bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crystalline Carbon Nitride Semiconductors for Photocatalytic Water Splitting
Authors: Lin Lihua , Yu Zhiyang , Wang Xinchen 
Published: October 2018

AbstractConjugated carbon nitride (CN) is an emerging and promising semiconductor photocatalyst for water photolysis owing to its unique properties. However, the traditional thermally induced polymerization of N‐containing precursors typically produces melon‐based CN solids with amorphous or semi‐crystalline structures with only moderate photocatalytic performance. Many strategies have been developed to prepare crystalline CNs (CCNs), such as high‐temperature and high‐pressure routes, ionothermal synthesis, and microwave‐assisted synthesis. In this Minireview, we summarize the progress that has been made in the synthesis of CCNs and their application in photocatalytic water splitting reactions. Three kinds of CCNs are mainly discussed according to their polymeric subunits. Challenges associated with CCNs and their future development are also included.
A Generic Method for Preparing Hollow Mesoporous Silica Catalytic Nanoreactors with Metal Oxide Nanoparticles inside Their Cavities
Authors: Li Kaijie , Wei Jinxia , Yu Hongbo , Xu Pengyao , Wang Jiahua , Yin Hongfeng , Cohen Stuart Martien A. , Wang Junyou , Zhou Shenghu 
Published: October 2018

AbstractWe report a facile and generic method for the synthesis of hollow mesoporous silica nanoreactors (HMSNs) with small‐sized metal oxide nanoparticles (NPs) inside their cavities. They were made by deposition of silica onto metal‐containing charge‐driven polymer micelles and subsequent calcination. The micelles consist of 1) negatively charged supramolecular polyelectrolyte chains of bis‐ligand‐bound metal ions, and 2) water‐soluble, neutral/positive diblock copolymers. Owing to the facile coordination between transition‐metal ion and the employed bidentate ligand, a series of HMSNs with <2 nm MxOy NPs inside cavities (M=Mn, Co, Ni, Cu, or Zn) were obtained by simply varying the metal ions inside the micelles. The developed method circumvents the pre‐ and post‐synthesis of metal oxide NPs; after calcination, hollow mesoporous nanostructures containing small‐sized metal oxide NPs inside their cavities are directly obtained. The CoxOy‐functionalized HMSNs catalyze the degradation of various dyes with H2O2.
The impact of the economic crisis on micro, small, and medium enterprises and their crisis mitigation measures in Southeast Asia with reference to Indonesia
Authors: Tambunan Tulus T. H. 
Published: October 2018

AbstractThe literature on the impact of the economic crisis on micro, small, and medium enterprises (MSMEs) and how they deal with it is still limited. Focusing on the 1997–1998 Asian financial crisis and the 2008–2009 global financial crisis, this study aims to fill this gap. There are two key questions: how these two economic crises have affected MSMEs and what were then their crisis mitigation (CM) measures. To answer these questions, this study reviews experiences in several countries in Southeast Asia with the impacts of these two crises on MSMEs and their responses to the crises. It shows that the impact of the 1997/1998 crisis on MSMEs is different from the 2008/2009 crisis. Findings from a survey of MSMEs affected by the 2008–2009 crisis indicate that finding new customers or markets in other countries unaffected by the crisis or switching to the domestic market was the most widely adopted CM measure. For other respondents who made adjustments to their workforce, the most important form was to reduce working day.
Whole synthetic pathway engineering of recombinant protein production
Authors: Brown Adam J. , Gibson Suzanne J. , Hatton Diane , Arnall Claire L. , James David C. 
Published: October 2018

AbstractThe output from protein biomanufacturing systems is a function of total host cell biomass synthetic capacity and recombinant protein production per unit cell biomass. In this study, we describe how these two properties can be simultaneously optimized via design of a product‐specific combination of synthetic DNA parts to maximize flux through the protein synthetic pathway and the use of a host cell chassis with an increased capability to synthesize both cell and product biomass. Using secreted alkaline phosphatase (SEAP) production in Chinese hamster ovary cells as our example, we demonstrate how an optimal composition of input components can be assembled from a minimal toolbox containing rationally designed promoters, untranslated regions, signal peptides, product coding sequences, cell chassis, and genetic effectors. Product titer was increased 10‐fold, compared with a standard reference system by (a) identifying genetic components that acted in concert to maximize the rates of SEAP transcription, translation, and translocation, (b) selection of a cell chassis with increased biomass synthetic capacity, and (c) engineering the host cell factory’s capacity for protein folding and secretion. This whole synthetic pathway engineering process to design optimal expression cassette–chassis combinations should be applicable to diverse recombinant protein and host cell‐type contexts.
Salophen Copper(II) Complex‐Assisted Click Reactions for Fast Synthesis of 1,2,3‐Triazoles Based on Naphthalene‐1,4‐dione Scaffold, Antibacterial Evaluation, and Molecular Docking Studies
Authors: Abbaspour Sima , Keivanloo Ali , Bakherad Mohammad , Sepehri Saghi 
Published: October 2018

