bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing online consultations in primary care: a mixed-method evaluation extending normalisation process theory through service co-production
Authors: Farr Michelle , Banks Jonathan , Edwards Hannah B , Northstone Kate , Bernard Elly , Salisbury Chris , Horwood Jeremy 
Published: March 2018

ObjectivesTo examine patient and staff views, experiences and acceptability of a UK primary care online consultation system and ask how the system and its implementation may be improved.DesignMixed-method evaluation of a primary care e-consultation system.SettingPrimary care practices in South West England.MethodsQualitative interviews with 23 practice staff in six practices. Patient survey data for 756 e-consultations from 36 practices, with free-text survey comments from 512 patients, were analysed thematically. Anonymised patients’ records were abstracted for 485 e-consultations from eight practices, including consultation types and outcomes. Descriptive statistics were used to analyse quantitative data. Analysis of implementation and the usage of the e-consultation system were informed by: (1) normalisation process theory, (2) a framework that illustrates how e-consultations were co-produced and (3) patients’ and staff touchpoints.ResultsWe found different expectations between patients and staff on how to use e-consultations ‘appropriately’. While some patients used the system to try and save time for themselves and their general practitioners (GPs), some used e-consultations when they could not get a timely face-to-face appointment. Most e-consultations resulted in either follow-on phone (32%) or face-to-face appointments (38%) and GPs felt that this duplicated their workload. Patient satisfaction of the system was high, but a minority were dissatisfied with practice communication about their e-consultation.ConclusionsWhere both patients and staff interact with technology, it is in effect ‘co-implemented’. How patients used e-consultations impacted on practice staff’s experiences and appraisal of the system. Overall, the e-consultation system studied could improve access for some patients, but in its current form, it was not perceived by practices as creating sufficient efficiencies to warrant financial investment. We illustrate how this e-consultation system and its implementation can be improved, through mapping the co-production of e-consultations through touchpoints.
The only way is up – on Mesozoic uplifts and basin inversion events in SE Poland
Authors: Krzywiec Piotr , Stachowska Aleksandra , Stypa Agata 
Published: March 2018

Abstract
The inversion of a sedimentary basin could be associated with compressional reactivation of basin-forming normal faults, upwards movement of the basement blocks and partial or complete erosion of its sedimentary infill. Basin inversion might be also related to whole-basin uplift that is not linked to the reactivation of basement faults, and results in the development of regional stratigraphic gaps and unconformities. Both types of basin inversion have been documented in SE Poland using seismic data. Regional NW–SE seismic profiles illustrate earliest Late Jurassic (earliest Oxfordian) and earliest Late Cretaceous (Cenomanian) regional unconformities related to regional basin-scale uplifts in the SE segment of the Polish Basin. Late Cretaceous (Turonian?–Maastrichtian) progressive uplift of the Mid-Polish Swell has been documented along the NE border zone of this regional anticlinal structure. The Upper Cretaceous inversion-related sedimentary succession is characterized by an overall progradational character directed from the SW towards the NE. Buried contourite drifts that were detected within the Upper Cretaceous succession using seismic data indicate the existence of contour currents encircling inversion-related intrabasinal morphological barriers. A new tectonic scenario of the Mesozoic evolution of SE Poland would have a significant impact on the modelling of tectonic subsidence and the history of petroleum systems.
Telenephrology: Providing Healthcare to Remotely Located Patients with Chronic Kidney Disease
Authors: Tan Judy , Mehrotra Anita , Nadkarni Girish N. , He John Cijiang , Langhoff Erik , Post James , Galvao-Sobrinho Carlos , Thode Jr. Henry C. , Rohatgi Rajeev 
Published: March 2018

