bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matrix metalloproteinases in patients with resistant hypertension and type 2 diabetes mellitus: relation with renal blood ﬂow and kidney function
Authors: Falkovskaya A. Yu. , Mordovin V. F. , Pekarskiy S. E. , Ripp T. M. , Zyubanova I. V. , Sitkova E. S. , Lichikaki V. A. , Manukyan M. A. , Suslova T. E. , Gusakova A. M. , Ryabova T. R. 
Published: March 2019

Objective.To evaluate the plasma levels of metalloproteinases (MMP) and their inhibitor in patients with resistant hypertension (RHTN) and type 2 diabetes mellitus (DM2) and their relationship with renal blood ﬂow and kidney function.Design and methods.The study included 18 patients with RHTN and DM2 and 16 individuals with RHTN without DM, who underwent offce and 24-h ambulatory blood pressure measurements, renal Doppler ultrasound, and laboratory tests (daily albuminuria, estimated glomerular fltration rate calculated by CKD-EPI formula, HbА1c and basal glycaemia levels, MMP-9, MMP-2, tissue inhibitor of MMP type 1 (TIMP1), MMP/TIMP-1 ratios).Results.Patients with RHTN and DM2 and subjects with RHTN without DM were comparable by mean levels of metalloproteinases, TIMP-1, and their ratios. The frequency of increased MMP-9 level was similar in both groups (61 % for RHTN + DM2 group and 75 % for RHTN without DM, p > 0,05). In patients with RHTN and DM2 the increase in MMP-9 and a decrease in TIMP-1/MMP-9 ratio were associated with a reduction in renal resistive indices (MMP-9 and RI in the main renal arteries: right-sided R = –0,60, p = 0,009, left-sided R = –0,60, p = 0,008; in segmental arteries: R = –0,49, p = 0,038 on the right and R = –0,59, p = 0,012 on the left; for TIMP-1/MMP-9 and segmental arteries: R = 0,51, p = 0,028 on the right; and R = 0,46, p = 0,04 on the left). The eGFR and MMP-9 signifcantly correlated (R = 0,55, p = 0,023). Patients with increased albuminuria showed higher values of TIMP-1/MMP-2 ratio than patients with normal albuminuria (2,97 ± 0,82 и 1,58 ± 0,33 ng/mL, respectively, p = 0,03). There was a direct correlation between TIMP-1/MMP-2 ratio and basal glycaemia (R = 0,59, p = 0,018).Conclusions.Patients with RHTN and DM2 had comparable MMP levels and their inhibitor to those in patients with RHTN without DM, which may partly reﬂect that extracellular matrix formation is independent from carbohydrate disorders in RHTN. In patients with RHTN and DM2 an increase in MMP-9 and a decrease in TIMP-1/MMP-9 ratio may be adaptive, since it is accompanied by improved intrarenal blood ﬂow and renal fltration function. The increase in basal hyperglycemia is associated with the suppression of the proteolytic activity of MMP-2 related to the progression of albuminuria.
Evaluation of blood pressure using Korotkoff’s sounds in case of auscultatory gap
Authors: Tikhonenko V. M. , Pivovarov V. V. , Kormilitsyn A. Y. , Zaitsev G. К. 
Published: March 2019

