bluuebunny/crossref_metadata_2025_split huggingface dataset:
Was ist gesichert in der Therapie der metabolischen Azidose bei chronischer Nierenkrankheit?
Authors: Ritter Alexander , Kuhn Christian , Mohebbi Nilufar 
Published: November 2024

ZusammenfassungEine präzise Regulation des Säure-Basen-Haushalts ist für viele Organe und physiologische Prozesse essenziell. Säureretention und metabolische Azidose (MA) sind häufige Komplikationen bei chronischer Nierenkrankheit („chronic kidney disease“ [CKD]) und treten auch nach Nierentransplantation auf. Neben diätetischen Maßnahmen kommen medikamentöse Therapien zur Azidosekorrektur zum Einsatz, mit Natrium(hydrogen)karbonat als am häufigsten eingesetzter Substanz. Mehrere Studien konnten einen positiven Effekt einer Azidosekorrektur auf die CKD-Progression aufzeigen. Die Studienresultate sind jedoch nicht einheitlich und es ist von eher kleineren Behandlungseffekten auszugehen. Nach Nierentransplantation konnte bisher keine positive Wirkung auf die Transplantatfunktion nachgewiesen werden. Die MA ist mit einer eingeschränkten Knochenqualität assoziiert, wobei Alkaliinterventionsstudien bislang einen positiven Effekt auf Marker des Knochenstoffwechsels, nicht jedoch auf die Knochendichte gezeigt haben. Die MA ist mit einer erhöhten kardiovaskulären Ereignisrate assoziiert, Interventionsstudien mit harten kardiovaskulären Endpunkten fehlen jedoch bis dato. Eine Interventionsstudie mit jedoch wesentlichen Limitationen konnte einen positiven Effekt einer Alkalitherapie auf die Mortalität zeigen. Eine Azidosekorrektur scheint sich positiv auf den Protein- und Muskelkatabolismus auszuwirken, wobei eine Verbesserung der körperlichen Leistungsfähigkeit in einer geriatrischen Population nicht gezeigt werden konnte. Bezüglich der endokrinologischen Effekte einer Alkalitherapie existieren nur sehr wenige Studien. Hier zeigten sich ein günstiger Effekt auf den Glukosestoffwechsel und ein möglicher Nutzen in Bezug auf die Schilddrüsenfunktion bei prädialytischen Patienten mit CKD. Aufgrund der insgesamt eher geringen bis moderaten Evidenz für den Nutzen einer Alkalitherapie sowie angesichts der teilweise widersprüchlichen Studienlage wird in den aktualisierten Leitlinien von Kidney Disease: Improving Global Outcomes (KDIGO) die Empfehlung für Erwachsene abgeschwächt und eine Alkalibehandlung vorgeschlagen, um ein Serumbikarbonat < 18 mmol/l (bislang < 22 mmol/l) und die damit verbundenen Komplikationen zu vermeiden.
Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice
Authors: Sayour Nabil V. , Kucsera Dániel , Alhaddad Ayham R. , Tóth Viktória É. , Gergely Tamás G. , Kovács Tamás , Hegedűs Zsombor I. , Jakab Márk E. , Ferdinandy Péter , Varga Zoltán V. 
Published: November 2024

Abstract
Despite accumulating data on underlying mechanisms, the influence of sex and prevalent cardio-metabolic co-morbidities on the manifestation and severity of immune checkpoint inhibitor (ICI)-induced cardiotoxicity has not been well defined. To elucidate whether sex and prevalent cardio-metabolic co-morbidities affect ICI-induced cardiotoxicity, we randomized 17-month-old male and female mice to receive control diet (CON) or high-fat diet (HFD) + L-NAME—a well-established mouse model of cardio-metabolic co-morbidities—for 17 weeks (n = 5–7), and evaluated markers of T-cell function in the spleen. As expected, HFD + L-NAME significantly increased body- and heart weight, and serum cholesterol levels, and caused no systolic dysfunction, however, led to diastolic dysfunction, cardiomyocyte hypertrophy, and increased fibrosis only in males compared to corresponding CON. Western blot analyses of splenic immune checkpoint protein levels showed differential expression depending on sex and prevalent cardio-metabolic co-morbidities, suggesting T-cell exhaustion in both sexes on HFD + L-NAME, but more pronounced in males. In a sub-study with a similar setup, we tested cardiotoxic manifestations of ICI by treating mice with anti-PD-1 monoclonal antibody (ICI) for the last 2 weeks of diet administration (n = 5–7). After 2 weeks of ICI treatment, cardiac systolic functions significantly decreased in CON, but not in HFD + L-NAME groups of both sexes compared to baseline (before ICI administration). In conclusion, in this exploratory study using aged mice, we describe for the first time that ICI-related systolic dysfunction is diminished in both sexes when obesity and hypercholesterolemia are present, possibly due to obesity-related T-cell exhaustion.
SUMOylation of rice DELLA SLR1 modulates transcriptional responses and improves yield under salt stress
Authors: Fernandes Telma , Gonçalves Nuno M. , Matiolli Cleverson C. , Rodrigues Mafalda A. A. , Barros Pedro M. , Oliveira M. Margarida , Abreu Isabel A. 
Published: November 2024

