bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pan-cancer microsatellite instability to predict for presence of Lynch syndrome.
Authors: Latham Schwark Alicia , Srinivasan Preethi , Kemel Yelena , Shia Jinru , Bandlamudi Chaitanya , Mandelker Diana , Dubard-Gault Marianne , Tran Christina , Middha Sumit , Hechtman Jaclyn Frances , Penson Alexander , Varghese Anna M. , Zhang Liying , Robson Mark E. , Solit David B. , Diaz Luis A. , Taylor Barry S. , Offit Kenneth , Berger Michael F. , Stadler Zsofia Kinga 
Published: June 2018

LBA1509 Background: The success of immunotherapy in microsatellite unstable (MSI-H) and/or DNA mismatch repair deficient (MMR-D) tumors has resulted in routine MSI-H/MMR-D testing in advanced solid tumors. Unlike colorectal (CRC) and endometrial cancer (EC), where this has long been undertaken, the characterization of Lynch syndrome (LS) across heterogeneous MSI-H/MMR-D tumors is unknown. Methods: Through a targeted NGS panel, MSI status was determined via MSIsensor. Scores of < 3, ≥3 to < 10, or ≥10 designated Microsatellite stable (MSS), MSI-Indeterminate (MSI-I) or MSI-H status, respectively. Germline mutations were assessed in MLH1, MSH2, MSH6, PMS2, EPCAM. Immunohistochemical staining (IHC) for MMR-D and tumor signatures in LS patients were assessed. Clinical variables were correlated with MSI and compared via Chi square or T-test. Results: Of 15,045 tumors spanning > 50 cancers , 93.2% were MSS, 4.6% MSI-I, and 2.2% MSI-H. Germline mutations were identified in 0.3% (37/14,020), 1.9% (13/699), and 16.3% (53/326) in the MSS, MSI-I, and MSI-H groups, respectively (p-value < 0.001). 25% of 1,025 MSI-H/MSI-I tumors were CRC/EC, but 50% (33/66) of LS patients had MSI-H/MSI-I tumors less commonly or not previously associated with LS (mesothelioma, sarcoma, adrenocortical, melanoma, ovarian germ cell). LS pts with MSI-H/MSI-I non-CRC/EC tumors only met testing criteria in 63.6% of cases, had lower MSIsensor scores, and were more likely to be MSI-I (MSI-I: non-CRC/EC, 30.3% (10/33) vs CRC/EC 9.1% (3/33); p-value = 0.03). IHC was completed in 86.4% (57/66) of LS MSI-H/MSI-I tumors, with 98.3% MMR-D-concordance. Of LS pts with MSS tumors, 78% had MSH6/PMS2 mutations, but 71% of LS pts with MSI-H/MSI-I tumors had MLH1/MSH2/EPCAM mutations(p-value < 0.001). 89% (33/37) of MSS tumors of LS pts had non-MMR-D signatures. Conclusions: MSI-H/MMR-D is predictive of LS across tumor types and suggests a more heterogeneous spectrum of LS-associated cancers than previously appreciated. Nearly 40% of LS pts with MSI-H/MMR-D non-CRC/EC tumors did not meet clinical criteria for genetic testing, suggesting that MSI-H/MMR-D tumors, regardless of cancer type or family history, should prompt germline testing for the evaluation of LS.
Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer (PREOPANC-1): A randomized, controlled, multicenter phase III trial.
Authors: Van Tienhoven Geertjan , Versteijne Eva , Suker Mustafa , Groothuis Karin B.C. , Busch Olivier R. , Bonsing Bert A. , de Hingh Ignace H.J.T. , Festen Sebastiaan , Patijn Gijs A. , de Vos-Geelen Judith , Zwinderman Aeilko H. , Punt Cornelis J. A. , van Eijck Casper H.J. ,   and all other investigators of the institutions participating in the trial on behalf of the Dutch Pancreatic Cancer Group
Published: June 2018

