bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repeated games for eco-friendly flushing in reservoirs
Authors: Khakzad Hamid 
Published: May 2019

Abstract
Repeated games, an important mathematical formalism, open attractive perspectives in the modeling and studying of interactions between multiple self-interested parties (individuals or groups). The main conceptual difference between static, and repeated and dynamic games is that the former have a preset, finite number of turns, while the latter can potentially last forever and end only with a decision by a player, or by chance. Unlike previous surveys of repeated games, which originated mainly from the economics research community, the performances of repeated games were investigated in this study for evaluating the time required to flush a reservoir, taking account of water quantity and quality. A sediment-flushing model was developed to estimate the flushed sediment and water volumes, and operating period of flushing, to be taken into account in the reservoir simulation model. Dez Hydropower Reservoir in Iran was chosen as the case study for applying the proposed methodology. The results show that the methodology provides an effective and useful tool for reservoir operation.
Recognition of Lung Adenocarcinoma-specific Gene Pairs Based on Genetic Algorithm and Establishment of a Deep Learning Prediction Model
Authors: Zhao Zhongwei , Fan Xiaoxi , Yang Lili , Song Jingjing , Fang Shiji , Tu Jianfei , Chen Minjiang , Li Jie , Zheng Liyun , Wu Fazong , Zhang Dengke , Ying Xihui , Ji Jiansong 
Published: May 2019

Aim and Objective:Lung cancer is a disease with a dismal prognosis and is the major cause of cancer deaths in many countries. Nonetheless, rapid technological developments in genome science guarantees more effective prevention and treatment strategies.Materials and Methods:In this study, genes were pair-matched and screened for lung adenocarcinomaspecific gene relationships. False positives due to fluctuations in single gene expression were avoided and the stability and accuracy of the results was improved.Results:Finally, a deep learning model was constructed with machine learning algorithm to realize the clinical diagnosis of lung adenocarcinoma in patients.Conclusion:Comparing with the traditional methods which takes ingle gene as a feature, the relative difference between gene pairs is a higher order feature, leverage high-order features to build the model can avoid instability caused by a single gene mutation, making the prediction results more reliable.
Molecular Characterization of HIV-1 Minority Subtypes in Hong Kong: A Recent Epidemic of CRF07_BC among the Men who have Sex with Men Population
Authors: Leung Kenneth Siu-Sing , To Sabrina Wai-Chi , Chen Jonathan Hon-Kwan , Siu Gilman Kit-Hang , Chan Kenny Chi-Wai , Yam Wing-Cheong 
Published: May 2019

Background:
Over the past years, an increasing trend was noticed for non-B and non-
CRF01_AE HIV-1 strains prevalence in Hong Kong.

Objective:
In this study, we aimed at using the available HIV-1 pol sequences collected from 1994
to 2013 through our local antiretroviral resistance surveillance program to investigate the molecular
epidemiology and evolution of HIV-1 minority subtypes in Hong Kong. We also aimed at investigating
their potential association and impact of those transmission risk groups.

Methods:
A total of 2,315 HIV-1 partial pol sequences were included. HIV-1 genotypes were determined
by REGA Genotyping Tool and phylogenetic analysis with reference sequences. The viral
evolutionary rates and time of the most common ancestor (tMRCA) were estimated by Bayesian
Markov Chain Monte Carlo (MCMC) interference.

Results:
Apart from the two prevalent HIV-1 genotypes in Hong Kong (subtype B,41.6%,
CRF01_AE,40.5%), phylogenetic analysis revealed a broad viral diversity including
CRF07_BC(5.1%), subtype C(4.5%), CRF02_AG(1.1%), CRF08_BC(0.8%), subtype A1(0.8%),
subtype G(0.4%), subtype D(0.4%), CRF06_cpx(0.4%), subtype F(0.1%), CRF12_BF(0·04%) and
other recombinants(4.5%). The top five minority subtypes were further analyzed which demonstrated
distinct epidemiological and phylogenetic patterns. Over 70% of subtypes A1, C and
CRF02_AG infections were circulated among non-Chinese Asians or African community in Hong
Kong and were mainly transmitted between heterosexual regular partners. Instead, over 90% of
CRF07_BC and CRF08_BC patients were Chinese. An epidemic cluster was identified in
CRF07_BC and estimated to expand from 2002 onwards based on skyline plot and molecular clock
analysis.

