bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrocatalytic Biosynthesis using a Bucky Paper Functionalized by [Cp*Rh(bpy)Cl]+ and a Renewable Enzymatic Layer
Authors: Zhang Lin , Etienne Mathieu , Vilà Neus , Le Thi Xuan Huong , Kohring Gert‐Wieland , Walcarius Alain 
Published: June 2018

AbstractA bioelectrode for electroenzymatic synthesis was prepared, combining a layer for NADH regeneration and a renewable layer for enzymatic substrate reduction. The covalent immobilization of a rhodium complex mediator ([Cp*Rh(bpy)Cl]+) on the surface of a bucky paper electrode was achieved by following an original protocol in two steps. A bipyridine ligand was first grafted on the electrode by electro‐reduction of bipyridyl diazonium cations generated from 4‐amino‐2,2′‐bipyridine, and the complex was then formed by reaction with [RhCp*Cl2]2. A turnover frequency of 1.3 s−1 was estimated for the electrocatalytic regeneration of NADH by this immobilized complex, with a Faraday efficiency of 83 %. The bucky paper electrode was then overcoated by a bio‐doped porous layer made of glassy fibers with immobilized D‐sorbitol dehydrogenase. This assembly allowed for the efficient separation of the enzyme and the rhodium catalyst, which is a prerequisite for effective bioelectrocatalysis with such bioelectrochemical system, while allowing effective mass transport of NAD+/NADH cofactor from one layer to the other. Thereby, it was possible to reuse the same mediator‐functionalized bucky paper with three different enzyme layers. The bioelectrode was applied to the electroenzymatic reduction of D‐fructose to D‐sorbitol. A turnover frequency of 0.19 s−1 for the rhodium complex was observed in the presence of 3 mM D‐fructose and a total turnover number higher than 12000 was estimated.
Highly Efficient and Selective Visible‐Light Driven CO2‐to‐CO Conversion by a Co(II) Homogeneous Catalyst in H2O/CH3CN Solution
Authors: Liu Dong‐Cheng , Huang Hai‐Hua , Wang Jia‐Wei , Jiang Long , Zhong Di‐Chang , Lu Tong‐Bu 
Published: June 2018

AbstractThe photochemical reduction of CO2 to chemical resources has displayed the promise to solve energy and environmental problems. To facilitate this reaction, a considerable challenge is to design not only highly efficient and selective, but also economic catalysts. In this study, we report a homogeneous catalyst, [CoL1(CH3CN)](ClO4)2 (1, L1=Tris[2‐(iso‐propylamino)ethyl]amine) which displays high activity and selectivity for CO2 reduction to CO driven by visible light in a water‐containing system, with turnover numbers (TONCO) and turnover frequencies (TOF), and CO selectivity values of 44800, 1.24 s−1 and 97 %, respectively. The excellent performances of 1 for the photocatalytic CO2‐to‐CO conversion is confirmed by control experiments and its catalytic mechanism is corroborated by DFT calculations.
Accelerated Ru–Cu Trinuclear Cooperative C−H Bond Functionalization of Carbazoles: A Kinetic and Computational Investigation
Authors: Jones Alexander W. , Rank Christian K. , Becker Yanik , Malchau Christian , Funes‐Ardoiz Ignacio , Maseras Feliu , Patureau Frederic W. 
Published: June 2018

AbstractThe mechanism of a trinuclear cooperative dehydrogenative C−N bond‐forming reaction is investigated in this work, which avoids the use of chelate‐assisting directing groups. Two new highly efficient Ru/Cu co‐catalyzed systems were identified, allowing orders of magnitude greater TOFs than the previous state of the art. In‐depth kinetic studies were performed in combination with advanced DFT calculations, which reveal a decisive rate‐determining trinuclear Ru–Cu cooperative reductive elimination step (CRE).
Computational Methods for Predicting Protein‐Protein Interactions Using Various Protein Features
Authors: Ding Ziyun , Kihara Daisuke 
Published: June 2018

