bluuebunny/crossref_metadata_2025_split huggingface dataset:
Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritis
Authors: Varela-Eirín Marta , Varela-Vázquez Adrián , Paíno Carlos Luis , Casado-Díaz Antonio , Continente Alfonso Calañas , Mato Virginia , Fonseca Eduardo , Kandouz Mustapha , Blanco Alfonso , Caeiro José Ramón , Mayán María D. 
Published: June 2019

AbstractOsteoarthritis (OA) is the most prevalent disorder of articulating joints and a leading cause of disability in humans, affecting half of the world’s population aged 65 years or older. Articular cartilage and synovial tissue from OA patients show an overactivity of the membrane channel protein connexin43 (Cx43) and accumulation of senescent cells associated with disrupted tissue regeneration. We have recently demonstrated the use of the Cx43 as an appropriate therapeutic target to halt OA progression by decreasing the accumulation of senescent cells and by triggering redifferentiation of osteoarthritic chondrocytes (OACs) into a more differentiated state, restoring the fully mature phenotype and cartilage regeneration. In this study we have found that small molecular polyphenols derived by olive extracts target Cx43 and senescence in OACs, synovial and bone cells from patients and in human mesenchymal stem cells (hMSCs). Our results indicate that these small molecules including oleuropein regulate the promoter activity of Cx43 gene. The downregulation of Cx43 expression by oleuropein reduce gap junction intercellular communication, cellular senescence in chondrocytes and enhance the propensity of hMSCs to differentiate into chondrocytes and bone cells, reducing adipogenesis. In concordance with these results, these small molecules reduce Cx43 and decrease Twist-1 activity leading to redifferentiation of OACs, which restores the synthesis of cartilage ECM components (Col2A1 and proteoglycans) and reduces inflammatory and catabolic factors IL-1β, IL-6, COX-2 and MMP-3 and cellular senescence orchestrated by p53/p21 together with the synthesis of SASP via NF-kB. Altogether, our results demonstrate the use of the olive-derived polyphenols such as oleuropein as potentially effective therapeutic agents to enhance the efficacy of hMSC therapy and to induce a pro-regenerative environment in OA patients by restoring cellular phenotype and clearing out senescent cells in joint tissues in order to stop or prevent the progression of the disease.
Do extra ingredients on the package lead to extra calorie estimates?
Authors: Zhu Guowei , Chryssochoidis George , Zhou Li 
Published: June 2019

Purpose
This paper aims to address how adding food ingredients to a packaged base food affects consumers’ calorie estimation of the new augmented product.

Design/methodology/approach
The four performed experiments and analyses of variance demonstrate an underlying psychological mechanism, explained below.

Findings
Results show that the healthiness of the added food ingredient (AFI) does not matter if the base food is healthy, and consumers’ calorie estimates of the augmented packaged food product are accurate. When, however, the food base is unhealthy, and the AFI is healthy, consumers underestimate the new product calories. This underestimation effect increases further when the healthy ingredients multiply. This underestimation effect endures when these ingredients are presented in a visual form, but it becomes smaller when these ingredients are presented in a verbal form. A justification mechanism is relevant.

Research limitations/implications
Further research should test across the broader range of the food product matrix. There is a great diversity of AFI presentations, and further research may deal with the impact of AFIs of these different forms on consumers’ calorie estimation and healthiness perceptions. Research may also test sensory-arousing mechanisms that can help understand how consumers perceive the calories of the augmented food.

Practical implications
The findings suggest that consumers should be cautious of the judgment bias caused by the presence of an AFI on food packages and raise their awareness regarding nutrition implications and dietary effects. From the perspective of food manufacturers, although adding healthy AFIs to unhealthy base foods may increase consumers’ purchase intention and bring higher profits, it may not be sustainable as a marketing strategy in the long term and has immediate ethical implications.

Social implications
Policymakers should introduce voluntary schemes to monitor and restrict the improper presentation of AFIs, aiming to rule out the abuse of healthy AFIs on unhealthy packaged food.

