bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival benefits of adjuvant radiation in the management of early tongue cancer with depth of invasion as the indication
Authors: Rajappa Suhas Kodasoge , Ram Dharma , Bhakuni Yogendra Singh , Jain Ankita , Kumar Rajeev , Dewan Ajay K. 
Published: June 2018

AbstractBackgroundWith the introduction of new American Joint Committee on Cancer (AJCC) classifications for head and neck cancers few cases are upgraded from T2 to T3 based only on depth of invasion. The role of adjuvant therapy in this particular subset of patients is still not defined.MethodsThis is a retrospective analysis of data from 2009 to 2015, of patients with histopathology of pT1, T2, and N0. A total of 375 patients were subdivided into 3 groups per the new AJCC classification depth of invasion <5 mm, 6 to 10 mm, and >10 mm. Survival analyses of patients receiving adjuvant therapy and those who did not were compared with specific emphasis on patients who were upstaged from T2 to T3 based on depth of invasion.ResultsDepth of invasion is a poor prognostic factor and addition of adjuvant therapy based on depth of invasion did not have significant survival benefits.ConclusionAddition of adjuvant therapy based on depth of invasion does not influence survival in patients with early carcinoma of the tongue.
A closed formula for calculating pesticide residue levels in the feed items of terrestrial species
Authors: Van Cott Cornelia , Van Cott Andrew , Gagne James 
Published: June 2018

Abstract

Calculating pesticide residue levels in feed items for terrestrial species requires accounting for the application rate of the pesticide, the frequency and interval of application, the half-life of the pesticide on the food item, and the residue unit dose. Microsoft Excel™–based applications such as the US Environmental Protection Agency's Terrestrial Residue Exposure model (T-REX) and Terrestrial Herpetofaunal Exposure Residue Program (T-HERPS) calculate the residue levels in feed items using a recursive sequence. A recursive sequence is an unwieldy calculation method that presents a barrier to creating a software-based tool capable of conducting flexible assessments. Therefore, we determined the closed form of the recursive mathematical equation used by both T-REX and T-HERPS. With this formula, we can both duplicate screening-level assessments (T-REX, T-HERPS) as well as incrementally refine the assessment with data-driven inputs. Integr Environ Assess Manag 2018;14:703–709. © 2018 SETAC

Key Points
We determined the closed form of the recursive mathematical equation used by both the Terrestrial Residue Exposure model (T-REX) and the Terrestrial Herpetofaunal Exposure Residue Program (T-HERPS). With this formula, applications can be created that use data-driven inputs not currently allowed by T-REX or T-HERPS.
NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover
Authors: Scholtysek Carina , Ipseiz Natacha , Böhm Christina , Krishnacoumar Brenda , Stenzel Martin , Czerwinski Tina , Palumbo-Zerr Katrin , Rothe Tobias , Weidner Daniela , Klej Alexandra , Stoll Cornelia , Distler Jörg , Tuckermann Jan , Herrmann Martin , Fabry Ben , Goldmann Wolfgang H , Schett Georg , Krönke Gerhard 
Published: June 2018

ABSTRACT

NR4A1 (Nur77 or NGFI-B), an orphan member of the nuclear receptor superfamily, has been identified as a key regulator of the differentiation and function of myeloid, lymphoid, and mesenchymal cells. The detailed role of NR4A1 in bone biology is incompletely understood. Here, we report a role for NR4A1 as novel factor controlling the migration and recruitment of osteoclast precursors during bone remodeling. Myeloid-specific but not osteoblast-specific deletion of NR4A1 resulted in osteopenia due to an increase in the number of bone-lining osteoclasts. Although NR4A1-deficient osteoclast precursors displayed a regular differentiation into mature osteoclasts, they showed a hyper-motile phenotype that was largely dependent on increased osteopontin expression, suggesting that expression of NR4A1 negatively controlled osteopontin-mediated recruitment of osteoclast precursors to the trabecular bone. Pharmacological activation of NR4A1, in turn, inhibited osteopontin expression and osteopontin-dependent migration of osteoclast precursors resulted in reduced abundance of bone-resorbing osteoclasts in vivo as well as in an ameliorated bone loss after ovariectomy in mice. This study identifies NR4A1 as a crucial player in the regulation of osteoclast biology and bone remodeling and highlights this nuclear receptor as a promising target for therapeutic intervention during the treatment of osteoporosis. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.
Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer
Authors: Nerviani Alessandra , Pitzalis Costantino 
Published: June 2018

