bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liquid phase blending of metal-organic frameworks
Authors: Longley Louis , Collins Sean M. , Zhou Chao , Smales Glen J. , Norman Sarah E. , Brownbill Nick J. , Ashling Christopher W. , Chater Philip A. , Tovey Robert , Schönlieb Carola-Bibiane , Headen Thomas F. , Terrill Nicholas J. , Yue Yuanzheng , Smith Andrew J. , Blanc Frédéric , Keen David A. , Midgley Paul A. , Bennett Thomas D. 
Published: May 2018

AbstractThe liquid and glass states of metal–organic frameworks (MOFs) have recently become of interest due to the potential for liquid-phase separations and ion transport, alongside the fundamental nature of the latter as a new, fourth category of melt-quenched glass. Here we show that the MOF liquid state can be blended with another MOF component, resulting in a domain structured MOF glass with a single, tailorable glass transition. Intra-domain connectivity and short range order is confirmed by nuclear magnetic resonance spectroscopy and pair distribution function measurements. The interfacial binding between MOF domains in the glass state is evidenced by electron tomography, and the relationship between domain size and Tg investigated. Nanoindentation experiments are also performed to place this new class of MOF materials into context with organic blends and inorganic alloys.
RegenDbase: a comparative database of noncoding RNA regulation of tissue regeneration circuits across multiple taxa
Authors: King Benjamin L. , Rosenstein Michael C. , Smith Ashley M. , Dykeman Christina A. , Smith Grace A. , Yin Viravuth P. 
Published: May 2018

Abstract
Regeneration is an endogenous process of tissue repair that culminates in complete restoration of tissue and organ function. While regenerative capacity in mammals is limited to select tissues, lower vertebrates like zebrafish and salamanders are endowed with the capacity to regenerate entire limbs and most adult tissues, including heart muscle. Numerous profiling studies have been conducted using these research models in an effort to identify the genetic circuits that accompany tissue regeneration. Most of these studies, however, are confined to an individual injury model and/or research organism and focused primarily on protein encoding transcripts. Here we describe RegenDbase, a new database with the functionality to compare and contrast gene regulatory pathways within and across tissues and research models. RegenDbase combines pipelines that integrate analysis of noncoding RNAs in combination with protein encoding transcripts. We created RegenDbase with a newly generated comprehensive dataset for adult zebrafish heart regeneration combined with existing microarray and RNA-sequencing studies on multiple injured tissues. In this current release, we detail microRNA–mRNA regulatory circuits and the biological processes these interactions control during the early stages of heart regeneration. Moreover, we identify known and putative novel lncRNAs and identify their potential target genes based on proximity searches. We postulate that these candidate factors underscore robust regenerative capacity in lower vertebrates. RegenDbase provides a systems-level analysis of tissue regeneration genetic circuits across injury and animal models and addresses the growing need to understand how noncoding RNAs influence these changes in gene expression.
Longevity extension in Drosophila through gut-brain communication
Authors: Westfall Susan , Lomis Nikita , Prakash Satya 
Published: May 2018

AbstractAging and chronic disease development are multifactorial processes involving the cumulative effects of metabolic distress, inflammation, oxidative stress and mitochondrial dynamics. Recently, variations in the gut microbiota have been associated with age-related phenotypes and probiotics have shown promise in managing chronic disease progression. In this study, novel probiotic and synbiotic formulations are shown to combinatorially extend longevity in male Drosophila melanogaster through mechanisms of gut-brain-axis communication with implications in chronic disease management. Both the probiotic and synbiotic formulations rescued markers of metabolic stress by managing insulin resistance and energy regulatory pathways. Both formulations also ameliorated elevations in inflammation, oxidative stress and the loss of mitochondrial complex integrity. In almost all the measured pathways, the synbiotic formulation has a more robust impact than its individual components insinuating its combinatorial effect. The concomitant action of the gut microbiota on each of the key risk factors of aging and makes it a powerful therapeutic tool against neurodegeneration, diabetes, obesity, cardiovascular disease and other age-related chronic diseases.
Identification of a peptide for folate receptor alpha by phage display and its tumor targeting activity in ovary cancer xenograft
Authors: Xing Lijun , Xu Yifeng , Sun Keyong , Wang Hong , Zhang Fengguo , Zhou Zhengpin , Zhang Juan , Zhang Fang , Caliskan Bilgen , Qiu Zheng , Wang Min 
Published: May 2018

