bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan multimedia pembelajaran interaktif kimia berbasis android menggunakan prinsip mayer pada materi laju reaksi
Authors: Putri Dian Puspita Eka , Muhtadi Ali 
Published: October 2018

Tujuan penelitian adalah(1) mengetahui karakteristik produk multimedia yang layak untuk materi laju reaksi (2) menguji keefektivan produk dalam meningkatkan capaian hasil belajar kognitif. Penelitian dilakukan di kelas XI IPA 3 SMAN 9 Yogyakarta. Metode penelitian R & D dari model Alessi and Trollip. Subjek uji coba adalah 3 ahli media dan 3 ahli materi pada uji alpha, 1 guru kimia dan 5 orang siswa pada uji beta, dan 30 siswa pada uji validasi. Pengumpulan data menggunakan observasi, wawancara, angket, dan tes. Data dianalisis secara deskriptif kualitatif dan perhitungan statistik. Hasil penelitian: (1) produk sangat layak (2) karakteristiknya dapat memvisualisasikan konsep laju reaksi, tersusun atas beberapa jenis media penggunaan dikontrol siswa, memenuhi perbedaan kecepatan belajar, dan dikemas dalam bentuk aplikasi berbasis android. Oleh karena itu, pembelajaran dengan produk yang dihasilkan dapat dilakukan dimana saja dan kapan saja; (3) produk terbukti efektif dalam meningkatkan capaian hasil belajar kognitif pada materi laju reaksi.Kata kunci: multimedia pembelajaran interaktif, laju reaksi, capaian hasil belajar kognitif DEVELOPING INTERACTIVE MULTIMEDIA LEARNING CHEMISTRY BASED ON ANDROID WITH MAYER’S PRINCIPLES ON RATE REACTION COURSEAbstractThis study aims to: (1) determine the effectiveness of multimedia products interactive learning based on Android using the principles of Mayer viable in the material reaction rate. (2) test the effectiveness product to improve outcomes cognitive achievement of students in the material rate reaction. This research was conducted in SMAN 9 Yogyakarta by using research and development methods (R & D), followed the model Alessi and Trollip. Subject trials of investigational products were the three experts of media and three experts material on the alpha test, one chemistry teacher and 5 students grade XI students in beta test and 30 students of class XI IPA 3 SMAN 9 Yogyakarta on validity test the effectiveness of the product. The collection of data was done through observation, interviews, questionnaires, and tests. Data were analyzed by descriptive qualitative and statistical calculations. The results show: (1) the products considered to be feasible, (2) the product has characteristic can visualize the concept of reaction rate, composed of several types of media, the activity can be controlled by students, can meet the student's pace difference, can be installed on android smartphone can be done learn; (3) the product proved effective in raising the achievement of the cognitive learning.Keywords: multimedia interactive learning, rate reaction, cognitive learning outcomes
Pengembangan video pembelajaran bumbu dan rempah pada mata pelajaranpengolahan makanan kontinental
Authors: Demayanti Febria , Soenarto Sunaryo 
Published: October 2018

