bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Mitomycin C on recurrence of plantar fibromas
Authors: Amer Kamil M. , Mohamed Sana , Amer Rami , Chaudhry Ahmed , Winters Brian , Abraham John A. 
Published: May 2018

ABSTRACTAlthough certainly not the first line treatment for plantar fibromas, surgical resection is a treatment option for some patients with have failed exhaustive non‐surgical treatment. The use of topical Mitomycin C has been recently shown to reduce the recurrence rate of other fibrous lesions. The purpose of this study was to determine the impact of topical application of Mitomycin C on recurrence rate of plantar fibromas. A retrospective analysis was done from a prospectively gathered database with a total 50 consecutive patients over a 16‐month study period. The control group (n = 29) consisted of patients who underwent only surgical resection, while the study group (n = 21) consisted of patients who underwent surgical resection with adjuvant therapy using Mitomycin C. The primary endpoint was local recurrence after the procedure. Secondary end points included complications and toxicity associated with this medication. No patients were lost to follow up. Of the 29 patients in the control group, there were 17 patients (17/29, 58.6%) had recurrence of the plantar fibroma at a mean follow‐up of 9.1 months. In contrast, in the experimental study group, all patients were free from local recurrence. No complications or side effects were associated with Mitomycin C use. The results demonstrate that the topical application of Mitomycin C to the tumor bed after surgical resection of plantar fibromas reduced the recurrence rate. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2554–2561, 2018.
Predictors of new‐onset chronic kidney disease in patients managed surgically for T1a renal cell carcinoma: An Australian population‐based analysis
Authors: Ahn Thomas , Ellis Robert J. , White Victoria M. , Bolton Damien M. , Coory Michael D. , Davis Ian D. , Francis Ross S. , Giles Graham G. , Gobe Glenda C. , Hawley Carmel M. , Johnson David W. , Marco David J. T. , McStea Megan , Neale Rachel E. , Pascoe Elaine M. , Wood Simon T. , Jordan Susan J. ,   the IMPROVE investigators
Published: May 2018

BackgroundNew‐onset chronic kidney disease (CKD) following surgical management of kidney tumors is common. This study evaluated risk factors for new‐onset CKD after nephrectomy for T1a renal cell carcinoma (RCC) in an Australian population‐based cohort.MethodsThere were 551 RCC patients from the Australian states of Queensland and Victoria included in this study. The primary outcome was new‐onset CKD (eGFR <60 mL/min per 1.73 m2) and the secondary outcome was new‐onset moderate‐severe CKD (<45 mL/min per 1.73 m2). Multivariable logistic regression was used to evaluate associations between patient, tumor and health‐service characteristics and these outcomes.ResultsForty percent (219/551) of patients developed new‐onset CKD, and 12% (68/551) experienced new‐onset moderate‐severe CKD. Risk factors for new‐onset CKD were age, lower preoperative eGFR, tumor size >20 mm, radical nephrectomy, lower hospital caseloads (<20 cases/year), and rural place of residence. The associations between rural place of residence and low center volume were a consequence of higher radical nephrectomy rates.ConclusionRisk factors for CKD after nephrectomy generally relate to worse baseline health, or likelihood of undergoing radical nephrectomy. Surgeons in rural centres and hospitals with low caseloads may benefit from formalized integration with specialist centers for continued professional development and case‐conferencing, to assist in management decisions.
Calculation of breast volumes from mammogram: Comparison of four separate equations relative to mastectomy specimen volumes
Authors: Rostas Jack W. , Bhutiani Neal , Crigger Morgan , Crawford Stacey M.W. , Hollenbach Reiss B. , Heidrich Samantha R. , Martin Robert C.G. , McMasters Kelly M. , Ajkay Nicolás 
Published: May 2018

Background and ObjectivesAccurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography‐based method of BV estimation.MethodsMammography data was obtained for patients who underwent mastectomy for breast cancer from 2005 to 2015. This data was used to calculate BV using four previously published equations. Results were compared to mastectomy specimen volumes calculated from specimen weights and breast density. Five practitioners then independently assessed reproducibility and ease of use.ResultsComplete mammographic measurements were available for 65 breasts from 45 patients. Median age was 58 years (range 19‐82). Mammographic breast density scores were available for 62 breasts. Of the 65 mastectomies performed, 16 (36%) were simple mastectomies. The equation BV = 1/3πRccRmloHmlo most closely approximated actual breast specimen volumes (R = 0.89, P < 0.0001). Internal correlation of calculated BV was excellent among all practitioners (lowest Pearson R = 0.963).ConclusionsBreast volumes can be reliably estimated utilizing measurements from a preoperative mammogram. This low‐cost method of volumetric analysis can be employed to guide surgical decision making in treatment of patients with invasive breast cancer.
Use of created snags by cavity‐nesting birds across 25 years
Authors: Barry Amy M. , Hagar Joan C. , Rivers James W. 
Published: May 2018

