bluuebunny/crossref_metadata_2025_split huggingface dataset:
Better Oral Hygiene Habits Are Associated With a Lower Incidence of Peritoneal Dialysis‐Related Peritonitis
Authors: Oka Hideaki , Yamada Shunsuke , Kamimura Taro , Aihara Seishi , Hyodo Masahide , Terakado Nagaaki , Harada Atsumi , Nakano Toshiaki , Tsuruya Kazuhiko , Kitazono Takanari 
Published: October 2018

AbstractSome peritoneal dialysis (PD)‐related peritonitis cases are thought to be caused by the pathogens in the oral cavity; however, the relationship between peritonitis and oral hygiene habits is unclear. In this study, we retrospectively examined the relationship between oral hygiene habits and peritonitis in patients who agreed to a questionnaire survey. Of the 75 patients, 37 patients developed PD‐related peritonitis during the observation period. Peritonitis‐free survival was significantly higher in patients who spent more time on oral hygiene daily and in patients who replaced their toothbrush more frequently (P < 0.05). According to multivariable analysis, increased daily oral hygiene duration and more frequent toothbrush replacement were associated with a significantly (P < 0.01) lower risk for peritonitis (hazard ratio [HR] 0.37 [95% CI, 0.18–0.77] and HR 0.35 [95% CI, 0.17–0.70], respectively). In conclusion, PD patients with superior oral hygiene habits showed a lower risk for PD‐related peritonitis.
McSwan: A joint site frequency spectrum method to detect and date selective sweeps across multiple population genomes
Authors: Tournebize Rémi , Poncet Valérie , Jakobsson Mattias , Vigouroux Yves , Manel Stéphanie 
Published: October 2018

AbstractInferring the mode and tempo of natural selection helps further our understanding of adaptation to past environmental changes. Here, we introduce McSwan, a method to detect and date past and recent natural selection events in the case of a hard sweep. The method is based on the comparison of site frequency spectra obtained under various demographic models that include selection. McSwan demonstrated high power (high sensitivity and specificity) in capturing hard selective sweep events without requiring haplotype phasing. It performed slightly better than SweeD when the recent effective population size was low and the genomic region was small. We then applied our method to a European (CEU) and an African (LWK) human re‐sequencing data set. Most hard sweeps were detected in the CEU population (96%). Moreover, hard sweeps in the African population were estimated to have occurred further back in time (mode: 43,625 years BP) compared to those of Europeans (mode: 24,850 years BP). Most of the estimated ages of hard sweeps in Europeans were associated with the Last Glacial Maximum and were enriched in immunity‐associated genes.
The change in the value relevance of accounting information after mergers and acquisitions: evidence from the adoption of SFAS 141(R)
Authors: Kwon Shin Hyoung , Wang Guannan 
Published: October 2018

AbstractThis study examines how and why investors change the use of their information sources in valuation between book value and earnings after mergers and acquisitions (M&A) in both pre‐ and post‐SFAS 141(R) periods. We find that investors generally put less weight on earnings but more weight on book value after M&A than before M&A, and that such a change is particularly strong after the adoption of SFAS 141(R). By looking at goodwill, other intangible assets and other balance sheet accounts that SFAS 141(R) amended, we further find that SFAS 141(R) improves the value relevance of book value components after M&A.
Gender differences and similarities in aggression, suicidal behaviour, and psychiatric comorbidity in borderline personality disorder
Authors: Sher L. , Rutter S. B. , New A. S. , Siever L. J. , Hazlett E. A. 
Published: October 2018

ObjectiveWe examined gender differences and similarities in aggression, impulsivity, suicidal behaviour, and psychiatric comorbidity in men and women with borderline personality disorder (BPD) compared with healthy controls.MethodA community sample of 511 participants (healthy controls: 81 men and 82 women; BPD patients: 145 men and 203 women) were rigorously characterized using structured diagnostic interviews and symptom severity assessments.ResultsIn comparison with women with BPD, men were less educated, had higher total Barratt Impulsivity Scale (BIS), BIS—motoric impulsiveness and BIS—non‐planning impulsiveness subscale, total Buss–Perry Aggression Questionnaire (BPAQ), and BPAQ—physical aggression subscale scores. Men with BPD were more likely to have comorbid narcissistic, antisocial, paranoid, and schizotypal personality disorders, alcohol and substance use disorders but less likely to have dependent and obsessive–compulsive personality disorders compared to women with BPD. There was a trend toward higher maximum lethality of suicide attempts in men suicide attempters compared with women suicide attempters but no difference between men and women with regard to the proportion of suicide attempters or the number of suicide attempts.ConclusionMen with BPD are more impaired and may be at higher risk of dying by suicide compared to women with BPD.
The clinical usefulness of a novel grading system for varicocoeles using duplex Doppler ultrasound examination based on postsurgical modifications of seminal parameters
Authors: Cavallini G. , Scroppo F. I. , Colpi G. M. 
Published: October 2018

