bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supporting Women-Led Businesses: Narrative Review of Recent Causal Evidence
Authors: Ubfal Diego 
Published: December 2024

Abstract
Innovative women entrepreneurs can be agents of change and offer novel solutions to global challenges. However, they face multiple barriers to growing their businesses. I review the literature on strategies to support women entrepreneurs in improving their business outcomes. I focus on interventions designed to address four areas of constraints that influence their decisions and can impact their business performance: gaps in human capital, access to finance, access to technology and markets, and contextual factors such as legal and regulatory constraints, social norms, access to care, and gender-based violence. I conclude that evidence of modest average treatment effects and heterogeneity in treatment effects across various interventions suggests the need for more precise targeting. The multiple constraints faced by women entrepreneurs necessitates testing different packages of interventions. Moreover, the successful implementation and adoption of proposed solutions require consideration of the contextual constraints that differentially affect women-led businesses. While I highlight several interventions that show promise in supporting women entrepreneurs, significant gaps remain in the evidence concerning the most effective strategies.
Evolutionary, taxonomical, and ecological traits of the Late Neogene armadillo Macrochorobates Scillato-Yané (Xenarthra: Cingulata)
Authors: Barasoain Daniel , Tomassini Rodrigo L , Quiñones Sofía I , González-Ruiz Laureano R , Bonini Ricardo A , Zurita Alfredo E 
Published: December 2024

Abstract
Within armadillos, two clades are currently recognized: Chlamyphoridae and Dasypodidae. Major evolutionary processes of Chlamyphoridae are linked to the main environmental and climatic events that occurred in South America in the Cenozoic. More precisely, the Euphractinae reached a high diversity concomitant with the cooling period of the Late Miocene–Pliocene. One of the largest euphractines is Macrochorobates, which includes the species M. scalabrinii and M. chapalmalensis, differentiated by minor details on the osteoderms of the dorsal carapace. This genus had a wide distribution, with records in Late Miocene–Pliocene deposits of different regions of Argentina. Here we describe and compare new specimens of M. scalabrinii, which represent the most complete material known so far. Our comparative analysis strongly suggests that M. chapalmalensis represents a junior synonym of M. scalabrinii. This way, the biochron of M. scalabrinii would range from the Late Miocene to the Late Pliocene. Additionally, anatomical comparisons and cladistic analysis show that Macrochorobates and Macroeuphractus (another Late Neogene large euphractine) share some cranial characters, not observable in other armadillos; therefore, we propose that Macrochorobates scalabrinii could have had intermediate carnivorous diets between more generalist taxa such as Euphractus and the specialized carnivory proposed for Macroeuphractus.
The long-eared freshwater planarians of Madagascar form a separate phylogenetic clade within the genus Dugesia (Platyhelminthes: Tricladida), with the description of two new species
Authors: Stocchino Giacinta Angela , Sluys Ronald , Solà Eduard , Riutort Marta , Manconi Renata 
Published: December 2024

Abstract
Madagascar and the Comoros Archipelago are inhabited by freshwater planarians of the genus Dugesia characterized by a unique morphotype with long and pointed auricles, which were traditionally ascribed to only one species, Dugesia milloti. Collections of new specimens of these long-eared freshwater triclads enabled us to examine these worms in more detail than previously had been possible and, thus, we were able to study the animals from an integrative perspective, including morphological, karyological, and molecular data. In addition, we re-examined D. milloti specimens that were available from natural history collections. In contrast to previous notions, we found that at least seven species of long-eared planarians inhabit the Malagasy inland waters, two of which are here newly described, viz., Dugesia crassimentula Sluys & Stocchino, sp. nov., and Dugesia insolita Stocchino & Sluys, sp. nov. Molecularly, the long-eared planarians form a separate phylogenetic clade that is not closely related to the other distinct morphotypes of Malagasy congeners. Furthermore, our karyological analyses revealed a new haploid (n = 5) chromosome number for the genus Dugesia, being the lowest chromosome number presently known for this genus. In addition, a previously unknown autotomy-like behaviour in freshwater triclads is reported here for the first time.
Perioperative Hypotension in Chronic Kidney Disease Patients with Dialysis Undergoing Noncardiac Surgery: A Retrospective Cohort Study
Authors: Tok Cekmecelioglu Busra , Tire Yasin , Sertcakacilar Gokhan , Ekrami Elyad , Pu Xuan , Kopac Orkun , Chu Jeffrey , Roshanov Pavel S. , Argalious Maged , Ruetzler Kurt , Turan Alparslan 
Published: December 2024

Background:
Patients with chronic kidney disease who require maintenance dialysis suffer excess morbidity and mortality for reasons that are not clearly elucidated. There are few targets for intervention to improve their outcomes. The authors hypothesized that perioperative hypotension is more common in patients receiving dialysis.

