bluuebunny/crossref_metadata_2025_split huggingface dataset:
The increase of VEGF expressions and new blood vessels formation in Wistar rats induced with post-tooth extraction sponge amnion
Authors: Rizal Moh. Basroni , Munadziroh Elly , Kriswandini Indah Listiana 
Published: June 2018

Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially triggering a wound healing response in the body. As a result, many methods have been applied to improve the wound healing process, especially in wounds resulting in complications. One such method involves the application of amniotic membrane which has anti-inflammatory, anti-bacterial, anti-fibrosis, anti-scarring properties with low immunogenicity, epithelialization effects, and secretory leukocyte protease inhibitor (SLPI). It also contains collagen, various growth factors, transferrin, fibronectin, nidogen, proteoglycans, hyaluronan, and laminin. Purpose: This study aimed to determine the effects of sponge amnion on the number of VEGF expressions and new blood vessels in post-tooth extraction wounds of Wistar rats. Methods: Sponge amnion was produced by mixing freeze-dried amnion membrane from the Tissue Bank at RSUD Dr. Soetomo with 1% gelatin before freeze drying the mixture. Wistar rats were then divided into two groups. In Group 1, referred to as the control group, the post-extraction wounds of the rats received no treatment. Meanwhile, in Group 2, the treatment group, the subjects’ post-extraction wounds were treated with sponge amnion. The rats of both groups were sacrificed on day 3 to allow observation of the number of VEGF expressions and new blood vessels. A statistical analysis test, a t-test, was subsequently conducted. Results: There was a significant difference in the number of new blood vessels in the control group and that of the treatment group with a p value of 0.018 (p<0.05). There was also a significant difference in VEGF expression between the two groups with a p value of 0.000 (p <0.05). Conclusion: Sponge amnion can generate a number of VEGF expressions and new blood vessels in the post-extraction wounds of Wistar rats.
PERPLEXING JURISDICTION RATIONE PERSONAE AND MATERIAE OF RWANDAN COMMERCIAL COURTS: TRADER AND COMMERCIAL ACTIVITY
Authors: Niyobuhungiro Joel 
Published: June 2018

Modernization of judiciary has prompted the reform of courts system in many countries whereby a trend of creating specialized courts is no doubt contributing to the needed justice. The creation of commercial courts, as specialized courts, has been and still is at the root of commercial development that contributes to economic growth of the country.Like any court, for commercial court to adjudicate case, a number of elements determining the court competence must be examined by the court seized. Jurisdiction ratione materiae and jurisdiction personae, inter alia, are the determining factors of the competence of commercial courts. However, it can be difficult, in some cases, to ascertain court competence in case the law establishing those courts has not clearly delineated for example matters over which courts shall have jurisdiction. In Rwanda, The Law n° 06/2012/OL of 14/09/2012 determining the organization, functioning and jurisdiction of commercial courts, which repealed the Law n° 59/2007 of 16/12/2007, neither does it define a commercial activity nor does it define a trader. This creates big perplexity in determining commercial courts competence insofar as jurisdiction ratione materiae and personae are concerned. Commercial activities are neither defined nor enumerated in Rwanda laws. Rwandan commercial courts judges have tried to unravel that perplexity and tried to solve this problem in their judgements. However, it will be submitted that challenges posed by lack of clear definition of trader and commercial activity or at least a list of commercial activities, calls for a clear stand of the legislator as far as jurisdiction ratione materiae and personae of Rwandan commercial courts are concerned.
Study and Reporting of Adverse Drug Reaction Patterns Among Organ Transplant Patients Receiving Tacrolimus Therapy in a Real World Post-Marketing Experience
Authors: Shobharam Sahu  , Poonam Rishishwar  , Chhaya Rathod  
Published: June 2018

