bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical benefit of methotrexate plus vinorelbine chemotherapy for desmoid fibromatosis (DF) and correlation of treatment response with MRI
Authors: Ingley Katrina M. , Burtenshaw Sally M. , Theobalds Nicole C. , White Lawrence M. , Blackstein Martin E. , Gladdy Rebecca A. , Thipphavong Seng , Gupta Abha A. 
Published: July 2019

AbstractBackgroundDesmoid fibromatosis (DF) is a rare fibroblastic proliferation that was historically treated with surgery. We report (a) outcomes using low‐dose chemotherapy, methotrexate (MTX), and vinorelbine (VNL) for patients with progressing disease (PD) and (b) whether tumor volume (Vtumor) and T2 signal on magnetic resonance imaging (MRI) are more reflective of treatment response compared with maximum tumor dimension (Dmax) defined by RECIST1.1.MethodsPatients with biopsy‐proven DF, treated with MTX/VNL from 1997 to 2015 were reviewed. MRI for a subset of patients was independently re‐evaluated for response by RECIST, Vtumor, and quantitative T2 hyperintensity.ResultsAmong 48 patients treated for a median 19 months MTX/VNL, only nine (19%) had previous surgery. RECIST‐based overall response rate was complete response (CR) 20 (42%) + partial response (PR) 19 (39%), stable disease (SD) 8 (17%), for a clinical benefit rate of 98%. The median progression‐free survival (PFS) was 120 months, (95%CI 84‐155 months). Thirty‐six (75%) patients had not progressed at a median 38 months from treatment completion. Most common grade 1/2 toxicities included nausea (n = 12, 25%) and fatigue (n = 9,19%) with no grade 3/4 toxicities. In 22 patients with serial MRIs, there was a decrease in Dmax mean by 30%, Vtumor by 76%, and in 19/22 (86%) a decrease in T2 signal intensity.ConclusionLow‐dose MTX/VNL for a defined duration has high efficacy with sustained benefit and minimal toxicity for treating DF. Vtumor and T2 signal might better predict treatment response than RECIST.
Anaerobic Digestion Process of Food Waste for Biogas Production: A Simulation Approach
Authors: Harun Noorlisa , Hassan Zuraini , Zainol Norazwina , Ibrahim Wan Hanisah Wan , Hashim Haslenda 
Published: July 2019

AbstractAnaerobic digestion (AD) involves a series of biological processes in which organic material is broken down and transformed into biogas. A simulation model of the AD process in treating food waste to produce biogas was developed using Aspen Plus software. The components list, thermodynamic property package, reaction list, reactor model, and process condition were specified in Aspen Plus. Sensitivity analysis was performed to study the effect of hydraulic retention time and changes in food waste composition on the biogas production. The methane composition in biogas decreased when the hydraulic retention time was increased which is due to the reduction of substrate consumption during the AD process. The process model is able to represent the AD process and provides a good approximation on the production of biogas under various process operating conditions.
Aqueous‐Phase Reforming in a Microreactor: The Role of Surface Bubbles
Authors: Ripken Renée M. , Wood Jeffery A. , Gardeniers Johannes G. E. , Le Gac Séverine 
Published: July 2019

AbstractIn heterogeneous catalysis, the creation of gaseous products as bubbles in a liquid phase on the catalytic surface is associated with slip phenomena. In a microreactor, the slip length at the gas‐liquid interface is in the same order of magnitude as the reactor dimensions, which can affect fluid dynamics and transport phenomena. Here, the interplay of momentum, heat and mass transfer in a microreactor, when bubbles form on the catalytic surface, was investigated using two‐dimensional simulations. The effect of bubbles on the endothermic process of aqueous‐phase reforming of a glycerol solution was evaluated in terms of conversion and conversion and temperature in the reactor. Altogether, this study highlights the impact of bubbles, not only on the transport phenomena but also on the reactor performance.
Practical Continuous‐Flow Controlled/Living Anionic Polymerization
Authors: Nakahara Yuichi , Furusawa Mai , Endo Yuta , Shimazaki Toshiya , Ohtsuka Keita , Takahashi Yusuke , Jiang Yiyuan , Nagaki Aiichiro 
Published: July 2019