Abstract
Main conclusion
SUMOylation of SLR1 at K2 protects productivity under salt stress, possibly by modulation of SLR1 interactome.

Abstract
DELLA proteins modulate GA signaling and are major regulators of plant plasticity to endure stress. DELLAs are mostly regulated at the post-translational level, and their activity relies on the interaction with upstream regulators and transcription factors (TFs). SUMOylation is a post-translational modification (PTM) capable of changing protein interaction and has been found to influence DELLA activity in Arabidopsis. We determined that SUMOylation of the single rice DELLA, SLENDER RICE1 (SLR1), occurs in a lysine residue different from the one identified in Arabidopsis REPRESSOR OF GA (RGA). Artificially increasing the SUMOylated SLR1 levels attenuated the penalty of salt stress on rice yield. Gene expression analysis revealed that the overexpression of SUMOylated SLR1 can regulate GA biosynthesis, which could partially explain the sustained productivity upon salt stress imposition. Furthermore, SLR1 SUMOylation blocked the interaction with the growth regulator YAB4, which may fine-tune GA20ox2 expression. We also identified novel SLR1 interactors: bZIP23, bHLH089, bHLH094, and OSH1. All those interactions were impaired in the presence of SUMOylated SLR1. Mechanistically, we propose that SUMOylation of SLR1 disrupts its interaction with several transcription factors implicated in GA-dependent growth and ABA-dependent salinity tolerance to modulate downstream gene expression. We found that SLR1 SUMOylation represents a novel mechanism modulating DELLA activity, which attenuates the impact of stress on plant performance.
Starshaped compact hypersurfaces in warped product manifolds I: prescribed curvature equations
Authors: Wang Bin 
Published: November 2024

AbstractWe derive global curvature estimates for closed, strictly star-shaped$$(n-2)$$(n-2)-convex hypersurfaces in warped product manifolds, which satisfy the prescribed$$(n-2)$$(n-2)-curvature equation with a general right-hand side. The proof can be readily adapted to establish curvature estimates for semi-convex solutions to the generalk-curvature equation. Furthermore, it can also be used to prove the same estimates fork-convex solutions to the prescribed curvature measure type equations.
Lifespan estimates for semilinear damped wave equation in a two-dimensional exterior domain
Authors: Ikeda Masahiro , Sobajima Motohiro , Taniguchi Koichi , Wakasugi Yuta 
Published: November 2024

AbstractLifespan estimates for semilinear damped wave equations of the form $$\partial _t^2u-\Delta u+\partial _tu=|u|^p$$

∂
t
2

u
-
Δ
u
+

∂
t

u
=

|
u
|

p

in a two dimensional exterior domain endowed with the Dirichlet boundary condition are dealt with. For the critical case of the semilinear heat equation $$\partial _tv-\Delta v=v^2$$

∂
t

v
-
Δ
v
=

v
2

with the Dirichlet boundary condition and the initial condition $$v(0)=\varepsilon f$$

v
(
0
)
=
ε
f

, the corresponding lifespan can be estimated from below and above by $$\exp (\exp (C\varepsilon ^{-1}))$$

exp
(
exp

(
C

ε

-
1

)

)

with different constants C. This paper clarifies that the same estimates hold even for the critical semilinear damped wave equation in the exterior of the unit ball under the restriction of radial symmetry. To achieve this result, a new technique to control $$L^1$$