With the availability of many immunosuppressive drugs for treatment of solid organ transplantation increase to a life span of patients who is receiving tacrolimus separately for End Stage of liver, heart and lung, kidney. But after all success of solid organ transplantation is purely dependent on proper course of immunosuppressive therapy. Tacrolimus is lactones antibiotic isolated from the fermentation of streptomyces tstkubaeis. This calcineurin inhibitor widely used for its immunosuppressive properties to increase patient survival and prevent graft function, organ rejection in solid organ transplant and graft-versus-host disease in transplant patients suppresses to enzyme for the growth of B cells and T cells. It was first approved for use to prevent graft rejection in 1994 for liver transplantation and in 1997 for kidney transplantation. The outcomes of this drug have varied due to differences in induction and maintenance therapy, drug dosing and monitoring. The aim of this study of an assessment and reporting of adverse drug reaction was to analyze the case reports of literature critically, conducted to monitor and evaluated the adverse events (AEs) and adverse drug reactions (ADRs) of immunosuppressive drug regimens, its causality, severity in therapy which is used various organ transplant patients and to document the pharmacotherapeutic actions taken for its management.
Apigenin and Quercetin: Potential Therapeutic Challenging Effective Against in Alzheimer’s Disease
Authors: Manmohan S. Jangdey  , Anshita Gupta  , Khomendra Sarwa  
Published: June 2018

Alzheimer's disease (AD) is an accelerating neurodegenerative disorder, dementia in the world. Current treatments for Alzheimer’s disease primarily focus on enhancement of cholinergic transmission & leading to neuronal dysfunction and loss in the brain. Flavonoid bioactive compounds are the major role for the designer of a new generation of therapeutic agents that are clinically effective in treating neurodegenerative diseases. Apigenin & quercetin are attractive biomarkers in this regards which has been epidemiological studies height a Neuroprotective and related to a lower risk of developing dementia or gradual decline its progressive. The continuing investigation of the potential preventive activity of quercetin and apigenin should be evaluated in long-term exposure clinical trials, using preparations with high bioavailability and promising to yield a possible remedy for this pervasive disease. Thus, the aim of the review, we analyzed the enhancing effects of apigenin and quercetin and discuss the potential of these compounds for Alzheimer’s disease prevention and treatment.
Regeneration of Aegle marmelos (l.) Through Enhanced Axillary Branching from Cotyledenory Node
Authors: Asha Gupta  , Tessy Thomas  , Shagufta Khan  
Published: June 2018

A complete protocol is standardized for invitro micropropogation of Aegle marmelos for the first time using cotyledonary nodes derived through invitro raised seedlings.Higher percentage of direct multiple shoots were regenerated from cotyledonary nodal segments through forced axillary branching. The cotyledonary nodes of invitro raised seedlings were used as explants for shoot formation on MS Medium supplemented with Cytokinins (BAP) and Auxins (NAA), either alone or in combinations. Maximum (80%) shoots having shoot length of 2-3 cm were achieved on MS medium fortified with BAP (1.0 mg/l) and NAA (0.5mg/l).By repeating sub culturing of the cotyledonary node on shoot multiplication medium followed by shoot elongation medium after each harvest of the newly formed shoots. Thus, from a single cotyledonary node, about 20-25 shoots were obtained. Shoots formed in vitro were best rooted on MS medium supplemented with 1.0-2.0 mg/l Napthalene acetic acid(NAA).
Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Focus on Mutations - Part 1
Authors: Russo Patrizia , Lococo Filippo , Kisialiou Aliaksei , Prinzi Giulia , Lamonaca Palma , Cardaci Vittorio , Tomino Carlo , Fini Massimo 
Published: June 2018

Background:
We report a comprehensive overview of current Chronic Obstructive
Lung Disease (COPD) therapies and discuss the development of possible new pharmacological
approaches based on “new” knowledge. Specifically, sensitivity/resistance to corticosteroids
is evaluated with a special focus on the role of gene mutations in drug response.

Objective:
Critically review the opportunities and the challenges occurring in the treatment of
COPD.

Conclusion:
Findings from “omics” trials should be used to learn more about biological targeted
drugs, and to select more specific drugs matching patient’s distinctive molecular profile.
Specific markers of inflammation such as the percentage of eosinophils are important in
determining sensitivity/resistance to corticosteroids. Specific gene variations (Single nucleotide
polymorphisms: SNPs) may influence drug sensitivity or resistance. Clinicians working
in a real-world need to have a suitable interpretation of molecular results together with a
guideline for the treatment and recommendations. Far more translational research is required
before new results from omics techniques can be applied in personalized medicine in realworld
settings.
The Efficacy of Omega-3 Supplement on Prevention of Retinopathy of Prematurity in Premature Infants: A Randomized Double-blinded Controlled trial
Authors: Khalesi Nasrin , Bordbar Arash , Khosravi Nastaran , Kabirian Morteza , Karimi Alireza 
Published: June 2018

Background:
The present study aimed to assess the efficacy of omega-3 in treating ROP in premature
infants.

