bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships between different trends of the Mediterranean diet and cardiovascular disease-related risk factors in China: results from the CHNS study, 1997–2009
Authors: Bao Zhengyang , Qian Zhengtao , Chen Jiale , Chen Yu , Li Na , Ye Yang , Ren Yongwei , Tang Yiming , Chen Daozhen 
Published: November 2024

ObjectivesThe present study aimed to explore the associations between Mediterranean diet trajectories (MDTs) and cardiovascular disease-related risk factors in Chinese adults.MethodsA total of 4,332 participants from the China Health and Nutrition Survey (CHNS) were included in this study. A group-based trajectory model (GBTM) was used to explore Mediterranean diet trajectories (MDTs). Linear regression analyses were conducted to assess the association between Mediterranean diet trajectories and cardiovascular disease-related risk factors. Stratified analyses by gender were also performed.ResultsThe following four groups were identified in the total population: Group 1 (Persistently low MDT, n = 292, 6.74%), Group 2 (Descent MDT, n = 537, 12.40%), Group 3 (Ascent MDT, n = 454, 10.48%), and Group 4 (Persistently high MDT, n = 3,049, 70.38%). Compared to the persistently low MDT (Group 1), both Group 2 and Group 4 were negatively related to low-density lipoprotein cholesterol (LDL-C) (Group 2: β = −0.23, 95% CI: −0.36 to −0.09, p = 0.001; Group 4: β = −0.25, 95% CI: −0.37 to −0.14, p &lt; 0.001), total cholesterol (TC) (Group 2: β = −0.18, 95% CI: −0.32 to −0.04, p = 0.010; Group 4: β = −0.31, 95% CI: −0.43 to −0.19, p &lt; 0.001), and uric acid (UA) (Group 2: β = −15.16, 95% CI: −28.66 to −2.56, p = 0.019; Group 4: β = −27.51, 95% CI: −38.77 to −16.25, p &lt; 0.001) after adjusting for potential risk factors. Only Group 4 exhibited a negative relationship with triglycerides (TG) (β = −0.18, 95% CI: −0.34 to −0.02, p = 0.028) and blood glucose (β = −0.19, 95% CI: −0.37 to −0.02, p = 0.032).ConclusionFour MDTs were identified among the total participants, including men and women. These trajectories were summarized as persistently low MDT, ascent MDT, descent MDT, and persistently high MDT. Adherence to high MDTs could reduce the level of some CVD-related risk factors. The impact of the remote MD on CVD-related risk factors may be greater than that of the proximal MD.
Diving into hot topics of salivary gland carcinoma management—an EORTC young and early career investigator survey
Authors: Lorini Luigi , Ronchi Sara , Nevens Daan , Klinghammer Konrad , Orlandi Ester , Bossi Paolo , Szturz Petr 
Published: November 2024

IntroductionRecently, the ASCO and ESMO guidelines on salivary gland carcinomas (SGCs) have been released. However, several crucial points lack strong recommendations due to low or intermediate quality of evidence. To better address these “grey zones” in the guidelines, we conducted a survey among the European Organization for Research and Treatment of Cancer (EORTC) Head and Neck Cancer Group (HNCG) members on behalf of the EORTC young and early career investigators.Materials and methodsThe survey included 29 questions addressing diagnostic and therapeutic issues related to SGC patients and was shared among 539 members of the EORTC HNCG. Responses were collected from December 2022 to March 2023. The primary aim was to evaluate the decision-making criteria guiding physicians in areas with low evidence in SGC guidelines.ResultsWith a response rate of 19%, the survey received input from 102 respondents, mainly medical oncologists (45%). Among those with pathological high-risk features, 35% and 30% of respondents opted for chemoradiotherapy (CRT) in the definitive and adjuvant settings, respectively. For patients with R0 resection of highly aggressive SGC at the pT1–2 stage, 37% proposed a close follow-up, while 38% proposed adjuvant lymph-node field RT. In cases of pT3–4 stage, 48% proposed adjuvant lymph-node field RT in all cases, and 44% proposed it based only on risk factors. The most important factors guiding the decision to give adjuvant RT after salvage surgery for locoregional relapse include previous radiotherapy, margin status, and the presence of extranodal extension. When faced with combined positivity to HER2 and AR, responses regarding the choice of first-line palliative treatment were heterogeneous.ConclusionsInternational guidelines lack strong recommendations in several fields of SGC diagnosis and treatment due to insufficient high-quality data, resulting in heterogeneity in physicians’ treatment decision (e.g., adjuvant lymph-node field RT and their low concordance with guidelines, such as the use of concomitant CRT). The survey demonstrated the need for prospective clinical trial data to address these gaps in the future.
Prognostic characteristics and drug sensitivity analysis of hepatocellular carcinoma based on histone modification-related genes: a multi-omics integrated study revealing potential therapeutic targets and individualized treatment strategies
Authors: Sun Ping , Ding Zheng , Chen Juan , Ou Kezhen , Zhou Dianjie , Li Rui , Gu Tianxiang , Sun He , Cheng Ying 
Published: November 2024

