bluuebunny/crossref_metadata_2025_split huggingface dataset:
New short-term heat inactivation method of cytomegalovirus (CMV) in breast milk: impact on CMV inactivation, CMV antibodies and enzyme activities
Authors: Maschmann Jens , Müller Denise , Lazar Katrin , Goelz Rangmar , Hamprecht Klaus 
Published: February 2019

ObjectivesBreast milk (BM) is the primary source of cytomegalovirus (CMV) transmission to premature infants with potentially harmful consequences. We therefore wanted to evaluate temperature and duration of short-term BM pasteurisation with respect to CMV inactivation, effect on CMV-IgG antibodies and BM enzyme activities.Methods116 artificially CMV-spiked BM and 15 wild-type virus-infected samples were subjected for 5 s to different temperatures (55°C–72°C). CMV-IE-1 expression in fibroblast nuclei was assessed using the milk whey fraction in short-term microculture. BM lipase and alkaline phosphatase (AP) activities and CMV binding using CMV-recomLine immunoblotting and neutralising antibodies using epithelial target cells were analysed before and after heating.ResultsA minimum of 5 s above 60°C was necessary for CMV inactivation in both CMV-AD-169 spiked and wild-type infected BM. Lipase was very heat sensitive (activities of 54% at 55°C, 5% at 60°C and 2% at 65°C). AP showed activities of 77%, 88% and 10%, respectively. CMV-p150 IgG antibodies were mostly preserved at 62°C for 5 s.ConclusionOur results show that short-term pasteurisation of BM at 62°C for 5 s might be efficient for CMV inactivation and reduces loss of enzyme activities, as well as CMV binding, and functional CMV antibodies.
Aerobic exercise alleviates depressive symptoms in patients with a major non-communicable chronic disease: a systematic review and meta-analysis
Authors: Béland Mélanie , Lavoie Kim L , Briand Samantha , White Una J , Gemme Claudia , Bacon Simon L 
Published: February 2019

Objective
To assess whether aerobic exercise was superior to usual care in alleviating depressive symptoms in patients living with a major non-communicable disease.

Data sources
Data were obtained from online databases (PubMed, PsycINFO and SPORTDiscus) as well as from reference lists. The search and collection of eligible studies was conducted up to 18 October 2018 (PROSPERO registration number CRD42017069089).

Study selection
We included interventions that compared aerobic exercise with usual care in adults who reported depressive symptoms (ie, not necessarily the clinical diagnosis of depression) and were living with a major non-communicable disease.

Results
Twenty-four studies were included in the meta-analysis (4111 patients). Aerobic exercise alleviated depressive symptoms better than did usual care (standardised mean difference (SMD)=0.50; 95% CI 0.25 to 0.76; Grading of Recommendations Assessment, Development and Evaluation: low quality). Aerobic exercise was particularly effective in alleviating depressive symptoms in cardiac patients (SMD=0.67; 95% CI 0.35 to 0.99).

Conclusion
Aerobic exercise alleviated depressive symptoms in patients living with a major non-communicable disease, particularly in cardiac populations. Whether aerobic exercise treats clinically diagnosed depression was outside the scope of this study.
Dietary intervention in patients with age-related macular degeneration: protocol for a randomised controlled trial
Authors: Tang Diana , Mitchell Paul , Flood Victoria , Kifley Annette , Hayes Alison , Liew Gerald , Gopinath Bamini 
Published: February 2019

