bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convictfish on the move: variation in growth and trophic niche space along a latitudinal gradient
Authors: Miranda T , Smith J A , Suthers I M , Mazumder D , Cruz D O , Schilling H T , Searle K , Vergés A 
Published: May 2019

Abstract
The range expansion of tropical fish into temperate waters is increasing markedly in response to climate change. Range-expanding fish encounter novel diets and environments, but we know little about how these conditions facilitate or hinder distribution shifts. Here, we quantified relative growth rate, morphometric condition and trophic niche of juvenile Acanthurus triostegus, a dominant range-expanding tropical surgeonfish, at four locations across 10° of latitude off eastern Australia. We related these metrics to differences in temperature and nutritional quality of dominant seaweeds and the epilithic algal matrix. Temperate food sources were richer in nitrogen than tropical diets. Stable isotope analysis (δ13 carbon and δ15 nitrogen) of fish muscle revealed a large trophic niche breadth at the highest latitude indicating a generalist foraging strategy, and more nitrogen-enriched isotopic signatures compared to tropical regions. Fish length was strongly correlated to δ13C in all regions, suggesting an ontogenetic shift in diet independent of latitude. Despite temperature differences of 4°C, fish growth and body condition were similar across tropical and temperate regions. These results suggest that more nutritious temperate diets may compensate for the effects of cooler water temperatures. Neither summer water temperatures nor dietary factors appear to limit the success of juvenile tropical vagrants as they continue to expand their range along eastern Australia.
Research on structural parameter optimization and thermal performance of twin-screw expander
Authors: Zhang Chenghu , Gao Jiahao , Fu Jie , Li Yaping , Lin Jiyou 
Published: May 2019

Abstract
This paper analyzes rotor profile and meshing law of twin-screw expander. Elementary area is calculated by meshing sequence method, and elementary volume is solved by integration. The influence of geometric characteristics such as torsion angle and internal expansion angle of male rotor on the thermal performance of twin-screw expander is studied. The results show the following: reasonably reducing internal expansion angle and positive rotor torsion angle can increase isentropic adiabatic power of twin-screw expander. Taking isentropic adiabatic efficiency as optimization goal, sequential quadratic programming algorithm is used to optimize the structural parameters of twin-screw expander, and the influence of leakage on its functional force is analyzed. Considering leakage effect, actual shaft power of twin-screw expander is 16.7 kW, the isentropic adiabatic power under ideal conditions is 21.3 kW, and the adiabatic efficiency is 78.71%.
Smooth Compactness for Spaces of Asymptotically Conical Self-Expanders of Mean Curvature Flow
Authors: Bernstein Jacob , Wang Lu 
Published: May 2019

AbstractWe show compactness in the locally smooth topology for certain natural families of asymptotically conical self-expanding solutions of mean curvature flow. Specifically, we show such compactness for the set of all 2D self-expanders of a fixed topological type and, in all dimensions, for the set of self-expanders of low entropy and for the set of mean convex self-expanders with strictly mean convex asymptotic cones. From this we deduce that the natural projection map from the space of parameterizations of asymptotically conical self-expanders to the space of parameterizations of the asymptotic cones is proper for these classes.
Designing the Child’s World: Ernö Goldfinger and the Role of the Architect, 1933–1946
Authors: McKellar Erin 
Published: May 2019

Abstract
Before Hungarian-born British architect Ernö Goldfinger became known for designing large-scale urban housing and office developments, he built a reputation designing toys, furnishings, interiors and exhibitions for and about children. Focussing on these projects, this article investigates how the architect sought to create a lasting audience for modern architecture by teaching children how to navigate the world independently. By looking at these projects, it is also possible to see how Goldfinger, and other architects, have bridged disciplinary categories by encompassing aspects of industrial, interior, urban and graphic design as part of a broad definition of architecture.
Curative thoraco-systemic therapy plus local treatment to the brain for extensive disease-small-cell lung cancer with metastasis only to the brain
Authors: Shibata Kazuhiko , Iwasa Keiichi , Takanaka Tsuyoshi , Yachi Tsuyoshi , Okazaki Akihito , Shiba Yasutaka , Kasahara Kazuo 
Published: May 2019

