bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual MAPK/CDK Targeting in Melanoma: New Approaches, New Challenges
Authors: Sullivan Ryan J. 
Published: May 2018

Abstract
Summary: Dual MAPK and CDK4/6 targeting is an emerging strategy in melanoma, but toxicity and acquired resistance are limitations. In this issue, two groups (Teh and colleagues and Romano and colleagues) show that therapeutic resistance mechanisms converge on the PI3K pathway, and inhibition of this pathway's mediators can overcome this resistance. Cancer Discov; 8(5); 532–3. ©2018 AACR.
See related article by Romano et al., p. 556.
See related article by Teh et al., p. 568.
Hallmarks of T-cell Exit from Quiescence
Authors: Chapman Nicole M. , Chi Hongbo 
Published: May 2018

AbstractThe appropriate activation of the adaptive immune system relies upon the reprogramming of naïve T cells into specialized effector T cells that can combat pathogens and tumors. Naïve T cells are actively maintained in a state of hyporesponsiveness termed quiescence, which is characterized by small cell size, low proliferative rate, and low basal metabolism. Engagement of antigen and costimulatory receptors drives T cells to exit quiescence to promote subsequent clonal expansion and functional differentiation. The exit from quiescence, which precedes activation-induced proliferation, is associated with extensive remodeling of cellular morphology and metabolism. Here, we define and discuss the implications of the six key features of the exit of naïve T cells from quiescence: (i) cell-cycle entry, (ii) cell growth, (iii) autocrine or paracrine interleukin-2 signaling, (iv) anabolic metabolism, (v) nutrient uptake, and (vi) remodeling of mitochondrial function. Ultimately, understanding how naïve T cells meet each of these requirements for quiescence exit will allow for the tuning of T-cell responses to treat infectious diseases, autoimmunity, and cancer. Cancer Immunol Res; 6(5); 502–8. ©2018 AACR.
Load-Dependent Changes in Left Ventricular Structure and Function in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure
Authors: Weinheimer Carla J. , Kovacs Attila , Evans Sarah , Matkovich Scot J. , Barger Philip M. , Mann Douglas L. 
Published: May 2018

Background:
To better understand reverse left ventricular (LV) remodeling, we developed a murine model wherein mice develop LV remodeling after transverse aortic constriction (TAC) and a small apical myocardial infarct (MI) and undergo reverse LV remodeling after removal of the aortic band.

Methods and Results:
Mice studied were subjected to sham (n=6) surgery or TAC+MI (n=12). Two weeks post-TAC+MI, 1 group underwent debanding (referred to as heart failure debanding [HF-DB] mice; n=6), whereas the aortic band remained in a second group (heart failure [HF] group; n=6). LV remodeling was evaluated by 2D echocardiography at 1 day, 2 weeks and 6 weeks post-TAC+MI. The hearts were analyzed by transcriptional profiling at 4 and 6 weeks and histologically at 6 weeks. Debanding normalized LV volumes, LV mass, and cardiac myocyte hypertrophy at 6 weeks in HF-DB mice, with no difference in myofibrillar collagen in the HF and HF-DB mice. LV ejection fraction and radial strain improved after debanding; however, both remained decreased in the HF-DB mice relative to sham and were not different from HF mice at 6 weeks. Hemodynamic unloading in the HF-DB mice was accompanied by a 35% normalization of the HF genes at 2 weeks and 80% of the HF genes at 4 weeks.

Conclusions:
Hemodynamic unloading of a pathophysiologically relevant mouse model of HF results in normalization of LV structure, incomplete recovery of LV function, and incomplete reversal of the HF transcriptional program. The HF-DB mouse model may provide novel insights into mechanisms of reverse LV remodeling.
Taking the Reins on Systems of Care for ST-Segment–Elevation Myocardial Infarction Patients
Authors: Green Jacqueline L. , Jacobs Alice K. , Holmes DaJuanicia , Chiswell Karen , Blanco Rosalia , Bates Eric R. , French William , Kupas Douglas F. , Mears Greg , Roe Matthew , Nallamothu Brahmajee K. 
Published: May 2018

Background—
Early success with regionalization of ST-segment–elevation myocardial infarction (STEMI) care has led many states to adopt statewide prehospital STEMI hospital destination policies, allowing emergency medical services to bypass non–percutaneous coronary intervention–capable hospitals. The association between adoption of these policies and patterns of care among STEMI patients is unknown.

