bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication adherence and quality of life among geriatric patients: Insights from a hospital-based cross-sectional study in India
Authors: Khaiser Umaima Farheen , Sultana Rokeya , Das Ranajit , Alzahrani Saeed G. , Saquib Shahabe , Shamsuddin Shaheen , Fareed Mohammad 
Published: November 2024

Background
Understanding the factors that influence medication adherence and the multidimensional aspects of quality of life in the elderly is of paramount importance in enhancing their overall well-being. Since geriatric patients usually suffer from multiple morbidities due to their declining age, the adherence towards their medications plays a very crucial role in their quality of life.

Methodology
This cross-sectional study explores the intricate relationship between medication adherence and quality of life among 310 elderly patients at a single medical college and hospital. Participants completed the Morisky Medication Adherence Scale (MMAS-8) to assess medication adherence and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire, which comprises four domains (physical health, psychological health, social relationships, and environment) to evaluate quality of life. Statistical analyses, including correlations, paired t-tests, ANOVA, and Backward Multiple Linear Regression, were employed to examine the relationships and differences among variables.

Results
The findings indicate varying levels of medication adherence among participants, with a significant proportion exhibiting medium adherence (47.1%) and highlighting the need for interventions to address challenges in medication adherence among the elderly population. Notably, gender emerged as a significant factor influencing quality of life, with males reporting higher satisfaction across all domains compared to females. Medication adherence exhibited a significant correlation with the social relationships domain (DOM3) of the WHOQOL-BREF, underlining the importance of adherence in fostering positive social interactions.

Conclusion
Our study revealed a significant association between medication adherence (MMAS- 8) and the quality of life (WHOQOL-BREF) among elderly patients. We also observed noteworthy gender differences in quality-of-life perceptions. It emphasizes the need for tailored interventions that consider medication adherence issues to enhance the overall quality of life among this vulnerable population.
Budget impact analysis of subcutaneous infliximab (CT-P13 SC) for treating inflammatory bowel disease in Saudi Arabia: Analysis from payer perspective
Authors: Alkhatib Nimer S. , Almutairi Abdulaali R. , Almadi Majid , Halloush Shiraz , Al-Ruthia Yazed Sulaiman H. , Rashdan Omar , Al-Shatnawi Samah , Azzam Nahla A. , Mosli Mahmoud H. , Badawoud Amal M. , Al Yami Majed S. , Alhossan Abdulaziz , AlHarbi Ibtisam 
Published: November 2024

Background
The Saudi Food and Drug Authority (SFDA) has approved the subcutaneous (SC) administration of infliximab, presenting a more convenient alternative with reduced outpatient visits and diminished expenses compared to the intravenous (IV) administration. However, the financial implications of this formulation have not been examined from the perspective of Saudi payers.

Methods and materials
A prevalence-based budget impact model was developed to evaluate the financial effects of introducing "environment without" versus "with infliximab SC." The model’s time horizon spanned over 2 years (2021–2023), aligning with the biennial national pharmaceutical procurement cycle. The comparison focused on infliximab SC versus all available formulations of infliximab IV in the Saudi market for two inflammatory bowel diseases (IBD): Ulcerative Colitis (UC) and Crohn’s Disease (CD). Treatment comparators’ comparability and dose escalations were substantiated by published studies, utilizing dosing information from the summary of product characteristics. Drug acquisition costs were derived from SFDA registered prices, with IV formulation administration costs included. Scenario analysis assessed the budget impact of infliximab SC introduction at uptake rates ranging from 0% to 100%.

Results
Introducing infliximab SC demonstrated cost-saving potential in the treatment of IBD. At 100% uptake with UC patients for 2 years, infliximab SC resulted in savings of -SAR-31.9 million (-SAR29,145 per patient). Similarly, for CD, introducing infliximab SC at 100% uptake over 2 years yielded savings of -SAR106.2 million (-SAR36,585 per patient).