Abstract
Ectopic (or tertiary) lymphoid structures (ELS) are organized aggregates of lymphocytes resembling secondary lymphoid organs and developing in chronically inflamed nonlymphoid tissues during persistent infections, graft rejection, autoimmune conditions, and cancer. In this review, we will first depict the mechanisms regulating ELS generation, focusing on the role played by lymphoid chemokines. We will then characterize ELS forming in target organs during autoimmune conditions, here exemplified by rheumatoid arthritis, and cancer, highlighting the relevance of the tissue-specific factors. Finally, we will discuss the clinical significance of ELS and the therapeutic potential of their inhibition and/or enhancement depending on the disease considered.
Review of how lymphoid chemokines regulate the ectopic development of lymphoid structures in ‘permissive’ tissues during chronic inflammation.
The ypT category does not impact overall survival in node negative gastric cancer
Authors: Ikoma Naruhiko , Hofstetter Wayne L. , Estrella Jeannelyn S. , Das Prajnan , Minsky Bruce D. , Fournier Keith F. , Mansfield Paul F. , Ajani Jaffer A. , Badgwell Brian D. 
Published: June 2018

BackgroundAlthough the eighth‐edition American Joint Committee on Cancer (AJCC) gastric cancer staging system created ypTNM staging for patients who underwent preoperative therapy, the ideal ypTNM grouping is unknown. We sought to investigate risk factors for OS in ypT0‐3N0M0 gastric cancer.MethodsFrom an institutional database of The University of Texas MD Anderson Cancer Center and the National Cancer Database (NCDB), we identified patients with ypT0‐3N0M0 gastric adenocarcinoma who underwent R0 gastrectomy after chemotherapy or chemoradiation during 1995‐2015 (MD Anderson) or 2006‐2014 (NCDB).ResultsThe study included 175 MD Anderson and 3200 NCDB patients. By multivariable analysis, ypT category was not associated with OS (hazard ratio [HR] for ypT3 vs ypT1: MD Anderson, 0.83 [95% CI, 0.36‐1.92], P = 0.669; NCDB, 0.96 [95% CI, 0.85‐1.08], P = 0.472). cN‐positive disease was not associated with OS in the MD Anderson cohort (HR, 0.96 [95% CI, 0.55‐1.67]; P = 0.873) but was weakly associated with shorter OS in the NCDB cohort (HR, 1.11 [95% CI, 1.01‐1.21]; P = 0.031).ConclusionsThe ypT category does not impact OS in ypT0‐3N0M0 gastric cancer. The impact of cN status on OS appeared limited. These findings should be considered in future systems of post‐neoadjuvant pathologic staging.
Microstructure transformation and physical and mechanical properties of ultrafine‐grained and nanocrystalline TiNi alloys in multiple martensitic transformations B2‐B19’
Authors: Churakova A.A. , Gunderov D.V. , Dmitriev S.V. 
Published: June 2018

AbstractComprehensive studies on the impact of multiple martensitic transformations B2‐B19′ on the structure and properties of ultrafine‐grained and nanocrystalline titanium‐nickel alloys are implemented. It is shown that in coarse‐grained, ultrafine‐grained and nanocrystalline titanium‐nickel alloys consecutive changes in the structure and properties take place, which are induced by phase hardening, when the number of thermocycles increases up to n = 100 with quick heating and quick cooling to ‐196 °C. During thermal cycling of coarse‐grained and ultrafine‐grained Ti50Ni50 alloys via the chosen regimes, the direction of martensitic transformation temperatures changes. First the temperatures reduce, then they increase with the number of thermocycles growing. The transformation temperatures in the ultrafine‐grained state of Ti49.15Ni50.85 are more resistant to thermal cycling than in the coarse‐grained state. Phase hardening occurs more intensively in ultrafine‐grained states of the studied titanium‐nickel alloys than in coarse‐grained state.
Angiographers no longer need to avoid digital zoom
Authors: Cecil Robert A. , Heupler Frederick , Shkumat Nicholas , Ellis Stephen , Kapadia Samir , Fares Haitham , Agarwal Ashok 
Published: June 2018