Methods and Results—
Using data from January 1, 2013, to December 31, 2014, from the National Cardiovascular Data Registry and Acute Coronary Treatment and Intervention Outcomes Network Registry, 6 states with bypass policies (cases included Delaware, Iowa, Maryland, North Carolina, Pennsylvania, and Massachusetts) were matched to 6 states without bypass policies (controls included South Carolina, Minnesota, Virginia, Texas, New York, and Connecticut) a priori on region, hospital density, and percent state participation in the registry. Using the matched sample, logistic regression models were adjusted for patient- and state-level characteristics. Outcomes were receipt of reperfusion and receipt of timely percutaneous coronary intervention. Our study cohort included 19 287 patients at 379 sites across 12 states. Patients from states with hospital destination policies were similar in age, sex, and comorbidities to patients from states without such policies. After adjustment for patient- and state-level characteristics, 57.9% (95% confidence intervals, 53.2%–62.5%) of patients living in states with hospital destination policies when compared with 47.5% (95% confidence intervals, 43.4%–51.7%) living in states without hospital destination policies received primary percutaneous coronary intervention within their relevant guideline-recommended time from first medical contact.

Conclusions—
Statewide adoption of STEMI hospital destination policies allowing emergency medical services to bypass non–percutaneous coronary intervention–capable facilities is associated with significantly faster treatment times for patients with STEMI.
Increased Reticulon 3 (RTN3) Leads to Obesity and Hypertriglyceridemia by Interacting With Heat Shock Protein Family A (Hsp70) Member 5 (HSPA5)
Authors: Xiang Rong , Fan Liang-liang , Huang Hao , Chen Ya-qin , He Wanxia , Guo Shuai , Li Jing-Jing , Jin Jie-yuan , Du Ran , Yan Riqiang , Xia Kun 
Published: May 2018

Background:
Reticulon 3 (RTN3) is an endoplasmic reticulum protein that has previously been shown to play a role in neurodegenerative diseases, but little is known about its role in lipid metabolism.

Methods:

Obese patients (n=149), hypertriglyceridemic patients (n=343), and healthy control subjects (n=84) were enrolled to assess their levels of RTN3. To explore the pathophysiological roles of RTN3 in the control of lipid metabolism, we used transgenic mice overexpressing the wild-type human RTN3 gene, the RTN3-null transgenic mouse model, and multiple
Caenorhabditis legans
strains for molecular characterization. The underlying mechanisms were studied with 3T3L1 cell cultures in vitro.

Results:
We report that overexpressed RTN3 in mice induces obesity and higher accumulation of triglycerides. Increased RTN3 expression is also found in patients with obesity and hypertriglyceridemia. We reveal that RTN3 plays critical roles in regulating the biosynthesis and storage of triglycerides and in controlling lipid droplet expansion. Mechanistically, RTN3 regulates these events through its interactions with heat shock protein family A (Hsp70) member 5, and this enhanced interaction increases sterol regulatory element-binding protein 1c and AMP-activated kinase activity.

Conclusions:
This study provides evidence for a role of RTN3 in inducing obesity and triglyceride accumulation and suggests that inhibiting the expression of RTN3 in fat tissue may be a novel therapeutic approach to treat obesity and hypertriglyceridemia.
Whose Justice? Which Democracy? Justice, Reconciliation and Democracy in Post-Genocide Rwanda—Challenges to Public Theology
Authors: Schliesser Christine 
Published: May 2018

Abstract
How can a public theology advance the task of democracy in order to bring forth justice for all? This article focuses on post-genocide Rwanda as a current example of a country’s quest for justice, reconciliation and democratization after severe violent conflict. The first part traces the historical background of the Rwandan genocide with specific attention on the lack of just and democratic structures in pre-genocide Rwanda and the roles of the Christian churches therein. The second part explores the Christian churches’ involvement in the country’s current reconciliation process. Here, the Presbyterian Church of Rwanda (EPR) serves as a case study. The third part critically assesses the churches’ contribution to reconciliation with regards to how it serves to enhance—or hinder—the implementation of just and democratic structures.
Critical for Whom? Genealogy and the Limits of History
Authors: Carlson Liane 
Published: May 2018

