bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transurethral Resection of Bladder Tumor – Elements of the Surgical Technique
Authors: Rohith Gorrepati , Pal Bipin Chandra , Panda Arabind 
Published: November 2024

Summary
Transurethral resection of bladder tumor (TURBT) is one of the common uro-oncological interventions for diagnosing, staging, and treating bladder cancer, particularly in non–muscle-invasive and select muscle-invasive cases. As a minimally invasive, repeatable procedure performed through natural orifices, TURBT aims to achieve complete tumor excision and provide sufficient tissue for histopathological evaluation, including tumor type, grade, and stage. However, considerable variability in the technical proficiency of urologists affects the quality of resection and clinical outcomes. Evidence suggests optimal results are typically attained after 100 to 170 TURBT procedures, particularly in complex cases. To enhance surgical quality and reduce the likelihood of early recurrence, particularly in non–muscle-invasive bladder cancer, the adoption of standardized protocols and surgical checklists is recommended. Despite its deceptively simple appearance, TURBT remains the cornerstone of bladder cancer management, with continuous refinement in surgical technique and adherence to best practices critical for achieving favorable oncological outcomes.
Challenges with the Management of Young Women’s Breast Cancer in Gulf Countries and the Middle East
Authors: Al Ajmi Adil Aljarrah , Ayaad Omar , Al Aghbari Suad , Al Balushi Mahim Nasser , Koziha Eman K. , Al-Ishaq Zaid , Al-Baimani Khalid , Al-Qassabi Badriya S. , Pignol Jean-Philippe 
Published: November 2024

Abstract
Breast cancer (BC) remains a significant concern among young women aged <40 years, particularly in the Middle East, where the incidence rates are rising. Many advancements in treating BC at this young age are studied in Western countries. Therefore, understanding the unique challenges faced by this demographic group is vital for tailored interventions, as they often experience distinct risk factors, disease characteristics, and outcomes compared to older women. A systematic literature search was conducted to find relevant recent studies published between 2019 and 2024. Databases including PubMed, Scopus, and Web of Science were searched using the following keywords: “breast cancer” AND “Middle East” AND (“awareness” OR “knowledge” OR “screening” OR “quality of life” OR “incidence” OR “histology” OR “stage” OR “grade” OR “survival rates” OR “risk factors” OR “genetic predispositions” OR “epidemiology”). The four available cancer registries in the Middle East were also reviewed, and incidence rates from the global burden of disease were extracted. This study explores various aspects of BC among young women in the Middle East, including epidemiology, stage and grade distribution, histological subtypes, molecular and genetic profiles, and prognosis and survival outcomes. Clear inclusion and exclusion criteria were followed, and two breast specialists reviewed the titles and abstracts. One hundred and thirty-seven articles were excluded from the 177 titles after title and abstract review. The findings highlight significant variations in awareness, screening practices, and treatment modalities across the region. We concluded that the Middle East region faces significant challenges with BC in young women. The higher burden compared to Western countries is due to its high frequency in the BC population and the more advanced stage at presentation. This could be linked to lower awareness, challenging healthcare access, cultural stigmas, and potential differences in genetic and lifestyle factors. There is a need for improved public health initiatives.
Exploring Differences in Breast Cancer Presentation, Recurrence and Survival by Race/Ethnicity among Young Women in the Prospective PYNK Database
Authors: Chehade Rania , Juni Yonina , Zhu Jie Wei , Tavanger Farideh , Jerzak Katarzyna J. , Warner Ellen 
Published: November 2024

Abstract

Background:
While socioeconomic factors contribute to most of the disparities in breast cancer (BC) outcomes between countries, the contribution of biological factors related to race/ethnicity has not been fully explored. Using our prospective database of young BC patients referred from the Greater Toronto Area, we compared clinical/pathological features of the BC, distant recurrence-free survival, and BC-specific survival according to patient race/ethnicity.

Methods:
A chart review was conducted of the 240 women aged 40 years and younger with a new diagnosis of BC who were seen at the Sunnybrook Odette Cancer Center (an academic tertiary referral cancer center in multiethnic Toronto, Canada) between February 2008 and January 2015 and enrolled in the prospective PYNK database. Associations between patients’ race/ethnicity (classified into five groups) and personal characteristics (age, weight, education, and estimated household income), results of germ-line genetic testing, tumor characteristics, treatment, and clinical outcomes were assessed.

