bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventing dementia by preventing stroke: The Berlin Manifesto
Authors: Hachinski Vladimir , Einhäupl Karl , Ganten Detlev , Alladi Suvarna , Brayne Carol , Stephan Blossom C.M. , Sweeney Melanie D. , Zlokovic Berislav , Iturria‐Medina Yasser , Iadecola Costantino , Nishimura Nozomi , Schaffer Chris B. , Whitehead Shawn N. , Black Sandra E. , Østergaard Leif , Wardlaw Joanna , Greenberg Steven , Friberg Leif , Norrving Bo , Rowe Brian , Joanette Yves , Hacke Werner , Kuller Lewis , Dichgans Martin , Endres Matthias , Khachaturian Zaven S. 
Published: July 2019

AbstractThe incidence of stroke and dementia are diverging across the world, rising for those in low‐ and middle‐income countries and falling in those in high‐income countries. This suggests that whatever factors cause these trends are potentially modifiable. At the population level, neurological disorders as a group account for the largest proportion of disability‐adjusted life years globally (10%). Among neurological disorders, stroke (42%) and dementia (10%) dominate. Stroke and dementia confer risks for each other and share some of the same, largely modifiable, risk and protective factors. In principle, 90% of strokes and 35% of dementias have been estimated to be preventable. Because a stroke doubles the chance of developing dementia and stroke is more common than dementia, more than a third of dementias could be prevented by preventing stroke. Developments at the pathological, pathophysiological, and clinical level also point to new directions. Growing understanding of brain pathophysiology has unveiled the reciprocal interaction of cerebrovascular disease and neurodegeneration identifying new therapeutic targets to include protection of the endothelium, the blood‐brain barrier, and other components of the neurovascular unit. In addition, targeting amyloid angiopathy aspects of inflammation and genetic manipulation hold new testable promise. In the meantime, accumulating evidence suggests that whole populations experiencing improved education, and lower vascular risk factor profiles (e.g., reduced prevalence of smoking) and vascular disease, including stroke, have better cognitive function and lower dementia rates. At the individual levels, trials have demonstrated that anticoagulation of atrial fibrillation can reduce the risk of dementia by 48% and that systolic blood pressure lower than 140 mmHg may be better for the brain. Based on these considerations, the World Stroke Organization has issued a proclamation, endorsed by all the major international organizations focused on global brain and cardiovascular health, calling for the joint prevention of stroke and dementia. This article summarizes the evidence for translation into action.
The relative efficiency of time‐to‐progression and continuous measures of cognition in presymptomatic Alzheimer's disease
Authors: Li Dan , Iddi Samuel , Aisen Paul S. , Thompson Wesley K. , Donohue Michael C. ,   Alzheimer's Disease Neuroimaging Initiative
Published: July 2019

AbstractIntroductionClinical trials on preclinical Alzheimer's disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more efficiently than models of time to progression.MethodsMultivariate continuous data are simulated from a Bayesian joint mixed‐effects model fit to data from the Alzheimer's Disease Neuroimaging Initiative. Simulated progression events are algorithmically derived from the continuous assessments using a random forest model fit to the same data.ResultsWe find that power is approximately doubled with models of repeated continuous outcomes compared with the time‐to‐progression analysis. The simulations also demonstrate that a plausible informative missing data pattern can induce a bias that inflates treatment effects, yet 5% type I error is maintained.DiscussionGiven the relative inefficiency of time to progression, it should be avoided as a primary analysis approach in clinical trials of preclinical Alzheimer's disease.
How to implement a robust BCDR plan
Authors: Weeks Ryan 
Published: July 2019

Ransomware remains a problem and businesses in Europe are now suffering more from ransomware attacks than their global counterparts. For example, a recent survey among managed service providers (MSPs) found that 42% of European MSPs saw their small and medium-sized clients suffer multiple attacks in a single day. 1 This was higher than the global average of 35%. Ransomware remains a problem and businesses in Europe are now suffering more from ransomware attacks than their global counterparts. Such attacks can be crippling and are spreading to the cloud. It is essential for organisations to implement a solid business continuity and disaster recovery (BCDR) plan to minimise any risk of system downtime and loss of sensitive information, but they should also be aware there is no single ‘right’ approach, explains Ryan Weeks of Datto.
Detection of S-100β Protein in Plasma and Urine After a Mild Traumatic Brain Injury
Authors: Le Sage Natalie , Tardif Pier-Alexandre , Frenette Jérôme , Émond Marcel , Chauny Jean-Marc , Moore Lynne , Archambault Patrick , Perry Jeffrey , Boulanger-Piette Antoine 
Published: July 2019

