bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-Reported Outcomes in Online Communications on Statins, Memory, and Cognition: Qualitative Analysis Using Online Communities
Authors: Timimi Farris , Ray Sara , Jones Erik , Aase Lee , Hoffman Kathleen 
Published: September 2019

Background
In drug development clinical trials, there is a need for balance between restricting variables by setting eligibility criteria and representing the broader patient population that may use a product once it is approved. Similarly, although recent policy initiatives focusing on the inclusion of historically underrepresented groups are being implemented, barriers still remain. These limitations of clinical trials may mask potential product benefits and side effects. To bridge these gaps, online communication in health communities may serve as an additional population signal for drug side effects.

Objective
The aim of this study was to employ a nontraditional dataset to identify drug side-effect signals. The study was designed to apply both natural language processing (NLP) technology and hands-on linguistic analysis to a set of online posts from known statin users to (1) identify any underlying crossover between the use of statins and impairment of memory or cognition and (2) obtain patient lexicon in their descriptions of experiences with statin medications and memory changes.

Methods
Researchers utilized user-generated content on Inspire, looking at over 11 million posts across Inspire. Posts were written by patients and caregivers belonging to a variety of communities on Inspire. After identifying these posts, researchers used NLP and hands-on linguistic analysis to draw and expand upon correlations among statin use, memory, and cognition.

Results
NLP analysis of posts identified statistical correlations between statin users and the discussion of memory impairment, which were not observed in control groups. NLP found that, out of all members on Inspire, 3.1% had posted about memory or cognition. In a control group of those who had posted about TNF inhibitors, 6.2% had also posted about memory and cognition. In comparison, of all those who had posted about a statin medication, 22.6% (P<.001) also posted about memory and cognition. Furthermore, linguistic analysis of a sample of posts provided themes and context to these statistical findings. By looking at posts from statin users about memory, four key themes were found and described in detail in the data: memory loss, aphasia, cognitive impairment, and emotional change.

Conclusions
Correlations from this study point to a need for further research on the impact of statins on memory and cognition. Furthermore, when using nontraditional datasets, such as online communities, NLP and linguistic methodologies broaden the population for identifying side-effect signals. For side effects such as those on memory and cognition, where self-reporting may be unreliable, these methods can provide another avenue to inform patients, providers, and the Food and Drug Administration.
Konflik dalam Kelompok Tani Gadih Basanai di Kenagarian IV Koto Hilir Kecamatan Batang Kapas, Kabupaten Pesisir Selatan
Authors: Maiwulandari Citra , Susilawati Nora 
Published: September 2019

Penelitian ini dilatarbelakangi karena isu korupsi yang dilakukan oleh pengurus kelompok tani gadih basanai. Penelitian ini akan dianalisis dengan menggunakan Teori Konflik oleh Lewis Coser. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif dan pemilihan informan dengan teknik purposive sampling atau penarikan sampel secara sengaja agar mendapatkan data yang lebih akurat. Data pada penelitian ini dikumpulkan dengan cara observasi, wawancara, studi dokumentasi kemudian dianalisis menggunakan teknik analisis data dari Miles dan Huberman. Berdasarkan penelitian hasilnya menunjukkan bahwa bentuk-bentuk konflik yang terjadi di Kelompok Tani Gadih Basanai di isukan adanya korupsi yang menyebabkan terjadinya kekacauan dalam management keuangan, sistem kepengurusan berantakan dan perselisihan sesama pengurus kelompok tani, pengurus dengan anggota dan sesama anggota. Upaya atau solusi dari konflik yang terjadi dalam kelompok tani gadih basanai yaitu merevitalisasi kelompok tani dan menentukan anggaran-anggaran dalam kelompok tani sehingga lebih jelas management keuangan, sistem kepengurusan serta diresmikan oleh pemerintah nagari IV Koto Hilir.
Dinamika Perubahan Paradigma Pendidikan: Studi tentang Kesiapan Guru Pendidikan Agama Islam di SD/MI di Wilayah Kabupaten Banyumas dalam Menerapkan Pendekatan Pembelajaran Saintifik dan Penilaian Otentik Kurikulum 2013
Authors: Suparjo Suparjo 
Published: September 2019