AbstractA continuous‐flow reaction system was developed, allowing flow conditions of the entire system to be maintained at a predetermined constant level, which is one of the most significant factors for successful industrial application. Controlled/living anionic polymerization was selected as a model reaction since the characteristics of its polymer products, molecular weights, and molecular weight distributions are highly susceptible to changes in the relative flow rates of a monomer and initiator solutions. In flow microreactors, controlled/living anionic polymerization of styrene in tetrahydrofuran (THF)/hexane initiated by THF‐diluted n‐butyllithium (n‐BuLi) was examined. Poly(styrenes) of larger molecule sizes such as Mn > 15 000 were successfully synthesized. After continuous operation for four hours, ca. 0.5 kg of the polymer was readily produced with narrow molecular weight distribution, demonstrating the applicability of this continuous‐flow system for controlled/living anionic polymerization on considerably large scale with a view to its industrial usage in the future.
Multiaxial and variable amplitude fatigue of concrete
Authors: Heek Peter , Mark Peter 
Published: July 2019

AbstractConcrete structures are often exposed to cyclic loads induced by traffic or machine vibrations. To assess fatigue lifes, SN curves serve, which are usually validated by experiments. During testing, reference specimens are exposed to uniaxial and constant amplitude fatigue. However, under real operating conditions loads occur multiaxially and with alternating amplitude and frequency. Thus, the progressively increasing material damage has to be mathematically captured. In this regard, Palmgren‐Miner's linear accumulation rule is well established, although it neglects distinct sequence effects. In the article, the SN concept is first extended to multiaxial stress states by introducing an equivalent stress under the notion of isotropic damage. Then, a modified damage accumulation procedure is developed taking into account effects of loading and unloading on residual numbers of cycles to failure in multistage loading processes. The new approach is verified to experimental data taken from the literature and elaborated to a design chart. An example demonstrates the practical application.
Concise and Additive‐Free Click Reactions between Amines and CF3SO3CF3
Authors: Song Hai‐Xia , Han Zhou‐Zhou , Zhang Cheng‐Pan 
Published: July 2019

AbstractTrifluoromethyl trifluoromethanesulfonate has proved to be an excellent reservoir of difluorophosgene and a promising click ligation for amines in the preparation of urea derivatives, heterocycles, and carbamoyl fluorides under metal‐ and additive‐free conditions. The reactions are rapid, efficient, selective, and versatile, and can be performed in benign solvents, giving products in excellent yields with minimal efforts for purification. The characteristics of the reactions meet the requirements of a click reaction. The use of trifluoromethyl trifluoromethanesulfonate as a click reagent is advantageous over other “CO” sources (e.g., TsOCF3, PhCO2CF3, CsOCF3, AgOCF3, and triphosgene) because this reagent is readily accessible; easy to scale up; and highly reactive, even under metal‐ and additive‐free conditions. It is anticipated that CF3SO3CF3 will be increasingly as important as SO2F2 as a click agent in future drug design and development.
Isolation, Purification, Characterization and Direct Conjugation of the Lipid A‐Free Lipopolysaccharide of Vibrio cholerae O139
Authors: Xu Peng , Korcová Jana , Baráth Peter , Čížová Alžbeta , Valáriková Jana , Qadri Firdausi , Kelly Meagan , O'Connor Robert D. , Ryan Edward T. , Bystrický Slavomír , Kováč Pavol 
Published: July 2019

AbstractThe lipopolysaccharide (LPS) of Vibrio cholerae O139, strain CIRS245, was isolated conventionally, and the lipid A was removed by mild acid hydrolysis (0.1 m NaOAc buffer containing 1 % SDS, pH 4.2, 95 °C, 8 h). The crude product was a complex mixture consisting mainly of constituent fragments of the O‐specific polysaccharide‐core (OSPc). The OSPc was only a minor component in the mixture. Two‐stage purification of the crude OSPc by HPLC gave pure OSPc fragment of the LPS, as shown by NMR spectroscopy, analytical HPLC and ESI‐MS. This material is the purest OSPc fragment of the LPS from Vibrio cholerae O139 reported to date. The purified OSPc was readily converted to the corresponding methyl squarate derivative and the latter was conjugated to BSA. The conjugate, when examined by ELISA, showed immunoreactivity with sera from patients in Bangladesh recovering from cholera caused by V. cholerae O139, but not O1.
Through‐Space Spin Coupling in a Silver(II) Porphyrin Dimer upon Stepwise Oxidations: AgII⋅⋅⋅AgII, AgII⋅⋅⋅AgIII, and AgIII⋅⋅⋅AgIII Metallophilic Interactions
Authors: Singh Akhil Kumar , Usman Mohammad , Sciortino Giuseppe , Garribba Eugenio , Rath Sankar Prasad 
Published: July 2019

