bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of key genes related to dexamethasone-resistance in acute lymphoblastic leukemia
Authors: Chen Qiuni , Chen Shixin , Shi Yuye , Tao Shandong , Chen Wei , Wang Chunling , Yu Liang 
Published: June 2018

AbstractDrug resistance is the main cause of poor chemotherapy response in acute leukemia. Despite the extensive use of dexamethasone(DEX) in the treatment of acute lymphoblastic leukemia for many years, the mechanisms of dexamethasone – resistance has not been fully understood. We choose GSE94302 from GEO database aiming to identify key genes that contribute to the DEX resistance in acute lymphoblastic leukemia. Differentially expressed gene(DEGs) are selected by using GEO2R tools. A total of 837 DEGs were picked out, including 472 up-regulated and 365 down-regulated DEGs. All the DEGs were underwent gene ontology(GO) analysis and Kyoto Encyclopedia of Gene and Genome(KEGG) pathway analysis. In addition, the DEGs-encoded protein-protein interaction (PPI) was screened by using Cytoscape and Search Tool for the Retrieval of Interacting Genes(STRING). Total 20 genes were found as key genes related to DEX resistance with high degree of connectivity, includingCDK1, PCNA, CCNB1, MYC, KPNA2, AURKA, NDC80, HSPA4, KIF11, UBE2C, PIK3CG, CD44, CD19, STAT1, DDX41, LYN, BCR, CD48, JAK1andITGB1. They could be used as biomarkers to identify the DEX-resistant acute lymphoblastic leukemia.
Attentional modulation of orthographic neighborhood effects during reading: Evidence from event-related brain potentials in a psychological refractory period paradigm
Authors: Rabovsky Milena , Conrad Markus , Álvarez Carlos J. , Paschke-Goldt Jörg , Sommer Werner 
Published: June 2018

AbstractIt is often assumed that word reading proceeds automatically. Here, we tested this assumption by recording event-related potentials during a psychological refractory period (PRP) paradigm, requiring lexical decisions about written words. Specifically, we selected words differing in their orthographic neighborhood size – the number of words that can be obtained from a target by exchanging a single letter – and investigated how influences of this variable depend on the availability of central attention. As expected, when attentional resources for lexical decisions were unconstrained, words with many orthographic neighbors elicited larger N400 amplitudes than those with few neighbors. However, under conditions of high temporal overlap with a high priority primary task, the N400 effect disappeared. This finding indicates strong attentional influences on the incidental processing of orthographic neighbors during word reading, providing novel evidence against the automaticity of processes involved in word reading. Furthermore, in conjunction with the observation of an underadditive interaction between stimulus onset asynchrony (SOA) and orthographic neighborhood size in lexical decision performance, commonly taken to indicate automaticity, our results raise issues concerning the standard logic of cognitive slack in the PRP paradigm.
Warning systems as social processes for Bangladesh cyclones
Authors: Kelman Ilan , Ahmed Bayes , Esraz-Ul-Zannat Md , Saroar Md Mustafa , Fordham Maureen , Shamsudduha Mohammad 
Published: June 2018

Purpose
The purpose of this paper is to connect the theoretical idea of warning systems as social processes with empirical data of people’s perceptions of and actions for warning for cyclones in Bangladesh.

Design/methodology/approach
A case study approach is used in two villages of Khulna district in southwest Bangladesh: Kalabogi and Kamarkhola. In total, 60 households in each village were surveyed with structured questionnaires regarding how they receive their cyclone warning information as well as their experiences of warnings for Cyclone Sidr in 2007 and Cyclone Aila in 2009.

Findings
People in the two villages had a high rate of receiving cyclone warnings and accepted them as being credible. They also experienced high impacts from the cyclones. Yet evacuation rates to cyclone shelters were low. They did not believe that significant cyclone damage would affect them and they also highlighted the difficulty of getting to cyclone shelters due to poor roads, leading them to prefer other evacuation options which were implemented if needed.

Originality/value
Theoretical constructs of warning systems, such as the First Mile and late warning, are rarely examined empirically according to people’s perceptions of warnings. The case study villages have not before been researched with respect to warning systems. The findings provide empirical evidence for long-established principles of warning systems as social processes, usually involving but not relying on technical components.
Managerial strategies to promote employee brand consistent behavior
Authors: Quaratino Luca , Mazzei Alessandra 
Published: June 2018