ABSTRACTSnags are important habitat features for many forest‐dwelling species, so reductions in the number of snags can lead to the loss of biodiversity in forest ecosystems. Intentional snag creation is often used in managed forests to mitigate the long‐term declines of naturally created snags, yet information regarding the use of snags by wildlife across long timescales (>20 yr) is lacking and prevents a complete understanding of how the value of created snags change through time. We used a long‐term experiment to assess how harvest treatment (i.e., small‐patch group selection, 2‐story, and clearcut) and snag configuration (i.e., scattered and clustered) influenced nesting in and foraging on 25–27‐year‐old Douglas‐fir (Pseudotsuga menziesii) snags by cavity‐nesting birds. In addition, we compared our contemporary measures of bird use to estimates obtained from historical surveys conducted on the same group of snags to quantify how bird use changed over time. Despite observing created snags for >750 hours across 2 consecutive breeding seasons, we found limited evidence of nesting activity. Only 11% of created snags were used for breeding, with nesting attempts by 4 bird species (n = 36 nests); however, we detected 12 cavity‐nesting species present on our study sites. Furthermore, nearly all nests (94%) belonged to the chestnut‐backed chickadee (Poecile rufescens), a weak cavity‐excavating species that requires well‐decayed wood for creating nest cavities. Our surveys also recorded few observations of birds using created snags as foraging substrates, with only 1 foraging event recorded for every 20 hours of observation. We detected 82% fewer nests and recorded 7% fewer foraging observations during contemporary field work despite spending >7.5 times more effort observing created snags relative to historical surveys. We conclude that 25–27‐year‐old created Douglas‐fir snags provided limited opportunities for nesting and foraging by most cavity‐nesting birds, and that the period of greatest use by this group occurred within 5–15 years of creation. © 2018 The Wildlife Society.
Efficiency of four different seeded plants and native vegetation as cover crops in the control of soil and carbon losses by water erosion in olive orchards
Authors: Repullo‐Ruibérriz de Torres Miguel A. , Ordóñez‐Fernández Rafaela , Giráldez Juan V. , Márquez‐García Javier , Laguna Ana , Carbonell‐Bojollo Rosa 
Published: May 2018

AbstractSoil erosion is intense on steep slopes, where many olive orchards are located in Mediterranean areas. The adoption of cover crops is a promising soil and water conservation practice for these areas. Nevertheless, there has not been enough information to be able to advise farmers on the selection of plant species. The purpose of this report is to assess different plant species as cover crops to reduce erosion and soil organic carbon loss through sediments. Twenty‐four tests were performed in 6 plots on a 20% slope in southern Spain. A gramineous plant (Brachypodium distachyon), 2 leguminous species (Vicia sativa and Vicia ervilia), and a cruciferous plant (Sinapis alba) were sown and compared with spontaneous vegetation and conventional tillage. Simulated rainfall with intensities of 18.1 (±1.6) and 38.8 (±2.3) mm hr−1 was applied during 2 years. All cover crop treatments, in comparison with tillage, significantly reduced soil and soil organic carbon losses by more than 92%, S. alba being the species with the lowest runoff values. The high rate of soil and water losses observed in the tillage treatment emphasizes the need to protect the soil and its fertility. A kinematic wave model considering variable soil infiltration rates was fitted to the runoff data to evaluate relevant soil and surface characteristics. The estimated saturated hydraulic conductivity and length of the capillary scale were not affected by the treatments, but the surface resistance to water flow indicated the efficiency of S. alba, B. distachyon, and V. ervilia in reducing the runoff velocity.
The effects of anticipated goal‐inconsistent behavior on present goal choices
Authors: Zemack‐Rugar Yael , Corus Canan 
Published: May 2018