<b><i>Background:</i></b> Chronic kidney disease (CKD) patients who live far (&#x3e;30 miles) from their nephrologist experience lower rates of clinic visit adherence, limited access to treatment, and higher rates of hospitalization and mortality than patients who live in close proximity to their nephrologist. Strategies to minimize disparities between urban and remotely located CKD patients are needed. The purpose of this study was to determine whether adherence to clinic visits and clinical outcomes in the remote management of CKD via telenephrology is comparable to in-person conventional care. <b><i>Methods:</i></b> Renal clinic adherence and composite outcomes of death, end-stage renal disease (ESRD), or doubling of serum creatinine (Cr) were measured in geographically remote Hudson Valley VA Medical Center (HVVAMC) CKD patients enrolled in telenephrology (<i>n</i> = 112) and CKD patients enrolled in the Bronx VAMC renal clinic (<i>n</i> = 116). <b><i>Results:</i></b> Prior to implementing the telenephrology service, 53.1% of scheduled visits of rural HVVAMC patients to the Bronx VAMC renal clinic were either cancelled or were “no-shows.” This was reduced by nearly half (28.5%) after instituting telenephrology (<i>p</i> &#x3c; 0.001). Moreover, the frequency of attending appointments was greater in the telenephrology (71.9%) vs. in-person Bronx VA cohort (61.0%). The incidence of the composite outcome of death, ESRD, or doubling of Cr was similar between both groups (<i>p</i> = 0.96) over 2 years of follow-up. <b><i>Conclusions:</i></b> Remote CKD care delivered through telenephrology improves renal clinic visit adherence while delivering comparable renal outcomes. Application of this technology is a promising method to provide access to care to rural CKD patients and to minimize the disparity between urban/rural patients.
A Short Note on Daniel 5 and the “Finger of God” Imagery in Luke 11:20
Authors: Hom Mary Katherine , McClure Patrick 
Published: March 2018

Abstract
The “finger of God” allusion in Luke 11:20 is usually recognized to draw from explicit ot occurrences of the phrase, particularly those in Exod 8:15 mt and Deut 9:10. While not denying the influence of those passages, this article aims to explore and elucidate the unique, but oft-neglected contribution of Dan 5 to Luke 11 by way of “finger of God” imagery.
Johannine Bishops?
Authors: Byers Andrew J. 
Published: March 2018

Abstract
Though the Gospel and Letters of John are widely understood as textual embodiments of an insular, “low church” community resistant to leadership structures, the later episcopal ecclesiology of Ignatius of Antioch is actually compatible with Johannine theology. Ignatius envisions the office of bishop as deriving from participatory reciprocity, an ecclesial dynamic demonstrated in the fourth evangelist’s narrative portraits of the disciples collectively and individually of Peter and the Beloved Disciple. After a reconsideration of the supposed tension between these two Gospel characters, the article will briefly reassess standard interpretations of another pair of antagonists—Diotrephes and John the Elder—whose tension is regularly attributed to Johannine anti-institutionalism. Even if the traditions behind the Gospel and Epistles of John had promoted an egalitarianism disinclined toward hierarchical leadership structures, the Johannine themes of reciprocity and participation may have contributed to the episcopal models of church orders that became established in 2nd century Christianity and beyond.
Hearing Trajectory in Children with Congenital Cytomegalovirus Infection
Authors: Lanzieri Tatiana M. , Chung Winnie , Leung Jessica , Caviness A. Chantal , Baumgardner Jason L. , Blum Peggy , Bialek Stephanie R. , Demmler‐Harrison Gail ,   for the Congenital Cytomegalovirus Longitudinal Study Group
Published: March 2018

