bluuebunny/crossref_metadata_2025_split huggingface dataset:
An interpretative phenomenological study of midwives supporting home birth for women with complex needs
Authors: Madeley Anna-Marie , Williams Veronika , McNiven Abigail 
Published: October 2019

Background As the landscape of women presenting for maternity care changes, so do the challenges associated with providing quality, informed and compassionate care, particularly for women with complex needs. Aim To explore the lived experience of midwives in facilitating care for women with complex needs who choose to birth at home. Method A qualitative design is employed, using an interpretative phenomenological analysis informed by hermeneutic principles. Purposive sampling is used to recruit midwives through social media and JiscMail. Data are collected via semi-structured interviews. Findings Two interpretative themes arose. A ‘radical midwife’ embraces the phrase ‘radical’ by positioning midwives between traditional beliefs and practices, physiological processes, midwife knowledge and skill set by applying current evidence and professional context. A ‘conflicted midwife’ arises out of this dichotomy and exposes the realities of striving for radicality while the negotiating ‘the system’. Conclusions It is no longer acceptable to assume that home birth for women with complex needs is exceptional. This must be the catalyst to move towards a constructive discourse with midwives, women and the wider team to address and expand the evidence base and pathways to support those who are already facilitating this care and those who will inevitably continue to provide care ‘outside of current guidelines’.
What do relatives value most in end-of-life care for people with dementia?
Authors: Bolt Sascha , van der Steen Jenny , Schols Jos , Zwakhalen Sandra , Meijers Judith 
Published: October 2019

Background: End-of-life care for older people with dementia is often sub-optimal. Understanding the experiences of the relatives involved in the care of the person with dementia may help to improve care practice. Aims: To investigate relatives' experiences with end-of-life care for people with dementia, comparing the nursing home and home setting. Methods: In-depth interviews were conducted with 32 individuals who were bereaved of someone with dementia. Thematic analysis was performed to identify main themes from the data. Findings: Experiences translated into four themes: acknowledging human dignity; being recognised as an important caregiver; (not) talking about death and dying and making decisions together. A lack of person-centered care was mainly evident in nursing homes. Relatives took on a more prominent role in the care of the older person with dementia when the relative was cared for in a home setting and this involvement in the care of the older person was something that the relatives valued. Surrogate decision-making induced similar challenges in both settings. Conclusion: It is important that healthcare professionals inform and support relatives to help them make decision about end-of-life care and preferences. Nursing homes should learn to offer the same standard of person-centred care as a home care setting, and ensure that relatives are still involved in the care of the person with dementia.
Team approaches in palliative care: a review of the literature
Authors: Fernando GVMC , Hughes Sean 
Published: October 2019

Background: Interdisciplinary team involvement is commonplace in many palliative care settings across the world. Teamwork is perceived by many experts as an indispensable functionality of palliative care teams. Significantly different structural and functional attributes of these teams between regional and organisational contexts could potentially act both as strengths and weaknesses towards their overall productivity. The sustainability and resilience of the team also has an indirect bearing on the team functioning. Aim: This article describes international evidence on dynamic palliative care teams with a view of how and when they function efficiently or adversely. Emphasis is also placed on studies that suggest means to mitigate the conflicts and limitations of teamwork in palliative care and related healthcare settings. Findings: Evidence strongly suggests that palliative care is best delivered through a multidisciplinary team approach. Conclusion: The overall performance of a healthcare team is largely determined by the supportive work environment built through effective communication, leadership skills and mutual respect.
Comparison of intravitreal antifungal 100 μg voriconazole and 5 μg amphotericin B in experimental <em>Aspergillus flavus</em> endophthalmitis model in rabbits
Authors: Arianti Alia , Setiabudy Rianto , Rozaliyani Anna , Siregar Nurjati Chairani , Susiyanti Made 
Published: October 2019

