bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the radio image of relativistic jets – I. Internal structure, Doppler boosting, and polarization maps
Authors: Chernoglazov A V , Beskin V S , Pariev V I 
Published: June 2019

ABSTRACT
In this first paper from forthcoming series of works devoted to radio image of relativistic jets from active galactic nuclei the role of internal structure of a flow is discussed. We determine the radial profiles of all physical values for reasonable Michel magnetization parameter σM and ambient pressure Pext. Maps of Doppler boosting factor δ and observed directions of linear polarization of synchrotron emission are also constructed.
NIHAO – XXII. Introducing black hole formation, accretion, and feedback into the NIHAO simulation suite
Authors: Blank Marvin , Macciò Andrea V , Dutton Aaron A , Obreja Aura 
Published: June 2019

ABSTRACT
We introduce algorithms for black hole physics, i.e. black hole formation, accretion, and feedback, into the Numerical Investigation of a Hundred Astrophysical Objects (NIHAO) project of galaxy simulations. This enables us to study high mass, elliptical galaxies, where feedback from the central black hole is generally thought to have a significant effect on their evolution. We furthermore extend the NIHAO suite by 45 simulations that encompass z = 0 halo masses from 1 × 1012 to $4 \times 10^{13}\, \mathrm{M}_{\odot }$, and resimulate five galaxies from the original NIHAO sample with black hole physics, which have z = 0 halo masses from 8 × 1011 to $3 \times 10^{12}\, \mathrm{M}_{\odot }$. Now NIHAO contains 144 different galaxies and thus has the largest sample of zoom-in simulations of galaxies, spanning z = 0 halo masses from 9 × 108 to $4 \times 10^{13}\, \mathrm{M}_{\odot }$. In this paper we focus on testing the algorithms and calibrating their free parameters against the stellar mass versus halo mass relation and the black hole mass versus stellar mass relation. We also investigate the scatter of these relations, which we find is a decreasing function with time and thus in agreement with observations. For our fiducial choice of parameters we successfully quench star formation in objects above a z = 0 halo mass of $10^{12}\, \mathrm{M}_{\odot }$, thus transforming them into red and dead galaxies.
Bayesian hierarchical inference of asteroseismic inclination angles
Authors: Kuszlewicz James S , Chaplin William J , North Thomas S H , Farr Will M , Bell Keaton J , Davies Guy R , Campante Tiago L , Hekker Saskia 
Published: June 2019

Abstract
The stellar inclination angle – the angle between the rotation axis of a star and our line of sight – provides valuable information in many different areas, from the characterization of the geometry of exoplanetary and eclipsing binary systems to the formation and evolution of those systems. We propose a method based on asteroseismology and a Bayesian hierarchical scheme for extracting the inclination angle of a single star. This hierarchical method therefore provides a means to both accurately and robustly extract inclination angles from red giant stars. We successfully apply this technique to an artificial data set with an underlying isotropic inclination angle distribution to verify the method. We also apply this technique to 123 red giant stars observed with Kepler. We also show the need for a selection function to account for possible population-level biases, which are not present in individual star-by-star cases, in order to extend the hierarchical method towards inferring underlying population inclination angle distributions.
The build-up of pseudo-bulges in a hierarchical universe
Authors: Izquierdo-Villalba David , Bonoli Silvia , Spinoso Daniele , Rosas-Guevara Yetli , Henriques Bruno M B , Hernández-Monteagudo Carlos 
Published: June 2019

