bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review of Wound Infusion With Local Anesthetics in Plastic Surgery
Authors: Roy Catherine F. , Azzi Alain J. , Davison Peter 
Published: June 2019

Background
Suboptimal pain management is a common, yet largely unrecognized, problem in the postsurgical patient population. Current treatment protocols heavily rely on opioid use and, though generally effective in providing pain relief, are associated with multiple side effects. The present systematic review aims to offer plastic surgeons insight into the current state of literature on prolonged local anesthetic wound infusion regimens, evaluating both their efficacy in lowering pain scores and the potential opioid-sparing effect.

Methods
A comprehensive literature search of the Medline, Embase, and Cochrane Library databases was performed to identify relevant studies published between 1980 and December 2017 evaluating the use of prolonged local anesthetic wound infusion for postoperative pain management in plastic surgery.

Results
A total of 28 articles were selected, including 3904 patients. The overall infection rate in all patients treated with postsurgical local anesthetic wound infiltration was 0.28% (7/2536). There were no reported cases of systemic toxicity. An opioid-sparing effect was found in 92% (12/13) of studies when compared to an active comparator and 88% (7/8) of those comparing to placebo. Pain scores were decreased in 90% (9/10) of studies comparing wound infiltration to narcotic-based regimens and in 67% (6/9) of those comparing to placebo.

Conclusions
Continuous or intermittent wound infusion is safe and effective in reducing pain scores and opioid consumption in plastic surgery. Though the overall pain-lowering effect appears to be modest, ease of catheter insertion and patient satisfaction make this technique an alluring alternative to more validated approaches such as neuraxial or peripheral nerve blocks.
Host engineering for improved valerolactam production inPseudomonas putida
Authors: Thompson Mitchell G. , Valencia Luis E. , Blake-Hedges Jacquelyn M. , Cruz-Morales Pablo , Velasquez Alexandria E. , Pearson Allison N. , Sermeno Lauren N. , Sharpless William A. , Benites Veronica T. , Chen Yan , Baidoo Edward E. K. , Petzold Christopher J. , Deutschbauer Adam M. , Keasling Jay D. 
Published: June 2019

ABSTRACTPseudomonas putidais a promising bacterial chassis for metabolic engineering given its ability to metabolize a wide array of carbon sources, especially aromatic compounds derived from lignin. However, this omnivorous metabolism can also be a hindrance when it can naturally metabolize products produced from engineered pathways. Herein we show thatP. putidais able to use valerolactam as a sole carbon source, as well as degrade caprolactam. Lactams represent important nylon precursors, and are produced in quantities exceeding one million tons per year[1]. To better understand this metabolism we use a combination of Random Barcode Transposon Sequencing (RB-TnSeq) and shotgun proteomics to identify theoplBAlocus as the likely responsible amide hydrolase that initiates valerolactam catabolism. Deletion of theoplBAgenes preventedP. putidafrom growing on valerolactam, prevented the degradation of valerolactam in rich media, and dramatically reduced caprolactam degradation under the same conditions. Deletion ofoplBA, as well as pathways that compete for precursors L-lysine or 5-aminovalerate, increased the titer of valerolactam from undetectable after 48 hours of production to ~90 mg/L. This work may serve as a template to rapidly eliminate undesirable metabolism in non-model hosts in future metabolic engineering efforts.
RMetD2: a tool for integration of relative transcriptomics data into Genome-scale metabolic models
Authors: Zhang Cheng , Lee Sunjae , Bidkhori Gholamreza , Benfeitas Rui , Lovric Alen , Chen Shuqi , Uhlen Mathias , Nielsen Jens , Mardinoglu Adil 
Published: June 2019

AbstractRelative Metabolic Differences version 2 (RMetD2) is a tool for integration of differentially expressed (DE) genes into genome-scale metabolic models (GEMs) for revealing the altered metabolism between two biological conditions. This method provides a robust evaluation of the metabolism by using flux ranges instead of a single set of flux distributions. RMetD2 classifies reactions into three different groups, namely up-regulated, down-regulated and unchanged, which enables systematic interpretation of the metabolic differences between two different conditions. We employed this method in three different case studies using mice and human datasets, and compared it with state-of-the-art methods used for studying condition-specific metabolic differences using GEMs. We observed that RMetD2 is capable of capturing experimentally-observed features that are missed by other methods, highlighting its potential use in biotechnology and systems medicine applications. RMetD2 is implemented in Matlab and it is available without any limitation at https://sourceforge.net/projects/rmetd.
GABAergic cell loss in mice lacking autism-associated geneSema6A
Authors: Menzel Karlie , Szabó Gábor , Yanagawa Yuchio , Cocksaygan Turhan , Plachez Céline 
Published: June 2019

