bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of psychotherapies and pharmacotherapies for Bulimia nervosa
Authors: Svaldi Jennifer , Schmitz Florian , Baur Julia , Hartmann Andrea S. , Legenbauer Tanja , Thaler Charlotte , von Wietersheim Jörn , de Zwaan Martina , Tuschen-Caffier Brunna 
Published: December 2018

AbstractBackgroundBulimia nervosa (BN), a mental disorder that causes significant impairment, can be treated with psychological, pharmacological, nutrition-based and self-help interventions. We conducted a pre-registered meta-analysis of randomized-controlled trials (RCTs) to assess the efficacy of these interventions in up to 19 different interventions.MethodsDatabase search terms were combined for BN and RCTs from database inception to March 2017. Abstinence from binge eating episodes, compensatory behaviors, the absence of a BN diagnosis and reduction of symptom severity were considered as primary outcome variables, reduction of self-reported eating pathology and depression served as secondary outcome variables. Retrieved RCTs were meta-analyzed using fixed and random effects models.ResultsRCT (79 trials; 5775 participants) effects post-treatment revealed moderate to large intervention effects for psychotherapy [mostly cognitive-behavioral therapy (CBT)] for primary outcome variables. Slightly reduced effects were obtained for self-help and moderate effects for pharmacotherapy. Similarly, psychotherapy yielded large to very large effects in regard to secondary outcome variables, while moderate to large effects were observed for self-help, Pharmacotherapy and combined therapies. Meta-analyses for the pre to post changes within group confirmed these findings. Additionally, follow-up analyses revealed the sustainability of psychotherapies in terms of large effects in primary outcome criteria, while these effects were moderate for self-help, pharmacotherapy, and combined therapies.ConclusionsMost psychological and pharmacological interventions revealed to be effective in BN treatment. Taking effect size, sustainability of the intervention, as well as the consistency of findings and available evidence into consideration, CBT can be recommended as the best intervention for the initial treatment of BN.
The devil is in the detail: exploring the intrinsic neural mechanisms that link attention-deficit/hyperactivity disorder symptomatology to ongoing cognition
Authors: Vatansever Deniz , Bozhilova Natali S. , Asherson Philip , Smallwood Jonathan 
Published: December 2018

AbstractBackgroundAttention-deficit/hyperactivity disorder (ADHD) is a developmental condition that profoundly affects quality of life. Although mounting evidence now suggests uncontrolled mind-wandering as a core aspect of the attentional problems associated with ADHD, the neural mechanisms underpinning this deficit remains unclear. To that extent, competing views argue for (i) excessive generation of task-unrelated mental content, or (ii) deficiency in the control of task-relevant cognition.MethodsIn a cross-sectional investigation of a large neurotypical cohort (n = 184), we examined alterations in the intrinsic brain functional connectivity architecture of the default mode (DMN) and frontoparietal (FPN) networks during resting state functional magnetic resonance imaging in relation to ADHD symptomatology, which could potentially underlie changes in ongoing thought within variable environmental contexts.ResultsThe results illustrated that ADHD symptoms were linked to lower levels of detail in ongoing thought while the participants made more difficult, memory based decisions. Moreover, greater ADHD scores were associated with lower levels of connectivity between the DMN and right sensorimotor cortex, and between the FPN and right ventral visual cortex. Finally, a combination of high levels of ADHD symptomology with reduced FPN connectivity to the visual cortex was associated with reduced levels of detail in thought.ConclusionsThe results of our study suggest that the frequent mind-wandering observed in ADHD may be an indirect consequence of the deficient control of ongoing cognition in response to increasing environmental demands, and that this may partly arise from dysfunctions in the intrinsic organisation of the FPN at rest.
Ships, Bread, and Work: Agrarian Conflict in the Mediterranean Countryside, 1914–1923
Authors: Hudson-Richards Julia 
Published: December 2018

AbstractThis article examines the collapse of the citrus industry in València, Spain during the last years of World War I. In it, I argue that the strikes represent a key moment in the proletarianization of the region's agricultural working classes. By 1914, citrus had become one of Spain's most profitable exports, and prior to the 1917 crash, the landed and monied interests in control of the industry had enforced the notion of inter-class cooperation, which broke down under the economic stress of the War. In the wake of the collapse and the strikes that followed, workers began to organize in earnest and began to work towards improving working conditions and establishing fairer work contracts.
“The Martyrs of the Saucepan:” Parisian Cooks, French Gastronomic Reputation, and Occupational Health around 1900
Authors: Bruegel Martin 
Published: December 2018

