bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse childhood experiences and adult mood problems: evidence from a five-decade prospective birth cohort
Authors: Selous Camilla , Kelly-Irving Michelle , Maughan Barbara , Eyre Olga , Rice Frances , Collishaw Stephan 
Published: October 2019

AbstractBackgroundRetrospectively recalled adverse childhood experiences (ACEs) are associated with adult mood problems, but evidence from prospective population cohorts is limited. The aims of this study were to test links between prospectively ascertained ACEs and adult mood problems up to age 50, to examine the role of child mental health in accounting for observed associations, and to test gender differences in associations.MethodsThe National Child Development Study is a UK population cohort of children born in 1958. ACEs were defined using parent or teacher reports of family adversity (parental separation, child taken into care, parental neglect, family mental health service use, alcoholism and criminality) at ages 7–16. Children with no known (n = 9168), single (n = 2488) and multiple (n = 897) ACEs were identified in childhood. Adult mood problems were assessed using the Malaise inventory at ages 23, 33, 42 and 50 years. Associations were examined separately for males and females.ResultsExperiencing single or multiple ACEs was associated with increased rates of adult mood problems after adjustment for childhood psychopathology and confounders at birth [2+ v. 0 ACEs – men: age 23: odds ratio (OR) 2.36 (95% confidence interval (CI) 1.7–3.3); age 33: OR 2.40 (1.7–3.4); age 42: OR 1.85 (1.4–2.4); age 50: OR 2.63 (2.0–3.5); women: age 23: OR 2.00 (95% CI 1.5–2.6); age 33: OR 1.81 (1.3–2.5); age 42: OR 1.59 (1.2–2.1); age 50: OR 1.32 (1.0–1.7)].ConclusionsChildren exposed to ACEs are at elevated risk for adult mood problems and a priority for early prevention irrespective of the presence of psychopathology in childhood.
A Belmont Report for Animals?
Authors: FERDOWSIAN HOPE , JOHNSON L. SYD M , JOHNSON JANE , FENTON ANDREW , SHRIVER ADAM , GLUCK JOHN 
Published: October 2019

Abstract:Human and animal research both operate within established standards. In the United States, criticism of the human research environment and recorded abuses of human research subjects served as the impetus for the establishment of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, and the resulting Belmont Report. The Belmont Report established key ethical principles to which human research should adhere: respect for autonomy, obligations to beneficence and justice, and special protections for vulnerable individuals and populations. While current guidelines appropriately aim to protect the individual interests of human participants in research, no similar, comprehensive, and principled effort has addressed the use of (nonhuman) animals in research. Although published policies regarding animal research provide relevant regulatory guidance, the lack of a fundamental effort to explore the ethical issues and principles that should guide decisions about the potential use of animals in research has led to unclear and disparate policies. Here, we explore how the ethical principles outlined in the Belmont Report could be applied consistently to animals. We describe how concepts such as respect for autonomy and obligations to beneficence and justice could be applied to animals, as well as how animals are entitled to special protections as a result of their vulnerability.
THE MODAL LOGIC OF SET-THEORETIC POTENTIALISM AND THE POTENTIALIST MAXIMALITY PRINCIPLES
Authors: HAMKINS JOEL DAVID , LINNEBO ØYSTEIN 
Published: October 2019

AbstractWe analyze the precise modal commitments of several natural varieties of set-theoretic potentialism, using tools we develop for a general model-theoretic account of potentialism, building on those of Hamkins, Leibman and Löwe [14], including the use of buttons, switches, dials and ratchets. Among the potentialist conceptions we consider are: rank potentialism (true in all larger
$V_\beta $
), Grothendieck–Zermelo potentialism (true in all larger
$V_\kappa $
for inaccessible cardinals
$\kappa $
), transitive-set potentialism (true in all larger transitive sets), forcing potentialism (true in all forcing extensions), countable-transitive-model potentialism (true in all larger countable transitive models of ZFC), countable-model potentialism (true in all larger countable models of ZFC), and others. In each case, we identify lower bounds for the modal validities, which are generally either S4.2 or S4.3, and an upper bound of S5, proving in each case that these bounds are optimal. The validity of S5 in a world is a potentialist maximality principle, an interesting set-theoretic principle of its own. The results can be viewed as providing an analysis of the modal commitments of the various set-theoretic multiverse conceptions corresponding to each potentialist account.
MATHEMATICAL RIGOR AND PROOF
Authors: HAMAMI YACIN 
Published: October 2019

