bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beliefs about sharing illness experiences: Development of a scale and relationship with symptoms of fibromyalgia
Authors: Wroe Abigail L. , Bowers Hannah M. 
Published: June 2019

ObjectivesThe aim of the current research was to evaluate, in people with fibromyalgia, the extent to which beliefs about sharing illness experiences are associated with functioning and distress, and to explore the mediating role of illness behaviours. A new scale was designed to address this.DesignThe Beliefs about Sharing Illness Experiences (BASIE) scale was developed, and initial tests of reliability and validity were conducted. A cross‐sectional design was used to determine relationships, including mediation analyses.MethodsIndividuals with fibromyalgia (n = 147) and a comparison group of individuals without fibromyalgia (n = 47) completed questionnaires online. Construct validity was assessed by comparing these two groups. Convergent validity was assessed through correlations with the BASIE and measures of support‐seeking and self‐sacrifice. Correlation analyses were used to determine relationships with illness behaviours and outcome measures (distress and global impact). Mediation analyses were used to test the indirect effects of illness behaviours.ResultsThe BASIE was correlated with expected convergent measures and had good internal consistency (Cronbach's alpha = .939). Individuals with fibromyalgia had significantly higher scores than the comparison group. There was a direct relationship between BASIE scores and outcomes, in terms of functioning and distress. The relationship between BASIE scores and functioning was partially mediated by personal/emotional support‐seeking and all‐or‐nothing behaviours, and not by symptom‐related support‐seeking or limiting behaviours.ConclusionBeliefs about sharing illness experiences may be a key factor in maintaining cycles of distress and symptoms in people with fibromyalgia, together with all‐or‐nothing behaviours and personal/emotional support‐seeking.
Statement of contribution

What is already known on this subject?

Maintenance of fibromyalgia is likely to be a complex autopoietic relationship including symptoms, beliefs, behaviours, and emotions.

Research suggests possible roles of beliefs about unacceptability of emotions and beliefs around interpersonal situations, and behaviours in social situations as well as limiting and all‐or‐nothing behaviours.

People with fibromyalgia may experience stigma, sometimes resulting in secrecy around their condition and symptoms.

What does this study add?

The BASIE is a 21‐item questionnaire that measures beliefs around sharing illness experiences.

Individuals with fibromyalgia hold stronger beliefs around unacceptability of sharing illness experiences.

These beliefs are related to functioning and distress, partially mediated by illness behaviours.
The role of the gasotransmitter hydrogen sulfide in pathological calcification
Authors: Castelblanco Mariela , Nasi Sonia , Pasch Andreas , So Alexander , Busso Nathalie 
Published: June 2019

Calcification is the deposition of minerals, mainly hydroxyapatite, inside the cell or in the extracellular matrix. Physiological calcification is central for many aspects of development including skeletal and tooth growth; conversely, pathological mineralization occurs in soft tissues and is significantly associated with malfunction and impairment of the tissue where it is located. Various mechanisms have been proposed to explain calcification. However, this research area lacks a more integrative, systemic, and global perspective that could explain both physiological and pathological processes. In this review, we propose such an integrated explanation. Hydrogen sulfide (H2S) is a newly recognized multifunctional gasotransmitters and tis actions have been studied in different physiological and pathological contexts, but little is known about its potential role on calcification. Interestingly, we found that H2S promotes calcification under physiological conditions and has an inhibitory effect on pathological processes. This makes H2S a potential therapy for diseases related to pathological calcification.Linked ArticlesThis article is part of a themed section on Hydrogen Sulfide in Biology & Medicine. To view the other articles in this section visithttp://onlinelibrary.wiley.com/doi/10.1111/bph.v177.4/issuetoc
Novel TRRAP mutation causes autosomal dominant non‐syndromic hearing loss
Authors: Xia Wenjun , Hu Jiongjiong , Ma Jing , Huang Jianbo , Wang Xu , Jiang Nan , Zhang Jin , Ma Zhaoxin , Ma Duan 
Published: June 2019

