bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping child growth failure in Africa between 2000 and 2015
Authors: Osgood-Zimmerman Aaron , Millear Anoushka I. , Stubbs Rebecca W. , Shields Chloe , Pickering Brandon V. , Earl Lucas , Graetz Nicholas , Kinyoki Damaris K. , Ray Sarah E. , Bhatt Samir , Browne Annie J. , Burstein Roy , Cameron Ewan , Casey Daniel C. , Deshpande Aniruddha , Fullman Nancy , Gething Peter W. , Gibson Harry S. , Henry Nathaniel J. , Herrero Mario , Krause L. Kendall , Letourneau Ian D. , Levine Aubrey J. , Liu Patrick Y. , Longbottom Joshua , Mayala Benjamin K. , Mosser Jonathan F. , Noor Abdisalan M. , Pigott David M. , Piwoz Ellen G. , Rao Puja , Rawat Rahul , Reiner Robert C. , Smith David L. , Weiss Daniel J. , Wiens Kirsten E. , Mokdad Ali H. , Lim Stephen S. , Murray Christopher J. L. , Kassebaum Nicholas J. , Hay Simon I. 
Published: February 2018

Abstract
Insufficient growth during childhood is associated with poor health outcomes and an increased risk of death. Between 2000 and 2015, nearly all African countries demonstrated improvements for children under 5 years old for stunting, wasting, and underweight, the core components of child growth failure. Here we show that striking subnational heterogeneity in levels and trends of child growth remains. If current rates of progress are sustained, many areas of Africa will meet the World Health Organization Global Targets 2025 to improve maternal, infant and young child nutrition, but high levels of growth failure will persist across the Sahel. At these rates, much, if not all of the continent will fail to meet the Sustainable Development Goal target—to end malnutrition by 2030. Geospatial estimates of child growth failure provide a baseline for measuring progress as well as a precision public health platform to target interventions to those populations with the greatest need, in order to reduce health disparities and accelerate progress.
Uncovering the balance of forces driving microtubule aster migration in C. elegans zygotes
Authors: De Simone A. , Spahr A. , Busso C. , Gönczy P. 
Published: February 2018

AbstractMicrotubule asters must be positioned precisely within cells. How forces generated by molecular motors such as dynein are integrated in space and time to enable such positioning remains unclear. In particular, whereas aster movements depend on the drag caused by cytoplasm viscosity, in vivo drag measurements are lacking, precluding a thorough understanding of the mechanisms governing aster positioning. Here, we investigate this fundamental question during the migration of asters and pronuclei in C. elegans zygotes, a process essential for the mixing of parental genomes. Detailed quantification of these movements using the female pronucleus as an in vivo probe establish that the drag coefficient of the male-asters complex is approximately five times that of the female pronucleus. Further analysis of embryos lacking cortical dynein, the connection between asters and male pronucleus, or the male pronucleus altogether, uncovers the balance of dynein-driven forces that accurately position microtubule asters in C. elegans zygotes.
Time-dependent in situ measurement of atmospheric corrosion rates of duplex stainless steel wires
Authors: Örnek Cem , Léonard Fabien , McDonald Samuel A. , Prajapati Anuj , Withers Philip J. , Engelberg Dirk L. 
Published: February 2018

AbstractCorrosion rates of strained grade UNS S32202 (2202) and UNS S32205 (2205) duplex stainless steel wires have been measured, in situ, using time-lapse X-ray computed tomography. Exposures to chloride-containing (MgCl2) atmospheric environments at 50 °C (12–15 M Cl− and pH ~5) with different mechanical elastic and elastic/plastic loads were carried out over a period of 21 months. The corrosion rates for grade 2202 increased over time, showing selective dissolution with shallow corrosion sites, coalescing along the surface of the wire. Corrosion rates of grade 2205 decreased over time, showing both selective and pitting corrosion with more localised attack, growing preferentially in depth. The nucleation of stress corrosion cracking was observed in both wires.
In situ electrochemical dissolution of platinum and gold in organic-based solvent
Authors: Jovanovič Primož , Šelih Vid Simon , Šala Martin , Hodnik Nejc 
Published: February 2018