ABSTRACT:This study assessed whether S-100β protein could be measured in urine when detectable in plasma after a mild traumatic brain injury (mTBI). Clinical data, plasma and urine samples were collected for the 46 adult patients prospectively enrolled in the emergency department (ED) of a Level 1 trauma center. S-100β protein concentrations were analysed using ELISA. S-100β protein was detectable in 91% and 71% of plasma and urine samples, but values were not correlated (r = 0.002). Urine sampling would have been a non-invasive procedure, but it does not appear to be useful in the ED during the acute phase after an mTBI.
Online, cross-disciplinary team science training for health and medical professionals: Evaluation of COALESCE (teamscience.net)
Authors: Spring Bonnie , Klyachko Ekaterina A. , Rak Phillip W. , McFadden H. Gene , Hedeker Donald , Siddique Juned , Bardsley Leland R. , Pfammatter Angela Fidler 
Published: July 2019

AbstractIntroduction:The National Academies of Sciences (NAS) emphasize the need for interdisciplinary team science (TS) training, but few training resources are available. COALESCE, an open-access tool developed with National Institutes of Health support and located at teamscience.net, is considered a gold standard resource but has not previously been evaluated. COALESCE launched four learning modules in 2011. The Science of TS (SciTS) module, an interactive encyclopedia, introduces foundational concepts. Three scenario-based modules simulate TS challenges in behavioral, clinical, and basic biomedical sciences. This study examined user characteristics, usage patterns, and effects of completing the four modules on TS knowledge, attitudes, and skills.Methods:Repeated measures ANOVA tested for pre-post changes in performance and compared learning by users with biomedical versus other disciplinary backgrounds.Results:From 2011 through 2017, the site attracted 16,280 new users who engaged in 6461 sessions that lasted more than 1 min. The modal registrant identified as working in a biomedical field (47%), in an academic institution (72%), and expressed greater interest in the practice than the SciTS (67%). Those completing pre- and post-tests (n = 989) showed significant improvement in knowledge, attitudes, and skills after taking all scenario-based modules (p < 0.005); knowledge and attitudes were unchanged after the SciTS encyclopedia. Biomedical and other health professionals improved comparably.Conclusion:Evaluation of the TS training tool at teamscience.net indicates broad dissemination and positive TS-related outcomes. Site upgrades implemented between 2018 and 2020, including adding five new modules, are expected to increase the robustness and accessibility of the COALESCE training resource.
Mining the Past: A Report of Four Archival Repositories in Zambia
Authors: Munene Hyden 
Published: July 2019

Abstract:Researchers and scholars have written on the history of mining in Zambia using a variety of sources and archives. But much of the history written from local archives has relied heavily on the National Archives of Zambia. Yet, important archival holdings for researchers of the history of Zambia’s mining industry also exist in the Zambia Consolidated Copper Mines Archive, the United National Independence Party Archive, and in the Mineworkers’ Union of Zambia Headquarters. These repositories house rich collections of data invaluable for understanding Zambia’s mining industry. Covering the period from the 1890s to the present, these archives make possible new questions and interpretations of Zambia’s mining industry.
Nutrient intake is a predictor of lung function in obese asthmatic adolescents undergoing interdisciplinary therapy
Authors: Rodrigues Lydiane C. , Mota João F. , Corgosinho Flávia C. , Masquio Deborah C. L. , Dâmaso Ana R. , Tufik Sérgio , de Mello Marco T. , Cheik Nádia C. , da Silva Agostinho Patrícia L. 
Published: July 2019

