bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESIGN, DEVELOPMENT AND CHARACTERIZATION OF PACLITAXEL LOADED SOLID LIPID NANOPARTICLES AS A COLLOIDAL DRUG CARRIER
Authors: RAUT INDRAYANI D. , MANJAPPA AREHALLI S. , MOHITE SHRINIVAS K. , DOIJAD RAJENDRA C. 
Published: July 2019

Objective: This study was aimed to design and characterize Paclitaxel-loaded Solid Lipid Nanoparticles (SLNs) to achieve site specificity,reduce toxicity and sustained release pattern.
Methods: Paclitaxel-loaded solid lipid nanoparticles were fabricated by microemulsion followed by probe sonication technique using stearic acid as lipid and stabilized of the mixture of surfactants. In this study, 32 full factorial design was employed for optimizing the concentration of lipid as stearic acid and surfactant (soya lecithin) for the nanoparticles. The optimization was done by studying the dependent variable of particle size and % entrapment efficiency.
Results: The results showed that the paclitaxel-loaded solid lipid nanoparticles prepared with the concentration of 33.31 % stearic acid and 500 mg of soya lecithin were optimum characteristic than other formulations. They showed the average particles size 149±4.10 nm and PDI 250±2.04. The zeta potential, % EE and % drug loading capacity was found to be respectively-29.7, 93.38±1.90 and 0.81±0.01. The optimized batch of Paclitaxel SLNs exhibited spherical shape with smooth surface analyzed by Transmission Electron Microscopy. In vitro study showed sustained release profile and was found to follow Higuchi Kinetics Equation.
Conclusion: The SLNs of paclitaxel m et al. l the requirements of a colloidal drug delivery system. They had a particle size in nanosize; their size distribution was narrow and all the particles were in a spherical shape.
OPTIMIZATION OF AQUEOUS-BASED FILM COATING PROCESS PARAMETERS CONTAINING GLUCOSAMINE SULFATE POTASSIUM CHLORIDE
Authors: OZA NISHANT , KHODAKIYA AKRUTI , SAGAR SWATI 
Published: July 2019

Objective: The aim of the present work was to prepare film coated tablet of glucosamine sulfate potassium chloride and study the effect of coating process parameters which implicate more significant effects on an aqueous-based film coating process of tablets.
Methods: The different batches of uncoated tablets were prepared by wet granulation method. Aqueous film coating was carried out by using opadry®II white 85F18422. A 32 full factorial design was employed to study the effect of spray rate (X1) and inlet air temperature (X2) on coating uniformity, coating process efficiency and % loss on drying. The surface characteristics of the aqueous based film coated tablet were studied using a SEM. Check point batch was prepared to validate the evolved model.
Results: Preliminary trials indicated that individually process parameters affected the quality of coated tablets. Hence, studied the combined effect of these factors on the coating process required and 32 full factorial design was applied. In this study, it was seen that spray rate and inlet air temperature had a major effect on tablet coating process. It was observed from factorial batch that maximum drug release was found in batch F5.
Conclusion: The results of full factorial design indicate both parameters spray rate (X1) and inlet air temperature (X2) have significant effect on coating process and batch F5 is stable for 3 mo at accelerated condition.
FORMULATION AND CHARACTERIZATION OF HPMC AND HPMCAS BASED SOLID DISPERSIONS OF FENOFIBRATE: A COMPARATIVE STUDY
Authors: Rampal Ankit , Singh Manmeet , Mahajan Shanta , Bedi Neena 
Published: July 2019

