bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of human skin bacteria attractive to the Asian Tiger mosquito
Authors: Michalet Serge , Minard Guillaume , Chevalier Wilfried , Meiffren Guillaume , Saucereau Yoann , Tran Van Van , Comte Gilles , Tran Florence‐Hélène , Valiente Moro Claire 
Published: August 2019

SummaryAedes albopictusis a vector of arboviruses and filarial nematodes. Originating from Asia, this mosquito has rapidly expanded its geographical distribution and colonized areas across both temperate and tropical regions. Due to the increase in insecticide resistance, the use of environmentally friendly vector control methods is encouraged worldwide. Using methods based on semiochemicals in baited traps are promising for management of mosquito populations. Interestingly, human skin microbiota was shown to generate volatile compounds that attract the mosquito speciesAnopheles gambiaeandAedes aegypti. Here, we investigated the composition of skin bacteria from different volunteers and the attractive potential of individual isolates to nulliparousAe.albopictusfemales. We showed that three out of 16 tested isolates were more attractive and two were more repulsive. We identified dodecenol as being preferentially produced by attractive isolates and 2‐methyl‐1‐butanol (and to a lesser extent 3‐methyl‐1‐butanol) as being overproduced by these isolates compared with the other ones. Those bacterial volatile organic compounds represent promising candidates but further studies are needed to evaluate their potential application for baited traps improvement.
The association between reproductive factors and systemic sclerosis in Chinese women: A case‐control study and meta‐analysis
Authors: Li Juan , Chen Shan‐Yu , Yin Xiao‐Dong , Cao Long‐Ting , Huang Xiao‐Lei , Xu Jian‐Hua , Ye Dong‐Qing , Wang Jing 
Published: August 2019

AbstractAimTo examine the associations between female menstrual or reproductive factors and the development of systemic sclerosis (SSc) in China.MethodsIn this hospital‐based case‐control study, for each subject, data on reproductive and menstrual factors such as number of births, abortions, and age at menarche were obtained by structured questionnaire. Risk estimates, measured by the odds ratio (OR) and 95% confidence interval (CI), were obtained by unconditional logistics regression. Furthermore, meta‐analysis was performed and pooled OR with 95% CI for the number of pregnancies and abortions were calculated.ResultsThere were 166 SSc and 392 female controls seen during the study period. The results showed women with late menarche age (≥17 years) were less likely than those with earlier age at menarche to develop SSc (OR 0.347, 95% CI 0.174‐0.693) and compared with women without abortion, women with abortion (1 time) were at reduced risk of developing SSc (P = .036). After adjusting for potential confounders such as occupation and body mass index (BMI), late age at menarche (≥17 years) was associated with a decreased risk of SSc (OR 0.187, 95% CI 0.068‐0.513), but abortions were not significantly related to SSc. The meta‐analysis revealed there was no association between SSc and abortions or number of pregnancies. No significant publication bias was observed (P > .05).ConclusionLate age at menarche was associated with a reduced risk of SSc but abortion may not be an independent risk factor for SSc. Further investigations are required to verify our findings.
Clinical examination findings as predictors of acute kidney injury in critically ill patients
Authors: Wiersema Renske , Koeze Jacqueline , Eck Ruben J. , Kaufmann Thomas , Hiemstra Bart , Koster Geert , Franssen Casper F. M. , Vaara Suvi T. , Keus Frederik , Van der Horst Iwan C. C. 
Published: August 2019

BackgroundAcute Kidney Injury (AKI) in critically ill patients is associated with a markedly increased morbidity and mortality. The aim of this study was to establish the predictive value of clinical examination for AKI in critically ill patients.MethodsThis was a sub‐study of the SICS‐I, a prospective observational cohort study of critically ill patients acutely admitted to the Intensive Care Unit (ICU). Clinical examination was performed within 24 hours of ICU admission. The occurrence of AKI was determined at day two and three after admission according to the KDIGO definition including serum creatinine and urine output. Multivariable regression modeling was used to assess the value of clinical examination for predicting AKI, adjusted for age, comorbidities and the use of vasopressors.ResultsA total of 1003 of 1075 SICS‐I patients (93%) were included in this sub‐study. 414 of 1003 patients (41%) fulfilled the criteria for AKI. Increased heart rate (OR 1.12 per 10 beats per minute increase, 98.5% CI 1.04‐1.22), subjectively cold extremities (OR 1.52, 98.5% CI 1.07‐2.16) and a prolonged capillary refill time on the sternum (OR 1.89, 98.5% CI 1.01‐3.55) were associated with AKI. This multivariable analysis yielded an area under the receiver‐operating curve (AUROC) of 0.70 (98.5% CI 0.66‐0.74). The model performed better when lactate was included (AUROC of 0.72, 95%CI 0.69‐0.75), P = .04.ConclusionClinical examination findings were able to predict AKI with moderate accuracy in a large cohort of critically ill patients. Findings of clinical examination on ICU admission may trigger further efforts to help predict developing AKI.
Does Shared Decision Making Actually Occur in the Emergency Department? Looking at It from the Patients’ Perspective
Authors: Schoenfeld Elizabeth M. , Probst Marc A. , Quigley Denise D. , St. Marie Peter , Nayyar Nikita , Sabbagh Sarah H. , Beckford Tanesha , Kanzaria Hemal K. 
Published: August 2019

