bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting cellular metabolism to reduce head and neck cancer growth
Authors: Yang Jian , Guo Yuqi , Seo Wonkyu , Zhang Ruohan , Lu Cuijie , Wang Yaoyu , Luo Liang , Paul Bidisha , Yan Wenbo , Saxena Deepak , Li Xin 
Published: March 2019

AbstractHead and neck squamous cell carcinoma (HNSCC) presents a major public health concern because of delayed diagnosis and poor prognosis. Malignant cells often reprogram their metabolism in order to promote their survival and proliferation. Aberrant glutaminase 1 (GLS1) expression enables malignant cells to undergo increased glutaminolysis and utilization of glutamine as an alternative nutrient. In this study, we found a significantly elevated GLS1 expression in HNSCC, and patients with high expression levels of GLS1 experienced shorter disease-free periods after therapy. We hypothesized that the GLS1 selective inhibitor, bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES), which curtails cells’ glutamine consumption, may inhibit HNSCC cell growth. Our results support the idea that BPTES inhibits HNSCC growth by inducing apoptosis and cell cycle arrest. Considering that metformin can reduce glucose consumption, we speculated that metformin would enhance the anti-neoplasia effect of BPTES by suppressing malignant cells’ glucose utilization. The combination of both compounds exhibited an additive inhibitory effect on cancer cell survival and proliferation. All of our data suggest that GLS1 is a promising therapeutic target for HNSCC treatment. Combining BPTES with metformin might achieve improved anti-cancer effects in HNSSC, which sheds light on using novel therapeutic strategies by dually targeting cellular metabolism.
Capacitive technologies for highly controlled and personalized electrical stimulation by implantable biomedical systems
Authors: Soares dos Santos Marco P. , Coutinho J. , Marote Ana , Sousa Bárbara , Ramos A. , Ferreira Jorge A. F. , Bernardo Rodrigo , Rodrigues André , Marques A. Torres , Cruz e Silva Odete A. B. da , Furlani Edward P. , Simões José A. O. , Vieira Sandra I. 
Published: March 2019

AbstractCosurface electrode architectures are able to deliver personalized electric stimuli to target tissues. As such, this technology holds potential for a variety of innovative biomedical devices. However, to date, no detailed analyses have been conducted to evaluate the impact of stimulator architecture and geometry on stimuli features. This work characterizes, for the first time, the electric stimuli delivered to bone cellular tissues during in vitro experiments, when using three capacitive architectures: stripped, interdigitated and circular patterns. Computational models are presented that predict the influence of cell confluence, cosurface architecture, electrodes geometry, gap size between electrodes and power excitation on the stimuli delivered to cellular layers. The results demonstrate that these stimulators are able to deliver osteoconductive stimuli. Significant differences in stimuli distributions were observed for different stimulator designs and different external excitations. The thickness specification was found to be of utmost importance. In vitro experiments using an osteoblastic cell line highlight that cosurface stimulation at a low frequency can enhance osteoconductive responses, with some electrode-specific differences being found. A major feature of this type of work is that it enables future detailed analyses of stimuli distribution throughout more complex biological structures, such as tissues and organs, towards sophisticated biodevice personalization.
3D ITO-nanowire networks as transparent electrode for all-terrain substrate
Authors: Li Qiang , Tian Zhenhuan , Zhang Yuantao , Wang Zuming , Li Yufeng , Ding Wen , Wang Tao , Yun Feng 
Published: March 2019

AbstractA 3D ITO nanowire network with high quality by using polystyrene as an assisted material has been prepared, demonstrating superior optoelectronic performances with a sheet resistance of 193 Ω/sq at 96% transmission. Both remarkable flexibility tested under bending stress and excellent adhesion applied on special terrain substrate have been achieved. This method has led to a full coverage of micro-holes at a depth of 18 µm and a bottom spacing of only 1 µm, as well as a perfect gap-free coverage for micro-tubes and pyramid array. It has been proved that this 3D ITO nanowire network can be used as a transparent conductive layer for optoelectronic devices with any topography surface. Through the application on the micro-holes, -tubes and -pyramid array, some new characteristics of the 3D ITO nanowires in solar cells, sensors, micro-lasers and flexible LEDs have been found. Such 3D ITO nanowire networks could be fabricated directly on micro-irregular substrates, which will greatly promote the application of the heterotypic devices.
Investigating the active site of human trimethyllysine hydroxylase
Authors: Wang Yali , Reddy Y. Vijayendar , Al Temimi Abbas H. K. , Venselaar Hanka , Nelissen Frank H. T. , Lenstra Danny C. , Mecinović Jasmin 
Published: March 2019

