bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life-threatening conditions in pericarditis of different etiologies: diagnosis and treatment
Authors: Kosonogov A. Ya. , Nemirova S. V. , Pozdishev V. I. , Nikolskiy A. B. , Kosonogov K. A. , Ribinckiy A. D. , Sidorov M. A. , Loginova S. V. 
Published: June 2019

Purpose of the study: to analyze the etiology, diagnostic criteria and results of treatment of life-threatening conditions in pericarditis of different etiologies (based on our clinic materials).Materials and methods. The study included cases of hospitalization of patients with a diagnosis of «Pericarditis» and ICD-10 codes for pericardial diseases for the period from 2009 to 2018. In the course of the work, the history and clinical picture of the disease, laboratory and radiation research methods were analyzed. All patients started treatment of the underlying disease and performed symptomatic therapy, including those aimed at restoring hemodynamics and normalizing water and electrolyte disorders, stopping inflammation and auto-aggression of the immune system. When signs of compression/cardiac tamponade were detected, pericardiocentesis was performed, according to indications, drainage/fenestration of the cardiac sac, pericardiotomy were performed. In the postoperative period was carried out antibacterial and symptomatic therapy.Results. Life-threatening diseases of the pericardium accounted for 32,03% of all patients treated in the hospital for pericarditis. The most frequently detected signs of a hemodynamically significant compression and cardiac tamponade, less often purulent and constrictive P. Isolated 25 patients underwent closed drainage with pericardiocentesis, in 1 case the drainage was supplemented with f ibrinolytic therapy. Sanitation of the cavity and fenestration of the pericardium were carried out in 11 patients, pericardiotomy with notched drainage in 2 patients, thoracotomy with pericardiectomy – 4. In the postoperative period, the symptoms of inflammation were reduced, the level of cardiac enzymes decreased, the electrolyte balance stabilized. Most patients noted a distinct regression of the symptoms of pericarditis and cardiac compression. Recurrent P was noted in 5 cases, deaths occurred in 4 cases (8,16%).Conclusion. Early verification of the diagnosis and timely decompression of the heart with fractional evacuation of the exudate or pericardectomy with respect to the sequence of release of the heart chambers from adhesions and adhesions against the background of complex therapy allows to achieve positive dynamics, and fenestration of the cardiac bag with the formation of a sufficiently sized opening during recurrent fluid accumulation or intrapericardial fibrin. development of severe complications of pericarditis even in patients with multiple concomitant diseases evanii and oncopathology.
Treatment of recurrent Wilms tumor: a 10-year experience of a single center in Southern China
Authors: Jiang Hong , Gao Pengfei , Chen Huadong , Zhong Zhihai , Zhang Zhichong , She Jinbiao , Liu Juncheng 
Published: June 2019

Abstract
Background: This study aimed to report our 10-year experiences on the treatment of recurrent Wilms tumor (WT) to improve the therapeutic outcome of recurrent WT in China. Patients and Methods: From August 2006 to August 2017, 14 patients (7 males and 7 females) with recurrent Wilms’ tumor treated at our center were included. Their medical records were reviewed.
Results: Primary WT were mainly diagnosed at the age of 1-3 years (50%). The main histology of primary WT was unclassified types (42.9%), followed by blastemal types (35.7%). Four cases did not receive standardized postoperative chemotherapy after the initial surgery. Recurrence mostly occurred within the first year after initial surgery (57.1%). The recurrent WT mainly occurred at the primary location and ipsilateral lymph nodes (35.7%), followed by extensive peritoneal metastasis (28.6%). Eleven patients underwent surgery for complete resection of the recurrent lesions. There were 9 patients achieved event-free survival for 1 year 2 months to 9 years. Three, one, one and one patients died of extensive intraperitoneal metastases, brain metastasis, peritoneal metastasis, severe intestinal obstruction vomiting, electrolyte imbalance and tumor invasion of the spinal cord, respectively.
Conclusions: Individualized multimodal treatment can effectively improve long-term survival of the patients of recurrence WT.
Choroidal thickness, ganglion cell complex and photoreceptor outer segment length evaluation in patients receiving tamoxifen therapy by spectral domain optical coherence tomography
Authors: Bolukbasi Selim , Gursel Ozge Kandemir , Cakir Akin , Erden Burak , Karatas Gamze 
Published: June 2019

Abstract
Background

To evaluate choroidal thickness, ganglion cell complex and photoreceptor outer segment length in patients with breast cancer undergoing tamoxifen therapy using spectral domain optical coherence tomography (SD-OCT) and to compare the results to normal eyes.

