bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineered Polymeric Carbon Nitride for Photocatalytic Diverse Functionalization of Electronic‐Rich Alkenes
Authors: Yang Youqing , Shi Jiwei , Liu Chenguang , Liu Qiong , Yang Jian , Tong Xiaogang , Lu Jiong , Wu Jie 
Published: November 2024

AbstractEngineered polymeric carbon nitride represents a promising class of metal‐free semiconductor photocatalysts for organic synthesis. Herein, we utilized engineered polymeric carbon nitride nanosheets, which exhibit an increased specific surface area and band gap due to enhanced quantum confinement from vacancy enrichment. These nanosheets serve as a heterogeneous organic semiconductor photocatalyst to facilitate diverse functionalizations of electron‐rich alkenes, including arylsulfonylation, aminodifluoroalkylation, and oxytrifluoromethylation. This catalytic system operates under mild conditions, offering excellent functional group compatibility and high yields. Additionally, the catalyst demonstrates outstanding recyclability and efficiency in flow reactors, highlighting its significant potential for industrial applications.
Multiple Redox‐Active Centers in An Azatriangulenetrione‐Based Covalent Organic Framework for High‐Capacity, High‐Rate and Ultra‐Stable Sodium‐Ion Batteries
Authors: Kang Fangyuan , Yan Lei , Chen Zihao , Zhang Yuchan , Gu Qianfeng , Yang Jinglun , Xu Shen , Wang Xiang , Lee Chun‐Sing , Wang Yonggang , Zhang Qichun 
Published: November 2024

AbstractSodium‐ion batteries (SIBs) suffer from sluggish kinetics, large volume change, and limited specific capacity due to the large radius of Na+. These issues can be solved through using covalent organic frameworks (COFs) as electrodes. Herein, an azatriangulenetrione‐containing COF (denoted as CityU‐33) was designed and synthesized as an electrode material for SIBs. Due to its inherent abundance of multiple redox‐active sites and fast intercalation kinetics, CityU‐33 delivered a high discharge capacity of 410.4 mAh g−1 at 0.1 A g−1 and showed remarkable long‐term cycling stability, where a discharge capacity of 288 mAh g−1 at 0.2 A g−1 with 97 % retention over 2000 cycles was achieved, making it the top COF electrode material for SIBs.
Ru0.1Mn0.9Ox Electrocatalyst for Durable Oxygen Evolution in Acid Seawater
Authors: Xu Jun , Kao Chun‐Chuan , Shen Haifeng , Liu Hao , Zheng Yao , Qiao Shi‐Zhang 
Published: November 2024

AbstractCurrently, direct electrolysis of seawater for green hydrogen production is primarily focused on neutral and alkaline systems. However, the precipitation of calcium and magnesium ions restricts the advancement of this technology. An acidic system can effectively address this issue. Given that Ru/Ir‐based catalysts with high oxygen evolution reaction (OER) activity also exhibit high chlorine evolution reaction (CER) activity, acid seawater splitting requires anodes with higher selectivity and stability compared to the other two systems. In this study, we propose a non‐precious Ru0.1Mn0.9Ox as the active anode for direct acid seawater electrolysis, which exhibits a high OER selectivity and remarkable stability for more than 1200 hours. Different from the Cl−‐free system, *Cl occupied on Ru sites could shift the OER active center to Mn on Ru0.1Mn0.9Ox, which prevents the lattice oxygen consumed on Ru and hinders the metal site dissolution. As the CER‐insensitive catalytic center, Mn activated by the introduction of Ru can adsorb a substantial amount of *OH, creating an OER‐favored local environment that inhibits CER. We introduce Cl−‐assisted transfer of OER active sites to CER‐insensitive Mn as a fundamental strategy for achieving highly selective and durable oxygen evolution in acidic seawater.
A Helical Tubular Dyad of [9]Cycloparaphenylene: Synthesis, Chiroptical Properties and Post‐Functionalization
Authors: Li Gaolei , Mao Liang‐Liang , Gao Jia‐Nan , Shi Xueliang , Huo Zi‐Ye , Yang Jingxuan , Zhou Wen , Li Hongwei , Yang Hai‐Bo , Tung Chen‐Ho , Wu Li‐Zhu , Cong Huan 
Published: November 2024

