bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detecting lenticulostriate artery lesions in patients with acute ischemic stroke using high-resolution MRA at 7 T
Authors: Miyazawa Haruna , Natori Tatsunori , Kameda Hiroyuki , Sasaki Makoto , Ohba Hideki , Narumi Shinsuke , Ito Kohei , Sato Mitsunobu , Suzuki Takafumi , Tsuda Keisuke , Yoshioka Kunihiro , Terayama Yasuo 
Published: October 2018

Background Recent advances in high-resolution (HR) magnetic resonance angiography (MRA) using ultrahigh-field systems enable direct visualization of the lenticulostriate arteries (LSAs), which had been hardly achieved by conventional MRA. Hence, by using HR-MRA at 7 T, we attempted to assess occlusive changes in the LSAs in patients with LSA territorial infarcts. Methods We prospectively examined 34 consecutive patients with acute ischemic stroke in the LSA territory using a 7 T scanner. We measured the lengths of the relevant LSAs on HR-MRA and the diameters/volume of the infarcts and compared these between the patients with/without occlusive changes in the LSAs. Results On HR-MRA, occlusion of the LSAs was observed in 19 (59%) of 32 patients who were eligible for the analyses. The curved/straight lengths of the LSAs in the patients with LSA occlusion (23.1–31.1/17.8–24.3 mm) were significantly shorter than in those without apparent LSA occlusion (25.8–39.5/24.0–30.4 mm) ( P = 0.027/0.003). The anteroposterior/superoinferior diameters of the infarcts were significantly larger in the occluded-LSA group (14.5–21.4/14.9–22.2 mm) than in the intact-LSA group (10.9–16.8/10.8–16.2 mm) ( P = 0.041/0.011). In addition, the curved lengths of the relevant LSAs showed significant correlations with the superoinferior diameters of the infarcts ( r = 0.38, P = 0.034). Conclusion Occlusive changes in the LSAs were frequently found in patients with acute ischemic stroke within the LSA territory when using HR-MRA at 7 T and were substantially related to superoinferior extension of the infarcts.
Effects of Concomitant Decompression Adjacent to a Posterior Lumbar Interbody Fusion Segment on Clinical and Radiologic Outcomes: Comparative Analysis 5 Years After Surgery
Authors: Matsumoto Tomiya , Okuda Shinya , Nagamoto Yukitaka , Sugiura Tsuyoshi , Takahashi Yoshifumi , Iwasaki Motoki 
Published: October 2018

Study Design: Retrospective cohort study. Objective: To examine the effects of concomitant decompression adjacent to the posterior lumbar interbody fusion (PLIF) segment on the clinical and radiological outcomes 5 years after surgery. Methods: Forty-five consecutive patients who had undergone L3/4 decompression with L4/5 PLIF for multilevel stenosis with degenerative spondylolisthesis (DS), and were followed for 5 years, were enrolled (group D). As a control group, 45 age-, sex- and preoperative disc height at L3/4–matched patients who had undergone L4/5 PLIF alone for L4/5DS were randomly selected (group A). Disc height, vertebral slippage, range of motion, posterior opening angle, segmental lordotic angle, presence of the intradiscal vacuum phenomenon (IVP) at the L3/4 level were measured on radiographs. Japanese Orthopaedic Association (JOA) score and the requirement for additional L3/4 surgery were evaluated. Results: In terms of pre-/postoperative radiographic changes between the groups, significant differences were detected regarding disc height narrowing of ≥3 mm (group D 31%, group A 9%) and IVP (group D 33%, group A 11%). There were no significant differences in other radiological parameters. The recovery rate of the JOA score (group D 58%, group A 61%) and reoperation rate (group D 2.2%, group A 6.7%) were not significantly different between the groups. Conclusion: Concomitant decompression adjacent to the PLIF segment accelerated adjacent disc degeneration compared to PLIF alone, but it did not predispose to the development of instability 5 years after surgery. Moreover, the JOA score and reoperation rate were not significantly different between groups D and A.
Does short-term weekly teriparatide improve healing in unstable intertrochanteric fractures?
Authors: Kim Seung-Ju , Park Hyun-Soo , Lee Dong-Woo , Lee Jae-Won 
Published: October 2018

