bluuebunny/crossref_metadata_2025_split huggingface dataset:
S2S reboot: An argument for greater inclusion of machine learning in subseasonal to seasonal forecasts
Authors: Cohen Judah , Coumou Dim , Hwang Jessica , Mackey Lester , Orenstein Paulo , Totz Sonja , Tziperman Eli 
Published: December 2018

The discipline of seasonal climate prediction began as an exercise in simple statistical techniques. However, today the large government forecast centers almost exclusively rely on complex fully coupled dynamical forecast systems for their subseasonal to seasonal (S2S) predictions while statistical techniques are mostly neglected and those techniques still in use have not been updated in decades. In this Opinion Article, we argue that new statistical techniques mostly developed outside the field of climate science, collectively referred to as machine learning, can be adopted by climate forecasters to increase the accuracy of S2S predictions. We present an example of where unsupervised learning demonstrates higher accuracy in a seasonal prediction than the state‐of‐the‐art dynamical systems. We also summarize some relevant machine learning methods that are most applicable to climate prediction. Finally, we show by comparing real‐time dynamical model forecasts with observations from winter 2017/2018 that dynamical model forecasts are almost entirely insensitive to polar vortex (PV) variability and the impact on sensible weather. Instead, statistical forecasts more accurately predicted the resultant sensible weather from a mid‐winter PV disruption than the dynamical forecasts. The important implication from the poor dynamical forecasts is that if Arctic change influences mid‐latitude weather through PV variability, then the ability of dynamical models to demonstrate the existence of such a pathway is compromised. We conclude by suggesting that S2S prediction will be most beneficial to the public by incorporating mixed or a hybrid of dynamical forecasts and updated statistical techniques such as machine learning.This article is categorized under:

Climate Models and Modeling > Knowledge Generation with Models
Industrial IoT cross‐layer forensic investigation
Authors: Rondeau Christopher M. , Temple Michael A. , Lopez Juan 
Published: December 2018

Cross‐layer forensic investigation is addressed for Industrial Internet of Things (IIoT) device attacks in Critical Infrastructure (CI) applications. The operational motivation for cross‐layer investigation is provided by the desire to directly correlate bit‐level network anomaly detection with physical layer (PHY) device connectivity and/or status (normal, defective, attacked, etc.) at the time of attack. The technical motivation for developing cross‐layer techniques is motivated by (a) having considerable capability in place for Higher‐Layer Digital Forensic Information exploitation—real‐time network cyberattack and postattack analysis, (b) having considerably less capability in place for Lowest‐Layer PHY Forensic Information exploitation—the PHY domain remains largely under exploited, and (c) considering cyber‐physical integration as a means to jointly exploit higher‐layer digital and lowest‐layer PHY forensic information to maximize investigative benefit in IIoT cyber forensics. A delineation of higher‐layer digital and lowest‐layer PHY elements is provided for the standard network Open Systems Interconnection model and the specific Perdue Enterprise Reference Architecture commonly used in IIoT Industrial Control System/Supervisory Control and Data Acquisition applications. A forensics work summary is provided for each delineated area based on selected representative publications and provides the basis for presenting the envisioned cross‐layer forensic investigation.This article is categorized under:

Digital and Multimedia Science > Cyber Threat Intelligence
Digital and Multimedia Science > IoT Forensics
Expanding universe and dynamical compactification using Yang-Mills instantons
Authors: Kim Kyung Kiu , Koh Seoktae , Yang Hyun Seok 
Published: December 2018

AbstractWe consider an eight-dimensional Einstein-Yang-Mills theory to explore whether Yang-Mills instantons formed in extra dimensions can induce the dynamical instability of our four-dimensional spacetime. We show that the Yang-Mills instantons in extra dimensions can trigger the expansion of our universe in four-dimensional spacetime as well as the dynamical compactification of extra dimensions. We also discuss a possibility to realize a reheating mechanism via the quantum back-reaction from the contracting tiny internal space with a smeared instanton.
Intestinal constipation in the elderly and associated factors – SABE Study
Authors: Gomes Sâmia , Duarte Yeda Aparecida de Oliveira , Santos Jair Licio Ferreira 
Published: December 2018

