bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly acidic pH values of carbonated sweet drinks, fruit juices, mineral waters and unregulated fluoride levels in oral care products and drinks in India: a public health concern
Authors: Chowdhury CR , Shahnawaz K , Kumari P D , Chowdhury A , Gootveld M , Lynch E 
Published: July 2018

Purpose: The objective of this study was to quantify and assess the concentrations of fluoride in commonly used oral care products, fruit juices, bottled waters, soft drinks, favoured bottled milk and milkshakes and to determine the pH of carbonated sweet drinks and drinks marketed in India. Materials and Methods: Various commercial brands of dentifrices, toothpowders, mouthwashes, bottled waters, sweet carbonated drinks and fruit juices were collected randomly from different outlets in Mangalore city, Karnataka, India. A fluoride ion–selective electrode was employed to estimate the fluoride concentrations. A standardised pH meter was used to detect pH in the drinks. Results: The fluoride level in toothpastes ranged between 96 and 1397 mg/l, whereas in toothpowder the fluoride content ranged from 35 to 1380 mg/l and mouthwash fluoride concentrations varied from 6 to 228 mg/l. The fluoride level in bottled waters ranged between 0.10 and 0.12 mg/l, and that in fruit juices between 0.09 and 0.21 mg/l. Most of the carbonated sweet drinks and fruit juices had highly acidic pH values which ranged between 2.62 and 4.26. Conclusion: Of the wide variety of dentifrices and toothpowders available in India, most brands do not indicate the fluoride levels on their packaging or inserts. Similarly, the unregulated acidic pH values of carbonated sweet drinks are not only potentially contributing to non-carious tooth loss (enamel erosion and dentine erosion), but are also a contributing factor to the weight gain observed in Indian adolescents.
Classification, microbiology and treatment of diabetic foot infections
Authors: Ghotaslou Reza , Memar Mohammad Yousef , Alizadeh Naser 
Published: July 2018

Diabetic foot ulcers (DFUs) are a common complication of type-1 and type-2 diabetes. About 10–15% of patients with diabetes develop foot ulcers. A validated foot ulcer classification system that will support the development of treatment strategis is necessary for clinicians managing DFUs. More than 10 classification systems have been described by researchers. Another important aspect of the management of DFUs is the proper identification of causative pathogens that trigger infections. While conventional diagnostic methods, such as swabs, cultures and biopsies are more widely used, novel molecular techniques have been exploring bacterial identification and quantification. Knowledge of the microbial aetiologies in diabetic foot infections, and understanding of antibiotic resistance, is critical for the effective management and treatment of these infected wounds. Initial antibiotic regimens are usually selected empirically. A set of common principles may help avoid selecting either an unnecessarily broad or inappropriately narrow antibiotic treatment regimen. In this review we provide a comprehensive summary and description of classification systems of diabetic foot infections, and a comprehensive discussion of microbiology.
Neurological perception and sound-based creativity in post-biological realities: Recontextualizing reflective practice for technoetic environments
Authors: Cross Tiernan 
Published: July 2018

Abstract
We currently exist in a post-biological age. Mixed-realities shape the way in which we live modern life; half in physical form, half in a hyper-mediated virtual environment of network protocols. This article discusses network-based impacts on neurological navigation and the ways in which the human auditory cortex is developing through conjuncture with post-biological combinations of sound. In doing so, it examines the capacity of the human brain in decoding and understanding the abundance of sound in confluent, variegated realms of existence and how such increased perceptions expand consciousness and, in turn, affect sonic creativity as a somewhat mimicry or response to our immediate auditory environments. Conclusively, it will be argued that the exploration of sound-based creativity can be reinterpreted for post-biological spaces, taking particular aim at the reflective approaches of musique concrète and how such technologically infused ideas can be transformed and recontextualized to match the power and capacity of today’s hybrid environments of occupancy.
On delight: Thoughts for tomorrow
Authors: Westermann Claudia 
Published: July 2018