Objective. To assess the clinical signifcance of auscultatory gap (AG) found by the 24-hour ambulatory blood pressure monitoring (ABPM) using the Korotkoff’s sounds (KS) and its potential causes.Design and methods. 24-hour ABPM was performed in 60 patients (mean age 51,3 years, range 22–85 years), including 24 women and 36 men. In 24 patients, hypertension was diagnosed. In total, 2333 blood pressure (BP) measurements without “noise contamination” were selected for subsequent analysis (38,9 measurements per patient; from 28 to 73 measurements). The simultaneous recording of electrocardiogram (ECG), brachial cuff pressure, and KS phonograms on the right hand, as well as continuous recording of non-invasive BP curve in the left fnger using the volume clamp technique were performed in 10 patients with AG.Results. Based on the 24-hour ABPM, AG was shown in 43 of 60 subjects (71,7%). The AG was found to be associated with a decreased amplitude of ﬂuctuations of the cuff pressure; upon its termination, the amplitude recovered. The above synchrony of changes in KS and amplitude of pressure ﬂuctuations was found in all 124 cases which demonstrated AG during BP measurement. We assume that AG is a true variation of BP rather than a feature of KS, as the ﬂuctuation amplitude depends on the ratio of BP and cuff pressure but does not depend on the KS phase. To test the hypothesis, the cuff pressure and KS were compared to the continuously monitored arterial pressure. When the systolic arterial pressure exceeded the cuff pressure, the KS appeared. Later on, the BP ﬂuctuations led to a decrease in systolic BP; the arterial pressure did not reach the cuff pressure and, therefore, KS were not recorded. Subsequent decrease in the cuff pressure led to re-appearance of KS.Conclusions. The auscultative gap phenomenon is associated with true (mostly respiratory) variations of systolic BP rather than with features of KS in individual patients. The initial and repetitive KS occur at certain systolic BP levels depensing on the BP respiratory ﬂuctuations and may indirectly indicate the amplitude of ﬂuctuations.
Malli käyttäjäkeskeisen suunnittelun johtamiseen julkisella sektorilla
Authors: Kautonen Heli 
Published: March 2019

TaM Heli Kautonen väitteli 22.2.2019 Aalto-yliopiston perustieteiden korkeakoulussa aiheesta "BAIST-viitemalli julkista arvoa tuottavaan digitaaliseen palvelun käyttäjäkeskeiseen suunnitteluun". Vastaväittäjänä toimi professori Netta Iivari (Oulun yliopisto), ja kustoksena professori Marko Nieminen (Aalto-yliopiston perustieteiden korkeakoulu). Tietotekniikan alaan kuuluva väitöskirja on julkaistu sarjassa Aalto university publication series: doctoral dissertations, ja se on luettavissa myös Aalto-yliopiston Aaltodoc-julkaisuarkistossa osoitteessa http://urn.fi/URN:ISBN:978-952-60-8374-2.
Lektiota on kevyesti toimitettu kirjallisessa muodossa julkaisemista varten.
Relationship between leg-length discrepancy and plantar fasciitis
Authors: Mansur Henrique , Carvalho Guilherme Gonçalves Feijó , Lima Thiago Coelho Paim , Gonçalves Cesar Barbosa , Durigan João Luiz Quagliotti , Castro Junior Isnar Moreira 
Published: March 2019

Objective: This study evaluated the relationship between leg-length discrepancy (LLD) and plantar fasciitis (PF). Methods: A cross-sectional study was performed that measured the length of the lower limbs via a scanometry of patients with PF. Other risk factors such as body mass index (BMI), foot posture, and the presence of a plantar heel spur on foot X-ray were also evaluated. Results: Of the 54 participating patients, 44.4% were male with a mean age of 50.38 (23-73 years), 81.5% had pain in one foot, and 53.7% had plantigrade feet. We observed LLD in 88.9% of the sample, with a mean discrepancy of 0.749 cm (SD +/-0.63); 46.3% of the painful feet presented with spurs on X-ray. Conclusions: Approximately 90% of the patients presented with LLD, and the shorter limb was the affected side in most cases. Level of Evidence II; Prognostic Studies.
Diversities
Authors: Mizusaki Jorge Mitsuo 
Published: March 2019

At a time when cultural diversity is being discussed all over the world, we can propose topics that represent our scientific and technical diversity, as well as our way of taking care of medical matters.
We are publishing in our edition 13.1 the results of an intense work composed of themes involving several aspects related to the foot and ankle, such as: soft tissue and bone diseases, trauma, and metabolic and cultural aspects related to diseases. This diversity of subjects demonstrates the extent of the professional activity that treats and cares for the patients in a global way. Certainly, this is a reflection of our professional work of assisting the population.
This concern with professional, technical and scientific development is the focus of our society - ABTPé, which does not measure efforts to offer the best conditions in order to train the orthopedic foot and ankle surgeon. The result of this work is being obtained and can be evaluated by several articles in this edition.
This diversity of ways of conducting the important aspects related to foot and ankle diseases can be evaluated through articles that have been selected by the reviewers, and which will greatly benefit our patients.
We believe that our interaction with professionals from other specialties determines new ways of acting and evaluating our results, which requires better adaptation and ethical posture for a healthy and progressive coexistence. The social and economic question already has reflexes in our perspective of proposing treatments.
The technological evolution must add new values ​​to the medical act, but it does not replace our action of taking care of the patient.
I invite you to appreciate the content of this edition composed of horizons to be revealed.
Have a great reading

