bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of novel therapeutic targets for neuropathic pain based on gene expression patterns
Authors: Zhu Di , Liu Kang , Wan Cheng‐Liang , Lu Jangnin , Zhao Hong‐Xia 
Published: June 2019

AbstractNeuropathic pain (NP) caused by nerve injury or dysfunction is one of the most challenging neurological diseases. In‐depth study of disease signatures contributes to the development of novel target treatment for NP. In this study, we analyzed expression profiles of qualified NP datasets (GSE24982 and GSE63442) deposited at Gene Expression Omnibus database by systematic bioinformatics approaches. We analyzed the differentially expressed genes of high and low pain compared with normal control group, and between spinal nerve ligation (SNL) injury model and sham‐operation group. A total of 1,243 upregulated and 1,533 downregulated genes were identified in GSE24982, 380 upregulated and 355 downregulated genes were identified in GSE63442. By comparing low‐pain samples with the corresponding sham‐operation group, we identified 457 upregulated and 409 downregulated genes. Overlapping genes were screened out and signaling pathway and expression regulation model analyses were performed. SCN10A and SST were identified as biomarkers for NP. In conclusion, our study showed the expression pattern of gene about NP. These identified biomarkers could serve as potential therapeutic targets for treating NP.
Implications of resistin in type 2 diabetes mellitus and coronary artery disease: Impairing insulin function and inducing pro‐inflammatory cytokines
Authors: Emamalipour Melissa , Seidi Khaled , Jahanban‐Esfahlan Ali , Jahanban‐Esfahlan Rana 
Published: June 2019

AbstractDiabetes mellitus is a metabolic and chronic disorder, which is very common all over the world. Many genetic and nongenetic factors are involved in the development of type 2 diabetes mellitus (T2DM). Meanwhile, the resistin gene is an important candidate in the pathogenesis of this complex condition. High levels of transcription of the resistin gene are associated with inflammation, insulin resistance, initiation and development of T2DM and atherosclerosis progression through induction of secretion of bioactive materials from adipocytes. Releasing adipose tissue‐derived inflammatory cytokines is associated with inflammatory processes activation, which causes inhibition of insulin action via interference with insulin signaling, such that these disorders can contribute to insulin resistance. With the direct effect of resistin and other inflammatory mediators on vascular endothelial cells and arterial walls, the expression of cell adhesion molecules is increased. This process can lead to atherosclerosis and will result in coronary artery disease (CAD). In this review, we will explore the effects of resistin on inflammation and insulin resistance that may lead to type 2 diabetes and CAD.
Postinfarction exercise training alleviates cardiac dysfunction and adverse remodeling via mitochondrial biogenesis and SIRT1/PGC‐1α/PI3K/Akt signaling
Authors: Jia Dandan , Hou Lu , Lv Yongzhi , Xi Lei , Tian Zhenjun 
Published: June 2019

AbstractExercise training mitigates cardiac pathological remodeling and dysfunction caused by myocardial infarction (MI), but its underlying cellular and molecular mechanisms remain elusive. Our present study in an in vivo rat model of MI determined the impact of post‐MI exercise training on myocardial fibrosis, mitochondrial biogenesis, antioxidant capacity, and ventricular function. Adult male rats were randomized into: (a) Sedentary control group; (b) 4‐week treadmill exercise training group; (c) Sham surgery group; (d) MI group with permanent ligation of left anterior descending coronary artery and kept sedentary during post‐MI period; and (e) post‐MI 4‐week exercise training group. Results indicated that exercise training significantly improved post‐MI left ventricular function and reduced markers of cardiac fibrosis. Exercise training also significantly attenuated MI‐induced mitochondrial damage and oxidative stress, which were associated with enhanced antioxidant enzyme expression and/or activity and total antioxidant capacity in the heart. Interestingly, the adaptive activation of the SIRT1/PGC‐1α/PI3K/Akt signaling following MI was further enhanced by post‐MI exercise training, which is likely responsible for exercise‐induced cardioprotection and mitochondrial biogenesis. In conclusion, this study has provided novel evidence on the activation of SIRT1/PGC‐1α/PI3K/Akt pathway, which may mediate exercise‐induced cardioprotection through reduction of cardiac fibrosis and oxidative stress, as well as improvement of mitochondrial integrity and biogenesis in post‐MI myocardium.
Evaluation of the Safety of Rapid Parenteral Nutrition Titration
Authors: Curry Dominick , Giancarelli Amanda , Vickers Donald C. 
Published: June 2019