ObjectivesTo compare hearing trajectories among children with symptomatic and asymptomatic congenital cytomegalovirus infection through age 18 years and to identify brain abnormalities associated with sensorineural hearing loss (SNHL) in asymptomatic case patients.Study DesignLongitudinal prospective cohort study.SettingTertiary medical center.Subjects and MethodsThe study included 96 case patients (4 symptomatic and 92 asymptomatic) identified through hospital‐based newborn cytomegalovirus screening from 1982 to 1992 and 72 symptomatic case patients identified through referrals from 1993 to 2005. We used growth curve modeling to analyze hearing thresholds (0.5‐8 kHz) by ear with increasing age and Cox regression to determine abnormal findings on head computed tomography scan associated with SNHL (hearing threshold ≥25 dB in any audiometric frequency) among asymptomatic case patients.ResultsFifty‐six (74%) symptomatic and 20 (22%) asymptomatic case patients had SNHL: congenital/early‐onset SNHL was diagnosed in 78 (51%) and 10 (5%) ears, respectively, and delayed‐onset SNHL in 25 (17%) and 20 (11%) ears; 49 (32%) and 154 (84%) ears had normal hearing. In affected ears, all frequency‐specific hearing thresholds worsened with age. Congenital/early‐onset SNHL was significantly worse (severe‐profound range, >70 dB) than delayed‐onset SNHL (mild‐moderate range, 26‐55 db). Frequency‐specific hearing thresholds were significantly different between symptomatic and asymptomatic case patients at 0.5 to 1 kHz but not at higher frequencies (2‐8 kHz). Among asymptomatic case patients, white matter lucency was significantly associated with SNHL by age 5 years (hazard ratio, 4.4; 95% CI, 1.3‐15.6).ConclusionCongenital/early‐onset SNHL frequently resulted in severe to profound loss in symptomatic and asymptomatic case patients. White matter lucency in asymptomatic case patients was significantly associated with SNHL by age 5 years.
The Ability of Human Nasal Inferior Turbinate–Derived Mesenchymal Stem Cells to Repair Vocal Fold Injuries
Authors: Kim Choung‐Soo , Choi Hyunsu , Park Ki Cheol , Kim Sung Won , Sun Dong‐Il 
Published: March 2018

ObjectiveThis study investigated the ability of implanted human nasal inferior turbinate–derived mesenchymal stem cells (hTMSCs) to repair injured vocal folds. To this end, we used quantitative real‐time polymerase chain reaction (PCR) to analyze the early phase of wound healing and histopathological analysis to explore the late phase of wound healing in xenograft animal models.Study DesignProspective animal study.SettingResearch laboratory.Subjects and MethodsThe right‐side lamina propria of the vocal fold was injured in 20 rabbits and 30 rats. Next, hTMSCs were implanted into half of the injured vocal folds (hTMSC groups). As a control, phosphate‐buffered saline (PBS) was injected into the other half of the injured vocal folds (PBS groups). Rat vocal folds were harvested for polymerase chain reaction (PCR) at 1 week after injury. Rabbit vocal folds were evaluated endoscopically and the larynges harvested for histological and immunohistochemical examination at 2 and 8 weeks after injury.ResultsIn the hTMSC group, PCR showed that hyaluronan synthase (HAS) 1, HAS 2, and transforming growth factor (TGF)–β1 were significantly upregulated compared with the PBS group. Procollagen type III (COL III) messenger RNA expression was significantly upregulated in the PBS group compared with the normal group. Histological analyses showed that hTMSC administration afforded more favorable collagen and hyaluronic acid deposition than was evident in the controls. Implanted hTMSCs were observed in injured vocal folds 2 weeks after implantation.ConclusionsOur results show that hTMSCs implantation into injured vocal folds facilitated vocal fold regeneration, with presenting antifibrotic effects.
Acute Invasive Fungal Rhinosinusitis in Immunocompromised Patients: Role of an Early Diagnosis
Authors: Fernandez Ignacio Javier , Crocetta Francesco Maria , Demattè Marco , Farneti Paolo , Stanzani Marta , Lewis Russel E. , Fornaciari Martina , Pasquini Ernesto , Sciarretta Vittorio 
Published: March 2018

ObjectiveThe aims of the present study were to evaluate the clinical significance of the delay for surgical treatment and the prognostic value of other clinical, pathologic, and microbiological variables among hematologic patients affected by acute invasive fungal rhinosinusitis (AIFRS). Furthermore, we propose our early diagnosis and treatment protocol, reporting its 10‐year results.Study DesignMonocentric retrospective analysis.SettingThe study was conducted from 2001 to 2017 at the University Hospital of Bologna, Italy.Subjects and MethodsThe impact of time to treatment and clinical, pathologic, and microbiological variables were analyzed among patients with histologically and microbiologically proven AIFRS. The outcomes of patients treated before the introduction of the early diagnosis protocol were compared with those treated afterward.ResultsNineteen patients affected by AIFRS were eligible for the study. Treatment delay >4 days (P =. 002), infection caused by Mucorales (P =. 015), and extension of the disease were negative prognostic variables (P =. 017). The application of our protocol significantly reduced the delay for diagnosis and appropriate treatment by an average of 7.3 days (P =. 02).ConclusionThe promptness of the diagnosis and surgical treatment may play a significant role in the management of AIFRS, as it appears to be significantly associated with the disease outcome. Our protocol may help to reduce the time required for diagnosis of high‐risk hematologic patients.
Heavy metal contamination in soils and vegetables and health risk assessment of inhabitants in Daye, China
Authors: Yang Jun , Ma Silu , Zhou Jingcheng , Song Yongwei , Li Fei 
Published: March 2018

