bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efforts to overcome hypoxia condition in Balb/c mouse macrophages after intraperitoneal SRBC immunization
Authors: Sarsanti Pungguri Ayu Nega , Sadikin Mohamad , Jusman Sri Widia Azraki 
Published: May 2019

BACKGROUND Activated macrophages require increased oxygen to destroy foreign bodies, leading to an increase in the levels of reactive oxygen species (ROS). Therefore, macrophages would experience hypoxic and oxidative stress conditions at the same time. Thus, this study was aimed to evaluate the mechanism of the activated macrophages to overcoming this dual condition.METHODS The activated macrophages were harvested from the intraperitoneal cavities of 18 BALB/c mice immunized with 2% sheep red blood cells (SRBCs). The macrophage suspension was divided into four groups: control, 24, 48, and 72 hours after-immunization groups. The expressions of hypoxia-inducible factor (HIF)-1α, HIF-2α, and cytoglobin (Cygb), as markers for hypoxic condition, were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), whereas peroxisome proliferator-activated receptor gamma coactivator (PGC-1α) protein as a marker for mitochondrial biogenesis and aerobic metabolism was measured with ELISA. The analysis of oxidative stress was conducted with the water-soluble tetrazolium salt test.RESULTS The HIF-1α mRNA expression was the highest at 24 hours, whereas the HIF-2α mRNA showed no increased expression during the observation. The Cygb mRNA decreased after 24 hours. The highest expressions of HIF-1α and HIF-2α proteins were detected at 72 hours, whereas the Cygb protein expression increased since 24 hours. The PGC-1α protein expression increased at 72 hours. The WST test showed the highest ROS level at 24 hours.CONCLUSIONS The macrophages were activated by SRBCs underwent dual hypoxia and oxidative stress condition simultaneously to overcome the foreign bodies. The macrophages overcame these stress conditions by increasing their aerobic metabolism.
O corpo é a extensão da alma: um olhar foucaultiano sobre a disciplina moral da Igreja Apostólica (da Santa Vó Rosa) 1954-1970
Authors: Santos Pablo Henrique Costa 
Published: May 2019

A proposta da pesquisa é verificar os discursos doutrinários da igreja Apostólica (da Santa Vó Rosa) e identificar, neles, aspectos que induzem a um poder disciplinar que a instituição exerce através das suas regras morais. Elas funcionam como uma tentativa de controle do corpo frente às tentações pecaminosas que o mundo oferece no tempo do fim. Na doutrina da Igreja Apostólica, o corpo é entendido como a extensão da alma, por isso deve-se discipliná-lo para mantê-lo santificado. Acredita-se que, uma vez o corpo corrompido, logo a alma também o será. A padronização das vestes, dos gestos, dos comportamentos, a escolha da leitura e música adequada, do ambiente não pecaminoso, a ênfase nos males que os vícios e jogos podem proporcionar ao corpo e Ã alma, entre outros, são algumas normas disciplinares que compõem a forma como os apostólicos mantêm-se santos e diferenciados do "mundoâ€. Essas regras irradiam de um ponto central, que é a imagem, as meditações e testemunhos deixados pela Santa Vó Rosa, sendo ela uma espécie de figura escatológica, representante de Deus na terra e um exemplo de vida a ser imitado. As análises se darão a partir da perspectiva histórica crítica foucaultiana sobre a composição disciplinar apresentada pela instituição religiosa.
"Here begynnyth a schort tretys": disputas de poder e de gênero em The book of Margery Kempe (1436)
Authors: Barreiro Carolina Niedermeier 
Published: May 2019

A prática da escrita no período medieval era bastante restrita - aos clérigos, aos homens. No entanto, encontramos exceções Ã regra. Margery Kempe, por exemplo, foi uma mulher leiga que escreveu uma obra autobiográfica em meados do século XV. A partir de seu livro, The Book of Margery Kempe, tentaremos apontar algumas questões relativas aos estudos de gênero. Entendendo seu texto como um espaço possível para as disputas discursivas sobre gênero (suas relações e configurações), buscaremos apontar alguns indícios de como esses elementos aparecem em The Book. Destacaremos a partir deles os movimentos de aproximação ou de afastamento de Margery Kempe em relação às normativas de gênero comuns ao medievo.
RAPensando a formação docente: experiências e reflexões sobre o uso do RAP no ensino de história
Authors: Silva Roger Anibal Lambert da , Souto Bárbara Figueredo 
Published: May 2019

