bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic literature review on working capital management – an identification of new avenues
Authors: Kayani Umar Nawaz , De Silva Tracy-Anne , Gan Christopher 
Published: July 2019

PurposeThis paper aims to provide a review of the existing literature available on working capital (WC) and working capital management (WCM).Design/methodology/approachA systematic literature review (SLR) methodology is used to review 187 articles selected from referred journals, books and international conferences for the period 1980-2017.FindingsThis comprehensive review reveals that much of the focus in the existing literature is paid on investigating the empirical relationship between WCM and firm performance. Furthermore, the attention has been paid towards studying the WC practices. The behavioural aspects, qualitative studies, survey studies and systematic theory development have been ignored in most of the prior studies. These areas have a broader scope for future research.Research limitations/implicationsThis study is based on literature review and theoretical in nature. Therefore, it does not have any empirical results.Practical implicationsSo far, a limited literature review studies have been conducted in WCM perspective. This review provides various emerging trends, which may be considered in future research for providing a deep understanding of WCM.Originality/valueThis is the first time a detailed review of WCM literature has been conducted by using SLR for the period of 1980-2017. This review will be useful for researchers, business policymaker, finance professionals and all other having direct or indirect concerns with WCM study.
Can non-CEO inside directors add value? Evidence from unplanned CEO turnovers
Authors: Krigman Laurie , Rivolta Mia L. 
Published: July 2019

Purpose
This paper aims to investigate the roles of non-CEO inside directors (NCIDs) in the new CEO-firm matching process using the context of unplanned CEO departures when immediate CEO succession planning becomes a sole board responsibility. Although critics argue that inside directors decrease the monitoring effectiveness of a board, inside directors arguably possess superior firm-specific experience and knowledge that can be beneficial during the leadership transition.

Design/methodology/approach
The authors use a comprehensive, manually collected data set of unplanned CEO departures from 1993 to 2012.

Findings
The authors find that NCIDs play an important role in the CEO transitioning process. They help firms identify qualified inside replacements and provide stability as the new permanent or interim CEO. In addition, NCIDs facilitate the transfer of information and help the new external CEOs succeed. They show that the longer the NCID stays with the company, the longer the tenure of the new CEO. They also document that the presence of NCIDs improves operating and stock performance; especially when the new CEO is hired from outside of the firm.

Practical implications
The impact of NCIDs is particularly important when the firm hires an outsider as the new CEO. These results suggest that board composition affects frictions in the CEO labor market.

Originality/value
The literature has predominantly focused on the downside of having inside directors. Too many inside directors on a firm’s board is often associated with ineffective boards and entrenchment. To the contrary, the authors focus on a potential benefit of having inside directors.
Calcium‐dependent site‐switching regulates expression of the atypical iam pilus locus in Vibrio vulnificus
Authors: Pu Meng , Storms Emily , Chodur Dan M. , Rowe‐Magnus Dean A. 
Published: July 2019

SummaryThe opportunistic human pathogen Vibrio vulnificus inhabits warm coastal waters and asymptomatically colonizes seafood, most commonly oysters. We previously characterized an isolate that exhibited greater biofilm formation, aggregation and oyster colonization than its parent. This was due, in part, to the production of a Type IV Tad pilus (Iam). However, the locus lacked key processing and regulatory genes required for pilus production. Here, we identify a pilin peptidase iamP, and LysR‐type regulator (LRTR) iamR, that fulfil these roles and show that environmental calcium, which oysters enrich for shell repair and growth, regulates iam expression. The architecture of the iam locus differs from the classical LRTR paradigm and requires an additional promoter to be integrated into the regulatory network. IamR specifically recognized the iamR promoter (PiamR) and the intergenic iamP‐iamA region (PiamP‐A). PiamR exhibited classical negative auto‐regulation but, strikingly, IamR inversely regulated the divergent iamP and iamA promoters in a calcium‐dependent manner. Moreover, expression of the c‐di‐GMP and calcium‐regulated, biofilm‐promoting brp exopolysaccharide was IamA‐dependent. These results support a scenario in which the calcium‐enriched oyster environment triggers IamP‐mediated processing of prepilin amassed in the periplasm for rapid pilin elaboration and subsequent BRP production to promote colonization.
Variations in Newspaper Coverage on Water in the U.S. Intermountain West
Authors: Flint Courtney G. , Wynn Elizabeth , Paveglio Travis , Boyd Amanda , Bullock Cathy 
Published: July 2019