Abstract
The biologically important carnitine biosynthesis pathway in humans proceeds via four enzymatic steps. The first step in carnitine biosynthesis is catalyzed by trimethyllysine hydroxylase (TMLH), a non-heme Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase, which catalyzes the stereospecific hydroxylation of (2S)-Nε-trimethyllysine to (2S,3S)-3-hydroxy-Nε-trimethyllysine. Here, we report biocatalytic studies on human TMLH and its 19 variants introduced through site-directed mutagenesis. Amino acid substitutions at the sites involved in binding of the Fe(II) cofactor, 2OG cosubstrate and (2S)-Nε-trimethyllysine substrate provide a basic insight into the binding requirements that determine an efficient TMLH-catalyzed conversion of (2S)-Nε-trimethyllysine to (2S,3S)-3-hydroxy-Nε-trimethyllysine. This work demonstrates the importance of the recognition sites that contribute to the enzymatic activity of TMLH: the Fe(II)-binding H242–D244–H389 residues, R391–R398 involved in 2OG binding and several residues (D231, N334 and the aromatic cage comprised of W221, Y217 and Y234) associated with binding of (2S)-Nε-trimethyllysine.
Improved dielectric properties achieved by blending PP and PVDF
Authors: Fan Benhui , He Delong , Liu Yu , Zhou Mingyu , Zhang Chong , Bai Jinbo 
Published: March 2019

Polymer films composed of polypropylene (PP) and poly(vinylidene fluoride) (PVDF) have been fabricated by extrusion with filming system. Owing to the low content of crystallites and the lubricant of carbon black, the commercial product PVDF 370 can be compatible with PP by simply blending at the molten state and the obtained film has improved dielectric constant (ɛ ′ = 4.5) and reduced dielectric loss (tan δ  = 0.5%) at 1000 Hz. The modified dielectric properties result from the high dielectric constant of PVDF and low dielectric loss of PP. In addition, by introducing the third polymer, low‐density polyethylene (LDPE), the dielectric constant of the ternary blends (PP/PVDF 370/LDPE) can further be increased.
Linda Williams’ „Hard Core“
Authors: Döring Nicola 
Published: March 2019

ZusammenfassungDie Monografie „Hard Core“ der US-amerikanischen Filmwissenschaftlerin Linda Williams erschien im Jahr 1989, inmitten der „feministischen Porno-Kriege“. Das Buch gilt als Klassiker der Pornografie-Forschung, da es sich eben nicht um eine weitere ideologische Streitschrift für oder gegen Pornografie handelt, sondern erstmals um eine wissenschaftliche Arbeit, die das Genre des pornografischen Films detailliert in seiner historischen Entwicklung und Machart analysiert. Anlässlich des 30. Geburtstags des Werkes stellt der vorliegende Beitrag die Autorin und ihr Buch vor, geht auf seine Rezeptionsgeschichte ein und arbeitet die Bedeutung für die heute boomende Pornografie-Forschung heraus.
Implementation of endoscopic submucosal dissection for early upper gastrointestinal tract cancer after primary experience in colorectal endoscopic submucosal dissection
Authors: Mocker Lena , Hildenbrand Ralf , Oyama Tsuneo , Sido Bernd , Yahagi Naohisa , Dumoulin Franz 
Published: March 2019

