bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collateral damage of using colistin in hospitalized patients on emergence of colistin-resistant Escherichia coli and Klebsiella pneumoniae colonization and infection
Authors: Wangchinda W. , Pati N. , Maknakhon N. , Seenama C. , Tiengrim S. , Thamlikitkul V. 
Published: July 2018

Abstract
Background
Colistin has been used for therapy of carbapenem-resistant Gram-negative infections in Thailand, especially carbapenem-resistant A. baumannii and P. aeruginosa, for more than 10 years. However, the prevalence of colistin-resistant A. baumannii or P. aeruginosa is still less than 5%. Colistin-resistant Enterobacteriaceae has been increasingly reported globally over the past few years and the use of colistin in food animals might be associated with an emergence of colistin resistance in Enterobacteriaceae. This study aimed to determine the effect of colistin exposure in hospitalized patients who received colistin on development of colistin-resistant (CoR) Escherichia coli (EC) or Klebsiella pneumoniae (KP) colonization and infection.

Methods
A prospective observational study was performed in adult hospitalized patients at Siriraj Hospital who received colistin for treatment of infections during December 2016 and November 2017. The surveillance culture samples were collected from the stool and the site of infection of each patient who received colistin at the study enrollment, days 3 and 7 after the study enrollment, and once a week thereafter for determination of CoR EC and CoR KP. CoR EC and CoR KP were also tested for a presence of mcr-1 gene.

Results
One hundred thirty-nine patients were included. Overall prevalence of CoR EC or CoR KP colonization was 47.5% among 139 subjects. Prevalence of CoR EC or CoR KP colonization was 17.3% of subjects at study enrollment, and 30.2% after study enrollment. Use of fluoroquinolones, aminoglycosides, and colistin was found to be significantly associated with CoR EC or CoR KP colonization. The mcr-1 gene was detected in 13.0% of CoR EC or CoR KP isolates, and in 27.3% of subjects with CoR EC or CoR KP colonization. CoR EC or CoR KP colonization persisted in 65.2% of the subjects at the end of the study. Five patients with CoR KP infections received combination antibiotics and they were alive at hospital discharge.

Conclusions
Prevalence of CoR EC or CoR KP colonization in hospitalized patients receiving colistin was high and it was associated with the use of colistin. Therefore, patients who receive colistin are at risk of developing CoR EC or CoR KP colonization and infection.
The Association of Thyroid Function With Bone Density During Childhood
Authors: Veldscholte Karlien , Barjaktarovic Mirjana , Trajanoska Katerina , Jaddoe Vincent W V , Visser Theo J , de Rijke Yolanda B , Peeters Robin P , Rivadeneira Fernando , Korevaar Tim I M 
Published: July 2018

AbstractContextAlthough the skeleton is a well-known thyroid hormone target organ, very little data are available on the association of thyroid function with bone outcomes during childhood.ObjectiveTo study the association of thyroid function with bone mass during childhood.Design, Setting, and ParticipantsPopulation-based prospective cohort including 4204 children with TSH and free T4 (FT4) measured at the age of 6 years.Main Outcome MeasuresBone density was assessed by a total body dual-energy X-ray absorptiometry scan at the median age of 6 years (95% range, 5.6 to 7.9) and at the age of 10 years (95% range, 9.0 to 10.9) in 4204 and 3404 participants, respectively.ResultsThere was an inverse association of TSH with bone mineral density (BMD) at the age of 6 (β −0.028 ± 0.011, P = 0.009) and with follow-up measurements at the age of 10 (β −0.027 ± 0.011, P = 0.014), but not with bone mineral content (BMC) at the age of 6 (β −0.028 ± 0.015, P = 0.06) or for follow-up measurements of BMC at the age of 10 (β −0.011 ± 0.015, P = 0.47). There was an inverse association of FT4 with BMD (β −0.016 ± 0.006, P = 0.014) and BMC (β −0.023 ± 0.009, P = 0.009) cross-sectionally, and also at the age of 10 years (BMD: β −0.018 ± 0.007, P = 0.007; BMC: β −0.021 ± 0.009, P = 0.020).ConclusionA higher FT4 concentration is associated with lower bone mass at the age of 6 and at the age of 10 years. These data provide insights into the effects of thyroid function on bone physiology during childhood.
Differences in Upper and Lower Body Adipose Tissue Oxygen Tension Contribute to the Adipose Tissue Phenotype in Humans
Authors: Vogel Max A A , Jocken Johan W E , Sell Henrike , Hoebers Nicole , Essers Yvonne , Rouschop Kasper M A , Čajlaković Merima , Blaak Ellen E , Goossens Gijs H 
Published: July 2018

