bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is metal hyperaccumulation occurring in ultramafic vegetation of central and southern Mexico?
Authors: Navarrete Gutiérrez Dulce Montserrat , Pons Marie‐Noëlle , Cuevas Sánchez Jesús Axayacatl , Echevarria Guillaume 
Published: February 2018

AbstractIn Mexico, ultramafic complexes are present in different regions from the northwest (Baja California Norte) to the southeast (Chiapas). In this paper, we present the results of the exploration of three ultramafic (serpentine) habitats in central and southern Mexico: Cuicatlán–Concepción Pápalo (Oaxaca), Tehuitzingo–Tecomatlán (Puebla), and San Juan de Otates (Guanajuato). Previous geology studies showed that these complexes are mainly made up of serpentinized peridotites. Soil analyses demonstrated typical ultramafic characteristics such as high content of Mg in relation to Ca, and high concentrations of Fe, Cr, Co, and Ni. Soil samples from Oaxaca and Puebla had similar Ni contents around 2300 mg kg−1, while samples of Guanajuato showed the lowest Ni levels with an average of 200 mg kg−1 as well as for other metals such as Co, Cr, Mn, and Zn. During this study, 83 plant specimens were collected, of which 52 were identified at genus level and 40 at species level. The collected plants belong to 19 different families such as Anacardiaceae, Fabaceae, Acanthaceae, Asteraceae, Sterculiaceae, and Verbenaceae which are also widely present in other ultramafic areas in Iran, Brazil, Sri Lanka, and Costa Rica. Only two Mexican endemic species are included in the collection. Ni hyperaccumulators were not detected at any of the studied sites. Therefore, hyperaccumulation, as a tolerance mechanism of the flora in response to ultramafic geochemical stress, does not seem to be developed in Central Mexico, as observed in the close Costa Rican site of Santa Elena.
Impact of the International Nosocomial Infection Control Consortium (INICC)’s Multidimensional Approach on Rates of Central Line-Associated Bloodstream Infection in 14 Intensive Care Units in 11 Hospitals of 5 Cities in Argentina
Authors: Rosenthal Victor Daniel , Desse Javier , Maurizi Diego Marcelo , Chaparro Gustavo Jorge , Orellano Pablo Wenceslao , Chediack Viviana , Cabrera Rafael , Golschmid Daniel , Silva Cristina Graciela , Vimercati Julio Cesar , Stagnaro Juan Pablo , Perez Ivanna , Spadaro María Laura , Montanini Adriana Miriam , Pedersen Dina , Paniccia Teresa Laura , Aguilera Ana María Ríos , Cermesoni Raul , Mele Juan Ignacio , Alda Ernesto , Paldoro Analía Edith , Ortta Agustín Román , Cooke Bettina , García María Cecilia , Obed Mora Nair , Domínguez Cecilia Verónica , Saúl Pablo Alejandro , Rodríguez del Valle María Cecilia , Bianchi Alberto Claudio , Alvarez Gustavo , Pérez Ricardo , Oyola Carolina 
Published: February 2018

OBJECTIVETo analyze the impact of the International Nosocomial Infection Control Consortium (INICC) Multidimensional Approach (IMA) and the INICC Surveillance Online System (ISOS) on central line-associated bloodstream infection (CLABSI) rates in 14 intensive care units (ICUs) in Argentina from January 2014 to April 2017.DESIGNThis prospective, pre–post surveillance study of 3,940 ICU patients was conducted in 11 hospitals in 5 cities in Argentina. During our baseline evaluation, we performed outcome and process surveillance of CLABSI applying Centers for Disease Control and Prevention/National Health Safety Network (CDC/NHSN) definitions. During the intervention, we implemented the IMA through ISOS: (1) a bundle of infection prevention practice interventions, (2) education, (3) outcome surveillance, (4) process surveillance, (5) feedback on CLABSI rates and consequences, and (6) performance feedback of process surveillance. Bivariate and multivariate regression analyses were performed using a logistic regression model to estimate the effect of the intervention on the CLABSI rate.RESULTSDuring the baseline period, 5,118 CL days and 49 CLABSIs were recorded, for a rate of 9.6 CLABSIs per 1,000 central-line (CL) days. During the intervention, 15,659 CL days and 68 CLABSIs were recorded, for a rate of 4.1 CLABSIs per 1,000 CL days. The CLABSI rate was reduced by 57% (incidence density rate: 0.43; 95% confidence interval, 0.34–0.6; P<.001).CONCLUSIONSImplementing IMA through ISOS was associated with a significant reduction in the CLABSI rate in ICUs in Argentina.Infect Control Hosp Epidemiol 2018;39:445–451
Educating in Respect: Against Neutral Discourse as a Norm for Respectful Classroom Discussion
Authors: Easton Christina 
Published: February 2018

