bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Presentation, Quality of Care, Risk Factors and Outcomes in Women with Acute ST-Elevation Myocardial Infarction (STEMI): An Observational Report from Six Middle Eastern Countries
Authors: Shehab Abdulla , AlHabib Khalid F. , Bhagavathula Akshaya S. , Hersi Ahmad , Alfaleh Hussam , Alshamiri Mostafa Q. , Ullah Anhar , Sulaiman Khadim , Almahmeed Wael , Al Suwaidi Jassim , Alsheikh-Ali Alwai A. , Amin Haitham , Al Jarallah Mohammed , Salam Amar M. 
Published: March 2018

Background:Most of the available literature on ST-Elevated myocardial infarction (STEMI) in women was conducted in the developed world and data from Middle-East countries was limited.Aims:To examine the clinical presentation, patient management, quality of care, risk factors and inhospital outcomes of women with acute STEMI compared with men using data from a large STEMI registry from the Middle East.Methods:Data were derived from the third Gulf Registry of Acute Coronary Events (Gulf RACE-3Ps), a prospective, multinational study of adults with acute STEMI from 36 hospitals in 6 Middle-Eastern countries. The study included 2928 patients; 296 women (10.1%) and 2632 men (89.9%). Clinical presentations, management and in-hospital outcomes were compared between the 2 groups.Results:Women were 10 years older and more likely to have diabetes mellitus, hypertension, and hyperlipidemia compared with men who were more likely to be smokers (all p<0.001). Women had longer median symptom-onset to emergency department (ED) arrival times (230 vs. 170 min, p<0.001) and ED to diagnostic ECG (8 vs. 6 min., p<0.001). When primary percutaneous coronary intervention (PPCI) was performed, women had longer door-to-balloon time (DBT) (86 vs. 73 min., p=0.009). When thrombolytic therapy was not administered, women were less likely to receive PPCI (69.7 vs. 76.7%, p=0.036). The mean duration of hospital stay was longer in women (6.03 ± 22.51 vs. 3.41 ± 19.45 days, p=0.032) and the crude in-hospital mortality rate was higher in women (10.4 vs. 5.2%, p<0.001). However, after adjustments, multivariate analysis revealed a statistically non-significant trend of higher inhospital mortality among women than men (6.4 vs. 4.6%), (p=0.145).Conclusion:Our study demonstrates that women in our region have almost double the mortality from STEMI compared with men. Although this can partially be explained by older age and higher risk profiles in women, however, correction of identified gaps in quality of care should be attempted to reduce the high morbidity and mortality of STEMI in our women.
Voltammetric Sensors Based on Various Nanomaterials for the Determination of Sulfonamides
Authors: Beigizadeh Hana , Ganjali Mohammad Reza , Norouzi Parviz 
Published: March 2018

Background:The widespread applications of sulphonamides, as antibacterial or antimicrobial agents, and their mechanism of actions in the body, have changed their determination to an important issue in the area of human health.Objective:Here, history of developing voltammetric sensors based on nanomaterials for the detection of sulfonamides including sulfadiazine, sulfamethoxazole, sulfacetamide, sulfadimethoxine, sulfathiazole, sulfamethiazole and sulfamerazine is reviewed. Modified electrodes based on various nanomaterials (carbonaceous nanomaterials, Metallic Nanoparticles (MNPs), conducting nanopolymers) have been reported, and studies showed that nanomaterials have been mostly used to overcome problems like the poor sensitivity and selectivity of bare electrodes. The study covers the properties of each sensor in detail, and reports and compares the linear ranges, Limits of Detection (LODs), reproducibility, and reusability of the electrodes reported so far.
Apoptosis Caused by Triterpenes and Phytosterols and Antioxidant Activity of an Enriched Flavonoid Extract from Passiflora mucronata
Authors: da Silva Isabel C.V. , Kaluđerović Goran N. , de Oliveira Pollyana F. , Guimarães Denise O. , Quaresma Carla H. , Porzel Andrea , Muzitano Michelle F. , Wessjohann Ludger A. , Leal Ivana C.R. 
Published: March 2018

Background:
P. mucronata (Pm) comes from South America, Brazil and is characterized as “Maracujá
de Restinga”. It is used in folk medicine for its soothing properties and in treating insomnia.