AbstractWater is a salient issue in the Intermountain West of the United States (U.S.), with concerns ranging from water scarcity and drought to intermittent flooding and water quality risks. This paper investigates coverage of water issues across seven newspapers in the core of the U.S. Intermountain West region. Newspapers have the potential to set agendas and influence perceived salience of issues among consumers. The Intermountain West region shares common concerns about water supply and demand, climate change, and water quality. We investigate whether or not local daily newspaper coverage of water issues provides a more local or regional sensitivity. Findings from this exploratory study reveal differences in water coverage across local daily newspapers. The overall volume of water‐related articles differed across newspapers as did proportion of articles on specific water topics and connecting issues. Coverage of local issues was more dominant than might be expected given mass media trends, but water geography in articles extended across the U.S. and the world in every newspaper studied. Variations in newspaper coverage of water issues suggests more local nuance persists despite the experience of common water issues across the region.
Error Assessment for Height Above the Nearest Drainage Inundation Mapping
Authors: Godbout Lukas , Zheng Jeff Y. , Dey Sayan , Eyelade Damilola , Maidment David , Passalacqua Paola 
Published: July 2019

AbstractReal‐time flood inundation mapping is vital for emergency response to help protect life and property. Inundation mapping transforms rainfall forecasts into meaningful spatial information that can be utilized before, during, and after disasters. While inundation mapping has traditionally been conducted on a local scale, automated algorithms using topography data can be utilized to efficiently produce flood maps across the continental scale. The Height Above the Nearest Drainage method can be used in conjunction with synthetic rating curves (SRCs) to produce inundation maps, but the performance of these inundation maps needs to be assessed. Here we assess the accuracy of the SRCs and calculate statistics for comparing the SRCs to rating curves obtained from hydrodynamic models calibrated against observed stage heights. We find SRCs are accurate enough for large‐scale approximate inundation mapping while not as accurate when assessing individual reaches or cross sections. We investigate the effect of terrain and channel characteristics and observe reach length and slope predict divergence between the two types of rating curves, and SRCs perform poorly for short reaches with extreme slope values. We propose an approach to recalculate the slope in Manning’s equation as the weighted average over a minimum distance and assess accuracy for a range of moving window lengths.
Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset
Authors: Martini Hélène , Iacovoni Jason S. , Maggiorani Damien , Dutaur Marianne , Marsal Dimitri J. , Roncalli Jerome , Itier Romain , Dambrin Camille , Pizzinat Nathalie , Mialet‐Perez Jeanne , Cussac Daniel , Parini Angelo , Lefevre Lise , Douin‐Echinard Victorine 
Published: July 2019

AbstractAging is a major risk factor in the development of chronic diseases, especially cardiovascular diseases. Age‐related organ dysfunction is strongly associated with the accumulation of senescent cells. Cardiac mesenchymal stromal cells (cMSCs), deemed part of the microenvironment, modulate cardiac homeostasis through their vascular differentiation potential and paracrine activity. Transcriptomic analysis of cMSCs identified age‐dependent biological pathways regulating immune responses and angiogenesis. Aged cMSCs displayed a senescence program characterized by Cdkn2a expression, decreased proliferation and clonogenicity, and acquisition of a senescence‐associated secretory phenotype (SASP). Increased CCR2‐dependent monocyte recruitment by aged cMSCs was associated with increased IL‐1ß production by inflammatory macrophages in the aging heart. In turn, IL‐1ß induced senescence in cMSCs and mimicked age‐related phenotypic changes such as decreased CD90 expression. The CD90+ and CD90‐ cMSC subsets had biased vascular differentiation potentials, and CD90+ cMSCs were more prone to acquire markers of the endothelial lineage with aging. These features were related to the emergence of a new cMSC subset in the aging heart, expressing CD31 and endothelial genes. These results demonstrate that cMSC senescence and SASP production are supported by the installation of an inflammatory amplification loop, which could sustain cMSC senescence and interfere with their vascular differentiation potentials.
Increased mortality from somatic multimorbidity in patients with schizophrenia: a Danish nationwide cohort study
Authors: Kugathasan P. , Stubbs B. , Aagaard J. , Jensen S. E. , Munk Laursen T. , Nielsen R. E. 
Published: July 2019

