bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tripartite motif‐containing 37 (TRIM37) promotes the aggressiveness of non‐small‐cell lung cancer cells by activating the NF‐κB pathway
Authors: Li Yun , Deng Liwen , Zhao Xiaohui , Li Bohan , Ren Dong , Yu Lihong , Pan Hehai , Gong Qing , Song Libing , Zhou Xiang , Dai Ting 
Published: July 2018

AbstractNon‐small‐cell lung cancer (NSCLC), in which the NF‐κB pathway is constitutively activated, is one of the most common malignancies. Herein, we identify an E3 ubiquitin ligase, tripartite motif‐containing 37 (TRIM37), participating in the K63 polyubiquitination of TRAF2, which is a significant step in the activation of NF‐κB signaling. Both the mRNA and the protein expression levels of TRIM37 were much higher in NSCLC cell lines and tissues than in normal bronchial epithelial cells and matched adjacent non‐tumor tissues. TRIM37 expression correlated closely with clinical stage and poor survival in NSCLC. Overexpression of TRIM37 antagonized cisplatin‐induced apoptosis, induced angiogenesis and proliferation, and increased the aggressiveness of NSCLC cells in vitro and in vivo, whereas inhibition of TRIM37 led to the opposite effects. Gene set enrichment analysis (GSEA) showed that TRIM37 expression significantly correlated with NF‐κB signaling. Furthermore, we found that TRIM37 bound to TRAF2 and promoted K63‐linked ubiquitination of TRAF2, sustaining the eventual activation of the NF‐κB pathway. Mutation in the ring finger domain of TRIM37, a hallmark of E3 ubiquitin ligases, led to loss of the ability to promote K63 polyubiquitination of TRAF2 and activate NF‐κB signaling. Taken together, our findings provide evidence that TRIM37 plays an important role in constitutive NF‐κB pathway activation and could serve as a prognostic factor and therapeutic target in NSCLC. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Germline mutations in PPFIBP2 are associated with lethal prostate cancer
Authors: Wu Yishuo , Yu Hongjie , Zheng Siqun Lilly , Feng Bingjian , Kapron Ashley L. , Na Rong , Boyle Julie L. , Shah Sameep , Shi Zhuqing , Ewing Charles M. , Wiley Kathleen E. , Luo Jun , Walsh Patrick C. , Carter Herbert Ballentine , Helfand Brian T. , Cooney Kathleen A. , Xu Jianfeng , Isaacs William B. 
Published: July 2018

BackgroundFew genes have germline mutations which predispose men to more aggressive prostate cancer (PCa). This study evaluated the contribution of germline loss of function (LOF) variants in PPFIBP2 to risk of lethal PCa.MethodsA case‐case study of 1414 PCa patients with lethal PCa and low‐risk localized PCa was performed. Germline DNA samples from these patients were sequenced for PPFIBP2. Mutation carrier rates and association with lethal PCa were analyzed using the Fisher exact test, logistic regression, and Kaplan‐Meier survival analysis.ResultsIn the entire study population, eight patients, all of European ancestry, were identified as carrying PPFIBP2 pathogenic or likely pathogenic mutations. Seven (1.52%) of 462 lethal PCa patients were carriers compared with only one (0.12%) carrier in 810 low‐risk PCa patients, P = 0.0029. The estimated Odds Ratio (OR) of carrying PPFIBP2 mutation for lethal PCa was 13.8 in European American population. The PPFIBP2 loss‐of‐function mutation carrier rate in lethal PCa cases was also higher than in 33 370 non‐Finnish European individuals from the Exome Aggregation Consortium (ExAC) (carrier rate of 0.17%, P = 1.92 × 10−5) and in 498 men with localized PCa from The Cancer Genome Atlas cohort (TCGA) cohort (carrier rate of 0%, P = 0.0058). Survival analysis in European American lethal cases revealed PPFIBP2 mutation status as an independent predictor of shorter survival after adjusting for age at diagnosis, PSA at diagnosis, and genetic background (hazard ratio = 2.62, P = 0.034).ConclusionsWhile larger studies are needed, germline mutations in a novel gene, PPFIBP2, differentiated risk for lethal PCa from low‐risk cases and were associated with shorter survival times after diagnosis.
Congestus modes in circulating equilibria of the tropical atmosphere in a two‐column model
Authors: Nuijens Louise , Emanuel Kerry 
Published: July 2018