LBA4002 Background: Standard of care for patients with (borderline) resectable pancreatic adenocarcinoma is resection followed by adjuvant chemotherapy. Previous studies suggest a benefit of neoadjuvant treatment. We conducted a multicenter phase III randomized controlled trial to evaluate the effect of preoperative chemoradiotherapy. Methods: Patients with (borderline) resectable pancreatic cancer, pathologically confirmed, were randomized between immediate surgery (arm A) and preoperative chemoradiotherapy (arm B), both followed by adjuvant chemotherapy. The preoperative chemoradiotherapy consisted of 15 times of 2.4 Gray (Gy) combined with gemcitabine, 1,000 mg/m2 on days 1, 8 and 15, preceded and followed by a cycle of gemcitabine. Primary endpoint was overall survival (OS), secondary endpoints were (R0) resection rate, disease free survival (DFS), distant metastases free interval (DMFI), locoregional recurrence free interval (LRFI) and toxicity. Accrual was completed between April 23, 2013 and July 25, 2017. Results: In total, 246 patients were included in the intention-to-treat analysis (127 patients in arm A and 119 in arm B). Currently, 142 of the 176 needed events for the primary outcome are observed. OS was significantly better in arm B (median 13.5 vs. 17.1 months; HR 0.71; p = 0.047). This was also the case for R0 resection rate (31% vs. 65%, p = < 0.001), DFS (median 7.9 vs. 11.2 months; HR 0.67; p = 0.010), DMFI (median 10.2 vs 17.1 months; HR 0.63; p = 0.012) and LRFI (median 11.8 vs not reached; HR 0.47; p < 0.001). Resection rates were 72% (91/127) in arm A vs. 62% (74/119) in arm B (p = 0.15). No significant difference was observed in grade ≥ 3 adverse events between both groups (p = 0.17). A subgroup analysis of patients who actually underwent a resection was performed which showed a median OS of 16.8 and 29.9 months respectively (p < 0.001). Conclusion: Our preliminary data show that preoperative chemoradiotherapy significantly improves outcome in (borderline) resectable pancreatic cancer compared to immediate surgery. Updated results will be presented at the meeting. Clinical trial information: NTR3709.
Overall survival between African-American (AA) and Caucasian (C) men with metastatic castration-resistant prostate cancer (mCRPC).
Authors: Halabi Susan , Dutta Sandipan , Tangen Catherine M. , Rosenthal Mark , Petrylak Daniel Peter , Thompson Ian Murchie , Chi Kim N. , De Bono Johann S. , Fandi Abderrahim , Araujo John C. , Eisenberger Mario A. , Logothetis Christopher , Quinn David I. , Fizazi Karim , Higano Celestia S. , George Daniel J. , Morris Michael J. , Small Eric Jay , Tannock Ian , Kelly William Kevin 
Published: June 2018

LBA5005 Background: Reports have suggested that African-American (AA) men with metastatic castration-resistant prostate cancer (mCRPC) have shorter overall survival (OS) than Caucasian (C) men. Prior reports have been limited by small sample size. The primary goal of this analysis was to compare OS in AA men to Caucasian men treated with docetaxel/prednisone or a docetaxel/prednisone containing regimen. Methods: Individual patient data from 8,871 mCRPC men randomized on nine phase III trials to docetaxel/prednisone (DP) or a DP containing regimen were combined. Race used in the analysis was based on self-report. The primary endpoint is OS, defined as the time between randomization and death or date of last follow-up if patients were alive. The proportional hazards model was used to assess the prognostic importance of race (AA vs. C) adjusting for established risk factors that were common across the trials (age, PSA, performance status, alkaline phosphatase, hemoglobin, and sites of metastases). Results: Of 8,871 patients, 7,528 (85%) were C, 500 (6%) were AA, 424 were Asian (5%) and 419 (4%) had race unspecified. The last two groups were deleted from the analysis leaving 8,452 pts. Median age was 69 years and 94% had performance status 0-1. Median hemoglobin, PSA and alkaline phosphatase were 12.9 g/dL, 86 ng/mL and 139 U/L, respectively. Pattern of metastatic spread were: 72% bone disease with or without lymph nodes, 9% lung disease, 9% liver disease and 7% lymph nodes only. Median OS were 21.0 (95% CI = 19.4-22.5) vs. 21.2 months (95% CI = 20.8-21.7) in AAs and C, respectively. In multivariable analysis adjusting for established risk factors, the pooled hazard ratio (HR) for AAs vs. Caucasians was 0.81 (95% CI = 0.72-0.92, p-value = 0.001) in all patients. Similar results were observed in 4,172 of patients who were treated with DP. Conclusions: We observed a statistically significant increased OS in AA vs. C men with mCRPC who were eligible to be enrolled on these clinical trials. Further understanding the biological variation by race in men with mCRPC treated with DP is warranted.
Decision Support Tool Improves Real and Perceived Anesthesiology Resident Relief Equity
Authors: Bhutiani Monica , Jablonski Patrick M. , Ehrenfeld Jesse M. , McEvoy Matthew D. , Fowler Leslie C. , Wanderer Jonathan P. 
Published: June 2018

