bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-thrombotic Mechanisms of Echinochrome A on Arterial Thrombosis in Rats: In-Silico, In-Vitro and In-Vivo Studies
Authors: Khalaf Marina Lotfy , Soliman Amel Mahmoud , Fahmy Sohair Ramadan , Mohamed Ayman Saber 
Published: November 2024

Background:
Arterial thrombosis is one of the most significant healthcare concerns in
the world. Echinochrome A (Ech-A) is a natural quinone pigment isolated from sea urchins. It has
a variety of medicinal values associated with its antioxidant, anticancer, antiviral, anti-diabetic,
and cardio-protective activities.

Objective:
The current study aims to investigate the effect and mechanism of Ech-A to inhibit
thrombus formation induced by ferric chloride in rats.

Methods:
Twenty-four rats were assigned into four groups (n= 6); sham and thrombotic model
groups were orally administered 2% DMSO, while the other groups were treated with two dosages
of Ech-A (1 and 10 mg/kg, body weight). After seven days of administration, all groups were exposed
to 50% ferric chloride for 10 min, except the sham group exposure to normal saline.

Results:
The molecular docking showed the free binding energies of Ech-A and vitamin K (Vit.
K) with Vit. K epoxide reductase were -8.5 and -9.8 kcal/mol, which confirm the antithrombotic
activity of Ech-A. The oral administration of Ech-A caused a significant increase in partial thromboplastin
time, prothrombin time, clotting time, platelet count, fibrinogen levels, factor VIII, glutathione
reduced, catalase, nitric oxide, and glutathione S-transferase. While white blood cells
count, calcium level, and malondialdehyde concentration significantly decreased. The histological
examination revealed a definite improvement in the carotid and cardiac tissues in the Ech-A
groups.

Conclusion:
The study results showed that Ech-A prevented thrombosis by several mechanisms,
including chelating calcium ions, increasing the NO concentration, suppressing oxidative stress,
and antagonizing Vit. K.
Association between Volunteer Activity Participation and Daily Sedentary Time among Adults in Japan: A Cross-sectional Study
Authors: Ukawa Shigekazu , Kato Yusuke , Lee Yonggeun , Sugiyama Masaaki , Saito Hiroko , Ohara Kazuoki , Mori Kazuhiko 
Published: November 2024

Introduction
Sedentary behavior, involving low energy expenditure while sitting or reclining, is linked to health risks. Volunteering may help reduce sedentary time through social interaction and physical activity, but this relationship is understudied in non-Western contexts. This study investigated the association between volunteer activity frequency and daily sitting time among adults in Aichi and Kanagawa Prefectures, Japan, regions with higher aging.

Methods
A cross-sectional study was conducted in two regions of Japan, with a sample of 1,224 adults (585 men and 639 women) from these regions. Data on volunteer activity frequency and daily sitting time were collected using questionnaires. Multiple regression models explored the relationship between volunteer frequency and sitting time, adjusting for confounders.

Results
The mean daily sitting time was 357.66 ± 240.40 minutes. Participants volunteering four or more times weekly reported significantly shorter sitting times compared to non-participants, with an average difference of 131.96 minutes (95% CI: -253.83 to -10.08) in the multivariable-adjusted model. This association was stronger among males (difference: 180.51 minutes; 95% CI: -353.84 to -7.28) and older adults aged ≥65 years (difference of 142.48 minutes; 95% CI: -272.58 to -12.38).

Conclusion
Frequent volunteering is associated with shorter sitting times, particularly among males and older adults. However, due to the cross-sectional design, causal inferences cannot be made, and the associations should be interpreted with caution. Compared to Western populations, sitting time was lower, but it still exceeded public health recommendations. Future research should explore the longitudinal effects and identify specific volunteer activities that promote active lifestyles.
Kabata Banda & the significance of Islamic eco-theology education
Authors: Latuapo Abdullah , Farid Muhammad 
Published: November 2024

