bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the impact of analysis software on task fMRI results
Authors: Bowring Alexander , Maumet Camille , Nichols Thomas E. 
Published: May 2019

AbstractA wealth of analysis tools are available to fMRI researchers in order to extract patterns of task variation and, ultimately, understand cognitive function. However, this “methodological plurality” comes with a drawback. While conceptually similar, two different analysis pipelines applied on the same dataset may not produce the same scientific results. Differences in methods, implementations across software, and even operating systems or software versions all contribute to this variability. Consequently, attention in the field has recently been directed to reproducibility and data sharing. In this work, our goal is to understand how choice of software package impacts on analysis results. We use publicly shared data from three published task fMRI neuroimaging studies, reanalyzing each study using the three main neuroimaging software packages, AFNI, FSL, and SPM, using parametric and nonparametric inference. We obtain all information on how to process, analyse, and model each dataset from the publications. We make quantitative and qualitative comparisons between our replications to gauge the scale of variability in our results and assess the fundamental differences between each software package. Qualitatively we find similarities between packages, backed up by Neurosynth association analyses that correlate similar words and phrases to all three software package's unthresholded results for each of the studies we reanalyse. However, we also discover marked differences, such as Dice similarity coefficients ranging from 0.000 to 0.684 in comparisons of thresholded statistic maps between software. We discuss the challenges involved in trying to reanalyse the published studies, and highlight our efforts to make this research reproducible.
Enhanced lateral resolution in continuous wave stimulated emission depletion microscopy using tightly focused annular radially polarized excitation beam
Authors: Lim Geon , Kim Wan‐Chin , Oh Seunghee , Lee Hyungsuk , Park No‐Cheol 
Published: May 2019

AbstractThe lateral resolution of continuous wave (CW) stimulated emission depletion (STED) microscopy is enhanced about 12% by applying annular‐shaped amplitude modulation to the radially polarized excitation beam. A focused annularly filtered radially polarized excitation beam provides a more condensed point spread function (PSF), which contributes to enhance effective STED resolution of CW STED microscopy. Theoretical analysis shows that the FWHM of the effective PSF on the detection plane is smaller than for conventional CW STED. Simulation shows the donut‐shaped PSF of the depletion beam and confocal optics suppress undesired PSF sidelobes. Imaging experiments agree with the simulated resolution improvement.
RETRACTED: Downregulation of microRNA‐205 inhibits cell invasion and angiogenesis of cervical cancer through TSLC1‐mediated Akt signaling pathway
Authors: Zhang Fang , Liu Jian , Xie Bei‐Bei 
Published: May 2019

AbstractCervical cancer (CC) is a common gynecological cancer and a leading cause of cancer‐related deaths in women globally. Therefore, this study explores the action of microRNA‐205 (miR‐205) in the invasion, migration, and angiogenesis of CC through binding to tumor suppressor lung cancer 1 (TSLC1). Initially, the microarray analysis was used to select the candidate gene and the regulatory microRNA. Then, the target relationship between miR‐205 and TSLC1 as well as the expression of miR‐205, TSLC1, and p‐Akt/total Akt in CC cells were determined. Afterwards, CC cell invasion and migration were detected after the treatment of miR‐205 mimics/inhibitors and short hairpin RNA against TSLC1. After coculture of cancer cells and vascular endothelial cells, cell proliferation, tube formation, and microvessel density (MVD) were detected to determine the roles of miR‐205 in angiogenesis. Finally, tumor growth in nude mice was measured in vivo. TSLC1 was determined as the candidate gene, which was found to be targeted and negatively regulated by miR‐205. Then, downregulated miR‐205 or forced TSLC1 expression inhibited invasion, migration, and angiogenesis in CC, corresponding to suppressed cell proliferation, tube formation, and expression of IL‐8, VEGF, and bFGF, as well as the inhibited activation of the Akt signaling pathway. Furthermore, downregulation of miR‐205 was found to exert an inhibitory role in tumor formation and MVD by elevating TSLC1 in CC in vivo. This study demonstrated that downregulated miR‐205 inhibited cell invasion, migration, and angiogenesis in CC by inactivating the Akt signaling pathway via TSLC1 upregulation.
Nasal or throat sampling is adequate for the detection of the human respiratory syncytial virus in children with acute respiratory infections
Authors: Nguyen Van Hoan , Russell Fiona M , Dance David AB , Vilivong Keoudomphone , Phommachan Souphatsone , Syladeth Chanthaphone , Lai Jana , Lim Ruth , Morpeth Melinda , Mayxay Mayfong , Newton Paul N , De Lamballerie Xavier , Dubot‐Pérès Audrey 
Published: May 2019