Slow recovery after hip fracture has been associated with negative consequences. Thus, there is medical need to improve healing and functional recovery after intertrochanteric fracture. The aim of this study was to measure whether short-term teriparatide would improve healing in intertrochanteric fractures after internal fixation as measured by (1) clinical scores, (2) radiographic fracture healing, and (3) complication rates. We retrospectively reviewed 96 patients (average age, 82 years) who underwent closed reduction and internal fixation with proximal femoral nail (PFN) for unstable intertrochanteric fractures between 2014 and 2016. Of the 96 patients, 56 patients were treated with a PFN alone (group 1). These patients were compared with 46 patients for whom the same device was used and a weekly subcutaneous injection of PTH 1-34 (teriparatide) was prescribed postoperatively (group 2). Questionnaire surveys or telephone interviews were conducted, and patients completed a self-report Harris hip score and visual analog scale scores. The radiological time to fracture healing was assessed as the primary end point. Postoperative complication rates were compared. Functional outcomes at 6 months after surgery were similar in both groups. There were no differences between groups in the proportion of patients achieving radiographic fracture healing. The frequency of patients reporting adverse events was 20% (10 of 50) in group 1 versus 17% (8 of 46) in group 2 ( p = 0.744). Short-term teriparatide did not improve radiographic signs of fracture healing of an intertrochanteric fracture and reduce the incidence of complications. The effect of teriparatide on fracture healing remains uncertain. Further multicenter prospective studies are needed to demonstrate objective long-term results of parathyroid hormone therapy in patient with hip fracture. Level of Evidence: Level IV, therapeutic study.
Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL
Authors: Siekmann Ina-Katrin , Dierck Kevin , Prall Sebastian , Klokow Marianne , Strauss Julia , Buhs Sophia , Wrzeszcz Antonina , Bockmayr Michael , Beck Florian , Trochimiuk Magdalena , Gottschling Kristina , Martens Victoria , Khosh-Naucke Melissa , Gerull Helwe , Müller Jürgen , Behrmann Lena , Blohm Martin , Zahedi René P. , Jeremias Irmela , Sickmann Albert , Nollau Peter , Horstmann Martin A. 
Published: October 2018

Abstract
Receptor tyrosine kinase (RTK)-dependent signaling has been implicated in the pathogenesis of acute lymphoblastic leukemia (ALL) of childhood. However, the RTK-dependent signaling state and its interpretation with regard to biological behavior are often elusive. To decipher signaling circuits that link RTK activity with biological output in vivo, we established patient-derived xenograft ALL (PDX-ALL) models with dependencies on fms-like tyrosine kinase 3 (FLT3) and platelet-derived growth factor receptor β (PDGFRB), which were interrogated by phosphoproteomics using iTRAQ mass spectrometry. Signaling circuits were determined by receptor type and cellular context with few generic features, among which we identified group I p21-activated kinases (PAKs) as potential therapeutic targets. Growth factor stimulation markedly increased catalytic activities of PAK1 and PAK2. RNA interference (RNAi)-mediated or pharmacological inhibition of PAKs using allosteric or adenosine triphosphate (ATP)-competitive compounds attenuated cell growth and increased apoptosis in vitro. Notably, PAK1- or PAK2-directed RNAi enhanced the antiproliferative effects of the type III RTK and protein kinase C inhibitor midostaurin. Treatment of FLT3- or PDGFRB-dependent ALLs with ATP-competitive PAK inhibitors markedly decreased catalytic activities of both PAK isoforms. In FLT3-driven ALL, this effect was augmented by coadministration of midostaurin resulting in synergistic effects on growth inhibition and apoptosis. Finally, combined treatment of FLT3D835H PDX-ALL with the ATP-competitive group I PAK inhibitor FRAX486 and midostaurin in vivo significantly prolonged leukemia progression-free survival compared with midostaurin monotherapy or control. Our study establishes PAKs as potential downstream targets in RTK-dependent ALL of childhood, the inhibition of which might help prevent the selection or acquisition of resistance mutations toward tyrosine kinase inhibitors.
Passive seismic tomography using recorded microseismicity: Application to mining-induced seismicity
Authors: Barthwal Himanshu , van der Baan Mirko 
Published: October 2018