AbstractIn situ highly sensitive potential- and time-resolved monitoring of polycrystalline gold and platinum electrochemical dissolution in pure organic media is reported. This was achieved by successfully upgrading electrochemical flow cell coupled to inductively coupled plasma mass spectrometry. Similar to the aqueous media, aggressive transient dissolution takes place during oxide formation and reduction. In contrary to the aqueous electrolyte, both gold and platinum exhibit enhanced anodic compared to the cathodic oxide-assisted dissolution in organic media. This study intends to highlight the capabilities of the new methodology, which will expand the studies of metals dissolution to the fields like organic electrocatalysis, corrosion, battery research, and sensors among others.
Broadband multiresonator quantum memory-interface
Authors: Moiseev S. A. , Gerasimov K. I. , Latypov R. R. , Perminov N. S. , Petrovnin K. V. , Sherstyukov O. N. 
Published: February 2018

AbstractIn this paper we experimentally demonstrated a broadband scheme of the multiresonator quantum memory-interface. The microwave photonic scheme consists of the system of mini-resonators strongly interacting with a common broadband resonator coupled with the external waveguide. We have implemented the impedance matched quantum storage in this scheme via controllable tuning of the mini-resonator frequencies and coupling of the common resonator with the external waveguide. Proof-of-principal experiment has been demonstrated for broadband microwave pulses when the quantum efficiency of 16.3% was achieved at room temperature. By using the obtained experimental spectroscopic data, the dynamics of the signal retrieval has been simulated and promising results were found for high-Q mini-resonators in microwave and optical frequency ranges. The results pave the way for the experimental implementation of broadband quantum memory-interface with quite high efficiency η > 0.99 on the basis of modern technologies, including optical quantum memory at room temperature.
Microbead-based spoligotyping of Mycobacterium tuberculosis from Ziehl-Neelsen-stained microscopy preparations in Ethiopia
Authors: Molina-Moya Barbara , Agonafir Mulualem , Blanco Silvia , Dacombe Russell , Gomgnimbou Michel K. , Spinasse Lizania , Gomes-Fernandes Meissiner , Datiko Daniel G. , Edwards Thomas , Cuevas Luis E. , Dominguez Jose , Sola Christophe 
Published: February 2018

AbstractThe worldwide dissemination of Mycobacterium tuberculosis strains has led to the study of their genetic diversity. One of the most used genotyping methods is spoligotyping, based on the detection of spacers in the clustered regularly interspaced short palindromic repeats (CRISPR) locus. This study assessed the performance of a microbead-based spoligotyping assay using samples extracted from Ziehl-Neelsen-stained smear-microscopy preparations and described the genetic diversity of Mycobacterium tuberculosis among new TB patients in Southern Nations, Nationalities and Peoples’ Region (SNNPR) in Ethiopia. Among the 91 samples analysed, 59 (64.8%) generated spoligotyping patterns. Fifty (84.7%) samples were classified into 12 clusters (mostly Lineage 4 or 3) comprising 2–11 samples and nine had unique spoligotyping patterns. Among the 59 spoligotyping patterns, 25 belonged to the T1 sublineage, 11 to the T3-ETH, 5 to the URAL, 4 to the H3 and 14 to other L4 sublineages. There was a remarkable variation in genetic distribution in SNNPR compared to other regions of the country. Microbead-based spoligotyping is an easy-to-perform, high-throughput assay that can generate genotyping information using material obtained from smear microscopy preparations. The method provides an opportunity to obtain data of the M. tuberculosis genetic epidemiology in settings with limited laboratory resources.
Efficient detection of Zika virus RNA in patients’ blood from the 2016 outbreak in Campinas, Brazil
Authors: Judice Carla Cristina , Tan Jeslin J. L. , Parise Pierina Lorencini , Kam Yiu-Wing , Milanez Guilherme Paier , Leite Juliana Almeida , Caserta Leonardo Cardia , Arns Clarice Weis , Resende Mariangela Ribeiro , Angerami Rodrigo , Amaral Eliana , Junior Renato Passini , Freitas André Ricardo Ribas , Costa Fabio Trindade Maranhão , Proenca-Modena Jose Luiz , Ng Lisa F. P. ,   The Zika-Unicamp Network, Pastore Glaucia Maria , Mayer-Milanez Helaine Maria Besteti Pires , Ribeiro-do-Valle Carolina C. , Calil Roseli , Costa Maria Laura , Junior João Renato Bennini , Lajos Giuliane Jesus , Garcia Márcia Teixeira , Fertrin Kleber Yotsumoto , Moretti Maria Luiza , da Silva Marcos Tadeu Nolasco , Coan Ana Carolina , Colella-Santos Maria Francisca , von Zuben Andrea Paula Bruno , Vinolo Marco Aurélio Ramirez , Catharino Rodrigo Ramos , do Nascimento Gabriela Mansano , Martini Matheus , de Moraes Ana Paula , Soledade Ana Lucia Rodrigues , de Toledo Teixeira Daniel Augusto , de Morais Évellyn Ribeiro , Santos Felipe Rebelo , Fontana Monique 
Published: February 2018

