bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inequalities in women's awareness of changes to the State Pension Age in England and the role of cognitive ability
Authors: Holman Daniel , Foster Liam , Hess Moritz 
Published: August 2018

AbstractAs a response to the ageing population, the United Kingdom (UK) government, like many others, has increased the State Pension Age. This has involved equalising women's State Pension Age with men's, raising it from 60 to 65, with further increases already underway. It has been argued that a key issue with how this change has been implemented is the lack of notice the government gave to the women affected, impacting on their ability to plan for retirement. So far, there has been very little research exploring inequalities in awareness of these developments and, in particular, considering whether women of particular socio-economic backgrounds are less likely to know about the changes. This has implications for potentially further widening inequalities in old age. In this paper we analyse data from the English Longitudinal Study of Ageing. We consider the role of cognitive ability in mediating the relationship between socio-economic background and awareness, given recent debates on deficiencies in financial literacy. We find that socio-economic inequalities exist, especially with respect to labour force status, occupation and education. We also find that cognitive ability, especially numeracy, mediates a sizeable proportion of the relationship. These findings have important implications in terms of implementing future policy changes and awareness campaigns to help mitigate the possibility that they will further entrench inequalities in older age.
Using Lake Sediment Cores to Improve Records of Volcanism at Aluto Volcano in the Main Ethiopian Rift
Authors: McNamara K. , Cashman K. V. , Rust A. C. , Fontijn K. , Chalié F. , Tomlinson E. L. , Yirgu G. 
Published: August 2018

AbstractAluto is a silicic volcano in central Ethiopia, flanked by two large population centers and home to an expanding geothermal power plant. Here we present data from two lake sediment cores sampled 12 and 25 km from the volcano, which record at least 24 distinct eruptions in the Holocene. Tephra layers from the two cores are correlated using a variety of techniques, including major and trace element geochemistry as well as textural and morphological features from scanning electron microscopy‐backscatter electron imaging. The purpose is to provide a Holocene reference section for further tephrostratigraphic studies of the volcano as well as to provide information on eruption frequency. The lake cores suggest that Aluto has had a variable eruption rate, with three eruption clusters in the Holocene at ~3, 6.5, and 11 ka, with small Vulcanian‐to sub‐Plinian eruptions separated by larger, Plinian eruptions. We infer that the smaller tephras are likely the product of pumice cone‐ and dome‐forming eruptions. In addition, modern wind data suggest that the likely direction of an ash cloud from Aluto is to the west and south west, which is toward population centers and is in agreement with thickness data from the cores. We conclude that current records underestimate the volcano's eruptive history and that hazard assessments should be updated accordingly.
A Statistical Survey of Radiation Belt Dropouts Observed by Van Allen Probes
Authors: Xiang Zheng , Tu Weichao , Ni Binbin , Henderson M. G. , Cao Xing 
Published: August 2018

AbstractA statistical analysis on the radiation belt dropouts is performed based on 4 years of electron phase space density data from the Van Allen Probes. The μ, K, and L* dependence of dropouts and their driving mechanisms and geomagnetic and solar wind conditions are investigated using electron phase space density data sets for the first time. Our results suggest that electronmagnetic ion cyclotron (EMIC) wave scattering is the dominant dropout mechanism at low L* region, which requires the most active geomagnetic and solar wind conditions. In contrast, dropouts at high L* have a higher occurrence and are due to a combination of EMIC wave scattering and outward radial diffusion associated with magnetopause shadowing. In addition, outward radial diffusion at high L* is found to cause larger dropouts than EMIC wave scattering and is accompanied with active geomagnetic and solar wind drivers.
Why Do Large‐Scale Land Surface Models Produce a Low Ratio of Transpiration to Evapotranspiration?
Authors: Chang Li‐Ling , Dwivedi Ravindra , Knowles John F. , Fang Yuan‐Hao , Niu Guo‐Yue , Pelletier Jon D. , Rasmussen Craig , Durcik Matej , Barron‐Gafford Greg A. , Meixner Thomas 
Published: August 2018

