bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risks of hospitalization for upper gastrointestinal bleeding in users of selective serotonin reuptake inhibitors after Helicobacter pylori eradication therapy: a propensity score matching analysis
Authors: Guo Chuan‐Guo , Cheung Ka Shing , Zhang Feifei , Chan Esther W. , Chen Lijia , Wong Ian C. K. , Leung Wai K. 
Published: October 2019

SummaryBackgroundSelective serotonin reuptake inhibitors (SSRIs) are the first‐line treatment for depression but there is a concern about the risk of upper gastrointestinal bleeding (UGIB). Past studies, however, are largely confounded by the presence of Helicobacter pylori (HP).AimTo evaluate the UGIB risk of SSRI users after treatment for HP.MethodsThis was a propensity score (PS) matched cohort study with patients who used SSRI after receiving HP eradication therapy from the Hong Kong territory‐wide healthcare database. The primary outcome was hospitalisation for nonvariceal UGIB. PS matching analysis with a ratio of 1:2 plus Cox regression model was used to compute the hazards ratios (HR) and 95% CI of UGIB risk.ResultsIn this study, 3358 SSRI users and 57 906 non‐users were included. The median follow‐up duration was 7.74 (interquartile range 5.32‐10.42) years. The crude incidence of hospitalisation for UGIB was 3.98 (95% CI 3.80‐4.16) per 1000 person‐years. In the PS matching analysis of 3358 SSRI users with 6716 non‐users, SSRI was associated with a higher risk of UGIB compared to non‐users (HR 1.95, 95% CI 1.41‐2.70). This result was consistent in sensitivity analysis with 1:1 PS matching (HR 2.13, 95% CI 1.50‐3.02) and multivariable analysis with 1‐month intervals (HR 1.81, 95% CI 1.34‐2.45) or 3‐month intervals (HR 1.61, 95% CI 1.20‐2.17). After stratifying by age, the increased risk of SSRI was only significant among patients >50 years.ConclusionSSRI users have a higher risk of hospitalisation for nonvariceal UGIB after treatment for HP, particularly among older patients.
Differential associations between impaired autobiographical memory recall and future thinking in people with and without schizophrenia
Authors: Barry Tom J. , Hallford David J. , Del Rey Francisco , Ricarte Jorge J. 
Published: October 2019

ObjectivesThe ability to think about future events serves a range of important functions. People with schizophrenia show impairments in future thinking. However, whether these impairments are specific to positive or negative events and to what extent they are associated with impairments in verbal fluency and autobiographical memory remains poorly understood.MethodsPeople with schizophrenia (n = 93) and people without psychiatric diagnoses (n = 111) were asked to generate future events and retrieve past autobiographical events and they also completed a test of verbal fluency. Participants also completed questionnaire measures of the positive and negative dimensions of schizophrenia and depression symptoms.ResultsPeople with schizophrenia generated significantly fewer positive and negative future events than controls. In a linear regression, the interaction between diagnosis and autobiographical memory retrieval explained a significant amount of variance in the number of future events that participants generated even when accounting for symptoms and verbal fluency. Past and future thinking abilities were correlated in controls but not in people with schizophrenia.ConclusionsPeople with schizophrenia may not rely on autobiographical content to imagine the future and may rely instead on semantic processes. Interventions that improve past and future thinking amongst people with schizophrenia are warranted.Practitioner points

Compared to control participants, people with schizophrenia have marked difficulty generating possible, positive and negative, future events.

Unlike controls, for people with schizophrenia there is no relation between their ability to remember past events and their ability to think about the future.

People with schizophrenia may have difficulty using their memories for their past to imagine and simulate possible future events.
Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor κB pathways
Authors: Muraoka Hiromi , Yoshimura Chihoko , Kawabata Rumi , Tsuji Shingo , Hashimoto Akihiro , Ochiiwa Hiroaki , Nakagawa Fumio , Fujioka Yayoi , Matsuo Kenichi , Ohkubo Shuichi 
Published: October 2019

