bluuebunny/crossref_metadata_2025_split huggingface dataset:
El desarrollo del modelo flipped classroom en la universidad: impacto de su implementación desde la voz del estudiantado
Authors: Del Arco Bravo Isabel , Flores Alarcia Óscar , Silva García Patricia 
Published: July 2019

El progreso del mundo digital ha generado un cambio radical en la manera de acceder y transmitir el conocimiento. El aprendizaje ha dejado de ser una actividad interna e individual para pasar a ser una actividad colectiva y en red. Este artículo describe los resultados de un estudio cuantitativo que tuvo como objetivo analizar las percepciones y valoraciones de estudiantes de la Universidad de Lleida en relación con la implementación del modelo flipped classroom. Se aplicó un cuestionario diseñado ad hoc. Los datos se recogieron de manera longitudinal durante dos cursos académicos, 2015-2016 y 2016-2017. La muestra del estudio fue de 259 participantes. Los resultados muestran que mejoró la experiencia de aprendizaje y su efectividad, siendo los resultados más positivos en los estudiantes de mayor edad. De entre las conclusiones destacamos que este modelo genera una mayor motivación entre los estudiantes, pero al mismo tiempo mayores niveles de corresponsabilidad y compromiso en estudiantado y profesorado.
The progress in the digital world has generated a radical change in the way to access and transmit knowledge. The learning process is no more an internal and individual activity; nowadays is a collective activity in the network. This article describes the results of a quantitative study which purpose was to analyse the students’ perceptions and valuations regarding the implementations of the flipped classroom model. An ad hoc questionnaire was designed. Data were collected longitudinally during two academic years, 2015-2016 and 2016-2017. The sample of the study was 259 participants. Results show that in general learning experience and its effectivity improve, being the most positive results in the older students. Among the conclusions we highlight that the model improves students’ motivation but it requires high levels of responsibility and commitment in both students and teachers.
El aprendizaje cooperativo en la formación de maestros de Educación Primaria
Authors: Izquierdo Rus Tomás , Martínez Elena Asensio , Frutos Andrés Escarbajal , Moreno Javier Rodríguez 
Published: July 2019

La universidad es un contexto de aprendizaje, en el que el alumnado es el responsable de tomar sus propias decisiones, controlar su propio proceso de aprendizaje y las interacciones que intervienen en él. En los grados como el de Educación Primaria, el progreso del aprendizaje no depende sólo de un individuo, sino del esfuerzo conjunto de un grupo de iguales, cuyo desempeño se ve reflejado en el aprendizaje individual. Así, los objetivos del presente trabajo han sido establecer cómo se desarrolla el concepto de trabajo en grupo y las estrategias que ponen en marcha para llevarlo a cabo en función de su satisfacción. Los participantes de esta investigación han sido 523 estudiantes del Grado de Educación Primaria de las Universidades de Murcia y de Jaén. Para ello se ha utilizado un cuestionario tipo Likert con cuyos resultados se ha establecido una comparación entre el alumnado que inicia el grado en Educación Primaria y aquellos que ya tienen varios años de experiencia en el ambiente universitario. Destacar como principales resultados y conclusiones que el alumnado desarrolla un concepto del trabajo en grupo que se mantiene estable en el tiempo. Sin embargo, la utilidad que creen que les reporta el trabajo en grupo sí puede cambiar, influenciados por las exigencias del contexto. Así mismo, cuando el alumnado está satisfecho con el trabajo de su grupo confían más en sus propias habilidades y capacidades para construir su conocimiento.
The university is a learning context, where the students are responsible for making their own decisions and controlling their own learning process and the interactions that intervene in it. Not only that, in degrees such as Primary Education, the progress of learning does not depend only on an individual, but on the joint effort of a peer group, whose performance is reflected in the individual learning. Thus, the objectives of this paper have been to establish how the concept of group work is developed and the strategies that are put in place to carry it out according to their satisfaction. The participants of this research have been 523 students of the Degree of Primary Education of the University of Murcia and the University of Jaen. To this end, a Likert questionnaire has been used, with the results of which a comparison has been established between the students who start the degree in Primary Education and those who already have several years of experience in the university environment. The main results and conclusions confirm that the students develop a concept of group work that remains stable over time. However, the usefulness that they believe that group work brings can change, influenced by the demands of the context. Additionally, when students are satisfied with the work of their group, they rely more on their own skills and abilities to build their knowledge.
La formación en TIC de los pedagogos de música. Análisis de la situación en las Enseñanzas Superiores de Música
Authors: Díez Latorre Nuria 
Published: July 2019

