bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of 1H NMR Metabolic Profiling of Serum in Canine Multicentric Lymphoma
Authors: Solé Rosina Sánchez , Radcenco Andrés López , Moyna Guillermo , Breijo Martín , Pessina Paula 
Published: December 2024

ABSTRACTCanine lymphoma represents a biologically and metabolically heterogeneous group of neoplasms that arise from malignant transformation of lymphoid cells. An accurate diagnosis is crucial because of its impact on survival. Current diagnostic methods include clinical laboratory tests and imaging, most of which are invasive and lack sensitivity and specificity. Interestingly, recent work in cancer patients focuses on the search for biomarkers for diagnosis, investigation of treatment response mechanisms, treatment efficacy and prognosis and the discovery of tumour metabolic pathways using metabolomic analysis. In this study, we compare the metabolite profiles in serum from 37 dogs with multicentric lymphoma (22 B‐cell lymphomas/LB, 9 CD45+ T‐cell lymphomas/LTCD45+, 6 CD45‐ T‐cell lymphomas/LTCD45‐) and 25 healthy dogs using 1H nuclear magnetic resonance spectroscopy (NMR). 1H NMR‐based metabolite profiling analysis recognised lipids and 22 metabolites, with 16 of them altered, and was shown to be an effective approach for differentiating samples from dogs with lymphoma and healthy controls based on principal component analysis of the NMR data. We also investigated variations in the serum metabolome between immunophenotypes and the control group through pairwise comparisons of the healthy against the LB, LTCD45+ and LTCD45‐ groups, respectively which showed similar metabolomic profiles. In addition, there were significant differences in the levels of five individual metabolites based on the univariate statistical analysis. Our results showed alterations in energy, protein and lipid metabolism, suggesting glucose, lactate, N‐acetyl glycoproteins (NAGs), scyllo‐inositol and choline as possible new candidate biomarkers in canine multicentric lymphoma.
The sparse circular law, revisited
Authors: Sah Ashwin , Sahasrabudhe Julian , Sawhney Mehtaab 
Published: December 2024

AbstractLet be an matrix with iid entries distributed as Bernoulli random variables with parameter . Rudelson and Tikhomirov, in a beautiful and celebrated paper, show that the distribution of eigenvalues of is approximately uniform on the unit disk as as long as , which is the natural necessary condition. In this paper, we give a much simpler proof of this result, in its full generality, using a perspective we developed in our recent proof of the existence of the limiting spectral law when is bounded. One feature of our proof is that it entirely avoids the use of ‐nets and, instead, proceeds by studying the evolution of the singular values of the shifted matrices as we incrementally expose the randomness in the matrix.
On the family of singular Brascamp–Lieb inequalities with dimension datum (1,2,2,1)
Authors: Lin Fred Yu‐Hsiang 
Published: December 2024

AbstractMotivated by the triangular Hilbert transform, we classify a certain family of singular Brascamp–Lieb forms which we associate with the dimension datum (1,2,2,1). We determine the exact range of Lebesgue exponents, for which one has singular Brascamp–Lieb inequalities within this family. The remaining observations concern counter examples to boundedness. We compare with a counter‐example showing that the triangular Hilbert form does not satisfy singular Brascamp–Lieb bounds in the endpoints.
Using environmental and exercise physiology to address gender inequalities in climate change and occupational health research
Authors: Lucas Rebekah A. I. 
Published: December 2024

AbstractClimate change is a health‐risk and health‐inequity multiplier with excessive heat exposure a direct climate change impact already affecting the health and livelihood of billions globally. Women face greater risks and burdens from climate change impacts. Biological sex may or may not influence an individual's thermoregulatory capacity, heat tolerance or heat susceptibility. However at a population level, sex differences in physiological characteristics (anthropometrics, aerobic capacity, etc.) likely affect thermoregulatory capacity. Still, gender appears to play the most significant role in heat exposure and resulting health impacts. For climate change resilience and adaptation strategies to be effective, public health and occupational guidance/governance must be based on comprehensive and representative evidence. The current dearth of empirical evidence on how excessive heat exposure affects women prohibits this. Environmental and exercise physiology can help address this lack of empirical evidence by adhering to inclusive research guidelines. This paper is based on a symposium presentation given at Physiology 2023 in Harrogate, UK. Using a multi‐year cohort study on industrial agricultural workers (the Adelante Initiative) as a case study, this review discusses the role of environmental and exercise physiology in generating inclusive research and evidence to inform occupational and public health guidance/governance for climate change resilience and adaptation, specifically heat exposure.
Surviving the storm: exploring the role of natural transformation in nutrition and DNA repair of stressed
Deinococcus radiodurans
Authors: Sharma Dhirendra Kumar , Soni Ishu , Rajpurohit Yogendra Singh 
Published: December 2024

