bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tailoring a training based on the Mental Health Gap Action Programme (mhGAP) Intervention Guide (IG) to Tunisia: process and relevant adaptations
Authors: Spagnolo Jessica , Champagne François , Leduc Nicole , Melki Wahid , Guesmi Imen , Bram Nesrine , Guisset Ann-Lise , Piat Myra , Laporta Marc , Charfi Fatma 
Published: May 2018

BackgroundIn order to make mental health services more accessible, the Tunisian Ministry of Health, in collaboration with the School of Public Health at the University of Montreal, the World Health Organization office in Tunisia and the Montreal World Health Organization-Pan American Health Organization Collaborating Center for Research and Training in Mental Health, implemented a training programme based on the Mental Health Gap Action Programme (mhGAP) Intervention Guide (IG) (version 1.0), developed by the World Health Organization. This article describes the phase prior to the implementation of the training, which was offered to general practitioners working in primary care settings in the Greater Tunis area of Tunisia.MethodsThe phase prior to implementation consisted of adapting the standard mhGAP-IG (version 1.0) to the local primary healthcare context. This adaptation process, an essential step before piloting the training, involved discussions with stakeholder groups, as well as field observations.ResultsThrough the adaptation process, we were able to make changes to the standard training format and material. In addition, the process helped uncover systemic barriers to effective mental health care.ConclusionsTargeting these barriers in addition to implementing a training programme may help reduce the mental health treatment gap, and promote implementation that is successful and sustainable.
Simple Trinitarianism and empty names
Authors: KLEINSCHMIDT SHIEVA 
Published: May 2018

AbstractAccording to Simple Trinitarianism, God is mereologically simple, and the Father, Son, and Holy Spirit are not identified with any entities in our ontology. Thus the Simple Trinitarian is able to avoid conflating Persons or multiplying Gods, and does not have to identify the Persons with minor entities or entities partly disjoint from God. However, to maintain that Trinitarian sentences are nonetheless true, the Simple Trinitarian will need a non-standard semantics. I explore one option for this, involving taking ‘the Father’, ‘the Son’, and ‘the Holy Spirit’ to be empty names. By adopting a positive, Free Logic, we can take these names to make semantic contributions and play roles in true sentences, while blocking problematic inferences.
Blind to Chains? The Potential of Bioarchaeology for Identifying the Enslaved of Roman Britain
Authors: Redfern Rebecca C. 
Published: May 2018

AbstractThis research explores the contribution bioarchaeology can make to the study of slavery in Roman Britain, responding to the calls by Webster and colleagues for the greater use of osteological and scientific techniques in this endeavour. It reviews the evidence for the bodies of the enslaved in the primary sources and bioarchaeological evidence from the New World and the Roman Empire. The paper aims to establish patterns of physiological stress and disease, which could be used to reconstruct osteobiographies of these individuals, and applies these findings to bioarchaeological evidence from Britain. It concludes that at the present time, it may not be possible for us to successfully separate out the enslaved from the poor or bonded labourers, because their life experiences were very similar. Nevertheless, these people are overlooked in the archaeological record, so unless we attempt to search for them in the extant evidence, the life experiences of the majority of the Romano-British population who were vital to its economy will remain lost to us.
A 3D, performance-driven generative design framework: automating the link from a 3D spatial grammar interpreter to structural finite element analysis and stochastic optimization
Authors: Zimmermann Luca , Chen Tian , Shea Kristina 
Published: May 2018

