bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the new World Health Organization’s dengue classification for predicting severity of illness and level of healthcare required
Authors: Ajlan Balgees A. , Alafif Maram M. , Alawi Maha M. , Akbar Naeema A. , Aldigs Eman K. , Madani Tariq A. 
Published: January 2019

AbstractThe objective of this observational study was to assess the validity of the new dengue classification proposed by the World Health Organization (WHO) in 2009 and to develop pragmatic guidelines for case triage and management. This retrospective study involved 357 laboratory-confirmed cases of dengue infection diagnosed at King Abdulaziz University Hospital, Jeddah, Saudi Arabia over a 4-year period from 2014 to 2017. The sensitivity of the new classification for identifying severe cases was limited (65.0%) but higher than the old one (30 0%). It had a higher sensitivity for identifying patients who needed advanced healthcare compared to the old one (72.0% versus 32.0%, respectively). We propose adding decompensation of chronic diseases and thrombocytopenia-related bleeding to the category of severe dengue in the new classification. This modification improves sensitivity from 72.0% to 97.5% for identifying patients who need advanced healthcare without altering specificity (96.7%). It also improves sensitivity in predicting severe outcomes from 32% to 88.0%. In conclusion, the new classification had a low sensitivity for identifying patients needing advanced care and for predicting morbidity and mortality. We propose to include decompensation of chronic diseases and thrombocytopenia-related bleeding to the category of severe dengue in the new classification to improve the sensitivity of predicting cases requiring advanced care.Author summaryDengue fever, the most prevalent arthropod-borne viral disease in human, has been conventionally classified into four main categories: non-classical, classical, dengue hemorrhagic fever, and dengue shock syndrome. Several studies reported lack of correlation between the categories of the conventional classification and the disease severity. As a consequence, the World Health organization proposed in 2008 a new classification that divides dengue into two categories: non-severe and severe dengue; the non-severe dengue is further divided into two categories: dengue with warning signs and dengue without warning signs. In this retrospective study we reviewed 357 cases of dengue diagnosed in our institution over a 4-year period to assess the validity of the new dengue classification in order to develop pragmatic guidelines for case triage and management in the Emergency Departments. We found that the sensitivity of the new classification for identifying severe cases was limited even though it had a higher sensitivity for identifying patients who needed advanced healthcare compared to the old one. We propose adding decompensation of chronic diseases and low platelets-related bleeding to the category of severe dengue in the new classification. This modification dramatically improves the sensitivity for identifying patients who need advanced healthcare and the sensitivity to predict severe outcomes.
Electrophysiological measures of sleep pressure during wakefulness in the course of isolation at the Concordia Antarctica station and physical activity as a countermeasure
Authors: Petit Gaetan , Abeln Vera , Summerer Leopold , Schneider Stefan , Huber Reto 
Published: January 2019

AbstractConcordia station in Antarctica is one of the most remote human outpost on Earth. Because of its geographical location, a winterover at Concordia shares a lot of stressors with a space mission. Following a recent study on the markers of sleep pressure during wakefulness on board of the International Space Station, we were investigating if long term isolation in a space analogue station shows similar effects on sleep pressure. Unlike in space, markers of sleep pressure did not increase during isolation’s constant darkness period in Antarctica. When measures of sleep pressure were high in the evening, psychological strain was increased, emphasising the importance of keeping sleep pressure under physiological levels during the mission. As a first indication for a countermeasure, we showed that one hour of bicycle exercise during lunch time could decrease sleep pressure. All these observations need to be further studied in a more controlled environment.
Temperature dependence of allelopathy duality and its influence on boreal forest succession-A case analysis of Picea schrenkiana
Authors: Ruan Xiao , Yang Li , Yu Min-fen , Li Zhao-hui , Zhao Ying-xian , Pan Cun-de , Jiang De-an , Wang Qiang 
Published: January 2019

