bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Efficacy of Levetiracetam for the Management of Levodopa- Induced Dyskinesia in Patients with Parkinson’s Disease: A Systematic Review
Authors: Ebada Mahmoud A. , Alkanj Souad , Ebada Mohamed , Abdelkarim Ahmed H. , Diab Ahmed , Aziz Mohamed A.E. , Soliman Ahmed M. , Fayed Notila , Bahbah Eshak I. , Negida Ahmed 
Published: March 2019

Background:
Levetiracetam, a novel antiepileptic drug, has shown antidyskinetic effects in
experimental animal models of Parkinson's disease (PD). The tolerability and efficacy of levetiracetam
in reducing the levodopa-induced dyskinesia (LID) in PD patients have not been established. Therefore,
this study aims to synthesize evidence from published prospective clinical trials about the efficacy
of levetiracetam for the management of LID in PD patients.

Methods:
We followed the PRISMA statement guidelines during the preparation of this systematic review.
A computer literature search of PubMed, EBSCO, Scopus, MEDLINE, and the web of science
was carried out. We selected prospective clinical trials assessing the anti-dyskinetic efficacy of
levetiracetam for treating LID in patients with PD. The Abnormal Involuntary Movement Scale
(AIMS), Clinical Global Impression Score (GCI), UPDRS III, and UPDRS IV were considered as the
primary outcome measures; their data were extracted and reviewed.

Results:
Our review included seven clinical trials with a total of 150 patients. Of them, three studies
were randomized controlled trials, and the remaining were open-label single arm trials. Four studies
reported poor tolerability of the levetiracetam with mild anti-dyskinetic effects. Levetiracetam slightly
improved the UPDRS-IV and AIMS scores with small effect size. In the remaining three studies,
levetiracetam failed to exhibit any anti-dyskinetic effects.

Conclusion:
Current evidence does not support the efficacy of the levetiracetam for treating LID in
PD patients, however, due to the limited number of published randomized control trials (RCTs), further
RCTs are required.
Evaluation of Second Generation Antipsychotics, as Augmentative Plan, in Treatment-Resistant Obsessive-Compulsive Disorder
Authors: Shafti Saeed S. , Kaviani Hamid 
Published: March 2019

Introduction:
Since around half of the patients with obsessive-compulsive disorder
do not respond efficiently to current serotonin- reuptake inhibitors, the objective of
the present study was to compare the effectiveness and safety of quetiapine against aripiprazole
in patients with obsessive-compulsive disorder, who had not responded successfully
to fluvoxamine.

Methods:
Forty-four patients with obsessive-compulsive disorder, who had not responded
efficaciously to fluvoxamine, at maximum dose (300 milligrams per day) and duration
(twelve weeks), were allocated randomly in a double-blind assessment to take quetiapine
(n=22) or aripiprazole (n=22), plus their serotonin-reuptake inhibitor for twelve weeks.
While treatment response was evaluated by the Yale- Brown Obsessive-Compulsive Scale
(YBOCS), as the main outcome scale, Clinical Global Impressions-Severity Scale (CGI-S)
was also used as an ancillary measure.

Results:
54.54% of patients in the quetiapine group and 27.27% of them in the aripiprazole
group responded partially to the abovementioned on treatment adds. According to the findings,
the YBOCS score dropped from 31.18+/-4.93 to 27.97+/-3.71 (p<0.01), and 33.27 +/- 3.90
to 30.72+/-4.67 (p < 0.06), for quetiapine and aripiprazole, respectively. In this regard, no
substantial alteration regarding CGI-S was evident in each of the aforementioned groups.

