bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Evaluation of Fracture Resistance of Endodontically Treated Teeth Restored with Resin Fiber Post and Stainless Steel Post: An In Vitro Study
Authors: Singh Vijay , Bogra Poonam , Gupta Saurabh , Kukreja Navneet , Gupta Neha 
Published: October 2018

AbstractFracture resistance of endodontically treated teeth restored with post. Aims: This study aims to compare the fracture resistance of endodontically treated teeth restored with resin fiber and stainless steel post. Commercially available prefabricated resin fiber post(Dentsply Maillefer Easy Post), prefabricated stainless steel post(Coltene/Whaledent Parapost) were used. Methods and Material: Forty five maxillary central incisors were obturated and divided into 3 groups: Control Group (Group I) without any post (n = 15), Resin Fiber Post Group (Group II) (n = 15) and Stainless Steel Post Group (Group III) (n = 15). In all Groups except control group, post space was prepared; a post was cemented, and a core build-up was provided. All the specimens were subjected to compressive force under a universal testing machine until fracture. Statistical analysis used: The results were analyzed using the variable analysis test (ANOVA). Results: One-way analysis of variance revealed significant difference among test groups. The control group demonstrated highest fracture resistance (925.2183 N), followed by the resin fiber post group (486.7265 N) and stainless steel post group (423.539N). Conclusions: Teeth restored with resin fiber post showed higher fracture resistance values than prefabricated stainless steel post.
An Overview of Zirconia and its Application in Dentistry
Authors: Kumar Manjit , Razdan Sonali , Sharma Arvind 
Published: October 2018

AbstractTo replace metallic dental prosthesis the structure of ceramics has been improved. Among in Ceramics Zirconia has come up in a big way because of its biological, mechanical and optical properties. It has adequate mechanical properties to be used in medical devices. With addition of yittrium trioxide properties of zirconia improved tremendously to be used in dentistry. This review article gives general properties as well as specific clinical guidelines for its use in dentistry.
Root Resorption Associated with Orthodontic Tooth Movement: A Review
Authors: Gupta Vivek , Dhaliwal Yadvinder , Dhaliwal Ambika 
Published: October 2018

AbstractRoot resorption is one of the most common and serious side effect commonly associated with orthodontic treatment. Numerous studies have associated root resorption with multiple factors during course of orthodontic treatment, but no clear cause and effect relationship has been demonstrated. Various factors like individual susceptibility, systemic factors, appliance type, tooth movement and force applied play a major role. This article attempts to review the literature regarding root resorption with various factors associated with orthodontic treatment.
Comparison Between Prescription of Regular or on-Demand Ibuprofen on Postoperative Pain after Single-Visit Root Canal Treatment of Teeth with Irreversible Pulpitis
Authors: Nabhi Kamal , Chhabra Ajay , Jindal Varun , Singh Simran ,   Damanpreet
Published: October 2018

Abstract
Purpose: Prevention and management of postendodontic pain (PEP) is an integral part of endodontic treatment. NSAIDs such as Ibuprofen, Ketorolac are the most common medications used for managing pain after root canal treatment. So the purpose of this study was to compare the effect of pain relief on regular versus on demand prescription of ibuprofen after single-visit root canal treatment in teeth with irreversible pulpitis. Materials & Methodology: The study was performed on twenty patients. Root canal treatment was performed and all the patients were given a ‘‘rescue bag’’ that contained 8 tablets of 400 mg ibuprofen and then divided into two groups. In the group 1- patients were instructed to use ibuprofen tablets if they felt pain and in the group 2- patients were instructed to take ibuprofen regularly after every 6 hours for at least three days. Patients were instructed to complete a form to rate their pain at 24 and 48 hours after the root canal treatment and were also asked to record the number of analgesic tablets they had taken. Records were collected and statistically analysed. Results: The patients’ pain levels in groups 1 and 2 were not significantly different at 24 and 48 hours after root canal treatment. The number of analgesic medications used by the patients in group 2 was significantly higher than the other group. Conclusion: Regular prescription of ibuprofen had no significant effect on postoperative pain compared with on-demand use of ibuprofen in teeth with irreversible pulpitis
rhPDGF Mediated Root Coverage Procedure Using Coronally Advanced Flap in Treatment of Multiple Recession Defects: A Case Report
Authors: Singh Preetinder , Dev Yash , Nitin Khuller , Singh Anahita , Kaur Prabhjot , Singh Yashbir 
Published: October 2018