La incorporación de las tecnologías de la información y la comunicación (TIC) a la enseñanza en los conservatorios de música es, a día de hoy, muy escasa y desigual. Independientemente de otros factores, uno de los motivos puede ser la falta de formación del profesorado en esta materia; sin embargo, sobre este tema existe todavía muy poca información. Por ello, este informe ofrece una panorámica sobre la formación en TIC que reciben actualmente los futuros pedagogos de música durante sus estudios en el conservatorio superior. Para ello se ha llevado a cabo un extenso análisis de contenido de los planes de estudio de Pedagogía Musical y guías docentes de catorce centros repartidos por todo el territorio español. Los resultados revelan que, en general, los contenidos tecnológicos se centran en el manejo de software musical pero la formación en TIC para la educación es bastante deficitaria y existen grandes diferencias entre los distintos centros.
Interações on-line nas atividades de orientação de trabalhos finais de curso: um estudo sobre as práticas dos orientadores no Brasil e Portugal
Authors: Constantino Paulo Roberto Prado , Henriques Susana 
Published: July 2019

Este artigo é parte de uma investigação mais ampla sobre os fundamentos e práticas de orientação dos trabalhos finais de cursos em modalidades on-line [dissertações, teses, monografias, projetos experimentais], com foco sobre instituições educacionais superiores em Portugal e no Brasil. No presente, a reflexão assenta-se sobre as interações on-line desenvolvidas durante estas orientações. A partir da análise de conteúdo em entrevistas com oito professores, pretendeu-se um mapeamento das preferências e práticas de interações, analisando aspectos que envolvem os canais comunicacionais e seus recursos e tipos; os tempos e modos para interações síncronas e assíncronas e a sua periodicidade; a formação de redes sociais e comunidades de aprendizagem; e os substratos das relações entre os indivíduos e da criação de redes comunicacionais com finalidades de aprendizagem. Os resultados apontam algumas diretivas para a educação on-line, como contributos da pesquisa.
Inclusão digital e práticas de leitura em um telecentro de uma comunidade quilombola
Authors: Velloso Maria Jacy Maia , Castanheira Maria Lúcia 
Published: July 2019

No contexto de implementação de políticas públicas de inclusão digital no território brasileiro,o artigo analisa as práticas de leitura associadas ao uso do computador e da internetem um telecentro de uma comunidade quilombola, Paineiras, situada ao norte de MinasGerais, Brasil. Foram adotadas a abordagem do Letramento como Prática Social e umaperspectiva etnográfica para a análise de como e porquê os usuários do telecentro utilizamo computador e a internet e que ações e interações desenvolvem com o estabelecimentodesse telecentro na comunidade. A análise dos eventos de leitura observados no telecentrotornou visível duas modalidades de uso dos computadores, que foram classificadascomo modalidade de uso livre e modalidade de uso orientado. O contraste entre essasmodalidades evidenciou que as práticas de leitura na primeira modalidade estavam mais diretamente vinculadas a interesses pessoais e funções sociais da escrita no contexto digital, particularmente a comunicação com amigos e parentes em redes sociais. Em contraposição, as práticas de leitura desenvolvidas de maneira orientada durante o curso de informática oferecido aos moradores de Paineiras, apresentaram natureza descontextualizada e sem vínculos com as experiências e necessidades vivenciadas pelos alunos em outros espaços sociais, privilegiando o ensino das funções dos softwares (e.g. Excel, Word). Evidenciou-se que as reivindicações, as necessidades, os conhecimentos e os interesses da população não têm sido consideradas no processo de desenvolvimento de cursos de inclusão digital, o que desmotiva os alunos a participarem das atividades propostas e limita as possibilidades de aprendizagem por parte deles.
Nomogram to predict the prognosis of parotid gland mucoepidermoid carcinoma: a population-based study of 1306 cases
Authors: Sun Jian , Sun Yang , Yang Fei , Zhou Qianrong , Liu Wenjuan , Cheng Yong , Wu Xingwen , Chen Tinglan , Li Ruixue , Huang Borui , Att Wael , Yu Youcheng , Bi Wei 
Published: July 2019

Background
Mucoepidermoid carcinoma (MEC) is a common cancer in the oral salivary gland malignancy, which mainly occurs in the parotid gland. The aim of this study is to identify independent prognostic factors and establish a nomogram model for parotid gland mucoepidermoid carcinoma (P-MEC) patients using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database.

