bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorinated polyacrylates containing amino side chains for the surface modification of waterborne epoxy resin
Authors: He Sha , Liu Weiqu , Yang Maiping , Liu Chunhua , Jiang Chi , Wang Zhengfang 
Published: September 2018

ABSTRACTFluorinated polyacrylates containing amino side chains (FACAs) were synthesized to improve the water repellency of waterborne epoxy resin. First, FACA was prepared by a two‐step process. Then, a phase‐inversion emulsion technique, taking FACA as the reactive surface additives, was employed to prepare waterborne epoxy resin. The effect of the fluorinated content and the length of the fluorine side chain on the surface, thermal, and bulk properties of the waterborne epoxy resin were investigated. It was observed that moderate increase of the fluorinated content or the length of the fluorine side chain improved the contact angle and thermal properties while the mechanical property was not deteriorated. A small amount of fluoride (0.07 wt %) in the EA‐F1/3‐1 sample can dramatically increase the water contact angle from 72.63° to 95.31° due to the strong tendency of the macromonomers to migrate toward the outmost layer, resulting in enrichment of fluorine atoms on the surface. X‐ray photoelectron spectroscopy results revealed that for a given weight of the two macromonomers, F atomic concentration of the copolymer modified by longer fluorinated side chains was higher than that modified by short fluorinated side chains. From the present investigation, FACA successfully improved the surface property of waterborne epoxy resin and showed a prominent potential application in large‐scale industrialization. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47091.
Effects of coupling agents on the properties of an NR/SBR matrix and its adhesion to continuous basalt fiber cords
Authors: Li Zhuo , Wan Jijun , Li Yingzhe , Li Yang , Zhao Fei , Zhao Shugao 
Published: September 2018

ABSTRACTThe effects of various coupling agents on the characteristics and properties of a natural rubber (NR)/styrene–butadiene rubber (SBR) matrix and its adhesion to continuous basalt fiber (CBF) cords were studied. Four types of silane‐based and two types of titanate‐based coupling agents were added separately to the rubber matrix during the mixing process. The processability of the rubber compounds and the mechanical and tension fatigue properties of the vulcanizates were evaluated. The static and dynamic adhesion between the CBF cord/rubber matrices were investigated using the H pull‐out test and an elastomer testing system, respectively. The results showed that the effects of the coupling agent were controlled by its chemical structure, and it was found that the addition of (3‐aminopropyl)triethoxysilane was the most effective for enhancing the interfacial fatigue properties, due to the combined improvements of the initial adhesion, interfacial stress states, and the fatigue property of the rubber matrix. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019,136, 47098.
Resonance Rayleigh scattering assay for EGFR using antibody immobilized gold nanoparticles
Authors: Li Junbo , Yang Yanqiang , Zhang Xinxin , Zhang Bing , Chang Honghong , Wei Wenlong 
Published: September 2018

AbstractA highly selectivity determination of epidermal growth factor receptor (EGFR) has been described in the article. Antibody immobilized cysteamine (Cys) functionalized gold nanoparticles (AuNP) were proposed as immunosensors, and resonance Rayleigh scattering (RRS) was used for detection. First, Cys stabilized AuNPs (Cys‐AuNP) were prepared by the reduction of chloroauric acid with sodium borohydride in the presence of Cys. Further, anti‐EGFR antibody (Cetuximab, C225) was covalently linked to the Cys‐AuNP by carbodiimide‐mediated amidation protocol to yield the C225‐AuNP immunoprobe. The prepared conjugations were characterized by ultraviolet‐visible (UV‐vis) spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared (FT‐IR) and sodium dodecyl sulphate‐polyacrylamide gel electrophoresis (SDS‐PAGE). Based on the specific binding of C225 to EGFR, an RRS method was established to determine the concentration of EGFR. Under the optimal conditions, the concentration of EGFR was related to the intensity of RRS in the range 30–130 ng ml−1 with a low detection limit of 4.0 ng ml−1. Meanwhile, the proposed immunosensor exhibited excellent selectivity and anti‐interference property. The method was applied to the determination of EGFR in human serum and cancer cell lysate samples with satisfactory results.
Repetitive transcranial magnetic stimulation therapy for motor recovery in Parkinson's disease: A Meta‐analysis
Authors: Yang Changxia , Guo Zhiwei , Peng Haitao , Xing Guoqiang , Chen Huaping , McClure Morgan A. , He Bin , He Lin , Du Fei , Xiong Liangwen , Mu Qiwen 
Published: September 2018

AbstractIntroductionTherapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on motor recovery of Parkinson's disease (PD) have been reported; however, the protocols of these studies varied greatly. The aim of this meta‐analysis was to evaluate the optimal rTMS parameters for motor recovery of PD.MethodsElectronic databases were searched for studies investigating the therapeutic effects of rTMS on motor function in patients with PD. The section III of the Unified Parkinson's Disease Rating Scale (UPDRS) was extracted as the primary outcome, and the standardized mean difference (SMD) with 95% confidence interval (CI) was calculated.ResultsTwenty‐three studies with a total of 646 participants were included. The pooled estimates of rTMS revealed significant short‐term (SMD, 0.37; p < 0.00001) and long‐term (SMD, 0.39; p = 0.005) effects on motor function improvement of PD. Subgroup analysis observed that high‐frequency rTMS (HF‐rTMS) was significant in improving motor function (SMD, 0.48; p < 0.00001), but low‐frequency rTMS (LF‐rTMS) was not. In particular, when HF‐rTMS targeted over the primary motor cortex (M1), in which the bilateral M1 revealed a larger effect size than unilateral M1. Compared to single‐session, multi‐session of HF‐rTMS over the M1 showed significant effect size. In addition, HF‐rTMS over the M1 with a total of 18,000–20,000 stimulation pulses yielded more significant effects (SMD, 0.97; p = 0.01) than other dosages.ConclusionsIn conclusion, multi‐session of HF‐rTMS over the M1 (especially bilateral M1) with a total of 18,000–20,000 pulses appears to be the optimal parameters for motor improvement of PD.
Application of Scilab/Xcos for process control applied to chemical engineering educational projects
Authors: Vieira Eros B. , Busch Wesley F. , Prata Diego M. , Santos Lizandro S. 
Published: September 2018

AbstractThe study of process control applied to chemical engineering problems can be significantly improved by the use of simulation packages. However, it has been noted that few works have been focusing on elucidation of the use of open source packages for academic projects on process control. In fact, there is few online discussion groups aimed to the application of Xcos® package for chemical engineering projects. Given this, this work aims to apply the Xcos® for studying the implementation of the process control theory applied to chemical engineering projects, focusing on the development of control loops block diagrams, PID control tuning, and process response analysis. The purpose of the application is developing a virtual environment for academic discussion and repository of examples. The results of two benchmark case studies are illustrated, showing that the problems can be easily modified, allowing the student to solve other similar examples for future applications. For the first case, the settling time ranged from 24.067 to 72.492 min, while for the second case the stabilization time ranged from 5.301 to 20.904 min.The results evidence that the Xcos® software can be widely applied by the academic community, due to its simplicity and robustness in demonstrating the principal aspects of control theory.
Retinal vein thrombosis and risk of occult cancer: A nationwide cohort study
Authors: Hansen Anette Tarp , Veres Katalin , Prandoni Paolo , Adelborg Kasper , Sørensen Henrik Toft 
Published: September 2018

AbstractBackgroundRetinal vein thrombosis has in case reports been reported a clinical sign of cancer, especially hematological cancer. However, it is unclear whether retinal vein thrombosis is a marker of underlying cancer, as is the case for deep venous thrombosis and pulmonary embolism. We investigated the risk of occult cancer in patients with retinal vein thrombosis.MethodsA nationwide population‐based cohort study in Denmark on all patients diagnosed with a retinal vein thrombosis during 1994 and 2013. The main outcome measures were any cancer and site‐specific cancers <6 months, 6‐12 months, and 5 years following a retinal vein thrombosis diagnosis, as registered in the Danish Cancer Registry and the National Pathology Registry. We calculated the absolute cancer risk and computed standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) for cancer within <6 months, 6‐12 months, and 5 years following a retinal vein thrombosis diagnosis.ResultsAmong 9589 patients with retinal vein thrombosis, we observed 1514 cancer cases. The risk of any cancer was 1.2% <6 months and 28.8% after 5 years. The <6 months SIR was 1.20 (95% CI 0.99‐1.44), 6‐12 months SIR was 1.15 (95% CI 0.94‐1.39), and the 5 years’ SIR was 1.08 (95% CI 1.03‐1.14). Stratification by age, gender, calendar year, and Charlson Comorbidity Index score did not change overall cancer risk estimates.ConclusionRetinal vein thrombosis was not an important clinical marker for occult cancer. An extensive diagnostic cancer workup does not appear warranted for retinal vein thrombosis patients.
Suppression of ABCD2 dysregulates lipid metabolism via dysregulation of miR‐141:ACSL4 in human osteoarthritis
Authors: Park Sujeong , Oh Jinjoo , Kim Yong‐Il , Choe Seong‐Kyu , Chun Churl‐Hong , Jin Eun‐Jung 
Published: September 2018

