bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of three-dimensional printing for pre-operative planning in hip preservation surgery
Authors: Bockhorn Lauren , Gardner Stephanie S , Dong David , Karmonik Christof , Elias Saba , Gwathmey F Winston , Harris Joshua D 
Published: June 2019

Abstract

Three-dimensional printing is a valuable modality with broad clinical applications. Hip preservation surgery outcomes are dependent on correction of morphological abnormalities that may be optimally visualized with three-dimensional models. To assess the efficacy of three-dimensional models for patient and trainee education and to determine its benefits during pre-operative planning in hip preservation surgery. Sixteen patients with hip pathology were selected. Computed tomography was utilized to generate three-dimensional models. Customized Likert-style questionnaires were given to 10 hip preservation surgeons, 11 orthopedic surgery residents and 10 patients. All residents strongly agreed or agreed that the three-dimensional hip models helped them to understand patients’ pathology. All but one patient agreed that the models assisted in their understanding of the treatment plan. Surgeons concurred that although they do not routinely order three-dimensional models, their use would improve trainee and patient education, especially when treating atypical osseous pathomorphologies. Three-dimensional models are tools that can help surgeon, trainee and patient understanding and participation in treatment of complex hip disorders. Patients and trainees agree that the prototypes enhanced their educational experience, as the surgeon can directly demonstrate complex morphological abnormalities. Trainees can therefore gain a better understanding of hip pathologies and treatment. As patients better understand their hip disorder, they can more fully participate in shared treatment decision-making.

Level of Evidence
Level IV, Retrospective Case Series
An umbrella study of biomarker-driven targeted therapy in patients with platinum-resistant recurrent ovarian cancer: a Korean Gynecologic Oncology Group study (KGOG 3045), AMBITION
Authors: Lee Jung-Yun , Yi Ju Yeon , Kim Hyun-Soo , Lim June , Kim Sunghoon , Nam Byoung Ho , Kim Hee Seung , Kim Jae Weon , Choi Chel Hun , Kim Byoung-Gie ,   on behalf of KGOG investigators
Published: June 2019

Abstract
A pilot study of biomarker-driven targeted therapy in patients with platinum-resistant recurrent ovarian cancer has been started in Korea. Archival tumor samples were tested for HRD and PD-L1 status. Treatment arms will be allocated according to the test results. For HRD+ patients, we tested the synergistic effects of olaparib and other agents; treatment arms will randomly be allocated. (Arm 1: olaparib and cediranib; Arm 2: olaparib and durvalumab). For HRD- patients, we tested the role of biomarker-driven immunotherapy according to PD-L1 expression (Arm 3: durvalumab and chemotherapy in patients with high PD-L1 expression; Arm 4: durvalumab, tremelimumab, and chemotherapy in patients with low PD-L1 expression). Sixty-eight patients will be included from three Korean institutions within 1 year. The primary endpoint is the response rate according to RECIST 1.1 (6 months after treatment initiation). This trial has been registered with clinicaltrials.gov, and the registration number is NCT03699449.
Small mammal community composition varies among Ozark glades
Authors: Beasley Emily M , Maher Sean P 
Published: June 2019

Abstract
Island biogeography theory (IBT) explains and estimates large-scale ecological patterns among islands and isolated habitat patches. Specifically, IBT predicts that the number of species per habitat patch differs as a function of area and isolation as a result of local colonization and extinction. Accurate estimates of species richness are essential for testing predictions of IBT, but differences in detectability of species can lead to bias in empirical data. Hierarchical community models correct for imperfect detection by leveraging information from across the community to estimate species-specific occupancy and detection probabilities. Using the fragmented Ozark glades as our model system, we constructed a hierarchical community model to 1) estimate site-level and regional species richness of small mammals while correcting for detection error, and 2) determine environmental covariates driving occupancy. We sampled 16 glades in southwestern Missouri in summer 2016–2017 and quantified mammal community structure within the glade network. The detected species pool included eight species, and the model yielded a regional species estimate of 8.6 species, with a mean of 3.47 species per glade. Species richness increased with patch area but not isolation, and effects of patch shape varied between species in the community.
Intermediate-mass black hole growth and feedback in dwarf galaxies at high redshifts
Authors: Barai Paramita , de Gouveia Dal Pino Elisabete M 
Published: June 2019