AbstractGingival recession has been defined as the term used to characterize the apical shift of the marginal gingiva from its normal position on the crown of the tooth to levels on the root surface beyond the cemento-enamel junction (CEJ). Numerous techniques have been developed for treatment of these defects including rotational and advanced gingival flaps, soft-tissue grafting procedures with autogenous and allograft materials. This paper illustrates a case report of 42-years-old male patient with a chief complaint of thermal root sensitivity in relation with front teeth of lower jaw and describes a technique to coronally advance the flap in combination with recombinant human platelet-derived growth factor-BB (rhPDGF-BB) (GEM 21S®) to treat multiple gingival recession defects. Patient was followed postoperatively, and healing was evaluated at 1, 3 and 6 months, with recession depth as the primary outcome measure. This case report revealed a favourable tissue response to GEM 21S® from both clinical and aesthetic points of view showing excellent plastic surgery results for gingiva.
Dental Management of a Patient with Congenital Hypothyroidism: A Case Report
Authors: Singhal Monisha , Singh Nitin , Rohit Anand , Chaudhary C. 
Published: October 2018

AbstractCongenital hypothyroidism (CHT) is one of the most common thyroid disorders. It occurs because of dysgenesis of thyroid gland which is responsible for the normal development of neural system. Child patient suffering from congenital hypothyroidism shows various medical and behavioral symptoms which makes routine dental care very challenging to the pediatric dentist. Due to increased awareness and introduction of neonatal screening, the long term hypothyroidism has become rare. The most significant oral conditions related to these patients are delayed eruption and dental caries. The present case report outlines the dental treatment of a 9yr old girl with congenital hypothyroidism.
Current Concepts and Trends in Biomechanics and Biomaterials of Oral and Maxillofacial Implants
Authors: Jindal Neha , Kumar Manjit ,   Ramandeep
Published: October 2018

AbstractThe science of Implantology has undergone numerous modifications and improvement and is highly dynamic. With each improvement and advancement, Implantology has proved to be a boon in disguise to the society and hence its acceptance by the general population has widely increased despite of expensive treatment modality. More of clinical trials conducted on different commercially available implants, its effect on bone and oral tissues as well as the development of implant designs, have increased the success rate of implants to over 95% and specially in anterior mandible where the success rate is over 99%. Latest technological advances in Dental Implantology are reviewed in this article.
Management of Iatrogenic Furcation Perforation in Mandibular First Molar With Biodentine- Two Years Follow Up
Authors: Thakur Savita , Rani Anuradha , Garg Nisha ,   Damanpreet
Published: October 2018

AbstractSuccessful management of furcation perforations poses a challenge for a clinician. The perforation can result from iatrogenic causes, caries or resorption. It is advisable to repair the perforation as soon as it is identified, since any delay allows the bacterial ingress leading to a complicated endodontic–periodontal lesion and ultimately in the treatment failure. This case report describes successful management of a furcal perforation in a mandibular first molar, which was repaired using Biodentine. The endodontic treatment was completed and the tooth was coronally restored with composite followed by full coverage restoration. Two years follow up of the case showing absence of pain; periradicular healing of the lesion, along with functional tooth stability indicated a successful outcome of endodontic treatment and sealing the perforation using Biodentine.
“Epidermoid Cyst of Hard Palate and Evaluation of Healing by Color Power Doppler Ultrasonography: A Case Report
Authors: Chauhan Sanjeev , Gupta Ashu , Sharma Vishal , Aggarwal Neeti 
Published: October 2018

