bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomic factors as contributing risk factors in implant therapy
Authors: Ramanauskaite Ausra , Becker Jürgen , Sader Robert , Schwarz Frank 
Published: August 2019

AbstractDamage to the critical anatomic structures during dental implant placement can lead to serious complications, including intra‐ or postoperative bleeding, hematoma formation, or varying degrees of neurosensory alteration. These complications usually occur when the anatomic features of the major blood vessels and their anastomoses, neurovascular bundles, and alveolar ridge contour are not properly investigated prior to the surgery. Therefore, having proper knowledge of specific anatomic factors is key to avoiding intra‐ and postsurgical complications. The aim of the current review is to summarize the anatomic structures and their variations in the mandible and maxilla as contributing risk factors in implant therapy.
(Re)theorizing civic engagement: Foundations for Black Americans civic engagement theory
Authors: Robinson Candice C. 
Published: August 2019

AbstractCommonly known as “civic engagement,” getting involved within communities in a formalized way has served a foundational role in the development of the United States. Missing from foundational conceptualizations of analyses is theoretical and empirical research that does not center White people and experiences. In this article, I argue that researchers need to incorporate an understanding of Black American's relationship with civic engagement to increase the accuracy of literature on civic engagement. Toward this goal, I first outline the foundational conceptualizations of civic engagement. I next discuss the limitations of civic engagement theories with a focus on data sources and the exclusion of non‐White persons within foundational texts. I then highlight the historical civic activities of Black Americans that has been foregrounded in research on Black voluntary associations. This project pushes for a discussion on the relationship between civic engagement and race with a focus on Black Americans that is relevant to sociological understandings of civil society. I conclude by discussing how filling this gap has a far‐reaching impact in the field of collective behavior and social movements.
Making a murderer: The importance of gender and violence against women in mass murder events
Authors: Marganski Alison J. 
Published: August 2019

AbstractThis article examines sex, gender, and gender violence (e.g., dating/domestic violence, sexual assault, and stalking) as related to mass murder events. Specifically, the paper explores (a) sex/gender and mass murder and (b) violence against women prior to and directly associated with mass murder events. A multidimensional framework guided by critical feminist thought is presented to offer a nuanced approach to understanding offending. The paper argues that mass murder, a gendered phenomenon, is a way by which some individuals “do gender,” an expression of aggrieved entitlement and representation of toxic masculinity resulting from the collision of individual, relational, community, and cultural forces that impact perpetrator attitudes, decisions, and behavior. The paper advances knowledge by drawing attention to men's violence against women preceding mass murder events, one of the most common yet overlooked risk factors. Other gendered aspects are also discussed. In all, findings suggest that sexist beliefs/norms stemming from gender role expectations in patriarchal cultures are reinforced by male peer support and institutional failures that fuel violence against women and mass murder events. Thus, if we are to tackle the issue of mass murder, we need to take the lived experiences of women and girls more seriously and work on gendered‐oriented and gender‐informed solutions.
Gun Ownership as a Social Identity: Estimating Behavioral and Attitudinal Relationships
Authors: Lacombe Matthew J. , Howat Adam J. , Rothschild Jacob E. 
Published: August 2019

ObjectiveRecent research suggests that a gun owner social identity may undergird the deep political engagement of U.S. gun rights supporters. We adapt social psychological measures to assess whether such an identity does indeed exist, examine the factors that predict whether individuals hold the identity, and assess whether the identity predicts individuals’ political attitudes and participation.MethodsWe analyze two distinct survey data sets using various statistical techniques: (1) an original Mechanical Turk survey and (2) a survey of gun owners conducted by the Pew Research Center.ResultsGun owner identity is an individual characteristic that can be meaningfully measured. Moreover, gun owner identity is predicted by contact with the National Rifle Association and participation in gun‐related social activities, among other factors. Further, this identity strongly predicts firearm‐related policy attitudes, the importance individuals place upon these issues, and their propensity to act in opposition to gun regulations, all independent of gun ownership.ConclusionsOur results suggest that nuanced measurement of gun owner identity can provide a richer understanding of gun policy attitudes, identity politics, and interest group influence. In so doing, they help explain gun rights supporters’ unusual dedication and, by extension, the NRA's success in the realm of gun policy.
Multilocus phylogeny defines a new classification of Staphylininae (Coleoptera, Staphylinidae), a rove beetle group with high lineage diversity
Authors: Żyła Dagmara , Solodovnikov Alexey 
Published: August 2019

