bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of post-operative foveal location and microstructural changes after pars plana vitrectomy for rhegmatogenous retinal detachment using enhanced-depth imaging optical coherence tomography
Authors: Azaizy Mostafa Mahmoud Eid Al , Khalil Hossam Eldin Mohamed , Leila Mahmoud , Akl Nour Salah , Mohammed Sahar Ibrahim 
Published: November 2024

Abstract
Background
Patients who had successful rhegmatogenous retinal detachment (RRD) surgery often complained of metamorphopsia due to postoperative fovea displacement and alteration of the foveal microstructure. The papillo-foveal distance (PFD) is correlated bilaterally. Therefore, PFD from the fellow healthy eye could be used to determine the change of foveal position in eyes with successful RRD repair. Ultra-high-resolution optical coherence tomography (UHR-OCT) could explain incomplete visual recovery by demonstrating foveal misalignment and changes in foveal microstructure. The rationale of the study is to assess the changes in the foveal location and microstructural layers after successful retinal reattachment and correlate them with visual dysfunction.

Patients and methods
A prospective interventional cross-sectional controlled study included patients who had successful retinal reattachment and complained of defective vision or metamorphopsia. The primary outcome measure is to evaluate the post-operative foveal location. The secondary outcome measures are the assessment of metamorphopsia, the evaluation of the foveal microstructural changes, and the correlation between foveal shift, metamorphopsia, foveal microstructure, and visual function. We used a standard Amsler chart to detect subjective metamorphopsia and a modified Amsler chart to quantify metamorphopsia. We used the enhanced-depth imaging optical coherence tomography (EDI-OCT) to detect changes in PFD and the foveal microstructure. p < 0.05.

Results
The study included 50 study eyes and 50 control eyes. The male gender constituted 70%. The mean age was 53 years. The mean baseline BCVA was 0.001. The incidence of foveal displacement was 70%. Disorganized retinal inner layers (DRIL) occurred in 56% of eyes, and disorganized retinal outer layers (DROL) occurred in 72% of eyes. The mean postoperative BCVA was 0.3. The subjective metamorphopsia was mild in 39%, moderate in 24%, severe in 33%, and very severe in 3% of eyes. The mean quantitative metamorphopsia was 587 mm. PVR correlated significantly with the foveal shift. DROL correlated significantly with subjective metamorphopsia. There was a statistically significant difference between subjective metamorphopsia and quantitative metamorphopsia.

Conclusion
Foveal displacement and metamorphopsia after successful retinal reattachment pose significant morbidity. UHR-OCT is pivotal in evaluating the anatomical outcome after successful retinal re-attachment surgery and its relation to visual function.
Predicting the therapeutic role and potential mechanisms of Indole-3-acetic acid in diminished ovarian reserve based on network pharmacology and molecular docking
Authors: Zheng Jianxiu , Wang Liyan , Liu Ahui , Shen Haofei , Wang Bin , Jiang Yanbiao , Jing Panpan , Guan Defeng , Yu Liulin , Zhang Xuehong 
Published: November 2024

Abstract
Background
Indole-3-acetic acid (IAA), an indole analog produced by intestinal microorganisms metabolizing tryptophan, has anti-inflammatory and antioxidant properties and thus has potential applications in ovarian protection, although the exact mechanism is unknown. The present study preliminarily investigated the pharmacological mechanism of IAA in alleviating diminished ovarian reserve (DOR) by network pharmacology and molecular docking.

Methods
Relevant target proteins of IAA were searched in SwissTargetPrediction, PharmMapper, TargetNet, BATMAN-TCM, and SuperPred databases. The potential targets of DOR were obtained from GeneCards, DisGenet, OMIM, and Drugbank databases. Both common targets were then imported into the String website to construct a PPI network, and these targets were analyzed for GO and KEGG enrichment. Finally, we utilized molecular docking to validate the possible binding conformations between IAA and the candidate targets. We used in vitro experiments to preliminarily investigate the effects of IAA on DOR.

Results
We obtained 88 potential targets for IAA and DOR interaction. We received 16 pivotal targets by constructed protein interaction screening. KEGG enrichment analysis mainly included the AGE-RAGE signaling pathway, IL-17 signaling pathway, Chemical carcinogenesis—reactive oxygen species in diabetic complications, etc. GO functional analysis showed that IAA treatment of DOR may involve biological processes such as response to external stimuli, hypoxia, gene expression, and regulation of enzyme activity. Molecular docking and in vitro experiments further revealed the potential effects of IAA on MMP2, TNF-α, AKT1, HSP90AA1, and NF-κ B.