AbstractThe ubiquitin proteasome pathway is essential for the proliferation and survival of multiple myeloma (MM) cells. TAS4464, a novel highly potent inhibitor of NEDD8 activating enzyme, selectively inactivates cullin‐RING ubiquitin E3 ligases, resulting in accumulation of their substrates. Here, we examined 14 MM cell lines treated with TAS4464. TAS4464 induced growth arrest and cell death in the MM cell lines even in the presence of bone marrow stromal cells. It also induced the accumulation of phospho‐inhibitor of κBα and phospho‐p100, impaired the activities of nuclear factor κB (NF‐κB) transcription factors p65 and RelB, and decreased the expression of NF‐κB target genes, suggesting that TAS4464 inhibits both the canonical and non–canonical NF‐κB pathways. TAS4464 had similar effects in an in vivo human‐MM xenograft mouse model in which it was also observed to have strong antitumor effects. TAS4464 synergistically enhanced the antitumor activities of the standard MM chemotherapies bortezomib, lenalidomide/dexamethasone, daratumumab and elotuzumab. Together, these results suggest that the anti–MM activity of TAS4464 occurs via inhibition of the NF‐κB pathways, and that treatment with TAS4464 is a potential approach for treating MM by single and combination therapies.
Industrial relations and adjustments to the crisis: A comparative micro‐statistical analysis of France and Great Britain
Authors: AMOSSÉ Thomas , ASKENAZY Philippe , CHEVALIER Martin , ERHEL Christine , PETIT Héloïse , REBÉRIOUX Antoine 
Published: October 2019

AbstractIn this comparative study, the authors analyse the relationships between industrial relations and workforce or wage adjustments in response to the 2007–08 crisis, using two highly comparable establishment‐level surveys conducted in Great Britain (WERS) and France (REPONSE) in 2010–12. Notwithstanding contextual differences in the countries’ productive systems and the timing and impact of the crisis, the relationships between industrial relations and adjustment strategies appear to have been similar (trade union presence not preventing adjustments). Differences in industrial relations are therefore not found to provide an explanation for the different modes of adjustment observed at the macroeconomic level.
Imagination, Hope and the Migrant Journey: Iraqi Asylum Seekers Looking for a Future in Europe
Authors: Koikkalainen Saara , Kyle David , Nykänen Tapio 
Published: October 2019

AbstractEurope received an unprecedented number of asylum seekers in 2015. This article examines Iraqi asylum seekers who journeyed through Europe in search of an idealized version of Finland, which they had imagined based on word‐of‐mouth and social media information. Through cognitive migration, the act of pre‐experiencing futures in different locations, Finland was seen to offer both subjective hope of personal growth and advancement and objective hope of safety and physical security. This hope motivated them to embark on a journey of 6,000 kilometers to the European North. Based on interview data and relevant studies, the article concludes that hope of a better, imagined future abroad acts as a powerful magnet for persons with poor prospects in their countries of origin. Hope is a kind of critical emotion strongly shaped by beliefs and real‐time opportunities; and as such, beliefs are notoriously difficult to change. Imagination, therefore, should not be overlooked when planning and implementing migration policies.
Subnational Migration States and the New Politics of Immigration
Authors: Paquet Mireille 
Published: October 2019

AbstractUsing Catherine Dauvergne's The New Politics of Immigration and the End of Settler Society (2016) as a starting point, this article explores subnational policy dynamics in Canada, Australia and the United States. It considers whether the trends associated with legalization, two‐step programmes, rapid policy changes and economic discourses are present in Canadian provinces as well as in U.S. and Australian states. It shows that the forces described by Dauvergne contribute to a further rescaling of policymaking and to the emergence of subnational migration states. However, this article also demonstrates that this common movement varies in its consequences and identifies two central subnational policy responses typical of the new politics of immigration: 1) the “economic subnational migration state” (Canada and Australia) and 2) the “access subnational migration state” (United States). The models and the global trends described in this article have implications for immigration policymaking in federations.
Clinical and genetic analysis in a family with familial renal glucosuria: Identification of an N101K mutation in the sodium–glucose cotransporter 2 encoded by a solute carrier family 5 member 2 gene
Authors: Sada Kentaro , Hidaka Shuji , Imaishi Nao , Shibata Kohei , Katashima Rumi , Noso Shinsuke , Ikegami Hiroshi , Kakuma Tetsuya , Shibata Hirotaka 
Published: October 2019