Results:
Among the 209 women (87%) for whom parental race/ethnicity was known and who were not of “mixed” ancestry, race/ethnicity was as follows: Caucasian 57.4% (n = 120), Black 8.6% (n = 18), East Asian 15.8% (n = 33), South Asian 8.6% (n = 18), and South-East Asian 9.6% (n = 20). Median age at the diagnosis of BC was 37. Median tumor size was 2.5 cm, and 58% had lymph node involvement. The majority of patients had hormone receptor-positive/human epidermal growth factor receptor 2 (HER2)-negative BC, 26% had HER2-positive disease, and 13% had triple-negative BC (TNBC). One hundred and seventy-five (83.7%) patients were treated with chemotherapy, 51 (29.1%) of whom received it in the neoadjuvant setting. There were no statistically significant differences in median age, residence type (urban vs. rural), income level, germ-line genetic test results, tumor histology (lobular vs. ductal), BC subtype, stage of disease at presentation, or proportion of patients who received chemotherapy across the various racial/ethnic groups. With a median follow-up of 10.5 years, South Asian women had a nonsignificantly higher risk of distant recurrence and BC-specific death compared with Caucasian women (hazard ratio [HR] = 1.27, 95% confidence interval [CI]: 0.49–3.29, P = 0.627 and HR = 1.42, 95% CI: 0.48–4.16, P = 0.521, respectively), while East Asian ethnicity was associated with lowest risk of distant recurrence (HR = 0.52, 95% CI: 0.18–1.49, P = 0.224) and BC-related death (HR = 0.36, 95% CI: 0.08–1.53, P = 0.167).

Conclusion:
Our study shows interesting trends of worse BC outcomes among South Asian women and better outcomes among those of East Asian descent. Future validation of our findings in a larger cohort of young women with BC would be of interest.
Развитие Нравственного богословия в XIX веке в Санкт-Петербургской духовной академии
Authors: А.И. Ранне 
Published: November 2024

Статья посвящена проблеме поиска путей развития Нравственного богословия моралистами Санкт-Петербургской духовной академии в XIX веке. Особое внимание уделено вопросу о соотношении нравственности и аскетической практики. Если с христианской точки зрения нравственная деятельность немыслима без аскетической практики, то следует ли аскетику рассматривать, как самостоятельный путь стяжания Благодати Божией? Аскетика — это основание нравственной деятельности, обусловленной Высшим Благом, как об этом говорится в притче о Страшном суде, либо же это аскетический путь отшельников пустыни, практика которых должна быть распространена на всех? М. М. Тареев обратил внимание на противоречие, которое присутствует в изложении этой проблемы у протопресвитера Иоанна Янышева в первом и втором изданиях его Православно-нравственного богословия. Рассматривая аскетизм как необходимое условие нравственного отношения к Богу, человеку и природе, протопресвитер Иоанн Янышев во втором, дополненном издании обратился к святоотеческому опыту великих христианских аскетов в изложении святителя Феофана Затворника.
The article is devoted to the problem of finding ways to develop moral theology by the 19th century moralists of the St. Petersburg Theological Academy. Particular attention is paid to the issue of the relationship between morality and ascetic practice. If, from a Christian point of view, moral activity is unthinkable without ascetic practice, then should asceticism be considered as an independent way of acquiring the grace of God? Is asceticism the basis of moral activity conditioned by the Supreme Good, as stated in the parable of the Last Judgment, or is it the ascetic path of the hermits of the desert, whose practice should be extended to everyone? M. M. Tareev drew attention to the contradiction that was present in the interpretation of this problem by Protopresbyter John Yanyshev in the first and second editions of his Orthodox Moral Theology. Considering asceticism as a necessary condition for a moral attitude towards God, man and nature, Protopresbyter John Yanyshev in the second, expanded edition turned to the patristic experience of the great Christian ascetics as presented by St. Theophan the Recluse.
Factor Analysis of the Instrument of Internal Quality Assurance to Non-Formal Education Institutions for Achieving Sustainable Development Goals (SDG)
Authors: Tohani Entoh , Fathurohman Muhamad , Setiana Dafid Slamet , Hardianto Deni 
Published: November 2024

Objective: The research aims to discover and analyze the factors which affect internal quality assurance in non-formal education institution as the basis for the preparation of standardized internal quality assurance instrument in non-formal education institutions.

