bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propagations From Extreme Integrated Vapor Transport to Extreme Precipitation Events in North America
Authors: Li Xiaodong , Zhao Tongtiegang 
Published: November 2024

AbstractExtreme integrated vapor transport (IVT) is a crucial driving factor of extreme precipitation events (EPEs). This paper presents a complex network‐based characterization of propagations from extreme IVT to EPEs. Specifically, the propagations are tracked from extreme IVT to EPEs by event synchronization; and then the source zones of extreme IVT contributing to EPEs are identified by two‐layer complex network. A case study is devised for North America based on the daily NCEP/NCAR Reanalysis 1 from 1948 to 2021. Overall, eight communities of EPEs are identified: the west coast of United States (US) tend to receive substantial EPEs from the Pacific Ocean; the Gulf of Alaska tends to receive oceanic EPEs propagating inland; western Canada typically experiences large amount of out tendencies and the EPEs tend to accumulate in the Baffin Island and Labrador Peninsula; the southeastern US and the northern Great Plains tend to experience northward propagations from Mexico. Along the west coast of North America, the propagations from extreme IVT to EPEs typically originate from the eastern North Pacific between 160°W and 110°W, and make landfalls in 4 days. These propagations are influenced by anomalous cyclonic circulations developing over the Gulf of Alaska forced by eastward Rossby waves. The coincidence rate of these propagations with atmospheric rivers is, respectively, 85.31% in autumn, 91.35% in winter, 73.94% in spring, and 64.52% in summer. Overall, the observed propagations from extreme IVT to EPEs yield insights into the mechanism of atmospheric moisture transport and the predictability of precipitation.
Nitrate Loads From Land to Stream Are Balanced by In‐Stream Nitrate Uptake Across Seasons in a Dryland Stream Network
Authors: Handler Amalia M. , Helton Ashley M. , Grimm Nancy B. 
Published: November 2024

AbstractExploring nitrogen dynamics in stream networks is critical for understanding how these systems attenuate nutrient pollution while maintaining ecological productivity. We investigated Oak Creek, a dryland watershed in central Arizona, USA, to elucidate the relationship between terrestrial nitrate (NO3−) loading and stream NO3− uptake, highlighting the influence of land cover and hydrologic connectivity. We conducted four seasonal synoptic sampling campaigns along the 167‐km network combined with stream NO3− uptake experiments (in 370–710‐m reaches) and integrated the data in a mass‐balance model to scale in‐stream uptake and estimate NO3− loading from landscape to the stream network. Stream NO3− concentrations were low throughout the watershed (<5–236 μg N/L) and stream NO3− vertical uptake velocity was high (5.5–18.0 mm/min). During the summer dry (June), summer wet (September), and winter dry (November) seasons, the lower mainstem exhibited higher lateral NO3− loading (10–51 kg N km−2 d−1) than the headwaters and tributaries (<0.001–0.086 kg N km−2 d−1), likely owing to differences in irrigation infrastructure and near‐stream land cover. In contrast, during the winter wet season (February) lateral NO3− loads were higher in the intermittent headwaters and tributaries (0.008–0.479 kg N km−2 d−1), which had flowing surface water only in this season. Despite high lateral NO3− loading in some locations, in‐stream uptake removed >81% of NO3− before reaching the watershed outlet. Our findings highlight that high rates of in‐stream uptake maintain low nitrogen export at the network scale, even with high fluxes from the landscape and seasonal variation in hydrologic connectivity.
High blood pressure in the emergency department as an opportunistic screening tool for detection of hypertension
Authors: Bentzel Sara , Manhem Karin , Öhman Ottilia , Abdulla Karzan , Mourtzinis Georgios 
Published: November 2024

