bluuebunny/crossref_metadata_2025_split huggingface dataset:
Same‐Day Discharge After Uncomplicated Transcatheter Tricuspid Valve‐In‐Valve Implantation
Authors: Chan Joseph Mun Hoong , Anderson Jason H. , Hagler Donald J. , Cabalka Allison K. , Taggart Nathaniel W. 
Published: December 2024

ABSTRACTBackgroundTricuspid valve‐in‐valve (TVIV) implantation has traditionally included post‐procedure overnight in‐hospital observation with next‐day discharge. Recently, our practice has shifted toward same‐day discharge for most patients after vascular access site hemostasis and adequate recovery from anesthesia. However, data on the safety of this approach remains scarce.AimsOur study aims to describe our practice change and to identify factors that may lead to overnight observation post‐TVIV.MethodsWe retrospectively reviewed medical records of patients who underwent uncomplicated TVIV implantation as an outpatient procedure at Mayo Clinic between 2011 and 2023.ResultsOf the 83 patients who underwent TVIV from 2011 to 2023, 65 (78%) were included in the study. The first 39 patients in our institutional series were observed overnight as standard practice. 18 (69%) of the most recent 26 patients in our series were discharged the same day; three patients who remained in the hospital overnight were because of provider preference and/or patient preference without any specific medical concern. Of all 47 patients who were observed overnight, one patient was treated for fluid overload, one patient had non‐sustained ventricular tachycardia on telemetry that resulted in adjustment of antiarrhythmic therapy, two patients had continued bleeding from the access sites and was observed for another day. Among the two of them, one also developed atrial tachyarrhythmias requiring initiation of additional antiarrhythmic therapy. Out of 18 patients discharged the same day, one patient had an ED presentation within 24 h due to access site bleeding which was resolved promptly. There was no mortality or procedural‐related readmission.ConclusionSame‐day discharge may be considered for adult patients who have undergone uncomplicated TVIV with adequate hemostasis and recovery after anesthesia.
Pacing‐Induced Cardiomyopathy in a Patient With a Leadless Pacemaker Following Transcatheter Aortic Valve Replacement
Authors: Ko Euihong , Isotani Akihiro , Shirai Shinichi , Ando Kenji 
Published: December 2024

ABSTRACTConduction disturbances following transcatheter aortic valve replacement (TAVR) sometimes require permanent pacemaker implantation. However, little is known about the pacing‐induced cardiomyopathy (PICM) in leadless pacemaker (LP) after TAVR. Here we present a case of heart failure due to PICM 6 months after TAVR which was successfully treated with LOT‐CRT upgrade.
A Rare Case of Granular Cell Tumor of the Anus
Authors: Mehta C. H. , Kantzler E. J. , Suzuki M. , Honaker M. D. 
Published: December 2024

ABSTRACTGranular cell tumors (GCTs) are uncommon soft tissue neoplasms derived from Schwann cells that can arise from various regions of the body. The majority originate from the head and neck. They are rarely encountered in the gastrointestinal tract and even more rarely in the anorectal region. There is a paucity of literature with only a few case reports of GCT of the anus. We describe a 36‐year‐old African American male with a long‐standing history of human immunodeficiency virus (HIV) infection, multiple perianal abscess and associated fistulas, and an ulcerated perianal lesion that revealed an anal GCT who was treated with excision and surveillance. Given that GCTs in the perianal region are extremely rare, a high index of suspicion of GCT of the anus is critical when patients present with anal masses, ulcers, or abscesses given the extremely poor prognosis of malignant GCTs.
18F‐FAPI versus 18F‐FDG PET/CT in the Diagnosis of Relapsing Polychondritis
Authors: Guo Xiaotong , Chen Juan , Zhao Qian , Liu Ying , Wang Xiuyan 
Published: December 2024

