bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions in Civilian Nuclear Emergencies: An Operational Plan for Population and Injured Workers
Authors: Muzzi Armando , Strambi Ernesto , Trenta Giorgio 
Published: May 2019

AbstractThe authors describe Italian public health intervention planning for civil nuclear emergencies. With the exception of a few special aspects of prophylaxis and therapy, public health intervention in the case of nuclear emergencies are basically the same as those planned for “conventional emergencies,” however, a key role in nuclear emergencies could be played by the psychological aspect. Two different situations must be considered: 1) nuclear accidents involving workers only; and 2) nuclear accidents involving population as well. Differences in public health intervention required to address these two situations are discussed, both in terms of public health personnel involved, and of public health means and structures that should be available.
Psychometric properties of the Cognitive and Behavioural Responses Questionnaire (CBRQ) in adolescents with chronic fatigue syndrome
Authors: Loades M. E. , Vitoratou S. , Rimes K. A. , Ali S. , Chalder T. 
Published: May 2019

AbstractBackground:To better understand the maintenance of chronic fatigue syndrome (CFS), a valid and reliable measure of cognitive and behavioural responses to symptoms is required. Such a measure could also assess beliefs and coping behaviours in the context of fatigue in other somatic conditions.Aims:We aimed to establish the psychometric properties of both the Cognitive and Behavioural Responses Questionnaire (CBRQ) and its shortened version (CBRQ-S) in adolescents with CFS.Method:The full questionnaire was completed by a clinical cohort of adolescents (n= 121) presenting to specialist CFS units in the UK.Results:Both the CBRQ and CBRQ-S had good internal consistency. The CBRQ scores were strongly associated with depression, anxiety, school and social functioning, but weakly associated with fatigue and physical functioning, providing evidence of validity.Conclusion:Both the 40-item and the 18-item versions of the CBRQ were found to be reliable and valid in adolescents with CFS. To minimize unnecessary burden, the 18-item version is favoured. Using this assessment tool in future studies, including intervention studies, may help to better target interventions during clinical practice and improve outcomes.
Boundary Detection in Three Dimensions With Application to the SMILE Mission: The Effect of Photon Noise
Authors: Jorgensen Anders M. , Sun Tianran , Wang Chi , Dai Lei , Sembay Steven , Wei Fei , Guo Yihong , Xu Ronglan 
Published: May 2019

AbstractImaging magnetospheric satellite missions provide information, which is complementary to in situ observations. Imaging is often able to provide an instantaneous picture of large‐scale structures, whereas in situ measurements, even multipoint in situ measurements, can only provide an average view of large‐scale structure. But imaging also presents some challenges. When three‐dimensional structures need to be extracted from two‐dimensional images, it is necessary to either make suitable assumptions or record a large enough number of images from different viewing geometries to allow a reconstruction (e.g., tomography). Imaging data exist over a wide range of sources including visible light, ultraviolet light, extreme ultraviolet, energetic neutral atoms, and X‐rays, each informing different physical mechanisms. In this paper we consider the extraction of the geometry of the magnetopause and the bow shock from single X‐ray images expected from the Solar wind Magnetosphere Ionosphere Link Explorer (SMILE) mission. We examine the effect of photon‐counting noise in determining the boundary geometries. We also consider the effect of different viewing geometries in the form of orbital vantage point and target look direction. Finally, we consider the effect of background noise. We find that our approach is relatively robust to viewing geometry effects and works at low count rates.
Observing and Modeling Ice Sheet Surface Mass Balance
Authors: Lenaerts Jan T. M. , Medley Brooke , van den Broeke Michiel R. , Wouters Bert 
Published: May 2019

