bluuebunny/crossref_metadata_2025_split huggingface dataset:
Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes
Authors: Murphy Caitriona , Mullen Eithne , Hogan Karrie , O’toole ronan , Teeling Seán Paul 
Published: September 2019

Abstract

Objective
To improve access for hip fracture patients to surgery within 48 h of presentation to the Emergency Department, and to increase the number of patients receiving pre-operative orthogeriatric review, through streamlining an existing hip fracture patient pathway.

Design
A pre–post design involving a multi-disciplinary team use of the Define, Measure, Analyse, Improve and Control framework integral to Lean Six Sigma (LSS) methodology, to assess and adapt the existing hip fracture pathway from presentation to Emergency Department to the initiation of surgery.

Setting
A 600-bed teaching hospital in Ireland.

Participants
Nursing, medical, administrative and physiotherapy staff working across Emergency Medicine, Orthogeriatrics and Orthopaedic Specialities and Project management.

Interventions
LSS methodology was used to redesign an existing pathway, improving patient access to ortho-geriatrician assessment, pain relief and surgery in line with the Irish Hip Fracture Data Base Key performance indicators.

Main Outcome Measures
Access to pain relief, access to surgery and volume of patients receiving ortho-geriatric assessment.

Results
The percentage of patients undergoing surgery within 48 h of presentation to Emergency Department increased from 55% to 79% at 3 months, and to 85% at 6 months. Improvements were also achieved in the secondary performance metrics relevant to quality of patient care. All care pathway changes were cost neutral.

Conclusions
Hip fracture surgery within 48 h of presentation to hospital is a recognized standard of hip fracture care associated with decreased length of stay and decreased mortality. With respect to this performance metric, this intervention has contributed to improved patient outcomes.
A Propensity to Murder: Phrenology in Antebellum Medico-Legal Theory and Practice
Authors: Thompson Courtney E 
Published: September 2019

Abstract
This essay explores the uses of phrenological theory in the realm of jurisprudence between the mid-1830s and 1850s, focusing in particular on the adoption and circulation of phrenological language within medico-legal circles through this period. The article begins by contextualizing medical jurisprudence in early America; at the same time that phrenology was gaining ground in the United States, theories of medical jurisprudence were in flux. I next turn to the concept of the propensities in phrenological theory and their relationship to theories of moral insanity developed in the same period. This article concludes with an exploration of explicit and implicit uses of phrenology, focusing on court cases featuring phrenological expertise or language. The article thus suggests both the uses of phrenology for the building of medico-legal expertise and the extent to which phrenological language around the propensities inflected lay and medico-legal discourse around criminal responsibility and insanity.
Fumigation Activities of Methyl Benzoate and Its Derivatives Against the Common Bed Bug (Hemiptera: Cimicidae)
Authors: Larson Nicholas R , Zhang Aijun , Feldlaufer Mark F 
Published: September 2019

Abstract
Common bed bug Cimex lectularius (L.) (Hemiptera: Cimicidae) infestations are on the rise and due to the development of pesticide resistance they are becoming more difficult to control, affordably. We evaluated a naturally occurring compound methyl benzoate (MB) and related analogs, previously reported to have insecticidal activity on several agricultural pests, for its fumigant action on the common bed bug, C. lectularius L. A discriminating concentration was used to determine the effectiveness of MB, and several of its analogs as fumigants in a laboratory assay. It was found that MB provided &gt;90% control of adult bed bugs in this laboratory fumigant assay. LC50 values were calculated for MB against both a pyrethroid-susceptible and a pyrethroid-resistant strain of common bed bugs. It was determined that both strains were susceptible in this laboratory assay. However, when MB was tested in a field-like assay and compared to a commercially available bed bug control product, it was found to be significantly less effective compared to the commercial product. Our study has found that while MB has the potential to be used as a bed bug control agent, refinements in the delivery system will be needed to increase efficacy under field-like conditions.
Application of machine learning techniques to electron microscopic/spectroscopic image data analysis
Authors: Muto Shunsuke , Shiga Motoki 
Published: September 2019