AbstractUnderstanding protein‐protein interactions (PPIs) in a cell is essential for learning protein functions, pathways, and mechanism of diseases. PPIs are also important targets for developing drugs. Experimental methods, both small‐scale and large‐scale, have identified PPIs in several model organisms. However, results cover only a part of PPIs of organisms; moreover, there are many organisms whose PPIs have not yet been investigated. To complement experimental methods, many computational methods have been developed that predict PPIs from various characteristics of proteins. Here we provide an overview of literature reports to classify computational PPI prediction methods that consider different features of proteins, including protein sequence, genomes, protein structure, function, PPI network topology, and those which integrate multiple methods. © 2018 by John Wiley & Sons, Inc.
A low‐power technique for high‐resolution dynamic comparators
Authors: Khorami Ata , Sharifkhani Mohammad 
Published: June 2018

SummaryA low‐power technique for high‐resolution comparators is introduced. In this technique, p‐type metal‐oxide‐semiconductor field‐effect transistors are employed as the input of the latch of the comparator just like the input of the preamplifier. The latch and preamplifier stages are activated in a special pattern using an inverter‐based controller. Unlike the conventional comparator, the preamplification delay can be set to an optimum low value even if after the preamplification, the output voltages is less than n‐channel metal‐oxide semiconductor voltage threshold. As a result, the proposed comparator reduces the power consumption significantly and enhances the speed. The speed and power benefits of the proposed comparator were verified using analytical derivations, PVT corners, and post layout simulations. The results confirm that the introduced technique reduces the power consumption by 60%, also, provides 57% better comparison speed for an input common mode voltage (Vcm) range of 0‐Vdd/2.
Association between walnut consumption and diabetes risk in NHANES
Authors: Arab Lenore , Dhaliwal Satvinder K. , Martin Carly J. , Larios Alena D. , Jackson Nicholas J. , Elashoff David 
Published: June 2018

AbstractBackgroundDietary interventions and cohort studies relating tree nut consumption to blood glucose levels suggest a possible effect of walnuts.ObjectiveTo examine the associations between walnut consumption and diabetes risk using data from the National Health and Nutrition Examination Survey.MethodsNational Health and Nutrition Examination Survey data on adults conducting 24‐hour dietary recall was pooled across the years 1999 through 2014. Diabetes status or risk was based on self‐report, medication use, fasting plasma glucose levels, and haemoglobin A1c (HbA1c) levels. Individuals were characterized based on reported consumption of walnuts, mixed‐nuts, or no nuts.ResultsAfter adjustment for covariates, walnut consumers showed lower risk for diabetes compared with non‐nut consumers based on self‐report (odds ratio of 0.47, 95% confidence interval [CI] 0.31‐0.72) as well as fasting blood glucose (relative risk ratio 0.32, CI 0.17‐0.58) and HbA1c (relative risk ratio 0.51, CI 0.27‐0.99). For each standard deviation of increase in walnut intake, prevalence of diabetes dropped 47%. The gender by walnut interaction suggests that the effect may be more potent among women than men (dose response P = .061).ConclusionsBoth among individuals with known diabetes and those diagnosed based on elevated diabetes blood markers, the prevalence of individuals with diabetes was significantly lower among the walnut consumers. A possible gender‐specific effect invites further attention.
A geostatistical state‐space model of animal densities for stream networks
Authors: Hocking Daniel J. , Thorson James T. , O'Neil Kyle , Letcher Benjamin H. 
Published: June 2018

AbstractPopulation dynamics are often correlated in space and time due to correlations in environmental drivers as well as synchrony induced by individual dispersal. Many statistical analyses of populations ignore potential autocorrelations and assume that survey methods (distance and time between samples) eliminate these correlations, allowing samples to be treated independently. If these assumptions are incorrect, results and therefore inference may be biased and uncertainty underestimated. We developed a novel statistical method to account for spatiotemporal correlations within dendritic stream networks, while accounting for imperfect detection in the surveys. Through simulations, we found this model decreased predictive error relative to standard statistical methods when data were spatially correlated based on stream distance and performed similarly when data were not correlated. We found that increasing the number of years surveyed substantially improved the model accuracy when estimating spatial and temporal correlation coefficients, especially from 10 to 15 yr. Increasing the number of survey sites within the network improved the performance of the nonspatial model but only marginally improved the density estimates in the spatiotemporal model. We applied this model to brook trout data from the West Susquehanna Watershed in Pennsylvania collected over 34 yr from 1981 to 2014. We found the model including temporal and spatiotemporal autocorrelation best described young of the year (YOY) and adult density patterns. YOY densities were positively related to forest cover and negatively related to spring temperatures with low temporal autocorrelation and moderately high spatiotemporal correlation. Adult densities were less strongly affected by climatic conditions and less temporally variable than YOY but with similar spatiotemporal correlation and higher temporal autocorrelation.
A systematic review of mHealth interventions for the support of eating disorders
Authors: Anastasiadou Dimitra , Folkvord Frans , Lupiañez‐Villanueva Francisco 
Published: June 2018

