bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-23 mediates murine liver transplantation ischemia-reperfusion injury via IFN-γ/IRF-1 pathway
Authors: Klune John R. , Bartels Christian , Luo Jing , Yokota Shinichiro , Du Qiang , Geller David A. 
Published: October 2018

Interleukin-23 (IL-23) is a proinflammatory cytokine initially studied in autoimmune disease that has been more recently linked to innate immunity. We observed that the expression of IL-23 is upregulated during hypoxia in a hepatocyte and nonparenchymal cell (NPC) coculture system, as well as during ischemia-reperfusion (I/R) injury in the liver. Interferon regulatory factor-1 (IRF-1) is a transcription factor that induces expression of multiple inflammatory cytokines and has been shown to play a critical role in liver I/R injury. We observed that IL-23 signaling induces not only the IL-17/chemokine (C-X-C motif) ligand 2 (CXCL2) pathway but also the IFN-γ/IRF-1 pathway. Quantification of cytokine genes revealed increased liver expression of IL-17a, CXCL2, and IRF-1 messenger RNA during liver transplantation. Recombinant IL-23 treated hepatocytes, and NPC coculture led to IL-17, CXCL2, IFN-γ, and IRF-1 expression. With anti-IL-17 and anti-Ly6G antibody neutralization, neutrophil recruitment and IFN-γ production were decreased during warm I/R injury. Overexpression of IL-23 in vivo through use of an adenovirus vector also led to expression of IL-17, CXCL2, IFN-γ, and IRF-1. The increased expression of IL-23 also led to increased apoptosis in the liver. By neutralization of IL-23 through use of an anti-IL-23p19 antibody, we were able to attenuate liver damage in a wild-type but not a natural killer T (NKT) cell-deficient mouse. This suggests that IL-23 signaling shares a common pathway with NKT cells. In conclusion, IL-23 is induced early by I/R in the liver. Its signaling leads to activation of the IL-17/CXCL2 and IFN-γ/IRF-1 pathways, resulting in increased apoptosis and necrosis. NEW & NOTEWORTHY IL-23 is expressed early during cold ischemia-reperfusion (I/R), and this expression is associated with expression of IL-17 and chemokine (C-X-C motif) ligand 2. Neutralization of IL-23 during cold I/R can significantly reduce liver damage as well as decrease cytokine production and neutrophil infiltration in the liver. IL-23 appears to activate IFN-γ production in natural killer T cells within the liver which, in turn, activates interferon regulatory factor-1, a known inflammatory transcription factor during I/R injury.
Testing the vagal withdrawal hypothesis during light exercise under autonomic blockade: a heart rate variability study
Authors: Fontolliet Timothée , Pichot Vincent , Bringard Aurélien , Fagoni Nazzareno , Adami Alessandra , Tam Enrico , Furlan Raffaello , Barthélémy Jean-Claude , Ferretti Guido 
Published: October 2018

We performed the first analysis of heart rate variability (HRV) at rest and during exercise under full autonomic blockade on the same subjects, to test the conjecture that vagal tone withdrawal occurs at exercise onset. We hypothesized that between rest and exercise there would be 1) no differences in total power (PTOT) under parasympathetic blockade, 2) a PTOT fall under β1-sympathetic blockade, and 3) no differences in PTOT under blockade of both autonomic nervous system branches. Seven men [24 (3) yr, mean (SD)] performed 5-min cycling (80 W) supine, preceded by 5-min rest during control and with administration of atropine, metoprolol, and atropine + metoprolol (double blockade). Heart rate and arterial blood pressure were continuously recorded. HRV and blood pressure variability were determined by power spectral analysis, and baroreflex sensitivity was determined by the sequence method. At rest, PTOT and the powers of low- and high-frequency components of HRV (LF and HF, respectively) were dramatically decreased with atropine and double blockade compared with control and metoprolol, with no effects on LF-to-HF ratio and on the normalized LF (LFnu) and HF (HFnu). During exercise, patterns were the same as at rest. Comparing exercise with rest, PTOT varied as hypothesized. For systolic and diastolic blood pressure, resting PTOT was the same in all conditions. During exercise, in all conditions, PTOT was lower than in control. Baroreflex sensitivity decreased under atropine and double blockade at rest and under control and metoprolol during exercise. The results support the hypothesis that vagal suppression determined disappearance of HRV during exercise. NEW & NOTEWORTHY This study provides the first demonstration, by systematic analysis of heart rate variability at rest and during exercise under full autonomic blockade on the same subjects, that suppression of vagal activity is responsible for the disappearance of spontaneous heart rate variability during exercise. This finding supports previous hypotheses on the role of vagal withdrawal in the control of the rapid cardiovascular response at exercise onset.
Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure
Authors: Li Jie , Yue Guihua , Ma Wenxia , Zhang Aizhen , Zou Jianqiu , Cai Yafei , Tang Xiaoli , Wang Jun , Liu Jinbao , Li Honglin , Su Huabo 
Published: October 2018

