bluuebunny/crossref_metadata_2025_split huggingface dataset:
La technique qui donne confiance
Authors: Fournier Emmanuel 
Published: July 2019

Faut-il craindre la technique comme un monstre qui dévorerait notre être et qui nous éloignerait du souci de nous-mêmes, en nous réduisant à ne plus être que ses objets ? Faut-il la craindre tout particulièrement pour la médecine qui se donne en confiance aux appareils et aux calculs, sans toujours imaginer à quelle opération de réduction, elle risque, ce faisant, de livrer malades et maladies ? Mais la technique n’est-elle pas d’abord un geste de notre part, un geste provisoire que nous faisons vers nous-mêmes, aussi maladroit puisse-t-il paraître ? Ce geste, l’avons-nous achevé ? Sommes-nous sûrs du sens et de la suite que nous voulons lui donner ? Parmi tous les lieux de technique en médecine qui appellent à réenvisager ces questions, il y en a un emblématique, celui de l’imagerie cérébrale, avec sa prétention à dire notre intimité, sa réalité de faiseuse d’images et notre jouissance à en nourrir notre imaginaire. Devons-nous être dupes ? Ne pouvons-nous voir la technique comme un moyen, non de nous figer, mais de nous chercher et de nous dépasser ? Un moyen de nous révéler, une confiance que nous nous donnons pour cette entreprise ?
Vue d’ensemble des conflits de distribution écologique en Inde
Authors: Roy Brototi , De Roo Priscilla 
Published: July 2019

Cet article présente une revue des mouvements de justice environnementale en Inde, à partir d’une combinaison d’informations provenant de l’Atlas de la justice environnementale (EJAtlas), de travaux de terrain et d’une analyse de la littérature secondaire. L’auteur souligne ici l’intensité des conflits, les armes judiciaires qui confortent les manifestations et le changement des slogans avec le temps, ainsi que les synergies et les alliances anciennes et actuelles entre ces mouvements indiens. Pour l’analyse sont combinés l’utilisation de statistiques descriptives et quelques exemples concrets. Enfin, il est proposé un débat sur la signification du terme « succès » appliqué à la justice environnementale, sujet sur lequel des recherches plus approfondies s’avèrent nécessaires.
Face à la croissance verte
Authors: Ávila Sofía , Rao Siddharth , Querrien Anne 
Published: July 2019

L’utilisation des énergies renouvelables en Inde est en train de modifier (ou de maintenir) le modèle de croissance et de développement inégal qui la caractérise comme « économie émergente ». Nous mettons l’accent sur deux processus contrastés que connait l’Anantapuramu, un district rural marqué par des indices de pauvreté et de vulnérabilité climatique élevés. D’un côté, le développement de méga-infrastructures d’énergie éolienne déclenche une transformation régionale en faveur de « l’industrialisation verte ». De l’autre, la résistance du Collectif Timbaktu, une organisation de base qui travaille à la régénération des terres communales « improductives », promeut la gestion collective des ressources et renforce les relations de coopération au sein des communautés locales. Cette perspective contrastée permet de mettre à jour les différentes façons de comprendre la durabilité et ses implications politiques dans les dynamiques écologiques, sociales et spatiales des territoires concrets.
Pérenniser la gouvernance démocratique dans une organisation fondée sur un projet socio-politique. Étude du cas de la société coopérative et participative Ardelaine
Authors: Juban Jean-Yves 
Published: July 2019

