bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of an ultrasound-guided approach to radiofrequency ablation of the superolateral, superomedial and inferomedial genicular nerves: a cadaveric study
Authors: Vanneste Bert , Tomlinson Joanna , Desmet Matthias , Krol Andrzej 
Published: August 2019

IntroductionGenicular nerve radiofrequency (RF)denervation appears to be a promising treatment for knee pain in patients with degenerative osteoarthritis of the knee, when candidates are not suitable for arthroplasty. This study aimed to assess the accuracy and reliability of ultrasound-guided placement of RF cannulas in cadavers for genicular nerve treatment, by measuringthe needle-to-nerve proximity.Materials and methodsFive soft-fix human cadavers were included in this study, totaling 10 knees (meanage 93.8 years). Using the ultrasound-guided technique,which we have described previously, RF cannulas were directed toward the superolateral genicular nerve(SLGN), the superomedial genicular nerve (SMGN) and the inferomedial genicular nerve (IMGN). Indocyaninegreen (ICG) dye (0.1 mL) was infiltrated. An anatomical dissection was performed and the distance from the center of the ICG mark to the genicular nerve concerned was measured.ResultsThe mean distances from the center of the ICG mark to the SLGN, SMGN and IMGN were 2.33 mm(range 0.00–6.05 mm), 3.44 mm (range 0.00–10.59mm) and 1.32 mm (range 0.00–2.99 mm), respectively. There was no statistical difference in distances from the center of the ICG mark to the targeted nerve between the different nerves (p=0.18).ConclusionThe results of this study demonstrate that ultrasound-guided treatment of the genicular nerves is feasible. However, for RF ablations, there are some limitations, which mostly can be overcome by using appropriate RF ablation settings.
Efficacy of a newN-(n-butyl) thiophosphoric triamide formulation in reducing ammonia volatilization from urea-based fertilizers
Authors: Lasisi Ahmed A. , Akinremi Olalekan O. , Kumaragamage Darshani 
Published: August 2019

N-(n-Butyl)thiophosphoric triamide (NBPT) has been reported to reduce ammonia volatilization from surface-applied urea and urea ammonium nitrate (UAN). A new NBPT formulation (ARM U™, 18% NBPT) that contains a polymer allowing for lower application rate of NBPT was evaluated for its efficacy relative to Agrotain®(30% NBPT) and Arborite®(24% NBPT). Trials consisted of (i) a greenhouse study that compared two rates of ARM U-treated urea (360 and 540 mg NBPT kg−1urea) with Arborite- or Agrotain-treated urea (480 and 600 mg NBPT kg−1urea, respectively) and (ii) a field study that compared urea and UAN treated with either ARM U (360 mg NBPT kg−1urea) or Agrotain (600 mg NBPT kg−1urea) at two sites. Static chambers fitted with acid-charged discs were used to measure ammonia volatilization at six or seven dates over 28 d. In the greenhouse study, ammonia volatilization was reduced by 96% with either ARM U or Agrotain and 95% with Arborite. In the field study, ARM U and Agrotain reduced ammonia volatilization from urea by 80% and 66%, respectively, across sites. Similarly, ammonia volatilization from UAN was reduced by 46% and 60% with ARM U and Agrotain, respectively. Despite the lower NBPT application rates with ARM U, ammonia reduction by ARM U, Agrotain, and Arborite was not significantly different. The addition of ARM U to urea and UAN enabled lower application rate of NBPT without compromising its efficacy.
CD47 Expression Defines Efficacy of Rituximab with CHOP in Non–Germinal Center B-cell (Non-GCB) Diffuse Large B-cell Lymphoma Patients (DLBCL), but Not in GCB DLBCL
Authors: Bouwstra Renée , He Yuan , de Boer Janneke , Kooistra Hilde , Cendrowicz Ewa , Fehrmann Rudolf S.N. , Ammatuna Emanuele , zu Eulenburg Christine , Nijland Marcel , Huls Gerwin , Bremer Edwin , van Meerten Tom 
Published: August 2019