AbstractHereditary non‐syndromic hearing loss is the most common inherited sensory defect in humans. More than 40 genes have been identified as causative genes for autosomal dominant non‐syndromic hearing loss (ADNSHL), but there are many other candidate genes that remain to be discovered. We aimed to identify the causative gene mutation for post‐lingual progressive ADNSHL in a Chinese family. Whole‐exome sequencing, bioinformatic analysis, and Sanger sequencing were used to verify the co‐segregation of a novel pathogenic variant (NM_ 001244580, c.511C>T, p.Arg171Cys) in the TRansformation/tRanscription domain‐Associated Protein gene associated with hearing loss in a three‐generation Chinese family with ADNSHL). Additionally, three more novel variants of transformation/transcription domain associated protein (TRRAP) were detected in 66 sporadic cases of hearing loss. Morpholino oligonucleotides knockdown and clustered regularly interspaced short palindromic repeats/Cas9 knockout zebrafish were constructed to validate the genetic findings. Knockdown or knockout of TRRAP resulted in significant defects in the inner ear of zebrafish, indicating that TRRAP plays an important role in inner ear development. In conclusion, TRRAP (NM_ 001244580, c.511C>T, p.Arg171Cys) co‐segregated with hearing loss in a Chinese family with ADNSHL, and TRRAP deficiency caused hearing disability in zebrafish, suggesting TRRAP is a gene associated with ADNSHL.
Delayed hypersensitivity to palladium dichloride: 15‐year retrospective study in a skin allergy unit
Authors: González‐Ruiz Lucía , Vergara De Caso Eduardo , Peña‐Sánchez Roberto , Silvestre‐Salvador Juan F. 
Published: June 2019

AbstractBackgroundMetal allergies are the most frequent causes of allergic contact dermatitis. Although the use of palladium is increasing, it is not included in any baseline series.ObjectiveTo assess the prevalence of hypersensitivity to palladium and to describe the clinical and demographic characteristics of patients who are sensitized to palladium dichloride (PdCl2).MethodsA single‐centre, retrospective study of 15 years of patch testing with the Spanish baseline series supplemented with PdCl22% pet. was performed. We collected clinical and demographic data and data on co‐sensitization among the metals studied, and we compared patients who were sensitized to palladium, with or without co‐sensitization to nickel, with the rest of the study population.ResultsAmong the 3678 included patients, 730 (19.9%) were sensitized to nickel sulfate. The prevalence of sensitization to PdCl2(n= 316, 8.6%) was higher than the prevalence of sensitization to potassium dichromate (n = 240, 6.5%) and similar to the prevalence of sensitization to cobalt chloride (n = 353, 9.6%). Only 26 (8.2%) of the patients sensitized to palladium were not co‐sensitized to nickel. The percentage of men and patients aged ≥40 years was higher in this subgroup than in the patients with nickel co‐sensitization.ConclusionsGiven the high prevalence of hypersensitivity to PdCl2, this metal salt should be included in the Spanish baseline series, notwithstanding the frequency of co‐sensitization to nickel.
An automated approach for the recognition of intended messages in grouped bar charts
Authors: Burns Richard , Carberry Sandra , Elzer Schwartz Stephanie 
Published: June 2019

AbstractInformation graphics (bar charts, line graphs, grouped bar charts, etc) often appear in popular media such as newspapers and magazines. In most cases, the information graphic is intended to convey a high‐level message. This message plays a role in facilitating the discourse purpose of the document but is seldom repeated in the document's text, headlines, or captions. We present a methodology and an implemented system for recognizing the intended message of a grouped bar chart. The recognition system relies on the following components: (1) a linguistic classifier that processes text in the graphic and predicts the most linguistically salient entity from those that are mentioned in text, (2) a cognitive model that estimates the relative perceptual effort required for an individual to recognize some high‐level message in a graph, and (3) a Bayesian network that captures the probabilistic relationship between the high‐level intended message of a graphic and its communicative signals. This research contributes to three applications: accessibility of information graphics for sight‐impaired individuals, retrieval of information graphics from a digital library, and summarization of multimodal documents.
BRCA1‐associated protein (BAP1)‐inactivated melanocytic tumors
Authors: Zhang Arianna J. , Rush Patrick S. , Tsao Hensin , Duncan Lyn M. 
Published: June 2019

