bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of treatment for concussion-related convergence insufficiency: The CONCUSS study protocol for a randomized clinical trial
Authors: Alvarez Tara L. , Scheiman Mitchell , Gohel Suril , Hajebrahimi Farzin , Noble Melissa , Sangoi Ayushi , Yaramothu Chang , Master Christina L. , Goodman Arlene 
Published: November 2024

Purpose
To describe CONCUSS, a randomized clinical trial (RCT) designed to compare the following: the effectiveness of immediate office-based vergence/accommodative therapy with movement (OBVAM) to delayed OBVAM as treatments for concussion-related convergence insufficiency (CONC-CI) to understand the impact of time (watchful waiting), the effect of OBVAM dosage (12 versus 16 therapy sessions), and to investigate the underlying neuro-mechanisms of OBVAM on CONC-CI participants.

Methods
CONCUSS is an RCT indexed on https://clinicaltrials.gov/study/NCT05262361 enrolling 100 participants aged 11–25 years with medically diagnosed concussion, persistent post-concussive symptoms 4–24 weeks post-injury, and symptomatic convergence insufficiency. Participants will receive standard concussion care and will be randomized to either immediate OBVAM or delayed (by six weeks) OBVAM. At the Outcome 1 examination (week 7), clinical assessments of success as determined by changes in the near point of convergence (NPC), positive fusional vergence (PFV), and symptoms will be compared between the two treatment groups. After the Outcome 1 visit, those in the delayed group receive 16 visits of OBVAM, while those in the immediate OBVAM group receive four more therapy visits. Outcome 2 assessment will be used to compare both groups after participants receive 16 sessions of OBVAM. The primary measure is the between-group differences of the composite change in the NPC and PFV at the Outcome 1 visit. Secondary outcome measures include individual clinical measures, objective eye-tracking parameters, and functional brain imaging.

Conclusions
Major features of the study design include formal definitions of conditions and outcomes, standardized diagnostic and treatment protocols, a delayed treatment arm, masked outcome examinations, and the incorporation of objective eye movement recording and brain imaging as outcome measures. CONCUSS will establish best practices in the clinical care of CONC-CI. The objective eye movement and brain imaging, correlated with the clinical signs and symptoms, will determine the neuro-mechanisms of OBVAM on CONC-CI.
Phytochemical screening, nutritional, antinutritional, antioxidant, GCMS and mineral analysis of Zanthoxylum rhetsa (Roxb.) DC: Insights from tribal consumption in Mizoram, Northeast India
Authors: Lalhumhima  , Ralte V , Lalbiakdika  , Lalbiaknunga J 
Published: November 2024

The plant Zanthoxylum rhetsa Roxb, a member of the Rutaceae family, holds dual significance in certain communities, particularly in Mizoram, Northeast India, where it is valued for its medicinal properties and consumed as a vegetable. This study comprehensively analyzes the phytochemical, nutritional, antinutritional, and antioxidant properties and the mineral content of Z. rhetsa, a plant traditionally consumed by tribal communities in this region. Minerals such as aluminum, copper, iron, manganese, nickel, and zinc were measured using Atomic Absorption Spectroscopy (AAS). Gas Chromatography-Mass Spectrometry (GC-MS) analysis was conducted to determine the chemical composition of the samples. Phytochemical screening revealed the existence of several bioactive components, such as tannins and flavonoids, while nutritional studies validated the plant's abundance of key nutrients. Among the minerals, manganese was found in the highest concentration (481.356 mg/100 g of DW), while nickel was present in the lowest concentration (1.614 mg/100 g of DW). The total calorific content was ascertained to be 51.344 Kcal/100g, adequate for dietary requirements. Additionally, the total phenolic content measured was 8.28 mg/g in gallic acid equivalent, and the total flavonoid content was 43.04 mg/g in quercetin equivalents. The existence of antinutritional compounds in differing amounts necessitates meticulous evaluation, particularly with the intake of fruits that may possess elevated levels of these substances. This comprehensive assessment highlights the nutritional significance of Z. rhetsa in local diets, emphasizing its dual role as a source of beneficial nutrients and potential antinutritional factors.
Jordans’ anomaly in Chanarin-Dorfman syndrome
Authors: Sánchez-Cortés Jorge , Gabaldó-Barrios Xavier 
Published: November 2024

Abstract

Objectives
Chanarin-Dorfman syndrome is a rare disease inherited in an autosomal recessive pattern whose prevalence does not exceed 130 cases worldwide.