The environmental crisis is a real threat to human survival. Climate change, natural disasters, and food crises are some of the devastating impacts that can have a major impact on the human population. The Banda Islands have a wide water zone with diverse marine biota but face the threat of natural disasters from active volcanoes and human behaviour that is not environmentally friendly. Historically, Banda has a tradition that is very close to coastal nature. This is revealed in their traditional song known as Kabata Belang, often sung while rowing a traditional boat (Belang) in various community cultural stages. By adopting phenomenology perspectives, this research is focused on reviewing the narration of the Fiat’ Kabata belang sacrament songs to seek out the implied values of environmental ethics and its urgency in handling coastal environmental problems in Banda Naira today. The results show that Kabata Belang contains both theological and ecological values (eco-theology) apart from being an instrument of traditional rituals. There are 13 stanzas in Fiat village Kabata Belang that are oriented towards maintaining several coastal natural objects, such as mountains, coasts, birds, and fish. The singing of the Kabata Belang as a traditional wisdom functions as an "advisor" for the people of Banda today to preserve the marine and coastal environment. This research recommends the importance of writing down the Kabata text, complete with pictures and articulations that are more accessible to the public as a guidebook, especially for the younger generation to understand better and participate in creative efforts to preserve the coastal and marine environment in their everyday lives.
Speak Up: Stepping up "show and tell" to enhance EFL students' speaking and communication skills
Authors: Betaubun Martha , Rokhmah Desy Eva laila 
Published: November 2024

As the world has shifted dramatically, university graduates must possess hard and soft skills to compete in the job market and thrive in the competitive era of 5.0. Strong communication skills, encompassing speaking, listening, observing, and empathizing, are essential for success in this competitive environment. This paper aims to elaborate on implementing a simple classroom activity called "Show and Tell" to encourage students to communicate freely. The show-and-tell activity was modified to meet the needs of university-level students. The study involved 120 students from the civil engineering, law, and architecture departments of Musamus University of Merauke, with 53 female and 67 male students. This research utilized a qualitative approach to understand the learners' development better. The data collection methods in the field included field notes, audio-video recordings, and interviews with the learners. The results indicate that while students' English competencies were generally at a beginner level, the "show and tell" activity significantly enhanced their confidence and communication skills. Participants reported feeling more at ease when speaking in front of their peers, leading to improved articulation and organization of thoughts. Simultaneously, the activity also fostered empathy and a supportive learning environment, as students connected emotionally with their classmates.
Real-Time Analytics and AI for Managing No-Show Appointments in Primary Health Care in the United Arab Emirates: Before-and-After Study
Authors: AlSerkal Yousif Mohamed , Ibrahim Naseem Mohamed , Alsereidi Aisha Suhail , Ibrahim Mubaraka , Kurakula Sudheer , Naqvi Sadaf Ahsan , Khan Yasir , Oottumadathil Neema Preman 
Published: November 2024

Abstract

Background
Primary health care (PHC) services face operational challenges due to high patient volumes, leading to complex management needs. Patients access services through booked appointments and walk-in visits, with walk-in visits often facing longer waiting times. No-show appointments are significant contributors to inefficiency in PHC operations, which can lead to an estimated 3%-14% revenue loss, disrupt resource allocation, and negatively impact health care quality. Emirates Health Services (EHS) PHC centers handle over 140,000 visits monthly. Baseline data indicate a 21% no-show rate and an average patient wait time exceeding 16 minutes, necessitating an advanced scheduling and resource management system to enhance patient experiences and operational efficiency.

Objective
The objective of this study was to evaluate the impact of an artificial intelligence (AI)-driven solution that was integrated with an interactive real-time data dashboard on reducing no-show appointments and improving patient waiting times at the EHS PHCs.

Methods
This study introduced an innovative AI-based data application to enhance PHC efficiency. Leveraging our electronic health record system, we deployed an AI model with an 86% accuracy rate to predict no-shows by analyzing historical data and categorizing appointments based on no-show risk. The model was integrated with a real-time dashboard to monitor patient journeys and wait times. Clinic coordinators used the dashboard to proactively manage high-risk appointments and optimize resource allocation. The intervention was assessed through a before-and-after comparison of PHC appointment dynamics and wait times, analyzing data from 135,393 appointments (67,429 before implementation and 67,964 after implementation).

Results
Implementation of the AI-powered no-show prediction model resulted in a significant 50.7% reduction in no-show rates (P<.001). The odds ratio for no-shows after implementation was 0.43 (95% CI 0.42-0.45; P<.001), indicating a 57% reduction in the likelihood of no-shows. Additionally, patient wait times decreased by an average of 5.7 minutes overall (P<.001), with some PHCs achieving up to a 50% reduction in wait times.

