bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probable Roles of Coagulation Cascade and Fibrinolysis System in the Development of Allergic Rhinitis
Authors: Hong Seung-No , Zhang Yu-Lian , Rhee Chae-Seo , Kim Dong-Young 
Published: December 2018

Background Dysregulation of the coagulation cascade and fibrinolysis system may play an etiologic role in many diseases. Allergic diseases such as bronchial asthma, atopic dermatitis, and conjunctivitis are also associated with fibrin accumulation caused by a change in hemostasis. However, only a few studies have dealt with the relationship between allergic rhinitis (AR) and the coagulation system. Objective We investigated the difference of coagulation and fibrinolysis cascade components between an AR mouse model and a control mice. Methods BALB/c mice were sensitized and challenged with ovalbumin. Multiple parameters of coagulation cascade and fibrinolysis system such as factors II, V, VII, X, and XIII; tissue-type plasminogen activator; urokinase-type plasminogen activator (u-PA); plasminogen activator inhibitor-1 (PAI-1); and fibrin were compared between the AR model group and the control group. Results The symptom scores and eosinophil counts were higher in the AR group than in the control group ( P < .01). The mRNA expression level of u-PA ( P = .040) was significantly lower, and the expression levels of factor II ( P = .038) and factor X ( P = .036) were significantly higher, in the AR group. Immunohistochemical staining revealed that most of the fibrinolysis system and coagulation cascade components were localized to the epithelium, endothelium, and submucosal glands of the nasal mucosa. u-PA was downregulated in the AR group, whereas fibrin deposition was more prominent in the AR group than in the control group. Conclusion In AR, particular components of the coagulation cascade were increased and fibrinolysis system was decreased compared to normal control. This difference may be associated with the fibrin deposition in the mucosa of AR mouse model.
Reduction of multitasking distractions underlies the higher adenoma detection rate of water exchange compared to air insufflation – blinded analysis of withdrawal phase videos
Authors: Hsieh Yu-Hsi , Koo Malcolm , Tseng Chih-Wei , Yang Hsiu-Wen , Leung Felix W 
Published: December 2018

BackgroundExperts have hypothesized that a reduction of multitasking distractions and improved bowel cleanliness can explain why insertion water exchange enhances adenoma detection rate.ObjectiveThe purpose of this study was to test the role of both distractions during withdrawal and bowel cleanliness in enhancing adenoma detection rate using coded video records of colonoscopy.MethodsThe withdrawal phase of videos of 299 consecutive colonoscopies from two randomized controlled trials comparing water exchange versus air insufflation at a regional hospital in Taiwan were coded. The primary outcome was distractions; activities that preclude full attention being paid to inspection of the mucosa for polyps. A single blinded reviewer collected the data.ResultsThere were significant agreements in inter‐rater reliability indexes. Compared to air insufflation, water exchange had significantly fewer distractions; higher diagnostic yield (intervention time and number), adenoma detection rate, and Boston Bowel Preparation Scale score. Water exchange had a higher withdrawal technique score (predominantly adequacy of cleaning). The association between increased adenoma detection rate and water exchange was mediated by the number of distractions and withdrawal time, but not the Boston Bowel Preparation Scale score.ConclusionThe speculation by experts that a reduction of multitasking distractions underlies the significantly higher adenoma detection rate of water exchange is supported by the current study. Increased bowel cleanliness did not contribute to the increased adenoma detection rate by use of water exchange.
Economic burden of bronchiectasis in Germany
Authors: Diel Roland , Chalmers James D. , Rabe Klaus F. , Nienhaus Albert , Loddenkemper Robert , Ringshausen Felix C. 
Published: December 2018

