bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Serological Biomarkers of Treatment’s Response in Multiple Sclerosis Patients Treated Continuously with Interferonβ-1b for More than a Decade
Authors: Bărcuţean Laura Iulia , Romaniuc Andreea , Maier Smaranda , Bajko Zoltan , Moţăţăianu Anca , Adina Huţanu , Simu Iunius , Andone Sebastian , Bălaşa Rodica 
Published: September 2018

Introduction:
We evaluated the peripheral immune panel of Multiple Sclerosis (MS) patients
treated for more than 10 years with interferon-beta1b (IFNβ-1b) and aimed to identify possible
biomarkers of treatment response.

Material and Methods:
Serum samples from 70 MS patients treated with IFNβ-1b more than a decade
were analysed for 15 cytokines, that were correlated with the disability score, annual relapse ratio
(ARR): the total number of relapses-ARR_0, relapse on treatment-ARR_1 and demographic data. Two
groups were defined based on the levels of disability, calculated using the Expanded Disability Status
Scale (EDSS): G1 – recurrent-remissive and G2 – secondary-progressive. Furthermore, we split the
patients based on gender (G1_f, G1_m, G2_f, G2_m).

Results:
The ARR was reduced after treatment was instituted. We found positive correlations between
IL_25 and EDSS in G1_f and G2_f, tumor necrosis factor α (TNFα) and ARR_1 and ARR_0 in G1,
and IL_17F with ARR_1. Negative correlations were for IL_25 and ARR_0 and ARR_1. SCD40L intensely
positively correlated with IL_31 in G1 and G2.

Conclusion:
After more than a decade of treatment, IFNβ-1b offers good results by reducing relapses
and slowing disability progression. Several biomarkers can be used to assess the patient’s response.
High levels of IL_17 and TNFα will indicate a more active form of the disease. IL-25 may exert a
positive influence in male MS patients and should be considered for future studies, together with the
co-modulation between sCD40L and IL_31. Our method allowed us to screen the peripheral immune
panel and can be used for assessing the peripheral levels of the above-mentioned cytokines.
Encapsulation of Reactive Nanoparticles of Aluminum, Magnesium, Zinc, Titanium, or Boron within Polymers for Energetic Applications
Authors: Zeng Wenhui , Nyapete Calvin O. , Benziger Alexander H.H. , Jelliss Paul A. , Buckner Steven W. 
Published: September 2018

Background:
There is increasing academic and industrial interest in fabricating reactive
metal and metalloid nanoparticles for a number of energetics applications.

Objective:
Because of inherent thermodynamic instability, the greatest challenge for producing such
metal nanoparticles is to kinetically stabilize their high surface areas toward reactive atmospheric
constituents. Such stabilization can effectively produce nanocomposite materials that retain their high
energy content or other useful properties with a respectable shelf-life. The primary focus is to summarize
methods of synthesis and characterization of these energetically valuable nanoparticles.

Method and Results:
Method and Results: A popular and convenient method to passivate and protect reactive metal nanoparticles
is to either graft pre-assembled polymer molecules to the nanoparticle surface or use the reactive
nanoparticle surface to initiate and propagate oligomer or polymer growth.

Conclusion:
Reactive nanoparticles composed of aluminum, magnesium, zinc, titanium, or boron
may be effectively passivated, capped, and protected by a variety of organic polymers. Such treatment
mitigates degradation due to atmospheric reaction, while retaining the unique properties associated
with the metal-polymer nanocomposites.
Gambaran kualitas hidup pasien lansia pengguna gigi tiruan lepasan di RSGM Unpad
Authors: Melati Cindy Annisa , Susilawati Sri , Rikmasari Rasmi 
Published: September 2018