Conclusion
This study reveals that infliximab SC is associated with cost-saving potential when compared to infliximab IV formulations available in Saudi Arabia. Future research should address uncertainties related to real-world comparative effectiveness, the convenience of administration, patient tolerability, and physician acceptance of the SC formulation of infliximab, alongside comparisons with other TNF-alpha inhibitors.
Mapping the prevalence and covariates associated with home delivery in Bangladesh: A multilevel regression analysis
Authors: Dey Rakhi , Dey Susmita Rani , Haque Meem , Rahman Anushuya Binta , Kundu Satyajit , Setu Sarmistha Paul , Majumder U. K. 
Published: November 2024

Introduction
Bangladesh has made an intense effort to improve maternal healthcare facilities including facility delivery, but the number of home deliveries is still very high. Therefore, this study aims to find out district-wise prevalence and determine the individual and community-level predictors of home delivery among women in Bangladesh.

Methods
Data were derived from the Multiple Indicator Cluster Survey (MICS) 2019, a nationwide cross-sectional survey in Bangladesh. A final sample of 9,166 (weighted) women who gave birth in the two years preceding the survey were included in this study. Considering the two-stage cluster sampling strategy adopted by MICS, we used multilevel (2-level) logistic regression analysis to find out the correlates of home delivery.

Results
The overall weighted prevalence of home delivery was 46.41% (95% confidence interval [CI]: 45.39–47.43). The highest prevalence was observed in Bandarban district (84.58%), while the lowest was found in Meherpur district (6.95%). The intercept-only regression model demonstrates that the likelihood of women from various clusters having home delivery varied significantly (variance: 1.47, standard error [SE]: 0.117), indicating the applicability of multilevel regression modeling. The multilevel regression analysis showed that women with higher education, wealth status and ANC visit, and those aged >18 years at first marriage/union were associated with lower odds of delivering child at home compared to their counterparts. While women from age group of 35–49 years, whose last pregnancy was unintended were more likely to deliver child at home. In addition, those respondents belonging to a community that had higher wealth status, women’s education level, and exposure to media showed lower odds of having delivery at home.

Conclusions
The finding indicates that delivery at home is still high in Bangladesh. Targeted interventions to reduce home delivery are urgently needed in Bangladesh to tackle adversities during deliveries and save mothers from the consequences.
Effect of Esophageal Dilation History on Efficacy Outcomes in Patients With Eosinophilic Esophagitis Receiving Budesonide Oral Suspension
Authors: Hirano Ikuo , Collins Margaret H. , Katzka David A. , Mukkada Vincent A. , Falk Gary W. , Terreri Brian , Boules Mena , Zhang Wenwen , Desai Nirav K. , Dellon Evan S. 
Published: November 2024

INTRODUCTION:
The effect of esophageal dilation history on efficacy outcomes in patients with eosinophilic esophagitis (EoE) receiving swallowed corticosteroids is not well established.

METHODS:
This post hoc analysis assessed data from a 12-week, randomized, double-blind, placebo-controlled phase 3 study (NCT02605837) of budesonide oral suspension (BOS) 2.0 mg twice daily in patients aged 11–55 years with EoE and dysphagia. Coprimary efficacy outcomes were histologic (≤ 6 eosinophils per high-power field [eos/hpf]) and dysphagia symptom (≥ 30% reduction in Dysphagia Symptom Questionnaire scores from baseline) responses at week 12. Secondary efficacy outcomes included histologic response (< 15 eos/hpf) and change from baseline to week 12 in Dysphagia Symptom Questionnaire scores and EoE Endoscopic Reference Scores. Data were analyzed post hoc by esophageal dilation history (dilation history vs no dilation history).

RESULTS:
Of 318 patients who received ≥ 1 dose of study drug, 42.8% had a history of esophageal dilation (dilation history: BOS, n = 91; placebo, n = 45; no dilation history: BOS, n = 122; placebo, n = 60). Histologic responses (≤ 6 and < 15 eos/hpf) were similar regardless of dilation history. Fewer BOS-treated patients with dilation history than no dilation history achieved a dysphagia symptom response (44.0% vs 59.0%); conversely, a slightly greater improvement from baseline in total EoE Endoscopic Reference Scores was observed for BOS-treated patients with dilation history than no dilation history (least-squares mean [SE of the mean]: −4.1 [0.3] vs −3.4 [0.4]).