AbstractMathematical proof is the primary form of justification for mathematical knowledge, but in order to count as a proper justification for a piece of mathematical knowledge, a mathematical proof must be rigorous. What does it mean then for a mathematical proof to be rigorous? According to what I shall call the standard view, a mathematical proof is rigorous if and only if it can be routinely translated into a formal proof. The standard view is almost an orthodoxy among contemporary mathematicians, and is endorsed by many logicians and philosophers, but it has also been heavily criticized in the philosophy of mathematics literature. Progress on the debate between the proponents and opponents of the standard view is, however, currently blocked by a major obstacle, namely, the absence of a precise formulation of it. To remedy this deficiency, I undertake in this paper to provide a precise formulation and a thorough evaluation of the standard view of mathematical rigor. The upshot of this study is that the standard view is more robust to criticisms than it transpires from the various arguments advanced against it, but that it also requires a certain conception of how mathematical proofs are judged to be rigorous in mathematical practice, a conception that can be challenged on empirical grounds by exhibiting rigor judgments of mathematical proofs in mathematical practice conflicting with it.
DISTANCES BETWEEN FORMAL THEORIES
Authors: KHALED MOHAMED , SZÉKELY GERGELY , LEFEVER KOEN , FRIEND MICHÈLE 
Published: October 2019

AbstractIn the literature, there have been several methods and definitions for working out whether two theories are “equivalent” (essentially the same) or not. In this article, we do something subtler. We provide a means to measure distances (and explore connections) between formal theories. We introduce two natural notions for such distances. The first one is that of axiomatic distance, but we argue that it might be of limited interest. The more interesting and widely applicable notion is that of conceptual distance which measures the minimum number of concepts that distinguish two theories. For instance, we use conceptual distance to show that relativistic and classical kinematics are distinguished by one concept only.
Compact UWB monopole antenna with reconfigurable band-notch characteristics
Authors: Han Liping , Chen Jing , Zhang Wenmei 
Published: October 2019

AbstractA compact ultra-wideband (UWB) monopole antenna with reconfigurable band-notch characteristics is demonstrated in this paper. It is comprised of a modified rectangular patch and a defected ground plane. The band-notch property in the WiMAX and WLAN bands is achieved by etching an open-ended slot on the radiating patch and an inverted U-shaped slot on the ground plane, respectively. To obtain the reconfigurable band-notch performance, two PIN diodes are inserted in the slots, and then the notch-band can be switched by changing the states of the PIN diodes. The antenna has a compact size of 0.47 λ1 × 0.27 λ1. The simulated and measured results indicate that the antenna can operate at a UWB mode, two single band-notch modes, and a dual band-notch mode. Moreover, stable radiation patterns are obtained.
Dynamics of arbuscular mycorrhizal fungi in relation to root colonization, spore density, and soil properties among different spreading stages of the exotic plant threeflower beggarweed (Desmodium triflorum) in aZoysia tenuifolialawn
Authors: Han Xiaoge , Xu Changchao , Wang Yutao , Huang Dan , Fan Qiang , Xin Guorong , Müller Christoph 
Published: October 2019

AbstractWeed invasion is a prevailing problem in modestly managed lawns. Less attention has been given to the exploration of the role of arbuscular mycorrhizal fungi (AMF) under different invasion pressures from lawn weeds. We conducted a four-season investigation into aZoysia tenuifoliaWilld. ex Thiele (native turfgrass)–threeflower beggarweed [Desmodium triflorum(L.) DC.] (invasive weed) co-occurring lawn. The root mycorrhizal colonizations of the two plants, the soil AM fungal communities and the spore densities under five different coverage levels ofD. triflorumwere investigated.Desmodium triflorumshowed significantly higher root hyphal and vesicular colonizations than those ofZ. tenuifolia, while the root colonizations of both species varied significantly among seasons. The increased coverage ofD. triflorumresulted in the following effects: (1) the spore density initially correlated with mycorrhizal colonizations ofZ. tenuifoliabut gradually correlated with those ofD. triflorum. (2) Correlations among soil properties, spore densities, and mycorrhizal colonizations were more pronounced in the higher coverage levels. (3) Soil AMF community compositions and relative abundances of AMF operational taxonomic units changed markedly in response to the increased invasion pressure. The results provide strong evidence thatD. triflorumpossessed a more intense AMF infection thanZ. tenuifolia, thus giving rise to the altered host contributions to sporulation, soil AMF communities, relations of soil properties, spore densities, and root colonizations of the two plants, all of which are pivotal for the successful invasion ofD. triflorumin lawns.
Dietary intake of tryptophan tied emotion-related impulsivity in humans
Authors: Javelle Florian , Li Descartes , Zimmer Philipp , Johnson Sheri L. 
Published: October 2019

