bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graft Failure in Pediatric Patients After Bone–Patellar Tendon–Bone, Hamstring Tendon, or Quadriceps Tendon Autograft ACLR: A Systematic Review and Meta-analysis
Authors: Petit Camryn B. , Hussain Zaamin B. , McPherson April , Petushek Erich J. , Montalvo Alicia M. , White Mia S. , Slone Harris S. , Lamplot Joseph D. , Xerogeanes John W. , Myer Gregory D. 
Published: November 2024

Background: Anterior cruciate ligament (ACL) reinjury risk is high in young athletes, with graft failure rates as high as 23%. The optimal autograft choice to minimize reinjury risk in this population is unclear. Purpose: To compare graft failure rates between bone–patellar tendon–bone (BPTB), hamstring tendon (HT), and quadriceps tendon (QT) autografts in patients aged ≤18 years with a minimum follow-up (FU) of 24 months. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review of the literature between database inception and March 2022 encompassed PubMed/MEDLINE, Cochrane CENTRAL, Embase, and Web of Science Core Collection databases. Studies on autograft ACL reconstruction (ACLR) using HT, QT, or BPTB autograft in patients ≤18 years old with a minimum FU of 2 years were included. Graft failure rates were pooled and estimated using random-effects models via the inverse variance method and logit transformations. Meta-analyses were used to estimate failure rates and pairwise comparisons were conducted by autograft type when appropriate. Results: A total of 24 studies comprising 2299 patients (HT: n = 1237, 44.8% female, 59.1-month mean FU; BPTB: n = 913, 67.3% female, 79.9-month mean FU; QT: n = 149, 36.4% female, 35.3-month mean FU) were included. HT exhibited the highest failure rate at 11.8% (95% CI, 9.0%-15.4%); failure rates for BPTB and QT were 7.9% (95% CI, 6.2%-10.0%) and 2.7% (95% CI, 1.0%-7.5%), respectively. HT had a significantly higher failure rate than both BPTB (Q = 5.01; P = .025) and QT (Q = 7.70; P = .006); BPTB had a significantly higher failure rate than QT (Q = 4.01; P = .045). Male patients were less likely than their female counterparts to experience graft failure after HT ACLR (odds ratio, 0.48; 95% CI, 0.25-0.95). Conclusion: While the HT remains a common choice for ACLR, the current aggregate data indicate that BPTB and QT demonstrated significantly lower failure rates than HT ACLR in adolescent athletes ≤18 years old. The QT demonstrated the lowest failure rate in adolescents but also the lowest proportion of patients represented due to a paucity of published QT data, indicating a need for future studies with larger sample sizes that include QT autografts, reduced risk of bias, and consistent reporting on skeletal maturity and surgical technique to better determine the ideal autograft for active athletic populations ≤18 years old.
Predicting risky driving behavior with classification algorithms: results from a large-scale field-trial and simulator experiment
Authors: Garefalakis Thodoris , Michelaraki Eva , Roussou Stella , Katrakazas Christos , Brijs Tom , Yannis George 
Published: November 2024

AbstractRoad safety is a subject of significant concern and substantially affects individuals across the globe. Thus, real-time, and post-trip interventions have gained significant importance in the past few years. This study aimed to analyze different classification techniques and examine their ability to identify dangerous driving behavior based on a dual-approach study. The analysis was based on the investigation of important risk factors such as average speed, harsh acceleration, harsh braking, headway, overtaking, distraction (i.e., mobile phone use), and fatigue. In order to achieve the objective of this study, data were collected through a driving simulator as well as a naturalistic driving study. To that end, four classification algorithms, namely support vector machines, random forest (RFs), AdaBoost, and multilayer perceptron (MLP) neural networks were implemented and compared. In the simulator experiment, RFs and MLPs emerged as the top-performing models with an accuracy of 84% and 82%, respectively, demonstrating its ability to accurately classify driving behavior in a controlled environment. In the naturalistic driving study, RF and AdaBoost maintained robust performance, with high accuracy (i.e., 75% and 76.76% respectively) and balanced precision and recall. The outcomes of this study could provide essential guidance for practitioners and researchers on choosing models for driving behavior classification tasks.
Infectious keratoconjunctivitis in European bison (Bison bonasus) in Poland: risk factors, epidemiology and anatomopathological changes with analysis of potential role of Thelazia nematodes in the disease development
Authors: Filip-Hutsch Katarzyna , Demiaszkiewicz Aleksander W. , Hutsch Tomasz , Duk Karolina , Klich Daniel , Pyziel Anna M. , Balińska Paulina , Anusz Krzysztof 
Published: November 2024

Abstract
Background
Infectious keratoconjunctivitis (IKC) is a common ocular disease of ruminants worldwide. Recently, an outbreak of infectious keratoconjunctivitis was observed in the European bison in Poland. Hundreds of animals show conjunctival congestion, corneal opacity, and ulceration, leading to total blindness. The present study aimed to examine the ocular changes of European bison and patterns of the disease occurrence with special emphasis on the role of Thelazia nematodes in the development of IKC.