AbstractSince the introduction of spatial grammars 45 years ago, numerous grammars have been developed in a variety of fields from architecture to engineering design. Their benefits for solution space exploration when computationally implemented and combined with optimization have been demonstrated. However, there has been limited adoption of spatial grammars in engineering applications for various reasons. One main reason is the missing, automated, generalized link between the designs generated by the spatial grammar and their evaluation through finite-element analysis (FEA). However, the combination of spatial grammars with optimization and simulation has the advantage over continuous structural topology optimization in that explicit constraints, for example, modeling style and fabrication processes, can be included in the spatial grammar. This paper discusses the challenges in providing a generalized approach by demonstrating the implementation of a framework that combines a three-dimensional spatial grammar interpreter with automated FEA and stochastic optimization using simulated annealing (SA). Guidelines are provided for users to design spatial grammars in conjunction with FEA and integrate automatic application of boundary conditions. A simulated annealing method for use with spatial grammars is also presented including a new method to select rules through a neighborhood definition. To demonstrate the benefits of the framework, it is applied to the automated design and optimization of spokes for inline skate wheels. This example highlights the advantage of spatial grammars for modeling style and additive manufacturing (AM) constraints within the generative system combined with FEA and optimization to carry out topology and shape optimization. The results verify that the framework can generate structurally optimized designs within the style and AM constraints defined in the spatial grammar, and produce a set of topologically diverse, yet valid design solutions.
Algorithmic complexity of shape grammar implementation
Authors: Wortmann Thomas , Stouffs Rudi 
Published: May 2018

AbstractComputer-based shape grammar implementations aim to support creative design exploration by automating rule-application. This paper reviews existing shape grammar implementations in terms of their algorithmic complexity, extends the definition of shape grammars with sets of transformations for rule application, categorizes (parametric and non-parametric) sets of transformations, and analyses these categories in terms of the resulting algorithmic complexity. Specifically, it describes how different sets of transformations admit different numbers of targets (i.e., potential inputs) for rule application. In the non-parametric case, this number is quadratic or cubic, while in the parametric case, it can be non-polynomial, depending on the size of the target shape. The analysis thus yields lower bounds for the algorithmic complexity of shape grammar implementations that hold independently of the employed algorithm or data structure. Based on these bounds, we propose novel matching algorithms for non-parametric and parametric shape grammar implementation and analyze their complexity. The results provide guidance for future, general-purpose shape grammar implementations for design exploration.
Generic grammars for design domains
Authors: Beirão José , Duarte José P. 
Published: May 2018

AbstractShape grammars have been developed to codify a specific type of artifact – Queen Anne houses, Buffalo bungalows – or the style of a particular designer – Andrea Palladio, Frank Lloyd Wright, or Álvaro Siza Vieira. However, these specific grammars fail to encode recurrent design moves or features that are above the particularities of a specific design style or the idiosyncrasies of a specific designer and, therefore, are common to a larger category of designs and maybe reutilized and incorporated in the definition of new, specific design languages. To overcome these limitations, the notion of generic grammars for defining design domains is introduced. Its application to the urban design domain is illustrated by showing a generic grammar implementation resulting in a City Information Modeling platform composed of a parametric design interface connected to a geographic database.
Interannual Variability of the Daytime Equatorial Ionospheric Electric Field
Authors: Yamazaki Yosuke , Stolle Claudia , Matzka Jürgen , Liu Huixin , Tao Chihiro 
Published: May 2018

AbstractUnderstanding the variability of the ionosphere is important for the prediction of space weather and climate. Recent studies have shown that forcing from the lower atmosphere plays a significant role for the short‐term (day‐to‐day) variability of the low‐latitude ionosphere. The present study aims to assess the importance of atmospheric forcing for the variability of the daytime equatorial ionospheric electric field on the interannual (year‐to‐year) time scale. Magnetic field measurements from Huancayo (12.05°S, 75.33°W) are used to augment the equatorial vertical plasma drift velocity (VZ) measurements from the Jicamarca Unattended Long‐term Investigations of the Ionosphere and Atmosphere radar during 2001–2016. VZ can be regarded as a measure of the zonal electric field. After removing the seasonal variation of ∼10 m/s, midday values of VZ show an interannual variation of ∼2 m/s with an oscillation period of 2–3 years. No evidence of solar cycle influence is found. The Ground‐to‐topside Atmosphere‐Ionosphere model for Aeronomy, which takes into account realistic atmospheric variability below 30 km, reproduces the pattern of the observed interannual variation without having to include variable forcing from the magnetosphere. The results indicate that lower atmospheric forcing plays a dominant role for the observed interannual variability of VZ at 1200 local time.
Atmospheric Mechanisms for MJO Decay Over the Maritime Continent
Authors: DeMott Charlotte A. , Wolding Brandon O. , Maloney Eric D. , Randall David A. 
Published: May 2018

