bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulants Resumption after Warfarin-Related Intracerebral Haemorrhage: The Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)
Authors: Poli Loris , Grassi Mario , Zedde Marialuisa , Marcheselli Simona , Silvestrelli Giorgio , Sessa Maria , Zini Andrea , Paciaroni Maurizio , Azzini Cristiano , Gamba Massimo , Toriello Antonella , Tassi Rossana , Giorli Elisa , Calabrò Rocco , Ritelli Marco , De Vito Alessandro , Pugliese Nicola , Martini Giuseppe , Lanari Alessia , Lodigiani Corrado , Padroni Marina , De Giuli Valeria , Caria Filomena , Morotti Andrea , Costa Paolo , Strambo Davide , Corato Manuel , Pascarella Rosario , Del Sette Massimo , Malferrari Giovanni , Colombi Marina , Padovani Alessandro , Pezzini Alessandro ,   on behalf of the Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) Investigators
Published: February 2018

AbstractWhether to resume antithrombotic treatment after oral anticoagulant–related intracerebral haemorrhage (OAC-ICH) is debatable. In this study, we aimed at investigating long-term outcome associated with OAC resumption after warfarin-related ICH, in comparison with secondary prevention strategies with platelet inhibitors or antithrombotic discontinuation. Participants were patients who sustained an incident ICH during warfarin treatment (2002–2014) included in the Multicenter Study on Cerebral Hemorrhage in Italy. Primary end-point was a composite of ischemic stroke/systemic embolism (SE) and all-cause mortality. Secondary end-points were ischemic stroke/SE, all-cause mortality and major recurrent bleeding. We computed individual propensity score (PS) as the probability that a patient resumes OACs or other agents given his pre-treatment variables, and performed Cox multivariable analysis using Inverse Probability of Treatment Weighting (IPTW) procedure. A total of 244 patients qualified for the analysis. Unlike antiplatelet agents, OAC resumption was associated with a lower rate of the primary end-point (weighted hazard ratio [HR], 0.21; 95% confidence interval [CI], 0.09–0.45), as well as of overall mortality (weighted HR, 0.17; 95% CI, 0.06–0.45) and ischemic stroke/SE (weighted HR, 0.19; 95% CI, 0.06–0.60) with no significant increase of major bleeding in comparison with patients receiving no antithrombotics. In the subgroup of patients with atrial fibrillation, OACs resumption was also associated with a reduction of the primary end-point (weighted HR, 0.22; 95% CI, 0.09–0.54), and the secondary end-point ischemic stroke/SE (weighted HR, 0.09; 95% CI, 0.02–0.40). In conclusion, in patients who have an ICH while receiving warfarin, resuming anticoagulation results in a favorable trade-off between bleeding susceptibility and thromboembolic risk.
International Council for Standardization in Haematology (ICSH) Recommendations for Laboratory Measurement of Direct Oral Anticoagulants
Authors: Gosselin Robert , Adcock Dorothy , Bates Shannon , Douxfils Jonathan , Favaloro Emmanuel , Gouin-Thibault Isabelle , Guillermo Cecilia , Kawai Yohko , Lindhoff-Last Edelgard , Kitchen Steve 
Published: February 2018

AbstractThis guidance document was prepared on behalf of the International Council for Standardization in Haematology (ICSH) for providing haemostasis-related guidance documents for clinical laboratories. This inaugural coagulation ICSH document was developed by an ad hoc committee, comprised of international clinical and laboratory direct acting oral anticoagulant (DOAC) experts. The committee developed consensus recommendations for laboratory measurement of DOACs (dabigatran, rivaroxaban, apixaban and edoxaban), which would be germane for laboratories assessing DOAC anticoagulation. This guidance document addresses all phases of laboratory DOAC measurements, including pre-analytical (e.g. preferred time sample collection, preferred sample type, sample stability), analytical (gold standard method, screening and quantifying methods) and post analytical (e.g. reporting units, quality assurance). The committee addressed the use and limitations of screening tests such as prothrombin time, activated partial thromboplastin time as well as viscoelastic measurements of clotting blood and point of care methods. Additionally, the committee provided recommendations for the proper validation or verification of performance of laboratory assays prior to implementation for clinical use, and external quality assurance to provide continuous assessment of testing and reporting method.
Farbkodierte Duplexsonographie und „Power-Doppler“ in der Perforatorchirurgie – Erhöhung
der Patientensicherheit durch effiziente Planung
Authors: Daigeler Adrien , Schubert Cornelius , Hirsch Tobias , Behr Björn , Lehnhardt Marcus 
Published: February 2018

