bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the effect of clinical history before electrocardiogram interpretation on the visual behavior and interpretation accuracy of clinicians
Authors: Davies Alan , Harper Simon , Vigo Markel , Jay Caroline 
Published: August 2019

AbstractWe examine the impact of the presentation of a patient’s clinical history on subsequent visual appraisal and interpretation accuracy of electrocardiograms (ECGs). Healthcare-practitioners (N = 31) skilled in 12-lead ECG interpretation took part in a repeated-measures experiment with counterbalancing viewing 9 ECGs on a computer screen in two separate conditions: with/without an associated patient-history. A Hellinger-distance calculation was applied using a permutation test to eye-movement transitions at two granularity levels: between the ECG leads, and between smaller grid-cells, whose size was determined via data-driven clustering of the fixation points. Findings indicate that presentation of clinical-history does affect accuracy of interpretation in one ECG. Visual-behavior differed as a function of both history presentation and accuracy when considering transitions between the data-driven grid units (using a fine granularity, and able to show attention to parts of the waveform). Differences in visual-behavior at waveform level demonstrate an influence of patient-history and expertise that are not detected at the lead level. Visual-behaviour differs according to whether a patient-history is presented, and whether a clinician provides an accurate interpretation. This difference is evident in how the waveform itself is viewed, and is less present at the coarse granularity of visual transitions between leads. To understand how clinicians interpret ECGs, and potentially other medical images, visual transitions should be considered at a fine level of granularity, determined in a data-driven fashion.
Heterogeneity in fetal growth velocity
Authors: Sato Noriko , Miyasaka Naoyuki 
Published: August 2019

AbstractFetal growth quality is associated with susceptibility to non-communicable diseases. Fetal size has been conventionally assessed using the averaged growth chart, but fetal growth velocity has recently been attracting attention as another important aspect of fetal development. Since fetal growth velocity may reflect fetal response to various conditions during the developmental process within the maternal constraint, it is reasonable to imagine that there might exist a physiological diversity in growth velocity patterns over time, which has never been explored. We conducted a retrospective cohort study designed to evaluate the heterogeneity of fetal growth velocity in singleton pregnancies in the Japanese population. We leveraged the high frequency of prenatal checkup to collect large numbers of ultrasound measurements of every fetus (N = 801) and computationally analyzed individual changes in growth per week. Latent class trajectory analysis identified three distinct velocity patterns. The variation in growth velocity appeared in the third trimester and corresponded to the differences in neonatal size. This heterogeneity was not simply explained by maternal factors and fetal sex, although those factors had time-varying effects on fetal size. Our findings regarding the heterogeneity in fetal growth velocity will aid in the comprehensive understanding of fetal development quality.
Comparison of light-induced formation of reactive oxygen species and the membrane destruction of two mesoporphyrin derivatives in liposomes
Authors: Bőcskei-Antal Barnabás , Zolcsák Ádám , Kósa Nikoletta , Voszka István , Csík Gabriella , Tóth Katalin , Herenyi Levente 
Published: August 2019

AbstractThe photodynamic effect requires the simultaneous presence of light, photosensitizer (PS) and molecular oxygen. In this process, the photoinduced damage of cells is caused by reactive oxygen species (ROS). Besides DNA, the other target of ROS is the membranes, separating internal compartments in living cells. Hence, the ability of ROS formation of porphyrins as PSs, in liposomes as simple models of cellular membranes is of outstanding interest. Earlier we compared the binding parameters and locations of mesoporphyrin IX dihydrochloride (MPCl) and mesoporphyrin IX dimethyl ester (MPE), in small unilamellar vesicles (SUV) made from various saturated phosphatidylcholines. In this study, we used the same kinds of samples for comparing the ROS forming ability. Triiodide production from potassium iodide because of light-induced ROS in the presence of molybdate catalyst was applied, and the amount of product was quantitatively followed by optical spectrometry. Furthermore, we demonstrated and carefully studied SUVs disruption as direct evidence of membrane destruction by the methods of dynamic light scattering (DLS) and fluorescence correlation spectroscopy (FCS), applying unsaturated phosphatidylcholines as membrane components. Although the ROS forming ability is more pronounced in the case of MPCl, we found that the measured disruption was more effective in the samples containing MPE.
Distribution and ecological risk assessment of PEDCs in the water, sediment and Carex cinerascens of Poyang Lake wetland, China
Authors: Yang Pinghua 
Published: August 2019

