bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospitalization of Pediatric Patients with Oral and Pharyngeal Cancer in Brazil’s National Health System from 2008 to 2023
Authors: Lima Ricardo Barbosa , Bispo Stefany Santana , Fontes Nathan Henrique de Santana , Santos Everton Guilherme Jesus dos , Sobral Talita Silva , Sarmento Aquiles Sales Craveiro , Gomes Breno Gustavo do Nascimento , Garcia Silas Zambaldi 
Published: November 2024

Introduction: Pediatric cancer patients often need inpatient admissions due to treatment or complications, but this variable was notsystematically evaluated in Brazil’s public health services. Objective: To evaluate inpatient admissions of children and adolescents withoral and pharyngeal cancer in the Brazilian public healthcare system. Method: Population-based approach study from 2008 to 2023 of the annual hospitalizations recovered and normalized per 1,000,000 inhabitants aged 0-19 years (person-year incidence), in addition to the annual deaths, hospital mortality (%), length of hospital stay (days), costs (R$), and conditions (elective or urgent). The significance level was adjusted to 5%, according to Prais-Winsten generalized linear regression models. Results: From 2008 to 2023, 24,662 inpatient admissions were approved, 50.5% of which classified as urgent. The incidence was 395 per 1,000,000 0-19 aged children. During this period, 626 deaths were reported, representing 2.5% of all hospitalizations. Moreover, the mean length of stay was 5.8 days and the mean cost was R$ 1,526.87. There was a decreasing time trend in the incidence of hospitalizations of children and adolescents (both p < 0.001). The incidence and hospital mortality were significantly lower among children and adolescents compared to other age groups (all p < 0.001). Conclusion: Over the last 16 years, an important number of inpatient admissions of children and adolescents with oral and pharyngeal cancer in the Brazilian public healthcare system was recorded, revealing specific patterns of hospital morbidity.
#OpenAccess: Free online, open-access crowdsource-reviewed publishing is the future; traditional peer-reviewed journals are on the way out
Authors: Jr. John R. Adler , Chan Teresa M. , Blain J. Bruce , Thoma Brent , Atkinson Paul 
Published: November 2024

<p>This series of editorials will provide CJEM readers with an opportunity to hear differing perspectives on topics pertinent to the practice of emergency medicine. The debaters have been allocated opposing arguments on topics on which there is some controversy or perhaps scientific equipoise.</p>
<p>We continue with the topic of open-access (OA) publishing. With the switch from paper-based publishing to online journals, in the age of free OA medical education (FOAM), and with most publications being fully or partially funded by public money, whether directly or indirectly through academic salaries, is it time to bring down the paywall and allow free OA to medical publications? Alternatively, is there still a role for the traditional paper-based or limited access online journal, with regular readers, traditional peer-review processes, supported by a combination of subscriptions, advertising, and pay-per-view access? Can we open-up access and still maintain high academic standards? John Adler, the Dorothy and TK Chan Professor, Emeritus at Stanford University, and Editor-in-Chief of Cureus.- com, argues that the future of medical publishing should be open and free, with the team led by Teresa Chan, themselves an academic group highly engaged with FOAM, responding that there remains value in a more traditional approach. </p>
Educator's blueprint: A primer on consensus methods in medical education research
Authors: Gottlieb Michael , Caretta-Weyer Holly , Chan Teresa M. , Humphrey-Murto Susan 
Published: November 2024

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<p>Consensus methods such as the Delphi and nominal group techniques are increasingly utilized within medical education research. This educator's blueprint paper provides practical strategies regarding five key steps for ensuring best practices when using consensus methods. These strategies include deciding which consensus method is best, developing the initial questionnaire, identifying the participants, determining the number of rounds and consensus threshold, and describing and justifying any modifications. These strategies will help guide education researchers on their next study using consensus methods.</p>
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Analisis Hubungan Konsep Neo-Klasik Terhadap Hunian Rumah Tinggal Sosialita di Kawasan Pondok Indah
Authors: Yusuff Adisti Ananda , Rochyat Indra Gunara , Wiyono Erina 
Published: November 2024