AbstractBackgroundThe existing classifications of varicocoeles have poor predictive value regarding the effects of surgery on sperm count.ObjectiveTo develop a new grading system for varicocoeles, useful as an indication for surgery.Materials and methodsThis is a three‐center prospective study which examined 173 men having clinically detectable left varicocoeles and oligo ± astheno ± terato‐spermia. The patients underwent medical history collection, objective examination, duplex Doppler ultrasound scrotal examination, hormonal profiles, two semen analyses before surgery, and two semen analyses after surgery. Sperm concentration, motility, and morphology (standard semen parameters) were evaluated 6 months after surgery in function of the following preoperative variables: patient age, follicle‐stimulating hormone, clinical grade of varicocoele, right and left testicular volume, extension of venous reflux, and semen parameters. The venous reflux was graded in two centers using duplex Doppler ultrasound: reflux visible only with Valsalva and continuous reflux. Spearman's rank semiquantitative analysis was used. All patients had their varicocoeles corrected according to the Colpi technique.ResultsThe variables capable of determining an improvement in semen parameters after varicocoele correction were in order of decreasing importance: venous reflux extent assessed by scrotal duplex Doppler ultrasound examination, varicocoele clinical grade, basal semen parameters, and follicle‐stimulating hormone. Male age did not influence postoperative semen quality. Only patients with continuous reflux had their standard semen parameters improved after surgery.DiscussionVenous reflux extent is the most critical variable capable of predicting semen improvement after varicocoelectomy.ConclusionsA correct duplex Doppler assessment of venous reflux is mandatory for predicting postoperative improvement of the sperm count.
Metabolic syndrome and some of its components in relation to risk of cataract extraction. A prospective cohort study of men
Authors: Lindblad Birgitta Ejdervik , Håkansson Niclas , Wolk Alicja 
Published: October 2018

AbstractPurposeTo evaluate the relationship between metabolic syndrome and some of its components with the incidence of cataract extraction.MethodsA population‐based prospective cohort with a total of 45 049 men, aged 45–79 years, from the Cohort of Swedish Men completed in 1997 a self‐administered questionnaire concerning anthropometric measurements and lifestyle factors. The men were followed from 1 January 1998 through 31 December 2012, and the cohort was matched with registers of cataract extraction. The main outcome measure was incident cases of age‐related cataract extraction.ResultsOver the 15‐years of follow‐up, 7573 incident cases of cataract extraction were identified. After controlling for potential confounders, the association between single components of metabolic syndrome, abdominal adiposity, diabetes and hypertension and risk of cataract extraction was rate ratio (RR): 1.04; 95% confidence interval (CI): 0.99–1.10, RR: 1.77; 95% CI: 1.64–1.92 and RR: 1.06; 95% CI 1.00–1.13, respectively. The risk of cataract extraction increased with increasing numbers of metabolic syndrome components (p < 0.0001). Men aged 65 years or younger at baseline with all three components of the metabolic syndrome had a relative risk of 2.43 (95% CI: 1.95–3.01) for cataract extraction.ConclusionIn this cohort of middle‐aged and elderly men, metabolic syndrome with the combination of abdominal adiposity, diabetes and hypertension was associated with an increased risk for cataract extraction, especially among men aged 65 years or younger. These findings put emphasis on the importance of weight control and healthy lifestyle behaviours in order to prevent cataract.
Justice versus fairness in the family business workplace: A socioemotional wealth approach
Authors: Samara Georges , Paul Karen 
Published: October 2018

