bluuebunny/crossref_metadata_2025_split huggingface dataset:
The utility or lack thereof regarding serum p53 antibody for detecting ulcerative colitis-associated colorectal cancer in the era of immunosuppressive therapy.
Authors: Toritani Kenichiro , Kimura Hideaki , Kunisaki Reiko , Watanabe Jun , Kunisaki Chikara , Ishibe Atsushi , Chiba Sawako , Inayama Yoshiaki , Endo Itaru 
Published: September 2019

Abstract
Background: Serum anti-p53 antibodies (Abs) have been considered useful for the early detection of ulcerative colitis-associated colorectal cancer (CAC). However, since the spread of immunosuppressive therapy for ulcerative colitis (UC) treatment in the 2010s, we have experienced a low prevalence of anti-p53 Abs in UC patients. The present study thus examined the utility of serum p53 Abs for detecting CAC in the era of immunosuppressive therapy.

Methods: A series of 320 consecutive surgical cases of UC patients between April 2008 and March 2019 were enrolled in this study. Patients with no serum anti-p53 Abs data were excluded. Of the 250 patients analyzed, 219 had no carcinoma or dysplasia (Group non-CAC), and 31 had carcinoma or dysplasia (Group CAC). Serum anti-p53 Abs were detected with an enzyme-linked immunosorbent assay. Immnohistochemical detection was performed in Group CAC. Immunosuppressive therapy included a history of medication with prednisolone >20 mg/day, immunosuppressant drugs, immunomodulator drugs or biologic therapies for UC.

Results: Immunosuppressive therapy was performed in 98.1% of Group non-CAC and 80.6% of Group CAC. There were no marked differences in serum anti-p53 Abs positivity between Groups non-CAC and CAC (8.7% vs. 3.2%, p =0.30). p53 staining positivity was noted in 90.3% of Group CAC, and the rate of serum p53 positivity was significantly lower in patients with immunosuppressive therapy than in those without in Group CAC (0.0% vs. 16.7%, p =0.04).

Conclusions: The utility of serum p53 Abs for detecting CAC is dubious in the era of immunosuppressive therapy.
Proposal of the ‘extreme rank plot’ for extreme value analysis: with an emphasis on flood frequency studies
Authors: Hammond Anthony 
Published: September 2019

AbstractTo assess model ‘fit’ for flood frequency studies, the annual maximum flow sample is often plotted alongside the frequency curve in an extreme value plot. The comparison is ill advised because a value is speculatively assigned for each rank, in the form of a frequency (the plotting positions); in which case a model of the frequencies is being used to assess a frequency model. The modelled and observed, with attributed plotting positions, are incommensurable. The proposed method in this paper does not attempt to provide a frequency attributed to the ranks and instead attributes ranks to the model under investigation. If the model is used to simulate thousands of samples of the same size as the observed, a distribution of possible peak flow values for each rank can be obtained. For each simulated sample, descriptive statistics can be derived. In this way, statistical testing can be undertaken to compare the observed with the modelled. Using such methods, two or more models can also be compared. Examples are provided for Flood Estimation Handbook pooling and continuous simulation models along with a comparison of the two.
A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles via a Key Intermediate of ortho-Ethoxyvinyl Nitroaryls by Domino Rearrangement and Their Anti- Inflammatory Activity
Authors: Nagaraju Bashetti , Shanmukhakumar Jagarlapudi V. , Seelam Nareshvarma , Subbaiah Tondepu , Prasanna Bethanamudi 
Published: September 2019

Background:
Recently, there has been a lot of scientific interest in exploring the syntheses of
oxygen and nitrogen-containing heterocyclic compounds due to their pharmacological activities. In addition,
benzisoxazoles play a very important role in organic synthesis as key intermediates.

Objective:
In this paper, we focused on developing a novel synthetic route for biologically active
arylisoxazoles under normal conditions, and simplified it to get high purities and yields, and also reported their
anti-inflammatory activities.

Method:
An efficient and simple method has been explored for the synthesis of novel 3-methyl arylisoxazoles
from o-nitroaryl halides via o-ethoxyvinylnitroaryls, using dihydrated stannous chloride (SnCl2.2H2O) in
MeOH / EtOAc (1:1) via Domino rearrangement in one pot synthesis.

