bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost differences between digital tomosynthesis and standard digital mammography in a breast cancer screening programme: results from the To-Be trial in Norway
Authors: Moger Tron Anders , Swanson Jayson O. , Holen Åsne Sørlien , Hanestad Berit , Hofvind Solveig 
Published: August 2019

Abstract
Background
Several studies in Europe and the US have shown promising results favouring digital breast tomosynthesis compared to standard digital mammography (DM). However, the costs of implementing the technology in screening programmes are not yet known.

Methods
A randomised controlled trial comparing the results from digital breast tomosynthesis including synthetic mammograms (DBT) vs. DM was performed in Bergen during 2016 and 2017 as a part of BreastScreen Norway. The trial included 29,453 women and allowed for a detailed comparison of procedure use and screening, recall and treatment costs estimated at the individual level.

Results
The increased cost of equipment, examination and reading time with DBT vs. DM was €8.5 per screened woman (95% CI 8.4−8.6). Costs of DBT remained significantly higher after adding recall assessment costs, €6.2 (95% CI 4.6−7.9). Substantial reductions in either examination and reading times, price of DBT equipment or price of IT storage and connectivity did not change the conclusion. Adding treatment costs resulted in too wide confidence intervals to draw definitive conclusions (additional costs of tomosynthesis €9.8, 95% CI –56 to 74). Performing biopsy at recall, radiation therapy and chemotherapy was significantly more frequent among women screened with DBT.

Conclusion
The results showed lower incremental costs of DBT vs. DM, compared to what is found in previous cost analyses of DBT and DM. However, the incremental costs were still higher for DBT compared with DM after including recall costs. Further studies with long-term treatment data are needed to understand the complete costs of implementing DBT in screening.
Revisiting the combinatorics of lifting line and 2D vortex lattice theory
Authors: Yukish M. A. 
Published: August 2019

ABSTRACTThis work revisits analyses of lifting line theory by A.R. Collar from 1958, bringing to bear some modern tools and techniques. The 2D vortex lattice model is also considered. Interesting combinatorial properties and simplified expressions for terms are presented, a simplified proof of model convergence shown, extension of the convergence properties to elliptical and arbitrary wing planforms is demonstrated, and approximations provided. An alternative proof of the optimality of constant downwash is presented. Modern automated theorem proving techniques are employed in confirming the combinatorial results.
Impact of Clinician Personal Protective Equipment on Medical Device Use During Public Health Emergency: A Review
Authors: Wiyor Hanniebey D. , Coburn James C. , Siegel Karen L. 
Published: August 2019

ABSTRACTThe aim of this systematic review is to evaluate the impact of personal protective equipment (PPE) on medical device use during public health emergency responses. We conducted a systematic literature search of peer-reviewed journals in PubMed, Web of Science, and EBSCO databases. Twenty-nine of 92 articles published between 1984 and 2015 met the inclusion criteria for the review. Although many medical device use impacts were reported, they predominantly fell into 3 categories: airway management, drug administration, and diagnostics and monitoring. Chemical, biological, radiological, and nuclear (CBRN)-PPE increased completion times for emergency clinical procedures by as much as 130% and first attempt failure rates by 35% (anesthetist) versus 55% (non-anesthetist). Effects of CBRN-PPE use depend on device, CBRN-PPE level, and clinician experience and training. Continuous clinical training of responders in CBRN-PPE and device modifications can improve safety and effectiveness of medical device use during public health emergency response.
Fungal pathogens and arbuscular mycorrhizal fungi of abandoned agricultural fields: potential limits to restoration
Authors: Hilbig Bridget E. , Allen Edith B. 
Published: August 2019

