bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in Structural Biology of ACE and Development of Domain Selective ACE-inhibitors
Authors: Polakovičová Mája , Jampílek Josef 
Published: May 2019

Background:The Angiotensin-I converting enzyme (ACE) is one of the most important components of the renin-angiotensin-aldosterone system controlling blood pressure and renal functions. Inhibitors of ACE are first line therapeutics used in the treatment of hypertension and related cardiovascular diseases. Somatic ACE consists of two homologous catalytic domains, the C- and N-domains. Recent findings have shown that although both domains are highly homologous in structure, they may have different physiological functions. The C-domain is primarily involved in the control of blood pressure, in contrast to the N-domain that is engaged in the regulation of hematopoietic stem cell proliferation. The currently available ACE inhibitors have some adverse effects that can be attributed to the non-selective inhibition of both domains. In addition, specific Ndomain inhibitors have emerged as potential antifibrotic drugs. Therefore, ACE is still an important drug target for the development of novel domain-selective drugs not only for the cardiovascular system but also for other systems.Objective:Detailed structural information about interactions in the protein-ligand complex is crucial for rational drug design. This review highlights the structural information available from crystallographic data which is essential for the development of domain selective inhibitors of ACE.Methods:Over eighty crystal complexes of ACE are placed into the Protein Database. An overview of X-ray ACE complexes with various inhibitors in C- and N-domains and an analysis of their binding mode have given mechanistic explanation of the structural determinants of selective ligand binding. In addition, ACE domain selective inhibitors with dual modes of action in complexes with ACE are also discussed.Conclusion:Selectivity of ACE inhibitors for the N- and C-domain is controlled by subtle differences in the amino-acids forming the active site. Reported studies of crystal complexes of inhibitors in the C- and N-domains revealed that most selective inhibitors interact with non-conserved amino-acids between domains and have distinct interactions with the residues in the S2 and S2’ subsites of the ACE catalytic site. Moreover, unusual binding of the second molecule of inhibitors in the binding cavity opens new possibilities of exploiting more distant regions of the catalytic center in structure-based design of novel drugs.
Low Leakage Optimization Techniques for Multi-threshold CMOS Circuits
Authors: Rastogi Rumi , Pandey Sujata , Gupta Mridula 
Published: May 2019

Background:With the reducing size of the devices, the leakage power has also increased exponentially in the nano-scale CMOS devices. Several techniques have been devised so far to minimize the leakage power, among which, MTCMOS (power-gating) is the preferred one as it effectively minimizes the leakage power without any complexity in the circuit. However, the power-gating technique suffers from problems like transition noise and delay. In this paper, we proposed a new simple yet effective technique to minimize leakage power in MTCMOS circuits.Objective:The objective of the paper was to propose a new technique which effectively minimizes leakage power in nanoscale power-gated circuits with minimal delay, noise and area requirement so that it can well be implemented in high-speed low-power digital integrated circuits.Methods:A new power-gating structure has been proposed in this paper. The new proposed technique includes three parallel NMOS transistors with variable widths which are functional during the active mode to reduce the on-time delay. A PMOS footer with gate-bias is also connected in parallel with the NMOS footer transistors. The proposed technique has been verified through simulation in 45nm MTCMOS technology to implement a 32 bit adder circuit.Results:The proposed technique offers significant reduction in leakage power, reactivation noise and reactivation energy. The technique reduced the leakage power effectively at room temperature as well as higher temperatures. The reactivation noise produced by the proposed technique minimized by 98.7%, 64.8%, 62.07% and 24.47% as compared to the parallel transistor, variable-width, charge-recycling and the modified-charge recycling techniques respectively at room temperature.The reactivation energy of the proposed technique also minimized by 77.by 77.67%, 55.8%, 45.1%, and 18.32% with respect to the parallel transistor, variable-width, CR and Modified-CR techniques, respectively.Conclusion:The proposed technique offers significant reduction in leakage power, reactivation noise and reactivation energy. The technique reduces the leakage power effectively at room temperature as well as at higher temperatures. Since the delay and area overhead of the proposed structure is minimal, hence it can be easily implemented in high-speed low-power digital circuits.
Solid State Kinetics, Spectroscopic, Thermal Degradation and Fungicidal Studies of Biodegradable Copper Surfactants Derived from Lauric Acid
Authors: Jain Shilpa , Sharma Rashmi , Sharma Arun K. 
Published: May 2019

Introduction:
The synthesis of copper soap (laurate), and its complex with 2-amino 6-
methylbenzothiazole and their elemental and spectral analysis have been done for comparative studies
using IR, NMR, Mass and ESR spectra.