AbstractThe organizational justice literature and the family business literature have developed independently, which limits our understanding of fairness and justice in the family business workplace. So far, the concepts of justice and fairness have been used interchangeably in the family business literature, as if objective measures that aim to increase justice in the workplace will automatically translate into fairness perceptions among family business employees. By integrating the organizational justice literature and the family business literature, we first differentiate between the two concepts of justice and fairness and argue that a utilitarian conceptualization of justice may come into direct conflict with fairness perceptions in the family business workplace. Second, we shed light on the importance of incorporating socioemotional goals, particularly those that reveal a bright side of socioemotional wealth, into rules and regulations designed to increase justice in the workplace, which, we argue, contributes to increasing fairness perceptions among employees and to building and maintaining an ethical family business workplace. Theoretical and practical contributions are discussed at the end of the paper.
Automated Feature Selection of Predictors in Electronic Medical Records Data
Authors: Gronsbell Jessica , Minnier Jessica , Yu Sheng , Liao Katherine , Cai Tianxi 
Published: October 2018

AbstractThe use of Electronic Health Records (EHR) for translational research can be challenging due to difficulty in extracting accurate disease phenotype data. Historically, EHR algorithms for annotating phenotypes have been either rule-based or trained with billing codes and gold standard labels curated via labor intensive medical chart review. These simplistic algorithms tend to have unpredictable portability across institutions and low accuracy for many disease phenotypes due to imprecise billing codes. Recently, more sophisticated machine learning algorithms have been developed to improve the robustness and accuracy of EHR phenotyping algorithms. These algorithms are typically trained via supervised learning, relating gold standard labels to a wide range of candidate features including billing codes, procedure codes, medication prescriptions and relevant clinical concepts extracted from narrative notes via Natural Language Processing (NLP). However, due to the time intensiveness of gold standard labeling, the size of the training set is often insufficient to build a generalizable algorithm with the large number of candidate features extracted from EHR. To reduce the number of candidate predictors and in turn improve model performance, we present an automated feature selection method based entirely on unlabeled observations. The proposed method generates a comprehensive surrogate for the underlying phenotype with an unsupervised clustering of disease status based on several highly predictive features such as diagnosis codes and mentions of the disease in text fields available in the entire set of EHR data. A sparse regression model is then built with the estimated outcomes and remaining covariates to identify those features most informative of the phenotype of interest. Relying on the results of Li and Duan (1989), we demonstrate that variable selection for the underlying phenotype model can be achieved by fitting the surrogate-based model. We explore the performance of our methods in numerical simulations and present the results of a prediction model for Rheumatoid Arthritis (RA) built on a large EHR data mart from the Partners Health System consisting of billing codes and NLP terms. Empirical results suggest that our procedure reduces the number of gold-standard labels necessary for phenotyping thereby harnessing the automated power of EHR data and improving efficiency.
Structure‐based pharmacophore models to probe anticancer activity of inhibitors of protein kinase B‐beta (PKB β)
Authors: Akhtar Noreen , Jabeen Ishrat , Jalal Nasir , Antilla Jon 
Published: October 2018

AbstractProtein kinase B‐beta (PKBβ/Akt2) is a non‐receptor kinase that has attracted a great deal of attention as a promising cancer therapy drug target. In mammalian cells, hyperactivation of Akt2 exclusively facilitates the survival of solid tumors by interfering with cell cycle progression. This definite function of Akt2 in tumor survival/maintenance provides the basis for the development of its antagonists with the aim of desensitizing cell proliferation. In order to find novel and potent Akt2 inhibitors, structure‐based pharmacophore models have been developed and validated by the test set prediction. The final pharmacophore model was used for hits identification using public chemical databases. The hits were further prioritized using drug‐like filters which revealed 14 potential hit compounds having novel chemical scaffolds. Our results elucidate the importance of three hydrogen bond acceptors (A), one hydrogen bond donor (D), one hydrophobic group (H), and one positive ionic charge (P) toward inhibition of the Ak2. One of our selected hits showed 68% cell apoptosis at 8 μg/ml concentration. We proposed various chemical scaffolds including benzamide, carboxamide, and methyl benzimidazole targeting Akt2 and thus may act as potential leads for the further development of new anticancer agents.
Median momentum
Authors: Chen Tsung‐Yu , Chou Pin‐Huang 
Published: October 2018

