bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of computerized maintenance management system and relevant supportive organizational factors on total productive maintenance
Authors: Balouei Jamkhaneh Hadi , Khazaei Pool Javad , Khaksar Seyed Mohammad Sadegh , Arabzad S. Mohammad , Verij Kazemi Reza 
Published: August 2018

Purpose
The application of automated systems is rapidly increasing in different industries and organizations. In this regard, computerized maintenance management systems (CMMS) using information technology play an important role in the automating production systems. The purpose of this paper is to investigate the impacts of CMMSs and relevant supportive organizational factors on the effectiveness of total productive maintenance.

Design/methodology/approach
This study is classified as a quantitative survey-based research using structural equation modeling. The scope of the study includes manufacturing companies in Iran. A total of 125 questionnaires from 60 companies were collected from January to March 2014 to help validate the conceptual model and test the hypotheses.

Findings
The results support the concept CMMSs positively relates to relevant supportive organizational factors (resource allocation, decision-making structure, senior management support, employees’ involvement and effective instruction) on the effectiveness of total productive maintenance. The relevant supportive organizational factors can also be seen as the predictors of CMMSs.

Originality/value
This study integrates the CMMSs and relevant supportive organizational factors in a robust model to examine the effectiveness of total productive maintenance. This study also examines the impacts of CMMSs and relevant supportive organizational factors on total productive maintenance which seems to not be done previously.
International new ventures and firm performance: evidence from India
Authors: Fuad Mohammad , Akbar Mohammad 
Published: August 2018

PurposeThis study aims to explore the role of liberalization, business group affiliation and degree of internationalization (DOI) on the performance of Indian international new ventures (INVs).Design/methodology/approachThe study identifies Indian INVs incorporated between 1991 and 2010 against the backdrop of liberalization. To test various hypotheses, a random effects panel regression analysis was conducted for publicly listed Indian INVs.FindingsThe results highlight that business group affiliation and DOI are positively related to INV performance. Further, liberalization negatively moderates the relationship between group affiliation and INV performance. The authors’ findings indicate that as institutions improve, the positive effect of business group affiliation on firm performance decreases in emerging markets.Research limitations/implicationsThis paper highlights the benefits accruing to business group affiliated INVs and the moderating role of liberalization on firm performance. Future studies may augment the authors’ understanding of INV performance by testing heterogeneity within business groups and their impact on INV performance across other emerging economies.Practical implicationsAs institutional reforms strengthen over time, the positive effect of group affiliation on INV performance declines. Hence, managers of group affiliates need to adapt to the changing institutions faster and develop their fit with the institutional environment earlier than standalone firms, to mitigate their profitability issues.Originality/valueTo the best of the authors’ knowledge, this is the first paper to discuss the role of business group affiliation and the moderating role of liberalization on INV performance with theoretical and managerial implications.
Low-cost retrofit packages for residential buildings in hot-humid Lagos, Nigeria
Authors: Onyenokporo Nwakaego Chikaodinaka , Ochedi Ekele Thompson 
Published: August 2018

Purpose
The purpose of this paper is to develop a set of affordable retrofit packages that can be applied to existing residential buildings in hot-humid regions to improve occupants’ thermal comfort and reduce energy consumption.

Design/methodology/approach
A critical review of relevant literature to identify passive design strategies for improving thermal comfort and reducing energy consumption in hot-humid climates with focus on the building envelope was conducted in addition to a simulation study of an existing building typology in study area.

Findings
There is enormous potential to reduce energy costs and improve thermal comfort through building retrofit packages which is a recent concept in developing countries, such as Nigeria. Analysing the results of the retrofit interventions using building energy simulation helped in developing affordable retrofit packages which had optimum effect in improving indoor comfort temperature to the neutral temperature specified for hot humid Nigeria and further down to 3°C less than that of the reference building used. The use of passive design strategies to retrofit the building might help homeowners reduce their annual energy consumption by up to 46.3 per cent just by improving the indoor thermal comfort.

