bluuebunny/crossref_metadata_2025_split huggingface dataset:
Log‐symmetric regression models: information criteria and application to movie business and industry data with economic implications
Authors: Ventura Marcelo , Saulo Helton , Leiva Victor , Monsueto Sandro 
Published: February 2019

AbstractThis work deals with log‐symmetric regression models, which are particularly useful when the response variable is continuous, strictly positive, and following an asymmetric distribution, with the possibility of modeling atypical observations by means of robust estimation. In these regression models, the distribution of the random errors is a member of the log‐symmetric family, which is composed by the log‐contaminated‐normal, log‐hyperbolic, log‐normal, log‐power‐exponential, log‐slash and log‐Student‐tdistributions, among others. One way to select the best family member in log‐symmetric regression models is using information criteria. In this paper, we formulate log‐symmetric regression models and conduct a Monte Carlo simulation study to investigate the accuracy of popular information criteria, as Akaike, Bayesian, and Hannan‐Quinn, and their respective corrected versions to choose adequate log‐symmetric regressions models. As a business application, a movie data set assembled by authors is analyzed to compare and obtain the best possible log‐symmetric regression model for box offices. The results provide relevant information for model selection criteria in log‐symmetric regressions and for the movie industry. Economic implications of our study are discussed after the numerical illustrations.
Imperfect repair in degradation processes: A Kijima‐type approach
Authors: Kahle Waltraud 
Published: February 2019

AbstractWe consider a Wiener process with linear drift for degradation modeling. Regularly, maintenance actions are carried out which produce a reduction of the degradation level. In this paper, we consider the influence of such maintenance actions to the further development of the degradation process and the resulting lifetime distribution. A connection between virtual age in Kijima‐type models and degradation level in the underlying degradation process is developed. Furthermore, estimators for the process parameters as well as for the degree of repair are developed.
LC–MS/MS method for simultaneous determination of ramelteon and its metabolite M‐II in human plasma: Application to a clinical pharmacokinetic study in healthy Chinese volunteers
Authors: Zhu Yantong , Yu Haitao , Li Tengfei , Li Duo , Ding Li , Shu Chang 
Published: February 2019

AbstractA sensitive liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous determination of ramelteon and its active metabolite M‐II in human plasma. After extraction from 200 μL of plasma by protein precipitation, the analytes and internal standard (IS) diazepam were separated on a Hedera ODS‐2 (5 μm, 150 × 2.1 mm) column with a mobile phase consisted of methanol–0.1% formic acid in 10 mm ammonium acetate solution (85:15, v/v) delivered at a flow rate of 0.5 mL/min. Mass spectrometric detection was operated in positive multiple reaction monitoring mode. The calibration curves were linear over the concentration range of 0.0500–30.0 ng/mL for ramelteon and 1.00–250 ng/mL for M‐II, respectively. This method was successfully applied to a clinical pharmacokinetic study in healthy Chinese volunteers after a single oral administration of ramelteon. The maximum plasma concentration (Cmax), the time to the Cmax and the elimination half‐life for ramelteon were 4.50 ± 4.64ng/mL, 0.8 ± 0.4h and 1.0 ± 0.9 h, respectively, and for M‐II were 136 ± 36 ng/mL, 1.1 ± 0.5 h, 2.1 ± 0.4 h, respectively.
Evaluation of a cognitive‐behavioral intervention for high‐ and medium‐risk probationers
Authors: Kosson David S. , Walsh Zach , Anderson John R. , Brook Michael , Swogger Marc T. , Verborg Robert 
Published: February 2019

AbstractReducing recidivism is a central goal of treatment programs for offenders. Preliminary evidence suggests that cognitive‐behavioral group interventions based on the National Institute of Corrections curriculum (Bush, Glick, & Taymans, 1997) may be effective in reducing recidivism rates among adult probationers. We evaluated the effectiveness of a program based on this curriculum among 167 high‐ and medium‐risk probationers assigned to this program and a comparison group of 120 high‐ and medium‐risk probationers matched on age and number of prior criminal charges. Improvements over prior studies included use of survival analytic methods and propensity score matching, a longer follow‐up interval, and examination of treatment effectiveness within ethnic groups. Relative to the comparison group, treatment group probationers were more likely to complete probation satisfactorily and survive longer before rearrest. Moreover, supplementary analyses suggested that ethnicity was associated with differences in intervention effectiveness. Treatment was predictive of lower recidivism rates among European Americans and African Americans but was less effective among Latino American probationers.
Upregulated LncRNA‐CCAT1 promotes hepatocellular carcinoma progression by functioning as miR‐30c‐2‐3p sponge
Authors: Zhang Jie , Cai Min , Jiang Dawei , Xu Liu 
Published: February 2019

