bluuebunny/crossref_metadata_2025_split huggingface dataset:
The degree practices for mathematics teachers STEM education
Authors: Alkhateeb Mohammad Ahmad 
Published: October 2018

The study aimed to investigate the teaching practices for mathematics teachers based on science, technology, engineering and mathematics (STEM) in Jordan. Descriptive analytical approach was used through observing the teachersâ€™ teaching in accordance with STEM. The study sample encompassed 30 teachers of mathematics in Zarqa city who were chosen randomly. The study results showed there are seven behaviours performed by the mathematics teachers in a medium degree consistent with STEM, and 14 behaviours by low-grade mathematics teachers are consistent with STEM. The results also revealed that there were not any differences between those practices attributed to qualifications and years of experience variables.
Keywords: Mathematics teachers, science, technology, engineering and mathematics (STEM), scientific qualifications, experience.
To STEM or not to STEM? That is not the question
Authors: Kubat Ulas , Guray Ersan 
Published: October 2018

The aim of this study is to identify the faults in Science, Technology, Engineering and Mathematics (STEM) education and to provide an approach to how these deficiencies can be eliminated. The STEM approach can provide students with an interdisciplinary point of view to gain creativity, critical thinking, high-level skills of thinking and problem-solving. STEM abbreviation consists of the initials of the words â€˜Scienceâ€™, â€˜Technologyâ€™, â€˜Engineeringâ€™ and â€˜Mathematicsâ€™. Conventional educational systems dictate student to learn specific topics separately and expect from them to make these knowledge and experience useful, functional in their life. In this research, a qualitative research method was used. This study was performed by using document analysis method. A novel, integrated education system called as the STEM is investigated with its methodology and problems in application outcoming so far. The importance of such an integrated programme is highlighted and some remedies to create an effective integrated education programme are emphasised.
Keywords: STEM education, integrated programmes, interdisciplinary education.
Pharmacophore Modeling and Docking Studies to Investigate Potential Leads for the Development of β -Secretase APP Cleavage Enzyme-1 (BACE-1) Inhibitors
Authors: Arya Richa , Gupta Satya Prakash , Paliwal Sarvesh , Sharma Swapnil , Madan Kirtika , Chauhan Monika 
Published: October 2018

Background:
Alzheimer’s disease is a medical condition with detrimental brain health. It is
majorly diagnosed in aging individuals plaque in β) characterized by accumulated Amyloidal beta (A
1 BACE) 1 secretase APP cleavage enzyme βneurological areas. The ) is the target of choice that can
be exploited to find drugs against Alzheimer’s disease.

Methods:
A series of BACE-1 inhibitors with reported binding constant were considered for the development
of a feature based pharmacophore model.

Results:
The good correlation coefficient (r=0.91) and RMSD of 0.93 was observed with 30 compounds
in training set. The model was validated internally (r2test=0.76) as well as externally by Fischer validation.
The pharmacophore based virtual screening retrieved compounds that were docked and biologically
evaluated.

Conclusion:
The three structurally diverse molecules were tested by in-vitro method. The pyridine
derivative with highest fit value (6.9) exhibited IC50 value of 2.70 µM and thus was found to be the most
promising lead molecule as BACE-1 inhibitor.
Consensus Docking in Drug Discovery
Authors: Poli Giulio , Tuccinardi Tiziano 
Published: October 2018

Background:
Molecular docking is probably the most popular and profitable approach in
computer-aided drug design, being the staple technique for predicting the binding mode of bioactive
compounds and for performing receptor-based virtual screening studies. The growing attention received
by docking, as well as the need for improving its reliability in pose prediction and virtual screening
performance, has led to the development of a wide plethora of new docking algorithms and scoring
functions. Nevertheless, it is unlikely to identify a single procedure outperforming the other ones in
terms of reliability and accuracy or demonstrating to be generally suitable for all kinds of protein targets.

Methods:
In this context, consensus docking approaches are taking hold in computer-aided drug design.
These computational protocols consist in docking ligands using multiple docking methods and then
comparing the binding poses predicted for the same ligand by the different methods. This analysis is
usually carried out calculating the root-mean-square deviation among the different docking results obtained
for each ligand, in order to identify the number of docking methods producing the same binding
pose.

Results:
The consensus docking approaches demonstrated to improve the quality of docking and virtual
screening results compared to the single docking methods. From a qualitative point of view, the improvement
in pose prediction accuracy was obtained by prioritizing ligand binding poses produced by a
high number of docking methods, whereas with regards to virtual screening studies, high hit rates were
obtained by prioritizing the compounds showing a high level of pose consensus.

