bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finiteness for mapping class group representations from twisted Dijkgraaf–Witten theory
Authors: Gustafson Paul P. 
Published: May 2018

We show that any twisted Dijkgraaf–Witten representation of a mapping class group of an orientable, compact surface with boundary has finite image. This generalizes work of Etingof et al. showing that the braid group images are finite [P. Etingof, E. C. Rowell and S. Witherspoon, Braid group representations from twisted quantum doubles of finite groups, Pacific J. Math. 234 (2008)(1) 33–42]. In particular, our result answers their question regarding finiteness of images of arbitrary mapping class group representations in the affirmative. Our approach is to translate the problem into manipulation of colored graphs embedded in the given surface. To do this translation, we use the fact that any twisted Dijkgraaf–Witten representation associated to a finite group [Formula: see text] and 3-cocycle [Formula: see text] is isomorphic to a Turaev–Viro–Barrett–Westbury (TVBW) representation associated to the spherical fusion category [Formula: see text] of twisted [Formula: see text]-graded vector spaces. The representation space for this TVBW representation is canonically isomorphic to a vector space of [Formula: see text]-colored graphs embedded in the surface [A. Kirillov, String-net model of Turaev-Viro invariants, Preprint (2011), arXiv:1106.6033 ]. By analyzing the action of the Birman generators [J. Birman, Mapping class groups and their relationship to braid groups, Comm. Pure Appl. Math. 22 (1969) 213–242] on a finite spanning set of colored graphs, we find that the mapping class group acts by permutations on a slightly larger finite spanning set. This implies that the representation has finite image.
The development of the manufactured gas industry in Europe
Authors: Thomas Russell 
Published: May 2018

Abstract
The manufactured gas industry was one of the great technological innovations of the industrial revolution. Whilst it was developed in Great Britain, this was not in isolation, and required the input of many European engineers, scientists and entrepreneurs for its success. Although the innovation of making inflammable gas for lighting may now seem quite simple, it brought considerable change to society. Initially, gas was used for lighting, replacing candles and oil lamps, greatly improving safety within factories by reducing the occurrence of fires. The concerns over street crime and the potential benefits of brighter gas street lights were key factors in its wider uptake. Lighting was its primary use for the first 70 years. As competition emerged from electricity, the gas industry found new markets in heat and power. Gas manufacturing also produced a range of by-products which were later found to have some very useful properties and became important feedstocks to the chemical industry. Manufactured gas was the first integrated utility energy network and its success in Britain led to a rapid spread across Europe. Since its demise and replacement by natural gas, it has left a shared but unique legacy in each country.
Deglacial sequences and glacio-isostatic adjustment: Quaternary compared with Ordovician glaciations
Authors: Dietrich Pierre , Ghienne Jean-François , Lajeunesse Patrick , Normandeau Alexandre , Deschamps Rémy , Razin Philippe 
Published: May 2018

Abstract

Deglacial sedimentary sequences recording the decay and final demise of ice sheets result from intricate interactions between the pattern of ice margin retreat, inherited basin physiography and relative sea-level (RSL) changes. A specific emphasis is here given to the glacio-isostatic adjustment (GIA), which may force postglacial local RSL fall in spite of concomitant glacio-eustatic rise. In this contribution, we characterize a Quaternary deglacial succession emplaced in such a setting, subsequently used as an analogue to interpret an end-Ordovician deglacial record. The Quaternary deglacial succession, tens of metres thick, formed under condition of RSL fall forced by the GIA in
c.
10 000 years in the aftermath of the deglaciation. This sedimentary succession consists of a lower, fining-upward sequence representing the backstepping of ice-contact depocentres following the retreat of the ice margin, and an upper, coarsening-upward sequence that relates to the subsequent progradation of a glaciofluvial delta system. A very similar stratigraphic stacking pattern characterizes the Ordovician analogue, suggesting a comparable deglacial sequence. By analogy with the Quaternary succession, this ancient deglacial record would have hence been emplaced under conditions of RSL fall forced by the GIA. Moreover, it must only represent a very short time interval that could be viewed as virtually instantaneous regarding the Late Ordovician glaciation. Such a vision is at odds with commonly accepted interpretations for such successions.
HER2 Amplification in Tumors Activates PI3K/Akt Signaling Independent of HER3
Authors: Ruiz-Saenz Ana , Dreyer Courtney , Campbell Marcia R. , Steri Veronica , Gulizia Nate , Moasser Mark M. 
Published: May 2018