AbstractHypertension is the most preventable cause of morbidity and mortality, but many individuals are underdiagnosed and lack treatment control. High blood pressure (BP) in the emergency department (ED) is commonly observed, but mostly used for short-term evaluation. We aimed to study the usefulness of high BP in the ED as a screening tool for undiagnosed hypertension. We used the electronic medical record system to identify all patients that had attended the ED at a university hospital from 2018-01-01 to 2018-03-31 and from 2018-07-01 to 2018-09-30 with an obtained systolic BP ≥ 160 and/or diastolic BP ≥ 100 mmHg measured at the ED. We excluded patients with previously diagnosed hypertension and patients on BP-lowering medication. All patients identified where contacted two years after attending the ED, with a letter of consent and a questionnaire regarding diagnosis of hypertension and current medication. 5424 patients attended the ED during the 6-months-period. 271 patients met the inclusion criteria and were asked to participate. 167 individuals (62%) agreed to participate and responded to the questionnaire. Mean age of participants were 63.1 years and 51% were women. 134 patients (80%) had measured their BP after the ED-visit, and 48 (36%) of those had been diagnosed with hypertension. 96% of patients diagnosed with hypertension were on BP-lowering medication. To follow-up BP ≥ 160/100 mmHg after an ED visit can reveal undiagnosed hypertension in one third of the patients. Given the amount of undiagnosed hypertension, an ED-measured BP might provide an important tool to detect and start treatment of hypertension.
Association of whole blood essential metals with neurodevelopment among preschool children
Authors: Shen Ying , Zhang Wanting , Jin Huyi , Guo Fanjia , Jin Mingjuan , Chen Guangdi 
Published: November 2024

Abstract
Background
Essential metals may play roles in neurodevelopment. The aim was to evaluate the associations of magnesium (Mg), iron (Fe), copper (Cu), and zinc (Zn) levels with neurodevelopment among preschool children.

Methods
The medical records of eligible children enrolled between January 2019 and July 2022 were retrospectively reviewed for required information. The quantitative measurement of metals was conducted using atomic absorption spectroscopy, while screening of neurodevelopment was performed using the Ages and Stages Questionnaire. Modified Poisson regression and Bayesian kernel machine regression (BKMR) analyses were used to evaluate the prevalence ratio (PR) of their independent and joint associations.

Results
662 (14.8%) children were found to have possible neurodevelopmental delays. Modified Poisson regression showed that Mg, Cu, and Zn levels were independently and negatively associated with the risk of neurodevelopmental delay. The PRs (95% CIs) for per log2 increment of the above metals were 0.35 (0.19–0.62), 0.57 (0.42–0.77), and 0.63 (0.42–0.96). These negative associations were more pronounced in the gross motor and personal-social domains while considering the concrete five domains. BKMR showed a negative association of metal mixture with the risk of neurodevelopmental delay.

Conclusion
Mg, Cu, and Zn were inversely associated with neurodevelopmental delay. Sufficient essential metal levels are important for neurodevelopment.

Impact

Essential metals play a key role in neurodevelopment. The association of essential metal mixture with neurodevelopment is relatively scarce.

Preschool children with possible neurodevelopmental delay are found to have lower Mg, Cu, and Zn levels than their counterparts.

Single Mg, Cu, Zn levels, and elevated essential metal mixture are negatively associated with the risk of possible neurodevelopmental delay.
FATS inhibits the Wnt pathway and induces apoptosis through degradation of MYH9 and enhances sensitivity to paclitaxel in breast cancer
Authors: Song Jin-Xuan , Wang Yue , Hua Zhi-Peng , Huang Yue , Hu Lin-Fei , Tian Meng-Ran , Qiu Li , Liu Hong , Zhang Jun 
Published: November 2024

AbstractBreast cancer is one of the most prevalent and diverse malignancies, and, with global cases increasing, the need for biomarkers to inform individual sensitivity to chemotherapeutics has never been greater. Our retrospective clinical analysis predicted that the expression of the fragile site-associated tumor suppressor (FATS) gene was associated with the sensitivity of breast cancer to neoadjuvant chemotherapy with paclitaxel. In vitro experiments subsequently demonstrated that FATS significantly increased the inhibitory effects of paclitaxel on breast cancer cells’ migration, growth, and survival. An interaction screen revealed that FATS interacted with MYH9 and promoted its degradation via the ubiquitin-proteasome pathway, thereby downregulating Wnt signaling. By overexpressing FATS and MYH9, we demonstrated that FATS enhanced paclitaxel-induced apoptosis in breast cancer cells by degrading MYH9 to downregulate the Wnt pathway. We also demonstrated in a mouse xenograft model that FATS significantly increased the chemosensitivity of breast cancer cells to paclitaxel in vivo. This study presents a new mechanism by which FATS interacts with MYH9 to suppress the Wnt/β-catenin signaling pathway and induce apoptosis, thus enhancing the sensitivity of breast cancer cells to paclitaxel chemotherapy. The results also propose novel biomarkers for predicting breast cancer sensitivity to neoadjuvant chemotherapy with paclitaxel. Finally, we provide in vivo evidence that the combination of paclitaxel with IWR-1, a novel Wnt pathway inhibitor, synergistically suppresses breast cancer growth, laying the foundation for future trials with this drug combination. These results therefore provide a number of potential solutions for more precise treatment of patients with breast cancer in the future.
EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial sarcoma
Authors: Mushtaq Muhammad , Liaño-Pons Judit , Wang Jiansheng , Alzrigat Mohammad , Yuan Ye , Ruiz-Pérez María Victoria , Chen Yi , Kashuba Elena , Haglund de Flon Felix , Brodin Bertha , Arsenian-Henriksson Marie 
Published: November 2024

