bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microelectromechanical system‐based biocompatible artificial skin phantoms
Authors: Liu Chien‐Hao , Huang Yin‐Chen , Li Shang‐Hsuan , Chen Yen‐An , Wang Wesley Z , Yu Jia‐Shing , Shih Wen‐Pin 
Published: December 2018

Revealing the physical interactions between biomedical devices and human skin requires a scalable phantom with physical properties as close as possible to those of human skin. In this work, the authors developed an artificial phantom for the simulation of human skin. The proposed device comprises a gelatin membrane, a layer of SU‐8 photoresist, and microholes, respectively, mimicking the epidermis, stratum corneum, and sweat pores/ducts. A prototype was fabricated using microelectromechanical system and laser ablation techniques. The proposed structure includes microholes with a diameter of 20 µm and a depth of 57 µm distributed at a surface density of 620/cm2 to simulate pores and sweat ducts. The mechanical and electrical properties of the fabricated phantom were compared with those of human skin. The electrical properties, such as resistivity and impedance, can be adjusted simply by varying the content of sodium chloride. 3T3 cells cultivated on the artificial phantom demonstrate their biocompatibility. The authors believe that the proposed phantom model and associated manufacturing scheme could be used to facilitate the testing of wearable and attachable bioelectronic devices.
Glucose biosensor using fluorescence quenching with chitosan‐modified graphene oxide
Authors: Li Wenjun , Jiang Tingting , Pu Yang , Jiao Xudong , Tan Wenqiang , Qin Song 
Published: December 2018

A novel graphene oxide (GO) nanomaterial, which was rapidly and simply synthesised and conjugated with low‐molecular‐weight chitosan (CS), was used to develop a simple, sensitive GO biosensor system for glucose detection by fluorescence resonance energy transfer. The GO‐CS was used to detect low concentrations of glucose based on competitive binding with maltose‐binding protein (MBP). The α‐subunit of recombinant phycocyanin (rPC), which emits far‐red fluorescence, was used to label MBP (MBP‐rPC). The rPC emission was quenched by binding between GO‐CS and MBP. However, in the presence of glucose, GO‐CS was out‐competed for binding to MBP, leading to rPC fluorescence. Glucose was sensitively and selectively detected with this biosensor, with a linear detection range of 0.1–1 mg glucose/ml. The limit of detection for glucose was ∼0.05 mg/ml.
Trees with equal Roman {2}-domination number and independent Roman {2}-domination number
Authors: Wu Pu , Li Zepeng , Shao Zehui , Sheikholeslami Seyed Mahmoud 
Published: December 2018

A Roman {2}-dominating function (R{2}DF) on a graph G =(V, E) is a function f : V → {0, 1, 2} satisfying the condition that every vertex u for which f(u) = 0 is adjacent to either at least one vertex v with f(v) = 2 or two vertices v1, v2 with f(v1) = f(v2) = 1. The weight of an R{2}DF f is the value w(f) = ∑u∈Vf(u). The minimum weight of an R{2}DF on a graph G is called the Roman {2}-domination number γ{R2}(G) of G. An R{2}DF f is called an independent Roman {2}-dominating function (IR{2}DF) if the set of vertices with positive weight under f is independent. The minimum weight of an IR{2}DF on a graph G is called the independent Roman {2}-domination number i{R2}(G) of G. In this paper, we answer two questions posed by Rahmouni and Chellali.
Wegen Unterzucker wurden schon Kriege
begonnen!
Authors: Hertlein Margit 
Published: December 2018

ZusammenfassungWas sorgt dafür, dass unser Stammhirn die Macht übernimmt und wir „zum Tier
werden“? Urtriebe? Inwieweit diese uns heute noch leiten und was Sie als
Führungskraft tun können, um nicht die Keule zu schwingen, erfahren Sie im
zweiten Teil unserer Artikelreihe.
Erfolg als Summe aller Teile
Authors: Post Margarete 
Published: December 2018

ZusammenfassungDer Personalmangel in der Pflege ist das Thema, wenn es um die Pflege
alter und kranker Menschen in der Zukunft geht. Viele Einrichtungen werben seit
einiger Zeit mehr oder weniger offensiv ausländische Pflegekräfte an. Zudem gibt
es Überlegungen, Flüchtlinge für den Pflegeberuf zu gewinnen.
Lean Management
Authors: Küppers Axel 
Published: December 2018