Methodology:
A retrospective cohort study was conducted of adult patients who had inpatient noncardiac surgery lasting greater than 2 h with general anesthesia between January 2012 and December 2021 at the Cleveland Clinic (Cleveland, Ohio). Using International Classification of Diseases codes and dialysis documentation in the electronic medical record, was derived age, American Society of Anesthesiologists (Schaumburg, Illinois) Physical Status, surgery type, and propensity score (predicting dialysis dependence) matched groups of patients (1) with dialysis-dependent chronic kidney disease, (2) with nondialysis chronic kidney disease, and (3) without kidney disease. The primary outcomes were total area under the curve of mean arterial pressure (MAP) less than 65 mmHg during the surgery and postoperative MAP less than 70 mmHg during 48 h after surgery.

Results:
Three 1:1:1 matched groups of 1,886 patients (total, 5,658 patients) from an overall cohort of 123,761 were derived. Cases with dialysis-dependent kidney disease had a greater intraoperative area under the curve of MAP less than 65 mmHg (difference in medians, 18.4 mmHg-min 98.75% CI, 11.3 to 25.6; P < 0.001) when compared to patients who had nondialysis kidney disease and when compared to patients without kidney disease (difference in medians, 15.5 mmHg-min; 98.75% CI, 6.6 to 24.4; P < 0.001). Patients receiving preoperative dialysis were also more likely to have postoperative MAP less than 70 mmHg compared to patients with nondialysis kidney disease (rate ratio, 1.52; 98.75% CI, 1.48 to 1.57; P < 0.0001) and compared to patients without kidney disease (rate ratio, 1.43; 98.75% CI, 1.38 to 1.47; P < 0.0001).

Conclusions:
Perioperative hypotension is more severe and common among patients who undergo chronic maintenance dialysis compared to similar patients without dialysis dependence. The management of hemodynamics in this population comes with unique considerations that warrant further systematic evaluation.
ResNet-Vision Transformer based MRI-endoscopy fusion model for predicting treatment response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: A multicenter study
Authors: Zhang Junhao , Liu Ruiqing , Hao Di , Tian Guangye , Zhang Shiwei , Zhang Sen , Zang Yitong , Pang Kai , Hu Xuhua , Ren Keyu , Cui Mingjuan , Liu Shuhao , Wu Jinhui , Wang Quan , Feng Bo , Tong Weidong , Yang Yingchi , Wang Guiying , Lu Yun 
Published: December 2024

Abstract

Background:
Neoadjuvant chemoradiotherapy followed by radical surgery has been a common practice for patients with locally advanced rectal cancer, but the response rate varies among patients. This study aimed to develop a ResNet-Vision Transformer based magnetic resonance imaging (MRI)-endoscopy fusion model to precisely predict treatment response and provide personalized treatment.

Methods:
In this multicenter study, 366 eligible patients who had undergone neoadjuvant chemoradiotherapy followed by radical surgery at eight Chinese tertiary hospitals between January 2017 and June 2024 were recruited, with 2928 pretreatment colonic endoscopic images and 366 pelvic MRI images. An MRI-endoscopy fusion model was constructed based on the ResNet backbone and Transformer network using pretreatment MRI and endoscopic images. Treatment response was defined as good response or non-good response based on the tumor regression grade. The Delong test and the Hanley–McNeil test were utilized to compare prediction performance among different models and different subgroups, respectively. The predictive performance of the MRI-endoscopy fusion model was comprehensively validated in the test sets and was further compared to that of the single-modal MRI model and single-modal endoscopy model.