AbstractSince 2014, British schools have been required to ‘actively promote’ the value of ‘mutual respect’ to the children in their care. This is relatively unproblematic: liberals are agreed that good citizenship education will involve teaching mutual respect. However, there is disagreement over how ‘respect’ should be understood and what it should imply for norms of respectful classroom discussion. Some political liberals have indicated that when engaging in discussion in the classroom, students should provide only neutral reasons to defend their views. This paper provides a number of arguments against this claim. For example, I argue that this norm relies on a distorted understanding of what it is to respect others and that it stifles the development of civic and epistemic virtue in the next generation of citizens. Even from within the perspective of political liberalism, there are good reasons to favour critical discussion of non-neutral reasons. Education policy should therefore accord greater priority to discussion of students’ actual motivating reasons than to discussion constrained by a norm of neutral discourse.
Toward an understanding of the eschatological presence of the risen Jesus with Robert Jenson
Authors: Lee Sang Hoon 
Published: February 2018

AbstractThis article will attempt to demonstrate the plausibility of Robert Jenson's account of the Son's existence before his earthly lifetime by arguing that the retroactive presence of the risen Jesus is what Jenson means, and by reflecting on the relationship between the way that grace and power of Christ reaches to the people of Israel and the concept of retrocausality in physics. This article restricts its discussion to the presence of the risen Jesus in the economy, leaving aside the question of the eternity–time relation, on the grounds that one may constructively engage with Jenson's account, regardless of his or her view of eternity.
EFFECTS OF INTERPERSONAL TRUST AMONG USERS OF ONLINE HEALTH COMMUNITIES ON PATIENT TRUST IN AND SATISFACTION WITH THEIR PHYSICIAN
Authors: Audrain-Pontevia Anne-Françoise , Menvielle Loick 
Published: February 2018

Objectives:Online Health Communities (OHCs) are increasingly being used by patients in the Web 2.0 era. Today's patients have instant access to a great deal of medical information and contacts. Despite the considerable development of OHCs, little is known regarding the impact on the patient–physician relationship. This research aims at filling this gap and examines how interpersonal trust on peer-to-peer OHCs influences two key relational variables, namely patient trust in the physician and patient satisfaction with the physician. It also investigates their influences on the patient's attitude toward the physician.Methods:Drawing on both the relational and medical literatures, we propose a research model that brings out the relationships between interpersonal trust in OHCs, and patients’ trust, satisfaction and attitude toward the physician. We then conduct a quantitative survey of 512 OHC users in France, using structural equation modeling to test our hypotheses.Results:Our findings indicate that interpersonal trust in OHCs exerts a positive influence on both patients’ trust in and satisfaction with their physician. It also highlights that these two relational variables have a positive influence on patient attitude toward the physician. Our findings also indicate that patient trust influences patient satisfaction with the physician.Conclusions:This research highlights the importance of OHCs, which can be seen as valuable instruments for enhancing patient–physician relationships. It shows that healthcare managers should seek to enhance interpersonal trust among OHC users, because this trust has a positive influence on patient satisfaction with, trust in and attitude toward the physician.
2-aminopurine suppresses the TGF-β1-induced epithelial–mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis
Authors: Weng Dong , Chen Jian-xia , Li Hao-hao , Liu Feng , Zhou Li-dan , Liu Hai-peng , Zheng Rui-juan , Jiang Yan , Liu Zhong-hua , Ge Baoxue 
Published: February 2018