AbstractObjectiveTo systematically review the existing evidence of mobile health (mHealth) tools for the treatment of eating disorders (ED).MethodElectronic databases (Pubmed, PsycInfo, and SCOPUS) were searched, and PRISMA guidelines were followed. Selected studies were divided into three categories according to the intended purpose of the mHealth tools used: (a) sole means of support, (b) complementary to standard face‐to‐face treatment, and (c) for relapse prevention. Additionally, studies were assessed on efficacy, qualitative information, and methodological quality.ResultsFifteen studies were identified. Most studies using mHealth as a sole means of intervention or adjunct to traditional therapy showed no effects, although an improvement at postassessment was present in vodcast, smartphone application, and text‐messaging interventions. Between group effects were only found for a text‐messaging intervention for relapse prevention. Qualitative analyses showed that most mHealth interventions were considered as acceptable, supporting, and motivating by patients and therapists, although different important problems were observed in individual studies.ConclusionsLimited effects were found for mHealth interventions to reduce ED‐related symptoms. A common evaluation framework for ED mHealth interventions should be proposed to assess the validity of interventions before implementing them on a larger scale in clinical practice.
Differences in cancer gene copy number alterations between Epstein‐Barr virus‐positive and Epstein‐Barr virus‐negative nasopharyngeal carcinoma
Authors: Ooft Marc Lucas , van Ipenburg Jolique , van de Loo Rob J. M. , de Jong Rick , Moelans Cathy B. , de Bree Remco , de Herdt Martine J. , Koljenović Senada , de Jong R. Baatenburg , Hardillo J. , Willems Stefan Martin 
Published: June 2018

AbstractBackgroundNasopharyngeal carcinoma (NPC) treatment is mainly based on clinical staging. We hypothesize that better understanding of the molecular heterogeneity of NPC can aid in better treatment decisions. Therefore, the purpose of this study was to present our exploration of cancer gene copy‐number alterations (CNAs) of Epstein‐Barr virus (EBV)‐positive and EBV‐negative NPC.MethodsMultiplex ligation‐dependent probe amplification was applied to detect CNAs of 36 cancer genes (n = 103). Correlation between CNAs, clinicopathological features, and survival were examined.ResultsThe CNAs occurred significantly more in EBV‐negative NPC, with PIK3CA and MCCC1 (P < .001) gain/amplification occurring more frequently. Gain/amplification of cyclin‐L1 (CCNL1) and PTK2 (P < .001) predict worse disease‐free survival (DFS) in EBV‐positive NPC.ConclusionThe EBV‐positive and EBV‐negative NPC show some similarities in cancer gene CNAs suggesting a common pathogenic route but also important differences possibly indicating divergence in oncogenesis. Copy number gain/amplification of CCNL1 and PTK2 are possibly good predictors of survival in EBV‐positive NPC.
Developing Multimodal Literacy Through Teaching the Critical Viewing of Films in Singapore
Authors: Lim Victor Fei , Tan Serene Kok Yin 
Published: June 2018

AbstractThe changing nature of communication has accentuated the need to develop multimodal literacy in students. Although the conventional way of asking a series of questions to elicit students’ comprehension has helped build reading and comprehension skills, teachers could provide more support in the form of the language, pedagogical scaffolds, and technological tools to develop students’ critical viewing of multimodal texts. Working with teachers from a secondary school in Singapore, researchers from the Ministry of Education in Singapore trialed an instructional approach to teach the critical viewing of films. The approach is informed by systemic functional theory, multimodality, and media studies. The authors describe the instructional approach and the study conducted to develop multimodal literacy in adolescent students.
Parathyroid hormone for bone regeneration
Authors: Wojda Samantha J. , Donahue Seth W. 
Published: June 2018

