bluuebunny/crossref_metadata_2025_split huggingface dataset:
PO-281 Vibration Training Restores Food Intake and Body Weight in a Rat Model of Depression
Authors: Peng Guangcong , Yang Luodan , Wu Chongyun , Hou Jun , Zhang Limei , Xiao Mengyun , Wu Chunyi , Zhang Quanguang 
Published: October 2018

Objective Stress is well known to negatively affect body weight and food intake in animal models, but the underlying mechanisms have not yet been well elucidated and effective treatment is lacking. This project was initiated to study the potential beneficial effect of vibration training, a novel neuromuscular training method, in the treatment of depression.
Methods Adult Sprague-Dawley male rats were randomly divided into the following three groups: 1) naïve control group, 2) depressive disorder group, and 3) depression with vibration training treatment group. To develop a depression phenotype, rats were individually and gently restricted in a modified, well-ventilated tube for 4 h every day for 21 days. Animals in vibration training treatment group were subjected to 30 min of vibration training (30 Hz, 5 days / week) for continuous 5 weeks. Body weight, physical and mental condition, and food intake were recorded daily and the data were statistically analyzed and compared between groups.
Results 1. Daily body weight and food intake measurements revealed that both parameters decreased rapidly after the initiating daily restraint stress, compared with control group. Intriguingly, both body weight and food intake of the depressive disorder group with 5-week vibration training were significantly improved. 2. The secretion of serotonin and dopamine in animals with chronic restraint stress were decreased compared with normal animals, and this attenuation was significantly prevented by vibration training.
Conclusions The present study demonstrates that vibration training is capable of restoring food intake and body weight in a rat model of chronic restraint stress-induced depression.
PO-289 Lipidomic analysis of blood serum from prepubertal boys with different BMI
Authors: Cao Yuping , Yan Yi , Xie Minhao 
Published: October 2018

Objective Childhood obesity is a worldwide health problem which may causes metabolic diseases such as hyperglycemia, hyperlipidemia, hypertension and hyperuricemia. It is well know that lipid metabolites regulate fatty acid and glucose homeostasis. Lipidomics is the comprehensive analysis of lipid metabolites which include their quantitation and metabolic pathways. The intention of this study is to identify the circulating lipid species which are altered in obese prepubertal boys.
Methods A total number of 72 boys aged 10.28 ±0.69 years old were included into this study, and divided into normal(NC), overweight(OW) and obese group(OB). The degree of maturation of all boys were measured by bone age and sex hormones. Then we measured the form indexes, blood lipids, blood glucose level to identify the current state of all boys. Serum indexes were detected by CLIA and ELISA methods. A lipidomic method was established by using a Waters Acquity UPLCI-Class liquid system combined with Waters Xevo G2-SQ-TOF mass spectrometry system. The identification and analysis of lipid metabolites were complished by using MassLynx 4.1, Progenesis QI software and LipidMaps database. Statistical analyzes were performed using SPSS22.0 software.
Results (1)The waist-to-hip ratio, bone age and HDL-c levels ware significant lower in OW and OB groups. The TG level was significant higner in OB group. The DHEA and SHBG levels was significant higner in OW and OB groups and the other sex hormones are not .
(2) In this study, 153 most significant different lipid metabolites were founded, incluing 3 diacylglycerol, 32 triglyceride, 1 Phosphatidyl cholines, 1 Phosphatidylinositol, 3 Sphingomyelin, 1 Ceramide which significant higher in OW&OB group; 4 diacylglycerol, 17 Phosphatidic acid, 32 Phosphatidyl cholines, 4 Phosphatidylinositol, 13 Phosphatidylserine, 18 Phosphatidyl ethanolamine, 3 Phosphoglycerides, 13 Sphingomyelin and 6 Ceramide which significant lower in OW&OB group.
Among all this metabolites, 8 lipids (fold change ≥5) were founded as the significant biomarkers related prepubertal obesity , including 1 Phosphatidyl cholines, 1 phosphatidylserine, 2 sphingomyelin and 4 Triglyceride. What’s more, the level of SM(d16:1/24:0) and TG(15:0/17:1/20:3) which measured by UPLC-QTOF/MS are highly positive correlated with the level of serum SHBG; PC(18:0/0:0) and TG(16:1/18:0/20:3) are highly negtive correlated with serum SHBG.
Conclusions Overweight and obese prepubertal boys showed disorder in lipid metabolism and bone growth. The lipidomic results showed lower SHBG level is related with the disorder of lipid metabolism. We suggest that further studies on these metabolites could help us gain a better understanding of the relationship between obesity and growth disorder.
PO-290 Discussing and Exploring about Mobile Quick Recovery Strategy for General Games——Quick Recovery Measure Applied on the 13th National Games
Authors: Liu Yong , An Jianghong 
Published: October 2018