Even though increasing evidence indicates the importance of peroxisomal lipid metabolism in regulating biological and pathological events, its involvement in cartilage development has not been well studied. Here, we identified the importance of peroxisomal function, particularly the functional integrity of ABCD2, in the pathogenesis of osteoarthritis (OA). Knockdown of ABCD2 in OA chondrocytes induced the accumulation of very long chain fatty acids (VLCFAs) and apoptotic cell death. Moreover, knockdown of ABCD2 altered profiles of miRNAs that affect the expression level of ACSL4, a known direct regulator of lipid metabolism. Suppression of ACSL4 in human chondrocytes‐induced VLCFA accumulation, MMP‐13 expression, and apoptotic cell death. In vivo morph‐down of the ACSL4 homologue in zebrafish resulted in significant defects in cartilage development and in vivo knockdown of ACSL4 in cartilage tissue of an OA model mice promoted severe cartilage degradation. In summary, to the best of our knowledge, this is the first report suggesting that the regulatory network among peroxisomal ABCD2:ACSL4:VLCFA serves as a novel regulator of cartilage homeostasis, and these data may provide novel insights into the role of peroxisomal fatty acid metabolism in pathogenesis of human OA.Significance of the studyOur study indicates that peroxisomal dysfunction is closely related to OA pathogenesis. Particularly, the functional integrity of ABCD2 may play an important role in OA pathogenesis via the accumulation of VLCFAs and stimulation of apoptotic death through altering profiles of miRNAs that target ACSL4. Our findings suggest that targeting the regulatory network among the peroxisomal ABCD2:ACSL4:VLCFA axis may provide a new potential therapeutic strategy for OA pathogenesis.
Characterization of aortic root geometry in transcatheter aortic valve replacement patients
Authors: Madukauwa‐David Immanuel David , Midha Prem A. , Sharma Rahul , McLain Kylee , Mitra Ronodeep , Crawford Kaylyn , Yoon Sung‐Han , Makkar Raj R. , Yoganathan Ajit P. 
Published: September 2018

AbstractPurposeThe study aimed to characterize the geometry of the aortic root pre‐ and post‐transcatheter aortic valve replacement (TAVR) and investigate differences in pre‐ and post‐TAVR anatomy.BackgroundA greater understanding of how aortic root geometry changes after TAVR is needed to facilitate further investigation into the hemodynamic profiles of the post‐TAVR aortic root.MethodsAnatomical measurements were conducted on de‐identified, retrospective post‐TAVR 4DCT scans of 109 patients with aortic stenosis obtained from the RESOLVE study. The diameter of the aortic root was measured at the level of the annulus, left ventricular outflow tract (LVOT), sinus of Valsalva, sinotubular junction (STJ) and ascending aorta. The heights of the STJ and coronary arteries were also measured.ResultsAll aortic root dimensions were normally distributed across the cohort and changed significantly between pre‐ and post‐TAVR conditions (P < 0.01). Post‐TAVR dimensions changed significantly from peak systole to end diastole (P < 0.01). Regression models were obtained for all aortic root dimensions in terms of annulus diameter with excellent coefficient of determination (R2 > 0.95, P < 0.001).ConclusionsThere are significant differences between pre‐ and post‐TAVR as well as peak systolic and end diastolic aortic root anatomy. Appropriate anatomical dimensions should be selected for benchtop testing as the geometry varies greatly throughout the cardiac cycle.
Contemporary practice pattern of revascularization in a large tertiary care referral center in non‐ST elevation myocardial infarction: A propensity‐matched 10‐year experience
Authors: Shetabi Kambiz , Ullah Rafath , Patel Raj , Wilson Thomas , Siddiqua Tasneem , Olet Susan , Ammar Khawaja Afzal , Jahangir Arshad , Allaqaband Suhail Q. , Bajwa Tanvir , Jan M. Fuad 
Published: September 2018