Penelitian ini bertujuan: (1) menghasilkan materi video yang layak digunakan sebagai media pembelajaran bagi siswa SMK Jurusan Tata Boga secara umum, dan secara khusus untuk SMK Ma’Arif 2 Sleman. Materi video lebih menekankan pada pengenalan bumbu dan rempah kontinental (continental spice) pada mata pelajaran Pengolahan Makanan Kontinental; (2) mendokumentasikan beberapa bumbu dan rempah kontinental (continental spice) secara detail, meliputi: bentuk, sifat, karakter dan kegunaan bahan tersebut; (3) mengetahui manfaat penggunaan media video pembelajaran dalam meningkatkan hasil belajar siswa. Penelitian pengembangan ini merujuk 3 langkah yang dikembangkan antara lain: (a) praproduksi; (b) produksi; dan (c) pascaproduksi. Uji coba program video dilakukan 2 tahap yaitu skala kecil dan besar. Produk video yang telah direvisi digunakanuntuk pembelajaran PMK. Subjek tes sebelum dan sesudah pembelajaran menggunakan media video untuk mengetahui peningkatan hasil belajar. Pengumpulan data menggunakan teknik wawancara, observasi, dan angket. Teknik analisis menggunakan deskriptif. Validasi ahli materi dan ahli media hasilnya layak digunakan. Penilaian siswa tentang media video pembelajaran bumbu dan rempah kontinental rata-rata siswa memberi tanggapan “sangat layak” serta terdapat peningkatan hasil belajar siswa sesudah menggunakan program video pembelajaran.Kata kunci: video pembelajaran, bumbu dan rempah kontinental, hasil belajar DEVELOPING A VIDEO FOR THE LEARNING OF INGREDIENTS AND SPICES IN THE SUBJECT OF CONTINENTAL CUISINE PROCESSINGAbstractThis study aims to: (1) produce video materials appropriate to be used as learning media for students of Gastronomy in the vocational high school in general and in SMK Ma’arif 2 Sleman in particular; the video materials emphasize the introduction to continental ingredients and spices in the subject of Continental Cuisine Processing; (2) document several continental ingredients and spices in detail including their forms, nature, characters, and uses; and (3) investigate the benefits of the use of the learning video to improve students’ learning achievement. This was a research and development pouting 3 to the steps developed i.e.: (a) preproduction, (b) production, and (c) post-production. Video program testing is done in 2 to the steps; large & small scale. Revised video products are used for PMK learning. Tes subjects before and after learning using video media to the know the improvement of learning outcomes. The data were collected by interview technique, observation, and questioner. The analysis techniques were use descriptive. The results of the validation by the materials and media experts of the results is feasible to be used. The students’ assessment of the video for the learning of continental ingredients and spices show very appropriate responses on the average and there is an increase on the learning outcome after using the learning video program.Keywords: learning video, continental ingredients and spices, learning achievement
Pengembangan e-book interaktif mata pelajaran teknologi informasi dan komunikasi (TIK) untuk SMK kelas X
Authors: Fathoni Muhammad Ihsaan , Marpanaji Eko 
Published: October 2018

Penelitian ini bertujuan untuk: (1) mendeskripsikan pengembangan produk media pembelajaran e-book interaktif TIK yang layak pada peserta didik kelas X SMK N 2 Yogyakarta, dan (2) mengetahui efektifitas produk media pembelajaran e-book interaktif TIK terhadap hasil belajar peserta didik kelas X SMK N 2 Yogyakarta.Penelitian pengembangan ini mengacu langkah yang dikembangkan oleh Alessi & Trollip. Prosedur pengembangan terdiri dari dari tiga fase, yaitu perencanaan, desain, dan pengembangan. Pengumpulan data dilakukan menggunakan lembar validasi produk untuk ahli media, lembar validasi produk untuk ahli materi, kuisioner untuk pengguna, dan tes hasil belajar. Teknik analisis data menggunakan teknik deskriptif kualitatif dan kuantitatif.Hasil penelitian menunjukkan bahwa media pembelajaran e-book interaktif TIK dinilai sangat baik yang diperoleh melalui uji alpha dan uji beta, sehingga layak digunakan sebagai sumber belajar peserta didik. Uji efektivitas menunjukkan bahwa penggunaan media pembelajaran e-book interaktif TIK lebih efektif daripada pembelajaran TIK biasa. Rerata N-gain antara kelas eksperimen dan kelas kontrol menunjukkan bahwa nilai nilai kelas eksperimen lebih tinggi daripada kelas kontrol dan berbeda secara signifikan.Kata kunci: TIK, e-book, interaktif DEVELOPING INTERACTIVE E-BOOK ON INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) LESSON FOR GRADE OF VOCATIONAL HIGH SCHOOLAbstractThis study aimed to: (1) describe the development of instructional media products based on appropriate ICT interactive e-book on students for grade of SMK N 2 Yogyakarta, and (2) to know the effectiveness of ICT interactive e-book based learning e-book products on participants' learning outcomes for 10th grade of SMK N 2 Yogyakarta. This development research refers to the steps developed by Alessi & Trollip. The development procedure consisted of three phases, namely planning, design, and development. Data collection was performed using product validation sheets for media experts, product validation sheets for material experts, questionnaires for users, and learning result tests. The data analysis techniques used qualitative and quantitative descriptive techniques. The result of the research showed that ICT interactive e-book learning media was very good which was proved through alpha test and beta test, so it was suitable to be used as a learning resource for learners. The effectiveness test showed that the use of interactive ICT e-book learning media was more effective than regular ICT learning. The mean N-gain between the experimental class and the control class indicated that the value of the experiment class grade was higher than the control class and differed significantly.Keywords: ICT, e-book, interactive
Nature and Diffusion of Gynecologic Cancer–Related Misinformation on Social Media: Analysis of Tweets
Authors: Chen Liang , Wang Xiaohui , Peng Tai-Quan 
Published: October 2018