Method
Patients with P-MEC were selected from between 2004 and 2015. The overall survival (OS) and cancer-specific survival (CSS) rates were estimated using the Kaplan-Meier method with the log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were performed to identify the independent prognostic factors.

Results
A total of 1,306 patients with P-MEC were enrolled. Age, grade, T stage, N stage, M stage, chemotherapy, and surgery type were independent prognostic factors for OS and CSS. A nomogram for OS was formulated based on these independent prognostic factors and validated using an internal bootstrap resampling approach, which showed that the nomogram exhibited a sufficient level of discrimination according to the C-index (0.877, 95% CI [0.855–0.898]).

Conclusion
Several prognostic factors for P-MEC were identified. The nomogram developed in this study accurately predicted the 5- and 10-year OS rates of American patients with P-MEC based on individual characteristics. Risk stratification using the survival nomogram can optimize individual therapies and follow-up.
The Mechanical and In vitro Release Properties of Diazepam from Tablets Containing Fluid Bed Dried and Lyophilized Cocos nucifera Microcrystalline Cellulose
Authors: Nwachukwu Nkemakolam , Ofoefule Sabinus Ifeanyi 
Published: July 2019

Aim: This study aimed to evaluate the mechanical and in vitro release properties of diazepam from tablets containing fluid bed dried and lyophilized microcrystalline cellulose (MCC) obtained from the matured fruit husks of Cocos nucifera (CN).
Study Design: Method of experiment.
Place and Duration of Study: Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka from March 2015 to September, 2016
Methods: Dried CN fruit husks were digested in sodium hydroxide to obtain alpha (α) cellulose which on hydrolysis with mineral acid (Hydrochloric acid) solution gave CN-MCC. The dry MCC obtained by either fluid bed or lyophilized drying of the wet CN-MCC were coded MCCF-Cocos and MCCL-Cocos respectively. Both MCCs were used in the formulation of diazepam tablets at 20, 30 and 40% w/w. Avicel PH 102 (AVC-102), was used as comparing standard. The tablets were evaluated for physical and dissolution properties using standard methods.
Results: Results show the tablets passed the British Pharmacopoeia specifications for weight uniformity, crushing strength, disintegration time, friability and dissolution. Diazepam tablets containing MCCL-Cocos (coded DCL) were mechanically stronger than those containing MCCF-Cocos (coded DCF). Disintegration time was in the order of DCF > DCL tablets while friability was in the order of DCL < DCF tablets. Diazepam tablets containing AVC-102 (coded DAV) were mechanically stronger than DCL and DCF tablets. The dilution potential was in the order DAV > DCL > DCF. More than 80% of the diazepam content was released from DAV, DCL and DCF tablets.
Conclusion: Generally, DAV, DCL and DCF tablets met the British Pharmacopoeia limits for mechanical properties and in vitro drug release with DCL tablets showing significantly (P = .05) superior mechanical properties while DCF showed faster drug release.
Effect of long-acting aripiprazole monohydrate on inpatient encounters: A retrospective mirror image study
Authors: Aguilar Monica , Malcolm Benjamin 
Published: July 2019

Abstract

Introduction
Antipsychotics improve symptoms associated with schizophrenia and bipolar disorder. To improve medication adherence and decrease the need for hospitalization, many antipsychotics have been developed into long-acting injectable (LAI) formulations. Though mirror-image studies have demonstrated significantly decreased hospitalization rates with LAI use, there is limited data when suboptimal use parameters are present.