Abstract
We reviewed 11 cases of extensive disease (ED)-SCLC and metastasis only to the brain treated during 2011–14. All patients underwent definitive therapy similar to that for limited disease (LD), combined with local treatment for BM. We compared the survival outcomes of these patients to those of patients with LD (n = 29) or other ED (n = 38) during the same period. Three patients had progression of BM at completion of chemotherapy. Ten patients received whole-brain radiotherapy (4 prophylactic, 6 therapeutic), and remaining one elderly patient underwent stereotactic radiosurgery. Finally, 8 and 3 patients achieved a CR or PR of BM, respectively. Five remained free of progression for 21.1–73.2 months. The progression-free and overall survival outcomes of ED-SCLC with brain only metastases were comparable to those of LD and superior to those of other ED. In conclusion, ED-SCLC with metastasis limited to the brain could be treated with curative intent.
Alp7-Mto1 and Alp14 synergize to promote interphase microtubule regrowth from the nuclear envelope
Authors: Liu Wenyue , Zheng Fan , Wang Yucai , Fu Chuanhai 
Published: May 2019

AbstractMicrotubules grow not only from the centrosome but also from various noncentrosomal microtubule-organizing centers (MTOCs), including the nuclear envelope (NE) and pre-existing microtubules. The evolutionarily conserved proteins Mto1/CDK5RAP2 and Alp14/TOG/XMAP215 have been shown to be involved in promoting microtubule nucleation. However, it has remained elusive as to how the microtubule nucleation promoting factors are specified to various noncentrosomal MTOCs, particularly the NE, and how these proteins coordinate to organize microtubule assembly. Here, we demonstrate that in the fission yeast Schizosaccharomyces pombe, efficient interphase microtubule growth from the NE requires Alp7/TACC, Alp14/TOG/XMAP215, and Mto1/CDK5RAP2. The absence of Alp7, Alp14, or Mto1 compromises microtubule regrowth on the NE in cells undergoing microtubule repolymerization. We further demonstrate that Alp7 and Mto1 interdependently localize to the NE in cells without microtubules and that Alp14 localizes to the NE in an Alp7 and Mto1-dependent manner. Tethering Mto1 to the NE in cells lacking Alp7 partially restores microtubule number and the efficiency of microtubule generation from the NE. Hence, our study delineates that Alp7, Alp14, and Mto1 work in concert to regulate interphase microtubule regrowth on the NE.
Hydrologic Modifications Challenge Bottomland Hardwood Forest Management
Authors: King Sammy L , Keim Richard F 
Published: May 2019

AbstractBottomland hardwoods are floodplain forests along rivers and streams throughout the southeastern United States. The interrelations among hydrology, soils, geomorphic landforms, and tree species composition are the foundation of forest management in bottomland hardwoods, and historically their correspondence has allowed for somewhat predictable forest responses based upon the hydrogeomorphic setting. However, extensive hydrologic and geomorphic modifications in floodplains have disrupted these interrelations and, on many sites, have created novel disturbance regimes resulting in unpredictable forest responses. Reduced or altered timing of surface flooding and groundwater declines are common in the region and have favored increases in stem densities, particularly of species less tolerant of flooding and more tolerant of shade. In these highly modified systems, more process-level understanding of floodplain hydrology, soil moisture dynamics, interspecific tree competition, and regeneration is needed to develop more effective management prescriptions and for forestry to be represented in integrated water-resource management decisions.
Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription
Authors: Velichko Artem K , Petrova Nadezhda V , Luzhin Artem V , Strelkova Olga S , Ovsyannikova Natalia , Kireev Igor I , Petrova Natalia V , Razin Sergey V , Kantidze Omar L 
Published: May 2019

Abstract
The contribution of nucleoli to the cellular stress response has been discussed for over a decade. Stress-induced inhibition of RNA polymerase I-dependent transcription is hypothesized as a possible effector program in such a response. In this study, we report a new mechanism by which ribosomal DNA transcription can be inhibited in response to cellular stress. Specifically, we demonstrate that mild hypoosmotic stress induces stabilization of R loops in ribosomal genes and thus provokes the nucleoli-specific DNA damage response, which is governed by the ATM- and Rad3-related (ATR) kinase. Activation of ATR in nucleoli strongly depends on Treacle, which is needed for efficient recruitment/retention of TopBP1 in nucleoli. Subsequent ATR-mediated activation of ATM results in repression of nucleolar transcription.
Parkinson Disease-Related Pattern of Glucose Metabolism Associated With the Potential for Motor Improvement After Deep Brain Stimulation
Authors: Lee Eun Jung , Oh Jungsu S , Moon Hyojeong , Kim Min-Ju , Kim Mi Sun , Chung Sun Ju , Kim Jae Seung , Jeon Sang Ryong 
Published: May 2019

Abstract

BACKGROUND
Motor dysfunctions in Parkinson disease (PD) patients are not completely normalized by deep brain stimulation (DBS), and there is an obvious difference in the degree of symptom improvement after DBS for each patient.

