bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unconventional T Cells in the Pancreatic Tumor Microenvironment: Thinking Outside the Box
Authors: Banerjee Sulagna , Dudeja Vikas , Saluja Ashok 
Published: September 2019

Abstract

Summary:
Unlike conventional MHC-reactive T cells, unconventional T cells have emerged as an abundant component of the human immune system because of their role in tumor immunology. In this issue of Cancer Discovery, Hundeyin and colleagues have identified a population of unconventional T cells in pancreatic tumors that can reprogram the immune evasive components of the tumor to promote immunogenicity and thus are critical for the development of novel cell-based therapy in pancreatic cancer.
See related article by Hundeyin et al., p. 1288.
Individual Alpha Frequency Predicts Perceived Visuotactile Simultaneity
Authors: Migliorati Daniele , Zappasodi Filippo , Perrucci Mauro Gianni , Donno Brunella , Northoff Georg , Romei Vincenzo , Costantini Marcello 
Published: September 2019

Abstract
Temporal encoding is a key feature in multisensory processing that leads to the integration versus segregation of perceived events over time. Whether or not two events presented at different offsets are perceived as simultaneous varies widely across the general population. Such tolerance to temporal delays is known as the temporal binding window (TBW). It has been recently suggested that individual oscillatory alpha frequency (IAF) peak may represent the electrophysiological correlate of TBW, with IAF also showing a wide variability in the general population (8–12 Hz). In our work, we directly tested this hypothesis by measuring each individual's TBW during a visuotactile simultaneity judgment task while concurrently recording their electrophysiological activity. We found that the individual's TBW significantly correlated with their left parietal IAF, such that faster IAF accounted for narrower TBW. Furthermore, we found that higher prestimulus alpha power measured over the same left parietal regions accounted for more veridical responses of non-simultaneity, which may be explained either by accuracy in perceptual simultaneity or, alternatively, in line with recent proposals by a shift in response bias from more conservative (high alpha power) to more liberal (low alpha power). We propose that the length of an alpha cycle constrains the temporal resolution within which perceptual processes take place.
Acceptance of Full Driving Automation: Personally Owned and Shared-Use Concepts
Authors: Motamedi Sanaz , Wang Pei , Zhang Tingting , Chan Ching-Yao 
Published: August 2019

Objective This study aims to develop user acceptance models for two concepts of full driving automation: personally owned and shared use. Background Many manufacturers have been investing considerably in and actively developing full driving automation. However, factors influencing user acceptance of full driving automation are not yet fully understood. Method This study consisted of two parts: focus group discussions and online surveys. A total of 30 potential users participated in focus groups to discuss their perception of full driving automation acceptance. Based on the findings from focus group discussions, theoretical foundations, and empirical evidence, we hypothesized the acceptance models for both personally owned and shared-use concepts. We tested the models with 310 and 250 participants, respectively, online. Results The results of focus groups indicated that users’ concerns are centered around safety, usefulness, compatibility, trust, and ease of use. The survey results revealed the important roles of perceived usefulness and perceived safety in both models, whereas the direct impact of perceived ease of use was found to be insignificant. The indirect impact of perceived ease of use was less significant in the personally owned than in the shared-use model, whereas usefulness, trust, and compatibility played more important roles in the personally owned when compared with the shared-use model. Conclusion The findings uncovered a chain of constructs that affect behavioral intention to use for both full driving automation concepts. Application The framework and outcome of this study provide valuable guidelines that allow better understanding for government agencies, manufacturers, and automation designers regarding users’ acceptance of full driving automation.
Baseline surgical status and short-term mortality after extracorporeal membrane oxygenation for post-cardiotomy shock: a meta-analysis
Authors: Kowalewski Mariusz , Raffa Giuseppe , Zieliński Kamil , Meani Paolo , Alanazi Musab , Gilbers Martijn , Heuts Samuel , Natour Ehsan , Bidar Elham , Schreurs Rick , Delnoij Thijs , Driessen Rob , Sels Jan Willem , van de Poll Marcel , Roekaerts Paul , Maessen Jos , Suwalski Piotr , Lorusso Roberto 
Published: August 2019