Microseismicity is recorded during an underground mine development by a network of seven boreholes. After an initial preprocessing, 488 events are identified with a minimum of 12 P-wave arrival-time picks per event. We have developed a three-step approach for P-wave passive seismic tomography: (1) a probabilistic grid search algorithm for locating the events, (2) joint inversion for a 1D velocity model and event locations using absolute arrival times, and (3) double-difference tomography using reliable differential arrival times obtained from waveform crosscorrelation. The originally diffusive microseismic-event cloud tightens after tomography between depths of 0.45 and 0.5 km toward the center of the tunnel network. The geometry of the event clusters suggests occurrence on a planar geologic fault. The best-fitting plane has a strike of 164.7° north and dip angle of 55.0° toward the west. The study region has known faults striking in the north-northwest–south-southeast direction with a dip angle of 60°, but the relocated event clusters do not fall along any mapped fault. Based on the cluster geometry and the waveform similarity, we hypothesize that the microseismic events occur due to slips along an unmapped fault facilitated by the mining activity. The 3D velocity model we obtained from double-difference tomography indicates lateral velocity contrasts between depths of 0.4 and 0.5 km. We interpret the lateral velocity contrasts in terms of the altered rock types due to ore deposition. The known geotechnical zones in the mine indicate a good correlation with the inverted velocities. Thus, we conclude that passive seismic tomography using microseismic data could provide information beyond the excavation damaged zones and can act as an effective tool to complement geotechnical evaluations.
Optical Approaches for Interrogating Neural Circuits Controlling Hormone Secretion
Authors: Han Su Young , Clarkson Jenny , Piet Richard , Herbison Allan E 
Published: October 2018

Abstract
Developments in optical imaging and optogenetics are transforming the functional investigation of neuronal networks throughout the brain. Recent studies in the neuroendocrine field have used genetic mouse models combined with a variety of light-activated optical tools as well as GCaMP calcium imaging to interrogate the neural circuitry controlling hormone secretion. The present review highlights the benefits and caveats of these approaches for undertaking both acute brain slice and functional studies in vivo. We focus on the use of channelrhodopsin and the inhibitory optogenetic tools, archaerhodopsin and halorhodopsin, in addition to GCaMP imaging of individual cells in vitro and neural populations in vivo using fiber photometry. We also address issues around the use of genetic vs viral delivery of encoded proteins to specific Cre-expressing cell populations, their quantification, and the use of conscious vs anesthetized animal models. To date, optogenetics and GCaMP imaging have proven useful in dissecting functional circuitry within the brain and are likely to become essential investigative tools for deciphering the different neural networks controlling hormone secretion.
En Homenaje a Latinx Studies
Authors: Brickhouse Anna 
Published: October 2018

Abstract
This short essay was written in the days after white supremacists and neo-Nazis invaded the campus of the University of Virginia and downtown Charlottesville, many of them heavily armed and dressed for combat. After offering a brief reflection on how Latino/a/x studies shaped her scholarly trajectory as someone not trained in this field as a graduate student, the author asks how the field can help reimagine this particular political moment. The essay reads Junot Díaz’s Brief Wondrous Life of Oscar Wao forward in time—as an anticipatory history illuminating the last US presidential election.
Forging a Borderlands Baroness
Authors: Huizar-Hernández Anita 
Published: October 2018

AbstractIn 1895 a woman from California named Sofia Peralta-Reavis leaped into the national spotlight when her husband, James Reavis, sued the federal government for confirmation of her title to the Peralta Land Grant, an enormous Spanish land grant in the territories of Arizona and New Mexico. At the highly publicized trial that followed, it came to light that the evidence Reavis had presented to the court to prove the existence of the Peralta Land Grant and his wife’s title to it was forged. This essay uses the trial transcript to recover the woman at the center of the scandal, arguing that Sofia Peralta-Reavis’s fraudulent embodiment of a wealthy Spanish baroness unmasks the fluidity and fragility of racial categories, gender, and authenticity in the late nineteenth-century borderlands.
Latin Place Making in the Late Nineteenth and Early Twentieth Centuries
Authors: Dworkin y Méndez Kenya C. 
Published: October 2018

Abstract
Starting in the mid-1880s and becoming fully effective by the 1930s, the “curriculum of culture” that Tampa’s Latin immigrant, cigar-making enclaves experienced circulated in the spaces they and others occupied regularly—the cigar factory, mutual aid society, the coffeehouse, and the theater (also homes and the union hall). These Cuban (and Spanish and Italian) cultural and social values were passed on from one generation to the next within the community, and even to non-Cubans, via reverse assimilation. The outcome was an ethnic American social identity whose impact thoroughly transformed living and working spaces in a segregated, Jim Crow space and fundamentally reshaped its landscape, foodways, and identity. The brand of “Americanism” that Tampa’s Latin community practiced did not typically display the competitive individualism often associated with traditional Americanism, instead emphasizing living as a community and fostering cooperation and affiliations among numerous sociocultural groups.
Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA
Authors: Loro Emanuele , Bisetto Sara , Khurana Tejvir S. 
Published: October 2018