ABSTRACT

Deinococcus radiodurans
, a natural transformation (NT)-enabled bacterium renowned for its exceptional radiation resistance, employs unique DNA repair and oxidative stress mitigation mechanisms as a strategic response to DNA damage. This study excavates into the intricate roles of NT machinery in the stressed
D. radiodurans
, focusing on the genes
comEA
,
comEC
,
endA
,
pilT
, and
dprA
, which are instrumental in the uptake and processing of extracellular DNA (eDNA). Our data reveal that NT not only supports the nutritional needs of
D. radiodurans
under stress but also has roles in DNA repair. The study findings establish that NT-specific proteins (ComEA, ComEC, and endonuclease A [EndA]) may contribute to support the nutritional requirements in unstressed and heavily DNA-damaged cells, while DprA contributes differently and in a context-dependent manner to navigating through the DNA damage storm. Thus, this dual functionality of NT-specific genes is proposed to be a contributing factor in the remarkable ability of
D. radiodurans
to survive and thrive in environments characterized by high levels of DNA-damaging agents.

IMPORTANCE

Deinococcus radiodurans
is a bacterium known for its extraordinary radiation resistance. This study explores the roles of NT machinery in the radiation-resistant bacterium
Deinococcus radiodurans
, focusing on the genes
comEA
,
comEC
,
endA
,
pilT
, and
dprA
. These genes are crucial for the uptake and processing of eDNA and contribute to the bacterium nutritional needs and DNA repair under stress. The findings suggest that the NT-specific proteins ComEA, ComEC, and EndA may help meet the nutritional needs of unstressed and heavily DNA-damaged cells, whereas DprA plays a distinct role that varies, depending on the context in aiding cells to cope with DNA damage. The functionality of NT genes is proposed to enhance
D. radiodurans
survival in environments with high levels of DNA-damaging agents.
Nutrient amendments enrich microbial hydrocarbon degradation metagenomic potential in freshwater coastal wetland microcosm experiments
Authors: Howland Katie E. , Mouradian Jack J. , Uzarski Donald R. , Henson Michael W. , Uzarski Donald G. , Learman Deric R. 
Published: December 2024

ABSTRACT

Biostimulating native microbes with fertilizers has proven to be a highly effective strategy to speed up biodegradation rates in microbial communities. This study investigates the genetic potential of microbes to degrade light synthetic crude oil in a freshwater coastal wetland. Experimental sediment microcosms were exposed to a variety of conditions (biological control, a light synthetic crude oil amendment, and light synthetic crude oil with nutrient amendment) and incubated for 30 days before volatile organic compounds (BTEX) were quantified and DNA was sequenced for metagenomic analysis. The resulting DNA sequences were binned into metagenome-assembled genomes (MAGs). Analyses of MAGs uncovered a 13-fold significant increase in the abundance of rate-limiting hydrocarbon degrading monooxygenases and dioxygenases, identified only in MAGs from the light synthetic crude oil with nutrient amendments. Further, complete degradation pathways for BTEX compounds were found only in MAGs resulting from the light synthetic crude with nutrient amendment. Moreover, volatile organic compounds (BTEX, cyclohexane, and naphthalene) analyses of microcosm sediments in the presence of nutrients documented that benzene was degraded below detection limits, toluene (98%) and ethylbenzene (67%) were predominantly reduced within 30 days. Results indicate that the genetic potential to degrade BTEX compounds in this freshwater wetland can be linked to the functional potential for bioremediation. BTEX compounds are typically more recalcitrant and tougher to degrade than alkanes. This study demonstrated that stimulating a microbial community with nutrients to enhance its ability to biodegrade hydrocarbons, even in a relatively nutrient-rich habitat like a freshwater wetland, is an effective remediation tactic.