ABSTRACTRelapsing polychondritis (RP) is a rare immune‐mediated systemic inflammatory disease with diverse clinical manifestations. Independent involvement of the respiratory system in RP is uncommon. In the event of respiratory involvement as the initial airway‐only manifestation, the diagnosis of RP is challenging and might be delayed, and patients with respiratory involvement exhibit a poor prognosis. However, no specific diagnostic method is currently available for RP with respiratory system involvement as the main clinical manifestation. We present a 49‐year‐old female with the complaint of chronic dry cough accompanied by shortness of breath after exercise that has persisted for over a year. The patient was treated using corticosteroids. The patient's symptoms improved rapidly with the administration of 5 days of methylprednisolone sodium succinate at a dose of 40 mg/day. The treatment was then switched to methylprednisolone tablets at a dose of 40 mg/day, and the dosage was reduced by 4 mg every week until the cessation of therapy. Meanwhile, oral cyclophosphamide tablets were administered once every day at a dose of 100 mg each time. After 1 month of treatment, the symptoms of cough disappeared, the modified british medical research council (mMRC) grade dropped from 4 to 2, and the COPD assessment test (CAT) score dropped from 30 to 17. Repeated CT of the chest revealed that the tracheal wall thickening had alleviated. No recurrence was revealed in the follow‐up visit 12 months after drug withdrawal. The patient underwent 18F‐FDG PET/CT examination before hormone and immunosuppressive therapy, and 18F‐FAPI PET/CT examination was performed 5 days later. The 18F‐FDG PET/CT method revealed slight thickening of the local wall of the trachea and the left and right main bronchus, with no increase in the FDG metabolism, and no abnormalities in the rest of the cartilage. 18F‐FAPI PET‐CT imaging showed increased FAPI uptake in various parts of the body, including trachea and bronchus. The present study reports that compared to 18F‐FDG PET/CT, the 18F‐FAPI PET/CT revealed more lesions and provided a better image contrast, suggesting the latter as a suitable diagnostic method for RP, which could assist in improving the clinical management of RP patients.
Prolonged Hypoglycemic Encephalopathy: A Case Report
Authors: Shah Newton Ashish , Bastola Santosh , Shah Abhishek Kumar , Yadav Manish 
Published: December 2024

ABSTRACTHypoglycemic encephalopathy is a rare yet life‐threatening diabetes complication, where overlapping symptoms with neurological conditions can delay diagnosis. Early recognition and treatment are crucial to prevent irreversible brain damage. Clinicians should suspect hypoglycemia in diabetic patients with altered mental status, as timely intervention improves outcomes and reduces mortality.
One‐Step Hydrothermal Synthesis of Glucose‐Induced Low Crystallinity NiCo‐Based Layered Double Hydroxides for High‐Performance Asymmetric Supercapacitors
Authors: Cheng Xiaoyang , Zhang Lihua , Li Lingyan , Wu Hao , Zheng Jinfeng , Sun Jiao , Li Guifang 
Published: December 2024

AbstractIn order to improve the electrochemical performance of NiCo‐based layered double hydroxide (NiCoLDH), the synthesis of low‐crystallinity NiCoLDH was induced by the adsorption of glucose and NiCoLDH. The results showed that glucose could not only effectively regulate the pore structure and morphology of NiCoLDH, but also had a regular effect on crystallinity. Pure phase NiCoLDH had higher crystallinity. When the mass of glucose is 0.05 g, the prepared NiCoLDH‐0.05 is a short‐range ordered structure embedded in the amorphous matrix. The crystallinity of the product decreases further with the further increase of glucose mass. Since the ordered structures have higher electrical conductivity, and amorphous structures have more defects and active sites, the structure of NiCoLDH‐0.05 is conducive to achieving the best electrochemical performance. Electrochemical test results show that NiCoLDH‐0.05 has a high specific capacitance, about 12 times that of the pure phase NiCoLDH, the mass of glucose is higher than or below 0.05 g, the specific capacitance will be further reduced. NiCoLDH‐0.05 and activated carbon assembled into an asymmetric supercapacitor have a power density of 400 W kg−1 at an energy density of 32.7 Wh kg−1. This study provides a new idea for obtaining excellent electrochemical properties by adjusting LDH crystallinity.
A genome‐wide association study identifies eight loci associated with intraductal papillary mucinous neoplasm progression toward malignancy
Authors: Gentiluomo Manuel , Corradi Chiara , Apadula Laura , Comandatore Annalisa , Lauri Gaetano , Rossi Gemma , Peduzzi Giulia , Crippa Stefano , Rizzato Cosmeri , Falconi Massimo , Arcidiacono Paolo Giorgio , Morelli Luca , Capurso Gabriele , Campa Daniele 
Published: December 2024

AbstractBackgroundIntraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer, but not all IPMNs progress to cancer. The objective of this study was to identify the germline genetic variants associated with IPMN clinical progression by conducting the first genome‐wide association study (GWAS) and computing a polygenic hazard score (PHS) in 338 patients with IPMN.MethodsThe study population was divided into two subsets, and a Cox analysis adjusted for sex, age, cyst size at diagnosis, and the top 10 principal components was performed. A PHS was calculated using the genotypes of common variants associated with IPMN progression identified.ResultsEight loci with significant associations (p < 5 × 10−8) were identified, and the most significant was 7q21.11‐rs117620617 (hazard ratio, 16.35; 95% confidence interval, 6.93–38.60; p = 1.80 × 10−10). All variants were associated with inflammatory processes, suggesting that alleles that predispose to an inflammatory prone phenotype may promote progression. The PHS indicated a statistically significant association (hazard ratio, 18.05; 95% confidence interval, 7.96–45.80; p = 6.18 × 10−11) with IPMN progression among individuals who had the highest number of effect alleles (fourth quartile) compared with those who had the lowest number (first quartile).ConclusionsThe current results study advance the understanding of individual predisposition to IPMN progression and underscore the potential use of genetics in the stratification of patients who have IPMN.
An Inflammation‐Related lncRNA Signature for Prognostic Prediction in Colorectal Cancer
Authors: Zhang Zhenling , Luo Yingshu , Liu Yuan , Ren Jiangnan , Fang Zhaoxiong , Han Yanzhi 
Published: December 2024

ABSTRACTBackgroundColorectal cancer (CRC) represents a commonly diagnosed malignancy affecting the digestive system. Mounting evidence shows long noncoding RNAs (lncRNAs) contribute to carcinogenesis. However, inflammation‐related lncRNAs (IRLs) regulating CRC are poorly defined.AimsThe current study aimed to develop an IRL signature for predicting prognosis in CRC and to examine the involved molecular mechanism.Methods and ResultsRNA‐seq findings and patient data were retrieved from The Cancer Genome Atlas (TCGA), and inflammation‐associated genes were obtained from the GeneCards database. IRLs with differential expression were determined with “limma” in R. Using correlation and univariable Cox analyses, prognostic IRLs were identified. The least absolute shrinkage and selection operator (LASSO) algorithm was employed to construct a prognostic model including 13 IRLs. The model's prognostic value was examined by Kaplan–Meier (K‐M) survival curve and receiver operating characteristic (ROC) curve analyses. Furthermore, the association of the signature with the immune profile was assessed. Finally, RT‐qPCR was carried out for verifying the expression of inflammation‐related lncRNAs in nonmalignant and malignant tissue samples. A model containing 13 inflammation‐related lncRNAs was built and utilized to classify cases into two risk groups based on risk score. The signature‐derived risk score had a higher value in predicting survival compared with traditionally used clinicopathological properties in CRC cases. In addition, marked differences were detected in immune cells between the two groups, including CD4+ T cells and M2 macrophages. Furthermore, RT‐qPCR confirmed the expression patterns of these 13 lncRNAs were comparable to those of the TCGA‐CRC cohort.ConclusionThe proposed 13‐IRL signature is a promising biomarker and may help the clinical decision‐making process and improve prognostic evaluation in CRC.
Molecular mechanisms underlying oesophageal cancer development triggered by chronic alcohol consumption
Authors: Chen Huai Yi , Por Chia Rou , Hong Yong Kai , Kong Eason Qi Zheng , Subramaniyan Vetriselvan 
Published: December 2024