Method: This research uses quantitative research method with confirmatory factor analysis as data analyzing technique. The research utilizes research population in community learning center (CLC) around Yogyakarta province and Kalimantan Utara province. The samples are selected randomly from 117 institutions.

Results and Discussion: The result shows that the institution’s internal quality is influenced by 21 factors. These 21 factors explain 123 variable items with 82,264% rate. In conclusion, the 123 variable items can form beneficial internal quality assurance instrument for non-formal education institutions internally and externally by taking into account of the conditions for successful implementation of internal quality assurance using the instrument.

Originality/Value: Non-formal education (NFE) institutions are required to continuously improve the quality education like performance in learning aspect and education management. By paying attention to the quality aspects of education, non-formal educational institutions are able to contribute to sustainable development goals. Therefore non-formal institutions should conduct internal quality management effectively with valid instruments. However, instruments that are valid and relevant to non-formal education are not yet available. So this study becomes the basis for developing internal quality assurance instruments for non-formal institutions that are valid and relevant to the needs of non-formal education institutions. Internal quality assurance instrument may become the key to non-formal education institutions to result in objective and beneficial decision for the institutions to survive.
Sistem Informasi Akademik Berbasis Web di SMA Negeri 1 Waikabubak Kabupaten Sumba Barat
Authors: Lema Stefen Wiljon Tonu , Janga Adelbertus Umbu , Engge Emerensiana D 
Published: November 2024

Perkembangan teknologi informasi telah banyak memberikan kontribusi yang nyata bagi kemajuan di bidang usaha atau instansi. Informasi merupakan sesuatu yang sangat dibutuhkan oleh manusia, karena dengan informasi seseorang akan mengetahui apa saja yang sedang terjadi disekitarnya. Juga dengan informasi seseorang akan mampu mengambil langkah-langkah apa saja dalam hal pengambilan keputusan. Penelitian di SMA Negeri 1 Waikabubak oleh peneliti memiliki tujuan untuk merancang sistem baru yang diharapkan dapat menyelesaikan permasalahan akademik di SMA Negeri 1 Waikabubak . Pada penelitian ini menggunakan metode pengembangan prototype dan metode pendekatan berorientasi objek dengan alat bantu perancangan yang diataranya diagram use case, Skenario, diagram Activity, diagram Sequence, diagram Class, diagram Deployment, diagram Component. Desain penelitian menggunakan metode deskriptif dan action research. Sistem ini dibuat dengan menggunakan Bahasa Pemrograman PHP yang menggunakan perangkat lunak Adobe Dreamweaver dan server database Mysql dengan menggunakan perangkat lunak Xampp. Dalam hal ini peneliti akan membangun sistem informasi akademik berbasis website, dimana proses absensi dapat dilakukan secara online dan datanya tersimpan ke database. Dengan dibangunnya sistem informasi akademik ini maka setiap masalah yang ada di SMA Negeri 1 Waikabubak diharapkan dapat terselesaikan dan proses akademiknya berjalan dengan cepat
Sistem Pendukung Keputusan Seleksi Penerimaan Bansos di Desa Kadi Pada Menggunakan Metode SAW
Authors: Ina Yulita Adi , Neno Friden Elefri , Rato Karolus Wulla 
Published: November 2024

Sistem Pendukung Keputusan atau Decision Support System (DSS) dapat menentukan hubungan antara kriteria, alternatif dan sebuah peristiwa Sistem pendukung keputusan adalah sistem yang memberikan informasi, pemodelan, manipulasi data yang bersifat interaktif bisa disimpulkan bahwa sistem pendukung keputusan merupakan metodologi untuk membantu pengambilan keputusan -yang bersifat interaktif. Proses pendataan yang dilakukan di Desa Kadi Pada Kecamatan Loura, Kota Tambolaka Kabupaten Sumba Barat Daya Provinsi Nusa Tenggara Timur masih menggunakan cara manual yaitu dengan mengisi formulir dalam bentuk kertas dan diseleksi satu persatu tanpa menggunakan alat bantu seperti sistem. Tentunya hal ini akan memperlambat kinerja panitia penyeleksi penerima bantuan sosial karena membutuhkan waktu yang lebih lama untuk menerima hasil seleksi, adanya hasil yang tidak akurat dan tidak tepat sasaran serta sulitnya melakukan pencarian data sehingga cara ini dianggap tidak optimal untuk digunakan. Ditinjau dari permasalahan yang ada, maka dibutuhkan suatu sistem yang berfungsi untuk memecahkan permasalahan tersebut agar proses seleksi penerima bantuan sosial tidak memakan waktu dan dinilai lebih optimal.Hasil perhitungan menggunakan metode SAW diperoleh rekomendasi nama-nama penerima program bantuan sosial berdasarkan perangkingan. Selain itu berdasarkan hasil pengujian sistem ini berjalan sesuai dengan fungsinya sehingga bantuan sosial dapat tersalurkan dengan tepat sasaran.
Pengaruh Penggunaan Instrumen Derivatif Terhadap Risiko Pasar: Analisa Sebelum dan Setelah Penerapan PSAK 71 Pada Institusi Keuangan Tahun 2015 – 2022
Authors: Razak Nishnurtia , Meiden Carmel 
Published: November 2024

