bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple‐Hour‐Ahead Forecast of the Dst Index Using a Combination of Long Short‐Term Memory Neural Network and Gaussian Process
Authors: Gruet M. A. , Chandorkar M. , Sicard A. , Camporeale E. 
Published: June 2018

AbstractIn this study, we present a method that combines a Long Short‐Term Memory (LSTM) recurrent neural network with a Gaussian process (GP) model to provide up to 6‐hr‐ahead probabilistic forecasts of the Dst geomagnetic index. The proposed approach brings together the sequence modeling capabilities of a recurrent neural network with the error bars and confidence bounds provided by a GP. Our model is trained using the hourly OMNI and Global Positioning System (GPS) databases, both of which are publicly available. We first develop a LSTM network to get a single‐point prediction of Dst. This model yields great accuracy in forecasting the Dst index from 1 to 6 hr ahead, with a correlation coefficient always higher than 0.873 and a root‐mean‐square error lower than 9.86. However, even if global metrics show excellent performance, it remains poor in predicting intense storms (Dst < −250 nT) 6 hr in advance. To improve it and to obtain probabilistic forecasts, we combine the LSTM model obtained with a GP and evaluate the hybrid predictor using the receiver operating characteristic curve and the reliability diagram. We conclude that this hybrid methodology provides improvements in the forecast of geomagnetic storms, from 1 to 6 hr ahead.
Gain in polycrystalline Nd-doped alumina: leveraging length scales to create a new class of high-energy, short pulse, tunable laser materials
Authors: Penilla Elias H. , Devia-Cruz Luis F. , Duarte Matthew A. , Hardin Corey L. , Kodera Yasuhiro , Garay Javier E. 
Published: June 2018

AbstractTraditionally accepted design paradigms dictate that only optically isotropic (cubic) crystal structures with high equilibrium solubilities of optically active ions are suitable for polycrystalline laser gain media. The restriction of symmetry is due to light scattering caused by randomly oriented anisotropic crystals, whereas the solubility problem arises from the need for sufficient active dopants in the media. These criteria limit material choices and exclude materials that have superior thermo-mechanical properties than state-of-the-art laser materials. Alumina (Al2O3) is an ideal example; it has a higher fracture strength and thermal conductivity than today’s gain materials, which could lead to revolutionary laser performance. However, alumina has uniaxial optical proprieties, and the solubility of rare earths (REs) is two-to-three orders of magnitude lower than the dopant concentrations in typical RE-based gain media. We present new strategies to overcome these obstacles and demonstrate gain in a RE-doped alumina (Nd:Al2O3) for the first time. The key insight relies on tailoring the crystallite size to other important length scales—the wavelength of light and interatomic dopant distances, which minimize optical losses and allow successful Nd doping. The result is a laser gain medium with a thermo-mechanical figure of merit of Rs~19,500 Wm−1 a 24-fold and 19,500-fold improvements over the high-energy-laser leaders Nd:YAG (Rs~800 Wm−1) and Nd:Glass (Rs~1 Wm−1), respectively. Moreover, the emission bandwidth of Nd:Al2O3 is broad: ~13 THz. The successful demonstration of gain and high bandwidth in a medium with superior Rs can lead to the development of lasers with previously unobtainable high-peak powers, short pulses, tunability, and high-duty cycles.
All-optical active THz metasurfaces for ultrafast polarization switching and dynamic beam splitting
Authors: Cong Longqing , Srivastava Yogesh Kumar , Zhang Huifang , Zhang Xueqian , Han Jiaguang , Singh Ranjan 
Published: June 2018