AbstractAlthough discussed using variable terminology, cutaneous BRCA1‐associated protein (BAP1)‐inactivated melanocytic tumor (BIMT) has been considered a discrete diagnostic entity since 2011. Here, we review the initial genomic studies that identified these distinct melanocytic tumors and the clinical and histopathological features that define these tumors. These epithelioid, predominantly dermal, and melanocytic tumors present as erythematous nodules and histopathologically have features that may overlap with Spitz nevi and nevoid melanoma. There is no sex predilection, and cutaneous BIMTs can appear at any age; however, in most familial (germline mutant) cases patients have multiple cutaneous tumors with a first diagnosis in the second or third decade of life; ocular melanoma and other tumors are increasingly identified in these kindreds with germline BAP1 mutation. These tumors have been described with a myriad of terms including: Wiesner nevus, nevoid melanoma‐like melanocytic proliferation (NEMMP), BAP1 mutant Spitz nevus, BAP1 mutant nevoid melanoma, cutaneous BAPoma, and most recently cutaneous BIMT.
Estimated glomerular filtration rate and risk of poor outcomes after stroke
Authors: Vart P. , Barlas R. S. , Bettencourt‐Silva J. H. , Metcalf A. K. , Bowles K. M. , Potter J. F. , Myint P. K. 
Published: June 2019

Background and purposeThe relationship of the estimated glomerular filtration rate (eGFR) with complications after stroke has not been fully characterized for the entire clinical spectrum of eGFR and for the fluctuation in eGFR during hospital stay.MethodsData from the Norfolk and Norwich Stroke Registry recorded between January 2003 and April 2015 were analysed. eGFR was categorized into six clinically relevant categories as per the Kidney Disease Improving Global Outcomes guidelines. The change in eGFR during acute admission was categorized into the following: within 5% change (reference), 5%–20% decline, >20% decline, 5%–20% increase and >20% increase. All‐cause mortality, recurrent stroke, incident myocardial infarction, prolonged hospital stay and stroke disability at discharge were outcomes of interest.ResultsIn all, 10 329 stroke patients (mean age 77.8 years) were followed for a mean of 2.9 years (30 126 person‐years). Multivariable adjusted hazard ratios (95% confidence interval) for all‐cause mortality were 0.91 (0.80–1.04), 0.96 (0.83–1.11), 1.23 (1.06–1.43), 1.54 (1.31–1.82) and 2.38 (1.91–2.97) for eGFR levels 60–89, 45–59, 30–44, 15–29 and <15 respectively, compared to eGFR ≥ 90 ml/min/1.73 m2. The hazard ratios (95% confidence interval) for eGFR change were 1.56 (1.36–1.79), 1.17 (1.05–1.30), 1.47 (1.32–1.62) and 1.71 (1.55–1.88) for >20% decline, 5%–20% decline, 5%–20% increase and >20% increase, respectively, compared to change within 5%. Results were similar for other outcomes except recurrent stroke.ConclusionsStroke patients with eGFR < 45 ml/min/1.73 m2 at hospital admission and >5% decline or increase in eGFR during hospital stay were at substantially higher risk of poor outcomes, particularly all‐cause mortality, myocardial infarction, prolonged hospital stay and disability at discharge.
Nationwide survey on cerebral amyloid angiopathy in Japan
Authors: Sakai K. , Ueda M. , Fukushima W. , Tamaoka A. , Shoji M. , Ando Y. , Yamada M. 
Published: June 2019

