bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19
Authors: Calcaterra Valeria , De Santis Raffaella , Braghieri Davide , Zanelli Sara , Zuccotti Gianvincenzo 
Published: October 2024

IntroductionConcurrent alterations in the metabolic profile and thyroid dysfunction, including non-thyroidal illness syndrome (NTIS) has been reported in multisystem inflammatory syndrome in children (MIS-C). Considering the influence of thyroid hormones (TH) on lipid metabolism, we explored the relationship between thyroid function and the atherogenic lipid profile in children with MIS-C at admission and during a 12-month follow-up.Patients and methodswe considered children admitted for MIS-C. Total and HDL cholesterol, triglycerides (TG), fasting plasma glucose, fasting plasma insulin as well as free T3 (FT3), free T4 (FT4), and TSH were assessed at diagnosis within 24 h of admission and during follow-up. TG/HDL ratio, no-HDL/HDL ratio and atherogenic index of plasma was also considered as atherogenic risk markers.Resultswe monitored 56 children. On admission, pathological levels of FT3, FT4, TSH, TG, TC, HDL, TG/HDL ratio, no-HDL/HDL ratio, and AIP were detected. Correlation analyses revealed associations between FT3, FT4, and lipid markers and TSH with TG. During monitoring, while complete restoration of TH balance was achieved at 12 months, some patients still exhibited an altered lipid profile, without correlation between thyroid function and lipid markers.Conclusionswe supported a relationship between thyroid function and an atherogenic lipid profile in children with MIS-C. This may result from interactions between adaptive and innate metabolic responses and genetic predisposition. Elucidating the relationship between TH and metabolic pathways during infections could help identify new biomarkers to prevent acute and fatal outcomes, improving patient prognosis and protecting long-term health.
Low plasma levels of BTLA and LAG-3 before HCV therapy are associated with metabolic disorders after HCV eradication in persons with HIV/HCV coinfection: a retrospective study
Authors: Martín-Escolano Rubén , Virseda-Berdices Ana , Berenguer Juan , González-García Juan , Brochado-Kith Oscar , Fernández-Rodríguez Amanda , Díez Cristina , Hontañon Victor ,   The Marathon Study Group, Resino Salvador , Jiménez-Sousa María Ángeles 
Published: October 2024

BackgroundUnderstanding the predictors of metabolic disorders in persons with HIV/HCV coinfection post-HCV therapy is crucial for improving patient outcomes. Since immune checkpoint proteins are usually upregulated in these persons with HIV/HCV coinfection, we aimed to evaluate the association between plasma immune checkpoint proteins at baseline (before HCV therapy) and metabolic disturbances during the follow-up (about 5 years after successful HCV treatment) in persons with HIV/HCV coinfection.MethodsWe performed a retrospective study on 80 persons with HIV/HCV coinfection with advanced fibrosis or cirrhosis who cleared HCV infection after successful HCV therapy and were followed for about 5 years after completion of HCV treatment. Plasma samples were collected at baseline. Immune checkpoint proteins were analyzed using a Luminex 200™ analyzer. Outcomes were the development of a metabolic event (type 2 diabetes mellitus and/or dyslipidemia) and the change in Triglycerides and glucose (TyG) index.ResultsDuring follow-up, 21 (26%) patients developed metabolic events (type 2 diabetes mellitus/dyslipidemia), and 29 (46.0%) patients had an increase in TyG during the follow-up. Low baseline values of BTLA and LAG-3, two immune checkpoint proteins, were associated with the development of metabolic events (aAMR = 0.69 and aAMR = 0.71, respectively) and with increases in TyG values (aAMR = 0.72 and aAMR = 0.70, respectively). In addition, other immune checkpoint proteins were also inversely associated with increases in TyG.ConclusionWe discovered that low plasma levels of BTLA and LAG-3 before HCV therapy significantly correlate with an increased risk of developing metabolic disorders after treatment.
Clinical implication of electrocardiogram change in patients experiencing lung transplantation with end stage lung disease
Authors: Leem Ah Young , Yu Hee Tae , Sung MinDong , Chung Kyung Soo , Kim Yeonkyeong , Woo Ala , Kim Song Yee , Park Moo Suk , Kim Young Sam , Yang Young Ho , Kim Ha Eun , Lee Jin Gu , Kim Kyuseok , Kim Kyu Bom , Joung Boyoung , Park Junbeom , Lee Su Hwan 
Published: October 2024

