bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trace Extraction of Metoprolol from Plasma, Urine and EBC Samples Using Modified Magnetic Nanoparticles Followed by Spectrofluorimetric Determination for Drug Monitoring Purposes
Authors: Tarfiei Mohammad Ali , Tabrizi Ahad Bavili , Jouyban Abolghasem 
Published: April 2019

Background:
Metoprolol is a selective β1-adrenergic receptor antagonist (β-blockers). It is
widely used for the treatment of hypertension and other related diseases. Metoprolol can be used as a
doping agent in sports, thus has been included in the list of forbidden drugs. In Iran, therapeutic drug
monitoring (TDM) of β-blockers is an applied procedure in some cases. A therapeutic regimen could be
easily managed by the determination of drug levels in biological fluids which is a relatively costly process
and requires highly skilled technical staff. Using a simple and low-cost analytical procedure may
help to use TDM in routine clinical practice.

Methods:
A real biological sample was prepared and its pH was adjusted to 3-4, then metoprolol was
quickly extracted using magnetic iron oxide nanoparticles (MIONPs) modified by sodium dodecyl sulfate
(SDS) and determined by applying spectrofluorimetry at 340 ± 3 nm after excitation at 283 ± 3 nm.

Results:
The extraction and determination conditions including, the amount of MIONPs and SDS, pH of
the solution, standing time, desorption solvent type and volume were investigated and adjusted. Calibration
curves were linear over the concentration range of 6–100 ng/mL for plasma and 5–100 ng/mL for
water, urine and exhaled breath condensate samples, respectively. Intra and inter-day precision values
for determination of metoprolol in different samples were less than 5.6 % and 6 %, respectively, and
accuracy (as a relative error) was better than 5 %. Moreover, standard addition recovery tests were carried
out, and the analytical recoveries ranged from 86 % to 113 %. The limits of detection (LOD) and
limits of quantification (LOQ) of metoprolol were found to be in the range of 2.1-3.4 ng/mL and 6.3-
10.2 ng/mL, respectively.

Conclusion:
The developed method was successfully applied to biological samples taken from a volunteer
who was given an oral tablet of 50 mg metoprolol.
The Scalability of Wet Ball Milling for The Production of Nanosuspensions
Authors: Lestari Maria L.A.D. , Müller Rainer H. , Möschwitzer Jan P. 
Published: April 2019

Background:
Miniaturization of nanosuspensions preparation is a necessity in
order to enable proper formulation screening before nanosizing can be performed on a
large scale. Ideally, the information generated at small scale is predictive for large scale
production.

Objective:
This study was aimed to investigate the scalability when producing nanosuspensions
starting from a 10 g scale of nanosuspension using low energy wet ball milling up to
production scales of 120 g nanosuspension and 2 kg nanosuspension by using a standard
high energy wet ball milling operated in batch mode or recirculation mode, respectively.

Methods:
Two different active pharmaceutical ingredients, i.e. curcumin and hesperetin,
have been used in this study. The investigated factors include the milling time, milling
speed, and the type of mill.

Results:
Comparable particle sizes of about 151 nm to 190 nm were obtained for both active
pharmaceutical ingredients at the same milling time and milling speed when the drugs
were processed at 10 g using low energy wet ball milling or 120 g using high energy wet
ball milling in batch mode, respectively. However, an adjustment of the milling speed was
needed for the 2 kg scale produced using high energy wet ball milling in recirculation
mode to obtain particle sizes comparable to the small scale process.

Conclusion:
These results confirm in general, the scalability of wet ball milling as well as
the suitability of small scale processing in order to correctly identify the most suitable formulations
for large scale production using high energy milling.
The Use of Montmorillonite (MMT) in Food Nanocomposites: Methods of Incorporation, Characterization of MMT/Polymer Nanocomposites and Main Consequences in the Properties
Authors: Vilarinho Fernanda , Vaz Malia Fátima , Silva Ana Sanches 
Published: April 2019

Background:
The clay Montmorillonite (MMT) is among the nanofillers more frequently
used in food packaging. The uniform dispersion of nanoparticles in polymers confers considerable
improvement of mechanical, thermal, optical, and/or barrier properties in polymer/clay
nanocomposites.

Objective:
The aim is to ascertain the state of the art of the use of MMT for packaging purposes,
with special emphasis on food applications.

Methods:
A literature review was carried out through recent papers and patents that focused on the
incorporation of MMT in polymers.