Une entreprise peut être fondée à la fois sur un projet économique et un projet socio-politique. La part de chaque projet est variable, il est rare que le projet socio-politique soit dominant, encore plus rare qu’il le reste durablement au cours de la vie de l’entreprise. Notre objectif est d’apporter des éléments de réponse à la problématique de la gouvernance démocratique de l’entreprise. A partir du cas de la société coopérative et participative (SCOP) Ardelaine, nous nous intéressons aux conditions à réunir pour qu’un projet fondé sur des idéaux démocratiques puisse être pérenne. Notre grille d’analyse est celle de trois pouvoirs de gouvernance selon Gomez (2018) : souverain, exécutif et de surveillance. Dans le cas étudié, le pouvoir souverain est exercé par le conseil d’administration, le pouvoir exécutif incombe au comité de direction, et le pouvoir de surveillance se révèle difficile à exercer pour des salariés sociétaires qui sont invités à participer aux prises de décision stratégiques. Le projet territorial de la SCOP, à l’origine de celle-ci, assure l’équilibre et la liaison entre les aspirations à la justice sociale et à la démocratie d’une part, et un projet économique viable d’autre part.
Indian guidelines on imaging of the small intestine in Crohn’s disease: A joint Indian Society of Gastroenterology and Indian Radiology and Imaging Association consensus statement
Authors: Kedia Saurabh , Sharma Raju , Makharia Govind , Ahuja Vineet , Desai Devendra , Kandasamy Devasenathipathy , Eapen Anu , Ganesan Karthik , Ghosha Uday C , Kalra Naveen , Karthikeyan R , Madhusudhan Kumble Seetharama , Philip Mathew , Puri Amarender , Puri Sunil , Sinha Saroj K , Banerjee Rupa , Bhatia Shobna , Bhat Naresh , Dadhich Sunil , Dhali G K , Goswami B D , Issar S K , Jayanthi V , Misra S P , Nijhawan Sandeep , Puri Pankaj , Sarkar Avik , Singh S P , Srivastava Anshu , Abraham Philip , Ramakrishna B S 
Published: July 2019

AbstractThe Indian Society of Gastroenterology (ISG) Task Force on Inflammatory Bowel Disease and the Indian Radiological and Imaging Association (IRIA) developed combined ISG-IRIA evidence-based best-practice guidelines for imaging of the small intestine in patients suspected to have or having Crohn’s disease. The 29 consensus statements, developed through a modified Delphi process, are intended to serve as reference for teaching, clinical practice, and research.
Pharmacovigilance in India and its Impact in Patient Management
Authors: Singh Narinder , Sharma Geeta , Kumar Rahat , Bhandari Vikram 
Published: July 2019

ABSTRACT
Pharmacovigilance is the pharmacological science relating to the detection, assessment, understanding, and prevention of adverse effects, particularly the long-term and short-term adverse effects of drugs or treatment. The World Health Organization (WHO) established pharmacovigilance Programme for International Drug Monitoring in response to the thalidomide disaster detected in 1961. India joined the WHO adverse drug reaction (ADR) monitoring program based in Uppsala, Sweden, in 1998. The Central Drugs Standard Control Organization (CDSCO), Directorate General of Health Services, under the aegis of the Ministry of Health and Family Welfare, Government of India, in collaboration with Indian Pharmacopoeia Commission, Ghaziabad, is a National Coordinating Centre (NCC). Adverse drug reaction monitoring centers (AMCs) under the Pharmacovigilance Programme of India (PvPI) play a vital role in the collection and follow-up of ADR reports from the patients, as drug trials in animals and humans (Phase I–III) do not predict accurately the adverse drug events. Patients with chronic kidney disease (CKD)/liver disease are at risk of enhanced drug-related events. These patients should be closely monitored for any adverse events and it should be reported. Thus, inculcating the habit of ADR reporting will help in generating data specific to Indian population and will contribute toward patient safety. This will also help in modifying the treatment given to the patients, as early identification of ADRs will help in reducing morbidity and mortality in patients.

How to cite this article
Sharma G, Kumar R, Singh J, Bhandari V, Singh N. Pharmacovigilance in India and its Impact in Patient Management. Curr Trends Diagn Treat 2017;1(1):27-33.
The nomenclature and type locality of Berkeleya adeliensis (Bacillariophyceae): a correction
Authors: Medlin Linda K. 
Published: July 2019

Background and aims – Berkeleya adeliensis was described in 1990 by Medlin, unfortunately with an error in its typification. This note discusses and corrects the error.
Key results and conclusions – The type locality is in McMurdo Sound, Antarctica, not in Adélie Land where the species was first recorded by Manguin as “Amphipleura rutilans var. antarctica”. Nevertheless, the species does occur in both localities, as shown by published illustrations. Morphometric data are given for Berkeleya species reported from the Antarctic, including the two locations where B. adeliensis occurs.
Restoring degraded ecosystems through the biowaste application: Stability of agreggates, infiltration and vegetation cover
Authors: Hueso González Paloma , Martínez-Murillo Juan Francisco , Ruíz-Sinoga José Damián 
Published: July 2019