AbstractInfection with Zika virus (ZIKV), a mosquito-borne flavivirus has been casually linked with increased congenital microcephaly in Brazil from 2015 through 2016. Sensitive and specific diagnosis of patients with Zika fever (ZIKF) remains critical for patient management. We developed a ZIKV NS5 qRT-PCR assay by combining primers described by Balm et al. and a new Taqman probe. The assay was evaluated and compared with another assay described by Lanciotti et al. (ZIKV 1107) using 51 blood and 42 urine samples from 54 suspected ZIKV patients. ZIKV NS5 performed better in terms of sensitivity with more samples detected as ZIKV-positive (n = 37) than ZIKV 1107 (n = 34) for urine, and ZIKV-positive (n = 29) than ZIKV 1107 (n = 26) for blood. Both assays displayed good overall agreement for urine (κappa = 0.770) and blood (κappa = 0.825) samples. Improved availability of validated diagnostic tests, such ZIKV NS5 qRT-PCR, will be critical to ensure adequate and accurate ZIKV diagnosis.
Shear Viscosity of Uniform Fermi Gases with Population Imbalance
Authors: Cai Weimin , Guo Hao , He Yan , Chien Chih-Chun 
Published: February 2018

AbstractThe shear viscosity has been an important topic in ultracold Fermi gases, and it has served as a diagnostic of various theories. Due to the complicated phase structures of population-imbalanced (polarized) Fermi gases with tunable attraction, past works on the shear viscosity mainly focused on unpolarized Fermi gases. Here we investigate the shear viscosity of homogeneous, population-imbalanced Fermi superfluid at finite temperatures by a pairing fluctuation theory for thermodynamical quantities and a gauge-invariant linear response theory for transport coefficients. The Cooper pairs lead to the anomalous shear viscosity analogous to the shear viscosity. We derive an exact relation connecting certain thermodynamic quantities and transport coefficients at the mean-field level for polarized unitary Fermi superfluids. An approximate relation beyond mean-field is proposed and only exhibits mild deviations from our numerical results. In the unitary and Bose-Einstein condensation (BEC) regimes, the total shear viscosity increases with the polarization because the excess majority fermions cause gapless excitations acting like a normal fluid. Moreover, competition among the excess fermions, noncondensed pairs, and fermionic quasiparticles may lead to non-monotonic behavior of the ratio between the shear viscosity and relaxation time as the polarization increases.
Radiomics analysis at PET/CT contributes to prognosis of recurrence and survival in lung cancer treated with stereotactic body radiotherapy
Authors: Oikonomou Anastasia , Khalvati Farzad , Tyrrell Pascal N. , Haider Masoom A. , Tarique Usman , Jimenez-Juan Laura , Tjong Michael C. , Poon Ian , Eilaghi Armin , Ehrlich Lisa , Cheung Patrick 
Published: February 2018

AbstractWe sought to quantify contribution of radiomics and SUVmax at PET/CT to predict clinical outcome in lung cancer patients treated with stereotactic body radiotherapy (SBRT). 150 patients with 172 lung cancers, who underwent SBRT were retrospectively included. Radiomics were applied on PET/CT. Principal components (PC) for 42 CT and PET-derived features were examined to determine which ones accounted for most of variability. Survival analysis quantified ability of radiomics and SUVmax to predict outcome. PCs including homogeneity, size, maximum intensity, mean and median gray level, standard deviation, entropy, kurtosis, skewness, morphology and asymmetry were included in prediction models for regional control (RC) [PC4-HR:0.38, p = 0.02], distant control (DC) [PC4-HR:0.51, p = 0.02 and PC1-HR:1.12, p = 0.01], recurrence free probability (RFP) [PC1-HR:1.08, p = 0.04], disease specific survival (DSS) [PC2-HR:1.34, p = 0.03 and PC3-HR:0.64, p = 0.02] and overall survival (OS) [PC4-HR:0.45, p = 0.004 and PC3-HR:0.74, p = 0.02]. In combined analysis with SUVmax, PC1 lost predictive ability over SUVmax for RFP [HR:1.1, p = 0.04] and DC [HR:1.13, p = 0.002], while PC4 remained predictive of DC independent of SUVmax [HR:0.5, p = 0.02]. Radiomics remained the only predictors of OS, DSS and RC. Neither SUVmax nor radiomics predicted recurrence free survival. Radiomics on PET/CT provided complementary information for prediction of control and survival in SBRT-treated lung cancer patients.
Insulin-signalling dysregulation and inflammation is programmed trans-generationally in a female rat model of poor maternal nutrition
Authors: Tarry-Adkins Jane L. , Aiken Catherine E. , Ashmore Thomas J. , Ozanne Susan E. 
Published: February 2018

