bluuebunny/crossref_metadata_2025_split huggingface dataset:
Historical Background
Authors: Newell H. Perry 
Published: June 2018

In view of a widespread belief1 that the mounds lying southwest of Alto, Texas, mark the site of an historic Neches village and the second location of the mission San Francisco de los Tejas, and since the archaeological evidence denies such an identification, it is necessary to review the early history of this region, pointing out certain discrepancies in the literature.The Neches was one of nine main trihes forming the Hasinai Confederation. Detailed accounts of their names, approximate locations, and political structure have been published by Bolton, Swanton, and others. Numerous names, with variations in spelling, have been given to this group of tribes. The French called them Cenis; the Spaniards, Hasinai or Tejas. These names were usually applied to the confederacy as a whole, but occasionally to a specific tribe or village. It is sufficient here to mention only two: the Nabedache, the most southwesterly group, among whom the first East Texas mission was established in 1690; and the Neches, who lived just across a river (presumably the Neches River) from them.
Description of Resident (Alto Focus) Pottery
Authors: Krieger Alex D. 
Published: June 2018

The various potteries supposedly made at the Davis site are described below, as (1) types, and (2) descriptive groups of uncertain typological affiliation. The statistics cited are taken from Tables 3-11 and the summaries in Tables 13-14.Descriptions of each major type have been made in the approved outline form of the Southeastern Archaeological Conference and are on file in the Anthropology Department of the University of Texas. They are not published here because I regard the pottery typology of this site, and the whole lower Mississippi region in general, as still in a state of experimentation. There may be many changes before we can be satisfied with the full ranges of variation (especially local variations) in many present types; there may be considerable shifting in the composition of known types, in conferences for that purpose or by other means, And, no matter how good and complete the formal outline descriptions are in any area, one cannot positively identify pottery types with them.
Collective quality improvement in the paediatric cardiology acute care unit: establishment of the Pediatric Acute Care Cardiology Collaborative (PAC3)
Authors: Kipps Alaina K. , Cassidy Steven C. , Strohacker Courtney M. , Graupe Margaret , Bates Katherine E. , McLellan Mary C. , Harahsheh Ashraf S. , Hanke Samuel P. , Tanel Ronn E. , Schachtner Susan K. , Gaies Michael , Madsen Nicolas 
Published: June 2018

AbstractCollaborative quality improvement and learning networks have amended healthcare quality and value across specialities. Motivated by these successes, the Pediatric Acute Care Cardiology Collaborative (PAC3) was founded in late 2014 with an emphasis on improving outcomes of paediatric cardiology patients within cardiac acute care units; acute care encompasses all hospital-based inpatient non-intensive care. PAC3aims to deliver higher quality and greater value care by facilitating the sharing of ideas and building alignment among its member institutions. These aims are intentionally aligned with the work of other national clinical collaborations, registries, and parent advocacy organisations. The mission and early work of PAC3is exemplified by the formal partnership with the Pediatric Cardiac Critical Care Consortium (PC4), as well as the creation of a clinical registry, which links with the PC4registry to track practices and outcomes across the entire inpatient encounter from admission to discharge. Capturing the full inpatient experience allows detection of outcome differences related to variation in care delivered outside the cardiac ICU and development of benchmarks for cardiac acute care. We aspire to improve patient outcomes such as morbidity, hospital length of stay, and re-admission rates, while working to advance patient and family satisfaction. We will use quality improvement methodologies consistent with the Model for Improvement to achieve these aims. Membership currently includes 36 centres across North America, out of which 26 are also members of PC4. In this report, we describe the development of PAC3, including the philosophical, organisational, and infrastructural elements that will enable a paediatric acute care cardiology learning network.
Mid-term follow-up study of neonatal isolated aberrant right subclavian artery
Authors: Jan Sheng-Ling , Lin Ming-Chih , Chan Sheng-Ching 
Published: June 2018