AbstractObjectiveWe sought to assess the frequency, content, and quality of shared decision making (SDM) in the emergency department (ED), from patients’ perspectives.MethodsUtilizing a cross‐sectional, multisite approach, we administered an instrument, consisting of two validated SDM assessment tools—the CollaboRATE and the SDM‐Q‐9—and one newly developed tool to a sample of ED patients. Our primary outcome was the occurrence of SDM in the clinical encounter, as defined by participants giving “top‐box” scores on the CollaboRATE measure, and the ability of patients to identify the topic of their SDM conversation. Secondary outcomes included the content of the SDM conversations, as judged by patients, and whether patients were able to complete each of the two validated scales included in the instrument.ResultsAfter exclusions, 285 participants from two sites completed the composite instrument. Just under half identified as female (47%) or as white (47%). Roughly half gave top‐box scores (i.e., indicating optimal SDM) on the CollaboRATE scale (49%). Less than half of the participants were able to indicate a decision they were involved in (44%), although those who did gave high scores for such conversations (73/100 via the SDM‐Q‐9 tool). The most frequently identified decisions discussed were admission versus discharge (19%), medication options (17%), and options for follow‐up care (15%).ConclusionsFewer than half of ED patients surveyed reported they were involved in SDM. The most common decision for which SDM was used was around ED disposition (admission vs. discharge). When SDM was employed, patients generally rated the discussion highly.
The unintended consequences of voluntary adoption of clawback provisions on managerial ability
Authors: El Mahdy Dina 
Published: August 2019

AbstractI investigate the impact of the voluntary adoption of clawback provisions on managerial ability and predict that clawback provisions will motivate managers to exert more efforts following the adoption of clawback and these efforts will be in the form of an increased managerial efficiency. Using a propensity score matched sample of firms, I find a significant positive association between voluntary clawback adoption and the change in both rank and score of managerial ability. My study highlights the unintended consequences of clawback provisions on CEO's behavior and contributes to the on‐going debate on the importance of proactively and carefully drafting clawback policies, further signifying the importance of the SEC's efforts (Rule 10D‐1) to enforce clawback policies.
Seeing is important: the usefulness of video information in P2P
Authors: Wang Huijuan , Yu Mengxia , Zhang Lu 
Published: August 2019

AbstractP2P lending is an important research subject of rising internet finance research. This paper uses unique data from Renrendai, a leading platform in China, to test the influence of video information on P2P lending behavior. Results suggest that, first, the lower the borrower's credit rating is, the more likely they are to provide video information. Second, compared to the video‐information‐absent borrowers, the otherwise borrowers can get easier access to a loan and offer a lower interest rate. These results indicate that compared to text messages, video information can increase the borrower's creditworthiness and reduce the transaction risk. Thereupon seeing is important in online P2P lending. Third, when the borrower's credit rating is lower, the video effect is significant. The study makes sense in terms of the enrichment of P2P lending literature and the enlightenment on decision‐making of both lenders and borrowers.
Embedding environment and sustainability into corporate financial decision‐making
Authors: Siegrist Manuel , Bowman Gary , Mervine Evelyn , Southam Colette 
Published: August 2019

AbstractThe business case for sustainability can be built upon: (i) cost reduction from efficient resource utilisation, (ii) revenue enhancement, (iii) risk management, and (iv) intangible assets. However, executives often adopt a short‐term perspective owing to executive compensation, investor pressure, and decision‐making criteria tied to fixed financial reporting systems. We propose an integrated conceptual framework, which highlights how firms could embed environment and sustainability into their long‐term financial decision‐making framework. To give this goal structure, the firm could adopt: (i) longer‐term executive compensation plans, (ii) longer‐term financial reporting, and (iii) flexible financial decision‐making models which embed intangibles.
A new micropterous, ground‐dwelling, non‐cyclostome braconid parasitoid wasp, Epigeiobracon perplexus Quicke & Ward, gen. et sp. nov. (Hymenoptera: Braconidae) from New Zealand of uncertain relationships
Authors: Quicke Donald L J , Ward Darren F , Butcher Buntika A 
Published: August 2019