AbstractHuman respiratory syncytial virus (HRSV) is one of the most important causes of acute respiratory infections (ARI) in young children. HRSV diagnosis is based on the detection of the virus in respiratory specimens. Nasopharyngeal swabbing is considered the preferred method of sampling, although there is limited evidence of the superiority of nasopharyngeal swabs (NPS) over the less invasive nasal (NS) and throat (TS) swabs for virus detection by real‐time reverse transcription quantitative polymerase chain reaction (RT‐qPCR). In the current study, we compared the three swabbing methods for the detection of HRSV by RT‐qPCR in children hospitalized with ARI at Mahosot Hospital, Vientiane, Laos. In 2014, NS, NPS, and TS were collected from 288 children. All three samples were tested for HRSV by RT‐qPCR; 141 patients were found positive for at least one sample. Almost perfect agreements (κ > 0.8) between the swabs, compared two by two, were observed. Detection rates for the three swabs (between 93% and 95%) were not significantly different, regardless of the clinical presentation. Our findings suggest that the uncomfortable and technically more demanding NPS method is not mandatory for HRSV detection by RT‐qPCR.
Simulation modeling and interface parameter design of the semi‐physical braking intelligent test system
Authors: Ying Zhi Ding , Wan Guo Chun , Liu Wen Jing , Tong Mei Song 
Published: May 2019

AbstractIn order to adapt to the improvement of freight train braking technology, it is a good method to establish a semi‐physical braking intelligent test system, and the core technology of modeling and interface that supports the system is especially critical. Based on the above background, this paper is focus on the simulation modeling that reflects the braking performance characteristics of freight trains and designs the interface system that can be connected with the test equipment. Based on the analysis of the state equations of pressure gas during the braking process and the characteristics of fluid changes, this paper deduces a modular digital model of the braking machine that reflects the structural factors and the influencing factors of the process of fluid transfer. Then it combines the specific braking tests to verify the significance of the model and the effect of parameter changes on braking performance. The experimental results show the accuracy and feasibility of the modeling process, which provides a reference model establishing method and a research idea for the establishment of a more completed set of freight train braking system mathematical model. The design and implementation of this part of the technology also provide an important basis for the control part of the entire semi‐physical braking intelligent test system.
The “protected” glucose transport through the astrocytic endoplasmic reticulum is too slow to serve as a quantitatively‐important highway for nutrient delivery
Authors: Dienel Gerald A. 
Published: May 2019

AbstractA novel mechanism involving “protected glucose trafficking” through the lumen of the astrocytic endoplasmic reticulum (ER) was proposed by Müller et al. (Current Biology 28:3481, 2018) and highlighted by Pellerin (Current Biology 28:R1258, 2018) as a potential route for astrocyte‐neuron lactate shuttling. In their model, glucose is taken up from blood into astrocytic endfeet, phosphorylated, and some glucose‐6‐phosphate (Glc‐6‐P) is transported into the ER lumen where it is hydrolyzed by glucose‐6‐phosphatase‐β to produce glucose. The glucose then diffuses within the ER lumen through peripheral astrocytic processes (PAPs) to regions in close proximity to synapses where it is released to cytoplasm and metabolized to lactate and neurotransmitter precursors that can be shuttled to neurons. Experimental evidence supports aspects of this model, but essential components were not established. This commentary critically evaluates the Müller et al. study and discusses its weaknesses and intriguing aspects. Most important, the rate‐limiting step of the ER “protected highway,” transport of Glc‐6‐P into the ER, is extremely slow, on the order of 550‐3,700 times lower than glucose consumption by differentiated cultured astrocytes. Glucose diffusion through extracellular space to fuel neurons was not ruled out as an alternative mechanism. The ER glucose probes were not calibrated, and the ER luminal glucose reservoir size and flux of glucose through the ER are unknown. Effects of phosphatase knockdown are quite interesting and require further study. Glucose transport through a “protected intracellular highway” in the ER lumen is not quantitatively relevant to astrocytic glucose metabolism and is not energetically important.
Effect of ultrasonic and ball‐milling treatment on cell wall, nutrients, and antioxidant capacity of rose (Rosa rugosa) bee pollen, and identification of bioactive components
Authors: Yang Yang , Zhang Jiu‐liang , Zhou Qing , Wang Lin , Huang Wei , Wang Rui‐dan 
Published: May 2019