BACKGROUND Fungal endophthalmitis is a sight-threatening disease associated with high morbidity and Aspergillus sp. is the most common causes. Voriconazole (VCZ) and Amphotericin B (AmB) are the most used antifungal drugs, while head-to-head comparison for in vivo intravitreal efficacy is still unknown. This study was aimed to compare the efficacy of both agents against Aspergillus flavus.
METHODS A randomized, masked, controlled-experimental study was conducted on 15 albino New Zealand white rabbits. Endophthalmitis was induced by intravitreal inoculation of Aspergillus flavus. Intravitreal injection was given 24 hours post-inoculation, the rabbits were divided into three groups; 100 μg/0.1 ml VCZ intravitreal injection, 5 μg/0.1 ml AmB, and control. Clinical evaluation of corneal opacity, aqueous cells and flare, and vitreous opacity using Yang’s method of quantification were performed at day 1, 3, 5, 7, and 10 after treatment. Mycology quantitative analysis and histopathological examination were performed at the final evaluation.
RESULTS Clinical evaluation showed improvement of inflammation in the VCZ and AmB treatment groups (Δ score −2.1 [2.8] and −1.0 [3.2]) compared with the control group (Δ score 0.8 [3.1]). Although the VCZ group demonstrated a better clinical response with less inflammation and relatively intact retina structures in the histopathology result. Number of fungal colony was significantly less in AmB group (CFU/0.1 ml, p < 0.05).
CONCLUSIONS Favorable clinical improvement was shown in VCZ group compared to AmB group. Intravitreal VCZ showed a better clinical response tendency for Aspergillus flavus-induced endophthalmitis in rabbits.
Intravitreal anti-vascular endothelial growth factor injection combined with panretinal photocoagulation for neovascular glaucoma in Indonesian patients with diabetes mellitus: a prospective study
Authors: Artini Widya , Gracia Ajeng , Kekalih Aria , Oktariana Virna Dwi , Victor Andi Arus , Bani Anna Puspitasari 
Published: October 2019

BACKGROUND The aim of this study was to determine the levels of vascular endothelial growth factor (VEGF) in the aqueous humor and the effect of intravitreal anti-VEGF injection combined with panretinal photocoagulation (PRP) on the management in diabetes mellitus (DM) patients with neovascular glaucoma (NVG).
METHODS This study was a prospective, interventional study in DM patients with NVG. Paracentesis followed by intravitreal bevacizumab (IVB) injection was performed in all eyes. The concentration of VEGF obtained from paracentesis was measured. In week-1, the intraocular pressure (IOP), sectorial iris neovascularization (NVI), and visual acuity were documented, and management was continued with PRP laser over a period of 1 week. All parameters and additional interventions performed after PRP were also recorded.
RESULTS A total of 18 eyes from 17 patients were studied. The mean (SD) level of VEGF in the aqueous humor was 3,864 (1,468) pg/ml, and the mean (SD) of initial IOP was 39 (10.2) mmHg. There was a significant reduction in IOP in week-1 after the first intervention to 24.4 (8.0) mmHg (p = 0.001); however, at 2 weeks the IOP increased to 30.4 (6.7) mmHg. NVI showed significant regression in week-1 after IVB combined with PRP laser (p < 0.05). All eyes required additional glaucoma implants (14 eyes) and cyclocryotheraphy (4 eyes).
CONCLUSIONS In the eyes of diabetes patients with NVG, VEGF levels were high. With the use of IVB, the IOP was reduced, and NVI regressed; however, due to the severe stages of disease, all eyes required glaucoma surgery.
Cranberries for women with recurrent urinary tract infection: a meta-analysis
Authors: Tambunan Made Parulian , Rahardjo Harrina Erlianti 
Published: October 2019

BACKGROUND Cranberries are the most widely used nonantibiotic prophylaxis for recurrent urinary tract infection (rUTI) in women; however, their efficacy still remains uncertain. Hence, this meta-analysis was aimed to assess the effectiveness, safety, and adherence of cranberry as a prophylactic drug for treating rUTI.
METHODS Literature search was conducted using PubMed, EBSCO, Science Direct, Scopus, Cochrane, and Google Scholar. Studies were screened for duplication, inclusion and exclusion criteria, and then reviewed by two authors independently. This included all randomized controlled trials of cranberry derivatives versus placebo and antibiotic prophylaxis. Cochrane risk-of-bias assessment tools were used to evaluate the quality of the study. Quantitative analysis was performed using the Review Manager 5.0 software.
RESULTS Nine studies were included. Among 1,542 participants, cranberry consumption reduced incidence of rUTI in women compared with placebo (p = 0.02). The subgroup analysis revealed that only cranberry capsules were superior to placebo (relative risk [RR] = 0.67, 95% confidence interval [CI] = 0.45–0.98), but not for cranberry juice (RR = 0.85, 95% CI: 0.7–1.04). Antibiotics had better outcome than cranberry for rUTI (RR = 0.83, 95% CI = 0.70–0.98). Most of the participants experienced minor adverse events such as rash and gastrointestinal symptoms. There was also a good adherence rate, ranging from 90.3–99% monthly dose.
CONCLUSIONS Cranberry, especially cranberry capsule consumption, had a significant effect in reducing the incidence of rUTI compared with placebo, with good adherence rates, and minor adverse events. In contrast, although antibiotic use had a greater efficacy, it was associated with a higher risk of severe adverse events.
Neurophysiological effects of corticotropin-releasing factor in the undergoing sections of the olfactory area of the rat cerebral cortex
Authors: Mokrushin A. A. , Shalyapina V. G. 
Published: October 2019