Results:
This review emphasizes the interaction of MMT with polymers and their levels of incorporation
in the nanocomposites. This work also highlights the analytical methodologies used for the
characterization of the polymer/clay nanocomposites and the main consequences of the fillers in the
properties of nanocomposites. Challenges remain about increasing the compatibility between clays
and biopolymers to promote their utilization in food packaging. New strategies for immobilization
of oxides, enzymes, essential oils, and other bioactive compounds are needed.

Conclusion:
MMT-based composite materials are promising to be used in intelligent and active
packaging.
Low Cost and Centimeter-Level Global Positioning System Accuracy Using Real-Time Kinematic Library and Real-Time Kinematic GPSA
Authors: Gianey Hemant K. , Ali Mumtaz , Vijayakumar Varadarajan , Sharma Ashutosh , Kumar Rajiv 
Published: April 2019

Introduction:
Accuracy and total design and implementation cost of the GPS framework
determine the viability of GPS based projects. As the greater part of the advanced framework including
telemetry, IoT, Cloud, and AUTOSAR frameworks use GPS to get exact outcomes, finding a
software-controlled error correction becomes important. The execution of open source library such
as RTKLIB will help in controlling and revising GPS blunders.

Methods:
The project utilizes the RTKLIB along with two stations for better accuracy. The RTKGPS
framework works under Linux environment, which is embedded in the Beagleboard. The
communication between the GPS system is set up utilizing both serial communication protocol and
TCP/IP suite.

Results:
To get high precision inside the network, two GPS modules are utilized. One of them will
be mounted on the rover and another GPS is the base station of the setup. Both the GPS will have a
double radio wire setup to increase the reception level to reduce the noise and obtain centimeterlevel
precision. For long-range communication, rover utilizes Wi-Fi with TCP/IP stack protocol. In
this research paper, setup is intended to accomplish the centimeter level precision through libraries
in a Linux environment.

Conclusion:
The design will be set up and tried on a college campus under various conditions with
different error parameters to acquire a low cost and centimeter level GPS accuracy.
Pose and Illumination Invariant Hybrid Feature Extraction for Newborn
Authors: Singh Rishav , Singh Ritika , Acharya Aakriti , Tiwari Shrikant , Om Hari 
Published: April 2019

Background:
Abduction, swapping and mix-ups are the unfortunate events that could
happen to Newborn while in hospital premises and medical personnel are finding it difficult to curb
this unfortunate incident. Accurate patient identification (ID) is essential for patient safety, especially
with our smallest and most vulnerable paediatric patients.

The level of security is very crucial issue in maternity ward and the problem of missing and swapping
of Newborn is of prime concern to the persons involved and affected. There is a common perception
in the society that nothing can be done to prevent this unfortunate tragedy. In comparison to
developed nations the developing countries are facing more challenges because of overcrowding and
scarcity of medical facilities in the hospital. The face of a newborn baby changes appearance in different
lighting conditions in spite of various contrast enhancement techniques. The class of images
which are under similar environment conditions (inter-class) may result in more differences than
that of the intra-class images under different illumination conditions. This gives rise to the misclassification
of images.

Objective:
The main objective of this paper is perform newborn face recognition in a hybrid approach.
Speeded Up Robust Features (SURF) and Local Binary Pattern (LBP).

Methods:
The scientific contributions of the proposed work are stated below:

For face recognition of newborns in a semi controlled environment.

Overcoming the pose and illumination challenge.

Uses single gallery image.

Uses a hybrid approach to improve the results.

Conclusion:
In this paper new semi supervised technique is used for demonstrate the improve the performance
of the newborn face recognition system in different illumination and pose conditions. In our.

Results:
The average Rank 1 accuracy of the proposed method is 93.65% whereas that of the existing
algorithms is quite low. The proposed technique is 12.8% more accurate than LBP, 10.5% more
accurate than SURF, 12.8% more accurate than LDA and 18.1% more accurate than PCA for rank1.
Recent Contributions of Nuclear Magnetic Resonance in Organocatalysis Mechanism Elucidation
Authors: De Carvalho Gustavo Senra Gonçalves , Granato Álisson Silva , De Castro Pedro Pôssa , Amarante Giovanni Wilson 
Published: April 2019

Background:
Nuclear Magnetic Resonance (NMR) is one of the most employed techniques
in structural elucidation of organic compounds. In addition to its use in structural characterization,
it has been widely employed in the investigation of reaction mechanisms, especially those involving
catalysis.

