bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in the Anopheles gambiae Complex
Authors: Love R Rebecca , Redmond Seth N , Pombi Marco , Caputo Beniamino , Petrarca Vincenzo , della Torre Alessandra ,   The Anopheles gambiae 1000 Genomes Consortium, Besansky Nora J 
Published: August 2019

Abstract
Chromosomal inversion polymorphisms play an important role in adaptation to environmental heterogeneities. For mosquito species in the Anopheles gambiae complex that are significant vectors of human malaria, paracentric inversion polymorphisms are abundant and are associated with ecologically and epidemiologically important phenotypes. Improved understanding of these traits relies on determining mosquito karyotype, which currently depends upon laborious cytogenetic methods whose application is limited both by the requirement for specialized expertise and for properly preserved adult females at specific gonotrophic stages. To overcome this limitation, we developed sets of tag single nucleotide polymorphisms (SNPs) inside inversions whose biallelic genotype is strongly correlated with inversion genotype. We leveraged 1,347 fully sequenced An. gambiae and Anopheles coluzzii genomes in the Ag1000G database of natural variation. Beginning with principal components analysis (PCA) of population samples, applied to windows of the genome containing individual chromosomal rearrangements, we classified samples into three inversion genotypes, distinguishing homozygous inverted and homozygous uninverted groups by inclusion of the small subset of specimens in Ag1000G that are associated with cytogenetic metadata. We then assessed the correlation between candidate tag SNP genotypes and PCA-based inversion genotypes in our training sets, selecting those candidates with &gt;80% agreement. Our initial tests both in held-back validation samples from Ag1000G and in data independent of Ag1000G suggest that when used for in silico inversion genotyping of sequenced mosquitoes, these tags perform better than traditional cytogenetics, even for specimens where only a small subset of the tag SNPs can be successfully ascertained.
Saccharomyces cerevisiae Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding
Authors: Chen Chi-Fu , Pohl Thomas J , Chan Angela , Slocum Joshua S , Zakian Virginia A 
Published: August 2019

Abstract
Two common features of centromeres are their transcription into noncoding centromere RNAs (cen-RNAs) and their assembly into nucleosomes that contain a centromere-specific histone H3 (cenH3). Here, we show that Saccharomyces cerevisiae cen-RNA was present in low amounts in wild-type (WT) cells, and that its appearance was tightly cell cycle-regulated, appearing and disappearing in a narrow window in S phase after centromere replication. In cells lacking Cbf1, a centromere-binding protein, cen-RNA was 5–12 times more abundant throughout the cell cycle. In WT cells, cen-RNA appearance occurred at the same time as loss of Cbf1’s centromere binding, arguing that the physical presence of Cbf1 inhibits cen-RNA production. Binding of the Pif1 DNA helicase, which happens in mid–late S phase, occurred at about the same time as Cbf1 loss from the centromere, suggesting that Pif1 may facilitate this loss by its known ability to displace proteins from DNA. Cen-RNAs were more abundant in rnh1Δ cells but only in mid–late S phase. However, fork pausing at centromeres was not elevated in rnh1Δ cells but rather was due to centromere-binding proteins, including Cbf1. Strains with increased cen-RNA lost centromere plasmids at elevated rates. In cbf1Δ cells, where both the levels and the cell cycle-regulated appearance of cen-RNA were disrupted, the timing and levels of cenH3 centromere binding were perturbed. Thus, cen-RNAs are highly regulated, and disruption of this regulation correlates with changes in centromere structure and function.
Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3-Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors withRAS/RAFAlterations
Authors: Bardia Aditya , Gounder Mrinal , Rodon Jordi , Janku Filip , Lolkema Martijn P. , Stephenson Joe J. , Bedard Philippe L. , Schuler Martin , Sessa Cristiana , LoRusso Patricia , Thomas Michael , Maacke Heiko , Evans Helen , Sun Yongjian , Tan Daniel S.W. 
Published: August 2019