Objective:
The present study for the first time analyzed the antioxidant and cytotoxicity of the hydroalcoholic
leaves extract and fractions from Pm.

Method:
The cytotoxicity test will be evaluated by different assays (MTT and CV) against human prostate cancer
(PC3) and mouse malignant melanoma (B16F10) cell lines, and the antioxidant test by DPPH method.

Results:
β-Amyrin, oleanolic acid, β-sitosterol and stigmasterol were isolated of the most active, hexane fraction.
These substances were tested against the tumor cell lines: β-sitosterol and stigmasterol showed the most
relevant activity to PC3 in CV assay and, oleanolic acid to B16F10 by the MTT assay. In addition, it was possible
to indicate that the mode of cell death for stigmasterol, presumably is apoptosis. In terms of antioxidant
activity, the hydroalcoholic leaves extract presented higher activity (EC50 133.3 µg/mL) compared to the flower
(EC50 152.3 µg/mL) and fruit (EC50 207.9 µg/mL) extracts. By the HPLC-MS, it was possible to identify the
presence of flavones in the leaf extract (isoschaftoside, schaftoside, isovitexin, vitexin, isoorientin, orientin).

Conclusions:
P. mucronata hexane fraction showed promising cytotoxic effect against cancer cell lines, and
stigmasterol contributes to this activity, inducing apoptosis of these cells. Furthermore, as other Passiflora species,
Pm extract showed antioxidant activity and flavones are its major phenolic compounds.
Green Synthesis of Cobalt Oxide Nanoparticles by a Starch-Assisted Method
Authors: Vaya D. , Meena  , Das B.K. 
Published: March 2018

Background:
The properties of the material are altered when material size shifted towards
nano-regime. This feature could be used for wastewater treatment process using model pollutant such as
dyes. Recently, nanoparticles are synthesized by a green chemical route using different capping agents.
This is the reason we adopt starch as green capping agent along with sol-gel method.

Objective:
To synthesize cobalt oxide nanoparticles by green chemical route and utilized it in degradation
of dyes.

Methods:
Synthesis of cobalt oxide nanoparticles by sol-gel method using starch as a capping agent.
The characteristics of surface modifications were investigated by UV-VIS, TEM, SEM, XRD and FTIR
techniques.

Results:
Cobalt oxide nanoparticles synthesized and inhibited photocatalytic activity.

Conclusion:
Deactivation of photocatalytic activity due to complex nature of starch. This property can
be used elsewhere as in light shielding applications to coat and protect surfaces in order to keep them
cool and safe from damage as in the painting of vehicles, roofs, buildings, water tanks, etc.
As contribuições do movimento quilombola para a construção de uma proposta de educação específica
Authors: Moreira Agda Marina Ferreira , Brito José Eustáquio de 
Published: March 2018

Os processos educativos e de formação político-identitários reproduzidos no interior de cada comunidade remanescente de quilombo, juntamente com as experiências advindas dos movimentos sociais quilombolas, são aspectos indispensáveis na discussão de implementação de uma modalidade escolar quilombola. Partindo de um estudo de caso, apresentaremos resultados das observações oriundas da comunidade quilombola de Carrapatos da Tabatinga e do movimento quilombola mineiro, bem como da pesquisa de dissertação de mestrado em Educação e da trajetória profissional na ONG Cedefes e na N’Golo. Para tanto, utilizamos por método a observação participantes, além de trechos de entrevistas centradas no problema, realizadas no campo de pesquisa. Dentre os resultados apresentados, buscaremos enfatizar as formas de se educar construídas nas trocas cotidianas e nas interações com as mobilizações políticas, sendo ambas importantes produtoras de pedagogias próprias, que se relacionam diretamente às reinvindicações e aos aspectos tradicionais presentes nas comunidades quilombolas, sendo parte de uma cosmovisão africana. Em constante diálogo, comunidades e movimento nos instigam a reconhecer formas alternativas de formação de sujeitos engajados, que se reconhecem enquanto quilombolas e que são responsáveis diretos pela preservação dos saberes-fazeres construídos nos espaços de suas respectivas comunidades.
Enfermería Universitaria: 15 años de contribuir a la difusión de la investigación de enfermería
Authors: García-Cardona M. , Cruzaley-Castro I.D. 
Published: March 2018

