bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Mixed Methods Study Exploring Barriers and Enablers to Physical Activity Participation Among Women in Coastal Communities.
Authors: Ominyi Jude , Clifton Andrew 
Published: November 2024

Abstract

Background: Physical inactivity is a critical global health issue that contributes to increased morbidity and mortality rates worldwide. Regular physical activity (PA) benefits both physical and mental health, with particular importance for women, who face increased risks for chronic conditions associated with inactivity. This study examines barriers to and enablers of PA participation among women in coastal communities in East England, a population particularly affected by socioeconomic, environmental, and logistical challenges to maintaining active lifestyles.
Methods: This study employed a mixed-methods convergent parallel design, integrating qualitative and quantitative data collected from 112 adult women recruited through local PA and weight loss programmes. Data collection utilised the International Physical Activity Questionnaire (IPAQ) and the Exercise Benefits and Barriers Scale (EBBS), alongside scenario-based and open-ended qualitative questions. The quantitative data were analysed via descriptive statistics and logistic regression in SPSS, whereas the thematic analysis of the qualitative data was conducted in NVivo.
Results: Quantitative findings indicate that healthcare professionals (40%) are the primary source of PA information, with health benefits (36%) being the main motivator. Key barriers include family responsibilities (45%), low self-confidence (31%), and limited access to facilities (27%). Logistic regression revealed that women with family caregiving roles and existing health conditions were less likely to engage in PA. Qualitative data further highlight psychological and environmental barriers, alongside motivators such as medical advice, social support, and personal goals, which significantly impact PA participation.
Conclusions: Women in coastal communities face unique socioenvironmental and psychological barriers to PA engagement. Effective interventions may need to incorporate multilevel, community-based approaches that address these specific challenges. This study highlights the potential for tailored interventions that leverage health advice, support networks, and culturally relevant programming to foster sustainable PA engagement among women in similar settings.
Ruptured tubal stump ectopic pregnancy after previous ipsilateral salpingectomy:a case report and literature review.
Authors: Kibret Asfaw 
Published: November 2024

Abstract

Ectopic pregnancy is life threatening condition occuring due to the implantation of fertilized ovum out side the uterine endometrial cavity. Its common site is fallopian tube. Stump ectopic pregnancy after previous salpingectomy on ipsilateral tube is the rare occurrence. We present a 26yrs old female patient with tubal stump ectopic pregnancy who was undergone salpingectomy on ipsilateral tube one year back. This is the first report from ethiopia.
Planejamento da aposentadoria e os efeitos em trabalhadores: protocolo de revisão sistemática
Authors: Candido Pedro Danielli Rafaeli , Haddad Maria do Carmo Fernandez Lourenço , Mendonça Fernanda Santiago Santos , Salci Maria Aparecida 
Published: November 2024

Introdução: o aumento da população idosa em todo o mundo acarreta a necessidade da construção e implantação de políticas e programas de saúde que atendam às necessidades dessa parcela da população. Método: trata-se de um protocolo de revisão sistemática, de acordo com o checklist Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Serão incluídos todos os artigos publicados em periódicos científicos que descrevam etapas de desenvolvimento, implantação, avaliação de resultados e/ou efeitos de estratégias de planejamento da aposentadoria. Serão excluídos os artigos completos, mas não disponível na íntegra, que possuem informações incompletas e estudos que não respondem à pergunta de pesquisa. Serão utilizadas cinco bases de dados para o estudo. Resultados: os resultados serão apresentados utilizando um diagrama de fluxo, conforme preconiza a JBI. Para facilitar a síntese dos registros incluídos na pesquisa utilizou-se o modelo de quadro. O protocolo foi registrado na International prospective register of systematic reviews (PROSPERO). Discussão: estudos de revisões sistemáticas são potenciais auxiliadores na identificação de ações que impactaram o processo de trabalho ou a saúde dos trabalhadores de forma positiva ou negativa, servindo como importante fonte para a adoção de estratégias que valorizem a saúde e qualidade de vida do trabalhador. Considerações finais: apesar dos diversos benefícios de preparar os trabalhadores para o momento da aposentadoria não encontrou revisões sistemáticas que objetivassem descrever as estratégias existentes para esse planejamento da aposentadoria e os efeitos gerados nos trabalhadores.
Palavras-Chave: Idoso; Aposentadoria; Saúde do Trabalhador; Qualidade de Vida.
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer
Authors: Wang Shouguang , Zhang Lijuan , Li Dongbing , Gou Miaomiao 
Published: November 2024

Background:
The role of HEPACAM family member 2 (HEPACAM2) is unclear in
colorectal cancer (CRC).

