bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transition management in individual organizational career planning
Authors: Laser Jan 
Published: May 2019

Purpose
The purpose of this paper is to introduce the subjective perspective via the transition approach to organizational career planning so that employees’ individual transition phases can be evaluated, planned and guided.

Design/methodology/approach
A theoretical–conceptual analysis is conducted in this paper.

Findings
The individual perspective can be included in career planning via the transition approach. By dividing the transition into individual phases, the different requirements of employees over the course of time can be analysed individually and corresponding measures (for example coaching) can be derived.

Originality/value
The added value of this paper is that organizational career planning can individually analyse employees’ transitions, using a transition approach, increasing the likelihood of a successful transition.
The Use of Roche, Wainer, and Thissen's Skeletal Maturity of the Knee
Authors: Konigsberg Lyle W. , Sgheiza Valerie 
Published: May 2019

AbstractThe Roche, Wainer, and Thissen (RWT) knee method was designed to assess maturity in living individuals, but is infrequently cited in studies of skeletal measures for legal age thresholds or estimation of age‐at‐death for forensic cases. We implement the RWT method using R scripts and analyze its utility in establishing an age threshold of 18 years. We fit the RWT model and verify its accuracy in estimating skeletal age against results and known age data provided by RWT. We also found the transition distribution for full skeletal maturity. Agreement between the RWT method and our implementation was good, with a maximum deviation of 0.03 years. The modes of transition to full skeletal maturity are 18.37 and 17.16 years for males and females. The corresponding Bayes factors are 5.73 and 1.77, indicating that complete skeletal maturity of the knee does not provide conclusive evidence of attainment of 18 years of age.
Fluorescence of a Natural Fluorophore as a Key to Improve Fingerprint Contrast Image
Authors: Oliveira Ana Celeste Ximenes , Leão Alexandre , Balzuweit Karla , Siman Livia , Mesquita Oscar Nassif , Ladeira Luiz Orlando , Cury Luiz Alberto 
Published: May 2019

AbstractThe optical and morphological properties of resveratrol were investigated. This nontoxic fluorescent natural material, emitting in the visible blue light, was used as an optical marker, enabling the enhancement of the image contrast coming from relief pictures marked on challenging surfaces. By applying appropriated imaging softwares, this marker was verified to be very useful in the latent fingerprint recognition deposited on different wood surface types, mainly those with high level of roughness, where conventional forensic materials do not allow effective fingerprint image visualization.
Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris
Authors: Liao Sha , Han Liwen , Zheng Xiaopu , Wang Xin , Zhang Peng , Wu Jingni , Liu Ruimin , Fu Youlan , Sun Jiaxin , Kang Ximeng , Liu Kechun , Fan Tai‐ping , Li Shao , Zheng Xiaohui 
Published: May 2019

Background and PurposeTanshinol borneol ester (DBZ) is a novel synthetic compound derived from Dantonic®, a botanical drug approved in 26 countries outside the United States for angina pectoris and currently undergoing FDA Phase III clinical trial. Here, we investigated the angiogenic effects of (S)‐DBZ and (R)‐DBZ isomers in vitro and in vivo.Experimental ApproachA network pharmacology approach was used to predict molecular targets of DBZ. The effects of DBZ isomers on proliferation, migration, and tube formation of human endothelial cells were assessed. For in vivo approaches, the transgenic Tg (vegfr2:GFP) zebrafish and C57BL/6 mouse Matrigel plug models were used. ELISA and western blots were used to quantitate the release and expression of relevant target molecules and signalling pathways.Key ResultsDBZ produced a biphasic modulation on proliferation and migration of three types of human endothelial cells. Both DBZ isomers induced tube formation in Matrigel assay and a 12‐day co‐culture model in vitro. Moreover, DBZ promoted Matrigel neovascularization in mice and partially reversed the vascular disruption in zebrafish induced by PTK787. Mechanistically, DBZ enhanced the cellular levels of VEGF, VEGFR2, and MMP‐9, as well as activating Akt and MAPK signalling in endothelial cells. Selective inhibition of PI3K and MEK significantly attenuated its angiogenic effects.Conclusions and ImplicationsThese data reveal, for the first time, that DBZ promotes multiple key steps of angiogenesis, at least in part through Akt and MAPK signalling pathways, and suggest it may be potentially developed further for treating myocardial infarction and other cardiovascular diseases.
Interactions among threats affect conservation management outcomes: Livestock grazing removes the benefits of fire management for small mammals in Australian tropical savannas
Authors: Legge Sarah , Smith James G. , James Alex , Tuft Katherine D. , Webb Terry , Woinarski John C. Z. 
Published: May 2019

