bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infrared Detection of Abundant CS in the Hot Core AFGL 2591 at High Spectral Resolution with SOFIA/EXES*
Authors: Barr Andrew G. , Boogert Adwin , DeWitt Curtis N. , Montiel Edward , Richter Matthew J. , Indriolo Nick , Neufeld David A. , Pendleton Yvonne , Chiar Jean , Dungee Ryan , M. Tielens Alexander G. G. 
Published: November 2018

Abstract
We have performed a 5–8 μm spectral line survey of the hot molecular core associated with the massive protostar AFGL 2591, using the Echelon-Cross-Echelle Spectrograph (EXES) on board the Stratospheric Observatory for Infrared Astronomy (SOFIA). We have supplemented these data with a ground-based study in the atmospheric M band around 4.5 μm using the iSHELL instrument on the Infrared Telescope Facility (IRTF), and the full N-band window from 8 to 13 μm using the Texas Echelon Cross Echelle Spectrograph (TEXES) on the IRTF. Here we present the first detection of rovibrational transitions of CS in this source. The absorption lines are centered on average around −10 km s−1 and the line widths of CS compare well with the hot component of 13CO (around 10 km s−1). Temperatures for CS, hot 13CO, and 12CO v = 1–2 agree well and are around 700 K. We derive a CS abundance of 8 × 10−3 and 2 × 10−6 with respect to CO and H2, respectively. This enhanced CS abundance with respect to the surrounding cloud (1 × 10−8) may reflect sublimation of H2S ice followed by gas-phase reactions to form CS. Transitions are in local thermodynamic equilibrium and we derive a density of >107 cm−3, which corresponds to an absorbing region of <0.04″. EXES observations of CS are likely to probe deeply into the hot core, to the base of the outflow. Submillimeter and infrared observations trace different components of the hot core as revealed by the difference in systemic velocities, line widths, and temperatures, as well as the CS abundance.
Effect of cyclosporin and tacrolimus on kidney function in liver recipients
Authors: Kosmacheva Elena D. , Babich Anna E. 
Published: November 2018

Introduction. Chronic renal failure is a significant issue regarding treatment of patients after liver transplantation. One of the factors determining the impaired renal function after liver transplantation is a long-term immunosuppressive therapy based on calcineurin inhibitors. The objective of the study was to evaluate the dynamics of renal function, depending on the use of various calcineurin inhibitors in the long-term postoperative period in liver recipients in real clinical practice.
Materials and methods. A retrospective analysis of the renal function in patients operated in the State Public Health Budget Institution “Scientific Research Institute – S.V. Ochapovsky Regional Clinic Hospital № 1”, Krasnodar Region, was carried out. This article describes dynamics of creatinine level and glomerular filtration rate (GFR) in patients before liver transplant, as well as 6 months, 1, 2 and 3 years after surgery. GFR was calculated using the CKD-EPI formula (Chronic Kidney Disease Epidemiology Collaboration). Statistical processing of the results was carried out using the Statistica 10 software package.
Results and discussion. Before transplantation, the level of creatinine in the blood plasma was 82.9±19.8 mmol/l, 6 months later a20.4% increase in creatinine was registered (p=0.004), 12, 24 and 36 months later – it increased by 24.8% (p=0.00001), 24.4% (p=0.0004), and 26.0% (p=0.0005), respectively. Both cyclosporine and tacrolimus caused an increase in the level of creatinine. Baseline GFR was 83.4±25.9, the reduction in GFR occurred in comparison with the baseline by 14.2% (p=0.0005), 18.8% (p=0.00001), 20.2% (p=0.00003), 22.6% % (p=0.00006) 6, 12, 24 and 36 months later, respectively. The degree of the decrease in GFR against the background of tacrolimus therapy did not differ significantly from that in case of cyclosporine. Verification of chronic kidney disease and the administration of statins were recorded in isolated cases.
Conclusions. In liver recipients, the level of creatinine rises and GFR decreases. Reduction of kidney function occurs against the background of both inhibitors of calcineurin, in connection with which it is necessary to increase the doctors’ alertness for early detection of a decrease in glomerular filtration rate with further verification of chronic kidney disease.
Brief Exposure of Skin to Near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response
Authors: Kimizuka Yoshifumi , Katagiri Wataru , Locascio Joseph J. , Shigeta Ayako , Sasaki Yuri , Shibata Mai , Morse Kaitlyn , Sîrbulescu Ruxandra F. , Miyatake Mizuki , Reeves Patrick , Suematsu Makoto , Gelfand Jeffrey , Brauns Timothy , Poznansky Mark C. , Tsukada Kosuke , Kashiwagi Satoshi 
Published: November 2018