Objective:
The objective of this study was to perform an extensive examination of HEPACAM2
and validate it experimentally in CRC.

Methods:
This study investigated the significance of HEPACAM2 in CRC and its potential diagnostic
utility utilizing data from the Cancer Genome Atlas (TCGA) database. Additionally, the
study examined potential regulatory networks involving HEPACAM2, including its associations
with immune infiltration, immune checkpoint genes, tumor mutational burden (TMB), microsatellite
instability (MSI), mRNA expression-based stemness index (mRNAsi), and drug sensitivity in
CRC. The expression of HEPACAM2 was further validated using the GSE89076 dataset, and
quantitative reverse transcription PCR (qRT-PCR) was employed to confirm HEPACAM2 expression
levels in six pairs of CRC tissue samples.

Results:
HEPACAM2 exhibited abnormal expression patterns in various types of cancer, including
CRC. A decrease in HEPACAM2 expression levels in CRC was found to be significantly correlated
with the T stage (p < 0.001). Reduced HEPACAM2 expression in CRC patients was also
linked to poorer overall survival (OS) (p = 0.007). The expression levels of HEPACAM2 in CRC
patients were identified as an independent prognostic factor (p = 0.016). Furthermore, HEPACAM2
was associated with TCF-dependent signaling in response to WNT, G2/M checkpoints,
and other pathways. The expression of HEPACAM2 in CRC was found to be associated with immune
infiltration, immune checkpoint genes, TMB / MSI, and mRNAsi. Additionally, the expression
of HEPACAM2 in CRC was significantly and inversely correlated with the drug sensitivities
to gw772405x and 6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione. qRT-PCR confirmed that
the expression level of HEPACAM2 was found to be lowly expressed in CRC tissues.

Conclusion:
These findings suggest that HEPACAM2 may serve as a potential prognostic biomarker
and immunotherapeutic target for CRC patients.
Synthesis, Biological Evaluation, Molecular Docking Studies and ADMET Prediction of Oxindole-Based Hybrids for the Treatment of Tuberculosis
Authors: Patel Vaishali Pavalbhai , Tripathi Rati Kailash Prasad , Mandal Snigdha Das 
Published: November 2024

Introduction:
With a projected mortality toll of 1.4 million in 2019, tuberculosis
(TB) continues to be a significant public health concern around the world. Studies of novel
treatments are required due to decreased bioavailability, increased toxicity, increased side effects,
and resistance of several first- and second-line TB therapies, including isoniazid and ethionamide.

Methods:
This study reports the synthesis of oxindole-based hybrids as potent InhA inhibitors
targeting Mycobacterium tuberculosis. The synthesized compounds (5a-5e and 8a-8c) were
evaluated for their anti-mycobacterial activity against Mycobacterium tuberculosis and nontuberculous
mycobacteria (NTMs), viz. M. abscessus (ATCC 19977), M. fortuitum (ATCC 6841),
and M. chelonae (ATCC 35752) using the Microplate Alamar Blue Assay (MABA). Molecular
docking studies were performed using AutoDock Vina to explore the binding interactions of
these compounds with the InhA enzyme (PDB: 2NSD). Additionally, biochemical and histopathological
studies were conducted to assess the hepatotoxicity of the lead compounds. Insilico
molecular properties and ADMET properties of the synthesized compounds were predicted
using SwissADME and Deep-PK online tools to assess their drug-likeness.

Results:
Among the tested compounds, 8b exhibited significant anti-mycobacterial activity with
a minimum inhibitory concentration (MIC = 1 μg/mL) comparable to the reference drug ethambutol.
Further, the compound demonstrated a binding affinity and orientation similar to the reference
inhibitor 4PI, indicating its potential as a potent InhA inhibitor, and was found to be stabilized
within the binding pocket of InhA through H-bonding, hydrophobic and van der Waal’s
interactions. Besides, the compounds hepatotoxicity assessment studies depicted that 8b showed
no significant liver dysfunction or damage to liver tissues. Additionally, 8b adhered to
Lipinski’s rule of five and Veber’s rule, displaying favourable pharmacokinetic and drug-like
properties, including high human intestinal absorption, distribution, and acceptable metabolic
stability and excretion.

