bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectives on Treatment of Metastatic Colorectal Cancer with Immune Checkpoint Inhibitor Therapy
Authors: Morse Michael A. , Hochster Howard , Benson Al 
Published: August 2019

Abstract

Despite lengthening survival, death rates from metastatic colorectal cancer (CRC) remain unacceptably high, with a bright spot being the demonstration of durable responses in patients with CRC who have mismatch repair-deficient (dMMR) and/or microsatellite instability-high (MSI-H) tumors and are treated with immune checkpoint inhibitor therapy. Nivolumab and pembrolizumab, as well as nivolumab in combination with low-dose ipilimumab—all checkpoint inhibitors—are currently approved by the U.S. Food and Drug Administration (FDA) for patients with MSI-H/dMMR metastatic CRC that progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan. Nonetheless, there are a number of questions and considerations in the use of these checkpoint inhibitor therapies. Using a question-and-answer format, this review summarizes the scientific rationale for immune checkpoint inhibitor therapy in CRC, including the effects of tumor factors such as genetic aberrations and mutational load on the immune response, particularly in patients with MSI-H/dMMR disease. We discuss response patterns, response criteria, and immune-related adverse events using findings from published efficacy and safety data of immune checkpoint inhibitor therapy in metastatic CRC. We also discuss issues surrounding treatment sequencing, incorporating approved checkpoint inhibitors into the current treatment paradigm, and the multiple investigational strategies that may optimize immunotherapy for advanced CRC in the future, including novel combination therapies.
Effect of near-field earthquake on isolated bridge considering soil–structure interaction
Authors: Naghibi Amireddin , Javadi Pasha , Zarfam Panam 
Published: August 2019

In the 1995 Kobe earthquake, different bearing fractures were observed in isolated bridges. Piers and bearings were the first and second vulnerable structural elements. The estimation load due to far-field earthquakes can be calculated using BS EN 1998-1:2004, but research on this issue for near-field earthquakes is limited. The aim of this study was to verify the effect of the vertical component of near-field earthquakes on structural responses and compare the results with values suggested using BS EN 1998-1:2004. An isolated bridge was designed based on Eurocode standards and modelled in OpenSees. Moreover, since soil–structure interaction (SSI) has an inherent effect on bridge structures, the induced vertical accelerations were compared with and without SSI effects. It was found that vertical acceleration decreased in the model including SSI effects. The shear strain of the elastomers was found to be within the range allowed by BS EN 1998-2:2005.
Un acercamiento sintagmático al concepto de liderazgo
Authors: Hurtado Jackeline 
Published: August 2019

Este trabajo se centra en un conjunto de reflexiones acerca de las teorías de liderazgo, con el objetivo de desarrollar una visión integradora del mismo, a partir de un proceso sintagmático. Los criterios de base se ubican en la comprensión holística. Se parte de una concepción integral del ser humano, y se aplican algunos principios de la holística que son considerados en el pensamiento complejo. Se aplicó la sintagmagrafía como método, el primer paso fue realizar un proceso de revisión documental de los planteamientos y conceptos aportados por diversos autores y teorías de liderazgo, para describir cada postura El segundo paso fue comparar las teorías y conceptos para precisar el núcleo sintagmático (lo que todos tenían en común), el tercer paso fue detectar los aspectos paradigmáticos (lo exclusivo de cada punto de vista), por último, como resultado, se identificaron algunos rasgos de complementariedad y se esbozaron las características del liderazgo con base en la integralidad. Además se introdujeron algunos conceptos originales relacionados con las sinergias del liderazgo, como atracción, tracción, centrífuga y tensión, y algunas ideas para desarrollos posteriores acerca del liderazgo visto desde el ser en situación, el ser en relación y el ser en devenir.
Ácido ursólico pode ser eficaz na redução da adiposidade e aumento da massa muscular? Uma revisão
Authors: Barreto Lobo Patrícia Cristina , Pimentel Gustavo Duarte , Mota João Felipe 
Published: August 2019