DISCUSSION:
Esophageal dilation history may confound the association between histologic outcomes and dysphagia symptom or endoscopic efficacy outcomes in patients with EoE receiving swallowed corticosteroids.
Perempuan dan Pendidikan Islam dalam Novel "'Asrul Al-Hub"
Authors: Sulthon Pamungkas  , Aning Ayu Kusumawati  
Published: November 2024

Abstrak
Penelitian ini fokus pada bagaimana peran perempuan dalam pendidikan Islam pada novel ’Aṣrul Al-Ḥub karya Najib Mahfuz. Hal yang menjadi titik berat artikel ini bahwa diperlukan pengamatan khusus terkait peran perempuan dalam pendidikan Islam, karena seperti digambarkan dalam Novel ’Aṣrul Al-Ḥub, peran perempuan sangat dominan dan konsisten dalam pendidikan Islam. Metode pengumpulan data dalam penelitian ini menggunakan metode simak dan catat dengan mencermati data primer berupa dialog yang ada dalam novel ’Aṣrul Al-Ḥub karya Najib Mahfuz tentang bagaimana pendidikan Islam disampaikan oleh tokoh-tokoh perempuan. Penelitian ini menunjukkan bahwa tokoh perempuan, yaitu ibu Izzat (Sitta ‘Ain) dan Sayyidah, secara konsisten mengajarkan pendidikan Islam melalui tiga strategi yaitu pemahaman, pembiasaan dan keteladanan. Sedang tiap kategori tersebut terdapat metode-metode pendidikan, misalnya pada kategori pemahaman terdapat metode diskusi, metode ‘Ibrah dan Maū’iẓah, metode penanaman motivasi, dan metode demontrasi. Sedang pada kategori pembiasaan terdapat metode kepekaan sosial dan tidak dendam/pemaaf, selanjutnya pada keteladanan terdapat optimisme dan konsistensi/kesabaran.
Kata Kunci: Perempuan, Pendidikan Islam, ’Aṣrul Al-Ḥub.
[This research focuses on the method of delivering Islamic education in the novel 'Aṣrul Al-Ḥub by Najib Mahfuz. The point of this article is that special observation is needed regarding the role of women in Islamic education, bearing in mind that in the Novel 'Aṣrul Al-Ḥub, women dominate and are consistent in teaching Islamic education. The data collection method in this study uses the observing and note-taking method to collect primary data in the form of dialogue in the novel 'Aṣrul Al-Ḥub by Najib Mahfuz which contains information about how Islamic education conveyed by female characters. This research shows that female figures, namely Sitta 'Ain and her daughter in law Sayyidah, consistently teach Islamic education through three categories, namely understanding, habituation and modelling. In each of these categories there are educational methods, for example in the understanding category there are discussion methods: 'Ibrah and Maū'iẓah, instilling motivation, and demonstration . While in the habituation category there are ways: social sensitivity and forgiveness, then in modelling there are optimism and consistency/patience.]
Keyword: Women, Islamic Education, 'Aṣrul Al-Ḥub.
From Flowers to Plants: Plant-Thinking in Nineteenth-Century Danish Flower Painting
Authors: Hedin Gry 
Published: November 2024

Abstract
In the nineteenth century, flower painters in Denmark shifted from depicting arranged, cut flowers to showing plants within their ecosystems. This article explores this shift by examining four paintings by the artists Christine Løvmand and Anthonore Christensen. According to Michael Marder and Emanuele Coccia, important philosophers in critical plant studies, plants have been overlooked as world creators. Coccia highlights the nineteenth century as a particularly low point, in this regard, but seeks exceptions and points to significant nineteenth-century articulations of how plants move in, sense, and create their environment. An investigation of Danish art and botany reveals similar articulations, as several significant artists made growing rather than cut plants the theme of some of their paintings and botanists explored the wild flora and the agency of plants. This nineteenth-century shift in focus from flowers to plants disseminates notions of plants that can inspire and help us reorient our relationship with the natural world.
Design and performance evaluation of a hybrid FSO-FTTx communication link utilizing UD-WDMA 1.28 Tbps data rates transmission under various weather conditions
Authors: Forsido Ashenafi Paulos , Gelmecha Demissie Jobir , Singh Ram Sewak 
Published: November 2024

