bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute effects of air pollutants on adverse birth outcomes in Changsha, China
Authors: Xiong Lili , Xu Zenghui , Tan Jie , Wang Hua , Liu Zhiyu , Wang Aihua , Xie Donghua , Kong Fanjuan 
Published: January 2019

Abstract
Evidence for the acute effects of air pollutants on adverse birth outcomes is not yet conclusive. Furthermore, there are no investigations relating to the association between air pollutants and macrosomia. The aim of this study was to determine the relationship between air pollutants and low birth weight, preterm birth, and macrosomia in Changsha. Time-series analysis, using a generalized additive model was applied. Data about the adverse birth outcomes was collected from 78 midwifery institutions. Air pollution data including SO2, NO2, particulate matter <10 μm in diameter (PM10), particulate matter <2.5 μm in diameter (PM2.5), O3, CO, and climate data were respectively collected from the Changsha Environmental Protection Agency and the Changsha Meteorological Bureau from January 2015 to December 2017. During the study period, there were 344,880 live births to be studied. In a single pollutant model, for every increase of 10 μg/m3 in PM10 and PM2.5, low birth weight increased by 0.12% (95% confidence interval [CI]: 0.01–0.23%) at a lag 06 and 0.44% (95% CI: 0.35–0.53%) at a lag 3, respectively. Preterm birth increased most by 1.60% (95% CI: 1.41–1.80%) at a lag 2 for every increase of 10 μg/m3 in SO2. The highest increases in macrosomia associated with a 10 μg/m3 increase in air pollutant were 3.53% (95% CI: 3.41–3.64%) for NO2 at lag 0, 3.33% (95% CI: 3.05–3.60%) for SO2 at lag03. Multi-pollutant models showed that only PM10 increased the low birth weight and preterm birth risk effect by 3.91% (95% CI: 3.67–4.12%) and 0.25% (95% CI: 0.14–0.37%). NO2 increased macrosomia risk by 4.14% (95% CI: 3.97–4.31%) with a 10 μg/m3 increase. There was no association observed between the air pollutants O3 and CO and adverse birth outcomes. Pregnant women should also take steps to limit their exposure to high levels of air pollutants during the final weeks of pregnancy.
Herbal medicine for acute management and rehabilitation of traumatic brain injury
Authors: Lee Boram , Leem Jungtae , Kim Hyunho , Jo Hee-Geun , Yoon Sang-Hoon , Shin Aesook , Sul Jae-Uk , Choi Ye-Yong , Yun Younghee , Kwon Chan-Young 
Published: January 2019

Abstract

Background:
This systematic review protocol describes the methods that will be used to evaluate the efficacy and safety of herbal medicine in treating traumatic brain injury.

Methods and analysis:
The following electronic databases will be searched up to December 2018 without language or publication status restrictions: Medline, EMBASE, the Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database, and Cumulative Index to Nursing and Allied Health Literature. We will also search Korean, Chinese, and Japanese databases. Any randomized controlled trials related to herbal medicine for traumatic brain injury will be included. The functional outcome, consciousness state, morbidity, and mortality will be assessed as primary outcomes. The quality of life, adverse events, and total effective rate will be evaluated as secondary outcomes. Two researchers will independently perform the study selection, data extraction, assessment of study quality, and evaluation of the quality of evidence for the main findings. Data synthesis and analysis will be performed using RevMan version 5.3. The results will be expressed as a risk ratio for the binary outcome and as the mean difference or standardized mean difference for a continuous outcome. We will synthesize the data by either fixed effects or random effects model according to a heterogeneity test or the number of studies included in the meta-analysis. The methodological quality of the included studies will be evaluated using the Cochrane Collaboration's risk of bias tool. The quality of evidence for each main outcome will be evaluated using the Grading of Recommendations Assessment, Development, and Evaluation approach.

Ethics and dissemination:
Ethical approval is not required because individual patient data are not included. The findings of this systematic review will be disseminated through a peer-reviewed publication or conference presentations.