Background:
Defects in protein homeostasis are sufficient to provoke cardiac remodeling and dysfunction. Although posttranslational modifications by ubiquitin and ubiquitin-like proteins are emerging as an important regulatory mechanism of protein function, the role of Ufm1 (ubiquitin-fold modifier 1)—a novel ubiquitin-like protein—has not been explored in either the normal or stressed heart.

Methods and Results:
Western blotting revealed that Ufl1 (Ufm1-specific E3 ligase 1)—an enzyme essential for Ufm1 modification—was increased in hypertrophic mouse hearts but reduced in the failing hearts of patients with dilated cardiomyopathy. To determine the functional role of Ufl1 in the heart, we generated a cardiac-specific knockout mouse and showed that Ufl1-deficient mice developed age-dependent cardiomyopathy and heart failure, as indicated by elevated cardiac fetal gene expression, increased fibrosis, and impaired cardiac contractility. When challenged with pressure overload, Ufl1-deficient hearts exhibited remarkably greater hypertrophy, exacerbated fibrosis, and worsened cardiac contractility compared with control counterparts. Transcriptome analysis identified that genes associated with the endoplasmic reticulum (ER) function were dysregulated in Ufl1-deficient hearts. Biochemical analysis revealed that excessive ER stress preceded and deteriorated along with the development of cardiomyopathy in Ufl1-deficient hearts. Mechanistically, Ufl1 depletion impaired (PKR-like ER-resident kinase) signaling and aggravated cardiomyocyte cell death after ER stress. Administration of the chemical ER chaperone tauroursodeoxycholic acid to Ufl1-deficient mice alleviated ER stress and attenuated pressure overload-induced cardiac dysfunction.

Conclusions:
Our results advance a novel concept that the Ufm1 system is essential for cardiac homeostasis through regulation of ER function and that upregulation of myocardial Ufl1 could be protective against heart failure.
Outcomes Among Patients Undergoing Distal Left Main Percutaneous Coronary Intervention
Authors: Kandzari David E. , Gershlick Anthony H. , Serruys Patrick W. , Leon Martin B. , Morice Marie-Claude , Simonton Charles A. , Lembo Nicholas J. , Banning Adrian P. , Merkely Béla , van Boven Ad J. , Ungi Imre , Kappetein Arie Pieter , Sabik Joseph F. , Généreux Philippe , Dressler Ovidiu , Stone Gregg W. 
Published: October 2018

Background:
Distal left main (LM) coronary artery bifurcation disease increases percutaneous coronary intervention (PCI) procedural complexity and is associated with worse outcomes than isolated ostial/shaft disease. The optimal treatment strategy for distal LM disease is undetermined. We sought to determine whether outcomes after PCI of LM distal bifurcation lesions are influenced by treatment with a provisional 1-stent versus planned 2-stent technique, and if so, whether such differences are conditioned by the complexity of the LM bifurcation lesion.

Methods and Results:

