bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problems with the Administration of Antipsychotic Drugs in Depot Formulations in the Treatment of Schizophrenia
Authors: Ranković Anica , Janković Slobodan 
Published: April 2018

Summary
The aim of this study was to investigate problems with the administration of antipsychotic long-acting injections (LAIs) in patients with schizophrenia. Besides many benefits, long-acting injections have been associated with a number of complications at the site of the injection.
The qualitative study included four medical workers and five patients who had been treated with fluphenazine, haloperidol, risperidone given in the form of a long-acting depot injection. The data were collected by direct observation, analysis of the history of the disease and used semi-structured interview.
Interviews completed by patients, psychiatrists and nurses were analyzed and condensed into nine key categories: Competence and training of the medical workers, Sites and technique, Registration of complications, Care of patients and privacy, Availability and evidence, Duration and frequency of treatment, Burden for the patients, The choice of formulation therapy, and Sense of stigma.
Monitoring of side-effects of LAIs was not extensive and doctors did not write adverse effects. The nurses who administered the injections were competent. Not enough attention is paid to the choice of the needle diameter and the patient was not given a choice to decide on the sites of the administraton of injection. Three out of five patients did not feel any changes at the injection site, but another patient had severe pain, redness, and induration.
The exchange of information, a possibility of choosing the site of administration, and monitoring of the effects of treatment are all positive strategies that doctors and nurses can use to help patients in the compliance to the treatment with antipsychotic long-acting injections.
Comparative Enantioseparation of Amlodipine by HPLC and Capillary Electrophoresis
Authors: Cârje Anca Gabriela , Balint Alina , Muntean Daniela-Lucia , Hancu Gabriel , Ion Valentin , Imre Silvia 
Published: April 2018

Abstract

Objective: The purpose of this study was to separate the enantiomers of amlodipine by High Performance Liquid Chromatography (HPLC) using ovomucoid (OVM) as chiral selector, respectively by Capillary Electrophoresis (CE) using cyclodextrines and to evaluate the analytical performance of the both proposed methods.

Material and methods: HPLC enantioseparation of amlodipine was performed on an HPLC Agilent Technologies 1100 series using as chiral stationary phase an Ultron ES OVM, 150x4.6 mm column with ovomucoid as chiral selector. The stereoselective CE analysis of amlodipine was achieved on Agilent Technologies 7100 CE using uncoated fused-silica capillaries 48 cm x 50 mm and different type of cyclodextrins as chiral selectors.

Results: A mobile phase consisting of 80% Na2HPO4 10 mM at a pH level of 5.0 and 20% ACN, isocratic elution at a flow of 1 ml/min turned to be the optimal experimental conditions for HPLC analysis (R=5.51; α=1.71) with retention times shorter than 10 minutes for the two isomers, tR (S-AML) = 4.63 (min); tR (R-AML) = 5.54 (min). The migration times for amlodipine enantiomers were tm (S-AML) = 8.15 (min) and tm (R-AML)= 8.45 (min) and the optimum CE conditions have proven to be a buffer solution containing 25 mM H3PO4 at pH 3.0 and 20 mM α-CD as chiral selector and a capillary temperature set at 15°C (R=1.51; α=1.03).

Conclusion: The analytical performances of the chromatographic method using OVM as chiral selector are superior to the electrophoretic analysis method but the CE method is more economical and may represent an alternative to the HPLC chromatographic separation.
Mediators of Inflammation as a Link Between Diabetes Mellitus and Periodontal Breakdown
Authors: Monea Adriana , Eremie Lia Yero , Bukhari Csilla , Beresescu Gabriela , Biris Carmen 
Published: April 2018

Abstract
Our objective was to investigate immunological changes that occur in saliva of subjects with type 2 diabetes mellitus (T2DM) without signs of periodontal disease and to establish if salivary inflammatory cytokines are a possible link between diabetes mellitus and periodontal breakdown.

Material and methods. Twenty T2DM subjects with no periodontal disease and twenty healthy controls were registered for the present study. TNF-α and IL-6 level from saliva and serum were measured. Periodontal tissue samples were histologically examined.

Results: TNF-α and IL-6 levels were higher in T2DM subjects compared to controls, with an extremely significant difference in saliva (p<0.001). Significant inflammation, affecting both epithelial and connective tissues was present in periodontal biopsies.