AbstractEpidermoid cyst is a rare developmental cyst of the oro-facial region which results from entrapped epidermal elements with an incidence of 6.9-7% and represents less than 0.01% of all oral cavity cysts. PRF, as a physiologic fibrin matrix, serves as a net to stem cells, especially when an accelerated angiogenesis develops in the fibrin membrane. This aspect is of particular interest in the case of wide osseous defects. The Color Power Doppler detects minute areas of blood flow and the velocity of blood flow in healing bone by recording the change in frequency caused by the moving red blood cells. It demonstrates the progressive formation of new vessels in bone during the initial healing period. As the bone remodelling proceeds, there is a decrease in flow signals.
Giant Calvarial Ewing's Sarcoma: A Case Report
Authors: Sarigul Buse , Uysal Ece , Avci İdris , Peker Halil , Celik Suat 
Published: October 2018

AbstractEwing's sarcoma (EWS) is the second most common primary bone tumor seen in children and adolescents, first being osteosarcoma. Skull lesions are seen in 6 to 9% of cases. The tumor tends to reside most frequently on frontal and parietal bones. In the literature, majority of papers on calvarial EWS present cases with intracranial involvement; extracranial extension is reported in only eight cases. The case that we are presenting in this report is a 23-year-old male patient with multiple infiltrations in femur, costal bones, and calvarium which had been diagnosed radiologically and histopathologically as EWS. The calvarial metastasis had reached a very huge size with dimensions of approximately 7.5 × 7.5 × 9.5 cm and was successfully excised totally. Twelve months of follow-up revealed no recurrence in the surgical site showing that total removal of giant cranial EWS may improve morbidity of these patients.
The academic English collocation list
Authors: Lei Lei , Liu Dilin 
Published: October 2018

AbstractThe use of collocations plays an important role for the proficiency of ESL/EFL learners. Hence, educators and researchers have long tried to identify collocations typical of either academic or general English and the challenges involved in learning them. This paper proposes a comprehensive and type-balanced academic English collocation list (AECL). AECL is based on a large corpus of academic English and was created to cover the types of collocations that will be most useful to ESL/EFL learners. AECL is the result of an innovative research-based procedure that involves a five-step selection method. A comparison of the collocations on AECL with those found in well-known collocation dictionaries of general English and on three existing academic English collocation lists indicates that AECL indeed contains mainly academic rather than general English collocations. In addition, AECL is more comprehensive with regard to the types of collocations that are relevant to learners.
On the evolution of hydrological modelling for water resources in Eastern Africa.
Authors: Senkondo W. , Tumbo M. , Lyon S. W. 
Published: October 2018

Abstract

This review provides an assessment of the evolution of hydrological modelling for Eastern Africa. We outline the historical development and perspectives considered as this region, like many regions around the world, sees increasing attention on how water resources can be sustainably developed. We emphasize the spatial scales and modelling approaches that typify the region and how these have changed with time. The review is done in two complementary approaches. The first approach is to explore a practical, real-world example providing context for the Eastern Africa region and the water resource development issues presently faced. We use Tanzania's 34 000 km
2
Kilombero Valley (KV) river basin to explore implications of significant gaps in data and modelling scales. We hypothesize that these gaps limit the application of the current state-of-the-science to inform water management policy and practice under current and estimated future conditions. In our second approach, we investigate possible solutions to bridge these gaps through a review of case studies from other Eastern Africa's basins across a range of sizes. Our result highlight that some applications of the models considered under this review anticipated more recent international developments as indicated in Predictions in Ungauged Basins and Panta Rhei initiatives. Through this review, it is clear that there is a possibility to improve understanding of the hydrological processes relevant at scales such as the KV river basin through the use of (1) global precipitation datasets (e.g. satellite and/or homogenized observed data) as input data; (2) remote sensing datasets as model evaluation variable; (3) regionalization around the transferability of model parameters; (4) modification of model codes/structures to suit local conditions; and (5) understanding and application of uncertainty principles in hydrological modelling. Given that many regions of the world face similar water resource management challenges as Eastern Africa; it is likely that the findings of this review could help guide how we develop the next generation of modelling approaches to leverage information from various scales.
Identification and expression analysis of MinD gene involved in plastid division in cassava
Authors: Ke Lei , Cao Liang-Jing , Geng Meng-Ting , Wang Cong-Cong , Yao Yuan , Xiao Yu , Huang Wu , Li Rui-Mei , Min Yi , Guo Jian-Chun 
Published: October 2018

