bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Novel Direct AR Target Gene Annexin A2 Mediates Androgen-Induced Cellular Senescence in Prostate Cancer Cells
Authors: Mirzakhani Kimia , Heidari Horestani Mehdi , Kallenbach Julia , Atri Roozbahani Golnaz , Baniahmad Aria 
Published: November 2024

AbstractClinical trials for prostate cancer (PCa) patients have implemented the bipolar androgen therapy (BAT) that includes the treatment with supraphysiological androgen level (SAL). SAL treatment induces cellular senescence in tumor samples of PCa patients and in various PCa cell lines, including castration-resistant PCa (CRPC), and is associated with enhanced phospho-AKT levels. Using an AKT inhibitor (AKTi), the SAL-mediated cell senescence is inhibited. Here, we show by RNA-seq analyses of two human PCa cell lines, that annexin A2 (ANXA2) expression is induced by SAL and repressed by co-treatment with AKTi. Higher ANXA2 expression is associated with better survival of PCa patients and suggests that ANXA2 is part of SAL-mediated tumor suppressive activity. ChIP-seq revealed that AR is recruited to the intronic regions of ANXA2 gene suggesting that ANXA2 is a novel direct AR target gene. Knockdown of ANXA2 shows that SAL-induced cellular senescence is mediated by ANXA2 and enhances the levels of phospho-AKT indicating an interaction between the AR, ANXA2 and AKT. Notably, we found that the level of heat shock protein HSP27, known to interact with ANXA2, is associated with cellular senescence. HSP27 level is induced by SAL but the induction is blunted by knockdown of ANXA2 suggesting a novel ANXA2-HSP27 pathway in PCa. This was confirmed using an HSP27 inhibitor that reduced the SAL-induced cellular senescence levels suggesting that ANXA2 upregulates HSP27 to mediate AR-signaling in SAL-induced cellular senescence. Thus, the data indicate ANXA2-HSP27 cross-talk as novel factors in the signaling by the AR-AKT pathway to mediate cellular senescence.
Effect of burst spikes on linear and nonlinear signal transmission in spiking neurons
Authors: Schlungbaum Maria , Barayeu Alexandra , Grewe Jan , Benda Jan , Lindner Benjamin 
Published: November 2024

Abstract
We study the impact of bursts on spike statistics and neural signal transmission. We propose a stochastic burst algorithm that is applied to a burst-free spike train and adds a random number of temporally-jittered burst spikes to each spike. This simple algorithm ignores any possible stimulus-dependence of bursting but allows to relate spectra and signal-transmission characteristics of burst-free and burst-endowed spike trains. By averaging over the various statistical ensembles, we find a frequency-dependent factor connecting the linear and also the second-order susceptibility of the spike trains with and without bursts. The relation between spectra is more complicated: besides a frequency-dependent multiplicative factor it also involves an additional frequency-dependent offset. We confirm these relations for the (burst-free) spike trains of a stochastic integrate-and-fire neuron and identify frequency ranges in which the transmission is boosted or diminished by bursting. We then consider bursty spike trains of electroreceptor afferents of weakly electric fish and approach the role of burst spikes as follows. We compare the spectral statistics of the bursty spike train to (i) that of a spike train with burst spikes removed and to (ii) that of the spike train in (i) endowed by bursts according to our algorithm. Significant spectral features are explained by our signal-independent burst algorithm, e.g. the burst-induced boosting of the nonlinear response. A difference is seen in the information transfer for the original bursty spike train and our burst-endowed spike train. Our algorithm is thus helpful to identify different effects of bursting.
A consolidated framework for implementation research (CFIR) guided exploration of key informant perspectives on establishing a pharmacist-led anticoagulation service in primary care: a qualitative study
Authors: Alshihab Safaa , Ibrahim Mohamed Izham Mohamed , Al-Zaidan Manal , Hadi Muhammad Abdul 
Published: November 2024

Abstract
Background
Globally, pharmacist-led anticoagulation services have improved patient outcomes in secondary and tertiary care settings. However, there is a paucity of literature about establishing such services within primary care settings.

Aim
This study explored key informants' perceptions regarding the systemic and procedural factors influencing development and implementation of a pharmacist-led anticoagulation service in a primary care setting.

