bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Bioactive Phenolic Compounds Extracted from Hydro-Distillation By-Products of Spanish Lamiaceae Plants
Authors: Pérez-Magariño Silvia , Bueno-Herrera Marta , Asensio-S.-Manzanera M. Carmen 
Published: November 2024

Plants of the Lamiaceae family are widely used for the extraction of essential oils, and this industry generates a large number of solid residues as by-products, which contain non-volatile valuable compounds. The aim of this work was to identify and quantify the phenolic compounds present in these solid residues from different important Spanish species of Lamiaceae to characterize and valorize them. Forty-seven phenolic compounds were identified by HPLC-DAD-MS and quantified by HPLC-DAD. Different concentrations and types of phenolic compounds were found between the solid residues. The Rosmarinus officinalis extracts showed the highest total phenolic content due to their high phenolic terpene concentrations. The Thymus mastichina extracts were characterized by kaempferol and flavanones, and some flavones were derived from luteolin and apigenin. Finally, the sample Lavandula and Salvia lavandulifolia extracts presented the lowest content of most phenolic compounds, with the exception of some phenolic acids, such as danshensu, salvianolic acid A, and glucosides of hydroxycinnamic acids. Therefore, this work provides information on the quantification of a large number of phenolic compounds using a simple, sensitive, reproducible, and accurate methodology. In addition, the results indicate that these solid residues still contain important amounts of different polyphenols, which are antioxidants and can be used in different industries.
Macrophage-Specific Lactate Dehydrogenase Expression Modulates Inflammatory Function In Vitro
Authors: Lu Yan , Osis Gunars , Zmijewska Anna A. , Traylor Amie , Thukral Saakshi , Wilson Landon , Barnes Stephen , George James F. , Agarwal Anupam 
Published: November 2024

Key Points

Lactate dehydrogenase A deletion alters macrophage function.Lactate dehydrogenase A could serve as a potential therapeutic target in AKI.

Background
In AKI, macrophages play a major role in regulating inflammation. Classically activated macrophages (M1) undergo drastic metabolic reprogramming during their differentiation and upregulate the aerobic glycolysis pathway to fulfill their proinflammatory functions. NAD+ regeneration is crucial for the maintenance of glycolysis, and the most direct pathway by which this occurs is through the fermentation of pyruvate to lactate, catalyzed by lactate dehydrogenase A (LDHA). Our previous study determined that LDHA is predominantly expressed in the proximal segments of the nephron in the mouse kidney and increases with hypoxia. This study investigates the potential of LDHA as a therapeutic target for inflammation by exploring its role in macrophage function in vitro.

Methods
Bone marrow–derived macrophages (BMDMs) were isolated from myeloid-specific LDHA knockout mice derived from crossbreeding LysM-Cre transgenic mice and LDHA floxed mice. RNA sequencing and LC-MS/MS metabolomics analyses were used in this study to determine the effect of LDHA deletion on BMDMs after stimulation with IFN-γ.

Results
LDHA deletion in IFN-γ BMDMs resulted in a significant alteration of the macrophage activation and functional pathways and change in glycolytic, cytokine, and chemokine gene expression. Metabolite concentrations associated with proinflammatory macrophage profiles were diminished, whereas anti-inflammatory–associated ones were increased in LDHA knockout BMDMs. Glutamate and amino sugar metabolic pathways were significantly affected by the LDHA deletion. A combined multiomics analysis highlighted changes in Rap1 signaling, cytokine–cytokine receptor interaction, focal adhesion, and mitogen-activated protein kinase signaling metabolism pathways.