Abstract. Emotion-related impulsivity, defined as the tendency to say or do things that one later regret during periods of heightened emotion, has been tied to a broad range of psychopathologies. Previous work has suggested that emotion-related impulsivity is tied to an impaired function of the serotonergic system. Central serotonin synthesis relies on the intake of the essential amino acid, tryptophan and its ability to pass through the blood brain barrier. Objective: The aim of this study was to determine the association between emotion-related impulsivity and tryptophan intake. Methods: Undergraduate participants (N = 25, 16 women, 9 men) completed a self-rated measure of impulsivity (Three Factor Impulsivity Index, TFI) and daily logs of their food intake and exercise. These data were coded using the software NutriNote to evaluate intakes of tryptophan, large neutral amino acids, vitamins B6/B12, and exercise. Results: Correlational analyses indicated that higher tryptophan intake was associated with significantly lower scores on two out of three subscales of the TFI, Pervasive Influence of Feelings scores r = –.502, p < . 010, and (lack-of) Follow-Through scores, r = –.407, p < . 050. Conclusion: Findings provide further evidence that emotion-related impulsivity is correlated to serotonergic indices, even when considering only food habits. It also suggests the need for more research on whether tryptophan supplements might be beneficial for impulsive persons suffering from a psychological disorder.
Math Homework Purpose Scale
Authors: Sun Meilu , Du Jianxia , Xu Jianzhong 
Published: October 2019

Abstract. The present study evaluated the psychometric properties of the Math Homework Purpose Scale (MHPS). After randomly splitting the sample ( N = 854) into two subsamples ( n = 427 and n = 427), we carried out exploratory factor analysis (EFA) on subsample 1 and confirmatory factor analysis (CFA) on subsample 2. The Kaiser-Meyer Olkin value of .88 indicated that EFA was appropriate for subsample 1. EFA results showed that a three-factor solution explained 72.2% of the variance. All ten of the MHPS items loaded quite substantially on three factors labeled Academic, Self-Regulatory, and Approval-Seeking. CFA results further showed that the MHPS was composed of three factors: Academic, Self-Regulatory, and Approval-Seeking. From this adequate level of measurement invariance, we further examined the latent mean difference across gender for the entire sample. Our findings showed no statistically significant mean differences in Academic, Self-Regulatory, and Approval-Seeking across gender. In addition, the HMPS was found to have adequate alpha reliability coefficients and omega coefficients. Concerning the validity evidence of the MHPS, Academic, Self-Regulatory, and Approval-Seeking purposes were positively correlated with homework effort, homework completion, and math achievement. The present study provides solid evidence that the MHPS is a reliable and valid measurement of math homework purposes.
Defining and distinguishing infant behavioral states using acoustic cry analysis: is colic painful?
Authors: Parga Joanna J. , Lewin Sharon , Lewis Juanita , Montoya-Williams Diana , Alwan Abeer , Shaul Brianna , Han Carol , Bookheimer Susan Y. , Eyer Sherry , Dapretto Mirella , Zeltzer Lonnie , Dunlap Lauren , Nookala Usha , Sun Daniel , Dang Bianca H. , Anderson Ariana E. 
Published: October 2019