AbstractThe physics of angiographic digital flat‐panel detectors suggests that no increase in dose is required for appropriate image quality in image‐magnified fields of view. This is contrary to current practice. A dose‐saving protocol decreased radiation dose by an average of 32% for these zoomed fields of view with no observable image quality degradation. This change in protocol may be applicable across all manufactures of flat‐panel angiographic systems. Angiographers may preferentially use reduced‐dose zoomed fields to minimize scatter radiation, assure anatomical conspicuity and reduce patient radiation burden.
Fetal cerebral hemorrhage due to X‐linkedGATA1gene mutation
Authors: Bouchghoul Hanane , Quelin Chloé , Loget Philippe , Encha‐Razavi Féréchté , Senat Marie‐Victoire , Maheut Lorraine , Galimand Julie , Collardeau‐Frachon Sophie , Da Costa Lydie , Martinovic Jelena 
Published: June 2018

AbstractWe report a multiplex family with aGATA1gene mutation responsible for a massive fetal cerebral hemorrhage occurring at 36 weeks. Two other stillbirth cousins presented with fetal hydrops and congenital hemochromatosis' phenotype at 37 and 12 weeks of gestation. Molecular screening revealed the presence of a c.613G>A pathogenic allelic variation in exon 4 ofGATA1gene in the 3 male siblings and their carrier mothers.The diagnosis of aGATA1gene mutation may be suspected in cases of male fetuses with intracerebral bleeding, particularly if a history of prior fetal loss(es) and mild maternal thrombocytopenia are also present.
The effect of light conditions on interpreting oil composition engineering in Arabidopsis seeds
Authors: Karki Nischal , Bates Philip D. 
Published: June 2018

AbstractArabidopsis thaliana is the most developed and utilized model plant. In particular, it is an excellent model for proof‐of‐concept seed oil engineering studies because it accumulates approximately 37% seed oil by weight, and it is closely related to important Brassicaceae oilseed crops. Arabidopsis can be grown under a wide variety of conditions including continuous light; however, the amount of light is strongly correlated with total seed oil accumulation. In addition, many attempts to engineer novel seed oil fatty acid compositions in Arabidopsis have reported significant reductions in oil accumulation; however, the relative reduction from the nontransgenic controls varies greatly within the literature. A set of experiments were conducted to systematically analyze the effect of light conditions (including day/night cycle vs. continuous light, and different light intensities) on the relative accumulation of seed oil between three different transgenic lines producing novel hydroxy fatty acids and their nontransgenic background. Oil content was measured per seed and as a percentage of seed weight. Our results indicate the relative amount of seed oil between transgenic lines and nontransgenic controls is dependent on both the light conditions and the type of oil content measurement utilized. In addition, the light conditions effect the relative accumulation of the novel fatty acids between various transgenic lines. Therefore, the success of novel fatty acid proof‐of‐concept engineering strategies on both oil accumulation and fatty acid composition in Arabidopsis seeds should be considered in light of the select growth and measurement conditions prior to moving engineering strategies into crop plants.
An Algorithm for Evaluation of Potential Hazards in Research and Development of New Energetic Materials in Terms of their Detonation and Ballistic Profiles
Authors: Bondarchuk Sergey V. , Yefimenko Nadezhda A. 
Published: June 2018

AbstractIn the present paper we report recommendations for safe handling with unknown explosive materials and compositions. These are based on quantum‐chemical evaluations of the detonation and ballistic profiles of newly synthesized explosives and their comparison with the known reference compounds. The proposed methodology is rather simple, fast and does not require special skills. Meanwhile, it allows an effective quenching of the potential risk associated with injuries caused by accidental explosions. Additionally, we have developed two utilities, which significantly simplify the calculation process. The proposed algorithm was found to be more successful in estimation of detonation velocity of several common explosives in comparison with commercially available software EMDB, EXPLO5 and Cheetah 8.0. The reported results will be useful for scientific personnel working in the field of development and testing of explosives.
Identification and preliminary study of immunogens involved in autoimmune prostatitis in human males
Authors: Lu Jin‐Chun , Shen Jia‐Ming , Hu Xue‐Chun , Peng Long‐Ping , Hong Zhi‐Wei , Yao Bing 
Published: June 2018