Conclusion:
This assessment indicated that patients with treatment-resistant obsessivecompulsive
disorder could benefit more from adding quetiapine, in comparison with aripiprazole,
to their current serotonergic medication.
Pengembangan lembar kerja peserta didik kimia berbasis inkuiri terbimbing untuk kelas Xi IPA SMA/MA
Authors: Rizalini Rina , Sofyan Herminarto 
Published: March 2019

Penelitian ini bertujuan untuk: (1) menghasilkan Lembar Kerja Peserta Didik (LKPD) kimia berbasis inkuiri terbimbing yang layak untuk peserta didik kelas XI IPA SMA, (2) mengetahui kepraktisan LKPD berbasis inkuiri terbimbing, dan (3) mengetahui keefektifan LKPD berbasis inkuiri terbimbing. Penelitian ini merupakan penelitian dan pengembangan yang menggunakan model Thiagarajan. Prosedur pengembangan meliputi tahap pendefinisian, perancangan, dan pengembangan. Tahap pendefinisian dilakukan survei untuk menganalisis permasalahan dan kebutuhan peserta didik. Tahap perancangan disesuaikan dengan kebutuhan dalam kegiatan pembelajaran. Tahap pengembangan dilakukan validasi ahli materi dan media kemudian diimplementasikan di kelas XI IPA SMAN 2 Wates pada 20 peserta didik. Hasil penelitian menunjukkan bahwa: (1) Hasil validasi LKPD kimia yang dikembangkan dikategorikan layak berdasarkan hasil validasi ahli materi dengan rerata skor 3,8 dan ahli media dengan rerata skor 4,0, (2) tingkat kepraktisan LKPD berada dalam kategori sangat baik, dan (3) keefektifan LKPD memperoleh sig < 0,05 membuktikan ada perbedaan yang signifikan antara kelas eksperimen dan kontrol.Kata Kunci: lembar kerja peserta didik, kimia, inkuiri terbimbing DEVELOPING CHEMISTRY WORKSHEETS BASED ON GUIDED INQUIRY FOR THE SECOND GRADE STUDENTS OF SENIOR HIGH SCHOOLAbstractThis research study aims to: (1) produce valid chemistry worksheets based on guided inquiry for the second grade students of senior high school, (2) know the practically of worksheets based on guided inquiry, and (3) know the effectiveness of worksheets based on guided inquiry. This study was research and development using the Thiagarajan model. The procedure of the development included the steps of defining, designing, and developing. In the defining step, a survey to analyze the problems and student’s needs. The designing step, was conducted the needs of the learning activities. The development step a validation was done by materials and media experts then implementation in class XI science of SMAN 2 Wates to 20 students. The result of the study shows: (1) the chemistry worksheets produced fullfills the appropriateness criteria based on the result of materials experts with the mean score 3.8 and media experts is 4.0 which is in a good category, (2) the practically level is in the very good category, and (3) the effectiveness of worksheets obtaining sig < 0.05 proves there is a significant difference between the experimental and control class.Keywords: worksheets, chemistry, guided inquiry
Akseptabilitas Es Krim dengan Fortifikasi Mesocarp Lontar (Borassus flabeliffer L.) sebagai Antioksidan dan Serat Pangan Alami
Authors: Idayati Eny , Bele Agrippina Agnes , Sir Rikka Welhelmina 
Published: March 2019

Lontar palm (Borassus flabeliffer L.) fruit is one of the specific tropical fruits from East Nusa Tenggara province (NTT)-Indonesia that is rich in functional compounds such as beta-carotene as an antioxidant and food fiber. However, the utilization of these fruits is still limited due to the streroidal saponins and pholifenol content that makes them taste bitter and less favored by consumers. Therefore, one alternative that can be done is by enriching them into ice cream products. The production of Ice cream cannot go through with high heating processing so that the antioxidants extracted from lontar palm mesocarp can be in a stable condition. The aim of this study is to investigate the effect of ice cream on the acceptability values of the hedonic test, determining of fiber and beta-carotene content and evaluating antioxidant activities fortification from the lontar's mesocarp. The amount of lontar mesocarp for fortification (F) were 30%, 40% and 50% of the wet weight with the combination of some variation of milk treatment such as full cream milk, sweetened condensed milk, and liquid soy milk. The acceptability of the product was tested using hedonic test against color, aroma, texture, and flavor parameter. Antioxidant activity was performed by determination of the DPPH value (1.1-diphenyl-2picryhydrazil radical-scavenging), dietary fiber using enzymatic-gravimetric methods and UV-Vis spectrophotometers to analyze the content of beta-carotene. The results showed that on the acceptability test, the most preferred samples valued by panelists were the fortification, F1 treatment (30%) with the content of β-carotene of full cream milk was 2212.44 ± 11.82 μg /100 mg, dietary fiber was 8.95 ± 0.05%, and antioxidant activity was 45.54 ± 0.36%.
Sifat Fungsional Pati Ubi Kelapa Kuning (Dioscorea alata) dan Pemanfaatannya sebagai Pengental pada Saus Tomat
Authors: Ulyarti U , Lavlinesia L , Nuzula N , Nazarudin N 
Published: March 2019

