bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of supracrestal tissue attachment thickness on radiographic bone level around dental implants: A systematic review and meta‐analysis
Authors: Díaz‐Sánchez María , Soto‐Peñaloza David , Peñarrocha‐Oltra David , Peñarrocha‐Diago María 
Published: June 2019

AbstractThe present systematic review and meta‐analysis was carried out to determine the extent to which supracrestal tissue attachment (STA) thickness affects marginal bone loss (MBL) around dental implants. An electronic search was conducted in PubMed (MEDLINE), EMBASE, and complementary sources covering the period up to June 2018. The studies were meta‐analyzed based on implant position with respect to the alveolar bone crest (crestal/supracrestal). The MBL values were categorized according to STA width (thick/thin). Of the 1062 eligible titles, nine articles were included in the review. The implants were positioned crestal or supracrestal with respect to the alveolar ridge. The difference between (thin/thick) STA was statistically significant among analytical subsets in terms of lesser MBL (crestal‐positioned: weighted mean difference [WMD] = 0.52, 95% CI [0.03‐1.01]; P = 0.036; supracrestal‐positioned: WMD = 1.26; 95% CI [1.12‐1.39]; P = 0.00; pooled analysis: WMD = 0.73; 95% CI [0.033‐1.13]; P < 0.01). Implant positioning and patient age showed statistical significance in the meta‐regression analysis. The heterogeneity explained by age was R2 = 39.8%. Despite its limitations, the present study demonstrates that implants with thin STA result in greater MBL. There is moderate certainty of the evidence for a large effect of MBL prevention “in favor” of a thick STA environment in crestal‐positioned implants and the pooled analysis, but lesser certainty when only supracrestal‐positioned implants are considered. No trials studying this topic in subcrestal‐positioned implants were found.
Deciphering the conditions of tochilinite and cronstedtite formation in CM chondrites from low temperature hydrothermal experiments
Authors: Vacher Lionel G. , Truche Laurent , Faure François , Tissandier Laurent , Mosser‐Ruck Régine , Marrocchi Yves 
Published: June 2019

AbstractTochilinite/cronstedtite intergrowths are commonly observed as alteration products in CM chondrite matrices, but the conditions under which they formed are still largely underconstrained due to their scarcity in terrestrial environments. Here, we report low temperature (80 °C) anoxic hydrothermal experiments using starting assemblages similar to the constituents of the matrices of the most pristine CM chondrite and S‐rich and S‐free fluids. Cronstedtite crystals formed only in S‐free experiments under circumneutral conditions with the highest Fe/Si ratios. Fe‐rich tochilinite with chemical and structural characteristics similar to chondritic tochilinite was observed in S‐bearing experiments. We observed a positive correlation between the Mg content in the hydroxide layer of synthetic tochilinite and temperature, suggesting that the composition of tochilinite is a proxy for the alteration temperature in CM chondrites. Using this relation, we estimate the mean precipitation temperatures of tochilinite to be 120–160 °C for CM chondrites. Given the different temperature ranges of tochilinite and cronstedtite in our experiments, we propose that Fe‐rich tochilinite crystals resulted from the alteration of metal beads under S‐bearing alkaline conditions at T = 120–160 °C followed by cronstedtite crystals formed by the reaction of matrix amorphous silicates, metal beads, and water at a low temperature (50–120 °C).
Incidence and outcomes of systemic infections in patients with leadless pacemakers: Data from the Micra IDE study
Authors: El‐Chami Mikhael F. , Soejima Kyoko , Piccini Jonathan P. , Reynolds Dwight , Ritter Philippe , Okabe Toshimasa , Friedman Paul A. , Cha Yong‐Mei , Stromberg Kurt , Holbrook Reece , Fagan Dedra H. , Roberts Paul R. 
Published: June 2019

