bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fractional order for the transmission dynamics of coffee berry diseases (CBD)
Authors: Fantaye Abayneh Kebede 
Published: November 2024

Abstract
Coffee berry diseases (CBD) pose significant threats to coffee production worldwide, affecting the livelihoods of millions of farmers and the global coffee market. Fractional calculus provides a powerful framework for describing non-local and memory-dependent phenomena, making it suitable for modelling the long-range interactions inherent in CBD spread. This study aims to formulate and analyse fractional order model for CBD transmission dynamics in the sense of Atangana–Baleanu–Caputo. Fixed point theorems were utilised to test the existence and uniqueness of the model’s solutions using fractional order. The basic reproduction number was calculated utilising the next-generation matrix. The model has locally asymptotically stable equilibrium positions (disease-free and endemic). Furthermore, the Lyapunov function was used to conduct a global stability analysis of the equilibrium locations. A numerical simulation of the CBD model was created using the fractional Adam–Bashforth–Moulton approach to validate the analytical findings. Our findings contribute to the development of more accurate predictive models and inform the design of targeted interventions to mitigate the impact of CBD on coffee production systems.
Psychological Type and Temperament Profile of Anglican Clergy Serving in the Episcopal Church (USA)
Authors: Francis Leslie J. , Village Andrew 
Published: November 2024

Abstract
The present study drew on data provided by 179 clergymen and 226 clergywomen to discuss the psychological type and temperaments profile of stipendiary parochial clergy serving in The Episcopal Church (USA) and to set this profile alongside 591 clergymen and 486 clergywomen serving in the Church of England. The data indicated a similar profile for Anglican clergy on both sides of the Atlantic, with preferences for introversion, intuition, feeling and judging. In terms of temperament, in the USA 41% of clergymen were SJ, 38% NF, 17% NT and 4% SP; 43% of clergywomen were NF, 41% SJ, 13% NT and 2% SP.
A high FBR low SAR and AMC-backed compact wearable antenna array for WBAN applications
Authors: Chu Jun , Du Chengzhu , Shu Haifeng 
Published: November 2024

Abstract
In this paper, a wearable antenna array based on a 9 × 3 artificial magnetic conductor (AMC) array is proposed with the characteristics of compact, low profile, low specific absorption rate (SAR), high front-to-back ratio (FBR) and high gain for wireless body area network (WBAN) bands. The proposed wearable antenna consists of a four-element array and an AMC array. The size of antenna array loaded AMC is 137.7 × 45.9 mm2. The dielectric substrate of the antenna and the AMC structure are made of 0.1 mm liquid crystal polymer material, which is flexible and low profiled. The antenna operates from 5.62 to 6 GHz after the AMC structure is loaded. The gain increases by 3.23 dB, reaching 12.03 dB at 5.8 GHz. And the FBR value is raised by 26.04 dB. The highest SAR value of the simulated antenna on the human model is 0.0496 W/kg, far less than the US federal or EU requirements. After constructing and testing the antenna, the outcomes of the tests agreed with the results of the simulation. The flexible antenna array with AMC structure has good prospect in WBAN applications.
A longitudinal birth cohort study of child maltreatment and mental disorders using linked statewide child protection and administrative health data for 83,050 Queensland residents from 1983 to 2014
Authors: Kisely Steve , Leske Stuart , Ogilvie James , Thompson Carleen , Siskind Dan , Allard Troy 
Published: November 2024

Abstract

Aims
Most information about the association between childhood maltreatment (CM) and subsequent psychiatric morbidity is based on retrospective self-reports. Findings from longitudinal studies using prospective reports to statutory agencies may be subject to attrition. We therefore compared the prevalence to age 30 of inpatient psychiatric diagnoses in those who experienced agency-reported CM with those of the rest of the cohort using administrative data to minimise loss to follow-up.

Methods
We used linked administrative data for two birth cohorts of all individuals born in Queensland, Australia in 1983 and 1984 (N = 83,050) and followed to age 30 years. This was the entire cohort aside from 312 people who died. Information on CM came from statewide child protection data and psychiatric diagnoses from all public and private hospital admissions in Queensland.