Conclusions: The subjects showed an increased TNF-α and IL-6 levels, both in serum and -mostly in -saliva of diabetics without signs of periodontal disease, confirming the hypothesis of immunological implication, as a correlation between periodontal disease incidence and diabetes mellitus. Histologic alterations, suggesting a local inflammatory state, were present in periodontal tissue of diabetics, confirming the above hypothesis. The study reveals that saliva analysis is a quite efficient method in testing the periodontal breakdown progression in the subjects with T2DM.
The Kinetics of the Oxidation of Lysine by μ-Peroxo-Bridged Binuclear Cobalt (III) Complex of Succinimide in Aqueous Hydrochloric Acid Medium
Authors: Adetoro Ahmed , Idris Suleiman O. , Onu Ameh D. , Okibe Friday G. 
Published: April 2018

Abstract
Kinetics of oxidation of Lysine (Lys) and mechanisms by μ-peroxo bis[bis(ethylenediamine)succinimidato-dicobalt(III)]dinitratedihydrate; [LCo(μ-O2)CoL](NO3)2.2H2O (L = suc(en)2), hereafter the complex, was investigated at 420 nm wavelength of maximum absorption of the complex under the conditions hydrogen ions concentration = 1.8 × 10−2 mol dm−3, temperature = 24 ± 1 °C, [LCo(μ-O2)CoL2+] = 1.4 × 10−4 mol dm−3 and ionic strength = 0.5 mol dm−3. First order in [LCo(μ-O2)CoL2+] and [Lys] were obtained but inverse first order in [H+]. The proposed overall rate equation is as shown:

Rate
=
(

k
1

k
2

+

K
1

k
3

k
4

1

[

H
+

]

)
[
LCo
(
μ

O
2

)

CoL

2
+

]
[
Lys
]

$$Rate = ({{k_1 } \over {k_2 }} + {{K_1 k_3 } \over {k_4 }}{1 \over {[H^ + ]}})[LCo(\mu O_2 )CoL^{2 + } ][Lys]$$

Rate of the reaction decreases when hydrogen ions concentration increase and exhibited converse effect with increase in concentration of ionic strength from 0.1 – 1.3 mol dm−3. Added cations and anions affected the reaction rate and the Michaelis-Menten plot passed through the origin indicating no absence of intermediate complex in the electron transfer processes. Putting all the results obtained together, the most probable reaction mechanism is in favour of outer-sphere and an appropriate rate law is established using steady state approximation.
Allelopathic Effect of Dodder on Different Varieties of Lucerne and Bird’s Foot-Trefoil
Authors: Valcheva Ekaterina , Popov Vladislav , Zorovski Plamen , Golubinova Irena , Marinov-Serafimov Plamen , Velcheva Iliana , Petrova Slaveya 
Published: April 2018

Summary
The aim of this study was to evaluate the allelopathic effect of cold aqueous extracts, both fresh and dry biomass of dodder (Cuscuta epithymum L.) on lucerne (Medicago sativa L.) and bird’s foot-trefoil (Lotus corniculatus L.). Four different varieties of lucerne “Pleven 6”, “Dara”, “Roly”, “Multifoliolate”) and bird’s foot-trefoil (“Gran San Gabriele”, “Leo”, “Local population 1”, “Local population 2”) were studied in order to find some varieties with allelopathic tolerance. Ex-situ experiment was carried out as follows: 100 seeds of each variety were put in Petri dishes between filter paper, both cold extracts of parasitic weed biomass were pipetted at a ratio of 1:20 as against the seed mass and then were placed in a thermostat-operated device at a temperature of 22 ± 2°С. Distilled water was used as a control. Percentage inhibition, Index of tolerance and Index of plant development were calculated for assessment of the allelopathic effect of dodder on the early seedling growth, biomass synthesis and initial development of experimental varieties. As a whole, dry weed biomass was found as more toxic for the tested plants than the fresh one. Medicago sativa var. multifoliolate and Lotus corniculatus var. Local population 1 and Local population 2 showed a significant tolerance to the allelopathic influence of Cuscuta epithymum in all studied concentrations of aqueous extract of fresh weed biomass (25, 50 and 100 g l−1) and medium tolerance to aqueous extract of dry weed biomass (concentrations of 25 and 50 g l−1).
The Impact of Organic Agriculture on Biodiversity Conservation and Milk Quality for Traditional Cheese Production
Authors: Popović-Vranješ Anka , Paskaš Snežana , Becskei Zsolt , Jevtić Marija , Krstović Saša 
Published: April 2018

