bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous Anodic Adsorptive Stripping Voltammetric Determination of Luteolin and 3‐Hydroxyflavone in Biological Fluids Using Renewable Pencil Graphite Electrodes
Authors: Temerk Yassien , Ibrahim Hossieny , Schuhmann Wolfgang 
Published: March 2019

AbstractSimultaneous anodic adsorptive stripping voltammetry was applied for selective and sensitive electrochemical determination of the flavones luteolin (LU) and the basic flavone core 3‐hydroxyflavone (3HF) using a renewable pencil graphite electrode (PGE). The increased separation of the anodic peak potential of LU and 3HF on a PGE surface together with the increased sensitivity renders their simultaneous determination feasible by square wave anodic adsorptive stripping voltammetry (SWAASV). The electrochemical parameters such as surface concentration (Γ), electron transfer coefficient (α), and the standard rate constant (ks) of both LU and 3HF at a PGE were calculated. For simultaneous detection of both compounds by synchronous change of the concentration of LU and 3HF, the detection limits were 1.34 nM and 5.15 nM, respectively. The proposed procedure was successfully applied for the simultaneous detection of LU and 3HF in human serum and urine samples with satisfactory results.
An experimental study of seepage properties of gas‐saturated coal under different loading conditions
Authors: Wang Dengke , Lv Ruihuan , Wei Jianping , Fu Qichao , Wang Yitong , Zhang Ping , Yu Chong , Yao Banghua 
Published: March 2019

AbstractIn order to supply benefits for safe production of coal underground and efficient exploitation of coalbed methane, a self‐developed gas seepage experimental device considering gas adsorption and desorption was proposed to study the seepage properties of gas‐saturated coal in this paper. A series of gas seepage experiments under different loading conditions were carried out to investigate the change rules of permeability of gas‐saturated coal. The experimental results covered the significant effects of confining pressure, gas pressure, temperature change, creep stress, and complete stress‐strain process on the seepage laws of gas‐saturated coal. The experimental results showed that the permeability of gas‐saturated coal is strongly sensitive to the effective stress and decreases with the increase of the effective stress. Under the fixed confining pressure, the permeability of gas‐saturated coal showed an obvious Klinkenberg effect, but the Klinkenberg effect would no longer be evident once the gas pressure was larger than 1.0 MPa. And the change law of permeability of gas‐saturated coal with temperature was mainly reflected in the comprehensive effect of thermal stress and effective stress on the control of pore deformation. Under the complete stress‐strain loading conditions, the change rules of permeability were mainly dependent on the failure mode of gas‐saturated coal. And the change rules of permeability, for the condition of triaxial creep stress, were relied on the stage of creep deformation. The deformation at decay creep stage was responsible for a steady permeability after the failure of gas‐saturated coal, while the deformation at nondecay creep stage was responsible for a rapid increase of permeability after the failure of gas‐saturated coal. The results in this work can offer some helpful suggestions for efficiently exploring coalbed methane in the future.
Zircon U–Pb geochronology, Hf isotopic compositions, and petrogenetic study of Abor volcanic rocks of Eastern Himalayan Syntaxis, Northeast India: Implications for eruption during breakup of Eastern Gondwana
Authors: Singh Athokpam Krishnakanta , Chung Sun‐Lin , Bikramaditya Rajkumar , Lee Hao‐Yang , Khogenkumar Shoraisam 
Published: March 2019

This paper reports new zircon U–Pb ages and Hf isotopic compositions of felsic units of the Abor volcanic rocks (AVR) of Eastern Himalayan Syntaxis (EHS), Northeast India, and discusses their relationship to the Kerguelen plume activity. The AVR are bimodal and predominantly constituted by mafic rocks with minor felsic units. Mafic volcanics are identified as basalt and basaltic andesite with light rare earth elements (LREE) enriched and slightly depleted heavy rare earth elements (HREE) pattern without Eu anomalies. Low concentrations of LILE, high contents of Fe2O3, and other incompatible trace elements ratios reflect enriched nature of these mafic volcanics. Felsic volcanic rocks are dacitic to rhyolitic in composition, which have high REE content, high LREE/HREE, and pronounced negative Eu anomalies. Enriched LREE, high Th/Nb, Ce/Nb ratios, and variations in Rb/Zr, K/Rb, La/Sm ratios with negative anomalies of Ba, Nb, Sr, P, Ti in felsic rocks suggest substantial contribution of crustal contamination at the time of eruption. Zircons from felsic units yield an average U–Pb age of ~132 Ma and unradiogenic (ƐHf(t) < 0) Hf isotope values of −7.0 to −13.3 with model ages between 1.5 and 2.1 Ga, suggesting old crustal assimilation in their genesis. The AVR were emplaced in the continental rift tectonic setting, and depth of the magma source is confirmed as near spinel stability zone. The AVR are positively comparable with other flood basalts that were formed due to the Kerguelen plume activity. Therefore, our combined new geochemical and geochronological data show that the AVR were emplaced at early stage (~132 Ma) of eastern Gondwana breakup due to outbreak of the Kerguelen plume. This study thus supports the idea of the Kerguelen plume affecting a large area of Eastern India, Western Australia, and Antarctica during early stage of Gondwana breakup.
An early warning indicator for liquidity shortages in the interbank market
Authors: Eross Andrea , Urquhart Andrew , Wolfe Simon 
Published: March 2019