AbstractThe median is a better measure of a sample's central tendency in the presence of extreme observations. We propose an alternative momentum strategy formed by buying (shorting) stocks with high (low) average median returns over a formation period of 3–12 months. The median momentum strategy outperforms the traditional price momentum strategy for all holding periods from 1 month to 5 years, with no long‐term reversal. This same return pattern is observed for all G7 countries. Further analysis indicates that median momentum profitability is an underreaction‐only phenomenon and shows behavioral patterns related to short‐sale restrictions and investor sentiment.
Systematic review and meta‐analysis of anti‐hyperglycaemic effects of Pu‐erh tea
Authors: Lin Hsin‐Cheng , Lee Chien‐Tai , Yen Yea‐Yin , Chu Chiao‐Lee , Hsieh Yen‐Ping , Yang Chi‐Sheng , Lan Shou‐Jen 
Published: October 2018

SummaryPu‐erh tea was presumed to have anti‐hyperglycaemic effects with limited evidence. This study uses meta‐analysis to investigate anti‐hyperglycaemic effect of Pu‐erh tea. Five English databases and three Chinese ones were systematically searched up to July 31, 2018. Those databases were searched to identify studies containing keywords of ‘Pu‐erh’, ‘Pu'er’, ‘blood sugar’, ‘blood glucose’ and ‘hyperglycaemia’. RevMan 5 and Stata were then utilized to conduct meta‐analysis. Systematic reviews collected two mice studies with sixteen records for meta‐analysis. Meta‐analysis results showed that Pu‐erh tea has significant anti‐hyperglycaemic effect on mice. Pooled weight mean difference of blood sugar on mice studies were 71 and 116 mg dL−1 at 21st day and 28th day respectively. Meta‐regression disclosed over a longer intervention period showed that Pu‐erh tea can reduce fasting blood glucose. Secondly, a higher dose of Pu‐erh is shown to lower fasting blood glucose more significantly.
Polymorphism of the programmed death‐ligand 1 gene is associated with its protein expression and prognosis in gastric cancer
Authors: Wu Yanhua , Zhao Tiancheng , Jia Zhifang , Cao Donghui , Cao Xueyuan , Pan Yuchen , Zhao Dan , Zhang Bin , Jiang Jing 
Published: October 2018

AbstractBackground and AimWhile the incidence and mortality of gastric cancer (GC) remains high, and prognosis of GC remains poor, molecules in programmed death‐1 (PD‐1), programmed death‐ligand 1 (PD‐L1), and programmed death‐ligand 2 (PD‐L2) pathway are promising prognostic biomarker of GC. The polymorphisms on PD‐1, PD‐L1, and PD‐L2 may be associated with their protein expressions and affect the survival of GC patient.MethodsSeven hundred fifty‐six GC patients who voluntarily supplied blood samples were enrolled in our study. We genotyped nine polymorphisms on PD‐1, PD‐L1, and PD‐L2, then evaluated the association of the single nucleotide polymorphisms with GC prognosis and analyzed the relationship between the PD‐1, PD‐L1, and PD‐L2 single nucleotide polymorphism genotypes and their protein expression.ResultsWe found that PD‐L1 rs822336 CC genotype was independently associated with a better survival of all GC patients and those without postoperative chemotherapy (hazard ratio [HR] = 0.504, 95% confidence interval [CI] = 0.283–0.897 and HR = 0.385, 95% CI = 0.189–0.786). AA+AG genotype of rs2297136 in 3'UTR of the PD‐L1 was correlated with the protein expression of PD‐L1 protein both in patients overall and those without postoperative chemotherapy (P = 0.013 and P = 0.012). AA+AG genotype of rs2297136 served as an independent factor of better prognosis in patients without postoperative chemotherapy (HR = 0.348, 95% CI = 0.125–0.968).ConclusionsOverall, PD‐L1 polymorphisms and protein expression were associated with the prognosis of patients with GC.
Prosthetic Rehabilitation with Palatal Lift/Augmentation in a Patient with Neurologic/Motor Deficit Due To Cancer Therapy for Chondrosarcoma
Authors: Asfar Midhat M. , Hutcheson Katherine A. , Won Alexander M. 
Published: October 2018