Objective: The aim of the present study was to investigate the effect of novel polymeric carriers and to develop solid dispersion formulation that could improve in vitro profile of Fenofibrate (FB).
Methods: Spray drying technique was used to fabricate solid dispersions with hydrophilic carriers, mainly hydroxypropyl methylcellulose (HPMC) and hydroxypropyl methylcellulose acetate succinate (HPMCAS). Solid dispersions in the form of spray-dried powder were characterized with respect to the pure drug and the corresponding physical mixtures by optical microscopy, x-ray diffraction (XRD), fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC). Size and morphology of optimized solid dispersion were performed by scanning electron microscopy (SEM). Furthermore, in vitro dissolution comparisons were carried out between the optimized solid dispersion against the pure drug and the physical mixtures.
Results: Solubility studies demonstrated that the solubility of FB was not affected by pH change. The transformation of crystalline FB into an amorphous solid dispersion powder has been clearly demonstrated by optical microscopy. The molecular dispersion of drug in the dispersion matrix prepared by spray drying was confirmed in XRD and DSC studies. IR spectroscopy was observed with negligible incompatibility of the drug with polymers. Spherical morphology was observed in SEM with no evidence of FB crystals. The prepared solid dispersions exhibited dissolution improvement as compared to the pure drug and spray dried FB in 0.05 M SLS, with HPMCAS as the superior carrier over HPMC.
Conclusion: The present study vouches better in vitro profile of FB from spray-dried HPMCAS based solid dispersions.
OPTIMIZING FORMULATION OF MINI TABLETS FLOATING RANITIDINE HCL USING FULLY PREGELATINIZED STARCH (MANIHOT ESCULENTA CRANTZ) WITH SIMPLEX LATTICE DESIGN
Authors: Dewantara Putra I Gusti Ngurah Agung , MURWANTI RETNO , ROHMAN ABDUL , SULAIMAN T.N SAIFULLAH 
Published: July 2019

Objective: The main objective of this study was to optimize the noneffervescent floating mini tablets (NEFT) formula of ranitidine hydrochloride (ranitidine HCl) using the simplex lattice design (SLD) with parameters, granule flow rate, hardness, friability, floating lag time and ranitidine HCl dissolution test (%).
Methods: The material was prepared using the SLD model was cassava starch fully pregelatinized (CSFP), hydroxypropyl methylcellulose K4M (HPMC K4M), and magnesium stearate. The formula obtained was tested for critical parameters, namely flow rate, hardness, friability, floating lag time and ranitidine HCl dissolution test (%). The dissolution test was carried out by using the USP type II method (paddle method). The beaker is immersed in the water bath of temperature 37 °C. It is filled with 900 ml of 0.1 N HCl, and the apparatus was set at 75 rpm. The samples were taken in the interval of 10 min and estimated content by a spectrophotometer at 312 nm.
Results: The optimum formula based on superimposed graphs of various contour plots with SLD. From the experimental data for all test parameters, the experimental results are approaching with the results of the prediction. The condition for optimum functional components in NEFT was 80 mg for CSFP, HPMC K4M 30 mg, and 10 mg magnesium stearate to obtain a yield of 7.85 kg hardness, 0.34 % friability, 15.27 floating lag time and 91.31 % ranitidine HCl dissolved.
Conclusion: It can be concluded that the optimum formula using the Design-Expert® program the SLD concept is obtained in the range of 70-80 mg CSFP, 30-40 mg HPMC K4M, 0-10 mg magnesium stearate.
CHARGE-TRANSFER COMPLEXES OF CHLORPHENOXAMINE HYDROCHLORIDE WITH CHLORANILIC ACID, 2,3-DICHLORO-5,6-DICYANO-1,4-BENZOQUINONE AND 7,7,8,8-TETRACYANOQUINODIMETHANE AS π-ACCEPTORS
Authors: EL-DIDAMONY AKRAM M. , SAAD MOUNIR Z. , RAMADAN GEHAD M. 
Published: July 2019

Objective: To develop simplified, accurate and precise visible spectrophotometric strategies for the assay of chlorphenoxamine hydrochloride (CPX) in pure drug and in its pharmaceutical preparations.
Methods: The described methods depended on the formation of charge-transfer (CT) complexes of intense color between CPX as donor with three π-acceptors, chloranilic acid (CLA), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), and 7,7,8,8-tetracyanoquinodimethane (TCNQ) and the colored reaction products were estimated spectrophotometrically at 520 nm, 460 nm and 840 nm for CLA, DDQ, and TCNQ complexes, individually. All the optimum conditions were established. The proposed methods were validated in term of linearity, limit of detection as per the international conference on harmonization guidelines ICH Q2 (R1).
Results: The complexes obeyed Beer’s law in the concentration range of 16-144, 6-54 and 4-76 μg/mlwith molar absorptivity at 0.30×104, 0.68×104 and 0.58×104 l/mol/cm for CLA, DDQ, and TCNQ, individually. According to Benesi-Hildebrand plots, the association constants and changes of standard free energy were determined. 1:1 was the ratio of composition of the formed CT-complex.
Conclusion: The obtained results revealed that the developed method can be applied successfully for the determination of CPX in drug formulations samples with good accuracy and precision.
INFLUENCE OF DOSE AND USP DISSOLUTION APPARATUS IN THE RELEASE PERFORMANCE OF REFERENCE TABLETS: PROPRANOLOL-HCl AND RANITIDINE-HCl CASES
Authors: MEDINA-LOPEZ JOSE RAUL , CEDILLO-DIAZ LUIS ANTONIO , HURTADO MARCELA 
Published: July 2019