ObjectiveTo investigate the association of single‐ and multimorbidity with mortality rates in patients with schizophrenia compared to the general population.MethodA nationwide cohort study including residents in Denmark between 1995 and 2015. The cohort was dichotomously divided by a diagnosis of schizophrenia. Somatic diseases included infections, cancer, endocrine, neurologic, cardiovascular, respiratory, digestive, skin, musculoskeletal, and urogenital diseases. Hazard ratios (HRs) and population attributable fractions (PAFs) were calculated.ResultsThe cohort included 30 210 patients with schizophrenia [mean age (SD) = 32.6 (11.4), males = 57.2%], and 5 402 611 from the general population [mean age (SD) = 33.0 (14.5), males = 50.4%]. All number of somatic diseases were associated with an increased mortality in schizophrenia [HR = 16.3 (95% CI = 15.4–17.3) for 1 disease to 21.0 (95% CI = 19.1–23.0) for ≥5 diseases], using the general population with no somatic disease as reference. Across all somatic diseases, patients with schizophrenia showed a HR > 2, compared to the general population, and respiratory (PAF = 9.3%), digestive (PAF = 8.2%), and cardiovascular (PAF = 7.9%) diseases showed largest contributions to death.ConclusionsPatients with schizophrenia showed higher mortality on all levels of multimorbidity, and a doubled mortality rate across all somatic diseases, compared to the general population. The findings suggest that the clusters and trajectories of symptoms associated with schizophrenia is the main driver of the excess mortality.
Occurrence of complete heart block associated with acute renal infarction
Authors: Su Yi‐Ching , Hsu Chun‐Hsien 
Published: July 2019

AbstractComplete heart block (CHB) and acute renal infarction (ARI) are both uncommon diseases and seldom encountered in the clinical practice. We describe a rare case of pre‐existing left bundle branch block, presenting simultaneously with CHB and ARI. The possible mechanism depends on prior presence of either CHB or ARI. If ARI occurs first, severe pain and embolism may enhance the vagal tone resulting in decrease in the heart rate and transient intraventricular conduction interruption, which subsequently causes CHB. The opposite scenario, CHB preceding ARI, is also possible. CHB can be physiologic and transient, with higher risk of development in the circumstance of pre‐existing conduction system disturbances. Patients with CHB are predisposed to formation of thrombi and thromboemboli, giving rise to ARI. In conclusion, awareness and timely identification of the clinical manifestations of these two diseases may facilitate early diagnosis and prompt management.
No interactions between heparin and atacicept, an antagonist of B cell survival cytokines
Authors: Kowalczyk‐Quintas Christine , Willen Daniela , Willen Laure , Golob Michaela , Schuepbach‐Mallepell Sonia , Peter Benjamin , Eslami Mahya , Vigolo Michele , Broly Hervé , Samy Eileen , Yalkinoglu Özkan , Schneider Pascal 
Published: July 2019

