bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tibial Tubercle Osteotomy and Medial Patellofemoral Ligament Imbrication for Patellar Instability Due to Trochlear Dysplasia
Authors: Hodax Jonathan D. , Leathers Michael P. , Ding David Y. , Feeley Brian T. , Allen Christina R. , Ma C. Benjamin , Zhang Alan L. 
Published: August 2019

Background: The treatment of patellar instability in the setting of trochlear dysplasia is challenging. Purpose/Hypothesis: The purpose of this study was to evaluate outcomes for the treatment of recurrent patellar dislocations due to trochlear dysplasia using anteromedialization tibial tubercle osteotomy combined with medial patellofemoral ligament (MPFL) imbrication. We hypothesized that the treatment of patellar instability with tibial tubercle osteotomy and MPFL imbrication would result in improved patient satisfaction and decrease patellar instability events in patients with prior instability and trochlear dysplasia. Study Design: Case series; Level of evidence, 4. Methods: We performed a retrospective analysis of patients who underwent MPFL imbrication and concomitant anteromedialization tibial tubercle osteotomy for recurrent patellofemoral instability at a single institution. The minimum follow-up was 1 year. Patient demographic information including age at the time of surgery, sex, body mass index (BMI), tibial tubercle–trochlear groove (TT-TG) distance, and grade of trochlear dysplasia was collected along with relevant operative data. Postoperatively, recurrent dislocation events as well as Knee injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index, and Kujala scores were collected, and satisfaction was ascertained by asking patients whether they would undergo the procedure again. Results: A total of 37 knees from 31 patients (23 female) with a mean follow-up of 3.8 years (range, 1-8.9 years) were included. The mean patient age was 28.8 years (range, 14-45 years), the mean BMI was 24 kg/m2 (range, 20-38 kg/m2), and the mean preoperative TT-TG distance was 18.9 mm (range, 8.4-32.4 mm). Two knees were classified as low-grade trochlear dysplasia (Dejour A) and 35 as high-grade trochlear dysplasia (Dejour B-D). At final follow-up, patients reported mean KOOS subscale scores of 86.5 (Pain), 79.8 (Symptoms), 93.9 (Activities of Daily Living), 74.3 (Sports/Recreation), and 61.9 (Quality of Life), as well as a mean Kujala score of 81.3. Mean patient satisfaction was 8.3 of 10. The majority of knees (86.5%; 32/37) remained stable without recurrent instability after this procedure, while 13.5% (5 knees) suffered a recurrent dislocation, with 2 requiring revision surgery. Eight knees (21.6%) underwent subsequent hardware removal. Conclusion: Anteromedialization tibial tubercle osteotomy with MPFL imbrication can improve recurrent patellofemoral instability and provide significant clinical benefit to patients with trochlear dysplasia.
Intense Therapeutic Ultrasound for Pain Relief in the Treatment for Chronic Plantar Fasciopathy
Authors: Slayton Michael H. , Baravarian Bob , Amodei Richard C. , Compton Keegan B. , Christensen Dallin Neil , McNelly Ashley , Latt L. Daniel 
Published: August 2019

Background: Intense therapeutic ultrasound (ITU) is an innovative ultrasound-based therapy where sound waves are concentrated into select musculoskeletal tissue. These focused waves generate thermal coagula at a controlled depth and space while preserving surrounding tissues. A multicenter study was conducted evaluating the efficiency, safety, and patient tolerance of ITU for the treatment of chronic plantar fasciitis (CPF) pain. Methods: Seventy-four CPF patients, having failed conservative and/or minimally invasive treatment, participated in the study. Randomized participants either received 2 ITU treatments or 2 sham ITU treatments in addition to standard-of-care therapy. Plantar fascia pain was assessed pretreatment and at 4, 8, 12, and 26 weeks after treatment. Diagnostic ultrasonographic images were analyzed to examine hypoechoic, perifascial lesions whose volumes were calculated until week 12. Function and patient satisfaction were measured using self-reported outcome measures. Results: The treated group reported significant average pain reduction (–26%, –33%, –43%) and hypoechoic lesion volume (–33%, –53%, –68%) at weeks 4, 8, and 12 compared to baseline. Although the control/sham group reported insignificant pain changes at the same time points (–5%, +8%, and +2%) and increased hypoechoic lesion volume (+15%, +28%, +58%). Treated patients reported a significant increase in daily living activities (+28%, +42%, +47%, +40%) compared to the sham/control group (+0.12%, +12%, +3%, +21%). Patient satisfaction remained more than 80% at weeks 8, 12, and 26 for all treatment groups. Conclusion: ITU is an effective pain relief treatment for CPF, which is refractory to either conservative measures or minimally invasive treatments. Level of Evidence: Level II.
The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance
Authors: Agger Karl , Nishimura Koutarou , Miyagi Satoru , Messling Jan-Erik , Rasmussen Kasper Dindler , Helin Kristian 
Published: August 2019