Hepatocellular carcinoma (HCC) is the second leading cause of cancer‐related death over the world. It is well studied that long noncoding RNA colon cancer–associated transcript‐1 (CCAT1) played important roles in variety of cancers promoting cell proliferation and metastasis by acting as a competing endogenous RNA (ceRNA) of microRNAs. However, whether CCAT1 could regulate HCC by serving as a ceRNA of microRNA remains to be revealed. In this study, we demonstrated that CCAT1 was highly expressed in HCC tissues and remarkably associated with metastasis. With a bioinformatics prediction and functional assay validation, we found a binding site of miR‐30c‐2‐3p on CCAT1, which was important for CCAT1 to promote cell proliferation. Interestingly, we further revealed a novel recognition site for miR‐30c‐2‐3p on the 3′UTR of CCNE1 by mutative method, luciferase assay, and cell viability confirmation. In general, CCAT1 regulate the expression of CCNE1 by acting as a ceRNA to sponge miR‐30c‐2‐3p in regulating the cell proliferation of HCC. These results suggest that CCAT1 may be a new therapy target for HCC in the future.Significance of the studyOur findings may broaden the understanding of the role of CCAT1 in tumorigenesis and may provide a new therapy target for HCC.
U2AF65 enhances milk synthesis and growth of bovine mammary epithelial cells by positively regulating the mTOR‐SREBP‐1c signalling pathway
Authors: Yu Yanbo , Zhen Zhen , Qi Hao , Yuan Xiaohan , Gao Xuejun , Zhang Minghui 
Published: February 2019

U2 snRNP auxiliary factor 65 kDa (U2AF65) is a splicing factor that promotes prespliceosome assembly. The function of U2AF65 in alternative splicing has been identified; however, the essential physiological role of U2AF65 remains poorly understood. In this study, we investigated the regulatory role of U2AF65 in milk synthesis and growth of bovine mammary epithelial cells (BMECs). Our results showed that U2AF65 localizes in the nucleus. Treatment with amino acids (Met and Leu) and hormones (prolactin and β‐estradiol) upregulated the expression of U2AF65 in these cells. U2AF65 overexpression increased the synthesis of β‐casein, triglycerides, and lactose; increased cell viability; and promoted proliferation of BMECs. Furthermore, our results showed that U2AF65 positively regulated mTOR phosphorylation and expression of mature mRNA of mTOR and SREBP‐1c. Collectively, our findings demonstrate that U2AF65 regulates the mRNA expression of signalling molecules (mTOR and SREBP‐1c) involved in milk synthesis and growth of BMECs, possibly via controlling the splicing and maturation of these mRNAs. U2 snRNP auxiliary factor 65 kDa (U2AF65) is a splicing factor that promotes prespliceosome assembly. The essential physiological role of U2AF65 remains poorly understood. In the present study, we confirmed that U2AF65 functions as a positive regulator of milk synthesis in and proliferation of bovine mammary epithelial cells via the mTOR‐SREBP‐1c signalling pathway. Therefore, our study uncovers the regulatory role of U2AF65 in milk synthesis and cell proliferation.
Tetrazine‐Triggered Release of Carboxylic‐Acid‐Containing Molecules for Activation of an Anti‐inflammatory Drug
Authors: Davies Sarah , Qiao Luxi , Oliveira Bruno L. , Navo Claudio D. , Jiménez‐Osés Gonzalo , Bernardes Gonçalo J. L. 
Published: February 2019

AbstractIn addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has emerged as a promising strategy to enable protein or drug activation in a spatially and temporally controlled manner. This study demonstrates the application of a bioorthogonal inverse electron‐demand Diels–Alder (iEDDA) reaction to cleave trans‐cyclooctene (TCO) and vinyl protecting groups from carboxylic acid‐containing molecules. The tetrazine‐mediated decaging reaction proceeded under biocompatible conditions with fast reaction kinetics (<2 min). The anti‐inflammatory activity of ketoprofen was successfully reinstated after decaging of the nontoxic TCOprodrug in live macrophages. Overall, this work expands the scope of functional groups and the application of decaging reactions to a new class of drugs.
Cutaneous lymphangioma circumscriptum: The relevance of clinical, dermoscopic, radiological, and histological assessments
Authors: Gomides Mabel D. A. , Costa Laís D. , Berbert Alceu L. C. V. , Janones Renata S. 
Published: February 2019

