bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macrophage stimulating protein preserves blood brain barrier integrity after intracerebral hemorrhage through recepteur d'origine nantais dependent GAB1/Src/β‐catenin pathway activation in a mouse model
Authors: Lu Tai , Wang Zhong , Prativa Sherchan , Xu Yang , Wang Tian , Zhang Yiting , Yu Lingyan , Xu Ningbo , Tang Jiping , You Wanchun , Chen Gang , Zhang John H. 
Published: October 2018

AbstractBlood brain barrier (BBB) disruption is an important contributor to brain edema and neurological deficits following intracerebral hemorrhage (ICH). Macrophage stimulating protein (MSP) is a hepatocyte growth factor‐like protein that mediates its functions via activating receptor tyrosine kinase recepteur d'origine nantais (RON). Grb2‐associated binder 1 (GAB1) is a docking protein that mediates downstream receptor signal transduction pathways. This study aimed to evaluate the role of MSP and RON activated signaling pathway in preserving BBB integrity after collagenase‐induced ICH. ICH mice received recombinant human MSP (rhMSP) or rhMSP combined with siRNA knockdown of RON or GAB1. rhMSP was administered by intranasal route 1 h after ICH. Brain edema, neurobehavior, BBB tight junction protein expression, and BBB permeability were evaluated. The expression of endogenous MSP and p‐RON was decreased after ICH. Exogenous rhMSP administration reduced brain edema, neurological deficits, BBB permeability, and increased the expression of tight junction proteins in ICH mice. rhMSP administration increased the expression of p‐RON, p‐GAB1, p‐Src, nuclear β‐catenin, and tight junction proteins after ICH. These effects were reversed with RON and GAB1 siRNA. We conclude that MSP activation of RON preserved BBB integrity via GAB‐1/Src/β‐catenin pathway, thereby reducing brain edema and neurological deficits after ICH in mice.
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Pediatric Congenital Cerebrovascular Anomalies
Authors: Goyal Pradeep , Mangla Rajiv , Gupta Sonali , Malhotra Ajay , Almast Jeevak , Sapire Joshua , Kolar Balasubramanya 
Published: October 2018

ABSTRACTCongenital cerebrovascular anomalies in the pediatric age group are myriad with diverse etiologies. The purpose of this paper is to provide an imaging overview of congenital vascular malformations and vascular tumors, as these conditions are varied and the characteristic vascular abnormality may even suggest the underlying systemic condition in helping to guide further management. For example, the identification of an arterial anomaly such as agenesis/hypoplasia/duplication may warrant further evaluation for an associated syndrome. Recognition of other pertinent findings, such as persistent carotid‐vertebrobasilar anastomoses for instance, would be particularly important for the planning of potential embolization/coiling of associated vascular malformation and/or aneurysm. Awareness of congenital dural sinus anomalies, including hypoplasia, aplasia, and or duplication, prevents the incorrect or overdiagnosis of sinus thrombosis. Moreover, multiple developmental venous anomalies in a patient may require further investigation for its familial association. In a similar context, there may be familial association with multiple cavernous malformations and children with central nervous system vascular malformations may have an association with other vascular conditions, eg, hereditary hemorrhagic telangiectasia, etc. An accurate description of vascular lesions is critical for understanding the natural history of the disease process and ultimately for guiding treatment. An important example of this includes Sturge‐Weber syndrome, which is often incorrectly viewed as an arteriovenous malformation, but actually a type of venous malformation. Another example which is important to recognize includes the differentiation between an infantile hemangioma and a vascular malformation, particularly as the course of the pathology and the treatment is so different between the two.
Spanish Validation of the Emotion Regulation Questionnaire for Children and Adolescents (ERQ‐CA): Introducing the ERQ‐SpA
Authors: Martín‐Albo José , Valdivia‐Salas Sonsoles , Lombas Andrés Sebastián , Jiménez Teresa I. 
Published: October 2018