AbstractBackgroundThe Micra clinical trials have enrolled more than 2500 patients without any reported device‐related infections that required removal during follow‐up. Leadless pacemakers might be more resistant to bacterial seeding due to smaller surface area and a greater tendency for encapsulation.ObjectiveTo analyze the incidence and outcomes of serious infectious events (SIEs: bacteremia or endocarditis) that developed during follow‐up in patients with history of Micra leadless pacemaker implantation.MethodsSIE and outcomes were characterized based upon adverse event reports. Among 720 patients implanted with Micra in the investigational device exemption trial, we identified 16 patients who had documented 21 SIEs during follow‐up.ResultsAmong patients with SIEs, mean age was 71.9 ± 11.7 years. SIEs occurred at a mean 4.8 ± 4.5 months after implant and patients were followed for 13.1 ± 9.1 months after documentation of SIE. All events were adjudicated as unrelated to the Micra device or procedure. Bacteremia was documented to be related to a gram‐positive organism in 13 events (seven Staphylococcus, three Streptococcus, two Enterococcus, and one uncharacterized gram‐positive bacteria), and gram‐negative organisms in three events. In five events, the type of organism was not characterized (two patients with endocarditis). No persistent cases of bacteremia after antibiotic cessation were seen over the duration of follow‐upConclusionIn this small series of Micra patients who developed SIEs postimplant, the occurrence of bacteremia and/or endocarditis did not appear to lead to persistent bacteremia off antibiotics; most events resolved with antibiotic treatment.
The association between interpregnancy interval and severe maternal morbidities using revised national birth certificate data: A probabilistic bias analysis
Authors: De Silva Dane A. , Thoma Marie E. 
Published: June 2019

AbstractBackgroundSevere maternal morbidity continues to be on the rise in the US. Short birth spacing is a modifiable risk factor associated with maternal morbidity, yet few studies have examined this association, possibly due to few available data sources to examine these rare events.ObjectiveTo examine the association between interpregnancy interval (IPI) and severe maternal morbidity using near‐national birth certificate data and account for known under‐reporting using probabilistic bias analysis.MethodsWe used revised 2014‐2017 birth certificate data, restricting to resident women with a non–first‐born singleton birth. We examined the following: (a) maternal blood transfusion, (b) admission to intensive care unit (ICU), (c) uterine rupture (among women with a prior caesarean delivery) and (d) third‐ or fourth‐degree perineal laceration (among vaginal deliveries) by IPI categories (<6, 6‐11, 12‐17, 18‐23, 24‐59 and 60+ months). Risk ratios and 95% confidence intervals were estimated using log‐binomial regression, adjusting for select maternal characteristics. Probabilistic bias analyses were performed.ResultsCompared with IPI 18 to 23 months, adjusted models revealed that the risk of maternal transfusion followed a U‐shaped curve with IPI, while risk of ICU admission and perineal laceration increased with longer IPI. Risk of uterine rupture was highest among IPI <6 months. With the exception of maternal transfusion, these findings persisted regardless of the extent or type of misclassification examined in bias analyses.ConclusionsAssociations between IPI and maternal morbidity varied by outcome, even after adjusting for misclassification of SMM. Differences across maternal health outcomes should be considered when counselling and making recommendations regarding optimal birth spacing.
Comparative biochemical profiles, production and reproduction status of the post‐partum dairy cows with and without purulent vaginal discharge
Authors: Paiano Renan B. , Gonçalves Camila G. P. , Mendes João P. G. , Bonilla Jeannine , Birgel Daniela B. , Birgel Junior Eduardo H. 
Published: June 2019

AbstractPurulent vaginal discharge (PVD) is a prevalent uterine disease of dairy cows during the puerperium that affects the milk production and affects the profitability of farms. The objectives of this study were to evaluate the biochemical profile, the body condition score, the milk production of cows with PVD and the effects PVD on reproductive performance. A total of 338 Holstein dairy cows aged from 3 to 5 years, from three commercial dairy farms, from Brazil, were used. Blood samples were collected within 25 ± 3 days post‐partum from Holstein dairy cows without PVD (control cows, n = 242) and cows with PVD (n = 96), based on scoring of the vaginal discharge. The body condition score and milk production were recorded on the day of sampling. The biochemical profile encompassed albumin, urea, gamma‐glutamyl transferase, calcium, fibrinogen and cholesterol concentrations. The number of services per pregnancy was lower (p < 0.01), and the number of days until first insemination and the median time to pregnancy were higher in cows with PVD (p < 0.01) when compared with control cows. Milk production and body condition score were lower (p < 0.01) in cows with PVD than in control group. Cows with PVD had lower (p < 0.05) serum albumin, urea, calcium and cholesterol concentrations, and higher serum gamma‐glutamyl transferase activity and fibrinogen concentration than cows without PVD. Our results show that cows with PVD have changes in the biochemical profile and negative effects on production and reproduction performance.
A Multisite Health System Survey to Assess Organizational Context to Support Evidence‐Based Practice
Authors: Pittman Joyce , Cohee Andrea , Storey Susan , LaMothe Julie , Gilbert Jason , Bakoyannis Giorgos , Ofner Susan , Newhouse Robin 
Published: June 2019