Results
On adjusted analyses, the 4,703 participants (5.7%) who had been notified to the statewide child protection authority had three to eight times the odds of being admitted for any of the following psychiatric diagnoses by age 30 years old: schizophrenia-spectrum disorders, bipolar affective disorders, depression, anxiety and post-traumatic stress disorders (PTSD). There were similar findings for all the CM subtypes. Associations were especially strong for PTSD with between a seven – and nine-fold increase in the odds of admission.

Conclusions
This is one of the largest studies of the long-term effects of CM, covering an entire jurisdiction. All types of maltreatment are significantly related to a range of psychiatric disorders requiring hospitalisation. Early identification, intervention and providing appropriate support to individuals who have experienced CM may help mitigate the long-term consequences and reduce the risk of subsequent mental health problems.
Enhanced Ocean Mixing During the Passage of Tropical Cyclone
Authors: Falor Devang , Gayen Bishakhdatta , Sengupta Debasis , Chaudhuri Dipanjan 
Published: November 2024

AbstractTropical cyclones are among the most destructive natural disasters. However, lack of detailed observations and the simplifications inherent in operational ocean models, lead to incomplete knowledge of underlying ocean processes. Using high‐fidelity large‐eddy simulations and moored observations away from the storm track, we show that mutually interacting shear and convective processes, govern the evolving state of the upper ocean. Our simulation agrees well with observed sea surface temperature and sea surface salinity. Shear driven turbulence due to surface wind stress erodes stratification, deepens the ocean mixed layer and transports freshwater into the mixed layer during rain events. Concurrently, surface buoyancy loss also aids in ocean mixing via convective entrainment. The mixing efficiency and the associated eddy diffusivity shows high spatiotemporal variability throughout the water column during cyclone passage. Thus, a better insight into the upper ocean mixing mechanisms is necessary for developing improved mixing parameterizations for tropical cyclone intensity forecasts.
Copper homeostasis and cuproptosis in central nervous system diseases
Authors: Zhu Zhipeng , Song Min , Ren Jianxun , Liang Lirong , Mao Guohua , Chen Min 
Published: November 2024

AbstractCopper (Cu), an indispensable micronutrient for the sustenance of living organisms, contributes significantly to a vast array of fundamental metabolic processes. The human body maintains a relatively low concentration of copper, which is mostly found in the bones, liver, and brain. Despite its low concentration, Cu plays a crucial role as an indispensable element in the progression and pathogenesis of central nervous system (CNS) diseases. Extensive studies have been conducted in recent years on copper homeostasis and copper-induced cell death in CNS disorders, including glioma, Alzheimer’s disease, Amyotrophic lateral sclerosis, Huntington’s disease, and stroke. Cuproptosis, a novel copper-induced cell death pathway distinct from apoptosis, necrosis, pyroptosis, and ferroptosis, has been identified as potentially intricately linked to the pathogenic mechanisms underlying various CNS diseases. Therefore, a systematic review of copper homeostasis and cuproptosis and their relationship with CNS disorders could deepen our understanding of the pathogenesis of these diseases. In addition, it may provide new insights and strategies for the treatment of CNS disorders.
Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids
Authors: Kluiver Thomas A. , Lu Yuyan , Schubert Stephanie A. , Kraaier Lianne J. , Ringnalda Femke , Lijnzaad Philip , DeMartino Jeff , Megchelenbrink Wouter L. , Amo-Addae Vicky , Eising Selma , de Faria Flavia W. , Münter Daniel , van de Wetering Marc , Kerl Kornelius , Duiker Evelien , van den Heuvel Marius C. , de Meijer Vincent E. , de Kleine Ruben H. , Molenaar Jan J. , Margaritis Thanasis , Stunnenberg Hendrik G. , de Krijger Ronald R. , Zsiros József , Clevers Hans , Peng Weng Chuan 
Published: November 2024

AbstractHepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize this heterogeneity and identify novel targeted therapies, we perform comprehensive analysis of hepatoblastomas and tumor-derived organoids using single-cell RNA-seq/ATAC-seq, spatial transcriptomics, and high-throughput drug profiling. We identify two distinct tumor epithelial signatures: hepatic ‘fetal’ and WNT-high ‘embryonal’, displaying divergent WNT signaling patterns. The fetal group is enriched for liver-specific WNT targets, while the embryonal group is enriched in canonical WNT target genes. Gene regulatory network analysis reveals enrichment of regulons related to hepatic functions such as bile acid, lipid and xenobiotic metabolism in the fetal subtype but not in the embryonal subtype. In addition, the dichotomous expression pattern of the transcription factors HNF4A and LEF1 allows for a clear distinction between the fetal and embryonal tumor cells. We also perform high-throughput drug screening using patient-derived tumor organoids and identify sensitivity to HDAC inhibitors. Intriguingly, embryonal and fetal tumor organoids are sensitive to FGFR and EGFR inhibitors, respectively, indicating a dependency on EGF/FGF signaling in hepatoblastoma tumorigenesis. In summary, our data uncover the molecular and drug sensitivity landscapes of hepatoblastoma and pave the way for the development of targeted therapies.
Characterizing the interactions between influenza and respiratory syncytial viruses and their implications for epidemic control
Authors: Kramer Sarah C. , Pirikahu Sarah , Casalegno Jean-Sébastien , Domenech de Cellès Matthieu 
Published: November 2024

AbstractPathogen-pathogen interactions represent a critical but little-understood feature of infectious disease dynamics. In particular, experimental evidence suggests that influenza virus and respiratory syncytial virus (RSV) compete with each other, such that infection with one confers temporary protection against the other. However, such interactions are challenging to study using common epidemiologic methods. Here, we use a mathematical modeling approach, in conjunction with detailed surveillance data from Hong Kong and Canada, to infer the strength and duration of the interaction between influenza and RSV. Based on our estimates, we further utilize our model to evaluate the potential conflicting effects of live attenuated influenza vaccines (LAIV) on RSV burden. We find evidence of a moderate to strong, negative, bidirectional interaction, such that infection with either virus yields 40-100% protection against infection with the other for one to five months. Assuming that LAIV reduces RSV susceptibility in a similar manner, we predict that the impact of such a vaccine at the population level would likely depend greatly on underlying viral circulation patterns. More broadly, we highlight the utility of mathematical models as a tool to characterize pathogen-pathogen interactions.
Saturation of the compression of two interacting magnetized plasma toroids evidenced in the laboratory
Authors: Sladkov A. , Fegan C. , Yao W. , Bott A. F. A. , Chen S. N. , Ahmed H. , Filippov E. D. , Lelièvre R. , Martin P. , McIlvenny A. , Waltenspiel T. , Antici P. , Borghesi M. , Pikuz S. , Ciardi A. , d’Humières E. , Soloviev A. , Starodubtsev M. , Fuchs J. 
Published: November 2024

AbstractInteractions between magnetic fields advected by matter play a fundamental role in the Universe at a diverse range of scales. A crucial role these interactions play is in making turbulent fields highly anisotropic, leading to observed ordered fields. These in turn, are important evolutionary factors for all the systems within and around. Despite scant evidence, due to the difficulty in measuring even near-Earth events, the magnetic field compression factor in these interactions, measured at very varied scales, is limited to a few. However, compressing matter in which a magnetic field is embedded, results in compression up to several thousands. Here we show, using laboratory experiments and matching three-dimensional hybrid simulations, that there is indeed a very effective saturation of the compression when two independent parallel-oriented magnetic fields regions encounter one another due to plasma advection. We found that the observed saturation is linked to a build-up of the magnetic pressure, which decelerates and redirects the inflows at their encounter point, thereby stopping further compression. Moreover, the growth of an electric field, induced by the incoming flows and the magnetic field, acts in redirecting the inflows transversely, further hampering field compression.
Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes
Authors: Cheng Shiya , Schuh Melina 
Published: November 2024