Objetivo: Revisar estudos que avaliaram o uso do AU em seres humanos e seus efeitos na adiposidade e massa muscular. Métodos: A busca dos artigos foi realizada na base de dados PubMed. Foram excluídos estudos irrelevantes ao tema e experimentos com animais, sendo incluídos na revisão quatro trabalhos. Resultados e Discussão: Os estudos apontam que o AU está associado com redução da gordura corporal (via termogênese) e controle glicêmico, e que, associado ao exercício resistido pode aumentar a síntese proteica (via a sinalização da mTOR). Conclusão: São necessários mais estudos clínicos para esclarecer a dose terapêutica, o público alvo e o efeito na perda de gordura corporal e/ou ganho de massa muscular.
Salvia verticillata L. (Dadırak)’nın Tohum Dormansisinin Kırılmasında Farklı Uygulamaların Etkileri
Authors: TURSUN Ayşe Özlem 
Published: August 2019

Lamiaceae familyası
içerisinde en büyük cins olan Salvia
türleri dünyada geniş bir alana yayılmış olup 900 kadar adaçayı türü
bulunmaktadır. Salvia cinsine ait tohumlarda dormansi söz konusudur ve tohum
kabuğundaki müsilaj maddesi çimlenmeyi engelleyici önemli bir faktördür. Bu
çalışma, Salvia verticillata’nın
tohumlarındaki dormansinin kırılması üzerine farklı uygulamaların etkisini
belirlemek amacıyla tesadüf parselleri deneme desenine göre 4 tekerrürlü olarak
kurulmuştur. Çalışmada denemeler 14 saat 26 0C ve 10 saat 16 0C
olarak tamamen aydınlık, karanlık ve 14 saat aydınlık ve 10 saat karanlık
olacak şekilde kurulmuştur. Çalışma sonucunda en yüksek
tohum çimlenmesi %74 ile 2000 ppm giberellik asitin (GA3) 26/16 0C
tamamen karanlık uygulamasından elde edilmiştir. S. verticillata tohumları %96’lık etanolde 30 dakika tutulduktan
sonra 14 saat aydınlık ve 10 saat karanlık ortam, %96’lık etanolde 120 dakika
tutulduktan sonra aydınlık, karanlık ve 14 saat aydınlık ve 10 saat karanlık
ortam, hidroklorik asitte 60 dakika tutulduktan sonra 14 saat aydınlık ve 10 saat karanlık
uygulamaları ile %15'lik sodyum hipokloritte 10 dakika tutulduktan sonra
aydınlık uygulamasında çimlenme olmamıştır. Bu sonuçlar ışığında giberellik asit
uygulamalarının adaçayı tohumlarındaki dormansinin kırılmasında etkili olup
çimlenme oranını arttırdığı ve yeni fide elde etmede önemli olacağı
anlaşılmıştır.
Stunting: a multisector challenges and unfinished nutrition agenda
Authors: Karyadi Elvina 
Published: August 2019

It was a great news that during the President election campaign, both President and Vice President candidates addressed a stunting problem during the debate. It shows that stunting is placed as national priority of nutrition problems. Stunting is part of a wider nutrition crises in Indonesia: wasting, anemia and double-burden of malnutrition. According to the 2018 National Health Survey (RISKESDAS), 30.8 percent of Indonesian children under 5 years of age were stunted (almost 8 million children), 17.7 percent were underweight, 10.2 percent were wasted (low weight-for-height). Although the prevalence of stunting declined significantly from the 2013 (37.2%), the stunting rates remain unacceptably high. A child that is wasted faces double the risk of mortality associated with stunting. Even, a child that is both stunted and wasted faces a higher risk. Frequent episodes of wasting increase the risk of stunting.
The impact of therapy on the quality of life in asymptomatic patients with freshly detected hypertension
Authors: Mishra Satish Chandra , Singh Vishal , Prakash Sudeep , Pandey Pushkar 
Published: August 2019

Background: Hypertension is an commonly encountered disease which adversely affect all aspects of quality of life (QoL). The existing studies are confounded by the presence of multiple comorbidities and inclusion of elderly, which by themselves impairs the QoL. There is thus a need to study the impact of hypertension on QoL, in isolation.Method: This is a single center, prospective, intention to treat, observation study. The aim of the study is to evaluate the change in the QoL over six months, in newly diagnosed asymptomatic patients of hypertension. The tools used to assess the QoL included World Health Organisation’s Quality of Life Questionnaire (WHOQOL- BREF) and Short Form-36 (SF-36).Result: A total of 232 patients (172 males and 60 females) were enrolled in the study. The mean age was 44.66 years. A total of 102 patients (43.97%) had stage-1 and 130 patients (56.03%) had stage-2 hypertension. The female gender is associated with a higher likelihood of presentation with stage-2 hypertension. The male cohort had a better baseline QoL. The desired blood pressures was achieved in 40.52%. With therapy, the QoL improved significantly; sub-hoc analysis showed, the improvement was higher in males and those with stage-1 hypertension. There is an inverse relationship between the QoL and requirement for higher number of antihypertensive mediations.Conclusions: In patients with asymptomatic primary hypertension, treatment improves all aspects of QoL. The factors adversely affecting the QoL include female gender, higher stage of hypertension, poor blood pressure control and requirement of higher numbers of antihypertensive medicine.
O LIVRO DIDÁTICO E AS SOCIEDADES INDÍGENAS
Authors: Silva Vitor Ferreira 
Published: August 2019

