bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic Inflation and Stellar Mass. III. Revised Parameters for the Component Stars of NSVS 07394765
Authors: Healy Brian F. , Han Eunkyu , Muirhead Philip S. , Skiff Brian , Polakis Tom , Rilinger Anneliese , Swift Jonathan J. 
Published: July 2019

Abstract
We perform a new analysis of the M-dwarf–M-dwarf eclipsing binary system NSVS 07394765 in order to investigate the reported hyper-inflated radius of one of the component stars. Our analysis is based on archival photometry from the Wide Angle Search for Planets, new photometry from the 32 cm Command Module Observatory telescope in Arizona and the 70 cm telescope at Thacher Observatory in California, and new high-resolution infrared spectra obtained with the Immersion Grating Infrared Spectrograph on the Discovery Channel Telescope. The masses and radii we measure for each component star disagree with previously reported measurements. We show that both stars are early M-type main-sequence stars without evidence for youth or hyper-inflation (

,

,

,

), and we update the orbital period and eclipse ephemerides for the system. We suggest that the likely cause of the initial hyper-inflated result is the use of moderate-resolution spectroscopy for precise radial velocity measurements.
Marat et Castel : l’expérience du prisme revisitée
Authors: Blay Michel 
Published: July 2019

Dans cet article, sont présentés les enjeux post-newtoniens de l’étude des phénomènes de la couleur à partir de l’analyse des travaux critiques de Jean-Paul Marat et du Père Castel. Ces deux auteurs, en repartant de l’expérience newtonienne du prisme et en la réinterprétant à leur manière ne formulent en aucune façon des critiques au sens physique de l’expérience du prisme mais soulignent, dans une perspective épistémologique, la spécificité de cette expérience et la nature originale de ce qu’est un fait en science physique. Ces deux analyses critiques constituent donc un apport tout à fait important tant sur le plan de l’étude des couleurs que sur celui de la réflexion épistémologique. Après avoir rappelé les principaux aspects de la théorie newtonienne des phénomènes de la couleur, j’analyse avec soin la reprise de l’expérience du prisme par Marat et Castel, tout en attirant l’attention, d’une part, sur les problèmes liés à la perception visuelle de Marat et, d’autre part, sur les conséquences de la théorie newtonienne du point de vue de l’analyse de la sensation colorée au 18 e siècle.
Palettes et tableaux : des laboratoires de la couleur ?
Authors: Guichard Charlotte 
Published: July 2019

Intense objet de réflexion pour les peintres, la couleur fut redéfinie aux confins de la physique de la lumière, de la chimie des pigments et de la théorie de l’art tout au long du 18 e siècle. Dans cet article, le tableau est envisagé à la manière d’une « trading zone » (P. Galison), un laboratoire où les différentes conceptions de couleurs furent mises à l’épreuve. En s’affranchissant notamment, avant le moment romantique, des théories du clair-obscur, certains peintres comme François Boucher utilisèrent une nouvelle palette et expérimentèrent un jeu nouveau sur la distribution des lumières et des ombres dans le tableau. À l’horizon de notre réflexion, émerge l’idée que les peintres des Lumières furent pleinement engagés dans les innovations optiques, chimiques et esthétiques qui transformèrent les usages de la couleur dans les arts visuels autour de 1800.
Le style « couleur de rose » de Marguerite de Lubert
Authors: Gladu Kim 
Published: July 2019

Cet article se penche sur l’usage de la « couleur de rose » en littérature, à partir d’un texte exemplaire à cet égard : La Princesse Couleur-de-ros e et le Prince Céladon (1743) de Marguerite de Lubert. On verra que la couleur de rose y sert de métaphore du style rococo qui cherche à créer un effet sensible sur le lecteur, particulièrement à travers l’analyse de l’épisode où la princesse se trouve métamorphosée en livre et offerte à la lecture, au regard et aux caresses avides du prince Céladon. Le texte met alors à profit une écriture du plaisir pur, tel que défini dans le célèbre discours préliminaire servant de préface à Tecserion (1743), et qui n’est pas étrangère aux réflexions sur le coloris dans le domaine des beaux-arts.
Des pouvoirs de la couleur dans La Nouvelle Héloïse
Authors: Martin Christophe 
Published: July 2019

