bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of timing of methadone initiation on perinatal outcomes following delivery among pregnant women on methadone maintenance therapy in Ontario
Authors: Guan Qi , Sproule Beth A. , Vigod Simone N. , Cadarette Suzanne M. , Greaves Simon , Martins Diana , Gomes Tara 
Published: October 2018

AbstractBackground and AimsMethadone maintenance therapy (MMT) is associated with improved outcomes for children exposed to maternal opioid dependence in utero. We examined Ontario's population of pregnant women on MMT and determined the impact of timing of MMT initiation on perinatal outcomes.DesignCohort study.SettingOntario, Canada.ParticipantsWomen eligible for public drug benefits and on MMT during pregnancy between 2005 and 2015.MeasurementsWe stratified women based on their timing of MMT initiation: (1) stabilized prior to conception, (2) newly initiated prior to conception, (3) initiation in trimester 1, (4) initiation in trimester 2 or (5) initiation in trimester 3. The primary outcomes in the multivariable logistic regression analysis were key perinatal health indicators: small for gestational age, preterm birth, congenital anomalies, severe maternal morbidity, caesarean section and induced labor. Secondary outcomes were specific to maternal opioid dependence: neonatal abstinence syndrome (NAS), admission to a neonatal intensive care unit (NICU), NAS treatment, removal from mother's custody at hospital discharge and neonatal death.FindingsAmong 1842 women on MMT during pregnancy, 87.6% (n = 1614) initiated MMT before conception. Almost a quarter of their infants (22.2%; n = 408) were born small for gestational age, 17.5% (n = 323) were preterm and 5.9% (n = 109) were born with a congenital anomaly. The odds of primary outcomes occurring did not differ based on timing of methadone initiation; however, infants of mothers who initiated methadone during pregnancy had up to a fourfold increase in the odds of social services removal at the hospital [adjusted odds ratio (aOR) range = 3.70–4.19] compared with those whose mothers were stabilized on MMT prior to conception.ConclusionsLater initiation of methadone maintenance therapy among pregnant women in Ontario, Canada has not been found to be clearly related to most key perinatal adverse health outcomes.
Age‐varying effects of cannabis use frequency and disorder on symptoms of psychosis, depression and anxiety in adolescents and adults
Authors: Leadbeater Bonnie J. , Ames Megan E. , Linden‐Carmichael Ashley N. 
Published: October 2018

AbstractAimsWe tested the age‐varying associations of cannabis use (CU) frequency and disorder (CUD) with psychotic, depressive and anxiety symptoms in adolescent and adult samples. Moderating effects of early onset (≤ 15 years) and sex were tested.DesignTime‐varying effect models were used to assess the significance of concurrent associations between CU and CUD and symptoms of psychosis, depression and anxiety at each age.Setting and ParticipantsAdolescent data (V‐HYS; n = 662) were collected from a randomly recruited sample of adolescents in Victoria, British Columbia, Canada during a 10‐year period (2003–13). Adult cross‐sectional data (NESARC‐III; n = 36 309) were collected from a representative sample from the United States (2012–13).MeasurementsMental health symptoms were assessed using self‐report measures of diagnostic symptoms. CU was based on frequency of past‐year use. Past‐year CUD was based on DSM‐5 criteria.FindingsFor youth in the V‐HYS, CU was associated with psychotic symptoms following age 22 [b = 0.13, 95% confidence interval (CI) = 0.002, 0.25], with depressive symptoms from ages 16–19 and following age 25 (b = 0.17, 95% CI = 0.003, 0.34), but not with anxiety symptoms. CUD was associated with psychotic symptoms following age 23 (b = 0.51, 95% CI = 0.01, 1.01), depressive symptoms at ages 19–20 and following age 25 (b = 0.71, 95% CI = 0.001, 1.42) and anxiety symptoms ages 26–27 only. For adults in the NESARC‐III, CU was associated with mental health symptoms at most ages [e.g. psychotic symptoms; age 18 (b = 0.22, 95% CI = 0.10, 0.33) to age 65 (b = 0.36, 95% CI = 0.16, 0.56)]. CUD was associated with all mental health symptoms across most ages [e.g. depressive symptoms; age 18 (b = 0.96, 95% CI = 0.19, 1.73) to age 61 (b = 1.11, 95% CI = 0.01, 2.21)]. Interactions with sex show stronger associations for females than males in young adulthood [e.g. V‐HYS: CUD × sex interaction on psychotic symptoms significant after age 26 (b = 1.12, 95% CI = 0.02, 2.21)]. Findings were not moderated by early‐onset CU.ConclusionsSignificant associations between cannabis use (CU) frequency and disorder (CUD) and psychotic and depressive symptoms in late adolescence and young adulthood extend across adulthood, and include anxiety.
LncRNAnet: a comprehensive Sus scrofa lncRNA database
Authors: Liang G. , Yang Y. , Li H. , Yu H. , Li X. , Tang Z. , Li K. 
Published: October 2018