Abstract: This study was aimed at explaining the changes of educationparadigm among islamic education teachers in elementary schools and islamicelementary schools in Banyumas Regency, shown by teacher’s readiness inimplementing Curriculum 2013, especially in applying scientific method andauthentic assessment. This research used mixed methods, quantitative andqualitative methods. The research found that Islamic education teachers in bothgeneral and islamic elementary schools are ready to implement Curriculum 2013.In addition, they are also ready apply and develop scientific learning model andauthentic assessment as well as adapt to the new education paradigm. However,because of the lack of socialization, training, and facilities, they get some difficultiesin mastering knowledge about the curriculum and its implementation. From theresearch findings, it can be concluded that curriculum can be a starting point tochange the paradigm and practices of education as far as it is prepared and facilitated.Keywords: education paradigm, teacher, religious education, curriculum 2013.
Abstrak: Hasil penelitian ini adalah bahwa guru PAI di SD maupun guru MI sudahsiap mengimplementasikan Kurikulum 2013, merasa mampu menerapkannyadalam mengembangkan model pembelajaran saintifik, penilaian otentik dan menyesuaikannyadengan paradigma baru pendidikan. Hanya saja, karena sosialisasidan pelatihan serta instrumen pendukung kurikulum belum tersedia secara makismal.Karenanya, mereka mengalami kendala dalam pengetahuan dan kemampuanmengimplementasikannya. Berdasarkan temuan tersebut dapat diambil kesimpulanbesar yakni, kurikulum mampu menjadi titik awal mengubah paradigmadan praktik pendidikan sesuai tuntutan idealisme pendidikan itu sendiri sejauhdilakukan persiapan dan fasilitas pendukung yang memadai.Kata Kunci: paradigma pendidikan, guru, pendidikan agama, dan kurikulum2013
Detection of lipoprotein X (LPX) – a challenge in patients with severe hypercholesterolaemia
Authors: Ćwiklińska Agnieszka , Mickiewicz Agnieszka , Kowalski Robert , Kortas-Stempak Barbara , Kuchta Agnieszka , Mucha Krzysztof , Makowiecki Michał , Gliwińska Anna , Lewandowski Krzysztof , Pączek Leszek , Fijałkowski Marcin , Gruchała Marcin , Jankowski Maciej 
Published: September 2019

SummaryBackgroundLipoprotein X (LpX) is an abnormal lipoprotein fraction, which can be detected in patients with severe hypercholesterolaemia and cholestatic liver disease. LpX is composed largely of phospholipid and free cholesterol, with small amounts of triglyceride, cholesteryl ester and protein. There are no widely available methods for direct measurement of LpX in routine laboratory practice. We present the heterogeneity of clinical and laboratory manifestations of the presence of LpX, a phenomenon which hinders LpX detection.MethodsThe study was conducted on a 26-year-old female after liver transplantation (LTx) with severely elevated total cholesterol (TC) of 38 mmol/L and increased cholestatic liver enzymes. TC, free cholesterol (FC), cholesteryl esters (CE), triglycerides, phospholipids, HDL-C, LDL-C, and apolipoproteins AI and B were measured. TC/apoB and FC:CE ratios were calculated. Lipoprotein electrophoresis was performed using a commercially available kit and laboratory-prepared agarose gel.ResultsCommercially available electrophoresis failed to demonstrate the presence of LpX. Laboratory-prepared gel clearly revealed the presence of lipoproteins with γ mobility, characteristic of LpX. The TC/apoB ratio was elevated and the CE level was reduced, confirming the presence of LpX. Regular lipoprotein apheresis was applied as the method of choice in LpX disease and a bridge to reLTx due to chronic liver insufficiency.ConclusionsThe detection of LpX is crucial as it may influence the method of treatment. As routinely available biochemical laboratory tests do not always indicate the presence of LpX, in severe hypercholesterolaemia with cholestasis, any discrepancy between electrophoresis and biochemical tests should raise suspicions of LpX disease.
Rosiglitazone-induced changes in the oxidative stress metabolism and fatty acid composition in relation with trace element status in the primary adipocytes
Authors: Aydemir Duygu , Sarayloo Ehsan , Ulusu Nuriye Nuray 
Published: September 2019

