bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electromagnetic side-channel attack risk assessment on a practical quantum-key-distribution receiver based on multi-class classification
Authors: Pantoja John J. , Bucheli Victor A. , Donaldson Ross 
Published: November 2024

AbstractWhile quantum key distribution (QKD) is a theoretically secure way of growing quantum-safe encryption keys, many practical implementations are challenged due to various open attack vectors, resulting in many variations of QKD protocols. Side channels are one such vector that allows a passive or active eavesdropper to obtain QKD information leaked through practical devices. This paper assesses the feasibility and implications of extracting the raw secret key from far-field radiated emissions from the single-photon avalanche diodes used in a BB84 QKD quad-detector receiver. Enhancement of the attack was also demonstrated through the use of deep-learning model to distinguish radiated emissions due to the four polarized encoding states. To evaluate the severity of such side-channel attack, multi-class classification based on raw-data and pre-processed data is implemented and assessed. Results show that classifiers based on both raw-data and pre-processed features can discern variations of the electromagnetic emissions caused by specific orientations of the detectors within the receiver with an accuracy higher than 90%. This research proposes machine learning models as a technique to assess EM information leakage risk of QKD and highlights the feasibility of side-channel attacks in the far-field region, further emphasizing the need to utilise mechanisms to avoid electromagnetic radiation information leaks and measurement-device-independent QKD protocols.
The Application of Computer-Aided Film and Television Art Design Elements in Exhibition Space Design
Authors: Du Jiao 
Published: November 2024

Exhibition spaces are where human civilization is passed along, science and culture are disseminated, and new design concepts and techniques are assimilated to better them over time. Several offline and online exhibitions have been affected, stopped, postponed, or relocated online due to the effect of the outbreak. Presently, the development and enhancement of virtual exhibition halls is underway. Visitors to exposition halls are no longer limited to those from the immediate area; rather, an increasing number of people come from all over the nation and even from other countries. Due to this, pavilions that are equipped with remote tour features become very influential. The cloud exhibition of the film and television art design elements is the focus of this study, and it additionally builds a virtual display platform and presents 3D Imaging and Virtual Reality Technology (3DIVRT). Through the lens of 3D modeling technology and virtual exhibition hall building, this study first investigates the application trend and preliminary practice of digital design in virtual exhibition halls domestically and internationally. A comparison is made between virtual exhibition halls and conventional exhibition halls to summarize the benefits and possibilities of virtual exhibition halls. Second, it elaborates on the features of the 3D experience found in virtual exhibition halls from immersion, interaction, and conceivability perspectives. A fundamental examination and comparison of 3D modeling software is carried out, and Blender and Unity’s impact on the execution of the virtual exhibition hall is detailed. Synchronizing virtual reflection by computational capabilities, which will be identified with certain examples from across the globe, requires multimedia to be successful. Various methods to exhibit activity that uses computer-aided technologies are brought to light in this research study. According to the findings and conclusions, manual presentation and technical distinctions are how artistic and reflective features can be achieved.
Device Reliability of Negative Capacitance Source Pocket Double Gate TFETs: A Study on Temperature and Noise Effects
Authors: Babu K. Murali Chandra , Goel Ekta 
Published: November 2024

This study investigates the reliability of a negative capacitance source pocket double gate tunnel field-effect transistor (NC-SP-DGTFET) by examining the effects of temperature and various noise components on its performance. The research focuses on key DC parameters, including the transfer characteristics, subthreshold swing, and the ION/IOFF ratio, evaluated across a temperature range from 250 to 450 K. Additionally, the study explores the radio-frequency performance of the device by assessing how temperature impacts transconductance (gm), cut-off frequency (fT), gate capacitance (Cgg), intrinsic delay, and the transconductance frequency product. Noise performance metrics are also analyzed, focusing on the drain current noise power spectral density (SID) and gate voltage noise power spectral density (SVG). The study considers the contributions of diffusion, generation-recombination (G-R), and flicker noise components and at 300 K, SID and SVG showed peak values of 5.08 × 10−26 A2/Hz and 2.67 × 10−16 V2/Hz, 5.73 × 10−18 A2/Hz and 3.22 × 10−10 V2/Hz, and 1.33 × 10−25 A2/Hz and 1.19 × 10−14 V2/Hz, respectively. The analysis reveals that flicker noise is predominant at lower frequencies, while diffusion noise becomes more significant at higher frequencies. However, G-R noise is the most dominant across all frequencies examined. These findings provide crucial insights for optimizing the design and performance of NC-SP-DGTFETs in low-power applications.
A3669G Polymorphism of Glucocorticoid Receptor Is More Present in Patients With Pemphigus Vulgaris Than in Healthy Controls and Contributes to Steroid‐Resistance
Authors: Lepekhova Anfisa , Olisova Olga , Shimanovsky Nikolay , Teplyuk Natalia , Zhgelskaya Elizaveta , Punj Ridhima , Mardanova Alina , Dukhanin Alexander 
Published: November 2024