AbstractPhenolic endocrine disrupting chemicals (PEDCs), such as 4-nonylphenol (NP), 4-t-octylphenol (OP), bisphenol A (BPA), and nonylphenol-di-ethoxylate (NP2EO), can cause feminization and carcinogenesis. This study assessed the distributions of NP, OP, BPA, and NP2EO in the water, sediment, and Carex cinerascens of Poyang Lake wetland. The four PEDCs were ubiquitous. The concentrations of NP and OP in the water and sediment of the wetland were significantly lower than those in other regions of China. Average BPA concentrations in the water, sediment, and Carex cinerascens samples were 40.49 ± 18.42 ng/L, 9.840 ± 3.149 ng/g, and 3.25 ± 1.40 ng/g, respectively; the BPA concentration in the water was similar to that of other rivers in China. Average NP2EO concentrations in the wetland were 3125.9 ± 478.1 ng/L, 650.0 ± 209.9 ng/g, and 275.8 ± 59.0 ng/g in the water, sediment, and Carex cinerascens samples, respectively. The predicted no-effect concentrations in sediment for NP, OP, BPA, and NP2EO were estimated to be 75.41, 45.25, 8.22, and 237.5 ng/g, respectively. The risk quotient (RQ) method was used to characterise the ecological risk from these PEDCs. A high ecological risk (RQ ≥ 1) from BPA was observed for 0%, 57.69%, and 5.00% of water, sediment, and C. cinerascens samples, respectively, while a high risk from NP2EO was observed for 71.43%, 96.15%, and 55.00% of samples. Ecological risk varied spatially. The high ecological risk from NP2EO in Poyang Lake wetland may be a result of non-point pollution from rural areas and sewage from Poyang Lake basin.
Iron-rich Smectite Formation in Subseafloor Basaltic Lava in Aged Oceanic Crust
Authors: Yamashita Seiya , Mukai Hiroki , Tomioka Naotaka , Kagi Hiroyuki , Suzuki Yohey 
Published: August 2019

AbstractBasalt weathering in oceanic crust controls long-term elemental cycling on Earth. It is unknown whether basalt weathering tends to continue in unsedimented oceanic crust with formation ages of >10–20 million years (Ma), when fluid circulation is restricted by the formation of secondary minerals in fractures/veins. We investigated basalt weathering in 13.5-, 33.5- and 104-Ma oceanic crust below the South Pacific Gyre by combining bulk and in-situ clay mineral characterisations. Here we show the formation of iron-rich smectite at the rims of fractures/veins in 33.5-Ma and 104-Ma core samples from depths as great as 121 metres below the seafloor. In contrast, iron-rich smectite formation was not observed in three 13.5-Ma core samples, which suggests that iron-rich smectite formation may be affected by the dilution of aqueous silica supplied from basalt dissolution by actively circulating fluid. As iron-rich smectite from the 33.5-Ma and 104-Ma core samples was more enriched in Mg and K than that typically found at hydrothermal mounds, iron-rich smectite formation appears to result from basalt weathering rather than hydrothermal alteration. Our results suggest that unsedimented basaltic basement is permeable and reactive to host microbial life in aged oceanic crust on Earth and possibly in the deep subsurface on Mars.
Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice
Authors: Jurado-Ruiz Enrique , Álvarez-Amor Leticia , Varela Lourdes M. , Berná Genoveva , Parra-Camacho María S. , Oliveras-Lopez María J. , Martínez-Force Enrique , Rojas Anabel , Hmadcha Abdelkrim , Soria Bernat , Martín Franz 
Published: August 2019

AbstractDietary composition plays an important role in the pathophysiology of type 2 diabetes. Monounsaturated fatty acid consumption has been positively associated with improved insulin sensitivity and β-cell function. We examined whether an extra virgin olive oil (EVOO) high fat diet (HFD) can improve glucose homeostasis. C57BL/6J mice were fed a standard diet or a lard-based HFD to induce type 2 diabetes. Then, HFD mice were fed with three different based HFD (lard, EVOO and EVOO rich in phenolic compounds) for 24 weeks. HFD-EVOO diets significantly improved glycemia, insulinemia, glucose tolerance, insulin sensitivity and insulin degradation. Moreover, EVOO diets reduced β-cell apoptosis, increased β-cell number and normalized islet glucose metabolism and glucose induced insulin secretion. No additional effects were observed by higher levels of phenolic compounds. Thus, EVOO intake regulated glucose homeostasis by improving insulin sensitivity and pancreatic β-cell function, in a type 2 diabetes HFD animal model.
Does miR-618 rs2682818 variant affect cancer susceptibility? Evidence from 10 case–control studies
Authors: Feng Xingliang , Ji Dan , Liang Chaozhao , Fan Song 
Published: August 2019

