bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders
Authors: Katisko Kasper , Cajanus Antti , Jääskeläinen Olli , Kontkanen Aleksi , Hartikainen Päivi , Korhonen Ville E. , Helisalmi Seppo , Haapasalo Annakaisa , Koivumaa-Honkanen Heli , Herukka Sanna-Kaisa , Remes Anne M. , Solje Eino 
Published: October 2019

Abstract
Due to the significant clinical overlap between frontotemporal lobar degeneration (FTLD) spectrum disorders and late-onset primary psychiatric disorders (PPD), diagnostic biomarkers reflecting the different underlying pathophysiologies are urgently needed. Thus far, elevated cerebrospinal fluid (CSF) levels of neurofilament light chain (NfL) have been reported in various neurological conditions. Furthermore, recent advancements in ultrasensitive analytical methods (e.g., single molecule array, Simoa) have enabled sensitive and less invasive NfL detection also from blood samples. In this study, we evaluated the potential of serum NfL (sNfL) as a diagnostic tool between FTLD and PPD. We analyzed sNfL levels with Simoa from 125 participants including patients from FTLD (n = 91) and PPD (n = 34) spectra. Our results show that sNfL levels are higher in the FTLD group compared to the PPD group as well as in separate clinical subtypes of FTLD compared to different psychiatric manifestations (i.e., mood or psychotic disorders). At single-subject level, discrimination between FTLD and PPD was possible with 80% sensitivity and 85% specificity (AUC = 0.850, 95% CI 0.776–0.923), and between behavioral variant frontotemporal dementia (bvFTD) and PPD with 79% sensitivity and 85% specificity (AUC = 0.830, 95% CI 0.732–0.908). These findings highlight the potential of sNfL as a discriminating biomarker for FTLD over PPD in patients with wide-ranging behavioral, psychiatric and cognitive symptoms.
Impact of the landfill of ashes from the smelter on the soil environment: case study from the South Poland, Europe
Authors: Twaróg Anna , Mamak Magdalena , Sechman Henryk , Rusiniak Piotr , Kasprzak Ewelina , Stanek Krzysztof 
Published: October 2019

Abstract
The following research describes the influence of a metallurgical ash dump on both the soil environment and the atmosphere. Soil samples were collected along a line positioned on an unprotected, hazardous ash dump and extended into the adjacent, arable land. Three soil depths were sampled at 0–20-, 20–40- and 40–60-cm depth intervals, and in each sample, pseudo-total concentrations of Cd, Cr, Cu, Fe, Mn, Ni, Pb, Ti, Zn, Li, Sr and V were analyzed. Additionally, emissions of CH4 and CO2 were measured at each sampling site. All emission measurements were taken in the same day, and the duration of gas measurements in each place was six minutes. The results demonstrate elevated concentrations of Cu, Cr, Pb and Zn on dump surface and along its margins, where the maximum concentrations of these elements are, respectively, 82, 23, 1144 and 8349 mg kg−1. Obtained results exceed several times both the natural background values and the values typical of local soils in the southern Poland. Moreover, natural background values for Fe, Mn, Ni, Li, Sr and V were exceeded, as well. Along the sampling line, no methane emission was detected, whereas the carbon dioxide flux varied from 7 to 42 g m−2 d−1. The reconnaissance study of the ash dump revealed a high contamination level of soils with heavy metals, which, together with the changes of soil environment, may cause migration of pollutants into the adjacent areas and, consequently, may generate hazard to the environment and, particularly, to the living organisms. Hence, further studies are necessary in order to evaluate the soil quality and the leaching of heavy metals from the dump.
Nitrogen balance in paddy fields under flowing-irrigation condition
Authors: Saiki Makoto , Nguyen Thi Phuong Mai , Shindo Junko , Nishida Kei 
Published: October 2019

