bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use and Patient-Reported Outcomes of Clinical Multigene Panel Testing for Cancer Susceptibility in the Multicenter Communication of Genetic Test Results by Telephone Study
Authors: Hall Michael J. , Patrick-Miller Linda J. , Egleston Brian L. , Domchek Susan M. , Daly Mary B. , Ganschow Pamela , Grana Generosa , Olopade Olufunmilayo I. , Fetzer Dominique , Brandt Amanda , Chambers Rachelle , Clark Dana F. , Forman Andrea , Gaber Rikki , Gulden Cassandra , Horte Janice , Long Jessica M. , Lucas Terra , Madaan Shreshtha , Mattie Kristin , McKenna Danielle , Montgomery Susan , Nielsen Sarah , Powers Jacquelyn , Rainey Kim , Rybak Christina , Savage Michelle , Seelaus Christina , Stoll Jessica , Stopfer Jill E. , Yao Xinxin (Shirley) , Bradbury Angela R. 
Published: December 2018

Purpose Multigene panels (MGPs) are increasingly being used despite questions regarding their clinical utility and no standard approach to genetic counseling. How frequently genetic providers use MGP testing and how patient-reported outcomes (PROs) differ from targeted testing (eg, BRCA1/2 only) are unknown. Methods We evaluated use of MGP testing and PROs in participants undergoing cancer genetic testing in the multicenter Communication of Genetic Test Results by Telephone study (ClinicalTrials.gov identifier: NCT01736345), a randomized study of telephone versus in-person disclosure of genetic test results. PROs included genetic knowledge, general and state anxiety, depression, cancer-specific distress, uncertainty, and satisfaction. Genetic providers offered targeted or MGP testing based on clinical assessment. Results Since the inclusion of MGP testing in 2014, 395 patients (66%) were offered MGP testing. MGP testing increased over time from 57% in 2014 to 66% in 2015 ( P = .02) and varied by site (46% to 78%; P < .01). Being offered MGP testing was significantly associated with not having Ashkenazi Jewish ancestry, having a history of cancer, not having a mutation in the family, not having made a treatment decision, and study site. After demographic adjustment, patients offered MGP testing had lower general anxiety ( P = .04), state anxiety ( P = .03), depression ( P = .04), and uncertainty ( P = .05) pre-disclosure compared with patients offered targeted testing. State anxiety ( P = .05) and cancer-specific distress ( P = .05) were lower at disclosure in the MGP group. There was a greater increase in change in uncertainty ( P = .04) among patients who underwent MGP testing. Conclusion MGP testing was more frequently offered to patients with lower anxiety, depression, and uncertainty and was associated with favorable outcomes, with the exception of a greater increase in uncertainty compared with patients who had targeted testing. Addressing uncertainty may be important as MGP testing is increasingly adopted.
Boa administração: um direito fundamental a ser efetivado em prol de uma gestão pública eficiente
Authors: Ismail Filho Salomão 
Published: December 2018

Good administration: fundamental right to be implemented in favor of efficient public management O direito administrativo moderno encontra-se intrinsecamente relacionado com o direito constitucional. Uma consequência de tal relação é o direito fundamental a uma boa administração. O conceito de boa governança, de caráter mais amplo e multidisciplinar, e o princípio da eficiência auxiliam na definição daquilo que seja uma boa administração no serviço público. É dever do gestor público/decisor político atender aos objetivos fundamentais da Constituição por meio de uma administração que concilie os custos orçamentários com os interesses e necessidades do administrado, ou seja, a pessoa humana, razão de ser do Estado. Modern administrative law is intrinsically related to constitutional law. One consequence would be the so-called fundamental right to good administration. The concept of good governance, broader and multidisciplinary, and the principle of efficiency help in the definition of what good administration is in the public service. The public and political manager has the duty to comply the fundamental objectives of Constitution through a management that reconciles the budget costs with interests and needs of the administered, that is, the human person, reason for existence of the State.
Strategi Komunikasi Publik Dalam Membangun Pemahaman Mahasiswa Terhadap Penerapan PTNBH
Authors: Zubair Feliza , Dewi Retasari , Kadarisman Ade 
Published: December 2018