OBJECTIVE
To test our hypothesis that each patient has their own restoration capacity for motor improvement after DBS, and to investigate whether regional cerebral glucose metabolism in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans is associated with the capacity for off-medication motor improvement (MIoff) after DBS.

METHODS
The MIoff (%) was calculated using the Unified Parkinson's Disease Rating Scale part III in 27 PD patients undergoing DBS in the globus pallidus interna. The standardized uptake value ratios (SUVRs) on FDG-PET were quantitatively measured, and the areas where the SUVR correlated with the MIoff (%) were identified. Also, the areas where the SUVR was significantly different between the 2 MIoff groups (≥60% vs <60%) were determined.

RESULTS
Ten patients achieved MIoff > 60% at 12 mo after DBS. In general, the MIoff (%) was positively correlated with preoperative SUVR in the temporo-parieto-occipital lobes, while it was inversely correlated with the metabolism in the primary motor cortex. The patients in the MIoff < 60% group showed a significant decrease in SUVR in the parieto-occipital lobes, while parieto-occipital metabolism in those with MIoff ≥ 60% was relatively preserved (Mann-Whitney U test, P = .03).

CONCLUSION
Our findings suggest that the parieto-occipital lobes may be implicated more generally in the prognosis of motor improvement after DBS in advanced PD than other regions.
Effects of hesperidin consumption on cardiovascular risk biomarkers: a systematic review of animal studies and human randomized clinical trials
Authors: Pla-Pagà L , Companys J , Calderón-Pérez L , Llauradó E , Solà R , Valls R M , Pedret A 
Published: May 2019

Abstract

Context
The cardioprotective effects of the flavonoid hesperidin, which is present in citrus products, are controversial and unclear. This systematic review was conducted in accordance with the PRISMA 2015 guidelines.

Objective
To evaluate the current evidence from animal and human clinical studies and thus determine whether the consumption of hesperidin exerts beneficial effects on cardiovascular risk factors.

Data sources
PICOS (Population, Intervention, Comparison, Outcome, and Study Design) criteria defined the research question. Searches of the PubMed and Cochrane Plus databases were conducted and studies that met the inclusion criteria and were published in English in the last 15 years were included.

Data extraction
The first author, year of publication, study design, characteristics of animals and humans, intervention groups, dose of hesperidin, route of administration, duration of the intervention, cardiovascular risk biomarkers assessed, and results observed were extracted from the included articles.

Results
A total of 12 animal studies and 11 randomized clinical trials met the inclusion criteria. In the animal studies, the glucose, total and LDL cholesterol, and triglyceride levels decreased with chronic flavonoid consumption. In the human studies, endothelial function improved with flavonoid consumption, whereas no conclusive results were observed for the other biomarkers.

Conclusions
Animal studies have revealed that hesperidin and hesperetin consumption reduces glucose levels and various lipid profile parameters. However, a definitive conclusion cannot be drawn from the existing human clinical trials. Further research is needed to confirm whether the findings observed in animal models can also be observed in humans.

Systematic Review Registration
Prospero registration number CRD42018088942.
Differential Recovery in Early- and Late-Onset Delayed Facial Palsy Following Vestibular Schwannoma Resection
Authors: Chang Stephano , Makarenko Serge , Despot Ivan , Dong Charles , Westerberg Brian D , Akagami Ryojo 
Published: May 2019