Conclusions
Deletion of LDHA in macrophages results in a notable reduction in the proinflammatory profile and concurrent upregulation of anti-inflammatory pathways. These findings suggest that LDHA could serve as a promising therapeutic target for inflammation, a key contributor to the pathogenesis of AKI.
Home Dialysis for Latinx Individuals Living with Kidney Failure
Authors: Rizzolo Katherine , Jauregui Rebeca Gonzalez , Teakell Jade , Chonchol Michel , Waikar Sushrut S. , Cervantes Lilia 
Published: November 2024

Key Points

Individual-level advocacy to overcome structural barriers to home dialysis is key in improving home dialysis access for Latinx individuals.Acknowledging patient influences on dialysis modality choice is critical for Latinx individuals with kidney failure.Early, repeated education from a trusted source is important for Latinx individuals with kidney failure.

Background
Latinx individuals experience two times the incidence of kidney failure compared with non-Latinx individuals and are less likely to use home dialysis therapies. In this qualitative study, interdisciplinary home dialysis clinicians were interviewed to understand the key factors and strategies used by clinicians to improve home dialysis uptake among the Latinx community.

Methods
One-to-one, semistructured interviews were conducted between November 2021 and March 2023 with 25 home dialysis interdisciplinary clinicians in Denver, Colorado, and Houston, Texas. Interviews were audio-recorded, transcribed, and analyzed using thematic analysis.

Results
We identified three themes that focus on different levels of clinician advocacy in home dialysis uptake for the Latinx community: (1) individual patient-level advocacy (helping patients overcome social challenges to home dialysis, cultivating personalized relationships, educating patients with in-person versus phone language interpretation, understanding cultural differences in communication), (2) understanding patient influences on modality decision-making (acknowledging the importance of cultural concordance with clinician educator and patient peers, incorporating the patient lived experience, connecting with a patient's social support network, highlighting greater flexibility for employment, underscoring flexibility with culturally concordant foods), and (3) changes to education at the dialysis facility level (standardizing routine and repeated modality education, promoting early and patient-centered education).

Conclusions
Clinicians outlined efforts to improve access to home dialysis for Latinx groups on the patient and system level; in particular, individual-level and system-level advocacy was grounded in trusting relationships and personalized education. A future intervention that improves the quality and personalization of dialysis modality education incorporating Latinx cultural values may improve access to home dialysis for Latinx people with kidney disease.
United Airlines In-Flight Wi-Fi Health Management: Revolutionizing Aircraft Connectivity through Real-time Prognostics and Big Data Analysis
Authors: Rahimi Ehsan , Ling Shuang , Mesen Luis 
Published: November 2024

This paper highlights an innovative initiative, focusing on Prognostics and Health Management (PHM) to enhance in-flight Wi-Fi performance by proactively identifying aircraft component failures. We propose a novel metric, the Normalized Wi-Fi Health Score (NWiHS), alongside a corresponding alerting mechanism, which together represents a significant advancement in the evaluation and improvement of in-flight Wi-Fi connectivity. To achieve this goal, we utilized big data consisting of millions of historical Wi-Fi heartbeats (HBs) received from each aircraft over the past three years. These HBs refer to periodic data packet transmissions sent from United’s aircraft to ground stations, providing crucial real-time insights into the Wi-Fi system’s status. Leveraging that data, we utilized advanced statistical methods to estimate a NWiHS - a robust indicator of aircraft-level connectivity performance, which quantifies the percent of missing Wi-Fi HBs normalized to exclude the effect of Wi-Fi provider performance and global coverage.
EIXO CÉREBRO-INTESTINO-PELE E SUAS IMPLICAÇÕES NO DESENVOLVIMENTO DE LESÕES ACNEICAS: UMA REVISÃO SISTEMÁTICA
Authors: Da Silva Cursino Ribeiro Maria Eduarda , Dos Santos Moreira Gabrielle , Silveira Abril Victória , Cardoso Lima Rodrigues Letícia Maria , Evangelista Viana Lucena Ingridy 
Published: November 2024