AbstractSurface mass balance (SMB) provides mass input to the surface of the Antarctic and Greenland Ice Sheets and therefore comprises an important control on ice sheet mass balance and resulting contribution to global sea level change. As ice sheet SMB varies highly across multiple scales of space (meters to hundreds of kilometers) and time (hourly to decadal), it is notoriously challenging to observe and represent in models. In addition, SMB consists of multiple components, all of which depend on complex interactions between the atmosphere and the snow/ice surface, large‐scale atmospheric circulation and ocean conditions, and ice sheet topography. In this review, we present the state‐of‐the‐art knowledge and recent advances in ice sheet SMB observations and models, highlight current shortcomings, and propose future directions. Novel observational methods allow mapping SMB across larger areas, longer time periods, and/or at very high (subdaily) temporal frequency. As a recent observational breakthrough, cosmic ray counters provide direct estimates of SMB, circumventing the need for accurate snow density observations upon which many other techniques rely. Regional atmospheric climate models have drastically improved their simulation of ice sheet SMB in the last decade, thanks to the inclusion or improved representation of essential processes (e.g., clouds, blowing snow, and snow albedo), and by enhancing horizontal resolution (5–30 km). Future modeling efforts are required in improving Earth system models to match regional atmospheric climate model performance in simulating ice sheet SMB, and in reinforcing the efforts in developing statistical and dynamic downscaling to represent smaller‐scale SMB processes.
Western Mediterranean Subcontinental Mantle Emplacement by Continental Margin Obduction
Authors: Gueydan Frédéric , Mazzotti Stephane , Tiberi Christel , Cavin Remy , Villaseñor Antonio 
Published: May 2019

AbstractObduction is the tectonic process that results from thrusting of an oceanic lithosphere section (ophiolite) onto a continent. In contrast, thrusting of subcontinental mantle, observed in several mountain belts, remains a major unknown of plate tectonics. In the western Mediterranean, the Ronda and Beni Bousera peridotites are the largest worldwide subcontinental mantle exposure. From a geological point of view, the Ronda peridotites are exhumed by hyperstretching of the continental lithosphere in a back‐arc immediately followed by thrusting, explaining their present‐day position inside the Alboran crust. Using 2‐D and 3‐D modeling of new gravimetric data combined with local seismic tomography, we show that the Ronda peridotites are rooted inside the Alboran mantle along the entire Gibraltar arc. On these bases, we propose that the emplacement of the Ronda peridotites occurred in a back‐arc setting and corresponds to the thrusting of an entire hyper‐stretched continental margin onto a continent, a process that we define as continental margin obduction. This results from two successive deformation events: continental upper plate extension driven by slab roll‐back, immediately followed by upper plate shortening, likely triggered when a buoyant continental domain enters the subduction. We propose that this process affected the entire western Alboran domain, with peridotite bodies embedded within the crust along the whole Gibraltar Arc. We suggest that other examples such as the Alps Ivrea mantle body could likely represent continental margin obduction at the onset of continental collision.
On the Influence of Upstream Flow Contributions on the Basin Response Function for Hydrograph Prediction
Authors: Bunster Tomás , Gironás Jorge , Niemann Jeffrey D. 
Published: May 2019

AbstractSpatially distributed travel time (SDTT) methods have been developed as an alternative to semidistributed and fully distributed methods for rainfall‐runoff modeling. In these methods, the travel times of grid cells are summed along flow paths and then convoluted to generate the hydrograph at the outlet. One central aspect of SDTT models that remains partially addressed is the effect of upstream flow contributions and their dynamics on the calculated flood wave travel times. Some methods neglect upstream contributions, but these are known to produce incorrect representations of the hydrological response. Other methods assume static upstream contributions, but the reliability of this approximation is poorly understood. In this study, we develop a new travel time method that accounts for dynamic upstream contributions. We test our method in three synthetic basins generated with a landscape evolution model that allows explicit control of primary watershed characteristics. We evaluate the method's performance for different storms by comparing its response to that produced by a fully distributed kinematic wave model. Furthermore, the method is tested in a real basin. We also analyze the dynamic behavior of the upstream contribution and travel times within the synthetic basins. Results show that existing static upstream contribution approaches in SDTT models do not adequately reproduce the hydrographs from the fully distributed kinematic wave model nor the observed hydrograph of the real basin. The proposed method improves the reproduction of hydrograph peak flows and temporal variability. Furthermore, the instantaneous unit hydrographs produced by the new method exhibit more positive skewness than the static approximations.
Precipitation From Persistent Extremes is Increasing in Most Regions and Globally
Authors: Du Haibo , Alexander Lisa V. , Donat Markus G. , Lippmann Tanya , Srivastava Arvind , Salinger Jim , Kruger Andries , Choi Gwangyong , He Hong S. , Fujibe Fumiaki , Rusticucci Matilde , Nandintsetseg Banzragch , Manzanas Rodrigo , Rehman Shafiqur , Abbas Farhat , Zhai Panmao , Yabi Ibouraïma , Stambaugh Michael C. , Wang Shengzhong , Batbold Altangerel , de Oliveira Priscilla Teles , Adrees Muhammad , Hou Wei , Zong Shengwei , Santos e Silva Claudio Moises , Lucio Paulo Sergio , Wu Zhengfang 
Published: May 2019