Conclusion
We preliminarily revealed the potential protective effects of IAA against DOR through multiple targets and pathways, which provides a new research strategy for the molecular mechanism of IAA to alleviate DOR in the future. However, further studies need to demonstrate whether IAA can be used as a compound to prevent and treat DOR.
The effect of state gratitude on interpersonal trust under cognitive reappraisal among Chinese college students
Authors: Abbasi Najam ul Hasan , Yi Li Zi , Yong Liu , Xia Mi Xue , Hadi Abdul 
Published: November 2024

Abstract
Objectives
This article starts with increasing emotions through cognitive reappraisal and explores the impact of state gratitude emotions on interpersonal trust among college students under cognitive reappraisal.

Method
In study 1, we used a questionnaire survey and experimental design to collect data, which we processed/analyzed using SPSS 23.0. We employed, the Rotter Interpersonal Trust Scale (ITS), as adapted by Xu Huiyan, consisting of 25 items, to measure the interpersonal trust levels among college students and to explore the potentially significant differences in interpersonal trust levels among the students based on their demographic variables, including gender. We collected 347 survey questionnaires, with 143 from males and 204 from females, with a mean age of 20.93 (SD = 2.703). In study 2, we utilized a univariate inter-subject experimental design, with the independent variable being the state gratitude emotion (awakened vs. not awakened) under cognitive reappraisal, and the dependent variable was the level of interpersonal trust. Thirty participants participated in the pre-experiment, followed by 119 participants in the formal experiment to assess the impact of state gratitude emotion on interpersonal trust among college students, using motivation reappraisal strategy (t = − 4.028, p < 0.01).

Results
This study found that (1) the overall interpersonal trust of college students was moderate to low (M = 38.01, SD = 9.13); (2) no significant differences in interpersonal trust levels were found among college students based on gender, grade, and whether they had children; however, the significant differences in interpersonal trust levels were observed among college students based on their the area of residence (F = 3.675, p < 0.05), school type (F = 3.04, p < 0.05), and family type (t = − 3.034, p < 0.01); (3) cognitive reappraisal has been shown to enhance individuals’ gratitude emotions in situations, thereby, raising their interpersonal trust level.

Conclusions
We conclude that cognitive reappraisal enhances individuals’ positive emotions and levels of interpersonal trust in social interactions, offering a reference for promoting positive emotions and interpersonal trust levels among college students.
Assessing the impact of COVID-19 on outpatient psychiatric population well-being and symptomology utilizing COVID-19 Events Checklist (CEC) and Measurement Based Care
Authors: Jones Sydney B. , Ko Hayoung , Gatto Alyssa J. , Kablinger Anita S. , Sharp Hunter D. , Cooper Lee D. , Tenzer Martha M. , O’Brien Virginia C. , McNamara Robert S. 
Published: November 2024

Abstract
Background
This study examines the impact of SARS-CoV-2 (i.e., coronavirus, COVID, COVID-19) using data from a measurement-based care (MBC) system utilized in an outpatient psychiatric clinic providing telemedicine care. A novel Patient Rated Outcome Measure (PROM), the COVID-19 Events Checklist (CEC) was administered in a hospital system based ambulatory clinic beginning April 2020 to track COVID-19-19’s impact on patients’ mental, emotional, and health-related behaviors during the pandemic. The study (1) provides descriptive CEC data, and (2) compares CEC results with PROMs evaluating anxiety (Generalized Anxiety Disorder-7; GAD-7), depression (Patient Health Questionnaire; PHQ-9), and psychological distress (Brief Adjustment Scale-6; BASE-6).

Methods
This retrospective observational study included patient intake data collected from April 2020 to March 2021. Patient (N = 842) reports on the CEC’s five domain questions were aggregated to calculate average reports of COVID-19 related impacts at intake over the initial 12 months of the pandemic. Trends in COVID-19 related impacts were examined, and non-aggregated scores on the PHQ-9, GAD-7, and BASE-6 were compared to primary dichotomous (yes/no) CEC survey questions via Wilcoxon rand sum testing.