AbstractThis clinical report describes the prosthetic rehabilitation of a 25‐year‐old man with a history of grade II chondrosarcoma at the skull base who had undergone surgical resection and thereafter developed velopharyngeal incompetency (VPI), dysarthria, and dysphagia. Upon baseline fiberoptic endoscopic evaluation of swallowing (FEES), the patient had an atypical pattern of VPI with minimal to no velar lift during speech, blow, or suck tasks, but near complete velar lift and seal during swallowing. A palatal augmentation prosthesis combined with a resilient palatal lift extension was fabricated to enhance speech by displacing the soft palate and to decrease hypernasality, while avoiding interference with bolus transport. A resilient wrought wire extension was necessary to accommodate the velar movement upon swallowing while keeping the integrity of the velar lift during speech. In conclusion, this unique combination prosthesis was able to help the patient's atypical pattern of VPI by improving speech and preserving swallowing function, which was confirmed during a post‐endoscopic evaluation.
Effects of dietary sorghum dried distiller's grains with solubles on growth performance, diet nutrient digestibility, carcass characteristics and immunity in growing rabbits
Authors: Yang Yanhong , Shen Yingchun , Pan Yuanqing , Xia Pei , Zhang Deguang , He Zhifei , Yang Jiqiong , Li Hongjun , Lu Jingzhi 
Published: October 2018

AbstractSorghum dried distiller's grains with solubles (S‐DDGS) are distillation extract residues from the ethanol fuel industry. In this experiment, two hundred 42‐day‐old rabbits were randomly allocated to five experimental diets containing 0 g/kg (control), 75, 150, 225 and 300 g/kg S‐DDGS. The experiment lasted for 4 weeks. No difference was found in the average daily feed intake (ADFI; p > 0.05). With increasing sorghum inclusion, the average daily gain (ADG) was linearly (p < 0.001) and quadratically (p = 0.039) reduced, while, conversely, the feed conversion ratio (FCR) linearly (p < 0.001) increased. Increasing the amount of S‐DDGS in the diet linearly decreased (p < 0.001) the apparent total tract digestibility (ATTD) of dry matter (DM), organic matter (OM), crude protein (CP) and ash. Carcass weight, carcass yield, heart and liver weights were linearly decreased by an increase in the amount of S‐DDGS added to diets (p < 0.001), but no difference was observed between the 0, 75 and 150 g/kg S‐DDGS groups (p > 0.05). Serum IL‐6, IL‐10 and SIgA linearly increased (p = 0.008) with increasing levels of S‐DDGS in the diet. Rabbits fed 0, 75 and 150 g/kg of S‐DDGS had similar IL‐6 and IL‐10 levels. Statistically significant differences in SIgA were observed between rabbits fed control diets and feed mixtures containing S‐DDGS (p < 0.01). To conclude, S‐DDGS can safely be added up to 75 g/kg, to the diet of rabbits. Increasing dietary S‐DDGS inclusion may decrease the growth performance, nutrient digestibility and carcass traits, and activate immune responses.
Social Support and Physical Activity Among American Indians in Oklahoma: Results From a Community‐based Participatory Research Study
Authors: Salvatore Alicia L. , Noonan Carolyn J. , Williams Mary B. , Wetherill Marianna S. , Jacob Tvli , Cannady Tamela K. , Standridge Joy , Grammar Mandy , Fox Jill , Wiley Andina , Spiegel Jennifer , Jernigan Valarie Blue Bird 
Published: October 2018

AbstractPurposeLittle is known about the contribution of social support to physical activity (PA) behavior among American Indians (AIs). This community‐based participatory research study examined the prevalence of and associations between different types of PA social support and PA among AIs in rural Oklahoma.MethodsOur tribal‐academic partnership surveyed AI adults (N = 513) living within the tribal jurisdictional areas of 2 tribal nations. We used the Physical Activity Social Support (PASS) scale to assess 3 types of PA social support and Poisson regression to investigate associations between PASS types and self‐reported PA behavior.FindingsOver a third of participants perceived high levels of PA social support from friends (37%), family (35%), and overall (34%), yet only 29% reported regular PA (ie, 150 minutes or more weekly). Participants who exercised with pets/other were significantly more likely to achieve regular PA than those who exercised alone (PR 2.0, 95% CI: 1.4‐2.9). Although not significant, compared with those reporting no/low support, participants with high friend PASS (PR 1.2, 95%: CI 0.9‐1.6), medium family PASS (PR 1.2, 95% CI: 0.9‐1.7), and overall PASS (PR 1.1, 95% CI: 0.8‐1.6) were more likely to report regular PA.ConclusionsThe majority of participants did not meet current recommendations for PA behavior, which underscores the ongoing need for PA effective interventions among AIs living in rural areas. Results suggest that exercising with pets/other could be an important factor for future intervention. Further research is needed to elucidate determinants of PA and test interventions to increase PA among AIs.