AbstractWe report the identification of a mutation in the solute carrier family 5 member 2 (SLC5A2) gene, which encodes sodium–glucose cotransporter 2, in a family with familial renal glucosuria. The proband was a 26‐year‐old Japanese man referred to the diabetes division with repeated glucosuria without hyperglycemia. His mother, uncle and grandfather also had a history of glucosuria. A heterozygous missense mutation (c.303T>A:p.N101K) in SLC5A2 was identified in the patient and his mother, but not in 200 chromosomes from 100 healthy and unrelated individuals, or in 3,408 Japanese individuals in the Tohoku Medical Megabank. Furthermore, bioinformatics software predicted that this lesion would be pathogenic. We infer that the mutation led to clinically relevant sodium–glucose cotransporter 2 dysfunction. The patient showed no symptoms of hypoglycemia, but continuous glucose monitoring confirmed asymptomatic hypoglycemia.
Using a repositioning splint to determine reproducibility in the color registers of a dental spectrophotometer
Authors: Fernández Millán David , Gallas Torreira Mercedes , Alonso de la Peña Víctor 
Published: October 2019

AbstractObjectivesThe purpose of this study was to assess if the use of intraoral positioning guides could increase the reproducibility of color measurements with a dental spectrophotometer.MethodsTwenty‐three subjects were selected, and positioning guides for the maxillary arch of each participant were fabricated with clear 4 mm thermo‐sheets. One orifice was made in the center of the clinical crown of the upper‐right central incisor and another in the canine, with an external 6 mm diameter trephine. Color measurements were performed with a Vita EasyShade Compact IV dental spectrophotometer by the same operator in the same conditions. Forty measurements were taken per patient, 20 for each tooth, 10 with a positioning guide, and 10 without one. Before each measurement, the spectrophotometer was calibrated following the manufacturer's instructions.ResultsUsing the Wilcoxon test to evaluate nonparametric variables, there are statistically significant differences (P < .05) between the use or not of positioner for color recording with spectrophotometer. Greater repeatability of the measurements is obtained using repositioning split.ConclusionsWithin the limitations of this study, the use of positioning guides provides greater reproducibility in spectrophotometer measurements for all parameters of tooth 11 and for some parameters of tooth 13.Clinical significanceThe use of a positioning guide for color measurement with a dental spectrophotometer allows a greater reproducibility of the measurements to be obtained. Achieving repeatable measurements is essential for studying the same area of the tooth, for example, in bleaching treatments and in color checks for prosthetic treatments.
A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes
Authors: Khmaladze Ia , Österlund Christina , Smiljanic Sandra , Hrapovic Nina , Lafon‐Kolb Virginie , Amini Nahid , Xi Li , Fabre Susanne 
Published: October 2019

AbstractBackgroundHigh demand on anti‐aging skin care encourage the improvement and development of more personalized formulations with additional benefits for general skin health and age associated skin signs. The skin aging physical and biological phenotypes manifest differently between diverse ethnic populations. A highly polluted environment can be viewed as an extrinsic factor accelerating the skin aging process.AimTo develop a unique formula with active complexes, having multifunctional effects for anti‐pollution, brightening and anti‐aging/barrier strengthening purposes with confirmed activities in vitro and ex vivo skin models, suitable for polluted skin.MethodsIn vitro culture model with primary human skin cells, ex vivo studies with full‐thickness human skin, melanocyte 3D coculture model, gene expression of epidermal and dermal genes, anti‐glycation, proteasomal activity, melanin, and cytokine assays.ResultsIn vitro and ex vivo studies clearly demonstrated that diglucosyl gallic acid (active A) and the formulation complex inhibited pollution mediated MMP1 protein, CYP1A1 gene expression, and IL‐6 protein secretion, while caprylic/capric triglyceride, diacetyl boldine (active B) had anti‐melanogenic effect in in vitro primary melanocyte monoculture and 3D spheroid model. Another active compound, acetyl dipeptide 1 cetyl ester (active D), significantly upregulated epidermal barrier genes (Aquaporin 3 [AQP3], Filaggrin [FLG], caspase 14, and keratin 10) in human primary keratinocytes. Interestingly, both acetyl dipeptide 1 cetyl ester (active D) and niacinamide (active C) improved dermal gene expression (fibrillin‐1, Collagen type 1 alpha 1, Decorin, Lysyl oxidase‐like 1) and, moreover, had significant anti‐glycant and proteasomal promoter activity in human primary fibroblasts.ConclusionConsidering consumers need in heavily polluted areas, we developed a multipurpose formulation comprised of unique active complexes toward pollution, pollution induced inflammation, skin brightening, and antiaging concerns with beneficial results demonstrated by in vitro and ex vivo studies.
Imagination, Self‐Knowledge, and Poise: Jim March’s Lessons for Leadership
Authors: Patriotta Gerardo 
Published: October 2019