Conclusion:
In this review, we provide an overview of the results obtained from the performance assessment
of various consensus docking protocols and we illustrate successful case studies where consensus
docking has been applied in virtual screening studies.
Secoiridoid Amarogentin from ‘Gentianaceae’ with their Health Promotion, Disease Prevention and Modern Analytical Aspects
Authors: Patel Kanika , Patel Dinesh K. 
Published: October 2018

Background:
Plant-based products and their derivatives have been widely used in the medicine,
nutraceuticals, and the cosmetic and pharmaceutical field for a very long time. A large number of
important drugs of modern medicine have also been derived from the plant's sources. Plant products
specifically the pure phytochemical also known as ‘biomarkers’ have been used in the food and pharmaceutical
industries. Biomarker compounds are pure phytochemical and they are mainly responsible
for various pharmacological activities of plant material and examples of biomarker are Amarogentin,
Vasicine, Hyoscyamine and Paclitaxel.

Methods:
Various literature databases were searched to collect important information about Amarogentin
in this review. Ethnomedicinal uses, pharmacological activities, phytochemical aspects and modern
analytical tools of amarogentin were presented and discussed. Further, all the collected information’s
were categorized into different section as per the need of the manuscripts. Moreover, data were also
presented in the graphical abstract, Figures and Table section too.

Results:
Swertia chirata (S. chirata) is a common plant of Gentianaecae family which is mainly known
for their bitter taste. Gentiopicroside, amarogentin, swertiamarin, isovitexin and isogentisin are some
important phytoconstituents of S. chirata. Decoction, infusion, pastes and juice of S. chirata are basically
used in the medicine. Various Pharmacological activities such as hypoglycemic, antimicrobial,
antimalarial, antihepatotoxic, anticarcinogenic, antioxidative and anti-inflammatory have been reported
in the literature for S. chirata plant. Amarogentin, a bitter secoiridoid glycoside of S. chirata has been
well known for antibacterial, anticholinergic anti-lieshmanial, chemopreventive, antihepatitis and anticancer
activities.

Conclusion:
Information provided in the present paper regarding phytochemistry, pharmacological uses
and analytical aspects including bioavailability will be beneficial to various disciplines of biological
science. Development of plant tissue culture-based approaches is also needed for the proper conservation
of S. chirayita plants in the future.
Praksis pembelajaran kewirausahaan pada unit produksi jasa boga
Authors: Mahfud Tuatul 
Published: October 2018

Penelitian bertujuan menemukan konsepsi guru tentang pembelajaran kewirausahaan, kompetensi kewirausahaan yang dikembangkan pada unit produksi sekolah dalam bidang jasa boga. Penelitian ini menggunakan metode kualitatif jenis studi kasus. Subjek penelitian adalah kepala sekolah, ketua program studi, kepala unit produksi, dan siswa. Data dikumpulkan melalui wawancara, observasi, dan dokumentasi dan dianalisis menggunakan model interaktif dari Miles dan Huberman yang terdiri dari reduksi data, data display, dan kesimpulan. Hasil penelitian menunjukkan bahwa: (1) belajar kewirausahaan memerlukan kegiatan nyata (hands-on) dengan melibatkan siswa pada kegiatan usaha yang nyata dalam unit produksi; (2) kompetensi kewirausahaan dikembangkan melalui unit produksi adalah: pengetahuan tentang kewirausahaan melalui pengetahuan diri dan pengetahuan praktis; sikap kewirausahaan meliputi etos kerja, disiplin, kemandirian, dan kreativitas, keterampilan berkomunikasi, keterampilan konseptual, keterampilan pengambilan keputusan, keterampilan mengatur waktu, keterampilan kepemimpinan. Model pembelajaran kewirausahaan yang dikembangkan melalui unit produksi adalah: produksi luar dan produksi dalam, dan kantin mobil. Evaluasi dan monitoring dilakukan melalui dua cara, dengan monitoring kinerja dan produk. PRAXIS OF ENTREPRENEURSHIP LEARNING IN THE CATERING SERVICES PRODUCTION UNITAbstractThe Praxis of Entrepreneurship Learning in the Food services Production Unit. This study aims to investigate teachers’ concepts of entrepreneurship learning, entrepreneurship competencies developed in the production unit, and entrepreneurship learning processes in the production unit of food services in SMK Negeri 6 Yogyakarta. This study employed the qualitative case study. The research subjects were the principal, head of the study program, head of the production unit, and students. Data were collected through interviews, observations, and documentation. The collected data were analyzed using Miles and Huberman model consisting of data reduction, data display, and conclusion. The result shows that: (1) Entrepreneurship learning needs hands-on-experiences-based; (2) the entrepreneurship competency developed through the production unit includes a) entrepreneurship knowledge, consisting of self-knowledge and practical knowledge, b) entrepreneurship attitudes, consisting of work ethos, autonomy, discipline, creativity, and innovativeness, and c) entrepreneurship skills, consisting of: technical skill, human relations skill, conceptual skill, decision making skill, time management skill, and leadership skill; (3) no instructional standard employed in to develop entrepreneurship in production unit. There are three entrepreneurship learning models employed in the production unit: inside production, outside production, and mobile canteen. The learning outcome is measured in two ways, i.e. performance and product monitoring. Meanwhile, evaluation of the students’ learning progress is conducted by using profit-based evaluation.
Pentingnya kelas kewirausahaan pada SMK Pariwisata
Authors: Lastariwati Badraningsih 
Published: October 2018