Methods

Fourty four patients with breast cancer undergoing tamoxifen therapy and fourty one healthy controls were included in this prospective, comparative study. All participants underwent a complete ophthalmologic evaluation and SD-OCT. Subfoveal, nasal (nasal distance to fovea 500 μm, 1000 μm, 1500 μm) and temporal (temporal distance to fovea 500 μm, 1000 μm, 1500 μm) choroidal thickness measurements were performed using enhanced depth imaging mode of SD-OCT. Using an Early Treatment Diagnostic Retinopathy Study (ETDRS) circle at the macular level, the automated retinal segmentation software was applied to determine thicknesses of the ganglion cell complex (GCC) by adding the macular retinal nerve fiber layer, macular ganglion cell layer, and macular internal plexiform layer parameters. The photoreceptor outer segment (PROS) length was determined by manually as the distance from inner surface of ellipsoid zone to inner surface of retina pigment epithelium after automatic retinal segmentation.

Results

The mean choroidal thickness measurements were statistically greater in tamoxifen group than controls in all quadrants (p<0.001 for all quadrants). Of all tamoxifen users (44 eyes of 44 patients), 33 eyes (75%) had uncomplicated pachychoroid (UCP). Pachychoroid pigment epitheliopathy (PPE) was detected in 5 patients (11.3%) in tamoxifen group. Patients with PPE in one eye had UCP in the fellow eye. Central serous chorioretinopathy findings were observed in one patient. Tamoxifen users had statistically lower GCC thicknesses in all inner rings of ETDRS inlay and only in nasal outer ring (p:0.027, p:0.002, p:0.002, p:0.001 and p:0.030; respectively). No statistically significant difference was found between the groups in terms of mean subfoveal PROS length.

Conclusions

SD-OCT provides valuable information in identifying the structural changes and evaluation of ocular findings in patients receiving tamoxifen therapy. Increasing choroidal thickness, PPE, thinning GCC were detected in tamoxifen users. These OCT findings may be an early indicator of retinal toxicity for patients undergoing tamoxifen therapy in follow-up period.
Protective effects of quercetin in a rodent model of anterior ischemic optic neuropathy (rAION)
Authors: Lyu Ya-nan , Min Jing-yu , Gong Yuanyuan , Gu qing , Wei fang 
Published: June 2019

Abstract
Background: Anterior ischemic optic neuropathy (AION) is the leading cause of sudden optic nerve-related (ON-related) vision loss in elderly people. However, no considerable treatments are available for the neuroprotection of NAION. The purpose of this study was to detect the effects of intravitreal injection of quercetin (Qcn) in a rodent model of anterior ischemic optic neuropathy (rAION).
Methods: The rAION model was established using verteporfin and laser in a photodynamic procedure on the optic discs (ON) of rats. The rats received intravitreal injection of Qcn 2 days before the injury and once/week for 4 weeks after the infarct on optic neuropathy. Flash-visual evoked potential (VEP) were recorded to assess the visual function. TUNEL and retrograde Fluorogold labeling assessed the apoptosis and density of retinal ganglion cells (RGCs). ED-1 and Iba-1 staining of the optic nerves displayed the inflammatory response.
Results: At 14 days post-infarct, Qcn treatment significantly reduced the number of apoptotic RGCs, as well as, ED1/Iba-1-positive cells/high power field(HPF) in the ON (p<0.01) as compared to the rAION group. At week 4 after rAION, 28.4% VEP amplitudes were estimated in the treated eyes of the fellow eyes in the rAION group and 64.7% in the rAION+Qcn group (p<0.01). In addition, Qcn saved the RGCs in the central retinas as compared to those of the rAION group (1967.5±162.1 and 2868±325.3 mm2, respectively (p<0.01), and the corresponding densities were 1654.8±104.8 and 2208±272.9 mm2 in the mid-peripheral retinas, respectively (p<0.01).
Conclusion: The intravitreal injection of Qcn could protect the RGCs from injury in the rAION animal model, as demonstrated anatomically by RGC density and functionally by F-VEP. Moreover, Qcn might exert an anti-apoptosis role in the survival of RGCs and anti-inflammatory in the optic nerves.
Integrative analysis of microRNA and mRNA expression in response to salt stress by UMI
Authors: Zhan Jing jing , Diao Yang yang , Zhao Yan yan , Li Chao , Han Xiao , Huang Long yu , sajjad muhammad , Wang Peng , Liu Li sen , Yan Qing di , Wei Xi , Ding Yan peng , Chu Yu , Ge xiao yang 
Published: June 2019

Abstract
Background

Small RNAs play an important role in regulating plant responses to abiotic stress through modulation of the processing, stability, and translation of larger RNAs. Plants employ complex mechanisms of gene regulation to respond to salinity stress.