AbstractThis article explores the relationships between the critical and persuasive claims of genealogy. It begins by contesting a recent trend in scholarship that insists genealogies are meant to dismantle metaphysical ideas, not persuade concrete individuals to give up their beliefs. It argues such an interpretation conflates genealogical critique into Kantian, excises the role of the reader, and illegitimately allows genealogists to escape the question of whether the method’s efficacy is historically contingent. The second section investigates the assumptions about the historical position and normative commitments of both the genealogist and the reader that must be in place for genealogy’s critical work to become persuasive. It then questions whether those assumptions are compatible with the basic commitments of genealogy as outlined by Nietzsche and Foucault. The final section asks whether structures of authority such that genealogy as a tool still addresses the authority structures of the present moment.
Quakers Reading Mystics
Authors: Birkel Michael 
Published: May 2018

AbstractOver the centuries, Quakers have read non-Quakers regarded as mystics. This study explores the reception of mystical texts among the Religious Society of Friends, looking particularly at Robert Barclay and John Cassian, Sarah Lynes Grubb and Jeanne Guyon, Caroline Stephen and Johannes Tauler, Rufus Jones and Jacob Boehme, and Teresina Havens and Buddhist texts selected by her. Points of connection include the nature of apophatic prayer, suffering and annihilation of self, mysticisms of knowing and of loving, liberal Protestant attitudes toward theosophical systems, and interfaith encounter.
Hurricane Kinetic Energy Spectra from In Situ Aircraft Observations
Authors: Vonich P. Trent , Hakim Gregory J. 
Published: May 2018

Abstract
Since the pioneering paper by Nastrom and Gage on aircraft-derived power spectra, significant progress has been made in understanding the wavenumber distribution of energy in Earth’s atmosphere and its implications for the intrinsic limits of weather forecasting. Improvements in tropical cyclone intensity predictions have lagged those of global weather forecasting, and limited intrinsic predictability may be partially responsible. In this study, we construct power spectra from aircraft data of over 1200 missions carried out by the National Oceanic and Atmospheric Administration (NOAA) and Air Force Reserve Command (AFRC) Hurricane Hunters. Each mission is parsed into distinct flight legs, and legs meeting a specified set of criteria are used for spectral analysis. Here, we produce power spectra composites for each category of the Saffir–Simpson scale, revealing a systematic relationship between spectral slope and storm intensity. Specifically, as storm intensity increases, we find that 1) spectral slope becomes steeper across scales from 10 to 160 km and 2) the transition zone where spectral slope begins to steepen shifts downscale.
Vapor Condensation in Rice Fields and Its Contribution to Crop Evapotranspiration in the Subtropical Monsoon Climate of China
Authors: Liu Xiaoyin , Xu Junzeng , Yang Shihong , Zhang Jiangang , Wang Yijiang 
Published: May 2018

Abstract
While vapor condensation in arid and semiarid areas has garnered much attention, such information is scarce for humid crop production areas such as rice fields. In a water-saving irrigation (WSI) rice field, high-precision weighed microlysimeters allowed the direct and independent quantification of condensation over plants (Cc) and soil (Cs) through mass balance calculations. The occurrence frequency and rate of Cc generally exceeded that of Cs. Predominantly occurring between sunset and sunrise, particularly between 0400 and 0500 local time, Cc showed an overall maximum rate of 0.096 mm h−1. In contrast, Cs was highest between 0100 and 1100 local time and showed an overall maximum rate of 0.044 mm h−1. The occurrence of Cc, unlike that of Cs, required a surface temperature lower than the ambient temperature or dewpoint. Of 65 rain-free days, Cc and Cs occurred on 60 and 33 days, respectively. Seasonal Cc, Cs, and Cc + Cs were estimated as 32.3, 3.1, and 35.4 mm, respectively, and their contributions to seasonal rice transpiration T, evaporation E, and evapotranspiration (ET) were 9.5%, 1.6%, and 6.7%, respectively. The seasonal Cc + Cs was similar in magnitude to a routine irrigation quota and accounted for 10.8% of rainfall and 14.4% of irrigation in the WSI rice field. Therefore, vapor condensation in rice fields in a subtropical monsoon climate is an important component of the hydrological cycle and cannot be ignored when tabulating the field water balance, calculating field water consumption, or in irrigation scheduling.
Enterobacter hormaechei subsp. hoffmannii subsp. nov., Enterobacter hormaechei subsp. xiangfangensis comb. nov., Enterobacter roggenkampii sp. nov., and Enterobacter muelleri is a later heterotypic synonym of Enterobacter asburiae based on computational analysis of sequenced Enterobacter genomes.
Authors: Sutton Granger G. , Brinkac Lauren M. , Clarke Thomas H. , Fouts Derrick E. 
Published: May 2018

