bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer Potential of Pulicaria crispa Extract on Human Breast Cancer MDA-MB-231 Cells
Authors: Barnawi Ibrahim Omar , Ali Imran 
Published: July 2019

Background:Breast cancer is the common cause of deaths among women globally with 15% mortality globally.Introduction:Today, about 80% of the rural population depends on natural products as primary health care. Pulicaria crispa (L., family Compositae) is utilized in traditional medicine for curing colds, coughs, colic, and excessive sweating and as a carminative.Methods:The extracts of Pulicaria crispa; grown in Saudi Arabia; were assessed to measure the cytotoxicity with MDA-MB-231 breast cancer cell lines. Soxhlet extraction was utilized for stem, leaves and flower with 70% ethanol. The cytotoxicity of the extracts with MDA-MB-231 breast cancer cells was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays.Results:The apoptotic cellular morphological alterations were detected by fluorescence microscopes. The results indicated that Pulicaria crispa exhibited a strong anticancer activity with a halfmaximal inhibitory concentration (IC50) of 180 µg/mL against breast cancer cells. The loss in cell integrity, shrinkage of cytoplasm, and cell detachment were seen in the extract treated with MDAMB- 231 cells. The cell death was due to membrane destruction.Conclusion:Pulicaria crispa extracts indicated significant cytotoxicity against human breast cancer cells (MDA-MB-231 cells). The extract of this plant may be given to the patients having breast cancer.
Evaluation of Terpene Variability in the Volatile Oils from Zingiber officinale using Chemometrics
Authors: Jahiddin Farah S.A. , Low Kah Hin 
Published: July 2019

Background:
Ginger oil poses various pharmacological properties corresponding to its
terpene composition which depends upon the preparation method along with the sample variety.

Objecive:
This work aims to explore the variability in the derived oil associated with the hydrodistillation
settings i.e. sample freshness/dryness, size reduction process, and heating duration using
chemometric approaches.

Methods:
The extraction process was evaluated with a two-level full factorial design where the volatile
oils were hydrodistillated and characterized by gas chromatographic-mass spectrometry. The
multivariate dataset ascertained was further explored with principal component analysis.

Results:
According to the outcomes from the design, the yield could be quantitatively improved by
using fresh sample, with reduced particle thickness and longer extraction cycle. The clastering patterns
from principal component analysis revealed the domination of monoterpenes in the extracts
from fresh samples; sesquiterpenes in the grated samples; whereas heating duration demonstrated antagonistic
effect between monoterpenes and sesquiterpenes.

Conclusion:
These findings suggest the importance of experimental conditions in driving the yield
and quality of ginger extracts according to the requirement of the industries.
Carbon Nitride Nanosheet and Myoglobin Modified Electrode for Electrochemical Sensing Investigations
Authors: Deng Ying , Wen Zuorui , Luo Guiling , Xie Hui , Liu Juan , Xi Yaru , Li Guangjiu , Sun Wei 
Published: July 2019

Background:
Carbon-based nanomaterials, especially carbon nitride (C3N4) has attracted
tremendous interest in biosensor applications. Meanwhile, the mechanism of redox protein sensing
and related electrocatalytic reactions can provide a valid basis for understanding the process of biological
redox reaction.

Objective:
The aim of this paper is to construct a new electrochemical enzyme sensor to achieve direct
electron transfer of myoglobin (Mb) on CILE surface and display electrocatalytic reduction activity
to catalyze trichloroacetic acid (TCA) and H2O2.

Methods:
The working electrode was fabricated based on ionic liquid modified Carbon Paste Electrode
(CILE) and C3N4 nanosheets were modified on the CILE surface, then Mb solution was fixed
on C3N4/CILE surface and immobilized by using Nafion film. The as-prepared biosensor displayed
satisfactory electrocatalytic ability towards the reduction of TCA and H2O2 in an optimum pH 7.0
buffer solution.

