bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐Inflammatory and Bacteriostatic Effects of Hydrogen‐Rich Water on Rats With Periodontitis
Authors: Bai Yang , Zhao Lisheng , Wang Lin , Shan Yanbo , Zhang Wei , Wen Ning 
Published: November 2024

Objective: To investigate the anti‐inflammatory and bacteriostatic effects of hydrogen‐rich water (HRW) intake on Wistar rats with periodontitis.Methods: The periodontitis model of rats was established by silk ligature and Porphyromonas gingivalis (Pg) solution smearing. The rats were divided into normal control group, model group, and HRW group. The rats in normal control group were given normal feeding without any intervention, while periodontitis was induced in the rats of model group and HRW group, and the rats were given HRW intake and normal saline, respectively, during the whole procedure of the experiments. The antibacterial effect and clinical symptoms (plaque index and gingival sulcus bleeding index (SBI)) were then observed, and peripheral blood (PB), gingival sulcus fluid, and jaw samples were collected to evaluate the changes of inflammatory factors and the curative effect.Results: In the rats of model group, alveolar bone resorption was obvious, which indicated that the rats with periodontitis were successfully constructed, and HRW intake mitigated it. Pg colony number of the rats fed with HRW was significantly lower than that of the model rats. The contents of proinflammatory factors tumor necrosis factor alpha (TNF‐α), interleukin‐1 beta (IL‐1β), and interleukin‐6 (IL‐6) in PB serum and gingival crevicular fluid (GCF) of rats in model group were significantly increased, and HRW intake reversed these and promoted the level of anti‐inflammatory factor interleukin‐10 (IL‐10).Conclusion: HRW can effectively inhibit the growth of periodontal pathogens and reduce inflammation and may be used to prevent or ameliorate periodontitis.
Predictive Value of IL‐6 and Lymphocyte Subsets for Death in Children With Influenza‐Associated Encephalopathy A Retrospective Study
Authors: Sun Ruiyang , Zhang Xue , Hou Jiapu , Jia Wanyu , Li Peng , Wang Daobin , Fu Shuqin , Song Chunlan 
Published: November 2024

Objective: This study aims to investigate the predictive value of interleukin‐6 (IL‐6) and lymphocyte subsets for death in children with influenza‐associated encephalopathy (IAE).Patients: This study included 76 children with IAE who were divided into a death group and a survival group. The differences in the levels of IL‐6 and lymphocyte subsets between the two groups were analyzed, and the predictive value of these two parameters was compared by receiver operating characteristic (ROC) curve analysis.Results: The level of IL‐6 and the percentage of natural killer (NK) cells in the death group were higher than those in the survival group (p  < 0.05). The percentage of CD4+ T cells and CD4+/CD8+ levels in the death group were lower than those in the survival group. ROC curves were used for analysis, and the area under the curves (AUCs) of IL‐6, the percentage of CD4+ T cells, the percentage of CD4+/CD8+, and the percentage of NK cells were 0.812, 0.810, 0.740, and 0.706, respectively. The AUC of the combination of these four metrics was 0.870. There was a little difference in the efficacy of the four clinical indicators, and the predictive efficacy of the combined test was higher than that of the single test.Conclusion: The IL‐6 concentration, percentage of CD4+ T cells, percentage of NK cells, and CD4+/CD8+ have predictive value for death in children with IAE, and the combination of these four metrics has improved the predictive value.
Predictors of Jordanian Registered Nurses’ Clinical Decision‐Making: The Role of Self‐Directed Learning and Personal Characteristics
Authors: Rababah Jehad A. , Al-Hammouri Mohammed Munther 
Published: November 2024