AbstractInvited for the cover of this issue are Sankar Prasad Rath and co‐workers at the Indian Institute of Technology (IIT Kanpur) and the University of Sassari. The image depicts through space interactions in a cofacial AgII porphyrin dimer upon stepwise oxidations, which allow the estimation of the structure and energy characteristics of metallophilic interactions between AgII/AgII (d9/d9), AgIII/AgIII (d8/d8) and also mixed‐valent AgII/AgIII (d9/d8) complexes. Read the full text of the article at 10.1002/chem.201901731.
Predicting Sequence Features, Function, and Structure of Proteins Using MESSA
Authors: Bhat Archana S. , Grishin Nick V. 
Published: July 2019

AbstractMEta‐Server for protein Sequence Analysis (MESSA) is a tool that facilitates widespread protein sequence analysis by gathering structural (local sequence properties and three‐dimensional structure) and functional (annotations from SWISS‐PROT, Gene Ontology terms, and enzyme classification) predictions for a query protein of interest. MESSA uses multiple well‐established tools to offer consensus‐based predictions on important aspects of protein sequence analysis. Being freely available for noncommercial users and with a user‐friendly interface, MESSA serves as an umbrella platform that overcomes the absence of a comprehensive tool for predictive protein analysis. This article reveals how to access MESSA via the Web and shows how to input a protein sequence to analyze using the MESSA web server. It also includes a detailed explanation of the output from MESSA to aid in better interpretation of results. © 2019 by John Wiley & Sons, Inc.
Are we ready to develop a tiered scheme for the effusion cytology? A comprehensive review and analysis of the literature
Authors: Farahani Sahar J. , Baloch Zubair 
Published: July 2019

AbstractBackgroundCytology is widely utilized in the initial evaluation of fluid accumulation in the body cavities. The aim of this study was to determine the accuracy of cytology in distinguishing between benign and malignant (MAL) effusions.MethodsA comprehensive and systematic review of the literature was conducted to evaluate the accuracy of serous effusion cytology (SEC) against tissue biopsy/resection histology, imaging, or clinical follow‐up as the reference test. Risk of publication bias and level of heterogeneity in the included studies was assessed. Meta‐regression was performed to assess the effect of various variables on the accuracy of SEC.ResultsEighty studies met the inclusion criteria for meta‐analysis comprising of 34 941 samples; of which 52 (0.2%), 22 202 (72.7%), 194 (0.6%), 711 (2.3%), and 6507 (21.3%) could be reclassified as nondiagnostic (ND), negative for malignancy (NFM), atypical (atypia of uncertain significance—AUS), suspicious for malignancy (SFM), and malignant (MAL), respectively. On follow‐up, the mean risk of malignancy for ND, NFM, AUS, SFM, MAL was 17.4%, 20.7%, 65.9%, 81.8%, and 98.9%, respectively. A total of 73 studies were included in estimating the diagnostic accuracy of SEC. The bivariate mixed‐effect model estimated the SEC sensitivity, specificity, diagnostic odds ratio, positive likelihood ratio, and negative likelihood ratio as 73.1%, 99.9%, 7850.6%, 2112.2%, and 0.27%, respectively.ConclusionSerous effusion cytology shows high specificity and moderate sensitivity in the evaluation of serous effusions. A tiered classification scheme can improve the consistency of terminology for reporting SEC results, thus improving communication between the pathologists and clinical team, and quality of patient care.
Dimethylaminoparthenolide reduces the incidence of dysplasia and ameliorates a wasting syndrome in HPV16‐transgenic mice
Authors: Santos Joana M. O. , Moreira‐Pais Alexandra , Neto Tiago , Peixoto da Silva Sara , Oliveira Paula A. , Ferreira Rita , Mendes Joaquim , Bastos Margarida M. S. M. , Lopes Carlos , Casaca Fátima , Silva Sandra , Sweeney Christopher , Medeiros Rui , Gil da Costa Rui M. 
Published: July 2019