AbstractThe epithelial–mesenchymal transition (EMT) is a multifunctional cell process involved in the pathogenesis of numerous conditions, including fibrosis and cancer. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease characterized by fibroblast accumulation and collagen deposition in the lungs. The fibroblasts involved in this process partially originate from lung epithelial cells via the EMT. Evidence suggests that the EMT contributes to progression, invasion, and metastasis of various types of cancer. We screened a series of 80 compounds for the ability to interfere with the EMT and potentially be applied as a therapeutic for IPF and/or lung cancer. We identified 2-aminopurine (2-AP), a fluorescent analog of guanosine and adenosine, as a candidate in this screen. Herein, we demonstrate that 2-AP can restore E-cadherin expression and inhibit fibronectin and vimentin expression in TGF-β1–treated A549 lung cancer cells. Moreover, 2-AP can inhibit TGF-β1-induced metastasis of A549 cells. This compound significantly attenuated bleomycin (BLM)-induced pulmonary inflammation, the EMT, and fibrosis. In addition, 2-AP treatment significantly decreased mortality in a mouse model of pulmonary fibrosis. Collectively, we determined that 2-AP could inhibit metastasis in vitro by suppressing the TGF-β1-induced EMT and could attenuate BLM-induced pulmonary fibrosis in vivo. Results of this study suggest that 2-AP may have utility as a treatment for lung cancer and pulmonary fibrosis.
Insight into induced charges at metal surfaces and biointerfaces using a polarizable Lennard–Jones potential
Authors: Geada Isidro Lorenzo , Ramezani-Dakhel Hadi , Jamil Tariq , Sulpizi Marialore , Heinz Hendrik 
Published: February 2018

AbstractMetallic nanostructures have become popular for applications in therapeutics, catalysts, imaging, and gene delivery. Molecular dynamics simulations are gaining influence to predict nanostructure assembly and performance; however, instantaneous polarization effects due to induced charges in the free electron gas are not routinely included. Here we present a simple, compatible, and accurate polarizable potential for gold that consists of a Lennard–Jones potential and a harmonically coupled core-shell charge pair for every metal atom. The model reproduces the classical image potential of adsorbed ions as well as surface, bulk, and aqueous interfacial properties in excellent agreement with experiment. Induced charges affect the adsorption of ions onto gold surfaces in the gas phase at a strength similar to chemical bonds while ions and charged peptides in solution are influenced at a strength similar to intermolecular bonds. The proposed model can be applied to complex gold interfaces, electrode processes, and extended to other metals.
Split spawning realigns coral reproduction with optimal environmental windows
Authors: Foster Taryn , Heyward Andrew J. , Gilmour James P. 
Published: February 2018

AbstractSplit spawning in coral populations occurs when gamete maturation and mass spawning are split over two consecutive months. While split spawning has been observed at many reefs, little is known about the frequency and significance of these events. Here we show that split spawning occurred frequently and predictably over a decade at Scott Reef. Split spawning overlays the biannual spawning pattern in the region and occurs when the full moon falls in the first week of the usual spawning month, or the last week of the previous month. Additionally, in split years most species have their main spawning event after a 13-month lunar cycle, in the month following the usual spawning month. Without split spawning, spawn dates would shift by ~10 days each year to occur outside of optimal environmental windows. Our results suggest that split spawning is driven by a disconnect between lunar and seasonal cues, and is analogous with a ‘leap year’ in coral reproduction, realigning spawning dates with favourable conditions for reproduction.
Involvement of impaired autophagy and mitophagy in Neuro-2a cell damage under hypoxic and/or high-glucose conditions
Authors: Song Yufei , Du Yu , Zou Wenying , Luo Yan , Zhang Xiaojie , Fu Jianliang 
Published: February 2018

AbstractChronic cerebral hypoperfusion (CCH) plays an insidious role in the development of cognitive impairment. Considerable evidence suggests that Diabetes Mellitus (DM) as a vascular risk factor may exacerbate CCH and is closely related to cognitive decline. Dysregulation of autophagy is known to be associated with the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease. To elucidate the role of autophagy in CCH- and/or DM-related pathogenesis, mouse neuroblastoma Neuro-2a cells were exposed to hypoxia and/or high glucose for 48 h, mimicking CCH complicated with DM pathologies. Chronic hypoxia reduced cell proliferation and increased levels of cleaved caspase-3, whereas high glucose had no obvious synergistic toxic effect. Accumulation of autophagic vacuoles under hypoxia may be due to both autophagy impairment and induction, with the former accounting for Neuro-2a cell death. Additionally, aberrant accumulation of mitochondria in Neuro-2a cells may be attributed to insufficient BNIP3-mediated mitophagy due to poor interaction between BNIP3 and LC3-II. Despite the lack of a significant cytotoxic effect of high glucose under our experimental conditions, our data indicated for the first time that impaired autophagy degradation and inefficient BNIP3-mediated mitophagy may constitute mechanisms underlying neuronal cell damage during chronic hypoxia.
Null Model and Community Structure in Multiplex Networks
Authors: Zhai Xuemeng , Zhou Wanlei , Fei Gaolei , Liu Weiyi , Xu Zhoujun , Jiao Chengbo , Lu Cai , Hu Guangmin 
Published: February 2018