Abstract

Context and Objectives
Upper and lower body adipose tissue (AT) exhibits opposing associations with obesity-related cardiometabolic diseases. Recent studies have suggested that altered AT oxygen tension (pO2) may contribute to AT dysfunction. Here, we compared in vivo abdominal (ABD) and femoral (FEM) subcutaneous AT pO2 in women who are overweight and have obesity, and investigated the effects of physiological AT pO2 on human adipocyte function.

Design
ABD and FEM subcutaneous AT pO2 and AT blood flow (ATBF) were assessed in eight [BMI (body mass index) 34.4 ± 1.6 kg/m2] postmenopausal women who were overweight with obesity and impaired glucose metabolism. ABD and FEM AT biopsy specimens were collected to determine adipocyte morphology and AT gene expression. Moreover, the effects of prolonged exposure (14 days) to physiological AT pO2 on adipokine expression/secretion, mitochondrial respiration, and glucose uptake were investigated in differentiated human multipotent adipose-derived stem cells.

Results
AT pO2 was higher in ABD than FEM AT (62.7 ± 6.6 vs 50.0 ± 4.5 mm Hg, P = 0.013), whereas ATBF was comparable between depots. Maximal uncoupled oxygen consumption rates were substantially lower in ABD than FEM adipocytes for all pO2 conditions. Low physiological pO2 (5% O2) decreased proinflammatory gene expression, increased basal glucose uptake, and altered adipokine secretion in ABD and FEM adipocytes.

Conclusions
We demonstrated for the first time, to our knowledge, that AT pO2 is higher in ABD than FEM subcutaneous AT in women who are overweight/with obesity, partly due to a lower oxygen consumption rate in ABD adipocytes. Moreover, low physiological pO2 decreased proinflammatory gene expression and improved the metabolic phenotype in differentiated human adipocytes, whereas more heterogeneous effects on adipokine secretion were found.
Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection vs. Insulin Alone in Type 2 Diabetes
Authors: Mather Kieren J , Considine Robert V , Hamilton LaTonya , Patel Niral A , Mathias Carla , Territo Wendy , Goodwill Adam G , Tune Johnathan D , Green Mark A , Hutchins Gary D 
Published: July 2018

Abstract

Context
It is unclear if effects of glucagon-like peptide-1 (GLP-1) and clinically available GLP-1 agonists on the heart occur at clinical doses in humans, possibly contributing to reduced cardiovascular disease risk.

Objective
To determine whether liraglutide, at clinical dosing, augments myocardial glucose uptake (MGU) alone or combined with insulin compared with insulin alone in metformin-treated type 2 diabetes mellitus (T2D).

Design
In a randomized clinical trial of patients with T2D treated with metformin plus oral agents or basal insulin, myocardial fuel use was compared after 3 months of treatment with insulin detemir, liraglutide, or combination detemir plus liraglutide added to background metformin.

Main Outcome Measures
Myocardial blood flow (MBF), fuel selection, and rates of fuel use were evaluated using positron emission tomography, powered to demonstrate large effects.

Results
MBF was greater in the insulin-treated groups [median (25th, 75th percentile): detemir, 0.64 mL/g/min (0.50, 0.69); liraglutide, 0.52 mL/g/min (0.46, 0.58); detemir plus liraglutide, 0.75 mL/g/min (0.55, 0.77); P = 0.035 comparing three groups, P = 0.01 comparing detemir groups to liraglutide alone]. There were no evident differences among groups in MGU [detemir, 0.040 µmol/g/min (0.013, 0.049); liraglutide, 0.055 µmol/g/min (0.019, 0.105); detemir plus liraglutide, 0.037 µmol/g/min (0.009, 0.046); P = 0.68 comparing three groups]. There were no treatment-group differences in measures of myocardial fatty acid uptake or handling, and no differences in total oxidation rate.