Application of corticotrophin-releasing factor (CPF) in concen­trations of 10-9-10-8 M on the rat olfactory cortex slices induced activation of the pre- and postsynaptic excitatory components of the focal potentials recorded in the slices. The amplitude and du­ration of α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic and N-methyl-D-aspartate components of postsynaptic evoking potentials increased upon exposure to CRF, while the amplitude of GABAB-mediated inhibitory postsynaptic potentials was sup­pressed. At higher concentrations of CRF (10-8 M) epileptiform charges were recorded in the cells. CRF effects were reversible and eliminated after washing. A long (90 min) exposure induced the phenomena similar to long-term posttetanic potentiation. The findings suggest that CRF has pronounced activating properties and ajfects the glutamatergic and GABAergic systems.
Complete elimination of iodine deficiency-induced diseases in the Republic of Serbia through overall salt iodination
Authors: Simic M. , Banisevic M. , Andjelkovic Z. , Zivic G. , Zikic L. , Beloglav D. , Simic D. , Gerasimov G. A. , Mishchenko B. 
Published: October 2019

The territory of Serbia has been long known to be an iodine de­ficiency area. The surveys conducted in the past 50 years have shown that iodine deficiency disorders ranged from small goiters to endemic cretinism. The iodine deficiency control program has been implemented in Serbia since 1951, in so doing, the salt con­centration of iodine (as potassium iodide) has been gradually in­creased and at present it is 20 mg/kg. Just in the mid- 1960s, io­dine prophylaxis led to cessation of new cases of cretinism and large goiters.This survey was undertaken to determine the iodine provision in Serbia. The survey was conducted in accordance with the WHO, UNICEF, and ICCIDD guidelines and it covered 4598 school­children aged 7 to 15 years from the urban and rural areas of 44 municipalities of Central Serbia and Vojvodina. Among all the examinees, the detection rate of the enlarged thyroid was 2.35% (as evidenced by ultrasound study) and the median urinary io­dine concentration was 158 μg/l. The findings suggest that iodine deficiency has been completely eliminated in Serbia due to the ef­fective program of the overall dietary salt iodination.
State-wide implementation of edTPA in preparation for high-stakes testing: A mixed-methods study of the concerns of edTPA coordinators
Authors: Many Joyce E. , Bhatnagar Ruchi , Tanguay Carla , Favors-Welch Shaneeka , Thomas Clarice , Cannon Susan Ophelia , Ogletree Tamra , Kim Jihye , Howrey Shannon , An Sohyun , Kurz Karen , Wilson Judi 
Published: October 2019

This study examined the implementation of high-stakes adoption of edTPA® in one state in the year prior to consequential use of edTPA scores for teacher licensure. Using a mixed methods design, we investigated concerns of coordinators who were responsible for edTPA implementation in their institutions. We utilized the Concerns Based Adoption Model (CBAM) to understand edTPA coordinators’ Stages of Concern, the nature of the challenges they faced, and the professional development opportunities that alleviated their concerns. Based on the CBAM survey, the most common Stage of Concernfor edTPA coordinators was Management.Coordinators’ interviews revealed the nature of their concerns at different stages and how the size of their institution and supportive resources at particular times may have played a crucial role in shaping the edTPA roll-out in their institutions. The use of the CBAM framework enabled edTPA coordinators (a) to understand their own concerns about the high-stakes policy, (b) to articulate the complexities involved in implementing edTPA initiatives, and (c) to underscore the importance of relating concerns to appropriate professional development opportunities and support for themselves as well as their faculty.
Les entrées en matière non théoriques dans des mémoires de master et des articles de revues
Authors: Daunay Bertrand , Bart Daniel 
Published: October 2019

