bluuebunny/crossref_metadata_2025_split huggingface dataset:
VEGF with AMD3100 endogenously mobilizes mesenchymal stem cells and improves fracture healing
Authors: Meeson Richard , Sanghani‐Keri Anita , Coathup Melanie , Blunn Gordon 
Published: October 2018

ABSTRACTA significant number of fractures develop non‐union. Mesenchymal stem cell (MSC) therapy may be beneficial, however, this requires cell acquisition, culture and delivery. Endogenous mobilization of stem cells offers a non‐invasive alternative. The hypothesis was administration of VEGF and the CXCR4 antagonist AMD3100 would increase the circulating pool of available MSCs and improve fracture healing. Ex‐breeder female wistar rats received VEGF followed by AMD3100, or sham PBS. Blood prepared for culture and colonies were counted. P3 cells were analyzed by flow cytometry, bi‐differentiation. The effect of mobilization on fracture healing was evaluated with 1.5 mm femoral osteotomy stabilized with an external fixator in 12–14 week old female Wistars. The mobilized group had significantly greater number of cfus/ml compared to controls, p = 0.029. The isolated cells expressed 1.8% CD34, 35% CD45, 61% CD29, 78% CD90, and differentiated into osteoblasts but not into adipocytes. The fracture gap in animals treated with VEGF and AMD3100 showed increased bone volume; 5.22 ± 1.7 µm3 and trabecular thickness 0.05 ± 0.01 µm compared with control animals (4.3 ± 3.1 µm3, 0.04 ± 0.01 µm, respectively). Radiographic scores quantifying fracture healing (RUST) showed that the animals in the mobilization group had a higher healing score compared to controls (9.6 vs. 7.7). Histologically, mobilization resulted in significantly lower group variability in bone formation (p = 0.032) and greater amounts of bone and less fibrous tissue than the control group. Clinical significance: This pre‐clinical study demonstrates a beneficial effect of endogenous MSC mobilization on fracture healing, which may have translation potential to prevent or treat clinical fractures at risk of delayed or non‐union fractures. © 2018 The Authors. Journal of Orthopaedic Research® Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 37:1294–1302, 2019.
American Society for Parenteral and Enteral Nutrition Guidelines for the Selection and Care of Central Venous Access Devices for Adult Home Parenteral Nutrition Administration
Authors: Kovacevich Debra S. , Corrigan Mandy , Ross Vicki M. , McKeever Liam , Hall Amber M. , Braunschweig Carol 
Published: October 2018

AbstractThis document represents the American Society for Parenteral and Enteral Nutrition (ASPEN) clinical guidelines to describe best practices in the selection and care of central venous access devices (CVADs) for the infusion of home parenteral nutrition (HPN) admixtures in adult patients. The guidelines targeted adults >18 years of age in which the intervention or exposure had to include HPN that was administered via a CVAD. Case studies, non‐English studies, or studies of CVAD no longer available in the United States were excluded. In total, 564 abstract citations, 350 from Medline and 214 from PubMed/non‐MEDLINE databases, were scanned for relevance. Of the 564 citations, 13 studies addressed at least 1 of the 6 guideline‐related questions, and none of the studies were prospective and randomized. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria were used to adjust the evidence grade based on assessment of the quality of study design and execution. Recommendations for the CVAD type, composition, or number of lumens to minimize infectious or mechanical complications are based on a limited number of studies and expert opinion of the authors, all very experienced in home infusion therapy. No studies were found that compared best solutions for routine flushing of lumens (eg, heparin versus saline) or for maintaining catheters in situ while treating CVAD mechanical or infectious complications. It is clear that studies to answer these questions are very limited, and further research is needed. These clinical guidelines were approved by the ASPEN Board of Directors.
Identification of new psychoactive substances (NPS) by Raman spectroscopy
Authors: Omar Jone , Slowikowski Boleslaw , Guillou Claude , Reniero Fabiano , Holland Margaret , Boix Ana 
Published: October 2018