AbstractCooks exploited the leverage offered by the publication of information about the prevailing insalubrity in restaurant kitchens when Paris was at the center of global attention during the World Fairs of 1889 and 1900. They framed the issue of workers’ health in connection with consumer safety and gastronomic reputation. Their movement succeeded in securing the law of July 11, 1903 with its encompassing, indeed ecological and ergonomic (rather than toxicological) perception of health risks on the job. Its principles benefitted a great majority of workers and employees. The chronicle of labor's contribution to the identification and regulation of health and safety issues on the job refutes claims about the indifference of the French working-class movement with regard to workers’ health. Attention to the cooks’ workplace experience, their politics, and the elaboration of labor legislation is an antidote to the tendency of narrating state- and institution-building as the history of providential individuals with big ideas.
Making Capitalism with Gangsters: Unfree Labor in Shanghai's Cotton Mills, 1927–1937
Authors: Choi Wai Kit 
Published: December 2018

AbstractIt is thought that workers under capitalism enjoy the freedom of changing employment at will, but studies show that unfree labor has historically existed alongside capitalist development. One explanation for the use of unfree labor under capitalism highlights the functional needs of production. However, thebaoshengong, a form of bonded labor that was used in cotton mills in Shanghai from 1927 to 1937, problematizes this approach. Though thebaoshengongsystem was not an efficient mode of labor control, it was put in place. Rejecting the functionalist account, I show that capitalist unfree labor is not necessarily spurred by production requirements. As the Shanghai case will demonstrate, unfree labor was used when the power dynamics in the larger socio-political context outside the immediate abode of production—namely, the conflict and collaboration between different forms of domination such as gang, patriarchal, capitalist, and state powers—superseded the functional considerations of the capitalists.
WINNER PLAYS STRUCTURE IN RANDOM KNOCKOUT TOURNAMENTS
Authors: Cao Yang , Ross Sheldon M. 
Published: December 2018

AbstractSuppose there arenplayers, with playerihaving valuevi> 0, and suppose that a game betweeniandjis won byiwith probabilityvi/(vi+vj). In the winner plays random knockout tournament, we suppose that the players are lined up in a random order; the first two play, and in each subsequent game the winner of the last game plays the next in line. Whoever wins the game involving the last player in line, is the tournament winner. We give bounds on players’ tournament win probabilities and make some conjectures. We also discuss how simulation can be efficiently employed to estimate the win probabilities.
La Crosse virus: a scoping review of the global evidence
Authors: Harding S. , Greig J. , Mascarenhas M. , Young I. , Waddell L. A. 
Published: December 2018

AbstractUrbanisation and climate change are altering the pattern of California serogroup viruses in North America. As La Crosse virus (LACV) is the most pathogenic of the California serogroup, it is important to identify changes in distribution, transmission and pathogenesis. A scoping review (ScR) was prioritised to summarise the global evidence on LACV. A comprehensive search strategy was used, identified references were screened for relevance and relevant articles were characterised. Each step was conducted by two independent reviewers using pre-tested forms. Analysis identified areas of research saturation and gaps. The ScR included 481 research articles that were mostly journal articles (78.2%) conducted in North America (90.9%) from 1969 to 2016. Most evidence focused on epidemiology (44.9%), virus characteristics (25.8%), transmission conditions (18.7%) and pathogenesis of LACV in hosts (18.3%). Fewer studies evaluated the accuracy of diagnostic tests (8.7%), the efficacy of treatments (3.5%), prevention and control strategies (3.1%), the economic burden of infection (0.6%) and social impact (0.2%) of LACV. None of the literature predicted the impact of climate change on LACV, nor were any cases reported in Canada. These findings are intended to guide research to close knowledge gaps and inform evidence-based decisions surrounding activities for the prevention and control of LACV.
Regulation of Vascular Smooth Muscle Cell Stiffness and Adhesion by [Ca2+]i: An Atomic Force Microscopy-Based Study
Authors: Zhu Yi , He Li , Qu Jing , Zhou Yong 
Published: December 2018