Penelitian ini bertujuan untuk menganalisis strategi komunikasi publik yang dilakukan oleh Humas Institut Pertanian Bogor (IPB) dalam membangun pemahaman mahasiswa IPB terhadap penerapan PTNBH. Metode yang digunakan adalah kualitatif dengan pendekatan studi kasus. Wawancara mendalam dilakukan kepada Kabid Humas IPB dan Ketua Bem IPB, observasi dan studi pustaka .Teori yang digunakan adalah Kontruksi Atas Realitas, teori Stakeholder, teori Relationship Management dan konsep Komunikasi Publik. Hasil penelitian menunjukan bahwa pihak IPB mengkonstruksi esensi dari PTNBH yaitu otonomi, keleluasaan dalam penyelenggaraan rumah tangganya untuk menghasilkan pendidikan yang bermutu, ke dalam program-program yang dapat mendukung kemajuan mahasiswa. IPB dapat membangun hubungan menejerial yang alamiah dengan mahasiswa. Penelitian ini menunjukan bahwa strategi komunikasi publik yang dilakukan lembaga dapat membentuk kesepahaman dalam upaya menjaga relasi yang saling menguntungkan antara pengelola atau menejemen IPB/PTNBH dengan mahasiswa. Kata kunci: PTNBH, Strategi, Komunikasi publik, Otonomi The purpose of the research is to analyse the strategy of public communication implemented by Institut Pertanian Bogor (IPB) in developing comprehension of its students towards PTNBH implementation. Method used is qualitative with case study approach. Deep interview is done with Public Relations Head of IPB and Head of BEM (Badan Eksekutif Mahasiswa or Students Executive Board). In addition, this research involves observation and literature study. Theories used in this research are social construct of reality, stakeholder theory, relationship management, and public communication. Result shows that IPB has constructed the PTNBH’s essence of autonomy, freedom in managing its own administration of high quality education, programs in supporting students’ activities. IPB has the capabilities of developing a natural managerial connection with its students. The result also shows that public communication strategy implemented by institution would be able to create understanding and beneficial relationship between administrator/management of IPB and its students. Keywords: PTNBH, Strategy, Public communication, Autonomy.
Proses Komunikasi Dalam Sosialisasi Pilgub Sumatera Barat Tahun 2015
Authors: Mivadila Melisa , Chatra Emeraldy , Ariany Ria 
Published: December 2018

Penelitian ini dilator belakangi oleh pelaksanaan komunikasi KPU Sumatera Barat dalam sosialisasi Pilgub Sumatera Barat Tahun 2015 yang tidak mencapai target partisipasi pemilih sebesar 77,5 %. Penelitian ini dilakukan untuk mendeskripsikan dan menganalisis proses penyusunan, penyampaian serta penerimaan pesan sosialisasi, menemukan hambatan dan mengusulkan model proses komunikasi dalam sosialisasi. Penelitian ini menggunakan metode kualitatif dan dianalisis menggunakan model Boove dan Thil serta glamour theory. Hasil penelitian menunjukkan bahwa pelaksanaan komunikasi dalam sosialisasi belum maksimal dan pesan tidak tersebar merata diterima khalayak. Proses komunikasi dalam Pilgub Sumbar 2015 terdiri dari 8 (delapan) tahap. Hambatan yang ditemukan selama proses komunikasi yakni hambatan dalam proses, semantik, fisik dan psikologis. Hambatan lain yang ditemukan yaitu keterlambatan regulasi dan perencanaan yang tidak maksimal. Model proses komunikasi yang ditambahkan dalam tahapan komunikasi KPU Sumbar adalah tahap evaluasi. Saran dalam penelitian ini yaitu KPU Provinsi Sumbar perlu membuat perencanaan dengan baik, menggandeng relawan demokrasi yang dibekali dengan informasi pemilihan yang lengkap serta evaluasi sebaiknya dilakukan dalam setiap proses komunikasi. Kata Kunci: Proses Komunikasi, Sosialisasi. Tatap Muka. This research motivate by the implementation of KPU West Sumatra communication in the 2015 West Sumatra Pilgub socialization which did not reach the voter participation target of 77,5%. The research objective are to describe and analyze arrangement process, delivery and acceptance the socialization message, found obstacles and model of communication process in socialization. This research used a qualitative metho, analyze by Boove and Thil Model with the glamour theory. The research found that communication activities in socialization not maximal yet because the message not distribute broadly and accepted by public. The communication process on the 2015 West Sumatera Governor and Vice Governor Election consist of 8 (eight) phase. There are some obstacles found within communication process; obstacles in the process, semantic, physical and psychological. The others are delays in regulation and improper planning. Evaluation phase is model of communication process which is added on communication phase of West Sumatera Election Commission. The research propose that West Sumatera Election Commission have to plan qualified arrangement, cooperate with democratic volunteers which are provided with proper electoral information, then the evaluation should be performed in every process of communication. Keywords: Communication Process, Socialization, Face to face
Exploration of University Faculty Perceptions and Experiences of Service-Learning as Engaged Scholarship of Teaching and Learning
Authors: Arellano Irene , Jones Stephanie J. 
Published: December 2018