Objective: Due to quality of generic formulations depends on available information of reference drug products the aim of this work was to perform an in vitro dissolution study of two doses of propranolol-HCl and ranitidine-HCl reference tablets using USP basket or paddle apparatus and flow-through cell method.
Methods: Two doses of propranolol-HCl (10-mg and 80-mg) and ranitidine-HCl (150-mg and 300-mg) of Mexican reference products were used. Dissolution profiles of propranolol-HCl were obtained with USP basket apparatus at 100 rpm and 1000 ml of 1% hydrochloric acid. Profiles of ranitidine-HCl were determined with USP paddle apparatus at 50 rpm and 900 ml of distilled water. All formulations were also studied with the flow-through cell method using laminar flow at 16 ml/min. Dissolution profiles were compared by model-independent (f2 similarity factor, mean dissolution time and dissolution efficiency) and model-dependent methods (dissolution data adjusted to some mathematical equations). Time data, derived from these adjustments, as t50%, t63.25%, and t85% were used to compare dissolution profiles.
Results: With all approaches used and being high solubility drugs significant differences were found between low and high doses and between USP dissolution apparatuses (*P<0.05).
Conclusion: In vitro dissolution performance of two doses of propranolol-HCl and ranitidine-HCl was not expected. Considering the same USP dissolution apparatus, the reference tablets did not allow the simultaneous release of the used doses. The results could be of interest for pharmaceutical laboratories or health authorities that classify some drug products as a reference to be used in dissolution and bioequivalence studies.
The Effect Analysis of Reservoir Height Variations at the Pico-Hydro System to Charger a Laptop Battery
Authors: Syamsuri Syamsuri , Maulana Hasan Syafik , Kusuma Wendy Candra 
Published: July 2019

Energy has become a very serious problem in many countries, one of which is electric energy. Water is the latest energy that deserves to be developed and also utilized to the fullest. In addition to the source of our life, water is also an energy that can be utilized for a variety of things including the development of technology, such as the energy source for hydroelectric power generation such as pico hydro. An example of piko-hydro is a Pelton turbine that utilizes the flow of water from a height. Among other advantages, the power produced is large, simple construction, easy to maintain, the technology that is simple and easy to apply in isolated areas. In generating the maximum electric energy, research is conducted experimental studies of the influence of Pelton turbine head height variation of the electrical energy that is generated to turn on the laptop. The study was carried out in the ITATS H building using a variety of valve openings and head heights of 18º, 36º, 54º, 72º, 90º and 17, 12.5, and 9 meters on Pelton turbines. Based on research and data analysis, the greatest electrical power is obtained, which is 3.96 Watts at variations of the valve opening 90º and with a reservoir height of 17 meters. The maximum efficiency system achieved at the water reservoir height of the 17 meters with 90 valve openings is 14.56%. The results of the electrical power produced by this Pelton turbine can be used to charge the laptop for 2.18 hours
Cooperative Adaptive Driving for Platooning Autonomous Self Driving Based on Edge Computing
Authors: Chang Ben-Jye , Hwang Ren-Hung , Tsai Yueh-Lin , Yu Bo-Han , Liang Ying-Hsin 
Published: July 2019

Abstract
Cooperative adaptive cruise control (CACC) for human and autonomous self-driving aims to achieve active safe driving that avoids vehicle accidents or traffic jam by exchanging the road traffic information (e.g., traffic flow, traffic density, velocity variation, etc.) among neighbor vehicles. However, in CACC, the butterfly effect is encountered while exhibiting asynchronous brakes that easily lead to backward shock-waves and are difficult to remove. Several critical issues should be addressed in CACC, including (i) difficulties with adaptive steering of the inter-vehicle distances among neighbor vehicles and the vehicle speed, (ii) the butterfly effect, (iii) unstable vehicle traffic flow, etc. To address the above issues in CACC, this paper proposes the mobile edge computing-based vehicular cloud of the cooperative adaptive driving (CAD) approach to avoid shock-waves efficiently in platoon driving. Numerical results demonstrate that the CAD approach outperforms the compared techniques in the number of shock-waves, average vehicle velocity, average travel time and time to collision (TTC). Additionally, the adaptive platoon length is determined according to the traffic information gathered from the global and local clouds.
LMI–Based Robust Control of Uncertain Nonlinear Systems via Polytopes of Polynomials
Authors: Sánchez Marcelino , Bernal Miguel 
Published: July 2019