Research on emotion regulation is now extensive and shows the benefits of the adaptive management of emotions for social functioning and psychological well‐being. Our purpose was to test the psychometric properties of the Emotion Regulation Questionnaire for Children and Adolescents with a sample of nonclinical Spanish adolescents. A total of 462 secondary education students (223 girls, mean age = 13.89 years, SD = 1.38) participated. The instrument proved to be two‐factor and gender‐invariant. Results revealed the temporal stability of both emotion regulation strategies, while the predictive validity study revealed that depressive symptoms were negatively related to cognitive reappraisal, and positively related to expressive suppression. Our findings support the use of the ERQ‐SpA in Spanish adolescents.
Hedonic analysis and time‐varying capitalization: An application using school quality
Authors: Towe Charles A. , Tra Constant I. 
Published: October 2018

AbstractThis paper investigates the dynamics of school quality capitalization during the boom–bust cycle of the housing market. We find that the housing downturn led to a sharp increase in capitalization for high‐quality schools, whereas the boom and recovery periods saw a decline in valuation for top schools. Hence, the capitalization of school quality exhibits a strong countercyclical trend with the overall housing market. We test whether our findings are driven by households “trading down” from private schools during downturns or the fact that the housing supply responds asymmetrically during the boom and bust, but we find little support for these propositions.
Enhanced Second Language Vocabulary Learning Through Phonological Specificity Training in Adolescents
Authors: van de Ven Marco , Segers Eliane , Verhoeven Ludo 
Published: October 2018

This longitudinal randomized trial study investigated the effects of phonological specificity training on second language (L2) vocabulary learning. Eighty‐six Dutch secondary‐school students participated in one of two experimental conditions or in an animacy judgment (active control) condition. Participants in the phonological specificity training (with phonological manipulation) and the picture selection (without phonological manipulation) experimental conditions had to select the corresponding picture from among competitors after hearing a word. Phonological specificity training resulted in increased learning (measured through word translation) compared to the control condition on the posttest whereas picture selection produced increased learning only for participants with larger initial vocabulary sizes. Both experimental conditions showed increased learning for participants with larger vocabulary sizes on the retention test. Compared to picture selection, phonological specificity training showed more learning immediately after intervention for words with nonnative contrasts. Results suggest that phonological features can augment (meaning‐focused) L2 vocabulary learning interventions.Open PracticesThis article has been awarded an Open Materials badge. All materials are publicly accessible via the IRIS Repository at https://www.iris-database.org. Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/vyxz/wiki.
Harbor seal pup dispersal and individual morphology, hematology, and contaminant factors affecting survival
Authors: Greig Denise J. , Gulland Frances M. D. , Harvey James T. , Lonergan Mike , Hall Ailsa J. 
Published: October 2018

AbstractUnderstanding the factors affecting individual harbor seal (Phoca vitulina) survival is essential for determining population level health risks. We estimated postweaning dispersal, and modeled the effects of morphology, hematology, and blubber contaminants on the survival of recently weaned harbor seal pups using a mark recapture framework. We deployed satellite transmitters on apparently healthy pups captured in San Francisco Bay (SFB, n = 19) and Tomales Bay (TB, n = 7), and pups released after rehabilitation that stranded along the central California coast preweaning (n = 21). Dispersal distances were further than previously reported for harbor seal pups (maximum = 802 km) which has implications for understanding risks to this vulnerable age class. We found differences in body condition, serum immunoglobulin and thyroxine (T4) concentrations, white blood cell count, and blubber organohalogen contamination (OH) among the three groups. Overall, increased T4, decreased OH, and increased mass were associated with greater survival probabilities; whereas, among stranded seals, greater mass gain, shorter time in rehabilitation, and admission to rehabilitation earlier in the season were associated with greater survival probabilities. Attention to these latter factors may improve the success of rehabilitation efforts. For wild pups, reduction of legacy contaminants and direct causes of mortality, such as ship strike, may enhance pup survival.
The innovation and diffusion of “trap‐feeding,” a novel humpback whale foraging strategy
Authors: McMillan Christie J. , Towers Jared R. , Hildering Jackie 
Published: October 2018