Results
The eyes of 131 European bison, showing ocular signs and clinically healthy, were collected in Poland in 2021 – 2022 and subjected to parasitological and histopathological examination. Histopathology showed varying lesions, including corneal erosions or ulcers, diffuse purulent infiltrates to lymphocytic infiltration in the cornea, and lymphocytic or mixed conjunctivitis with CALT stimulation. The severity of ocular changes was higher in European bison from mountain areas and during the winter season. Two species of Thelazia nematodes – T. skrjabini and T. gulosa have been isolated from eyes. Prevalence of infection reached over 66.4%, and the infection intensity ranged from 1 to 16 nematodes per individual. Although nematodes of the genus Thelazia were prevalent in European bison, their occurrence did not correspond with the severity of ocular changes.

Conclusions
The results of our studies allowed to identify patterns related to the first outbreak of infectious keratoconjunctivitis in European bison. Living in mountain areas and winter season were the most predisposing factors for the development of ocular changes. Despite the high prevalence of Thelazia nematodes in the present study, their role in forming ocular lesions was not confirmed.
Maternal infection of SARS-CoV-2 during the first and second trimesters leads to newborn telomere shortening
Authors: Wang Lina , Zhang Junfeng , Liu Fangfei , Shi Qixiang , Gao Fengchun , Li Junmin , Liu Yanhua , Kong Feng , Xu Dawei 
Published: November 2024

Abstract
Background
Initial telomere length (TL) in newborns is the major determinant for TL in later life while TL in newborn/early-life predicts long-term health and lifespan. It is important to identify key factors that affect telomere homeostasis throughout embryonic development for precision interventions to maintain optimal TL in fetus/prenatal infants. SARS-CoV-2 has caused a widespread global pandemic of COVID-19, but it remains unclear whether maternal SARS-CoV-2 infection impairs prenatal telomere homeostasis.

Methods
We recruited 413 normally delivered newborns whose mothers were either non-infected or infected with SARS-CoV-2 during different trimesters of pregnancy (otherwise healthy). Telomere length (TL) in cord blood (CB) was assessed using qPCR. CB and maternal blood were analyzed for cytokine levels. Placental senescence was determined using senescence-associated β-galactosidase staining.

Results
Control (non-infected maternal) newborn TL was significantly longer than that from maternal infection (1.568 ± 0.340 vs 1.390 ± 0.350, P = 0.005). Such shorter TL was observed only if maternal infection of SARS-CoV-2 occurred in the first and second trimesters of pregnancy (1.261 ± 0.340 and 1.346 ± 0.353, P < 0.0001 and 0.001, respectively). There were no differences in TL between controls and infection at the third trimester (1.568 ± 0.340 vs 1.565 ± 0.329, P > 0.05). Across the first trimester, there was a positive correlation between newborn TL and gestational weeks with maternal infection, suggesting that the earlier maternal infection occurs, the worse effect is taken on fetal telomere homeostasis. Placental senescence coupled with the downregulated expression of telomerase reverse transcriptase was significantly more frequent from the maternal infection at the first trimester. There were no differences in IL-6, C reactive protein and other cytokine levels in CB and maternal serum or placentas.

Conclusions
Maternal SARS-CoV-2 infection at the first and second trimesters leads to significantly shorter TL and earlier infection causes much more severe TL damage. The infection-mediated cell senescence and other histopathological abnormalities result in defective placental function through which fetal telomere homeostasis is impaired. Thus, vaccination against COVID-19 should be done in advance for women who plan pregnancy.
Exploring relationships between conflict intensity, forced displacement, and healthcare attacks: a retrospective analysis from Syria, 2016–2022
Authors: Tarnas Maia C. , Hamze Mohamed , Tajaldin Bachir , Sullivan Richard , Parker Daniel M. , Abbara Aula 
Published: November 2024

Abstract
Introduction
Attacks on healthcare have been committed throughout the Syrian conflict in violation of International Humanitarian Law (IHL), contributing to the devastation of the country’s healthcare system. The conflict has also forcibly displaced over half of Syria’s pre-conflict population, 7.2 million of whom are internally displaced. In this retrospective analysis, we aim to assess the relationships between (1) healthcare attacks and general conflict and (2) healthcare attacks and forced displacement between 2016 and 2022.