AbstractWe provide the first multilocus molecular phylogeny of a group corresponding to the former subfamily Staphylininae. Results are corroborated by the morphological, biogeographical and palaeobiological evidence to serve as a baseline for an updated suprageneric classification. The former subfamily Staphylininae is proven to be a lineage sister to the monophyletic Paederinae and reclassified according to a robust phylogeny resolving a number of long‐standing controversies. The subfamily Xantholininae (revised status) is reinstated to contain the tribes Xantholinini, Othiini, Maorothiini and Diochini. Subfamily Platyprosopinae (revised status) is reinstated for the tribes Platyprosopinini, Arrowinini and †Thayeralinini. For a highly peculiar genusCoomaniaCameron, formerly in Diochini, a new subfamily Coomaniinaesubfam.n.is established and the composition of Diochini (revised status) is changed accordingly. The subfamily Staphylininae (revised status) is reduced to contain the former tribe Staphylinini only. Elevating this mega‐diverse tribe to the subfamily rank opened up an opportunity for its more fractional classification by raising several subtribes to the tribal level as follows: Acylophorini, Afroquediini, Amblyopinini, Antimerini, †Baltognathini, Cyrtoquediini, Erichsoniini, Hyptiomini, Indoquediini, Quediini and Tanygnathinini (revised status for all). As a result, the most species‐rich tribe Staphylinini (revised status) is reduced to the more homogeneous lineage containing the subtribes Algonina, Anisolinina, Philonthina, Philothalpina, Staphylinina and Xanthopygina. Morphological synapomorphies and diagnostic characters supporting all newly defined higher taxa are provided.This published work has been registered on ZooBank,http://zoobank.org/urn:lsid:zoobank.org:pub:DED8B042‐83C9‐4D10‐B0CB‐B50372B067A9.
Post “Post‐Truth”: Are We There Yet?
Authors: Haack Susan 
Published: August 2019

AbstractAfter explaining why, after dealing with post‐modernist confusions about truth in various books and articles from the mid‐1990s to, most recently, 2014 (§1), Haack returns to the topic of truth. She begins (§2) with some thoughts about the claim that concern for truth is on the decline, and perhaps at a new low; a claim that, sadly, may well be true. Then (§3) she looks at some of the many forms that carelessness with the truth may take, and shows that, so far from revealing that the concept of truth is seriously problematic or that there is no such thing as objective truth, it simply makes no sense to say that lies, half‐truths, etc., are ubiquitous unless there is such a thing as truth, and a legitimate truth‐concept. After that, (§4) she argues that, of course, there is such a thing as objective truth, and a robust truth‐concept. And finally, (§5) she suggests some ways to fight against the rising tide of unconcern for truth—and gives her answer to the (trick) question in her subtitle.
Bank credit, public financial incentives, tax financial incentives and export performance during the global financial crisis
Authors: Okafor Luke Emeka , Bhattacharya Mita , Apergis Nicholas 
Published: August 2019

AbstractThis paper investigates the extent to which access to credit, public financial incentives and tax financial incentives affect export performance using the EU‐EFIGE/Bruegel‐Unicredit data set, covering firms within Austria, France, Germany, Italy, Spain, Hungary and the UK during the 2008 global financial crisis. The results show that firms receiving credit or benefiting from public financial incentives display higher export intensity and export a greater number of product lines compared to those that did not, especially in countries with better access to credit and/or financial incentives during the crisis. Further, firms benefiting from tax financial incentives show a better export performance compared to those that did not, regardless of the degree of access to credit and/or financial incentives in the country in which they operate. In addition, the effect of access to credit and public finance incentives on export performance is found to be size‐dependent, while the effect of tax financial incentives is not. We suggest that governments should promote publicly funded financial incentives along with conventional schemes, such as R&D subsidies, to promote exports, particularly during a period of financial crisis.
Welfare and trade elasticity with multinational production
Authors: Bombarda Pamela , Marcassa Stefania 
Published: August 2019