AbstractThe intracellular concentration of calcium ion ([Ca2+]i) is a critical regulator of cell signaling and contractility of vascular smooth muscle cells (VSMCs). In this study, we employed an atomic force microscopy (AFM) nanoindentation-based approach to investigate the role of [Ca2+]i in regulating the cortical elasticity of rat cremaster VSMCs and the ability of rat VSMCs to adhere to fibronectin (Fn) matrix. Elevation of [Ca2+]i by ionomycin treatment increased rat VSMC stiffness and cell adhesion to Fn-biofunctionalized AFM probes, whereas attenuation of [Ca2+]i by 1,2-Bis (2-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetrakis (acetoxymethyl ester) (BAPTA-AM) treatment decreased the mechanical and matrix adhesive properties of VSMCs. Furthermore, we found that ionomycin/BAPTA-AM treatments altered expression of α5 integrin subunits and α smooth muscle actin in rat VSMCs. These data suggest that [Ca2+]i regulates VSMC elasticity and adhesion to the extracellular matrix by a potential mechanism involving changing dynamics of the integrin–actin cytoskeleton axis.
FREGE’S CONSTRAINT AND THE NATURE OF FREGE’S FOUNDATIONAL PROGRAM
Authors: PANZA MARCO , SERENI ANDREA 
Published: December 2018

AbstractRecent discussions on Fregean and neo-Fregean foundations for arithmetic and real analysis pay much attention to what is called either ‘Application Constraint’ ($AC$) or ‘Frege Constraint’ ($FC$), the requirement that a mathematical theory be so outlined that it immediately allows explaining for its applicability. We distinguish between two constraints, which we, respectively, denote by the latter of these two names, by showing how$AC$generalizes Frege’s views while$FC$comes closer to his original conceptions. Different authors diverge on the interpretation of$FC$and on whether it applies to definitions of both natural and real numbers. Our aim is to trace the origins of$FC$and to explore how different understandings of it can be faithful to Frege’s views about such definitions and to his foundational program. After rehearsing the essential elements of the relevant debate (§1), we appropriately distinguish$AC$from$FC$(§2). We discuss six rationales which may motivate the adoption of different instances of$AC$and$FC$(§3). We turn to the possible interpretations of$FC$(§4), and advance a Semantic$FC$(§4.1), arguing that while it suits Frege’s definition of natural numbers (4.1.1), it cannot reasonably be imposed on definitions of real numbers (§4.1.2), for reasons only partly similar to those offered by Crispin Wright (§4.1.3). We then rehearse a recent exchange between Bob Hale and Vadim Batitzky to shed light on Frege’s conception of real numbers and magnitudes (§4.2). We argue that an Architectonic version of$FC$is indeed faithful to Frege’s definition of real numbers, and compatible with his views on natural ones. Finally, we consider how attributing different instances of$FC$to Frege and appreciating the role of the Architectonic$FC$can provide a more perspicuous understanding of his foundational program, by questioning common pictures of his logicism (§5).
Global Estimates of Inorganic Nitrogen Deposition Across Four Decades
Authors: Ackerman Daniel , Millet Dylan B. , Chen Xin 
Published: December 2018

AbstractAtmospheric deposition of inorganic nitrogen is critical to the function of ecosystems and elemental cycles. During the industrial period, humans have doubled the amount of inorganic nitrogen in the biosphere and radically altered rates of atmospheric nitrogen deposition. Despite this rapid change, estimates of global nitrogen deposition patterns generally have low, centennial‐scale temporal resolution. Lack of information on annual‐ to decadal‐scale changes in global nitrogen deposition makes it difficult for scientists researching questions on these finer timescales to contextualize their work within the global nitrogen cycle. Here we use the GEOS‐Chem Chemical Transport Model to estimate wet and dry deposition of inorganic nitrogen globally at a spatial resolution of 2° × 2.5° for 12 individual years in the period from 1984 to 2016. During this time, we found an 8% increase in global inorganic nitrogen deposition from 86.6 to 93.6 TgN/year, a trend that comprised a balance of variable regional patterns. For example, inorganic nitrogen deposition increased in areas including East Asia and Southern Brazil, while inorganic nitrogen deposition declined in areas including Europe. Further, we found a global increase in the percentage of inorganic nitrogen deposited in chemically reduced forms from 30% to 35%, and this trend was largely driven by strong regional increases in the proportion of chemically reduced nitrogen deposited over the United States. This study provides spatially explicit estimates of inorganic nitrogen deposition over the last four decades and improves our understanding of short‐term human impacts on the global nitrogen cycle.
Emplacement and High‐Temperature Evolution of Gabbros of the 16.5°N Oceanic Core Complexes (Mid‐Atlantic Ridge): Insights Into the Compositional Variability of the Lower Oceanic Crust
Authors: Sanfilippo A. , Dick H. J. B. , Marschall H. R. , Lissenberg C. J. , Urann B. 
Published: December 2018