Conclusions
This project demonstrates that integrating AI with a data analytics platform and an electronic health record systems can significantly improve operational efficiency and patient satisfaction in PHC settings. The AI model enabled daily assessments of wait times and allowed for real-time adjustments, such as reallocating patients to different clinicians, thus reducing wait times and optimizing resource use. These findings illustrate the transformative potential of AI and real-time data analytics in health care delivery.
Use of Aspirin and Initial Cardiovascular and Bleeding Risk in Patients with Chronic Kidney Disease
Authors: Kim Jae Young , Lim Hyunsun , Park Cheol Ho , Kim Hyung Woo , Chang Tae Ik , Han Seung Hyeok 
Published: November 2024

Background:
Despite the high cardiovascular risk in patients with chronic kidney disease (CKD), the role of aspirin in primary prevention remains unclear. This study aimed to investigate the association between aspirin initiation in adults with CKD without prior cardiovascular disease (CVD) and the first cardiovascular and bleeding events using Korean nationwide cohort data.

Methods:
Among individuals aged 40–79 years with an estimated glomerular filtration rate between 15 and 59 mL/min/1.73 m2 who underwent routine health examinations between 2011 and 2016, 15,861 individuals who were newly prescribed aspirin at a dose of 100 mg/day were matched with 79,305 aspirin non-users by propensity score matching. The primary efficacy outcome was a composite of nonfatal atherosclerotic CVD or cardiovascular death. The primary safety outcome was hospitalization due to intracranial or gastrointestinal bleeding.

Results:
During a mean follow-up of 6.9±2.9 years, the incidence rates for the primary efficacy outcome in aspirin users and non-users were 8.0 and 9.0 per 1,000 person-years, respectively. Aspirin therapy initiation was not associated with the primary efficacy outcome (hazard ratio [HR], 0.93; 95% confidence intervals [CI], 0.86-1.04). However, the primary safety outcome of major bleeding was more frequent in aspirin users than in non-users (6.7 versus 4.7 per 1,000 person-years). The HR for this outcome in aspirin users versus non-users was 1.45 (95% CI, 1.32-1.59).

Conclusions:
No association was observed between aspirin use and the risk of nonfatal atherosclerotic CVD or cardiovascular death in patients with CKD stages G3 and G4 without prior CVD. Aspirin use was associated with higher risk of major bleeding.
Karakteristik Fisikokimia Snack Bar Berbasis Tepung Ubi Jalar Ungu dan Tepung Kacang Merah
Authors: Arifanti Ananta Pitaloka , Damat Damat , Siskawardani Devi Dwi 
Published: November 2024

Snack bar merupakan makanan berbentuk batangan yang terbuat dari gabungan berbagai bahan makanan, seperti buah-buahan, serealia, kacang-kacangan, buah-buahan, dan sayuran. Snack bar merupakan produk sehat mengandung gizi seimbang yang didesain sebagai camilan yang dapat dikonsumsi setiap saat. Penelitian ini bertujuan untuk mengkaji karakteristik fisikokimia snack bar dengan perbandingan tepung ubi jalar ungu dan tepung kacang merah. Metode penelitian yang digunakan yaitu Rancangan Acak Lengkap (RAL) satu faktor. Formulasi tepung ubi jalar ungu dan tepung kacang merah meliputi P1(90:10), P2(80:20), P3(70:30), P4(60:40), P5(50:50). Analisis fisikokimia yang dihasilkan dari snack bar tepung ubi jalar ungu dan tepung kacang merah pada analisis fisik snack bar yaitu intensitas warna dengan nilai L sebesar 43,20 – 49,16, nilai a sebesar 8,46 – 10,26, nilai b sebesar 5,16 – 9,83 dan tekstur sebesar 14,69 N – 25,66 N. Analisis kimia pada Snack bar yaitu, kadar air sebesar 3,99% – 4,28%, kadar lemak sebesar 12,9%– 13,52%, kadar protein sebesar 4,59% – 7,52%, kadar serat sebesar 15,34% – 17,1%, dan aktivitas antioksidan sebesar 86,67% – 88,67%. Formulasi terbaik yang didapatkan dari penelitian ini adalah perlakuan tepung ubi jalar ungu dan tepung kacang merah P1 (90:10) dengan kadar air sebesar 4,28% kadar lemak sebesar 12.93%, kadar protein sebesar 4,59%, kadar serat pangan sebesar 17,1%, aktivitas antioksidan sebesar 88,67%, intensitas warna nilai L sebesar 43,20, nilai a sebesar 8,46, nilai b sebesar 5,16, dan tekstur sebesar 14,69 N.
A representação feminina na literatura contemporânea: um estudo do romance Inferno, de Patrícia Melo
Authors: Carneiro Ana Paula Lima 
Published: November 2024