Abstract
This investigation is concerned with robust analysis and control of uncertain nonlinear systems with parametric uncertainties. In contrast to the methodologies from the field of linear parameter varying systems, which employ convex structures of the state space representation in order to perform analysis and design, the proposed approach makes use of a polytopic form of a generalisation of the characteristic polynomial, which proves to outperform former results on the subject. Moreover, the derived conditions have the advantage of being cast as linear matrix inequalities under mild assumptions.
Parameter Identification and Estimation For Stage–Structured Population Models
Authors: Coll Carmen , Sánchez Elena 
Published: July 2019

Abstract
A stage-structured population model with unknown parameters is considered. Our purpose is to study the identifiability of the model and to develop a parameter estimation procedure. First, we analyze whether the parameter vector can or cannot uniquely be determined with the knowledge of the input-output behavior of the model. Second, we analyze how the information in the experimental data is translated into the parameters of the model. Furthermore, we propose a process to improve the recursive values of the parameters when successive observation data are considered. The structure of the state matrix leads to an analysis of the inverse of a sum of rank-one matrices.
Almost Periodic Synchronization of Fuzzy Cellular Neural Networks with Time–Varying Delays via State–Feedback and Impulsive Control
Authors: Li Yongkun , Wang Huimei , Meng Xiaofang 
Published: July 2019

Abstract
In this paper, we are concerned with drive-response synchronization for a class of fuzzy cellular neural networks with time varying delays. Based on the exponential dichotomy of linear differential equations, the Banach fixed point theorem and the differential inequality technique, we obtain the existence of almost periodic solutions of this class of networks. Then, we design a state feedback and an impulsive controller, and construct a suitable Lyapunov function to study the problem of global exponential almost periodic synchronization for the drive-response systems considered. At the end of the paper, we provide an example to verify the effectiveness of the theoretical results.
Machine Learning–based Analysis of English Lateral Allophones
Authors: Piotrowska Magdalena , Korvel Gražina , Kostek Bożena , Ciszewski Tomasz , Cżyzewski Andrzej 
Published: July 2019

Abstract
Automatic classification methods, such as artificial neural networks (ANNs), the k-nearest neighbor (kNN) and self-organizing maps (SOMs), are applied to allophone analysis based on recorded speech. A list of 650 words was created for that purpose, containing positionally and/or contextually conditioned allophones. For each word, a group of 16 native and non-native speakers were audio-video recorded, from which seven native speakers’ and phonology experts’ speech was selected for analyses. For the purpose of the present study, a sub-list of 103 words containing the English alveolar lateral phoneme /l/ was compiled. The list includes ‘dark’ (velarized) allophonic realizations (which occur before a consonant or at the end of the word before silence) and 52 ‘clear’ allophonic realizations (which occur before a vowel), as well as voicing variants. The recorded signals were segmented into allophones and parametrized using a set of descriptors, originating from the MPEG 7 standard, plus dedicated time-based parameters as well as modified MFCC features proposed by the authors. Classification methods such as ANNs, the kNN and the SOM were employed to automatically detect the two types of allophones. Various sets of features were tested to achieve the best performance of the automatic methods. In the final experiment, a selected set of features was used for automatic evaluation of the pronunciation of dark /l/ by non-native speakers.
The Parallel Tiled WZ Factorization Algorithm for Multicore Architectures
Authors: Bylina Beata , Bylina Jarosław 
Published: July 2019