Abstract
Introduction Constipation is understood to be a chronic problem related to a multi-functional disorder that affects approximately 20% of the world population, and it is more prevalent in women and in the elderly.
Objective To measure the prevalence of intestinal constipation in elderly people living in São Paulo, as well as the factors associated with this condition.
Methods This was a cross-sectional study using the SABE study database (Health, Well-being and Ageing) from 2010 with a probabilistic sample of 1345 elderly people (≥ 60 years) living in São Paulo city, both male and female. Logistic regression was used to identify factors associated with intestinal constipation.
Results and conclusion The prevalence of intestinal constipation in older people is 14.23%. The associated factors were joint pain, osteoporosis, and use of laxatives; in women, associated factors were antidepressants and diuretics.
Timing of neoadjuvant therapy and surgical treatment in rectal cancer
Authors: Gouveia Manuel Campos de , Barbosa Laura Elisabete Ribeiro 
Published: December 2018

Abstract
Study objectives To evaluate the ideal timing between neoadjuvant therapy and surgical treatment of rectal cancer, as well as the influence on treatment outcomes.
Methods Using PubMed, a systematic literature search was made on the influence of surgery timing after chemoradiotherapy in treating rectal cancer.
Results and discussion A total of 34 articles published until April 2017 were analyzed. Nine of them were randomized clinical trials, one was a non-randomized trial, 23 were retrospective studies, and one was a meta-analysis. These studies compared treatment intervals varying between two and 19 weeks. Intervals of nine to 14 weeks showed increased tumor downstaging and higher rates of complete pathological response. These intervals shown safety for patients. Nonetheless, few studies showed differences in overall survival. The most used intervals between neoadjuvant chemoradiotherapy are six to eight weeks. Despite that, intervals longer than these show potential benefits for patients without putting them at risk of disease progression. Studies evaluating the effect of overall survival and long-term recurrence are scarce.
Conclusion Programming surgery more than eight weeks after chemoradiotherapy seems preferable to the six to eight weeks most recently practiced, increasing tumor downstaging and having higher complete pathological response rates.
Potential clinical applications of circulating cell-free DNA in ovarian cancer patients
Authors: Barbosa Ana , Peixoto Ana , Pinto Pedro , Pinheiro Manuela , Teixeira Manuel R. 
Published: December 2018

AbstractCirculating cell-free DNA (cfDNA) consists of small fragments of DNA that circulate freely in the bloodstream. In cancer patients, a fraction of cfDNA is derived from tumour cells, therefore containing the same genetic and epigenetic alterations, and is termed circulating cell-free tumour DNA. The potential use of cfDNA, the so-called ‘liquid biopsy’, as a non-invasive cancer biomarker has recently received a lot of attention. The present review will focus on studies concerning the potential clinical applications of cfDNA in ovarian cancer patients.
Higher rank rigidity for Berwald spaces
Authors: WU WEISHENG 
Published: December 2018

We generalize the higher rank rigidity theorem to a class of Finsler spaces, i.e. Berwald spaces. More precisely, we prove that a complete connected Berwald space of finite volume and bounded non-positive flag curvature with rank at least two whose universal cover is irreducible is a locally symmetric space or a locally Minkowski space.
Culturable bacteria isolated from seven high-altitude ice cores on the Tibetan Plateau
Authors: LIU YONGQIN , PRISCU JOHN C. , YAO TANDONG , VICK-MAJORS TRISTA J. , MICHAUD ALEXANDER B. , SHENG LIANG 
Published: December 2018

