bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of G-CSF in Congestive Heart Failure Treatment
Authors: Pourtaji Atena , Jahani Vajiheh , Moallem Seyed Mohammad Hassan , karimani Asieh , Mohammadpour Amir Hooshang 
Published: October 2018

Introduction: Congestive Heart Failure (CHF) is a disorder in which the heart is unable
to supply enough blood for body tissues. Since heart is an adaptable organ, it overcomes this condition
by going under remodeling process. Considering cardiac myocytes are capable of proliferation
after MI, stimulation of neovascularization as well as their regeneration might serve as a novel target
in cardiac remodeling prevention and CHF treatment. Granulocyte Colony-Stimulating Factor
(G-CSF), is a hematopoietic cytokine that promotes proliferation and differentiation of neutrophils
and is involved in cardiac repair after MI. So far, this is the first review to focus on GCSF as a
novel treatment for heart failure.

Methods:
We conducted a search of some databases such as PubMed for articles and reviews published
between 2003 and 2017, with different keywords including “G-CSF”, “congestive heart failure”,
“new therapies for CHF”, “filgrastim”, “in vivo study”.

Results:
GCSF exerts its beneficial effects on cardiac repair through either stem cell mobilization
or direct angiogenesis promotion. All of which are capable of promoting cardiac cell repair.

Conclusion:
GCSF is a promising target in CHF-therapy by means of cardiac repair and remodeling
prevention through multiple mechanisms, which are effective enough to be used in clinical
practice.
The Impact of Maternal Voice on the Fetus: A Systematic Review
Authors: Carvalho Maria Eduarda Salgado , de Miranda Justo João Manuel Rosado , Gratier Maya , da Silva Helena Maria Ferreira	Rodrigues 
Published: October 2018

Background:
Studies have shown pre-natal memory underlining the ability of newborns
to discriminate maternal vs. other voices and to recognize linguistic stimuli presented prenatally by
the mother. The fetus reacts to maternal voice at the end of gestation but it is important to clarify the
indicators and conditions of these responses.

Objective:
To understand the state of the art concerning: 1) indicators of fetal reactions to maternal
voice vs. other voices; 2) conditions of maternal voice required to obtain fetal response, 3) neonatal
recognition of maternal voice and of linguistic material presented prenatally and 4) obstetric and
behavioral maternal conditions compromising fetal ability to discriminate between maternal and
other female voices.

Method:
Systematic review using EBSCO, WEBSCIENCE and MEDLINE. Eligibility: studies
with maternal voice delivered before birth as stimulus and with fetal or neonatal behavior as responses.

Results: Fetal responses to maternal voice are observed through fetal cardiac, motor (fetal yawning
decrease, mouth opening, fetal body movements) and brain responses (activation of the lower bank
of the left temporal lobe). Newborns’ head orientation and non-nutritive sucking are shown as being
neonatal indicators.

Conclusion:
Gestational age, baseline measures (fetal state, acoustic conditions and pre-stimulus
time) and obstetrical conditions may enable or compromise fetal discrimination between maternal
and other voices. The role of maternal voice for prenatal human bonding needs to be discussed according
to different maternity conditions such as surrogate mothers. A new paradigm is suggested;
the focus of research should be on maternal-fetal interaction under the presence of maternal voice.</P>
Bioactive Polyphenols as Promising Natural Medicinal Agents Against Cancer: The Emerging Trends and Prospective Goals
Authors: Prakash Om , Usmani Shazia , Gupta Amresh , Singh Ruchi , Singh Namrata , Ved Akash 
Published: October 2018

Background:
There is much epidemiological evidence that fruits, vegetables, medicinal
plants, and their phytochemicals could lower the progression and development of various forms of cancer.
The plants are active reservoirs for novel chemical entities and provide a promising resource for the
management of cancer.

Methods:
Several analyses have signified that bioactive flavonoids and phenolic acids might be widely
practiced for the management as well as therapy of numerous carcinomas.

:
A large number of research works are now focusing on natural polyphenolic compounds and trying to
find out new and more effective treatment strategies for cancer patients.

Results:
The probable mechanism comprises anti-oxidant, anti-inflammation, apoptosis and induces
inhibition of cell proliferation along with genomic phenomena elaborated in cancer therapy.

