bluuebunny/crossref_metadata_2025_split huggingface dataset:
The significant influence of having children on the postoperative prognosis of patients with nonsmall cell lung cancer: A propensity score‐matched analysis
Authors: Takamori Shinkichi , Tagawa Tetsuzo , Toyokawa Gouji , Ueo Hiroki , Shimokawa Mototsugu , Kinoshita Fumihiko , Matsubara Taichi , Kozuma Yuka , Haratake Naoki , Akamine Takaki , Katsura Masakazu , Takada Kazuki , Hirai Fumihiko , Shoji Fumihiro , Okamoto Tatsuro , Oda Yoshinao , Maehara Yoshihiko 
Published: May 2018

AbstractThe aim of this study was to elucidate the relationship between family‐associated factors and the postoperative prognosis in patients with nonsmall cell lung cancer (NSCLC). Additionally, we investigated whether having children was associated with the postoperative maintenance of the nutritional status. We selected 438 NSCLC patients who had undergone curative lung resection between 2004 and 2011 at Kyushu University (Fukuoka, Japan), whose family‐associated factors were available. Nutritional indices, including the prognostic nutritional index (PNI), were used to estimate the change in the nutritional status for 1 year after surgery. A propensity score analysis was conducted after adjusting the following variables: sex, age, smoking history, performance status, pathological stage, and histological type. Three hundred patients (68.5%) had both children and partners. Forty‐nine patients (11.2%) only had children, and 56 (12.8%) patients only had a partner. Thirty‐three patients (7.5%) did not have a partner or children. The overall survival (OS) and disease‐free survival (DFS) of the partner‐present and partner‐absent patients did not differ to a statistically significant extent (P = .862 and P = .712, respectively). However, childless patients showed significantly shorter OS and DFS in comparison with patients with children (P = .005 and P = .002, respectively). The postoperative exacerbation of PNI was significantly greater in childless patients than in patients with children (P = .003). These results remained after propensity score matching. Childless patients had a significantly poorer postoperative prognosis than those with children. Surgeons caring for childless NSCLC patients should be aware of the poorer postoperative outcomes in this population.
Prevention of cisplatin‐induced hearing loss in children: Informing the design of future clinical trials
Authors: Minasian Lori M. , Frazier A. Lindsay , Sung Lillian , O’Mara Ann , Kelaghan Joseph , Chang Kay W. , Krailo Mark , Pollock Brad H. , Reaman Gregory , Freyer David R. 
Published: May 2018

AbstractCisplatin is an essential chemotherapeutic agent in the treatment of many pediatric cancers. Unfortunately, cisplatin‐induced hearing loss (CIHL) is a common, clinically significant side effect with life‐long ramifications, particularly for young children. ACCL05C1 and ACCL0431 are two recently completed Children’s Oncology Group studies focused on the measurement and prevention of CIHL. The purpose of this paper was to gain insights from ACCL05C1 and ACCL0431, the first published cooperative group studies dedicated solely to CIHL, to inform the design of future pediatric otoprotection trials. Use of otoprotective agents is an attractive strategy for preventing CIHL, but their successful development must overcome a unique constellation of methodological challenges related to translating preclinical research into clinical trials that are feasible, evaluate practical interventions, and limit risk. Issues particularly important for children include use of appropriate methods for hearing assessment and CIHL severity grading, and use of trial designs that are well‐informed by preclinical models and suitable for relatively small sample sizes. Increasing interest has made available new funding opportunities for expanding this urgently needed research.
Preliminary experience with a novel Multisensor algorithm for heart failure monitoring: The HeartLogic index
Authors: Santini Luca , Mahfouz Karim , Schirripa Valentina , Danisi Nicola , Leone Michelangelo , Mangone Gloria , Campari Monica , Valsecchi Sergio , Ammirati Fabrizio 
Published: May 2018