ZusammenfassungKeine Frage, im Pflegebereich ticken die Uhren anders als in der Industrie. Wer
im Krankenhaus Lean Management verordnet, muss im Hinterkopf behalten, dass der
Mensch im Vordergrund steht. Nicht alle Kliniken schaffen den Spagat zwischen
Patientenzuwendung und Effizienz. Allzu häufig gilt: Im Kopf die Zahl,
im Bauch das Gefühl – im Herzen Verwirrung. Doch es gibt Ausnahmen.
Association between Caffeine Consumption in Pregnancy and Low Birth Weight and Preterm Birth in the birth Cohort of Ribeirão Preto
Authors: Vitti Fernanda Pino , Grandi Carlos , Cavalli Ricardo de Carvalho , Simões Vanda Maria Ferreira , Batista Rosângela Fernandes Lucena , Cardoso Viviane Cunha 
Published: December 2018

Objective To describe caffeine consumption during pregnancy and its association with low birth weight (LBW) and preterm birth in the birth cohort of Ribeirão Preto, state of São Paulo, Brazil, in 2010.
Methods Cohort study, with descriptive and analytical approach. Data included 7,607 women and their newborns in Ribeirão Preto, state of São Paulo, Brazil. The women answered standardized questionnaires about reproductive health, prenatal care, life habits, sociodemographic conditions, and information about coffee intake. The independent variable was high caffeine consumption (≥300 mg/day) from coffee during pregnancy, and the dependent variables were LBW (birth weight < 2,500 g) and preterm birth (< 37 weeks of gestational age). Four adjusted polytomous logistic regression models, relative risk (RR) and 95% confidence interval (CI) were fitted: biological and sociodemographic conditions; obstetric history; current gestational conditions; and all variables included in the previous models.
Results A total of 4,908 (64.5%) mothers consumed caffeine, 143 (2.9%) of whom reported high consumption. High caffeine intake was significantly associated with reduced education and with the occupation of the head of the family, nonwhite skin color, not having a partner, higher parity, previous abortion and preterm birth, urinary tract infection, threatened abortion, alcohol consumption and smoking. No association was found between high caffeine consumption and LBW or preterm birth in both unadjusted (RR = 1.45; 95% CI: 0.91–2.32; and RR = 1.16; 95% CI: 0.77–1.75, respectively) and adjusted analyses (RR = 1.42; 95% CI: 0.85–2.38; and RR = 1.03; 95% CI: 0.65–1.63, respectively).
Conclusion In this cohort, high caffeine intake was lower than in other studies and no association with LBW or preterm birth was found.
Anatomical Study of the Superficial Palmar Arch, its Relation to the Kaplan Cardinal Line and Literature Review
Authors: Arroyo Berezowsky Claudia , Gutiérrez Alejandro , Fresnedo Jimena , Montero José 
Published: December 2018

Introduction The superficial palmar arch is the main contributor to the vascular supply of the hand. Numerous anatomical variants have been described and there are multiple classifications of the superficial palmar arch available. The Kaplan cardinal line is used occasionally as a reference to identify the deep structures of the hand. However, there are also multiple variants of the line and multiple reports regarding the structures that can be identified with it.
Material and Methods Ten anatomical dissections of hands were performed in seven cadaveric specimens. The anatomical variants of the superficial palmar arch were recorded, as well as their relationship with the Kaplan cardinal line. A review of the available literature was made.
Results According to the classification by Coleman et al, the most common type was the complete superficial palmar arch, present in seven hands, while the incomplete superficial palmar arch was found in three hands. The most frequent complete palmar arch was type IB, followed by type IIB, and finally type IA and type IIA. The most common relation was with the Kaplan cardinal line type A to the apex of the arch and with type B to the curvature of the ulnar artery.
Conclusions There is a great anatomical variability in the superficial palmar arch. There was a greater frequency of the complete superficial palmar arch, with the ulnar artery being the dominant vascular supply. The Kaplan cardinal line can be used as a safety limit to avoid the superficial palmar arch if it is drawn to intersect the pisiform bone.
Clinical Relevance It is important to be aware of the anatomical variants of the superficial palmar arch, as well as of its relationship with the superficial structures of the hand to be able to perform invasive or reconstructive procedures and to preserve the vascularity of the hand.
Noncoding RNA in Cholangiocarcinoma
Authors: Salati Massimiliano , Braconi Chiara 
Published: December 2018

