bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain Scoring in Uterine Evacuation for Incomplete Abortion Using Isolated Paracervical Block vs Combined Paracervical and Intrauterine Lignocaine Instillation: A Randomized Clinical Trial
Authors: ElRabat Mohab Ahmed Fouad , Sammour Hazem Mohamed , Sweed Mohamed Samir , ELsersi Mayar Hassan , Oraby Aya Sameh AbdelRazek , Eltaieb E 
Published: November 2024

Abstract

Background
Nerve block is a technique whereby local anesthetic solutions are infiltrated around a nerve (or perineurally) to provide anesthesia and analgesia. Nerve block for intraoperative and postoperative pain management is associated with improved analgesia, fewer opioid-related adverse events, earlier ambulation and shorter hospital stay when compared to intravenous opioid analgesia alone.

Objective
To compare efficacy of paracervical block alone versus combined paracervical block and intrauterine lidocaine installation in pain management of first trimesteric incomplete abortion.

Patients and Methods
A total of 80 women with first trimesteric incomplete miscarriage were admitted to the emergency department for uterine evacuation at Ain Shams University Maternity Hospital, in the period from September 2021 to September 2023 and underwent uterine evacuation using either paracervical block or combined paracervical block and intrauterine lidocaine instillation then pain score was obtained using visual analogue scale. Pain score was done 10 minutes after injection of local anaesthetic, 5 minutes after starting procedure and 1 hour postevacuation.

Results
It also showed that there was no statistically significant difference between both groups regarding need of opioids and time interval till opioids need. Exploring other factors that might have affected the success or failure of procedure in the study population it was found that age, parity were significant predictors such that the younger the age, the less the parity the more likely failure of procedure. Also being previous section was linked more to success than failure.

Conclusion
The combination of intrauterine lidocaine and paracervical block has no additive effect on conventional paracervical block in reducing the pain during uterine evacuation for incomplete abortion, but successful evacuation resulted in lower pain score and reduced needs for opioid.
Evaluation of El-Demerdash Maternity Hospital Experience in Management of Pregnant Women Diagnosed with Placenta Previa
Authors: Mohamed Hend A , Hassanin Alaa S , El Safty Mohammed S , Elshahawy Hazim F 
Published: November 2024

Abstract

Background
Placenta previa is a potentially dangerous condition that can affect pregnant women, leading to significant maternal morbidity and adverse perinatal outcomes.

Aim of the Work
Evaluation of placenta previa management, study of maternal and perinatal outcomes in cases of placenta previa, and study of risk factors for placenta previa.

Patients and Methods
The study included 80 women with placenta previa who were diagnosed and managed at El-Demerdash Maternity Hospital.

Results
The sociodemographic characteristics of the included patients showed a preponderance of the ages above 30 years, multiparity, history of previous cesarean section, and history of uterine scarring. Maternal outcomes showed a reasonable decrease in the hemoglobin level postoperatively compared with preoperatively. However, there was a high incidence of blood transfusion. There was an overabundance of general anesthesia performance during surgical intervention. The majority of the placenta previa patients had cesarean delivery; however, there was a low incidence of maternal surgical injuries and mortality. Regarding neonatal outcomes, most of the neonates belonged to the preterm group. The neonatal intensive care unit (NICU) admission was reported in nearly half of the included patients, attributed to preterm, respiratory distress (RD), and intrauterine growth restriction (IUGR). There was a low incidence of perinatal mortality.

Conclusion
In El-Demerdash Maternity Hospital, risk factors for placenta previa were age above 30 years, multiparity, history of previous cesarean section, and history of uterine scarring. Most placenta previa patients received conservative surgical management rather than cesarean hysterectomy. Despite the higher rate of conservative surgical management compared to cesarean hysterectomy, maternal surgical morbidity and mortality were low. However, there was a higher frequency of blood transfusion to manage postpartum hemorrhage. Most of the neonates were preterm, and neonatal intensive care unit admission was reported in nearly half of the included patients. There was a low incidence of perinatal mortality.
A Retrospective Analysis of Epidemiology and Clinical Outcomes of Patients with Epithelial Ovarian Tumors Treated in Ain Shams Clinical Oncology Department in the Period from 2017 Till 2020. Ain Shams Clinical Oncology Registry (ASCOR)
Authors: Ahmed Nahla Hamdy El Sayed , Azmi Ali Mohamed , Mosalam Nesreen Ahmed , Farag EL Ghamry Wessam Reda , El Aziz Ahmed Hassan Abd , Wahba Christine Reda 
Published: November 2024