AbstractEastward propagating Madden‐Julian oscillation (MJO) events that develop in the Indian Ocean from November to April are separated into events whose convective anomalies do and do not propagate across the Maritime Continent (MC). Propagating (P) events are divided into strong (sP) and weak (wP) subsets based on the initial amplitudes of their convective anomalies. Eastward decaying (ED) MJO events have initial amplitudes similar to those of wP events. Roughly half of all MJO events encounter westward propagating transient dry precursor (TDP) signals over the MC. These TDPs, which are external to the MJO circulation system, overwhelm the weak, eastward propagating moist anomaly in ED events, leading to MJO termination. In wP events, the MJO moist anomaly is stronger than the TDP dry anomaly, and the MJO propagates beyond the MC. ED MJO events that do not encounter TDPs decay because of insufficient moistening in the southern MC region. The background states of TDP‐ and non‐TDP‐affected MJO events resemble La Niña and El Niño conditions, respectively. The regional regulation of TDP activity and background moisture gradients by El Niño–Southern Oscillation can both be understood in terms of the zonal shift and the meridional expansion or contraction of Warm Pool moisture in response to El Niño–Southern Oscillation sea surface temperature anomalies. Our results demonstrate that modulation of TDPs by the background state moisture can affect the MJO in a manner that reinforces its propagation or decay via the interaction of MJO circulation anomalies and background moisture gradients.
Inversion of Multifrequency Data With the Cross‐Correlated Contrast Source Inversion Method
Authors: Sun Shilong , Kooij Bert‐Jan , Yarovoy Alexander G. 
Published: May 2018

AbstractCross‐correlated contrast source inversion (CC‐CSI) is a nonlinear iterative inversion method that is proposed recently for solving the inverse scattering problems. In CC‐CSI, a cross‐correlated error is constructed and introduced to the cost functional, which improves the inversion ability when compared to the classical design of the cost functional by exploiting the mismatch between the data error and state error. In this paper, the multifrequency inversion for electromagnetic waves is considered and a multifrequency version of CC‐CSI is proposed. Numerical and experimental inversion results of both transverse magnetic and transverse electric polarization demonstrate that when multifrequency data are available, CC‐CSI still outperforms the multiplicative‐regularized CSI method in the inversion of more complicated scatterers.
The Intensity, Directionality, and Statistics of Underwater Noise From Melting Icebergs
Authors: Glowacki Oskar , Deane Grant B. , Moskalik Mateusz 
Published: May 2018

AbstractFreshwater fluxes from melting icebergs and glaciers are important contributors to both sea level rise and anomalies of seawater salinity in polar regions. However, the hazards encountered close to icebergs and glaciers make it difficult to quantify their melt rates directly, motivating the development of cryoacoustics as a remote sensing technique. Recent studies have shown a qualitative link between ice melting and the accompanying underwater noise, but the properties of this signal remain poorly understood. Here we examine the intensity, directionality, and temporal statistics of the underwater noise radiated by melting icebergs in Hornsund Fjord, Svalbard, using a three‐element acoustic array. We present the first estimate of noise energy per unit area associated with iceberg melt and demonstrate its qualitative dependence on exposure to surface current. Finally, we show that the analysis of noise directionality and statistics makes it possible to distinguish iceberg melt from the glacier terminus melt.
Observations of Mud‐Induced Periodic Stratification in a Hyperturbid Estuary
Authors: Becker Marius , Maushake Christian , Winter Christian 
Published: May 2018

AbstractThis study presents new observations of fluid mud transport and of the interaction between mud‐induced stratification and the flow. Data collected in a hyperturbid estuarine tidal channel reveal details of the intratidal entrainment asymmetry, characterized by quasi‐instantaneous entrainment and upstream pumping of mud during flood, and a gradual reduction of layer thickness by shear dispersion during ebb. Rapid restratification early during the flood phase restores the predominant two‐layer structure and delimits the transport period, which is then significantly shorter than the overall flood duration. The hydraulic cross section is reduced, causing an increase of the salinity intrusion into the estuary at the end of the flood. The fluid mud layer occupies on average 40% of the water depth, and stratification exceeds that of highly stratified salt wedge estuaries. These data show how mud‐induced periodic stratification influences flow structure and sediment transport and thereby contribute to the understanding of the dynamics of hyperturbid estuaries.
Interchange Injections at Saturn: Statistical Survey of Energetic H+ Sudden Flux Intensifications
Authors: Azari Abigail R. , Liemohn Michael W. , Jia Xianzhe , Thomsen Michelle F. , Mitchell Donald G. , Sergis Nick , Rymer Abigail M. , Hospodarsky George B. , Paranicas Christopher , Vandegriff Jon 
Published: May 2018