Results:
The results indicated that C3N4 modified electrode retained the activity of the enzyme and
displayed quasi-reversible redox behavior in an optimum pH 7.0 buffer solution. The electrochemical
parameters of the immobilized Mb on the electrode surface were further calculated with the results of
the electron transfer number (n) as 1.27, the charge transfer coefficient (α) as 0.53 and the electrontransfer
rate constant (ks) as 3.32 s-1, respectively. The Nafion/Mb/C3N4/CILE displayed outstanding
electrocatalytic reduction activity to catalyze trichloroacetic acid and H2O2.

Conclusion:
The Nafion/Mb/C3N4/CILE displayed outstanding electrocatalytic reduction, which
demonstrated the promising applications of C3N4 nanosheet in the field electrochemical biosensing.
Optimization of Extraction Parameters of Reverse Iontophoretic Determination of Blood Glucose in an Artificial Skin Model
Authors: Yengin Cigdem , Kilinc Emrah , Der Fatma Gulay , Sezgin Mehmet Can , Alcin Ilayda 
Published: July 2019

Background:
Reverse İontophoresis (RI) is one of the promising non-invasive technologies.
It relies on the transition of low magnitude current through the skin and thus glucose measurement
becomes possible as it is extracted from the surface during this porter current flow.

Objective:
This paper deals with the development and optimization of an RI determination method
for glucose. CE dialysis membrane based artificial skin model was developed and the dependence of
RI extraction on various experimental parameters was investigated.

Method:
Dependence of RI extraction performance on noble electrodes (platinum, silver, palladium,
ruthenium, rhodium) was checked with CA, CV and DPV, in a wide pH and ionic strength range.
Optimizations on inter-electrode distance, potential type and magnitude, extraction time, gel type,
membrane MWCO, usage frequency, pretreatment, artificial body fluids were performed.

Results:
According to the optimized results, the inter-electrode distance was 7.0 mm and silver was
the optimum noble metal. Optimum pH and ionic strength were achieved with 0.05M PBS at pH 7.4.
Higher glucose yields were obtained with DPV, while CA and CV achieved almost the same levels.
During CA, +0.5V achieved the highest glucose yield and higher potential even caused a decrease.
Glucose levels could be monitored for 24 hours. CMC gel was the optimum collection media. Pretreated
CE membrane with 12kD MWCO was the artificial skin model. Pretreatment affected the yields
while its condition caused no significant difference. Except PBS solution (simulated as artificial
plasma), among the various artificial simulated body fluids, intestinal juice formulation (AI) and urine
formulation U2 were the optimum extraction media, respectively.

Conclusion:
In this study, various experimental parameters (pretereatment procedure, type and
MWCO values of membranes, inter-electrode distance, electrode material, extraction medium solvents,
ionic strength and pH, collection medium gel type, extraction potential type and magnitude,
extraction time and etc) were optimized for the non-invasive RI determination of glucose in a CE dialysis
membrane-based artificial skin model and various simulated artificial body fluids.
Prevalence and Characteristics of Twitter Posts About Court-Ordered, Tobacco-Related Corrective Statements: Descriptive Content Analysis
Authors: Kelley Dannielle E , Brown Meredith , Murray Alice , Blake Kelly D 
Published: July 2019

Background
Three major US tobacco companies were recently ordered to publish corrective statements intended to prevent and restrain further fraud about the health effects of smoking. The court-ordered statements began appearing in newspapers and on television (TV) in late 2017.

Objective
The objective of this study was to examine the social media dissemination of the tobacco corrective statements during the first 6 months of the implementation of the statements.

Methods
We conducted a descriptive content analysis of Twitter posts using an iterative search strategy through Crimson Hexagon and randomly selected 19.74% (456/2309) of original posts occurring between November 1, 2017, and March 27, 2018, for coding and analysis. We assessed post volume over time, source or author, valence, linked content, and reference to the industry (eg, big tobacco, tobacco industry, and Philip Morris) and media outlet (TV or newspaper). Retweeted content was coded for source/author and prevalence.

