bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does race predict survival for women with invasive breast cancer?
Authors: Walsh Siún M. , Zabor Emily C. , Stempel Michelle , Morrow Monica , Gemignani Mary L. 
Published: June 2019

BackgroundBlack women with breast cancer have lower survival rates and higher recurrence rates in comparison with white women. This study compared treatment and survival outcomes for black and white women at a highly specialized tertiary care cancer center.MethodsAn institutional review board–approved, retrospective institutional database review was performed to identify all black women treated for invasive breast cancer between 2005 and 2010. Women with a prior history of breast cancer, stage IV cancer, or bilateral breast cancer were excluded. White women had similar exclusion criteria applied and were then matched to black women 1:1 by age and diagnosis year. Clinicopathologic and treatment variables were compared by race. Kaplan‐Meier methodology was used to estimate overall survival (OS) and disease‐free survival (DFS); a multivariable analysis was conducted with Cox regression models.ResultsThe study group consisted of 1332 women (666 black). The median tumor size was larger in black women (1.6 vs 1.3 cm; P < .001). Black women had more nodal disease (41.1% vs 32%; P < .001) and had tumors that were more frequently an estrogen receptor–negative (32.9% vs 15%; P < .001), progesterone receptor–negative (47.1% vs 30.2%; P < .001), or triple‐negative (TN) subtype (24% vs 8.9%; P < .001) in comparison with white women. Black women also had inferior DFS and OS; race was not an independent prognostic indicator in the multivariable analysis.ConclusionsBlack women had more advanced disease and adverse prognostic indicators at diagnosis, but race was not an independent predictor of outcome. Black women were significantly more likely to have TN breast cancer. Further research is necessary to understand the differences in tumor biology associated with race.
In Situ Synthesis of Well‐Ordered Magnetic Palladium Catalyst Triggered by Supramolecular Chaotropic Effect of Boron Cluster
Authors: Qi Bin , Wu Chenchen , Liu Jun , Zhang Haibo 
Published: June 2019

AbstractSupramolecular chaotropic effect is a new topic in the field of nanocomposites (NCs) fabrication. Herein, this strategy was applied to prepare magnetic Fe3O4@γ‐CD‐boron cluster (SSAs)@Pd NCs in situ via a facile two‐step process, involving a supramolecular assembly process on Fe3O4 NPs and in situ formation of Pd nanoparticles. Boron clusters ([closo‐B12H12]2−) played a dual role in this synthetic process, and were used as a superchaotropic anion to interact with γ‐CD to form supramolecular self‐assemblies (SSAs), as well as efficient reductant to in situ reduce Pd(II) to Pd(0). Ascribed to the electrostatic attraction of boron clusters and capping effect of γ‐CD, ultrafine Pd nanoparticles were successfully coated on the Fe3O4@SSAs composites to fabricate Fe3O4@SSAs@Pd NCs. A combination of UV spectra, Fourier transform infrared spectroscopy, X‐ray photoelectron spectroscopy, transmission electron microscopy, X‐ray diffraction, and energy dispersive X‐ray spectroscopy was used to verify the formation of these magnetic Pd NCs. The ultrafine metallic Pd NPs imparted the magnetic composites with great potential in catalysis, especially for Suzuki coupling reactions. Remarkably, the obtained Fe3O4@SSAs@Pd NCs showed good catalytic performance, high stability and easy recycling via an external magnet.
Association between early parental deprivation and cellular immune function among adults in rural Fujian, China
Authors: Yazawa Aki , Inoue Yosuke , Cai Guoxi , Tu Raoping , Huang Meng , He Fei , Chen Jie , Yamamoto Taro , Watanabe Chiho 
Published: June 2019

AbstractThis study investigated the role of childhood parental deprivation in the association between quality of life (QOL) and the Epstein–Barr virus (EBV) antibody titer, a marker of cellular immune functioning, using data from 734 adults living in seven communities in rural Fujian, China. Parental deprivation was defined if either of their parents had died, divorced, or left them for migratory work for more than 1 year before they turned (a) 16 years of age (childhood and adolescence), or (b) 3 years of age (early childhood). A mixed‐effects regression analysis with a random effects model revealed that parental deprivation during early childhood was positively associated with the EBV antibody titer (coefficient = 0.33, p = 0.007), whereas parental deprivation during the first 16 years was not. Further analysis incorporating an interaction term between QOL and parental deprivation revealed a significant interaction between QOL and parental deprivation during early childhood; a significant association between QOL and the EBV antibody titer was found only among those who reported parental deprivation during early childhood. This study suggests that parental deprivation during the period of immune system development may be linked with physiological responses to stressors later in life.
Association between insulin resistance and haematological parameters: A cohort study from adolescence to adulthood
Authors: Ferreira Daniela , Severo Milton , Araújo Joana , Barros Henrique , Guimarães João T. , Ramos Elisabete 
Published: June 2019