Kajian ini dimaksudkan untuk menentukan peran kelas kewirausahaan dalam menanamkan jiwa kewirausahaan, nilai, dan pengalaman siswa SMK Tata Boga dalam menyiapkan lulusan yang memiliki jiwa mandiri yang saat ini menjadi tantangan dalam pendidikan, yaitu antara lain: meningkatnya jumlah dan kualitas pendidikan kejuruan untuk memenuhi kebutuhan global dan lokal, dan menghasilkan tenaga kerja yang kreatif. Tujuan yang menarik adalah 70% lulusan SMK dapat bekerja setiap tahun. Hal ini memerlukan perlakuan. fasilitas, dukungan, dan upaya-upaya untuk mencapai kewirausahaan untuk mencapai kualitas lulusan sekolah kejuruan sesuai dengan kebutuhan dunia kerja. Progrm ini harus didisain berdasarkan kurikulum yang didisain dan dikembangkan kebutuhan stakeholders. Kelas kewirausahaan menerapkan kurikulum terintegrasi ke dalam mata pelajaran produktif. Dalam kelas kewirausahaan diharapkan dapat lebih efektif dalam menumbuhkan jiwa kewirausahaan dan kemandirian sehingga lulusan akan lebih memiliki jiwa yang bebas di dalam setiap situasi. THE ROLES OF ENTERPRENEURSHIP CLASS FOR VOCATIONAL HIGH SCHOOL OF TOURISMAbstractThis study aimed to determine the role of the entrepreneurial class in cultivating the entrepreneurial spirit, values and skills of SMK culinary student, to prepare graduates who have the spirit of independence as a responde to the current challenges including quantity and quality of vocational education to meet local, national, and global needs. The interesting objective is that about 70% of graduates shold be employed. In addition SMK generally provides entrepreneurship training in services. It need treatment, facilitatation, and encouragement of learners in order to become independence, responsible, creative, innovative, sporty, and entrepreneurship efforts to achieve the quality of vocational education graduates that meet the need of work place. Entrepreneurial class implements integrated subjects of vocational entrepreneurship. The entrepreneurial class is expected to be more effective in growing entrepreneurship spirit and independence of the prospective graduates of culinary tourism program.
Re-orientasi keterampilan kerja lulusan pendidikan kejuruan
Authors: Hanafi Ivan 
Published: October 2018