Objective: While reported mortality rates on post-cardiotomy extracorporeal membrane oxygenation vary from center to center, impact of baseline surgical status (elective/urgent/emergency/salvage) on mortality is still unknown. Methods: A systematic search was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement using PubMed/Medline databases until March 2018 using the keywords “postcardiotomy,” “cardiogenic shock,” “extracorporeal membrane oxygenation,” and “extracorporeal life support.” Relevant articles were scrutinized and included in the meta-analysis only if reporting in-hospital/30-day mortality and baseline surgical status. The correlations between mortality and percentage of elective/urgent/emergency cases were investigated. Inference analysis of baseline status and extracorporeal membrane oxygenation complications was conducted as well. Results: Twenty-two studies (conducted between 1993 and 2017) enrolling N = 2,235 post-cardiotomy extracorporeal membrane oxygenation patients were found. Patients were mostly of non-emergency status (65.2%). Overall in-hospital/30-day mortality event rate (95% confidence intervals) was 66.7% (63.3-69.9%). There were no differences in in-hospital/30-day mortality with respect to baseline surgical status in the subgroup analysis (test for subgroup differences; p = 0.406). Similarly, no differences between mortality in studies enrolling <50 versus ⩾50% of emergency/salvage cases was found: respective event rates were 66.9% (63.1-70.4%) versus 64.4% (57.3-70.8%); p = 0.525. Yet, there was a significant positive association between increasing percentage of emergency/salvage cases and rates of neurological complications (p < 0.001), limb complications (p < 0.001), and bleeding (p = 0.051). Incidence of brain death (p = 0.099) and sepsis (p = 0.134) was increased as well. Conclusion: Other factors than baseline surgical status may, to a higher degree, influence the mortality in patients treated with extracorporeal membrane oxygenation for post-cardiotomy cardiogenic shock. Baseline status, however, strongly influences the complication occurrence while on extracorporeal membrane oxygenation.
A Majority of Anterior Cruciate Ligament Injuries Can Be Prevented by Injury Prevention Programs: A Systematic Review of Randomized Controlled Trials and Cluster–Randomized Controlled Trials With Meta-analysis
Authors: Huang Yu-Lun , Jung Jaehun , Mulligan Colin M.S. , Oh Jaekeun , Norcross Marc F. 
Published: August 2019

Background: Anterior cruciate ligament (ACL) injury prevention programs (IPPs) are generally accepted as being valuable for reducing injury risk. However, significant methodological limitations of previous meta-analyses raise questions about the efficacy of these programs and the extent to which meeting current best-practice ACL IPP recommendations influences the protective effect of these programs. Purpose: To (1) estimate the protective effect of ACL IPPs while controlling for common methodological limitations of previous meta-analyses and (2) systematically categorize IPP components and factors related to IPP delivery to assess the validity of current best-practice IPP recommendations. Study Design: Systematic review with meta-analysis. Methods: A systematic search of 5 electronic scientific databases was conducted to identify studies testing the efficacy of ACL IPPs. Studies were included if (1) the intervention aimed to prevent ACL injury, (2) the incidence rate (IR) or other outcome data that made it possible to calculate the IR for both the intervention and control groups were reported, and (3) the study design was a prospective randomized controlled trial (RCT) or cluster-RCT. Results: Of the 2219 studies screened, 8 studies were included in the quantitative synthesis, and their analysis revealed a significant reduction in ACL IR when athletes received IPPs (IR ratio = 0.47; 95% CI, 0.30-0.73; P < .001). The majority of included IPPs tended to meet minimum best-practice recommendations and incorporated plyometric, strengthening, and agility exercises along with feedback on proper landing technique. However, the specific exercises included in each IPP and key factors related to IPP delivery were highly variable. Conclusion: Despite limiting the analysis to only high-quality studies and controlling for time at risk and potential clustering effects, the study showed that ACL IPPs had a significant protective effect and reduced injury rates by 53%. However, significant variability in the specific exercises and the manner of program delivery suggests that ACL IPPs may be able to be designed within an overarching best-practice framework. This may allow practitioners the flexibility to develop IPPs that meet the specific characteristics of the target population and potentially increase the likelihood that these programs will be widely adopted and implemented.
Globalization and Its Effects on Musicians and Folk Culture
Authors: Balonek Michael T. 
Published: September 2019