Originality/value
In addition to improving thermal comfort and reducing energy consumption, this research identified affordable retrofit packages and considered its cost implications especially to low-income earners who form a larger population of Lagos, Nigeria, as this was not considered by many previous researchers.
Diversity: a matter of reality or perception?
Authors: Jaiswal Akanksha , Dyaram Lata 
Published: August 2018

PurposeWhile extant literature is replete with studies on actual diversity, research on perceived diversity is scant. The authors examine perceived diversity as an underlying mechanism explaining the effect of actual diversity on affect-related outcome (employee well-being).Design/methodology/approachIn total, 617 full-time employees from large organizations representing varied industries in India have participated in the survey-based study. The authors used PROCESS macro for mediation analysis.FindingsAn index estimating actual surface-level diversity was found to correlate significantly with perceived surface-level diversity. Perceived diversity was found to significantly impact employee well-being, thereby, demonstrating its mediating role in the link between actual diversity and well-being.Research limitations/implicationsBeyond the underlying processes of diversity, effects such as diversity perceptions, contextual factors conditioning diversity effects need exploration.Practical implicationsInvestigation of both actual and perceived diversity improves the explanation of diversity effects. Besides compositional mix, managers must tap on employee perceived differences to understand and leverage diversity and its effects.Originality/valueBesides contributing to the emerging interest in empirical examination of perceived diversity on employee outcomes, this study develops an index to estimate actual surface-level diversity.
Individual disposition and manager behaviour on employee upward voice
Authors: Edakkat Subhakaran Sriji , Dyaram Lata 
Published: August 2018

PurposeThis paper aims to model how an employee’s proactive personality and manager’s pro-voice behaviour help to predict employee upward voice. Employee perceived voice efficacy is expected to mediate these links.Design/methodology/approachTo analyse the data, a confirmatory factor analysis and structural equation modelling procedure using AMOS 22 were used. The mediating role of voice efficacy was tested with bootstrapping method. Data included 625 employees representing various technology firms in India.FindingsThe results showed a significant positive impact of employee proactive personality and manager pro-voice behaviour on employee upward voice. Further, findings suggest significant mediation of employee voice efficacy beliefs in these links.Originality/valueThe study extends employee voice literature from an Indian context, where confronting those in authority is culturally discouraged. Contributing to the scant work on voice self-efficacy, its role as a key mechanism impacting employee upward voice is examined.
The SEC’s final rule regarding price quotes and research reports relating to security-based swaps
Authors: Schwartz James 
Published: August 2018

Purpose
This paper aims to summarize the requirements of a new US Securities and Exchange Commission (SEC) rule regarding certain communications relating to security-based swaps in the context of the SEC’s ongoing efforts to establish its regulatory regime for such swaps.

Design/methodology/approach
This paper provides a close analysis of an SEC final rule that provides that certain communications relating to security-based swaps will not constitute “offers” for purposes of Section 5 of the Securities Act of 1933, under which generally offers or sales of a security must be registered or made pursuant to an exemption from registration. The paper also analyzes the prospects for a general exemption from registration requirements for security-based swaps involving eligible contract participants, and it places the final rule in the context of the SEC’s broader efforts to establish its final rules for security-based swaps.

Findings
In addition to detailing the requirements of the final rule, this paper concludes that it is unlikely that the SEC will decide, generally, to exempt many security-based swaps from registration requirements, and that it is likely that a significant amount of time will elapse before the SEC finalizes most of its remaining rules for security-based swaps.

Originality/value
This paper contains valuable information regarding the regulation of security-based swaps in the context of securities regulation and the SEC’s other rules for such swaps.
Differential Impact of Hospital and Community Factors on Medicare Readmission Penalties
Authors: Aswani Monica S. , Kilgore Meredith L. , Becker David J. , Redden David T. , Sen Bisakha , Blackburn Justin 
Published: August 2018