AbstractWe explore welfare properties in a firm heterogeneity model with multinational production and export. The presence of multinational production plays a crucial role in delivering a partial trade elasticity of total sales by exporters and affiliates that is no longer constant, and depends on both supply and demand parameters. We then analyse counterfactual scenarios. Multinational production with intra‐firm trade increases welfare gains by up to 4% with respect to a model with only export and no truncation. Multinational production à la Helpman et al. (American Economic Review, 2004, 94, 300) generates the largest welfare gains from liberalisation.
Birth of the East African Rift System: Nucleation of magmatism and strain in the Turkana Depression
Authors: Boone Samuel C. , Kohn Barry P. , Gleadow Andrew J.W. , Morley Christopher K. , Seiler Christian , Foster David A. 
Published: August 2019

AbstractThe Turkana Depression of northern Kenya and southern Ethiopia contains voluminous plume-related basalts that mark the onset of the Paleogene–recent East African Rift System (EARS) at ca. 45 Ma. Thus, the Turkana Depression is crucial to understanding the inception of intracontinental rifting. However, the precise chronology of early rift-basin formation in Turkana is poorly constrained. We present apatite fission-track and (U-Th-Sm)/He thermochronology data from basement rocks from the margins of the north-south–trending Lokichar Basin that constrain the onset of rift-related cooling. Thermal history modeling of these data documents pronounced Eocene to Miocene denudational cooling of the basin-bounding Lokichar fault footwall. These results, along with ∼7 km of Paleogene to middle Miocene syn-rift strata preserved in the Lokichar fault hanging wall, suggest that formation of the Lokichar Basin began as early as ca. 45–40 Ma. Preexisting lithospheric heterogeneities inherited from earlier Mesozoic rifting and Eocene plume magmatism likely facilitated the broadly concurrent nucleation of strain in the Turkana Depression, up to ∼15 m.y. earlier than EARS initiation elsewhere. Late Paleogene extension in the Lokichar Basin and other parts of Turkana significantly predate the Miocene creation of pronounced plume-related topography in East Africa, suggesting that other mechanism(s), such as far-field stresses or mantle basal drag, likely played a critical role during EARS inception.
Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma
Authors: Chen Li , Huang Moli , Plummer Jasmine , Pan Jian , Jiang Yan Yi , Yang Qian , Silva Tiago Chedraoui , Gull Nicole , Chen Stephanie , Ding Ling Wen , An Omer , Yang Henry , Cheng Yulan , Said Jonathan W , Doan Ngan , Dinjens Winand NM , Waters Kevin M , Tuli Richard , Gayther Simon A , Klempner Samuel J , Berman Benjamin P , Meltzer Stephen J , Lin De-Chen , Koeffler H Phillip 
Published: August 2019