Abstract
The article introduces the problematics of the classical two-valued logic on which Western thought is generally based, outlining that under the conditions of its logical assumptions the subject I is situated in a world that it cannot address. In this context, the article outlines a short history of cybernetics and the shift from first- to second-order cybernetics. The basic principles of Gordon Pask’s 1976 Conversation Theory are introduced. It is argued that this second-order theory grants agency to others through a re-conception of living beings as You logically transcending the I. The key principles of Conversation Theory are set in relation to the poetic forms of discourse that played a key role in art as well as philosophical thinking in China in the past. Second-order thinking, the article argues, is essentially poetic. It foregoes prediction in favour of the potentiality of encountering tomorrow’s delights.
Real-time? Reframing temporal consciousness in time-based and interactive media
Authors: Buchanan Andrew 
Published: July 2018

Abstract
The experience of time and temporally extended events is a fundamental property of mind, and of time-based media arts. In dealing with properties of time, does the operational logic of contemporary media production tools cohere with philosophical views on the experience of time? This article considers a range of views on the phenomenal experience of time as they relate to the production of time-based media. Embedded within our production technologies, the artist is faced with a new philosophical instrument: the production timeline. The timeline utility in most time-based media software (and non-digital precursors) adopts the cinematic model as its operating metaphor; a series of frames, assembled one after the other in sequence. But the timeline brings new temporal complications such as reversibility, hierarchy and modifiability. The timeline also contorts time into a spatialized dimension, represented as a linear vector within the software interface. Automatic adoption of the linear timeline and the frame as the base unit of temporal thinking is problematic. J. M. E. McTaggart’s argument for the unreality of time based on contradictions within a range of possible temporal modal logics is compared with approaches to animation and editing software, and also interactive media software and their unique approach to time as potential events is considered.
An astonishingly intricate architecture: Visual Music of the Brain and Mind
Authors: Trickett Terry 
Published: July 2018

Abstract
The overarching guiding principle of Alan Turing’s work was directed towards modelling the human mind as a machine. It is extraordinary that Turing introduced, in his early papers, ideas that are only now beginning to be investigated. Throughout his life, he considered conjectures to be of great importance because they suggest useful lines of research. In my own conjecture, I am asking the question: what is the brain’s geometry? Can it ever be unravelled, or does its complexity defy any form of visual representation? Recent research reveals that the detailed workings of the brain take place in a ‘global workspace’, where conscious contents appear to be disseminated globally to a great multitude of networks throughout the brain that are unconscious. During conscious tasks, neurons contributing to the global workspace enter into a coherent activation pattern by being tightly connected through long axons. Is it possible, therefore, that my proposed geometric pattern (an Islamic latticework) can be envisaged as a useful means of interconnecting multiple long axons in a unified global workspace dedicated to conscious thought? I share and communicate my idea through a process that combines visual imagery with musical performance (i.e. visual music). It is a method that can assist in clarifying concepts that might otherwise remain elusive or esoteric.
Performing Hypo-Linguistics
Authors: Stoyanova Minka , SoYoung Lisa Park 
Published: July 2018

Abstract
Language is the original technological prosthesis mediating all transfer of human cognition. The relationships between language, communication and cognition have long been the subject of scientific, philosophic and linguistic inquiry. However, it is through contemporary advancements in neuroscience that we now have unprecedented access to the inner workings of the human brain. Particularly, consumer grade neural scanning technologies like the Muse headset allow non-scientists to view, manipulate and draw conclusions from data generated by their own neural processes. Hence, artists Minka Stoyanova and Lisa Park SoYoung have created an artistic experimental system that utilizes these technologies to address the possibility of communication beyond the confines of linguistic signification. Performing Hypo-Linguistics uses Muse brain sensors to create an abstract audio-visual communication system and feedback loop. Through the visualization and sonification of their respective brain data, these artists perform communication that is both outside of conscious control and beyond sign-based systems of linguistic representation. In this article, we discuss the philosophic and scientific groundwork that supports the creation of this system; our processes of sonification and visualization of the Muse-generated brain data (including the modes by which we actively avoided signification and expected technological aesthetics of data representation); and the outcomes of the performances or the realized interaction between the performers. As deep-learning algorithms become increasingly able to teach computers to mimic human language, it becomes ever more apparent that language is not, in fact, the purview of the human, but only one technological mode invented to facilitate the transfer of information. As with all systems of communication, noise is introduced in this process of transfer. This artistic research seeks to highlight that reality while considering the potentials for alternative forms of technologically mediated communication beyond linguistic signification and below the level of consciousness.
Virtual reality and human consciousness: The use of immersive environments in delirium therapy
Authors: Suvajdzic Marko , Bihorac Azra , Rashidi Parisa , Ong Triton , Applebaum Joel 
Published: July 2018