Objective Multiple quick recovery methods are used in the training and competition fields to explore quick recovery programs appropriate for application at the competition site, search for quick recovery form appropriate for competition characteristics of partial programs, and provide more science and technology measures for preparing for large sport, quickening the recovery of the athletes at the competition site, improving competitive capability and enhancing training and competition performance.
Methods Athletes in Beijing participating in partial programs of the 13th National Games are taken as the research object. According to training and competition characteristics of the program, and in combination with competition rules and conditions at the competition site, practice research is used to try to use nutritional supplement, whole-body cryotherapy (WBC), hyperbaric oxygen recovery, deep muscle stimulate (DMS), intermittent pneumatic compression (IPC) and music therapy and others at the training and competition sites, explore positive and effective quick recovery solutions, and establish a mobile quick recovery strategy for general games.
Results According to research results of all events in Beijing before the game, nearly 70% of sports teams are in urgent need of corresponding quick recovery support and guarantee; it’s proven through practice and application in the 13th National Games, mobile quick recovery strategy can be used during preparation before the game, so as to activate the muscle in an accelerated way, improve nerve excitability and enhance warm-up effect; in the break of many matches in one day, it can be used to calm down, quickly supplement energy substances, speed up the elimination of metabolites, relieve muscle fatigue, quickly restore physical functions, and prepare well for the next match; if competition is required in consecutive days, it can be used during recovery after the end of daily competition, to timely supplement energy substances consumed in competition, eliminate metabolites, improve sleep, accelerate anabolism, fully restore physical functions and ensure good state in the competition
Conclusions With the principle of quickening muscle relaxation and fatigue elimination and in the form of “quick recovery mobile service station”, during preparation before competition, interval and after the competition, mobile quick recovery strategy can be used, i.e. multiple quick recovery measures are used at the competition site to promote fatigue elimination and physical recovery of the athletes, achieve good results, provide strong operability and good promotion value, so as to provide a new thought and selection for preparing for large games, speeding up recovery of athletes at the competition site, improving competitive capability and enhancing training and competition performance.
PO-291 Applied Research on Enhancing Respiratory Muscle Strength of Synchronized Swimmers by Using Respiratory Muscle Trainer
Authors: An Jianghong , Fan Yuncai 
Published: October 2018

Objective In research to date , powerbreath training to be tested were useful to improve the athletics’ ability for training the breathe muscles, by the way to optmizing the Breathing technique.To further improve the synchronize swimming athletes’ powerbreath of BeiJing,tenhancing the athletics level and express ability of whole team, to succeed in the finals.
Methods Six synchronize swimming athletes were the subjects of our research,the training takes place after the strength training,two times per week, 10 times of five weeks.the training frequency were 24~32 per minutes.At this stages we tested the changes of the breathe muscle by use the CHEST H-101 and Powerbreath K3 before and after the training.All the data were analyzed using SPSS17.0 software.
Results The research results shows, training the breathe muscle by spirotiger is the useful training methods to improve the synchronize swimming athletes’s powerbreath.By five weeks training,the synchronize swimming athletes’ lung volume capacity were significantly increased from 4.38L to 4.54L after powerbreath training, the rate of the enhancing were 3.65%、 FVC were significantly increased from 3.80Lto 3.93L after powerbrath training, the rate of the enhancing were 2.89%、MVVwere significantly increased from 122.2L/min to 127.1L/min, the rate of enchancing were 4.0%, the strength of inspiratory muscle were significantly increased from 110.6cmH2O to 125.6cmH2O, the flow of inspiratory muscle were significantly increased from 6.2L/S to 6.8L/S. All the datas shows that the power of the breathe muscles were enhancing efficenicy after five weeks systematic training,and the variation rate of individual research shows that there were difference between the individuls.
Conclusions After five weeks systematic breathe muscle training,FVC and MVV were significantly increased ,shows the synchronize swimming athletes’ respiration muscle strength were significantly increased; the index were significantly increased of the strength of inspiratory muscle also shows that the breath muscle training were enficiency,and the training plan is helpful to enhancing the synchronize swimming athletes’ powerbreath.
PO-292 Exercise Delays Alzheimer's Disease Through Enhancing Lysosomal Function
Authors: Lin Fang , Wang Xue , Huang Jun , Zhu Yu Ting , Qin Zheng Hong , Li Zhe 
Published: October 2018