AbstractGlobal warming in conjunction with various biotic or abiotic interferences has been jeopardizing the ecosystem of boreal forests. By integrating field inspection with experimental simulation, this work comprehensively investigated the allelopathic effects of a key allelochemical 3,4-dihydroxyacetophenone (DHAP) in the exudates of P. schrenkiana needles on its seed and seedling growth, endogenous hormone metabolism and antioxidant enzyme activity, identified the existence of DHAP allelopathy duality at a certain temperature with an inflection concentration point (e.g. about 0.25 mM at dark/light temperature of 4/12 °C) as the boundary between promotional and inhibitory effect, and verified that the inflection point of DHAP concentration would inevitably shift to a lower level as temperature increased. Consequently, this paper gives a scientific explanation into the intrinsic mechanism of P. schrenkiana degradation due to allelopathy, but also presents a new approach to explore the relationship between forest evolution and global warming.HighlightA quantitative description on the duality of 3, 4-dihydroxyacetophenone (DHAP) as a promoter or an inhibitor to affect the seed germination, seedling growth and root development of P. schrenkiana, as well as the antioxidant enzyme activities and hormone contents.The new findings of DHAP inflection concentration as boundary to divide the promotional and inhibitory effect of allelopathy which would decrease as environment temperatures rise.An explanation into the intrinsic mechanism of P. schrenkiana degradation due to allelopathy, and a new approach to explore the relationship between forest evolution and global warming.
Unrestrained ESCRT-III drives chromosome fragmentation and micronuclear catastrophe
Authors: Vietri Marina , Schultz Sebastian W. , Bellanger Aurélie , Jones Carl M. , Raiborg Camilla , Skarpen Ellen , Pedurupillay Christeen Ramane J. , Kip Eline , Timmer Romy , Jain Ashish , Collas Philippe , Knorr Roland L. , Grellscheid Sushma N. , Kusumaatmaja Halim , Brech Andreas , Micci Francesca , Stenmark Harald , Campsteijn Coen 
Published: January 2019

AbstractThe ESCRT-III membrane fission machinery1,2 restores nuclear envelope integrity during mitotic exit3,4 and interphase5,6. Whereas primary nuclei resealing takes minutes, micronuclear envelope ruptures appear irreversible and result in catastrophic collapse associated with chromosome fragmentation and rearrangements (chromothripsis), thought to be a major driving force in cancer development7-10. Despite its importance11-13, the mechanistic underpinnings of nuclear envelope sealing in primary nuclei and the defects observed in micronuclei remain largely unknown. Here we show that CHMP7, the nucleator of ESCRT-III filaments at the nuclear envelope3,14, and the inner nuclear membrane protein LEMD215 act as a compartmentalization sensor detecting the loss of nuclear integrity. In cells with intact nuclear envelope, CHMP7 is actively excluded from the nucleus to preclude its binding to LEMD2. Nuclear influx of CHMP7 results in stable association with LEMD2 at the inner nuclear membrane that licenses local polymerization of ESCRT-III. Tight control of nuclear CHMP7 levels is critical, as induction of nuclear CHMP7 mutants is sufficient to induce unrestrained growth of ESCRT-III foci at the nuclear envelope, causing dramatic membrane deformation, local DNA torsional stress, single-stranded DNA formation and fragmentation of the underlying chromosomes. At micronuclei, membrane rupture is not associated with repair despite timely recruitment of ESCRT-III. Instead, micronuclei inherently lack the capacity to restrict accumulation of CHMP7 and LEMD2. This drives unrestrained ESCRT-III recruitment, membrane deformation and DNA defects that strikingly resemble those at primary nuclei upon induction of nuclear CHMP7 mutants. Preventing ESCRT-III recruitment suppresses membrane deformation and DNA damage, without restoring nucleocytoplasmic compartmentalization. We propose that the ESCRT-III nuclear integrity surveillance machinery is a double-edged sword, as its exquisite sensitivity ensures rapid repair at primary nuclei while causing unrestrained polymerization at micronuclei, with catastrophic consequences for genome stability16-18.
Comparison between diffusion MRI tractography and histological tract-tracing of cortico-cortical structural connectivity in the ferret brain
Authors: Delettre C. , Messé A. , Dell L-A. , Foubet O. , Heuer K. , Larrat B. , Meriaux S. , Mangin J-F. , Reillo I. , de Juan Romero C. , Borrell V. , Toro R. , Hilgetag C. C. 
Published: January 2019

AbstractThe anatomical wiring of the brain is a central focus in network neuroscience. Diffusion MRI tractography offers the unique opportunity to investigate the brain fiber architecture in vivo and non invasively. However, its reliability is still highly debated. Here, we explored the ability of diffusion MRI tractography to match invasive anatomical tract-tracing connectivity data of the ferret brain. We also investigated the influence of several state-of-the-art tractography algorithms on this match to ground truth connectivity data. Tract-tracing connectivity data were obtained from retrograde tracer injections into the occipital, parietal and temporal cortices of adult ferrets. We found that the relative densities of projections identified from the anatomical experiments were highly correlated with the estimates from all the studied diffusion tractography algorithms (Spearman’s rho ranging from 0.67 to 0.91), while only small, non-significant variations appeared across the tractography algorithms. These results are comparable to findings reported in mouse and monkey, increasing the confidence in diffusion MRI tractography results. Moreover, our results provide insights into the variations of sensitivity and specificity of the tractography algorithms and hence, into the influence of choosing one algorithm over another.
Photoactivation of olfactory sensory neurons does not affect action potential conduction in individual trigeminal sensory axons innervating the rodent nasal cavity
Authors: Maurer Margot , Papotto Nunzia , Sertel-Nakajima Julika , Schueler Markus , Möhrlen Frank , Messlinger Karl , Col Roberto De , Frings Stephan , Carr Richard W 
Published: January 2019