AbstractPrior work has examined how, in the pursuit of long‐term goals, past goal behavior influences present goal choices. Instead, the present work focuses on how anticipating future goal behavior, specifically future goal‐inconsistent behavior, influences present goal choices. For example, how anticipating overspending on an upcoming vacation influences current spending behavior. The authors propose that the effect of anticipated goal‐inconsistent behavior on present goal choice is moderated by the perceived changeability of the future behavior. When future goal‐inconsistent behavior is perceived as changeable, consumers tend to imagine it away, and it has no systematic effect on present goal choices. However, when future goal‐inconsistent behavior is perceived as unchangeable, consumers accept it as a matter of fact, and systematic effects occur. Specifically, some consumers not only fail to buffer against future goal‐inconsistent behavior's negative consequences, but tend to exacerbate those consequences by increasing their goal‐inconsistent behavior in the present. Four studies examine this surprising behavior, using an individual difference (the response‐to‐failure scale) to identify when and for whom it occurs. The studies demonstrate the role of perceived changeability using various manipulations across multiple critical goal domains such as spending, eating, and academics.
CDPBC: A Software Application for Estimation of Concentration Dependent Plasma Binding Capacity of Small Molecule
Authors: Prakash Om , Dwivedi Upendra Nath 
Published: May 2018

AbstractDrug‐plasma binding (DPB) is an important aspect during pharmacokinetics (PK) studies. DPB of small molecule cannot be evaluated through computational means. Here we present CDPBC; a standalone application for evaluation of small molecule for its capacity (concentration dependent) of binding with plasma proteins. This application is freely available at URL (https://github.com/undwive di/CDPBC.git). The application is enriched with evaluation of five major proteins of plasma. Input for application is a docked complex against the suggested PDBs of plasma proteins. As part of the analysis, software compares interaction of query compound with control compound. Main output comes as plot as well as table displaying percentage of binding in reference of concentration gradient of small molecule used in docking. The application is an advanced add‐on component to ADME analysis of small molecules as well as lead optimization.
Myasthenic ophthalmoparesis: Time To resolution after initiating immune therapies
Authors: Europa Tarin A. , Nel Melissa , Heckmann Jeannine M. 
Published: May 2018

ABSTRACTIntroduction: Although immunotherapies such as prednisone are effective in treating myasthenic muscle weakness, their effect on resolution of myasthenic‐induced persistent ophthalmoparesis is unknown. Methods: We observed patients with myasthenia gravis during their first year of immunotherapy, documenting ophthalmoplegia scores and drug doses. Results: Seventy‐six of 87 cases had persistent ophthalmoparesis. With immunotherapy, the median time to resolution of ophthalmoparesis was 7 months, and 37% of cases resolved within 3 months. Patients starting therapy within 12 months of symptom onset were twice as likely to have resolution in the first year (P = 0.028). Resolution of ophthalmoparesis within 3 months, compared with later resolution, was associated with higher initial prednisone doses (mean 0.5 vs. 0.3 mg/kg/day; P = 0.014). However, 25% of the higher dose group also received intravenous immunoglobulin/plasma exchange; after their exclusion, the finding was not significant. Discussion: One‐third of cases with myasthenic ophthalmoparesis resolved within 3 months of immunotherapy, particularly in response to more aggressive immunotherapy. Muscle Nerve 58: 542–549, 2018
A direct design method of controllers based on the frequency response indices for servo systems
Authors: Chen Songlin , Chen Ting , Ma Kemao , He Zongru , Yao Yu 
Published: May 2018

SummaryTo improve the design efficiency of servo systems, a novel controller design method is proposed based on the desired closed‐loop transfer functions satisfying the required frequency response indices. Taking into account the constraint due to the physical realizability of controllers, the desired closed‐loop transfer functions are specified. In addition, the analytical expressions for certain kinds of performance indices and design constraints, including dual‐ten indices of frequency responses, crossover frequency, phase margin, and magnitude margin, are derived. Then, the principles for controller parameter determination are discussed. The controller design is formulated as an optimal problem with a variety of constraints, and the design guidelines are presented. At last, experiments are conducted to verify the effectiveness of the proposed method.
Minimal Information About an Immuno‐Peptidomics Experiment (MIAIPE)
Authors: Lill Jennie R. , van Veelen Peter A. , Tenzer Stefan , Admon Arie , Caron Etienne , Elias Joshua E. , Heck Albert J.R. , Marcilla Miguel , Marino Fabio , Müller Markus , Peters Bjoern , Purcell Anthony , Sette Alessandro , Sturm Theo , Ternette Nicola , Vizcaíno Juan Antonio , Bassani‐Sternberg Michal 
Published: May 2018