Abstract
The treatment of skin with a low-power continuous-wave (CW) near-infrared (NIR) laser prior to vaccination is an emerging strategy to augment the immune response to intradermal vaccine, potentially substituting for chemical adjuvant, which has been linked to adverse effects of vaccines. This approach proved to be low cost, simple, small, and readily translatable compared with the previously explored pulsed-wave medical lasers. However, little is known on the mode of laser–tissue interaction eliciting the adjuvant effect. In this study, we sought to identify the pathways leading to the immunological events by examining the alteration of responses resulting from genetic ablation of innate subsets including mast cells and specific dendritic cell populations in an established model of intradermal vaccination and analyzing functional changes of skin microcirculation upon the CW NIR laser treatment in mice. We found that a CW NIR laser transiently stimulates mast cells via generation of reactive oxygen species, establishes an immunostimulatory milieu in the exposed tissue, and provides migration cues for dermal CD103+ dendritic cells without inducing prolonged inflammation, ultimately augmenting the adaptive immune response. These results indicate that use of an NIR laser with distinct wavelength and power is a safe and effective tool to reproducibly modulate innate programs in skin. These mechanistic findings would accelerate the clinical translation of this technology and warrant further explorations into the broader application of NIR lasers to the treatment of immune-related skin diseases.
Cutting Edge: B Cells Expressing Cyclic Citrullinated Peptide–Specific Antigen Receptor Are Tolerized in Normal Conditions
Authors: Yamada Hisakata , Ozawa Tatsuhiko , Kishi Hiroyuki , Okada Seiji , Nakashima Yasuharu , Muraguchi Atsushi , Yoshikai Yasunobu 
Published: November 2018

Abstract
Generation of neoantigens by citrullination is implicated in the production of anti–citrullinated protein Abs in rheumatoid arthritis, but citrullination is also a physiological process. To verify whether citrullin-specific B cells are immunologically ignorant or tolerant in normal conditions, transgenic (Tg) mice expressing IgM with the V region of an anti–cyclic citrullinated peptide (CCP) mAb cloned from a rheumatoid arthritis patient were generated. CCP-specific B cells developed in the anti-CCP IgM Tg mice with an alteration of bone marrow B cell fractions, and the number of mature B cells decreased compared with wild-type or the control anti–influenza nucleoprotein–specific IgM Tg mice. In addition, B cells in anti-CCP IgM Tg mice are functionally anergic. Thus, tolerance is induced in CCP-specific B cells in vivo, suggesting that the immune systems are naturally exposed to citrullinated Ags, and anti-CCP Ab production requires additional steps beyond the generation of neoantigens by citrullination.
CD8α+ Dendritic Cells Dictate Leukemia-Specific CD8+ T Cell Fates
Authors: Kline Douglas E. , MacNabb Brendan W. , Chen Xiufen , Chan Wen-Ching , Fosco Dominick , Kline Justin 
Published: November 2018

Abstract
APCs are essential for the orchestration of antitumor T cell responses. Batf3-lineage CD8α+ and CD103+ dendritic cells (DCs), in particular, are required for the spontaneous initiation of CD8+ T cell priming against solid tumors. In contrast, little is known about the APCs that regulate CD8+ T cell responses against hematological malignancies. Using an unbiased approach, we aimed to characterize the APCs responsible for regulating CD8+ T cell responses in a syngeneic murine leukemia model. We show with single-cell resolution that CD8α+ DCs alone acquire and cross-present leukemia Ags in vivo, culminating in the induction of leukemia-specific CD8+ T cell tolerance. Furthermore, we demonstrate that the mere acquisition of leukemia cell cargo is associated with a unique transcriptional program that may be important in regulating tolerogenic CD8α+ DC functions in mice with leukemia. Finally, we show that systemic CD8α+ DC activation with a TLR3 agonist completely prevents their ability to generate leukemia-specific CD8+ T cell tolerance in vivo, resulting instead in the induction of potent antileukemia T cell immunity and prolonged survival of leukemia-bearing mice. Together, our data reveal that Batf3-lineage DCs imprint disparate CD8+ T cell fates in hosts with solid tumors versus systemic leukemia.
Effectiveness of Modified Constraint-Induced Movement Therapy Compared With Bimanual Therapy Home Programs for Infants With Hemiplegia: A Randomized Controlled Trial
Authors: Chamudot Rena , Parush Shula , Rigbi Amihai , Horovitz Roni , Gross-Tsur Varda 
Published: November 2018