Background: Making clinical decisions is a complex process that encompasses assessing patient needs, identifying potential health problems, and developing and implementing appropriate interventions. The predictors of clinical decision‐making among registered nurses are not thoroughly understood.Aim: To investigate the potential predictors of clinical decision‐making in Jordanian registered nurses. Those predictors included age, gender, percent grade, experience, work hours per week, self‐initiated reading hours per week, and the four dimensions of self‐directed learning: learning motivation, planning and execution, self‐monitoring, and interpersonal relationships.Methods: The authors employed a cross‐sectional design. Registered nurses (N = 139) were recruited from a referral hospital in Jordan. A demographics questionnaire was used in this study. In addition, the nurse decision‐making instrument‐revised and the self‐directed learning instrument were used. Data were collected in August and September 2022. Data analysis was performed using Pearson’s r and multiple linear regression.Results: The results showed that registered nurses’ scores on nurse decision‐making instrument‐revised had positive correlations with age, experience, and self‐directed learning instrument scores. Multiple linear regression results revealed that the model was significant, and the explained variance of registered nurses’ clinical decision‐making was 53%. The following predictors significantly contributed to the regression model: registered nurses’ age, gender, percent grade, experience, and the four domains of self‐directed learning.Conclusion: There is a positive, moderate correlation between registered nurses’ self‐directed learning and clinical decision‐making. This study also showed that registered nurses’ clinical decision‐making is predicted by self‐directed learning and other factors including age, experience, and percent grades.
Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma
Authors: McGeary Meaghan K. , Damsky William , Daniels Andrew J. , Lang Sabine M. , Xu Qingji , Song Eric , Huet-Calderwood Clotilde , Lou Hua Jane , Paradkar Sateja , Micevic Goran , Kaech Susan M. , Calderwood David A. , Turk Benjamin E. , Yan Qin , Iwasaki Akiko , Bosenberg Marcus W. 
Published: November 2024

Abstract
Despite recent advances in the treatment of melanoma, many patients with metastatic disease still succumb to their disease. To identify tumor-intrinsic modulators of immunity to melanoma, we performed a whole-genome CRISPR screen in melanoma and identified Setdb1 as well as all components of the human silencing hub complex. We found that loss of Setdb1 leads to increased immunogenicity and complete tumor clearance in a CD8+ T cell–dependent manner. Mechanistically, loss of Setdb1 causes de-repression of endogenous retroviruses (ERV) in melanoma cells and triggers tumor cell–intrinsic type I IFN signaling, upregulation of MHC-I expression, and increased CD8+ T-cell infiltration. Importantly, spontaneous immune clearance observed in Setdb1−/− tumors results in subsequent protection from other ERV-expressing tumor lines, supporting the functional antitumor role of ERV-specific CD8+ T cells found in the Setdb1−/− microenvironment. Blocking the type I IFN receptor in mice grafted with Setdb1−/− tumors decreases immunogenicity by decreasing MHC-I expression, leading to decreased T-cell infiltration and increased melanoma growth, comparable with Setdb1wt tumors. Together, these results provide key in vivo evidence of a critical role for Setdb1 and type I IFNs in generating an inflamed tumor microenvironment and potentiating tumor cell–intrinsic immunogenicity in melanoma. This study further emphasizes regulators of ERV expression and type I IFN expression as potential therapeutic targets for augmenting anticancer immune responses.
Beyond HRD Status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer
Authors: Kjeldsen Maj K. , Jørgensen Morten , Grønseth Dina Sofie B. , Schønemann-Lund Martin , Nyvang Gitte-Bettina , Haslund Charlotte Aaquist , Knudsen Anja Oer , Motavaf Anne Krejbjerg , Malander Susanne , Anttila Maarit , Lindahl Gabriel , Mäenpää Johanna , Dimoula Maria , Werner Theresa L. , Iversen Trine Zeeberg , Hietanen Sakari , Fokdal Lars , Dahlstrand Hanna , Bjørge Line , Birrer Michael J. , Mirza Mansoor R. , Rossing Maria 
Published: November 2024