Estimates of healthcare costs for incident bronchiectasis patients are currently not available for any European country.Out of a sample of 4 859 013 persons covered by German statutory health insurance companies, 231 new bronchiectasis patients were identified in 2012. They were matched with 685 control patients by age, sex and Charlson Comorbidity Index, and followed for 3 years.The total direct expenditure during that period per insured bronchiectasis patient was EUR18 634.57 (95% CI EUR15 891.02–23 871.12), nearly one-third higher (ratio of mean 1.31, 95% CI 1.02–1.68) than for a matched control (p<0.001). Hospitalisation costs contributed to 35% of the total and were >50% higher in the bronchiectasis group (ratio of mean 1.56, 95% CI 1.20–3.01; p<0.001); on average, bronchiectasis patients spent 4.9 (95% CI 2.27–7.43) more days in hospital (p<0.001). Antibiotics expenditures per bronchiectasis outpatient (EUR413.81) were nearly 5 times higher than those for a matched control (ratio of mean 4.85, 95% CI 2.72–8.64). Each bronchiectasis patient had on average 40.5 (95% CI 17.1–43.5) sick-leave days and induced work-loss costs of EUR4230.49 (95% CI EUR2849.58–5611.20). The mortality rate for bronchiectasis and matched non-bronchiectasis patients after 3 years of follow-up was 26.4% and 10.5%, respectively (p<0.001). Mortality in the bronchiectasis group was higher among those who also had chronic obstructive lung disease than in patients with bronchiectasis alone (35.9% and 14.6%, respectively; p<0.001).Although bronchiectasis is considered underdiagnosed, the mortality and associated financial burden in Germany are substantial.
Indoor air pollution impact on cultural heritage in an urban and a rural location in Romania: the National military museum in Bucharest and the Tismana monastery in Gorj County
Authors: Grøntoft Terje , Marincas Octaviana 
Published: December 2018

Abstract
Assessment was performed of the air quality related risk to the conservation of cultural heritage objects in one urban and one rural indoor location in Romania, with expected different air quality related conservation challenges: the National military museum in Bucharest and the Tismana monastery in Gorj County. The work was performed within and subsequent to the EU-Memori project by applying Memori methodology, Memori®-EWO (Early warning organic) dosimeters and passive pollution badge samplers for acetic and formic acids. The measurements in the National military museum were performed in three rooms with different exposure situations, and inside protective enclosures in the rooms. The rooms had organic and inorganic objects on exhibition and in store. The observed risks were associated with photo-oxidizing impact probably due to traffic pollutants entering from outdoor, and/or light exposure and temperature. The risks were found to be moderate, generally comparable to typical European purpose built museum locations. The highest risk was observed in a more open exhibition room in the main museum building. It was indicated that some observable change might happen to sensitive pigments and paper within 3 years, and to lead, copper and sensitive glass within 30 years in this location. Risk for observable change to sensitive pigments, paper, lead and sensitive glass within 30 years, was indicated in the other locations. The lowest risk was observed in a warehouse. A reduction in photo-oxidizing risk was measured in two of the enclosures, but a slightly higher acidic impact was measured in all the three enclosures, as compared to the respective rooms. In the Tismana monastery, a high level of acetic plus formic acid was observed in the air in the storerooms for icons and textiles, and books. Damage risk within 3 years was indicated for lead objects and sensitive glass, and within 30 years for iron and varnish (Laropal A81, resin mastic and dammar). As organic acid attack increases significantly at higher air humidity (> ~ 60%), this would be especially important to avoid. Risk for photo-oxidizing damage to paper and sensitive pigments within 30 years was indicated.
Global Access to Essential Medicines for Childhood Cancer: A Cross-Sectional Survey
Authors: Cohen Phillip , Friedrich Paola , Lam Catherine , Jeha Sima , Metzger Monika L. , Qaddoumi Ibraham , Naidu Paula , Faughnan Lane , Rodriguez-Galindo Carlos , Bhakta Nickhill 
Published: December 2018

Purpose Global data mapping access to essential chemotherapeutics for pediatric cancer are scarce. We report a survey of international pediatric cancer care providers’ access to these medicines. Methods A Web-based survey was sent to pediatric oncologists registered on the Cure4Kids Web portal. We queried chemotherapeutics in the WHO Essential Medicines List for Children, from which the average proportional availability was summarized as each country’s access score. In addition, we examined availability of drug packages defined by the WHO-sanctioned Expert Committee for eight pediatric cancers. We undertook a sensitivity analysis investigating how regimen access would change if the cytotoxics specified in recent agreements between the Clinton Health Access Initiative, American Cancer Society, and pharmaceutical companies were universally available. Results There were significant ( P < .001) differences in the median access scores between World Bank income groups, and 42.9% of respondents from low-income and lower middle–income countries reported suboptimal access scores. Our disease-based analysis revealed that 42.1% of patients in low-income and lower middle–income countries lacked full access to chemotherapy packages. Guaranteed availability of the cytotoxics specified in the Clinton Health Access Initiative/American Cancer Society agreements was projected to increase this regimen-based access by 1.6%, although including four additional chemotherapeutics would further increase coverage by 13.9%. Conclusion This study is the first, to our knowledge, to assess worldwide variation in practical access to pediatric chemotherapy. Although mapping the proportion of available chemotherapeutics is informative, we also developed a meaningful estimate of access using disease-specific drug packages. These data provide an important baseline for continued monitoring and can aid in planning adaptive treatment guidelines that consider the trade-offs between access and outcomes.
Automating Treatment Summary Development Using Electronic Billing Information: A Pilot Study of Survivors of Head and Neck Cancer
Authors: Baxi Shrujal S. , Sukhu Ranjit , Fortier Elizabeth , Oeffinger Kevin , Corcoran Stacie , Salner Andrew , Vickers Andrew J. , McCabe Mary S. , Salz Talya 
Published: December 2018

