bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can We Use the Intrinsic Left Ventricular Delay (QLV) to Optimize the Pacing Configuration for Cardiac Resynchronization Therapy With a Quadripolar Left Ventricular Lead?
Authors: van Everdingen Wouter M. , Zweerink Alwin , Cramer Maarten J. , Doevendans Pieter A. , Nguyên Uyên Châu , van Rossum Albert C. , Prinzen Frits W. , Vernooy Kevin , Allaart Cornelis P. , Meine Mathias 
Published: March 2018

Background:
Previous studies indicated the importance of the intrinsic left ventricular (LV) electric delay (QLV) for optimal benefit to cardiac resynchronization therapy. We investigated the use of QLV for achieving optimal acute hemodynamic response to cardiac resynchronization therapy with a quadripolar LV lead.

Methods and Results:

Forty-eight heart failure patients with a left bundle branch block were prospectively enrolled (31 men; age, 66±10 years; LV ejection fraction, 28±8%; QRS duration, 176±14 ms). Immediately after cardiac resynchronization therapy implantation, invasive LV pressure–volume loops were recorded during biventricular pacing with each separate electrode at 4 atrioventricular delays. Acute cardiac resynchronization therapy response, measured as change in stroke work (Δ%SW) compared with intrinsic conduction, was related to intrinsic interval between Q on the ECG and LV sensing delay (QLV), normalized for QRS duration (QLV/QRSd), and electrode position. QLV/QRSd was 84±9% and variation between the 4 electrodes 9±5%. Δ%SW was 89±64% and varied by 39±36% between the electrodes. In univariate analysis, an anterolateral or lateral electrode position and a high QLV/QRSd had a significant association with a large Δ%SW (all
P
<0.01). In a combined model, only QLV/QRSd remained significantly associated with Δ%SW (
P
<0.05). However, a direct relation between QLV/QRSd and Δ%SW was only seen in 24 patients, whereas 24 patients showed an inverse relation.

Conclusions:
The large variation in acute hemodynamic response indicates that the choice of the stimulated electrode on a quadripolar lead is important. Although QLV/QRSd was associated with acute hemodynamic response at group level, it cannot be used to select the optimal electrode in the individual patient.
Outcomes in Patients With Hypertrophic Cardiomyopathy Awaiting Heart Transplantation
Authors: Zuñiga Cisneros Julio , Stehlik Josef , Selzman Craig H. , Drakos Stavros G. , McKellar Stephen H. , Wever-Pinzon Omar 
Published: March 2018

Background:
Current organ allocation policy and the rapid growth of mechanical support favor heart transplant (HT) candidates on left ventricular assist devices. HT candidates with hypertrophic cardiomyopathy (HCM) are usually not left ventricular assist device candidates and may have a disadvantage compared with dilated forms of cardiomyopathy.

Methods and Results:

Adult HT candidates registered in the Scientific Registry of Transplant Recipients database between 1999 and 2016 were included. HCM candidates were compared with ischemic cardiomyopathy (ICM) and non-ICM patients. Two eras were defined on the basis of the approval date of the first continuous-flow left ventricular assist device for bridge-to-transplant in the United States (2008). Patients outcomes were evaluated while on the waitlist and after HT. The proportion of patients with HCM listed for HT increased by 44% in era 2 compared with era 1. Waitlist mortality in patients with ICM (15.5%–8.7%) and non-ICM (14.2%–8.2%) declined across eras, but minimal decline was observed in HCM patients (11.7%–9.6%;
P
=0.06). In era 2, the 12-month rate of HT in HCM (64.8%) was comparable to that of ICM (60.9%) and non-ICM (62.7%) patients (
P
=0.06). Post-transplant survival in HCM patients was the most favorable in the most recent era (1 year: 91.6% and 5 years: 82.5%;
P
<0.05 for all comparisons).