AbstractThere is an increasing need of developing methods for fast recognition and identification of new psychoactive substances (NPS). The chemical identification of these new substances produced with the intention of mimicking the effects of controlled drugs is a challenge for forensic and Customs laboratories. In this study, we aim to test the potential of Raman spectroscopy for the identification and classification of seized Customs samples into three NPS families. The performance of two excitation wavelength lasers (785 and 1064 nm) in a benchtop Raman instrument was compared in a set of seized samples that included cathinone, fentanyl, and synthetic cannabinoid derivatives or analogues. The 1064 nm wavelength laser had significant advantages for identifying NPS samples overcoming the intense fluorescence induced when using 785 nm lasers in some substances. Principal component analysis was employed to create a model that successfully discriminates the three NPS families. In order to provide Customs officers with a fast and nondestructive in‐field testing method, the same approach used with the benchtop Raman spectrometer was applied using three handheld Raman instruments. The developed identification and classification model allows the discrimination of fentanyl, cathinone, and synthetic cannabinoid analogues or derivatives providing an efficient tool for the rapid identification of three NPS families. The approach presented in this study can facilitate rapid decision‐making that could be of high relevance especially in the frame of the fentanyl crisis.
Structural characterization and biological fate of lactoferrin‐loaded liposomes during simulated infant digestion
Authors: Tian Mengmeng , Han Jianzhong , Ye Aiqian , Liu Weilin , Xu Xiankang , Yao Yixin , Li Kexuan , Kong Youyu , Wei Fuqiang , Zhou Wei 
Published: October 2018

AbstractBACKGROUNDLimited information is concerned on the structure changes of liposomal delivery system under infant conditions. Positively charged lactoferrin (LF)‐loaded liposomes, with the entrapment efficiency (EE) of 52.3 ± 6.3%, were prepared from soybean‐derived phospholipids using a thin‐layer dispersion method. The structure changes and digestibility of LF‐loaded liposomes under infant conditions, including simulated gastric fluid (SGF) and simulated small intestinal fluid (SIF), were characterized in terms of the average particle size, zeta potential, turbidity, fourier transform infrared, transmission electron microscopy, lipolysis and protein hydrolysis.RESULTSThis study showed that the functional groups, favorable membrane structure and the EE of liposomes were slightly changed as a function of time when the liposome digested under SGF conditions. However, the intact bilayer structures were damaged and the EE of LF‐loaded liposomes decreased to 28.5% after digestion in infant SIF.CONCLUSIONThese results suggested that liposomal membrane could prevent the gastric degradation and the structure of liposomes was not completely destroyed with a low concentration of pancreatin and bile salts under infant conditions. Present study provided information on the insight into the characteristics of liposomes during infant gastrointestinal digestion, which was useful for the development of microcapsule systems in infant diet. © 2018 Society of Chemical Industry
Quantitative evaluation method of visual display resolution based on human visual perception
Authors: Choi Kyuha , Min Byungseok 
Published: October 2018

AbstractAs a manner of evaluating visual display resolution, contrast modulation has been widely used for decades. But, as various types of sub‐pixel layout are adopted for flat panel displays, the contrast modulation metric shows a limitation that it is not consistent with human visual perception on those displays. To overcome this limitation, a new quantitative metric is proposed in this paper by introducing structure comparison and combining it with contrast modulation. Experimental results performed on TV displays with various sub‐pixel structures demonstrate that the proposed metric has higher correlation with perceived visual resolution than the conventional metric.
Facilitators and Barriers to Seeking Mental Health Care Among Primary Care Veterans With Posttraumatic Stress Disorder
Authors: Possemato Kyle , Wray Laura O. , Johnson Emily , Webster Brad , Beehler Gregory P. 
Published: October 2018