Methods
A retrospective chart review was conducted on patients who were administered aripiprazole monohydrate long-acting injectable (AM-LAI) in an adult mental health unit. Demographics and AM-LAI use parameters were analyzed descriptively. Endpoints compared the days between encounters pre and post AM-LAI administration and number of inpatient encounters between the 180 days pre and post AM-LAI administration. Effects of AM-LAI on inpatient encounters were analyzed using a Wilcoxon signed rank test with an alpha set to &lt;0.05 for significance.

Results
Fifty-eight patients met inclusion criteria. Mean (± SD) age was 39.4 (11.4) years with 55.2% of the sample male. Most patients were diagnosed with schizophrenia or unspecified psychotic disorder and admitted involuntarily. The mean number of days from last admission to the date of initial AM-LAI administration was 109.3 (75.2), compared with 131.3 (69.8) days to next encounter (P = .044) post AM-LAI. Total inpatient encounters were also reduced (P = .004), although no differences in encounters for psychiatric reasons were detected.

Discussion
Use of AM-LAI was associated with a prolonged time to next inpatient encounter and reduced total inpatient encounters, however its use failed to demonstrate reductions in psychiatric encounters.
Public perceptions of naloxone use in the outpatient setting
Authors: Smith Jordan O. , Malinowski Scott S. , Ballou Jordan M. 
Published: July 2019

Abstract

Introduction
Naloxone has become an important component of preventing deaths from opioid overdose. Although studies have confirmed its cost-effectiveness, naloxone is rarely prescribed proactively in case of accidental overdose. The perception still exists that a reversal agent may enable patients with opioid use disorder to continue abusing opioids without fear of death from overdose. This study was designed to determine the general public's knowledge of naloxone and their perceptions about receiving a naloxone prescription with opioid use.

Methods
Participants were recruited through Amazon Mechanical Turk (MTurk), where a link directed participants to an electronic survey. Participants were included if they were 18 years of age or greater and currently living in the United States. Participants were paid $0.10 USD via Amazon MTurk upon completing the survey.

Results
Four hundred five participants successfully completed the survey, and 61% were aware that there is a medication available to treat opioid overdose. The majority of participants responded positively to the idea of acquiring naloxone. Responses were evenly split for agreeing and disagreeing with the statement “naloxone is only necessary for people who abuse opioids.” Although 51% of respondents believed that having naloxone available enables people who abuse opioids, 88% agreed that naloxone is beneficial for people who accidentally overdose on opioids. A majority believed that naloxone should be made available upon request to anyone concerned about opioid overdose.

Discussion
Participants were generally aware of the availability of an opioid reversal agent and responded positively to 3 different methods of acquiring naloxone through their prescriber or pharmacist.
Description of a pharmacist-led clinical video telehealth group clinic for opioid overdose prevention and naloxone education
Authors: Jensen Aimee N. , Beam Candace M. , Douglass Amber R. , Brabson Jennifer E. , Colvard Michelle , Bean Jennifer 
Published: July 2019

Abstract
To achieve the nationwide goal of reducing opioid-related deaths, a clinical pharmacy specialist–led clinical video telehealth (CVT) clinic was created at a Veterans Affairs medical center (VAMC) to deliver opioid overdose prevention and naloxone education to at-risk patients. The purpose of this innovative practice was to improve access to this potentially life-saving intervention to patients across urban and rural areas. This study is a single-center, descriptive analysis of adult patients across 2 VAMC campuses and 4 community-based outpatient clinics from July 11, 2016, through December 31, 2016. The purpose of this innovative practice was to increase access to overdose education and naloxone distribution (OEND) to at-risk patients across urban and rural areas. Patient-specific factors were also examined among those receiving naloxone through the CVT clinic compared to other prescribers. During the first 6 months from the initiation of the clinic, 1 pharmacist prescribed 21% of the health care system's naloxone. These patients identified by the pharmacist-led CVT clinic were more likely to be considered high-risk due to concomitant use of opioids and benzodiazepines. In conclusion, the pharmacist-led CVT group clinic has been an efficient strategy to extend OEND services to high-risk patients beyond central, urban areas.
Abandonment of previous treatment and case of resistant multidrug tuberculosis in a tertiary institution in the city of Rio de Janeiro / Abandono de tratamento anterior e caso de tuberculose multidroga resistente em uma instituição terciária na cidade do Rio de Janeiro
Authors: Ferreira Débora Paula , Souza Fabiana Barbosa Assumpção de , Motta Maria Catarina Salvador da 
Published: July 2019