Masyarakat perkotaan semakin mampu menciptakan rumah layak huni. Rumah harus didesain senyaman mungkin, selain harus berkualitas baik, juga harus mencerminkan status sosial pemiliknya. Rumah mewah bergaya klasik yang sering terlihat di perkotaan memiliki desain yang sangat khas dengan tiang-tiang tinggi di dalamnya, dan awalnya diadopsi dari arsitektur kuno pada zaman Romawi, kemudian diadaptasi ke bangunan tempat tinggal. Di masa ketika segala sesuatunya mewah dan semuanya minimalis dan sederhana, gaya neoklasik ini sangat berbenturan dengan gambaran modern tersebut. Banyak kelompok masyarakat yang ingin membuktikan status sosial mereka dengan mengadopsi gaya modern yang tidak sekompleks neoklasik. Namun memiliki kesan mewah dan memberikan kesan yang sangat mewah. Inilah pertanyaan desain mengapa satu tema tetap mengadopsi kompleksitas, sementara ada tren lain yang lebih sederhana, namun tetap terlihat mewah dan berkelas, serta tidak menurunkan status sosialnya. Fenomena penekanan status sosial yang diterapkan pada bangunan dan interior saat ini sangat beragam. Sangat menarik untuk mengangkat kaitannya dengan fenomena gaya hidup sosial masyarakat kelas atas yang sangat banyak tercermin pada objek-objek yang ada dan menjadi topik yang bisa dibicarakan lebih lanjut dengan menyerahkan seluruh tanggung jawab pada desain yang ada. Metode yang digunakan dalam penelitian ini adalah kuantitatif deskriptif, untuk melakukan penelitian ini perlu dilakukan beberapa tahap pendekatan penelitian. Kehadiran bangunan neoklasik yang banyak mengadopsi arsitektur Romawi dan Yunani sebenarnya merupakan cerminan status sosial masyarakat kelas atas yang selalu ingin terlihat berarsitektur bagus. Hal ini sesuai dengan hakikat kehidupan bermasyarakat. Bangunan dengan massa bangunan yang besar dan tiang-tiang hiasan yang megah ini sangat unik dan menarik serta akan menarik minat banyak orang. Di era modernisasi sekalipun, gaya neoklasik yang bertahan lama tetap memiliki nilai tambah tersendiri, terutama pada gaya hidup kelas atas, di mana bangunan neoklasik mencerminkan status sosialnya yang tinggi, dapat benar-benar ditampilkan.
Activity of Flavonoid Derived Compounds from Medinilla speciosa Extract as Anti-hyperpigmentation against Tyrosinease Proteins with In Silico Methods
Authors: Riantica Elshinta , Nurhayati Awik Puji Dyah , Sa’adah Noor Nailis 
Published: November 2024

Parijoto (Medinilla speciosa), a typical plant from Indonesia, contains flavonoid compounds as antioxidants. It is able to depigment skin by inhibiting tyrosinase activity during melanogenesis, or melanin formation. Melanogenesis occurs through UV light exposure; it stimulates ROS production and triggers the formation of free radicals and melanogenesis. If not prevented, it will have negative impacts on health. Currently, there is no further research regarding the existence of flavonoid compound derivatives found in parijoto fruit. The aim of this research is to initially identify potential flavonoid derivative compounds as tyrosinase inhibitors using in silico methods. The results can be used as an initial reference for making products based on natural ingredients with minimal side effects. This research uses a bioinformatics approach with the molecular docking method of ligands towards proteins. The stages in this research include: downloading and preparing receptors and ligands; docking with Autodock Vina; visualization of results with Biovia Discovery Studio; data analysis; and discussion. The analysis is carried out by looking at the affinity energy values and complex conformation between the receptor-ligand. The results show flavonoid derivative compounds have the potential to act as tyrosinase inhibitors, as proven by compounds interactions with the active site of tyrosinase to produce the amino acid residues phenylalanine, proline, asparagine, arginine, and histamine. Produce respective affinity energy values, namely -8.9; -7.7; -7.6; -7.5; -7.5; and 7.4 kcal/mol for chalcone, catechin, flavonol, flavanol, flavone, and flavonone compounds. Meanwhile, the comparison compound used is kojic acid, with an affinity energy of -5.5 kcal/mol.
IMPLEMENTASI PENGGUNAAN ARTIFICIAL INTELLIGENCE DALAM PEMBUATAN COLLECTIBLE CARD GAME BERLISENSI NONKOMERSIAL
Authors: Kuntoro Hadiyan Yusuf 
Published: November 2024