AbstractThe salophen copper(II) complex was successfully used for the efficient synthesis of new 1,2,3‐triazoles based on the naphthalene‐1,4‐dione scaffold. The reaction of 2‐chloro‐3‐(prop‐2‐yn‐1‐yloxy)naphthalene‐1,4‐dione or 2,3‐bis(prop‐2‐yn‐1‐yloxy)naphthalene‐1,4‐dione with aromatic azides in the presence of a low copper catalyst (loading 1 mol‐%) afforded 2‐chloro‐3‐[(1‐phenyl‐1H‐1,2,3‐triazol‐4‐yl)methoxy]naphthalene‐1,4‐dione or 2,3‐bis[(1‐phenyl‐1H‐1,2,3‐triazol‐4‐yl)methoxy]naphthalene‐1,4‐dione, respectively. The advantages of these reactions are short reaction times, high‐to‐excellent reaction yields, operational simplicity, and mild experimental conditions. The new 1,2,3‐triazoles obtained were screened for their in vitro antibacterial activities and were subjected to molecular docking studies.
Why does FFR‐guided PCI improve clinical outcomes? The missing link of post‐PCI ischemia reduction
Authors: Seto Arnold H. , Kern Morton J. 
Published: October 2018

Key Points
This study demonstrates that FFR‐guided PCI reduces noninvasively assessed ischemia more effectively than angiography‐guided PCI.
Improved ischemia resolution was associated with improved clinical outcomes.
Superior ischemia resolution is likely the dominant mechanism of improved outcomes with FFR in clinical outcome trials, as opposed to avoidance of inappropriate stenting and its associated adverse events.
Aortic dissection: Is the false lumen really important?
Authors: Shatila Wassim , Krajcer Zvonimir 
Published: October 2018

Key Points
Aortic dissection is associated with a high mortality rate and has been increasingly treated with endovascular therapy.
False lumen (FL) patency has been shown to be associated with worse outcomes.
FL interventions that incorporate the FLIRT (FL intervention to promote remodeling and thrombosis) concept have been associated with improved aortic remodeling that may confer favorable long‐term outcomes.
Volume brings value
Authors: Gogas Bill D. , Chen Shao‐Liang 
Published: October 2018

Key Points

What the article teaches
The article highlights the competency of high volume operators across institutions that despite moving to lower volume centers retain their good clinical outcomes.

How it will impact practice
Although current U.S. based guidelines suggest a volume of at least 50 PCIs annually for operators to retain clinical competency this estimate may be a poor index to guarantee optimal clinical outcomes.

What new research/study would help answer the question
New studies using a comprehensive definition to define an experienced operator from the Asia‐Pacific—a geographic area that has pioneered in complex coronary interventions—need to elute on the threshold of adequate clinical competency stratified according to clinical complexity.
Clinical impact of baseline chronic kidney disease in patients undergoing transcatheter or surgical aortic valve replacement
Authors: Pineda Andres M. , Kevin Harrison J. , Kleiman Neal S. , Reardon Michael J. , Conte John V. , O'Hair Daniel P. , Chetcuti Stanley J. , Huang Jian , Yakubov Steven J. , Popma Jeffrey J. , Beohar Nirat 
Published: October 2018