ABSTRACT
We study the cosmological build-up of pseudo-bulges using the L-Galaxies semi-analytical model for galaxy formation with a new approach for following separately the assembly of classical bulges and pseudo-bulges. Classical bulges are assumed to be the result of violent processes (i.e. mergers and starbursts), while the formation of pseudo-bulges is connected to the secular growth of discs. We apply the model to both the Millennium and the Millennium II simulations, in order to study our results across a wide range of stellar masses ($\rm 10^{7}\!-\!10^{11.5}\, {\rm M}_{\odot }$). We find that z = 0 pseudo-bulges mainly reside in galaxies of $\mathit{ M}_{\rm stellar} \, {\sim }\, 10^{10}\!-\!10^{10.5}\, {\rm M}_{\odot }$ ($\mathit{ M}_{\rm halo} \, {\sim }\, 10^{11.5}\!-\!10^{12}\, {\rm M}_{\odot }$) and we recover structural properties of these objects (e.g. sizes and bulge-to-total ratios) that are in good agreement with observational results. Tracing their formation history, we find that pseudo-bulges assembled in galaxies with a very quiet merger history, as opposed to the host galaxies of classical bulges. Regarding the bulge structure, we find that $\, {\sim }\, 30{{\ \rm per\ cent}}$ of the galaxies with a predominant pseudo-bulge feature a composite structure, hosting both a pseudo- and a classical bulge component. The classical component typically constitutes ${\sim }\, 10{{\ \rm per\ cent}}$ of the total bulge galaxy mass. When looking at the properties of the host galaxies, we find that z = 0 pseudo-bulges are hosted by main-sequence galaxies, characterized by a stellar population which is generally younger compared to the one of the hosts of classical bulges.
A general approach to quenching and galactic conformity
Authors: Sin Larry P T , Lilly Simon J , Henriques Bruno M B 
Published: June 2019

ABSTRACT
We develop a conceptual framework and methodology to study the drivers of the quenching of galaxies, including the drivers of galactic conformity. The framework is centred on the statistic Δ, which is defined as the difference between the observed star formation state of a galaxy, and a prediction of its state based on an empirical model of quenching. In particular, this work uses the average quenching effects of stellar mass M* and local density δ to construct an empirical model of quenching. Δ is therefore a residual which reflects the effects of drivers of quenching not captured by M* and δ, or so-called hidden variables. Through a toy model, we explore how the statistical properties of Δ can be used to learn about the internal and external hidden variables which control the quenching of a sample of galaxies. We then apply this analysis to a sample of local galaxies and find that, after accounting for the average quenching effects of M* and δ, Δ remains correlated out to separations of 3 Mpc. Furthermore, we find that external hidden variables remain important for driving the residual quenching of low-mass galaxies, while the residual quenching of high-mass galaxies is driven mostly by internal properties. These results, along with a similar analysis of a semi-analytical mock catalogue, suggest that it is necessary to consider halo-related properties as candidates for hidden variables. A preliminary halo-based analysis indicates that much of the correlation of Δ can be attributed to the physics associated with individual haloes.
DNMT3B shapes the mCA landscape and regulates mCG for promoter bivalency in human embryonic stem cells
Authors: Tan Hong Kee , Wu Chan-Shuo , Li Jia , Tan Zi Hui , Hoffman Jordan R , Fry Christopher J , Yang Henry , Di Ruscio Annalisa , Tenen Daniel G 
Published: June 2019

Abstract
DNMT3B is known as a de novo DNA methyltransferase. However, its preferential target sites for DNA methylation are largely unknown. Our analysis on ChIP-seq experiment in human embryonic stem cells (hESC) revealed that DNMT3B, mCA and H3K36me3 share the same genomic distribution profile. Deletion of DNMT3B or its histone-interacting domain (PWWP) demolished mCA in hESCs, suggesting that PWWP domain of DNMT3B directs the formation of mCA landscape. In contrast to the common presumption that PWWP guides DNMT3B-mediated mCG deposition, we found that deleting PWWP does not affect the mCG landscape. Nonetheless, DNMT3B knockout led to the formation of 2985 de novo hypomethylated regions at annotated promoter sites. Upon knockout, most of these promoters gain the bivalent marks, H3K4me3 and H3K27me3. We call them spurious bivalent promoters. Gene ontology analysis associated spurious bivalent promoters with development and cell differentiation. Overall, we found the importance of DNMT3B for shaping the mCA landscape and for maintaining the fidelity of the bivalent promoters in hESCs.
Germline genetic landscape of pediatric central nervous system tumors
Authors: Muskens Ivo S , Zhang Chenan , de Smith Adam J , Biegel Jaclyn A , Walsh Kyle M , Wiemels Joseph L 
Published: June 2019