Penelitian ini bertujuan untuk menguji pengaruh penggunaan instrumen derivatif (forward, futures, options dan swap) terhadap risiko pasar sebelum dan setelah penerapan PSAK 71 pada perusahaan sektor keuangan, serta mengetahui apakah penggunaan instrumen derivatif dapat lebih efektif. untuk mengurangi risiko pasar setelah penerapan PSAK 71. Penelitian menggunakan dasar teori portofolio modern, model penetapan harga aset modal dan teori penetapan harga arbitrase. Penggunaan instrumen derivatif dan penerapan PSAK 71 yang berorientasi pada manajemen risiko berdampak pada semakin besarnya volatilitas laba rugi. Penelitian dilakukan terhadap 50 perusahaan keuangan di BEI tahun 2015-2022, dengan pengambilan sampel purposive judgement dan pengujian hipotesis penelitian menggunakan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa penggunaan instrumen derivatif dimaksud terbukti mampu menjelaskan risiko pasar sebelum dan sesudah penerapan PSAK 71, namun tiap jenis pengaruhnya terhadap risiko pasar bervariasi, dimana penggunaan options terbukti berpengaruh positif sebelum penerapan PSAK 71, penggunaan futures secara konsisten berpengaruh negatif baik sebelum maupun sesudah penerapan PSAK 71, sedangkan forward dan swap tidak terbukti.
Numerical Simulation of Corrosive Flow in the Production End of Carbon Capture, Utilization, and Storage-Enhanced Oil Recovery Backflow Wastewater Pipeline
Authors: Hu Fangwen , Wang Lili , Fu Haipeng , Fu Shibo , Wang Huajie , Shi Jian , Li Dong 
Published: November 2024

In a carbon capture, utilization, and storage-enhanced oil recovery (CCUS-EOR) system process, the high carbon dioxide content and high acid value of the fluid at the extraction end are treated at the wastewater treatment station and then flow through the transfer station of the gathering system. The reinjection system’s pipelines at the transfer station are prone to corrosion and leakage risks. A steady-state nonisothermal flow and corrosion model was established to examine this corrosive phenomenon by utilizing the principles of fluid dynamics and electrochemical corrosion. The study examined how flow velocity, temperature, pressure, and pH affected the pipeline’s corrosion. Simulation results showed flow velocity increased in specific places of both straight and curved pipeline sections. The velocity near the inner wall of curved portions was higher, making them more susceptible to cavitation damage. Faster flow rates, lower pH values, higher temperatures, and smaller pipeline diameters all contributed to increased corrosion on the inner walls of wastewater pipelines. The highest simulated corrosion rate was 8.3162 mm/a corresponding to the smallest pipeline diameter (100 mm), lowest pH (4), highest temperature (60°C), and highest flow rate (36.847 m/s). When designing the CCUS-EOR system, the nonmetallic pipeline should be given priority. If carbon steel metal pipelines are utilized, it is best to use larger-diameter materials in the engineering design. Additionally, procedures such as adding corrosion inhibitors to regulate pH values and lowering the temperature of wastewater conveyance might be explored to reduce corrosion on the pipeline’s inner walls.
The role of the STING inflammatory pathway in hepatic damage in psoriasis with type 2 diabetes mellitus
Authors: Huang Shulin , Xie Kun , Li Xiaohong , Xu Xiangjin , Chen Pin 
Published: November 2024