Jorge Mitsuo MizusakiEditor-in-chief
ANALISIS EFEKTIVITAS DAN EFISIENSI PENGGUNAAN ANGGARAN BELANJA PADA KOMISI PEMILIHAN UMUM PERIODE 2011-2015 (STUDI KASUS PADA KOMISI PEMILIHAN UMUM KOTA PAYAKUMBUH)
Authors: Siska Adilla Juita , Afriyanto Nono 
Published: March 2019

Organisasi Sektor Publik dituntut untuk memperhatikan velue for money dalam menjalankan aktifitasnya. Tujuan yang dikehendaki masyarakat mencakup pertanggungjawaban mengenai pelaksanaan velue for money, yaitu ekonomis dalam pengadaan dan alokasi sumber daya, efisien dalam penggunaan sumber daya dalam arti penggunaannya diminimalkan dan hasilnya dimaksimalkan, serta efektif dalam arti mencapai tujuan dan sasaran.
Tujuan penelitian ini adalah untuk mengetahui Deskripsi Penganggaran dan menganalisis efektivitas dan efisiensi penggunaan anggaran belanja pada Komisi Pemilihan Umum Kota Payakumbuh. Analisis data yang digunakan analisis deskriptif dengan menggunakan rasio efektivitas dan efisiensi. Deskripsi Penganggran dilaksankan secara berjenjang dimulai dari tingkat Kabupaten/Kota, Provinsi dan Pusat, KPU Pusat Mempunyai kuasa penuh terhadap penambahan dan pengurangan anggaran belanja yang tertuang didalam DIPA Satuan Kerja (satker). Tingkat dan kriteria efektifitas penggunaan anggaran belanja pada Komisi Pemilihan Umum Kota Payakumbuh dari tahun 2011 s.d 2015 sangat bervariasi. Tingkat efektifitas tertinggi terjadi pada 2015 dan yang terendah terjadi pada 2012. Penggunaan anggaran belanja tahun 2011, 2015 dikategorikan efektif, tahun 2012, 2013 dan 2014 dikategorikan cukup efektif karena realisasi anggaran belanja memiliki perbedaan yang jauh dengan target anggaran belanja. Perbedaan ini terjadi karena ada beberapa kegiatan yang dianggarkan, tapi tidak dilaksanakan. Tetapi untuk kegiatan lain yang telah dianggarkan sudah efektif. KPU Kota Payakumbuh menilai ketika kegiatan yang direncankan/programkan sudah terealisasi dan sesuai dengan yang diharapkan, maka kegiatan tersebut dikatakan efektif. Pelaksanaan anggaran Belanja KPU Kota Payakumbuh Tahun 2011 s.d 2015, secara keseluruhan sudah diolah secara efisien. Pelaksanaan anggaran belanja tahun 2011 sampai 2015, dikategorikan sangat efisien hanya tahun 2013 dan 2014 dikategorikan tidak efisien dikarenakan pada tahun tersebut KPU Kota Payakumbuh tidak menganggarkan Anggaran Tahapan Pelaksanaan Pemilihan Legislatif dan Pemilihan Presiden dan Wakil Presiden.
PENGARUH PROFITABILITAS DAN LEVERAGE TERHADAP TANGGUNG JAWAB SOSIAL PERUSAHAAN (CORPORATE SOCIAL RESPONSIBILITY) PADA PT BANK SYARIAH BUKOPIN
Authors: Devy Tartila , Wulandari Indah Tri 
Published: March 2019

