bluuebunny/crossref_metadata_2025_split huggingface dataset:
FOCUS GROUP DISCUSSION MENGENAI PEMAHAMAN PERUBAHAN ATURAN HUKUM INDIKASI GEOGRAFIS BAGI MASYARAKAT PELESTARI PADI PANDANWANGI CIANJUR (MP3C) SEBAGAI PEMEGANG HAK INDIKASI GEOGRAFIS TERDAFTAR
Authors: Aridhayandi M. Rendi 
Published: May 2019

ABSTRAKEra perdagangan global, sejalan dengan konvensi internasional yang telah diratifikasi Indonesia, peranan Merek dan Indikasi Geografis menjadi sangat penting terutama dalam menjaga persaingan usaha yang sehat, berkeadilan, pelindungan konsumen, serta pelindungan Usaha Mikro, Kecil, dan Menengah dan industri dalam negeri. Undang-Undang Nomor 15 Tahun 2001 tentang Merek masih terdapat kekurangan dan belum dapat menampung perkembangan kebutuhan masyarakat di bidang Merek dan Indikasi Geografis serta belum cukup menjamin pelindungan potensi ekonomi lokal dan nasional sehingga perlu diganti. Maka hadir Undang-Undang Nomor 20 Tahun 2016 tentang Merek dan Indikasi Geografis yang lebih konfrehensif pengaturannya. Upaya Pemerintah Daerah Kabupaten Cianjur melalui Masyarakat Pelestari Padi Pandanwangi Cianjur (MP3C) Di tahun 2015 Beras Pandanwangi Cianjur telah terdaftar Indikasi Geografis (IG) tanggal 16 Oktober 2015 dengan nomor permohonan: IG. 00.2014.000011 dan nomor pendaftaran ID G 000000034. Dengan demikian, dianggap perlu untuk melakukan focus group discution ke (MP3C) sebagai pemegang hak Indikasi Geografis Terdaftar. ABSTRACTThe era of global trade, in line with the international conventions that have been ratified by Indonesia, the role of the brand and the geographical indication becomes very important especially in maintaining a healthy business competition, fairness, shield cover consumers, as well as shield cover micro, small, and medium enterprises and industries in the country. Act No. 15 of 2001 Year Brand still contained flaws and yet accommodates the development needs of the community in the field of Geographical Indications as well as brand and not enough guarantee shield cover local and national economic potential so as to need to be replaced. Then the present Act No. 20 Year 2016 about brands and Geographic Indications konfrehensif setting. The efforts of local governments through communities Cianjur Of Cianjur Pandanwangi Rice (MP3C) in year 2015 Pandanwangi Rice Cianjur registered geographical indications (IG) October 16, 2015 with a plea: IG. 00.2014.000011 and registration number ID G 000000034. Thus, it was considered necessary to conduct a focus group to discution (MP3C) as the holder of the rights of a registered geographical indication.
CONCEPTUAL DEVELOPMENT OF THE EARTH TUBE COOLING SYSTEM FOR A TALL BUILDING
Authors: Liu Xiangfeng , Xu Miao , Guo Juanli , Zhu Renjie 
Published: May 2019

ABSTRACT
Earth tubes are earth-to-air heat exchangers that are frequently utilized in energy conscious low-rise buildings, but are scarcely reported for tall buildings. The feasibility of applying earth tube cooling to tall buildings in a hot summer and cold winter climate zone was studied in this paper. Firstly, the designed cooling load of a tall building was obtained from the energy simulation using the baseline and the modified models with applicable energy efficiency measures. Based on the load, the required cooling capacity, the overall section area and the effective length of the earth tube system was deduced from the heat transfer and fluid flow calculation analytically. Then the performance of the earth tube system was crosschecked and verified via the Computational Fluid Dynamics (CFD) simulation. In the CFD simulation, earth tubes with different diameters and lengths, as well as a full-scale earth tube model with surrounding soil above the depth of constant temperature, were investigated. The outlet air temperatures of the full-scale models were computed with the consideration of different axial distances between adjacent tubes. Meanwhile, multiple conceptual design schemes and the tunnel construction method for the earth tube system were proposed from the perspective of performance enhancement, constructability, efficiency and economy. It revealed that earth tube systems are conditionally feasible for some tall buildings if their design guidelines for climate, underground spaces, construction method, friction of tube interior surface, optimization of effective length and axial distance, as well as synergy with other energy efficiency measures are followed. Even the cooling capacity of earth tubes degrade with time due to the accumulated heat underground, but in a hot summer and cold winter climate zone it can still possibly produce cooled air for a tall building with a Floor Area Ratio of less than 7 effectively in summer.
PERFORMANCE INDICATORS FOR ENERGY EFFICIENCY RETROFITTING IN MULTIFAMILY RESIDENTIAL BUILDINGS
Authors: Basu Chaitali , Paul Virendra Kumar , Syal M.G. Matt 
Published: May 2019

