bluuebunny/crossref_metadata_2025_split huggingface dataset:
«ОБРАЗОВАТЕЛЬНЫЙ ТУРИЗМ» ПЕТРА I: ВАРВАРСТВО ЯВНОЕ И ЛАТЕНТНОЕ
Authors: О.А. КИРЬЯШ 
Published: November 2024

В статье раскрывается содержание понятия «образовательный туризм», сложившееся в период правления Петра I, прописаны его основные характеристики. Автором представлены приоритетные направления образовательного туризма, имевшие место в начале XVIII в. На материалах писем и путевых заметок представлен собирательный образ студента эпохи Петра I, получавшего образование за границей, который совмещал в себе цивилизационный и варварский компоненты. Ментальная карта студентов XVIII в. претерпела значительные изменения. В ней прослеживается постепенное движение от варварского к цивилизованному восприятию окружающей действительности. Это нашло отражение в появлении новых интеллектуальных конструктов ментальной карты и изменении приоритетов в оценке значимости пространства.
The article reveals the content of the concept of «educational tourism», formed during the reign of Peter I, its main characteristics. The author presents the priority directions of educational tourism that took place in the beginning of XVIII century On the materials of letters and travel notes presents a collective image of the student of the epoch of Peter I, who received education abroad, which combined the civilization and barbarian components. The mental map of students of the XVIII century has undergone significant changes. It traces the gradual movement from barbaric to civilized perception of the surrounding reality. This is reflected in the emergence of new intellectual constructs of the mental map and changing priorities in assessing the importance of space.
ХРИСТИАНСКОЕ КУЛЬТОВОЕ НАСЛЕДИЕ В СОВРЕМЕННОЙ ФРАНЦИИ
Authors: М.К. ЛЮБАРТ 
Published: November 2024

Некогда считавшаяся «старшей дочерью» Католической церкви, Франция сегодня относится к числу стран, где процессы дехристианизации зашли особенно далеко. Получивший печальную известность пожар Собора Парижской Богоматери в апреле 2019 г, —только один из подобных примеров. Количество инцидентов, связанных с христианскими храмами, зарегистрированными полицией, составляет в последнее десятилетие около тысячи в год. Это разграбления, осквернения мест христианского культа, нападения и убийства священников и т.п. Но, кроме того, ежегодно, ряд церквей, признанные не имеющими историко-культурной ценности, сносятся с ведома властей, а некоторые пустующие храмы передаются представителям других религий. Несмотря на протесты (ставших немногочисленными) католических общин и отдельных деятелей политики и культуры, деградация и разрушение храмов не вызывает сколько-нибудь сильной реакции в обществе. Существует целый ряд причин такого положения вещей, коренящихся, вероятно, в идеологических установках неолиберализма, включая особенности преподавания истории, политики лаицизма, нарушения трансмиссии передачи прежних культурных ценностей и т.д.
Once considered the “eldest daughter” of the Catholic Church, France today is one of the countries where the de-Christianization processes have gone especially far. The infamous fire of Notre Dame Cathedral in April 2019 is just one example. The number of incidents related to Christian churches registered by the police in the last decade is about a thousand (!) per year. This is the looting, desecration of places of the Christian cult, the attack and murder of priests, etc. But, in addition, annually, a number of churches, recognized as having no historical and cultural value, are demolished with the knowledge of the authorities, and some empty churches are transferred to representatives of other religions. Despite the protests of the Catholic communities and individual figures of politics and culture, the degradation and destruction of temples does not cause any strong reaction in society. There are a number of reasons for this state of affairs, probably rooted in the ideological principles of neoliberalism, including the peculiarities of teaching history at schools, the politics of laicism, transmission disruptions, the evolution of former cultural values, etc.
Covid Pandemic as a Black Swan Event and Its Impact on World Economies with Special Reference to India
Authors: Pati Dr. Kailash , Pandey Dr. Abhishek Kumar 
Published: November 2024

