of EBV DNase‐specific neutralizing antibody. We found that consumption of Canton‐style herbal tea was significantly correlated with increased serological antibody levels of VCA‐IgA and EA‐IgA, with adjusted ORs of 1.35 (95% CI: 1.03‐1.76) and 1.32 (95% CI: 1.01‐1.73), respectively, in the weekly intake frequency stratum, while not related to AER of EBV DNase‐specific neutralizing antibody. Smoking was found to be not only an apparent risk factor for higher antibody levels of AER in stage III‐IV patients (OR = 1.60, 95% CI: 1.11‐2.30), but also associated closely with NPC stage at diagnosis (OR = 2.17, 95% CI: 1.47‐3.22), with dose‐response effects. In conclusion, we found consumption of Canton‐style herbal tea and cigarette smoking were in positive associations with elevated EBV antibodies in NPC patients, which may be of public health significance for the primary prevention of EBV‐associated diseases especially NPC.
Mechanistic Study on the Selective Oxidation of Acrolein to Acrylic Acid: Identification of the Rate‐Limiting Step via Perdeuterated Acrolein
Authors: Knoche Stefan , Heid Maurice , Gora Niklas , Ohlig Dominik , Drochner Alfons , Hess Christian , Etzold Bastian , Vogel Herbert 
Published: June 2019

AbstractGas phase oxidation of acrolein to acrylic acid on hydrothermally prepared Mo/V/W mixed oxides was investigated by isotopic labeling of acrolein. In this context, perdeuterated acrolein was synthesized for the first time and subsequently used for mechanistic studies. A clear kinetic isotopic effect (KIE) is observed referring to the α‐hydrogen‐abstraction as the rate‐determining step in the selective acrolein oxidation. Furthermore, no change in the selectivity patterns is observed due to the perdeuteration, which confirms that the α‐hydrogen‐abstraction also acts as the rate‐limiting step in the total oxidation of acrolein. Based on these KIE studies combined with additional experiments including D2O‐SSITKA and temperature‐programmed desorption, a detailed reaction mechanism for acrolein oxidation is proposed.
Synthesis and X‐ray diffraction study of a chiral bis‐phosphahelicene palladium (II) complex
Authors: Sanogo Youssouf , Aillard Paul , Retailleau Pascal , Voituriez Arnaud , Marinetti Angela 
Published: June 2019

AbstractAs a complement to our previous studies on the development of a class of chiral phosphahelicenes, this article discloses the synthesis, spectroscopic, and structural characterizations of a new phosphahelicene transition metal complex. It demonstrates the ability of these hindered chiral ligands to coordinate Pd (II) in trans‐complexes Cl2Pd(L*)2. In the solid state, the complex adopts a C2‐symmetric arrangement with two ligands facing each other on the same face of the coordination plane. X‐Ray data highlight bending of the Pd (II) unit from the expected planar coordination geometry that might be due to a significant π‐π stacking effect between the central rings of two helical units.
Synthetic data method to incorporate external information into a current study
Authors: Gu Tian , Taylor Jeremy M. G. , Cheng Wenting , Mukherjee Bhramar 
Published: June 2019

AbstractWe consider the situation where there is a known regression model that can be used to predict an outcome, Y, from a set of predictor variables X. A new variable B is expected to enhance the prediction of Y. A dataset of size n containing Y,X and B is available, and the challenge is to build an improved model for Y|X,B that uses both the available individual level data and some summary information obtained from the known model for Y|X. We propose a synthetic data approach, which consists of creating m additional synthetic data observations, and then analyzing the combined dataset of size n + m to estimate the parameters of the Y|X,B model. This combined dataset of size n + m now has missing values of B for m of the observations, and is analyzed using methods that can handle missing data (e.g., multiple imputation). We present simulation studies and illustrate the method using data from the Prostate Cancer Prevention Trial. Though the synthetic data method is applicable to a general regression context, to provide some justification, we show in two special cases that the asymptotic variances of the parameter estimates in the Y|X,B model are identical to those from an alternative constrained maximum likelihood estimation approach. This correspondence in special cases and the method's broad applicability makes it appealing for use across diverse scenarios. The Canadian Journal of Statistics 47: 580–603; 2019 © 2019 Statistical Society of Canada
A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity
Authors: Warheit‐Niemi Helen I , Hult Elissa M , Moore Bethany B 
Published: June 2019

