bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doulas in the Operating Room: An Innovative Approach to Supporting Skin‐to‐Skin Care During Cesarean Birth
Authors: Lanning Rhonda K. , Oermann Marilyn H. , Waldrop Julee , Brown Laura G. , Thompson Julie A. 
Published: December 2018

IntroductionSkin‐to‐skin care (SSC) immediately after birth is recommended for all women and their newborns. Barriers to SSC after cesarean birth lead to delays in initiation of this practice. The purpose of this quality improvement project was to implement an innovative approach with volunteer doulas to support initiation of SSC after cesarean for all clients.ProcessVolunteer doulas in a well‐established hospital‐based program within an academic health center were trained to provide care during scheduled cesarean births in the operating and recovery rooms. Data on rate and time of SSC and client and nurse satisfaction were collected for a 12‐week period.OutcomesSixty‐six women received doula‐supported care in the operating room. All medically stable woman‐newborn couplets with complete data (N = 58) initiated SSC in the operating room and were included in the data analysis. Forty‐eight women completed a feedback survey after birth. Scores indicated that clients agreed or strongly agreed that the doula was an important part of the birth experience. Feedback from labor and delivery nurses indicated highly positive attitudes about the importance of SSC and the presence of volunteer doulas. All nurses surveyed who had participated in doula care (n = 20) agreed or strongly agreed that they were satisfied with the doulas and that the doulas were prepared for this role.DiscussionThis project demonstrates that volunteer doulas can be prepared to provide supportive care to clients during and immediately after cesarean birth. Doulas can play an integral role in supporting the initiation of SSC after cesarean birth and are perceived as an important member of the maternity health care team by clients and nurses.
30 years after: CNS actions of prolactin: Sources, mechanisms and physiological significance
Authors: Bridges Robert S. , Grattan David R. 
Published: December 2018

Our understanding of the neural actions of prolactin (PRL) and its biochemical basis has expanded greatly over the past three decades. During this time, major progress has been made, including clarification of how PRL accesses the brain, identification of the PRL receptor and the sites where it is expressed within the brain, determination of the neurochemical mechanism of action of PRL and its effect on genomic expression in neurones, identification of the neural sites where PRL acts to stimulate maternal behaviour and related affective states, and exploration of how life experiences impact neural PRL receptor activity and actions. The next 30 years promise to reveal a myriad of basic and clinical findings regarding new roles for PRL and a greater indepth understanding of how and where PRL affects physiological and behavioural processes.
Effects of dietary ramie powder at various levels on growth performance, antioxidative capacity and fatty acid profile of finishing pigs
Authors: Li Yinghui , Liu Yingying , Li Fengna , Sun Ao , Lin Qian , Huang Xingguo , Yin Yulong 
Published: December 2018

AbstractThis study was conducted to evaluate the effects of ramie (Boehmeria nivea, previously known as a fibre crop and also called “China grass”) included in diets on growth performance, antioxidative capacity and muscular fatty acid profile of finishing pigs. A total of 180 Xiangcun Black pigs (initial body weight =70.71 ± 1.21 kg) were randomly allotted to 1 of 5 dietary treatments with six pens of six pigs per pen. The pigs were provided a basal diet or a diet contained 3%, 6%, 9% or 12% of ramie powder during a 50‐day experiment period. The results showed that the inclusion of ramie increased (quadratic, p < 0.05) the average daily gain (ADG) and gain:feed ratio (G:F) with the highest value of ADG and G:F in 3% ramie group, but ramie content in the diet up to 9% reduced the growth performance of the pigs compared with that of 3% ramie group. The activity of serum total superoxide dismutase (SOD) was increased (linear, p < 0.05) by ramie, while content of malondialdehyde was decreased (linear, p < 0.05). As increasing the dietary ramie level, the mRNA expression level of SOD1 was increased quadratically (p < 0.05) in muscle tissues. Moreover, the addition of ramie linearly increased (p < 0.05) polyunsaturated fatty acids content, whereas it linearly reduced (p < 0.05) the lipid indices of atherogenicity (AI) and thrombogenicity (TI) in muscle tissues, and lower values of AI and TI reflect a “healthier” fat composition. The results indicated that ramie in a diet not more than 9% may improve antioxidative capacity with no detrimental impact on growth performance of Chinese native finishing pigs; meanwhile, it could beneficially change the pork fatty acid pattern which has a positive impact on consumer's health.
The alteration history of the Jbilet Winselwan CM carbonaceous chondrite: An analog for C‐type asteroid sample return
Authors: King A. J. , Russell S. S. , Schofield P. F. , Humphreys‐Williams E. R. , Strekopytov S. , Abernethy F. A. J. , Verchovsky A. B. , Grady M. M. 
Published: December 2018

