bluuebunny/crossref_metadata_2025_split huggingface dataset:
Affective territories: cartography of aconchego as cartography of power
Authors: Hutta Jan Simon 
Published: August 2019

The paper introduces an affective approach to the study of territory andterritoriality. Previous discussions of ‘territoriality’, it is shown, have commonlyfocused on symbolic dimensions. Where affect has been addressed, it has beenmostly in relation to the ‘topophilic bond’ of people and territory. Instead, thepaper suggests understanding both re- and deterritorialization processes asinherently affective. This draws attention to how a series of affective ‘vectors’ –including fear and aconchego – intensify or dampen de- and reterritorializations.Moreover, it sheds new light on the formation of capacities of acting in spatialcontext. To develop this argument, the paper draws on approaches to affectthat are inspired by Gilles Deleuze’s reading of Spinoza. It then uses theexamples of fear and what in Portuguese is called aconchego to illustrate some of the analytic questions thus arising. What emerges is an affective cartographythat entails understanding power relations as affective, rendering previousdistinctions between ‘territory’ and ‘territoriality’ questionable.
Endothelial Activation Markers as Disease Activity and Damage Measures in Juvenile Dermatomyositis
Authors: Kishi Takayuki , Chipman Jonathan , Evereklian Melvina , Nghiem Khanh , Stetler-Stevenson Maryalice , Rick Margaret E. , Centola Michael , Miller Frederick W. , Rider Lisa G. 
Published: August 2019

Objective.Circulating endothelial cells (CEC), von Willebrand factor (vWF) antigen, P-selectin, and thrombomodulin are released from damaged endothelium, while decreases in circulating endothelial progenitor cells (CEPC) have been associated with poor vascular outcomes. We examined these markers in the peripheral blood of patients with juvenile dermatomyositis (JDM) and their correlations with disease assessments.Methods.Peripheral blood endothelial cells and biomarkers were assessed in 20 patients with JDM and matched healthy controls. CEC and CEPC were measured by flow cytometry, while vWF antigen and activity, factor VIII, P-selectin, and thrombomodulin were measured in plate-based assays. Disease activity and damage, nailfold capillary density, and brachial artery flow dilation were assessed. Serum cytokines/chemokines were measured by Luminex.Results.CEC, vWF antigen, factor VIII, and thrombomodulin, but not vWF activity, CEPC, or P-selectin, were elevated in the peripheral blood of patients with JDM. CEC correlated with pulmonary activity (rs= 0.56). The vWF antigen correlated with Patient’s/Parent’s Global, cutaneous, and extramuscular activity (rs= 0.47–0.54). CEPC negatively correlated with muscle activity and physical function (rs= −0.52 to −0.53). CEPC correlated inversely with endocrine damage. The vWF antigen and activity correlated with interleukin 10 and interferon-gamma inducible protein-10 (rs= 0.64–0.82).Conclusion.Markers of endothelial injury are increased in patients with JDM and correlate with extramuscular activity. CEPC correlate inversely with muscle activity, suggesting a functional disturbance in repair mechanisms.
The Relation of Physical Comorbidity and Multimorbidity to Fibromyalgia, Widespread Pain, and Fibromyalgia-related Variables
Authors: Wolfe Frederick , Ablin Jacob , Guymer Emma K. , Littlejohn Geoffrey O. , Rasker Johannes J. 
Published: August 2019

Objective.To investigate the relation of physical (non-psychological) comorbidity and multimorbidity to quantitative measures of fibromyalgia (FM) and musculoskeletal pain.Methods.We studied 12,215 patients in a research databank with quantitative measures of FM-related variables (FMV) that included binary determinations of FM and widespread pain (WSP), and constituent variables of FM diagnosis that included the WSP index (WPI), the symptom severity score (SSS), and the polysymptomatic distress scale (PSD). We assessed self-reported comorbid conditions and covariates that included age, sex, body mass index, hypertension, smoking history, and total household income. We used nearest-neighbor matching and regression adjustment treatment effects models to measure the effect of comorbidities on FMV.Results.We found a positive association between FMV and the probability of having each comorbid condition. Patients with ≥ 1 comorbidities had PSD, WPI, and SSS increases of 3.0 (95% CI 2.7–3.3), 1.8 (95% CI 1.6–2.0), and 1.2 (95% CI 1.1–1.3) units, respectively, and an increase in FM prevalence from 20.4% to 32.6%. As the number of comorbid conditions present increased from 1 to 4 or more, PSD, WPI, SSS, and FM percent increased stepwise. For patients with ≥ 4 conditions, the predicted prevalence of FM was 55.2%.Conclusion.FM and FMV are associated with an increase in the number of comorbidities, and the association can be measured quantitatively. However, the association of WSP and FM may be an effect of definitions of WSP and FM, because comorbidity increases are also present with subsyndromal levels of both conditions.
Anatomie du discours de lancement
Authors: Luneau Marie-Pier , Mailhot Virginie 
Published: August 2019

