bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endovascular Treatment of Various Aortic Pathologies: Review of the Latest Data and Technologies
Authors: Ohki Takao , Kanaoka Yuji , Maeda Koji 
Published: May 2018

AbstractThe technologies and innovations applicable to endovascular treatment for complex aortic pathologies have progressed rapidly over the last two decades. Although the initial outcomes of an endovascular aortic repair have been excellent, as long-term data became available, complications including endoleaks, endograft migration, and endograft infection have become apparent and are of concern. Previously, the indication for endovascular therapy was restricted to descending thoracic aortic aneurysms and abdominal aortic aneurysms. However, its indication has expanded along with the improvement of techniques and devices, and currently, it has become possible to treat pararenal aortic aneurysms and Crawford type 4 thoracoabdominal aortic aneurysm (TAAA) using the off-the-shelf devices. Additionally, custom-made devices allow for the treatment of arch or more extensive TAAAs. Endovascular treatment is applied not only to aneurysms but also to acute/chronic dissections. However, long-term outcomes are still unclear. This article provides an overview of available devices and the results of endovascular treatment for various aortic pathologies.
An N-of-1 Feasibility Study of Homeopathic Treatment for Fatigue in Patients Receiving Chemotherapy
Authors: Balon Jeffrey , Zhao Linlu , Seely Dugald , Brulé David 
Published: May 2018

Background Cancer-related fatigue has been described as a subjective feeling of physical, emotional, and/or cognitive tiredness. Homeopathy has been widely used to treat side effects of chemotherapy. The n-of-1 design is a single-patient trial method to study a clinical condition that is either short lived and reversible or is chronic and stable. The n-of-1 design requires a washout/reset period. The feasibility of performing an n-of-1 study in homeopathy has not previously been tested.
Methods A feasibility n-of-1 trial of individualized homeopathic treatment for fatigue in a single adult undergoing chemotherapy administered periodically was performed. For each matched pair of treatments, the participant was randomly allocated either placebo or verum for the period between treatments. For the subsequent treatment period, the opposite allocation was given. Participant and practitioner were blinded to the allocation. Ongoing conventional treatments were permitted. The ability to recruit and retain was monitored and changes in fatigue and quality of life were measured using two validated outcome measures.
Results Sixty-eight patients were assessed between February 2014 and February 2015. Four patients were eligible for the study and one consented to participate. The participant enrolled in the study for six cycles of chemotherapy and completed all treatment and outcome measures. There was no improvement under homeopathic treatment compared to placebo. There were multiple confounding events such as conventional medication changes and an adverse event unrelated to therapy.
Conclusion Adequate recruitment was not feasible in this setting. The n-of-1 study design is feasible in this population from the perspective of the ability to complete the trial. No conclusion on the efficacy of homeopathy for this individual can be made. It is unclear as to whether multiple treatments of chemotherapy would be an appropriate clinical situation in which to apply the n-of-1 trial methodology. Future studies should pilot adaptations to this study design.
Intravenous Acetaminophen May Be Associated with Reduced Odds of 30-Day Readmission after Total Knee Arthroplasty
Authors: Mont Michael , Lovelace Belinda , Pham An , Hansen Ryan , Chughtai Morad , Gwam Chukwuweike , Khlopas Anton , Barrington John 
Published: May 2018