À première vue, La Nouvelle Héloïse semble illustrer exemplairement une pauvreté chromatique assez générale dans le roman des Lumières qui, le plus souvent, ne semble nullement refléter l’importance nouvelle alors accordée aux couleurs. Lire La Nouvelle Héloïse au prisme de la couleur peut sembler d’autant plus paradoxal que le roman a toute chance d’avoir été composé à peu près au moment où Rousseau développe tout un discours anticoloriste dans l’ Essai sur l’origine des langues . Faut-il dès lors ne percevoir dans la Julie qu’une « condamnation puritaine de la couleur », selon la formule de Bernadette Fort ? En réalité, non seulement Rousseau ne reproche pas à la couleur de farder la réalité, mais il ne l’accuse pas non plus de séduire artificiellement les sens. À tenir compte des sujets d’estampe et à relire attentivement nombre de lettres du recueil, c’est au contraire toute une esthétique de la suggestion chromatique qui se laisse discerner dans le roman.
Adrien Lamourette et les philosophes : rupture ou continuité ?
Authors: Brucker Nicolas 
Published: July 2019

Adrien Lamourette a-t-il varié dans son jugement sur les philosophes, leur rôle dans la Révolution et la crise religieuse ? Une approche historique, privilégiant une périodisation stricte et des facteurs circonstanciels, pencherait vers le oui, à la manière de la satire qui en 1792 oppose trois Lamourette. Les textes publiés avant et après les événements font apparaître d’évidents indices de continuité : Lamourette ne cesse de réfléchir sur un possible rapprochement entre les deux bords du monde intellectuel, sur une possible conciliation entre clercs et philosophes, et plus largement sur le lien entre religion et philosophie, faisant de la Révolution le pivot d’une pensée intégratrice, pensée qu’il n’a fait cependant qu’esquisser.
Evaluation of an Electronically Delivered Learning Module Intended for Continuing Education of Practicing Registered Nurses: A Pretest–Posttest Longitudinal Study
Authors: Schilinski Susan , Hellier Susan D. , Cline Thomas W. 
Published: July 2019

Background:
A widely used method for distributing continuing education to health care professionals is via electronically delivered learning modules (EDLM). The purpose of this study is to determine if RNs retain and value education provided by an EDLM.

Method:
This is a one-group pretest–posttest and longitudinal study employing survey methodology. RNs completed an electronically delivered sepsis educational module, an immediate posttest, and then a posttest 4 weeks later. Additionally, the researchers measured participants' feelings and practices regarding EDLMs.

Results:
The mean value for total knowledge scores increased immediately postintervention then decreased to near baseline after 1 month. Additionally, participants reported that EDLMs did not increase their knowledge, nor did they value EDLMs.

Conclusion:

Our findings suggest that didactic information received via EDLMs may have minimal sustained impact on nurses' knowledge. Participants' lack of knowledge retention may be affected by module and evaluation design.

[
J Contin Educ Nurs.
2019;50(7):331–336.]
A Common Extension of Arhangel’skĭ’s Theorem and the Hajnal–Juhász Inequality
Authors: Bella Angelo , Spadaro Santi 
Published: July 2019

AbstractWe present a result about $G_{\unicode[STIX]{x1D6FF}}$ covers of a Hausdorff space that implies various known cardinal inequalities, including the following two fundamental results in the theory of cardinal invariants in topology: $|X|\leqslant 2^{L(X)\unicode[STIX]{x1D712}(X)}$ (Arhangel’skiĭ) and $|X|\leqslant 2^{c(X)\unicode[STIX]{x1D712}(X)}$ (Hajnal–Juhász). This solves a question that goes back to Bell, Ginsburg and Woods’s 1978 paper (M. Bell, J.N. Ginsburg and R.G. Woods, Cardinal inequalities for topological spaces involving the weak Lindelöf number, Pacific J. Math. 79(1978), 37–45) and is mentioned in Hodel’s survey on Arhangel’skiĭ’s Theorem (R. Hodel, Arhangel’skii’s solution to Alexandroff’s problem: A survey, Topology Appl. 153(2006), 2199–2217).In contrast to previous attempts, we do not need any separation axiom beyond $T_{2}$.
Effect of Surface Oxidation on Performance of Ti3C2Tx/MO Composite as Anode Materials for Lithium Ion Batteries
Authors: Ali Adnan 
Published: July 2019