Objective:
In this review, we aim to provide recent examples of the interface of NMR and organocatalysis
reaction mechanism.

Methods:
Selected examples of different approaches for mechanism elucidation will be presented,
such as isotopic effect, catalyst labelling and online reaction monitoring. A discussion involving the
use of solid-state NMR will also be disclosed.

Conclusion:
NMR consists of a non-destructive technique, extremely useful in the real-time identification
of intermediates in crude reaction mixtures. With the advent of two-dimensional experiments
and high field NMR spectrometers, the reports of studies involving mechanistic elucidation were
greatly enhanced. In this context, nowadays NMR appears as a powerful tool for the comprehension
of reaction mechanisms, including the possibility of the proposal of unknown reaction mechanisms
within organocatalysis.
ИНОВИРАНИ ПРИСТУП У ОБРАЗОВАЊУ ВАСПИТАЧА И САМОЕВАЛУАЦИЈА ЊИХОВИХ МУЗИЧКИХ КОМПЕТЕНЦИЈА
Authors: Grujic Garic Gabrijela , Sokolovic Ignjacevic Maja 
Published: April 2019

The process of educating preschool teachers in Serbia over the past decades has been carried out within the framework of three-year vocational programs. Ten years ago Teacher Education Faculties offered academic, four – year long studies for preschool teachers. Curricula and programs in all areas, including music, have been constantly modificated, improved and adapted to the needs of practice. The aim of this study was to determine whether there is a statistically significant difference between self-assessment of musical competences – general and individual (instrument playing skills, knowledge of musical notation, as well as basic methodological steps in music activities) between educators who have just completed academic studies and those who already work at Serbian preschools an have mainly attended vocational studies. Our primary purpose was to ascertain whether the various innovations introduced within the curricula of musical subjects in the academic studies have positively influenced the teachers’ perception of their own musical competencies. The research has confirmed the impact of educational programs for music teachers on the self-assessment of their musical competencies and knowledge in this field. There was a statistically significant difference between the responses of the experimental and control groups in favor of experimental in all key areas: general self-assessment of music competences, self-assessment of specific skills – music-playing skill and music literacy, content selection criteria, methodological procedures.
ИЗАЗОВИ И АЛТЕРНАТИВЕ ЗА ПОСТИЗАЊЕ ОДРЖИВОГ РАЗВОЈА ЗАШТИЋЕНИХ ПОДРУЧЈА И КОМОНСА У СРБИЈИ ОСЛОЊЕНИ НА ФИНАНСИЈСКУ АНАЛИЗУ И УПРАВЉАЧКЕ ОПЦИЈЕ
Authors: Кочовић Милица , Јовичић Елена , Бабић Јасна 
Published: April 2019

The subject of the research paper is focused on the recommendations for alternative financing and management with the aim of achieving sustainable development of protected areas and the commons. For the need of research paper we have conducted financial analysis of operations of the national parks, which pointed out one of the challenges for sustainable (economic and environmental) development of protected areas in Serbia. We have taken into account the multi-year period, with the aim of assessment of the financial position in order to give recommendations that may provide sustainable development of national parks. Financial analysis conducted in this paper refers to the measurement of financial performances, the financial position and operations efficiency of the national parks with particular emphasis on NP Djerdap and related commons. The basic objective of this analysis is reflected in the consideration of weakness (which can lead to the illiquidity and insolvency of NP Đerdap in the future), with the goal of timely undertaking adequate measures for their elimination ensuring sustainable development. The second challenge is concerned with the essential similarities and differences in terms of management, responsibilities, protection, rights to use national parks as examples of protected areas, and the associated heritage as examples of commons. Different perspectives on these phenomena closely confirm the direction of management recommendations.In relation to the identified financial and management challenges, the main objective of the paper is to give recommendations for an alternative system solutions that reflects through the establishment the financial and management sustainability of national parks and associated heritage.
CORRIGENDUM
Authors: Team Editorial 
Published: April 2019