L’article veut contribuer à la description des spécificités du discours scientifique en comparant des entrées en matière de mémoires de master d’étudiants et d’articles d’enseignants-chercheurs. Dans ces entrées en matières, est interrogée la place des références à d’autres univers que le champ théorique, ce qui constitue l’une des questions sensibles dans l’apprentissage de l’écrit académique par de jeunes chercheurs. La comparaison porte sur les items identifiés comme réalisant une référence non théorique dans un corpus de 20 mémoires de master en didactique et de 20 articles issus de 7 revues de didactique. Cette étude exploratoire présente certaines convergences formelles des références non théoriques réalisées dans les écrits des chercheurs et des étudiants mais montre une différence quant au type de référence mobilisé. Cette analyse se double d’une intention pratique, les résultats de la comparaison donnant lieu à des activités destinées à aider les apprenants à mieux identifier les attentes académiques.
Axicabtagene Ciloleucel, an Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy for Relapsed or Refractory Large B-Cell Lymphoma: Practical Implications for the Community Oncologist
Authors: Jacobson Caron A. , Farooq Umar , Ghobadi Armin 
Published: October 2019

AbstractAxicabtagene ciloleucel is the first U.S. Food and Drug Administration–approved autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for the treatment of patients with relapsed or refractory large B-cell lymphoma after ≥2 prior systemic therapies. Although axicabtagene ciloleucel is administered only at authorized treatment centers, community oncologists play a critical role in the CAR T-cell treatment journey, recognizing potentially eligible patients for referral and then, after treatment, closely collaborating with treatment centers to monitor and manage patients long term. ZUMA-1, the pivotal, multicenter, phase I/II study of 108 patients treated with axicabtagene ciloleucel, resulted in an objective response rate of 83%, including 58% complete responses. With a 27.1-month median follow-up, 39% of patients had ongoing responses. CAR T-cell therapy is associated with the potentially life-threatening adverse events (AEs) of cytokine release syndrome and neurologic events, which generally occur early after treatment. In ZUMA-1, cytokine release syndrome and neurologic events were generally reversible and grade ≥3 cytokine release syndrome and neurologic events occurred in 11% and 32% of patients, respectively. Frequent prolonged AEs included hypogammaglobulinemia, B-cell aplasia, and cytopenias requiring supportive care until recovery of hematopoietic function. Rate of treatment-related mortality was low, at &lt;2%. With appropriate management of common AEs, axicabtagene ciloleucel offers the potential for long-term durable responses in patients who otherwise lack curative treatment options.
МАЛЫЙ И СРЕДНИЙ БИЗНЕС КАК КОНСТИТУИРУЮЩАЯ ОСНОВА РАЗВИТИЯ ЭКОНОМИКИ
Authors: Сотников Станислав Михайлович , Миронова Ирина Станиславовна 
Published: October 2019

Цель: выявление роли малого и среднего предпринимательства в процессе формирования конкурентной среды и развития конкуренции в повышении эффективности общественного производства. Обсуждение: проанализированы подходы к определению параметров отнесения хозяйствующих субъектов к малому и среднему бизнесу, дана структурная характеристика таким видам деятельности, выявлены факторы, отрицательно влияющие на функционирование малых и средних предприятий, предложены основные направления по развитию малого и среднего предпринимательства. Результаты: малый и средний бизнес в своем распоряжении имеют ограниченные ресурсы. В этой связи, поддержка такого типа предприятий является необходимым условием их устойчивого развития.
ПРОСТРАНСТВЕННО-ФУНКЦИОНАЛЬНАЯ ДИНАМИКА РОССИЙСКИХ РЕГИОНОВ
Authors: Иголкин Иван Сергеевич , Трещевский Юрий Игоревич 
Published: October 2019

