bluuebunny/crossref_metadata_2025_split huggingface dataset:
From sūtra to practice: discovering the liturgy of the seven Tathāgatas including Bhaiṣajyaguru in Old Tibetan manuscripts
Authors: Hu Enbo 
Published: November 2024

Abstract
This paper focuses on a group of Old Tibetan manuscripts from Dunhuang that are currently in the Stein and Pelliot Collections, some of which will be reordered and reunited. These texts were previously believed to concern the offering to the seven Tathāgatas or the texts about the former aspirations of the seven Buddhas. However, as my study shows, they actually pertain to liturgies for the seven Tathāgatas including Bhaiṣajyaguru. Based on earlier studies, this research seeks to establish a stronger connection between “pre-canonical” texts and canonical works in Tibetan and Chinese, and to establish a hitherto unknown link in the chain of the textual transmission of this liturgy. After revealing the structure of the liturgy, it seeks to fill the gap between the Bhaiṣajyaguru-sūtra itself and the religious practices of worshipping the seven Tathāgatas including Bhaiṣajyaguru. These are done through a two-dimensional textual analysis, i.e.: 1) identifying the connection between the Old Tibetan materials and the Tibetan canonical version; and 2) analysing the process of the liturgicalization of the sūtra.
The impact of internal and external factors across language domains and features in sequential bilingual acquisition
Authors: Logue Susan , Sevdali Christina , Folli Raffaella , Gerard Juliana 
Published: November 2024

Abstract
Factors which impact bilingual language development can often interact with different language features. The current study teases apart the impact of internal and external factors (chronological age, length of exposure, L2 richness, L2 use at home, maternal education and maternal L2 proficiency) across linguistic domains and features (vocabulary, morphology and syntax). Participants were 40 Arabic-speaking sequential bilinguals acquiring English (5;7-12;2, M = 8;4). Length of exposure predicted vocabulary and morphology, while chronological age predicted syntax. L2 richness also predicted vocabulary and syntax, although the impact on syntax was selective across structures. This split between syntax on the one hand, and vocabulary and morphology on the other, reflects the more embedded properties of the former; this contrasts with vocabulary and morphology, where transfer from the L1 and L2 may be more strongly dependent on the availability of shared forms across languages. Further implications are considered for sequential bilinguals in education contexts.
‘A World Coming Back’: Operetta on Early Italian Television
Authors: Senici Emanuele 
Published: November 2024

Abstract
Between October 1954 and May 1955 RAI, the Italian public broadcaster, transmitted its first operetta season on television, promoted by Radiocorriere, the RAI house weekly, in terms of ‘a world coming back’. Yet this comeback did not have the lasting impact that was evidently desired: Italian television would never again pay such close attention to operetta, and the 1954–5 ‘operetta season’ remains an intriguing one-off. This neglected encounter between mass media and music in twentieth-century Italy has rich historiographical potential, which the article explores. Among other issues, studying the 1954–5 RAI operetta season helps us better understand not only the deep connections between postwar Italian culture and its fascist past – still a contentious matter – but also the complex discursive, technological and affective interactions between a mass medium tirelessly promoted as new and a form of popular entertainment that was already perceived as hopelessly out of date.
Impact of growth on electrophysiological properties of ventricular pre-excitation in paediatric athletes
Authors: Raimondo Cristina , Flore Francesco , Alberio Antonino Maria Quintilio , Garibaldi Silvia , Campisi Marta , Tamburri Ilaria , Drago Fabrizio 
Published: November 2024