AbstractThe purpose of this study was (1) to evaluate 30-day readmission rates in total knee arthroplasty (TKA) patients who either received intravenous (IV) or oral (PO) acetaminophen (APAP) perioperatively and (2) to extrapolate the potential annual cost savings on the national level. This was a review of 190,691 TKA recipients between the years 2012 and 2015 who received either IV (n = 56,475) or PO APAP (n = 134,216). All-cause readmissions that occurred between patient discharge and 30 days postdischarge were recorded. Continuous and categorical variables were evaluated using t-test and chi-square test, respectively. A logistic regression analysis was conducted to assess the effect of IV APAP on 30-day readmission. We also performed a literature review on 30-day readmission rates and risk prediction tools for TKA and correlated these with our findings. In addition, we extrapolated potential cost savings on the national level. The readmission rate was 0.04% in the IV and 0.14% in the PO APAP cohort (69% decreased risk; odds ratio = 0.31; 95% confidence interval = 0.20–0.47; p < 0.001). The readmission rate in this patient population appears to be markedly lower, when compared with previous reports. This reduction in readmissions may potentially result in $160 million savings per year. The use of IV APAP in TKA patients resulted in lower readmission rates, which may be valuable in clinical decision making by surgeons and health care administrators looking to lower costs of care.
TDABC Cost Analysis of Ocular Disorders in an Ophthalmology Emergency Department versus Urgent Care: Clinical Experience at Massachusetts Eye and Ear
Authors: Chou Jonathan , Shah Mahek , Watts Amy , Gardiner Matthew , Kaplan Robert , Miller Joan , Loewenstein John 
Published: May 2018

Purpose To perform a cost analysis comparison for managing common ocular disorders in an eye emergency department (ED) versus an urgent care setting using a time-driven activity-based cost model (TDABC) to assist physicians and staff in appropriate allocation of resources at their own institution.
Design Retrospective analysis.
Setting Massachusetts Eye and Ear (MEE) ED and Same-Day Services (SDS), which runs as an urgent care clinic.
Population Patients diagnosed with corneal abrasions, dry eyes, conjunctivitis, and styes were identified between April 2014 and August 2015 (n = 2,408 [ED], 26 [SDS]). We determined resources used in delivery of care, which included personnel, consumables, space capacity, and equipment. Costs were identified based on time the patient spent with each resource.
Main Outcome Average visit length and associated personal, space, equipment, and consumable costs.
Results Average visit length was 196 and 53 minutes, respectively, primarily due to longer wait times in the ED. Personnel and space costs were higher in the ED compared with SDS ($68.92 vs. $51.37 and $24.44 vs. $12.86, respectively). This led to an overall higher total resource cost for patients seen in the ED compared with SDS ($108.41 vs. $81.53, respectively).
Conclusion For common ocular disorders, total SDS costs were 25% less than ED costs at MEE primarily due to personnel and space utilization. Treating patients with nonemergent ocular problems outside the ED can lead to shorter visit times for patients as well as lower overall costs.
The Efficacy of Neutral Position Beractant Administration in Neonates
Authors: Barnes Kelsi , Beckett Robert , Rice Melissa , Kovey Karen 
Published: May 2018

Objective The objective was to compare the efficacy and adverse effects of beractant administration in neonates via a single aliquot in a neutral position versus positioning the neonates on their left then right side and two aliquots administration.
Study Design This was a retrospective cohort chart review of neonates who were diagnosed with respiratory distress syndrome and received beractant during two 15-month periods between 2013 and 2015 and 2015 and 2016 to compare the change in the fraction of inspired oxygen (FiO2) 1 hour after beractant administration.
Results There were no differences in FiO2 1 hour after beractant between groups (p = 0.617). Adverse events and other comorbidities did not differ between the groups.
Conclusion Changing administration of beractant from two aliquots and positions to a neutral position resulted in no significant change in FiO2 and may be considered as an option for administration in neonates.
Hepatoprotective Potential of Elsholtzia densa Against Acute and Chronic Models of Liver Damage in Wistar Rats
Authors: Zargar Ovais , Bashir Rohina , Ganie Showkat , Masood Akbar , Zargar Mohammad , Hamid Rabia 
Published: May 2018