AbstractAlthough posttraumatic stress disorder (PTSD) is common in primary care patients, many do not seek mental health treatment. Existing research on barriers and facilitators to receiving PTSD treatment are not specific to primary care patients. In this study, we sought to understand the psychosocial concerns, treatment barriers, and treatment facilitators among non‐treatment‐seeking primary care veterans with PTSD who reside in both rural and urban settings. Using a concurrent triangulation design, we collected qualitative focus group and quantitative self‐report data concurrently, analyzed them separately, and merged the results for interpretation. In total, 27 veteran primary care patients with PTSD participated in 1 of 4 focus groups. A modified conventional content analysis approach was used. Team‐based coding began with three broad primary codes (psychosocial concerns, barriers, and facilitators) and subcodes were allowed to emerge from the data. Self‐report measures were used to collect clinical characteristics and barriers to care. The results expanded upon existing models of PTSD treatment initiation by (a) specifying treatment preferences, such as patient‐centered care, peer support services, and open access scheduling, and (b) presenting concerns, such as anger and core symptoms of PTSD. Results also indicated that a commonly used quantitative barriers measure may offer an incomplete picture of why veterans do not seek treatment as it does not assess how past negative treatment experiences may affect utilization. Strategies to help veterans overcome barriers to care may benefit from a focus on negative treatment‐seeking beliefs and tailoring based on a veteran's rural or urban status.
Longitudinal Development of Primary and Secondary Posttraumatic Growth in Aging Veterans and Their Wives: Domain‐Specific Trajectories
Authors: Bachem Rahel , Mitreuter Saskia , Levin Yafit , Stein Jacob Y. , Xiao Zhou , Solomon Zahava 
Published: October 2018

AbstractPosttraumatic growth (PTG), the positive psychological transformations that follow traumatic events, affects both direct survivors (primary PTG) and their significant others (secondary PTG). Though primary and secondary PTG have been widely investigated in the literature, their long‐term trajectories decades after a traumatic event, especially as survivors enter older age, remain largely uninvestigated. Furthermore, it remains contested whether PTG adds up to a monolithic construct or rather consists of relatively independent components. Addressing these issues, we assessed a sample of Israeli male veterans from the 1973 Yom Kippur war (N = 349) and their wives (N = 156) at three time points over the course of nearly three decades. Both the veterans (primary survivors) and their wives (secondary survivors) reported PTG relating to the veterans' experiences during the war and/or captivity. Latent growth mixture modeling was conducted to identify trajectories of PTG on the five subscales of the Posttraumatic Growth Inventory. Long‐term trajectories of PTG followed heterogeneous patterns of fluctuation over time and particularly as participants entered older age. On most subscales, decreasing PTG scores were evident, a trend that was more pronounced among the primary survivors than the secondary survivors as primary and secondary PTG fluctuate considerably in the long‐term and seem to decrease as individuals enter older age. Furthermore, it would seem that PTG should not be considered a holistic concept but rather a conglomeration of positive changes. Implications of the findings are discussed within the context of limitations and potential intervening factors.
Posttraumatic Stress Symptoms and Emerging Adult Sexual Minority Men: Implications for Assessment and Treatment of Childhood Sexual Abuse
Authors: Boroughs Michael S. , Ehlinger Peter P. , Batchelder Abigail W. , Safren Steven A. , O'Cleirigh Conall 
Published: October 2018

AbstractEmerging adulthood (EA) is a developmental period marked by unique challenges that affect health including burgeoning occupational, relational, and financial stability; and increased risk taking in terms of sexual behavior(s) and substance use. Data were collected from 296 HIV‐uninfected sexual minority men with childhood sexual abuse (CSA) histories. We analyzed baseline assessment data from a multisite randomized controlled trial that tested the efficaciousness of an experimental psychosocial treatment and examined vulnerabilities known to be linked with CSA. Our analyses compared EA sexual minority men, aged 18–29, with older sexual minority men (OSMM) on posttraumatic stress disorder (PTSD) and other mental health and substance use outcomes. We found higher odds of PTSD, odds ratio (OR) = 0.57, 95% CI [0.33, 0.96]; panic disorder or panic disorder with agoraphobia, OR = 0.36, 95% CI [0.16, 0.85]; and cocaine use, OR = 0.50, 95% CI [0.25, 0.97], among OSMM and higher odds of alcohol intoxication, OR = 5.60, 95% CI [3.20, 9.82]; cannabis use, OR = 3.09, 95% CI [1.83, 5.21]; and non‐HIV sexually transmitted infections, OR = 3.03, 95% CI [1.29, 7.13], among the EA men. These results present a complex picture of health risks among sexual minority men in general and EA sexual minority men in particular. HIV seroconversion linked health risk behaviors, among sexual minority men, may be better addressed via increased attention to treating trauma and comorbid mental health and substance use problems using evidence‐based psychosocial assessments and integrated treatment platforms that are tailored to this population.
Impacts of mining and smelting activities on environment and landscape degradation—Slovenian case studies
Authors: Žibret Gorazd , Gosar Mateja , Miler Miloš , Alijagić Jasminka 
Published: October 2018

