bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corticolimbic Mechanisms of Behavioral Inhibition under Threat of Punishment
Authors: Verharen Jeroen P.H. , van den Heuvel Mauri W. , Luijendijk Mieneke , Vanderschuren Louk J.M.J. , Adan Roger A.H. 
Published: March 2019

Being able to limit the pursuit of reward to prevent negative consequences is an important expression of behavioral inhibition. Everyday examples of an inability to exert such control over behavior are the overconsumption of food and drugs of abuse, which are important factors in the development of obesity and addiction, respectively. Here, we use a behavioral task that assesses the ability of male rats to exert behavioral restraint at the mere sight of palatable food during the presentation of an audiovisual threat cue to investigate the corticolimbic underpinnings of behavioral inhibition. We demonstrate a prominent role for the medial prefrontal cortex in the exertion of control over behavior under threat of punishment. Moreover, task engagement relies on function of the ventral striatum, whereas the basolateral amygdala mediates processing of the threat cue. Together, these data show that inhibition of reward pursuit requires the coordinated action of a network of corticolimbic structures.SIGNIFICANCE STATEMENTThere is a need for translational models that allow to dissect mechanisms underlying the processes involved in controlling behavior. In this study, we present a novel behavioral task that assesses the ability of rats to exert behavioral restraint over the consumption of a visually present sucrose pellet during the presentation of an audiovisual threat cue. This task requires relatively little behavioral training and it discerns distinct behavioral impairments, including a failure to retrieve stimulus value, a reduced task engagement, and compromised inhibition of behavior. Using pharmacological inactivations of different regions of the corticolimbic system of the rat, we demonstrate dissociable roles for the prefrontal cortex, amygdala, and striatum in inhibition of reward pursuit under threat of punishment.
La calidad de la democracia en Honduras, 2014-2018: sistema político, sociedad civil e instituciones en perspectiva
Authors: Joo Carlos Ugo Santander , Avila Carlos Federico Domínguez 
Published: March 2019

El artículo explora la evolución reciente, las disputas y prospectivas del régimen democrático existente en Honduras. Se parte de la propuesta teórico-metodológica sustentada por Leonardo Morlino para el estudio de la calidad de la democracia. Ese modelo analítico se desdobla en ocho dimensiones: la participación política, la competencia política, la rendición de cuentas electoral, la rendición de cuentas interinstitucional, el Estado de Derecho, la Responsividad, las libertades, y la solidaridad/ igualdad. El artículo toma en consideración las investigaciones previas de ambos autores en la temática. Así, el texto discute las principales limitaciones y las políticas públicas necesarias para mejorar la calidad de la democracia existente en el país.*** A qualidade da democracia em Honduras, 2014-2018: sistema político, sociedade civil e instituições em perspectiva ***O artigo explora a evolução recente, as disputas e prospectivas do regime democrático existente em Honduras. Parte-se da proposta teórico-metodológica sustentada pelo cientista político Leonardo Morlino para o estudo da qualidade da democracia. Esse modelo analítico se desdobra em oito dimensões: a participação política, a competência política, a prestação de contas eleitoral, a prestação de contas interinstitucional, o Estado de Direito, a Responsividade, as liberdades e a solidariedade/ igualdade. O artigo toma em consideração as pesquisas prévias de ambos os autores na temática. Assim, discute as principais limitações e as políticas públicas necessárias para melhorar a qualidade da democracia existente no país.Palavras-chave: Honduras. Democracia. Sistema Político. Cidadania. Direitos Humanos.
Más allá de organizaciones históricas, las figuras emblemáticas y las prácticas reconocidas. Elementos para repensar al movimiento de derechos humanos en la Argentina
Authors: Crenzel Emílio 
Published: March 2019