Background: The predominant species in clinical Enterobacter isolates is E. hormaechei. Many articles, clinicians, and GenBank submissions misname these strains as E. cloacae. The lack of sequenced type strains or named species/subspecies for some clades in the E. cloacae complex complicate the issue. Methods: The genomes of the type strains for Enterobacter hormaechei subsp. oharae, E. hormaechei subsp. steigerwaltii, and E. xiangfangensis, and two strains from Hoffmann clusters III and IV of the E. cloacae complex were sequenced. These genomes, the E. hormaechei subsp. hormaechei type strain, and other available Enterobacter type strains were analysed in conjunction with all extant Enterobacter genomes in NCBI’s RefSeq using Average Nucleotide Identity (ANI). Results: There were five recognizable subspecies of E. hormaechei: E. hormaechei subsp. hoffmannii subsp. nov., E. hormaechei subsp. xiangfangensis comb. nov., and the three previously known subspecies. One of the strains sequenced from the E. cloacae complex was not a novel E. hormaechei subspecies but rather a member of a clade of a novel species: E. roggenkampii sp. nov.. E. muelleri was determined to be a later heterotypic synonym of E. asburiae which should take precedence. Conclusion: The phylogeny of the Enterobacter genus, particularly the cloacae complex, was re-evaluated based on the type strain genome sequences and all other available Enterobacter genomes in RefSeq.
The Revivals of the Jagiellonian Idea: Political and Normative Contexts
Authors: Pietrzyk-Reeves Dorota 
Published: May 2018

The Revivals of the Jagiellonian Idea: Political and Normative Contexts
The article has two major aims. First, it provides a short analysis of three revivals of the Jagiellonian idea which took place in the nineteenth and the twentieth centuries in different historical and political circumstances. Second, it locates these revivals within the political and normative contexts of the time, and looks at different reasons that explain the persistence of the concept. The article also addresses more general questions, such as the ways that the Jagiellonian idea can be conceptualized, debates over its practicality and usefulness and its lasting presence in Polish national memory. Although there does not seem to be an agreement on the very meaning of the Jagiellonian idea, it certainly has enough normative or symbolic potential to animate strategic policy visions even in the twenty-first century.
Reviews
Authors: Jensen Anita , Cangrand Julie , Marcow-Speiser Vivien , Kossak Mitchell , Kurter Fulya , Weglarz Phil , Lawson Wendy , Levey Amanda 
Published: May 2018

Abstract
Culture, Health & Wellbeing International Conference, Arts & Health South West, Bristol, 19–21 June 2017
Responding to Collective Anxiety and Building Community Resilience: 8th Annual Arts in Healthcare Conference, Lesley University, Cambridge, MA, USA, 28 April 2017
Essentials of Dance Movement Psychotherapy: International Perspectives on Theory, Research and Practice, Helen Payne (ed.) (2017) New York: Routledge, 260 pp., ISBN: 9781138200470, p/bk, $53.95
New Developments in Expressive Arts Therapy: The Play of Poiesis, Ellen Levine and Stephen K. Levine (eds) (2017) London: Jessica Kingsley Publishers, 330 pp., ISBN: 978 1785922473, p/bk, $34.95
Introduction to Art Therapy: Faith in the Product, 3rd ed., Bruce L. Moon (2016) Springfield, IL: Charles C. Thomas, 284 pp., ISBN: 978 0398077976, p/bk, $37.95
‘Living Other Lives’: The impact of senior theatre on older adult well-being
Authors: Fleuriet Jill , Chauvin Trevor 
Published: May 2018