Pendidikan kejuruan diyakini memiliki konstribusi yang besar bagi perkembangan masyarakat dan peningkatan ekonomi suatu negara. Daya saing negara bergantung banyak pada tenaga kerja yang memilik pengetahuan dan keterampilan, karena mereka akan meningkatkan efisiensi dan nilai tambah produksi. Pendidikan dan latihan kejuruan pada hakekat adalah sebagai tempat untuk menyiapkan tenaga kerja berpengetahuan, berketerampilan, dan berkepribadian bagi memenuhi harapan dunia kerja dan industri. Tetapi kondisi riil menunjukkan banyak lulusan pendidikan kejuruan yang tidak memperoleh kerja, bahkan mereka yang telah bekerjapun menghadapi masalah keterampilan. Bekal pengetahuan dan keterampilan yang mereka miliki tidak cukup untuk dapat sustain dalam lingkungan kerja. Hal itu salah satunya disebabkan karena tenaga kerja tidak memiliki employability skills yang cukup seperti permintaan dunia kerja. Untuk itu, lembaga pendidikan kejuruan diharapkan mengantisipasi dengan tepat perkembangan yang terjadi di dunia kerja melalui berbagai pendekatan pembelajaran agar lebih fleksibel untuk merespon permintaan dunia kerja yang berubah dengan cepat. RE-ORIENTATION OF SKILLS OF VOCATIONAL EDUCATION GRADUATESAbstractSkills Re-orientation for Vocational School Graduates. It is believed that vocational education makes particular contribution on Indonesian concerning economics development. A competitiveness of the nation depends on quality of human resource in term of knowledge, skills, attitude. Vocational education and training basically is provided for preparing youth to have knowledge, skills, and characteristics to meet the requirements of work place. However, in fact Vocational High School leavers are unemployed, and the employed even face skills problems. Their knowledges, skills, and attitudes are under standard of work place requirements and incapable of sustaining hie/her current position in the work place. One of the reasons is because they don’t have enough employability skills to fulfil work place requirements. Therefore, vocational training institutions are required to anticipate firmly to developing the work place by employing learning strategies in order to have flexibilty due to a rapid changing of work place requirements.
Kesiapan berwirausaha pada siswa SMK kompetensi keahlian jasa boga
Authors: Sari Anggri Sekar 
Published: October 2018

Tujuan penelitian untuk mengungkapkan pengaruh peranan orangtua, ketrampilan pengelolaan UJB, dan self-efficacy terhadap kesiapan berwirausaha. Penelitian menggunakan pendekatan ex post facto. Populasi adalah siswa SMK Kompetensi Keahlian Jasa Boga di DIY. Sampel sebanyak 198 responden ditentukan menggunakan teknik proportional random sampling. Data dikumpulkan dengan instrumen angket dan tes. Analisis data menggunakan statistik deskriptif dan regresi linier berganda. Penelitian menunjukkan kesiapan berwirausaha relatif sedang (30,8%). Uji hipotesis menemukan bahwa variabel peranan orangtua berpengaruh positif dan signifikan terhadap kesiapan berwirausaha sebesar 0,374 (sig 0,000). Begitu pula ketrampilan pengelolaan UJB sebesar 0,256 (sig 0,000) dan self-efficacy sebesar 0,191 (sig 0,007) berpengaruh positif dan signifikan terhadap kesiapan berwirausaha. Terdapat pengaruh secara bersama-sama antara peranan orangtua, ketrampilan pengelolaan UJB, dan self efficacy sebesar 55% terhadap kesiapan berwirausaha. THE ENTREPRENEURIAL READINESS OF THE STUDENTS OF THE FOOD & BEVERAGE SKILL COMPETENCY IN PUBLIC VOCATIONAL HIGH SCHOOLSAbstractThe purposes of this research are to reveal the effect of parents` roles, vocational skills in the Food & Beverage Business Management, and self-efficacy on the entrepreneurial readiness. This study uses the ex post facto approach. The population is the students of the food & beverage skill competency in public vocational high schools in Yogyakarta Spesial Territory. A sample of 198 respondents is established using the proportional random sampling technique. The data are collected using questionnaires and a test. The data are analyzed using descriptive statistics and using multiple linear regression. The results show that almost half (30.8) of students have a low entrepreneurial readiness. The hypothesis testing shows that the parents` roles have a positive and significant effect on the entrepreneurial readiness as much as 0.374 (sig 0.000). Similarly, vocational skills in the Food & Beverage Business Management and self-efficacy have significant and positive effects on the entrepreneurial readiness as much as 0.256 (sig 0.000) and as much as 0.191 (sig 0.007) respectively The of parents` roles, vocational skills in the Food & Beverage Business Management, and self-efficacy collectively have the effect of 55 percent on the entrepreneurial readiness.
Faktor-faktor yang mempengaruhi kinerja guru sekolah menengah kejuruan
Authors: Susanto Hary 
Published: October 2018