PurposeThe purpose of this paper is to examine the role of managerial strategies in promoting employee brand consistent behavior. Using a recently developed holistic model of behavioral branding, that suggests that a wide array of managerial strategies affects the branding process, this study addresses two specific questions: what communication strategies, in the opinion of managers, sustain employee brand consistent behavior? And what are the most important factors, both contextual and related to their cognitive-emotional states, that employees think affect their brand ambassadorship behavior?Design/methodology/approachA long-term research program was conducted based on a multiple methods research strategy to answer the two questions. The choice of different methods was mainly based on the specific characteristics of the two targets: communication managers and employees. The first one based on interviews with 32 managers, and the second one based on a case study of a single company.FindingsThe results show that enablement-oriented strategies are more effective than communication-oriented strategies in sustaining employee brand builder roles. Weak employee commitment, unsatisfactory external communication, and low levels of motivation are strong contextual factors inhibiting employee attitudes to brand ambassadorship, one of the most relevant employee brand consistent behaviors in competitive contexts. The main practical implication is that companies should engage employees as brand ambassadors, not by means of prescriptions of in-role behavior, but enablement strategies leading to authentic and voluntary behaviors; besides, that companies should put a significant effort in “preparing the soil,” i.e. investing in enhancing employee commitment, level of motivation, and understanding/alignment with the external communication.Practical implicationsThe main practical implication is that companies should engage employees as brand ambassadors not by means of in-role behavior prescriptions rather by means of enablement strategies leading to authentic and voluntary behaviors. Besides, managers should invest significant efforts in enhancing employee motivation, commitment, and understanding/alignment to external communication as they represent key factors in sustaining brand ambassadorship behaviors.Originality/valueThe values of the study lies in having highlighted the crucial role of enablement-oriented strategies, and the relevance of specific contextual variables affecting the attitude of employee toward brand consistent behaviors.
Big Five personality traits in simulated negotiation settings
Authors: Falcão Pedro Fontes , Saraiva Manuel , Santos Eduardo , Cunha Miguel Pina e 
Published: June 2018

Purpose
After a hiatus in the research on individual differences in negotiation, there has been a surge of renewed interest in recent years followed by several new findings. The purpose of this paper is to explore the effects that personality, as structured by the five-factor model, have over negotiation behavior and decision making in order to create new knowledge and prescribe advice to negotiators.

Design/methodology/approach
This study replicates observations from earlier studies but with the innovation of using a different methodology, as data from a sample of volunteer participants were collected in regard to their personality and behavior during two computerized negotiation simulations, one with the potential for joint gains and the other following a more traditional bargaining scenario.

Findings
Significant results for both settings were found, with the personality dimensions of agreeableness, conscientiousness, and extraversion systematically reoccurring as the most statistically relevant, although expressing different roles according to the type of negotiation and measure being registered. The findings thus suggest a multidimensional relationship between personality and situational variables in which specific traits can either become liabilities or assets depending upon whether the potential for value creation is present or not.

Originality/value
The new findings on the impacts of personality traits on both distributive and integrative negotiations allow negotiators to improve their performance and to adapt to specific distributive or integrative negotiation situations.
Security questions education: exploring gamified features and functionalities
Authors: Micallef Nicholas , Arachchilage Nalin Asanka Gamagedara 
Published: June 2018

PurposeSecurity questions are one of the techniques used to recover forgotten passwords. However, security questions have both security and memorability limitations. To limit their security vulnerabilities, stronger answers need to be used. As serious games can motivate users to change their security behaviour, the purpose of this paper is to explore the features and functionalities that users would require in a serious game that educates them to provide stronger answers to security questions.Design/methodology/approachA lab study was conducted to collect users’ feedback on the desired game features and functionalities. In Stage 1, participants selected security questions/answers. In Stage 2, participants played a game and evaluated the usability and the provided features.FindingsThe main findings reveal that most participants found the current features and functionalities to be desirable; socially oriented functionalities (e.g. getting help from other players) did not seem desirable because users feared that their acquaintances could gain access to their security questions.Originality/valueThis research recommends that designers of serious games for security education should: use intrinsic rewards to motivate users to have a better learning experience; provide easier challenges during the training period and provide harder challenges only when the game determines that the users learned to play the game; and design their games for mobile devices because even users who usually do not play games would play a security education game on a mobile device.
Identifying and predicting the factors affecting end-users’ risk-taking behavior
Authors: Alohali Manal , Clarke Nathan , Li Fudong , Furnell Steven 
Published: June 2018

Purpose
The end-user has frequently been identified as the weakest link; however, motivated by the fact that different users react differently to the same stimuli, identifying the reasons behind variations in security behavior and why certain users could be “at risk” more than others is a step toward protecting and defending users against security attacks. This paper aims to explore the effect of personality trait variations (through the Big Five Inventory [BFI]) on users’ risk level of their intended security behaviors. In addition, age, gender, service usage and information technology (IT) proficiency are analyzed to identify what role and impact they have on behavior.

Design/methodology/approach
The authors developed a quantitative-oriented survey that was implemented online. The bi-variate Pearson two-tailed correlation was used to analyze survey responses.