A acne, cientificamente conhecida como acne vulgar, é uma condição inflamatória crônica da unidade pilossebácea, extremamente comum, com um acometimento global estimado em aproximadamente 80% da população em alguma fase da vida, é sumariamente uma afecção simples, mas que interfere diretamente na qualidade de vida e autoestima dos pacientes que a possuem. Sua fisiopatologia é ainda pouco explorada na prática clínica, e com isso, seu tratamento tem se limitado às abordagens tradicionais que por vezes se mostram insuficientes para a resolução das lesões. Considerando isso, esse estudo objetiva elucidar o funcionamento do eixo cérebro-intestino-pele na formação da acne, compreendendo de que forma essas lesões de pele são causa ou consequência de desbalanços no sistema gastrointestinal - como a disbiose - e no sistema nervoso - sobretudo no que se refere às doenças e sintomas psíquicos como estresse, ansiedade e depressão. Para isso, foi realizada uma revisão sistemática da literatura, sendo utilizadas as bases de dados LILACS, SciELO e PUBMED. Sendo incluídos trabalhos em inglês, espanhol e português de 2019 a 2024, foram selecionados 33 artigos para análise precisa.
Por meio disso, observou-se a estreita relação entre o eixo que liga o sistema nervoso, gastrointestinal e a pele no desenvolvimento das lesões acneicas. O estresse foi fortemente relacionado ao desencadeamento da acne através da ativação do eixo Hipotálamo-Hipófise-Adrenal, ao passo que as lesões de pele, afetando a autoestima somado aos estigmas sociais é também evento desencadeador de estresse e ansiedade. A microbiota intestinal por sua vez, demonstrou estar intimamente ligada à acne tanto por meio da disbiose quanto pelas interferências dietéticas no metabolismo humano. Assim, foi possível concluir que o eixo cérebro-intestino-pele não apenas está ligado à fisiopatologia da acne como muito pode contribuir para tornar seu tratamento mais efetivo, fazendo uso de terapias complementares visando melhorar o aspecto das lesões bem como o funcionamento intestinal e a saúde psíquica dos pacientes.
Hubungan Antara Tingkat Pengetahuan Perawat Tentang Kejadian Infeksi Nosokomial dengan Upaya Pencegahan di Lingkungan IGD Rumah Sakit Bhayangkara Brimob Depok
Authors: Iriana Sumirati Asep Rusman , Khamid Abdul 
Published: November 2024

Menurut data (WHO) pada tahun 2016 bahwa di Eropa prevelensi kejadian infeksi nosokomial setiap tahunnya lebih dari 4-4,5 juta pasien, sedangkan di Amerika Serikat prevelensi diperkirakan 1,7 juta pasien. Prevelensi ini mewakili 4,5 % untuk 99.000 kematian akibat infeksi nosokomial. Tercatat 7 kasus dari 100 penderita masuk rumah sakit di Negara berkembang dan 10 kasus dari 100 orang di Negara sedang berkembang yang terkena infeksi nosokomial. Tujuan Penelitian: Untuk mengetahui hubungan antara tingkat pengetahuan perawat tentang kejadian infeksi nosokomial dengan upaya pencegahannya di lingkungan IGD Rumah Sakit Bhayangkara Brimob Kelapadua Depok. Metode Penelitian: Penelitian ini adalah penelitian kuantitatif dengan pendekatan cross sectional study yaitu suatu penelitian untuk mempelajari dinamika korelasi antara faktor resiko dengan efek melalui pendekatan, dengan cara pendekatan, observasi dan pengumpulan data sekaligus pada suatu saat (point time approach).
Hasil Penelitian: Menunjukkan tingkat pengetahuan berhubungan dengan upaya pencegahan infeksi nosokiomial (p-value 0,003). Kesimpulan dan Saran: Ada hubungan antara tingkat pengetahuan dengan pencegahan infeksi nosokiomial. Diharapkan pihak Rumah Sakit dapat memberikan pelatihan serta seminar bagi perawat terkait kemampuan dalam pencegahan dan pengendalian infeksi nosokomial, sehingga kenaikan angka kejadian infeksi nosokomial dapat dihindari.
Efektivitas Pemberian Pijat Akupresure Titik P6 (Nei Guan) Disertai Pemberian Sari Jahe dan Madu Tehadap Emesis Gravidarum pada Ibu Hamil
Authors: Khairiah Rahayu , Masluroh  
Published: November 2024