<p>Tujuan dari penelitian ini adalah untuk mengetahui sejauh mana pengaruh profitabilitas dan leverage di Bank Syariah Bukopin terhadap <em>Social Corporate Responsibility</em>. Penelitian ini dilatar belakangi alasan pentingnya suatu bank syariah untuk menampilkan dirinya lebih baik dibandingkan dengan perbankan konvensional. Gambaran baik buruknya suatu perbankan syariah dapat dikenali melalui kinerja baik yang tergambar dari tanggungjawab sosialnya maupun dari laporan keuangannya. Jika dilihat dari rasio keuangan yakni rasio profitabilitas (ROA) dan rasio <em>leverage (Debt to Equity)</em>, PT Bank Syariah Bukopin memiliki ROA dan <em>Debt to Equity</em> yang mengalami fluktuasi disamping memiliki berbagai bentuk kegiatan CSR tiap tahunnya.</p><p>Jenis penelitian ini merupakan penelitian deskriptif kuantitatif, dengan menggunakan analisis Regresi Analisis Berganda. Variabel dalam penelitian ini terdiri dari satu variabel dependen dan dua variabel independen. Variabel dependen atau variabel Y dalam penelitian ini adalah tanggung jawab sosial perusahaan (<em>Corporate Social Responsibility</em>), sedangkan variabel independen terdiri dari X1 yaitu profitabilitas dan X2 yaitu <em>leverage</em><em>.</em>Jenis data yang digunakan dalam penelitian ini adalah dengan menggunakan data sekunder. Data diambil dari laporan keuangan dan laporan pengungkapan tanggung jawab sosial perusahaan (<em>Corporate Social Responsibility</em>) pada PT Bank Syariah Bukopin.</p><p>Kesimpulannya adalah: 1) Profitabilitas (ROA) berpengaruh signifikan terhadap <em>Corporate Social Responsibility</em> (CSR) pada PT Bank Syariah Bukopin (Sig = 0.001 &lt; α = 0.05). 2) <em>Leverage (Debt to Equity</em>) berpengaruh signifikan terhadap <em>Corporate Social Responsibility</em> (CSR) pada PT Bank Syariah Bukopin (Sig = 0.000 &lt; α = 0.05). 3)Secara bersama-sama Profitabilitas (ROA) dan <em>Leverage (Debt to Equity) </em>tidak berpengaruh signifikan terhadap<em> Corporate Social Responsibility</em> (CSR) pada PT Bank Syariah Bukopin (Sig = 0.180 &gt; α = 0.05).</p>
Assessment of occupational risk caused by noise exposure in workers at metallurgical plant subunits under modernization
Authors: Bazarova Ye. L. , Fedoruk A. A. , Roslaya N. A. , Osherov I. S. , Babenko A. G. 
Published: March 2019

Introduction. Noise is a common occupational hazard in metallurgic production. Objective. To evaluate occupational risk caused by exposure to noise in 18 occupational groups in subunits under modernization in an enterprise producing titanium alloys, using methodology of N.F. Izmerov Occupational Medicine Research Institute. Materials and methods. A priori risk evaluation by noise measurements was performed according to criteria of Manuals R 2.2.2006–05, R 2.2.1766–03 and hygienic models, a posteriori one — by analysis of occupational morbidity over 30 years, transitory disablement morbidity and chronic diseases prevalence according to medical examinations data over 5 years. Total of 58758 sick-leave certifi cates was analyzed. Comparison covered morbidity in individuals exposed to noise (3501 individuals) and non-exposed individuals (9138 ones). Results. Findings are that a risk level by hygienic criteria in the studied occupations was assigned to low to high category (work conditions classes 3.1–3.3), by occupational morbidity criterion — from low to high (index of occupational diseases from 0 to 0.25). Occupational neurosensory deafness was registered in blacksmiths, turners, vertical lathe operators. Noise appeared to be a trigger for diseases of ears, eyes, skin, locomotory system, nervous system, urinary tract, respiratory system, for mental disorders, increased blood pressure, hyperglycemia, leukocytosis, with 1.1–1.7 times reliably increased their risk in general over the production, and up to 3.7 times in certain occupations (p<0.05). Prevalence of the health disorders appeared to increase with growing noise levels. Conclusions. Industrial modernization is associated with decrease of occupational morbidity caused by exposure to noise to single cases and increase of age and length of service at noise conditions to diagnosis. Considerable health improvement was seen in blacksmiths, aft er hammer equipment was changed to the press one, in lathe operators — aft er lathe changed to processing centers with numerical control.
Macro nutrient status of Sundarbans forest soils in Southern region of Bangladesh
Authors: Khan MZ , Amin MS 
Published: March 2019

