bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffuse pollution monitoring and modelling of small urban watershed in Brazil Cerrado
Authors: Tsuji T. M. , Costa M. E. L. , Koide S. 
Published: June 2019

Abstract
The stormwater runoff carries different pollutants that can reduce the quality of receiving waters due to diffuse pollutant loads. This research was aimed at evaluating the concentration of pollutants in stormwater and the application of SWMM (Storm Water Management Model) to an urban catchment in Lake Paranoá watershed to carry out the simulation of flow discharge with the hydraulic model, and subsequently to estimate the loads conveyed to the lake in ordinary events of precipitation. This study was carried out based on rainfall and runoff monitoring during events. It was confirmed that this model's results fit well in simulation of this type of watershed, leading to high value of the Nash–Sutcliffe coefficient after calibration but, as expected, precipitation distribution is a very important factor for calibration. Concerning water quality, it was observed that the event mean concentration values of suspended solids and chemical oxygen demand were high, indicating that the diffuse pollution is an important source of pollution of the receiving waters. The monitoring and modelling of stormwater are essential to identify diffuse pollution discharge, in searching for a sustainable solution.
Various factors contributive toward tourist intention in enjoying wellness tourism
Authors: Wendri I Gusti Made , Bakta I Made , Suprapti Ni Wayan Sri , Ardika I Wayan 
Published: June 2019

Wellness tourism is fast growing nowadays as alternative tourism developed from conventional spa tourism into special-interest tourism. Therefore, it is interesting to study the phenomenon of this fast developing industry in Bali in order to reveal its advantage for one’s wellness on the basis of the following question: What factors are contributive to the tourists’ intention in enjoying wellness tourism?. This study aims to explore the factors of belief-forming the tourists’ intention or interest to enjoy wellness tourism. The research adopts planned behavior theory (PBT) as its theoretical framework. The data was collected by questionnaires distributed to 100 tourist-respondents accessed by purposive sampling technique. The analysis was quantitatively done using factor analysis technique as a data analytical instrument. The result of the analysis shows that there are 8 belief factors identified to form the tourists’ intention in enjoying wellness tourism. These factors include: 1) the belief in spa’s benefit, 2) price, 3) past experience, 4) moral obligation for health, 5) environmental awareness, 6) personal value, 7) socializing program and 8) health maintenance. It is hoped that this research result would provide valuable information for the development of wellness tourism in Bali.
Textos vencedores do Concurso Literário de 2011
Authors: Benvenuti Juçara 
Published: June 2019

O Concurso Literário do Colégio de Aplicação é uma Ação de Extensão realizada anualmente pelo Departamento de Comunicação com o objetivo de estimular a produção escrita e de registrar as memórias da comunidade escolar. Em 2011 foi realizado de abril a julho, envolvendo a participação de vários professores dos diferentes departamentos do CAp, uma professora do Instituto de Letras da UFRGS, um técnico-administrativo. Os textos premiados aqui divulgados são identificados pelos autores através de seus nomes e pseudônimos usados na inscrição.
Aproximações entre trabalho e educação na América Latina e no mundo
Authors: Morigi Valter 
Published: June 2019

O artigo trabalha os pontos de convergência entre educação popular, a questão do trabalho e a educação. Parte do histórico do trabalho no capitalismo como conhecemos hoje para afirmar a economia solidária enquanto uma alternativa possível de ser apontada como política pública, numa realidade na qual o trabalho é supervalorizado e todo ócio é condenado.Defende a necessidade de transformação, para que os habitantes das cidades do mundo articulem ações e propostas que permitam melhor fazer frente aos novos desafios do mundo do trabalho, dando a todas as pessoas oportunidades de desenvolvimento e crescimento individual e coletivo.
Letramento, Desejo e Prática no Contexto do Ciclo de Alfabetização; a Atuação do Programa de Formação Continuada (PNAIC) em Goiás.
Authors: Marques Myriam 
Published: June 2019