Di era revolusi industri 4.0, banyak teknologi bersifat disruptif yang mengubah pola-pola kerja yang telah ada. Salah satu teknologi disruptif tersebut adalah artificial intelligence (AI). Ketika artikel ini ditulis, AI dapat digunakan untuk menghadirkan karya-karya seni digital 2D dengan hanya memanfaatkan arahan teks deskripsi, yang disebut dengan text-to-image AI generator. Dalam penelitian ini, text-to-image AI generator dipergunakan untuk membuat ilustrasi-ilustrasi karakter kartu bagi collectible card game (CCG) berlisensi nonkomersial yang tengah dikembangkan penulis, dengan nama Battle for the Power Plants (B.F.T.P.P.). Kartu-kartu dalam CCG yang tengah dikembangkan tersebut dipilih sebagai produk untuk mengimplementasikan ilustrasi-ilustrasi yang dihasilkan oleh AI karena tujuan dari penelitian ini adalah untuk menunjukkan kemampuan AI dalam menghadirkan ilustrasi karakter kartu, menggantikan peran ilustrator manusia. Hasil studi menunjukkan bahwa AI memiliki potensi kemampuan untuk mendisrupsi pangsa pasar pekerjaan bagi ilustrator-ilustrator manusia dikarenakan kecepatan AI dalam menghasilkan ilustrasi dengan kualitas estetika yang hampir sepadan dengan ilustrasi-ilustrasi buatan ilustrator manusia. Kelebihan serta kekurangan baik dalam menggunakan AI maupun ilustrator manusia juga dipaparkan dalam artikel ini.
ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin−mediated degradation and facilitate viral replication
Authors: Ren Yingying , Liu Yishuo , Pang Rui , Xu Gang , Lei Yining , Kwok Hang Fai , Wu Yingliang , Cao Zhijian 
Published: November 2024

IntroductionViral infection usually stimulates a variety of host cell factors to modulate the life cycle of the virus. PIM1, a serine/threonine protein kinase widely involved in cell proliferation, survival, differentiation and apoptosis, was recently reported to be upregulated by Zika virus (ZIKV) infection. However, how ZIKV-PIM1 interactions affect the viral life cycle are not fully understood.Methods and resultsHere, we demonstrated that ZIKV replication was suppressed by the PIM1 kinase inhibitor SGI-1776 in both wt and Ifnar1-/- murine peritoneal macrophages, indicating that PIM1 functions independently of type I IFN signaling. Co-immunoprecipitation and GST pull-down assays revealed that the ZIKV structural protein precursor membrane (prM) interacted with PIM1. Moreover, we found that prM protein stability was enhanced by PIM1, which was attributed to its kinase activity. Mechanistically, we revealed that prM can undergo ubiquitin‒mediated proteolysis and the E3 ubiquitin ligase AMFR can target prM for degradation. Importantly, PIM1 catalyzed phosphorylation of prM at Ser101 and Thr107, and this phosphorylation prevented the proteasome-dependent degradation of prM by impairing its association with AMFR. Therefore, the S101/T107-D phosphorylation mimic mutant of prM was more resistant to PIM1-induced increases in cellular abundance.DiscussionThese findings revealed PIM1 as a critical host factor that is advantageous to ZIKV and revealed that targeting the PIM1‒prM axis is a conducive strategy for controlling ZIKV infection.
Design-related bias in studies investigating diagnostic tests for venous thromboembolic diseases: a systematic review and meta-analysis
Authors: Boschetti Laura , Nilius Henning , Ten Cate Hugo , Wuillemin Walter A. , Faes Livia , Bossuyt Patrick M. , Bachmann Lucas M. , Nagler Michael 
Published: November 2024