AbstractWe present a statistical study of interchange injections in Saturn's inner and middle magnetosphere focusing on the dependence of occurrence rate and properties on radial distance, partial pressure, and local time distribution. Events are evaluated from over the entirety of the Cassini mission's equatorial orbits between 2005 and 2016. We identified interchange events from CHarge Energy Mass Spectrometer (CHEMS) H+ data using a trained and tested automated algorithm, which has been compared with manual event identification for optimization. We provide estimates of interchange based on intensity, which we use to investigate current inconsistencies in local time occurrence rates. This represents the first automated detection method of interchange, estimation of injection event intensity, and comparison between interchange injection survey results. We find that the peak rates of interchange occur between 7 and 9 Saturn radii and that this range coincides with the most intense events as defined by H+ partial particle pressure. We determine that nightside occurrence dominates as compared to the dayside injection rate, supporting the hypothesis of an inversely dependent instability growth rate on local Pedersen ionospheric conductivity. Additionally, we observe a slight preference for intense events on the dawnside, supporting a triggering mechanism related to large‐scale injections from downtail reconnection. Our observed local time dependence paints a dynamic picture of interchange triggering due to both the large‐scale injection‐driven process and ionospheric conductivity.
Stratospheric Response in the First Geoengineering Simulation Meeting Multiple Surface Climate Objectives
Authors: Richter Jadwiga, H. , Tilmes Simone , Glanville Anne , Kravitz Ben , MacMartin Douglas G. , Mills Michael J. , Simpson Isla R. , Vitt Francis , Tribbia Joseph J. , Lamarque Jean‐Francois 
Published: May 2018

AbstractWe describe here changes in stratospheric dynamics and chemistry in a first century‐long sulfate aerosol geoengineering simulation in which the mean surface temperature and the interhemispheric and equator‐to‐pole surface temperature gradients were kept near their 2020 levels despite the RCP8.5 emission scenario. Simulations were carried out with the Community Earth System Model, version 1 with the Whole Atmosphere Community Climate Model as its atmospheric component [CESM1(WACCM)] coupled to a feedback algorithm controlling the magnitude of sulfur dioxide (SO2) injections at four injection latitudes. We find that, throughout the entire geoengineering simulation, the lower stratospheric temperatures increase by ∼0.19 K per Tg SO2 injection per year or ∼10 K with ∼40 Tg SO2/year total SO2 injection. These temperature changes are associated with a strengthening of the polar jets in the stratosphere and weakening of the mean zonal wind in the lower stratosphere subtropics and throughout the troposphere, associated with weaker storm track activity. In the geoengineering simulation the quasi‐biennial oscillation of the tropical lower stratospheric winds remains close to the presently observed quasi‐biennial oscillation, even for large amounts of SO2 injection. Water vapor in the stratosphere increases substantially: by 25% with ∼20 Tg SO2/year annual injection and by up to 90% with a ∼40 Tg SO2/year injection. Stratospheric column ozone in the geoengineering simulation is predicted to recover to or supersede preozone hole conditions by the end of the century.
miR-338-3p functions as a tumor suppressor in gastric cancer by targeting PTP1B
Authors: Sun Feng , Yu Mengchao , Yu Jing , Liu Zhijian , Zhou Xinyan , Liu Yanqing , Ge Xiaolong , Gao Haidong , Li Mei , Jiang Xiaohong , Liu Song , Chen Xi , Guan Wenxian 
Published: May 2018