PURPOSE: Although the provision of a treatment summary (TS) is a quality indicator in oncology, routine delivery of TSs remains challenging. Automatic TS generation could facilitate use, but data on accuracy are lacking in complex cancers such as head and neck cancer (HNC). We developed and evaluated an electronic platform to automate TS generation for HNC. METHODS: The algorithms autopopulated TSs using data from billing records and an institutional cancer registry. A nurse practitioner used the medical record to verify the accuracy of the information and made corrections electronically. Inaccurate and missing data were considered errors. We described and investigated reasons for errors in the automatically generated TSs. RESULTS: We enrolled a heterogeneous population of 43 survivors of HNC. Using billing data, the information on primary site, lymph node status, radiation, and chemotherapy use was accurate in 93%, 95%, 93%, and 95% of patients, respectively. Billing data captured surgery accurately in 77% of patients; once an omitted billing code was identified, accuracy increased to 98%. Chemotherapies were captured in 90% of patients. Using the cancer registry, month and year of diagnosis were accurate in 91% of cases; stage was accurate in 28% of cases. Reprogramming the algorithm to ascertain clinical stage when pathologic stage was unavailable resulted in 100% accuracy. The algorithms inconsistently identified radiation receipt and treating physicians from billing data. CONCLUSION: It is feasible to automatically and accurately generate most components of TSs for HNC using billing and cancer registry data, although clinical review is necessary in some cases.
End-of-life Considerations and Shared Decision Making in Neurocritical Care
Authors: Lazaridis Christos 
Published: December 2018

ABSTRACTThe goal of shared decision making in the neurocritical care setting is to form plans of care that are consistent with best medical practice and are respectful of the patient’s values. Close cooperation and meaningful interaction must be achieved with family members so that the patient’s “person can emerge” through discussions. This article highlights several caveats that can subvert this complex process, including the cognitive biases that affect both clinicians and surrogates. Impact, optimism, and gain-framing biases may be particularly relevant when considering patients who are receiving neurocritical care. Practitioners need to be cognizant of the distorting influences of these biases and make attempts to neutralize them. Quality of survival and the nature and degree of deficits are often the dominant concerns after patients experience acute severe brain injuries. Care should be taken to avoid conflating medical facts and value judgments when discussing prognoses.
Relationship between Candida albicans and Streptococcus mutans in early childhood caries, evaluated by quantitative PCR
Authors: Bachtiar Endang W. , Bachtiar Boy M. 
Published: December 2018

Background:The aim of this study was to analyze the synergistic relationship betweenCandida albicansandStreptococcus mutansin children with early childhood caries (ECC) experience.Methods:Dental plaque and unstimulated saliva samples were taken from 30 subjects aged 3-5 years old, half with (n=15, dmft > 4) and half without (n=15) ECC. The abundance ofC. albicansandS. mutansand relative to total bacteria load were quantify by real-time PCR (qPCR). This method was also employed to investigate the mRNA expression of glycosyltransferase (gtfB) gene in dental plaque. Student’s t-test and Pearson’s correlation were used to perform statistical analysis.Results:Within the ECC group, the quantity of both microorganisms were higher in the saliva than in dental plaque. The ratio ofC. albicansto total bacteria was higher in saliva than in plaque samples (p < 0.05). We observed the opposite forS. mutans(p < 0.05). The different value ofC. albicansandS. mutansin saliva was positively correlated, and negatively correlated in dental plaque. Transcription level ofS. mutans gtfBshowed a positive correlation withC. albicansconcentration in dental plaque. Conclusion:C. albicanshas a positive correlation with cariogenic traits ofS. mutansin ECC-related biofilm of young children.
Effects of maternal stress during pregnancy and up to two years after birth on risk of child overweight and obesity: Protocol for a Systematic Review
Authors: Cooney Jennifer , Flannery Caragh , Khashan Ali S. , Huizink Anja C. , Matvienko-Sikar Karen 
Published: December 2018