There are two main isoforms of glucocorticoid receptor (GR) α‐ and β‐isoforms. GRβ isoform is the dominant inhibitor of the GRα receptor and plays a significant role in a poor response to systemic glucocorticoids (GCs) under numerous conditions. The A3669G (rs6198) polymorphism (SNP) in the untranslated region of human GR stabilizes the mRNA of the dominant‐negative GRβ isoform. However, the mechanisms which generate mRNA encoding the GRβ isoform have been poorly defined, especially in pemphigus patients who do not respond to GCs. The main aim was to study gene SNP of GR in patients with pemphigus vulgaris (PV) and healthy controls. We investigated whether the A3669G SNP of the human GRβ gene is a susceptibility allele for PV and contributes to GC resistance development. The presence of the A3669G SNP was determined by high‐resolution melting analysis and then confirmed by direct sequencing. GR A3669G SNP (AG genotype) occurred more frequently in PV patients (n = 72; 25%) compared with healthy controls (n = 92; 3.2%; p < 0.001). Allele G was significantly more presented in PV patients (p < 0.001). Out of 48 patients with AA genotype of A3669G SNP, only 6 had GC resistance, whereas 11 out of 18 with AG genotype developed GC resistance (p < 0.0001). The frequency of a poor response to GC in the group of patients with AG genotype was 4.89 times higher compared to AG negative one (p < 0.0001).Our study showed that the A3669G SNP was more present in PV patients. Moreover, GC resistance appeared more frequently in patients with the AG genotype (p < 0.0001). Since those patients predominantly with severe pemphigus had GC resistance (p = 0.001), we feel that A3669G SNP (AG genotype) contributes to its development. However, more studies are needed to determine whether A3669G SNP of the human GR gene associated with the disease severity and poor response to GCs in these patients.
A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional–Structural Hybrid Connectome in Breast Cancer
Authors: Liang Mu Zi , Zhou Jin , Chen Peng , Song Ya Lan , Li Shu Han , Liang Yu Yan , Hu Guang Yun , Hu Qu , Sun Zhe , Yu Yuan Liang , Molassiotis Alex , Knobf M. Tish , Ye Zeng Jie 
Published: November 2024