Results
Most posts were published in November 2017, surrounding the initial release of the corrective statements. Content was generally neutral (58.7%, 268/456) or positive (33.3%, 152/456) in valence, included links to additional information about the statements (94.9%, 433/456), referred to the industry (87.7%, 400/456), and did not mention a specific media channel on which the statements were aired or published (15%). The majority of original posts were created by individual users (55.2%, 252/456), whereas the majority of retweeted posts were posted by public health organizations (51%). Differences by source are reported, for example, organization posts are more likely to include a link to additional information compared with individual users (P=.03).

Conclusions
Conversations about the court-ordered corrective statements are taking place on Twitter and are generally neutral or positive in nature. Public health organizations may be increasing the prevalence of these conversations through social media engagement.
PENGARUH PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE NUMBERED HEADS TOGETHER (NHT) TERHADAP PEMAHAMAN KONSEP IPA FISIKA SISWA KELAS VII SMP MUHAMMADIYAH 6 PADANG
Authors: Wulansari Egi 
Published: July 2019

Penelitian ini dilatarbelakangi oleh kurangnya ketelitian dan tanggung jawab siswa dalam mengerjakan tugas serta rendahnya pemahaman konsep IPA Fisika siswa kelas VII SMP Muhammadiyah 6 Padang. Jenis penelitian ini adalah quasi eksperiment, dengan desain penelitian posttest only control group design. Populasi dalam penelitian ini adalah siswa kelas VII SMP Muhammadiyah 6 Padangyang terdiri dari 3 kelas. Teknik pengambilan sampel dilakukan dengan teknik cluster random sampling, penentuan kelas sampel dilakukan secara acak. Berdasarkan hasil analisis data, diketahui bahwa kelas sampel terdistribusi normal dan memiliki variansi yang homogen. Hasil uji hipotesis diperoleh dengan menggunakan uji satu pihak diperoleh t hitung = 1,94 dan t tabel = 1,67. Data yang diperoleh t hitung > t tabel = 1,94 > 1,67 maka hipotesis diterima. Jadi dapat disimpulkan bahwa pemahaman konsep IPA Fisika siswa dengan menerapkan pembelajaran kooperatif tipe NHT lebih baik dari pada pemahaman konsep IPA Fisika siswa dengan menerapkan pembelajaran konvensional siswa kelas VII SMP Muhammadiyah 6 Padang.Kata Kunci : Model Pembelajaran Kooperatif, Number Heads Together (NHT), Pemahaman Pembelajaran Fisika
PENGARUH PENERAPAN TEKA TEKI SILANG DALAM PEMBELAJARAN DISCOVERY LEARNING TERHADAP HASIL BELAJAR FISIKA SISWA KELAS XI MIPA SMA NEGERI 14 PADANG
Authors: Rahmini Yumila , Anaperta Megasyani , Yanti Iing Rika 
Published: July 2019

Penelitian ini dilatarbelakangi rendahnya hasil belajar Fisika siswa karena masih kurangnya minat belajar siswa saat proses pembelajaran. Untuk mengatasi masalah tersebut penulis melakukan pembelajaran dengan menerapkan teka-teki silang. Penilaian pada ranah kognitif yaitu melalui tes akhir, pada ranah afektif melalui lembar observasi siswa dan pada ranah psikomotor menggunakan lembar penilaian psikomotor siswa. Teknik analisis data hasil belajar yaitu dengan menggunakan uji t, dan kemudian dilakukan perhitungan effect size untuk menentukan seberapa besar pengaruh yang diberikan. Berdasarkan dari perhitungan effect size diperoleh d sebesar 0,69 tergolong kedalam sedang. Jadi berdasarkan nilai rata-rata hasil belajar fisika siswa, pengaruh penggunaan teka-teki silang dalam pembelajaran discovery learning berpengaruh sedang dalam meningkatkan hasil belajar fisika kelas XI MIPA SMAN 14 Padang. Kata kunci : Pembelajaran Fisika, Teka-teki Silang, Discovery Learning, Hasil Belajar Fisika
ULUSAL GASTRONOMİ KİMLİĞİNİN GELİŞTİRİLMESİ VE TURİSTİK TANITIMINDA KARŞILAŞILAN SORUNLAR
Authors: BULUT Samuray Hakan 
Published: July 2019