La Argentina se destaca, desde el retorno a la democracia en 1983, por la presencia de los derechos humanos en su cultura política. En estas páginas analizaré el papel desempeñado en ese proceso por el movimiento de derechos humanos. Propongo pensar a este movimiento más allá de sus organizaciones históricas, sus figuras emblemáticas y sus prácticas reconocidas incorporando el examen de iniciativas que, desenvueltas por actores no encuadrados en estas organizaciones, contribuyeron a la verdad, la justicia y la memoria respecto de los crímenes de Estado y, con ello, al estatus alcanzado por los derechos humanos en la cultura política del país. *** Além de organizações históricas, figuras emblemáticas e práticas reconhecidas. Elementos para repensar o movimento pelos direitos humanos na Argentina ***A Argentina se destaca, a partir do retorno à democracia em 1983, pela presença dos direitos humanos em sua cultura política. Nestas páginas vou analisar o papel desempenhado nesse processo pelo movimento dos direitos humanos. Proponho pensar nesse movimento para além de suas organizações históricas, figuras emblemáticas e práticas reconhecidas incorporando o exame de iniciativas que, desenvolvidas por atores não enquadrados nessas organizações, contribuíram para a verdade, justiça e memória em relação aos crimes de Estado e, com isso, o status alcançado pelos direitos humanos na cultura política do País.Palavras-chave: Argentina. Movimento dos direitos humanos. Cultura política.
VLSP SHARED TASK: SENTIMENT ANALYSIS
Authors: Nguyen Huyen T M , Nguyen Hung V , Ngo Quyen T , Vu Luong X , Tran Vu Mai , Ngo Bach X , Le Cuong A 
Published: March 2019

Sentiment analysis is a natural language processing (NLP) task of identifying orextracting the sentiment content of a text unit. This task has become an active research topic since the early 2000s. During the two last editions of the VLSP workshop series, the shared task on Sentiment Analysis (SA) for Vietnamese has been organized in order to provide an objective evaluation measurement about the performance (quality) of sentiment analysis tools, and encouragethe development of Vietnamese sentiment analysis systems, as well as to provide benchmark datasets for this task. The rst campaign in 2016 only focused on the sentiment polarity classication, with a dataset containing reviews of electronic products. The second campaign in 2018 addressed the problem of Aspect Based Sentiment Analysis (ABSA) for Vietnamese, by providing two datasets containing reviews in restaurant and hotel domains. These data are accessible for research purpose via the VLSP website vlsp.org.vn/resources. This paper describes the built datasets as well as the evaluation results of the systems participating to these campaigns.
Attitudes and Barriers to Research Among Oncology Trainees in East Africa
Authors: Rubagumya Fidel , Nyagabona Sarah K. , Msami Khadija H. , Manirakiza Achille , Longombe Ahuka N. , Maniragaba Theoneste , Chan Hilary , Paciorek Alan , Zhang Li , Balandya Emmanuel , Germana Leyna H. , Mmbaga Elia J. , Dharsee Nazima , Van Loon Katherine 
Published: March 2019

Abstract

Background
East Africa is one of the fastest growing regions in the world and faces a rising burden of cancer; however, few people are equipped to effectively conduct research in this area.

Materials and Methods
A 31-item questionnaire was distributed to current trainees and recent graduates of the Master in Medicine in Clinical Oncology Program at Muhimbili University of Health and Allied Sciences in Tanzania. Areas that were assessed included (a) demographic information, (b) prior research training, (c) prior and current research activities, (d) attitudes toward the importance of research, and (e) supports and barriers to inclusion of research in an oncology career path.

Results
A total of 30 individuals responded to the survey, of whom 53% (n = 16) were male and 70% (n = 21) identified as current trainees. Among the majority of respondents, attitudes toward research were strongly favorable. Although only 37% (n = 11) reported receiving any formal training in research methodology, 87% (n = 26) reported intentions to incorporate research into their careers. The absence of protected time for research and lack of access to research funding opportunities were identified by a majority of respondents as critical barriers.

Conclusion
A majority of current or recent oncology trainees in Tanzania desire to incorporate research into their careers, but most also lack adequate training in research methodology and longitudinal mentorship. Our future collaboration will focus on creation of appropriate research training curriculums and fostering an environment that catalyzes interprofessional development and transforms and extends context-specific cancer research in East Africa.