AbstractThe expression level of folate receptor alpha (FRα) is located highly rate in ovarian cancer though it is remained absent in normal tissues. This highly tumor restricted expression profile makes FRα a promising target for tumor therapy and diagnosis. In this research we report a FRα binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRα expressing cells by cell ELISA and flow cytometry. Tumor targeting ability of C7 was proved in vivo by both phage homing experiment and fluorescence imaging. C7 can be internalized by SKOV3 cells and its affinity to FRα was determined by MST. The molecular recognition was revealed by structure modeling, suggesting its binding mode with FRα.
Articulatory Range of Movement in Individuals With Dysarthria Secondary to Amyotrophic Lateral Sclerosis
Authors: Lee Jimin , Bell Michael 
Published: May 2018

Purpose
The current study examined overall articulatory range of movement (ROM) in individuals with amyotrophic lateral sclerosis (ALS). Differential involvement of articulators was also tested using articulatory working space in individuals with varying degrees of dysarthria severity and in typically aging individuals. A strong association between overall articulatory ROM and severity measures among individuals with ALS was hypothesized. In addition, it was hypothesized that differential involvement of articulators would be detected using overall articulatory ROM measures.

Method
Twenty-two speakers with dysarthria secondary to ALS and 22 typically aging speakers participated. Speech intelligibility and speaking rate were used as indices of severity. Movement range and overall articulatory working space area (convex hull) of the tongue, lower lip, and jaw were each measured by electromagnetic articulography while the speakers produced the Rainbow Passage.

Results
Tongue convex hull size was significantly correlated with both indices of severity. A significant interaction between articulators and groups was observed. Individuals with severe dysarthria had reduced tongue convex hull size and exaggerated lower lip convex hull size. ROM in the anterior–posterior dimension showed a more notable differential involvement pattern than ROM in the superior–inferior dimension. Results in the area under a receiver operating characteristic curve analysis revealed group-specific ROM sensitivity.

Conclusions
The findings indicate that tongue ROM is reduced in individuals with more severe dysarthria when estimated using a standardized paragraph containing all American English phonemes. The articulatory working space measure could be useful for estimating speech dysfunction in ALS. ROM of the tongue decreases, but ROM of the lower lip and jaw each increase in individuals with severe dysarthria. Differential involvement of the articulators in the anterior–posterior dimension needs to be further investigated.
A Duck Wearing Boots?! Pragmatic Language Strategies for Repairing Communication Breakdowns Across Genetically Based Neurodevelopmental Disabilities
Authors: Barstein Jamie , Martin Gary E. , Lee Michelle , Losh Molly 
Published: May 2018

PurposeThe ability to repair breakdowns in communication is an important pragmatic language skill that helps to maintain clear and meaningful interactions. Examining this ability in genetically based neurodevelopmental disabilities in which pragmatics are affected can provide important information about the precise pragmatic skills impacted across different populations and also help to identify core mechanisms underlying pragmatic impairment that may inform tailored interventions.MethodIndividuals with idiopathic autism spectrum disorder (ASD-O;n= 40), fragile X syndrome with comorbid autism spectrum disorder (FXS-ASD;n= 62), FXS without ASD (FXS-O;n= 38), Down syndrome (DS;n= 43), and typical development (TD;n= 42) completed a picture description task in which an examiner prompted for clarification repeatedly to elicit communication repair attempts. Participants' response strategies were compared across diagnostic groups and by sex and examined in relationship to different cognitive abilities.ResultsRelatively few group differences were observed in responses to requests for clarification overall. Males with ASD-O responded less to clarification requests than males with FXS-ASD and FXS-O, and males with FXS-ASD responded more inappropriately than males with ASD-O and DS. All male groups became less responsive to prompts for communication repair across the series of requests. Males with TD and FXS-ASD used less effective strategies than females.ConclusionAll groups showed some proficiency in repairing communication breakdowns, although individuals with ASD-O and FXS-ASD demonstrated some key areas of difficulty, highlighting the importance of considering ASD symptomatology in assessment and treatment of males with FXS. Findings also suggest that, across groups, multiple requests for clarification may lead to disengagement from the interaction. Finally, correlated skills observed across groups could implicate different underlying skills related to communication repair abilities across groups.
J-PLUS: Morphological star/galaxy classification by PDF analysis
Authors: López-Sanjuan C. , Vázquez Ramió H. , Varela J. , Spinoso D. , Angulo R. E. , Muniesa D. , Viironen K. , Cristóbal-Hornillos D. , Cenarro A. J. , Ederoclite A. , Marín-Franch A. , Moles M. , Ascaso B. , Bonoli S. , Chies-Santos A. L. , Coelho P. R. T. , Costa-Duarte M. V. , Cortesi A. , Díaz-García L. A. , Dupke R. A. , Galbany L. , Hernández-Monteagudo C. , Logroño-García R. , Molino A. , Orsi A. , Placco V. M. , Sampedro L. , San Roman I. , Vilella-Rojo G. , Whitten D. D. , Mendes de Oliveira C. L. , Sodré L. 
Published: May 2018