The aim of this research was to determine the functional properties of yellow greater yam’s starch (Dioscorea alata) and its ability to acts as thickening agent for tomato sauce. This research was carried out in 2 stages: starch extraction followed by determination of its physical and functional properties and production of tomato sauce using completely randomized design with 5 levels of starch concentration and 4 replications. The levels were 0, 1, 2, 3 and 4% which was calculated from tomato pulps. Functional properties of yellow greater yam’s starch showed the capability as thickening agent but had quite high setback value. The result showed that the concentration of yellow greater yam’s starch significantly affect viscosity and syneresis (p <0 .01) and a* value (p < 0.05) but did not affect water content, total soluble solid, L* and b* of the tomato sauce. Although creates an obvious color difference (ΔE>3), the concentration of 2% yellow greater yam’s starch is proposed to be used as thickening agent in tomato sauce producing tomato sauce without syneresis during a week of storage, viscosity 4.85 Poise, total soluble solid 44.8 obrix, L* 50.75, a* 50.75, b* 51.30 and overal acceptance “rather like” to “like”.
Da rachadura no espelho aos processos de subjetivação do sujeito-mulher em (des)constituição em páginas feministas brasileiras na web (From the cracking in the mirror to the subjectivation procedures of the subject-woman in deconstitution on brazilian)
Authors: Silva Mariana Morales da , Rosa Mariana Guidetti 
Published: March 2019

Com o objetivo de compreender como se dá a subjetivação do sujeito "mulher" e como o discurso feminista se manifesta na web, propõe-se demonstrar uma análise de uma postagem da página do Facebook "Empodere Duas Mulheres", que se diz feminista, e também dos comentários da mesma postagem. A pesquisa está ancorada na Análise do Discurso de orientação francesa de Michel Pêcheux, nas teorias sobre hipergênero e cenografia propostas por Dominique Maingueneau, e também nos conceitos de poder e modos de subjetivação de Michel Foucault.PALAVRAS-CHAVE: Discurso. Hipergênero. Feminismo. Cenografia.
Membangun strategi memenangkan pasar persaingan pada toko pakaian di kota Tegal
Authors: Sujarwo Makmur , Soebroto Setyowati 
Published: March 2019

Abstract : This research is aimed to find out how far the improvement of store operation excellence, the increase of store communication effectiveness (visual merchandising), area trading optimization, focused marketing activity and community involvement have been built in clothing stores in Tegal city so that the retailers can win market competition.This study used a sample of 100 clothing stores in the city of Tegal as respondents. Respondents' answers to the closed questions about the variables studied in this study were then analyzed by using Multiple Regression Test while the answer to the open question was analyzed qualitatively.The results of this study indicate that increased communication effectiveness in the shop, focused marketing activities and community involvement significantly influence the strategy to win the clothing store retail market in the city of Tegal. For that it should be clothing store retailers can further improve these three variables to win more competitive market.Of the five variables above, the community involvement variable has the greatest effect for retailers to win the competition market with a score of 0.251. So a retailer to be more active in social activities by providing compensation to the poor and orphans. Keywords: Market winning strategy, excellence store operations, visual merchandising, area trading optimization, focused marketing activities and community involvement.
Habitat Suitability Analysis for Mountain Lions (Puma Concolor) Recolonization/ Reintroduction in Minnesota
Authors: Mbuh Mbongowo J , Vruno Neil 
Published: March 2019