Key Clinical MessageWe report the first case of a patient in whom an implantable cardioverter‐defibrillator (ICD) endowed with HeartLogic, a novel algorithm for heart failure (HF) monitoring, was implanted in clinical practice. The good temporal association between HeartLogic index threshold crossings and HF hospitalizations confirms the high sensitivity in detecting gradual worsening of HF.
Is black tar heroin use associated with wound botulism? A report of two Hispanic patients
Authors: Qureshi Ihtesham A. , Qureshi Mohtashim A. , Vellipuram Anantha‐Ramana , Kassar Darine 
Published: May 2018

Key Clinical MessageWound botulism is a potentially lethal condition that can cause paralysis. Its association with black tar heroin is a well‐established fact. It is essential to alert clinicians in recognizing the patients with history of injection drug abuse presenting with clinical features of botulism early on admission for prompt diagnosis and treatment.
Coupling of Epoxides and Lactones by Cationic Indium Catalysts To Form Functionalized Spiro‐Orthoesters
Authors: Jung Hyuk‐Joon , Chang Chen , Yu Insun , Aluthge Dinesh C. , Ebrahimi Tannaz , Mehrkhodavandi Parisa 
Published: May 2018

AbstractWe prepared a cationic indium catalyst for the conversion of epoxides and lactones into spiro‐orthoesters (SOEs), a family of expanding monomers. The cationic indium alkyl complexes [(NNiO)In(CH2SiMe3)(S)][B{3,5‐(CF3)2C6H3}4] (2⋅Solv; H(NNiO)=2,4‐dicumyl‐6‐({[2‐(dimethylamino)cyclohexyl]imino}methyl)phenol, S=OEt2 or THF) were synthesized and fully characterized. The reaction of ϵ‐caprolactone with 1,2‐epoxy‐7‐octene resulted in the formation of 2‐(hex‐5‐en‐1‐yl)‐1,4,6‐trioxaspiro[4.6]undecane (SOE1) with full conversion of both components. We extended the substrate scope to five‐ and six‐membered lactones as well as to a number of functionalized epoxides. The reactivity of the SOEs was explored.
Asymmetric Supercapacitor Based on Chemically Coupled Hybrid Material of Fe2O3‐Fe3O4 Heterostructure and Nitrogen‐Doped Reduced Graphene Oxide
Authors: Mallick Sourav , Jana Partha Pratim , Raj C. Retna 
Published: May 2018

AbstractThe synthesis of a novel chemically coupled hybrid material based on Fe2O3‐Fe3O4 heterostructure and nitrogen‐doped reduced graphene oxide (N‐rGO) for the development of high performance supercapacitor devices is demonstrated. The chemically coupled hybrid material is synthesized in a one‐pot method under hydrothermal condition, resulting in the formation of crystalline α‐Fe2O3 and poorly crystalline/amorphous Fe3O4. The Fe2O3‐Fe3O4 particles have an average size of 30–50 nm. Chemical integration of Fe2O3‐Fe3O4 with N‐rGO through Fe‐O−C bonds is achieved. The chemical coupling of N‐rGO with pseudocapacitive Fe2O3‐Fe3O4 enhances the overall performance of the composite. Two asymmetric supercapacitor devices using the hybrid material either as positive or negative electrode are fabricated. The supercapacitive behaviour is evaluated in terms of specific capacitance, energy density, power density and cycling stability, showing excellent performance. The asymmetric device based on hybrid material as the positive and activated carbon as the negative electrode, delivers a specific capacitance of 111.95 F g−1 at 0.8 A g−1 with an energy density of 44.93 Wh kg−1. The supercapacitor has excellent cycling stability with a capacitance retention of >92 % even after 10000 extensive charge‐discharge cycles. The all‐solid‐state asymmetric supercapacitor device is fabricated using gel electrolyte. Solid‐state devices connected in series successfully light up 29 LEDs.
Simple Microwave‐Assisted Synthesis of Delafossite CuFeO2 as an Anode Material for Sodium‐Ion Batteries
Authors: Youn Duck Hyun , Choi Yo Han , Kim Jun‐Hyuk , Han Sungmin , Heller Adam , Mullins C. Buddie 
Published: May 2018