AbstractThe bottom‐up synthesis of discrete tubular molecules that mimic the structural features of carbon nanotubes has been a long‐standing pursuit for synthetic chemists. As the shortest segments of armchair‐type carbon nanotubes, cycloparaphenylenes are regarded as ideal macrocyclic building blocks for achieving this goal. Here we report the synthesis of a helical tubular molecule featuring three diyne linkers between two site‐specifically functionalized [9]cycloparaphenylenes. Its C3‐symmetrical, radially conjugated structure and solid‐state packing have been elucidated by spectroscopic and crystallographic characterizations. Notably, the resolved enantiomers display a circularly polarized luminescence brightness value of 1.47×103 M−1 cm−1, which is among the highest values for chiral organic molecules. Furthermore, the diyne‐linked molecule could be directly converted into a thiophene‐linked helical molecule, demonstrating the post‐functionalization approach for the construction of chiral tubular molecules from cycloparaphenylenes.
Reversible and Ultrasensitive Detection of Nitric Oxide Using a Conductive Two‐Dimensional Metal–Organic Framework
Authors: Noh Hyuk‐Jun , Pennington Doran L. , Seo Jeong‐Min , Cline Evan , Benedetto Georganna , Baek Jong‐Beom , Hendon Christopher H. , Mirica Katherine A. 
Published: November 2024

AbstractThis paper describes the use of a highly crystalline conductive 2D copper3(hexaiminobenzene)2 (Cu3(HIB)2) as an ultrasensitive (limit of detection of 1.8 part‐per‐billion), highly selective, reversible, and low power chemiresistive sensor for nitric oxide (NO) at room temperature. The Cu3(HIB)2‐based sensors retain their sensing performance in the presence of humidity, and exhibit strong signal enhancement towards NO over other highly toxic reactive gases, such as NO2, H2S, SO2, NH3, CO, as well as CO2. Mechanistic investigations of the Cu3(HIB)2‐NO interaction through spectroscopic analyses and density functional theory revealed that the Cu‐bis(iminobenzosemiquinoid) moieties serve as the binding sites for NO sensing, while the Ni‐bis(iminobenzosemiquinoid) MOF analog shows no noticeable response to NO. Overall, these findings provide a significant advance in the development of crystalline metal‐bis(iminobenzosemiquinoid)‐based conductive 2D MOFs as highly sensitive, selective, and reversible sensing materials for the low‐power detection of toxic gases.
Focused anatomy workshops for clerkships and the USMLE Step 1 examination
Authors: Ricci Anna , Minearo Ian , Hielscher Abigail 
Published: November 2024

AbstractAnatomy is essential for understanding healthy and disease states as well as for the successful completion of clinical clerkships and board examinations. This project provided structured workshops aimed to review anatomical concepts for clerkships and Step 1 and provided a means for medical students to assess their anatomical knowledge. We provided six optional anatomy workshops, in which students (1) took a pre‐session quiz, (2) faculty reviewed key anatomy of a particular system (e.g., musculoskeletal), (3) students worked through clinical cases in small groups, and (4) students took a post‐session quiz and responded to a post‐session survey to rate satisfaction of session content and delivery on a five‐point Likert scale. One session was excluded due to small sample size (n = 2). Results from five workshops, including brachial plexus, musculoskeletal, pelvic, gastrointestinal, and head and neck anatomy, showed that students performed significantly (p ≤ 0.05) better on the post‐session quizzes compared to pre‐session quizzes in all sessions. Post‐session survey results indicated that students were satisfied with session content and facilitation, would attend future workshops, and would use session materials to study for Step 1. Based on these short‐term benefits of the sessions, we plan to continue offering monthly workshops to medical students to increase knowledge retention of key anatomical concepts and increase preparedness for clerkships and Step 1. Future studies will longitudinally follow up with students post‐Step 1 and clerkships to determine the long‐term benefits of offering these workshops.
Energetics of Oligosaccharide Adsorption on Ionic Liquid‐Clay Composites
Authors: Nethi Shravani , Hazra Rituparna , Kumar Jagannathareddy Dinesh , Roy Durba 
Published: November 2024

