bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Pin-Fin Geometry on Microchannel Performance
Authors: Jadhav Subhash V. , Pawar Prashant M. , Ronge Babruvahan P. 
Published: August 2018

Abstract

Purpose
A numerical analysis is carried out to study the effect of pin fin geometry on the performance of microchannel heat sinks.

Design/methodology/approach
A three-dimensional numerical analysis is carried out using the conjugate heat transfer module of COMSOL MULTIPHYSICS software. Initially, the study is carried out for a microchannel heat sink with elliptical pin fins of 500 µm fin height, and the results of the same are validated with the results obtained from the literature. Further, the effect of different pin fin shapes and pin fin heights is investigated in terms of Nusselt number and pressure drop. The analysis is carried out with different pin fin shapes viz. ellipse, circle, square and hexagon. The pin fin height for all channels is varied from 300 µm to 700 µm. The total surface area of the channel coming into contact with coolant is kept constant for different coolant inflow velocities.

Findings
Higher values of Nusselt numbers are obtained for fin pins at larger height and high coolant inlet velocities. At coolant inlet velocity of 1 m/s, as pin fin height increases from 300 µm to 700 µm, the channel with circular pin fins shows a maximum increment of 66 % and elliptical pin fins shows a minimum increment of 40 % in terms of Nusselt number. A maximum value of Nusselt number observed is 21.36 with square pin fins of 700 µm fin height and a minimum of 6.03 Nusselt number with circular fins of 300 µm fin height.

OriginalityOriginality/Value
This study is useful in appropriate selection of pin fin geometry for enhancing the performance of microchannel heat sink.
Approximation by Max-Product Operators
Authors: Anastassiou George A. 
Published: August 2018

Abstract
Here we study the approximation of functions by a great variety of Max-Product operators under differentiability. These are positive sublinear operators. Our study is based on our general results about positive sublinear operators. We produce Jackson type inequalities under initial conditions. So our approach is quantitative by producing inequalities with their right hand sides involving the modulus of continuity of a high order derivative of the function under approximation. We improve known related results which do not use smoothness of functions..
Some New Hermite-Hadamard Type Inequalities Via k-Fractional Integrals Concerning Differentiable Generalized Relative Semi-(r;m,p,q,h1,h2)-Preinvex Mappings
Authors: Kashuri Artion , Liko Rozana 
Published: August 2018

Abstract
In this article, we first presented a new identity concerning differentiable mappings defined on m-invex set via k-fractional integrals. By using the notion of generalized relative semi-(r;m,p,q,h1,h2)-preinvexity and the obtained identity as an auxiliary result, some new estimates with respect to Hermite-Hadamard type inequalities via k-fractional integrals are established. It is pointed out that some new special cases can be deduced from main results of the article.
Pointwise Convergence of Fourier-Laguerre Series of Integrable Functions
Authors: Łenski Włodzimierz , Szal Bogdan 
Published: August 2018

Abstract
We extend and improve the some results of Xh. Z. Krasniqi [Int. J. of Anal. and Appl. Vol. 1, 33-39 (2013)], M. L. Mittal and M. V. Singh [Operators, Int. J. of Analysis, Vol. 2015, Article ID 478345, 4 pages] and from many other papers on summability of Fourier-Laguerre series to strong summability proving the estimate of the deviation of the partial sums from considered functions. There also is a remark on summability methods used in cited papers.
Opial and Pólya Type Inequalities Via Convexity
Authors: Saker S. H. , Abdou D. M. , Kubiaczyk I. 
Published: August 2018

Abstract
In this paper, we prove some new dynamic inequalities related to Opial and Pólya type inequalities on a time scale 𝕋. We will derive the integral and discrete inequalities of Pólya’s type as special cases and also derive several classical integral inequalities of Opial’s type that has been obtained in the literature as special cases. The main results will be proved by using the chain rule, Hölder’s inequality and Jensen’s inequality, Taylor formula on time scales.
The Option Value of Innovative Treatments for Metastatic Melanoma
Authors: Thornton Snider Julia , Seabury Seth , Tebeka Mahlet Gizaw , Wu Yanyu , Batt Katharine 
Published: August 2018

Abstract

Background
Treatment options in oncology have increased in recent years due to the quick pace of innovation. In the cancer care landscape, therapies that enable patients to live to the next innovation have additional value, “option value,” from the benefit of surviving to the next innovation. In such disease areas, providers and payers should consider this value when gauging the value of new therapies. The purpose of this study is to develop a model to estimate the additional survival patients attain from a therapy that allows them to live to benefit from further advances in care, and to apply the model to immunotherapy for metastatic melanoma.

