Acute Lipodermatosclerosis-Like Eruption and Deep Vein Thrombosis Due to Gemcitabine Use
Authors: Yıldız Yasin 
Published: December 2024

Abstract:
Introduction: Gemcitabine is a chemotherapy agent commonly used in the treatment of various solid tumors. Its cutaneous side effects are less well-documented, and its venous thromboembolic side effects are controversial. Here, we aim to present a case diagnosed with an acute lipodermatosclerosis-like eruption and deep vein thrombosis following gemcitabine treatment.
Case Report: A 66-year-old male patient presented with new-onset eruptions and swelling in the right lower extremity, four days after the first dose of gemcitabine treatment for metastatic lung cancer. On examination, there were purple-red plaques and petechiae on the right lower extremity and 2+ edema was detected.. By superficial ultrasound (USG) diagnosis of DVT was made. The patient was discharged with recommendations for subcutaneous enoxaparin, leg elevation, and follow-up in the outpatient clinic on the fifth day with continued antibiotic therapy.
Conslusion: Acute lipodermatosclerosis-like rash, a rare but potential cutaneous side effect in patients receiving gemcitabine treatment, should be well recognized and managed. This ensures the continuity or need for revision of treatment. Additionally, vigilance for possible venous thromboembolic events should be maintained in patients receiving gemcitabine treatment, and the possibility of concurrent occurrences with cutaneous side effects should not be overlooked.
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