Na presente pesquisa, buscamos conhecer aspectos ligados à representação da mulher na literatura contemporânea de autoria feminina, a partir do romance Inferno, publicado em 2000, escrito por Patrícia Melo. Focalizamos nas ações praticadas pela personagem Marta, uma mulher que não mede esforços para se tornar líder do tráfico de drogas no morro do Berimbau, localizado no Rio de Janeiro. A pesquisa foi realizada com base em um aporte metodológico de cunho bibliográfico, de base sociológica, especificamente centrada nas concepções de Antonio Candido (2006; 2010), e na teoria feminista, com base nas seguintes autoras: Koss (2000), Zolin (2009), Beauvoir (2016), dentre outras. Após a realização da pesquisa podemos inferir que a personagem Marta é fruto da sociedade contemporânea, confirmando a estreita relação entre literatura e sociedade, pois é uma mulher que assume responsabilidade de mando, questionando certas imposições sociais.
Transformações no modo de produzir, publicar e consumir revistas
Authors: Oliveira Fernanda Redin , Tassinari Maria Tereza Dias , Depexe Sandra 
Published: November 2024

O presente artigo possui como objetivo estudar as diferentes formas de produção e publicação de uma revista a fim de verificar a viabilidade de uma publicação exclusiva no Instagram. Debruçando-se sobre as teorias de Ali (2009), Scalzo (2011), Benetti (2013), Caldwell e Zappaterra (2014), Dourado (2013), conceitua o que é revista, suas principais características, apresenta as mudanças do impresso para o digital, os principais suportes de publicação, além de mapear as ferramentas da rede social Instagram e as revistas já publicadas utilizando a plataforma. Por fim, conclui-se que uma revista publicada inteiramente no Instagram mantém as características originais deste tipo de publicação, desta forma pode se considerar uma revista digital nativa da plataforma.

Palavras-chave: Revista digital. Redes sociais. Instagram.
Do YouTube para a TV: mediações e (meta)crítica em Choque de Cultura
Authors: Silva Renan Honorato Gomes da , Scabin Nara Lya Cabral 
Published: November 2024

O artigo tem como objetivo analisar as múltiplas “camadas” de sentido presentes no programa humorístico Choque de Cultura (TV Quase) à luz de diferentes “momentos” do circuito da comunicação, considerando, para isso, suas temporadas exibidas pela TV Globo. O percurso metodológico/analítico do trabalho considera os seguintes aspectos: possibilidades de codificação/decodificação à luz de teorias do humor; perspectivas sobre os processos de codificação a partir de manifestações do lugar de produção; aspectos da circulação do programa Choque de Cultura na cultura midiática; e dimensão das mediações das discursividades engendradas em Choque de Cultura. Como principais resultados da pesquisa, chamamos a atenção para o recurso à incongruidade como principal estratégia de produção de humor no programa em foco, bem como à presença de elementos de metacriticidade nos episódios analisados, que mobilizam narrativas e sentidos circulantes na própria cultura midiática.
Análise visual da construção de mensagens imagéticas em posts do perfil do Governo de Pernambuco no Instagram durante a Pandemia da Covid-19
Authors: Silva Bianca Gabriely Ferreira , Silva Mary Dayane Souza , Silva Tamires Maria de Lima , Silva Geymeesson Brito da 
Published: November 2024

A presente pesquisa objetiva analisar a escolha e aplicação dos elementos visuais em posts do perfil do Instagram do Governo do Estado de Pernambuco direcionados a campanha de enfrentamento da Covid-19. Para tanto, foram selecionados posts veiculados no Instagram do Governo do Estado de Pernambuco @governope, no período de 2020 a 2022. A partir da seleção dos posts, trata-se de um estudo qualitativo, do tipo pesquisa por imagem. Na fase analítica, utilizou-se os princípios de análise da imagem apresentados em Joly (1996), bem como os referenciais dos fundamentos da composição e sintaxe visual, expostos por Dondis (1997). Com relação aos resultados, entende-se que as redes sociais são mecanismos efetivos para levar informações corretas e úteis a população, sendo pertinentes durante o período da pandemia de Covid-19.
Entendeu ou quer que descomplique? Noções verticais de ensino na plataforma digital Descomplica
Authors: Silva Igor Fonseca , Santos Inara da Silva , Pessoa Isabela Logrado Fanaia , Almeida Verbena Córdula 
Published: November 2024

