bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case‐Crossover–Based Screening Approach to Identifying Clinically Relevant Drug–Drug Interactions in Electronic Healthcare Data
Authors: Bykov Katsiaryna , Schneeweiss Sebastian , Glynn Robert J. , Mittleman Murray A. , Gagne Joshua J. 
Published: January 2019

We sought to develop a semiautomated screening approach using electronic healthcare data to identify drug–drug interactions (DDIs) that result in clinical outcomes. Using a case‐crossover design with 30‐day hazard and referent windows, we evaluated codispensed drugs (potential precipitants) in 7,801 patients who experienced rhabdomyolysis while on cytochrome P450 (CYP)3A4‐metabolized statins and in 15,147 who experienced bleeding while on dabigatran. Estimates of direct associations between precipitant drugs and outcomes were used to adjust for bias and precipitants’ direct effects. The P values were adjusted for multiple testing using the false discovery rate (FDR). From among 460 drugs codispensed with statins, 1 drug (clarithromycin) generated an alert (adjusted odds ratio (OR) 5.83, FDR < 0.05). From among 485 drugs codispensed with dabigatran, 2 drugs (naproxen and enoxaparin, ORs 2.50 and 2.75; FDR < 0.05) generated an alert. All three signals reflected known pharmacologic interactions, confirming the potential of case‐crossover–based approaches for DDI screening in electronic healthcare data.
A Novel Zinc Luminescent Coordination Polymer Based on a Tetracarboxylate Acid Ligand for the Detection of Nitrobenzene
Authors: Zhao Qiang , Si Chang‐Dai 
Published: January 2019

AbstractA novel 1D Zinc compound, formulated as [Zn(H2L2−)(H2O)]n (1) (H4L = 3‐(3′,5′‐dicarboxyphenyl)pyridine‐2,6‐dicarboxylic acid), is synthesized by a rigid organic multi‐carboxylic acid ligand under hydrothermal conditions. Compound 1 crystallizes in the orthorhombic P212121 space group and exhibits a 1D fishbone‐like chain, exhibiting strong blue fluorescence emission at room temperature upon excitation. Fluorescence titration shows that the emission intensity of the compound 1 varied upon contacting with different solvents or analytes, exhibiting selective emission quenching responses towards nitrobenzene (NB) which suggests that compound 1 is a promising luminescent sensor material for nitrobenzene.
Photocatalytic Reverse Semi‐Combustion Driven by Ionic Liquids
Authors: Qadir Muhammad I. , Zanatta Marcileia , Gil Eduarda S. , Stassen Hubert K. , Gonçalves Paulo , Neto Brenno A. D. , de Souza Paulo E. N. , Dupont Jairton 
Published: January 2019

AbstractThe simple photolysis of CO2 in aqueous solutions to generate CO and/or hydrocarbons and derivatives in the presence of a catalyst is considered to be a clean and efficient approach for utilizing CO2 as a C1 building block. Despite the huge efforts dedicated to this transformation using either semiconductors or homogeneous catalysts, only small improvements of the catalytic activity have been achieved so far. This article reports that simple aqueous solutions of organic salts—denominated as ionic liquids—can efficiently photo‐reduce CO2 to CO without using photosensitizers or sacrificial agents. The system relies on the formation of the [CO2].− intermediate through homolytic C−C bond cleavage in a cation–CO2 adduct of imidazolium‐based ionic liquids (ILs). The system continuously produced CO up to 2.88 mmol g−1 of IL after 40 h of irradiation by using an aqueous solution of 1‐n‐butyl‐3‐methylimidazolium‐2‐carboxylate (BMIm.CO2) IL, representing an apparent quantum yield of 3.9 %. The organophotocatalytic principles of our system may help to develop more simple and efficient organic materials for the production of solar fuels from CO2 under mild conditions, which represents a real alternative to those based on semiconductors and homogeneous metal‐based catalysts.
Power and energy optimization with reduced complexity in different deployment scenarios of massive MIMO network
Authors: Sofi Ishfaq Bashir , Gupta Akhil , Jha Rakesh Kumar 
Published: January 2019