An event that is not predicted to occur or unexpected events are called black Swans. Such incidents leave an important impression on the economic, political and social sectors. All these events are mainly included under the event of Black Swan such as both World Wars, the fall of the Soviet Union, the rise of Islamic fundamentalists, 9/11,the impact of the spread of the Internet, and the 1987 and 2008 financial crises and Russia Ukraine war so on and so forth. COVID pandemic, which came in 2020, is also included under the phenomenon of Black Swan, about which no one had ever thought. Due to this pandemic, all the economic activities of the world had come to a complete halt for some time. Lockdown was imposed all over the world; people were locked in the four walls of their homes like prisoners. All the modes of transport and fairies were fixed in their places, roads, airports, and railway stations became deserted. Educational institutions and all factories were locked. Due to this pandemic, the condition of the poor became worse and is still the same; the rate of unemployment also increased significantly in the formal and in informal sectors. The people's status declined significantly. Nations also faced economic crisis. This paper is an attempt to undertake an in- depth analysis of Covid pandemic and its worldwide socio-economic effects on different categories of people and different nations. The impact on employment conditions, small- and large-scale production activities, supply chain disruptions, international trade, health and human welfare, social security issues will also be looked into. It will also try to analyze remedial steps taken by different countries and their impact on their respective economies as whole.
Keywords: Pandemic, BlackSwan, Economic activities, Lockdown, Covid
Treated greywater as a novel water resource: The perspective of greywater treatment for reuse from a bibliometric analysis
Authors: Yánez Diana , Espinoza Lidia Carolina , Vargas Ignacio , Romero Julio , Aguirre María Jesús , Arce Roxana , Quijada-Maldonado Esteban , Abejon Ricardo 
Published: November 2024

ABSTRACT
The current global water crisis has prompted research into technologies that can reuse different water resources to mitigate water scarcity. The use of treated greywater can be proposed to provide additional water resources. By reusing this water in different applications, this water crisis can be mitigated at the local scale. This study presents a bibliometric analysis to assess the state of the art of greywater treatment and its reuse technologies. This analysis is based on the scientific literature published until 2023 in Scopus regarding greywater treatment and 1,024 documents were found. The results showed a clear exponential increase in the accumulated number of publications in this topic, which was spurred during the mid-1990s. The most prolific country was the United States, while China, the other typical scientific superpower in most fields, occupied the sixth position in the ranking. Environmental Sciences was the knowledge subject with more documents, followed by Engineering and Chemical Engineering. The bibliometric study was complemented using SciMAT to create bibliometric networks that represent the dynamic evolution of the themes. The most important themes were identified, among which three key points stand out: greywater characterization, technologies for greywater treatment, and water management, including the reuse of treated greywater.
Domain adaptation through active learning strategies for anomaly classification in wastewater treatment plants
Authors: Bellamoli Francesca , Vian Marco , Di Iorio Mattia , Melgani Farid 
Published: November 2024

ABSTRACT

The increasing use of intermittent aeration controllers in wastewater treatment plants (WWTPs) aims to reduce aeration costs via continuous ammonia and oxygen measurements but faces challenges in detecting sensor and process anomalies. Applying machine learning to this unbalanced, multivariate, multiclass classification challenge requires much data, difficult to obtain from a new plant. This study develops a machine learning algorithm to identify anomalies in intermittent aeration WWTPs, adaptable to new plants with limited data. Utilizing active learning, the method iteratively selects samples from the target domain to fine-tune a gradient-boosting model initially trained on data from 17 plants. Three sampling strategies were tested, with low probability and high entropy sampling proving effective in early adaptation, achieving an F2-score close to the optimal with minimal sample use. The objective is to deploy these models as decision support systems for WWTP management, providing a strategy for efficient model adaptation to new plants, and optimizing labeling efforts.
Correlations between SHBG, Sex Hormones, Inflammation, and Neurocognitive Decline in Alzheimer's Disease: A Retrospective Study
Authors: Jin Jiali , Lu Libo , Hua Kaiyao , Fang Ling , Li Xiao , Li Wen 
Published: November 2024

Background:
Alzheimer's Disease (AD) is characterized by a progressive neurodegenerative
process leading to cognitive decline and functional impairment. Endocrine factors, particularly
sex hormones and their binding proteins, play a critical role in AD pathophysiology. Understanding
the relationship between these factors and AD is essential for developing targeted interventions.

