bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of Technical Parameters for MR of the Small Bowel in non-IBD Conditions over the Last Ten Years
Authors: Lu Jingyu , Zhou Ziling , Morelli John N. , Yu Hao , Luo Yan , Hu Xuemei , Li Zhen , Hu Daoyu , Shen Yaqi 
Published: October 2019

AbstractTechnical guidelines for magnetic resonance imaging (MRI) of the small bowel (SB) in the setting of inflammatory bowel diseases (IBDs) were detailed in a 2017 consensus issued by European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Pediatric Radiology (ESPR); however, MRI for non-IBD conditions was not addressed. Hence, we performed a systematic review collecting researches on SB MRI for non-IBDs. The literatures were then divided into morphologic group and functional group. Information about the MRI techniques, gastrointestinal preparation, and details of cine-MRI protocols was extracted. We found that a 1.5 T MRI system, prone positioning, and MR enterography were frequently utilized in clinical practice. Gadolinium contrast sequences were routinely implemented, while diffusion-weighted imaging (DWI) was much less performed. The gastrointestinal preparation varied throughout the studies. No uniform protocols for cine imaging could be established. SB MRI examinations for non-IBDs are far from standardized, especially for functional studies. Recommendations for standard parameters in cine-MRI sequences are difficult to make due to lack of evidentiary support. MRI investigations in non-IBD conditions are needed and the standardization of non-IBD imaging in clinical practice is required.
Split application of reduced nitrogen rate improves nitrogen uptake and use efficiency in sweetpotato
Authors: Du Xiangbei , Xi Min , Kong Lingcong 
Published: October 2019

AbstractSplitting nitrogen (N) application is beneficial for enhancing sweetpotato growth and promoting optimum yields under reduced N rates; however, studies concerning how split N can affect sweetpotato N dynamics and utilization are limited. Field experiments were conducted from 2015 to 2016 to determine how split N application affects sweetpotato N uptake and N use efficiency (NUE) under a reduced N rate. Two cultivars (Xushu 22 and Shangshu 19) were planted under four N treatments, a conventional basal application of 100 kg N ha−1 (100:0), a basal application of 80 kg N ha−1 (80:0), two equal split applications of 80 kg N ha−1 (basal and 35 days after transplanting, 40:40) and a N omission treatment (N0). Data from two years revealed that sweetpotato yields decreased at a reduced 20% N rate with a basal application (80:0); however, the reduced 20% N rate with a split application (40:40) significantly increased the yield by 16.6–19.0%. Although the 80:0 treatment decreased sweetpotato N uptake, the 40:40 treatment increased the N uptake by increasing the N uptake rate and prolonging the duration of the fast N uptake phase. In comparison to the basal application, the split N application used N more efficiently, showing consistently higher levels of agronomic use efficiency, recovery efficiency, physiological efficiency and partial factor productivity. NUEs under split N improved due to increased N uptake during the middle and late growth stages and a higher N partition ratio to the storage root. The above results indicate that split N application provides better N for crop developmental stages and is recommended as an alternative approach to simultaneously increasing storage root yield and NUE under a reduced N rate in sweetpotato production in China.
The spread of presaccadic attention depends on the spatial configuration of the visual scene
Authors: Szinte Martin , Puntiroli Michael , Deubel Heiner 
Published: October 2019

AbstractWhen preparing a saccade, attentional resources are focused at the saccade target and its immediate vicinity. Here we show that this does not hold true when saccades are prepared toward a recently extinguished target. We obtained detailed maps of orientation sensitivity when participants prepared a saccade toward a target that either remained on the screen or disappeared before the eyes moved. We found that attention was mainly focused on the immediate surround of the visible target and spread to more peripheral locations as a function of the distance from the cue and the delay between the target’s disappearance and the saccade. Interestingly, this spread was not accompanied with a spread of the saccade endpoint. These results suggest that presaccadic attention and saccade programming are two distinct processes that can be dissociated as a function of their interaction with the spatial configuration of the visual scene.
CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression
Authors: Cano-Crespo Sara , Chillarón Josep , Junza Alexandra , Fernández-Miranda Gonzalo , García Judit , Polte Christine , R. de la Ballina Laura , Ignatova Zoya , Yanes Óscar , Zorzano Antonio , Stephan-Otto Attolini Camille , Palacín Manuel 
Published: October 2019