Abstract
The combination of scanning transmission electron microscopy (STEM) with analytical instruments has become one of the most indispensable analytical tools in materials science. A set of microscopic image/spectral intensities collected from many sampling points in a region of interest, in which multiple physical/chemical components may be spatially and spectrally entangled, could be expected to be a rich source of information about a material. To unfold such an entangled image comprising information and spectral features into its individual pure components would necessitate the use of statistical treatment based on informatics and statistics. These computer-aided schemes or techniques are referred to as multivariate curve resolution, blind source separation or hyperspectral image analysis, depending on their application fields, and are classified as a subset of machine learning. In this review, we introduce non-negative matrix factorization, one of these unfolding techniques, to solve a wide variety of problems associated with the analysis of materials, particularly those related to STEM, electron energy-loss spectroscopy and energy-dispersive X-ray spectroscopy. This review, which commences with the description of the basic concept, the advantages and drawbacks of the technique, presents several additional strategies to overcome existing problems and their extensions to more general tensor decomposition schemes for further flexible applications are described.
Hematopoietic Stem Cell Gene Therapy for Brain Metastases Using Myeloid Cell–Specific Gene Promoters
Authors: Andreou Tereza , Rippaus Nora , Wronski Krzysztof , Williams Jennifer , Taggart David , Cherqui Stephanie , Sunderland Ashley , Kartika Yolanda D , Egnuni Teklu , Brownlie Rebecca J , Mathew Ryan K , Holmen Sheri L , Fife Christopher , Droop Alastair , Lorger Mihaela 
Published: September 2019

AbstractBackgroundBrain metastases (BrM) develop in 20–40% of cancer patients and represent an unmet clinical need. Limited access of drugs into the brain because of the blood-brain barrier is at least partially responsible for therapeutic failure, necessitating improved drug delivery systems.MethodsGreen fluorescent protein (GFP)-transduced murine and nontransduced human hematopoietic stem cells (HSCs) were administered into mice (n = 10 and 3). The HSC progeny in mouse BrM and in patient-derived BrM tissue (n = 6) was characterized by flow cytometry and immunofluorescence. Promoters driving gene expression, specifically within the BrM-infiltrating HSC progeny, were identified through differential gene-expression analysis and subsequent validation of a series of promoter-green fluorescent protein-reporter constructs in mice (n = 5). One of the promoters was used to deliver tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) to BrM in mice (n = 17/21 for TRAIL vs control group).ResultsHSC progeny (consisting mostly of macrophages) efficiently homed to macrometastases (mean [SD] = 37.6% [7.2%] of all infiltrating cells for murine HSC progeny; 27.9% mean [SD] = 27.9% [4.9%] of infiltrating CD45+ hematopoietic cells for human HSC progeny) and micrometastases in mice (19.3–53.3% of all macrophages for murine HSCs). Macrophages were also abundant in patient-derived BrM tissue (mean [SD] = 8.8% [7.8%]). Collectively, this provided a rationale to optimize the delivery of gene therapy to BrM within myeloid cells. MMP14 promoter emerged as the strongest promoter construct capable of limiting gene expression to BrM-infiltrating myeloid cells in mice. TRAIL delivered under MMP14 promoter statistically significantly prolonged survival in mice (mean [SD] = 19.0 [3.4] vs mean [SD] = 15.0 [2.0] days for TRAIL vs control group; two-sided P = .006), demonstrating therapeutic and translational potential of our approach.ConclusionsOur study establishes HSC gene therapy using a myeloid cell–specific promoter as a new strategy to target BrM. This approach, with strong translational value, has potential to overcome the blood-brain barrier, target micrometastases, and control multifocal lesions.
Comparative genomics can provide new insights into the evolutionary mechanisms and gene function in CAM plants
Authors: Yang Xiaohan , Liu Degao , Tschaplinski Timothy J , Tuskan Gerald A 
Published: September 2019

Abstract
Crassulacean acid metabolism (CAM) photosynthesis is an important biological innovation enabling plant adaptation to hot and dry environments. CAM plants feature high water-use efficiency, with potential for sustainable crop production under water-limited conditions. A deep understanding of CAM-related gene function and molecular evolution of CAM plants is critical for exploiting the potential of engineering CAM into C3 crops to enhance crop production on semi-arid or marginal agricultural lands. With the newly emerging genomics resources for multiple CAM species, progress has been made in comparative genomics studies on the molecular basis and subsequently on the evolution of CAM. Here, recent advances in CAM comparative genomics research in constitutive and facultative CAM plants are reviewed, with a focus on the analyses of DNA/protein sequences and gene expression to provide new insights into the path and driving force of CAM evolution and to identify candidate genes involved in CAM-related biological processes. Potential applications of new computational and experimental technologies (e.g. CRISPR/Cas-mediated genome-editing technology) to the comparative and evolutionary genomics research on CAM plants are offered.
When leaving is normal and staying is novel: Men’s labor migration and women’s employment in rural Mozambique
Authors: Agadjanian Victor , Hayford Sarah R. , Oh ByeongDon 
Published: September 2019