Description of quality of life on elderly patients with removable denture at RSGM Unpad. The elderlies are prone to the process of the gradual decreasing ability of the tissue for self-healing. This process greatly affects the dental structure and periodontal tissue leading to tooth decay. When it is not properly treated, it may disturb oral functions and activities influencing their life quality. This research, therefore, aims to obtain the description of quality of life on elderly patients with removable denture at the Prosthodontic Clinic RSGM Unpad. Research was conducted with a descriptive method using the consecutive technique sampling method. Data were collected from 31 elderly patients with removable denture at the Prosthodontic Clinic RSGM Unpad and quality of life was measured by GOHAI questionnaire. The results showed that the dimensions of physical function fell into the adequate criteria, while the dimensions of pain and inconvenience and psychosocial aspects were considered good. It can be concluded that the general quality of life on elderly patients with removable denture at the Prosthodontic Clinic RSGM Unpad were good. ABSTRAKPada lansia terjadi suatu proses menghilangnya secara perlahan kemampuan jaringan untuk memperbaiki diri yang disebut proses menua. Proses tersebut berpengaruh terhadap gigi dan jaringan periodontal sehingga mengakibatkan kehilangan gigi. Jika kehilangan gigi tidak diberi perawatan dapat mengganggu fungsi dan aktivitas rongga mulut sehingga akan mempunyaidampak pada kualitas hidupnya. Penelitian ini bertujuan untuk mengetahui gambaran kualitas hidup pasien lansia pengguna gigi tiruan lepasan di Instalasi Prostodonsia RSGM Unpad. Jenis penelitian adalah deksriptif dengan teknik pengambilan sampel menggunakan teknik populasi terjangkau dengan minimal sampling. Data dikumpulkan dari 31 pasien lansia pengguna gigi tiruan lepasan di Instalasi Prostodonsia RSGM Unpad. Kualitas hidup diukur dengan menggunakan kuesioner GOHAI. Hasil penelitian menunjukkan bahwa dimensi fungsi fisik berada pada kriteria cukup, dimensi nyeri dan ketidaknyamanan berada pada kriteria baik dan dimensi aspek psikososial berada pada kriteria baik. Kesimpulan penelitian menunjukkan kualitas hidup pasien lansia pengguna gigi tiruan lepasan di Instalasi Prostodonsia RSGM Unpad dikategorikan baik.
Perbandingan porselen kedokteran gigi swa-sintesis berbahan baku pasir felspar Pangaribuan dan Sukabumi
Authors: Gunawan Joseph , Taufik Dede , Takarini Veni , Hasratiningsih Zulia 
Published: September 2018

Comparison self-synthesized dental porcelain between feldspar from Pangaribuan and Sukabumi. Dental porcelain material as one of the esthetic indirect restorations in Indonesia is mostly imported. In fact, Indonesia is really rich of natural raw materials, including feldspar, silica, and kaolinite. The aim of this study is to synthesize the dental porcelain made from Indonesia’s two different originates, which are Pangaribuan and Sukabumi. This study was prepared by fritting and sintering the mixture of 65% wt feldspar (from Sukabumi and Pangaribuan), 25% wt silica, 5% wt kaolinite, and 5% wt potassium salt. The porcelains obtained were evaluated using X-Ray Diffraction (XRD). The results revealed that quartz and leucite were found in the composition of Pangaribuan sand that successfully showed more translucencies compared to Sukabumi sand which only imparted quartz on its component. This study shows that dental porcelain from Pangaribuan sand is successfully self-synthesized, on the other hand Sukabumi sand has not been successfully synthesized. These findings develop on a good prospect of esthetic dental porcelain made from Indonesian natural sand. ABSTRAKBahan porselen kedokteran gigi sebagai salah satu restorasi indirek estetik di Indonesia kebanyakan didatangkan dari luar negeri. Indonesia sebenarnya sangat kaya dengan bahan baku porselen kedokteran gigi seperti felspar, silika, dan kaolin. Tujuan penelitian ini adalah melakukan sintesis porselen kedokteran gigi dari 2 jenis pasir alam Indonesia yaitu Pangaribuan dan Sukabumi. Komposisi yang digunakan yaitu 65% wt felspar, 25% wt silika, 5% wt kaolin, dan 5% wt garam kalium, dicampur kemudian dilakukan fritting serta sintering. Dua komposisi porselen dibuat dengan bahan dasar berbeda yaitu felspar dari Pangaribuan dan Sukabumi. Kedua porselen yang telah disintering kemudian dievaluasi menggunakan X-Ray Diffraction (XRD). Hasilnya adalah kuarsa dan leusit ditemukan pada porselen dengan komposisi pasir Pangaribuan yang juga memberikan hasil lebih translusen secara visual dibandingkan dengan porselen dengan komposisi pasir Sukabumi yang hanya memperlihatkan hasil kuarsa. Hal ini menunjukkan bahwa porselen dengan komposisi bahan dasar pasir Pangaribuan berhasil disintesis dibandingkan komposisi bahan dasar pasir Sukabumi.Penemuan ini dapat memberikan peluang yang baik dalam pembuatan porselen kedokteran gigi yang berasal dari pasir alam Indonesia.
Gut Microbiota Differs in Composition and Functionality Between Children With Type 1 Diabetes and MODY2 and Healthy Control Subjects: A Case-Control Study
Authors: Leiva-Gea Isabel , Sánchez-Alcoholado Lidia , Martín-Tejedor Beatriz , Castellano-Castillo Daniel , Moreno-Indias Isabel , Urda-Cardona Antonio , Tinahones Francisco J. , Fernández-García José Carlos , Queipo-Ortuño María Isabel 
Published: September 2018