IMPORTANCE
The impact of oil spills in a freshwater aquatic environment can pose dire social, economic, and ecological effects on the region. An oil spill in the Laurentian Great Lakes region has the potential to affect the drinking water of more than 30 million people. The light synthetic crude oil used in this experimental microcosm study is transported through an underground pipeline crossing the waterway between two Laurentian Great Lakes. This study collected metagenomic data (experiments in triplicate) and assessed the quantity of BTEX compounds, which connected microbial degradation function to gene potential. The resulting data documented the bioremediation capabilities of native microbes in a freshwater coastal wetland. This study also provided evidence for this region that bioremediation can be a viable remediation strategy instead of invasive physical methods.
Two rice cultivars recruit different rhizospheric bacteria to promote aboveground regrowth after mechanical defoliation
Authors: Jiang Changjin , Wang Fei , Tian Jinling , Zhang Wanyuan , Xie Kabin 
Published: December 2024

ABSTRACT

Plants have evolved the ability to regrow after mechanical defoliation and environmental stresses. However, it is unclear whether and how defoliated plants exploit beneficial microbiota from the soil to promote aboveground regrowth. Here, we compared the defoliation-triggered changes in the root exudation and bacterial microbiome of two rice cultivars (
Oryza sativa
L
ssp
.),
indica/xian
cultivar Minghui63 and
japonica/geng
cultivar Nipponbare. The results show that reciprocal growth promotion existed between defoliated Minghui63 seedlings and soil bacteria. After the leaves were removed, the Minghui63 seedlings displayed approximately 1.5- and 2.1-fold higher root exudation and leaf regrowth rates, respectively, than did the Nipponbare seedlings. In field trials, Minghui63 and Nipponbare enriched taxonomically and functionally distinct bacteria in the rhizosphere and root. In particular, Minghui63 rhizosphere and root communities depleted bacteria whose functions are related to xenobiotics biodegradation and metabolism. The microbiome data implied that the bacterial family
Rhodocyclaceae
was specifically enriched during the regrowth of defoliated Minghui63 rice. We further isolated a
Rhodocyclaceae
strain,
Uliginosibacterium gangwonense
MDD1, from rice root. Compared with germ-free conditions, MDD1 inoculation promoted the aboveground regrowth of defoliated Minghui63 by 61% but had a weaker effect on Nipponbare plants, suggesting cultivar-specific associations between regrowth-promoting bacteria and rice. This study provides novel insight into microbiota‒root‒shoot communication, which is implicated in the belowground microbiome and aboveground regrowth in defoliated rice. These data will be helpful for microbiome engineering to increase rice resilience to defoliation and environmental stresses.

IMPORTANCE

As sessile organisms, plants face a multitude of abiotic and biotic stresses which often result in defoliation. To survive, plants have evolved the ability to regrow leaves after stresses and wounding. Previous studies revealed that the rhizosphere microbiome affected plant growth and stress resilience; however, how belowground microbiota modulates the aboveground shoot regrowth is unclear. To address this question, we used rice, an important crop worldwide, to analyze the role of rhizosphere microbiota in leaf regrowth after defoliation. Our data indicate mutual growth promotion between defoliated rice and rhizosphere bacteria and such beneficial effect is cultivar specific. The microbiome analysis also led us to find a
Uliginosibacterium gangwonense
strain that promoted rice cv. MH63 leaf regrowth. Our findings therefore present a novel insight into plant-microbiome function and provide beneficial strains that potentially enhance rice stress resilience.
Health policy to address disease-related malnutrition: a scoping review
Authors: Ford Katherine L , Basualdo-Hammond Carlota , Nasser Roseann , Avdagovska Melita , Keller Heather , Malone Ainsley , Bauer Judy D , Correia M Isabel T D , Cardenas Diana , Gramlich Leah 
Published: December 2024

BackgroundHealth policies promote optimal care, yet policies that address disease-related malnutrition (DRM) are lacking. The purpose of this study was to conduct a scoping review to identify literature on existing and planned policy to address DRM in children or adults and explore the settings, contexts and actors of DRM policy.MethodsA search strategy comprising DRM and policy keywords was applied to eight databases on 24 February 2023. Articles that addressed DRM and policy were selected for inclusion after two independent reviews. The health policy triangle (HPT) framework (ie, actors, content, contexts and processes considerations for policy) guided data extraction and thematic analysis.ResultsA total of 67 articles were included out of the 37 196 identified. Some articles (n=14) explored established policies at the local level related to food and mealtime, nutrition care practices, oral nutritional supplement prescribing or reimbursement. Other articles gave direction or rationale for DRM policy. As part of the HPT, actors included researchers, advocacy groups and DRM champions while content pertained to standard processes for nutrition care such as screening, assessment, intervention and monitoring. Contexts included acute care and care home settings with a focus on paediatrics, adults, older adults. Processes identified were varied and influenced by the type of policy (eg, local, national, international) and its goal (eg, advocating, developing, implementing).DiscussionThere is a paucity of global DRM policy. Nutrition screening, assessment, intervention and monitoring are consistently identified as important to DRM policy. Decision makers are important actors and should consider context, content and processes to develop and mobilise DRM policy to improve nutrition care. Future efforts need to prioritise the development and implementation of policies addressing DRM.
Lymphoid enhancer-binding factor 1 (LEF1) immunostaining as a surrogate for β-catenin (CTNNB1) mutations
Authors: Hewer Ekkehard , Fischer Pascal David , Vassella Erik , Knabben Laura , Imboden Sara , Mueller Michael D , Rau Tilman T , Dettmer Matthias S 
Published: December 2024

