bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harvesting the Vibration Energy of BiFeO3 Nanosheets for Hydrogen Evolution
Authors: You Huilin , Wu Zheng , Zhang Luohong , Ying Yiran , Liu Yan , Fei Linfeng , Chen Xinxin , Jia Yanmin , Wang Yaojin , Wang Feifei , Ju Sheng , Qiao Jinli , Lam Chi‐Hang , Huang Haitao 
Published: June 2019

AbstractIn this study, mechanical vibration is used for hydrogen generation and decomposition of dye molecules, with the help of BiFeO3 (BFO) square nanosheets. A high hydrogen production rate of ≈124.1 μmol g−1 is achieved under mechanical vibration (100 W) for 1 h at the resonant frequency of the BFO nanosheets. The decomposition ratio of Rhodamine B dye reaches up to ≈94.1 % after mechanical vibration of the BFO catalyst for 50 min. The vibration‐induced catalysis of the BFO square nanosheets may be attributed to the piezocatalytic properties of BFO and the high specific surface area of the nanosheets. The uncompensated piezoelectric charges on the surfaces of BFO nanosheets induced by mechanical vibration result in a built‐in electric field across the nanosheets. Unlike a photocatalyst for water splitting, which requires a proper band edge position for hydrogen evolution, such a requirement is not needed in piezocatalytic water splitting, where the band tilting under the induced piezoelectric field will make the conduction band of BFO more negative than the H2/H2O redox potential (0 V) for hydrogen generation.
Cyclobis(7,8‐(para‐quinodimethane)‐4,4′‐triphenylamine) and Its Cationic Species Showing Annulene‐Like Global (Anti)Aromaticity
Authors: Dong Shaoqiang , Gopalakrishna Tullimilli Y. , Han Yi , Chi Chunyan 
Published: June 2019

Abstractπ‐Conjugated macrocycles containing all‐benzenoid rings usually show local aromaticity, but reported herein is the macrocycle CBQT, containing alternating para‐quinodimethane and triphenylamine units displaying annulene‐like anti‐aromaticity at low temperatures as a result of structural rigidity and participation of the bridging nitrogen atoms in π‐conjugation. It was easily synthesized by intermolecular Friedel–Crafts alkylation followed by oxidative dehydrogenation. X‐ray crystallographic structures of CBQT, as well as those of its dication, trication, and tetracation were obtained. The dication and tetracation exhibited global aromaticity and antiaromaticity, respectively, as confirmed by NMR measurements and theoretical calculations. Both the dication and tetracation possess open‐shell singlet ground states, with a small singlet–triplet gap.
Carbon black modified with 4‐hydroxymethylbenzenediazonium salt as filler for phenol‐formaldehyde resins and abrasive tools
Authors: Sandomierski Mariusz , Buchwald Tomasz , Strzemiecka Beata , Voelkel Adam 
Published: June 2019

ABSTRACTAlthough phenol‐formaldehyde (PF) resins possess excellent properties, they emit toxic substances during the decomposition of the crosslinking agent. Therefore, studies are being carried out on the fillers, which can reduce the amount of crosslinking agent. In this article, the synthesis of diazonium‐modified carbon black was conducted. Diazonium modification allows the effective incorporation of hydroxymethyl groups, which are responsible for the crosslinking of PF resins. Modified materials were used as active fillers in the PF composites and abrasive tools. Due to carbon modification, flexural strength increases 26% for PF resin composite and 1100% for abrasive tools. The increase is related to the resulting covalent bonds between the resin and the modified filler. Therefore, it can be stated that application of active filler improves the properties of novolac composites and abrasive tools. The use of this type of fillers may affect the reduction of the amount of crosslinking agent in the future. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48160.
Enhancing hemoglobin peptide production from chicken blood fermentation by food‐grade nonionic surfactant
Authors: Li Deng‐Long , Wu Bin , Zhang Xuan , Li Ming‐Yuan , Cheng Jing‐Rong , Tang Dao‐Bang 
Published: June 2019