AbstractThis study investigates an early warning indicator for liquidity shortages in the short‐term interbank market. To identify structural breaks and their persistence, an autoregressive two‐state regime switching model is presented. The variability in the LIBOR–OIS spread along with thresholds, which delimit four intensities, reveals regime changes consistent with liquidity crashes. The transition between the states is state dependent, and the posterior estimates for the crisis and noncrisis states are estimated using the Gibbs sampler. We forecast our early warning indicator up to December 2011 and show that the estimates are superior to a random walk with drift. Therefore, the model is an effective early warning indicator of an imminent liquidity shortage impacting the interbank market.
Objective analysis and bit rate analysis of HEVC compressed 4D‐fMRI images
Authors: Raut Yudhishthir , Gamad R. S. , Bansod P. P. 
Published: March 2019

AbstractMedical imaging and clinical diagnostics are complementary to one another since their analysis is typical and contains critical information. The growing volume of data has become one of the biggest challenges, as the acquisition of medical modalities is currently having high resolution from the improved and efficient machines (3 to 7 T or more). Moreover, image and video compression is a need with the consideration that there should not be any gap for losing the important information. Less bitrate requirement with high compression ratio without sacrificing important detail is a challenge these days. The current study, is dealing with the compression of 4D‐functional medical resonance images (fMRI) with a codec, that is, high‐efficient video coding (HEVC/H.265) and its objective analysis along with its predecessor that is advanced video coding (AVC/H.264) and with VP8 (WebM Project of Google) reported here. Further, the bit rate analysis that has been conducted, also accounts in conjunction with the bitrate investigation, which is an imperative perspective vital for the telemedicine field. The simulation results reported here represents the compression ratio (CR = 118.23:1) with HEVC/H.265 codec over the compression ratio (CR = 20.52:1) provided by AVC/H.264 and VP8 (CR = 78.29:1). There has been significant improvement observed in alignment of the peak signal‐to‐noise ratio (APSNR), structural similarity (SSIM), and mean squared error (MSE) metrics. Overall, the performance of the anticipated technique is satisfactory for the forthcoming telemedicine or clinical use.
Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial
Authors: Duckworth Andrew D , McQueen Margaret M , Tuck Christopher E , Tobias Jonathan H , Wilkinson Jeremy Mark , Biant Leela C , Pulford Elizabeth Claire , Aldridge Stephen , Edwards Claire , Roberts Chris P , Ramachandran Manoj , McAndrew Andrew Richard , Cheng Kenneth CK , Johnston Phillip , Shah Nasir H , Mathew Philip , Harvie John , Hanusch Birgit C , Harkess Ronnie , Rodriguez Aryelly , Murray Gordon D , Ralston Stuart H 
Published: March 2019