Methods:
This randomized double-blinded controlled trial was performed on 160 premature infants with gestational
age lower than 32 weeks and birth weight < 1500 grams who were at risk of ROP development (Tehran,
Iran-2013). Children were randomly assigned to two groups. The intervention group received 300 mg omega-3
daily and the control group received sterile water as the placebo. The severity of ROP was defined according to
the International Classification of ROP.

Results:
The frequency of ROP was 7.5% in the group received omega-3 and 20.0% in the placebo group with a
significant difference (p = 0.021). Regarding the severity of ROP in the intervention group, ROP grade I was
found in two patients and ROP grade II in four patients; while ROP grade I, II, and III were revealed in 6, 6, and 4
patients in placebo group indicating a significant difference between the two groups (p = 0.001). Using the multivariate
logistic regression modeling with the presence of gender, gestational age, and birth weight, the use of
omega-3 was associated with reduced risk for ROP (p = 0.045).

Conclusion:
The use of omega-3 supplement can be an appropriate treatment option for the treatment of ROP in
premature infants.
An Integrated Multi-Label Classifier with Chemical-Chemical Interactions for Prediction of Chemical Toxicity Effects
Authors: Liu Tao , Chen Lei , Pan Xiaoyong 
Published: June 2018

Aims and Objective: Chemical toxicity effect is one of the major reasons for declining
candidate drugs. Detecting the toxicity effects of all chemicals can accelerate the procedures of drug
discovery. However, it is time-consuming and expensive to identify the toxicity effects of a given
chemical through traditional experiments. Designing quick, reliable and non-animal-involved
computational methods is an alternative way.

Method:
In this study, a novel integrated multi-label classifier was proposed. First, based on five types
of chemical-chemical interactions retrieved from STITCH, each of which is derived from one aspect of
chemicals, five individual classifiers were built. Then, several integrated classifiers were built by
integrating some or all individual classifiers.

Result and Conclusion:
By testing the integrated classifiers on a dataset with chemicals and their
toxicity effects in Accelrys Toxicity database and non-toxic chemicals with their performance evaluated
by jackknife test, an optimal integrated classifier was selected as the proposed classifier, which
provided quite high prediction accuracies and wide applications.
Oscillatory Dynamics of P53 Network With Time Delays
Authors: Wang Conghua , Yan Fang , Zhang Yuan , Liu Haihong , Zhang Linghai 
Published: June 2018

Aims and Objective: A large number of experimental evidences report that the oscillatory
dynamics of p53 would regulate the cell fate decisions. Moreover, multiple time delays are
ubiquitous in gene expression which have been demonstrated to lead to important consequences on
dynamics of genetic networks. Although delay-driven sustained oscillation in p53-based networks is
commonplace, the precise roles of such delays during the processes are not completely known.

Method:
Herein, an integrated model with five basic components and two time delays for the
network is developed. Using such time delays as the bifurcation parameter, the existence of Hopf
bifurcation is given by analyzing the relevant characteristic equations. Moreover, the effects of such
time delays are studied and the expression levels of the main components of the system are
compared when taking different parameters and time delays.

Result and Conclusion:
The above theoretical results indicated that the transcriptional and
translational delays can induce oscillation by undergoing a super-critical Hopf bifurcation. More
interestingly, the length of these delays can control the amplitude and period of the oscillation.
Furthermore, a certain range of model parameter values is essential for oscillation. Finally, we
illustrated the main results in detail through numerical simulations.
Immediate Postoperative Portable Radiograph After Total Knee Replacements: A Necessity or a Burden?
Authors: Aljawder Abdulla , Alomran Dana , Alayyoub Mohammed , Alkhalifa Fahad 
Published: June 2018