AbstractOBJECTIVE. We examined the effectiveness of modified constraint-induced movement therapy (mCIMT) in treating infants with hemiplegic cerebral palsy and compared therapy outcomes with a nonconstraining bimanual therapy (BIM) of equal intensity.METHOD. In a single-blinded randomized controlled trial, 33 infants with hemiplegia (mean corrected age = 11.1 mo, standard deviation = 2.2) received either mCIMT (n = 17) or BIM (n = 16). Both interventions included home programs encouraging the use of the affected hand during daily 1-hr play sessions for 8 wk. Outcome measures were administered pre- and posttreatment and included the Mini-Assisting Hand Assessment for babies and the Functional Inventory. At baseline, parents also filled out the Dimensions of Mastery Questionnaire.RESULTS. Both groups demonstrated a significantly large and equal improvement in hand and gross motor function posttreatment (p &lt; .001) and high treatment compliance.CONCLUSION. mCIMT and BIM are equally effective methods for treating infants with hemiplegia.
Parallel-Forms Reliability and Clinical Utility of an Application Version of the Activity Card Sort Australia (18–64)
Authors: Gustafsson Louise , Martin Aleysha , Buijsman Liane , Poerbodipoero Soemitro , Liddle Jacki , Ireland David 
Published: November 2018

Abstract
OBJECTIVE. This study examined the parallel-forms reliability of a web application (app) of the Activity Card Sort Australia for adults ages 18–64 and assessed its clinical utility.
METHOD. Forty-eight participants completed the app and card versions of the tool within a 2- to 3-wk interval and provided feedback via a purpose-designed survey. Intraclass correlation analysis tested parallel-forms reliability.
RESULTS. The app demonstrated acceptable parallel-forms reliability for overall retained activity level (r = .75, p &lt; .001), the daily life domain (r = .77, p &lt; .001), and the recreation and relaxation domain (r = .74, p &lt; .001), but not for the physical activity domain (r = .59, p &lt; .001). Clinical utility responses suggested good acceptance of both versions.
CONCLUSION. The results suggest that further studies are required before the app version can be used for research or in clinical settings.
Effects of Free Transportation on Function, Health, and Quality of Life in Community-Dwelling Older Adults
Authors: Tomita Machiko Rachel , Schuler Erica , Moy Heidi , Sigler Julianne 
Published: November 2018

Abstract
Date Presented 4/19/2018
Two years of free transportation availability improved health, function, quality of life, and social relations and lowered depression for community-dwelling older adults.
Primary Author and Speaker: Machiko Rachel Tomita
Additional Authors and Speakers: Erica Schuler, Heidi Moy, Julianne Sigler
Development and Translation of Measurement Findings for the Motivation Assessment for Team Readiness, Integration, and Collaboration Self-Scoring Form
Authors: Liu John 
Published: November 2018

Abstract
Date Presented 4/19/2018
The Motivation Assessment for Team Readiness, Integration, and Collaboration provides information on intrapersonal readiness to collaborate in a team. The study aimed to develop an innovative approach to assessing and interpreting individual motivation in collaborative biomedical teams.
Primary Author and Speaker: John Liu Jr.
Contributing Authors: Gaetano Lotrecchiano, Trudy Mallinson, Lisa Schwartz, Holly Falk-Krzesinski
The Role of Everyday Technology and Engagement in Activities in Perceived Health Among Older People in Urban Communities
Authors: Kottorp Anders , Lee Jenica , Walsh Ryan J 
Published: November 2018

Abstract
Date Presented 4/19/2018
This study of older people with and without functional limitations in an urban environment targeted everyday technology access and use, activity engagement, cognition, and perceived health.
Primary Author and Speaker: Anders Kottorp
Additional Authors and Speakers: Jenica Lee, Ryan J. Walsh
Contributing Authors: Ruxandra Drasga, Caniece Leggett, Holly Schapnik
Effects of Alternative Seating on Attention and In-Seat Behavior for Children With Autism
Authors: Morgus Kristen , Benson Jeryl , Brown Elena Donoso , Smitsky Deborah 
Published: November 2018