Results:
The MRI-endoscopy fusion model demonstrated favorable prediction performance. In the internal validation set, the area under the curve (AUC) and accuracy were 0.852 (95% confidence interval [CI]: 0.744–0.940) and 0.737 (95% CI: 0.712–0.844), respectively. Moreover, the AUC and accuracy reached 0.769 (95% CI: 0.678–0.861) and 0.729 (95% CI: 0.628–0.821), respectively, in the external test set. In addition, the MRI-endoscopy fusion model outperformed the single-modal MRI model (AUC: 0.692 [95% CI: 0.609–0.783], accuracy: 0.659 [95% CI: 0.565–0.775]) and the single-modal endoscopy model (AUC: 0.720 [95% CI: 0.617–0.823], accuracy: 0.713 [95% CI: 0.612–0.809]) in the external test set.

Conclusion:
The MRI-endoscopy fusion model based on ResNet-Vision Transformer achieved favorable performance in predicting treatment response to neoadjuvant chemoradiotherapy and holds tremendous potential for enabling personalized treatment regimens for locally advanced rectal cancer patients.
Clinical practice guideline for the management of hypertension in China
Authors:   Chinese Society of Cardiology, Chinese Medical Association; Hypertension Committee of Cross-Straits Medicine Exchange Association; Cardiovascular Disease Prevention and Rehabilitation Committee, Chinese Association of Rehabilitation Medicine
Published: December 2024

Abstract

In China, hypertension is the most common chronic non-communicable disease and the most significant risk factor for cardiovascular mortality among urban and rural residents. To standardize the clinical diagnosis and treatment of hypertension and to improve the prevention and control level of hypertension in China, Chinese Society of Cardiology, Chinese Medical Association; Hypertension Committee of Cross-Straits Medicine Exchange Association; Cardiovascular Disease Prevention and Rehabilitation Committee, Chinese Association of Rehabilitation Medicine, jointly collaborated to formulate the Clinical Practice Guideline for Hypertension Management in China. The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to rate the quality of evidence and strength of recommendations, and the reporting items for practice guidelines in healthcare (RIGHT) were followed to establish the guideline. Detailed evidence-based recommendations for the diagnosis, evaluation, and treatment of 44 clinical questions in the field of hypertension, including essential and secondary hypertension, have been provided to guide clinical practice.

Registration:
International Practice Guidelines Registry Platform, http://www.guidelines-registry.cn/, No. IPGRP-2021CN346.
Dose Estimation for Indoor Radon, Occupational Radiation, and Electromagnetic Field Exposure in a Nuclear Medicine Department in Turkiye
Authors: Sahmaran T. , Nur S. , Atılgan H.I. , Peker H. 
Published: December 2024

Abstract
In this study, the occupational radiation dose, radon gas, and non-ionizing radiation doses originating from electromagnetic fields (EMF) to which radiation workers are exposed were monitored and evaluated for 1 y. Using electronic personnel dosimeters (EPD), average daily radiation doses based on the number of patients and annual average effective dose results of radiation workers were obtained over a period of 1 y. Also, the annual effective dose and risk values were calculated for 8 h and 24 h by taking radon gas measurements at 2-mo intervals in the nuclear medicine department. Finally, electric field measurements were made one day a week in the selected areas. All the results obtained were compared with national and international dose limits. The results obtained as a result of EPD, radon gas, and EMF measurements made in the nuclear medicine department were found to be far below the international and national legal dose limits.
Comparing the Waste and Environmental Impact of Blepharoplasty at an Office-based Operating Room Versus an Ambulatory Surgery Center in the United States
Authors: Hu Daniel J. , Rizzuto Philip R. 
Published: December 2024

Purpose:
The aim of the study was to evaluate the environmental impact of a blepharoplasty as performed by a single surgeon at an office-based operating room (OR) versus at an ambulatory surgery center.

Methods:
We employed life cycle analyses on routine, uncomplicated bilateral upper lid blepharoplasties as performed by a single surgeon. Life cycle phases of production, use, and end-of-life treatment were included. Study boundaries encompassed all waste products exiting the OR in addition to utility energy and water use. We conducted waste audits to collect data on surgical waste by item, material, and weight. Building energy and water use were approximated using data obtained from utility companies. Environmental impact is reported as global warming potential (GW100a; kg carbon dioxide equivalents).

