bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased compliance with tumor treating fields therapy is prognostic for improved survival in the treatment of glioblastoma: a subgroup analysis of the EF-14 phase III trial
Authors: Toms S. A. , Kim C. Y. , Nicholas G. , Ram Z. 
Published: December 2018

AbstractBackgroundTumor treating fields (TTFields) is a non-invasive, antimitotic therapy. In the EF-14 phase 3 trial in newly diagnosed glioblastoma, TTFields plus temozolomide (TTFields/TMZ) improved progression free (PFS) and overall survival (OS) versus TMZ alone. Previous data indicate a ≥ 75% daily compliance improves outcomes. We analyzed compliance data from TTFields/TMZ patients in the EF-14 study to correlate TTFields compliance with PFS and OS and identify potential lower boundary for compliance with improved clinical outcomes.MethodsCompliance was assessed by usage data from the NovoTTF-100A device and calculated as percentage per month of TTFields delivery. TTFields/TMZ patients were segregated into subgroups by percent monthly compliance. A Cox proportional hazard model controlled for sex, extent of resection,MGMTmethylation status, age, region, and performance status was used to investigate the effect of compliance on PFS and OS.ResultsA threshold value of 50% compliance with TTFields/TMZ improved PFS (HR 0.70, 95% CI 0.47–1.05) and OS (HR 0.67, 95% CI 0.45–0.99) versus TMZ alone with improved outcome as compliance increased. At compliance > 90%, median survival was 24.9 months (28.7 months from diagnosis) and 5-year survival rate was 29.3%. Compliance was independent of gender, extent of resection,MGMTmethylation status, age, region and performance status (HR 0.78; p = 0.031; OS at compliance ≥ 75% vs. < 75%).ConclusionA compliance threshold of 50% with TTFields/TMZ correlated with significantly improved OS and PFS versus TMZ alone. Patients with compliance > 90% showed extended median and 5-year survival rates. Increased compliance with TTFields therapy is independently prognostic for improved survival in glioblastoma.
Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design
Authors:   On behalf of EVA Collaborators, Raparelli Valeria , Proietti Marco , Lenzi Andrea , Basili Stefania 
Published: December 2018

Abstract
Improvements in ischemic heart disease (IHD) management have been unbalanced between sexes, with coronary microvascular dysfunction considered the likely underlying reason. The Endocrine Vascular disease Approach (EVA) is an observational study (Clinicaltrial.gov NCT02737982) aiming to assess sex and gender interactions between coronary circulation, sexual hormones, and platelet function. Consecutive patients with IHD undergoing coronary angiography will be recruited: (1) to assess sex and gender differences in angiographic reperfusion indexes; (2) to evaluate the effects of estrogen/androgen on sex-related differences in myocardial ischemia; (3) to investigate the platelet biology differences between men and women with IHD; (4) to verify sex- and gender-driven interplay between response to percutaneous coronary intervention, platelets, sex hormones, and myocardial damage at baseline and its impact on 12-month outcomes. The integration of sex and gender in this translational project on IHD will contribute to the identification of new targets for further innovative clinical interventions.
Discriminating Tectonic and Magmatic Fabrics in the Remal Granite Gneiss: Implications for Terrane Amalgamation Processes in Southeastern Singhbhum, India
Authors: Dobe Ritabrata , Gupta Saibal 
Published: December 2018

ABSTRACT
The Remal granite gneiss body in the southeastern part of the Singhbhum Craton, near its contact with the Rengali Province, preserves two orthogonal penetrative foliations. The subhorizontal foliation defines cross and trough bedding structures, and is characterized by (i) systematic grain-size variation between the layers, (ii) the presence of feldspar laths and (iii) graphic intergrowth textures, confirming that it is primary and of igneous origin (Sign). Sign has a non-planar geometry and shows a spread in orientations, while a later foliation of tectonic origin is defined by alternating biotite-rich and biotite poor bands that define a consistently oriented gneissic foliation (S1). S1 gneissic layering is associated with the alignment of biotite flakes and myrmekite formation, and operated under low grade metamorphic conditions. S1 shows a remarkable similarity in orientation with the shear fabric along the amalgamation front of the Rengali Province with the Eastern Ghats Province further to the south, indicating that strain related to this regional strike-slip event can be identified even in southeastern Singhbhum.
Seismic Cycles and Trend Predictions of Earthquakes in Sumatra – Andaman and Burmese Subduction Zones using Temporal b-value and Hurst Analysis
Authors: Sengupta Diptansu , Mukhopadhyay Basab , Mishra Om Prakash 
Published: December 2018