SummaryLong noncoding RNAs (lncRNAs) constitute a large class of functional non‐coding RNAs that play important roles in many biological processes. Thousands of lncRNAs have been identified in mammals. Pig is an important farm animal and biomedical model. It is essential to create a Sus scrofa lncRNA database to enable further study of the function and evolution of lncRNAs. In this study, we built a systematic S. scrofa lncRNA database named lncRNAnet that contains 53 468 S. scrofa lncRNAs with their sequence characteristics, genomic locations, conservation, overlapping SNPs and QTLs, and transcript abundance across nine tissues in pigs. We also integrated 212 922 human and mouse lncRNAs sequences into lncRNAnet. This database will provide for a systematic S. scrofa lncRNA classification and help investigators browse, search for and analyze lncRNAs as well as do blast searches among human, mouse and pig lncRNAs. Thus, lncRNAnet should improve the understanding of the biological functions of lncRNA. The database is freely accessible at http://lnc.rnanet.org/.
Genome‐wide association study and heritability estimate for ectopic ureters in Entlebucher mountain dogs
Authors: Gallana M. , Utsunomiya Y. T. , Dolf G. , Pintor Torrecilha R. B. , Falbo A.‐K. , Jagannathan V. , Leeb T. , Reichler I. , Sölkner J. , Schelling C. 
Published: October 2018

SummaryAn ectopic ureter is a congenital anomaly which may lead to urinary incontinence and without a surgical intervention even to end‐stage kidney disease. A genetic component contributes to the development of this anomaly in Entlebucher mountain dogs (EMD); however, its nature remains unclear. Using the Illumina CanineHD bead chip, a case–control genome‐wide association study was performed to identify SNPs associated with the trait. Six loci on canine chromosomes 3, 17, 27 and 30 were identified with 16 significantly associated SNPs. There was no single outstanding SNP associated with the phenotype, and the association signals were not close to known genes involved in human congenital anomalies of the kidney or lower urinary tract. Additional research will be necessary to elucidate the potential role of the associated genes in the development of ectopic ureters in the EMD breed.
Expectations of care within marriage for older couples
Authors: Cash Belinda , Warburton Jeni , Hodgkin Suzanne 
Published: October 2018

ObjectivesThis study explores the intersection of marriage and caregiving amongst older spousal caregivers in regional Australia. Specifically, we address the research question: ‘How do expectations of informal care impact spousal caregivers in later life?’MethodsThese comprise interpretive qualitative in‐depth interviews in order to understand the lived experience of caregiving within the context of long‐term marriage.ResultsFindings highlight the complexity and diversity of marital relationships as the context of informal care. Individual and social obligations were evident in key themes, demonstrating how spouses automatically assume and continue in caregiver roles in later life.ConclusionCaregiving is an expectation of couples in long‐term marriages, regardless of the relationship quality and willingness to care. Normative expectations also impact decision‐making around future care planning and transitions away from home‐based care. These are important considerations for both policy and practice with older adults and their caregivers.
Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments
Authors: Jartti Tuomas , Smits Hermelijn H. , Bønnelykke Klaus , Bircan Ozlem , Elenius Varpu , Konradsen Jon R. , Maggina Paraskevi , Makrinioti Heidi , Stokholm Jakob , Hedlin Gunilla , Papadopoulos Nikolaos , Ruszczynski Marek , Ryczaj Klaudia , Schaub Bianca , Schwarze Jürgen , Skevaki Chrysanthi , Stenberg‐Hammar Katarina , Feleszko Wojciech ,   EAACI Task Force on Clinical Practice Recommendations on Preschool Wheeze
Published: October 2018