OBJECTIVE
Type 1 diabetes is associated with compositional differences in gut microbiota. To date, no microbiome studies have been performed in maturity-onset diabetes of the young 2 (MODY2), a monogenic cause of diabetes. Gut microbiota of type 1 diabetes, MODY2, and healthy control subjects was compared.

RESEARCH DESIGN AND METHODS
This was a case-control study in 15 children with type 1 diabetes, 15 children with MODY2, and 13 healthy children. Metabolic control and potential factors modifying gut microbiota were controlled. Microbiome composition was determined by 16S rRNA pyrosequencing.

RESULTS
Compared with healthy control subjects, type 1 diabetes was associated with a significantly lower microbiota diversity, a significantly higher relative abundance of Bacteroides, Ruminococcus, Veillonella, Blautia, and Streptococcus genera, and a lower relative abundance of Bifidobacterium, Roseburia, Faecalibacterium, and Lachnospira. Children with MODY2 showed a significantly higher Prevotella abundance and a lower Ruminococcus and Bacteroides abundance. Proinflammatory cytokines and lipopolysaccharides were increased in type 1 diabetes, and gut permeability (determined by zonulin levels) was significantly increased in type 1 diabetes and MODY2. The PICRUSt analysis found an increment of genes related to lipid and amino acid metabolism, ABC transport, lipopolysaccharide biosynthesis, arachidonic acid metabolism, antigen processing and presentation, and chemokine signaling pathways in type 1 diabetes.

CONCLUSIONS
Gut microbiota in type 1 diabetes differs at taxonomic and functional levels not only in comparison with healthy subjects but fundamentally with regard to a model of nonautoimmune diabetes. Future longitudinal studies should be aimed at evaluating if the modulation of gut microbiota in patients with a high risk of type 1 diabetes could modify the natural history of this autoimmune disease.
Contact with mental health services after medically verified self-harm: A prospective data linkage study
Authors: Young Jesse , Borschmann Rohan , Kinner Stuart 
Published: September 2018