AbstractIn mammals, oocytes are arrested in prophase of meiosis I for long periods of time. Prophase arrest is critical for reproduction because it allows oocytes to grow to their full size to support meiotic maturation and embryonic development. Prophase arrest requires the inhibitory phosphorylation of the mitotic kinase CDK1. Whether prophase arrest is also regulated at the translational level is unknown. Here, we show that prophase arrest is regulated by translational control of dormant cyclin B1 mRNAs. Using Trim-Away, we identify two mechanisms that maintain cyclin B1 dormancy and thus prophase arrest. First, a complex of the RNA-binding proteins DDX6, LSM14B and CPEB1 directly represses cyclin B1 translation through interacting with its 3’UTR. Second, cytoplasmic poly(A)-binding proteins (PABPCs) indirectly repress the translation of cyclin B1 and other poly(A)-tail-less or short-tailed mRNAs by sequestering the translation machinery on long-tailed mRNAs. Together, we demonstrate how RNA-binding proteins coordinately regulate prophase arrest, and reveal an unexpected role for PABPCs in controlling mRNA dormancy.
Switchable topological polar states in epitaxial BaTiO3 nanoislands on silicon
Authors: Olaniyan Ibukun , Tikhonov Iurii , Hevelke Valentin Väinö , Wiesner Sven , Zhang Leifeng , Razumnaya Anna , Cherkashin Nikolay , Schamm-Chardon Sylvie , Lukyanchuk Igor , Kim Dong-Jik , Dubourdieu Catherine 
Published: November 2024

AbstractA fascinating aspect of nanoscale ferroelectric materials is the emergence of topological polar textures, which include various complex and stable polarization configurations. The manipulation of such topological textures through external stimuli like electric fields holds promise for advanced nanoelectronics applications. There are, however, several challenges to reach potential applications, among which reliably creating and controlling these textures at the nanoscale on silicon, and with lead-free compounds. We report the realization of epitaxial BaTiO3 nanoislands on silicon, with a lateral size as small as 30-60 nm, and demonstrate stable center down-convergent polarization domains that can be reversibly switched by an electric field to center up-divergent domains. Piezoresponse force microscopy data reconstruction and phase field modeling give insight into the 3D patterns. The trapezoidal-shape nanoislands give rise to center down-convergent lateral swirling polarization component with respect to the nanoisland axis, which prevents the formation of bound charges on the side walls, therefore minimizing depolarization fields. The texture resembles a swirling vortex of liquid flowing into a narrowing funnel. Chirality emerges from the whirling polarization configurations. The ability to create and electrically manipulate chiral whirling polar textures in BaTiO3 nanostructures grown monolithically on silicon holds promise for applications in future topological nanoelectronics.
Genetic variants associated with longevity in long-living Indians
Authors: Pemmasani Sandhya Kiran , R G Shakthiraju , V Suraj , Bhattacharyya Raunaq , Patel Chetan , Gupta Anil Kumar , Acharya Anuradha 
Published: November 2024

AbstractGenetic factors play a significant role in determining an individual’s longevity. The present study was aimed at identifying genetic variants associated with longevity in Indian population. Long living individuals (LLIs), aged 85+, were compared with younger controls, aged 18-49 years, using data from GenomegaDB, a genetic database of Indians living in India. An in-house developed custom chip, having variants associated with various cancers, cardiovascular, neurological, gastro-intestinal, metabolic and auto-immune disorders, was used to generate genotype data. Logistic regression analysis with sex and top three genetic principal components as covariates resulted in 9 variants to be significantly associated with longevity at a p-value threshold of 5 × 10−4. Alleles associated with slower heart rate (rs365990, MYH6), decreased risk of osteoporosis and short body height (rs2982570, ESR1), decreased risk of schizophrenia (rs1339227, RIMS1-KCNQ5) and decreased risk of anxiety and neuroticism (rs391957, HSPA5) were found to have higher frequency in LLIs. Alleles associated with increased risk of atrial fibrillation (rs3903239, GORAB-PRRX1) and biliary disorders (rs2002042, ABCC2) were found to have lower frequency. The G allele of rs2802292 from FOXO3A gene, associated with longevity in Japanese, German and French centenarians, was also found to be significant in this population (P = 0.032). Pathway enrichment analysis revealed that the genes involved in oxidative stress, apoptosis, DNA damage repair, glucose metabolism and energy metabolism were significantly involved in affecting the longevity. Results of our study demonstrate the genetic basis of healthy aging and longevity in the population.
Diagnostic efficacy and clinical utility of whole-exome sequencing in Czech pediatric patients with rare and undiagnosed diseases
Authors: Slaba Katerina , Pokorna Petra , Jugas Robin , Palova Hana , Prochazkova Dagmar , Aulicka Stefania , Spanelova Klara , Danhofer Pavlina , Horak Ondrej , Tuckova Jana , Kleiblova Petra , Gaillyova Renata , Hrunka Matej , Jouza Martin , Pinkova Blanka , Papez Jan , Konecna Petra , Zidkova Jana , Stourac Petr , Sterba Jaroslav , Demlova Regina , Demlova Eva , Jabandziev Petr , Slaby Ondrej 
Published: November 2024