BackgroundHepatocellular carcinoma (HCC) ranks among the most prevalent and lethal malignancies worldwide. Histone modifications (HMs) play a pivotal role in the initiation and progression of HCC. However, our understanding of HMs in HCC remains limited due to the disease’s heterogeneity and the complexity of HMs.MethodsWe integrated multi-omics data from multiple cohorts, including single-cell RNA sequencing, bulk RNA sequencing, and clinical information. Weighted gene co-expression network analysis (WGCNA) and consensus clustering were employed to identify histone-related genes. We developed a histone modification-related signature (HMRS) using 117 machine learning methods. Comprehensive analyses of molecular characteristics, immune landscape, and drug sensitivity associated with the HMRS were performed.ResultsThrough integrative analysis, we defined 110 histone-related genes and identified 45 HCC-HM-related genes (HCC-HMRgenes). The HMRS demonstrated robust prognostic value across multiple cohorts. Patients with high HMRS scores exhibited distinct genomic alterations, including higher tumor heterogeneity and TP53 mutations. The high-risk group showed enrichment in cell cycle, DNA repair, and metabolic pathways. Immune landscape analysis revealed significant differences in immune cell infiltration and pathway activities between high- and low-risk groups. Drug sensitivity prediction suggested potential therapeutic strategies for different risk groups.ConclusionOur study provides a comprehensive understanding of HMs in HCC and establishes a robust prognostic signature. The HMRS not only stratifies patients into distinct risk groups but also offers insights into underlying molecular mechanisms, immune characteristics, and potential therapeutic strategies, paving the way for personalized medicine in HCC.
Evaluating the impact of rock climbing on mental health and emotional well-being in adolescents
Authors: Gürer Hüseyin , Akçınar Faruk , Arslan Semiha Cömertoğlu , Akçınar Serpil , Güllü Mehmet , Eken Özgür , Kurtoğlu Ahmet , Ilkım Mehmet , Alotaibi Madawi H. , Elkholi Safaa M. 
Published: November 2024

BackgroundRock climbing (RC) has gained attention as a therapeutic tool in psychiatric settings that merges physical exertion with mental engagement. It has potential to enhance mental health, through improved self-efficacy and social interaction, making it a novel intervention for addressing anxiety, depression, and behavioral issues in adolescents. This study aimed to investigate the effects of RC as a physical activity on anxiety, depression, and emotional and behavioral problems in adolescents.MethodsThe current study included 57 athletes aged 14.5 ± 1.7 years and 91 adolescents aged 13.6 ± 1.2 years, matched for age and gender, who were not professionally involved in sport. In addition to the socio-demographic form, a detailed psychiatric assessment was carried out by the child psychiatrist; using the Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime Version (K-SADS-PL) to detect psychiatric conditions. The Revised Child Anxiety and Depression Scale-Child Version (RCADS-CV) and the Strengths and Difficulties Questionnaire (SDQ) were also administered to the adolescents in the study.ResultsIn the comparative analysis of the RCADS-CV outcomes between the athlete and control groups, the athletes demonstrated notably lower scores for both Separation Anxiety Disorder (SAD) and Generalized Anxiety Disorder (GAD), yielding p-values of &lt; 0.001 and 0.031, respectively. Although the mean scores for social phobia, OCD, panic disorder, and MDD were lower in the athlete group, the differences were not statistically significant (p &gt; 0.05). In the correlation analysis, a moderately significant correlation was found between the duration of doing sport and the scale scores for SAD (p:0.010), OCD (p:0.014), and panic disorder (p:0.016). There was no significant difference between groups in terms of SDQ scores.ConclusionThese results suggest that RC, through its unique combination of physical exertion and mental focus, may offer protective benefits against certain anxiety disorders among adolescents. Further studies should be conducted to explore the potential use of RC as a preventive program for both healthy adolescents, as well as those with psychiatric disorder.
Beyond accreditation: unraveling the narrative of public health through a critical race praxis lens
Authors: Collins Sarah L. , Allen-Mitchell Acquel , Smith Travis C. , Hack George , Stetten Nichole E. , Moorhouse Michael D. 
Published: November 2024