Abstract
Piles of evidence have supported the relationship between miR-618 rs2682818 polymorphism and tumorigenesis, but the conclusion remains inconsistent. In the present study, we conducted a meta-analysis to sniff out the potential risk between miR-618 rs2682818 and overall cancers. Crude odds ratios (ORs) and 95% confidence intervals (CIs) analyzed by Z-test were employed to estimate the potential interrelation in five genetic models. We also prospected how the rs2682818 affects the second structure of miR-618. Finally, 10 independent studies meet the enrolled criteria, along with 4099 cancer cases and 5057 healthy controls. Overall, no exceeding interrelation was sniffed out in the pooled data among five inherited models, as well as stratified analyses. Whereas, the enhanced cancer risk of miR-618 rs2682818 variant stratified by breast cancer was revealed, in heterozygote genetic model (AC vs. CC: OR = 1.291, 95%CI = 1.012–1.648, P = 0.040) and dominant contrast model (AA + AC vs. CC: OR = 1.280, 95%CI = 1.009–1.623, P = 0.042). The second structure prediction result shown that the mutant A allele might change the first stem-loop of miR-618, and the free energy of it would turn from –39.1 to –35.1 kcal/mol. All in all, our meta-analysis had successfully chased down that miR-618 rs2682818 polymorphism is not linked with overall cancer risk, but in the dominant genotype of breast cancer.
Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition
Authors: Yuan Yujia , Chen Younan , Peng Tianqing , Li Lan , Zhu Wuzheng , Liu Fei , Liu Shuyun , An Xingxing , Luo Ruixi , Cheng Jingqiu , Liu Jingping , Lu Yanrong 
Published: August 2019

Abstract
Macrophage polarization toward the M1 phenotype and its subsequent inflammatory response have been implicated in the progression of diabetic complications. Despite adverse consequences of autophagy impairment on macrophage inflammation, the regulation of macrophage autophagy under hyperglycemic conditions is incompletely understood. Here, we report that the autophagy–lysosome system and mitochondrial function are impaired in streptozotocin (STZ)-induced diabetic mice and high glucose (HG)-stimulated RAW 264.7 cells. Mitochondrial dysfunction promotes reactive oxygen species (ROS) production and blocks autophagic flux by impairing lysosome function in macrophages under hyperglycemic conditions. Conversely, inhibition of mitochondrial ROS by Mito-TEMPO prevents HG-induced M1 macrophage polarization, and its effect is offset by blocking autophagic flux. The role of mitochondrial ROS in lysosome dysfunction and M1 macrophage polarization is also demonstrated in mitochondrial complex I defective RAW 264.7 cells induced by silencing NADH:ubiquinone oxidoreductase subunit-S4 (Ndufs4). These findings prove that mitochondrial ROS plays a key role in promoting macrophage polarization to inflammatory phenotype by impairing autophagy–lysosome system, which might provide clue to a novel treatment for diabetic complications.
ALMA resolves the hourglass magnetic field in G31.41+0.31
Authors: Beltrán M. T. , Padovani M. , Girart J. M. , Galli D. , Cesaroni R. , Paladino R. , Anglada G. , Estalella R. , Osorio M. , Rao R. , Sánchez-Monge Á. , Zhang Q. 
Published: August 2019