L
1

-type norm and a new Gagliardo–Nirenberg type estimate with logarithmic weight are introduced.
The Effect of INSIGHTS on Developmental Trajectories of Children’s Self- Regulation
Authors: Rudasill Kathleen Moritz , Reichenberg Ray E. , Eum Jungwon , Barrett Jentry Stoneman , Wilson Emily , Joo Yuenjung , Sealy Martinique A. 
Published: November 2024

AbstractThe development of self-regulation is critical for children’s positive interactions with others and successful adjustment to school. Using their self-regulation skills, children can adapt their temperamental, emotional, and behavioral reactions to environmental stimuli. Greater self-regulation is advantageous in the classroom, as more regulated children have an easier time with basic behavioral expectations, and are more likely to persist with difficult tasks, work efficiently, and pay attention to instructions. INSIGHTS into Children’s Temperament (INSIGHTS) is a temperament-based intervention that improves kindergarten and first-grade children’s social-emotional development and academic learning. In the current study, we examined the effects of INSIGHTS on rural Midwestern children’s self-regulation development (i.e., attention, inhibitory control), compared to control classrooms. In addition, we explored the effects of children’s baseline self-regulation and the effects of the intervention on children’s developmental trajectories. Students (N = 147) from 61 classrooms were randomly assigned to INSIGHTS or control conditions by school. Children’s self-regulation skills whereas examined at four different times. Multiple regression models were fit, and results suggest that INSIGHTS participants exhibited greater self-regulation at Time 4 as compared to the control group. Additionally, latent growth curve models were used to model linear growth. Results suggest that INSIGHTS participants experienced increased growth rates for attention, inhibitory control, and sustained attention compared to the control group. Our study provides evidence for the positive effects of a social-emotional classroom intervention on the developmental trajectory of children’s self-regulation.
A comparative study of the antiviral effects of biogenic silver nanoparticles and nanosilica (nSiO2) against Leek yellow stripe virus on Allium sativum L
Authors: Abdelkader Hayam S. , Kheder Ahmed A. , Amin Hala A. , Shafie Radwa M. 
Published: November 2024

Abstract
Garlic is a highly valued cash crop worldwide, but its economic value can be diminished by Leek yellow stripe virus (LYSV), which causes symptoms in infected plants and reduces yields. The presence of LYSV was confirmed by host range, DAS-ELISA, RT‒PCR, and DNA sequencing. This study aimed to evaluate the antiviral potential of biogenic silver nanoparticles (Cz-AgNPs) and chemically synthesized metal nanosilica (nSiO2) against LYSV-Eg (OR343513.1) isolates. The morphological structure of the biogenic and metal nanoparticles was evaluated using transmission electron microscopy (TEM), zeta potential, and UV‒visible spectrum analysis. The inhibitory percentages of both nanoparticles were determined daily by monitoring symptom development and weekly by DAS-ELISA in comparison with both negative and positive controls. RT‒PCR was used to verify LYSV inhibition in garlic/nano treated plants at the end of the experiment. The results showed that foliar application of 300 µg/ml Cz-AgNPs and/or 3.0 mg/ml nSiO2 48 h post-virus inoculation inhibited the virus significantly by 90% and 95%, respectively. The combined therapy of both 300 µg/ml Cz-AgNPs and 3.0 mg/ml nSiO2 also resulted in a high inhibitory effect (95%) when applied 48 h post-virus inoculation. However, the inhibitory effects of the combined treatment were not significantly different from the individual treatments at the same concentrations. Furthermore, the application of Cz-AgNPs and nSiO2, whether individually or in combination, did not result in a significant growth-promoting effect in garlic plants compared to the AgNO3 treatment. This study demonstrated that nano therapy has the potential to manage viral infections in garlic plants. This highlights their potential for eco-friendly disease control.
Factors influencing management of dry cell battery waste: a case of Greater Accra Region in Ghana
Authors: Debrah Justice Kofi , Teye Godfred Kwesi , Dinis Maria Alzira Pimenta 
Published: November 2024