ABSTRACT
The annual b-value fluctuation patterns in Burmese subduction zone and Andaman – Sumatra subduction zone are evaluated from earthquake data (January 1990 to June 2016; Mw ≥ 4.3) to identify seismic cycles with sequential dynamic phases as described in the ‘elastic failure model’ of Main et al. (1989). Two seismic cycles have been identified in Andaman – Sumatra subduction zone, one started in 1990 and ended on 2004 with occurrence of great Sumatra earthquake (Mw 9.0) and the other started in 2005 and continuing till date with the phase of crack coalescence and fluid diffusion (3A&B). Similarly, the subduction zone of Burma shows evidence of one incomplete seismic cycle within 1990-2016 and presently undergoing the crack coalescence and fluid diffusion (3A&B) phase. The analysis has prompted to subdivide the area into thirteen smaller seismic blocks (A to M) to analyse area specific seismic trend and vulnerability analysis employing Hurst Statistics. Hurst plots with the dynamic phases of ‘elastic failure model’ of earthquake generation is compared to assess the blocks with high seismic vulnerability. The analysis suggest that north Andaman zone (block G) and north Burma fold belt (block M) are seismically most vulnerable. Moreover, the seismic vulnerability of Tripura fold belt and Bangladesh plain (block K) is equally high.
Satellite-Derived Regional Apparent Thermal Inertia and Gravity for Mapping Different Rock Types in Parts of Banswara, Rajasthan
Authors: Rani (Pasricha) Komal , Guha Arindam , Pal Sanjit Kumar 
Published: December 2018

ABSTRACT
In this study, utility of satellite derived Apparent Thermal Inertia (ATI) and residual gravity data have been analyzed for delineating the major rock types of Aravalli Supergroup. Density is a common contributing factor responsible for ATI and gravity variations of rock types. In addition to density, thermal inertia is also controlled by specific heat and thermal conductivity. In the present study, MODIS (Moderate resolution imaging spectrometer) day and consecutive night time land surface temperature (LST), albedo data have been processed to derive ATI image for the study area. On the other hand, Bouguer gravity generated from EIGEN6C4 gravity model data is processed to derive the residual gravity over the study area. It has been observed that ATI values of different rock types are influenced by the variations in weathering pattern and forest cover developed over the rock in addition to the thermophysical parameters of rocks. Forest cover and agricultural activity are responsible for shifting the ATI values to higher side for any rocks due to evapotranspiration; which is responsible for reducing day and night land surface temperature difference. ATI pixels(collected from large rock pavements) of different rocks can however, be used to discriminate them from each other. Conjugate analysis of residual gravity and ATI has been proved useful to discriminate different rock types of spatially well distributed rock exposures. It is found that ATI and gravity values are well correlated for the spatially large surface exposures of rocks. In regional scale, low frequency changes of ATI broadly matches with the changes observed on the corresponding spatial profiles of residual gravity with some localized variations. This is due to the fact that shallow surface gravity anomaly is cumulative effect of vertical and horizontal variations of density in contrast to ATI which is more sensitive to near surface density, conductivity and specific heat variations of rocks. Moreover, high frequency variations imprinted on regional ATI spatial profiles are due to the cumulative effect of complex thermophysical properties of surface elements (weathering residuum, surface moisture variations) density variation and intrinsic thermophysical properties of rocks measured at regional scale. High frequency changes of ATI do not correspond well with residual gravity variation.
Development of Earthquake Event Detection Technique Based on STA/LTA Algorithm for Seismic Alert System
Authors: Kumar Satish , Vig Renu , Kapur Pawan 
Published: December 2018