AbstractBackgroundThis multicenter, open-label, phase Ib study investigated the safety and efficacy of binimetinib (MEK inhibitor) in combination with buparlisib (phosphatidylinositol 3-kinase [PI3K] inhibitor) in patients with advanced solid tumors with RAS/RAF alterations.Materials and MethodsEighty-nine patients were enrolled in the study. Eligible patients had advanced solid tumors with disease progression after standard therapy and/or for which no standard therapy existed. Evaluable disease was mandatory, per RECIST version 1.1 and Eastern Cooperative Oncology Group performance status 0-2. Binimetinib and buparlisib combinations were explored in patients with KRAS-, NRAS-, or BRAF-mutant advanced solid tumors until the maximum tolerated dose and recommended phase II dose (RP2D) were defined. The expansion phase comprised patients with epidermal growth factor receptor (EGFR)-mutant, advanced non-small cell lung cancer, after progression on an EGFR inhibitor; advanced RAS- or BRAF-mutant ovarian cancer; or advanced non-small cell lung cancer with KRAS mutation.ResultsAt data cutoff, 32/89 patients discontinued treatment because of adverse events. RP2D for continuous dosing was buparlisib 80 mg once daily/binimetinib 45 mg twice daily. The toxicity profile of the combination resulted in a lower dose intensity than anticipated. Six (12.0%) patients with RAS/BRAF-mutant ovarian cancer achieved a partial response. Pharmacokinetics of binimetinib were not altered by buparlisib. Pharmacodynamic analyses revealed downregulation of pERK and pS6 in tumor biopsies.ConclusionAlthough dual inhibition of MEK and the PI3K pathways showed promising activity in RAS/BRAF ovarian cancer, continuous dosing resulted in intolerable toxicities beyond the dose-limiting toxicity monitoring period. Alternative schedules such as pulsatile dosing may be advantageous when combining therapies.
DEVELOPMENT OF EXPERIMENTAL POWER REACTOR (EPR) MODEL FOR SAFETY ANALYSES USING RELAP5
Authors: Ekariansyah Andi Sofrany , Subekti Muhammad , Widodo Surip , Tjahjono Hendro , Susyadi Susyadi , Wahyono Puradwi Ismu , Budianto Anwar 
Published: August 2019

Pebble bed reactor design, classified as the high temperature gas-cooled reactor (HTGR), is currently being part of BATAN main program to promote nuclear energy by starting the Experimental Power Reactor (EPR) program since 2015. Starting from 2018, the detail design document has to be submitted into nuclear regulatory body for further assessment. Therefore results of design analysis have to be supplemented by performing a design evaluation, which can be achieved by developing the model of the EPR. The development is performed using RELAP5/SCDAP/Mod.3.4 as the thermal-hydraulic analysis code validated for the light-water reactor having module for the pebble fuel element and non-condensable helium gas. Methodology of model development consists of defining the helium flow path inside the reactor pressure vessel, modelling of pebble bed core including its power distribution, and modelling of reflector components to be simulated under 100 % core power. The developed EPR model results in design parameters, which confirm the main thermal data of the EPR, including the pebble and reflector temperatures. The peak pebble temperature is calculated to be 1,375 °C, which requires further investigations in the model accuracy, since the reference values are around 1,015 °C, even it is below the pebble temperature limit. For safety analysis, the EPR model can be used under nominal core flow condition, which produces more conservative results by paying attention on the RELAP5 specific modules for the pebble bed-gas cooled system.Keywords: experimental power reactor, development, RELAP5, steady-state
Assessment of postoperative relief and complications correlated with septoplasty and septoplasty with turbinectomy
Authors: Rawat Sharad , Mahajan G. D. , Sonar Tejal , Rathod Ashwini 
Published: August 2019

<p class="abstract"><strong>Background:</strong> Nasal obstruction was the common symptom of deviated nasal symptom. Many surgical procedures are available to correct the deviation. The current study was aimed to assess and compare the postoperative relief and complications of septoplasty alone and septoplasty with turbinectomy.</p><p class="abstract"><strong>Methods:</strong> This prospective study was done on 50 patients with nasal blockage due to deviated nasal septum. Study was done at department of ENT, Dr. D.Y. Patil Medical College and Hospital, DPU between July 2016 to September 2018. Patients randomly selected and operated with septoplasty alone (n=25) and septoplasty with turbinectomy (n=25). Assessment and comparisons was made in terms of postoperative relief and complications in both the groups. </p><p class="abstract"><strong>Results:</strong> Significant postoperative relief was seen in group of patients after septoplasty with turbinectomy. Retained deviation and dryness of nose are the common complications observed in group of patients treated with septoplasty and septoplasty with turbinectomy respectively and on follow up of 4 weeks postoperatively the rate of frequency of complications was reduced in group of patients managed with septoplasty with turbinectomy.</p><p class="abstract"><strong>Conclusions:</strong> Postoperative relief and reduction in complication rate after 4 week follow-up was higher in group of patients operated with septoplasty with turbinectomy compared to group of patients managed with septoplasty alone.</p>
Evaluación de las características físicas y sensoriales de licor de cacao asociadas a modelos de siembra
Authors: Moreno-Martínez Edith , Gavanzo-Cárdenas Óscar Mauricio , Rangel-Silva Fabian Alberto 
Published: August 2019