AbstractBackgroundImplementation and sustainability of a culture of evidence‐based practice (EBP) require a systematic approach. A baseline assessment of the organizational context can inform implementation efforts.AimsTo examine organizational hospital context and provider characteristics associated with EBP readiness and to describe EBP context across hospitals.MethodsA nonexperimental descriptive correlational design was used to conduct a web‐based survey of direct‐care registered nurses (N = 701) and nurse managers (N = 94) across a large Midwestern multisite healthcare system using the Alberta Context Tool (ACT).ResultsMany significant relationships existed among nurse characteristics and ACT domains, including age (lower age had higher Leadership, Evaluation, and Formal Interactions), education (graduate education had lower Social Capital than a bachelor's or associate degree), role (direct‐care nurses had lower Culture than managers and lower Social Capital), and work status (full‐time employees had lower Evaluation and Social Capital). EBP context across type of hospitals is similar, with marginal differences in Social Capital and Organizational Slack (higher in critical access hospitals).Linking Evidence to ActionAssessing organizational context to support EBP is the first step in developing and enhancing a sustainable culture of inquiry. The ACT has been tested across countries, settings, and healthcare disciplines to measure perception of readiness of the practice environment toward EBP. Optimal organizational context is essential to support EBP and sustain the use of evidence in professional nursing practice. Nursing leaders can use baseline assessment information to identify strengths and opportunities to enhance EBP implementation. Enhancing organizational context across nurse characteristics (e.g., age, role, and work status) to acknowledge nurses’ contributions, balance nurses’ personal and work life, enhance connectedness, and support work culture is beneficial. Fostering development of Social Capital in nurses is needed to influence EBP readiness. A systematic and standardized approach to foster EBP across health systems is key to successful implementation.
Reducing radiation exposure during atrial fibrillation ablation using lectures to promote awareness
Authors: Miwa Yosuke , Ueda Akiko , Komeda Michitsugu , Takeuchi Shinsuke , Nagaoka Mika , Momose Yuichi , Nonoguchi Noriko , Hoshida Kyoko , Enomoto Mutsumi , Togashi Ikuko , Maeda Akiko , Hagiwara Yo , Sato Toshiaki , Soejima Kyoko 
Published: June 2019

ObjectiveRecently, concern has increased regarding the hazards of radiation exposure in patients and laboratory staff. Since the numbers of complex catheter ablations (CA) performed, duration of procedure times, and need for multiple sessions have increased, radiation exposure during each session needs to be minimised. Our study aimed to assess the impact of awareness on radiation exposure during CA for atrial fibrillation (AF).MethodsMini-course lectures was delivered to the physicians and staff in the electrophysiology division. Its effect on the fluoroscopic time and radiation dose during AF ablation before (Group I, n=70), shortly after (Group II: n=70) and remotely after the mini-lecture (Group III, n=70) were evaluated. Patient demographics, preoperative testing and procedural parameters were collected.ResultsThe fluoroscopic time significantly reduced after the lecture (Group I and II: 25.1±10.0 and 15.1±7.3 min, respectively (p<0.0001)), and remained so in Group III (13.0±5.4 min), despite the increase in the number of persistent AFs. The radiation dose also significantly reduced (Groups I, II, III: 295.0±263.0, 109.6±103.5 and 110.1±89.6 mGy, respectively (p<0.0001)).ConclusionAwareness on radiation exposure led to a significant reduction in fluoroscopic time and radiation dose during CA for AF, the effect of which persisted even to remote periods following the procedure.
Analysis of the spatiotemporal correlation between vegetation pattern and human activity intensity in Yancheng coastal wetland, China
Authors: Zang Zheng , Zou Xinqing , Song Qiaochu , Yao Yulong 
Published: June 2019