AbstractCholangiocarcinomas (CCAs) are tumors with a dismal prognosis. Early diagnosis is a key challenge because of the lack of specific symptoms, and the curability rate is low due to the difficulty in achieving a radical resection and the intrinsic chemoresistance of CCA cells. Noncoding RNAs (ncRNAs) are transcripts that are not translated into proteins but exert their functional role by regulating the transcription and translation of other genes. The discovery of the first ncRNA dates back to 1993 when the microRNA (miRNA) lin-4 was discovered in Caenorhabditis elegans. Only 10 years later, miRNAs were shown to play an oncogenic role in cancer cells and within 20 years miRNA therapeutics were tested in humans. Here, the authors review the latest evidence for a role for ncRNAs in CCA and discuss the promise and challenges associated with the introduction of ncRNAs into clinical practice.
Impacts of Cytochrome P450 2D6 (CYP2D6) Genetic Polymorphism in Tamoxifen Therapy for Breast Cancer
Authors: Bezerra Lucas Soares , Santos-Veloso Marcelo Antônio Oliveira , Bezerra Junior Natanael da Silva , Fonseca Lucilia Carvalho da , Sales Wivianne Lisley Andrade 
Published: December 2018

AbstractTamoxifen (TMX) is the main drug used both in pre and postmenopausal women as adjuvant treatment for hormone receptor-positive breast cancer. An important barrier to the use of TMX is the development of drug resistance caused by molecular processes related to genetic and epigenetic mechanisms, such as the actions of cytochrome P450 2D6 (CYP2D6) polymorphisms and of its metabolites. The present study aimed to review recent findings related to the impact of CYP2D6 polymorphisms and how they can affect the results of TMX in breast cancer treatment. The keywords CYP2D6, tamoxifen, and breast cancer were searched in the PubMed, Scopus, The Cochrane Library, Scielo, and Bireme databases. Studies related to other types of neoplasms or based on other isoenzymes from cytochrome P450, but not on CYP2D6, were excluded. The impact of CYP2D6 polymorphisms in the TMX resistance mechanism remains unclear. The CYP2D6 gene seems to contribute to decreasing the efficacy of TMX, while the main mechanism responsible for therapy failure, morbidity, and mortality is the progression of the disease.
Vorsicht ist besser als Nachsicht
Authors: Landzettel Nicolai 
Published: December 2018

ZusammenfassungProblem erkannt, Problem gebannt? Vielen Kliniken ist wohl bewusst, dass es
eine Sicherheitslücke in der IT gibt, aber die Budgets sind knapp.
Warum Sie sich dem Thema trotzdem widmen sollten, bevor es zur Cyber-Attacke
kommt, lesen Sie im folgenden Beitrag.
Hacked – eine neue Form des Virusinfekts
Authors: Schwarz Simone 
Published: December 2018

ZusammenfassungRien ne va plus – nichts geht mehr –, zumindest nichts, was mit Computern zu tun
hat. Wie sehr wir heutzutage auf die Technik angewiesen sind, hat das
Lukaskrankenhaus Neuss jäh am eigenen Leibe erfahren müssen. Lesen Sie mehr über
die Cyber-Attacke, die sich bis heute auswirkt.
The Physiologus and the Greek Papyri
Authors: Stroppa Marco 
Published: December 2018

In Greek literary papyri coming from Egypt we can find only a few evidences of works about animals, for example fragments of Aristotelian works or works linked to the scientific production. Only in recent years two papyri were published that contained a “bestiary” in a broad sense.
The first papyrus is a fragment of the Physiologus, one of the most important ancient Greek treatises devoted to the animals: it is a fragment small in size, but of great importance since it testifies the spreading of this work.
The second papyrus full of animal figures is the so-called Artemidorus Papyrus, which on one side bears the drawings of many animals. In some cases it is possible to trace them back to the animals described in the chapters of the Physiologus, and determine connections between such different products, an illustrated scroll belonging to the first century AD and a Christian essay of the third century AD.
Parental sport achievement and the development of athlete expertise
Authors: Wilson Stuart G. , Wilson Melissa J. , Baker Joseph 
Published: December 2018