Case presentation
A 4-year-old patient with generalized erythematous-desquamative ichthyosiform syndrome since birth. The main laboratory finding was persistent hypertransaminasemia. Supplementary studies included peripheral blood smear (PBS), which revealed the presence of multiple cytoplasmatic vacuoles in polymorphonuclear leukocytes (PMN) and platelets. Ichthyosiform lesions concomitant to the presence of lipid vacuoles in peripheral blood PMNs are signs of Chanarin-Dorfman syndrome. Diagnostic suspicion was confirmed by genetic sequencing.

Conclusions
Chanarin-Dorfman syndrome is characterized by a mutation in the CGI-58 gene. This gene is involved in the catabolism of long-chain triglycerides stored in cytoplasmic lipid droplets. Jordans’ anomaly is a congenital alteration characterized by the presence of multiple vacuoles in the granulocytic series due to defective lipid metabolism. In this syndrome, long-chain triglycerides build up in tissues, thereby causing dermatological manifestations that are controllable through diet.
Making exploratory search engines using qualitative case studies: a mixed method implementation using interviews with Detroit Artisans
Authors: Robinson Kwame Porter , Garvin Matthew , Eglash Ron , Robert Lionel , Guzdial Mark , Bennett Audrey 
Published: November 2024

Abstract
Search engine algorithms are increasingly subjects of critique, with evidence indicating their role in driving polarization, exclusion, and algorithmic social harms. Many proposed solutions take a top-down approach, with experts proposing bias-corrections. A more participatory approach may be possible, with those made vulnerable by algorithmic unfairness having a voice in how they want to be “found.” By using a mixed methods approach, we sought to develop search engine criteria from the bottom-up. In this project we worked with a group of 16 African American artisanal entrepreneurs in Detroit Michigan, with a majority female and all from low-income communities. Through regular in-depth interviews with select participants, they highlighted their important services, identities and practices. We then used causal set relations with natural language processing to match queries with their qualitative narratives. We refer to this two-step process-- deliberately focusing on social groups with unaddressed needs, and carefully translating narratives to computationally accessible forms--as a “content aware” approach. The resulting content aware search outcomes place themes that participants value, in particular greater relationality, much earlier in the list of results when compared with a standard Web search. More broadly, our use of participatory design with “content awareness” adds evidence to the importance of addressing algorithmic bias by considering who gets to address it; and, that participatory search engine criteria can be modeled as robust linkages between interviews and semantic similarity using causal set relations.
Association between overweight or obesity and vitamin D status in preschool children: an epidemiological survey in Beijing, China, 2021–2023
Authors: Yuan Li , Wang Huiyu , Luo Yan , Wang Lei 
Published: November 2024

Abstract

Background
Previous studies have shown that vitamin D deficiency is a risk factor for obesity in children and adolescents, but most focus on school-age children and adolescents, with little attention paid preschoolers.

Objectives
To explore the relationship between overweight or obesity in the context of vitamin D intake among preschool children in Beijing, and analyze the correlation.

Methods
A total of 51,640 preschoolers (26,775 boys; 24,865 girls), aged 1–6 years, were recruited for physical examination. Overweight or obesity was defined according to the World Health Organization Child Growth and Development Standards (2006 edition). Serum 25-hydroxy (OH) vitamin D levels were determined using standardized liquid chromatography-tandem mass spectrometry (LC-MS/MS), and vitamin D status was evaluated based on the Practice Guide on Clinical Issues Related to Vitamin D Nutrition in Chinese Children (2022).