AbstractAim:Risk stratification is recommended for patients with ventricular pre-excitation, particularly when sports eligibility is required. Few studies have examined the changes in the electrophysiological properties of the accessory pathway during growth. This study investigates the evolution of electrophysiological properties of the ventricular pre-excitation in young athletes referred for sports eligibility.Methods:Between January 2011 and July 2022, 44 paediatric patients (32 males; mean age, 10 ± 2.42) with ventricular pre-excitation underwent an electrophysiological study, both at rest and during adrenergic stress at two different times (T0 and T1) within a minimal interval of 2 years. Transcatheter ablation was not performed between the two electrophysiological studies. Electrophysiological data were collected and compared.Results:Electrophysiological study under basal conditions showed a significant decrease in the anterograde accessory pathway effective refractory period and 1:1 conduction over the accessory pathway from T0 to T1. The shortest pre-excited R-R interval during atrial fibrillation did not significantly change at the basal condition; however, it decreased during the stress test. Furthermore, six patients (13.6%) changed the risk profile of their accessory pathway: two “high-risk” patients at T0 became “low-risk” and four “low-risk” patients became “high-risk” at T1. Atrioventricular re-entry tachycardia inducibility did not differ significantly between the two electrophysiological studies.Conclusions:This study highlights the importance of repeating electrophysiological study (transesophageal or intracardiac) in paediatric athletes with ventricular pre-excitation because significant and clinically relevant changes in the conduction and refractoriness of accessory pathway can occur. This could influence risk stratification for sports eligibility and the correct indication and timing for accessory pathway ablation.
The long-term vascular and myocardial outcomes in selected Kawasaki disease patients with regression of giant coronary artery aneurysms
Authors: Kung Samuel C. , Miyata Koichi , Colvert Gabrielle M. , Kahn Andrew M. , Daniels Lori B. , Hoshino Shinsuke , Dummer Kirsten B. , Golding Ian Fraser , Roberts Samantha , Shimizu Chisato , Tremoulet Adriana H. , McVeigh Elliot R. , Gordon John B. , Burns Jane C. 
Published: November 2024

AbstractBackground:Giant coronary artery aneurysms and myocardial fibrosis after Kawasaki disease may lead to devastating cardiovascular outcomes. We characterised the vascular and myocardial outcomes in five selected Kawasaki disease patients with a history of giant coronary artery aneurysms that completely regressed.Methods:Five patients were selected who had giant coronary artery aneurysm in early childhood that regressed when studied 12–33 years after Kawasaki disease onset. Coronary arteries were imaged by coronary CT angiography, and coronary artery calcium volume scores were determined. We used endocardial strain measurements from CT imaging to assess myocardial regional wall function. Calprotectin and galectin-3 (gal-3) as biomarkers of inflammation and myocardial fibrosis were measured by enzyme-linked immunosorbent assay.Results:The five selected patients with regressed giant coronary artery aneurysms had calcium scores of zero, normal levels of calprotectin and gal-3, and normal appearance of the coronary arteries by coronary computed tomography angiography. CT strain demonstrated normal peak systolic and diastolic strain patterns in four of five patients. In one patient with a myocardial infarction at the time of Kawasaki disease diagnosis at the age of 10 months, CT strain showed altered global longitudinal strain, reduced segmental peak strain, and reduced diastolic relaxation patterns in multiple left ventricle segments.Conclusions:These patients illustrate that regression of giant aneurysms after Kawasaki disease is possible with no detectable calcium, normal biomarkers of inflammation and fibrosis, and normal myocardial function. Individuals with regressed giant coronary artery aneurysm still require longitudinal surveillance to assess the durability of this favourable outcome.
Balloon angioplasty for bilateral severe peripheral pulmonary artery stenoses associated with chondrodysplasia punctata: a case report
Authors: Go Kiyotaka , Yasuda Kazushi , Kato Taichi 
Published: November 2024

AbstractWe present a 2-month-old girl with chondrodysplasia punctata in whom bilateral peripheral pulmonary artery stenoses were successfully treated by transcatheter balloon angioplasty. The minimal diameters of the right and left pulmonary arteries of 1.3 mm and 1.1 mm, respectively, which were dilated using a 4-mm balloon catheter. Balloon angioplasty is feasible and effective for relieving peripheral pulmonary artery stenosis in patients with chondrodysplasia punctata.
The historical opposition to psychedelic research and implications for credibility in psychiatry
Authors: Koning Elena , Chu Elvina M. , Brietzke Elisa 
Published: November 2024