An attempt has been made to evaluate the condition of soil of the Sundarban mangrove forest of Bangladesh by applying standard method. Soil pH was varied from 6.63 to 7.87. Organic carbon of soil was found 4.06, 4.79, 5.59, 9.38 and 9.80 (gKg-1) at Kotka, Kochikhali, Hironpoint, Harbaria, and Dublarchar, respectively. The electrical conductivity of soil was varied from 14.39, to 42.89 (dSm-1) in the study areas.The cation exchange capacity in the soils was varied from 22.32 to 27.2 Cmolckg-1 in the study area. The average percentages of total nitrogen content in the soil were varied from 0.04 to 0.08%. The soils of Oligohaline zone of Sundarban mangrove forest are rich in water soluble and exchangeable magnesium followed by calcium and the potassium. The percentages of silt and clay were higher than sand in all study areas. Dissolved chloride in the soil was found 7010, 4186,11750 and 16389 (μg g-1) at Hironpoint, Harbaria, Dublarchar and Kotka respectively.
Bangladesh J. Sci. Ind. Res.54(1), 67-72, 2019
PENGARUH INFRA RED, MASSAGE DAN TERAPI LATIHAN PADA CONGENITAL MUSCULAR TORTICOLLIS
Authors: Amin Akhmad Alfajri , Amanati Suci , Nahdiyah Neneng 
Published: March 2019

Latar Belakang: Data Statistik di Indonesia menunjukkan 1 dari 300 bayi lahir dengan tortikolis otot bawaan. Kelainan ini lebih sering terjadi pada anak pertama. Tortikolis terjadi pada 0,4 % dari seluruh kelahiran. Sedangkan untuk noncongenital muscular torticollis, rata-rata terjadi pada usia 40 tahun. Perempuan lebih sering terkena dengan perbadingan 2 : 1 dibandingkan lakilaki (Putri, 2010). Penelitian ini dilakukan di RSUD Kajen di Kota Pekalongan pada bulan November 2017 dengan mengambil sampel sebanyak 8 orang partisipan. Metode penelitian menggunakan pretest-posttest dengan quasi eksperimen. Tindakan fisioterapi yang diberikan pada kasus ini adalah dengan infra red, massage dan terapi latihan. Tujuan: Untuk mengetahui pengaruh fisioterapi dengan modalitas Infra Red, Massage, dan Terapi Latihan pada kasus Congenital Muscular Torticollis.
Hasil: Berdasarkan hasil uji hipotesis untuk panjang otot sternocleidomastoideus untuk posisi netral didapatkan terjadi perubahan signifikan pada partisipan antara sebelum terapi dibandingkan setelah terapi ditunjukkan dengan nilai sig (2tailed) sebesar 0,005 yang berada pada batas kritis <0,05 yang berarti Ho ditolak dan Ha diterima dan untuk nilai panjang otot sternocleidomastoideusuntuk posisi terulur didapatkan hasil 0,001 yang bermakna <0,05, yang berarti Ho ditolak dan Ha diterima, yaitu terjadi perubahan yang signifikan antara sebelum dengan sesudah terapi.
Kesimpulan: Berdasarkan hasil penelitian kali ini menunjukkan bahwa penggunaan Infra red, Massage dan terapi latihan berupa relaxed passive movement dan stretching mampu meningkatkan panjang dan elastisistas otot sternocleidomastoideus secara signifikan, dengan peningkatan panjang otot saat netral menunjukkan spasme pada otot tersebut berkurang.
PENGARUH TERAPI LATIHAN PADA POST TOTAL HIP REPLACEMENT ET CAUSA NEGLECTED CLOSE FRACTURE NECK FEMUR
Authors: Amin Akhmad Alfajri , Amanati Suci , Siswanto Tedi 
Published: March 2019