Цель: выявление тенденций и закономерностей динамики основных воспроизводственных показателей развития регионов, которые мы трактуем как пространственно-функциональную динамику. Обсуждение: проблема управления функциональными характеристиками регионов применительно к современной России актуализировалась в период перехода к рыночной системе хозяйствования. Однако, до начала 2000-х годов считалось, что установление необходимых пропорций и их корректировка в соответствии со спросом будет происходить автоматически. На практике этого не произошло, поэтому в начале ХХI века в стране начали формироваться представления о необходимости и способах установления рациональных экономических пропорций на национальном и региональном уровнях. В исследовании мы исходим из предпосылки, что регионы России образуют группы, различающиеся по степени сбалансированности отдельных экономических подсистем (видов деятельности). Выявить степень сбалансированности можно посредством виртуальной кластеризации. Результаты: экономическая структура российских регионов характеризуется различной степенью сбалансированности. Можно выделить пять достаточно однородных групп, различающихся по соотношению результатов различных видов деятельности. Наиболее разбалансированными являются два виде виртуальных кластеров: образованных регионами, сочетающими относительно высокие уровни развития сельского хозяйства и бюджетной сферы; диверсифицированный кластер с развитой сферой финансовых, торговых, коммунальных услуг; бюджетной сферой, производством и распределением энергии. Средним по уровню сбалансированности экономической структуры является «транспортно-энергетический» кластер. Достаточно сбалансирован кластер с промышленно-торговой специализацией, Наиболее стабильным по функциональным и пространственным характеристикам является кластер, специализирующийся на добыче полезных ископаемых.
ОЦЕНОЧНАЯ ХАРАКТЕРИСТИКА ОСНОВНЫХ СРЕДСТВ В УСЛОВИЯХ КОНКУРЕНЦИИ
Authors: Васильева Кира Николаевна 
Published: October 2019

Цель: исследование теоретических положений отнесения основных средств к основному капиталу организации и выявление разграничения понятий основных фондов, основных средств и малоценных основных средств с целью применения в хозяйственной практике конкурентной среды.
Обсуждение: определено место капитала в предметно-объектной области бухгалтерского учета; дана оценка современного понимание сущности и содержания как основных средств, но и многих других учетных объектов с экономико-теоретической, гражданско-правовой, налоговой и др. позиций.
Результаты: материалы исследования данной статьи помогут дифференцировать активы и капитал, а также аргументировано разграничить использование в практике учета основных фондов, основных средств и малоценных основных средств.
МЕТОД ПОСТРОЕНИЯ СОДЕРЖАТЕЛЬНО ИНТЕРПРЕТИРУЕМЫХ РЕГРЕССИОННЫХ МОДЕЛЕЙ В УСЛОВИЯХ МУЛЬТИКОЛЛИНЕАРНОСТИ
Authors: Мокшина Светлана Ивановна , Шуршикова Галина Владимировна , Щекунских Светлана Станиславовна 
Published: October 2019

Цель: построение линейных регрессионных моделей без искажающих содержательный смысл эффектов мультиколлинеарности. Обсуждение: вопрос эконометрического моделирования в ситуации, когда имеет место мультиколлинеарность, продолжает оставаться актуальным, несмотря на достаточно большой арсенал рекомендаций. Практически все рекомендации ориентированы на решение проблем вычислительного характера, связанных с вырожденностью матрицы нормальных уравнений. Можно считать, что проблемы вычислительного характера в основном решены. Но проблема, связанная с содержательным смыслом окончательного варианта эконометрической модели ни в одном из методов не рассматривается и, по прежнему, остается не решенной. Результаты: предлагается оригинальный способ построения линейных регрессионных моделей для случаев, когда эффекты мультиколлинеарности проявляются искажениями содержательного смысла факторного влияния на моделируемый показатель. Проведенные эмпирические исследования подтвердили эффективность предлагаемого способа.
ЭККАУНТИНГ: ВОПРОСЫ ТЕОРИИ И ПРАКТИКИ
Authors: Бреславцева Нина Александровна , Сверчкова Ольга Федоровна 
Published: October 2019

Цель: теория и практики применения приемов и методов эккаунтинга на современных российских предприятиях, как одного из перспективных направлений учета, контроля и планирования хозяйственной деятельности. Обсуждение: в настоящее время в научной и учебной литературе все чаще можно встретить термин эккаунтинг. Данное понятие рассматривается различными авторами с различных точек зрения. Одни считают, что эккаунтинг заключается исключительно в ведение бухгалтерского учета, другие добавляют к его функциям выполнение контроля. С нашей точки зрения эккаунтинг, как сфера деятельности объединяет ведение бухгалтерского учета, выполнение аудиторских процедур и, на основе полученной достоверной, отвечающей требованиям законодательства информации, осуществление планирования хозяйственной деятельности организации. Результаты: авторами обозначены группы пользователей продуктов эккаунтинга. Выделены нормативные документы, регламентирующие осуществление (реализацию) процедур эккаунтинга. Рассмотрены принципы осуществления процедур эккаунтинга, которые комплексно строятся на принципах из бухгалтерского учета, аудита и планирования. Выделены виды эккаунтинга.