bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors associated with seropositivity to California serogroup viruses in humans and pet dogs, Quebec, Canada
Authors: Rocheleau J. P. , Michel P. , Lindsay L. R. , Drebot M. , Dibernardo A. , Ogden N. H. , Fortin A. , Arsenault J. 
Published: May 2018

AbstractJamestown Canyon and snowshoe hare viruses are two emerging human pathogens associated with cases of neuroinvasive disease in North America. This study aimed to identify environmental and individual risk factors for seropositivity to these arboviruses in humans and pet dogs from Québec, Canada, 2012–2014. In humans, areas with moderate densities of white-tailed deer (Odocoileus virginianus) were associated with higher odds of seropositivity compared with areas with low densities of white-tailed deer (OR 2.50, P = 0.009) and odds of seropositivity were higher in males than in females (OR 2.03, P = 0.016). Among humans reporting more than 10 mosquito bites weekly, the odds of being seropositive were 4.44 times higher (P = 0.004) for people living in hardwood forested areas. Exposure to areas with coniferous forests was identified as the main environmental risk factor for seroconversion in dogs (OR 2.39, P = 0.04). These findings may help target further public health research, diagnostic and surveillance efforts in Canada.
Cognitive remediation in large systems of psychiatric care
Authors: Medalia Alice , Saperstein Alice M. , Erlich Matthew D. , Sederer Lloyd I. 
Published: May 2018

IntroductionWith the increasing enthusiasm to provide cognitive remediation (CR) as an evidence-based practice, questions arise as to what is involved in implementing CR in a large system of care. This article describes the first statewide implementation of CR in the USA, with the goal of documenting the implementation issues that care providers are likely to face when bringing CR services to their patients.MethodsIn 2014, the New York State Office of Mental Health set up a Cognitive Health Service that could be implemented throughout the state-operated system of care. This service was intended to broadly address cognitive health, to assure that the cognitive deficits commonly associated with psychiatric illnesses are recognized and addressed, and that cognitive health is embedded in the vocabulary of wellness. It involved creating a mechanism to train staff to recognize how cognitive health could be prioritized in treatment planning as well as implementing CR in state-operated adult outpatient psychiatry clinics.ResultsBy 2017, CR was available at clinics serving people with serious mental illness in 13 of 16 adult Psychiatric Centers, located in rural and urban settings throughout New York state. The embedded quality assurance program evaluation tools indicated that CR was acceptable, sustainable, and effective.ConclusionsCognitive remediation can be feasibly implemented in large systems of care that provide a multilevel system of supports, a training program that educates broadly about cognitive health and specifically about the delivery of CR, and embedded, ongoing program evaluation that is linked to staff supervision.
On the Role of Lower Crust and Midlithosphere Discontinuity for Cratonic Lithosphere Delamination and Recycling
Authors: Wang Zhensheng , Kusky Timothy M. , Capitanio Fabio A. 
Published: May 2018

AbstractDelamination is an important mechanism of continental lithosphere removal and recycling. It has been invoked as a likely cause for the observed thinning in the eastern North China (North China Craton) and several other cratons, returning thick depleted cratonic roots to the deep mantle. However, how delamination occurred, its lateral extent, and detachment depth of delamination are still debated. Here we test this process by means of 2‐D numerical modeling and find that delamination below lower crustal depths can only initiate near cratonic margins, where thickening‐induced eclogitization can significantly destabilize the lower part of the lithosphere, allowing it to detach and leading to intraplate orogeny. When a weak midlithosphere discontinuity is present, widespread delamination can initiate near cratonic margins and easily propagate to cratonic interiors, yet without obvious intraplate deformation. We illustrate how this delamination mechanism can recycle large volumes of depleted Archean subcontinental lithospheric mantle using numerical models. Our models explain the large‐scale delamination in the North China Craton, where a midlithosphere discontinuity is inferred by geophysical studies and shows that large portions of subcontinental lithospheric mantle can be recycled in the deep mantle potentially affecting mantle heterogeneity.
Evaluating Controls on Nutrient Retention and Export in Wide and Narrow Valley Segments of a Mountain River Corridor
Authors: Wegener Pam , Covino Tim , Rhoades Charles 
Published: May 2018