AbstractDevelopmental programming phenotypes can be recapitulated in subsequent generations not directly exposed to the initial suboptimal intrauterine environment. A maternal low-protein diet during pregnancy and postnatal catch-up growth (‘recuperated’) alters insulin signaling and inflammation in rat offspring (F1-generation). We aimed to establish if this phenotype is also present in F2-generation females. Insulin-receptor-substrate-1 protein expression was decreased in para-ovarian adipose tissue at 3 months in offspring exposed to a grand-maternal low-protein diet (F2-recuperated), vs. F2-control animals (p < 0.05). There was no effect of grand-maternal diet upon Insulin-receptor-substrate-1 mRNA. Protein-kinase C-zeta protein levels were increased at 3 and 6 months in F2-recuperated animals (p < 0.01 at both ages). Phosphorylated-Aktser473 levels were decreased in F2-recuperated animals (p < 0.001). Interleukin-1β protein levels were increased at 3 (p < 0.01) and (p < 0.001) 6 months in F2-recuperated animals. Vastus-lateralis insulin-receptor-β protein expression (p < 0.001) and pAktser473 (p < 0.01) were increased at 3 months in F2-recuperated animals compared to controls. At 6 months, PAktser473 was lower in F2-recuperated animals (p < 0.001). Aspects of insulin signalling dysregulation and inflammation present in offspring of low-protein fed dams can be transmitted to subsequent generations without further exposure to a suboptimal maternal diet. These findings contribute to our understanding of insulin-resistance in grandchildren of sub-optimally nourished individuals during pregnancy.
Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity
Authors: Pasquin Sarah , Chehboun Salma , Dejda Agnieszka , Meliani Yasmine , Savin Virginia , Warner Gregory J. , Bosse Roger , Tormo Aurélie , Mayer Gaétan , Sharma Mukut , Sapieha Przemyslaw , Martel Catherine , Gauchat Jean-François 
Published: February 2018

AbstractThe cytokines CLCF1 and CNTF are ligands for the CNTF receptor and the apolipoprotein E (ApoE) receptor sortilin. Both share structural similarities with the N-terminal domain of ApoE, known to bind CNTF. We therefore evaluated whether ApoE or ApoE-containing lipoproteins interact with CLCF1 and regulate its activity. We observed that CLCF1 forms complexes with the three major isoforms of ApoE in co-immunoprecipitation and proximity assays. FPLC analysis of mouse and human sera mixed with CLCF1 revealed that CLCF1 co-purifies with plasma lipoproteins. Studies with sera from ApoE−/−mice indicate that ApoE is not required for CLCF1-lipoprotein interactions. VLDL- and LDL-CLCF1 binding was confirmed using proximity and ligand blots assays. CLCF1-induced STAT3 phosphorylation was significantly reduced when the cytokine was complexed with VLDL. Physiological relevance of our findings was asserted in a mouse model of oxygen-induced retinopathy, where the beneficial anti-angiogenic properties of CLCF1 were abrogated when co-administrated with VLDL, indicating, that CLCF1 binds purified lipoproteins or lipoproteins in physiological fluids such as serum and behave as a “lipocytokine”. Albeit it is clear that lipoproteins modulate CLCF1 activity, it remains to be determined whether lipoprotein binding directly contributes to its neurotrophic function and its roles in metabolic regulation.
Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors
Authors: Takahashi Toshiya , Kulkarni Nikhil Nitin , Lee Ernest Y , Zhang Ling-juan , Wong Gerard C. L. , Gallo Richard L. 
Published: February 2018