AbstractCentral nervous system (CNS) tumors are the second most common type of cancer among children. Depending on histopathology, anatomic location, and genomic factors, specific subgroups of brain tumors have some of the highest cancer-related mortality rates or result in considerable lifelong morbidity. Pediatric CNS tumors often occur in patients with genetic predisposition, at times revealing underlying cancer predisposition syndromes. Advances in next-generation sequencing (NGS) have resulted in the identification of an increasing number of cancer predisposition genes. In this review, the literature on genetic predisposition to pediatric CNS tumors is evaluated with a discussion of potential future targets for NGS and clinical implications. Furthermore, we explore potential strategies for enhancing the understanding of genetic predisposition of pediatric CNS tumors, including evaluation of non-European populations, pan-genomic approaches, and large collaborative studies.
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Management of Patients With Myelomeningocele: Whether Prenatal or Postnatal Closure Affects Future Ambulatory Status
Authors: Bauer David F , Beier Alexandra D , Nikas Dimitrios C , Assassi Nadege , Blount Jeffrey , Durham Susan R , Flannery Ann Marie , Klimo Jr Paul , McClung-Smith Catherine , Rehring Patricia , Tamber Mandeep S , Tyagi Rachana , Mazzola Catherine A 
Published: June 2019

Abstract

BACKGROUND
Myelomeningocele (MM) is an open neural tube defect treated by pediatric neurosurgeons with prenatal or postnatal closure.

OBJECTIVE
The objective of this systematic review was to answer the question: What is the evidence for the effectiveness of prenatal vs postnatal closure of MM regarding short and long-term ambulatory status? Treatment recommendations were provided based on the available evidence.

METHODS
The National Library of Medicine PubMed database and Embase were queried using MeSH headings and keywords relevant to ambulatory status after prenatal or postnatal closure of MM. Abstracts were reviewed to identify which studies met the inclusion criteria. An evidence table was assembled summarizing the studies and the quality of evidence (Classes I-III). Based on the quality of the literature, a recommendation was rendered (Level I, II, or III).

RESULTS
One randomized controlled trial (Class II) and 3 retrospective cohort studies (Class III) were included as evidence. Initial ambulatory status depended on anatomic level of the neural tube defect. In the short term, prenatal closure may improve ambulatory status compared to postnatal closure. Spinal cord tethering or dermoid inclusion cyst has been associated with neurologic deterioration in infants closed in utero and after birth. Ambulation may cease in both groups over time. No long-term studies evaluated whether there is a difference in the ability to ambulate upon reaching adulthood.

CONCLUSION
Prenatal closure of MM may improve ambulatory status in the short term (Level II). Spinal cord tethering in both groups caused deterioration in the ability to walk. Evaluation and treatment of spinal cord tethering may help maintain ambulatory status (Level III). No studies evaluate whether prenatal or postnatal repair provides improved ability to ambulate upon reaching adulthood.
The full guideline can be found at https://www.cns.org/guidelines/guidelines-spina-bifida-chapter-3.
The Myth of Flexible Universality: Human Rights and the Limits of Comparative Naturalism
Authors: Heinze Eric 
Published: June 2019

Abstract
Many writers reject the notion of universal human rights, insisting on their historically recent, Western-secular character. Other theorists emphasise mutual exchange between human rights and systems such as Confucianism, Buddhism and Islam. They celebrate a common ground that would appear, moreover, to enhance the case for universality. This article acknowledges that common ground but rejects the view that it can strengthen the case for universality. Any such ‘exchange’, far from being mutual, turns out to be dictated entirely by human rights. Familiar rhetoric about the supposed flexibility of human rights law, which would suggest genuinely interactive relationships between it and other belief systems, flatly contradicts its higher-law claims. Genuinely flexible human rights could only ever arise either (i) in the trivial sense that any broadly formulated legal rule ends up applied to a range of situations or (ii) in the untenable sense that human rights law would accommodate serious violations.
Involvement of HD-ZIP I transcription factors LcHB2 and LcHB3 in fruitlet abscission by promoting transcription of genes related to the biosynthesis of ethylene and ABA in litchi
Authors: Ma Xingshuai , Li Caiqin , Huang Xuming , Wang Huicong , Wu Hong , Zhao Minglei , Li Jianguo 
Published: June 2019