Aims. Our goal is to morphologically classify the sources identified in the images of the J-PLUS early data release (EDR) as compact (stars) or extended (galaxies) using a dedicated Bayesian classifier.
Methods. J-PLUS sources exhibit two distinct populations in the r-band magnitude versus concentration plane, corresponding to compact and extended sources. We modelled the two-population distribution with a skewed Gaussian for compact objects and a log-normal function for the extended objects. The derived model and the number density prior based on J-PLUS EDR data were used to estimate the Bayesian probability that a source is a star or a galaxy. This procedure was applied pointing-by-pointing to account for varying observing conditions and sky positions. Finally, we combined the morphological information from the g, r, and i broad bands in order to improve the classification of low signal-to-noise sources.
Results. The derived probabilities are used to compute the pointing-by-pointing number counts of stars and galaxies. The former increases as we approach the Milky Way disk, and the latter are similar across the probed area. The comparison with SDSS in the common regions is satisfactory up to r ~ 21, with consistent numbers of stars and galaxies, and consistent distributions in concentration and (g−i) colour spaces.
Conclusions. We implement a morphological star/galaxy classifier based on probability distribution function analysis, providing meaningful probabilities for J-PLUS sources to one magnitude deeper (r ~ 21) than a classical Boolean classification. These probabilities are suited for the statistical study of 150 thousand stars and 101 thousand galaxies with 15 < r ≤ 21 present in the 31.7 deg2 of the J-PLUS EDR. In a future version of the classifier, we will include J-PLUS colour information from 12 photometric bands.
Imageless navigation total hip arthroplasty – an evaluation of operative time
Authors: Valsamis Epaminondas Markos , Ricketts David , Hussain Adnan , Jenabzadeh Amir-Reza 
Published: May 2018

Introduction: Imageless navigation has been successfully integrated in knee arthroplasty but its effectiveness in total hip arthroplasty (THA) has been debated. It has consistently been shown that navigation adds significant time and cost to the operation. Further, the relative success of traditional hip replacements has impeded the adoption of new techniques.
Methods: We compared the operative time between fifty total hip replacements with and without the use of imageless navigation by a single senior surgeon in a retrospective study. We employed standard statistical tools to compare the two methods. A correlation-based analysis was used to delimit the “learned” phase of imageless navigation to make comparisons meaningful.
Results: Contrary to what has previously been reported, there was no significant difference between operative time in navigated, when compared to traditional operations (p = 0.498). Only fourteen operations were required to delimit the learning phase of this operation.
Discussion: This is the first study that demonstrates no added operative time when using imageless navigation in THA, achieved with an improved workflow. The results also demonstrate a very reasonable learning curve.
Erwartungen der Generation Y an das Führungsverhalten ihres
direkten Vorgesetzten im Vergleich zur Generation X und den Baby
Boomern
Authors: Huber Peter , Schubert Hans-Joachim 
Published: May 2018