AbstractJbilet Winselwan is one of the largest CM carbonaceous chondrites available for study. Its light, major, and trace elemental compositions are within the range of other CM chondrites. Chondrules are surrounded by dusty rims and set within a matrix of phyllosilicates, oxides, and sulfides. Calcium‐ and aluminum‐rich inclusions (CAIs) are present at ≤1 vol% and at least one contains melilite. Jbilet Winselwan is a breccia containing diverse lithologies that experienced varying degrees of aqueous alteration. In most lithologies, the chondrules and CAIs are partially altered and the metal abundance is low (<1 vol%), consistent with petrologic subtypes 2.7–2.4 on the Rubin et al. () scale. However, chondrules and CAIs in some lithologies are completely altered suggesting more extensive hydration to petrologic subtypes ≤2.3. Following hydration, some lithologies suffered thermal metamorphism at 400–500 °C. Bulk X‐ray diffraction shows that Jbilet Winselwan consists of a highly disordered and/or very fine‐grained phase (73 vol%), which we infer was originally phyllosilicates prior to dehydration during a thermal metamorphic event(s). Some aliquots of Jbilet Winselwan also show significant depletions in volatile elements such as He and Cd. The heating was probably short‐lived and caused by impacts. Jbilet Winselwan samples a mixture of hydrated and dehydrated materials from a primitive water‐rich asteroid. It may therefore be a good analog for the types of materials that will be encountered by the Hayabusa‐2 and OSIRIS‐REx asteroid sample‐return missions.
Plausible Petri nets as self‐adaptive expert systems: A tool for infrastructure asset monitoring
Authors: Chiachío Manuel , Chiachío Juan , Prescott Darren , Andrews John 
Published: December 2018

AbstractThis article provides a computational framework to model self‐adaptive expert systems using the Petri net (PN) formalism. Self‐adaptive expert systems are understood here as expert systems with the ability to autonomously learn from external inputs, like monitoring data. To this end, the Bayesian learning principles are investigated and also combined with the Plausible PNs (PPNs) methodology. PPNs are a variant within the PN paradigm, which are efficient to jointly consider the dynamics of discrete events, like maintenance actions, together with multiple sources of uncertain information about a state variable. The manuscript shows the mathematical conditions and computational procedure where the Bayesian updating becomes a particular case of a more general basic operation within the PPN execution semantics, which enables the uncertain knowledge being updated from monitoring data. The approach is general, but here it is demonstrated in a novel computational model acting as expert system for railway track inspection management taken as a case study using published data from a laboratory simulation of train loading on ballast. The results reveal self‐adaptability and uncertainty management as key enabling aspects to optimize inspection actions in railway track, only being adaptively and autonomously triggered based on the actual learnt state of track and other contextual issues, like resource availability, as opposed to scheduled periodic maintenance activities.
Impact of differential DNA methylation on transgene expression in cotton (Gossypium hirsutum L.) events generated by targeted sequence insertion
Authors: Verkest Aurine , Bourout Stephane , Debaveye Jurgen , Reynaert Kristine , Saey Bernadette , den Brande Ilse Van , D'Halluin Kathleen 
Published: December 2018