La revista en su evolución y con la constante mejora en la calidad del proceso editorial ha logrado consolidarse y adquirir reconocimiento, de tal forma que en la actualidad está incluida en ocho bases de datos, entre estas, las tres principales de América Latina: La Biblioteca Virtual en Salud Regional, Scielo y Redalyc, en las dos últimas es la única revista de enfermería de México. En 2016 obtiene otro reconocimiento importante, al ser incluida en el Sistema de Clasificación de Revistas Mexicanas de Ciencia y Tecnología del Consejo Nacional de Ciencia y Tecnología de nuestro país. Estos datos están íntimamente relacionados con la visibilidad y difusión alcanzada, por ejemplo, durante 2017 el número de visitas al sitio de la revista, sólo en la base de datos Scielo, fue de 481 mil, lo que equivale a 1317 visitas por día.
Celebrar estos 15 años de permanencia, es motivo para realizar un recuento de lo publicado e identificar el tipo de artículos; los diseños utilizados en los artículos de investigación; cuáles son las áreas de interés, qué poblaciones de estudio son prioritarias para enfermería; y, finalmente cuál es la procedencia de los autores.
A questão socioambiental na particularidade brasileira: caráter destrutivo da acumulação capitalista
Authors: Nunes Letícia Soares 
Published: March 2018

O objetivo do artigo é problematizar as estratégias do capital para minimizar as sequelas da destrutividade socioambiental. Parte-se do pressuposto que tais estratégias vêm sendo utilizadas como forma de disseminar a ideologia hegemônica de que seria possível compatibilizar sustentabilidade social, ambiental e econômica no capitalismo que, por essência, é destrutivo e desigual. Assim sendo, considerando a pesquisa bibliográfica efetuada na tese de doutoramento, discorre-se neste artigo sobre as contradições do capitalismo que produz de forma ilimitada, mercantiliza a natureza e coisifica o homem, bem como enfatiza-se que a gestão ambiental pública brasileira vem estabelecendo estratégias que estão submetidas à mesma lógica do capital para obtenção de lucro, não interferindo nas causas da crise.
Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody–Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles
Authors: Balke Else M. , Balti Eric V. , Van der Auwera Bart , Weets Ilse , Costa Olivier , Demeester Simke , Abrams Pascale , Casteels Kristina , Coeckelberghs Marina , Tenoutasse Sylvie , Keymeulen Bart , Pipeleers Daniel G. , Gorus Frans K. ,   the Belgian Diabetes Registry
Published: March 2018

OBJECTIVE
We investigated the effect of HLA class I risk alleles on disease progression in various phases of subclinical islet autoimmunity in first-degree relatives of patients with type 1 diabetes.

RESEARCH DESIGN AND METHODS
A registry-based group of siblings/offspring (aged 0–39 years) was monitored from single- to multiple-autoantibody positivity (n = 267) and from multiple-autoantibody positivity to clinical onset (n = 252) according to HLA-DQ, -A*24, -B*18, and -B*39 status. Genetic markers were determined by PCR sequence-specific oligotyping.

RESULTS
Unlike HLA-B*18 or -B*39, HLA-A*24 was associated with delayed progression from single- to multiple-autoantibody positivity (P = 0.009) but not to type 1 diabetes. This occurred independently from older age (P &lt; 0.001) and absence of HLA-DQ2/DQ8 or -DQ8 (P &lt; 0.001 and P = 0.003, respectively), and only in the presence of GAD autoantibodies. In contrast, HLA-A*24 was associated with accelerated progression from multiple-autoantibody positivity to clinical onset (P = 0.006), but its effects were restricted to HLA-DQ8+ relatives with IA-2 or zinc transporter 8 autoantibodies (P = 0.002). HLA-B*18, but not -B*39, was also associated with more rapid progression, but only in HLA-DQ2 carriers with double positivity for GAD and insulin autoantibodies (P = 0.004).