Results
No significant change was observed in the incidence of overweight (7.72, 7.51, and 7.24 %) or obesity (2.75, 2.63, and 2.40 %) from 2021 to 2023. Among boys, 7.3 % were overweight and 2.8 % were obese. Among girls, 7.6 % were overweight and 2.3 % were obese. Vitamin D deficiency (2.10, 1.70, and 1.01 %) and insufficiency rate (24.09, 18.42, and 15.44 %) showed a decreasing trend. Deficiency or insufficiency was most common in children aged 36–59 months, and serum 25- (OH) vitamin D levels were significantly lower in winter compared to other seasons, with the highest levels in summer. Time spent outdoors was significantly less among children with vitamin D deficiency or insufficiency, and preschoolers who spent more than 2.94 h/day had higher serum vitamin D level. Serum 25- (OH) vitamin D levels were negatively correlated with body mass index (BMI), with overweight or obesity preschoolers showing significantly lower than their normal weight group. After adjusting for age, gender and season, family economic status, guardian educational level and time spent outdoors, the odds of vitamin D deficiency and insufficiency in overweight or obesity in preschoolers were 1.025 (95 % Cl: 1.002–1.174), 1.218 (95 % Cl: 1.099–1.708), respectively.

Conclusions
From 2021 to 2023, there was no significant change in the incidence of overweight or obesity among preschool children in Beijing. Furthermore, the rate of vitamin D deficiency or insufficiency decreased year by year. Vitamin D deficiency or insufficiency associates with factors such as age, season of the year, and time spent outdoors, and there is an association between overweight or obesity and vitamin D status among preschoolers.
Desenvolvimento Sustentável no Contexto da Relação China-América Latina
Authors: de Castro Douglas 
Published: November 2024

Resumo
A parceria entre China e América Latina, enquadrada no contexto do desenvolvimento sustentável, representa um ponto significativo na complexa rede de relações internacionais, especialmente sob a égide da Iniciativa Cinturão e Rota Verde (BRI Verde). Este estudo explora como essa colaboração está reformulando a interação entre a China e América Latina estas regiões, abordando não apenas o crescimento econômico, mas também a sustentabilidade ambiental, em resposta aos desafios impostos pelo modelo de desenvolvimento global predominante, como a degradação ambiental e as disparidades econômicas. Através da análise histórica, percebe-se que o espírito da antiga Rota da Seda, que transcendia os meros aspectos econômicos do comércio, é revivido pelo BRI Verde. Esta iniciativa chinesa é vista como uma abordagem alternativa ao desenvolvimento, que prioriza a cooperação e a sustentabilidade, desafiando os modelos neoliberais promovidos pelas instituições de Bretton Woods após a Segunda Guerra Mundial. A Iniciativa não apenas propõe a construção de infraestrutura, mas também enfatiza a importância das trocas culturais e do entendimento mútuo entre civilizações. O BRI Verde, com seu foco no desenvolvimento sustentável, oferece uma plataforma para que a América Latina aborde suas preocupações ambientais e econômicas, potencializando a transição energética por meio de investimentos em energia renovável e eficiência energética. Este estudo argumenta que a colaboração entre China e América Latina, através do BRI Verde, reflete uma tentativa de desenvolvimento mais equitativo e sustentável, que respeita tanto a soberania quanto as necessidades ambientais e sociais das nações envolvidas. Por fim, a análise destaca a importância de entender as dinâmicas de poder e os contextos históricos que moldam esta parceria, enfatizando a necessidade de uma abordagem crítica e decolonial para avaliar seus impactos na região.
Pérdida de suelo por erosión hídrica en la subcuenca río Estibaná, Panamá
Authors: Castro-Villarreal Jorge Alberto , Villarreal-Núñez José Ezequiel , Cabrera-Rodríguez Juan Adriano 
Published: November 2024

