bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Tests of a Combined Filter for NOx, Particulates, and SO2 Reduction
Authors: Walberer Julian , Giovanny Mateus , Meiller Martin , Weih Christoph , Hornung Andreas 
Published: August 2018

AbstractThe idea of this innovative filter concept is to combine three individual flue gas technology treatment systems into one product to be more economic and efficient. The central part of the filter is a ceramic filter candle, which is used for common dust separation. The ceramic filter material is activated with modified catalysts to enable selective catalytic reduction at low temperatures (150–200 °C). To reduce acid components while simultaneously increasing dust separation, the activated filter candle surface is precoated with an absorbent. The developed filter is suitable for many applications, especially decentralized applications such as solid biomass combustion or utilization of biofuels in combined heat and power engines, which are target markets. The production of the filter material and the practical test using exhaust gas from a dual fuel engine operating with biofuels are described.
Incorporation of a p‐Phenylene Unit into the Azuliporphyrinogens Frame—Oxidation and Ruthenium Cluster Coordination
Authors: Sprutta Natasza , Hassa Agnieszka , Białek Michał J. , Kodź‐Wichowska Karolina , Kupietz Kamil , Latos‐Grażyński Lechosław 
Published: August 2018

AbstractA porphyrinogen macrocycle incorporating two azulenes, phenylene and thiophene into the framework, joined by four C(sp3) atoms has been obtained as a mixture of six isomers. They were successfully separated and characterized spectroscopically. The identity of two of them was confirmed by X‐ray crystallography. One isomer was tested in reaction with [Ru3(CO)12] yielding exclusively π‐complex with two clusters attached to azulenes. The partial oxidation of porphyrinogens yielded dication with two unmodified meso bridges. The stepwise oxidation followed by reaction with water as nucleophile afforded the dicationic species with two hydroxyl groups and a trication with one OH group. The hydroxy‐dication can be reversibly transformed into hydroxy‐trication by addition of HBF4 etherate.
Synthesis of Aliphatic Carboxamides Mediated by Nickel NN2‐Pincer Complexes and Adaptation to Carbon‐Isotope Labeling
Authors: Neumann Karoline T. , Donslund Aske S. , Andersen Thomas L. , Nielsen Dennis U. , Skrydstrup Troels 
Published: August 2018

AbstractThe development of a nickel‐mediated aminocarbonylation utilizing NN2‐pincer Ni‐complexes, alkylzinc reagents, stoichiometric carbon monoxide and amines is described for the first time, which can be adapted to late‐stage carbon‐isotope labeling. This work expands the scope of the highly established palladium‐promoted version of the reaction, by allowing carbon‐sp3 fragments to take part in the three‐component reaction. Finally, the results obtained show a remarkable effect of the pincer ligand for the reductive elimination step with the amine, which is followed by 13C NMR spectroscopy studies.
An Efficient Ruthenium Catalyst Bearing Tetradentate Ligand for Hydrogenations of Carbon Dioxide
Authors: Zhang Feng‐Hua , Liu Chong , Li Wei , Tian Gui‐Long , Xie Jian‐Hua , Zhou Qi‐Lin 
Published: August 2018

AbstractA ruthenium complex with a tetradentate bipyridine ligand was proved to be a highly efficient catalyst for the conversions of CO2. Turnover numbers up to 300 000, 9800, and 2100 were achieved for the hydrogenations of CO2 to formamides, formamides to methanol and amines, and the direct hydrogenation of CO2 to methanol, respectively.
Three‐dimensional flow optimization algorithm in complex scene based on differential equation
Authors: Wang Xiaoying 
Published: August 2018

SummaryThe 3D flow problem in complex scene is solved based on the differential equation. Differential equation method in parallel was fully used to accelerate the computing. Different from previous methods, this method is more general for complex scene condition. First of all, the entire obstacle information graph was constructed by the solid cutting section generated in image space. The algorithm ensures the independence of the fluid computation and the whole geometric scene. Through the classification of all elements and combining complex scene, the corresponding value can be modified according to the correction factor of obstacles; in addition, the more compact the data format was adopted to make full use of the parallelism of the differential equation method. By compressing all scalar operations to the 4 color channels of texture, the drawing number required in 3D flow field calculation is reduced. The experimental results show that the algorithm is effective and efficient. This algorithm can calculate and display the discrete complex scene using a medium scale in real time.
A hierarchical key pre‐distribution scheme for fog networks
Authors: Bahrami Pooneh Nikkhah , Javadi Hamid H.S. , Dargahi Tooska , Dehghantanha Ali , Choo Kim‐Kwang Raymond 
Published: August 2018