IntroductionAge-related macular degeneration (AMD) is a leading cause of blindness. After smoking, nutrition is the key modifiable factor in reducing AMD incidence and progression, and no other preventative treatments are currently available. At present, there is an evidence–practice gap of dietary recommendations made by eye care practitioners and those actually practised by patients with AMD. To address this gap, a telephone-delivered dietary intervention tailored to patients with AMD will be piloted. The study aims to improve dietary intake and behaviours in patients with AMD. This type of nutrition-focused healthcare is currently not considered in the long-term management of AMD and represents the first empirical evaluation of a telephone-supported application encouraging adherence to dietary recommendations for AMD.Methods and analysis140 participants with AMD will be recruited for this randomised controlled trial. Those lacking English fluency; unwilling to engage in the intervention or provide informed consent were excluded. Following the completion of the baseline questionnaire, participants will be randomised into one of two arms: intervention or wait-list control (70 each in the intervention and control groups). Intervention participants will receive a detailed mail-delivered workbook containing information on healthy eating behaviours that promote optimal macular health, as well as scheduled phone calls over 4 months from an accredited practising dietitian. Descriptive statistics and multivariate stepwise linear regressions analyses will be used to summarise and determine the changes in dietary intakes, respectively. Economic analysis will be conducted to determine intervention feasibility and possibility of a large-scale rollout.Ethics and disseminationThe study was approved by the University of Sydney Human Research Ethics Committee (HREC) (Reference: HREC 2018/219). Study findings will be disseminated via presentations at national/international conferences and peer-reviewed journal articles.Trial registration numberACTRN12618000527268; Pre-results.
Long-term psychosocial impact of venous thromboembolism: a qualitative study in the community
Authors: Hunter Rachael , Noble Simon , Lewis Sarah , Bennett Paul 
Published: February 2019

ObjectivesVenous thromboembolism (VTE) is a serious, potentially traumatic, life-threatening condition and a major cause of mortality and morbidity. The aim of this study was to obtain detailed understandings of the impact of VTE and examine individual’s experiences over the first year since a first-time VTE.DesignA longitudinal qualitative interview study using inductive thematic analysis. This study presents follow-up data for 11 participants, first interviewed 6 months following a first-time VTE.SettingOutpatients recruited from a community haematology clinic in a UK District General Hospital.ParticipantsEleven participants (seven females and four males) recruited from a community haematology clinic. Participants had experienced a first-time VTE and participated in qualitative interviews 3 months previously.InterventionAudio-recorded semistructured interviews with a sample of 11 participants who experienced a first-time deep vein thrombosis or pulmonary embolism within the previous year. Interviews were transcribed and analysed using inductive thematic analysis.ResultsFour overarching themes were identified: life changing and forever changed, the trauma of care, ‘thrombo-neuroses’ and through adversity comes growth. Theme content varied according to age and developmental stage, presence of VTE symptoms and the experience of diagnosis.ConclusionsThe data demonstrate the psychosocial impact of VTE and its diagnosis as physically and psychologically challenging, and individuals reported being forever changed by the experience. Participants’ reported continued high levels of trauma and anxiety symptoms, triggered by physical (eg, symptoms) and psychological (eg, health anxiety, negative emotions) reminders of VTE. Wider primary care service issues including misdiagnosis maintained negative emotions and health anxiety with implications for relationships with professionals. Targeted clinical interventions to better identify and support individuals at risk of distress and enhance psychological well-being and reduce distress are discussed.
Effect of different financial competing interest statements on readers’ perceptions of clinical educational articles: a randomised controlled trial
Authors: Schroter Sara , Pakpoor Julia , Morris Julie , Chew Mabel , Godlee Fiona 
Published: February 2019

ObjectivesTo investigate how different competing interest (COI) statements affect clinical readers’ perceptions of education articles.DesignRandomised controlled trial.Setting and participantsRandom sample of UK doctors.InterventionsWe created four permutations of each of two clinical reviews (on gout or dyspepsia), which varied only in terms of the COI statement. Volunteers were blinded and randomised to receive one review and asked to complete a questionnaire after reading it. Blinded factorial analyses of variance and analyses of covariance were carried out to assess the influence of each review and type of COI on outcomes.Primary and secondary outcomesConfidence in the article’s conclusions (primary outcome), its importance, their level of interest in the article and their likelihood to change practice after reading it.ResultsOf 10 889 doctors invited to participate, 1065 (10%) volunteered. Of these, 749 (70%) completed the survey. Analysis of covariance (adjusting for age, sex, job type, years since qualification) showed no significant difference between the groups in participants’ confidence in the article (gout: p=0.32, dyspepsia: p=0.78) or their rating of its importance (gout: p=0.09, dyspepsia: p=0.79). For the gout review, participants rated articles with advisory board and consultancies COI as significantly less interesting than those with no COI (p=0.028 with Bonferroni correction). Among participants indicating that they treat the condition and that the article’s recommendations differed from their own practice, there was no significant difference in likelihood to change practice between groups (gout: p=0.59, n=59; dyspepsia: p=0.56, n=80).ConclusionsDoctors’ confidence in educational articles was not influenced by the COI statements. Further work is required to determine if doctors do not perceive these COIs as important in educational articles or if they do not pay attention to these statements. More meaningful COI disclosure practices may be needed, which highlight context-specific potential sources of bias to readers.Trial registration numberNCT02548312; Results.
Chronic heart failure patients’ experiences of German healthcare services: a protocol for a scoping review
Authors: Dieckelmann Mirjam , Reinhardt Felix , Jeitler Klaus , Semlitsch Thomas , Plath Jasper , Gerlach Ferdinand M , Siebenhofer Andrea , Petersen Juliana J 
Published: February 2019