Background and PurposeThe TNF family ligands, B cell activating factor of the TNF family (BAFF, also known as B lymphocyte stimulator, BLyS) and a proliferation‐inducing ligand (APRIL), share the transmembrane activator and calcium‐modulator and cyclophilin ligand (CAML)‐interactor (TACI) as one of their common receptors. Atacicept, a chimeric recombinant TACI/IgG1‐Fc fusion protein, inhibits both ligands. TACI and APRIL also bind to proteoglycans and to heparin that is structurally related to proteoglycans. It is unknown whether the portion of TACI contained in atacicept can bind directly to proteoglycans, or indirectly via APRIL, and whether this could interfere with the anti‐coagulant properties of heparin.Experimental ApproachBinding of atacicept and APRIL to proteoglycan‐positive cells was measured by FACS. Activities of heparin and atacicept were measured with activated factor Xa inhibition and cell‐based assays. Effects of heparin on circulating atacicept was monitored in mice.Key ResultsAtacicept did not bind to proteoglycan‐positive cells, but when complexed to APRIL could do so indirectly via APRIL. Multimers of atacicept obtained after exposure to cysteine or BAFF 60‐mer bound directly to proteoglycans. Atacicept alone, or in complex with APRIL, or in a multimeric form did not interfere with heparin activity in vitro. Conversely, heparin did not influence inhibition of BAFF and APRIL by atacicept and did not change circulating levels of atacicept.Conclusions and ImplicationsLack of detectable interference of APRIL‐bound or free atacicept on heparin activity makes it unlikely that atacicept at therapeutic doses will interfere with the function of heparin in vivo.
Sandwich osteotomy in atrophic mandibles: A retrospective study with a 2‐ to 144‐month follow‐up
Authors: Geng Yuan‐ming , Zhou Miao , Parvini Patricia , Scarlat Sebastian , Naujokat Hendrik , Abraha Sophia Mulugeta , Terheyden Hendrik 
Published: July 2019

AbstractObjectivesThe aim of the present retrospective study was to assess the long‐term clinical outcome of sandwich osteotomy in pre‐implant augmentation of atrophic mandible.Materials and methodsSandwich osteotomies were performed in partially and fully edentulous mandibles of 63 consecutive patients in the present study. The vertical bone gain, graft stability, and marginal bone loss were measured radiographically. Implant survival and success rates were estimated in the follow‐up ranged from 2 to 144 months (mean, 58 months).ResultsA total of 75 procedures were reviewed. After an average healing time of 148 days, 220 implants were placed in 74 procedures. Perioperative complications included intraoperative fracture (1/75), transient paresthesia (18/75), wound healing disturbance (18/75), and keratinized tissue deficiency (14/75). The average vertical bone gain was 5.4 mm at the time of implant placement. Significant marginal bone loss occurred during the first 6 months, after which the resorption remained stable. The implant survival rate was estimated as 96.7%, and the success rate was 95.3%. Implant survival and success showed no significant correlation with higher age, anticoagulation therapy, cardiovascular disease, or thyroid disorder. Smoking was correlated with significant lower success rate.ConclusionSandwich osteotomy is a suitable augmentation procedure for atrophic mandible, allowing for implant placement with promising outcome.
Performatively Driven: A Genre for Signifying in Popular Music Exhibitions
Authors: Cortez Alcina 
Published: July 2019

AbstractThis article explores a relatively novel field of practice, or genre, emerging in the context of museums and exhibitions of popular music and what I will refer to as performatively driven, here discussed and illustrated with examples drawn from particular international exhibitions that I have visited. This genre is comprised of a myriad of strategies used by curators to give substance to their exhibiting narratives that tends to cluster into four essential types – (i) exhibiting sound and music; (ii) dramatic strategies (for current purposes, the example of contrast is considered); (iii) enveloping strategies, and (iv) sound epistemologies – and all of which draw on combinations of multifarious exhibits (material and immaterial). In terms of their signifying potential, my analysis points to these strategies, each of them focused on imparting meaning in an experiential rather than a purely rational sense, as achieving the following ends: conveying notions of popular music as object and artifact; eliciting emotional responses and prompting engagement; valuing museumgoers’ individualities, while also locating them as part of a community (e.g., of music fans, of followers of a particular musical artist, of a particular generation); providing re‐enactment (both by reconstructing scenarios from the past or from live concerts and by activating memories offered of popular music); and conveying knowledge. As these signifying strategies dissolve into the aforementioned meanings in an experiential rather than in a more rational sense, I would suggest they are correspondingly rooted in the concept of performance and therefore propose adding this concept to the typology of concepts presented by Baker et al. (2018).
Integrating resistance functions to predict response to induction chemotherapy in de novo acute myeloid leukemia
Authors: Chiu Yu‐Chiao , Hsiao Tzu‐Hung , Tsai Jia‐Rong , Wang Li‐Ju , Ho Tzu‐Chieh , Hsu Shih‐Lan , Teng Chieh‐Lin Jerry 
Published: July 2019