AbstractJames G. March was a founding father of modern organization theory, and arguably its most eclectic scholar. His elegant writings, which were underpinned by a behavioural view of organizations, spanned ambiguity and choice, rationality and decision‐making, organizational change, organizational learning, and institutional theory, among others. In this editorial, we remember Jim March by reflecting on his lessons for leadership. It is structured into three parts, each portraying a key aspect of contemporary leadership: imagination, self‐knowledge, and poise. March believed that these qualities were essential to leadership, and he embodied them to the fullest.
What would you do? A new approach to health competence based on situational judgment
Authors: Robinson Michael D. , Persich Michelle R. , Krishnakumar Sukumarakurup 
Published: October 2019

AbstractObjectiveAn advantage of the trait approach to health is that it implicates common elements to multiple different health behaviors. An advantage of the social‐cognitive approach, in contrast, is that it models the situational factors that are likely to elicit particular behavioral reactions. The present research sought to combine the advantages of these two approaches.MethodA situational judgment method was developed to quantify general variations in health competence (HC) in terms of more specific responses to simulated health‐challenging events.ResultsAfter developing the method, Study 1 showed that individual differences in HC were systematically related to approach‐related coping tendencies and behaviors known to be health promoting. Study 2 then showed that variations in HC predicted both health behaviors and quality of life among older individuals.ConclusionsThe results highlight a new form of HC that is not dependent on self‐reports of ability.
Ethanol thresholds in water and beer
Authors: Guttman Gretchen A. , Soldavini Ashley M. , Simons Christopher T. 
Published: October 2019

AbstractLittle information exists regarding ethanol thresholds or how thresholds change depending upon the matrix of evaluation. The objective of this experiment was to determine the detection threshold of ethanol in water and the just‐noticeable difference (JND) thresholds for ethanol in water and beer. We also sought to determine whether ethanol thresholds correlate with frequency of ethanol consumption. The best estimate of threshold (BET) was determined for 75 subjects in water and/or beer using the ascending method of limits. In water, the group detection BET was 0.66 ± 0.08% with no significant difference between males and females. In water and beer containing 5% ethanol, the group JND BETs were 7.9 ± 1.1% and 11.0 ± 1.1%, respectively. The significant increase of ethanol thresholds in beer compared to water likely reflects the impact of the matrix on the sensory properties evoked by ethanol. No significant differences between males and females were found for ethanol JND thresholds in water, however, in beer, JND thresholds were significantly lower for males compared to females. Ethanol JND thresholds obtained in water and beer were not associated with self‐reported frequency of alcohol consumption.Practical ApplicationsThe present study provides relevant details regarding the levels of ethanol that can be discriminated in water and beer. The sensory qualities of ethanol have been proposed to be the most consistent and relevant stimuli to immediately predict alcohol's postabsorptive effects. This implies that humans can accurately detect and discriminate between varying levels of ethanol. However, the present results suggest that the presence of other flavor compounds in a complex matrix such as beer makes discriminating ethanol levels difficult.
A possible solution to model nonlinearity in elimination and distributional clearances with α2‐adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses
Authors: Gozalo‐Marcilla Miguel , Moreira da Silva Rodrigo , Pacca Loureiro Luna Stelio , Rodrigues de Oliveira Alice , Werneck Fonseca Mariana , Peporine Lopes Norberto , Taylor Polly M. , Pelligand Ludovic 
Published: October 2019