AbstractThis study sought to examine how parental sport involvement and attainment were related to the eventual level of competitive sport attained by their children. Athletes (n = 229) were divided into three skill level groups (elite: n = 139; pre‐elite: n = 33; non‐elite: n = 57), based on the peak competition level achieved in their career, which were compared using chi‐squares tests of independence and analyses of variance according to parents sport characteristics provided through the Developmental History of Athletes Questionnaire. Parental recreational and competitive sport participation was overrepresented among elite athletes, as were parents who reached an elite level of sport themselves. Results were found to differ according to parent sex, with athlete skill level significantly related to the sport participation and skill level of fathers, but not mothers. Results suggest parental sport experiences at different levels of competition influence the development of athletes, although these relationships are subject to many factors.
ANPELA: analysis and performance assessment of the label-free quantification workflow for metaproteomic studies
Authors: Tang Jing , Fu Jianbo , Wang Yunxia , Li Bo , Li Yinghong , Yang Qingxia , Cui Xuejiao , Hong Jiajun , Li Xiaofeng , Chen Yuzong , Xue Weiwei , Zhu Feng 
Published: December 2018

Abstract
Label-free quantification (LFQ) with a specific and sequentially integrated workflow of acquisition technique, quantification tool and processing method has emerged as the popular technique employed in metaproteomic research to provide a comprehensive landscape of the adaptive response of microbes to external stimuli and their interactions with other organisms or host cells. The performance of a specific LFQ workflow is highly dependent on the studied data. Hence, it is essential to discover the most appropriate one for a specific data set. However, it is challenging to perform such discovery due to the large number of possible workflows and the multifaceted nature of the evaluation criteria. Herein, a web server ANPELA (https://idrblab.org/anpela/) was developed and validated as the first tool enabling performance assessment of whole LFQ workflow (collective assessment by five well-established criteria with distinct underlying theories), and it enabled the identification of the optimal LFQ workflow(s) by a comprehensive performance ranking. ANPELA not only automatically detects the diverse formats of data generated by all quantification tools but also provides the most complete set of processing methods among the available web servers and stand-alone tools. Systematic validation using metaproteomic benchmarks revealed ANPELA’s capabilities in 1 discovering well-performing workflow(s), (2) enabling assessment from multiple perspectives and (3) validating LFQ accuracy using spiked proteins. ANPELA has a unique ability to evaluate the performance of whole LFQ workflow and enables the discovery of the optimal LFQs by the comprehensive performance ranking of all 560 workflows. Therefore, it has great potential for applications in metaproteomic and other studies requiring LFQ techniques, as many features are shared among proteomic studies.
1258. The Eyes Have It: Investigating a Cluster of Non-lactose Fermenting Gram-Negative Bacilli From Donor Corneal Rim Tissue
Authors: Olson Christopher , Schomer Kathleen , Pisney Larissa , Barron Michelle 
Published: December 2018

Abstract

Background
Following corneal transplant, donor corneal rim tissue are sometimes cultured to help predict the risk of post-keratoplasty endophthalmitis. In July 2016, the Infection Control (IC) team was notified by the microbiology laboratory of three donor corneal rim cultures growing non-lactose fermenting (NLF) Gram-negative bacilli, which was unusual for this type of specimen. The IC team initiated an epidemiological outbreak investigation to determine the source of the NLF Gram-negative bacilli.

Methods
A 12-month retrospective review of donor corneal rim cultures was performed from July 2015 to July 2016, with continual prospective monitoring of donor corneal rim cultures. The protocols used to prepare corneal donor tissues were reviewed. The standard protocol included flooding the tissue with povidone iodine followed by rinsing with a sterile saline solution and then placement in a sterile container with Opitsol GS (a preservative solution with gentamycin and streptomycin). The sterile saline rinse that was normally used for processing had been on back order and had been replaced with an alternative brand from March 2016 to July 2016. Unopened bottles of the alternative brand of sterile saline fluid and Optisol GS were sent to an outside laboratory for bacterial culture and remaining product was temporarily quarantined.