Key Clinical MessageCutaneous lymphangioma circumscriptum (CLC) is a rare congenital malformation of the superficial cutaneous lymphatic ducts. Case report: A 7‐year‐old boy presented plaque with grouped vesicles resembling a “frog spawn” on the upper left thigh, since 4 months old. The clinical, dermatoscopic and histopathological correlation is of great importance.
Recurrent prolapse of toric implantable collamer lens after blunt ocular trauma under mesopic conditions
Authors: Takagi Yuki , Nakamura Tomoaki , Ichikawa Kazuo , Kojima Takashi 
Published: February 2019

Key Clinical MessageImplantable collamer lenses (ICL) carry a risk of prolapse caused by direct ocular trauma, especially in mesopic conditions and when oversized ICLs are implanted. We recommend early surgical repositioning, as well as patient education that encourages goggle use during active sports.
Cobalt‐Catalyzed Cross‐Couplings and Electrophilic Aminations using Organozinc Pivalates
Authors: Lutter Ferdinand H. , Graßl Simon , Grokenberger Lucie , Hofmayer Maximilian S. , Chen Yi‐Hung , Knochel Paul 
Published: February 2019

AbstractTransition metal catalyzed cross‐couplings are essential methods in organic synthesis. Due to their comparable low toxicity and price, cobalt‐salts offer a useful alternative to other common metal‐catalysts (e. g. palladium‐complexes). In this review, we report that cobalt‐catalysts are especially well suited for cross‐coupling reactions with organozinc pivalates, a class of organozinc reagents with enhanced stability towards air and moisture. Furthermore, we discuss applications of cobalt‐catalysis in Negishi cross‐coupling reactions (sp2‐sp2, sp‐sp2, sp‐sp3) as well as electrophilic aminations using organozinc reagents.
Bimetallic Co2+ and Mn2+ Hexacyanoferrate for Hydrogen Peroxide Electrooxidation and Its Application in a Highly Sensitive Cholesterol Biosensor
Authors: Antuch Manuel , Matos‐Peralta Yasser , Llanes Dayma , Echevarría Frank , Rodríguez‐Hernández Joelis , Marin Milenen Hernández , Díaz‐García Alicia M. , Reguera Leslie 
Published: February 2019

AbstractIn this work, we report the synthesis and characterization of a bimetallic Prussian blue analogue containing Co and Mn as outer‐sphere metals (CoMnHCF). The material was a solid solution and its characterization revealed a chemical composition of Co2.05Mn0.95[Fe(CN)6]2 ⋅ 12H2O. The electrochemistry of this novel material showed the existence of two redox waves displaying quasi‐reversible kinetics, as expressed by the larger peak‐to‐peak separation upon increasing the potential sweep rate. Interestingly, the CoMnHCF solid exhibited high electrocatalytic activity for the oxidation of hydrogen peroxide, thus representing an appealing scaffold for the construction of biosensors. As a proof of concept, cholesterol oxidase was immobilized at the electrode surface by using a sol‐gel method, and the cyclic voltammograms were recorded at increasing concentrations of cholesterol. The biosensor showed a detection limit of 30 μM and two linear ranges with excellent sensitivity of 385 mA cm−2 M−1 between 50 and 150 μM, and an adequate sensitivity of 80 mA cm−2 M−1 between 150 and 1 mM. To the best of our knowledge, this is the first biosensor application of a pre‐synthesized bimetallic hexacyanometallate, thus exploiting its potential as an H2O2 electrooxidation catalyst.
Unconventional Approaches to Hydrogen Sorption Reactions: Non‐Thermal and Non‐Straightforward Thermally Driven Methods
Authors: Ares Jose‐Ramón , Nevshupa Roman , Muñoz‐Cortés Esmeralda , Sánchez Carlos , Leardini Fabrice , Ferrer Isabel‐J. , Minh Huy Tran Vo , Aguey‐Zinsou Francois , Fernández Jose‐Francisco 
Published: February 2019