ObjectiveWhile oesophageal squamous cell carcinoma remains infrequent in Western populations, the incidence of oesophageal adenocarcinoma (EAC) has increased sixfold to eightfold over the past four decades. We aimed to characterise oesophageal cancer-specific and subtypes-specific gene regulation patterns and their upstream transcription factors (TFs). DesignTo identify regulatory elements, we profiled fresh-frozen oesophageal normal samples, tumours and cell lines with chromatin immunoprecipitation sequencing (ChIP-Seq). Mathematical modelling was performed to establish (super)-enhancers landscapes and interconnected transcriptional circuitry formed by master TFs. Coregulation and cooperation between master TFs were investigated by ChIP-Seq, circularised chromosome conformation capture sequencing and luciferase assay. Biological functions of candidate factors were evaluated both in vitro and in vivo.ResultsWe found widespread and pervasive alterations of the (super)-enhancer reservoir in both subtypes of oesophageal cancer, leading to transcriptional activation of a myriad of novel oncogenes and signalling pathways, some of which may be exploited pharmacologically (eg, leukemia inhibitory factor (LIF) pathway). Focusing on EAC, we bioinformatically reconstructed and functionally validated an interconnected circuitry formed by four master TFs—ELF3, KLF5, GATA6 and EHF—which promoted each other’s expression by interacting with each super-enhancer. Downstream, these master TFs occupied almost all EAC super-enhancers and cooperatively orchestrated EAC transcriptome. Each TF within the transcriptional circuitry was highly and specifically expressed in EAC and functionally promoted EAC cell proliferation and survival.ConclusionsBy establishing cancer-specific and subtype-specific features of the EAC epigenome, our findings promise to transform understanding of the transcriptional dysregulation and addiction of EAC, while providing molecular clues to develop novel therapeutic modalities against this malignancy.
Phase III, randomised, double-blind, multicentre study to evaluate the efficacy and safety of vonoprazan compared with lansoprazole in Asian patients with erosive oesophagitis
Authors: Xiao Yinglian , Zhang Shutian , Dai Ning , Fei Guijun , Goh Khean-Lee , Chun Hoon Jai , Sheu Bor-Shyang , Chong Chui Fung , Funao Nobuo , Zhou Wen , Chen Minhu 
Published: August 2019

ObjectiveTo establish the non-inferior efficacy of vonoprazan versus lansoprazole in the treatment of Asian patients with erosive oesophagitis (EO).DesignIn this phase III, double-blind, multicentre study, patients with endoscopically confirmed EO were randomised 1:1 to receive vonoprazan 20 mg or lansoprazole 30 mg, once daily for up to 8 weeks. The primary endpoint was EO healing rate at 8 weeks. The secondary endpoints were EO healing rates at 2 and 4 weeks. Safety endpoints included treatment-emergent adverse events (TEAEs).ResultsIn the vonoprazan (n=238) and lansoprazole (n=230) arms, 8-week EO healing rates were 92.4% and 91.3%, respectively (difference 1.1% (95% CI –3.822% to 6.087%)). The respective 2-week EO healing rates were 75.0% and 67.8% (difference 7.2% (95% CI –1.054% to 15.371%)), and the respective 4-week EO healing rates were 85.3% and 83.5% (difference 1.8% (95% CI –4.763% to 8.395%)). In patients with baseline Los Angeles classification grade C/D, 2-week, 4-week and 8-week EO healing rates were higher with vonoprazan versus lansoprazole (2 weeks: 62.2% vs 51.5%, difference 10.6% (95% CI –5.708% to 27.002%); 4 weeks: 73.3% vs 67.2%, difference 6.2% (95% CI –8.884 to 21.223); and 8 weeks: 84.0% vs 80.6%, difference 3.4% (95% CI –9.187% to 15.993%)). Overall, EO healing rates appeared higher with vonoprazan versus lansoprazole. TEAE rates were 38.1% and 36.6% in the vonoprazan and lansoprazole group, respectively.ConclusionOur findings demonstrate the non-inferior efficacy of vonoprazan versus lansoprazole in terms of EO healing rate at 8 weeks in this population. Safety outcomes were similar in the two treatment arms.Trial registration numberNCT02388724.
Prevalence of drug use during sex among swingers and perceived benefits and risks – a cross-sectional internet survey in the Netherlands
Authors: Evers Ymke J , Dukers-Muijrers Nicole H T M , Kampman Carolina J G , van Liere Geneviève A F S , Hautvast Jeannine L A , Koedijk Femke D H , Hoebe Christian J P A 
Published: August 2019

