bluuebunny/crossref_metadata_2025_split huggingface dataset:
Portföy Yönetiminde Bayesci Yaklaşımlar: BIST30 Endeksi Üzerine Bir Uygulama
Authors: İşcanoğlu Çekiç Ayşegül 
Published: June 2019

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Markowitz’in ortalama varyans portföyü matematiğin, finansal uygulamalarda kullanılmasına öncülük etmesi açısından bir dönüm noktası olmuştur. Aynı zamanda model, hesap kolaylığı sebebiyle 1-dönemlik portföy kararlarının hızlı alınması açısından da önemlidir. Fakat zaman içinde yapılan çalışmalar, ortalama-varyans portföyünün performansının parametre, tahmin hataları sebebi ile oldukça düşük olduğunu göstermiştir. Bu sebeple literatürde bu sorunun önüne geçebilmek amacıyla birçok yeni teori ve yöntem/ yaklaşım geliştirilmiştir. Bayesci portföy metodu bunlardan bir tanesidir. Bu çalışma, ortalama-varyans modeli üzerine kurulan üç bayesci yaklaşımı: Jorion (1985,1986), Kan ve Zhou (2007), Tu ve Zhou (2011), Markowitz’in ortalama-varyans modeli ile karşılaştırmayı amaçlamaktadır. Ayrıca bir baz model olarak, eşit-ağırlıklı portföy yöntemi de diğer yöntemlerle karşılaştırılmıştır. Bu amaç doğrultusunda, BİST30 endeksinde işlem gören 30 hisse senedine ait 2010-2017 yılları arasındaki günlük getiri serileri kullanılmış ve gerçek getirilerden simülasyon yardımıyla oluşturulan farklı büyüklükteki portföylerin performansları karşılaştırılmaya çalışılmıştır. Genel olarak değerlendirildiğinde, en iyi performans gösteren portföyün Kan ve Zhou’nun önerdiği Bayesci portföy olduğu sonucuna varılmıştır.&nbsp;
Nüfuzumu Kullanırken Ben: Türkiye’deki Moda Instabloggerlarının Ürün Yerleştirme Uygulamaları Üzerine bir İçerik Analizi
Authors: ŞENER Gül , ÖZTÜRK Eda , SUHER H. Kemal 
Published: June 2019

Farkındalık ve ürünlere yönelik talep yaratma konusunda giderek artan nüfuzları, bloggerları
markalar için vazgeçilmez birer pazarlama oyuncusuna d.nüştürmüştür. Zaman içinde
oluşturdukları takipçi tabanlarına yönelik sürekli içerik paylaşımında bulunan bu dijital elitler,
Nüfuz Pazarlaması’nın yeni otoriteleri haline gelmiştir. Markalar ise ticari değeri olan bu içeriğin
parçası olmanın yolu olarak genellikle ürün yerleştirme çalışmalarını seçmektedir. Bu çalışmanın
amacı, Türkiye’deki moda Instabloggerları’nın yaptıkları Instagram paylaşımlarına içerik analizi
yöntemi uygulayarak ürün yerleştirme pratiklerinin belirleyici unsurlarını ortaya koymaktır.
Yapılan analiz sonucunda, hesabın büyüklüğü (Mega, Orta Gü., Mikro) ve türünün (Sokak
Modası/Yüksek Moda) yapılan ürün yerleştirmelerin belirginlik, interaktivite, anlatısal uyum ve
etkileşim düzeyinde istatistiksel olarak anlamlı farklar yarattığı bulgulanmıştır.
Evaluation of Cardioprotective activity of Asparagus racemosus against Doxorubicin induced cardiotoxicity in albino rats: an experimental study
Authors: Vishwakarma Pinki , Chatterjee Manisha , Sharma Monica , Saini Manish , Goel Rajkumar , Saxena K. K. 
Published: June 2019