Background: Childhood obesity presents a significant public health challenge globally. The period from conception to two years after birth, the first 1000 days, represents a critical period during which the experience of maternal stress may be related to the development of childhood obesity. Research to date suggests some positive associations between maternal stress during the first 1000 days and childhood obesity, but findings are inconsistent and have not yet been comprehensively synthesised. The purpose of this review is to systematically examine the association between maternal stress during the first 1000 days and the risk of child overweight and obesity. Methods: The following electronic databases will be searched from inception using a detailed search strategy: the Cochrane Library, MEDLINE, PsycINFO, EMBASE, CINAHL, Maternity and Infant Care, and Web of Science. Cohort, case-control, and cross-sectional studies examining maternal stress during the first 1000 days and child overweight and obesity up to the age of 12 years will be included. Titles, abstracts and full articles will be screened by two investigators independently to identify eligible studies. A standardised data extraction form will be used to extract data including: study design; maternal stress exposure; child outcome; exclusion criteria; participant characteristics; and assessment methods. The Cochrane Collaboration’s bias classification tool for observational studies will be used to assess study quality. This protocol is reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses protocol (PRISMA-P) checklist, and the systematic review will be conducted and reported following the PRISMA checklist. If possible, random effects models will be used to perform meta-analyses. Ethics and dissemination: Ethical approval is not required for this study as it will not involve conducting experimental research, nor include identifying personal data. The systematic review will be disseminated in peer-reviewed journals. PROSPERO registration number: CRD42018100363
Asthma phenotypes and their impact on treatment
Authors: Gawlik-Lipinski Aleksandra 
Published: December 2018

Patients with asthma can have varying characteristics, and therefore they need different treatments. Knowing asthma phenotypes can aid practice nurses to better understand how to best manage their patients' condition, as Aleksandra Gawlik-Lipinski describes Asthma is characterised by the presence of a wheeze, a cough, breathlessness, tightness in the chest and various levels of airway obstruction ( Chapman et al, 2014 , British Thoracic Society and Scottish Intercollegiate Guidelines Network, 2016 ). There is diversity among asthma patients and it was in the final decade of twentieth century that asthma was categorised into phenotypes ( Wenzel, 2012a ). A phenotype is an observable manifestation of the interaction between an individual's genotype and their environment ( Marieb and Hoehn, 2012 ). Traditionally, phenotypes are based on clinical, molecular and individual characteristics, designed to recognise different treatment requirements among asthma patients and deliver targeted therapy ( Chung et al, 2014 ). Apart from inhaled corticosteroids, eosinophilic, early- and late-onset asthma phenotypes benefit from leukotriene receptor antagonists (LTRAs) and monoclonal anti-immunoglobin E therapy; obesity-related, non-eosinophilic phenotype from weight management; and allergic bronchopulmonary mycoses from antifungal treatment ( Haldar et al, 2008 ; Moore et al, 2010 ; Wenzel, 2012b ). The treatments of early-onset, non-eosinophilic phenotype with LTRAs ( Bacci et al, 2006 ; Paggiaro and Bacci, 2011 ) and the neutrophilic phenotype solely with macrolide antibiotics ( Wenzel, 2012b ) continue to be debated.
Kandungan Pigmen, Total Fenolik Dan Aktivitas Antioksidan Sargassum sp.
Authors: Sedjati Sri , Supriyantini Endang , Ridlo Ali , Soenardjo Nirwani , Santi Victorina Yulina 
Published: December 2018