Abstract
Background Current guidelines recommend endoscopic submucosal dissection (ESD) as a treatment option for early cancers of the upper gastrointestinal tract with absent or minimal risk of lymph node metastasis. However, due to the low prevalence of these entities, it is difficult to achieve a competence level for ESD of upper gastrointestinal tract cancers in the Western World. Here, we present single-center data on the implementation of upper gastrointestinal ESD after previous experience with 89 colorectal ESD cases.
Methods Retrospective case series of 39 consecutive patients with early cancers of the esophagus (n = 13) or cardia and stomach (n = 26) treated with ESD over a 4-year period.
Results ESD was technically feasible in all cases with en bloc, R0, and curative resection rates of 100 %, 76.9 %, and 71.8 %, respectively, and a mean procedure time of 100 minutes (30 – 360 minutes). After an initial 20 procedures, the R0 and curative resection rates increased from 65.0 % to 89.5 %, and from 60.0 % to 84.2 %, respectively. Complications were observed in four patients (10.3 %): three perforations, one case of delayed bleeding, and one esophageal stricture. No case required emergency surgery; the 30-day mortality rate was 0 %.
Conclusion In this modest case series from Europe, we observed an effectiveness and complication rate for ESD for early esophageal and gastric cancer that are comparable to other series from Europe but also to more abundant data from Asia. The results indicate that even small numbers of upper gastrointestinal cancers can be managed adequately in centers with expertise in colorectal ESD.
Fulminant Essential Thrombocythemia Associated with Acquired Von Willebrand Syndrome and Bleeding Episodes in a 14-year-old Girl
Authors: Schneider C. , Stutz-Grunder E. , Lüer S. , Keller P. , Kremer Hovinga J. A. , Ammann R. A. , Karow A. 
Published: March 2019

Background Essential thrombocythemia is a chronic myeloproliferative neoplasm. It is extremely rare in children below 15 years of age with an estimated annual incidence of only 0.09 per million. Usually, clinical symptoms associated with essential thrombocythemia are mild or absent.
Case Here, we present the case of a 14-year-old female patient fulminantly presenting with acute symptoms comprising visual impairment, palmar and plantar stabbing pain. Blood count revealed massive thrombocytosis of 2373 × 109/L. Bone marrow morphology showed elevated numbers of mature megakaryocytes. Von Willebrand factor activity/antigen ratio was significantly reduced compatible with an acquired Von Willebrand syndrome associated with high platelet counts. Molecular analyses for driver mutations of myeloproliferative neoplasms including JAK2V617F, CALR and MPL were negative. Acute therapy comprising hyperhydration and oxygen supply complemented by acetylsalicylic acid led to amelioration of symptoms. Medication with hydroxycarbamide maintained a significant reduction of platelet counts but had to be reduced or withheld several times due to neutropenia. Repeated bleeding episodes observed in the course were clearly associated with increases in platelet counts above 1200 × 109/L explained by acquired von Willebrand syndrome. Sixteen months after diagnosis, therapy was switched to pegylated interferon and platelet counts could be stabilized without significant side effects.
Changing of the guard: mixed specialization and flexibility in nest defense (Tetragonisca angustula)
Authors: Baudier Kaitlin M , Ostwald Madeleine M , Grüter Christoph , Segers Francisca H I D , Roubik David W , Pavlic Theodore P , Pratt Stephen C , Fewell Jennifer H 
Published: March 2019

AbstractTask allocation is a central challenge of collective behavior in a variety of group-living species, and this is particularly the case for the allocation of social insect workers for group defense. In social insects, both benefits and considerable costs are associated with the production of specialized soldiers. We asked whether colonies mitigate costs of production of specialized soldiers by simultaneously employing behavioral flexibility in nonspecialist workers that can augment defense capabilities at short time scales. We studied colonies of the stingless bee Tetragonisca angustula, a species that has 2 discrete nest-guarding tasks typically performed by majors: hovering guarding and standing guarding. Majors showed age polyethism across nest-guarding tasks, first hovering and then changing to the task of standing guarding after 1 week. Colonies were also able to reassign minors to guarding tasks when majors were experimentally removed. Replacement guards persisted in nest defense tasks until colonies produced enough majors to return to their initial state. Tetragonisca angustula colonies thus employed a coordinated set of specialization strategies in nest defense: morphologically specialized soldiers, age polyethism among soldiers within specific guarding tasks, and rapid flexible reallocation of nonspecialists to guarding during soldier loss. This mixed strategy achieves the benefits of a highly specialized defensive force while maintaining the potential for rapid reinforcement when soldiers are lost or colonies face unexpectedly intense attack.
Frequent ventricular extrasystoles after heart transplantation: a late presentation of amiodarone-induced thyrotoxicosis: a case report
Authors: Simonenko Maria , Fedotov Petr , Babenko Alina , Karpenko Mikhail 
Published: March 2019

Abstract

Background
There is a lack of information about a mixed type of amiodarone-induced thyrotoxicosis (AIT) after heart transplantation (HTx) with no amiodarone treatment in almost 1 year. Frequent ventricular extrasystoles (VES) associated with a mixed type of AIT can often be treated using thiamazole and prednisolone, without the need for specific antiarrhythmic treatment.