Result:
We synthesized novel 3-methylarylisoxazoles from o-nitroarylhalides via o-ethoxyvinylnitroaryls,
using dihydrated stannous chloride (SnCl2.2H2O) in MeOH / EtOAc (1:1) via domino rearrangement. In this
reduction, nitro group and ethoxy vinyl group change to the functional acyl ketones, followed by hetero
cyclization. Here, the reaction proceeds without the isolation of intermediates like 2-acylnitroarenes and 2-
acylanilines. All the synthesized compounds were completely characterized by the NMR and mass spectra. The
compounds were also explored for their anti-inflammatory activity by carrageenan-induced inflammation in the
albino rats (150-200 g) of either sex used in this entire study with the use of Diclofenac sodium as the standard
drug. The initial evaluations identified leading targets with good to moderate anti-inflammatory activity.

Conclusion:
A simple, one-pot and convenient method has been explored for the synthesis of novel 3-
methylarylisoxazoles with high purity and reaction yields. All the compounds 3a, 3c, 3d, 3f, 3g and 3h
exhibited 51-64% anti-inflammatory activities.
A Baby Formula Designed for Chinese Babies: Content Analysis of Milk Formula Advertisements on Chinese Parenting Apps
Authors: Zhao Jing , Li Mu , Freeman Becky 
Published: September 2019

Background
China is the largest market for infant formula. With the increasing use of smartphones, apps have become the latest tool used to promote milk formula. Formula manufacturers and distributors both have seized the popularity of apps as an avenue for marketing.

Objective
This study aimed to identify and analyze milk formula ads featured on Chinese pregnancy and parenting apps, to build the first complete picture of app-based milk formula marketing techniques being used by milk formula brand variants on these apps, and to more fully understand the ad content that potentially undermines public health messaging about infant and young child feeding.

Methods
We searched for free-to-download Chinese parenting apps in the 360 App Store, the biggest Android app store in China. The final sample consisted of 353 unique formula ads from the 79 apps that met the inclusion criteria. We developed a content analysis coding tool for categorizing the marketing techniques used in ads, which included a total of 22 coding options developed across 4 categories: emotional imagery, marketing elements, claims, and advertising disclosure.

Results
The 353 milk formula ads were distributed across 31 companies, 44 brands, and 79 brand variants. Overall, 15 of 31 corporations were international with the remaining 16 being Chinese owned. An image of a natural pasture was the most commonly used emotional image among the brand variants (16/79). All variants included branding elements, and 75 variants linked directly to e-shops. Special price promotions were promoted by nearly half (n=39) of all variants. A total of 5 variants included a celebrity endorsement in their advertising. A total of 25 of the 79 variants made a product quality claim. Only 14 variants made a direct advertisement disclosure.

Conclusions
The purpose of marketing messages is to widen the use of formula and normalize formula as an appropriate food for all infants and young children, rather than as a specialized food for those unable to breastfeed. Policy makers should take steps to establish an appropriate regulatory framework and provide detailed monitoring and enforcement to ensure that milk formula marketing practices do not undermine breastfeeding norms and behaviors.
Evaluation of Nurses’ Performance Regarding Personal Protective Equipment at Rania Teaching Hospital
Authors: Omar Sharif Bayan , M. Khdir Frishta , M. Khdir Padasht , A. Rasul Sarezh 
Published: September 2019

Personal protective equipment (PPE) refers to protective clothing that acts as a barrier between infectious materials such as viral, bacterial contaminants and the skin, mouth, nose, eyes and mucous membranes. It includes gloves, mask, eye goggles and gown. It is a shortage of study of university students. The aim of the current study was performing to provide demographic data and to evaluate nurse’s performance regarding PPE at Rania teaching Hospital in Kurdistan region of Iraq, during the period of 10th October up to 7th of March. A non- probability purposive sample of (72 nurses), data collection of the study instrument was constructed of total (42) items. A professional team that contains of (11) experts were performed validity of the instrument. Reliability of the instrument was determined through the use of Equivalence (inter-rator or inter-observer), the data were collected through the use of evaluation technique then organized and coded into computer files. Statistical approaches were uses for data analyzed, also data analysis by (SPSS version 25). The result has revealed that highest age of the sample was between 30-39 years and most of them were institute nurses and more than half of nurses had less than 10 years of employment but most of them not trained yet. The majority of nurses were performed many nursing procedures such as wound dressing, suturing, suctioning, naso-gastric tube and Foley catheter insertion without using PPE properly and without washing hands before procedures. Also, there was no significant relationship between personal protective equipment and some socio- demographic data. The researchers recommended training course regarding personal protective equipment by the ministry of health/infection control department and participants of symposia.
Detection of Humoral and Cellular Immune Responses in Buffaloes Naturally Infected with Sarcocystosis with Risk Factor Assessment
Authors: El Shanawany Eman E. , Nassar Somia A. , Beshir Ata Emad 
Published: September 2019

