bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gold-Based Nanoparticles Systems in Phototherapy - Current Strategies
Authors: Błaszkiewicz Paulina , Kotkowiak Michał 
Published: October 2018

Background:
The understanding of the action mechanism of the nanoparticles systems
consisting of metallic nanoparticles and dyes or cytostatic molecule is crucial for searching
and designing the ideal, novel drugs. In this review, we have considered moleculefunctionalized
metallic nanoparticle systems for phototherapy.

Methods:
We performed a thorough search of the high-quality peer-reviewed literature on
metallic nanoparticles systems in phototherapy, focusing on their biological importance and
the action mechanism.

Results:
138 papers were included in the mini-review. The majority of them discussed the
way of metallic nanoparticles functionalization and its impact on the biological activity of a
hybrid system.

Conclusion:
In this work, we show numerous medically and chemically important development
strategies of hybrid types of drugs which can be used in phototherapy. These systems
have a high affinity to the tumor cells surface proteins which transport the nanoparticles directly
into a cell. The application of functionalized metallic nanoparticles in phototherapy improved
photophysical properties lowered cytotoxicity of commonly used photosensitizers and
facilitated the development of the third generation photosensitizers. Furthermore, this type of
nanoparticles could also be used as a cytostatic drug carrier in the chemo or combined anticancer
therapies.
Virtual Screening, Molecular Dynamics and ADME-Tox Tools for Finding Potential Inhibitors of Phosphoglycerate Mutase 1 from Plasmodium falciparum
Authors: Ríos-Soto Lluvia , Avitia-Domínguez Claudia , Sierra-Campos Erick , Valdez-Solana Mónica , Cisneros-Martínez Jorge , Palacio-Gastellum Marcelo Gómez , Téllez-Valencia Alfredo 
Published: October 2018

Background:
Nowadays, malaria is still one of the most important and lethal diseases worldwide,
causing 445,000 deaths in a year. Due to the actual treatment resistance, there is an emergency to
find new drugs.

Objective:
The aim of this work was to find potential inhibitors of phosphoglycerate mutase 1 from P.
falciparum.

Results:
Through virtual screening of a chemical library of 15,123 small molecules, analyzed by two
programs, four potential inhibitors of phosphoglycerate mutase 1 from P. falciparum were found:
ZINC64219552, ZINC39095354, ZINC04593310, and ZINC04343691; their binding energies in SP
mode were -7.3, -7.41, -7.4, and -7.18 kcal/mol respectively. Molecular dynamic analysis revealed that
these molecules interact with residues important for enzyme catalysis and molecule ZINC04343691
provoked the highest structural changes. Physiochemical and toxicological profiles evaluation of these
inhibitors with ADME-Tox method suggested that they can be considered as potential drugs. Furthermore,
analysis of human PGAM-B suggested that these molecules could be selective for the parasitic
enzyme.

Conclusion:
The compounds reported here are the first selective potential inhibitors of phosphoglycerate
mutase 1 from P. falciparum, and can serve as a starting point in the search of a new chemotherapy
against malaria.
Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and study of Anticancer Activities
Authors: Spandana Zanjam , Sreenivasulu Reddymasu , MalathiRekha Tadigiri , Rao Mandava Venkata Basaveswara 
Published: October 2018

Background:In search of novel anticancer agents, a series of 1,3,4-oxadiazole derivatives (12a-j) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by 1HNMR, 13CNMR and ESI-MS spectral analysis.Methods:Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines, i.e. A549 (lung), MCF-7 (breast), A375 (melanoma) and HT-29 (colon).Results:Here, CA4 used as positive control. Among them, compounds 12b, 12c, 12f, 12g, 12h and 12j were exhibited promising activity than control drug.Conclusion:In conclusion, we have synthesized a novel series of 1,3,4-oxadiazole fused 1,3,4- thiazdiazole derivatives and their structures were confirmed by spectral analysis.
Bone Tunnel Placement Determination Method for 3D Images and Its Evaluation for Anterior Cruciate Ligament Reconstruction
Authors: Morita Kento , Nii Manabu , Koh Min-Sung , Kashiwa Kaori , Nakayama Hiroshi , Kambara Shunichiro , Yoshiya Shinichi , Kobashi Syoji 
Published: October 2018

Background:
Anterior cruciate ligament (ACL) injury causes knee instability which affects
sports activity involving cutting and twisting motions. The ACL reconstruction surgery replaces
the damaged ACL with artificial one which is fixed to the bone tunnels opened by the surgeon.
The outcome of the ACL reconstruction is strongly related to the placement of the bone tunnels,
therefore, the optimization of tunnel drilling technique is an important factor to obtain satisfactory
surgical results.