AbstractConservation scientists and practitioners usually focus on understanding and managing individual threats to biodiversity. However, threats may interact, making management outcomes unpredictable. Here, we investigated whether interactions between fire regimes and introduced livestock affect the conservation goal of population recovery for small mammals in Australia's tropical savannas, using a long‐term and landscape‐scale study. Mammal richness and abundance increased as management reduced the average annual fire extent and frequency at large and medium scales. However, these relationships between fire and richness and abundance were only evident in areas where introduced livestock were removed. This interaction may arise because predation by feral cats is amplified in areas with reduced vegetation ground cover, and cover is reduced over longer periods when livestock have access to burnt areas, because they selectively graze regenerating grass. Fire management for conservation receives substantial investment across northern Australia, and in savannas worldwide; this study shows that without appropriate management of other factors, this investment may be ineffective. More broadly, managing single threats to biodiversity may be compromised if interactions between threats are not explicitly considered. This study provides an example of how such interactions can be evaluated for improved biodiversity conservation.
In ST‐segment elevation myocardial infarction, the echocardiographic parameters of microvascular obstruction are not associated with left ventricular remodeling at five years of follow‐up
Authors: Dregoesc Mihaela Ioana , Iancu Adrian Corneliu , Ober Camelia Diana , Homorodean Cãlin , Bãlãnescu Şerban , Bolboacã Sorana 
Published: May 2019

ObjectiveThe correlation between the echocardiographic Doppler flow parameters of microvascular obstruction (MVO) and coronary wedge pressure (CWP) measured as a marker of severe compressive microvascular dysfunction and a predictor of adverse left ventricular remodeling was evaluated in a group of high‐risk acute anterior myocardial infarction survivors.MethodsTwenty‐four patients with mechanically reperfused anterior STEMI were divided into two groups based on the 38 mm Hg CWP cutoff for adverse left ventricular remodeling. Diastolic deceleration time (DDT), coronary flow reserve (CFR), systolic retrograde flow, peak systolic and peak diastolic velocities in the infarct‐related artery were determined 3–5 days after revascularization. An echocardiographic 20% increase in left ventricular volumes defined adverse remodeling.ResultsNo significant differences were recorded between groups with regard to the echocardiographic parameters of MVO. No significant correlation was identified between CWP on one side and DDT (P = 0.30) and CFR (P = 0.39) on the other, irrespective of total ischemic time and extracted thrombus length. No difference in 5 years of follow‐up left ventricular remodeling was detected in patients with DDT<900 msec as compared to those with DDT≥900 msec. The medium increase in left ventricular end‐systolic volume in patients with low CWP was 24.78%, while it reached 127.27% (P = 0.03) in patients with CWP>38 mm Hg.ConclusionsCoronary wedge pressure did not correlate with the surrogate parameters for MVO, but it was a predictor of left ventricular remodeling. None of the echocardiographic MVO parameters was associated with adverse remodeling at 5 years of follow‐up.
Investigating the association between callous‐unemotional traits with relational bullying and victimization: A cross‐national study
Authors: Fanti Kostas A. , Kokkinos Costantinos M. , Voulgaridou Ioanna , Hadjicharalambous Maria‐Zoe 
Published: May 2019