AbstractOlfactory and trigeminal chemosensory systems reside in parallel within the mammalian nose. Psychophysical studies in people indicate that these two systems interact at a perceptual level. Trigeminal sensations of pungency mask odour perception, while olfactory stimuli can influence trigeminal signal processing tasks such as odour localization. While imaging studies indicate overlap in limbic and cortical somatosensory areas activated by nasal trigeminal and olfactory stimuli, there is also potential cross-talk at the level of the olfactory epithelium, the olfactory bulb and trigeminal brainstem. Here we focused on potential interactions between olfactory and trigeminal signaling in the nasal cavity. We first used a forced choice paradigm to ascertain whether trigeminal and olfactory stimuli could influence behavior in mice. Mice avoided water sources associated with volatile TRPV1 and TRPA1 irritants, however, this aversion was mitigated when combined with a pure odorant (rose fragrance, phenylethyl alcohol, PEA). To determine whether olfactory-trigeminal interactions within the nose could potentially account for this behavioral effect we recorded from single trigeminal sensory axons innervating the nasal epithelium using an isolated in vitro preparation. To circumvent non-specific effects of chemical stimuli, optical stimulation was used to excite olfactory sensory neurons in a mouse line expressing channel-rhodopsin under the olfactory marker protein. During photoactivation of olfactory sensory neurons there was no modulation of action potential conduction in individual trigeminal axons. Similarly, no evidence was found for trigeminal axon collateral branching that might serve as a conduit for cross-talk between the olfactory epithelium and olfactory dura mater. Using direct assessment of trigeminal signals emanating from the mouse nasal cavity we see no evidence for paracrine nor axon reflex mediated cross-talk between olfactory and trigeminal sensory systems in the nasal cavity.
A strategic analysis of tea leaves supply chain before manufacturing – a case in Assam
Authors: Paul Tripti , Mondal Sandeep 
Published: January 2019

Purpose
There exists insufficient literature on classification and taxonomy of tea leaves supply chain (TLSC), so the purpose of this paper is to study the existing TLSCs and classify them accordingly. Apart from this, the paper also focuses on identification of key decisions issues in the supply chains (SC) and developing a TLSC decision framework for the state of Assam in India.

Design/methodology/approach
The paper is based on a two-year detailed study on TLSC in Assam which encompasses 22 Tea Estates, 41 Small Tea Gardens (STGs) and a Research Institute (Tocklai Tea Research Institute). Secondary data were collected from relevant websites of various government organizations of India, company’s websites, annual reports, official statements from the companies, tea market reports, annual reports of the Indian Tea Association, the Tea Board of India, Tea Research Institute and published reports, etc.

Findings
The “point of origin” of TLSC is a tea garden, “point of consumption” is considered as a tea factory and green tea leaves (GTLs) forms the basic raw material. This SC includes mainly three players: Tea leaves growers, manufacturers of made tea and tea leaves agents. This study identifies the three types of TLSCs existing in Assam: TLSC1, TLSC2 and TLSC3. Among them, only TLSC1 is both responsive as well as an efficient chain, while the rest are only responsive chains. Later two SCs can be made efficient with the proposed TLSC4.

Research limitations/implications
There is an insufficient literature on classification and taxonomy of TLSC, therefore the study (considerably the classification and taxonomy of TLSC) was developed from the primary data which were collected from the 22 Tea Estates and 41 STGs of four districts of Assam, because of limited time (two years). The study should have involved more tea estates and small tea gardens for better classification and taxonomy.

Practical implications
The proposed model suggests that small tea growers may create a co-operative whereby smaller tea gardens (STGs) (members of the co-operative) unite to act as a single large garden, set up their own co-operative factory and recruit permanent tea plucking laborers. This up-gradation of TLSC2 and TLSC3 to TLSC4 may enable a group of STGs to work in a manner similar to a Tea Estate.

Originality/value
To the best of authors’ knowledge this is one of the first studies to classify the TLSC in Assam.
Impediments affecting the curbing of illicit financial flows of organised crime in developing economies
Authors: Sotande Emmanuel 
Published: January 2019

Purpose
The purpose of this paper is to examine the treats hindering war against illicit financial flows of organised crime in developing economies and Nigeria in particular. The examination shows that the impediments facing the fight against money laundering and organised crime financial flows vary from one country to another. It may be lesser in developed economies where most instruments, treaties and best practice recommendations to curb serious crime originated from. However, the impediments against the proceeds of organised crime in developing economies are overwhelming.

Design/methodology/approach
The research methodology adopted was qualitative analysis. This was applied through the use and analysis of documents and expert interviews.