Methods
The benefit of a therapy extends beyond immediate tumor control; it can also allow patients to live to benefit from further advances in care. This is a therapy’s option value. Using data from the SEER cancer registry and clinical trial publications, we developed a model to estimate option value and applied it to ipilimumab, the first immune checkpoint modulator used to treat metastatic melanoma. Because ipilimumab extends survival, select patients benefited from survival extension to live to benefit from the introduction of PD-1 inhibitors (i.e. pembrolizumab and nivolumab). We calculated the option value of ipilimumab in terms of additional life-months patients gained by living to become potential candidates for PD-1 inhibitors, discounting at 3% per year.

Results
Patients taking ipilimumab as a second-line therapy for metastatic melanoma gained 10.5 months compared to patients taking the prior standard of care. Patients diagnosed in 2011, 2012, and 2013 gained an additional 1.6, 2.8, and 5.1 months of life expectancy, respectively, by living to see the introduction of PD-1 inhibitors. This equates to an option value of 15%, 27%, and 49%, respectively, of the conventionally calculated survival gain from ipilimumab. Ipilimumab had greater option value for patients diagnosed in later years who were more likely to live to the introduction of PD-1 inhibitors.

Conclusions
Therapies that enable patients to see further advances in care have option value. Option value is particularly important to patients with disease areas undergoing rapid innovation.
The Value of the Health and Retirement Study for Health Economics Research
Authors: Coile Courtney C. , Maestas Nicole 
Published: August 2018

Abstract
We assess the value of the Health and Retirement Study (HRS) for research in health economics by conducting a survey of leading health economists. We analyze the survey responses to provide an assessment of the strengths of the HRS for this kind of research, as well as the obstacles that prevent it from being used more widely. We offer some suggestions as to how these obstacles might be overcome through changes to the survey and actions to increase survey awareness and access.
Typological variation across Mandarin dialects: An areal perspective with a quantitative approach
Authors: Szeto Pui Yiu , Ansaldo Umberto , Matthews Stephen 
Published: August 2018

AbstractThis study explores the range and diversity of the typological features of Mandarin, the largest dialect group within the Sinitic branch of the Sino-Tibetan family. Feeding the typological data of 42 Sinitic varieties into the phylogenetic program NeighborNet, we obtained network diagrams suggesting a north-south divide in the Mandarin dialect group, where dialects within the Amdo Sprachbund cluster at one end and those in the Far Southern area cluster at the other end, highlighting the impact of language contact on the typological profiles of various Mandarin dialects.
Stabilization and Analytic Approximate Solutions of an Optimal Control Problem
Authors: Pop Camelia , Petrişor Camelia , Ene Remus-Daniel 
Published: August 2018

Abstract
This paper analyses a dynamical system derived from a left-invariant, drift-free optimal control problem on the Lie group SO(3) × ℝ3 × ℝ3 in deep connection with the important role of the Lie groups in tackling the various problems occurring in physics, mathematics, engineering and economic areas [1, 2, 3, 4, 5]. The stability results for the initial dynamics were inconclusive for a lot of equilibrium points (see [6]), so a linear control has been considered in order to stabilize the dynamics. The analytic approximate solutions of the resulting nonlinear system are established and a comparison with the numerical results obtained via the fourth-order Runge-Kutta method is achieved.
New prediction method for transient productivity of fractured five-spot patterns in low permeability reservoirs at high water cut stages
Authors: Cui Chuanzhi , Wu Zhongwei , Wang Zhen , Yang Jingwei , Sui Yingfei 
Published: August 2018

AbstractPredicting the productivity of fractured five-spot patterns in low permeability reservoirs at high water cut stages has an important significance for the development and optimization of reservoirs. Taking the reservoir heterogeneity and uneven distribution of the remaining oil into consideration, a novel method for predicting the transient productivity of fractured five-spot patterns in low permeability reservoirs at high water cut stages is proposed by using element analysis, the flow tube integration method, and the mass conservation principle. This new method is validated by comparing with actual production data from the field and the results of a numerical simulation. Also, the effects of related parameters on transient productivity are analyzed. The results show that increasing fracture length, pressure difference and reservoir permeability correspond to an increasing productivity. The research provides theoretical support for the development and optimization of fractured five-spot patterns at the high water cut stage.
Microblog topic evolution computing based on LDA algorithm
Authors: Jian Feng , Yajiao Wang , Yuanyuan Ding 
Published: August 2018