Abstract
Considerable cross-national research has examined the impact of international labor migration on livelihoods in sending households and communities. Although findings vary across contexts, the general underlying assumption of this research is that migration represents a novel income-generating alternative to local employment. While engaging with this assumption, we also argue that in many sending communities where labor migration has been going on for generations, it is the decision not to migrate and instead to pursue local livelihood opportunities that might constitute a true departure from the expected behavior. Importantly, both the decisions to migrate and not to migrate are part of a household strategy shaped by gendered negotiation and bargaining. Building on these propositions, we use rich survey data from rural Mozambique, a typical setting of long-established large-scale international male labor out-migration, to examine married women’s gainful employment outside subsistence agriculture as it relates to their husbands’ migration or local work. We find a somewhat lower likelihood of employment among migrants’ wives, compared with nonmigrants’ wives, and this pattern strengthens with increased duration of migration. However, we also find substantial differences among nonmigrants’ wives: women married to locally employed men have themselves by far the highest probability of employment, while wives of nonemployed men are no different from migrants’ wives, net of other factors. These findings are discussed in light of interconnected gendered complexities of both migration-related and local labor market constraints and choices.
Histopathological study on the prevalence of trichosporonosis in formalin-fixed and paraffin-embedded tissue autopsy sections by in situ hybridization with peptide nucleic acid probe
Authors: Sadamoto Sota , Shinozaki Minoru , Nagi Minoru , Nihonyanagi Yasuhiro , Ejima Kozue , Mitsuda Aki , Wakayama Megumi , Tochigi Naobumi , Murakami Yoshitaka , Hishima Tsunekazu , Nemoto Tetsuo , Nakamura Shigeki , Miyazaki Yoshitsugu , Shibuya Kazutoshi 
Published: September 2019

AbstractTrichosporon species are some of the most common pathogenic yeasts in Asia, and many are resistant to echinocandin antifungal drugs. Effective treatment of fungal infections requires the selection of appropriate antifungals and the accurate identification of the causal organism. However, in histopathological specimens Trichosporon spp. are often misidentified as Candida species due to morphological similarities. In situ hybridization (ISH) is a useful technique for identifying fungal species in formalin-fixed and paraffin-embedded (FFPE) tissue sections. Although many novel probes for ISH are available, the practical use of ISH for identification of fungi remains limited, in part due to the lack of adequate verifications. We conducted a two-center retrospective observational study in which the ISH technique was used to differentiate Trichosporon spp. and C. albicans in FFPE tissue from autopsy specimens. The study included 88 cases with blood stream yeast infection without Cryptococci extracted from 459 autopsy files of cases with proven invasive fungal infection (IFI). Positive signals for the Trichosporon spp. protein nucleic acid (PNA) probe and C. albicans PNA probe were seen for 7 and 35 cases, respectively, whereas the remaining 46 were negative for both. For the Trichosporon spp.- positive specimens, 5/7 were reported as candidiasis in autopsy records. Our results suggested that accurate histological identification of fungal infections remains challenging, but ISH may be a suitable approach to support histological findings. In addition, this retrospective study suggested that trichosporonosis may have high prevalence among cases of bloodstream yeast infections in Japan.
Origin of the galaxy H i size–mass relation
Authors: Stevens Adam R H , Diemer Benedikt , Lagos Claudia del P , Nelson Dylan , Obreschkow Danail , Wang Jing , Marinacci Federico 
Published: September 2019