Results

In this study, we constructed 12 small RNA libraries, 12 mRNA libraries, and a degradome library to systematically investigate the miRNAs response to salt stress. A total of 312 cotton miRNAs were identiﬁed and of these, 80 were known ghr-miRNAs. 144 genes showed significant differential expression under salt stress combined with the targeting relationship between the sRNA data and mRNA data. We found 56 miRNA-mRNA pairs which were positively correlated, and 91 pairs which were negatively correlated. Using degradome sequencing, 72 target genes were identified associated with 25 miRNA families. Gene ontology and KEGG analysis indicated some targets were involved in vital biological pathways of salinity stress tolerance: 14 were involved in responses to abiotic stress, two were associated with an environmental adaptation pathway, and a total of 16 NAC and MYB family transcription factors were related to salinity stress.

Conclusions

The present study identified a large number of cotton miRNAs and identified relationships between miRNA and mRNA, with function annotation revealing their possible biological roles in response to salt stress. Our findings will further functional studies of cotton miRNAs and the salt tolerance mechanism.
Association between periodontal disease and coronary heart disease risk in Chinese population: evidence from a meta-analysis
Authors: Cai Qing-wei , Ren Lin , Chen Rui-xin , Zou Yang , Fu Qiang , Ma Yuan-yuan 
Published: June 2019

Abstract
Aims

More and more research is focused on studying the relationship of periodontal disease with susceptibility to coronary heart disease (CHD), among which discrepancies have risen. The current study aimed to evaluate the possible relationship about periodontal disease and CHD in certain Chinese population.

Methods

The PubMed, Embase, Web of Science, the Cochrane Library, the Chinese Biomedical Database, and the Chinese National Knowledge Infrastructure were searched up to December 2018. The overall and subgroup analyses were performed using fixed or random-effect model depending on heterogeneity.

Results

A total of 2241 CHD cases and 2160 in 15 studies were used in the current study. Overall, a significantly elevated relationship about periodontal disease on CHD risk was found in all included Chinese subjects (OR=3.04, 95% CI, 2.37-3.92). Subgroup analyses by geographic location and sources of control were also performed; all the results in subgroup analyses were consistent with the overall result. Meanwhile, the significant association was found among the measures of periodontal disease with attachment loss, periodontal index, two or more clinical indications, and gum recession as well as CHD assessment method with WHO criteria and coronary arteriongraphy.

Conclusions

Collectively, the meta-analysis indicated that periodontal disease was capable of causing CHD susceptibility among Chinese.
Giant prolactinomas: experience of a single tertiary center in Mexico
Authors: Victoria Tania Raisha Torres , Pérez-Guzmán Mireya Citlalli , Vega-Beyhart Arturo , Coronel-Manzo Diego Armando , Martínez-Sánchez Froyland David , Pedroza Luis Tamez , Rubio Angelica Manrique , Hinojosa-Amaya José Miguel , Velarde Arturo Peña , Suarez Andres Leon , Gómez-Sámano Miguel Angel , Gomez-Perez Francisco Javier , Cuevas-Ramos Daniel 
Published: June 2019