Purposes: To evaluate the association between psychological resilience, depression disorder (DD), and brain functional–structural hybrid connectome in patients with breast cancer before treatment (T0) and at 1 year.Methods: Between February 2017 and October 2019, 172 patients were longitudinally enrolled from a multicenter trial named as Be Resilient to Breast Cancer (BRBC) and completed resting‐state functional magnetic resonance imaging (rs‐fMRI) and diffusion tensor imaging (DTI) before the T0. Data‐driven multivoxel pattern analysis (MVPA) and correlational tractography (CT) were performed to identify distinct functional‐structural hybrid connectome. DD was diagnosed by psychiatry physicians according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5). Psychological resilience was collected by Resilience Scale Specific to Cancer (RS‐SC) and tested as the mediation variable between hybrid connectome and DD.Results: Of the total sample of 172, 14.5% (N = 25) were diagnosed with DD. High psychological resilience was associated with a lower risk of DD (hazard ratio (HR) = 0.37, 95% confidence interval (CI), 0.17–0.82, p = 0.0368). Frontal pole right (88.0%) in rs‐fMRI and arcuate fasciculus_L (75.2%) in DTI were identified as main significant brain areas. Psychological resilience accounted for 10.01%–12.14% of direct effect between brain functional–structural hybrid connectome and 1‐year DD.Conclusion: Psychological resilience predicts DD at 1 year and mediates the association between brain functional–structural hybrid connectome and DD at 1 year in patients diagnosed with breast cancer.Trial Registration: ClinicalTrials.gov identifier: NCT03026374
Long-Term Efficacy and Safety of Acoramidis in ATTR-CM: Initial Report From the Open-Label Extension of the ATTRibute-CM Trial
Authors: Judge Daniel P. , Gillmore Julian D. , Alexander Kevin M. , Ambardekar Amrut V. , Cappelli Francesco , Fontana Marianna , García-Pavía Pablo , Grodin Justin L. , Grogan Martha , Hanna Mazen , Masri Ahmad , Nativi-Nicolau Jose , Obici Laura , Hvitfeldt Poulsen Steen , Sarswat Nitasha , Shah Keyur , Soman Prem , Lystig Ted , Cao Xiaofan , Wang Kevin , Pecoraro Maria Lucia , Tamby Jean-François , Katz Leonid , Sinha Uma , Fox Jonathan C. , Maurer Mathew S. 
Published: November 2024

Background: In the phase 3 randomized controlled study, ATTRibute-CM, acoramidis, a transthyretin (TTR) stabilizer, demonstrated significant efficacy on the primary endpoint. Participants with transthyretin amyloid cardiomyopathy (ATTR-CM) who completed ATTRibute-CM were invited to enroll in an open-label extension study (OLE). We report efficacy and safety data of acoramidis in participants who completed ATTRibute-CM and enrolled in the ongoing OLE.
Methods: Participants who previously received acoramidis through Month 30 (M30) in ATTRibute-CM continued to receive it (continuous acoramidis), and those who received placebo through M30 were switched to acoramidis (placebo to acoramidis). Participants who received concomitant tafamidis in ATTRibute-CM were required to discontinue it to be eligible to enroll in the OLE. Clinical efficacy outcomes analyzed through Month 42 (M42) included time to event for all-cause mortality (ACM) or first cardiovascular-related hospitalization (CVH), ACM alone, first CVH alone, ACM or recurrent CVH, change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP), 6-minute walk distance (6MWD), serum TTR, and the Kansas City Cardiomyopathy Questionnaire Overall Summary score (KCCQ-OS). Safety outcomes were analyzed through M42.

Results: Overall, 438 of 632 participants in ATTRibute-CM completed treatment and 389 enrolled in the ongoing OLE (263 continuous acoramidis, 126 placebo to acoramidis). The hazard ratio (HR) (95% CI) for ACM or first CVH was 0.57 (0.46, 0.72) at M42 based on a stratified Cox proportional hazards model (
P
-value < 0.0001) favoring continuous acoramidis. Similar analyses were performed on ACM alone and first CVH alone, with HRs (95% CI) of 0.64 (0.47, 0.88) and 0.53 (0.41, 0.69), respectively, at M42. Treatment effects for NT-proBNP and 6MWD also favored continuous acoramidis. Upon initiation of open-label acoramidis in the placebo-to-acoramidis arm there was a prompt increase in serum TTR. Quality of life assessed by KCCQ-OS was well preserved in continuous acoramidis participants compared with the placebo to acoramidis participants. No new clinically important safety issues were identified in this long-term evaluation.

Conclusions: Early initiation and continuous use of acoramidis in the ATTRibute-CM study through M42 of the ongoing OLE study was associated with sustained clinical benefits in a contemporary ATTR-CM cohort, with no clinically important safety issues newly identified.
Projected Changes of Kuroshio in a Warming Climate
Authors: Huang Jo-Hsu , Tseng Yu-Heng , Kuo Yi-Chun 
Published: November 2024