Globalization, the meeting of ideas and goods from culture to culture around the world, has a direct effect on many aspects of life internationally. In this article, I look at both positive as well as negative effects of globalization on the lives of musicians, as well as in the use of folk arts. This includes: 1. the decline of some traditional South Asian folk arts and a change in their function due to the arrival of Western medicine; 2. the increase in students playing particular kinds of instruments; 3. changes in how students learn music with the arrival of Western-style schools; and 4. foreign technological advances changing how music students assess their own performances and goals.. This globalization sometimes leaves people who flourished as performers are now living in poverty, while it also creates opportunities for others who never previously had a chance to learn certain instruments. I also briefly touch upon the sometimes hidden sociological and psychological effects that globalization can bring, such as reducing some culturally accepted venues for ladies to share their pain and suffering with others. I conclude with some suggestions based on the above topics, and the plea for researchers and musicians to not pretend like globalization will not affect life within South Asia, but instead to work with it to find positive outcomes.
Medication persistence rates and predictive factors for discontinuation of antifibrotic agents in patients with idiopathic pulmonary fibrosis: a real-world observational study
Authors: Oishi Keiji , Hirano Tsunahiko , Murata Yoriyuki , Hamada Kazuki , Uehara Sho , Suetake Ryo , Yamaji Yoshikazu , Asami-Noyama Maki , Edakuni Nobutaka , Ohata Syuichiro , Utsunomiya Toshiaki , Sakamoto Kenji , Onoda Hideko , Matsumoto Tsuneo , Matsunaga Kazuto , Yano Masafumi 
Published: September 2019

Background: In patients with idiopathic pulmonary fibrosis (IPF), continuing treatment with antifibrotic agents is crucial to decrease the reduction of forced vital capacity and mortality rate. However, predictive factors for the discontinuation of antifibrotic agents are unknown. This study aims to investigate the clinical characteristics and predictive factors for the discontinuation of antifibrotic agents in patients with IPF. Methods: This was a double-center retrospective study that enrolled patients with IPF treated with pirfenidone or nintedanib between 2009 and 2017. We compared clinical parameters between the medication-continuing group and the discontinued group. The predictive factors were determined using Cox proportional hazards analyses. Results: A total of 66 subjects were included: 43 received pirfenidone and 23 received nintedanib. At 1 year, 23 of 66 patients had discontinued due to adverse events ( n = 12), disease progression ( n = 9), or death ( n = 2). The characteristics of the discontinuation group were poor performance status (PS) and delay from diagnosis to treatment. In the receiver operating characteristic (ROC) analysis associated with the discontinuation of antifibrotic agents, PS was the highest area under the ROC curve (AUC) value (cut-off value, 2; AUC, 0.83; specificity, 63%; sensitivity, 87%). This finding was consistent even when analyzing, except for examples of death and adjusting for the type of antifibrotic agent. The treatment persistence rate by PS was PS 0–1 = 90%, PS 2 = 65%, and PS 3 = 19%. Analysis of the relationship between PS and administration period of antifibrotic agents revealed that delays from diagnosis to treatment led to worsening of dyspnea, a decline in lung function, and deterioration of PS. Conclusions: PS may be informative for predicting discontinuation of medication. Our data reinforced the importance of early initiation of antifibrotic treatment, and we suggest PS should be used as a guide for starting antifibrotic agents in everyday practice. The reviews of this paper are available via the supplementary material section.
Metabolic syndrome is a risk factor for colorectal adenoma and cancer: a study in a White population using the harmonized criteria
Authors: Milano Angelo , Bianco Maria Antonia , Buri Luigi , Cipolletta Livio , Grossi Enzo , Rotondano Gianluca , Tessari Francesco , Efthymakis Konstantinos , Neri Matteo 
Published: September 2019