ABSTRACT
Among natural disasters, earthquake is the most common calamity which result in a wide spectrum of destruction, loses of property and human life. In order to mitigate the damage impact, there is an urgent need to realize a technological solution for vital installations i.e. Seismic alert system (SAS). It is a solution to avert colossal loss as earthquake forecasting is not yet possible and is being devised for regional notification for a possible mitigation while it is in active mode. For designing SAS, a network of seismic sensing node (SSN) is to be configured to detect the seismic activity in the region of interest. SSN discriminates between local noise and seismic event in real time using inbuilt event detection technique. The true seismic event is declared on satisfying the field parameters programmed by the user i.e. short and long duration window, threshold ratio, stability factor, de-threshold ratio, number of threshold channels, sampling rate, pre-event and post-event duration, number of channel and packet size duration. This paper illustrates the design aspects related to the event detection technique incorporated in the seismic node of the alert system and configured around the seismic sensors, 24-bit high resolution digitizers, GPS modules, etc. The results are validated by varying the different field parameters on recorded signal.
Heliborne Time Domain Electromagnetic Data Aiding Delineation of Carbonaceous Shale in Southwestern Part of Bijawar Basin and its Implication on Basinal Stratigraphy
Authors: Pathak K. , Yalla Harsha , Singh R. P. , Chaturvedi A. K. 
Published: December 2018

ABSTRACT
Geophysical methods are tools to unravel concealed geological features that enhance knowledge. Heliborne time domain electro-magnetic (TDEM) survey carried out over volcano-sedimentary sequence of Palaeoproterozoic Bijawar basin indicated presence of conductor in the western part of the basin. Subsequently boreholes drilled intercepted rhythmites made up of carbonaceous shale and dolomite within Bajno dolomite Formation. Measurement of conductivity on core samples established the high conductive carbonaceous shale as the contributor for TDEM response. TDEM signature indicate widespread presence of rhythmites in the western part of Bijawar basin reflecting different hydrodynamic condition from other parts of Bajno dolomite. Thus, Bajno dolomite Formation is classified into two members viz. Tigoda member and Sarwa member.
Geotechnical Facets of Active Sediments and its Bearing on Natural Hazards and Mitigation Measures: An Approach on Sediments of the Nubra Valley (Ladakh), Trans-Himalaya, India
Authors: Dubey R. K. , Dar J. A. , Satyam Gyan Prakash 
Published: December 2018

ABSTRACT
The paper highlights the geotechnical attributes of Quaternary stratified sediments in Trans-Himalayan zone around the Nubra Valley (Ladakh), India for classifying the sediment’s sequences and characterizing their participation in natural hazards susceptibility and mitigation measures. The study is based on the experimental works performed on collected samples of sediments at different sites and depths (1.5 to 5.5 m) of sequences for determination of grain size sensitive parameters and geotechnical characteristics as per American Society for Testing and Materials standard and with help of empirical relationships. The results reveal that the majority of sediments are bimodal distributed with wide variation in uniformity coefficients (1.84-5.0), low variation in coefficient of curvatures (0.5-0.61) and sorting coefficient (1.12-1.69) exhibit wide range of shear strengths (25 kPa to 130 kPa), cohesions (0.02-0.13 kg/cm2) and angles of internal frictions (36°-45°) which may be due to distinct differences in their densities, void ratios, liquid and plastic limits. Based on geotechnical values, the sediments strata can be categorized as foot-hill debris zone, normal sediment (soil) zone and active sediment (soil) zone. The foot-hill debris zone is found more prone to mass-wasting due to influence of gravity and their low binding habits. The active sediment (soil) zone exhibits lower shear strengths and cohesions in comparison to normal sediments due to higher liquid and plastic limits of sediments exposed to freezing and thawing actions. This zone is found more susceptible to slope instabilities and differential settlements hazards, hence requires specific care during engineering establishments and mitigation measures in the valley.
The clinical impact of a urinary tract infection management bundle in a tertiary-care teaching hospital
Authors: MacLaggan Timothy D. , Le Christopher P. , Iverson Kristen A. , Ellis Chelsey L. , Allard Jacques , Wilcox-Carrier Tammie J. , Smyth Daniel J. 
Published: December 2018