Method
A descriptive qualitative study was conducted at Qatar's largest primary healthcare institution, the Primary Health Care Corporation (PHCC). Selected key informants, including healthcare center managers, pharmacy leads, physician leads and primary care physicians with cardiology privileges, were purposively recruited. Semi-structured interviews were guided by the Consolidated Framework for Implementation Research (CFIR) and analyzed using framework analysis.

Results
Elven key informants were interviewed. The participants expressed confidence in the feasibility and effectiveness of implementing anticoagulation service in primary care to address patients’ needs. Key factors (mapped to CFIR domains) included ensuring pharmacist competency (Characteristics of Individuals), establishing effective internal and external communication (Inner and Outer Setting), and addressing staffing shortages (Inner Setting). Participants also emphasized on developing standardized operational protocols and training programs (Process), as well as integrating services with secondary care (Outer Setting). Despite challenges such as staffing, participants believed the service would effectively address patient needs if adequately supported.

Conclusion
The implementation of pharmacist-led anticoagulation services in primary care settings was identified as both feasible and essential for improving patient outcomes. The insights from this study can inform future initiatives aimed at enhancing anticoagulation management in primary care settings.
Metabolic-Associated Fatty Liver Disease and Weight Loss After Bariatric Surgery: A Systematic Review and Meta-Analysis
Authors: Sabench Fatima , Rusu Elena Cristina , Clavero-Mestres Helena , Arredondo-Prats Vicente , Veciana-Molins Marina , Muñiz-Piera Sara , Vives Margarita , Aguilar Carmen , Bartra Elia , París-Sans Marta , Alibalic Ajla , Quintillà Maria Teresa Auguet 
Published: November 2024

Abstract
Background
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH) are increasingly prevalent in patients undergoing bariatric surgery (BS). Understanding their impact on weight loss outcomes after surgery and highlighting the results of surgical techniques such as Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG) in relation to the presence of MASH are essential for improving patient management and predicting long-term success.

Methods
A systematic review and meta-analysis were conducted. We searched the PubMed database; inclusion criteria were BS patients with liver impairment data at surgery and weight loss data at follow-up of 6 months or longer. Meta-analyses were conducted using R’s meta package, assessing heterogeneity with the I2 statistic and employing subgroup analyses where necessary.

Results
Out of 1126 eligible studies, 22 were included in the final systematic review. For the MASLD vs. Normal Liver (NL) comparison, no significant difference in BMI change was found at 12 months, but subgroup analysis indicated a possible publication bias (published data vs data collected). In the MASH vs. non-MASH comparison, high heterogeneity was noted at 12 months, and further stratification by surgical technique revealed that SG patients with MASH experienced lower weight loss, approaching statistical significance.

Conclusions
MASLD does not significantly affect short-term weight loss outcomes post-BS, but long-term results show variability. Standardized reporting practices and complete data dissemination are essential for future research to enhance meta-analysis reliability and generalizability.

Graphical Abstract
Bridging Academia and Enterprise: A Framework for Collaborative Success
Authors: Tucker Rebeka C. , Robinson Sarita J. , Liyanage Champika L. , Fernandez Proceso L. , Cortez Leah Amor , Montebon Darryl Roy , Tantanee Sarintip , Khiewnavawongsa Sorraya , Chaimoon Nida , Weerasinghe K. D. N. , Gunawardena K. S. L. , Dissanayake Ranjith 
Published: November 2024

AbstractUniversity-enterprise collaboration (UEC) is an essential aspect of research and innovation involving cooperation between universities and industry or other organizations. UEC can lead to economic growth, job creation, and enhanced research outcomes. However, the complexity and diversity of UECs present challenges in developing a practical framework that can guide the development and implementation of such collaborations. The aim of this paper is to develop a UEC framework from the key concepts identified in the literature, which can be adapted to various disciplines/contexts. This research paper is part of an ERASMUS+ project, which aims to strengthen enterprise collaboration for resilient communities in Asia (SECRA). The current paper presents the findings of thematic analysis of existing UEC literature and the resultant conceptual framework. Thematic analysis of eligible literature (N = 84) unveiled four themes and thirty-two sub-themes important to UEC. The proposed UEC framework highlights the importance of several structural, cultural, relational, and material themes and their underpinning concepts for developing successful UECs. The findings can inform future research on UECs, guide UEC practice, and provide the foundations for developing successful UECs. However, further research is needed to test the feasibility and validity of the framework in real-world UEC collaborations and to explore the interactions between different themes, sub-themes, and underlying concepts.
The Problems of Empirically-Informed Arguments for and against Retributivism
Authors: Zisman Valerij , Rehren Paul 
Published: November 2024