Conclusion:
In the last five years, studies investigated the antitumor potential of common polyphenolic
groups (phenolic acids, flavonoids, lignins, resveratrol, stilbene, quercetin etc.) exploring the prospective
mechanism, based on epidemiological data thus reporting therapeutic evidence and various clinical
examinations.
Biperiden-Induced Delirium In A Five-Years Old Child
Authors: Kınay Duygu , Soyata Ahmet Zihni 
Published: October 2018

Objective:
Extrapyramidal adverse effects of antipsychotic drugs are more reported in
children. Biperiden is an anticholinergic agent to treat the adverse effects of antipsychotic drugs. The
drug has the potential to induce delirium at toxic doses. However, data are scarce about delirium
associated with biperiden in children. Thus far, a case of delirium has been associated with biperiden in
an adolescent patient. We report the first case of delirium associated with the use of biperiden in a
preadolescent patient.

Case Report:
A boy aged five years and weighing 20 kilograms had been diagnosed as having
oppositional defiant disorder and separation anxiety disorder in the previous treatment center. Ten
milligrams fluoxetine and 0.25 milligrams risperidone had been initiated. On the third day of treatment,
dystonia developed and he was administered with biperiden. An hour later, he was brought to our
emergency clinic due to disorganized speech and behavior. His vital signs were stable. There were no
findings in blood and urine tests. No electrolyte imbalance, liver, kidney, and thyroid dysfunction have
been observed. His neurologic examination was unremarkable and no abnormal findings were shown
on cranial magnetic resonance imaging. No other system findings or findings pointing out to infectious
diseases have been observed. One milligram physostigmine was administered with intravenous
infusion. However, symptoms did not resolve and he was diagnosed with delirium. Naranjo Adverse Drug
Reaction Probability Scale score was seven, indicating a “Probable” Adverse Drug Reaction. Half
milligram haloperidol was administered bid for three days and he was discharged with complete recovery.

Conclusion:
Clinicians must be aware of the risk of delirium when using non-toxic doses of biperiden
in young children.
[10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDAMB- 231 Breast Tumor Cells
Authors: Fuzer Angelina M. , Martin Ana C.B.M. , Becceneri Amanda B. , da Silva James A. , Vieira Paulo C. , Cominetti Marcia R. 
Published: October 2018

Background:
Triple Negative Breast Cancer (TNBC) represents the approximately 15% of breast cancers
that lack expression of Estrogen (ER) and Progesterone Receptors (PR) and do not exhibit amplification of the human
epidermal growth factor receptor 2 (HER2) gene, imposing difficulties to treatment. Interactions between tumor
cells and their microenvironment facilitate tumor cell invasion in the surrounding tissues, intravasation through
newly formed vessels, and dissemination to form metastasis. To treat metastasis from breast and many other cancer
types, chemotherapy is one of the most extensively used methods. However, its efficacy and safety remain a primary
concern, as well as its toxicity and other side effects. Thus, there is increasing interest in natural antitumor agents.
In a previous work, we have demonstrated that [10]-gingerol is able to revert malignant phenotype in breast cancer
cells in 3D culture and, moreover, to inhibit the dissemination of TNBC to multiple organs including lung, bone and
brain, in spontaneous and experimental in vivo metastasis assays in mouse model.

Objective:
This work aims to investigate the in vitro effects of [10]-gingerol, using human MDA-MB-231TNBC
cells, in comparison to non-tumor MCF-10A breast cells, in order to understand the antitumor and antimetastatic
effects found in vivo and in a 3D environment.

Methods:
We investigated different steps of the metastatic process in vitro, such as cell migration, invasion, adhesion
and MMP activity. In addition, we analyzed the anti-apoptotic and genotoxic effects of [10]-gingerol using PEAnnexin,
DNA fragmentation, TUNEL and comet assays, respectively.

Results:
[10]-gingerol was able to inhibit cell adhesion, migration, invasion and to induce apoptosis more effectively in
TNBC cells, when compared to non-tumor cells, demonstrating that these mechanisms can be involved in the antitumor
and antimetastatic effects of [10]-gingerol, found both in 3D culture and in vivo.