AbstractSynovial sarcoma (SS) is driven by a unique t(18;X) chromosomal translocation resulting in expression of the SS18-SSX fusion oncoprotein, a transcriptional regulator with both activating and repressing functions. However, the manner in which SS18-SSX contributes to the development of SS is not entirely known. Here, we show that SS18-SSX drives the expression of Preferentially Expressed Antigen in Melanoma (PRAME), which is highly expressed in SS but whose function remains poorly understood. The fusion protein directly binds and activates the PRAME promoter and we found that expression of SS18-SSX and PRAME are positively correlated. We provide evidence that PRAME modulates retinoic acid (RA) signaling, forming a ternary complex with the RA receptor α (RARα) and the Enhancer of Zeste Homolog 2 (EZH2). Knockdown of PRAME suppressed the response to all-trans retinoic acid (ATRA) supporting PRAME’s role in modulating RA-signaling. Notably, we demonstrate that combined pharmacological inhibition of EZH2 and treatment with ATRA reconstituted RA signaling followed by reduced proliferation and induction of cellular senescence. In conclusion, our data provides new insights on the role of the SS18-SSX fusion protein in regulation of PRAME expression and RA signaling, highlighting the therapeutic potential of disrupting the RARα-PRAME-EZH2 complex in SS.
Broad-spectrum inflammasome inhibition by thiomuscimol
Authors: Anderson Marisa J. , den Hartigh Andreas B. , Loomis Wendy P. , Fink Susan L. 
Published: November 2024

AbstractInflammasome formation, arising from pathogen or internal activating signals, is a key step in canonical pyroptosis, a gasdermin-mediated inflammatory cell death. Inhibition of pyroptosis has great clinical relevance due to its involvement in many different disease states. Current inhibitors of pyroptosis either only inhibit the final lytic step, which still allows inflammatory signal release, or only inhibit a single inflammasome, which does not account for inherent redundancy in activation of other inflammatory pathways. Here, we show that thiomuscimol, a structural analog of the lysis inhibitor muscimol, exhibits unique inhibitory activity upstream of plasma membrane rupture. We find that thiomuscimol inhibits inflammasome formation, as well as downstream caspase-1 activation, initiated by multiple pyroptotic signals, regardless of whether NLR recruitment of caspase-1 to the inflammasome relies on the ASC adapter protein. The ability of thiomuscimol to block multiple different inflammasomes opens the door for development of therapeutics with increased applications to broadly inhibit pyroptosis in multiple pathological settings.
Web-based pulmonary telehabilitation: a systematic review
Authors: Ayala-Chauvin Manuel , Chicaiza Fernando A. , Acosta-Vargas Patricia , Jadan Janio , Maldonado-Garcés Verónica , Ortiz-Prado Esteban , Acosta-Vargas Gloria , Carrión-Toro Mayra , Santórum Marco , Gonzalez-Rodriguez Mario , Madera Camila , Esparza Wilmer 
Published: November 2024