Conclusion:
Compound 8b emerged as a promising candidate for further optimization and development
as a therapeutic agent for tuberculosis, offering a new avenue for tackling tuberculosis.
Robust Somatic Copy Number Estimation using Coarse-to-fine Segmentation
Authors: Culibrk Luka , Grewal Jasleen K. , Pleasance Erin D. , Williamson Laura M. , Mungall Karen , Laskin Janessa , Marra Marco A. , Jones Steven J.M. 
Published: November 2024

Introduction:
Cancers routinely exhibit chromosomal instability that results in copy
number variants (CNVs), namely changes in the abundance of genomic material. Unfortunately, the
detection of these variants in cancer genomes is difficult.

Methods:
We present Ploidetect, a software package that effectively identifies CNVs within wholegenome
sequenced tumors. Ploidetect utilizes a coarse-to-fine segmentation approach which yields
highly contiguous segments while allowing for focal CNVs to be detected with high sensitivity.

Results:
We benchmark Ploidetect against popular CNV tools using synthetic data, cell line data,
and real-world metastatic tumor data and demonstrate strong performance in all tests. We show that
high quality CNVs from Ploidetect enable the identification of recurrent homozygous deletions and
genes associated with chromosomal instability in a multi-cancer cohort of 687 patients. Using highly
contiguous CNV calls afforded by Ploidetect, we also demonstrate the use of segment N50 as a
novel metric for the measurement of chromosomal instability within tumor biopsies.

Conclusion:
We propose that the increasingly accurate determination of CNVs is critical for their
productive study in cancer, and our work demonstrates advances made possible by progress in this
regard.
GVNNVAE: A Novel Microbe-Drug Association Prediction Model based on an Improved Graph Neural Network and the Variational Auto-Encoder
Authors: Chen Yiming , Zhang Zhen , Liu Xin , Zeng Bin , Wang Lei 
Published: November 2024

Abstract:
Microorganisms play a crucial role in human health and disease. Identifying potential microbe-
drug associations is essential for drug discovery and clinical treatment. In this manuscript, we
proposed a novel prediction model named GVNNVAE by combining an Improved Graph Neural
Network (GNN) and the Variational Auto-Encoder (VAE) to infer potential microbe-drug associations.
In GVNNVAE, we first established a heterogeneous microbe-drug network N by integrating
multiple similarity metrics of microbes, drugs, and diseases. Subsequently, we introduced an improved
GNN and the VAE to extract topological and attribute representations for nodes in N respectively.
Finally, through incorporating various original attributes of microbes and drugs with above
two kinds of newly obtained topological and attribute representations, predicted scores of potential
microbe-drug associations would be calculated. Furthermore, To evaluate the prediction performance
of GVNNVAE, intensive experiments were done and comparative results showed that
GVNNVAE could achieve a satisfactory AUC value of 0.9688, which outperformed existing competitive
state-of-the-art methods. And moreover, case studies of known microbes and drugs confirmed
the effectiveness of GVNNVAE as well, which highlighted its potential for predicting latent
microbe-drug associations.
QSAR Modeling and Molecular Docking Studies of New Substituted Pyrazolyl-Pyrimidinones as Potent HIV-1 Inhibitors
Authors: Hamdache Badr , Tabti Kamal , Er-rajy Mohammed , Dib Mustapha , ElFarouki Khadija , Ouchetto Khadija , Elhalaoui Menana , Hafid Abderrafia , Khouili Mostafa , Ouchetto Hajiba 
Published: November 2024

Background:
Pyrazolyl-pyrimidinone derivatives are important heterocyclic compounds.
A novel HIV-1 (human immunodeficiency virus type 1) inhibitors based on these components were
designed as potential drug candidates for AIDS (acquired immunodeficiency syndrome) therapy.