AbstractThe aim of the present study was to evaluate the hepatoprotective activity of methanolic extract of Elsholtzia densa against experimentally induced acute (CCl4) and chronic (paracetamol) liver injury in albino wistar rats. Activity was measured by monitoring the serum levels of ALT, ALP AST and LDH, total protein levels, bilirubin and albumin. The results of the CCl4 and paracetamol-induced liver toxicity experiments showed that the rats treated with the methanolic extract of Elsholtzia densa exhibited a significant decrease in biochemical parameters as well as the proteins, which were all elevated in the CCl4 and paracetamol group. The extract at a concentration of 300 mg/kg body wt. showed a significant decline (P≤0.05) in the levels of AST, ALT, ALP and LDH to 69.50±2.23IU/L, 60.01±2.25IU/L,46.20±2.24 IU/L and 150.21±5.68IU/L in CCl4 injected animals and 51.12±2.20 IU/L,49.15±3.25 IU/L, 44.12±2.56 IU/L and 125.15±4.45 IU/L in paracetamol-treated animals when compared to the control group. The activities of tissue antioxidants GSH, GPx, GR, GST and CAT was significantly (P≤0.05) restored in dose dependent manner in animals treated with extracts as with acute and chronic hepatotoxic models. The current study confirmed the hepatoprotective effect of methanolic extract of Elsholtzia densa against the model hepatotoxicant CCl4 and paracetamol.
11.361 sports injuries in a 15-year survey of a Level I emergency trauma department reveal different severe injury types in the 6 most common team sports
Authors: Krutsch Werner , Krutsch Volker , Hilber Franz , Pfeifer Christian , Baumann Florian , Weber Johannes , Schmitz Paul , Kerschbaum Maximilian , Nerlich Michael , Angele Peter 
Published: May 2018

Abstract
Introduction Severe sports-related injuries are a common affliction treated in Level I trauma departments. Detailed knowledge on injury characteristics from different medical settings is essential to improve the development of injury prevention strategies in different team sports.
Methods Team sport injuries were retrospectively analysed in a Level I trauma department registry over 15 years. Injury and treatment data were compared with regard to competition and training exposure. Injury data such as “time of visitation”, “type of injury”, “multiple injured body regions” and “immediate hospitalisation” helped to define the severity level of each team sports injury.
Results At the Level I trauma department, 11.361 sports-related injuries were seen over 15 years, of which 34.0 % were sustained during team sports. Soccer injuries were the most common injuries of all team sports (71.4 %). The lower extremity was the most affected body region overall, followed by the upper extremity. Head injuries were mainly seen in Ice hockey and American football and concussion additionally frequently in team handball. Slight injuries like sprains or contusions occurred most frequently in all team sports. In soccer and team handball, injuries sustained in competition were significantly more severe (p < 0.001) than those sustained in practice.Volleyball and basketball had a trend to higher rate of severe injuries sustained during practice sessions.
Conclusion Depending on the specific injury profile of each team sports, injury prevention strategies should address competitive as well as training situations, whichmay need different strategies.
Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a)
Authors: Singh Digvijay , Mallon John , Poddar Anustup , Wang Yanbo , Tippana Ramreddy , Yang Olivia , Bailey Scott , Ha Taekjip 
Published: May 2018

Significance
Adaptive immunity against foreign DNA elements in microbes, conferred by their CRISPR systems, has been repurposed for wide-ranging genome-engineering applications. The CRISPR-Cas9 system has been the most widely used system. But to overcome some of its major limitations, the search for novel CRISPR enzymes has been a significant area of interest. One such search led to the discovery of CRISPR-Cpf1 systems. We used single-molecule fluorescence analysis and biochemical assays to characterize the kinetics, specificity, and mechanism of Cpf1’s DNA interrogation, cleavage, and cleavage-product release. Some major differences from Cas9 were observed which will help the use of Cpf1 in areas outside the realm of Cas9 and effectively broaden the scope of CRISPR-based applications.
Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine
Authors: Lei Weiwei , Ren Wenwen , Ohmoto Makoto , Urban Joseph F. , Matsumoto Ichiro , Margolskee Robert F. , Jiang Peihua 
Published: May 2018

Significance
Tuft cells in the intestine are known to act as sentinels for infectious agents [e.g., helminths (worms) and bacterial microbiota] and express taste-signaling elements. In this work, the G protein-coupled receptor Sucnr1 was shown to be expressed specifically in tuft cells but not in other intestinal epithelial cells. Dietary succinate and perturbations in the microbiota activate tuft cells, and subsequently type 2 immunity, via tuft cell-expressed Sucnr1. Modulating this pathway using dietary succinate or specific Sucnr1 agonists may be a strategy for fighting bacterial and parasitic infections or other type 2 immune-related metabolic disorders such as obesity.
Genos, sex, gender and genre
Authors: Sandford Stella 
Published: May 2018