BackgroundOver the last two decades, the incidence and mortality rates of gynecologic cancers have increased at a constant rate in China. Gynecologic cancers have become one of the most serious threats to women’s health in China. With the widespread use of social media, an increasing number of individuals have employed social media to produce, seek, and share cancer-related information. However, health information on social media is not always accurate. Health, and especially cancer-related, misinformation has been widely spread on social media, which can affect individuals’ attitudinal and behavioral responses to cancer.ObjectiveThe aim of this study was to examine the nature and diffusion of gynecologic cancer–related misinformation on Weibo, the Chinese equivalent of Twitter.MethodsA total of 2691 tweets related to 2 gynecologic cancers—breast cancer and cervical cancer—posted on Weibo from June 2015 to June 2016 were extracted using the Python Web Crawler. Two medical school graduate students with expertise in gynecologic diseases were recruited to code the tweets to differentiate between true information and misinformation as well as to identify the types of falsehoods. The diffusion characteristics of gynecologic cancer–related misinformation were compared with those of the true information.ResultsWhile most of the gynecologic cancer–related tweets provided medically accurate information, approximately 30% of them were found to contain misinformation. Furthermore, it was found that tweets about cancer treatment contained a higher percentage of misinformation than prevention-related tweets. Nevertheless, the prevention-related misinformation diffused significantly more broadly and deeply than true information on social media.ConclusionsThe findings of this study suggest the need for controlling and reducing the cancer-related misinformation on social media with the efforts from both service providers and medical professionals. More specifically, it is important to correct falsehoods related to the prevention of gynecologic cancers on social media and increase individuals’ capacity to assess the veracity of Web-based information to curb the spread and thus minimize the consequences of cancer-related misinformation.
Infeksi Virus Peste de Petits Ruminants (PPR) pada Kambing dan Domba di Indonesia
Authors: Sendow Indrawati , Adjid Raden Mohamad Abdul 
Published: October 2018

Peste des petits ruminants (PPR) merupakan salah satu penyakit virus pada kambing dan domba yang ditandai dengan peradangan pada saluran pencernaan dan pernafasan. Penyakit ini masuk dalam “daftar penyakit” yang dibuat oleh OIE. Keberadaan penyakit ini di Indonesia belum pernah dilaporkan sehingga perlu dilakukan surveilan secara serologis pada kambing dan domba untuk mendapatkan informasi awal keberadaan antibodi terhadap virus PPR. Sebanyak 680 sampel serum kambing dan domba yang berasal dari Rumah Potong Hewan (RPH) Jakarta dan pedagang/pengumpul kambing dan domba di Jakarta pada tahun 2014 telah dikoleksi. Hasil pengujian dengan uji kompetitif ELISA yang menggunakan antigen inaktif (recombinant nucleoprotein- NP), menunjukkan bahwa telah terdeteksi antibodi terhadap virus PPR dengan prevalensi 0,2% pada kambing dan 1,7 % pada domba asal RPH Jakarta. . Berdasarkan lokasi asal ternak yang masuk ke RPH Jakarta, prevalensi tertinggi diperoleh dari Indramayu (2,8%), Solo 0.75%. Serum yang positif, beberapa negatif dan dubius tersebut kemudian diuji untuk dikonfirmasi di Australian Animal Health Laboratory (AAHL) menggunakan uji ELISA dan menunjukkan hasil yang konsisten yaitu tetap positif atau negatif. Selanjutnya dilakukan pengambilan sampel serum dari domba dan kambing di beberapa kabupaten Indramayu pada tahun 2016. Hasil menunjukkan bahwa seluruh sampel sebanyak 326 sera telah diuji dengan uji ELISA hasilnya negatif. Hasil penelitian ini memperlihatkan bahwa infeksi PPR masih sangat rendah, namun hasil ini dapat menunjukkan indikasi awal adanya infeksi PPR di Indonesia. Oleh karena itu, kewaspadaan terhadap meningkatnya kejadian infeksi PPR di Indonesia perlu mendapat perhatian.
Studi Distribusi Glukosa Transporter 4 pada Otot Skelet Ayam Kedu Cemani
Authors: Budipitojo Teguh , - Ariana , Pangestiningsih Tri Wahyu , Wijayanto Hery , Kusindarta Dwi Liliek , Musana Dewi Kania 
Published: October 2018