Results:
The office-based OR generated 784 g of physical waste per blepharoplasty as compared to 1323 g at the ambulatory surgery center. The life cycle analyses found that a blepharoplasty contributed a total of 6.42 kg carbon dioxide equivalents at the office-based OR and 7.78 at the ambulatory surgery center. The production phase contributed the majority of these carbon dioxide equivalents. Plastic supplies contributed the most waste by weight and emissions associated with production. Nonwoven polypropylene contributed the largest waste and emissions by material.

Conclusion:
The ambulatory surgery center produces more waste and carbon dioxide equivalents per blepharoplasty than the office-based OR. Use of supplies including drapes and gowns made of nonwoven polypropylene can be reduced to increase the environmental sustainability of blepharoplasty.
Development of Clinical Judgment in Prelicensure Nursing Students Through Simulation
Authors: Bussard Michelle E. , Jacobs Lisa A. , Mahoney Sarah A. , Davis Lacey L. , Oberhaus Annette M. , Lavoie Patrick 
Published: December 2024

Background:
There is a lack of longitudinal studies measuring student progression in clinical judgment. Previous studies measured gains in clinical judgment after 1 intervention or over 1 semester.

Purpose:
This study evaluated the development and progression of clinical judgment in simulation throughout a prelicensure bachelor of science in nursing (BSN) program using the Lasater Clinical Judgment Rubric (LCJR).

Methods:
This retrospective longitudinal study evaluated clinical judgment using the LCJR over 4 semesters, with a sample of 53 prelicensure nursing students. Each student had 18 simulation scores recorded during the study. A linear mixed model was employed to compare LCJR average scores from the beginning to the end of the program and across each semester.

Results:
Eighteen simulations were reviewed among 4 nursing courses. LCJR scores increased progressively from the first to the fourth semester.

Conclusions:
Students showed progression of clinical judgment throughout a BSN curriculum using the LCJR as an assessment tool.
Association of chronic pain with incidence and progression of cardiometabolic multimorbidity in middle-aged and older populations: a multicohort study
Authors: You Yating , Zhou Yaguan , Chen Hui , Kancheva Angelina Kirilova , Carrillo-Larco Rodrigo Martin , Yuan Changzheng , Xu Xiaolin 
Published: December 2024

Abstract

Introduction:
Chronic pain is associated with single cardiometabolic diseases (CMDs). Less is known about the association of chronic pain with the co-occurrence of multiple CMDs, known as cardiometabolic multimorbidity (CMM).

Objectives:
This study aims to examine the association between chronic pain and incidence of CMM and if it existed, to what extent chronic pain relates to the progression of specific CMD-related multimorbidity (MM).

Methods:
We pooled individual-level data of 59,134 participants from 4 cohort studies across 18 countries between 2010 and 2020. Participants aged 45 years or older, free of CMDs (diabetes, heart diseases, and stroke), and with self-reported chronic pain status at baseline were included. Multinomial logistic regression was performed on the association of chronic pain with incident CMM and the progression of specific CMD-related MM.

Results:
One-third (21,204) of participants reported chronic pain at baseline. After 8 to 9 years, 1344 (2.3%) developed CMM. Chronic pain was associated with the onset of each CMD (odds ratio [OR] range 1.12–1.37) and CMM combinations (OR range 1.57–2.09). It is also linked with the increased odds of more CMDs (1, 2, and 3) during the follow-up. For example, OR increased from 1.31 for individuals with one CMD, to 1.57 for those with 2 CMDs, to 2.09 for those with 3 CMDs. Chronic pain was also associated with developing all CMD-related MM (OR range 1.26–1.88). Compared with those with diabetes only, participants with chronic pain were more likely to progress to diabetes and heart diseases, as well as diabetes, heart diseases, and stroke.

Conclusion:
Chronic pain is associated with incidence and progression of CMM, whose management should be considered in primary and secondary prevention of CMM among middle-aged and older populations.
Temporal characteristics of foot rollover of amputee walking gait when using an Energy Storage and Return prosthesis
Authors: Muñoz-Larrosa Eugenia Soledad , Garcia-Añino Eloisa , Schlotthauer Gaston , Shaheen Aliah F. , Oldfield Matthew , Catalfamo-Formento Paola 
Published: December 2024

Background:
Energy Storage and Return (ESAR) prosthetic feet provide improved walking when compared with previous designs. However, it may not mimic the unimpaired smooth and progressive movement of the foot on the floor (foot rollover).