AbstractBackgroundTo characterize acoustic features of an infant’s cry and use machine learning to provide an objective measurement of behavioral state in a cry-translator. To apply the cry-translation algorithm to colic hypothesizing that these cries sound painful.MethodsAssessment of 1000 cries in a mobile app (ChatterBabyTM). Training a cry-translation algorithm by evaluating >6000 acoustic features to predict whether infant cry was due to a pain (vaccinations, ear-piercings), fussy, or hunger states. Using the algorithm to predict the behavioral state of infants with reported colic.ResultsThe cry-translation algorithm was 90.7% accurate for identifying pain cries, and achieved 71.5% accuracy in discriminating cries from fussiness, hunger, or pain. The ChatterBaby cry-translation algorithm overwhelmingly predicted that colic cries were most likely from pain, compared to fussy and hungry states. Colic cries had average pain ratings of 73%, significantly greater than the pain measurements found in fussiness and hunger (p < 0.001, 2-samplettest). Colic cries outranked pain cries by measures of acoustic intensity, including energy, length of voiced periods, and fundamental frequency/pitch, while fussy and hungry cries showed reduced intensity measures compared to pain and colic.ConclusionsAcoustic features of cries are consistent across a diverse infant population and can be utilized as objective markers of pain, hunger, and fussiness. The ChatterBaby algorithm detected significant acoustic similarities between colic and painful cries, suggesting that they may share a neuronal pathway.
Prebiotic condensation through wet–dry cycling regulated by deliquescence
Authors: Campbell Thomas D. , Febrian Rio , McCarthy Jack T. , Kleinschmidt Holly E. , Forsythe Jay G. , Bracher Paul J. 
Published: October 2019

AbstractWet–dry cycling is widely regarded as a means of driving condensation reactions under prebiotic conditions to generate mixtures of prospective biopolymers. A criticism of this model is its reliance on unpredictable rehydration events, like rainstorms. Here, we report the ability of deliquescent minerals to mediate the oligomerization of glycine during iterative wet–dry cycles. The reaction mixtures evaporate to dryness at high temperatures and spontaneously reacquire water vapor to form aqueous solutions at low temperatures. Deliquescent mixtures can foster yields of oligomerization over ten-fold higher than non-deliquescent controls. The deliquescent mixtures tightly regulate their moisture content, which is crucial, as too little water precludes dissolution of the reactants while too much water favors hydrolysis over condensation. The model also suggests a potential reason why life evolved to favor the enrichment of potassium: so living systems could acquire and retain sufficient water to serve as a solvent for biochemical reactions.
Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
Authors: Lombardi Alyssa A. , Gibb Andrew A. , Arif Ehtesham , Kolmetzky Devin W. , Tomar Dhanendra , Luongo Timothy S. , Jadiya Pooja , Murray Emma K. , Lorkiewicz Pawel K. , Hajnóczky György , Murphy Elizabeth , Arany Zoltan P. , Kelly Daniel P. , Margulies Kenneth B. , Hill Bradford G. , Elrod John W. 
Published: October 2019

AbstractFibroblast to myofibroblast differentiation is crucial for the initial healing response but excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to understand the mechanisms underlying myofibroblast formation. Here we report that mitochondrial calcium (mCa2+) signaling is a regulatory mechanism in myofibroblast differentiation and fibrosis. We demonstrate that fibrotic signaling alters gating of the mitochondrial calcium uniporter (mtCU) in a MICU1-dependent fashion to reduce mCa2+ uptake and induce coordinated changes in metabolism, i.e., increased glycolysis feeding anabolic pathways and glutaminolysis yielding increased α-ketoglutarate (αKG) bioavailability. mCa2+-dependent metabolic reprogramming leads to the activation of αKG-dependent histone demethylases, enhancing chromatin accessibility in loci specific to the myofibroblast gene program, resulting in differentiation. Our results uncover an important role for the mtCU beyond metabolic regulation and cell death and demonstrate that mCa2+ signaling regulates the epigenome to influence cellular differentiation.
Restoration of visual function by transplantation of optogenetically engineered photoreceptors
Authors: Garita-Hernandez Marcela , Lampič Maruša , Chaffiol Antoine , Guibbal Laure , Routet Fiona , Santos-Ferreira Tiago , Gasparini Sylvia , Borsch Oliver , Gagliardi Giuliana , Reichman Sacha , Picaud Serge , Sahel José-Alain , Goureau Olivier , Ader Marius , Dalkara Deniz , Duebel Jens 
Published: October 2019