Conclusion:
Our results highlighted the emergence of CRF07_BC epidemic in local MSM community,
public health interventions targeting the community should be further enhanced to tackle the
epidemic.
The Potential Use of Grape Phytochemicals for Preventing the Development of Intestine-Related and Subsequent Inflammatory Diseases
Authors: Santa Kazuki , Kumazawa Yoshio , Nagaoka Isao 
Published: May 2019

Background:
Grape phytochemicals prevent intestine-related and subsequent other inflammatory
diseases. Phytochemicals and vitamin D are useful for the regulation of inflammatory responses.
Phytochemicals is the generic name for terpenoids, carotenoids, and flavonoids that consist of
a variety of chemicals contained in vegetables and fruits. There are a variety of grape cultivars that
contain many kinds of phytochemicals in their skin and seeds. Grape phytochemicals including Grape
Seed Extracts (GSE) have already been used to maintain healthy condition through manipulating inflammatory
responses by decreasing the expression of inflammation-related factors.

Discussion:
Grape phytochemicals mainly consist of a variety of chemicals that include terpenoid
(oleanolic acid), carotenoids (β-carotene, lutein), and flavonoids: flavon-3-ols (quercetin), flavan-3-ols
(catechins), anthocyanins, oligomers and polymers (tannins and proanthocyanidins), and resveratrol.
Phytochemicals improve the dysbiosis (gut microbiota complication) induced by metabolic syndrome
and regulate inflammatory diseases induced by TNF-α production. Once absorbed, flavonoids change
into glucuronide-form, move into the bloodstream and reach the inflammatory sites including liver,
lung, and sites of arteriosclerosis, where they become active. Furthermore, oleanolic acid acts on TGR5
- the cholic acid receptor, as an agonist of cholic acid. These anti-inflammatory effects of phytochemicals
have been proven by the experimental animal studies and the clinical trials.

Conclusion:
It is expected the new health food products will be created from grape skins and seeds
since grape phytochemicals participate in the prevention of inflammatory diseases like intestine-related
inflammatory diseases.
A aprendizagem de línguas assistida por dispositivos móveis para ultrapassar as barreiras dos alunos relativamente ao treino de pronúncia
Authors: Nealy Marcellus 
Published: May 2019

This paper describes a qualitative investigation of learner’s perceptions of a mobile assisted language learning (MALL) tool for improving attitudes towards English pronunciation study. Our goal was to reduce the barriers to learning and improve learners’ experience. To do this, MALL was implemented via the development of an e-learning app called SOMONA. The curriculum design of the SOMONA program was based on Judy Gilbert’s Prosody Pyramid framework. The creative design was done intuitively through a series of brainstorming sessions. Simplicity, animation, bright colors and music were implemented as the key design features. Once the app passed usability testing, 20 learners were randomly selected to use the app and complete the English pronunciation course. Afterwards, they were given a survey to evaluate their attitudes towards the course material and the app as a learning tool. The objective was to determine if SOMONA was an effective way to overcome barriers to learning English pronunciation. The results showed an overwhelmingly positive response from the users and indicated that the application was indeed useful in overcoming learning barriers. More study needs to be done to determine if the app alone is effective in facilitating quantifiable improvement in English pronunciation.
Agenda de Eventos V.2, N.2 2016
Authors: Dobbins Chennyfer 
Published: May 2019

AAMC Leadership WeekLeadership Week is comprised of three custom developed, skill-building workshops precisely targeted to academic medicine faculty and staff. There will be ample opportunities to meet and network with other leaders in academic medicine, including a networking reception and organized dinners around the Washington, DC area. Date: January 31 to February 3 - 2017Local: Washington, DC – USAURL: http://www.cvent.com/events/2017-aamc-leadership-week/event-summary-c4ce099a381242af9b7c4a57389074da.aspx?RefID=aamcBRL
Prevenção da transmissão vertical da sífilis congênita: promoção da qualidade da assistência prestada à parturiente
Authors: Andrade Benedita Dos Santos , Abi Rached Chennyfer Dobbins 
Published: May 2019