Recently, a new group of 2D material showed a great promise in supercapacitors and batteries application due to their good conductivity as well as hydrophilic nature [1]. It has general formula Mn+1Xn, where n = 1, 2 or 3, M is an early transitional metal and X is C and/or N [2]. According to X-ray photoelectron spectroscopy (XPS) and energy dispersive x-ray spectrometry (EDS) studies, MXenes can be terminated with a mixture of O, OH, and/or F groups depending on the chemical etching method and post-treatment. The as-synthesized MXenes are electronically conducting and hydrophilic, which is a unique combination. Ultrasonication can be used to delaminate the 2D layers and produce single-layer and few-layered flake [3].As MXenes are hydrophilic, once delaminated, they form stable, surfactant-free colloidal solutions in water. The possibility of intercalating MXenes with various organic molecules plays a critical role for utilizing MXene in a range of applications, from polymer reinforcements to energy storage systems. The MXenes’ 2D morphology, together with to their good electronic conductivities, render them strong candidates for many applications that range from sensors and electronic device materials to catalysts in the chemical industry, conductive reinforcement additives to polymers, and electrochemical energy storage materials, among many others [4].We have used hydrothermal route to synthesize nanocomposite material i.e. Ti3C2Tx/MO (MO = Fe2O3, Co3O4). After hydrothermal treatment, nanocomposite was calcinated at 400°C for 4 hours to get rid of entrapped moisture. Nano-composite was characterized using scanning electron microscopy, transmission electron microscopy and X-ray diffraction. After synthesis, nanocomposite was applied as anode in lithium ion battery. Anode was fabricated as thin film using doctor blade on copper foil.Ti3C2Tx/Fe2O3 composite as anode material exhibited discharge and charge capacities of 190 and 120 mAh/g, respectively. Characterization shows that the MO nanoparticles are not uniformly distributed and also X-ray diffraction analysis has confirmed that Ti3C2Tx has oxidized during hydrothermal treatment. Due to oxidation, the surface of Ti3C2Tx was decomposed to TiO2 and leaving carbon sheets behind which played a big role in decreasing conductivity of the anode. In turn, it has greatly affected its performance as anode material in the lithium ion batteries. To enhance its performance as anode material in Lithium ion batteries, it is extremely important to protect it from oxidizing. For this purpose, it should be exfoliated in a medium other than water. Besides this, metal oxide should be uniformly distributed.
Isolation and Identification of Potentially Pathogenic Vibrio Species from Qatari Coastal Seawaters
Authors: Anand Anjana , Zeyara Aisha , Al Malaki Amina , Al-Ghanim May M. , Hitha P.K. , Al deen Saad Taj , Al Marri Masoud , Fotedar Rashmi 
Published: July 2019

The genus Vibrio accounts for a major group of marine and estuarine bacteria capable of causing diseases in various aquatic organisms including fishes, corals, shellfish's and shrimps. Infections with these organisms have profound environmental and economic consequences. In the present study, 52 isolates of Vibrio species were isolated from the water samples collected from 14 sites surrounding Qatar during the winter season. Using 16S rRNA gene sequence analysis and MALDI-TOF MS we identified 13 different luminous and non-luminous Vibrio species. V. alginolyticus (50%) was the predominant species followed by V. harveyi (11%), V. owensii (7%), V. nigripulchritudo (6%), V. rotiferianus (6%), V. mediterranei (6%), V. hepatarius (2%), V. shilonii (2%), V. maritimus (2%), V. coralliilyticus (2%), V. tubiashii (2%), V. parahaemolyticus (2%), and V. proteolyticus (2%). We were able to identify all (100%) isolates using 16S rRNA, (>94 percentage similarity) as compared to MALDI TOF-MS which could correctly identify only 60% isolates. Majority (70%) of the potentially pathogenic Vibrio's isolates of Vibrio's were recovered from the fishing ports of Qatar namely Al-Khor and Al-Wakra. The isolation of various pathogenic species of Vibrio's from the Qatari marine environment indicates the potential sanitary risk and stresses the need for further studies to prevent infections.Acknowledgments:This research was supported by the research grant (Grant NPRP 6-647-1-127) from the Qatar National Research Fund (a member of Qatar Foundation) to R. Fotedar (Ministry of Environment, Qatar), Thorsten Stoeck (L, Germany), Teun Boekhout (CBS- KNAW, The Netherlands) and Jack Fell (RSMAS,USA).
The Role of 4-hydroxynonenal in Human Preadipocyte Proliferation and Differentiation
Authors: Elrayess Mohamed A. , Al Muraikhi Shamma , Al-Khelaifi Fatima , Al-Yafei Afnan , Bashah Moataz , Jaganjac Morana 
Published: July 2019