AbstractOver the past few decades, nitrate‐nitrogen (NO3‐N) concentrations have increased within streams of the central Rockies, a pattern linked to regional N deposition trends. As NO3‐N concentrations increase, in‐stream biological demand may become saturated and stream N export may increase. In mountain landscapes, streams generally flow through steep, narrow valleys with limited riparian area and strong stream‐hillslope connectivity. Interspersed between the narrow valleys are wide segments where substantial floodplain riparian areas can develop. Here, we coupled measures of stream reach NO3‐N flux balances with nutrient enrichment experiments along two stream reaches of contrasting valley morphology in Rocky Mountain National Park. The stream reaches were (1) a narrow valley segment with limited floodplain riparian area and (2) a longitudinally adjacent (directly downstream) wide valley segment with extensive floodplain riparian area. We found that in‐stream biological uptake of added NO3‐N was limited in both segments, presumably as a consequence of saturating conditions. Assessment of mass flux indicated that the narrow valley segment was a consistent source of water and NO3‐N across flow states, while the wide segment was a sink at high flow and a source at low flow. Due to low in‐stream biological retention, gross gains and losses of water and NO3‐N to and from the stream exerted primary constraint on segment mass balances. Our results suggest that the exchange of water and nutrients between the stream and adjacent landscape can exert strong control on reach‐scale nutrient export, particularly in streams experiencing or approaching N saturation.
Underestimated AMOC Variability and Implications for AMV and Predictability in CMIP Models
Authors: Yan Xiaoqin , Zhang Rong , Knutson Thomas R. 
Published: May 2018

AbstractThe Atlantic Meridional Overturning Circulation (AMOC) has profound impacts on various climate phenomena. Using both observations and simulations from the Coupled Model Intercomparison Project Phase 3 and 5, here we show that most models underestimate the amplitude of low‐frequency AMOC variability. We further show that stronger low‐frequency AMOC variability leads to stronger linkages between the AMOC and key variables associated with the Atlantic multidecadal variability (AMV), and between the subpolar AMV signal and northern hemisphere surface air temperature. Low‐frequency extratropical northern hemisphere surface air temperature variability might increase with the amplitude of low‐frequency AMOC variability. Atlantic decadal predictability is much higher in models with stronger low‐frequency AMOC variability and much lower in models with weaker or without AMOC variability. Our results suggest that simulating realistic low‐frequency AMOC variability is very important, both for simulating realistic linkages between AMOC and AMV‐related variables and for achieving substantially higher Atlantic decadal predictability.
Meridional Overturning Circulation Transport Variability at 34.5°S During 2009–2017: Baroclinic and Barotropic Flows and the Dueling Influence of the Boundaries
Authors: Meinen Christopher S. , Speich Sabrina , Piola Alberto R. , Ansorge Isabelle , Campos Edmo , Kersalé Marion , Terre Thierry , Chidichimo Maria Paz , Lamont Tarron , Sato Olga T. , Perez Renellys C. , Valla Daniel , van den Berg Marcel , Le Hénaff Matthieu , Dong Shenfu , Garzoli Silvia L. 
Published: May 2018

AbstractSix years of simultaneous moored observations near the western and eastern boundaries of the South Atlantic are combined with satellite winds to produce a daily time series of the basin‐wide meridional overturning circulation (MOC) volume transport at 34.5°S. The results demonstrate that barotropic and baroclinic signals at both boundaries cause significant transport variations, and as such must be concurrently observed. The data, spanning ~20 months during 2009–2010 and ~4 years during 2013–2017, reveal a highly energetic MOC record with a temporal standard deviation of 8.3 Sv, and strong variations at time scales ranging from a few days to years (peak‐to‐peak range = 54.6 Sv). Seasonal transport variations are found to have both semiannual (baroclinic) and annual (Ekman and barotropic) timescales. Interannual MOC variations result from both barotropic and baroclinic changes, with density profile changes at the eastern boundary having the largest impact on the year‐to‐year variations.
Long‐Term Variation in the Mixing Fraction of Tropospheric and Stratospheric Air Masses in the Upper Tropical Tropopause Layer
Authors: Inai Yoichi 
Published: May 2018