AbstractCD98 heavy chain (CD98hc) forms heteromeric amino acid (AA) transporters by interacting with different light chains. Cancer cells overexpress CD98hc-transporters in order to meet their increased nutritional and antioxidant demands, since they provide branched-chain AA (BCAA) and aromatic AA (AAA) availability while protecting cells from oxidative stress. Here we show that BCAA and AAA shortage phenocopies the inhibition of mTORC1 signalling, protein synthesis and cell proliferation caused by CD98hc ablation. Furthermore, our data indicate that CD98hc sustains glucose uptake and glycolysis, and, as a consequence, the pentose phosphate pathway (PPP). Thus, loss of CD98hc triggers a dramatic reduction in the nucleotide pool, which leads to replicative stress in these cells, as evidenced by the enhanced DNA Damage Response (DDR), S-phase delay and diminished rate of mitosis, all recovered by nucleoside supplementation. In addition, proper BCAA and AAA availability sustains the expression of the enzyme ribonucleotide reductase. In this regard, BCAA and AAA shortage results in decreased content of deoxynucleotides that triggers replicative stress, also recovered by nucleoside supplementation. On the basis of our findings, we conclude that CD98hc plays a central role in AA and glucose cellular nutrition, redox homeostasis and nucleotide availability, all key for cell proliferation.
Association between menstrual cycle irregularity and tinnitus: a nationwide population-based study
Authors: Yu Jin-Na , Nam Ga Eun , Han Kyungdo , Kim Ji-su , Kim Yang-Hyun , Cho Kyung Hwan , Kang Gunseog , Roh Yong Kyun 
Published: October 2019

AbstractThis population-based cross-sectional study investigated the association between menstrual cycle irregularity and tinnitus in premenopausal Korean women. We used data from the 5th Korea National Health and Nutrition Examination Survey (2010–2012). A total of 4633 premenopausal women were included. Hierarchical multivariable logistic regression analysis was performed. Individuals with tinnitus accounted for 21.6%. Women with tinnitus or menstrual irregularity had significantly higher rates of stress, depressive mood, and suicidal ideation than those without. The proportion of individuals with irregular menstrual cycles with duration of longer than 3 months increased as the severity of tinnitus increased (P = 0.01). After adjusting for confounding variables, the odds of tinnitus increased in individuals with irregular menstrual cycles compared to those with regular menstrual cycles. The odds ratios (ORs) of tinnitus tended to increase as the duration of menstrual irregularity became longer (1.37, 95% confidence interval: 1.06–1.78 for duration of up to 3 months; 1.71, 1.03–2.85 for duration of longer than 3 months, P for trend = 0.002). Our study found a positive association between menstrual cycle irregularity and tinnitus. Menstrual cycle irregularity may be a related factor of tinnitus in women with childbearing age.
Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction
Authors: Bassett Shalome A. , Young Wayne , Fraser Karl , Dalziel Julie E. , Webster Jim , Ryan Leigh , Fitzgerald Patrick , Stanton Catherine , Dinan Timothy G. , Cryan John F. , Clarke Gerard , Hyland Niall , Roy Nicole C. 
Published: October 2019

AbstractStress negatively impacts gut and brain health. Individual differences in response to stress have been linked to genetic and environmental factors and more recently, a role for the gut microbiota in the regulation of stress-related changes has been demonstrated. However, the mechanisms by which these factors influence each other are poorly understood, and there are currently no established robust biomarkers of stress susceptibility. To determine the metabolic and microbial signatures underpinning physiological stress responses, we compared stress-sensitive Wistar Kyoto (WKY) rats to the normo-anxious Sprague Dawley (SD) strain. Here we report that acute stress-induced strain-specific changes in brain lipid metabolites were a prominent feature in WKY rats. The relative abundance of Lactococcus correlated with the relative proportions of many brain lipids. In contrast, plasma lipids were significantly elevated in response to stress in SD rats, but not in WKY rats. Supporting these findings, we found that the greatest difference between the SD and WKY microbiomes were the predicted relative abundance of microbial genes involved in lipid and energy metabolism. Our results provide potential insights for developing novel biomarkers of stress vulnerability, some of which appear genotype specific.
Post-transplant laronidase augmentation for children with Hurler syndrome: biochemical outcomes
Authors: Lund Troy C. , Miller Weston P. , Liao Ai Yin , Tolar Jakub , Shanley Ryan , Pasquali Marzia , Sando Nicole , Bigger Brian W. , Polgreen Lynda E. , Orchard Paul J. 
Published: October 2019