SummaryTargeted Genome Optimization (TGO) using site‐specific nucleases to introduce a DNA double‐strand break (DSB) at a specific target locus has broadened the options available to breeders for generation and combination of multiple traits. The use of targeted DNA cleavage in combination with homologous recombination (HR)‐mediated repair, enabled the precise targeted insertion of additional trait genes (2mepsps, hppd, axmi115) at a pre‐existing transgenic locus in cotton. Here we describe the expression and epigenome analyses of cotton Targeted Sequence Insertion (TSI) events over generations. In a subset of events, we observed variability in the level of transgene (hppd, axmi115) expression between independent but genetically identical TSI events. Transgene expression could also be differential within single events and variable over generations. This expression variability and silencing occurred independently of the transgene sequence and could be attributed to DNA methylation that was further linked to different DNA methylation mechanisms. The trigger(s) of transgene DNA methylation remains elusive but we hypothesize that targeted DSB induction and repair could be a potential trigger for DNA methylation.
A New Methodology for Before–After Safety Assessment Using Survival Analysis and Longitudinal Data
Authors: Xie Kun , Ozbay Kaan , Yang Hong , Yang Di 
Published: December 2018

AbstractThe widely used empirical Bayes (EB) and full Bayes (FB) methods for before–after safety assessment are sometimes limited because of the extensive data needs from additional reference sites. To address this issue, this study proposes a novel before–after safety evaluation methodology based on survival analysis and longitudinal data as an alternative to the EB/FB method. A Bayesian survival analysis (SARE) model with a random effect term to address the unobserved heterogeneity across sites is developed. The proposed survival analysis method is validated through a simulation study before its application. Subsequently, the SARE model is developed in a case study to evaluate the safety effectiveness of a recent red‐light‐running photo enforcement program in New Jersey. As demonstrated in the simulation and the case study, the survival analysis can provide valid estimates using only data from treated sites, and thus its results will not be affected by the selection of defective or insufficient reference sites. In addition, the proposed approach can take into account the censored data generated due to the transition from the before period to the after period, which has not been previously explored in the literature. Using individual crashes as units of analysis, survival analysis can incorporate longitudinal covariates such as the traffic volume and weather variation, and thus can explicitly account for the potential temporal heterogeneity.
Use of network analysis multidrug‐resistant tuberculosis contact investigation in Kanchanaburi, Thailand
Authors: Boonthanapat N. , Soontornmon K. , Pungrassami P. , Sukhasitwanichkul J. , Mahasirimongkol S. , Jiraphongsa C. , Monkongdee P. , Angchokchatchawal K. , Wiratsudakul A. 
Published: December 2018

AbstractObjectiveTo characterise MDR‐TB outbreak and incorporate social network analysis with contact investigation to detect case–contact linkages and clusters.MethodsMDR‐TB cases registered in the district hospital between October 2012 and September 2015 were interviewed and their contacts were investigated. A relationship‐based weighted network was constructed.ResultsAmong 43 interviewed MDR‐TB cases, 20 (47%) were male, five (12%) were asymptomatic (and discovered incidentally) and 22 (51%) had underlying diseases. From the documented 115 contacts, 61 (53%) were household contacts and 49 (43%) were close (non‐household) contacts; 70 (61%) were screened for TB using various tests. In this network, we prioritised 37 contacts connected with more than one MDR‐TB patient. The largest cluster was identified in the pharmacy unit of the hospital.ConclusionThis investigation yielded a significant number of MDR‐TB contacts, and social network analysis facilitated the prioritisation for screening. Social network analysis is useful and feasible in this program setting and complements MDR‐TB contact investigation.
Relationship between hospital or surgeon volume and outcomes in joint arthroplasty: protocol for a suite of systematic reviews and dose–response meta-analyses
Authors: Wu Xiang-Dong , Liu Meng-Meng , Sun Ya-Ying , Zhao Zhi-Hu , Zhou Quan , Kwong Joey S W , Xu Wei , Tian Mian , He Yao , Huang Wei 
Published: December 2018