The clinical and angiographic characteristics, procedural methods and outcomes, and clinical events through 3-year follow-up were compared in patients undergoing distal LM PCI with a 1-stent provisional versus planned 2-stent technique in the EXCEL trial (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization). Among 529 patients undergoing planned distal LM PCI, 344 (65.0%) and 185 (35.0%) were treated with intended 1-stent provisional and planned 2-stent techniques, respectively. The primary composite end point rate of death, myocardial infarction, or stroke at 3 years was significantly lower in patients treated with the provisional 1-stent versus planned 2-stent method (14.1% versus 20.7%; adjusted hazard ratio, 0.55; 95% CI, 0.35–0.88;
P
=0.01), driven by differences in cardiovascular death (3.3% versus 8.3%,
P
=0.01) and myocardial infarction (7.7% versus 12.8%,
P
=0.06). The 3-year rate of ischemia-driven revascularization of the LM complex was also lower in the provisional group (7.2% versus 16.3%,
P
=0.001). In 342 patients with distal LM bifurcation disease that did not involve both major side branch vessels, the 3-year primary end point was lower with a provisional 1-stent versus planned 2-stent technique (13.8% versus 23.3%,
P
=0.04), whereas no significant difference was present in 182 patients with distal LM bifurcation disease that did involve both side branch vessels (14.3% versus 19.2%,
P
=0.36).

Conclusions:
Among patients with distal LM bifurcation disease in the EXCEL trial randomized to PCI, 3-year adverse outcomes were worse with planned 2-stent treatment compared with a provisional 1-stent approach, a difference that was confined to patients without major involvement of both LM side branch vessels.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01205776.
Are You Smarter Than a Cetacean?: Death Reminders and Concerns About Human Intelligence
Authors: Soenke Melissa , Cohen Florette , Greenberg Jeff , Lifshin Uri 
Published: October 2018

Abstract
Terror management theory and research indicate that humans cope with concerns about mortality by believing we are more than nonhuman animals. The current studies investigated whether this motivation plays a role in believing humans are more intelligent than other animals. Study 1 had participants think about mortality or another unpleasant topic. The study found that after the death reminder, participants had more negative reactions to a scientific article describing dolphins as smarter than humans, but not to an article that merely focused on dolphins’ intelligence. Study 2 had participants read an article about dolphins being smarter than humans or an article describing dolphin intelligence without a comparison to humans. Participants then completed a measure that assessed how close to consciousness thoughts of death were. Those who read that dolphins were smarter than humans exhibited higher levels of death-related thought. These results may have important implications for conserving intelligent animal species.
Rhythm and Existence
Authors: Schuback Marcia Sá Cavalcante 
Published: October 2018

Abstract
The present article proposes a reflection on the relation between music and language setting out from the experience of listening to words and listening to music. It relies to a certain extent upon an existential-phenomenological approach and develops the distinction between the sounding of sounds (sounding words) and the sound of sounding (musical sounds). From this distinction, a redefinition of rhythm is suggested based on the experience of listening and on the close listening to some pieces of music.
Corporatist Institutions and Militant Actions
Authors: Park Jinyoung 
Published: October 2018

Abstract
Drawing on data from archives and fieldwork in Myanmar, a country in political change from a five-decade authoritarian regime to a quasi-civilian one, this study explores the reasons for a prevalence of corporatist aspects at the early stage of reforms. The early introduction of corporatism in Myanmar diverges from other Asian countries that experienced transitions accompanied by labour militancy, and only later embraced corporatism when political power shifted to elected pro-labour parties. This article argues, first, that corporatism prevails in the rhetoric of the labour movement and in Myanmar’s industrial relations institutions, while labour militancy has simultaneously increased; second, corporatism in Myanmar has few historical precedents but has recently been promoted primarily by the International Labour Organisation (ILO); and third, while corporatism has failed to bring about industrial peace, the rhetoric and institutions of corporatism may limit the political potential of Myanmar’s labour movement by restricting unions’ activities to economic concerns.
Effects of pond structural complexity on the reproduction of Physalaemus ephippifer (Anura, Leptodactylidae)
Authors: Rodrigues Lenise Chagas , Correa Fabricio Simões , Juen Leandro , dos Santos-Costa Maria Cristina 
Published: October 2018

Abstract
Habitat structure is a factor that strongly affects the distribution of organisms. Habitats with high structural complexity provide a high number of microhabitats, allowing the coexistence of species with different behavioral, ecological and physiological requirements. We analyzed the effects of structural complexity of ponds on the number of males and foam nests of Physalaemus ephippifer, and the substrates to which individuals attach their foam nests. We sampled 41 ponds and recorded the number of individuals of P. ephippifer and environmental data (type of vegetation in, adjacent and around the pond; type of bottom substrate in the pond) to measure the degree of structural complexity of the ponds through an index ranging between 0 and 1. We found a positive influence of pond structural complexity on mean number of calling males, but not on number of foam nests. We found most foam nests attached to gramineans and herbaceous plants. Vegetation is an important component of habitats with high complexity, providing refuges for adults and tadpoles. The index was an efficient tool to measure habitat structural complexity, and may be used in further studies with other species.
The effect of olive (Olea europaea L.) phenolics and sugar on Drosophila melanogaster’s development
Authors: Güneş Eda , Danacıoğlu Derya Arslan 
Published: October 2018