A two‐column radiative–convective equilibrium (RCE) model is used to study the depth of convection that develops in the subsiding branch of a Walker‐like overturning circulation. The model numerically solves for two‐dimensional non‐rotating hydrostatic flow, which is damped by momentum diffusion in the boundary layer and model interior, and by convective momentum transport. Convection, clouds and radiative transfer are parametrized, and the convection scheme does not include explicit freezing or melting.While integrating the model towards local RCE, the level of neutral buoyancy (LNB) fluctuates between mid‐ and high levels. Evaporation of detrained moisture at the LNB locally cools the environment, so that the final RCE state has a stable layer at mid‐levels (550 hPa ≈ 50–100 hPa below 0 °C), which is unrelated to melting of ice. Preferred detrainment at mid‐ and high levels leaves the middle‐to‐upper troposphere relatively dry.A circulation is introduced by incrementally lowering the sea‐surface temperature in one column, which collapses convection: first to a congestus mode with tops near 550 hPa, below the dry layer created in RCE; then to congestus with tops near 650 hPa; and finally to shallow cumulus with tops near 850 hPa. Critical to stabilizing congestus near 650 hPa is large radiative cooling near moist cumulus tops under a dry upper atmosphere. This congestus mode is very sensitive, and only develops when horizontal temperature gradients created by evaporative and radiative cooling can persist against the work of gravity waves. This only happens in runs with ample momentum diffusion, which are those with convective momentum transport or large domains.Compared to the shallow mode, the congestus mode produces a deep moist layer and more precipitation. This reduces radiative cooling in the cloud layer and enhances stability near the cloud base, which weakens the circulation, and leads to less precipitation over the warm ocean.
Program comprehension through reverse‐engineered sequence diagrams: A systematic review
Authors: Ghaleb Taher Ahmed , Alturki Musab A. , Aljasser Khalid 
Published: July 2018

AbstractReverse engineering of sequence diagrams refers to the process of extracting meaningful information about the behavior of software systems in the form of appropriately generated sequence diagrams. This process has become a practical method for retrieving the behavior of software systems, primarily those with inadequate documentation. Various approaches have been proposed in the literature to produce from a given system a series of interactions that can be used for different purposes. The reason for such diversity of approaches is the need to offer sequence diagrams that can cater for the users' specific goals and needs, which can vary widely depending on the users' perception and understandability of visual representations and the target application domains. In this paper, we systematically review existing techniques in this context while focusing on their distinct purposes and potentials of providing more understandable sequence diagrams. In addition, a qualitative evaluation of such techniques is conducted to expose their adequacy and applicability for effective program comprehension. Finally, we list a set of possible extensions to the unified modeling language sequence diagram standard that we anticipate will enhance its versatility and understandability of program control flow, followed by a number of concluding remarks.
Mesh‐adaptive simulations of horizontal‐axis turbine arrays using the actuator line method
Authors: Deskos Georgios , Piggott Matthew D. 
Published: July 2018

AbstractNumerical models of the flow and wakes due to turbines operating within a real‐scale offshore wind farm can lead to a prohibitively large computational cost, particularly when considering blade‐resolved simulations. With the introduction of turbine parametrizations such as the actuator disk (AD) or the actuator line (AL) models, this problem has been partially addressed, yet the computational cost associated with these simulations remains high. In this work, we present an implementation and validation of an AL model within the mesh‐adaptive three‐dimensional fluid dynamics solver, Fluidity, under a unsteady Reynolds‐averaged Navier‐Stokes–based turbulence modelling approach. A key feature of this implementation is the use of mesh optimization techniques, which allow for the automatic refinement or coarsening of the mesh locally according to the resolution needed by the fluid flow solver. The model is first validated against experimental data from wind tunnel tests. Finally, we demonstrate the benefits of mesh‐adaptivity by considering flow past the Lillgrund offshore wind farm.
Characteristics of Calcium-Aluminate Slags and Pig Iron Produced from Smelting-Reduction of Low-Grade Bauxites
Authors: Azof Fabian Imanasa , Kolbeinsen Leiv , Safarian Jafar 
Published: July 2018