BackgroundExperimental models have confirmed that autoimmunity is an important factor in the onset of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); however, there is no conclusive evidence on whether autoimmune prostatitis exists in human males.MethodsRabbits were immunized with either human prostate tissue homogenates or normal saline and the antiserum was collected. Two‐dimensional electrophoresis (2‐DE) was performed on the homogenates and Western blotting was conducted on the sera. The identified human prostate tissue immunodominant antigens (HPTIAs) were detected by mass spectrometry. The serum immunoglobulin (Ig)G from the immunized rabbits was purified with protein A‐agarose, and the purified IgG was linked with Sepharose to purify HPTIAs by affinity chromatography. Non‐obese diabetic (NOD) mice were immunized with the purified HPTIAs, and the levels of serum antibodies, INF‐γ, and histopathological changes in their prostate tissues were detected. The purified HPTIAs were coated into polystyrene pores and serum autoantibodies in CP/CPPS patients were detected by enzyme‐linked immunosorbent assay (ELISA). Meanwhile, serum interleukin 2 (IL‐2), interferon gamma (IFNγ), and tumor necrosis factor alpha (TNFα) levels in CP/CPPS patients were also determined by ELISA.ResultsSixteen HPTIAs were identified. Among them, three types were reported to be associated with prostatic diseases. Prostatitis was induced in mice immunized with the 16‐HPTIA complex, with positive serum autoantibody and increased prostatic IFN‐γ levels. The positive rate of serum autoantibodies against HPTIAs was significantly higher in CP/CPPS patients (23.1%, 18/78) than in the control (2.7%, 2/75). But there was no significant difference in serum TNFα, IFNγ, and IL‐2 levels between the CPPS patients with positive and negative autoantibodies against HPTIAs.ConclusionsAutoantibodies against HPTIAs exist in part in CP/CPPS patients, which implies that autoimmunity and the 16 HPTIAs are important factors in the onset of CP/CPPS. The detection of serum autoantibodies could be applied in clinical diagnoses of autoimmune prostatitis; treatment protocols might change. Additional studies are needed to determine which of the 16 HPTIAs is the most important.
4′‐Phenyl‐2,2′:6′,2′′‐terpyridine Derivatives Containing 1‐Substituted‐2,3‐Triazole Ring: Synthesis, Characterization and Anticancer Activity
Authors: Zych Dawid , Slodek Aneta , Krompiec Stanisław , Malarz Katarzyna , Mrozek‐Wilczkiewicz Anna , Musiol Robert 
Published: June 2018

AbstractTerpyridine moiety is known for chelating and interesting physicochemical properties enabling some applications. Its biological activity, particularly anticancer potency is not well studied. Herein we present six 4′‐(1‐substituted‐2,3‐triazol‐4‐yl)phenyl‐2,2′:6′,2′′‐terpyridine derivatives with glycidyl, cyclohexylmethyl, benzyl, 4‐tert‐butylbenzyl, pentafluorobenzyl, and 2,6‐dichlorobenzyl groups which were obtained via Cu(I)‐catalysed 1,3‐dipolar cycloaddition reaction. The photophysical such as optical (absorption and photoluminescence spectra, quantum yields and lifetimes) and thermal (by using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA)) properties were examined. In addition, theoretical studies (DFT and TD‐DFT) were performed to provide a deeper understanding of the experimental results. In vitro studies on the obtained novel structures were conducted with selected series of cell lines to check their bioactivity and toxicity. The most active compound reached a nanomolar level with good selectivity index better than doxorubicin. Mechanism of action for these terpyridines was also investigated which suggest intercalation of DNA as a trigger of cell death.
FeP@C Nanotube Arrays Grown on Carbon Fabric as a Low Potential and Freestanding Anode for High‐Performance Li‐Ion Batteries
Authors: Xu Xijun , Liu Jun , Liu Zhengbo , Wang Zhuosen , Hu Renzong , Liu Jiangwen , Ouyang Liuzhang , Zhu Min 
Published: June 2018