ObjectiveTo identify hospital/county characteristics and sources of regional heterogeneity associated with readmission penalties.Data Sources/Study SettingAcute care hospitals under the Hospital Readmissions Reduction Program from fiscal years 2013 to 2018 were linked to data from the Annual Hospital Association, Centers for Medicare and Medicaid Services, Medicare claims, Hospital Compare, Nursing Home Compare, Area Resource File, Health Inequity Project, and Long‐term Care Focus. The final sample contained 3,156 hospitals in 1,504 counties.Data Collection/Extraction MethodsData sources were combined using Medicare hospital identifiers or Federal Information Processing Standard codes.Study DesignA two‐level hierarchical model with correlated random effects, also known as the Mundlak correction, was employed with hospitals nested within counties.Principal FindingsOver a third of the variation in readmission penalties was attributed to the county level. Patient sociodemographics and the surrounding access to and quality of care were significantly associated with penalties. Hospital measures of Medicare volume, percentage dual‐eligible and Black patients, and patient experience were correlated with unobserved area‐level factors that also impact penalties.ConclusionsAs the readmission risk adjustment does not include any community‐level characteristics or geographic controls, the resulting endogeneity bias has the potential to disparately penalize certain hospitals.
Efficacy and safety of rh‐endostatin (Endostar) combined with pemetrexed/cisplatin followed by rh‐endostatin plus pemetrexed maintenance in non‐small cell lung cancer: A retrospective comparison with standard chemotherapy
Authors: Zhou Shengyu , Zuo Lijie , He Xiaohui , Pi Jinping , Jin Jun , Shi Yuankai 
Published: August 2018

BackgroundRecombinant human endostatin (rh‐endostatin) plus standard chemotherapy in advanced non‐small cell lung cancer (NSCLC) patients has shown improved efficacy; however, it is unclear whether it is effective and safe when added to pemetrexed/cisplatin and used as maintenance therapy.MethodsWe retrospectively evaluated the data of untreated NSCLC patients administered rh‐endostatin plus pemetrexed/cisplatin or pemetrexed/cisplatin. The primary endpoint was progression‐free survival (PFS).ResultsFifty‐six and 39 patients received rh‐endostatin plus pemetrexed/cisplatin and pemetrexed/cisplatin, and 34 and 29 underwent maintenance treatment, respectively. The median PFS was 10 months (95% confidence interval [CI] 5.85–14.15) in the rh‐endostatin and 8.2 months (4.04–12.36) in the chemotherapy group, but the difference was not statistically significant (P = 0.13). In patients administered maintenance treatment, rh‐endostatin plus pemetrexed was associated with prolonged PFS compared to single‐agent pemetrexed when PFS was calculated from first dosing (13.7 [9.41–17.99] vs. 8.2 [4.16–12.24]; P = 0.032); however, PFS did not differ between the groups (hazard ratio 0.618; 95% CI 0.368–1.038; P = 0.069) after adjusting for clinical factors. No difference was observed in the objective response rate between the groups (48.2% vs. 38.5%; P = 0.346), with the exception of men (62.1% vs. 33.3%; P = 0.032) or in the incidence of drug‐related or grade 3–4 adverse events.ConclusionIn previously untreated, advanced‐stage NSCLC patients, first‐line treatment with pemetrexed/cisplatin plus rh‐endostatin did not prolong PFS or overall survival when compared to pemetrexed/cisplatin, but a trend of improved PFS was observed in patients administered maintenance rh‐endostatin plus pemetrexed.
Comparative effectiveness of concurrent chemoradiotherapy versus EGFR‐tyrosine kinase inhibitors for the treatment of clinical stage IIIb lung adenocarcinoma patients with mutant EGFR
Authors: Hsia Te‐Chun , Liang Ji‐An , Li Chia‐Chin , Chien Chun‐Ru 
Published: August 2018

