bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telomere length across the spectrum of metabolic health – an analysis from the LIPIDOGEN2015 study
Authors: Banach Maciej , Fronczek Martyna , Goc Anna , Lejawa Mateusz , Boniewska-Bernacka Ewa , Osadnik Tadeusz , Pańczyszyn Anna , Strzelczyk Joanna Katarzyna , Pawlas Natalia , Gierlotka Marek , Goławski Marcin , Krystek Karol , Gach Agnieszka , Osadnik Kamila , Jóźwiak Jacek 
Published: October 2024

IntroductionBackground: Telomere length is a cellular aging marker and correlates with various cardiovascular disease (CVD) risk factors. The current study assessed the association between obesity, metabolic syndrome (MetS), and telomere length.Material and methodsMaterial and methods: The LIPIDOGRAM&LIPIDOGEN2015 study was conducted in primary care in 2015-2016. Recruited patients to the LIPIDOGEN2015 cohort (n=1788) were a random subset of patients of the LIPIDOGRAM2015 (n=13,724) study. For the aims of this analysis, the recruited patients were divided into four groups based on the presence of MetS: healthy slim (HS), metabolically healthy obese (MHO), non-obese with MetS (NOMS), and metabolically unhealthy obese (MUO). Relative telomere length (RTL) was measured using quantitative polymerase chain reaction (qPCR).ResultsResults: 1516 patients (85%; females - 59.7%, mean age- 50.3 years) were included for final analyses. An increase in body mass index (BMI), waist circumference, prevalence of diabetes mellitus, hypertension, dyslipidemia, and history of myocardial infarction moving from HS to MUO were observed. MUO group exhibited the highest triglycerides and lowest high-density lipoprotein (HDL-C) levels. Univariable regression analyses indicated that NOMS (p=0.038) and MUO (p=0.003) were associated with significantly decreased RTL. After adjustment for age, gender, education, smoking, place of residence, and myocardial infarction, the association was no longer statistically significant.ConclusionsConclusions: Despite the lack of statistical significance in the multivariate analysis, the univariate results suggest that both MUO and NOMS phenotypes contribute to the shortening of telomere length. These results may also indicate that MetS, irrespectively on obesity occurrence, is responsible for the shortened lifespan.
Strategi Optimalisasi Beban Administratif Guru SD Muhammadiyah 3 Pandaan melalui Penggunaan Aplikasi Digital "SIDIKMU"
Authors: Nadifa Milatun , Supriyanto Achmad , Rochmawati Rochmawati 
Published: October 2024

Penelitian ini bertujuan untuk mengevaluasi penggunaan aplikasi digital dalam mengurangi beban administratif guru di SD Muhammadiyah 3 Pandaan. Dalam era digital, beban kerja administratif yang berlebihan dapat mengganggu kualitas pembelajaran. Integrasi teknologi digital dalam manajemen sekolah menjadi solusi utama. menggunakan pendekatan kualitatif dengan lokasi di SD Muhammadiyah 3 Pandaan. Informan dalam penelitian ini meliputi kepala sekolah, wakil kepala sekolah bidang hubungan masyarakat, dan empat orang guru kelas. Pengumpulan data dilakukan melalui wawancara dan dokumentasi. Analisis data menggunakan pendekatan tematik dengan langkah-langkah berupa transkripsi wawancara, identifikasi tema-tema utama dari data yang terkumpul, penyusunan temuan, dan validasi data dengan partisipan untuk memastikan akurasi dan kedalaman pemahaman. Hasilnya menunjukkan manfaat signifikan aplikasi tersebut, seperti meningkatkan efisiensi dan fokus pada pengajaran. Temuan penelitian ini menggarisbawahi pentingnya optimalisasi penggunaan aplikasi digital dapat meningkatkan mutu pendidikan. Strategi PDCA digunakan untuk memastikan implementasi yang berhasil. Penelitian lebih lanjut diperlukan untuk mengembangkan aplikasi digital yang lebih efektif di berbagai konteks pendidikan.
Dinámica del cambio de uso de suelo y cobertura vegetal en una microcuenca del río Pantepec, Hidalgo, México
Authors: María G. Hinojosa-Pérez , Acevedo-Sandoval Otilio A. , Vázquez-Cuevas Gabriela M. , Jessica Bravo-Cadena  , Navarro-Gómez Humberto I. , Razo-Zárate Ramón , Valencia-Pulido Silvana B. 
Published: October 2024

