bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decolonising our minds: what UK psychiatry needs to (un)learn
Authors: Satram Venkatalakshmi 
Published: November 2024

SummaryThe dominance of Western orthodox models of psychiatry has led to colonisation of the mind and marginalisation of diverse cultural conceptualisations of distress and forms of caring. Compounded by a crisis of care and chronic underfunding, this has also diminished our practice here in the UK. This article probes the biases that UK psychiatry must unlearn and what lessons it can learn from decolonising praxes originating in the Global South. This is a call to action. We must transform our mindsets and advocate for contextualised, collective, integrative and socially just mental healthcare in the UK.
Successful Multimodal Treatment of Locally Advanced Parathyroid Carcinoma
Authors: Kim Na Hyun , Kim Chae A , Chung Sae Rom , Chung Ki-Wook , Kim Won Gu , Jeon Min Ji 
Published: November 2024

Abstract
Parathyroid carcinoma is a rare endocrine malignancy for which the primary treatment is surgery; however, 50% of the patients develop local recurrence or distant metastases. No consensus exists on the standard treatment for metastatic parathyroid cancer. Here we report a case of a 41-year-old male with inoperable locally advanced parathyroid carcinoma who was successfully treated with multimodal therapy including radiofrequency ablation (RFA), external beam radiation therapy (EBRT) to the neck, and sorafenib. Eleven months after initiating sorafenib, serum calcium levels were normal, and both the intact PTH level and the size of metastatic lesion remained stable; thus, we decided to discontinue sorafenib. After discontinuation, the disease remained stable for 18 months and continues to be so. Hence, clinicians can consider multimodal treatment with RFA, EBRT, and sorafenib as a treatment option for locally advanced parathyroid carcinoma.
Comprehensive Morphometric Analysis to Identify Key Neuroimaging Biomarkers for the Diagnosis of Adult Hydrocephalus Using Artificial Intelligence
Authors: Gholampour Seifollah , Rosen Jacob Benjamin , Pagan Michelangelo , Chen Sonja , Gomaa Ibrahim , Dehghan Arshia , Waterstraat Mark Graham 
Published: November 2024

BACKGROUND AND OBJECTIVES:
Hydrocephalus involves abnormal cerebrospinal fluid accumulation in brain ventricles. Early and accurate diagnosis is crucial for timely intervention and preventing progressive neurological deterioration. The aim of this study was to identify key neuroimaging biomarkers for the diagnosis of hydrocephalus using artificial intelligence to develop practical and accurate diagnostic tools for neurosurgeons.

METHODS:
Fifteen 1-dimensional (1-D) neuroimaging parameters and ventricular volume of adult patients with non-normal pressure hydrocephalus and healthy subjects were measured using manual image processing, and 10 morphometric indices were also calculated. The data set was analyzed using 8 machine, ensemble, and deep learning classifiers to predict hydrocephalus. SHapley Additive exPlanations (SHAP) feature importance analysis identified key neuroimaging diagnostic biomarkers.

RESULTS:
Gradient Boosting achieved the highest performance, with an accuracy of 0.94 and an area under the curve of 0.97. SHAP analysis identified ventricular volume as the most important parameter. Given the challenges of measuring volume for clinicians, we identified key 1-D morphometric biomarkers that are easily measurable yet provide similar classifier performance. The results showed that the frontal-temporal horn ratio, modified Evan index, modified cella media index, sagittal maximum lateral ventricle height, and coronal posterior callosal angle are key 1-D diagnostic biomarkers. Notably, higher modified Evan index, modified cella media index, and sagittal maximum lateral ventricle height, and lower frontal-temporal horn ratio and coronal posterior callosal angle values were associated with hydrocephalus prediction. The results also elucidated the relationships between these key 1-D morphometric parameters and ventricular volume, providing potential diagnostic insights.