AbstractBackgroundAberrant right subclavian artery is the most common congenital aortic arch anomaly. There are a few reports concerning the clinical manifestations and follow-up of this CHD detected by echocardiographic screening.MethodsA total of 1737 full-term neonates, with a male-to-female ratio of 900:837, received echocardiographic screening. Neonates with or without isolated aberrant right subclavian artery were studied during infancy.ResultsAmong the 1737 cases, a total of 15 (0.86%) female-predominant neonates, with a male-to-female ratio of 6:9, had isolated aberrant right subclavian artery. They were compared with 20 age- and gender-matched normal neonates. There were no significant differences in maternal age, gestational age, or para gravity between the two groups, except for birth size (birth length- and weight-for-age percentiles, p = 0.006 and 0.045, respectively), which was smaller in the aberrant right subclavian artery group. Although there were no significant differences in developmental history, gastrointestinal, or respiratory symptoms, neonates with aberrant right subclavian artery had a higher incidence of mild developmental delay and feeding difficulty than normal infants (21 versus 0%, p = 0.061; 36 versus 20%, p = 0.264, respectively). The growth rates of body length and weight during infancy were not significantly different between the two groups.ConclusionsEchocardiography can be applied as a first-line investigation in the diagnostic work-up for aberrant right subclavian artery. Neonates with aberrant right subclavian artery had a smaller size at birth, although growth rates were not significantly different from those of normal infants. This study does not support an active surgical policy for asymptomatic infants with isolated aberrant right subclavian artery. A larger study and longer follow-up of affected infants is recommended.
A 1 to 32 GHz broadband multi-octave receiver for monolithic integrated vector network analyzers in SiGe technology
Authors: Dietz Marco , Bauch Andreas , Aufinger Klaus , Weigel Robert , Hagelauer Amelie 
Published: June 2018

AbstractA multi-octave receiver chain is presented for the use in a monolithic integrated vector network analyzer. The receiver exhibits a very wide frequency range of 1–32 GHz, where the gain meets the 3 dB-criterion. The differential receiver consists of an ultra-wideband low noise amplifier, an active mixer and an output buffer and exhibits a maximum conversion gain (CG) of 16.6 dB. The main design goal is a very flat CG over five octaves, which eases calibration of the monolithic integrated vector network analyzer. To realize variable gain functionality, without losing much input matching, an extended gain control circuit with additional feedback branch is shown. For the maximum gain level, a matching better than −10 dB is achieved between 1–28 GHz, and up to 30.5 GHz the matching is better than −8.4 dB. For both, the input matching and the gain of the LNA, the influence of the fabrication tolerances are investigated. A second gain control is implemented to improve isolation. The measured isolations between RF-to-LO and LO-to-RF are better than 30 dB and 60 dB, respectively. The LO-to-IF isolation is better than 35 dB. The noise figure of the broadband receiver is between 4.6 and 5.8 dB for 4–32 GHz and the output referred 1-dB-compression-point varies from 0.1 to 4.3 dBm from 2–32 GHz. The receiver draws a current of max. 66 mA at 3.3 V.
Erfassung des Lesevolumens in Large-Scale Studien
Authors: Locher Franziska M. , Pfost Maximilian 
Published: June 2018

Zusammenfassung. In diesem Beitrag werden 2 Möglichkeiten der Erfassung des Lesevolumens, wie sie in Large-Scale-Studien meist verwendet werden, verglichen – zum einen ein differenziertes textsortenspezifisches Urteil und zum anderen ein häufig angewendetes Globalurteil zur Einschätzung des Lesevolumens. Zum Vergleich der beiden Urteile liegen Daten des Nationalen Bildungspanels (NEPS) mit einer Stichprobe von N = 5 475 Schülerinnen und Schülern der 5. Klassenstufe und N = 16 425 Schülerinnen und Schülern der 9. Klassenstufe sowie eine Stichprobe aus PISA 2009 von N = 4 979 Schülerinnen und Schülern im Alter von 15 Jahren vor. Insgesamt zeigt sich, dass im NEPS (insbesondere in Klassenstufe 5) das Globalurteil das verlässlichere Instrument darstellt. Für die textsortenspezifischen Urteile zeigen sich u. a. deutliche Bodeneffekte und nur geringe Zusammenhänge mit den Kriteriumsmaßen Lesefreude und Lesekompetenz. Im Vergleich der beiden textsortenspezifischen Urteile in NEPS und PISA zeigt sich ein Vorteil für die in PISA verwendeten Items. Es werden Empfehlungen für den Umgang mit den NEPS-Daten aus den entsprechenden Scientific-Use-Files abgeleitet.
Normierung des SF-12 Version 2.0 zur Messung der gesundheitsbezogenen Lebensqualität in einer deutschen bevölkerungsrepräsentativen Stichprobe
Authors: Wirtz Markus Antonius , Morfeld Matthias , Glaesmer Heide , Brähler Elmar 
Published: June 2018