Summary

Background
Metabolic syndrome, obesity and type 2 diabetes are metabolic disorders characterized by the insulin resistance and the impairment in the insulin secretion. Since impairment in the oxidative stress and adipocyte metabolism contribute to the formation of obesity and diabetes, targeting adipose tissue can be considered as an effective approach to fight against them. Rosiglitazone is used for treatment for patients with type 2 diabetes via inducing lipogenesis and transdifferentiation of white adipose tissue into brown adipose tissue. Since the development of such therapeutics is required to control the formation and function of brown fat cells, we aimed to reveal possible molecular mechanisms behind rosiglitazone induced biochemical changes in the adipose tissue.

Methods
Cells were expanded in the adipocyte culture medium supplemented with 5 μg/mL insulin following 2 days’ induction. After those cells were treated with rosiglitazone 0, 0.1 3 mol/L and 10 μmol/L rosiglitazone for 48 hours and at 8th day, cells were collected and stored at -80 °C. Then the cells were used to evaluate antioxidant enzyme activities, mineral and trace element levels and fatty acid composition.

Results
Glucose-6-phosphate dehydrogenase and glutathione reductase significantly reduced in rosiglitazone-treated groups compared to the control. Na, Mg, K, Ca, Cr, Fe, Ni, Cu, Zn, Rb, Sr, Cs, Ba and Pb were determined in the cell lysates via ICP-MS. Also, relative FAME content decreased in the rosiglitazone-treated groups compared to the control.

Conclusions
Rosiglitazone treatment at low doses showed promising results which may promote brown adipose tissue formation.
La evaluación al desempeño directivo y docente como una oportunidad para mejorar la calidad educativa
Authors: Cóndor Beatriz Hortencia , Remache Bunci Manuel 
Published: September 2019

La investigación indaga las percepciones de directivos y docentes sobre la calidad educativa y las principales dificultades que enfrenta la educación en la actualidad. También evalúa el desempeño del docente en el aula, mediante la observación de la clase y la reflexión pedagógica permanente de los procesos de enseñanza. Siendo esta última una tarea prioritaria de los organismos de control. En la investigación fue necesario revisar las bases conceptuales inherentes al desempeño docente, acompañamiento pedagógico, liderazgo, estrategias de aprendizaje y la calidad de la enseñanza. La metodología de estudio se fundamentó en el enfoque cualitativo, apoyada en dos técnicas. La observación de la clase con el instrumento técnico denominado ficha de observación áulica, que permitió visualizar cómo se llevan a cabo los procesos de enseñanza y aprendizaje. Y la entrevista semiestructurada aplicada a una muestra de 43 investigados entre docentes y directivos de la Zona 9, Provincia de Pichicha. Los resultados obtenidos a partir de estos instrumentos permitieron conocer las fortalezas y debilidades reales existentes en la enseñanza. Finalmente, se determinó que las actividades propuestas para desarrollar la clase guardan escasa relación unas con otras, no atienden a un enfoque pedagógico, ni a un método, técnica, estrategia o proceso de enseñanza. Además, la enseñanza se centra en el docente, quien expone sus saberes, mientras la participación del estudiante es mínima. Estos y otros hallazgos permitieron concluir que el desempeño directivo y docente influyen en el aprendizaje y el mantener prácticas pedagógicas tradicionales no contribuirá al mejoramiento de la calidad de la enseñanza.
APLIKASI THEORY HIERARKI MASLOW TERHADAP PRODUKTIVITAS KERJA KARYAWAN (Study Kasus PT. BINES RAYA Cabang Cirebon)
Authors: Gozali Gozali Gozali , Miftahusururi Miftahusururi Miftahusururi 
Published: September 2019