IntroductionRecognizing and addressing health inequities among minority populations are pivotal to public health. Further, public health strives to understand the complexities between race and health without limiting discussions around race as a trivial variable. This commitment toward equity demonstrates considerable similarities to Critical Race Theory (CRT) which led to the creation of the Public Health Critical Race (PHCR) Praxis to instill CRT within public health. However, the literature on how public health education incorporates critical race studies remains limited. The goal of this study was to examine how public health curriculum currently aligns with the PHCR praxis and meets public health's goal of health equity.MethodsThis qualitative study employed document analysis to evaluate academic syllabi from CEPH-accredited MPH programs. Stratified random sampling was applied across two sampling pools, Schools of Public Health (SPH), and Public Health Programs (PHP). Course overviews, course objectives, course curricular information, and course policies were identified and extracted from each syllabus for analysis. A total of 53 syllabi were obtained from a final sample of nine public universities and one private.ResultsThrough inductive and directed content analysis, a priori themes of Structural Determinism, Voice, Critical Approaches, Ordinariness of Racism, Social Construction of Knowledge, Intersectionality, Disciplinary Self-Critique, Primacy of Racialization, Race as a Social Construct, Race Consciousness, and their respective categories arose as salient. Two new themes, Antiracism Practices and Culture of Inclusivity, were also present.DiscussionThis study is the first to explore public health education's current curricular practices concerning CRT and antiracist praxes. The results confirm the interwoven nature of public health education with critical race studies, as all principles of PHCR praxis were present. However, the prevalence of these principles varied, suggesting gaps in the alignment of public health curricula and CRT. It is essential that public health educators ensure that the foundational competencies students are expected to display align with public health's goal of health equity. This work can equip MPH programs and public health educators with the ability to revise or bolster their current curricular and instructional efforts to support the pursuit of health, racial equity, and social justice.
A comparative study of antenatal depression among urban and rural pregnant women in Gimbi District, Oromia, Ethiopia
Authors: Chala Solomon , Desalegn Markos , Oljira Rut , Fite Meseret Belete , Mecha Sagni Hambisa , Hunde Gemechis Megnaka 
Published: November 2024

BackgroundAntenatal depression (AND) is a form of clinical depression that can be caused by stress and worries that can bring pregnancy to more severe levels. It has negative impacts on women, the family, and the community at large. The comparative study of antenatal depression among rural and urban pregnant women was less studied in Ethiopia and in this study area in particular.ObjectiveThe objective of the study was to compare the prevalence of antenatal depression and its associated factors among pregnant women in Gimbi rural and urban residents in Ethiopia in 2023.MethodsA community-based comparative cross-sectional study design was used from 1 February to 30 March 2023. A systematic random sampling method was used to select study participants. Data were collected using pretested interviewer-administered structured questionnaires. Binary logistic regression analysis was used to identify factors associated with antenatal depression. Variables with a p-value of 0.25 or less in the bi-variable logistic regression model were candidates for a multi-variable logistic regression model.ResultsThe prevalence of antenatal depression was 56 (21.5%), 95% CI: [16.9–25.5] among rural participants and 50 (19.2%) [95%] CI: [14.6–23.8] among urban participants. Having complications during pregnancy (AOR: 4.92, 95% CI: 1.35, 17.88), ever had depression (AOR: 3.20, 95% CI: 1.30, 7.85), consuming alcohol (AOR: 3.78, 95% CI: 1.24, 11.49), and educational status (can read and write) (AOR: 2.14, 95% CI:1.05, 4.67) were factors associated with antenatal depression among urban mothers, while no antenatal care follow-up (AOR: 6.6, 95% CI: 2.63, 16.85), unplanned pregnancy (AOR: 4.51, 95% CI:1.10, 1.86), and having complications during pregnancy (AOR: 2.77, 95% CI: 1.30, 5.92) were factors associated with antenatal depression among rural mothers.ConclusionThe prevalence of antenatal depression among rural mothers was higher than the prevalence of antenatal depression among urban mothers in the Gimbi district. Having complications during pregnancy, ever had depression, consuming alcohol, and educational status were associated factors with antenatal depression among urban mothers; having complications during pregnancy, unplanned pregnancy, and no ANC follow-up were factors associated with antenatal depression among rural mothers. Therefore, quality family planning and ANC services should be provided for the women to reduce unplanned pregnancies and experience complication-free pregnancy periods.
How supermarket retailers value business outcomes of healthy food retail strategies: a discrete choice experiment
Authors: Alsubhi Moosa , Blake Miranda R. , Livingstone Ann , Moodie Marj , Ananthapavan Jaithri 
Published: November 2024