Abstract
Intermediate-mass black holes (IMBHs; masses between $100\rm{\, and \,}10^{6} \, \mathrm{M}_{\odot }$) historically comprise of an elusive population compared to stellar-mass and supermassive black holes (BHs). Recently, IMBHs have started to be observed at the centres of low-mass galaxies. We perform cosmological hydrodynamical simulations of $(2 \, h^{-1} ~ {\rm Mpc})^3$ comoving boxes and investigate the growth and feedback of central IMBHs in dwarf galaxies (DGs). The earliest BHs appear at z ∼ 18–25 and grow thereafter by accreting gas and by merger with other BHs. We find that, starting from $10^{2} \, \mathrm{M}_{\odot }$, it is possible to build up IMBHs of a few$\times 10^{5}\!-\!10^{6} \, \mathrm{M}_{\odot }$ by z = 5, when the BHs are seeded in haloes less massive than $4 \times 10^{7} \, \mathrm{M}_{\odot }$. The BH accretion rates increase with time and reach $\dot{M}_{\rm BH} = (0.2\!-\!0.8) \dot{M}_{\rm Edd}$ for the massive IMBHs by z = 4. The star formation rate density (SFRD) evolution of the DGs (stellar mass $10^{5}\!-\!10^{8} \, \mathrm{M}_{\odot }$) has a peak plateau between z = 4 and 6. Star formation is quenched between z = 9 and 4. The SFRD is reduced by factors up to 3 when the BHs have grown to a few times $10^5 \, \mathrm{M}_{\odot }$. Even in the presence of stronger supernova (SN)-driven mass ejection, the BHs continue to grow up to z ∼ 6, sustained by gas inflows driven by galaxy mergers and interactions in a cosmological environment. Our conclusions, based on numerical simulation results, support the scenario that early feedback from IMBHs in gas-rich DGs at z = 5–8 can potentially solve several anomalies in the DG mass range within the concordance Λ cold dark matter (ΛCDM) cosmological scenario (Silk 2017). Our results suggest that IMBHs at DG centres grow faster than their host galaxies in the early Universe, and the resulting BH feedback turns the DGs and the BHs dormant.
Connecting galaxy structure and star formation: the role of environment in formation of S0 galaxies
Authors: Mishra Preetish K , Wadadekar Yogesh , Barway Sudhanshu 
Published: June 2019

Abstract
In this work, we investigate the reason behind the increased occurrence of S0 galaxies in high-density environments. Our sample comprises of ∼2500 spiral and ∼2000 S0 galaxies spanning a wide range of environments. Dividing the galaxies into categories of classical and pseudo-bulge hosting spiral and S0 galaxies, we have studied their properties as a function of the environment. We find that the fraction of pseudo-bulge hosting disc galaxies decreases with increase in density. The classical bulge hosting spirals and S0 galaxies follow a similar trend in less dense environments but towards higher densities, we observe an increase in the fraction of classical bulge host S0 galaxies at the expense of spirals. Comparing the structural and the star formation properties of galaxies on the size–mass and NUV − r colour–mass planes, respectively, we infer that classical bulge hosting spirals are likely to get transformed into S0 morphology. We notice a trend of galaxy structure with environment such that the fraction of classical bulge hosting spiral galaxies is found to increase with environment density. We also find that among classical bulge hosting spirals, the fraction of quenched galaxies increases in denser environments. We surmise that the existence of more classical bulge hosting spirals galaxies and more efficient quenching leads to the observed increased occurrence of S0 galaxies in high-density environments. The relation between galaxy structure and environment also exists for the disc galaxies irrespective of their visual morphology, which is driven mainly by halo mass.
Recombination-Aware Phylogenomics Reveals the Structured Genomic Landscape of Hybridizing Cat Species
Authors: Li Gang , Figueiró Henrique V , Eizirik Eduardo , Murphy William J 
Published: June 2019