Methods:
The fungicidal activities, with reference to Alternaria alternata and Aspergillus niger at
different concentrations by P.D.A. technique were also studied.

Results and Conclusion:
The present research work comprises detailed thermal analysis using
TGA technique to determine their kinetic and thermodynamic parameters by applying various
equations like Freeman Carroll, Coats-Redfern equation, Horowitz-Metzger equation, Broido
equation, Piloyan–Novikova equation.
¿Ni con el pétalo de una rosa? Discriminación hacia las mujeres en la vida diaria de tres facultades
Authors: Mingo Araceli 
Published: May 2019

Con el propósito de indagar las formas particulares que adoptan las relaciones de género dentro de la comunidad estudiantil de la Universidad Nacional Autónoma de México, se realizaron grupos focales en tres facultades de esta universidad. Los relatos que se presentan en este artículo permiten apreciar la perseverancia de añejos prejuicios que se traducen en actitudes y comportamientos discriminatorios con los que la población femenina tiene que lidiar, en el día a día, por el sólo hecho de ser mujeres.
Para enseñar ética profesional no basta con una asignatura: los estudiantes de Psicología reportan incidentes críticos en aulas y escenarios reales
Authors: Díaz Barriga Frida , Pérez-Rendón María Maclovia , Lara Gutiérrez Yazmín 
Published: May 2019

El asunto de la formación ética profesional ha tendido a resolverse mediante la introducción de al menos una asignatura en el plan de estudios de las universidades. Sin embargo, el análisis de los incidentes críticos que relatan los estudiantes respecto a cómo se transgrede en la realidad el código ético, conduce a cuestionar que esto es necesario pero no es suficiente. En este artículo se expone el análisis de incidentes críticos (IC) de ética profesional narrados por 57 estudiantes de licenciatura en Psicología pertenecientes a una universidad pública, quienes cursaban en sexto semestre la asignatura de Ética Profesional. En dichos incidentes aparece que los principios éticos de la profesión psicológica que se transgreden con más frecuencia se vinculan con la competencia y honestidad en el ejercicio de los profesionales, así como con la calidad de la enseñanza, investigación o supervisión en escenarios reales por parte de los profesores universitarios. Más de la mitad de los incidentes críticos narrados ocurren en escenarios clínicos o del sector salud, seguidos de los escenarios educacionales en instituciones públicas, en la propia universidad y en contextos comunitarios. El papel asumido por los estudiantes en su propio relato es de testigo, receptor, transgresor o escucha, en ese orden. Los resultados se discuten en términos del currículo formal, oculto y nulo, del ethos profesional y de la propia institución educativa, así como de la necesidad de replantear la formación ética de los psicólogos en la universidad.
Pengaruh Perbedaan Spesies Luwak Terhadap Kadar Kofein Dari Kopi Luwak Jenis Robusta
Authors: Yulia Rahma , Zamrud Adnan Adek , Prima Putra Deddi 
Published: May 2019