La transición hacia una economía circular, en la que los recursos se conserven y se reduzca la generación de residuos, es una necesidad real para lograr una economía sostenible. Dentro de ella, cobra particular importancia la gestión de los residuos orgánicos o bioresiduos, tanto por la cantidad que suponen como por las implicaciones ambientales de su mala gestión. El objetivo de este estudio es evaluar los efectos de los bioresiduos como técnicas de restauración en paisajes forestales mediterráneos degradados. Para el mismo, se utilizan dos tipos de acolchados orgánicos generados como subproductos de actividades silvícolas y agrícolas en el entorno más inmediato al área de estudio: (i) bioresiduo tipo acolchado de restos de paja y; (ii) bioresiduo tipo acolchados de astillas de pino carrasco (Pinus halepensis Mill.). Nuestros resultados describen un aumento de la macro-agregación y las tasas de infiltración del suelo, en los primeros en los 24 primero meses, tras la adición de los dos tipos de bioresiduos. Ello ha permitido un mejor aprovechamiento del agua disponible en el perfil del suelo, generando aumento en las tasas de supervivencia. Desde un punto de vista de gestión forestal, tras este estudio, se puede sugerir el uso de bioresiduos en los procesos de restauración de cubierta en áreas forestales mediterráneas.
Nowadays, the transition to a Circular Economy, in which wastes can be reduced, responds to a real and tangible need. Base on this, the management of organic residues acquires special prominence. This is because of the huge amount of wastes pr oduced and the environmental implications of their mismanagement. Based on this premise, the objective of this study is to evaluate the effects of certain types of organic residues as restoration techniques in a degraded Mediterranean area. Two types of or ganic wastes are selected: (i) straw mulch; and (ii) mulch with chipped branch of Pinushalepensis Mill . The wastes have been generated as secondary products during forestry and agricultural activities in the surrounding area. Independently of the treatment applied, our results show an increase in macro - aggregate stability and in the infiltration rates. This implies more available water for plants and, thus, the increment in the rates of survival plants. Consequently, the use of bio - wastes can be an effectiv e management technique to restore Mediterranean degraded areas.
City’s periphery, between urban segregation and extensive agriculture. Case Ituzaingó anexo, Córdoba, Argentina
Authors: Vanoli Fernando 
Published: July 2019

El barrio Ituzaingó Anexo está ubicado en la periferia sureste de la ciudad de Córdoba. Hace dieciséis años, la lucha de un grupo de madres visibilizó el conflicto ambiental que aún viven. Tal hecho, se hizo evidente al identificar enfermedades y muertes causadas por los efectos ambientales de los agrotóxicos en la producción de soja transgénica. En este trabajo, nos preguntamos de qué manera quienes deciden sobre la ciudad también son responsables de los daños ambientales producidos en este sector de la sociedad, a partir de comprender la relación del barrio con la configuración de la ciudad. Para esto, analizamos el surgimiento de Ituzaingó Anexo como barrio obrero en la expansión industrial de la ciudad y posteriormente el inicio del modelo productivo de agricultura extensiva. Haciendo énfasis en la incompatibilidad de usos habilitados por la zonificación en la planificación de la ciudad, y los efectos de segregación urbana y ambiental.
The Ituzaingó Anexo neighborhood is located on the Córdoba’s city southeast periphery. Sixteen years ago, the struggle of a mother’s group made visible the environmental conflict that they still live through. This fact became evident when they identified diseases and deaths caused by the environmental effects of agrotoxics in the production of transgenic soybeans. In this work, we wonder how those who decide about the city are also responsible for the environmental damage produced in this sector of society, understanding the relationship of the neighborhood with the configuration of the city. In this way, we analyze the creation of Ituzaingó Anexo as a working class neighborhood in the industrial expansion of the city and later the beginning of the productive model of expansive agriculture. Emphasizing the incompa tibility of uses enabled by zoning in the planning of the city, and the effects of urban and environmental segregation.
Correspondence on “Core Electron Topologies in Chemical Compounds: Case Study of Carbon versus Silicon”
Authors: von Szentpály László , Schwarz W. H. Eugen , Stoll Hermann , Werner Hans‐Joachim 
Published: July 2019