AbstractCurrent phylogenomic approaches implicitly assume that the predominant phylogenetic signal within a genome reflects the true evolutionary history of organisms, without assessing the confounding effects of postspeciation gene flow that can produce a mosaic of phylogenetic signals that interact with recombinational variation. Here, we tested the validity of this assumption with a phylogenomic analysis of 27 species of the cat family, assessing local effects of recombination rate on species tree inference and divergence time estimation across their genomes. We found that the prevailing phylogenetic signal within the autosomes is not always representative of the most probable speciation history, due to ancient hybridization throughout felid evolution. Instead, phylogenetic signal was concentrated within regions of low recombination, and notably enriched within large X chromosome recombination cold spots that exhibited recurrent patterns of strong genetic differentiation and selective sweeps across mammalian orders. By contrast, regions of high recombination were enriched for signatures of ancient gene flow, and these sequences inflated crown-lineage divergence times by ∼40%. We conclude that existing phylogenomic approaches to infer the Tree of Life may be highly misleading without considering the genomic architecture of phylogenetic signal relative to recombination rate and its interplay with historical hybridization.
GITRL-armed Delta-24-RGD oncolytic adenovirus prolongs survival and induces anti-glioma immune memory
Authors: Rivera-Molina Yisel , Jiang Hong , Fueyo Juan , Nguyen Teresa , Shin Dong Ho , Youssef Gilbert , Fan Xuejun , Gumin Joy , Alonso Marta M , Phadnis Sheetal , Lang Frederick F , Gomez-Manzano Candelaria 
Published: June 2019

Abstract

Background
Viroimmunotherapy is evolving as a strong alternative for the standard treatment of malignant gliomas. Promising results from a recent clinical trial testing the anticancer effect of Delta-24-RGD in patients with glioblastoma suggested the induction of antitumoral immunity after viral administration. To further enhance the anti-glioma immune effect, we have armed Delta-24-RGD with the costimulatory ligand GITRL (Delta-24-GREAT [Glucocorticoid Receptor Enhanced Activity of T cells]).

Methods
We tested the infectivity and replication of Delta-24-GREAT, and the expression of ectopic GITRL in human and murine glioma cell lines. In vivo experiments involved the intracranial implantation of glioma cells into an immunocompetent model to study the anticancer effect, and rechallenging experiments to study long-term protection. Phenotypic and functional characterization of lymphocyte populations were performed by FACS and ELISA for Th1 cytokines expression, respectively.

Results
Our results showed that Delta-24-GREAT infects and induces the expression of GITRL. Delta-24-GREAT prolonged the survival of glioma-bearing immunocompetent mice and resulted in both anti-viral and anti-glioma immune responses, including increased frequency of central memory CD8+ T cells. Rechallenging the surviving mice with a second implantation of glioma cells did not lead to tumor growth; however, the surviving mice developed lethal tumors when B16/F10 melanoma cells were implanted intracranially, strongly indicating that the immune response was specific for glioma antigens.

Conclusions
GITRL-armed Delta-24-RGD treatment results in an antigen-restricted antitumor memory, an enhanced anti-glioma effect, and the generation of central immune memory. Our results strongly indicate that this strategy represents a vertical advance in virotherapy designed to treat patients with malignant brain tumors.
Interaction of polymorphisms in APOA4-APOA5-ZPR1-BUD13 gene cluster and sleep duration on 5-year lipid changes in middle aged and older Chinese
Authors: Yang Liangle , Ma Lin , Guo Wenting , Fang Qin , Lai Xuefeng , Zhang Xiaomin 
Published: June 2019

Abstract

Study Objectives
Lipid profiles are influenced by both genetic and environmental factors. Genetic variants in the APOA4-APOA5-ZPR1-BUD13 gene cluster and aberrant sleep duration were independently identified to be associated with lipids in previous studies. We aimed to investigate whether sleep duration modified the genetic associations with longitudinal lipids changes.

Methods
Four single nucleotide polymorphisms (SNPs), rs17119975, rs651821, rs7396835, and rs964184 in the APOA4-APOA5-ZPR1-BUD13 gene cluster were genotyped among 8648 apparently healthy subjects from the Dongfeng-Tongji (DFTJ) cohort. Information on sleep duration was obtained by questionnaires. Changes in total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), were evaluated from baseline to 5-year follow-up.

Results
After multivariate adjustments, we found that rs651821 and weighted genetic risk score (GRS) were significantly associated with increased triglyceride, and the genetic association with triglyceride change consistently strengthened across sleep duration categories. The differences in triglyceride changes per increment of risk allele for rs651821 were 0.028 (SE = 0.017, p = 0.112), 0.051 (SE = 0.009, p < 0.001), and 0.064 (SE = 0.016, p < 0.001) in individuals with sleep duration ≤7, >7–<9, and ≥9 h, respectively (p interaction = 0.031). The GRS also showed a significant interaction with sleep duration categories for triglyceride change (p interaction = 0.010). In addition, all of the four SNPs and GRS were inversely related to HDL-c changes.