IntroductionHigh rates of self-harm resulting in acute health service contact have been observed in adults released from prison. Contact with health services due to self-harm is a key intervention opportunity to prevent deleterious health outcomes. Little is known about subsequent mental health service contact after discharge from acute health services.
Objectives and ApproachWe aimed to describe mental health service contact after discharge from acute health service contacts following self-harm in a representative sample of adults released from prison. Ambulance, emergency department (ED), hospital inpatient and ambulatory mental health service records were probabilistically linked to pre-release interview data. Self-harm events after release were identified from ICD codes and coded from case notes in ambulance, ED, and hospital records. We calculated the time between discharge from ambulance, ED, or hospital after self-harm and subsequent contact with mental health services. Factors predicting the likelihood of mental health service contact were examined using multivariate logistic regression.
ResultsOf 1307 adults released from prison, 108 (8.3%) experienced 218 self-harm events resulting in acute health service use in the community. Of these presentations, 0%, 59%, and 50% of discharges from ambulance attendances, ED and hospital, respectively, had subsequent contact with a specialist mental health service within 7 days of that acute service contact. Mental health service contact within 7 days of acute service contact was positively associated with being female (adjusted odds ratio [AOR]: 3.27; 95%CI: 1.26-8.47) and being identified by prison staff as at risk for self-harm (AOR: 3.34; 95%CI: 1.29-8.62), and was negatively associated with dual diagnosis (AOR: 0.19: 95%CI: 0.06-0.61), substance use disorder only (AOR: 0.13; 95%CI: 0.04-0.48) and physical health functioning (AOR: 0.96; 95\%CI: 0.92-0.99).
Conclusion/ImplicationsAlmost half of adults with a recent history of incarceration discharged from acute health service after self-harm did not receive timely specialist mental health care. Improved integration of acute health services and ambulatory mental health services could improve outcomes for adults who present with self-harm.
When the Census Comes Marching In: Challenges and Successes in Linking Individual-Level Census Records to the Utah Population Database
Authors: Smith Ken , Fraser Alison 
Published: September 2018

IntroductionThe availability of historic, individual-level census records in the United States has grown in recent years. With access to identifiers, it is possible to link these records to existing databases. The performance of and strategy for these linking efforts is not well characterized.
Objectives and ApproachThe Utah Population Database (UPDB), launched in 1975, is a population registry comprising comprehensive data from genealogies, medical/vital records, and numerous administrative and demographic records spanning the past two centuries. UPDB initially did not hold individual-level US Census records until now. UPDB has massive volumes of identifiers that we have cleaned and it therefore represents a “gold standard” representation of Utah’s population. The objective here is to describe the methods used and the record linking performance applied to census records that we have linked to the UPDB for persons appearing in the 1880, 1900, 1910, 1920, 1930 and 1940 censuses.
ResultsWe collaborated with FamilyTree, Ancestry, and IPUMS (University of Minnesota) for keying and preparing data from the 1880-1940 censuses. We then linked these records to the UPDB using probabilistic record linking methods and manual review. Linking rates by census year varied by the quality of records and electronic data capture and by specific Census fields for a given census. Data quality was somewhat lower for the 1910 and 1940 censuses and hence they had lower linking rates (66.9% and 70.4, respectively). Household heads enjoyed higher linking rates (72% was the lowest, in 1940). We used household heads to help guide links to offspring and spouses whose linking rates exceeded 75% in general. Non-family members and single men linked at much lower rates (<50%).
Conclusion/ImplicationsThis study found that linking census records to an existing population registry is feasible and with relative success. Using household/genealogy structure of the census is useful when linking to the genealogies in the UPDB. These links allow studies of effects of early life conditions on later life outcomes.
Interkoneksi Nilai-Nilai Huma Betang Kalimantan Tengah dengan Pancasila
Authors: AS Pelu Ibnu Elmi , Tarantang Jefry 
Published: September 2018

<div><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td align="left" valign="top"><p class="AbstractText"><em>Huma betang </em> is a typical traditional house inhabited by Dayak people. The life intertwined from the residents of the Betang Huma is safe, peaceful and warmly in differences. This research is a qualitative research with an empirical and normative approach focusing on the philosophy of <em>Huma betang </em> and its relationship to Pancasila. This study reveals that Pancasila can be seen from the foundation of life of Central Kalimantan people, namely <em>Garing Hatungku Tungket Langit, isen mulang, Hupungkal Lingu Nalatai Hapangajan Karendem Malempang, dan Belom Bahadat.</em><em> </em>If it is seen from the relationships and its interrelations, there is an interconnection of the <em>Huma betang </em> values of the Central Kalimantan Dayak people with the Pancasila philosophy with the spirit of togetherness in difference of Unity in Diversity in the life of the nation and state.</p></td></tr></tbody></table></div>
Pola Keruangan Budaya Oloh Salam Masyarakat Kalimantan Tengah dengan Pendekatan Geospasial
Authors: Fitriana Evi 
Published: September 2018