Nosso objetivo no presente artigo é apresentar algumas reflexões, atravésde relatos de experiências, sobre o uso do rap na sala de aula do EnsinoSuperior, ressaltando sua importância na formação dos futuros docentesda Educação Básica, sobretudo no que diz respeito a uma perspectivacrítica em relação Ã realidade social - fundamental, conforme sabemos,para o exercício tanto da docência quanto da cidadania.
Uma análise da função e estrutura dos textos consolatórios de Sêneca
Authors: Gomes Erick Messias Costa Otto 
Published: May 2019

Sêneca se valeu da epístola como suporte para escrever e divulgar suas consolatórias aos destinatários e outros leitores, haja vista a abordagem da condição específica do consolado e, ao mesmo tempo, a recomendação de conselhos filosóficos gerais em seus textos. Ademais, tais textos foram estruturados a partir de estratégias retóricas, as quais permitiriam, a partir de uma elaboração textual, comunicar a narrativa com uma função social. O uso da retórica na consolatio senequiana se fundamenta no uso de preceitos e exemplos e tem como objetivo persuadir o leitor-ouvinte Ã mudança, à prática da filosofia. Nesse artigo, iremos bordar esses dois pontos: a consolatória senequiana como epístola e a estrutura geral desses textos.
A Reforma do Ensino Médio - 2017: notas sobre a Formação de Professores, a Educação e a Educação Física /The High School Reform - 2017: notes on Teacher Training, Education and Physical Education
Authors: Soares Marta Genú , Abreu Meriane Conceição Paiva , Teixeira Carla Loyana Dias 
Published: May 2019

A reforma do ensino médio e a Lei 13.415, de 16 de fevereiro de 2017 são objeto de análise desse artigo que trata da repercussão na educação brasileira causada por imposição política, externa aos estudiosos e sujeitos da área, quanto ao ensino da educação física e às implicações para a formação de professores. Problematiza as características do campo da educação física expressas na lei e as implicações para a formação de professores. Metodologicamente, utiliza a abordagem dialética para a pesquisa bibliográfica e documental e faz a análise do discurso, como técnica de pesquisa. Conclui que a reforma configura a educação física uma prática, idealizando-se uma relação com a teoria; a lei admite o uso do documento Base Nacional Comum Curricular; prioriza o objeto de estudo na perspectiva da cultura corporal de movimento; valoriza o conhecimento do esporte e ginástica de condicionamento.
PALAVRAS-CHAVE: Ensino. Formação de Professores. Políticas Públicas
Caminhos à fertilidade intelectual. O curriculum trivium em contexto de rua / Pathways to intellectual fertility. The curriculum trivium in street context
Authors: Mesquita Mônica Maria Borges , De Vasconcelos Lia Maldonado Teles 
Published: May 2019

O Curriculum Trivium, desenvolvido por Ubiratan D'Ambrosio, propõe uma nova visão para os processos educativos enraizada na humanização dos espaços escolares. Neste artigo discute-se o processo do desenvolvimento deste currículo no seio de duas pequenas comunidades urbanas além mar, situadas na Costa de Caparica - Portugal. Ressalta-se as dinâmicas socioeconômicas e culturais locais emergentes, durante e após o desenvolvimento de um projeto educacional científico transdisciplinar e transcultural específico, e suas relações com este currículo. Esta trajetória é escolhida objetivando aguçar uma discussão fundamentada tanto em experiências de pesquisa em contextos de rua, quanto nas dinâmicas políticas (des)envolvidas em pesquisas construídas coletivamente. Conceitos como coragem (NIETSCHE, 1878/1996) e cegueira (SANTOS, 2001) são cerne nesta discussão, cujo objetivo central é contribuir para a humanização dos processos educativos em contexto de rua. A Teoria Social Crítica é evocada para suportar esta experiência de pesquisa educacional e, ao mesmo tempo, revela-se fundamental para evidenciar a postura etnomatemática construída. Os caminhos, aqui percorridos, delinearam uma "coisa diferenteâ€, no sentido adotado por Harvey (2012), mostrando que a transformação social, via o corpo uno educador-pesquisa, não só é possível como fundamental à definição de trajetórias revolucionárias. Esta "coisa diferente" (1) nasceu do encontro dos desejos, sentimentos, possibilidades, práticas e pensamentos de todos os membros envolvidos nas pesquisas e (2) veio para desvendar o como são construídos e reconstruídos os significados das relações cotidianas dos mesmos.
PALAVRAS-CHAVE: curriculum trivium; educação comunitária; educador etnomatemático; pesquisa bottom-up.
HAÇLI SEFERLERİNDE HAŞHAŞÎLER
Authors: AKIN Ahmet 
Published: May 2019