Objective Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by aggregation of amyloid-β (Aβ) peptides. Reduction of progressive accumulation of Aβ will delay the progression of AD. As a main digestive organelles in cells, lysosome is crucial to clear the harmful proteins from extracellular and intracellular. Recent evidences have shown that exercise improves cognitive function of AD, but the reason is not very clear. This manuscript is to study the effect of long-term running exercise training on lysosomal function in mouse brain and explore its relationship with the progress of Alzheimer’s disease.
Methods the APP/PSEN1 transgenic mice were used as the AD model to examine the relationship between AD, exercise and lysosomes. The mice were trained on a treadmill from the 5 months old, 60 min/day and 5 days/week for 5 months. The Lashley water maze and the novel object recognition test were used to estimate the cognitive ability of the mice; the balance beam and the rotating rod experiment were used to estimate motor coordination. The Aβ accumulation was measured with brain section and immunochemistry. The effects of long-term exercise on lysosomal function of cerebral cortex, striatum and hippocampus were measured. Among them, the autophagy/lysosome associated proteins level was determined by Western blot and the autophagy vacuoles and lysosome were observed through electron microscope. TFEB nuclear translocation was determined by Western blot and Immunofluorescence. The transcription of the TFEB-regulating genes were determined by quantitative PCR (qPCR).
Results Long-term exercise improved the cognitive ability and physical coordination of AD transgenic mice. Exercise reduced Aβ accumulation through increase the clearance of Aβ and affected little on the production of Aβ. Exercise, not only increased the colocalization of lysosomes with Aβ, but also increased the mature type of lysosomal protease cathepsin D and cathepsin L. In the meanwhile, exercise promoted the nuclear translocation of TFEB, a master transcriptional regulator of lysosomal biogenesis and autophagy, and increased the transcription of genes associated with the biogenesis of lysosome.
Conclusions Long-term exercise training delays the progress of Alzheimer's disease through activating function of lysosome and enhancing the biogenesis of lysosome. Exercise may be a therapeutic approach for the treatment of Alzheimer's disease.
PO-294 Effects of HIIT on FTO protein expression and its relationship with glucose and fat metabolism
Authors: Xu Chunyan , Zhao Juan , Duan Jiayan 
Published: October 2018

Objective FTO (Fat mass and obesity-associated) is associated with increased risk of obesity and type 2 diabetes incurrence. Studies have shown that the expression of FTO protein in skeletal muscle and adipose tissue is related to the oxidation rate of whole body substrate. With the increase of age, the body's carbohydrate oxidation rate decreases, the fat oxidation rate increases, and at the meanwhile the expression of FTO protein in skeletal muscle decreases and that in adipose increases. HIIT is very helpful for inhibiting obesity, insulin resistance and type 2 diabetes. So the purpose of this study is to investigate the effect of HIIT exercise on the expression of FTO protein in rats and its relationship to glucose and fat metabolism.
Methods 20 Male, 3-week-old SD rats were randomly divided into two groups, each group has 10 rats. C group: sedentary; HIIT group: high-intensity intermittent training group (85% ~ 90% VO2max exercise for 6min, 50% VO2max exercise interval 4min, repeated 6 times. 5 times/week ,4 weeks). All subjects were maintained in a free facility with constant temperature of 25°C, light-dark cycle of 12/12 h and free access to water. 48 hours after the last exercise, all samples were taken with an overnight fast. The expression of FTO protein in skeletal muscle and adipose tissue was measured by Western Blot. Serum insulin was tested by ELISA; Estimation of blood glucose was tested by Glucose oxidase method.
Results 1.The expression of FTO protein in skeletal muscle was significantly higher than that of group C (P <0.01); The expression of FTO protein in adipose tissue of HIIT group was significantly lower than that of group C (P <0.05); 2. Serum insulin levels of group HIIT was significantly lower than that of group C (p <0.01); And the blood glucose of group HIIT was significantly lower than that of group C (p <0.01). 3. Serum LDL-C of group HIIT was significantly lower than that of group C (p <0.01), and serum HDL-C of group HIIT was significantly higher than that of group C (p <0.01);4. Correlation analysis showed that serum insulin level was negatively correlated with skeletal muscle FTO protein expression (R = -0.454, p < 0.05). Correlation analysis showed that serum LDL-C levels was positively correlated with adipose tissue FTO protein expression (R=0.559, p < 0.05) and serum HDL-C levels was negatively correlated with adipose tissue FTO protein expression (R=-0.474, p < 0.05).
Conclusions 1. HIIT can increase the protein expression of FTO in rat skeletal muscle and decrease the expression of FTO protein in adipose tissue; 2. HIIT can regulate glucose metabolism and lipid metabolism in rats; 3. The regulation of glucose metabolism by HIIT may be related to the increase of FTO protein expression in skeletal muscle. The regulation of lipid metabolism may be related to the reduction of FTO protein expression in adipose tissue.
PO-296 Sex differences in the change of amino acid and cortisol concentration after marathon race
Authors: Zhou Chunhua , Li Meng , Chen Song , Du Yutao 
Published: October 2018