PROSPERO registration number:
CRD42018116559.
Combined airway and esophageal stents implantation for malignant tracheobronchial and esophageal disease
Authors: Bi Yonghua , Ren Jianzhuang , Chen Hongmei , Bai Liangliang , Han Xinwei , Wu Gang 
Published: January 2019

Abstract
We aimed to evaluate the safety and efficacy of combined airway and esophageal stents under fluoroscopy guidance and local anesthesia for patients with malignant tracheobronchial and esophageal disease. This retrospective analysis included 35 consecutive patients underwent combined stenting from March 2012 to August 2016. All patients underwent chest computed tomography scans before stenting and during follow-up. Thirty-nine airway stents and 43 esophageal covered stents were implanted. The indication of stenting, technical success and postinterventional complications were collected and analyzed. Thirty-nine airway stents and 43 esophageal covered stents were implanted. Stenting failed in 1 airway stent, and 2 esophageal stents, with technology success rates of 97.4% and 95.3%, respectively. No procedure-related death occurred, only 1 patient died from failure of respiration due to esophagotracheal fistula. The median interval between 2 stenting was 13.0 days. Both dyspnea and dysphasia were significantly relieved after stenting. Restenosis after stenting (7.7%) was the most common complication for airway stenting, all these cases required second stenting. Stent migration (7.0%) was the most common complication after esophageal stenting, 1 case had to receive airway stenting and 1 case received replacement of esophageal stent. During follow up, 23 patients were clinically cured, 2 patients were improved in symptoms, and 1 was invalid. Eight deaths were found in total. The 1-year, 3-year, and 5-year survival rates were 82.4%, 78.8%, and 78.8%, respectively. In conclusion, combined airway and esophageal stents implantation under fluoroscopy guidance and local anesthesia are safe and effective for malignant tracheobronchial and esophageal disease.
Factors associated with limited hand motion after hand trauma
Authors: Lee Jung Soo , Kim Yeo Hyung 
Published: January 2019

Abstract
Hand injuries are common and have a significant impact on daily life. However, the factors associated with functional outcome after hand injuries are not well established. The purpose of this study was to identify factors that are independently associated with hand total active motion (TAM).
A total of 50 patients with unilateral complex hand injury were included in this study. The associations between various demographic, injury-related, and clinical assessment factors and TAM were determined by univariate and multivariate linear regression analyses. Nerve injuries recognized during surgery and diagnosed with electrodiagnostic (EDX) studies were compared using Pearson chi-squared test.
Among multiple injury-related and initial clinical assessment factors, nerve injury diagnosed with EDX studies, hospital stay length, elevated C-reactive protein, and skeletal injury were independently associated with TAM in the affected hand after adjusting for covariates. Nerve injuries diagnosed with EDX studies were not consistent with those recognized during surgery.
Our results suggest that high-energy trauma leading to skeletal and nerve injury with inflammation is associated with limited hand motion after surgery and postoperative immobilization. A comprehensive EDX study may enable identifying occult or recovered nerve injuries, which would be helpful in understanding limitations in finger movements.
Herpes simplex virus linear endotheliitis in a post-keratoplasty patient
Authors: Shin Jeongah , Ra Ho , Rho Chang Rae 
Published: January 2019

Abstract

Rationale:
To report a case of herpes simplex virus (HSV) linear endotheliitis in a 57-year-old male who had underwent keratoplasty 10 years ago. The characteristic linear keratic precipitates (KPs) resembled the Khodadoust line in graft rejection. The differential diagnosis is essential, because the treatment regimen is different between HSV linear endotheliitis and graft rejection.

Patient concerns:
The patient developed a sudden onset of ocular pain and a decrease in visual acuity in his right eye. The patient had received penetrating keratoplasty in the eye 10 years ago.

Diagnoses:
The ocular disease was evaluated using several ocular examinations, including best-corrected visual acuity (BCVA), intraocular pressure, slit lamp examination, fundus examination, and aqueous humor tap. Characteristic linear endothelial KPs were found both in the host cornea and graft cornea. Stromal edema was evident in both the donor and recipient corneas. The aqueous humor was sampled for viral polymerase chain reaction (PCR) analysis. The sample was investigated for the possible presence of HSV I, HSV II, cytomegalovirus, and varicella zoster virus. The PCR was positive for HSV I and negative for HSV II, cytomegalovirus, and varicella zoster virus.

Interventions:
The patient was treated with both antiviral and steroid treatments for 1 month. Thereafter, prophylactic antiviral treatment was continued.

Outcomes:
The subjective symptoms had improved and the cornea edema and the linear endothelial KPs had disappeared. The BCVA improved from 20/200 to 20/80.