AbstractThis study reports the composition of the oceanic crust from the 16.5°N region of the Mid‐Atlantic Ridge, a spreading ridge segment characterized by a complex detachment fault system and three main oceanic core complexes (southern, central, and northern OCCs). Lithologies recovered from the core complexes include both greenschist facies and weathered pillow basalt, diabase, peridotite, and gabbro, while only weathered and fresh pillow basalt was dredged from the rift valley floor. The gabbros are compositionally bimodal, with the magmatic crust in the region formed by scattered intrusions of chemically primitive plutonic rocks (i.e., dunites and troctolites), associated with evolved oxide‐bearing gabbros. We use thermodynamic models to infer that this distribution is expected in regions where small gabbroic bodies are intruded into mantle peridotites. The occurrence of ephemeral magma chambers located in the lithospheric mantle enables large proportions of the melt to be erupted after relatively low degrees of fractionation. A large proportion of the dredged gabbros reveal evidence for deformation at high‐temperature conditions. In particular, chemical changes in response to deformation and the occurrence of very high‐temperature ultramylonites (>1000 °C) suggest that the deformation related to the oceanic detachment commenced at near‐solidus conditions. This event was likely associated with the expulsion of interstitial, evolved magmas from the crystal mush, a mechanism that enhanced the formation of disconnected oxide‐gabbro seams or layers often associated with crystal‐plastic fabrics in the host gabbros. This granulite‐grade event was soon followed by hydrothermal alteration revealed by the formation of amphibole‐rich veins at high‐temperature conditions (~900 °C).
Geographic Attribution of Soils Using Probabilistic Modeling of GIS Data for Forensic Search Efforts
Authors: Stern Libby A. , Webb Jodi B. , Willard Debra A. , Bernhardt Christopher E. , Korejwo David A. , Bottrell Maureen C. , McMahon Garrett B. , McMillan Nancy J. , Schuetter Jared M. , Hietpas Jack 
Published: December 2018

AbstractExaminations of soil traces associated with forensic evidence can be used to narrow potential source area(s) by characterizing features of the trace soil assemblage, some of which are limited to specific regions. Soil characteristics may be used to infer the likelihoods of the soil trace being derived from distinct areas within digital maps, including both maps of discrete classes such as formations on geologic maps and land cover, and continuous geospatial data, such as distance from a point source. Seldom do digital maps precisely represent the observable characteristics in a soil trace. Nevertheless, logical assigned likelihoods based on the correspondence between the mapped characteristics and the observed soil particulate assemblage permit creation of a model of the more probable sources of the soil trace. This approach is applied to a 2003 case in which forensic soil samples derived from digging tools were characterized for investigative leads and to narrow the search area of a clandestine grave. This grave site was located in 2005. The suspect traveled approximately 5,000 km before arrest, so narrowing the prioritized search area for law enforcement would be beneficial. Soil examination and case circumstances were used to assign relative likelihoods within digital maps (GIS or Geographic Information Systems data) of geology, soil mineralogy, plant distributions, power plant locations, and proximity to the known travel path. The product of these individual probability maps generates joint probability models to narrow the recommended search area. The digital model output can be easily overlaid on infrastructure maps to aid law enforcement searches.
The Cold Transit of Southern Ocean Upwelling
Authors: Evans Dafydd Gwyn , Zika Jan D. , Naveira Garabato Alberto C. , Nurser A. J. George 
Published: December 2018