Entre 1950 et 1970, les lancements de livres sont fréquents aux Éditions Fides. À chaque événement, le père Paul-Aimé Martin, fondateur de la maison, ne manque pas de prendre la parole. Éditeur aguerri, grand érudit et fin publiciste, le père Martin manifeste une énonciation éditoriale particulière à travers ses allocutions de lancement. Censé s’effacer devant l’auteur, de quoi parle exactement l’éditeur à ce moment où il chante les louanges de telle nouveauté? Cet article vise à jeter les prémisses d’une réflexion sur un type particulier de « discours » d’éditeur, soit l’allocution prononcée lors de lancements. Au-delà d’une certaine part de flagornerie consubstantielle à ce type d’énoncé, comment l’éditeur parvient-il à mettre en valeur son propre catalogue? Il s’agit d’observer quelles stratégies discursives déploie l’éditeur dans ce type d’énoncé, et quels rapports de force le sous-tendent.
Les éditeurs d’Afrique francophone sur l’échiquier du « glocal » (1980-2019)
Authors: Thierry Raphaël 
Published: August 2019

Entre les langues, les marchés et les labels, l’édition africaine représente un objet constant de discours. Celle-ci interroge en permanence notre regard sur le livre et notre relation à l’offre éditoriale internationale. Le temps est désormais révolu où le discours quasi unique concernant l’édition en Afrique portait sur la prétendue « famine du livre » continentale liée à la crise économique des années 1980. Depuis trois décennies, les marchés du livre n’ont fait que croître sur le continent, diversifiant leur production à travers une circulation des livres et de l’information éditoriale toujours plus intensives et transnationales. L’édition africaine demeure toutefois bien souvent présentée à travers les difficultés rencontrées par ses agents plutôt que, précisément, leur capacité d’agentivité (« Agency »). Indiscutable, historiquement établi, le livre africain se fait pourtant le miroir de la globalisation éditoriale et de ses flux économiques. Les enjeux économiques qui y ont cours reflètent alors les inégalités, les alternatives – les marges, aussi – d’un monde du livre toujours davantage concentré. L’édition africaine participe de même à un double questionnement : en Afrique, elle doit défendre sa légitimité économique et intellectuelle en fonction de contextes sociopolitiques évolutifs et de marchés éducatifs en situation d’extraversion; à l’international, elle doit se positionner vis-à-vis de l’édition non africaine de littérature et de non-fiction qui concentre la majorité de la production intellectuelle africaine dans le monde. En étudiant les discours sur le livre africain, discours d’éditeurs africains et évolution du marché international du livre africain francophone depuis les années 1980, cette réflexion se propose d’interroger la relation entre l’industrie du livre en Afrique et le phénomène de mondialisation du livre, afin de mettre au jour un tissu permanent d’échanges, de tensions et d’influences, faisant du marché du livre africain un espace « glocal », s’il en est.
André Schiffrin et Éric Hazan, emblèmes d’une radicale indépendance
Authors: Lefort-Favreau Julien 
Published: August 2019

Cet article examine le discours élaboré par l’éditeur André Schiffrin durant les années 2000. Nous observerons la transformation d’un discours éditorial : les textes de Schiffrin, de mémoires autobiographiques, acquièrent une portée politique, au point même de devenir manifestes de l’édition indépendante. Le discours de réception qui se cristallise autour des propos de Schiffrin éclaire par ailleurs un second discours, celui de son propre éditeur, Éric Hazan, le fondateur de La Fabrique. À partir de l’analyse croisée des positions objectives de Schiffrin dans le champ et de leur parole respective, nous proposerons une définition de la notion d’indépendance éditoriale. C’est le portrait d’un écosystème éditorial en mutation que nous brossons, en soulignant l’importance des discours d’éditeurs dans la politisation de leur métier au tournant du millénaire. Ultimement, nous mettrons au jour le rôle de ces discours dans la mise en place d’une guerre de position qui vise à fissurer une hégémonie culturelle.
ViSiElse: An innovative visualization R package to ensure behavioral raw data reliability and transparency
Authors: Garnier Elodie Marie , Fouret Nastasia , Descoins Médéric 
Published: August 2019