AbstractLittle is known about impacts of soilborne pathogen legacies on reestablishment of native plant species in abandoned agricultural fields. We tested whether pathogens found in abandoned citrus orchards affect growth of native and invasive plant species in a controlled greenhouse experiment. In previous research, we identified several species of ascomycete (Fusariumspp.) and oomycete (Pythiumspp.) pathogens from field roots and soils. The invasive annual grass, ripgut brome [Bromus diandrus(Roth.)], and native forbs, common fiddleneck [Amsinckia intermediaFisch. &amp; C.A. Mey.], coastal tidytips [Layia platyglossa(Fisch. &amp; C.A. Mey.) A. Gray], and California goldfields [Lasthenia californica(DC. ex Lindl.)], were grown together in four different field soil treatments. Using pesticides on soils collected from abandoned citrus fields, we created four soil treatments that excluded different groups of potential pathogens: (1) untreated control (2) metalaxyl (oomyceticide) (3) fludioxonil (fungicide), and (4) steam-sterilized. Fludioxonil increased aboveground biomass ofL. platyglossa(P = 0.005) andL. californica(P= 0.02) compared with sterile and metalaxyl-treated soils.Lasthenia californicahad decreased arbuscular mycorrhizal colonization with metalaxyl, suggesting metalaxyl has non-target effects on mycorrhizae. Fludioxonil decreased potential pathogens inL. californicaroots while having no effect on mycorrhizal colonization.Bromus diandrushad higher biomass in sterile and fludioxonil-treated soils than untreated soils (P = 0.0001), suggesting a release from soilborne pathogens. The release from soilborne pathogens with the use of fludioxonil in both native forbs andB. diandrus, combined with overall higher biomass across treatments inB. diandrus, suggests that pathogen impacts in a field setting are insufficient to reduce success of this invasive grass, and use of a fungicide would not benefit native species in mixed stands withB. diandrus.
Linear Hydrodynamic Stability of Fluid Flow in Curved Rectangular Ducts: Semi-Analytical Study
Authors: Nowruzi H. , Ghassemi H. , Nourazar S. S. 
Published: August 2019

ABSTRACTIn the current study, for the first time, a semi-analytical technique is used for solving eigenvalue problem arising from linear hydrodynamics stability of fluid flow through the curved rectangular ducts at different curvature ratios and aspect ratios. To this accomplishment, symmetric disturbances are assumed and the Homotopy perturbation method (HPM) is applied to solve our eigenvalue problem for curvature ratios ranging from 0.01 to 0.8 and aspect ratios ranging from 0.05 to 20. Our semi-analytical results are validated through the existing numerical and experimental data, showing good agreement. The semi-analytical results indicate that, as the curvature ratio increases the critical Dean number (Dnc) is increased and the flow becomes more stable, especially for aspect ratios lower than 1.Moreover, for all intended curvature ratios, irregular behavior in variation of Dnc is detected by an increase in the aspect ratio. So that, the Dnc is decreased when the aspect ratio increases from 0.05 up to 1 and the fluid flow becomes unstable. When the aspect ratio is increased from 1 to 5, it causes to increase the Dnc and fluid flow becomes stable. Furthermore, when the aspect ratio increases from 5 to 20, the Dnc is decreased again. In addition, Dnc and eigenvalues of critical complex wave number corresponding to Dnc for the onset of Dean flow instability is reported under different curvature ratios and aspect ratios.
Differences in resistance against osmotic challenge among C57BL/6, DBA/2 and their hybrid mice metaphase II (MII) stage oocytes
Authors: Goto Mei , Saito Hirokatsu , Hiradate Yuki , Hara Kenshiro , Tanemura Kentaro 
Published: August 2019

SummaryOocytes of B6D2F1 (BDF1) mice are often used as recipients for intracytoplasmic sperm injection because of their cell membrane resistance against capillary penetration. It is assumed that oocytes of BDF1 mice have superior traits because of their hybrid vigour. However, the mechanisms of hybrid vigour are unclear. In this study, we focused on the membrane resistance of MII stage oocytes against changes in extracellular osmotic pressure. As a result, MII stage oocytes of inbred C57BL/6 and DBA/2 mice showed high tolerance in either a hypertonic or a hypotonic environment. Conversely, MII stage oocytes of hybrid BDF1 and D2B6F1 mice showed high tolerance in both hypertonic and hypotonic environments. Therefore, it is considered that MII stage oocytes of hybrid mice have superior traits than those of inbred mice. Our findings demonstrated that the hybrid vigour exists in the form of resistance to extracellular osmotic environment in hybrid MII stage oocytes.
National general truck drivers’ strike and food security in a Brazilian metropolis
Authors: Lopes Mariana Souza , Araújo Melissa Luciana de , Lopes Aline Cristine Souza 
Published: August 2019