AbstractMiniaturized ultrafast switchable optical components with an extremely compact size and a high-speed response will be the core of next-generation all-optical devices instead of traditional integrated circuits, which are approaching the bottleneck of Moore’s Law. Metasurfaces have emerged as fascinating subwavelength flat optical components and devices for light focusing and holography applications. However, these devices exhibit a severe limitation due to their natural passive response. Here we introduce an active hybrid metasurface integrated with patterned semiconductor inclusions for all-optical active control of terahertz waves. Ultrafast modulation of polarization states and the beam splitting ratio are experimentally demonstrated on a time scale of 667 ps. This scheme of hybrid metasurfaces could also be extended to the design of various free-space all-optical active devices, such as varifocal planar lenses, switchable vector beam generators, and components for holography in ultrafast imaging, display, and high-fidelity terahertz wireless communication systems.
Add-on plasmonic patch as a universal fluorescence enhancer
Authors: Luan Jingyi , Morrissey Jeremiah J. , Wang Zheyu , Derami Hamed Gholami , Liu Keng-Ku , Cao Sisi , Jiang Qisheng , Wang Congzhou , Kharasch Evan D. , Naik Rajesh R. , Singamaneni Srikanth 
Published: June 2018

AbstractFluorescence-based techniques are the cornerstone of modern biomedical optics, with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, the weakness of the fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect, and quantify biological species with low abundance. Here, we report a simple and universal method based on a flexible and conformal elastomeric film with adsorbed plasmonic nanostructures, which we term a “plasmonic patch,” that provides large (up to 100-fold) and uniform fluorescence enhancement on a variety of surfaces through simple transfer of the plasmonic patch to the surface. We demonstrate the applications of the plasmonic patch in improving the sensitivity and limit of detection (by more than 100 times) of fluorescence-based immunoassays implemented in microtiter plates and in microarray format. The novel fluorescence enhancement approach presented here represents a disease, biomarker, and application agnostic ubiquitously applicable fundamental and enabling technology to immediately improve the sensitivity of existing analytical methodologies in an easy-to-handle and cost-effective manner, without changing the original procedures of the existing techniques.
Single-shot BOTDA based on an optical chirp chain probe wave for distributed ultrafast measurement
Authors: Zhou Dengwang , Dong Yongkang , Wang Benzhang , Pang Chao , Ba Dexin , Zhang Hongying , Lu Zhiwei , Li Hui , Bao Xiaoyi 
Published: June 2018

AbstractBrillouin optical time-domain analysis (BOTDA) requires frequency mapping of the Brillouin spectrum to obtain environmental information (e.g., temperature or strain) over the length of the sensing fiber, with the finite frequency-sweeping time-limiting applications to only static or slowly varying strain or temperature environments. To solve this problem, we propose the use of an optical chirp chain probe wave to remove the requirement of frequency sweeping for the Brillouin spectrum, which enables distributed ultrafast strain measurement with a single pump pulse. The optical chirp chain is generated using a frequency-agile technique via a fast-frequency-changing microwave, which covers a larger frequency range around the Stokes frequency relative to the pump wave, so that a distributed Brillouin gain spectrum along the fiber is realized. Dynamic strain measurements for periodic mechanical vibration, mechanical shock, and a switch event are demonstrated at sampling rates of 25 kHz, 2.5 MHz and 6.25 MHz, respectively. To the best of our knowledge, this is the first demonstration of distributed Brillouin strain sensing with a wide-dynamic range at a sampling rate of up to the MHz level.
Ixodes scapularis does not harbor a stable midgut microbiome
Authors: Ross Benjamin D , Hayes Beth , Radey Matthew C , Lee Xia , Josek Tanya , Bjork Jenna , Neitzel David , Paskewitz Susan , Chou Seemay , Mougous Joseph D 
Published: June 2018

Abstract
Hard ticks of the order Ixodidae serve as vectors for numerous human pathogens, including the causative agent of Lyme Disease Borrelia burgdorferi. Tick-associated microbes can influence pathogen colonization, offering the potential to inhibit disease transmission through engineering of the tick microbiota. Here, we investigate whether B. burgdorferi encounters abundant bacteria within the midgut of wild adult Ixodes scapularis, its primary vector. Through the use of controlled sequencing methods and confocal microscopy, we find that the majority of field-collected adult I. scapularis harbor limited internal microbial communities that are dominated by endosymbionts. A minority of I. scapularis ticks harbor abundant midgut bacteria and lack B. burgdorferi. We find that the lack of a stable resident midgut microbiota is not restricted to I. scapularis since extension of our studies to I. pacificus, Amblyomma maculatum, and Dermacentor spp showed similar patterns. Finally, bioinformatic examination of the B. burgdorferi genome revealed the absence of genes encoding known interbacterial interaction pathways, a feature unique to the Borrelia genus within the phylum Spirochaetes. Our results suggest that reduced selective pressure from limited microbial populations within ticks may have facilitated the evolutionary loss of genes encoding interbacterial competition pathways from Borrelia.
Unmasking chloride attack on the passive film of metals
Authors: Zhang B. , Wang J. , Wu B. , Guo X. W. , Wang Y. J. , Chen D. , Zhang Y. C. , Du K. , Oguzie E. E. , Ma X. L. 
Published: June 2018