AbstractThe multiple relationships among objects in complex systems can be described well by multiplex networks, which contain rich information of the connections between objects. The null model of networks, which can be used to quantify the specific nature of a network, is a powerful tool for analysing the structural characteristics of complex systems. However, the null model for multiplex networks remains largely unexplored. In this paper, we propose a null model for multiplex networks based on the node redundancy degree, which is a natural measure for describing the multiple relationships in multiplex networks. Based on this model, we define the modularity of multiplex networks to study the community structures in multiplex networks and demonstrate our theory in practice through community detection in four real-world networks. The results show that our model can reveal the community structures in multiplex networks and indicate that our null model is a useful approach for providing new insights into the specific nature of multiplex networks, which are difficult to quantify.
Very long-/ and long Chain-3-Hydroxy Acyl CoA Dehydrogenase Deficiency correlates with deregulation of the mitochondrial fusion/fission machinery
Authors: Hagenbuchner Judith , Scholl-Buergi Sabine , Karall Daniela , Ausserlechner Michael J. 
Published: February 2018

AbstractChildren diagnosed with Long-Chain-3-Hydroxy-Acyl-CoA-Dehydrogenase-Deficiency (LCHADD) or Very-Long-Chain-3-Hydroxy-Acyl-CoA-Dehydrogenase-Deficiency (VLCADD) frequently present with hypertrophic cardiomyopathy or muscle weakness which is caused by the accumulation of fatty acid metabolites due to inactivating mutations in the mitochondrial trifunctional protein. By analyzing mitochondrial morphology we uncovered that mutations within the HADHA or the ACADVL gene not only affect fatty acid oxidation, but also cause significant changes in the DNM1L/MFN2 ratio leading to the significant accumulation of truncated and punctate mitochondria in contrast to network-like mitochondrial morphology in controls. These striking morphological abnormalities correlate with changes in OXPHOS, an imbalance in ROS levels, reduced mitochondrial respiration, reduced growth rates and significantly increased glucose uptake per cell, suggesting that HADHA and ACADVL mutations shift cellular energy household into glycolysis. Experiments using the NOX2-specific inhibitor Phox-I2 suggest that NOX2 is activated by accumulating long-chain fatty acids and generates ROS, which in turn changes mitochondrial morphology and activity. We thereby provide novel insights into the cellular energy household of cells from LCHADD/VLCADD patients and demonstrate for the first time a connection between fatty acid metabolism, mitochondrial morphology and ROS in patients with these rare genetic disorders.
Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats
Authors: Tong W. W. , Zhang C. , Hong T. , Liu D. H. , Wang C. , Li J. , He X. K. , Xu W. D. 
Published: February 2018

AbstractSilibinin, a natural polyphenolic flavonoid, possesses anti-oxidant, anti-inflammation and anti-cancer properties. The present study was designed to investigate the effects of silibinin on rheumatoid arthritis (RA) pathogenesis-related cells and collagen-induced arthritis (CIA) and further explore the potential underlying mechanisms. Our results showed that silibinin suppressed cell viability and increased the percentage of apoptotic RA-fibroblast-like synoviocytes (FLS). Furthermore, the production of inflammatory cytokines in RA-FLS and a CIA rat model was effectively inhibited by silibinin. Silibinin also induced macrophage M2 polarization in RAW264.7 cells. We further demonstrated that silibinin inhibits Th17 cell differentiation in vitro. The nuclear factor kappa B (NF-κB) pathway was suppressed in RA-FLS. In addition, Sirtuin1 (SIRT1) was decreased after silibinin treatment, and RA-FLS transfection with a short hairpin RNA (shRNA) of SIRT1 enhanced silibinin-induced apoptosis. Autophagy was markedly decreased in a dose-dependent manner following silibinin treatment. These findings indicate that silibinin inhibited inflammation by inhibiting the NF-κB pathway, and SIRT1 may participate in silibinin-induced apoptosis. Silibinin also inhibited autophagy in RA-FLS. Thus, silibinin may be a potential therapeutic agent for the treatment of RA.
Simultaneous acquisition of EEG and NIRS during cognitive tasks for an open access dataset
Authors: Shin Jaeyoung , von Lühmann Alexander , Kim Do-Won , Mehnert Jan , Hwang Han-Jeong , Müller Klaus-Robert 
Published: February 2018

