bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repetitive transcranial magnetic stimulation for functional tremor: A randomized, double‐blind, controlled study
Authors: Taib Simon , Ory‐Magne Fabienne , Brefel‐Courbon Christine , Moreau Ysé , Thalamas Claire , Arbus Christophe , Simonetta‐Moreau Marion 
Published: June 2019

ABSTRACTObjectivesThe objective of this study was to compare the effect on functional tremor of active versus sham repetitive transcranial magnetic stimulation and investigate whether the addition of hypnosis might help to prolong any repetitive transcranial magnetic stimulation–induced therapeutic effect.MethodsWe compared the effect of 5 consecutive daily sessions of active/sham repetitive transcranial magnetic stimulation on functional tremor, at 1 and 2 months, in a randomized, double‐blind, 2‐arm, parallel‐controlled study. In a second open‐label phase, all patients underwent 3 weekly sessions of hypnosis combined with single sessions of real repetitive transcranial magnetic stimulation. The primary outcome was a change in the Psychogenic Movement Disorder Rating Scale at month 1 when compared with baseline. Secondary outcomes were changes in the Psychogenic Movement Disorder Rating Scale and Tremor subscores, the 36‐item Short Form Health Survey, the Self‐Report Hospital Anxiety and Depression Scale, the Hamilton Depression Rating Scale, and the Clinical Global Impression Scale assessed at months 1, 2, 6, and 12.ResultsA total of 33 outpatients affected by functional tremor were screened, and 18 outpatients fulfilling the inclusion criteria (8 men, 10 women) were randomized. One month after the intervention, the mean Psychogenic Movement Disorder Rating Scale score had decreased in both groups, but the differences from baseline were only significant in the active repetitive transcranial magnetic stimulation group (P < .001). This remained significant at month 2 (P < .001). The significant decrease of the Psychogenic Movement Disorder Rating Scale and Tremor subscores were maintained at months 6 and 12 for the active repetitive transcranial magnetic stimulation group. For the control group, the Psychogenic Movement Disorder Rating Scale score had returned almost to its baseline value by month 2 and remained unchanged at months 6 and 12.ConclusionRepetitive transcranial magnetic stimulation could represent a valuable therapeutic option in the management of functional tremor. © 2019 International Parkinson and Movement Disorder Society
Decreased water T2 in fatty infiltrated skeletal muscles of patients with neuromuscular diseases
Authors: Schlaeger Sarah , Weidlich Dominik , Klupp Elisabeth , Montagnese Federica , Deschauer Marcus , Schoser Benedikt , Bublitz Sarah , Ruschke Stefan , Zimmer Claus , Rummeny Ernst J. , Kirschke Jan S. , Karampinos Dimitrios C. 
Published: June 2019

Quantitative imaging techniques are emerging in the field of magnetic resonance imaging of neuromuscular diseases (NMD). T2 of water (T2w) is considered an important imaging marker to assess acute and chronic alterations of the muscle fibers, being generally interpreted as an indicator for “disease activity” in the muscle tissue. To validate the accuracy and robustness of quantitative imaging methods, 1H magnetic resonance spectroscopy (MRS) can be used as a gold standard.The purpose of the present work was to investigate T2w of remaining muscle tissue in regions of higher proton density fat fraction (PDFF) in 40 patients with defined NMD using multi‐TE single‐voxel 1H MRS. Patients underwent MR measurements on a 3 T system to perform a multi‐TE single‐voxel stimulated echo acquisition method (STEAM) MRS (TE = 11/15/20/25(/35) ms) in regions of healthy, edematous and fatty thigh muscle tissue. Muscle regions for MRS were selected based on T2‐weighted water and fat images of a two‐echo 2D Dixon TSE.MRS results were confined to regions with qualitatively defined remaining muscle tissue without edema and high fat content, based on visual grading of the imaging data. The results showed decreased T2w values with increasing PDFF with R2 = 0.45 (p < 10−3) (linear fit) and with R2 = 0.51 (exponential fit).The observed dependence of T2w on PDFF should be considered when using T2w as a marker in NMD imaging and when performing single‐voxel MRS for T2w in regions enclosing edematous, nonedematous and fatty infiltrated muscle tissue.
Developing patient and public involvement and engagement (PPIE) in diabetes research: a local approach
Authors: Preston Johanna L , Berryman Victoria R , Hancock Angela , Pattrick Melanie , Worthington Anne , Hitman Graham A , Hood Gillian A 
Published: June 2019

