bluuebunny/crossref_metadata_2025_split huggingface dataset:
Language Sample Practices With Children Who Are Deaf and Hard of Hearing
Authors: Blaiser Kristina M. , Shannahan Megan A. 
Published: October 2018

Purpose
In this study, we aimed to identify common language sample practices of professionals who work with children who are Deaf/hard of hearing (DHH) who use listening and spoken language as a means to better understand why and how language sampling can be utilized by speech-language pathologists serving this population.

Method
An electronic questionnaire was disseminated to professionals who serve children who are DHH and use listening and spoken language in the United States. Participant responses were coded in an Excel file and checked for completeness. Descriptive statistics were used to analyze trends.

Results
A total of 168 participants participated in the survey. A majority of participants reported that they use language sampling as a part of their intervention when working with children who are DHH. However, approximately half of participants reported using norm-referenced testing most often when evaluating language of children who are DHH, regardless of the fact that they felt that language samples were more sensitive in identifying the errors of children who are DHH. Participants reported using language samples to monitor progress and set goals for clients. Participants rarely used language samples for eligibility and interprofessional collaboration.

Conclusions
Language samples offer a unique way to examine a child's language development that norm-referenced assessments are not sensitive enough to detect, particularly for children who are DHH. This offers insights into current practice and implications for the development of a more clearly defined language sample protocol to guide practices in the use of language samples with children who are DHH and use listening and spoken language.
Optimizing asteroid orbit computation forGaiawith normal points
Authors: Fedorets Grigori , Muinonen Karri , Pauwels Thierry , Granvik Mikael , Tanga Paolo , Virtanen Jenni , Berthier Jérôme , Carry Benoit , David Pedro , Dell’Oro Aldo , Mignard François , Petit Jean-Marc , Spoto Federica , Thuillot William 
Published: October 2018

Context.In addition to the systematic observations of known solar-system objects (SSOs), a continuous processing of new discoveries requiring fast responses is implemented as the short-term processing ofGaiaSSO observations, providing alerts for ground-based follow-up observers. The common independent observation approach for the purposes of orbit computation has led to unrealistically large ephemeris prediction uncertainties when processing realGaiadata.Aims.We aim to provide ground-based observers with a cloud of sky positions that is shrunk to a fraction of the previously expected search area by making use of the characteristic features ofGaiaastrometry. This enhances the efficiency ofGaiaSSO follow-up network and leads to an increased rate of asteroid discoveries with reasonably constrained orbits with the help of ground-based follow-up observations ofGaiaasteroids.Methods.We took advantage of the separation of positional errors ofGaiaSSO observations into a random and systematic component. We treated theGaiaobservations in an alternative way by collapsing up to ten observations that correspond to a single transit into a single so-called normal point. We implemented this input procedure in theGaiaSSO short-term processing pipeline and the OpenOrb software.Results.We validate our approach by performing extensive comparisons between the independent observation and normal point input methods and compare them to the observed positions of previously known asteroids. The new approach reduces the ephemeris uncertainty by a factor of between three and ten compared to the situation where each point is treated as a separate observation.Conclusions.Our new data treatment improves the sky prediction for theGaiaSSO observations by removing low-weight orbital solutions. These solutions originate from excessive curvature of observations, introduced by short-term variations ofGaiaattitude on the one hand, and, as a main effect, shrinking of systematic error bars in the independent observation case on the other hand. We anticipate that a similar approach may also be utilized in a situation where observations from a single observatory dominate.
Universal thermodynamic properties of the intracluster medium over two decades in radius in the X-COP sample
Authors: Ghirardini V. , Eckert D. , Ettori S. , Pointecouteau E. , Molendi S. , Gaspari M. , Rossetti M. , De Grandi S. , Roncarelli M. , Bourdin H. , Mazzotta P. , Rasia E. , Vazza F. 
Published: October 2018