AbstractPsychedelics are a group of psychoactive substances that alter consciousness and produce marked shifts in sensory perception, cognition, and mood. Although psychedelics have been used by indigenous communities for centuries, they have only recently been investigated as an adjunctive therapeutic tool in psychotherapy. Since the early twentieth century, psychedelic-assisted psychotherapy has been explored for the treatment of several neuropsychiatric conditions characterized by rigid thought patterns and treatment resistance. However, this rapidly emerging field of neuroscience has evolved alongside opposition in several areas, including the affiliation with mid-twentieth century counterculture movements, media sensationalization, legislative restriction, and scientific criticisms such as “breaking the blind” and “excessive enthusiasm.” This perspective article explores the historical opposition to psychedelic research and the implications for the credibility of the field. In the midst of psychedelic drug policy reform, drawing lessons from historical events will contribute to clinical research efforts in psychiatry.
Visual release hallucinations presenting as psychosis – a scoping review
Authors: Bonomo Nicholas , Schoenbachler Ben , Lippmann Steven 
Published: November 2024

AbstractObjectiveVisual release hallucinations are perceptual disturbances that occur in individuals who have experienced vision loss. Almost 50 million people worldwide are believed to experience visual release hallucinations, yet they are profoundly underdiagnosed. Although first described within the Charles Bonnet syndrome, the paradigm underlying this syndrome precludes their consideration in many populations, such as those with underlying psychiatric illness or dementia. Consequently, visual release hallucinations have rarely been studied in patients presenting with psychosis. We conducted a scoping review to determine whether visual-release hallucinations occur in psychotic patients.MethodsThe PubMed research database was searched from inception through April 2023. Cases were collected reporting on psychotic patients experiencing suspected visual release hallucinations. Individual treatment courses and responses were extracted.ResultsThirteen cases compiled from 11 different studies were summarized to provide baseline characteristics and overall trends in treatment response. Most patients did not remit from pharmacological management alone. All patients who received reafferentation therapy remitted, though many were not candidates. Almost half of the patients did not achieve remission.ConclusionsVisual release hallucinations can manifest in psychosis and may contribute to treatment-resistant psychosis among psychiatric populations. A shift in our understanding of visual release hallucinations may aid their recognition in psychotic patients by shifting the focus toward visual release features. Recognizing release features among patients with hallucinatory conditions may open new treatment avenues for managing patients with psychosis. A preliminary screening index for visual release features is provided to support this shift.
Property-Based Testing by Elaborating Proof Outlines
Authors: MILLER DALE , MOMIGLIANO ALBERTO 
Published: November 2024

AbstractProperty-based testing (PBT) is a technique for validating code against an executable specification by automatically generating test-data. We present a proof-theoretical reconstruction of this style of testing for relational specifications and employ the Foundational Proof Certificate framework to describe test generators. We do this by encoding certain kinds of “proof outlines” as proof certificates that can describe various common generation strategies in the PBT literature, ranging from random to exhaustive, including their combination. We also address the shrinking of counterexamples as a first step toward their explanation. Once generation is accomplished, the testing phase is a standard logic programing search. After illustrating our techniques on simple, first-order (algebraic) data structures, we lift it to data structures containing bindings by using the
$\lambda$
-tree syntax approach to encode bindings. The
$\lambda$
Prolog programing language can perform both generating and checking of tests using this approach to syntax. We then further extend PBT to specifications in a fragment of linear logic.
A Toy Model for the Global Annual Number of Tropical Cyclones
Authors: Zhou Yufeng , Lin Yanluan 
Published: November 2024

AbstractThe annual number of global tropical cyclones (TCs) has remained rather stable at ∼90 in the past decades, yet the underlying physics and mechanisms remain elusive. This study utilizes observational data to assess TC‐environment interactions, such as atmospheric drying, stabilization, and oceanic cooling, which occur after TC passage and inhibit subsequent TC formation. Focused on the recovery of TC‐induced hostile environment, we construct an idealized toy model incorporating the global main development region (MDR), recovery time and influencing radius. The model well captures the spatial and temporal characteristics of TC activity. Then we propose a new scaling of annual TC number, framed as a spatiotemporal packing problem determined by the total spatiotemporal area available for TC formation and the average area occupied by each TC. The recovery time is included as a new temporal constraint, and this scaling is validated by toy model simulations and offers insights into observations. Specifically, based on TC attributes in the current climate, the scaling yields an estimate of ∼100 TCs per year given a recovery time of 2–3 weeks. It also implies that a warming climate might lead to fewer TCs due to increased TC size and longer recovery times.
Lightning‐Fast Convective Outlooks: Predicting Severe Convective Environments With Global AI‐Based Weather Models
Authors: Feldmann Monika , Beucler Tom , Gomez Milton , Martius Olivia 
Published: November 2024

