bluuebunny/crossref_metadata_2025_split huggingface dataset:
Room 4 Birth - The effect of an adaptable birthing room on labour and birth outcomes for nulliparous women at term with spontaneous labour start: study protocol for a randomised controlled superiority trial in Sweden
Authors: Berg Marie , Goldkuhl Lisa , Nilsson Christina , Wijk Helle , Gyllensten Hanna , Lindahl Göran , Moberg Kerstin Uvnäs , Begley Cecily 
Published: August 2019

Abstract
Background: An important prerequisite for optimal healthcare is a secure, safe and comfortable environment. There is little research on how the physical design of birthing rooms affects labour, birth, childbirth experiences, and birthing costs. This protocol outlines the design of a randomised controlled superiority trial (RCT) measuring and comparing effects and experiences of two types of birthing rooms, conducted in one labour ward in Sweden.
Methods/Design: Following ethical approval, a study design was developed and tested for feasibility in a pilot study which led to some important improvements for the conduction of the study. The main RCT started January 2019 and includes nulliparous women presenting to the labour ward in active, spontaneous labour, who understand either Swedish, Arabic, Somali or English. Those who consent are randomised on a 1:1 ratio to receive care either in a regular room (control group) or in a newly built birthing room designed with a person-centered approach and physical aspects (such as: light, silencer, media installator offering programmed nature scenes with sound, bath tub, birth support tools) that are adaptable as a woman wishes (intervention group). The primary efficacy endpoint is a composite score of four outcomes: no use of oxytocin for augmentation of labour; spontaneous vaginal births (i.e. no vaginal instrumental birth or caesarean section); normal postpartum blood loss (i.e. bleeding <1000 ml.); and a positive overall childbirth experience (7-10 on a scale 1-10). To detect a difference in the composite score of 8% between the groups we need 1274 study participants (power of 80% with significance level 0.05). Secondary outcomes include: other physical outcomes of labour and birth; women´s selfreported experiences (the birthing room, childbirth, fear of childbirth, health-related quality of life), and measurement of costs in relation to the hospital stay for mother and neonate. Additionally, an ethnographic study with participant observations will be conducted in both types of birthing rooms.
Discussion: The findings aim to guide the design of birthing rooms that contribute to optimal quality of hospital-based maternity care.
Manual therapy as a prophylactic treatment for migraine. Design of a randomized controlled trial.
Authors: Amons Andreas Leonard , Castien Rene Franciscus , Wouden Johannes van der , De Hertogh Willem , Dekker Joost , Horst Henriëtte Eveline van der 
Published: August 2019

Abstract
Background: People with migraine often experience disability with serious consequences for social life and work productivity. The effectiveness of pharmacological prophylactic management of migraine is limited, leading to a demand for non-pharmacological treatment options. We present the design and discuss the feasibility of a pragmatic, randomized controlled trial on the effectiveness of a multimodal manual therapy (MT) treatment compared to usual care by the general practitioner (GP) for the prophylactic treatment of migraine. Methods: Eligible participants will be recruited in primary care using the International Classification of Headache Disorders III criteria for migraine of the International Headache Society. Participants will be randomized to either multimodal MT treatment or usual care provided by the GP. GPs will be asked to treat the usual care group according to the Dutch GP guideline for headache. The multimodal MT intervention will include manual pressure techniques, neck muscle-strength exercises, and mobilization of the cervical and thoracic spine. The trial will consist of a 12 weeks treatment period and follow-up measurements at 12, 26 and 52 weeks. The primary outcome measure is the number of migraine days per four weeks, assessed with a headache diary. Secondary outcome measures are the number of migraine attacks, medication use, disability due to headache, headache intensity, number of participants reporting a 50% migraine reduction, measurement of cervical pressure pain thresholds, presence of allodynia, endurance of cervical flexor muscles, days of absence of work and global perceived effect. Discussion: The results of the trial will show if a multimodal MT intervention is an effective non-pharmacological treatment option for people with migraine. Trial registration: 7 February 2019 Dutch Trial Register (NL7504)
Statistical analysis plan (SAP) for the 5- and 10-year follow-up assessments of the FIDELITY trial
Authors: Sihvonen Raine , Kalske Roope , Englund Martin , Turkiewicz Aleksandra , Toivonen Pirjo , Taimela Simo , Järvinen Teppo 
Published: August 2019

Abstract
Background

The research objectives of the 5- and 10-year assessments of the Finnish Degenerative Meniscal Lesion Study (FIDELITY) are two-fold: 1) to assess the long-term efficacy of arthroscopic partial meniscectomy (APM) in adult (age 35 to 65 years) patients with a degenerative meniscus tear, and 2) to determine the respective effects of APM and degenerative meniscus tear on the development of radiographic and clinical knee osteoarthritis (OA).