Case summary
We present a clinical case of a 65-year-old heart transplanted male patient with frequent VES associated with mixed type of AIT. Recipient had managed with amiodarone prior to HTx but there were no indications for it after the surgery. One year after antiarrhythmic treatment was discontinued, monomorphic VES (total amount: 27 472/day) were diagnosed. In addition, our investigation revealed that thyrotoxicosis developed. Prednisolone and thiamazole were added to the treatment with positive outcomes. The antithyroid treatment had been discontinued after 9 months and results of the 24-h Holter electrocardiogram monitoring showed only two VES/24 h.

Discussion
The case highlights the association of amiodarone, thyroid disorders, and VES. In mixed type AIT or if diagnosis is uncertain, it is reasonable to use mixed therapy. Next is to decide whether you need special treatment for VES. There was no evidence of ventricular tachycardia. Thyroid function tests remained normal off antithyroid medications and the total amount of VES significantly decreased. There were no indications for any antiarrhythmic treatment or ablation.
Self-efficacy and social competence reduce socioeconomic inequality in emotional symptoms among schoolchildren
Authors: Meilstrup Charlotte , Holstein Bjørn E , Nielsen Line , Due Pernille , Koushede Vibeke 
Published: March 2019

AbstractBackgroundMany adolescents experience mental health problems which may have serious consequences for short- and long-term health and wellbeing. This study investigates socioeconomic inequality in emotional symptoms, self-efficacy and social competence. Further, whether self-efficacy and social competence reduce socioeconomic inequalities in emotional symptoms.MethodsData stem from the cross-sectional Danish Health Behaviour in School-aged Children Methodology Development Survey 2012. Data were collected among all schoolchildren in grades 5–9 (11–15-year-olds) in 23 public schools in two municipalities. Participation rate was 76.8% (n = 3969). Analyses of the associations between daily emotional symptoms, occupational social class, self-efficacy and social competence were performed through logistic regression analyses using SAS version 9.3. Multilevel logistic regression analyses were used to study effect modification.ResultsSchoolchildren from lower socioeconomic positions have higher odds for daily emotional symptoms and lower levels of high self-efficacy and high social competence compared to schoolchildren from higher socioeconomic positions. High self-efficacy and high social competence buffer the association between socioeconomic position and emotional symptoms, i.e. they seem to protect children and adolescents from lower socioeconomic strata against the higher risk of daily emotional symptoms.ConclusionsHigh self-efficacy and high social competence buffer the negative effects of low socioeconomic status on emotional symptoms among schoolchildren. Self-efficacy and social competence can be promoted e.g. through school-based initiatives and may be an effective way to improve mental health and reduce socioeconomic inequality in emotional symptoms among children and adolescents.
Transnational exchange of surveillance data reveals previously unrecognized TBEV microfocus
Authors: Ocias Lukas Frans , Waldeck Mattias , Hallén Ingemar , Nørgaard Mathilde , Krogfelt Karen Angeliki 
Published: March 2019

AbstractTick-borne encephalitis (TBE) is a tick-borne infection with an increasing presence in many European countries. It is caused by the TBE virus (TBEV), a flavivirus transmitted by the Ixodes ricinus tick in northern Europe. In Denmark, the virus exists endemically on the island of Bornholm. However, a large proportion of Danish cases are also imported from Sweden, where the incidence of TBE has steadily been increasing during the last few decades. With the prospect of expanding risk areas due to climate change, TBE surveillance data exchange between countries could facilitate the identification of new TBEV microfoci and thereby aid healthcare workers in the issuing of vaccination recommendations. We present data from a collaborative effort between Denmark and Sweden on the surveillance of TBEV that resulted in the uncovering of a previously unrecognized possible TBEV microfocus in central Sweden.
Epidemiological linkage of vancomycin-resistant Enterococcus faecium from different sources in Ahwaz, Iran
Authors: Arshadi Maniya , Shokoohizadeh Leili , Douraghi Masoumeh , Owlia Parviz , Mashhadi Rahil , Soltani Saber , Pourmand Mohammad Reza 
Published: March 2019