AbstractThis study is focused on employing a potential process technology for enhancing hemoglobin peptides production from chicken blood. Effects of surfactants on chicken blood biodegradation and hemoglobin polypeptide accumulation were evaluated and the bioconversion conditions were optimized. Results suggested that surfactants exhibited the positive effect on hemoglobin peptides production during chicken blood bioconversion by Aspergillus niger. Dodecyl glucopyranoside was selected as the optimal surfactant and added at the 48th hour of the fermentation process (64 H) at the concentration of 6.0 g/L. Under the optimized conditions, 104.5 mg·N/mL amino nitrogen, 638.3 mg·N/mL nonprotein nitrogen, and 766.3 mg·N/mL soluble nitrogen were detected, which increased by approximately 0.7‐, 3.7‐, and 3.8‐fold, respectively, compared with the control. Furthermore, the acid protease stability was remarkably intensified and the accumulated peptides were mainly distributed at 500–2,000 Da. Results from this work corroborate the potential of applying dodecyl glucopyranoside in hemoglobin polypeptide production from chicken blood.
Simultaneous determination of N‐ethylpentylone, dopamine, 5‐hydroxytryptamine and their metabolites in rat brain microdialysis by liquid chromatography tandem mass spectrometry
Authors: Lin Zebin , Wang Hao , Hu Luyuyan , Li Jiaolun , Lin Junyi , Liu Baonian , Zhao Ziqin , Rao Yulan 
Published: June 2019

AbstractN‐Ethylpentylone (NEP) is a popular synthetic cathinone abused worldwide. To obtain more information about its pharmacokinetics and pharmacodynamics, a rapid, simple and sensitive liquid chromatography–tandem mass spectrometry method was developed for the determination of NEP, two important neurotransmitters, dopamine and serotonin, and their metabolites, including 3,4‐dihydroxyphenylacetic acid, 3‐methoxytyramine and 5‐hydroxyindole‐3‐acetic acid, in rat brain microdialysate. The analytes were separated on a Phnomenex Polar C18 column, with a mobile phase of 0.1% formic acid in water (A) and 0.1% formic acid in acetonitrile (B) under gradient elution to shorten the total chromatographic run time. A triple quadruple mass spectrometer coupled with an electrospray ionization source in both positive and negative ion mode was used to detect the analytes. This method showed excellent accuracy (87.4–113.5%) and precision (relative standard deviation <15%) at three quality control levels. The limits of detection were 0.2 ng/mL for NEP and 0.2–50 nm for the others and good linearity was obtained. This study pioneered a method to integrate exogenous drugs and endogenous neurotransmitters as the drugs act on the same determination system, which means that this innovation can provide support for further study of the addictive effects of NEP or other synthetic cathinones on extracellular levels of dopamine and 5‐hydroxytryptamine.
What do venture philanthropy organisations seek in social enterprises?
Authors: Leborgne‐Bonassié Marie , Coletti Michele , Sansone Giuliano 
Published: June 2019

AbstractVenture philanthropy organisations (VPOs) help social enterprises (SEs) to achieve social impact and economic sustainability. This paper aims at explaining why VPOs invest in SEs and how they select their investments. It is based on the case study of an international VPO: danone.communities. Our findings show that VPOs provide SEs with financial and nonfinancial support to tackle social challenges. In return, they acquire knowledge and improve their reputation. We discuss three main factors that VPOs seek when selecting their investments in SEs: the social value proposition of the SE, key resources and processes of both SE and VPO, and the synergies between them. Finally, we propose some criteria to assess such partnerships.
Impellent impeller—Switching intra‐aortic balloon pump to IMPELLA‐CP after ST‐segment elevation myocardial infarction and refractory cardiogenic shock
Authors: Contarini Marco , Costa Francesco , Garcia Ruiz Maria Victoria , Scalise Renato F. M. , De Velli Giovanni , Murè Paola , Mazzone Paolo , Sacchetta Giorgio , Andò Giuseppe 
Published: June 2019

AbstractCardiogenic shock is a dreadful complication of myocardial infarction. Despite widespread use and availability, intra‐aortic balloon pump (IABP) does not reduce mortality nor improves outcomes. Advanced mechanical circulatory support with IMPELLA system can substantially support hemodynamics and improve short‐term prognosis in patients with myocardial infarction and cardiogenic shock.
Global kernel estimator and test of varying‐coefficient autoregressive model
Authors: Lin Huazhen , Yang Baoying , Zhou Ling , Yip Paul S. F. , Chen Ying‐Yeh , Liang Hua 
Published: June 2019