AbstractCurrent data indicate that the “bronchiolitis” diagnosis comprises more than one condition. Clinically, pathophysiologically, and even genetically three main clusters of patients can be identified among children suffering from severe bronchiolitis (or first wheezing episode): (a) respiratory syncytial virus (RSV)‐induced bronchiolitis, characterized by young age of the patient, mechanical obstruction of the airways due to mucus and cell debris, and increased risk of recurrent wheezing. For this illness, an effective prophylactic RSV‐specific monoclonal antibody is available; (b) rhinovirus‐induced wheezing, associated with atopic predisposition of the patient and high risk of subsequent asthma development, which may, however, be reversed with systemic corticosteroids in those with severe illness; and (c) wheeze due to other viruses, characteristically likely to be less frequent and severe. Clinically, it is important to distinguish between these partially overlapping patient groups as they are likely to respond to different treatments. It appears that the first episode of severe bronchiolitis in under 2‐year‐old children is a critical event and an important opportunity for designing secondary prevention strategies for asthma. As data have shown bronchiolitis cannot simply be diagnosed using a certain cutoff age, but instead, as we suggest, using the viral etiology as the differentiating factor.
Outcomes following resection of non‐small cell lung cancer in octogenarians
Authors: Vazirani Jaideep , Moraes Johanna , Barnett Stephen , Johnson Douglas F. , Knight Simon , Miller Alistair , Wright Gavin , Alam Naveed Z. , Conron Matthew , Irving Louis B. , Antippa Phillip , Steinfort Daniel P. 
Published: October 2018

BackgroundThe treatment of choice for early stage non‐small cell lung cancer (NSCLC) is surgical resection. Little is known about the short‐ and long‐term outcomes among very elderly patients. We sought to determine predictors of short‐ and long‐term survival among octogenarians undergoing curative‐intent resection for NSCLC in Victoria, Australia.MethodsWe retrospectively reviewed data from all patients aged ≥80 years who underwent curative‐intent resection for NSCLC over 12 years (January 2005–December 2016) across five tertiary centres. We examined effect of age, stage of disease, extent of surgery and lung function on short‐ and long‐term survival.ResultsTwo hundred patients aged ≥80 years underwent curative‐intent resections. Mortality at 30 and 120 days was 2.9% and 5.9%, respectively. Increased early mortality was observed among those ≥83 years, at 30 days (6.8% versus 0.8%, P = 0.044) and 120 days (12.2% versus 2.3%, P = 0.0096). Early mortality was highest among patients ≥83 years requiring lobectomy, compared to sub‐lobar resection at 120 days (17% versus 3.8%, P = 0.019). Long‐term survival was predicted by age and stage of disease. Among patients with Stage I disease aged <83 years, lobectomy was associated with superior 5‐year survival, compared to sub‐lobar resection (83% versus 61%, P = 0.02).ConclusionIn carefully selected elderly patients undergoing curative‐intent resection of early stage NSCLC, both short‐ and long‐term outcomes appear consistent with younger historical cohorts. Early mortality was associated with lobectomy in those with advanced age. Older patients undergoing lobectomy appeared to be at highest risk for early mortality, while younger patients with Stage I disease undergoing at least lobectomy appear to have the best long‐term survival.
Association between lower urinary tract symptoms and cardiovascular risk scores in ostensibly healthy women
Authors: Lee Hyun Young , Moon Ji Eun , Sun Hwa Yeon , Doo Seung Whan , Yang Won Jae , Song Yun Seob , Lee So‐Ryoung , Park Byoung‐Won , Kim Jae Heon 
Published: October 2018

ObjectivesTo investigate the association between lower urinary tract symptoms (LUTS) and cardiovascular disease (CVD) risk in women, as severe LUTS are known to be associated with CVD risk in men but few studies have focused on this issue in women.Subjects and MethodsA total of 1014 ostensibly healthy women, who participated in a voluntary health check in a health promotion centre from November 2013 to October 2015, were enrolled. LUTS were assessed using the International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS). CVD risk scores were calculated using the Framingham risk score and the American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease (ASCVD) score. Correlation, partial correlation, and multiple logistic regression analyses were conducted.ResultsThe mean age and body mass index (BMI) of the women were 51 years and 22.6 kg/m2, respectively. The ASCVD score showed significant positive correlations with IPSS items Question 2 (Q2), Q3, Q5, and Q7 (all P < 0.05), total IPSS (P = 0.001), IPSS storage (P = 0.006) and IPSS voiding symptoms scores (P = 0.001) based on partial correlation analysis after adjustment for BMI. For the OABSS, the ASCVD score showed significant positive correlations with OABSS items Q2, Q3, and Q4 (P < 0.001, P = 0.017, and P < 0.001, respectively) and total OABSS (P < 0.001). Multiple logistic regression analysis showed that the moderate–severe risk groups of the OABSS and IPSS were associated with the ASCVD risk score in adjusted models (P < 0.001) compared to the none–mild OABSS and mild IPSS groups. After adjustment for age and BMI, IPSS storage score was significantly related with the ASCVD risk score (B = 0.855, P = 0.016)ConclusionsLUTS, especially storage symptoms, might be risk factors for predicting future CVD risk in women. Further prospective or cohort studies are needed to validate this possibility.
Relationship between serum level of growth differentiation factors 8, 11 and bone mineral density in girls with anorexia nervosa
Authors: Wu Yali , Qu Jian , Li Huabing , Yuan Haiyan , Guo Qi , Ouyang Zhanbo , Lu Qiong 
Published: October 2018