RESUMO: Este estudo busca investigar como vem sendo desenvolvido o processo de domínio da leitura e da escrita no ciclo de Alfabetização proposto na Lei 11.274, de 06/02/2006, que altera os artigos 32 e 87 da LDB, Lei nº 9.394 de 20/12/1996, instituindo a ampliação do ensino fundamental para nove anos de duração. Propõe uma reflexão sobre a compreensão dos processos de alfabetização e letramento, e contempla o Curso de Formação para Professores Alfabetizadores denominado PNAIC (Programa Nacional pela Alfabetização na Idade Certa) em Goiás. Aborda ainda a intencionalidade do mesmo quanto à consolidação da prática da leitura e escrita dentro do prazo que se estabeleceu para que todas as crianças possam estar alfabetizadas. Aborda também a atuação desejosa e comprometida dos professores para que estes possam atribuir significado e autonomia no processo de assimilação de diferentes saberes minimizando a problemática que se percebe quanto ao fracasso escolar Palavras- chave: Alfabetização. Letramento. Desejo. Prática docente
Uma aluna da EJA atuando como bolsista de IC Júnior: relato de uma experiência
Authors: Bernardo Odete De Oliveira , Bocasanta Daiane Martins 
Published: June 2019

O trabalho apresenta um relato escrito por uma aluna da EJA de 50 anos acerca de sua experiência como bolsista de IC-Júnior em uma pesquisa cujo objetivo foi identificar e analisar como estudantes da Educação de Jovens e Adultos (EJA) são posicionados em livros didáticos voltados para a alfabetização e pós-alfabetização em relação ao que consideramos conhecimentos tecnocientíficos.
1458-P: Dietary Patterns and Genetic Factors in Relation to Metabolic Syndrome Risk in Whites and African Americans: A Longitudinal Aric Study
Authors: HARDY DALE S. ,   CVD PRIDE GROUP
Published: June 2019

We determined whether longitudinal changes in MetS were influenced by interaction between a genetic risk score (GRS) and habitual dietary patterns among whites and African Americans. We used the Atherosclerosis Risk in Communities study data from 4-visits (1987-1998) for 9,778 whites and 2,922 African Americans aged 45-65y at baseline. MetS was defined according to the NCEP, Adult Treatment Panel III criteria. Dietary variables were obtained from the Atherosclerosis Risk in Communities study food frequency questionnaire. Generalized linear models using risk ratios (RR) and 95% confidence intervals (CI) with p &lt; 0.05 were used to judge model statistical significance. For every 5-allele increase, the GRS was associated with increased risk for MetS in whites (RR=1.12;95% CI=1.11-1.13) and African Americans (RR=1.16;1.14-1.19), respectively. Those in the upper half of the GRS had 1.20-fold (RR=1.20;1.18-1.23) and 1.25-fold (RR=1.25;1.20-1.29) increased risk for MetS among whites and African Americans, respectively. For every 5-unit increase in factor scores for dietary patterns: Red/processed meat (RR= 1.13;1.09-1.18), skim milk/lowfat dairy (RR=1.11;1.06-1.17), high-fat dairy/butter (RR=0.95;0.90-100), and high carbohydrate foods (RR=1.20;1.14-1.27) were associated with longitudinal changes in MetS among whites. Dietary pattern with whole milk/high fat dairy was protective in MetS among African Americans (RR=0.81;0.72-0.90) but the dietary pattern characterized by red processed meat was harmful (RR=1.16;1.08-1.25). In interaction models, among whites, a protective risk remained for high-fat dairy dietary pattern after interaction with the risk-causing GRS (RR=0.85;0.75-0.96). Certain dietary patterns may be associated with MetS. However, the effect of a higher fat intake dietary pattern may be protective of MetS among whites and African Americans even with a high burden of risk-causing alleles among whites.

Disclosure
D.S. Hardy: None.

