bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Outcomes Following Treatment for Clubfoot
Authors: Jeans Kelly A. , Karol Lori A. , Erdman Ashley L. , Stevens Wilshaw R. 
Published: December 2018

Background:
The purpose of this study was to assess function, at the age of 10 years, of children initially treated nonoperatively for clubfoot with either the Ponseti or French physiotherapy program and to compare outcomes in feet that had undergone only nonoperative treatment with those that required subsequent surgery.

Methods:
Gait analysis, isokinetic ankle strength, parent-reported outcomes, and daily step activity data were collected when patients who had been treated for idiopathic clubfoot reached the age of 10 years. Patients who had undergone only nonoperative treatment were compared with those who subsequently underwent extra-articular surgery or intra-articular surgery (posterior release or posteromedial release). The clubfoot groups were compared with age-matched controls.

Results:
Of 263 treated clubfeet in 175 patients, 148 had only been treated nonoperatively, 29 underwent extra-articular surgery, and 86 underwent intra-articular surgery (posterior release in 42 and posteromedial release in 44). Significant abnormalities were found in ankle kinetics and isokinetic ankle strength in the feet treated with intra-articular surgery compared with the nonoperatively treated feet (p < 0.017). Compared with controls (n = 40 feet), all groups showed reduced ankle plantar flexion during gait, resulting in a deficit of 9% to 14% for dynamic range of motion, 13% to 20% for ankle moment, and 13% to 23% for power (p < 0.013). Within the intra-articular group, feet that underwent posteromedial release had decreased plantar flexion strength (15%; p = 0.008), dorsiflexion strength (6%; p = 0.048), and parent-reported global function scores (p = 0.032) compared with the posterior release group. The patients with clubfoot took 10% fewer steps (p = 0.015) and had 11% less total ambulatory time (p = 0.001) than the controls.

Conclusions:
Examination of patients when they had reached the age of 10 years showed better ankle power and isokinetic strength for clubfeet treated without surgery compared with those that underwent intra-articular surgery for residual deformity or recurrence. Compared with controls, both nonoperatively and surgically treated clubfeet had significant limitations in ankle plantar flexion resulting in decreased range of motion, moment, and power. Gastrocnemius-soleus complex strength was decreased after both nonoperative and surgical treatment of clubfeet. Although activity was diminished in the clubfoot population, no differences in function were perceived by the patients’ parents.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Outcomes of the Ponseti Method for Untreated Clubfeet in Nepalese Patients Seen Between the Ages of One and Five Years and Followed for at Least 10 Years
Authors: Banskota Bibek , Yadav Prakash , Rajbhandari Tarun , Shrestha O.P. , Talwar Divya , Banskota Ashok , Spiegel David A. 
Published: December 2018

Background:
To our knowledge, there are no reports of the Ponseti method initiated after walking age and with >10 years of follow-up. Our goal was to report the clinical findings and patient-reported outcomes for children with a previously untreated idiopathic clubfoot who were seen when they were between 1 and 5 years old, were treated with the Ponseti method, and had a minimum follow-up of 10 years.

Methods:
A retrospective review of medical records was supplemented by a follow-up evaluation of physical findings (alignment and range of motion) and patient-reported outcomes using the Oxford Ankle Foot Questionnaire for Children (OxAFQ-C). The initial treatment was graded as successful if a plantigrade foot was achieved without the need for an extensive soft-tissue release and/or osseous procedure.

Results:
We located 145 (91%) of 159 patients (220 clubfeet). The average age at treatment was 3 years (range, 1 to 5 years), and the average duration of follow-up was 11 years (range, 10 to 12 years). The initial scores according to the systems of Pirani et al. and Diméglio et al. averaged 5 and 17, respectively, and an average of 8 casts were required. Surgical treatment, most commonly a percutaneous Achilles tendon release (197 feet; 90%), was required in 96% of the feet. A plantigrade foot was achieved in 95% of the feet. Complete relapse was rare (3%), although residual deformities were common. Patient-reported outcomes were favorable.