ABSTRACT
The energy performance of an existing building is the amount of energy consumed to meet various needs associated with the standardized use of a building and is reflected in one or more indicators known as Building Energy Performance Indicators (EnPIs). These indicators are distributed amongst six main factors influencing energy consumption: climate, building envelope, building services and energy systems, building operation and maintenance, occupants' activities and behaviour, and indoor environmental quality. Any improvement made to either the existing structure or the physical and operational upgrade of a building system that enhances energy performance is considered an energy efficiency retrofit. The main goal of this research is to support the implementation of multifamily residential building energy retrofits through expert knowledge consensus on EnPIs for energy efficiency retrofit planning. The research methodology consists of a comprehensive literature review which has identified 35 EnPIs for assessing performance of existing residential buildings, followed by a ranking questionnaire survey of experts in the built-environment to arrive at a priority listing of indicators based on mean rank. This was followed by concordance analysis and measure of standard deviation. A total of 280 experts were contacted globally for the survey, and 106 completed responses were received resulting in a 37.85% response rate. The respondents were divided into two groups for analysis: academician/researchers and industry practitioners. The primary outcome of the research is a priority listing of EnPIs based on the quantitative data from the knowledge-base of experts from these two groups. It is the outcome of their perceptions of retrofitting factors and corresponding indicators. A retrofit strategy consists of five phases for retrofitting planning in which the second phase comprises an energy audit and performance assessment and diagnostics. This research substantiates the performance assessment process through the identification of EnPIs.
A Precision B Cell–Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation
Authors: Franks S. Elizabeth , Getahun Andrew , Cambier John C. 
Published: May 2019

Abstract
The inositol lipid phosphatases PTEN and SHIP-1 play a crucial role in maintaining B cell anergy and are reduced in expression in B cells from systemic lupus erythematosus and type 1 diabetes patients, consequent to aberrant regulation by miRNA-7 and 155. With an eye toward eventual use in precision medicine therapeutic approaches in autoimmunity, we explored the ability of p110δ inhibition to compensate for PI3K pathway dysregulation in mouse models of autoimmunity. Low dosages of the p110δ inhibitor idelalisib, which spare the ability to mount an immune response to exogenous immunogens, are able to block the development of autoimmunity driven by compromised PI3K pathway regulation resultant from acutely induced B cell–targeted haploinsufficiency of PTEN and SHIP-1. These conditions do not block autoimmunity driven by B cell loss of the regulatory tyrosine phosphatase SHP-1. Finally, we show that B cells in NOD mice express reduced PTEN, and low-dosage p110δ inhibitor therapy blocks disease progression in this model of type 1 diabetes. These studies may aid in the development of precision treatments that act by enforcing PI3K pathway regulation in patients carrying specific risk alleles.
Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding
Authors: Qu Zehui , Li Zibin , Ma Lizhen , Wei Xiaohui , Zhang Lijie , Liang Ruiying , Meng Geng , Zhang Nianzhi , Xia Chun 
Published: May 2019