AbstractResearch on topic evolution of Microblog is an effective way to analyze network public opinions. This paper proposes a method for mining changing of Microblog topics with time, and realizes topic evolution through topic extraction and topic relevance calculation. Firstly, latent Dirichlet allocation (LDA) model is used to automatically extract topics from different time slices; secondly, a similarity calculation algorithm is designed to calculate relevance of topic content through normalization of similarities among characteristic words and co-occurrence relations, to get evolutionary relationship among sub-topics of different time slices; thirdly, using probability distribution of blog article-topic to calculate topic intensity in each time slice, and then gets evolutionary relationship of topic intensity over time. Experiments show that the proposed topic evolution analysis model can effectively detect the evolution of topic content and intensity of real blogs.
On the bivariate spectral quasi-linearization method for solving the two-dimensional Bratu problem
Authors: Muzara Hillary , Shateyi Stanford , Tendayi Marewo Gerald 
Published: August 2018

AbstractIn this paper, a bivariate spectral quasi-linearization method is used to solve the highly non-linear two dimensional Bratu problem. The two dimensional Bratu problem is also solved using the Chebyshev spectral collocation method which uses Kronecker tensor products. The bivariate spectral quasi-linearization method and Chebyshev spectral collocation method solutions converge to the lower branch solution. The results obtained using the bivariate spectral quasi-linearization method were compared with results from finite differences method, the weighted residual method and the homotopy analysis method in literature. Tables and graphs generated to present the results obtained show a close agreement with known results from literature.
Yoga as a Complementary Therapy for Adults with Type 2 Diabetes: Design and Rationale of the Healthy, Active, and in Control (HA1C) Study
Authors: Thind Herpreet , Fava Joseph L. , Guthrie Kate M. , Stroud Laura , Gopalakrishnan Geetha , Sillice Marie , Gidron Naama , Bock Beth C. 
Published: August 2018

Abstract
Diabetes is the seventh leading cause of death in the United States. For most patients, medication alone is not sufficient to achieve glycemic control; attention must also be paid to multiple healthy behaviors including diet, regular physical activity, and stress management. Yoga, a mindfulness practice with emphasis on relaxation, meditation, and deep breathing, may have special relevance to people with type 2 diabetes mellitus (T2DM). Yoga practice may positively affect stress and other self-care tasks that will contribute to improved glycemic control. The Healthy, Active, and in Control (HA1C) study is designed to examine the feasibility and acceptability of yoga among adult patients with T2DM. In this pilot randomized controlled trial, adults with T2DM were randomly assigned to either a 12-week Iyengar Yoga intervention given twice weekly, or a twice-weekly 12-week program of traditional exercise (e.g., walking, stationary cycling). Assessments are conducted at the end of treatment (12 weeks) and at 3 and 6 months postintervention. The HA1C study will assess feasibility and acceptability (e.g., attendance/retention rates, satisfaction with program), glycemic outcomes (e.g., HbA1c, fasting blood glucose, postprandial blood glucose), and changes in physiological (e.g., salivary cortisol) and behavioral factors (e.g., physical activity, diet) relevant to the management of T2DM. Focus groups are conducted at the end of the intervention to explore participants' experience with the program and their perception of the potential utility of yoga for diabetes management.
FORMAÇÃO DOCENTE PARA AS ESCOLAS CIDADÃS DA PARAÍBA: CONTRIBUIÇÕES DO PROGRAMA GIRA MUNDO FINLÂNDIA
Authors: Cotrim Guimarães Iza Manuella Aires , D'Andrea Alexandre Fonseca , Ouverney King Jamylle Rebouças 
Published: August 2018