Abstract
Addition of rituximab (R) to “CHOP” (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy improved outcome for diffuse large B-cell lymphoma (DLBCL) patients. Approximately 40% of patients who receive R-CHOP still succumb to disease due to intrinsic resistance or relapse. A potential negative regulator of DLBCL treatment outcome is the CD47 “don't eat me” immune checkpoint. To delineate the impact of CD47, we used a clinically and molecularly well-annotated cohort of 939 DLBCL patients, comprising both germinal center B-cell (GCB) and non-GCB DLBCL subtypes, treated with either CHOP or R-CHOP. High (above median) CD47 mRNA expression correlated with a detrimental effect on overall survival (OS) when DLBCL patients received R-CHOP therapy (P = 0.001), but not CHOP therapy (P = 0.645). Accordingly, patients with low CD47 expression benefited most from the addition of rituximab to CHOP [HR, 0.32; confidence interval (CI), 0.21–0.50; P &lt; 0.001]. This negative impact of high CD47 expression on OS after R-CHOP treatment was only evident in cancers of non-GCB origin (HR, 2.09; CI, 1.26–3.47; P = 0.004) and not in the GCB subtype (HR, 1.16; CI, 0.68–1.99; P = 0.58). This differential impact of CD47 in non-GCB and GCB was confirmed in vitro, as macrophage-mediated phagocytosis stimulated by rituximab was augmented by CD47-blocking antibody only in non-GCB cell lines. Thus, high expression of CD47 mRNA limited the benefit of addition of rituximab to CHOP in non-GCB patients, and CD47-blockade only augmented rituximab-mediated phagocytosis in non-GCB cell lines. Patients with non-GCB DLBCL may benefit from CD47-targeted therapy in addition to rituximab.
Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model
Authors: Narayanan Jayanth S. Shankara , Ray Partha , Hayashi Tomoko , Whisenant Thomas C. , Vicente Diego , Carson Dennis A. , Miller Aaron M. , Schoenberger Stephen P. , White Rebekah R. 
Published: August 2019

Abstract
Irreversible electroporation (IRE) is a nonthermal ablation technique that is used clinically in selected patients with locally advanced pancreatic cancer, but most patients develop recurrent distant metastatic disease. We hypothesize that IRE can induce an in situ vaccination effect by releasing tumor neoantigens in an inflammatory context. Using an immunocompetent mouse model, we demonstrated that IRE alone produced complete regression of subcutaneous tumors in approximately 20% to 30% of mice. IRE was not effective in immunodeficient mice. Mice with complete response to IRE demonstrated prophylactic immunity and remained tumor free when rechallenged with secondary tumors on the contralateral flank. CD8+ T cells from IRE-responsive mice were reactive against peptides representing model-inherent alloantigens and conferred protection against tumor challenge when adoptively transferred into immunocompromised, tumor-naïve mice. Combining IRE with intratumoral Toll-like receptor-7 (TLR7) agonist (1V270) and systemic anti-programmed death-1 receptor (PD)-1 checkpoint blockade resulted in improved treatment responses. This combination also resulted in elimination of untreated concomitant distant tumors (abscopal effects), an effect not seen with IRE alone. These results suggest that the systemic antitumor immune response triggered by IRE can be enhanced by stimulating the innate immune system with a TLR7 agonist and the adaptive immune system with anti–PD-1 checkpoint blockade simultaneously. Combinatorial approaches such as this may help overcome the immunosuppressive pancreatic cancer microenvironment.
Inappropriate Left Ventricular Mass and Cardiovascular Disease Events and Mortality in Blacks: The Jackson Heart Study
Authors: Anstey D. Edmund , Tanner Rikki M. , Booth John N. , Bress Adam P. , Diaz Keith M. , Sims Mario , Ogedegbe Gbenga , Muntner Paul , Abdalla Marwah 
Published: August 2019

Background

Left ventricular hypertrophy (
LVH
) is associated with an increased risk for cardiovascular disease (
CVD
) events and all‐cause mortality. Many individuals without
LVH
have a left ventricular mass that exceeds the level predicted by their sex, body size, and cardiac workload, a condition called inappropriate left ventricular mass (
iLVM
). We investigated the association of
iLVM
with
CVD
events and all‐cause mortality among blacks.