AbstractObjective:We analysed the impact of the national general truck drivers’ strike on the availability, variety and price of foods sold by a food supply centre.Design:Descriptive study using secondary data to examine the percentage change in the mean price of fruits, vegetables and eggs before, during and after the strike. The strike in Brazil lasted 10 d from 21 to 30 May 2018. The drivers were on strike in order to make diesel oil tax-free and to obtain better working conditions.Setting:The food supply centre, named CEASA-Minas Grande BH, was located in the metropolitan area of a Brazilian city.Participants:We examined twenty types of foods.Results:After 10 d, there was a ~30 % reduction in the availability of all types of foods and prices increased. Foods with the highest price increases included cabbage (233·3 %), potatoes (220·0 %), papaya (160·0 %) and oranges (78·6 %). At the end of the strike, we observed reductions in the price of eggs, fruits, vegetables, roots and tubers; however, some foods remained more expensive than before the strike, including chayote (203·2 % higher), cucumber (66·7 % higher) and potatoes (60·0 % higher).Conclusions:The general truck drivers’ strike was correlated with a reduction in the availability of food and, consequently, increases in price and possibly restrictions on access. The strike demonstrated the dependence of metropolises on road transportation and the conventional market. We speculate that initiatives aiming to shorten the food supply chain and promote food sovereignty and resilience of the supply circuits could be important.
Demographic and socio-economic predictors of diet quality among adults in Bosnia and Herzegovina
Authors: Gicevic Selma , Gaskins Audrey J , Fung Teresa T , Rosner Bernard , Sabanovic Edin , Milesevic Jelena , Kadvan Agnes , Kremic Emir , Willett Walter 
Published: August 2019

AbstractObjective:To evaluate associations of demographic and socio-economic factors with diet quality among population subgroups in Bosnia and Herzegovina (B&H).Design:A cross-sectional analysis of 2017 B&H dietary survey data. Diet quality was assessed by the Prime Diet Quality Score (PDQS) utilizing data from two non-consecutive 24 h diet recalls. Socio-economic variables were extracted from the 2015 B&H Household Budget Survey. Homogeneity of means across population subgroups was evaluated using multivariable regression.Setting:B&H population survey.Participants:A population-based sample of 853 adults.Results:The mean PDQS was 15·8 (range 7–28 out of a possible 42 points). In general, Bosnian adults had low PDQS due to high intakes of refined grains, high-fat dairy and processed meats, and low intakes of whole grains, nuts and fish. The PDQS was significantly higher (P < 0·0001) among older individuals (17·0) compared with those in the youngest group (14·5), among individuals living in the central and northern regions (16·5) compared with those living in the south (15·1; P < 0·0001), and among people who are married/cohabitating (16·1) v. single (14·8; P = 0·02). In energy-adjusted models, socio-economic status (P = 0·04) and tertiles of household spending (P = 0·002) were inversely associated with the PDQS.Conclusions:Diet quality in this population was low. Young and middle-aged individuals, singles and those living in the south had significantly lower quality diets compared with other subgroups. Public health action is needed to promote higher consumption of whole grains, nuts and fish, and a higher variety of fruits and vegetables.
Evaluation of an in-house self-held respiration monitoring device for deep inspiration breath hold techniques for radiotherapy of patients with cancer of the left breast
Authors: Chan Yuen Yan , Ku Ki Man , Ng Yin Ping , Yu Siu Ki Ben , Kong Chi Wah Tony , Mui Wing Lun Alan , Wong Chun Man Cornel , Kong Sze Wan , Wong Sze Ming , Chiu George 
Published: August 2019

AbstractBackground:An in-house self-held respiration monitoring device (SHRMD) was developed for providing deep inspiration breath hold (DIBH) radiotherapy. The use of SHRMD is evaluated in terms of reproducibility, stability and heart dose reduction.Methods and materials:Sixteen patients receiving radiotherapy of left breast cancer were planned for treatment with both a free breathing (FB) scan and a DIBH scan. Both FB and DIBH plans were generated for comparison of the heart, left anterior descending (LAD) artery and lung dose. All patients received their treatments with DIBH using SHRMD. Megavoltage cine images were acquired during treatments for evaluating the reproducibility and stability of treatment position using SHRMD.Results:Compared with FB plans, the maximum dose to the heart by DIBH technique with SHRMD was reduced by 29·9 ± 15·6%; and the maximum dose of the LAD artery was reduced by 41·6 ± 18·3%. The inter-fractional overall mean error was 0·01 cm and the intra-fractional overall mean error was 0·04 cm.Conclusion:This study demonstrated the potential benefits of using the SHRMD for DIBH to reduce the heart and LAD dose. The patients were able to perform stable and reproducible DIBHs.
SiO2‐SiC Mixtures at High Pressures and Temperatures: Implications for Planetary Bodies Containing SiC
Authors: Daviau Kierstin , Meng Yue , Lee Kanani K. M. 
Published: August 2019