AbstractGastric cancer (GC) is one of the most common malignant tumors and peritoneal metastasis is the primary cause for advanced GC’s mortality. Protein-tyrosine phosphatase 1B (PTP1B) functions as an oncogene and involves in carcinogenesis and cancer dissemination. However, the function and regulation of PTP1B in GC remain poorly understood. In this study, we found that PTP1B was upregulated in GC tissues and overexpression of PTP1B in vitro promoted cell migration and prevented apoptosis. Then, we predicted that PTP1B was a target of miR-338-3p and we revealed an inverse correlation between miR-338-3p levels and PTP1B protein levels in GC tissues. Next, we verified that PTP1B was inhibited by miR-338-3p via direct targeting to its 3′-untranslated regions. Moreover, overexpression of miR-338-3p in vitro attenuated GC cell migration and promoted apoptosis, and these effects could be partially reversed by reintroduction of PTP1B. Finally, we established an orthotopic xenograft model and a peritoneal dissemination model of GC to demonstrate that miR-338-3p restrained tumor growth and dissemination in vivo by targeting PTP1B. Taken together, our results highlight that PTP1B is an oncogene and is negatively regulated by miR-338-3p in GC, which may provide new insights into novel molecular therapeutic targets for GC.
Ambipolar ferromagnetism by electrostatic doping of a manganite
Authors: Zheng L. M. , Wang X. Renshaw , Lü W. M. , Li C. J. , Paudel T. R. , Liu Z. Q. , Huang Z. , Zeng S. W. , Han Kun , Chen Z. H. , Qiu X. P. , Li M. S. , Yang Shize , Yang B. , Chisholm Matthew F. , Martin L. W. , Pennycook S. J. , Tsymbal E. Y. , Coey J. M. D. , Cao W. W. 
Published: May 2018

AbstractComplex-oxide materials exhibit physical properties that involve the interplay of charge and spin degrees of freedom. However, an ambipolar oxide that is able to exhibit both electron-doped and hole-doped ferromagnetism in the same material has proved elusive. Here we report ambipolar ferromagnetism in LaMnO3, with electron–hole asymmetry of the ferromagnetic order. Starting from an undoped atomically thin LaMnO3 film, we electrostatically dope the material with electrons or holes according to the polarity of a voltage applied across an ionic liquid gate. Magnetotransport characterization reveals that an increase of either electron-doping or hole-doping induced ferromagnetic order in this antiferromagnetic compound, and leads to an insulator-to-metal transition with colossal magnetoresistance showing electron–hole asymmetry. These findings are supported by density functional theory calculations, showing that strengthening of the inter-plane ferromagnetic exchange interaction is the origin of the ambipolar ferromagnetism. The result raises the prospect of exploiting ambipolar magnetic functionality in strongly correlated electron systems.
Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
Authors: Ai Rizi , Laragione Teresina , Hammaker Deepa , Boyle David L. , Wildberg Andre , Maeshima Keisuke , Palescandolo Emanuele , Krishna Vinod , Pocalyko David , Whitaker John W. , Bai Yuchen , Nagpal Sunil , Bachman Kurtis E. , Ainsworth Richard I. , Wang Mengchi , Ding Bo , Gulko Percio S. , Wang Wei , Firestein Gary S. 
Published: May 2018

AbstractEpigenetics contributes to the pathogenesis of immune-mediated diseases like rheumatoid arthritis (RA). Here we show the first comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS), including histone modifications (H3K27ac, H3K4me1, H3K4me3, H3K36me3, H3K27me3, and H3K9me3), open chromatin, RNA expression and whole-genome DNA methylation. To address complex multidimensional relationship and reveal epigenetic regulation of RA, we perform integrative analyses using a novel unbiased method to identify genomic regions with similar profiles. Epigenomically similar regions exist in RA cells and are associated with active enhancers and promoters and specific transcription factor binding motifs. Differentially marked genes are enriched for immunological and unexpected pathways, with “Huntington’s Disease Signaling” identified as particularly prominent. We validate the relevance of this pathway to RA by showing that Huntingtin-interacting protein-1 regulates FLS invasion into matrix. This work establishes a high-resolution epigenomic landscape of RA and demonstrates the potential for integrative analyses to identify unanticipated therapeutic targets.