In the Journal Teme, XLII, No 4, October - December, 2018. in the article:Mirjana Gligorić, Biljana Jovanović Gavrilović, Ljubodrag Savić PROSPERITY INDEX AS A MEASURE OF WELLBEING IN EUROPEAN UNION AND WESTERN BALKAN COUNTRIESТEME, XLII, No. 4, October - Dеcember 2018, pp. 1253-1275 https://doi.org/10.22190/TEME1804253Gin pdf and printed version of article wrong data has been published in chapter References.The Editor-in-Chief has decided to publish a corrigendum for this article. Corrected references:http://teme2.junis.ni.ac.rs/index.php/TEME/article/view/1153 Link to the corrected article: http://teme2.junis.ni.ac.rs/index.php/TEME/article/view/841https://doi.org/10.22190/TEME1804253G
Estudio de una familia de funciones de periodo tres y su dinámica caótica
Authors: Macías Ponce Julio César , Martínez Álvarez Luis Fernando 
Published: April 2019

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><strong>Objetivo - </strong><span>construir sistemas dinámicos caóticos unidimensionales mediante el estudio de una familia de funciones con dominio y contradominio en el intervalo [0,1] la cual se define en términos de cuatro parámetros.</span></p><p><strong>Método - </strong><span>con base a los parámetros que definen a cada función que proponemos, se identificaron aquellas que tienen periodo tres, las cuales inducen un sistema caótico en el contexto de Li-Yorke. Los teoremas del punto fijo y de Sharkovskii fueron la herramienta fundamental de nuestro trabajo. </span></p><p><strong>Resultados - </strong><span>se obtuvo un conjunto de sistemas dinámicos caóticos, se describió un procedimiento sencillo para obtener sistemas dinámicos caóticos (adicionales a los obtenidos) y se sugiere como primera aplicación la obtención de números pseudoaleatorios.</span></p><p><strong>Limitaciones - </strong><span>los sistemas dinámicos construidos son caóticos en el sentido de Li-Yorke, -no necesariamente en el sentido de Devaney-. </span></p><p><strong>Principales hallazgos - </strong><span>las funciones estudiadas tienen una gráfica </span><span>en <em>forma de Zeta</em></span><span>, y para cada una de ellas se identifica a su respectiva </span><em>dual </em><span>(las gráficas que se obtienen presentan una relación de simetría), de esta manera se muestran las condiciones que deben verificar los parámetros -primal y dual- para obtener (y no obtener) período tres. </span></p></div></div></div>
EDUCAÇÃO INCLUSIVA: um estudo sobre a percepção dos professores de uma escola em Espinosa – MG
Authors: Campos Ertz Ramon Teixeira , Rodrigues Humberto Gabriel , Macedo Helen Cristhianne de Oliveira , Sá Aliny Cristiany Cardoso de , Oliveira Francisco Malta de , Beirão Éder de Souza 
Published: April 2019

O processo de inclusão do aluno com deficiência em classes comuns da rede regular ainda requer muitas mudanças na gestão educacional por parte do Estado, que funciona como um exemplo da sociedade, dando uma visão geral de como ela é, ressaltando uma importante missão da escola que é a de proporcionar relacionamentos em um ambiente de interação. A prática em sala de aula não atende efetivamente as necessidades dos alunos no processo de inclusão e um dos motivos que contribuem para isso é a falta de adaptação do currículo por parte da escola. Este estudo proporcionou um olhar mais atento no que envolve a realidade da educação inclusiva nas escolas e também trouxe para mais perto a realidade vivenciada nas escolas da rede regular.
Palavras-chave: Inclusão. Gestão educacional. Interação. Educação Inclusiva.

INCLUSIVE EDUCATION: a research on the perception of the teachers of a school in Espinosa – MG
ABSTRACT
The process of inclusion of the disabled student in common classes of the regular network still requires many changes in the educational management by the State, which functions as an example of society, giving an overview of how it is, highlighting an important mission of the school that is to provide relationships in an interaction environment. Classroom practice does not effectively meet the needs of students in the inclusion process and one of the contributing factors is the school's lack of adaptation of the curriculum. This study provided a closer look at what is involved in the reality of inclusive education in schools and also brought the reality of schools in the regular network closer.
Keywords: Inclusion. Educational management. Interaction. Inclusive education.