O Programa Gira Mundo Finlândia (GMF) é uma iniciativa do Governo da Paraíba, por meio da Secretaria de Estado da Educação, e tem como objetivo a capacitação de servidores efetivos da Rede Estadual de Ensino em Universidades de Ciências Aplicadas da Finlândia. Com um período de imersão entre quatro a oito semanas na Finlândia, professores e gestores visitaram escolas, organizações e vivenciaram o sistema educacional finlandês. No retorno à Paraíba, desenvolveram um projeto de aprimoramento das práticas pedagógicas nas escolas em que atuam. Este trabalho tem como objetivo analisar as contribuições do GMF para a formação docente para a EPT, especialmente pelas Escolas Cidadãs. Para tanto, foram analisados os relatórios e outros instrumentos elaborados pela coordenação do Programa a partir de seminários e atividades de acompanhamento do GMF, aplicadas aos seus participantes durante a capacitação na Finlândia e durante o desenvolvimento dos projetos aplicados nas suas escolas de origem no estado. A análise teve seu foco no perfil de competências e objetivos identificados no desenvolvimento do Programa, a partir de categorias relacionadas a: realidade Brasil x Finlândia e possibilidades de aprimoramento da Educação Brasileira; processo de ensino-aprendizagem sob a perspectiva da abordagem centrada no estudante; metodologias ativas e ferramentas digitais; práticas curriculares diferenciadas; vínculos com a comunidade e outras escolas da Paraíba. Conclui-se que o perfil das competências desenvolvidas no GMF e seus objetivos de aprendizagem relacionados permitem melhorias individuais e coletivas do processo de ensino-aprendizagem, em especial para as Escolas Cidadãs, considerando uma formação direcionada ao protagonismo juvenil.
PERSPECTIVAS (TEÓRICO)-METODOLÓGICAS PARA O CAMPO DA PESQUISA EM EDUCAÇÃO AMBIENTAL: DILEMAS E AVANÇOS NO GDP METODOLOGIA
Authors: Sumi Kawasaki Clarice , Da Cunha Teixeira Marcos 
Published: August 2018

Analisam-se as perspectivas teórico-metodológicas dos trabalhos apresentados nos Encontros de Pesquisa em Educação Ambiental (EPEA). Estas partem dos olhares e vivências dos coordenadores dos Grupos de Discussão em Pesquisa (GDP Metodologia) junto às discussões realizadas nesses grupos, cujos relatos encontram-se na forma de produções textuais, identificando-se os pontos limitantes e as potencialidades do campo metodológico da pesquisa em educação ambiental ao longo dos EPEAs. Em meio à multirreferencialidade de perspectivas presentes nesses trabalhos, problemas de natureza epistemológico-metodológica são identificados, principalmente em função de uma forte tendência em atrelar as escolhas metodológicas dos investigadores a uma pesquisa voltada para a transformação social e às perspectivas críticas e metodologias participativas como as abordagens metodológicas que melhor responderiam a essa tendência. Os dilemas envolvidos e as implicações disso para as discussões teórico-metodológicas no campo da pesquisa em EA são discutidos, trazendo avanços para as discussões no GDP Metodologia. Para além dessas questões, uma pesquisa subversiva, em consonância com uma EA subversiva, se avizinha no horizonte, trazendo novas discussões para esse cenário.
Learning the hidden structure of speech: from communicative functions to prosody
Authors: Bailly Gérard , Holm Bleike 
Published: August 2018

Este artigo introduz um novo método, orientado via modelamento e via interação com dados comportamentais, para gerar padrões prosódicos a partir de informação metalingüística. Referimos aqui à habilidade geral da entoação de demarcar unidades de fala e veicular informação sobre as funções proposicional e interacional dessas unidades no discurso. Nossas hipóteses fortes são que (1) essas funções são diretamente implementadas como contornos prosódicos prototípicos que são co-extensivos às unidades para as quais eles se aplicam, (2) o padrão prosódico da mensagem é obtido ao superpor e adicionar todos os contornos elementares (Aubergé & Bailly, 1995). Descrevemos aqui um esquema de análise por síntese que consiste em identificar esses contornos prototípicos e separar suas contribuições respectivas nos contornos prosódicos dos dados de treinamento. O esquema é aplicado a bases de dados designadas para evidenciar várias funções entoacionais. Resultados experimentais mostram que o modelo gera contornos prosódicos adequados com pouquíssimos movimentos prototípicos.
ANALISIS SIFAT OPTIK KLOROFIL PADA EKSTRAK DAUN MENGGUNAKAN UV-VIS SPEKTROMETER SEBAGAI STUDI AWAL APLIKASI DYE SENSITIZER
Authors: Dianisya Dona , Silmina Amalia Dini , Purwanto Novan , Isnaeni Isnaeni , Sugihartono Iwan 
Published: August 2018