Bu yazımızda “Mana Yayınları” tarafından 2018’de yayınlanan Dr. Nadir Karakuş’a ait “Haçlı Seferlerinde Haşhaşîler” başlıklı kitabın tanıtımını yapmaya çalışacağız. Kitap yaklaşık 200 sahife ve dört bölümden oluşmaktadır. Suriye ve Filistin bölgesinde 1098’de Antakya’nın ele geçirilişinden 1291’de Akkâ Haçlı Krallığı’nın çöküşüne kadar olan sürede Haşhaşîlerin yaptıkları suikastlar, sığındıkları kaleler ve öğretilerinden bahsedilmektedir. On sekiz sayfalık “Giriş” bölümünde Nizarî İsmailîliğin ortaya çıkma süreci ve Hasan Sabbah’ın “ed-Da’vetü’l-Cedîde” adı altında yürüttüğü faaliyetlerin ortaya çıkışı ile başlayan anlatım, onun Fatımîler tarafından hakkı gasp edilen Nizar’ın haklarının hesabını sorma adı altında “Beldetü’l-İkbal” dediği Alamut Kalesi’nden yürüttüğü davet ele alınıyor.
Umweltfreundliche Verkehrsmittelwahl in der Urlaubsregion
Authors: Groß Sven , Grimm Bente 
Published: May 2019

Zusammenfassung
Seitens der verschiedensten Wissenschaftsdisziplinen wird sich mit der Verkehrsmittelwahl auseinandergesetzt. Im vorliegenden Beitrag werden ausgewählte Determinanten der Verkehrsmittelwahl im Tourismus analysiert. Dies wird erstmals anhand von repräsentativen Daten für den Urlaubsverkehr am Aufenthaltsort bei Haupturlaubsreisen der in Deutschland lebenden Bevölkerung durchgeführt. Ziel ist es, mehr über die Determinanten zu erfahren, die Einfluss auf die Verkehrsmittelwahl am Urlaubsort nehmen. Hiermit soll ein Beitrag hin zu einer nachhaltigen Mobilität von Urlaubern geschaffen werden. Daher wird im Folgenden der Schwerpunkt auf den öffentlichen Nahverkehr (ÖPNV) und das Fahrrad/E-Bike als Fortbewegungsmittel in der Urlaubsregion gelegt. Es können bei elf von 17 der einbezogenen Determinanten beim ÖPNV und bei 16 von 17 beim Fahrrad/E-Bike statistisch signifikante Unterschiede nachgewiesen werden. Es zeigt sich jedoch bei der Prüfung der Stärke des Zusammenhangs, dass bei den meisten Variablen nur eine geringfügige oder schwache Effektstärke feststellbar ist und die Effektstärken bei der ÖPNV- und der Fahrrad-/E-Bike-Nutzung (teilweise) voneinander abweichen. Während beim ÖPNV der Familienstand, das Verkehrsmittel bei der Anreise und – mit etwas Abstand – die Verfügbarkeit eines Pkw im Haushalt bei der Stärke des Zusammenhangs hervorstechen, gibt es bei der Radnutzung keine derart vorherrschenden Variablen. Es kristallisieren sich jedoch mehrere Variablen heraus, bei denen ein schwacher Zusammenhang nachweisbar ist, der ebenfalls beim ÖPNV beobachtet werden kann. Dies ist beim Alter, der derzeitigen Berufstätigkeit, der Haushaltsgröße, der Anzahl der Reiseteilnehmer und der Reiseart der Fall.
Specific Interactions Between Autosome and X Chromosomes Cause Hybrid Male Sterility in Caenorhabditis Species
Authors: Bi Yu , Ren Xiaoliang , Li Runsheng , Ding Qiutao , Xie Dongying , Zhao Zhongying 
Published: May 2019