AbstractIn recent years, a number of philosophers and social scientists have argued in favor of or against retributive theories of criminal punishment based on empirical findings about folk punitive judgment and decision-making. In this paper, we will argue that these arguments do not succeed. We will raise two objections. First, there are serious gaps between the empirical findings these authors cite and the descriptive premises these findings are meant to support. Second, in many cases, the existing research does not support the specific empirical claims that feature in these arguments. Specifically, a large part of the existing psychological research and some philosophers claim that people are mainly driven by retributive motives. We will show that a large portion of the empirical research is not designed in a way to specifically test this claim, and to the extent that some studies are able to investigate this claim, we show that the evidence suggests that people are motivated by a variety of concerns, including consequentialist motives. We discuss possible responses and implications for the philosophy of criminal punishment, and provide suggestions for improved study designs.
Effect of environmental knowledge on pro-environmental attitudes and behaviors: a comparative analysis between engineering students and professionals in Ciudad Juárez (Mexico)
Authors: Burgos-Espinoza Ingrid Iovana , García-Alcaraz Jorge Luis , Gil-López Alfonso Jesús , Díaz-Reza José Roberto 
Published: November 2024

AbstractThis study examines the effects of environmental knowledge on pro-environmental attitudes and behavior by analyzing the relationship between general environmental knowledge (GEK), specific environmental knowledge (SEK), environmental attitudes (ENA), and public pro-environmental behavior (PPB) in two demographic groups: engineering students from universities and active engineers working in the maquiladora industry, both in Ciudad Juárez (Mexico). A questionnaire was designed based on a literature review, adapted to the Mexican context, and applied to engineers in 21 companies and 3 universities; 1449 valid responses were collected, and a structural equation model was developed to validate the five hypotheses. The findings suggest that SEK exerts a more significant influence on active engineers’ PPB, possibly because of their industry experience and understanding of the environmental consequences of industrial processes. In contrast, engineering students may exhibit less developed PPB despite having a solid theoretical foundation compared to active engineers. These findings have important implications for both groups’ education and development of environmental awareness and strategies.
Using dynamic resistance to predict electrode surface degradation in resistance spot welding of 5182 aluminum alloy
Authors: Nikitin A. , Turabov D. , Ermilova E. , Evdokimov A. , Ossenbrink R. , Seidlitz H. 
Published: November 2024

Abstract
In this study, the correlation between dynamic resistance during the first 10 ms of welding time and the electrode surface condition in resistance spot welding of 5182 aluminum alloy has been investigated. The electrode surface rapidly degrades due to contamination and morphological changes, adversely affecting the weld spot surface. The accumulation of Cu-Al intermetallic phases on the electrode surface alters its roughness, leading to variations in dynamic resistance. By analyzing this correlation, optimal electrode milling intervals were identified to extend electrode life. This work focused on detecting crater formation on the electrode surface through dynamic resistance monitoring. The results indicate that resistance measurements provide a reliable approach for evaluating electrode wear, optimizing maintenance schedules, and reducing material removal during milling.
Frieden fühlen? Emotionale (Be)Deutungen von innerem Frieden nach Konflikt und Flucht
Authors: Edler Hannah , Krause Ulrike 
Published: November 2024