Findings
The impediments jeopardising the success against organised crime and other related serious crime financial flows in developing economies are devastating. Consequently, the study offered some policy implications to help mitigate these impediments in developing countries. The dynamics and the phenomena of organised crime business model are operated with ingenious strategies within the global states. Therefore, staying in control of the menace and the threats originated from the organised criminal activities would require periodic review of the global initiatives, standards and strategies deployed by the standard setters to combat organised crime and its financial flows in developing and evolving economies. Additionally, the implementing countries should be carried along and allow to make inputs when such initiatives and standards are being developed.

Social implications
In Nigeria, there is a clear evidence of “collateral damage” in terms of social justice as result of financial exclusion of many bankable adults of the country that do not possess unique identities for account opening documentation and customer due diligence of the Financial Action Task Force recommendation 10.

Originality/value
There have been quite a number of studies on organised crime and still fewer have recognised the need to explore the success or failure of combating the proceeds of crime in developing economies. This study provides answer to these gaps by screening associated risks of fighting the proceeds of organised crime in developing countries and Nigeria in particular.
A Queensland research support network in emergency healthcare
Authors: Sweeny Amy , van den Berg Lisa , Hocking Julia , Renaud Julia , Young Sharleen , Henshaw Richard , Foster Kelly , Howell Tegwen 
Published: January 2019

Purpose
The purpose of this paper is to describe the structure and impact of a Queensland Research Support Network (RSN) in emergency medicine (EM).

Design/methodology/approach
This paper presents a descriptive summary of EM networks, network evaluations and the structure and development of the Emergency Medicine Foundation’s (EMF) RSN in Queensland, including an observational pre- and post-study of research metrics.

Findings
In two years, the RSN supported 33 Queensland emergency departments (EDs), of which 14 developed research strategies. There was an increase in research active clinicians, from 23 in 2015 to 181 in 2017. Collaborator engagement increased from 9 in 2015 to 276 in 2017 as did the number of research presentations, from 6 in 2015 to 61 in 2017. EMF experienced a growth in new researchers, with new investigators submitting approximately 60 per cent of grant applications in 2016 and 2017. EMF also received new applications from a further three HHS (taking EMF-funded research activity from 8 to 11 HHS).

Research limitations/implications
This paper describes changes in KPIs and research metrics, which the authors attribute to the establishment of the RSN. However, it is possible that attribution bias plays a role in the KPI improvements.

Social implications
This network has actively boosted and expanded EM research capacity and capability in Queensland. It provides services, in the form of on-the-ground managers, to develop novice clinician-researchers, new projects and engage entire EDs. This model may be replicated nationwide but requires funding commitment.

Originality/value
The RSN improves front-line clinician research capacity and capability and increases research activity and collaborations with clear community outcomes. Collaborations were extended to community, primary health networks, non-government organisations, national and international researchers and academic institutions. Evaluating and measuring a network’s benefits are difficult, but it is likely that evaluations will help networks obtain funding.
Dynamic relationship between embodied and operational impacts of buildings
Authors: Ajayi Saheed O. , Oyedele Lukumon O. , Dauda Jamiu A. 
Published: January 2019

Purpose
Buildings and their construction activities consume a significant proportion of mineral resources excavated from nature and contribute a large percentage of CO2 in the atmosphere. As a way of improving the sustainability of building construction and operation, various sustainable design appraisal standards have been developed across nations. Albeit criticism of the appraisal standards, evidence shows that increasing sustainability of the built environment has been engendered by such appraisal tools as Building Research Establishment Environmental Assessment Method (BREEAM), Code for Sustainable Homes (CfSH), Leadership in Energy and Environmental Design and Comprehensive Assessment System for Built Environment Efficacy, among others. The purpose of this paper is to evaluate the effectiveness of the appraisal standards in engendering whole lifecycle environmental sustainability of the built environment.

Design/methodology/approach
In order to evaluate the adequacy of sustainability scores assigned to various lifecycle stages of buildings in the appraisal standards, four case studies of a block of classroom were modelled. Using Revit as a modelling platform, stage by stage lifecycle environmental impacts of the building were simulated through Green Building Studio and ATHENA Impact estimator. The resulting environmental impacts were then compared against the assessment score associated with each stage of building lifecycle in BREAAM and CfSH.

Findings
Results show that albeit the consensus that the appraisal standards engender sustainability practices in the AEC industry, total scores assigned to impacts at each stage of building lifecycle is disproportionate to the simulated whole-life environmental impacts associated with the stages in some instances.

Originality/value
As the study reveals both strengths and weaknesses in the existing sustainability appraisal standards, measures through which they can be tailored to resource efficiency and lifecycle environmental sustainability of the built environment are suggested.