AbstractLung fibrosis is characterised by the accumulation of extracellular matrix within the lung and is secondary to both known and unknown aetiologies. This accumulation of scar tissue limits gas exchange causing respiratory insufficiency. The pathogenesis of lung fibrosis is poorly understood, but immunologic‐based treatments have been largely ineffective. Despite this, accumulating evidence suggests that innate immune cells and receptors play important modulatory roles in the initiation and propagation of the disease. Paradoxically, while innate immune signalling may be important for the pathogenesis of fibrosis, there is also evidence to suggest that innate immune function against pathogens may be impaired, leading to dysregulated and/or impaired host defence. This review summarises the evidence for this pathologic two‐way street, highlights new concepts of pathogenesis and recommends future directions for research emphasis.
Effects of ZnO Nanoparticles and Ethylenediamine‐N,N′‐Disuccinic Acid on Seed Germination of Four Different Plants
Authors: Doğaroğlu Zeynep Görkem , Eren Abdullah , Baran M. Fırat 
Published: June 2019

AbstractThe release of nanoparticles and biodegradable chelating agents into the environment may cause toxicological and ecotoxicological effects. The aim of this study is to determine the ecotoxic effects of zinc oxide (ZnO) nanoparticles and ethylenediamine disuccinic acid (EDDS) on most cultured four plants. The durum wheat, bread wheat, barley, and rye are exposed to 5 mL 10 mg L−1 ZnO nanoparticles and 10 mg L−1 EDDS in the seed germination stage. Results show that these different plant species have different responses to ZnO nanoparticles and EDDS. The germination percentage of bread wheat and rye decreases in the application of ZnO nanoparticles while the germination of durum wheat and barley increases as much as in radicle elongation and seedling vigor. While ZnO treatment causes a decrease in bread wheat and rye germinated rat in the range of 33–14.3%, respectively, there is no change in germination rate of these plants at EDDS treatment. In addition, EDDS treatment positively affects barley germination rate. In conclusion, it is clear that ZnO nanoparticles have more toxic effects on bread wheat and rye than EDDS, while barley is positively affected by ZnO nanoparticles and EDDS.
Utilization of rehabilitation services in patients with head and neck cancer in the United States: A SEER‐Medicare analysis
Authors: Wang Jennifer R. , Nurgalieva Zhannat , Fu Shuangshuang , Tam Samantha , Zhao Hui , Giordano Sharon H. , Hutcheson Katherine A. , Lewis Carol M. 
Published: June 2019

AbstractBackgroundHead and neck cancer (HNC) and its treatment lead to functional impairments. Rehabilitation by speech‐language pathology (SLP) and occupational/physical therapy (OT/PT) can decrease morbidity.MethodsThe Surveillance, Epidemiology and End Results–Medicare data for patients with HNC diagnosed between 2002 and 2011 was utilized to evaluate posttreatment rehabilitation.ResultsIn 16 194 patients, the overall utilization rate was 20.7% for SLP and 26.2% for OT/PT services. Treatment modality was significantly associated rehabilitation utilization. Compared to patients treated with primary surgery, those treated with primary radiotherapy had significantly lower odds of OT/PT utilization. Patients treated with surgery plus adjuvant treatment and primary concurrent chemoradiation had higher odds of SLP utilization compared to patients treated with surgery alone.ConclusionsRehabilitation services appeared to be underutilized by patients with HNC in the United States and vary with treatment modality. There is a need to improve integration of rehabilitation services into the HNC care continuum.SummaryRehabilitation services are underutilized by patients with HNC during posttreatment surveillance in the United States. Treatment modality significantly impacts rehabilitation utilization patterns.
Impact of a pharmacist‐administered long‐acting injectable antipsychotic service in a supermarket‐based community pharmacy on medication adherence
Authors: Lin Christine , Strauss Rebecca , Hong Jenny , Hamper Jeffrey G. , Hoy Emma Sew , Lazar Ann A. , Kroon Lisa 
Published: June 2019