Introducción. La degradación del suelo se desarrolla de forma natural a pequeña escala, sin embargo, la intervención del hombre la ha acelerado y maximizado. La erosión es uno de los principales procesos vinculados a la degradación, esta aunada a sistemas de explotación no adaptados al medio ambiente son la base para la reducción de la productividad y la contaminación de los cuerpos de agua. En Panamá, la degradación de suelo afecta 20 787 km2, área que abarca zonas donde se concentra gran parte de la producción agropecuaria del país. Objetivo. Determinar la pérdida de suelo por erosión hídrica en la subcuenca río Estibaná mediante la implementación de parcelas de erosión. Materiales y métodos. La investigación se desarrolló en la subcuenca río Estibaná, provincia de Los Santos, península de Azuero, Panamá (Arco Seco), durante la época lluviosa (mayo – diciembre) de los años 2020 y 2021. Se utilizó la metodología de parcelas de erosión, con el empleo de un diseño de Bloque Completos al Azar (BCA), en tres localidades, se evaluaron tres tratamientos, con tres repeticiones, donde se determinó escorrentía total, masa de sedimentos transportados (suspendido y precipitado), se realizó un ANDEVA Multifactorial. Resultados. La erosión fue influenciada por factores como pendiente, cobertura del suelo y precipitación. Se determinó que la erosión ascendió a 62,98 Mg/ha/año en suelo desnudo en pendientes de 10 %, con barreras vivas y cobertura del suelo se mitigó el daño por erosión, el comportamiento en otras pendientes presentó un comportamiento similar. Conclusiones. La variación de las precipitaciones en frecuencia, intensidad, duración; así como las intervenciones antrópicas en el medio natural, son los principales causantes del incremento de la pérdida de suelo dentro de la subcuenca río Estibaná. La implementación de labores de conservación de bajo costo puede mitigar el efecto erosivo de la escorrentía superficial.
Effect of Magnesium Sulfate and Rhizosphere Microorganisms on the Growth and Biosynthesis of Cymbopogon nardus L. Essential Oil
Authors: Danata N.H. , Aini N. , Udayana C. , Setiawan A. 
Published: November 2024

Background: Citronella oil from Cymbopogon nardus L. is used in various fields, including health, industry and pharmaceuticals. Efforts to increase the content and quality of essential oils in this research were made with the application of magnesium sulfate. Rhizosphere microorganisms, which act as biological fertilizers, are applied to assist in the absorption of nutrients. This research aims to determine the interaction between the type of rhizosphere microorganisms and the dose of MgSO4 on growth, essential oil yield and essential oil content in C. nardus. Methods: The research was carried out from February to August 2023. The research used a randomized block design arranged factorially with three replications. The first factor is the type of rhizosphere microorganisms (without RM, PGPR and AMF) and the second factor is the MgSO4 fertilizer dose (0, 190, 285 and 280 kg ha-1). Result: Providing MgSO4 fertilizer can increase the growth and yield of essential oils of C. nardus. The application of PGPR and AMF can increase efficiency of MgSO4 fertilization. Treatment without administering rhizosphere microorganisms required a higher dose of MgSO4 compared to PGPR and AMF treatments. To increase growth variables and essential oil quality, treatment without rhizosphere microorganisms requires MgSO4 of 380 kg ha-1, while PGPR and AMF only require MgSO4 at a dose of 190-285 kg ha-1.
Morphological and Productivity Response of Chickpea (Cicer arietinum L.) to Nano Biofertilization
Authors: Abisankar M. Sri , Augustine R. , Manuel R. Isaac , Kumar S.M. Suresh 
Published: November 2024

Background: Chickpea productivity in the last decade has been declined due to improper management of inorganic and organic nutrient sources and it has been contended that the usual native soil rhizobial populations are insufficient/ineffective in N2 – fixation. Rhizobium based biofertilizers may substitute nitrogenous chemical fertilizers and provide a suitable way of achieving sustainable production. The effective use of exogeneous application of nano emulsion biofertilizer can enhance yield by reducing flower drop, regulating pod formation besides improving soil quality. In view of above consideration, the present investigation entitled “Morphological and productivity response of chickpea (Cicer arietinum L.) to nano biofertilization” was carried out. Methods: The field experiment was conducted on sandy clayey loam soil during two consecutive Rabi seasons of 2022-2023 and 2023-2024. The experiment was laid out in randomized complete block design (Factor) with three replications, assigning 45 treatments consisting of five soil applications (100% RDF; 100% RDF + FYM; 100% RDF + Vermicompost; 75% RDF + FYM; and 75% RDF + Vermicompost) as first factor and three foliar applications (Nano DAP; Nano Urea and Nano emulsion biofertilizer) as second factor treatments. Result: Application of Nano emulsion biofertilizer to chickpea variety (NBeG-49) at harvest had shown significant higher plant height (35.03 cm), dry matter production (3251.43 kg ha-1), leaf area index (0.90), crop growth rate (1.59 gm-2 day-1), relative growth rate (26.3 mg g-1 day-1), chlorophyll (SPAD value) (58.22), number of pods/plant (24.93), seed yield (1111.60 kg ha-1), straw yield (2501.10 kg ha-1) and nitrogen uptake (70.56 kg ha-1), phosphorus uptake (203.21 kg ha-1) and potassium uptake (54.30 kg ha-1).
Top Coal Weakening by Pulse Hydraulic Fracturing and Roof Cutting by Directional Hydraulic Fracturing for Control of Hanging Roof in the Face End of Fully Mechanized Top Coal Caving
Authors: Shao Luying , Huang Bingxiang , Zhao Xinglong , Li Haoze , Chen Shuliang 
Published: November 2024