Zusammenfassung
Einleitung Unterschiedlichste Techniken mit spezifischen Vor- und Nachteilen kommen zur Lokalisation der
Gefäße in der Perforatorchirurgie zum Einsatz. Stabdoppler sind handlich aber ungenau bei der exakten
Perforatorlokalisation. Die Angio-CT ist teuer, zeitaufwendig, strahlenintensiv und invasiv. Die
Duplexsonographie dagegen ist eine zuverlässige, einfach einzusetzende und verfügbare Alternative für die
prä-, intra- und postoperative Gefäßdarstellung. Der Powerdoppler bietet eine noch größere Sensitivität und
kann Gefäße bis 0,5 mm Durchmesser sicher darstellen.
Material und Methoden Der Einsatz von Farb- und Powerdoppler bei der präoperativen Planung wird anhand
von Bildern, die die Identifizierung septaler Gefäße beim ALT, die Darstellung von Empfängergefäßen und die
Planung von gestielten Perforatorlappenplastiken zeigen, illustriert. Es wurden konsekutiv 33 freie
Lappenplastiken (21 ALT, 5 DIEP, 4 FCI, 2 MSAP, 1 tib. post. perforator Lappen) zur Unterschenkel- und
Brustrekonstruktion, sowie 19 gestielte Perforatorlappenplastiken am Rumpf und den Extremitäten zur
Defektdeckung nach Tumor und Trauma für die Auswertung eingeschlossen.
Ergebnisse Die Detektionsgenauigkeit für das Verfahren lag bei 100 %, bedeutend, dass der identifizierte
Perforator in einem Radius von 0,5 cm um die präoperative Markierung lag. Auch der Gefäßverlauf (septal vs.
intramuskulär) wurde zu 100 % korrekt dargestellt. In der Serie trat kein Lappenverlust auf. Es handelt sich
um eine nicht invasive, sichere und kostengünstige, aber zeitaufwendige und untersucherabhängige Technik.
Diskussion Durch die Sichtbarmachung von Arterien und Venen und der exakten Lokalisierung des
Fasziendurchtritts wird das Lappendesign erleichtert. Perforatoren können zentral in den Lappen gelegt, der
Perforatorverlauf speziell bei ALT-Lappen dargestellt und damit aufwendige Präparationen durch den Muskel
vermieden werden.
PPAR-α Agonist Improves Hyperglycemia-Induced Oxidative Stress in Pancreatic Cells by Potentiating Antioxidant Defense System
Authors: Yaribeygi Habib , Mohammadi Mohammad , Sahebkar Amirhossein 
Published: February 2018

Abstract
Background Diabetes-induced oxidative stress has an essential role in pancreatic cells dysfunction. The present study aimed to evaluate whether peroxisome proliferator activated receptor- alpha (PPAR-α) induction by fenofibrate counterbalances oxidative stress in pancreatic cells.
Methods In this in vivo study, male Wistar rats were randomly divided into four groups as normal, normal treated, diabetic and diabetic treated groups (n=6 in each group). Diabetes was induced by a single intravenous injection of streptozotocin (45 mg/kg). Treated animals received fenofibrate for 8 weeks (80 mg/kg/day) orally. At the end of the 8th week, rats were sacrificed and blood samples and pancreas tissues were collected. Then, the content of malondialdehyde (MDA), nitrate (Nox) and glutathione (GLT) and enzymatic activities of catalase (CAT) and superoxide dismutase (SOD) were assessed. D ata were analyzed using two-way ANOVA.
Results Diabetes deteriorated anti-oxidant defense capacity in pancreatic cells by reducing SOD and CAT activities and induced oxidative stress as reflected by increased MDA content and free radicals production (Nox content). Treatment by fenofibrate increased SOD and CAT activities and improved oxidative stress by decreasing pancreatic MDA and Nox levels.
Conclusion Uncontrolled hyperglycemia weakens anti-oxidant defense capacity in pancreatic cells and contributes to oxidative stress. PPAR-α induction by fenofibrate can restore anti-oxidant defense systems and improve diabetes-induced oxidative stress.
Phytochemical and Antinociceptive Investigations of Anemone coronaria Active Part Ameliorating Diabetic Neuropathy Pain
Authors: Raafat Karim , El-Lakany Abdalla 
Published: February 2018