Results
Microbiology review revealed seven donor corneal rim cultures positive for NLF Gram-negative bacilli from May to July 2016. Organisms isolated from the donor corneal rim tissue included Achromobacter xylosoxidans (4), Burkholderia cepacia (3), Stenotrophomonas maltophilia (2), and Elizabethkingia meningoseptica (1). Sterility cultures of Opitsol GS demonstrated no growth. Sterility cultures of the sterile saline rinse grew Gram-positive and -negative bacteria from all samples. A FDA MedWatch was submitted in July 2016, and on September 6, 2016 an FDA recall notice was published. The quarantined saline was permanently removed. No clinical infections associated with the positive donor corneal rim cultures were identified.

Conclusion
Microbiologists are the front line for IC surveillance. Close partnership between the IC team and the microbiology laboratory can help identify potential outbreaks by alerting them of the growth of atypical organisms or clusters.

Disclosures
All authors: No reported disclosures.
1041. How Do Healthcare Providers Approach Empiric β-Lactam (BL) Treatment of Bloodstream Infections (BSI) Caused by Gram-Negative Rods (GNRs)? Analysis of Escherichia coli and Klebsiella pneumoniae BSI From the Veterans Health Administration (VHA)
Authors: Viau Roberto , Wilson Brigid , Evans Scott R , Perez Federico , Chambers Henry F , Fowler Vance G , Kreiswirth Barry N , Bonomo Robert A ,   ARLG
Published: December 2018

Abstract

Background
Physicians make decisions regarding antimicrobial chemotherapy based on clinical and demographic factors, choosing initial empiric therapy without knowing the pathogen or its susceptibilities. Given the various treatment options and resistance mechanisms, treatment of GNR BSI is challenging with 30 day mortality approaching 30%. Using a large cohort of Escherichia coli and Klebsiella pneumoniae BSI, we aimed to characterize empiric antibiotic therapy, comparing treatment before and after Gram stain (GS) results, and summarize clinical outcomes.

Methods
Using a cohort of patients hospitalized within VHA, we used the Corporate Data Warehouse to identify blood cultures positive for E. coli or K. pneumoniae from 2006 to 2015. We extracted inpatient antimicrobial regimens, demographics, and antibiotic susceptibility testing (AST) results. We excluded cases with missing GS result dates and those not treated with BLs. We defined “initial” empiric treatment as agents received between specimen collection and GS results; and “modified” empiric treatment as agents received after GS but before AST results. Patient characteristics, treatments, and outcomes were summarized overall and by organism.

Results
Of 36,531 BSI identified, we analyzed a subset of 21,597 that met our inclusion criteria (figure). Within this subset of patients, the mean age was 70.3 and all-cause 30-day mortality was 13.9% (2,054 out of 14,735) for E. coli and 17.8% (1,220 out of 6,862) for K. pneumoniae. Initial empiric treatment included an effective agent in 90.4% (91.2% in E. coli, 88.7% in K. pneumoniae) of cases. This rate increased to 95.3% (96.0% in E. coli, 93.8% in K. pneumoniae) for modified empiric treatment. The most commonly prescribed initial empiric BL was piperacillin/tazobactam, observed in 55% of treated patients, followed by ceftriaxone and cefepime in 14% and 11% of treated patients, respectively. Carbapenems were included in 8% of initial and 13% of modified empiric treatments.

Conclusion
In this cohort of older patients with E. coli and K. pneumoniae BSI, higher rates of effective BL empiric treatment were achieved after GS results. BL empiric regimens consisted mostly of broad-spectrum agents. These observations highlight the potential utility of a diagnostic tool available shortly after specimen collection to inform treatment and improve patient outcomes.

Disclosures
All authors: No reported disclosures.
Replicating Anomalies
Authors: Hou Kewei , Xue Chen , Zhang Lu 
Published: December 2018

AbstractMost anomalies fail to hold up to currently acceptable standards for empirical finance. With microcaps mitigated via NYSE breakpoints and value-weighted returns, 65% of the 452 anomalies in our extensive data library, including 96% of the trading frictions category, cannot clear the single test hurdle of the absolute $t$-value of 1.96. Imposing the higher multiple test hurdle of 2.78 at the 5% significance level raises the failure rate to 82%. Even for replicated anomalies, their economic magnitudes are much smaller than originally reported. In all, capital markets are more efficient than previously recognized.Received June 12, 2017; editorial decision October 29, 2018 by Editor Stijn Van Nieuwerburgh. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.