SummaryWith the increase in the number of users, the role of massive MIMO has become more significant. But there is a significant increase in the power and energy consumption in the massive MIMO network for transmission, processing, and reception. Hence, the prior role is to reduce the power consumption and increase the energy efficiency of the network. In this paper, the work is done to reduce the power consumption, while maintaining the reduced complexity in the massive MIMO and small‐cell scenario, and to increase the energy efficiency, by optimizing the number of users and number of transmission antennas in the massive MIMO scenario. This paper has also found out the optimal values of the energy efficiency, number of transmission antennas, and number of users for a massive MIMO network in different deployment scenarios like indoor hotspot, ultradense, dense urban, urban, suburban, and rural areas in both single‐cell scenario and multicell scenario at the base station and user equipment side according to the ITU‐R M.2135 standard.
Curcumin reduces inflammation in knee osteoarthritis rats through blocking TLR4 /MyD88/NF‐κB signal pathway
Authors: Zhang Yun , Zeng Yu 
Published: January 2019

Abstract

Preclinical Research & Development

Curcumin has been shown to possess a series of beneficial effects, such as antiinflammatory, antioxidant, analgesic, and promoting healing. However, the effect and relative mechanism of curcumin on knee osteoarthritis (OA) have not been elucidated. The aim of this study is to explore the protective effect of curcumin on monosodium iodoacetate (MIA)‐induced OA. Forty‐eight rats were randomized into four experimental groups: control group, OA group, OA + PBS group, and OA + curcumin group, respectively. A single intraarticular injection of MIA was applied to establish the rat model of knee OA. Hematoxylin–eosin staining was used to evaluate histological changes of knee joint. The paw withdrawal threshold was collected and the expression of synovial fluid cytokine levels was measured by ELISA. The protein expression of TRL‐4, MyD88, p‐IκBα, NF‐κB, TNF‐α, IL‐1β, and IL6 was measured by western blot. Treating with curcumin can significantly reduce joint diameter and Mankin's score, and increase the paw withdrawal threshold. The expression of synovial fluid inflammatory biomarkers, IL‐6, IL‐1β, and TNF‐α in the OA + curcumin group were lower than that in OA and OA + PBS group. The protein expression of the TLR4 receptor was increased in the OA, OA + PBS, and OA + curcumin group compared to the control group. However, curcumin treatment can significantly decrease the expression of MyD88, p‐IκBα, NF‐κB, TNF‐α, IL‐1β, and IL6 in OA + curcumin group. These findings may indicate that curcumin could block TLR4/NF‐κB signal pathway, and reduce inflammation level to prevent knee wound in OA rats. Curcumin may be a feasible kind of medicament in the treatment of knee OA.
Vegetation phenology and nest survival: Diagnosing heterogeneous effects through time
Authors: Ringelman Kevin M. , Skaggs Cassandra G. 
Published: January 2019

AbstractBirds should select nest sites that minimize predation risk, but understanding the influence of vegetation on nest survival has proven problematic. Specifically, the common practice of measuring vegetation on nest fate date can overestimate its effect on nest survival, simply because vegetation at hatched nests grows for a longer period of time than vegetation at nests that were depredated. Here, we sampled the literature to determine the prevalence of this bias in studies of duck breeding ecology. We then used survival data collected from ~2,800 duck nests to empirically evaluate evidence of bias in four different vegetation metrics: vegetation density measured when the nest was found, density when the nest was fated, and date‐corrected regression residuals of these two. We also diagnosed the magnitude of vegetation effects on nest survival by restricting our analysis to only nests which were fated contemporaneously (thereby removing potential bias in the timing of measurement). Finally, we examined whether systematic phenological differences exist between vegetation at hatched and depredated nests that have the potential to further obfuscate the relationship between vegetation and nest survival. We found evidence for a true‐positive effect of vegetation density on nest survival that appeared to be inflated when using raw vegetation measurements collected at fate date. However, taken in combination with the literature review, our results suggest that the majority of duck nesting studies have evaluated the role of vegetation on nest survival using a relatively less biased metric—vegetation density when the nest was found. Finally, we found that over the course of a nesting attempt, vegetation increased in density at successful nests, but decreased in density at depredated nests. As a consequence, duck researchers using vegetation data collected when the nest was found may actually be underestimating the magnitude of the effect. This seasonal change potentially points to an important new metric for understanding predation risk, but further experimental research is required to fully eliminate potential biases in the timing of vegetation measurements.
Metal‐bonding‐based hermetic wafer‐level MEMS packaging technology using in‐plane feedthrough: Hermeticity and high frequency characteristics of thick gold film feedthrough
Authors: Moriyama Masaaki , Suzuki Yukio , Totsu Kentaro , Hirano Hideki , Tanaka Shuji 
Published: January 2019