Abstract
Remote sensing images were used to reproduce the changes in wetland vegetation since 1987, and the potential impact of policy changes and human activities on vegetation restoration and biodiversity conservation in coastal wetlands was explored based on the landscape pattern index and the human disturbance index (HDI). The results showed that the vegetation displayed a zonal distribution pattern in which, perpendicular to the coastline early in the study period, the vegetation type changed from coastal wetland to bare mud flat with Spartina alterniflora, Suaeda glauca, and Phragmites australis as well as to constructed wetlands dominated by rice. Under the influence of human activities, the number of patches (NP) and mean nearest-neighbor distance (MNN) between patches gradually increased during the study period, while the mean patch size gradually decreased. The patch density increased from 179 (1987) to 296 patches per ha (2013). Additionally, human activity in the study area intensified. The HDI increased from 0.353 (1987) to 0.471 (1987) and showed positive correlations (R2 > 80%, p < 0.01) with NP and MNN. Human activity, such as changes in land use, resulted in more fragmented vegetation patterns, and the nonzonal (intrazonal) distribution of the vegetation became more obvious in coastal wetlands.
Measuring Higgs self-couplings in the presence of V V H and V V HH at the ILC
Authors: Kumar Satendra , Poulose Poulose , Rahaman Rafiqul , Singh Ritesh K. 
Published: June 2019

The recent discovery of a Higgs boson at LHC, while establishing the Higgs mechanism as the way of electroweak symmetry breaking, started an era of precision measurements involving the Higgs boson. In an effective Lagrangian framework, we consider the [Formula: see text] process, at an ILC running at a center-of-mass energy of 500 GeV to investigate the effect of the [Formula: see text] and [Formula: see text] couplings on the sensitivity of [Formula: see text] coupling on this process. Our results show that the sensitivity of the trilinear Higgs self-couplings on this process has somewhat strong dependence on the Higgs-gauge boson couplings. Single- and two-parameter reaches of ILC with integrated luminosity of 1000 fb[Formula: see text] are obtained on all the effective couplings indicating how these limits are affected by the presence of anomalous [Formula: see text] and [Formula: see text] couplings. The kinematic distributions studied to understand the effect of the anomalous couplings, again, show strong influence of [Formula: see text]–[Formula: see text] couplings on the dependence of these distributions on [Formula: see text] coupling. Similar results are indicated in the case of the process, [Formula: see text], considered at a center-of-mass energy of 2 TeV, where the cross-section is large enough. The effect of [Formula: see text] and [Formula: see text] couplings on the sensitivity of [Formula: see text] coupling is clearly established through our analyses in this process.
CD71+ Population Enriched by HPV-E6 Protein Promotes Cancer Aggressiveness and Radioresistance in Cervical Cancer Cells
Authors: Leung Thomas Ho-Yin , Tang Hermit Wai-Man , Siu Michelle Kwan-Yee , Chan David Wai , Chan Karen Kar-Loen , Cheung Annie Nga-Yin , Ngan Hextan Yuen-Sheung 
Published: June 2019

Abstract

A subpopulation of cells within tumors has been suggested to possess the ability to initiate tumorigenesis and contribute to resistance to cancer therapy. Identification and isolation of this subpopulation in cancer cells can be achieved by detecting specific cell-surface markers. In this study, flow cytometry analysis revealed an abundant CD71+ subpopulation in human papillomavirus (HPV)-positive cervical cancer cells, while limited CD71+ cells were detected in HPV-negative cervical cancer cells. Furthermore, ectopic expression of the HPV-E6 protein in HPV-negative C33A cells enriched the CD71+subpopulation. The CD71+ subpopulation isolated from the C33A cell line and an HPV-E6–overexpressing clone exhibited enhanced transforming ability, proliferation, and resistance to irradiation. In contrast, suppression of CD71 in HPV-positive SiHa cells and the HPV-E6–overexpressing stable clone inhibited spheroid formation and in vitro and in vivo tumorigenicity and sensitized cells to irradiation treatment. CRISPR/Cas9 knockout of CD71 in SiHa cells also produced similar inhibitory effects on tumorigenicity. Double knockout of CD71 and CD55 reversed the oncogenic properties of the HPV-E6–overexpressing clone. These findings suggest that the HPV-E6 protein enriches the subpopulation of CD71+cells in cervical cancer, which exhibit cancer stem–like cell properties and are resistant to irradiation treatment. Targeting the CD71+ subpopulation in cervical cancer cells with siRNAs or CRISPR/Cas9 may provide new insights for the development of novel therapeutic approaches for treating cervical cancer.