Originality/value
This work offers three major original and valuable contributions. It explains the effects of AFIs on calorie estimation and consumer healthiness perceptions in a context not studied before, namely, packaged food products. Next, it advances the literature on consumer judgment error and heuristics concerning product package attributes. As adding ingredients is integral to product line extension decisions, the results also clarify how marketing can safeguard firm social responsibility in combating obesity.
Different strokes for different folks
Authors: Bijedić Teita , Piper Alan 
Published: June 2019

Purpose
Migrant enterprises comprise about 10 per cent of all enterprises in Germany and are therefore a crucial part of the German economy and its entrepreneurial ecosystems. Relatedly, migrant entrepreneurship is a highly recognized topic within political discussions as well as within entrepreneurship research. While there is already an impressive body of work regarding the nature and quality of migrant enterprises, many questions regarding the personal motives and satisfaction of migrant entrepreneurs still remain unanswered, particularly with regards to their job satisfaction. Thus, this study aims to address such questions regarding the job satisfaction of entrepreneurs with different backgrounds.

Design/methodology/approach
Using the German Socio-Economic Panel data set, the authors close this research gap by investigating the job satisfaction of migrant entrepreneurs in Germany compared with native entrepreneurs.

Findings
First generation migrants show, in general, less job satisfaction than the native population. Second generation male migrant entrepreneurs’ show less job satisfaction; however, this association is reversed for females: second generation female migrant entrepreneurs are more satisfied with their self-employment than their native counterparts.

Originality/value
These differing results lead to differing implications for policymakers who wish to create and develop entrepreneurial and labour market support for different target groups.
Student perceptions and trust of sustainability information
Authors: Hay Rachel , Eagle Lynne , Saleem Muhammad Abid , Vandommele Lisa , Li Siqiwen 
Published: June 2019

PurposeThe purpose of this paper is to report student attitudes and beliefs towards climate change adaptation and sustainability-related behaviours.Design/methodology/approachA paper-based questionnaire was completed by 247 first-year (students in their first semester of study) and third-year (students in their final semester of study) students in the same year (2012) of the study (Table I). A factor analysis shows that common themes previously identified failed to reflect the diverse range of influences on young people, including family, friends and news media.FindingsContrary to the literature, few significant differences were found in sustainability-related behaviours between first- and third-semester students, with an increase in scepticism regarding the reality of climate change among the latter.Research limitations/implicationsThe study focused on Australian undergraduate university business students. As a single-institution case study, the results may not be generalised to all university students. As such the authors recommended that the study be completed in other universities from around the world. The study was undertaken over one year, but the participants may not have necessarily been the same students in third semester as they were in first semester. Therefore, it is recommended that the study be repeated in future years so that the same cohort can be measured over time, providing a more accurate account of the development of student knowledge and perceptions of sustainability during their time at university.Practical implicationsAchieving significant long-term changes in behaviours will be a substantial challenge for tertiary curricula. The findings of this study can inform instructors in higher education of student attitudes towards sustainability and climate change adaption and in turn inform changes to tertiary curriculum in sustainability and climate change adaption.Originality/valueThis paper reports on the second phase of a longitudinal research project examining the effects of an undergraduate business studies curriculum on student views of sustainability. The authors confirm that the research is original and that all of the data provided in the study are real and authentic. Neither the entire work nor any of its parts have been previously published.
Enrollment management analytics: a practical framework
Authors: Delcoure Natalya , Carmona Jesus S. 
Published: June 2019

Purpose
The purpose of this paper is to examine the role of data analytics in addressing contemporary challenges and opportunities facing institutions of higher education, with a special emphasis on enrollment management for the example of a college of business administration in a Hispanic-serving four-year institution of higher education.

Design/methodology/approach
After reviewing previous research on this subject, the authors propose adding a new stratum to higher education analytics, enrollment management analytics, which uniquely identifies the actions associated with attracting and recruiting students, accounts for institutional differences and leads to students’ successful matriculation at institutions.

Findings
The authors demonstrate on the example of a professional college in a four-year institution of higher education how the utilization of modern analytical tools and techniques develop actionable decisions in the students’ recruitment process, which leads to their matriculation.

Originality/value
A definition and a new stratum in higher education analytics are proposed for enrollment management analytics.
Citizen participation in crime prevention: a study in Kuching, Sarawak, Malaysia
Authors: Lau Pang Heng , Ali Kamsiah 
Published: June 2019

Purpose
The purpose of this paper is to discuss citizen participation in crime prevention in Kuching, Malaysia. This is a study of how citizen participated in crime prevention has helped in crime reduction in Kuching. Roles of citizen in crime prevention with the police have been included in this study. Result showed that citizen and police joint crime prevention has succeeded in crime reduction in Kuching.