IntroductionEnd-stage lung disease causes cardiac remodeling and induces electrocardiogram (ECG) changes. On the other way, whether lung transplantation (LTx) in end-stage lung disease patients are associated with ECG change is unknown. The object of this study was to investigate ECG changes before and after LTx in end-stage lung disease patients and whether these changes had clinical significance.MethodThis was a single-center retrospective cohort study of 280 end-stage lung disease patients who consecutively underwent LTx at a tertiary referral hospital. ECG findings before LTx and within 1 week and 1, 3, and 6 months after LTx were obtained and analyzed. To find clinical meaning, the ECG at 1 month after LTx was analyzed according to 1-year survival (survivor vs non-survivor groups). Survival data were estimated using the Kaplan–Meier method.ResultsSignificant differences were observed in the PR interval, QRS duration, QT interval, QTc interval, and heart rate before LTx and 1 month after LTx; the PR interval, QRS duration, QTc interval, and heart rate were decreased. Particularly, the QTc interval was significantly decreased 1 month after LTx, whereas there was no significant change in the QTc interval from 1 to 6 months thereafter. The PR interval, QT interval, QTc interval, and heart rate were significantly different between the survivor and non-survivor groups. The serial changes in QTc interval before LTx and 1 and 3 months after LTx were also significantly different between the survivor and non-survivor groups (p = 0.040 after adjusting for age and body mass index). Upon dividing the patients based on the range of QTc interval change ≤ -8 ms, &gt;-8–10 ms, &gt;10–35 ms, &gt;35 ms), the survival rate was significantly lower in the group whose QTc interval at 1 month after LTx decreased by &gt; 35 m (p = 0.019).ConclusionLTx in patients with end-stage lung disease may induce ECG changes. Patients whose QTc interval at 1 month after LTx decreased by &gt; 35 ms have a significantly higher 1-year mortality rate. Hence, these ECG changes may have clinical and prognostic significance.
Dual group-based trajectories of physical activity and cognitive function in aged over 55: a nationally representative cohort study
Authors: Wang Xiaotong , Hu Pei , Ai Yating , Zhou Shi , Li Yucan , Zhou Pengjun , Chen Gao , Wang Yuncui , Hu Hui 
Published: October 2024

BackgroundAs individuals age, they commonly experience reduced physical activity and cognitive decline. While evidence, there is limited trajectory research on their concurrent progression and interrelation in individuals over 55 years old.MethodsThe data was collected from 5,765 individuals aged over 55 years who participated in the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2020. Physical activity was measured by IPAQ, cognitive function by episodic memory, and mental intactness score. Separate sets of group-based trajectory models were fitted to identify physical activity trajectories and cognitive function trajectories. Multivariate logistic regression was used to estimate the association between baseline characteristics and each set of trajectories. Group-based dual trajectory modeling (GBDTM) was applied to quantify these associations.ResultsGBDTM identified three distinct trajectory groups for physical activity and cognitive outcomes. The physical activity trajectories were classified as “Persistently low physical activity” (74.2%), “Decreasing physical activity” (13.7%), and “Rising physical activity” (12.1%). Similarly, cognitive function trajectories were categorized as “Persistently low cognitive function” (22.2%), “Persistently moderate cognitive function” (37.9%), and “Persistently high cognitive function” (39.9%). Notably, 15.6% of participants followed the trajectories of “Persistently low physical activity” and “Persistently low cognitive function.” The presence of a severe decline in physical activity was associated with an increased likelihood of poor cognitive function and vice versa. Age, sex, education, residential status, BMI, and visual impairment were identified as significant predictors for physical activity and cognitive decline.ConclusionThis study found that the GBDTM can determine the consistent trajectories of physical activity and cognitive function trajectories that persistently decline in individuals over 55 years. Analyses of predictive factors can be instrumental in promoting physical activity and delaying cognitive decline.
Gendered socio-economic and mental health effects of the COVID-19 pandemic among adults living in selected informal settlements in Kenya: an intersectional analysis
Authors: Mwanga Daniel M. , Odero Henry Owoko , Kadengye Damazo T. , Odunga Sally Atieno , Muluve Eva , Mugotitsa Bylhah , Wafubwa Ruth Nanjekho , Austrian Karen , Kiwuwa-Muyingo Sylvia 
Published: October 2024