Abstract
In this article, we discuss the impact of a participatory theatre arts programme on the social, emotional and psychological well-being of older adults in San Antonio, Texas. Using a participatory, collaborative approach, we designed an outcomes evaluation for an eight-week Senior Theatre programme sponsored by The Playhouse San Antonio. Pre/post surveys, focal interviews, and participant observation were used to document participant perceptions of self-confidence and self-esteem, emotional intelligence, memory, social engagement and self-rated physical and mental health, and to assess programmatic influences on outcomes. Eleven of the twelve consistently attending students participated in the surveys, six in focal interviews, and eight in the focus group. Closed-ended survey responses were analysed using univariate and bivariate statistics. Field notes, open-ended survey responses and interview transcripts were analysed using discursive textual analysis. Older adults associated their participation in senior theatre with perceived improvements in all outcomes except memory. Results contribute to older adult programming in participatory arts, as well as applied evaluation methodologies that document the impact of creative engagement through the arts on health and well-being, and social science work on health and ageing.
A modified Delphi study on research priorities in cancer, gender and the arts
Authors: Hammond Chad , Thomas Roanne , Saunders Stephanie , Holtslander Lorraine , Hamilton Ryan 
Published: May 2018

Abstract
Men and women diagnosed with cancer may encounter complex changes to gendered roles and expectations within the work environment, families and the community. Creative interventions using the arts could address some of these challenges using person-centred approaches that attend to gender disruptions and negotiations. To identify current research gaps and future priorities in this field, a national expert panel was assembled of seventeen professionals in cancer and gender research, supportive cancer care and artistic practice. During a two-day forum, the panel participated in a modified Delphi process involving two rounds of surveys, a breakout session and panel discussions. At the end of the forum, the panel had identified three diverse programmes of research highlighting key areas at the intersection of cancer, gender and the arts. This process showed both the need for and the promise of interdisciplinary collaborations to identify creative research solutions for gendered challenges during health crises.
The ‘BIG Anxiety Project’: Using the arts to visually explore public experiences and attitudes to anxiety
Authors: Larsen Mark E. , Vaughan Priya , Bennett Jill , Boydell Katherine 
Published: May 2018

Abstract
Anxiety affects everyone, in some intensity, at some time. We report on the ‘BIG Anxiety Project’, a citizen science arts project to explore the public’s experiences and responses to anxiety, which has established a collaboration between visual artists and mental health researchers. A variety of sources of data were used for analysis: visualization and public discussion as part of the project, including from social media, surveys and live polling. Common responses were observed across the data sets, including bodily and physiological responses to anxiety, as well as differences, for example statements of severity versus symbolic expression. Such citizen science arts projects offer the opportunity to engage the public in scientific data collection as well as shaping the research agenda and forming specific research questions.
Heat input and accumulation for ultrashort pulse processing with high average power
Authors: Finger Johannes , Bornschlegel Benedikt , Reininghaus Martin , Dohrn Andreas , Nießen Markus , Gillner Arnold , Poprawe Reinhart 
Published: May 2018

Abstract
Materials processing using ultrashort pulsed laser radiation with pulse durations <10 ps is known to enable very precise processing with negligible thermal load. However, even for the application of picosecond and femtosecond laser radiation, not the full amount of the absorbed energy is converted into ablation products and a distinct fraction of the absorbed energy remains as residual heat in the processed workpiece. For low average power and power densities, this heat is usually not relevant for the processing results and dissipates into the workpiece. In contrast, when higher average powers and repetition rates are applied to increase the throughput and upscale ultrashort pulse processing, this heat input becomes relevant and significantly affects the achieved processing results. In this paper, we outline the relevance of heat input for ultrashort pulse processing, starting with the heat input of a single ultrashort laser pulse. Heat accumulation during ultrashort pulse processing with high repetition rate is discussed as well as heat accumulation for materials processing using pulse bursts. In addition, the relevance of heat accumulation with multiple scanning passes and processing with multiple laser spots is shown.
Analysis of on-surface and in-air movement in handwriting of subjects with Parkinson’s disease and atypical parkinsonism
Authors: Miler Jerkovic Vera , Kojic Vladimir , Dragasevic Miskovic Natasa , Djukic Tijana , Kostic Vladimir S. , Popovic Mirjana B. 
Published: May 2018

Abstract
The purpose of this paper is to emphasize the importance of in-air movement besides on-surface movement for handwriting analysis. The proposed method uses a classification of drawing healthy subjects and subjects with Parkinson’s disease, according to their on-surface and in-air handwriting parameters during their writing on a graphical tablet. Experimental results on real data sets demonstrate that the highest accuracy of subject’s classification was obtained by combining both on-surface and in-air kinematic parameters.