Abstract

Background
OC is the 3rd most commonly diagnosed gynecological malignancy and ranked 2nd most common cause of gynecological malignancies deaths. In our study we reviewed medical records of 97 patients including demographic data and clinico-pathological factors; which include age, performance status, histological subtypes, histological grading, optimal surgery, CA 125 level at presentation and relation with macroscopic residual, number, types, setting and lines of chemotherapy, survival rates were calculated to evaluate them as prognostic factors.

Aim of the Work
to analyze Retrospectively Epidemiological, Risk factors and Clinical Outcomes of Epithelial Ovarian Cancer Patients Treated in Ain Shams University Hospitals in Egypt in the Period From 2017 till 2020.

Patients and Methods
At the department of clinical oncology and nuclear medicine, Ain Shams University teaching hospitals, patients with a histologically confirmed diagnosis of epithelial ovarian cancer, in the period from January 2017 to December 2020, were included in this retrospective analysis.

Results
Our results showed that ECOG status had a statistically significant correlation with OS and PFS, the better the performance the longer the OS and PFS (p = 0.000, 0.000 respectively). Our study population showed similar results were Platinum sensitive patients showed strong correlation to PFS & OS period with the best in the group platinum sensitive and minimum difference in groups showed no response to platinum or were resistant (p value = 0.000).

Conclusion
our study shows prognostic effects for age, performance status, histological grade, stage, optimal surgery, number of chemotherapy cycles, and platinum sensitivity furthermore after adjustment for different cofounder, high score of age adjusted charleson index &gt;2, stage, ECOG status, platinum sensitivity and optimal cytoreduction were independent prognostic factors affecting OS.
Quality of Life of Prostate Cancer Patients Treated with Androgen Deprivation Therapy in Ain Shams University Hospital
Authors: Mohamed Nora Sayed Mohamed , Ghali Ramy Refaat Youssef , Mosalam Nesreen Ahmed , El Ghamry Wesam Reda Farag , Soliman Mohamed Hassan Ali 
Published: November 2024

Abstract

Background
Prostate cancer is the second most common cancer in men worldwide, according to data from the World Health Organization (WHO) GLOBOCAN Database. The current lifetime risk of prostate cancer for men living in the United States is estimated to be approximately one in eight. In Egypt according to GLOBOCAN number of new cases of prostate cancer 4767 (7.2%), while 5-syear survival 97.5%.

Aim of the Work
In this study, we aimed to evaluate the impact of treatment with Androgen Deprivation Therapy on quality of life for prostate cancer patient treated in Ain Shams University Hospital using a questionnaire from European organization of research and treatment -quality of life for cancer patient – prostate (PR 25) on prostate patient an Arabic index validated.

Patients and Methods
This Cross-sectional study was conducted at tertiary care hospital at Ain Shams University hospitals from August 2022 to February 2023 and performed on a total of 45 prostate cancer patients who attended the outpatient clinic at oncology department at Ain Shams University for hormonal therapy that were diagnosed before 2021.

Results
Our study results revealed that there was no statistically significant correlation between the quality-of-life (QOL) scores and both age of patient and duration of hormonal treatment. In correlation with the demographic characteristics, our study results revealed that the symptom scale score and Functional scale score showed no statistically significant differences with the medical, surgical history of the patient, history of chemotherapy and radiotherapy, ECOG and Metastasis.