AbstractAu–Au‐bonding‐based wafer‐level vacuum packaging technology using in‐plane feedthrough of thick Au signal lines was developed for high‐frequency micro electromechanical system (RF MEMS). Compared with conventional technology based on glass frit bonding, the developed technology is advantageous in terms of smaller width of sealing frames, lower process temperature, and smaller amount of degas. To guarantee the hermetic sealing, the adhesion between the thick Au lines and a SiOx dielectric frame is improved by an Al2O3 interlayer by atomic layer deposition. The steps of the dielectric frame above the thick Au lines are absorbed by an electroplated Au seal ring planarized by fly cutting. The thermocompression bonding of the Au seal rings of 20‐100 μm width was done at 300 ºC. A cavity pressure of about 500 Pa or lower was measured by “zero balance method” using Si diaphragms. Vacuum sealing was maintained for more than 19 months, and the leak rate is less than 8×10‐16 Pa m3/s. The isolation of open signal lines was measured up to 10 GHz for different designs of the sealing ring and SiOx dielectric frame. The influence of the in‐plane feed through to the isolation is as low as 2‐3 dB, if the width of the sealing ring is 20 μm and the thickness of SiOx dielectric frame is larger than 10 μm. The developed wafer‐level packaging technology is ready for applications to an radio frequency (RF) MEMS switch.
Fibromyalgia: A misconnection in a multiconnected world?
Authors: Perrot Serge 
Published: January 2019

AbstractFibromyalgia represents a condition still controversial in its entity, pathophysiology, diagnosis and management (Figure ). In a world where everybody is connected, and everybody is sharing their own image, fibromyalgia (FM) represents the emblematic pathology of misconnection and lack of specific biomarker. FM is an invisible experience with all normal tests and analyses, without any visible biomarker to exhibit to healthcare professionals, colleagues and relatives. In this context, we propose to consider FM as a disease of misconnection at different levels: misconnection with society, misconnection with healthcare professionals, misconnection with pathophysiological concepts, misconnection between brain and body. The concept of misconnection defines FM in a different and holistic view and proposes different views of assessment, management and representation:

FM pathophysiology: the desynchronization of brain and body
FM recognition: the broken link between patients and physicians
FM assessment: merging the body and mind for an optimal diagnosis and management
FM treatment: re‐establishing the good connections at different levels
We hope to reconnect FM patients with all healthcare providers, help FM patients reconnect with their painful body and integrate FM into regular medical practice.SignificanceThe concept of misconnection defines FM in a different and holistic view, and propose different views of assessment, management and representation.
Chromosome territories and the global regulation of the genome
Authors: Fritz Andrew J. , Sehgal Nitasha , Pliss Artem , Xu Jinhui , Berezney Ronald 
Published: January 2019

AbstractSpatial positioning is a fundamental principle governing nuclear processes. Chromatin is organized as a hierarchy from nucleosomes to Mbp chromatin domains (CD) or topologically associating domains (TADs) to higher level compartments culminating in chromosome territories (CT). Microscopic and sequencing techniques have substantiated chromatin organization as a critical factor regulating gene expression. For example, enhancers loop back to interact with their target genes almost exclusively within TADs, distally located coregulated genes reposition into common transcription factories upon activation, and Mbp CDs exhibit dynamic motion and configurational changes in vivo. A longstanding question in the nucleus field is whether an interactive nuclear matrix provides a direct link between structure and function. The findings of nonrandom radial positioning of CT within the nucleus suggest the possibility of preferential interaction patterns among populations of CT. Sequential labeling up to 10 CT followed by application of computer imaging and geometric graph mining algorithms revealed cell‐type specific interchromosomal networks (ICN) of CT that are altered during the cell cycle, differentiation, and cancer progression. It is proposed that the ICN correlate with the global level of genome regulation. These approaches also demonstrated that the large scale 3‐D topology of CT is specific for each CT. The cell‐type specific proximity of certain chromosomal regions in normal cells may explain the propensity of distinct translocations in cancer subtypes. Understanding how genes are dysregulated upon disruption of the normal “wiring” of the nucleus by translocations, deletions, and amplifications that are hallmarks of cancer, should enable more targeted therapeutic strategies.
Characterization of human telomerase reverse transcriptase promoter methylation and transcription factor binding in differentiated thyroid cancer cell lines
Authors: Avin Brittany A. , Wang Yongchun , Gilpatrick Timothy , Workman Rachael E. , Lee Isac , Timp Winston , Umbricht Christopher B. , Zeiger Martha A. 
Published: January 2019