Abstract
KDM4 and JMJD2 are histone demethylases that are considered promising targets for treatment of MLL translocation–bearing acute myeloid leukemia. Agger and colleagues demonstrate an important role of KDM4 activity in long-term normal hematopoiesis that should be considered when contemplating the clinical use of long-term inhibition of KDM4 demethylase activity.
Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis
Authors: Cook Elina K. , Izukawa Terumi , Young Sherylan , Rosen Gili , Jamali Mina , Zhang Liying , Johnson Dylan , Bain Eva , Hilland Jamie , Ferrone Christina K. , Buckstein Jonah , Francis Janika , Momtaz Bushra , McNaughton Amy J. M. , Liu Xudong , Snetsinger Brooke , Buckstein Rena , Rauh Michael J. 
Published: August 2019

Key Points
CH may be associated with broader ill health (worse performance status, increased and potentially novel comorbidities). Serum interleukin-6 is elevated in people with CH and genetic subtypes, providing a view of the human systemic inflammatory landscape of CH.
Estimating changes in seismic wave velocity from a pneumatic source in an operational mine
Authors: Salmon Brian P. , Goldswain Gareth , Lynch Richard A. , Rebuli Daryl , Olivier Jan C. , Kleynhans Waldo 
Published: August 2019

Rock mass characteristics such as applied stress, pore pressure, and fracture density are coupled to the seismic wave propagation velocity. Therefore, measuring small relative changes of seismic wave velocities in operational mines has the potential for tracking changes in these important rock mass properties. To this end, we have conducted an experiment with the aim of measuring seismic body wave velocities in situ at Williams mine, Hemlo, Canada, using a pneumatic source and multiple receivers. We determine that the signal-to-noise ratio is improved by deconvolving the source signal from the signal recorded at the remotely grouted geophones. We evaluate the estimated relative changes in traveltimes and assume that these are due to changes in the body wave velocity caused by mining-related activities. We are able to successfully detect the source response at remote receivers in an operational mine at a distance of more than 430 m.
A Manifesto in Four Themes
Authors: Segato Rita Laura , McGlazer Ramsey 
Published: August 2019

Abstract
Throughout the Americas, an emphasis on the ideal of the family, defined as the subject of rights to be defended at all costs, has galvanized efforts to demonize and punish what is called “the ideology of gender.” The spokesmen of the historical project of capital thus offer proof, Segato argues, that, far from being residual, minor, or marginal, the question of gender—of the patriarchal order—is the cornerstone and center of gravity of all forms of power.
Manifiesto en cuatro temas
Authors: Segato Rita Laura 
Published: August 2019

Abstract
La presión desatada en todo el continente por demonizar y tornar punible lo que representan como “la ideología de género” y el énfasis en la defensa del ideal de la familia como sujeto de derechos a cualquier costo transforma los voceros del proyecto histórico del capital en fuentes de prueba de que, lejos de ser residual, minoritaria y marginal, la cuestión de género—del orden patriarcal—es la piedra angular y centro de gravedad del edificio de todos los poderes.
Counter-Critical Theory: An Intervention in Contemporary Critical Thought and Practice
Authors: Harcourt Bernard E. 
Published: August 2019