Conclusion
These observations argue against large effects of GLP-1 agonists on myocardial fuel metabolism as mediators of beneficial treatment effects on myocardial function and ischemia protection.
Dissecting recipient from donor contribution in experimental kidney transplantation: focus on endothelial proliferation and inflammation
Authors: Papazova Diana A. , Krebber Merle M. , Oosterhuis Nynke R. , Gremmels Hendrik , van Zuilen Arjan D. , Joles Jaap A. , Verhaar Marianne C. 
Published: July 2018

ABSTRACT
Kidney transplantation (Tx) is considered the only definite treatment for end-stage kidney disease (ESKD) patients. The increasing prevalence of ESKD has necessitated the introduction of transplantation with kidneys from suboptimal donors. There is, however, still a lack of fundamental and longitudinal research on suboptimal kidney transplants. Specifically, there is a demand for accurate pre-Tx predictors of donor kidney function and injury to predict post-Tx outcome. In the present study, we combine rat models of chronic kidney disease (CKD) and renal Tx to dissect the effects of healthy and CKD renal grafts on healthy and CKD recipients. We show that renal function at 6 weeks post-Tx is exclusively determined by donor graft quality. Using cell tracking within enhanced green fluorescent protein-positive (eGFP+) recipients, we furthermore show that most inflammatory cells within the donor kidney originate from the donor. Oxidative and vascular extra-renal damage were, in contrast, determined by the recipient. Post- versus pre-Tx evaluation of grafts showed an increase in glomerular and peritubular capillary rarefaction in healthy but not CKD grafts within a CKD environment. Proliferation of glomerular endothelium was similar in all groups, and influx of eGFP+ recipient-derived cells occurred irrespective of graft or recipient status. Glomerular and peritubular capillary rarefaction, severity of inflammation and macrophage subtype data post-Tx were, however, determined by more complicated effects, warranting further study. Our experimental model could help to further distinguish graft from recipient environment effects, leading to new strategies to improve graft survival of suboptimal Tx kidneys.
This article has an associated First Person interview with the first author of the paper.
Acromioclavicular joint injuries: diagnosis, classification and ligamentoplasty procedures
Authors: Sirin Evrim , Aydin Nuri , Mert Topkar Osman 
Published: July 2018

Acromioclavicular (AC) joint injury is a frequent diagnosis after an acute shoulder trauma – often found among athletes and people involved in contact sports. This injury occurs ﬁve times more frequently in men than in women, with the highest incidence in the 20- to 30-year-old age group. Patients usually complain of pain and tenderness over the shoulder, particularly over the AC joint. Depending on the degree of injury, the clavicle may become prominent on the injured site. The original classification was described by Rockwood and Green according to the injured ligament complex and degree and direction of clavicular displacement. Many surgical procedures have been described; among these are screws, plates, muscle transfer, ligamentoplasty procedures and ligament reconstruction using either autograft or allografts. With the advancement of shoulder arthroscopy, surgeons are much more capable of performing mini-open or arthroscopically-assisted procedures, allowing patients an earlier return to their daily living activities. However, the results of conventional open techniques are still comparable. The introduction of new arthroscopic equipment provides a great variety of surgical procedures, though every new technique has its own advantages and pitfalls. Currently there is no gold standard for the surgical treatment of any type of AC injury, though it should be remembered that whenever an arthroscopic technique is chosen, the surgeon’s expertise is likely to be the most significant factor affecting outcome. Cite this article: EFORT Open Rev 2018;3:426-433. DOI: 10.1302/2058-5241.3.170027
Nineteenth Century Navies Role in Developing an understanding of the Pacific Coast of Central America
Authors: León Sáenz Jorge 
Published: July 2018

Navies, apart from their traditional use by nations as instruments for the projection of power, for the protection of maritime interests and for exercising peacekeeping and war activities, have also had an important role in developing scientific and technical knowledge. The survey work undertaken by various navies since the 18th century, has in particular been of great benefit in improving and making navigation safer on high seas and coasts, through the provision of maritime charts and sailing directions, to all mariners. The technical efforts and geopolitical interests behind those efforts in the 19th century and how they affected the maritime trade and foreign affairs of the Central American countries located on the Pacific Coast are the subject of this study.
Wavelength Shift Measurement Method Without Use of Spectrometer: The New Way for Environment Photonic Sensors
Authors: Hoi Pham Van , Van Nguyen Thuy , Dai Pham Van , Thang Le Huu , An Nguyen Van , Binh Pham Thanh 
Published: July 2018