AbstractThe alpha(α)2‐agonist detomidine is used for equine sedation with opioids such as methadone. We retrieved the data from two randomized, crossover studies where detomidine and methadone were given intravenously alone or combined asboli(STUDY 1) (Gozalo‐Marcilla et al., 2017,Veterinary Anaesthesia and Analgesia, 2017,44, 1116) or as 2‐hr constant rate infusions (STUDY 2) (Gozalo‐Marcilla et al., 2019,Equine Veterinary Journal,51, 530). Plasma drug concentrations were measured with a validated tandem Mass Spectrometry assay. We used nonlinear mixed effect modelling and took pharmacokinetic (PK) data from both studies to fit simultaneously both drugs and explore their nonlinear kinetics. Two significant improvements over the classical mammillary two‐compartment model were identified. First, the inclusion of an effect of detomidine plasma concentration on the elimination clearances (Cls) of both drugs improved the fit of detomidine (Objective Function Value [OFV]: −160) and methadone (OFV: −132) submodels. Second, a detomidine concentration‐dependent reduction of distributional Cls of each drug further improved detomidine (OFV: −60) and methadone (OFV: −52) submodel fits. Using the PK data from both studies (a) helped exploring hypotheses on the nonlinearity of the elimination and distributional Cls and (b) allowed inclusion of dynamic effects of detomidine plasma concentration in the model which are compatible with the pharmacology of detomidine (vasoconstriction and reduction in cardiac output).
The case for “structural missingness:” A critical discourse of missed care
Authors: Hopkins Walsh Jane , Dillard‐Wright Jessica 
Published: October 2019

AbstractStimulated by our conversations at the 2018 International Philosophy of Nursing Society Conference and our shared interests, the coauthors present an argument for augmenting the broader discussion of “missed care” with our synthesized concept called structural missingness. We take the problem of missed care to be largely grounded on a particular economic construction of the healthcare system within an era of what some are calling the Capitalocene, capturing the pervasive influence of capitalism on nature, humanity and the world order. Our perspective is that of the United States, however, extrapolations can be made to the social and healthcare systems in other countries. We are concerned with the underlying conditions that structurally reify inequality and ultimately undermine nursing practice. To situate the discussion, we briefly review existing literature on the contextualization of missed care. We understand contemporary circumstances of missed care as a function of the neoliberalization of healthcare, including the idea of nursing as a commodity. From this, we discuss the implications of missed care, which forms the basis of our critique. Synthesizing the term “structural missingness, we locate a moral imperative in the professional and disciplinary commitments of nursing to consider who and what have been left out. This moral imperative for the nursing profession, along with other social and health related professions, underscores our obligation to be involved in uncovering inequities and conceptualizing upstream solutions for structural missingness.
Preliminary exploration of the potential of spliceosome‐associated protein 130 for predicting disease severity in Crohn's disease
Authors: Gong Wenbin , Guo Kun , Zheng Tao , Fang Miao , Xie Haohao , Li Weijie , Hong Zhiwu , Ren Huajian , Gu Guosheng , Wang Gefei , Wang Zhiming , Wu Xiuwen , Ren Jianan 
Published: October 2019

AbstractThe role of spliceosome‐associated protein 130 (SAP130) in gut inflammation, particularly in Crohn's disease (CD), remains unclear. The aim of our study was to analyze correlations between serum SAP130 levels and CD severity, and to assess its predictive value for the clinical efficacy of exclusive enteral nutrition (EEN) in CD. Correlations between the SAP130 levels and CD severity were evaluated. SAP130 and its receptor Mincle (macrophage‐inducible C‐type lectin) in the colon tissue in active CD were measured. Furthermore, the serum SAP130 level was investigated as a predictor of clinical efficacy in patients treated with EEN. The serum SAP130 levels significantly increased in patients with active CD compared with patients in remission for CD (P < 0.001) and control individuals (P < 0.001), and they varied according to clinical activity and significantly correlated with disease severity. In parallel, the expression of both SAP130 and Mincle in colon tissue was elevated in active CD. Additionally, the serum SAP130 level declined in patients with active CD who achieved efficacy at week 8 after EEN therapy. This preliminary evidence shows that SAP130 might be a potential noninvasive biomarker that correlates well with CD severity and the clinical efficacy of EEN in CD.