ABSTRACT

There is a concern that bisphosphonates may impair fracture healing because of their inhibitory effects on bone turnover. Here we evaluated the effects of early bisphosphonate therapy on fracture healing and functional outcome following a fracture of the distal radius. The fracture and bisphosphonates (FAB) trial was a double-blind, randomized, placebo-controlled trial involving 15 trauma centers in the United Kingdom. We enrolled 421 bisphosphonate-naive patients aged ≥50 years with a radiographically confirmed fracture of the distal radius and randomized them in a 1:1 ratio to receive alendronic acid 70 mg once weekly (n = 215) or placebo (n = 206) within 14 days of the fracture. The primary outcome measure was the proportion of fractures that had radiologically united at 4 weeks as assessed by an observer, blinded to treatment allocation. Secondary outcomes included the Disabilities of the Arm Shoulder and Hand (DASH) questionnaire, range of wrist movement and grip strength, pain and analgesia requirements, and the rate of malunion. The mean ± SD age of participants was 63 ± 8.5 years and 362 (86%) were female. At 4 weeks, 48 of 202 (23.8%) fractures had united in the alendronic acid group compared with 52 of 187 (27.8%) in the placebo group (observed absolute proportion difference 4.0%; 95% CI, –4.7% to 12.8%; p = 0.36). The absolute proportion difference between groups based on imputed data was 4.5% (95% CI, –4.7% to 13.8%; p = 0.30). There was no significant difference in the proportion of fractures that had united at any other time point and no differences in the DASH score, pain at the fracture site, grip strength, or any other clinical outcome. We conclude that among patients aged 50 years and above with a distal radius fracture, early administration of alendronic acid does not adversely affect fracture union or clinical outcome. These findings suggest bisphosphonate therapy can be safely commenced early after fracture if clinically indicated. © 2019 American Society for Bone and Mineral Research.
Prevalence of Hepatitis C virus genotypes in nine selected European countries: A systematic review
Authors: Petruzziello Arnolfo , Loquercio Giovanna , Sabatino Rocco , Balaban Daniel Vasile , Ullah Khan Najeeb , Piccirillo Mauro , Rodrigo Luis , di Capua Lucia , Guzzo Annunziata , Labonia Francesco , Botti Gerardo 
Published: March 2019

BackgroundHepatitis C virus (HCV) infection is a global health problem especially for its increasing level of mortality. Detailed knowledge of HCV genotypes prevalence has clinical relevance since the efficacy of therapies is impacted by genotypes and subtypes distribution. Moreover, HCV exhibits a great genetic variability regionally.To date, there are no published studies assessing HCV genotypes distribution in specific countries of the Mediterranean basin. The aim of this study was to review data published from 2000 to 2017 with the purpose to estimate genotypes distribution of HCV infection in nine European countries all located in the Mediterranean basin.MethodsA systematic research of peer‐reviewed journals indexed in PubMed, Scopus, and EMBASE databases selected if containing data regarding distribution of HCV genotypes in nine selected European countries (Albania, Bosnia, Croatia, France, Greece, Italy, Montenegro, Slovenia, and Spain) was performed.ResultsGenotype 1 is the most common (61.0%), ranging from 80.0% in Croatia to 46.0% in Greece, followed by genotype 3 (20.0%), varying from 38.0% in Slovenia to 7.0% and 8.0%, respectively, in Italy and in Albania and by genotype 4 (10.0%) that shows an increase of 1.1% with respect to data obtained till 2014 probably due to the increasing migrants arrivals to Southern Europe. G2, the fourth most frequent genotype (8.5%), particularly common in Italy (27.0%) and Albania (18.0%) might be probably introduced in Southern Italy as a result of Albanian campaign during Second World War and more and more increased by the migration flows from Albania to Italy in the 90s.ConclusionEpidemiology of HCV infection shows a high variability across the European countries that border the Mediterranean Sea. HCV genotyping is a relevant tool to monitor the dynamic process influenced by both evolving transmission trends and new migration flows on HCV scenario.
Establishing and validating of an laboratory information system‐based auto‐verification system for biochemical test results in cancer patients
Authors: Yan Cuie , Zhang Yujuan , Li Jia , Gao Jia , Cui Chanjuan , Zhang Chun , Song Guiyu , Yu Mengyao , Mu Jianjun , Chen Feng , Han Xiaohong , Cui Wei 
Published: March 2019

BackgroundTo establish and validate an laboratory information system (LIS)‐based auto‐verification (AV) system by using large amounts of biochemical test results in cancer patients.MethodsAn algorithm of the AV process was designed for pre‐analysis, analysis, and post‐analysis. The limit range check was adjusted three times, while the delta check criteria were first replaced by the same patients’ historical extremum results. AV rules of 51 biochemical test items were tested by using data of 121 123 samples (6 177 273 tests) in 2016 that were manually reviewed through the simulative i‐Vertification software of Roche. The improved and optimal AV rules were programed into our LIS and validated by using 140 113 clinical specimens in 2018.ResultsThe AV passing rate for samples tested in our laboratory increased from 15.57% to the current overall passing rate of 49.70%. The passing rate of each item for rule 3 was between 71.16% and 99.91%. Different cancer groups had different passing rate, while the disease group of liver, gallbladder, and pancreas always had the lowest passing rate. A total of 9420 reports (6.72%) were not verified by AV but could be verified by MV in 2018, while there were no reports that were verified by AV but not by MV. The TAT of March 2018 decreased with increase in sample size compared with the same time in 2017.ConclusionWe have firstly established an LIS‐based AV system and implemented it in actual clinical care for cancer patients.
Pooled analysis of nuclear acid sequence‐based amplification for rapid diagnosis of Mycoplasma pneumoniae infection
Authors: Huang Chong , Huang Pei‐Ting , Yao Jie‐Ying , Li Zhong‐Wei , Weng Luo‐Bei , Guo Xu-Guang 
Published: March 2019