AbstractBackgroundInitiation of parenteral nutrition (PN) can cause complications including hyperglycemia (HGL), electrolyte abnormalities, and refeeding syndrome (RFS). These concerns lead many to titrate over several days, but our practice is to titrate PN to goal within 8 hours. The aim of this study was to evaluate the safety of titrating PN to goal within 8 hours.MethodsThis was a single‐center, retrospective study of adult patients initiated on continuous PN with titration to goal rate in <8 hours. The primary composite outcome included the incidence of HGL, hypomagnesemia, hypophosphatemia, or hypokalemia within 24 hours of PN initiation. Secondary outcomes included analyses of patients with risk factors for HGL and RFS, critically ill patients, and individual components of the composite outcome.ResultsThree hundred forty‐two patients were included, with a primary outcome incidence of 24.6% (HGL 17.4%; hypokalemia 1.8%; hypomagnesemia 0.6%; hypophosphatemia 8.5%). The primary outcome was more common in the HGL group (34.3% vs 14.7%, P < 0.01) and in the ICU group (40.9% vs 20.7%, P < 0.01). Mean 24‐hour blood glucose > 180 mg/dL occurred more in the HGL group (27.9% vs 7.6%, P < 0.01) and in the ICU group (34.8% vs 13.8%, P < 0.01). In patients with no risk factors, the primary outcome was 11.9%.ConclusionRapid PN titration was likely safe in patients without risk factors for HGL or RFS. Further evaluation of protocolized HGL management is needed to determine the risk of HGL in patients with HGL risk factors.
Histological subtype remains a prognostic factor for survival in nasopharyngeal carcinoma patients
Authors: Pan Xing‐Xi , Liu Ya‐Jie , Yang Wen , Chen Yong‐Fa , Tang Wu‐Bing , Li Chu‐Rong 
Published: June 2019

ObjectivesThere is currently no consensus on the prognostic significance of the histological subtype of nasopharyngeal carcinoma (NPC). The aim of the current study was to evaluate the impact of histological subtype on survival in NPC patients based on the Surveillance, Epidemiology, and End Results (SEER) Program.MethodsPatients with NPC were identified within the SEER database (2004–2015). The effects of histological subtype on cause‐specific survival (CSS) in NPC patients were evaluated using univariate and multivariate Cox regression analyses. Subgroup analysis according to histological subtype in NPC patients was carried out by 1:1 propensity score matching (PSM).ResultsA total of 4085 NPC patients were selected from the SEER database, including 1929 with keratinizing squamous cell carcinoma (KSCC), 2203 with nonkeratinizing carcinoma (NKC), and 53 with basaloid squamous cell carcinoma (BSCC). The 3‐year and 5‐year CSS rates were 61.76% and 55.07% for KSCC patients, 79.57% and 72.09% for NKC patients, and 77.55% and 74.03% for BSCC patients, respectively. Multivariate analysis identified sex, age, marital status, race, T stage, N stage, M stage, radiotherapy, chemotherapy, and histological subtype as significant prognostic factors for CSS in NPC patients. KSCC was found to be associated with worse CSS than NKC on Kaplan‐Meier analysis and subgroup analysis after 1:1 PSM.ConclusionsHistological subtype determines the long‐term survival outcomes of patients with NPC. Moreover, the NKC subtype has the best prognosis, while the KSCC subtype has the worst prognosis.Level of EvidenceNALaryngoscope, 130:E83–E88, 2020
PTEN Is Associated With Worse Local Control in Early Stage Supraglottic Laryngeal Cancer Treated With Radiotherapy
Authors: Bruine de Bruin Leonie , Wachters Jan E. , Schrijvers Michiel L. , Slagter‐Menkema Lorian , Mastik Mirjam F. , Langendijk Johannes A. , van der Wal Jacqueline E. , Schuuring Ed , van der Laan Bernard F. A. M. 
Published: June 2019