AbstractWeb-based pulmonary telerehabilitation (WBPTR) can serve as a valuable tool when access to conventional care is limited. This review assesses a series of studies that explore pulmonary telerehabilitation programmes delivered via web-based platforms. The studies involved participants with moderate to severe chronic obstructive pulmonary disease (COPD). Of the 3190 participants, 1697 engaged in WBPTR platforms, while the remaining 1493 comprised the control groups. Sixteen studies were included in the meta-analysis. Web-based pulmonary telerehabilitation led to an increase in daily step count (MD 446.66, 95% CI 96.47 to 796.86), though this did not meet the minimum clinically important difference. Additionally, WBPTR did not yield significant improvements in the six-minute walking test (MD 5.01, 95% CI − 5.19 to 15.21), health-related quality of life as measured by the St. George’s Respiratory Questionnaire (MD − 0.15, 95% CI − 2.24 to 1.95), or the Chronic Respiratory Disease Questionnaire (MD 0.17, 95% CI − 0.13 to 0.46). Moreover, there was no significant improvement in dyspnoea-related health status, as assessed by the Chronic Respiratory Disease Questionnaire (MD − 0.01, 95% CI − 0.29 to 0.27) or the modified Medical Research Council Dyspnoea Scale (MD − 0.14, 95% CI − 0.43 to 0.14). Based on these findings, this review concludes that WBPTR does not offer substantial advantages over traditional care. While slight improvements in exercise performance were observed, no meaningful enhancements were noted in dyspnoea or quality of life metrics. Overall, WBPTR remains a complementary and accessible option for managing and monitoring COPD patients. However, further research and innovation are required to improve its efficacy and adapt it to various clinical environments.
Improved nutritional value of surplus bread and perennial ryegrass via solid-state fermentation with Rhizopus oligosporus
Authors: Sandoval Juan F. , Gallagher Joe , Rodriguez-Garcia Julia , Whiteside Kerry , Bryant David N. 
Published: November 2024

AbstractSolid-state fermentation (SSF) is a sustainable method to convert food waste and plant biomass into novel foods for human consumption. Surplus bread crusts (BC) have the structural capacity to serve as an SSF scaffold, and their nutritional value could be increased in combination with perennial ryegrass (PRG), a biorefining feedstock with high-quality protein but an unpleasant sensory profile. SSF with Rhizopus oligosporus was investigated with these substrates to determine if the overall nutritional value could be increased. The BC-PRG SSFs were conducted for up to 72 h, over which time the starch content had decreased by up to 89.6%, the total amino acid (AA) content increased by up to 141.9%, and the essential amino acid (EAA) content increased by up to 54.5%. The BC-PRG SSF demonstrated that this process could potentially valorise BC and PRG, both widely available but underexplored substrates, for the production of alternative proteins.
Future land use maps for the Netherlands based on the Dutch One Health Shared Socio-economic Pathways
Authors: Dellar Martha , Geerling Gertjan , Kok Kasper , van Bodegom Peter M. , van der Schrier Gerard , Schrama Maarten , Boelee Eline 
Published: November 2024

AbstractTo enable detailed study of a wide variety of future health challenges, we have created future land use maps for the Netherlands for 2050, based on the Dutch One Health Shared Socio-economic Pathways (SSPs). This was done using the DynaCLUE modelling framework. Future land use is based on altitude, soil properties, groundwater, salinity, flood risk, agricultural land price, distance to transport hubs and climate. We also account for anticipated demand for different land use types, historic land use changes and potential spatial restrictions. These land use maps can be used to model many different health risks to people, animals and the environment, such as disease, water quality and pollution. In addition, the Netherlands can serve as an example for other rapidly urbanising deltas where many of the health risks will be similar.
Atmospheric new particle formation identifier using longitudinal global particle number size distribution data
Authors: Kecorius Simonas , Madueño Leizel , Lovric Mario , Racic Nikolina , Schwarz Maximilian , Cyrys Josef , Casquero-Vera Juan Andrés , Alados-Arboledas Lucas , Conil Sébastien , Sciare Jean , Ondracek Jakub , Hallar Anna Gannet , Gómez-Moreno Francisco J. , Ellul Raymond , Kristensson Adam , Sorribas Mar , Kalivitis Nikolaos , Mihalopoulos Nikolaos , Peters Annette , Gini Maria , Eleftheriadis Konstantinos , Vratolis Stergios , Jeongeun Kim , Birmili Wolfram , Bergmans Benjamin , Nikolova Nina , Dinoi Adelaide , Contini Daniele , Marinoni Angela , Alastuey Andres , Petäjä Tuukka , Rodriguez Sergio , Picard David , Brem Benjamin , Priestman Max , Green David C. , Beddows David C. S. , Harrison Roy M. , O’Dowd Colin , Ceburnis Darius , Hyvärinen Antti , Henzing Bas , Crumeyrolle Suzanne , Putaud Jean-Philippe , Laj Paolo , Weinhold Kay , Plauškaitė Kristina , Byčenkienė Steigvilė 
Published: November 2024