Abstract
Sarcocystosis is a silent, parasitic disease which affects various animal species and causes significant economic losses. It is caused by a number of different intracellular Sarcocystis spp. This study was aimed to detect the host humoral and cellular immune response due to natural infection. Adding to the determination of the infection rate in Monufia Governorate, Egypt. A total number of 127 Egyptian buffaloes (Bubalus bubalis); 30 males and 97 females between 2-11 years of age were examined during 2018. An infection rate of 74% (94/127) was detected by macroscopic examination. The old age females were found to be at a high risk of 90.7% (88/97) in comparison with the young males 20% (6/30). Immunologically, the cellular and humoral immune response was determined using ELISA. A marked down-regulation of the proinflammatory Th-1 cytokine (IFN-γ) and up-regulation of the anti-inflammatory Th-2 cytokine (IL-5) adding to a high level of IgG and IgE were detected in the infected animals compared to the non infected ones. The local cellular immune response in the infected tissues was characterized by an accumulation of mixed inflammatory cells, granuloma formation, eosinophilic infiltration, muscular edema, and necrotic degeneration. In conclusion, the Sarcocystis infection rate in the naturally infected buffaloes in Monufia Governorate was high. This is the first study to provide a fundamental insight into the immune profile in buffaloes infected with Sarcocystis spp. So, it will provide valuable insights to develop novel effective vaccines in future studies. Moreover, sensitive and specific tools should be established for the accurate diagnosis of this disease in the different Egyptian governorates through well-structured serological surveys.
Manipulating Titles in Translation
Authors: Darwish Ibrahim , Sayaheen Bilal 
Published: September 2019

Abstract
This study investigates the ways in which book titles are manipulated when translated from English into Arabic. One hundred English book titles from various genres whose Arabic translations are manipulated are meticulously studied and analysed against Viezzi’s (2013) model of manipulating translated book titles. The findings show that although Viezzi’s model fits literary works and movies better, it can be useful in analysing the translated titles of different books coming from various genres. Statistically, the findings reveal the following descending order of the most manipulated aspects of English-Arabic translated titles: being more/less explicit (35%), offering different keys to the interpretation of the text (20%), adding/removing genre information (15%), presenting different viewpoints (10%), seducing the target readers (8%), highlighting different characters’ aspects (5%), adding/removing names of characters (3%), adding/removing allusions to other works (3%) and suggesting/removing moral lessons (1%). It is argued that no matter what aspects of translated titles are manipulated, the whole process is done to attract the potential readers in the target market and this involves multiple players, such as translators, editors and publishers.
Strengthening the Students Nationalism in Border Areas
Authors: Zakso Amrazi , Agung Iskandar , Widiputera Ferdi 
Published: September 2019

Abstract
This study aims to determine the condition of student nationalism in the border area, as well as the role of a number of parties that influence its formation. The results are suggested to draw conclusions on how to increase student nationalism. We find that the nationalism conditions of students in the border area resulted in a moderate performance, and susceptible to be influenced by various stimuli, both from within the country and neighboring countries. The evidence presented in this analysis points to the fact that these stimuli often weaken nationalist awareness and attitude, both related to ideology, constitution, unity, diversity and sovereignty of the nation and state. The results suggest that further action required to increase student nationalism in a short, medium- and long-term efforts as to prevent external influences, especially crimes in the border areas. The role of several parties need to be improved, namely families, schools and youth organizations in the vicinity as well as government support in the form of funding, activity facilities, instructors, training, and others. Especially the role of schools, it is necessary to involve active students in the implementation of strengthening nationalism through a problem-solving approach.
Systematics and faunistics of Neotropical Euliina, 2: Direconta gen. n.
Authors: Razowski Józef , Becker Vitor O. 
Published: September 2019

Abstract
The new euliine genus Direconta and its five new Brazilian species (D. gnesia sp. n., D. recondita sp. n., D. barrasiana sp. n., D. curitibana sp. n., and D. lentigana sp. n.) are described and illustrated.
Muscle Fibre Types and Their Relation to Meat Quality Traits in Pigs
Authors: Lebedová N. , Stupka R. , Čítek J. , Zadinová K. , Kudrnáčová E. , Okrouhlá M. , Dundáčková P. 
Published: September 2019