Objective As we all know, marathon exercise can induce dramatic changes in amino acid and hormone concentration in the plasma. However, little attention has been given to the role of sex in metabolic changes.
Methods We compared the changing rates of amino acid and hormone after marathon running in male and female runners. Twenty-seven female (mean age: 41±15 years) and 66 male (mean age: 40±16 years) non-professional runners performed a marathon race. Amino acid and cortisol levels were assessed before and at 1h after race.
Results At pre-race and post-race, cortisol concentrations in female runners were lower than in males. Cortisol increased in all subjects at post-race but the rising rate was substantially higher (P<0.05) in females [median (range): 3.5 (21~ -0.25)] than in males [median (range): 2.09 (14.3~-0.43)]. Post-race, the glycogenic amino acid concentrations of Arg, Asn, Gly, Ile, Met, Ser and Thr were significantly decreased in females and males. But females have higher decreased rate (P<0.02) [median (range):Arg -45% (12%~ -69%), Asn -42% (25%~ -72%), Gly -45% (5%~ -73%), Ile -35% (16%~ -64%), Met -28% (48%~ -62%), Ser -34% (17%~ -58%), Thr -33%(32%~ -52%)] than males [median (range):Arg -35% (65%~ -64%), Asn -29%(46% ~ -59%), Gly -33% (13%~ -64%), Ile -23% (37%~ -57%), Met -14% (92%~ -52%), Ser -23% ( 21%~ -56%), Thr -17% ( 84%~ -58%)]. This is because, during exercise, cortisol has the function of inducing gluconeogenesis to maintain plasma glucose supply.
Conclusions There is significant sex differences in the change of cortisol and some glycogenic amino acid concentration before and after marathon race, which has potential value for training and nutrition supplement in marathon running.
PO-298 Effect of exercise and Siyeshen upon hippocampal cytochrome c and caspase-3 of diabetic rats
Authors: Wang Dongmei , Zhang Jinming , Liu Haibin , Wang Rongmei 
Published: October 2018

Objective To observe the effects of aerobic exercise and Siyeshen water extract on cytochrome c (Cyt c) and caspase-3 in hippocampus of diabetic rats and to explore the possible mechanism of improving diabetes.
Methods Healthy male Wister rats fed with high fat and high sugar and combined with streptozotocin to establish type II diabetes model. They were randomly divided into 4 groups: diabetic control group, exercise group, Siyeshen group and exercise+Siyeshen group, and another normal control group, with 6 rats in each group. After aerobic exercise (15m/min, 5°slope, 60min, every other day) or/and Siyeshen (200mg/kg) gastrointestinal administration for 8w, the expression of Cyt c and caspase-3 in hippocampus of each group were detected by immunoblotting, and mRNA expressions were detected by RT-PCR.
Results Compared with the normal control group, the mRNA and protein expressions of Cyt c and caspase-3 in the hippocampus of the diabetic control group were significantly increased (P<0.05). Compared with the diabetic control group, the blood glucose level of exercise group and exercise+ Siyeshen group decreased (P<0.05), the mRNA and protein expression of Cyt c and caspase-3 decreased significantly (P<0.05), but there were no significant changes in the mRNA and protein expression of Cyt c and caspase-3 between Siyeshen group and diabetic control group (P﹥0.05).
Conclusions Exercise and exercise combined with Siyeshen can inhibit cytochrome c release and reduce caspase-3 protein expression, which may be related to the improvement of blood glucose levels in diabetic rats.
PO-208 Effect of resistance training on functional fitness and bone mineral density in elderly women
Authors: Sun Jinqiu , Tan Jingjing 
Published: October 2018