Lessons:
HSV linear endotheliitis is the most severe form of HSV endotheliitis. This case showed characteristic endothelial KPs, which were different from the Khodadoust line of graft rejection.
Laparoscopic pancreatoduodenectomy combined with portal-superior mesenteric vein resection and reconstruction with interposition graft
Authors: Wang Xin , Cai Yunqiang , Zhao Wei , Gao Pan , Li Yongbin , Liu Xubao , Peng Bing 
Published: January 2019

Abstract

Rationale:
With the development of laparoscopic techniques, laparoscopic pancreatoduodenectomy was applied in various indications including pancreatic cancer. Here, we share our experience of venous resection and reconstruction with interposition graft in laparoscopic pancreatoduodenectomy in these patients.

Patient concerns:
We reviewed data of laparoscopic pancreatoduodenectomy with venous resection and reconstruction in patients with pancreatic cancer between the dates of October 2010 and November 2017.

Outcomes:
Ten patients underwent laparoscopic pancreatoduodenectomy with portal-superior mesenteric vein resection and reconstruction with interposition graft. The mean operative time was 547 min. The mean blood loss was 435 ml. The mean length of venous defect after resection was 5.4 cm. R0 resection was achieved in nine patients (90%). There was one patient who suffered from severe postoperative complication. There was no 30-day mortality in this study. The long-term patency was achieved in all patients.

Conclusion:
In this study, we demonstrate the initial experience of laparoscopic pancreaticoduodenectomy with long venous resection and reconstruction. Although applied in small number of patients, it could be another option for well-selected patients with reasonable morbidity and mortality as well as long-term outcomes in experienced minimally invasive surgical team.
Bidirectional Links Between Social Rejection and Sleep
Authors: Gordon Amie M. , Del Rosario Kareena , Flores Abdiel J. , Mendes Wendy Berry , Prather Aric A. 
Published: January 2019

ABSTRACTObjectiveThis set of studies examines the bidirectional links between social rejection and poor sleep, a ubiquitous and increasingly problematic health behavior.MethodsIn study 1, a multiday field experiment, 43 participants completed a neutral task just before sleep on night 1 and a social rejection task on night 2. Objective and subjective sleep, postrejection affect, and physiological responses were measured. In study 2, 338 participants reported typical sleep quality before coming to the laboratory where they received social rejection or social acceptance feedback from a stranger. Physiological and affective responses were measured throughout the session.ResultsIn study 1, after social rejection, participants took longer going to bed (M [SD] = 38.06 [48.56] versus 11.18 [15.52],t(42) = 3.86,p< .001) and had shorter sleep durations (6:46 [1:27] versus 7:19 [1:38],t(41) = 2.92,p= .006) compared with the baseline night. Trait rumination moderated these effects, with high ruminators taking the longest to go to bed postrejection (t(38) = 2.90,p= .006). In both studies, there was (inconsistent) evidence that sleep influences reactions to rejection: some sleep measures predicted physiological reactivity during the rejection task in study 1 and greater negative affect after social rejection in study 2.ConclusionsThese studies provide evidence that social rejection may affect sleep outcomes, particularly for trait ruminators, and poor sleep in turn may exacerbate affective responses to social rejection. Given the mixed findings, small sample size, and no active control condition, more work is needed to confirm and build on these findings.
Rapidly Growing and Asymptomatic Skull Base Lesion
Authors: Tolisano Anthony M. , Lin Kevin , Hunter Jacob B. 
Published: January 2019