Findings
The results obtained by analyzing 538 survey responses suggest that personality traits do play a significant role in affecting users’ security behavior risk levels. Furthermore, the results suggest that BFI score of a trait has a significant effect as users’ online personality is linked to their offline personality, especially in the conscientiousness personality trait. Additionally, this effect was stronger when personality was correlated with the factors of IT proficiency, gender, age and online activity.

Originality/value
The contributions of this paper are two-fold. First, with the aid of a large population sample, end-users’ security practice is assessed from multiple domains, and relationships were found between end-users’ risk-taking behavior and nine user-centric factors. Second, based upon these findings, the predictive ability for these user-centric factors were evaluated to determine the level of risk a user is subject to from an individual behavior perspective. Of 28 behaviors, 11 were found to have a 60 per cent or greater predictive ability, with the highest classification of 92 per cent for several behaviors. This provides a basis for organizations to use behavioral intent alongside personality traits and demographics to understand and, therefore, manage the human aspects of risk.
In their own words: employee attitudes towards information security
Authors: Ashenden Debi 
Published: June 2018

Purpose
The purpose of this study is to uncover employee attitudes towards information security and to address the issue of social acceptability bias in information security research.

Design/methodology/approach
The study used personal construct psychology and repertory grids as the foundation for the study in a mixed-methods design. Data collection consisted of 11 in-depth interviews followed by a survey with 115 employee responses. The data from the interviews informed the design of the survey.

Findings
The results of the interviews identified a number of themes around individual responsibility for information security and the ability of individuals to contribute to information security. The survey demonstrated that those employees who thought the that organisation was driven by the need to protect information also thought that the risks were overstated and that their colleagues were overly cautious. Conversely, employees who thought that the organisation was driven by the need to optimise its use of information felt that the security risks were justified and that colleagues took too many risks.

Research limitations/implications
The survey findings were not statistically significant, but by breaking the survey results down further across business areas, it was possible to see differences within groups of individuals within the organisation.

Originality/value
The literature review highlights the issue of social acceptability bias and the problem of uncovering weakly held attitudes. In this study, the use of repertory grids offers a way of addressing these issues.
An analysis of medical waste management practices in the health care sector in Colombo
Authors: Gunawardana Kennedy Degaulle 
Published: June 2018

Purpose
The purpose of this paper is to identify the type of waste generation and the management of waste in order to reduce pollution in the health care sector with special reference to Colombo, Sri Lanka. The paper further aims to determine the relationship between top management and staff attitudes toward waste management and to identify the level of technology used in medical waste management in various types of health care organizations.

Design/methodology/approach
A survey questionnaire was developed using the designed conceptual framework to achieve the objectives of the study.

Findings
The study identifies that, though governments provide legislations and regulatory support, organizations of any size must have a positive attitude, awareness, capability and technology to initiate improvements for waste management processes and be prepared to adapt to new trends. Developing positive attitudes and improved knowledge on changes in waste management technology will assist in encouraging organizations to invest in this area.

Research limitations/implications
The scope of this project is limited to private health care institutions in the Colombo district in Sri Lanka from where data were gathered.

Originality/value
Health care center waste management is a relatively new discipline in the Sri Lankan health sector. This study provides an opportunity for management to identify the level of waste generated by health care institutions and the methods followed for the disposal of waste. Environmental groups can gain benefit through this project, since they can identify whether the private institutes in the health care sector are following world-accepted methods in disposing of waste.
The Labour Market Effects of ‘Working for Families’ In New Zealand
Authors: Creedy John , Mercante Joseph , Mok Penny 
Published: June 2018

AbstractThis article examines, using a behavioural microsimulation model for New Zealand, the impact of the major package of welfare reforms collectively referred to as ‘Working for Families’ (WfF). These reforms were announced in May 2004 and involved a phased introduction of changes, with annual modifications from October 2004 until April 2007. Concentrating on welfare payments for families with dependent children, this remains a cornerstone of the New Zealand welfare system. The simulation takes a backward‐looking perspective, by comparing labour supply under the 2008 database and tax structure with that obtained using the 2008 data and 2004 tax structure (suitably adjusted for inflation).
Are Founder CEOs Effective Innovators?
Authors: Kim Jonghwan (Simon) , Koo KwangJoo (KJ) 
Published: June 2018

AbstractThis paper investigates the effectiveness of founder CEOs on firm innovation. We examine our research question using the number of patent citations as a proxy for firm innovation and a novel dataset of founder CEOs in S&P 1,500 firms over a 15‐year period from 1994 to 2008. Our main results show that a founder CEO is associated with an increase in citations, suggesting that founder CEOs are more effective in stimulating innovation compared to professional CEOs. Overall, these findings support the argument that a founder CEO plays an important role in facilitating firm innovation through more risk‐taking.
Accessory lacrimal gland tumours of the eye region
Authors: Mulay Kaustubh , Rasmussen Peter K. , Aggarwal Ekta , Honavar Santosh G. , Heegaard Steffen 
Published: June 2018