Objective:
To characterize the temporal foot rollover of participants with unilateral transtibial amputation using an ESAR prosthetic foot.

Study design:
Cross-sectional.

Methods:
Plantar pressure data were collected from 11 participants with unilateral transtibial amputation using ESAR prostheses (2 females, mean age 37 ± 10 years, activity levels K2-K4) and 9 unimpaired participants (3 females, mean age 33 ± 10 years). The Initial Contact, Final Contact, and Total Contact times of 7 areas of the feet (unimpaired, intact, and prosthetic feet) were studied together with the duration of the Heel Rocker, Ankle Rocker, and Forefoot Rocker. Results were compared using a mixed analysis of the variance test.

Results:
Statistical analysis revealed an interaction (P < 0.05) between foot and areas. The contact times were different (P < 0.05) between unimpaired and prosthetic feet for most foot areas. Furthermore, the prosthetic foot showed the longest duration of Heel Rocker (21.1 ± 8.5% of stance phase vs. 17.7 ± 10.2% for the intact foot and 15.7 ± 8.8% for the unimpaired feet, P < 0.05) and the shortest duration of Ankle Rocker (43.8 ± 18.1% vs. 47.2 ± 16.9% for the intact foot and 50.0 ± 13.4% for the unimpaired feet, P < 0.05).

Conclusions:
Results suggest that the ESAR foot does not mimic the unimpaired foot rollover, especially in the contact pattern and the heel and ankle rockers. This might have an impact on efficiency and stability of gait.
Selective nonoperative management of abdominal gunshot wounds: What you need to know
Authors: Matsushima Kazuhide , Inaba Kenji 
Published: December 2024

ABSTRACT
Since the 1990s, there has been a slow but steady adoption of selective nonoperative management (SNOM) for abdominal gunshot wounds (GSW). Multiple studies have shown that SNOM is feasible and can be performed safely, even at trauma centers with low penetrating trauma volumes. The principles of SNOM for abdominal GSW consists of (1) careful patient selection, (2) diagnostic workup with CT, and (3) clinical observation. By implementing SNOM, the number of patients undergoing a nontherapeutic laparotomy can significantly be improved to less than 10%. Overall, approximately one third of patients with abdominal GSW can be managed nonoperatively. This review article provides a practical approach to the management of patients with an abdominal GSW.
Namibian fairy circles: Hostile territory for soil nematodes
Authors: Treonis Amy M. , Bell L. Andrew , Marais Eugene , Maggs-Kölling Gillian 
Published: December 2024

AbstractFairy circles are rings of grass with centers of bare soil that are found in some arid grasslands. Above- and belowground chemical and biological attributes of fairy circles have been explored in an ongoing debate about the ultimate causes of this pattern. We studied the soil nematode communities associated withStipagrostisfairy circles along a 900-km range in the Namib Desert of Namibia in southern Africa. Nematode abundance and diversity were highest in soils along the vegetation rings that define fairy circles and in soils in the vegetated matrix surrounding the bare circles, demonstrating the positive impact of plant-derived resources on nematode communities. In contrast, soils from the bare centers of fairy circles had lower organic matter content and were nearly defaunated, averaging only 9.9 ± 1.7 nematodes 100 g−1soil. Bacterial-feedingAcrobeloidesnematodes were the only taxa over-represented in center soils in comparison to ring soils. Our results indicate that nematode communities are influenced by the unique soil environments that the fairy circle vegetation pattern generates and suggest that the soils at the centers of fairy circles are uniquely hostile habitat for soil organisms as well as plants. Co-occurrence network analysis of nematode communities elucidated relationships among the taxa. For example, the abundances of dorylaims andNothacrobeleswere positively correlated across all soil positions, suggesting they have overlapping ecological niches. In ring soils, the abundances of fungal-feedingAphelenchoides,Ditylenchus, andHexatyluswere positively correlated, likely due to enhanced fungal communities in these plant-influenced soils.Panagrobelusdemonstrated niche specialization by being negatively correlated to two other bacterial-feeding taxa (Elaphonemain matrix soils andAcrobeloidesin ring soils). The co-occurrence patterns revealed by these relatively low diversity communities provide insights into the potential roles of nematode interactions as well as environmental factors in community assembly.