AbstractPrior research supports an association between callous‐unemotional (CU) traits with relational bullying, but evidence associating CU traits with relational victimization is limited. Further, the relationship between CU traits with relational “bully,” “bully‐victim,” and “victim” classifications has been largely neglected. The current study addresses these critical gaps in the literature using a cross‐national study design. The sample comprised of 1887 (51.5% of girls) Greek and Cypriot children (MAge = 11.17) who completed a battery of self‐report measures. Group differences suggested that children in the relational bully and bully‐victim groups scored higher on CU traits compared to children in the victim and low‐risk groups. Although these associations were similar across countries, boys in Greece were more likely to be identified in the bullying only group. In contrast, boys in Cyprus represented the higher percentage identified as bully‐victims and girls in Cyprus represented the higher percentage identified as victim‐only. Regression analysis results indicated that CU traits predicted relational bullying but not victimization. Notwithstanding, other important unexamined factors known to contribute to relational bullying and victimization, our findings suggest that prevention efforts should consider CU traits in order to protect youth from relational bullying. However, differences between countries and gender should also be taken into account.
Effects of fibrinogen supplementation on clot formation in blood samples from cardiac surgery patients before and after tranexamic acid administration
Authors: Waldén K. , Shams Hakimi C. , Jeppsson A. , Karlsson M. 
Published: May 2019

SummaryObjectivesTo investigate if supplementation with fibrinogen concentrate to blood samples collected after tranexamic acid administration improve clot formation more than what can be achieved with fibrinogen in the absence of tranexamic acid.BackgroundIt is not known if the combination of fibrinogen and tranexamic acid has additional effects than what can be achieved individually.MethodsFour blood samples were collected from 15 coronary artery bypass patients. Two samples were collected before surgery, before and after 2 g tranexamic acid was administered. The preoperative samples were diluted to haematocrit 21%. Two samples were collected after surgery, before and after a second dose of 2 g tranexamic acid. Fibrinogen concentrate corresponding to a dose of 3 g in a 70‐kg patient was added to the samples. Platelet‐independent clotting time and maximum clot firmness assessed by thromboelastometry (ROTEM‐FIBTEM®) were compared between the samples.ResultsAdministration of tranexamic acid shortened clotting time marginally (−6%) before surgery, P = 0·029) but did not influence clot firmness. Fibrinogen concentrate shortened clotting time (−14% before and −12% after surgery, both P = 0·003) and increased clot firmness (+51 and +39%, both P < 0·001). The effects of fibrinogen did not differ before and after tranexamic acid administration. Fibrinolysis was not detected in any sample.ConclusionsThe results of this in vitro study suggest that the enhancing effects of fibrinogen on clot firmness in blood samples from cardiac surgery patients are not further increased in the presence of tranexamic acid. Further studies on patients with ongoing bleeding and/or hyperfibrinolysis are necessary to validate the results.
Integrating water‐saving schemes in the design of sanitary sewers
Authors: Basupi Innocent 
Published: May 2019

AbstractUrbanisation and climate change worsen the ever‐increasing gap between demand and the supply of water. Closing the gap between water demand and supply remains a global challenge that influences the growing uptake of water‐saving schemes (WSSs) to reduce the threat to water security. This study proposes a method for simultaneous design of sanitary sewers (SSs) and the selection of WSSs. An integrated design approach (or problem) that matches SSs with WSSs was formulated and solved as a multi‐objective optimisation problem. The two objectives considered are: (1) minimisation of the total cost and (2) maximisation of the cost benefits of interventions. The main constraints considered include the sanitary sewer technical and hydraulic performances. The problem was solved using the well‐known NSGA2 optimisation technique. The proposed method was demonstrated using a subsystem of the Tsholofelo Extension sanitary sewer in Gaborone. The results obtained from the integrated approach suggest that WSSs influence designs of the sanitary sewer (SS) and the other way round.
Imipramine as an alternative to formamide to detubulate rat ventricular cardiomyocytes
Authors: Bourcier Aurelia , Barthe Marion , Bedioune Ibrahim , Lechêne Patrick , Miled Hela Ben , Vandecasteele Grégoire , Fischmeister Rodolphe , Leroy Jérôme 
Published: May 2019

New Findings
What is the central question of this study?
Can imipramine, an antidepressant agent that is a cationic amphiphilic drug that interferes with the phosphatidylinositol 4,5‐bisphosphate (PI(4,5)P2) interactions with proteins maintaining the tubular system, be validated as a new detubulating tool?

What is the main finding and its importance?
Imipramine was validated as a more efficient and less toxic detubulating agent of cardiomyocytes than formamide. New insights are provided on how PI(4,5)P2 is crucial to maintaining T‐tubule attachment to the cell surface and on the cardiotoxic effects of imipramine overdoses.