Pigmen content, total phenolic compound and antioxidant activity Sargassum sp. Sargassum sp. contains secondary metabolites which potentially act as natural source of antioxidant. The purpose of this study was to determine bioactive contents (pigments, total phenolic compounds), and antioxidant activities of Sargassum sp. The method of this research is descriptive-explorative. Sample was extracted with methanol, while pigments extraction with aseton 80%. Chlorophyll a, b and carotenoids were carried out with spectrophotometer method. The total phenolic compounds were analyzed by spectrophotometer method using Follin-Ciocalteu reagent, and antioxidant activities were measured using DPPH (1,1-diphenyl-2- picrylhidrazyl) method. The result of this research showed that methanol extract of Sargassum sp. had the presence of chlorophyll a 2.84 mg/g, chlorophyll b 1.15 mg/g, and carotenoids 2.63 μmol/g sample. The total phenolic compounds of methanol extract were 57.97 mg GAE/g sample. Methanol extract of Sargassum sp. was showing a strong antioxidant activity that could be seen in IC50 value (69,27 ppm) in less than 100 ppm concentration. Sargassum sp. mengandung beberapa metabolit sekunder yang berpotensi sebagai sumber antioksidan alami. Tujuan dari penelitian ini adalah mengkaji komponen bioaktif (pigmen, total fenolik) dan aktivitas antioksidan dari rumput laut Sargassum sp. Metoda penelitian ini adalah diskriptif eksploratif. Sampel Sargassum sp. basah diekstraksi dengan cara maserasi dengan pelarut metanol, sedangkan ekstraksi pigmen menggunakan aseton 80%. Penentuan kadar pigmen (klorofil a, b, karotenoid ), total fenolik dan aktivitas antioksidan berdasarkan metode spektrofotometri. Total fenolik diukur berdasarkan uji Follin-Ciocalteu, dan aktivitas antioksidan berdasarkan uji DPPH (1,1-diphenyl-2- picrylhidrazyl). Hasil penelitian menunjukan bahwa ekstrak metanol Sargassum sp. mengandung pigmen klorofil a sebesar 2,84 mg/g, klorofil b sebesar 1,15 mg/g, dan karotenoid sebesar 2,63 μmol/g. Kadar total fenolik ekstrak metanol adalah 57,97 mgGAE/g, sementara aktivitas antioksidannya (IC50) sebesar 69,27 ppm. Berdasarkan nilai IC50nya, ekstrak metanol Sargassum sp berpotensi sebagai antioksidan kuat (kurang dari 100 ppm).
TANGGUNGJAWAB OTORITAS JASA KEUANGAN TERHADAP PENGELOLAAN DANA PENSIUN SYARIAH DI UNIVERSITAS MUHAMMADIYAH SURAKARTA
Authors: Yunita Ani , Setyaningrum Reni Budi , Annas Muhammad 
Published: December 2018

Penelitian ini bertujuan untuk mengetahui pelaksanaan dan hambatan pengelolaan dana pensiun di Lembaga Dana Pensiun Universitas Muhammadiyah Surakarta serta tanggungjawab Otoritas Jasa Keuangan Solo dalam menjalankan wewenang pengawasan terhadap pengelolaan dana pensiun di Lembaga Dana Pensiun Universitas Muhammadiyah Surakarta. Metode penelitian hukum yang digunakan untuk mencapai tujuan penelitian hukum ialah yuridis empiris dengan menggunakan sumber data primer dan data sekunder. Hasil penelitian diketahui pengelolaan dana pensiun di UMS telah berjalan sesuai dengan peraturan namun, ada beberapa hambatan yaitu Pendiri dan Dewan Pengawas Syariah masih belum mendapatkan Surat Pengangkatan dari Dewan Syariah Nasional dan Majelis Ulama Indonesia. Pengawasan Otoritas Jasa Keuangan Solo terhadap pengelolaan dana pensiun syariah masih belum optimal. OJK dalam menegakkan syariah compliance bagi pelaku bisnis syariah di Lembaga Keuangan Syariah harus taat hukum.
Design and Characterization of Periodically Conductive Woven Fabric
Authors: Guan Fuwang , Li Zhaole , Yang Zhuli , Zhang Chuyang , Qiu Yiping 
Published: December 2018

Abstract
In this paper, a novel kind of electromagnetic (EM) functional textiles is proposed, which show high-pass characteristics as they interact with EM waves. The periodically conductive woven fabric was designed, fabricated, and measured. Specifically, by means of unit cell model building and EM simulation, the theoretical S21 (transmission coefficient) and S11 (reflection coefficient) curves were obtained. A concrete sample was fabricated through weaving process, and its transmission characteristics were measured in the microwave anechoic chamber. The measured and simulated results were highly consistent, demonstrating the validity of design process. Compared with the aluminum foil paper sample, the S21 values of fabricated sample were a little smaller, and the reason could be attributed to yarn crimp and surface roughness. The EM characteristics of fabricated sample under two different polarization modes were slightly different, which was due to the beating-up tension of weaving process. The work could offer new research ideas, and the related products have potential advantages over rigid plates on the account of textile characteristics.