CONCLUSION:
This study highlights the importance of a multifaceted diagnostic approach incorporating 5 easily measurable 1-D neuroimaging biomarkers for neurosurgeons to differentiate non-normal pressure hydrocephalus from healthy subjects. Incorporating our artificial intelligence model, interpreted through SHAP analysis, into routine clinical workflows may transform the diagnostic landscape for hydrocephalus by standardizing diagnosis and overcoming the limitations of visual evaluations, particularly in early stages and challenging cases.
Binary Quantum Control Optimization with Uncertain Hamiltonians
Authors: Fei Xinyu , Brady Lucas T. , Larson Jeffrey , Leyffer Sven , Shen Siqian 
Published: November 2024

Optimizing the controls of quantum systems plays a crucial role in advancing quantum technologies. The time-varying noises in quantum systems and the widespread use of inhomogeneous quantum ensembles raise the need for high-quality quantum controls under uncertainties. In this paper, we consider a stochastic discrete optimization formulation of a discretized binary optimal quantum control problem involving Hamiltonians with predictable uncertainties. We propose a sample-based reformulation that optimizes both risk-neutral and risk-averse measurements of control policies, and solve these with two gradient-based algorithms using sum-up-rounding approaches. Furthermore, we discuss the differentiability of the objective function and prove upper bounds of the gaps between the optimal solutions to binary control problems and their continuous relaxations. We conduct numerical simulations on various sized problem instances based on two applications of quantum pulse optimization; we evaluate different strategies to mitigate the impact of uncertainties in quantum systems. We demonstrate that the controls of our stochastic optimization model achieve significantly higher quality and robustness compared with the controls of a deterministic model. History: Accepted by Giacomo Nannicini, Area Editor for Quantum Computing and Operations Research. Accepted for Special Issue. Funding: This work was supported by the US Department of Energy, Advanced Scientific Computing Research [Grants DE-AC02-06CH11357, DE-SC0018018]; Defense Sciences Office, DARPA [Grant IAA-8839-annex-130]; the US National Science Foundation, Division of Civil, Mechanical and Manufacturing Innovation [Grant 2041745]; and the US National Aeronautics and Space Administration (NASA) Ames Research Center [Grant 80ARC020D0010]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2024.0560 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2024.0560 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Three-point-supported 2-DOF large-area tilting mirror inspired by a playground facility
Authors: Chiang Ming-Te , Tsai Ming-Hsuan , Liu Guan-Yang , Tsai Jui-Che 
Published: November 2024

In this paper, we demonstrate a three-point-supported 2D optical scanner designed to
enhance the field of view (FoV) and optical scanning angles, and
facilitate the development of large mirrors (>10cm). By integrating fused deposition
modeling (FDM) 3D printing with electromagnetic driving, we present a
cost-effective, large-sized scanning mirror with two-dimensional
scanning capabilities. The mirror has an area of 144cm2, enabling greater light capture for
enhanced scanning performance. Under DC driving, the maximum optical
scanning angles are 5.99° in the x direction and 12.61° in the y
direction. For AC driving, the resonant scanning frequencies are
18.2 Hz for the x scan and 19 Hz for the y scan, with
maximum scanning angles of 7.87° for the x scan and 7.19° for the
y scan.
Optomechanical microgear cavity
Authors: Zurita Roberto O. , Kersul Cauê M. , Schilder Nick J. , Wiederhecker Gustavo S. , Alegre Thiago P. Mayer 
Published: November 2024

We introduce a novel optomechanical microgear cavity for both optical and mechanical isotropic materials, featuring a single-etch configuration. The design leverages a conjunction of phononic and photonic crystal-like structures to achieve remarkable confinement of both optical and mechanical fields. The microgear cavity we designed in amorphous silicon nitride exhibits a mechanical resonance at 4.8 GHz, and whispering gallery modes in the near-infrared, with scattering-limited quality factors above the reported material limit of up to 107. Notably, the optomechanical photoelastic overlap contribution reaches 75% of the ideal configuration seen in a floating ring structure.
Transition from quantum-to-classical random walk distributions with spin–orbit modes
Authors: Lamego V. S. , Cruz G. T. C. , Lima D. R. A. B. , Al-Kuwari S. M. , Huguenin J. A. O. 
Published: November 2024

Quantum walks (QW) offer a speed-up advantage over random walks in quantum search applications. We present an experimental study of the transition from quantum-to-classical random walk using an emulation of the decoherence process for polarization qubits that exploits maximally non-separable spin–orbit modes of an intense laser beam for the first, to the best of our knowledge, time. We are able to continuously control the input polarization mode in an all-optical quantum walk circuit to observe transitions associated with quantum, quantum stochastic, and classical random walk distributions. The results are in agreement with theoretical expectations.
The association of bearing surface materials with the risk of revision following primary total hip replacement: A cohort analysis of 1,026,481 hip replacements from the National Joint Registry
Authors: Whitehouse Michael R. , Patel Rita , French Jonathan M. R. , Beswick Andrew D. , Navvuga Patricia , Marques Elsa M. R. , Blom Ashley W. , Lenguerrand Erik 
Published: November 2024

Background
The risk of re-operation, otherwise known as revision, following primary hip replacement depends in part on the prosthesis implant materials used. Current performance evidences are based on a broad categorisation grouping together different materials with potentially varying revision risks.
We investigated the revision rate of primary total hip replacement (THR) reported in the National Joint Registry by specific types of bearing surfaces used.