Glucose transporter (GLUT 4) is glucose transporter protein regulated by insulin, found in adipose tissue and striated muscle (skeletal and cardiac muscle). Kedu cemani chicken is one of Indonesia endemic animal, found in Kedu, Temanggung regency, Central Java. This study was required to complete microscopic documentation of Indonesia’s native biodiversity. The objective of this study was to clarify GLUT 4 distribution in skeletal muscle fibers of kedu cemani chicken by using avidin-biotin-peroxidase complex (ABC) immunohistochemistry method. This study was conducted by using pectorales major, biceps brachii, and biceps femoris muscle tissue from 5 kedu cemani chicken. The result showed that GLUT 4 immunoreactivity were detected in sarcolemma and myofibrils component of pectorales major, biceps brachii, and biceps femoris muscle tissue. Intensity of GLUT 4 immunorectivites increased from weak intensity in pectorales major muscle tissue, moderate intensity in biceps brachii muscle tissue, then strong intensity in biceps femoris muscle tissue. This result might motivate to further exploration about the other kedu cemani chicken specific features to complete microscopic documentation of Indonesia’s native biodiversity.
PANEL COINTEGRATION: LONG-RUN RELATIONSHIP BETWEEN INTERNET, ELECTRICITY CONSUMPTION AND ECONOMIC GROWTH. EVIDENCE FROM OECD COUNTRIES
Authors: Kirikkaleli Dervis , Sokri Abderrahmane , Candemir Mehmet , Murat Ertugrul Hasan 
Published: October 2018

<p>The linkage between electricity consumption, internet demand and economic growth is aimed to investigate in this study in 35 OECD countries for the period 1993-2014. Panel cointegration, Fully Modified Ordinary Least Squares (FMOLS), Dynamic Ordinary Least Squares (DOLS) and Dumitrescu-Hurlin causality tests were performed to capture the potential long-run and causal linkages among the three variables. The findings from the FMOLS and DOLS models indicate a positive linkage between electricity, internet demand and economic growth in the long-run. Results from the Dumitrescu-Hurlin causality confirm feedback causality between electricity consumption and internet demand and unilateral causality running from economic growth to electricity consumption.</p>
Prolonged Prothrombotic Effects of Antecedent Hypoglycemia in Individuals With Type 2 Diabetes
Authors: Chow Elaine , Iqbal Ahmed , Walkinshaw Emma , Phoenix Fladia , Macdonald Ian A. , Storey Robert F. , Ajjan Ramzi , Heller Simon R. 
Published: October 2018

OBJECTIVE
Hypoglycemia has been linked to persistent increases in cardiovascular (CV) mortality in type 2 diabetes after the event. Our aim was to examine acute and downstream effects of hypoglycemia on markers of thrombosis risk and inflammation in type 2 diabetes.