AbstractBackgroundThe aim of this study was to quantify the relationship between insulin resistance and haematological parameters from adolescence to adulthood.MethodsParticipants from the EPITeen cohort were evaluated at 13, 17, and 21 years, through standardized procedures. A fasting blood sample was obtained, and insulin resistance was evaluated by the homeostatic model assessment (HOMA‐IR). The cross‐sectional association between HOMA‐IR and haematological parameters at 21 years was quantified in 1671 participants by multivariate linear regression coefficients (β) and 95% confidence intervals (95%CI). For the longitudinal analysis (n = 496), trajectories of insulin and glucose were estimated using model‐based clustering, and haematological parameters were compared according to trajectories using ANOVA.ResultsAt 21 years, after adjustment for BMI, positive associations (β [95%CI]) were found between HOMA‐IR and red blood count (0.05 [0.03;0.07] in females; 0.02 [0.00;0.04] in males); and haematocrit (0.29 [0.12;0.46] in females; 0.21 [0.04,0.38] in males). In females, HOMA‐IR was inversely associated with packed cell volume (PCV) (−0.35 [−0.66;−0.05]) and iron levels (−3.98 [−6.94,−1.03]) but positively associated with white blood cells (0.31 [0.19;0.43]) and platelets (7.66 [3.93;11.39]). In males, a higher HOMA‐IR was significantly associated with higher haemoglobin (0.09 [0.03;0.16]). Regarding the longitudinal analysis, similar trends were found, but statistical significance was not reached.ConclusionsBoth longitudinal and cross‐sectional analyses support the hypothesis that insulin resistance is associated with increased red blood cells count and haematocrit in young adults, even within normal ranges of insulin and glucose.
Cortical and Commissural Defects Upon HCF‐1 Loss in Nkx2.1‐Derived Embryonic Neurons and Glia
Authors: Minocha Shilpi , Herr Winship 
Published: June 2019

AbstractFormation of the cerebral cortex and commissures involves a complex developmental process defined by multiple molecular mechanisms governing proliferation of neuronal and glial precursors, neuronal and glial migration, and patterning events. Failure in any of these processes can lead to malformations. Here, we study the role of HCF‐1 in these processes. HCF‐1 is a conserved metazoan transcriptional co‐regulator long implicated in cell proliferation and more recently in human metabolic disorders and mental retardation. Loss of HCF‐1 in a subset of ventral telencephalic Nkx2.1‐positive progenitors leads to reduced numbers of GABAergic interneurons and glia, owing not to decreased proliferation but rather to increased apoptosis before cell migration. The loss of these cells leads to development of severe commissural and cortical defects in early postnatal mouse brains. These defects include mild and severe structural defects of the corpus callosum and anterior commissure, respectively, and increased folding of the cortex resembling polymicrogyria. Hence, in addition to its well‐established role in cell proliferation, HCF‐1 is important for organ development, here the brain.
Plant communities along preferential superficial water flow paths across a floodplain landscape
Authors: Entraigas Ilda , Vercelli Natalia , Fajardo Luisa 
Published: June 2019

AbstractFrom a hydrological perspective, is specially necessary to face the challenge of obtaining a complete spatial arrangement of the drainage network on floodplains with extremely flat relief, impermeable soils and exposed to periodic flooding. Focusing on a sector of the Flooding Pampa in Argentina, our aim was to gain a better understanding of the ways in which vegetation along preferential superficial water flow paths across a floodplain landscape differs from the matrix. We selected three sites along these flow paths, spanning a groundwater salinity gradient. Sampling points were located along transects, transversally arranged to surface and groundwater flows direction. Considering that alternating flooding and drought is an intrinsic characteristic of the region, the drainage network shows expansion and contraction cycles in response to variations in water availability. In this dynamics, preferential superficial water flow paths emerge in the floodplain landscape or disappear. The degree of expression of these paths depends on their location on the topographic gradient, because they tend to lose their degree of channelling as the ground relative heights decrease. Although in the first instance the vegetation matrix seems to be relatively homogeneous, the analysis on a detailed scale allows us to distinguish certain heterogeneity in that pattern. Our analysis shows that there is a downstream variation in the spatial distribution of the vegetation following the topographic and groundwater salinity gradients and that the degree of channelling and soil alkalinity determines the type of plant community to be developed in a certain site of the floodplain landscape.
Numerical simulation of boreholes for gas extraction and effective range of gas extraction in soft coal seams
Authors: Wei Pan , Huang Changwen , Li Xuelong , Peng Shoujian , Lu Yanan 
Published: June 2019