Background. In recent years, the scientific community encouraged the use of raw data graphs to improve the reliability and transparency of the results presented in papers. However, methods to visualize raw data are limited to one variable per graph and/or only small samples. In behavioral science as in many other fields, multiple variables need to be plotted together to allow insights of the behavior or the process observations. In this paper, we present ViSiElse, an R-package offering a new approach in raw data visualization.
Methods. ViSiElse was developed with the open-source software R to provide a solution for the complete visualization of the raw time data.
Results. ViSiElse grants a global overview of a process by combining the visualization of multiple actions timestamps for all participants in a single graph. Individuals and/or group behavior can easily be assessed. Supplementary features allow users to further inspect their data by adding statistical indicators and/or time constraints. ViSiElse provides a global visualization of actions acquired from timestamps in any quantifiable observations.
Lean healthcare integrated with discrete event simulation and design of experiments: an emergency department expansion
Authors: Gabriel Gustavo Teodoro , Campos Afonso Teberga , Magacho Aline de Lima , Segismondi Lucas Cavallieri , Vilela Flávio Fraga , de Queiroz Jose Antonio , Montevechi José Arnaldo Barra 
Published: August 2019

Background. Discrete Event Simulation (DES) and Lean Healthcare are management tools that are efficient and assist in the quality and efficiency of health services. In this sense, the purpose of the study is to use lean principles jointly with DES to plan the expansion of a Canadian emergency department and to the demand that comes from small closed care centers.
Methods. For this, we used simulation and modeling method. We simulated the emergency department in FlexSim Healthcare® software and, with the Design of Experiments (DoE), we defined the optimal number of locations and resources for each shift.
Results. The results show that the ED cannot meet expected demand in the current state. Only 17.2% of the patients were completed treated, and the Length of Stay (LOS), on average, was 2213.7, with a confidence interval of (2131.8 - 2295.6) minutes. However, after changing decision variables, the number of treated patients increased to 95.7% (approximately 600%). Average LOS decreased to 461.2, with a confidence interval of (453.7 - 468.7) minutes, about 79.0%. In addition, the study shows that emergency department staff are balanced, according to Lean principles.
Complexity of human walking: the attractor complexity index is sensitive to gait synchronization with visual and auditory cues
Authors: Terrier Philippe 
Published: August 2019

Background
During steady walking, gait parameters fluctuate from one stride to another with complex fractal patterns and long-range statistical persistence. When a metronome is used to pace the gait (sensorimotor synchronization), long-range persistence is replaced by stochastic oscillations (anti-persistence). Fractal patterns present in gait fluctuations are most often analyzed using detrended fluctuation analysis (DFA). This method requires the use of a discrete times series, such as intervals between consecutive heel strikes, as an input. Recently, a new nonlinear method, the attractor complexity index (ACI), has been shown to respond to complexity changes like DFA, while being computed from continuous signals without preliminary discretization. Its use would facilitate complexity analysis from a larger variety of gait measures, such as body accelerations. The aim of this study was to further compare DFA and ACI in a treadmill experiment that induced complexity changes through sensorimotor synchronization.

Methods
Thirty-six healthy adults walked 30 min on an instrumented treadmill under three conditions: no cueing, auditory cueing (metronome walking), and visual cueing (stepping stones). The center-of-pressure trajectory was discretized into time series of gait parameters, after which a complexity index (scaling exponent alpha) was computed via DFA. Continuous pressure position signals were used to compute the ACI. Correlations between ACI and DFA were then analyzed. The predictive ability of DFA and ACI to differentiate between cueing and no-cueing conditions was assessed using regularized logistic regressions and areas under the receiver operating characteristic curves (AUC).

Results
DFA and ACI were both significantly different among the cueing conditions. DFA and ACI were correlated (Pearson’s r = 0.86). Logistic regressions showed that DFA and ACI could differentiate between cueing/no cueing conditions with a high degree of confidence (AUC = 1.00 and 0.97, respectively).