IntroductionChronic heart failure (CHF) is a heterogeneous condition requiring complex treatment from diverse healthcare services. An increasingly holistic understanding of healthcare has resulted in contextual factors such as perceived quality of care, as well as patients’ acceptance, preferences and subjective expectations of health services, all gaining in importance. How patients with CHF experience the use of healthcare services has not been studied within the scope of a systematic review in a German healthcare context. The aim of this scoping review is therefore to review systematically the experiences of patients affected by CHF with healthcare services in Germany in the literature and to map the research foci. Further objectives are to identify gaps in evidence, develop further research questions and to inform decision makers concerned with improving healthcare of patients living with CHF.Methods and analysisThis scoping review will be based on a broad search strategy involving systematic and comprehensive electronic database searches in MEDLINE, EMBASE, PsycINFO, PSYNDEX, CINAHL and Cochrane’s Database of Systematic Reviews, grey literature searches, as well as hand searches through reference lists and non-indexed key journals. The methodological procedure will be based on an established six-stage framework for conducting scoping reviews that includes two independent reviewers. Data will be systematically extracted, qualitatively and quantitatively analysed and summarised both narratively and visually. To ensure the research questions and extracted information are meaningful, a patient representative will be involved.Ethics and disseminationEthical approval will not be required to conduct this review. Results will be disseminated through a clearly illustrated report that will be part of a wider research project. Furthermore, it is intended that the review’s findings should be made available to relevant stakeholders through conference presentations and publication in peer-reviewed journals (knowledge transfer). Protocol registration in PROSPERO is not applicable for scoping reviews.
Do doctors in dispensing practices with a financial conflict of interest prescribe more expensive drugs? A cross-sectional analysis of English primary care prescribing data
Authors: Goldacre Ben , Reynolds Carl , Powell-Smith Anna , Walker Alex J , Yates Tom A , Croker Richard , Smeeth Liam 
Published: February 2019

ObjectivesApproximately one in eight practices in primary care in England are ‘dispensing practices’ with an in-house dispensary providing medication directly to patients. These practices can generate additional income by negotiating lower prices on higher cost drugs, while being reimbursed at a standard rate. They, therefore, have a potential financial conflict of interest around prescribing choices. We aimed to determine whether dispensing practices are more likely to prescribe high-cost options for four commonly prescribed classes of drug where there is no evidence of superiority for high-cost options.DesignA list was generated of drugs with high acquisition costs that were no more clinically effective than those with the lowest acquisition costs, for all four classes of drug examined. Data were obtained prescribing of statins, proton pump inhibitors (PPIs), angiotensin receptor blockers (ARBs) and ACE inhibitors (ACEis). Logistic regression was used to calculate ORs for prescribing high-cost options in dispensing practices, adjusting for Index of Multiple Deprivation score, practice list size and the number of doctors at each practice.SettingEnglish primary care.ParticipantsAll general practices in England.Main outcome measuresMean cost per dose was calculated separately for dispensing and non-dispensing practices. Dispensing practices can vary in the number of patients they dispense to; we, therefore, additionally compared practices with no dispensing patients, low, medium and high proportions of dispensing patients. Total cost savings were modelled by applying the mean cost per dose from non-dispensing practices to the number of doses prescribed in dispensing practices.ResultsDispensing practices were more likely to prescribe high-cost drugs across all classes: statins adjusted OR 1.51 (95% CI 1.49 to 1.53, p<0.0001), PPIs OR 1.11 (95% CI 1.09 to 1.13, p<0.0001), ACEi OR 2.58 (95% CI 2.46 to 2.70, p<0.0001), ARB OR 5.11 (95% CI 5.02 to 5.20, p<0.0001). Mean cost per dose in pence was higher in dispensing practices (statins 7.44 vs 6.27, PPIs 5.57 vs 5.46, ACEi 4.30 vs 4.24, ARB 11.09 vs 8.19). For all drug classes, the more dispensing patients a practice had, the more likely it was to issue a prescription for a high-cost option. Total cost savings in England available from all four classes are £628 875 per month or £7 546 502 per year.ConclusionsDoctors in dispensing practices are more likely to prescribe higher cost drugs. This is the largest study ever conducted on dispensing practices, and the first contemporary research suggesting some UK doctors respond to a financial conflict of interest in treatment decisions. The reimbursement system for dispensing practices may generate unintended consequences. Robust routine audit of practices prescribing higher volumes of unnecessarily expensive drugs may help reduce costs.
Social determinants of health among residential areas with a high tuberculosis incidence in a remote Inuit community
Authors: Kilabuk Elaine , Momoli Franco , Mallick Ranjeeta , Van Dyk Deborah , Pease Christopher , Zwerling Alice , Potvin Sharon Edmunds , Alvarez Gonzalo G 
Published: February 2019

