bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of the R3 Test-Based Reactivity of Supplementary Cementitious Materials: A Machine Learning Approach Utilizing Physical and Chemical Properties
Authors: Yoon Jinyoung , Yonis Aidarus , Park Sungwoo , Rajabipour Farshad , Pyo Sukhoon 
Published: November 2024

AbstractThis study utilized machine learning (ML) models to investigate the effect of physical and chemical properties on the reactivity of various supplementary cementitious materials (SCMs). Six SCMs, including ground granulated blast furnace slag (GGBFS), pulverized coal fly ash (FA), and ground bottom ash (BA), underwent thorough material characterization and reactivity tests, incorporating the modified strength activity index (ASTM C311) and the R3 (ASTM C1897) tests. A data set comprising 46 entries, derived from both experimental results and literature sources, was employed to train ML models, specifically artificial neural network (ANN), support vector machine (SVM), and random forest (RF). The results demonstrated the robustness of the ANN model, achieving superior prediction accuracy with a testing mean absolute error (MAE) of 9.6%, outperforming SVM and RF models. The study classified SCMs into reactivity classes based on correlation analysis, establishes a comprehensive database linking material properties to reactivity, and identifies key input parameters for predictive modeling. While most SCMs exhibited consistent predictions across types, GGBFS displayed significant variations, prompting a recommendation for the inclusion of additional input parameters, such as fineness, to enhance predictive accuracy. This research provided valuable insights into predicting SCM reactivity, emphasizing the potential of ML models for informed material selection and optimization in concrete applications.
Effects and interactions of dietary lysine and apparent nitrogen corrected metabolizable energy on yellow-feathered broiler breeder hens
Authors: Wang Yibing , Wang Qin , Yao Xiangtian , Gou Zhongyong , Lin Xiajing , Luo Qili , Jiang Shouqun 
Published: November 2024

Abstract
Background
Dietary lysine and apparent nitrogen-corrected metabolizable energy (AMEn) are two key variables affecting the production of breeder hens. In this study, the effects and interactions of lysine and AMEn on yellow-feathered broiler breeder hens were investigated. A total of 720 30-week-old breeder hens were fed in a 5 (lysine: 0.56%, 0.68%, 0.80%, 0.92%, and 1.04%) × 2 (AMEn: 11.50 and 11.10 MJ/kg) factorial arrangement for 12 weeks. The productive performance, reproductive traits, biochemical variables of breeder hens, the amino acid concentration and quality of eggs, and the growth performance of offspring broilers were determined.

Result
(1) Dietary lysine had quadratic effects (P < 0.05) on laying rate, average daily egg mass and feed intake/egg mass of breeder hens; birds with 11.50 MJ/kg AMEn (high AMEn) had higher (P < 0.05) BW than those with 11.10 MJ/kg AMEn (low AMEn); (2) dietary lysine significantly affected on the relative ovarian weight (quadratic and linear), and numbers of large yellow follicles (LYF, quadratic); birds with high AMEn had longer fallopian tube and more LYF than those with low AMEn (P < 0.05); (3) dietary lysine had significant effects (linear and quadratic) on eggshell thickness and shell strength of eggs from breeder hens; birds with high AMEn had thinner eggshells and deeper yolk color than those with low AMEn (P < 0.05); (4) there were higher (P < 0.05) contents of protein and concentrations of all measured animo acids (AAs) in eggs from birds fed low AMEn; (5) supplementation with high AMEn to breeder hens significantly increased the hatchability of fertilized eggs; (6) neither dietary lysine level or AMEn affected growth performance of offspring broilers; (7) both dietary lysine level and AMEn significantly affected gonadotropin concentrations and biochemical variables of breeder hens.