AbstractGas disasters are a major factor influencing safe production in mines: Gas extraction can reduce the gas content in coal seams, providing a guarantee of safer production. The parameters for gas extraction are the primary factors influencing the effectiveness thereof. Aiming at the creep properties of soft coal, a fluid‐solid coupling mathematical model considering creep properties of coal was established based on dynamic evolution equation for permeability considering the effects of matrix shrinkage and effective stress. Additionally, by utilizing COMSOL Multiphysics software, the gas extractions from a single borehole and multiple boreholes were calculated. Moreover, the parameters for gas extraction were optimized and applied and tested in field conditions. The result showed the reduction in gas pressure around the boreholes was larger than that from a single borehole when conducting gas extraction from multiple boreholes. The borehole spacing when extracting gas in coal seams by drilling multiple boreholes should be more than twice that of the effective drainage radius. The optimal borehole spacing ranged from 3.2 to 4.2 m for gas extraction lasting 180 d. Numerical simulation was carried out to ascertain the distribution of stress on coal around a roadway. The result revealed that the damage radius of the roadway was 11.8 m, and a reasonable hole‐sealing depth was 12 m. On condition that the borehole spacing during gas extraction from multiple boreholes was 4 m, the reasonable pre‐extraction time was 180 days taking the gas pressure being reduced to <0.74 MPa as a critical point. Furthermore, the gas content, the amount of extracted gas, etc, in a working face after the parameters for gas extraction were optimized were measured. The result suggested that the effect of gas extraction after optimizing parameters conformed to industry standards.
Simulation of a multistage fractured horizontal well in a tight oil reservoir using an embedded discrete fracture model
Authors: Zhao Yu‐long , Liu Ling‐fu , Zhang Lie-hui , Zhang Xu‐Yang , Li Bo 
Published: June 2019

AbstractAs an unconventional resource, tight oil reservoirs hold abundant geological reserves and great development potential. However, tight oil reservoirs suffer from high heterogeneity and low permeability. To obtain commercial oil and gas flow, multistage hydraulically fractured horizontal well technology is often adopted. In this paper, an embedded discrete fracture model (EDFM) is adopted to study the fractured reservoir. First, the relationship between the EDFM connection list is studied and its coefficient matrix of the equation system is solved. EDFM connection list is a method to record the connections between the grids. Thereafter, the reasons for the sparsity of the coefficient matrix and the symmetry of the locations of nonzero elements in the matrix are explained, and a simple method to establish and assemble the coefficient matrix is proposed. Using this method, a simulator for tight oil reservoir with EDFM is developed. By comparing the simulation results of the self‐programming simulator with the commercial software SAPHIR, the usefulness of the simulator is verified. Finally, several simulations and sensitivity analysis are performed to determine the key factors affecting production. Modeling studies show the influence of fractures, the horizontal well, and stress sensitivity, providing very useful information for the design of hydraulic fracturing and production development programs.
Pharmacological effects of different ginger juices on the concurrent symptoms in animal models of functional dyspepsia: A comparative study
Authors: Zhong Ling‐yun , Tong Heng‐li , Zhu Jing , Lv Mu 
Published: June 2019

AbstractObjectivePatients with gastrointestinal disorders commonly suffer from poor treatment outcomes and adverse effects of traditional pharmacological therapy. Herbal medicine is a favorable alternative due to the low risk of side effects. This study was performed to explore the antiemetic effects and the improvement effect on gastrointestinal function of components of three ginger juice excipients.MethodsThe compositions were analyzed by liquid chromatograph mass spectrometer (LC‐MS), especially the gingerols of dried ginger juice (DGJ), fresh ginger juice (FGJ), and fresh ginger boiled juice (FGBJ). Furthermore, the respective gastrointestinal effects on rat models with functional dyspepsia (FD) were compared.ResultsThe 6‐keto‐PGF1α levels in the serum of the treated groups were significantly reduced (p < 0.05), as compared with the control group. Compared with the cisplatin group, there was an apparent reduction in kaolin intake for DGJ, FGJ, and FGBJ (p < 0.01; p < 0.01; p < 0.05). The intestinal propulsive rate of the rats in the treated group was significantly higher than that in the control group (p < 0.05). Ginger juices significantly improved gastrointestinal function in rats. Eight common components were found in DGJ, FGJ, and FGBJ, among which 6‐paradol, 10‐gingerol, and 12‐shogaol led to inhibited gastric mucosal damage function effect according to the Pearson correlation analysis. Only 6‐shogaol was found to have a positive correlation with gastrointestinal function effect through Pearson correlation analysis.ConclusionGinger juice should be recommended for the medicinal materials used in the treatment of concurrent symptoms of FD.
Comparison of the diagnostic accuracy of International Ovarian Tumor Analysis simple rules and the risk of malignancy index to discriminate between benign and malignant adnexal masses
Authors: Auekitrungrueng Rapeepat , Tinnangwattana Dangcheewan , Tantipalakorn Charuwan , Charoenratana Cholaros , Lerthiranwong Thitikarn , Wanapirak Chanane , Tongsong Theera 
Published: June 2019