ABSTRACT
The pro-inflammatory cytokine interleukin-15 (IL15) and its receptor α (IL15RA) participate in the regulation of musculoskeletal function and metabolism. Deletion of the Il15ra gene in mice increases spontaneous activity, improves fatigue resistance in the glycolytic extensor digitorum longus (EDL) and protects from diet-induced obesity. In humans, IL15RA single-nucleotide polymorphisms (SNPs) have been linked to muscle strength, metabolism and performance in elite endurance athletes. Taken together, these features suggest a possible role for IL15RA in muscle mitochondrial structure and function. Here, we have investigated the consequences of loss of IL15RA on skeletal muscle fiber-type properties and mitochondrial ultrastructure. Immunostaining of the EDL for myosin heavy chain (MyHC) isoforms revealed no significant changes in fiber type. Electron microscopy (EM) analysis of the EDL indicated an overall higher mitochondria content, and increased cristae density in subsarcolemmal and A-band mitochondrial subpopulations. The higher cristae density in Il15ra−/− mitochondria was associated with higher OPA1 and cardiolipin levels. Overall, these data extend our understanding of the role of IL15RA signaling in muscle oxidative metabolism and adaptation to exercise.
TM9SF4 levels determine sorting of transmembrane domains in the early secretory pathway
Authors: Vernay Alexandre , Lamrabet Otmane , Perrin Jackie , Cosson Pierre 
Published: October 2018

ABSTRACT
Previous studies have shown that TM9SF4 interacts with glycine-rich transmembrane domains (TMDs) and promotes their surface localization, presumably by escorting them along the secretory pathway. Here, we delineated the role of TM9 proteins in the sorting of TMDs. Our results indicate that TM9SF4 interacts with and sorts a variety of TMDs. In human embryonic kidney (HEK) cells, a TMD carrying a positively charged residue (T-R1) or a negatively charged residue (T-D1) was localized to the endoplasmic reticulum (ER), but partially relocated to the Golgi complex upon overexpression of TM9SF4. These results show that TM9SF4 controls the sorting of TMDs at the ER-Golgi interface. Remarkably, sorting of T-R1 in HCT116 cells was different from that in HEK cells: in HCT116 cells, a substantial fraction of T-R1 was localized to the Golgi complex, and it was relocated to the ER by genetic ablation of TM9SF4. This observation indicates that TM9SF4 sorting activity differs in HEK and HCT116 cells, resulting in different sorting of TMDs in these two cell types. Although TM9SF1 associated with several TMDs, it did not visibly alter their intracellular transport in the secretory pathway and may function in other intracellular transport pathways.
Multilevel analysis concerning the relationship between social vulnerability and the healthy use of leisure time in children and adolescents in Argentina: A national population-based study
Authors: Moyano Daniela , Forclaz Zarina , Chaparro Raúl M. , Hernández-Vásquez Akram , Perovic Nilda R. 
Published: October 2018

Background: Leisure time is a human right and has to be considered part of any health promotion initiative aimed at children and adolescents. The objective of this study was to analyze the relationship between social vulnerability and the healthy use of leisure time in children and adolescents in urban contexts of Argentina, in 2012. Methods: A cross-sectional and analytical study using data from the Module on Activities of Girls, Boys and Adolescents of the Annual Urban Household Survey was carried out. In this survey, a self-administered instrument was applied to 25,915 individuals aged from 5 to 17. A Social Vulnerability Index (SVI) was developed. Association was estimated by multilevel logistic regression. Results: Children and adolescents use most of their leisure time to carry out school activities (90.1%) with art activities having the lowest percentage (21.8%). In the multilevel models on the relationship between a high SVI and non-performance of socialization activities, the OR was 1.99 (p = 0.002, 95% CI: 1.28-3.12). The association between high SVI and non-use of ICT gave an OR of 14.17 (p ≤ 0.001, 95% CI: 5.13-39.17), and between high SVI and non-use of internet, an OR of 21.89 (p ≤ 0.001, 95% CI: 7.50-63.88). Conclusions: A high SVI negatively impacts on some healthy activities of leisure time for children and adolescents in Argentina. The SVI could be a useful tool to guide health promotion initiatives in this population.
Scattered Storage: How to Distribute Stock Keeping Units All Around a Mixed-Shelves Warehouse
Authors: Weidinger Felix , Boysen Nils 
Published: October 2018