AbstractCardiac T‐tubules are membrane invaginations essential for excitation–contraction coupling (ECC). Imipramine, like other cationic amphiphilic drugs, interferes with phosphatidylinositol 4,5‐bisphosphate (PI(4,5)P2) interactions with proteins maintaining the tubular system connected to the cell surface. Our main purpose was to validate imipramine as a new detubulating agent in cardiomyocytes. Staining adult rat ventricular myocytes (ARVMs) with di‐4‐ANEPPS, we showed that unlike formamide, imipramine induces a complete detubulation with no impact on cell viability. Using the patch‐clamp technique, we observed a ∼40% decrease in cell capacitance after imipramine pretreatment and a reduction of ICa,L amplitude by ∼72%. These parameters were not affected in atrial cells, excluding direct side effects of imipramine. β‐Adrenergic receptor (β‐AR) stimulation of the remaining ICa,L with isoproterenol (Iso) was still effective. ECC was investigated in ARVMs loaded with Fura‐2 and paced at 1 Hz, allowing simultaneous measurement of the Ca2+ transient (CaT) and sarcomere shortening (SS). Amplitude of both CaT and SS was decreased by imipramine and partially restored by Iso. Furthermore, detubulated cells exhibited Ca2+ homeostasis perturbations. Real‐time cAMP variations induced by Iso using a Förster resonance energy transfer biosensor revealed ∼27% decreased cAMP elevation upon β‐AR stimulation. To conclude, we validated a new cardiomyocyte detubulation method using imipramine, which is more efficient and less toxic than formamide. This antidepressant agent induces the hallmark effects of detubulation on ECC and its β‐AR stimulation. Besides, we provide new insights on how an imipramine overdose may affect cardiac function and suggest that PI(4,5)P2 is crucial for maintaining T‐tubule structure.
Dynamic Analysis of Hydro-Turbine Governing System with Multistochastic Factors
Authors: Li Jianling , Chen Diyi , Zhang Hao , Liu Jing 
Published: May 2019

Abstract
This paper explores the stability of a hydro-turbine governing system (HTGS) under simultaneous effects of multistochastic factors. Specifically, three different sets of stochastic factors are introduced into the governing system, and the corresponding mathematical model with multistochastic factors is proposed. Then, seven cases are performed to reveal the dynamic characteristics of the governing system, including the excitations of only single stochastic factor, two stochastic factors, and three stochastic factors with different combinations of stochastic parameters. The results show some interesting phenomena. First, the stability of the system is weakened by introducing stochastic variables ω2 and ω3 into the inlet pressure of hydro-turbine (h2) and the bottom pressure of the surge tank (h3) separately, or both. Second, the negative effects of the stochastic characteristics of h2 and h3 on the governing system are reduced by introducing the stochastic variable (ω1) into the hydro-turbine flow (q1), on the basis of fully considering the influence of the stochastic characteristics of h2 and h3. Third, stochastic factors are generally considered to be unfavorable, but it may help the system to reach a global optimum status under certain conditions, which break through the habit of empirical thinking. Finally, this work not only provides a new insight for stochastic phenomena existing in engineering system, but also lays a theoretical basis for the safe and stable operation of the hydropower stations.
Associations between common ECG abnormalities and out-of-hospital cardiac arrest
Authors: Søndergaard Marc Meller , Nielsen Jonas Bille , Mortensen Rikke Nørmark , Gislason Gunnar , Køber Lars , Lippert Freddy , Graff Claus , Haunsø Stig , Svendsen Jesper Hastrup , Kragholm Kristian Hay , Pietersen Adrian Holger , Lind Bent Struer , Hjortshøj Søren Pihlkjær , Holst Anders Gaarsdal , Struijk Johannes Jan , Torp-Pedersen Christian , Hansen Steen Møller 
Published: May 2019