Bu çalışma gastronomi biliminin merkezde tutulduğu ulusal
düzeyde yapılmış akademik turizm araştırmalarının incelenmesi sonucu elde
edilen bilgiler ışığında; Türkiye’nin turizm potansiyelinin, ülkenin gastronomi
kimliği öne çıkarılarak arttırılması ve tanıtılması noktasında karşılaşılan
sorunları belirlemek amacıyla hazırlanmıştır. Araştırmada genel çerçevede
gastronomi bilimi hakkında bilinmesi gerekenler, yerel gastronomi ögelerinin
güncellenerek bilinirliklerinin arttırılması, coğrafi işaretleme kavramının
anlamlandırılması, turist rehberlerinin gastronomi bilgi-birikimleri, turizm
pazarlamasında gastronomi ve mutfak sanatlarının rolü, lisans düzeyinde
gastronomi eğitimi, gastronominin üretim-servis-tüketim aşamaları, bölgesel
gastronomi, yerli turistlerin gastronomi turizmine katkıları, gastronominin
sanatsal boyutu gibi sayısız başlık
altında toplanması mümkün olan konularda, ülkemizde yapılmış bir çok akademik
çalışmanın değerlendirilmesiyle elde edilen ve ulusal gastronomi kimliğinin
turistik tanıtımda daha güçlü kullanılmasına engel teşkil ettiği düşünülen
problemlerin üzerinde durulmuştur.
Быть или не быть генеральным планам крупных городов
Authors: Gertsberg Lora 
Published: July 2019

Статья написана в рамках дискуссии, возникшей в результате поручения В.В. Путина правительству за­менить генпланы крупных городов на стратегические планы для ускорения градостроительного обеспечения строительства. Мнения специалистов по данному во­просу разделились. Для того чтобы оценить целесо­образность такого решения анализируется опыт про­ектирования крупных российских городов в условиях плановой экономики. Также анализируется современный опыт Англии, включая законодательную базу в области стратегического градостроительного планирования, опыт разработки стратегического Плана Большого Лон­дона и локального плана города Лондона. Проведённый анализ позволяет прийти к выводу о том, что крупный город должен иметь стратегический план развития. Он включает видение, или миссию города, набор стратегий в разных сферах жизнедеятельности города (жилищная, промышленная, инфраструктурная, экологическая и др.), определение согласованной политики их пространствен­ной реализации, общей концепции пространственного развития города, направленных на достижение миссии города. Стратегический план крупного города должен разрабатываться на территорию города и прилегающие территории, с которыми осуществляется активная по­вседневная связь. Он должен иметь социальное и ре­сурсное обоснование, механизмы реализации, содержать показатели, по которым осуществляется мониторинг этой реализации. Основная цель этого плана не уско­рить градостроительное обеспечение строительства, а способствовать формированию успешного города: ком­фортного, привлекательного для инвестиций, жителей и приезжих. Наличие стратегического плана не исключает необходимость разработки генеральных планов на круп­ные административнотерриториальные образования в рамках планируемой территории с целью детализации определённой для них стратегии. Эффективность планов зависит от применения современных технологий разра­ботки решений и управления их реализацией, а также от того, насколько социально и экономически обосновано видение города.
PENGARUH MODEL PEMBELAJARAN ADVANCE ORGANIZER TERHADAP KEMAMPUAN SISWA MENGANALISIS MATERI BENTUK MOLEKUL KELAS X IPA SMA NEGERI 10 KOTA JAMBI
Authors: Suharti Kiki 
Published: July 2019