Penelitian ini bertujuan untuk mengungkapkan: (1) pengaruh kompetensi guru dan kepemimpinan kepala sekolah terhadap motivasi kerja guru SMK di Kabupaten Hulu Sungai Selatan, Kalimantan Selatan, baik secara sendiri-sendiri maupun bersama-sama, (2) pengaruh kompetensi guru, kepemimpinan kepala sekolah, dan motivasi kerja guru terhadap kinerja guru SMK di Kabupaten Hulu Sungai Selatan, Kalimantan Selatan, baik secara sendiri-sendiri maupun bersama-sama, dan secara langsung atau tidak langsung. Hasil penelitian menunjukkan bahwa terdapat pengaruh positif dan signifikan: (1) kompetensi guru dan kepemimpinan kepala sekolah terhadap motivasi kerja guru SMK di Kabupaten Hulu Sungai Selatan, Kalimantan Selatan, baik secara sendiri-sendiri maupun bersama-sama dengan taraf signifikansi 0,038; 0,045; dan 0,001. (2) kompetensi guru, kepemimpinan kepala sekolah, dan motivasi kerja guru terhadap kinerja guru SMK di Kabupaten Hulu Sungai Selatan, Kalimantan Selatan, baik secara sendiri-sendiri maupun bersama-sama, dan secara langsung atau tidak langsung taraf signifikansi 0,036; 0.003; 0,036; 0,000; (0,038 dan 0,036); (0,045 dan 0,036). THE FACTORS OF AFFECTING THE PERFORMANCE OF THE TEACHERS’ OF STATE VOCATIONAL HIGH SCHOOLAbstractThis study aims to search for the magnitude of, the effect of: (1) the teachers’competence and headmasters’ leadership on teachers’work motivation, individually and simultaneously; (2) the effect of the teachers’competence, headmasters’ leadership and teachers’work motivation on teachers’ performance, individually and simultaneously, and directly and indirectly. The result of the study shows that there is a positive and significant effect of: (1) the teachers’competence and headmasters’ leadership on teachers’work motivation, individually and simultaneously with the significance level of 0.038; 0.045; and 0.001. (2) the effect of the teachers’competence, headmasters’ leadership and teachers’work motivation on teachers’ performance, individually and simultaneously, and directly and indirectly with the significance level of 0.036; 0.003; 0.000; (0.038 and 0.036); (0.045 and 0.036).
Keterampilan TIK guru produktif SMK di Kabupaten Hulu Sungai Utara dan implementasinya dalam pembelajaran
Authors: Fitriyadi Herry 
Published: October 2018

Guru sebagai aktor utama dalam proses pendidikan dituntut harus dengan cepat memperbaharui pengetahuan, keterampilan, dan kompetensinya dalam bidang Teknologi Informasi dan Komunikasi (TIK), tak terkecuali guru produktif Sekolah Menengah Kejuruan (SMK), dalam realitas masih minimnya implementasi TIK dalam pembelajaran dan adanya kendala internal dan eksternal SMK dalam pelaksanaan program TIK. Berdasarkan hal-hal tersebut, penelitian ini dilakukan untuk menginvestigasi penguasaan keterampilan TIK guru produktif SMK dan implementasi TIK dalam pembelajaran produktif SMK, serta mengidentifikasi kendala-kendala yang menjadi penghambat implementasi TIK dalam pembelajaran produktif SMK di Kabupaten Hulu Sungai Utara Provinsi Kalimantan Selatan. Kesimpulan hasil penelitian ini sebagai berikut: 1) Keterampilan TIK guru produktif SMK secara keseluruhan termasuk dalam kategori rendah. 2) Implementasi TIK dalam pembelajaran produktif SMK secara keseluruhan termasuk dalam kategori menengah. 3) Kendala-kendala implementasi TIK dalam pembelajaran produktif SMK berkaitan dengan kebijakan pemerintah daerah, pendanaan program, pengembangan profesional di bidang TIK, ketersediaan sumber daya TIK, dan penggunaan TIK di sekolah. THE ICT SKILLS OF PRODUCTIVE TEACHERS IN VHS IN THE REGENCY OF HULU SUNGAI UTARA AND THE IMPLEMENTATION IN TEACHINGAbstractThe teachers as the main actors in the process of education is required to quickly renew their knowledge, skills and competence in the field of Information and Communicaton Technology (ICT), no exception vocational high schools (VHS) productive teachers’, in reality the lack of implementation of ICT in learning, and the internal and external constraints in the implementation of ICT in VHS. Based on these things, this study was conducted to investigate the ICT skill mastery of productive teachers in VHS and the ICT implementation in the productive teaching in VHS, and to identify the constraints that inhibit theICT implementation in productive teaching in VHS in the Regency of HSU, the Province of South Kalimantan. The conclusions of the study are as follows. 1) The VHS productive teachers’ ICT skills in general are in the low category. 2) The ICT implementation in productive teaching in VHS in general is in the moderate category. 3) The constraints in the ICT implementation in productive teaching in VHS are related to the local government’s policies, program funding, professional development in ICT, availability of ICT resources, and ICT utilization in schools.