AbstractBACKGROUNDDelayed facial palsy (DFP) after resection of vestibular schwannomas (VS) is worsening of facial nerve function after an initially normal postoperative result.OBJECTIVETo characterize different types of DFP, compare recovery rates, and review of series of outcomes in patients following resection of VS.METHODSBetween 2001 and 2017, 434 patients (51% female) with VS underwent resection. We categorized the patients who developed facial palsy into groups based on timing of onset after surgery, immediate facial palsy (IFP), early-onset DFP (within 48 h), and late-onset DFP (after 48 h). Introduction of facial nerve motor-evoked potentials (fMEP) in 2002 and a change of practice utilizing perioperative minocycline in 2005 allowed for historical analysis of these interventions.RESULTSMean age of study cohort was 49.1 yr (range 13-81 yr), with 19.8% developing facial palsy. The late-onset DFP group demonstrated a significantly faster recovery than the early-onset DFP group (2.8 ± 0.5 vs 47 ± 8 wk,P < .0001), had prolonged latency to palsy onset after initiating perioperative minocycline (7.3 vs 12.5 d,P = .001), and had a nonsignificant trend towards faster recovery from facial palsy with use of minocycline (2.6 vs 3.4 wk,P = .11).CONCLUSIONGiven the timings, it is likely axonal degeneration is responsible for early-onset DFP, while demyelination and remyelination lead to faster facial nerve recovery in late-onset DFP. Reported anti-apoptotic properties of minocycline could account for the further delay in onset of DFP, and possibly reduce the rate and duration of DFP in the surgical cohort.
Tofacitinib modulates the VZV-specific CD4+ T cell immune response in vitro in lymphocytes of patients with rheumatoid arthritis
Authors: Almanzar Giovanni , Kienle Felix , Schmalzing Marc , Maas Anna , Tony Hans-Peter , Prelog Martina 
Published: May 2019

AbstractObjectiveRA is a chronic inflammatory disease characterized by lymphocyte infiltration and release of inflammatory cytokines. Previous studies have shown that treatment with Janus kinase inhibitors, such as tofacitinib, increased the incidence rate of herpes zoster compared with conventional DMARDs. Therefore, this study aimed to investigate the effect of tofacitinib on the varicella-zoster-virus (VZV)-specific T cell immune response.MethodsThe effect of tofacitinib on the VZV-specific T cell immune response was determined by evaluating the IFNγ production, the proliferative capacity, the VZV-induced differentiation into effector and memory T cells, the expression of activation marker CD69 and helper T cell type 1 (Th1)-characteristic chemokine receptors, such as CXCR3 and CCR5, as well as cytotoxic activity (perforin and granzyme B expression) of CD4+ T cells of patients with RA compared with healthy donors upon stimulation with VZV antigen in vitro.ResultsTofacitinib significantly reduced the IFNγ production, proliferation, activation, and CXCR3 expression of VZV-specific CD4+ T cells in a dose-dependent manner in short- and long-term lymphocyte culture. No effect on the distribution of naive, effectors or memory, or on the expression of perforin or granzyme B by VZV-specific CD4+ T cells was observed.ConclusionThis study showed that tofacitinib significantly modulated the Th1 response to VZV. The poor VZV-specific cellular immune response in patients with RA may be considered in recommendations regarding appropriate vaccination strategies for enhancing the VZV-specific Th1 response.
Effects of increasing dietary zinc on growth performance and carcass characteristics of pigs raised under commercial conditions1,2
Authors: Cemin Henrique S , Woodworth Jason C , Tokach Mike D , Dritz Steve S , DeRouchey Joel M , Goodband Robert D , Usry James L 
Published: May 2019

Abstract
A total of 2,430 pigs (PIC 337 × 1050; Hendersonville, TN; initially 30.1 kg) were used in a 113-d growth trial to determine the effects of increasing dietary Zn on growth performance and carcass characteristics of finishing pigs raised under commercial conditions. Pens of pigs were assigned to be fed one of five dietary treatments in a randomized complete block design. Treatments consisted of 50, 87.5, 125, 162.5, or 200 mg/kg added Zn from Zn hydroxychloride (IntelliBond Z, Micronutrients, Indianapolis, IN). Two identical barns were used for a total of 18 pens per treatment with 27 pigs per pen. Experimental diets were fed in five phases and contained a vitamin-trace mineral premix without added Zn. Pens of pigs were weighed approximately every 2 wk to calculate average daily gain (ADG), average daily feed intake (ADFI), and gain-to-feed ratio (G:F). At the end of the experimental period, pigs were tattooed with a pen identification number and transported to a packing plant to measure hot carcass weight (HCW), backfat, loin depth, and calculated lean percentage. Data were analyzed block nested within barn as a random effect and pen as the experimental unit. From days 0 to 42, pigs fed diets with increasing added Zn had lower (linear, P = 0.043) ADFI and a tendency (P = 0.092) for lower ADG. From days 42 to 113, increasing added Zn resulted in a quadratic response (P = 0.042) for ADFI and a tendency (linear, P = 0.056) for improved G:F. Overall (days 0 to 113), there were tendencies for quadratic responses for ADFI (P = 0.073) and G:F (P = 0.059), with the greatest G:F observed when 125 mg/kg of Zn was fed. Increasing added Zn resulted in a linear increase (P &lt; 0.001) in daily Zn intake. There were no differences (P &gt; 0.10) in overall ADG, final body weight, HCW, backfat, loin depth, lean percentage, mortality, and removal rate. In conclusion, there were no improvements in ADG when feeding beyond 50 mg/kg added Zn; however, providing 125 mg/kg added Zn resulted in the greatest G:F.
Effects of zinc source and level on growth performance and carcass characteristics of finishing pigs1,2
Authors: Cemin Henrique S , Carpenter Corey B , Woodworth Jason C , Tokach Mike D , Dritz Steve S , DeRouchey Joel M , Goodband Robert D , Usry James L 
Published: May 2019