BackgroundCOVID-19 pandemic had devastating socio-economic and health effects, including mental health. This study examines the intersectionality between gender and mental health outcomes among Kenyan adults in informal settlements of Nairobi, Kisumu, and Kilifi Counties during the COVID-19 crisis. This is necessary to inform mental health response in case of another pandemic.MethodsWe analyzed data collected in a longitudinal survey between July 2020 (fourth round) and February 2021 (fifth round). The data covered COVID-19-related effects on job loss, food insecurity, access to health services, and mental health. Participants were randomly sampled from existing cohorts at the Population Council. The outcomes of interest were depressive and anxiety disorders, combined into a binary composite outcome variable. Descriptive statistics included means for continuous variables and frequencies and proportions for categorical variables. Chi-square tests were used to examine the differences between groups. The relationship between the gendered COVID-19 socio-economic effects and participants’ mental health was examined using modified Poisson regression.ResultsA total of 4,050 participants were interviewed, 66% female and median age 38 [interquartile range (IQR): 29–46]. Complete income loss was strongly associated with negative mental health outcomes in multiple intersections with varied magnitudes. The association was larger among older females (≥50 years) (PR = 1.33, 95% CI = 1.17–1.51, p &lt; 0.001) than older males (PR = 1.22, 95% CI = 1.17–1.27, p &lt; 0.001). Partial loss of income was protective against negative mental health outcomes among young males (18–29 years) (PR = 0.81, 95% CI = 0.76–0.87, p &lt; 0.001) but linked to negative outcomes among middle-aged males (30–49 years old) (PR = 1.14, 95% CI = 1.12–1.16, p &lt; 0.001). Skipping meals was associated with negative mental health outcomes for both genders particularly the married (married male: PR = 1.49, 95% CI = 1.22–1.83, p &lt; 0.001; married female: PR = 1.42, 95% CI = 1.26–1.60, p &lt; 0.001).ConclusionWe observed significant gender differences in the prevalence of depressive symptoms and anxiety disorders during the COVID-19 pandemic, underscoring the importance of socio-economic factors and health services access in shaping mental health outcomes. Interventions targeting pandemic-related mental health issues should be gender-sensitive and address economic vulnerabilities such as job losses and food insecurity. Policies to mitigate these effects, especially for at-risk groups are crucial for reducing mental health burden in future crises.
SPATIAL ANALYSIS MOVEMENT OF DENGUE FEVER IN X HEALTH SERVICE, WEST JAVA INDONESIA: 2016 – 2019
Authors: Karmini Mimin , Hasan Nia Yuniarti , Ruliansyah Andri , Wahyudin Dindin 
Published: October 2024