Methods and Design

FDELITY is an ongoing multi-centre, randomized, participant and outcome assessor blinded, placebo-surgery controlled trial of 146 patients. This statistical analysis plan (SAP) article describes the overall principles for analysis of long-term outcomes (5- and 10-year follow-ups), including how participants will be included in each analysis, the primary and secondary outcomes and their respective analyses, adjustments for covariates, and the presentation of the results. In addition, we will present the planned sensitivity and subgroup analyses.
Using digital tools in the recruitment and retention in randomised controlled trials: Survey of UK Clinical Trial Units and a qualitative study
Authors: Blatch-Jones Amanda Jane , Nuttall Jacqueline , Bull Abby , Worswick Louise , Mullee Mark , Peveler Robert , Falk Stephen , Tape Neil , Hinks Jeremy , Lane Athene J , Wyatt Jeremy C , Griffiths Gareth 
Published: August 2019

Abstract
Background

Recruitment and retention of participants in Randomised Controlled Trials (RCTs) is a key determinant of success, but is challenging. Trialists and UK Clinical Research Collaboration (UKCRC) Clinical Trials Units (CTUs) are increasingly exploring the use of digital tools to identify, recruit and retain participants. The aim of this UK National Institute for Health Research (NIHR) study was to identify what digital tools are currently used by CTUs and understand the performance characteristics required to be judged useful.

Methods

A scoping of searches (and a survey with NIHR funding staff), a survey with all 52 UKCRC CTUs and 16 qualitative interviews were conducted with five stakeholder groups including trialists within CTUs, funders and research participants. A purposive sampling approach was used to conduct the qualitative interviews during March-June 2018. Qualitative data were analysed using a content analysis and inductive approach.

Results

Responses from 24 CTUs (46%) identified that database-screening tools were the most widely used digital tool for recruitment, with the most frequent reported success criteria being saving General Practitioner time and reaching more patients. Fewer retention tools were used, with Short Message Service (SMS) or email reminders to participants being the most reported. The qualitative interviews revealed five themes across all groups: ‘security and transparency’, ‘inclusivity and engagement’, ‘human interaction’, ‘obstacles and risks’ and ‘potential benefits’. There was a high level of stakeholder acceptance of the use of digital tools to support trials, despite the lack of evidence to support them over more traditional techniques. Certain differences and similarities between stakeholder groups demonstrated the complexity and challenges of using digital tools for recruiting and retaining research participants.

Conclusions

Our studies identified a range of digital tools in use in recruitment and retention of RCTs, despite the lack of high quality evidence to support their use. Understanding the type of digital tools in use to support recruitment and retention will help to inform funders and the wider research community about their value and relevance for future RCTs. Consideration of further focused digital tool reviews and primary research will help to reduce gaps in the evidence base.
Pentingnya Kecerdasan Emosi dan Spiritual terkait Isu Sensitivitas Etika Auditor (Studi Kasus pada Internal Auditor BNI Syariah)
Authors: Istiariani Irma 
Published: August 2019

Auditing and ethical sensitivity research in the academic area has often done, but these research is seldom done on the syaria banking sector, like Syaria BNI with the respondence is internal auditor. The central issue in this research is the author want to show empirically how matter important the EQ and ESQ toward ethical sensitivity and whether an inconsistence with the previous research. The method used literature research to explore the data. The results indicated that ethical sensitivity the internal auditor in Syaria BNI had linked with emotional and spiritual intelligence. Practical implications indicate the importance of emotional and spiritual intelligence that is closely related to the ethical sensitivity auditor conducted by internal auditor Syaria BNI.Penelitian audit dan sensitivitas etika di bidang akademik sudah sering dilakukan, tetapi penelitian ini jarang dilakukan pada sektor perbankan syariah, seperti syariah BNI dengan responden adalah auditor internal. Isu sentral yang terdapat di dalam riset ini adalah penulis ingin menunjukkan secara empiris seberapa penting kualitas kecerdasan emosional dan spiritual terhadap sensitivitas etika. Metode yang digunakan di dalam penelitian ini studi literatur sebagai alat untuk memperoleh sumber data. Hasil dari penelitian ini adalah tingkat sensitivitas etika internal di BNI syariah memiliki hubungan yang kuat dengan kualitas kecerdasan emosional dan spiritual. Implikasi praktis dari penelitian ini menunjukkan pentingnya kualitas kecerdasan emosional dan spiritual yang erat kaitannya dengan tingkat sensitivitas etika auditor internal BNI syariah.
An Integrative Gene Expression Microarray Meta-analysis Identifies Host Factors and Key Signatures Involved in Hepatitis B Virus Infection
Authors: Elmessaoudi-Idrissi Mohcine , Windisch Marc P. , Kettani Anass , Altawalah Haya , Pineau Pascal , Benjelloun Soumaya , Ezzikouri Sayeh 
Published: August 2019