Methods
Data on healthcare attacks, conflict events, and displacement were extracted from the Syrian American Medical Society (SAMS), Uppsala Conflict Data Project, and OCHA Türkiye, respectively. The analysis addresses three research questions: the associations between (1) healthcare attacks and conflict events, (2) healthcare attacks and conflict events in the week after an attack on a healthcare facility, and (3) healthcare attacks and forced displacement. For each, we used generalized additive models with a negative binomial distribution that also accounted for spatial and temporal factors.

Results
SAMS recorded a total of 541 attack events, comprising 650 attack rounds over 235 facilities between 2016 and 2022. Conflict events were significantly associated with healthcare attacks in the same week (IRR: 1.14, 95% CI 1.12–1.17), and healthcare attacks in one week were associated with a maximum of 1.44 greater risk (95% CI 1.08–1.91) of conflict events in the following week, even when accounting for general conflict levels in the previous weeks. Healthcare attacks were also significantly associated with increased displacement up to three months following the attacks.

Discussion
We find that healthcare facilities are not avoided during conflict (as obliged under IHL), and that healthcare attacks significantly precede an escalation of general conflict in the same area. Healthcare attacks are also significantly associated with displacement for months following the attacks, even when accounting for conflict levels. Based on these findings, we present a framework outlining one pathway through which healthcare attacks may contribute to larger conflict tactics. Our findings highlight the critical role of healthcare infrastructure in conflict and reaffirm calls to hold perpetrators of these attacks accountable.
Predictors of intradialytic hypotension in critically ill patients undergoing kidney replacement therapy: a systematic review
Authors: Lyrio Rafaella Maria C. , Macedo Etienne , Murugan Raghavan , da Silva Arnaldo A. , Calcagno Tess M. , Sampaio Estevão F. , Sassi Rafael H. , da Hora Passos Rogério 
Published: November 2024

Abstract
Background
This systematic review aims to identify predictors of intradialytic hypotension (IDH) in critically ill patients undergoing kidney replacement therapy (KRT) for acute kidney injury (AKI).

Methods
A comprehensive search of PubMed was conducted from 2002 to April 2024. Studies included critically ill adults undergoing KRT for AKI, excluding pediatric patients, non-critically ill individuals, those with chronic kidney disease, and those not undergoing KRT. The primary outcome was identifying predictive tools for hypotensive episodes during KRT sessions.

Results
The review analyzed data from 8 studies involving 2873 patients. Various machine learning models were assessed for their predictive accuracy. The Extreme Gradient Boosting Machine (XGB) model was the top performer with an area under the receiver operating characteristic curve (AUROC) of 0.828 (95% CI 0.796–0.861), closely followed by the deep neural network (DNN) with an AUROC of 0.822 (95% CI 0.789–0.856). All machine learning models outperformed other predictors. The SOCRATE score, which includes cardiovascular SOFA score, index capillary refill, and lactate level, had an AUROC of 0.79 (95% CI 0.69–0.89, p < 0.0001). Peripheral perfusion index (PPI) and heart rate variability (HRV) showed AUROCs of 0.721 (95% CI 0.547–0.857) and 0.761 (95% CI 0.59–0.887), respectively. Pulmonary vascular permeability index (PVPI) and mechanical ventilation also demonstrated significant diagnostic performance. A PVPI ≥ 1.6 at the onset of intermittent hemodialysis (IHD) sessions predicted IDH associated with preload dependence with a sensitivity of 91% (95% CI 59–100%) and specificity of 53% (95% CI 42–63%).