Tujuan yang ingin dicapai dengan dilakukannya penelitian ini adalah untuk melihat sejauh mana motivasi mempengaruhi produktivitas kerja karyawan serta untuk mengetahui variabel mana yang paling dominan mempengaruhi produktivitas kerja karyawan pada Perusahaan PT.BINES RAYA Cirebon. Dalam Penelitian Teori Motivasi yang digunakan adalah Teori Hierarki Maslow yang terbagi menjadi 5 kebutuhan diantaranya : Kebutuhan Fisiologis, Rasa aman, Sosial, Harga diri dan Aktualisasi diri.
Permasalahan yang dihadapi oleh perusahaan apakah motivasi mempengaruhi produktivitas kerja karyawan khususnya pada Perusahaan PT.BINES RAYA Cirebon serta variabel manakah yang paling dominan mempengaruhi produktivitas kerja karyawan pada Perusahaan PT.BINES RAYACirebon. Dalam penelitian ini sample yang digunakan adalah 25% dari total populasi yang berjumlah 200 Karyawan, yaitu 50 Responden. Dalam penelitian ini tehnik pengambilan datanya dengan mendistribusikan kuesioner.
Dari hasil analisis regresi yang dilakukan menunjukkan bahwa kelima variabel motivasi kerja terhadap produktivitas kerja, maka diperoleh kebutuhan fisiologis (X1) = 0.098, kebutuhan akan rasa aman (X2) = 0.181, kebutuhan sosial (X3) = 0.035, kebutuhan Harga diri (X4) = -0,260, kebutuhan aktualisasi diri (X5) = 0.185. Sedangkan variabel yang paling dominan mempengaruhi produktivitas kerja karyawan adalah kebutuhan Aktualisasi diri sebesar 0.185.
Berdasarkan uji t hitung didapatkan : yaitu kebutuhan fisiologis untuk nilai thitung sebesar (0,842) hasil ini tidak berengaruh bermakna terhadap produktivitas dimana nilai t table 2,015, kebutuhan akan rasa aman untuk nilai thitung sebesar (1,694) hasil ini tidak berengaruh bermakna terhadap produktivitas dimana nilai t table 2,015, kebutuhan sosial untuk nilai thitung sebesar (0,268) hasil ini tidak berengaruh bermakna terhadap produktivitas dimana nilai t table 2,015, kebutuhan Harga diri untuk nilai thitung sebesar (-1,949) hasil ini tidak berengaruh bermakna terhadap produktivitas dimana nilai t table 2,015, kebutuhan aktualisasi diri untuk nilai thitung sebesar (2,064) hasil ini berengaruh bermakna terhadap produktivitas dimana nilai t table 2,015. Namun berdasarkan uji f secara bersama-sama variabel Motivasi kebutuhan yaitu Fisiologis, Rasa aman, Sosial, Harga diri dan Aktualisasi diri berpengaruh terhadap produktivitas kerja dilihat dari nilai fhitung > f tabel. (4,581>2,427).

Kata Kunci : Kebutuhan Fisiologis, Kebutuhan akan Rasa Aman, Kebutuhan Sosial, Kebutuhan akan Prestasi, Kebutuhan Aktualisasi Diri, Produktivitas Kerja
PENGARUH MOTIVASI DAN KETERAMPILAN KERJA TERHADAP PRODUKTIVITAS KERJA SALES PROMOTION PT. PARAGON TECHNOLOGY AND INNOVATION DEPARTEMEN STORE
Authors: Badawi Badawi , Afifah Hilyatul 
Published: September 2019

Penelitian ini bertujuan untuk mengetahui: (1) pengaruh motivasi kerja terhadap produktivitas kerja, (2) pengaruh keterampilan kerja terhadap produktivitas kerja, (3) pengaruh motivasi kerja dan keterampilan kerja terhadap produktivitas kerja. Populasi penelitian ini adalah karyawan PT. Paragon Technology yang berjumlah 35, populasi ini sekaligus dijadikan sebagai sampel, yaitu jumlah populasi sama dengan jumlah sampel. Metode pengumpulan data dengan metode kuesioner. Uji validitas menggunakan uji korelasi Pearson Product Moment dan uji reliabilitas menggunakan Cronbachâ€™s Alpha. Uji hipotesis menggunakan analisis uji t dan uji f.
Hasil penelitian ini menunjukkan : (1) motivasi kerja memiliki pengaruh terhadap keputusan produktivitas kerja, (2) keterampilan kerja berpengaruh terhadap produktivitas kerja, (3) dengan demikian dalam penelitian ini motivasi dan keterampilan kerja berpengaruh terhadap produktivitas kerja.
Kata Kunci : Motivasi, Keterampilan Kerja, Produktivitas Kerja
Você na Tela: o Youtube e a Compulsão por ser Percebido
Authors: Pacífico Marsiel , Gomes Luiz Roberto 
Published: September 2019