Objective:
This research aims to develop a predictive mathematical model linking the biological activity
and physicochemical properties of pyrazolyl-pyrimidinones derivatives and to identify the interactions
between the most active compound and the HIV-1 active site.

Method:
A QSAR-2D study was conducted on 40 pyrazolyl-pyrimidinone derivatives, followed by
molecular docking of the most active compounds.

Results:
Principal Component Analysis (PCA) was used to select the best descriptors for building
QSAR models using Multiple Linear Regression (MLR), Multiple Nonlinear Regression (MNLR),
and Artificial Neural Networks (ANN). The MLR model achieved R² = 0.70, Q²Cv = 0.54, and successful
Y-randomization (R = 0.83). The MNLR model had an R² of 0.81 and low mean square error
RMSE = 0.17, while the ANN model showed ρ = 1.5 and RMSE = 0.15. Docking studies confirmed
key interactions between compounds 1 and 11 with the HIV-1 active site. The results of molecular
packaging Substances 11 and 1 have the lowest energy levels of -13.26 kcal/mol and -12.5
kcal/mol, respectively, and have more than one hydrogen bond. The molecular docking validation
finds RMSD = 0.821.

Conclusion:
This study allowed the establishment of robust QSAR models with a good predictive
capacity, confirmed by several statistical indicators, with the aim of inhibiting HIV-1. The models
showed satisfactory reliability and docking studies identified key interactions between the compounds
and the active sites of HIV-1, thus reinforcing their profile as promising candidates for the
development of new antiviral treatments.
Bipolar Expected Value-based MCDM Technique for Wastewater Management under Trapezoidal Bipolar Fuzzy Environment
Authors: Garai Totan 
Published: November 2024

:
Kolkata is located on western bank of the Hooghly River. Wastewater from the city is discharged into this river and pollutes the river water. It causes maximum negative effects than positive impacts. Many uncertainties and bipolarity occur for this reason. Through the bipolar fuzzy concept, we can easily take the determination for this situation. A bipolar fuzzy expected is an effective tool for illustrating uncertainty and fuzziness in a decision-making problem. There-fore, in this paper, we have invented the bipolar expected value of bipolar fuzzy numbers. In addition, we have invented a few formulae and a theorem based on bipolar expected values. Using this bipolar expected value, we developed a novel MCDM technique, and it's employed for wastewater management problems in Kolkata city under a bipolar environment. Numerically, we have solved the wastewater management problem under a bipolar fuzzy environment.
Environment-friendly Synthesis of AgNPs from Fimbristylis miliacea Flower Extract: Characterization and its Applications as an Antioxidant Activity, Anticancerous Activity and in the Reduction of 4-Nitrophenol
Authors: Patil Pandurang Y. , Manjare Satish B. , Jadhav Rujuda R. 
Published: November 2024

Background:
Silver metal is useful in a variety of fields. Different silver salts exhibit
good application in the organic transformation. The use of a green methodology in AgNPs preparation
has gained interest of young researchers. Plant systems are employed in the green approach
of preparing AgNPs, serving as both a stabilizing and reducing agent. Silver nanoparticles
(AgNPs) made from silver salts exhibit a variety of biological activities and may be useful in organic
transformation.

Method:
AgNPs were synthesized with the use of flower extract from Fimbristylis miliacea,
which acts as a stabilizing and reducing agent.

Result:
Fimbristylis miliacea flower extract is used as a reducing and stabilising agent for preparation
of AgNPs. These synthesised AgNPs were characterised by using FTIR, XRD, FESEM/
EDS, HR-TEM, TGA, and ICP-AES. Fimbristylis milliciea flower extract was subjected to
FTIR and HR-LCMS analysis in order to identify the phytoconstituents that are responsible for the
reduction of AgNO3. The HR-TEM shows particle size between 8.98434+0.69669nm and
19.07464+1.4384nm. The size of AgNPs determined by using HR-TEM shows good agreement
with XRD particle size. The synthesized AgNPs show excellent antioxidant properties with
IC50=56.45 μg/mL. The present study confers significant cytotoxic activity against MDA-MB-231
human breast cancer cell line culture (IC50= 61.97 μg/ml). The AgNPs show a faster reduction of
4-nitrophenol.