AbstractObservational records of the stratospheric mean age of air (AoA), the average transit time of an air parcel since entering the stratosphere, must reflect changes in the in‐mixing from the extratropical lower stratosphere to the tropical tropopause layer (TTL). Focusing on the mixing fraction of tropospheric and stratospheric air masses in the upper TTL, the impact of mixing processes that occur prior to air masses entering the stratosphere separately from those that occur within the stratosphere is investigated. Using trajectory analysis, the mixing fraction during 1980–2016 is evaluated, and AoA and water vapor mixing ratios in the upper TTL are reconstructed. The interannual variation in the reconstructed water vapor shows good agreement with observations in the tropics. Furthermore, the reconstructed AoA exhibits long‐term variation with a positive trend between 1980 and 1999. To compare the reconstructed AoA with the observed AoA in the midlatitude stratosphere, the transit time spectra are estimated for the 1989–2016 period, and the AoA in the midlatitude stratosphere is estimated by integration of the spectrum together with the AoA in the upper TTL. As a result, although the explicitly calculated transit time shows a clear underestimation compared with previous studies, it is suggested that the “aging” effects are 3.1–4.2 years for transit time in the stratosphere, 0.2–0.7 years for in‐mixing prior to entering the stratosphere, 0.1 years for transit time from the troposphere to upper TTL, and 0.0–1.6 years for subgrid‐scale mixing in the stratosphere.
Formation and radiative forcing of contrail cirrus
Authors: Kärcher Bernd 
Published: May 2018

AbstractAircraft-produced contrail cirrus clouds contribute to anthropogenic climate change. Observational data sets and modelling approaches have become available that clarify formation pathways close to the source aircraft and lead to estimates of the global distribution of their microphysical and optical properties. While contrail cirrus enhance the impact of natural clouds on climate, uncertainties remain regarding their properties and lifecycle. Progress in representing aircraft emissions, contrail cirrus and natural cirrus in global climate models together with tighter constraints on the sensitivity of the climate system will help judge efficiencies of and trade-offs between mitigation options.
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition
Authors: Koliopoulos Marios G. , Lethier Mathilde , van der Veen Annemarthe G. , Haubrich Kevin , Hennig Janosch , Kowalinski Eva , Stevens Rebecca V. , Martin Stephen R. , Reis e Sousa Caetano , Cusack Stephen , Rittinger Katrin 
Published: May 2018

AbstractRIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin chains, synthesised by TRIM25, is crucial for activation of the RIG-I/MAVS signalling pathway. TRIM25 activity is targeted by influenza A virus non-structural protein 1 (NS1) to suppress IFN production and prevent an efficient host immune response. Here we present structures of the human TRIM25 coiled-coil-PRYSPRY module and of complexes between the TRIM25 coiled-coil domain and NS1. These structures show that binding of NS1 interferes with the correct positioning of the PRYSPRY domain of TRIM25 required for substrate ubiquitination and provide a mechanistic explanation for how NS1 suppresses RIG-I ubiquitination and hence downstream signalling. In contrast, the formation of unanchored K63-linked poly-ubiquitin chains is unchanged by NS1 binding, indicating that RING dimerisation of TRIM25 is not affected by NS1.
Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure
Authors: Abudureyimu Shaniya , Asai Naoya , Enomoto Atsushi , Weng Liang , Kobayashi Hiroki , Wang Xiaoze , Chen Chen , Mii Shinji , Takahashi Masahide 
Published: May 2018