AbstractIn the last decades, a broad family of hydrides have attracted attention as prospective hydrogen storage materials of very high gravimetric and volumetric capacity, fast H2‐sorption kinetics, environmental friendliness and economical affordability. However, constraints due to their high activation energies of the different H2‐sorption steps and the Gibbs energy of their reaction with H2 has led to the need of high thermal energy to drive H2 uptake and release. High heat leads to significant degradation effects (recrystallization, phase segregation, nanoparticles agglomeration…) of the hydrides. In this context, this short review aims to summarize alternative non‐thermal methods and non‐straightforward thermally driven methods to overcome the previous constraints. The phenomenology lying behind these methods, i. e. tribological activation, sonication, and electromagnetic radiation, and the effect of these processes on hydrogen sorption properties of hydrides are described. These non‐usual approaches could boost the capability of the next generation of solid‐hydride materials for hydrogen conversion in energy sector, in mobile devices and as hydrogen reservoirs.
Room‐Temperature Synthesis of Germanium Oxide Nanofilaments and Their Potential Use as Luminescent Self‐Cleaning Surfaces
Authors: Saddiqi Naeem‐ul‐Hasan , Patra Debabrata , Seeger Stefan 
Published: February 2019

AbstractThe front cover artwork is provided by the group of Prof. Stefan Seeger (University of Zurich). The image shows water droplet assisted formation of a 1D nanofilament structure composed of germanium oxide governed by droplet assisted growth and shaping droplet assisted growth and shaping method. Read the full text of the Article at 10.1002/cphc.201800964.
A case of aortic valve leaflet tear and perforations after neocuspidization
Authors: Makino Masato , Yamamoto Hiroyuki , Ishibashi‐Ueda Hatsue , Nakamura Yoshitsugu 
Published: February 2019

AbstractAlthough aortic valve (AV) replacement is a curative procedure for severe aortic stenosis, prosthetic heart valves have many disadvantages and cause serious complications. A new promising surgical procedure—aortic valve neocuspidization (AVNeo)—has recently been developed; it is an original method of AV reconstruction with autologous pericardium. It has been reported to yield excellent medium‐term results with respect to durability and complications. Herein, we encountered a first case of AV leaflet tear and perforations 27 months after AVNeo using autologous pericardium. AV leaflet tear or perforation is well recognized as a long‐term serious complication of pericardial xenografts. Interestingly, however, AVNeo caused early structural valve deterioration in the current case. In the present case, an eccentric aortic regurgitation jet observed on colour flow imaging led us to reach the correct diagnosis. Finally, the patient showed complete recovery with redo AV replacement. This case highlights the importance of understanding the potential pitfalls of this new surgical technique and that of colour Doppler echocardiography in reaching a definite diagnosis.
Klotho, fibroblast growth factor‐23, and the renin–angiotensin system — an analysis from the PEACE trial
Authors: Bergmark Brian A. , Udell Jacob A. , Morrow David A. , Jarolim Petr , Kuder Julia F. , Solomon Scott D. , Pfeffer Marc A. , Braunwald Eugene , Sabatine Marc S. 
Published: February 2019

AimsKlotho, an essential co‐receptor for fibroblast growth factor (FGF)‐23, has potentially beneficial inhibitory effects on the renin–angiotensin system. Limited data exist on the prognostic value of Klotho and FGF‐23 levels in combination or their ability to predict benefit from angiotensin‐converting enzyme (ACE) inhibition.Methods and resultsA total of 3555 patients with stable ischaemic heart disease and left ventricular ejection fraction > 40% enrolled in the PEACE trial of trandolapril vs. placebo had Klotho levels drawn at randomization. Patients were characterized by quartiles of Klotho and FGF‐23 concentrations. Six‐year Kaplan–Meier rates and adjusted risk were calculated in the placebo arm for the composite of cardiovascular (CV) death or hospitalization for heart failure and its components. Low [quartile (Q) 1–3] Klotho concentration was associated with an increased rate of CV death or hospitalization for heart failure as compared with Q4 (8.2% vs. 4.2%; P = 0.03). After multivariable adjustment for clinical variables and renal and CV biomarkers (estimated glomerular filtration rate, cystatin‐C, urine albumin‐to‐creatinine ratio, FGF‐23, high‐sensitivity troponin T, N‐terminal pro‐B‐type natriuretic peptide, and high‐sensitivity C‐reactive protein), low Klotho concentration remained strongly associated with increased risk of CV death or hospitalization for heart failure [adjusted hazard ratio (HR) 2.62; 95% confidence interval (CI) 1.35–5.08; P < 0.01]. The combination of low Klotho and high (Q4) FGF‐23 concentration identified patients at particularly elevated risk (adjusted HR 3.99; 95% CI 1.67–9.56; P < 0.01). This high‐risk combination additionally predicted benefit from trandolapril (HR 0.39; 95% CI 0.23–0.68; Pinteraction < 0.01).ConclusionsLow Klotho concentration is associated with an increased risk of CV death or heart failure hospitalization in patients with stable ischaemic heart disease. The combination of low Klotho and high FGF‐23 further identifies patients at distinctly elevated risk who derive clinical benefit from the ACE‐inhibitor trandolapril.
Multi‐objective optimization of solar‐aided coal‐fired power generation system under off‐design work conditions
Authors: Wang Jianxing , Duan Liqiang , Yang Yongping , Pang Liping , Yang Laishun 
Published: February 2019