ObjectivesThe aim of this study was to establish the prognostic value of the epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression on local control in patients with early stage supraglottic laryngeal squamous cell carcinoma (LSCC) treated with radiotherapy only.Study designRetrospective cohort study.MethodsImmunohistochemical staining for EGFR and PTEN was performed on pretreatment biopsies of a selected well‐defined homogeneous group of 52 patients with T1–T2 supraglottic LSCC treated with radiotherapy between 1990 and 2008. Kaplan–Meier analysis and univariate and multivariate Cox Regression analyses were performed to correlate clinical data and expression levels of EGFR and PTEN with local control.ResultsKaplan–Meier survival analysis and Cox Regression analysis showed a significant association between PTEN expression and local control (hazard ratio [HR] = 3.26, 95% confidence interval [CI] = 1.14–9.33, P = .027) and between lymph node status and local control (HR = 3.60, 95% CI = 1.26–10.31, P = .017). Both were independent prognostic factors in a multivariate analysis (HR = 3.28, 95% CI = 1.14–9.39, P = .027 and HR = 3.62, 95% CI = 1.26–10.37, P = .017, respectively). There was no significant association between EGFR expression and local control (HR = 1.32, 95% CI = 1.17–10.14, P = .79).ConclusionThis study showed an association between both high PTEN expression and the presence of lymph node metastasis and deteriorated local control in early stage supraglottic LSCC treated with radiotherapy.Level of EvidenceNA
Experimental Design and Statistical Analysis of AGET ATRP of MMA in Emulsion Polymer Reactor
Authors: Upadhayay Regmi Kishor N. , Mehrvar Mehrab , Dhib Ramdhane 
Published: June 2019

AbstractThis study investigates atom transfer radical polymerization (ATRP) of methyl methacrylate (MMA) using activators generated by electron transfer (AGET) as the initiation technique in an emulsion well‐mixed 2L stirred tank reactor. The performance of the AGET ATRP of MMA is analyzed for five key independent variables, namely temperature, catalyst complex (CuBr2/dNbpy), initiator (EBiB), reducing agent (ascorbic acid), and surfactant (Brij 98). The reaction is carried out based on a two‐step polymerization procedure. A resolution 5 fractional factorial design technique is employed to assess the influence of the five independent variables on the monomer conversion, polymer average molecular weights, and polydispersity index (PDI). An input–output model is constructed from the data of 21 designed experimental tests. A statistical analysis of the results shows that the temperature is the most influential variable for the three output process responses. The initiator strongly affects the poly(methyl methacrylate) (PMMA) molecular weights. It is the least important key variable affecting MMA conversion and PDI, and the surfactant is the least one affecting PMMA Mn. On assessing the independent interactions effect, the interactions of temperature‐surfactant on conversion, and temperature‐initiator for PMMA Mn are considered. Process simulation in 3D mapping has demonstrated that model predictions agree well with experimental data.
Behavioral therapy for urinary symptoms in Parkinson's disease: A randomized clinical trial
Authors: Vaughan Camille P. , Burgio Kathryn. L. , Goode Patricia S. , Juncos Jorge L. , McGwin Gerald , Muirhead Lisa , Markland Alayne D. , Johnson Theodore M. 
Published: June 2019

AbstractAimDetermine the efficacy of behavioral therapy for urinary symptoms in Parkinson's disease.MethodsRandomized trial of behavioral therapy compared with control condition among adults (aged 54‐85 years, 74% male, 10% Black/ 83% White) with Parkinson's and greater than or equal to 4 incontinence episodes weekly. Behavioral therapy included pelvic floor muscle exercises, bladder training, fluid and constipation management. Both groups completed bladder diary self‐monitoring. Outcomes included diary‐derived incontinence and ICIQ‐overactive bladder (OAB) score (range, 0‐16) with bother and quality of life questionnaires (higher scores = worse outcomes).ResultsFifty‐three participants randomized and 47 reported 8‐week outcomes including 26 behavioral therapy and 21 control. Behavioral vs control participants were similar with respect to age (71.0 ± 6.1 vs 69.7 ± 8.2 years), sex (70% vs 78% male), motor score, cognition, mean weekly incontinence episodes (13.9 ± 9.6 vs 15.1 ± 11.1) and OAB symptoms (8.9 ± 2.4 vs 8.3 ± 2.2). Weekly incontinence reduction was similar between behavioral (−6.2 ± 8.7) and control participants (−6.5 ± 13.8) (P = 0.89). After multiple imputation analysis, behavioral therapy participants reported statistically similar reduction in OAB symptoms compared to control (−3.1 ± 2.8 vs −1.9 ± 2.2, P = 0.19); however quality of life (−22.6 ± 19.1 vs −7.0 ± 18.4, P = 0.048) and bother (−12.6 ± 17.2 vs − 6.7 ± 8.8, P = 0.037) improved significantly more with behavioral therapy.ConclusionSelf‐monitoring resulted in fewer urinary symptoms; however, only multicomponent behavioral therapy was associated with reduced bother and improved quality of life. Providers should consider behavioral therapy as initial treatment for urinary symptoms in Parkinson's disease.
Effect of a care process programme on frail older people’s life satisfaction
Authors: Berglund Helene , Gustafsson Susanne , Ottenvall Hammar Isabelle , Faronbi Joel , Dahlin‐Ivanoff Synneve 
Published: June 2019