AbstractLinx is a member of the leucine-rich repeat and immunoglobulin family of membrane proteins which has critical roles in the development of the peripheral nervous system and forebrain connectivity. A previous study showed that Linx is expressed in projection neurons in the cortex and in cells that comprise the passage to the prethalamus that form the internal capsule, indicating the involvement of Linx in axon guidance and cell-cell communication. In this study, we found that Linx-deficient mice develop severe hydrocephalus and die perinatally by unknown mechanisms. Importantly, mice heterozygous for the linx gene exhibited defects in the development of the anterior commissure in addition to hydrocephalus, indicating haploinsufficiency of the linx gene in forebrain development. In N1E-115 neuroblastoma cells and primary cultured hippocampal neurons, Linx depletion led to impaired neurite extension and an increase in cell body size. Consistent with this, but of unknown significance, we found that Linx interacts with and upregulates the activity of Rho-kinase, a modulator of many cellular processes including cytoskeletal organization. These data suggest a role for Linx in the regulation of complex forebrain connectivity, and future identification of its extracellular ligand(s) will help clarify this function.
Identifying microRNA determinants of human myelopoiesis
Authors: Rajasekhar Megha , Schmitz Ulf , Flamant Stephane , Wong Justin J.-L. , Bailey Charles G. , Ritchie William , Holst Jeff , Rasko John E. J. 
Published: May 2018

AbstractMyelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes and granulocytes. This complex process is regulated by various extracellular and intracellular signals including microRNAs (miRNAs). We characterised the miRNA profile of human CD34+CD38+ myeloid progenitor cells, and mature monocytes and granulocytes isolated from cord blood using TaqMan Low Density Arrays. We identified 19 miRNAs that increased in both cell types relative to the CMP and 27 that decreased. miR-125b and miR-10a were decreased by 10-fold and 100-fold respectively in the mature cells. Using in vitro granulopoietic differentiation of human CD34+ cells we show that decreases in both miR-125b and miR-10a correlate with a loss of CD34 expression and gain of CD11b and CD15 expression. Candidate target mRNAs were identified by co-incident predictions between the miRanda algorithm and genes with increased expression during differentiation. Using luciferase assays we confirmed MCL1 and FUT4 as targets of miR-125b and the transcription factor KLF4 as a target of miR-10a. Together, our data identify miRNAs with differential expression during myeloid development and reveal some relevant miRNA-target pairs that may contribute to physiological differentiation.
Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications
Authors: Idris Maizlinda I. , Zaloga Jan , Detsch Rainer , Roether Judith A. , Unterweger Harald , Alexiou Christoph , Boccaccini Aldo R. 
Published: May 2018

AbstractSurface modification of superparamagnetic iron oxide nanoparticles (SPIONs) has been introduced with lauric acid and oleic acid via co-precipitation and thermal decomposition methods, respectively. This modification is required to increase the stability of SPIONs when incorporated in hydrophobic, biodegradable and biocompatible polymers such as poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this work, the solid-in-oil-in-water (S/O/W) emulsion-solvent extraction/evaporation method was utilized to fabricate magnetic polymer microspheres incorporating SPIONs in PHBV. The prepared magnetic PHBV microspheres exhibited particle sizes <1 µm. The presence of functional groups of lauric acid, oleic acid and iron oxide in the PHBV microspheres was confirmed by Fourier Transform Infrared spectroscopy (FTIR). X-ray diffraction (XRD) analysis was performed to further confirm the success of the combination of modified SPIONs and PHBV. Thermogravimetric analysis (TGA) indicated that PHBV microspheres were incorporated with SPIONsLauric as compared with SPIONsOleic. This was also proven via magnetic susceptibility measurement as a higher value of this magnetic property was detected for PHBV/SPIONsLauric microspheres. It was revealed that the magnetic PHBV microspheres were non-toxic when assessed with mouse embryotic fibroblast cells (MEF) at different concentrations of microspheres. These results confirmed that the fabricated magnetic PHBV microspheres are potential candidates for use in biomedical applications.
Acute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice
Authors: Jackson Travis C. , Dixon C. Edward , Janesko-Feldman Keri , Vagni Vincent , Kotermanski Shawn E. , Jackson Edwin K. , Kochanek Patrick M. 
Published: May 2018