IntroductionJoint arthroplasty is a particularly complex orthopaedic surgical procedure performed on joints, including the hip, knee, shoulder, ankle, elbow, wrist and even digit joints. Increasing evidence from volume–outcomes research supports the finding that patients undergoing joint arthroplasty in high-volume hospitals or by high-volume surgeons achieve better outcomes, and minimum case load requirements have been established in some areas. However, the relationships between hospital/surgeon volume and outcomes in patients undergoing arthroplasty are not fully understood. Furthermore, whether elective arthroplasty should be restricted to high-volume hospitals or surgeons remains in dispute, and little is known regarding where the thresholds should be set for different types of joint arthroplasties.Methods and analysesThis is a protocol for a suite of systematic reviews and dose–response meta-analyses, which will be amended and updated in conjunction with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. Electronic databases, including PubMed and Embase, will be searched for observational studies examining the relationship between the hospital or surgeon volume and clinical outcomes in adult patients undergoing primary or revision of joint arthroplasty. We will use records management software for study selection and a predefined standardised file for data extraction and management. Quality will be assessed using the Newcastle-Ottawa Scale, and the meta-analysis, subgroup analysis and sensitivity analysis will be performed using Stata statistical software. Once the volume–outcome relationships are established, we will examine the potential non-linear relationships between hospital/surgeon volume and outcomes and detect whether thresholds or turning points exist.Ethics and disseminationEthical approval is not required, because these studies are based on aggregated published data. The results of this suite of systematic reviews and meta-analyses will be submitted to peer-reviewed journals for publication.PROSPERO registration numberCRD42017056639.
Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis
Authors: Wu Ziying , Ding Xiang , Lei Guanghua , Zeng Chao , Wei Jie , Li Jiatian , Li Hui , Yang Tuo , Cui Yang , Xiong Yilin , Wang Yilun , Xie Dongxing 
Published: December 2018

ObjectiveTo investigate the efficacy and safety of the pulsed electromagnetic field (PEMF) therapy in treating osteoarthritis (OA).DesignMeta-analysis.Data sourcesPubMed, Embase, the Cochrane Library and Web of Science were searched through 13 October 2017.Eligibility criteria for selecting studiesRandomised controlled trials compared the efficacy of PEMF therapy with sham control in patients with OA.Data extraction and synthesisPain, function, adverse effects and characteristics of participants were extracted. RevMan V.5.2 was used to perform statistical analyses.ResultsTwelve trials were included, among which ten trials involved knee OA, two involved cervical OA and one involved hand OA. The PEMF group showed more significant pain alleviation than the sham group in knee OA (standardised mean differences (SMD)=−0.54, 95% CI −1.04 to –0.04, p=0.03) and hand OA (SMD=−2.85, 95% CI −3.65 to –2.04, p<0.00001), but not in cervical OA. Similarly, comparing with the sham–control treatment, significant function improvement was observed in the PEMF group in both knee and hand OA patients (SMD=−0.34, 95% CI −0.53 to –0.14, p=0.0006, and SMD=−1.49, 95% CI −2.12 to –0.86, p<0.00001, respectively), but not in patients with cervical OA. Sensitivity analyses suggested that the exposure duration <=30 min per session exhibited better effects compared with the exposure duration >30 min per session. Three trials reported adverse events, and the combined results showed that there was no significant difference between PEMF and the sham group.ConclusionsPEMF could alleviate pain and improve physical function for patients with knee and hand OA, but not for patients with cervical OA. Meanwhile, a short PEMF treatment duration (within 30 min) may achieve more favourable efficacy. However, given the limited number of study available in hand and cervical OA, the implication of this conclusion should be cautious for hand and cervical OA.
Is the decline in neonatal mortality in northern Ghana, 1996–2012, associated with the decline in the age of BCG vaccination? An ecological study
Authors: Welaga Paul , Debpuur Cornelius , Aaby Peter , Hodgson Abraham , Azongo Daniel K , Benn Christine S , Oduro Abraham Rexford 
Published: December 2018