ABSTRACT
We analytically derive the observed size–mass relation of galaxies’ atomic hydrogen (H i), including limits on its scatter, based on simple assumptions about the structure of H i discs. We trial three generic profiles for H i surface density as a function of radius. First, we assert that H i surface densities saturate at a variable threshold, and otherwise fall off exponentially with radius or, secondly, radius squared. Our third model assumes the total gas surface density is exponential, with the H i fraction at each radius depending on local pressure. These are tested against a compilation of 110 galaxies from the THINGS, LITTLE THINGS, LVHIS, and Bluedisk surveys, whose H i surface density profiles are well resolved. All models fit the observations well and predict consistent size–mass relations. Using an analytical argument, we explain why processes that cause gas disc truncation – such as ram-pressure stripping – scarcely affect the H i size–mass relation. This is tested with the IllustrisTNG(100) cosmological, hydrodynamic simulation and the Dark Sage semi-analytic model of galaxy formation, both of which capture radially resolved disc structure. For galaxies with $m_* \ge 10^9\, {\rm M}_{\odot }$ and $m_{\rm H\, {\small {I}}} \ge 10^8\, {\rm M}_{\odot }$, both simulations predict H i size–mass relations that align with observations, show no difference between central and satellite galaxies, and show only a minor, second-order dependence on host halo mass for satellites. Ultimately, the universally tight H i size–mass relation is mathematically inevitable and robust. Only by completely disrupting the structure of H i discs, e.g. through overly powerful feedback, could a simulation predict the relation poorly.
The nature of faint radio galaxies at high redshifts
Authors: Saxena A , Röttgering H J A , Duncan K J , Hill G J , Best P N , Indahl B L , Marinello M , Overzier R A , Pentericci L , Prandoni I , Dannerbauer H , Barrena R 
Published: September 2019

ABSTRACT
We present spectra and near-infrared images of a sample of faint radio sources initially selected as promising high-redshift radio galaxy (HzRG) candidates. We have determined redshifts for a total of 13 radio galaxies with redshifts ranging from 0.52 ≤ $z$ ≤ 5.72. Our sample probes radio luminosities that are almost an order of magnitude fainter than previous large samples at the highest redshifts. We use near-infrared photometry for a subsample of these galaxies to calculate stellar masses using simple stellar population models, and find stellar masses to be in the range $10^{10.8} {--}10^{11.7} \, \mathrm{M}_\odot$. We then compare our faint radio galaxies with brighter radio galaxies at $z$ ≥ 2 from the literature. We find that fainter radio galaxies have lower Ly α luminosities and narrower line widths compared to the bright ones, implying photoionization by a weaker active galactic nucleus (AGN). We also rule out the presence of strong shocks in faint HzRGs. The stellar masses determined for faint HzRGs are lower than those observed for brighter ones. We find that faint HzRG population in the redshift range 2–4 forms a bridge between star-forming and narrow-line AGNs, whereas the ones at $z$ &gt; 4 are likely to be dominated by star formation, and may be building up their stellar mass through cold accretion of gas. Finally, we show that the overall redshift evolution of radio sizes at $z$ &gt; 2 is fully compatible with increased inverse Compton scattering losses at high redshifts.
Dynamical friction in slab geometries and accretion discs
Authors: Vicente Rodrigo , Cardoso Vitor , Zilhão Miguel 
Published: September 2019

ABSTRACT
The evolution of planets, stars, and even galaxies is driven, to a large extent, by dynamical friction of gravitational origin. There is now a good understanding of the friction produced by extended media, either collisionless or fluid-like. However, the physics of accretion or protoplanetary discs, for instance, is described by slab-like geometries instead, compact in one spatial direction. Here, we find, for the first time, the gravitational wake due to a massive perturber moving through a slab-like medium, describing e.g. accretion discs with sharp transitions. We show that dynamical friction in such environments can be substantially reduced relatively to spatially extended profiles. Finally, we provide simple and accurate expressions for the gravitational drag force felt by the perturber, in both the subsonic and supersonic regime.
PL3.2 Trabectedin for recurrent WHO grade II or III meningioma: a randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG)
Authors: Preusser M , Silvani A , Le Rhun E , Soffietti R , Lombardi G , Sepulveda J , Brandal P , Beaney R , Bonneville-Levard A , Lorgis V , Bromberg J , Erridge S , Cameron A , Marosi C , Golfinopoulos V , Gorlia T , Weller M , Wick W 
Published: September 2019

Abstract

BACKGROUND
EORTC-1320-BTG investigated the activity, safety and quality of life of therapy with the tetrahydroisoquinoline alkaloid trabectedin (Yondelis®) in patients with recurrent higher-grade meningiomas. Trabectedin was originally derived from the Caribbean sea squirt, Ecteinascidia turbinata, and currently is manufactured by total synthesis.

METHODS
Adult patients with histological diagnosis of WHO grade II or III meningioma and radiologically documented progression after maximal feasible surgery and radiotherapy were randomly assigned in a 2:1 ratio to receive intravenous trabectedin (1.5 mg/m2every three weeks) or local standard of care (LOC). The primary endpoint was progression-free survival (PFS).