Funding
National Heart, Lung, and Blood Institute (K01HL127278)
146-LB: Efficacy and Safety of Metformin Glycinate vs. Metformin Hydrochloride in Metabolic Control and Inflammatory Mediators in Type 2 Diabetes Mellitus Patients (T2DM)
Authors: GONZÁLEZ-CANUDAS JORGE ,   COMET GROUP
Published: June 2019

Background: Metformin Glycinate (MG) is a recently developed drug with a different pharmacokinetic profile compared to Metformin Hydrochloride (MH); it also has additional signaling pathways to control hyperglycemia.
Objective: To compare efficacy, safety and effect on inflammatory mediators of MG versus MH treatment over 12 months in T2DM patients. Clinical Trials.gov: NCT01386671.
Methods: Controlled, randomized, double blind, multicenter. Group A was treated with 1,700 mg/day of MH and Group B with 2,101.2 mg/day of MG. Milliplex Map Human Cyokine, commercial ELISA kit, was used to determinate the following pro-inflammatory mediators: TNF-α, IL-1 β, IL-6, ICAM-1, VCAM-1, CRP and anti-inflammatory mediator: adipokine.
Results: 203 patients were randomized, 101 (Group A) and 102 (Group B). 144 patients had complete for inflammatory mediators evaluation, 73 in Group A and 71 in Group B. There were no differences in mean HbA1c and fasting glucose between groups. In Group B a bigger proportion of patients achieved the goal of HbA1c 7%, p= 0.030; each intra-group showed statistical decrease differences in pro-inflammatory mediators, p&lt;0.05 and increase adiponectin levels, p&lt;0.05. After six months, only 76% of patients in Group A achieved normal levels of leptin versus 91% in Group B (p=0.022). QUICK were evaluated to determine insulin resistance, in Group B at 6 months had higher decrease resistance (p=0.040). There were fewer treatment emergent adverse events in Group B (p= 0.03).
Conclusion: There were no differences in efficacy between groups (HbA1c). The difference on inflammatory mediators’ response was statistically significantly different after 6 months of treatment. There was higher proportion of patients treated with Metformin Glycinate with normal levels in leptin and resistin, which could be related to a lower insulin resistance (QUICK). Metformin Glycinate group showed a better safety profile.

Disclosure
J. González-Canudas: Employee; Self; Laboratorios Silanes.

Funding
CONACyT; Laboratorios Silanes
1489-P: Ten-Year Follow-Up of Diabetes Incidence in the DE-PLAN (Diabetes in Europe—Prevention Using Lifestyle, Physical Activity, and Nutritional Intervention) Project in Catalonia
Authors: BARRIO FRANCISCO , COSTA BERNARDO , COS FRANCESC XAVIER , CABRE JOAN-JOSEP , MARTINEZ ANNA , MESTRE SANTIAGO , CASTELL CONXA , LINDSTROM JAANA ,   THE CATALAN DIABETES PREVENTION RESEARCH GROUP
Published: June 2019

To assess the long-term effectiveness of a pragmatic public healthcare strategy to prevent type 2 diabetes within primary care setting. In the extended follow-up of the DEPLANCAT project, we explored whether the originally-achieved risk reduction remains after discontinuation of active lifestyle intervention. Middle-aged men (n=184) and women (n=368) with Finnish Diabetes Risk Score (FINDRISC)&gt;14 and/or prediabetes (WHO rules for fasting or 2-h glucose) were allocated not randomly but sequentially to standard care control (CG) or intensive lifestyle intervention (IG) group. After a median of 4.2 y of active intervention, participants who were still free of diabetes were further followed-up without any additional specific intervention for a median of 5.8 y (median total follow-up of 10.01 y) via computerized health-care records or direct personal contact with invitation to 2h-glucose retest. The primary outcome was the development of diabetes. During the active intervention, diabetes was diagnosed in 124 participants (22.5%): 63 (28.8%) in the CG and 61 (18.3%) in the IG. After 10 y, 27 people (4.9%) had died. Among the remaining 401 individuals, 34 diabetes diagnoses were traced using the health-care records. Additionally, among the 191 people (47.6%) who agreed to blood re-test (66 in the CG and 125 in the IG) 16 new cases were found. During the post-intervention follow-up the total number of new cases of diabetes was 16 in the CG and 34 in the IG. The absolute incidences of diabetes during the overall follow-up were 6.1 (95% CI 5.2-6.9) and 5.1 (4.4-5.8) per 100 person-years, respectively (p=0.019 log-rank). The corresponding HR was 0.59 (0.43-0.81) with a relative risk reduction of 16.6%. The NNT to prevent one case of diabetes was 10. Intensive lifestyle intervention in a primary care setting substantially reduces diabetes incidence among high-risk individuals. Risk reduction can persist for at least 10 years.