AbstrakIslam masuk ke Indonesia mampu beradaptasi dengan kebudayaan lokal. Proses penyampaian islam dengan cirinya yang apresiatif dengan budaya lokal serta memihak dengan warga setempat menyebabkan Islam diterima sebagai agama baru. Penelitian ini bertujuan untuk memetakan budaya Oloh Salam, kebudayaan lokal suku Dayak, sejarah persebaran islam di Kalimantan Tengah dan deskripsi budaya Oloh Salam. Oloh salam adalah orang-orang Dayak yang memilih memeluk agama Islam namun masih terdapat sisa-sisa kepercayaan primitif tercampur dengan unsur-unsur agama Islam. Beberapa aspek budaya oloh salam yang khas meliputi upacara kehidupan disebut juga gawi belum dan upacara kematian atau gawi matei serta aspek seni. Kekhasan ini merupakan keunikan tersendiri bila ditinjau berdasarkan letak geografisnya yaitu di Pulau Kalimantan. Metode penelitian menggunakan studi pustaka, data dan informasi kemudian diolah mengunakan pendekatan geospasial dengan overlay peta. Hasil overlay menjelaskan pola keruangan budaya Oloh Salam membentuk pola memanjang sungai dan pantai. Hal ini menunjukkan bahwa persebaran islam dimulai dari pesisir kemudian berlayar melalui sungai untuk memperluas ajaran islam khususnya di Kalimantan Tengah. Kata kunci: budaya, Oloh Salam, pola keruangan AbstractIslam entry into Indonesia is able to adapt to local culture. The process of conveying Islam with cultural approach makes Islam readily accepted by local communities. Islam that is appreciative with local culture and taking sides with local people causes Islam to be accepted as a new religion. This Study aims to determine the spatial pattern Oloh Salam culture, local culture of Dayak, history of the Islamic spread in Central Kalimantan, and definition of Oloh Salam culture. Dayak™s culture in Central Kalimantan who has follow Islamic religion is called Oloh Salam. The conversion process of Dayak etnic from their religion become Islam is the impact of the opening of river routes from upstream to downstream. Some typical cultural aspects include the ceremony of life is also called gawi and death ceremony or gawi matei. The research method used in the literature study, data and information obtained then processed using geospatial approach by overlaying the map. The results showed that the spatial pattern of the Oloh Salam culture formed a longitudinal pattern of rivers and beaches. This proves that, the spread of Islam began in the coastal areas then sailed through the river channel to expand the spread of Islam to spread to remote areas especially in Central Kalimantan. Key words: spatial pattern, culture, Oloh Salam
Tingkat Kesiapan Masyarakat Lokal Terhadap Pengembangan Community Based Tourism (CBT) di Kabupaten Samosir
Authors: Sugiharto Sugiharto , Delita Fitra , Sidauruk Tumiar 
Published: September 2018

Kabupaten Samosir memiliki potensi besar dalam industri pariwisata. Pengembangan sektor pariwisata di Kabupaten Samosir tentunya akan berdampak pada kehidupan masyarakat lokal terutama dibidang ekonomi, budaya (culture), sosial masyarakat dan lingkungan. Tujuan utama penelitian ini yaitu menganalisis tingkat kesiapan masyarakat lokal terhadap pengembangan pariwisata berbasis masyarakat (CBT) di Kabupaten Samosir. Pengukuran kesiapan masyarakat dengan skala likert yang terbagi atas aspek perencanaan, pengelolaan dan evaluasi pengembangan wisata berbasis masyarakat. Kemudian data dianalisis menggunakan SPSS v.20 dengan alat analisis One-way ANOVA. Hasil penelitian menunjukkan terdapat perbedaan tingkat kesiapan masyarakat pada aspek perencanaan, pengelolaan dan evaluasi pengembangan wisata berbasis masyarakat di Kabupaten Samosir. Faktor utama yang mempengaruhi tingkat kesiapan masyarakat lokal dalam pengembangan CBT di Kabupaten Samosir yaitu pendidikan dan umur.Kata kunci: kesiapan masyarakat, CBT, Kabupaten Samosir
EVALUASI KESESUAIAN LAHAN UNTUK TANAMAN JAGUNG DI KECAMATAN BINJAI UTARA
Authors: S Julinar Veronika , Elfayetti Elfayetti 
Published: September 2018