AbstractA simple synthesis of microcrystalline delafossite CuFeO2 is reported. Rhombohedral CuFeO2 0.7–2.5 μm crystals were obtained by heating an aqueous solution of Fe(NO3)3, Cu(NO3)2, and propionaldehyde to 180 °C for 2 h in a microwave oven, which enables the synthesis of the CuFeO2 microcrystals with significantly reduced heating time at a mild temperature. The electrode made with the delafossite CuFeO2 discharged at 0.01 V and charged at 1.5 V vs Na+/Na and retained a reversible capacity of 240 mAh g−1 at a specific current of 0.1 Ag−1 after 200 cycles. The delafossite CuFeO2 microcrystals could be a potential anode material for sodium‐ion batteries considering the simple synthetic method and acceptable reversible capacity compared to other nanostructured anode materials.
Donor–Donor′–Acceptor Triads Based on [3.3]Paracyclophane with a 1,4‐Dithiafulvene Donor and a Cyanomethylene Acceptor: Synthesis, Structure, and Electrochemical and Photophysical Properties
Authors: Sako Katsuya , Hasegawa Tomoya , Onda Hiroyuki , Shiotsuka Michito , Watanabe Motonori , Shinmyozu Teruo , Tojo Sachiko , Fujitsuka Mamoru , Majima Tetsuro , Hirao Yasukazu , Kubo Takashi , Iwanaga Tetsuo , Toyota Shinji , Takemura Hiroyuki 
Published: May 2018

AbstractDonor–donor′–acceptor triads (1, 2), based on [3.3]paracyclophane ([3.3]PCP) as a bridge, with electron‐donating properties (D′) using 1,4‐dithiafulvene (DTF; TTF half unit) as a donor and dicyanomethylene (DCM; TCNE half unit) or an ethoxycarbonyl‐cyanomethylene (ECM) as an acceptor were designed and synthesized. The pulse radiolysis study of 1 a in 1,2‐dichloroethane allowed the clear assignment of the absorption bands of the DTF radical cation (1 a.+), whereas the absorption bands due to the DCM radical anion could not be observed by γ‐ray radiolysis in 2‐methyltetrahydrofuran rigid glass at 77 K. Electrochemical oxidation of 1 a first generates the DTF radical cation (1 a.+), the absorption bands of which are in agreement with those observed by a pulse radiolysis study, followed by dication (1 a2+). The ESR spectrum of 1 a.+ showed a symmetrical signal with fine structure and an ESR simulation predicted that the spin of 1 a.+ is delocalized over S and C atoms of the DTF moiety and the central C atom of the trimethylene bridge bearing the DTF moiety. Pulse radiolysis, ESR, and electrochemical studies indicate that the DTF radical cation of 1 a.+ is more stable than that of 6.+, and the latter shows a strong tendency to dimerize. This result indicates that the [3.3]PCP moiety as a bridge can stabilize the DTF radical cation more than the 1,3‐diphenylpropane moiety because of kinetic stability due to its rigid structure and the weak electronic interaction of DTF and DCM moieties through [3.3]PCP.
Progress, Mechanisms and Applications of Liquid‐Metal Catalyst Systems
Authors: Liang Shu‐Ting , Wang Hong‐Zhang , Liu Jing 
Published: May 2018

AbstractAmong the significant growths of liquid metal (LM) research achieved over the past few years, the field of LM as catalysts offers promising opportunities for material scientists to exploit, and thus, burgeoning progress has been made. This article presents an overview of recent progress in developing LM catalysis, which spans from liquid‐phase catalysts, photocatalysts, heterogeneous catalysts, and bimetallic catalysts, to catalysts based on liquid‐metal/metal‐oxide (LM/MO) frameworks. The different types, preparation methods, and typical applications of LM catalysts are classified and reviewed. Typical catalytic applications of LM systems discussed include the growth of graphene films/nanoribbons/carbon nanotube, photocatalytic degradation of CR or PFOA/splitting of H2O/reduction of CO2, and catalytic reactions like butane or acetylene dehydrogenation, methanol steam reforming, and reduction of potassium ferricyanide. The prospects, future trends, and challenges of LM catalysts are also mentioned.
Discrete Triptycene‐Based Hexakis(metalsalphens): Extrinsic Soluble Porous Molecules of Isostructural Constitution
Authors: Reinhard Dennis , Zhang Wen‐Shan , Rominger Frank , Curticean Ronald , Wacker Irene , Schröder Rasmus R. , Mastalerz Michael 
Published: May 2018