ZusammenfassungWährend der Nexus von Konflikt und Flucht intensiv untersucht wird, bleibt Frieden bislang vernachlässigt. In unserer Forschung widmen wir uns dieser Lücke und legen den Fokus auf Friedenswahrnehmungen und -praktiken von geflüchteten Menschen in Deutschland. Gesprächspartner*innen schreiben allen voran innerem Frieden – und somit Frieden zu fühlen – besondere Bedeutung zu. Analysiert durch einen emotional-affektiven Ansatz und mithilfe migrantisch situierten Wissens legen wir dar, dass innerer Frieden auf ihren intersektional geprägten Erfahrungen von Konflikt, Gewalt und Flucht beruht und interdependent mit Hoffen, Erleben und Handeln verknüpft ist. Inneren Frieden assoziieren sie mit diversen emotionalen Zuschreibungen, wie Glück und Zufriedenheit, und beschreiben ihn als Basis für ihr Hoffen auf ein normales Leben, ihre Bewältigung traumatischer Erfahrungen sowie ihre Motivation für individuelles und kollektives Handeln. Die Analyse zeigt daher, wie innerer Frieden mit Vergangenheit, Gegenwart und Zukunft emotional verbunden ist und Handlungsmotivationen affektiv prägt.
Non-drinking and social life in adolescence: a qualitative study in Switzerland
Authors: Chok Lorraine , Suris Joan-Carles , Vittoz Lucie , Palhares Diana Fernandes , Barrense-Dias Yara 
Published: November 2024

Abstract

Background
Alcohol consumption is popular among adolescents and young people and adolescent non-drinkers may be socially excluded and/or stigmatized. The aim of this qualitative study was to explore the social life of young non-drinkers (14–20 years old), to understand how they live their non-drinking and how they are perceived by their drinking peers.

Methods
We conducted a qualitative research on non-consumption of alcohol in the French-speaking region of Switzerland. Our study included 63 young people divided into 12 focus groups aged 14 to 20 years.

Results
Overall, young non-drinkers would be a minority in their peer groups, leading some of them to feel out of the norm. Participants reported that not drinking alcohol is generally questioned and non-drinkers are almost always asked to justify their non-consumption. Finally, non-drinkers are sometimes automatically designated as resources who have to control the drinking of others and/or are the ones who help their drinking-peers if they are drunk and need help, a status that can put them under pressure.

Conclusions
It is important to normalize the non-consumption of alcohol and make non-drinkers visible by including them in school-based prevention interventions.
Reliability and validity evidence of the Swedish shortened mathematics anxiety rating scale elementary (MARS-E)
Authors: Finell Jonatan , Eklöf Hanna , Korhonen Johan , Jonsson Bert 
Published: November 2024

AbstractThe current study assessed reliability and validity evidence of the shortened Swedish Mathematics Anxiety Rating Scale—Elementary (MARS-E), using data from three time points. After initial pilot tests, a total of 429 students participated in the study, completing the MARS-E twice during grade 4 and once during grade 5. Confirmatory factor analyses supported a one-factor structure at each timepoint. The scale displayed both longitudinal and gender measurement invariance across timepoints, ensuring both stability and fairness across gender and time. Factor correlations with criterion variables were examined, revealing a strong correlation between math anxiety (MA) and test anxiety (TA) (r = 0.707). However, the two constructs had distinct relationships to other criterion variables, such as math performance (rma = − 0.343, rta = − 0.110) and self-concept in math (rma = − 0.580, rta = − 0.273). Gender correlations provided evidence of girls being more strongly associated with higher math anxiety scores compared to boys. The current paper provides evidence of the Swedish MARS-E as a valid, easily interpreted, unidimensional instrument for measuring math anxiety in Swedish primary school students. Additionally, the study highlights the gender disparities concerning math anxiety as early as grades 4 and 5.
Was braucht es, um forschungsfit zu sein?
Authors: Wolf Florian , Klanke Merle , Klein Astrid-Alexandra , Kuschick Doreen , Lingner Heidrun , Löscher Susanne , Stark Stefanie , Mergenthal Karola 
Published: November 2024

Zusammenfassung
Hintergrund
Allgemeinmedizinische Institute und Forschungspraxennetze stehen fortwährend vor der Herausforderung, wie sie hausärztliche Praxisteams an Forschungsvorhaben aktiv und nachhaltig beteiligen können. In Deutschland gibt es derzeit keine standardisierten Research-ready-Kriterien.

Fragestellung
Was braucht es aus der Sicht von hausärztlichen Praxisteams, um an Forschungsprojekten teilnehmen zu können?

Material und Methoden
Drei Fokusgruppendiskussionen wurden mit insgesamt 13 Hausärzt*innen (HÄ) und 12 Medizinischen Fachangestellten (MFA) im Februar und März 2023 durchgeführt. Die Voraussetzungen für eine empfundene Forschungseinsatzfähigkeit („research readiness“) wurden im Rahmen von drei Studiendesigns erfragt und diskutiert. Anhand der Beobachtungsprotokolle und der Whiteboardaufzeichnungen erfolgte eine qualitative Inhaltsanalyse nach Kuckartz.