AbstractAsthma-obesity is a multifactorial disease with specific asthma phenotypes that aggravate due to overweight and an unbalanced diet. Furthermore, obese asthmatic patients are corticotherapy-resistant. Therefore, the aims of the present study were to evaluate the effects of an interdisciplinary intervention on food consumption, body composition, lung function and adipokines in asthmatic and non-asthmatic obese adolescents and to investigate the influence of nutrients on lung function. Obese non-asthmatic (n 42) and obese asthmatic (n 21) adolescents of both sexes were enrolled in the present study. Food intake, adipokine levels, body composition, asthma symptoms and lung function were assessed across the study. After the intervention of 1 year, there was a reduction (P ≤ 0·01) in BMI, body fat percentage, visceral and subcutaneous fat and an increase (P ≤ 0·01) in lean mass and all lung function variables in both groups, except the relation between forced expiratory volume in 1 s and forced vital capacity (FEV1:FVC) in non-asthmatic patients. Moreover, both groups decreased lipid and cholesterol consumption (P ≤ 0·01). The highest energy consumption (β = −0·021) was associated with lower values of FVC. Similarly, carbohydrate consumption (β = −0·06) and cholesterol were negative predictors (β = −0·05) in FEV1:FVC. However, the consumption of Ca (β = 0·01), fibres (β = 1·34) and vitamin A (β = 0·01) were positive predictors of FEV1:FVC. Asthma-obesity interdisciplinary treatment promoted an improvement on food consumption and lung function in adolescents and demonstrated that the consumption of nutrients influenced an increase in lung function.
What Motivates an Oligarchic Elite to Democratize? Evidence from the Roll Call Vote on the Great Reform Act of 1832
Authors: Aidt Toke S. , Franck Raphaël 
Published: July 2019

AbstractThe Great Reform Act of 1832 was a watershed for democracy in Great Britain. We study the vote on 22 March 1831 in the House of Commons to test three competing theories of democratization: public opinion, political expedience, and threat of revolution. Peaceful agitation and mass-support for reform played an important role. Political expedience also motivated some members of Parliament to support the reform, especially if they were elected in constituencies located in counties that would gain seats. Violent unrest in urban but not in rural areas had some influence on the members of Parliament. Counterfactual scenarios suggest that the reform bill would not have obtained a majority in the House of Commons in the absence of these factors.
Work-related musculoskeletal symptoms in otorhinolaryngology and their relationship with physical activity. A nationwide survey
Authors: Lobo D , Gandarillas M A , Sánchez-Gómez S , Megía R 
Published: July 2019

AbstractObjectiveThe main objective of this study was to determine the prevalence of work-related musculoskeletal symptoms in otolaryngology and head and neck surgery specialists and trainees in Spain, and to measure the effect that physical exercise could have on muscular discomfort.MethodA cross-sectional survey was administered between September and December 2017 to practising otolaryngologists.ResultsFour hundred and three ENT surgeons responded, with a median age of 44.9 years, and 89.8 per cent reported discomfort or physical symptoms that they attributed to surgical practice. More female surgeons reported musculoskeletal symptoms (92.8 per centvs87.1 per cent;p= 0.04). When the level of physical activity was compared with the frequency of physical discomfort, no significant difference was found.ConclusionThis study has shown a high prevalence of musculoskeletal disorders among ENT surgeons in Spain but has failed to demonstrate an important role of physical exercise in the prevention of musculoskeletal disorders.
Listening to People: Using Social Psychology to Spotlight an Overlooked Virtue
Authors: Notess Susan E 
Published: July 2019

AbstractI offer a novel interdisciplinary approach to understanding the communicative task of listening, which is under-theorised compared to its more conspicuous counterpart, speech. By correlating a Rylean view of mental actions with a virtue ethical framework, I show listeners’ internal activity as a morally relevant feature of how they treat people. The listener employs a policy of responsiveness in managing the extent to which they allow a speaker's voice to be centred within their more effortful, engaged attention. A just listener's policy of responsiveness avoids unwarrantedly dismissing speakers’ messages on the basis of peripheral attention alone.
Above and beyond the concrete: The diverse representational substrates of the predictive brain
Authors: Gilead Michael , Trope Yaacov , Liberman Nira 
Published: July 2019