SummarySecurity in fog computing is multi‐faceted, and one particular challenge is establishing a secure communication channel between fog nodes and end devices. This emphasizes the importance of designing efficient and secret key distribution scheme to facilitate fog nodes and end devices to establish secure communication channels. Existing secure key distribution schemes designed for hierarchical networks may be deployable in fog computing, but they incur high computational and communication overheads and thus consume significant memory. In this paper, we propose a novel hierarchical key pre‐distribution scheme based on “Residual Design” for fog networks. The proposed key distribution scheme is designed to minimize storage overhead and memory consumption while increasing network scalability. The scheme is also designed to be secure against node capture attacks. We also demonstrate that, in an equal‐size network, our scheme reduces node storage overhead significantly. Our research paves the way for building an efficient key management framework for secure communication within the hierarchical network of fog nodes and end devices.
EReinit: Scalable and efficient fault‐tolerance for bulk‐synchronous MPI applications
Authors: Chakraborty Sourav , Laguna Ignacio , Emani Murali , Mohror Kathryn , Panda Dhabaleswar K. , Schulz Martin , Subramoni Hari 
Published: August 2018

SummaryScientists from many different fields have been developing Bulk‐Synchronous MPI applications to simulate and study a wide variety of scientific phenomena. Since failure rates are expected to increase in larger‐scale future HPC systems, providing efficient fault‐tolerance mechanisms for this class of applications is paramount. The global‐restart model has been proposed to decrease the time of failure recovery in Bulk‐Synchronous applications by allowing a fast reinitialization of MPI. However, the current implementations of this model have several drawbacks: they lack efficiency; their scalability have not been shown; and they require the use of the MPI profiling interface, which precludes the use of tools. In this paper, we present EReinit, an implementation of the global‐restart model that addresses these problems. Our key idea and optimization is the co‐design of basic fault‐tolerance mechanisms such as failure detection, notification, and recovery between MPI and the resource manager in contrast to current approaches on which these mechanisms are implemented in MPI only. We demonstrate EReinit in three HPC programs and show that it is up to four times more efficient than existing solutions at 4,096 processes.
Profiling Interactome Networks with the HaloTag‐NAPPA In Situ Protein Array
Authors: Yazaki Junshi , Galli Mary , Kim Alice Y. , Ecker Joseph R. 
Published: August 2018

AbstractPhysical interactions between proteins and other molecules can be evaluated at a proteome scale using protein arrays, a type of high‐throughput pulldown assay. We developed a modified in situ protein array known as the nucleic acid programmable protein assay (NAPPA) that allows the screening of thousands of open reading frames (ORFs) at a lower cost, with less labor, and in less time than conventional protein arrays. The HaloTag‐NAPPA protein array can efficiently capture proteins expressed in situ on a glass slide using the Halo high‐affinity capture tag. Here, we describe the fabrication of the array using publicly available resources and detection of protein‐protein interactions (PPIs) that can be used to generate a protein interactome map. The Basic Protocol includes procedures for preparing the plasmid DNA spotted on glass slides, in situ protein expression, and PPI detection. The supporting protocols outline the construction of vectors and preparation of ORF clones. © 2018 by John Wiley & Sons, Inc.
3D Porous Tin Created by Tuning the Redox Potential Acts as an Advanced Electrode for Sodium‐Ion Batteries
Authors: Wang Liubin , Ni Youxuan , Lei Kaixiang , Dong Huanhuan , Tian Sen , Li Fujun 
Published: August 2018