Methods and findings
We analysed THR procedures across all orthopaedic units in England and Wales. All patients who received a primary THR between 2003 and 2019 in the public and private sectors were included. We investigated the all-cause and indication-specific risks of revision using flexible parametric survival analyses to estimate adjusted hazard ratios (HRs). We identified primary THRs with heads and monobloc cups or modular acetabular component THRs with head and shell/liner combinations.
A total of 1,026,481 primary THRs were analysed (Monobloc: n = 378,979 and Modular: n = 647,502) with 20,869 (2%) of these primary THRs subsequently undergoing a revision episode (Monobloc: n = 7,381 and Modular: n = 13,488).
For monobloc implants, compared to implants with a cobalt chrome head and highly crosslinked polyethylene (HCLPE) cup, the all-cause risk of revision for monobloc acetabular implant was higher for patients with cobalt chrome (hazard rate at 10 years after surgery: 1.28 95% confidence intervals [1.10, 1.48]) or stainless steel head (1.18 [1.02, 1.36]) and non-HCLPE cup. The risk of revision was lower for patients with a delta ceramic head and HCLPE cup implant, at any postoperative period (1.18 [1.02, 1.36]).
For modular implants, compared to patients with a cobalt chrome head and HCLPE liner primary THR, the all-cause risk of revision for modular acetabular implant varied non-constantly. THRs with a delta ceramic (0.79 [0.73, 0.85]) or oxidised zirconium (0.65 [0.55, 0.77]) head and HCLPE liner had a lower risk of revision throughout the entire postoperative period.
Similar results were found when investigating the indication-specific risks of revision for both the monobloc and modular acetabular implants.
While this large, nonselective analysis is the first to adjust for numerous characteristics collected in the registry, residual confounding cannot be rule out.

Conclusions
Prosthesis revision is influenced by the prosthesis materials used in the primary procedure with the lowest risk for implants with delta ceramic or oxidised zirconium head and an HCLPE liner/cup. Further work is required to determine the association of implant bearing materials with the risk of rehospitalisation, re-operation other than revision, mortality, and the cost-effectiveness of these materials.
Neutralizing antibodies and safety of a COVID-19 vaccine against SARS-CoV-2 wild-type and Omicron variants in solid cancer patients
Authors: Chewaskulyong Busyamas , Satjaritanun Pattarapong , Ketpueak Thanika , Suksombooncharoen Thatthan , Charoentum Chaiyut , Nuchpong Nuttaphoom , Tantraworasin Apichat 
Published: November 2024

Objective
The aim of this study was to assess the seroconversion rate and percent inhibition of neutralizing antibodies against the wild-type and Omicron variants of SARS-CoV-2 in patients with solid cancer who received two COVID-19 vaccine doses by comparing chemotherapy and nonchemotherapy groups.

Methods
This prospective cohort study enrolled 115 cancer patients from Maharaj Nakorn Chiang Mai Hospital, Sriphat Medical Center, Faculty of Medicine, Chiang Mai University, and Chiang Mai Klaimor Hospital, Chiang Mai, Thailand, between August 2021 and February 2022, with data from 91 patients who received two COVID-19 vaccine doses analyzed. Participants received vaccines as part of their personal vaccination programs, including various mRNA and non-mRNA vaccine combinations. Blood samples were collected at baseline, on day 28, and at 6 months post-second dose to assess neutralizing antibodies. The primary outcome was the seroconversion rate against the wild-type and Omicron variants on day 28. Secondary outcomes included seroconversion at 6 months, factors associated with seroconversion, and safety.