Abstract
Date Presented 4/19/2018
The purpose of this study was to determine the effects of alternative seating on attention and in-seat behavior of preschoolers with autism. Preliminary results indicate that alternative seating was effective in improving attention. Results advance the profession as school therapists may recommend alternative seating.
Primary Author and Speaker: Kristen Morgus
Additional Authors and Speakers: Jeryl Benson, Elena Donoso Brown, and Deborah Smitsky
What Is the Meaning of Occupational Therapy for Patients With Left Ventricular Assist Devices in Acute Care?
Authors: Wyble Elizabeth 
Published: November 2018

Abstract
Date Presented 4/19/2018
Patients with left ventricular assist devices (LVADs) are growing in number. This study provides the first evidence to support that patients perceive occupational therapy interventions to be meaningful and beneficial during acute care hospitalization after LVAD implantation.
Primary Author and Speaker: Elizabeth Wyble
Contributing Authors: Lisa Borrero, Jennifer Fogo, Cheryl Bittel, Katie Caldwell, Deborah Mann
(ADED) Interim Findings of a Randomized Controlled Trial: Driving Intervention for Returning Combat Veterans
Authors: Classen Sherrilene , Winter Sandra 
Published: November 2018

Abstract
Date Presented 4/20/2018
Returning combat veterans are at increased risk for motor vehicle collisions, injuries, and deaths. This poster describes the steps in a program of research that are critical for conducting a clinical trial to assess the effectiveness of an occupational therapy driving intervention.
Primary Author and Speaker: Sherrilene Classen
Additional Authors and Speakers: Sandra Winter
Facilitating the Participation of Older Adults Using an Occupation-Based Community Mobility Program: A Mixed Methods Study
Authors: Mulry Claire M. 
Published: November 2018

Abstract
Date Presented 4/20/2018
Community participation has been linked to health and well-being and is a research priority. This study examined the outcomes of a community mobility program for older adults. Participants in the single-group, pretest–posttest, mixed methods design study demonstrated increased community participation and confidence.
Primary Author and Speaker: Claire M. Mulry
Contributing Authors: Mark Ravinsky, Christina Papetti, Julian DeMartinis
Relationships Between Therapist and Client Actions During Sensory Integration Therapy for Young Children With Autism
Authors: Holland Cristin , Yay Ozan , Gallini Giorgio , Blanche Erna , Thompson Barbara 
Published: November 2018

Abstract
Date Presented 4/20/2018
This study explored relationships between child and therapist behaviors during sensory integration therapy. Data reveal strong correlations between behaviors children improved in and specific therapist activities, which can guide sensory integration therapy for young clients with autism to improve child outcomes.
Primary Author and Speaker: Cristin Holland
Additional Authors and Speakers: Ozan Yay, Giorgio Gallini, Erna Blanche, Barbara Thompson
Correlation Between Therapeutic Use of Self and Clients’ Participation in Rehabilitation
Authors: Fan Chia-Wei , Taylor Renee 
Published: November 2018

Abstract
Date Presented 4/20/2018
The Model of Human Occupation Screening Tool (MOHOST) and the Clinical Assessment of Modes were used to evaluate clients’ participation and paired therapists’ use of mode. Correlation analyses were conducted. The results show that the empathizing mode was significantly correlated to five subdomains of the MOHOST.
Primary Author and Speaker: Chia-Wei Fan
Additional Authors and Speakers: Renee Taylor
Student Book Bag Weight, Carriage Habits, and Perceptions of Pain, Participation, and Quality of Life
Authors: Prager Eliza , Guimbarda Anna , Hentis Torey , Hill Allie , Huxel Trisha , Massey Kayla , Wecke Katie 
Published: November 2018

Abstract
Date Presented 4/20/2018
More than 60% of college students carry book bags greater than 10% of their body weight. However, we found that book bag weight was not correlated with pain, limitations in participation, or decreased quality of life. We look to the literature for factors that may influence these outcomes.
Primary Author and Speaker: Eliza Prager
Additional Authors and Speakers: Anna Guimbarda, Torey Hentis, Allie Hill, Trisha Huxel, Kayla Massey, Katie Wecke
The CALIPSO version 4 automated aerosol classification and lidar ratio selection algorithm
Authors: Kim Man-Hae , Omar Ali H. , Tackett Jason L. , Vaughan Mark A. , Winker David M. , Trepte Charles R. , Hu Yongxiang , Liu Zhaoyan , Poole Lamont R. , Pitts Michael C. , Kar Jayanta , Magill Brian E. 
Published: November 2018