O presente trabalho busca perceber as representações acerca da temática indígena a partir do livro didático de História. Nosso objetivo é entender qual é o tipo de conhecimento que a escola reproduz sobre os indígenas e, a partir disso, pontuar os elementos que colaboram para
uma visão típica sobre os nativos. Dentro de uma breve discussão sobre o currículo de história, livro didático e representações sobre os indígenas, veremos como a invisibilidade do “índio” é reforçada por uma narrativa tradicional e ainda hegemônica nos livros escolares.
El problema de marco y la aptitud de las emociones para resolver la dificultad de la regresión
Authors: Silenzi María Inés 
Published: August 2019

El problema de marco, el cual que cuestiona el modo en que los seres humanos determinamos relevancia eficientemente, ha sido considerado por algunos filósofos como un obstáculo para el progreso de las Ciencias Cognitivas (Dreyfus, 2007). En este trabajo, cuestionamos tal pesimismo estimando la aptitud de las emociones para resolver una de sus principales dificultades, a saber, la dificultad de la regresión. Luego de dilucidar la dificultad mencionada, propondremos dos grandes posiciones frente a su resolución: aquella que considera el éxito epistémico de las emociones al resolverla (Elgin, 1996; Hookway 2003 y de Sousa, 1980) y aquella que, más prudentemente, estima sus limitaciones (Wild y Dohrn, 2008). Sostendremos que si bien la función de saliencia-relevancia de las emociones parece ofrecer una solución a la dificultad de la regresión, y con ello al aspecto epistemológico del problema de marco, esto en realidad no es así, puesto que lejos de resolver tal dificultad, la desplazan hacia otros problemas pendientes de solución.
Importancia del lenguaje y método filosófico en el segundo Wittgenstein
Authors: Bentolila Héctor Rodolfo 
Published: August 2019

El articulo responde a la pregunta ¿Por qué importa el lenguaje en filosofía?, formulada hace más de cuarenta años por el filósofo canadiense, Ian Hacking. Al hacerlo, parte de la nueva concepción del método filosófico desarrollada por Wittgenstein en sus Investigaciones Filosóficas. El objetivo es mostrar que el lenguaje importa a la filosofía, sobre todo, como el medio natural en que los seres humanos actúan y se mueven habitualmente. De dicha condición, y de comparar los usos filosóficos del lenguaje con las acciones lingüísticas primitivas -de donde derivan aquellos- se desprende un estilo de actuar que disuelve los pseudoproblemas de la filosofía tradicional.
El artículo responde a la pregunta ¿Por qué importa el lenguaje en filosofía?, formulada hace más de cuarenta años por el filósofo canadiense, Ian Hacking. Al hacerlo, parte de la nueva concepción del método filosófico desarrollada por Wittgenstein en sus Investigaciones Filosóficas. El objetivo es mostrar que el lenguaje importa a la filosofía, sobre todo, como el medio natural en que los seres humanos actúan y se mueven habitualmente. De dicha condición, y de comparar los usos filosóficos del lenguaje con las acciones lingüísticasprimitivas -de donde derivan aquellos- se desprende un estilo de actuar que disuelve los pseudoproblemas de la filosofía tradicional
Framework For Lossless Data Compression Using Python
Authors: Malik Manas 
Published: August 2019