Objective Try to carry out the intervention experiment of the strength exercise of the elderly in the community, aiming to provide theoretical and data basis for the daily strength exercises of the elderly in China.
Methods Recruiting 18 elderly female volunteers in Xicheng District, Beijing, required independent living ability and were willing to participate in the experiment. They were randomly divided into intervention group (N=9, 62.0±6.0 years) and control group (N=9, 63.0 ± 4.8 years). On Tuesday afternoon and Thursday morning, under the leadership of a professional coach, follow the planned "Resistance Exercise Plan" to carry out resistance training. Each practice time is about 90min for 9 weeks. The exercise intensity control is divided into two phases: the first phase lasts for one week, mainly the learning and adaptation phase of the action, and the heart rate control in the 30%~40%HRR or RPE 10 subscale is 4 (a little easy); The stage lasts for 8 weeks of the medium-intensity practice phase, the heart rate control in the 40%~60%HRR or RPE 10 subscale is 5~6 (moderate, slightly strenuous).
Results Intervention group before and after experiment, the grip strength (25.0±5.0 VS 26.8±3.9 kg, P<0.05) and the 30s arm curl test (23.1±5.2 VS 25.4±4.0 reptitions, P<0.05) increased. Five sit-up tests (6.99±2.01 VS 6.51±2.00 s, P<0.05) and the 8-foot standing walk (5.13±1.03 VS 5.07±1.01 s, P<0.05) were all shortened. The bone density T value (-1.3±0.4 VS -1.0±0.4, P<0.05) increased. After intervention, the intervention group compared with the control group, grip strength (26.8 ± 3.9 VS 22.1 ± 4.5 kg, P <0.05), 30s arm curl test(25.4 ± 4.0 VS 22.1 ± 3.0 reptitions, P <0.05) increased. Five sit-up tests (6.51 ± 2.00 VS 6.94 ± 1.05 s, P < 0.05) and 8 feet of standing walk (5.07 ± 1.01 VS 5.27 ± 0.97 s, P < 0.05) were all shortened. Bone density T value (-1.0 ± 0.4 VS - 1.4 ± 0.4, P < 0.05) increased. There was no significant change in the 30-second chair stand test.
Conclusions Through 9 weeks of progressive resistance exercise, the experiment made the upper limb explosive force, upper limb muscle endurance, lower limb explosive power, flexibility and dynamic balance enhanced, and bone density increased. The enhancement of lower limb endurance is not obvious, which may be the reason for short experimental time and small exercise intensity of lower limbs.
PO-219 Experimental study on exercise intervention to improve cardiac risk during exercise in men aged 40~49 years
Authors: Huang Jianya , Cao Jianmin , Xie Minhao , Lin Jiashi , Li Sen , Tang Qiang 
Published: October 2018

Objective Through 12 weeks exercise interventions of different exercise volume (1200kal/w or 2000kcal/w) on 40-49 years old male subjects，trying to explore the effect of exercise intervention on the d risk indicators of ECG (ST、QTcd) during the exercise, to provide a scientific basis for the public health in the future .
Methods The subjects were randomly divided into 3 groups. (1)control group (n=9); (2) low volume group (n=7); (3) high volume group (n=8). The exercise group exercise intervention lasted 12 weeks. The indices of HRV at rest and risk indices of ECG (ST、QTcd)during exercise.
Results (1) Compared the underdraught of ST segment during exercise before and after the intervention, we found that exercise intervention did not produce significant change, and QTcd during the exercise in both high and low volume group after the intervention was significantly lower than before (P <0.05). (2) Compared the difference of ECG indices during exercise before and after, we found that descender of QTcd in low volume was significantly higher than the control group (P<0.05), while the descender of QTcd in high group was very significantly higher than the control group (P<0.01). The difference of ST segment in different group did not have significantly change.
Conclusions (1) 12 weeks exercise intervention (intensity of 65-80% VO2max, exercise volume of 2000kcal/w) has no effect under the pressure amplitude of the ST segment during the exercise. (2) 12 weeks exercise intervention (intensity of 65-80% VO2max, exercise volume of 2000kcal/w) produce QTcd during exercise significantly reduced, reducing the risk of exercise-induced myocardial ischemia.