AimsMutations affecting exon 3 of the β-catenin (CTNNB1) gene result in constitutive activation of WNT signalling and are a diagnostic hallmark of several tumour entities including desmoid-type fibromatosis. They also define clinically relevant tumour subtypes within certain entities, such as endometrioid carcinoma. In diagnostics, β-catenin immunohistochemistry is widely used as a surrogate forCTNNB1mutations. Yet, it is often difficult to assess in practice, given that the characteristic nuclear translocation may be focal or hard to distinguish from the spillover of the normal membranous staining.MethodsWe therefore examined lymphoid enhancer-binding factor 1 (LEF1) immunostaining, a nuclear marker of WNT activation that serves as a potential surrogate forCTNNB1mutations.ResultsIn a cohort of endometrial carcinomas with known mutation status (n=130) LEF1 was 85% accurate in predictingCTNNB1mutation status (64% sensitivity, 90% specificity) while β-catenin was 76% accurate (72% sensitivity; 77% specificity). Across a variety of entities characterised byCTNNB1mutations as putative drivers, we found diffuse and strong expression of LEF1 in 77% of cases. LEF1 immunostaining proved easier to interpret than β-catenin immunostaining in 54% of cases, more difficult in 1% of cases and comparable in the remaining cases.ConclusionWe conclude that LEF1 immunostaining is a useful surrogate marker forCTNNB1mutations. It favourably complements β-catenin immunohistochemistry and outperforms the latter as a single marker.
Aortic and arterial manifestations and clinical features inTGFB3-related heritable thoracic aortic disease: results from the Montalcino Aortic Consortium
Authors: Lim Michelle Su-Anne , Guo Dong-Chuan , Velasco Torrez Walter , Lai Andrew , Schweber Jonathan , Garg Nikita , Fleischer Julie , Boileau Catherine , De Backer Julie , Evangelista Artur , Jondeau Guillaume , Le Goff Carine , Milleron Olivier , Muiño-Mosquera Laura , Morris Shaine , Ouzounian Maral , Cervi Elena , Marcadier Julien , Caffarelli Anthony , Shalhub Sherene , Pyeritz Reed , Yetman Angela , Milewicz Dianna , Braverman Alan C 
Published: December 2024

BackgroundPathogenic variants inTGFB3may lead to a syndromic genetic aortopathy. Heritable thoracic aortic disease (HTAD) and arterial events may occur inTGFB3-related disease but there are limited outcomes data on vascular events in this condition.MethodsClinical data, phenotypical features and aortic outcomes in individuals with pathogenic/likely pathogenic (P/LP)TGFB3variants enrolled in the Montalcino Aortic Consortium registry were reviewed.Results34 individuals (56% male, median age 42 years, IQR 17–49, range 3–74 years) with P/LPTGFB3variants were studied. Craniofacial, cutaneous and musculoskeletal features seen in Loeys-Dietz syndrome were variably present. Extra-aortic cardiovascular features included arterial tortuosity (25%), extra-aortic arterial aneurysms (6%) and mitral valve prolapse (21%).Aortic dilation (Z-Score>2) was present in 10 individuals (29%) and aortic dissection occurred in 2 (6%). Type A aortic dissection occurred in two patients (aged between 55 years and 60 years), and one of these patients experienced a type B aortic dissection 6 years later. Seven adults (median age 62 years, range 32–69 years) with aortic root dilation (41–49 mm) are being followed. No patients have undergone prophylactic aortic surgery. Twenty-five per cent of children have aortic dilation. Sixty-eight per cent of the entire cohort remains free of aortic disease. No deaths have occurred.ConclusionsTGFB3-related HTAD is characterised by late-onset and less penetrant thoracic aortic and arterial disease compared with other transforming growth factor β HTAD. Based on our data, a larger aortic size threshold for prophylactic aortic surgery is appropriate in patients withTGFB3-related HTAD compared with HTAD due toTGFBR1orTGFBR2variants.
Exploring SMEFT couplings using the forward–backward asymmetry in neutral current Drell–Yan production at the LHC
Authors:   the xFitter Developers’ team, Abdolmaleki Hamed , Amoroso Simone , Britzger Daniel , Dattola Filippo , Fiaschi Juri , Giuli Francesco , Glazov Alexander , Hautmann Francesco , Luszczak Agnieszka , Monfared Sara Taheri , Olness Fred , Vazzoler Federico , Zenaiev Oleksandr , Anataichuk Andrii , Moch Sven-Olaf 
Published: December 2024