RESULTS
Within 22.1 months, we randomized a total of 90 patients (n=29 in LOC arm, n=61 in trabectedin arm) in 35 institutions and nine countries. In the LOC arm, the following treatments were administered: hydroxyurea (n=11), bevacizumab (n=9), none (n=4), chemotherapy (n=3), somatostatin analogue (n=1), combined chemotherapy and somatostatin analogue (n=1). With 71 PFS events, median PFS was 4.17 months in the LOC and 2.43 months in the trabectedin arm (hazard ratio [HR] for progression, 1.42; 80% CI, 1.00–2.03; p=0.204) with a PFS-6 rate of 29.1% (95% CI, 11.9%-48.8%) in the LOC and 21.1% (95% CI, 11.3%-32.9%) in the trabectedin arm. Median OS was 10.61 months in the LOC and 11.37 months in the trabectedin arm (HR for death, 0.98; 95% CI, 0.54–1.76; p=0.94).Grade 3 to 5 adverse events occurred in 44.4% (18.5% related, 4 serious adverse events, 0 lethal events) of the patients in the LOC and 59% (32.8% related, 57 serious adverse events and 2 toxic deaths) of patient in the trabectedin arm.

CONCLUSIONS
In this first prospective randomized trial performed in recurrent grade II or III meningioma, trabectedin did not improve PFS and OS and was associated with significantly higher toxicity as compared to LOC treatment. The data collected in this study may serve as benchmark for future clinical trials in this setting.
PL3.5 Efficacy and safety of selinexor in recurrent glioblastoma
Authors: Lassman A B , Wen P Y , van den Bent M , Plotkin S R , Walenkamp A , Green A , Huang X , Karla Rodriguez-Lopez K , Kauffman M G , Shacham S , Mau-Soerensen M 
Published: September 2019

Abstract

BACKGROUND
New treatment modalities are needed for recurrent glioblastoma (rGBM). Selinexor is a novel, oral selective inhibitor of nuclear export which forces nuclear retention of tumor suppressor proteins including p53 and p27, leading to apoptosis. We previously reported interim results showing tolerability, preliminary efficacy, and blood-brain barrier penetration in a surgical cohort (N=8). We now report updated results following completion of accrual to non-surgical cohorts (N=68).

MATERIALS AND METHODS
This is an open-label, multicenter, phase 2 study of selinexor monotherapy. Patients (pts) not undergoing surgery for measurable rGBM per response assessment neuro-oncology criteria (RANO) were enrolled in one of 3 arms encompassing different dosing schedules of selinexor (50 mg/m2 [~ 85 mg] BIW, 60 mg BIW, and 80 mg QW). Treatment was continuous, although cycles were defined as 28 days and response was assessed every other cycle by MRI. Prior treatment with radiotherapy and temozolomide was required and prior bevacizumab was exclusionary. The primary endpoint was 6-month progression free survival (6mPFS) rate, calculated by the Kaplan-Meier method.

RESULTS
76 pts were enrolled; 24, 14 and 30 pts on doses of ~85 mg BIW, 60 mg BIW, and 80 mg QW, respectively. Median age was 56 years (range 21–78). Median number of prior treatments was 2 (range 1–7)
At the end of the 6 cycles, 30.2% pts on 80 mg QW were free from progression. The 6mPFS rate on 80 mg QW was 18.9%. Best RANO-defined responses (assessed locally) among 26 evaluable pts on 80 mg QW included 1 complete response, 2 partial responses, 7 stable disease, and 16 with progressive disease. Complete and partial responses were durable: the complete and a partial responder remain on selinexor for 393 and 1093 days respectively, as of the cut-off date. Median duration of response was 10.8 months. The most common related adverse events (all grades) in pts on ~85 mg BIW/60 mg BIW/80 mg QW were nausea (42%/64%/63%), leukopenia (38%/7%/43%), fatigue (71%/71%/47%), neutropenia (29%/14%/33%), decreased appetite (46%/71%/27%), and thrombocytopenia (67%/29%/23%).

CONCLUSION
Selinexor demonstrated efficacy, with durable responses and disease stabilization in rGBM. Based on the favorable efficacy and safety profile, selinexor at a dose of 80 mg QW is recommended for further development in rGBM.