A sífilis consiste em uma doença de caráter infeccioso, crônica e sistêmica, causada pela bactéria Treponema pallidum, subespécie pallidum, podendo apresentar períodos de agudização e latência, quando não detectada e tratada de forma precoce. Identificar as ações de prevenção para a sífilis congênita no contexto da assistência pré-natal. Foi realizada uma pesquisa bibliográfica com consulta nas bases de dados LILACS, SCIELO, com seleção de material publicado entre 2013 e 2018. O período pré-natal é essencial para a implementação ações de promoção à saúde e prevenção de complicações tanto para a mãe como para o bebê, através do desenvolvimento de ações educativas, que devem ser desenvolvidas todas as etapas do ciclo gravídico-puerperal visando contribuir com uma gestação sem complicações, e com o apoio físico e psicológico da gestante. Foi constatado com este estudo que a sífilis ainda representa um grave problema de saúde e que se não detectada precocemente, pode ser transmitida para bebê. E é nesse contexto que se ressalta a importância do pré-natal, para acompanhar as gestantes que visa estabelecer medidas de cuidados e controle de diversas doenças ou complicações, incluindo a sífilis, pois através desse acompanhamento já nas primeiras consultas, é preconizado o exame de rastreamento da doença, havendo, portanto, melhores chances de reduzir os riscos para o bebê, com uma identificação e tratamento precoce.
A Case Study Approach to Train Early-Stage Investigators in Transdisciplinary Research
Authors: Benesh, PhD Emily C. , Lamb, PhD Laura E. , Connors, PhD, MPH, CPH Shahnjayla K. , Farmer, PhD, MPH, MA Grant W. , Fuh, MD, PhD Katherine C. , Hunleth, PhD, MPH Jean , Montgomery, PhD, MSSW Katherine L. , Ramsey, PhD, MA Alex T. , Moley, MD Kelle H. , Colditz, MD, DrPH Graham A. , Gehlert, PhD Sarah J. 
Published: May 2019

Transdisciplinary (TD) research is a collaboration in which investigators from diverse backgrounds co-generate ideas. Few successful examples of TD research outcomes have been reported, possibly due to a training barrier. Here, TD trainees present a case study methodology that augmented classic training exercises by removing hierarchical barriers and allowing the practice of TD methodologies. A 30-minute development period was critical for the team to enter the conceptualization phase of TD research, making 90-minute sessions preferable for these exercises. Six sessions over an academic year were necessary for optimum idea formation. Generating buy-in was a challenge, as pressuring potential team members to participate would alter viewpoint equitability. Internal and external enthusiasm grew over the time period. Participation led to sustained collaborations and provided a marketable skillset. This method was low-cost and, likely, generalizable to other institutions. Thus, case study approaches may be effective tools to train researchers in TD interactions.
Predicting soft tissue changes after orthognathic surgery: The sparse partial least squares method
Authors: Suh Hee-Yeon , Lee Ho-Jin , Lee Yun-Sic , Eo Soo-Heang , Donatelli Richard E. , Lee Shin-Jae 
Published: May 2019

ABSTRACT

Objectives:
To develop a prediction algorithm for soft tissue changes after orthognathic surgery that would result in accurate predictions (1) regardless of types or complexity of operations and (2) with a minimum number of input variables.

Materials and Methods:
The subjects consisted of 318 patients who had undergone the surgical correction of Class II or Class III malocclusions. Two multivariate methods—the partial least squares (PLS) and the sparse partial least squares (SPLS) methods—were used to construct prediction equations. While the PLS prediction model included 232 input variables, the SPLS method included a reduced number of variables generated by a handicapping algorithm via the sparsity control. The accuracy between the PLS and SPLS models was compared.

Results:
There were no significant differences in prediction accuracy depending on surgical movements, the sex of the subjects, or additional surgeries. The predictive performance with a reduced set of 34 input variables chosen using the SPLS method was statistically indistinguishable from the full set of variables with the original PLS prediction model.

Conclusions:
The prediction method proposed in the present study was accurate for a wide range of orthognathic surgeries. A reduced set of input variables could be selected through the SPLS method while simultaneously maintaining a prediction level that was as accurate as that of the original PLS prediction model.
Influence of heat treatment on the structure and properties of polyamide 6/ halloysite nanocomposites
Authors: Mencel Kinga , Kemnitz Łukasz 
Published: May 2019

Abstract
The nanocomposites of polyamide 6 (PA6) with halloysite nanotubes (HNT) were prepared by extrusion using co-rotating twin-screw extruder and then the standard test specimens were injected using a screw injection moulding machine. The content of HNT in the nanocomposites was 5 or 10 weight percent. The heat treatment of unmodified PA6 and nanocomposites was carried out in silicone oil in temp. 150±2°C. The samples were annealed for 3 hours and then cooled at a rate of 4 K/min. Differential scanning calorimetry (DSC) causes annealing to increase the crystallinity of the polyamide matrix. After an annealing treatment a nanocomposite with better mechanical properties was obtained. Halloysite nanotubes in polyamide matrix play the role of a nucleating agent.
Two parallel life paths: Aladár Árkay and Ernő Foerk
Authors: Benárd Aurél 
Published: May 2019