Conclusion
The quality-of-life scores (QLQ-PR25) revealed that the mean symptom scale was 41.11 (SD ± 10.94) and the functional scale was 67.22 (SD ± 13.86) with no significant correlation with both age of patient and duration of hormonal treatment. However, the study was single arm and lack the control group which may underestimate the sexual and urinary changes or outcomes due to the intervention by ADT in patients with prostate cancer. Consequently, the present study can burden the knowledge and shed some light on future prospective studies with larger sample sizes and control group demonstrating the long-term outcomes of ADT in patients with prostate cancer regarding the HR-QOL.
The Impact of the HER2 Status(HER2 Low vs HER2 Negative) on the Pathological Response to Neoadjuvant Chemotherapy in Hormonal Receptor Positive Breast Cancer
Authors: Mohamed Nourhan Saeed Abdel-Aziz , El-Leithy Mahmoud Mahmoud Abbas , Helal Thanaa Elsayed Ahmed , Mostafa Mohamed Yassin , Abdel-Aziz Ahmed Hassan , Elghazawy Hagar Ibrahim 
Published: November 2024

Abstract

Background
More than 50% of breast cancers are currently defined as “Human epidermal growth factor receptor 2 (HER2) low breast cancer (BC)”. Nevertheless, little is known about the response and prognosis of HER2-low BC receiving neoadjuvant chemotherapy (NACT).

Aim of the Work
The purpose of our study is to evaluate the impact of HER2status (HER2 low vs zero) on the response to neoadjuvant chemotherapy (NACT) in HER2− BC.

Patients and Methods
This study is a retrospective study that included 96 patients attending the breast clinic at the Clinical Oncology Department, Ain Shams University during the period from 1 January 2020 till 31 December 2022.

Results
A total of 96 patients were included, of whom 68.8% were HER2 0, where HER2 low was represented by 31.2 % of the patients. HER2 low had similar pCR rates in comparison to HER2 0 (13.3% vs 18.2%, P = 0.55). Ki67 is highly significant correlated with pCR, as in patients who achieved pCR, Ki67 percent was of median 35%, while Ki67 was of median 20% in patients who didn’t achieve pCR (P &lt; 0.01).

Conclusion
HER2-low status appears to be associated with a similar pCR rate as HER2-0 in HR positive BC patients.
Retrospective Analysis of Outcomes and Toxicity of Adjuvant Imatinib in Patients with Gastrointestinal Stromal Tumor in Clinical Oncology Department in Ain Shams University
Authors: Abel-salam Riham Essam , Abdel-hakeem Khaled Naguib , Kamel Tarek Hussein , Bayomi Waleed Abdel-moniem , El-din El -Ghoneimy Khaled Kamal , Ahmed Sherief Hassanin 
Published: November 2024

Abstract

Background
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal (GI) tract. Most of them (&gt;75%) are driven by an oncogenic initiating event involving activating mutations of the genes encoding for tyrosine kinase, KIT or platelet derived growth factor receptor alpha (PDGFRA). Efficacy of the tyrosine kinase Inhibitor imatinib is now well established for localized and advanced disease. For localized GISTs, 3 years treatment is the recommended adjuvant therapy for high risk patients. This review aims to describe current knowledge on the issue of adjuvant therapy of primary GISTs in view of available results and to further refine the definition of the population of GIST patients at high risk of relapse including molecular criteria

Aim of the Work
The purpose of this study is to retrospectively analyze the outcomes and toxicity of adjuvant Imatinib in patients with gastrointestinal stromal tumor

Patients and Methods
This study is a retrospective study that included 40 patients attending the sarcoma clinic at the Clinical Oncology Department, Ain Shams University during the period from 1 January 2016 till 31 December 2022.

Results
A total of 40 patients were included. Of whom 47.5% of patients completed 3 year duration of treatment by Imatinib, whereas those who didn't complete their 3 years treatment were presented by 52.5%. Higher DFS was found in those who completed their treatment duration in comparison to the second group with median DFS 67.8 vs 47.9 months respectively P value &lt;0.003 highly significant. Imatinib was generally tolerated and toxicity was reported only in 20% of the study population, and the commonly found side effect was skin rash, followed by hematological toxicities then GIT manifestations. 22.5% of patients developed recurrence of the disease and higher rate of recurrence was found among elderly&gt;60 years, tumor size&gt;10 cm, and higher Ki67.