AbstractNanometer-thick passive films on metals usually impart remarkable resistance to general corrosion but are susceptible to localized attack in certain aggressive media, leading to material failure with pronounced adverse economic and safety consequences. Over the past decades, several classic theories have been proposed and accepted, based on hypotheses and theoretical models, and oftentimes, not sufficiently nor directly corroborated by experimental evidence. Here we show experimental results on the structure of the passive film formed on a FeCr15Ni15 single crystal in chloride-free and chloride-containing media. We use aberration-corrected transmission electron microscopy to directly capture the chloride ion accumulation at the metal/film interface, lattice expansion on the metal side, undulations at the interface, and structural inhomogeneity on the film side, most of which had previously been rejected by existing models. This work unmasks, at the atomic scale, the mechanism of chloride-induced passivity breakdown that is known to occur in various metallic materials.
Placental H3K27me3 establishes female resilience to prenatal insults
Authors: Nugent Bridget M. , O’Donnell Carly M. , Epperson C. Neill , Bale Tracy L. 
Published: June 2018

AbstractAlthough sex biases in disease presentation are well documented, the mechanisms mediating vulnerability or resilience to diseases are unknown. In utero insults are more likely to produce detrimental health outcomes for males versus females. In our mouse model of prenatal stress, male offspring experience long-term dysregulation of body weight and hypothalamic pituitary adrenal stress axis dysfunction, endophenotypes of male-biased neurodevelopmental disorders. Placental function is critical for healthy fetal development, and we previously showed that sex differences in placental O-linked N-acetylglucosamine transferase (OGT) mediate the effects of prenatal stress on neurodevelopmental programming. Here we show that one mechanism whereby sex differences in OGT confer variation in vulnerability to prenatal insults is by establishing sex-specific trophoblast gene expression patterns and via regulation of the canonically repressive epigenetic modification, H3K27me3. We demonstrate that high levels of H3K27me3 in the female placenta create resilience to the altered hypothalamic programming associated with prenatal stress exposure.
Prophylactic Intravenous Lidocaine at Different Doses for Fentanyl-Induced Cough (FIC): A Meta-Analysis
Authors: Tan Wulin , Li Si , Liu Xiaochen , Gao Xiang , Huang Wenqi , Guo Junying , Wang Zhongxing 
Published: June 2018

AbstractTo evaluate whether different doses of intravenous lidocaine are effective at preventing fentanyl-induced cough (FIC), we searched PubMed, Scopus, Cochrane Library, EMBASE and Web of Science, according to predefined criteria, for all articles published until June 2017. A meta-analysis and subgroup analysis were performed by combining the reported incidence of FIC. The odds ratio (OR) was used as a summary statistic. Eleven articles were included, with 965 patients in the lidocaine group and 745 patients in the control group. A pooled analysis indicated that the overall incidence of FIC was significantly different between the lidocaine group and the control group (OR, 0.27; 95% confidence interval (CI), 0.21–0.35; P < 0.05), as well as between the adult and paediatric subgroups. Sensitivity analysis showed that the results were stable. Subgroup analyses showed that compared to a placebo, both low (0.5–1.0 mg/kg) and high doses of lidocaine (1.5–2.0 mg/kg) were effective at reducing FIC incidence. There was no significant difference between low or high doses of lidocaine. Fentanyl doses added no significant heterogeneity as shown by meta-regression. The findings of this meta-analysis indicate that prophylactic intravenous lidocaine is effective at preventing FIC in both adults and children.
Phenotypes of Jackhammer esophagus in patients with typical symptoms of gastroesophageal reflux disease responsive to proton pump inhibitors
Authors: Kristo Ivan , Schwameis Katrin , Maschke Svenja , Kainz Alexander , Rieder Erwin , Paireder Matthias , Jomrich Gerd , Schoppmann Sebastian F. 
Published: June 2018