AbstractObjectivesTo assess the treatment effect of TAVR versus SAVR on clinical outcomes to 3 years in patients stratified by chronic kidney disease (CKD) by retrospectively studying patients randomized to TAVR or SAVR.BackgroundThe impact of CKD on mid‐term outcomes of patients undergoing TAVR versus SAVR is unclear.MethodsPatients randomized to TAVR or SAVR in the CoreValve US Pivotal High Risk Trial were retrospectively stratified by eGFR: none/mild or moderate/severe CKD. To evaluate the impact of baseline CKD in TAVR patients only, all patients undergoing an attempted TAVR implant in the US Pivotal Trial and CAS were stratified by baseline eGFR into none/mild, moderate, and severe CKD. The primary endpoint was major adverse cardiovascular and renal events (MACRE), a composite of all‐cause mortality, myocardial infarction, stroke/TIA, and new requirement of dialysis.ResultsModerate/severe CKD was present in 62.7% and 60.7% of high‐risk patients randomized to TAVR or SAVR, respectively. Baseline characteristics were similar between TAVR and SAVR patients in both CKD subgroups, except for higher rates of diabetes and higher serum creatinine in SAVR patients. Among high‐risk patients with moderate/severe CKD, TAVR provided a lower 3‐year MACRE rate compared with SAVR: 42.1% vs. 51.0, P = .04. Of 3,733 extreme‐ and high‐risk TAVR patients, 39.9% had none/mild, 53.8% moderate, and 6.4% severe CKD. Worsening baseline CKD was associated with increased 3‐year MACRE rates [none/mild 51.5%, moderate 54.5%, severe 63.1%, P = .001].ConclusionsTAVR results in lower 3‐year MACRE versus SAVR in high‐risk patients with moderate/severe CKD. In patients undergoing TAVR, worsening CKD increases mid‐term mortality and MACRE. Randomized trials of TAVR vs. SAVR in patients with moderate‐severe CKD would help elucidate the best treatment for these complex patients.Trial RegistrationCoreValve US Pivotal Trial: NCT01240902.CoreValve Continued Access Study: NCT01531374.
Thermodynamic Limitations of the Catalyst Design Space for Methanol Production from Methane
Authors: Jocz Jennifer N. , Medford Andrew J. , Sievers Carsten 
Published: October 2018

AbstractCurrent efforts to overcome the challenges of direct methane to methanol processes have focused on designing heterogeneous catalysts that perform methane partial oxidation using cheap and abundant oxidants such as molecular oxygen and water. An evaluation of the thermodynamic limitations of methanol production with the use of these oxidants is required to understand the maximum possible conversion and selectivity for a given feed composition and temperature. When O2 is present, the formation of the most thermodynamically stable product, carbon dioxide, must be inhibited. At practical temperatures for moderate scale processes, water as the sole oxidant results in extremely low steady‐state methane conversion, but higher yields can be achieved with coupled surface reactions. This work evaluates these thermodynamic challenges and opportunities for catalysts that can selectively oxidize methane to methanol with oxygen and water and discusses routes for achieving high methanol yields.
Iron‐Doped Nickel Molybdate with Enhanced Oxygen Evolution Kinetics
Authors: Chen Jiayi , Zhao Guoqiang , Chen Yaping , Rui Kun , Mao Hui , Dou Shi Xue , Sun Wenping 
Published: October 2018

AbstractElectrochemical water splitting is one of the potential approaches for making renewable energy production and storage viable. The oxygen evolution reaction (OER), as a sluggish four‐electron electrochemical reaction, has to overcome high overpotential to accomplish overall water splitting. Therefore, developing low‐cost and highly active OER catalysts is the key for achieving efficient and economical water electrolysis. In this work, Fe‐doped NiMoO4 was synthesized and evaluated as the OER catalyst in alkaline medium. Fe3+ doping helps to regulate the electronic structure of Ni centers in NiMoO4, which consequently promotes the catalytic activity of NiMoO4. The overpotential to reach a current density of 10 mA cm−2 is 299 mV in 1 m KOH for the optimal Ni0.9Fe0.1MoO4, which is 65 mV lower than that for NiMoO4. Further, the catalyst also shows exceptional performance stability during a 2 h chronopotentiometry testing. Moreover, the real catalytically active center of Ni0.9Fe0.1MoO4 is also unraveled based on the ex situ characterizations. These results provide new alternatives for precious‐metal‐free catalysts for alkaline OER and also expand the Fe‐doping‐induced synergistic effect towards performance enhancement to new catalyst systems.
Enantioselective [2+2] Photocycloaddition Reactions of Enones and Olefins with Visible Light Mediated by N,N′‐Dioxide–Metal Complexes
Authors: Yu Han , Dong Shunxi , Yao Qian , Chen Long , Zhang Dong , Liu Xiaohua , Feng Xiaoming 
Published: October 2018