BackgroundSupermarkets are businesses, and any voluntary changes to increase the healthiness of their food offerings must align with retailers’ commercial needs. Business outcomes of healthy food retail strategies are important non-health factors that may influence retailers’ decisions to implement these strategies. Although there is growing evidence on the significance of various business outcomes, such as net profit and customer satisfaction, it remains unclear how retailers value and trade-off these outcomes against each other. This study aimed to determine retailer preferences and measure their marginal willingness to pay for key business outcomes.MethodsA Discrete Choice Experiment (DCE) survey recruited current or former owners or managers of supermarkets or grocery stores in Australia. It included 12 choice tasks for two hypothetical scenarios (A or B) that the retailer could implement in their store, along with an option to maintain the current situation (opt-out option). The survey included six attributes (net profit, healthy items sold, customer and retailer satisfaction, ease and costs of implementation) with 3–4 levels each. A multinomial logit model was used to estimate preferences and calculate marginal rates of substitution and marginal willingness to pay.ResultsSixty-one respondents completed the DCE, resulting in a 72% response rate. Retailers identified customer satisfaction as the highest ranked business outcome when deciding to implement healthy food retail strategies. This was followed by the percentage of healthy items sold, supplier satisfaction, net profit, implementation cost, and ease of implementation. The marginal willingness to pay for different attribute levels varied from A$650 per year per store for a strategy that increases net profit by 3% to A$32,136 for a strategy leading to “very satisfied” levels of customer satisfaction compared to the base level.ConclusionThe results could be used to guide the implementation of healthy food retail strategies that also meet the needs of retailers.
Androgyny and atypical sensory sensitivity associated with savant ability: a comparison between Klinefelter syndrome and sexual minorities assigned male at birth
Authors: Tawata Shintaro , Sakaguchi Kikue , Saito Atsuko 
Published: November 2024

IntroductionThe extreme male brain (EMB) theory, a major causal hypothesis of autism (ASD: autism spectrum disorder), attributes excess androgens during early development as one of the causes. While studies have generally followed the EMB theory in females at birth, the co-occurrence of ASD in males at birth has been observed in conditions that are assumed to be associated with reduced androgen action during early development, including Klinefelter syndrome (KS) and sexual minorities. ASD is also associated with atypical sensory sensitivity, synesthesia, and savant syndrome.MethodsIn the present study, we examined adult KS individuals (n = 22), sexual minorities assigned male at birth (n = 66), and control males matched for age and educational background to those with KS [Exploratory analysis (control 1st): n = 36; Reanalysis (control 2nd): n = 583]. Participants completed a self-report questionnaire assessing sensory hypersensitivity/hyposensitivity, savant tendency (developed for the present study), synesthesia, and sexual aspects, including gender identity and sexual orientation.ResultsThe results of the exploratory analysis suggested that individuals with KS exhibited a higher tendency toward sensory hypersensitivity/hyposensitivity than the tendency exhibited by the controls. In the Reanalysis, sexual minorities were more likely to be synesthetes, and in both analyses sexual minorities exhibited a higher savant tendency and sensory hypersensitivity/hyposensitivity than the controls. Moreover, the gender dysphoric state was associated with phenotypes observed in individuals with ASD, such as synesthesia, savant tendency, and sensory hypersensitivity/hyposensitivity.DiscussionThese results suggest a common physiological background among gender dysphoria, synesthesia, savant tendency, and atypical sensory sensitivity. Thus, androgynous features (reduced effects of sex steroids during early development) in males at birth may be partially related to the phenotype commonly observed in individuals with ASD. Based on the present results, we propose that the reduction of sex steroids during early development may lead to atypical neurodevelopment and be involved in the atypicality of external and internal sensory perception, and thus in the atypicality of self-concept integration, through the disruption of oxytocin and the gamma-aminobutyric acid system modulating the neural excitation/inhibition balance.
Post stroke aspiration pneumonia, associated factors, and treatment outcome among stroke patients admitted to Tibebe Ghion Specialized Hospital, Bahir Dar, Ethiopia
Authors: Nigus Molla Dessalegn , Sendek Ergoye Melese , Ewunetu Mulugeta Biyadgie , Cherkos Abel Belete , Yimer Awol Arega 
Published: November 2024