AbstractMost land surface models (LSMs) used in Earth System Models produce a lower ratio of transpiration (T) to evapotranspiration (ET) than field observations, degrading the credibility of Earth System Model‐projected ecosystem responses and feedbacks to climate change. To interpret this model deficiency, we conducted a pair of model experiments using a three‐dimensional, process‐based ecohydrological model in a subhumid, mountainous catchment. One experiment (CTRL) describes lateral water flow, topographic shading, leaf dynamics, and water vapor diffusion in the soil, while the other (LSM like) does not explicitly describe these processes to mimic a conventional LSM using artificially flattened terrain. Averaged over the catchment, CTRL produced a higher T/ET ratio (72%) than LSM like (55%) and agreed better with an independent estimate (79.79 ± 27%) based on rainfall and stream water isotopes. To discern the exact causes, we conducted additional model experiments, each reverting only one process described in CTRL to that of LSM like. These experiments revealed that the enhanced T/ET ratio was mostly caused by lateral water flow and water vapor diffusion within the soil. In particular, terrain‐driven lateral water flows spread out soil moisture to a wider range along hillslopes with an optimum subrange from the middle to upper slopes, where evaporation (E) was more suppressed by the drier surface than T due to plant uptake of deep soil water, thereby enhancing T/ET. A more elaborate representation of water vapor diffusion from a dynamically changing evaporating surface to the height of the surface roughness length reduced E and increased the T/ET ratio.
Model‐Based Analysis of the Effects of Dam‐Induced River Water and Groundwater Interactions on Hydro‐Biogeochemical Transformation of Redox Sensitive Contaminants in a Hyporheic Zone
Authors: Yang Chen , Zhang You‐Kuan , Liu Yuanyuan , Yang Xiaofan , Liu Chongxuan 
Published: August 2018

AbstractBiogeochemical processes in the hyporheic zone (HZ) may retard the contaminants migration from groundwater to the river and vice versa. Anthropogenic activities may further complicate such processes. This study investigated the effects of dam‐induced hydrodynamics on biogeochemical transformation of contaminants using Cr as an example in the HZ of the Columbia River at the U.S. Department of Energy's Hanford Site. The flow velocities in the HZ were first simulated using the measured or averaged groundwater level and river stage at hourly, daily, weekly, and monthly time scales. The flow velocities were then incorporated into a reactive transport model with independently characterized biogeochemical reactions and kinetics. Simulation results indicated that hydrodynamics can significantly influence the rate and extent of Cr (VI) biogeochemical transformation, which was mainly controlled by the kinetic reduction of Cr (VI) to sparely soluble Cr (III) by sediment‐associated Fe (II) that can be regenerated by microorganisms with organic carbon as electron donor. The frequent flow direction reversals in the HZ induced by dam operations enhanced the rate of microbial consumption of bioavailable OC, which, if there was no organic carbon supply, can eventually terminate the Fe (II) regeneration mechanism and exhaust the HZ's redox capacity in reducing Cr (VI) to Cr (III). This study demonstrated the importance of hydrodynamics on biogeochemical transformation of contaminants in the HZ and of the time scales used in assessing the reactive transport of chemicals and contaminants in the HZ as the net supply of redox sensitive chemicals such as dissolved oxygen into the HZ is a function of the frequency of flow direction reversal.
Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress
Authors: Seo Seung Un , Min Kyoung-jin , Woo Seon Min , Kwon Taeg Kyu 
Published: August 2018

AbstractMultiple cancer cells highly express cathepsin S, which has pro-tumoral effects. However, it was previously unknown whether knockdown or a pharmacological inhibitor (ZFL) of cathepsin S acts as an inducer of ER stress. Here, ZFL and knockdown of cathepsin S markedly induced ER stress through the up-regulation of calcium levels in the cytosol. Induction of calcium levels by inhibition of cathepsin S is markedly blocked by an inhibitor of the IP3 receptor and the ryanodine receptor Ca2+ channel in the ER, but an inhibitor of a mitochondrial Ca2+ uniporter had no effect on ZFL-induced calcium levels. Furthermore, production of mitochondrial ROS by ZFL was associated with an increase in cytosolic calcium levels. ZFL-mediated ER stress enhanced anti-cancer drug-induced apoptotic cell death, and pretreatment with chemical chaperones or down-regulation of ATF4 and CHOP by small interfering RNA markedly reduced ZFL plus oxaliplatin-induced apoptosis. Taken together, our findings reveal that inhibition of cathepsin S is an inducer of ER stress; these findings may contribute to the enhancement of therapeutic efficiency in cancer cells.
Crystallographic character of grain boundaries resistant to hydrogen-assisted fracture in Ni-base alloy 725
Authors: Hanson John P. , Bagri Akbar , Lind Jonathan , Kenesei Peter , Suter Robert M. , Gradečak Silvija , Demkowicz Michael J. 
Published: August 2018