EDUCACIÓN INCLUSIVA: un estudio sobre la percepción de los profesores de una escuela en Espinosa – MG
RESUMEN
El proceso de inclusión del estudiante con discapacidad en clases comunes de la red regular todavía requiere muchos cambios en la gestión educativa por parte del Estado, que funciona como un ejemplo de la sociedad, dando una visión general de cómo es, resaltando una importante misión de la escuela que es la de proporcionar relaciones en un ambiente de interacción. La práctica en el aula no atiende efectivamente las necesidades de los alumnos en el proceso de inclusión y uno de los motivos que contribuyen a ello es la falta de adaptación del currículo por parte de la escuela. Este estudio proporcionó una mirada más atenta en lo que implica la realidad de la educación inclusiva en las escuelas y también trae para más cerca la realidad vivida en las escuelas de la red regular.
Palabras-clave: La inclusión. Gestión educativa. Interacción. Educación inclusiva
Interacciones entre hongos formadores de micorrizas vesiculo-arbusculares (VAM) y Bradyrhizobium; su efecto en el crecimiento de la soja (Glicine max)
Authors: Cabello Marta 
Published: April 2019

Se estudió la interacción entre hongos VAM nativos de suelos agrícolas de la provincia de Buenos Aires (Argentina), Glomus epigaeus y Bradyrhizobium japonicum en plantas de soja. La inoculación tripartita: VAM nativas, G. epigaeus y B. japonicum produjeron plantas más vigorosas, con mayor número de nódulos y de mayor tamaño en relación a plantas no inoculadas. El contenido de Nitrógeno en la porción aérea de las plantas aumentó un 102% y el del Fósforo un 233% en las plantas con inoculación tripartita, en relación al testigo no inoculado.
Introducción a la Virología I
Authors: Peña Cindy , Faúndes G. Nicolás 
Published: April 2019

Los virus han acompañado al hombre a través de toda su historia, provocando infecciones y plagas que han generado la muerte y el temor de poblaciones completas. Muchos han sido los investigadores que han contribuido a conocer la estructura, patogenia e inmunidad involucrada. Es fundamental conocer los aspectos básicos de los virus para entender la enfermedad y el tratamiento, por lo que esperamos contribuir a esto con los apuntes que a continuación presentamos.
Morbidity and Mortality Rates from Digestive Diseases in the RF Northwestern Federal District (NWFD) and Measures to Reduce Them
Authors: Baranovsky Andrey Yu. , Belyaev Alexey M. , Kondrashina Elina A. 
Published: April 2019

Aim: to analyze the dynamics of morbidity and mortality from digestive diseases, as well as their causes, in the RF Northwestern Federal District (NWFD).Materials and methods. A statistical analysis was carried out on the basis of the 2007–2017 annual reports of the Medical Information and Analytical Center (MIAC) in St. Petersburg and the reports of the chief gastroenterologists of the Northwestern Federal District subjects.Results. In the RF Northwestern Federal District, an increase in both morbidity and mortality from digestive diseases is observed. The main non-oncological reasons for the development of these disorders include alcoholic liver disease, chronic alcoholic pancreatitis, peptic ulcer complications and NSAID-associated gastropathies. Along with a decrease in the incidence of gastric cancer, an increase in the incidence of colorectal cancer, as well as pancreatic cancer, is observed. A decrease in mortality from all the aforementioned cancer localizations is revealed.Conclusions. The main reasons for the increase in morbidity and mortality due to gastroenterological diseases in the RF Northwestern Federal District include alcohol abuse among the population, inadequate prevention of gastric helicobacteriosis, insufficient expertise of physicians in terms of Helicobacter pylorieradication and cancer prevention.
PREVALENCIA DE FISURA LABIOPALATINA EN EL HOSPITAL DEL NINO – LA PAZ DE 2016 HASTA SEPTIEMBRE DE 2017
Authors: MEAVE DANIEL , Chavez Carrillo Carenina , Arostegui Bustillos Luis , Romero Fernandez Rafael 
Published: April 2019

Las fisuras labiopalatinas son las anomalías faciales congénitas más frecuentes presentándose en 1/700 RN vivos. Existen muchos factores de riesgo desde predisposición genética o factores ambientales y estilos de vida.
Metodología: Método retrospectivo con muestra de población niños con fisura labiopalatina que acudieron al servicio de Cirugía Plástica del hospital del niño en La Paz basado en revisión de historias clínicas de todos los pacientes que acudieron durante el 2016 hasta septiembre de 2017
Resultados: En 2016, prevaleció con 16,6% en niñas de la ciudad de El Alto con fisura unilateral izquierda. En 2017 prevaleció, niños con fisura unilateral derecha e izquierda con 9.52% y niñas con fisura unilateral izquierda con 9.52% de la ciudad de La Paz.
Conclusiones: En la revisión se constató que mayor porcentaje se da en la ciudad de El Alto, así mismo, en relación al sexo prevalece en mujeres siendo unilateral izquierda sobretodo.
Palabras clave: Fisura labiopalatina, prevalencia.