Abstract
The mountain lion range once extended throughout the state of Minnesota. The breeding population has been greatly reduced with time, new roads, and timber harvesting, which have broken large tracts of contiguous forest into isolated patches that are too small and no longer suitable for the breeding mountain lion population. The objective of this study is to use suitability analysis to determine the most suitable habitat to conserve mountain lion populations threatened by habitat fragmentation. To attain our objective, we created three sub models that contribute to the overarching goal of the suitability model. A habitat sub model was developed for finding the best habitat, a food sub model for access to the maximum amount of food needed, and a security sub model focusing on the distance from houses, roads, and urban development. Using the Weighted Sum tool, the three sub models were combined to produce a suitability surface based on the trade-off of the preferences of the goals represented by each sub model. Our suitability model shows large areas of high-quality mountain lion habitat in the northern and north-eastern sections of the state. These areas contain favourable locations for mountain lion habitat, such as forested land cover, low-density populations, steep slopes, short distances to streams, and area unimpeded by major roads. The southern and western parts of the state are characterized by lower slopes, more agricultural land, grassland, developed land, and higher population density, which results in lower quality habitat. The twin cities have the worst mountain lion habitat.
Aplicación de recubrimiento Céreos como operación postrecolección en frutas
Authors: Gutierrez Guzman Nelson 
Published: March 2019

La calidad innata de nuestros productos hortofrutícolas se consigue con un apropiado control en el campo, pero un adecuado manejo poscosecha que incluya la aplicación de aspectos tecnológicos que determinan una mejora en la calidad, permiten presentar un producto final atractivo al mercado, conservando sus propiedades durante las etapas de almacenamiento, transporte y distribución.
Para dónde va el ambiente, para dónde lo lleva la gente
Authors: Bórbon Ardila Rey Ariel 
Published: March 2019

Cientos de veces se ha dicho, pero no sobra decirlo cientos de veces más, Colombia es un país extremadamente rico en recursos naturales renovables. Los datos, manejados por diferentes organismos dedicados a la conservación ambiental, son contundentes.
Colombia, aseguran, alberga más del 10 % de la biodiversidad mundial, gracias a la innumerable cantidad de especies de fauna y flora que existen sobre su suelo.
De Ben a Ben Jor: hibridismo e trânsitos simbólicos na trajetória do cantor Jorge Ben Jor
Authors: Amaral Marcos 
Published: March 2019

Este texto toma o hibridismo estético da obra de Jorge Ben Jor como elucidativo dos trânsitos simbólicos operados pelo cantor brasileiro que, desafiando circunscrições espaço-temporais tradicionais, tornam o artista um emblema do processo de mundialização da cultura, na medida em que conformam uma materialidade estética calcada na superposição entre local, nacional e mundial. Neste sentido, o “caldeirão de referências musicais” que se apresenta como insumo à criatividade artística do cantor ― estendendo-se da música etíope apresentada pela mãe, chegando ao rock estadunidense de Little Richard e passando pelos sambas-enredos da escola de samba Acadêmicos do Salgueiro ensinados pelo pai ― nos servirá de subsídio para problematizarmos o processo de industrialização do simbólico no Brasil e a interface impreterível que forma em relação ao tema da cultura “popular”, que é ressignificada, articulando-se a um folclore aluvial cuja principal característica é a mestiçagem do ambiente urbano. Assim, a trajetória de Jorge Ben Jor, como lugar idiossincrático onde se cruzam o “intimismo civilizado” da bossa nova e a “expansividade festiva” do samba-enredo, aparecerá como figuração da articulação entre o popular e a mundialização da cultura.
Оцінка впливу мульчування прикущових смуг і зрошення на ріст та продуктивність смородини чорної
Authors: Кучер М. Ф. , Постоленко Л. В. 
Published: March 2019

Наведено результати оцінки сумарного однорічного приросту рослин сортів смородини чорної та проведено оцінку їхньої продуктивності в разі мульчування прикущових смуг та використання зрошення. В результаті проведення досліджень встановлено, що у всіх досліджуваних сортів використання мульчуючих матеріалів у прикущових смугах сприяло істотному збільшенню сумарного однорічного приросту як у варіантах з використанням краплинного зрошення, так і без зрошення на фоні контрольного варіанту – чорний пар. Найвищу продуктивність насаджень смородини чорної забезпечує сумісне використання краплинного зрошення та мульчуючих матеріалів.
The results of estimation of total one-year plants’ increase of sorts of black currant are resulted and estimation of their productivity is conducted at mulching of stripes near bushes and use of irrigation. It is set as a result of researches, that at all explored sorts of the use of mulching materials in stripes near bushes bars was instrumental in the substantial increase of total one-year increase both in variants with the use of tiny irrigation and without irrigation on a background of control variant – black pair. The greatest productivity of planting of black currant provides the compatible use of tiny irrigation and mulching materials.
Біохімічні показники сироватки крові молодняку великої рогатої худоби за трихурозної інвазії
Authors: Шевченко Т. С. 
Published: March 2019