AbstractObjectivesWe sought to compare the effects of early versus delayed percutaneous coronary intervention (PCI) on the outcomes at 1 year in patients presenting with non‐ST‐segment elevation myocardial infarction (NSTEMI).BackgroundPrompt reperfusion in NSTEMI remains controversial. Randomized studies have shown conflicting results regarding the benefits of early intervention versus delayed intervention (defined as intervention performed within 24 hr vs. 24–72 hr of presentation, respectively). This study was conducted to determine the clinical outcomes post PCI in a large tertiary care center.MethodsA propensity‐matched group of 1,640 NSTEMI patients [62.4% males (n = 1,023), median age 65 years] was studied for a composite of death, myocardial infarction (MI), stroke, and heart failure in 1 year as a primary endpoint after PCI. Patients were divided into an early intervention group (EIG) and delayed intervention group (DIG). Timing of PCI was determined by the treating interventional cardiologist.ResultsThe primary outcome was significantly lower in the EIG than DIG (20.4% vs. 24.9%, P = 0.029), which was mainly derived from mortality benefit in the EIG. There was no difference in occurrence of death, MI, stroke, or heart failure between the groups at 30 days.ConclusionsAn earlier PCI in patients with NSTEMI is associated with a significant reduction in the composite outcome of death, MI, heart failure, or stroke at 1 year compared with delayed PCI. Based on this large cohort of patients from a real‐world referral center, contemporary reperfusion practices in NSTEMI may need to be re‐examined with a bias toward early intervention.
Evaluation of intracoronary hyperoxemic oxygen therapy in acute anterior myocardial infarction: The IC‐HOT study
Authors: David Shukri W. , Khan Zubair A. , Patel Nainesh C. , Metzger D. Christopher , Wood Frances O. , Wasserman Hal S. , Lotfi Amir S. , Hanson Ivan D. , Dixon Simon R. , LaLonde Thomas A. , Généreux Philippe , Ozan Melek Ozgu , Maehara Akiko , Stone Gregg W. 
Published: September 2018

AbstractBackgroundIn the randomized AMIHOT‐II trial, supersaturated oxygen [SSO2] delivered into the left anterior descending (LAD) artery via an indwelling intracoronary infusion catheter following primary percutaneous coronary intervention (PCI) significantly reduced infarct size in patients with anterior ST‐segment elevation myocardial infarction (STEMI) but resulted in a numerically higher incidence of safety events.ObjectivesThe IC‐HOT study evaluated the safety of SSO2 therapy selectively delivered to the left main coronary artery (LMCA) for 60 minutes after PCI in patients with anterior STEMI.MethodsSSO2 therapy was administered to the LMCA after stent implantation in 100 patients with anterior STEMI and proximal or mid‐LAD occlusion presenting within 6 hours of symptom onset. The primary endpoint was the 30‐day composite rate of net adverse clinical events (NACE) (death, reinfarction, clinically driven target vessel revascularization, stent thrombosis, severe heart failure, or TIMI major/minor bleeding) compared against an objective performance goal of 10.7%. Cardiac magnetic resonance imaging was performed at 4 and 30 days to assess infarct size.ResultsSSO2 delivery was successful in 98% of patients. NACE at 30 days occurred 7.1% of patients (meeting the primary safety endpoint of the study); there were no deaths, only one stent thrombosis and one case of severe heart failure. Median [interquartile range] infarct size was 24.1% [14.4%, 31.6%] at 4 days and 19.4% [8.8%, 28.9%] at 30 days.ConclusionFollowing primary PCI in acute anterior STEMI, infusion of SSO2 via the LMCA was feasible and was associated with a favorable early safety profile.
Manipulation of Fischer‐Tropsch Synthesis for Production of Higher Alcohols Using Manganese Promoters
Authors: Paterson James , Peacock Mark , Purves Russell , Partington Roy , Sullivan Kay , Sunley Glenn , Wilson Jon 
Published: September 2018

AbstractWhile Fischer‐Tropsch (FT) provides a commercially operated route to long‐chain alkanes for fuels, little is reported showing realistic routes to long‐chain linear alcohols and linear olefins. Linear olefins and alcohols have significant commercial value for lubricants, plasticizers, detergents and base chemicals, and in this contribution, FT has gained considerable recent attention due to the potential for bio or waste feeds for fuels and chemicals, while here we demonstrate that controlling the promotion of a cobalt catalyst with manganese can lead to major shifts in selectivity towards high value chemicals. In this contribution, we demonstrate the unusual effect of adjusting manganese from 0–10 % for making long‐chain linear alcohols and olefins using industrially relevant conditions. A full evaluation of the catalysts is provided to demonstrate catalyst changes as a result of increased promotion that gives rise to this effect. Advanced wax‐product analysis is shown to demonstrate the changes in selectivity. Temperature‐programmed reduction, transmission electron microscopy elemental mapping and in situ x‐ray diffraction show the formation of CoxMnyO4 species on titania during synthesis, with cobalt‐manganese alloys after reduction, while 2D gas chromatography (GCxGC) and 1H nmR were used to analyse the FT wax product with over 50 % alcohols at long carbon numbers.
Facile Synthesis of Mesoporous Nickel Cobalt Oxide for OER – Insight into Intrinsic Electrocatalytic Activity
Authors: Broicher Cornelia , Zeng Feng , Artz Jens , Hartmann Heinrich , Besmehn Astrid , Palkovits Stefan , Palkovits Regina 
Published: September 2018