Results
Results capture the relationship between COVID-19 exposure, COVID-19- related sequelae and behaviors, and psychological symptom severity. Specifically, Wilcoxon rank-sum tests indicate that social determinants of health (SDOH), negative mental health impacts, and positive coping skill use were significantly associated with psychological symptomatology including overall psychological functioning via the BASE-6, anxiety via the GAD-7, and depressive symptoms via the PHQ-9. Results regarding SDOH were as follows: BASE-6 (w = 44,005, p < 0.001), GAD-7 (w = 44,116, p < 0.001), and PHQ-9 (w = 43,299, p < 0.001). Regarding negative mental health outcomes, the results were: BASE-6 (w = 38,374, p < 0.001), GAD-7 (w = 39,511, p < 0.001), and PHQ-9 (w = 40,154, p < 0.001). As the initial year of the pandemic elapsed, incoming patients demonstrated increased rates of suspected or confirmed exposure to COVID-19, (+2.29%, t = 3.19, p = 0.01), reported fewer negative impacts of COVID-19 on SDOH (−3.53%, t= −2.45, p = 0.034), and less engagement in positive coping strategies (−1.47%, t = −3.14, p = 0.010).

Conclusions
Psychosocial factors related to COVID-19 are discussed, as well as opportunities for further research on the relationship between psychological symptomatology and the impact of COVID-19 on health-related behaviors.
XII International Mycological Congress: report of Congress action on nomenclature proposals relating to fungi
Authors: May Tom W. , Bensch Konstanze , Groenewald Johannes Z. , Houbraken Jos , Rossman Amy Y. 
Published: November 2024

AbstractProcedures, appointments and outcomes of the Fungal Nomenclature Session (FNS) of the XII International Mycological Congress (IMC12) are summarized, including the composition of the Fungal Nomenclature Bureau and the Nominating Committee of the IMC. Between 124 and 322 mycologists attended the three sessions of the FNS, at which formal proposals to amend Chapter F of the International Code of Nomenclature for algae, fungi, and plants were debated. The 15 proposals considered included eight "from the floor", five of which were withdrawn prior to the FNS. One of the withdrawn proposals was directed to the Editorial Committee for Fungi, in relation to adding examples of best practice when citing living cultures as types. Among the seven proposals published in Taxon, one proposal with a high “no” vote in the Guiding Vote was not re-introduced. Discussion on one proposal led to the authorization of a Special-purpose Committees on “Genomes as Types for Fungi”. For the eight proposals that were put to a vote, two proposals were rejected and six proposals were accepted. The accepted proposals: (1) clarified that a proposal to conserve a name with a conserved type does not require citation of a typification identifier; (2) clarified procedures to protect and reject names of fungi; (3) removed the need to list synonyms of protected names in the Code appendices; (4) clarified that an earlier homonym of a sanctioned name remains unavailable if the sanctioned name is rejected outright; (5) recommended that culture collections or biological resource centres where cultures are lodged should be “public”; and (6) recommended that when original type cultures are lost, neotypification should utilize the progeny of ex-type cultures. Appointments made by the FNS included the Secretary of the Fungal Nomenclature Bureau for IMC13, the officers and members of the Editorial Committee for Fungi, and the officers and members of the Permanent Nomenclature Committee for Fungi. Decisions and appointments of the FNS were ratified in a resolution accepted by the plenary session of the Congress.
Targeted delivery of extracellular vesicles: the mechanisms, techniques and therapeutic applications
Authors: Zhao Shuang , Di Yunfeng , Fan Huilan , Xu Chengyan , Li Haijing , Wang Yong , Wang Wei , Li Chun , Wang Jingyu 
Published: November 2024