A lot has been done in the field of data compression, yet we don’t have a proper application for compressing daily usage files. There are appropriate and very specific tools online that provide files to be compressed and saved, but the content we use for streaming our videos, be it a Netflix video or a gaming theater play, data consumed is beyond the calculation of a user. Back-end developers know all about it and as developers we have acknowledged it but not yet achieved it in providing on an ease level. Since the user would not never be concerned about compression, developers can always take initiative while building the application to provide accessibility with compression before-hand. We have decided to create a framework that will provide all the functionality needed for a developer to add this feature. Making use of the python language this process can work. I’m a big fan of Python, mostly because it has a vibrant developer community that has helped produce an unparalleled collection of libraries that enable one to add features to applications quickly. For the DEFLATE lossless compression, has a higher level of abstraction provided by the zlib C library, in Python it is generally provided by the Python zlib library which is an interface, we have a lot to do including the audio, video and subtitles of the file. We also make use of the fabulous ffmpy library. ffmpy is a Python library that provides access to the ffmpeg command line utility. ffmpeg is a command-line application that can perform several different kinds of transformations on video files, including video compression, which is the most commonly requested feature of ffmpeg. Frame rate and audio synchronization are few other parameters to look closely. This is an ongoing project and there remains few implementation aspects, data compression remains a concern when touched upon the design. We along with python community intend to solve this issue.
Evaluating Passwords User Behavior and the Psychology of Password Management
Authors: Alothman Walid Ali Sulaiman Ali 
Published: August 2019

Regardless of how complex an association's security framework is, it stays helpless because of the human factor. Content based passwords are usually utilized for verification in figuring condition. Despite the fact that passwords are considered as the underlying line of assurance for users, they stay simple to compromise. To improve the security of frameworks, different password synthesis policies are embraced. These strategies guarantee that users are made to pick solid passwords that assistance anticipate online ruptures and information spills. Be that as it may, it likewise make passwords hard to retain and review, diminishing the general ease of use. In this examination we researched the ease of use of password strategies and users' view of password security. We additionally reviewed and examined the patterns practiced by users while producing passwords (Crantor, Hong and Reiter, 2016).
Users are not as mindful of security prerequisites and practices as they think. By far most of users' passwords are breakable within days or shorter. Strikingly, we found that the utilization of numbers and uppercase letters is common among clients. Numbers are generally utilized toward the end of the passwords and uppercase letters are for the most part utilized toward the start of passwords. The presence of such patterns makes it simpler for attackers to create progressively compelling dictionaries. In light of the examination in this investigation, we make suggestions to the IT office to improve the password policy (Shen, 2016).
A Comparison between the Empirical and Mechanistic-Empirical Pavement Design Methods
Authors: Shallal Dr. Mohammed , Ahmed Elsir Suliman 
Published: August 2019

In this paper a comparative study has been carried out between the Mechanistic-Empirical Pavement Design Methods and the Empirical Pavement Design Methods. For the purpose of this paper, nine pavement design sections have been prepared using the Mechanistic-Empirical Methods represented by the Asphalt Institute Design Method (SW-1 software of the Asphalt Institute) and the Empirical Design represented by AASHTO 1993 and TRL Road Note No.31, using the same traffic loading and subgrade strength. Three traffic loading scenarios have been considered for this study.
(Key words: Mechanistic-Empirical, Empirical, axle loads, Subgrade Strength, pavement design)
Evaluation of Adoption of Interlocking Soil Technology in Development of Adequate and Sustainable Housing Projects in Nandi County, Kenya.
Authors: Euginia Chang’ach , Omboto Prof. Peter , Mulongo Prof. Leonard 
Published: August 2019

Project success incorporates both project management success and product success. The basic criteria for evaluating project success are scope, time, cost, and client satisfaction with the final product or service. The use of interlocking stabilized soil block technology in housing projects has been promoted in Kenya as a means to address poverty, sustainable housing and housing affordability challenges facing many Kenyans. The programme was conceptualized, planned and implemented across the country. The uptake of the technology has however been slow. This study sought to evaluate the adoption of the interlocking soil technology in development of adequate and sustainable housing projects in Nandi County. The variables analyzed for this study were; understanding of the processes of production, community participation, benefits of the technology and the challenges of cost and information dissemination. The study was guided by the Innovation Diffusion and Systems theories. The study adopted a descriptive survey design. 155 households were sampled out of the 81,672 households in the target population. Quantitative data was collected using questionnaires. Data was analyzed using descriptive and inferential statistics. The study established that the interlocking technology is not widely practiced. There is an average understanding of the processes of production, community participation is not widely embraced, information dissemination is not effective and efficient and the costs were not affordable. The study recommends that action should be taken to promote better understanding of the processes of production, enhance community participation and addressing the challenges of cost and information dissemination.
MEDIA SOSIAL SEBAGAI SARANA EKSISTENSI DIRI (Reception Analysis Mahasiswa Fakultas Ilmu Komunikasi Universitas Mercu Buana Angkatan 2016)
Authors: Basarah Finy F 
Published: August 2019