AbstractSuprachiasmatic nucleus circadian oscillatory protein (SCOP) (a.k.a. PHLPP1) regulates long-term memory consolidation in the brain. Using a mouse model of controlled cortical impact (CCI) we tested if (1) brain tissue levels of SCOP/PHLPP1 increase after a traumatic brain injury (TBI), and (2) if SCOP/PHLPP1 gene knockout (KO) mice have improved (or worse) neurologic outcomes. Blood chemistry (pH, pCO2, pO2, pSO2, base excess, sodium bicarbonate, and osmolarity) and arterial pressure (MAP) differed in isoflurane anesthetized WT vs. KOs at baseline and up to 1 h post-injury. CCI injury increased cortical/hippocampal SCOP/PHLPP1 levels in WTs 7d and 14d post-injury. Injured KOs had higher brain tissue levels of phosphorylated AKT (pAKT) in cortex (14d post-injury), and higher levels of phosphorylated MEK (pMEK) in hippocampus (7d and 14d post-injury) and in cortex (7d post-injury). Consistent with an important role of SCOP/PHLPP1 on memory function, injured-KOs had near normal performance on the probe trial of the Morris water maze, whereas injured-WTs were impaired. CA1/CA3 hippocampal survival was lower in KOs vs. WTs 24 h post-injury but equivalent by 7d. No difference in 21d cortical lesion volume was detected. SCOP/PHLPP1 overexpression in cultured rat cortical neurons had no effect on 24 h cell death after a mechanical stretch-injury.
Predictors of In-Hospital Mortality among Patients with Pulmonary Tuberculosis: A Systematic Review and Meta-analysis
Authors: de Almeida Carlos Podalirio Borges , Ziegelmann Patrícia Klarmann , Couban Rachel , Wang Li , Busse Jason Walter , Silva Denise Rossato 
Published: May 2018

AbstractBackground: There is uncertainty regarding which factors are associated with in-hospital mortality among patients with pulmonary TB (PTB). The aim of this systematic review and meta-analysis is to identify predictors of in-hospital mortality among patients with PTB. Methods: We searched MEDLINE, EMBASE, and Global Health, for cohort and case-control studies that reported risk factors for in-hospital mortality in PTB. We pooled all factors that were assessed for an association, and presented relative associations as pooled odds ratios (ORs). Results: We identified 2,969 records, of which we retrieved 51 in full text; 11 cohort studies that evaluated 5,468 patients proved eligible. Moderate quality evidence suggested an association with co-morbid malignancy and in-hospital mortality (OR 1.85; 95% CI 1.01–3.40). Low quality evidence showed no association with positive sputum smear (OR 0.99; 95% CI 0.40–2.48), or male sex (OR 1.09, 95% CI 0.84–1.41), and very low quality evidence showed no association with diabetes mellitus (OR 1.31, 95% IC 0.38–4.46), and previous TB infection (OR 2.66, 95% CI 0.48–14.87). Conclusion: Co-morbid malignancy was associated with increased risk of in-hospital death among pulmonary TB patients. There is insufficient evidence to confirm positive sputum smear, male sex, diabetes mellitus, and previous TB infection as predictors of in-hospital mortality in TB patients.
Sub-paresthesia spinal cord stimulation reverses thermal hyperalgesia and modulates low frequency EEG in a rat model of neuropathic pain
Authors: Koyama Suguru , Xia Jimmy , Leblanc Brian W. , Gu Jianwen Wendy , Saab Carl Y. 
Published: May 2018

AbstractParesthesia, a common feature of epidural spinal cord stimulation (SCS) for pain management, presents a challenge to the double-blind study design. Although sub-paresthesia SCS has been shown to be effective in alleviating pain, empirical criteria for sub-paresthesia SCS have not been established and its basic mechanisms of action at supraspinal levels are unknown. We tested our hypothesis that sub-paresthesia SCS attenuates behavioral signs of neuropathic pain in a rat model, and modulates pain-related theta (4–8 Hz) power of the electroencephalogram (EEG), a previously validated correlate of spontaneous pain in rodent models. Results show that sub-paresthesia SCS attenuates thermal hyperalgesia and power amplitude in the 3–4 Hz range, consistent with clinical data showing significant yet modest analgesic effects of sub-paresthesia SCS in humans. Therefore, we present evidence for anti-nociceptive effects of sub-paresthesia SCS in a rat model of neuropathic pain and further validate EEG theta power as a reliable ‘biosignature’ of spontaneous pain.