AbstractExtreme precipitation often persists for multiple days with variable duration but has usually been examined at fixed duration. Here we show that considering extreme persistent precipitation by complete event with variable duration, rather than a fixed temporal period, is a necessary metric to account for the complexity of changing precipitation. Observed global mean annual‐maximum precipitation is significantly stronger (49.5%) for persistent extremes than daily extremes. However, both globally observed and modeled rates of relative increases are lower for persistent extremes compared to daily extremes, especially for Southern Hemisphere and large regions in the 0‐45°N latitude band. Climate models also show significant differences in the magnitude and partly even the sign of local mean changes between daily and persistent extremes in global warming projections. Changes in extreme precipitation therefore are more complex than previously reported, and extreme precipitation events with varying duration should be taken into account for future climate change assessments.
CD271 is a molecular switch with divergent roles in melanoma and melanocyte development
Authors: Filipp Fabian V. , Li Chen , Boiko Alexander D. 
Published: May 2019

AbstractDysregulation of signaling networks controlling self-renewal and migration of developmental cell lineages is closely linked to the proliferative and invasive properties of tumors. Identification of such signaling pathways and their critical regulators is vital for successful design of effective targeted therapies against neoplastic tissue growth. The neurotrophin receptor (CD271/NGFR/p75NTR) is a key regulator of the melanocytic cell lineage through its ability to mediate cell growth, survival, and differentiation. Using clinical melanoma samples, normal melanocytes and global gene expression profiling we have investigated the role of CD271 in rewiring signal transduction networks of melanoma cells during neoplastic transformation. Our analysis demonstrates that depending on the cell fate of tumor initiation vs normal development, elevated levels of CD271 can serve as a switch between proliferation/survival and differentiation/cell death. Two divergent arms of neurotrophin signaling hold the balance between positive regulators of tumor growth controlled by E2F, MYC, SREBP1 and AKT3 pathways on the one hand, and differentiation, senescence, and apoptosis controlled by TRAF6/IRAK-dependent activation of AP1 and TP53 mediated processes on the other hand. A molecular network map revealed in this study uncovers CD271 as a context-specific molecular switch between normal development and malignant transformation.
The influence of progesterone on bovine uterine fluid energy, nucleotide, vitamin, cofactor, peptide, and xenobiotic composition during the conceptus elongation-initiation window
Authors: Simintiras Constantine A. , Sánchez José M. , McDonald Michael , Lonergan Patrick 
Published: May 2019

AbstractConceptus elongation coincides with one of the periods of greatest pregnancy loss in cattle and is characterized by rapid trophectoderm expansion, commencing ~ Day 13 of pregnancy, i.e. before maternal pregnancy recognition. The process has yet to be recapitulated in vitro and does not occur in the absence of uterine gland secretions in vivo. Moreover, conceptus elongation rates are positively correlated to systemic progesterone in maternal circulation. It is, therefore, a maternally-driven and progesterone-correlated developmental phenomenon. This study aimed to comprehensively characterize the biochemical composition of the uterine luminal fluid on Days 12–14 – the elongation-initiation window – in heifers with normal vs. high progesterone, to identify molecules potentially involved in conceptus elongation initiation. Specifically, nucleotide, vitamin, cofactor, xenobiotic, peptide, and energy metabolite profiles of uterine luminal fluid were examined. A total of 59 metabolites were identified, of which 6 and 3 displayed a respective progesterone and day effect, whereas 16 exhibited a day by progesterone interaction, of which 8 were nucleotide metabolites. Corresponding pathway enrichment analysis revealed that pyridoxal, ascorbate, tricarboxylic acid, purine, and pyrimidine metabolism are of likely importance to to conceptus elongation initiation. Moreover, progesterone reduced total metabolite abundance on Day 12 and may alter the uterine microbiome.
Bidirectional, Daily Temporal Associations between Sleep and Physical Activity in Adolescents
Authors: Master Lindsay , Nye Russell T. , Lee Soomi , Nahmod Nicole G. , Mariani Sara , Hale Lauren , Buxton Orfeu M. 
Published: May 2019

