Alterações bioquímicas em ratos com doença periodontal e tratados com olmesartana, captopril e atorvastatina
Authors: Souza Graziene Lopes de , Araújo Aurigena Antunes , Silva Gisele Ribeiro da , Silva Larissa Marina Pereira , Lima Flávio Maurílio dos Santos , Mata Neida Da 
Published: April 2018

<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:HyphenationZone>21</w:HyphenationZone> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>PT-BR</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--> <p class="MsoNormal" style="text-align: justify; line-height: 150%;"><span style="line-height: 15px;">Introdução: A doença periodontal é o processo inflamatório que ocorre na gengiva em resposta a antígenos bacterianos da placa </span><span style="line-height: 15px;">dentária. Como a doença periodontal acomete indivíduos adultos, principalmente, idosos, a presença desta patologia em pacientes </span><span style="line-height: 15px;">com fatores de risco para doenças cardiovasculares, que estão fazendo utilização de medicamentos se torna um achado usual. </span><span style="line-height: 15px;">Objetivo: verificar as alterações bioquímicas decorrentes da utilização subcrônica de Olmesartana, Captopril e Atovastatina em </span><span style="line-height: 15px;">animais com doença periodontal. Metodologia: Foram utilizados 50 ratos Wistar com pesos entre 250-400g, a doença periodontal </span><span style="line-height: 15px;">foi induzida com ligadura de fio nylon 3-0, por 10 dias, os animais receberam dose oral única e diária de Olmesartana (1 e 10mg/</span><span style="line-height: 15px;">Kg), Captopril (1,5 e 10mg/Kg) e Atovastatina (1,5 e 10mg/Kg). No 11º dia cada subgrupo foi eutanasiado com Tiopental sódico </span><span style="line-height: 15px;">na dosagem de 20 mg/Kg e o sangue colhido para avaliação bioquímica. As variáveis estudadas foram glicose, creatinina, uréia, </span><span style="line-height: 15px;">colesterol total, triglicerídeos, HDL, LDL, TGO e TGP A leitura foi realizada no equipamento semiiautomático BioPlus 2000®. Para </span><span style="line-height: 15px;">verificar as diferenças entre os grupos estudados foi utilizado o Teste t de Student com nível de significância de 5% no programa </span><span style="line-height: 15px;">Graf Pad Install. Resultados: A doença periodontal elevou significantemente os níveis de glicose, LDL-C e colesterol total (p<0,05). </span><span style="line-height: 15px;">Além disso nos animais tratados com atovastatin, um efeito farmacológico esperado, que era redução nos níveis de LDL-C, e </span><span style="line-height: 15px;">aumento do HDL-C, não foram encontrados. Conclusão: O estudo aponta para um importante efeito da doença periodontal, na </span><span style="line-height: 15px;">resposta a medicamentos sistêmicos.</span></p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="9" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 3" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 4" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 5" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 6" /> <w:LsdException Locked="false" 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