AbstractSodium‐ion batteries (SIBs) have attracted significant research interest for large‐scale electric energy storage. However, anodes with good rate capability and long cycle life are still lacking. Here, a three‐dimensional (3D) porous Sn on Cu foil (Sn/Cu) is prepared by tuning the redox potential of Cu+/Cu with a ligand of thiourea to trigger the replacement reaction between Cu and Sn2+. The as‐synthesized Sn/Cu is used as an integrated porous electrode and can be directly applied as an advanced freestanding electrode for SIBs. Such a unique structure can efficiently relieve the strain caused by sodiation/desodiation and benefit penetration of the electrolyte and diffusion of Na+. This is a merit of its large reversible capacity of about 700 mAh g−1 at 2500 mA g−1 for 400 cycles. A full battery of Sn/Cu//Na3(VO0.5)2(PO4)3F2 is constructed, which presents a high energy density of 311.7 Wh kg−1 and long lifespan of 200 cycles. This facile synthesis strategy and good electrochemical performance will encourage more investigations into structure design of functional materials.
In vitro antioxidant activities and inhibitory effects of phenolic extract of Senecio biafrae (Oliv and Hiern) against key enzymes linked with type II diabetes mellitus and Alzheimer's disease
Authors: Ajiboye Basiru O. , Ojo Oluwafemi A. , Okesola Marry A. , Akinyemi Ayodele J. , Talabi Justina Y. , Idowu Olajumoke T. , Fadaka Adewale O. , Boligon Aline A. , Anraku de Campos Marli M. 
Published: August 2018

AbstractThe phenolic extract of Senecio biafrae leaves was investigated to determine the in vitro antioxidant, phenolic profiles, and inhibition of key enzymes relevant to type II diabetes mellitus (α‐amylase and α‐glucosidase) and Alzheimer's disease (acetylcholinesterase and butrylcholinesterase). The phenolic extract demonstrated significant scavenging abilities against all in vitro antioxidant parameters assessed. Reversed‐phase HPLC of the extract revealed the presence of gallic acid, chlorogenic, caffeic acid, rutin, quercetin, and kaempferol. The extract also inhibited activities of α‐amylase (IC50 = 126.90 μg/ml), α‐glucosidase (IC50 = 139.66 μg/ml), acetylcholinesterase (IC50 = 347.22 μg/ml), and butrylcholinesterase (IC50 = 378.79 μg/ml), which may be attributed to the antioxidant potential of the extract and its phenolic composition. Therefore, this study suggests that the leaves of S. biafrae may be useful in the management of diabetes mellitus and Alzheimer's disease.
Eugenics Redux: “Reproductive Benefit” as a Rationale for Newborn Screening
Authors: Paul Diane B. 
Published: August 2018

AbstractIn recent years, as newborn screening has expanded to include conditions for which treatment is questionable, new rationales for screening have proliferated. One such rationale is the potential reproductive benefit to parents from the detection of a genetic condition or carrier status in infants. An unanticipated consequence of invoking knowledge of reproductive risk as a major benefit of screening has been to open newborn screening to the charge that it constitutes state‐sanctioned eugenics. Thus, an endeavor that had been viewed as the converse of state programs of selective breeding has come to be seen in some quarters as yet another of its incarnations. The result has been serious and self‐inflected harm to the reputation of newborn screening programs.
Single‐Gene Sequencing in Newborn Screening: Success, Challenge, Hope
Authors: Currier Robert J. 
Published: August 2018

AbstractSome state‐based newborn screening programs in the United States already use sequencing technology, as a secondary screening test for individual conditions rather than as a broad screening tool. Newborn screening programs sequence an individual gene, such as the cystic fibrosis transmembrane conductance regulator, which causes cystic fibrosis, after an initial biochemical test suggests that a baby might have a condition related to that gene. The experiences of state public health departments with individual‐gene sequencing illustrate both the usefulness of the technology and its complexities. Here I discuss how newborn screening programs investigate cystic fibrosis and, as another example, adrenoleukodystrophy through individual gene sequencing.
Serum albumin or body mass index: Which prognostic factor for survival in patients with acute myeloblastic leukaemia?
Authors: Filliatre‐Clement Lauriane , Broseus Julien , Muller Marc , Hosseini Kossar , Rotonda Christine , Schirmer Luciane , Roth‐Guepin Gabrielle , Bonmati Caroline , Feugier Pierre , Béné Marie‐Christine , Perrot Aurore 
Published: August 2018