CONCLUSIONS
HLA-A*24 predisposes to a delayed antigen spreading of humoral autoimmunity, whereas HLA-A*24 and -B*18 are associated with accelerated progression of advanced subclinical autoimmunity in distinct risk groups. The relation of these alleles to the underlying disease process requires further investigation. Their typing should be relevant for the preparation and interpretation of observational and interventional studies in asymptomatic type 1 diabetes.
Does the Use of a “Walking Bleaching” Technique Increase Bone Resorption Markers?
Authors: Bersezio C , Vildósola P , Sáez M , Sánchez F , Vernal R , Oliveira OB , Jorquera G , Basualdo J , Loguercio A , Fernández E 
Published: March 2018

SUMMARY

Objective:
This randomized clinical trial evaluated the effect of 35% hydrogen peroxide in comparison with 37% carbamide peroxide in a nonvital bleaching technique of “walking bleaching” (four sessions of treatment) on periodontal markers: nuclear factor kappa B-ligand (RANK-L—process of root resorption marker) and interleukin 1β (IL-1β—inflammatory response marker).

Methods and Materials:
Fifty volunteers presenting with discoloration of nonvital teeth and endodontic treatment in good condition participated. Fifty teeth were randomly divided into two study groups according to bleaching gel: HP = 35% hydrogen peroxide (n=25) and 37% carbamide peroxide (n=25). Nonvital bleaching was performed with a walking bleaching technique consisting of four sessions of bleach application. Gingival crevicular fluid samples were taken in order to quantify the RANK-L and IL-1β levels by enzyme-linked immunosorbent assay. Samples were obtained from six periodontal sites for each bleached tooth: three vestibular and three palatine (mesial, middle, and distal) at seven time periods: baseline, after each of the four sessions of nonvital bleaching, at one week, and at one month after nonvital bleaching. Tooth color variations were analyzed in each session by VITA Bleachedguide 3D-MASTER (ΔSGU).

Results:
Significant increments in the RANK-L and IL-1β levels were detected in each evaluated time compared with baseline (p&lt;0.05); however, no differences were detected between hydrogen peroxide and carbamide peroxide on increments of the biomarkers studied. The change of color was effective for both nonvital bleaching therapies (p&lt;0.05).

Conclusions:
Nonvital bleaching induced a significant increment in the RANK-L and IL-1β levels in periodontal tissues around bleached, nonvital teeth.
Five-year Clinical Evaluation of a Nanofilled and a Nanohybrid Composite in Class IV Cavities
Authors: Demirci M , Tuncer S , Sancakli HS , Tekçe N , Baydemir C 
Published: March 2018

SUMMARY
The purpose of this study was to evaluate a nanofilled and a nanohybrid composite, in combination with manufacturer-recommended etch-and-rinse adhesives, in class IV cavities. Thirty-four patients aged 14-46 years (mean age, 27.1 years) comprised the study group. Twenty-six patients received two class IV restorations and eight patients received four class IV restorations. For each patient, half the number of restorations were performed using a nanohybrid composite (Ceram X duo) and the remaining half used a nanofilled resin composite (Filtek Supreme XT), with two- (XP Bond) and three-step (Scotchbond Multipurpose) etch-and-rinse adhesives, respectively. Two experienced examiners evaluated the restorations for retention, color match, marginal discoloration, wear/loss of anatomic form, caries formation, marginal adaptation, and surface texture to compare the baseline (after placement) and annual recalls over 5 years. The cumulative success rates for the Filtek Supreme XT and Ceram X duo restorations after five years were 86.2% and 89.7%, respectively. Four Filtek Supreme XT and three Ceram X duo restorations failed. There was no statistically significant difference between the nanofilled and nanohybrid composites at any of the evaluation periods for any of the parameters evaluated. Despite the limited number of restorations, all restorations were clinically acceptable regarding retention, color match, marginal discoloration, wear or loss of anatomic form, the formation of caries, marginal adaptation, and surface texture, except the failed restorations. Fracture was the main cause of restoration failure.
INTERNET DAS COISAS NA EDUCAÇÃO: ESTUDO DE CASO E PERSPECTIVAS
Authors: Tavares Sérgio , Tori Romero , Kofuji Sergio Takeo , Marcellos Lincoln , Beingolea Garay Jorge Rodolfo 
Published: March 2018