Abstract
Abnormal fruitlet abscission is a limiting factor in the production of litchi, an economically important fruit in Southern Asia. Both ethylene and abscisic acid (ABA) induce organ abscission in plants. Although ACS/ACO and NCED genes are known to encode key enzymes required for ethylene and ABA biosynthesis, respectively, the transcriptional regulation of these genes is unclear in the process of plant organ shedding. Here, two polygalacturonase (PG) genes (LcPG1 and LcPG2) and two novel homeodomain-leucine zipper I transcription factors genes (LcHB2 and LcHB3) were identified as key genes associated with the fruitlet abscission in litchi. The expression of LcPG1 and LcPG2 was strongly associated with litchi fruitlet abscission, consistent with enhanced PG activity and reduced homogalacturonan content in fruitlet abscission zones (FAZs). The promoter activities of LcPG1/2 were enhanced by ethephon and ABA. In addition, the production of ethylene and ABA in fruitlets was significantly increased during fruit abscission. Consistently, expression of five genes (LcACO2, LcACO3, LcACS1, LcACS4 and LcACS7) related to ethylene biosynthesis and one gene (LcNCED3) related to ABA biosynthesis in FAZs were activated. Further, electrophoretic mobility shift assays and transient expression experiments demonstrated that both LcHB2 and LcHB3 could directly bind to the promoter of LcACO2/3, LcACS1/4/7 and LcNCED3 genes and activate their expression. Collectively, we propose that LcHB2/3 are involved in the litchi fruitlet abscission through positive regulation of ethylene and ABA biosynthesis.
Homoplasy and extinction: the phylogeny of cassidulid echinoids (Echinodermata)
Authors: Souto Camilla , Mooi Rich , Martins Luciana , Menegola Carla , Marshall Charles R 
Published: June 2019

AbstractInclusion of fossils can be crucial to address evolutionary questions, because their unique morphology, often drastically modified in recent species, can improve phylogenetic resolution. We performed a cladistic analysis of 45 cassidulids with 98 characters, which resulted in 24 most parsimonious trees. The strict consensus recovers three major cassiduloid clades, and the monophyly of the family Cassidulidae is not supported. Ancillary analyses to determine the sensitivity of the phylogeny to missing data do not result in significantly different topologies. The taxonomic implications of these results, including the description of a new cassiduloid family and the evolution of some morphological features, are discussed. Cassiduloids (as defined here) most probably originated in the Early Cretaceous, and their evolutionary history has been dominated by high levels of homoplasy and a dearth of unique, novel traits. Despite their high diversity during the Palaeogene, there are only seven extant cassiduloid species, and three of these are relicts of lineages dating back to the Eocene. Future studies of the biology of these poorly known species, some of which brood their young, will yield further insights into the evolutionary history of this group.
NPs' use of guidelines to diagnose and treat childhood ADHD
Authors: Jansen Mashelle 
Published: June 2019

Abstract:
Current research on NPs' use of the American Academy of Pediatrics (AAP) Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents is limited. This cross-sectional survey examined 89 NPs in Upstate New York regarding self-reported practice behaviors based on the guideline. Most NPs followed at least 50% of the AAP guideline for diagnosis and treatment. However, use of all criteria was less than optimal.
Platelet-Rich Plasma and Its Utilities in Alopecia: A Systematic Review
Authors: Hesseler Michael J. , Shyam Nikhil 
Published: June 2019

BACKGROUND
The use of platelet-rich plasma is becoming more prevalent in the field of dermatology. Variable preparation techniques and treatment methods have been described with reported success in alopecia.

OBJECTIVE
To consolidate the available evidence of platelet-rich plasma and its utility in the treatment of alopecia for the practicing dermatologist.

METHODS
Evaluating the available evidence up to May 31, 2018, a search was conducted in the PubMed database for “platelet rich plasma” or “platelet releasate” or “platelet gel” or “PRP” and “dermatology” or “skin” or “hair” or “cutaneous.”

RESULTS
Nineteen articles met the inclusion criteria for analysis including 3 alopecia areata studies with a total of 71 patients and 16 androgenetic alopecia studies with a total of 389 patients. Although the heterogeneity of the studies prevented direct comparisons and subsequent statistical analysis, the majority demonstrated that platelet-rich plasma produced successful hair growth in androgenetic alopecia and alopecia areata.