AbstractObesity has been associated with an increased risk of developing acute myeloblastic leukaemia (AML). The outcome of AML patients could thus be dependent on their nutritional status that can be evaluated by the simple measurement of serum albumin (SA) and body mass index (BMI). These two parameters could have a value as prognostic factors to guide patients' management. We evaluated the association between SA levels, BMI, and survival, evaluated as overall survival (OS) and event‐free survival. Furthermore, we investigated the association between BMI, SA, and other prognostic factors of interest in AML. This retrospective single‐center study included 159 patients diagnosed with AML at Nancy Hospital between 2005 and 2013, treated with aracytine and anthracycline. Forty‐four percent of patients presented with normal weight while 56% were obese/overweight. Serum albumin levels were <30 g/L for 49 patients, and ≥30 g/L for 110. Thirty‐four patients with low SA levels were also obese. Favourable OS was associated with SA levels ≥30 g/L (HR = 0.467; 95% CI 0.230‐0.946; P = .034) but was not impacted by the BMI. Serum albumin levels appear to be an independent prognostic factor in AML and a better parameter than BMI for evaluating the nutritional status of patients at diagnosis.
Investigation of thermohydraulic performance of triple concentric‐tube heat exchanger with CuO/water nanofluid: Numerical approach
Authors: Amanuel Tarikayehu , Mishra Manish 
Published: August 2018

AbstractIn this study, numerical investigation of CuO/water nanofluids in a triple concentric‐tube heat exchanger has been carried out using a commercial CFD software. The primary objective of this study is to conduct a heat transfer and pressure drop characteristics of water‐based CuO nanofluids under turbulent flow regime. Reynolds number for the nanofluid has also been considered in the range of 2500 to 10,000 with a nanoparticle volume concentration of 0% to 3%. The effects of flow rate, volume concentration of nanoparticles, and flow arrangement on heat transfer performance of nanofluid have been studied for four flow arrangements. The comparison of the performance with and without nanofluid has been done. It was found that thermal performance and overall effectiveness increased with the increase in Reynolds number and volume concentration of nanoparticles in all the four flow arrangements for the considered range of operating parameters.
MIAC: A mobility intention auto‐completion model for location prediction
Authors: Yi Feng , Feng Guan , Wang Hongtao , Li Zhi , Sun Limin 
Published: August 2018

SummaryLocation prediction is essential to many commercial applications and enables appealing experience for business and governments. Many research work show that human mobility is highly predictable. However, existing work on location prediction reported limited improvements in using generalized spatio‐temporal features and unsatisfactory prediction accuracy for complex human mobility. To address these challenges, in this paper we propose a Mobility Intention and Auto‐Completion (MIAC) model. We extract those mobility patterns that generalize common spatio‐temporal features of all users, and use the mobility intentions as the hidden states from mobility dataset. A new predicting algorithm based on auto‐completion is then proposed. The experimental results on real‐world datasets demonstrate that the proposed MIAC model can properly capture the regularity of a user's mobility by simultaneously considering the spatial and temporal features. The comparison results also indicate that MIAC model significantly outperforms state‐of‐the‐art location prediction methods, and also can predicts long range locations.
Physical contact between mesenchymal stem cells and endothelial precursors induces distinct signatures with relevance to the very early phase of regeneration
Authors: Hafen Bettina , Wiesner Susanne , Schlegelmilch Katrin , Keller Alexander , Seefried Lothar , Ebert Regina , Walles Heike , Jakob Franz , Schütze Norbert 
Published: August 2018