AbstractOlive leaves (Olea europaeaL.) contain phenolics that are used for various aims and can also be utilized as free radical scavengers and as a powerful antioxidant source. In this study, our aim was to observe the effects of olive phenolics on the survival rate, development, sex ratio, and adult longevity ofDrosophila melanogasterMeigen (Diptera: Drosophilidae) fed with sugar and with a sugar-free diet. The amount of malondialdehyde and the activity of glutathione S-transferase were examined with UV-VIS spectrophotometry in third-stage larvae, pupae and adults. For this purpose, dried olive fruit and leaf extracts were added at different concentrations to the insect’s sugary diets. The results reveal that 12 mg/L phenolic fruit extract and 4 M sucrose had a negative impact on the development and survival of these insects. It was also found that phenolic leaf extract and low sugar concentrations changed the sex ratio, leading to fewer females and more males. The use of phenolic fruit and phenolic leaf extracts with increased sugar-based diets raised the amount of oxidation as well as the detoxification activity in this model organism. These results demonstrate that low amounts of sugar and olive phenolics may be used as an adjunct to adult nutrients to improve the insect’s adult characteristics.
Precipitation Forecast Experiments Using the Weather Research and Forecasting (WRF) Model at Gray-Zone Resolutions
Authors: Han Ji-Young , Hong Song-You 
Published: October 2018

Abstract
In the Weather Research and Forecasting (WRF) community, a standard model setup at a grid size smaller than 5 km excludes cumulus parameterization (CP), although it is unclear how to determine a cutoff grid size where convection permitting can be assumed adequate. Also, efforts to improve high-resolution precipitation forecasts in the range of 1–10 km (the so-called gray zone for parameterized precipitation physics) have recently been made. In this study, we attempt to statistically evaluate the skill of a gray-zone CP with a focus on the quantitative precipitation forecast (QPF) in the summertime. A WRF Model simulation with the gray-zone simplified Arakawa–Schubert (GSAS) CP at 3-km spatial resolution over East Asia is evaluated for the summer of 2013 and compared with the results from a conventional setup without CP. A statistical evaluation of the 3-month simulations shows that the GSAS demonstrates a typical distribution of the QPF skill, with high (low) scores and bias in the light (heavy) precipitation category. The WRF without CP seriously suppresses light precipitation events, but its skill for heavier categories is better. Meanwhile, a new set of precipitation data, which is simply averaged precipitation from the two simulations, demonstrates the best skill in all precipitation categories. Bearing in mind that high-resolution QPF requires essential challenges in model components, along with complexity in precipitating convection mechanisms over geographically different regions, this proposed method can serve as an alternative for improving the QPF for practical usage.
Driver Vigilance in Automated Vehicles: Effects of Demands on Hazard Detection Performance
Authors: Greenlee Eric T. , DeLucia Patricia R. , Newton David C. 
Published: October 2018

Objective: The current study investigated driver vigilance in partially automated vehicles to determine whether increased task demands reduce a driver’s ability to monitor for automation failures and whether the vigilance decrement associated with hazard detections is due to driver overload. Background: Drivers of partially automated vehicles are expected to monitor for signs of automation failure. Previous research has shown that a driver’s ability to perform this duty declines over time. One possible explanation for this vigilance decrement is that the extreme demands of vigilance causes overload and leads to depletion of limited attentional resources required for vigilance. Method: Participants completed a 40-min drive in a simulated partially automated vehicle and were tasked with monitoring for hazards that represented potential automation failures. Two factors were manipulated to test the impact of monitoring demands on performance: Spatial uncertainty and event rate. Results: As predicted, hazard detection performance was poorer when monitoring demands were increased, and performance declined as a function of time on task. Subjective reports also indicated high workload and task-induced stress. Conclusion: Drivers of partially automated vehicles are impaired by the vigilance decrement and elevated task demands, meaning that safe operation becomes less likely when the demands associated with monitoring automation increase and as a drive extends in duration. This study also supports the notion that vigilance performance in partially automated vehicles is likely due to driver overload. Application: Developers of automation technologies should consider countermeasures that attenuate a driver’s cognitive load when tasked with monitoring automation.
Modeling airborne nanoparticle filtration through a complete structure of non-woven material used in protective apparel
Authors: Vinches Ludwig , Tuduri Ludovic , Hallé Stéphane 
Published: October 2018