Abstract
Flowing irrigation which drains a large volume of water is one of agricultural techniques for ensuring rice quality. In this study, the nitrogen input and output were characterised in paddy fields under flowing irrigation based on observation in Central Japan, and the estimated nitrogen loadings were compared to the reported values in traditional paddy fields under stagnant irrigation by using budget analysis. The annual water fluxes in the studied fields were calculated to be more than ten times larger than those in traditional fields. The concentrations of most nitrogen forms in surface drainage and subsurface drainage were detected at highest level during paddling periods, while those of nitrate and nitrite in subsurface drainage increased during non-irrigation periods. The total nitrogen inputs were at upper level (236–332 kg N ha−1) of or larger (490–581 kg N ha−1) than the reported values under both flowing irrigation and stagnant irrigation, and the larger contribution of irrigation pathway was observed. Surface drainage (78.3–163.5 kg N ha−1) and transport to underground system (73.1–210.4 kg N ha−1) were significantly higher than reported values obtained from stagnant-irrigation paddy fields. The differences between input and output were thereby estimated and the large negative balance was attributed to the soil accumulation, which was distinctly detected in the field with presumably higher adsorption capacity. Therefore, assessing the effect of water flow on soil nitrogen accumulation as well as discharge is recommended by evaluating nitrogen balance in paddy field.
Enhancing the Taxonomies Relating to Academic Integrity and Misconduct
Authors: Tauginienė Loreta , Gaižauskaitė Inga , Razi Salim , Glendinning Irene , Sivasubramaniam Shivadas , Marino Franca , Cosentino Marco , Anohina-Naumeca Alla , Kravjar Julius 
Published: October 2019

Abstract
A clear understanding of terminology is crucial in any academic field. When it is clear that complex interdisciplinary concepts are interpreted differently depending on the academic field, geographical setting or cultural values, it is time to take action. Given this, the Glossary for Academic Integrity, newly developed by the European Network for Academic Integrity project, served as the basis for compiling a comprehensive taxonomy of terms related to academic integrity. Following a rigorous coding exercise, the taxonomy was partitioned into three constituent components – Integrity, Misconduct and Neutral terms. A review of relevant literature sources is included, and the strengths and weaknesses of existing taxonomies are discussed in relation to this new offering. During the creation of these artefacts the authors identified and resolved many differences between their individual interpretative understandings of concepts/terms and the viewpoints of others. It is anticipated that the freely-available glossary and taxonomy will be explored and valued by researchers, teachers, students and the general public alike.
Complex response of an oscillating vertical cantilever with clearance
Authors: Łygas Krystian , Wolszczak Piotr , Litak Grzegorz , Sta̧czek Paweł 
Published: October 2019

Abstract
We study the dynamics of an elastic inverted pendulum with amplitude limiters excited horizontally. This particular model corresponds to a class of systems where a clearance is present naturally as an effect of imperfect clamping or it is included to tailor the response. We explore the complex responses of the system for a fixed value of amplitude clearance. The simulation and experimental results are analysed by a 0–1 test, Fourier, and wavelet transforms. The results show that the system can vibrate with subharmonic solution where the main response frequency of a flexible beam is 3 times lower than the excitaion frequency. We claim that an inverted pendulum with imperfect clamping of mechanical resonator can be used in broad frequency band energy harvesting.
Learning on the Edge: Investigating Boundary Filters in CNNs
Authors: Innamorati Carlo , Ritschel Tobias , Weyrich Tim , Mitra Niloy J. 
Published: October 2019