AbstractAn anode of self‐supported FeP@C nanotube arrays on carbon fabric (CF) is successfully fabricated via a facile template‐based deposition and phosphorization route: first, well‐aligned FeOOH nanotube arrays are simply obtained via a solution deposition and in situ etching route with hydrothermally crystallized (Co,Ni)(CO3)0.5OH nanowire arrays as the template; subsequently, these uniform FeOOH nanotube arrays are transformed into robust carbon‐coated Fe3O4 (Fe3O4@C) nanotube arrays via glucose adsorption and annealing treatments; and finally FeP@C nanotube arrays on CF are achieved through the facile phosphorization of the oxide‐based arrays. As an anode for lithium‐ion batteries (LIBs), these FeP@C nanotube arrays exhibit superior rate capability (reversible capacities of 945, 871, 815, 762, 717, and 657 mA h g−1 at 0.1, 0.2, 0.4, 0.8, 1.3, and 2.2 A g−1, respectively, corresponding to area specific capacities of 1.73, 1.59, 1.49, 1.39, 1.31, 1.20 mA h cm−2 at 0.18, 0.37, 0.732, 1.46, 2.38, and 4.03 mA cm−2, respectively) and a stable long‐cycling performance (a high specific capacity of 718 mA h g−1 after 670 cycles at 0.5 A g−1, corresponding to an area capacity of 1.31 mA h cm−2 at 0.92 mA cm−2).
Quality of Meliponinae honey: Pesticides residues, pollen identity, and microbiological profiles
Authors: Rodrigues Carina da Silva , Ferasso Debora Cristina , Prestes Osmar Damian , Zanella Renato , Grando Remili Cristiani , Treichel Helen , Coelho Geraldo Ceni , Mossi Altemir José 
Published: June 2018

AbstractThis study aims at evaluating the quality of honey of Melipona quadrifasciata quadrifasciata Tetragonisca angustula and Scaptotrigona depilis. Pollen analysis was performed to identify the floral resources used for the production of honey, and 19 pollen types were identified. Microbiological analyses identified the presence of coliforms, molds, and yeasts, but Clostridium botulinum was not found. Using the modified “Quick, Easy, Cheap, Effective, Rugged, and Safe” method followed by ultra‐high performance liquid chromatography‐tandem mass spectrometry determination, eight pesticides were detected in the honey of T. angustula and only two in the honey from S. depilis. The honey of M. q. quadrifasciata did not present pesticide residues. The data pointed out the relevance of good practices to avoid the contamination of honey with sources of microbiological contaminants, which may impair the product's safety for human consumption.
Every Child, Every Classroom, Every Day: From Vision to Action in Literacy Learning
Authors: Fountas Irene C. , Pinnell Gay Su 
Published: June 2018

AbstractImproving literacy outcomes for each and every student is a goal worthy of educators’ best efforts. This high goal is made more challenging by shifting mandates in education that can leave literacy professionals and school leaders disoriented, seeking a guaranteed fix. The authors propose a more coherent, more effective way to attain this goal: thinking of the school as a system. The authors discuss four essential elements for designing a schoolwide system for literacy learning: a shared vision and set of core values; common goals, common language, and collective responsibility; a high level of teacher expertise; and a culture of continuous professional learning.
Gravitational memory in higher dimensions
Authors: Pate Monica , Raclariu Ana-Maria , Strominger Andrew 
Published: June 2018

AbstractIt is shown that there is a universal gravitational memory effect measurable by inertial detectors in even spacetime dimensionsd≥ 4. The effect falls off at large radiusrasr3−d. Moreover this memory effect sits at one corner of an infrared triangle with the other two corners occupied by Weinberg’s soft graviton theorem and infinite-dimensional asymptotic symmetries.
Scale invariance with fundamental matters and anomaly: a holographic description
Authors: Banerjee Avik , Kundu Arnab , Ray Augniva 
Published: June 2018

AbstractGenerally, quantum field theories can be thought as deformations away from conformal field theories. In this article, with a simplebottom upmodel assumed to possess a holographic description, we study a putative largeNquantum field theory with large and arbitrary number of adjoint and fundamental degrees of freedom and a non-vanishing chiral anomaly, in the presence of an external magnetic field and with a non-vanishing density. Motivated by the richness of quantum chromodynamics under similar condition, we explore the solution space to find an infinite class of scale-invariant, but not conformal, field theories that may play a pivotal role in defining the corresponding physics. In particular, we find two classes of geometries: Schrödinger isometric and warped AdS3geometries with an SL(2, R)×U(1) isometry. We find hints of spontaneous breaking of translational symmetry, at low temperatures, around the warped backgrounds.