Background and purposeA nationwide survey was conducted to understand the epidemiology of cerebral amyloid angiopathy‐related intracerebral hemorrhage (CAA‐related ICH) and cerebral amyloid angiopathy‐related inflammation/vasculitis (CAA‐ri) in Japan.MethodsTo estimate the total number and clinical features of patients with CAA‐related ICH and CAA‐ri between January 2012 and December 2014 and to analyze their clinical features, questionnaires were sent to randomly selected hospitals in Japan.ResultsIn the first survey, 2348 of 4657 departments responded to the questionnaire (response rate 50.4%). The total numbers of reported patients with CAA‐related ICH and CAA‐ri were 1338 and 61, respectively, and their total numbers in Japan were estimated to be 5900 [95% confidence interval (CI) 4800–7100] and 170 (95% CI 110–220), respectively. The crude prevalence rates were 4.64 and 0.13 per 100 000 population, respectively. The clinical information of 474 patients with CAA‐related ICH obtained in the second survey was as follows: (i) the average age of onset was 78.4 years; (ii) the prevalence increased with age; (iii) the disease was common in women; and (iv) hematoma most frequently occurred in the frontal lobe. Sixteen patients with CAA‐ri for whom data were collected in the second survey had the following characteristics: (i) median age of onset was 75 years; (ii) cognitive impairment and headache were the most frequent initial manifestations; and (iii) focal neurological signs, such as motor paresis and visual disturbance, were frequently observed during the clinical course.ConclusionsThe numbers of patients with CAA‐related ICH and CAA‐ri in Japan were estimated.
A robust hybrid artificial neural network double frontier data envelopment analysis approach for assessing sustainability of power plants under uncertainty
Authors: Yousefi Saeed , Soltani Roya , Bonyadi Naeini Ali , Farzipoor Saen Reza 
Published: June 2019

AbstractTo assess sustainability of power plants, this paper presents a novel hybrid method. To this end, self‐organizing map method of artificial neural networks is employed. Then, a double frontier data envelopment analysis is developed to rank power plants in each cluster of decision‐making units. Because outputs of power plants might be uncertain, a robust optimization approach is incorporated into proposed double frontier data envelopment analysis model to present ranks that are robust against different uncertainties. A case study is given to validate the proposed model. The case study shows that the proposed model can present improvement solutions that guide power plants towards efficient frontier and far from inefficient frontier. Given the results, decision makers can decide on which power plants should be closed and which power plants should be expanded.
On the interaction of normal and shear stresses in multiaxial fatigue damage
Authors: Sharifimehr Shahriar , Fatemi Ali 
Published: June 2019

AbstractOne of the important issues in assessing multiaxial fatigue damage is interactions between different components of stress such as normal and shear stresses. The present study investigated this interaction effect on the fatigue behavior of materials with shear failure mode when subjected to multiaxial loading conditions. A method is introduced to model this interaction based on the idea that two types of influence are caused by the normal stress acting on the critical plane orientation. These two types of influence are affecting roughness induced closure, as well as fluctuating normal stress which affects the growth of small cracks in mode II. Shear‐based critical plane damage models which use normal stress as a secondary input, such as FS damage model, could then use the summation of these terms. In order to investigate the effect of the method, constant amplitude load paths with different levels of interaction between the normal and shear stresses, as well as variable amplitude tests with histories both taken from service loading conditions and generated using random numbers were designed for an experimental program. The proposed method was observed to result in improved fatigue life estimations where significant interactions between normal and shear stresses exist.
Accounting for crack tip cyclic plasticity and creep reversal in estimating (Ct)avg during creep‐fatigue crack growth
Authors: Saxena Ashok , Narasimhachary Santosh B. 
Published: June 2019

AbstractCreep‐fatigue crack growth (C‐FCG) rates in a P91 steel at 625°C were correlated as the average time rate of crack growth during hold time, (da/dt)avg, with (Ct)avg. At 60‐second hold time, the rates were lower than for 600‐second hold time. At 600‐second hold time, the crack growth rates converged on to the creep crack growth rate (CCGR) trend. Thus, the CCGR trend represents the upper bound for time‐dependent crack growth rates in P91 materials. The analytical expressions based on considering just the elastic and secondary creep deformation rates overestimated the magnitudes of (Ct)avg by as much as a factor of 10 for the 600‐second hold time tests. After accounting for the effects of cyclic plasticity during unloading, and accounting for only partial reversal of creep strains accumulated during hold time, the estimates of (Ct)avg compared well with the measured values. CR represents the extent of crack tip creep strain reversal, and tpl is the time required for the crack tip creep zone during the hold time to become equivalent in size to the cyclic plastic zone in terms of stress carried by that region. Together, these parameters accurately account for the effects of crack tip cyclic plasticity on the magnitude of (Ct)avg.Both tpl and CR depend on material properties, and the latter also depends on the hold time. A parameter ϕ is introduced that is dependent only on material properties and from which CR can be estimated for a given hold time. tpl and ϕ can be reported as part of the test results from C‐FCG testing.
Effects of processing on the phenolic contents, antioxidant activity and volatile profile of wheat bran tea
Authors: Wang Haoxin , Sun Hongyi , Zhang Pangzhen , Fang Zhongxiang 
Published: June 2019