Objective:
To investigate the potential links between sex hormone binding globulin (SHBG) levels,
sex hormone profiles, inflammatory markers, and neurocognitive decline in patients with AD.

Methods:
A retrospective case-control investigation was conducted with 110 AD patients who
were admitted to our hospital from January 2021 to December 2023, and the patients were classified
into either a mild neurocognitive impairment group (n=59) or a moderate to severe neurocognitive
impairment group (n=51) according to their cognitive function. Correlation and regression
analyses were conducted to examine relationships between variable factors.

Results:
The study revealed a significant neurocognitive decline in AD patients with lower Mini--
Mental State Examination (MMSE) and higher AD Assessment Scale-Cognitive Subscale (ADAS-
Cog) scores in the moderate to severe neurocognitive impairment group compared to the
mild neurocognitive impairment group. Additionally, the moderate to severe neurocognitive impairment
group significantly increased for SHBG, estradiol, progesterone inflammatory markers
[C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), interleukin-1β
(IL-1β)). It decreased for follicle-stimulating hormone (FSH) and luteinizing hormone (LH)].
Moreover, significant positive correlations were found between SHBG levels and ADAS-Cog
scores, and significant negative correlations were found between SHBG levels and MMSE scores.
FSH showed significant negative correlations with the MMSE score, while certain inflammatory
markers demonstrated significant correlations with neurocognitive abilities. The correlation between
sex hormones and inflammatory factors is weak. FSH, LH, SHBG, CRP, IL-6, TNF-α, and
IL-1β are risk factors for neurocognitive impairment, while E2 and P are protective factors.

Conclusion:
The study provides evidence of significant correlations between SHBG levels, sex
hormone profiles, inflammatory markers, and neurocognitive decline in AD patients.
The Impact of Standardization of Intravenous Medication on Patient Safety and Quality of Healthcare: A Systematic Review
Authors: Alharthi Abdullah , Alshagrawi Salah 
Published: November 2024

Background
Intravenous (IV) drugs are essential in today's healthcare systems for providing patients with accurate and timely therapy in a variety of clinical situations. However, administering IV drugs is intrinsically difficult and fraught with error-proneness, which may seriously compromise patient safety and the standard of medical treatment. One important tactic to reduce these hazards and improve overall patient care is the adoption of standardized procedures for IV drug delivery. This systematic literature review aims to thoroughly investigate and summarize the body of knowledge about the effects of IV drug standardization on patient safety and the caliber of healthcare delivery.

Methods
We used a systematic review approach to examine the impact of standardized intravenous medicine on patient safety and healthcare quality. Guided by the PRISMA framework, we searched articles specifically discussing the standardization of intravenous medication and its implications on patient safety and healthcare quality and related peer-reviewed articles in two major academic databases, PubMed and Google Scholar, based on predetermined eligibility criteria. JBI tool was employed to evaluate the quality of the included studies.

Results
A total of 112 studies were selected from the two major databases, PubMed and Google Scholar, 61 and 51 studies, respectively. After applying the eligibility criteria, 8 studies were finalized for the systematic review. The outcomes showed a variety of clinical settings demonstrate the importance of standardization, and they argue for the maintenance of a focus on the use of standardized procedures in healthcare settings.

Conclusion
The study findings provide compelling evidence in favor of the implementation and ongoing focus on standardized medication concentrations as a critical tactic to enhance patient safety and improve the standard of healthcare. Thus, the creation and use of standardized procedures should be given top priority by healthcare institutions as they advance because they will remain essential to the pursuit of healthcare excellence.
Nanotheranostic Approach for Targeting Tauopathies in Alzheimer's Disease: Mechanistic Insight and Recent Advances
Authors: Sahu Kantrol Kumar , Chaudhary Ruchi , Farooqi Mohd. Asad , Kaurav Monika 
Published: November 2024

aims:
This article first provides an introduction to tauopathy in AD before summarizing current research on the creation of tau-oriented multi-target directed ligands and small compounds as therapies that target tau alteration, aggregation, and degradation.