Accumulation of lipid peroxidation products in response to oxidative stress can cause dysfunction and pathology in a variety of tissues. In this study, we investigated the presence of 4-hydroxynonenal (4-HNE), the most abundant lipid peroxidation end product, in paired subcutaneous (SC) and omental (OM) tissues obtained from morbidly obese individuals undergoing weight reduction surgery. We further assessed 4-HNE effect on proliferation and differentiation of preadipocytes derived from these tissues in two metabolically distinct groups. Levels of 4-HNE accumulation were positively correlated between the paired SC and OM tissues (R2 = 0.9, p = 0.01) and exhibited a higher accumulation in OM-adipocytes and connective tissues compared to SC-derived counterparts. Exposure of tissues-derived preadipocytes to physiological levels of 4-HNE caused inhibition of proliferation and differentiation of SC, but not OM-derived preadipocytes. When samples were dichotomized into insulin sensitive (IS) and insulin resistant (IR) groups based on their HOMA-IR index, 4-HNE treatment caused a greater reduction of both proliferation by 76% with a mean difference of 11.4% (3–45.3) and differentiation capacity by 56% with a mean difference of 25.9% (3.9–55.7) in IS compared to IR. This data suggest that 4-HNE induced oxidative stress plays a role in the regulation of adipocyte proliferation and differentiation in a depot and insulin sensitivity-specific manners and may therefore contribute to metabolic dysfunction associated with insulin resistance. This research was sponsored by Qatar National Research Fund (QNRF), Grant number NPRP6-235-1-048.
Filamin A is Reduced and Contributes to CASR Sensitivity in Human Parathyroid Tumors
Authors: Terranegra Annalisa , Mingione Alessandra , Verdelli Chiara , Brasacchio Caterina , Pivari Francesca , Dogliotti Elena , Corbetta Sabrina , Soldati Laura 
Published: July 2019

BackgroundParathyroid tumors display reduced sensitivity to extracellular calcium ([Ca2+]o). The parathyroid cell sensitivity to [Ca2+]o is mediated by the calcium-sensing receptor (CASR), a G-protein-coupled receptor interacting with the scaffold protein filamin A (FLNA). We investigated: the FLNA expression in human parathyroid tumors, its effect on the CASR membrane stabilization, and on ERK signaling activation in HEK293 cells, the effect of the C-terminal CASR variants (R990G) on the interaction with FLNA.MethodsFLNA expression was analyzed by immunohistochemistry and immunofluorescence in parathyroid tumors and in cells from parathyroid adenomas (PAds). Endogenous FLNA in HEK293 cells transfected with the CASR variants was silenced by siRNA technique. Results FLNA expression was down-regulated in human parathyroid tumors; In 74 PAds, FLNA mRNA levels positively correlated with CASR levels. In HEK293 cells transfected with 990R-CASR or 990G-CASR, FLNA silencing reduced both the total and membrane protein expression levels. However, in presence of endogenous FLNA, 990G-CASR expression in cell membrane was higher than that of the 990R-CASR. FLNA loss reduced significantly p-ERK levels induced both 990R-CaSR and 990G-CaSR. Treatment with the CASR agonist R568 delete the effect of FLNA loss and restoring 990G-CASR sensitivity to [Ca2+]o in absence of FLNA.ConclusionsFLNA is down-regulated in parathyroid tumors and paralleled the CASR expression levels. Loss of FLNA reduced the CASR expression levels and the CASR-induced ERK phosphorylation. The CASR 990G allele was associated with increased sensitivity to [Ca2+]o, though FLNA was required to determine the 990G-CASR higher expression and activity than that of 990R-CASR protein.
Application of Pulsed Streaming Potentials in Plastic Microfluidic Channels for Quantitative Point-of-Care Determination of Cardiac Markers
Authors: Elazazy Marwa , Alvarez Julio 
Published: July 2019

Acute myocardial infarction (AMI) is a well-recognized angiocardiopathy that can be spotted by a rise and fall of “chemical biomarkers” in a clinical context. Biomarkers are then, valuable indicators, together with ischemic symptoms, of an impaired cardiac function. Assay of Cardiac troponin T (cTnT), the biomarker of choice, is now an indispensable element in the medical practice followed to diagnose and control AMI. Though being proved sensitive and cardiospecific, the enhancement of diagnostic sensitivity attained using CTnT, have noticeably come with a reduction in specificity. Herein, we report a new sensing strategy based on pulsed streaming potential for direct determination of CTnT. The current biosensor consists of a patterned microchannel built with commodity thermoplastic cyclo olefin copolymer (COC). Specific binding of “avidin to biotin” on an “EDC-NHS” modified microchannel was used to tether biotinylated “anti-troponin T monoclonal Ab” to our target “CTnT”. Furthermore, the selectivity of the created platform was tested with success in serum samples. The analytical response to this system was measured by changes in magnitude of the streaming potential and correlated with the amount of analyte bound to the sensor surface. Different from the well-established biochemical assays adopted for cTnT, the current biosensor does not require labeling (fluorescent, electrochemical or radioactive) or usage of tedious chemical procedures. In addition, a stable quick response is attained under pulsed flow not steady state conditions, which permits a real time analysis. The linear region (1.9–6.5 μg/mL) matches with the clinically relevant concentrations of cTnT in human serum which has a cutoff value of 4 ng/mL.
Histone Deacetylase Inhibitor Trichostatin A (TSA) and DNA Methyltransferase Inhibitor 5-aza-2′-deoxycitidine (5-AZA) Enhanced the Cisplatin (CDDP) Induced Cytotoxicity of Neuroblastoma Cells, in Vitro
Authors: Busselberg Dietrich , Varghese Elizabeth , Florea Ana-Maria 
Published: July 2019