AbstractIndiscriminate disposal of dry cell battery (DCB) waste contributes to environmental and public health issues in developing countries such as Ghana, due to the toxic nature of this specific waste. Accordingly, a study was conducted in Accra, Ghana, to determine the socio-economic and demographic factors influencing handling DCB waste, aiming a sustainable environment. Using a random sampling technique, a descriptive cross-sectional survey was conducted, encompassing 367 respondents from the Accra-Tema Metropolitan areas and Tema West Municipal Assembly in Greater Accra, Ghana. Using descriptive and multivariate statistical methods, the survey data were analysed with the Statistical Package for Social Sciences (SPSS) version 27. The results of this study show that female gender and residential area are likely to positively influence the use of DCB at home. Education significantly affects the use of DCB and its proper disposal. The results also suggest that 78% of the respondents disposed of DCB waste in waste bins. The mean monthly income of the respondents stands at USD 270, which is average and likely partially to positively influence the disposal of the DCB. The data collected revealed that female gender, age group, family size, and education level influence the indiscriminate disposal of DCB waste and DCB waste recycling. The results highlight that educated females above the age of 55, with a monthly income, are likely to properly segregate DCB waste. This study contributes to the knowledge gap in relation to dry cell battery waste management (DCBWM) in developing countries, aiming to advance global sustainability. This study is expected to contribute to educate and create awareness in managing DCB waste to reduce its indiscriminate disposal which leads to environmental pollution and negatively affects human health and environmental sustainability in Ghana.
Parenting Under Pressure: Associations between Perceived Social Pressure and Parental Involvement among Mothers and Fathers
Authors: Venard Gaëlle , Zimmermann Grégoire , Antonietti Jean-Philippe , Nunes Cindy Eira , Van Petegem Stijn 
Published: November 2024

AbstractIn many Western countries, the ideology of intensive parenting has gained prominence in the discourse of experts, policymakers, and within popular culture. This ideology emphasizes deep parental involvement in emotional, physical, and financial aspects (Lee et al., 2014). Meeting these demanding standards can exert significant pressure on parents, especially on mothers often considered as the primary caregiver. Moreover, these pressures may prompt parents to be highly, and potentially overly, involved in their children’s lives. Using data from 146 parent dyads (N = 292 parents; Mage = 47.57 years) of Swiss adolescents, the study explores parental perceptions of pressure to be a perfect parent and its association with one positive (responsiveness) and two negative types of involvement (overprotection and overvaluation). Thereby, we estimated Actor-Partner Interdependence Models (APIM) to examine mutual influences between mothers and fathers. The results indicated that mothers reported experiencing significantly more pressure than fathers. We found evidence for a positive association between perceptions of pressure and parental overprotection among both parents. The results also showed that there was a significant association between feelings of pressure and overvaluation, but only among fathers. Associations between pressure and responsiveness were not significant, and no significant partner effects were observed in any of the models. In conclusion, mothers particularly face heightened pressure to be perfect parents, but both parents may adapt their parenting strategies in response to perceived pressure to be perfect as a parent. These findings highlight the potential issues associated with societal pressures on parents and their impact on parenting behavior.
Empirically exploring the space of monostationarity in dual phosphorylation
Authors: Cai May , Himmelmann Matthias , Ostermann Birte 
Published: November 2024

AbstractThe dual phosphorylation network provides an essential component of intracellular signaling, affecting the expression of phenotypes and cell metabolism. For particular choices of kinetic parameters, this system exhibits multistationarity, a property that is relevant in the decision-making of cells. Determining which reaction rate constants correspond to monostationarity and which produce multistationarity is an open problem. The system’s monostationarity is linked to the nonnegativity of a specific polynomial. A previous study by Feliu et al. provides a sufficient condition for monostationarity via a decomposition of this polynomial into nonnegative circuit polynomials. However, this decomposition is not unique. We extend their work by a systematic approach to classifying such decompositions in the dual phosphorylation network. Using this classification, we provide a qualitative comparison of the decompositions into nonnegative circuit polynomials via empirical experiments and improve on previous conditions for the region of monostationarity.
Reliability and Construct Validity of the Work Rehabilitation Questionnaire Domains in Patients with Persistent Low Back Pain
Authors: Hansen Anders , Lauridsen Henrik Hein , Escorpizo Reuben , Søgaard Karen , Søndergaard Jens , Schiøttz-Christensen Berit , Mortensen Ole Steen 
Published: November 2024

Abstract
Purpose
The Work Rehabilitation Questionnaire (WORQ) assesses patient functioning, including psychological, physical, and cognitive limitations. This study evaluates the WORQ domains in individuals with persistent low back pain (LBP), focusing on reliability and construct validity.