Introducción. El análisis del cambio de cobertura y uso del suelo (CCUS) permite la identificación de factores que generan cambios en los ecosistemas.
Objetivo. Analizar la dinámica del CCUS en una microcuenca del río Pantepec en la región Otomí-Tepehua, Hidalgo, durante el periodo 1993-2018.
Materiales y métodos. Con datos vectoriales de la serie II (1993), IV (2007) y VII (2018) del Instituto Nacional de Estadística y Geografía (INEGI) y mediante una clasificación no supervisada en QGIS 2.18.10, se identificaron siete categorías de uso de suelo y cobertura vegetal. La herramienta MOLUSCE (Modules for Land Use Change Evaluation) de QGIS 2.18.10 se empleó para la obtención de matrices y mapas de cambio. Para tres periodos de análisis, se calcularon la tasa de cambio, pérdida, ganancia, cambio total y neto e intercambio entre categorías. Resultados y discusión. Entre 1993 al 2018 existió un proceso de pérdida y ganancia en el bosque mesófilo de montaña con una tasa de cambio de -3.21 %, impulsado por el pastizal inducido y la agricultura de temporal con tasas de cambio de 3.75 y -2.38 % respectivamente. En 25 años, la agricultura de temporal perdió 57 % de superficie y el pastizal inducido aumentó 251 %.
Conclusiones. Las categorías de usos de suelo con cambios significativos se ubican en los alrededores de San Bartolo Tutotepec, influenciadas por actividades antrópicas. Existen variaciones en las categorías de bosque, atribuidas a cambios en la metodología de clasificación del INEGI entre las series II, IV y VII.
Exploring links between visuospatial ability and anatomy learning in education: A bibliometric analysis and scientific mapping
Authors: Rahmani Muhammad Z. , Bukhari Agussalim , Wiyono Nanang , Amru Khaeriah , Baharuddin Baharuddin , Nurhadi Asty A. 
Published: October 2024

The field of medical education faces a significant challenge in teaching human anatomy, a fundamental aspect of medical science that is often perceived as complex and demanding. Understanding the shapes and anatomical structure locations is crucial for students to master the intricacies of anatomy. Visuospatial ability, which involves comprehending three-dimensional structures and their spatial relationships, plays a pivotal role in anatomy learning. The aim of this study was to examine keywords, territories/countries, the number of publications, institutions, authors, and associated journals related to visuospatial ability in anatomy learning through extensive bibliometric analysis. Data were gathered from the Scopus database, and VOSviewer was employed to conduct a bibliometric analysis. Approximately 552 eligible articles were examined in their entirety. The findings indicated that the most significant research growth occurred in 2012, with the United States of America emerging as the leading country in the field. Furthermore, Anatomical Science Education was recognized as the most esteemed journal in this field, with Wilson, T.D. being credited as the most influential author. The bibliometric data also demonstrated various approaches to improve visuospatial capacity in anatomy learning, such as utilizing virtual reality or other computer-assisted learning modalities and their integration into medical education practice. In conclusion, these findings highlight the critical role of visuospatial ability in facilitating the acquisition of anatomical knowledge and offer direction for future research in this area.
Diagnostic accuracy of urinary cytokeratin fragment-19 (CYFRA21-1) for bladder cancer
Authors: Setianingsih Yennie A. , Djatisoesanto Wahjoe , Laksita Tetuka B. , Aryati Aryati 
Published: October 2024