AbstractBackgroundDuring brain development, a multitude of neuronal networks form as neurons find their correct position within the brain and send out axons to synapse onto specific targets. Altered neuronal connectivity within these complex networks has been reported in Autism Spectrum Disorder (ASD), leading to alterations in brain function and multisensory integration. Semaphorins (also referred to as Semas), a large protein family of about 30 members, have been shown to play an important role in neuronal circuit formation and have been implicated in the etiology of ASD. The purpose of the current study is to investigate howSema6Amutation affects neuronal connectivity in ASD. SinceSema6Ais involved in cell migration, we hypothesized that during brain development the migration of GABAergic interneurons is affected by the loss ofSema6Agene, leading to alterations in Excitatory/Inhibitory (E/I) balance.MethodsSema6Atransgenic mice were crossed with either GAD65-GFP mice or GAD67-GFP mice to allow for both a reliable and robust staining of the GABAergic interneuron population within theSema6Amouse line. Using histological techniques we studies the expression of interneurons subtypes in the Sema6A mutant mice.ResultsAnalysis ofSema6Amutant mice crossed with either GAD65-GFP or GAD67-GFP knock-in mice revealed a reduced number of GABAergic interneurons in the primary somatosensory cortex, hippocampus, and reticular thalamic nucleus (RTN) in adultSema6Amutant mice. This reduction in cell number appeared to be targeted to the Parvalbumin (PV) interneuron cell population since neither the Calretinin nor the Calbindin expressing interneurons were affected by theSema6Amutation.LimitationsAlthough the use of animal models has been crucial for understanding the biological basis of autism, the complexity of the human brain can never truly be replicated by these models.ConclusionsTaken together, these findings suggest thatSema6Agene loss affects only the fast spiking-PV population and reveal the importance of an axon guidance molecule in the formation of GABAergic neuronal networks and provide insight into the molecular pathways that may lead to altered neuronal connectivity and E/I imbalance in ASD.
Employees’ customer orientation and customer satisfaction in the public utility sector
Authors: Li Wenyuan , Pomegbe Wisdom Wise Kwabla , Dogbe Courage Simon Kofi , Novixoxo Jewel Dela 
Published: June 2019

Purpose
The purpose of this paper is to ascertain how perceived service quality mediates employees’ customer orientation and customer satisfaction in the public utility sector.

Design/methodology/approach
The study focused on the commercial customers (small and medium-scale enterprises– (SMEs)) of Electricity Company of Ghana Ltd. There were 350 SMEs sampled for the study, and each had no more than 99 employees. Respondents were either owner-managers or employee-managers. Structural equation model (SEM) was used in estimating the effects among the variables studied.

Findings
Most public institutions have a built-in customer base, and therefore places less emphasis on employees’ customer orientation. This notwithstanding, findings revealed that employees’ customer orientation behaviors significantly impacted customers’ perceived service quality and satisfaction toward public institutions. Similarly, customers’ perceived service quality influenced their satisfaction toward public institutions. SMEs serve as an engine for economic growth in an economy, and therefore public institutions must consider their peculiar needs in the delivery of service to them.

Originality/value
This study pointed out that, employees’ customer orientation behaviors of public institutions have an influence on customers’ perceived service quality and satisfaction. Previous studies on these concepts have largely focused on the private sector, where there are lots of competition. This study also specifically studied commercial customers (SMEs) of public institution, which is quite novel, especially in relation to the concepts studied. And the contribution of SMEs to economic growth makes their study even much more important.
Ibn Khaldun’s ‘ilm al ‘umran: a model for planning the sustainable city in the Arab region
Authors: El-Kholei Ahmed O. 
Published: June 2019

Purpose
Sustainable development is an attempt to achieve three competing aims: economic development, social justice and environmental conservation. Localising sustainable development in the Arabian city might require a framework that originates from its reality manifested in the region’s history, culture and religion. Ibn Khaldun’s model seems suitable for planning a sustainable city in the Arab world. The purpose of this paper is to discuss suitability of Ibn Khaldun’s writing to localising sustainable development in the Arabian cities.

Design/methodology/approach
The paper used a qualitative research methodology. The researcher investigated the writings of Ibn Khaldun and other scholars who studied his work to derive lessons for planning the sustainable Arab city.

Findings
Many of Ibn Khaldun’s concepts lost their accuracy, meanings and intentions in the course of translating his work. Ibn Khaldun’s writings can be the source from which scholars, planners and city administrators derive lessons to assure the sustainable development of human settlements, particularly in the Arab region. The writings of Ibn Khaldun are relevant to the Arab countries. His writings are sensitive to the realities of the Arab world, including geography, environment, history, religion and culture. His writings can support efforts for localising sustinable development in the Arabian cities.