AbstractWell‐Tempered Metadynamics (WT‐MetaD) simulations indicate that composite materials made up of Na‐Montmorillonite (Na‐MMT) coated with ionic liquids (ILs) having hydrophilic cations serve as good adsorbents for a hexameric (1,4) linked β‐D‐glucopyranoside (BGLC). Hydrophilic IL cations are effectively coated on the negative charges lining the Na‐MMT surface while attracting simultaneously the polar oligosaccharides. In this work we have used two less conventional polyethylene glycol (PEG) based IL cations, [mim2 peg1]2+ and [mim2 peg2]2+, paired with [tf2N]− and Cl− anions. Another strongly hydrophilic ion combination, [C2OHmim][Cl], also showed great promise in effective oligosaccharide adsorption on the Na‐MMT surface. The study reveals that the topological polar surface area (TPSA), the octanol‐water partition coefficient (log PO/W), the length of the cationic side chain and the Debye screening length
of the IL are some of the most important factors affecting the adsorption of hydrophilic oligosaccharides on the clay‐IL composites. Among all the systems studied, [mim2 peg2][tf2N]2 having the highest TPSA and a long screening length emerged as the best adsorbent for the oligosaccharide on the IL‐coated clay.
Conditional Variable Screening for Ultra‐High Dimensional Longitudinal Data With Time Interactions
Authors: Bratsberg Andrea , Ghosh Abhik , Thoresen Magne 
Published: November 2024

ABSTRACTIn recent years, we have been able to gather large amounts of genomic data at a fast rate, creating situations where the number of variables greatly exceeds the number of observations. In these situations, most models that can handle a moderately high dimension will now become computationally infeasible or unstable. Hence, there is a need for a prescreening of variables to reduce the dimension efficiently and accurately to a more moderate scale. There has been much work to develop such screening procedures for independent outcomes. However, much less work has been done for high‐dimensional longitudinal data in which the observations can no longer be assumed to be independent. In addition, it is of interest to capture possible interactions between the genomic variable and time in many of these longitudinal studies. In this work, we propose a novel conditional screening procedure that ranks variables according to the likelihood value at the maximum likelihood estimates in a marginal linear mixed model, where the genomic variable and its interaction with time are included in the model. This is to our knowledge the first conditional screening approach for clustered data. We prove that this approach enjoys the sure screening property, and assess the finite sample performance of the method through simulations.
Incompletely Observed Nonparametric Factorial Designs With Repeated Measurements: A Wild Bootstrap Approach
Authors: Amro Lubna , Konietschke Frank , Pauly Markus 
Published: November 2024

ABSTRACTIn many life science experiments or medical studies, subjects are repeatedly observed and measurements are collected in factorial designs with multivariate data. The analysis of such multivariate data is typically based on multivariate analysis of variance (MANOVA) or mixed models, requiring complete data, and certain assumption on the underlying parametric distribution such as continuity or a specific covariance structure, for example, compound symmetry. However, these methods are usually not applicable when discrete data or even ordered categorical data are present. In such cases, nonparametric rank‐based methods that do not require stringent distributional assumptions are the preferred choice. However, in the multivariate case, most rank‐based approaches have only been developed for complete observations. It is the aim of this work to develop asymptotic correct procedures that are capable of handling missing values, allowing for singular covariance matrices and are applicable for ordinal or ordered categorical data. This is achieved by applying a wild bootstrap procedure in combination with quadratic form‐type test statistics. Beyond proving their asymptotic correctness, extensive simulation studies validate their applicability for small samples. Finally, two real data examples are analyzed.
Cyclic Voltammetry Study and Solar Light Assisted Photocatalytic Activity of the CeFeO3/CeO2/Fe2O3 Composite
Authors: Kanimozhi M. , Harikrishnan R. , Mani M. , Kumaresan S. , Rajasekar A. , Devi N. Saradha , Radhakrishnan Shankara G. , Sibali L. , Kaviyarasu K. 
Published: November 2024