AbstractMinimal information about an immuno‐peptidomics experiment (MIAIPE) is an initiative of the members of the Human Immuno‐Peptidome Project (HIPP), an international program organized by the Human Proteome Organization (HUPO). The aim of the MIAIPE guidelines is to deliver technical guidelines representing the minimal information required to sufficiently support the evaluation and interpretation of immunopeptidomics experiments. The MIAIPE document has been designed to report essential information about sample preparation, mass spectrometric measurement, and associated mass spectrometry (MS)‐related bioinformatics aspects that are unique to immunopeptidomics and may not be covered by the general proteomics MIAPE (minimal information about a proteomics experiment) guidelines.
Pediatric pulmonology year in review 2017: Part 1
Authors: Gower William A. , Birnkrant David J. , Black Jane B. , Nicolai Thomas , Noah Terry L. 
Published: May 2018

AbstractPediatric Pulmonology publishes original research, case reports and review articles on topics related to a wide range of children's respiratory disorders. In this article (Part 1 of a series), we summarize the past year's publications in our major topic areas, as well as selected literature in these areas from other journals. In Part 1, we review selected articles on diagnostic testing/endoscopy, respiratory complications of neuromuscular disorders, and rare lung diseases.
Potential pathogenicity of Inquilinus limosus in a pediatric patient with cystic fibrosis
Authors: Poore T. Spencer , Virella‐Lowell Isabel , Guimbellot Jennifer S. 
Published: May 2018

AbstractPresentationPatient is a 6‐year‐old male with CF, MRSA colonization, and pancreatic insufficiency that presented with worsening ppFEV1 and systemic symptoms despite multiple interventions. BAL grew NTM, Stenotrophomonas maltophilia, and Inquilinus limosus, a rare organism found in patients with CF.CourseI. limosus treatment was deferred. Despite treatment of other pathogens, symptoms worsened. I. limosus was targeted with meropenem, amikacin, and ciprofloxacin along with clindamycin for MRSA colonization. Within weeks, symptoms had resolved with ppFEV1 improvement.DiscussionThis case discusses the importance of a rare organism in the CF population. Targeting I. limosus was key to recovery, revealing its potential pathogenicity.
N‐terminal‐probrain natriuretic peptide as a biomarker of moderate to severe bronchopulmonary dysplasia in preterm infants: A prospective observational study
Authors: Rodríguez‐Blanco Silvia , Oulego‐Erroz Ignacio , Alonso‐Quintela Paula , Terroba‐Seara Sandra , Jiménez‐González Aquilina , Palau‐Benavides Maite 
Published: May 2018

AbstractObjectiveN‐terminal‐probrain natriuretic peptide (NT‐proBNP) is a marker of hemodynamically significant patent ductus arteriosus (HsPDA) in preterm infants. In this study, we assessed whether NT‐proBNP levels could predict the risk of moderate to severe bronchopulmonary dysplasia (BPD) and/or death.MethodsThis was an observational prospective study of preterm infants with GA ≤32 weeks. Infants who died within the first 48 h or who had major congenital malformations or incomplete information were excluded. NT‐proBNP was determined at 48‐96 h of life and at 5‐10 days of life. The predictive capacity of NT‐proBNP for the combined outcome of BPD and/or death was evaluated using receiver operator characteristic (ROC) curves and multivariate regression.ResultsOf the 125 eligible patients, 110 completed the analysis. Twenty‐eight developed BPD (n = 15) and/or died (n = 13). Infants who developed BPD and/or died had higher NT‐proBNP levels ​​at 48‐96 h (26,848 ng/L, interquartile range [IQR] 7818‐60,684 vs 3008 ng/L, IQR 1425‐9876) and at 5‐10 days (8849 ng/L, IQR 3796‐19,526 vs 1427 ng/L, IQR 907‐2889). The NT‐proBNP levels at 5‐10 days, but not at 48‐96 h, were independently associated with BPD and/or death after adjustments for HsPDA and other confounders (OR = 3.36; 95%CI: 1.52‐7.4, P = 0.006). For the prediction of this result, a cutoff of 3348 ng/L had a sensitivity and specificity of 82% and 83%, respectively (area under the curve [AUC] = 0.87; 95%CI: 0.79‐0.95).ConclusionThe NT‐proBNP levels at 5‐10 days of life may identify preterm infants with an HsPDA who are at high risk of BPD or death and may be useful for individualized preventive and therapeutic strategies.
Reference equations for the interpretation of forced expiratory and plethysmographic measurements in infants
Authors: Lu Zihang , Foong Rachel E. , Kowalik Krzysztof , Moraes Theo J. , Dubeau Aimee , Lefebvre Diana , Davis Stephanie D. , Balkovec Susan , Becker Allan , Mandhane Piush , Turvey Stuart E. , Lou Wendy , Sears Malcolm R. , Ratjen Felix , Subbarao Padmaja 
Published: May 2018