AbstractA morphologically highly derived, litter‐dwelling, apterous, non‐cyclostome braconid wasp from New Zealand is described and illustrated as Epigeiobracon perplexus Quicke & Ward, gen. et sp. nov. The subfamilial placement of the new taxon based on morphology seems impossible though a protruding face, well‐developed round pronope and presence of a few apical pegs on the hind tibia are suggestive of Orgilinae, but we cannot completely rule out the small subfamily Microtypinae with which the new genus shares an extremely reduced third segment of the labial palp.
Australian millipede assassins (Heteroptera: Reduviidae): Malingeus tumidus gen. et sp. nov. and Yaramayahus rufescens gen. et sp. nov., with new generic synonyms and an updated key
Authors: Swanson Daniel R 
Published: August 2019

AbstractMalingeus tumidus gen. et sp. nov., a new millipede assassin from Queensland, and Yaramayahus rufescens gen. et sp. nov., a new millipede assassin from New South Wales, are herein described from the tribe Ectrichodiini (Ectrichodiinae). Additionally, Caloundranius formosus Miller, 1957, syn. nov. is here considered a junior synonym of Mendola puellula Breddin, 1900, which relegates the genus Caloundranius Miller, 1957, syn. nov. to a junior synonym of Mendola Breddin, 1900. The previously proposed status of Tasmanocoris evansi Miller, 1952, as a junior synonym of Nebriscus pupus Bergroth, 1895, is corroborated. Brisbanocoris fuscipennis Miller, 1957, syn. nov. is here considered a junior synonym of Lyramna vigil Breddin, 1900, which relegates the genus Brisbanocoris Miller, 1957, syn. nov. to a junior synonym of Lyramna Breddin, 1900. Finally, an updated generic key to the ectrichodiine genera of Australia is presented.
Description and novel host records for a new species of Australian mutillid wasp (Hymenoptera: Mutillidae) from hylaeine bee nests (Hymenoptera: Colletidae)
Authors: Hearn Lucas R , Williams Kevin A , Stevens Mark I , Schwarz Michael P , Davies Olivia K , Parslow Ben A 
Published: August 2019

AbstractA new mutillid wasp, Ephutomorpha tyla Hearn, Williams & Parslow sp. nov., is described from adult female and male specimens from the Dandenong Ranges in Victoria, Australia. Adult mutillids were repeatedly found in nests of the hylaeine bee Amphylaeus morosus (Smith, 1879) (Hylaeinae) and reared from host nest cells. This represents the first recorded host–parasite association between Mutillidae and hylaeine bee species.
Three new species of the New Zealand endemic, Neptihormius van Achterberg & Berry (Hymenoptera: Braconidae), with diverse host records
Authors: Quicke Donald L J , van Achterberg Kees , Ward Darren , Butcher Buntika A 
Published: August 2019

AbstractThree new species of the New Zealand endemic braconid genus Neptihormius van Achterberg & Berry (Mesostoinae) are described. One of these species was reared from dipteran hosts on Coprosma (Rubiaceae): N. dipterophagus Quicke, Ward & van Achterberg sp. nov. from an agromyzid and unidentified gall‐forming cecidomyiid hosts. Neptihormius whakapapa Quicke & Ward sp. nov. was reared from a gall, thought to have been caused by a curculionid beetle. The third new species, N. herbaspicatum Quicke & Ward sp. nov., was reared from the New Zealand endemic moth Glyphipterix iocheaera Meyrick, 1880. A key to the species of Neptihormius is provided. Host records show Neptihormius attack galls and concealed leaf‐miner hosts indicating evolutionary plasticity in host utilisation.
Workspace environmental design evaluation to support the aged care workforce: Are we using the right evaluation approaches?
Authors: Naccarella Lucio , Newton Clare , Dow Briony , Beckman Nikki 
Published: August 2019