Aims:
The quadrant method is used for the post-operative evaluation of the ACL reconstruction
surgery, which evaluates the bone tunnel opening sites on the lateral 2D X-ray radiograph.

Methods:
For the purpose of applying the quadrant method to the pre-operative knee MRI, we have
synthesized the pseudo lateral 2D X-ray radiograph from the patients' knee MRI. This paper proposes
a computer-aided surgical planning system for the ACL reconstruction. The proposed system
estimates appropriate bone tunnel opening sites on the pseudo lateral 2D X-ray radiograph synthesized
from the pre-operative knee MRI.

Results:
In the experiment, the proposed method was applied to 98 subjects including subjects with
osteoarthritis. The experimental results showed that the proposed method can estimate the bone
tunnel opening sites accurately. The other experiment using 36 healthy patients showed that the
proposed method is robust to the knee shape deformation caused by disease.

Conclusion:
It is verified that the proposed method can be applied to subjects with osteoarthritis.
Comparison of the Effects of Metoprolol and Bisoprolol on Lipid and Glucose Profiles in Cardiovascular Patients
Authors: Almeman Ahmad Abdulrahman , Beshir Yasir Ahmed , Aldosary Ahmad Hamad 
Published: October 2018

Background:
Cardioselective beta-blockers may affect glucose or lipid profiles.

Objective:
We sought to compare the effects of two beta-blockers, metoprolol and bisoprolol, as the
most commonly used drugs in cardiology, on glucose and lipid profiles in patients with cardiovascular
diseases.

Methods:
We conducted a retrospective cross-sectional matched study at Prince Sultan Cardiac Center in
Burydah in August 2017. Patient records were screened, and adult patients with cardiovascular disorders
who were treated with a stable dose of metoprolol or bisoprolol were included. Parameters related to
glucose and lipid metabolism were compared using the Student’s t-test between the two groups.

Results and Conclusion:
The metoprolol and bisoprolol arms included 204 and 200 patients,
respectively.
Differential Effects of Doxazosin on Renin-Angiotensin-System- Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells
Authors: Ramírez-Expósito María Jesús , Martínez-Martos José Manuel 
Published: October 2018

Background:It has been described that doxazosin, an antihypertensive drug, also promotes glioblastoma cells death by inhibiting cell proliferation, arresting cell cycle and inducing apoptosis. Doxazosin has also demonstrated several modulator effects on renin-angiotensin system (RAS)- regulating aminopeptidase activities, which are highly involved in tumor growth in experimental glioma. Therefore, it remains to elucidate if the anti-tumoral effects of doxazosin could also be mediated by the proteolytic regulatory components of the RAS.Objective:To analyze the effects of doxazosin on cell growth and on RAS-regulating proteolytic regulatory aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase N (APN), aminopeptidase B (APB) and insulin-regulated aminopeptidase (IRAP) specific activities in the human neuroblastoma NB69 and astroglioma U373-MG tumoral cell lines.Methods:Human neuroblastoma NB69 and astroglioma U373-MG cell lines were treated with doxazosin 50-500 μM for 24h or 48h. The effects on cell growth and on RAS-regulating aminopeptidase specific activities were analyzed.Results:Doxazosin treatments promote a concentration-dependent inhibition on cell growth in both NB69 and U373-MG cells, being NB69 cells more sensitive to the drug than U373-MG cells. However, its effects on RAS-regulating aminopeptidase specific activities depend on the concentration used, the duration of the treatment and the cell type. These data confirm the existence of a different dynamic progression of RAS cascade in each tumoral cell line as a consequence of the treatment with doxazosin and time of action, which also implies a very dynamic metabolism of the peptides which participate in each step of RAS cascade.Conclusion:Our results indicate that doxazosin modifies the proteolytic regulatory enzymes of RAS cascade, modulating the bioactive efficacy of the different angiotensin peptides, and therefore, of their functional roles as initiators/promoters of cell proliferation as autocrine/paracrine mediators.
Predictors of Remission Maintenance after Etanercept Tapering or Withdrawal in Early Rheumatoid Arthritis: Results from the PRIZE Study
Authors: Emery Paul , Pedersen Ronald , Bukowski Jack , Marshall Lisa 
Published: October 2018

Objective:
To explore the influence of early treatment response to etanercept-methotrexate therapy on sustained remission after tapering/withdrawal of etanercept in methotrexate/biologic-naïve patients with early rheumatoid arthritis in the PRIZE study (ClinicalTrials.gov: NCT00913458).