Penelitian ini bertujuan untuk mengetahui karakteristik lahan pertanian dilihat dari suhu, topografi, KTK, pH, N-total, P2O5, dan K2O untuk tanaman jagung yang ada di Kecamatan Binjai Utara. Penelitian ini dilakukan di Kecamatan Binjai Utara tahun 2016. Populasi dalam penelitian ini adalah seluruh areal yang ditanami tanaman jagung dengan luas 235 ha di Kecamatan Binjai Utara. Sampel ditentukan dengan Purposive Sampling (metode pengambilan sampel yang tidak bersifat acak). Dimana Sampel diambil berdasarkan satuan lahan yang diperoleh dari gabungan beberapa peta (overlay peta). Teknik pengumpulan data yang digunakan adalah teknik observasi, teknik pengukuran langsung dan dokumentasi. Data dianalisis secara deskriptif kualitatif. Hasil penelitian menunjukkan bahwa: (1) pada sampel tanah Kelurahan Jati Karya dengan KTK 16,36, pH 5,3, unsur Nitrogen 0,09%, Posfor 5,75 ppm, Kalium 0,2 me/100gr. Sampel tanah Jati Utomo dengan KTK 13,38, pH 5,5, unsur Nitrogen 0,06%, Posfor 6,25 ppm, Kalium 0,2 me/100gr. Sedangkan pada sampel tanah Cengkeh Turi dengan KTK 16,50, pH 6,3, unsur Nitrogen 0,08%, Posfor 6,75 ppm, dan Kalium 0,2 me/100gr. (2) Kesesuaian lahan pada Kecamatan Binjai Utara menunjukkan kelas kesesuaian lahan N2 (tidak sesuai permanen).Kata kunci : kesesuaian lahan, jagung, binjai utara
KESIAPAN GURU GEOGRAFI DALAM PENERAPAN STANDAR PROSES DAN STANDAR PENILAIAN SESUAI KURIKULUM 2013 DI SMA NEGERI 3 MEDAN
Authors: Lubis Syahdana Sahin , Berutu Nurmala 
Published: September 2018

Penelitian ini bertujuan untuk mengetahui : (1) penerapan standar proses sesuai kurikulum 2013 di SMA Negeri 3 Medan; (2) penerapan standar penilaian sesuai kurikulum 2013 di SMA Negeri 3 Medan. Penelitian ini dilaksanakan di SMA Negeri 3 Medan yang terletak di Jl. Budi Kemasyarakatan No. 3 Kelurahan Pulo Brayan Kota Kecamatan Medan Barat Kota Medan. Populasi dalam penelitian ini adalah seluruh guru geografi di SMA Negeri 3 Medan yang berjumlah 2 orang dan sampel dalam penelitian ini adalah sampel total (total sampling) yaitu seluruh guru geografi yang ada di SMA Negeri 3 Medan yang berjumlah 2 orang. Teknik pengumpulan data dilakukan dengan teknik observasi, dan studi dokumenter, serta teknik analisis data yang digunakan yaitu analasis deskriptif. Hasil penelitian menunjukkan : (1) Kesiapan guru geografi dalam penerapan standar proses sesuai kurikulum 2013 tergolong sangat tidak siap (57,22), (2) Kesiapan guru geografi dalam penerapan standar penilaian diperoleh nilai untuk penilaian autentik sesuai dengan kurikulum 2013 tergolong sangat tidak siap (33,05). Dengan demikian Kesiapan Guru Geografi Dalam Penerapan Standar Proses dan Standar Penilaian Sesuai Kurikulum 2013 di SMA Negeri 3 Medan berdasarkan Standar Proses dan Standar Penilaian tergolong Sangat Tidak Siap.Kata kunci : standard proses, standard penilaian, kurikulum 2013