AbstractObjectiveThe aim of this study was to assess the impact of a urinary tract infection (UTI) management bundle to reduce the treatment of asymptomatic bacteriuria (AB) and to improve the management of symptomatic UTIs.DesignBefore-and-after intervention study.SettingsTertiary-care hospital.PatientsConsecutive sample of inpatients with positive single or mixed-predominant urine cultures collected and reported while admitted to the hospital.MethodsThe UTI management bundle consisted of nursing and prescriber education, modification of the reporting of positive urine cultures, and pharmacists’ prospective audit and feedback. A retrospective chart review of consecutive inpatients with positive urinary cultures was performed before and after implementation of the management bundle.ResultsPrior to the implementation of the management bundle, 276 patients were eligible criteria for chart review. Of these 276 patients, 165 (59·8%) were found to have AB; of these 165 patients with AB, 111 (67·3%) were treated with antimicrobials. Moreover, 268 patients met eligibility criteria for postintervention review. Of these 268, 133 patients (49·6%) were found to have AB; of these 133 with AB, 22 (16·5%) were treated with antimicrobials. Thus, a 75·5% reduction of AB treatment was achieved. Educational components of the bundle resulted in a substantial decrease in nonphysician-directed urine sample submission. Adherence to a UTI management algorithm improved substantially in the intervention period, with a notable decrease in fluoroquinolone prescription for empiric UTI treatment.ConclusionsA UTI management bundle resulted in a dramatic improvement in the management of urinary tract infection, particularly a reduction in the treatment of AB and improved management of symptomatic UTI.
Association of Dietary Inflammatory Index with anthropometric indices in children and adolescents: the weight disorder survey of the Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease (CASPIAN)-IV study
Authors: Aslani Zahra , Qorbani Mostafa , Hébert James R. , Shivappa Nitin , Motlagh Mohammad Esmaeil , Asayesh Hamid , Mahdavi-Gorabi Armita , Kelishadi Roya 
Published: December 2018

AbstractThis study aimed to assess the relationship between the Dietary Inflammatory Index (DII®), a validated tool for evaluating diet-associated inflammation, and anthropometric indices in children and adolescents. This multicentre survey was conducted on 5427 school students selected via multistage cluster sampling from thirty provinces of Iran. This survey was conducted under the framework of the weight disorders survey, which is part of a national surveillance programme entitled Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Diseases-IV. For calculating the DII scores, twenty-five dietary factors were obtained from a validated 168-item FFQ. Height, weight, wrist circumference, neck circumference (NC), waist circumference (WC) and hip circumference (HC) were measured. BMIz-score, waist circumference:hip circumference ratio (WHR), waist circumference:height ratio (WHtR) and parental BMI were computed. Linear regression models were used to evaluate the association of DII and anthropometric indices. Significant trends were observed across quartiles of DII score for all anthropometric indices in all participants (P<0·05), except for WHR and WHtR. After adjustment for potential confounders, the multiple linear regression analysis for each anthropometric index revealed that participants in the highest DII quartile had higher BMIz-score, WC, HC and parental BMI compared with those in the first (or lowest) quartile. In summary, we found that a pro-inflammatory diet was associated with higher BMIz-score, wrist circumference, NC, WC, HC and parental BMI. The large sample size of the present study may influence the statistical significance of observed associations. Hence, the findings should be clinically interpreted with caution.
Spaces which Invert Weak Homotopy Equivalences
Authors: Barmak Jonathan Ariel 
Published: December 2018

AbstractIt is well known that if X is a CW-complex, then for every weak homotopy equivalence f : A → B, the map f* : [X, A] → [X, B] induced in homotopy classes is a bijection. In fact, up to homotopy equivalence, only CW-complexes have that property. Now, for which spaces X is f* : [B, X] → [A, X] a bijection for every weak equivalence f? This question was considered by J. Strom and T. Goodwillie. In this note we prove that a non-empty space inverts weak equivalences if and only if it is contractible.
Association between spousal violence and the incidence of acute respiratory infection among children under five: random-effect modelling using data from Nigeria and Bangladesh
Authors: Hossain Mian B. , Udo Ifeyinwa , Phillips James F. 
Published: December 2018