Emesis gravidarum dapat menimbulkan komplikasi pada ibu dan janinnya karena terjadi kekurangan nutrisi dan cairan sehingga keadaan fisik ibu menjadi lemah dan lelah. Penyebab utamanya karena tingginya fluktuasi kadar hCG. Salah satu cara non farmakologi yang dapat mengurangi emesis gravidarum adalah dengan pijat akupresure titik p6 (nei guan) disertai pemberian sari jahe dan madu. Tujuan: untuk mengetahui efektifitas pemberian pijat akupresure titik p6 (nei guan) disertai pemberian sari jahe dan madu terhadap emesis gravidarum pada ibu hamil trimester I di PMB H Grogol Petamburan Kota Jakarta Barat Tahun 2020. Metode penelitian: pre-eksperimental desain dengan rancangan one group pretest-posttest design. Sampel penelitian adalah ibu hamil trimester I mengalami emesis gravidarum sebanyak 36 responden dengan teknik purposive sampling. Instrumen penelitian menggunakan lembar observasi kuesioner PUQE-24. Data merupakan data primer dianalisis menggunakan uji paired sample t-test. Hasil: analisis univariat emesis gravidarum pada ibu hamil trimester I sebelum pemberian pijat akupresure titik P6 (Nei Guan) disertai pemberian sari jahe dan madu dengan rata-rata 9,36 (emesis gravidarum sedang), sesudahnya dengan rata-rata 5,06 (emesis gravidarum ringan). Hasil analisis bivariat terdapat efektifitas pemberian pijat akupresure titik P6 (Nei Guan) disertai pemberian sari jahe dan madu terhadap emesis gravidarum pada ibu hamil trimester I dengan nilai p value = 0,000. Kesimpulan dan Saran terdapat efektifitas pemberian pijat akupresure titik P6 (Nei Guan) disertai pemberian sari jahe dan madu terhadap emesis gravidarum pada ibu hamil trimester I. Ibu hamil diharapkan dapat menerapkan terapi pijat akupresure titik p6 (nei guan) disertai pemberian sari jahe dan madu pada saat menghadapi emisis gravidarum.
The ESO SupJup Survey. III. Confirmation of 13CO in YSES 1 b and Atmospheric Detection of YSES 1 c with CRIRES+
Authors: Zhang Yapeng , González Picos Darío , de Regt Sam , Snellen Ignas A. G. , Gandhi Siddharth , Ginski Christian , Kesseli Aurora Y. , Landman Rico , Mollière Paul , Nasedkin Evert , Sánchez-López Alejandro , Stolker Tomas , Inglis Julie , Knutson Heather A. , Mawet Dimitri , Wallack Nicole , Xuan Jerry W. 
Published: November 2024

Abstract
High-resolution spectroscopic characterization of young super-Jovian planets enables precise constraints on elemental and isotopic abundances of their atmospheres. As part of the ESO SupJup Survey, we present high-resolution spectral observations of two wide-orbit super-Jupiters in YSES 1 (or TYC 8998-760-1) using the upgraded VLT/CRIRES+ (

R

∼

100,000

) in K-band. We carry out free atmospheric retrieval analyses to constrain chemical and isotopic abundances, temperature structures, rotation velocities (

v
sin
i

), and radial velocities. We confirm the previous detection of 13CO in YSES 1 b at a higher significance of 12.6σ, but point to a higher 12CO/13CO ratio of 88 ± 13 (1σ confidence interval), consistent with the primary’s isotope ratio 66 ± 5. We retrieve a solar-like composition in YSES 1 b with a C/O = 0.57 ± 0.01, indicating a formation via gravitational instability or core accretion beyond the CO iceline. Additionally, the observations lead to detections of H2O and CO in the outer planet YSES 1 c at 7.3σ and 5.7σ, respectively. We constrain the atmospheric C/O ratio of YSES 1 c to be either solar or subsolar (C/O = 0.36 ± 0.15), indicating the accretion of oxygen-rich solids. The two companions have distinct