BackgroundTuberculosis (TB) remains a significant health burden among Inuit in Canada. Social determinants of health (SDH) play a key role in TB infection, disease and ongoing transmission in this population. The objective of this research was to estimate the prevalence of social determinants of Inuit health as they relate to latent TB infection (LTBI) among people living in residential areas at high risk for TB in Iqaluit, Nunavut.MethodsInperson home surveys were conducted among those who lived in predetermined residential areas at high risk for TB identified in a door-to-door TB prevention campaign in Iqaluit, Nunavut in 2011. Risk ratios for SDH and LTBI were estimated, and multiple imputation was used to address missing data.Results261 participants completed the questionnaire. Most participants identified as Inuit (82%). Unadjusted risk ratios demonstrated that age, education, smoking tobacco, crowded housing conditions and Inuit ethnicity were associated with LTBI. After adjusting for other SDH, multivariable analysis showed an association between LTBI with increasing age (relative risk, RR 1.07, 95% CI 1.04 to 1.11), crowded housing (RR 1.48, 95% CI 1.10 to 2.00) and ethnicity (RR 2.76, 95% CI 1.33 to 5.73) after imputing missing data.ConclusionAmong high-risk residential areas for TB in a remote Arctic region of Canada, crowded housing and Inuit ethnicity were associated with LTBI after adjusting for other SDH. In addition to strong screening and treatment programmes, alleviating the chronic housing shortage will be a key element in the elimination of TB in the Canadian Inuit Nunangat.
Empowering podiatrists to perform pulse checks for opportunistic atrial fibrillation detection during annual diabetes foot checks
Authors: Hicks Linda , Newton Julia , Nayar Rahul , Mackay Kate 
Published: February 2019

ObjectiveTo determine whether training podiatrists to provide opportunistic screening for atrial fibrillation (AF) during the local diabetes foot check was feasible and whether it detects previously unknown AF.MethodDuring the initiative, 45 podiatrists from across North Durham, Darlington and Durham Dales Easington and Sedgefield Clinical Commissioning Groups were trained to recognise heart irregularities when taking pulse readings of feet of patients with diabetes during their annual foot screening reviews.ResultsOver the course of the 3-month pilot, 5000 patients with diabetes had their feet pulse-tested. The project uncovered that for every 500 patients who had their feet checked, one new case of AF could be identified.ConclusionA report following the Podiatry and Atrial Fibrillation Case Finding scheme revealed that the National Health Service in the United Kingdom North East and North Cumbria area could benefit from potential cost savings in excess of £500 000. In 2013, the National Diabetes Information Service, Yorkshire and Humber Public Health Observatory estimated 231 777 people in the North East, North Cumbria, Hambleton and Richmondshire area with diabetes. Therefore 463 patients could be found with AF, preventing 23 strokes and saving £539 742 or in excess of £0.5 M.
Myrmekitic intergrowth of tourmaline and quartz in eclogite-hosting gneisses of the Tso Morari ultrahigh-pressure metamorphic terrane (Eastern Ladakh, India): a possible record of high-pressure conditions
Authors: Broska Igor , Bačík Peter , Kumar Santosh , Janák Marian , Kurylo Sergiy , Filip Jan , Bazarnik Jakub , Mikuš Tomáš 
Published: February 2019