Dentro do infinito universo de possibilidades do ciberespaço, um portal de vídeos destaca-se de modo inequívoco: o Youtube. Atualmente contando como segundo maior número de acessos no mundo, o site também apresenta uma significativa quantidade de usuários no Brasil: somos o segundo maiorconsumidor mundial das publicações do portal, com destaque para o perfil jovem deste público. Mas afinal, o que difere o Youtube de outros sites paraque alcançasse tamanho sucesso? Para a análise desta questão, buscaremos neste artigo, a partir de convergências com valores e comportamentosensejados no nosso contexto social, compreender os motivos que favoreceram a expansão do Youtube, além de problematizarmos as consequênciasformativas decorrentes do processo.
PERBEDAAN PENGETAHUAN REMAJA PUTRI USIA 17 – 19 TAHUN TENTANG IMUNISASI HUMAN PAPILOMA VIRUS ( HPV ) DI AKADEMI KEBIDANAN DHARMA HUSADA KEDIRI
Authors: HERDYANA ERMA , Latrifida Richana 
Published: September 2019

Imunisasi HPV adalah pencegahan primer untuk kanker serviks, bekerja meningkatkan kemampuan sistem imun untuk mengenali dan menghancurkan virus ketika masuk kedalam tubuh sebelum terjadi infeksi. Banyak remaja tidak memiliki pengetahuan yang akurat tentang kesehatan reproduksi, dimana kanker serviks yang sering menyerang kesehatan reproduksi wanita. Penelitian ini bertujuan untuk mengetahui perbedaan pengetahuan remaja putri tentang imunisasi HPV sebelum dan sesudah diberi penyuluhan.
Jenis penelitian ini menggunakan desain penelitian analitik komparatif dan rancangan penelitian pra-eksperimental dengan penelitian pra-pasca test. Populasi penelitian adalah 113 remaja putri usia 17-19 tahun. Pengambilan sampel menggunakan teknik total sampling. Dalam penelitian ini variabel independennya adalah penyuluhan, dan variabel dependennya adalah pengetahuan remaja putri usia 17-19 tahun tentang imunisasi HPV. Pengolahan data dengan editing, coding, scoring, tabulating. Data diperoleh dari kuesioner yang diolah dan dianalisis menggunakan uji wilcoxon.
Hasil penelitian menunjukkan bahwa sebelum diberi penyuluhan tidak ada responden (0%) yang memiliki pengetahuan yang baik tentang imunisasi HPV, sedangkan sesudah diberi penyuluhan jumlah responden dengan pengetahuan baik meningkat menjadi 94 responden (83,19%). Sedangkan hasil uji statistik dengan menggunakan uji wilcoxon, diperoleh hasil nilai Z sebesar -9.195 dengan tingkat signifikansi (σ) sebesar 0,000 (σ ≤ 0,05).
Dari hasil penelitian tersebut diperoleh kesimpulan bahwa ada perbedaan yang signifikan antara pengetahuan remaja putri usia 17-19 tahun tentang imunisasi HPV sebelum dan sesudah diberi penyuluhan. Dengan demikian diharapkan remaja putri lebih termotivasi untuk menambah informasi dan pengetahuan tentang imunisasi HPV melalui tenaga kesehatan, media massa atau sumber-sumber lain serta dapat mengaplikasikan pengtahuan yang telah diperoleh dalam kehidupan sehari-hari.
Pengetahuan, Remaja putri, Imunisasi HPV, Penyuluhan
The Shallow Decay Segment of GRB X-Ray Afterglow Revisited
Authors: Zhao Litao , Zhang Binbin , Gao He , Lan Lin , Lü Houjun , Zhang Bing 
Published: September 2019