ABSTRACTDelayed healing and/or non‐union occur in approximately 5–10% of the fractures that occur annually in the United States. Segmental bone loss increases the probability of non‐union. Though grafting can be an effective treatment for segmental bone loss, autografting is limited for large defects since a limited amount of bone is available for harvest. Parathyroid hormone (PTH) is a key regulator of calcium homeostasis in the body and plays an important role in bone metabolism. Presently PTH is FDA approved for use as an anabolic treatment for osteoporosis. The anabolic effect PTH has on bone has led to research on its use for bone regeneration applications. Numerous studies in animal models have indicated enhanced fracture healing as a result of once daily injections of PTH. Similarly, in a human case study, non‐union persisted despite treatment attempts with internal fixation, external fixation, and autograft in combination with BMP‐7, until off label use of PTH1‐84 was utilized. Use of a biomaterial scaffold to locally deliver PTH to a defect site has also been shown to improve bone formation and healing around dental implants in dogs and drill defects in sheep. Thus, PTH may be used to promote bone regeneration and provide an alternative to autograft and BMP for the treatment of large segmental defects and non‐unions. This review briefly summarizes the unmet clinical need for improved bone regeneration techniques and how PTH may help fill that void by both systemically and locally delivered PTH for bone regeneration applications. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2586–2594, 2018.
Peri‐implantitis
Authors: Schwarz Frank , Derks Jan , Monje Alberto , Wang Hom‐Lay 
Published: June 2018

AbstractObjectivesThis narrative review provides an evidence‐based overview on peri‐implantitis for the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions.MethodsA literature review was conducted addressing the following topics: 1) definition of peri‐implantitis; 2) conversion from peri‐implant mucositis to peri‐implantitis, 3) onset and pattern of disease progression, 4) characteristics of peri‐implantitis, 5) risk factors/indicators for peri‐implantitis, and 6) progressive crestal bone loss in the absence of soft tissue inflammation.Conclusions
Peri‐implantitis is a pathological condition occurring in tissues around dental implants, characterized by inflammation in the peri‐implant connective tissue and progressive loss of supporting bone.
The histopathologic and clinical conditions leading to the conversion from peri‐implant mucositis to peri‐implantitis are not completely understood.
The onset of peri‐implantitis may occur early during follow‐up and the disease progresses in a non‐linear and accelerating pattern.
Peri‐implantitis sites exhibit clinical signs of inflammation and increased probing depths compared to baseline measurements.
At the histologic level, compared to periodontitis sites, peri‐implantitis sites often have larger inflammatory lesions.
Surgical entry at peri‐implantitis sites often reveals a circumferential pattern of bone loss.
There is strong evidence that there is an increased risk of developing peri‐implantitis in patients who have a history of chronic periodontitis, poor plaque control skills, and no regular maintenance care after implant therapy. Data identifying “smoking” and “diabetes” as potential risk factors/indicators for peri‐implantitis are inconclusive.
There is some limited evidence linking peri‐implantitis to other factors such as: post‐restorative presence of submucosal cement, lack of peri‐implant keratinized mucosa and positioning of implants that make it difficult to perform oral hygiene and maintenance.
Evidence suggests that progressive crestal bone loss around implants in the absence of clinical signs of soft tissue inflammation is a rare event.
Mucogingival conditions in the natural dentition: Narrative review, case definitions, and diagnostic considerations
Authors: Cortellini Pierpaolo , Bissada Nabil F. 
Published: June 2018