ABSTRACT
Cassava is a tropical crop known for its starchy root and excellent properties. Considering that starch biosynthesis in the amyloplast is affected by its division, it appears conceivable that the regulation of plastid division plays an important role in starch accumulation. As a member of the Min system genes, MinD participated in the spatial regulation of the position of the plastid division site.In our studies, sequence analysis and phylogenetic analysis showed that MeMinD has been highly conserved during the evolutionary process. Subcellular localisation indicated that MeMinD carries a chloroplast transit peptide and was localised in the chloroplast. Overexpression of MeMinD resulted in division site misplacement and filamentous formation in E. coli, indicating that MeMinD protein was functional across species. MeMinD exhibited different spatial and temporal expression patterns which was highly expressed in the source compared to that in the sink organ.
Japanese Rice Wine can reduce psychophysical stress-induced depression-like behaviors and Fos expression in the trigeminal subnucleus caudalis evoked by masseter muscle injury in the rats
Authors: Nakatani Yosuke , Kakihara Yoshito , Shimizu Shiho , Kurose Masayuki , Sato Tsutomu , Kaneoke Mitsuoki , Saeki Makio , Takagi Ritsuo , Yamamura Kensuke , Okamoto Keiichiro 
Published: October 2018

ABSTRACT
We determined if Japanese Rice Wine (Sake) had inhibitory effects on stress-induced enhancement of masseter muscle (MM) nociception in the rats. Male rats were subjected to the repeated forced swim stress (FS) or sham conditionings from Day −3 to −1. Daily administration of Sake or saline was conducted after each stress conditioning. At Day 0 the number of Fos positive cells, a marker for neural activity, was quantified at the trigeminal subnucleus caudalis (Vc) region by MM injury with formalin. FS increased MM-evoked Fos expression in the Vc region, which was inhibited by Sake compared to saline administration. Sake did not alter the number of Fos positive cells under sham conditions, indicating that inhibitory roles of Sake on neural activity in the Vc region were seen under FS conditions. These findings indicated that Sake had inhibitory roles on stress-induced MM nociception at the Vc region in our experimental conditions.
Construction of a potato fraction library for the investigation of functional secondary metabolites
Authors: Nogawa Toshihiko , Futamura Yushi , Okano Akiko , Suto Mari , Nakamura Junya , Ishihara Katsuyuki , Osada Hiroyuki 
Published: October 2018

ABSTRACT
A potato fraction library was constructed to investigate functional secondary metabolites from 8 cultivars: Kitahime, Pilka, Sakurafubuki, Atlantic, Toyoshiro, Snowden, Kitamurasaki, and Northern Ruby, which were divided into flower, leaf, stem, roots, tuber peel, and tuber. Each fraction was a semi-purified extract and about 800 fractions were prepared for the library. They were analyzed by DAD-LC/MS to obtain structural information and were evaluated for various biological activities. LC/MS data showed that each part had a specific characteristic for their constituents supported by principal component analysis (PCA). Approximately 40% of fractions showed significant biological activities at 30 μg/mL, especially the flower fractions showed strong cytotoxicity. PCAs based on the activity and LC/MS data suggested that the strong cytotoxicity of flowers was derived from a complex mixture of potato glycoalkaloids. In addition, tuber peel fractions showed strong antimalarial activity, which had not been reported before. Also, some fractions showed significant antibacterial activities.
Anti-inflammatory effects of Kaempferol onHelicobacter pylori-induced inflammation
Authors: Yeon Min Ji , Lee Min Ho , Kim Do Hyun , Yang Ji Yeong , Woo Hyun Jun , Kwon Hye Jin , Moon Cheol , Kim Sa-Hyun , Kim Jong-Bae 
Published: October 2018