Abstract
An experiment was conducted to determine the effects of added Zn source and level on growth performance and carcass characteristics of finishing pigs. A total of 1,980 pigs divided into 2 groups [group 1: 1,008 pigs, TR4 × (Fast Large White × PIC L02) and group 2: 972 pigs, PIC 337 × 1,050], initially 33.3 kg, were used in a 103- or 114-d growth trial in groups 1 and 2, respectively. Treatments were arranged in a 2 × 3 factorial with 2 sources of added Zn, Zn hydroxychloride (ZnHyd; IntelliBond Z, Micronutrients, Indianapolis, IN) or Zn sulfate (ZnSO4), and 3 levels of added Zn (50, 100, or 150 mg/kg). Diets contained a vitamin-trace mineral premix without added Zn and provided 76 and 162 mg/kg Fe and Cu, respectively. All diets contained 750 FTU/kg phytase. There was a total of 14 replicates per treatment. Pens of pigs were weighed approximately every 2 wk to determine average daily gain (ADG), average daily feed intake, and gain-to-feed ratio. At the end of the experiment, pigs were transported to a packing plant to determine hot carcass weight (HCW), backfat depth, loin depth, and lean percentage. Overall, there was no evidence (P &gt; 0.10) for interactive effects of added Zn source and level for growth performance and carcass characteristics. Pigs fed diets with increasing added Zn had a tendency (P = 0.093) for a quadratic response in ADG, with the greatest ADG observed at 100 mg/kg added Zn. There was a linear improvement (P = 0.010) in carcass yield and a quadratic response (P = 0.045) in HCW, with pigs fed 100 mg/kg added Zn having the highest HCW. Pigs fed diets with ZnHyd had improved (P = 0.017) carcass yield and a tendency (P = 0.058) for greater HCW compared with pigs fed ZnSO4. In summary, under the commercial conditions of the study and with diets containing 750 FTU/kg phytase, there were relatively small improvements in ADG of growing-finishing pigs fed added Zn beyond 50 mg/kg. Providing higher levels of added Zn improved carcass characteristics. Zinc source did not influence growth performance, but ZnHyd improved carcass characteristics compared with ZnSO4.
Predicting Human Infection Risk: Do Rodent Host Resistance Models Add Value?
Authors: Wu Kai Connie , Zhong Yu , Maher Jonathan 
Published: May 2019

AbstractUse of genetically engineered rodents is often considered a valuable exercise to assess potential safety concerns associated with the inhibition of a target pathway. When there are potential immunomodulatory risks associated with the target, these genetically modified animals are often challenged with various pathogens in an acute setting to determine the risk to humans. However, the applicability of the results from infection models is seldom assessed when significant retrospective human data become available. Thus, the purpose of the current review is to compare the outcomes of infectious pathogen challenge in mice with genetic deficiencies in TNF-α, IL17, IL23, or Janus kinase pathways with infectious outcomes caused by inhibitors of these pathways in humans. In general, mouse infection challenge models had modest utility for hazard identification and were generally only able to predict overall trends in infection risk. These models did not demonstrate significant value in evaluating specific types of pathogens that are either prevalent (ie rhinoviruses) or of significant concern (ie herpes zoster). Similarly, outcomes in mouse models tended to overestimate the severity of infection risk in human patients. Thus, there is an emerging need for more human-relevant models that have better predictive value. Large meta-analyses of multiple clinical trials or post-marketing evaluations remains the gold-standard for characterizing the true infection risk to patients.