BACKGROUND:
The Accreditation Council of Graduate Medical Education requires monitoring of resident clinical and educational hours but does not require tracking daily work patterns or duty hour equity. Lack of such monitoring may allow for inequity that affects resident morale. No defined system for resident relief of weekday operating room (OR) clinical duties existed at our institution, leaving on-call residents to independently decide daily relief order. We developed an automated decision support tool (DST) to improve equitable decision making for clinical relief and assessed its impact on real and perceived relief equity.

METHODS:
The DST sent a daily e-mail to the senior resident responsible for relief decisions. It contained a prioritized relief list of noncall residents who worked in the OR beyond 5 pm the prior clinical day. We assessed actual relief equity using the number of times a resident worked in the OR past 5:30 pm on 2 consecutive weekdays as our outcome, adjusting for the mean number of open ORs each day between 5:00 pm and 6:59 pm in our main OR areas. We analyzed 14 months of data before implementation and 16 months of data after implementation. We assessed perceived relief equity before and after implementation using a questionnaire.

RESULTS:
After implementing the DST, the percentage of residents held 2 consecutive weekdays over the total of resident days worked decreased from 1.33% to 0.43%. The percentage of residents held beyond 5:30 pm on any given day decreased from 18.09% to 12.64%. Segmented regression analysis indicated that implementation of the DST was associated with a reduction in biweekly time series of residents kept late 2 days in a row, independent of the mean number of ORs in use. Surveyed residents reported the DST aided their ability to make equitable relief decisions (pre 60% versus post 94%; P = .0003). Eighty-five percent of residents strongly agreed that a prioritized relief list based on prior day work hours after 5 pm aided their decision making. After implementation, residents reported fewer instances of working past 5 pm within the past month (P < .005).

CONCLUSIONS:
A DST systematizing the relief process for anesthesiology residents was associated with a lower frequency of residents working beyond 5:30 pm in the OR on 2 consecutive days. The DST improved the perceived ability to make equitable relief decisions by on-call senior residents and residents being relieved. Success with this tool allows for broader applications in resident education, enabling enhanced monitoring of resident experiences and support for OR assignment decisions.
Desiring Blackness: A Queer Orientation to Marvel’sBlack Panther, 1998–2016
Authors: carrington andré 
Published: June 2018

AbstractThe socially symbolic figure of the superhero comes into close contact with vernacular intellectual critiques of race and modernity through the much-anticipated film adaptation of Marvel’s Black Panther comics. This article analyzes the implications for queer approaches to black popular cultural production of the knowledge practices that inspire Black Panther’s depiction of an African utopia. The intertexts involved include histories, travel writings, and other comics. Focusing on the divergent treatments by authors Christopher Priest (1998–2003) and Ta-Nehisi Coates (2016) of the title character’s black female comrades-in-arms, this reading interrogates how race consciousness and colonial legacies inform the discourses of desire operating within the text. The term desiring blackness describes an orientation to reading that defers to African Americanist and black diasporic considerations to ground the task of interpretation in conditions that elicit compromise among disparate lines of theoretical inquiry: queer phenomenology, decolonial epistemology, Afrofuturism, and queer of color critique.
Nancy and the Queer Adorable in the Serial Comics Form
Authors: Stark Jessica Q. 
Published: June 2018

Abstract
This essay presents in dialogue two renditions of the Nancy comics by original creator Ernie Bushmiller and the later poet and visual artist Joe Brainard. Arguing for a generative consideration of these seemingly disparate versions on a continuum, this comparison addresses the ongoing seriality of Nancy as offering a complex queer adorability that destabilizes modes of identification in the Nancy comics and beyond. Both Brainard’s and Bushmiller’s Nancy texts draw on the controlled miniature and the unwieldy additive catalog, which are characteristic of the long-running serial comics form. As queer texts that oscillate between popular iconographies, these iterations of Nancy provide resistance to expectations for normativity, narrative closure, static character performance, and bound space in relation to twentieth-century American collective identities.
The Normative Broken: Melinda Gebbie, Feminist Comix, and Child Sexuality Temporalities
Authors: Wanzo Rebecca 
Published: June 2018