Zusammenfassung
Zielsetzung Die Studie beschäftigt sich mit der Fragestellung, ob
Gesundheits- und Krankenpfleger der Generation Y (1981–1995) andere Erwartungen
an das Führungsverhalten ihres Vorgesetzten richten als Pflegekräfte der
Generationen X (1966–1980) und den Baby Boomern (1956–1965). Zusätzlich wurde
untersucht, welches Führungsverhalten Stationsleitungen und Pflegedirektoren für
die Generation Y als geeignet erachten und ob sich diese Annahmen zur Sichtweise
der Generation Y unterscheiden.
Methodik Im Rahmen einer quantitativen, deskriptiven Querschnittsstudie
mit dem Erhebungsinstrument MLQ 5X-Short wurden Führungskräfte des strategischen
Pflegemanagements (Pflegedirektoren) und operativen Managements
(Stationsleitungen) sowie Gesundheits- und Krankenpfleger befragt.
Ergebnisse In die Studie konnten n = 312 Pflegedirektoren, n = 259
Stationsleitungen und n = 421 Gesundheits- und Krankenpfleger eingeschlossen
werden. Die Generation Y stellt signifikant höhere Erwartungen an
transformationales Führungsverhalten als die Generationen X und Baby Boomer.
Führungskräfte schätzen im Vergleich zur Generation Y diese Erwartung geringer
ein.
Schlussfolgerungen Transformationales Führungsverhalten eignet sich
aufgrund der mehrfach bewiesenen positiven Effekte auf Motivation, Commitment
und Arbeitszufriedenheit um Mitarbeiter der Generation Y zu führen.
Identification of a Collagenase-Inhibiting Flavonoid from Alchemilla vulgaris Using NMR-Based Metabolomics
Authors: Mandrone Manuela , Coqueiro Aline , Poli Ferruccio , Antognoni Fabiana , Choi Young 
Published: May 2018

AbstractThis paper describes the use of 1H NMR profiling and chemometrics in order to facilitate the selection of medicinal plants as potential sources of collagenase inhibitors. A total of 49 plants with reported ethnobotanical uses, such as the healing of wounds and burns, treatment of skin-related diseases, rheumatism, arthritis, and bone diseases, were initially chosen as potential candidates. The in vitro collagenase inhibitory activity of hydroalcoholic extracts of these plants was tested. Moreover, their phytochemical profiles were analyzed by 1H NMR and combined with the inhibitory activity data by an orthogonal partial least squares model. The results showed a correlation between the bioactivity and the concentration of phenolics, including flavonoids, phenylpropanoids, and tannins, in the extracts. Considering the eventual false-positive effect on the bioactivity given by tannins, a tannin removal procedure was performed on the most active extracts. After this procedure, Alchemilla vulgaris was the most persistently active, proving to owe its activity to compounds other than tannins. Thus, this plant was selected as the most promising and further investigated through bioassay-guided fractionation, which resulted in the isolation of a flavonoid, quercetin-3-O-β-glucuronide, as confirmed by NMR and HRMS spectra. This compound showed not only a higher activity than other flavonoids with the same aglycone moiety, but was also higher than doxycycline (positive control), the only Federal Drug Administration-approved collagenase inhibitor. The approach employed in this study, namely the integration of metabolomics and bioactivity-guided fractionation, showed great potential as a tool for plant selection and identification of bioactive compounds in natural product research.
Are political representatives more risk-loving than the electorate? Evidence from German federal and state parliaments
Authors: Heß Moritz , von Scheve Christian , Schupp Jürgen , Wagner Aiko , Wagner Gert G. 
Published: May 2018

AbstractPolitical representatives frequently make decisions with far-reaching implications for citizens and societies. Most of these decisions are choices in situations in which the probabilities of gains and losses are hard to estimate. Although decision-making is crucial to politics, existing research has hardly ever addressed the political representation of traits that notably influence decision-making. One such trait is risk propensity; that is, an individual’s willingness to take risk. Using a unique dataset consisting of representative samples of the German Federal Parliament, four German State Parliaments, and the general German population, the present study investigates the degree to which political representatives’ risk propensity resembles their constituents’ appetite for risk. Not only descriptive results but even after using matching techniques and controlling for several potentially confounding variables, the study shows that political representatives are significantly more risk loving than the average citizen across several domains of risk taking. The implications of this finding are twofold. First, it points at a representation gap suggesting that politicians tend towards riskier choices than their voters, which not only affects politicians themselves but the entire polity. Second, it suggests a useful ‘division of labor’ according to which risk-loving politicians are prepared to take risks in exceptional situations, which their constituents would eschew.
Maturation of polycistronic mRNAs by the endoribonuclease RNase Y and its associated Y-complex inBacillus subtilis
Authors: DeLoughery Aaron , Lalanne Jean-Benoît , Losick Richard , Li Gene-Wei 
Published: May 2018