AbstractThis trial was designed to assess the prevalence and characteristics of Jackhammer esophagus (JE), a novel hypercontractile disorder associated with progression to achalasia and limited outcomes following anti-reflux surgery in patients with typical symptoms of GERD and responsiveness to proton pump inhibitor (PPI) therapy. Consecutive patients, who were referred for surgical therapy because of PPI responsive typical symptoms of GERD, were prospectively assessed between January 2014 and May 2017. Patients diagnosed with JE subsequently underwent rigorous clinical screening including esophagogastroduodenoscopy (EGD), ambulatory pH impedance monitoring off PPI and a PPI trial. Out of 2443 evaluated patients, 37 (1.5%) subjects with a median age of 56.3 (51.6; 65) years were diagnosed with JE and left for final analysis. Extensive testing resulted in 16 (43.2%) GERD positive patients and 5 (13.9%) participants were observed to have an acid hypersensitive esophagus. There were no clinical parameters that differentiated phenotypes of JE. The prevalence of JE in patients with typical symptoms of GERD and response to PPI therapy is low. True GERD was diagnosed in less than half of this selected cohort, indicating the need for objective testing to stratify phenotypes of JE. (NCT03347903)
Modeling and Optimizing a New Culture Medium for In Vitro Rooting of G×N15 Prunus Rootstock using Artificial Neural Network-Genetic Algorithm
Authors: Arab Mohammad Mehdi , Yadollahi Abbas , Eftekhari Maliheh , Ahmadi Hamed , Akbari Mohammad , Khorami Saadat Sarikhani 
Published: June 2018

AbstractThe main aim of the present investigation is modeling and optimization of a new culture medium for in vitro rooting of G×N15 rootstock using an artificial neural network-genetic algorithm (ANN-GA). Six experiments for assessing different media culture, various concentrations of Indole – 3- butyric acid, different concentrations of Thiamine and Fe-EDDHA were designed. The effects of five ionic macronutrients (NH4+, NO3−, Ca2+, K+ and Cl−) on five growth parameters [root number (RN), root length (RL), root percentage (R%), fresh (FW) and dry weight (DW)] were evaluated using the ANN-GA method. The R2 correlation values of 0.88, 0.88, 0.98, 0.94 and 0.87 between observed and predicted values were acquired for all five growth parameters, respectively. The ANN-GA results indicated that among the input variables, K+ (7.6) and NH4+ (4.4), K+ (7.7) and Ca2+ (2.8), K+ (36.7) and NH4+ (4.3), K+ (14.7) and NH4+ (4.4) and K+ (7.6) and NH4+ (4.3) had the highest values of variable sensitivity ratio (VSR) in the data set, for RN, RL, R%, FW and DW, respectively. ANN-GA optimized LS medium for G×N15 rooting contained optimized amounts of 1 mg L−1 IBA, 100, 150, or 200 mg L−1 Fe-EDDHA and 1.6 mg L−1 Thiamine. The efficiency of the optimized culture media was compared to other standard media for Prunus rooting and the results indicated that the optimized medium is more efficient than the others.
Dispersion characteristics of radioactive materials estimated by wind patterns
Authors: Yoshikane Takao , Yoshimura Kei 
Published: June 2018

AbstractThe radioactive materials are generally concentrated downwind of their origins when the prevailing winds blow continuously in one direction. If this principle determined the pattern of dispersion in all cases, dispersion directions could be estimated by wind patterns. However, this hypothesis has not been sufficiently verified because of the complexity of dispersion processes and weather systems. Here, we show that dispersion directions, which are divided into four ranges, can be estimated by wind patterns using a machine learning approach. The five-year average hit rates of the directions of dispersion estimated using near-surface winds exceed 0.85 in all months. The dispersion directions can be estimated up to 33 hours in advance using forecast winds. In particular, high hit rates exceeding 0.95 are achieved in January and March, when large-scale weather systems dominate. These results indicate that the dispersion directions are determined by the wind patterns that correspond to large-scale weather systems and diurnal circulation patterns in most cases. Our findings also provide more reliable information on dispersion patterns with reduced uncertainties, given that reasonable skill is achieved at a sufficient lead time for evacuation.
Rigid External Distraction with Intranasal Bone-borne Traction Hooks for Midfacial Hypoplasia
Authors: Zheng Yilue , Tong Haizhou , Yin Ningbei , Niu Feng , Zhao Zhenmin , Song Tao 
Published: June 2018