Background:Total Knee Replacement (TKR) is one of the most commonly performed orthopaedic surgery(1). Immediate postoperative portable radiographs are performed after primary TKR in order to identify any potential complications and technical flaws. It also serves as a reference for comparison with subsequent radiographs. The aim of this study was to evaluate the clinical and economical value of these radiographs in TKR. It compares the quality of the portable radiograph, taken immediately post-operation, with in-suite radiographs taken 5-7 weeks post-operationMethods:In this retrospective study, a consecutive series of 389 TKR patients from January-2011 to March-2015 were reviewed. Radiological evaluation consisted of assessing the beam angle and the exposure on the images. Implant positioning was also compared by measuring the anatomical axis to look for component alignment discrepancies.Results:The quality of the portable recovery room radiograph was overall inferior to the radiology suite radiograph regarding both beam angle and exposure. Component alignment discrepancies were also identified in the angle measurements between both types of radiographs.Conclusion:Therefore, our study demonstrated that there is no clinical or financial value obtained from postoperative portable radiograph. Furthermore, Immediate recovery room radiographs should be avoided from being performed routinely and may only be used in cases where the surgeon is utilizing a new implant or technique. No external funding was provided for this study from any source.
Clinical and Hematological Profiles of Malaysian Ponies Experimentally Infected with a Field Strain of Trypanosoma evansi
Authors: Elshafie E.I. , Sani R.A. , Sharma R. , Abubakar I.A. 
Published: June 2018

Background:
No outbreak has been reported on Trypanosoma evansi infection in Malaysia ponies since 1983, and little is known about the interaction between T. evansi and ponies in the country. Therefore, an experimental study was designed to evaluate the pathogenicity of a local strain of T. evansi in the local ponies.

Method:
For this purpose, four healthy local ponies were inoculated with 102 live trypanosomes/kg body weight, whereas two ponies served as negative control. Blood samples and rectal temperature were collected on alternate days from both groups for 54 days. Physical examination comprised visible mucous membrane and any appearance of clinical signs were observed daily. The number of trypanosomes was estimated using the Neubauer haemocytometer method. Complete haemogram measurements were performed immediately using an automated blood cell counter and the data obtained was evaluated using the general linear model as linear regression. All infected ponies were salvaged treated with 7 mg/kg of diminazene diaceturate.

Results:
The four infected ponies developed parasitaemia on the 4th day post-infection (DPI), whereas the first high mean of parasites count was recorded on the 8th DPI. Parasitaemia was detected at a level that fluctuated throughout the infection period (30 days) in all infected ponies with a mean of 13.5x106 trypanosomes/ml blood on the 30th DPI. Successive peaks of pyrexia were accompanied by the peaks of parasitaemia and the highest temperature (39.4°C) was observed on the 20th DPI. Excessive weakness and a reduction of appetite fluctuated in the infected ponies during the infection and one animal died unexpectedly on the 23rd DPI. The mean values for RBC, PCV, Hb and thrombocyte count were significantly lower in the infected ponies than the control groups. Neutrophil and eosinophil were significantly declined after the onset of parasitaemia, whereas monocyte increased significantly in the infected group.

Conclusion:
The appearance of clinical signs and changes in haematological parameters suggests that Malaysian local ponies are susceptible to T. evansi infection. Treatment of the infected ponies with the recommended dosage of diminazene diaceturate was successful in the surviving ponies.
Post-exercise Glucose Response Following Whey Protein Ingestion in Healthy Young People: A Randomized Pilot Study
Authors: Kluess Heidi A. , Neidert Leslie E. 
Published: June 2018

Background:
Whey protein may have an effect directly on the muscle to affect exercise glucose response.

Objective:

The study aimed to measure post-exercise glucose recovery with supplementation and the role of DPP-IV and IL-6.

Methods:
Twenty-four participants were randomly assigned to one of three supplementation conditions (CTL: water, WPI: 31g whey protein isolate, and CHO: 32g fructose beverage; WPI and CHO beverages were isocaloric). During the Baseline Visit, participants performed an Oral Glucose Tolerance Test (OGTT) with no exercise or supplementation. On their second and third visits, participants consumed their assigned beverage then completed a maximal treadmill protocol until volitional fatigue. An OGTT was completed on the second visit, and blood samples were collected via venipuncture on the third visit for IL-6, Insulin and DPP-IV.

Results:
Glucose delta peak was attenuated in WPI+exercise by -45±25% and CHO+exercise by -49±21%, compared to baseline (p<0.05). Glucose area under the curve was only attenuated with WPI+exercise (5,993±1,013mg/dl*min), compared to baseline (10,604±4,589mg/dl*min; p<0.05). Insulin was elevated in the WPI+exercise (111±57pmol/L) and CHO+exercise (119±70pmol/L), compared to rest (WPI: 61±40pmol/L; CHO: 78±56pmol/L; p<0.05). IL-6 and DPP-IV activated T-cells (CD26+) were not different among groups. However, plasma DPP-IV was higher in WPI (8±6U/L) compared to CTL (0.7±2U/L) and CHO (0.6±4U/L; p<0.05).