Implications for Practice
Current and recent oncology trainees in East Africa expressed a high enthusiasm for research, driven by a sense of urgency related to the burden from cancer that the region faces. This highlights the need for cancer research training and mentorship in this setting. This work hypothesizes that African principal investigators can operate effectively if proper attention is given to selection and provision of high-quality foundational didactic training to learn the theory and implementation of research as well as to the development of an environment conducive to mentoring.
Protein Phosphatase 1 Inhibitor–1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter
Authors: Penton David , Moser Sandra , Wengi Agnieszka , Czogalla Jan , Rosenbaek Lena Lindtoft , Rigendinger Fritz , Faresse Nourdine , Martins Joana R. , Fenton Robert A. , Loffing-Cueni Dominique , Loffing Johannes 
Published: March 2019

Significance Statement
Stimuli that elevate cAMP, including β-adrenergic agonists and parathyroid hormone, increase phosphorylation (and hence activity) of the thiazide-sensitive NaCl cotransporter (NCC) in the distal convoluted tubule. The protein phosphatase 1 (PP1) modulates NCC phosphorylation, but its role and the mechanism regulating its function are obscure. The authors used in vitro and ex vivo approaches to demonstrate that a PP1 inhibitor, protein phosphatase 1 inhibitor–1 (I1), mediates the effects of cAMP-elevating hormones on NCC. They propose a novel signaling pathway in which protein kinase A–dependent phosphorylation of I1 inhibits the PP1-dependent dephosphorylation of NCC. Given NCC’s critical role in renal control of ion homeostasis and BP, this pathway may contribute to the physiologic regulation of NCC and the development of arterial hypertension in the context of abnormal hormonal stimulation.

Background
A number of cAMP-elevating hormones stimulate phosphorylation (and hence activity) of the NaCl cotransporter (NCC) in the distal convoluted tubule (DCT). Evidence suggests that protein phosphatase 1 (PP1) and other protein phosphatases modulate NCC phosphorylation, but little is known about PP1’s role and the mechanism regulating its function in the DCT.

Methods
We used ex vivo mouse kidney preparations to test whether a DCT-enriched inhibitor of PP1, protein phosphatase 1 inhibitor–1 (I1), mediates cAMP’s effects on NCC, and conducted yeast two-hybrid and coimmunoprecipitation experiments in NCC-expressing MDCK cells to explore protein interactions.

Results
Treating isolated DCTs with forskolin and IBMX increased NCC phosphorylation via a protein kinase A (PKA)–dependent pathway. Ex vivo incubation of mouse kidney slices with isoproterenol, norepinephrine, and parathyroid hormone similarly increased NCC phosphorylation. The cAMP-induced stimulation of NCC phosphorylation strongly correlated with the phosphorylation of I1 at its PKA consensus phosphorylation site (a threonine residue in position 35). We also found an interaction between NCC and the I1-target PP1. Moreover, PP1 dephosphorylated NCC in vitro, and the PP1 inhibitor calyculin A increased NCC phosphorylation. Studies in kidney slices and isolated perfused kidneys of control and I1-KO mice demonstrated that I1 participates in the cAMP-induced stimulation of NCC.

Conclusions
Our data suggest a complete signal transduction pathway by which cAMP increases NCC phosphorylation via a PKA-dependent phosphorylation of I1 and subsequent inhibition of PP1. This pathway might be relevant for the physiologic regulation of renal sodium handling by cAMP-elevating hormones, and may contribute to salt-sensitive hypertension in patients with endocrine disorders or sympathetic hyperactivity.
Implementasi Metode Profile Matching Terhadap Sistem Pendukung Keputusan Penerimaan Dana Zakat pada Badan Amil Zakat Pertamina (BAZMA)
Authors: Fadilah Evi 
Published: March 2019