AbstractThe development of novel metal oxide catalysts for electrochemical water splitting has been one of the future challenges in catalysis. We present the development of structured spinel based NiCo2O4 materials using in‐situ hydrothermal synthesis and KIT‐6 as a template. Their electron transfer kinetics in the oxygen evolution reaction (OER) at pH 14 are studied. Structuring of NiCo2O4 via KIT‐6 improves the intrinsic catalyst performance, e. g., a lower overpotential of ∼350 mV and a good long‐term stability could be observed compared to 385 mV and poor stability of commercially available NiCo2O4. Kinetic studies provided insights into structure‐activity relations and the nature of the electrode/electrolyte interface. Interestingly, structuring via KIT‐6 increases not only the electrochemical surface area but also the current density accompanied by superior charge transfer capacity.
Biocatalytic Cascade Reaction for the Asymmetric Synthesis of L‐ and D‐Homoalanine
Authors: Silva Marcus V. de M. , Costa Ingrid C. R. , de Souza Rodrigo O. M. A. , Bornscheuer Uwe T. 
Published: September 2018

AbstractUnnatural amino acids attract growing attention for pharmaceutical applications as they are useful building blocks for the synthesis of a number of chiral drugs. Here, we describe a two‐step enzymatic method for the asymmetric synthesis of homoalanine from L‐methionine, a cheap and readily available natural amino acid. First, the enzyme L‐methionine γ‐lyase (METase), from Fusobacterium nucleatum, catalyzed the γ‐elimination of L‐methionine to 2‐oxobutyrate. Second, an amino acid aminotransferase catalyzed the asymmetric conversion of 2‐oxobutyrate to either L‐ or D‐homoalanine. The L‐branched chain amino acid aminotransferase from Escherichia coli (eBCAT), using L‐glutamate as amino donor, produced L‐homoalanine (32.5 % conv., 28 % y, 99 % ee) and the D‐amino acid aminotransferase from Bacillus sp. (DATA) used D‐alanine as amino donor to produce D‐homoalanine (87.5 % conv., 69 % y, 90 % ee). Thus, this concept allows for the first time the synthesis of both enantiomers of this important unnatural amino acid.
Pyrrolidine‐Based P,O Ligands from Carbohydrates: Easily Accessible and Modular Ligands for the Ir‐Catalyzed Asymmetric Hydrogenation of Minimally Functionalized Olefins
Authors: Elías‐Rodríguez Pilar , Borràs Carlota , Carmona Ana T. , Faiges Jorge , Robina Inmaculada , Pàmies Oscar , Diéguez Montserrat 
Published: September 2018

AbstractThe potential of P,O‐iminosugar based ligands in the Ir‐catalyzed asymmetric hydrogenation of minimally functionalized olefins is presented. These new ligands were prepared from easily available carbohydrates (D‐mannose, D‐ribose and D‐arabinose). The stereochemical and polyfunctional diversity of carbohydrates allowed the modulation of the ligands, both from their electronic properties and the rigidity of their backbone. High enantioselectivities (ee’s up to 99 %) can be reached in the hydrogenation of selected tri‐ and disubstituted substrates.
Statistical Optimization of the Biodiesel Production Process Using a Magnetic Core‐Mesoporous Shell KOH/Fe3O4@γ‐Al2O3 Nanocatalyst
Authors: Ghalandari Atena , Taghizadeh Majid , Rahmani Mohsen 
Published: September 2018

AbstractA magnetic core‐mesoporous shell KOH/Fe3O4@γ‐Al2O3 nanocatalyst was synthesized using the Fe3O4@γ‐Al2O3 core‐shell structure as support and KOH as active component. The prepared samples were characterized by X‐ray diffraction (XRD), field‐emission scanning electron microscopy (FE‐SEM), energy‐dispersive X‐ray spectroscopy (EDS), Fourier transform infrared (FTIR), Brunauer‐Emmett‐Teller (BET), and vibrating sample magnetometry (VSM) techniques. Transesterification of canola oil to methyl esters (biodiesel) in the presence of the magnetic core‐mesoporous shell KOH/Fe3O4@γ‐Al2O3 nanocatalyst was investigated. Response surface methodology (RSM) based on the Box‐Behnken design (BBD) was employed to optimize the influence of important operating variables on the yield of biodiesel. A biodiesel yield of 97.4 % was achieved under optimum reaction conditions. There was an excellent agreement between experimental and predicted results.