Methods and Results

We analyzed data from the Jackson Heart Study, a community‐based cohort of blacks. The current analysis included 4424 participants without
CVD
and with an echocardiogram at baseline. Among this cohort, the prevalence of
iLVM
was 13.8%. There were 262
CVD
events and 419 deaths over a median follow‐up of 9.7 years (maximum, 12 years). Compared with participants without
iLVM
, participants with
iLVM
had a higher rate of
CVD
events and all‐cause mortality. After multivariable adjustment, including for the presence of
LVH
,
iLVM
was associated with an increased risk of
CVD
events (hazard ratio, 1.87; 95%
CI
, 1.33–2.62). The multivariable‐adjusted hazard ratio for all‐cause mortality was 1.29 (95%
CI
, 0.98–1.70). Among participants without and with
LVH
, the multivariable‐adjusted hazard ratios of
iLVM
for
CVD
events were 2.53 (95%
CI
, 1.68–3.81) and 1.21 (95%
CI
, 0.74–2.00), respectively (
P
interaction
=0.029); and for all‐cause mortality, the hazard ratios were 1.24 (95%
CI
, 0.81–1.89) and 1.26 (95%
CI
, 0.86–1.85), respectively (
P
interaction
=0.664).

Conclusions

iLVM
is associated with an increased risk for
CVD
events among blacks without
LVH
.
Younger Age and Depressive Symptoms Predict High Risk of Generalized Anxiety After Stroke and Transient Ischemic Attack
Authors: Kapoor Arunima , Si Kevin , Yu Amy Y.X. , Lanctot Krista L. , Herrmann Nathan , Murray Brian J. , Swartz Richard H. 
Published: August 2019

Background and Purpose—
Depression and anxiety are common after stroke/transient ischemic attack (TIA). These conditions are associated with poor functional outcome and worse quality of life. However, few studies have explored predictors of poststroke risk of generalized anxiety, especially in patients without comorbid depressive symptoms. We aimed to explore predictors of high risk of generalized anxiety after stroke/TIA.

Methods—
Consecutive stroke and TIA referrals to the Sunnybrook Stroke Prevention Clinic over a 2-year period (April 2012–April 2014) who spoke English, were not severely aphasic, and who consented to complete neuropsychological testing were included in this analysis. Generalized anxiety and depressive symptoms were assessed using the Generalized Anxiety Disorder 7-item scale and Center for Epidemiological Studies Depression Scale, respectively.

Results—

Two hundred and fifty-eight patients completed the Generalized Anxiety Disorder 7-item scale, of whom 56 (22%) were at high risk for generalized anxiety (scores ≥10). Younger age (odds ratio=0.96; 95% CI, 0.93–0.99;
P
=0.004) and greater depressive symptoms (odds ratio=1.20; 95% CI, 1.14–1.26;
P
≤0.001) were significant predictors of being at high risk for generalized anxiety after stroke/TIA. Younger patients (≤50 years) were significantly more likely to be at high risk for both depression and generalized anxiety than older patients (30% versus 12%, χ
2
[1, N=258]=10.98,
P
=0.001). Our model explained 56% of the variance in risk of generalized anxiety after stroke. In patients without severe depressive symptoms (n=193, 75%), age and severity of depressive symptoms remained the only factors associated with risk of generalized anxiety.

Conclusions—
Anxiety is common after stroke/TIA and is highly correlated with poststroke depressive symptoms and age, even among those without severe depressive symptoms. Given the greater frequency of both generalized anxiety and depressive symptoms in young survivors, routine screening for depression and further evaluation of anxiety after stroke/TIA is warranted.
Melting Lizards and Solid Gold Stop Signs: Preferential Recall of Both Counterintuitive and Bizarre Concepts
Authors: Easker Makena J. , Keniston Allen H. 
Published: August 2019

AbstractResearch has shown that minimally counterintuitive concepts (MCI) are more memorable than concepts that are simply bizarre. However, this disparity may exist only in studies using cross-cultural samples. To test the impact of bizarreness on culturally homogeneous populations, we read a fictional narrative to 33 college-age students at a Midwestern university. This narrative featured 18 sets of target items – six which were intuitive, six which were counterintuitive, and six which were bizarre. After hearing the story, experimenters administered a written recall task. As hypothesized, students did not differ in their recall of counterintuitive or bizarre target items. Therefore, we propose a minimally distinctive model of memorability, encompassing both counterintuitiveness and bizarreness. This model may help us better understand the memorability of expectation violations, especially those within religious stories.
Christ in the Banlieues
Authors: Oliphant Elayne 
Published: August 2019