Penelitian ini dilatarbelakangi oleh kesulitan yang dialami siswa diantaranya kesulitan dalaM menganalisis materi bentuk molekul dan kesulitan menghubungkan rumus-rumus penentuan bentuk molekul. Penerapan model pembelajaran yang tepat merupakan salah satu alternatif untuk mengatasi masalah tersebut. Salah satu model pembelajaran yang dapat diterapkan adalah model pembelajaran advance organizer. Penelitian ini bertujuan untuk mengetahui adanya pengaruh model pembelajaran advance organizer terhadap kemampuan siswa menganalisis materi bentuk molekul kelas X IPA SMA Negeri 10 Kota Jambi. Jenis penelitian yang dilakukan adalah Quasi-Eksperimen dengan desain the matching-only posttest only control group design. Teknik pengambilan sampel dilakukan dengan purposive sampling. Instrumen yang digunakan yaitu lembar observasi keterlaksanaan model oleh guru dan siswa serta tes kemampuan siswa menganalisis. Pengujian hipotesis dengan uji t untuk melihat keterlaksanaan model pembelajaran advance organizer dengan kemampuan siswa menganalisis. Metode t-test yang digunakan berjenis polled varian. Keterlaksanaan model pembelajaran advance organizer oleh guru sebesar 35,33% (baik) dan siswa sebesar 29,51% (cukup baik). Hubungan keterlaksanaan model advance organizer dan kemampuan siswa menganalisis diperoleh rxy= 0,5038 dengan tingkat hubungan pada kategori sedang dan uji t sebesar 3,92, sehingga hipotesis penelitian (Ha) diterima. Hasil analisis data tes kemampuan siswa menganalisis materi bentuk molekul, kedua kelas sampel memiliki distribusi normal dan varian homogen, pada uji-t diperoleh thitung = 3,91 dan ttabel = 1,998 dengan dk 64 dan a = 0,05, maka thitung > ttabel atau (3,91 > 1,998) dengan dk=32+34-2=64, pada derajat signifikan 95%. Berdasarkan hasil penelitian, disimpulkan bahwa terdapat perbedaan antara pembelajaran dengan menggunakan model advance organizer dan model direct instruction terhadap kemampuan siswa menganalisis pada materi bentuk molekul di kelas X SMAN 10 Jambi.
KOMPETENSI GURU PENDIDIKAN ISLAM DALAM PENGELOLAAN PEMBELAJARAN DI MADRASAH ALIYAH AS’ADIYAH PUTERI SENGKANG KABUPATEN WAJO
Authors: Hairi Falihal 
Published: July 2019

Abstrak Hasil penelitian menunjukkan bahwa 1) Kompetensi pedagogik guru pendidikan Islam di Madrasah Aliyah As’adiyah Puteri Sengkang Kabupaten Wajo belum maksimal, yang berkaitan dengan tugas fungsinya sebagai guru, guru hendaknya menguasai teori belajar dan prinsip kegiatan pembelajaran, dan mampu menerapkan berbagai pendekatan, strategi, metode, dan teknik pembelajaran yang mendidik secara kreatif dalam mata pelajaran yang diampuh. 2) Guru pendidikan Islam dalam pengelolaan pembelajaran di Madrasah Aliyah As’adiyah Puteri Sengkang Kabupaten Wajo, masih diperlukan efektivitas yang lebih optimal agar keberhasilan pembelajaran dapat tercapai dengan baik dan operasional guru mata pelajaran pendidikan Islam, terlihat dari upaya guru untuk melaksanakan perencanaan, pelaksanaan dan evaluasi terutama yang berkenaan dengan perangkat pembelajaran, diperlukan model pembelajaran sesuai dengan tuntutan isi dan hasil yang diharapkan. 3) Faktor pendukung guru pendidikan Islam dalam pengelolaan pembelajaran di Madrasah Aliyah As’adiyah Puteri Sengkang yaitu ketersediaan perangkat pembelajaran, prasarana Madrasah, dan fungsi yang mendukung kegiatan pembelajaran. Faktor penghambat guru pendidikan Islam dalam pengelolaan pembelajaran di Madrasah Aliyah As’adiyah Puteri Sengkang yaitu keterbatasan jam pelajaran, kedisiplinan guru dan sarana belajar Madrasah.
Nationwide survey on the current practice of ventricular tachycardia ablation
Authors: Vergara Pasquale , Casella Michela , Barbato Gaetano , De Ruvo Ermenegildo , Grandinetti Giuseppe , Notarstefano Pasquale , Tola Gianfranco , Calvi Valeria , Santini Luca , Nissardi Vincenzo , Nonis Alessandro , Ricci Renato P. , Boriani Giuseppe , Tondo Claudio , Della Bella Paolo 
Published: July 2019