Conclusions:
A plantigrade foot was achieved in 95% of the feet initially and was maintained in most of the patients, although residual deformities were common. Patient-reported outcomes were satisfactory, and longer-term follow-up with age-appropriate outcome measures will be required to evaluate function in adulthood.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial
Authors: Salman Rustam Al-Shahi , Murray Gordon D. , Dennis Martin S. , Newby David E. , Sandercock Peter A.G. , Sprigg Nikola , Sudlow Cathie L.M. , Werring David J. , White Philip M. , Whiteley William N. 
Published: December 2018

Abstract
Background: For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear whether starting antiplatelet drugs modifies the risks of recurrent ICH, haemorrhagic events, vaso-occlusive events, or a composite of all serious vascular events compared to avoiding antiplatelet drugs.
Methods/design: The REstart or STop Antithrombotics Randomised Trial (RESTART) is an investigator-led, parallel group, open, assessor-blind, randomised trial comparing starting versus avoiding antiplatelet drugs for adults surviving antithrombotic-associated ICH. Recruitment began on 22 May 2013 and ended on 31 May 2018. Follow-up ends on 30 November 2018. This update to the protocol describes the statistical analysis plan (version 1.6, finalised on 18 September 2018). Data lock is expected to occur on 11 January 2019, after which the un-blinded trial statistician will conduct the final analyses according to this statistical analysis plan.
Discussion: Final results of RESTART will be analysed and disseminated in 2019.
Trial registration: ISRCTN registry 71907627. Prospectively registered on 25 April 2013.
Funding/sponsor: The trial is funded by a British Heart Foundation special project grant (SP/12/2/29422) and a travel fellowship (FS/13/72/30531). The trial sponsor is the Academic and Clinical Central Office for Research and Development (ACCORD), which is a partnership between the University of Edinburgh and NHS Lothian Health Board.
The Effect of Phacoemulsification plus Goniosynechialysis in Acute and Chronic Angle Closure Patients with Extensive Goniosynechiae
Authors: Tian Tian , Li Mei , Pan Yingzi , Cai Yu , Fang Yuan 
Published: December 2018

Abstract
Background Patients with primary angle closure/glaucoma (PAC/PACG) with extensive peripheral anterior synechiae (PAS), and coexisting cataract, increasingly have been treated with phacoemulsification combined with goniosynechialysis (Phaco-GSL). Since the mechanisms of acute and chronic PAC/PACG may differ, the treatment effect of this procedure also may differ. The purpose of this study was to establish whether there was a difference in the therapeutic effect of Phaco-GSL on these patients, which might provide clinical evidence for giving more accurate treatment for them.
Methods This study was a retrospective cohort study. Twenty-seven patients, 13 with acute PAC/PACG and 14 with chronic PAC/PACG, were treated surgically by Phaco-GSL. The intraocular pressure (IOP), surgical success rate, the need of medication, the extent of PAS, the time and the rate of recurrence of PAS (re-PAS) and other indicators were observed post-operatively for at least three months.
Results After surgery, IOP decreased (preoperative vs postoperative: 29.77±11.55 mmHg vs 14.92±1.66 mmHg in the acute group and 26.00±11.2 mmHg vs 14.93±2.7 mmHg in the chronic group), the extent of PAS reduced (preoperative vs. postoperative: 314.23±49.07° vs 116.54±73.78° in the acute group and 285.00±53.28° vs 156.43±56.35° in the chronic group), the topical and systemic anti-glaucoma drug requirements decreased, in both groups and in the acute group, respectively. Compared with the acute group, the success rate (acute vs chronic: 100% vs 64.3%) was lower in the chronic group, while the incidence of re-PAS (acute vs chronic: 30% vs 83.3%) were higher in the chronic group. All differences mentioned above were statistically significant (p < 0.05). In addition, there were five patients in total who showed re-PAS of more than 90° (4 in chronic group and 1 in acute group) and all these re-PASs formed within 1 week postoperatively.
Conclusion Although Phaco-GSL is effective in both groups, there may be differences in the effect between the two groups. Chronic patients are more susceptible to re-PAS. Thus, these patients should be observed closely and treated appropriately in the early post-surgical time period.
Detection of the efficiency of microwave–oxidation process for meat industry wastewater by dielectric measurement
Authors: Jákói Zoltán , Hodúr Cecilia , László Zsuzsanna , Beszédes Sándor 
Published: December 2018