AbstractThis study evaluated the daily, temporal associations between sleep and daytime physical activity and sedentary behavior among adolescents from the Fragile Families & Child Wellbeing Study. A sub-sample of the cohort at age 15 (N = 417) wore actigraphy monitors for one week during the school year from which we derived daily minutes in sedentary and moderate-to-vigorous physical activity (MVPA) and nighttime sleep measures. Multilevel models tested temporal associations of nightly sleep onset, offset, duration, and sleep maintenance efficiency, with daily MVPA and sedentary behavior. More MVPA than an individual’s average was associated with earlier sleep onset (p < 0.0001), longer duration (p = 0.03), and higher sleep maintenance efficiency (p < 0.0001). On days with more sedentary behavior than an individual’s average, sleep onset and offset were delayed (p < 0.0001), duration was shorter (p < 0.0001), and sleep maintenance efficiency was higher (p = 0.0005). Conversely, nights with earlier sleep onset predicted more next-day sedentary behavior (p < 0.0001), and nights with later sleep offset and longer sleep duration were associated with less MVPA (p < 0.0001) and less sedentary time (p < 0.0001, p = 0.004) the next day. These bidirectional associations between sleep and physical activity suggest that promoting MVPA may help to elicit earlier bedtimes, lengthen sleep duration, and increase sleep efficiency, critical for healthy adolescent development.
Sexual dimorphism in Homo erectus inferred from 1.5 Ma footprints near Ileret, Kenya
Authors: Villmoare Brian , Hatala Kevin G. , Jungers William 
Published: May 2019

AbstractSexual dimorphism can be one of the most important indicators of social behavior in fossil species, but the effects of time averaging, geographic variation, and differential preservation can complicate attempts to determine this measure from preserved skeletal anatomy. Here we present an alternative, using footprints from near Ileret, Kenya, to assess the sexual dimorphism of presumptive African Homo erectus at 1.5 Ma. Footprint sites have several unique advantages not typically available to fossils: a single surface can sample a population over a very brief time (in this case likely not more than a single day), and the data are geographically constrained. Further, in many cases, the samples can be much larger than those from skeletal fossil assemblages. Our results indicate that East African Homo erectus was more dimorphic than modern Homo sapiens, although less so than highly dimorphic apes, suggesting that the Ileret footprints offer a unique window into an important transitional period in hominin social behavior.
Size and shape control of a variety of metallic nanostructures using tilted, rotating evaporation and lithographic lift-off techniques
Authors: Eschimese Damien , Vaurette François , Troadec David , Leveque Gaëtan , Melin Thierry , Arscott Steve 
Published: May 2019

AbstractHere, we demonstrate a simple top-down method for nanotechnology whereby electron beam (ebeam) lithography can be combined with tilted, rotated thermal evaporation to control the topography and size of an assortment of metallic objects at the nanometre scale. In order to do this, the evaporation tilt angle is varied between 1 and 24°. The technique allows the 3-dimensional tailoring of a range of metallic object shapes from sharp, flat bottomed spikes to hollow cylinders and rings—all of which have rotational symmetry and whose critical dimensions are much smaller than the lithographic feature size. The lithographic feature size is varied from 400 nm down to 40 nm. The nanostructures are characterized using electron microscopy techniques—the specific shape can be predicted using topographic modelling of the deposition. Although individual nanostructures are studied here, the idea can easily be extended to fabricate arrays for e.g. photonics and metamaterials. Being a generic technique—depending on easily controlled lithographic and evaporation parameters—it can be readily incorporated into any standard planar process and could be adapted to suit other thin-film materials deposited using physical means.
Brain structures and functional connectivity associated with individual differences in trait proactive aggression
Authors: Zhu Wenfeng , Zhou Xiaolin , Xia Ling-Xiang 
Published: May 2019