Com a presença da Internet na vida das pessoas evidenciou-se uma significativa mudança comportamental. As pessoas comunicam-se, trabalham, relacionam-se e aprendem de modo totalmente diferente. A inovação tecnológica acaba por facilitar o acesso à informação através de um número cada vez maior de dispositivos, assim como também traz consigo uma demanda cada vez maior por pessoas com boa formação educacional, capazes de gerar competências e habilidades de um profissional com perfil mais crítico, flexível, dinâmico e que esteja em formação contínua durante a vida toda. Os mais diversos modelos pedagógicos procuram-se adaptar a esta diversidade de informações, dispositivos e tecnologias conhecidas como Internet das coisas (IoT) com o intuito de estabelecer novas formas de conhecimento e aprendizado. Este artigo apresenta uma experiência de aprendizado que integra o método BYOD ao cenário de IoT. Os resultados obtidos evidenciam uma clara aceitação da tecnologia de IoT dentro do processo de ensino.
LEFT SUBCLAVIAN ARTERY RUPTURE DUE TO BLUNT THORACIC TRAUMA: A CASE REPORT
Authors: Habibie Yopie Afriandi , Wuryantoro Ign 
Published: March 2018

Abstrak. Trauma tumpul toraks memiliki insiden yang sangat tinggi pada populasi dewasa, 20 – 50 % dari kasus dapat mengakibatkan kematian. Cedera pada struktur pembuluh darah dari bagian dada atas, terutama pembuluh darah arteri subklavia kiri, sangat jarang ditemukan dan biasanya disertai dengan “hematotoraks massif”. Observasi ketat dari tanda- tanda vital dan foto toraks serial sangatlah penting. Kami paparkan sebuah kasus jarang dari seorang pasien yang mengalami cedera traumatik arteri subklavia kiri. Tidak ditemukan gambaran klinis dari hematoma di supra klavikula, pulsasi arteri radialis kiri tidak teraba, dan tidak ditemukan pelebaran dari mediastinum pada foto toraks. Tetapi didapatkan hematotoraks massif kiri. Dilakukan posterolateral torakotomi kiri, dijumpai sumber perdarahan dari bagian apex paru kiri, dicurigai terdapatnya robekan dari pembuluh darah arteri subklavia kiri. Tindakan dilanjutkan dengan insisi median sternotomy yang diperluas ke arah supraklavikula kiri, ditemukan rupture total dari arteri subklavia kiri dengan jarak 1,5 cm proksimal dari arkus aorta. Tindakan repair (perbaikan) arteri secara primer (end to end anastomosis) dilakukan dengan hasil baik. (JKS 2017; 2: 105-114)Kata kunci : Trauma tumpul toraks, hematotoraks massif, cedera arteri subklavia kiriAbstract. Blunt thoracic trauma highest incidence is in adult, 20% to 50 % of the trauma cause death. Injuries to the vascular structures of the thoracic outlet, especially left subclavian artery, are rare and typically accompanied by massive hemorrhage. Close observation of vital sign and serial chest x-ray are very important. We describe an unusual presentation of a patient who suffered traumatic rupture of left subclavian artery. No clinical presentation of supraclavicular hematoma, unilateral absence of radial artery pulse and mediastinal widening in chest x-ray was found, but there is a massive hemothorax. Left posterolateral thoracotomy was performed, the source of bleeding was found in the apex of the lung, suspected a rupture of the left subclavian artery. The procedure continued with median sternotomy extended to left supraclavicular incision, a rupture was found in the left subclavian artery, 1,5 cm proximal to aortic arch. Primary repair was done with a good result. (JKS 2017; 2: 105-114)Key Words : Blunt thoracic trauma, massive hemothorax, left subclavian artery rupture
DUA KASUS ACQUIRED PROTHROMBIN COMPLEX DEFICIENCY DENGAN PERDARAHAN INTRAKRANIAL : LAPORAN KASUS
Authors: Ismy Jufitriani 
Published: March 2018