<p class="Abstract"><em>Abstrak</em>–-Badan Amil Zakat Pertamina (BAZMA) merupakan badan pengelola zakat saat ini secara aktif telah menerima dan menyalurkan zakat kepada mustahik. Masalah yang dihadapi saat ini adalah penentuan penerima dana zakat harus membandingkan hasil survey satu persatu sehingga didapat siapa yang paling berhak menerima dana zakat membuat penilaian subjektif. Agar petugas BAZMA tidak salah dalam penyaluran dana zakat maka dibutuhkan sistem pendukung keputusan dalam penentuan penerima dana zakat dimana pada sistem tersebut telah ditentukan penilaian berdasarkan aspek, kriteria-kriteria dan subkriteria. Karena standar yang menjadi tolak ukur telah ditentukan maka salah satu metode yang cocok dalam pembuatan sistem pendukung keputusan ini yaitu profile matching. Metode Profile Matching sebagai solusi alternative pilihan, dengan keakuratan hasil yang baik berupa perangkingan dan dapat mengurangi terjadinya penilaian secara subyektif. Sistem yang dibuat dapat mempermudah bagian administrasi dalam pengolahan data mustahik, membantu kepala koordinator dalam pengambilan keputusan dengan cara yang lebih cepat, keakuratan hasil yang baik dan dapat mengurangi penilaian secara subjektif dalam penentuan penerima dana zakat.</p>
Momentum Conservative Scheme for Simulating Wave Runup and Underwater Landslide
Authors: Adytia Didit 
Published: March 2019

This paper focuses on the numerical modelling and simulation of tsunami waves triggered by an underwater landslide. The equation of motion for water waves is represented by the Nonlinear Shallow Water Equations (NSWE). Meanwhile, the motion of underwater landslide is modeled by incorporating a term for bottom motion into the NSWE. The model is solved numerically by using a finite volume method with a momentum conservative staggered grid scheme that is proposed by Stelling &amp; Duinmeijer 2003 [12]. Here, we modify the scheme for the implementation of bottom motion. The accuracy of the implementation for representing wave runup and rundown is shown by performing the runup of harmonic wave as proposed by Carrier &amp; Greenspan 1958 [2], and also solitary wave runup of Synolakis, 1986 [14], for both breaking and non-breaking cases. For the underwater landslide, result of the simulation is compared with simulation using the Boundary Integral Equation Model (BIEM) that is performed by Lynett and Liu, 2002 [9].
New Tech Accelerator Teams With Big Operators to Solve the Pilot Problem
Authors: Jacobs Trent 
Published: March 2019

Proving out and then scaling up a new technology are among the most challenging feats in the oil and gas business—about as dicey as drilling a wildcat well of old. What could make this uphill climb much steeper? Finding that no one wants to even test your innovation.
The scenario is so common to the upstream sector that it has led to the creation of a new kind of venture capital fund based in Houston. Formally launched this year, Eunike Ventures is combining the roles of investor and technology accelerator with a third and unique prong: guaranteed pilot projects. Equinor, Anadarko, and Hess are the first oil companies to underwrite this experiment as corporate sponsors.
“[Startups] can get all the funding they want and still not get any pilots,” explained Amy Henry, adding that, “the issue is making that connection point with the operators.”
As chief executive officer and cofounder of Eunike, Henry sees the problem not just as an impediment to the growth of early-stage innovators but also the industry’s much-discussed quest to modernize itself through the adoption of new technologies.
The industry veteran has touched all the angles of technology uptake during her career, which was punctuated by roles inside Shell’s venture and unconventional units, along with a stint in Malaysia as the chief financial officer of Petronas’ unconventional business.
Upon starting Eunike, she realized that the solution to a more efficient technology evaluation and adoption process was rather simple: “You need to have operators have some skin the game.”
This is different than the current formula that many of the biggest oil and gas producers have subscribed to, which dates back to the late 1990s when many of them formed venture units. The snag these groups have historically dealt with is that their investments in a new technology do not always persuade frontline field managers to share the risk by deploying it, even at a small scale.
If it can be boiled down to one thing, then the bottleneck is really just about budgeting.
“We understood the problem,” said Eunike’s other cofounder and chief operating officer, Thomas Henry, as he reflected on innovation projects he worked on over nearly 3 decades with Shell. “We couldn’t get our own assets to buy into some of the technologies that we developed—nobody was willing to fork up the money for field trials.”
Under this new scheme, the issue is circumvented by funding a startup only after at least one of the operators in the “alliance” commit to a paid pilot. This is the trigger for Eunike to make an investment in the startup.
Amy Henry said this underlines the fiduciary responsibility Eunike has to both the startup and the operators. It also reveals another aspect of the business, which is to help the operators accept the failure of a pilot despite how much they may want it to work out.
“We’re not eliminating, but we are reducing internal bias,” she said. “We’ve all worked in oil and gas companies and had special projects, and it is always hard to say that something is not going well.”
3D- vs. 4K-Display System - Influence of "State-of-the-art"-Display Technique On Surgical Performance (IDOSP-Study) in minimal invasive surgery: protocol for a randomized cross-over trial
Authors: Wahba Roger , Datta Rabi R , Hedergott Andrea , Bußhoff Jana , Bruns Thomas , Kleinert Robert , Dieplinger Georg , Fuchs Hans , Giezelt Caroline , Möller Desdemona , Hellmich Martin , Bruns Christiane J , Stippel Dirk L 
Published: March 2019