ABSTRACT
This study was set to determine the genetic linkage and the clonal relationship between vancomycin-resistant Enterococcusfaecium (VREfm) isolates in three hospitals of Ahwaz city. In this study, 1050 samples were collected from various rectal swabs, hands of health care workers, environmental surfaces, medical equipment and 146 enterococci isolates from clinical sources of three hospitals from March to September 2015. Antimicrobial resistance patterns in VREfm were detected by disk diffusion method. Genetic linkages of VREfm strains were investigated by pulse field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) methods. Out of 366 enterococcal isolates, 163 Enterococcus faecium isolates were found to be resistant to vancomycin. PFGE and MLST analysis showed the presence of 79 pulsotypes and 11 sequence types (ST), respectively. In total, 90% of the isolates belonged to clonal complex 17 (CC17). Three new STs were reported for the first time in this study and ST80 was the predominant ST. We found a high prevalence of diverse VREfm with threatening antibiotic resistance patterns in all the studied sources with the dominance of CC17 VREfm strains in Ahwaz hospitals. Also, the results of typing method showed inter- and intra-hospital circulation of VREfm and similar pulsotypes and STs among different sources.
Tomas–Stein Restriction Estimates on Convex Cocompact Hyperbolic Manifolds
Authors: Han Xiaolong 
Published: March 2019

Abstract
In this paper, we investigate the Tomas–Stein restriction estimates on convex cocompact hyperbolic manifolds $\Gamma \backslash{\mathbb{H}}^{n+1}$. Via the spectral measure of the Laplacian, we prove that the Tomas–Stein restriction estimate holds when the limit set has Hausdorff dimension $\delta _\Gamma &lt;n/2$. This provides an example for which restriction estimate holds in the presence of hyperbolic geodesic trapping.
Gio Ponti’s Latin [American] Encounters: A Reading from the Archives
Authors: Paiva Ponzio Angelica 
Published: March 2019

Abstract
The design languages and forms of knowledge used by architects and other designers indicate that they not only operate ‘within the same domains of knowledge and action’, but also share similar historical contexts. Latin American modern architecture and design histories constitute an account of cultural exchanges between architectural and design practitioners working on a trans-national and multidisciplinary basis. Reviewing these practices today may help break the tendency of historical accounts to focus on a ‘diffusionist model’ and reinforce the critical acknowledgement of the modern legacy in Latin America. The work of architect and designer Gio Ponti is an example of this. During the 1950s Ponti travelled to many countries and built one of his masterpieces, Villa Planchart, in Caracas. Although much has been published about Ponti’s Venezuelan project, his letters reveal other lesser known but significant encounters with Latin American culture. Using his Domus editorials and readings from his correspondence as guidelines, complemented by articles, seminal books, and projects, this article will explore, from a more plural point of view, how Ponti’s experiences and relationships developed in Latin America, especially those lesser known relationships in Brazil, helped shape some of his design processes and conceptualizations.
Two Instances of Language Contact in Isaiah 45:14
Authors: Boyd Samuel 
Published: March 2019

Abstract
Scholars have identified two traces of loans originating from Aramaic and Akkadian in Isa. 45:14. In this article, I examine each of the proposed borrowings, offering further support for the first, but arguing for a different path from Aramaic into the Hebrew of Isa. 45:14 for the second. In doing so, I add precision to the loan phonology of the lexeme as it relates to the sibilants involved and I call into question comparative evidence cited in Ludwig K.hler and Walter Baumgartner's The Hebrew and Aramaic Lexicon of the Old Testament.
‘The Lord’: An Apology for the Muslim Faith from the Island of Soqotra1
Authors: Ad-Da'rhi Issa Gum'an , Kogan Leonid , Cherkashin Dmitry 
Published: March 2019

Abstract
The present study is a unique witness of the nascent literacy in the Modern South Arabian language Soqotri (Island Soqotra, Gulf of Aden, Yemen). For the first time, a consciously created, non-traditional specimen of Soqotri narrative appears both in the newly designed Arabic-based Soqotri script and the standard Semitological transcription, along with an English translation and philological annotations. The motivation behind the creation of this piece is, strikingly, neither artistic nor scientific, but religious, which opens new avenues for the development of the Soqotri language in complex framework of todays Arab and Islamic world: contrary to the widespread belief, Soqotri is not necessarily bound to the transmission of the traditional oral lore, but can serve as an efficient vehicle for creating and publishing texts pertaining to the vital interests of todays islanders.