AbstractObjectiveTo compare the diagnostic accuracy of International Ovarian Tumor Analysis (IOTA) simple rules and risk of malignancy index (RMI 1/RMI 2) scoring to discriminate between benign and malignant adnexal masses.MethodsSecondary analysis of a cohort of patients scheduled for surgery for adnexal masses in a tertiary center between April 2010 and March 2018. Ultrasound examinations were performed by general gynecologists within 24 hours prior to surgery to evaluate sonographic features. Demographic data and preoperative CA 125 levels were recorded. IOTA rules and RMI scoring were applied to predict malignancy and prospectively recorded. Final diagnosis was based on pathological or intraoperative diagnosis.ResultsA total of 479 masses met the inclusion criteria and were retrieved from the database: 334 (69.7%) benign and 145 (30.3%) malignant. IOTA rules could be applied to 392 (81.8%) masses and were inconclusive in 87 (18.2%). Sensitivity and specificity of IOTA rules (83.8% and 92.0%, respectively) were significantly higher than RMI 1 (77.2% and 86.8%, respectively) and RMI 2 (82.1% and 82.6%, respectively).ConclusionIOTA simple rules had higher diagnostic accuracy compared with RMI to discriminate between benign and malignant adnexal masses; however, nearly 20% of IOTA results were inconclusive and needed expert consultation.
Thermal isomerization of ruthenium hydride compounds containing asymmetric bidentate pyrrole‐imine ligands
Authors: Lai Hsuan‐Ting , Chen Kun‐Hao , Li Yong‐Jie , Wu Cheng‐Hsien , Hu Ching‐Han , Lin Chia‐Her , Huang Jui‐Hsien 
Published: June 2019

AbstractA series of ruthenium hydride compounds containing substituted bidentate pyrrole‐imine ligands were synthesized and characterized. Reacting RuHCl(CO)(PPh3)3 with one equivalent of [C4H3NH(2‐CH=NR)] in ethanol in the presence of KOH gave compounds {RuH(CO)(PPh3)2[C4H3N(2‐CH=NR)]} where trans‐Py‐Ru‐H 1, R = CH2CH2C6H9; cis‐Py‐Ru‐H 2, R = Ph‐2‐Me; and cis‐Py‐Ru‐H 3, R = C6H11. Heating trans‐Py‐Ru‐H 1 in toluene at 70°C for 12 hr resulted a thermal conversion of the trans‐Py‐Ru‐H 1 into its cis form, {RuH(CO)(PPh3)2[C4H3N(2‐CH=NCH2CH2C6H9)]} (cis‐Py‐Ru‐H 1) in very high yield. The 1H NMR spectra of trans‐Py‐Ru‐H 1, cis‐Py‐Ru‐H 2, cis‐Py‐Ru‐H 3, and cis‐Py‐Ru‐H 1 all show a typical triplet at ca. δ–11 for the hydride. The trans and cis form indicate the relative positions of pyrrole ring and hydride. The geometries of trans‐Py‐Ru‐H 1, cis‐Py‐Ru‐H 1, and cis‐Py‐Ru‐H 3 are relatively similar showing typical octahedral geometries with two PPh3 fragments arranged in trans positions.
Downregulation of JKAP is correlated with elevated disease risk, advanced disease severity, higher inflammation, and poor survival in sepsis
Authors: Zhao Min , Huang Xing 
Published: June 2019