AbstractIn recent years, scientists have increasingly taken to investigate the predictive nature of cognition. We argue that prediction relies on abstraction, and thus theories of predictive cognition need an explicit theory of abstract representation. We propose such a theory of the abstract representational capacities that allow humans to transcend the “here-and-now.” Consistent with the predictive cognition literature, we suggest that the representational substrates of the mind are built as ahierarchy, ranging from the concrete to the abstract; however, we argue that there are qualitative differences between elements along this hierarchy, generating meaningful, often unacknowledged,diversity.Echoing views from philosophy, we suggest that the representational hierarchy can be parsed into:modality-specificrepresentations, instantiated on perceptual similarity;multimodalrepresentations, instantiated primarily on the discovery of spatiotemporal contiguity; andcategoricalrepresentations, instantiated primarily on social interaction. These elements serve as the building blocks ofcomplex structures discussed in cognitive psychology (e.g., episodes, scripts) and are the inputs for mental representations that behave like functions, typically discussed in linguistics (i.e.,predicators). We support our argument for representational diversity by explaining how the elements in our ontology are all required to account for humans’ predictive cognition (e.g., in subserving logic-based prediction; in optimizing the trade-off between accurate and detailed predictions) and by examining how the neuroscientific evidence coheres with our account. In doing so, we provide a testable model of the neural bases of conceptual cognition and highlight several important implications to research on self-projection, reinforcement learning, and predictive-processing models of psychopathology.
Cognitive decline and distinction: a new line of fracture in later life?
Authors: Libert Sébastien , Charlesworth Georgina , Higgs Paul 
Published: July 2019

AbstractCognitive decline and dementia have become major concerns for many individuals reaching later life within contemporary Western societies. This fear of decline is central to the social divide between the third age embodying ideals of maintained health, activity and lifestyle choices, and the fourth age, a social imaginary encompassing the irreversible decline associated with ageing. In this article, we explore how brain-training technologies have become successful by relying on tensions between the third and fourth ages. We review current debates on the concepts contained in brain training and examine the emphasis on the moral virtue of ‘training the brain’ in later life as an extension of fitness and health management. We underline the limited consideration given to social positioning within old age itself in the literature. We further argue that using brain-training devices can support a distancing from intimations of dementia; a condition associated with an ‘ageing without agency’. Drawing on Bourdieu, we use the concept of distinction to describe this process of social positioning. We discuss the impact that such ‘technologies of distinction’ can have on people with dementia by ‘othering’ them. We conclude that the issue of distinction within later life, particularly within the field of cognitive decline, is an important aspect of the current culture of active cognitive ageing.
Ageing in extra-care housing: preparation, persistence and self-management at the boundary between the third and fourth age
Authors: Johnson Eleanor K. , Cameron Ailsa , Lloyd Liz , Evans Simon , Darton Robin , Smith Randall , Atkinson Teresa , Porteus Jeremy 
Published: July 2019

AbstractExtra-care housing (ECH) has been hailed as a potential solution to some of the problems associated with traditional forms of social care, since it allows older people to live independently, while also having access to care and support if required. However, little longitudinal research has focused on the experiences of residents living in ECH, particularly in recent years. This paper reports on a longitudinal study of four ECH schemes in the United Kingdom. Older residents living in ECH were interviewed four times over a two-year period to examine how changes in their care needs were encountered and negotiated by care workers, managers and residents themselves. This paper focuses on how residents managed their own changing care needs within the context of ECH. Drawing upon theories of the third and fourth age, the paper makes two arguments. First, that transitions across the boundary between the third and fourth age are not always straightforward or irreversible and, moreover, can sometimes be resisted, planned-for and managed by older people. Second, that operational practices within ECH schemes can function to facilitate or impede residents’ attempts to manage this boundary.
Attitudes, knowledge and beliefs about dementia: focus group discussions with Pakistani adults in Karachi and Lahore
Authors: Farina Nicolas , Zaidi Asghar , Willis Rosalind , Balouch Sara 
Published: July 2019