Objective This study was performed to evaluate the state of heavy metal contamination in soil and vegetables and assess the health risk of inhabitants in the mine-affected area and area far from the mine (reference area) in Daye, China. Methods The heavy metal concentrations in soil and vegetable samples were detected by inductively coupled plasma mass spectrometry. Residents’ exposure parameters were obtained through a questionnaire survey. A health risk assessment model recommended by the United States Environmental Protection Agency was used to evaluate the residents’ risk of oral exposure. Results The copper, lead, cadmium, and arsenic concentrations in soil and in vegetables were higher in the mine-affected area than in the reference area. The health risk of residents in the reference area was within the acceptable range (hazard index < 1, carcinogen risk < 10−4). In the contaminated area, however, the mean hazard index was 2.25 for children and 3.00 for adults, and the mean carcinogen risk was 4.749 × 10−4 for children and 0.587 × 10−4 for adults. Conclusions Potential health risks exist for inhabitants near the mine area. Cadmium and arsenic should be paid more attention as risk sources.
Short course of simvastatin has no effect on markers of endothelial activation in normolipidemic patients with systemic sclerosis
Authors: Kotyla Przemyslaw J. 
Published: March 2018

Objective Statins, a class of 3-hydroxy-3 methyl-glutaryl-coenzyme A reductase inhibitors, are widely used for the treatment of atherosclerosis. Less is known about the role of statins in the treatment of vascular complication in systemic sclerosis (SSc). We therefore performed a short-term interventional study with simvastatin in patients with the diffuse variant of SSc and normal lipid profiles. Methods Twenty-five patients with diffuse SSc were enrolled and received simvastatin at a daily dose of 20 mg for 28 days. Soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble P-, E- and L-selectins were assessed by ELISA prior to treatment and at day 28. Results No statistically significant changes in the levels of adhesion molecules were observed: sICAM-1 1011 vs. 1032 ng/mL, sVCAM-1 1225 vs. 1570 ng/mL, sP-selectin 66.7 vs. 66.0 ng/mL, sE-selectin 276 vs. 253 ng/mL and sL-selectin 887 vs. 927 ng/mL prior to treatment and at day 28, respectively. Conclusions Markers characterizing vascular activation were not affected by short treatment with low-dose simvastatin in SSc patients, indicating that the endothelial-protective effect of statins may be related to treatment duration and dose.
Long-term Follow up in Chronic Hemofiltration
Authors: Quellhorst E. 
Published: March 2018

The course of treatment is demonstrated in 72 patients with chronic renal insufficiency who were undergoing regular hemofiltration for more than 6 months. 29 patients were treated for more than 5 years and 8 for more than 6 years with hemofiltration exclusively, total experience comprising 2,985 patient months. Thus, 16% of all patients accepted for artificial kidney treatment were selected for this form of therapy. Main reasons for transfer from hemodialysis to hemofiltration were hypotension, hypertension and/or repeated episodes of overhydration. In 12 patients with severe drug- and dialysis-resistant hypertension, blood pressure was normalized within 6 weeks after transfer to hemofiltration. Whereas some parameters of lipid and bone metabolism showed a tendency towards normalization, a favourable effect of hemofiltration on neuropathy was not observed. Main causes of death were encephalomalacia and cardiac infarction. Contraindications for post-dilution hemofiltration are vascular access problems resulting in a reduced blood flow and severe catabolism with accumulation of low molecular protein metabolities or potassium.
Technical and Clinical Aspects of Cascade Filtration Plasma Exchange (CFPE)
Authors: Quaranta J.F. , Cassuto-Viguier E. , Maiolini R. , Sanderson F. , Duplay H. 
Published: March 2018