ABSTRACTMicroorganisms are the most abundant organisms on Earth, and microbial abundance records preserved in ice cores have been connected to records of environmental change. As an alternative to high resolution abundance records, which can be difficult to recover, we used culture-dependent and culture-independent methods to examine bacteria in glacier ice from the Tibetan Plateau (TP). We recovered a total of 887 bacterial isolates from ice cores of up to 164 m in depth retrieved from seven glaciers, located across the TP. These isolates were related to 53 genera in theActinobacteria,Firmicutes,Bacteroidetes, andProteobacteria, with 13 major genera accounting for 78% of isolates. Most of the genera were common across the geographic region covered by our sampling, but there were differences in the genera recovered from different depths in the ice, with the deepest portions of the ice cores dominated by a single genus (Sporosarcina). Because microorganisms deposited on glaciers must survive atmospheric transport under a range of temperatures, temperature tolerance should be an important survival mechanism. We tested isolate growth across a range of temperatures (0–35 °C), and found psychrotolerance to be common. Together, our results show that ice depth, and by extension age, are characterized by different types of microorganisms, providing new information about microbial records in ice.
In situ measurement of MWA primary beam variation using ORBCOMM
Authors: Line J. L. B. , McKinley B. , Rasti J. , Bhardwaj M. , Wayth R. B. , Webster R. L. , Ung D. , Emrich D. , Horsley L. , Beardsley A. , Crosse B. , Franzen T. M. O. , Gaensler B. M. , Johnston-Hollitt M. , Kaplan D. L. , Kenney D. , Morales M. F. , Pallot D. , Steele K. , Tingay S. J. , Trott C. M. , Walker M. , Williams A. , Wu C. 
Published: December 2018

AbstractWe provide the first in situ measurements of antenna element beam shapes of the Murchison Widefield Array. Most current processing pipelines use an assumed beam shape, which can cause absolute and relative flux density errors and polarisation ‘leakage’. Understanding the primary beam is then of paramount importance, especially for sensitive experiments such as a measurement of the 21-cm line from the epoch of reionisation, where the calibration requirements are so extreme that tile to tile beam variations may affect our ability to make a detection. Measuring the primary beam shape from visibilities is challenging, as multiple instrumental, atmospheric, and astrophysical factors contribute to uncertainties in the data. Building on the methods of Neben et al. [Radio Sci., 50, 614], we tap directly into the receiving elements of the telescope before any digitisation or correlation of the signal. Using ORBCOMM satellite passes we are able to produce all-sky maps for four separate tiles in the XX polarisation. We find good agreement with the beam model of Sokolowski et al. [2017, PASA, 34, e062], and clearly observe the effects of a missing dipole from a tile in one of our beam maps. We end by motivating and outlining additional on-site experiments.
Flexural subsidence analysis of the Laxmi Basin, Arabian Sea and its tectonic implications
Authors: Pandey D. K. , Pandey Anju , Clift Peter D. , Nair Nisha , Ramesh Prerna , Kulhanek Denise K. , Yadav Rajeev 
Published: December 2018

AbstractTwo-dimensional flexural backstripping and thermal modelling (assuming laterally variable stretching) is applied along regional depth-converted interpreted seismic profiles from the Laxmi Basin in the Arabian Sea. Results from reverse post-rift flexural modelling reveal considerable basin-wide subsidence in response to the crustal geodynamics during and after the last extensional phase. Unloading of the stratigraphy allows us to estimate the degree of laterally varying extension, assuming thermal subsidence and pure shear. High degrees of extension in the basin centre predict considerable water depths at the time of rift cessation, consistent with deep drilling data. We suggest that regional extension prior to Paleocene time could have fuelled variable subsidence in the Laxmi Basin but that extension is less than seen in typical oceanic lithosphere. Volcanic loading by the seamounts shortly after extension has flexed the basin and implies an effective elastic thickness (Te) at that time of ∼6 km. Reconstruction of the seamount top near sea level at the end of emplacement indicates no major transient uplift potentially linked to the Deccan mantle plume activity. Backstripping of post-rift sediments from interpreted seismic profiles supports the presence of a hyper-thinned crust underneath the Laxmi Basin, with β factors reaching >7 in the basin centre and ∼3 across much of the basin width. Computations of decompacted sediment accumulation rates in light of new results from IODP Expedition 355 show that basin sedimentation peaked during early–middle Miocene time, possibly coeval with uplift and erosion of the Himalayan–Tibetan Plateau driven by strong summer monsoon rains.
Constructing Justice: The Selective Use of Scripture in Formulating Early Jewish Accounts of the Courts
Authors: Flatto David C. 
Published: December 2018