Abstract
The management of advanced epithelial ovarian cancer (AOC) has undergone significant advancements with the emergence of molecular diagnostics, particularly in predicting responses to PARP inhibitors (PARPi) based on homologous recombination deficiency (HRD) status. However, understanding sensitivity and resistance beyond HRD status remains elusive. This study aims to explore molecular factors that may elucidate why HRD status does not consistently predict PARPi sensitivity. Therefore, we conducted a post hoc translational analysis of formalin-fixed paraffin-embedded tumor samples from the ENGOT-ov24/NSGO-AVANOVA part 1 and 2 trial (NCT02354131), focusing on alterations pertaining radiologic response and progression-free survival (PFS). DNA sequencing was performed using the TruSight Oncology 500 HT gene panel, with variants classified according to recent guidelines. HRD status had been assessed by Myriad MyChoice CDx. We identified, among 92 patients in the ENGOT-ov24/NSGO-AVANOVA part 1 and 2 trial, 151 pathogenic or likely pathogenic variants across 81 samples. PARPi-sensitizing variants were found in two out of 10 HRD-negative samples from patients with clinical benefit (PFS ≥12 months), whereas three out of 10 HRD-positive samples from patients having no benefit (PFS ≤6 months) harbored variants associated with PARPi resistance. Additionally, analysis of BRCA1 variants revealed that truncating variants in exon 11 correlated with clinical benefit when niraparib was combined with bevacizumab. Conclusively, our findings highlight the complexity of PARPi response in AOC and underscore the importance of exploring somatic variants beyond HRD status. Further investigation into exon 11 variants of BRCA1 and the potential of combination treatment is warranted.

Significance:
The irregular response to PARPi in HRD-positive and -negative tumors highlights the need for identifying additional biomarkers. This study explores the mutational landscape beyond HRD status in AOC, ultimately advancing precision oncology in future clinical practice.
Early Jewish Perspectives on Travel(ling) Texts and Transformation
Authors: Uusimäki Elisa , Høgenhaven Jesper 
Published: November 2024

Abstract
This introductory article explores the rise of travel as an area of research within the field of biblical studies. It first discusses some major trends in the study of travel in the ancient Jewish tradition, including travel as a literary motif in biblical narrative and the evidence for travel in the context of early Judaism. While the significance of travel as a topic of research has been established in biblical studies, more work remains to be done regarding various aspects of the topic, including non-human travellers and the experience and effects of travel. Travel is not just about geographical relocations, as the selected focus on travel and transformation also seeks to emphasize. Drawing on related discussions in literary studies, the article then discusses travel as a practice that requires transitions which take people into liminal spaces and lead to potentially transformative outcomes. Finally, it explains how the articles included in the thematic issue add to this conversation from different yet complementary angles. They primarily focus on travel as a literary motif in various early Jewish corpora but also consider later and contemporary travel of ancient fragments, highlighting how travel may shape and change those on the move in different ways.
Peurbach’s Precursors
Authors: Nothaft C. Philipp E. 
Published: November 2024

Abstract
The idea of reconciling Ptolemaic planetary theory with Aristotelian natural philosophy by imagining epicycles and eccentric deferents as three-dimensional orbs or orb-segments within larger spheres is frequently associated with Georg Peurbach and his widely read astronomy textbook, the Theoricae novae planetarum (1454). This article cautions against existing tendencies to overstate the originality or revolutionary force of this work by taking a closer look at the early history of the same Ptolemaic-Aristotelian compromise in a Latin European context. Using previously unpublished or unused source material from the twelfth to early fourteenth centuries, it documents the gradual spread and acceptance of an orbicular interpretation of Ptolemy’s planetary models among astronomers and university teachers.
Morphological and biological characters of the entomophilic stage of Schistonchus pumilae (Aphelenchoididae) with an update of its molecular profiles
Authors: Tanaka Ryusei , Kanzaki Natsumi , Giblin-Davis Robin M. 
Published: November 2024