ABSTRACTThe semiconducting nature of CeFeO3/CeO2/Fe2O3 nanocomposite has permitted the degradation of the organic toxic dye methylene blue under the irradiation of ultraviolet and visible light portions of solar radiation. Fullprof‐assisted Rietveld refinement analysis, performed using the Match software, has revealed the orthorhombic nature of CeFeO3. In addition, in the synthesized material, the cubic phase byproduct CeO2 was found due to the highly oxidizing nature of the cerium element. This occurred due to 6 min microwave irradiation because the microwave‐assisted technique offered random distribution of heating during the supply of 800‐W power for 30 s, followed by 12 cycles. Additionally, the presence of Fe2O3 was also confirmed through Match software‐assisted Rietveld refinement analysis through phase matching. During the synthesis, a certain portion of the synthesized CeFeO3 experienced overheating, leading to phase transformation from CeFeO3 into Fe2O3 and CeO2. The unit cell compositions of CeFeO3, CeO2, and Fe2O3 were found in the sample material with 35.54%, 52.43%, and 12.03%, respectively. The appearance of a fingerprint absorption region in the FTIR spectrum around 577.36 and 535.38 cm−1 further confirmed the similarity of these values (577.36 and 535.38 cm−1) to those obtained from the calculated values obtained by substituting Rietveld refined bond length parameters. The fourth step process in the thermal analysis curve (TGA) revealed the oxidation process, which led to the destruction of the CeFeO3 phase, causing the transformation of CeFeO3 into two byproducts (CeO2 and Fe2O3). This oxidation process permitted in an observable weight gain, which is observed in the thermal analysis curve (TGA). A cyclic voltammetry study (the experimentally measured current–voltage characteristic curve) revealed slightly distorted semirectangular CV curves, confirming the pseudo‐capacitive behavior of the synthesized composite.
Expression of Viral DNA Polymerase in Synthetic Recombinant Adeno‐Associated Virus Producer Cell Line Enhances Full Particle Productivity
Authors: Lin Yu‐Chieh , Kuo Han‐Jung , Lu Min , Rungkittikhun Carissa , Hu Wei‐Shou 
Published: November 2024

ABSTRACTRecombinant adeno‐associated virus (rAAV) is a widely used viral vector in gene therapy. To meet the growing clinical demand, a scalable production technology which can efficiently produce high‐quality products is required. We have developed a synthetic biology strategy to generate HEK293‐based cell lines which have integrated essential AAV and adenoviral helper genes and are capable of producing rAAV upon induction. One such cell line, GX6B, produced up to 106 capsids per cell, but only a much lower level of rAAV genomes. The low AAV genome titer limited its rAAV productivity and increased empty viral particle content. To boost AAV genome amplification, the coding sequence of the DNA polymerase complex (UL30/UL42) from helper Herpes Simplex Virus type 1 (HSV‐1) was placed under an inducible promoter control and integrated into GX6B genome at a relatively low level. The resulting clones produced significantly higher titer of viral genomes, while their capsid level was unaffected. As a result, the encapsidated rAAV2 titer and the full particle content were significantly increased. We further demonstrated that this strategy of expressing HSV‐1 DNA polymerase to increase full particle productivity could be implemented in a synthetic cell line producing another serotype rAAV8.
Enhancing Strategic Performance Through Sustainable Practices: The Nexus of Social Responsibility Practice and Competitive Advantage—Moderating Role of Business Ownership Type
Authors: Waktola Bekan Serbessa , Singh Manjit , Singh Sandeep 
Published: November 2024

ABSTRACTIntegrating sustainable business practices is crucial for long‐term strategic success in today's ever‐changing corporate environment. This research examines the relationship between social responsibility practices and competitive advantage in the banking industry, with the focus on how these activities might improve a bank's strategic performance. Furthermore, the study investigates the moderating role of business ownership type in the relationship between social responsibility and competitive advantage. This study employed a quantitative research design. The survey questionnaire was used to collect data. Data were collected from 385 customers of selected commercial banks in Ethiopia. The study used Partial Least Square Modeling (PLS‐SEM) to test relationships between variables. Social responsibility practice is measured from the perspectives of banks' philanthropic, economic, legal, and ethical activities. Bank ownership type was considered a moderating variable. The study findings show that social responsibility practices significantly influence the bank's competitive advantage. Similarly, including the moderating variable, bank ownership type, did not significantly change the relationship between social responsibility practices and competitive advantage. The results provide useful insights for business executives and practitioners who want to include sustainability into their strategy frameworks, fostering economic, social, and environmental well‐being. This study emphasizes the need to use sustainable business practices to gain a competitive edge and achieve sustainable business performance. It shows that responsible corporate behavior may result in greater strategic performance.
Endoluminal photodynamic therapy with a photoreactive stent‐based catheter system to treat malignant colorectal obstruction
Authors: Eo Seung Jin , Ryu Dae Sung , Lee Hyeonseung , Kim Ji Won , Kim Song Hee , Noh Jin Hee , Kim Yuri , Kang Seokin , Na Kun , Park Jung‐Hoon , Kim Do Hoon 
Published: November 2024