AbstractBACKGROUNDBee pollen has been regarded as a complete nutritional human dietary supplement but its nutrient absorption and biological effects may be restricted by the complex pollen wall. The aim of this study was to explore the effects of ultrasonic and ball‐milling treatment on the release of nutritional components and on in vitro and in vivo antioxidant effects of rose (Rosa rugosa) bee pollen.RESULTSBee pollen walls were broken to varying degrees, nutrients were released, and in vitro and in vivo antioxidant effects of bee pollen were improved. The scavenging effects of 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2′‐azinobis(3‐ethylbenzothiazolone‐6‐sulfonic acid) (ABTS) radicals, and oxygen radical absorbance capacity (ORAC) were improved. In aging mice, wall‐breaking treatment led to better organ recovery, enhanced superoxide dismutase (SOD) and catalase (CAT) effects, and malondialdehyde (MDA) reduction. Eight compounds of rose bee pollen ethanol extract, including isorhamnetin 3‐O‐diglucoside and N′, N″, N‴‐dicaffeoyl p‐coumaroyl spermidine were identified by ultra‐performance liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (UPLC‐ESI‐QTOF‐MS/MS) assay.CONCLUSIONThis study showed that ultrasonic treatment had greater wall‐disruption effects of bee pollen on nutrient release and antioxidant effect promotion. In conclusion, rose bee pollen, with wall‐breaking treatments, may have potential value as an ingredient in functional food processing. © 2019 Society of Chemical Industry
Thermochemistry and kinetics of the 2‐butanone‐4‐yl CH3C(=O)CH2CH2• + O2 reaction system
Authors: Sebbar N. , Bozzelli J. W. , Trimis D. , Bockhorn H. 
Published: May 2019

AbstractThermochemistry and kinetic pathways on the 2‐butanone‐4‐yl (CH3C(=O)CH2CH2•) + O2 reaction system are determined. Standard enthalpies, entropies, and heat capacities are evaluated using the G3MP2B3, G3, G3MP3, CBS‐QB3 ab initio methods, and the B3LYP/6‐311g(d,p) density functional calculation method. The CH3C(=O)CH2CH2• radical + O2 association reaction forms a chemically activated peroxy radical with 35 kcal mol−1 excess of energy. The chemically activated adduct can undergo RO−O bond dissociation, rearrangement via intramolecular hydrogen transfer reactions to form hydroperoxide‐alkyl radicals, or eliminate HO2 and OH. The hydroperoxide‐alkyl radical intermediates can undergo further reactions forming ketones, cyclic ethers, OH radicals, ketene, formaldehyde, or oxiranes. A relatively new path showing a low barrier and resulting in reactive product sets involves peroxy radical attack on a carbonyl carbon atom in a cyclic transition state structure. It is shown to be important in ketones when the cyclic transition state has five or more central atoms.
Total intravenous versus inhalational anesthesia in endoscopic sinus surgery: A meta‐analysis
Authors: Lu Victor M. , Phan Kevin , Oh Lawrence J. 
Published: May 2019

ObjectiveAchieving optimal intraoperative surgical field visibility and minimizing blood loss are two important parameters in endoscopic sinus surgery (ESS). The aim of this meta‐analysis was to compare two total intravenous anesthesia (TIVA) and inhalational anesthesia (IA) to determine if either conferred superior outcomes of these and other parameters based on randomized control trials (RCTs) only.MethodsThe recommended Preferred Reporting Items for Systematic reviews and Meta‐Analyses guidelines were followed, and searches of electronic databases from inception to September 2018 identified 157 articles for screening. Data were extracted and analyzed using meta‐analysis of proportions.ResultsIn total, we identified 15 RCTs that satisfied our selection criteria. There were 828 ESS cases described, with 391 (47%) and 437 (53%) being managed by TIVA and IA, respectively. Pooled analysis demonstrated significantly superior visibility scores for TIVA compared to IA based on 10‐point grading scores (P = 0.049, visual analog scale; P = 0.009, Wormald scale) and 5‐point grading scores (P = 0.002, Boezaart scale). Blood loss was significantly less following TIVA (P = 0.003), with no significant difference in intraoperative heart rate (P = 0.70) or mean arterial pressure (P = 0.96). Additionally, duration of surgery (P = 0.16) and anesthesia (P = 0.39) were comparable between the two approaches.ConclusionThis meta‐analysis indicates that TIVA has the potential to confer superior surgical field visibility and reduce intraoperative blood loss compared to IA in ESS. Currently, there are significant heterogeneity concerns in this meta‐analysis, which temper any expectations that either approach is absolutely superior to the other. Caution should be exercised when interpreting these results until further validation can be achieved.Level of Evidence1ALaryngoscope, 130:575–583, 2020
Molecular Mechanism Study on Effect of Biodegradable Amino Acid Ester–Substituted Polyphosphazenes in Stimulating Osteogenic Differentiation
Authors: Huang Zhaohui , Yang Lika , Hu Xiaoqing , Huang Yiqian , Cai Qing , Ao Yingfang , Yang Xiaoping 
Published: May 2019