AbstractLost Girls (2006) is a return to the themes explored by Melinda Gebbie and other underground feminist cartoonists in the 1970s and 1980s. The text, a collaboration between Gebbie and Alan Moore, should be read as reminiscent of feminist cartoonists who intentionally depicted the taboo or obscene in order to address sexual and gender inequalities. These comics suggest that the obscene can push against purity narratives attached to womanhood, narratives that potentially stigmatize all girls and women. Lost Girls keeps the taboos of children’s sexuality and incest central to the representation in order to reframe possibilities of women’s healthy sexual subjectivity. Injurious pasts and irreconcilable desires do not preclude joyous futures. Painful pasts enable the eponymous lost girls’ agency, creating the conditions that help them find homosocial and queer belonging with one another. The comic thus models the temporalities of surviving trauma. The feminist temporalities of survivorship here also model utopian futures that are homosocial, queer, often ecstatic, and resistant to normative scripts of what should give women comfort. Undergirded by a radical feminist perspective that sees injury as being embedded in many women’s experiences, the creation of community from the wound makes it normal to have been broken.
A Model of Two-Sided Costly Communication for Building New Product Category Demand
Authors: Lu Michelle Y. , Shin Jiwoong 
Published: June 2018

When a firm introduces a radical innovation, consumers are unaware of the product’s uses and benefits. Moreover, consumers are unsure of whether they even need the product. In this situation, we consider the role of marketing communication as generating consumers’ need recognition and thus market demand for a novel product. In particular, we model marketing communication as a two-sided process that involves both firms’ and consumers’ costly efforts to transmit and assimilate a novel product concept. When the marketing communication takes on a two-sided process, we study a firm’s different information disclosure strategies for its radical innovation. We find that sharing innovation, instead of extracting a higher rent by keeping the idea secret, can be optimal. A firm may benefit from the presence of a competitor and its communication effort. The innovator can share its innovation so that competitors can also benefit, which encourages rivals to enter the market. The presence of such competition guarantees a higher surplus for consumers, which can induce greater consumer effort in a two-sided communication process. Moreover, the increased consumer effort, in turn, prompts complementarity in the communication process and lessens the potential free-riding effect in communication between firms. Additionally, it encourages the rival firm to exert more effort, especially when the role of consumers becomes more important. Sharing innovation with a rival serves as a mechanism to induce more efforts in a two-sided communication process. The online appendix is available at https://doi.org/10.1287/mksc.2017.1071 .
Total hip arthroplasty in patients affected by poliomyelitis
Authors: DeDeugd C. M. , Perry K. I. , Trousdale W. H. , Taunton M. J. , Lewallen D. G. , Abdel M. P. 
Published: June 2018

Aims The aims of this study were to determine the clinical and radiographic outcomes, implant survivorship, and complications of patients with a history of poliomyelitis undergoing total hip arthroplasty (THA) in affected limbs and unaffected limbs of this same population. Patients and Methods A retrospective review identified 51 patients (27 male and 24 female, 59 hips) with a mean age of 66 years (38 to 88) and with the history of poliomyelitis who underwent THA for degenerative arthritis between 1970 and 2012. Immigrant status, clinical outcomes, radiographic results, implant survival, and complications were recorded. Results In all, 32 THAs (63%) were performed on an affected limb, while 27 (37%) were performed on an unaffected limb. The overall ten-year survivorship free from aseptic loosening, any revision, or any reoperation were 91% (95% CI 0.76 to 0.99), 91% (95% CI 0.64 to 0.97) and 87% (95% CI 0.61 to 0.95), respectively. There were no revisions for prosthetic joint infection. There were no significant differences in any of the above parameters if THA was on the affected or unaffected control limbs. Conclusion Patients with a history of poliomyelitis who undergo THA on the affected or unaffected limbs have similar results with overall survivorship and complication rates to those reported results in patients undergoing THA for osteoarthritis. At long-term follow-up, previous clinical concerns about increased hip instability due to post-polio abductor weakness were not observed. Cite this article: Bone Joint J 2018;100-B:733–9.
Switching the behaviour of consumers to circular products and services with particular reference to the appeal of green batteries: An econometric analysis of evidence from Thailand
Authors: Dokmai Bancha 
Published: June 2018