Abstract
Our experimental work focused on the applicability of a quite novel process for wastewater treatment, i.e. a microwave (MW) irradiation-enhanced Fenton-like method. The aim of our research was to detect and evaluate the efficiency of this oxidation process, during the treatment of meat industry wastewater containing a high concentration of organic material. The efficiency was defined by the measurement of the change in COD (chemical oxygen demand, with an initial COD value of 1,568 mg L−1), and with the determination of dielectric parameters during the process. It can be summarized that MW irradiation could assist in a Fenton-like oxidation process to achieve higher organic matter removal. Furthermore, our experimental results and statistical analysis show that there can be found a correlation between the effects of applied MW energy and the dosage of H2O2/FeSO4. If the intensity of MW irradiation and the amount of FeSO4 were set higher, the decrease of COD and the increase of tanδ (the dielectric loss tangent) were definitely more significant. With the application of 60 kJ MWE and a 0.14 mgFe2+/mgCOD dosage, the COD removal efficiency was more than 40%, and the increment of tanδ was nearly threefold. Considering the effects of MW-specific process parameters, it can be concluded that the power intensity of MW–oxidation treatment has a significant effect on COD decrease, if the irradiated MW energy was set at lower (30–45 kJ) levels.
A Comparison of Antioxidant Effects of Some Selected Fruits with Butylated Hydroxytoluene on Egg Yolk
Authors: Mohajer Afsaneh , Sadighara Parisa , Mohajer Mehri , Farkhondeh Tahereh , Samarghandian Saeed 
Published: December 2018

Background:
Antioxidants are commonly used in food products to prolong their shelf life.
Regarding the potential risks of synthetic antioxidants, people’s tendency toward natural antioxidants
is growing. The present study was designed to evaluate the antioxidant activities of some fruits versus
synthetic antioxidants such as Butylated Hydroxytoluene (BHT).

Methods:
In this study, the antioxidant activities of the alcoholic extract of some fruits including
grape, date, olive, fig and pomegranate versus BHT were evaluated by using the egg yolk. The oxidative
stability of samples was measured by thiobarbituric acid reactive substances (TBARS) assay.

Results:
Present findings showed that the levels of lipid oxidation in egg yolk exposed to olive and
pomegranate extracts were similar to the levels of lipid oxidation of egg yolk exposed to BHT.

Conclusion:
The study suggested that pomegranate extract may be used as a natural antioxidant instead
of chemical compounds.
Qualitative and Quantitative Analysis of the Major Ingredients of a Herbal Preparation, Ciwujia Injection by Combination of HPLC-Q-TOF-MS, HPLC-TQ-MS/MS and UPLC-PDA
Authors: Xie Yunjiao , Wang Panpan , Ruan Yijun , Shi Peiying , Yao Hong 
Published: December 2018

Background:
Ciwujia injection, prepared from water extraction of Acanthopanax senticosus,
is widely used for the treatment of cardiovascular diseases in the clinic in China. The ingredients of the
preparation are still not efficiently clear and its quality control method requires further improvement.
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Objective: In this paper, the qualitative and quantitative methods for quality control of Ciwujia injection
were originally developed by a combination of HPLC-Q-TOF-MS, HPLC-TQ-MS/MS and UPLCPDA.

Methods:
With HPLC-Q-TOF-MS and HPLC-TQ-MS/MS, compounds were identified firstly by comparison
of their MS spectra and retention times with those of standards or recorded information in the
literature. Further, a new UPLC-PDA method was originally established to simultaneously determine
the multiple ingredients in the preparations.

Results:
For qualitative analysis, 22 compounds were identified by the presented method. For quantitative
analysis, the validated method exhibited good linearity (R2 > 0.998), repeatability (RSD < 1.50%),
intra- and inter-day precisions (RSD < 8.33%) and recoveries (95.93-108.58%) for the simultaneous
determination of the active ingredients, including protocatechuic acid-3-glucoside, l-phenylalanine,
protocatechuic acid, neochlorogenic acid, chlorogenic acid, gentiopicroside, eleutheroside B, and cryptochlorogenic
acid, and was successfully utilized to analyze the eight compounds in 4 batches of Ciwujia
injection.