AbstractBackgroundPulmonary function testing is commonly performed for diagnosis and clinical management of respiratory diseases. It is important to use appropriate reference equations from healthy subjects for interpretation of data from infants with lung disease. This study aimed to determine if published reference equations were similar to forced flow measures and plethysmographic infant pulmonary function testing data collected in the Canadian Healthy Infant Longitudinal Development (CHILD) Study.MethodsReference equations for five pulmonary function variables (FEV0.5, FVC, FEF25‐75, FEV0.5/FVC ratio and plethysmography (FRCpleth)) were developed using data from the nSpire system. New reference equations developed using healthy data from the CHILD Study were compared to previously published reference equations for forced flow and plethysmographic measures.ResultsThe current analysis included 131 infants (on 181 test occasions) with forced flow measures and 161 infants (on 246 test occasions) with plethysmography measures, aged 3–24 months. Age and length were major determinants of both forced flow and plethysmography measures. In addition, ethnicity (Caucasian vs non‐Caucasian) was significantly associated with FEV0.5/FVC and FEF25‐75 measures. We found that the published reference equations based on custom‐built equipment or commercially available systems provided poor fit to our current pulmonary function testing data, resulting in placing a large proportion of our healthy population outside the normal ranges.ConclusionsOur current data support the need for population and device specific reference data for infant pulmonary function studies. By deriving new equipment‐specific reference equations for our healthy population, we provide normative data to other centers utilizing this equipment.
The identification of a novel antibody for CD133 using human antibody phage display
Authors: Glumac Paige M. , Forster Colleen L. , Zhou Hong , Murugan Paari , Gupta Shilpa , LeBeau Aaron M. 
Published: May 2018

BackgroundThe transmembrane glycoprotein CD133 is believed to be a marker of adult prostate stem cells and cancer stem/initiating cells. Investigating the role of CD133 in the normal biology of the prostate and in cancer is complicated by the lack of a sensitive and accurate antibody for its detection. Here, we describe the characterization of a unique antibody identified using human antibody phage display that can recognize CD133 in both formalin‐fixed tissues and cell lines.MethodsA human single‐chain variable fragment (scFv) antibody phage display library possessing a diversity of 8 × 109 was screened against fully glycosylated recombinant CD133. A counter screen was performed against deglycosylated CD133 to select for clones that preferentially recognized a glycosylation‐independent epitope. The lead scFv was analyzed by flow cytometry and cloned into a rabbit immunoglobulin scaffold for immunohistochemistry (IHC).ResultsThe antibody designated HA10 was found to bind a glycosylation‐independent epitope on the peptide backbone of CD133 with high affinity. As a reagent for flow cytometry, HA10 detected CD133 more accurately than a commonly used commercially available antibody. IHC analysis with HA10 documented the staining of basal cells and luminal cells in healthy prostate sections. Weak staining of luminal cells was observed in adenocarcinoma sections at a very low frequency. Examination of a LuCaP patient‐derived xenograft tissue microarray found that only three of the LuCaP models were positive for CD133. The three CD133pos LuCaP models all originated from non‐AR driven metastatic prostate cancer with neuroendocrine differentiation. Subsequent interrogation of liver biopsies from a patient who failed second‐generation anti‐androgen therapy found high levels of CD133 staining. The original transurethral resection of the prostate from that patient was, however, absent of CD133.ConclusionsWe have developed a novel antibody that was able to detect CD133 by both IHC and flow cytometry. Using HA10 as an IHC reagent, we found that CD133 is a marker for a very rare cell type in both healthy prostate and adenocarcinoma sections. Our preliminary investigation also suggests that there may be an association between CD133 and non‐AR driven prostate cancer with neuroendocrine differentiation.