AbstractAimThe aim of this study was to analyse the effects of a full‐scale implementation of a care process programme on life satisfaction among frail older people, as compared with those receiving usual care.DesignThe study includes participants from a full‐scale care process programme (N = 77) and participants from a historical control group (N = 66). The care process programme establishes a comprehensive continuum of care through components including case management, interprofessional teamwork and care‐planning meetings in the older people's own homes.MethodsQuestionnaires were used and data were collected at baseline, with follow‐ups at three, six and 12 months.ResultsThe implementation of the full‐scale care process programme had a positive effect on life satisfaction among frail older people. From 6‐month–12‐month follow‐ups, a higher proportion of participants in the care process programme had positive life satisfaction outcomes, as compared with the historical control group.
Wishes and needs of older persons who have experienced a fall: A qualitative study
Authors: Bertelsen Ann Sophia , Ryg Jesper , Masud Tahir , Nielsen Dorthe S. 
Published: June 2019

AbstractAimThe aim of this study was to explore the needs and wishes in everyday life of older persons who have experienced a fall.DesignA hermeneutic‐phenomenological design with semi‐structured interviews.MethodInterviews were analysed using systematic text condensation.ResultsNine patients (5 women, 4 men) were included. The participants were between 67–95 years old. Seven of the nine participants had suffered from recurrent falls. The analysis revealed four themes: “To maintain meaningfulness in everyday life after experiencing a fall”, “Contact with professionals can be a prerequisite for feeling well and motivated after a fall”, “A need for assistive technology and aids in everyday life” and “Asking for help can be a challenge”. Our findings highlight that older‐person‐centred care and treatment are essential to address the complex variations in needs and wishes of older persons who have experienced a fall.
Oncogenic mutations in histologically normal endometrium: the new normal?
Authors: Lac Vivian , Nazeran Tayyebeh M , Tessier‐Cloutier Basile , Aguirre‐Hernandez Rosalia , Albert Arianne , Lum Amy , Khattra Jaswinder , Praetorius Teresa , Mason Madeline , Chiu Derek , Köbel Martin , Yong Paul J , Gilks Blake C , Anglesio Michael S , Huntsman David G 
Published: June 2019

AbstractThe advent of next generation sequencing has vastly improved the resolution of mutation detection, thereby both increasing the resolution of the analysis of cancer tissues and shining light on the existence of somatic driver mutations in normal tissues, even in the absence of cancer. Studies have described somatic driver mutations in normal skin, blood, peritoneal washings, and esophageal epithelium. Such findings prompt speculation on whether such mutations exist in other tissues, such as the eutopic endometrium in particular, due to the highly regenerative nature of the endometrium and the recent observation of recurrent somatic driver mutations in deep infiltrating and iatrogenic endometriosis (tissues believed to be derived from the eutopic endometrium) by our group and others. In the current study we investigated the presence of somatic driver mutations in histologically normal endometrium from women lacking evidence of gynecologic malignancy or endometrial hyperplasia. Twenty‐five women who underwent hysterectomies and 85 women who underwent endometrial biopsies were included in this study. Formalin‐fixed, paraffin‐embedded tissue specimens were analyzed by means of targeted sequencing followed by orthogonal validation with droplet digital PCR. PTEN and ARID1A immunohistochemistry (IHC) was also performed as surrogates for inactivating mutations in the respective genes. Overall, we observed somatic driver‐like events in over 50% of normal endometrial samples analyzed, including hotspot mutations in KRAS, PIK3CA, and FGFR2 as well as PTEN‐loss by IHC. Analysis of anterior and posterior samplings collected from women who underwent hysterectomies was consistent with the presence of somatic driver mutations within clonal pockets spread throughout the uterus. The prevalence of such oncogenic mutations also increased with age (OR: 1.05 [95% CI: 1.00–1.10], p = 0.035). These findings have implications on our understanding of aging and so‐called ‘normal tissues’, thereby necessitating caution in the utilization of mutation‐based early detection tools for endometrial or other cancers. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
A lightweight, strength and electromagnetic shielding polymer composite structure for infant carrier strollers
Authors: Dogan Sonay , Kayacan Ozan , Goren Aytac 
Published: June 2019