AbstractThe conclusions of a recent Communication of Yoshida, Raebiger, Shudo, and Ohno published in this journal, that varying core orbital topologies with minuscule negative tails upon bond formation determine the different chemistries of carbon and silicon and affect ionization energies, excitation energies and bond properties of molecules, are now shown to be based on computational artifacts and oversimplified models. The all‐electron wave function uniquely determines the observables, while its representation by one‐electron orbital products depends on the details of the chosen approximation and therefore need to be considered with great care.
Control of Aromaticity and cis‐/trans‐Isomeric Structure of Non‐Planar Hexaphyrin(2.1.2.1.2.1) and Metal Complexes
Authors: Xue Songlin , Kuzuhara Daiki , Aratani Naoki , Yamada Hiroko 
Published: July 2019

AbstractVinylene‐bridged hexaphyrin(2.1.2.1.2.1) was synthesized from dipyrrolyl diphenylethenes by acid‐catalyzed condensation reactions. Freebase hexaphyrin(2.1.2.1.2.1) forms a distorted structure with non‐aromatic characteristics. The aromaticity and molecular configuration of non‐planar hexaphyrin(2.1.2.1.2.1) can be controlled by insertion of metal ions. Freebase and zinc complexes show a distorted structure without macrocyclic aromaticity, whereas copper complexes show a figure‐of‐eight structure with macrocyclic aromaticity. It is the first example of aromaticity conversion of a distorted expanded porphyrin involving vinylene bridges.
Toward process‐based conservation prioritizations for freshwater ecosystems
Authors: Linke Simon , Hermoso Virgilio , Januchowski‐Hartley Stephanie 
Published: July 2019

AbstractOver the last two decades, systematic conservation planning has been increasingly applied in terrestrial and marine systems. The approach has traditionally been lagging in freshwater environments, partly because considering unique ecological processes, such as connectivity and propagation of threats along river networks, is a key factor for conservation success in freshwater landscapes. This review highlights advances in freshwater planning in the last decade, but also discusses areas in need of increased efforts.Including riverine connectivity and disturbances are largely resolved topics. Both processes have been included in major conservation planning software packages and applied globally. Theoretical advances to connectivity in wetlands and groundwater systems have started to appear, but no encompassing framework has emerged. Spatial solutions to conservation planning in lakes do not yet exist.Some headway has been made when dealing with functional connectivity and genetic processes. For the latter, approaches have been developed to deal with cryptic biodiversity and to investigate the adequacy of conservation plans to include genetic diversity. Functional connectivity has been included in conservation plans in ephemeral waterscapes, and initial steps have been made to include migratory species in conservation prioritizations.Conservation planning in socio‐ecological landscapes is catching up with biophysical prioritizations. Multiple protection tiers have been realized in river conservation planning frameworks, and freshwater scientists are leading the charge in both multi‐objective planning and in including direct functional responses. We conclude that tight integration between ecological sciences and optimization approaches is needed to further process‐based conservation planning.
Tunable modulation of antibody‐antigen interaction by protease cleavage of protein M
Authors: Kim Heejae , Gaynor Andrew , Chen Wilfred 
Published: July 2019

AbstractWhile immunoglobulins find ubiquitous use in biotechnology as static binders, recent developments have created proantibodies that enable orthogonal switch‐like behavior to antibody function. Previously, peptides with low binding affinity have been genetically fused to antibodies, to proteolytically control binding function by blocking the antigen‐binding site. However, development of these artificial blockers requires panning for peptide sequences that reversibly affect antigen affinity for each antibody. Instead, a more general strategy to achieve dynamic control over antibody affinity may be feasible using protein M (ProtM) from Mycoplasma genitalium, a newly identified polyspecific immunity evasion protein that is capable of blocking antigen binding for a wide range of antibodies. Using C‐terminus truncation to identify ProtM variants that are still capable of binding to antibodies without the ability to block antigens, we developed a novel and universal biological switch for antibodies. Using a site‐specifically placed thrombin cut site, antibody affinity can be modulated by cleavage of the two distinct antibody‐binding and antigen‐blocking domains of ProtM. Because of the high affinity of ProtM toward a large variety of IgG subtypes, this strategy may be used as a universal approach to create proantibodies that are conditionally activated by disease‐specific proteases such as matrix metalloproteinases.
Application of green analytical chemistry to a green chemistry process: Magnetic resonance and Raman spectroscopic process monitoring of continuous ethanolic fermentation
Authors: Legner Robin , Wirtz Alexander , Koza Tim , Tetzlaff Till , Nickisch‐Hartfiel Anna , Jaeger Martin 
Published: July 2019