Cascade filtration plasma exchanges (CFPE) were realized using an hemofiltration system (HFS) coupled to 2 filters with different pore sizes. The first one (F1 = plasma-separator; Asahi plasmaflo HI-05) separates plasma from whole blood, the second one (F2 = plasma filter; Asahi XK-60, Kuraray EVAL 2A or 4A) filtrates high molecular weight (MW) components from the separated plasma. F2 filtrate returns to patient mixed with blood cells and 4% Albumin solution or Plasmion R* replacing plasma discarded (about 0.5-0.8 I for 1-1.5 plasma mass (PM) treated). The HFS is able i) to modulate the different pressures (veinous pressure, F1 and F2 transmembrane pressures (TMp)) using pumps speed variators, ii) to recirculate and concentrate extracted plasma and iii) to know F2 treated PM. Blood pressure, pulse rate and electrocardiogram were monitored during each CFPE session. Nineteen CFPE were performed for 8 patients selected among our PE indications, this selection taking into account presence or not of risk factors linked to disease e and/or to patient. Anti-histamine drugs were always infused before CFPE session. On a biological point of view, the problem lies into F2 selectivity which is relatively good for low (as Albumin) and high (as IgM) MW molecules which are returned to patient or discarded, but should be improved for the intermediate ones (as IgG). On a technical point of view, the plasma substitute quantity is reduced about six times. But the control of F2 TMp is not perfectly and the PM to be treated has to be investigated. On a clinical point of view and through biological results, diseases with high MW mediators may benefit of CFPE. Anyway, CFPE should be improved for IgG mediated diseases.
Regulatory avoidance in the temporary work agency industry: Evidence from Australia
Authors: Knox Angela 
Published: March 2018

AbstractWithin the context of the Australian Senate’s Inquiry into corporate avoidance of the Fair Work Act 2009, this research examines regulatory avoidance in the temporary work agency industry. The findings highlight that regulatory avoidance in Australian temporary work agencies has intensified and expanded, normalising exploitation and further exacerbating precarious work and its detrimental outcomes. The study contributes to debates regarding regulation of temporary work agencies and illustrates the importance of examining how regulatory avoidance is constructed and played out in national contexts.
An International Effort to Develop a Fidelity Measure for Signs of Safety®
Authors: Roberts Yvonne Humenay , Caslor Michael , Turnell Andrew , Pearson Kim , Pecora Peter J. 
Published: March 2018

Purpose: This article describes how a worker fidelity assessment measure was developed for Signs of Safety®—an approach to assessing safety and risk in child protective services that is being implemented in the United States and over 11 other countries. Methods: We applied the Delphi Survey process with 70 experts from nine countries to identify key practice elements that could be assessed by supervisors. Then, 435 frontline staff were assessed by 285 supervisors from six countries. Results: Factor analyses of the 28 items yielded four distinct factors. These data were then used to refine the fidelity assessment. Discussion: The majority of supervisors reported that the assessment helped them to identify worker strengths and areas for refinement within the dimensions of Signs of Safety and overall child protective services practice. The value of developing similar tools for parents and workers was endorsed by the study participants.
A Quasi-Trial Investigation of an In-Service Training to Improve Social Workers’ Professional Competence in China
Authors: Zhang Huan , Wang Yean , Liu Ziyu , Chui Ernest Wing-tak 
Published: March 2018

Objective: This study examines the impact of the PC 3-sessions Training Project (PC-project), designed to improve professional competency among social workers in China. Methods: Using a quasi-experimental approach, 170 social workers from social work organizations (SWOs) or community organizations (COs) participated. The experimental group (Group 1), with 127 members, participated in all three sessions; comparison Group 2, with 22 participants, attended the last two sessions; and comparison Group 3, with 21 individuals, participated in the third session. Results: Those who participated in all three sessions improved in four dimensions of professional competency: teamwork skills, community work skills, case management skills, and supportive skills, while the comparison groups showed no significant improvement. In addition, social workers in COs developed their professional competency in more dimensions than those in SWOs. Conclusions: The PC-project is effective in improving social workers’ professional competencies; hence, this program should be used in China for training and continuous development.