Conclusions
Dietary lysine had significant influences on productive performance, reproductive traits, and egg quality of yellow-feathered breeder hens. Based on productive performance, the optimal levels of dietary lysine were 0.81% to 0.83%, while 0.71% to 72% lysine was enough to obtain the best quality of breeding eggs. High AMEn was more beneficial to breeder hens for reproductive traits and hatchability of the fertilized eggs, while it showed detrimental effects on eggshell thickness and AA concentrations of breeding eggs.
Vertical targeting of the PI3K/AKT pathway at multiple points is synergistic and effective for non-Hodgkin lymphoma
Authors: Kupcova Kristyna , Senavova Jana , Jura Filip , Herman Vaclav , Rajmonova Anezka , Pacheco-Blanco Mariana , Chrbolkova Tereza , Hamova Iva , Davis R. Eric , Havranek Ondrej 
Published: November 2024

AbstractThe phosphatidylinositol 3‑kinase/protein kinase B (PI3K/AKT) signaling pathway is critically active in many cell types, both normal and neoplastic. Many small-molecule inhibitors targeting different levels of the PI3K/AKT pathway have been developed for cancer therapy, but their efficacy is reduced by compensatory pathway re-activation mechanisms, and their tolerability by toxic side effects. We studied this problem using cell lines representing diffuse large B-cell lymphoma (SUDHL-4 and OCI-Ly7), a genetically-encoded live-cell reporter of AKT activity, and 3 small-molecule inhibitors targeting different levels of the pathway: idelalisib (PI3Kδ), GSK2334470 (PDPK1), and ipatasertib (AKT). Half-maximal (IC50) concentrations of these inhibitors for AKT activity inhibition at 1 h, when used individually, were much lower than their IC50 values for reduction of viable cell number after 4 days. Time-course studies explained this discrepancy: AKT activity in the continuous presence of the inhibitors returned to normal after 24 h, and was supranormal after inhibitor removal. Combining all 3 inhibitors produced sustained inhibition of AKT activity, was broadly synergistic at reducing viable cell number, enabled substantially lower doses of each inhibitor to be used, and was enhanced further by the mTOR inhibitor rapamycin. Moreover, combined PDPK1 and AKT inhibition showed synergy with multiple different PI3K inhibitors. In a syngeneic mouse cell line model of lymphoma (A20), the triple combination showed antitumor activity and no evidence of toxicity. Our findings provide proof of concept suggesting further study of the safety and efficacy of low-dose multilevel PI3K/AKT pathway inhibition, for lymphoma and perhaps other cancers.
Rockery morphology based on quantitative analysis of shading
Authors: Wang Yuan , Pan Ben , Zhang Qingping 
Published: November 2024

Abstract
The rockeries of classical Chinese gardens are masterpieces of classical Chinese garden art and form a key element of garden heritage. Consequently, a quantitative study of “rockery shadows” is of considerable importance to the study of “rockery forms.” In this study, we selected the representative North Rockery in Zhanyuan Garden of Nanjing and Ruiyunfeng, Guanyunfeng, and Yulinglong as the objects of the study. This study aims to explore the shadow images of rockeries using image extraction and targeted quantitative analysis methods. Macroscopically, the overall shape of rockery shadows was described using fractal dimensions; microscopically, the aspect ratio, angle, and refinement indexes of each shadow based on each observation angle of the rockery were measured using the PAT-GEOM plug-in in ImageJ software. SPSS Statistics was used for the normal distribution test of the angular distribution data. Consequently, the shadow data of the North Rockery in Zhanyuan Garden and Ruiyunfeng, Guanyunfeng, and Yulinglong, respectively, were analyzed and compared, and four rockery-shadow laws were derived. Finally, the results were applied to the design of the rockery morphological translation based on quantitative analysis of the shadows. The approach presented here will enhance landscape design, support environmental planning, and preserve cultural heritage.
Transcriptomics-guided optimization of vitamins to enhance erythromycin yield in saccharopolyspora erythraea
Authors: Ke Xiang , Jiang Xing , Wang Shuohan , Tian Xiwei , Chu Ju 
Published: November 2024