Abstract
The rapid growth of high-data-rate applications necessitates the development of new communication frameworks since bandwidth constraints for data-intensive applications hinder traditional networks and conventional microwave/radio frequency (RF) communications. This study explores a hybrid communication link that combines fiber-to-the-x (FTTx) and free-space optical (FSO) technologies, utilizing ultra-dense wavelength-division multiple access (UD-WDMA) with a channel spacing of 0.2 nm/25 GHz, under various weather conditions. Based on bit error rate (BER), optical signal-to-noise ratio (OSNR), and quality factor (QF), the performance of the suggested FSO-FTTx system was examined. The system performed well in diverse weather conditions, achieving a minimum BER of ≤10−5, QF values of 4 or higher, and OSNR levels between 10 and 20 dB. The proposed system successfully transmitted a data rate of 1.28 Tbps over 35 km in single-mode fiber (SMF), accommodating different FSO link ranges despite varying weather conditions. However, performance fluctuations were observed under adverse conditions, with attenuation ranging from 0.91 dB/km in extremely light mist to 273.39 dB/km in dense fog, impacting the FSO link range. The findings underscore the proposed hybrid system’s potential to enhance optical wireless communication for high data rates, making it promising for beyond 5G and early 6G applications.
Exact solutions of a class of generalized nanofluidic models
Authors: Zeng Huajun , Ming Yuduo , Jiang Tao , Jin Cheng 
Published: November 2024

Abstract
Nanofluid, a significant branch of fluid mechanics, plays a pivotal role in thermal management, optics, biomedical engineering, energy harvesting, and other fields. The nanoparticles present in the fluid render the continuum mechanics ineffective, necessitating the adoption of fractional calculus to elucidate the effects of nanoparticles on the motion properties of the nanofluid. This article applies the modified extended tanh-function technique to solve two classical Schrödinger equations, the fractional Phi-4 model and the conformable fractional Boussinesq model, for nanofluids. Multiple exact solutions are obtained, and the corresponding graphical representations are provided to elucidate the basic properties of the nanofluid. This article provides new research perspectives for the development of nanofluids.
Perceived threats to the future of Icelandic and the importance of language acquisition research
Authors: Nowenstein Iris , Sigurjónsdóttir Sigríður 
Published: November 2024

Abstract
Rising public concern regarding the linguistic effects of an increased, digitally mediated English presence in Iceland was one of the factors motivating the research project Modeling the Linguistic Consequences of Digital Language Contact (MoLiCoDiLaCo), in 2016–2019. In public discourse, a causal relationship between digital English input and reduced/incompletely acquired Icelandic had been (and still is) assumed, without scientific evidence. While the MoLiCoDiLaCo project sought to provide evidence for this assumption, the results did not show extensive English input effects on Icelandic linguistic variables. The main results of the project are discussed in the article with reference to a recent shift in the public narrative of perceived threats to the future of Icelandic. The authors show that the focus has in part moved away from digital language contact between English and Icelandic, and toward the rise of English as a lingua franca in the interactions of L1 and L2 speakers of Icelandic. This shift is discussed in terms of recent research on language acquisition, multilingualism, linguistic gatekeeping, and the preservation of globally small languages.
The Cicero-Appius reconciliation and Pompey’s pivotal role as mediator
Authors: Evangelou Gabriel 
Published: November 2024

Abstract
The intricacies of the relationships between Roman aristocrats in the age of Cicero has been one of the most popular topics of discussion in modern scholarship. Cicero’s letters have drawn considerable attention as an invaluable source for the study of amicitiae in the late Roman republic. Nevertheless, the methods that Cicero and his contemporaries used to reconcile with their former enemies is an area that remains rather unexplored. This paper aims to shed light on the significance of letter writing as a medium for the reconciliation between Romans with an active public life and to underscore the role that mediators played in the conciliatory efforts that both parties made to restore their relationship chiefly in the public eye. The investigation focuses on Cicero’s well-attested reconciliation with Appius Claudius Pulcher. It argues that, while it was not the first instance in which Pompey instigated a reconciliation between two of his allies, its uniqueness lies in the ingenious and complex use of letter writing to effect and maintain their renewed relationship as well as in the combination of frankness and tactful manoeuvring in Cicero’s letters to him.
Narratives of reconciliation in Caesar’s
Commentarii
Authors: Grillo Luca 
Published: November 2024