Method:
In the initial 52-week open-label phase, enrolled patients received once-weekly etanercept 50 mg plus methotrexate. Patients who achieved DAS28 ≤3.2 at week 39 and <2.6 at week 52 were randomized to etanercept 25 mg plus methotrexate, methotrexate monotherapy, or placebo once weekly for 39 weeks in the double-blind phase. The relationships between responses in the open-label phase and sustained remission (DAS28 <2.6 at weeks 76 and 91, without glucocorticoid rescue therapy from weeks 52 to 64) in the double-blind phase were analyzed.

Results:
In the open-label phase, 70% of patients achieved DAS28 remission at week 52. In the double-blind phase, 63%, 40%, and 23% of patients had sustained DAS28 remission in the reduced-dose combination-therapy, methotrexate-monotherapy, and placebo groups, respectively. In patients receiving reduced-dose combination therapy, sustained remission was more likely in those who achieved DAS28 remission (p = 0.005) or low disease activity (p=0.044) in a shorter time, and who had a lower DAS28 (p = 0.016) or achieved ACR/EULAR Boolean remission (p < 0.05) at the end of the open-label phase. In patients receiving methotrexate monotherapy, sustained remission was associated with a lower acute-phase response (C-reactive protein, p = 0.007; erythrocyte sedimentation rate, p = 0.016) at the end of the open-label phase.

Conclusion:
Fast response and suppression of inflammation with etanercept-methotrexate therapy may predict successful etanercept tapering/withdrawal in patients with early rheumatoid arthritis.
Compensation after Distal Radial Fractures. A Review of 800 claims to the Norwegian System of Patient Injury Compensation 2000-2013
Authors: Clementsen Ståle , Hammer Ola-Lars , Engebretsen Erik , Jakobsen Rune , Randsborg Per-Henrik 
Published: October 2018

Background:
Distal radial fracture is the most common fracture in humans.

Objective:
The purpose of the present study was to assess the compensation claims filed to The Norwegian System of Patient Injury Compensation (NPE) after the treatment of distal radial fractures from 2000 through June 2013.

Methods:
Data received by the NPE were collected and categorized into groups depending on acceptance or rejection of the claim. In both groups, the cases were systemized according to the type of primary treatment, either operative or conservative. Patient demographics were recorded, along with the patient´s reason(s) for the compensation claim, registered complications and the NPE´s reason(s) for the acceptance or rejection of the claim.

Results:
Eight hundred compensation claims were received. Forty-three percent of claims were granted, of which 71% had been treated conservatively and 29% had received surgical treatment. Pain was the most common complaint. There were a higher number of upheld claims in hospitals with a population area of less than 100,000 people as opposed to larger hospitals.

Conclusion:
The most common cause for compensation was delayed intervention when reduction was lost after conservative treatment. Most of the compensations after surgery were due to wrong technique. Only 30 patients with upheld claims received volar plating. Pain is not a valid reason for compensation on its own. There is a higher risk of ending up with a complication that leads to compensation if the patient is treated in a small hospital.
Body Dysmorphic Disorder in Adolescents
Authors: Sharma Himanshu , Sharma Bharti , Patel Nisheet 
Published: October 2018

Background and Objectives:
Body Dysmorphic Disorder (BDD) is characterized
by an abnormal preoccupation with alleged misshapen body parts. There is often poor insight
and effort is made to hide the imagined defects, and consultation may be sought seeking
unnecessary cosmetic surgery or procedures. It is underdiagnosed and established treatment
protocols are lacking. The disease has a chronic and undulating course and is seriously
compromises quality of life. Despite the fact that the prime age of onset of BDD is during
adolescence relatively little has been written about it during this phase of life. This review
aims to comprehensively cover the present understanding of BDD, including clinical
features, epidemiology, psychopathology, nomenclature, comorbidity and management.

Methods:
A literature search was undertaken using suitable key words on Google Scholar,
MEDLINE & PsychoINFO up to June 2018 limited to articles in English.