Methods
Individuals aged 18–65 with LBP completed WORQ and the workability index single item. A subgroup undertook sit-to-stand and 6-min walking tests and re-evaluated WORQ after 14 days. Reliability was assessed through internal consistency (McDonald’s omega and Cronbach’s alpha), test–retest reliability, and smallest detectable change. Construct validity was analyzed via Spearman’s rank correlation and known group validity, with physical functioning also examined against sit-to-stand and 6-min walk test results for sensitivity/specificity. Floor and ceiling effects were assessed through classical and scale width methods.

Results
Of 425 participants, 149 completed physical tests, and 102 re-assessed WORQ. McDonald’s omega and Cronbach’s alpha indicated high internal consistency (0.92–0.96) with strong test–retest reliability (intraclass-correlation coefficients: 0.74–0.82). The smallest detectable change ranged from 4.62 to 7.82. Predictions from 7 out of 8 hypotheses were confirmed. Notable differences in domain scores were observed based on disability level and sick leave status, with varied diagnostic performance in physical functioning items. Potential floor effects were noted using the scale width method.

Conclusions
The WORQ demonstrated good reliability and satisfactory validity in assessing work-related functioning in individuals with persistent LBP. These findings support its use as a comprehensive tool for evaluating psychological, physical, and cognitive limitations. However, varied diagnostic performance in physical functioning items and potential floor effects suggest cautious interpretation in diverse clinical settings.
Strong Lensing by Galaxies
Authors: Shajib A. J. , Vernardos G. , Collett T. E. , Motta V. , Sluse D. , Williams L. L. R. , Saha P. , Birrer S. , Spiniello C. , Treu T. 
Published: November 2024

AbstractStrong gravitational lensing at the galaxy scale is a valuable tool for various applications in astrophysics and cosmology. Some of the primary uses of galaxy-scale lensing are to study elliptical galaxies’ mass structure and evolution, constrain the stellar initial mass function, and measure cosmological parameters. Since the discovery of the first galaxy-scale lens in the 1980s, this field has made significant advancements in data quality and modeling techniques. In this review, we describe the most common methods for modeling lensing observables, especially imaging data, as they are the most accessible and informative source of lensing observables. We then summarize the primary findings from the literature on the astrophysical and cosmological applications of galaxy-scale lenses. We also discuss the current limitations of the data and methodologies and provide an outlook on the expected improvements in both areas in the near future.
Unveiling Hype Cycle Patterns: Examining 3D Modeling and Printing Adoption Among Secondary School Teachers
Authors: Anđić Branko , Šorgo Andrej , Weinhandl Robert , Maričić Mirjana , Lavicza Zsolt 
Published: November 2024

AbstractDespite numerous studies indicating the positive contribution of 3D modeling and printing (3DMP) in learning settings, its current educational use is still rather limited. For the adoption of 3DMP in classrooms, it is critical to understand the views and perceptions of teachers on such new technology. To better understand how teachers perceive 3DMP, a longitudinal study was conducted with 73 Montenegrin secondary school teachers. The study used the Hype Cycle for Emerging Technologies approach to examine changes in teachers' views and perceptions of 3DMP over four time periods: before a workshop on using 3DMP in teaching, immediately after the workshop, three months later, and one year later. Results showed that teachers were motivated to use 3DMP to keep up with new technological trends, create classroom materials, promote inclusion, and STEM learning, and improve students' learning outcomes. The peak of inflated expectations (immediately after the workshop) is characterized by excessively high teacher expectations of 3DMP in terms of perceived pedagogical impact (PPI), perceived usefulness (PU), and barriers (BAR), while teachers' anxiety (ANX) is low; trough of disillusionment (3 months after the workshop) leads to a significant decrease in teachers' positive views and perceptions of PPI, PU, BAR, but an increase in ANX; the slope of enlightenment (one year after the workshop) leads to a recovery in teachers' positive views and perceptions of 3DMP's contribution to PPI, PU, but also BAR, while ANX significantly decreases. These findings provide recommendations for teacher educators, policymakers, 3DMP developers, and future researchers to better support the use of 3DMP in education.