Abstract
This chapter discusses translators’ efforts to render the grammatical gender of Plato’s Greek in passages of the Republic, and to translate his terms noting differences between men and women with terms associated with the identity-defining concepts of sex and gender. It argues that the translation of genos as “sex” reveals less about the source text than about the role of the concept of sex in the translating culture. A discussion of a similar controversy in contemporary translation shows how debates over the French translation of “gender” as genre are embroiled in issues of national identity. The chapter demonstrates how translation and its analysis may simultaneously express and contest cultural assumptions about sex and gender.
Lithuanian literature in English
Authors: Vaičenonienė Jurgita 
Published: May 2018

Abstract
The purpose of this article is to compare two translations into English of the Lithuanian short story “The Bread Eaters” (1975) written by Romualdas Granauskas. Corpus-based methods are used in order to detect the stylistically and culturally important lexical features of the source text and to evaluate their translations. Specifically, global statistics, keywords, and parallel concordances of the selected lexical items of the original and translations are compared. I argue that a corpus-based analysis of the original and translated texts, used alongside their manual assessment, may help to objectively identify specific features of the Key Cultural Texts, evaluate their retention in translations, and guarantee more accurate target representation of the encoded cultural concepts and ideas of the source text.
The image of H. C. Andersen’s tales in China (1909–1925)
Authors: Li Wenjie 
Published: May 2018

Abstract
Using early translations and interpretations (1909–1925) of H. C. Andersen’s tales in China as an example of Key Cultural Texts in translation, this study will examine the major elements that influenced the Andersen translations and interpretations in the period from 1909, when Andersen’s tales were introduced to the Chinese readership, to 1925, when the first surge of translation occurred on the occasion of H. C. Andersen’s 150th birthday. I discuss the socio-historical environment, the purposes of introducing and translating this oeuvre, the human elements involved. I introduce and explain the concept of the “translated image” and discuss why certain translated images have been key to the Chinese understanding of Andersen’s works and Andersen the writer until the present day.
The immigration of key cultural icons
Authors: Pan Hanting 
Published: May 2018

Abstract
The Church is a key icon of Christianity. Journeying to disseminate Christianity eastward, many European missionaries chose Macao as their first stop in China, and built churches for religious practice. To have the new religion recognised by local people, the foreign church names were translated into Chinese. This article surveys church name translation in Macao from the 16th to the 20th century, identifying and comparing the linguistic patterns of original and translated names and the associated translation strategies. I argue that translation plays a crucial role in integrating the immigrated culture into the host culture. In addition, translations of church names reflect social changes and social relationships within the host society.
Evaluating grammaticalization and constructional accounts
Authors: Enghels Renata , Comer Marie 
Published: May 2018

Abstract
This article explores the historical development of the inchoative construction in Spanish with the put verbs poner and meter filling the auxiliary verb slot. Previous studies have focused mainly on the syntactic and semantic processes through which full lexical put verbs come to fulfil an auxiliary role in the inchoative periphrasis. The analysis presented in this article aims at going beyond this traditional, grammaticalization account, and examines whether a constructional approach offers a more nuanced account of the empirical data. The main objective is to verify the extent to which different structural patterns of the inchoative construction have given rise to a general constructional schema.
A centering theoretic account for the changing usage of anaphoric expressions in the history of German
Authors: Speyer Augustin 
Published: May 2018

The Centering status of a referent and the coherence relation of the discourse unit in which the referent is used are potential factors for anaphor resolution. In Old High German, as exemplified with Otfrid’s Evangelienbuch, there is a strong tendency for this generalisation – Backward looking centers in Continue relations tend to be realised by personal pronouns, in Retain and Shift relations, they tend to be realised by demonstrative pronouns – but it is far from categorical. There are even blatant violations of generalizations that hold for Modern German, so the importance of Centering as a factor is higher today than in Old High German. In Early New High German of the 14th century, anaphora resolution was sensitive to Centering. The hierarchical structure of a text played a bigger role, as adjacency was defined not strictly linearly, but with respect to discourse units on the same hierarchical level.
What is a Narration – and why does it matter?
Authors: Zeman Sonja 
Published: May 2018