AbstractTelomerase reverse transcriptase (TERT) activation plays an important role in cancer development by enabling the immortalization of cells. TERT regulation is multifaceted, and its promoter methylation has been implicated in controlling expression through alteration in transcription factor binding. We have characterized TERT promoter methylation, transcription factor binding, and TERT expression levels in five differentiated thyroid cancer (DTC) cell lines and six normal thyroid tissue samples by targeted bisulfite sequencing, ChIP‐qPCR, and qRT‐PCR. DTC cell lines express varying levels of TERT and exhibit TERT promoter methylation patterns similar to patterns seen in other telomerase positive cancer cell lines. The minimal promoter immediately surrounding the transcription start site is hypomethylated, while further upstream portions show dense methylation. In contrast, the TERT promoter in normal thyroid tissue is largely unmethylated throughout and expresses TERT minimally. Transcription factor binding is also affected by TERT mutation status. The E‐twenty‐six (ETS) factor GABPA exhibits TERT binding in the TERT mutant DTC cells only, and allele‐specific methylation patterns at the minimal promoter were observed as well, which may indicate allele‐specific factor recruitment at the minimal promoter. Furthermore, we identified binding sites for activators MYC and GSC in the hypermethylated upstream region, pointing to its possible importance in TERT regulation. Overall, TERT expression and telomerase activity depend on the interplay of multiple regulatory mechanisms including TERT promoter methylation, mutation status, and recruitment of transcription factors. This work explores of the interplay between these regulatory mechanisms and offers insight into cellular control of active telomerase in human cancer.
Aqueous carbonation of MgSO4 with (NH4)2CO3 for CO2 sequestration
Authors: Deng Chenhui , Liu Weizao , Chu Guanrun , Luo Dongmei , Zhang Guoquan , Wang Liming , Yue Hairong , Liang Bin , Li Chun 
Published: January 2019

AbstractMineral carbonation is an important technical option for the effective reduction of CO2 emissions. Natural magnesium‐containing minerals, such as serpentine and blast furnace slag (BFS), have recently been used for CO2 storage with an indirect carbonation route using ammonium sulfate. In this study, the effects of the feeding mode and process parameters on the magnesium conversion, product phase, and morphology during the aqueous carbonation of MgSO4 with ammonium carbonate solution were investigated in detail. The results showed that the carbonation ratio with a parallel feed was higher than the forward and reverse feed by about 3–5% with a limited reaction time, and the product size was more uniform. The phase and morphology of the products were affected significantly by the temperature. The highest carbonation ratio appeared at 40°C because only 75% of magnesium was carbonated if hydromagnesite was produced. When the mole ratio of (NH4)2CO3 to MgSO4 was 2:1 and the concentration of magnesium sulfate was higher than 0.4 mol·L−1, the carbonated products contain ammonium magnesium carbonate, and the ammonia should be recovered by selective thermal decomposition. When the mole ratio decreased to 1.5:1, only nesquehonite appears with high crystallinity and uniform size. The optimized conditions were therefore selected as 40°C, a mole ratio of 1.5:1, and magnesium sulfate concentration of 0.7 mol·L−1. Under these conditions the carbonation ratio reached 88%. Additionally, the optimal initial pH of MgSO4 solution was 9.5 (the product was nesquehonite at low pH) while the hydromagnesite will be produced at higher pH (pH more than 10). © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd.
Protocol driven outcomes in renal parathyroid surgery
Authors: Walsh Nathaniel J. , Caten Alexander J. , White John J. , Terris David J. 
Published: January 2019