Abstract
Background: Giant prolactinomas are rare tumors representing only 0.5-4.4% of pituitary adenomas, and 2-3% of prolactin secreting tumors. Clinical presentation is similar than smaller prolactinomas. However, due to the large adenoma size (≥4 cm), the normalization of prolactin levels and reduction of the tumor volume becomes a significant therapeutic challenge and multimodal treatment might be necessary.
Methods: Comparative, cross-sectional, observational, retrolective cohort, from January 1988 to December 2017. We included all patients with hyperprolactinemia, those with non-tumoral etiologies were eliminated. Our final sample consisted of 327 patients with prolactinomas. We classified them according to tumor diameter using magnetic resonance imaging (MRI), in microprolactinomas (<10mm), macroprolactinomas (≥10 mm) and giant prolactinomas with a diameter of ≥4 cm, together with prolactin level > 1000 ng/dl, and no concomitant growth hormone (GH) or adrenocorticotropic hormone (ACTH) secretion.
Results: 244 (74.6%) cases had a microprolactinoma, 72 (22%) had a macroprolactinoma, and 11 patients (3.4%) met the selection criteria for giant prolactinomas (9 males). The most common presenting features included headache, impaired vision, and erectile dysfunction. The main hormone deficiency found in men was testosterone (77.8%), followed by Thyroid-stimulating Hormone (TSH) (63%). Mean prolactin (PRL) at presentation was 2,000 ng/mL (IC 95% 1727 - 4374). All patients were treated with dopamine agonists (DA), and only 3 (27%) patients required surgery. Tumor shrinkage for giant prolactinomas with dopamine agonist was 63% on average. All patients had improved visual field defects. Since patients responded well to DA, none required further treatment modalities.
Conclusions: Giant prolactinomas are rare tumors with a male predominance. Dopamine agonists are a useful therapeutic strategy, and good response is seen with a similar average dose to those used in smaller prolactinomas. None of our patients required further medical treatment modalities although surgical debulking sometimes is necessary.
Facilitating trial recruitment: A qualitative study of patient and staff experiences of an orthopaedic trauma trial
Authors: Phelps Emma , Tutton Elizabeth , Griffin Xavier , Baird Janis 
Published: June 2019

Abstract
Background

Qualitative research has been used to explore patients’ and healthcare professionals’ experiences of surgical randomised controlled trials (RCTs). From this research, reasons why patients accept or decline participation and barriers to engaging clinicians in trials have been identified. In a trauma setting, recruitment to surgical trials can be particularly difficult as patients may require urgent treatment and their ability to consider their options, ask questions and reach a decision may be hindered by the impact of their injury. Little research however, has explored patients’ and healthcare professionals’ experiences of surgical RCTs in a trauma setting. This study aimed to understand participants’ and staffs’ experiences of an orthopaedic trauma trial.

Methods

We carried out semi-structured interviews with 11 participants and 24 staff (10 surgeons and 14 research associates) participating in a UK multi-centre feasibility trial comparing intramedullary nails versus distal locking plates for fractures of the distal femur (TrAFFix). Interviews explored patients’ experience of TrAFFix and their reason for participating and staffs’ experience of recruiting to TrAFFix and trauma trials more generally. Interviews were audio recorded and transcribed verbatim. Transcripts were analysed using thematic analysis.

Results

Three themes were identified. These were i) navigating research with patients after orthopaedic trauma, ii) knowing that it is the right decision and iii) making it work. These themes reflect: i) how research associates supported and guided patients through the consent process enabling them to participate, ii) the difficulty in engaging surgeons in a trial when individual equipoise and experience of the interventions is low despite the presence of community equipoise and iii) the way in which research teams worked together and encouraged the development of a research culture within the clinical teams in order to facilitate recruitment.

Conclusions

Our findings highlight the pivotal role of research associates (RAs) in facilitating trial recruitment. RAs supported patients to enable them to make a decision about participation and assisted in developing a research culture within the team by promoting studies and communicating research to clinical staff. Our findings also reinforce surgeons’ difficulty with equipoise and suggest that accepting community equipoise could facilitate recruitment.
Pesticide detection by a miniature microbial fuel cell under controlled operational disturbances
Authors: Chouler Jon , Di Lorenzo Mirella 
Published: June 2019

Abstract
Microbial fuel cell (MFC) technology holds enormous potential for inexpensive real-time and onsite testing of water sources. With the intent of defining optimal operational conditions, we investigated the effect of environmental factors (changes in temperature, pH and ionic strength), on the performance of a single chamber miniature MFC sensor. The pH of the influent had the greatest effect on the MFC performance, with a 0.531 ± 0.064 μA cm−2 current variation per unit change of pH. Within the range tested, temperature and ionic strength had only a minor impact (0.010 ± 0.001 μA °C−1 cm−2 and of 0.027 ± 0.003 μA mS−1 cm cm−2 respectively). Under controlled operational conditions, for the first time, we demonstrated the ability of this biosensor to detect one of the most commonly applied pesticides worldwide, atrazine. The sensitivity to atrazine was 1.39 ± 0.26 ppm−1 cm−2, with a detection range of 0.05–0.3 ppm. Guidelines for systematic studies of MFC biosensors for practical applications through a factorial design approach are also provided. Consequently, our work not only enforces the promise of miniature MFC biosensors for organic pollutants detection in waters, but it also provides important directions towards future investigations for infield applications.
Updated Studies on the Development of HIV Therapeutic Vaccine
Authors: Larijani Mona Sadat , Ramezani Amitis , Sadat Seyed Mehdi 
Published: June 2019