Methods
We performed a nationwide survey on the current practice of ventricular tachycardia catheter ablation in Italy during the year 2016.

Results
Among 145 operators participating in the survey, 58 (40.0%) did not perform any ventricular tachycardia ablation in 2016. Among those performing ventricular tachycardia ablation, 9 operators (6.2%) performed only right ventricular endocardial catheter ablation, 52 (35.9%) performed endocardial catheter ablation both in the right and left ventricle (LV) and 26 (17.9%) performed both endocardial and epicardial LV catheter ablations. Seventy operators (89.7%) among the 78 performing LV and epicardial ablations treated patients with ischemic cardiomyopathy; ablations in the setting of other causes were less frequently performed. The following were considered as minimum requirements for ventricular tachycardia ablation: presence of a three-dimensional mapping system (120 operators, 82.8%), ICU in the hospital (118 operators, 81.4%), operator's training in high volume centers (93 operators, 64.1%). Twenty-eight operators (19.3%) performed catheter ablation in patients with electrical storm only after hemodynamic stabilization, 41 operators (28.3%) also during the acute phase and 9 operators (6.2%) never performed catheter ablation in electrical storm patients; the remaining 67 operators did not perform ventricular tachycardia ablation at all, or performed ablations only in the right ventricle.

Conclusion
The present survey provides a snapshot of the current invasive treatment of ventricular tachycardia by catheter ablation. The procedure, especially in the setting of ischemic cardiomyopathy, is performed nationwide. Complex cases, including those with electrical storm, should be managed within a preestablished integrated network of regional referral centers able to transfer patients as soon as possible.
Structural and functional peculiarities of the endothelium of heart vessels of mature rats according to immunistochemical studies
Authors: Chumasov E. I. , Petrova E. S. , Korzhevskii D. E. 
Published: July 2019

The relevance of the study is connected with the modern point of view that endothelial dysfunction may be the cause of such socially significant diseases as atherosclerosis, diabetes, varicose veins, etc. The aim of the work is to study the morphofunctional peculiarities of the endothelium of the cardiovascular vessels of the mature rat using Willebrand factor (vWF) immunohistochemistry.Material and methods. We used mature Wistar rats (n = 12). Polyclonal rabbit antibodies were used for the immunohistochemical detection of vWF. The reaction was carried out on paraffin sections, made through the whole heart.Results. It was shown that the immunopositive reaction to vWF (vWF+ ) in the endothelium of different regions of the rat heart is not uniform. A tendency was found to weaken the vWF+ reaction in the direction from the base of the heart to its apex. Most functionally active endothelial cells with signs of exocytosis were observed in the aortic root, the large coronary arteries of the epicardium, the fibrous ring, the valves and the subaortal cone. vWF+ was less pronounced in the endothelium lining the atrial and ventricular cavities and in the myocardial capillaries.Conclusions. Using immunohistochemical detection of the vWF, the endothelium features of different parts of the rat heart were identified. Structural features due to increased secretion of vascular endothelial cells of the heart were revealed. Further research in this direction may be important to explain the mechanisms and diagnosis of endothelial dysfunction.