Abstract
Current evidence suggests that HER2-driven tumorigenesis requires HER3. This is likely due to the unique ability of HER3 to activate PI3K/Akt pathway signaling, which is not directly accessible to HER2. By genetic elimination of HER3 or shRNA knockdown of HER3 in HER2-amplified cancer cells, we find residual HER2-driven activation of PI3K/Akt pathway signaling that is driven by HER2 through direct and indirect mechanisms. Indirect mechanisms involved second messenger pathways, including Ras or Grb2. Direct binding of HER2 to PI3K occurred through p-Tyr1139, which has a weak affinity for PI3K but becomes significant at very high expression and phosphorylation. Mutation of Y1139 impaired the tumorigenic competency of HER2. Total elimination of HER3 expression in HCC1569 HER2-amplified cancer cells significantly impaired tumorigenicity only transiently, overcome by subsequent increases in HER2 expression and phosphorylation with binding and activation of PI3K. In contrast to activation of oncogenes by mutation, activation by overexpression was quantitative in nature: weak intrinsic activities were strengthened by overexpression, with additional gains observed through further increases in expression. Collectively, these data show that progressive functional gains by HER2 can increase its repertoire of activities such as the activation of PI3K and overcome its dependency on HER3.
Significance: The intrinsic ability of HER2 to activate PI3K correlates with increased HER2 expression and can supplant the dependency upon HER3 for growth in HER2-amplified cancers. Cancer Res; 78(13); 3645–58. ©2018 AACR.
Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy
Authors: Karnes R. Jeffrey , Sharma Vidit , Choeurng Voleak , Ashab Hussam Al-Deen , Erho Nicholas , Alshalalfa Mohammed , Trock Bruce , Ross Ashley , Yousefi Kasra , Tsai Harrison , Zhao Shuang G. , Tosoian Jeffrey J. , Haddad Zaid , Takhar Mandeep , Chang S. Laura , Spratt Daniel E. , Abdollah Firas , Jenkins Robert B. , Klein Eric A. , Nguyen Paul L. , Dicker Adam P. , Den Robert B. , Davicioni Elai , Feng Felix Y. , Lotan Tamara L. , Schaeffer Edward M. 
Published: May 2018

Abstract
Purpose: Currently, no genomic signature exists to distinguish men most likely to progress on adjuvant androgen deprivation therapy (ADT) after radical prostatectomy for high-risk prostate cancer. Here we develop and validate a gene expression signature to predict response to postoperative ADT.
Experimental Design: A training set consisting of 284 radical prostatectomy patients was established after 1:1 propensity score matching metastasis between adjuvant-ADT (a-ADT)-treated and no ADT–treated groups. An ADT Response Signature (ADT-RS) was identified from neuroendocrine and AR signaling–related genes. Two independent cohorts were used to form three separate data sets for validation (set I, n = 232; set II, n = 435; set III, n = 612). The primary endpoint of the analysis was postoperative metastasis.
Results: Increases in ADT-RS score were associated with a reduction in risk of metastasis only in a-ADT patients. On multivariable analysis, ADT-RS by ADT treatment interaction term remained associated with metastasis in both validation sets (set I: HR = 0.18, Pinteraction = 0.009; set II: HR = 0.25, Pinteraction = 0.019). In a matched validation set III, patients with Low ADT-RS scores had similar 10-year metastasis rates in the a-ADT and no-ADT groups (30.1% vs. 31.0%, P = 0.989). Among High ADT-RS patients, 10-year metastasis rates were significantly lower for a-ADT versus no-ADT patients (9.4% vs. 29.2%, P = 0.021). The marginal ADT-RS by ADT interaction remained significant in the matched dataset (Pinteraction = 0.035).
Conclusions: Patients with High ADT-RS benefited from a-ADT. In combination with prognostic risk factors, use of ADT-RS may thus allow for identification of ADT-responsive tumors that may benefit most from early androgen blockade after radical prostatectomy. We discovered a gene signature that when present in primary prostate tumors may be useful to predict patients who may respond to early ADT after surgery. Clin Cancer Res; 24(16); 3908–16. ©2018 AACR.
Genomic Heterogeneity and the Small Renal Mass
Authors: Ueno Daiki , Xie Zuoquan , Boeke Marta , Syed Jamil , Nguyen Kevin A. , McGillivray Patrick , Adeniran Adebowale , Humphrey Peter , Dancik Garrett M. , Kluger Yuval , Liu Zongzhi , Kluger Harriet , Shuch Brian 
Published: May 2018