AbstractThe innovation and diffusion of novel foraging strategies within a population can increase the capacity of individuals to respond to shifts in prey abundance and distribution. Since 2011, some humpback whales (Megaptera novaeangliae) off northeastern Vancouver Island (NEVI), Canada, have been documented using a new feeding strategy called “trap‐feeding.” We provide the first description of this foraging innovation and explore the ecological and social variables associated with its diffusion using sightings data, video analysis, and logistic regression modeling. The number of humpback whales confirmed to trap‐feed off NEVI increased from two in 2011 to 16 in 2015. Neither the locations of trap‐feeding sessions nor prey species consumed differed from those documented during lunge‐feeding. However, preliminary results indicate that the schools of fish consumed when individuals trap‐fed were smaller and more diffuse than those consumed when whales lunge‐fed. Top‐ranked models predicting whether an individual would be observed exhibiting trap‐feeding behavior included the following parameters: average number of days per year that the individual was seen off NEVI and proportion of the individual's associations that were with other trap‐feeders. These results suggest that trap‐feeding may be a culturally transmitted foraging innovation that provides an energetically efficient method of feeding on small, diffuse prey patches.
Come on feel the noise: Ecological foundations in stochastic bioeconomic models
Authors: Sims Charles , Horan Richard D. , Meadows Benjamin 
Published: October 2018

AbstractBioeconomic approaches to resource management treat renewable resources as naturally reproducing assets, or natural capital, whose conservation generates an economic rate of return. Stochasticity in resource growth produces stochasticity in these returns, affecting both the economic efficiency and ecological sustainability of resource use. Traditional bioeconomic models find that the rate of return to conservation is increased by a risk premium that may lower conservation incentives for more random populations. But these prescriptions depend on how the stochasticity of resource growth is modeled. Whereas the ecological literature adopts stochastic processes based on ecological considerations, bioeconomic analyses generally rely on ad hoc specifications chosen for convenience. Using analytical and numerical applications to the efficient management of fisheries and forests, we find that risk premium calculations based on traditional bioeconomic approaches versus ecological approaches may differ both quantitatively and qualitatively so that not all sources of ecological stochasticity imply conservation is risky.Recommendations for Resource ManagersBioeconomic approaches to resource management link economic and ecological models to evaluate economic–ecological tradeoffs arising from different management choices. The bioeconomic literature has focused very little on the implications of stochastic resource growth, and the specification of stochasticity in these analyses is generally ad hoc and not ecologically justifiable. We bridge this gap by adopting specifications promoted by ecologists and demonstrate as follows:Not all sources of ecological stochasticity imply conservation is risky. This result contrasts with traditional bioeconomic findings, driven by ad hoc modeling assumptions, that natural capital is always a risky investment.Whether a particular source of stochasticity implies conservation is risky may be state dependent.Even when models based on ecological notions of stochasticity do imply that conservation is risky, the magnitude of these risks and the ability of conservation efforts to manage risks may differ greatly from traditional bioeconomic specifications.
Understanding human enhancement technologies through critical phenomenology
Authors: Pariseau‐Legault Pierre , Holmes Dave , Murray Stuart J. 
Published: October 2018

AbstractHuman enhancement technologies raise serious ethical questions about health practices no longer content simply to treat disease, but which now also propose to “optimize” human beings’ physical, cognitive and psychological abilities. These technologies call for a reassessment of our relationship to health, the human body and the body's organic, identity and social functions. In nursing, such considerations are in their infancy. In this paper, we argue for the relevance of critical phenomenology as a way to better understand the ethical issues related to human enhancement technologies (HET). In so doing, we seek to problematize HET and assess their influence on the future development of nursing science and practice. It is difficult to anticipate the concrete effects of HET, we suggest, because these practices reconfigure the meaning of normativity and disorient our conventional ethical landscape. In this context, we argue that the later work of Martin Heidegger and Michel Foucault invites a critical perspective into how techno‐scientific discourses modify our relationship to care, to health and to our own social and corporeal identities. Despite the traditional philosophical opposition between phenomenology and critical theory, we maintain that a hybrid critical phenomenological approach opens new ways to assess the integration of technology and practice. Our analysis understands HET as a process of “hybridization” between technological objects and human subjects. Critical phenomenology thus effectively questions anthropocentric definitions of technology, challenges the dichotomy between curative treatment and enhancement and, finally, prompts valuable reflection on the implications of HET for nursing theory and practice.
Chromosome manipulations for progress of triticale (×Triticosecale) breeding
Authors: Kwiatek Michał T. , Nawracała Jerzy 
Published: October 2018