AbstractAmino acid ester substituted polyphosphazenes are osteoactive benefiting from their phosphorus‐containing chemical structure, which highlights interests in bone tissue engineering. To correlate their chemical structures with cell activities, in this study, poly[(ethyl alanato)0.3(ethyl glycinato)0.7phosphazene] (PAGP) and poly[(ethyl phenylalanato)0.3(ethyl glycinato)0.7phosphazene] (PPGP) are synthesized to carry out studies on cell osteogenic differentiation. In the non‐contact culture manner, bone mesenchymal stromal cells (BMSCs) are cultured in transwell chambers containing PAGP or PPGP films, while the cells and the materials do not contact. In the contact culture manner, BMSCs are cultured on the PAGP or PPGP films. In the meantime, solutions containing PAGP or PPGP degradation products (i.e., phosphate, ammonium, and corresponding amino acids) are applied for cell culture using inorganic phosphate (Pi) ion as control. Thus, the influences from substrate surface and degradation products can be identified separately. The results reveal that both the phosphorus‐containing surface of PAGP and PPGP films and their degradation products play significant roles in regulating cell behaviors. In comparison with PAGP, PPGP seems able to provide relatively stable phosphorus‐containing surface to strengthen the cell‐scaffold interaction because of its slower degradation rate and higher Young's modulus, leading to greater promotion in osteogenic differentiation via contact effect.
Compact low‐temperature co‐fired ceramic filtering antenna array with high selectivity exploiting substrate integrated waveguide for 5G
Authors: Zhang Xiangjun , Yan Jia , Zhang Hao , Chen Yiming 
Published: May 2019

AbstractIn this study, a compact filtering 2 × 2 array antenna with high selectivity utilizing substrate integrated waveguide (SIW) is presented. The proposed antenna structure is mainly composed of coplanar waveguide feeding structures, SIW filtering cavities, and four radiation patches by low‐temperature co‐fired ceramic technology. The designed antenna not only achieves the advantages of high selectivity but also realizes a miniaturized volume of 12 × 12 × 1.18 mm3. The simulated and measured results show that the filtering antenna achieves a center frequency of 28 GHz and has a 10.7% fractional bandwidth with a 10.8 dB antenna gain.
Remote afterloading patient‐specific brachytherapy with liquid radioisotope for irradiation of extensive scalp lesions: A Monte Carlo study
Authors: Ryu Dongmin , Kim Jung‐in , Lee Sangmin , Ye Sung‐Joon , Park Jong Min 
Published: May 2019