Abstract
Purpose: Tumor heterogeneity may represent a barrier to preoperative genomic characterization by needle biopsy in clear cell renal cell carcinoma (ccRCC). The extent of heterogeneity in small renal tumors remains unknown. Therefore, we set out to evaluate heterogeneity in resected large and small renal tumors.
Experimental Design: We conducted a study from 2013 to 2016 that evaluated 47 consecutive ccRCC tumors resected during radical or partial nephrectomy. Cases were designated as small (&lt;4 cm) and large (&gt;7 cm) tumors. Each tumor had three regions sampled. Copy-number variation (CNV) was assessed and gene expression analysis was performed to characterize the clear-cell A and B (ccA/ccB) profile and the cell-cycle progression (CCP) score. Genomic heterogeneity between three regions was evaluated using CNV subclonal events, regional expression profiles, and correlation between gene expression.
Results: Twenty-three small and 24 large tumors were analyzed. Total CNVs and subclonal CNVs events were less frequent in small tumors (P &lt; 0.001). Significant gene expression heterogeneity was observed for both CCP scores and ccA/ccB classifications. Larger tumors had more variance in CCP scores (P = 0.026). The distribution of ccA/ccB differed between small and large tumors with mixed ccA/ccB tumors occurring more frequently in the larger tumors (P = 0.024). Analysis of five mixed tumors (with both ccA/ccB regions) demonstrated the more aggressive ccB phenotype had greater CNV events (P = 0.014).
Conclusions: Small renal tumors have much less genomic complexity and fewer subclonal events. Pretreatment genomic characterization with single-needle biopsy in small tumors may be useful to assess biologic potential and may influence therapy. Clin Cancer Res; 24(17); 4137–44. ©2018 AACR.
Transient Telomerase Inhibition with Imetelstat Impacts DNA Damage Signals and Cell-Cycle Kinetics
Authors: Thompson Connor A.H. , Gu Alice , Yang Sunny Y. , Mathew Veena , Fleisig Helen B , Wong Judy M.Y. 
Published: May 2018

Abstract
Telomerase is the ribonucleoprotein reverse transcriptase that catalyzes the synthesis of telomeres at the ends of linear chromosomes and contributes to proper telomere-loop (T-loop) formation. Formation of the T-loop, an obligate step before cell division can proceed, requires the generation of a 3′-overhang on the G-rich strand of telomeric DNA via telomerase or C-strand specific nucleases. Here, it is discovered that telomerase activity is critical for efficient cell-cycle progression using transient chemical inhibition by the telomerase inhibitor, imetelstat. Telomerase inhibition changed cell cycle kinetics and increased the proportion of cells in G2-phase, suggesting delayed clearance through this checkpoint. Investigating the possible contribution of unstructured telomere ends to these cell-cycle distribution changes, it was observed that imetelstat treatment induced γH2AX DNA damage foci in a subset of telomerase-positive cells but not telomerase-negative primary human fibroblasts. Chromatin-immunoprecipitation with γH2AX antibodies demonstrated imetelstat treatment-dependent enrichment of this DNA damage marker at telomeres. Notably, the effects of telomerase inhibition on cell cycle profile alterations were abrogated by pharmacological inhibition of the DNA-damage-repair transducer, ATM. Also, imetelstat potentiation of etoposide, a DNA-damaging drug that acts preferentially during S–G2 phases of the cell cycle, depends on functional ATM signaling. Thus, telomerase inhibition delays the removal of ATM-dependent DNA damage signals from telomeres in telomerase-positive cancer cells and interferes with cell cycle progression through G2.
Implications: This study demonstrates that telomerase activity directly facilitates the progression of the cell cycle through modulation of transient telomere dysfunction signals. Mol Cancer Res; 16(8); 1215–25. ©2018 AACR.
Secondary Prevention Three and Six Years after Stroke Using the French National Insurance Healthcare System Database
Authors: Mechtouff Laura , Haesebaert Julie , Viprey Marie , Tainturier Valérie , Termoz Anne , Porthault-Chatard Sylvie , David Jean-Stéphane , Derex Laurent , Nighoghossian Norbert , Schott Anne-Marie 
Published: May 2018