Originality/value
Interrogating Ibn Khaldun’s writings can enable scholars, planners, architects and city administrators to elaborate and implement plans for the sustainable Arabian city. The findings of the paper assure that Ibn Khaldun’s analysis is suitable for addressing the urban ills of the contemporary Arabian metropolis as they were in his time.
The interplay of external ties and internal knowledge base
Authors: Ye Jiangfeng , Wu Yunqiao , Hao Bin , Chen Zusheng 
Published: June 2019

PurposeThe purpose of this study is to investigate the relationships between two types of informal ties and radical innovation in the context of China’s university spin-offs and the moderating roles of knowledge breadth and depth in such relationships.Design/methodology/approachA systematic review of literature on informal ties, internal knowledge base and radical innovation provides the theoretical foundation of the research framework and hypotheses. Using a sample of 158 China’s university spin-offs, the authors conduct a regression analysis on the theoretical framework and hypotheses.FindingsThe results show that business and university ties are positively related to radical innovation. Moreover, the effects of business and university ties on radical innovation are contingent on knowledge breadth and depth in opposite ways. In particular, the positive effect of business ties on radical innovation depends significantly on internal knowledge depth rather than on knowledge breadth, and the positive effect of university ties on radical innovation will be affected by internal knowledge breadth rather than knowledge depth.Practical implicationsManagers of university spin-offs must examine informal ties they already have and identify their nature, content and embedded advantages and promptly adjust their strategy of informal ties to adapt to their firms’ internal knowledge base.Originality/valueThis study highlights the positive role of managers’ personal connections with different external parties in facilitating radical innovation and advances the understanding of informal ties by proposing that the effects of informal ties on radical innovation are contingent on a firm’s internal knowledge base in the context of China’s university spin-offs.
Photonic curing of silver paths on 3D printed polymer substrate
Authors: Krzeminski Jakub , Blicharz Bartosz , Skalski Andrzej , Wroblewski Grzegorz , Jakubowska Małgorzata , Sloma Marcin 
Published: June 2019

Purpose
Despite almost limitless possibilities of rapid prototyping, the idea of 3D printed fully functional electronic device still has not been fulfilled – the missing point is a highly conductive material suitable for this technique. The purpose of this paper is to present the usage of the photonic curing process for sintering highly conductive paths printed on the polymer substrate.

Design/methodology/approach
This paper evaluates two photonic curing processes for the conductive network formulation during the additive manufacturing process. Along with the xenon flash sintering for aerosol jet-printed paths, this paper examines rapid infrared sintering for thick-film and direct write techniques.

Findings
This paper proves that the combination of fused deposition modeling, aerosol jet printing or paste deposition, along with photonic sintering, is suitable to obtain elements with low resistivity of 3,75·10−8 Ωm. Presented outcomes suggest the solution for fabrication of the structural electronics systems for daily-use applications.

Originality/value
The combination of fused deposition modelling (FDM) and aerosol jet printing or paste deposition used with photonic sintering process can fill the missing point for highly conductive materials for structural electronics.
Predicting drug–disease associations by network embedding and biomedical data integration
Authors: Wei Xiaomei , Zhang Yaliang , Huang Yu , Fang Yaping 
Published: June 2019

PurposeThe traditional drug development process is costly, time consuming and risky. Using computational methods to discover drug repositioning opportunities is a promising and efficient strategy in the era of big data. The explosive growth of large-scale genomic, phenotypic data and all kinds of “omics” data brings opportunities for developing new computational drug repositioning methods based on big data. The paper aims to discuss this issue.Design/methodology/approachHere, a new computational strategy is proposed for inferring drug–disease associations from rich biomedical resources toward drug repositioning. First, the network embedding (NE) algorithm is adopted to learn the latent feature representation of drugs from multiple biomedical resources. Furthermore, on the basis of the latent vectors of drugs from the NE module, a binary support vector machine classifier is trained to divide unknown drug–disease pairs into positive and negative instances. Finally, this model is validated on a well-established drug–disease association data set with tenfold cross-validation.FindingsThis model obtains the performance of an area under the receiver operating characteristic curve of 90.3 percent, which is comparable to those of similar systems. The authors also analyze the performance of the model and validate its effect on predicting the new indications of old drugs.Originality/valueThis study shows that the authors’ method is predictive, identifying novel drug–disease interactions for drug discovery. The new feature learning methods also positively contribute to the heterogeneous data integration.
LBM modelling unsteady flow past and through permeable diamond-shaped cylinders
Authors: Zhang Yingchun , Ozalp Nesrin , Xie Gongnan 
Published: June 2019

Purpose
The purpose of this paper is to investigate the unsteady flow past through a permeable diamond-shaped cylinder and to study the effects of the aspect ratios and Darcy numbers of the cylinder.