Objetivos: Descrever as características dos casos de abandono do tratamento de tuberculose em pacientes que desenvolveram TBMR. Métodos: Estudo descritivo de abordagem quantitativa, desenvolvido em uma instituição terciária de referência para tratamento de TBMR localizada na cidade do Rio de Janeiro. Foi utilizado instrumento estruturado com informações de quarenta prontuários entre os meses de agosto a dezembro de 2016. A análise dos dados foi realizada através do software SPSS. Resultados: dos pacientes estudados, 35% abandonaram tratamento anterior de Tuberculose.Conclusão e implicação para a prática: é necessária a identificação precoce de pacientes que apresentam maior risco para abandono do tratamento, bem como a criação de um modelo de assistência voltado ao perfil dos usuários que abandonam o tratamento, com uma prática participativa, com grupos educativos que promovam ações preventivas, identificando, estudando estratégias para a superação de barreiras ligadas à realidade, de vida individual e coletiva.
Progesterone receptor activation regulates seizure susceptibility
Authors: Shiono Shinnosuke , Williamson John , Kapur Jaideep , Joshi Suchitra 
Published: July 2019

AbstractObjectiveProgesterone is a potent neuromodulator that exerts effects on the brain through neurosteroids, progesterone receptors (PRs), and other molecules. Whether PR activation regulates seizures is not known. We determined whether PR activation increased seizure susceptibility.MethodsAdult female rats that developed epilepsy following lithium‐pilocarpine‐induced status epilepticus (SE) were used. Seizures were recorded by continuous‐video EEG and read by an individual blinded to the treatment of the animals. The animals were treated for a week with progesterone (50 mg/kg per day), and the effect of progesterone withdrawal on seizure frequency was assessed during the subsequent week. During the week of progesterone treatment, the animals were treated with PR antagonist RU‐486 (10 mg/kg per day) or a vehicle control, which was administered 30 min before progesterone. In another set of animals, we determined the effect of the PR agonist Nestorone (3 mg/kg per day) on seizure frequency. The animals were treated with Nestorone or vehicle for a week, and seizure frequencies at baseline and during the treatment week were compared.ResultsProgesterone withdrawal induced twofold increase in seizures in 57% of animals (n = 14). RU‐486 treatment in combination with progesterone, prevented this increase, and a smaller fraction of animals (17%) experienced withdrawal seizures (n = 13). The specific activation of PRs by Nestorone also increased the seizure frequency. Forty‐six percent (n = 14) of Nestorone‐treated animals experienced at least a 50% increase in seizures compared to only 9% of the vehicle‐treated animals (n = 11).InterpretationPR activation increased seizure frequency in epileptic animals. Thus, PRs may be novel targets for treating catamenial epilepsy.
Acoustic enhancement of sleep slow oscillations in mild cognitive impairment
Authors: Papalambros Nelly A. , Weintraub Sandra , Chen Tammy , Grimaldi Daniela , Santostasi Giovanni , Paller Ken A. , Zee Phyllis C. , Malkani Roneil G. 
Published: July 2019

AbstractObjectiveSlow‐wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep‐dependent memory consolidation. Acoustic stimulation of slow oscillations has proven effective in enhancing SWA and memory in younger and older adults. In this study we aimed to determine whether acoustic stimulation during sleep boosts SWA and improves memory performance in people with aMCI.MethodsNine adults with aMCI (72 ± 8.7 years) completed one night of acoustic stimulation (stim) and one night of sham stimulation (sham) in a blinded, randomized crossover study. Acoustic stimuli were delivered phase‐locked to the upstate of the endogenous sleep slow‐waves. Participants completed a declarative recall task with 44 word‐pairs before and after sleep.ResultsDuring intervals of acoustic stimulation, SWA increased by >10% over sham intervals (P < 0.01), but memory recall increased in only five of the nine patients. The increase in SWA with stimulation was associated with improved morning word recall (r = 0.78, P = 0.012).InterpretationAcoustic stimulation delivered during slow‐wave sleep over one night was effective for enhancing SWA in individuals with aMCI. Given established relationships between SWA and memory, a larger or more prolonged enhancement may be needed to consistently improve memory in aMCI.