AbstractBackgroundMucogingival deformities, and gingival recession in particular, are a group of conditions that affect a large number of patients. Since life expectancy is rising and people are retaining more teeth both gingival recession and the related damages to the root surface are likely to become more frequent. It is therefore important to define anatomic/morphologic characteristics of mucogingival lesions and other predisposing conditions or treatments that are likely to be associated with occurrence of gingival recession.ObjectivesMucogingival defects including gingival recession occur frequently in adults, have a tendency to increase with age, and occur in populations with both high and low standards of oral hygiene. The root surface exposure is frequently associated with impaired esthetics, dentinal hypersensitivity and carious and non‐carious cervical lesions. The objectives of this review are as follows (1) to propose a clinically oriented classification of the main mucogingival conditions, recession in particular; (2) to define the impact of these conditions in the areas of esthetics, dentin hypersensitivity and root surface alterations at the cervical area; and (3) to discuss the impact of the clinical signs and symptoms associated with the development of gingival recessions on future periodontal health status.ResultsAn extensive literature search revealed the following findings: 1) periodontal health can be maintained in most patients with optimal home care; 2) thin periodontal biotypes are at greater risk for developing gingival recession; 3) inadequate oral hygiene, orthodontic treatment, and cervical restorations might increase the risk for the development of gingival recession; 4) in the absence of pathosis, monitoring specific sites seems to be the proper approach; 5) surgical intervention, either to change the biotype and/or to cover roots, might be indicated when the risk for the development or progression of pathosis and associated root damages is increased and to satisfy the esthetic requirements of the patients.ConclusionsThe clinical impact and the prevalence of conditions like root surface lesions, hypersensitivity, and patient esthetic concern associated with gingival recessions indicate the need to modify the 1999 classification. The new classification includes additional information, such as recession severity, dimension of the gingiva (gingival biotype), presence/absence of caries and non‐carious cervical lesions, esthetic concern of the patient, and presence/absence of dentin hypersensitivity.
Plaque‐induced gingivitis: Case definition and diagnostic considerations
Authors: Trombelli Leonardo , Farina Roberto , Silva Cléverson O. , Tatakis Dimitris N. 
Published: June 2018

AbstractObjectiveClinical gingival inflammation is a well‐defined site‐specific condition for which several measurement systems have been proposed and validated, and epidemiological studies consistently indicate its high prevalence globally. However, it is clear that defining and grading a gingival inflammatory condition at a site level (i.e. a “gingivitis site”) is completely different from defining and grading a “gingivitis case” (GC) (i.e. a patient affected by gingivitis), and that a “gingivitis site” does not necessarily mean a “GC”. The purpose of the present review is to summarize the evidence on clinical, biochemical, microbiologic, genetic markers as well as symptoms associated with plaque‐induced gingivitis and to propose a set of criteria to define GC.ImportanceA universally accepted case definition for gingivitis would provide the necessary information to enable oral health professionals to assess the effectiveness of their prevention strategies and treatment regimens; help set priorities for therapeutic actions/programs by health care providers; and undertake surveillance.FindingsBased on available methods to assess gingival inflammation, GC could be simply, objectively and accurately identified and graded using bleeding on probing score (BOP%)ConclusionsA patient with intact periodontium would be diagnosed as a GC according to a BOP score ≥ 10%, further classified as localized (BOP score ≥ 10% and ≤30%) or generalized (BOP score > 30%). The proposed classification may also apply to patients with a reduced periodontium, where a GC would characterize a patient with attachment loss and BOP score ≥ 10%, but without BOP in any site probing ≥4 mm in depth.
New Interfacial Rheology Characteristics Measured using a Spinning‐Drop Rheometer at the Optimum Formulation of a Simple Surfactant–Oil–Water System
Authors: Marquez Ronald , Forgiarini Ana M. , Fernández Jesús , Langevin Dominique , Salager Jean‐Louis 
Published: June 2018

AbstractA new spinning‐drop tensiometer with an oscillating rotation velocity was used to measure the interfacial rheological properties of systems with very low interfacial tensions in the zone close to the so‐called optimum formulation of surfactant–oil–water systems. 2 simple formulation scans were selected: One with an extended anionic surfactant using a salinity variation in the water phase, and another with a mixture of 2 nonionic surfactants in a scan produced by changing their proportion. With both systems it was corroborated that at optimum formulation (i.e., at hydrophilic–lipophilic deviation (HLD) = 0), both the interfacial tension and the emulsion stability exhibit a deep minimum. A clear relationship was also found between the phase behavior and the interfacial rheological properties (dilational elasticity and viscosity). For the very first time and in both kinds of scans (salinity or average ethylene oxide number), it was found that the interfacial elastic modulusEand the interfacial viscosity, as well as the phase angle also exhibit a minimum at optimum formulation. These groundbreaking findings could be applied to emulsion instability at optimum formulation and to its applications in emulsion breaking.