AbstractAcute respiratory infection (ARI) is a major cause of mortality among children under the age of five in developing countries. This paper examines Demographic and Health Survey (DHS) data on maternal recall of episodes of ARI in the contrasting settings of Bangladesh and Nigeria, where about 11.1% and 3.3% of under-5 children, respectively, are reported to have symptoms of ARI. The surveys found that about 25.6% of married Bangladeshi women and 15.4% of married Nigerian women reported experiencing spousal violence in the past year. To test the proposition that women’s experience of intimate partner violence (IPV) is associated with adversity in their children, the study examined the relationship between spousal violence in the past year and childhood ARI in the past 2 weeks among children under the age of five in Bangladesh and Nigeria. Data were taken from a nationally representative sample of mothers aged 15–49 years obtained from the 2007 Bangladesh DHS and 2008 Nigeria DHS. Random-effects multiple logistic regression models were estimated to assess the association of maternal exposure to IPV with the incidence of ARI in the past 2 weeks among under-5 children after controlling for the potentially confounding effects of maternal social and demographic characteristics. Results from Nigeria suggest that the odds of ARI incidence among children of mothers who were IPV victims were almost two times higher than among their counterparts whose mothers had not experienced IPV (OR = 1.78; 95% CI: 1.45–2.19; p <0.001). Similarly, the odds for the children of Bangladeshi IPV victims were elevated one and half times (OR = 1.61; 95% CI: 1.21–2.14; p <0.001). The findings suggest that under-5 children suffer indirect health consequences of gender-based violence.
A survey of large-scale reasoning on the Web of data
Authors: Antoniou Grigoris , Batsakis Sotiris , Mutharaju Raghava , Pan Jeff Z. , Qi Guilin , Tachmazidis Ilias , Urbani Jacopo , Zhou Zhangquan 
Published: December 2018

AbstractAs more and more data is being generated by sensor networks, social media and organizations, the Web interlinking this wealth of information becomes more complex. This is particularly true for the so-called Web of Data, in which data is semantically enriched and interlinked using ontologies. In this large and uncoordinated environment, reasoning can be used to check the consistency of the data and of associated ontologies, or to infer logical consequences which, in turn, can be used to obtain new insights from the data. However, reasoning approaches need to be scalable in order to enable reasoning over the entire Web of Data. To address this problem, several high-performance reasoning systems, which mainly implement distributed or parallel algorithms, have been proposed in the last few years. These systems differ significantly; for instance in terms of reasoning expressivity, computational properties such as completeness, or reasoning objectives. In order to provide a first complete overview of the field, this paper reports a systematic review of such scalable reasoning approaches over various ontological languages, reporting details about the methods and over the conducted experiments. We highlight the shortcomings of these approaches and discuss some of the open problems related to performing scalable reasoning.
An outbreak of norovirus infection caused by ice cubes and a leaking air ventilation valve
Authors: Jalava K. , Kauppinen A. , Al-Hello H. , Räsänen S. 
Published: December 2018

AbstractA gastrointestinal outbreak was reported among 154 diners who attended a Christmas buffet on the 9 and 10 December 2016. A retrospective cohort study was undertaken. Faecal samples, water, ice and an air ventilation device were tested for indicators and routine pathogens. Altogether 26% (24/91) fulfilled the case definition of having typical viral gastrointestinal symptoms. Norovirus genogroup I was detected in faecal samples from three cases. One of these cases tested positive also for sapovirus and had a family member testing positive for both norovirus and sapovirus. A diner who drank water or drinks with ice cubes (risk ratios (RR) 6.5, 95% confidence intervals (CI) 1.5–113.0) or both (RR 8.2, 95% CI 1.7–145.5) had an increased risk in a dose-response manner. Ice cubes from three vending machines had high levels of heterotrophic bacteria. A faulty air ventilation valve in the space where the ice cube machine was located was considered a likely cause of this outbreak. Leaking air ventilation valves may represent a neglected route of transmission in viral gastrointestinal outbreaks.