El fomento de cultivos comerciales de cacao ha conllevado el aumento del uso de modelos de siembra, ha favorecido la organización genética y la estandarización del proceso de fermentación, y ha optimizado la calidad, según las necesidades del mercado y del consumidor. Teniendo en cuenta esto, se realizó la evaluación física y sensorial de cuatro modelos de siembra en dos municipios: Arauquita, del departamento de Arauca, y San Vicente de Chucurí, del departamento de Santander. Los modelos evaluados fueron los siguientes: Modelo 1 (M1), autocompatibles: FSV41, FTA2, FEAR5; Modelo 2 (M2), tamaño de grano: FSA12, FSA13, FLE3, FLE2; Modelo 3 (M3) tolerancia monilia: CCN51, FEC2, CAU39; Modelo 4 (M4) monoclonal: CCN51. La evaluación física y sensorial se llevó a cabo por el panel de catación, donde se analizaron: humedad (%), índice de grano (I.G), fermentación (%); y para el licor de cacao se describieron las características sensoriales de sabores básicos: cacao, acidez, amargor, astringencia; específicos: fruta fresca, fruta seca, floral, nuez, dulce y otros. Se hizo la prueba no paramétrica de Wilcoxon, para determinar si existían diferencias significativas entre cada una de las variables de los modelos evaluados. Adicionalmente se hizo un análisis de componentes principales (ACP) para evaluar la relación entre las variables evaluadas y las características de los modelos. Según los resultados, el índice de grano más alto fue dado al M1. Sensorialmente, el M1 se caracterizó por tener altos valores en sabor cacao, fruta fresca, fruta seca, nuez y dulce. El M4 se destacó por altas intensidades de acidez, amargor y sensación de astringencia. La calidad física y sensorial de los modelos de siembra en las dos localidades no presentó diferencias significativas.
Model Pemberdayaan Ekonomi Dengan Filantropi Islam Dalam Mewujudkan Kesejahteraan Masyarakat
Authors: Syahril Syahril , Abdullah Wahyuddin , Syahruddin Syahruddin 
Published: August 2019

This study aims to: 1) describe the model of community empowerment BAZNAS Makassar, 2) to find out the effectiveness community empowerment model in BAZNAS Makassar, 3) to find the right model of economic community empowerment in BAZNAS Makassar. This study was used field research methods with qualitative methode, which were analyzed descriptively. This study found that the BAZNAS Makassar has programme called Makassar prosperous, in which there are three productive programs: Revolving Fund Assistances, Life Skill Training and ZCD (zakat community development). The prosperous Makassar program has not been maximized in implementing Islamic philanthropy, because of consumptive programs are still larger than productive programs. Regarding the effective empowerment model, BAZNAS Makassar can implement a model of economic empowerment program for coastal areas.[Penelitian ini bertujuan untuk: 1) mendeskripsikan model pemberdayaan masyarakat pada BAZNAS kota Makassar, 2) mengetahui efektifitas model pemberdayaan BAZNAS kota Makassar, 3) menemukan model pemberdayaan ekonomi yang tepat bagi BAZNAS kota Makassar. Studi ini dilakukan dengan menggunakan metode penelitian lapangan (field research) dengan metode kualitatif (qualitative method) yang dilakukan secara deskriptif analisis. Penelitian ini menemukan bahwa program pemberdayaan ekonomi BAZNAS kota Makassar disebut Makassar makmur, di dalamnya terdapat tiga program produktif yaitu Bantuan Dana Bergulir, Pelatihan Life Skill, dan ZCD (zakat community development). Program Makassar makmur belum maksimal dalam menerapkan filantropi Islam, karena program konsumtif masih lebih besar dari program produktif. Sedangkan untuk Model pemberdayaan yang efektif, BAZNAS kota Makassar dapat melaksanakan model program pemberdayaan ekonomi pesisir.]
BLENDED LEARNING: STUDI EFEKTIVITAS PENGEMBANGAN KONTEN E-LEARNING DI PERGURUAN TINGGI
Authors: Astuti Puji , Febrian Febrian 
Published: August 2019