AbstractWe present results from high‐pressure and high‐temperature experiments on mixtures of SiC and SiO2 to explore the stability of SiC in the presence of oxygen‐rich silicates at planetary mantle conditions. We observe no evidence of the ambient pressure predicted oxidation products, CO or SiO, resulting from oxidation reactions between SiC and SiO2 at pressures up to ~40 GPa and temperatures up to ~2500 K. We observe the decomposition of SiC through releasing C, resulting in vacancies in the SiC lattice and consequently the contracted SiC ambient volume V0 observed in the heated regions of sample. The decomposition is further supported by the observations of diamond formation and the expanded SiO2 V0 in the heated regions of samples indicating the incorporation of C into SiO2 stishovite. We provide a new interpretation of SiC decomposition on laboratory timescales, in which kinetics prevent the reaction from reaching equilibrium. We consider how the equilibrium decomposition reaction of SiC will influence the differentiation of a SiC‐containing body on planetary timescales and find that the decomposition products may become isolated during early planetary differentiation. The resulting presence of elemental Si and C within a planetary body may have important consequences for the compositions of the mantles and atmospheres of such planets.
An Overview of Low‐Level Jet Winds and Corresponding Mixed Layer Depths During PECAN
Authors: Carroll Brian J. , Demoz Belay B. , Delgado Ruben 
Published: August 2019

AbstractThirty southerly low‐level jet (LLJ) events were observed during the Plains Elevated Convection at Night (PECAN) field campaign in the Great Plains region of the United States during summer 2015. Here we present Doppler lidar wind data from three PECAN instrumentation sites to explore characteristics of LLJs and the boundary layer as well as some of the heterogeneities possible within the wind field of a LLJ. Southerly LLJs were observed on 66% of nights at the southwestern site (Greensburg, KS) but only 56% and 53% of nights at the eastern and northern sites, respectively (Hesston and Ellis, KS). The northernmost site had a relative abundance of weaker jets or nonjet conditions due to fronts or convective systems that only affected part of the observation domain. Plotting mean wind fields of each LLJ type reveals that the strongest LLJs tend to develop under very similar conditions but begin to show variability in wind profile evolution after several hours. A robust mixed layer height retrieval algorithm is used to investigate the interplay between the jets and the turbulent convective boundary layer, showing that stronger LLJs are preceded by deeper afternoon mixed layers and often have a later decoupling of mixing between the upper convective mixed layer and the near‐surface layer. Only the strongest LLJs generated a shallow mixing layer overnight. Comparing jet strength and direction to pristine nocturnal convection initiation shows that the strongest southerly LLJs yielded the most pristine nocturnal convection initiation events per night, and the pristine nocturnal convection initiation occurred farther north.
Measurement of the combined quantum and electrochemical capacitance of a carbon nanotube
Authors: Li Jinfeng , Burke Peter J. 
Published: August 2019

AbstractThe nature of the electronic interface between a nanotube and solvated ions in a liquid electrolyte is governed by two distinct physical phenomena: quantum and chemical. The quantum component arises from the sharply varying electronic density of states and the chemical component arises from ion screening and diffusion. Here, using an integrated on-chip shield technology, we measure the capacitance of one to a few nanotubes quantitatively as a function of both bias potential (from −0.7 V to 0.3 V) and ionic concentration (from 10 mM to 1 M KCl) at room temperature. We determine the relative contributions of the quantum and electrochemical capacitance, and confirm the measurements with theoretical models. This represents an important measurement of the quantum effects on capacitance in reduced dimensional systems in contact with liquid electrolytes, an important and emerging theme in the interface between nanotechnology, energy, and life.
Doping induced Mott collapse and possible density wave instabilities in (Sr1−xLax)3Ir2O7
Authors: Wang Zhenyu , Walkup Daniel , Maximenko Yulia , Zhou Wenwen , Hogan Tom , Wang Ziqiang , Wilson Stephen D. , Madhavan Vidya 
Published: August 2019