Context. Submillimeter Array (SMA) 870 μm polarization observations of the hot molecular core G31.41+0.31 revealed one of the clearest examples up to date of an hourglass-shaped magnetic field morphology in a high-mass star-forming region.
Aims. To better establish the role that the magnetic field plays in the collapse of G31.41+0.31, we carried out Atacama Large Millimeter/ submillimeter Array (ALMA) observations of the polarized dust continuum emission at 1.3 mm with an angular resolution four times higher than that of the previous (sub)millimeter observations to achieve an unprecedented image of the magnetic field morphology.
Methods. We used ALMA to perform full polarization observations at 233 GHz (Band 6). The resulting synthesized beam is 0′′.28×0′′.20 which, at the distance of the source, corresponds to a spatial resolution of ~875 au.
Results. The observations resolve the structure of the magnetic field in G31.41+0.31 and allow us to study the field in detail. The polarized emission in the Main core of G31.41+0.41is successfully fit with a semi-analytical magnetostatic model of a toroid supported by magnetic fields. The best fit model suggests that the magnetic field is well represented by a poloidal field with a possible contribution of a toroidal component of ~10% of the poloidal component, oriented southeast to northwest at approximately −44° and with an inclination of approximately −45°. The magnetic field is oriented perpendicular to the northeast to southwest velocity gradient detected in this core on scales from 103 to 104 au. This supports the hypothesis that the velocity gradient is due to rotation of the core and suggests that such a rotation has little effect on the magnetic field. The strength of the magnetic field estimated in the central region of the core with the Davis–Chandrasekhar-Fermi method is ~8–13 mG and implies that the mass-to-flux ratio in this region is slightly supercritical.
Conclusions. The magnetic field in G31.41+0.31 maintains an hourglass-shaped morphology down to scales of <1000 au. Despite the magnetic field being important in G31.41+0.31, it is not enough to prevent fragmentation and collapse of the core, as demonstrated by the presence of at least four sources embedded in the center of the core.
Hitze und Kälte in der Traditionellen Chinesischen Medizin: Zwei Fallbeispiele
Authors: Stockenreiter Josef 
Published: August 2019

ZusammenfassungDie Begriffe Hitze und Kälte in der Traditionellen Chinesischen Medizin (TCM) beziehen sich auf die Relation von Yin und Yang im Körper. Ihre klinischen Manifestationen hängen von der Kombination Fülle oder Leere ab. Die folgenden 2 Fallbeispiele beschreiben mögliche Behandlungsoptionen.
Effects of Two High-intensity Interval Training Concepts in Recreational Runners
Authors: Faelli Emanuela , Ferrando Vittoria , Bisio Ambra , Ferrando Mara , Torre Antonio La , Panasci Marco , Ruggeri Piero 
Published: August 2019

AbstractThis study investigated the effects induced by 8 weeks of two high-intensity interval training (HIIT) protocols, 10–20–30 and 30–30 concepts, characterized by significantly different training volume and intensity, on physiological parameters, running performance, body composition and psychophysiological stress of recreational divided into two groups: the 10–20–30 group performed two 10–20–30 sessions/wk and one continuous training (CT)/wk, whilst the 30–30 group performed two 30–30 sessions/wk and one CT session/wk. VO2max, 1 km time, maximal aerobic speed (MAS), and body composition were evaluated before and after intervention. Internal load was measured through rating of perceived exertion (RPE). Both groups significantly improved running performance (1 km time: p=0.04; MAS: p=0.000001), aerobic fitness (VO2max: p=0.000002) and body composition (lean mass (kg) p=0.0001; fat mass (%) p=0.00005). RPE resulted significantly lower in the 10–20–30 group than in 30–30 group (10–20–30: 13.36±0.28; 30–30:15.55±0.21; p=0.0002). Thus, the 10–20–30 group improved physiological parameters, performance and body composition, similar to 30–30 with significantly lower RPE values. These results suggest that in recreational runners the 10–20–30 training is effective in improving aerobic fitness and performance, with a lower subjective perception of effort, thus enhancing individual compliance and adherence to the prescribed training program.
Sequential multistenting protocol in biliary stenosis after liver transplantation: a prospective analysis
Authors: Tarantino Ilaria , Amata Michele , Cicchese Noemi , Ligresti Dario , Barresi Luca , Granata Antonino , Cipolletta Fabio , Tuzzolino Fabio , Traina Mario 
Published: August 2019

Abstract
Background Biliary complications are a serious source of morbidity after orthotopic and living-related liver transplantation. Endoscopic retrograde cholangiography (ERC) is the gold standard for patients with duct-to-duct anastomosis because it allows a direct approach for interventional procedures. A retrospective study showed results of a sequential multistenting protocol, without stent removal/exchange, with promising results. We conducted a prospective analysis to assess the clinical success, recurrence rate, and adverse event rate related to this protocol.
Methods From May 2012 to April 2018, all consecutive patients with a diagnosis of anastomotic stenosis following liver transplantation were enrolled in the study, and were followed for a period of at least 6 months after the last ERC. During the first ERC, a maximum number of plastic stents (10 Fr) were placed. In subsequent ERCs, scheduled every 3 months up to a maximum of 1 year, additional stents were inserted, as many as possible, without removing the previously placed stents.
Results From May 2012 to May 2018, 87 patients were included in the study and treated with a sequential multistenting protocol. The mean number of stents placed was 3.7 (SD 1.0). Clinical success (stricture resolution and normalization of cholestasis) was achieved in 86 patients (98.9 %). Seven patients (8.0 %) developed complications. Recurrence was recorded in seven patients (8.0 %) after a mean of 992.7 days (SD 622.1).
Conclusions This study represents the first prospective demonstration of the efficacy and safety of a sequential multistenting protocol. A key limitation of the study is the lack of a comparative group treated according to the traditional stent exchange approach.
Treatment of Central Nervous System Manifestations of HIV in the Current Era
Authors: Handoko Ryan , Spudich Serena 
Published: August 2019