Conclusion
This systematic review shows how combining predictive models with clinical indicators can forecast IDH in critically ill AKI patients undergoing KRT, with validation in diverse settings needed to improve accuracy and patient care strategies.
The role of nutraceuticals in managing metabolic syndrome: a review of clinical studies
Authors: Olalekan Samuel Oluwadare , Bakare Olalekan Olanrewaju , Okwute Patrick Godwin , Osonuga Ifabunmi Oduyemi , Adeyanju Muinat Moronke , Olalekan Rhoda Oluwaseun 
Published: November 2024

Abstract
Background
Metabolic syndrome (MetS) encompasses a cluster of metabolic disorders including central obesity, elevated triglycerides, low HDL cholesterol, high blood pressure, and elevated fasting glucose. These disorders collectively heighten the risk of cardiovascular disease (CVD), insulin resistance, and type 2 diabetes mellitus (T2DM). With its increasing global prevalence, MetS presents significant public health challenges that necessitate comprehensive management strategies. Traditional treatments primarily involve pharmacological interventions, which are often associated with adverse effects and can lead to patient non-compliance.

Main body
Nutraceuticals represent a promising alternative to conventional treatments for MetS. These compounds, derived from whole foods and dietary supplements, are being investigated for their potential benefits in improving insulin sensitivity, and lipid profiles, reducing inflammation, and addressing various components of MetS. This review critically evaluates clinical studies focused on nutraceuticals and their efficacy in enhancing metabolic health. By examining a range of interventions, the review provides evidence supporting the role of nutraceuticals in managing MetS.

Conclusion
The findings of this review are pertinent to patients, researchers, and medical practitioners. For patients, nutraceuticals offer a potentially safer and more tolerable management option that could improve treatment adherence and quality of life. Researchers will benefit from understanding the mechanisms of action of these comp ounds, which can guide future studies aimed at optimizing their clinical use. Medical practitioners can utilize the insights provided to integrate nutraceuticals into their therapeutic strategies, promoting a more holistic approach to managing MetS and mitigating the burden of related chronic diseases. This comprehensive analysis serves as a foundation for advancing patient care and public health in the context of MetS.
Convergence rate sliding mode control of permanent magnet synchronous motor based on expanded sliding mode observer
Authors: Tian Li , Wei Qingrui , Zheng Qiang , Li Hailong 
Published: November 2024

AbstractThe aim is to address the limitations of conventional sliding mode control for PMSM, namely the problems of sliding mode oscillation, load disturbance, and poor control accuracy. An improved sliding mode control strategy for PMSM is proposed based on the novel convergence rate and extended state observer. Firstly, an integral sliding mode velocity loop controller is designed based on the novel convergence rate to solve the sliding mode vibration problem. The stability of the proposed control strategy is derived by the Lyapunov criterion. Secondly, an extended state observer capable of estimating the disturbance torque is designed for the purpose of disturbance compensation. The disturbance torque estimate is then used as a feed-forward signal for the sliding mode velocity loop controller. A fast second-order sliding mode controller is used for the current loop to avoid the potential introduction of noise and disturbances. The simulation results show that compared to alternative control strategies, the proposed control strategy enables the PMSM to respond effectively to start-up and load disturbances, significantly reduces the sliding mode jitter, and improves both the torque estimation accuracy and the system control accuracy.
Real-World Study on Implementation of Genomic Tests for Advanced Lung Adenocarcinoma in Brazil
Authors: Dienstmann Rodrigo , da Silva Leonard M. , Orpinelli Ramos do Rego Fernanda , Muniz Rodrigues Amanda , Koyama Fernanda Christtanini , Galindo Layla Testa , de Bustamante Fernandes Carolina , de Souza Bruno Batista , Paes Rafael Duarte , Montella Tatiane , de Marchi Pedro , Jeha Araújo Breno , Ferrari Bruno Lemos , Mathias Clarissa , Pereira Emilio , Zalis Mariano Gustavo , Leslin Chesley , Ferreira Carlos Gil 
Published: November 2024

PURPOSE
Tissue inadequacy and operational challenges may limit lung cancer comprehensive biomarker testing. Here, we describe the initial implementation of a tailored tissue molecular journey at Oncoclínicas Precision Medicine Laboratory in Brazil, which includes fast-track (FT) non–next-generation sequencing (NGS) assays combined with a broad NGS panel.

METHODS

From 2021 to 2023, all nonsquamous lung cancer samples eligible for the patient support program “Lung Mapping Consortium” at Oncoclínicas & Co were evaluated using the FT panel (immunohistochemistry for PD-L1 and anaplastic lymphoma kinase [ALK], polymerase chain reaction for
EGFR
and
BRAF
, and fluorescence in situ hybridization for
ROS1
) plus a broad DNA and RNA sequencing panel of 180 genes (custom ARCHER panel).