AbstractSevere convective storms are among the most dangerous weather phenomena and accurate forecasts mitigate their impacts. The recently released suite of AI‐based weather models produces medium‐range forecasts within seconds, with a skill similar to state‐of‐the‐art operational forecasts for variables on single levels. However, predicting severe thunderstorm environments requires accurate combinations of dynamic and thermodynamic variables and the vertical structure of the atmosphere. Advancing the assessment of AI‐models toward process‐based evaluations lays the foundation for hazard‐driven applications. We assess the forecast skill of the top‐performing AI‐models GraphCast, Pangu‐Weather and FourCastNet for convective parameters at lead‐times up to 10 days against reanalysis and ECMWF's operational numerical weather prediction model IFS. In a case study and seasonal analyses, we see the best performance by GraphCast and Pangu‐Weather: these models match or even exceed the performance of IFS for instability and shear. This opens opportunities for fast and inexpensive predictions of severe weather environments.
The Excitation of Second Harmonic Poloidal ULF Waves Through Drift‐Bounce Resonance With Protons in the Magnetic Dip
Authors: Zhuang Yan , Yue Chao , Li Li , Zhou Xu‐Zhi , Zong Qiu‐Gang , Wang Shan , Liu Ying , Li Xing‐Yu , Yin Ze‐Fan , Wang Yong‐Fu , Liu Zhi‐Yang , Fu Haobo 
Published: November 2024

AbstractThe drift‐bounce resonance between ultralow‐frequency (ULF) waves and charged particles is an efficient way to transfer energy. In this study, we report the excitation of ULF waves through drift‐bounce resonance with protons in the magnetic dip for the first time. On 4 September 2015, Van Allen probe B observed ULF signals with a frequency of ∼10 mHz inside the magnetic dip during substorms at the dusk side. The ULF waves are further diagnosed as second harmonic poloidal waves. The 54–67 keV protons in the magnetic dip exhibit oscillations with the same period as ULF waves, providing evidence for drift‐bounce resonance. Through finite Larmor radius effects, we determined that the ULF waves propagate eastward with an azimuthal wave number in the range of 237–277. The ULF waves are excited with free energy related to the enhanced proton phase space density in the magnetic dip.
A Novel 3‐D Seismic Scattering and Intrinsic Attenuation Tomography and Its Application to Northern Sumatra
Authors: Wei Jia , Liu Qiancheng , Chen Ling , Wei Shengji , Zhao Liang 
Published: November 2024

AbstractStudying the subsurface structure of volcanoes is crucial for understanding volcanic mechanisms, current status, and potential risks. However, the intricate physical and chemical processes occurring over geological timescales make it challenging to characterize subsurface features such as volcanic structures and hydrothermal systems. Given the highly attenuating nature of magma, 3‐D scattering and intrinsic attenuation tomography are critical methods for advancing our understanding of tectonic, magmatic, and hydrothermal processes and their interactions. Previous imaging techniques, however, required substantial memory usage and long computational times, limiting their application to only 1‐D velocity models. This paper proposes a novel sensitivity‐kernel calculation method for imaging shear wave seismic scattering and intrinsic attenuation. This method has the advantages of dramatically reducing memory and computational costs, as well as incorporating a 3‐D seismic velocity model. We apply this approach to illustrate the 3‐D scattering and intrinsic attenuation structures beneath the Toba volcano region in Northern Sumatra down to 20 km depth. Our results show high‐intrinsic attenuation anomalies around the Toba caldera, revealing the magma chambers feeding the volcanoes. A conspicuous high‐scattering attenuation anomaly is identified along the Great Sumatran Fault, possibly caused by the fault zone structure. Magmatism also likely contributes to the seismic activity south of the Toba caldera, as evidenced by the overlap of scattering and intrinsic attenuation anomalies.
The Influence of Using a Seismically Inferred Magma Reservoir Geometry in a Volcano Deformation Model for Soufrière Hills Volcano, Montserrat
Authors: Dibben J. , Hickey J. , Pascal K. , Paulatto M. 
Published: November 2024