The purpose of this qualitative instrumental case study was to explore how faculty at a private research university utilize the service-learning pedagogy to advance their scholarship of teaching and learning. Of specific interest was what influences them to utilize the service-learning pedagogy in their scholarship of teaching and learning, and how they perceive that utilizing the service-learning pedagogy affects student learning. Boyer’s work on the scholarship of teaching and learning framed the study. The findings of this study are that the experiential components of the service-learning pedagogy are effective in connecting students to real-world problems. As part of the curriculum it engages students in deeper learning and its use changes students’ perspectives about the importance of community involvement, establishing a community consciousness to those students involved. The study supports that the service-learning pedagogy is important to higher education faculty and has led to supporting their scholarship of teaching and learning.
Drawing Video Game Mental Maps: From Emotional Games to Emotions of Play
Authors: Ter Minassian Hovig 
Published: December 2018

By exploring emotions at play in video game experiences, we sought to analyze how people interact with digital spaces in everyday life. Taking a somewhat different view than much of the literature in the field of video game studies, we examined emotions that were created from users’ experience of games, rather than focusing on game design and gameplay. To that end, we based our analysis on 38 video game mental maps drawn by 26 people. We successively analyzed the topic, the structure, and the experiential and emotional meaning of each of the mental maps. Thus, we explored the diversity of emotions that participants linked to video games, and examined the mental maps in relation to what the respondents said about how and why they chose to draw a particular video game. Our work shows the importance of looking beyond the analysis of affects and gameplay, and of examining the emotions produced by the video game experience, along with what they can tell us about the role of games in individual and collective spatial experiences and sociability. Everything doesn’t happen on the screen, and what is lived within the game also depends on what is lived in the physical space of the player. In other words, video games aren’t emotional in themselves, but there are significant video game experiences that contribute to the structuration of individuals.
Preanalytical considerations in therapeutic drug monitoring of immunosuppressants with dried blood spots
Authors: Klak Adrian , Pauwels Steven , Vermeersch Pieter 
Published: December 2018

Abstract

Background
Dried blood spots (DBSs) could allow patients to prepare their own samples at home and send them to the laboratory for therapeutic drug monitoring (TDM) of immunosuppressants. The purpose of this review is to provide an overview of the current knowledge about the impact of DBS-related preanalytical factors on TDM of tacrolimus, sirolimus and everolimus.

Content
Blood spot volume, blood spot inhomogeneity, stability of analytes in DBS and hematocrit (Hct) effects are considered important DBS-related preanalytical factors. In addition, the influence of drying time has recently been identified as a noteworthy preanalytical factor. Tacrolimus is not significantly influenced by these factors. Sirolimus and everolimus are more prone to heat degradation and exhibited variations in recovery which were dependent on Hct and drying time.