Abstract
Immersive virtual environments can produce a state of behaviour referred to as ‘presence’, during which the individual responds to the virtual environment as if it were real. Presence can be arranged to scientifically evaluate and affect our consciousness within a controlled virtual environment. This phenomenon makes the use of virtual environments amenable to existing and in-development forms of therapy for various conditions. Delirium in the intensive care unit (ICU) is one such condition for which virtual reality (VR) technology has not been evaluated to date. We are currently assessing the feasibility and utility of a delirium prevention and treatment system, which implements VR to improve quality of sleep, reduce pain, lower usage of sedatives, and stimulate cognition. The proposed system will consist of 3-axis wearable accelerometers, 6-DOF position trackers, a VR system and apps designed to promote sleep quality and mindfulness. Our a priori hypothesis is that our VR therapy system would lower the occurrence of delirium in patients admitted to ICUs.
From the ego to the alter ego – interacting with the self image through Neuro Mirror
Authors: Sommerer Christa , Mignonneau Laurent 
Published: July 2018

Abstract
In this article, we introduce our interactive art installation Neuro Mirror that was developed in 2017 for the Cybernetic Consciousness [?] exhibition that was held in 2017 at the ITAU Cultural in Sao Paulo. This artwork enables participants to interact with their own images and those of their alter egos with the help of digital mirrors. The installation consists of three screens. The middle one shows a live image of the participant that is somewhat distorted. The one on the left side also displays an image of the interacting person, but with a time delay of a few seconds. On the right screen, however, another person is shown – a young man, who is acting and moving his head. In fact, this person is programmed to be an avatar or an alter ego who reacts to the participant. He ‘learns’ new behaviours by observing and imitating the participant and reacts accordingly. A neural network programme was developed to enable him to predict the participant’s next actions from his previous ones.
Chinese characters and the spirit of place in China
Authors: Siqi Deng 
Published: July 2018

Abstract
Writing, or calligraphy, in China is strongly influenced by ancient techniques of making art. Chinese characters have evolved from the patterns of bronze drawings, and China’s earliest hieroglyphs usually retain the traces of their origin in paintings. These paintings usually recorded daily life, and the related Chinese characters have evolved from these with general, simplified and abstract features. The composition that makes Chinese characters is a manifestation of ancient Chinese philosophy, of which Confucianism, Taoism and Buddhism are the three key strands. They have affected Chinese culture and aesthetics in all dynasties.
Chinese philosophy emphasizes the integration of individuals in their surrounding environment. The art of ancient China consequently combines skills that relate to the artificial, or constructed, and to natural patterns. Chinese characters make a perfect example of this. The article/presentation will outline the research that I have so far undertaken on the relation between Chinese calligraphy and architectural space, between writing and constructing environments. It will also present some experimental design research that aims at developing from the above-mentioned basic research new architectural typologies that are contemporary, resonant and sensitive to the Chinese context.
Humán inzulinról glargininzulin-alapú bázis-bolus kezelésre váltott betegek glykaemiás állapotának javulása a váltás után
Authors: Nagy Erzsébet , Kovács Gábor 
Published: July 2018