AbstractIntroductionLong‐acting injectable antipsychotic (LAIA) medications can improve medication adherence in patients with schizophrenia and bipolar disorder due to their 1‐ to 3‐month administration schedules.ObjectivesThe primary objective of this study was to examine the effect of a pharmacist‐administered LAIA service in a supermarket‐based community pharmacy on medication adherence rates.MethodsIn this descriptive study, service data from July 1, 2017 through February 28, 2018 were obtained from a national chain pharmacy. The study population included all patients utilizing the pharmacist‐administered LAIA service who received one of the following LAIA medications during the study period: aripiprazole, aripiprazole lauroxil, paliperidone palmitate, and risperidone. Patients under the age of 18 and those who received fewer than two pharmacist administrations of the same medication were excluded. Medication adherence was measured using the proportion of days covered (PDC) with ≥80% being considered adherent. Logistic regression analysis was performed to identify factors that affected PDC.ResultsA total of 78% (500/641) of patients enrolled in the service were determined to be adherent to their LAIA. Statistically significant differences were found between PDC rates based on medication selection. Using aripiprazole (Abilify Maintena) as a reference, patients on paliperidone palmitate (Invega Sustenna), paliperidone palmitate (Invega Trinza), and risperidone (Risperdal Consta) were 2.1 (95% CI 1.3‐3.3, P < .002), 4.4 (95% CI 1.8‐11.2, P < .002), and 4.3 (95% CI 1.6‐11.8, P < .004) times more likely to have a PDC ≥80%, respectively.ConclusionA majority of patients (78%) enrolled in a community pharmacy‐based service in which pharmacists‐administered LAIA medications were shown to be adherent to their medication. Specific LAIA medications were found to be associated with greater medication adherence. Findings from this study will provide insight into effective means of care delivery for other community‐based specialty pharmacy programs.
Preclinical evaluation of porcine colon resection using hollow core negative curvature fibre delivered ultrafast laser pulses
Authors: Mohanan Syam M. P. C. , Beck Rainer J. , West Nicholas P. , Shires Michael , Perry Sarah L. , Jayne David G. , Hand Duncan P. , Shephard Jonathan D. 
Published: June 2019

AbstractUltrashort pulse lasers offer great promise for tissue resection with exceptional precision and minimal thermal damage. Surgery in the bowel requires high precision and minimal necrotic tissue to avoid severe complications such as perforation. The deployment of ultrashort lasers in minimally invasive or endoscopic procedures has been hindered by the lack of suitable optical fibres for high peak powers. However, recent developments of hollow core microstructured fibres provide potential for delivery of such pulses throughout the body. In this study, analysis of laser ablation via a scanning galvanometer on a porcine colon tissue model is presented. A thermally damaged region (<85 μm) and fine depth control of ablation using the pulse energies 46 and 33 μJ are demonstrated. It is further demonstrated that such pulses suitable for precision porcine colon resection can be flexibly delivered via a hollow core negative curvature fibre (HC‐NCF) and again ablation depth can be controlled with a thermally damaged region <85 μm. Ablation volumes are comparable to that of early stage lesions in the inner lining of the colon. This study concludes that the combination of ultrashort pulses and flexible fibre delivery via HC‐NCF present a viable route to new minimally invasive surgical procedures.
Biocompatibility evaluation of bioprinted decellularized collagen sheet implanted in vivo cornea using swept‐source optical coherence tomography
Authors: Park Jaeseok , Lee Kyoung‐Pil , Kim Hyeonji , Park Sungjo , Wijesinghe Ruchire E. , Lee Jaeyul , Han Sangyeob , Lee Sangbong , Kim Pilun , Cho Dong‐Woo , Jang Jinah , Kim Hong K. , Jeon Mansik , Kim Jeehyun 
Published: June 2019

AbstractCorneal transplantation by full‐thickness penetrating keratoplasty with human donor tissue is a widely accepted treatment for damaged or diseased corneas. Although corneal transplantation has a high success rate, a shortage of high‐quality donor tissue is a considerable limitation. Therefore, bioengineered corneas could be an effective solution for this limitation, and a decellularized extracellular matrix comprises a promising scaffold for their fabrication. In this study, three‐dimensional bioprinted decellularized collagen sheets were implanted into the stromal layer of the cornea of five rabbits. We performed in vivo noninvasive monitoring of the rabbit corneas using swept‐source optical coherence tomography (OCT) after implanting the collagen sheets. Anterior segment OCT images and averaged amplitude‐scans were acquired biweekly to monitor corneal thickness after implantation for 1 month. The averaged cornea thickness in the control images was 430.3 ± 5.9 μm, while the averaged thickness after corneal implantation was 598.5 ± 11.8 μm and 564.5 ± 12.5 μm at 2 and 4 weeks, respectively. The corneal thickness reduction of 34 μm confirmed the biocompatibility through the image analysis of the depth‐intensity profile base. Moreover, hematoxylin and eosin staining supported the biocompatibility evaluation of the bioprinted decellularized collagen sheet implantation. Hence, the developed bioprinted decellularized collagen sheets could become an alternative solution to human corneal donor tissue, and the proposed image analysis procedure could be beneficial to confirm the success of the surgery.