AbstractObjectivesAustralia's aged care workforce is facing pressures due to increased demands from an ageing population. This paper reflects upon whether existing workspace environmental design evaluations are supporting the aged care workforce.MethodsThis brief report was informed by a 2018 Optimising Aged Care Workspace Environment Symposium with three streams: (a) Developing, (b) Implementing and (c) Evaluating Aged Care Workspace Environments.ResultsSymposium key messages included the following: 'evidence (lived experiences and feedback) from both older people and the aged care workforce needs to inform both development and implementation of aged care environment design'. The Evaluating Aged Care Workspace Environments stream key messages included the following: 'evaluation approaches are required that are responsive and appropriate to the complex dynamic aged care workspace contexts'.ConclusionTo better inform the design of future aged care settings and support the aged care workforce, principles‐focused evaluations of existing aged care settings with input from the aged care workforce are required.
Do Indigenous patients in Australia's Northern Territory present with more advanced colorectal cancer? A cohort study based on registry data
Authors: Read David J. , Hayes Ian 
Published: August 2019

BackgroundPrevious studies show that Indigenous Australians (IndA) of the Northern Territory (NT) present later and have lower survival for colorectal cancer (CRC) compared with non‐Indigenous (NI) Territorians. This study compared the odds of presenting with advanced‐stage CRC between IndA and NI adjusted for demographic, histopathological and surgical features.MethodsA cohort study of NT Cancer Registry (NTCR) CRC cases from 2005 to 2014. All (667) persons notified to the NTCR with a new diagnosis of CRC were included, of which 504 had sufficient data for analysis. The NTCR was used for case identification and linked to available hospital clinical data. The principal exposure was IndA compared with NI and the principal outcome was odds of presenting with advanced‐stage tumour (III and IV) compared with early‐stage (I and II). Univariable and multivariable logistic regression were performed on all relevant variables.ResultsUnivariable logistic regression found no difference in the odds of advanced CRC between IndA and NI (odds ratio (OR) 0.99, 95% confidence interval (CI) 0.56–1.76, P = 0.982). This effect remained insignificant adjusted for the effects of sex, tumour position, remoteness and time period (OR 0.85, 95% CI 0.47–1.55, P = 0.606) and when adjusted for tumour grade, lympho‐vascular invasion, lymph node harvest and emergency status (OR 1.39, 95% CI 0.64–3.03, P = 0.401).ConclusionsIn distinction from previous studies, there was no evidence that IndA of the NT presented with later stage CRC in 2005–2014. Other factors (incomplete treatment or comorbidity) may be responsible for the continued observed survival disparity.
Muscarinic receptors in energy homeostasis: Physiology and pharmacology
Authors: Falk Sarah , Lund Camilla , Clemmensen Christoffer 
Published: August 2019

AbstractDespite increased awareness and intensified biomedical research efforts, the prevalence of obesity continues to rise worldwide. This is alarming, because obesity accelerates the progression of several chronic disorders, including type 2 diabetes, cancer and cardiovascular disease. Individuals who experience significant weight loss must combat powerful counter‐regulatory energy homeostatic processes, and, typically, most individuals regain the lost weight. Therefore, decoding the neural mechanisms underlying the regulation of energy homeostasis is necessary for developing breakthroughs in obesity management. It has been known for decades that cholinergic neurotransmission both directly and indirectly modulates energy homeostasis and metabolic health. Despite this insight, the molecular details underlying the modulation remain ill‐defined, and the potential for targeting cholinergic muscarinic receptors for treating metabolic disease is largely uncharted. In this MiniReview, we scrutinize the literature that has formed our knowledge of muscarinic acetylcholine receptors (mAChRs) in energy homeostasis. The role of mAChRs in canonical appetite‐regulating circuits will be discussed as will the more indirect regulation of energy homoeostasis via neurocircuits linked to motivated behaviours and emotional states. Finally, we discuss the therapeutic prospects of targeting mAChRs for the treatment of obesity and type 2 diabetes.
An ambiguity in Habermas’s argument against liberal eugenics
Authors: Schäfer Leon‐Philip 
Published: August 2019

AbstractIn his book The future of human nature, Jürgen Habermas argues against a scenario of liberal eugenics, in which parents are free to prenatally manipulate their children’s genetic constitution via germline interventions. In this paper, I draw attention to the fact that his species‐ethical line of argument is pervaded by a substantial ambiguity between an argument from actual intervention (AAI) and an argument from mere controllability (AMC). Whereas the first argument focuses on threats for the autonomy and equality of prenatally modified persons, the second argument takes all human beings, whether they have been modified or not, into account. Hence, when invoking Habermas in these debates, bioethicists need to consider carefully which argument they are referring to.
In situ BCL2 expression is an independent prognostic factor in HIV‐associated DLBCL, a LYMPHOVIR cohort study
Authors: Philippe Laure , Lancar Remi , Laurent Camille , Algarte‐Genin Michele , Chassagne‐Clément Catherine , Fabiani Bettina , Pierre Chenard Marie , Lazure Thierry , Parrens Marie , Charlotte Frederic , Delattre Claire , Gibault Laure , Capron Frederique , Goubin‐Versini Isabelle , Petitjean Bruno , Boué François , Mounier Nicolas , Costello Regis , Costagliola Dominique , Prevot Sophie , Besson Caroline ,   ANRS‐CO16 LYMPHOVIR Cohort
Published: August 2019