Context.The hot plasma in a galaxy cluster is expected to be heated to high temperatures through shocks and adiabatic compression. The thermodynamical properties of the gas encode information on the processes leading to the thermalization of the gas in the cluster’s potential well and on non-gravitational processes such as gas cooling, AGN feedback, shocks, turbulence, bulk motions, cosmic rays and magnetic field.Aims.In this work we present the radial profiles of the thermodynamic properties of the intracluster medium (ICM) out to the virial radius for a sample of 12 galaxy clusters selected from thePlanckall-sky survey. We determine the universal profiles of gas density, temperature, pressure, and entropy over more than two decades in radius, from 0.01R500to 2R500.Methods.We exploited X-ray information fromXMM-Newtonand Sunyaev-Zel’dovich constraints fromPlanckto recover thermodynamic properties out to 2R500. We provide average functional forms for the radial dependence of the main quantities and quantify the slope and intrinsic scatter of the population as a function of radius.Results.We find that gas density and pressure profiles steepen steadily with radius, in excellent agreement with previous observational results. Entropy profiles beyondR500closely follow the predictions for the gravitational collapse of structures. The scatter in all thermodynamical quantities reaches a minimum in the range [0.2 − 0.8]R500and increases outward. Somewhat surprisingly, we find that pressure is substantially more scattered than temperature and density.Conclusions.Our results indicate that once accreting substructures are properly excised, the properties of the ICM beyond the cooling region (R > 0.3R500) follow remarkably well the predictions of simple gravitational collapse and require few non-gravitational corrections.
Leitlinie „Begutachtung nach gedecktem Schädel-Hirntrauma im Erwachsenenalter“
Authors: Wallesch CW , Marx P , Tegenthoff M , Widder B , Schwerdtfeger K , du Mesnil de Rochemont R , Schmidt R , Neumann-Zielke L , Schwalbe M 
Published: October 2018

Zusammenfassung2005 und 2013 hat die Deutsche Gesellschaft für Neurowissenschaftliche Begutachtung gemeinsam mit anderen Fachgesellschaften und Verbänden „Leitlinien zur Begutachtung nach gedecktem Schädel-Hirntrauma“ erarbeitet und über die Arbeitsgemeinschaft wissenschaftlicher medizinischer Fachgesellschaften (AWMF) sowie in den Fortschritten der Neurologie und Psychiatrie publiziert. Nach 5 Jahren war eine Revision der Leitlinie erforderlich, diese erfolgte erstmals auf der höheren Entwicklungsstufe S 2 k (Expertenkonsens via Delphi-Konferenz).
Evidenzbasierte Behandlung von schwer psychisch kranken Menschen mit psychosozialen Therapien – Erstes Update der DGPPN-S3-Leitlinie erscheint Ende 2018
Authors: Gühne Uta , Weinmann Stefan , Becker Thomas , Riedel-Heller Steffi 
Published: October 2018

Zusammenfassung
Einleitung Schwere psychische Erkrankungen sind mit besonderen Belastungen und Risiken für die Betroffenen und deren Angehörige verbunden. Psychosoziale Therapien sind eine zentrale Säule der Behandlung.
Material & Methoden Im Update der S3-Leitlinie „Psychosoziale Therapien bei schweren psychischen Erkrankungen“ werden auf der Basis aktueller wissenschaftlicher Evidenz und strukturierter Konsensfindung in einem repräsentativen Leitliniengremium umfassende Empfehlungen zur psychosozialen Behandlung gegeben.
Ergebnisse Das Update der Leitlinie umfasst 33 Empfehlungen und 12 Statements in den Bereichen der System- und Einzelinterventionen (z. B. zu Arbeit, Wohnen und Psychoedukation) sowie zu Ansätzen der Selbsthilfe (z. B. zu Selbstmanagement und Peer-Arbeit) sowie zu Aspekten, die die Ausrichtung des täglichen Handelns aller Beteiligten umfassen (z. B. zu Recovery). Ein sogenanntes Matrixkapitel wird den Besonderheiten des deutschen Versorgungssystems gerecht.
Diskussion Es liegt international umfassende wissenschaftliche Evidenz zu verschiedenen psychosozialen Interventionen vor, die Chancen auf eine verbesserte soziale und berufliche Teilhabe für Betroffene eröffnet. Die Implementierung von Leitlinien ist ein wichtiges Entwicklungsfeld, um das Wissen und die Empfehlungen praxiswirksam werden zu lassen.
When Are Trainees Ready to Perform Transvaginal Ultrasound? An Observational Study
Authors: Tolsgaard Martin , Veluppillai Cergika , Gueneuc Alexandra , Taksøe-Vester Caroline , Hajal Nadim , Levaillant Jean-Marc , Ville Yves , Tabor Ann , Chalouhi Gihad 
Published: October 2018