Abstract
Walter Benjamin and Bertolt Brecht's short-lived project for a critical theory journal, Krise und Kritik, foundered in 1931 on the shoals of positivism. Since then, a series of anti-foundational challenges to traditional critical theory has fragmented the landscape of critical theory and, especially, critical praxis, leaving us disarmed today, in these unprecedented times. This essay offers a way forward by means of what it calls “counter-critical theory”: a critical method that indexes the original impulse of critical theory, but liberates it from its foundation in order to allow for a more open-ended and permanent re-examination of how power circulates and recirculates throughout society. Counter-critical theory is a pure theory of illusions and calls for a strategic, ecumenical practice of political disobedience, accompanied by an unrelenting and resolute deployment of interpretation and resignification.
EGFP insertional mutagenesis reveals multiple FXR2P fibrillar states with differing ribosome association in neurons
Authors: Stackpole Emily E. , Akins Michael R. , Ivshina Maria , Murthy Anastasia C. , Fawzi Nicolas L. , Fallon Justin R. 
Published: August 2019

ABSTRACT
RNA-binding proteins (RBPs) function in higher-order assemblages such as RNA granules to regulate RNA localization and translation. The Fragile X homolog FXR2P is an RBP essential for formation of neuronal Fragile X granules that associate with axonal mRNA and ribosomes in the intact brain. However, the FXR2P domains important for assemblage formation in a cellular system are unknown. Here we used an EGFP insertional mutagenesis approach to probe for FXR2P intrinsic features that influence its structural states. We tested 18 different in-frame FXR2PEGFP fusions in neurons and found that the majority did not impact assemblage formation. However, EGFP insertion within a 23 amino acid region of the low complexity (LC) domain induced FXR2PEGFP assembly into two distinct fibril states that were observed in isolation or in highly-ordered bundles. FXR2PEGFP fibrils exhibited different developmental timelines, ultrastructures and ribosome associations. Formation of both fibril types was dependent on an intact RNA-binding domain. These results suggest that restricted regions of the LC domain, together with the RNA-binding domain, may be important for FXR2P structural state organization in neurons.
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans
Authors: Wagner Anita , Hofmeister Olga , Rolland Stephane G. , Maiser Andreas , Aasumets Koit , Schmitt Sabine , Schorpp Kenji , Feuchtinger Annette , Hadian Kamyar , Schneider Sabine , Zischka Hans , Leonhardt Heinrich , Conradt Barbara , Gerhold Joachim M. , Wolf Alexander 
Published: August 2019

ABSTRACT
The Fe(II) and 2-oxoglutarate-dependent oxygenase Alkb homologue 1 (Alkbh1) has been shown to act on a wide range of substrates, like DNA, tRNA and histones. Thereby different enzymatic activities have been identified including, among others, demethylation of N3-methylcytosine (m3C) in RNA- and single-stranded DNA oligonucleotides, demethylation of N1-methyladenosine (m1A) in tRNA or formation of 5-formyl cytosine (f5C) in tRNA. In accordance with the different substrates, Alkbh1 has also been proposed to reside in distinct cellular compartments in human and mouse cells, including the nucleus, cytoplasm and mitochondria. Here, we describe further evidence for a role of human Alkbh1 in regulation of mitochondrial protein biogenesis, including visualizing localization of Alkbh1 into mitochondrial RNA granules with super-resolution 3D SIM microscopy. Electron microscopy and high-resolution respirometry analyses revealed an impact of Alkbh1 level on mitochondrial respiration, but not on mitochondrial structure. Downregulation of Alkbh1 impacts cell growth in HeLa cells and delays development in Caenorhabditis elegans, where the mitochondrial role of Alkbh1 seems to be conserved. Alkbh1 knockdown, but not Alkbh7 knockdown, triggers the mitochondrial unfolded protein response (UPRmt) in C. elegans.
Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro–adipogenic progenitors
Authors: Contreras Osvaldo , Cruz-Soca Meilyn , Theret Marine , Soliman Hesham , Tung Lin Wei , Groppa Elena , Rossi Fabio M. , Brandan Enrique 
Published: August 2019