AbstractWe propose a varying‐coefficient autoregressive model that contains additive models, varying‐ coefficient models, partially linear models and low‐dimensional interaction models as special cases. A global kernel backfitting method is proposed for the estimation and inference of parameters and unknown functions in this model. Key large‐sample results are established, including estimation consistency, asymptotic normality and the generalized likelihood ratio test for parameters and non‐parametric functions. The proposed methodology is examined by simulation studies and applied to examine the relationship between suicide news reports in the three leading newspapers and the daily number of suicides in Taiwan. The relationship between the media reporting and suicide incidence has been established and explored.The Canadian Journal of Statistics47: 487–519; 2019 © 2019 Statistical Society of Canada
Individualized prediction of leukemia‐free survival after autologous stem cell transplantation in acute myeloid leukemia
Authors: Shouval Roni , Labopin Myriam , Gorin Norbert C. , Bomze David , Houhou Mohamed , Blaise Didier , Zuckerman Tsila , Baerlocher Gabriela M. , Capria Saveria , Forcade Edouard , Huynh Anne , Saccardi Riccardo , Martino Massimo , Schaap Michel , Wu Depei , Mohty Mohamad , Nagler Arnon 
Published: June 2019

BackgroundAutologous stem cell transplantation (ASCT) is a potential consolidation therapy for acute myeloid leukemia (AML). This study was designed to develop a prediction model for leukemia‐free survival (LFS) in a cohort of patients with de novo AML treated with ASCT during their first complete remission.MethodsThis was a registry study of 956 patients reported to the European Society for Blood and Marrow Transplantation. The primary outcome was LFS. Multivariate Cox regression modeling with backward selection was used to select variables for the construction of the nomogram. The nomogram's performance was evaluated with discrimination (the area under the receiver operating characteristic curve [AUC]) and calibration.ResultsAge and cytogenetic risk (with or without FMS‐like tyrosine kinase 3 internal tandem duplication) were predictive of LFS and were used for the construction of the nomogram. Each factor in the nomogram was ascribed points according to its predictive weight. Through the calculation of the total score, the probability of LFS at 1, 3, and 5 years for each patient could be estimated. The discrimination of the nomogram, measured as the AUC, was 0.632 (95% confidence interval [CI], 0.595‐0.669), 0.670 (95% CI, 0.635‐0.705), and 0.687 (95% CI, 0.650‐0.724), respectively. Further validation with bootstrapping showed similar AUCs (0.629 [95% CI, 0.597‐0.657], 0.667 [95% CI, 0.633‐0.699], and 0.679 [95% CI, 0.647‐0.712], respectively), and this suggested that the model was not overfitted. Calibration was excellent. Patients were stratified into 4 incremental 5‐year prognostic groups, with the probabilities of LFS and overall survival ranging from 25% to 64% and from 33% to 79%, respectively.ConclusionsThe Auto‐AML nomogram score is a tool integrating individual prognostic factors to provide a probabilistic estimation of LFS after ASCT for patients with AML.
Frontiers in intravital multiphoton microscopy of cancer
Authors: Perrin Louisiane , Bayarmagnai Battuya , Gligorijevic Bojana 
Published: June 2019