Implications:
We describe the enrichment of CD71+ population by HPV-E6 protein in cervical cancer cells that promotes cancer aggressiveness and resistance to irradiation treatment.
Histone Deacetylase Inhibition Sensitizes PD1 Blockade–Resistant B-cell Lymphomas
Authors: Wang Xiaoguang , Waschke Brittany C. , Woolaver Rachel A. , Chen Zhangguo , Zhang Gan , Piscopio Anthony D. , Liu Xuedong , Wang Jing H. 
Published: June 2019

AbstractPD1 blockade is effective in a subset of patients with B-cell lymphoma (e.g., classical-Hodgkin lymphomas); however, most patients do not respond to anti-PD1 therapy. To study PD1 resistance, we used an isoform-selective histone deacetylase inhibitor (HDACi; OKI-179), and a mouse mature B-cell lymphoma, G1XP lymphoma, immunosuppressive features of which resemble those of human B-cell lymphomas, including downregulation of MHC class I and II, exhaustion of CD8+ and CD4+ tumor-infiltrating lymphocytes (TIL), and PD1-blockade resistance. Using two lymphoma models, we show that treatment of B-cell lymphomas refractory to PD1 blockade with both OKI-179 and anti-PD1 inhibited growth; furthermore, sensitivity to single or combined treatment required tumor-derived MHC class I, and positively correlated with MHC class II expression level. We conclude that OKI-179 sensitizes lymphomas to PD1-blockade by enhancing tumor immunogenicity. In addition, we found that different HDACis exhibited distinct effects on tumors and T cells, yet the same HDACi could differentially affect HLA expression on different human B-cell lymphomas. Our study highlights the immunologic effects of HDACis on antitumor responses and suggests that optimal treatment efficacy requires personalized design and rational combination based on prognostic biomarkers (e.g., MHCs) and the individual profiles of HDACi.
Que ninguém entre aqui se não for geômetra
Authors: Moraes Rafael Rodrigues de 
Published: June 2019

Este artigo é reflexo (e reflexão) de uma trajetória de pesquisa intensa sobre o significado verdadeiro de arquitetura entre textos onde seus contextos se inter-relacionam através dos séculos, realizada como produto de pesquisa sobre a essência do projetar em arquitetura, para o projeto de pesquisa Metodologia de Aprendizagem em Arquitetura e Urbanismo (M.A.A.U.). A relação de significado e a perda de, encontra-se em torno do sentido e do discurso de uma origem, ou arché, no que denominados de arquitetura, onde a geometria torna-se palavra fundamentadora; e uma questão de ordem. A denominada geometria sagrada aparenta designar o verdadeiro significado de ser do arquiteto, como discurso intrínseco à busca de sentido na arquitetura.
<p><strong>A new crown wasp in mid-Cretaceous amber from northern Myanmar (Hymenoptera: Stephanidae)</strong></p>
Authors: ENGEL MICHAEL S 
Published: June 2019

The crown wasps, family Stephanidae, are generally believed to occupy a distinguished position as putative relicts of the earliest-diverging lineage of apocritan Hymenoptera (e.g., Sharkey et al., 2012; Mao et al., 2015). More recent analyses have cast some confusion over this hypothesis, with the family instead appearing closer to the Evanioidea or even Trigonalyoidea (Peters et al., 2017; Tang et al., 2019). From most analyses it is clear that the family extends well into the Cretaceous, with crown-group Stephanidae estimated to have appeared by at least the Early Cretaceous and a purported ghost-stem lineage extending into the Early Jurassic or even latest Triassic (Tang et al., 2019). At least parts of such a hypothesis are consistent with the number of mid-Cretaceous fossils representing a variety of crown wasps, including species of both the plesiomorphic subfamily Schlettereriinae as well as putative Stephaninae (Engel & Grimaldi, 2004; Engel et al., 2013; Engel & Huang, 2017; Li et al., 2017). Unfortunately, while such fossil occurrences are of considerable interest, the total available record of fossil crown wasps is poor, with most species documented from the Palaeogene (Engel, 2005; Engel & Ortega-Blanco, 2008), and hitherto only four species from the Late Cretaceous. Given the potentially long gap between the first divergence of the lineage and the appearance of the crown group (Tang et al., 2019), it is precisely for such a group that early diverging stem groups would be of considerable value in resolving relationships and documenting the appearance of apomorphies within the clade. Extensive study of Early Cretaceous and Jurassic deposits for stem-group Stephanidae is necessary in order to provide direct evidence into the early evolution of this critical family of the Euhymenoptera.