AbstractIn this review, we present the current state of knowledge and directions of future prebreeding studies of hexaploid triticale concerning chromosome manipulations. We specify the main goals for creating chromosome aberrations in this artificially generated crop, which are referred to as introgression of genes that are responsible for quality traits, biotic stresses resistance, and heterosis. We discuss the breeding methods, supported by cytomolecular analyses, which are based on development of chromosome aberrations induced by meiotic restitution, chromosome elimination, chromosome fragmentation or random fusion of chromatin fragments into chromosome structures. What is more, this kind of chromosome manipulations can be generated through induced cross‐hybridizations, which are alternatives to genome editing technologies, associated with the production of genetically modified organisms (GMOs). We also show the newest modifications and improvements in triticale breeding strategies, which involve recent achievements in cytogenetics and genomics. At last, we discuss how the new methods, such as gametocidal factor system or induced homoeologous recombination, can be exploited to accelerate the breeding considering particular end‐use properties of triticale.
CLE9 peptide‐induced stomatal closure is mediated by abscisic acid, hydrogen peroxide, and nitric oxide in Arabidopsis thaliana
Authors: Zhang Luosha , Shi Xiong , Zhang Yutao , Wang Jiajing , Yang Jingwei , Ishida Takashi , Jiang Wenqian , Han Xiangyu , Kang Jingke , Wang Xuening , Pan Lixia , Lv Shuo , Cao Bing , Zhang Yonghong , Wu Jinbin , Han Huibin , Hu Zhubing , Cui Langjun , Sawa Shinichiro , He Junmin , Wang Guodong 
Published: October 2018

AbstractCLE peptides have been implicated in various developmental processes of plants and mediate their responses to environmental stimuli. However, the biological relevance of most CLE genes remains to be functionally characterized. Here, we report that CLE9, which is expressed in stomata, acts as an essential regulator in the induction of stomatal closure. Exogenous application of CLE9 peptides or overexpression of CLE9 effectively led to stomatal closure and enhanced drought tolerance, whereas CLE9 loss‐of‐function mutants were sensitivity to drought stress. CLE9‐induced stomatal closure was impaired in abscisic acid (ABA)‐deficient mutants, indicating that ABA is required for CLE9‐medaited guard cell signalling. We further deciphered that two guard cell ABA‐signalling components, OST1 and SLAC1, were responsible for CLE9‐induced stomatal closure. MPK3 and MPK6 were activated by the CLE9 peptide, and CLE9 peptides failed to close stomata in mpk3 and mpk6 mutants. In addition, CLE9 peptides stimulated the induction of hydrogen peroxide (H2O2) and nitric oxide (NO) synthesis associated with stomatal closure, which was abolished in the NADPH oxidase‐deficient mutants or nitric reductase mutants, respectively. Collectively, our results reveal a novel ABA‐dependent function of CLE9 in the regulation of stomatal apertures, thereby suggesting a potential role of CLE9 in the stress acclimatization of plants.
Smells from the desert: Microbial volatiles that affect plant growth and development of native and non‐native plant species
Authors: Camarena‐Pozos David A. , Flores‐Núñez Víctor M. , López Mercedes G. , López‐Bucio José , Partida‐Martínez Laila P. 
Published: October 2018