<p><span>The influence of different species of civet on caffeine content of Robusta civet coffee ( Coffea Robusta) had been done. The Civet species used are </span><em>Paradoxurus Hermophroditus </em><span>(Pandan civet) and </span><em>Arctictis Binturong</em><span> ( Bulan civet). The Coffee used is Robusta varieties ( Coffea Robusta). Caffeine’s level of robusta civet coffee has been given to two species of civet and after that they are analyzed using TLC Scanner Method quantitatively. The process of robusta civet coffee extraction was done by using Dichloromethane solvent and sonicated for 15 minutes on themperature 40 º C, then the filtrate obtained was filtered with whatmant filter paper, then concentrated by using rotary evaporator. The quantitative analysis measured from the caffeine was measured using Thin Layer Chromatograpy ( TLC ) then Scanned by Densitometry ( TLC Scanner ) to obtain the content of caffeine from the civet coffee. Robusta coffee beans given to the civet Bulan (</span><em>Arctictis Binturong)</em><span> species have 1,91 % caffeine content where the caffeine content is higher when compared to robusta coffee given to Pandan civet (</span><em>Paradoxurus Hermophroditus)</em><span> which has only 1,30 % caffeine. Based on the SPSS 21 anne-ment using anava Three Roads, it is known that differences in civet species affect the levels of robusta civet coffee caffeine.</span></p><p>Telah dilakukan Penelitian Pengaruh Perbedaan Spesies Luwak Terhadap Kadar Kofein dari Kopi Luwak Jenis Robusta (<em>Coffea Robusta</em>). Spesies Luwak yang digunakan adalah <em>Paradoxurus Hermophroditus</em> ( Luwak Pandan) dan <em>Arctictis Binturong</em> ( Luwak Bulan). Kopi yang dipakai adalah spesies Robusta ( <em>Coffea Robusta</em>). Kadar kofein kopi luwak robusta yang diberikan kepada dua spesies luwak tersebut kemudian dianalisis menggunakan metode TLC Scanner secara kuantitatif. Proses Ekstraksi Kopi luwak robusta dilakukan dengan menggunakan pelarut diklorometan dan disonikasi selama 15 menit kemudian filtrate yang diperoleh disaring dengan kertas saring Whatman kemudian dipekatkan dengan rotary evaporator. Analisis kuantitatif dari kofein di ukur dengan menggunakan Kromatografi Lapis Tipis ( KLT ) kemudian di Scanning dengan alat Densitometri (TLC Scanner) sehingga diperoleh kadar kofein dari kopi luwak tersebut. Biji Kopi Robusta yang diberikan pada Spesies luwak Bulan ( Arctictis Binturong ) mempunyai kadar kofein 1, 91 % dimana kadar kofein ini lebih tinggi jika dibandingkan dengan kopi robusta yang diberikan kepada luwak pandan (<em>Paradoxurus Hermophroditus)</em> yang hanya memiliki kadar kofein 1, 30 %. Berdasarkan analisis SPSS 21 menggunakan Anava tiga Jalan diketahui bahwa perbedaan spesies luwak mempengaruhi kadar kofein kopi luwak robusta.</p>
Efficacy of Direct Restorative Materials in Proximal Box Elevation on the Margin Quality and Fracture Resistance of Molars Restored With CAD/CAM Onlays
Authors: Grubbs TD , Vargas M , Kolker J , Teixeira EC 
Published: May 2019

SUMMARY

Purpose:
The purpose of this study was to investigate the effect of four direct restorative materials that can be used in the proximal box elevation (PBE) technique.

Methods and Materials:
Seventy-five molar teeth were randomly assigned to one of five groups (n=15): type II glass ionomer (GI), type II resin-modified glass ionomer (RMGI), resin-based composite (RBC), bulk-fill (BF) resin-based composite, and a control with no box elevation procedure. Specimens were prepared for a standard mesio-occlusal-distal, computer-aided design/computer-aided manufactured (CAD-CAM) resin, nanoceramic onlay with mesial cervical margins located 1 mm above the cementoenamel junction (CEJ) and distal cervical margins located 2 mm below the CEJ. PBE was used to elevate the distal margins to 1 mm above the CEJ in all groups except the control group. For the control group the onlay margin was placed directly on the prepared distal tooth structure without PBE. A Lava Ultimate CAD/CAM resin, nanoceramic onlay restorative was manufactured and bonded on all specimens with RelyX Ultimate adhesive resin cement. The quality of the tooth-PBE material and PBE material-onlay interface was evaluated with scanning electron microscopy using epoxy resin replicas before and after cyclic loading (100,000 cycles, 1.2 Hz at 65N and 37°C). In addition to margin quality, the fracture resistance of each group was measured using a universal testing machine. Fracture pattern was recorded by visual examination. The Levene test for homogeneity and the Welch analysis of variance were completed for fracture resistance and margin quality. A χ2 test was completed for break mode.