Abstract
In this essay, I analyze the efforts of a French Roman Catholic organization committed to reproducing the ubiquity of Roman Catholic built space in the landscapes of Paris and its suburbs. Over its nearly 100-year-existence, the “Cardinal’s Construction Site” has variously advertised its efforts as those necessary to combat communism, modernism, and secular apathy. I argue that its labors demonstrate how two concepts central to the anthropological study of Roman Catholicism exist in powerful tension. While Roman Catholicism has the capacity to recede into the background—in part through the ubiquity of its built space—and appear as nothing more than the unmarked or normative culture in countries in which it is the majority religion, its power as a social “institution” is maintained by numerous practices that invoke the “passions.” That is, in order to uphold the status that allows it to go unmarked, Roman Catholicism must also function as what Valentina Napolitano has described as a “passionate machine.” It is in part Catholicism’s capacity to uphold the normative by way of the passions that explains its current role in the xenophobic politics of Europe in the present.
Catholic Globalism in the United States
Authors: Kaell Hillary 
Published: August 2019

Abstract
Inspired by Norget, Napolitano, and Mayblin’s suggestion that anthropologists attend more closely to the mechanisms of Catholicism’s worldwide spread, this article juxtaposes two organizations—the Holy Childhood Association and Unbound—to explore “paganism,” conversion, and its legacy among U.S. laypeople. In the process, it makes two major points. The first concerns the recourse to “culture” as a rhetorical and ideational hinge connecting the singularity of Christian universalism and new valuations of local multiplicity. The second focuses on the U.S. Catholic relationship to institutional structures of missionary work, which they both associate with positive attributes of a vibrant society, while also being much more critical than their Protestant counterparts of their own Church’s role abroad. It ends by noting how Unbound and its supporters contend with ongoing inequalities by cultivating an imagined global parity where Catholic people choose to send their “gifts” to each other.
Higher Emotional Awareness Is Associated With Reduced Pain in Irritable Bowel Syndrome Patients: Preliminary Results
Authors: Smith Ryan , Gudleski Gregory D. , Lane Richard D. , Lackner Jeffrey M. 
Published: August 2019

Objective Recent evidence indicates that interventions designed to improve emotional awareness reduce pain in irritable bowel syndrome. This preliminary study sought to determine whether trait emotional awareness is associated with typical pain in patients with irritable bowel syndrome. Methods Healthy volunteers ( n =  66) and irritable bowel syndrome patients ( n =  50) were asked to self-report their typical levels of pain intensity and complete both the Levels of Emotional Awareness Scale and the Somatization Scale of the Brief Symptom Inventory. Results Levels of Emotional Awareness Scale scores in irritable bowel syndrome patients did not differ from scores in healthy participants; however, higher Levels of Emotional Awareness Scale scores in irritable bowel syndrome patients predicted lower levels of typical pain intensity ( r(45) = −.36, p = .01, 95% CI [−.59, −.08]) and lower levels of somatization ( r(45)= −.31, p = .03, 95% CI [−.55, −.02]). Conclusions This inverse relationship between emotional awareness and both pain and somatization symptoms is consistent with evidence that irritable bowel syndrome patients experience reduced pain from therapies designed to improve emotional awareness. The Levels of Emotional Awareness Scale could potentially be used to identify patients who could benefit from such therapy and could potentially be a moderator of response to efficacious psychological therapies.
How does a 4-week motor–cognitive training affect choice reaction, dynamic balance and cognitive performance ability? A randomized controlled trial in well-trained, young, healthy participants
Authors: Niederer Daniel , Plaumann Ulrike , Seitz Tanja , Wallner Franziska , Wilke Jan , Engeroff Tobias , Giesche Florian , Vogt Lutz , Banzer Winfried 
Published: August 2019