AbstractElectromagnetic (EM) shielding is a protection about reducing the EM fields in a space by blocking the waves with barriers including conductive materials. EM shielding has become an important concept in recent years as a result of increased EM environment pollution. Its long‐term effects are still being investigated in terms of public health. Because of gaining more and more importance in daily life, there are a large number of research subjects including not only raw materials but also end‐products in the literature. In this study, EM shielding characteristics and strength analysis of a diverse range of polymer composites were evaluated and compared for use in an infant carrier stroller body. This type of strollers is not only used for carrying infants, but also some parts of them are used as baby car seats which should be light and strength. Since, the strollers are commonly used in public areas which the infant is exposed to EM radiation and it is strongly recommended to protect infants from EM radiation, sample polymer composite plates have been produced and electromagnetic shielding effectiveness (EMSE) measurements in an anechoic chamber were performed. According to EMSE performances of the plates in frequency range of 700 MHz to 3 GHz, two of the nine different (carbon, aramid, hybrid, glass fiber) textiles were selected to be used in two infant carrier prototypes. After production of prototypes, samples from these prototypes were taken, tensile and impact tests were performed to determine if the molded structures were strength and light enough.
Stability of Dihydroxylammonium 5,5’‐Bistetrazole‐1,1’‐Diolate (TKX‐50) in Solvents
Authors: Jia Jianhui , Xu Jinjiang , Cao Xiong , Li Shichun , Huang Shiliang , Liu Yu , Li Jinshan 
Published: June 2019

AbstractThe stability of solid TKX‐50 has attracted considerable attention. However, the stability of TKX‐50 in solvents has not been investigated sufficiently yet. Herein, the stability of TKX‐50 in various solvents, including N, N‐dimethylformamide (DMF), dimethyl sulfoxide (DMSO), acetone, deionized water, ethyl acetate, acetonitrile, methanol, ethanol, petroleum ether, hexane, DMF/acetone (mixture of DMF and acetone) and DMF/DMSO (mixture of DMF and DMSO), has been studied. The results show that TKX‐50 remains stable in DMSO, deionized water, ethyl acetate, acetonitrile, methanol, ethanol, petroleum ether and hexane. It is remarkable that TKX‐50 can react with DMF in different ways under different conditions, such as a wide temperature range from 25 °C to 150 °C. The products in reactions between TKX‐50 and DMF were dimethylammonium 5, 5’‐bistetrazole‐1‐hydroxy‐1’‐oxygen (DMA‐BTO), dimethylamine 5, 5’‐bistetrazole‐1, 1’‐diolate (2DMA‐BTO) and diammonium 5,5’‐bistetrazole‐1,1’‐diolate (ABTOX), which were confirmed by single crystal diffraction, respectively. Moreover, the thermal stability of the products and the interconversion pathways between TKX‐50 and products were determined. Subsequently, the reaction mechanism of TKX‐50 in DMF solvent has been inferred.
CL‐20 Based Ultraviolet Curing Explosive Composite with High Performance
Authors: Guo Hao , Xu Shuai , Gao Huihui , Geng Xiaoheng , An Chongwei , Xu Chuanhao , Li Qianbing , Wang Shuang , Ye Baoyun , Wang Jingyu 
Published: June 2019

AbstractThe integration of the Ultraviolet (UV) curable resin into energetic materials, has been a new direction in the field of explosive inks with high curing speed and high solid loading. In this ink formulation, polyurethane acrylate (PUA), 2,4,6‐trimethylbenzoyl‐diphenylphosphine oxide (TPO) and hexanitrohexaazaisowurtzitane (CL‐20) were selected as binder, photoinitiator and main explosive, respectively. The CL‐20 based UV‐curing explosive composite was prepared by UV‐curing and direct ink writing (DIW) technology. The rate of curing, micro‐scale structure, morphology, crystal type, impact sensitivity, and detonation ability of the sample were characterized and analyzed. The results show that the curing process of CL‐20 based UV‐curing explosive ink could be completed within 7 minutes after UV‐curing for 3 minutes, revealing rapid curing speed. In the preparation process of CL‐20 based explosive composite, the crystal type of CL‐20 do not change. Compared with raw CL‐20, the explosive composite has a lower impact sensitivity. Moreover, the critical detonation size is around 1×0.078 mm, and the detonation velocity is 7357 m s−1.