Abstract
Purpose The purpose of this study was two-fold: (1) To determine how the number of ultrasound scans a trainee has completed predicts the trainee’s diagnostic accuracy when performing transvaginal ultrasound examinations, and (2) to examine the utility of simulation-based assessment of ultrasound competence for determining readiness for independently performing examinations.
Materials and Methods 101 OB/GYN trainees were surveyed regarding their clinical experience and the number of scans they had completed. All participants completed five different cases on a transvaginal virtual-reality ultrasound simulator (Scantrainer, Medaphor). The participants’ diagnostic accuracy was recorded and expert raters evaluated their performance using the Objective Structured Assessment of Ultrasound Skills (OSAUS) scale. The utility of simulation-based assessments was assessed with respect to reliability, validity, acceptability, and costs. The main outcome was diagnostic accuracy for five different ultrasound cases.
Results Although the number of scans was associated with diagnostic accuracy (p = 0.006), it was a poor predictor (AUC 0.69) of diagnostic accuracy. Only 56.6 % (n = 34) of participants who had more than 100 transvaginal scans demonstrated a diagnostic accuracy of 0.80 or above. The reliability of the OSAUS assessments was high (ICC 0.82) and the majority of participants supported the use of simulation-based assessments for future licensing exams (70.3 %). The running costs of simulation-based assessments (154 EUR per participant) were lower than for practical examinations using real patients.
Conclusion The number of completed ultrasound scans was a poor predictor of the trainees’ diagnostic accuracy. Instead, simulation-based assessments can be used to ensure that trainees are ready for independently performing future scans.
Identification of a Subtype of Poorly Differentiated Invasive Ductal Carcinoma of the Breast Based on Vimentin and E-cadherin Expression
Authors: Orlandini Leonardo Fleury , Reis Francisco José Cândido dos , da Silveira Willian Abraham , Tiezzi Marcelo Guimarães , de Andrade Jurandyr Moreira , Ribeiro-Silva Alfredo , Deaton Ryan , Bosland Maarten , Tiezzi Daniel Guimarães 
Published: October 2018

Objective The use of molecular markers can identify a subgroup of tumors with distinct recurrence patterns. The present study aimed to characterize the immunohistochemical expression of vimentin (VIM), of E-cadherin (CDH1), and of cytokeratin 5 (CK5) in patients with invasive ductal carcinomas (IDCs).
Methods We have constructed a tissue microarray (TMA) from 87 patients with IDC of the breast. Immunohistochemistry (IHC) was performed to study the expression of estrogen and progesterone receptors (ER and PgR), human epidermal growth factor receptor 2 (HER2), VIM, CDH1, CK5, and Ki67. The tumors were classified as luminal A and B (n = 39), HER2 enriched (n = 25), and triple-negative (TNBC) (n = 23), based on the IHC expression.
Results We have observed that luminal A and B tumors lack the VIM+/CDH1-/low phenotype. This phenotype was observed in 16.5% of the HER2+ tumors and in 60% of the TNBC tumors (p = 0.0001). Out of a total of 20 TNBC tumors, the CK5 (basal-like marker) was positive in 11 of them. The VIM+/CDH1-/low phenotype was observed in 5 CK5+ TNBC tumors (45%) and in 7 out of 9 CK5- TNBC tumors (78%) (p = 0.02). The median Ki67 index in the VIM+/CDH1-/low tumors was 13.6 (range: 17.8–45.4) compared with 9.8 (range: 4.1–38.1) in other tumors (p = 0.0007). The presence of lymph node metastasis was less frequent in patients with VIM+/CDH1-/low tumors (23% versus 61%; X2
test; p = 0.01).
Conclusion Our findings suggest that the expression of VIM and CDH1 can identify a subset of IDCs of the breast with a mesenchymal phenotype associated with poor prognosis, high-grade lesion, and high mitotic index.
Low-carbohydrate high-protein diet diminishes the insulin response to glucose load via suppression of SGLT-1 in mice
Authors: Higashida Kazuhiko , Terada Shin , Li Xi , Inoue Sachika , Iida Noriko , Kitai Saki , Nakai Naoya 
Published: October 2018