У роботі наведені дані біохімічних показників сироватки крові великої рогатої худоби 6–12-місячного віку за трихурозної інвазії. Встановлено, що паразитування збудника в організмі тварин призводить до змін з боку біохімічних показників, зокрема: у хворого на трихуроз молодняку великої рогатої худоби, в порівнянні з клінічно здоровими тваринами, у сироватці крові значно знижується кількість альбумінів (на 32,7 %, Р<0,01), азоту сечовини (на 23,8 %, Р<0,05), креатиніну (на 44,1 %, Р<0,05), кальцію (на 28,6 %, Р<0,001) та каротину (на 32,4 %, Р<0,05). Водночас встановлене достовірне підвищення рівня АсАт (в 2,7 рази, Р<0,001) та індексу де Рітіса (в 2,4 рази, Р<0,001).
The paper presents data of biochemical parameters of blood serum of cattle 6-12 months of age with tryhurosis invasion. We established that the parasites pathogens leads to changes in the biochemical parameters in animals, including: in patients of young cattle with tryhurosis, compared with clinically healthy animals, in serum of blood significantly reduced amount of albumin (32,7 %, P<0,01), urea nitrogen (23,8 %, P<0,05), creatinine (44,1 %, P<0,05), calcium (28,6 %, P<0,001) and carotene (32,4 %, P<0,05). At the same time we established a significant increase of AST (in 2,7 times, P<0,001) and index de Ritis (in 2,4 times, P<0,001).
Значення еколого-морфологічних особливостей дощових черв’яків (Lumbricidae) Степового Придністров’я та впливу факторів середовища в організації їх угруповань природних, аграрних та урбанізованих екосистем
Authors: Жуков О. В. , Шаталін Д. Б. 
Published: March 2019

У статті запропонована матриця екологічних та еколого-морфологічних особливостей дощових черв’яків. Показано, що ця матриця володіє інформацією, здатною пояснити організацію та функціональну структуру угруповань дощових черв’яків природних, аграрних та урбанізованих екосистем. Умови вологості, які виражені за допомогою кількісної характеристики гігротопу едафотопу, є визначальним фактором, який впливає на організацію угруповань дощових черв’яків, що, у свою чергу, також знаходить своє відображення у еколого-морфологічних особливостях угруповань люмбрицид. Трофотоп має багатовекторний вплив на організацію угруповань дощових черв’яків. Особливості цього впливу також модулюються ценотичними особливостями біоценозів. Показаний характер зв’язку умов вологості та трофності едафотопу з організацією угруповань дощових черв’яків, що також знаходить своє відображення у морфо-екологічних особливостях окремих видів дощових черв’яків. Наведені підтвердженням існування екоморф дощових черв’яків – гігроморф та трофоценоморф.
The paper offers a matrix of environmental and ecological-morphological features of earthworms. It is shown that this matrix has information that could explain the organization and functional structure of the community of earthworms of natural, agricultural and urbanized ecosystems. Humidity conditions, which are expressed by quantitative characteristics of gigrotop of the edaphotop are the determining factor that affects the organization of communities of earthworms, which, in its turn, is also reflected in the ecological and morphological features of lumbricid communities. Trophotopes has a multi-vector impact on the organization of communities of earthworms. Features of this influence are also modulated ceonotic features of the biocenoses. It showed that character of communications of humidity conditions and trophic edaphotop with the organization of communities of earthworms, which also is reflected in the morpho-ecological features of certain types of earthworms. Proofs of existence of earthworms ecomorphes – gigromorphes and trophocenomorphes have been presented.