Abstrak Tujuan penelitian ini adalah untuk mengkaji efektifitas pengembangan konten e-learning tipe blended learning sebagai respons pembelajaran 4.0 untuk online learning di Perguruan Tinggi. Integrasi online learning pada penelitian ini dilakukan dengan mengembangkan konten e-learning untuk mata kuliah Kapita Selekta Matematika berupa: bahan ajar, video pembelajaran, penugasan, forum diskusi, dan ujian online. Untuk mencapai tujuan tersebut, penelitian pengembangan ADDIE dilakukan pada subjek penelitian mahasiswa semester 2 tahun akademik 2017/2018 Program Studi Pendidikan Matematika. Data terdiri dari data hasil komentar dan saran ahli terhadap konten e-learning yang dikembangkan peneliti dan data hasil tes mahasiswa. Hasil penelitian menunjukkan bahwa konten e-learning efektif untuk mencapai tujuan pembelajaran pada subjek penelitian ini.

AbstractThis research examines the effectiveness of online learning type blended learning in higher education. The integration of online learning was conducted by developing e-learning content for the Mathematics Capita Selecta course in the form of: teaching material, learning video, online assignment, discussion forum, and online quiz. ADDIE development research model was carried out involving subject of the second semester students of Mathematics Education Study Program in 2018/2019 academic year. The data collected were comments and advices from the expert about the e-learning content and student test results. The results showed that e-learning content was effective in achieving learning objectives on the subject of this study.
Analisis Penayangan Film Kartun Anak-Anak di Televisi Swasta Nasional Indonesia dalam Memberikan Pesan Moral pada Anak-Anak
Authors: Nugrahaeni Elisabeth 
Published: August 2019

Abstract
This study describes the analysis of a cartoon showing children in national private television in providing moral knowledge. The research was conducted in three private television is RCTI, MNCTV, and SpacetoonTV. The research looked at the moral messages given through these cartoons. Most of television is already presenting cartoon movies that give a moral message. However, the results of this study indicate that Indonesia has not been presented on national television films in the country that gives a moral message in accordance with national culture.
Keywords: communication education, cartoon kids, the moral message
Representasi Sosial tentang Kiprah PKS di Panggung Politik Indonesia (Analisis wacana situs dikedaikopi.net)
Authors: Safitri Dini 
Published: August 2019

Abstract
This studyâ€™s objective is to discover social representations of political action performed by elite of PKS (Justice and Prosperous Party) during the party involvement in government, as viewed from its grassroots. Using texts and comments from dikedaikopi.net site, the study also intents at better understanding on how internet-based media is representing critic aimed at authority that was legitimated through religious doctrine. This study also intents to discover what is contained within the representation of wealth in Islamic view as well as its form. The study found that political praxis taken into account by PKS had created series of controversies. The controversies led into some debates within their ranks and grassroots, including on the issue of wealth. Up to now, those debates are controled using religious doctrine of maslahat daâ€™wah (what is favourable for Islamic calling)

Keywords :
Political Islam, PKS, social representations, internet
REALITAS MASYARAKAT INDONESIA DALAM MEDIA MASSA
Authors: Soegiarto Asep 
Published: August 2019

Abstract
The mass media, not just serve as the grantor information, the amusement and social control or fourth power as a nation ( the four estate ), but also as a form of public opinion who directs and public opinion in the issues developing world. Reporters when covering an event and writing it has a tendency to subjective and biased. The problem of bias in the press is not a matter of who, or of what system, is supported. The problem is that the bias exists, and the system through which our media operates seems guaranteed to ensure that bias will continue. Journalistic product in the media is not the whole of the reality of the society but only parts of reality that described as realities. In a so-called media image. The news media in a determined by its media ownership, and other factors it has a very significant role aside from bias a journalist

Key Word: Objectivity, Media Biased, Media Image
POLA KOMUNIKASI ANTAR PRIBADI DOSEN PENASEHAT AKADEMIK DAN MAHASISWA DALAM RANGKA MENGOPTIMALKAN PERAN DAN FUNGSI KEPENASEHATAN AKADEMIK
Authors: SARI WINA PUSPITA , SOEGIARTO ASEP 
Published: August 2019

Abstract
Students in a University have many problems that can impact the success of their study. In order to help students for searching solutions, they have a lecturer as a student counselor. But the process of counselling u student and student counselor sometimes not working, there are barriers between them. Interpersonal communication is communication between at least two people, face to face and there are openness, emphaty, positiveness, supportiveness and equality in effective interpersonal communication.This is a descriptive qualitative research, using depth interview to key informan and informan to collect data. The interpersonal communication between student counselor and student had been used, but only in academic problem. Students havenâ€™t believed their lecturer to talk about personal problem. According to that problem, counselors have to make their student comfortable to talk their personal problem.
Key word : Effective interpersonal communication, student counselor, student problem