Abstract
Convolutional neural networks (CNNs) handle the case where filters extend beyond the image boundary using several heuristics, such as , or padding. These schemes are applied in an ad-hoc fashion and, being weakly related to the image content and oblivious of the target task, result in low output quality at the boundary. In this paper, we propose a simple and effective improvement that learns the boundary handling itself. At training-time, the network is provided with a separate set of boundary filters. At testing-time, we use these filters which have learned to extrapolate features at the boundary in an optimal way for the specific task. Our extensive evaluation, over a wide range of architectural changes (variations of layers, feature channels, or both), shows how the filters result in improved boundary handling. Furthermore, we investigate the efficacy of variations of such boundary filters with respect to convergence speed and accuracy. Finally, we demonstrate an improvement of 5–20% across the board of typical CNN applications (colorization, de-Bayering, optical flow, disparity estimation, and super-resolution). Supplementary material and code can be downloaded from the project page: http://geometry.cs.ucl.ac.uk/projects/2019/investigating-edge/.
Return-to-Play Practices Following Hamstring Injury: A Worldwide Survey of 131 Premier League Football Teams
Authors: Dunlop Gordon , Ardern Clare L. , Andersen Thor Einar , Lewin Colin , Dupont Gregory , Ashworth Ben , O’Driscoll Gary , Rolls Andrew , Brown Susan , McCall Alan 
Published: October 2019

Abstract

Purpose
Return-to-play (RTP) is an on-going challenge in professional football. Return-to-play related research is increasing. However, it is unknown to what extent the recommendations presented within research are being implemented by professional football teams, and where there are gaps between research and practice. The purposes of this study were (1) to determine if premier-league football teams worldwide follow a RTP continuum, (2) to identify RTP criteria used and (3) to understand how RTP decision-making occurs in applied practice.

Methods
We sent a structured online survey to practitioners responsible for the RTP programme in 310 professional teams from 34 premier-leagues worldwide. The survey comprised four sections, based on hamstring muscle injury: (1) criteria used throughout RTP phases, (2) the frequency with which progression criteria were achieved, (3) RTP decision-making process and (4) challenges to decision-making.

Results
One-hundred and thirty-one teams responded with a completed survey (42%). One-hundred and twenty-four teams (95%) used a continuum to guide RTP, assessing a combination of clinical, functional and psychological criteria to inform decisions to progress. One-hundred and five (80%) teams reported using a shared decision-making approach considering the input of multiple stakeholders. Team hierarchy, match- and player-related factors were common challenges perceived to influence decision-making.

Conclusions
General research recommendations for RTP and the beliefs and practices of practitioners appear to match with, the majority of teams assessing functional, clinical and psychological criteria throughout a RTP continuum to inform decision-making which is also shared among key stakeholders. However, specific criteria, metrics and thresholds used, and the specific involvement, dynamics and interactions of staff during decision-making are not clear.
What is geriatric rehabilitation and how should it be organized? A Delphi study aimed at reaching European consensus
Authors: van Balen Romke , Gordon Adam L. , Schols Jos M. G. A. , Drewes Yvonne M. , Achterberg Wilco P. 
Published: October 2019

AbstractPurposeMany European countries have developed services to rehabilitate the increasing number of older people who experience an acute or subacute decrease in function after a medical event such as a hip fracture or stroke. However, there are important differences between countries regarding patient selection, organization of services, length of stay, and content of the rehabilitation process. The lack of consensus around, and quality criteria for, geriatric rehabilitation limits opportunities for exchange of best practice and scientific research.Methods33 experts, mostly geriatricians with experience in geriatric rehabilitation, from 18 European countries were invited to participate in a modified Delphi study. They were asked to react to 68 statements using a five-point Likert scale. The statements were formulated on the basis of literature review and practice experience, and were initially piloted among Dutch elderly care physicians. Consensus was defined beforehand as an Interquartile Range (IQR) of </= 1 for each statement.ResultsConsensus was reached on 61 (90%) statements after two rounds. The resulting consensus covers: the need for a multidisciplinary approach to Geriatric Rehabilitation after CGA; inclusion of patients with temporary confusion or cognitive decline; use of structured goal-oriented rehabilitation plans; the necessity of an early start of rehabilitation; preference for ambulatory rehabilitation or Geriatric Rehabilitation at home; the advantage of protocolled treatment programs; the need for consensus on patient outcome assessment instruments; and education and training in Geriatric Rehabilitation for healthcare professionals.ConclusionThese consensus statements provide a first step towards more coherent organization and delivery of geriatric rehabilitation across Europe.
Promotion and tenure policies for team science at colleges/schools of medicine
Authors: McHale Susan M. , Ranwala Damayanthi (Dayan) , DiazGranados Deborah , Bagshaw Dee , Schienke Erich , Blank Arthur E. 
Published: October 2019