Disclosure
F. Barrio: None. B. Costa: None. F. Cos: None. J. Cabre: None. A. Martinez: None. S. Mestre: None. C. Castell: None. J. Lindstrom: None.

Funding
Institute of Health Carlos III, Spanish Ministry of Health and the European Regional Development Fund (PI14/00122, PI14/00124); La Marató de TV3 Foundation (73-201609.10); Spanish Diabetes Society; Department of Health, Generalitat de Catalunya; Pla Estratègic de Recerca i Innovació en Salut (SLT002/16/00045, SLT002/16/00154, SLT002/16/00093)
1501-P: Reproducibility of Glycemic Measures among Youth and Adults with Impaired Glucose Tolerance (IGT) or Recently Diagnosed Type 2 Diabetes (T2D) in the Restoring Insulin Secretion (RISE) Study
Authors: TJADEN ASHLEY H. , EDELSTEIN SHARON , ARSLANIAN SILVA A. , BARENGOLTS ELENA , CAPRIO SONIA , CREE-GREEN MELANIE , LTEIF AMALE A. , MATHER KIEREN J. , SAVOYE MARY , XIANG ANNY , KAHN STEVEN E. ,   RISE CONSORTIUM
Published: June 2019

Fasting and 2-h OGTT glucose along with HbA1c are used in clinical practice for diagnosing IGT and T2D, and in clinical trials for assessing eligibility. While previous studies found poor reproducibility of such measures in adults and youth at risk for dysglycemia, no studies have assessed group differences in reproducibility. We assessed reproducibility of glycemic measures in treatment-naïve youth and adults screened for RISE. Central laboratory measurements of plasma glucose and HbA1c from two standardized 2-h OGTTs completed 4 weeks apart were compared in 66 youth (mean age 14.2 y) and 354 adults (52.7 y) with IGT or recently diagnosed T2D, using ADA criteria. Between screening and baseline, mean coefficient of variation (CV) was lowest for HbA1c in both groups (Table). HbA1c variability was greater in youth than adults, whereas 2-h glucose variability was greater in adults. Status concordance was highest with HbA1c and lowest with 2-h glucose alone, and significantly lower in youth than adults using HbA1c alone. This variability produced discordant glycemic classification at screening vs. baseline in over 25% of participants. The variability and lack of classification concordance in youth and adults highlights the limitations of one-time testing for diagnostic classification in clinical practice and trials.

Disclosure
A.H. Tjaden: None. S. Edelstein: None. S.A. Arslanian: None. E. Barengolts: None. S. Caprio: None. M. Cree-Green: None. A.A. Lteif: None. K.J. Mather: Advisory Panel; Self; Roche Diabetes Care. Research Support; Self; Abbott, Merck & Co., Inc., Novo Nordisk A/S, Sanofi. M. Savoye: None. A. Xiang: None. S.E. Kahn: Advisory Panel; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Intarcia Therapeutics, Inc., Janssen Pharmaceuticals, Inc., Merck & Co., Inc., Novo Nordisk A/S. Consultant; Self; Neurimmune. Other Relationship; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Merck & Co., Inc., Novo Nordisk A/S. R. Consortium: None.