BackgroundEarly detection and diagnosis of venous thromboembolism are vital for effective treatment. To what extent methodological shortcomings exist in studies of diagnostic tests and whether this affects published test performance is unknown.ObjectivesWe aimed to assess the methodological quality of studies evaluating diagnostic tests for venous thromboembolic diseases and quantify the direction and impact of design characteristics on diagnostic performance.MethodsWe conducted a literature search using Medline and Embase databases for systematic reviews summarizing diagnostic accuracy studies for five target disorders associated with venous thromboembolism. The following data were extracted for each primary study: methodological characteristics, the risk of bias scored by the QUADAS QUADAS-2 instrument, and numbers of true-positives, true-negatives, false-positives, and false-negatives. In a meta-analysis, we compared diagnostic accuracy measures from studies unlikely to be biased with those likely to be biased.ResultsEighty-five systematic reviews comprising 1’818 primary studies were included. Adequate quality assessment tools were used in 43 systematic reviews only (51%). The risk of bias was estimated to be low for all items in 23% of the primary studies. A high or unclear risk of bias in particular domains of the QUADAS/QUADAS-2 tool was associated with marked differences in the reported sensitivity and specificity.ConclusionsSignificant limitations in the methodological quality of studies assessing diagnostic tests for venous thromboembolic disorders exist, and studies at risk of bias are unlikely to report valid estimates of test performance. Established guidelines for evaluation of diagnostic tests should be more systematically adopted.Systematic Review RegistrationPROSPERO (CRD 42021264912).
Differing perspectives on artificial intelligence in mental healthcare among patients: a cross-sectional survey study
Authors: Reading Turchioe Meghan , Desai Pooja , Harkins Sarah , Kim Jessica , Kumar Shiveen , Zhang Yiye , Joly Rochelle , Pathak Jyotishman , Hermann Alison , Benda Natalie 
Published: November 2024

IntroductionArtificial intelligence (AI) is being developed for mental healthcare, but patients' perspectives on its use are unknown. This study examined differences in attitudes towards AI being used in mental healthcare by history of mental illness, current mental health status, demographic characteristics, and social determinants of health.MethodsWe conducted a cross-sectional survey of an online sample of 500 adults asking about general perspectives, comfort with AI, specific concerns, explainability and transparency, responsibility and trust, and the importance of relevant bioethical constructs.ResultsMultiple vulnerable subgroups perceive potential harms related to AI being used in mental healthcare, place importance on upholding bioethical constructs, and would blame or reduce trust in multiple parties, including mental healthcare professionals, if harm or conflicting assessments resulted from AI.DiscussionFuture research examining strategies for ethical AI implementation and supporting clinician AI literacy is critical for optimal patient and clinician interactions with AI in mental healthcare.
Serum 25-hydroxy vitamin D level is associated with elastography-detected liver fibrosis in patients with type 2 diabetes mellitus in China
Authors: Huang Nan , Su Xianghui , Yu Ting , Wu Xiaodong , Lu Bing , Sun Weixia , Yao Liqin , Wang Maoyun , Wang Yao , Wu Wenxuan , Liu Yingzhao , Yang Ting , Gao Ruidong , Miao Congqing , Li Ling 
Published: November 2024

ObjectiveIn this cross-sectional study including patients with type 2 diabetes mellitus (T2DM) we aimed to explore the relationship between serum 25-hydroxy vitamin (25(OH)D) level and liver steatosis and fibrosis in the Chinese population.MethodsPatients visiting 16 clinical centers with T2DM were recruited. Their liver steatosis and fibrosis status were then assessed using elastography. Factors associated with steatosis and fibrosis were explored using regression analysis. Correlations between serum 25(OH)D levels and other patient characteristics were analyzed using linear regression.ResultsIn total, 1,513 patients with T2DM were included in the study. The prevalence of steatosis and fibrosis was 69.7%, and 34.6%, separately. A lower level of 25(OH)D was detected in patients with liver steatosis compared to those without, although it was not an independent predictor of this condition. However, 25(OH)D level was independently associated with liver fibrosis even when adjusted for age, sex, body mass index, hemoglobin A1c, insulin, and homeostatic model assessment of insulin resistance (OR = 0.964 [0.935-0.993], P = 0.015). When patients were separated into subgroups by sex, a correlation between 25(OH)D and fibrosis was identified in the male group (OR = 0.969 [0.940-0.998], P = 0.038).ConclusionsIn conclusion, this multi-center, cross-sectional study in patients with T2DM showed that serum 25-hydroxy vitamin D level was strongly associated with liver fibrosis and this relationship was more pronounced in male patients.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/, identifier NCT05597709.
Endometrial expression of ERRβ and ERRγ: prognostic significance and clinical correlations in severe endometriosis
Authors: Wang Zhenna , Guo Sang , Xie Yi , Tong Yao , Qi Wei , Wang Zhenhong 
Published: November 2024