AbstractIn this paper, we describe our understanding of what patient and public involvement and engagement (PPIE) in diabetes research actually means to our local Diabetes Research Group (DRG) for Queen Mary, University of London and Barts Health NHS Trust. We describe the development of our local partnership with patients and the public to improve research and subsequently the health of our population. We explore how successful partnerships in PPIE can be achieved and maintained; and highlight the benefits and value of working with patients and the public to improve diabetes research and thereby clinical care for people living with diabetes. Ongoing challenges in managing PPIE in our DRG are highlighted, as well as the need to continually evaluate and embrace new methods of working. Two event examples, which took place in 2018, are then described to demonstrate our ongoing approach in continuing and developing the local DRG PPIE strategy. Copyright © 2019 John Wiley & Sons.
Structured diabetes education outcomes: looking beyond HbA1c. A systematic review
Authors: McCay Deirdre , Hill Alyson , Coates Vivien , O'Kane Maurice , McGuigan Karen 
Published: June 2019

AbstractDiabetes education aims to equip people with diabetes with positive self‐care behaviours and management strategies to improve glycaemic control. The preferred outcome measure of education effectiveness is often HbA1c reduction. However, the move towards person‐centred education has led to renewed calls to capture associated behavioural and psychosocial change. The aim of this study was to review indicators of diabetes education efficacy in light of the growing emphasis on person‐centric care.A systematic search of MEDLINE, EMBASE, PsycINFO, CINAHL and Scopus databases, from January 2006 to December 2016, was conducted. Studies meeting the inclusion criteria, focusing on diabetes education effectiveness primarily measured using HbA1c, were selected.Twenty‐three studies were included, comprising 6747 participants. They yielded mixed results, with 13 studies reporting significant reductions in HbA1c following intervention. Thirteen studies assessed multiple behavioural and psychosocial measures as secondary outcomes with significant, positive changes in these outcomes following intervention. Studies utilising diabetes‐specific measures yielded positive results.It was concluded successful diabetes education involves changing participant cognitions and behaviours. Changes in behavioural and psychosocial aspects should inform education effectiveness. Development of effective diabetes education programmes requires better understanding of how they affect behavioural and psychosocial change, facilitating glycaemic control. Copyright © 2019 John Wiley & Sons.
Improving patient care in monogenic diabetes through research and education
Authors: Shepherd Maggie 
Published: June 2019

AbstractThe 2019 Arnold Bloom lecture reviewed the progress in monogenic diabetes since the start of the service in Exeter in 1995 to present day.The impact of a correct molecular genetic diagnosis has been profound for many patients who have been able to stop insulin injections even after many years on this treatment. However, there remain many patients who are still not correctly diagnosed and long delays between initial diabetes diagnosis and correct genetic diagnosis remain. Raising awareness of monogenic diabetes across the UK has been aided by a national network of genetic diabetes nurses (GDNs). GDNs educate health care professionals about genetic forms of diabetes and are able to provide advice to patients and their families following a positive genetic diagnosis.Challenges in the management of monogenic diabetes still remain. Systematic approaches are being instigated to ensure correct molecular genetic diagnosis is made as close to the initial diabetes diagnosis as possible, and research is being undertaken to identify what support is needed for those receiving ‘unexpected’ genetic results. Management of monogenic diabetes pregnancy can be complex as many women with the most common forms of monogenic diabetes are best treated with sulphonylureas outside pregnancy and fetal genotype can affect birthweight so there are a number of issues to consider. Future management of pregnancy in these cases may be aided by use of cell free fetal DNA testing. Further information on monogenic diabetes can be found at www.diabetesgenes.org. Copyright © 2019 John Wiley & Sons.
Determination of good pharmacovigilance reporting practices in Quebec hospital pharmacies using a modified Delphi method
Authors: Rault Pauline , Mégrourèche Émilie , Labarre Jean‐Simon , Pettersen‐Coulombe Flavie , Lebel Denis , Bussières Jean‐François 
Published: June 2019