BackgroundOut-of-hospital cardiac arrest (OHCA) is often the first manifestation of unrecognised cardiac disease. ECG abnormalities encountered in primary care settings may be warning signs of OHCA.ObjectiveWe examined the association between common ECG abnormalities and OHCA in a primary care setting.MethodsWe cross-linked individuals who had an ECG recording between 2001 and 2011 in a primary care setting with the Danish Cardiac Arrest Registry and identified OHCAs of presumed cardiac cause.ResultsA total of 326 227 individuals were included and 2667 (0,8%) suffered an OHCA. In Cox regression analyses, adjusted for age and sex, the following ECG findings were strongly associated with OHCA: ST-depression without concomitant atrial fibrillation (HR 2.79; 95% CI 2.45 to 3.18), left bundle branch block (LBBB; HR 3.44; 95% CI 2.85 to 4.14) and non-specific intraventricular block (NSIB; HR 3.15; 95% CI 2.58 to 3.83). Also associated with OHCA were atrial fibrillation (HR 1.89; 95% CI 1.63 to 2.18), Q-wave (HR 1.75; 95% CI 1.57 to 1.95), Cornell and Sokolow-Lyon criteria for left ventricular hypertrophy (HR 1.56; 95% CI 1.33 to 1.82 and HR 1.27; 95% CI 1.12 to 1.45, respectively), ST-elevation (HR 1.40; 95% CI 1.09 to 1.54) and right bundle branch block (HR 1.29; 95% CI 1.09 to 1.54). The association between ST-depression and OHCA diminished with concomitant atrial fibrillation (HR 1.79; 95% CI 1.42 to 2.24, p < 0.01 for interaction). Among patients suffering from OHCA, without a known cardiac disease at the time of the cardiac arrest, 14.2 % had LBBB, NSIB or ST-depression.ConclusionsSeveral common ECG findings obtained from a primary care setting are associated with OHCA.
The effect of fumigation on nematode communities in California almond orchards
Authors: Hodson Amanda K. , Milkereit Janina , John Gavin C. , Doll David A. , Duncan Roger A. 
Published: May 2019

Summary
Fumigants, such as 1,3-dichloropropene and chloropicrin, have become key to pre-plant pest management in almond production. Whilst the use of these fumigants has become increasingly restricted due to human health concerns, less is known about their below-ground non-target effects in orchards and how nematode communities recover from fumigation over time. In this study, replicated trials compared 1,3-dichloropropene + chloropicrin to non-treated controls in two almond orchards in California, USA. Nematode communities, nematode indices and nematode metabolic footprints were quantified soon after fumigation and for 2 years afterwards. Fumigation reduced the Herbivore Metabolic Footprint in year 1, and populations of Pratylenchus vulnus in year 3. Fumigation also reduced populations of larger omnivores and predators, resulting in lower levels of the Structure Index at one site. Populations of fungal-feeding nematodes were more adversely affected by fumigation than bacterial-feeding nematode populations. At both sites, fumigation still influenced nematode community composition 2 years after treatment application.
Multicenter research on tumor and pregnancy outcomes in patients with early-stage cervical cancer after fertility-sparing surgery
Authors: Wang Aihong , Cui Guanyi , Jin Canhui , Wang Ying , Tian Xiaoyu 
Published: May 2019

Objective To investigate tumor and pregnancy outcomes after fertility-sparing surgery for cervical cancer. Methods A total of 83 patients with cervical cancer who received fertility-sparing surgery at 10 gynecologic cancer research centers in Henan Province were enrolled from January 2010 to June 2016. Clinical data and follow-up results were collected. Of them, 78 had cervical squamous carcinoma and five had cervical adenocarcinoma. International Federation of Gynecology and Obstetrics (2009) staging showed that 26 patients had stage IA1, 11 had stage IA2, and 46 had stage IBI. Seventy-two patients underwent radical trachelectomy and retroperitoneal lymphadenectomy, whereas 11 underwent subradical trachelectomy and retroperitoneal lymphadenectomy. Moreover, 17 patients received one to two courses of preoperative neoadjuvant chemotherapy and five received two to four courses of postoperative chemotherapy. Eighty-three patients were followed up postoperatively (median follow-up duration, 36.2 months). Results With regard to tumor outcomes, one (1.2%) patient showed recurrence following fertility-sparing surgery. In 69 patients with planned pregnancy after treatment, 54 had 58 pregnancies, including 42 full-term births and eight premature births. Seventy-nine patients were satisfied with their quality of life. Conclusions Radical/subradical trachelectomy is safe and effective as fertility-sparing surgery for young patients with early cervical cancer, with good pregnancy outcomes.