SignificanceBacterial operons must solve a fundamental problem: how to produce discordant amounts of proteins from cotranscribed genes. Here, we used a genome-wide approach to map operon mRNA isoforms with nucleotide resolution inBacillus subtilisand to quantify their abundances in different genetic backgrounds. These results revealed RNA endonucleolytic cleavages located in between cotranscribed genes that lead to differential transcript stability and abundance. The RNA endonuclease’s activity toward operon mRNA maturation requires a three-protein Y-complex. Interestingly, the Y-complex has few effects on other targets of the RNA endonuclease. The dichotomy of targets suggests that the Y-complex acts as a specificity factor for the general endonuclease, a role that could be broadly conserved in other Firmicutes, including the human pathogenStaphylococcus aureus.
Effects Sprayed Solution of Salicylic Acid to Prevent of Wilt Disease Caused by Fussarium oxysporium
Authors: Yousif Dina. Y. M. 
Published: May 2018

Abstract
The current search aimed to detective the effect of sprayed solution of salicylic acid on plant and leaves of sweet green pepper (Capsicum annuum) for control the pathogen Fussarium oxysporium compering with control plant and leaves. Results indicated that, the spray of salicylic acid at concentration 0.5 g/L is effecting the fungal infection through prevent transport fungus F. oxysporum to the neighboring green pepper plant. The number of dead green pepper plant after sprayed with solution of salicylic acid and only water they were (4, 6, and 3) (8, 9, and 10) respectively. While the experimental infection of green pepper leaves after inoculated the fungus as local spot by scorching small spots of these leaves with the aid of hot nail. These spots were then exposed to the 0.5 g/L aqueous solution salicylic acid before and after the inoculation of the fungus. The spray of salicylic acid before 24 and 48 hour prevent the development of disease and make a good protection of the mention leaves from infection with this fungus, the diameter of leaves lesion (1,1.5 cm) respectively. while the ability of fungus to grow after 24 and 48 hour from salicylic acid treatment was markedly reduce as compared with control, such treatment show slow growth of pathogen infect.
Outcomes of Acellular Dermal Matrix for Immediate Tissue Expander Reconstruction with Radiotherapy: A Retrospective Cohort Study
Authors: Craig Elizabeth S , Clemens Mark W , Koshy John C , Wren James , Hong Zhang , Butler Charles E , Garvey Patrick B , Selber Jesse C , Kronowitz Steven J 
Published: May 2018

Abstract

Background
Despite increasing literature support for the use of acellular dermal matrix (ADM) in expander-based breast reconstruction, the effect of ADM on clinical outcomes in the presence of post-mastectomy radiation therapy (PMRT) has not been well described.

Objectives
To analyze the impact ADM plays on clinical outcomes on immediate tissue expander (ITE) reconstruction undergoing PMRT.

Methods
We retrospectively reviewed patients who underwent ITE breast reconstruction from 2004 to 2014 at MD Anderson Cancer Center. Patients were categorized into four cohorts: ADM, ADM with PMRT, non-ADM, and non-ADM with PMRT. Outcomes and complications were compared among cohorts.

Results
Over 10 years, 957 patients underwent ITE reconstruction (683 non-ADM, 113 non-ADM with PMRT, 486 ADM, and 88 ADM with PMRT) with 1370 reconstructions. Overall complication rates for the ADM and non-ADM cohorts were 39.0% and 16.7%, respectively (P &lt; 0.001). Within both cohorts, mastectomy skin flap necrosis (MSFN) was the most common complication, followed by infection. ADM use was associated with a significantly higher rate of infections and seromas in both radiated and non-radiated groups; however, when comparing radiated cohorts, the incidence of explantation was significantly lower with the use of ADM.

Conclusions
The decision to use ADM for expander-based breast reconstruction should be performed with caution, given higher overall rates of complications, including infections and seromas. There may, however, be a role for ADM in cases requiring PMRT, as the overall incidence of implant failure is lower than non-ADM cases.

Level of Evidence: 3