Background:
Among the various types of pharmaceuticals, vaccines have a special place.
However, in the case of HIV, nearly after 40 years of its discovery, an effective vaccine still is not
available. The reason lies in several facts mainly the variability and smartness of HIV as well as the
complexity of the interaction between HIV and immune responses. A robust, effective, and longterm
immunity is undoubtedly what a successful preventive vaccine should induce in order to prevent
the infection of HIV. Failure of human trials to this end has led to the idea of developing therapeutic
vaccines with the purpose of curing already infected patients by boosting their immune responses
against the virus. Nevertheless, the exceptional ability of the virus to escape the immune
system based on the genetically diverse envelope and variable protein products have made it difficult
to achieve an efficient therapeutic vaccine.

Objective:
We aimed at studying and comparing different approaches to HIV therapeutic vaccines.

Methods:
In this review, we summarized the human trials undergoing on HIV therapeutic vaccination
which are registered in the U.S. clinical trial database (clinicaltrials.gov). These attempts are divided
into different tables, according to the type of formulation and application in order to classify
and compare their results.

Result/Conclusion:
Among several methods applied in studied clinical trials which are mainly divided
into DNA, Protein, Peptide, Viral vectors, and Dendritic cell-based vaccines, protein vaccine
strategy is based on Tat protein-induced anti-Tat Abs in 79% HIV patients. However, the studies
need to be continued to achieve a durable efficient immune response against HIV-1.
An Efficient and Green Microwave-Assisted Synthesis of Quinoline DerivativesviaKnoevengal Condensation
Authors: Tasqeeruddin Syed , Asiri Yahya , Alsherhri Jaber Abdullah 
Published: June 2019

:We have developed an efficient and green synthesis of quinoline derivatives using L-proline under Knoevenagel condensation. L-proline was found to be an efficient catalyst for the Knoevenagel condensation of substituted 2-aminoaryl ketones 1 with the active methylene compounds 2, affording quinolone derivatives 3. The reaction has been done under conventional as well as under microwave conditions. The latter procedure has been found to be much more efficient in terms of time and yield.
Synthesis of Thiazole, Thiophene, Pyran and Pyridine Derivatives Derived from 3-phenyl-1H-pyrazol-5(4H)-one with Anti-proliferative, Tyrosine Kinase and PIM-1 Kinase Inhibitions
Authors: Mohareb Rafat Milad , Mikhail Ibram Refat 
Published: June 2019

Background:
A wide range of pyrazole derivatives gained special attention due to their
wide range of pharmacological activities especially the therapeutic activities. Many pharmacological
drugs containing the pyrazole nucleus are known in the market.

Methods:
The 3-phenyl-1H-pyrazol-5(4H)-one was the key starting compound for many heterocyclic
reactions to produce substituted and fused pyrazole derivatives.

Results:
Antiproliferative activities of the produced compounds against six cancer cell lines A549,
HT-29, MKN-45, U87MG, and SMMC-7721 and H460 were measured through which compounds
showed high inhibitions. The most promising compounds were tested against tyrosine kinases (c-Kit,
Flt-3, VEGFR-2, EGFR, and PDGFR). Structure-Activity Relationship (SAR) was rationalized by
looking at the varying structural features of the molecules. In addition, the most active compounds
were selected for Pim-1 inhibition.

Conclusion:
Thirty-nine pyrazole derivatives were synthesized. Nine of them 8b, 9, 12b, 12d, 14b,
15b, 18d, 18f, 19b, and 21d were the most active compounds toward the selected cancer cell lines.
Compounds 12b, 14b, 18d, 18f, and 21d showed high inhibitions toward the tyrosine kinases,
whereas compounds 14b, 18d, and 18f were the most potent inhibitors of Pim-1.