BackgroundMycoplasma pneumoniae (M pneumoniae) is a common human etiology of respiratory infections. Nuclear acid sequence‐based amplification (NASBA) shows good value for the detection of M pneumoniae that surpasses PCR. However, the optimal detection technology still remains to be identified. The purpose of this meta‐analysis was to systematically evaluate the overall accuracy of NASBA for diagnosing M pneumoniae infections.MethodsThe databases PubMed, Cochrane Library, Google Scholar, CNKI, Wang Fang, and Baidu Scholar were comprehensively searched from their initiation date to December 2017 for NASBA in the diagnosis of M pneumoniae infection. Meta‐DiSc 1.4 statistical software was used to evaluate the sensitivity (SEN), specificity (SPE), negative likelihood ratio (−LR), positive likelihood ratio (+LR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC). RevMan 5.2 statistical software was used for quality evaluation of the included articles. Publication bias was evaluated by funnel plot.ResultsSix articles with high quality, including 10 studies, were finally included in this meta‐analysis. The combined statistics results for the diagnosis of M pneumoniae infection by NASBA were 0.77 (SEN, 95% CI: 0.71 to 0.82); 0.98 (SPE, 95% CI: 0.98 to 0.99); 0.22 (‐LR, 95% CI: 0.13 to 0.39); 50.38 (+ LR, 95% CI: 21.85 to 116.17); 292.72 (DOR, 95% CI: 95.02 to 901.75); and 0.9875 (the area under the curve of SROC).ConclusionNuclear acid sequence‐based amplification is a reliable technique to diagnose M pneumoniae infection. However, whether it can replace PCR and serology need to be further studied.
Radiosynthesis of the norepinephrine transporter tracer [18F]NS12137 via copper‐mediated 18F‐labelling
Authors: Lahdenpohja Salla , Keller Thomas , Rajander Johan , Kirjavainen Anna K. 
Published: March 2019

[18F]NS12137 (exo‐3‐[(6‐[18F]fluoro‐2‐pyridyl)oxy]8‐azabicyclo[3.2.1]octane) is a highly selective norepinephrine transporter (NET) tracer. NETs are responsible for the reuptake of norepinephrine and dopamine and are linked to several neurodegenerative and neuropsychiatric disorders. The aim of this study was to develop a copper‐mediated 18F‐fluorination method for the production of [18F]NS12137 with straightforward synthesis conditions and high radiochemical yield and molar activity. [18F]NS12137 was produced in two steps. Radiofluorination of [18F]NS12137 was performed via a copper‐mediated pathway starting with a stannane precursor and using [18F]F− as the source of the fluorine‐18 isotope. Deprotection was performed via acid hydrolysis. The radiofluorination reaction was nearly quantitative as was the deprotection based on HPLC analysis. The radiochemical yield of the synthesis was 15.1 ± 0.5%. Molar activity of [18F]NS12137 was up to 300 GBq/μmol. The synthesis procedure is straightforward and can easily be automated and adapted for clinical production.
Using a new regularized factorization method for unconstrained optimization problems
Authors: Dehghan Niri Tayebeh , Shahzadeh Fazeli Seyed Abolfazl , Hosseini Mohammad Mehdi 
Published: March 2019

AbstractIn this paper, a new regularized factorization method is presented for solving unconstrained minimization problems in which the Hessian matrix may not be a positive definite or may be close to singular. With employing the modified quadrant interlocking factorization (QIF), an efficient algorithm is developed to find a suitable method. Moreover, under suitable conditions, the global convergence of the proposed method is established. Some interesting examples are solved by the proposed method and the improved Cholesky factorization method. The results show that the proposed method, in the most cases, the algorithm has a faster convergence than the improved Cholesky factorization method.
The Preparation of a Novel Corrosion Inhibitor and Its Corrosion Inhibition Behavior on 2024 Al‐Cu‐Mg Alloy in Acid Solution
Authors: Juan Du , Shuai Jia , Fan Yang , Ziming Wei , Haipeng Song , Xudong Yang , Fusheng Wang 
Published: March 2019