AbstractMultipotent adult stem cells/precursor cells, especially of the mesenchymal and endothelial lineage, may have great potential for bone tissue engineering. Although their potential is highly recognized, not much is known about the underlying molecular mechanisms that initiate the regeneration process, connect osteogenesis, and angiogenesis and, finally, orchestrate renewal of bone tissue. Our study addressed these questions by generating two in vitro cell culture models to examine the changes in the global gene expression patterns of endothelial precursor cells and mesenchymal stem cells after 24 hours of either humoral (conditioned medium) or direct cell‐cell interaction (co‐culture). Endothelial precursor cells were isolated from human buffy coat and mesenchymal stem cells from the bone marrow of the femoral head. The comparison of the treated and control cells by microarray analyses revealed in total more than 1500 regulated genes, which were analyzed for their affiliation to angiogenesis and osteogenesis. Expression array analyses at the RNA and protein level revealed data with respect to regulated genes, pathways and targets that may represent a valid basis for further dissection of the systems biology of regeneration processes. It may also be helpful for the reconstitution of the natural composition of a regenerative microenvironment when targeting tissue regeneration both in vitro and in situ.
Association of neutrophil‐to‐lymphocyte ratio and natural killer cell activity revealed by measurement of interferon‐gamma levels in a healthy population
Authors: Kim Bo‐Ram , Chun Sejong , Cho Duck , Kim Kyeong‐Hee 
Published: August 2018

BackgroundWhile a method of assaying natural killer (NK) cell activity by measuring the amount of interferon (IFN)‐γ released from NK cells has been proposed, no data are available about the factors that influence IFN‐γ levels related to NK cell activity. NLR has recently been reported to be a predictor of several diseases. In the present study, we investigated the pre‐analytical variables for NK cell activity using measurements of IFN‐γ and the relationship between NLR and NK cell activity.MethodsThe NK cell activity was assessed with the measurement of IFN‐γ after stimulation with an NK cell‐specific stimulant (NK Vue™, ATgen, Sungnam, Korea). One hundred and six adult volunteers were recruited and analysis of their complete blood count data and serum C‐reactive protein was done. Blood sample from 59 of the participants was also used for analysis of lymphocyte subpopulations.ResultNatural killer cell activity varied widely (range, 44.2‐1775.6 pg/mL). NK cell activity was higher in females than in males (P = 0.014). NK cell activity decreased with increasing NLR (P = 0.004, r = −0.32) but NK cell activity showed no significant association with NK cell count or other lymphocyte subpopulations. NK cell activity levels according to CRP quartile were significantly different (P = 0.025).ConclusionWe have observed that NK cell activity when assessed by IFN‐γ level measurement was negatively correlating with NLR. This result can be helpful in interpreting or predicting NK cell activity in the clinical environment.
Change of miRNA expression profiles in patients with knee osteoarthritis before and after celecoxib treatment
Authors: Dong Zhao , Jiang Honghui , Jian Xiaofei , Zhang Weiguo 
Published: August 2018

BackgroundThis study aimed to investigate the change of circulating miRNA expression profiles in knee osteoarthritis (OA) patients before and after celecoxib treatment.MethodsTwo hundred and eighteen knee OA patients underwent celecoxib treatment for 6 weeks were enrolled. Plasma samples were obtained at baseline (W0) and at W6, and treatment efficacy were assessed by WOMAC index. In the exploration stage, miRNA expression profiles in plasma before and after treatment from 6 patients were detected by microarray. Subsequently, in the validation stage, 10 top differentially expressed miRNAs (DEMs) after and before treatment in microarray were further validated in all 218 patients by qPCR.ResultsIn the exploration stage, patients after treatment could be distinguished from them before treatment by miRNAs expression profiles by PCA plot and heatmap analysis, and 45 up‐regulated and 48 down‐regulated miRNAs were identified by volcano plot. In the validation stage, miR‐126‐5p and miR‐320a levels increased at W6 compared to W0, while miR‐155‐5p and miR‐146a‐5p levels decreased. WOMAC pain/stiffness/physical function scores were all decreased at W6 compared to W0, and 71% of patients achieved clinical response. The increase of miR‐126‐5p expression (W6‐W0) in clinical responders was much larger compared to nonclinical responders. And miRNA‐320a level declined in nonclinical responders while increased in clinical responders. Conversely, miRNA‐146a‐5p level increased in nonclinical responders while decreased in clinical responders.ConclusionCirculating miRNA expression profiles act as important roles in knee OA patients underwent celecoxib treatment, and miR‐126‐5p, miR‐320a as well as miR‐146a‐5p might correlate with treatment response to celecoxib.