background:
The most prevalent type of dementia, Alzheimer's disease (AD), is typified by the presence of intracellular tau protein neurofibrillary tangles and extracellular amyloid plaques. There are currently about 50 million people who have dementia, and by 2030, that number is predicted to rise to 75 million, placing a significant financial strain on the nation's healthcare system.

objective:
The overall goal of this work is to present a thorough and critical review of small compounds that are being investigated as potential treatment candidates for AD tauopathy.

method:
Novel disease-modifying treatments are desperately needed to combat this illness, given the consequences on patients' quality of life and the mounting financial strain. There are currently no disease-modifying medications available; instead, the majority of available therapies are symptomatic ones such as cholinesterase inhibitors and N-methyl-D-aspartate receptor blockers.

result:
The primary focus of therapeutic research against AD has shifted to tau-targeting strategies following multiple unsuccessful attempts to create medications against amyloidopathy.

conclusion:
The majority of current pharmacologic research focuses on developing drugs with multiple pharmacological payloads or combining them into a single delivery platform, which may be a promising strategy for completing multiple functions at once. Recent studies have shown that NPs can effectively cross the blood-brain barrier and exhibit inhibitory effects that enhance targeting and effectiveness at specific pH and temperature ranges

other:
As of right now, there isn't an anti-amyloid drug on the market to treat AD. AD may be such a complex disease that a multimodal approach will be needed to stop its progression.
Impact of Remote Symptom Management on Exercise Adherence After Video-Assisted Thoracic Surgery for Lung Cancer in a Tertiary Hospital in China: Protocol for a Prospective Randomized Controlled Trial
Authors: Su Jianwei , Ye Cuiling , Zhang Qian , Liang Yi , Wu Jianwei , Liang Guixi , Cheng Yalan , Yang Xiaojuan 
Published: November 2024

Background
Regular pulmonary rehabilitation exercises are crucial for patients with lung cancer after surgery. However, poor adherence to outpatient exercises is difficult to address due to inadequate supervision. The integration of remote symptom management through electronic patient-reported outcomes (ePROs) offers a potential solution to improve adherence by enabling more effective monitoring and intervention.

Objective
This study aims to evaluate the impact of ePRO-based remote symptom management on enhancing adherence to outpatient pulmonary rehabilitation exercises following video-assisted thoracic surgery for lung cancer.

Methods
In this single-center, prospective, randomized controlled trial, 736 patients undergoing minimally invasive lung resection will be recruited. All patients will use a smartphone app for perioperative management, allowing periodic PRO measurement and recording of exercise participation. Upon discharge, patients will be randomly assigned 1:1 into either an intervention or control group. The intervention group will complete the Perioperative Symptom Assessment for Patients Undergoing Lung Surgery (PSA-Lung) scale on the day of discharge and postdischarge days 3, 7, 14, 21, and 28. Alerts will be triggered at the provider side if any of the 5 core symptoms (pain, cough, shortness of breath, sleep disturbance, and fatigue) scored ≥4, prompting remote symptom management. The control group will complete the PRO measures without triggering alerts. The primary outcome is the rehabilitation exercise adherence rate. Secondary outcomes include postdischarge pulmonary complication rate, 30-day readmission rate, trajectory of symptom severity changes, exercise participation rate, and patient satisfaction.

Results
The enrollment of study participants started in December 2023 and is expected to end in March 2025. The final comprehensive analysis of the results is planned for May 2025, after all data have been collected and thoroughly reviewed.

Conclusions
This study is among the first to investigate the feasibility and effectiveness of ePRO-based remote symptom management in enhancing rehabilitation adherence after video-assisted thoracic surgery for lung cancer. If successful, this approach could significantly influence postoperative care practices and potentially be adopted in similar settings.