AbstractPhytochemicals might offer economic therapies, which are an alternative especially for low-income developing countries. Anemone coronaria has been used extensively as antineuralgic and antirheumatic in the folk medicine of Lebanon. Thus, the aim of this study was to investigate the antinociceptive potential of A. coronaria and its active principles against diabetic-neuropathy pain in a mouse-model. The study also aimed to achieve a bio-guided fractionation and to isolate the most active principles in A. coronaria herb. Bio-guided fractionation used reversed phase-HPLC, and 1H and 13C NMR for the identification of the most active fraction of A. coronaria, which was rich in alkaloids. This isolated alkaloid rich fraction contained catalin (21.1%), thaliporphine (14.1%), and glaucine (compound 3) (63.4%). A. coronaria extract (50, 100, and 200 mg/kg), the isolated alkaloid rich fraction (70 mg/kg), and glaucine (25, 50, and 100 mg/kg) showed significant reduction in acute and subchronic hyperglycemia, with significant increase in glutathione and catalase levels, along with normalization of HbA1c and LPO levels (n=7 per group, p≤0.05). A. coronaria extract (50, 100, and 200 mg/kg), the isolated alkaloid rich fraction (70 mg/kg), and glaucine (25, 50, and 100 mg/kg) also showed significant antinociceptive amelioration in thermal hyperalgesia pain latencies utilizing hot plate and tail flick tests. The highest doses of A. coronaria extract (200 mg/kg), isolated alkaloid rich fraction (70 mg/kg), and glaucine (100 mg/kg) showed a significant elevation in mechanical allodynia pain thresholds using Von-Frey-filaments. The results revealed that A. coronaria herb along with its most active alkaloid rich fraction and constituent (glaucine) possessed significant antihyperglycemic and antinociceptive potentials. These findings may lead to a future use of A. coronaria in the management of diabetic-neuropathy pain.
Pyrrolopyrimidine, A Multifaceted Scaffold in Cancer Targeted Therapy
Authors: Adel Mai , Serya Rabah , Lasheen Deena , Abouzid Khaled 
Published: February 2018

AbstractPyrrolopyrimidine derivatives represent a class of biologically active heterocyclic compounds which can serve as promising scaffolds that display remarkable biological activities, such as anti-inflammatory, antimicrobial, antiviral and anticancer. In the last few years, several pyrrolopyrimidine derivatives have been approved by the US FDA and in other countries for the treatment of different diseases or are currently in phase I/II clinical trials. Due to their inimitable antioxidant and anti-tumor properties, researchers were inspired to develop novel derivatives for the treatment of different types of cancer. The present review summarizes recent literature up to 2017 on the most recent development in the medicinal chemistry of pyrrolopyrimidine derivatives and their potential as anticancer therapeutics, especially compounds acting as kinase inhibitors.
PI5P4Kγ functions in DTX1-mediated Notch signaling
Authors: Zheng Li , Conner Sean D. 
Published: February 2018

Significance
The Notch signaling pathway performs a vital role in biological processes ranging from stem cell maintenance to cell viability. This highly conserved pathway must be tightly controlled, since defects in signaling can promote disease. The E3 ubiquitin ligase DTX1 has emerged as a key negative regulator of Notch signaling, where Notch ubiquitination by DTX1 is thought to control intracellular sorting decisions of the receptor. Here we show that DTX1 can regulate Notch activity independent of directly ubiquitinating the receptor, suggesting that DTX1 targets other factors involved in Notch transport. Using an activity-based screen for DTX1 substrates, we identify PI5P4Kγ, a lipid kinase, and discover that PI5P4Kγ and DTX1 have opposing activities in regulating Notch transit through recycling endosomes.
Contribution of NIH funding to new drug approvals 2010–2016
Authors: Galkina Cleary Ekaterina , Beierlein Jennifer M. , Khanuja Navleen Surjit , McNamee Laura M. , Ledley Fred D. 
Published: February 2018