Terkadang mahasiswa menemui banyak kendala dan beragam baik akademis maupun masalah pribadi yang dapat mengganggu proses belajar mahasiswa dan akan menentukan tercapai tidaknya hasil pengembangan potensi dan hasil belajar yang optimal. Oleh karena itu, diperlukanlah peran dosen penasehat akademik untuk memberikan bimbingan, motivasi serta nasehat yang bersifat akademik kepada mahasiswa. Dari sudut pandang ilmu komunikasi, agar proses kepenasehatan akademik berjalan sebagaimana mestinya maka diperlukan sebuah pola komunikasi yang efektif dan efisien antara dosen penasehat akademik dan mahasiswa. Penelitian ini menggunakan teori komunikasi antar pribadi yang efektif menurut ancangan humanistic dengan keterbukaan, empati, sikap positif, sikap mendukung dan kesetaraan. Metodologi yang digunakan adalah deskriptif kualitatif, dengan menentukan key informan dan informan sebelumnya. Teknik pengumpulan data menggunakan wawancara mendalam. Pola komunikasi antar pribadi dengan menggunakan ancangan humanistis belum dilaksanakan secara optimal, keterbukaan, empati, sikap mendukung, sikap positif dan kesetaraan pada dasarnya sudah dilakukan namun masih dalam tataran permasalahan akademis saja. Berdasarkan temuan tersebut penulis menyarankan agar komunikasi antar pribadi dilakukan lebih intensif, tidak hanya pada permasalahan akademis dan jemput bola perlu dilakukan oleh dosen PA terhadap mahasiswa.
Kata kunci : Pola Komunikasi Antar Pribadi yang Efektif, Dosen PA, Masalah mahasiswa
ANALISIS SWOT PRODI DIII HUMAS FIS UNJ
Authors: Safitri Dini 
Published: August 2019

Abstract
Prodi D3 Public Relations FIS UNJ standing since June 3, 2005, by Decree No.1846 / D / T2005. In the development of these courses has been developed into a favorite Prodi, but a number of studies need to be done to get accurate data that Prodi DIII FIS PR UNJ some of the authors are interested kelebihan.Untuk perform a SWOT analysis. The results showed that the S or the strength of the study program is to produce qualified graduates, have a qualified lecturer, low cost, study programs of public universities have a good name. W or weakness of the study program is accredited C and inadequate facilities. O or opportunities are expanding relations department of street vendors as graduates opportunities to work anyway. T or threat Prodi is a demand immediately improve lectures, use of introductory English, open S1, not to compete with PTN / PTS other more favorites.
Keywords: SWOT Analysis, Prodi DIII Public Relations UNJ

Abstrak
Terkadang mahasiswa menemui banyak kendala dan beragam baik akademis maupun masalah pribadi yang dapat mengganggu proses belajar mahasiswa dan akan menentukan tercapai tidaknya hasil pengembangan potensi dan hasil belajar yang optimal. Oleh karena itu, diperlukanlah peran dosen penasehat akademik untuk memberikan bimbingan, motivasi serta nasehat yang bersifat akademik kepada mahasiswa. Dari sudut pandang ilmu komunikasi, agar proses kepenasehatan akademik berjalan sebagaimana mestinya maka diperlukan sebuah pola komunikasi yang efektif dan efisien antara dosen penasehat akademik dan mahasiswa. Penelitian ini menggunakan teori komunikasi antar pribadi yang efektif menurut ancangan humanistic dengan keterbukaan, empati, sikap positif, sikap mendukung dan kesetaraan. Metodologi yang digunakan adalah deskriptif kualitatif, dengan menentukan key informan dan informan sebelumnya. Teknik pengumpulan data menggunakan wawancara mendalam. Pola komunikasi antar pribadi dengan menggunakan ancangan humanistis belum dilaksanakan secara optimal, keterbukaan, empati, sikap mendukung, sikap positif dan kesetaraan pada dasarnya sudah dilakukan namun masih dalam tataran permasalahan akademis saja. Berdasarkan temuan tersebut penulis menyarankan agar komunikasi antar pribadi dilakukan lebih intensif, tidak hanya pada permasalahan akademis dan jemput bola perlu dilakukan oleh dosen PA terhadap mahasiswa.
Kata kunci : Pola Komunikasi Antar Pribadi yang Efektif, Dosen PA, Masalah mahasiswa