Abstract
Neutral current Drell–Yan (DY) lepton-pair production is considered to study Z-boson quark couplings. Using the open-source fit platform , we investigate the impact of high-statistics measurements of the neutral current DY (NCDY) forward–backward asymmetry

$$A_{\textrm{FB}}$$

A
FB

near the weak boson mass scale in the present and forthcoming stages of the Large Hadron Collider (LHC). Besides recovering earlier results on the

$$A_{\textrm{FB}}$$

A
FB

sensitivity to parton distribution functions, we analyze the precision determination of Z-boson couplings to left-handed and right-handed u-quarks and d-quarks, and explore Beyond-Standard-Model contributions using the Standard Model Effective Field Theory (SMEFT) framework. We perform a sensitivity study and comment on the role of the

$$A_{\textrm{FB}}$$

A
FB

asymmetry for the electroweak SMEFT fit and precision Z-boson physics at the LHC and high-luminosity HL-LHC.
Stationary BTZ space-time in Ricci-inverse and $$f({\mathcal {R}})$$ gravity theories
Authors: Ahmed Faizuddin , Bouzenada Abdelmalek 
Published: December 2024

Abstract
In this paper, we explore a stationary BTZ space-time within the framework of modified gravity theory, specifically focusing on Ricci-inverse gravity. It is important to clarify that “Ricci-inverse” refers to the inverse of the Ricci tensor, not the Ricci scalar. We consider a general class of this gravity theory, where the function f is defined by

$$f({\mathcal {R}}, {\mathcal {A}}, A^{\mu \nu }\,A_{\mu \nu })$$

f
(
R
,
A
,

A

μ
ν

A

μ
ν

)

, with

$${\mathcal {R}}$$

R

and

$${\mathcal {A}}$$

A

representing the Ricci and anti-curvature scalars, respectively and

$$A^{\mu \nu }$$

A

μ
ν

is the anti-curvature tensor. We demonstrate that stationary BTZ space-time is a valid solution in this gravity theory, wherein the cosmological constant undergoes modifications due to the coupling constants. Moreover, we study another modified gravity theory known as

$$f({\mathcal {R}})$$

f
(
R
)

-gravity and analyze the stationary BTZ space-time. Subsequently, we fully integrate the geodesic equations for BTZ space-time constructed within the Ricci-Inverse gravity, expressing the solutions in terms of elementary functions and compared with the GR result. We classify different types of geodesics, including null and time-like geodesics, under three conditions: (i) nonzero mass and angular momentum,

$$M \ne 0, J\ne 0$$

M
≠
0
,
J
≠
0

, (ii) massless BTZ space-time,

$$M=0$$

M
=
0

and

$$J=0$$

J
=
0

, and (iii)

$$M=-1, J=0$$

M
=
-
1
,
J
=
0

, that is

$$AdS_3$$

A
d

S
3

-type, and analyze the results in modified gravity theories and compare with the general relativity case.
Fermion dark matter in the vector scotogenic model: a survey of signatures
Authors: Areyuna C Paulo , Zamora-Saa Jilberto , Zerwekh Alfonso R. 
Published: December 2024

Abstract
In this work, we have studied the vector scotogenic model in the context of the dark matter problem. Due to unitarity considerations, we have focused on the scenario with fermion dark matter, finding out that co-annihilations play a fundamental role in achieving dark matter relic abundance. Moreover, the coannihilation effects allow to separate the parameter space into two regions with different phenomenology. In addition, we have studied the detection prospects of these regions separately, focusing on signatures that can appear in lepton flavor violating decays, indirect and direct searches, and the production of these new particles at collider facilities.