AbstractElaborate depictions of the court system in Second Temple and rabbinic literature signify its centrality for the Jewish legal tradition. Rather than offering positivistic descriptions, these representations are better thought of as templates of how to organize justice. While historically less informative, they are vivid expressions of the early Jewish legal imagination and its fascinating fixation on the architecture of justice.A measure of the ahistoric quality of early accounts of judicial administration is their considerable exegetical strata. This article surveys how four seminal Second Temple and rabbinic works constructed accounts of the judiciary on the foundation of Scripture. The variances among them unfold from decisive hermeneutical choices, beginning with the threshold question of which among several, internally inconsistent, biblical sources to select as a base text. What animates these various choices, in turn, are competing conceptions of the origin and nature of legal authority within a religious tradition that enshrines the role of law.
Surgical histoanatomy for adduction arytenopexy using injection laryngoplasty
Authors: Sato K , Chitose S , Sato F , Umeno H 
Published: December 2018

AbstractBackgroundIn order to improve a large posterior glottal gap and/or aspiration, injections of augmentation substances should not only be administered at the mid-membranous vocal fold in the thyroarytenoid muscle, but also at the cartilaginous portion of the vocal fold to make adduction arytenopexy possible.MethodTen adult human larynges were investigated using the whole-organ serial section technique.ResultsVertical thickness of the posterior aspect of the thyroarytenoid muscle was relatively thin (3.4 ± 0.4 mm), especially in females (3.2 ± 0.3 mm). Consequently, care should be taken to ensure the correct depth of needle placement. If the needle is placed too deep, augmentation substances are injected into the lateral cricoarytenoid muscle, located beneath the thyroarytenoid muscle, or into the paraglottic space, located inferolateral to the thyroarytenoid muscle.ConclusionThe injection location and the amount of injected material should be modified based on the pathological conditions of the voice disorder and aspiration.
Sampling estuarine copepods at different scales and resolutions: a study in Rio de la Plata
Authors: Paul Sourav , Calliari Danilo 
Published: December 2018

AbstractIn the Rio de la Plata salinity, temperature, chlorophyll a (chl a), and densities (ind. m−3) of the copepods Acartia tonsa and Paracalanus parvus were measured from January to November in 2003 by following a nested weekly and monthly design. Such sampling yielded two separate datasets: (i) Yearly Dataset (YD) which consists of data of one sampling effort per month for 11 consecutive months, and (ii) Seasonal Weekly Datasets (SWD) which consists of data of one sampling effort per week of any four consecutive weeks within each season. YD was assumed as a medium-term low-resolution (MTLR) dataset, and SWD as a short-term high-resolution (STHR) dataset. The hypothesis was, the SWD would always capture (shorter scales generally captures more noise in data) more detail variability of copepod populations (quantified through the regression relationships between temporal changes of salinity, temperature, chl a and copepod densities) than the YD. Analysis of both YD and SWD found that A. tonsa density was neither affected by seasonal cycles, nor temporal variability of salinity, temperature and chl a. Thus, compared to STHR sampling, MTLR sampling did not yield any further information of the variability of population densities of the perennial copepod A. tonsa. Analysis of SWD found that during summer and autumn the population densities of P. parvus had a significant positive relationship to salinity but their density was limited by higher chl a concentration; analysis of YD could not yield such detailed ecological information. That hints the effectiveness of STHR sampling over MTLR sampling in capturing details of the variability of population densities of a seasonal copepod species. Considering the institutional resource limitations (e.g. lack of long-term funding, manpower and infrastructure) and the present hypothesis under consideration, the authors suggest that a STHR sampling may provide useful complementary information to interpret results of longer-term natural changes occurring in estuaries.
Neospora caninum cytoplasmic dynein LC8 light chain 2 (NcDYNLL2) is differentially produced by pathogenically distinct isolates and regulates the host immune response
Authors: Cao Lili , Fetterer Raymond , Qu Guanggang , Zhang Xichen , Tuo Wenbin 
Published: December 2018