Abstract. The Cloud-Aerosol Lidar with Orthogonal Polarization
(CALIOP) version 4.10 (V4) level 2 aerosol data products, released in
November 2016, include substantial improvements to the aerosol subtyping and
lidar ratio selection algorithms. These improvements are described along
with resulting changes in aerosol optical depth (AOD). The most fundamental
change in the V4 level 2 aerosol products is a new algorithm to identify aerosol
subtypes in the stratosphere. Four aerosol subtypes are introduced for
stratospheric aerosols: polar stratospheric aerosol (PSA), volcanic ash,
sulfate/other, and smoke. The tropospheric aerosol subtyping algorithm was
also improved by adding the following enhancements: (1) all aerosol subtypes
are now allowed over polar regions, whereas the version 3 (V3) algorithm
allowed only clean continental and polluted continental aerosols; (2) a new
“dusty marine” aerosol subtype is introduced, representing mixtures of
dust and marine aerosols near the ocean surface; and (3) the “polluted
continental” and “smoke” subtypes have been renamed “polluted
continental/smoke” and “elevated smoke”, respectively. V4 also revises
the lidar ratios for clean marine, dust, clean continental, and elevated
smoke subtypes. As a consequence of the V4 updates, the mean 532 nm AOD
retrieved by CALIOP has increased by 0.044 (0.036) or 52 % (40 %) for
nighttime (daytime). Lidar ratio revisions are the most influential factor
for AOD changes from V3 to V4, especially for cloud-free skies. Preliminary
validation studies show that the AOD discrepancies between CALIOP and
AERONET–MODIS (ocean) are reduced in V4 compared to V3.
Spectral Intensity Bioaerosol Sensor (SIBS):
A new Instrument for Spectrally Resolved Fluorescence
Detection of Single Particles in Real-Time
Authors: Könemann Tobias , Savage Nicole , Klimach Thomas , Walter David , Fröhlich-Nowoisky Janine , Su Hang , Pöschl Ulrich , Huffman Alex , Pöhlker Christopher 
Published: November 2018

Abstract. Primary biological aerosol particles (PBAP) in the atmosphere are highly relevant for the Earth system, climate, and public health. The analysis of PBAP, however, remains challenging due to their high diversity and large spatiotemporal variability. For real-time PBAP analysis, light-induced fluorescence (LIF) instruments have been developed and widely used in laboratory and ambient studies. The interpretation of fluorescence data from these instruments, however, is often limited by a lack of spectroscopic information. This study introduces a new instrument – the Spectral Intensity Bioaerosol Sensor (SIBS) – that resolves fluorescence spectra for single particles and, thus, promises to expand the scope of fluorescent PBAP quantification and classification. The SIBS shares key design components with the latest versions of the Wideband Integrated Bioaerosol Sensor (WIBS) and the findings presented here are also relevant for the widely deployed WIBS-4A and WIBS-NEO as well as other LIF instruments. The key features of the SIBS and findings of this study can be summarized as follows: –	Particle sizing yields reproducible linear responses for particles in the range of 300 nm to 20 µm. The lower sizing limit is significantly smaller than for earlier commercial LIF instruments (e.g., WIBS-4A and the Ultraviolet Aerodynamic Particle Sizer (UV-APS)), expanding the analytical scope into the accumulation mode size range. – Fluorescence spectra are recorded for two excitation wavelengths (λex = 285 and 370 nm) and a wide range of emission wavelengths (λmean = 302–721 nm) with a resolution of 16 detection channels, which is higher than for most other commercially available LIF bioaerosol sensors. – Fluorescence spectra obtained for 16 reference compounds confirm that the SIBS provides sufficient spectral resolution to distinguish major modes of molecular fluorescence. For example, the SIBS resolves the spectral difference between bacteriochlorophyll and chlorophyll a/b. –	A spectral correction of the instrument-specific detector response is essential to use the full fluorescence emission range. –	Asymmetry factor (AF) data were assessed and were found to provide only limited analytical information. –	In test measurements with ambient air, the SIBS worked reliably and yielded characteristically different spectra for single particles in the coarse mode with an overall fluorescent particle fraction of ~ 4 % (3σ threshold), which is consistent with earlier studies in comparable environments.