Abstract
The projected changes in the Kuroshio and the associated mechanisms in response to future warming scenarios remain unclear. While some studies propose a negative midlatitude wind stress curl (WSC) tendency could expedite Kuroshio recirculation, others suggest that the isopycnal transport of warmer subtropical mode water (STMW) to the east of the Kuroshio enhances only the velocity in the upper ocean. In the future projections under the shared socioeconomic pathways 5-8.5 (SSP5-8.5) within phase 6 of Coupled Model Intercomparison Project (CMIP6) model ensemble, a consistent enhancement of the Kuroshio along the Japanese coast (JP-Kuroshio) is observed. Particularly, the response of the JP-Kuroshio to WSC changes is more pronounced in high-resolution (HR) models than low-resolution (LR) ones. However, diverse results emerge in the East China Sea (ECS-Kuroshio). While most CMIP6 HR models indicate a reduction of Kuroshio within the upper 1000 m in the ECS-Kuroshio, the ensemble of CMIP6 LR models shows an intensification of Kuroshio within the upper 300 m and a deceleration below, suggesting a consistent baroclinic feature in ECS-Kuroshio. Additional ocean model sensitivity experiments confirm that the WSC influences the Kuroshio throughout the entire water column, particularly below 300 m. Within the upper 300 m, the primary driver of Kuroshio changes is the surface warming, aligning with the STMW mechanism. Moreover, the surface salinity flux may also play an important role in the dynamics of Kuroshio changes.
The effects of controlled acute psychological stress on serum cortisol and plasma metanephrine concentrations in healthy subjects
Authors: Vage Aaron , Gormley Gerard , Hamilton Paul K 
Published: November 2024

Background As cortisol and metanephrine are involved in the stress response, it is often recommended that individuals are relaxed at the time of venepuncture, however, evidence behind these recommendations is lacking. We investigated the effects of acute psychological stress on serum cortisol and plasma metanephrine concentrations in healthy individuals exposed to varying levels of psychological stress and compared these results to self-reported measures of stress. Methods Ten medical students completed two medical in-person simulations (one low-complexity, one high-complexity) in a random order. At four times, participants completed the State-Trait Anxiety Inventory (STAI) and serum cortisol and plasma metanephrine/normetanephrine were tested. Results Median (interquartile range) STAI prior to the low-complexity simulation was 44 (18) versus 33 (13) afterwards ( P = 0.050). STAI prior to the high-complexity simulation was 33 (10) versus 48 (17) afterwards ( P = 0.007). Cortisol prior to the low-complexity simulation was 272 nmol/L (115) versus 247 (115) afterwards ( P = 0.333). Prior to the high-complexity simulation, cortisol was 246 (70) versus 261 (137) afterwards ( P = 0.859). Metanephrine prior to the low-complexity simulation was 242 pmol/L (79) versus 247 (93) afterwards ( P = 0.515). Metanephrine prior to the high-complexity simulation was 220 (81) versus 251 pmol/L (120) afterwards ( P = 0.074). Normetanephrine prior to the low-complexity simulation was 593 pmol/L (247) versus 682 (281) afterwards ( P = 0.047 for the difference). Normetanephrine prior to the high-complexity simulation was 696 (123) versus 705 pmol/L (224) afterwards ( P = 0.169). Conclusions The trend in cortisol levels largely reflected changes in STAI. We outline some implications of these findings for current practice and future research.
Co-designing digital mental health interventions with young people: 10 recommendations from lessons learned in low-and-middle-income countries
Authors: Gonsalves Pattie P , Ansari Salik , Berry Clio , Gonsalves Faith , Iyengar Sonaksha , Kashyap Priyambada , Mittal Dhriti , Pal Sweta , Razdan Eshita , Michelson Daniel 
Published: November 2024