Ergebnisse und Diskussion
Es konnten sowohl studienspezifische als auch studienübergreifende Voraussetzungen identifiziert werden. Um sich forschungsfit zu fühlen, benötigen HÄ und MFA nicht nur die Unterstützung und Koordination durch die Studienverantwortlichen. Auch die eigene Bereitschaft und entsprechende Ressourcen müssen innerhalb des Praxisteams vorhanden sein. Die Erkenntnisse der Diskussionsrunden fließen in die Erstellung eines Research-ready-Konzepts für Forschungspraxennetze in Deutschland ein.
Identified candidate genes for pig mental health: Insights from intensive farming systems
Authors: Wei Xingyu , Xu Lingyao , Jiang Jinyun , Miao Jian , Wu Fen , Chen Zitao , Zhang Zhe , Wang Qishan , Pan Yuchun , Wang Zhen 
Published: November 2024

Abstract
Understanding the genetic basis of porcine mental health (PMH)-related traits in intensive pig farming systems may promote genetic improvement animal welfare enhancement. However, investigations on this topic have been limited to a retrospective focus, and phenotypes have been difficult to elucidate due to an unknown genetic basis. Intensively farmed pigs, such as those of the Duroc, Landrace, and Yorkshire breeds, have undergone prolonged selection pressure in intensive farming systems. This has potentially subjected genes related to mental health in these pigs to positive selection. To identify genes undergoing positive selection under intensive farming conditions, we employed multiple selection signature detection approaches. Specifically, we integrated disease gene annotations from three human gene–disease association databases (Disease, DisGeNET, and MalaCards) to pinpoint genes potentially associated with pig mental health, revealing a total of 254 candidate genes related to PMH. In-depth functional analyses revealed that candidate PMH genes were significantly overrepresented in signaling-related pathways (e.g., the dopaminergic synapse, neuroactive ligand‒receptor interaction, and calcium signaling pathways) or Gene Ontology terms (e.g., dendritic tree and synapse). These candidate PMH genes were expressed at high levels in the porcine brain regions such as the hippocampus, amygdala, and hypothalamus, and the cell type in which they were significantly enriched was neurons in the hippocampus. Moreover, they potentially affect pork meat quality traits. Our findings make a significant contribution to elucidating the genetic basis of PMH, facilitating genetic improvements for the welfare of pigs and establishing pigs as valuable animal models for gaining insights into human psychiatric disorders.
A one-year hospital system review of plasma next-generation sequencing in a mixed population
Authors: Drake Ty C. , Babic Jessica , Wanger Audrey , Chavez Violeta 
Published: November 2024

Abstract

Objective:
To describe the use of plasma next-generation sequencing (NGS) and determine if it provided additional information from routine tests or lead to change in antimicrobial management.

Design and Setting:
This retrospective cohort study evaluated patients with a NGS test performed who were admitted to a hospital health system in the greater Houston area between May 2022 and May 2023.

Patients:
In total, 143 NGS tests were ordered in the span of one year for 135 unique patients. Most patients were ≥ 18 years (74.1%), White/Caucasian (43.7%), male (61.5%), and immunocompetent (54.1%). Eight patients had repeat tests during the study period, four being after an initial rejected test, and the rest being greater than 7 days from the initial test.

Results:
Of the 139 NGS tests performed, 56 (40%) were positive. When compared to routine testing, 49 (35%) were negative when routine testing was negative, 15 (11%) positive were concordant with routine testing, 29 (21%) positive were discordant from routine testing, 17 (12%) negative while routine testing was positive, and 29 (21%) were positive while routine testing was negative. Documented changes in antimicrobial due to NGS occurred after 16 (13.6%) tests, with the majority of these changes occurring in immunocompromised patients (14/16 [88%]).

Conclusions:
NGS provided additional data when compared to routine testing but rarely resulted in antimicrobial changes. The majority of changes occurred in immunocompromised patients. Diagnostic stewardship is a vital component for this type of NGS testing and others in which guidelines do not exist.