AbstractIn 2013 the concept of OMIMs (organic molecules of intrinsic microporosity) was introduced by McKeown et al. These OMIMs are constructed on the basis of rigid molecular cores such as triptycene, spirobifluorenes, and others. Like shape‐persistent organic cages, these are soluble discrete molecules and therefore an interesting alternative to 3D, insoluble porous materials, such as metal–organic frameworks, covalent‐organic frameworks, or zeolites. OMIMs are chemically and thermally robust because the formation of strong covalent bonds has been used for their synthesis. To date, a few OMIMs have been reported, though most of them did not contain any functional unit to enhance gas sorption properties. This work introduces an isostructural series of metal–salphene based OMIMs with different metal ions (Zn2+, Ni2+, Cu2+, Pd2+, and Pt2+) integrated into the backbone. The influence of the metal centers on interaction with gas molecules has been investigated by gas sorption experiments.
Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS‐derived Pyrans
Authors: Guo Huijuan , Benndorf René , König Stefanie , Leichnitz Daniel , Weigel Christiane , Peschel Gundela , Berthel Patrick , Kaiser Marcel , Steinbeck Christoph , Werz Oliver , Poulsen Michael , Beemelmanns Christine 
Published: May 2018

AbstractWe characterized two key biosynthetic intermediates of the intriguing rubterolone family (tropolone alkaloids) that contain a highly reactive pyran moiety (in equilibrium with the hydrolyzed 1,5‐dione form) and undergo spontaneous pyridine formation in the presence of primary amines. We exploited the intrinsic reactivity of the pyran moiety and isolated several new rubterolone derivatives, two of which contain a unique thiazolidine moiety. Three rubterolone derivatives were chemically modified with fluorescence and biotin tags using peptide coupling and click reaction. Overall, eight derivatives were fully characterized by HRMS/MS and 1D and 2D NMR spectroscopy and their antimicrobial, cytotoxic, anti‐inflammatory and antiparasitic activities evaluated.
Thermally Stable Gold(III) Alkene and Alkyne Complexes: Synthesis, Structures, and Assessment of the trans‐Influence on Gold–Ligand Bond Enthalpies
Authors: Chambrier Isabelle , Rocchigiani Luca , Hughes David L. , Budzelaar Peter M. H. , Bochmann Manfred 
Published: May 2018

AbstractThe reaction of [C^C)Au(OEt2)2]+ with 1,5‐cyclooctadiene or norbornadiene affords the corresponding olefin complexes [(C^C)Au(COD)]SbF6 and [(C^C)Au(NBD)]SbF6, which are thermally stable in solution and the solid state (C^C=4,4′‐di‐tert‐butylbiphenyl‐2,2′‐diyl). The crystal structures of these complexes have been determined. By contrast, dienones such as dibenzylideneacetone are O‐ rather than C=C‐bonded. The reactions of (C^C)Au(OAcF)(L) (L=PMe3 or CNxyl) with B(C6F5)3 in the presence of bis(1‐adamantyl)acetylene give the mixed‐ligand alkyne complexes [(C^C)Au(AdC≡CAd)(L)]+, the first complexes of their type in gold chemistry. In the presence of an excess of acetylene these compounds are thermally stable in solution and as solids. The bonding of n‐ and π‐donor ligands to AuIII fragments and the effect of the trans influence exerted by N‐ and C‐donors was explored with the aid of DFT calculations. Results show that the Au−L bond enthalpies trans to anionic C are 35–60 % of the enthalpies trans to N, with strong π‐acceptors being particularly affected. In comparison with [Me2Au]+, the [(C^C)Au]+ fragment is more polar and in bond enthalpy terms resembles Me2Pt.
Formation of a peri‐Bridged Phosphonio‐Naphthalene by Cu‐Mediated Phosphine–Aryl Coupling
Authors: Blons Charlie , Duval Maryne , Delcroix Damien , Olivier‐Bourbigou Hélène , Mallet‐Ladeira Sonia , Sosa Carrizo E. Daiann , Miqueu Karinne , Amgoune Abderrahmane , Bourissou Didier 
Published: May 2018

