bluuebunny/crossref_metadata_2025_split huggingface dataset:
NF-κB-related decrease of glioma angiogenic potential by graphite nanoparticles and graphene oxide nanoplatelets
Authors: Wierzbicki Mateusz , Sawosz Ewa , Strojny Barbara , Jaworski Sławomir , Grodzik Marta , Chwalibog André 
Published: September 2018

AbstractGliomas develop an expanded vessel network and a microenvironment characterized by an altered redox environment, which produces high levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) that fuel its growth and malignancy. ROS and RNS can influence tumor cell malignancy via the redox-regulated transcription factor NF-κB, whose activation is further regulated by the mutation status of p53. The objective of this study was to assess the influence of graphite nanoparticles (NG) and graphene oxide nanoplatelets (nGO) on the angiogenic potential of glioma cell lines with different p53 statuses. Nanoparticle treatment of glioma cells decreased the angiogenesis of human umbilical vein endothelial cells (HUVEC) cocultured with U87 (p53 wild type) and was not effective for U118 (p53 mutant) cells. Nanoparticle activity was related to the decreased level of intracellular ROS and RNS, which downregulated NF-κB signaling depending on the p53 status of the cell line. Activation of NF-κB signaling affected downstream protein levels of interleukin 6, interleukin 8, growth-regulated oncogene α, and monocyte chemotactic protein 1. These results indicate that the activity of NG and nGO can be regulated by the mutation status of glioma cells and therefore give new insights into the use of nanoparticles in personalized biomedical applications regarding glioma angiogenesis and its microenvironment.
Impact of an infectious diseases specialist-led antimicrobial stewardship programmes on antibiotic use and antimicrobial resistance in a large Korean hospital
Authors: Hwang Hyeonjun , Kim Bongyoung 
Published: September 2018

AbstractThe aim of this study was to evaluate the impact of an infectious diseases specialist (IDS)-led antimicrobial stewardship programmes (ASPs) in a large Korean hospital. An interrupted time series analysis assessing the trends in antibiotic use and antimicrobial resistance rate of major pathogens between September 2015 and August 2017 was performed in an 859-bed university-affiliated hospital in Korea. The restrictive measure for designated antibiotics led by an IDS reduced carbapenems usage by −4.57 days of therapy (DOT)/1,000 patient-days per month in general wards (GWs) (95% confidence interval [CI], −6.69 to −2.46; P < 0.001), and by −41.50 DOT/1,000 patient-days per month in intensive care units (ICUs) (95% CI, −57.91 to −25.10; P < 0.001). Similarly, glycopeptides usage decreased by −2.61 DOT/1,000 patient-days per month in GWs (95% CI, −4.43 to −0.79; P = 0.007), and −27.41 DOT/1,000 patient-days per month in ICUs (95% CI, −47.03 to −7.79; P = 0.009). Use of 3rd generation cephalosporins, beta-lactam/beta-lactamase inhibitors, and fluoroquinolones in GWs showed change comparable with that of carbapenems or glycopeptides use. Furthermore, trends of antimicrobial resistance rate of Staphylococcus aureus to gentamicin in GWs, Staphylococcus aureus to ciprofloxacin and oxacillin in ICUs, and Pseudomonas aeruginosa to imipenem in ICUs decreased in slope in the intervention period. The in-hospital mortality rate per 1,000 patient-days among ICU patients remained stable between the pre-intervention and intervention periods. In conclusion, an IDS-led ASPs could enact a meaningful reduction in antibiotic use, and a decrease in antibiotic resistance rate, without changing mortality rates in a large Korean hospital.
Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors
Authors: Noori Hamid R. , Mücksch Christian , Vengeliene Valentina , Schönig Kai , Takahashi Tatiane T. , Mukhtasimova Nuriya , Bagher Oskouei Maryam , Mosqueira Matias , Bartsch Dusan , Fink Rainer , Urbassek Herbert M. , Spanagel Rainer , Sine Steven M. 
Published: September 2018