AbstractThis paper provides an overview of the physical and chemical landscape changes that have occurred at four reference sites due to historical mining and smelting activities within Slovenia, and their comparison with similar sites around the World. Literature review has been made with the intention to identify major pollutant sources, its dispersion control factors, and effects. The four reference sites are Idrija, with more than 500‐year Hg mining and ore smelting history, the Meža Valley, also with a 500‐year PbZn mining and smelting history, the Celje area where Zn was smelted for 100 years and the Drava River alluvial plain, which is contaminated because of historical PbZn mining upstream. Based on the comparison between the four abovementioned reference sites and similar sites around the world that are situated in different landscapes and climates, we identified major sources of contamination, which are the erosion of mine and ore processing wastes, and atmospheric emissions of metal‐containing particles from smelters. In the first case, major control factors are rainfall pattern and river gradient, controlling erosion and sediment deposition patterns. In the second case, the prevailing control factors are topography and the dominant wind directions.
Proton pump inhibitors: Review of reported risks and controversies
Authors: Brisebois Simon , Merati Albert , Giliberto John Paul 
Published: October 2018

Proton pump inhibitors (PPIs) are among the most prescribed classes of drugs in this day and age. These may be beneficial to treat many gastrointestinal conditions, such as gastroesophageal reflux or Barrett's esophagus as well as laryngopharyngeal reflux. However, many reports have emerged in the literature exposing the potential association of PPIs with various risks and complications such as bone fracture, infection, myocardial infarction, renal disease, and dementia. This review highlights many of these potential adverse side effects by exploring relevant publications and addressing the controversies associated with those findings. The diligent otolaryngologist should be aware of the current state of the literature and the risks associated with prescribing PPIs to insure proper counseling of their patients.Level of Evidence5
Enhanced broadband common‐mode filter based on periodic electromagnetic bandgap structures
Authors: Lim Jaehyuk , Oh Sangyeol , Lee Seungjin , Yoon Wonsang , Lee Jaehoon 
Published: October 2018

AbstractIn this article, we present an enhanced broadband common‐mode (CM) noise filter based on periodic electromagnetic bandgap (EBG) structures with transmission lines. The unit‐cell of the proposed filter is composed of a mushroom‐like resonator and transmission lines. We developed a lumped circuit model with transmission lines to enable analysis of the unit‐cell using the Bloch‐Floquet theorem. The dispersion relations derived from the Bloch‐Floquet theorem have CM suppression characteristics with respect to various circuit parameters. Although optimizing the period of the EBGs by the transmission line length widens the CM noise stop band, the impedance mismatching between the EBGs and the transmission lines causes differential‐mode (DM) insertion loss. We solved this problem by adjusting the characteristic impedance of the DM signals on the EBG. We then built a prototype of the proposed CM noise filter and measured its performance. The frequency range of the 20‐dB CM noise stop band was measured to be 5.3‐9.74 GHz. The DM insertion loss was measured to be < 3 dB from DC to 10 GHz.
Extraction of device S‐parameters within board by using a TRL de‐embedding technique
Authors: Hamze Kassem , Pasquet Daniel , Descamps Philippe , De Ledinghen Edouard 
Published: October 2018