AbstractObjectiveThis study aimed to explore the association of JKAP with sepsis risk and investigate its correlation with disease severity, inflammatory cytokines, and survival in sepsis patients.MethodsA hundred and one sepsis patients along with 100 healthy controls were enrolled, and their blood serum samples were collected for JKAP and inflammatory cytokines measurement by enzyme‐linked immunoassay. The difference in serum JKAP between sepsis patients and healthy controls was determined. Among sepsis patients, the correlation of JKAP with disease severity, laboratory indexes, inflammatory cytokines, 28‐day mortality, and accumulating survival was analyzed.ResultsJNK pathway–associated phosphatase level was decreased in sepsis patients compared with healthy controls and presented with good value in predicting decreased sepsis risk (AUC = 0.896 [95% CI: 0.851‐0.941]). And its low expression was associated with advanced disease severity (APACHE II score and SOFA score) and systemic inflammation (CRP, PCT, TNF‐α, IL‐1β, IL‐6, and IL‐17) in sepsis patients. Additionally, JKAP level was decreased in deaths compared with survivors and had good value in distinguishing deaths from survivors (AUC = 0.742 [95% CI: 0.636‐0.849]). Further, Kaplan‐Meier curve analysis disclosed that JKAP high expression predicted more prolonged accumulating survival in sepsis patients.ConclusionJNK pathway–associated phosphatase is of good value in predicting lower sepsis risk, and its downregulation correlates with advanced disease severity, higher level of systemic inflammation, and poor survival in sepsis patients.
MiR‐127 attenuates adipogenesis by targeting MAPK4 and HOXC6 in porcine adipocytes
Authors: Gao Yun , Wang Yingqian , Chen Xiaochang , Peng Ying , Chen Fenfen , He Yulin , Pang Weijun , Yang Gongshe , Yu Taiyong 
Published: June 2019

AbstractMicroRNAs (miRNAs) have critical roles during adipogenesis; however, their precise functions are not completely understood. Porcine miRNA expression profiles show that miR‐127 is dramatically downregulated with age in adipose tissue. We aimed to identify the precise functions and mechanisms of miR‐127 in proliferation and adipogenesis. Preadipocytes were cultured under conditions to induce proliferation or differentiation and the effect of miR‐127 overexpression on these processes, and the associated bioinformatically predicted target genes, were assessed using luciferase assays, quantitative real‐time PCR, western blot analysis, and cell staining techniques. miR‐127 increased proliferation by promoting cell cycling, whereas it suppressed differentiation, which was accompanied by reduced lipid accumulation. miR‐127 targeted mitogen‐activated protein kinase 4 and homeobox C6 (HOXC6) to activate preadipocyte proliferation. During differentiation, miR‐127 targeted HOXC6 to attenuate adipogenesis. These findings identify miR‐127 as an inhibitor of porcine adipogenesis, which may inform future strategies to reduce porcine fat deposition and treat human obesity.
Autophagy induces eosinophil extracellular traps formation and allergic airway inflammation in a murine asthma model
Authors: Silveira Josiane Silva , Antunes Géssica Luana , Kaiber Daniela Benvenutti , da Costa Mariana Severo , Ferreira Fernanda Silva , Marques Eduardo Peil , Schmitz Felipe , Gassen Rodrigo Benedetti , Breda Ricardo Vaz , Wyse Angela T. S. , Stein Renato Tetelbom , Pitrez Paulo Márcio , da Cunha Aline Andrea 
Published: June 2019

AbstractStudies have shown autophagy participation in the immunopathology of inflammatory diseases. However, autophagy role in asthma and in eosinophil extracellular traps (EETs) release is poorly understood. Here, we attempted to investigate the autophagy involvement in EETs release and in lung inflammation in an experimental asthma model. Mice were sensitized with ovalbumin (OVA), followed by OVA challenge. Before the challenge with OVA, mice were treated with an autophagy inhibitor, 3‐methyladenine (3‐MA). We showed that 3‐MA treatment decreases the number of eosinophils, eosinophil peroxidase (EPO) activity, goblet cells hyperplasia, proinflammatory cytokines, and nuclear factor kappa B (NFκB) p65 immunocontent in the lung. Moreover, 3‐MA was able to improve oxidative stress, mitochondrial energy metabolism, and Na+, K+‐ATPase activity. We demonstrated that treatment with autophagy inhibitor 3‐MA reduced EETs formation in the airway. On the basis of our results, 3‐MA treatment can be an interesting alternative for reducing lung inflammation, oxidative stress, mitochondrial damage, and EETs formation in asthma.
Taxonomic study of Triblemma by using light and scanning electron microscopy
Authors: Zheng Ling , Han Jianming , Wang Mali 
Published: June 2019

AbstractTriblemma Ching is a genus proposed by Ching Ren‐Chang in 1978, and it is composed of two species, Triblemma lancea (Thunb.) Ching and Triblemma zeylanica (Hook.) Ching. There has been much debate on the systematic position of Triblemma, and this genus has always been included in Diplazium. Here, we have described new features of tracheary elements, epidermis, spore, scale, and rachis of Triblemma revealed using light and scanning electron microscopy and proposed that Triblemma is closely related to Athyriopsis, which conflicts with the traditional viewpoint.