Design/methodology/approach
Three methods of data collection were used in this research study: first, face-to-face interviews of 500 head of households in Kuching. They are selected using systematic sampling among the 159,000 households in Kuching. Second, in-depth interviews of 36 respondents involving community leaders and crime watch groups; and third, secondary crime statistics from the Royal Malaysia Police. It is based on actual crime reported to the police.

Findings
Police and citizen involvement in crime prevention are effective in reducing crime. Citizen participation in crime prevention was 80.6 per cent. The higher the frequency police and citizen involvement in crime prevention patrols, the lesser the level of crime. With increased joint patrol by police and citizen in the neighbourhood, the level of crime will be lower, and safety will improve, and this is particular valid in the case of the nine geographical areas covered under Kuching police district.

Research limitations/implications
This study focused on citizen participation in crime prevention in Kuching police district only.

Practical implications
Police and citizen participation in crime prevention play a key role in crime reduction. This study argued that police and citizen frequent patrol will improve safety in the community. Training plays a key role for citizen to participate in crime prevention. Joint crime prevention patrol calls for a new breed of police officers who can work with the citizens. In return, the citizens trust the police to lead them in crime prevention.

Social implications
With citizen participation in crime prevention, the community will be safer, peaceful resulting in less crime. Citizens acted as an eye and ear to the police. As and when a citizen see a suspicious person in the neighbourhood, he informs the police. When the police arrives, the suspicious person who may have a criminal intent will either be arrested by the police or escaped before the police arrived.

Originality/value
This paper provides an insight into crime prevention exercise involving the citizens. The same concept can be implemented throughout Malaysia. Police needs to involve citizens always in crime prevention. Police and the community are one big family.
From expatriation to global migration
Authors: Latukha Marina , Soyiri Joseph , Shagalkina Mariia , Rysakova Liana 
Published: June 2019

PurposeThe purpose of this paper is twofold. First, the authors aim to examine the role of talent management (TM) practices in talent migration from developed countries to Ghana that may enhance country’s economic development through knowledge transfer. The paper also investigates the determinants of migration to the African countries.Design/methodology/approachDiscussing the importance of self-initiated expatriates (SIEs), and how TM practices may contribute to global migration, the authors develop a set of propositions and build a theoretical framework showing how firms from Ghana can push SIEs to a longer stay in Ghana stimulating inward migration by implementing TM practices.FindingsThe authors claim that in the Ghanaian context expatriates may become migrants by overcoming negative perceptions about Ghana as a destination. Besides the authors argue that talent attraction and talent retention practices with governmental support, play an important role in inward migration to Ghana.Research limitations/implicationsNew agenda for talent managers in Africa, namely addressing the possibilities for expatriates’ retention by developing and implementing TM practices to ensure knowledge transferring from developed countries is suggested.Originality/valueThe theoretical framework provides a useful starting point for explaining the interconnections of TM and the conversion from expatriation to the global migration phenomena by African countries that broaden the TM scope beyond individual and organizational aspects. The authors state that TM systems take on the principal role of addressing talent migration especially in the African context and are capable of converting expatriates, specifically SIEs, into migrants to solve important tasks related to knowledge attraction to developing countries.
Analyzing the influence of employee values on knowledge management in sport organizations
Authors: Delshab Vahid , Winand Mathieu , Sadeghi Boroujerdi Saeed , Pyun Do Young , Mahmoudian Abed 
Published: June 2019

Purpose
The purpose of this study is to investigate the relationship between employee values and knowledge management (KM) in sport organizations.

Design/methodology/approach
Data (N = 234) were collected online through a structured questionnaire from employees of 33 sport organizations in Iran. To test the hypotheses, Pearson correlation test and a regression analysis was conducted.

Findings
The results from the study revealed that there were significant relationships between employee values and KM. Both instrumental and terminal values significantly influenced KM.

Research limitations/implications
One limitation of this study is related to the generalizability of the results. Therefore, the current study is required to be replicated with other sport organizations in various sectors (public or private) to improve external validity of the results.

Practical implications
Based on this study, employees of sport organizations in developing countries tend to store knowledge more than sharing and applying it. The findings can be used by human resources and KM practitioners who are interested in developing organizational knowledge through employees’ values.