AbstractExtracellular vesicles (EVs) are cell-derived vesicles with a phospholipid bilayer measuring 50–150 nm in diameter with demonstrated therapeutic potentials. Limitations such as the natural biodistribution (mainly concentrated in the liver and spleen) and short plasma half-life of EVs present significant challenges to their clinical translation. In recent years, growing research indicated that engineered EVs with enhanced targeting to lesion sites have markedly promoted therapeutic efficacy. However, there is a dearth of systematic knowledge on the recent advances in engineering EVs for targeted delivery. Herein, we provide an overview of the targeting mechanisms, engineering techniques, and clinical translations of natural and engineered EVs in therapeutic applications. Enrichment of EVs at lesion sites may be achieved through the recognition of tissue markers, pathological changes, and the circumvention of mononuclear phagocyte system (MPS). Alternatively, external stimuli, including magnetic fields and ultrasound, may also be employed. EV engineering techniques that fulfill targeting functions includes genetic engineering, membrane fusion, chemical modification and physical modification. A comparative statistical analysis was conducted to elucidate the discrepancies between the diverse techniques on size, morphology, stability, targeting and therapeutic efficacy in vitro and in vivo. Additionally, a summary of the registered clinical trials utilizing EVs from 2010 to 2023 has been provided, with a full discussion on the perspectives. This review provides a comprehensive overview of the mechanisms and techniques associated with targeted delivery of EVs in therapeutic applications to advocate further explorations of engineered EVs and accelerate their clinical applications.
Moving toward automated µFTIR spectra matching for microplastic identification: addressing false identifications and improving accuracy
Authors: Kozloski Rachel , Cowger Win , Arienzo Monica M. 
Published: November 2024

AbstractInfrared spectroscopy is a widely used tool for studying microplastics and identifying microparticles. Researchers rely on spectral libraries to differentiate between synthetic and natural materials. Unfortunately, spectral library matching is not perfect, and best practices require researchers to use time consuming, manual peak matching to assess spectral matches. Moving toward automated matching requires increased confidence in the matching process. Using spectra matching software may increase the efficiency of particle identification, however some matching strategies may confuse natural materials such as cotton, silk, and plant matter with common classes of synthetics such as polyesters and polyamides. In this experiment, we prepared 22 pristine sample materials from natural and synthetic sources and measured micro-Fourier transform infrared (µFTIR) spectra in transmission mode for each sample using a Thermo Nicolet iN10 MX instrument. The collected spectra were then input into two spectral library matching systems (Omnic Picta and Open Specy), using a total of five identification routines. Next, we placed a subset of four pristine microplastic materials in a biologically active river system for two weeks to simulate environmental samples. These simulated environmental samples were processed using 10% hydrogen peroxide for 24 h to remove organic contamination and then identified using the strongest performing library. We found that libraries with fewer sample spectra produced lower correlation matches and that using derivative correction greatly reduced the number of inaccuracies in identifying materials as either natural or synthetic. We also found that environmental fouling reduced the correlation value of library matches when compared to pristine particles, however the effect was not consistent across the four materials tested. Overall, we found that the accuracy of automated library matching in the tested systems and processing routines varied from 64.1 to 98.0% for distinguishing between natural and synthetic materials, and that a high Hit Quality Index (HQI) did not always correlate with accuracy. These results are important for the microplastic field, demonstrating a need to rigorously test spectral libraries and processing routines with known materials to ensure identification accuracy.
Hyperthermic Intraperitoneal Chemotherapy in Platinum-Sensitive Recurrent Ovarian Cancer: A Randomized Trial on Survival Evaluation (HORSE; MITO-18)
Authors: Fagotti Anna , Costantini Barbara , Fanfani Francesco , Giannarelli Diana , De Iaco Pierandrea , Chiantera Vito , Mandato Vincenzo , Giorda Giorgio , Aletti Giovanni , Greggi Stefano , Perrone A. Myriam , Salutari Vanda , Trozzi Rita , Scambia Giovanni 
Published: November 2024

PURPOSE
To investigate whether the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to secondary cytoreductive surgery (SCS) without neoadjuvant chemotherapy has a benefit on progression-free survival (PFS), as opposed to SCS alone in patients with platinum-sensitive recurrent epithelial ovarian cancer (platinum-free interval, >6 months).

METHODS

This was a multicenter randomized phase III study. Random assignment was performed at the time of surgery in cases with residual tumor ≤0.25 cm. HIPEC with cisplatin (CDDP) 75 mg/m
2
for 60 minutes at 41.5°C was administered at the end of surgery in the experimental arm. Both groups received postoperative platinum-based chemotherapy. The primary end point was PFS. The safety profile and postrecurrence survival (PRS) were the secondary end points.