Abstrak. Acquired Prothrombin Complex Deficiency (APCD) merupakan perdarahan spontan yang disebabkan oleh penurunan aktivitas faktor koagulasi yang tergantung vitamin K (faktor II, VII, IX dan X), sedangkan aktivitas faktor koagulasi lain, kadar fibrinogen dan jumlah trombosit masih dalam batas normal. Insiden tertinggi APCD pada anak usia 3 – 8 minggu. Dilaporkan 2 kasus APCD di RS Zainoel Abidin Banda Aceh dengan hasil CT-Scan tampak adanya perdarahan Subaracnoid haemorhagic, Subdural haemorhagic, Intracranial Haemorhagic dan Edema cerebri. Pasien mengalami penyembuhan tanpa dilakukan intervensi bedah.Kata kunci : Acquired Prothrombin Complex Deficiency , vitamin K, Perdarahan Subaracnoid haemorhagic, Subdural haemorhagic, Intracranial Haemorhagic AbstractAcquired Prothrombin Complex Deficiency (APCD) is a spontaneous haemorrhage caused by decreased vitamin K-dependent coagulation factor activity (factor II, VII, IX and X), while other coagulation factor activity, fibrinogen levels and platelet counts are within normal limits. Highest incidence of APCD at age 3 - 8 weeks. Reported 2 cases of APCD in RS Zainoel Abidin Banda Aceh with CT-Scan result seen bleeding Subaracnoid haemorhagic, Subdural haemorhagic, Intracranial Haemorhagic and Edema cerebri. The patient is healed without surgical intervention.Key words : Acquired Prothrombin Complex Deficiency, child, vitamin K, Subaracnoid haemorhagic, Subdural haemorhagic, Intracranial Haemorhagic
MORBUS HANSEN Biokimia dan Imunopatogenesis
Authors: Hajar Sitti 
Published: March 2018

Abstrak.Penyakit kusta adalah penyakit yang setua peradaban manusia.telah lama diketahui dan ditulis dalam kitab-kitab kuno. Dalam kitab Sushrat Samhita di zaman India Kuno (1300 SM), tercantum adanya penyakit yang disebut khust dengan deskripsi sesuai dengan kusta serta tulisan pada daun Papyrus di Mesir, tercantum hal mengenai penyakit yang sesuai dengan kusta yang dikenal saat ini. Istilah lepra sendiri berasal dari bahasa Yunani kuno dalam Kitab Perjanjian Baru, merupakan terjemahan dari istilah zaraath dari bahasa Ibrani kuno.Mikobakterium lepra memetabolisme sumber-sumber karbon melalui jalur klasik dari glikolisis, hexose monophosphat shunt dan siklus tricarboxylic acid.Respon yang terjadi akibat infeksi M. Lepra dapat sangat berbeda, keadaan ini terjadi di bawah kontrol secara genetika.Kata sandi: Morbus Hansen. Mikobakterium Lepra, ImunopatogenesisAbstract.Abstract Leprosy is a disease that is as old as human civilization. has long been known and written in ancient books. In the book of Sushrat Samhita in Ancient India (1300 BC), there is a disease called khust with description according to the leprosy known today. In the ancient on the leaves of the Papyrus in Egypt,. The term leprosy itself comes from the ancient Greek in the New Testament, a translation of the zaraath term from ancient Hebrew. M.leprae metabolizes carbon sources through the classical pathway of glycolysis, hexose monophosphate shunt and tricarboxylic acid cycles. The response that occurs as a result of Mycobacterium leprae infection can be very different, this situation occurs under genetic control.Password: Morbus Hansen. Mycobacteria Leprae, Immunopathogenesis.