<b><i>Background:</i></b> Secondary prevention is inadequate in the first 2 years after stroke but what happens after that is less documented. The aim of this study was to assess the use and the adherence to preventive drugs 3 and 6 years after experiencing a transient ischemic attack (TIA) or an ischemic stroke (IS). <b><i>Methods:</i></b> The population study was from the AVC69 cohort (IS or TIA admitted in an emergency or stroke unit in the Rhône area, France, for an IS or a TIA during a 7-month period). Medication use was defined as ≥1 purchase during the studied year and adherence as Continuous Measure of Medication Acquisition ≥0.8 using the French medical insurance health care funding database. <b><i>Results:</i></b> The study population consisted of 210 patients at 3 years and 163 patients at 6 years. Medication use at 3 and 6 years was, respectively, 80.9 and 79.8% for antithrombotics, 69.1 and 66.3% for antihypertensives, 60.5 and 55.2% for statins and 48.6 and 46.6% for optimal treatment defined as the treatment achieved by the use of the 3 drugs. Adherence to each class was good at 3 years and tends to decrease at 6 years. <b><i>Conclusions:</i></b> More than one patient out of 2 do not use the optimal preventive treatment.
Early Blood–Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules
Authors: Hoffmann Angelika , Dege Tassilo , Kunze Reiner , Ernst Anne-Sophie , Lorenz Holger , Böhler Laura-Inés , Korff Thomas , Marti Hugo H. , Heiland Sabine , Bendszus Martin , Helluy Xavier , Pham Mirko 
Published: May 2018

Background and Purpose—
Detection and localization of the early phase of blood–brain barrier disruption (BBBD) in vivo during cerebral ischemia/reperfusion injury remain a major challenge but may be a relevant outcome parameter in stroke.

Methods—
We studied early BBBD in mice after transient middle cerebral artery occlusion by multimodal, high-field (9.4T) in vivo magnetic resonance imaging, including the contrast agent gadofluorineM as an albumin-binding tracer. GadofluorineM contrast-enhanced magnetic resonance imaging was performed to determine BBBD at 2, 6, and 24 hours after reperfusion. BBBD was confirmed and localized along the microvascular tree by using fluorescent gadofluorineM and immunofluorescence stainings (cluster of differentiation 31, ephrin type-B receptor 4, alpha smooth muscle actin, ionized calcium binding adaptor molecule 1).

Results—
GadofluorineM contrast-enhanced magnetic resonance imaging revealed a multifocal spatial distribution of early BBBD and its close association with the microvasculature at a resolution of 40 μm. GadofluorineM leakage was closely associated with ephrin type-B receptor 4-positive but not alpha smooth muscle actin-positive vessels. The multifocal pattern of early BBBD (already at 2 hours after reperfusion) thus occurred in the distal capillary and venular microvascular bed. These multifocal zones showed distinct imaging signs indicative of early vasogenic edema. The total volume of multifocal early BBBD accurately predicted infarct size at 24 hours after reperfusion.

Conclusions—
Early BBBD in focal cerebral ischemia initiates multifocally in the distal capillary and venular bed of the cerebral microvasculature. It is closely associated with perimicrovascular vasogenic edema and microglial activation and predicts the extent of final infarction.
Praise of the Prophet and Praise of Self: Sīrat Banī Hilāl and Epic Narrative in Performance
Authors: Slyomovics Susan 
Published: May 2018

Abstract
How does an epic begin in performance and in narration? Questions surrounding the beginning of an Arab oral epic performance differ from those surrounding the origins of the text. This essay explores several levels of beginning in the Sīrat Banī Hilāl epic, a cycle of heroic tales recited throughout the Arabic and Amazigh-speaking world, with reference to versions by the oral epic poet ʿAwaḍ Allāh ʿAbd al-Jalīl ʿAlī that I collected in Upper Egypt in the 1980s. By drawing on the writings of Pierre Cachia, a pioneering scholar in the study, transcription, and English translation of vernacular Arabic literature, I ask how the epic poet begins reciting an epic in performance and how the epic hero is born in text, performance, and scholarly histories. Answers may be found both in the history of Egyptian folklore studies and the tradition of praise-poetry (madīḥ) sung or recited by poets and storytellers to initiate oral epic performance.
“An Oriental Orientalist”: Aḥmad Zakī Pasha (1868-1934), Egyptian Statesman and Philologist in the Colonial Age
Authors: Ryad Umar 
Published: May 2018