Conclusions:
The number of patients with HCM in need of HT is increasing. Although post-transplant survival in HCM is excellent, waitlist mortality is substantial and with minimal decline in the most recent era, despite the frequent use of listing status upgrade by exception in this patient cohort. Different strategies to improve the performance of the organ allocation system in patients with HCM are needed.
Mechanical Circulatory Support Device Utilization and Heart Transplant Waitlist Outcomes in Patients With Restrictive and Hypertrophic Cardiomyopathy
Authors: Sridharan Lakshmi , Wayda Brian , Truby Lauren K. , Latif Farhana , Restaino Susan , Takeda Koji , Takayama Hiroo , Naka Yoshifumi , Colombo Paolo C. , Maurer Mathew , Farr Maryjane A. , Topkara Veli K. 
Published: March 2018

Background:
Patients with restrictive cardiomyopathy (RCM) and hypertrophic cardiomyopathy (HCM) generally are considered poor candidates for mechanical circulatory support devices (MCSDs) and often not able to be bridged mechanically to heart transplantation. This study characterized MCSD utilization and transplant waitlist outcomes in patients with RCM/HCM under the current allocation system and discusses changes in the era of the new donor allocation system.

Methods and Results:

Patients waitlisted from 2006 to 2016 in the United Network for Organ Sharing registry were stratified by RCM/HCM versus other diagnoses. MCSD utilization and waitlist duration were analyzed by propensity score models. Waitlist outcomes were assessed by cumulative incidence functions with competing events. Predictors of waitlist mortality or delisting for worsening status in patients with RCM/HCM were identified by proportional hazards model. Of 30 608 patients on the waitlist, 5.1% had RCM/HCM. Patients with RCM/HCM had 31 fewer waitlist days (
P
<0.01) and were ≈26% less likely to receive MCSD (
P
<0.01). Cumulative incidence of waitlist mortality was similar between cohorts; however, patients with RCM/HCM had higher incidence of heart transplantation. Predictors of waitlist mortality or delisting for worsening status in patients with RCM/HCM without MCSD support included estimated glomerular filtration rate <60 mL/min per 1.73 m
2
, pulmonary capillary wedge pressure >20 mm Hg, inotrope use, and subjective frailty.

Conclusions:
Patients with RCM/HCM are less likely to receive MCSD but have similar waitlist mortality and slightly higher incidence of transplantation compared with other patients. The United Network for Organ Sharing RCM/HCM risk model can help identify patients who are at high risk for clinical deterioration and in need of expedited heart transplantation.
Arterial Wall Imaging in Pediatric Stroke
Authors: Dlamini Nomazulu , Yau Ivanna , Muthusami Prakash , Mikulis David J. , Elbers Jorina , Slim Mahmoud , Askalan Rand , MacGregor Daune , deVeber Gabrielle , Shroff Manohar , Moharir Mahendranath 
Published: March 2018

Background and Purpose—
Arteriopathy is common in childhood arterial ischemic stroke (AIS) and predicts stroke recurrence. Currently available vascular imaging techniques mainly image the arterial lumen rather than the vessel wall and have a limited ability to differentiate among common arteriopathies. We aimed to investigate the value of a magnetic resonance imaging-based technique, namely noninvasive arterial wall imaging (AWI), for distinguishing among arteriopathy subtypes in a consecutive cohort of children presenting with AIS.

Methods—
Children with confirmed AIS and magnetic resonance angiography underwent 3-Tesla AWI including T1-weighted 2-dimensional fluid-attenuated inversion recovery fast spin echo sequences pre- and post-gadolinium contrast. AWI characteristics, including wall enhancement, wall thickening, and luminal stenosis, were documented for all.

Results—
Twenty-six children with AIS had AWI. Of these, 9 (35%) had AWI enhancement. AWI enhancement was associated with anterior circulation magnetic resonance angiography abnormality and cortical infarction in 8 of 9 (89%) children and normal magnetic resonance angiography with posterior circulation subcortical infarction in 1 (1 of 9; 11%) child. AWI enhancement was not seen in 17 (65%), 10 (59%) of whom had an abnormal magnetic resonance angiography. Distinct patterns of pre- and postcontrast signal abnormality were demonstrated in the vessel wall in the region of interest in children with transient cerebral arteriopathy, arterial dissection, primary central nervous system angiitis, dissecting aneurysm, and cardioembolic stroke.