Abstract
Romans appreciated reconciliation and even celebrated and advertised it by dedicating temples and coins to Concordia. Accordingly, Caesar’s Commentarii value reconciliation as well. Indeed, I will argue that, in spite of the war-bulletin tone that often pervades the Commentarii, reconciliation plays a key-role in Caesar’s accounts both of the Gallic and of the Civil War. In particular, in the first part of my paper I consider some narrative strategies whereby Caesar advertises his openness toward reconciliation in BG. Caesar’s self-fashioning in his dealings with Dumnorix and Ariovistus in BG 1 exemplifies a typical script: Caesar (says he) is willing to extend his gratia, but some enemies refuse it, and Caesar’s biased narrative presents such refusal as highly unreasonable; but their stubbornness voids any attempt at reconciliation, and war ensues. Other episodes from the BG confirm this pattern. In part two, through an analysis of the siege at Brundisium (BC 1.26) and of the blockade at Oricum (3.15), I suggest that, in the BC, Caesar follows the same script as in the BG; but the BC presents a more rich and technical vocabulary of reconciliation along with some exceptional narratological devices. I try to show how the artful narrator sharpens his tools to deal with the thorny topic of reconciliation in a civil war. In the third and last part of my paper, I place Caesar’s representation against two contemporary letters found in Cicero’s correspondence with Atticus; briefly, I consider some contemporary responses to Caesar’s narratives of reconciliation.
Reconciliation and Civil War in Plutarch’s
Life of Pompey
Authors: Cau Francesca 
Published: November 2024

Abstract
Reconciliation is a central theme in Plutarch’s political reflections, prominently discussed in his treatise Praecepta gerendae reipublicae. In this work, Plutarch criticizes the competitive nature of the aristocrats of his own time, which often led to factional conflicts (στάσεις) necessitating Roman intervention. Thus, he advocates for reconciliation as a proactive strategy to prevent warfare and maintain state harmony (ὁμόνοια).
These considerations are crucial for interpreting certain passages in the Life of Pompey, where Plutarch reflects in depth on the dynamics that led to the Civil War of 49 BCE. In this biography, Pompey is criticized for rejecting Caesar’s proposals for reconciliation, viewing this refusal as the direct cause of the civil war’s outbreak. However, the deeper reason for the conflict is identified in the rivalry among Pompey, Caesar, and Crassus, which had been skilfully masked by their apparent friendship, achieved in part through the reconciliation between Pompey and Crassus. The Life of Pompey thus adds a layer of complexity to the explicit lessons of the Praecepta; nevertheless, it does not contradict them, since Plutarch’s ultimate concern, both in the Moralia and the Lives, is the preservation of concord within the state.
Expression levels of some genes in the MAPK pathway (DUSP1, DUSP2, DUSP4, DUSP6 and DUSP10) in eyelid tumor tissue
Authors: Ozmen Esma , Tas Ayca , Akin Dilara Fatma , Erdogan Haydar , Silig Yavuz 
Published: November 2024

Abstract

Objectives
To control mitogen-activated protein kinases (MAPK) signaling pathways involved in the onset and progression of cancer, dual specificity phosphatases (DUSPs/MKP) are essential. This study seeks to detect the correlation between eyelid tumors and the genes DUSPs, known for their influence on MAPK signaling pathways. Additionally, we aim to juxtapose our findings with analyses from various bioinformatics databases.

Methods
Expression levels of relevant genes in cDNA samples were determined by quantitative PCR method. Open-access databases were used for mutation analysis of relevant genes, mRNA expression changes, and survival analyses, and the STRING database was used for protein-protein interactions.

Results
It was found that the expression of DUSP1 and DUSP2 showed a significant decrease in the tumor tissue, while a significant increase was detected in the DUSP4 and DUSP6 genes. Additionally, when we compared the study genes with the Cancer Genome Atlas program cancer cohorts, it was found that the DUSP1 and DUSP10 gene expression profiles were downregulated in uveal melanoma compared to other cancer cohorts.

Conclusions
Significant and obvious changes were observed in the DUSP genes we studied in eyelid tumors. However, the relationship between these genes and cancer must be studied more. Considering that these enzymes are effective in cell proliferation, differentiation, and apoptosis, it would be appropriate to plan comprehensive studies on their interactions with other proteins they interact with in the MAPK pathway.