AbstractIntroduction:Advancing understanding of human health promotion and disease prevention and treatment often requires teamwork. To evaluate academic medical institutions’ support for team science in the context of researchers’ career development, we measured the value placed on team science and specificity of guidance provided for documenting team science contributions in the promotion and tenure (P&T) documents of Colleges/Schools of Medicine (CoMs) in the National Center for Advancing Translational Sciences’ Clinical and Translational Science Award (CTSA) program.Method:We reviewed complete P&T documents from 57 of 63 CTSA CoMs to identify career paths defined by three dimensions: academic rank (associate versus full professor), tenure eligibility (tenure track versus not), and role (research, clinical, education, and administrative), and we rated team science value and documentation guidance for each path. Multilevel models were estimated to compare team science value and documentation guidance as a function of the three career path dimensions while accounting for the clustered data (N = 357 career paths within 57 CoMs).Results:Team science value was greater for associate than full professors, non-tenure-eligible versus tenure-eligible positions, and roles prioritizing clinical, education, and administrative responsibilities versus those prioritizing research. Guidance for documenting team science achievements was more explicit for roles that prioritized research.Discussion:Although P&T policies at most CTSA institutions express value for team science, inconsistent within-institutional patterns of recognition and reward across career paths may have implications for researchers’ involvement in team science. We discuss the implications of our findings for research and for P&T policies that promote team science.
Anaphylaxis and anaphylactoid reactions associated with the insertion of peripherally inserted central catheters: A multiyear comparative retrospective cohort study
Authors: Thornton Christina S. , Dumanski Jody , Margherit Cherylanne , Vaz-Gonsalves Sandra , McDiarmid Sheryl , Parkins Michael D. , Conly John M. 
Published: October 2019

AbstractObjective:Peripherally inserted central catheters (PICCs) are a mainstay of nonpermanent vascular access devices. In this study, we assessed patients displaying anaphylaxis or anaphylactoid reactions to the PowerPICC SOLO and Groshong PICC (Bard Access Systems) using the Sherlock tip locating system (TLS).Methods:Patients from 2 tertiary-care hospitals were systematically monitored over 4 years for adverse events following the insertion of a PICC using the Sherlock TLS. Insertion data were also collected using the BioFlo PICC (Angiodynamics)from a third hospital site and from The Ottawa Hospital over 4 years as an additional comparator. Three definitions of anaphylaxis and anaphylactoid reactions were utilized, and the Cohen κ was used to assess interrater agreement. Analysis of reactions among the patient cohorts was performed using the χ2 test with Yates correction or the Fisher exact test as appropriate.Results:Among 8,257 insertions using the TLS PICCs, 37 potential reactions (0.45%) were recorded. Using specific definitions for anaphylaxis or anaphylactoid reactions, 54.1%–91.9% met criteria. Comparator populations using data from Calgary (n = 491) and Ottawa (n = 7,889) using the BioFlo PICC insertion found no reactions. Anaphylactic or anaphylactoid reactions were significantly associated with the PowerPICC SOLO and Groshong PICC with the TLS compared to the BioFlo PICC (P < .0001) across all definitions. The largest subset of patients experiencing adverse reactions had cystic fibrosis (CF) (n = 4, 10.8%).Conclusion:Our study results demonstrate significant adverse events associated with the PowerPICC SOLO and Groshong PICC using the Sherlock TLS inserted across a range of patient populations. The incidence rate of anaphylaxis or anaphylactoid reactions in the CF population at our center is significantly higher than in non-CF patients (P < .001).
Collision Detection on Industrial Robots in Repetitive Tasks Using Modified Dynamic Time Warping
Authors: Gordić Zaviša , Jovanović Kosta 
Published: October 2019