Abstract

Alkaline schorlitic tourmaline with domains of myrmekitic quartz and tourmaline intergrowths is reported for the first time from quartzo-feldspathic gneisses of the Tso Morari Crystalline Complex (TMCC), eastern Ladakh Himalaya. Except for schorlitic tourmaline, the brown-green dravitic tourmaline occurs in melanocratic layers of the gneiss. The schorlitic tourmaline contains REE-rich apatite, which is a typical mineral formed under high-pressure (HP) conditions. The observed myrmekite, marked by vermicular quartz and tourmaline intergrowths, was probably formed during decompression as a consequence of excess silica released from recrystallized tourmaline. The recalculated composition of the tourmaline with quartz myrmekite suggests that Si also occupied the tourmaline octahedral
Z
site during the HP regime. During decompression excess Si from this tourmaline was replaced by Mg and Fe
3+
. At an early stage of exhumation needle-shaped schorlitic tourmaline II and mosaic zoning were formed. The excess of silica and the structural disorder suggest that the Si-oversaturated tourmaline was stable at high-pressure–ultrahigh-pressure (HP–UHP) conditions. The greater stability of dravitic tourmaline compared to schorlitic tourmaline at HP conditions is evidently recorded at the TMCC. The tourmaline-bearing gneisses of the TMCC most probably shared the same metamorphic conditions during Tertiary collision of the Indian and Eurasian plates, similar to that observed for the associated UHP eclogites.
Granites and crustal heat budget
Authors: Moyen Jean-François 
Published: February 2019

Abstract
The origin of large I-type batholiths remains a disputed topic. One model states that I-type granites form by partial melting of older crustal lithologies (amphibolites or intermediate igneous rocks). In another view, granites are trapped rhyolitic liquids occurring at the end of fractionation trends defining a basalt–andesite–dacite–rhyolite series. This paper explores the thermal implications of both scenarios, using a heat balance model that abstracts the heat production and consumption during crustal melting. Heat is consumed by melting and by losses through the surface (conductive or advective, as a result of eruption). It is supplied as a basal conductive heat flux, as internal heat production or as advective heat carried by an influx of hot basalt into the crust. Using this abstract approach, it is possible to explore the role different parameters play in the balance of granites formed by differentiation of basalts or by crustal melting. Two end-member situations appear equally favourable to generating large volumes of granites: (1) short-lived environments dominated by high basaltic flux, where granites result mostly from basalt differentiation; and (2) long-lived systems with no or minimal basalt flux, with granites resulting chiefly from crustal melting.
Performing process-oriented investigations involving mass transfer using Rcrust: a new phase equilibrium modelling tool
Authors: Mayne Matthew Jason , Stevens Gary , Moyen Jean-François , Johnson Tim 
Published: February 2019

Abstract
Modern quantitative phase equilibria modelling allows the calculation of the stable phase assemblage of a rock system given its pressure, temperature and bulk composition. A new software tool (Rcrust) has been developed that allows the modelling of points in pressure–temperature–bulk composition space in which bulk compositional changes can be passed from point to point as the system evolves. This new methodology enables quantitative process-oriented investigation of the evolution of rocks. Procedures are outlined here for using this tool to model: (1) the control of the water content of a subsolidus system based on available pore space; (2) the triggering of melt loss events when a critical melt volume threshold is exceeded, while allowing a portion of melt retention; (3) the entrainment of crystals during segregation and ascent of granitic magmas from its source; (4) the modification of the composition of granite magmas owing to fractional crystallization; and (5) the progressive availability (through dissolution) of slow diffusing species and their control of the effective bulk composition of a system. These cases collectively illustrate thermodynamically constrained methods for modelling systems that involve mass transfer.