SummaryBackgroundAdolescents with anorexia nervosa (AN) have low body mass and low bone mineral density (BMD). Growth differentiation factor 8 (Myostatin, GDF8) and its homologue growth differentiation factor 11 (GDF11), members of the TGF‐β super‐family, play an important role in muscle regeneration and bone metabolism in healthy individuals. However, their association with BMD in AN is unknown. The present study was undertaken to investigate the relationship between GDF8, GDF11 and BMD in adolescent girls with AN.MethodsSerum GDF8, GDF11 and BMD were determined in 25 girls (12‐16 years old) with AN and 31 healthy girls (12‐16 years old).ResultsGrowth differentiation factor 8 levels were lower in AN subjects. On the contrary, GDF11 levels were higher in AN subjects than controls. There was no relationship between GDF8 and BMD. A significant negative correlation between GDF11 and BMD was found. In multiple linear stepwise regression analysis, BMI, 25‐hydroxyvitamin D, GDF11, or lean mass, but not fat mass and GDF8, were independent predictors of BMD in the AN and control groups separately.ConclusionsGrowth differentiation factor 11 was independent predictor of BMD in girls with AN. It suggested that GDF11 exerts a negative effect on bone mass.
Analysis of BAFF gene polymorphisms in UK Graves’ disease patients
Authors: Lane Laura C. , Allinson Kathleen R. , Campbell Katy , Bhatnagar Ishita , Ingoe Lorna , Razvi Salman , Cheetham Tim , Cordell Heather J. , Pearce Simon H. , Mitchell Anna L. 
Published: October 2018

SummaryObjectiveB lymphocyte activating factor (BAFF), a member of the tumour necrosis factor superfamily, is essential for B cell activation, differentiation and survival. Elevated circulating BAFF levels have been found in patients with several autoimmune conditions, including Graves’ disease. In addition, BAFF gene variants have been associated with Graves’ disease in a Taiwanese cohort, and with several other autoimmune conditions in non‐Taiwanese populations.Design and methodsWe performed a case‐control association study to investigate two BAFF polymorphisms (rs9514828 and rs4000607) in a UK cohort of 444 patients with Graves’ disease. Genotype frequencies were compared to those from 447 local controls and more than 5000 healthy controls from the Wellcome Trust case‐control consortium (WTCCC2).ResultsThere was a significant difference in the frequency of the AA genotype at rs4000607 between the Graves’ disease cohort and both the local controls (P = 0.045) and the WTCCC2 controls (P = 4.56 × 10−6). Furthermore, the frequency of the A allele was found to be increased in the Graves’ disease group compared to WTCCC2 controls (P = 0.02, OR 1.20 (95% CI 1.03‐1.41). No association was observed at the rs9514828 locus.ConclusionDysfunction of the humoral immune system is an obligatory pathophysiological component of Graves’ disease, hence BAFF is an excellent functional candidate gene. We have demonstrated, for the first time, a significant association of the BAFF polymorphism rs4000607 with Graves’ disease in a UK cohort. Further work to elucidate the role of BAFF in the pathogenesis of Graves’ disease is now warranted.
Recombinant human BMP9 (RhBMP9) in comparison with rhBMP2 for ridge augmentation following tooth extraction: An experimental study in the Beagle dog
Authors: Saulacic Nikola , Schaller Benoit , Muñoz Fernando , Fujioka‐Kobayashi Masako , Kobayashi Eizaburo , Lang Niklaus P. , Miron Richard J. 
Published: October 2018