AbstractPhotodynamic therapy (PDT) using photosensitizer (PS)‐embedded silicone membrane‐covered self‐expandable metallic stents (SEMSs) can function in palliative therapeutic option for malignant gastrointestinal tract obstruction. However, stent‐related complications should be considered, and accurate delivery of light sources is technically difficult. Here, a Chlorin e6 (Ce6)‐an embedded stent‐based catheter is developed to improve its therapeutic efficacy and safety. PDT using Ce6‐embedded stent successfully induced cell death of colorectal cancer cell line. PDT‐treated liver tissues showed an increase in ablation depth in proportion to irradiation energy, and 600 J/cm2 demonstrates an even and sufficient ablation depth. Endoluminal PDT using the Ce6‐embedded stent‐based catheter was technically successful in a rat colon model without procedure‐related complications such as colonic perforation or stricture formation. The results in colonoscopy, colonography, and histological examination, along with statistical analysis, suggest that a novel PDT modality using a Ce6‐embedded stent‐based catheter was safely conducted and demonstrated apoptotic cell death at 12 h after PDT, and it gradually recovered from 2 to 4 weeks. Thus, the PDT using the Ce6‐embedded stent‐based catheter may represent a promising new approach for the treatment of malignant colorectal obstruction.
Profiles of Fatigue and Psychological Symptoms in Long‐Term Childhood, Adolescent, and Young Adult Cancer Survivors—The NOR‐CAYACS Study
Authors: Deng Wei H. , Lie Hanne C. , Ruud Ellen , Loge Jon H. , Kiserud Cecilie E. , Rueegg Corina S. 
Published: November 2024

ABSTRACTIntroductionLong‐term childhood, adolescent, and young adult cancer survivors (CAYACS) are at risk of fatigue and psychological problems. However, their interactions remain largely unexplored. Understanding how they cluster can inform treatment and person‐centered follow‐up care. We aimed to identify and describe profiles of co‐occurring fatigue and psychological symptoms and investigate their associations with health‐related quality of life (HRQOL) in CAYACS.MethodsNOR‐CAYACS (The Norwegian Childhood, Adolescents and Young Adult Cancer Survivors study) was a nationwide survey involving adult survivors of any childhood cancer (aged < 19 years at diagnosis) and selected young adult cancers (breast and colorectal cancers, non‐Hodgkin lymphoma, leukemias, and malignant melanomas, aged 19–39 years at diagnosis) identified through the Cancer Registry of Norway. We included 1893 survivors aged ≥ 18 years, ≥ 5 years since diagnosis. We performed latent profile analysis with six continuous outcomes: physical and mental fatigue, depression, anxiety, post‐traumatic stress symptoms, and fear of recurrence.ResultsWe identified an overall “Low” (64%), a “Moderate fatigue/high anxiety” (18%), a “High fatigue/moderate distress” (13%), and an overall “High” (5%) symptom burden profile. The “High” profile exhibited lowest physical‐ and mental‐HRQOL with T‐scores −9.8 (95% confidence interval [95% CI]: −12.5, −7.1) and −25.0 (95% CI: −26.7, −23.3) compared to the “Low” profile.ConclusionWe identified four profiles, two characterized by high fatigue and two near normative fatigue levels, each with different psychological symptom burden. Greater symptom burden corresponded to lower HRQOL, with high fatigue profiles showing lower physical HRQOL. These profiles help identify at‐risk individuals and allow for targeting interventions and follow‐up care to survivors' unique constellation of symptoms.