ABSTRAK
Telah dilakukan studi ekstraksi awal klorofil dari 3 jenis daun yaitu daun bayam (Amarantus), daun pepaya (Carica papaya), dan daun jarak (Ricinus communis). Ekstraksi dilakukan dengan teknik penghancuran menggunakan blender. Pelarut yang digunakan adalah isopropanol, asam asetat, dan DI water. Hasil penyaringan ekstrak daun diperoleh larutan sebayak 75 ml untuk setiap larutan ekstrak klorofil. Uji Ultrasonic Visible memberikan konfirmasi adanya penyerapan di rentang cahaya ultraviolet dan cahaya tampak. Sementara itu, serapan klorofil teramati di rentang cahaya tampak. Apabila dibandingkan serapan UV dan cahaya tampak, pada larutan ekstrak masih mengandung banyak gugus asam dibandingkan klorofil yang di ekstrak.
Kata-kata kunci: daun bayam, daun pepaya, daun jarak, absorbansi, klorofil
ABSTRACT
We studied for chlorophyll extract from 3 leaf types that are spinach leaf (Amarantus), papaya leaf (Carica papaya), and castor leaf (Ricinus communis). The extraction is done by using a blender. The solvents used are isopropanol, acetic acid, and DI water. The result of leaf extract was obtained 75 ml solution for each solution of chlorophyll extract. The Visible Ultrasonic Test confirms absorption in the range of ultraviolet light and visible light. Meanwhile, chlorophyll uptake is observed in the visible light spectrum. When compared to UV absorption and visible light, in the extract solution still contains a lot of acid groups than the chlorophyll extracted.
Keywords: spinach leaf, papaya leaf, Castor leaf, absorbance, chlorophyll.
Molecular Design of Peptide-Fc Fusion Drugs
Authors: Ning Lin , He Bifang , Zhou Peng , Derda Ratmir , Huang Jian 
Published: August 2018

Background:Peptide-Fc fusion drugs, also known as peptibodies, are a category of biological therapeutics in which the Fc region of an antibody is genetically fused to a peptide of interest. However, to develop such kind of drugs is laborious and expensive. Rational design is urgently needed.Methods:We summarized the key steps in peptide-Fc fusion technology and stressed the main computational resources, tools, and methods that had been used in the rational design of peptide-Fc fusion drugs. We also raised open questions about the computer-aided molecular design of peptide-Fc.Results:The design of peptibody consists of four steps. First, identify peptide leads from native ligands, biopanning, and computational design or prediction. Second, select the proper Fc region from different classes or subclasses of immunoglobulin. Third, fuse the peptide leads and Fc together properly. At last, evaluate the immunogenicity of the constructs. At each step, there are quite a few useful resources and computational tools.Conclusion:Reviewing the molecular design of peptibody will certainly help make the transition from peptide leads to drugs on the market quicker and cheaper.
Long-Term Safety and Efficacy of Bapineuzumab in Patients with Mild-to-Moderate Alzheimer’s Disease: A Phase 2, Open-Label Extension Study
Authors: Salloway Stephen , Marshall Gad A. , Lu Ming , Brashear H. Robert 
Published: August 2018

Background:
Bapineuzumab is a humanized anti-amyloid-beta (Aβ) monoclonal antibody
directed at lowering the cerebral Aβ deposit in Alzheimer’s disease (AD).

Objective:

This phase 2, open-label extension (OLE) study evaluated long-term safety and efficacy of
bapineuzumab in patients with the mild-to-moderate AD.

Methods:
Patients (58-78 years) who completed either of two randomized, placebo-controlled, doubleblind
studies (subcutaneous [SC] single-dose-escalation, or intravenous (IV) multiple-ascending-dose))
entered the OLE. Three groups were assessed: bapineuzumab or placebo SC, and bapineuzumab (IV) in
OLE (bapi SC/bapi IV); bapineuzumab (IV) in Study 201 and OLE (bapi/bapi); and placebo in Study
201 and bapineuzumab IV in OLE (placebo/bapi).

Results:
Of 194 patients enrolled, 158 withdrew from OLE; primarily due to withdrawal by subject
(n=85) and AE (n=30). Mean (SD) bapineuzumab exposure was 2.9 (1.90) years. There were no significant
differences for efficacy endpoints (AD Assessment Scale–cognitive subscale [ADAS-Cog], Disability
Assessment for Dementia [DAD] and MMSE scores) between the bapi/bapi and placebo/bapi
groups. Most patients (94.8%, 184/194) reported ≥1 treatment-emergent adverse events (TEAEs) in
OLE. Amyloid-related imaging abnormalities with effusion or edema (ARIA-E) occurred in 22 (11.3%)
patients. The most common TEAEs (>20% patients) were fall, agitation and urinary tract infection with
similar incidences between bapi/bapi and placebo/bapi groups.

Conclusion:
No significant difference was seen in cognitive and functional decline between early and
delayed treatment groups. No new safety concerns emerged. ARIA-E incidence was higher in patients
first exposed to bapineuzumab in OLE versus previously exposed. No clear pattern of etiology contributed
to death events.