Significance
This report shows that NIH funding contributed to published research associated with every one of the 210 new drugs approved by the Food and Drug Administration from 2010–2016. Collectively, this research involved >200,000 years of grant funding totaling more than $100 billion. The analysis shows that >90% of this funding represents basic research related to the biological targets for drug action rather than the drugs themselves. The role of NIH funding thus complements industry research and development, which focuses predominantly on applied research. This work underscores the breath and significance of public investment in the development of new therapeutics and the risk that reduced research funding would slow the pipeline for treating morbid disease.
Land-use and land-cover change shape the sustainability and impacts of protected areas
Authors: Tesfaw Anteneh T. , Pfaff Alexander , Golden Kroner Rachel E. , Qin Siyu , Medeiros Rodrigo , Mascia Michael B. 
Published: February 2018

SignificanceEmerging evidence shows that the boundaries of protected areas (PAs) and their level of protection regularly change, yet little is known regarding the underlying causes of these legal changes and their impacts on ecosystems. For PA degazettements (i.e., protection removals) in the state of Rondônia in the Brazilian Amazon we show that the PAs less effective in stemming deforestation are more likely to be degazetted. For those already deforested PAs degazettement had limited, if any, additional impact on deforestation. Consistent with the scientific literature recognizing that governance shapes conservation outcomes, governance that improves PA outcomes also improves their legal durability. Our evidence on such relationships suggests directions for research and the need for policymakers to reexamine conventional wisdom regarding PAs.
Epitope-specific monoclonal antibodies to FSHβ increase bone mass
Authors: Ji Yaoting , Liu Peng , Yuen Tony , Haider Shozeb , He Jiahuan , Romero Raquel , Chen Hao , Bloch Madison , Kim Se-Min , Lizneva Daria , Munshi Lubna , Zhou Chunxue , Lu Ping , Iqbal Jameel , Cheng Zhen , New Maria I. , Hsueh Aaron J. , Bian Zhuan , Rosen Clifford J. , Sun Li , Zaidi Mone 
Published: February 2018

Significance
We have addressed the question whether osteoporosis and obesity, which often occur concurrently in postmenopausal women, can be targeted by a single agent. We have shown previously that the reproductive hormone FSH, the levels of which rise after menopause, regulates both body fat and bone mass. We now show that blocking FSH action using two purposefully designed epitope-specific antibodies protects against bone loss in mice. This positions both FSH antibodies as lead molecules for clinical development toward future use in people.
Borrowed Spanish discourse markers in narrative
Authors: Brody Mary Jill 
Published: February 2018

Abstract
This pilot study examines texts from three generations of speakers of Tojol-ab’al, a Mayan language that has been in long-term contact with Spanish, to determine the influence from Spanish on Tojol-ab’al narrative discourse. Discourse markers borrowed from Spanish and those indigenous to Tojol-ab’al are examined to determine discourse structure. Discourse markers borrowed from Spanish appear frequently even in the speech of the oldest, monolingual generation. Although the youngest generation uses many more words (nouns, verbs) borrowed from Spanish than do the earlier generations, narrative discourse structure, as indicated by the use of both borrowed and indigenous discourse markers, remains substantially the same through time.
El futuro es perifrástico
Authors: Kyzar Kendall 
Published: February 2018