Abstract
Architects Aladár Árkay and Ernő Foerk crossed the path reasonable few times, even though their course of life were parallel. Not only the place, but also the date of their birth were quite close. This fact will be the starting point to compare the two architects’ career.
Ernő Foerk’s Sacred Buildings
Authors: Nagy Gergely Domonkos 
Published: May 2019

Abstract
The article reviews Ernő Foerk’s career through the perspective of his sacred buildings. Ernő Foerk’s oeuvre accounts for a significant proportion of these works. Most of his accomplished churches were made in a Historicist style with a Latin-cross-shaped plan and facade tower. His designs which remained on paper, however, show a more diverse picture from both spatial and stylistic aspect. A number of plans were marked together with Gyula Petrovácz, however, we should presume Foerk had a more significant role in the artistic formation. In addition to the general historicist language, his works also had unique stylistic features, which were mainly related to the design of towers’ proportions, windows, pediments and spires, and to the use of bricks in facade design.
A Comparative Study of High-Resolution Chemical-Shift-Eliminated Magnetic Resonance Imaging of Finger Specimens with Microcomputed Tomography
Authors: Kwok Wingchi Edmund , You Zhigang , Monu Johnny , He Hua 
Published: May 2019

Objective: High-resolution images of finger joints with chemical-shift elimination can be obtained using an interleaved water-fat (IWF) sequence. This study assessed IWF imaging of finger joints in the delineation of bone structures by comparing images of cadaver fingers with those of microcomputed tomography (CT) that served as a standard reference.
Materials and Methods: IWF images with spatial resolution of 176 µ × 176 µ × 300 µ were obtained from the distal and proximal interphalangeal joints of two cadaver finger specimens using a custom-built radiofrequency receive coil at 1.5T. Regular three-dimensional gradient-echo (GRE) images were also acquired with similar parameters and compared with the IWF images to evaluate the effects of chemical shift. Micro-CT scans were obtained and served as the standard reference. The image data were reviewed by two experienced musculoskeletal radiologists in consensus. The delineation of normal joint structures and abnormalities in the finger specimens as revealed by the magnetic resonance imaging (MRI) and micro-CT images were compared. The IWF and regular GRE images were assigned scores 0–3 for the depiction of apparent marginal bone defects, with zero being the same in appearance to the micro-CT image and three as having minimal resemblance to it. Statistical analysis of the scoring results was conducted to compare the two MRI techniques.
Results: The high-resolution IWF images provided accurate delineation of bone and calcified structures as seen in micro-CT. The thickness of subchondral bone was depicted similarly on the IWF water + fat and the micro-CT images but not on the regular GRE images. The regular GRE sequence showed false marginal bone defects not observed with IWF and micro-CT. In addition, the IWF water-only images facilitated the identification of bone cyst by revealing its water content.
Conclusion: High-resolution IWF imaging should be useful for the early diagnosis and treatment assessment of arthritis and should also benefit basic research in the pathophysiology of the disease.
Value of the New Elastography Technique using Acoustic Radiation Force Impulse in Differentiation between Hashimoto’s Thyroiditis and Graves’ Disease
Authors: Hefeda Mohamed Mohamed 
Published: May 2019

Background and Aim: This study was performed to evaluate the role and accuracy of shear wave elastography in the differentiation between Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), in comparison with the B-mode ultrasound and color Doppler ultrasound.
Materials and Methods: This study was non-randomized prospective study. The study included 30 patients with GD, 65 patients with HT, and 35 patients with normal thyroid glands. Assessment of ultrasonographic criteria, color Doppler flow pattern, and shear patterns differed significantly between the control group and the group of diffuse thyroid disease (P < 0.001). The most specific sign for diagnosing HT was nodularity (97.87%), and the most sensitive sign was coarse echotexture (81.54%). Color Doppler flow (CDF) showed sensitivity of 91.8%, specificity of 56.92%, positive predictive value of 52.54%, negative predictive value of 92.5%, and diagnostic accuracy of 68.69% in the differentiation between GD and HT. The mean shear wave velocity (SWV) was 2.61 ± 0.32 m/s in the GD group (range: 2.1–3.21 m/s), 2.85 ± 0.52 m/s in the HT group (range: 2.31–3.82 m/s), and 1.75 ± 0.37 m/s in the control group (range: 1.24–2.36 m/s). The mean SWVs in the GD and HT groups were significantly higher than that in the control group (P < 0.001). The mean SWV in the HT group was higher than that in the GD group (P = 0.03).
Conclusion: Quantitative and qualitative SWE is useful for diagnosing diffuse thyroid disease and evaluating the degree of fibrosis in autoimmune thyroiditis. However, acoustic radiation force impulse techniques cannot differentiate between HT and GD reliably.
Estado penal, criminalização da pobreza e Serviço Social
Authors: Brisola Elisa 
Published: May 2019