AbstractWe provide an open access multimodal brain-imaging dataset of simultaneous electroencephalography (EEG) and near-infrared spectroscopy (NIRS) recordings. Twenty-six healthy participants performed three cognitive tasks: 1) n-back (0-, 2- and 3-back), 2) discrimination/selection response task (DSR) and 3) word generation (WG) tasks. The data provided includes: 1) measured data, 2) demographic data, and 3) basic analysis results. For n-back (dataset A) and DSR tasks (dataset B), event-related potential (ERP) analysis was performed, and spatiotemporal characteristics and classification results for ‘target’ versus ‘non-target’ (dataset A) and symbol ‘O’ versus symbol ‘X’ (dataset B) are provided. Time-frequency analysis was performed to show the EEG spectral power to differentiate the task-relevant activations. Spatiotemporal characteristics of hemodynamic responses are also shown. For the WG task (dataset C), the EEG spectral power and spatiotemporal characteristics of hemodynamic responses are analyzed, and the potential merit of hybrid EEG-NIRS BCIs was validated with respect to classification accuracy. We expect that the dataset provided will facilitate performance evaluation and comparison of many neuroimaging analysis techniques.
Device performance analysis for lead‐free perovskite solar cell optimisation
Authors: Bishnoi Sonu , Pandey Saurabh Kumar 
Published: February 2018

A comprehensive numerical analysis for a lead‐free perovskite solar cell (PSC) has been carried out using device simulation software. Various factors affecting the solar cell's performance have been investigated for device optimisation; more specifically optimisation of device buffer and the absorber layer. Different design strategies for optimising the power conversion efficiency (PCE) through solar cell capacitance simulator numerical simulation have been proposed. Enumerated study of the effects of thickness, band gap, light illumination and defect area on the PCE is carried out. In this study, two types of configurations (La0.7 Sr0.3 MnO3 /zinc oxide and La0.7 Sr0.3 MnO3 /Nb:SrTiO3) are simulated which gives highest conversion efficiency of 11% at 600 nm and 32% at 350 nm wavelength. The impact of defect density has also been addressed to analyse the performance of cell module. The optimisation of device parameters pinpoints enormous potential for the enhancement of conversion efficiency of high‐efficient PSC.
Climate for women in climate science: Women scientists and the Intergovernmental Panel on Climate Change
Authors: Gay-Antaki Miriam , Liverman Diana 
Published: February 2018

Significance
Women in science face barriers to professional advancement. One of the most important forums for international climate science is the Intergovernmental Panel on Climate Change, where there has been a slow increase in the proportion of women authors since the first assessment in 1990. Our survey of more than 100 female Intergovernmental Panel on Climate Change authors explores their experience and perceptions, the barriers to their full participation that they identify, and recommendations for improvements. While we find that some women reported a positive experience, others felt women were poorly represented and heard and encountered barriers beyond their gender including race, nationality, command of English, and discipline. The study contributes to the larger literature on gender and science and provides recommendations for greater inclusion.
Digital signaling network drives the assembly of the AIM2-ASC inflammasome
Authors: Matyszewski Mariusz , Morrone Seamus R. , Sohn Jungsan 
Published: February 2018

Significance
The complexity of biological signaling pathways parallels the design of modern electronic circuits. The AIM2-ASC inflammasome is a filamentous signaling platform that plays an essential role in defense against foreign dsDNA arising from invading pathogens. Currently, the design principles of the AIM2-ASC “signaling circuit” remain poorly understood. Here, we found that the assembly of the AIM2-ASC inflammasome filters short dsDNA as noise at each signaling step. dsDNA induces hysteresis, and the assembly generates multistage, virtually infinite signal amplification. Moreover, an array of positive feedback loops reinforces the assembly. Together with a quantitative model of the assembly pathway, we demonstrate that an ultrasensitive digital circuit drives the assembly of the AIM2-ASC inflammasome on foreign dsDNA.