AbstractA 2‐alkenoylpyridine‐bound N,N′‐dioxide–TbIII complex has been found to absorb visible light to reach the excited state, leading to the direct visible‐light‐excited catalytic enantioselective [2+2] cycloaddition of 2‐alkenoylpyridines to various alkenes in the absence of an additional photosensitizer. Diverse enantioenriched cyclobutanes were successfully obtained (yields up to 70 %, >19:1 d.r., 92 % ee). The new chiral terbium(III) complex features a bathochromic shift, lower excitation energy, and facile intersystem crossing due to paramagnetic and heavy‐atom effects, which enable the antenna 2‐alkenoylpyridines to be excited. For comparison, a chiral N,N′‐dioxide–ScIII complex in combination with [Ru(bpy)3]Cl2 was efficient in the enantioselective photocycloaddition reactions of 2′‐hydroxychalcones with alkenes, thereby revealing that both substrates and metal salts have significant effects on the reaction.
Septin‐associated proteins Aim44 and Nis1 traffic between the bud neck and the nucleus in the yeast Saccharomyces cerevisiae
Authors: Perez Adam M. , Thorner Jeremy 
Published: October 2018

AbstractIn budding yeast, a collar of septin filaments at the neck between a mother cell and its bud marks the incipient site for cell division and serves as a scaffold that recruits proteins required for proper spatial and temporal execution of cytokinesis. A set of interacting proteins that localize at or near the bud neck, including Aim44/Gps1, Nba1 and Nis1, also has been implicated in preventing Cdc42‐dependent bud site re‐establishment at the division site. We found that, at their endogenous level, Aim44 and Nis1 robustly localize sequentially at the septin collar. Strikingly, however, when overproduced, both proteins shift their subcellular distribution predominantly to the nucleus. Aim44 localizes with the inner nuclear envelope, as well as at the plasma membrane, whereas Nis1 accumulates within the nucleus, indicating that these proteins normally undergo nucleocytoplasmic shuttling. Of the 14 yeast karyopherins, Kap123/Yrb4 is the primary importin for Aim44, whereas several importins mediate Nis1 nuclear entry. Conversely, Kap124/Xpo1/Crm1 is the primary exportin for Nis1, whereas both Xpo1 and Cse1/Kap109 likely contribute to Aim44 nuclear export. Even when endogenously expressed, Nis1 accumulates in the nucleus when Nba1 is absent. When either Aim44 or Nis1 are overexpressed, Nba1 is displaced from the bud neck, further consistent with the mutual interactions of these proteins. Collectively, our results indicate that a previously unappreciated level at which localization of septin‐associated proteins is controlled is via regulation of their nucleocytoplasmic shuttling, which places constraints on their availability for complex formation with other partners at the bud neck.
Cisplatin versus cetuximab with definitive concurrent radiotherapy for head and neck squamous cell carcinoma: An analysis of Veterans Health Affairs data
Authors: Bauml Joshua M. , Vinnakota Ravi , Anna Park Yeun‐Hee , Bates Susan E. , Fojo Tito , Aggarwal Charu , Di Stefano Jessica , Knepley Christina , Limaye Sewanti , Mamtani Ronac , Wisnivesky Juan , Damjanov Nevena , Langer Corey J. , Cohen Roger B. , Sigel Keith 
Published: October 2018