Conclusion
Both DFA and ACI responded similarly to changes in cueing conditions and had comparable predictive power. This support the assumption that ACI could be used instead of DFA to assess the long-range complexity of continuous gait signals. However, future studies are needed to investigate the theoretical relationship between DFA and ACI.
Retracted: Down‐regulation of long noncoding RNA PVT1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via microRNA‐145‐mediated inhibition of FSCN1
Authors: Shen Si‐Ning , Li Ke , Liu Ying , Yang Cheng‐Liang , He Chun‐Yu , Wang Hao‐Rang 
Published: August 2019

Accumulating evidence has established that long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) is a tumor regulator in many cancers. Here, we aimed to investigate the possible function of lncRNA PVT1 in esophageal carcinoma (EC) via targeting of microRNA‐145 (miR‐145). Initially, microarray‐based gene expression profiling of EC was employed to identify differentially expressed genes. Moreover, the expression of lncRNA PVT1 was examined and the cell line presenting with the highest level of lncRNA PVT1 expression was selected for subsequent experiments. We then proceeded to examine interaction among lncRNA PVT1, FSCN1, and miR‐145. The effect of lncRNA PVT1 on viability, migration, invasion, apoptosis, and tumorigenesis of transfected cells was examined with gain‐of‐function and loss‐of‐function experiments. We observed that lncRNA PVT1 was robustly induced in EC. lncRNA PVT1 could bind to miR‐145 and regulate its expression, and FSCN1 is a target gene of miR‐145. Overexpression of miR‐145 or silencing of lncRNA PVT1 was revealed to suppress cell viability, migration, and invasion abilities, while also stimulating cell apoptosis. Furthermore, our in vivo results showed that overexpression of miR‐145 or silencing of lncRNA PVT1 resulted in decreased tumor growth in nude mice. In conclusion, our research reveals that down‐regulation of lncRNA PVT1 could potentially promote expression of miR‐145 to repress cell migration and invasion, and promote cell apoptosis through the inhibition of FSCN1. This highlights the potential of lncRNA PVT1 as a therapeutic target for EC treatment.
A Site‐Specific Charge Carrier Control in Monolithic Integrated Amorphous Oxide Semiconductors and Circuits with Locally Induced Optical‐Doping Process
Authors: Kim Kyung‐Tae , Jeon Seong‐Pil , Lee Woobin , Jo Jeong‐Wan , Heo Jae Sang , Kim Insoo , Kim Yong‐Hoon , Park Sung Kyu 
Published: August 2019

AbstractAmorphous oxide semiconductor (AOS) thin film transistors (TFTs) have found cutting‐edge applications in sensor technologies. To reduce manufacturing costs, sensors, analog front end, and digital signal processing circuits need to be integrated on the identical substrate. Unlike traditional silicon‐based devices, optimizations for locally controllable electrical parameters of the AOSs have rarely been investigated. Here, photoactivated combustion reduction is utilized as doping motivation for solution‐processed amorphous indium–gallium–zinc oxide (a‐IGZO) to tune their electrical performance. By controlling parameters of a‐IGZO TFTs, which can be partly doped with covering the desired area of the identical substrate, it is possible to match the particular threshold voltage for various circuits. For circuit optimization, automatic integrated circuit modeling spice is carried out to find the best match of the complementary metal–oxide semiconductor circuits. Finally, the site‐specific performance of switching TFTs, amplifiers, and ring oscillators implemented with low‐temperature solution‐processed a‐IGZO and p‐type single‐walled carbon nanotube TFTs is demonstrated. The optical‐doped a‐IGZO TFTs exhibiting a saturation mobility of >9.15 cm2 V−1 s−1 with a locally tunable threshold voltage of −5 – 1.5 V are realized, enabling monolithic integration of functional devices. The resultant circuits demonstrate excellent amplification of 24 dB and an oscillation frequency of 12 kHz for 7‐stage ring oscillators.
Manganese‐Catalysed C−H Activation: A Regioselective C−H Alkenylation of Indoles and other (hetero)aromatics with 4‐Hydroxy‐2‐Alkynoates Leading to Concomitant Lactonization
Authors: Kumar Anil , Muniraj Nachimuthu , Prabhu Kandikere Ramaiah 
Published: August 2019