Design/methodology/approach
The lattice Boltzmann method with D2Q9 lattice model was used to simulate the unsteady flow through permeable diamond-shaped cylinders. The present numerical method is validated against the available data.

Findings
The key findings are that increasing the permeability enhances the suppression of vortex shedding, and that the Strouhal number is directly proportion to the Darcy number, Reynolds number and the aspect ratio of the porous cylinder.

Originality/value
The present study considers unsteady laminar flow past through single permeable diamond-shaped cylinder. According to the authors’ knowledge, very few studies have been found in this field. The present findings are novel and original, which in turn can attract wide attention and citations.
Gentrification, touristification and revitalization of the Monumental Zone of Pontevedra, Spain
Authors: Torres Outón Sara María 
Published: June 2019

PurposeThe purpose of this paper is to explore, through the analysis case, how the revitalization of a historic centre has been carried out and the role of tourism in this process.Design/methodology/approachThis case study area is well-documented as there has been extensive fieldwork on the transformation of the commercial sector in the Monumental Zone of Pontevedra in the last three decades. In order to prepare this paper, a bibliographic review, in-depth interviews, premises registration data and population data have been used.FindingsThe findings show that the processes of change and revitalization do not conform to a single reality common to all historical centres, although similar strategies are developed, the role of the participating actors and, especially, the idiosyncrasy of these spaces change the outcomes. On the one hand, gentrification does not occur and the increase of residential uses is still a goal. On the other hand, the tourism strategy brings more visitors and complements the commerce activity and attraction.Social implicationsThe new challenge of these spaces, and the urban contribution from this research, is that in the appropriation of space by citizens, tourism may be a complement for commerce, and shops and hospitality (facilities) make these spaces more livable. Although tourism does not necessarily increase the number of residents, the revenue from tourism may prevent the reoccurrence of abandonment.Originality/valueThe paper focusses on both gentrification and touristification; processes that have led to the substitution of residents and activities and the conflict with the local population and the normalization of urban life. This case has been selected because despite a seemingly successful revitalization process, recently some old threats seem to be returning.
Online shopping environments and consumer’s Need for Touch
Authors: Rathee Rupa , Rajain Pallavi 
Published: June 2019

Purpose
Online shopping has become a commonplace thing nowadays as people can buy products from the comfort of their home. But such environments do not offer a complete sensory interaction as consumers are unable to touch products which is quite important for certain categories of products such as apparels. Therefore, in order to find whether every individual seeks touch equally, the purpose of this paper is to deal with the differences in an individual’s preferences for touch. The study also evaluates customer responses towards the introduction of touch-enabling technology which can, to some extent, compensate for the lack of touch. Lastly, the study includes customers’ views regarding showrooming and webrooming.

Design/methodology/approach
A total of 203 responses were received through online and offline questionnaires. The data were analysed using ANOVA, correlation and regression analysis through SPSS version 23.

Findings
The results revealed that gender influenced the Need for Touch (NFT) with women having higher NFT. The people who were high in NFT preferred to buy in-store, whereas their low NFT counterparts were comfortable with both online and in-store options. Lastly, it was found that there was a significant impact of NFT on online buying behaviour. The new technology when used by online retailers would break the barriers that exist between real touch and virtual touch.

Originality/value
Although previous authors have given several options like mental representations, verbal details and brand image as alternatives to touch but the use of touch-enabling technology can revolutionise the way online products are perceived. The study adds value by relating NFT with online preferences, showrooming and webrooming.
Improving relationship performance on platforms: the role of platform technology usage in promoting justice
Authors: Yang Qian , Wang Qiang , Zhao Xiande 
Published: June 2019

Purpose
Technology has dramatically changed the nature of interorganizational relationships and the ways partners interact with each other. In the new platform business model, platform technology usage seems to work as a governance mechanism to regulate operations and manage platform builder–platform participant relationships. To respond to these changes, this study aims to examine how platform technology usage in platform operations influenced the relationship quality between the platform builder and platform participants by promoting perceptions of three types of justice (procedural, distributive and informational).

Design/methodology/approach
The authors propose that it is through the perception of three types of justice (procedural, distributive and informational) that platform technology usage exerts its governance effect on the platform relationship. In doing this, the authors seek to answer the following two related research questions in the platform setting: How does platform technology usage drive relationship performance via different types of justice perceptions? Which type of justice affects relationship performance most effectively?

Findings
The results from a survey of 384 participant firms from two of the largest digital platforms for mobile/PC application in China reveal that platform technology usage leads to better relationship performance through enhanced perceptions of procedural, distributive, and informational justice. The positive impacts of procedural justice and distributive justice on relationship performance are greater than that of informational justice, while the impacts of procedural justice and distributive justice show no significant differences.

Originality/value
These findings provide novel insights into the role and mechanisms of platform technology usage in platform relationship management.