Despite the increasing interest in textual structure and the specific use of linguistic means in narratives, the concept of Narration has so far not been an issue of theoretical concern within linguistics but has rather been used than defined or problematized. In this respect, the chapter takes a closer look at the concept of Narration itself. The starting point is the basic assumption that the analysis of Free Indirect Discourse (FID) – a phenomenon which seems to be restricted to Narration only – will offer crucial insights with respect to characteristics of the underlying narrative structure when read “against the grain”. In this regard, the alignment of formal approaches of context shift and cognitive approaches of perspectivization leads to the conclusion that the narratological differentiation between narrator and character can be seen as a projection of the grammatical differentiation between speaker vs. observer, which is reflected on the different linguistic levels in a recursive manner. Consequently, I argue that the complex unfolding of different layers of discourse allows for poly-perspectival resp. metarepresentational effects on the textual macro-structure and hence constitutes a core characteristic of Narration. Against this background, the proposed model is not only able to align micro- and macro-structural accounts of Narration but also allows for a new perspective on the specific use of grammatical means in narrative discourse. In this respect, the paper argues that Narration does indeed matter for linguistics.
Pragmatic development in the instructed context
Authors: Nguyen Thi Thuy Minh 
Published: May 2018

Abstract
This article reports an eight-month investigation into the long-term impact of explicit instruction on the learnability of different aspects of email requests by a group of Vietnamese university students. Two intact classes were randomly assigned to the treatment (N = 13) and control conditions (N = 19). Over a four-week period, the treatment group received six hours of instruction which comprised consciousness-raising, meta-pragmatic explanation, repeated output practice and teacher feedback. The control group, on the other hand, only followed the usual syllabus. Results of the study indicate that the treatment group obtained significantly greater pre-to-posttest gains than the control group, and that their improvement was retained by the time of the eight-month delayed post-test. Despite the learners’ overall progress, however, it was also found that different aspects of their performance appeared to respond differently to instruction. The article supports the need for instruction of email politeness and discusses implications for future pedagogy and research.
Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression
Authors: Clos‐Garcia Marc , Loizaga‐Iriarte Ana , Zuñiga‐Garcia Patricia , Sánchez‐Mosquera Pilar , Rosa Cortazar Ana , González Esperanza , Torrano Verónica , Alonso Cristina , Pérez‐Cormenzana Miriam , Ugalde‐Olano Aitziber , Lacasa‐Viscasillas Isabel , Castro Azucena , Royo Felix , Unda Miguel , Carracedo Arkaitz , Falcón‐Pérez Juan M. 
Published: May 2018

ABSTRACTUrine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have previously identified proteins and RNAs with differential abundance in urinary EVs from prostate cancer (PCa) patients compared to benign prostate hyperplasia (BPH). Here, we focused on the analysis of the metabolites contained in urinary EVs collected from patients with PCa and BPH. Targeted metabolomics analysis of EVs was performed by ultra‐high‐performance liquid chromatography–mass spectrometry. The correlation between metabolites and clinical parameters was studied, and metabolites with differential abundance in PCa urinary EVs were detected and mapped into cellular pathways. We detected 248 metabolites belonging to different chemical families including amino acids and various lipid species. Among these metabolites, 76 exhibited significant differential abundance between PCa and BPH. Interestingly, urine EVs recapitulated many of the metabolic alterations reported in PCa, including phosphathidylcholines, acyl carnitines, citrate and kynurenine. Importantly, we found elevated levels of the steroid hormone, 3beta‐hydroxyandros‐5‐en‐17‐one‐3‐sulphate (dehydroepiandrosterone sulphate) in PCa urinary EVs, in line with the potential elevation of androgen synthesis in this type of cancer. This work supports urinary EVs as a non‐invasive source to infer metabolic changes in PCa.