Bladder cancer is known for its high recurrence rate and requires constant patient monitoring. To confirm the diagnosis, a tissue sample from a cystoscopy is required, which the patient often avoids. Urine has the potential to be utilized as a diagnostic fluid because of its non-invasive nature and various biomarker contents. The aim of this study was to determine the diagnostic value of cytokeratin fragment-19 (CYFRA21-1) level in urine for diagnosing bladder cancer. This single-center cross-sectional study was performed with eligible inclusion were adults aged ≥18 years who presented with hematuria and suspected bladder cancer from imaging. Patients with a history of intravesical chemotherapy, radiotherapy and immunotherapy were excluded. Urine samples were collected prior to the cystoscopy. Detection of urinary CYFRA21-1 was carried out using the ELISA method. Of 154 patients included in the study, the diagnosis of bladder cancer was confirmed in 92 patients. Patients with bladder cancer had significantly higher urinary CYFRA21-1 levels compared to the non-bladder cancer group. The sensitivity, specificity, positive and negative predictive value, and positive likelihood ratio of the CYFRA21-1 were 80.4%, 43.5%, 67.9%, 60% and 1.425, respectively. The area under the curve for CYFRA21-1 was 0.608, computed from a receiver operating curve with a cut-off value of 13.3 ng/mL. In conclusion, urinary CYFRA21-1 levels have moderate diagnostic accuracy in determining bladder cancer among suspected individuals. Due to its high sensitivity, this biomarker could potentially be used alongside other screening tools for bladder cancer detection.
Choice of hernioplasty method based on the degree of intra-abdominal hypertension
Authors: Bokiev F. B. , Gaibov A. D. , Malikov M. Kh. , Makhmadkulova N. A. , Khudoydodov O. M. 
Published: October 2024

Aim. To study the variability of intra-abdominal pressure and the choice of hernioplasty method for large and giant abdominal hernias.Material and Methods. This study analyzed the outcomes of various hernial orifice repair methods in 134 patients with large and giant hernias of the anterior and lateral abdominal walls. The majority of cases involved incisional hernias (n=52), while 47 patients presented with recurrent hernias, and 35 cases involved primary hernias. In 84.3% of cases, the hernias were localized in the anterior abdominal wall, and concomitant comorbidities were identified in 82 patients. Preoperative evaluations included clinical examination, imaging studies, and assessment of intra-abdominal pressure. Research results. In 31 (29.2%) observations, hernia repair was performed using the inlay method due to high intra-abdominal pressure. Anterior and posterior component separation with prosthetic reinforcement using the sub lay technique was carried out in 21 patients (7.5%). Additionally, the placement of a mesh prosthesis using the on lay method was performed in 54 patients (20.7%). The overall mortality rate was 2.2% (n=3), while 11 patients experienced recurrence in the late postoperative period, resulting in a recurrence rate of 8.2%.Conclusion. The increasing frequency of abdominal and retroperitoneal surgeries has led to a rise in the incidence of abdominal hernias. Traditional hernia repair techniques continue to evolve, and new, minimally invasive approaches are being developed to enhance patient outcomes. Despite ongoing advancements in surgical techniques for large and giant abdominal hernias, several challenges remain unresolved, necessitating further research and innovation in this field.
Features of body mass index in pregnant women with SARS-CoV-2-associated pneumonia
Authors: Davlyatova M. F. , Karimova D. G. , Abduvalieva M. A. 
Published: October 2024

Aim. To evaluate BMI in pregnant women with SARS-CoV-2-associated pneumonia and its influence on the severity of the course of viral pneumonia.Materials and Methods. Seventy pregnant women with SARS-CoV-2-associated pneumonia underwent general clinical and laboratory evaluations. SARS-CoV-2 infection was confirmed using PCR diagnostic testing, and imaging studies, including chest radiography in two views or computed tomography, were performed.Results. Analysis of BMI in pregnant women with SARS-CoV-2-associated pneumonia revealed that 11 patients (15.7%) were classified as overweight (BMI 25 to 30). Obesity was identified in 9 patients (12.9%), including 6 cases (8.6%) with first-degree obesity (BMI 30 to 35) and 3 cases (4.3%) with second-degree obesity (BMI 35 to 40). A body weight deficit (BMI < 18.5) was observed in 9 patients (12.9%).Conclusion. In the study group, BMI-related pathology was prevalent, with half of the pregnant women with SARS-CoV-2-associated pneumonia presenting as either overweight, obese, or underweight. BMI correlated with the clinical forms of SARS-CoV-2-associated pneumonia. The frequency of BMI-associated pathology increased fourfold in complicated forms of SARS-CoV-2-associated pneumonia compared to moderately severe forms.
Healing properties of natural mineral water of Tajikistan
Authors: Saidzoda B. I. , Mamadaminov O. N. 
Published: October 2024