AbstractHydrogen embrittlement (HE) causes sudden, costly failures of metal components across a wide range of industries. Yet, despite over a century of research, the physical mechanisms of HE are too poorly understood to predict HE-induced failures with confidence. We use non-destructive, synchrotron-based techniques to investigate the relationship between the crystallographic character of grain boundaries and their susceptibility to hydrogen-assisted fracture in a nickel superalloy. Our data lead us to identify a class of grain boundaries with striking resistance to hydrogen-assisted crack propagation: boundaries with low-index planes (BLIPs). BLIPs are boundaries where at least one of the neighboring grains has a low Miller index facet—{001}, {011}, or {111}—along the grain boundary plane. These boundaries deflect propagating cracks, toughening the material and improving its HE resistance. Our finding paves the way to improved predictions of HE based on the density and distribution of BLIPs in metal microstructures.
Vertebrate myosin 1d regulates left–right organizer morphogenesis and laterality
Authors: Saydmohammed Manush , Yagi Hisato , Calderon Michael , Clark Madeline J. , Feinstein Timothy , Sun Ming , Stolz Donna B. , Watkins Simon C. , Amack Jeffrey D. , Lo Cecilia W. , Tsang Michael 
Published: August 2018

AbstractEstablishing left–right asymmetry is a fundamental process essential for arrangement of visceral organs during development. In vertebrates, motile cilia-driven fluid flow in the left–right organizer (LRO) is essential for initiating symmetry breaking event. Here, we report that myosin 1d (myo1d) is essential for establishing left–right asymmetry in zebrafish. Using super-resolution microscopy, we show that the zebrafish LRO, Kupffer’s vesicle (KV), fails to form a spherical lumen and establish proper unidirectional flow in the absence of myo1d. This process requires directed vacuolar trafficking in KV epithelial cells. Interestingly, the vacuole transporting function of zebrafish Myo1d can be substituted by myosin1C derived from an ancient eukaryote, Acanthamoeba castellanii, where it regulates the transport of contractile vacuoles. Our findings reveal an evolutionary conserved role for an unconventional myosin in vacuole trafficking, lumen formation, and determining laterality.
Selectively nitrogen-doped carbon materials as superior metal-free catalysts for oxygen reduction
Authors: Lv Qing , Si Wenyan , He Jianjiang , Sun Lei , Zhang Chunfang , Wang Ning , Yang Ze , Li Xiaodong , Wang Xin , Deng Weiqiao , Long Yunze , Huang Changshui , Li Yuliang 
Published: August 2018

AbstractDoping with pyridinic nitrogen atoms is known as an effective strategy to improve the activity of carbon-based catalysts for the oxygen reduction reaction. However, pyridinic nitrogen atoms prefer to occupy at the edge or defect sites of carbon materials. Here, a carbon framework named as hydrogen-substituted graphdiyne provides a suitable carbon matrix for pyridinic nitrogen doping. In hydrogen-substituted graphdiyne, three of the carbon atoms in a benzene ring are bonded to hydrogen and serve as active sites, like the edge or defect positions of conventional carbon materials, on which pyridinic nitrogen can be selectively doped. The as-synthesized pyridinic nitrogen-doped hydrogen-substituted graphdiyne shows much better electrocatalytic performance for the oxygen reduction reaction than that of the commercial platinum-based catalyst in alkaline media and comparable activity in acidic media. Density functional theory calculations demonstrate that the pyridinic nitrogen-doped hydrogen-substituted graphdiyne is more effective than pyridinic nitrogen-doped graphene for oxygen reduction.
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
Authors: Han Xuexiang , Li Yiye , Xu Ying , Zhao Xiao , Zhang Yinlong , Yang Xiao , Wang Yongwei , Zhao Ruifang , Anderson Gregory J. , Zhao Yuliang , Nie Guangjun 
Published: August 2018

AbstractPancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs) play a key role in establishing this unique pathological obstacle, but also offer a potential target for anti-tumour therapy. Here, we construct a tumour microenvironment-responsive nanosystem, based on PEGylated polyethylenimine-coated gold nanoparticles, and utilise it to co-deliver all-trans retinoic acid (ATRA, an inducer of PSC quiescence) and siRNA targeting heat shock protein 47 (HSP47, a collagen-specific molecular chaperone) to re-educate PSCs. The nanosystem simultaneously induces PSC quiescence and inhibits ECM hyperplasia, thereby promoting drug delivery to pancreatic tumours and significantly enhancing the anti-tumour efficacy of chemotherapeutics. Our combination strategy to restore homoeostatic stromal function by targeting activated PSCs represents a promising approach to improving the efficacy of chemotherapy and other therapeutic modalities in a wide range of stroma-rich tumours.
Assessing modern river sediment discharge to the ocean using satellite gravimetry
Authors: Mouyen Maxime , Longuevergne Laurent , Steer Philippe , Crave Alain , Lemoine Jean-Michel , Save Himanshu , Robin Cécile 
Published: August 2018

AbstractRecent acceleration of sand extraction for anthropic use threatens the sustainability of this major resource. However, continental erosion and river transport, which produce sand and sediment in general, lack quantification at the global scale. Here, we develop a new geodetic method to infer the sediment discharge to ocean of the world’s largest rivers. It combines the spatial distribution of modern sedimentation zones with new high-resolution (~170 km) data from the Gravity Recovery and Climate Experiment (GRACE) mission launched in 2002. We obtain sediment discharges consistent with in situ measurements for the Amazon, Ganges-Brahmaputra, Changjiang, Indus, and Magdalena rivers. This new approach enables to quantitatively monitor the contemporary erosion of continental basins drained by rivers with large sediment discharges and paves the way toward a better understanding of how natural and anthropic changes influence landscape dynamics.
CTD-dependent and -independent mechanisms govern co-transcriptional capping of Pol II transcripts
Authors: Noe Gonzalez Melvin , Sato Shigeo , Tomomori-Sato Chieri , Conaway Joan W. , Conaway Ronald C. 
Published: August 2018

AbstractCo-transcriptional capping of RNA polymerase II (Pol II) transcripts by capping enzyme proceeds orders of magnitude more efficiently than capping of free RNA. Previous studies brought to light a role for the phosphorylated Pol II carboxyl-terminal domain (CTD) in activation of co-transcriptional capping; however, CTD phosphorylation alone could not account for the observed magnitude of activation. Here, we exploit a defined Pol II transcription system that supports both CTD phosphorylation and robust activation of capping to dissect the mechanism of co-transcriptional capping. Taken together, our findings identify a CTD-independent, but Pol II-mediated, mechanism that functions in parallel with CTD-dependent processes to ensure optimal capping, and they support a “tethering” model for the mechanism of activation.
Crystal structure of human Mediator subunit MED23
Authors: Monté Didier , Clantin Bernard , Dewitte Frédérique , Lens Zoé , Rucktooa Prakash , Pardon Els , Steyaert Jan , Verger Alexis , Villeret Vincent 
Published: August 2018

AbstractThe Mediator complex transduces regulatory information from enhancers to promoters and performs essential roles in the initiation of transcription in eukaryotes. Human Mediator comprises 26 subunits forming three modules termed Head, Middle and Tail. Here we present the 2.8 Å crystal structure of MED23, the largest subunit from the human Tail module. The structure identifies 25 HEAT repeats-like motifs organized into 5 α-solenoids. MED23 adopts an arch-shaped conformation, with an N-terminal domain (Nter) protruding from a large core region. In the core four solenoids, motifs wrap on themselves, creating triangular-shaped structural motifs on both faces of the arch, with extended grooves propagating through the interfaces between the solenoid motifs. MED23 is known to interact with several specific transcription activators and is involved in splicing, elongation, and post-transcriptional events. The structure rationalizes previous biochemical observations and paves the way for improved understanding of the cross-talk between Mediator and transcriptional activators.
Quantifying the role of surface plasmon excitation and hot carrier transport in plasmonic devices
Authors: Tagliabue Giulia , Jermyn Adam S. , Sundararaman Ravishankar , Welch Alex J. , DuChene Joseph S. , Pala Ragip , Davoyan Artur R. , Narang Prineha , Atwater Harry A. 
Published: August 2018