Conclusion:
The presented method is simple and rapid for quality control of Ciwujia injection, and
could provide a useful reference for the quality control and routine analysis of others Ciwujia preparations.
Kesiagaan Perpustakaan dalam Menghadapi Bencana di Perpustakaan Universitas Sebelas Maret Surakarta
Authors: Haryanto Haryanto 
Published: December 2018

This research aims to find out the preparedness of libraries in facing disasters caused either human or natural factors. Disasters caused human factors are fire, theft and various kinds of acts of vandalism, while disasters caused by natural factors are earthquakes, floods and the threat of devastating animal collection. The research method used in the study is qualitative field research. Data were obtained through observation and note-taking, as well as participation in the activities. Disaster preparedness activities were conducted in stages, prevention, response, reaction and recovery. These activities included filling up visit book, CCTV cameras, availability of portable fire extinguisher and SOP (standard operating procedure) that put priority in securing the collection, repair, creation of data backup and recovery, media transfer, procurement of collection and extensive simulation handling of fire and other emergency conditions.
Evaluasi Pemanfaatan Koleksi Buku Digital oleh Mahasiswa Pendidikan Dokter di Unit Perpustakaan Fakultas Kedokteran Universitas Gadjah Mada (FK UGM)
Authors: Sukirno Sukirno 
Published: December 2018

Role and function of library unit of medical faculty of Gajah Mada university prepares instrument and support facilities for student of medical education, namely preparing many kinds of information sources in health and medical unit. To fulfill the information need for student, it prepares information sources in various formats, either in printed form or digital form. Printed format is by preparing books, scholarly paper, government published, and magazine. Meanwhile, digital format includes books, scholarly paper, articles, even subscribe database in health and medical unit. Preparing this digital book collection is relevan with student tendency of medical education program in using collection. So that, this research will evaluate the utility of digital book collection by student of medical education of medical faculty of GajahMadaUniversity. The problem formulation is how the student of medical faculty of Gajah Mada university utilize the digital book collection. The purpose oh this research are: (1) knowing the utility of digital book collection by student of medical education of medical faculty of Gajah Mada University., (2) giving opinion to library unit of medical faculty of Gajah Mada University in taking policy to develop digital book collection, (3) giving opinion to the organizer of medical education of medical faculty of Gajah Mada University about the utility of book collection. The method in this research is by using quantitative approach with 94 respondents of medical education student. Based on result and discussion in this research , it is known that the evaluation of digital book collection utility can be categorized good, if the score average is 85,3975 %. Almost all of the indicators get category good., except interest indicator of user. Their category is sufficient because the question for respondents in minor question form. Meanwhile recommendation based on respondents suggestions of proposals are: (1) access of digital book collection can be done from home or beyond of medical faculty area ofGajahMadaUniversity, (2) update digital book collection always be done, (3) library unit of medical faculty ofGajahMadaUniversity intensively socializes to student about the utility of digital book collection.
Analisis Potensi dan Strategi Pengembangan Pariwisata Berkelanjutan Berbasis Komunitas di Desa Sembungan, Wonosobo, Jawa Tengah
Authors: Budiani Sri Rahayu , Wahdaningrum Windarti , Yosky Dellamanda , Kensari Eline , Pratama Hendra S , Mulandari Henny , Iskandar Heru Taufiq Nur , Alphabettika Mica , Maharani Novela , Febriani Rizka Fitria , Kusmiati Yanti 
Published: December 2018