:
>Hepatitis B virus (HBV) is a global health concern. Viral and host factors orchestrate
the natural history of HBV infection, but the impact of host factors that influence the clinical
course of the disease remains poorly understood. The aim of this study was to identify host factors
crucial to the HBV life cycle by conducting a meta-analysis utilizing public microarray datasets.

Methods:
An integrative meta-analysis of expression data from two microarray datasets of HBVinfected
liver tissues and healthy uninfected livers was conducted to identify gene expression signatures
and overlapping biological processes modulating infection/disease.

Results:
Using integrative meta-analysis of expression data (INMEX), we identified across two
datasets a total of 841 genes differentially expressed during HBV infection, including 473 upregulated
and 368 downregulated genes. In addition, through functional enrichment and pathway
analysis, we observed that Jak-STAT, TLR, and NF-κB are the most relevant signaling pathways
in chronic HBV infection. The network-based meta-analysis identified NEDD8, SKP2, JUN, and
HIF1A as the most highly ranked hub genes.

Conclusion:
Thus, these results may provide valuable information about novel potential host factors
modulating chronic HBV infection. Such factors may serve as potential targets for the development
of novel therapeutics such as activin receptor-like kinase inhibitors.
Formononetin Ameliorates Cognitive Disorder via PGC-1α Pathway in Neuroinflammation Conditions in High-Fat Diet-Induced Mice
Authors: Fu Xinxin , Qin Tingting , Yu Jiayu , Jiao Jie , Ma Zhanqiang , Fu Qiang , Deng Xueyang , Ma Shiping 
Published: August 2019

Background:
Alzheimer’s disease is one of the most common neurodegenerative diseases
in many modern societies. The core pathogenesis of Alzheimer’s disease includes the aggregation of
hyperphosphorylated Tau and abnormal Amyloid-β generation. In addition, previous studies have
shown that neuroinflammation is one of the pathogenesis of Alzheimer’s disease. Formononetin, an
isoflavone compound extracted from Trifolium pratense L., has been found to have various properties
including anti-obesity, anti-inflammation, and neuroprotective effects. But there are very few studies
on the treatment of Alzheimer’s disease with Formononetin.

Objective:
The present study focused on the protective activities of Formononetin on a high-fat dietinduced
cognitive decline and explored the underlying mechanisms.

Methods:
Mice were fed with HFD for 10 weeks and intragastric administrated daily with metformin
(300 mg/kg) and Formononetin (20 and 40 mg/kg).

Results:
We found that Formononetin (20, 40 mg/kg) significantly attenuated the learning and memory
deficits companied by weight improvement and decreased the levels of blood glucose, total cholesterol
and triglyceride in high-fat diet-induced mice. Meanwhile, we observed high-fat diet significantly
caused the Tau hyperphosphorylation in the hippocampus of mice, whereas Formononetin reversed
this effect. Additionally, Formononetin markedly reduced the levels of inflammation cytokines IL-1β
and TNF-α in high-fat diet-induced mice. The mechanism study showed that Formononetin suppressed
the pro-inflammatory NF-κB signaling and enhanced the anti-inflammatory Nrf-2/HO-1 signaling, which
might be related to the regulation of PGC-1α in the hippocampus of high-fat diet -induced mice.