Background: Cardiotoxicity is one of the most feared side effects of anticancer agents like Doxorubicin. Asparagus racemosus is a widely used medicinal plant in Indian system of medicine known for its antioxidant activity. In certain studies ethanol extract of Asparagus racemosus has shown to possess cardioprotective activity in experimental animals while in some other studies cardioprotective potential of Asparagus racemosus has not been demonstrated. Therefore, due to the controversial action, the present study was designed to explore the cardioprotective effect of aqueous effect of Asparagus racemosus against doxorubicin induced cardiotoxity.Methods: Following approval from Institutional Animal Ethics Committee of L.L.R.M Medical College registered under CPCSEA, India, this study was conducted in which 30 rats were randomized into five groups of six rats each. Group I received 2 ml/kg b.w. normal saline p.o for 21 days, group II apart from receiving pellet diet and normal saline for 21 days were treated with Doxorubicin in a single dose of 20 mg/kg intraperitoneally on the 21st day, group III and group IV received aqueous extract of Asparagus racemosus in doses of 250 mg/kg/day and 500 mg/kg/day respectively p.o. for 21 days followed by administration of Doxorubicin (20 mg/kg i.p.) on the 21st day, Group V received Carvedilol in doses of 30 mg/kg/day p.o. for 21 days followed by administration of Doxorubicin (20mg/kg i.p) on the 21st day. Then they were anaesthetized and blood sample was collected from abdominal aorta for performing blood test i.e. Creatinine kinase MB fraction (CK-MB), Lactate dehydrogenase (LDH), Serum glutamate oxaloacetate transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT). After blood collection the animals were sacrificed and heart was dissected out for histopathological study. The data obtained was organized and analysed by suitable statistical methods i.e. ANOVA followed by Post Hoc test.Results: CK-MB, LDH, SGOT and SGPT levels were found to be significantly raised (p<0.001) in Doxorubicin treated group. Asparagus racemosus pretreated groups exhibited significant limitation (p<0.001) in rise in levels of CK-MB,LDH,SGOT and SGPT levels in a dose dependent manner following Doxorubicin administration which were comparable to the group treated with the standard cardioprotective drug Carvedilol. Histopathological changes further corroborated cardioprotective potential of Asparagus racemosus.Conclusions: The present study concluded that aqueous extract of Asparagus racemosus possess cardioprotective potential against Doxorubicin induced cardiotoxicity.
Density Functional Study on Benzene, Toluene, Ethylbenzene and Xylene Adsorptions on ZnO(100) Surface
Authors: Nugraha Nugraha , Saputro Adhitya Gandaryus , Agusta Mohammad Kemal , Akbar Fiki Taufik , Pramudya Aditya Dimas 
Published: June 2019

We study the interaction between benzene, toluene, ethylbenzene and xylene (BTEX) molecules with ZnO(100) surface by means of density functional theory-based calculations. We find that these interactions result in the physical adsorptions of BTEX gases with adsorption distances larger than 2 Å. These adsorptions are governed by the van der Waals interaction instead of the covalent interaction. We also find that the trend of the strength of BTX adsorptions on ZnO(100) surface is in line with the experimental trend of sensitivity of ZnO material towards BTX gases (benzene < tolune < xylene). We explain this relation by using one of the sensing mechanism within the ionosorption model. By using this relation, we also predict that the response of ZnO towards ethylbenzene will be similar to the response towards toluene since these two molecules have similar adsorption energies on ZnO(100) surface.
Small Bowel Obstruction Secondary to Entrapment in a Minimally Displaced Acetabular Fracture
Authors: Westberg Scott , Kupfer Nathalie , Fung Christopher , Widder Sandy , Glasgow Donald 
Published: June 2019

Case:
We present a unique case of bowel entrapment within a minimally displaced acetabular fracture. Our patient was injured after a fall from height. He was able to walk with minimal pain, and presented to hospital the following day for symptoms consistent with bowel obstruction. Imaging demonstrated a transition point at the fracture site. He was taken for emergency surgical decompression, bowel repair, and irrigation of his hip.

Conclusions:
Bowel entrapment within a pelvic fracture is rare. Our case illustrates the importance of maintaining a high level of suspicion, despite fracture displacement, to allow early diagnosis and appropriate management.
Spontaneous Radial Nerve Palsy due to an Unrecognized Myofibroma
Authors: Hinchcliff Katharine M. , Rogers Jessica , Sarohia Dani , Hornick Jason , Szabo Robert M. 
Published: June 2019

Case:
A 33-year-old woman presented with a six-month history of spontaneous radial nerve palsy and no identified lesion on imaging. She underwent operative exploration where an hourglass deformity was seen and resected. Pathology returned as a rare tumor, a myofibroma. The patient regained full radial nerve function.