Abstract
Bats are natural reservoir hosts, harboring more than 100 viruses, some of which are lethal to humans. The asymptomatic coexistence with viruses is thought to be connected to the unique immune system of bats. MHC class I (MHC I) presentation is closely related to cytotoxic lymphocyte immunity, which plays an important role in viral resistance. To investigate the characteristics of MHC I presentation in bats, the crystal structures of peptide–MHC I complexes of Pteropus alecto, Ptal-N*01:01/HEV-1 (DFANTFLP) and Ptal-N*01:01/HEV-2 (DYINTNLVP), and two related mutants, Ptal-N*01:01/HEV-1PΩL (DFANTFLL) and Ptal-N*01:01ΔMDL/HEV-1, were determined. Through structural analysis, we found that Ptal-N*01:01 had a multi-Ala–assembled pocket B and a flexible hydrophobic pocket F, which could accommodate variable anchor residues and allow Ptal-N*01:01 to bind numerous peptides. Three sequential amino acids, Met, Asp, and Leu, absent from the α1 domain of the H chain in other mammals, were present in this domain in the bat. Upon deleting these amino acids and determining the structure in p/Ptal-N*01:01ΔMDL/HEV-1, we found they helped form an extra salt-bridge chain between the H chain and the N-terminal aspartic acid of the peptide. By introducing an MHC I random peptide library for de novo liquid chromatography–tandem mass spectrometry analysis, we found that this insertion module, present in all types of bats, can promote MHC I presentation of peptides with high affinity during the peptide exchange process. This study will help us better understand how bat MHC I presents high-affinity peptides from an extensive binding peptidome and provides a foundation to understand the cellular immunity of bats.
Bilateral Strength Asymmetries and Unilateral Strength Imbalance: Predicting Ankle Injury When Considered With Higher Body Mass in US Special Forcesa
Authors: Eagle Shawn R. , Kessels Marijn , Johnson Caleb D. , Nijst Branco , Lovalekar Mita , Krajewski Kellen , Flanagan Shawn D. , Nindl Bradley C. , Connaboy Chris 
Published: May 2019

ContextAnkle injury is one of the most common conditions in athletics and military activities. Strength asymmetry (SA) and imbalance may represent a risk factor for injury, but past investigations have produced ambiguous conclusions. Perhaps one explanation for this ambiguity is the fact that these authors used univariate models to predict injury.ObjectiveTo evaluate the predictive utility of SA and imbalance calculations for ankle injury in univariate and multivariate prediction models.DesignProspective cohort study.SettingLaboratory.Patients or Other ParticipantsA total of 140 male US Air Force Special Forces.Main Outcome Measure(s)Baseline testing consisted of body composition, isometric strength, and aerobic and anaerobic capacity. A clinician conducted medical chart reviews 365 days posttesting to document the incidence of ankle injury. Strength asymmetries were calculated based on the equations most prevalent in the literature along with known physiological predictors of injury in the military: age, height, weight, body composition, and aerobic capacity. Simple logistic regression was conducted using each predictor, and backward stepwise logistic regression was conducted with each equation method and the physiological predictors entered initially into the model.ResultsStrength asymmetry or imbalance or both, as a univariate predictor, was not able to predict ankle injury 365 days posttesting. Body mass (P = .01) and body mass index (P = .01) significantly predicted ankle injury. Strength asymmetry or imbalance or both significantly predicted ankle injury when considered with body mass (P = .002–.008).ConclusionsAs a univariate predictor, SA did not predict ankle injury. However, SA contributed significantly to predicting ankle injury in a multivariate model using body mass. Interpreting SA and imbalance in the presence of other physiological variables can help elucidate the risk of ankle injury.
Communicate as a Professional
Authors: Jansen Carel , Stadler Leon , Douma Aline , Steehouder Michaël ,   Noordhoff
Published: May 2019

Across a wide range of programs in international higher education, students prepare themselves for a career in their professional field. Learning how to communicate as a professional is an essential part of that preparation. In order to carry out their communication tasks, professionals must possess a large repertoire of knowledge and skills. They also must be able to decide what best suits the situation and the goals they want to achieve. Already during their training, students come across a variety of communication tasks that are largely new to them. For these tasks, too, they need a broad knowledge and skills repertoire from which they can make the right choices.
'Communicate as a Professional' offers a solid foundation for students to develop the communication knowledge and skills they need, both when working as a professional after they have graduated and when following an educational program that prepares them for this future.
Remembrance: A Husserlian Phenomenology of Sufi Practice
Authors: Applebaum Marc 
Published: May 2019

ABSTRACTThe study seeks to answer the phenomenological question: What in essence is religious experience—specifically, the lived experience of “remembrance” (dhikr) in Sufi practice within the schools of Sufism shaped by the “Greatest Master,” Ibn al-'Arabi? The eidetic structure of remembrance is the awakening of the individuated human subject to recollecting the primordial ground of his or her identity as a dynamic instantiation of the Absolute. This is simultaneously experienced as the subject becoming the object of remembrance—that is, being remembered by the Absolute. This transforms the psychological ego's relationship to its own embodied, affective, and cognitive living, as the “center of gravity” of that ego shifts from an egocentric one—that is, an identification with the natural attitude standpoint of the personal ego—to progressively greater centeredness in the transcendental ego as a locus of ongoing world constitution and primordial self-presence, while nevertheless living as a unique individual.
Teologia, Ética e Sociedade: reflexões sobre o bem-viver a partir da antropologia filosófica de Paul Ricoeur
Authors: Nobre José Aguiar 
Published: May 2019