AbstractThis review explores the mechanisms underlying alcohol‐induced oesophageal carcinogenesis, including DNA damage, oxidative stress, and nutritional deficiencies. Alcohol metabolism primarily involves alcohol dehydrogenase (ADH) converting ethanol to acetaldehyde, which can cause DNA damage, inhibit repair mechanisms, and form DNA adducts thus inhibiting DNA replication. Plus, it delves into the epidemiological evidence, genetic susceptibility, epigenetic modifications, biomarkers, and preventive strategies associated with alcohol‐related oesophageal cancers. Consumption of alcohol increases the risk of gastroesophageal reflux disease thus compromising mucosal integrity of the oesophagus as dysregulation of cytokines such as IL‐18, TNFA, GATA3, TLR4, and CD68 expands the intercellular spaces of epithelial cells. Genetic variants, such as ADH1B rs1229984 and ALDH2 rs671, significantly influence susceptibility to alcohol‐related oesophageal cancers, with these variations affecting acetaldehyde metabolism and cancer risk. Understanding these factors is crucial for early detection, effective treatment, and the development of targeted prevention strategies. Biomarkers, such as miRNA and metabolite markers, offer non‐invasive methods for early detection, while advanced endoscopic techniques provide better diagnostic accuracy. Pharmacological interventions, such as statins and proton pump inhibitors, also show potential for reducing cancer progression in high‐risk individuals. Despite advances, late‐stage oesophageal cancer diagnoses are still common, highlighting the need for better screening and prevention. Further research, including this study, should aim to improve early detection, personalise prevention, and explore new treatments to reduce cases and enhance outcomes in alcohol‐related oesophageal cancers.
Unveiling the effects of landscape–fire interactions on functional diversity in a Southern European mountain
Authors: Campos João C. , Albuquerque Beatriz , Civantos Emilio , Honrado João P. , Regos Adrián 
Published: December 2024

AbstractClimate and land‐use changes are contributing to impacts on global ecosystem functioning. These effects are particularly severe in areas undergoing land abandonment and extreme wildfire events, such as the Mediterranean regions of the Iberian Peninsula. Previous studies have evaluated the impacts of land management on fire mitigation and biodiversity (species distribution and species richness), but how such strategies influence functional diversity remains unexplored. This study investigates how alternative land‐fire management strategies may affect functional diversity. We modeled for 2050 for the Transboundary Biosphere Reserve Gerês‐Xurés (Portugal‐Spain). Land‐use scenarios simulated processes of land abandonment (“business‐as‐usual”—BAU) and the implementation of EU rural policies (“high nature value farmlands”—HNVf), and were combined with three fire suppression levels. Species distribution models (102 vertebrates) were projected to each scenario, and functional diversity indices were consequently calculated. The highest functional richness was predicted for BAU scenarios, probably representing the benefits to unique species that deliver singular functions. The HNVf scenarios provided the highest functional divergence, probably indicating a high niche differentiation and low resource competition amongst agricultural communities. HNVf was the most beneficial scenario for ecosystem functioning, while fire suppression did not affect functional diversity. Despite the proneness to burn of our study area and the effects of firefighting on its fire regime, land‐use policies are expected to have greater influence than fire suppression effects on functional diversity. These findings suggest that different facets of functional diversity will be unevenly influenced by fire–landscape dynamics driven by the land‐use policies to be implemented in the upcoming decades.
Individuality Through Ecology: Rethinking the Evolution of Complex Life From an Externalist Perspective
Authors: Bourrat Pierrick , Takacs Peter , Doulcier Guilhem , Nitschke Matthew C. , Black Andrew J. , Hammerschmidt Katrin , Rainey Paul B. 
Published: December 2024

ABSTRACTThe evolution of complex life forms, exemplified by multicellular organisms, can be traced through a series of evolutionary transitions in individuality, beginning with the origin of life, followed by the emergence of the eukaryotic cell, and, among other transitions, culminating in the shift from unicellularity to multicellularity. Several attempts have been made to explain the origins of such transitions, many of which have been internalist (i.e., based largely on internal properties of ancestral entities). Here, we show how externalist perspectives can shed new light on questions pertaining to evolutionary transitions in individuality. We do this by presenting the ecological scaffolding framework in which properties of complex life forms arise from an external scaffold. Ultimately, we anticipate that progress will come from recognition of the importance of both the internalist and externalist modes of explanation. We illustrate this by considering an extension of the ecological scaffolding model in which cells modify the environment that later becomes the scaffold giving rise to multicellular individuality.
Extensive Tracking of Nomadic Waterbird Movements Reveals an Inland Flyway
Authors: McGinness Heather M. , Jackson Micha V. , Lloyd‐Jones Luke , Robinson Freya , Langston Art , O'Neill Louis G. , Rapley Shoshana , Piper Melissa , Davies Micah , Hodgson Jessica , Martin John M. , Kingsford Richard , Brandis Kate , Doerr Veronica , Mac Nally Ralph 
Published: December 2024