Results:
For dentin margins, a statistically significant difference was detected between the RMGI and control groups at baseline (p=0.0442). All other groups—GI, RBC, and BF—showed no difference from the control at baseline (p&gt;0.05). No statistical significance was observed among groups for post-cyclic fatigue (p=0.8735). For onlay margins, no statistical significance was observed among groups for pre-cyclic fatigue, post-cyclic fatigue, or change (p=0.9713, p=0.528, p=0.4385, respectively). No significant difference was observed for the fracture resistance among groups or for the type of break by material used (p=0.1593, p=0.77, respectively).

Conclusion:
Within the parameters of this study, after mechanical fatigue, the materials used for PBE: RMGI, RBC, and BF, did not influence results in terms of margin quality and fracture resistance. Therefore, collective findings suggest that these materials might be suitable for PBE procedures. Nevertheless, clinical caution is recommended with any PBE procedure and further testing of GI materials is needed.
The Impact of Childhood Trauma and Depressive Symptoms on Body Mass Index
Authors: Schulze Lara N. , Van der Auwera Sandra , Janowitz Deborah , Hertel Johannes , Wittfeld Katharina , Walk René , Friedrich Nele , Völzke Henry , Grabe Hans J. 
Published: May 2019

Abstract

Objectives
Obesity is associated with several somatic diseases and increased psychological burden. This study focused on two potential psychological predictors of the body mass index (BMI), childhood trauma and depressive symptoms.

Methods
We used three independent populations: two general population samples (Study of Health in Pomerania, SHIP-2, N = 1,657; SHIP-TREND-0, N = 3,278) and one patient sample (GANI_MED, N = 1,742). Childhood trauma was measured with the childhood trauma questionnaire (CTQ) and depression with the Beck Depression Inventory (BDI-II) in SHIP-2 and the Patient Health Questionnaire (PHQ-9) in SHIP-TREND-0 and GANI_MED. We investigated the impact of childhood trauma and depression on BMI. Furthermore, we used mediation analysis to assess whether depression was a significant mediator on the path from childhood trauma to adult BMI in each of the three samples.

Results
In all the three populations, depressive symptoms exhibited a significant association towards higher BMI (p < 0.05). Childhood trauma was positively associated with BMI with significant associations in SHIP-TREND-0 (p < 0.001) and GANI_MED (p = 0.005). The relationship between CTQ and BMI was significantly partially mediated (p < 0.05) by depressive symptoms in SHIP-TREND-0 (38.0%) and GANI_MED (16.4%), in SHIP-2 results pointed in the same direction. All the trauma sub-dimensions, except sexual abuse, exhibited at least one significant association towards increased BMI in one of the samples.

Conclusions
Childhood trauma and depressive symptoms may be considered as causes of obesity. These results suggest that psychological treatments against obesity should address childhood maltreatment as well as depressive symptoms in their diagnostic assessment and could facilitate psychotherapeutic treatment when necessary.
To Communicate Without Signs Through Expressive Qualities
Authors: Sinico Michele 
Published: May 2019

Summary
The present paper introduces the theoretical conceptualization of perceptual communication through expressive qualities. Initially, the difference with respect to the modality of perceptual communication mediated by signs is analyzed. Conversely, the theory of expressive qualities reflects the psychological conception of direct perception: any assumption of a cognitive stage of representation is excluded. Perceptual communication immediately expresses the specific character of the structural essence of the object. The structural essence is well studied by the perceptual paradigms of Experimental Phenomenology. Plurivocity, the case in which the same objects can share many expressive characters, is also considered.
Phylogenetic Analysis of Tetragonula Minangkabau and Other Species Using Cytochrome B Gene
Authors: Christy Buti Y. , Roesma Dahelmi Dewi I. 
Published: May 2019