AbstractBackgroundCancer is a highly complex disease, which involves the cooperation of tumor cells with multiple types of host cells and the extracellular matrix. Cancer studies that rely solely on static measurements of individual cell types are insufficient to dissect this complexity. In the last two decades, intravital microscopy has established itself as a powerful technique that can significantly improve our understanding of cancer by revealing the dynamic interactions governing cancer initiation, progression, and treatment effects in living animals. This review focuses on intravital multiphoton microscopy (IV‐MPM) applications in mouse models of cancer.Recent findingsIV‐MPM studies have already enabled a deeper understanding of the complex events occurring in cancer at the molecular, cellular, and tissue levels. Multiple cell types present in different tissues influence cancer cell behavior via activation of distinct signaling pathways. As a result, the boundaries in the field of IV‐MPM are continuously being pushed to provide an integrated comprehension of cancer. We propose that optics, informatics, and cancer (cell) biology are coevolving as a new field. We have identified four emerging themes in this new field. First, new microscopy systems and image processing algorithms are enabling the simultaneous identification of multiple interactions between the tumor cells and the components of the tumor microenvironment. Second, techniques from molecular biology are being exploited to visualize subcellular structures and protein activities within individual cells of interest and relate those to phenotypic decisions, opening the door for “in vivo cell biology”. Third, combining IV‐MPM with additional imaging modalities or omics studies holds promise for linking the cell phenotype to its genotype, metabolic state, or tissue location. Finally, the clinical use of IV‐MPM for analyzing efficacy of anticancer treatments is steadily growing, suggesting a future role of IV‐MPM for personalized medicine.ConclusionIV‐MPM has revolutionized visualization of tumor‐microenvironment interactions in real time. Moving forward, incorporation of novel optics, automated image processing, and omics technologies in the study of cancer biology, will not only advance our understanding of the underlying complexities but will also leverage the unique aspects of IV‐MPM for clinical use.
Bioequivalence of Ertugliflozin/Sitagliptin Fixed‐Dose Combination Tablets and Coadministration of Respective Strengths of Individual Components
Authors: Fediuk Daryl J. , Matschke Kyle , Liang Yali , Pelletier Kathleen B. , Wei Hua , Shi Haihong , Bass Almasa , Hickman Anne , Terra Steven G. , Zhou Susan , Krishna Rajesh , Sahasrabudhe Vaishali 
Published: June 2019

AbstractA fixed‐dose combination (FDC) tablet of ertugliflozin, a selective inhibitor of sodium‐glucose cotransporter 2, and sitagliptin, a dipeptidyl peptidase‐4 inhibitor, was developed for the treatment of patients with type 2 diabetes mellitus. Four studies were conducted under fasted conditions to demonstrate bioequivalence of ertugliflozin/sitagliptin FDC tablets and individual components at respective strengths when coadministered in healthy subjects. All studies had open‐label, randomized, 2‐period, 2‐sequence, single‐dose crossover designs. In each study 18 or 19 subjects were enrolled and received an ertugliflozin/sitagliptin FDC tablet (5 mg/50 mg, 5 mg/100 mg, 15 mg/50 mg, or 15 mg/100 mg) and corresponding strengths of ertugliflozin and sitagliptin coadministered as individual components. For both ertugliflozin and sitagliptin, the 90%CIs for the ratio (FDC:coadministration) of geometric means for area under the plasma concentration‐time profile from time 0 extrapolated to infinite time, and maximum observed plasma concentration, were within acceptance criteria for bioequivalence (80% to 125%). All adverse events were mild in intensity. The 4 studies demonstrated that each strength of FDC tablet is bioequivalent to the respective dose of coadministered individual components. This indicates that the known efficacy and tolerability of ertugliflozin and sitagliptin when coadministered can be translated to the use of a FDC formulation.
A novel infant cry recognition system using auditory model‐based robust feature and GMM‐UBM
Authors: Jiang Lin , Yi Yumei , Chen Defeng , Tan Ping , Liu Xingbao 
Published: June 2019

SummaryRecognizing infant cry is a meaning work, which can help new parent to understand infant's needs. Mostly, the motivation of existed recognition features is based on the psychoacoustic model. However, weak features are not enough to represent the details of infant cry. To address this issue, we propose a novel infant cry recognition system. In our system, the feature extraction method derived from auditory model, this model can address the auditory neural active representation. Additionally, we designed the intelligent system by a classifier named Gaussian Mixture Model‐Universal Background Model, which has a robust recognition performance to channel imbalance and corroded signal. The experiment results have shown a superior performance. Compared with the High‐order Spectral feature, a state‐of‐the‐art feature, when using Gaussian Mixture Model and General Background Model as classifier, the recognition accuracy improved by 14.6% and 13.7% under clear and corroded signal, respectively.
Boron‐Conjugated Pyrenes as Fluorescence‐Based Molecular Probes and Security Markers
Authors: Wakchaure Vivek Chandrakant , Das Tamal , Babu Sukumaran Santhosh 
Published: June 2019