Airborne nanoparticles represent a new danger in occupational health. Numerous theoretical and experimental studies have been conducted on the efficiency of filtering media used for respiratory protection, but few have focused on media used for skin protective equipment. Indeed, a significant proportion of airborne nanoparticles can end up on the skin, causing local effects and eventually penetrating the human body. Following experimental data obtained with sodium chloride nanoparticles, the authors propose an empirical model to evaluate the penetration of airborne nanoparticles through medium used in disposable coveralls. This study presents an adaptation of the conventional filtration theory used for filtering media used in respirators. The authors' model is compared with Wang et al.'s and Brochot's models and demonstrates improvements in their descriptive ability. Moreover, a domain of validity of the proposed model was determined that will enable the evaluation of the efficiency of similar protective apparel material structures against airborne nanoparticles.
Patterns of Physical Activity Adherence by Adolescents With Diabetes or Obesity Enrolled in a Personalized Community-Based Intervention
Authors: Michaliszyn Sara F. , Higgins Melinda , Faulkner Melissa Spezia 
Published: October 2018

Purpose The purpose of this study was to determine the feasibility of a personalized, 16-week community-based physical activity intervention for adolescents with diabetes or obesity and examine the weekly patterns of adherence to the intervention. Methods Physical activity adherence was evaluated throughout the intervention using accelerometers in 46 adolescents with type 1 diabetes (N = 22), type 2 diabetes (N = 12), or obesity (N = 12) (age, 14.4 ± 1.5 years; 56.5% female; 61% Hispanic). Of these, 39 completed the intervention, and 7 did not. Results There were no differences in baseline anthropometric characteristics or fitness between the completers versus noncompleters. Completers began above 1060 metabolic equivalent (MET) min/wk−1and stayed above 900 MET min/wk−1 for ~4 weeks and declined 39 MET min/wk−1 until end of study. Noncompleters began at 924 MET min/wk−1 yet dropped below 800 MET min/wk−1 by end of week 1 and declined an average of 151 MET min/wk−1. Interestingly, self-report of barriers to activity were higher in completers versus noncompleters. Conclusions Findings highlight that adolescents completing the intervention could sustain a prescribed level of personalized activity for at least 1 month but had steadfast declines in weekly activity. Even with individualized programs, factors other than barriers to activity need to be considered when designing approaches to physical activity adherence for adolescents with diabetes or obesity.
A systematic review and meta-analysis of prevalence of vitamin D deficiency among adolescent girls in selected Indian states
Authors: Jeyakumar Angeline , Shinde Vidhya 
Published: October 2018

Background: Vitamin D deficiency among adolescents is an emerging public health priority as adolescence marks a period of rapid growth and the onset of the reproductive phase. However, lack of national prevalence data and intervention strategies is of public health concern. Objective: The objective of this study was to determine the pooled prevalence of vitamin D deficiency among adolescent girls in selected Indian states. Methods: A systematic literature review was performed using three different search engines. The searches yielded nine eligible articles. Study quality was assessed for 10 different criteria. Meta-analysis was performed to estimate pooled prevalence of vitamin D deficiency among adolescent girls and to assess the heterogeneity among selected studies. Results: A sample of n=1352 was used to study prevalence among adolescent girls. The random effects combined estimate for overall prevalence was 25.70% (95% CI 3.89–2137.9). High heterogeneity (tau2=1.71, I2=100%) was observed and seven out of nine studies showed low to moderate risk and two showed high risk of bias. The test for overall effect was observed to be Z=0.77 ( p=0.44). Conclusions: High prevalence of vitamin D deficiency among adolescent girls identifies the need to introduce screening of adolescents and introduce proven public-health interventions such as fortification of foods to address deficiency.