Abstract
Low-grade bauxite ores are not favorable in the conventional Bayer process for alumina production, as they are producing more bauxite residue (red mud) and accompanying lower alumina yield than high-grade ores. In the current study, the thermodynamics and characterization of calcium-aluminate slags and pig iron produced from smelting reduction of high iron- and silica-containing bauxites are studied. Coke and limestone are used to reduce the iron oxide and adjust the basicity of slag during smelting. There is evidence that complete iron separation from bauxite is feasible through smelting-reduction process, and up to 99.9 pct of iron can be eliminated. Moreover, it is shown that the partial separation of silicon, titanium, and other elements from the Al2O3-containing slag occurs. The phase compositions and the distribution of elements between the metal and slag phases provide information about the high-temperature behavior of the bauxite components during smelting reduction. Employing electron microscopy analysis, it is indicated that the morphologies of CaO·Al2O3, 12CaO·7Al2O3, 2CaO·Al2O3·SiO2, and CaO·Al2O3·SiO2 phases in the slag, as well as the complex oxides of Ca-Al-Si-Ti in the slag behave differently as the mass ratio of Al2O3/(Fe2O3 + SiO2) in the bauxite changes. It is also shown that the phases of slag produced from smelting-reduction below 5 K s−1 of cooling rate are proper for further leaching process.
Changing the transmission belt: the programme-to-policy link in Italy between the First and Second Republic
Authors: Carammia Marcello , Borghetto Enrico , Bevan Shaun 
Published: July 2018

AbstractThis article analyses the transmission of policy priorities from electoral campaigns to legislative outputs under different institutional configurations. Taking an agenda-setting approach, the article tests whether a mandate effect exists, if incumbents also uptake the priorities of their competitors, and whether and how the introduction of alternation in government impacts on these dynamics. The analysis relies on data sets of the Italian Agendas Project recording the issue content of party manifestos and laws and covering the period 1983–2012. The results of time series cross-sectional models lend support to the presence of a mandate effect in Italy, a mechanism which was strengthened after the introduction of alternation in government. Opposition priorities may have an impact on the legislative agenda, but mostly when considering the legislation initiated in Parliament. Our findings have important implications for the understanding of the impact of government alternation, an institutional feature underlying – with varying intensity – most democracies, on the functioning of democratic representation.
Acculturation of immigrant diet, basic taste responses and sodium appetite
Authors: Leshem Micah , Dessie-Navon Haymanot 
Published: July 2018

AbstractIn young new Ethiopian immigrants (EI, about 0·5 years since immigration;n20), veteran Ethiopian immigrant students (ES, about 13 years since immigration;n30) and native Israeli students (NS;n82), dietary macronutrients and electrolytes, and responses to basic tastes were compared in a cross-sectional design. From EI, to ES, to NS, dietary energy, protein, fat, and Na+increase, whereas carbohydrates, K+and Ca2+do not differ. Corrected for energy intake, only Na+increases. EI consume less dietary Na+, like foods with less Na+content, salt their food less, yet show a greater hedonic response to salt taste. In contrast, preference for sweet does not differ. Taste psychophysics, 6-n-propylthiouracil (PROP) responses and lingual fungiform papillae density differ by group (and sex), but do not relate to dietary intake. Together, these changes could reflect dietary acculturation, increasing overall intake, Na+in particular, accompanied by decreasing taste sensitivity, and changes in sensory perception and preference in these Ethiopian immigrants. The fact that immigrants find salt more hedonic, yet eat less of it, could suggest increased sensitivity to its taste, and might suggest restoring sensitivity to reduce Na+intake for all. Similar alterations in taste sensory responses might be obtained in other forms of dietary flux. Understanding dietary acculturation can focus efforts (e.g. on Na+), to anticipate the disease burden of diets of affluence among immigrants. Yet, these immigrants’ nutrition is healthier in its low fat and Na+, suggesting that nutritional advice should focus on preservation, as well as prevention. Our study adds Ethiopian nutritional acculturation to that of the varied immigrant groups around the world.
L'Observation Spectroscopique des Couples Visuels
Authors: Dommanget J. 
Published: July 2018

Le concours de diverses techniques d'observation a toujours été profitable au progrès des connaissances astronomiques.Dans le cas des couples stellaires, l'observation visuelle et Fobservation spectroscopique se completent heureusement: chacune d'elles - lorsqu'elles sont possiblesconduit a la connaissance des éléments orbitaux, sauf que la première ne fournit pas l'échelle de Forbite en unités astronomiques et laisse subsister une certaine indetermination, relative á la position du noeud ascendant, et que la seconde n'apporte aucune information sur la valeur de Finclinaison et sur celle de Fangle de position de la ligne des nœuds.
The impact of oil revenues on wellbeing in Chad
Authors: Gadom Gadom Djal , Kountchou Armand Mboutchouang , Araar Abdelkrim 
Published: July 2018