Abstract
Based on the early-year observations from Neil Gehrels Swift Observatory, Liang et al. performed a systematic analysis for the shallow decay component of gamma-ray bursts (GRBs) X-ray afterglow, in order to explore its physical origin. Here we revisit the analysis with an updated sample (with Swift/XRT GRBs between 2004 February and 2017 July). We find that with a larger sample, (1) the distributions of the characteristic properties of the shallow decay phase (e.g., t

b
, S
X, ΓX,1, and α
X,1) still accord with normal or lognormal distribution; (2) ΓX,1 and Γ
γ
still show no correlation, but the tentative correlations of durations, energy fluences, and isotropic energies between the gamma-ray and X-ray phases still exist; (3) for most GRBs, there is no significant spectral evolution between the shallow decay segment and its follow-up segment, and the latter is usually consistent with the external-shock models; (4) assuming that the central engine has a power-law luminosity release history as

, we find that the value q is mainly distributed between −0.5 and 0.5, with an average value of 0.16 ± 0.12; (5) the tentative correlation between

and

disappears, so that the global three-parameter correlation (

) becomes less significant; (6) the anticorrelation between L
X and

and the three-parameter correlation (

) indeed exist with a high confidence level. Overall, our results are generally consistent with Liang et al., confirming their suggestion that the shallow decay segment in most bursts is consistent with an external forward shock origin, probably due to a continuous energy injection from a long-lived central engine.
Changes in Solar Rotation over Two Solar Cycles
Authors: Basu Sarbani , Antia H. M. 
Published: September 2019

Abstract
We use helioseismic data from ground- and space-based instruments to analyze how solar rotation has changed since the beginning of solar Cycle 23 with emphasis on studying the differences between Cycles 23 and 24. We find that the nature of solar rotation is indeed different for the two cycles. While the changes in the latitudinally independent component follows solar-cycle indices, some of the other components have a more complicated behavior. There is a substantial change in the behavior of the solar zonal flows and their spatial gradients too. While the zonal flows in Cycle 24 are weaker in general than those in Cycle 23, there are clear signs of the emergence of Cycle 25. We have also investigated the properties of the solar tachocline, in particular, its position, width, and the change (or jump) in the rotation rate across it. We find significant temporal variation in the change of the rotation rate across the tachocline. We also find that the changes in solar Cycle 24 were very different from those of Cycle 23. We do not find any statistically significant change in the position or the width of the tachocline.
Infrared Interferometric Three-dimensional Diagnosis of the Atmospheric Dynamics of the AGB Star R Dor with VLTI/AMBER*
Authors: Ohnaka Keiichi , Weigelt Gerd , Hofmann Karl-Heinz 
Published: September 2019

Abstract
The mechanism of mass loss in late evolutionary stages of low- and intermediate-mass stars is not yet well understood. Therefore, it is crucial to study the dynamics of the region within a few R
⋆, where the wind acceleration is considered to take place. We present a three-dimensional diagnosis of the atmospheric dynamics of the closest asymptotic giant branch star R Dor from the low photospheric layers to the extended outer atmosphere, for the first time for a star other than the Sun. The images reconstructed with a spatial resolution of 6.8 mas—seven times finer than the star’s angular diameter of 51.2 mas in the continuum—using the AMBER instrument at the Very Large Telescope Interferometer show a large, bright region over the surface of the star and an extended atmosphere. The velocity-field maps over the star’s surface and atmosphere obtained from the Mg and H2O lines near 2.3 μm forming at atmospheric heights below ∼1.5 R
⋆ show little systematic motion beyond the measurement uncertainty of 1.7 km s−1. In marked contrast, the velocity-field map obtained from the CO first overtone lines reveals systematic outward motion at 7–15 km s−1 in the extended outer atmosphere at a height of ∼1.8 R
⋆. Given the detection of dust formation at ∼1.5 R
⋆, the strong acceleration of material between ∼1.5 and 1.8 R
⋆ may be caused by the radiation pressure on dust grains. However, we cannot yet exclude the possibility that the outward motion may be intermittent, caused by ballistic motion due to convection and/or pulsation.