AbstractAlcohol consumption affects many organs and tissues, including skeletal muscle. However, the molecular mechanism of ethanol action on skeletal muscle remains unclear. Here, using molecular dynamics simulations and single channel recordings, we show that ethanol interacts with a negatively charged amino acid within an extracellular region of the neuromuscular nicotinic acetylcholine receptor (nAChR), thereby altering its global conformation and reducing the single channel current amplitude. Charge reversal of the negatively charged amino acid abolishes the nAChR-ethanol interaction. Moreover, using transgenic animals harboring the charge-reversal mutation, ex vivo measurements of muscle force production show that ethanol counters fatigue in wild type but not homozygous αE83K mutant animals. In accord, in vivo studies of motor coordination following ethanol administration reveal an approximately twofold improvement for wild type compared to homozygous mutant animals. Together, the converging results from molecular to animal studies suggest that ethanol counters muscle fatigue through its interaction with neuromuscular nAChRs.
Multiple self-healing Bloch surface wave beams generated by a two-dimensional fraxicon
Authors: Kim Myun-Sik , Vetter Andreas , Rockstuhl Carsten , Lahijani Babak Vosoughi , Häyrinen Markus , Kuittinen Markku , Roussey Matthieu , Herzig Hans Peter 
Published: September 2018

AbstractTwo-dimensional surface waves are a cornerstone for future integrated photonic circuits. They can also be beneficially exploited in sensing devices by offering dark-field illuminations of objects. One major problem in sensing schemes arises from the individual sensing objects: the interaction of surface waves with an object reduces the field amplitude, and the readout of other objects along the propagation path suffers from this reduced signal. Here we show in two experiments that nondiffracting and self-healing Bloch surface waves can be launched using a Fresnel axicon (i.e., fraxicon). First, we visualize the generation of an array of multiple focal spots by scanning near-field optical microscopy in the infrared. With a second device operating in the visible, we demonstrate the self-healing effect directly using a far-field readout method by placing metallic nanoantennas onto the multiple focal spots of the fraxicon. Our study extends the versatile illumination capabilities of surface wave systems.
Radio observations of the merging galaxy cluster Abell 520
Authors: Hoang D. N. , Shimwell T. W. , van Weeren R. J. , Brunetti G. , Röttgering H. J. A. , Andrade-Santos F. , Botteon A. , Brüggen M. , Cassano R. , Drabent A. , de Gasperin F. , Hoeft M. , Intema H. T. , Rafferty D. A. , Shweta A. , Stroe A. 
Published: September 2018

Context. Extended synchrotron radio sources are often observed in merging galaxy clusters. Studies of the extended emission help us to understand the mechanisms in which the radio emitting particles gain their relativistic energies.
Aims. We examine the possible acceleration mechanisms of the relativistic particles that are responsible for the extended radio emission in the merging galaxy cluster Abell 520.
Methods. We performed new 145 MHz observations with the LOw Frequency ARay (LOFAR) and combined these with archival Giant Metrewave Radio Telescope (GMRT) 323 MHz and Very Large Array (VLA) 1.5 GHz data to study the morphological and spectral properties of extended cluster emission. The observational properties are discussed in the framework of particle acceleration models associated with cluster merger turbulence and shocks.
Results. In Abell 520, we confirm the presence of extended (760 × 950 kpc2) synchrotron radio emission that has been classified as a radio halo. The comparison between the radio and X-ray brightness suggests that the halo might originate in a cocoon rather than from the central X-ray bright regions of the cluster. The halo spectrum is roughly uniform on the scale of 66 kpc. There is a hint of spectral steepening from the SW edge towards the cluster centre. Assuming diffusive shock acceleration (DSA), the radio data are suggestive of a shock Mach number of ℳSW = 2.6−0.2+0.3
that is consistent with the X-ray derived estimates. This is in agreement with the scenario in which relativistic electrons in the SW radio edge gain their energies at the shock front via acceleration of either thermal or fossil electrons. We do not detect extended radio emission ahead of the SW shock that is predicted if the emission is the result of adiabatic compression. An X-ray surface brightness discontinuity is detected towards the NE region that may be a counter shock of Mach number ℳNEX = 1.52±0.05. This is lower than the value predicted from the radio emission which, assuming DSA, is consistent with ℳNE = 2.1 ± 0.2.
Conclusions. Our observations indicate that the radio emission in the SW of Abell 520 is likely effected by the prominent X-ray detected shock in which radio emitting particles are (re-)accelerated through the Fermi-I mechanism. The NE X-ray discontinuity that is approximately collocated with an edge in the radio emission hints at the presence of a counter shock.
Evidence for a massive dust-trapping vortex connected to spirals
Authors: Cazzoletti P. , van Dishoeck E. F. , Pinilla P. , Tazzari M. , Facchini S. , van der Marel N. , Benisty M. , Garufi A. , Pérez L. M. 
Published: September 2018