SummaryThe prognostic value of cell of origin (COO) classification and BCL2 expression is not well established in diffuse large B‐cell lymphoma (DLBCL) patients with human immunodeficiency virus (HIV) infection in the recent era. Phenotypic patterns were determined by immunohistochemistry (IHC) of pathological samples from patients with HIV‐associated DLBCL prospectively enrolled in the French AIDS and Viral Hepatitis CO16 Lymphovir cohort between 2008 and 2015. Molecular subgroup classification into germinal centre B‐cell (GCB) and non‐GCB subtypes was determined using the Hans algorithm. Among 52 samples of systemic DLBCL subjected to centralized pathological analysis, 25 of the 42 tested for BCL2 expression were positive. Samples were further classified into GCB (n = 19) and non‐GCB (n = 16) subtypes and 17 remained unclassified. In multivariable analysis, BCL2 expression was an independent pejorative prognostic biomarker [4‐year progression‐free survival (PFS): 52% for BCL2+ vs. 88% for BCL2−, P = 0·02] and tended to reduce 4‐year overall survival (OS) (63% for BCL2+ vs. 88% for BCL2−, P = 0·06). The difference between CGB and non‐GCB subtypes on PFS and OS did not reach significance (4‐year PFS: 79% for GCB vs. 53% for non‐GCB, P = 0·24 and 4‐year OS: 78% for GCB vs. 69% for non‐GCB, P = 0·34). BCL2 expression determined by IHC is an independent pejorative prognostic biomarker in HIV‐associated DLBCL in the recent era. This supports the investigation of new therapeutic strategies in patients with BCL2 expression.
Silencing of microRNA‐494 inhibits the neurotoxic Th1 shift via regulating HDAC2‐STAT4 cascade in ischaemic stroke
Authors: Zhao Haiping , Li Guangwen , Wang Rongliang , Tao Zhen , Ma Qingfeng , Zhang Sijia , Han Ziping , Yan Feng , Li Fangfang , Liu Ping , Ma Shubei , Ji Xunming , Luo Yumin 
Published: August 2019

Background and PurposeT helper cell 1 (Th1)‐skewed neurotoxicity contributes to the poor outcome of stroke in rodents. Here, we have elucidated the mechanism of the Th1/Th2 shift in acute ischaemic stroke (AIS) patients at hyperacute phase and have looked for a miRNA‐based therapeutic target.Experimental ApproachMiR‐494 levels in blood from AIS patients and controls were measured by real‐time PCR. C57BL/6J mice were subjected to transient middle cerebral artery occlusion, and cortical neurons were subjected to oxygen–glucose deprivation. Luciferase reporter system, chromatin immunoprecipitation sequencing (ChIP‐Seq), and ChIP‐PCR were used to uncover possible mechanisms.Key ResultsIn lymphocytes from AIS patients, there was a Th1/Th2 shift and histone deacetylase 2 (HDAC2) was markedly down‐regulated. ChIP‐seq showed that HDAC2 binding sites were enriched in regulation of Th1 cytokine production, and ChIP‐PCR confirmed that HDAC2 binding was changed at the intron of STAT4 and the promoter of T‐box transcription factor 21 (T‐bet) in lymphocytes from AIS patients. MiR‐494 was the most significantly increased miRNA in lymphocytes from AIS patients, and miR‐494‐3p directly targeted HDAC2. A strong association existed between miR‐494 and Th1 cytokines, and neurological deficit as measured by the National Institute of Health Stroke Scale (NIHSS) in AIS patients. In vitro and in vivo experiments showed that antagomir‐494 reduced Th1 shift‐mediated neuronal and sensorimotor functional damage in the mouse model of ischaemic stroke, via the HDAC2‐STAT4 pathway.Conclusion and ImplicationsWe demonstrated that miR‐494 inhibition prevented Th1‐skewed neurotoxicity through regulation of the HDAC2‐STAT4 cascade.