Conclusions:
A trial of observation is often indicated in the cases of isolated nerve palsy where anatomic lesions have been eliminated. This case highlights that imaging studies can miss a tumor involving nerve and that painless, spontaneous nerve palsy may be a time where early surgical intervention offers a better chance of recovery.
Effect of Dexmedetomidine on Duration of Mechanical Ventilation in Septic Patients: A Systematic Review and Meta-Analysis
Authors: chen peifen , Jiang Jihong , Zhang Yunhe , Qiu Zhihui , Levy Mitchell M. , Hu Baoji , Li Guobao 
Published: June 2019

Abstract
Background

Because of its analgesic and light sedative properties, the highly selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) has been suggested for the treatment of septic patients, but its effect on the duration of mechanical ventilation remains unclear. The present study was conducted to review the extant literature in DEX and determine its influence on ventilation time in adult septic patients.

Methods

We searched the databases of PubMed, Cochrane, and EMBASE until 20 January 2019 using a strategy without language restriction. Two researchers independently reviewed the titles and abstracts and then selected potentially relevant randomized controlled trials that evaluated the influence of DEX on ventilation time in adult septic patients. Two authors independently extracted data from the included studies and performed a meta-analysis using Review Manager.

Results

Four studies with a total of 349 patients were included. The trials conducted in these studies indicated that DEX was associated with significantly different durations of mechanical ventilation (MD 0.65, 95% CI, -0.13 to 1.42, P = 0.10). However, there were significant differences in ventilator-free days (MD 3.57, 95% CI, 0.26 to 6.89, P = 0.03) and 28-day mortality (RR 0.61, 95% CI, 0.49 to 0.94, P = 0.02) in the septic patients.

Conclusion

Although the administration of DEX did not improve the duration of mechanical ventilation, it increased the number of ventilator-free days and 28-day mortality in the adult septic patients in this study.
The Ability of Different Imputation Methods for Missing Values in Mental Measurement Questionnaires
Authors: Xu Xueying , Xia Leizhen , Zhang Qimeng , Wu Shaoning , Wu Mingcheng , Liu Hongbo 
Published: June 2019

Abstract
Background

Incomplete data are of particular important influence in mental measurement questionnaires. Most experts, however, mostly focus on clinical trials and cohort studies and generally pay less attention to this deficiency. We aim to compare the performance of in terms of accuracy and precision of four common methods for handling items missing from different psychology questionnaires according to the items non-response rates.

Method

All data were drawn from the previous studies including the self-acceptance scale (SAQ), the activities of daily living scale (ADL) and self-esteem scale (RSES). SAQ and ADL dataset, simulation group, were used to compare and assess the ability of four imputation methods which are direct deletion, mode imputation, Hot-deck imputation and multiple imputation by absolute deviation, the root mean square error and average relative error in missing proportions of 5%, 10%, 15% and 20%. RSES dataset, validation group, was used to test the application of imputation methods. All analyses were finished by SAS 9.4.

Results

The biases obtained by MI are the smallest under various missing proportions. HD imputation approach performed the lowest absolute deviation of standard deviation values. But they got the semblable results and the performances of them are obviously better than direct deletion and mode imputation. In a real world situation, the respondents' average score in complete data set was 28.22 ± 4.63, which are not much different from imputed datasets. The direction of the influence of the five factors on self-esteem was consistent, although there were some differences in the size and range of OR values in logistic regression model.

Conclusion

MI shows the best performance while it demands slightly more data analytic capacity and skills of programming. And HD could be considered to impute missing values in psychological investigation when MI cannot be performed due to limited circumstances.
Relation between carotid vulnerable plaques and peripheral leukocyte: A case-control study of comparison utilizing multi-parametric CEUS
Authors: Luo Xianghong , Li Wanbin , Bai Yun , Du Lianfang , Wu Rong , Li Zhaojun 
Published: June 2019