AbstractComparative transcriptomics uncovered distinct expression patterns of genes associated with cofactor and vitamin metabolism in the high-yielding mutant strain Saccharopolyspora erythraea HL3168 E3, as compared to the wild-type NRRL 2338. An in-depth analysis was conducted on the effects of nine vitamins, and it was determined that thiamine pyrophosphate (TPP), vitamin B2, vitamin B6, vitamin B9, vitamin B12, and hemin are key enhancers in erythromycin production in E3, increasing the erythromycin titer by 7.96–12.66%. Then, the Plackett-Burman design and the path of steepest ascent were applied to further optimize the vitamin combination for maximum production efficiency, enhancing the erythromycin titer in shake flasks by 39.2%. Otherwise, targeted metabolomics and metabolic flux analysis illuminated how vitamin supplementation modulates the central carbon metabolism with notable effects on the TCA cycle and methionine synthesis to augment the provision of energy and precursors essential for erythromycin synthesis. This work highlights the capacity for precise vitamin supplementation to refine metabolic pathways, thereby boosting erythromycin production, and provides valuable directions for application on an industrial scale.
Graphical Abstract
A review of the application of in-vivo confocal microscopy on conjunctival diseases
Authors: Yu Mingyi , Liu Chang , Mehta Jodhbir S. , Liu Yu-Chi 
Published: November 2024

AbstractOver the past few decades, the expanded applications of in-vivo confocal microscopy (IVCM) have greatly enhanced the knowledge of a variety of conjunctival diseases. IVCM allows non-invasively detailed observation of tarsal, palpebral and bulbar conjunctiva, from the superficial to the substantia propria at the cellular level. IVCM has been shown as a powerful tool for the assessment of morphological changes in both physiological and pathological conditions. High-resolution images of different cellular phenotypes, together with quantifiable results, open new insights into understanding the mechanisms of conjunctival diseases, as well as provide valuable and longitudinal information for the diagnosis and therapeutic evaluation. This review aims to provide an overview of the current knowledge on the applications of IVCM on conjunctival disorders, including aging changes, dry eye-related morphological changes, glaucoma and glaucoma surgery-related morphological changes, conjunctival neoplasm, pterygium, allergic conjunctivitis, trachomatous scarring, and the conjunctiva-associated lymphoid tissue (CALT) changes. In this review, we highlight the key findings of previous studies and discusses the current limitations and challenges of IVCM in assessing the structural characteristics of the conjunctiva. Furthermore, we consider possible future directions for unlocking the full potential of IVCM applications. The insights presented here will contribute to a more comprehensive understanding of the applications of IVCM in conjunctival diseases.
Development and feasibility of a sex- and gender-sensitive primary care intervention for patients with chronic non-cancer pain receiving long-term opioid therapy (GESCO): a study protocol
Authors: Kersting Christine , Just Johannes , Piotrowski Alexandra , Schmidt Alexandra , Kufeld Neele , Bisplinghoff Rebecca , Maas Michaela , Bencheva Veronika , Preuß Jordan , Wiese Birgitt , Weckbecker Klaus , Mortsiefer Achim , Thürmann Petra ,   on behalf of the GESCO study group, Duck Michaela , Schmiedl Sven , Bahrs Ottomar , Cegla Thomas , Elsenbruch Sigrid , Levenig Claudia , Hunger-Schoppe Christina , Kiessling Claudia , Klee Ulrich , Lauf Ursula , Scholz Brigitte , Moser Albine , Scherbaum Norbert , Specka Michael 
Published: November 2024

Abstract
Background
Chronic non-cancer pain (CNCP) is a common condition worldwide. The disease burden is influenced not only by pain itself, but also by psychiatric co-morbidities, which aggravate symptoms, generally negatively influence therapies, and may thereby lead to frustration, resignation, or withdrawal. A growing body of evidence suggests that sex and gender aspects influence CNCP management as the experience of pain, the emotions associated with it, and the expression of pain may differ between women and men. In addition, doctor-patient communication is known to be influenced by gender stereotypes. Despite there being evidence on such differences, current guidelines do not consider sex- and gender-sensitive approaches. In order to examine how to adequately address the diversity of the experience and processing of pain in patients of differing sex and gender, the GESCO study aims at developing and pilot testing a sex- and gender-sensitive intervention for patients with CNCP receiving long-term opioid therapy (LTOT) in primary care.