Conclusion:
Taken together, our results showed that Formononetin could improve the cognitive function
by inhibiting neuroinflammation, which is attributed to the regulation of PGC-1α pathway in
HFD-induced mice.
Counseling Teacher Quality Improvement: Upaya Meningkatkan Kualitas Hubungan Siswa dan Guru
Authors: Ramdhani Neila 
Published: August 2019

This article encompasses two studies about the influence of Counseling Teacher Quality Improvement (CTQI) Program in improving the competence of guidance and counseling teacher. The first study evaluated the effectiveness of CTQI in changing students and headmaster’s perceptions toward the way guidance and counseling teacher facilitates students in managing their problems. The second study aimed to examine the increase of guidance and counseling teacher’s counseling self-efficacy after participating in the three months counseling assistance program. Participants were 59 guidance and counseling teachers, 59 student groups, and 59 headmasters. Guidance and counseling teacher’s self-perception scale was given to teachers, perception toward teacher scale was given to headmasters and students. Counseling self-efficacy scale was only given to teachers. Data analysis showed that the perception of teachers, headmasters, and students increased after teachers parttook in CTQI. Improvement also occured in counseling self-efficacy after counseling assistance program. However, headmasters’ perception toward guidance and counseling teachers’ counseling self-efficacy remained unchanged.
Strengths and Difficulties Questionnaire Parent Report (SDQ-PR) As Screening Instrument of Children Mental Health in Indonesia
Authors: Wimbarti Supra , Siregar Juliarni , Oktaviana Mistety , Regiastri Regiastri 
Published: August 2019

This study aims at examining the agreement level between clinical diagnoses by a senior psychologist in the hospital and diagnoses/screening on Strengths and Difficulties Questionnaire conducted by parents. Using ICD 10 (Indonesian version) as the gold standard, a clinical child psychologist diagnosed 253 male and female elementary school children aged 7-14 years old. Parents of the same children were requested to fill-out the SDQ questionnaire (SDQ-PR). Psychometric property of SDQ-PR was analyzed using Alpha Cronbach and Principal Axis Factoring Analysis. Screening quality of SDQ-PR was examined using Receiver Operating Characteristic (ROC), Likelihood Ratio (LR+ and LR-), and Chi-square. Reliabilities of SDQ-PR in all subscales were (α = 0.562 to α = 0.684) except subscale of peer-problem (α = 0.174). Different from the original version of SDQ-PR that consists of 5 subscales, this study revealed 8 subscales. LR and ROC analyses for hyperkinetic revealed LR+ = 1.84 and LR– = 0.51, sensitivity = 67.6% and specificity = 63.3% with cut-off score ≥ 6. For behavior disorder, the LR+ = 2.3, LR- = 0.42, sensitivity = 70.96%, and specificity = 69.15% with cut-off score ≥ 4. As for behavior disorder the LR+ = 1.07, LR- = 0.94, sensitivity = 50%, specificity 53.27% with cut-off score ≥ 4. Chi-square score indicated a significant correlation between SDQ-PR and the diagnoses from child psychologist for hyperkinetic and behavior disorder, but not for an emotional problem.
The Environmental effects on fortified palm olein in the Anthropocene
Authors: Pradipta Adia Nuraga Galih , Andayani Sukmo Wening , Yulyianti Dewi , Jayanti Latifun , Silalahi Dewi Kristina Natalia , Christianti Isti , Mulyono Karyanto , Wassell Paul 
Published: August 2019

Until now, no literature exists to explain about the impact of time, and environmental parameters, when using typical commercial grade transparent linear low density polyethylene (LLDPE) packaging for protecting vegetable cooking oil during typical shelf-life conditions. We tested long-term impact of temperature and illuminance (light: 100 to 150 lux and darkness <1 lux) on refined bleached deodorized palm olein (RBDPOL), fortified with vitamin A. Results showed degradation of fortified RBDPOL with 70 ppm vitamin A was approximately 15% at 18-22oC in Light, 10% at 18-22oC in Darkness, 19% at 32-33oC in light and 17% 32-33oC in darkness. Similar trend was observed at 45 ppm vitamin A. Exposure to heat and light impacted vitamin A degradation, but is primarily attributed to temperature, irrespective of packaging. This investigation builds on our previous work (Silalahi et al., 2017), and confirms the impact of challenging environmental conditions on vegetable cooking oil shelf-life over long time periods.
Livro Didático de Ensino Médio, Geometria e a Presença das Tecnologias
Authors: Barcelos Amaral-Schio Rúbia 
Published: August 2019