Abstract
Background
This study evaluates carotid vulnerable plaques using contrast-enhanced ultrasound (CEUS) and explores the relationship between vulnerable plaques and leukocytes.
Methods
Sixty-two symptomatic and 54 asymptomatic patients underwent CEUS. The images were analyzed using time-intensity and fitting curves, and peak (PTIC), mean (MTIC), peak (PFC), sharpness (SFC), and area under the curve (AUCFC) were obtained. The relations between CEUS parameters and leukocytes were analyzed.
Results
In the symptomatic group, total leukocytes and neutrophils were higher, while lymphocyte was decreased; PTIC, MTIC, PFC, SFC and AUCFC were significantly higher; MTIC and AUCFC were negatively correlated with lymphocytes, and MTIC was positively correlated with neutrophils. Classification and regression tree analysis showed that MTIC at a cutoff of 20.8 and AUCFC at a cutoff of 8.8 resulted in a predictive of acute cerebral infarction, accuracy of 84.3%, sensitivity of 87.1%, and specificity of 81.5%.
Conclusions
CEUS is a feasible predictor of vulnerable plaques, and related to leukocytes.
Proteomics profiling and pathway analysis of hippocampal aging in rhesus monkeys
Authors: Meng Shu , Xia Wenchao , Pan Meng , He Zhanlong , Ge Wei 
Published: June 2019

Abstract
Background

Aged rhesus monkeys exhibit deficits in memory mediated by the hippocampus. Although extensive research has been carried out on the characteristics of human hippocampal aging, there is still very little scientific understanding of the changes associated with hippocampal aging in rhesus monkeys. To explore the proteomics profiling and pathway-related changes in the rhesus hippocampus during the aging process, we conducted a high throughput quantitative proteomics analysis of hippocampal samples from two groups of rhesus macaques aged 6 years and 20 years, using 2-plex tandem mass tag (TMT) labeling. In addition, we used a comprehensive bioinformatics analysis approach to investigate the enriched signaling pathways of differentially expressed proteins (20-y vs. 6-y ≥1.20 or ≤ 0.83).

Results

In total, 3,260 proteins were identified with a high level of confidence in rhesus hippocampus. We found 367 differentially expressed proteins related to rhesus hippocampus aging. Based on biological pathway analysis, we found these aging-related proteins were predominantly enriched in the electron transport chain, NRF2 pathway, focal adhesion-PI3K-AKT-mTOR signaling pathway and cytoplasmic ribosome proteins. Data are available via ProteomeXchange with identifier PXD011398.

Conclusion

This study provides a further understanding of the proteomics profile related to rhesus hippocampal aging, which will help to elucidate the differences between rhesus and human hippocampal aging. These findings should make an important contribution to further mechanistic studies, marker selection and drug development for the prevention and treatment of aging or age-related neurodegeneration.
Systematic review of statistical methods for analyzing healthcare cost in administrative data
Authors: Dooley Mary , Simpson Kit N. , Bonilha Heather S. 
Published: June 2019

Abstract
BACKGROUND

Healthcare costs are increasing at alarming rates in the United States (US) putting a heavy burden on the healthcare reimbursement system. Cost and cost savings have become an important focus as health policy administrators are tasked with determining the most effective allocation of limited resources. The availability of large databases, such as administrative data, comes with many challenges for analyses, including: skewed data, inflated zero counts, and potential selection bias among comparison groups. Thus, it is imperative that they are evaluated correctly. There are many different methods currently being used to estimate costs including: generalized linear models with a log link, natural logarithm transformed costs, gamma distribution, median regression, two-part models, and Bayesian models. This systematic review will identify which methods are statistically and mathematically appropriate for large claims data.

METHODS

Scopus and Ovid were searched for potential statistical method papers using multivariable modelling of cost that were published up to the end of February 2018. Inclusion criteria required either a comparison of two or more statistical methods to analyze cost or one statistical method performed on two or more different types of cost data. This systematic review follows the guidelines according to Preferred Reposting Items for Systematic Reviews and Meta-Analysis (PRISMA).

RESULTS

The review identified 1,048 potential papers, of which, 80 met the inclusion criteria for a full article review. There was a total of 9 papers included in the systematic review; one paper included simulations and eight papers assessed real cost data. There were 28 models assessed across the nine papers with ordinary least squares (OLS) and generalized linear models (GLM) being the most common.