Conclusions—
AWI is a noninvasive, high-resolution magnetic resonance AWI technique, which can be successfully used in children presenting with AIS. Patterns of AWI enhancement are recognizable and associated with specific AIS pathogeneses. Further studies are required to assess the additional diagnostic utility of AWI over routine vascular imaging techniques, in childhood AIS.
Eligibility for Endovascular Trial Enrollment in the 6- to 24-Hour Time Window
Authors: Jadhav Ashutosh P. , Desai Shashvat M. , Kenmuir Cynthia L. , Rocha Marcelo , Starr Matthew T. , Molyneaux Bradley J. , Gross Bradley A. , Jankowitz Brian T. , Jovin Tudor G. 
Published: March 2018

Background and Purpose—
The results of the DAWN trial (Diffusion-Weighted Imaging or Computerized Tomography Perfusion Assessment With Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention With Trevo) support the benefit of endovascular therapy in patients presenting beyond the 6-hour time window with anterior circulation large vessel occlusions. The impact of these results with respect to additional number of eligible patients in clinical practice remains unknown.

Methods—
A retrospective review of ischemic stroke admissions to a single DAWN trial-participating comprehensive stroke center was performed during the DAWN enrollment period (November 2014 to February 2017) to identify patients meeting criteria for DAWN and DEFUSE-3 (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke-3) eligibility. Patients presenting beyond 6 hours were further investigated to clarify reasons for trial exclusion.

Results—
Of the 2667 patients with acute ischemic stroke admitted within the study period, 30% (n=792) presented within the 6- to 24-hour time window, and 47% (n=1242) had a National Institutes of Health Stroke Scale ≥6. Further clinical trial-specific selection criteria were applied based on the presence of large vessel occlusion, baseline modified Rankin Scale score, core infarct, and perfusion imaging (when available). There were 45 patients who met all DAWN trial criteria and 47 to 58 patients who would meet DEFUSE-3 trial criteria. Thirty-three percent of DAWN-eligible patients are DEFUSE-3 ineligible.

Conclusions—
Of all patients with acute ischemic stroke presenting to a single comprehensive stroke center, 1.7% of patients qualified for DAWN clinical trial enrollment with an additional 0.6% to 1% qualifying for the DEFUSE-3 trial. These data predict an increase in thrombectomy utilization with important implications for comprehensive stroke center resource optimization and stroke systems of care.
How to Think the Infinite: A New Reading and Interpretation of Aristotle, Metaphysics 2.2, 994b21-27
Authors: Kotwick Mirjam E. , Pfeiffer Christian 
Published: March 2018

AbstractInMetaphysics2.2, 994b21-27 Aristotle comments on how it is possible to think something that is infinitely divisible. Given that Aristotle denies elsewhere that it is possible to think an infinite number of items the passage offers important evidence for Aristotle’s positive account of how one can think something that is infinite. However, Aristotle’s statement inMetaphysics2.2 has puzzled interpreters since antiquity. This puzzlement has been partly due to a textual problem in the passage. In this paper we first restore the original reading ofMetaph. 2.2, 994b25-26 by making use of the evidence in Alexander of Aphrodisias’s commentary and second make sense of the restored passage by interpreting it in light of Aristotle’s thoughts on the infinite inPhysics3 and 8.
Callimachus’ Taxonomy of Men (Iamb 2.10-13)
Authors: Greene Robin J. 
Published: March 2018

AbstractThis study argues that Callimachus’ treatment of his ‘animal-voiced’ contemporaries at the conclusion of the fable inIamb2 reflects zoological and physiognomic practices so as to represent the poetic narrator as a taxonomist of men. Elsewhere the classification of men as if they were flora or fauna appears, like fable itself, in distinctly moral and ethical contexts, as, for example, in Theophrastus’Characters. Callimachus’ formulation of his narrator as a taxonomist who classifies ‘species’ of men based upon their literary ‘voices’ thus plays with modes of invective new toiamboswhile uniting moral criticism with literary polemic.
Reynard the Fox and the Art of Printing (Reineke Fuchs und die Buchdruckerkunst)
Authors: Speth Sebastian 
Published: March 2018