Trial Registration
ClinicalTrials.gov NCT05990946; https://clinicaltrials.gov/study/NCT05990946

International Registered Report Identifier (IRRID)
DERR1-10.2196/60420
Ablation of FAM210A in Brown Adipocytes of Mice Exacerbates High-Fat Diet–Induced Metabolic Dysfunction
Authors: Qiu Jiamin , Khedr Mennatallah A. , Pan Meijin , Ferreira Christina R. , Chen Jingjuan , Snyder Madigan M. , Ajuwon Kolapo M. , Yue Feng , Kuang Shihuan 
Published: November 2024

Thermogenesis of brown adipose tissue (BAT) provides metabolic benefits against pathologic conditions, such as type 2 diabetes, obesity, cardiovascular disease, and cancer. The thermogenic function of BAT relies on mitochondria, but whether mitochondrial remodeling is required for the beneficial effects of BAT remains unclear. We recently identified FAM210A as a BAT-enriched mitochondrial protein essential for cold-induced thermogenesis through the modulation of OPA1-dependent cristae remodeling. Here, we report a key role of FAM210A in the systemic response to a high-fat diet (HFD). We discovered that an HFD suppressed FAM210A expression, associated with excessive OPA1 cleavage in BAT. Ucp1-Cre–driven BAT-specific Fam210a knockout (Fam210aUKO) similarly elevated OPA1 cleavage, accompanied by whitening of BAT. When subjected to an HFD, Fam210aUKO mice gained similar fat mass as sibling control mice but developed glucose intolerance, insulin resistance, and liver steatosis. The metabolic dysfunction was associated with overall increased lipid content in both the liver and BAT. Additionally, Fam210aUKO leads to inflammation in white adipose tissue. These data demonstrate that FAM210A in BAT is necessary for counteracting HFD-induced metabolic dysfunction but not obesity.

Article Highlights
FAM210A regulates cold-induced mitochondrial remodeling through control of OPA1 cleavage, but whether it also plays a role in high-fat diet (HFD)–induced cristae remodeling is unknown. We asked if an HFD would alter the FAM210A level and OPA1 cleavage in brown adipose tissue (BAT) and how FAM210A loss of function would affect diet-induced obesity in mice. We found that an HFD diminished FAM210A expression and accelerated OPA1 cleavage in BAT, and Fam210a knockout exacerbated HFD-induced whitening of BAT, cold intolerance, liver steatosis, white adipose tissue inflammation, and metabolic dysfunction. Our work reveals a physiologic role of FAM210A-mediated BAT mitochondrial remodeling in systemic adaptation to an HFD and suggests that BAT mitochondria may be targeted to treat diet-induced metabolic dysfunction.
Can Fiber-reinforced Composites Increase the Fracture Resistance of Direct Composite Restorations in Structurally Compromised Teeth? A Systematic Review and Meta-analysis of Laboratory Studies
Authors: Bijelic-Donova J , Bath AK , Rocca GT , Bella E di , Saratti CM 
Published: November 2024

SUMMARY

Objective:
Systematic review and meta-analysis on laboratory studies aimed to answer whether there is a difference in fracture resistance and fracture mode of structurally compromised teeth restored with direct composite restorations reinforced with short glass-fiber or bidirectional polyethylene fiber substructure, and between the two different fiber-reinforcement types.

Methods:
An electronic literature search was conducted in Medline, Scopus, Web of Science, Lilacs, Google Scholar, Cochrane Library, and University Library databases. The last search was conducted on 16 November 2023. Only studies looking at Ribbond-reinforced restorations and/ or the use of EverX Posterior within restorations were included. Data were categorized and analyzed based on specific outcome measures including fracture resistance and fracture mode. Data from individual studies were divided into premolars and molars for each material category and then collated to compare the mean differences in fracture resistance between control groups (composite restorations) and intervention groups (fiber-reinforced composite restorations).

Results:
From the initial 1266 articles identified, 23 laboratory-based studies were included for quantitative analysis. Twenty articles had an overall low risk of bias and 3 had an overall unclear risk of bias. The pooled estimate of the effect favored the intervention groups as having statistically significant higher fracture resistance when compared to control groups.

Conclusions:
Both fiber types improve fracture resistance and the fracture mode of structurally compromised teeth is equally efficient. Application technique deserves attention. Ribbond could be placed in a single layer at the cavity floor, whereas EverX Posterior should replace missing dentin in an anatomically shaped way.