Abstract
Background
Three-dimensional (3D) stereoscopic vision is crucial to perform any kind of manual tasks. The reduction from real life 3D- to virtual two-dimensional (2D) sight is a major challenge in minimal invasive surgery (MIS). 3D-display technique has shown to reduce operation time, mistakes, and to improve the learning curve. Therefore it seems to optimize surgical performance for novice and experienced surgeons. Inspired by consumer electronics 4K-display technique was recently introduced to MIS. Due to its high resolution and zoom-effect surgeons should benefit from it. Aim of this study is to evaluate if “state-of-the-art” 3D- versus 4K- display techniques could influence surgical performance.

Methods
A randomized cross-over single-institution single-blinded trial is designed. It compares the primary outcome parameter “surgical performance”, represented by “performance time “ and “number of mistakes”, using a passive polarizing 3D- and a 4K-display system (2 arms) to perform different tasks in a minimal invasive/laparoscopic training parkour. Secondary outcome parameters are the mental stress load (NASA task load index) and the learning curve. Unexperienced novices (medical students), non-board certified and board-certified abdominal surgeons participate in the trial (i.e. level of experience, 3 strata). The parkour consists of 7 tasks (novices 5 tasks), which will be repeated 3 times. The 1st run of the parkour will be performed with the randomized display system, the 2nd run with the other one. After each run, the mental stress load is measured. After completion of the parkour, all participants are evaluated by an ophthalmologist for visual acuity and stereoscopic vision with five tests. Assuming a correlation of 0.5 between measurements per subject a sample-size of 36 per stratum is required to detect a standardized effect of 0.5 (including additional 5% for a non-parametric approach) with a power of 80% at two-sided type I error of 5%. Thus, altogether 108 subjects need to be enrolled.

Discussion
Complex surgical procedures are performed in minimal invasive/laparoscopic technique. This study should provide some evidence to decide which display technique a surgeon could choose to optimize his performance.

Trial Registration
This trial is registered at clinicaltrials.gov (trial number: NCT 03445429, registered February 7, 2018, http://www.clinicaltrials.gov)
Evaluation of the effect of oral taurine supplementation on levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind randomized controlled trial
Authors: Haidari Fatemeh , Asadi Maryam , Mohammadi-asl Javad , Ahmadi-angali Kambiz 
Published: March 2019

Abstract
Background: according to studies, the function of FGFs are disturbed in obesity. So that, serum level of FGFs are correlated with insulin resistance and obesity. Besides the effects of eicosapentaenoic acid on serum FGF21 concentrations, the effect of other nutrients on FGFs is not clear. Since obesity as an important health problem is rising in the world and on the other side, taurine (Tau) biosynthesis is reduced by adipose tissue-derived factors in obesity, the effects of Tau and a weight loss diet on obesity need to be investigated further. Methods: We will conduct a 2 month’s double-blind, parallel-group, randomized controlled clinical trial to investigate the effect of Tau supplementation on serum levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet. Discussion: we will determine the other advantages of a weight loss diet on metabolic risk factors. Moreover, for the first time, the effects of a weight loss diet along with Tau supplementation on these variables will be assessed.