ABSTRACTWaterbirds are highly mobile and have the ability to respond to environmental conditions opportunistically at multiple scales. Mobility is particularly crucial for aggregate‐nesting species dependent on breeding habitat in arid and semi‐arid wetlands, which can be ephemeral and unpredictable. We aimed to address knowledge gaps about movement routes for aggregate‐nesting nomadic waterbird species by tracking them in numbers sufficient to make robust assessment of their movement patterns. We hypothesised that analysis of long‐distance movements would identify common routes with consistent environmental features that would be useful as context for conservation management. We used GPS satellite telemetry to track the movements of 73 straw‐necked ibis (Threskiornis spinicollis) and 42 royal spoonbills (Platalea regia) over 7 years (2016‐2023). We used these data to identify long‐distance movements and to demarcate and characterise movement routes. We identified common routes used by both species, including a ‘flyway’ over 2000 km long, spanning Australia's Murray–Darling Basin from the south‐west to the north‐east. This flyway connects important breeding sites and is characterised by flat, open/unforested areas with low elevations of < 350 m and mid to high rainfall. The flyway corresponds to an area west of Australia's Great Dividing Range, which appears to act as a low‐permeability barrier to the movement of both species. Identification of an inland flyway for waterbirds in Australia provides important context for multi‐jurisdictional cooperation and strategic management. Where resources are limited, water and wetland management efforts (e.g., environmental watering) should be preferentially located within this route. Similarly, targeting threat mitigation within common movement routes may have disproportionate importance for long‐term population viability. Given the widespread distribution of similar species globally, there are likely to be other flyways worthy of scientific and conservation management attention that could be identified using our approach.
The Origin of the Matter Matters: The Influence of Terrestrial Inputs on Coastal Benthic Microeukaryote Communities Revealed by eDNA
Authors: Meyneng Mathisse , Siano Raffaele , Mouras Naïna , Ansquer Dominique , Laporte‐Magoni Christine , Antypas Florence , Haize Thomas , Lemonnier Hugues 
Published: December 2024

ABSTRACTEstuaries are a key component of the land‐sea continuum, and their microbial diversity depends on the connection with terrestrial ecosystems. This work aimed to demonstrate that the terrestrial matter carried by rivers influences the structuration of microeukaryote communities of superficial (0–3 cm) sediments collected at the interface between the land and marine coastal areas. To demonstrate this hypothesis, we have chosen the main island of New Caledonia as a study site, a French overseas territory located in the South West Pacific. Using amplicon sequencing of the 18S‐V4 rDNA extracted from sediments, we analyzed microeukaryote community composition in relation to numerous environmental parameters. Samples were collected in five bays influenced by riverine inputs and corresponding to distinct geological features of the watersheds, as revealed by high variations in metal concentrations released from specific minerals in the sediment. Particularly, the influence of ultramafic soils was highlighted by higher nickel concentration (correlated to Co, Cr, Mn, and Fe). Diatoms were the dominant taxonomic group, especially the classes of Bacillariophyceae and Mediophyceae. Then Apicomplexa, Ciliophora, Dinoflagellata, and Cercozoa followed. The metallic composition of the sediment explained 18.46% of the community spatial variability. The selection of ASVs based on their contribution to beta diversity and their correlation with metallic concentrations enabled us to identify spatial patterns. This information could lead to identifying microeukaryote bioindicators of terrestrial influences, particularly of ultramafic origin. We hypothesized that the association between microeukaryotes and metallic compositions is linked to selection processes, given the resistance of some microeukaryotes to some high metallic concentrations. In vitro experiments are needed to confirm this hypothesis. Our results emphasized the role of terrestrial inputs in shaping estuarine diversity and the need to consider the entire land–sea continuum for studying these ecosystems.