Summary
Schistonchus pumilae was first reported from the syconi of a creeper fig, Ficus pumila, from Miyazaki, Japan, and the species was described based on propagative (plant-parasitic) females and males. Thus, the premature female (entomophilic form) of the species was not described. In the present study, male syconi of F. pumila were collected from the type locality of the nematode (Miyazaki, Japan), and the premature females of S. pumilae were collected from inside the syconi and also from the emerging pollinator fig wasps (Wiebesia pumilae). Although only 26 female wasps were recovered for dissections, seven of them harboured 1-7 nematodes each. Nematodes associated with the wasp were all premature females, and their typological and morphometric characters were similar with those isolated from inside the syconi. In addition, the premature females were slightly smaller than propagative females and had a less developed gonad, suggesting that the nematode is a phoretic associate, not a parasite. Regardless of its phylogenetic status, the carrier insect usage of S. pumilae is somewhat similar to two Ficophagus species, and clearly different from S. caprifici, which propagates in the host wasp haemocoel as a parasite. Additionally, the molecular profiles of S. pumilae (SSU and D1-D3 LSU of ribosomal RNA genes) were re-sequenced using a cloning technique, and the information was updated for phylogenetic analysis in the future.
Damage thresholds and population dynamics of the root-knot nematode, Meloidogyne javanica, on selected chickpea cultivars from Ethiopia
Authors: Kefelegn Habtamu , Meressa Beira Hailu , Wesemael Wim M.L. , Bert Wim , Teklu Misghina G. 
Published: November 2024

Summary
The root-knot nematode, Meloidogyne javanica, is one of the most damaging plant-parasitic nematodes, affecting chickpea and causing substantial yield losses worldwide. The damage potential and population dynamics of this nematode in chickpea in Ethiopia have yet to be investigated. In this study, six chickpea cultivars were tested using 12 ranges of initial population densities (Pi) of M. javanica second-stage juveniles (J2): 0, 0.125, 0.25, 0.5, 1, 2, 4, 8, 16, 32, 64 and 128 J2 (g dry soil)−1 in a controlled glasshouse pot experiment. The Seinhorst yield loss and population dynamics models were fitted to describe population development and the effect on different measured growth variables. The tolerance limit (TTFW) for total fresh weight ranged from 0.05 to 1.22 J2 (g dry soil)−1, with corresponding yield losses ranging from 31 to 64%. The minimum yield for seed weight (mSW) ranged from 0.29 to 0.61, with estimated yield losses of 71 and 39%. The ‘Haberu’ and ‘Geletu’ cultivars were considered good hosts, with maximum population densities (M) of 16.27 and 5.64 J2 (g dry soil)−1 and maximum multiplication rate (a) values of 6.25 and 9.23, respectively. All other cultivars are moderate hosts for M. javanica; therefore, it is crucial to initiate chickpea-breeding strategies to manage the tropical root-knot nematode M. javanica in Ethiopia.
Artistic Bilingualism in the Greek Poleis of the Northern Black Sea: a Note on the Olbian Kouros in the State Hermitage Museum
Authors: Figura Federico 
Published: November 2024

Abstract
The contact between Greek artistic tradition and that of the local populations in the Northern Black Sea area has traditionally been addressed in oppositional and hierarchical terms, often employing categories determined by ethnic criteria. This trend is not only limited to this specific area, but is a phenomenon that concerns the so-called “frontiers” of the Greek world, such as Magna Graecia and Sicily. By adopting a non-hierarchical perspective, the well-known kouros from the gymnasium of Olbia is here reconsidered as case-study. This object has always puzzled scholars, often leading to rather bizarre interpretations. By contextualizing it in the local panorama and comparing it, in particular, with the kurgan stelae, the hybrid status of this artefact is highlighted, both from a formal, technical, and iconographic point of view. Since this conclusion suits better the archaeological evidence of Archaic Olbia, this analysis ultimately prompts a reconsideration of the materials from the Northern Black Sea poleis according to more flexible paradigms, enabling the dialectical exchange between various languages developing within the same “artistic space”.
Hillforts and Cyclopean Structures of Western Azerbaijan: a Preliminary Analysis
Authors: Castelluccia Manuel , Ashurov Safar 
Published: November 2024