Abstract: Introduction: The effectiveness of human and analogue insulins is similar but the latter have more advantageous pharmacokinetic features, leading to an improvement in hypoglycaemia and come closer to achieving the physiologic insulin profile. Aim: To demonstrate that switching from a human basal-bolus insulin treatment to an insulin glargine-based basal-bolus regimen can achieve a better glycaemic control. Method: This 3-month prospective, non-interventional study, including a 12-month retrospective data collection phase, enrolled patients who were switched to the insulin glargine- – 100 U/mL – based basal-bolus treatment at the time of enrolment if they were inadequately controlled and had at least one additional HbA1c result in the 12 months before the switch. Of 1513 patients 1181 had the data that were needed for the efficacy analysis. Results: The mean age of the efficacy population was 58.3 years and 48.1% were male. Their mean HbA1c levels remained unchanged in the year before the switch: it was 8.8 ± 1.4% at 12 months prior to the switch and 8.8 ± 1.2% at the switch, but decreased significantly to 7.7 ± 1.0% (p<0.001) after 3 months. Between the baseline and 3 months, the fasting blood glucose and the postprandial blood glucose improved significantly (from 10.0 ± 3.2 mmol/L to 7.4 ± 1.9 mmol/L, p<0.001 and from 11.1 ± 2.8 mmol/L to 8.8 ± 1.7 mmol/L, p<0.001, respectively). Insulin doses were increased both before and after the switch. Conclusions: Switch to an insulin glargine-based basal-bolus regimen could achieve a significant improvement in the glycaemic control in patients who were inadequately controlled prior to the switch. Orv Hetil. 2018; 159(29): 1201–1207.
A megfelelő szájegészség megvédhet a kalciumcsatorna-blokkoló készítmények okozta gingivahyperplasia kialakulásától
Authors: Bán Ágnes , Pintér Erika , Kun József 
Published: July 2018

Abstract: Cardiovascular diseases including hypertension affect 40% of the adult population in Hungary. Calcium channel blockers are frequently prescribed for the treatment of hypertension either in monotherapy or in fixed-combination therapy. Their main effect is vasodilatation with gingival hyperplasia as a side effect. Our aim is to draw our colleagues’ attention to the practical importance of the fact that calcium channel blocker-induced gingival hyperplasia correlates closely with the dental status and the quantity of plaque on the surface of teeth and dental implants. Once established, gingival hyperplasia makes it more difficult for the patient to maintain individual tooth cleaning and increases plaque formation. Thus proliferation of Gram-negative bacteria is enabled in the plaque which promotes gingival overgrowth and can pose a risk factor for further cardiovascular diseases. If proper individual oral hygiene and professional interventions are carried out, healthy and hyperplasia-free gingival state can be sustained in the long term in most cases, even with calcium channel blocker therapy. In order to protect patients’ oral health, a closer cooperation of internists and dentists would be desirable. Orv Hetil. 2018; 159(29): 1183–1187.
EKG-gyöngyszem: tranziens Q-hullám myocardialis infarctusban
Authors: Tomcsányi János 
Published: July 2018

Abstract: A case of ST-segment elevation myocardial infarction (STEMI) is presented with pathologic transient Q-waves in the precordial leads disappearing after percutaneous coronary intervention (PCI). Orv Hetil. 2018; 159(29): 1208–1209.
A beállítási biztonsági margó nagyságának meghatározása fej-nyak daganatok 2D-2D és 3D képvezérelt intenzitásmodulált sugárkezelése esetén
Authors: Kovács Péter , Szita Evelin , Schvarcz Kitti , Kamu Szabolcs , Kalincsák Judit , Kovács Árpád , Repa Imre , Hadjiev Janaki 
Published: July 2018