AbstractSemiconductor devices are tested within a complex environment including a loadboard and a socket. In this paper, we propose a calibration methodology and a RF de‐embedding technique that allows the extraction of the device parameters. This method is based on the utilization of several calibration elements inspired by the TRL method. This study has been applied on an active device and the results have been validated using a real test solution.
Decoupling and MIMO performance of two planar monopole antennas with protruded strips
Authors: Abbosh Ayman , Al‐Rizzo Hussain , Yahya Samer , Al‐Wahhamy Abbas 
Published: October 2018

AbstractThis paper proposes a simple yet elegant approach to reduce mutual coupling between two closely spaced planar monopole antennas with an inter‐element spacing of 2 mm operating in the 2.45 GHz ISM band by employing two thin metallic strips attached to the adjacent corners of the antenna elements and extending above the partial ground plane. Experimental results revealed a 19.6% measured bandwidth over which the transmission coefficient, S21 ≤ −20 dB, and the reflection coefficient, S11 ≤ −10 dB, extending from 2.25 GHz to 2.74 GHz with a realized gain of 2.86 dB at 2.45 GHz. The proposed array offers excellent MIMO performance in terms of envelope correlation coefficient and link efficiency in realistic MIMO propagation environments.
Automated quantification and evaluation of motion artifact on coronary CT angiography images
Authors: Ma Hongfeng , Gros Eric , Baginski Scott G. , Laste Zachary R. , Kulkarni Naveen M. , Okerlund Darin , Schmidt Taly G. 
Published: October 2018

PurposeThis study developed and validated a Motion Artifact Quantification algorithm to automatically quantify the severity of motion artifacts on coronary computed tomography angiography (CCTA) images. The algorithm was then used to develop a Motion IQ Decision method to automatically identify whether a CCTA dataset is of sufficient diagnostic image quality or requires further correction.MethodThe developed Motion Artifact Quantification algorithm includes steps to identify the right coronary artery (RCA) regions of interest (ROIs), segment vessel and shading artifacts, and to calculate the motion artifact score (MAS) metric. The segmentation algorithms were verified against ground‐truth manual segmentations. The segmentation algorithms were also verified by comparing and analyzing the MAS calculated from ground‐truth segmentations and the algorithm‐generated segmentations. The Motion IQ Decision algorithm first identifies slices with unsatisfactory image quality using a MAS threshold. The algorithm then uses an artifact‐length threshold to determine whether the degraded vessel segment is large enough to cause the dataset to be nondiagnostic. An observer study on 30 clinical CCTA datasets was performed to obtain the ground‐truth decisions of whether the datasets were of sufficient image quality. A five‐fold cross‐validation was used to identify the thresholds and to evaluate the Motion IQ Decision algorithm.ResultsThe automated segmentation algorithms in the Motion Artifact Quantification algorithm resulted in Dice coefficients of 0.84 for the segmented vessel regions and 0.75 for the segmented shading artifact regions. The MAS calculated using the automated algorithm was within 10% of the values obtained using ground‐truth segmentations. The MAS threshold and artifact‐length thresholds were determined by the ROC analysis to be 0.6 and 6.25 mm by all folds. The Motion IQ Decision algorithm demonstrated 100% sensitivity, 66.7% ± 27.9% specificity, and a total accuracy of 86.7% ± 12.5% for identifying datasets in which the RCA required correction. The Motion IQ Decision algorithm demonstrated 91.3% sensitivity, 71.4% specificity, and a total accuracy of 86.7% for identifying CCTA datasets that need correction for any of the three main vessels.ConclusionThe Motion Artifact Quantification algorithm calculated accurate (<10% error) motion artifact scores using the automated segmentation methods. The developed algorithms demonstrated high sensitivity (91.3%) and specificity (71.4%) in identifying datasets of insufficient image quality. The developed algorithms for automatically quantifying motion artifact severity may be useful for comparing acquisition techniques, improving best‐phase selection algorithms, and evaluating motion compensation techniques.