ABSTRACT
Fibro–adipogenic progenitors (FAPs) are tissue-resident mesenchymal stromal cells (MSCs) required for proper skeletal muscle development, regeneration and maintenance. However, FAPs are also responsible for fibro-fatty scar deposition following chronic damage. We aimed to investigate the role of functional cross-talk between TGF-β and PDGFRα signaling pathways in the fate of FAPs. Here, we show that the number of FAPs correlates with TGF-β levels and with extracellular matrix deposition during regeneration and repair. Interestingly, the expression of PDGFRα changed dynamically in the fibroblast lineage after injury. Furthermore, PDGFRα-dependent immediate early gene expression changed during regeneration and repair. We also found that TGF-β signaling reduces PDGFRα expression in FAPs, mouse dermal fibroblasts and in two related mesenchymal cell lines. Moreover, TGF-β promotes myofibroblast differentiation of FAPs but inhibits their adipogenicity. Accordingly, TGF-β impairs the expression of PDGFRα-dependent immediate early genes in a TGFBR1-dependent manner. Finally, pharmacological inhibition of PDGFRα activity with AG1296 impaired TGF-β-induced extracellular matrix remodeling, Smad2 signaling, myofibroblast differentiation and migration of MSCs. Thus, our work establishes a functional cross-talk between TGF-β and PDGFRα signaling pathways that is involved in regulating the biology of FAPs and/or MSCs.
This article has an associated First Person interview with the first author of the paper.
Strategies for managing paediatric patients in immunoglobulin clinical trials
Authors: Reid Brenda 
Published: August 2019

The continued demand for immunoglobulin treatment for multiple indications has placed considerable strain on the supply of immunoglobulin product. Reliance on a few manufacturers can significantly impact the availability of product. In addition, patient tolerability may vary from one product to another necessitating a choice of products to find the best treatment for an individual patient. Therefore, it is important to conduct clinical trials with new immunoglobulin products to ensure that there is adequate supply and choice of products available on the market. This is particularly important for immunodeficient patients who require treatment with immunoglobulins for life. A requirement for licensing by the Federal Food and Drug Administration and Health Canada is that every immunoglobulin licensing study includes some paediatric patients. Enrolling paediatric subjects in immunoglobulin clinical trials can be challenging due to the need for both consent and assent for enrolment, as well as the increased demands that the study protocol places on the child and family over their usual clinical care. Therefore, it is necessary to utilize strategies that make the demands of the protocol more tolerable for children, and to ensure that the study documentation reflects the unique needs of paediatric patients (Denhoff et al. 2015). Statement of novelty: This paper discusses strategies to facilitate enrolment and adherence to immunoglobulin study protocols that are unique to paediatric patients.
Parental attitude toward children’s mental disorders and its relationship with help seeking behaviors
Authors: Ebrahimi Hossein , Movaghari Mohammad Reza , Bazghaleh Milad , Shirmohammadi Nasim , Mohammadpourhodki Reza 
Published: August 2019

Abstract

Background
The purpose of the study was to assess parent’s attitudes toward mental illness in children and its relationship with help seeking behaviors.

Method
This cross-sectional study was conducted in a pediatric psychiatric clinic of under affiliation of Tehran University of Medical Sciences in 2016–2017. All children’s parents or guardians who referred for the first time to the clinics were the study population. Convenient sampling was applied and 400 subjects were included by survey method. The data collection tool for this study included a form for demographic data, a questionnaire for assessing parents’ attitude toward the causes, behavioral demonstrations and treatment of mental disorders in children, and finally a checklist to determine help seeking behaviors. Descriptive and inferential statistics was applied with SPSS software version 16 for data analysis.

Results
Of the parents, 93.7% had a good attitude toward mental illness in the three studied realms. Of the parents, 56.25% referred to official sources of help. The results of this research showed that there was a significant difference between the mean scores of parents’ attitude (sum of the three areas) in terms of child’s gender, parents’ marital status, father’s job, father’s education, and mother’s education and there was a significant relationship between help seeking behavior of parents just with fathers’ education level (p<0.05).