v
sin
i

, 5.34 ± 0.14 km s−1 for YSES 1 b and 11.3 ± 2.1 km s−1 for YSES 1 c, despite their similar natal environments. This may indicate different spin axis inclinations or effective magnetic braking by the long-lived circumplanetary disk around YSES 1 b. YSES 1 represents an intriguing system for comparative studies of super-Jovian companions and linking present atmospheres to formation histories.
Double-peaked Narrow Emission-line Galaxies in SDSS-IV MaNGA
Authors: Qiu Jiajie , Shen Shiyin , Feng Shuai , Chen Yanmei , Chang Ruixiang , Zhao Qianwen , Zeng Qi 
Published: November 2024

Abstract
Narrow emission lines in a galaxy’s spectrum that show double peaks indicate the presence of distinct gas components with different velocities, and its physical origin remains uncertain. This study uses galaxies from the final MaNGA data release to detect double-peaked narrow emission-line spaxels (DPSs) by examining the double Gaussian profiles of the Hα-[N ii] doublets across all MaNGA spaxels. A total of 5420 DPSs associated with 304 double-peaked narrow emission-line galaxies (DPGs) are identified, with each DPG containing a minimum of five DPSs and being free from overlap with other galaxies. We find that DPSs can be categorized into three groups according to their central distance r/R

e
and the velocity difference Δv between their two components: the inner low-Δv, inner high-Δv, and outer DPSs. By incorporating the physical characteristics of the DPGs into their DPSs, we demonstrate for the first time the existence of statistical correlations between barred DPGs and inner low-Δv DPSs, AGN-hosting DPGs, and inner high-Δv DPSs, as well as tidal DPGs and outer DPSs.
How the Galaxy–Halo Connection Depends on Large-scale Environment
Authors: Wu John F. , Jespersen Christian Kragh , Wechsler Risa H. 
Published: November 2024

Abstract
We investigate the connection between galaxies, dark matter halos, and their large-scale environments at z = 0 with Illustris TNG300 hydrodynamic simulation data. We predict stellar masses from subhalo properties to test two types of machine learning (ML) models: explainable boosting machines (EBMs) with simple galaxy environment features and

E
(
3
)

-invariant graph neural networks (GNNs). The best-performing EBM models leverage spherically averaged overdensity features on 3 Mpc scales. Interpretations via SHapley Additive exPlanations also suggest that in the context of the TNG300 galaxy–halo connection, simple spherical overdensity on ∼3 Mpc scales is more important than cosmic web distance features measured using the DisPerSE algorithm. Meanwhile, a GNN with connectivity defined by a fixed linking length, L, outperforms the EBM models by a significant margin. As we increase the linking length scale, GNNs learn important environmental contributions up to the largest scales we probe (L = 10 Mpc). We conclude that 3 Mpc distance scales are most critical for describing the TNG galaxy–halo connection using the spherical overdensity parameterization, but that information on larger scales, which is not captured by simple environmental parameters or cosmic web features, can further augment these models. Our study highlights the benefits of using interpretable ML algorithms to explain models of astrophysical phenomena, and the power of using GNNs to flexibly learn complex relationships directly from data while imposing constraints from physical symmetries.
Reconstruction of the Total Solar Irradiance During the Last Millennium
Authors: Penza Valentina , Bertello Luca , Cantoresi Matteo , Criscuoli Serena , Lucaferri Lorenza , Reda Raffaele , Ulzega Simone , Berrilli Francesco 
Published: November 2024