Abstract
Trochlear schwannomas typically present with diplopia and are extremely rare benign intracranial neoplasms that require the combined expertise of neurotologists and neurosurgeons for surgical excision. A combined petrosal approach offers a surgical route for removal of growing and/or symptomatic tumors. A study of a trochlear nerve schwannoma that demonstrated rapid growth but was otherwise asymptomatic was presented in this study.
10Kin1day: A bottom-up neuroimaging initiative
Authors: van den Heuvel Martijn P , Scholtens Lianne H , van der Burgh Hannelore K , Agosta Fredica , Alloza Clara , Avancini Tiffany M C , Baron-Cohen Simon , Basaia Silvia , Benders Manon JNL , Beyer Frauke , Booij Linda , Braun Kees PJ , Cahn Wiepke , Cannon Dara M , Chan Sandra SM , Chen Eric YH ,   Cambridge Child Development Project Consortium includes: Auyeung Bonnie; Holt, Rosemary J, Lombardo Michael V , Crespo-Facorro Benedicto , Crone Eveline A , Dannlowski Udo , de Zwarte Sonja MC , Diaz-Zuluaga Ana M , Dietsche Bruno , Du Plessis Stefan , Durston Sarah , Emsley Robin , Filho Geraldo B , Filippi Massimo , Frodl Thomas , Gąsecki Dariusz , Goc Joanna , Gorges Martin , Graff Beata , Grotegerd Dominik , Hall Julie M , Holleran Laurena , Hopman Helene J , Jäncke Lutz , Jansen Andreas , Jodzio Krzysztof , Kaleda Vasiliy G , Kassubek Jan , Masouleh Shahrzad Kharabian , Kircher Tilo , Koevoets Martijn GJC , Kostic Vladimir S , Krug Axel , Lawrie Stephen M , Lebedeva Irina S , Lee Edwin HM , Lett Tristram A , Lewis Simon JG , Liem Franziskus , Lopez-Jaramillo Carlos , Margulies Daniel S , Markett Sebastian , Marques Paulo , Martínez-Zalacaín Ignacio , McDonald Colm , McIntosh Andrew , McPhilemy Genevieve , Meinert Susanne L , Menchón José M , Mérillat Susan , Montag Christian , Moreira Pedro S , Morgado Pedro , Mothersill David Omar , Müller Hans-Peter , Nabulsi Leila , Najt Pablo , Narkiewicz Krzysztof , Naumczyk Patrycja , Neggers Sebastiaan WF , Oranje Bob , Foz Victor Ortiz-Garcia de la , Peper Jiska S , Pineda Z. Julian A , Rasser Paul E , Redlich Ronny , Repple Jonathan , Reuter Martin , Rosa Pedro GP , Ruigrok Amber NV , Sabisz Agnieszka , Schall Ulrich , Seedat Soraya , Serpa Mauricio H , Shook Devon , Skouras Stavros , Soriano-Mas Carles , Sousa Nuno , Szurowska Edyta , Tomyshev Alexander S , Tordesillas-Gutierrez Diana , Tozzi Leonardo , Valk Sofie L , Berg Leonard H van den , Erp Theo GM van , Haren Neeltje EM van , Leeuwen Judith JMC van , Villringer Arno , Vinkers Christiaan , Vollmar Christian , Waller Lea , Walter Henrik , Whalley Heather C , Witkowska Marta , Witte Veronica A , Zanetti Marcus V , Zhang Rui , Donohoe Gary , O’Keane Veronica , Lange Siemon C de 
Published: January 2019

AbstractWe organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain.
Auditory-Visual Interactions in the Blind with Artificial Vision: Are Multisensory Perceptions Restored After Decades of Blindness?
Authors: Stiles Noelle R. B. , Patel Vivek R. , Weiland James D. 
Published: January 2019

AbstractIn the sighted, auditory and visual perception typically interact strongly and influence each other significantly. Blindness acquired in adulthood alters these multisensory pathways. During blindness, it has been shown that the senses functionally reorganize, enabling visual cortex to be recruited for auditory processing. It is yet unknown whether this reorganization is permanent, or whether auditory-visual interactions can be re-established in cases of partial visual recovery.Retinal prostheses restore visual perception to the late blind and provide an opportunity to determine if these auditory-visual connections and interactions are still viable after years of plasticity and neglect. We tested Argus II retinal prosthesis patients (N = 7) for an auditory-visual illusion, the ventriloquist effect, in which the perceived location of an auditory stimulus is modified by the presence of a visual stimulus. Prosthetically-restored visual perception significantly modified patients’ auditory perceptions, comparable to results with sighted control participants (N = 10). Furthermore, the auditory-visual interaction strength in retinal prosthesis patients exhibited a significant partial anti-correlation with patient age, as well as a significant partial correlation with duration of prosthesis use.These results indicate that auditory-visual interactions can be restored after decades of blindness, and that auditory-visual processing pathways and regions can be re-engaged. Furthermore, they indicate the resilience of multimodal interactions to plasticity during blindness, and that this plasticity can either be partially reversed or at least does not prevent auditory-visual interactions. Finally, this study provides hope for the restoration of sensory perception, complete with multisensory integration, even after years of visual deprivation.SignificanceRetinal prostheses restore visual perception to the blind by means of an implanted retinal stimulator wirelessly connected to a camera mounted on glasses. Individuals with prosthetic vision can locate and identify simple objects, and identify the direction of visual motion. A key question is whether this prosthetic vision will interact with the other senses, such as audition, in the same way that natural vision does. We found that artificial vision, like natural vision, can alter auditory localization. This suggests that the brain processes prosthetic vision similarly to natural vision despite altered visual processing in the retina. In addition, it implies that reorganization of the senses during blindness may be reversible, allowing for the rehabilitation of crossmodal interactions after visual restoration.
Design principles for open source bioinstrumentation: the poseidon syringe pump system as an example
Authors: Sina Booeshaghi A. , da Veiga Beltrame Eduardo , Bannon Dylan , Gehring Jase , Pachter Lior 
Published: January 2019