AbstractThe path from a Mott insulating phase to high temperature superconductivity encounters a rich set of unconventional phenomena involving the insulator-to-metal transition (IMT), such as emergent electronic orders and pseudogaps, that ultimately affect the condensation of Cooper pairs. A huge hindrance to understanding the origin of these phenomena is the difficulty in accessing doping levels near the parent state. The Jeff = 1/2 Mott state of the perovskite strontium iridates has revealed intriguing parallels to the cuprates, with the advantage that it provides unique access to the Mott transition. Here, we exploit this accessibility to study the IMT and the possible nearby electronic orders in the electron-doped bilayer iridate (Sr1 − xLax)3Ir2O7. Using spectroscopic imaging scanning tunneling microscopy, we image the La dopants in the top as well as the interlayer SrO planes. Surprisingly, we find a disproportionate distribution of La between these layers with the interlayer La being primarily responsible for the IMT. This reveals the distinct site-dependent effects of dopants on the electronic properties of bilayer systems. Electron doping also results in charge reordering. We find unidirectional electronic order concomitant with the structural distortion known to exist in this system. Intriguingly, similar to the single layer iridate, we also find local resonant states forming a checkerboard-like pattern trapped by La. This suggests that multiple charge orders may exist simultaneously in Mott systems, even with only one band crossing the Fermi energy.
High mobility Si0.15Ge0.85 growth by using the molten target sputtering (MTS) within heteroepitaxy framework
Authors: Kim Hyun Jung 
Published: August 2019

AbstractHigh-speed SiGe film is promising use in photonics and electronics technologies continue to replace Si-based devices. High mobility Si0.15 Ge0.85 film on sapphire was grown at 890 °C substrate temperature by using a conventional magnetron sputtering system within the heteroepitaxy framework. 890 °C substrate temperate is impractical for commercial device manufacturing due to long thermal soak, loading time, and costly process. To leverage the practical SiGe device applications, the Molten Target Sputtering (MTS) techniques is developed. The MTS is an economic and robust process from high flux density and liquid-state of molecules benefits. At 500 °C, the lowest substrate temperature, high mobility Si0.15Ge0.85 film with continues morphology and 99.7% majority-orientation were grown by using the MTS. The hall electron mobilities of the Si0.15Ge0.85 grown at 500 °C are 456 cm2V−1s−1 and 123.9 cm2V−1s−1 at 5.59 × 1018 cm3 and 3.5 × 1020 cm3 carrier concentration at 22.38 °C, respectively. The values are 550% higher hall electron mobilities than that of Si at equivalent carrier concentration and temperatures. We envision that the MTS is beneficial for the heteroepitaxy framework film growth that requires high substrate temperature to overcome the large lattice parameter mismatch between film and substrate.
Efficient derivation of knock-out and knock-in rats using embryos obtained by in vitro fertilization
Authors: Honda Arata , Tachibana Ryoma , Hamada Kazuya , Morita Kohtaro , Mizuno Naoaki , Morita Kento , Asano Masahide 
Published: August 2019

AbstractRats are effective model animals and have contributed to the development of human medicine and basic research. However, the application of reproductive engineering techniques to rats is not as advanced compared with mice, and genome editing in rats has not been achieved using embryos obtained by in vitro fertilization (IVF). In this study, we conducted superovulation, IVF, and knock out and knock in using IVF rat embryos. We found that superovulation effectively occurred in the synchronized oestrus cycle and with anti-inhibin antiserum treatment in immature rats, including the Brown Norway rat, which is a very difficult rat strain to superovulate. Next, we collected superovulated oocytes under anaesthesia, and offspring derived from IVF embryos were obtained from all of the rat strains that we examined. When the tyrosinase gene was targeted by electroporation in these embryos, both alleles were disrupted with 100% efficiency. Furthermore, we conducted long DNA fragment knock in using adeno-associated virus and found that the knock-in litter was obtained with high efficiency (33.3–47.4%). Thus, in this study, we developed methods to allow the simple and efficient production of model rats.