Conclusions
The results showed that parents had a good attitude toward their children’s mental disorders. However, it should not be overlooked that nearly half of the parents were still referring to unofficial sources of assistance.
A 4D Trajectory Prediction Model Based on the BP Neural Network
Authors: Wu Zhi-Jun , Tian Shan , Ma Lan 
Published: August 2019

Abstract
To solve the problem that traditional trajectory prediction methods cannot meet the requirements of high-precision, multi-dimensional and real-time prediction, a 4D trajectory prediction model based on the backpropagation (BP) neural network was studied. First, the hierarchical clustering algorithm and the k-means clustering algorithm were adopted to analyze the total flight time. Then, cubic spline interpolation was used to interpolate the flight position to extract the main trajectory feature. The 4D trajectory prediction model was based on the BP neural network. It was trained by Automatic Dependent Surveillance – Broadcast trajectory from Qingdao to Beijing and used to predict the flight trajectory at future moments. In this paper, the model is evaluated by the common measurement index such as maximum absolute error, mean absolute error and root mean square error. It also gives an analysis and comparison of the predicted over-point time, the predicted over-point altitude, the actual over-point time and the actual over-point altitude. The results indicate that the predicted 4D trajectory is close to the real flight data, and the time error at the crossing point is no more than 1 min and the altitude error at the crossing point is no more than 50 m, which is of high accuracy.
Evaluation of terrestrial and airborne gravity data over Antarctica – a generic approach
Authors: Zingerle P. , Pail R. , Scheinert M. , Schaller T. 
Published: August 2019

Abstract
The AntGrav project, funded by the German Research Foundation (DFG) has the main objective to homogenize and optimize Antarctic gravity field information. Within this project an evaluation procedure is needed to inspect all different kind of gravity field surveys available in Antarctica. In this paper a suitable methodology is proposed.
We present an approach for fast 3D gravity point data reduction in different spectral bands. This is achieved through pre-calculating a fine 3D mesh of synthesized gravity functionals over the entirety of the Antarctic continent, for which two different global models are used: the combined satellite model GOCO05s for the long-wavelength part, and the topographic model Earth2014 for the shorter wavelengths. To maximize the applicability separate meshes are calculated for different spectral bands in order to specifically reduce a certain band or a selected combination. All meshes are calculated for gravity anomalies as well as gravity disturbances. Utilizing these meshes, synthesized gravity data at arbitrary positions is computed by conventional 3D interpolation methods (e.g. linear, cubic or spline).
It is shown that the applied approach can reach a worst-case interpolation error of less than 1 mGal. Evaluation results are presented for the AntGG grid and exemplary for the in-situ measurements of the AGAP and BAS-LAND campaigns. While general properties, large-scale errors and systematic effects can usually be detected, small-scale errors (e.g. of single points) are mostly untraceable due to the uncertainties within the topographic model.
Investing in the future: Korean early English education as neoliberal management of youth
Authors: Bae Sohee , Park Joseph Sung-Yul 
Published: August 2019

Abstract
This paper examines how entrepreneurial visions of the future contribute to neoliberalism’s appropriation of language learning as a strategy for capital accumulation. Taking as an example South Korea’s heavy investment in children’s English language learning – commonly known as early English education (yeongeo jogi gyoyuk) – it discusses how affective conditions of anticipation (Adams, Murphy and Clarke. 2009. Anticipation: Technoscience, life, affect, temporality. Subjectivity 28(1). 246–265.) may serve as a basis for rationalizing the incorporation of language learning as an essential element of entrepreneurial visions of the self. Based on examples from the discourse of the Korean private English education market and ethnographic observations from early study abroad (jogi yuhak) families in Singapore, we show how the English language learning of young children in the Korean context was framed and justified as an investment in the future. We then discuss how parents’ hopes and fears about their children’s future played a major role in transforming English language learning into a matter of neoliberal anticipation. We conclude by considering how this affective orientation to the future inherent in early English education may serve as a juncture for critiquing the entrepreneurial vision of the self that underlies the logic of human capital development.