Conclusions
Longer sleep duration might exacerbate the adverse effects of SNPs in APOA4-APOA5-ZPR1-BUD13 gene cluster on 5-year triglyceride changes.
Age and autonomic control, but not cerebral oxygenation, are significant determinants of EEG spectral power in children
Authors: Walter Lisa M , Tamanyan Knarik , Weichard Aidan J , Biggs Sarah N , Davey Margot J , Nixon Gillian M , Horne Rosemary S C 
Published: June 2019

AbstractStudy ObjectivesSleep disordered breathing (SDB) in children has significant effects on daytime functioning and cardiovascular control; attributed to sleep fragmentation and repetitive hypoxia. Associations between electroencephalograph (EEG) spectral power, autonomic cardiovascular control and cerebral oxygenation have been identified in adults with SDB. To date, there have been no studies in children. We aimed to assess associations between EEG spectral power and heart rate variability as a measure of autonomic control, with cerebral oxygenation in children with SDB.MethodsOne hundred sixteen children (3–12 years) with SDB and 42 controls underwent overnight polysomnography including measurement of cerebral oxygenation. Power spectral analysis of the EEG derived from C4-M1 and F4-M1, quantified delta, theta, alpha, and beta waveforms during sleep. Multiple regression tested whether age, SDB severity, heart rate (HR), HR variability (HRV), and cerebral oxygenation were determinants of EEG spectral power.ResultsThere were no differences in EEG spectral power derived from either central or frontal regions for any frequency between children with different severities of SDB so these were combined. Age, HR, and HRV low frequency power were significant determinants of EEG spectral power depending on brain region and sleep stage.ConclusionThe significant findings of this study were that age and autonomic control, rather than cerebral oxygenation and SDB severity, were predictive of EEG spectral power in children. Further research is needed to elucidate how the physiology that underlies the relationship between autonomic control and EEG impacts on the cardiovascular sequelae in children with SDB.
Sleep duration and fragmentation in relation to leukocyte DNA methylation in adolescents
Authors: Jansen Erica C , Dolinoy Dana C , O’Brien Louise M , Peterson Karen E , Chervin Ronald D , Banker Margaret , Téllez-Rojo Martha María , Cantoral Alejandra , Mercado-Garcia Adriana , Sanchez Brisa , Goodrich Jaclyn M 
Published: June 2019

Abstract

Study Objectives
Sleep deprivation and low sleep quality are widespread among adolescents, and associate with obesity risk. Plausible mediators include diet and physical activity. Another potential interrelated pathway, as yet unexplored in adolescents, could involve epigenetic modification of metabolism genes.

Methods
In a cohort of 351 Mexico City adolescents (47% male; mean [SD] age = 14 [2] years), 7-day actigraphy was used to assess average sleep duration, sleep fragmentation, and movement index. DNA isolated from blood leukocytes was bisulfite-converted, amplified, and pyrosequenced at four candidate regions. Linear mixed models evaluated sex-stratified associations between sleep characteristics (split into quartiles [Q]) and DNA methylation of each region, adjusted for potential confounders.

Results
Mean sleep duration was 8.5 [0.8] hours for boys and 8.7 [1] hours for girls. There were sex-specific associations between sleep duration and LINE-1 (long interspersed nuclear element) methylation. Boys with longer sleep duration (Q4) had lower LINE-1 methylation than boys in the 3rd quartile reference category, while girls with both longer and shorter sleep duration had higher LINE-1 methylation compared to Q3. Longer sleep duration was associated with higher H19 methylation among girls (comparing highest to third quartile, −0.9% [−2.2, 0.5]; p, trend = 0.047). Sleep fragmentation was inversely associated with peroxisome proliferator-activated receptor alpha (PPARA) methylation among girls (comparing highest to lowest fragmentation quartile, 0.9% [0.1 to 1.8]). Girls also showed an inverse association between sleep fragmentation and hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2; Q4 to Q1, 0.6% [−1.2%, 0%]).