BackgroundThe standard of care for fit locally advanced non‐small cell lung cancer (NSCLC) patients is concurrent chemoradiotherapy (CCRT). However, in a subset of patients with lung adenocarcinoma with mutant EGFR (LA‐mEGFR), the role of EGFR‐tyrosine kinase inhibitors (TKIs) is not clear. We compared CCRT versus TKIs for the treatment of stage IIIb LA‐mEGFR in a Taiwanese population.MethodsWe identified patients from the Taiwan Cancer Registry with good performance status at clinical stage IIIb LA‐mEGFR, diagnosed from June 2011 to December 2015 and treated with either TKIs or CCRT. Clinical covariables and survival status were also collected. The Cox regression method was used in the primary analyses and several propensity score methods and alternative study cohort definitions were used in additional analyses.ResultsWe compared the data of 177 TKI and 22 CCRT patients and found no statistically significant difference in overall (adjusted hazard ratio of death 0.71, 95% confidence interval 0.34–1.47) or lung cancer‐specific survival (hazard ratio 0.65, 95% confidence interval 0.31–1.35). The results of most additional analyses were insignificant.ConclusionIn this population‐based study from Taiwan with limited case numbers, no statistical difference in the survival outcomes of patients with clinical stage IIIb LA‐mEGFR treated with either EGFR‐TKIs or CCRT was determined. Further prospective studies are needed to clarify our findings.
Effects of artificial illumination on drinking bats: a field test in forest and desert habitats
Authors: Russo D. , Ancillotto L. , Cistrone L. , Libralato N. , Domer A. , Cohen S. , Korine C. 
Published: August 2018

AbstractBats show pronounced and often‐adverse reactions to artificial illumination at night (ALAN) when commuting, roosting or foraging. ALAN also affects bat drinking activity, at least when lighting occurs over short intervals. We tested whether continuous illumination of drinking sites over 4‐h periods would lead bats to tolerate ALAN and resume drinking in the course of the night. We conducted our experiments in forest (Italy) and desert (Israel) sites to test whether in the latter habitat, where water is scarce, a greater motivation to drink might lead to less adverse bat reactions. We recorded 6853 drinking buzzes and 1647 feeding buzzes from 17 species and one species group. In the forest sites, species that hunt in open spaces or along forest edges showed little (P. pipistrellus and H. savii) or no (P. kuhlii and N. leisleri) drinking activity decrease, while those associated with forest interiors (Barbastella barbastellus, Plecotus auritus and bats in the genus Myotis) exhibited a strong negative response. In the desert sites, all studied species reduced drinking activity, yet in the desert populations of P. kuhlii we recorded stronger adverse reactions only far from human settlements. The harsh reactions that the desert bat species showed towards ALAN rule out any effect of a greater motivation to drink. Illumination had no effect on foraging by most species, except in the forest sites, where Pipistrellus kuhlii and Nyctalus leisleri increased foraging when the light was on, and in the desert sites, where Hypsugo bodenheimeri decreased foraging in such situations. The progressive human encroachment that is taking place in many world regions on both forests and especially deserts, where few sites for drinking are available, may jeopardize bat populations also through increased exposure to ALAN.
Validation of the Emotion Regulation Questionnaire in older community‐dwelling adults
Authors: Brady Brooke , Kneebone Ian I. , Bailey Phoebe E. 
Published: August 2018

ObjectiveTo examine the psychometric properties of the Emotion Regulation Questionnaire (ERQ) among a sample of older community‐dwelling males and females and to also assess gender differences in the association between emotion regulation and positive and negative affect.MethodThe ERQ and the Positive and Negative Affect Schedule‐10 were administered to 252 older adults (age range 60–89 years; 48.4% female).ResultsThe two ERQ subscales, reappraisal and suppression, were internally consistent. Reappraisal was positively correlated with positive affect among both genders, and negatively correlated with negative affect among older women only. Suppression was positively correlated with negative affect among older men only and unrelated to positive affect for both genders. Confirmatory factor analysis showed that a two‐factor solution fits the data from both genders.ConclusionThe results provide evidence to support the ERQ for use with older adults, while identifying clinically important gender differences in the associations between emotion regulation tendencies and affect in older age.Practitioner points

Reliability and validity of the 10‐item Emotion Regulation Questionnaire is supported for use among older adults.

Suppression positively correlated with negative affect among older men but not older women.

Reappraisal negatively correlated with negative affect among older women but not men.