Abstract
Used and discarded primary batteries are a major source of toxic pollution. The substitution of green primary batteries for conventional non-green batteries is however contingent on consumers’ willingness to pay premium prices for green primary batteries. The aim of this article is to explore evidence as to whether the environmental concern of individuals can prompt them to pay premium prices for green primary batteries. An econometric model is used to investigate the determinants of consumers’ purchasing behaviour and their willingness to pay premium prices for green batteries. Data for the study were obtained through a survey of Thai consumers in July 2016, which elicited 213 responses. An Analysis of the survey data shows significant evidence of environmental concern among Thai consumers as a factor that bears on the willingness to pay premium prices for green battery products and services. Gender, age and product lifespan are also shown to influence preference for green battery products and services. Further findings include that Thai consumers would pay a premium of 29 per cent over the price of non-green conventional battery price to enhance their concern for the environment, but that they would make no distinction between eco-labelled green primary batteries the production and use of which corresponds the ‘cradle-to-grave’ business model; and green battery product services, which relate to the ‘closed loop’, circular economy business model.
Exploring factors influencing technology transfer capability: Constructing a model through grounded theory
Authors: Huynh Tai Thao 
Published: June 2018

Abstract
The purpose of this qualitative research is to explore a conceptualization of factors that influence technology transfer capability. It identifies what and how factors perceived by expert participants impact technology transfer. Data from in-depth semi-structured interviews with twenty participants, who are experts in the field of technology management from top food enterprises, were analysed using grounded theory methodology to categorize concepts and conceptualize a provisional model. NVivo software application was used for qualitative data analysis. The study results identify organizational, departmental and environmental factors that impact technology transfer capability. Seven main themes emerged relating to: (1) new technology identification, acquisition and implementation ability; (2) research and development (R&D) ability; and (3) external environment. The data also clearly illustrate how these factors work in the food industry context and provide a foundation for developing a theoretical framework. The article provides implications for the development of a more complete model of determinants of technology transfer capability for firm owners, policy-makers and technology managers to develop more sustainable strategies to boost firms’ technology transfer and enhance competitive advantage. This article fulfills an identified need to study technology transfer capability and fills a literature gap in technology management by a qualitative study of industry experts.
Implementation of cleaner production along with quality management tools
Authors: Cotrim Syntia Lemos , Filho Dante Alves Medeiros , Leal Gislaine Camila Lapasini , Galdamez Edwin Vladimir Cardoza 
Published: June 2018

Abstract
Industries use management models and tools to meet environmental standards, while maintaining economic growth at a sustainable level. There is a growing body of knowledge about the implementation of cleaner production methods; however, questions as to which tools to use in the collection and analysis of data about the production process, or how to prioritize actions for improvement of the production process, have not yet been adequately addressed. This article evaluates models in order to obtain a method that integrates the concept of cleaner production integrated method (CPIM) with quality management tools and techniques. Cleaner production methods alone are very vague and the application of its stages is far from clear. So the use of quality management tools would give the much required support for the implementation of cleaner production programmes. To evaluate this model, a case study is presented in an industry in the food sector. This research has enabled the analysis of the applicability of the method and its impact in reducing waste generation and consumption of natural resources. As a result, a 19 per cent reduction was obtained in total waste generation and 35 per cent reduction in waste generation in the main sector where the method was applied.
On the well-posedness of a multiscale mathematical model for Lithium-ion batteries
Authors: Díaz J. Ildefonso , Gómez-Castro David , Ramos Angel M. 
Published: June 2018

Abstract
We consider the mathematical treatment of a system of nonlinear partial differential equations based on a model, proposed in 1972 by J. Newman, in which the coupling between the Lithium concentration, the phase potentials and temperature in the electrodes and the electrolyte of a Lithium battery cell is considered. After introducing some functional spaces well-adapted to our framework, we obtain some rigorous results showing the well-posedness of the system, first for some short time and then, by considering some hypothesis on the nonlinearities, globally in time. As far as we know, this is the first result in the literature proving existence in time of the full Newman model, which follows previous results by the third author in 2016 regarding a simplified case.