Abstract
The aim of this paper is to investigate dense linear algebra algorithms on shared memory multicore architectures. The design and implementation of a parallel tiled WZ factorization algorithm which can fully exploit such architectures are presented. Three parallel implementations of the algorithm are studied. The first one relies only on exploiting multithreaded BLAS (basic linear algebra subprograms) operations. The second implementation, except for BLAS operations, employs the OpenMP standard to use the loop-level parallelism. The third implementation, except for BLAS operations, employs the OpenMP task directive with the depend clause. We report the computational performance and the speedup of the parallel tiled WZ factorization algorithm on shared memory multicore architectures for dense square diagonally dominant matrices. Then we compare our parallel implementations with the respective LU factorization from a vendor implemented LAPACK library. We also analyze the numerical accuracy. Two of our implementations can be achieved with near maximal theoretical speedup implied by Amdahl’s law.
First record of spider Tegenaria ferruginea (Panzer, 1804) from Belarus with notes on overwintering
Authors: Tsiareshyna Maryia 
Published: July 2019

Abstract
First record of the spider Tegenaria ferruginea (Panzer, 1804) from Belarus, along with taxonomic diagnosis and photographs are presented. Contrary to the expectations, males and females were found during overwintering in the silken sac in the fort of Brest, Belarus.
How Important is Gambling in National GDP: Case Study from Austria, Croatia, Italy and Slovenia
Authors: Raspor Andrej , Bulatović Iva , Stranjančević Ana , Lacmanović Darko 
Published: July 2019

Abstract
Purpose – The situation in the field of gambling is changing due to the rise of Internet and Mobile gambling. In general gambling consumption is increasing every year, but the distribution of consumption has radically changed from Land Based gambling to Remote gambling. The purpose of this article is to present an overview of the world gambling industry and a specific overview in Austria, Croatia, Italy and Slovenia in order to find some main similarities and differences in observed period.
Design/Methodology/Approach – The main research question is How important is gambling for the involved countries and what proportion of the national GDP does the gambling revenue account for? This paper presents the analysis of five statistical databases for the last sixteen years in order to find out some patterns, cyclical or seasonal features or other significant information that allows us to do forecasting of the future revenue with a certain degree of accuracy. We have systematically searched and collected data from the World Bank and the National Statistical Offices websites of the given countries. Statistical methods were used for benchmark analysis, while Box and Jenkins approach and ARIMA modelling were used for forecasting.
Findings – The smallest increase was recorded in Slovenia and the largest in Italy. The same effects were also observed in the GDP of these countries. Thus, the state budgets of Croatia and Italy are increasingly dependent on gambling taxes. It also has negative wages. The gambling addictions among the locals have become more frequent as well.
Originality of the research – The article shows the forecasts of the gambling revenue and its share in the GDP by 2027. We want to alert decision makers to adopt appropriate policies. States need to rethink their views on gambling and the excessive dependence of the state budget on gambling taxes. This is the first time a single comparative analysis of these countries and the above mentioned forecast has been conducted.
Strategic Development of the Montenegrin Tourist Product in Relative to Current Market Trends
Authors: Županović Ivo , Vulević Milica 
Published: July 2019

Abstract
Adequate accommodation infrastucture is on of the basic conditions for sustainable tourism development. In order to improve accommodation infrastructure, particular addressing the problem of a large share of private accommodation in total infrastucture, it is proposed to transform these capacities indo condo model, diffused and integral hotels. Another major problem in tourism development in Montenegro is not an adequate structure of emissive markets, more precisely dominance of 2 markets. In order to improve emissive market infracture it is necessary to focus primarly on West European and Scandinavian market. Improving the situation of the mentioned problems would significaly affect the sustainable development of tourism in Montenegro.
Performance Measurement Using Development Ladder Assessment and Health Indicators: Study of Co-operatives
Authors: Ibrahim Ridwan , Deiriadi Donni , Fahlevi Heru 
Published: July 2019

AbstractObjective – This study aimed to analyze the performance of co-operative using two different performance management measures, Development Ladder Assessment (DLA 2009 version) and co-operative health indicator (CHI). Design/methodology – The sample of this study is 10 co-operatives operated in Aceh, Indonesia. Data was collected from secondary and primary sources. The secondary data is obtained from financial reports and annual meeting reports of 2014 and 2016, while primary data was collected from questionnaires with management and supervisory board of the co-operatives. The data was analyzed using a comparative and descriptive statistical approach. Results – This study found that both performance methods produced different results. Some co-operatives attain rank “A” in DLA approach, but no co-operatives are categorized as rank “A” within CHI measure. Additionally, DLA is more informative for the supervisory board in measuring co-operative performance than CHI.