Abstract
The authors have been studying various characteristics of muscle fibres and their relationship to the meat quality parameters for many years. However, the conclusions drawn by researchers often differ. A higher proportion of glycolytic IIB fibres in pig muscles is usually related to paler meat with lower water holding capacity. On the other hand the relationship between muscle fibres and meat texture parameters is not clear. Studies using immunohistochemistry methods that allow a more detailed classification of individual muscle fibre types could bring new findings in this area. It would thus be possible to influence muscle fibre type composition in the muscle to achieve the desired meat quality using various extrinsic and intrinsic factors. The main aim of this review is to summarise current knowledge on the description of muscle fibres typology and the effect of their morphological traits on pork meat quality.
Sharing College Knowledge
Authors: Johnson Jennifer Adrienne , Duncan Mary Katherine 
Published: September 2019

While undergraduate enrollment is increasing among historically underrepresented students, completion rates remain lower than their peers. A lack of college knowledge may be partly responsible. We used Gardner, Csikszentmihalyi, and Damon’s (2001) Good Work model to develop 2 programs to introduce historically underrepresented students to the expectations of college, that is, to improve their college knowledge. Assessment data (n = 44 in Program 1; n = 50 in Program 2) showed that while the programs were only somewhat effective at improving students’ understanding of what it means to do academic good work, students valued participating in the program.
Authors’ Note
We would like to thank Ms. Elizabeth G. Lucas and Dr. Joan F. Miller, Professor Emeritus, Department of Nursing, Bloomsburg University of Pennsylvania for their support of our university’s Good Work Initiative. We also thank the General Psychology Teaching Assistants, as well as the faculty and staff of Bloomsburg University of Pennsylvania who volunteered to help implement the Good Work reflective sessions. In addition, we extend our gratitude to Dr. Irvin Wright and Dr. Kristin Austin of the ACT101/Educational Opportunity Program for their support. Finally, we are indebted to Dr. Howard Gardner and his colleagues at Project Zero, including Wendy Fischman, Lynn Barendsen, Margot Locker, Paromita De, and Daniel Mucinskas for their thoughtful consultation and encouragement.
Üç hücreli motif genelleme ile oluşturulan küçük ölçekli biyolojik sinir ağlarının bellek davranışı
Authors: TURAN Ahmet , KAYIKÇIOĞLU Temel 
Published: September 2019

Biyolojik bellek yapısını ve fonksiyonlarını anlamak için teorik ve deneysel pek çok çalışma yapılmaktadır. Bu çalışmalarda biyolojik ağların, özel hücreler arası bağlantılardan (motifler) oluştuğu görülmüştür. Deneysel çalışmalar ışığında oluşturulan modeller üzerinde, biyolojik ağlardan oluşan bellek yapıları ve bu yapıların temel yapı taşı olan motifler incelenmektedir. Çalışmamızda sinir hücresi, sadece soma bölümünden oluşan ve tek bölmeli hücre şeklinde modellendi. Hücreler arası iletişim kimyasal sinaps şeklinde tercih edildi ve modelde hücreler arası iletişim incelendi. Hücre rolleri giriş, ara ve çıkış olarak düşünülen üç hücreli motiflerde, uzun -ve kısa dönem bellek davranışı çalışıldı. Üç hücreli motiflerin giriş, ara ve çıkış hücrelerinin çoklanması yöntemiyle oluşturulan (motif genelleme) küçük ölçekli biyolojik ağların, uzun -ve kısa dönem bellek davranışları tespit edildi. Motiflerde ve motiflerden oluşan ağlarda yaptığımız çalışmalardan elde edilen bulgular karşılaştırıldı. Biyolojik ağın, kendisini oluşturan motiflerle aynı bellek davranışını sergilediği gösterildi. Böylece biyolojik ağların bellek davranışlarını anlayabilmek için öncelikle ağda bulunan motifler üzerinde daha detaylı çalışılması gerektiği ortaya konuldu.
Pengaruh Karakteristik Internal Perusahaan terhadap Kinerja Perusahaan Sektor Barang KonsumsiPengaruh Karakteristik Internal Perusahaan terhadap Kinerja Perusahaan Sektor Barang Konsumsi
Authors: Hartini Hartini , Rahayu Dwi Hartini 
Published: September 2019