Results
Among the participants, 45% were receiving chemotherapy. On day 28, seroconversion rates were 77% and 62% for the wild-type and Omicron variants, respectively. Chemotherapy did not significantly affect seroconversion rates (p = 0.789 for wild type, p = 0.597 for Omicron). The vaccine type administered was positively correlated with seroconversion, with an adjusted odds ratio (95% confidence interval) of 25.86 (1.39–478.06) for the wild type and 17.38 (3.65–82.66) for the Omicron variant with the primary heterologous vaccine regimen. Grades 1 and 2 adverse events were observed in 34.0% and 19.7% of participants, respectively.

Conclusions
Despite the lower seroconversion rate against the Omicron variant, no significant difference was observed between the chemotherapy and nonchemotherapy groups. COVID-19 vaccinations demonstrated good tolerability in this cohort. These findings highlight the importance of vaccine safety and immunogenicity in cancer patients and can inform tailored vaccination strategies for this vulnerable population.
The impact of the COVID-19 pandemic on stress and coping in parents of children with Autism Spectrum Disorder
Authors: Knedlíková Lenka , Dědková Lenka , Kolář Senad , Česká Katarína , Vyhnalová Martina , Stroupková Lucie , Pejčochová Jana , Pavel Theiner , Lacko David , Horák Ondřej , Ošlejšková Hana , Danhofer Pavlína 
Published: November 2024

Introduction
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impairments in communication, social interaction, and repetitive behavior. The declaration of the COVID-19 pandemic in March 2020 resulted in significant changes in daily life due to restrictive measures. This period posed particular challenges for families with children living with autism, given the limitations in medical care and social services.

Objective
This study aimed to understand how families with autistic children perceive stress during the pandemic and the coping strategies employed in unexpected situations.

Method
A total of 44 families with children with ASD and 300 control families, including 44 control families in a matched subsample, were included in the study. To assess stress and parental coping with COVID-19-related stress, the Responses to Stress Questionnaire (Adult Self-Report RSQ–COVID-19) was utilized.

Results
Caregivers of autistic children experienced significantly higher stress levels (p = .027, d = 0.479) during the pandemic, with notable stressors such as limited access to medical care and challenges associated with remote work. Despite expectations, coping strategy differences were not statistically significant.

Conclusion
Families and supporters of children with autism naturally encounter various experiences and challenges stemming from their additional needs. Our study’s results highlight an accentuation of stress during challenging situations. As these situations may recur in the future, there is a need to design and implement support plans for these families, appropriate intervention programs, and preparations for the utilization of telemedicine tools.
Insulin level, glycemia, insulin resistance and β-cell function in relation to the lifestyle of Arctic indigenous people. Are there conditions for diabetes and which type?
Authors: Strelkova A. V. , Bichkaeva F. A. , Vlasova O. S. , Nesterova E. V. , Shengof B. A. , Gretskaya T. B. 
Published: November 2024

BACKGROUND: Modern studies suggest that lifestyle changes of the indigenous Arctic residents lead to the loss of the “adaptive polar type of metabolism”, which is characterized by the intensification of protein metabolism, optimization of lipid metabolism, and minimization of carbohydrate metabolism at low insulin concentrations. How to survive the era of change?AIM: To assess insulinemia, glycemia, β-cell secretory activity, and insulin sensitivity in Arctic indigenous people in relation to their lifestyle.MATERIALS AND METHODS: A cross-sectional study of a population of indigenous Arctic residents (Nenets, Komi) aged from 22 to 60 years was conducted. Insulin levels were studied in blood serum using ELISA, and glucose levels using the spectrophotometric method. Insulin resistance (HOMA-IR) and β-cell function (HOMA1-%β) indices were calculated.RESULTS: 397 people were examined; 89 (22%) of them were nomadic people (NP) and 44 (49%) were male. Another 308 (78%) were sedentary people (SP), and 69 (22%) were male. The insulin level was significantly lower in NP (6.0 [3.5–11.8] µU/ml) compared to SP (8.3 [4.6–13.1] µU/ml), p=0.006. There was no difference in glycemia (4.6 [4.2–5.0] in NP and 4.6 [4.1–5.2] in SP) between lifestyles.The HOMA-IR was significantly lower in NP (1.3 [0.7–2.4]) than in SP (1.8 [0.95–2.8]), p=0.013. IR-HOMA >2 units was 1.8 times more frequent in the SP than in NP, with adjusted for sex, age, and BMI OR=0.56; 95% CI: 0.33–0.96, p=0.034. The median HOMA1-%β was 128 [67–241] % in NP and 144 [93–236]% in SP with no significant differences between groups. The proportion of individuals with HOMA1-%β <48.9 was 17% in NP versus 5% in SP, p<0.001. The adjusted odds of having HOMA1-%β <48.9 in NP are 3.5 times higher than in SP; 95% CI: 1.56–7.92, p=0.002. Fifty-six cases of glycemia ≥5.6 mmol/l were identified: 13.5% in NP and 14.3% in SP. The ratio IR-HOMA >2/ HOMA1-%β <48.9/BMI was 1.8 units/45%/25.2 kg/m2 in NP and 3.0 units/88%/29.6 kg/m2 in SP.CONCLUSION: Maintaining a nomadic lifestyle helps keep lower insulin concentrations; at the same time, glycemic levels in the groups were similar. In the NP group, there was a high proportion of individuals with low β-cell secretory activity, predominantly men; in the SP group, more individuals were insulin-resistant. Analysis of cases of glycemia ≥5.6 mmol/l confirmed, that hyperglycemia in a nomadic lifestyle was associated with β-cell hypofunction and the absence of obesity; on the contrary, in a sedentary lifestyle, it was associated with increased insulin resistance and obesity.
Mediathek Zeitgeschichte online – Nutzung digitaler Sicherungskopien audiovisueller Medien
Authors: Drews Marc , Stumpf Markus 
Published: November 2024