The existence of social media made it easier for anyone to publish any activities in any social medias they had.
This activity seemed to indicate the desire to be acknowledged by others for the existence of people who actively published each activity.
Using the theory of Encoding-Decoding from Stuart Hall, Existentialist Theory of Jean Paul Sartre, and the method of Reception Analysis, 8 (eight) Faculty of Communication Mercu Buana Universityâ€™s students, class of 2016, gave a view how they produced the meaning of each social media content produced by themselves.
The result of this research was not everyone who actively used social media to publish was an existentialist. 1 (one) out of 8 (eight) informants in this study did not belong to any modes in which Sartre is located, 3 (three) informants belonged to the two modes, 2 (two) people belonged to Being-in-itself, 1 (one) person belonged to Being-for-itself, and 1 (one) person belonged to Being-for-others.

Keywords:Social Media, Existence, Existentialist, Encoding-Decoding, Reception Analysis

Abstrak
Keberadaan media sosial memudahkan siapapun untuk mempublikasikan setiap kegiatan di sejumlah media sosial yang dimilikinya. Kegiatan ini seolah menunjukkan adanya keinginan untuk diakui oleh orang lain akan eksistensi orang yang aktif mempublikasikan setiap kegiatannya tersebut. Dengan mempergunakan teori Encoding-Decoding dari Stuart Hall, Teori Eksistensialis dari Jean Paul Sartre, dan metode Reception Analysis, terpilih 8 (delapan) orang mahasiswa Fikom Universitas Mercu Buana angkatan 2016 yang telah memberikan pandangan bagaimana mereka memproduksi makna dari setiap konten media sosial yang diproduksi sendiri. Hasil penelitian yaitu tidak semua orang yang aktif menggunakan media sosial untuk mempublikasikannya adalah seorang eksistentialis. 1 (satu) dari 8 (delapan) informan dalam penelitian ini tidak termasuk ke dalam modus cara berada Sartre manapun, 3 (tiga) orang informan termasuk ke dua modus cara berada, 2 (dua) orang termasuk ke dalam modus cara berada Being-in-itself, 1 (satu) orang termasuk ke dalam modus cara berada Being-for-itself, dan 1 (satu) orang termasuk ke dalam modus cara berada Being-for-others.

Kata Kunci: Media Sosial, Eksistensi, Eksistensialis, Encoding-Decoding, Reception Analysis.
KUALITAS KE PROFESSIONAL-AN PROFESI BIDANG KOMUNIKASI (Study Deskriptif Tanggapan User Terhadap Alumni Program Studi D3 Humas Universitas Negeri Jakarta)
Authors: Sari Wina Puspita , Sugiarto Asep 
Published: August 2019

Asean Economic Community (AEC) impacts the area of employment become more competitive. Indonesia has to improve human resources through education. University has to create professional workers to compete with other ASEAN country labors. Prodi DIII Public Relations in Universitas Negeri Jakarta have graduated public relations diploma since 2007. They have worked in several communication industries as a public relations officer. We have to know how professional they are according evaluation of their managers.
Indicators of professional status include 1. spesialized educational preparation to acquire unique knowledge and skill. 2. A body of theory-based knowledge, developed through research, that provides us principles of appropriate public relations practice. 3. Code of ethic and standards of performance established and enforced by a self governing association of colleagues. 4. Autonomy in practice and acceptance of personal responsibility by practitioners. 5. Recognition by the community of a unique and essential service.
This research used qualitative perpective and descriptive method. Primery data are obtained by doing depth interview with key informan and informan.
The results are our alumni do several pr activities in qualification of public relations competence schema from Lembaga Sertifikasi Profesi Public Relations Indonesia. They are in different level spread from junior, middle, expert or managerial according their working period. Evaluation of their managers are good. Our alumni have ability to finish their duties. They have good mental attitude. They never break the rules or cod of conduct. But they still have to practice a lot and guidance.
The conclusions, the evaluation of alumni of UNJ DIII Public Relations are good. They are professional according their job descriptions but they still have to practice a lot. To increase the status, writer suggest to adjust our alumni with sertificate of competence from sertifications institutions of pr.
Key Word : AEC, professional status, public relation profession