AbstractThe nuclear factor kappa light chain enhancer of activated B cells (NF‐κB) has been implicated in the progression of cancers induced by high‐risk human papillomaviruses (HPV). In cancer patients, NF‐κB is also thought to drive a chronic systemic inflammatory status, leading to cachexia. This study addressed the ability of dimethylaminoparthenolide (DMAPT), a water‐soluble NF‐κB inhibitor, to block the development of HPV‐induced lesions and wasting syndrome in HPV16‐transgenic mice. Mice received DMAPT orally (100 mg/kg/day), once a day, for 6 consecutive weeks. Body weight was monitored weekly along with food and water intake. After 6 weeks the animals were submitted to a grip strength test and sacrificed for specimen collection. Skin samples were analyzed histologically and for expression of NF‐κB‐regulated genes Bcl2 and Bcl2l1. Gastrocnemius muscles were weighted and analyzed for expression of NF‐κB subunits p50, p52, p65, and Rel‐B. DMAPT reduced the incidence of epidermal dysplasia (18.2% versus 33.3% in HPV16+/− untreated mice). This was associated with reduced expression of Bcl2 and Bcl2l1 (p = .0003 and p = .0014, respectively) and reduced neutrophilic infiltration (p = .0339). Treated mice also showed partially preserved bodyweight and strength, which were independent of the expression levels of NF‐κB subunits in skeletal muscle.These results suggest that NF‐κB inhibition may be a valid strategy against HPV‐induced lesions in vivo and warrant further preclinical tests particularly in the set of combination therapies. In addition, the data may support the use of DMAPT to prevent wasting syndrome.
Profiling of synthesis‐related impurities of the synthetic cannabinoid Cumyl‐5F‐PINACA in seized samples of e‐liquids via multivariate analysis of UHPLC−MSn data
Authors: Münster‐Müller Sascha , Matzenbach Isabelle , Knepper Thomas , Zimmermann Ralf , Pütz Michael 
Published: July 2019

AbstractVaping of synthetic cannabinoids via e‐cigarettes is growing in popularity. In the present study, we tentatively identified 12 by‐products found in a pure sample of the synthetic cannabinoid Cumyl‐5F‐PINACA (1‐(5‐fluoropentyl)‐N‐(2‐phenylpropan‐2‐yl)‐1H‐indazole‐3‐carboxamide), a prevalent new psychoactive substance (NPS) in e‐liquids, via high‐resolution mass spectrometry fragmentation experiments (HRMS/MS). Furthermore, we developed a procedure to reproducibly extract this synthetic cannabinoid and related by‐products from an e‐liquid matrix via chloroform and water. The extracts were submitted to flash chromatography (F‐LC) to isolate the by‐products from the main component. The chromatographic impurity signature was subsequently assessed by ultra‐high‐performance liquid chromatography coupled to mass spectrometry (UHPLC–MS) and evaluated by automated integration. The complete sample preparation sequence (F‐LC + UHPLC–MS) was validated by comparing the semi‐quantitative signal integrals of the chromatographic impurity signatures of five self‐made e‐liquids with varying concentrations of Cumyl‐5F‐PINACA [0.1, 0.2, 0.5, 0.7 and 1.0% (w/w)], giving an average relative standard deviation of 6.2% for triplicate measurements of preparations of the same concentration and 10.5% between the measurements of the five preparations with different concentrations. Lastly, the chromatographic signatures of 14 e‐liquid samples containing Cumyl‐5F‐PINACA from police seizures and Internet test purchases were evaluated via hierarchical cluster analysis for potential links. For the e‐liquid samples originating from test purchases, it was found that the date of purchase, the identity of the online shop, and the brand name are the critical factors for clustering of samples.
Budesonide use and misuse in sports: Elimination profiles of budesonide and metabolites after intranasal, high‐dose inhaled and oral administrations
Authors: Coll Sergi , Monfort Núria , Matabosch Xavier , Papakonstantinou Katerina , Pérez‐Mañá Clara , Mateus Julian A. , Ventura Rosa 
Published: July 2019