AbstractThe article sheds light on an important episode of the Arab-Orientalist encounter in the late nineteenth and early twentieth century by highlighting the role of the Egyptian scholar Aḥmad Zakī Pasha (1868-1934) in Orientalist circles, his travels to Europe, and his contributions to Arabic linguistic and cultural revival as well as politics. The study looks at his contribution as a member of the international scholarly circles of Arabic and Islamic studies. It will be shown that his engagement with European Orientalists was inseparable from his endeavors to ‘revive’ the Arabic heritage (iḥyā’ al-turāth), an engagement that was rooted in his discourse of ‘Arabism’ (al-‘urūba).
Tracheoesophageal Prosthesis Use Is Associated With Improved Overall Quality of Life in Veterans With Laryngeal Cancer
Authors: Patel Ramya S. , Mohr Tiffany , Hartman Christine , Stach Carol , Sikora Andrew G. , Zevallos Jose P. , Sandulache Vlad C. 
Published: May 2018

Objectives: Veterans have an increased risk of laryngeal cancer, yet their oncologic and functional outcomes remain understudied. We sought to determine the longitudinal impact of tracheoesophageal puncture and voice prosthesis on quality-of-life measures in veterans following total laryngectomy (TL). Methods: We performed a cross-sectional analysis of TL patients (n = 68) treated at the Michael E. DeBakey Veterans Affairs Medical Center using the Voice Handicap Index (VHI), MD Anderson Dysphagia Index (MDADI), and University of Washington Quality of Life Index (UW-QOL). Results: Using tracheoesophageal (TE) speech was associated with significantly better VHI, MDADI, and UW-QOL scores compared to other forms of communication. The association between TE speech use on VHI, MDADI, and UQ-QOL persisted even when the analysis was limited to patients with >5-year follow-up and was maintained on multivariate analysis that accounted for a history of radiation and laryngectomy for recurrent laryngeal cancer. Conclusions: Using tracheoesophageal speech after total laryngectomy is associated with durable improvements in quality of life and functional outcomes in veterans. Tracheoesophageal voice restoration should be attempted whenever technically feasible in patients that meet the complex psychosocial and physical requirements to appropriately utilize TE speech.
Stuttering Frequency, Speech Rate, Speech Naturalness, and Speech Effort During the Production of Voluntary Stuttering
Authors: Davidow Jason H. , Grossman Heather L. , Edge Robin L. 
Published: May 2018

Purpose: Voluntary stuttering techniques involve persons who stutter purposefully interjecting disfluencies into their speech. Little research has been conducted on the impact of these techniques on the speech pattern of persons who stutter. The present study examined whether changes in the frequency of voluntary stuttering accompanied changes in stuttering frequency, articulation rate, speech naturalness, and speech effort. Method: In total, 12 persons who stutter aged 16–34 years participated. Participants read four 300-syllable passages during a control condition, and three voluntary stuttering conditions that involved attempting to produce purposeful, tension-free repetitions of initial sounds or syllables of a word for two or more repetitions (i.e., bouncing). The three voluntary stuttering conditions included bouncing on 5%, 10%, and 15% of syllables read. Friedman tests and follow-up Wilcoxon signed ranks tests were conducted for the statistical analyses. Results: Stuttering frequency, articulation rate, and speech naturalness were significantly different between the voluntary stuttering conditions. Speech effort did not differ between the voluntary stuttering conditions. Stuttering frequency was significantly lower during the three voluntary stuttering conditions compared to the control condition, and speech effort was significantly lower during two of the three voluntary stuttering conditions compared to the control condition. Conclusions: Due to changes in articulation rate across the voluntary stuttering conditions, it is difficult to conclude, as has been suggested previously, that voluntary stuttering is the reason for stuttering reductions found when using voluntary stuttering techniques. Additionally, future investigations should examine different types of voluntary stuttering over an extended period of time to determine their impact on stuttering frequency, speech rate, speech naturalness, and speech effort.