AbstractPurposeTumours of the accessory lacrimal glands (ALGs) are rare and need to be differentiated from other tumours involving the eyelids and caruncle. We report on a consecutive series of patients with ALG tumours and describe the clinical characteristics.MethodsA retrospective case series including all patients who were operated for ALG tumours at two different centres.ResultsThe study included 27 patients diagnosed with ALG tumours. Mean age at presentation was 55.9 years (range, 24–81 years; median, 56 years). Overall, a slight male preponderance was observed (M:F = 1.4:1). Histologically, pleomorphic adenoma was the commonest diagnosis (24 of 27; 88.9%), followed by adenoid cystic carcinoma (2 of 27; 7.4%) and oncocytoma (one of 27; 3.7%). A complete surgical excision was curative in all patients.ConclusionAccessory lacrimal gland (ALG) tumours are rare and may therefore pose diagnostic difficulties for clinicians. Histopathological examination of these tumours is the cornerstone of the diagnostic evaluation. Complete surgical excision is the treatment of choice in these tumours.
Experiences of Reframing during Self‐Directed Weight Loss and Weight Loss Maintenance: Systematic Review of Qualitative Studies
Authors: Hartmann‐Boyce Jamie , Nourse Rebecca , Boylan Anne‐Marie , Jebb Susan A. , Aveyard Paul 
Published: June 2018

BackgroundReframing means changing the way that a person thinks or feels about a weight loss attempt or weight loss maintenance to enhance its experience or facilitate its success. Although participants have described this, it has not been explored in the academic literature. Here, we set out to systematically review qualitative studies to examine the ways in which people use and experience reframing in self‐directed weight loss.MethodsSeven electronic databases were searched to January 2017 for qualitative studies of adults with overweight or obesity attempting to lose weight or maintain weight loss through self‐directed behavior change. Studies must have contained some information pertinent to reframing. Thematic synthesis was used to identify descriptive and analytical themes from the available data.ResultsWe included 23 studies, representing 723 participants. No study focused specifically on reframing. Most studies involved people who had tried to lose weight previously. In the most common examples of reframing, participants spoke of construing previous weight management attempts as “dieting”, whereas in current attempts they used reframing to move away from this concept. Participants spoke of finding reframing helpful because it removed the sense of depriving themselves and instead allowed them to construe the food choices as healthful. Likewise, the language of dieting created a sense of temporary effort, while construing this as a way of life allowed continuation of conscious control over energy balance without the feeling of undue effort. In some cases, these changes were bolstered by change in self‐identity.ConclusionsSome people construe deliberate weight loss as a form of deprivation and cognitively reframe to avoid the negative emotions this creates and to prevent relapse. Reframing the dietary regimen as about healthy eating and a new way of life made weight control seem less burdensome for these participants and they felt able to maintain their efforts.
Current and Future Treatments for Persistent Pulmonary Hypertension in the Newborn
Authors: Pedersen Jonas , Hedegaard Elise R. , Simonsen Ulf , Krüger Marcus , Infanger Manfred , Grimm Daniela 
Published: June 2018

AbstractPersistent pulmonary hypertension in newborn (PPHN) is a serious and possibly fatal syndrome characterized by sustained foetal elevation of pulmonary vascular resistance at birth. PPHN may manifest secondary to other conditions as meconium aspiration syndrome, infection and congenital diaphragmatic hernia. This MiniReview provides the reader with an overview of current and future treatment options for patients with PPHN without congenital diaphragmatic hernia. The study is based on systematic searches in the databases PubMed and Cochrane Library and registered studies on Clinicaltrials.gov investigating PPHN. Inhaled nitric oxide (iNO) is well documented for treatment of PPHN, but 30% fail to respond to iNO. Other current treatment options could be sildenafil, milrinone, prostaglandin analogues and bosentan. There are several ongoing trials with sildenafil, but evidence is lacking for the other treatments and/or for the combination with iNO. Currently, there is no evidence for effect in PPHN of other treatments, for example tadalafil, macitentan, ambrisentan, riociguat and selexipag used for pulmonary arterial hypertension in adults. Experimental studies in animal models for PPHN suggest effect of a series of approaches including recombinant human superoxide dismutase, L‐citrulline, Rho‐kinase inhibitors and peroxisome proliferator‐activated receptor‐γ agonists. We conclude that iNO is the most investigated and the only approved pulmonary vasodilator for infants with PPHN. In the iNO non‐responders, sildenafil currently seems to be the best alternative either alone or in combination with iNO. Systematic and larger clinical studies are required for testing the other potential treatments of PPHN.