ObjectiveTo examine the association between early Bacille Calmette-Guerin (BCG) vaccination and neonatal mortality in northern Ghana.MethodsThis ecological study used vaccination and mortality data from the Navrongo Health and Demographic Surveillance System. First, we assessed and compared changes in neonatal mortality rates (NMRs) and median BCG vaccination age from 1996 to 2012. Second, we compared the changes in NMR and median BCG vaccination age from 2002 to 2012 by delivery place when data on delivery place were available.ResultsNeonatal mortality rates declined from 46 to 12 per 1000 live births between 1996 and 2012 (trend test: p<0.001). Within the same period, median BCG vaccination age declined from 46 to 4 days (trend test: p<0.001). Among home deliveries, BCG vaccination age declined from 39 days in 2002 to 7 days in 2012 (trend test: p<0.001) and neonatal mortality declined by 24/1000 (trend test: p<0.001). Among health facility deliveries, BCG vaccination age was stable around 3 days from 2002 to 2012 (trend test: p=0.49) and neonatal mortality declined by 9/1000 (trend test: p=0.04). In a small study of children whose vaccination cards were inspected within the first 28 days of life, the HR for BCG-vaccinated compared with BCG-unvaccinated children was 0.55 (95% CI 0.12 to 2.40).ConclusionThe data support the hypothesis that early BCG vaccination may be associated with a decrease in neonatal mortality. However, as suggested by WHO, randomised control trials are required to address the question of whether there is indeed a causal association between early BCG vaccination and neonatal mortality.
Definition of whole person care in general practice in the English language literature: a systematic review
Authors: Thomas Hayley , Mitchell Geoffrey , Rich Justin , Best Megan 
Published: December 2018

ObjectivesThe importance of ‘whole person’ or ‘holistic’ care is widely recognised, particularly with an increasing prevalence of chronic multimorbidity internationally. This approach to care is a defining feature of general practice. However, its precise meaning remains ambiguous. We aimed to determine how the term ‘whole person’ care is understood by general practitioners (GPs), and whether it is synonymous with ‘[w]holistic’ and ‘biopsychosocial’ care.DesignSystematic literature review.MethodsMEDLINE, PubMed, EMBASE, CINAHL, PsycINFO, Web of Science, Proquest Dissertations and Theses, Science.gov (Health and Medicine database), Google Scholar and included studies’ reference lists were searched with an unlimited date range. Systematic or literature reviews, original research, theoretical articles or books/book chapters; specific to general practice; relevant to the research question; and published in English were included. Included literature was critically appraised, and data were extracted and analysed using thematic synthesis.ResultsFifty publications were included from 4297 non-duplicate records retrieved. Six themes were identified: a multidimensional, integrated approach; the importance of the therapeutic relationship; acknowledging doctors’ humanity; recognising patients’ individual personhood; viewing health as more than absence of disease; and employing a range of treatment modalities. Whole person, biopsychosocial and holistic terminology were often used interchangeably, but were not synonymous.ConclusionsWhole person, holistic and biopsychosocial terminology are primarily characterised by a multidimensional approach to care and incorporate additional elements described above. Whole person care probably represents the closest representation of the basis for general practice. Health systems aiming to provide whole person care need to address the challenge of integrating the care of other health professionals, and maintaining the patient–doctor relationship central to the themes identified. Further research is required to clarify the representativeness of the findings, and the relative importance GPs’ assign to each theme.PROSPERO registration numberCRD42017058824.
Poor school attendance and exclusion: a systematic review protocol on educational risk factors for self-harm and suicidal behaviours
Authors: Epstein Sophie , Roberts Emmert , Sedgwick Rosemary , Finning Katie , Ford Tamsin , Dutta Rina , Downs Johnny 
Published: December 2018

IntroductionSchools have an important role in recognising and preventing self-harm and suicidal behaviour in their students, however little is known about which educational factors are associated with heightened risk. We will systematically review the existing evidence on two key educational performance indicators that are routinely collected by school administrative systems: school attendance and exclusion. We will investigate their association with self-harm and suicidal behaviour in school-age children and adolescents. Knowledge of this association could help inform suicide prevention strategies at clinical, school and population levels.Methods and analysisWe will conduct a systematic search of Medline, EMBASE, PsycINFO, British Education Index and Education Resources Information Centre (ERIC) from 1 January 1990, and conduct a manual search for additional references. We aim to identify studies that explore the association between poor school attendance or exclusion and self-harm or suicidal behaviours in school-age children and adolescents. Two independent reviewers will screen titles, abstracts and full-text documents and independently extract relevant data for analysis. Study quality will be assessed using a modified Newcastle-Ottawa Scale. A descriptive analysis will be performed, and where appropriate, results will be combined in meta-analyses.Ethics and disseminationThis is a systematic review of published literature, and therefore ethical approval will not be sought. We will publish reports in health and education journals, present our work at conferences focused on school mental health and communicate our findings to practitioners and managers in public health, education and child mental health.PROSPERO registration numberCRD42018088608.