A contemporaneidade é uma época propícia para se discutir a distinção entre o justo e obom. Entende-se que essa distinção está diretamente vinculada às relações intrínsecas do Estado secular, muitas vezes indiferente ao cuidado com a justiça social, cujasconsequências ceifam vidas, ora de forma velada, ora desveladamente, contrariandoassim a teologia da criação. Esta é inteiramente soteriológica e não poderá jamais secontentar com o estado de deterioração humana. É da natureza das sociedades democráticas relacionar várias concepções atreladas à ética do bem viver, circunscritasao bom e ao bem, dentro de uma mesma sociedade. Essa relação muitas vezes emintersecção invisível está ligada à necessidade cristã de reivindicar uma situação justapara todos. Defende-se que cada um deverá perseguir o seu próprio bem, o seu próprio sentido de bem, cultivando o entendimento de que a condição para isso é o bem dacoletividade. Naturalmente, as comunidades diferentes têm concepções divergentes de bem e de bom, no entanto, precisam conviver numa mesma sociedade e aí reside a problemática: como atingir o bem-viver garantindo a justiça para todos? Indaga-se: oque é afinal o “bem-viver”, segundo o pensamento de Paul Ricoeur? Atrelada à estaindagação vem a pergunta pelos seus caminhos, a saber: quais os caminhos para a genuína efetivação do bem-viver? Hipoteticamente entende-se que o bem viver se atingequando o ser humano está bem consigo mesmo, com os outros e atuando, civilizadamente, nas instituições justas em prol da vida digna em comunidade.
Evaluation of niche adaptation features by genome data mining approach of Escherichia coli urinary and gastrointestinal strains
Authors: Paim Thiago GS , Sambrano Gustavo E , Reiter Keli C , Sant'Anna Fernando H , Soares Renata , Mott Mariana , Cibulski Samuel P , d'Azevedo Pedro A 
Published: May 2019

Background. Urinary Tract Infections (UTIs) are among most common infections in humans. The vast majority are caused by Escherichia coli, occasionally responsible for severe clinical manifestations. Although the species frequently adheres and colonizes the bladder mucosa, its reservoir is the host gastrointestinal tract. Therefore, the study was designed to evaluate genomic features for niche adaptation of urinary and gastrointestinal strains of E. coli by data mining approach.
Results. In the E. coli strains, the repertoire of genes was higher than those found in previous studies, and the majority of genes associated to primary metabolism did not depend of bacteria niche, with exception of cell cycle-division, cell motility and secondary metabolite metabolism. Urinary tract isolates of E. coli had great density of virulence and resistance genes carried by prophages.
Conclusion. The urinary and gastrointestinal strains of E. coli evaluated in the study presented an open pan-genome, with groups of functional annotation genes associated to specific niches. In addition, gastrointestinal isolates of E. coli were demonstrated as important reservoir of resistance genes.
AN INSIGHT INTO MATERNAL DEATH CAUSED BY POSTPARTUM HEMORRHAGE IN WESTERN TIMOR, INDONESIA
Authors: Tauho Kristiani Desimina , Karwur Ferry Fredy 
Published: May 2019