PurposeThe aim of this study is to propose a remote afterloading patient‐specific brachytherapy technique for total scalp irradiation by utilizing liquid radioisotope as well as a three‐dimensional (3D) printer and to find an optimal radioisotope for the suggested technique.MethodsWe designed a brachytherapy device composed of liquid radioisotope tank, tube, patient‐specific applicator, and a thin flexible pouch. The liquid radioisotope tank, tube, and the flexible pouch are interconnected one another to constitute a closed loop system. The pouch is located inside the solid patient‐specific applicator; therefore, when the liquid radioisotope is injected into the pouch, the pouch is inflated and fills the space inside the applicator. The 3D‐printed patient‐specific applicator keeps the uniform thickness of the liquid radioisotope conforming patient's contour. To investigate an optimum condition for the suggested system, we performed Monte Carlo simulation with the GEANT4 simulation toolkit. To find the optimal radioisotope, percent depth doses (PDDs) of P‐32, Sr‐89, Y‐90, and I‐125 solutions were acquired in a rectangular parallelepiped phantom. For the selected radiation source, PDDs as well as dose rates in spherical phantoms with radii of 7.7 cm (infant head size) and 9.1 cm (adult head size) were acquired.ResultsTo deliver prescription doses at 4‐mm depth regions (scalp region), 1‐mm‐thick Y‐90 and 5‐mm‐thick I‐125 in liquid form were found to be feasible for the suggested technique. For both spherical phantoms with radii of 7.7 and 9.1 cm, when delivering 2 Gy at the 4‐mm depth region with the 1‐mm‐thick Y‐90 and 5‐mm‐thick I‐125 sources, 53.3 and 3.8 Gy were delivered at the surface regions, respectively (delivery time = 111.1 and 3.5 min with 1 GBq/ml solutions). The PDDs of Y‐90 and I‐125 became less than 1% at depths greater than 8 and 50 mm, respectively.ConclusionsThe remote afterloading patient‐patient specific brachytherapy with I‐125 or Y‐90 in liquid form seems feasible for total scalp irradiation.
Advances in HDR Display Technology for Cinema Applications, Including Light‐Steering Projection
Authors: Ballestad Anders , Boitard Ronan , Damberg Gerwin , Stojmenovik Goran 
Published: May 2019

AbstractCinematic display solutions are catching up with consumer display technologies' capabilities in both brightness and contrast. However, a mainstream rollout of HDR in cinema requires a high‐performing and cost‐effective solution. In this article, the first of a two‐part series, the authors review solutions being developed and performance specifications suggested for HDR on the big screen.
Surgery for female SUI: The ICI algorithm
Authors: Kowalik Casey G. , Dmochowski Roger R. , De Elise J. B. 
Published: May 2019

IntroductionStress urinary incontinence (SUI) is common in women and can significantly impact quality of life.MethodsThis is a review of the 6th International Consultation on Incontinence (ICI) chapter analyzing level of evidence on surgical treatment of SUI as well as the consensus algorithm that resulted from the detailed work in the committee report as of April 2017. Included studies in this review were selected to highlight the algorithm for management.ResultsNon‐operative and surgical treatment options exist; conservative therapies comprise first line management, but if SUI remains bothersome, surgical treatment should be considered. Bulking agents offer a minimally invasive option with moderate short‐term success rates. The most commonly performed surgical treatments for SUI are mid‐urethral and pubovaginal slings, with high cure rates and patient satisfaction. Retropubic suspension is a more traditional but widely accepted procedure. Single incision sling, adjustable sling, or artificial urinary sphincter may be appropriate in carefully selected patients.ConclusionsThe choice of surgical procedure should be made only after a thorough discussion and shared decision between the patient and surgeon regarding risks, benefits, and alternatives. A trial of conservative therapy should be conducted where relevant. Referral to a specialist should be considered in women with a more complex presentation.
Optimal control of second‐order and high‐order descriptor systems
Authors: Zhang Liping , Zhang Guoshan , Liu Wanquan 
Published: May 2019

SummaryThis study investigates the optimal control problem of second‐order descriptor systems. The optimal control is characterized by using a new second‐order generalized Riccati equation, which is directly derived in terms of the original coefficient matrices of the system. Under some assumption conditions, applying matrix's singular value decomposition and matrix transformation, a nonlinear generalized Riccati matrix equation is transformed into a linear matrix equation, and the optimal control gain can be determined by solving the linear matrix equation. Furthermore, relevant results are also extended to the optimal control problems for the high‐order descriptor system. Finally, several simulation examples and the comparison with the existing linearization method are provided to illustrate the effectiveness of the developed approach.
Severe therapy‐related toxicities after treatment for Hodgkin lymphoma due to a pathogenic TERT variant and shortened telomeres
Authors: Agrusa Jennifer E. , Bertuch Alison A. , DiNardo Courtney D. , Plon Sharon E. , Eckstein Olive S. 
Published: May 2019

AbstractTelomere biology disorders predispose affected individuals to specific malignancies and organ fibrosis in tissues sensitive to telomere length (TL) shortening, especially after exposure to chemotherapy and radiation. We report a case of a 17‐year‐old female with Hodgkin lymphoma who developed severe chemotherapy‐related toxicities. She was subsequently found to have peripheral blood lymphocyte TL < 1st percentile and a pathogenic variant in TERT inherited from her father. This case demonstrates that early genetic evaluation of patients who experience greater than expected therapy‐related toxicities may be warranted to help guide further decisions regarding therapy, imaging modalities, and lifelong cancer prevention surveillance.