AbstractPurposeMany published guidelines are available for health care providers describing the best way to manage patient's adverse drug reactions (ADRs). However, there is a lack of guidance on the best way to promote and manage ADR reporting within hospitals. The goal of this study was to develop good pharmacovigilance reporting practices (GPRPs).MethodsThis descriptive study used a modified Delphi method. The research team developed 41 statements, according to a modified Specific Measurable Attainable Realistic Timely (SMART) method and grouped them in six categories: organization (n = 12 statements), pharmacovigilance committee (n = 4), database (n = 5), training (n = 5), tools (n = 3), and quality (n = 12). The Delphi consultation (two online rounds, conducted in 2018) involved directors of pharmacy in Quebec hospitals.ResultsOf 30 directors of pharmacy invited to participate in the first round, 27 (90%) did so. Following this round, the wording of five statements was modified according to pre‐established rules. Twenty‐five (93%) of the original 27 participants responded during the second round. Of the initial 41 statements, 37 were selected (average score ≥ 7); the other four were eliminated. Of the 37 statements selected, 22 had a “must do” formulation, 12 had a “should do” formulation, and three had a “may do” formulation.ConclusionUsing a modified Delphi method, we established a set of GPRPs for hospital pharmacy based on 37 statements. To our knowledge, these are the first GPRPs published in the hospital pharmacy literature.
Controlled syntheses of polythiophene nanoparticles with plain and hollow nanostructures templated from unimolecular micelles
Authors: Bian Yawen , Yang Chenyu , Gu Qiaosheng , Zhu Xinyuan , Wang Youfu , Zhang Xueli 
Published: June 2019

ABSTRACTPolythiophene nanoparticles (PTNs), as one of the typical conjugated polymer nanoparticles (CPNs) with novel optical and electronic properties have won extensive attentions, especially their applications in electronics and bioimaging. However, PTNs obtained with traditional methods are usually nonuniform or unstable. Herein, we developed a novel method to prepare uniform and stable PTNs templated from star‐like unimolecular micelles. Cyclodextrin‐cored unimolecular micelles with tailored components were prepared through atom transfer radical polymerization, and PTNs with plain or hollow nanostructures can be obtained via crosslinking the suspended thiophene units in designed domain of unimolecular micelles. The unimolecular micelles and PTNs were characterized via nuclear magnetic resonance, Fourier transform infrared, transmission electron microscopy, atomic force microscopy, dynamic light scattering, ultraviolet–visible, and photoluminescence, indicating that the PTNs exhibit uniform size, controllable surface chemistry, and well‐defined nanostructures. The obtained PTNs have potential applications in optics, electronics, and bioimaging. Also, this provides a new way to synthesize CPNs with tailored sizes, nanostructures, and surface chemistry. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1550–1555
Isotactic polypropylene reversible crystallization investigated by modulated temperature and quasi‐isothermal FTIR
Authors: Di Lisio Valerio , Sturabotti Elisa , Francolini Iolanda , Piozzi Antonella , Martinelli Andrea 
Published: June 2019

ABSTRACTModulated temperature techniques allow to separate the reversing and non‐reversing contributions of material transitions. To investigate reversible crystallization and melting of isotactic polypropylene (iPP) at microstructural level, in this research, modulated temperature Fourier transform infrared (MTFTIR) and quasi‐isothermal FTIR (QIFTIR) analyses are used. By following the intensity variation of iPP regularity bands, associated with 31 helix structures of different lengths (n repeating units), MTFTIR evidences that, independently from helix length, a reversing coil–helix transition takes place few degrees below the non‐reversing crystallization onset. By comparing spectroscopic and differential scanning calorimetry experiments performed in quasi‐isothermal conditions, the reversing transition was found to be associated with the reversible melting‐crystallization phenomenon. Moreover, QIFTIR evidences that helices of different lengths contribute differently to the reversible transition: the helices composed of n = 10 and n = 12 are active into all the explored temperature range (30–130 °C) whereas the shortest (n = 6) and the longest (n > 15) helices contribute to reversibility at T > 100 °C. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 922–931
Binding of multiple SO2 molecules to small gold cluster anions (AuN−, AuNOH−, N = 1‐8)
Authors: Reina Miguel , Wallace William T. , Wyrwas Richard B. , Whetten Robert L. , Martínez Ana 
Published: June 2019