Latar Belakang : . Berdasarkan data dari Dinas Kesehatan Provinsi Jawa Tengah tahun 2007 didapatkan sekitar 2.700 orang mengalami insiden fraktur, 56% penderita mengalami kecacatan fisik, 24% mengalami kematian, 15% mengalami kesembuhan dan 5% mengalami gangguan psikologis atau depresi terhadap adanya kejadian fraktur. Menurut data dari Sistem Informasi Rumah Sakit (SIRS) 2010, kasus patah tulang mengalami peningkatan setiap tahun sejak 2007. pada 2007 ada 22.815 insiden patah tulang, pada 2008 menjadi 36.947, 2009 jadi 42.280 dan pada 2010 ada 43.003 kasus. Penelitian ini dilakukan di Rumah Sakit dr. Loekmono Hadi Kudus dengan mengambil sampel sebanyak 8 orang partisipan. Penelitian ini dilakukan pada bulan Agustus 2017 menggunakan metode pretest-posttest dengan quasi eksperiman.
Tujuan : untuk mengetahui pengaruh terapi latihan pada kasus Post Total Hip Replacement et causa Neglected Fracture Neck Femur dalam menurunkan nyeri serta menjaga kekuatan Otot dan LGS, serta meningkatkan kemampuan Fungsional Aktifitas pasien
Hasil : Pada penelitian ini mendapatkan hasil berupa terjadi perubahan yaitu penurunan derajat nyeri yang signifikan antara sebelum dengan sesudah terapi ditunjukkan dengan nilai sig (2-tailed) < 0,05, sedangkan untuk skor FADI terjadi perubahan yaitu peningkatan kemampuan aktivitas fungsional kaki yang signifikan antara sebelum dengan sesudah terapi ditunjukkan dengan nilai sig (2-tailed) < 0,05.
Kesimpulan : Terapi Latihan dengan teknik Ankle Pumps, AAROM exercise, AROM exercise,Muscle Setting, Core Exercise, serta transfer dan ambulasi pada kasus total hip replacementefektif dalam menurunkan nyeri, dan peningkatan kemampuan fungsionalj aktifitas kakipartisipan.
QSAR and molecular docking studies on 4-quinoline carboxylic acid derivatives as inhibition of vesicular stomatitis virus replication
Authors: Hajalsiddig Tawassl Tajelsir Hassan , Saeed Ahmed Elsadig Mohammed 
Published: March 2019

The current study describes the development of in silico models based on quantitative structure-activity relationship (QSAR) analysis has been performed on 4-quinoline carboxylic acid derivatives as inhibition capacity of vesicular stomatitis virus replication in Madin Darby canine kidney epithelial cells. A highly descriptive and predictive QSAR model was obtained through the calculation of alignment-independent descriptors using MOE 2009.10 software. For a training set of 20 compounds, the partial least squares analyses result in a model which displays a squared correlation coefficient (r2) of 0.913. Validation of this model was performed using leave-one-out (q2) of 0.842. This model gives (r2pre) of 0.889 for a test set of five compounds. Docking studies were performed for 25 compounds to investigate the mode of interaction between 4-quinoline carboxylic acid derivatives and the active site of the human dihydroorotate dehydrogenase.
Cytotoxicity Activity and Phytochemical Screening of Anthocleista djalonensis Root Extracts against Cancer Cells
Authors: Okoro Ijeoma Solomon , Tor-Anyiin Terrumum Amom , Igoli John Ogbaji , Khan Muluh Emmanuel 
Published: March 2019

Aim: Several medicinal uses have been reported for Anthocleista djalonensis and many types of pure compounds have been isolated. However, the anti-cancer activity of this plant has not been proven. The aim of this study was to screen for the phytochemicals present in the rootn-hexane, ethyl acetate, and acetone extracts of Anthocleista djalonensis, and to evaluate its anticancer potential against human cervix adenocarcinoma cells (HeLa cells) in vitro.
Place and Duration of Study: The study was carried out in Department of Organic Chemistry, Rhodes University, Grahamstown, South Africa. The duration period was between March and July, 2016.
Methodology: Extracts were prepared by soaking the root powder in the respective solvents with continuous stirring; The extracts were filtered and evaporated to remove the solvents. The extracts were then screened for phytocompounds by preliminary screening methods. Anti-cancer potential was carried out by a Resazurin assay and CC50 values were determined.
Results: The extracts showed the presence of carbohydrates, glucoside, alkaloids, flavonoids, terpenoids, tannins, saponins, sterols. All extracts demonstrated moderate cytotoxicity against HeLa cells.
Conclusion: The hexane, ethyl acetate and acetone extracts showed anticancer property. The roots extracts of Anthocleista djalonesis were thus found to possess potential anticancer activities.