RESULTS
A total of 167 patients underwent random assignment, 82 patients to SCS plus HIPEC (experimental arm) and 85 to SCS alone (control arm). The median follow-up was 83 months (IQR, 64-102). The median PFS was 23 months (95% CI, 17 to 29) in the group that underwent surgery alone and 25 months (95% CI, 18 to 32) in the group that underwent cytoreductive surgery with HIPEC. The probability of PRS at 5 years was 61.6% (95% CI, 50.8 to 72.4) in the SCS group and 75.9% (95% CI, 66.5 to 85.3) in the SCS plus HIPEC group. The incidence of postoperative adverse events of any grade was similar between the two groups.

CONCLUSION
The addition of HIPEC to complete or nearly complete primary SCS did not confer a benefit in terms of PFS in patients with platinum-sensitive peritoneal recurrence.
Physiology and Pharmacology of Effects of GLP-1-based Therapies on Gastric, Biliary and Intestinal Motility
Authors: Jalleh Ryan J , Marathe Chinmay S , Rayner Christopher K , Jones Karen L , Umapathysivam Mahesh M , Wu Tongzhi , Quast Daniel R , Plummer Mark P , Nauck Michael A , Horowitz Michael 
Published: November 2024

Abstract
Glucagon-like peptide-1 (GLP-1) receptor agonists and the dual GLP-1- and glucose-dependent insulinotropic polypeptide receptor co-agonist tirzepatide (referred to here collectively as “GLP-1-based therapy”) are incretin-based therapies being used increasingly in the management of both type 2 diabetes and obesity. They are now recognized to have beneficial effects beyond improved glycemic control and weight loss, including cardiovascular and renal protection. GLP-1-based therapy also slows gastric emptying, which has benefits (lowering postprandial glucose), but also potential risks (eg, hypoglycemia in individuals on insulin or sulphonylurea therapy). Their effects on the gallbladder may also be beneficial, contributing to reducing postprandial triglycerides, but they also potentially increase the risk of biliary disease. In this review, we summarize the effects of GLP-1 and incretin-based therapeutics on gastric, biliary and small intestinal function. An improved understanding of these effects will optimize the use of these drugs.
Outcomes Associated with a Patient Blood Management Program in Major Obstetric Hemorrhage: A Retrospective Cohort Study
Authors: Ansari Tarek , Wani Saleema , Hofmann Axel , Shetty Nanda , Sangani Kanan , Stamp Clifford J. , Murray Kevin , Trentino Kevin M. 
Published: November 2024

BACKGROUND:
Obstetric patient blood management (PBM) strategies were used at Corniche Hospital in 2018, initially focusing on minimizing bleeding, with other clinical strategies implemented incrementally. This study assesses program outcomes in patients with major obstetric hemorrhage of 2000 mL or greater.

METHODS:
A retrospective study of 353 women admitted to The Corniche Hospital between 2018 and 2023 who experienced major obstetric hemorrhage of 2000 mL or greater. The primary outcome measure was units of red blood cell (RBC), fresh-frozen plasma (FFP), and platelet units transfused. Secondary outcomes included pretransfusion hemoglobin in patients with no active bleeding, hemoglobin levels 3 weeks postdischarge, anemia predelivery, blood product-acquisition cost savings, mortality, composite morbidity (transfusion reaction, acute lung injury, thrombosis, sepsis, postpartum hysterectomy), hospital and high-dependency unit length of stay, and all-cause emergency readmissions within 28 days.

RESULTS:
Comparing baseline (2018) with the final year (2023), the mean units of RBCs, FFP, and platelets transfused per admission decreased from 4.18 to 0.67 (P-trend <.001), resulting in blood acquisition savings of US$ 175,705. Over the same period the percentage of women anemic predelivery decreased from 40.3% to 23.8% (P-trend = 0.015) and the mean pretransfusion hemoglobin level in nonactively bleeding patients decreased from 7.54 g/dL to 6.35 g/dL (P-trend < .001). The mean hemoglobin rise 3 weeks postdischarge increased from 2.41 g/dL in 2018 to 4.26 g/dL in 2023. There were no changes in adjusted composite morbidity, hospital, or high-dependency unit length of stay.

CONCLUSIONS:
In women with a major obstetric hemorrhage of 2000 mL or greater, the implementation of an obstetric PBM program was associated with reduced blood product utilization, reduced costs, reduced anemia, and increased hemoglobin rise postdischarge.