Scattered storage is a storage assignment strategy where single items are isolated and distributed all around the shelves of a warehouse. This way, the probability of always having some items per stock-keeping units close-by is increased, which is intended to reduce the unproductive walking time during order picking. Scattered storage is especially suited if each order line demands just a few items, so that it is mainly applied by business-to-consumer online retailers. This paper formulates a storage assignment problem supporting the scattered storage strategy. We provide and test suited solution procedures and investigate important managerial aspects, such as the frequency with which refilling the shelves should be executed. The online appendix is available at https://doi.org/10.1287/trsc.2017.0779 .
Intertrigo: a guide to diagnosis, treatment and prevention
Authors: Nazarko Linda 
Published: October 2018

The UK population is ageing, becoming more overweight. The rates of type 2 diabetes mellitus have risen by 250% from 1999 to 2016 and there are now around 3.7 million people in the UK with diabetes ( Diabetes UK, 2017 ). Older skin is more vulnerable to damage and infection and healing is impaired. Obesity increases the risk of skin infections and people with diabetes are at greater risk of infection and impaired healing than people who do not have diabetes. This article examines the identification, treatment and prevention of intertrigo in an older woman who is obese and has diabetes.
Social Studies Teachers’ Perspectives on the Advantages and Challenges of Interactive Whiteboard Application in Oman
Authors: Al-Rabaani Ahmed Hamad 
Published: October 2018

<p style="text-align:justify">The study investigates the views of social studies teachers (SSTs) about the advantages and challenges of interactive whiteboard application in social studies lessons. Data was gathered using a questionnaire consisting of 58 items. The sample comprised 483 male and female SSTs from different governorates of Oman who were provided with three training programs about using Interactive Whiteboard (IWB). Data were analyzed by using: Means, T-test and One Way ANOVA. The results indicated that they considered its effect to be significant in supporting students’ learning process by enhancing the quality of learning environment, excitement of use and importance of use in social studies lessons. It also showed that they used it widely in their lessons but they experienced moderate challenges, including related to technical support and the availability of IWB in all classes. The results also indicated that teachers’ gender and experience influenced their views. The study recommends the provision of more technical support to teachers.</p>
AVALIAÇÃO DA INTERFERÊNCIA IN VITRO DO EXTRATO AQUOSO DE LIPPIA SIDOIDES CHAM. NA DETERMINAÇÃO DA GLICEMIA PLASMÁTICA
Authors: Gonçalves Dos Santos Hevyla , David Cabral Bezerra Leonardo , De Aquino Saraiva Rogério , De Oliveira Alencar Gustavo , Nogueira Holanda Veras Helenicy 
Published: October 2018

O uso de plantas para fins medicinais é uma prática muito antiga nas diferentes culturas ao redor do mundo. Contudo, o consumo de plantas medicinais pode interferir em processos metabólicos (in vivo) ou em métodos analíticos (in vitro), produzindo resultados laboratoriais que podem sugerir ou mascarar processos patológicos. Lippia sidoides, conhecida popularmente como alecrim-pimenta, é uma planta com propriedades antisséptica, antimicrobiana, anti-inflamatória e larvicida e é encontrada no Nordeste brasileiro e na região semiárida do norte de Minas Gerais. Assim, esta pesquisa teve como objetivo investigar se os extratos aquosos das folhas de L. sidoides por infusão (EALSI) e decocção (EALSD) são capazes de interferir no ensaio enzimático para quantificação de glicose sanguínea. Alíquotas dos extratos (0,1; 1 e 10 mg/dL) foram adicionadas às amostras biológicas (pool de plasma fluoretado) e após 1 hora, a glicose foi quantificada por meio de ensaio colorimétrico enzimático (Reação de Trinder). A prospecção fitoquímica foi capaz de identificar a presença de alcaloides, flavonoides, flavonóis, flavanonas, xantonas, taninos, esteroides e triterpenoides em ambos os extratos. Quanto à possível interferência que esses extratos poderiam causar na determinação da glicemia, apenas na concentração de 10 mg/dL houve um aumento significativo no nível de glicose para 321,5±10,0 mg/dL (EALSI) e 304,3±9,3 mg/dL (EALSD) quando comparados ao controle (85,4±3,6 mg/dL, ANOVA de uma via e teste de Tukey, p<0,05). Por fim, são necessários mais estudos a fim de elucidar qual ou quais substâncias são responsáveis por essa interferência e o mecanismo de ação frente a testes bioquímicos realizados rotineiramente em um laboratório clínico.