The current data from a community‐dwelling population may not generalize to older adults with clinical disorders.
Bevacizumab‐enhanced antitumor effect of 5‐fluorouracil via upregulation of thymidine phosphorylase through vascular endothelial growth factor A/vascular endothelial growth factor receptor 2‐specificity protein 1 pathway
Authors: Liu Wenyue , Zhang Jingwei , Yao Xuequan , Jiang Chao , Ni Ping , Cheng Lingge , Liu Jiali , Ni Suiying , Chen Qianying , Li Qingran , Zhou Kai , Wang Guangji , Zhou Fang 
Published: August 2018

Bevacizumab (Bv) can be used synergistically with fluoropyrimidine‐based chemotherapy to treat colorectal cancer. Whether and how it affects the delivery of fluoropyrimidine drugs is unknown. The present study aimed to explore the effect of Bv on the delivery of 5‐fluorouracil (5‐FU) to tumors and the underlying mechanism from metabolic perspective. Bv enhanced the anti‐tumor effects of 5‐FU in LoVo colon cancer xenograft mice and increased the 5‐FU concentration in tumors without affecting hepatic 5‐FU metabolism. Interestingly, Bv remarkably upregulated thymidine phosphorylase (TP) in tumors, which mediated the metabolic activation of 5‐FU. Although TP is reported to promote angiogenesis and resistance, the combination of Bv and 5‐FU resulted in anti‐angiogenesis and vessel normalization in tumors, indicating that the elevated TP mainly contributed to the enhanced response to 5‐FU. Bv also induced TP upregulation in LoVo cancer cells. Treatment with vascular endothelial growth factor receptor 2 (VEGFR2) antagonist apatinib and VEGFR2 silencing further confirmed TP upregulation. Bv and apatinib both enhanced the cytotoxicity of 5‐FU in LoVo cells, but there was no synergism with adriamycin and paclitaxel. We further demonstrated that the effect of Bv was dependent on VEGFR2 blockade and specificity protein 1 activation via MDM2 inhibition. In summary, Bv enhanced the accumulation of 5‐FU in tumors and the cytotoxicity of 5‐FU via TP upregulation. We provide data to better understand how Bv synergizes with 5‐FU from metabolic perspective, and it may give clues to the superiority of Bv in combination with fluoropyrimidine drugs compared to other chemotherapeutic drugs in colon cancer.
Inhibin B suppresses anoikis resistance and migration through the transforming growth factor‐β signaling pathway in nasopharyngeal carcinoma
Authors: Zou Guoying , Ren Biqiong , Liu Yi , Fu Yin , Chen Pan , Li Xiayu , Luo Shudi , He Junyu , Gao Ge , Zeng Zhaoyang , Xiong Wei , Li Guiyuan , Huang Yumei , Xu Keqian , Zhang Wenling 
Published: August 2018

Inhibin B (INHBB), a heterodimer of a common α‐subunit and a βB‐subunit, is a glycoprotein belonging to the transforming growth factor‐β (TGF‐β) family. In this study, we observed INHBB expression was reduced in nasopharyngeal carcinoma (NPC) tissues compared to non‐tumor nasopharyngeal epithelium tissues, and INHBB was associated with lymph node metastasis, stage of disease, and clinical progress. Positive expression of INHBB in NPC predicted a better prognosis (overall survival, P = 0.038). However, the molecular mechanisms of INHBB have not been addressed in NPC. We induced anoikis‐resistant cells in NPC cell lines under anchorage‐independent conditions, then found epithelial‐mesenchymal transition markers changed, cell apoptosis decreased, cell cycle was modified, and invasion strengthened in anoikis‐resistant NPC cells. These anoikis‐resistant NPC cells showed decreased expression of INHBB compared with adhesion cells. Furthermore, INHBB was found to influence the above‐mentioned changes. In the anoikis‐resistant NPC cells with INHBB overexpression, apoptotic cells increased, S phase cells weakened, vimentin, matrix metallopeptidase‐9, and vascular endothelial growth factor A expression were downregulated, and E‐cadherin expression was upregulated, and vice versa in knockdown of INHBB (INHBB shRNA) anoikis‐resistant NPC cells. Diminished INHBB expression could activate the TGF‐β pathway to phosphorylate Smad2/3 and form complexes in the nucleus, which resulted in the above changes. Thus, our results revealed for the first time that INHBB could suppress anoikis resistance and migration of NPC cells by the TGF‐β signaling pathway, decrease p53 overexpression, and could serve as a potential biomarker for NPC metastasis and prognosis as well as a therapeutic application.