Summary and outlook
DBS-related preanalytical factors can have a significant impact on TDM for immunosuppressants. Tacrolimus is not significantly influenced by the studied preanalytical factors and is a viable candidate for DBS sampling. For sirolimus and everolimus more validation of preanalytical factors is needed. In particular, drying conditions need to be examined further, as current protocols may mask Hct-dependent effects on recovery. Further validation is also necessary for home-based self-sampling of immunosuppressants as the sampling quality is variable.
The Application and Effectiveness of Yoga in Prevention and Rehabilitation of Sport Injuries in Athletes Participating in Competitive Sport
Authors: Ravi Sunitha 
Published: December 2018

Abstract
The purpose of the study is to review literature for scientific studies about application and effectiveness of yoga in rehabilitation & prevention of sports injuries in athletes participating in competitive sports. The author conducted a comprehensive search of open access articles of major scientific databases including PuBMed, SCIENCEDIRECT, EBSCO, SCOPUS, Web of Science, etc.. No significant scientific studies were found relating to the application of yoga in rehabilitation and prevention of sport injury. Four studies were selected based on inclusion criteria. One pilot study has included yoga as part of sport conditioning and has investigated use of yoga for flexibility and incidence of non-contact injuries in baseball athletes. The other studies include a clinical example that has used yoga as part of the seven point program in injury treatment of elite football players, an intervention that has included yoga in high-volume training program and a randomised control trial that has evaluated effect of yoga in flexibility and balance among athletes. Conclusions: There is scope for further studies to examine the effect of yoga as an adjunct intervention in rehabilitation of select sports injuries for athletes in competitive sport. There is potential to include sport-specific yoga programs in athletic training for prevention of non-contact injuries.
Strategies for success as an industrial chemist
Authors: Ribes Carolyn 
Published: December 2018

Abstract
There are multiple factors that contribute to the success of an industrial chemist. In addition to technical knowledge, business acumen and interprofessional skills are required for growth and advancement. The technical expertise that is developed through formal training cannot stagnate; continuous learning is required to remain relevant and drive innovation. Business acumen refers to understanding not only the company’s competitive advantage and financial picture but also the value proposition for your department and yourself. Interprofessional skills, the ability to communicate and work effectively with others, are critical since many industrial projects are multidisciplinary and cross-functional. Recommendations for development in all three areas are described.
Influence of talc and rubber contents on surface replication of polypropylene injection molding application to automotive plastics
Authors: Kuroda Shinichi , Mizutani Atsushi , Ito Hiroshi 
Published: December 2018

Abstract
The influence of talc and rubber contents included in polypropylene (PP) on surface replication properties for microstructure was analyzed. By increasing the talc and rubber contents, surface replication on the injection-molded parts has been reduced. From the surface observation, an uneven microstructure surface was formed for a material containing talc during the shrinkage process. It was confirmed that if the PP resin contains talc, then the correlation between glossiness of the mold and glossiness of the molded product was lost and glossiness was decreased. On the contrary, as the rubber content increased, the replication properties improved. At the same time, generation of the streak pattern in the transferred area, which was generated in the base PP, decreased and glossiness increased. Moreover, the fine uneven structure of the nontransferred area, as observed in the talc-containing material, was not observed in the rubber-containing material.
Routine politeness in American and British English requests: use and non-use of please
Authors: Murphy M. Lynne , Felice Rachele De 
Published: December 2018

Abstract
This paper looks at the use and non-use of please in American and British English requests. The analysis is based on request data from two comparable workplace email corpora, which have been pragmatically annotated to enable retrieval of all request speech acts regardless of formulation. 675 requests are extracted from each of the two corpora; the behaviour of please is analyzed with regard to factors such as imposition level, sentence mood, and modal verb type. Differences in use of please between the two varieties of English can be accounted for by viewing this as a marker of conventional politeness rather than face-threat mitigation in British English and as a marker of relationship asymmetry in American English.
Design and development of the SLAV-INMIO-CICE coupled model for seasonal prediction and climate research
Authors: Fadeev Rostislav Yu. , Ushakov Konstantin V. , Tolstykh Mikhail A. , Ibrayev Rashit A. 
Published: December 2018

Abstract
SLAV–INMIO–CICE is the coupled atmosphere–ocean–ice model developed at Marchuk Institute of Numerical Mathematics (INM) Russian Academy of Sciences (RAS), Shirshov Institute of Oceanology RAS and Hydrometeorological Centre of Russia (HMCR). The model components are coupled using the new version of the own developed Compact Modeling Framework (CMF). This paper presents design of the coupled model and some computational aspects related to the model components coupling. Preliminary evaluation of the coupled model climate and performance are also given.
Rpd3L Contributes to the DNA Damage Sensitivity ofSaccharomyces cerevisiaeCheckpoint Mutants
Authors: Gómez-González Belén , Patel Harshil , Early Anne , Diffley John F X 
Published: December 2018