AbstractSolar‐aided coal‐fired power generation (SAPG) has been attracting more and more attentions in recent years. However, the multi‐objective optimization of SAPG system considering off‐design work conditions has not been fully studied. In this paper, a general system integration optimization method (GIOM) has been developed for integration schemes optimization, and Nondominated Sorting Genetic Algorithm‐II (NSGA‐II) algorithm is used for multi‐objective optimization of SAPG system. As a case study, a SAPG system that refers to a real 600 MWe supercritical coal‐fired power plant is optimized based on a typical day. By simultaneous optimization of both initial investment (P) and solar net electric generation (Esolar), the solar subsystem design schemes are optimized as Pareto optimal set. At last, to maximum Esolar/P, the final design scheme is selected from the Pareto optimal set, whose Esolar and P are 237.6 MWh and 113.5 M$, respectively. The results show that, the final design scheme is a heliostat field with instantaneous optical efficiency of 63.24% at the design point, the receiver power rating is 133 MWt, the tower height is 136.6 m, and distances of successive rows of the three zones are 13.6, 17.7, and 24.5 m, respectively. A larger or smaller size of solar subsystem is considered to be uneconomical.
A proposal for updating the staging of endometrial cancer
Authors: Maheshwari Amita , Gupta Sudeep , Prat Jaime 
Published: February 2019

AbstractSince the last update of the International Federation of Gynecology and Obstetrics (FIGO) staging for corpus uteri cancer in 2009, a number of new insights into pathology, molecular genetics, and prognostic factors that justify a revision have been made. We recommend incorporation of histotype and grade along with depth of myometrial invasion to define stage I endometrial cancer, a change from 3‐tier grading to binary grading, and inclusion of lymph node status (negative vs not removed) in the definition of stage I disease. Elimination of cervical involvement to define stage II and inclusion of positive peritoneal cytology to upstage otherwise stage I cancers to stage IIA is also recommended. Extrauterine pelvic involvement should be classified as stage IIB disease, and stage III should be reclassified based exclusively on retroperitoneal pelvic and/or para‐aortic lymph node involvement. If feasible, molecular staging by immunohistochemistry (mismatch repair proteins and p53) as well as POLE exonuclease sequencing may be carried out in order to assign one of the four categories from The Cancer Genome Atlas.
The Role of ERP Capabilities in Achieving Competitive Advantage: An Empirical Study on Dakahlia Governorate Companies, Egypt
Authors: Elgohary Esam 
Published: February 2019

AbstractNowadays enterprise resource planning (ERP) systems are crucial for each company to automate and manage its business seamlessly and possess a competitive advantage. This paper was conducted with the purpose of determining which ERP capabilities categorized in IT capabilities, including integration, information access, IT skills and agility, and organizational capabilities including qualified human resources, top management support can affect decision‐making efficiency and competitive advantage types (low cost advantage and/or differentiation advantage), it also examines the impact of decision‐making efficiency on competitive advantage types. The problem of this paper is summarized in the uncertainty of the relationship between ERP capabilities and competitive advantage, as well as the absence of studies in this field. So, a survey was applied on 162 companies in Dakahlia Governorate, Egypt in order to investigates the impact of ERP capabilities on low‐cost advantage, differentiation advantage, and decision making efficiency, in order to determine whether each category of ERP capabilities can affect any competitive advantage type and decision‐making efficiency in itself or they must be combined with each other to occur impact, and finally examine the decision making efficiency impact on competitive advantage types.