AbstractHarnessing photoexcited “hot” carriers in metallic nanostructures could define a new phase of non-equilibrium optoelectronics for photodetection and photocatalysis. Surface plasmons are considered pivotal for enabling efficient operation of hot carrier devices. Clarifying the fundamental role of plasmon excitation is therefore critical for exploiting their full potential. Here, we measure the internal quantum efficiency in photoexcited gold (Au)–gallium nitride (GaN) Schottky diodes to elucidate and quantify the distinct roles of surface plasmon excitation, hot carrier transport, and carrier injection in device performance. We show that plasmon excitation does not influence the electronic processes occurring within the hot carrier device. Instead, the metal band structure and carrier transport processes dictate the observed hot carrier photocurrent distribution. The excellent agreement with parameter-free calculations indicates that photoexcited electrons generated in ultra-thin Au nanostructures impinge ballistically on the Au–GaN interface, suggesting the possibility for hot carrier collection without substantial energy losses via thermalization.
Sentinel lymph node B cells can predict disease-free survival in breast cancer patients
Authors: Blenman Kim R. M. , He Ting-Fang , Frankel Paul H. , Ruel Nora H. , Schwartz Erich J. , Krag David N. , Tan Lee K. , Yim John H. , Mortimer Joanne E. , Yuan Yuan , Lee Peter P. 
Published: August 2018

AbstractTumor invasion into draining lymph nodes, especially sentinel lymph nodes (SLNs), is a key determinant of prognosis and treatment in breast cancer as part of the TNM staging system. Using multicolor histology and quantitative image analysis, we quantified immune cells within SLNs from a discovery cohort of 76 breast cancer patients. We found statistically more in situ CD3+ T cells in tumor negative vs. tumor positive nodes (mean of 8878 vs. 6704, respectively, p = 0.006), but no statistical difference in CD20+ B cells or CD1a+ dendritic cells. In univariate analysis, a reduced hazard was seen with a unit increase in log CD3 with HR 0.49 (95% CI 0.30–0.80) and log CD20 with HR 0.37 (95% CI 0.22–0.62). In multivariate analysis, log CD20 remained significant with HR 0.42 (95% CI 0.25–0.69). When restricted to SLN tumor negative patients, increased log CD20 was still associated with improved DFS (HR = 0.26, 95% CI 0.08–0.90). The CD20 results were validated in a separate cohort of 21 patients (n = 11 good outcome, n = 10 poor outcome) with SLN negative triple-negative breast cancer (TNBC) (“good” mean of 7011 vs. “poor” mean of 4656, p = 0.002). Our study demonstrates that analysis of immune cells within SLNs, regardless of tumor invasion status, may provide additional prognostic information, and highlights B cells within SLNs as important in preventing future recurrence.
Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity
Authors: Lui Simon , Torontali Zoltan , Tadjalli Arash , Peever John 
Published: August 2018

AbstractThe respiratory control system is plastic. It has a working memory and is capable of retaining how respiratory stimuli affect breathing by regulating synaptic strength between respiratory neurons. For example, repeated airway obstructions trigger a form of respiratory plasticity that strengthens inspiratory activity of hypoglossal (XII) motoneurons. This form of respiratory plasticity is known as long-term facilitation (LTF) and requires noradrenaline released onto XII motoneurons. However, the brainstem regions responsible for this form of LTF remain unidentified. Here, we used electrophysiology, neuropharmacology and immunohistochemistry in adult rats to identify the brainstem regions involved in mediating LTF. First, we show that repeated airway obstructions induce LTF of XII motoneuron activity and that inactivation of the noradrenergic system prevents LTF. Second, we show that noradrenergic cells in the locus coeruleus (LC), which project to XII motoneurons, are recruited during LTF induction. Third, we show that targeted inactivation of noradrenergic LC cells during LTF induction prevents LTF. And lastly, we show that the nucleus tractus solitarius (NTS), which has known projections to the LC, is critical for LTF because its inactivation prevents LTF. Our results suggest that both the LC and NTS are involved in mediating apnea-induced LTF, and we hypothesize that a NTS → LC → XII circuit mechanism mediates this form of respiratory motor plasticity.