AbstractThis paper uses two recent household surveys, together with data from the College for Control and Monitoring of Oil Revenues, to analyse the impact of oil revenues on wellbeing in Chad. Following a multiple-correspondence analysis to estimate a synthetic household-based multidimensional wellbeing (MDW) index, we used the difference-in-difference approach to assess the impact of oil revenues on average MDW at the department level. We found evidence that departments in Chad that received significant oil transfers have a higher MDW compared to those disadvantaged by the oil-revenue-redistribution policy. We conclude that, in order to promote economic inclusion, the government of Chad should better develop oil-revenue-redistribution policies according to local development needs and target the poorest departments.
Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function
Authors: Hanada Yukiko , Nakamura Yukiko , Ozono Yoshiyuki , Ishida Yusuke , Takimoto Yasumitsu , Taniguchi Manabu , Ohata Kazuya , Koyama Yoshihisa , Imai Takao , Morihana Tetsuo , Kondo Makoto , Sato Takashi , Inohara Hidenori , Shimada Shoichi 
Published: July 2018

AbstractWe investigated fibroblast growth factor 12 (FGF12) as a transcript enriched in the inner ear by searching published cDNA library databases. FGF12 is a fibroblast growth factor homologous factor, a subset of the FGF superfamily. To date, its localisation and function in the inner ear have not been determined. Here, we show that FGF12 mRNA is localised in spiral ganglion neurons (SGNs) and the vestibular ganglion. We also show that FGF12 protein is localised in SGNs, the vestibular ganglion, and nerve fibres extending beneath hair cells. Moreover, we investigated FGF12 function in auditory and vestibular systems using Fgf12-knockout (FGF12-KO) mice generated with CRISPR/Cas9 technology. Our results show that the inner ear morphology of FGF12-KO mice is not significantly different compared with wild-type mice. However, FGF12-KO mice exhibited an increased hearing threshold, as measured by the auditory brainstem response, as well as deficits in rotarod and balance beam performance tests. These results suggest that FGF12 is necessary for normal auditory and equilibrium function.
Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model
Authors: Garcia Ribeiro Rita Sofia , Gysemans Conny , da Cunha João Paulo Monteiro Carvalho Mori , Manshian Bella B. , Jirak Daniel , Kriz Jan , Gallo Juan , Bañobre-López Manuel , Struys Tom , De Cuyper Marcel , Mathieu Chantal , Soenen Stefaan J. , Gsell Willy , Himmelreich Uwe 
Published: July 2018

AbstractMagnetoliposomes (MLs) were synthesized and tested for longitudinal monitoring of transplanted pancreatic islets using magnetic resonance imaging (MRI) in rat models. The rat insulinoma cell line INS-1E and isolated pancreatic islets from outbred and inbred rats were used to optimize labeling conditions in vitro. Strong MRI contrast was generated by islets exposed to 50 µg Fe/ml for 24 hours without any increased cell death, loss of function or other signs of toxicity. In vivo experiments showed that pancreatic islets (50–1000 units) labeled with MLs were detectable for up to 6 weeks post-transplantation in the kidney subcapsular space. Islets were also monitored for two weeks following transplantation through the portal vein of the liver. Hereby, islets labeled with MLs and transplanted under the left kidney capsule were able to correct hyperglycemia and had stable MRI signals until nephrectomy. Interestingly, in vivo MRI of streptozotocin induced diabetic rats transplanted with allogeneic islets demonstrated loss of MRI contrast between 7–16 days, indicative of loss of islet structure. MLs used in this study were not only beneficial for monitoring the location of transplanted islets in vivo with high sensitivity but also reported on islet integrity and hereby indirectly on islet function and rejection.
Genotype determination of the OPN1LW/OPN1MW genes: novel disease-causing mechanisms in Japanese patients with blue cone monochromacy
Authors: Katagiri Satoshi , Iwasa Maki , Hayashi Takaaki , Hosono Katsuhiro , Yamashita Takahiro , Kuniyoshi Kazuki , Ueno Shinji , Kondo Mineo , Ueyama Hisao , Ogita Hisakazu , Shichida Yoshinori , Inagaki Hidehito , Kurahashi Hiroki , Kondo Hiroyuki , Ohji Masahito , Hotta Yoshihiro , Nakano Tadashi 
Published: July 2018