Context. Spiral arms, rings and large scale asymmetries are structures observed in high resolution observations of protoplanetary disks, and it appears that some of the disks showing spiral arms in scattered light also show asymmetries in millimeter-sized dust. HD 135344B is one such disk. Planets are invoked as the origin of these structures, but no planet has been observed so far and upper limits are becoming more stringent with time.
Aims. We want to investigate the nature of the asymmetric structure in the HD 135344B disk in order to understand the origin of the spirals and of the asymmetry seen in this disk. Ultimately, we aim to understand whether or not one or more planets are needed to explain such structures.
Methods. We present new ALMA sub-0.1′′ resolution observations at optically thin wavelengths (λ = 2.8 and 1.9 mm) of the HD 135344B disk. The high spatial resolution allows us to unambiguously characterize the mm-dust morphology of the disk. The low optical depth of continuum emission probes the bulk of the dust content of the vortex. Moreover, we have combined the new observations with archival data at shorter wavelengths to perform a multi-wavelength analysis and to obtain information about the dust distribution and properties inside the observed asymmetry.
Results. We resolve the asymmetric disk into a symmetric ring + asymmetric crescent, and observe that (1) the spectral index strongly decreases at the centre of the vortex, consistent with the presence of large grains; (2) for the first time, an azimuthal shift of the peak of the vortex with wavelength is observed; (3) the azimuthal width of the vortex decreases at longer wavelengths, as expected for dust traps. These features allow confirming the nature of the asymmetry as a vortex. Finally, under the assumption of optically thin emission, a lower limit to the total mass of the vortex is 0.3MJupiter. Considering the uncertainties involved in this estimate, it is possible that the actual mass of the vortex is higher and possibly within the required values (~4 MJupiter) to launch spiral arms similar to those observed in scattered light. If this is the case, then explaining the morphology does not require an outer planet.
Wenn Eingeweide ausstrahlen
Authors: Ermel Johannes 
Published: September 2018

SummaryEin Grund für therapieresistente Beschwerden kann sein, dass Auslöser und Schmerzbereich nicht identisch sind. Oftmals strahlen muskuloskeletale Strukturen in andere Bereiche aus. Doch auch innere Organe können dafür verantwortlich sein, dass sich Schmerzen im Bewegungssystem trotz langer Therapie nicht verbessern.
Abscesos prostáticos y manejo con resección transuretral de próstata
Authors: Cárdenas Walter Bacaret , Puentes Andrés Felipe , Piraquive Sebastián Rodríguez , Corredor Héctor , Capera Cesar Andrés , Donoso Wilfredo 
Published: September 2018

Resumen
Objetivos Caracterizar una serie de pacientes con abscesos prostáticos tratados con resección transuretral de próstata, analizar los factores de riesgo, y los resultados del tratamiento.
Métodos Se realizó un estudio retrospectivo de 2015 a 2016 en 2 hospitales de III y IV nivel en la ciudad de Bogotá en pacientes con diagnóstico tomográfico de absceso prostático, tratados con resección transuretral de próstata.
Resultados Se documentaron 6 casos de hombres diagnosticados con absceso prostático con edad promedio de 57 años (40-78 años) que fueron llevados a RTUP para el drenaje del absceso. El promedio de hospitalización fue de 11.4 días (3-34 días); el aislamiento microbiológico positivo se alcanzó en el 83% de los pacientes. El 50% de los pacientes usaban sonda uretral a permanencia. La curación fue completa.
Conclusiones La RTU de próstata en el drenaje de abscesos prostáticos, es un tratamiento seguro y eficaz en logrando resolución completa de la enfermedad.
Successful Use of Recombinant Activated Factor VII to Reverse Ticagrelor-Induced Bleeding Risk: A Case Report
Authors: Godier Anne , Dupont Mélanie , Desilles Jean-Philippe , Le Guerinel Caroline , Taylor Guillaume , Perrin Mathilde , Martin Anne-Céline , Gaussem Pascale 
Published: September 2018

AbstractManagement of ticagrelor-associated bleeding is challenging, especially in neurosurgery. Platelet transfusion is inefficient and no antidote is currently available. We report here the first case of recombinant activated factor VII (rFVIIa) use to bypass ticagrelor-induced platelet inhibition. A woman treated with ticagrelor and requiring emergent neurosurgery for an intracranial hematoma received preoperative high-dose platelet transfusion and 60 μg/kg rFVIIa. Laboratory monitoring demonstrated that platelet transfusion failed to reverse ticagrelor-induced platelet inhibition while rFVIIa improved hemostasis by shortening the thromboelastometric clotting time. Neurosurgery occurred without any bleeding event but the patient presented with a postoperative pulmonary embolism. In conclusion, rFVIIa may decrease ticagrelor-induced bleeding risk but careful assessment of the benefit-risk balance is warranted before using rFVIIa to reverse ticagrelor effects.
Passing on the experience of psychotherapy and healing
Authors: Capella Claudia , Rodríguez Loreto , Lama Ximena , Beiza Gretchen 
Published: September 2018