O presente texto é fruto de uma pesquisa em andamento, que dentre seus objetivos está a análise da integração das tecnologias aos livros didáticos de Matemática. A pesquisa é de cunho qualitativo e visa instigar a reflexão sobre as contribuições de diferentes recursos didáticos (tecnologias digitais em particular) às práticas dos professores com livros didáticos. Neste artigo o foco é apresentar parte dos resultados, advindos da análise de atividades de cinco coleções de livros didáticos do Ensino Médio no âmbito das propostas de uso das tecnologias no desenvolvimento de conteúdos de Geometria. Os resultados apontam a pouca presença das tecnologias digitais nos livros do Ensino Médio, sendo raras as atividades que apresentam questões de investigação, de exploração visual de figuras geométricas, e de utilização de softwares de geometria dinâmica, que abordam aspectos do dinamismo desse recurso. A maioria delas se limita à realização e conferência de cálculos. Espera-se que haja uma mudança desse quadro, uma vez que desde 2014 Objetos Educacionais Digitais têm sido incorporados aos livros didáticos, com a proposta de haver uma maior integração das tecnologias ao tradicional recurso impresso que o professor usa para desenvolvimento de suas aulas.
Simulador de Realidade Virtual Aplicado à Educação Patrimonial para Experiências Imersivas Gamificadas
Authors: Rodrigues Batista Huoston , Ricardo Batista Mesquita Paulo , Antonio Gaspar Marcos 
Published: August 2019

O objetivo deste trabalho é apresentar o desenvolvimento de um simulador de realidade virtual para experiências imersivas gamificadas aplicado à educação patrimonial, que adotou como objeto de interesse o complexo conhecido como ‘Fábrica de Sal’ em Ribeirão Pires (SP). O desenvolvimento do simulador contemplou quatro etapas: pesquisa documental, levantamento fotográfico, reconstrução digital dos espaços e programação do simulador. A solução desenvolvida foi validada por profissionais de Educação e do Patrimônio, tendo sido testada por crianças em idade escolar do Ensino Fundamental. Foi possível perceber o potencial da solução desenvolvida para a criação de experiências imersivas aplicadas à educação patrimonial. O resultado contribui para a combinação da Realidade Virtual e gamificação como ferramenta educacional.
PlanetARio – Uso da Real idade Aumentada para Apoiar o Ensino do Sistema Solar
Authors: Henrique da Silva Ferreira Paulo , Roberto Zorzal Ezequiel 
Published: August 2019

Este trabalho apresenta uma aplicação de Realidade Aumentada voltada paraapoiar o ensino de conteúdos relacionados ao Sistema Solar, principalmente emsituações onde a visualização da diferença de tamanho entre os corpos celestes éimportante. A aplicação possui três experimentos para apoiar o ensino: escala doscorpos celestes do Sistema Solar; animação referente à translação e rotação do Sistema Solar e; a apresentação, em tempo real, das informações referentes ao clima do planeta Terra. A aplicação foi utilizada por alunos do 5º ano do Ensino Fundamental e apresentou resultados positivos no teste de usabilidade efetuado. A aplicação está disponível gratuitamente e pode ser executada em smartphones ou tablets utilizando apenas o navegador nativo de Internet.
A Epistemologia Genética em um Experimento Virtual Imersivo 3D de Magnetismo
Authors: A. Ferreira Valter , C. Nicolete Priscila , M. R. Tarouco Liane , Becker Fernando 
Published: August 2019

Este trabalho trata do desenvolvimento de um experimento virtual imersivo 3D de magnetismo elaborado na plataforma OpenSim. A fundamentação teórica encontra-se na Epistemologia Genética, a coleta de dados inspirou-se no Método Clínico de Piaget e a análise foi realizada com base nos estudos de Piaget e Inhelder sobre o pensamento do adolescente. Os dados foram obtidos pela gravação audiovisual da apliação da entrevista clínica ao longo das simulações virtuais. Os resultados demonstraram a viabilidade da criação de experimentos virtuais imersivos 3D de magnetismo sob a ótica da teoria de Piaget, além de apontar para o uso do pensamento formal por parte dos sujeitos entrevisados.
O uso da computação desplugada em um contexto de gamificação para o ensino de estrutura de dados
Authors: Adolfo Moreira Jussara , Marques Monteiro Willmara 
Published: August 2019

Nos dias atuais se faz ainda mais necessário o uso de novas metodologias para que a aprendizagem dos alunos se torne mais significativa. Estamos diante de uma geração rodeada por tecnologias e que constrói o seu aprendizado de maneira diferenciada. Este artigo tem por objetivo apresentar um relato de experiência na reformulação da disciplina Estrutura de Dados em um curso de computação, usando gamificação e computação desplugada para motivar e simplificar conceitos, para obter aprendizagem significativa. Os resultados apontam que o uso de tais metodologias proporcionou melhorias no aprendizado dos alunos. Conclui-se que o uso de tais métodos de ensino é essencial para atrair a atenção dos discentes e ainda criar estratégias para o ensino de conteúdos considerados complexos, como linguagens de programação.