Abstract: Introduction: Image-guided intensity-modulated radiation therapy is essential for oncology treatment of head-and-neck cancer patients. Aim: MV-kV and CBCT modalities were compared in case of IGRT treatment for head-and-neck cancer patients. Setup error, setup margin (SM), imaging and evaluation times and imaging doses were analyzed. Method: Eight patients’ elective treatment was evaluated, 66 orthogonal MV-kV images and 66 CBCT series were acquired. Setup error measurement was based on bony manual image registration in three translational directions. Normality test and F-test were performed followed by the comparison with independent-samples T-test (p<0,05). The necessary target volume setup margin was calculated based on Van Herk’s equation. Imaging time and setup error determination time were measured. Imaging doses were estimated based on the literature. Results: No statistically significant difference was found between setup errors determined by MV-kV and CBCT (VRT: 0.5 mm, SD = 1.9 vs. 0.4 mm, SD = 2.1, p = 0.371; LNG: 0.2 mm, SD = 2.2 vs. –0.1 mm, SD = 2.2, p = 0.188; LAT: 0.2 mm, SD = 2.2 vs. 0.3 mm, SD = 2.1, p = 0.41). SM values were: VRT: 2.7 mm vs. 2.5 mm; LNG: 2.1 mm vs. 1.3 mm; LAT: 2.2 mm vs. 2.3 mm. Mean imaging time was 0.65 min (MV-kV) vs. 2.29 min (CBCT). Mean setup error determination time was 2.41 min for both modalities. Estimated imaging doses were 6.88 mGy (MV-kV) vs. 17.2 mGy (CBCT) per fraction. Conclusion: The bony anatomy derived image registration based translational setup error determination results in similar values either by MV-kV or by CBCT. Using 3 mm setup margin in all the directions might be adequate. Imaging time is less by MV-kV, significant difference in imaging doses did not appear. Using CBCT is generally suggested. MV-kV might be an alternative in case of need for shortened imaging time. Orv Hetil. 2018; 159(29): 1193–1200.
A pubertas fejlődését szabályozó neuroendokrin mechanizmusok. Irodalmi áttekintés
Authors: Ságodi László , Sólyom Enikő , Kiss-Tóth Emőke 
Published: July 2018

Abstract: Puberty is the stage of development in human life, when the hypothalamus–hypophysis–gonad axis is re-activated after quiescence. Humanity has long been concerned with the idea of exogenous and endogenous factors and mechanisms that influence the temporal course of puberty neuroendocrine events. Recent discoveries have helped to understand the functioning of the neuroendocrine system. It has been clarified that kisspeptin plays a key role in puberty and regulation of fertility. However, in the function of the gonadotropin-releasing hormone (GnRH) pulse secretion, besides kisspeptin, neurokinin B, dynorphin neurons other positive and negative signals are involved, guiding the release of hormones of hypophysis gonadotropin. The knowledge of these nerves further enhanced the understanding of GnRH pulsation modulation by endocrine, metabolic and environmental impacts. The authors point out the risk of endocrine disruptors in the physiological course of puberty. The aim of the review is to provide a comprehensive picture of the research results of the physiology of kisspeptin, as the manipulation of kisspeptin signaling has the potential for novel therapies in patients with pathologically low or high luteinizing hormone (LH) pulsatility. Orv Hetil. 2018; 159(29): 1175–1182.
A Combined Computer-Aided Approach to Drive the Identification of Potential Epitopes in Protein Therapeutics
Authors: Galvão da Silva Bárbara Athayde Vaz , Chudzinski-Tavassi Ana Marisa , Pasqualoto Kerly Fernanda Mesquita 
Published: July 2018

Background: The identification of fragment sequences, or motifs, within a therapeutic protein that may elicit an immune response when processed by T-cells can be provided by computer-aided approaches. Immunogenicity is a significant problem associated with protein therapeutics and should be investigated in the early stage of protein-based drug development to avoid treatment resistance and potentially life-threatening immune responses. Purpose: To provide a combined computer-aided protocol for investigating the immunogenic profile of a recombinant Kunitz-type inhibitor, which has been reported as promising antitumor agent by our research group. Methods: The combination of databases searching (IEDB and SYFPEITHI) and molecular docking simulations was exploited, herein. This combined protocol has allowed the identification of potential epitopes before in vitro/in vivo evaluation. Predictors of human proteasome cleavage transport and major histocompatibility complex (MHC) binding were considered as overall score assigning the corresponding intrinsic potential of being a T cell epitope to each fragment sequence. The peptides or motifs better classified in the two databases were docked into the three-dimensional (3D) structure of MHC (class I and II) complex to verify the calculated binding affinity. The binding interactions regarding the molecular recognition process by T-cells were also exploited through the MHC:ligand:T-cell complexes. Results: Regarding the Kunitz-type sequence, four motifs were identified as potentially epitopes for MHC-I and three motifs were found for MHC-II. But, those motifs were classified as moderately immunogenic. Final remarks: The combined computer-aided protocol has significantly reduced the number of potential epitopes to be considered for further analysis and could be useful to identify immunogenic fragments (high, moderate and low) in protein pharmaceutics before in vitro/in vivo experimentation.