Johann Christoph Gottsched glorifies the benefits of printing for the acquisition, conservation, and distribution of knowledge. Praising the Low German Reynke de vos he expects furthermore the inspiration from the art of printing for the emergence of a contemporary German epic. This article compares different versions of Reineke-stories relating to their variable peritextual presentation. This includes titles, covers, and other paratextual dimensions of the works. But as a product of collective retelling, the fox epic joins completely different literary genres.
Johann Christoph Gottsched preist die Leistungen des Buchdrucks bei der Aneignung, Bewahrung und Verbreitung von Wissen. Ausgehend von einem Lob des niederdeutschen Reynke de vos hofft er darüber hinaus, die Druckkunst werde zur Inspirationsquelle für ein zeitgenössisches ‘Heldengedicht’ in deutscher Sprache. Im vorliegenden Beitrag wird der Vergleich verschiedener Reineke-Fassungen nicht auf die bloße Vershandlung reduziert. Im Zentrum steht die Inszenierung durch textgeschichtlich variable Titelbilder, -formulierungen sowie weitere peritextuelle Werkdimensionen. Als Produkt eines gemeinsamen Wiedererzählens von Verfassern und Überlieferungsbeteiligten gerät die Fuchsgeschichte jedoch in ganz andere Gattungskontexte.
Improvements in Hurricane Intensity Forecasts from a Multimodel Superensemble Utilizing a Generalized Neural Network Technique
Authors: Ghosh T. , Krishnamurti T. N. 
Published: March 2018

Abstract
Forecasting tropical storm intensities is a very challenging issue. In recent years, dynamical models have improved considerably. However, for intensity forecasts more improvement is necessary. Dynamical models have different kinds of biases. Considering a multimodel consensus could eliminate some of the biases resulting in improved intensity forecasts as compared to the individual models. Apart from the ensemble mean, the construction of multimodel consensuses has always contributed to somewhat improved forecasts. The Florida State University (FSU) multimodel superensemble is one that, over the years, has systematically provided improved forecasts for hurricanes, numerical weather prediction, and seasonal climate forecasts. The present study considers an artificial neural network (ANN), based on biological principles, for the construction of a multimodel ensemble. ANN has been used for constructing multimodel consensus forecasts for tropical cyclone intensities. This study uses the generalized regression neural network (GRNN) method for the construction of consensus intensity forecasts for the Atlantic basin. Hurricane seasons 2012–16 are considered. Results show that with only five input models improved guidance for tropical storm intensities may be obtained. The consensus using GRNN mostly outperforms all the models included in the study and the ensemble mean. Forecast errors at the longer forecast leads are considerably less for this multimodel superensemble based on the generalized regression neural network. The skill and correlations of different models along with the developed consensus are provided in our analysis. Results suggest that this consensus forecast may be used for operational guidance and for planning and emergency evacuation management. Possibilities for future improvements of the consensus based on new advances in statistical algorithms are also indicated.
Newly Diagnosed Meniere’s Disease: Clinical Course With Initiation of Noninvasive Treatment Including an Accounting of Vestibular Migraine
Authors: Sbeih Firas , Christov Florian , Gluth Michael B. 
Published: March 2018

Objective: To describe the course of Meniere’s disease with noninvasive treatment during the first few years after initial diagnosis. Methods: A retrospective review of consecutive patients with newly diagnosed definite Meniere’s disease between 2013 and 2016 and a minimum follow-up of 1 year. Patients received a written plan for low sodium, water therapy, and treatment with a diuretic and/or betahistine. Subjects were screened and treated for vestibular migraine as needed. Vertigo control and hearing status at most recent follow-up were assessed. Results: Forty-four subjects had an average follow up of 24.3 months. Thirty-four percent had Meniere’s disease and vestibular migraine, and 84% had unilateral Meniere’s disease. Seventy-five percent had vertigo well controlled at most recent follow-up, with only noninvasive treatments. Age, gender, body mass index, presence of vestibular migraine, bilateral disease, and duration of follow-up did not predict noninvasive treatment failure. Worse hearing threshold at 250 Hz and lower pure tone average (PTA) at the time of diagnosis did predict failure. Fifty-two percent of ears had improved PTA at most recent visit, 20% had no change, and 28% were worse Conclusions: Encountering excellent vertigo control and stable hearing after a new diagnosis of Meniere’s disease is possible with noninvasive treatments. Worse hearing status at diagnosis predicted treatment failure.
Subtypes of suicidal ideation in Korean adolescents: A multilevel latent profile analysis
Authors: Jung Song , Lee Dayoung , Park Seongjun , Hong Hyun Ju 
Published: March 2018