The photonic sensors have shown very effectively for measuring the toxic contents in the liquid and air environments. In principle, the photonic sensors based on measurement of wavelength shift between reference condition and testing environments that we need use the spectrometer with high cost. In this paper, we present new configurations of photonic devices for measuring wavelength shift without use of spectrometer, which has a large potential for application in sensing technique with low cost. There are two configurations of photonic sensors are presented: i) first of them is based on fiber Bragg grating (FBG) combined with DFB laser diode with controlling wavelength emission by laser temperature and ii) second one is used the fiber ring laser from Erbium-doped fiber and two FBG operated as reference and sensing probe. The etched-fiber Bragg grating (e-FBG) as sensing probe is suitable for bio- and/ or chemical sensors. A novel photonic sensor can increase sensitivity and measuring accuracy of device by the narrow line-width of reflection spectra from laser and the sensor can determine a refractive index variation of 2x10-4, which is similarly for high resolution spectrometer. The experimental results show that this sensing method could determine different mixing ratios of organic solvents in liquid environment with good repeatability, high accuracy and rapid response.Keywords:
CONSISTENCY IN ASSESSING PHYSICAL DEVELOPMENT OF CHILDREN WITH CEREBRAL PALSY ACCORDING TO REGIONAL AND SPECIALIZED CENTILE SCALES: A POPULATION-BASED CROSS-SECTIONAL STUD
Authors: Kovtun Olga P. , Plaksina Anna N. , Dugina Elena A. 
Published: July 2018

Background.Children with infantile cerebral palsy (ICP) often have a physical developmental delay due to protein-energy malnutrition (PEM). The assessment of such abnormalities using different centile scales may lead to inconsistent results.Objective.Our aim was to study the consistency in assessing physical development of children with ICP using regional and specialized centile scales.Methods.The assessment of physical development with determination of the proportion of patients with PEM (weight-age and/or heightage values < 10th percentile) was carried out using regional centile scales and the Life Expectancy Project scales taking into account motor disorder levels (I–V) according to GMFCS. The assessment of motor disorders was performed by neurologists of healthcare organizations in 54 municipalities of the Sverdlovsk Region. The accounting period was from September 2016 to January 2017.Results.According to regional centile scales, PEM was identified in 272 (35.7%) children; according to the Life Expectancy Project scales — in 56 (7.4%) out of 761 children with ICP (McNemar's criterion, p < 0.001). Using regional scales the following results were registered: children with GMFCS I had PEM 5 times less than children with GMFCS V — 10 (12.5%) and 107 (66%) cases, respectively (ꭓ2criterion, p < 0.001). When assessing physical development of children with specialized scales, PEM occurred in 4 (5%) patients with GMFCS I and 18 (11.1%) with GMFCS V (p < 0.001).Conclusion.Specialized scales for assessing physical development less often indicate the presence of PEM in children with ICP. When using regional and to a much lesser extent specialized centile scales, the detection rate for PEM cases depends on the level of motor disorders.
Impact of Patient Age on Molecular Alterations of Left-Sided Colorectal Tumors
Authors: Puccini Alberto , Lenz Heinz-Josef , Marshall John L. , Arguello David , Raghavan Derek , Korn W. Michael , Weinberg Benjamin A. , Poorman Kelsey , Heeke Arielle L. , Philip Philip A. , Shields Anthony F. , Goldberg Richard M. , Salem Mohamed E. 
Published: July 2018

Abstract

Background
The incidence of colorectal cancer (CRC) in younger patients is rising, mostly due to tumors in the descending colon and rectum. Therefore, we aimed to explore the molecular differences of left-sided CRC between younger (≤45 years) and older patients (≥65).