Peningkatan kasus DBD sangat signifikan di Kabupaten Bandung Barat pada awal tahun 2019, hingga akhir Januari tahun 2019 mencapai 356 kasus. Belum ada informasi mengenai pola sebaran kasus dan lokasi yang berpotensi sebagi tempat penularan DBD. Informasi spasial dapat memperkirakan pola persebaran kasus dan dapat menjadi dasar pengambilan keputusan dalam pengendalian DBD. Tujuan penelitian ini adalah memetakan kasus DBD berdasarkan lokasi pasien di wilayah kerja Puskesmas X Kabupaten Bandung Barat, mengidentifikasi karakteristik pasien, menganalisis kepadatan penduduk, dan menentukan peta sebaran kasus DBD. Jenis penelitian merupakan deskriptif dengan pendekatan analisis laporan kasus dan spasial. Hasil analisis menunjukkan bahwa persebaran DBD di Puskesmas Cimareme tahun 2016 – 2019 menyebar ke arah timur laut dan barat daya. Daerah tersebut merupakan wilayah Desa Cilame dan Desa Tanimulya, yang merupakan wilayah dengan kecenderungan kasus dan kepadatan penduduk yang tinggi. Sedangkan Pola pergerakan kasus DBD pada tahun 2016, 2018 dan 2019 termasuk mengelompok, sedangkan tahun 2017 termasuk kategori mengacak. Upaya pengendalian kasus DBD dapat dilakukan melalui Gerakan 1 Rumah 1 Jumantik (G1R1J), membudidayakan kerjabakti setiap jumat (Jumat Bersih), dan pengendalian nyamuk dengan 3 M.
UJI COBA RANCANGAN MEDIA INTERAKTIF TERHADAP PENINGKATAN PENGETAHUAN TENTANG KARIES PADA ANAK SEKOLAH DASAR
Authors: Laut Deru Marah , Alisa Fitri Nur , Laela Dewi Sodja , Putri Megananda Hiranya 
Published: October 2024

Dental caries are dental and oral diseases that often occur in communities. Knowledge deficit is an indicator of a high incidence of dental caries. Media is a tool for delivering messages from sender to recipient, which can be used in the process of providing information to increase knowledge. Interactive media is a form of media that contains interactivity or a mutually active relationship between humans (users) and products (media). This study aimed to determine the results of a feasibility test of interactive media design for caries and trials of interactive media design for caries on student knowledge. This was a quantitative study with a pre-experimental design using a one-group pretest-posttest design. Before the trials of interactive media design to students' knowledge, preceded by an assessment of the feasibility test of the interactive media design by media experts. Samples were taken by total sampling with a total sample of 54 fifth grade students at SDIT Daarul Jihad. The results showed that the feasibility test for interactive media design get a feasibility percentage of 93.8% with a very feasible category. The result also showed there was an increase in knowledge of dental caries with an average pre-test score of 66.48 to 90.37 in the post-test average score the average increasing score 26,39. The Wilcoxon test showed a significance level of 0.000 < 0.05. This showed that there was an influence from the results of the trials interactive media design for caries on the increasing knowledge of fifth grade elementary school students.
EFEKTIVITAS PEMBERIAN COOKIES TAPE KETAN HITAM DAN EDUKASI GIZI TERHADAP PENURUNAN BERAT BADAN PADA REMAJA GEMUK
Authors: Rahmat Mamat , Gumilar Mulus , Dewi Maryati 
Published: October 2024

Black glutinous tape contains anthocyanins and has antioxidant activity as well as fiber. Consumption of black glutinous tape at least >11.5grams a day can prevent the occurrence of metabolic syndrome. One of the components of metabolic syndrome is the accumulation of fat around the waist (central obesity). The study aimed to determine the effectiveness of giving black glutinous rice tape cookies and nutritional education on weight loss in obese adolescents. The research design used quasi-experiments before and post-test two groups, by comparing the change in body weight between subjects who were given black tape cookies and subjects who were given nutrition education. The research was conducted in August-September 2017 at SMAN 2 and 3 Cimahi. The population is all students who are obese based on the BMI/U indicator of a Z score value of>+1. The minimum sample size in each group was 21. The study showed that there was an average weight decrease in the group given black glutinous rice tape cookies (0.53+1.41kg) and in the group given nutrition education (0.43+1.40kg). Based on statistical tests, there was no difference in weight before and after the intervention (p>0.05). Giving black glutinous rice tape cookies and providing nutrition education for one month to obese teenagers can lead to weight loss, but this has not been statistically proven. Further research is needed on the provision of sticky rice tape cookies with various weights and with a longer period of time so that the impact of weight loss on obese teenagers can be observed.
EDUCATION ON HEALTHY SNACKS USING NUTRITION BINGO GAMES TO IMPROVE KNOWLEDGE AND ATTITUDES ON BALANCED NUTRITION
Authors: Alvianti Neily Widya , Dewi Yulia Lanti Retno , Qadrijati Isna 
Published: October 2024