Zusammenfassung. Der Short-Form-Health Survey (SF-12) ist ein Screeninginstrument zur Erfassung der gesundheitsbezogenen Lebensqualität. Der Körperliche Skalenwert repräsentiert Allgemeine Gesundheitswahrnehmung, Körperliche Funktionsfähigkeit und Rollenfunktion sowie Schmerzen. Der Psychische Skalenwert bildet Emotionale Rollenfunktion, Psychisches Wohlbefinden, Negativen Affekt und Soziale Funktionsfähigkeit ab. Alternativ kann die Emotionale Rollenfunktion getrennt ermittelt werden. Die Daten entstammen einer schriftlichen Befragung einer für Deutschland repräsentativen Normstichprobe von N = 2 524 Personen. Der Körperliche Skalenwert kann mit R2 = .305 besser prädiziert werden als die Skalenwerte des psychischen Bereichs (R2 = .094 – .110). Das Alter determiniert den höchsten Varianzanteil. Zudem sind Geschlecht, Einkommen, Familienstand und Beruf prädiktiv. Die Normdaten werden für die Gesamtstichprobe sowie getrennt für Geschlechts- und Altersgruppen berichtet. Erwartungsgemäß treten in der nicht-klinischen Stichprobe Deckeneffekte am positiven Pol der Skalen auf. Einschränkungen der gesundheitsbezogenen Lebensqualität werden differenziert abgebildet.
„Emotionale Intelligenz“ mit einem Fragebogen messen?
Authors: Amrhein Annelie , Breuker Julia J. , Rost Detlef H. 
Published: June 2018

Zusammenfassung. Die faktorielle Validität des Trait Emotional Intelligence Questionnaire – Adolescent Short Form (TEIQue-ASF) und der Beitrag der damit erfassten „Emotionalen Intelligenz“ (EI) zur Aufklärung von Schulerfolg wurden an N = 711 deutschen Schülerinnen und Schüler der 6., 7. und 8. Jahrgangsstufe überprüft. Explorative und konfirmatorische Faktorenanalysen ergaben, dass weder das zugrundeliegende theoretische Vier-Faktoren-Modell noch der für die Kurzform vorgesehene globale EI-Wert mit den Daten vereinbar waren. Stattdessen resultierte eine dreifaktorielle Lösung mit 9 Items, welche auch im Vergleich zu Alternativmodellen am besten auf die Daten passte. Jenseits von verbaler Intelligenz und klassischen Persönlichkeitsvariablen lieferte der TEIQue-ASF keinen bedeutsamen Beitrag zur Varianzaufklärung der Schulleistung (Notendurchschnitt). Die Nützlichkeit des TEIQue-ASF wird diskutiert, weitere Validitätsüberprüfungen werden dringend empfohlen.
Inversion of Structural Geology Data for Fold Geometry
Authors: Grose L. , Laurent G. , Aillères L. , Armit R. , Jessell M. , Cousin‐Dechenaud T. 
Published: June 2018

AbstractRecent developments in structural modeling techniques have dramatically increased the capability to incorporate fold‐related data into the modeling workflow. However, these techniques are lacking a mathematical framework for properly addressing structural uncertainties. Previous studies investigating structural uncertainties have focused on the sensitivity of the interpolator to perturbing the input data. These approaches do not incorporate conceptual uncertainty about the geological structures and interpolation process to the overall uncertainty estimate. In this work, we frame structural modeling as an inverse problem and use a Bayesian framework to reconcile structural parameters and data uncertainties. Bayesian inference is applied for determining the posterior probability distribution of fold parameters given a set of structural observations and prior distributions based on general geological knowledge and regional observations. This approach allows for an inversion of structural geology data, where each realization can differ in the structural description of the fold geometries, instead of finding only a single best fit solution. We show that analyzing the variability between the resulting models highlights uncertainties associated with the geometry of regional structures. These areas can be used to target where additional data would be most beneficial for improving the model quality and efficiently reducing structural uncertainty.
Seafloor Topography Estimation From Gravity Gradients Using Simulated Annealing
Authors: Yang Junjun , Jekeli Christopher , Liu Lintao 
Published: June 2018