AbstractNeospora caninum is the causative agent of bovine neosporosis. A N. caninum cytoplasmic dynein LC8 light chain (NcDYNLL) protein was characterized in this study. Cytoplasmic dyneins, including DYNLLs, belong to the microtubule minus-end-directed motor proteins and are involved in many cellular processes. Previous microarray studies revealed that NcDYNLL was downregulated in the non-pathogenic clone, Ncts-8, when compared with the wild-type NC1 isolate. The present study showed that DYNLLs from different species are highly conserved (>85% identity), and the NcDYNLL belongs to the DYNLL2 family. NcDYNLL2 and Toxoplasma gondii DYNLL2 have identical amino acid sequences, although they are slightly divergent at the genetic level (89% identity). NcDYNLL2 was cloned and expressed in Escherichia coli and purified. NcDYNLL2 was identified in soluble and insoluble fractions of tachyzoite lysate. As expected, soluble NcDYNLL2 was lower in the Ncts-8 lysate when compared with that of NC1 isolate. NcDYNLL2 release by the tachyzoites was low; however, it was increased when tachyzoites were treated with either calcium ionophore or ethanol. The data indicate that NcDYNLL2 may be actively secreted at low levels, but the secretion was upregulated by agents that also augment microneme protein secretions. Immunostaining of NcDYNLL2 in isolated and intracellular Neospora tachyzoites showed a diffuse distribution pattern. Furthermore, rNcDYNLL2 was internalized by the host immune cells and stimulated tumour necrosis factor-α) and interleukin-12 (IL-12) production by murine dendritic cells. Taken together, these results suggest that NcDYNLL2 is a secretory protein that cross-regulates host immunity.
On The Soul
Authors: Morris Herbert 
Published: December 2018

AbstractDiscussion of the soul in this essay departs from the concept of the soul that for thousands of years has occupied the attention of philosophers and theologians and pervaded religious discourse. The author is concerned with what William James referred to as ‘the popular soul,’ the soul as it is invoked by expressions such as ‘an expansive soul,’ ‘a soulless person,’ ‘soul-mate,’ and ‘that melody touched my soul.’ Skepticism with regard to the existence of this soul is without warrant. How this soul comes into being and develops; what its essential features are; how the world, when the soul is engaged, is transformed; what its relationship is to one's conscience; its importance in a human life; its connections to purity and perfection, to silence; its survival upon death; and the perils posed today to its development and existence are the principal topics considered.
Education and outreach by the Antarctic Treaty Parties, Observers and Experts under the framework of the Antarctic Treaty Consultative Meetings
Authors: Xavier José C. , Mateev Dragomir , Capper Linda , Wilmotte Annick , Walton David W. H. 
Published: December 2018

AbstractThe development of formal discourse about education and outreach within the Antarctic Treaty Consultative Meetings (ATCM), and the influence of major international activities in this field, are described. This study reflects on the ATCM Parties’ approach to implementing the ambition of the Protocol on Environmental Protection to the Antarctic Treaty Article 6.1.a, to promote the educational value of Antarctica and its environment, and examines the role of workshops and expert groups within the Scientific Committee on Antarctic Research (SCAR), the International Union for the Conservation of Nature (IUCN), and the Council of Managers of National Antarctic Programmes. These early initiatives, which emerged in the 1990s, were a prelude to the development and implementation of a large number of International Polar Year (IPY) education and outreach programmes. The establishment of an Antarctic Treaty System Intersessional Contact Group, and an online forum on education and outreach during the 2015 ATCM in Bulgaria, is a legacy of IPY and is the next step in fostering collaboration to engage people around the world in the importance and relevance of Antarctica to our daily lives.