AbstractDNA replication forks that are stalled by DNA damage activate an S-phase checkpoint that prevents irreversible fork arrest and cell death. The increased cell death caused by DNA damage in budding yeast cells lacking the Rad53 checkpoint protein kinase is partially suppressed by deletion of the EXO1 gene. Using a whole-genome sequencing approach, we identified two additional genes, RXT2 and RPH1, whose mutation can also partially suppress this DNA damage sensitivity. We provide evidence that RXT2 and RPH1 act in a common pathway, which is distinct from the EXO1 pathway. Analysis of additional mutants indicates that suppression works through the loss of the Rpd3L histone deacetylase complex. Our results suggest that the loss or absence of histone acetylation, perhaps at stalled forks, may contribute to cell death in the absence of a functional checkpoint.
El conflicto en las emociones recalcitrantes
Authors: Mesa Alvarado Laura 
Published: December 2018

En general, todas las emociones comparten ciertas características que les son inherentes: tienen conductas asociadas y tienen objetos intencionales; además, en las emociones recalcitrantes el sujeto hace un juicio sobre el objeto intencional que entra en conflicto con la emoción. Un caso típico es el miedo a volar: una persona se rehúsa a volar en avión, pero juzga que no hay nada que implique peligro en esa acción. Dado que las conductas que involucra la emoción son acciones intencionales del sujeto que tienen un objetivo contrario a su juicio, se propone que dichas emociones son irracionales.
Experiencia perceptual, vaguedad y realismo ingenuo
Authors: Amado Manuel Alejandro 
Published: December 2018

Filósofos modernos como Berkeley y Hume desplegaron una argumentación de corte escéptico en contra del llamado realismo ingenuo: la idea de que la experiencia perceptual provee un accesodirecto al mundo. Dicha argumentación ha sido criticada por Michael Martin y John Campbell, quienes reclaman justicia por una nueva forma de realismo ingenuo llamado relacionalista. Se argumenta que tanto el realismo ingenuo como el relacionalista son falsos, y se defiende la tesis central de Berkeley y Hume: no hay experiencias perfectamente verídicas de objetos materiales.
Efecto del nivel de complementación con Metionina-Colina en vacas Holstein durante el periodo de transición sobre las concentraciones hepáticas de triglicéridos, colina y carnitina
Authors: Galvis R. D. , Montoya J. A. , Madrid L. V. 
Published: December 2018

Con el objetivo de evaluar el potencial lipotrópico de metionina-colina en vacas lecheras durante el periodo de transición, dosis de 20 g/d de una Fuente Comercial Protegida de la Degradación Ruminal (FCPDR) de metionina, y sus combinaciones con una FCPDR de colina en dosis de 60 y 120 g/d fueron suministradas a vacas entre el día 260 de gestación y el día 20 posparto. Estas pastoreaban kikuyo (Cenchrus clamdestinum) y recibieron un complemento alimenticio. El día 270 de gestación y a los días 10 y 20 posparto se cuantificaron las concentraciones plasmáticas de Ácidos Grasos No Esterificados (AGNES), β-Hidroxibutirato (BHB) y Triglicéridos (TG), así como las concentraciones hepáticas de triacilglicéridos, de colina, carnitina total, carnitina libre y acil carnitina. Durante el preparto se presentaron los valores significativamente más altos (p < 0.05) de TG plasmáticos y los valores significativamente más bajos (p < 0.05) de AGNES y BHB. Las concentraciones hepáticas de TG, de colina y de las diferentes formas de carnitina no difirieron significativamente entre periodos de muestreo y no se vieron afectadas por la suplementación con metionina-colina. Las concentraciones plasmáticas de BHB aumentaron significativamente (p < 0.05) con la suplementación conjunta con metionina y colina, sugiriendo un aumento en la oxidación de ácidos grasos. Se concluye que con concentraciones bajas de AGNES, la metionina y colina no son nutrientes limitantes para la exportación de TG desde el hígado a la sangre. Bajo esta condición no se observó lipidosis hepática y como consecuencia la suplementación con metionina-colina no ocasionó efectos significativos sobre las concentraciones hepáticas de TG.