ABSTRACTInflammation induced by Helicobacter pylori infection related to gastric carcinogenesis. In this study, we have investigated the anti-inflammatory effect and its mechanism of kaempferol in the inflammatory response caused by H. pylori infection in vitro. We found that kaempferol reduced the expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-8) and production of IL-8 in AGS cells. In addition, kaempferol suppressed translocation of cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA) of H. pylori to AGS cells. It was due to decreased transcription of type IV secretion system (T4SS) components involved in CagA injection and secretion system subunit protein A (SecA) of type V secretion system (T5SS) involved in VacA secretion by kaempferol. In conclusion, kaempferol shows the anti-inflammatory effect by suppressing the translocation of CagA and VacA proteins and leading to the down-regulation of pro-inflammatory cytokines.Abbreviations: CagA: cytotoxin-associated gene A; VacA: vacuolating cytotoxin A; T4SS: type IV secretion systems; SecA: secretion system subunit protein A; T5SS: type V secretion system;
Selectivity Conversion of Protease Inhibitory Antibodies
Authors: Lopez Tyler , Ramirez Aaron , Benitez Chris , Mustafa Zahid , Pham Henry , Sanchez Ramon , Ge Xin 
Published: October 2018

ABSTRACT
Background: Proteases are one of the largest pharmaceutical targets for drug developments. Their dysregulations result in a wide variety of diseases. Because proteolytic networks usually consist of protease family members that share high structural and catalytic homology, distinguishing them using small molecule inhibitors is often challenging. To achieve specific inhibition, this study described a novel approach for the generation of protease inhibitory antibodies. As a proof of concept, we aimed to convert a matrix metalloproteinase (MMP)-14 specific inhibitor to MMP-9 specific inhibitory antibodies with high selectivity.
Methods: An error-prone single-chain Fv (scFv) library of an MMP-14 inhibitor 3A2 was generated for yeast surface display. A dual-color competitive FACS was developed for selection on MMP-9 catalytic domain (cdMMP-9) and counter-selection on cdMMP-14 simultaneously, which were fused/conjugated with different fluorophores. Isolated MMP-9 inhibitory scFvs were biochemically characterized by inhibition assays on MMP-2/-9/-12/-14, proteolytic stability tests, inhibition mode determination, competitive ELISA with TIMP-2 (a native inhibitor of MMPs), and paratope mutagenesis assays.
Results: We converted an MMP-14 specific inhibitor 3A2 into a panel of MMP-9 specific inhibitory antibodies with dramatic selectivity shifts of 690–4,500 folds. Isolated scFvs inhibited cdMMP-9 at nM potency with high selectivity over MMP-2/-12/-14 and exhibited decent proteolytic stability. Biochemical characterizations revealed that these scFvs were competitive inhibitors binding to cdMMP-9 near its reaction cleft via their CDR-H3s.
Conclusions: This study developed a novel approach able to convert the selectivity of inhibitory antibodies among closely related protease family members. This methodology can be directly applied for mAbs inhibiting many proteases of biomedical importance.
Statement of Significance To achieve high selectivity required for therapies, we developed a novel approach for the generation of protease inhibitory antibodies with nM potency and decent proteolytic stability. The methodology demonstrated here can be readily applied to many proteases of biomedical importance.
Accurate detection of chimeric contigs via Bionano optical maps
Authors: Pan Weihua , Lonardi Stefano 
Published: October 2018

Abstract

Summary
A chimeric contig is contig that has been incorrectly assembled, i.e. a contig that contains one or more mis-joins. The detection of chimeric contigs can be carried out either by aligning assembled contigs to genome-wide maps (e.g. genetic, physical or optical maps) or by mapping sequenced reads to the assembled contigs. Here, we introduce a software tool called Chimericognizer that takes advantage of one or more Bionano Genomics optical maps to accurately detect and correct chimeric contigs. Experimental results show that Chimericognizer is very accurate, and significantly better than the chimeric detection method offered by the Bionano Hybrid Scaffold pipeline. Chimericognizer can also detect and correct chimeric optical molecules.

Availability and implementation
https://github.com/ucrbioinfo/Chimericognizer

Supplementary information
Supplementary data are available at Bioinformatics online.