AbstractTreatment of neurological, neurocognitive, and neuropsychiatric impairment in the setting of human immunodeficiency virus (HIV) infection remains a complex problem, given several possible mechanisms of pathogenesis. The etiology must be determined based on clinical judgment and objective evidence, including cerebrospinal fluid (CSF) data from lumbar puncture and neuroimaging information from magnetic resonance imaging, when available and indicated. Other neuroinfectious etiologies must be ruled out, including central nervous system (CNS) opportunistic infections. HIV replication in the CNS (including CSF escape) should be evaluated for and excluded. If CSF HIV is detected, we recommend a treatment switch to antiretrovirals (ARVs) targeted to address any CSF HIV resistance mutations identified, or empiric treatment intensification using ARVs with high CNS penetration. If CSF HIV is not detected, treatment intensification with CCR5 inhibitors may be considered as an adjunct to reduce neuroinflammation. Finally, the current ARV regimen must be examined for possible neurotoxicity. Efavirenz has been well-recognized for its neuropsychiatric adverse effects and potential for causing sleep disturbances. Similar concerns have recently been raised with integrase inhibitors, especially dolutegravir and raltegravir, although further studies are needed to determine the risks for clinically relevant neuropsychiatric side effects from these medications, given their overall high potency and proven success in treating systemic HIV.
Bacterial Infections of the Central Nervous System
Authors: LaPenna Paul A. , Roos Karen L. 
Published: August 2019

AbstractAcute bacterial meningitis and spinal epidural abscess are neurological emergencies. Acute bacterial meningitis may present with symptoms as nonspecific as headache and fever, but rapid progression to an altered level of consciousness is not unusual. Spinal epidural abscess manifests initially as back pain, followed by radicular pain, then weakness, and finally paraplegia. Brain abscess may initially present only with headache, or as a new-onset seizure or with a focal neurological deficit. Bacterial infections of the central nervous system require emergent diagnosis and management. In this article, the pathogenesis, etiological organisms, diagnostic studies, differential diagnosis and management of acute bacterial meningitis, spinal epidural abscess, and brain abscess are discussed.
Using Context-Sensitive Text Mining to Identify miRNAs in Different Stages of Atherosclerosis
Authors: Joppich Markus , Weber Christian , Zimmer Ralf 
Published: August 2019

790 human and mouse micro-RNAs (miRNAs) are involved in diseases. More than 26,428 miRNA–gene interactions are annotated in humans and mice. Most of these interactions are posttranscriptional regulations: miRNAs bind to the messenger RNAs (mRNAs) of genes and induce their degradation, thereby reducing the gene expression of target genes. For atherosclerosis, 667 miRNA–gene interactions for 124 miRNAs and 343 genes have been identified and described in numerous publications. Some interactions were observed through high-throughput experiments, others were predicted using bioinformatic methods, and some were determined by targeted experiments. Several reviews collect knowledge on miRNA–gene interactions in (specific aspects of) atherosclerosis.Here, we use our bioinformatics resource (atheMir) to give an overview of miRNA–gene interactions in the context of atherosclerosis. The interactions are based on public databases and context-based text mining of 28 million PubMed abstracts. The miRNA–gene interactions are obtained from more than 10,000 publications, of which more than 1,000 are in a cardiovascular disease context (266 in atherosclerosis). We discuss interesting miRNA–gene interactions in atherosclerosis, grouped by specific processes in different cell types and six phases of atherosclerotic progression. All evidence is referenced and easily accessible: Relevant interactions are provided by atheMir as supplementary tables for further evaluation and, for example, for the subsequent data analysis of high-throughput measurements as well as for the generation and validation of hypotheses. The atheMir approach has several advantages: (1) the evidence is easily accessible, (2) regulatory interactions are uniformly available for subsequent high-throughput data analysis, and (3) the resource can incrementally be updated with new findings.