Pembangunan pariwisata saat ini diarahkan kepada pembangunan pariwisata yang berkelanjutan dengan pengembangan yang didasarkan atas prinsip pemberdayaan berbasis masyarakat. Salah satu desa yang potensial dikembangkan dengan prinsip-prinsip tersebut adalah Desa Sembungan. Metode penelitian kualitatif digunakan untuk melihat potensi pengembangan wisata Desa Sembungan. Berdasarkan hasil penelitian diketahui Desa Sembungan memiliki sumberdaya alam yang potensial, namun saat ini hanya dua objek wisata alam yang dikembangkan, yaitu Bukit Sikunir dan Telaga Cebong sehingga masih sangat mungkin untuk ditemukan objek wisata yang memiliki daya tarik. Desa Sembungan pada prinsipnya belum memenuhi prinsip pembangunan pariwisata berkelanjutan, sehingga perlu adanya pembenahan diberbagai aspek. Dilihat dari tujuh prinsip pembangunan pariwisata berbasis komunitas, maka Desa Sembungan masih belum memenuhi tujuh prinsip tersebut, sehingga diperlukan arahan strategi yang tepat untuk mendorong pengembangan pariwisata berkelanjutan berbasis masyarakat di Desa Sembungan. ABSTRACT Tourism development today is directed to achieve sustainable tourism development following the community-based empowerment principles. Sembungan village is one of the potential village to be developed with those principles. Qualitative research method is used for this research. The result shows that Sembungan village has potential natural resources, but unfortunately only two attractions are developed, they are sikunir hill and telaga cebong. There are more alluring tourism objects in Sembungan village that haven’t been explored. Sembunga village has not yet manage tourism activities based on sustainable tourism principles. Accordingly, there are many aspects that need to be fixed. Tourism management also has not achieved the seven community-based tourism developments principles. Sembungan village still needs more precise strategies and plans to force sustainable community-based tourism development.
Práticas de “racialização” observadas em narrativas de camponeses que se deslocaram na década de 1950 a cidade de Sobral/Ceará
Authors: Adriao Maria Antonia Veiga 
Published: December 2018

Neste artigo, analiso práticas de “racialização” observadas em narrativas de migrantes que entrevistei para a pesquisa de doutorado, quando investiguei o movimento migratório realizado por camponeses moradores da região “Sertão Centro Norte Cearense” que, em grande medida, teve como destino a cidade de Sobral, também situada nessa região. As fontes que trouxe para este artigo foram narrativas orais; relatórios demográficos do Instituto Brasileiro de Geografia e Estatística (IBGE) e uma bibliografia interdisciplinar que ajudaram a compreender como os entrevistados colocaram em prática seu aprendizado geracional para justificarem suas escolhas na convivência social nessa cidade.
Repair or Observation of Resin Margin Defects: Clinical Trial After Five Years
Authors: Dennison JB , Yaman P , Fasbinder DJ , Herrero AA 
Published: December 2018

SUMMARY

Objective:
To assess the effectiveness of repair/resealing of stained composite margins as an alternative to controlled observation without treatment in a randomized clinical trial after five years.

Methods and Materials:
Each patient recruited had from one to three composite restorations with visible margin discoloration. Initially, the characteristics of each defect were recorded with direct vision through a surgical microscope at 20× magnification. Clinical evaluation was done by two independent examiners using modified USPHS criteria for color, margin discoloration, and margin adaptation. Each restoration was then randomly assigned to a control or treatment group. Control restorations were observed yearly for the presence of recurrent caries; treatment restorations were resealed by exposing the margin with a ¼ round bur, removing all interfacial stain, acid etching, placing an adhesive bonding agent, and a flowable composite to restore margin integrity. There were 152 patients recruited, with 360 restorations (180 control and 180 treatment).

Results:
At five years, 104 patients were recalled (68%) with 271 restorations (76%): 136 untreated control and 135 resealed restorations. At that time, 61 restorations had been lost or replaced for nonrelated reasons. Clinical evaluation of the remaining 210 restorations determined penetrating discoloration (control = 81%, resealed = 46%) and margin crevice formation (control = 21%, resealed = 11%). Recurrent caries was diagnosed cumulatively in only six control and five treatment restorations (&lt;5%). Microscopically, 49 control restorations (49%) and 36 resealed restorations (33%) had crevice formation. Discoloration was distributed as follows: 9% vs 47% with no discoloration, 30% vs 33% in the composite, 49% vs 18% in the interface, and 12% vs 2% in tooth structure.

Conclusions:
Resealing of restorations with margin discoloration reduced the occurrence of penetrating stain from 81% in controls to 46% in resealed margins and crevicing from 21% to 11% after five years. Both controlled observation and resealing of margins resulted in a similar very low incidence (&lt;6%) of recurrent caries.