ABSTRACT
The purpose of this study was to examine the effects of a low-carbohydrate high-protein (LCHP) diet on the expression of glucose transporters and their relationships to glucose metabolism. Male C57BL/6 mice were fed a normal control or LCHP diet for 2 weeks. An oral glucose tolerance test and insulin tolerance test (ITT) were performed, and the expression of glucose transporters was determined in the gastrocnemius muscle, jejunum and pancreas. The increase in plasma insulin concentrations after glucose administration was reduced in the LCHP group. However, LCHP diet had no effects on peripheral insulin sensitivity or glucose transporters expression in the gastrocnemius and pancreas. Soluble glucose transporter (SGLT)-1 protein content in jejunum was lower in the LCHP group. Taken together, these results suggest that the blunted insulin response after glucose administration in LCHP diet-fed mice might be due to decreased SGLT-1 expression, but not to an increase in peripheral insulin sensitivity.
Abbreviations: LCHP: low-carbohydrate high-protein; ITT: insulin tolerance test; GLUT: glucose transporter; SGLT: soluble glucose transporter; OGTT: oral glucose tolerance test; AUC: area under the curve.
Histone deacetylases in sake yeast affect fermentation characteristics
Authors: Tomimoto Kazuya , Akao Takeshi , Fukuda Hisashi 
Published: October 2018

ABSTRACTYeast histone deacetylases (HDAC) affect the production of alcoholic beverages. In this study, we evaluated the sake fermentation characteristics when using HDAC gene-disrupted yeast strain Kyokai No. 701. Flavor components of the sake product were significantly changed. RPD3 or HDA1 disruption increased twofold the amount of isoamyl acetate, and isoamyl alcohol levels also increased in the rpd3Δ strain. To determine the contribution of Rpd3L and Rpd3S complexes to sake characteristics, a gene responsible for Rpd3L and/or Rpd3S formation was also disrupted. Disruption of DEP1 or SDS3 that is an essential component of Rpd3L led to increased isoamyl alcohol production similar to that of the rpd3Δ strain, but the efficiency of isoamyl alcohol esterification was not affected. In addition, Rpd3 and Hda1 may regulate the responsiveness to oxygen in isoamyl acetate production. We conclude that HDAC genes regulate the production of flavor components during sake fermentation.Abbreviations: HDAC: Histone deacetylase; HAT: histone acetyltransferase; K701: sake yeast Kyokai No. 701; PCR: polymerase chain reaction; HPLC: high performance liquid chromatography; E/A: Ester/Alcohol; BCAA: branched chain-amino acid; Atf: alcohol acetyltransferase.
Flexible design of multiple metagenomics classification pipelines with UGENE
Authors: Rose Rebecca , Golosova Olga , Sukhomlinov Dmitrii , Tiunov Aleksey , Prosperi Mattia 
Published: October 2018

Abstract

Summary
UGENE is a free, open-source, cross-platform bioinformatics software. UGENE deploys pre-defined pipelines and a flexible instrument to design new workflows and visually build multi-step analytics pipelines. The new UGENE v.1.31 release offers graphical, user-friendly wrapping of a number of popular command-line metagenomics classification programs (Kraken, CLARK, DIAMOND), combinable serially and in parallel through the workflow designer, with multiple, customizable reference databases. Ensemble classification voting is available through the WEVOTE algorithm, with augmented output in the form of detailed table reports. Pre-built workflows (which include all steps from data cleaning to summaries) are included with the installation and a tutorial is available on the UGENE website. Further expansion with multiple visualization tools for reports is planned.