Abstract
Hybrid male progeny from interspecies crosses are more prone to sterility or inviability than hybrid female progeny, and the male sterility and inviability often demonstrate parent-of-origin asymmetry. However, the underlying genetic mechanism of asymmetric sterility or inviability remains elusive. We previously established a genome-wide hybrid incompatibility (HI) landscape between Caenorhabditis briggsae and C. nigoni by phenotyping a large collection of C. nigoni strains each carrying a C. briggsae introgression. In this study, we systematically dissect the genetic mechanism of asymmetric sterility and inviability in both hybrid male and female progeny between the two species. Specifically, we performed reciprocal crosses between C. briggsae and different C. nigoni strains that each carry a GFP-labeled C. briggsae genomic fragment referred to as introgression, and scored the HI phenotypes in the F1 progeny. The aggregated introgressions cover 94.6% of the C. briggsae genome, including 100% of the X chromosome. Surprisingly, we observed that two C. briggsae X fragments that produce C. nigoni male sterility as an introgression rescued hybrid F1 sterility in males fathered by C. briggsae. Subsequent backcrossing analyses indicated that a specific interaction between the X-linked interaction and one autosome introgression is required to rescue the hybrid male sterility. In addition, we identified another two C. briggsae genomic intervals on chromosomes II and IV that can rescue the inviability, but not the sterility, of hybrid F1 males fathered by C. nigoni, suggesting the involvement of differential epistatic interactions in the asymmetric hybrid male fertility and inviability. Importantly, backcrossing of the rescued sterile males with C. nigoni led to the isolation of a 1.1-Mb genomic interval that specifically interacts with an X-linked introgression, which is essential for hybrid male fertility. We further identified three C. briggsae genomic intervals on chromosome I, II, and III that produced inviability in all F1 progeny, dependent on or independent of the parent-of-origin. Taken together, we identified multiple independent interacting loci that are responsible for asymmetric hybrid male and female sterility, and inviability, which lays a foundation for their molecular characterization.
DEVELOPING ISLAMIC SMART CITY MANAGEMENT USING ORGANISATION PUBLIC RELATIONSHIP (OPR) EFFECTIVENESS: A STRUCTURAL EQUATION MODELING (SEM) PARTIAL LEAST SQUARE APPROACH
Authors: Sentosa Ilham , Sinaga Obsatar , Zainal Zaimie , Mustika Djaya Arry Hutomo 
Published: May 2019

Purpose of Study: This study revaluates the interrelationships between relationship-building and bottom-line consequences to the public sector organisation and development of Islamic smart city management projects to confirmatory investigate the results of relationship measures on the internal customer satisfaction and behavioral intentions.
Methodology: In general, by connecting organisation-public relationship (OPRs) components and behavioral intentions outcomes may fortify and support the relationship marketing theory. The previous result of the linear regression analysis supports the proposed model based on the empirically validated organisation-public relationship (OPRs) components, which were reliable and valid.
Main Findings: The results of reliability, correlation, regression analysis, and Mahalanobis Distance analysis using PLS technique data analysis were presented. Outcomes from structural equation modeling show that customer satisfaction mediated the connection between organisation-public relationship (OPRs) dimensions and behavioral intentions consequences. In the same meaning, customer satisfaction is a predictor and exogenous variable in the model. The results revealed that public sector managers perceived the development of Islamic smart city management within the public sector organisation as trustworthy would more likely to say positive things of the current organisation.
PRELIMINARY ANALYSIS ON RELATIONSHIP OF CRM FUNCTIONS IMPLEMENTATION TOWARDS FIRM’S BUSINESS PERFORMANCE
Authors: Farid Shamsudin Mohd , Fikri Ishak Mohd , Asyraf Hashim Muhammad , Abdel Nabi Milad , Mohamad Yazid Mohd Faizun , Abdul Razak Anis 
Published: May 2019

Purpose of Study: The purpose of this preliminary study is to determine the reliability and validity of the instrument used and feasible for full-scale analysis of the aforementioned studied phenomenon. PLS-SEM is employed in this preliminary study that utilised SmartPLS 3.0. Methodology: Drawing on RBV (resource-based view) the implementation of customer relationship management (CRM) functions in hotel industry had become a central strategy in determining competitive advantage. Empirical studies had documented that small and medium hotels had also embraced on customer-centric business practice that endures CRM functions as their strategy in sustaining competitive advantage. Indeed, they inclines to implement elementary CRM functions that leverage the IBT’s (internet-based technologies) of hotel website. CRM functions is regarded as firms’ resource that effectively deployed may lead to competitive advantage that portray in positive business performance. A total of seventy-five respondents (managers and owners) of small and medium hotels managers and owners from Greater Kuala Lumpur participated in the survey realised through convenient sampling method. Main Findings: The result of PLS-SEM analysis on measurement model had showed a robust analysis of internal reliability and validity. Assessment of items and constructs included in the study exhibits a good internal consistency and valid, thus, reflects an acceptable research model that are feasible and ready a full-scale analysis.
THE RELATIONSHIP BETWEEN ENTREPRENEURSHIP EDUCATION AND ENTREPRENEURIAL INTENTION OF UNIVERSITI KUALA LUMPUR – TEKNOPUTRA ALUMNI
Authors: Abdul Rani Nazatul Shima , Sarojani Krishnan K. , Saidun Zulkifli , Ahmad Haniza 
Published: May 2019