AbstractUnder homeostatic conditions the release of self-RNA from dying cells does not promote inflammation. However, following injury or inflammatory skin diseases such as psoriasis and rosacea, expression of the cathelicidin antimicrobial peptide LL37 breaks tolerance to self-nucleic acids and triggers inflammation. Here we report that LL37 enables keratinocytes and macrophages to recognize self-non-coding U1 RNA by facilitating binding to cell surface scavenger receptors that enable recognition by nucleic acid pattern recognition receptors within the cell. The interaction of LL37 with scavenger receptors was confirmed in human psoriatic skin, and the ability of LL37 to stimulate expression of interleukin-6 and interferon-β1 was dependent on a 3-way binding interaction with scavenger receptors and subsequent clathrin-mediated endocytosis. These results demonstrate that the inflammatory activity of LL37 is mediated by a cell-surface-dependent interaction and provides important new insight into mechanisms that drive auto-inflammatory responses in the skin.
Three dimensional-stacked complementary thin-film transistors using n-type Al:ZnO and p-type NiO thin-film transistors
Authors: Lee Ching-Ting , Chen Chia-Chi , Lee Hsin-Ying 
Published: February 2018

AbstractThe three dimensional inverters were fabricated using novel complementary structure of stacked bottom n-type aluminum-doped zinc oxide (Al:ZnO) thin-film transistor and top p-type nickel oxide (NiO) thin-film transistor. When the inverter operated at the direct voltage (VDD) of 10 V and the input voltage from 0 V to 10 V, the obtained high performances included the output swing of 9.9 V, the high noise margin of 2.7 V, and the low noise margin of 2.2 V. Furthermore, the high performances of unskenwed inverter were demonstrated by using the novel complementary structure of the stacked n-type Al:ZnO thin-film transistor and p-type nickel oxide (NiO) thin-film transistor.
Mechanical complications and outcomes following invasive emergency procedures in severely injured trauma patients
Authors: Struck Manuel F. , Fakler Johannes K. M. , Bernhard Michael , Busch Thilo , Stumpp Patrick , Hempel Gunther , Beilicke André , Stehr Sebastian N. , Josten Christoph , Wrigge Hermann 
Published: February 2018

AbstractThis study aimes to determine the complication rates, possible risk factors and outcomes of emergency procedures performed during resuscitation of severely injured patients. The medical records of patients with an injury severity score (ISS) >15 admitted to the University Hospital Leipzig from 2010 to 2015 were reviewed. Within the first 24 hours of treatment, 526 patients had an overall mechanical complication rate of 26.2%. Multivariate analysis revealed out-of-hospital airway management (OR 3.140; 95% CI 1.963–5.023; p < 0.001) and ISS (per ISS point: OR 1.024; 95% CI 1.003–1.045; p = 0.027) as independent predictors of any mechanical complications. Airway management complications (13.2%) and central venous catheter complications (11.4%) were associated with ISS >32.5 (p < 0.001) and ISS >33.5 (p = 0.005), respectively. Chest tube complications (15.8%) were associated with out-of-hospital insertion (p = 0.002) and out-of-hospital tracheal intubation (p = 0.033). Arterial line complications (9.4%) were associated with admission serum lactate >4.95 mmol/L (p = 0.001) and base excess <−4.05 mmol/L (p = 0.008). In multivariate analysis, complications were associated with an increased length of stay in the intensive care unit (p = 0.019) but not with 24 hour mortality (p = 0.930). Increasing injury severity may contribute to higher complexity of the individual emergency treatment and is thus associated with higher mechanical complication rates providing potential for further harm.
Datasets2Tools, repository and search engine for bioinformatics datasets, tools and canned analyses
Authors: Torre Denis , Krawczuk Patrycja , Jagodnik Kathleen M. , Lachmann Alexander , Wang Zichen , Wang Lily , Kuleshov Maxim V. , Ma’ayan Avi 
Published: February 2018

AbstractBiomedical data repositories such as the Gene Expression Omnibus (GEO) enable the search and discovery of relevant biomedical digital data objects. Similarly, resources such as OMICtools, index bioinformatics tools that can extract knowledge from these digital data objects. However, systematic access to pre-generated ‘canned’ analyses applied by bioinformatics tools to biomedical digital data objects is currently not available. Datasets2Tools is a repository indexing 31,473 canned bioinformatics analyses applied to 6,431 datasets. The Datasets2Tools repository also contains the indexing of 4,901 published bioinformatics software tools, and all the analyzed datasets. Datasets2Tools enables users to rapidly find datasets, tools, and canned analyses through an intuitive web interface, a Google Chrome extension, and an API. Furthermore, Datasets2Tools provides a platform for contributing canned analyses, datasets, and tools, as well as evaluating these digital objects according to their compliance with the findable, accessible, interoperable, and reusable (FAIR) principles. By incorporating community engagement, Datasets2Tools promotes sharing of digital resources to stimulate the extraction of knowledge from biomedical research data. Datasets2Tools is freely available from: http://amp.pharm.mssm.edu/datasets2tools.