AbstractBoron‐embedded aromatic hydrocarbons are a class of molecules known for their distinct electronic and/or optoelectronic properties and are thus suitable for many potential applications. Among those, boronic ester and acid containing molecules have been widely used for sensing and molecular recognition applications, respectively. We compared the sensing and molecular recognition properties of two boron‐containing pyrene derivatives for fluoride and glucose sensing applications. The presence of four boronate ester groups enabled fluoride ion sensing at the μM level. The boronic acid derivative is very selective towards glucose compared to other saccharides. Furthermore, we used the mechano‐responsive fluorescence changes and self‐assembly of these derivatives, respectively, for fluorescence‐based inkless and ink (water)‐based writing in invisible security labeling applications.
RAT selection for a low battery mobile device for future 5G networks
Authors: Adiwal Manisha , Singh Niraj Pratap 
Published: June 2019

SummaryThe growth of wireless communication toward fifth generation will lead to the existence of number of access technologies to provide seamless connectivity and form heterogeneous network environment. Earlier, there was single access technology to run applications, but 5G will have heterogeneous network environment and provide separate network for each application. As compared with 4G, 5G will provide increase in data rate, decrease in delay, increase in quality of service, and so on because of its various enabling technologies. Therefore, for each application, selection of best access network via its enabling technology is an important task. This selection is done either at user terminal side or at network operator side by combining preferences for network attributes and network parameters. In this paper, to enjoy 5G, selection is done in a heterogeneous networks environment for enabling technologies like device‐to‐device communication, spectrum sharing, enhancing quality of experience, energy efficiency, and so on. This selection is done via optimization techniques for a fixed duration video clip that is to be transmitted from a device running low in battery. The selection environment composed of UMTS, WLAN1, and WLAN2 as available networks. The simulation results show that the network selected for each enabling technology supports various features of 5G. Also, error analysis of selection results is done using confidence interval estimate at 90%, 92%, and 95% confidence level. From results obtained, it is seen that different optimization techniques used to access network for different enabling technologies (providing 5G features) prove to be useful for future 5G network.
Fine‐needle aspiration of adrenal lesions: A 20‐year single institution experience with comparison of percutaneous and endoscopic ultrasound guided approaches
Authors: Novotny Aaron G. , Reynolds Jordan P. , Shah Akeesha A. , Bhatt Amit , Chahal Prabhleen , Remer Erick M. , Stevens Tyler , Gmitro Stephen , Sturgis Charles D. 
Published: June 2019

AbstractBackgroundHistorically, sampling of adrenal lesions has been performed by percutaneous image‐guided fine‐needle aspiration (FNA) biopsy. Endoscopic ultrasound guided (EUS)‐FNA of the adrenals was first employed at Cleveland Clinic ~10 years ago. We report a two‐decade experience of adrenal FNA in our institution.MethodsAn electronic retrieval identified adrenal FNAs from 1997 to 2017. Data points from each case (diagnosis, method of FNA, age, sex, laterality, needle gauge, size of lesion, adequacy of sample, and histologic follow up) were analyzed.ResultsOur retrieval confirmed 198 adrenal FNAs performed over 20 years. Of these, 90% (179/198) were percutaneous, and the remaining 10% (19/198) were collected by EUS. Of the 179 CT guided FNAs, 93% (162/179) yielded an adequate specimen as compared with an adequacy rate of 89% (17/19) for EUS‐FNAs, with no significant difference in adequacy rates by collection method, P = .64 (Fisher's exact). Of all adrenal FNAs, 53% (105/198) confirmed metastases, 33% (65/198) showed adrenal cells or primary adrenal neoplasms (85% cortical cells, 14% cortical neoplasia, 1% pheochromocytoma), 8% were inadequate (15/198), 3% were atypical (7/198), and 2% were suspicious for malignancy (5/198).ConclusionFNA of the adrenal glands can be useful in the diagnosis and staging of metastatic neoplasms, as well as in distinguishing primary adrenal cortical from medullary neoplasms and characterizing hematolymphoid and mesenchymal neoplasms. Overall adequacy rates for adrenal cytology are high (92%) with no statistically significant difference between CT‐guided (93%) and EUS‐FNA adequacy (89%). The majority of our procedures confirmed metastases, sparing patients unnecessary surgery.