Permasalahan gizi dialami oleh masyarakat di seluruh dunia, termasuk Indonesia. Gizi buruk di Samarinda banyak dialami oleh anak usia sekolah dasar. Edukasi jajanan sehat pada anak usia sekolah dasar dapat dilakukan melalui permainan bingo nutrisi. Penelitian ini bertujuan untuk menganalisis pengaruh edukasi jajanan sehat melalui permainan bingo gizi terhadap peningkatan pengetahuan dan sikap gizi seimbang siswa sekolah dasar. Penelitian ini menggunakan metode kuasi eksperimen dengan desain kelompok kontrol pretest-posttest. Subjek penelitian adalah siswa SDIT Fastabikhul Khairat Samarinda yang berjumlah 80 orang yang dipilih menggunakan purposive sampling. Sebanyak 40 siswa sebagai kelompok eksperimen dan 40 siswa kelompok kontrol. Metode pengumpulan data menggunakan instrumen tes dan angket. Metode analisis data menggunakan uji dependen sample t-tes. Hasil penelitian menunjukkan edukasi jajanan sehat menggunakan N-BINGO dapat meningkatkan pengetahuan jajanan sehat siswa sebelum edukasi (rerata =19.07; SD = 2.81) menjadi sesudah edukasi (rerata = 29.74; SD = 3.72), t=11.072; p <.001, dan meningkatkan sikap gizi seimbang sebelum edukasi (rerata =55.87; SD = 3.43) menjadi (rerata = 70.78; SD = 4.37; p <.001); t = 16.114; ρ=.003.
MEDIA VIDEO ANIMASI MINDFUL EATING DAPAT DIGUNAKAN UNTUK MEMBANTU MENGATASI DISORDERED EATING PADA MAHASISWA
Authors: Ramadhani Aisyah Intan , Andayani Tri Rejeki , Hikmayani Nur Hafidha 
Published: October 2024

Disordered Eating (DE) or eating behavior problems are one of the issues that are increasingly significant among college students. Academic pressures and cultural changes influence the concept of the ideal body, leading to unhealthy eating behaviors. Mindful Eating (ME), which emphasizes awareness and appreciation of eating behaviors, effectively addresses disordered eating behaviors. However, there are still many cases of DE among collage students, especially women. This research aimed to develop a canvas-based animation video to help college students overcome DE. The type research method in this study used Research and Development (R&D) with the ADDIE (Analyze, Design, Development, Implementation, and Evaluation) model, but only up to the development stage in this study. Canva-based animation video validation involves three experts: expert materials, linguists, and media experts, with an average result of 80.3 (decent category, revised as necessary). Next, it was tested on prospective users (n = 37) who were selected by simple random sampling. The results of product assessment by prospective users amounted to 91.1 (very feasible category, no need to revise). The ME Knowledge Questionnaire measured the impact of video use (reliability = 0.621). The results of the comprehension score based on the pre-test and post-test on students obtained an average N-Gain score of 0.84 with an average score of 0.84 with a high category. Based on the analysis results, it can be concluded that ME video products are feasible to use as learning media to increase ME knowledge and overcome ED problems in collage students.
EFFECTS OF ANNONA GLABRA LEAF (Annona Glabra) EXTRACT ADDITION ON GROWTH, SURVIVAL RATE, AND ANTISERUM ACTIVITY AGAINST Edwardsiella ictalurid BACTERIA, INDUCING HEPATITIS AND KIDNEY DISEASE IN CATFISH (Pangasianodon hypophthalmus)
Authors: Linh Nguyễn Thị Trúc , Bích Trần Thị Ngọc , Đầy Phạm Văn , Nguyên Phạm Thị Bình 
Published: October 2024