AbstractInferring seafloor topography from gravity anomaly currently is the dominant method to obtain a global view of the oceans. Standard techniques rely on an approximate, linear relationship between topography and gravity, which is valid only if the local topography is smooth compared with the regional topography, so the estimation accuracy in the very rugged areas is low. Current methods can be improved by removing the linear approximation and estimating the topography through simulated annealing and by using gravity gradiometry that is more sensitive to topography at short wavelengths than the gravity anomaly. Simulated annealing is a global optimization technique that can process nonlinear inverse problems. It is developed to estimate the seafloor depths by minimizing the difference between the observed and forward‐computed vertical gravity gradients. The method is tested on altimetry‐derived gravity gradients in a 2∘×2∘ area of rugged seafloor topography in the West Pacific Ocean and results in estimates with a root‐mean‐square error of ±236 m. Compared to estimates from an existing model obtained by standard techniques this represents an accuracy improvement of 22%.
Spatial Distribution of Channel and Floodplain Large Wood in Forested River Corridors of the Northern Rockies
Authors: Wohl Ellen , Scott Daniel N. , Lininger Katherine B. 
Published: June 2018

AbstractPlanform geometry, spatial heterogeneity, and large wood abundance and distribution were characterized using combined remote imagery and field surveys along lengths of 20–28 km in four river corridors (channels and floodplains) in northwestern Montana. Study sites included four planform geometries: meandering, straight, braided, and multichannel. Planform spatial heterogeneity of channels and floodplains, such as proportion of the active channel in bars, sinuosity, braiding index, and the number of active channels, differs in relation to channel planform type. Braided and multichannel rivers have significantly greater spatial heterogeneity of channels and floodplains and store significantly greater volumes of wood in the channel. Wood is preferentially stored in jams, and jams are preferentially stored in shallow areas of the active channel (midchannel bars, inner bends, and secondary channels) and in abandoned channels on the floodplain. We interpret these results using a conceptual model in which boundary conditions create sufficient valley‐bottom width for the development of planform spatial heterogeneity, which then promotes storage of large wood. The results of this study can inform management that protects or restores spatial heterogeneity.
Mechanically robust stretchable organic optoelectronic devices built using a simple and universal stencil-pattern transferring technology
Authors: Yin Da , Jiang Nai-Rong , Liu Yue-Feng , Zhang Xu-Lin , Li Ai-Wu , Feng Jing , Sun Hong-Bo 
Published: June 2018

AbstractStretchable electronic and optoelectronic devices based on controllable ordered buckling structures exhibit superior mechanical stability by retaining their buckling profile without distortion in repeated stretch-release cycles. However, a simple and universal technology to introduce ordered buckling structures into stretchable devices remains a real challenge. Here, a simple and general stencil-pattern transferring technology was applied to stretchable organic light-emitting devices (SOLEDs) and polymer solar cells (SPSCs) to realize an ordered buckling profile. To the best of our knowledge, both the SOLEDs and SPSCs with periodic buckles exhibited the highest mechanical robustness by operating with small performance variations after 20,000 and 12,000 stretch-release cycles between 0% and 20% tensile strain, respectively. Notably, in this work, periodic-buckled structures were introduced into SPSCs for the first time, with the number of stretch-release cycles for the SPSCs improved by two orders of magnitude compared to that for previously reported random-buckled stretchable organic solar cells. The simple method used in this work provides a universal solution for low-cost and high-performance stretchable electronic and optoelectronic devices and promotes the commercial development of stretchable devices in wearable electronics.
High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2
Authors: Cappella Marisa , Perfetti Alessandra , Cardinali Beatrice , Garcia-Manteiga Jose Manuel , Carrara Matteo , Provenzano Claudia , Fuschi Paola , Cardani Rosanna , Renna Laura Valentina , Meola Giovanni , Falcone Germana , Martelli Fabio 
Published: June 2018