AbstractVolcano deformation models contribute to hazard assessment by simulating magma system dynamics. Traditional magma reservoir pressure source shape assumptions often fail to replicate irregular, geophysically identified geometries. Uncertainties regarding the influence of reservoir geometry can limit the effectiveness of using deformation models to decipher unrest signals. Here, we aim to determine the feasibility of using a magma reservoir geometry directly derived from a seismic tomography survey in a volcano deformation model for Soufrière Hills Volcano, Montserrat. Three‐dimensional deformation models are created to simulate displacement using a pressure source geometry constrained from a low seismic velocity anomaly, inferred to be a region of partial melt, and contrasted against a traditional ellipsoid reservoir geometry. We also test a “hybrid” model combining a seismically inferred reservoir upper geometry and ellipsoidal base. Results of each model are evaluated against ground displacement observed on Montserrat from 2010 to 2022. Our results show that different reservoir geometries change the horizontal and vertical displacement fields across the island: the ellipsoid reservoir best reproduces vertical displacement magnitude, while the hybrid reservoirs best simulate horizontal displacement vectors and the region of maximum uplift. Overall, the ellipsoid‐shaped reservoir provides our best‐fit to the observed data, but we note this result could be biased due to prior years of optimization helping constrain the ellipsoid shape, size, and location. Our results show the potential for further use of geophysically constrained reservoir geometries in deformation modeling, and our methods could be applied to other deforming volcanoes worldwide.
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression
Authors: Wu Ouqiang , Jin Yuxin , Zhang Zhiguang , Zhou Hao , Xu Wenbin , Chen Linjie , Jones Morgan , Kwan Kenny Yat Hong , Gao Jianyuan , Zhang Kai , Cheng Xiaofei , Chen Qizhu , Wang Xinzhou , Li Yan Michael , Guo Zhenyu , Sun Jing , Chen Zhihua , Wang Bin , Wang Xiangyang , Shen Shuying , Wu Aimin 
Published: November 2024

AbstractIntervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses. However, the specific mechanisms that regulate the senescence of NPCs remain unknown. In this study, we observed impaired autophagy in IVDD-NPCs, which contributed to the upregulation of NPCs senescence and the senescence-associated secretory phenotype (SASP). The dysregulated SASP disrupted NPCs viability and initiated extracellular matrix degradation. Conversely, the restoration of autophagy reversed the senescence phenotype by inhibiting GATA binding protein 4 (GATA4). Moreover, we made the novel observation that a cross-talk between histone H3 lysine 4 trimethylation (H3K4me3) modification and N6-methyladenosine(m6A)-methylated modification regulates autophagy in IVDD-NPCs. Mechanistically, lysine methyltransferase 2A (KMT2A) promoted the expression of methyltransferase-like 3 (METTL3) through H3K4me3 modification, whereas METTL3-mediated m6A modification reduced the expression of autophagy-associated 4a (ATG4a) by attenuating its RNA stability, leading to autophagy damage in NPCs. Silencing KMT2A and METTL3 enhanced autophagic flux and suppressed SASP expression in IVDD-NPCs. Therefore, targeting the H3K4me3-regulated METTL3/ATG4a/GATA4 axis may represent a promising new therapeutic strategy for IVDD.
Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Authors: Krivec Nuša , Couvreu de Deckersberg Edouard , Lei Yingnan , Al Delbany Diana , Regin Marius , Verhulst Stefaan , van Grunsven Leo A. , Sermon Karen , Spits Claudia 
Published: November 2024

Abstract
Gain of 1q is a highly recurrent chromosomal abnormality in human pluripotent stem cells. In this work, we show that gains of 1q impact the differentiation capacity to derivates of the three germ layers, leading to mis-specification to cranial placode and non-neural ectoderm during neuroectoderm differentiation. Also, we found a weaker expression of lineage-specific markers in hepatoblasts and cardiac progenitors. Competition assays show that the cells retain their selective advantage during differentiation, which is mediated by a higher expression of MDM4, a gene located in the common region of gain. MDM4 drives the winner phenotype of the mutant cells in both the undifferentiated and differentiating state by reducing the cells’ sensitivity to DNA damage through decreased p53-mediated apoptosis. Finally, we found that cell density in culture plays a key role in promoting the competitive advantage of the cells by increasing DNA damage.