AbstractDeveloped in the context of a larger research study on healing from sexual abuse, the present article analyzes written narratives (letters) produced by nine adolescents who have been victims of sexual assault and who successfully completed a specialized psychotherapy. Letters, directed to another child or adolescent starting their therapy in the same center, were analyzed using three integrated types of narrative analysis (thematic, structural and performative).Key findings show that narratives exhibit messages of hope and encouragement, and adolescents view themselves as agents involved in their own transformation. In their letters, they urge other young children and adolescents to become actively involved in their own healing process. Participants stress the role of psychotherapy and therapeutic support in their recovery from sexual abuse.Results are discussed highlighting the use of letters in clinical practice on adolescent sexual assault. Integration of multiple types of narrative analysis is discussed as a methodological support.
A story more real than reality
Authors: Rautajoki Hanna 
Published: September 2018

AbstractThis article examines the concept of experientiality in conversational storytelling from an ethnomethodological perspective, introducing a case in which the narrative mediation of experience fails. The recipient misses the experiential point of the story in the flow of interaction, which stems from other reasons than a failure in sense-making or cognitive comprehension. I discuss my findings with Monika Fludernik’s influential theory of Natural Narratology, according to which all narratives concern experiential exchange between the teller and the recipient, which travels from one consciousness to the other through natural cognitive parameters grounded in real life schemata. Applying conversation analysis, I focus on scrutinizing the details of the turn-by-turn unfolding activities of the participants. My analysis demonstrates that Fludernik’s conception of naturality falls short in capturing the relevancies of naturally occurring storytelling. Ignoring the reflexive intentionality of telling and reception makes Natural Narratology ill-equipped to grasp the dynamics of experientiality in everyday narration.
Overexpression of MinE gene affects the plastid division in cassava
Authors: Wang Cong-Cong , Ke Lei , Cao Liang-Jing , Yao Yuan , Geng Meng-Ting , Wang Ying , Xiao Yu , Huang Wu , Liu Xiao-Han , Cao Peng , Guo Jian-Chun , Min Yi 
Published: September 2018

ABSTRACT
The MinE protein plays an important role in plastid division. In this study, the MinE gene was isolated from the cassava (Manihot esculenta Crantz) genome. We isolated high quality and quantity protoplasts and succeed in performing the transient expression of the GFP-fused Manihot esculenta MinE (MeMinE) protein in cassava mesophyll protoplasts. The transient expression of MeMinE-GFP in cassava protoplasts showed that the MeMinE protein was located in the chloroplast. Due to the abnormal division of chloroplasts, overexpression of MeMinE proteins in cassava mesophyll protoplasts could result in fewer and smaller chloroplasts. Overexpression of MeMinE proteins also showed abnormal cell division characteristics and minicell occurrence in Escherichia coli caused by aberrant septation events in the cell poles.
Existence of Self-similar Solutions to the Anisotropic Affine Curve-shortening Flow
Authors: Lu Jian 
Published: September 2018

Abstract
In this paper the existence of positive $2\pi $-periodic solutions to the ordinary differential equation $$\begin{equation*} u^{\prime\prime}+u=\frac{f}{u^3} \ \textrm{ in } \mathbb{R} \end{equation*}$$is studied, where $f$ is a positive $2\pi $-periodic smooth function. By virtue of a new generalized Blaschke–Santaló inequality, we obtain a new existence result of solutions.
Changing Landscape of Liver Cancer in California: A Glimpse Into the Future of Liver Cancer in the United States
Authors: Han Summer S , Kelly Scott P , Li Yuqing , Yang Baiyu , Nguyen Mindie , So Samuel , Rosenberg Philip S , Hsing Ann W 
Published: September 2018

Abstract

Background
Asians and Hispanics currently have the highest incidence rates of hepatocellular carcinoma (HCC) in the United States. The numbers of these minority populations are rapidly increasing, reshaping the demographic in the United States and particularly California, where approximately one-third of US Asians and Hispanics reside. With the changing demographic and rising incidence of HCC that has tripled during the past three decades, it is important to forecast the future burden of HCC by age, sex, and race/ethnicity to plan prevention and control strategies for HCC.