IntroductionStudies have suggested a potential association between patients who have both psoriasis and diabetes and liver damage. However, the exact nature of this link has not yet been fully established. The objective of the current study was to examine the potential exacerbation of liver damage due to the coexistence of psoriasis and type 2 diabetes mellitus (T2DM) and to explore the impact of interferon gene stimulating factor (STING) on related damage.Material and methodsFour patient groups were recruited: normal individuals, individuals with diabetes, those with psoriasis, and those with both diabetes and psoriasis. Relevant indicators were collected to facilitate the investigation. Furthermore, a mouse model of psoriasis combined with T2DM was established. The expression levels of STING and inflammatory factors downstream of the pathway were detected in both the skin and liver tissues of the model mice.ResultsBased on our findings, patients with both psoriasis and T2DM exhibit abnormal liver function and increased STING expression in the skin (p < 0.05). In the in vivo experiments, liver tissues from model mice exhibited significantly elevated expression of STING and its downstream inflammatory factors, including NF-κB p65, interferon-β, interleukin (IL)-17A, and IL-23 (p < 0.05). The STING inhibitor-treated group displayed reduced skin damage and improved liver histopathology (p < 0.05).ConclusionsThe findings of the current study indicate that the STING inflammatory pathway is upregulated in the liver tissues of individuals with psoriasis and T2DM.
Coupling the regional climate model ICON-CLM v2.6.6 to the Earth system model GCOAST-AHOI v2.0 using OASIS3-MCT v4.0
Authors: Ho-Hagemann Ha Thi Minh , Maurer Vera , Poll Stefan , Fast Irina 
Published: November 2024

Abstract. Interactions and feedback between components of the Earth system can have a significant impact on local and regional climate and its changes due to global warming. These effects can be better represented by regional Earth system models (RESMs) than by traditional stand-alone atmosphere and ocean models. Here, we present the RESM Geesthacht Coupled cOAstal model SysTem (GCOAST)-AHOI v2.0, which includes a new atmospheric component, the regional climate model Icosahedral Nonhydrostatic (ICON)-CLM, which is coupled to the Nucleus for European Modelling of the Ocean (NEMO) and the hydrological discharge model HD via the OASIS3-MCT coupler. The GCOAST-AHOI model has been developed and applied for climate simulations over the EURO-CORDEX domain. Two 11-year simulations from 2008 to 2018 of the uncoupled ICON-CLM and GCOAST-AHOI give similar results for seasonal and annual means of near-surface air temperature, precipitation, mean sea level pressure, and wind speed at a height of 10 m. However, GCOAST-AHOI has a cold sea surface temperature (SST) bias of 1–2 K over the Baltic and North seas that is most pronounced in the winter and spring seasons. A possible reason for the cold SST bias could be the underestimation of the downward shortwave radiation at the surface of ICON-CLM with the current model settings. Despite the cold SST bias, GCOAST-AHOI was able to capture other key variables well, such as those mentioned above. Therefore, GCOAST-AHOI can be a useful tool for long-term climate simulations over the EURO-CORDEX domain. Compared to the stand-alone NEMO3.6 forced by ERA5 and ORAS5 boundary forcing, GCOAST-AHOI has positive biases in sea ice fraction and salinity but negative biases in runoff, which need to be investigated further in the future to improve the coupled simulations. The new OASIS3-MCT coupling interface OMCI implemented in ICON-CLM adds the possibility of coupling ICON-CLM to an external ocean model and an external hydrological discharge model using OASIS3-MCT instead of the YAC (Yet Another Coupler). Using OMCI, it is also possible to set up a RESM with ICON-CLM and other ocean and hydrology models possessing the OASIS3-MCT interface for other regions, such as the Mediterranean Sea.
Chemistry Learning Innovation: Implementation of Chemistry Learning Based on Cross-Cultural Religious Literacy as an Alternative to Building an Attitude of Religious Moderation
Authors: Hidayati Ririn Eva 
Published: November 2024

This investigation aims to decide the implementation of chemistry learning based on cross-cultural religious literacy (CCRL). This research is a quantitative and qualitative descriptive research. This research design was carried out using the One Shoot Case Study method. The data collection technique used was observation of the implementation of learning, and a questionnaire to measure students' understanding and behavior of religious moderation. Based on data analysis, the results obtained were: The teacher has implemented chemistry learning based on cross-cultural religious literacy with agood category, student activity in applying personal, comparison, and collaboration competence is 12.5; 19.75 and 20.25% and evaluation, negotiation and communication skills of 14.5; 16 and 17%. Students' understanding and behavior of religious moderation is included in the very good category.