Background: Youth-focused co-design, involving active collaboration between researchers, designers, clinicians and end users, is essential for enhancing the acceptability, feasibility and effectiveness of digital mental health interventions (DMHIs). However, most literature on co-design comes from high-income countries and offers limited contextually relevant guidance to programme and intervention developers in low- and middle-income countries (LMICs). Aims: This paper presents 10 recommendations drawn from the co-authors’ experiences of co-designing youth-focused DMHIs as researchers, public engagement specialists and youth advisors. Methods: The recommendations emphasise key aspects of the co-design process including the use of conceptual frameworks, the involvement of diverse youth groups, contextual considerations, and the promotion of young people’s safety and well-being. Results: The recommendations highlight strategies and examples for involving young people, the importance of acknowledging young people’s contributions and evaluating experiences of co-design to improve the overall effectiveness and relevance of DMHIs in LMICs. Conclusion: By implementing these recommendations, DMHI developers can foster more effective and inclusive co-design processes that better meet the needs of young people in LMIC contexts.
Descriptive analysis of MC4R gene variants associated with obesity listed on ClinVar
Authors: Bayhaghi Giti , Karim Zubair A. , Silva Jeane 
Published: November 2024

Objectives The most recent version of ClinVar was utilized to filter variants of the MC4R gene based on location, condition, and clinical significance with the goal of obtaining benign and disease-associated variants of the MC4R gene. MC4R gene variants can lead to dysregulation of energy expenditure and appetite control, which prompted this study to delineate the distinctive features of MC4R gene variants submitted to the ClinVar repository regarding their association with obesity and related phenotypes. Method A thorough search was conducted in the ClinVar repository for clinically significant MC4R variants through the utilization of the gene name MC4R[gene] and MeSH terms “MC4R[gene]” and “single gene"[properties]” in the search box. Leading to the identification of clinically significant genetic variants associated with obesity. Results Utilizing the ClinVar clinical significance ranking system, the MC4R variants were categorized into six groups based on ClinVar/ClinGen's ranking system: pathogenic (P), likely pathogenic (LP), variant of uncertain significance (VUS), benign (B), likely benign (LB), and conflicting classifications (CC). A total of 103 pathogenic variants were observed. These variants have different clinical significance that are associated with monogenic obesity, monogenic diabetes, and body mass index quantitative traits. It was observed that over 80% of the mutations were single nucleotide variants, with nearly half being missense mutations spread throughout the topological and transmembrane domains. Furthermore, TM7 had the highest number of single nucleotide missense mutations. Conclusion Further analysis of the relationships between monogenic obesity and diabetes requires additional investigation to discover the underlying causes of these conditions. The study findings imply that mutations in MC4R's topological and transmembrane regions may significantly influence receptor activation and signaling. As more MC4R variants are discovered and their correlation with obesity is established, there is potential to definitively establish a strong connection between MC4R pathogenic variants and the development of obesity.
Anatomical insights into medial-sided talar dome osteochondral lesions: a comparative analysis of unilateral and bilateral cases and healthy controls using MRI measurements
Authors: Cingoz Eda , Comert Rana Gunoz , Cingoz Mehmet , Yilmaz Ravza , Dursun Memduh 
Published: November 2024

Background The etiology of medial-sided talar osteochondral lesions (OCLs) remains insufficiently understood. Purpose To identify anatomical risk factors contributing to the development of unilateral or bilateral OCL of the talus on the medial side, utilizing morphological parameters derived from magnetic resonance imaging (MRI). Material and Methods In this retrospective study, 24 ankle MRI scans from 12 patients exhibiting bilateral OCLs of the talar dome on the medial side, 24 ankle MRIs from 24 patients with unilateral medial-sided OCLs, and 24 healthy controls matched for age, sex, and side within each group were analyzed. Six distinct MRI parameters were measured: the anterior opening angle of the talus (AOT); tibial axis-medial malleolus angle (TMM); plafond-malleolar angle (PMA); anterior talofibular ligament-posterior talofibular ligament (ATFL-PTFL) angle; the ratio of the distal tibial articular surface to the length of the trochlea tali arc (TAS/TAL); and the depth of the incisura fibularis (IncDep). Results The AOT, ATFL-PTFL angle, and TMM of individuals in both the bilateral and unilateral groups were significantly higher when compared to the healthy controls. In addition, TMM measurements in the unilateral group were significantly higher than in the bilateral group. Conclusion AOT and TMM appeared to be the primary predisposing factors in the development of both unilateral and bilateral OCLs. Furthermore, TMM shows a greater increase in unilateral OCL cases compared to bilateral OCL cases. The fact that TMM is not significantly high in known unilateral OCL cases can be a stimulus for investigating the other ankle for OCL.