Results:
he prevalence of BDD is variable in the general and psychiatric population with
equal gender distribution. Both sexes are equally affected. It is associated with poor
functioning and a chronic course. There is considerable comorbidity and diagnostic overlap
between BDD and obsessive-compulsive disorder, major depressive disorder, social anxiety
disorder, anorexia nervosa, schizophrenia spectrum disorders and personality disorders.
Psychiatric consultation is often late. Selective Serotonin Reuptake Inhibitors (SSRIs) and
Cognitive Behavior Therapy (CBT) are currently the first line modalities for treatment.
Internet based CBT, Acceptance and commitment therapy, and repetitive Transcranial
Magnetic Stimulation (rTMS) are emerging treatment options.

Conclusions:
BDD is a complex disorder with still lot of uncertainty about its diagnostic
placement, treatment approaches, especially for refractory patients, and prognosis. Further
study is needed to clarify its prevalence, especially in adolescents; to fully understand its
neurobiological aspects, to determine its exact relation to obsessive compulsive related
disorders, and to develop better treatment approaches.
Resource Mining for a Bioreactor Landfill
Authors: Meegoda Jay N. , Soliman Ameenah , Hettiaratchi Patrick A. , Agbakpe Michael 
Published: October 2018

Background: A new generation of the sustainable landfill is designed to achieve
sustainable Municipal Solid Waste (MSW) management. It is hybrid anaerobic/aerobic biodegradation
landfill followed by landfill mining. However, there is limited information on
landfill mining, especially the criteria and process for the practitioner to determine the end of
the landfill biodegradation to commence landfill mining.

Objective:
Hence the overall objective of this research was to develop a comprehensive resource
mining plan for bioreactor landfills.
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Method: When waste decomposition becomes slower or stopped, the landfill can be mined
to recover resources and utilize the recovered space. The amount of the gas generated, landfill
temperature and landfill settlement are indirect measures of landfill activity. Also, the
concentration of cellulose (C), hemicelluloses (H), and lignin (L) can describe the biodegradable
fractions of waste. Hence the biodegradation in landfills can be monitored by recording
the change in methane production, temperature, settlement and the (C+H)/L ratio of
waste. Once methane recovery is minimal, landfill reaches a maximum settlement and, ambient
temperature plus the (C+H)/L value reaches a stable value of 0.25 indicating end of
biodegradation. At this point landfill resources including compost material, non-recoverable
waste, and recyclables such as plastics, metal and glass can be mined and recovered. Compost
and recyclables can be sold at market value and the non-recovered waste with high energy
content can be used as refuse-derived fuel. Once the landfill has been mined space can
be reused thus eliminating the need to allocate valuable land for new landfills.
</P><P>
Result: The landfill mining detailed in this manuscript utilizes principles from single stream
type recycling facilities to ensure feasibility. The first landfill will be excavated and screened
to separate the biodegraded soil and compost fraction from the recyclables. Then the
screened recyclable materials are transported for further processing in a single stream type
separation facility where they will be separated, bundled and sold.

Conclusion:
A cost calculation was performed for the resource mining of Calgary Biocell
and if the mined resources are sold at market values, then the mining of Calgary Biocell
would generate approximately $4M.
A Spiral-Phase Rear Mounted Triple Masking for Secure Optical Image Encryption Based on Gyrator Transform
Authors: Khurana Mehak , Singh Hukum 
Published: October 2018

Background:
A spiral phase rear mounted masked scheme is proposed based on Gyrator
Transform (GT) to enhance the security contribution of second lens of the existing Double Random Phase
Encoding (DRPE) system by modulating the phase of the output obtained in output plane. An additional
third layer of Spiral Phase Mask (SPM) is included in the output plane in the same 4f system.

Objective:
To develop a symmetric cryptosystems to enhance the security potential of the second
lens and to prevent the comfortable realization of the cipher-image in the transform domain.

Methods:
The original image is first scrambled using Arnold transform with frequency and then is
convoluted with a secret random phase mask, RPM in GT and then obtained result is convoluted
with another secret RPM in inverse GT. The obtained result is then finally convoluted with SPM.

Results:
It verifies the sensitivity and achieves better performance in terms of recovering a high
quality image. Results show the security, performance and quality analysis on the basis of correlation
coefficient, occlusion attack, key sensitivity and noise attack, entropy and histogram.