Neuroblastoma is a childhood cancer that is frequently treated with CDDP. Upon chemotherapeutic treatment, neuroblastoma patients might develop drug resistance. A large body of evidence associates the cytotoxic effect of CDDP in cancer cells with the formation of DNA adducts and thus interference with the DNA replication of cancer cells but also with the increase of the intracellular calcium concentration ([Ca2+]i) that leads to apoptosis. Nevertheless, it is not understood how epigenetic mechanisms, such as DNA methylation and chromatin modification might influence the effect of CDDP on cytotoxicity and [Ca2+]i of neuroblastoma cells.Therefore, here we investigate in human neuroblastoma cell lines SH-SY5Y and IMR-32 the changes in cytotoxicity and calcium homeostasis induced by the treatment with epigenetic modulators: TSA and 5-AZA but also in combination with CDDP.Treatment schemes for calcium homeostasis experiments were performed in four different groups: A) treatment with CDDP only (control); B) acute treatment with 5-AZA or TSA (without CDDP); C) pre-treatment with both 5-AZA and TSA (before CDDP application), D) pre-treatment with 5-AZA (before CDDP). For cytotoxicity test: the Trypan Blue Cytotoxicity test was performed using the automated cell counter ViCellXR (Beckman Coulter, Germany), for exposure times ranging 24–72 h. The concentrations used were for 5-AZA ranging 1–200 μM while for TSA 1–10 μM were used.The results showed significant increase of neurblastoma cells cytotoxicity upon treatment, especially for the combinatory treatment 5-AZA and TSA. We observed a time and concentration dependent increased cytotoxicity. The most efficient treatment was the combination 5-AZA and TSA, showing additive effects. TSA showed higher efficiencity triggering cytotoxic effects in neuroblastoma cells than 5AZA. Furthermore, the combinatory treatment of neuroblastoma cells with epigenetic modulators and CDDP increased the efficiency of CDDP treatment in a synergistic manner, effect that could be confirmed in IMR32 cells. Thus, the combination 5-AZA/CDDP or TSA/CDDP or 5-AZA /TSA/CDDP was more effective in triggering cell death of neuroblastoma cells than each of the compound alone.For the investigation of changes in [Ca2+]i we performed calcium imaging studies using the calcium sensitive dye Fluo-4-AM in Tyrode's buffer with calcium (1.5 mM). Fluorescent images were taken with Olympus Microscope BX51 Wi with Xenon Arc Burner and “Xcellence rt” software. CDDP (1 μM) treatment (control group) increased the [Ca2+]i (30.3% ± 11.7) group “A” in SH-SY5Y cells. This effect of CDDP was reversed by the pretreatment with 5-AZA and TSA group “C” (5.1% ± 5.1) (p
Protein Engineering of Glucarpidase to Improve Cancer Therapy Strategies
Authors: Goda Sayed K , Alqahtani Alanod , Groves Mathew , Domling Alex 
Published: July 2019

Antibody Directed Enzyme Prodrug Therapy (ADEPT) is a technique used in cancer treatment, which convert a prodrug to a powerful cytotoxic drug only in the vicinity of the tumor. The technique relies on a bacterial enzyme, glucarpidase (former name: carboxypeptidase G2, CPG2). Also the glucarpidase is a very effective enzyme for detoxification of methotrexate, (MTX) which serves as an important component of various chemotherapeutic regimens for the treatment of cancer patients.Repeated cycles of ADEPT and the use of wild type glucarpidase in detoxification are essential but are hampered by the human antibody response to the enzyme. Additionally, glucarpidase has a relatively slow action in detoxification.The aim of the work is to provide solutions to overcome the pitfalls of the techniques through the application of different strategies.In our work we successfully isolated new glucarpidase produces from soils. We cloned and overexpressed the novel gene in E.coli. The new recombinant glucarpidase has been characterized. We also produce different variants of our new gene using different strategies. These variants will be investigated to isolate glucarpidase with higher activity and glucarpidase which avoid the immune system.