Abstract
Due to the supporting effect of the coal pillar on the side of the roadway, there is often a problem of the top coal and roof in the working face end not collapsing in time. The single directional hydraulic fracturing method cannot directionally cut off the top coal of the working face end. To overcome the above shortcomings, this article first proposes a method of controlling top coal and roof in the working face end by pulse and directional hydraulic fracturing. The method of using pulse hydraulic fracturing to weaken the top coal and directional hydraulic fracturing to cut off the roof to induce rock pressure to break the coal is used to control the timely collapse of the top coal and roof in the working face end. When the vertical stress on the top coal is greater than the strength of the weakened top coal, the top coal and roof begin to collapse. The vertical displacement of the weakened top coal and the cut roof gradually decreases from low to high, and the caving top coal and roof finally fill the goaf. The maximum reduction in stress concentration of coal pillar is about 75%. Then, the principles for determining the parameters of this method were provided. Finally, the industrial experiment was conducted in the coal mine. The construction water pressure of the roof is between 30 and 40 MPa. The construction water pressure of top coal ranges from 8 to 16 MPa, with an amplitude of approximately 4 MPa. Directional crack is formed within an area of 3.3 m in the direction of the adjacent roof borehole. A crack network is formed within a 4 m area near the top coal borehole. After hydraulic fracturing, the top coal and roof in the working face end collapse with mining.
Specific Surface of Porous Materials
Authors: Kumar J. , Fatt I. 
Published: November 2024

The Kozeny-Carman equation
(Equation 1)
relates specific surface to the permeability and porosity of a porous medium. This equation involves the factor τ, known as Kozeny factor, which is hard to estimate and varies with the nature of the porous material.
An equation, based on experimental work, is presented here that relates the specific surface of an unconsolidated porous material to its permeability and porosity. Previous work reporting on Nuclear Magnetic Resonance techniques gave the following two relationships:
(Equation 2)
(Equation 3).
Therapeutic Potential of 6-Amino Flavone: A Novel Approach for Diabetes and Inflammation via TNF-α/ p-IRS Signaling Pathway in Albino Mice
Authors: Amin Zarnosh , Husn Mansoor , Fayaz Wajeeha , Shah Shahid Ali , Wadood Abdul 
Published: November 2024

Abstract

Diabetes, an alarming modern-day epidemic, imposes a substantial burden due to its rising incidence rate. Diabetes, in addition to its metabolic consequences, has emerged as a contributor to cognitive decline via a number of underlying processes, including neuroinflammation. Among the critical processes linked to diabetes, the release of pro-inflammatory cytokines has received a lot of attention. The present study aimed to investigate the potential of 6-amino flavone as an agent for treating Alloxan-induced diabetes mellitus and neuroinflammation in albino mice. The anti-diabetic and anti-neuroinflammatory effects were assessed through Y-maze, Morris water maze, and probe test in all four groups. The results indicated that the 6-amino flavone group showed a promising in-crease in short-term and long-term cognitive functions compared to the alloxan-induced group. Noticeably, the western blot analysis depicted that 6-amino flavone exerts antioxidant, anti-diabetic, and neuroprotective effects by inhibiting the p-IRS/TNF-α signaling pathway and enhancing the synapse performance via upregulation of SYP and PSD-95 proteins in the Allox-an-induced diabetes mellitus group. The findings of the present study infer that 6-amino flavone could be used as a potential therapeutic agent for treating diabetes complications and associated neuroinflammation.