Objective: This study intended to classify subtypes of Korean adolescents with suicidal ideation based on mental health problems and to explore the relationship between such subtypes and individual-, school- and community-level factors. Method: Data from high school freshmen who participated in the 2013 school-based mental health screening test and data about school and community variables obtained from public sources were combined and analyzed. A multilevel latent profile analysis using mental health issues as class indicators that included several predictors was conducted. Results: Three latent profiles were identified: Group 1 (6.5%) had high scores for both the internalizing and externalizing problems; Group 2 (40.2%) had high scores for internalizing problems, such as depression and mood related symptoms; and Group 3 (53.3%) had lower scores for all mental health problems compared to Groups 1 and 2. Gender, peer conflict, family conflict and academic problems were significant predictors at the individual level; school dropout rate was a significant school-level variable; and percent of youth in the total population, availability of mental health services, number of social welfare facilities and percentage of the total budget devoted to education/welfare were significant community-level variables. Conclusion: The present findings suggest that adolescents with suicidal ideation can be classified into several distinct subtypes based on mental health problems. These profiles and their associated covariates will aid in the establishment of youth suicide prevention policies.
Complementary Role of Hypothermia Identification to the Quick Sequential Organ Failure Assessment Score in Predicting Patients With Sepsis at High Risk of Mortality: A Retrospective Analysis From a Multicenter, Observational Study
Authors: Kushimoto Shigeki , Gando Satoshi , Ogura Hiroshi , Umemura Yutaka , Saitoh Daizoh , Mayumi Toshihiko , Fujishima Seitaro , Abe Toshikazu , Shiraishi Atsushi , Ikeda Hiroto , Kotani Joji , Miki Yasuo , Shiraishi Shin-ichiro , Suzuki Koichiro , Suzuki Yasushi , Takeyama Naoshi , Takuma Kiyotsugu , Tsuruta Ryosuke , Yamaguchi Yoshihiro , Yamashita Norio , Aikawa Naoki 
Published: March 2018

Background: Although the quick Sequential Organ Failure Assessment (qSOFA) has been recommended for identifying patients at higher risk of hospital death, it has only a 60% sensitivity for in-hospital mortality. On the other hand, hypothermia associates with increased mortality and organ failure in patients with sepsis. This study aimed to assess the predictive validity of qSOFA for identifying patients with sepsis at higher risk of multiple organ dysfunction or death and the complementary effect of hypothermia. Methods: Patients with severe sepsis admitted to intensive care units (ICUs) were retrospectively analyzed. The predictive validities of qSOFA (≥2, positive) and the complementary effect of hypothermia (body temperature ≤36.5°C) for the identification of death or multiorgan dysfunction were evaluated. Results: Of the 624 patients, 230 (36.9%) developed multiorgan dysfunction and 144 (23.1%) died within 28 days; 527 (84.5%) had a positive qSOFA. The 28-day mortality rates of patients with positive and negative qSOFA were 25.4% and 10.3%, respectively ( P = .001). The rate of positive qSOFA was higher in patients with multiorgan dysfunction (sensitivity, 0.896; specificity, 0.185) and among patients who died within 28 days (sensitivity, 0.931; specificity, 0.181); 10 (6.9%) of 144 deaths were not identified. In cases of positive qSOFA without hypothermia, positive qSOFA + hypothermia, or negative qSOFA with hypothermia, the predictive value for 28-day mortality improved (sensitivity, 0.979). Among the 144 patients who died, only 3 were not identified. Conclusion: A qSOFA score ≥2 may identify >90% of 28-day deaths among patients with severe sepsis; hypothermia may complement the predictive ability of qSOFA.
A Bayesian approach for the segmentation of series with a functional effect
Authors: Baragatti Meili , Bertin Karine , Lebarbier Emilie , Meza Cristian 
Published: March 2018

Abstract: In some application fields, series are affected by two different types of effects: abrupt changes (or change-points) and functional effects. We propose here a Bayesian approach that allows us to estimate these two parts. Here, the underlying piecewise-constant part (associated to the abrupt changes) is expressed as the product of a lower triangular matrix by a sparse vector and the functional part as a linear combination of functions from a large dictionary where we want to select the relevant ones. This problem can thus lead to a global sparse estimation and a stochastic search variable selection approach is used to this end. The performance of our proposed method is assessed using simulation experiments. Applications to three real datasets from geodesy, agronomy and economy fields are also presented.