Este trabalho apresenta uma reflexão acerca da plataforma de ensino virtual Descomplica, tendo como foco o seu princípio pedagógico. O objetivo principal é observar se o modelo de “educação bancária” descrito por Freire (1987) está inserido como prática pedagógica no canal. As análises se baseiam em três videoaulas das áreas de História, Sociologia e Filosofia, disponibilizadas gratuitamente no YouTube. O estudo está ancorado em teóricos como Paulo Freire (1987/1996), Kaplún (1998), Barros (2011), Citelli (2018) e outros, que discutem acerca da educação crítica e horizontal, do entrelace entre Comunicação e Educação, da Educação em tempos de tecnologia, entre outros. Foi possível observar que didática utilizada pela plataforma possui abordagens educacionais pautadas em uma lógica estrutural liberal, na qual a promoção de conhecimento é a última prioridade.
Jogos: contexto capacitante para o desenvolvimento sustentável
Authors: Soto Maria das Graças Rojas , Silva Maclóvia Correa da 
Published: November 2024

Conhecimentos e escolhas voltados ao desenvolvimento sustentável podem ser fomentados no processo educativo de maneira lúdica. O objetivo deste estudo foi identificar as contribuições dos jogos para a educação ambiental, como contextos capacitantes para o compartilhamento de conhecimento e estímulo a comportamentos sustentáveis. Foi realizada uma revisão sistemática de literatura e os resultados obtidos foram analisados à luz dos estudos sobre “Ba”, ou espaços para compartilhamento de conhecimento. Os jogos são considerados instrumentos efetivos para o desenvolvimento de habilidades colaborativas que coincidem com os objetivos de proteção ambiental, engajam jogadores nos processos de aprendizagem e criação de conhecimento e podem conduzir a mudança de modelos mentais, contribuindo com a educação. Desta forma, os jogos podem ser compreendidos como espaços colaborativos nos quais emerge o processo de criação de conhecimento, capaz de fomentar reflexões e atitudes sustentáveis.
O uso das aspas na construção do ethos discursivo em Lélia Gonzalez e Rita Lee: uma estratégia argumentativa
Authors: Civiero Lohana Larissa Mariano , Silva Renan Fabrício Lorenzatto da 
Published: November 2024

Esta pesquisa busca analisar o uso das aspas como recurso argumentativo na construção do ethos discursivo de duas personalidades distintas, Lélia Gonzalez e Rita Lee. Autoras que, apesar de atuarem em campos diferentes, compartilham paralelos peculiares de formas de expressão e engajamento social. Por meio de recortes da primeira parte da obra Lugar de negro (1982), escrita por Gonzalez, e da obra Rita Lee: uma autobiografia, (2016), de Rita Lee, e com embasamento teórico em autores como Perelman e Olbrechts-Tyteca (2002), Authier-Revuz (1990; 2004), Amossy (2008) entre outros, busca-se a análise das estratégias argumentativas utilizadas pelas autoras a partir da construção do ethos discursivo. Concluiu-se que as autoras utilizam as aspas na construção do ethos discursivo ao reforçar a credibilidade e autenticidade das narrativas apresentadas.
As políticas de comunicação nas universidades federais do Nordeste e os desafios da Comunicação Pública
Authors: Reis Caroline Brito dos 
Published: November 2024

O trabalho tem o objetivo de estudar as Políticas de Comunicação das universidades federais dos nove estados do Nordeste a fim de analisar se elas dispõem sobre Comunicação Pública para entender se nesses documentos existe uma priorização da questão da transparência institucional e da publicização das ações públicas. Para isso, utilizou como metodologia a Análise de Conteúdo (AC). A conclusão é que não existe uma uniformidade na extensão das Políticas de Comunicação e nem todas elas mencionam a Comunicação Pública embora se pautem por questões como transparência, acessibilidade e diálogo com os públicos interno e externo. Também são poucas as instituições que contam com políticas.