Summary
Organic farming represents agricultural practice that could contribute to the preservation of biological diversity and breeding of cows with the most desired milk quality attributes. Milk composition could vary widely according to genetic diversity of the animals and different feeding systems. These are related to higher dry matter content, fat, protein and a more favorable ratio of the saturated/unsaturated fatty acids, which is important in traditional cheese production. Standard chemical analyzes were performed and this paper shows the differences in the chemical properties and the fatty acid profile of milk, depending on the different breeds and breeding methods of animals. Simmental milk (indoors) was most abundant in dry matter and fat (13.01 and 4.30%, respectively) while protein and casein level was the highest in the Busha milk (3.67 and 2.63%, respectively). Holstein Friesian milk (organic) possessed a more constant composition and, together with Busha appropriate hygienic quality of milk (low level of somatic cells and total bacteria count). Also, milk from Holstein Friesian cows (organic) was disposed with better nutritional quality and more desirable fatty acid profile (SFA (63.40%), MUFA (30.79%) and PUFA (5.72 %)). On the other hand, Holstein Friesian (conventional) milk contained SFA (67.45%), MUFA (29.27%) and PUFA (3.28%) while Simmental (indoors) higher values of SFA (71.21%) and less MUFA (25.39%) and PUFA (3.40%). There are various ways to preserve biodiversity and the application of organic production standards in the traditional cheese production contributes to obtaining safer, quality products which are more recognizable on the market.
Green Barley as an Ingredient in Pasta: Antioxidant Activity and Sensory Characteristics Evaluation
Authors: Ivanišová Eva , Košec Martin , Brindza Ján , Grygorieva Olga , Tokár Marián 
Published: April 2018

Summary
The aims of the present study was to determine antioxidant activity, sensory properties as well as total polyphenol, flavonoid and chlorophyll content of raw and cooked pasta enriched by 1%, 3% and 5% addition of green barley powder. Results of antioxidant activity showed that increase of green barley addition increase antioxidant activity of pasta. The values in raw pasta obtained by DPPH ranged from 1.17 (control) to 1.81 (5% addition) mg TEAC/g DM, after cooking values ranged from 0.82 (control) to 1.59 (5% addition) mg TEAC/g DM. Similar tendency was signed by molybdenum reducing antioxidant power method. In enriched pasta was also found higher content of total polyphenol (0.19 in control raw sample and 1.81 mg GAE/g DM in pasta with 5 % of green barley addition; values of cooked pasta ranged from 0.10 in control sample to 0.73 mg GAE/g DM in pasta with 5 % of green barley addition) as well as total flavonoid content (results of raw pasta were from 0.00 in control sample to 0.41 mg QE/g DM in pasta with 5% of green barley addition; values of cooked pasta were from 0.00 in control sample to 0.29 mg QE/g DM in variant with 5% green barley). Green barley also enriched pasta for chlorophyll with the best results in 5% addition. From prepared variants of enriched pasta the best overall acceptability was sign in 3% of green barley addition. Pastas enriched with plant-derived bioactive compounds such as green barley may confer health benefits to consumers.
Improvements of doubled haploid production protocol for white cabbage (Brassica oleracea var. capitata L.)
Authors: Pilih Katarina Rudolf , Potokar Urška Karolina , Bohanec Borut 
Published: April 2018

Abstract
Protocols leading to the development of doubled haploid (DH) lines by microspore culture are widely used in white cabbage (Brassica oleracea var. capitata L.), but efficiency varies according to the cultivar and induction procedure. Forty different genotypes consisting of F1 cultivars and their crosses with responsive doubled haploid lines were tested to evaluate the androgenic response. In total, 20,032 embryos were produced. On average, the haploid induction response of F1 cultivars was 7.0 embryos/Petri dish, but the average of these hybrids crossed to responsive DH lines was 26.6 embryos/Petri dish. In seven reciprocal crosses, a difference was observed in just one, meaning that the maternal effect probably has a minor influence on haploid embryogenesis in cabbage. Addition of 0.02% activated charcoal (AC) to the induction media increased embryo formation in several low-responsive genotypes, but its effect on embryo formation of high-responsive genotypes was predominantly negative, although larger embryos were formed on media containing AC than without AC. Further development into plantlets was tested by two procedures. Formed embryos were either transferred directly to regeneration medium or treated with abscisic acid and desiccated for 4 weeks. Regrowth and further development reached on average 15.5 and 57.6%, for the first and second procedures, respectively. Plantlets developed by direct transfer often exhibited abnormal development or hyperhydricity, unlike the desiccated embryos. Spontaneous diploidisation of embryos reached 42.5% in total and was not affected by AC added to the induction media.
Dilated Cardiomiopathy - Anatomic-Clinical Study
Authors: Ovidiu Tica , Anca Tica Otilia , Larisa Rosan , Madalina Vidican , Elena Rosca , Vlad Pantea , Ioana Ignat Romanul , Anca Sandor-Huniadi , Mircea Sandor , Cosmin Vesa , Katalin Babes , Mircea-Ioachim Popescu 
Published: April 2018