Funding
American Diabetes Association (1-14-RISE-01 to S.E.K.); National Institute of Diabetes and Digestive and Kidney Diseases
1540-P: Plasma Advanced Glycation End Products (AGEs) at Three Time Points during the DCCT/EDIC Are Associated with Subsequent Risk of Microvascular Complications in Type 1 Diabetes
Authors: MONNIER VINCENT M. , SELL DAVID , LACHIN JOHN , BEBU IONUT ,   THE DCCT/EDIC RESEARCH GROUP
Published: June 2019

We previously showed that skin collagen AGEs at DCCT trial closeout were strongly associated with progression of microvascular disease even after adjustment for A1c (Glyconj. J. 33: 569, 2016). We now tested whether plasma protein AGEs are associated with subsequent progression of retinopathy, nephropathy and neuropathy.
Methods: Fourteen AGEs were measured by LC/MS/MS in banked plasmas from 466 DCCT participants at three time points (TPs): DCCT year 4 (TP1), year 8 (TP2) and EDIC year 5/6 (TP3). Data were analyzed using correlation coefficients, while associations with risk of complications used Cox proportional hazards models were determined without adjustment for multiplicity.
Results: Fructose-lysine (FL), glucosepane (GSPN) and carboxymethyl-lysine (CML) were lower in the former intensive glycemic control group at both TP1 and TP2 (P&lt;0.0001) but not at TP3. At all 3 TPs, mean A1C was positively correlated with levels of FL (r=0.44), GSPN (r=0.33) and CML (r=0.35). In unadjusted Cox models using all three TPs, higher levels of FL, GSPN and CML were associated with subsequent risk of proliferative diabetic retinopathy (PDR, P&lt;0.0001), clinically significant macular edema (CSME, P&lt;0.0008) and confirmed clinical neuropathy (CCN, P&lt;0.005). After adjustment for mean A1C, all three AGEs (FL, GSPN, CML) remained significantly associated with PDR (P&lt;0.021), FL and GSPN remained significant for CCN (P≤0.005), and CML remained significant for CSME (P=0.033). Methylglyoxal hydroimidazolone (MG-H1) and methionine sulfoxide (MetSOX) were positively associated with sustained eGFR&lt;60 and cardiac autonomic neuropathy before and after adjustment for A1C (P&lt;0.05, P=0.031, respectively).
In conclusion, after adjustment for A1C, FL, GSPN, CML and MG-H1 are the plasma AGEs most strongly associated with progression of microvascular complications in type 1 diabetes.

Disclosure
V.M. Monnier: Consultant; Self; Juvenescence Ltd. D. Sell: None. J. Lachin: Board Member; Self; Tolerion, Inc. I. Bebu: None.

Funding
National Institute of Diabetes and Digestive and Kidney Diseases (DP3DK101123-01)
1541-P: Association between Urine Free Advanced Glycation End Products (AGEs) at Three Time Points during the DCCT/EDIC and Subsequent Risk of Microvascular Complications in Type 1 Diabetes
Authors: SELL DAVID , LACHIN JOHN , BEBU IONUT , MONNIER VINCENT M. ,   THE DCCT/EDIC RESEARCH GROUP
Published: June 2019