BackgroundThe addition of cisplatin or cetuximab to radiation therapy (RT) improves outcomes in comparison with RT alone in the nonoperative management of head and neck squamous cell carcinoma (HNSCC), but limited data exist for comparing these approaches. Using Veterans Health Affairs data, this study compared the outcomes of patients treated with RT plus cisplatin or cetuximab.MethodsPatients with stage III to IVb HNSCC who had been treated nonsurgically with RT and cisplatin or cetuximab from 2000 to 2016 within the Veterans Health Affairs system were identified. Patients were analyzed by the drug used in the first treatment cycle (intent to treat). Overall survival (OS) was compared by treatment group with Cox regression models, and propensity score (PS) methods were used to account for a treatment allocation bias. The risk of toxicities was determined, with logistic regression models fit into propensity‐matched cohorts.ResultsA total of 4520 patients were included in the analysis with a median follow‐up of 3 years: 83% received cisplatin. Cisplatin patients were younger (P < .001) and had fewer comorbidities (P < .001). In an unmatched analysis, cetuximab was associated with inferior OS (P < .001). After PS matching, cetuximab treatment remained statistically significantly associated with inferior OS (1.7 vs 4.1 years; hazard ratio, 1.61; 95% confidence interval, 1.44‐1.79; P < .001). These differences remained significant across all primary HNSCC subsites and in comparison with low‐ and high‐dose cisplatin.ConclusionsCetuximab with RT yields inferior OS in comparison with cisplatin for the nonoperative management of stage III to IVb HNSCC. According to this study, cisplatin may be the most appropriate partner for RT in this setting.
Finding influential users of web event in social media
Authors: Ma Qichen , Luo Xiangfeng , Zhuge Hai 
Published: October 2018

SummaryUsers of social media have different influences on the evolution of a Web event. Finding influential users could benefit such information services as recommendation and market analysis. However, most of the existing methods are only based on social networks of users or user behaviors while the role of the contents contributed by users in social media is ignored. In fact, a Web event evolves with both user behaviors and the contents. This paper proposes an approach to find influential users by extracting user behavior network and association network of words within the contents and then uses PageRank algorithm and HITS algorithm to calculate the influence of users on the integration of two networks. The proposed approach is effective on several real‐world datasets.
Claims Data Studies of Direct Oral Anticoagulants Can Achieve Balance in Important Clinical Parameters Only Observable in Electronic Health Records
Authors: Huybrechts Krista F. , Gopalakrishnan Chandrasekar , Franklin Jessica M. , Zint Kristina , Franca Lionel Riou , Bartels Dorothee B. , Landon Joan , Schneeweiss Sebastian 
Published: October 2018

Claims databases provide information on the effects of direct oral anticoagulants (DOACs) as used in routine care but may not contain important data on clinical characteristics, which may be captured in electronic health records (EHRs). Within a US claims database, we identified patients initiating a DOAC or warfarin between October 2010 and December 2014. Propensity score (PS) matching, 1:1, was used to balance 78 claims‐defined baseline characteristics. We evaluated whether balance was achieved in patient characteristics immeasurable in the claims data study by evaluating the balance in clinical information (using absolute standardized differences (aSDs)) from linked EHR data. From a claims data cohort study of 140,187 patients, 5,935 (4.2%) were linked to EHR data. After PS matching, almost all EHR‐defined patient characteristics were well balanced (aSD < 0.1). A new user active comparator design with 1:1 PS matching on many patient characteristics improved balance on clinical risk factors observed in EHRs but not in claims data.
User scheduling and power allocation for nonfull buffer traffic in NOMA downlink systems
Authors: Gemici Ömer Faruk , Kara Fatih , Hökelek İbrahim , Çırpan Hakan Ali 
Published: October 2018

SummaryNonorthogonal multiple access (NOMA) is one of the key technologies for 5G, where the system capacity can be increased by allowing simultaneous transmission of multiple users at the same radio resource. The most of the proportional fairness (PF)–based resource allocation studies for NOMA systems assumes full buffer traffic model, while the traffic in real‐life scenarios is generally nonfull buffer. In this paper, we propose User Demand–Based Proportional Fairness (UDB‐PF) and Proportional User Satisfaction Fairness (PUSF) algorithms for user scheduling and power allocation in NOMA downlink systems when traffic demands of the users are limited and time‐varying. UDB‐PF extends the PF‐based scheduling by allocating optimum power levels towards satisfying the traffic demand constraints of user pair in each resource block. The objective of PUSF is to maximize the network‐wide user satisfaction by allocating sufficient frequency and power resources according to traffic demands of the users. In both cases, user groups are selected first to simultaneously transmit their signals at the same frequency resource, while the optimal transmission power level is assigned to each user to optimize the underlying objective function. In addition, the genetic algorithm (GA) approach is employed for user group selection to reduce the computational complexity. When the user traffic rate requirements change rapidly over time, UDB‐PF yields better sum rate (throughput) while PUSF provides better network‐wide user satisfaction results compared with the PF‐based user scheduling. We also observed that the GA‐based user group selection significantly reduced the computational load while achieving the comparable results of the exhaustive search.