Abstract
In this study of the expression of futurity in the Spanish of Mexicans residing in the Baton Rouge, Louisiana, metropolitan area, I explore the distribution of the variants of futurity – the morphological future (MF), the periphrastic future (PF) and the simple present (SP) – and the constraints conditioning their occurrence. The results indicate that the PF registers the highest rate of occurrence with a frequency of 72.0% to the detriment of the MF. In comparison with other studies (cf. Gutiérrez 1995; Orozco 2007a), the PF is the most favored variant at the expense of the others. The type of verb, as reported in previous studies (cf. Orozco 2005, 2007a), is the linguistic constraint that most strongly influences the expression of futurity. Regarding social constraints, level of education conditions the use of the future. The lack of statistical significance for gender suggests that women and men have similar sociolinguistic behaviors. This opens the possibility of exploring other linguistic variables in other bilingual Mexican communities to determine whether the social trends that are found are limited to the expression of futurity or to the communities under study.
Report on the measurement results for the EURAMET 658 extension: project to examine underlying parameters in radiance scale realisation
Authors: McEvoy Helen , Martin Maria Jose , Steiner Anton , Schreiber Ekkehard , Girard Ferruccio , Battuello Mauro , Sadli Mohamed , Ridoux Pascal , Gutschwager Berndt , Hollandt Joerg , Diril Ahmet , Pehlivan Özlem 
Published: February 2018

This report describes the measurement procedures and participant results for the EURAMET project 658 extension—'project to examine underlying parameters in radiance temperature scale realisation from 156 °C to 1000 °C', with particular emphasis on the results of the variable temperature and fixed point blackbody measurements for the justification of radiation thermometry CMCs.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCT, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Feeding habits estimated from weight-related isotope variations of mesopelagic fish larvae in the Kuroshio waters of the northeastern East China Sea
Authors: Mei Weiping , Umezawa Yu , Wan Xin , Yuan Jinghan , Sassa Chiyuki 
Published: February 2018

Abstract
Bulk carbon and nitrogen stable isotope (SI) ratios (δ13C and δ15N) were analysed to investigate the feeding habits of six taxa of mesopelagic fish larvae inhabiting the Kuroshio waters of the northeastern East China Sea. Large variation in tissue SI during early larval periods suggested maternal effects from parent fishes, and non-selective feeding on a variety of plankton species due to poor swimming ability. The similarity between SI ratios measured in larval tissues and those estimated for eggs of an “income breeder” in the spawning area support an “income breeder” strategy in Diaphus slender type and Vinciguerria nimbaria, while Lipolagus ochotensis seemed to show “capital breeder”-like characteristics. SI ratios of the fish larvae studied became relatively constant at species-specific body dry-weights (0.5–1.0 mg), probably due to the commencement of selective feeding, meaning SI ratios during late larval periods could be used for trophic position analysis. There was great overlap (44.6–76.5%) in trophic niche among the larval fishes within the same taxonomic family of Myctophidae. Even if principal diet components cannot be identified with gut contents analyses, diet information from other fish species occupying a similar isotopic niche can thus improve our understanding of the diets of larval fishes.
The first in situ observation of torsional Alfvén waves during the interaction of large-scale magnetic clouds
Authors: Raghav Anil N , Kule Ankita 
Published: February 2018

Abstract
The large-scale magnetic cloud such as coronal mass ejections (CMEs) is the fundamental driver of the space weather. The interaction of the multiple-CMEs in interplanetary space affects their dynamic evolution and geo-effectiveness. The complex and merged multiple magnetic clouds appear as the in situ signature of the interacting CMEs. The Alfvén waves are speculated to be one of the major possible energy exchange/dissipation mechanism during the interaction. However, no such observational evidence has been found in the literature. The case studies of CME–CME collision events suggest that the magnetic and thermal energy of the CME is converted into the kinetic energy. Moreover, magnetic reconnection process is justified to be responsible for merging of multiple magnetic clouds. Here, we present unambiguous evidence of sunward torsional Alfvén waves in the interacting region after the super-elastic collision of multiple CMEs. The Walén relation is used to confirm the presence of Alfvén waves in the interacting region of multiple CMEs/magnetic clouds. We conclude that Alfvén waves and magnetic reconnection are the possible energy exchange/dissipation mechanisms during large-scale magnetic clouds collisions. This study has significant implications not only in CME-magnetosphere interactions but also in the interstellar medium where interactions of large-scale magnetic clouds are possible.