Background: We aimed to investigate the potential effects of a 4-week motor–cognitive dual-task training on cognitive and motor function as well as exercise motivation in young, healthy, and active adults. Methods: A total of 26 participants (age 25 ± 2 years; 10 women) were randomly allocated to either the intervention group or a control group. The intervention group performed a motor–cognitive training (3×/week), while the participants of the control group received no intervention. Before and after the intervention period of 4 weeks, all participants underwent cognitive (d2-test, Trail Making Test) and motor (lower-body choice reaction test and time to stabilization test) assessments. Following each of the 12 workouts, self-reported assessments (rating of perceived exertion, enjoyment and pleasant anticipation of the next training session) were done. Analyses of covariances and 95% confidence intervals plotting for between group and time effects were performed. Results: Data from 24 participants were analysed. No pre- to post-intervention improvement nor a between-group difference regarding motor outcomes (choice-reaction: F = 0.5; time to stabilization test: F = 0.7; p > 0.05) occurred. No significant training-induced changes were found in the cognitive tests (D2: F = 0.02; Trail Making Test A: F = 0.24; Trail Making Test B: F = 0.002; p > 0.05). Both enjoyment and anticipation of the next workout were rated as high. Discussion: The neuro-motor training appears to have no significant effects on motor and cognitive function in healthy, young and physically active adults. This might be explained in part by the participants’ very high motor and cognitive abilities, the comparably low training intensity or the programme duration. The high degree of exercise enjoyment, however, may qualify the training as a facilitator to initiate and maintain regular physical activity. The moderate to vigorous intensity levels further point towards potential health-enhancing cardiorespiratory effects.
Allogeneic reactivity–mediated endothelial cell complications after HSCT: a plea for consensual definitions
Authors: Pagliuca Simona , Michonneau David , Sicre de Fontbrune Flore , Sutra del Galy Aurélien , Xhaard Aliénor , Robin Marie , Peffault de Latour Régis , Socie Gérard 
Published: August 2019

Abstract
Endothelial cell (EC) activation has been suspected of triggering a group of rare and dismal complications that can occur after allogeneic hematopoietic stem cell transplantation (HSCT). Capillary leak syndrome, engraftment syndrome, transplant-associated microangiopathy, diffuse alveolar hemorrhage, and idiopathic pneumonia syndrome are the main nosological entities. Post-HSCT endotheliitis can be triggered by chemotherapy, infections, and calcineurin inhibitors, but allogeneic reactivity is claimed to be the common denominator. Endothelial damages are thought to activate several deleterious pathways (proapoptotic, procoagulant, proinflammatory) and can lead to multiorgan failure; however, clinical manifestations of each syndrome overlap, and their relationship with graft-versus-host disease could be minimal. The lack of well-defined diagnostic criteria does not allow for a clear-cut comparison in the current literature. Therapeutic efforts have been made to intercept the pathogenic mechanisms leading to EC dysfunction, but remission rates and survival remain mostly unsatisfactory. In this article, we have reviewed the incidence, clinical features, and treatment approaches of EC activation syndromes, and we plead for the development of internationally accepted standard definitions.
Determining the clinical knowledge and practice of Australian podiatrists on children with developmental coordination disorder: a cross‐sectional survey
Authors: Smith Mitchell , Banwell Helen A. , Ward Emily , Williams Cylie M. 
Published: August 2019

AbstractBackgroundDevelopmental coordination disorder (DCD) is a common condition in children affecting motor coordination. This impacts on academic performance, and activities of daily living. Literature surrounding interventions for DCD has focused mostly on physical and occupational therapies. However, it is known that children with DCD present to podiatrists as these children often also have abnormalities in lower limb functioning associated with the condition. This study aimed to determine current knowledge of Australian podiatrists regarding presentation, assessment, and management of children with developmental coordination disorder.MethodsA single‐round survey, developed using SurveyMonkey®, was completed by a sample of Australian podiatrists. Data were collected through either online or paper means. Participants were asked about their familiarity with DCD and depending on their response, were directed via skip logic to questions on presentation, assessment and management strategies of DCD in children. Participants were also asked about their willingness and preferences for further education on DCD. Descriptive statistics were used to describe the data.ResultsThere were 365 Australian podiatrists who completed the survey. There were 30% (n = 109) who reported being familiar with DCD as a diagnosis, while a further 37% (n = 134) reported familiarity with alternate or outdated terminology associated with the DCD diagnosis. Participants who were familiar with DCD or terminology relating to DCD, showed good knowledge of signs and symptoms associated with DCD. Both familiar and unfamiliar participants favoured referral to other health professionals over completing assessments. Common podiatric management strategies such as footwear advice, orthoses, and strength training were the most frequently chosen by both groups, despite current evidence only supporting strength training as an intervention. Participants were willing to receive education on DCD through a range of both online and in‐person mediums.ConclusionThe majority of Australian podiatrists were unfamiliar with DCD, despite its prevalence and symptomology falling within the podiatric scope. However, participants did overwhelmingly show willingness to receive further education on DCD. Further research should consider understanding the role of podiatrists in the assessment and management of children with DCD and the impact of the type of treatment strategies that may be provided.