Conclusion
treatment with adjuvant Imatinib appears to be associated with higher DFS and we'll tolerated side effects
Role of Anterior Segment Optical Coherence Tomography in Evaluation of the Actual Depth versus the Planned Depth of Implanted Intrastromal Corneal Ring Segments in Treatment of Keratoconus
Authors: Oteifa Ahmed Magdy , Metwally Mohamed Gamil , Badran Tamer Abdel Fattah , Tawfik Caroline Atef 
Published: November 2024

Abstract

Background
Keratoconus is a non-inflammatory, progressive and usually bilateral corneal disease characterized by progressive corneal stromal thinning and abnormal corneal steepening causing visual deterioration. ICRS implantation is a safe and reversible procedure that can be used in treatment of keratoconus. The correct position and depth of the ICRS after implantation are crucial to avoid post-operative complications and to improve visual outcomes.

Objective
To compare the actual depth of implanted ICRS with the planned depth using AS-OCT one week, one month and three months post-operatively for better predicting of the visual and refractive outcomes as well as to aid in prevention and early detection of post-operative complications in keratoconic patients undergoing ICRS implantation.

Patients and Methods
A prospective observational uncontrolled case-series study that was done on 10 eyes of 10 patients aiming to compare the actual depth of implanted ICRS (Kerarings) with the planned depth using AS-OCT which took place in Ain Shams University Specialized Hospital and Eye Subspecialty Hospital, Cairo, Egypt.

Results
All implanted ICRSs in all treated eyes showed shallower depth of implantation when compared to the planned depth in the follow up periods. Results have shown that the average measured depth of the ring segments in relation to the corneal thickness was found to be 65.7 % ± 1.7% (range= 63.1% – 68.1%) after 1 week, 67.6% ± 2.2% (range= 63.6% – 70.5%) after 1 month and 66.8% ± 2.2% (range= 63.8% – 70.6%) after 3 months. When comparing the actual depth of implantation to the thinnest pachymetry measured preoperatively, results have shown that the actual depth was found to be 64.6% ± 2.3% (range= 61.1% – 69.1%) after 1 week, 67.0% ± 4.3% (range= 60.8% – 74.9%) after 1 month and 65.3% ± 3.3% (range= 60.2% – 71.1%) after 3 months instead of the planned 80%.

Conclusion
ICRS are implanted at a shallower depth than intended. Stromal compression might have played a role in corneal stromal thinning above the implant and thus causing a false shallower depth of implantation. This can be further studied by implementing a confocal microscopy on larger sample sizes to be able to document actual anterior stromal collagen lamellae compression.
Ocular and Systemic Effects of Intravitreal Dexamethasone Sustained Release Implant in Refractory Diabetic Macular Edema
Authors: Ibrahim Ahmed Mohamed Ahmed , Kabeel Mamdouh Mahmoud , Elbayoumi Boshra Mohamed Ali , Elshormilisy Amr Aly Mohamed , Montaser Ahmed Samir 
Published: November 2024

Abstract

Purpose
Intravitreal therapies with anti-VEGF medications are regarded as effective treatment option. The biodegradable intravitreal implant, Ozurdex (Allergan, Irvine, CA, USA) depends on slow-release dexamethasone. The present study aimed to assess the safety of intravitreal Ozurdex in patients with refractory DME.

Methods
This prospective study included patient with resistant DME who received intravitreal Ozurdex. baseline clinical evaluation, change in best corrected visual acuity BCVA and central retinal thickness CRT were analysed, intra ocular pressure, HbA1c, adverse effects were recorded.

Results
The reported CRT measurements showed significant decrease in the first 3 months post injection. The reported BCV showing significant improvement from the baseline values, there was significant increase in IOP in the first month only which was controlled with medical treatment, with no influence on HbA1c.

Conclusions
for patients with refractory macular oedema, Ozudex implant showed improvement in visual acuity and decreased macular thickness and there was no influence on metabolic control, side effects such as increase of intraocular pressure may require medical treatment.
Comparison between Goldmann Applanation Tonometry and Air Puff Tonometry for Measurement of Intraocular Pressure in Siliconized Eyes
Authors: Samady Hossam Maged Mohamed El , El-Ibiary Hany Mohamed , El Yasser Abd , Zankalony Maguid El , Ali Kandil Haytham Mohamed 
Published: November 2024

Abstract

Background
Silicone oil (SO) has been a part of vitreoretinal surgery since the 1960s. The use of silicone oil in conjunction with advanced vitreous surgical techniques can successfully treat complicated retinal detachment (RD).