AbstractMyotonic dystrophy type 1 (DM1) is a multi-systemic disorder caused by abnormally expanded stretches of CTG DNA triplets in theDMPKgene, leading to mutated-transcript RNA-toxicity. MicroRNAs (miRNAs) are short non-coding RNAs that, after maturation, are loaded onto the RISC effector complex that destabilizes target mRNAs and represses their translation. In DM1 muscle biopsies not only the expression, but also the intracellular localization of specific miRNAs is disrupted, leading to the dysregulation of the relevant mRNA targets. To investigate the functional alterations of the miRNA/target interactions in DM1, we analyzed by RNA-sequencing the RISC-associated RNAs in skeletal muscle biopsies derived from DM1 patients and matched controls. The mRNAs found deregulated in DM1 biopsies were involved in pathways and functions relevant for the disease, such as energetic metabolism, calcium signaling, muscle contraction and p53-dependent apoptosis. Bioinformatic analysis of the miRNA/mRNA interactions based on the RISC enrichment profiles, identified 24 miRNA/mRNA correlations. Following validation in 21 independent samples, we focused on the couple miR-29c/ASB2 because of the role of miR-29c in fibrosis (a feature of late-stage DM1 patients) and of ASB2 in the regulation of muscle mass. Luciferase reporter assay confirmed the direct interaction between miR-29c and ASB2. Moreover, decreased miR-29c and increased ASB2 levels were verified also in immortalized myogenic cells and primary fibroblasts, derived from biopsies of DM1 patients and controls. CRISPR/Cas9-mediated deletion of CTG expansions rescued normal miR-29c and ASB2 levels, indicating a direct link between the mutant repeats and the miRNA/target expression. In conclusion, functionally relevant miRNA/mRNA interactions were identified in skeletal muscles of DM1 patients, highlighting the dysfunction of miR-29c and ASB2.
Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies
Authors: Lewis Alexander C. , Wallington-Beddoe Craig T. , Powell Jason A. , Pitson Stuart M. 
Published: June 2018

AbstractConventional chemotherapy-based drug combinations have, until recently, been the backbone of most therapeutic strategies for cancer. In a time of emerging rationale drug development, targeted therapies are beginning to be added to traditional chemotherapeutics to synergistically enhance clinical responses. Of note, the importance of pro-apoptotic ceramide in mediating the anti-cancer effects of these therapies is becoming more apparent. Furthermore, reduced cellular ceramide in favour of pro-survival sphingolipids correlates with tumorigenesis and most importantly, drug resistance. Thus, agents that manipulate sphingolipid metabolism have been explored as potential anti-cancer agents and have recently demonstrated exciting potential to augment the efficacy of anti-cancer therapeutics. This review examines the biology underpinning these observations and the potential use of sphingolipid manipulating agents in the context of existing and emerging therapies for haematological malignancies.
Co-occurrence of frameshift mutations in SMAD6 and TCF12 in a child with complex craniosynostosis
Authors: Timberlake Andrew T. , Wu Robin , Nelson-Williams Carol , Furey Charuta G. , Hildebrand Kristi I. , Elton Scott W. , Wood Jeyhan S. , Persing John A. , Lifton Richard P. 
Published: June 2018

AbstractNon-syndromic craniosynostosis (CS) affects 1 in 2350 live births. Recent studies have shown that a significant fraction of cases are caused by de novo or rare transmitted mutations that promote premature osteoblast differentiation in cranial sutures. Rare heterozygous loss-of-function (LOF) mutations in SMAD6 and TCF12 are highly enriched in patients with non-syndromic sagittal and coronal CS, respectively. Interestingly, both mutations show striking incomplete penetrance, suggesting a role for modifying alleles; in the case of SMAD6, a common variant near BMP2 drastically increases penetrance of sagittal CS. Here, we report a proband presenting with both sagittal and coronal craniosynostosis with the highly unusual recurrence of CS within two months of initial surgery, requiring a second operation to re-establish suture patency at six months of age. Exome sequencing revealed a rare transmitted frameshift mutation in SMAD6 (p. 152 fs*27) inherited from an unaffected parent, absence of the common BMP2 risk variant, and a de novo frameshift mutation in TCF12 (p.E548fs*14). SMAD6 and TCF12 independently inhibit transcriptional targets of BMP signaling. The findings are consistent with epistasis of these mutations, increasing penetrance and severity of CS in this proband. They also add to the list of composite phenotypes resulting from two Mendelian mutations, and support the utility of exome sequencing in atypical CS cases.