CONCLUSION
This review advocates for the use of platelet-rich plasma in 3 to 4 monthly sessions for the treatment of alopecia. Future studies should include a detailed description of the platelet-rich plasma isolation process to allow for comparison among studies, provide reproducibility, and generate a standardized treatment protocol.
Preoperative Blood Management Strategy for Elective Hip and Knee Arthroplasty
Authors: Kurian Dinesh J. , Guinn Nicole R. , Hunting John , Gamble John F. , Hopkins Thomas J. , Grimsley Aime , Guercio Jason R. , Bolognesi Michael P. , Schroeder Rebecca , Aronson Solomon ,   on behalf of the Duke Perioperative Enhancement Team (POET)
Published: June 2019

ABSTRACTTo improve quality and outcomes, a preoperative anemia clinic (PAC) was established to screen, evaluate, and manage preoperative anemia. A retrospective review of primary and revision hip and knee arthroplasty patients from August 2013 to September 2017 was conducted. Patients at “high risk” for transfusion were referred to PAC for treatment with iron, erythropoietin, or both based on anemia type. Preoperative anemia clinic referred patients were compared with a 1:3 historic propensity-matched control set of patients to help determine impact of PAC. Forty PAC patients were compared with 120 control patients. Among PAC patients, 26 (63.41%) received iron only, 3 (7.32%) received erythropoietin (EPO) only, and 12 (29.27%) received both. Preoperative hemoglobin significantly increased in the treatment group (median [interquartile range] 10.9 g/dl [10.3–11.2] vs. 12.0 g/dl [11.2–12.7];p< .001). Four PAC patients (10.00%) received red blood cell transfusions compared with 29 (24.17%) from matched controls (p= .055). In addition, the PAC cohort had higher postoperative nadir hemoglobin levels (mean [SD] 9.7 g/dl [1.31] vs. 8.7 g/dl [1.25];p< .001). High-risk patients appropriately treated with iron and/or EPO before surgery demonstrate a significant increase in preoperative hemoglobin, trend toward decrease perioperative transfusion, and increased hemoglobin levels postoperatively compared with matched controls.
A proposal for a useful algorithm to diagnose small hepatocellular carcinoma on MRI
Authors: Coty Jean-Baptiste , Paisant Anita , Esvan Maxime , Lonjon Julie , Seror Olivier , Rode Agnès , Ronot Maxime , Lebigot Jérôme , Vilgrain Valérie , Aubé Christophe 
Published: June 2019

Objective
To assess MRI features for the diagnosis of small hepatocellular carcinomas (HCCs) and especially for nodules not showing both of the typical hallmarks.

Patients and methods
Three hundred and sixty-four cirrhotic patients underwent liver MRI for 10–30 mm nodules suggestive of HCC. The diagnostic performances of MRI features [T1, T2; diffusion-weighted (DW) imaging signal, enhancement, capsule, fat content] were tested, both individually and in association with both typical hallmarks and as substitutions for one hallmark. The diagnostic reference was obtained using a multifactorial algorithm ensuring high specificity (Sp).

Results
Four hundred and ninety-three nodules were analyzed. No alternative features, associations or substitutions outperformed the typical hallmarks for the diagnosis of HCC. For 10–20 mm nodules not displaying one of the typical hallmarks, hyperintensity on DW images was the most accurate substitutive sign, providing a sensitivity of 71.4% and Sp of 75% for nodules without arterial enhancement and sensitivity = 65.2% and Sp = 66% for nodules without washout on the portal or delayed phases. A new diagnostic algorithm, including typical hallmarks as a first step then the best-performing substitutive signs (capsule presence or DW hyperintensity) in combination with the nonmissing typical hallmark as a second step, enabled the correct classification of 77.7% of all nodules, regardless of size.

Conclusion
Using MRI, the typical hallmarks remain the best criteria for the diagnosis of small HCCs. However, by incorporating other MRI features, it is possible to build a simple algorithm enabling the noninvasive diagnosis of HCCs displaying both or only one of the typical hallmarks.