AbstractObjectivesThis study explored resistance functions and their interactions in de novo AML treated with the “7 + 3” induction regimen.MethodsWe analyzed RNA‐sequencing profiles of whole bone marrow samples from 52 de novo AML patients who completed the “7 + 3” regimen and stratified patients into CR (n = 35) and non‐CR (n = 17) groups.ResultsA systematic gene set analysis revealed significant associations between chemoresistance and mTOR (P < .001), myc (P < .001), mitochondrial oxidative phosphorylation (P < .001), and stemness (P = .002). These functions were independent with regard to gene contents and activity scores. An integration of these four functions showed a prediction of chemoresistance (area under the receiver operating characteristic curve = 0.815) superior to that of each function alone. Moreover, our proposed seven‐gene scoring system significantly correlated with the four‐function model (r = .97; P < .001) to predict chemoresistance to the “7 + 3” regimen. On multivariate analysis, a seven‐gene score of ≥−0.027 (hazard ratio: 11.18; 95% confidence interval: 2.06‐60.65; P = .005) was an independent risk factor for induction failure.ConclusionsMyc, OXPHOS, mTOR, and stemness were responsive for chemoresistance in AML. Treatments other than the “7 + 3” regimen need to be considered for de novo AML patients predicted to be refractory to the “7 + 3” regimen.
Twenty years of research on total quality management in Higher Education: A systematic literature review
Authors: Nasim Kanwal , Sikander Arif , Tian Xiaowen 
Published: July 2019

AbstractFaced with intensified global education competition, universities and other Higher Education institutions are implementing Total Quality Management (TQM) to keep rivals at bay. Meanwhile, research interest in TQM in Higher Education is growing. This paper reviews the achievements and limitations of extant research on TQM in Higher Education, and discusses directions for future research. The paper finds that extant research focuses on (1) teaching and learning but neglects research and industry engagement; (2) an isolated factor (e.g., teacher) but neglects other factors (e.g., facilities); (3) the Higher Education sector in advanced countries but neglects the Higher Education sector in developing countries; and (4) TQM as a phenomenon but neglects theory development and integration. Future research needs to address these limitations, adopt a more holistic perspective, and take a more inclusive and comprehensive approach to TQM in the Higher Education sector.
Cellular therapy: Immune‐related complications
Authors: Oved Joseph H. , Barrett David M. , Teachey David T. 
Published: July 2019

AbstractThe advent of chimeric antigen receptor T (CAR‐T) and the burgeoning field of cellular therapy has revolutionized the treatment of relapsed/refractory leukemia and lymphoma. This personalized “living therapy” is highly effective against a number of malignancies, but this efficacy is tempered by side effects relatively unique to immunotherapies, including CAR‐T. The overwhelming release of cytokines and chemokines by activated CAR‐T and other secondarily activated immune effector cells can lead to cytokine release syndrome (CRS), which can have clinical and pathophysiology similarities to systemic inflammatory response syndrome and macrophage activating syndrome/hemophagocytic lymphohistiocytosis. Tocilizumab, an anti‐IL6 receptor antibody, was recently FDA approved for treatment of CRS after CAR‐T based on its ability to mitigate CRS in many patients. Unfortunately, some patients are refractory and additional therapies are needed. Patients treated with CAR‐T can also develop neurotoxicity and, as the biology is poorly understood, current therapeutic interventions are limited to supportive care. Nevertheless, a number of recent studies have shed new light on the pathophysiology of CAR‐T‐related neurotoxicity, which will hopefully lead to effective treatments. In this review we discuss some of the mechanistic contributions intrinsic to the CAR‐T construct, the tumor being treated, and the individual patient that impact the development and severity of CRS and neurotoxicity. As CAR‐T and cellular therapy have redefined the concept of personalized medicine, so too will personalization be necessary in managing the unique side effects of these therapies.