Methods
The development process is designed in accordance with the first two phases of the UK Medical Research Council. Phase I will iteratively explore, develop, and pilot the intervention’s modules using literature searches, interviews, and workshops involving stakeholders and experts. Phase II will pilot-test the novel intervention in a sample of 40 patients with CNCP under LTOT from ten general practices using an effectiveness-implementation hybrid design including a mixed-methods process evaluation focusing on implementation strategy criteria and a single-arm, pre-post comparison to determine preliminary effects in preparation for a larger effectiveness trial. The intervention will combine in-person educational sessions for general practitioners and tools to be used in patient care.

Discussion
The intervention aims to improve CNCP management in primary care by empowering practitioners to reflect on their attitudes towards pain and stereotypes. Besides sex and gender aspects, awareness of other factors that might affect the care process, such as age, social conditions, or culture, is also promoted. The intention is to develop a comprehensive care concept for CNCP that considers aspects relevant for sex- and gender-sensitive care which are transferrable to other health care fields as well.

Trial registration
German Clinical Trial Register DRKS00029980.
The financial benefits of health engagement programs to life insurers
Authors: Lee Hae Kang 
Published: November 2024

AbstractLife insurance companies, as equity stakeholders in policyholders’ lives, have incentives to mitigate their health risks. I introduce a framework that enables life insurers to evaluate the financial viability of developing and implementing health engagement programs. By leveraging a proprietary big database of health and mortality information from a large U.S. life insurer, I use machine learning techniques to quantify the benefits and use a rational addiction model to calculate the costs associated with these programs. The estimated net benefit available to the life insurer from the smoking cessation program is USD 87 million and the aggregate benefit from including other chronic conditions is USD 872 million. I explore the broader application of this framework in a general health policy context.
Investigating differentiated instruction and the contributing factors to cater EFL students’ needs at the collegial level
Authors: Tajik Omid , Noor Shagofah , Golzar Jawad 
Published: November 2024

AbstractTeaching language has challenges for many reasons, including learners’ backgrounds, learning styles, motivation, and socio-economic status. However, EFL students can benefit from differentiation across the learning continuum to a large extent. This study investigated Afghan EFL learners’ perceptions of differentiated instruction and the factors that contributed to catering to their needs. This study revolved around five main elements of differentiated instruction: learning environment, content, process, product, and assessment. In this study, a questionnaire was developed and distributed to 102 EFL students at Herat University, Afghanistan, to record their perceptions of differentiated instruction in their classes. Three teachers of the English department at the same university were also interviewed to understand their experiences implementing differentiated instruction and identify their tensions. Data from the survey and interviews highlight that while DI requires significant teacher commitment and time, properly designed classes catering to learner specifics can enhance efficiency and be reused in future heterogeneous settings. The study’s results suggested that it is practical to implement differentiated instruction in mixed-level, large, heterogeneous classrooms.
Amlodipine increases risk of primary open-angle glaucoma
Authors: Lehrer Steven , Rheinstein Peter H. 
Published: November 2024

Abstract
Background
The use of calcium channel blockers is associated with primary open-angle glaucoma (POAG) in a statistically meaningful but minor way. In general, those who had received calcium channel blocker medication were at a 23% increased risk of developing glaucoma in comparison to those who had never taken the antihypertensive drugs. We wished to confirm this association and examine POAG genes that might be involved, since the genetics has not yet been analyzed.

Methods
We used MedWatch and UK Biobank data to evaluate the effects of amlodipine on POAG and intraocular pressure (IOP). We analyzed three POAG-associated single-nucleotide polymorphisms: rs9913911, an intron variant in growth arrest-specific 7 (GAS7), one of the genes that influences IOP; rs944801, an intron variant within CDKN2B-AS1, and rs2093210, an intron variant within SIX6, known to be associated with vertical cup-disc ratio, an important optic nerve head parameter that is often used to define or diagnose glaucoma.

Results
Amlodipine use in MedWatch doubled the prevalence of POAG, from 0.0805 to 0.177%, a small but significant increase. Multivariate analysis by logistic regression of UK Biobank data revealed that POAG risk was significantly increased with age, male sex, major alleles of rs9913911 (GAS7) and rs944801 (CDKN2B-AS1), and minor allele of rs2093210 (SIX6). Amlodipine increased POAG risk by 16.1% (P = 0.032). Amlodipine has not been associated with increased IOP. We confirmed this lack of association and in addition found that GAS7, associated with IOP, was not associated with POAG risk and amlodipine. But CDKN2B-AS1 and SIX6, POAG genes not associated with IOP, were associated with POAG and amlodipine.