Background: Metabolic syndrome (MetS) has been associated with colorectal adenomas and cancer. However, MetS definitions have changed over time, leading to a heterogeneity of patients included in previous studies and a substantial inextensibility of observations across time or eastern and western populations. Our aim was to evaluate the association of ‘harmonized’ criteria-defined MetS and its individual components with colorectal neoplasia and cancer in a western population. Methods: In this multicenter, cross-sectional study, we prospectively evaluated consecutive outpatients who underwent open-access colonoscopy over a 3-month period. MetS was diagnosed according to the 2009 ‘harmonized’ criteria. Results: Out of 5707 patients enrolled, we found 213 cancers (3.7%), 1614 polyps (28.3%), 240 nonpolypoid lesions (4.2%), 95 laterally spreading tumors (1.6%). Polyps presented histological low-grade dysplasia in 72.9% of samples, while in 9.8%, high-grade dysplasia or in situ carcinoma was present; dysplasia rates for nonpolypoid lesions were 66.2% (low-grade) and 2.9% (high-grade/ in situ carcinoma), while for laterally spreading tumors, 29.6% and 37%, respectively. Overall, MetS prevalence was 41.6%. MetS correlated with both adenomas [odds ratio (OR): 1.76, 95% confidence interval (CI) 1.54–2.00] and cancer (OR: 1.92, 95% CI 1.42–2.58). MetS was the only risk factor for such colonic lesions in subjects younger than 50 years. For all colonic neoplasia, we found MetS and not its individual components to be significantly associated. Conclusions: MetS is risk factor for cancer and adenoma in Whites, especially when younger than 50 years. MetS patients might be considered as a high-risk population also in colorectal cancer screening programs.
Predictors of Radiographic Osteoarthritis 2 to 3 Years After Anterior Cruciate Ligament Reconstruction: Data From the MOON On-site Nested Cohort
Authors:   MOON Knee Group, Jones Morgan H. , Oak Sameer R. , Andrish Jack T. , Brophy Robert H. , Cox Charles L. , Dunn Warren R. , Flanigan David C. , Fleming Braden C. , Huston Laura J. , Kaeding Christopher C. , Kolosky Michael , Kuyumcu Gokhan , Lynch T. Sean , Magnussen Robert A. , Matava Matthew J. , Parker Richard D. , Reinke Emily K. , Scaramuzza Erica A. , Smith Matthew V. , Winalski Carl , Wright Rick W. , Zajichek Alexander , Spindler Kurt P. 
Published: August 2019

Background: Multiple studies have shown that patients are susceptible to posttraumatic osteoarthritis (PTOA) after an anterior cruciate ligament (ACL) injury, even with ACL reconstruction (ACLR). Prospective studies using multivariable analysis to identify risk factors for PTOA are lacking. Purpose/Hypothesis: This study aimed to identify baseline predictors of radiographic PTOA after ACLR at an early time point. We hypothesized that meniscal injuries and cartilage lesions would be associated with worse radiographic PTOA using the Osteoarthritis Research Society International (OARSI) atlas criteria. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 421 patients who underwent ACLR returned on-site for standardized posteroanterior semiflexed knee radiography at a minimum of 2 years after surgery. The mean age was 19.8 years, with 51.3% female patients. At baseline, data on demographics, graft type, meniscal status/treatment, and cartilage status were collected. OARSI atlas criteria were used to grade all knee radiographs. Multivariable ordinal regression models identified baseline predictors of radiographic OARSI grades at follow-up. Results: Older age (odds ratio [OR], 1.06) and higher body mass index (OR, 1.05) were statistically significantly associated with a higher OARSI grade in the medial compartment. Patients who underwent meniscal repair and partial meniscectomy had statistically significantly higher OARSI grades in the medial compartment (meniscal repair OR, 1.92; meniscectomy OR, 2.11) and in the lateral compartment (meniscal repair OR, 1.96; meniscectomy OR, 2.97). Graft type, cartilage lesions, sex, and Marx activity rating scale score had no significant association with the OARSI grade. Conclusion: Older patients with a higher body mass index who have an ACL tear with a concurrent meniscal tear requiring partial meniscectomy or meniscal repair should be advised of their increased risk of developing radiographic PTOA. Alternatively, patients with an ACL tear with an articular cartilage lesion can be reassured that they are not at an increased risk of developing early radiographic knee PTOA at 2 to 3 years after ACLR.
Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome
Authors: Ma Lisa , Herren Anthony W. , Espinal Glenda , Randol Jamie , McLaughlin Bridget , Martinez-Cerdeño Veronica , Pessah Isaac N. , Hagerman Randi J. , Hagerman Paul J. 
Published: September 2019

AbstractFragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder associated with a premutation repeat expansion (55–200 CGG repeats) in the 5′ noncoding region of the FMR1 gene. Solitary intranuclear inclusions within FXTAS neurons and astrocytes constitute a hallmark of the disorder, yet our understanding of how and why these bodies form is limited. Here, we have discovered that FXTAS inclusions emit a distinct autofluorescence spectrum, which forms the basis of a novel, unbiased method for isolating FXTAS inclusions by preparative fluorescence-activated cell sorting (FACS). Using a combination of autofluorescence-based FACS and liquid chromatography/tandem mass spectrometry (LC-MS/MS)-based proteomics, we have identified more than two hundred proteins that are enriched within the inclusions relative to FXTAS whole nuclei. Whereas no single protein species dominates inclusion composition, highly enriched levels of conjugated small ubiquitin-related modifier 2 (SUMO 2) protein and p62/sequestosome-1 (p62/SQSTM1) protein were found within the inclusions. Many additional proteins involved with RNA binding, protein turnover, and DNA damage repair were enriched within inclusions relative to total nuclear protein. The current analysis has also allowed the first direct detection, through peptide sequencing, of endogenous FMRpolyG peptide, the product of repeat-associated non-ATG (RAN) translation of the FMR1 mRNA. However, this peptide was found only at extremely low levels and not within whole FXTAS nuclear preparations, raising the question whether endogenous RAN products exist at quantities sufficient to contribute to FXTAS pathogenesis. The abundance of the inclusion-associated ubiquitin- and SUMO-based modifiers supports a model for inclusion formation as the result of increased protein loads and elevated oxidative stress leading to maladaptive autophagy. These results highlight the need to further investigate FXTAS pathogenesis in the context of endogenous systems.
Frequency-dependent S-wave splitting parameters analysis: A case study from azimuthal PS data, Sanhu area of the Qaidam Basin, China
Authors: Wang Yun , Wang Chao , Li Jianfeng , Yue Yuanyuan 
Published: August 2019

The Sanhu area, which is located in the eastern Qaidam Basin in China and formed of low-amplitude anticlinal and lithologic traps, is a favorable area for biogas exploration. The fracture systems in this area are characterized in detail with the use of frequency-dependent S-wave splitting parameters, which are sensitive to the size of the fractures. The results indicate that the delay time between slow and fast S-waves decreases rapidly with increasing frequency between 5 and 30 Hz, and then it slowly decreases to a stationary value at high frequencies. Moreover, the frequency-dependent delay times suggest that fractures of different scale have different 2D density distribution. The frequency-dependent orientation of the fractures suggests that large-scale fractures, which correspond to a low-frequency band (5–11 Hz), are oriented at approximately N48°E and have small random disturbances. The mesoscale fractures that correspond to the dominant frequency band (12–36 Hz) are oriented along approximately N54°E in the northeastern region and N45°E over the remaining area. As expected, the average fracture orientation and delay time of the dominant frequency band are consistent with previous results from conventional S-wave splitting analysis in the time domain, but the frequency-dependent fracture orientation and delay time indicate finer heterogeneity and spatial anomalies. In summary, the results show the potential for accurately characterizing fracture systems using frequency-dependent S-wave splitting parameters.