Nghiên cứu được thực hiện nhằm đánh giá ảnh hưởng chất chiết lá bình bát (Annona glabra) lên tăng trọng, tỷ lệ sống và hoạt tính kháng khuẩn huyết thanh chống lại vi khuẩn Edwardsiella ictalurid, gây bệnh gan thận mủ trên cá tra (Pangasianodon hypophthalmus). Thí nghiệm được bố trí hoàn toàn ngẫu nhiên với 3 lần lặp lại ở các nồng độ 1%, 1,5% và 2% chất chiết lá bình bát trong 30 ngày. Xác định tốc độ tăng trưởng của cá với tần suất 10 ngày/lần, tỷ lệ sống của cá được xác định sau khi kết thúc thí nghiệm và hoạt tính kháng khuẩn huyết thanh của cá được thu mẫu ở ngày đầu trước bố trí, ngày 15 và ngày 30. Kết quả cho thấy việc bổ sung chất chiết lá bình bát đã không làm ảnh hưởng đến tỷ lệ sống bình thường của cá thí nghiệm, tốc độ tăng trưởng về trọng lượng và chiều dài được cải thiện đáng kể và khác biệt có ý nghĩa thống kê so với đối chứng ở 30 ngày thí nghiệm. Hoạt tính kháng khuẩn huyết thanh gia tăng ở các nghiệm thức bổ sung chất chiết lá bình bát so với đối chứng (p<0,05). Những khả năng này của chất chiết lá bình bát có thể được sử dụng làm chất bổ sung cho cá tra.
MÔ HÌNH SÀNG LỌC ẢO BẰNG PHƯƠNG PHÁP HỌC MÁY VÀ MÔ PHỎNG TƯƠNG TÁC PHÂN TỬ NHẰM PHÁT HIỆN CÁC HỢP CHẤT CÓ KHẢ NĂNG ỨC CHẾ HOẠT ĐỘNG ENZYM POLY ADP-RIBOSE POLYMERASE 1 THÔNG QUA VIỆC TÁI SỬ DỤNG THUỐC
Authors: Linh Trần Thị Thùy , Lan Nguyễn Thị Mỹ , Quyên Nguyễn Thị Tố , Thu Trần Thị Hoài , Thi Nguyễn Hoàng Trang , Khanh Nguyễn Tấn 
Published: October 2024

Poly ADP-ribose Polymerase 1 (PARP1) là enzym đóng vai trò quan trọng trong việc sửa chữa DNA, phiên mã và tái cấu trúc nhiễm sắc thể của tế bào. Việc tăng biểu hiện của PARP1 cho thấy sự liên quan đến việc ức chế sự phát triển của nhiều dòng tế bào ung thư khác nhau. Trong nghiên cứu này, hai phương pháp sàng lọc bao gồm xây dựng mô hình học máy và mô phỏng tương tác phân tử được sử dụng nhằm đưa ra mô hình có khả năng phát hiện các hợp chất có thể gắn kết trực tiếp vào PARP1, qua đó ức chế hoạt động của enzym. Kết quả cho thấy mô hình LightGBM Classifier có độ chính xác lên đến 88% trong việc phân loại các hợp chất có khả năng ức chế hoạt động của PARP1. Kết quả mô phỏng tương tác phân tử phát hiện bốn hợp chất tiềm năng có khả năng gắn kết trực tiếp vào tâm xúc tác của enzym PARP1 bao gồm idelalisib, capmatinib, duvelisib và tecovirimat với ái lực liên kết lần lượt là -11,96 kcal/mol, -11,72 kcal/mol, -11,54 kcal/mol và -11,04 kcal/mol. Để đánh giá quá trình docking, phương pháp giả lập động lực học phân tử được áp dụng với khoảng thời gian 100 ns. Kết quả của nghiên cứu đưa ra một mô hình sàng lọc mới, có độ tin cậy cao trong việc phát hiện các hợp chất có khả năng ức chế hoạt động của PARP1, đồng thời, chỉ ra các hợp chất tiềm năng có thể phát triển thành thuốc điều trị ung thư thông qua cơ chế gắn kết trực tiếp vào enzym PARP1.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//