Conclusion:
Taken together, results found here are complementary to previous studies of our group and others and
demonstrate that additional mechanisms, besides apoptotic cell death, is used by [10]-gingerol to accomplish its antitumor
and antimetastatic effects. Our results indicate a potential for this natural compound as an antitumor molecule or
as an adjuvant for chemotherapeutics already used in the clinic.
Understanding Genotypes and Phenotypes of the Mutations in Voltage- Gated Sodium Channel α Subunits in Epilepsy
Authors: Feng Yijun , Zhang Shuzhang , Zhang Zhiping , Guo Jingkang , Tan Zhiyong , Zhu Yudan , Tao Jie , Ji Yong-Hua 
Published: October 2018

Background & Objective:
Voltage-gated sodium channels (VGSCs) are responsible for the
generation and propagation of action potentials in most excitable cells. In general, a VGSC consists of
one pore-forming α subunit and two auxiliary β subunits. Genetic alterations in VGSCs genes, including
both α and β subunits, are considered to be associated with epileptogenesis as well as seizures.
This review aims to summarize the mutations in VGSC α subunits in epilepsy, particularly the pathophysiological
and pharmacological properties of relevant VGSC mutants.

Conclusion:
The review of epilepsy-associated VGSC α subunits mutants may not only contribute to
the understanding of disease mechanism and genetic modifiers, but also provide potential theoretical
targets for the precision and individualized medicine for epilepsy.
Study of Antihyperglycemic, Antihyperlipidemic and Antioxidant Activities of Tannins Extracted from Warionia saharae Benth. & Coss
Authors: Ajebli Mohammed , El Ouady Fadwa , Eddouks Mohamed 
Published: October 2018

Background and Objective: Warionia saharae Benth & Coss, a plant belonging to Asteraceae
family, is used for its anti-diabetic properties in Morocco. The objective of this study was to
evaluate the effect of tannins extracted from Warionia saharae (W. saharae) on blood glucose levels
and lipid profile in normal and streptozotocin(STZ)-induced diabetic rats.

Methods:
Tannins (TE) were extracted from W. saharae using Soxhlet apparatus and different organic
solvents. Single and once daily repeated oral administration of TE (10 mg/kg) for 15 days were used to
evaluate the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test
tolerance, liver histopathological examination and in vitro antioxidant activity of TE were carried out
in this study.

Results:
The results showed that TE was able to exert antihyperglycemic and lowering total cholesterol
effects as well as improvement of the high-density lipoprotein (HDL)-cholesterol serum level after 15
days of treatment. Furthermore, TE improved glucose tolerance, histopathological status of liver in
diabetic rats and demonstrated interesting antioxidant activity.

Conclusion:
In conclusion, the present investigation revealed that TE possesses potent antidiabetic and
antihyperlipidemic activities as claimed in different ethnopharmacological practices.
Elastic Changes of the Coracohumeral Ligament Evaluated with Shear Wave Elastography
Authors: Kanazawa Kenji , Hagiwara Yoshihiro , Sekiguchi Takuya , Fujita Ryo , Suzuki Kazuaki , Koide Masashi , Ando Akira , Yabe Yutaka 
Published: October 2018

Background:
Although the shoulder range of motion significantly decreases with advancing age, how the natural aging process affects the joint capsule, including the Coracohumeral Ligament (CHL), in healthy subjects is still unknown.

Objective
To use shear wave elastography to investigate the correlations between age, sex, and shoulder dominance, and elasticity of the CHL in healthy individuals.

Methods:
Eighty-four healthy volunteers (mean age: 42.6; 39 men) were included in this study. They were divided into five groups based on age: 20s (20–29, n = 19), 30s (30–39, n = 17), 40s (40–49, n = 20), 50s (50–59, n = 13), and 60s (60–69, n = 15) groups. The elasticity of the CHL in the bilateral shoulders was evaluated at the neutral and 30° external rotation (ER at 30°) positions with the arm at the side while laying supine.

Results:
The elastic modulus was significantly greater in ER at 30° than in the neutral position regardless of sex or shoulder dominance (P < 0.001). Significant positive correlations between age and elasticity of the CHL were observed in both the neutral and ER at 30° positions regardless of shoulder dominance. Elasticity of the CHL was significantly greater with increasing age in both the neutral and ER at 30° positions on the dominant (P = 0.0022, P < 0.001, respectively) and non-dominant sides (P = 0.0199, 0.0014).

Conclusion:
The elasticity of the CHL increased with age, and the ER at 30° position could demonstrate faint changes in CHL elasticity.