AbstractAllogeneic hematopoietic cell transplantation (HCT) benefits children with Hurler syndrome (MPS-IH). However, survivors remain burdened by substantial MPS-IH related residual disease. We studied the feasibility, safety and biochemical impact of augmentative recombinant intravenous enzyme replacement therapy (IV-ERT) post transplantation. Ten children with MPS-IH and ≥2 years from successful HCT underwent IV-ERT for 2 years’ duration. Patients were monitored for anti-drug antibody (ADA) development, including inhibitory capacity and changes in urinary excretion of glycosaminoglycans (uGAG). Three patients demonstrated low-level ADA at baseline, though all children tolerated IV-ERT well. Eight patients developed ADA over the 2-year study, with 3 (38%) meeting criteria for an inhibitory ADA response. The aggregate cohort experienced a reduction in uGAG from baseline to study end, which was enhanced in children with low or no ADA response. Conversely, children with inhibitory ADA showed increase in uGAG over time. IV-ERT in previously transplanted children with MPS-IH appears safe and can reduce uGAG, although this is reversed by the presence of inhibitory ADA. These data show a biochemical change after initiation of post-HCT IV-ERT, but the occurrence of ADA and inhibitory antibodies are a concern and should be monitored in future efficacy trials. This trial was registered at www.clinicaltrials.gov, NCT01173016, 07/30/2010.
Neurophenomenology of near-death experience memory in hypnotic recall: a within-subject EEG study
Authors: Martial Charlotte , Mensen Armand , Charland-Verville Vanessa , Vanhaudenhuyse Audrey , Rentmeister Daniel , Bahri Mohamed Ali , Cassol Héléna , Englebert Jérôme , Gosseries Olivia , Laureys Steven , Faymonville Marie-Elisabeth 
Published: October 2019

AbstractThe neurobiological basis of near-death experiences (NDEs) is unknown, but a few studies attempted to investigate it by reproducing in laboratory settings phenomenological experiences that seem to closely resemble NDEs. So far, no study has induced NDE-like features via hypnotic modulation while simultaneously measuring changes in brain activity using high-density EEG. Five volunteers who previously had experienced a pleasant NDE were invited to re-experience the NDE memory and another pleasant autobiographical memory (dating to the same time period), in normal consciousness and with hypnosis. We compared the hypnosis-induced subjective experience with the one of the genuine experience memory. Continuous high-density EEG was recorded throughout. At a phenomenological level, we succeeded in recreating NDE-like features without any adverse effects. Absorption and dissociation levels were reported as higher during all hypnosis conditions as compared to normal consciousness conditions, suggesting that our hypnosis-based protocol increased the felt subjective experience in the recall of both memories. The recall of a NDE phenomenology was related to an increase of alpha activity in frontal and posterior regions. This study provides a proof-of-concept methodology for studying the phenomenon, enabling to prospectively explore the NDE-like features and associated EEG changes in controlled settings.
Next-Generation Sequencing reveals relationship between the larval microbiome and food substrate in the polyphagous Queensland fruit fly
Authors: Majumder Rajib , Sutcliffe Brodie , Taylor Phillip W. , Chapman Toni A. 
Published: October 2019