AbstractThe peri‐iodo naphthyl phosphine 1 reacts with CuI to give the peri‐bridged phosphonio‐naphthalene 2, which has been fully characterized (multi‐nuclear NMR, MS, XRD). The outcome of the reaction differs markedly from that observed with gold. A two‐step pathway involving P‐assisted C−I oxidative addition to copper, followed by P−C reductive elimination is shown to be energetically feasible by DFT calculations.
Tuning the Activity of Heterogeneous Cofacial Cobalt Porphyrins for Oxygen Reduction Electrocatalysis through Self‐Assembly
Authors: Oldacre Amanda N. , Crawley Matthew R. , Friedman Alan E. , Cook Timothy R. 
Published: May 2018

AbstractWe report a suite of coordination‐driven self‐assembled prisms for heterogeneous electrocatalytic oxygen reduction (ORR) differing in the molecular clips linking two porphyrin faces in a cofacial arrangement. ORR activities and selectivities of monomeric CoTPyP along with cofacial prisms Ox‐Co, Oxa‐Co, and Benzo‐Co were probed using cyclic voltammetry and rotating ring‐disk techniques. All species were immobilized as heterogeneous catalysts on glassy carbon electrodes using a Nafion ink method. The selectivities of Ox‐Co, Oxa‐Co, and Benzo‐Co prisms towards H2O as determined by RRDE were 87, 97, and 75 %, respectively. The current density of the Oxa‐Co plateaus at five times that of Pt/C when normalized per Co/Pt. The high synthetic yield (79 %), competitive overpotential (η ≈800 mV) and high selectivity (%H2O ≈97 %) of the Oxa‐Co highlights how self‐assembly can be used to address multi‐electron multi‐proton transformations using polynuclear catalysts.
End‐Capping π‐Conjugated Systems with Medium‐Sized Sulfur‐Containing Rings: A Route Towards Solution‐Processable Air‐Stable Semiconductors
Authors: Fukazawa Aiko , Toda Yusuke , Hayakawa Masahiro , Sekioka Anna , Ishii Hiroyuki , Okamoto Toshihiro , Takeya Jun , Hijikata Yuh , Yamaguchi Shigehiro 
Published: May 2018

AbstractThe sulfur‐containing nine‐membered heterocycle thiacyclononene (TN) was evaluated as a new type of end‐capping group for π‐conjugated systems. A systematic study on TN‐capped α‐oligothiophenes (TNnTs; n=4–7) revealed that the capping with TN, which adopts a bent conformation, imparts the resulting oligothiophenes with drastically increased solubility at approximately 140 °C and high electrochemical stability, whereas the electronic structure remains virtually unperturbed. The even‐numbered oligothiophenes TN4T and TN6T form characteristic offset herringbone‐type packing structures on account of the steric repulsion between the TN rings and the presence of intermolecular nonbonding S⋅⋅⋅S interactions. This packing mode in combination with the high solubility enabled the solution‐process fabrication of field‐effect transistors based on TN6T, which exhibited a high performance without degradation even upon exposure to air.
Modelling diffusion of fragrances: A radial perspective
Authors: Pereira Joana , Costa Patrícia , Loureiro José Miguel , Rodrigues Alírio E. 
Published: May 2018