Level of Evidence:
Level 3 Case-control study.
HIV Positive Patients' Experience of Receiving Health Care Services: A Phenomenology Study in Iran
Authors: Asadi Heshmatollah , Imani-Nasab Mohammad-Hasan , Garavand Ali , Hasoumi Mojtaba , Kia Abdollah Almasian , Haghi Behzad , Setoodehzadeh Fatemeh 
Published: October 2018

Introduction:Most of the studies on HIV/AIDS health care status are usually conducted in big cities while small towns and rural areas are faced with specific challenges. This study aimed to identify the barriers and problems encountered by HIV-positive patients when receiving health services in the small cities and rural areas of Iran.Methodology:This is a qualitative study that was conducted using an interpretive phenomenology method in 2016. This study was conducted through a semi-structured interview for which a purposeful sampling method was used. In the present study, data saturation was observed after 15 interviews, but more than 17 interviews were conducted to ensure the reliability of the interview. Data were analyzed by Colaizzi's method using MAXQDA10 software.Findings:Barriers and problems encountered by patients when receiving health care services consisted of 10 categories, 32 main themes and 67 sub-themes. The categories were as follows: fear of revealing the disease, fear of confronting providers, seeking support, not visiting health care providers, inappropriate behavior of health care staff, concealing the disease, hardship endurance, financial concerns, psychological stress and pressure, and disclosure of patient information.Conclusion:Recognizing the problems of HIV-positive patients in using health care services and resolving them can help to reassure the patients about the health system. Introduction of supporting policies and regulations, appropriate public education, training health sector personnel, and provision of medical equipment and facilities would positively affect the process of solving the problems of HIV-Patients (treating HIV patients).
A Binary Particle Swarm Optimization for IC Floorplanning
Authors: Singh Rajendra Bahadur , Baghel Anurag Singh , Solanki Arun 
Published: October 2018

Background:
In the field of IC physical design, there is a big problem in the IC floorplanning
to find the early feedback to estimate the area, wire length, delay, etc. before IC fabrication.

Objective:
In this paper, minimization of the area and total wire length on the IC has been done using
Binary Particle Swarm Optimization with sequence pair representation.

Methods:
Optimization of the IC floorplan works in two phases. In the first phase, the floorplan is
constructed by sequence pair representation without any overlapping of the modules on IC floorplan.
In the second phase, Binary Particle Swarm Optimization algorithm explores the packing of all
modules in floorplan to find better optimal performances i.e. area and wire length.

Results:
The results obtained were compared with the solutions derived from other meta-heuristic
algorithms, the area is improved maximum up to 10% and the wire length was improved maximum
up to 28%.

Conclusion:
The Experimental results on Microelectronic Center of North Carolina benchmark circuits
show that Binary Particle Swarm Optimization algorithm gives better convergence for the area
and wire length optimization than other algorithms.
Queering New Media Art : Histories & Asking Questions about Nothing
Authors: Rinehart Richard 
Published: October 2018

Not rooted in a traditional culture or ancestral homeland, Queerness constitutes ephemeral cultures, continually reinvented and reimagined. Queerness is under constant threat of erasure from cultural amnesia and political malice. Academia and the art world have responded to this erasure with alternately heroic and halting efforts.
This paper suggests ways in which this erasure manifests, from historic forces to contemporary discourses. The author attempts to assess various responses to queer erasure in the overlapping enclaves of new media art comprised of artists, academics, writers, and curators. Lastly, this paper will consider how new media art inflects or reframes ongoing conversations around queer social erasure and how artists and art historians work against the forces of nothingness.
Imitation, Fear, and Conviviality
Authors: Costa Pederson Claudia 
Published: October 2018

This essay discusses alternative models to mimesis as the norm in mainstream immersive technologies. Projects by two Latin American designers, the Uruguayan videogame designer Gonzalo Frasca, and the Cuban interaction designer, Iván Abreu Ochoa, exemplify such alternatives. I examine how both designers eschew idealized realism in favor of repositioning immersive spaces as a forum of debate about issues relevant to contemporary civic life, respectively, war and immigration. Conceived thusly, these works constitute uses of immersive technologies, gaming and the internet, for purposes of cultural critique and catalyzing emancipatory social energies. In this light, I argue that these projects work to both undermine normative conceptions of mimesis, as mimetic simulations are revealed to be partial, not neutral; and as well, demonstrate belief in the role of immersive technologies as support of convivial culture. As such, these projects are not unique, but can be understood as being part of transnational networks of alternative media, and extensions of the significant historical and contemporary contributions of Latin American artists and designers to this project.
ANALISIS FAKTOR-FAKTOR PENENTU KINERJA PROFITABILITAS BANK PERKREDITAN RAKYAT (BPR) KONVENSIONAL DI SUMATERA BARAT
Authors: Afriyeni Afriyeni , Fernos Jhon 
Published: October 2018