AbstractThe plant microbiota can affect host fitness via the emission of microbial volatile organic compounds (mVOCs) that influence growth and development. However, evidence of these molecules and their effects in plants from arid ecosystems is limited.We screened the mVOCs produced by 40 core and representative members of the microbiome of agaves and cacti in their interaction with Arabidopsis thaliana and Nicotiana benthamiana. We used SPME‐GC‐MS to characterize the chemical diversity of mVOCs and tested the effects of selected compounds on growth and development of model and host plants.Our study revealed that approximately 90% of the bacterial strains promoted plant growth both in A. thaliana and N. benthamiana. Bacterial VOCs were mainly composed of esters, alcohols, and S‐containing compounds with 25% of them not previously characterized. Remarkably, ethyl isovalerate, isoamyl acetate, 3‐methyl‐1‐butanol, benzyl alcohol, 2‐phenylethyl alcohol, and 3‐(methylthio)‐1‐propanol, and some of their mixtures, displayed beneficial effects in A. thaliana and also improved growth and development of Agave tequilana and Agave salmiana in just 60 days.Volatiles produced by bacteria isolated from agaves and cacti are promising molecules for the sustainable production of crops in arid and semi‐arid regions.
Online cathodal transcranial direct current stimulation to the right homologue of Broca's area improves speech fluency in people who stutter
Authors: Yada Yasuto , Tomisato Shuta , Hashimoto Ryu‐ichiro 
Published: October 2018

AimPrevious functional imaging studies demonstrate that people who stutter (PWS) exhibit over‐ and under‐activation of Broca's and Wernicke's areas and their right hemisphere homologues when speaking. However, it is unclear whether this altered activation represents the neural cause of speech dysfluency or a secondary compensatory activation in PWS. To clarify the functional significance of the altered activation pattern in classic language areas and their right homologues, we examined whether the severity of stuttering was affected when the activation of these areas was modulated by brain stimulation.MethodsWhile PWS read passages aloud, we applied transcranial direct current stimulation (tDCS) using electrode montages that included an anodal or cathodal electrode placed over one of the language areas and its right hemisphere homologue, with the second electrode placed over the contralateral supraorbital region. Each participant underwent both anodal and cathodal tDCS sessions, each of which included a sham stimulation. Effects of stimulation polarity and electrode location on the frequency of stuttering were analyzed.ResultsWe observed a significant interaction between polarity and location on the frequency of stuttering. Follow‐up analyses revealed that a tDCS montage including the cathodal electrode over right Broca's area (RB) significantly reduced the frequency of stuttering.ConclusionThe results indicated that stuttering severity was ameliorated when overactivation in RB was reduced by tDCS. This observation further suggests that speech dysfluency in PWS may be caused either by functional alteration in RB or by abnormal activation in speech motor control areas that are connected with RB.
Biphotonic Ionization of DNA: From Model Studies to Cell
Authors: Cadet Jean , Wagner J. Richard , Angelov Dimitar 
Published: October 2018

AbstractOxidation reactions triggered by low‐intensity UV photons represent a minor contribution with respect to the overwhelming pyrimidine base dimerization in both isolated and cellular DNA. The situation is totally different when DNA is exposed to high‐intensity UVC radiation under conditions where biphotonic ionization of the four main purine and pyrimidine bases becomes predominant at the expense of singlet excitation processes. The present review article provides a critical survey of the main chemical reactions of the base radical cations thus generated by one‐electron oxidation of nucleic acids in model systems and cells. These include oxidation of the bases with the predominant formation of 8‐oxo‐7,8‐dihydroguanine as the result of preferential hole transfer to guanine bases that act as sinks in isolated and cellular DNA. In addition to hydration, other nucleophilic addition reactions involving the guanine radical cation give rise to intra‐ and interstrand cross‐links together with DNA–protein cross‐links. Information is provided on the utilization of high‐intensity UV laser pulses as molecular biology tools for studying DNA conformational features, nucleic acid–protein interactions and nucleic acid reactivity through DNA–protein cross‐links and DNA footprinting experiments.