Abstract

Tetragonula a genus in the Meliponini tribe (Apidae), is difficult to identify due to the many cryptic species. As technology develops, molecular taxonomic studies are used to help identify species with limited morphological characteristics. This study presents an analysis of the phylogenetic relationship between several species in the Tetragonula genus based on the sequences of the cytochrome b gene. Maximum parsimony, neighbor joining, maximum likelihood and minimum evolution methods were used to construct phylogenetic trees. The sequence divergence between T. minangkabau collected from Limau Manis and Ulu Gadut is 0.8%, while between T. minangkabau with T. minangkabau forma darek 5.5%. The low sequence divergence indicated that T. minangkabau and T. minangkabau forma darek have a close phylogenetic relationship. The analysis showed that Tetragonula (T. minangkabau, T. minangkabau forma darek, T. laeviceps, T. drescheri and T. fuscobalteata) is monophyletic. A sequence divergence of 5.5% supports the separation of Tetragonula minangkabau and T. minangkabau forma darek.
Reconfigurable control of flexible joint robot with actuator fault and uncertainty
Authors: Elghoul Aymen , Tellili Adel , Abdelkrim Mohamed Naceur 
Published: May 2019

Abstract
This paper presents the fault tolerant control (FTC) of a flexible joint robot using singular perturbation method in order to compensate for the lost performance due to the occurrence of actuator fault and the uncertainty. This FTC is based on Lyapunov redesign principle. The singular perturbation method is used to reduce the dynamic model of the flexible joint robot in a fast and slow subsystem. The time scale reduction of the flexible joint model is carried out when their joint stiffness is large enough and the singular perturbation parameter is set to zero. The fault-tolerant control structure in this paper is based on two parts. The first term described the composite control for the system without defect and without uncertainty which represents the sum between slow and fast controllers. While the second term of the fault tolerant command describes additive control designed to compensate for the fault effect of the actuator on the uncertain system. The additive approach is based on the Lyapunov theorem, which guarantees asymptotic stability despite the presence of actuator defects and the parametric uncertainty. The theoretical results are applied on a robot manipulator with a single flexible joint.
Growth, solvent effect, optical and electrical properties of sodium 4-hydroxybenzenesulfonate dihydrate
Authors: Zahid Md. I. , Malarkodi A. , Meera Sreenarayanan , Meera K. , Joseph Wilson K.S. , Mohan Kumar R. 
Published: May 2019

Abstract
Single crystal of sodium 4-hydroxybenzenesulfonate dihydrate (Na-4-HBS) was grown from an aqueous solution by slow evaporation method. Powder X-ray diffraction study was carried out to identify the lattice parameters of the crystal. FT-IR spectral analysis confirmed the existence of various functional groups in the compound. The optical transmittance, cut-off wavelength and band gap energy were estimated from the UV-Vis studies. Photoluminescence studies revealed the transition mechanism by optical excitation. The variation of dielectric properties and AC conductivity of the grown crystal with frequency was studied at different temperatures. Measurements of mechanical properties of Na-4-HBS were carried out to find the hardness of the material. The laser induced surface damage threshold and relative second harmonic generation nonlinear optical properties of the grown crystal were studied using Q-switched Nd:YAG laser.
“Let None Desert the Church on My Account”Some Inconsistencies Regarding the Chrysostomic Vision on the Unity of the Church
Authors: Boicu Dragoş 
Published: May 2019

Abstract
By comparing St. John Chrysostom’s statements on Church unity after his dismissal, one can notice serious inconsistencies between the texts written by John himself and the statements attributed to him by Palladius of Helenopolis, who attempted to attenuate the outcome of the Johannite schism. In fact, the discrepancies are considerable and the Chrysostomic epistles addressed to the oriental bishops (85-90) imply that St. John encouraged the schism.
The “Ecumenism” of the Desert Fathers. The Relationship with the Other in Apophthegmata Patrum
Authors: Siladi Paul 
Published: May 2019

Abstract
Ecumenism is a 20th century concept that cannot be directly transposed in the everyday reality of the Desert Fathers, but the authority of the desert ascetics is still crucial to the monastic milieu of the Orthodox Church as well as other denominations. For this very reason, the present paper intends to investigate the stories recorded in the alphabetical collection of the Egyptian Paterikon in order to understand to what extent they may actually offer a guide to the complex relations with the Other. How do these stories illustrate denominational or even religious alterity? What types of rapports can one identify therein? Rejection? Separation? Acceptance of the other’s difference? These are all legitimate questions and their significance is amplified in the context of our times – a period in which we see an increase in fundamentalist movements and tendencies, including in the Orthodox community.