RESULTS

From 1,272 samples received by the laboratory, 3% had no tissue for any molecular testing, 20% was not eligible for broad NGS panel as per pathologist assessment (tumor purity and quantity), additional 12% did not reach presequencing analytical thresholds (nucleic acid quantity and/or quality), and 3% had postsequencing failure. Most frequent alterations were
KRAS
mutations (28.4%,
KRAS
G12C
9.7%),
EGFR
mutations (23.6%, exon20 insertions 2.9%),
ALK
fusions (6.4%),
MET
exon 14 skipping (4.4%),
ERBB2
mutations (3.4%),
ROS1
fusions (3.1%), and
BRAF
V600E
(1.9%). In 35% of the samples, FT non-NGS tests were the only molecular diagnostics:
EGFR
mutations (14%),
ALK
fusions (4.4%),
ROS1
fusions (1.8%), and
BRAF
V600E
(0.7%). Overall, high PD-L1 expression (≥50%) was found in 12.3%.

CONCLUSION

This study provides data on the molecular epidemiology of lung adenocarcinoma in Brazil, confirming high prevalence of
EGFR
mutations,
ALK
fusions, and
MET
exon 14 skipping alteration. Biomarker detection is largely affected by biospecimen collection and processing, with one third of the patients eligible for non-NGS testing only, which presents reduced coverage and sensitivity for actionable drivers.
Effectiveness of a Cardiovascular Health Electronic Health Record Application for Cancer Survivors in Community Oncology Practice: Results From WF-1804CD
Authors: Weaver Kathryn E. , Dressler Emily V. , Klepin Heidi D. , Lee Simon C. , Wells Brian J. , Smith Sydney , Hundley W. Gregory , Lesser Glenn J. , Nightingale Chandylen L. , Turner Julie C. , Lackey Ian , Heard Kevin , Foraker Randi ,   for the AH-HA Study Team, Weaver Kathryn E. , Foraker Randi , Dressler Emily V. , Wells Brian , Hundley W. Gregory , Klepin Heidi , Payne Philip , Lai Albert , Lee Simon Craddock , Lesser Glenn J. , Carlson Jay W. , Hernandez Marcia L. , Hanna Jenny , Rodgers Heide Alexandra , Varghese Sonia J. , Throckmorton Alyssa D. , Panikkar Rajiv , Ronjon Paula , Lukenbill Joshua , Stroh Ann Louise , Onitilo Adedayo A. , Kulbacki Lindsey W. , Matin Khalid , Hackney Mary Helen 
Published: November 2024

PURPOSE
Guidelines recommend cardiovascular (CV) risk assessment and counseling for cancer survivors. This study evaluated the automated heart-health assessment (AH-HA) clinical decision support tool to promote provider-patient CV health (CVH) discussions in outpatient oncology.

METHODS
The AH-HA trial (WF-1804CD), coordinated by the Wake Forest National Cancer Institute Community Oncology Research Program Research Base, randomized practices to the AH-HA tool or usual care (UC) and enrolled survivors receiving routine care ≥6 months after curative cancer treatment. The tool displayed American Heart Association Life's Simple 7 CVH factors (BMI, physical activity, diet, smoking status, blood pressure, cholesterol, and glucose), populated from the electronic health record (EHR), alongside cancer treatments received with cardiotoxic potential. The primary end point was survivor-reported discussion of nonideal or missing CVH factors. A mixed-effects logistic regression model assessed the effect of AH-HA on CVH discussions, adjusting for practice.

RESULTS

Five UC and four AH-HA practices enrolled 645 survivors (82% breast, 8% endometrial, 5% colorectal, and 5% lymphoma, prostate, or multiple types) from October 1, 2020, to February 28, 2023. Most survivors were female (96%; 84% White/non-Hispanic, 8% Black; 3% Hispanic). Nearly all survivors (98%) in AH-HA practices reported a discussion for ≥1 nonideal or missing CVH factor compared with 55% in UC (
P
< .001). The average number of survivor-reported factors discussed was higher in AH-HA compared with UC (mean, 4.06
v
1.27;
P
< .001), as were EHR-documented discussions (3.83
v
0.77;
P
= .03). Survivors in AH-HA practices were also significantly more likely to report a recommendation to see a primary care provider (39%) compared with UC practices (25%,
P
= .02). Reported recommendations to see a cardiologist were low (approximately 6%) and did not differ between groups.

CONCLUSION
The AH-HA tool was effective at promoting CVH discussions during routine follow-up care for survivors and recommendations to consult primary care.