BackgroundEndometriosis (EMs) results in approximately 50% of reproductive-age women facing infertility. Currently, no precise model is available to predict successful postoperative pregnancy.MethodsThis study involved 81 patients with severe EMs (stages III and IV) and 38 controls with benign gynecological conditions, matched by age and BMI, diagnosis at Fujian Maternity and Child Health Hospital from January 2018 to December 2019. Relative expression levels of ERRβ and ERRγ mRNA in ectopic and ectopic endometrial tissues were measured using fluorescence quantitative PCR. Serum levels of ERRβ, ERRγ, and fertility-related hormones (AMH, FSH, LH, CA125) were assessed. Correlations were analyzed, and the predictive value of ERRγ for postoperative pregnancy was evaluated using a nomogram based on LASSO and multivariate logistic regression. Internal validation using bootstrapping techniques assessed the nomograms performance, including calibration and DCA.ResultsERRβ and ERRγ mRNA levels from ectopic tissues were significantly reduced in patients with severe EMs compared to controls. High serum CA125 correlated with increased ERRγ mRNA expression in ectopic tissues. ERRγ mRNA expression in ectopic endometrial tissues was negatively correlated with age, BMI, and FSH levels, and positively with AMH and LH/FSH ratio. ERRγ mRNA and FSH were significant predictors of postoperative pregnancy, with the nomogram model showing a Brier score of 0.175 and a consistency statistic of 0.811.ConclusionsERRβ and ERRγ are downregulated in ectopic tissues from severe EMs. Elevated ERRγ mRNA expression and lower FSH levels are predictive factors for successful postoperative pregnancy.
Study on sealing performance of main gate valve of marine nuclear power plant based on fluid-solid-thermal coupling method
Authors: Yuqing Chen , Hang Yu , Shengwei Fu , Ang Li 
Published: November 2024

IntroductionThe main gate valve is a critical component of the coolant system in marine nuclear power plants, yet its integrity is often compromised by leakage, particularly during transient operations. This study employs a fluid-solid-thermal coupling method to numerically investigate the sealing performance of the main gate valve under rapid coolant temperature drops.MethodsThe analysis reveals that thermal shock-induced uneven stress and deformation significantly reduce contact pressure on the sealing surface, leading to leakage.Results and DiscussionNotably, only when the bolt preload reaches the material yield limit can the valve maintain a seal during operation. Furthermore, the study demonstrates that a faster rate of coolant temperature drop exacerbates the leakage. These findings offer valuable insights for optimizing the operation of marine nuclear power plants and enhancing the structural integrity of the main gate valve.
Method for calculating a water surface profile at the watershed scale with little observed data based on ASTER GDEM: a case study in the Naoli River, northeast China
Authors: Tian Lin , Wei Yinying , Wang Sheng , Zhang Guorong , Zhao Chuangjia , Huang Xin , Huang Weiyu 
Published: November 2024

The calculation of a river water surface profile is a very important problem in the field of hydraulic engineering. With the development of research on surface and groundwater coupled simulation, the river water surface profile has become an indispensable boundary condition for simulating the inter-relationship between surface water and groundwater. River channel large-section data are the basic prerequisites for building most hydrodynamic models, and obtaining field data can consume considerable effort and material resources. We extracted river sections using ArcGIS based on the ASTER GDEM data and interpolated the corresponding water levels of different guarantee flow rates in Baoqing and Caizuizi stations. We analyzed the variation of upstream water levels under different Manning coefficients n, and the bed resistance of the Naoli River was determined to be 0.025. In order to ensure the rationality of the model and the reliability of the operation results, three indexes (non-scouring velocity, the shear stress of the riverbed, and the water surface slope) were used to analyze and test the rationality of the simulation results. Ultimately, the calculation of the water surface profile from the Baoqing hydrologic station to the Caizuizi hydrologic station in the Naoli River was achieved using the MIKE 11 hydrodynamics model under the guarantee flow rates of 20%, 50%, 75%, and 95%. Calculating the water surface profile can provide hydrological boundary conditions for surface and groundwater conversion and the combined simulation. Furthermore, the present study can provide a feasible method for calculating a river water surface profile in areas that lack measured section data.