Originality/value
Through this study, the positive roles of employee instrumental and terminal values, as the key drivers in determining intangible assets in organizations, were found.
Designing smelter industry investment competitiveness policy in Indonesia through system dynamics model
Authors: Hanafi Muhammad , Wibisono Dermawan , Mangkusubroto Kuntoro , Siallagan Manahan , Badriyah Mila Jamilah Khatun 
Published: June 2019

PurposeThis research aims to examine the smelter industry’s investment competitiveness in Indonesia as well as to find solutions to improve its competitive advantage for the nation.Design/methodology/approachThis research applies a sequential mixed-methods approach with a second quantitative phase building on an initial first qualitative phase. The qualitative phase is conducted by interviews to find the root causes of problems as well as solutions to gain smelter industries’ competitiveness. The quantitative phase is conducted by a system dynamics model. A descriptive causal loop diagram is created based on interviews and focus group discussions to describe the problems. The concept of competitive advantage of a nation from Porter’s diamond model is applied in this research.FindingsThe results reveal the complexity of smelter industries in Indonesia. The paper also addresses the causes of problems and interaction of variables using a causal loop diagram. To gain the smelter industry’s competitiveness, this paper suggests the potential policy development to increase competitiveness of the smelter industry such as policy for different fiscal incentives to each different mineral, effective export duty and exploration obligation.Practical implicationsThe result of this study provides a good basis for government in making policy to improve the competitive advantage of the smelter industry investment in Indonesia.Originality/valueThis is the first research on smelter industry competitiveness that applies Porter’s diamond model and system dynamics model to find solutions in designing appropriate policy to gain competitiveness.
Ready and willing to learn: exploring personal antecedents to taking on learning challenges
Authors: Rigolizzo Michele 
Published: June 2019

Purpose
The purpose of this paper is to examine the personal antecedents to taking on the challenge of learning, particularly when there is competition for time at work. Taking on challenging tasks, particularly those that enhance learning, is a critical behavior in today’s dynamic business environments. This paper explores how individual differences motivate people to choose a challenging task over an easy one.

Design/methodology/approach
A behavioral measure was used to determine if working adults higher in learning goal orientation, curiosity, and need for cognition were more likely to take on a challenging task, even when there was competition for their time. Structural equation modeling was used to more deeply examine whether these constructs independently contribute to the outcome.

Findings
Goal orientation, curiosity and need for cognition each significantly predicted whether working adults took on a challenging task. Additional analysis revealed that learning goal orientation, curiosity, and need for cognition loaded onto a single factor.

Research limitations/implications
This paper answers calls for the use of direct measurement in social science research. Rather than asking individuals about what they have done or would do, the study observes what choices working adults actually make when confronted with the opportunity to learn.

Originality/value
Contributing to the recent surge of work on informal learning behaviors, this paper examines a critical learning behavior – that of taking on challenging tasks. It demonstrates that even if individuals are ready learn (have the time and resources), there are key individual differences that drive whether they are willing to do so.
A study on anticorrosive property of phenolic components from Pachysandra terminalis against low carbon steel corrosion in acidic medium
Authors: Chitra Subramanian , Chung Ill-Min , Kim Seung-Hyun , Prabakaran Mayakrishnan 
Published: June 2019

Purpose
The study aims to find new anticorrosive components from a plant source, namely, Pachysandra terminalis Sieb. et Zucc. (P. terminalis), a traditional medicinal shrub predominantly used by Tujia people.

Design/methodology/approach
Because phenolic components from plants are known for its numerous values in several fields, the corrosion inhibitive ability of P. terminalis extract was analyzed by electrochemical studies (polarization, electrochemical impedance spectroscopy) and surface examination (by scanning electron microscopy [SEM], energy-dispersive X-ray spectroscopy [EDX] and atomic force microscopy [AFM]).

Findings
The examination of total phenolic content (TPC), total flavonoids content (TFC) and individual phenols (UHPLC) showed the presence of 85.21 mg/g (TPC), 25.38 mg/g (TFC), protocatechuic acid (62.10 µg/g), gentisic acid (60.21µg/g), rutin (50.12 µg/g), kaempferol (46.58 µg/g) and p-Coumaric acid (42.35µg/g) . The polarization study shows that the maximum shift is (16 mV), imposing a mixed mode of inhibition, dominantly anodic. The surface morphology studies by SEM, EDX and AFM confirmed the adsorption of phytochemical components on the low carbon steel surface blocking the active sites.

Originality/value
The study unveils the inhibitive nature of P. terminalis, preventing aggressive attack by 0.5 M HCl on low carbon steel. This also exhibits few phenols present in methanolic leaf extract which may be the role player of corrosion inhibition.