Conclusion:
In conclusion, we have prepared AgNPs by using Fimbristylis miliacea flower extract.
The study further concludes that green synthesis of AgNPs has many advantages as compared
to chemical methods, such as cost-effectiveness, rapid, and environment-friendly methods.
The results indicated that the biosynthesized AgNPs have significant cytotoxic activity against the
MDA-MB-231 breast cancer cell line. Further, it indicates that biosynthesized AgNPs can be a
potential alternative agent for human breast cancer therapy. The cytotoxic potential can be used
for treatments and provides a new method to develop molecules for cancer therapy. The catalytic
activity of AgNPs was examined by using the reduction of 4-nitrophenol. It shows that the reduction
of 4-nitrophenol in 6 minutes is confirmed by using 1H NMR analysis.
Effectiveness of Self-Management Programs Among Athletes With Patellofemoral Pain Syndrome: Protocol for a Systematic Review
Authors: Masoudi Ameen , Chemane Nomzamo , Useh Ushotanefe , Bello Bashir , Magida Nontembiso 
Published: November 2024

Background
Patellofemoral pain syndrome is a highly prevalent overuse knee injury in athletic populations associated with pain and functional limitations, exacerbated by activities such as running, pivoting, cycling, and jumping. Self-management programs empowering athletes to take an active role in controlling their symptoms for chronic musculoskeletal conditions such as patellofemoral pain syndrome have grown in popularity. However, the efficacy of self-management programs specifically for athletes with patellofemoral pain syndrome is unclear due to limited and heterogeneous evidence.

Objective
The systematic review study will evaluate the effectiveness of self-management programs on pain and function, in athletes with patellofemoral pain syndrome.

Methods
PubMed/MEDLINE, Cochrane Library, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsycINFO databases will be systematically searched using terms related to “patellofemoral pain syndrome,” “self-management,” and “athletes.” Interventional studies that are randomized and nonrandomized controlled trials will be included, comparing self-management programs to other treatments or control conditions among athletes with patellofemoral pain syndrome. Four reviewers will independently screen studies, extract data using the COVIDENCE software, and assess the quality of the study and evidence using the Pedro scale of risk of bias tool and GRADE approach, respectively. If feasible, a meta-analysis will be performed using the RevMan (version 5.4; the Cochrane Collaboration).

Results
The systematic review is currently in the search phase, with the authors refining search strings for the selected databases. The final search strings are expected to be ready by March 2024, and the review is projected to be completed by July 2024.

Conclusions
This systematic review protocol outlines a rigorous methodology for evaluating the effectiveness of self-management programs among athletes with patellofemoral pain syndrome. The findings will inform clinical practice and guide the development of tailored interventions to optimize outcomes for athletes with patellofemoral pain syndrome.

Trial Registration
PROSPERO CRD42023492746; https://tinyurl.com/c5jze9ca

International Registered Report Identifier (IRRID)
PRR1-10.2196/58340
Evaluating pile foundation design due to groundwater level lowering
Authors: Nguyen Vo Ai Mi , Le Hoang , Le Thi Anh Hong , Nguyen Huu Truong 
Published: November 2024

In Viet Nam, ground subsidence has been occurring at an alarming rate, raising concerns for pile foundation design. This issue is primarily caused by excessive groundwater extraction for water supply, irrigation, aquaculture, and other uses. Thus, in this study, the evaluation of pile capacity due to groundwater level (GWL) lowering as a preliminary guideline for structures is proposed. This study analyzed different cases of GWL lowering from 0 m to 2 m, and pile size varied from 18 x 18 cm to 45 x 45 cm, to evaluate the allowable bearing capacities for single piles and pile groups. The results indicated that when lowering the GWL from 0 to 2 m, the allowed bearing capacity varied by 5.75–174.70 tons for single piles and 11.95–808.18 tons for pile groups. Besides, when the pile size increased, the bearing capacity increased in the range of 6.38–41.46 tons (size 18 x 18 cm) to 16.30–174.70 tons (size 45 x 45 cm) for a single pile and 11.95–191.81 tons (size 18 x 18 cm) to 33.49–808.18 tons (size 45 x 45 cm). The result of this study underscores the significance of predicting the bearing capacity of pile foundations due to the variation in groundwater level.