AbstractInsects typically host substantial microbial communities (the ‘microbiome’) that can serve as a vital source of nutrients and also acts as a modulator of immune function. While recent studies have shown that diet is an important influence on the gut microbiome, very little is known about the dynamics underpinning microbial acquisition from natural food sources. Here, we addressed this gap by comparing the microbiome of larvae of the polyphagous fruit fly Bactrocera tryoni (‘Queensland fruit fly’) that were collected from five different fruit types (sapodilla [from two different localities], hog plum, pomegranate, green apple, and quince) from North-east to South-east Australia. Using Next-Generation Sequencing on the Illumina MiSeq platform, we addressed two questions: (1) what bacterial communities are available to B. tryoni larvae from different host fruit; and (2) how does the microbiome vary between B. tryoni larvae and its host fruit? The abundant bacterial taxa were similar for B. tryoni larvae from different fruit despite significant differences in the overall microbial community compositions. Our study suggests that the bacterial community structure of B. tryoni larvae is related less to the host fruit (diet) microbiome and more to vertical transfer of the microbiome during egg laying. Our findings also suggest that geographic location may play a quite limited role in structuring of larval microbiomes. This is the first study to use Next-Generation Sequencing to analyze the microbiome of B. tryoni larvae together with the host fruit, an approach that has enabled greatly increased resolution of relationships between the insect’s microbiome and that of the surrounding host tissues.
Capsid amino acids at positions 247 and 270 are involved in the virulence of betanodaviruses to European sea bass
Authors: Moreno Patricia , Souto Sandra , Leiva-Rebollo Rocio , Borrego Juan J. , Bandín Isabel , Alonso M. Carmen 
Published: October 2019

AbstractEuropean sea bass (Dicentrarchus labrax) is severely affected by nervous necrosis disease, caused by nervous necrosis virus (NNV). Two out of the four genotypes of this virus (red-spotted grouper nervous necrosis virus, RGNNV; and striped jack nervous necrosis virus, SJNNV) have been detected in sea bass, although showing different levels of virulence to this fish species. Thus, sea bass is highly susceptible to RGNNV, whereas outbreaks caused by SJNNV have not been reported in this fish species. The role of the capsid protein (Cp) amino acids 247 and 270 in the virulence of a RGNNV isolate to sea bass has been evaluated by the generation of recombinant RGNNV viruses harbouring SJNNV-type amino acids in the above mentioned positions (Mut247Dl965, Mut270Dl965 and Mut247 + 270Dl965). Viral in vitro and in vivo replication, virus virulence and fish immune response triggered by these viruses have been analysed. Mutated viruses replicated on E-11 cells, although showing some differences compared to the wild type virus, suggesting that the mutations can affect the viral cell recognition and entry. In vivo, fish mortality caused by mutated viruses was 75% lower, and viral replication in sea bass brain was altered compared to non-mutated virus. Regarding sea bass immune response, mutated viruses triggered a lower induction of IFN I system and inflammatory response-related genes. Furthermore, mutations caused changes in viral serological properties (especially the mutation in amino acid 270), inducing higher seroconversion and changing antigen recognition.
The effect of chronic cerebral hypoperfusion on the pathology of Alzheimer's disease: A positron emission tomography study in rats
Authors: Park Jae-Hyung , Hong Jeong-Ho , Lee Sang-Woo , Ji Hyun Dong , Jung Jung-Ah , Yoon Kyung-Wha , Lee Jung-In , Won Kyoung Sook , Song Bong-Il , Kim Hae Won 
Published: October 2019

AbstractCerebrovascular disease is a potential risk factor for Alzheimer's disease (AD). Although acute cerebral hypoperfusion causes neuronal necrosis and infarction, chronic cerebral hypoperfusion induces apoptosis in neurons, but its effects on the cognitive impairment are not clear. The purpose of this study was to evaluate the effects of chronic cerebral hypoperfusion on AD pathology and cerebral glucose metabolism. A model of chronic cerebral hypoperfusion was established by ligating the common carotid arteries bilaterally in adult male rats (CAL group). Sham-operated rats underwent the same procedures without artery ligation (control group). At 12 weeks after ligation, expression levels of amyloid-β (Aβ) and hyperphosphorylated tau (p-tau), as well as the regional cerebral glucose metabolism, were evaluated using Western blots and positron emission tomography with fluorine-18 fluorodeoxyglucose, respectively. The expression levels of Aβ in the frontal cortex and hippocampus and of p-tau in the temporal cortex were significantly higher in the CAL group than those in the control group. The cerebral glucose metabolism of the amygdala, entorhinal cortex, and hippocampus was significantly decreased in the CAL group compared to that in the control. These results suggest that chronic cerebral hypoperfusion can induce AD pathology and may play a significant role in AD development.
The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment
Authors: Kumrungsee Thanutchaporn , Kariya Taishi , Hashimoto Kotaro , Koyano Takayuki , Yazawa Nao , Hashimoto Takao , Sanada Yohei , Matsuyama Makoto , Sotomaru Yusuke , Sakurai Hiroaki , van de Loo Fons A. J. , Yanaka Noriyuki 
Published: October 2019