Penelitian ini bertujuan untuk menguji pengaruh karakteristik internal perusahaan terhadap kinerja perusahaan pada sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia. Variabel dependen dalam penelitian ini adalah kinerja perusahaan yang diukur dengan return on asset, sedangkan variabel independen yang digunakan adalah umur perusahaan, ukuran perusahaan, pertumbuhan penjualan, likuiditas dan rasio hutang. Metode penelitian menggunakan analisis regresi berganda untuk data panel. Sampel yang digunakan dalam penelitian ini meliputi 27 perusahaan yang bergerak di sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia selama tahun 2013-2017. Hasil penelitian ini menunjukkan bahwa umur perusahaan dan rasio hutang memiliki pengaruh negatif terhadap return on asset dan pertumbuhan perusahaan berpengaruh positif terhadap kinerja.Perusahaan yang telah lama berdiri harus dapat melakukan inovasi produk dan meningkatkan volume penjualan serta berhati-hati dalam menggunakan hutangnya demi kelangsungan hidup perusahaan. Kata kunci: likuiditas, pertumbuhan penjualan, leverage, ROA, ukuran perusahaan, umur perusahaan
Gorgonian octocoral community at Varadero coral reef in the Colombian Caribbean: diversity and spatial distribution
Authors: Manrique Rodríguez Nelson , Agudelo Claudia , Sanjuan-Muñoz Adolfo 
Published: September 2019

Varadero reef has unique ecological characteristics and faces the risk of disappearing because of the dredging for an access channel of large vessels to the Cartagena port in Colombia. In this ecosystem, the sessile benthic community, such as gorgonian octocorals and associated fauna, will be impacted. We examined the diversity and spatial distribution of gorgonians from seven sites located in the mixed coral reef zone. These organisms are generally found in depths between 6 and 10 m in the area. The richness of the gorgoniansspecies is lower than that recorded in other areas of the Caribbean. The low values of abundance and richness species are due to the characteristics of reef setoff and sedimentation processes existing in Cartagena bay.
Revision and update of the checklist of copepods (Crustacea: Hexanauplia) of the Colombian Caribbean
Authors: Gaviria Santiago , Dorado-Roncancio John , Ahrens Michael J. 
Published: September 2019

The aim of the study was to obtain a revised and updated checklist of the species of copepods of the Colombian Caribbean. Methods for updating included a critical compilation of records in published and unpublished articles, and our own results of a study of zooplankton in a project on bioinvasions of coastal waters, conducted in 2010. Twenty taxa reported solely in undergraduate thesisneed taxonomical comprobation and were excluded from the inventory. As a baseline, we used the most recent inventory published by Medellín-Mora and Navas (2010). Ten species recorded in the already mentioned project are new records. Thirteen species reported by other researchers in publications after 2010 increased the species list. The inventory totals 214 species of copepods (158 Calanoida, 38Cyclopoida, 15 Harpacticoida, 2 Mormonilloida and 1 Monstrilloida). Most species are planktonic (201), while only a few are benthic (10) or epibenthic (3). Nomenclature of the taxa was revised and updated as well. The highest copepod diversity corresponds to the ecoregion Colombian Oceanic (127 species), followed by Tayrona (94), Magdalena (82) and Morrosquillo (78). The lowest number corresponds to San Andrés and Providencia Archipelago (49). The limited information existing about benthic and parasitic copepods warrants an increment on the study these groups. Most of them belong to orders Harpacticoida and Siphonostomatoida.
Passado presente : estudo exploratório sobre a utilização turística do patrimônio arqueológico no Estado do Rio de Janeiro
Authors: Oliveira Maria Amália Silva Alves de 
Published: September 2019

São João Marcos é um sítio arqueológico formado pelas ruínas da cidade de mesmo nome e cuja destruição, para dar lugar a construção de uma usina hidrelétrica, promoveu processo de desocupação para posterior inundação das terras; episódio que fomentou uma memória coletiva da destruição. No presente trabalho analisa-se a experiência de implantação e funcionamento de um Parque Arqueológico erguido sobre aquelas ruínas objetivando verificar pontos positivos com vistas ao aproveitamento turístico de outros espaços em ruínas existentes no estado do Rio de Janeiro, estado que devido sua trajetória histórica e social guarda vários vestígios, em forma de ruínas, deste passado. Encerra-se argumentando que desenvolvimento local ocorre efetivamente através de iniciativas que primeiramente atendam aos residentes.