AbstractBudesonide (BUD) is a glucocorticoid (GC) widely used in therapeutics. In sports, the World Anti‐doping Agency (WADA) controls the use of GCs, and WADA‐accredited laboratories use a reporting level of 30 ng/mL for 6β‐hydroxy‐budesonide (6βOHBUD) to detect the systemic administration of BUD. In the present work, we examined the urinary excretion profile of 6βOHBUD, BUD, and 16α‐hydroxy‐prednisolone (16αOHPRED) after intranasal (INT), inhaled (INH) (at high doses) and oral administrations in male and female volunteers. BUD was administered to healthy volunteers using INT route (256 μg/day for three days, n = 4 males and 4 females), INH route (800 μg/day for three days, n = 4 males and 4 females, and 1600 μg/day for three days, n = 4 males) or oral route (3 mg, n = 8 females). Urine samples were collected before and after administration at different time periods, and were analyzed by liquid chromatography–tandem mass spectrometry. 6βOHBUD and BUD concentrations were very low after INT treatment (0.0–7.1 and 0.0–8.1 ng/mL, respectively), and higher after INH treatments (0.0–35.4 and 0.0–48.3 ng/mL, respectively). For 16αOHPRED, elevated concentrations were detected after INT and INH treatments (2.6–66.4 and 3.4–426.5 ng/mL, respectively). Concentrations obtained following oral administration were higher than after therapeutic administrations (2.8–80.6, 1.5–36.1, and 10.4–532.2 ng/mL for 6βOHBUD, BUD, and 16αOHPRED, respectively). After all administrations, concentrations were higher in males than in females. Results demonstrated that 6βOHBUD is the best discriminatory marker and a reporting level of 40 ng/mL was found to be the best criterion to distinguish allowed from forbidden administrations of BUD.
Targeted exome sequencing reveals a novel GLI3 mutation in a Chinese family with nonsyndromic polydactyly
Authors: Zhao Xiangyu , Xu Hongyan , Liu Xiaxia , Li Lin 
Published: July 2019

AbstractBackgroundPolydactyly is a phenotypically and genetically highly heterogeneous limb malformation with preaxial, postaxial, and central subtypes. The aim of this study was to identify genetically pathogenic factor in a Chinese nonsyndromic polydactyly family.ResultsSeven family members and 100 healthy controls were recruited, and the genetically pathogenic factor of the polydactyly family was investigated by targeted exome sequencing. Targeted exome sequencing revealed a novel frameshift mutation c.2148delA (p.Gln716Hisfs*17) of GLI3 in the family. This GLI3 variant was absent in 100 healthy controls and predicted to be highly damaging to the function of the GLI3 by causing half truncation of the protein.ConclusionThis novel variant extended the mutational and phenotypic spectra of GLI3 and demonstrated the feasibility of targeted exome sequencing in clinical application of molecular diagnosis.
Leadership and the contagion of affective phenomena: A systematic review and mini meta‐analysis
Authors: Clarkson Beth G. , Wagstaff Christopher R. D. , Arthur Calum A. , Thelwell Richard C. 
Published: July 2019

AbstractWe present a systematic review of literature examining leadership and the contagion of affective phenomena, namely emotion, mood, and affect. Specifically, an inductive thematic analysis approach was adopted to synthesize the findings from published studies. In addition, a mini meta‐analysis was conducted to quantify reported effects. A rigorous search identified 25 studies that fulfilled the inclusion criteria for further review. Results highlighted important relationships between leadership and contagion aligned with six themes: Charismatic and transformational leadership are conducive to contagion of leader and follower positive affective phenomena; greater contagion effects exists when there is congruence between leader and follower affective states; contagion of leader and follower affective phenomena is directly linked to leader effectiveness and performance; and, individual susceptibility to the contagion of affective phenomena can moderate these relationships. These findings have salient implications for conceptualization and measurement across multiple lines of inquiry and within numerous domains of application.
Factors affecting accuracy in the quality control checking of fresh produce labels: A situational and laboratory‐based exploration
Authors: Smith‐Spark James H. , Katz Hillary B. , Wilcockson Thomas D. W. , Marchant Alexander P. 
Published: July 2019

AbstractManufacturing industries often rely on quality control staff to ensure mistakes are detected before products are shipped to customers. Undetected errors can result in large financial and environmental costs to packaging companies and supermarkets but the contributors to such error are underexplored. The research reported in this paper investigated human error in the quality control checking of information displayed on the labels which accompany packaged fresh produce. Initial work sought to understand the demands of label‐checking in the packhouse environment, through interviews with key quality control staff, in situ observations, and the study of historical error data held by a fresh produce packaging company. This study highlighted the dynamic and cognitively challenging environment in which label‐checking occurred, while the historical error data indicated both the scale of the packhouse's work and the infrequency of error occurring. In a separate strand of laboratory‐based research, experienced and novice label‐checkers were presented with a simulated label‐checking task and a battery of computerized and pen‐and‐paper tests. These tasks were administered to determine whether cognitive abilities could predict label‐checking accuracy in a controlled laboratory environment. Stronger abilities in two cognitive processes (information processing speed and inhibition) predicted greater overall accuracy and higher detection of labeling errors. In identifying potential contributors to human error in the quality control checking of product labels both in situ and in the laboratory, the results are relevant to manufacturing, wherever information is printed on labels, especially when labeling processes depend upon human data entry and human quality control checking.