SUMMARYThis paper presents a non-model-based collision detection algorithm for robots without external sensors and with closed control architecture. A reference signal of repetitive motion is recorded from the robot operation. To detect collisions, the reference is compared with measurements from the robot. One of the key contributions is a novel approach to optimal matching of compared signals, which is ensured by the newly developed modified Dynamic Time Warping (mDTW) method presented in this paper. One of the main improvements of the mDTW is that it enables comparing a signal with the most similar section of the other signal. Partial matching also enables online application of time warping principles and reduces the time and computation resources needed to perform matching. In addition to mDTW, two complementary decision rules are developed to identify collisions. The first rule, based on the absolute difference between compared matched samples, uses statistically determined thresholds to perform rapid detection of unambiguous collisions. The second rule is based on Eigen values of the covariance matrix of matched samples, and it employs its higher sensitivity to detect collisions with lower intensity. Results from experimental validation of the proposed collision algorithm on two industrial robots are shown.
Multimodality cardiovascular imaging in the diagnosis and management of prosthetic valve infective endocarditis in children report of two cases and brief review of the literature
Authors: Chau Ariya , Renella Pierangelo , Arrieta Antonio 
Published: October 2019

AbstractDiagnosing prosthetic valve infective endocarditis in children is challenging. Transthoracic and transesophageal echocardiography can yield false-negative results. Data are lacking in paediatric multimodality imaging in prosthetic valve infective endocarditis. We present two children with repaired CHD where initial echocardiogram was non-diagnostic, while CT angiogram and 18F-fluorodeoxyglucose positron emission tomography in combination with CT angiography, respectively, confirmed the diagnosis of endocarditis affecting clinical management.
Towards a theory of the transformation of the developmental state: political elites, social actors and state policy constraints in South Korea and Taiwan
Authors: He Tian 
Published: October 2019

AbstractThe institutional changes to the developmental states in South Korea and Taiwan have been well-documented. This paper offers a theory to recount the states' actual transformation processes in these two cases. Advancing existing insight that the state's transformation process is shaped by the emergence of either concentrated or dispersed economic interests, I argue that a crucial process behind the transformation of the developmental state is a democratic transition of a country motivated by ruling elites' strategic choices. Specifically, a democratic transition in a developmental state is shaped by two consecutive elite decisions: (1) the decision to initiate democratic transition in response to the democratic mobilisation of the middle class; (2) the decision to introduce democratic elections in response to an electoral threat from opposition elites. This process of democratic transition facilitates the emergence of state policy constraints by transforming the political foundation of the state.
Trading privileges for support: the strategic co-optation of emerging powers into international institutions
Authors: Kruck Andreas , Zangl Bernhard 
Published: October 2019

AbstractAs emerging powers rise and established powers decline, international institutions come under pressure to adjust to new power realities. When and how do international institutions adapt to underlying global power shifts? We propose an (institutionalist) theory of strategic co-optation that differs from both (realist) accommodationist and (liberal) integrationist theories. Drawing on isolated treatments of strategic co-optation from other domains – domestic and international, autocratic and democratic, past and present – we develop a theory of strategic co-optation as a mode of institutional adaption to shifts in the global distribution of power. The theory specifies the concept, the conditions and the (unintended) consequences of strategic co-optation. We conceptualize co-optation as a specific form of adaptation where established powers trade institutional privileges for emerging powers' institutional support. We theorize the conditions under which emerging and established powers are (more or less) likely to strike a co-optation deal. In addition, we identify endogenous dynamics that may render co-optation precarious and thus subject to instabilities. While the ambition of this paper is primarily theoretical, we provide various empirical illustrations of how strategic co-optation is used to adapt international institutions to contemporary shifts in the global distribution of power.