Aim. To study the composition and medicinal properties of water from natural mineral springs in the Republic of Tajikistan.Materials and Methods. This study analyzed the climatic and geographical regions, as well as the water quality and chemical composition of four mineral springs: Khoja-Obi-Garm, Obi-Garm, Garm-Chashma, and Shoambary. The research also investigated the influence and effectiveness of these mineral waters in treating skin diseases.Results and Discussion. The Republic of Tajikistan has numerous mineral springs that are used for treating skin conditions and other health issues. Mineral waters in Tajikistan are classified into five types based on their chemical composition: bicarbonate, chloride, sulfate, nitrate, and mixed composition waters. In addition, there are waters with active ions and gaseous elements such as hydrogen sulfide, radon, nitrogen, and methane. Based on temperature, these waters are categorized as cold, warm, or hot/thermal waters. The springs at Khoja-Obi-Garm, Obi-Garm, Garm-Chashma, and Shoambary are hot thermal baths of the bicarbonate-chloride-sulfate-sodium type. In addition to the primary salts and gases, these waters contain biologically active trace elements, including aluminum, titanium, manganese, copper, silicon, molybdenum, strontium, barium, boron, fluorine, and others.Conclusion. Tajikistan holds a leading position in Central Asia regarding the abundance of mineral springs, and the mineral waters from these springs meet the requirements for therapeutic use. These waters contain a variety of chemical elements that exert significant biological effects, and, when used appropriately, can effectively treat many diseases.
Food Safety Policy, Implications for MSME Green Economy Based Product Processing
Authors: Rudiatin Endang , Putri Dessy Iriani , Rahma Irhamni 
Published: October 2024

Processed food production plants are implementing the Food Safety Risk Management Program in accordance with BPOM Regulation Number 10 of 2023. Indonesian food safety surveillance is based on a preventive, risk-based paradigm where producers bear the main responsibility for food safety. The research's objective is to offer solutions to micro, small, and medium-sized firms (MSMEs) so that these businesses may also guarantee the quality and safety of their goods while working within the constraints of available facilities and resources for manufacturing and distribution.The study's conclusions imply that MSMEs should receive risk management training for food safety, which should include instruction on how to integrate halal practices into their production processes. Through zero waste, environmental friendliness, and energy efficiency, this research presents a strategy for implementing technological innovation based on a green economy. The basic concept of halal products requires business operators to manage the food processing in a series that includes zero waste activities, environmentally friendly practices, and energy efficiency within a single production process. This process is ensured to be an implementation of food safety risk management programs. The research's conclusions suggest that MSME actors could find it easier to understand and implement this strategy. Now that the risks to food security have been eliminated, the halal certification procedure can proceed.
Improvizing West Java MSMEs Using Quality Service Gaps Model
Authors: H Putri Afisindika Fadhilah , Novani Santi 
Published: October 2024

This study aims to understand the challenges and opportunities for the development of Micro, Small and Medium Enterprises (MSMEs) in West Java. With a very large number, MSMEs in West Java have great potential to drive economic growth. However, various obstacles such as access to capital, information, and technology are still an obstacle. This research proposes the application of the Service Science framework to map the MSME ecosystem and identify opportunities for service innovation. Thus, it is expected to increase the competitiveness of MSMEs and make a greater contribution to the regional economy. This research reveals that MSMEs in West Java face significant constraints in terms of access to capital, information, and technology. Through in-depth interviews with 8 MSME owners, this research aims to understand in-depth the challenges and opportunities faced by micro, small and medium enterprises. Thematic analysis of the interview data identified a gap between the ideal conditions that MSMEs desire and the actual conditions they experience. Using the Service Quality Gap Model, this study created four action plans to improve MSMEs in West Java. By addressing the identified gaps and encouraging collaboration between MSMEs, government, academia and industry, the Sadulur platform can catalyze the sustainable growth and development of MSMEs in West Java. These gaps, which we refer to as 'customer gaps', are manifested in four main themes: 1) the potential for MSMEs to create innovative products more easily, 2) the need to develop a strong business foundation and build sustainable brand value, 3) the importance of improving business processes and management to increase efficiency, and 4) the need to build good relationships with external parties to expand networks and business opportunities. These findings form the basis for formulating an action plan to improve the quality of services provided to MSMEs.
Delta shock index predicts injury severity, interventions, and outcomes in trauma patients: A 10-year retrospective observational study
Authors: Asim Mohammad , El-Menyar Ayman , Ahmed Khalid , Al-Ani Mushreq , Mathradikkal Saji , Alaieb Abubaker , Hammo Abdel Aziz , Taha Ibrahim , Kloub Ahmad , Al-Thani Hassan 
Published: October 2024