AbstractThe upwelling of deep waters in the Southern Ocean is a critical component of the climate system. The time and zonal mean dynamics of this circulation describe the upwelling of Circumpolar Deep Water and the downwelling of Antarctic Intermediate Water. The thermodynamic drivers of the circulation and their seasonal cycle play a potentially key regulatory role. Here an observationally constrained ocean model and an observation‐based seasonal climatology are analyzed from a thermodynamic perspective, to assess the diabatic processes controlling overturning in the Southern Ocean. This reveals a seasonal two‐stage cold transit in the formation of intermediate water from upwelled deep water. First, relatively warm and saline deep water is transformed into colder and fresher near‐surface winter water via wintertime mixing. Second, winter water warms to form intermediate water through summertime surface heat fluxes. The mixing‐driven pathway from deep water to winter water follows mixing lines in thermohaline coordinates indicative of nonlinear processes.
Assessment of Finescale Parameterizations of Deep Ocean Mixing in the Presence of Geostrophic Current Shear: Results of Microstructure Measurements in the Antarctic Circumpolar Current Region
Authors: Takahashi Anne , Hibiya Toshiyuki 
Published: December 2018

AbstractThe Southern Ocean is thought to be one of globally significant mixing hotspots. In this study, we carried out simultaneous measurements of microscale turbulence and finescale shear/strain in the south of Australia to assess the validity of the existing finescale parameterizations of deep ocean mixing in the Antarctic Circumpolar Current (ACC) region where geostrophic shear flows coexist with the background internal wavefield. It is found that turbulent dissipation rates are overall small but the internal wavefield is more energetic than the Garrett‐Munk (GM) wavefield. Finescale shear/strain ratio (Rω) well exceeds the GM value in the deep layer south of the Southern ACC Front, suggesting that the local internal wave spectra are significantly biased to lower frequencies. Through the comparison of the directly measured turbulent dissipation rates with those inferred from finescale parameterizations, we find that the Gregg‐Henyey‐Polzin and Ijichi‐Hibiya parameterizations, both of which take into account the distortion of the GM frequency spectrum in terms of Rω, can predict well the turbulent dissipation rates at most of the stations, whereas the shear‐based parameterization (the strain‐based parameterization) tends to overestimate (underestimate) the directly measured turbulent dissipation rates. However, at the observation stations located on the ACC jets, both the Gregg‐Henyey‐Polzin and Ijichi‐Hibiya parameterizations tend to overestimate the turbulent dissipation rates by a factor of ∼3. The most likely cause of the overestimates is spatial anisotropy of the internal wavefield associated with large‐amplitude monochromatic near‐inertial internal waves and/or internal lee waves.
Identification of potential genetic risk factors for bipolar disorder by whole-exome sequencing
Authors: Husson Thomas , Duboc Jean-Baptiste , Quenez Olivier , Charbonnier Camille , Rotharmel Maud , Cuenca Macarena , Jegouzo Xavier , Richard Anne-Claire , Frebourg Thierry , Deleuze Jean-François , Boland Anne , Genin Emmanuelle , Debette Stéphanie , Tzourio Christophe , Campion Dominique , Nicolas Gaël , Guillin Olivier ,   The FREX Consortium
Published: December 2018

AbstractThis study aims at assessing the burden of rare (minor allele frequency < 1%) predicted damaging variants in the whole exome of 92 bipolar I disorder (BD) patients and 1051 controls of French ancestry. Patients exhibiting an extreme phenotype (earlier onset and family history of mood disorder) were preferentially included to increase the power to detect an association. A collapsing strategy was used to test the overall burden of rare variants in cases versus controls at the gene level. Only protein-truncating and predicted damaging missense variants were included in the analysis. Thirteen genes exhibited p values exceeding 10−3 and could be considered as potential risk factors for BD. Furthermore, the validity of the association was supported when the Exome Aggregation Consortium database non-Finnish European population was used as controls for eight of them. Their gene products are involved in various cerebral processes, some of which were previously implicated in BD and belong to pathways implicated in the therapeutic effect of lithium, the main mood stabilizer. However, exome-wide threshold for association study was not reached, emphasizing that larger samples are needed.