AbstractThe binding of SO2 on gas‐phase gold cluster anions, AuN−, and their hydroxide counterparts, AuNOH−, have been studied using density functional theory combined with flow reactor/time‐of‐flight mass spectrometry techniques. SO2 is adsorbed on all of the AuN− and AuNOH− clusters (N = 1‐8) and the hydroxide clusters are more active than the bare anionic clusters. Successive additions of SO2 molecules (up to four) have been analyzed. In all cases, anionic clusters are shown to bind multiple SO2 molecules. Theoretical analyses are in agreement with the experimental results, showing that the addition of more than one molecule is thermodynamically favorable. Larger clusters do not necessarily absorb more molecules, as different SO2 binding motifs on these clusters are present. These results provide important insight for the potential use of these anionic clusters as SO2 hunters.
Adipose-Derived Stromal Cells Are Capable of Restoring Bone Regeneration After Post-Traumatic Osteomyelitis and Modulate B-Cell Response
Authors: Wagner Johannes Maximilian , Reinkemeier Felix , Wallner Christoph , Dadras Mehran , Huber Julika , Schmidt Sonja Verena , Drysch Marius , Dittfeld Stephanie , Jaurich Henriette , Becerikli Mustafa , Becker Kathrin , Rauch Nicole , Duhan Vikas , Lehnhardt Marcus , Behr Björn 
Published: June 2019

Abstract
Bone infections are a frequent cause for large bony defects with a reduced healing capacity. In previous findings, we could already show diminished healing capacity after bone infections, despite the absence of the causing agent, Staphylococcus aureus. Moreover, these bony defects showed reduced osteoblastogenesis and increased osteoclastogenesis, meaning elevated bone resorption ongoing with an elevated B-cell activity. To overcome the negative effects of this postinfectious inflammatory state, we tried to use the regenerative capacity of mesenchymal stem cells derived from adipose tissue (adipose-derived stem cells [ASCs]) to improve bone regeneration and moreover were curious about immunomodulation of applicated stem cells in this setting. Therefore, we used our established murine animal model and applicated ASCs locally after sufficient debridement of infected bones. Bone regeneration and resorption as well as immunological markers were investigated via histology, immunohistochemistry, Western blot, and fluorescence-activated cell scanning (FACS) analysis and μ-computed tomography (CT) analysis. Interestingly, ASCs were able to restore bone healing via elevation of osteoblastogenesis and downregulation of osteoclasts. Surprisingly, stem cells showed an impact on the innate immune system, downregulating B-cell population. In summary, these data provide a fascinating new and innovative approach, supporting bone healing after bacterial infections and moreover gain insights into the complex ceremony of stem cell interaction in terms of bone infection and regeneration. Stem Cells Translational Medicine 2019;8:1084–1091
Continuous monitoring of the dynamic behavior of a high‐rise telecommunications tower
Authors: Ribeiro Diogo , Leite Jorge , Pinto Nuno , Calçada Rui 
Published: June 2019

SummaryThis article describes the experimental evaluation of the dynamic effects induced by wind on a high‐rise telecommunications tower based on a permanent monitoring system. Monte da Virgem telecommunications tower is located near the city of Porto (Portugal), and its structure consists in a reinforced concrete shaft and a steel mast, with a total height of 177 m. The monitoring system includes accelerometers, anemometers, and a meteorological station, allowing the characterization of the maximum accelerations of the structure and wind regimes during a period of 6 months. The analysis of the results enabled identifying specific events, denominated as critical events, for which the dynamic response of the tower under wind actions appears significantly amplified due to wind aeroelastic instability phenomena in the steel mast. The automatic identification of the critical events was based on the application to the acceleration's records of an autoregressive model and estimation of its optimal order number based on a singular value decomposition. The results proved the robustness and efficiency of the proposed technique in identifying the number, duration, and maximum amplitude of accelerations associated to the critical events, envisaging its potential integration in structural health monitoring systems.
Distant Neighbors and Interscalar Contiguities
Authors: Harasim Daniel , Noll Thomas , Rohrmeier Martin 
Published: June 2019