<p><em>The existence of Rural Banks (BPR) in assisting the development and economic progress of the community, especially in rural areas is very important. The purpose of this article is to examine and analyze the factors that determine the performance of the profitability of conventional rural banks in West Sumatra. To test the effect of each variable CAR, LDR, BOPO, and NPL on profitability (ROA) statistical methods and data processing are used with the SPSS program. The type of data used is secondary data obtained from Bank Indonesia, namely the conventional BPR Publication Report in West Sumatra in 2012-2016. The population in this study is conventional BPR in West Sumatra and the sample is taken by purposive sampling method, so that 85 observations are obtained. Data were analyzed using multiple linear regression. Based on the results of the study found that the internal factors of the bank CAR, LDR, BOPO and NPL have a significant effect on the profitability (ROA) of conventional BPR in West Sumatra.</em></p><p> </p><p>Keberadaan Bank Perkreditan Rakyat (BPR) dalam membantu perkembangan dan kemajuan ekonomi masyarakat terutama di wilayah pedesaaan sangat penting. Tujuan dari artikel ini adalah untuk menguji dan menganalisis faktor-faktor yang menjadi penentu kinerja profitabilitas BPR konvensional di Sumatera Barat (Sumbar). Untuk menguji pengaruh dari masing-masing variabel CAR, LDR, BOPO, dan NPL terhadap profitabilitas (ROA) digunakan metode statistik dan pengolahan data dengan program SPSS. Jenis data yang digunakan adalah data sekunder yang diperoleh dari Bank Indonesia yakni Laporan Publikasi BPR konvensional di Sumbar tahun 2012 – 2016. Populasi dalam penelitian ini BPR konvensional di Sumatera Barat dan pengambilan sampel dengan <em>purposive sampling method,</em> sehingga diperoleh sebanyak 85 pengamatan. Data dianalisis dengan menggunakan regresi linear berganda. Berdasarkan hasil penelitian ditemukan bahwa faktor-faktor internal bank CAR, LDR, BOPO dan NPL berpengaruh signifikan terhadap profitabilitas (ROA) BPR konvensional di Sumatera Barat.</p>
INDIKASI MACHIAVELLIANISM DALAM PEMBUATAN KEPUTUSAN ETIS AUDITOR PEMULA
Authors: Ananda Febryandhie , Zulvia Dewi 
Published: October 2018

<p><em>This research is a continuation from the previous research who find inconsistent results. The purpose of this study is to examine the machiavellianism relationship with ethical decisions in earnings management in Indonesia in two forms of manipulation, namely manipulation of operations and accounting manipulation. Data collection methods in this study used as many as 34 respondent. Machiavellianism does not affect the ethical decision of earnings management in the Public Accountant Office in West Sumatra. Independent accountants who support are those who have the majority of first-level education with an average age of 26-35 years, who are generally male and have more than 10 years of experience. This is because the customary system of ABS - SBK (Adat Bersandi Syara '- Syara' Bersandi Kitabullah) in West Sumatra has an impact on the machiavellian nature of accountants, and there is a significant difference between operating manipulation and accounting manipulation.</em></p><p> </p><p>Penelitian ini merupakan kelanjutan dari penelitian sebelumnya yang menemukan hasil yang tidak konsisten. Tujuan dari penelitian ini adalah untuk menguji hubungan machiavellianism dengan keputusan etis dalam manajemen laba di Indonesia dalam dua bentuk manipulasi, yaitu manipulasi operasi dan manipulasi akuntansi. Metode pengumpulan data dalam penelitian ini menggunakan sebanyak 34 responden. <em>Machiavellianism</em> tidak mempengaruhi keputusan etis manajemen laba di Kantor Akuntan Publik di Sumatera Barat. Akuntan independen yang mendukung adalah mereka yang memiliki mayoritas pendidikan tingkat pertama dengan usia rata-rata 26-35 tahun, yang umumnya laki-laki dan memiliki lebih dari 10 tahun pengalaman. Hal ini karena sistem adat ABS - SBK (Adat Bersandi Syara '- Syara' Bersandi Kitabullah) di Sumatera Barat memiliki dampak pada sifat machiavellian akuntan, dan ada perbedaan yang signifikan antara manipulasi operasi dan manipulasi akuntansi.</p>