AbstractIn the last decade, undiagnosed disease programs have emerged to address the significant number of individuals with suspected but undiagnosed rare genetic diseases. In our single-center study, we have launched a pilot program for pediatric patients with undiagnosed diseases in the second-largest university hospital in the Czech Republic. This study was prospectively conducted at the Department of Pediatrics at University Hospital Brno between 2020 and 2023. A total of 58 Czech patients with undiagnosed diseases were enrolled in the study. All children underwent singleton WES with targeted phenotype-driven analysis. We identified 28 variants, including 11 pathogenic, 13 likely pathogenic, and 4 VUS according to ACMG guidelines, as diagnostic of genetic diseases in 25 patients, resulting in an overall diagnostic yield of 43%. Eleven variants were novel and had not been previously reported in any public database. The overall clinical utility (actionability) enabling at least one type of change in the medical care of the patient was 76%, whereas the average number of clinical implications to individual patient care was two. Singleton WES facilitated the diagnostic process in the Czech undiagnosed pediatric population. We believe it is an effective approach to enable appropriate counseling, surveillance, and personalized clinical management.
Adaptive morphing of wing and tail for stable, resilient, and energy-efficient flight of avian-inspired drones
Authors: Jeger Simon Luis , Wüest Valentin , Toumieh Charbel , Floreano Dario 
Published: November 2024

AbstractAvian-inspired drones feature morphing wing and tail surfaces, enhancing agility and adaptability in flight. Despite their large potential, realising their full capabilities remains challenging due to the lack of generalized control strategies accommodating their large degrees of freedom and cross-coupling effects between their control surfaces. Here we propose a new body-rate controller for avian-inspired drones that uses all available actuators to control the motion of the drone. The method exhibits robustness against physical perturbations, turbulent airflow, and even loss of certain actuators mid-flight. Furthermore, wing and tail morphing is leveraged to enhance energy efficiency at 8 m/s, 10 m/s, and 12 m/s using in-flight Bayesian optimization. The resulting morphing configurations yield significant gains across all three speeds of up to 11.5% compared to non-morphing configurations and display a strong resemblance to avian flight at different speeds. This research lays the groundwork for the development of autonomous avian-inspired drones that operate under diverse wind conditions, emphasizing the role of morphing in improving energy efficiency.
Digital twin‐based production logistics resource optimisation configuration method in smart cloud manufacturing environment
Authors: Zhang Zhongfei , Qu Ting , Zhang Kai , Zhao Kuo , Zhang Yongheng , Liu Lei , Liang Jianhua , Huang George Q. 
Published: November 2024

AbstractTo adapt to the dynamic, diverse, and personalised needs of customers, manufacturing enterprises face the challenge of continuously adjusting their resource structure. This has led manufacturers to shift towards a smart cloud manufacturing mode in order to build highly flexible production logistics (PL) systems. In these systems, the optimal configuring of PL resources is fundamental for daily logistics planning and vehicle scheduling control, providing necessary resources for the entire PL segment. However, traditional resource configuration methods face limitations, such as incomplete information acquisition, slow response in resource configuration, and suboptimal configuration results, leading to high subsequent operational costs and inefficient logistics transportation. These issues limit the performance of the PL system. To address these challenges, the authors propose a digital twin‐based optimisation model and method for smart cloud PL resources. The approach begins with constructing an optimisation model for the PL system considering the quality of service for a cloud resource is constructed, aiming to minimise the number of logistics vehicles and the total cost of the PL system. Additionally, a DT‐based decision framework for optimising smart cloud PL resources is proposed. Alongside a DT‐based dynamic configuration strategy for smart cloud PL resources is designed. By developing a multi‐teacher grouping teaching strategy and a cross‐learning strategy, the teaching and learning strategies of the standard teaching‐learning‐based optimisation algorithm are improved. Finally, numerical simulation experiments were conducted on the logistics transportation process of a cooperating enterprise, verifying the feasibility and effectiveness of the proposed algorithms and strategies. The findings of this study provide valuable references for the management of PL resources and algorithm design in advanced manufacturing modes.