AbstractAtmospheric new particle formation (NPF) is a naturally occurring phenomenon, during which high concentrations of sub-10 nm particles are created through gas to particle conversion. The NPF is observed in multiple environments around the world. Although it has observable influence onto annual total and ultrafine particle number concentrations (PNC and UFP, respectively), only limited epidemiological studies have investigated whether these particles are associated with adverse health effects. One plausible reason for this limitation may be related to the absence of NPF identifiers available in UFP and PNC data sets. Until recently, the regional NPF events were usually identified manually from particle number size distribution contour plots. Identification of NPF across multi-annual and multiple station data sets remained a tedious task. In this work, we introduce a regional NPF identifier, created using an automated, machine learning based algorithm. The regional NPF event tag was created for 65 measurement sites globally, covering the period from 1996 to 2023. The discussed data set can be used in future studies related to regional NPF.
Altered expression of Csnk1a1p in Autism Spectrum Disorder in Iranian population: case-control study
Authors: Rahmani Zahra , Rahmani Dina , Jazi Marie Saghaeian , Ghasemi Mohammad-Reza , Sadeghi Hossein , Miryounesi Mohammad , Razjouyan Katayoon , Fayyazi Bordbar Mohammad Reza 
Published: November 2024

AbstractOver the past decade, substantial scientific evidence has showed that long non-coding RNAs (lncRNAs) are extensively expressed and play a crucial role in gene modulation through a diverse range of transcriptional, and post-transcriptional mechanisms. Recent discoveries have emphasized the involvement of lncRNAs in maintaining cellular homeostasis and neurogenesis in the brain. Accumulating reports identified dysregulated lncRNAs associated with psychiatric disorders, including autism. In this study, we examined the expression levels of DISC2, Linc00945, Foxg1-as1, Csnk1a1p, and Evf2 lncRNAs in blood samples from 21 clinically diagnosed autistic patients based on the Diagnostic and Statistical Manual of Mental Disorders criteria-5th edition (DSM-5), compared to age, sex, and ethnically-matched 25 healthy individuals. RNA extraction and cDNA synthesis were performed, followed by real-time PCR for quantification of lncRNAs expression levels. Receiver operating characteristic (ROC) curve analysis was used to evaluate biomarker potential. Additionally, we investigated the correlation between gene expression levels and autism comorbidities. Our results showed a significant decrease in Csnk1a1p expression in patients with autism spectrum disorder (ASD) compared to healthy children (P value = 0.0008). ROC curve analysis indicated that Csnk1a1p expression levels could effectively discriminate patients from healthy controls (AUC = 0.837, P value = 0.000284). No significant differences were observed between Csnk1a1p expression levels and comorbidity with ADHD or intellectual disability (p-value > 0.05). Based on these findings, Csnk1a1p may play a significant role in autistic patients and could serve as a potential biomarker for diagnostic and predictive purposes, as well as a therapeutic target.
Predictors of explicit and implicit anthropomorphism in house facades
Authors: Weber Sandra , Roessler Kirsten Kaya , Riebandt Kevin , Kühn Simone 
Published: November 2024

AbstractAnthropomorphism describes the tendency to endow objects with human characteristics, with some individuals being more inclined to do this than others. In an ambiguous environment, this phenomenon can offer guidance. This study investigates the relationship between self-reported attribution and evoked anthropomorphism when viewing house facades. Data was collected from three countries (Germany, Denmark, Canada; N = 305). Implicit house anthropomorphism was measured using the Global Vectors for Word Representation method. Explicit anthropomorphism was assessed using the Individual Differences in Anthropomorphism Questionnaire (IDAQ) and a specific House Anthropomorphism Score (EHAS). No significant relationship was found between implicit and explicit house anthropomorphism. Individual IDAQ scores were significantly associated with EHAS across all participants, regardless of country. Additionally, a high degree of agreement in explicit ratings between countries suggests that cultural differences are rather negligible. When objects are given human personality traits and people interact with them because emotions are triggered, it is important to understand which aspects elicit positive and reactive behaviors. In particular, houses, which have high psychological significance as objects of self-expression, might contribute to well-being, so research in this area can provide important knowledge for urban design and architecture.