AbstractAlthough considerable efforts have been made to understand the neural underpinnings of (state) reactive aggression, which is triggered by provocation or perceived threat, little is known about the neural correlates of proactive aggression, which is driven by instrumental motivations to obtain personal gains through aggressive means and which varies dramatically across individuals in terms of tendency of appealing to such means. Here, by combining structural (grey matter density, GMD) and functional (resting-state functional connection, RSFC) fMRI, we investigated brain structures and functional networks related to trait proactive aggression. We found that individual differences in trait proactive aggression were positively associated with GMD in bilateral dorsolateral prefrontal cortex (DLPFC) and negatively correlated with GMD in posterior cingulate cortex (PCC); they were also negatively correlated with the strength of functional connectivity between left PCC and other brain regions, including right DLPFC, right IPL, right MPFC/ACC, and bilateral precuneus. These findings shed light on the differential brain bases of proactive and reactive aggressions and suggested the neural underpinnings of proactive aggression.
Removal of Arsenate and Chromate by Lanthanum-modified Granular Ceramic Material: The Critical Role of Coating Temperature
Authors: Yang Haiyan , Wang Yin , Bender John , Xu Shangping 
Published: May 2019

AbstractThe development of economical, low-maintenance, environmentally friendly and effective water filtration techniques can have far-reaching public health, social and economic benefits. In this research, a cost-effective La-modified granular ceramic material made of red art clay and recycled paper fiber was developed for the removal of two major anionic contaminants, As(V) (arsenate) and Cr(VI) (chromate). La modification temperature significantly impacted the resulting composition and properties of the adsorbents, and thus played a crucial role in the adsorbent performance. The La-modified ceramic materials were extensively characterized through scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET) surface area measurement, thermal gravimetric analysis (TGA), zeta potential measurements, and Fourier-transform infrared spectroscopy (FTIR) analysis. The characterization results suggested that surface coating by LaONO3-related compounds was critical for As(V) and Cr(VI) adsorption. At the modification temperature of 385 °C, the adsorption of As(V) and Cr(VI) reached maximum, which were 23 mg/g and 13 mg/g, respectively, under circumneutral conditions that are relevant to various aquatic systems. The adsorption kinetics and isotherm, the influence of pH, ionic strength and coexisting anions on As(V) and Cr(VI) adsorption were investigated to further understand both As(V) and Cr(VI) adsorption behavior. Findings from this research showed that La-modified ceramic material made of recycled paper waste represents a cost-effective adsorbent for anionic contaminant removal under environmentally relevant conditions.
Dietary tryptophan deficiency and its supplementation compromises inflammatory mechanisms and disease resistance in a teleost fish
Authors: Machado M. , Azeredo R. , Domingues A. , Fernandez-Boo S. , Dias J. , Conceição L. E. C. , Costas B. 
Published: May 2019

AbstractTryptophan participates on several physiological mechanisms of the neuroendocrine-immune network and plays a critical role in macrophages and lymphocytes function. This study intended to evaluate the modulatory effects of dietary tryptophan on the European seabass (Dicentrarchus labrax) immune status, inflammatory response and disease resistance to Photobacterium damselae piscicida. A tryptophan deficient diet (NTRP); a control diet (CTRL); and two other diets supplemented with tryptophan at 0.13% (TRP13) and 0.17% (TRP17) of feed weight were formulated. Fish were sampled at 2 and 4 weeks of feeding and the remaining were i.p. injected with Phdp (3 × 106 cfu/fish) at 4 weeks and the inflammatory response (at 4, 24, 48 and 72 hours post-infection) as well as survival were evaluated. Results suggest that fish immune status was not altered in a tryptophan deficient scenario whereas in response to an inflammatory insult, plasma cortisol levels increased and the immune cell response was compromised, which translated in a lower disease resistance. When dietary tryptophan was offered 30% above its requirement level, plasma cortisol increased and, in response to bacterial infection, a decrease in lymphocytes, monocytes/macrophages and several immune-related genes was observed, also compromising at some degree fish disease resistance.