BACKGROUND
Most trauma occurs among young male subjects in Qatar. We examined the predictive values of the delta shock index (DSI), defined as the change in the shock index (SI) value from the scene to the initial reading in the emergency unit (i.e. , subtracting the calculated SI at admission from SI at the scene), at a Level 1 trauma center.
AIM
To explore whether high DSI is associated with severe injuries, more interventions, and worse outcomes [i.e. , blood transfusion, exploratory laparotomy, ventilator-associated pneumonia, hospital length of stay (HLOS), and in-hospital mortality].
METHODS
A retrospective analysis was conducted after data were extracted from the National Trauma Registry between 2011 and 2021. Patients were grouped based on DSI as low (≤ 0.1) or high (> 0.1). Data were analyzed and compared using χ 2 and Student’s t -tests. Correlations between DSI and injury severity score (ISS), revised trauma score (RTS), abbreviated injury scale (AIS), Glasgow coma scale (GCS), trauma score-ISS (TRISS), HLOS, and number of transfused blood units (NTBU), were assessed using correlation coefficient analysis. The diagnostic testing accuracy for predicting mortality was determined using the validity measures of the DSI. Logistic regression analysis was performed to identify predictors of mortality.
RESULTS
This analysis included 13212 patients with a mean age of 33 ± 14 years, and 24% had a high DSI. Males accounted for 91% of the study population. The trauma activation level was higher in patients with a high DSI (38% vs 15%, P = 0.001). DSI correlated with RTS (r = -0.30), TRISS (r = -0.30), NTBU (r = 0.20), GCS (r = -0.24), ISS (r = 0.22), and HLOS (r = 0.14) (P = 0.001 for all). High DSI was associated with significantly higher rates of intubation, laparotomy, ventilator-associated pneumonia, massive transfusion activation, and mortality than low DSI. For mortality prediction, a high DSI had better specificity, negative predictive value, and negative likelihood ratio (77%, 99%, and 0.49%, respectively). After adjusting for age, emergency medical services time, GCS score, and ISS, multivariable regression analysis showed that DSI was an independent predictor of mortality (odds ratio = 1.9; 95% confidence interval: 1.35-2.76).
CONCLUSION
In addition to sex-biased observations, almost one-quarter of the study cohort had a higher DSI and were mostly young. High DSI correlated significantly with the other injury severity scores, which require more time and imaging to be ready to use. Therefore, DSI is a practical, simple bedside tool for triaging and prognosis in young patients with trauma.
Visionary Leadership In Improving The Quality Of Education
Authors: Wahyuningtyas Agustin , Hadiyati Ernani , Nasir M. Jamal Abdul 
Published: October 2024

This study aims to analyze visionary leadership strategies in improving the quality of education. This research was conducted at Permata Mojokerto Integrated Islamic Junior High School, East Java. This study uses a qualitative research approach. The informants are the Head of Education of YPM, the vice principal, teachers and the committee/parents of students. The results of the study concluded that visionary leadership at SMPIT Permata Mojokerto, East Java is as follows: as a direction determinant by doing several ways, namely: sharing sessions, developing strategies, making changes, enabling and empowering, motivating and inspiring, collaborating and being role models, so that visionary leadership is able to make strategies in improving the quality of education, namely: human resource development, strengthening the role of parents, curriculum development and fulfillment of adequate infrastructure. In the end, visionary leadership produces activities including improving the quality of human resources for educators and education personnel, improving the quality of graduates and effective and varied learning methods, as well as fulfilling adequate infrastructure