AbstractObjectivesThe purpose of this study was to compare the effects of rhBMP2 with rhBMP9 on ridge augmentation following healing of extraction sockets in dogs.Material and methodsFive male Beagle dogs, approximately 12 months of age, were used. The mesial roots of the four maxillary premolars were endodontically treated. The distal roots were extracted, and the buccal bony walls removed. All extraction sockets were filled with deproteinized bovine bone mineral (DBBM). A collagen membrane was soaked with 4 μg or 20 μg of rhBMP9, 20 μg of rhBMP2 or sterile saline and placed over the augmented sites. All animals were euthanized after 8 weeks of healing and investigated by micro‐CT and histologic analysis. A one‐way ANOVA with Tukey's HSD post hoc test was used to compare the differences between the four groups.ResultsNew bone apposition in all defects was observed from the original bone. RhBMP samples showed an increase in bone formation in the buccal area and better integration of DBBM particles when compared to control sites. Both rhBMP9 defects showed higher values of bone (p = 0.024), bone marrow (p = 0.044), and total augmentation volume (p = 0.033) than the rhBMP2 (20 μg) or control sites. Highest bone area was found in rhBMP9 defects (p = 0.895).ConclusionsWithin the limitations of the present study, rhBMP9 sites demonstrated higher bone‐inducing potential in combination with DBBM than rhBMP2. While rhBMP9s failed to demonstrate a clear dose‐response relationship to the outcomes, future studies are necessary to evaluate the appropriate dose and carrier systems.
Clinical efficacy of the graft free slit‐window sinus floor elevation procedure: A 2‐year randomized controlled clinical trial
Authors: Ranaan Justin , Bassir Seyed Hossein , Andrada Luciano , Shamshiri Ahmad Reza , Maksoud Mohamed , Raanan Rodney , Guze Kevin 
Published: October 2018

AbstractObjectiveSlit‐window technique is a lateral approach sinus floor elevation (SFE) procedure that utilizes a rigid resorbable membrane in conjunction with stabilizing bony slits to tent the Schneiderian membrane without addition of grafting materials. The aim of this randomized clinical trial was to compare clinical and radiographic outcomes of the Slit‐window SFE with those of SFE with bone grafting.Material and MethodsThirty‐three patients with 38 edentulous sites were included. Edentulous sites were randomly allocated to the Slit‐window SFE or SFE with bone grafting. Simultaneous with SFE, each site received two dental implants. Implant stability quotient (ISQ) values were recorded at baseline and monthly visits for 8 months. The bone coverage and bone height gain at implant sites were recorded on cone beam computed tomography (CBCT) scans 6 and 24 months postoperatively.ResultsThere were no significant differences in the mean ISQ values between the groups at any time point (p > 0.05). All implants in both groups were found to have complete bone coverage. Significant increases in the bone height were found 6 and 24 months postoperatively in both groups (p < 0.001).ConclusionsWithin limitations of the present study, it can be concluded that the Slit‐window SFE technique without the need for bone grafting resulted in sufficient bone height gain around implants placed simultaneous with the SFE procedures. The bone height around these implants was stable during the 2‐year follow‐up period. The treatment outcomes for these implants were comparable to those placed simultaneous with lateral approach SFE in conjunction with bone grafting.
De novo donor‐specific HLA antibodies in heart transplantation: Do transient de novo DSA confer the same risk as persistent de novo DSA?
Authors: Moayedi Yasbanoo , Fan Chun‐Po S. , Tinckam Kathryn J. , Ross Heather J. , McCaughan Jennifer A. 
Published: October 2018

AbstractBackgroundIt is estimated that 25%‐35% of heart transplant recipients develop de novo donor‐specific antibodies (dnDSA). One factor that appears to play a role in clinical outcomes is DSA persistence. The objective of this study was to determine the incidence of transient and persistent dnDSA in a Canadian heart transplant population and to evaluate their impact on coronary allograft vasculopathy (CAV), graft function, and mortality.MethodsA retrospective study of consecutive adult and transitioned pediatric heart transplant recipients (2008‐2015) in Toronto was performed. Clinical demographics were collected prospectively. HLA antibody testing was performed using Luminex single antigen assays. In statistical analysis, dnDSA was modeled as a time dependent covariate.ResultsDuring a median follow‐up of 4.1 years, dnDSA were detected in 42 (23%) with a median time to detection of 329 days (156‐740); 27 (64%) developed persistent dnDSA. Persistent dnDSA conferred an increased risk of death with a HR 4.0 (95%CI 1.4‐12.1) when adjusted recipient age, CAV, and cytomegalovirus status.ConclusionsTransient dnDSA were not associated with adverse outcomes after heart transplantation. This suggests that transient dnDSA may not require enhanced immunosuppression, increased HLA antibody monitoring, or additional physiological assessment. By knowing the transient dnDSA status, clinicians may minimize both recipient morbidity and cost without increasing harm.