Aim of the Work
to compare the intraocular pressure (IOP) measurements following Pars Plana Vitrectomy (PPV) with injection of Silicone Oil (SO) by Goldmann applanation tonometry (GAT) and noncontact Air Puff Tonometer (APT).

Patients and Methods
This study included a total of 165 eyes of 165 patients. Of these 165 patients, 110 have undergone PPV and silicone oil injection, while the remaining 55 participants served as the control group.

Results
The participants in our study were divided into a control group, and a siliconized group which was subdivided into SO 1000 cSt (Group A) and SO 5000 cSt (Group B). The control group had an average age of 50.65±12.26 years, Group A had an average age of 53.53±12.04 years, and Group B had an average age of 55.45±12.02 years. The control group in our study consisted of 28 males (50.9%) and 27 females (49.1%), while Group A had 37 males (67.3%) and 18 females (32.7%), and Group B had 38 males (69.1%) and 17 females (30.9%). Central corneal thickness (CCT) was measured for all participants. The average CCT was 536.53±28.66µm for the control group, 531.67±29.19µm for Group A, and 527.13±28.79µm for Group B. There was no statistically significant difference in the CCT measurements between the study groups (P = 0.410). The average IOP values were obtained using both the airpuff tonometer (APT) and Goldmann applanation tonometry (GAT) methods. In the control group, the average IOP was 16.56±2.98 mmHg using APT and 15.27±2.73 mmHg using GAT. For Group A, the average IOP was 17.09±7.0 mmHg with APT and 15.61±6.43 mmHg with GAT. In Group B, the average IOP was 16.71±4.93 mmHg using APT and 15.13±4.63 mmHg using GAT. The P-value was &gt;0.05 in all groups, indicating that the differences were not statistically significant.

Conclusion
the results showed a correspondence between the Goldmann applanation tonometer (GAT) and the airpuff tonometer (APT) in siliconized eyes. The differences in intraocular pressure (IOP) measurements between the two instruments were minimal and not statistically significant, with APT measurements being slightly higher than GAT measurements. The study also concluded that there is a greater chance of increased IOP following pars plana vitrectomy (PPV) and silicone oil (SO) injection with SO 1000 cSt compared to 5000 cSt, but this difference was not statistically significant. Furthermore, this IOP difference between the two methods was not correlated with age, gender, CCT, or lens status of the patients. Thus, there is good agreement between the two methods.
Incidence of Persistent Avascular Retina Post Intravitreal Injection of Ranibizumab for Retinopathy of Prematurity
Authors: Labeeb Jacklin Henry Thabet , Ziko Osman , Al-Feky Mariam 
Published: November 2024

Abstract

Background
Retinopathy of prematurity (ROP) is a vision threatening retinal disease caused by vascular proliferation in the immature retina of premature infants, the lower the gestational age and birth weight, the higher the chance of developing ROP.

Aim of the Work
Our study discuss the incidence of PAR after 6 months of follow up and the recurrence rate of retinopathy of prematurity (ROP) after treatment with intravitreal injection of ranibizumab.

Patients and Methods
25 eyes of 13 patients with type 1 ROP and AROP underwent intravitreal injection of ranibizumab as an initial treatment between October 2021 and November 2022 were included in this study.

Results
Data of patients included GA, BW, age at initial injection (weeks), type of ROP, the recurrence rate of ROP and number of injections needed, incidence of PAR and if complete retinal vascularization occurred, the age at complete retinal vascularization (weeks) were analyzed, if FFA was done to assess leakage in areas of PAR and laser was done to the area of PAR. 11 eyes (44%) of the studied eyes had near complete vascularization at PMA of 45-66 weeks, and the remaining 14 eyes(56%) had PAR after 6 months of follow up after IVR injection. Recurrence occurred in three eyes (12%), one eye of them was injected twice and two eyes had three injections.

Conclusion
Screening for ROP should be taken seriously and should include all infants at risk of developing ROP to avoid visual complications. Recently the use of intravitreal injection of ranibizumab is effective in treating advanced ROP. The treatment with IVR lead to complete retinal vascularization at PMA 45-66 weeks. In case of PAR, FFA may be useful before applying laser to detect any vascular leakage in this avascular retina. Recurrence of ROP can occur during a period of 5-7 weeks after IVR injection, so long term follow up should be done for proper observation and management of any recurrence.