RESEARCH DESIGN AND METHODS
Twelve individuals with type 2 diabetes with no history of CV disease and 11 age- and BMI-matched volunteers without diabetes underwent paired hyperinsulinemic-euglycemic (glucose 6 mmol/L for two 60-min periods) and hypoglycemic (glucose 2.5 mmol/L for two 60-min periods) clamps on separate occasions on day 0. Fibrin clot properties, platelet reactivity, and inflammatory markers were measured at baseline, end of and after recovery from the initial clamp, day 1, and day 7 using validated assays and electron microscopy.

RESULTS
Euglycemic hyperinsulinemia reduced platelet reactivity, decreased fibrin clot density, and improved fibrinolytic efficiency in both groups. Platelet reactivity and aggregation increased during acute hypoglycemia in both groups, resolving at recovery. In type 2 diabetes, clot lysis times and clot maximum absorbance increased up to day 7 (P = 0.002 and 0.001 vs. euglycemia, respectively), but clots from control subjects without diabetes showed limited changes. Fibrin network density increased Δ 1.15 ± 0.28 fibers/μm2 at day 7 after the hypoglycemic clamp (P &lt; 0.01 for glycemic arm), whereas fibrinogen and complement C3 increased after hypoglycemia up to day 7 in type 2 diabetes only.

CONCLUSIONS
Antecedent hypoglycemia has acute and persistent prothrombotic effects, lasting at least 7 days, that were enhanced in individuals with type 2 diabetes. These findings identify mechanisms by which hypoglycemia might increase short- and medium-term risk of CV mortality.
Area Deprivation and Regional Disparities in Treatment and Outcome Quality of 29,284 Pediatric Patients With Type 1 Diabetes in Germany: A Cross-sectional Multicenter DPV Analysis
Authors: Auzanneau Marie , Lanzinger Stefanie , Bohn Barbara , Kroschwald Peter , Kuhnle-Krahl Ursula , Holterhus Paul Martin , Placzek Kerstin , Hamann Johannes , Bachran Rainer , Rosenbauer Joachim , Maier Werner 
Published: October 2018

OBJECTIVEThis study analyzed whether area deprivation is associated with disparities in health care of pediatric type 1 diabetes in Germany.RESEARCH DESIGN AND METHODSWe selected patients &lt;20 years of age with type 1 diabetes and German residence documented in the “diabetes patient follow-up” (Diabetes-Patienten-Verlaufsdokumentation [DPV]) registry for 2015/2016. Area deprivation was assessed by quintiles of the German Index of Multiple Deprivation (GIMD 2010) at the district level and was assigned to patients. To investigate associations between GIMD 2010 and indicators of diabetes care, we used multivariable regression models (linear, logistic, and Poisson) adjusting for sex, age, migration background, diabetes duration, and German federal state.RESULTSWe analyzed data from 29,284 patients. From the least to the most deprived quintile, use of continuous glucose monitoring systems (CGMS) decreased from 6.3 to 3.4% and use of long-acting insulin analogs from 80.8 to 64.3%, whereas use of rapid-acting insulin analogs increased from 74.7 to 79.0%; average HbA1c increased from 7.84 to 8.07% (62 to 65 mmol/mol), and the prevalence of overweight from 11.8 to 15.5%, but the rate of severe hypoglycemia decreased from 12.1 to 6.9 events/100 patient-years. Associations with other parameters showed a more complex pattern (use of continuous subcutaneous insulin infusion [CSII]) or were not significant.CONCLUSIONSArea deprivation was associated not only with key outcomes in pediatric type 1 diabetes but also with treatment modalities. Our results show, in particular, that the access to CGMS and CSII could be improved in the most deprived regions in Germany.
Prediabetes Is Associated With Structural Brain Abnormalities: The Maastricht Study
Authors: van Agtmaal Marnix J.M. , Houben Alfons J.H.M. , de Wit Vera , Henry Ronald M.A. , Schaper Nicolaas C. , Dagnelie Pieter C. , van der Kallen Carla J. , Koster Annemarie , Sep Simone J. , Kroon Abraham A. , Jansen Jacobus F.A. , Hofman Paul A. , Backes Walter H. , Schram Miranda T. , Stehouwer Coen D.A. 
Published: October 2018

OBJECTIVE
Structural brain abnormalities are key risk factors for brain diseases, such as dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain abnormalities already occur in prediabetes. Therefore, we investigated whether both prediabetes and type 2 diabetes are associated with lacunar infarcts (LIs), white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and brain atrophy.