Abstract
The mountain area bordering Mesopotamia witnessed remarkable transformations to the human and cultural landscape starting from the end of the 2nd millennium. Stone hilltop structures began to spread and became the most distinct settlement form. Moreover, there was a dramatic increase in metalworking and weapons production, showing how the local social structure shifted towards militarization of society.
These heavily fortified settlements have usually been labeled as “cyclopean fortresses” due to their similarity to European defensive structures. However, being built with large stones on strategic hilltops, they played different political and economic roles, and some were likely the seat of important local political entities.
Fortresses from the southern Caucasus have attracted the attention of several distinguished scholars and studies, especially structures in present-day Armenia and northern Iran.
This paper aims to present the evidence currently available regarding cyclopean structures in Western Azerbaijan, combining both remote sensing and soviet-era publications. A remarkable culture flourished during the Late Bronze–Early Iron Age in this area, generally known as “Hochdali-Kedabeg”.
« Ce qui seul mérite le nom de style » : Adorno, Beethoven et les bassons de la Cinquième Symphonie
Authors: Kaddour Fériel 
Published: November 2024

Résumé
À la fin de la Cinquième Symphonie de Beethoven, on entend un timbre étrange : un solo de bassons, fortissimo, dans le registre aigu, un effet si incongru qu’on croirait à une faute d’orchestration. Adorno voit là au contraire « ce qui seul mérite le nom de style ». C’est que ce défaut du timbre est révélateur d’un défaut de la dialectique formelle, point crucial qu’Adorno scrute tout au long de son essai sur Beethoven. Il s’agit donc de redéployer cette lecture immanente de la partition, et de replacer le motif « raté » des bassons à l’endroit problématique de la forme beethovénienne (sa réexposition). Il s’agit aussi de retracer comment ce fragment participe d’une réflexion plus ample, de la Dialectique de la raison jusqu’à la Théorie esthétique. Ce double mouvement, musical et théorique, permet de mettre au jour l’originalité d’une théorie critique du style : le style non plus perçu comme un travail sur la langue, mais comme un correctif objectif de la langue sur les formes.
A Jewish Refutation of Samawʾal al-Maghribī’s Ifḥām al-Yahūd
Authors: Adang Camilla , Schmidtke Sabine 
Published: November 2024

Abstract
This article offers a contribution to the study of polemics between Muslims and Jews in the Middle Ages. It presents an annotated translation of the extant fragments of a reply by an unknown Jew to the polemical tract Ifḥām al-Yahūd in which the mathematician Samawʾal al-Maghribī (d. 570/1175), who converted to Islam in 558/1163, virulently attacks his former religion. Samawʾal’s tract had a significant impact both on later Muslim polemicists and on Jewish thinkers, who defended their religion against his strictures. The unique manuscript of the anonymous refutation, written in Judaeo-Arabic, is part of the Firkovitch collection kept at the National Library of Russia in St. Petersburg. It is included in a codex that also contains an incomplete version, in the same hand, of Samawʾal al-Maghribī’s tract. While the codex can be tentatively dated to the fourteenth century and was presumably written in Egypt, we cannot know with any degree of certainty when and where the refutation itself was composed, nor whether the unknown author had access to a complete copy of Samawʾal’s work. Although at times the author quotes Ifḥām al-Yahūd verbatim, paraphrases and indirect references to Samawʾal’s arguments are more common. In order to contextualize the unknown author’s counterarguments, we provide a running commentary, including quotations of the passages from Ifḥām al-Yahūd that are being refuted.
The Meaning of the Milk Tea Protests
Authors: Matijasevich David 
Published: November 2024

Abstract
Since the Global Financial Crisis of 2008, the world has witnessed an era of protest. Nearly every corner of the globe has been impacted by protest diffusion. East and Southeast Asia have been no different, with recent pro-democracy revolts and movements in Thailand (2020) and Myanmar (2021–present) having been partially inspired by mass pro-democracy protests in Hong Kong (2014 and 2019) and Taiwan (2014). The virtual alliance that sprouted between protesters and activists across these polities was dubbed the Milk Tea Alliance. This article takes a comparative approach and explores the commonalities of the protests and their participants across the four locales. It argues that the shared political experiences and developments run much deeper than the hashtag alliance and therefore should be understood as part of a transformative regional protest wave that requires further exploration.