Maternal deaths in Timor Island, East Nusa Tenggara Province, are one of the contributors to the overall maternal mortality rate (MMR) of Indonesia. The MMR of Western Timor Island was 150/100,000 live births in 2015. The aim of this qualitative study was to explore the perceived causes of maternal death due to postpartum hemorrhage. Data were obtained from family members, traditional birth attendants, and Posyandu cadres, as well as health providers. Using the retrospective method, this study traced six out of nine postpartum hemorrhage cases in the four sub-districts with the highest maternal death rate in 2010. The research findings showed that most childbirth processes were done at home without any help from health workers. Postpartum hemorrhage happened among women ranging from 24-42 years old; five among them had been pregnant more than four times. Medically, five cases were caused by a prolonged third stage of labor due to a retained placenta. Non-medical factors causing postpartum hemorrhage were poor accessibility, lack of communication devices, and lack of infrastructure. Keywords: maternal death, postpartum hemorrhage, Western Timor Abstrak Pengetahuan Tentang Kematian Maternal Karena Perdarahan Postpartum di Timor Barat, Indonesia. Kematian maternal di Pulau Timor, Provinsi Nusa Tenggara Timur, merupakan salah satu penyumbang Angka Kematian Ibu (AKI) di Indonesia. Tahun 2015, AKI di Pulau Timor bagian barat adalah sebesar 150/100.000 kelahiran hidup. Tujuan dari studi kualitatif ini adalah untuk mengeksplorasi persepsi para pihak yang paling mengetahui mengenai penyebab kematian maternal karena perdarahan postpartum. Data diberikan oleh anggota keluarga, dukun bersalin, dan kader Posyandu, serta penyedia layanan. Menggunakan metode retrospektif, penelitian ini menyusur enam dari sembilan kasus perdarahan postpartum yang terjadi di empat kecamatan yang memiliki angka kematian maternal tertinggi pada tahun 2010. Hasil penelitian menunjukkan bahwa sebagian besar prosedur persalinan dilakukan di rumah tanpa bantuan dari tenaga kesehatan. Perdarahan postpartum terjadi di antara wanita dengan rentang umur 24–42 tahun; empat di antara mereka sudah pernah hamil sebanyak lebih dari empat kali. Secara medis, lima kasus disebabkan oleh perpanjangan kala tiga persalinan berhubungan dengan retensi plasenta. Faktor- faktor non medis yang menyebabkan perdarahan posrpartum adalah aksesibilitas yang buruk, ketiadaan piranti komunikasi, dan kurangnya infrastruktur. Kata kunci: kematian ibu, perdarahan postpartum, Timor Barat
Pattern of Drug Abuse among Adolescents in Lokoja Metropolis of Kogi State, Nigeria
Authors: Otorkpa Oche Joseph 
Published: May 2019

Background: Adolescence is characterized by thrill-seeking and looking for new experiences which are often accompanied with experimentation with substance use and testing boundaries with its attendant consequences.
Aim: The aim of this study is to provide an overview of the prevalence levels, pattern and types of abused substances in Lokoja metropolis and provide valuable information for stakeholders.
Study Design: This was a cross-sectional, descriptive study carried out among adolescents In Lokoja Metropolis of Kogi State, Nigeria.
Place and Duration of Study: The study was carried out in Lokoja, Kogi State, Nigeria from June to September 2018.
Methodology: A questionnaire-based study using a simple random sampling method to select respondents.
Results: A total of one hundred and sixty four questionnaires were administered after assent from the respondents and signed consent from parents or guardians. The respondents who were made up of 90 males and 74 females, 44 respondents fell between the age category of 10-13, 38 and 82 respondents fell within the categories of 14-16 and 17- 19 respectively. Of these respondents, 5 were educated to primary school level, 129 to secondary level, 27 of them to tertiary level and 3 of them had no formal education at all. The use of illicit drugs appeared to be increasing with age, for male respondent, 6.9% for ages 10-13, 14.2% for ages 14-16 and 32.5% for ages 17 to 19, among the female respondents same pattern was observed 0%, 11.76% and 11.9 % respectively for the same age categories. Furthermore, the use of illicit drug was more prevalent in males than in females, the prevalence rate for males was 20% and 9.46% in females. Overall, peer pressure was found to have the most influence among adolescents who use illicit substances and marijuana was found to be the most abused drug by adolescents in the metropolis, 46.67% in males, and 32.43% in females. However, the rate of abuse of codeine and non-codeine based cough syrups among females was also found to be higher and almost at par with marijuana 31.08%. Although there was a significant statistical relationship between age and drug abuse in males with a p-value of 0.024151 at p < 0.05, the relationship was not significant among females.
Conclusion: The abuse of marijuana being the most abused drug by adolescents in the metropolis, 46.67% in males, and 32.43% in females in addition to the abuse of new substances especially the high rate of codeine and non-codeine based cough syrups among females is an important finding with far reaching public health consequences. There is the need for increased awareness on the harmful physical, mental and social effects of substance abuse and stricter enforcement of drug laws and regulations to protect adolescents.