BackgroundPost-stroke aspiration pneumonia is a serious lung infection that occurs when stroke patients inhale food, saliva, liquid, vomit, or foreign objects. It is the leading cause of death for stroke patients worldwide, which accounts for 60% of stroke-associated deaths. Little is known about its prevalence, adverse outcomes, and determinants in Ethiopia. Therefore, this study aims to evaluate the prevalence of post-stroke aspiration pneumonia and associated factors in stroke patients admitted to the Tibebe Ghion Specialized Hospital.Methods and materialsA retrospective cross-sectional study was conducted on 242 stroke patients admitted to the neurology unit of a medical ward from January 1, 2019, to December 30, 2020. Data were collected from the patients' cards using a pre-developed data collection tool. The collected data was coded, cleaned, and entered into Epi-Info version 7.25, and then exported to SPSS 26 for further analysis. Logistic regression analyses were performed to identify factors associated with aspiration pneumonia. The adjusted odds ratio with the corresponding 95% confidence interval and a p &lt; 0.05 were noted to declare variables had a significant association.ResultsThe mean age of the patient was 61.15 ± 13.959 years with a minimum age of 21 and maximum age of 102 years. Males account for 55.8% and females for 44.2%. Out of 242 patients post-stroke aspiration pneumonia was identified in 23.1% of patients, and 55.4% of stroke patients improved, while 23.2% died from post-stroke aspiration pneumonia. The study found that having dysphagia (AOR = 3.05; 95% CI: 1.13, 8.21), feeding through a Nasogastric tube (AOR = 10.58; 95% CI: 4.58, 24.42), and a GCS level of 8–12 (AOR = 2.58; 95% CI: 1.04, 6.42) were independent predictors of post-stroke aspiration pneumonia.ConclusionThis study found a high prevalence of post-stroke aspiration pneumonia and its associated mortality. Stroke patients with dysphagia, low levels of consciousness, and those who are fed through a tube are at a higher risk of developing this condition. Therefore, it is crucial to provide special care to stroke patients with these conditions. The study also highlights the importance of assessing the practice of preventative measures for PSAP among stroke patients in this study setting.
ПРОВЕДЕНИЕ ИНФОРМАЦИОННЫХ ИССЛЕДОВАНИЙ В МЕДИЦИНЕ: СОВЕТЫ ПО СТРАТЕГИЯМ И РЕСУРСАМ ОБЗОРА ЛИТЕРАТУРЫ
Authors: К.С. Мильчаков 
Published: November 2024

В настоящей работе представлен краткий обзор законодательных рамок информационного исследования в медицине, а также проведен обзор основных ресурсов, как библиографических баз данных, так и других. Описаны различные стратегии информационного поиска, которые зависят от цели обзора (плана исследования информации и критериев включения). Настоящая статья посвящена основам процесса обзора в рамках научных исследований по медицине и оценки технологий здравоохранения.
The current paper presents a short review of the legislative frames of information study in medicine, also it was done review of essential resources as bibliographic databases as others. It is described different strategies of information search that depend on the goal of the review (the plan of information study and inclusion criteria). This paper is devoted to essentials while review process in the frame of medical scientific research and health technology assessment.
Бұл мақалада медицинада ақпараттық зерттеулер жүргізудің құқықтық негіздері туралы қысқаша шолу, сондай-ақ библиографиялық дерекқорлардың және басқа да негізгі ресурстардың шолуы берілген. Зерттеудің мақсатына (ақпараттың зерттеу жоспары мен қосу критерийлеріне) байланысты түрлі ақпарат іздеу стратегиясы сипатталған. Бұл мақалада медицина саласындағы зерттеулер мен денсаулықты бағалау технологиясын бағалаудың негізі талқыланады.