AbstractThis paper studies the “integration” problem of nineteenth-century harmony—the question whether the novel chromatic chord transitions in this time are a radical break from or a natural extension of the conventional diatonic system. We examine the connections between the local behavior of voice leading among diatonic triads and their generalizations on one hand, and the global properties of voice-leading spaces on the other. In particular, we aim to identify those neo-Riemannian chord connections which can be integrated into the diatonic system and those which cannot. Starting from Jack Douthett’s approach of filtered point symmetries, we generalize diatonic triads as second-order Clough-Myerson scales and compare the resulting Douthett graph to the respective Betweenness graph. This paper generally strengthens the integrationist position, for example by presenting a construction of the hexatonic and octatonic cycles that uses the principle of minimal voice leading in the diatonic system. At the same time it provides a method to detect chromatic wormholes, i.e. parsimonious connections between diatonic chords, which are not contiguous in the system of second order Clough-Myerson scales.
A binned likelihood for stochastic models
Authors: Argüelles C. A. , Schneider A. , Yuan T. 
Published: June 2019

AbstractMetrics of model goodness-of-fit, model comparison, and model parameter estimation are the main categories of statistical problems in science. Bayesian and frequentist methods that address these questions often rely on a likelihood function, which is the key ingredient in order to assess the plausibility of model parameters given observed data. In some complex systems or experimental setups, predicting the outcome of a model cannot be done analytically, and Monte Carlo techniques are used. In this paper, we present a new analytic likelihood that takes into account Monte Carlo uncertainties, appropriate for use in the large and small sample size limits. Our formulation performs better than semi-analytic methods, prevents strong claims on biased statements, and provides improved coverage properties compared to available methods.
Delphi Study to Reach International Consensus Among Vascular Surgeons on Major Arterial Vascular Surgical Complications
Authors: de Mik S. M. L. , Stubenrouch F. E. , Legemate D. A. , Balm R. , Ubbink D. T. ,   the DISCOVAR Study Group, Balm R. , Becquemin J. P. , Blankensteijn J. D. , de Borst G. J. , Capoccia L. , Clair D. G. , Cronenwett J. L. , Davies A. H. , Elsman B. H. P. , Farber M. A. , Forbes T. L. , Goverde P. C. J. M. , van Herzeele I. , Hinchliffe R. J. , Jacobs D. L. , Jongkind V. , Liapis C. D. , Lönn L. , Montero‐Baker M. , Moore W. S. , Naylor A. R. , Overbeck K. , Resch T. A. , Ronchey S. , Sakalihasan N. , Sarac T. P. , Setacci C. , Sillesen H. , Veith F. J. , Verhagen H. J. , Verzini F. , Wiersema A. M. 
Published: June 2019

AbstractBackgroundThe complications discussed with patients by surgeons prior to surgery vary, because no consensus on major complications exists. Such consensus may improve informed consent and shared decision‐making. This study aimed to achieve consensus among vascular surgeons on which complications are considered ‘major’ and which ‘minor,’ following surgery for abdominal aortic aneurysm (AAA), carotid artery disease (CAD) and peripheral artery disease (PAD).MethodsComplications following vascular surgery were extracted from Cochrane reviews, national guidelines, and reporting standards. Vascular surgeons from Europe and North America rated complications as major or minor on five‐point Likert scales via an electronic Delphi method. Consensus was reached if ≥ 80% of participants scored 1 or 2 (minor) or 4 or 5 (major).ResultsParticipants reached consensus on 9–12 major and 6–10 minor complications per disease. Myocardial infarction, stroke, renal failure and allergic reactions were considered to be major complications of all three diseases. All other major complications were treatment specific or dependent on disease severity, e.g., spinal cord ischemia, rupture following AAA repair, stroke for CAD or deep wound infection for PAD.ConclusionVascular surgeons reached international consensus on major and minor complications following AAA, CAD and PAD treatment. This consensus may be helpful in harmonizing the information patients receive and improving standardization of the informed consent procedure. Since major complications differed between diseases, consensus on disease‐specific complications to be discussed with patients is necessary.