Conclusions
Sleep duration and fragmentation in adolescents show sex-specific associations with leukocyte DNA methylation patterns of metabolism genes.
Old and Dangerous: Bordering Older Migrants’ Mobilities, Rejuvenating the Post-Welfare State
Authors: Braedley Susan , Côté-Boucher Karine , Przednowek Anna 
Published: June 2019

AbstractCaught in the cross-hairs of perceived crises of aging populations, increasing migration flows, and social welfare sustainability, older migrants are often not welcome in post-welfare states. Employing a feminist border analysis, Canada’s relatively generous immigration policies on parent and grandparent entry are analyzed to show the ways in which older people’s mobilities are bordered, who is most affected, and why this bordering is worthy of attention. We show links between these policies and Canada’s national rejuvenation project that aims to externalize and privatize both the costs and labor of social reproduction, limiting state contributions.
Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned With the Zebrafish Embryotoxicity Test
Authors: Stephens Martin L , Akgün-Ölmez Sevcan Gül , Hoffmann Sebastian , de Vries Rob , Flick Burkhard , Hartung Thomas , Lalu Manoj , Maertens Alexandra , Witters Hilda , Wright Robert , Tsaioun Katya 
Published: June 2019

AbstractSystematic review methodology is a means of addressing specific questions through structured, consistent, and transparent examinations of the relevant scientific evidence. This methodology has been used to advantage in clinical medicine, and is being adapted for use in other disciplines. Although some applications to toxicology have been explored, especially for hazard identification, the present preparatory study is, to our knowledge, the first attempt to adapt it to the assessment of toxicological test methods. As our test case, we chose the zebrafish embryotoxicity test (ZET) for developmental toxicity and its mammalian counterpart, the standard mammalian prenatal development toxicity study, focusing the review on how well the ZET predicts the presence or absence of chemical-induced prenatal developmental toxicity observed in mammalian studies. An interdisciplinary team prepared a systematic review protocol and adjusted it throughout this piloting phase, where needed. The final protocol was registered and will guide the main study (systematic review), which will execute the protocol to comprehensively answer the review question. The goal of this preparatory study was to translate systematic review methodology to the assessment of toxicological test method performance. Consequently, it focused on the methodological issues encountered, whereas the main study will report substantive findings. These relate to numerous systematic review steps, but primarily to searching and selecting the evidence. Applying the lessons learned to these challenges can improve not only our main study, but may also be helpful to others seeking to use systematic review methodology to compare toxicological test methods. We conclude with a series of recommendations that, if adopted, would help improve the quality of the published literature, and make conducting systematic reviews of toxicological studies faster and easier over time.
Using a Global Health Media Project Video to Increase Knowledge and Confidence in the Mothers of Admitted Neonates in Rwanda: A Prospective Interventional Study
Authors: Arinitwe Richard , Willson Alice , Batenhorst Sean , Cartledge Peter T 
Published: June 2019

Abstract

Introduction
In resource-limited settings, the ratio of trained health care professionals to admitted neonates is low. Parents therefore, frequently need to provide primary neonatal care. In order to do so safely, they require effective education and confidence. The evolution and availability of technology mean that video education is becoming more readily available in this setting.

Aim
This study aimed to investigate whether showing a short video on a specific neonatal topic could change the knowledge and confidence of mothers of admitted neonates.

Methods
A prospective interventional study was conducted in two hospitals in Kigali, Rwanda. Mothers of admitted neonates at a teaching hospital and a district hospital were invited to participate. Fifty-nine mothers met the inclusion criteria. Participants were shown ‘Increasing Your Milk Supply, for mothers’ a seven-minute Global Health Media Project video in the local language (Kinyarwanda). Before and after watching the video, mothers completed a Likert-based questionnaire which assessed confidence and knowledge on the subject.

Results
Composite Likert scores showed a statistically significant increase in knowledge (pre = 27.2, post = 33.2, p &lt; 0.001) and confidence (pre = 5.9, post = 14.2, p &lt; 0.001). Satisfaction levels were high regarding the video content, language and quality. However, only 10% of mothers owned a smartphone.

Discussion
We have shown that maternal confidence and knowledge on a specific neonatal topic can be increased through the use of a short video and these videos have the potential to improve the quality of care provided to admitted neonates by their parents in low-resource settings.