Abstract
Solar irradiance variations across various timescales, from minutes to centuries, represent a potential natural driver of past regional and global climate cold phases. To accurately assess the Sun’s effect on climate, particularly during periods of exceptionally low solar activity, known as grand minima, an accurate reconstruction of solar forcing is essential. While direct measurements of the total solar irradiance (TSI) only began in the late 1970s, with the advent of space radiometers, indirect evidence from various historical proxies suggests that the Sun’s magnetic activity has undergone possible significant fluctuations over much longer timescales. Employing diverse and independent methods for TSI reconstruction is essential to gaining a comprehensive understanding of this issue. This study employs a semi-empirical model to reconstruct TSI over the past millennium. Our approach uses an estimated open solar magnetic field (F

o
), derived from cosmogenic isotope data, as a proxy for solar activity. We reconstruct the cyclic variations of TSI, due to the solar surface magnetic features, by correlating F

o
with the parameter of active region functional form. We obtain the long-term TSI trend by applying the empirical mode decomposition algorithm to the reconstructed F

o
to filter out the 11 yr and 22 yr solar variability. We prepare a reconstructed TSI record, spanning 971 to 2020 CE. The estimated departure from modern TSI values occurred during the Spörer minimum (around 1400 CE), with a decrease of approximately 2.3 Wm−2. A slightly smaller decline of 2.2 Wm−2 is reported during the Maunder minimum, between 1645 and 1715 CE.
Subrelativistic Outflow and Hours-timescale Large-amplitude X-Ray Dips during Super-Eddington Accretion onto a Low-mass Massive Black Hole in the Tidal Disruption Event AT2022lri
Authors: Yao Yuhan , Guolo Muryel , Tombesi Francesco , Li Ruancun , Gezari Suvi , García Javier A. , Dai Lixin , Chornock Ryan , Lu Wenbin , Kulkarni S. R. , Gendreau Keith C. , Pasham Dheeraj R. , Cenko S. Bradley , Kara Erin , Margutti Raffaella , Ajay Yukta , Wevers Thomas , Kwan Tom M. , Andreoni Igor , Bloom Joshua S. , Drake Andrew J. , Graham Matthew J. , Hammerstein Erica , Laher Russ R. , LeBaron Natalie , Mahabal Ashish A. , O’Connor Brendan , Purdum Josiah , Ravi Vikram , Sears Huei , Sharma Yashvi , Smith Roger , Sollerman Jesper , Somalwar Jean J. , Wold Avery 
Published: November 2024

Abstract
We present the tidal disruption event (TDE) AT2022lri, hosted in a nearby (≈144 Mpc) quiescent galaxy with a low-mass massive black hole (104
M
⊙ < M
BH < 106
M
⊙). AT2022lri belongs to the TDE-H+He subtype. More than 1 Ms of X-ray data were collected with NICER, Swift, and XMM-Newton from 187 to 672 days after peak. The X-ray luminosity gradually declined from 1.5 × 1044 erg s−1 to 1.5 × 1043 erg s−1 and remains much above the UV and optical luminosity, consistent with a super-Eddington accretion flow viewed face-on. Sporadic strong X-ray dips atop a long-term decline are observed, with a variability timescale of ≈0.5 hr–1 days and amplitude of ≈2–8. When fitted with simple continuum models, the X-ray spectrum is dominated by a thermal disk component with inner temperature going from ∼146 to ∼86 eV. However, there are residual features that peak around 1 keV, which, in some cases, cannot be reproduced by a single broad emission line. We analyzed a subset of time-resolved spectra with two physically motivated models describing a scenario either where ionized absorbers contribute extra absorption and emission lines or where disk reflection plays an important role. Both models provide good and statistically comparable fits, show that the X-ray dips are correlated with drops in the inner disk temperature, and require the existence of subrelativistic (0.1–0.3c) ionized outflows. We propose that the disk temperature fluctuation stems from episodic drops of the mass accretion rate triggered by magnetic instabilities or/and wobbling of the inner accretion disk along the black hole’s spin axis.