ABSTRACTThe poseidon syringe pump and microscope system is an open source alternative to commercial systems. It costs less than $400 and can be assembled in under an hour using the instructions and source files available at https://pachterlab.github.io/poseidon. We describe the poseidon system and use it to illustrate design principles that can facilitate the adoption and development of open source bioinstruments. The principles are functionality, robustness, simplicity, modularity, benchmarking, and documentation.
The genomic sequence and comparative genomic analysis of cultivated passion fruit(Passiflora edulis L.)
Authors: Wu Yanyan , Tian Qinglan , Liu Jieyun , Huang Yongcai , Huang Weihua , Xia Xiuzhong , Mou Haifei , Yang Xinghai 
Published: January 2019

AbstractCultivated passion fruit is a fruit tree widely cultivated in southern China, but little is known about its genomics, which seriously restricts the molecular genetics research of passion fruit. In this study, we analyzed the 165.7Mb representative genome sequences. The results showed that the passion fruit genome contained a large number of simple sequence repeats (SSR). Compared to the cassava and peach genomes, the passion fruit genome has 23,053 predicted genes. These genes can be aligned to 282 plant genomes. GO annotation indicated that these genes are involved in metabolic pathways of carbohydrates, organic acids, lipids and other molecules. KEGG pathway enrichment assigned these genes into five major categories and 19 secondary functions. Cluster analysis of gene families showed that 12,767 genes could be clustered into 9,868 gene families and 291 unique gene families. On the evolutionary relationship, the passion fruit is closely related to Populus trichocarpa and Ricinus communis, but the rate of evolution is slower. In summary, this genomic analysis result is informative, and will facilitate the future studies on gene functions of passion fruit.
Regulation of modulatory cell activity across olfactory structures in Drosophila melanogaster
Authors: Zhang Xiaonan , Coates Kaylynn , Dacks Andrew , Gunay Cengiz , Scott Lauritzen J. , Li Feng , Calle-Schuller Steven A. , Bock Davi , Gaudry Quentin 
Published: January 2019

AbstractAll centralized nervous systems possess modulatory neurons that arborize broadly across multiple brain regions. Such modulatory systems are critical for proper sensory, motor, and cognitive processing. How single modulatory neurons integrate into circuits within their target destination remains largely unexplored due to difficulties in both labeling individual cells and imaging across distal parts of the CNS. Here, we take advantage of an identified modulatory neuron in Drosophila that arborizes in multiple olfactory neuropils. We demonstrate that this serotonergic neuron has opposing odor responses in its neurites of the antennal lobe and lateral horn, first and second order olfactory neuropils respectively. Specifically, processes of this neuron in the antennal lobe have responses that are inhibitory and odor-independent, while lateral horn responses are excitatory and odor-specific. The results show that widespread modulatory neurons may not function purely as integrate-and-fire cells, but rather their transmitter release is locally regulated based on neuropil. As nearly all vertebrate and invertebrate neurons are subject to synaptic inputs along their dendro-axonic axis, it is likely that our findings generalize across phylogeny and other broadly-projecting modulatory systems.SignificanceThe centrifugal innervation of neuronal circuits is ubiquitous across centralized nervous systems. Such inputs often arise from modulatory neurons that arborize broadly throughout the brain. How information is integrated in such cells and how release from their distant terminals is regulated remains largely unknown. We show that a serotonergic neuron that innervates multiple stages of odor processing in Drosophila has distinct activity throughout its neurites, including opposite polarity responses in first and second order olfactory neuropils. Disparate activity arises from local interactions within each target region. Our results show that such neurons exhibit dendritic computation rather than somatic integration alone, and that examining local interactions at release sites is critical for understanding centrifugal innervation.