AbstractPakistan is a lower middle-income country, which to date has had very little research and policy making to address the challenge of dementia. This study aims to explore the perceptions of dementia in a group of Pakistani adults. A series of focus group discussions were completed during 2017 with men and women in two metropolitan centres in Pakistan (Lahore and Karachi) (N = 40). Two vignettes, depicting someone with mild dementia and someone with severe dementia, were used to facilitate discussions. An induction-led thematic analysis was completed. Five themes were identified, reflecting (a) dementia awareness, (b) responsibility, (c) barriers to health care, (d) identified support needs, and (e) religion. Most participants had little awareness and knowledge about dementia, commonly understood to be a disease of forgetting or just normal ageing. Thus, there is an urgent need of a nation-wide campaign to raise dementia awareness in Pakistan, though this needs to be accompanied by improved, accessible health and social care services.
Path Planning Aware of Robot’s Center of Mass for Steep Slope Vineyards
Authors: Santos Luís , Santos Filipe , Mendes Jorge , Costa Pedro , Lima José , Reis Ricardo , Shinde Pranjali 
Published: July 2019

SummarySteep slope vineyards are a complex scenario for the development of ground robots. Planning a safe robot trajectory is one of the biggest challenges in this scenario, characterized by irregular surfaces and strong slopes (more than 35°). Moving the robot through a pile of stones, spots with high slope or/and with wrong robot yaw may result in an abrupt fall of the robot, damaging the equipment and centenary vines, and sometimes imposing injuries to humans. This paper presents a novel approach for path planning aware of center of mass of the robot for application in sloppy terrains. Agricultural robotic path planning (AgRobPP) is a framework that considers the A* algorithm by expanding inner functions to deal with three main inputs: multi-layer occupation grid map, altitude map and robot’s center of mass. This multi-layer grid map is updated by obstacles taking into account the terrain slope and maximum robot posture. AgRobPP is also extended with algorithms for local trajectory replanning during the execution of a trajectory that is blocked by the presence of an obstacle, always assuring the safety of the re-planned path. AgRobPP has a novel PointCloud translator algorithm called PointCloud to grid map and digital elevation model (PC2GD), which extracts the occupation grid map and digital elevation model from a PointCloud. This can be used in AgRobPP core algorithms and farm management intelligent systems as well. AgRobPP algorithms demonstrate a great performance with the real data acquired from AgRob V16, a robotic platform developed for autonomous navigation in steep slope vineyards.
Pastoral production is associated with increasedpeste des petits ruminantsseroprevalence in northern Tanzania across sheep, goats and cattle
Authors: Herzog C. M. , de Glanville W. A. , Willett B. J. , Kibona T. J. , Cattadori I. M. , Kapur V. , Hudson P. J. , Buza J. , Cleaveland S. , Bjørnstad O. N. 
Published: July 2019

AbstractPeste des petits ruminantsvirus (PPRV) causes a contagious disease of high morbidity and mortality in small ruminant populations globally. Using cross-sectional serosurvey data collected in 2016, our study investigated PPRV seroprevalence and risk factors among sheep, goats and cattle in 20 agropastoral (AP) and pastoral (P) villages in northern Tanzania. Overall observed seroprevalence was 21.1% (95% exact confidence interval (CI) 20.1–22.0) with 5.8% seroprevalence among agropastoral (95% CI 5.0–6.7) and 30.7% among pastoral villages (95% CI 29.3–32.0). Seropositivity varied significantly by management (production) system. Our study applied the catalytic framework to estimate the force of infection. The associated reproductive numbers (R0) were estimated at 1.36 (95% CI 1.32–1.39), 1.40 (95% CI 1.37–1.44) and 1.13 (95% CI 1.11–1.14) for sheep, goats and cattle, respectively. For sheep and goats, these R0values are likely underestimates due to infection-associated mortality. Spatial heterogeneity in risk among pairs of species across 20 villages was significantly positively correlated (R2: 0.59–0.69), suggesting either cross-species transmission or common, external risk factors affecting all species. The non-negligible seroconversion in cattle may represent spillover or cattle-to-cattle transmission and must be investigated further to understand the role of cattle in PPRV transmission ahead of upcoming eradication efforts.