Using banked urines from 156 DCCT participants of the former skin biopsy cohort (Diabetes 48:870,1999) we tested whether free AGEs measured at DCCT year 4 (Timepoint TP1), year 8(TP2) and EDIC year 17 (TP3) are associated with risk of microvascular complications progression.
Methods: Fructose-lysine(FL), glucosepane(GSPN), carboxymethyl-lysine(CML), methylglyoxal (MG-H1) and 10 other markers were measured by LC/MS/MS. Data were analyzed using correlation coefficients, while associations with risk of complications using Cox proportional hazards (PH) models without adjustment for multiplicity.
Results: FL (P&lt;0.005) and GSPN (P&lt;0.004) were significantly lower in the intensive therapy group at TP2. At all 3 TPs, mean A1C correlated with FL (r=0.31) and GSPN (r=0.30) (P&lt;0.0001). In unadjusted Cox PH models, higher GSPN levels were associated with sustained eGFR&lt;60 (P=0.007), cardiac autonomic neuropathy (CAN) (P=0.008) and borderline with confirmed clinical neuropathy (CCN) (P=0.05, NS). FL and CML were associated with sustained microalbuminuria (SA) both before (P≤0.001, 0.012) and after (P≤0.034) adjustment for A1C. Upon adjustment for A1c, age and gender using all 3 TPs, methionine sulfoxide/MetSOX (P=0.001), 3-nitrotyrosine (P=0.003), and FL and G-H1 (P&lt;0.027) were associated with PDR; pentosidine (P=0.041) with clinically significant macular edema; MetSOX (P=0.013) and GSPN (P&lt;0.034) with sustained eGFR&lt;60; FL (P=0.015), CML (P=0.028) and MG-H1 (P=0.042) with SA. LW-1/glucuronidine was associated with CCN both before (P&lt;0.001) and after adjustment for A1C (P&lt;0.001). Chi square statistics were larger than A1c for GSPN with CAN, MetSOX with sustained eGFR&lt;60 and LW-1/glucuronidine for CCN, suggesting stronger associations.
Conclusions: FL, GSPN, and CML in urine consistently emerge as the AGEs most significantly associated with risk of subsequent microvascular complications.

Disclosure
D. Sell: None. J. Lachin: Board Member; Self; Tolerion, Inc. I. Bebu: None. V.M. Monnier: Consultant; Self; Juvenescence Ltd.

Funding
National Institute of Diabetes and Digestive and Kidney Diseases (DP3DK101123)
1722-P: Colocalization of TOPMed Whole Genome Sequencing Analysis and Tissue-Specific eQTL Signals Detects Target Genes for Type 2 Diabetes Risk
Authors: SZETO MINDY D. , HIGHLAND HEATHER M. , MANNING ALISA ,   TOPMED DIABETES WORKING GROUP
Published: June 2019

Type 2 diabetes (T2D) risk is highly heritable, and although many associated loci have been identified, analyses of regulatory regions in most whole-genome sequencing (WGS) studies have not been specific to relevant tissues. The availability of tissue-specific expression quantitative trait (eQTL) information can further elucidate the functional role of non-coding regulatory variants. A WGS (&gt;38x sequencing depth) association study was performed for variants in 9,663 cases and 35,050 controls from the NHLBI’s Trans-Omics for Precision Medicine (TOPMed) program. eQTL data from 48 different tissues was obtained from the Genotype-Tissue Expression (GTEx) Portal. To generate loci of interest, 200-kb windows were considered upstream and downstream of each variant found to be genome-wide significant (p &lt; 5x10^-8) in both the TOPMed and GTEx datasets. A total of 11 regions in different tissues were significantly associated with T2D status, centered around variants such as rs6585201 in the ascending aorta (TCF7L2, TOPMed p = 1.18x10^-9, GTEx p = 1.12x10^-10, but did not localize to the strongest signal in the region), rs76895963 in the cerebellum (CCND2, TOPMed p = 3.51x10^-9, GTEx p = 4.40x10^-17), and rs4898431 in ovarian tissue (DUSP9, TOPMed p = 1.88x10^-8, GTEx p = 4.39x10^-8). We plan to implement eCAVIAR to examine causal variant colocalization, with the advantages of leveraging summary statistics and accounting for the possibility of more than one causal variant per locus. These results confirm previously published studies, but provide validation of methods we will extend to larger samples and diabetes-related outcomes.

Disclosure
M.D. Szeto: None. H.M. Highland: None. A. Manning: None.

Funding
National Institute of Diabetes and Digestive and Kidney Diseases (U01DK078616, K01DK107836)