Abstract
Introduction. Dilated cardiomyopathy (DCM) is characterized by global cardiac dilation associated with left ventricular (LV) systolic dysfunction without valvar substrate or ischemic heart disease. Diagnosis of idiopathic DCM can only be sustained after excluding other nongenetic causes.
Methods. This study was performed on a cohort of 256 patients who died in Emergency County Hospital of Oradea and had diagnosis of DCM; the study was performed on a period of 2 years, from January 2014 until the end of December 2015. These patients were differentiated according to social criteria, background, department of admission, number of autopsies and co-morbidities.
Results and Discussion. Diagnosis of DCM was more common in male patients up to the age of 70; after this age the tendency is towards equalization. In patients aged 61-80 years, DCM played a major role in tanatogenesis. Existing clinical trials have shown that patients with idiopathic DCM have a lower mortality than patients with cardiac ischemic disease.
Conclusions. Despite the possibility of diagnosis with increased sensitivity and the large number of therapeutic options, multicentre studies and registries are needed to improve the life expectancy of these patients.
Mist-Netting of Migrating Bee-Eaters Positively Influences Honey Bee Colony Performance
Authors: Łangowska Aleksandra , Yosef Reuven , Skórka Piotr , Tryjanowski Piotr 
Published: April 2018

Abstract
Bee-eaters (Meropidae) are considered agricultural pests and their presence provokes conflicts with beekeepers and farmers who rely on the pollination services of honey bees. This problem is often deal with through the mass killing of the birds, even though the quantitative evidence on the impact of bee-eaters on honey bee colonies is scarce. The current paper reports the performance of honey bee colonies protected with mist nets from migrating flocks of European bee-eaters Merops apiaster in Israel. In the study the weight gains of bee hives surrounded by mist nets were 6.44 times higher than that of unprotected hives (26.4 kg vs. 4.1 kg). The results confirmed that bee-eaters locally pose a problem to apiaries and potentially to the crops that require pollination. Mist- netting appeared to be an effective mitigation method for alleviating conflicts between beekeepers and bee-eaters. However, the study also showed that bees were able to differentiate between their main predator and other avian species trapped in mist nets and stung only bee-eaters. Moreover, the bees were targeting the most vulnerable body parts of birds which resulted in some bird fatalities. Therefore, due to accidental mortal- ity of birds, mist-netting is recommended only on the migratory routes in cases when bee hives cannot be moved to other areas.
Spatial Rack Drives Pitch Configurations: Essence and Content
Authors: Abadjieva Emilia , Abadjiev Valentin , Naganawa Akihiro 
Published: April 2018

Abstract
The practical realization of all types of mechanical motions converters is preceded by solving the task of their kinematic synthesis. In this way, the determination of the optimal values of the constant geometrical parameters of the chosen structure of the created mechanical system is achieved. The searched result is a guarantee of the preliminary defined kinematic characteristics of the synthesized transmission and in the first place, to guarantee the law of motions transformation. The kinematic synthesis of mechanical transmissions is based on adequate mathematical modelling of the process of motions transformation and on the object, realizing this transformation. Basic primitives of the mathematical models for synthesis upon a pitch contact point are geometric and kinematic pitch configurations. Their dimensions and mutual position in space are the input parameters for the processes of design and elaboration of the synthesized mechanical device. The study presented here is a brief review of the theory of pitch configurations. It is an independent scientific branch of the spatial gearing theory (theory of hyperboloid gears). On this basis, the essence and content of the corresponding primitives, applicable to the synthesis of spatial rack drives, are defined.
Experimental Characterization of the Energy Absorption of Functionally Graded Foam Filled Tubes Under Axial Crushing Loads
Authors: Ebrahimi Saeed , Vahdatazad Nader , Liaghat Gholamhossein 
Published: April 2018