AbstractA manganese‐catalyzed C−H bond alkenylation of indoles at C2‐position with 4‐hydroxy‐2‐alkynoates leading to concomitant lactonization under removable directing group strategy has been disclosed. This lactonization strategy exhibits regioselectivity, a broad substrate scope, and a good functional group tolerance furnishing the products in low to high yields. The regioselectivity is guided by the electronic effect of the ester group as well as the steric bulk at the C4‐position of the 4‐hydroxy‐2‐alkynoates. After the reaction, the directing group has been readily removed to obtain N−H free indole.magnified image
Wood‐Derived Nanofibrillated Cellulose Hydrogel Filters for Fast and Efficient Separation of Nanoparticles
Authors: Wang Yushu , Wang Jialiang , Ling Shengjie , Liang Haiwei , Dai Ming , Bai Lulu , Li Qing , Fan Zhuangjun , Lee Sang‐Young , Yu Haipeng , Liu Shouxin , Wang Qingwen , Liu Yixing , Li Jian , Sun Tianmeng , Chen Wenshuai 
Published: August 2019

AbstractFast water permeable filters with an efficient rejection ratio are desirable for nanoparticle separation and water/air purification. Ultrathin nanoporous filters are effective because of their features, including narrow and tunable pore size distributions capable of handling a high solvent flux. However, it remains challenging to develop antifouling filters that maintain a stable flux with high rejection efficiency over long‐term filtration of nanoparticle solutions. Here, a facile and low‐cost approach is reported to fabricate biocompatible hydrogel filters with interconnected nanofiber network structures through the use of high aspect ratio, wood‐derived nanofibrillated cellulose (NFC). The super‐hydrophilia and high porosity of these materials endow the NFC hydrogel filters (NFC‐HFs) with high solvent permeance. Nanofibrous networks and interconnected nanoporous structures of NFC‐HFs promote efficient rejection and precise size‐selective separation of nanoparticles. Specifically, small and irregular nanopores of NFC‐HFs fail to match the size of relatively large nanoparticles, which ensures a relatively stable flux of the NFC‐HFs over the whole filtration process, even under continuous filtration of highly concentrated nanoparticle solutions.
Technoeconomic Mixed Integer Nonlinear Programming (MINLP) optimization for design of Liquid‐Liquid Extraction (LLE) cascades in continuous pharmaceutical manufacturing of atropine
Authors: Diab Samir , Gerogiorgis Dimitrios I. 
Published: August 2019

AbstractContinuous Pharmaceutical Manufacturing (CPM) offers operational and economic benefits over the currently dominant methods implemented by industry. The demonstrated continuous flow synthesis of atropine facilitates modeling and optimization of its upstream continuous manufacturing. This study implements MINLP optimization of a continuous Liquid‐Liquid Extraction (LLE) flowsheet superstructure for total cost minimization of an upstream atropine CPM plant. The steady‐state process model considers reactor design from regressed kinetic parameters including investigation of maximum allowable PFR reactor dimensions to maximize the benefits of API flow synthesis. Continuous LLE modeling considers solute partitioning between phases, UNIFAC‐modeled liquid–liquid equilibria and mass transfer correlations for LLE design. Optimal LLE design configurations from the considered superstructure require fresh solvent added to the first vessel in co‐current flow in addition to the countercurrent flow in the cascade. Optimization results indicate toluene as the best solvent choice, with total costs of 3.944 × 106 GBP for a plant capacity of 103 kg API year−1.
Non‐coalescence behavior of neutral droplets suspended in oil under a direct current electric field
Authors: Huang Xin , He Limin , Luo Xiaoming , Yin Haoran , Yang Donghai 
Published: August 2019

AbstractThe excessive electric field gives rise to droplet non‐coalescence and droplet chains in the electric dehydrator, which severely deteriorates oil–water separation efficiency and even leads to short circuit. To reveal the underlying mechanism of droplet non‐coalescence, dynamic behavior of two neutral droplets in silicone oil under a direct current electric field is investigated by using high‐speed photography. The experimental results show that there exists a critical electric field strength above which two droplets will bounce off after the contact. The critical electric field strength of droplet non‐coalescence is affected by the initial separation distance between droplets, the radius of droplet, and the surfactant concentration. Whether the non‐coalescence behavior occurs in the electric field is determined by the competition of electric force and capillary force, which dominates the evolution of tiny connection channel.