SummaryWheat bran is a major milling by‐product with significant nutritional importance. This study investigated the influence of processing on the antioxidant activity and volatile profile of wheat bran tea. The processing protocol involved two different pretreatments: soaking and cellulase treatment, followed by steaming and roasting. The results indicated that total phenolic content and antioxidant activity were reduced post both pretreatments, but increased after steaming, and dramatically increased after roasting. The cellulase‐roasted samples had significantly higher antioxidant activity compared to soak‐roasted samples. A total of forty key volatile compounds were identified in the wheat bran tea. The total volatile compounds were significantly increased by both soaking and cellulase treatments and steaming, but reduced by roasting. Compared to soaking pretreatment, cellulase pretreated samples had significantly higher total volatile compounds at each processing step. This study offers a practical method in processing of wheat bran into novel grain tea products.
Burnout and perceived social support: The mediating role of secondary traumatization in nurses vs. physicians
Authors: Hamama Liat , Hamama‐Raz Yaira , Stokar Yaffa N. , Pat‐Horenczyk Ruth , Brom Danny , Bron‐Harlev Efrat 
Published: June 2019

AbstractAimsThe study aimed to examine differences between paediatric nurses and physicians regarding burnout syndrome, secondary traumatic stress (STS) and perceived social support (PSS).BackgroundPaediatric nurses and physicians encounter cumulative effects of treating sick and injured children and helping their families, in situations that might promote burnout and STS.DesignCross‐sectional design.MethodNurses (n = 158) and physicians (N = 76) completed self‐report questionnaires on STS, PSS and burnout.ResultsNurses and physicians had similar rates of STS and burnout but showed significant differences in PSS. Furthermore, STS mediated the association between PSS and burnout for both groups; however, the effect was stronger for nurses in comparison to physicians.ConclusionPaediatric nurses and physicians would benefit from participating in interventions geared towards reducing STS, thus minimizing burnout. Moreover, advocating social support within the organization is needed to bolster the ability for coping with sources of stress.Impact statementNurses' and physicians' involvement in the physical, physiological and mental needs of their paediatric patients might lead to burnout and secondary traumatic stress (STS). However, research on social support in the context of burnout and STS among nurses and physicians is scant. Secondary traumatic stress and burnout were similar for nurses and physicians, though perceived social support (PSS) was higher for nurses. Secondary traumatic stress plays a mediating role in the association between PSS and burnout among nurses and physicians. However, the mediation effect was stronger for nurses. Policy makers would be wise to advocate institutional stress management interventions to reduce secondary traumatic and to reinforce organizational support for nurses and physicians.
Left ventricular sensing in cardiac resynchronization devices—opportunities and pitfalls for device programming
Authors: Haeberlin Andreas , Ploux Sylvain , Noel Antoine , Chauvel Rémi , Welte Nicolas , Marchand Hugo , Haissaguerre Michel , Ritter Philippe , Bordachar Pierre 
Published: June 2019

AbstractIntroductionSome cardiac resynchronization therapy (CRT) device manufacturers (Biotronik, Germany; Boston Scientific, United States) have implemented left ventricular (LV) sensing functionality to prevent pacing into the vulnerable phase. Physicians are only partially aware of programming pitfalls related to LV sensing and general programming advice is lacking.Methods and ResultsWe provide an illustrative case–series‐based review of the variety of potential problems with LV sensing. LV sensing may inappropriately impair CRT delivery due to LV‐sensing issues or improper device programming. This can cause beat‐wise loss of resynchronization but also ongoing desynchronization. On the other hand, LV sensing provides additional diagnostic information, which may reveal intermittent problems of the LV lead such as capture loss.We summarize the available evidence to provide manufacturer‐specific recommendations on device programming and troubleshooting for daily clinical practice.ConclusionCRT devices with LV sensing may suffer from impaired resynchronization due to programming pitfalls. If LV sensing is active (nominal setting in Biotronik and Boston Scientific devices), careful lookout for related problems and resynchronization percentage is required. Optimization is mandatory and even deactivation of LV sensing may have to be considered.