Methods
We used four Surveillance, Epidemiology, and End Results Program registries to obtain incidence data for California during 2000 to 2013, and 14 registries to represent non-California states. We applied age-period-cohort models to estimate future HCC incidence rates, and estimated HCC burden by multiplying incidence forecasts by corresponding US Census population projections.

Results
Our forecasts for California suggest that in 2030 Hispanics and blacks will have the highest HCC incidence rates and Asians the lowest. While incidence among whites, blacks, and Hispanics in California increased successively for each birth year cohort from 1915 through 1955, incidence among Asians in California decreased for each successive birth year cohort from 1915 through 1975. In contrast, consistent declines were not seen among Asians in the rest of the United States. In California, the estimated burden of HCC is 6482 new cases in 2030, where 80.0% of these patients are older than 65 years (vs 44.5% in 2014). The relative increase of burden in 2030 vs 2014 for this 65 years and older age group is especially high among Hispanics (318.3%), whereas it is the lowest among Asians (53.2%) in California.

Conclusions
Prevention efforts in California should target persons currently ages 50 to 64 years who will make up the older age group (&gt;65 years) in 2030, especially among Hispanics with the most rapid increase of HCC burden through 2030.
A Connectomic Atlas of the Human Cerebrum—Chapter 3: The Motor, Premotor, and Sensory Cortices
Authors: Baker Cordell M , Burks Joshua D , Briggs Robert G , Sheets John R , Conner Andrew K , Glenn Chad A , Sali Goksel , McCoy Tressie M , Battiste James D , O’Donoghue Daniel L , Sughrue Michael E 
Published: September 2018

ABSTRACT
In this supplement, we build on work previously published under the Human Connectome Project. Specifically, we show a comprehensive anatomic atlas of the human cerebrum demonstrating all 180 distinct regions comprising the cerebral cortex. The location, functional connectivity, and structural connectivity of these regions are outlined, and where possible a discussion is included of the functional significance of these areas. In part 3, we specifically address regions relevant to the sensorimotor cortices.
A Connectomic Atlas of the Human Cerebrum—Chapter 12: Tractographic Description of the Middle Longitudinal Fasciculus
Authors: Conner Andrew K , Briggs Robert G , Rahimi Meherzad , Sali Goksel , Baker Cordell M , Burks Joshua D , Glenn Chad A , Battiste James D , Sughrue Michael E 
Published: September 2018

ABSTRACT
The middle longitudinal fasciculus (MdLF) is a small and somewhat controversial white matter tract of the human cerebrum, confined to the posterior superior temporal region from which it courses posteriorly to connect at the occipital–parietal interface. The tract appears to be involved in language processing as well as auditory organization and localization, while sub-serving other higher level cognitive functions that have yet to be fully elucidated. Little is known about the specific, interparcellation connections that integrate to form the MdLF. Utilizing diffusion spectrum magnetic resonance imaging tractography coupled with the human cortex parcellation data presented earlier in this supplement, we aim to describe the macro-connectome of the MdLF in relation to the linked parcellations present within the human cortex. The purpose of this study is to present this information in an indexed, illustrated, and tractographically aided series of figures and tables for anatomic and clinical reference.
A Connectomic Atlas of the Human Cerebrum—Chapter 13: Tractographic Description of the Inferior Fronto-Occipital Fasciculus
Authors: Conner Andrew K , Briggs Robert G , Sali Goksel , Rahimi Meherzad , Baker Cordell M , Burks Joshua D , Glenn Chad A , Battiste James D , Sughrue Michael E 
Published: September 2018

ABSTRACT
The inferior fronto-occipital fasciculus (IFOF) is a large white matter tract of the human cerebrum with functional connectivity associated with semantic language processing and goal-oriented behavior. However, little is known regarding the overall connectivity of this tract. Recently, the Human Connectome Project parcellated the human cortex into 180 distinct regions. In our other work, we have shown these various regions in relation to clinically applicable anatomy and function. Utilizing Diffusion Spectrum Magnetic Resonance Imaging tractography coupled with the human cortex parcellation data presented earlier in this supplement, we aim to describe the macro-connectome of the IFOF in relation to the linked parcellations present within the human cortex. The purpose of this study is to present this information in an indexed, illustrated, and tractographically aided series of figures and tables for anatomic and clinical reference.