AbstractCompact 1H NMR and Raman spectrometers were used for real‐time process monitoring of alcoholic fermentation in a continuous flow reactor. Yeast cells catalyzing the sucrose conversion were immobilized in alginate beads floating in the reactor. The spectrometers proved to be robust and could be easily attached to the reaction apparatus. As environmentally friendly analysis methods, 1H NMR and Raman spectroscopy were selected to match the resource‐ and energy‐saving process. Analyses took only a few seconds to minutes compared to chromatographic procedures and were, therefore, suitable for real‐time control realized as a feedback loop. Both compact spectrometers were successfully implemented online. Raman spectroscopy allowed for faster spectral acquisition and higher quantitative precision, NMR yielded more resolved signals thus higher specificity. By using the software Matlab for automated data loading and processing, relevant parameters such as the ethanol, glycerol, and sugar content could be easily obtained. The subsequent multivariate data analysis using partial linear least‐squares regression type 2 enabled the quantitative monitoring of all reactants within a single model in real time.
Biotransformation of Huperzine B by a Fungal Endophyte of Huperzia serrata
Authors: Zhan Zha‐Jun , Tian Ting , Xu Yi‐Lian , Yu Hang‐Fei , Zhang Cai‐Xue , Zhang Zhi‐Dong , Tang Qi‐Yong , Shan Wei‐Guang , Ying You‐Min 
Published: July 2019

AbstractThe biotransformation of huperzine B (hupB), one of the characteristic bioactive constituents of the medicinal plant Huperzia serrata, by a fungal endophyte of the host plant was studied. One new compound, 8α,15α‐epoxyhuperzine B (1), along with two known oxygenated hupB analogs, 16‐hydroxyhuperzine B (2) and carinatumin B (3), was isolated and identified. The structures of all the isolates were deduced by spectroscopic methods including NMR, MS, IR, and UV spectra. The known compounds 2 and 3 were obtained from a microbial source for the first time. To the best of our knowledge, it is the first report on the microbial transformation of hupB and would facilitate further structural modification of hupB by chemo‐enzymatic method. In the LPS‐induced neuro‐inflammation injury assay, 8α,15α‐epoxyhuperzine B (1) exhibited moderate neuroprotective activity by increasing the viability of U251 cell lines with an EC50 of 40.1 nm.
MAPK‐mediated upregulation of fibrinogen‐like protein 2 promotes proliferation, migration, and invasion of colorectal cancer cells
Authors: Liu Xiaochuan , Chu Yunxiang , Wang Dongsheng , Weng Yan , Jia Zhiwei 
Published: July 2019

AbstractFibrinogen‐like protein 2 (FGL2) has been reported to play a key role in the development of human cancers. However, it is still unmasked whether FGL2 plays a potential role in colorectal carcinogenesis. In this study, the messenger RNA and protein expression levels were measured by quantitative real‐time polymerase chain reaction and western blot. Cell counting kit‐8 assay, transwell migration, and invasion assay were carried out to evaluate the proliferation, migration, and invasion of LOVO and SW620 cells. FGL2 was upregulated in colorectal cancer (CRC) tissues, as well as cell lines. Mitogen‐activated protein kinase (MAPK) signaling was activated in CRC tissues and cell lines. FGL2 was confirmed to be downregulated by MAPK signaling inhibitor U0126. Further, we determined that knockdown of FGL2 caused a reduction of proliferation, migration, and invasion in LOVO and SW620 cells. Consistently, treatment of LOVO and SW620 cells with U0126 led to a decrease in cell proliferation, migration, and invasion. However, these changes initiated by U0126 were abolished by FGL2 overexpression. To conclude, MAPK‐mediated upregulation of FGL2 promotes the proliferation, migration, and invasion of CRC cells.