AbstractBackgroundPatients who require surgery for renal hyperparathyroidism represent a special population that is at high risk for postoperative complications. To optimize their treatment, we developed a multidisciplinary approach to the perioperative management of these patients undergoing parathyroidectomy.MethodsThe Augusta University endocrine surgery parathyroid database was interrogated to identify dialysis‐dependent patients undergoing parathyroidectomy from 2005 to 2015. Numerous clinical parameters were quantified. Patients were stratified into protocol patients and nonprotocol patients.ResultsA total of 42 patients undergoing renal parathyroidectomy who met the inclusion criteria were identified. Serious adverse events were nearly twice as common in the patients not treated on protocol. The length of stay was nearly 2 days shorter in the protocol group. Lowest calcium level and ionized calcium was higher in the protocol cohort despite a lower postoperative parathyroid hormone. The protocol group had fewer laboratory draws.ConclusionImplementation of a multidisciplinary renal hyperparathyroidism protocol has resulted in improved perioperative outcomes.
The influence of groundwater representation on hydrological simulation and its assessment using satellite‐based water storage variation
Authors: Huang Zhongwei , Tang Qiuhong , Lo Min‐Hui , Liu Xingcai , Lu Hui , Zhang Xuejun , Leng Guoyong 
Published: January 2019

AbstractThe interaction between surface water and groundwater is an important aspect of hydrological processes. Despite its importance, groundwater is not well represented in many land surface models. In this study, a groundwater module with consideration of surface water and groundwater dynamic interactions is incorporated into the distributed biosphere hydrological (DBH) model in the upstream of the Yellow River basin, China. Two numerical experiments are conducted using the DBH model: one with groundwater module active, namely, DBH_GW and the other without, namely, DBH_NGW. Simulations by two experiments are compared with observed river discharge and terrestrial water storage (TWS) variation from the Gravity Recovery and Climate Experiment (GRACE). The results show that river discharge during the low flow season that is underestimated in the DBH_NGW has been improved by incorporating the groundwater scheme. As for the TWS, simulation in DBH_GW shows better agreement with GRACE data in terms of interannual and intraseasonal variations and annual changing trend. Furthermore, compared with DBH_GW, TWS simulated in DBH_NGW shows smaller decreases during autumn and smaller increases in spring. These results suggest that consideration of groundwater dynamics enables a more reasonable representation of TWS change by increasing TWS amplitudes and signals and as a consequence, improves river discharge simulation in the low flow seasons when groundwater is a major component in runoff. Additionally, incorporation of groundwater module also leads to wetter soil moisture and higher evapotranspiration, especially in the wet seasons.
Identification and mapping of riverbed sediment facies in the Columbia River through integration of field observations and numerical simulations
Authors: Hou Zhangshuan , Scheibe Timothy D. , Murray Christopher J. , Perkins William A. , Arntzen Evan V. , Ren Huiying , Mackley Robert D. , Richmond Marshall C. 
Published: January 2019

AbstractIn the Hanford Reach of the Columbia River, a thin layer of recent alluvium overlies the sedimentary formations that comprise the unconfined groundwater aquifer. Experimental and modelling studies have demonstrated that this alluvial layer exerts significant control on the exchange of groundwater and surface water (hydrologic exchange flux), and is associated with elevated levels of biogeochemical activity. This layer is also observed to be strongly heterogeneous, and quantifying the spatial distribution of properties over the range of scales of interest is challenging. Facies are elements of a sediment classification scheme that groups complex geologic materials into a set of discrete classes according to distinguishing features. Facies classifications have been used as a framework for assigning heterogeneous material properties to grid cells of numerical models of flow and reactive transport in subsurface media. The usefulness of such an approach hinges on being able to relate facies to quantitative properties needed for flow and reactive transport modelling, and on being able to map facies over the domain of interest using readily available information. Although aquifer facies have been used in various modelling contexts, application of this concept to riverbed sediments is relatively new. Here, we describe an approach for categorizing and mapping recent alluvial (riverbed) sediments based on the integration of diverse observations with numerical simulations of river hydrodynamics. The facies have distinct distributions of sediment texture that correspond to variations in hydraulic properties, and therefore provide a useful framework for assigning heterogeneous properties in numerical simulations of hydrologic exchange flows and biogeochemical processes.