AbstractTubulointerstitial fibrosis is a progressive process affecting the kidneys, causing renal failure that can be life-threatening. Thus, renal fibrosis has become a serious concern in the ageing population; however, fibrotic development cannot be diagnosed early and assessed noninvasively in both patients and experimental animal models. Here, we found that serum amyloid A3 (Saa3) expression is a potent indicator of early renal fibrosis; we also establishedin vivoSaa3/C/EBPβ-promoter bioluminescence imaging as a sensitive and specific tool for early detection and visualization of tubulointerstitial fibrosis. Saa3 promoter activity is specifically upregulated in parallel with tumor necrosis factor α (TNF-α) and fibrotic marker collagen I in injured kidneys. C/EBPβ, upregulated in injured kidneys and expressed in tubular epithelial cells, is essential for the increased Saa3 promoter activity in response to TNF-α, suggesting that C/EBPβ plays a crucial role in renal fibrosis development. Our model successfully enabled visualization of the suppressive effects of a citrus flavonoid derivative, glucosyl-hesperidin, on inflammation and fibrosis in kidney disease, indicating that this model could be widely used in exploring therapeutic agents for fibrotic diseases.
New Type of Spectral Nonlinear Resonance Enhances Identification of Weak Signals
Authors: Lin Rongming , Ng Teng Yong , Fan Zheng 
Published: October 2019

AbstractSome nonlinear systems possess innate capabilities of enhancing weak signal transmissions through a unique process called Stochastic Resonance (SR). However, existing SR mechanism suffers limited signal enhancement from inappropriate entraining signals. Here we propose a new and effective implementation, resulting in a new type of spectral resonance similar to SR but capable of achieving orders of magnitude higher signal enhancement than previously reported. By employing entraining frequency in the range of the weak signal, strong spectral resonances can be induced to facilitate nonlinear modulations and intermodulations, thereby strengthening the weak signal. The underlying physical mechanism governing the behavior of spectral resonances is examined, revealing the inherent advantages of the proposed spectral resonances over the existing implementation of SR. Wide range of parameters have been found for the optimal enhancement of any given weak signal and an analytical method is established to estimate these required parameters. A reliable algorithm is also developed for the identifications of weak signals using signal processing techniques. The present work can significantly improve existing SR performances and can have profound practical applications where SR is currently employed for its inherent technological advantages.
Solar survey at Pic du Midi: Calibrated data and improved images
Authors: Koechlin Laurent , Dettwiller Luc , Audejean Maurice , Valais Maël , López Ariste Arturo 
Published: October 2019

Context. We carry out a solar survey with images of the photosphere, prominences, and corona at Pic du Midi observatory. This survey, named CLIMSO (for CLIchés Multiples du SOleil), is in the following spectral lines: Fe XIII corona (1.075 μm), Hα (656.3 nm), and He I (1.083 μm) prominences, and Hα and Ca II (393.4 nm) photosphere. All frames cover 1.3 times the diameter of the Sun with an angular resolution approaching one arcsecond. The frame rate is one per minute per channel (weather permitting) for the prominences and chromosphere, and one per hour for the Fe XIII corona. This survey started in 2007 for the disk and prominences and in 2015 for the corona. We have almost completed one solar cycle and hope to cover several more, keeping the same wavelengths or adding others.
Aims. We seek to make the CLIMSO images easier to use and more profitable for the scientific community.
Methods. At the beginning of the survey, the images that we sent to the CLIMSO database were not calibrated. We have implemented a photometric calibration for the present and future images, in order to provide “science-ready” data. The old images have been calibrated. We have also improved the contrast capabilities of our coronagraphs, which now provide images of the Fe XIII corona, in addition to previous spectral channels. We also implemented an autoguiding system based on a diffractive Fresnel array for precise positioning of the Sun behind coronagraphic masks.
Results. The data, including the images and films, are publicly available and downloadable through virtual observatories and dedicated websites (use “CLIMSO” and “IRAP” keywords to find them). For the Hα and Ca II channels we calibrate the data into physical units, independent of atmospheric or instrumental conditions; we provide solar maps of spectral radiances in W m−2 sr−1 nm−1. The instrumental improvements and calibration process are presented in this paper.