RESEARCH DESIGN and METHODS
We used data from 2,228 participants (1,373 with normal glucose metabolism [NGM], 347 with prediabetes, and 508 with type 2 diabetes (oversampled); mean age 59.2 ± 8.2 years; 48.3% women) of the Maastricht Study, a population-based cohort study. Diabetes status was determined with an oral glucose tolerance test. Brain imaging was performed with 3 Tesla MRI. Results were analyzed with multivariable logistic and linear regression analyses.

RESULTS
Prediabetes and type 2 diabetes were associated with the presence of LIs (odds ratio 1.61 [95% CI 0.98–2.63] and 1.67 [1.04–2.68], respectively; Ptrend = 0.027), larger WMH (β 0.07 log10-transformed mL [log-mL] [95% CI 0.00–0.15] and 0.21 log-mL [0.14–0.28], respectively; Ptrend &lt;0.001), and smaller white matter volumes (β −4.0 mL [−7.3 to −0.6] and −7.2 mL [−10.4 to −4.0], respectively; Ptrend &lt;0.001) compared with NGM. Prediabetes was not associated with gray matter volumes or the presence of CMBs.

CONCLUSIONS
Prediabetes is associated with structural brain abnormalities, with further deterioration in type 2 diabetes. These results indicate that, in middle-aged populations, structural brain abnormalities already occur in prediabetes, which may suggest that the treatment of early dysglycemia may contribute to the prevention of brain diseases.
Increased Prevalence of Type 2 Diabetes–Related Complications in Combined Type 2 Diabetes and Sickle Cell Trait
Authors: Skinner Sarah C. , Diaw Mor , Pialoux Vincent , Mbaye Maïmouna Ndour , Mury Pauline , Lopez Philomène , Bousquet Delphine , Gueye Fatou , Diedhiou Demba , Joly Philippe , Renoux Céline , Sow Djiby , Diop Saliou , Ranque Brigitte , Vinet Agnès , Samb Abdoulaye , Guillot Nicolas , Connes Philippe 
Published: October 2018

OBJECTIVE
The prevalence of type 2 diabetes (T2D) is rapidly increasing in sub-Saharan Africa, where sickle cell trait (SCT) is also frequent. Although SCT is generally considered a benign condition, evidence suggests that SCT could exaggerate vascular dysfunction in T2D. However, it remains unclear whether SCT could increase the risk of the development of T2D complications. Therefore, this study was conducted to determine whether T2D complications were more prevalent among Senegalese individuals with SCT and T2D than among those with T2D only.

RESEARCH DESIGN AND METHODS
Rates of hypertension, retinopathy, peripheral neuropathy, peripheral artery disease, and impaired renal function as well as arterial stiffness, blood rheology, and concentrations of plasma advanced glycation end products (AGEs) and cytokines were compared between groups of Senegalese individuals with combined SCT and T2D (T2D-SCT) (n = 60), T2D (n = 52), SCT (n = 53), and neither T2D nor SCT (control) (n = 56). Human aortic endothelial cell (HAEC) expression of inflammatory and adhesion factors was measured after treatment with tumor necrosis factor-α and subjects’ plasma. Effects of AGE inhibition or tiron on HAEC expression of E-selectin were measured.

RESULTS
Retinopathy, hypertension, and reduced renal function were more prevalent, and arterial stiffness, blood viscosity at high shear rates, and thixotropic index were higher, in the T2D-SCT group compared with the other groups. Multivariable analysis showed that plasma AGE concentration was significantly associated with arterial stiffness. E-selectin expression was elevated in HAECs treated with T2D-SCT plasma compared with the other groups, but AGE inhibition reversed this.

CONCLUSIONS
SCT could potentially augment the risk of the development of T2D-related complications, including retinopathy, nephropathy, and hypertension.