AbstractIn the present study, a theoretical model based on Fick's second law for radial diffusion is proposed for modelling the radial diffusion of fragrances. For that, three fragrance systems were studied containing α‐pinene and limonene as pure components, or a mixture of α‐pinene, limonene, linalool, and geranyl acetate. This model combines the UNIFAC group contribution method for the vapour‐liquid equilibrium with the Fickian radial diffusion model. The experimental gas concentrations of the odorant components were measured in a diffusion tube (1D axial diffusion) and quantified using gas chromatography with a flame ionization detector. The numerical solutions were obtained using the general Process Modelling Systems (gPROMS) software version 4.2.0. An equivalence relation between the 1D axial diffusion model and 1D radial diffusion model was developed. Finally, the odour intensity and character of the studied fragrance systems were assessed using Stevens’ power law and the strongest component model, respectively. The obtained results showed good agreement between the numerical simulation and the experimental gas concentration data, suggesting the proposed methodology as an efficient tool to assess the radial diffusion of fragrance systems over time and distance.
The impact of the rising colorectal cancer incidence in young adults on the optimal age to start screening: Microsimulation analysis I to inform the American Cancer Society colorectal cancer screening guideline
Authors: Peterse Elisabeth F. P. , Meester Reinier G. S. , Siegel Rebecca L. , Chen Jennifer C. , Dwyer Andrea , Ahnen Dennis J. , Smith Robert A. , Zauber Ann G. , Lansdorp‐Vogelaar Iris 
Published: May 2018

BACKGROUNDIn 2016, the Microsimulation Screening Analysis‐Colon (MISCAN‐Colon) model was used to inform the US Preventive Services Task Force colorectal cancer (CRC) screening guidelines. In this study, 1 of 2 microsimulation analyses to inform the update of the American Cancer Society CRC screening guideline, the authors re‐evaluated the optimal screening strategies in light of the increase in CRC diagnosed in young adults.METHODSThe authors adjusted the MISCAN‐Colon model to reflect the higher CRC incidence in young adults, who were assumed to carry forward escalated disease risk as they age. Life‐years gained (LYG; benefit), the number of colonoscopies (COL; burden) and the ratios of incremental burden to benefit (efficiency ratio [ER] = ΔCOL/ΔLYG) were projected for different screening strategies. Strategies differed with respect to test modality, ages to start (40 years, 45 years, and 50 years) and ages to stop (75 years, 80 years, and 85 years) screening, and screening intervals (depending on screening modality). The authors then determined the model‐recommended strategies in a similar way as was done for the US Preventive Services Task Force, using ER thresholds in accordance with the previously accepted ER of 39.RESULTSBecause of the higher CRC incidence, model‐predicted LYG from screening increased compared with the previous analyses. Consequently, the balance of burden to benefit of screening improved and now 10‐yearly colonoscopy screening starting at age 45 years resulted in an ER of 32. Other recommended strategies included fecal immunochemical testing annually, flexible sigmoidoscopy screening every 5 years, and computed tomographic colonography every 5 years.CONCLUSIONSThis decision‐analysis suggests that in light of the increase in CRC incidence among young adults, screening may be offered earlier than has previously been recommended. Cancer 2018;124:2964‐73. © 2018 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.
Nanosized‐Zinc‐Mediated Self‐Gelation of Graphene Oxide under Ambient Conditions
Authors: Lin Yunhui , Boyer Cyrille , Zhu Shenmin , Wang Da‐Wei 
Published: May 2018

AbstractSelf‐assembly of 3D reduced graphene oxide (rGO) sponges has received increasing attention in recent years. By far, chemical reduction, hydrothermal treatment, template‐directed chemical vapor deposition, and electrodeposition are the typical methods. Herein, the utilization of zinc nanoparticles as a reducing agent to fabricate 3D rGO sponges is reported. The relative negative standard electrode potential of zinc to graphene oxide (GO) allowed the spontaneous formation of the rGO−Zn hydrogel. Zinc‐free 3D rGO sponges were recovered by acid leaching of the zinc species and freeze‐drying. This room‐temperature electroless gelation is dependent on pH. The structure and electrochemical performance of the as‐synthesized rGO sponges were determined by the mass ratio of Zn to GO. Comprehensive physical and chemical characterizations were utilized to understand the 3D structure evolution of the rGO sponges. The rGO sponge, with an optimized texture, showed high capacitance and good stability in 1 m H2SO4 electrolyte.