AbstractBlue cone monochromacy (BCM) is characterized by loss of function of both OPN1LW (the first) and OPN1MW (the downstream) genes on the X chromosome. The purpose of this study was to investigate the first and downstream genes in the OPN1LW/OPN1MW array in four unrelated Japanese males with BCM. In Case 1, only one gene was present. Abnormalities were found in the promoter, which had a mixed unique profile of first and downstream gene promoters and a −71A > C substitution. As the promoter was active in the reporter assay, the cause of BCM remains unclear. In Case 2, the same novel mutation, M273K, was present in exon 5 of both genes in a two-gene array. The mutant pigments showed no absorbance at any of the wavelengths tested, suggesting that the mutation causes pigment dysfunction. Case 3 had a large deletion including the locus control region and entire first gene. Case 4 also had a large deletion involving exons 2–6 of the first gene. As an intact LCR was present upstream and one apparently normal downstream gene was present, BCM in Case 4 was not ascribed solely to the deletion. The deletions in Cases 3 and 4 were considered to have been caused by non-homologous recombination.
Single institution analysis of incidence and risk factors for post-mastectomy pain syndrome
Authors: Cui Lingfei , Fan Ping , Qiu Chaoxue , Hong Yong 
Published: July 2018

AbstractPost Mastectomy Pain Syndrome (PMPS) is a common postoperative condition for breast cancer, but has been ignored. The aim of this study was to investigate the prevalence of PMPS and the risk factors in women submitted to surgical treatment for breast cancer. The study included 532 postoperative breast cancer patients in a hospital for five consecutive years period, of whom 473 were considered eligible and included in the study. A total of 420 people completed a questionnaire survey, which revealed that 152 (36.2%) had ever suffered from PMPS and 18 (11.8%) sought treatment. Of the patients with PMPS, 34 (22.4%) had a history of chronic pain. Patients with PMPS were younger than patients without PMPS (50.5 ± 10.4 vs 53.5 ± 11.1). Univariate analysis showed that age, history of chronic pain, tumor staging, number of lymphadenectomy were significantly different between the two groups. Multivariate analysis shows that age and history of chronic pain were independent risk factors. The incidence of PMPS in postoperative breast cancer patients can reach 36.2%, and age as well as previous history of pain are independent risk factors for PMPS. The combination of prevention and treatment may be an effective way to reduce PMPS.
Moderate alcohol drinking is not associated with risk of depression in older adults
Authors: García-Esquinas Esther , Ortolá Rosario , Galán Iñaki , Soler-Vila Hosanna , Laclaustra Martín , Rodríguez-Artalejo Fernando 
Published: July 2018

AbstractThe scarce research on the effects of moderate alcohol consumption on mental health among older adults suggests a protective effect against depression. We prospectively examined the association between patterns of moderate alcohol consumption, depression and psychological distress, using information from 5,299 community-dwelling older adults from the ELSA and Seniors-ENRICA cohorts. A Mediterranean drinking pattern (MDP) was defined as moderate alcohol intake (<40 g/day for men; <24 g/day for women) with a preference for wine and drinking only with meals. Depression was ascertained with the 10-item Geriatric Depression Scale (GDS-10), a self-report of clinically-diagnosed depression, or being on anti-depressant medication (Seniors-ENRICA); and with the 8-item Center for Epidemiologic Studies Depression Scale (CES-D) (ELSA). Psychological distress was assessed with the General Health Questionnaire-12 (GHQ-12). Compared to never drinkers, moderate drinkers showed comparable scores on the ENRICA-GDS-10 (PRR (95%CI): 1.03 (0.84–1.26)), the ENRICA-GHQ-12 (0.88 (0.73–1.06)), the ELSA-CES-D (0.92 (0.79–1.06)) and the ELSA-GHQ-12 (0.75 (0.55–1.01). The MDP was not associated with the GDS-10 or GHQ-12 scores, or with clinically-diagnosed depression; however drinkers with a preference for wine showed an increased number of psychological distress symptoms (1.31 (1.03–1.66)). In conclusion, we found no consistent protective association between moderate alcohol consumption and depression in older adults.