AbstractRigid external distraction is currently performed to correct cases of severe maxillary hypoplasia. As an improvement of this technique, we propose the use of an intranasal bone-borne traction hook. This study is a retrospective chart review of the intranasal bone-borne traction hooks used in the treatment of severe maxillary hypoplasia. There were 110 patients treated with the hooks from 2005 to 2017. The maximum traction force was 7.75 kg, and there were few complications encountered during distraction. There were 76 patients who had the hooks removed under local anaesthesia. A cephalometric analysis was conducted in 56 patients. The average advancement of A-point was 9.9 ± 4.2 mm, 8.4 ± 2.5 mm, 11.0 ± 3.7 mm, 17.9 ± 4.4 mm for the trans-sutural distraction osteogenesis (DO), maxillary anterior segment DO, Le Fort I osteotomy DO and Le Fort III/II osteotomy DO, respectively. The average changes of sella-nasion-point A (SNA) were 8.89 ± 4.30 degrees, 8.21 ± 3.17 degrees, 10.49 ± 3.26 degrees, and 15.10 ± 4.00 degrees, respectively. The A point-nasion-B point (ANB) also showed increases in all procedures with P < 0.001. In conclusion, this technique sufficiently advances the midface and ensures the scars are concealed in the nasal base. The traction hook can bear a large traction force, causes minimal complications and is easily removed.
Inductively actuated micro needles for on-demand intracellular delivery
Authors: Kavaldzhiev Mincho N. , Perez Jose E. , Sougrat Rachid , Bergam Ptissam , Ravasi Timothy , Kosel Jürgen 
Published: June 2018

AbstractMethods that provide controlled influx of molecules into cells are of critical importance for uncovering cellular mechanisms, drug development and synthetic biology. However, reliable intracellular delivery without adversely affecting the cells is a major challenge. We developed a platform for on-demand intracellular delivery applications, with which cell membrane penetration is achieved by inductive heating of micro needles. The micro needles of around 1 μm in diameter and 5 μm in length are made of gold using a silicon-based micro fabrication process that provides flexibility with respect to the needles’ dimensions, pitch, shell thickness and the covered area. Experiments with HCT 116 colon cancer cells showed a high biocompatibility of the gold needle platform. Transmission electron microscopy of the cell-needle interface revealed folding of the cell membrane around the needle without penetration, preventing any delivery, which was confirmed using the EthD-1 fluorescent dye. The application of an alternating magnetic field, however, resulted in the delivery of EthD-1 by localized heating of the micro needles. Fluorescence quantification showed that intracellular delivery, with as high as 75% efficiency, is achieved for specific treatment times between 1 and 5 minutes. Overexposure of the cells to the heated micro needles, i.e. longer magnetic field application, leads to an increase in cell death, which can be exploited for cleaning the platform. This method allows to perform intracellular deliver by remotely activating the micro needles via a magnetic field, and it is controlled by the application time, making it a versatile and easy to use method. The wireless actuation could also be an attractive feature for in-vivo delivery and implantable devices.
Ultraviolet Hyperspectral Interferometric Microscopy
Authors: Ojaghi Ashkan , Fay Meredith E. , Lam Wilbur A. , Robles Francisco E. 
Published: June 2018

AbstractUltraviolet (UV) spectroscopy is a powerful tool for quantitative (bio)chemical analysis, but its application to molecular imaging and microscopy has been limited. Here we introduce ultraviolet hyperspectral interferometric (UHI) microscopy, which leverages coherent detection of optical fields to overcome significant challenges associated with UV spectroscopy when applied to molecular imaging. We demonstrate that this method enables quantitative spectral analysis of important endogenous biomolecules with subcellular spatial resolution and sensitivity to nanometer-scaled structures for label-free molecular imaging of live cells.