ObjectivesDrug use during sex has been associated with sexually transmitted infections (STI). While a growing body of research has investigated drug use during sex among men who have sex with men, data in swingers is limited. Swingers are heterosexual couples who have sex with others and singles who have sex with these couples. Our study assessed the prevalence of drug use during sex and perceived benefits and risks among swingers.MethodsIn 2018, 1005 swingers completed an online questionnaire that was advertised at Dutch swinger-websites. We assessed the associations between drug use during sex <6 months (any drug use excluding alcohol and erection medicines) and sociodemographic characteristics, alcohol use and condomless sex using backward multivariable logistic regression analysis. We compared drug use, motives, beliefs and experienced effects between heterosexual male, bisexual male and female drug-using swingers using χ2-tests.ResultsDrug use during sex was reported by 44% (443/1005): 51% in women, 44% in bisexual men and 39% in heterosexual men (P<0.01). Condomless vaginal (46%) and anal sex (22%) was higher in drug-using swingers (vs 34% and 13% in non-drug-using swingers, P<0.001). Among drug-using swingers, XTC (92%), GHB (76%) and laughing gas (69%) were mostly used. Prolonging sex (68%) and increasing arousal (66%) were the most reported motives. Most reported positive effects were feeling happy (78%) and increasing energy (78%). Ninety-four per cent considered drug use to be pleasurable. The most reported negative effect was feeling tired (53%), 7% reported that they might become addicted or felt uncomfortable having sex without drugs.ConclusionThis study among a large group of swingers shows that drug use during sex is highly prevalent. STI clinics should discuss drug use during sex among swingers and provide information on safer sex and drug use, while acknowledging the perceived benefits, such as the increased quality of sex.
Improved Ahead-of-time Compilation of Stack-based JVM Bytecode on Resource-constrained Devices
Authors: Reijers Niels , Shih Chi-Sheng 
Published: August 2019

Many virtual machines exist for sensor nodes with only a few kB RAM and tens- to a few hundred kB Flash memory. They pack an impressive set of features but suffer from a slowdown of one to two orders of magnitude compared to optimised native code, reducing throughput and increasing power consumption.
Compiling bytecode to native code to improve performance has been studied extensively for larger devices, but the restricted resources on sensor nodes mean most modern techniques cannot be applied. Simply replacing bytecode instructions with predefined sequences of native instructions is known to improve performance but produces code several times larger than the optimised C equivalent, limiting the size of programmes that can fit onto a device.
This article identifies the major sources of overhead resulting from this basic approach and presents optimisations to remove most of the remaining performance overhead, and over half the size overhead, reducing them to 67% and 77%, respectively. While this increases the size of the VM, the break-even point at which this fixed cost is compensated for by the smaller code it generates, is well within the range of memory available on a sensor device, allowing us to both improve performance and load more code on a device.
Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p
Authors: Xu Jie , Meng Qingtao , Li Xiaobo , Yang Hongbao , Xu Jin , Gao Na , Sun Hao , Wu Shenshen , Familiari Giuseppe , Relucenti Michela , Zhu Haitao , Wu Jiong , Chen Rui 
Published: August 2019

Abstract

Immune dysregulation plays a vital role in colorectal cancer initiation and progression. Long noncoding RNAs (lncRNA) exhibit multiple functions including regulation of gene expression. Here, we identified an immune-related lncRNA, MIR17HG, whose expression was gradually upregulated in adjacent, adenoma, and colorectal cancer tissue. MIR17HG promoted tumorigenesis and metastasis in colorectal cancer cells both in vitro and in vivo. Mechanistically, MIR17HG increased the expression of NF-κB/RELA by competitively sponging the microRNA miR-375. In addition, RELA transcriptionally activated MIR17HG in a positive feedback loop by directly binding to its promoter region. Moreover, miR-17-5p, one of the transcribed miRNAs from MIR17HG, reduced the expression of the tumor suppressor B-cell linker (BLNK), resulting in increased migration and invasion of colorectal cancer cells. MIR17HG also upregulated PD-L1, indicating its potential role in immunotherapy. Overall, these findings demonstrate that MIR17HG plays an oncogenic role in colorectal cancer and may serve as a promising therapeutic target.

Significance:
These findings provide mechanistic insight into the role of the lncRNA MIR17HG and its miRNA members in regulating colorectal cancer carcinogenesis and progression.