Zusammenfassung
In der Mediathek Zeitgeschichte online wird als Ergebnis eines Projektes ein Teilbestand der an der Fachbereichsbibliothek Zeitgeschichte der Universitätsbibliothek Wien vorhandenen audiovisuellen Medien unter Beachtung der österreichischen urheberrechtlichen Voraussetzungen in Form digitaler Sicherungskopien zur Nutzung bereitgestellt. In diesem Beitrag wird über die Umsetzung berichtet und die Mediathek Zeitgeschichte online vorgestellt.
Falso valor de HbA1c debido a la variante inusual hemoglobina Petie Salpetriere coheredada con talasemia alfa
Authors: Lepe Balsalobre Esperanza , Varo Sánchez Gema María , Rico Rodríguez Marta , Fuentes Cantero Sandra 
Published: November 2024

Resumen

Objetivos
Describir la variante de hemoglobina que interfiere en el análisis de HbA1c mediante HPLC de intercambio catiónico.

Caso clínico
Paciente de 78 años que acude a consulta de Medicina Interna para una revisión rutinaria, donde se incluye la determinación de HbA1c para la detección de diabetes. El paciente presenta como antecedentes hipertensión y dislipidemia sin presentar síntomas previos sugestivos de diabetes como hiperglucemia, pérdida de peso, polidipsia, poliuria o cansancio. La prueba de detección de la diabetes se realizó mediante determinación de la HbA1c con una columna de HPLC de intercambio catiónico y un analizador de inmunoensayo en el lugar de la asistencia (point of care). En la prueba rutinaria de detección de hemoglobinopatías se incluyó un hemograma completo, así como la determinación de HbF y HbA2 mediante HPLC de intercambio catiónico y electroforesis capilar (EC). La caracterización de variantes se realizó mediante secuenciación de ADN. Los resultados de HbA1c obtenidos fueron discordantes, la técnica HPLC de intercambio catiónico mostró una elevación de HbA1c de 52 mmol/mol, y el inmunoensayo mostró un nivel normal de 34 mmol/mol. La forma anormal del pico de HbA1c en el cromatograma motivó la realización de la prueba de detección de hemoglobinopatías para investigar la posible interferencia de variantes. Así, se realizó un análisis del gen de la globina, cuyos resultados revelaron la presencia de una variante de hemoglobina llamada “Hb Petie Salpetriere”. Esta variante surge de una sustitución Val→Phe resultante de una mutación de c.103G>T del gen de la beta-globina [BETA34 (B16) Val>Phe; HBB:c.103G>T]

Conclusiones
Se trata del primer caso de detección de la variante Hb Petie Salpetriere en un paciente español. Los resultados obtenidos indican que la variante Hb Petie Salpetriere puede interferir en los resultados de los análisis de HbA1c realizados mediante HPLC de intercambio iónico, no ocurriendo lo mismo con el método de inmunoensayo de aglutinación de látex. Únicamente el HPLC de intercambio iónico reveló la presencia de la variante de la Hb en este caso, lo que indica que se puede detectar una posible variante mediante una revisión meticulosa del cromatograma.