AbstractThis paper deals with the energy absorption characterization of functionally graded foam (FGF) filled tubes under axial crushing loads by experimental method. The FGF tubes are filled axially by gradient layers of polyurethane foams with different densities. The mechanical properties of the polyurethane foams are firstly obtained from axial compressive tests. Then, the quasi-static compressive tests are carried out for empty tubes, uniform foam filled tubes and FGF filled tubes. Before to present the experimental test results, a nonlinear FEM simulation of the FGF filled tube is carried out in ABAQUS software to gain more insight into the crush deformation patterns, as well as the energy absorption capability of the FGF filled tube. A good agreement between the experimental and simulation results is observed. Finally, the results of experimental test show that an FGF filled tube has excellent energy absorption capacity compared to the ordinary uniform foam-filled tube with the same weight.
Evolution of the dicalcium phosphate-dihydrate (DCPD) coating created by large amplitude sinusoidal voltammetry (LASV) on corrosion resistance of the ZW3 magnesium alloy in chloride containing environment
Authors: Kajánek D. , Hadzima B. , Pastorek F. , Jacková M. Neslušan 
Published: April 2018

Abstract
The contribution is focused on the preparation of coating based on the dicalcium phosphate-dihydrate (DCPD) on the surface of ZW3 magnesium alloy. For the preparation of the coating a cathodic electrodeposition technique called Large Amplitude Sinusoidal Voltammetry (LASV) was used. The DCPD layer was prepared at the temperature of 22 ± 2 °C in electrolyte composed of 0.1M Ca(NO3).4H2O, 0.06 M NH4H2PO4 and H2O2. Electrochemical characteristics were evaluated by electrochemical impedance spectroscopy (EIS) in 0.1M NaCl solution. The obtained data in form of Nyquist plots were analysed by the equivalent circuit method. It is clear from the measured values of polarization resistance Rp that dicalcium phosphate-dihydrate (DCPD) layer prepared by LASV electro-deposition technique improved corrosion resistance of ZW3 alloy in the chosen environment.
Visibility and perception analysis of city monuments: The case of Bratislava city centre (Slovakia)
Authors: Oťaheľ Ján , Ira Vladimír , Hlavatá Zuzana , Pazúr Róbert 
Published: April 2018

Abstract
City monuments attract tourists, especially at places with efficient viewpoints. The conditions of visibility of eight historical monuments in the city of Bratislava were evaluated using GIS on a 3D landscape, employing the criteria of distance, impressiveness, size and the number of visible monuments. The visual quality of 15 selected viewpoints was verified by surveying more than 300 respondents about their views of the monuments from similar locations. These approaches allow us to assess the conformity of visual quality analysis conducted in objective and subjective ways. The most attractive viewpoints ranked by observers were remote from the historic town and provided views of several monuments, as well as a comprehensive panoramic view of the centre of Bratislava. The approaches to assessing visual quality analysis presented in this study represent a comprehensive way of defining and verifying which places are the best for effective sightseeing of a city’s monuments.
Correction of Navigational Information Supplied to Biomimetic Autonomous Underwater Vehicle
Authors: Praczyk Tomasz 
Published: April 2018

Abstract
In order to autonomously transfer from one point of the environment to the other, Autonomous Underwater Vehicles (AUV) need a navigational system. While navigating underwater the vehicles usually use a dead reckoning method which calculates vehicle movement on the basis of the information about velocity (sometimes also acceleration) and course (heading) provided by on-board devicesl ike Doppler Velocity Logs and Fibre Optical Gyroscopes. Due to inaccuracies of the devices and the influence of environmental forces, the position generated by the dead reckoning navigational system (DRNS) is not free from errors, moreover the errors grow exponentially in time. The problem becomes even more serious when we deal with small AUVs which do not have any speedometer on board and whose course measurement device is inaccurate. To improve indications of the DRNS the vehicle can emerge onto the surface from time to time, record its GPS position, and measure position error which can be further used to estimate environmental influence and inaccuracies caused by mechanisms of the vehicle. This paper reports simulation tests which were performed to determine the most effective method for correction of DRNS designed for a real Biomimetic AUV.