AbstractA new corrosion inhibitor was synthesized from chloroacetyl chloride, 1,3‐propanediamine, and dodecyldimethyl tertiary amine. The structure of the synthesized product was characterized using Fourier transform infrared(FTIR). The critical micelle concentration (CMC) was determined from surface tension measurements. The inhibition behavior of the corrosion inhibitor for 2024 Al‐Cu‐Mg alloy was studied using the weight‐loss method and electrochemical measurements in hydrochloric acid solution. Experimental results show: The CMC is 7.767 × 10−4 mol L−1 and IE (C
pro = 1 × 10−3 mol L−1) ≈ 87.9%. The adsorption free energy is calculated to be −33.12 kJ mol−1. Therefore, the adsorption mode is more inclined to physical adsorption. When the concentration of the synthesized product is lower than the CMC, it satisfies the Langmuir adsorption model; when the concentration is higher than the CMC, it no longer follows the Langmuir adsorption model.
A national analysis of patterns of care and outcomes for adults diagnosed with desmoplastic small round cell tumors in the United States
Authors: Gani Faiz , Goel Utkarsh , Canner Joseph K. , Meyer Christian F. , Johnston Fabian M. 
Published: March 2019

AbstractBackgroundBecause of the rarity of desmoplastic small round cell tumors (DSRCT), there is a lack of data describing patterns of care and survival for these patients. Using a national tumor registry, the current study sought to describe patterns of care and clinical outcomes for patients with DSCRT.MethodsData from the National Cancer Database were used to identify 491 patients aged 18 years or older diagnosed with DSRCT between 2004 and 2014. Multivariable Cox proportional hazards regression analysis was used to identify factors associated with overall survival (OS).ResultsAmong all patients, 41.2% (n = 200), underwent surgical resection of their primary tumor, chemotherapy was administered to 86.5% (n = 415) of patients, while radiation therapy was administered to 13.0% (n = 63) of patients. Over the study, 69.7% of patients died with a median OS of 25.9 months (interquartile range [IQR]: 22.7‐27.5); 1‐, 3‐, and 5‐year OS were 78.6%, 32.3%, and 18.4%, respectively. On multivariable analysis, stage IV disease (Hazard ﻿Ratio [HR] = 2.12, 95% CI: 1.41‐3.18), receipt of surgery (HR = 0.68, 95% CI: 0.50‐0.91), chemotherapy (HR = 0.52, 95% CI: 0.35‐0.78), or radiation therapy (HR = 0.55, 95% CI: 0.33‐0.92) were independently associated with OS.ConclusionsAlthough receipt of multimodality treatment may lead to improved survival, further research and clinical trials are required to establish best practices for the care of DSRCT.
Screening and isolation of cyclooxygenase‐2 inhibitors from the stem bark of Phellodendron amurense Ruprecht by ultrafiltration with liquid chromatography and tandem mass spectrometry, and complex chromatography
Authors: Li Sainan , Zhang Yuchi , Shi Dongfang , Hou Wanchao , Xia Jianli , Liu Chunming 
Published: March 2019

AbstractNonsteroidal anti‐inflammatory drugs appear to reduce the risk of developing cancer. One mechanism through which nonsteroidal anti‐inflammatory drugs act to prevent carcinogenesis is inhibition of the activity of the enzyme cyclooxygenase‐2. The cyclooxygenase‐2 inhibitors are widely used to reduce the risk of developing cancer. Natural products are considered to be a promising source of several novel cyclooxygenase‐2 inhibitors. Ultrafiltration with liquid chromatography and mass spectrometry is an efficient method that can be applied to rapidly screen and identify the ligands from the barks of Phellodendron amurense Ruprecht. A continuous online method comprised of pressurized liquid extraction, countercurrent chromatography, and semi‐preparative liquid chromatography was developed for the efficient scaled‐up production of eight compounds with high purities. The bioactivities of the separated compounds were assessed by an in vitro enzyme inhibition assay. The use of bioactivity screening method combined with preparation method of bioactive compounds and an in vitro enzyme inhibition assay facilitated the efficient screening and isolation of the cyclooxygenase‐2 inhibitors from complex samples. This could be used as an efficient method for the large‐scale production of functional ingredients.