O texto reflete sobre a emergência do Estado Penal em detrimento do Estado Social e o processo de criminalização dos pobres, da pobreza e dos movimentos sociais desencadeado pela crise contemporânea de acumulação do capital. Discute as formas como o processo opera junto aos segmentos pobres e movimentos sociais na sociedade brasileira, sobre os desafios postos pelo processo de criminalização dos pobres e da pobreza aos assistentes sociais, profissionais que lidam cotidianamente com as expressões da questão social e com o sofrimento dos indivíduos, famílias e movimentos sociais, que, por sua condição de classe, são discriminados e criminalizados na sociedade. Conclui que a crise do capital produz a fragilização das lutas sociais, o individualismo e a quebra da solidariedade de classes, promovendo, em última instância, a criminalização dos pobres e dos movimentos sociais.
Assistente Social nas Escolas:
Authors: Sanches Maria Socorro 
Published: May 2019

Resumo: O debate sobre a inserção de assistentes sociais nas escolas públicas vem afirmando a necessidade de atuação multiprofissional na política educacional que responda às novas demandas ampliadoras da participação social na escola. São questões emergentes que extrapolam o campo pedagógico das licenciaturas no âmbito da escola. Como contribuição a esse movimento, apresentamos neste artigo os resultados de uma pesquisa desenvolvida no Programa de Pós-Graduação do Curso de Serviço Social da Universidade Federal do Pará (UFPA), a qual, por meio do estudo de caso, investigou como crianças, usuárias da escola pública, integravam-se neste serviço a partir da análise do direito de participação nas questões que lhes dizem respeito. Para isso, analisamos as representações de criança e de infância presentes em duas escolas de periferia. Ao inventariar os achados, encontramos as lacunas e contradições nesse debate que, a nosso ver, sinalizam a importância do diálogo do assistente social com os diversos agentes envolvidos com a escola na contemporaneidade.
Ética em pesquisa, Plataforma Brasil e a produção de conhecimento em ciências humanas e sociais
Authors: Nogueira Vera Maria Ribeiro , Silva Vini Rabassa da 
Published: May 2019

Este texto tem como objetivo colaborar para o debate sobre a relação entre ética em pesquisa, sobre a Plataforma Brasil (2011) e os impactos na produção do conhecimento em ciências humanas e sociais. Inicialmente, apresenta a regulação das pesquisas no aspecto ético, informa sobre a Resolução nº 196/96 e a estruturação do Sistema Nacional de Ética em Pesquisa (Sisnep), articulando com o Conselho Nacional de Pesquisa e os Conselhos de Ética em Pesquisa. Discorre acerca das especificidades disciplinares das áreas de conhecimento e aponta os principais questionamentos e entraves que a Resolução vem provocando no âmbito das ciências humanas e sociais e as consequências práticas derivadas da mesma e da Plataforma Brasil. Concluindo, indica algumas sugestões para a revisão da Resolução nº 196/96 tendo em vista a realização de seminário nacional sobre o tema.
O HOMEM CONTEMPORÂNEO E OS SENTIDOS DE DESENVOLVIMENTO E DE EDUCAÇÃO
Authors: Ribeiro Maria Teresa Franco , Lima Iracema Dos Santos , Melo Adriana 
Published: May 2019

A partir das reflexões de Marx, da reverberação de seu pensamento em diversos autores, e da complexidade das transformações do mundo contemporâneo, centramos nossa reflexão sobre a necessidade de outros olhares sobre a questão do chamado desenvolvimento que levem em conta a educação, a formação/transformação dos sujeitos. Educação como práxis em que ação e reflexão caminham de forma solidária e se iluminam de forma constante, mutuamente. A educação é aliada fundamental no processo de reencontro e de transformação dos sujeitos do mundo, fragmentados, desqualificados e invisibilizados pela ciência moderna. Ela deve buscar a formação/transformação contínua da consciência crítica, o despertar de um vir a ser o que se é, proporcionando, aos mais diferentes sujeitos, a realização como “pessoa a tempo inteiro”, para usar a expressão de Mia Couto.