Subjects, Materials, and Methods
In total, 1,126 CRC tumor samples from the splenic flexure to (and including) the rectum were examined by next-generation sequencing (NGS), immunohistochemistry, and in situ hybridization. Microsatellite instability (MSI) and tumor mutational burden (TMB) were assessed by NGS.

Results
Younger patients (n = 350), when compared with older patients (n = 776), showed higher mutation rates in genes associated with cancer-predisposing syndromes (e.g., Lynch syndrome), such as MSH6 (4.8% vs. 1.2%, p = .005), MSH2 (2.7% vs. 0.0%, p = .004), POLE (1.6% vs. 0.0%, p = .008), NF1 (5.9% vs. 0.5%, p &lt; .001), SMAD4 (14.3% vs. 8.3%, p = .024), and BRCA2 (3.7% vs. 0.5%, p = .002). Genes involved in histone modification were also significantly more mutated: KDM5C (1.9% vs. 0%, p = .036), KMT2A (1.1% vs. 0%, p = .033), KMT2C (1.6% vs. 0%, p = .031), KMT2D (3.8% vs. 0.7%, p = .005), and SETD2 (3.2% vs. 0.9%, p = .039). Finally, TMB-high (9.7% vs. 2.8%, p &lt; .001) and MSI-high (MSI-H; 8.1% vs. 1.9%, p = .009) were more frequent in younger patients.

Conclusion
Our findings highlight the importance of genetic counseling and screening in younger CRC patients. MSI-H and TMB-high tumors could benefit from immune-checkpoint inhibitors, now approved for the treatment of MSI-H/deficient mismatch repair metastatic CRC patients. Finally, histone modifiers could serve as a new promising therapeutic target. With confirmatory studies, these results may influence our approach to younger adults with CRC.
FDA Supplemental Approval: Blinatumomab for Treatment of Relapsed and Refractory Precursor B-Cell Acute Lymphoblastic Leukemia
Authors: Pulte E. Dianne , Vallejo Jonathon , Przepiorka Donna , Nie Lei , Farrell Ann T. , Goldberg Kirsten B. , McKee Amy E. , Pazdur Richard 
Published: July 2018

Abstract

On July 11, 2017, the Food and Drug Administration granted approval for blinatumomab for the treatment of relapsed or refractory (R/R) precursor B-cell acute lymphoblastic leukemia (ALL). Blinatumomab is a bispecific CD19-directed CD3 T-cell engager. The basis for the approval included results from two clinical trials, TOWER and ALCANTARA. TOWER, a randomized trial comparing overall survival in patients with Philadelphia chromosome (Ph)-negative R/R ALL receiving blinatumomab versus standard-of-care (SOC) chemotherapy, demonstrated a hazard ratio of 0.71 favoring blinatumomab (p = .012; median survival, 7.7 months with blinatumomab and 4.0 months with SOC chemotherapy). Complete remission (CR) rates were 34% for patients receiving blinatumomab and 16% for those receiving SOC. Adverse events were consistent with those observed in prior trials, with cytokine release syndrome and some neurologic events, including tremor, encephalopathy, peripheral neuropathy, and depression, observed more frequently in the blinatumomab arm, whereas neutropenia and infection were less common among patients receiving blinatumomab. Depression emerged as a rare but potentially severe neurologic event associated with blinatumomab. In ALCANTARA, a single-arm trial of blinatumomab in patients with Ph-positive R/R ALL, the CR rate was 31%, and adverse events were similar to those observed previously in Ph-negative R/R ALL. These results support conversion from accelerated to regular approval of blinatumomab for R/R ALL and broadening of the intended population to include both Ph-positive and Ph-negative precursor B-cell R/R ALL.

Implications for Practice
In TOWER, a randomized trial in patients with relapsed or refractory Philadelphia chromosome (Ph)-negative precursor B-cell acute lymphoblastic leukemia (ALL), treatment with blinatumomab showed superiority over conventional chemotherapy for complete remission (CR) rate (34% vs. 16%) and survival (3.7-month improvement in median; hazard ratio, 0.71). In ALCANTARA, a single-arm trial of blinatumomab for treatment of relapsed or refractory Ph-positive precursor B-cell ALL, the CR rate was 31%. Blinatumomab is now approved for treatment of relapsed or refractory precursor B-cell ALL that is Ph positive or Ph negative.