CONCLUSIONS

GLM using the gamma distribution was included in all but two of the comparisons. Most other models that were compared to the GLM Gamma distribution with log link found it to be the superior model in both simulated data and real administrative data.
Detection and application of genome-wide variations in peach for association and genetic relationship analysis
Authors: Guan Liping , Cao ke , Li yong , guo jian , xu qiang , Wang Lirong 
Published: June 2019

Abstract
Abstract
Background: Peach (Prunus persica L.) is a diploid species and model plant of the Rosaceae family. In the past decade, significant progress has been made in peach genetic research via DNA markers, but the number of these markers remains limited.
Results: In this study, we performed a genome-wide DNA markers detection based on sequencing data of six distantly related peach accessions. A total of 650,693~1,053,547 single nucleotide polymorphisms (SNPs), 114,227~178,968 small insertion/deletions (InDels), 8,386~12,298 structure variants (SVs), 2,111~2,581 copy number variants (CNVs) and 229,357~346,940 simple sequence repeats (SSRs) were detected and annotated. To demonstrate the application of DNA markers, 944 SNPs were filtered for association study of fruit ripening time and 15 highly polymorphic SSRs were selected to analyze the genetic relationship among 221 accessions.
Conclusions: The results showed that the use of high-throughput sequencing to develop DNA markers is fast and effective. Comprehensive identification of DNA markers, including SVs and SSRs, would be of benefit to genetic diversity evaluation, genetic mapping, and molecular breeding of peach.
Development and Validation of a Chinese Parental Health Literacy Questionnaire for Caregivers of Children from 0 to 3 Years Old
Authors: Zhang Yan , Li Mu , Jiang Hong , Shi Huijing , Xu Biao , Atkins Salla , Qian Xu 
Published: June 2019

Abstract
Background

Given the limited information on parental health literacy measurements, the study aimed to develop and validate the Chinese Parental Health Literacy Questionnaire for caregivers of children under three years old.

Methods

We conducted a validity and reliability study through a cross-sectional survey and test-retest analysis respectively between March and April 2017. 807 caregivers of children under three years old were recruited, among which 101 caregivers completed the test-retest assessment with two weeks interval. The reliability was determined by internal consistency, spilt-half reliability and test-retest reliability. The construct validity was assessed by confirmatory factor analysis.

Results

The 39-question Chinese Parental Health Literacy Questionnaire was shown with high internal consistency (Cronbach’s α=0.89), spilt-half reliability (Spearman-Brown coefficient=0.92) and test-retest reliability (Pearson correlation coefficient=0.82). The confirmatory factor analysis showed that the construct of the questionnaire fitted well with the hypothetical model. The participants’ test scores of the Chinese Parental Health Literacy Questionnaire in a cross-sectional survey were positively associated with caregivers being mothers, more educated, of children with Shanghai Hukou, having only one child in the family, having higher family income.

Conclusion

The Chinese Parental Health Literacy Questionnaire demonstrated good reliability and validity, which could potentially be used as an effective evaluation instrument to assess parental health literacy.
Optimisation of important processing conditions for rice bran sourdough fermentation using Lactobacillus plantarum
Authors: Bolarinwa Islamiyat Folashade , Hanis-Syazwani Mat Gani , Muhammad Kharidah 
Published: June 2019

The potentials of rice bran sourdough in bread making are recently gaining popularity. However, there is no information on the influence of processing conditions on the quality attributes of rice bran sourdough. To inves- tigate the influence of fermentation time and temperature on the levels of acidity (pH and TTA) in rice bran sour- dough fermented with L. plantarum, we applied response surface methodology (RSM). Furthermore, we studied the effect of different fermentation time and temperature on the total phenolic and volatile compounds in the sourdough. GC/MS measurements for the evolution of aroma volatile compounds (VOCs) in the rice bran sourdoughs were conducted. The higher and longer the fermentation temperature and time, the higher the acidity levels in the sour- doughs. Fermentation temperature and time do not have a significant effect on the total phenolic sourdough con- tents. Forty-seven VOCs were detected in the rice bran sourdoughs. The major VOCs were acetic acids, ethanol, 2-Methoxy-4-vinylphenol, Hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester, acetoin, and 2-methoxy-Phe- nol. The sourdough fermented at 35°C for 13 ho contained the largest number (27) of aroma compounds and had the highest acidity. These fermentation conditions are close to the optimal parameters (temperature – 33°C, duration –
12.5 hours), obtained as a result of applying RSM for rice bran fermentation. Thus, high quality bran sourdough can be produced at the temperature of 33°C for 12.5 hours. The results of this study will be useful to produce a quality rice bran sourdough bread with appealing aroma and a long shelf-life.