Purpose: The unemployment rate among graduates is considered high in Malaysia despite concerted efforts taken by the Malaysian government in resolving the issue. If this issue is not tackled immediately by the government, the unemployment rate may soar and hence lead to social problems in the country. The aim of this study is to explore the relationship between entrepreneurship education and entrepreneurial intention of Universiti Kuala Lumpur TEKNOPUTRA Alumni. Methodology: An online survey was conducted to explore if there is a relationship between entrepreneurship education the graduates had received at the university and their entrepreneurial intention to become entrepreneurs. About 50 graduates responded to the survey and they consisted of male and female graduates most of who were aged between 20 and 25 with less than 2 years of working experience. The sample had ventured into service types of business while others were sole proprietors, and most of them have been involved in their business for less than 5 years. Results: Cronbach Alpha values for the reliability analysis of items for entrepreneurship education (α=0.953) and entrepreneurial intention (α=0.893) show that the items are reliable. Inferential statistics, that is Pearson r correlation was run to determine the relationship between the independent variable, entrepreneurship education and the dependent variable entrepreneurship intention. Implications: Pearson Correlation analysis shows that there is a positive and significant relationship between entrepreneurship educations with entrepreneurial intention among TEKNOPUTRA Alumni. In short, this implies that most of the TEKNOPUTRA Alumni agreed that entrepreneurship education they had received at the university has influenced their entrepreneurial intention to become entrepreneurs.
Possible predictive markers to make a decision for surgical intervention in discography
Authors: OGDEN Mustafa , YÜKSEL Ulaş , AKKAYA Süleyman , BULUT İbrahim Umut , BAKAR Bülent , ÖZVEREN Mehmet Faik 
Published: May 2019

Aim:
In this retrospective study, the diagnostic and therapeutic events of
discography and disc-blockage (discoblock) were investigated in patients whose
clinical symptoms could not be explained by CT and/or MR images.Material
and Methods: The study included patients applied
with discography between August 2014 and October 2016. Patient data were recorded, consisting of age,
gender, pre-procedure Visual Analogue Scale (VAS) score (PRE-VAS),
post-procedure VAS score (POST-VAS), and pre-procedure “Japanese Orthopedic Association” (JOA) score (PRE-JOA),
post-procedure JOA score (POST-JOA), long-term follow-up VAS score (FOLLOW-VAS)
and JOA score (FOLLOW-JOA), level of herniated disc in the spinal column (L1-2,
L2-3, L3-4, L4-5, L5-S1), size of herniated disc ("bulging",
"protrusion", "extrusion") and localization of the herniated
disc in the spinal canal (median or foraminal).Results:
Evaluation was made of a total of 22 patients (11 females, 11 males) aged 32 - 60
years. Discectomy after discography and/or discoblock was applied to 12 patients.
The PRE-VAS scores of patients who underwent discectomy were higher than those
of patients who did not undergo surgery, and the scores were lower in the
postoperative period than those of the unoperated group. The long term (6
months) follow-up results indicated that patients with discectomy and those
without surgery had similar levels of pain. The JOA scores of patients with
discectomy were higher than those of patients without surgery.

Conclusion:
At
the end of this study, it was thought that discography and discoblock procedure
could be an adjunctive test for decision-making in respect of surgery for
patients who were not diagnosed using radiological views and clinical symptoms.
Furthermore, it was considered that the VAS score applied before and after
discography may identify the patients who will be applied with discectomy.
Understanding Response Patterns Among Healthcare Professionals Regarding Their Attitudes Toward Working With Sexual Health—Latent Class Analysis of the SA-SH
Authors: Areskoug-Josefsson Kristina , Rolander Bo 
Published: May 2019

Background and PurposeStudents in healthcare professions need to be comfortable and prepared to handle sexual health issues in their future professional role. The aim was to explore and classify response patterns of the Student's Attitudes toward Addressing Sexual Health scale (SA-SH), to increase the pragmatic usefulness of the questionnaire.MethodsResponse patterns of the SA-SH were explored with latent class analysis (LCA). The response patterns were analyzed for relevant levels of total scale scores for each class.ResultsThe total score of the SA-SH can be translated into three response patterns, enabling quick and valid calculations of students' perceived level of comfort and preparedness to address sexual health issues in their future profession.ConclusionsThe SA-SH is useful for measuring nursing students' level of comfort and preparedness to address sexual health.