AbstractA major challenge in the treatment of retinal degenerative diseases, with the transplantation of replacement photoreceptors, is the difficulty in inducing the grafted cells to grow and maintain light sensitive outer segments in the host retina, which depends on proper interaction with the underlying retinal pigment epithelium (RPE). Here, for an RPE-independent treatment approach, we introduce a hyperpolarizing microbial opsin into photoreceptor precursors from newborn mice, and transplant them into blind mice lacking the photoreceptor layer. These optogenetically-transformed photoreceptors are light responsive and their transplantation leads to the recovery of visual function, as shown by ganglion cell recordings and behavioral tests. Subsequently, we generate cone photoreceptors from human induced pluripotent stem cells, expressing the chloride pump Jaws. After transplantation into blind mice, we observe light-driven responses at the photoreceptor and ganglion cell levels. These results demonstrate that structural and functional retinal repair is possible by combining stem cell therapy and optogenetics.
Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
Authors: Zhong Yifei , Lee Kyung , Deng Yueyi , Ma Yueming , Chen Yiping , Li Xueling , Wei Chengguo , Yang Shumin , Wang Tianming , Wong Nicholas J. , Muwonge Alecia N. , Azeloglu Evren U. , Zhang Weijia , Das Bhaskar , He John Cijiang , Liu Ruijie 
Published: October 2019

AbstractArctigenin (ATG) is a major component ofFructus Arctii, a traditional herbal remedy that reduced proteinuria in diabetic patients. However, whether ATG specifically provides renoprotection in DKD is not known. Here we report that ATG administration is sufficient to attenuate proteinuria and podocyte injury in mouse models of diabetes. Transcriptomic analysis of diabetic mouse glomeruli showed that cell adhesion and inflammation are two key pathways affected by ATG treatment, and mass spectrometry analysis identified protein phosphatase 2 A (PP2A) as one of the top ATG-interacting proteins in renal cells. Enhanced PP2A activity by ATG reduces p65 NF-κB-mediated inflammatory response and high glucose-induced migration in cultured podocytes via interaction with Drebrin-1. Importantly, podocyte-specificPp2adeletion in mice exacerbates DKD injury and abrogates the ATG-mediated renoprotection. Collectively, our results demonstrate a renoprotective mechanism of ATG via PP2A activation and establish PP2A as a potential target for DKD progression.
Gate-tunable giant nonreciprocal charge transport in noncentrosymmetric oxide interfaces
Authors: Choe Daeseong , Jin Mi-Jin , Kim Shin-Ik , Choi Hyung-Jin , Jo Junhyeon , Oh Inseon , Park Jungmin , Jin Hosub , Koo Hyun Cheol , Min Byoung-Chul , Hong Seokmin , Lee Hyun-Woo , Baek Seung-Hyub , Yoo Jung-Woo 
Published: October 2019

AbstractA polar conductor, where inversion symmetry is broken, may exhibit directional propagation of itinerant electrons, i.e., the rightward and leftward currents differ from each other, when time-reversal symmetry is also broken. This potential rectification effect was shown to be very weak due to the fact that the kinetic energy is much higher than the energies associated with symmetry breaking, producing weak perturbations. Here we demonstrate the appearance of giant nonreciprocal charge transport in the conductive oxide interface, LaAlO3/SrTiO3, where the electrons are confined to two-dimensions with low Fermi energy. In addition, the Rashba spin–orbit interaction correlated with the sub-band hierarchy of this system enables a strongly tunable nonreciprocal response by applying a gate voltage. The observed behavior of directional response in LaAlO3/SrTiO3 is associated with comparable energy scales among kinetic energy, spin–orbit interaction, and magnetic field, which inspires a promising route to enhance nonreciprocal response and its functionalities in spin orbitronics.
Tailoring the component of protein corona via simple chemistry
Authors: Lu Xiang , Xu Peipei , Ding Hong-Ming , Yu You-Sheng , Huo Da , Ma Yu-Qiang 
Published: October 2019

AbstractControl over the protein corona of nanomaterials allows them to function better. Here, by taking graphene/gold as examples, we comprehensively assessed the association of surface properties with the protein corona. As revealed by in vitro measurements and computations, the interaction between graphene/gold and HSA/IgE was inversely correlated with the hydroxyl group availability, whereas the interaction between that and ApoE was comparatively less relevant. Molecular simulations revealed that the number and the distribution of surface hydroxyl groups could regulate the manner in which nanomaterials interact with proteins. Moreover, we validated that ApoE pre-adsorption before injection enhances the blood circulation of nanomaterials relative to their pristine and IgE-coated counterparts. This benefit can be attributed to the invulnerability of the complementary system provided by ApoE, whose encasement does not increase cytotoxicity. Overall, this study offers a robust yet simple way to create protein corona enriched in dysopsonins to realize better delivery efficacy.