Conclusion:
We found that a single dose of whey protein given prior to exercise results in elevated DPP-IV activity in the plasma and improved glucose response. Together these data suggest that whey protein as a supplement to exercise may be beneficial for humans trying to manage their blood sugar.
[T]errores cotidianos. Hipérbole, caricatura, deformación y otros catalizadores de la invención
Authors: Lus Arana Luis Miguel 
Published: June 2018

<p>Pese a su tradicional codificación como disciplina menor, o degeneración de expresiones artísticas verdaderas, la caricatura ha gozado de una especial atención por parte de los artistas, así como de una reivindicación por parte de la moderna historia del arte. Ernst Hans Josef Gombrich, siguiendo los pasos de Ernst Kris y de historiadores anteriores, encontró en la caricatura el ejemplo paradigmático de la prevalencia del reconocimiento frente al parecido en la representación. Pero además, en lo que tiene de deformación de la realidad, la caricatura tiene una poderosa capacidad de catalizador creativo, cuyo interés para la arquitectura está aún por explorar.</p>
FuckUp Nights. La exhibición del fracaso
Authors: Barroso Olmedo Erandi Paula 
Published: June 2018

<p>hace aproximadamente cinco años, me pareció extrañísimo recibir una invitación para asistir a una sesión destinada a exponer el fracaso profesional de otros. Alrededor de 12 personas nos reunimos, en el patio trasero de una antigua casa de la colonia Roma, con el objetivo de escuchar cómo, paso a paso, y a pesar de todos los esfuerzos por evitarlo, las cosas salieron mal. La valentía, acompañada de cierto grado de vergüenza, de los tres presentadores y la presencia de algunos espectadores fueron suficientes para iniciar las FuckUp Nights, una serie de eventos destinados a compartir historias<br />de fracasos profesionales.</p>
Ciudad neoliberal y políticas de la imagen
Authors: Montes Ruiz Ana Paula 
Published: June 2018

<p>A propósito del proyecto de investigación que desarrollo dentro del Programa de Doctorado de Urbanismo de la unam, el presente artículo propone construir un objeto de estudio que, si bien inscrito en el campo del urbanismo, pueda ser confrontado desde la perspectiva de los estudios de la imagen. Propongo que el avance de la urbanización no puede ser comprendida sólo en el registro político económico que ofrecen la geografía crítica, porque para comprender un tipo de procedimiento de naturaleza visual –comunicacional y estético– afectiva que ha sido incorporado dentro del proceso neoliberal de producción del espacio es pertinente incorporar la dimensión biopolítica.</p>
Notas para una mirada geopolítica a la representación del espacio y los espacios de representación: 3 ejes argumentativos de aproximación
Authors: González Luna Fabián 
Published: June 2018

<p>En el artículo se desarrolla una reflexión desde el espacio como clave epistemológica que busca articular una mirada geopolítica a los fenómenos de las rentas de segregación y cultural, por un lado, y a la justicia espacial por el otro. En específico se ponen en discusión tres tesis o ejes argumentativos, el primero refiere a la geopolítica como una estrategia metodológica que permite considerar a las representaciones espaciales como subjetivaciones dominantes fundamentales en el desarrollo geográfico desigual. El segundo aborda cómo la producción de representaciones espaciales permite producir rentas de segregación y culturales verticalizadas. Por último, se discuten los espacios de representación como posibilidad de justicia espacial.</p>
El trazo sutil amplificado: dibujos de observación en Taller de Arquitectura
Authors: Cañete Islas Omar 
Published: June 2018

<p>Se pretende sistematizar una serie de experiencias docentes que buscan acotar un campo comprensivo respecto del dibujo de observación arquitectural, usualmente conocido como croquis. En un sentido más teórico-pedagógico, se pretende que los alumnos puedan explorar y transitar de modo sensitivo, pero graduado y continuo, entre dos planos: a) la expresión subjetiva y b) la composición formal donde el trazo tiende a abstraer y objetivar y, por ende, organizar y disponer geométricamente lo observado en función de un orden relacional. Pese a sus diferencias (subjetivo vs. objetivo), ambos planos los asumiremos desde un orden generativo, dinámico y complejo.</p>