Conclusion:
It enhances the security potential of second lens in DRPE and introduces diffusion in
the system. The system is simulated for binary and greyscale image and achieves better performance
as compared to existing DRPE variants. Key sensitivity is more secure and cannot recover original
image without knowing all the parameters. Correlation coefficient are also weakly correlated and
does not reveals relevant information. Simulation result demonstrates the feasibility and robustness
of cryptosystem.
Steal This Station: The Videofreex and Radical Banality of Pirate Broadcasting
Authors: Paulsen Kris 
Published: October 2018

In this review of the Here Come the Videofreex, the author questions Raskin and Nealon’s choice of a traditional chronological approach in their 2015 documentary on the Videofreex, and considers issues ranging to contemporary understandings of citizen journalism to the ubiquity of cameras in everyone’s back pocket. Paulsen asks questions about the importance of the Videofreex self-removal from mainstream media to rural New York and their relationship to other radical video collectives of the time.
Creative Data Mining Diamonds in Dystopia
Authors: Allison Jesse , Cellucci Vincent , Ostrenko Derek 
Published: October 2018

One of the most popular new media platforms for the proliferation and distribution of ideas related to Technology, Entertainment, and Design is produced in the form of TED Talks. For the independent TED event—designated by the x—TEDxLSU, three media artists developed a poetry performance web app, Diamonds in Dystopia, which applies advanced coding techniques to aggregate TED Talk transcripts as found text to generate new stanzas using a found text and Markov chains creative process, which enables succinct recombination of massive amounts of language as source material. This addition pushes the boundaries of the TED Talk by adding another exciting and popular form of new media, interactivity, to the mixture of mediums. Performance-scaled interactivity, specifically using mobile devices in an audience comprised of hundreds of users swaps the individualized information dissemination system and turns it into one capable of creative output or collaboration. The collaborative text contributed by the audience in Diamonds in Dystopia further engages information dissemination because the user’s interaction enables a parallel creative bond to form between the audience experience and the performing poet, in terms of the text methodology employed. By picking or clicking on the individual word selections of a seed poem that resonate with them, audience members create Markov chain reactions that creatively recombine and datamine a database of over 2,500 TED Talks to send a flurry of improvisational stanzas to the poet, which he then improvises into the poem on stage, creating and archiving an event-specific version of the poem and performance.
Ser Cubano (entrevista com Tania Bruguera)
Authors: Bruguera Tania , Goldberg Roselee 
Published: October 2018

Tania Bruguera nasceu em Havana, Cuba, em 1968, filha de Miguel Bruguera, conselheiro político cubano na Embaixada de Cuba em Paris e embaixador no Líbano e no Panamá, e de Argelia Fernandez, tradutora de espanhol-inglês com bacharelado em Ciências Sociais. Tania Bruguera estudou no Liceu Francês durante sua infância e, dos 12 anos em diante, em uma escola de arte em Havana, se graduando pelo Instituto Superior de Arte em 1992. Nos últimos sete anos [1998 a 2005], ela tem vivido em Chicago e em Havana, dividindo o ano entre duas cidades, duas culturas e duas ideologias, “entre passado e futuro”, como ela disse. Essas idas e vindas entre continente e ilha, intercaladas com extensas viagens internacionais, têm aguçado o entendimento de Bruguera sobre o que significa “ser cubano” e o que é necessário para realizar uma obra que seja relevante tanto localmente quanto internacionalmente. “Posso utilizar o mesmo modelo dentro e fora de Cuba?” – ela se questiona. Sua consciência de viver em uma animada matriz política, de consequências ligadas a ações, proporciona a bússola ética à obra de Bruguera. Esse também foi o foco de nossa conversa que começou no último janeiro na Cidade do México e continuou em Miami e em Nova York.
Provocações de agentes tecnológicos como artistas
Authors: Nunes Fábio Oliveira 
Published: October 2018

O presente artigo propõe uma reflexão sobre processos miméticos que envolvem a atribuição do status de artista a agentes tecnológicos seja emulando o gesto artístico – quando robôs simulam a prática de pintura e desenho – ou assumindo personas criadoras – quando artistas criam personas supostamente com algum poder de criação disseminando--as através das redes digitais. Estas propostas ocupam-se de uma desmitificação crítica do fazer artístico, questionando a figura emblemática do criador ou o seu discurso. Em proximidade a estas reflexões, temos a experimentação de Mimo Steim, onde um suposto artista tecnológico baseado em Linguagem de Marcação de Inteligência Artificial (AIML) conversa com visitantes na web.