Conclusions
Amlodipine, a frequently prescribed drug and first line treatment for hypertension, has a potentially hazardous relationship with POAG. Knowledge of this link can guide the prescribing of alternate drugs for hypertensive individuals who have glaucoma or are at risk for it. Diuretics and β-blockers are not associated with POAG or increased IOP and could be substituted for amlodipine in hypertensive patients at risk POAG.

Trial registration
None.

Graphical Abstract
Assessing pain management in total joint arthroplasty using the Detroit interventional pain assessment scale—A prospective cohort study
Authors: Boggs Lauryn J. , Patel Ishan , Holyszko Melina , Little Bryan E. , Darwiche Hussein F. , Vaidya Rahul 
Published: November 2024

Abstract
Background
Total joint arthroplasty (TJA) is an effective treatment for end-stage osteoarthritis, but postoperative pain has been poorly managed. The purpose of this study was to (1) assess how much narcotic medication was prescribed after TJA; (2) assess if patients were satisfied with their pain management; (3) compare these same data between total hip arthroplasty (THA)/total knee arthroplasty (TKA); (4) compare these same data between preoperative opioid users/opioid-naïve patients.

Methods
An IRB-approved prospective study was conducted at a US academic joint replacement practice. Patients were evaluated by an independent observer at three weeks, three months, and six months postoperatively using the Detroit Interventional Pain Assessment (DIPA) scale. Patients verbally rated their pain with their current medication regimen as 0 (no pain), 1 (tolerable pain), or 2 (intolerable pain) on the DIPA scale. Narcotic usage was verified by the Michigan Automated Prescription System (MAPS). Patients were divided into THA, TKA, previously on opioids, and opioid-naïve groups. Provider efficiency scores reflected pain management satisfaction and were calculated as the percentage of patients reporting no pain or tolerable pain.

Results
Out of 200 patients, the percentage of patients using narcotics and their daily usage (MMEs) significantly decreased from 75.5% (27.5 MMEs) at three weeks to 42.9% (5.3 MMEs) at six months (P < 0.001). In 80% of patients, narcotics taken at six months were prescribed by outside providers. Significantly fewer patients used narcotics at six months for THA (15.4%) compared to TKA (52.7%) (P < 0.021). There was a significant difference in daily narcotic usage between patients who took narcotics preoperatively (22.9 MMEs) and opioid-naïve ones (13.4 MMEs) (P < 0.001). Provider efficiency scores were best at three weeks (76.6%) and three months (70%) but declined at six months (57.2%).

Conclusions
Narcotic tapering practices were observed as postoperative daily narcotic intake decreased across six months. However, outside providers prescribed 80% of narcotics at six months, necessitating a better-coordinated practice with surgeons. Patients taking preoperative narcotics experienced higher daily MME requirements than their opioid-naïve counterparts. In terms of the percentage of patients on narcotics, THA is a better procedure for tapering patients off narcotics by six months.
Business research on Industry 4.0: a systematic review using topic modelling approach
Authors: Islam Md Nazrul , Hossain Md Mofazzal , Ornob Md Shafayet Shahed 
Published: November 2024

AbstractThe number of theoretical and empirical literature on Industry 4.0 research has seen tremendous growth over the past few years. We seek to identify and classify the popular research topics published on Industry 4.0 in business and economics literature using a novel approach. First, we performed a co-occurrence analysis and found Industry 4.0 to have the strongest connection with innovation, implying the indispensability of innovation for the fourth industrial revolution. Further, we employed LDA-based topic modelling to identify the most frequent terms and labelled eight different topics based on the quantitative value of each term. Finally, we reviewed the relevant literature for each topic identified through the topic modelling process. Our literature review reveals that the concentration of existing literature is model-focussed. This study provides quantitative evidence of frequent occurrences of popular terms. We conclude that future studies should focus more on empirical measurement of the benefits of transiting towards the fourth industrial revolution.