Availability and implementation
UGENE is available at http://ugene.net/, implemented in C++ and Qt, and released under GNU General Public License (GPL) version 2.
Incomplete lineage sorting and introgression in the diversification of Chinese spot-billed ducks and mallards
Authors: Wang Wenjuan , Wang Yafang , Lei Fumin , Liu Yang , Wang Haitao , Chen Jiakuan 
Published: October 2018

AbstractIncomplete lineage sorting and introgression are 2 major and nonexclusive causes of species-level non-monophyly. Distinguishing between these 2 processes is notoriously difficult because they can generate similar genetic signatures. Previous studies have suggested that 2 closely related duck species, the Chinese spot-billed duck Anas zonorhyncha and the mallard A. platyrhynchos were polyphyletically intermixed. Here, we utilized a wide geographical sampling, multilocus data and a coalescent-based model to revisit this system. Our study confirms the finding that Chinese spot-billed ducks and Mallards are not monophyletic. There was no apparent interspecific differentiation across loci except those at the mitochondrial DNA (mtDNA) control region and the Z chromosome (CHD1Z). Based on an isolation-with-migration model and the geographical distribution of lineages, we suggest that both introgression and incomplete lineage sorting might contribute to the observed non-monophyly of the 2 closely related duck species. The mtDNA introgression was asymmetric, with high gene flow from Chinese spot-billed ducks to Mallards and negligible gene flow in the opposite direction. Given that the 2 duck species are phenotypically distinctive but weakly genetically differentiated, future work based on genome-scale data is necessary to uncover genomic regions that are involved in divergence, and this work may provide further insights into the evolutionary histories of the 2 species and other waterfowls.
Sociability and pair-bonding in gerbils: a comparative experimental study
Authors: Tchabovsky Andrey V , Savinetskaya Ludmila E , Ovchinnikova Natalia L , Safonova Alexandra , Ilchenko Olga N , Sapozhnikova Svetlana R , Vasilieva Nina A 
Published: October 2018

AbstractIn a study of gerbils with contrasting social and mating systems (group-living monogamous Mongolian gerbil Meriones unguiculatus, solitary nonterritorial promiscuous midday jird M. meridianus, and solitary territorial promiscuous pale gerbil Gerbillus perpallidus), we employed partner preference tests (PPTs) to assess among-species variation in sociability and pair-bonding patterns and tested whether the nature of contact between individuals: direct contact (DC) versus nondirect contact (NDC) affected our results. We measured male preferences as the time: 1) spent alone, 2) with familiar (partner), and 3) unfamiliar (stranger) female in the 3-chambered apparatus. Gerbil species differed strongly in sociability and male partner preferences. The time spent alone was a reliable indicator of species sociability independent of the nature of contact, whereas the pattern and level of between-species differences in male partner preferences depended on contact type: DC PPTs, unlike NDC-tests, discriminated well between monogamous and promiscuous species. In the DC-tests, stranger-directed aggression and stranger avoidance were observed both in the highly social monogamous M. unguiculatus and the solitary territorial promiscuous G. perpallidus, but not in the nonterritorial promiscuous M. meridianus. In M. unguiculatus, stranger avoidance in the DC-tests increased the time spent with the partner, thus providing evidence of a partner preference that was not found in the NDC-tests, whereas in G. perpallidus, stranger avoidance increased the time spent alone. This first comparative experimental study of partner preferences in gerbils provides new insights into the interspecific variation in gerbil sociality and mating systems and sheds light on behavioral mechanisms underlying social fidelity and pair-bonding.
Agricultural Animals as Biomedical Models: Occupational Health and Safety Considerations
Authors: Edwards Gaylen L , Azain Michael J , Parks Andrew 
Published: October 2018

AbstractThe use of agricultural animals in biomedical research is increasing. Their overall size and metabolic rate, organ size, longer gestation period, and other physiological similarities make them good candidates for animal models of human disease. There are a number of special considerations for use of traditional farm animals for biomedical research. Differences in physical plant infrastructure, handling equipment, training of personnel, and potential zoonoses are some of the important considerations when traditional farm animals are used in biomedical research. This article provides an overview of some of the special considerations for using traditional agricultural animals in biomedical research. With the growing need for improved translational research, it is reasonable to predict significant growth in these animal models.
Shaping scientific instrument collections
Authors: Alberti Samuel J M M 
Published: October 2018

Abstract
Many histories of scientific instruments concentrate on their manufacture and original function, but such artefacts as survive often do so in collections – many will have spent far longer in a museum than anywhere else. Alongside the rich literature on the history of scientific instruments, accordingly, there is a body of work on the histories of scientific instrument collections. This survey outlines genres and themes in the historiography of scientific instruments, focusing in particular on display and other collection-based functions. Fluid and contingent, collections are instrumental in the history, heritage, and historiography of science.