bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Xenobiotic Receptors on Hepatic Glycolipid Metabolism
Authors: Chen Ke , Zhong Jinwei , Hu Lin , Li Ruliu , Du Qun , Cai Jiazhong , Li Yanwu , Gao Yong , Cui Xiaona , Yang Xiaoying , Wu Xiaojie , Yao Lu , Dai Juji , Wang Yan , Jin Haiyong 
Published: September 2018

Background:
PXR (Pregnane X Receptor) and CAR (Constitutive Androstane Receptor) are termed as
xenobiotic receptors, which are known as core factors in regulation of the transcription of metabolic enzymes and
drug transporters. However, accumulating evidence has shown that PXR and CAR exert their effects on energy metabolism
through the regulation of gluconeogenesis, lipogenesis and β-oxidation. Therefore, in this review, we are
trying to summary recent advances to show how xenobiotic receptors regulate energy metabolism.

Methods:
A structured search of databases has been performed by using focused review topics. According to conceptual
framework, the main idea of research literature was summarized and presented.

Results:
For introduction of each receptor, the general introduction and the critical functions in hepatic glucose and
lipid metabolism have been included. Recent important studies have shown that CAR acts as a negative regulator of
lipogenesis, gluconeogenesis and β -oxidation. PXR activation induces lipogenesis, inhibits gluconeogenesis and
inhabits β-oxidation.

Conclusion:
In this review, the importance of xenobiotic receptors in hepatic glucose and lipid metabolism has been
confirmed. Therefore, PXR and CAR may become new therapeutic targets for metabolic syndrome, including obesity
and diabetes. However, further research is required to promote the clinical application of this new energy metabolism
function of xenobiotic receptors.
Dietary Patterns: A New Therapeutic Approach for Depression?
Authors: Jesus Mariana , Silva Tânia , Cagigal César , Martins Vera , Silva Carla 
Published: September 2018

Introduction:
The field of nutritional psychiatry is a fast-growing one. Although initially, it
focused on the effects of vitamins and micronutrients in mental health, in the last decade, its focus also
extended to the dietary patterns. The possibility of a dietary cost-effective intervention in the most
common mental disorder, depression, cannot be overlooked due to its potential large-scale impact.

Method:
A classic review of the literature was conducted, and studies published between 2010 and
2018 focusing on the impact of dietary patterns in depression and depressive symptoms were included.

Results:
We found 10 studies that matched our criteria. Most studies showed an inverse association between
healthy dietary patterns, rich in fruits, vegetables, lean meats, nuts and whole grains, and with
low intake of processed and sugary foods, and depression and depressive symptoms throughout an array
of age groups, although some authors reported statistical significance only in women. While most
studies were of cross-sectional design, making it difficult to infer causality, a randomized controlled
trial presented similar results.

Discussion:
he association between dietary patterns and depression is now well-established, although
the exact etiological pathways are still unknown. Dietary intervention, with the implementation of
healthier dietary patterns, closer to the traditional ones, can play an important role in the prevention
and adjunctive therapy of depression and depressive symptoms.

Conclusion:
More large-scale randomized clinical trials need to be conducted, in order to confirm the
association between high-quality dietary patterns and lower risk of depression and depressive symptoms.
The Assessment of Anxiety and Depression and its Associated Factors in SLE
Authors: Kwan Andrew , Katz Patricia , Touma Zahi 
Published: September 2018

Background:
Depression and anxiety are common neuropsychiatric complaints in patients
with Systemic Lupus Erythematosus (SLE). While numerous studies have been performed to
investigate the prevalence, impact, and associated factors of depression and anxiety, current literature
presents mixed results. In particular, the prevalence of anxiety and depression varies substantially
between studies due to methodological limitations, and heterogeneity in defining anxiety and
depression, patient selection, and metrics used. Moreover, there is a lack of studies evaluating the
validity, reliability, and interpretability of commonly used screening tools for depression and anxiety
in SLE patients.

Result and Conclusion:
Further investigations should aim to reach a consensus surrounding the
role of controversial associated factors in depression and anxiety of SLE patients, while also focusing
on the identification of novel factors that have not yet been highlighted in the literature.
El impacto de las nuevas tecnologías en el empleo en México
Authors: Minian Isaac , Martinez Monroy Ángel 
Published: September 2018

<p>En el presente estudio se evalúa la vulnerabilidad del empleo ante el avance de las nuevas tecnologías. Con la metodología de Frey y Osborne (2013), se estima que<br />63% del empleo total y 64.5% del empleo manufacturero en México está en riesgo<br />de ser automatizado, ocasionando que sean los trabajadores menos calificados los más vulnerables. Para ello se estimó exclusivamente la factibilidad técnica de automatización; el empleo que realmente sería desplazado requeriría analizar factores económicos, políticos y sociales. Históricamente, la principal consecuencia de la automatización han sido los cambios significativos en la estructura laboral y no el desempleo masivo. Los mecanismos de mercado y las políticas públicas han compensado los impactos de los <em>shocks</em> tecnológicos. De tal manera que aunque el cambio tecnológico desplaza trabajadores, también genera nuevos empleos al crear oportunidades de inversión.</p>
FORMULATION DEVELOPMENT AND EVALUATION OF TRANSFEROSOMAL GEL
Authors: Thakur Neha , Jain Prabhat , Jain Vivek 
Published: September 2018

Transfersomes are particularly optimized, ultradeformable (ultraflexible) lipid supramolecular aggregates, which are able to penetrate the mammalian skin intact. Transfersome is a type of carrier system which is capable of transdermal delivery of low as well as high molecular weight drugs. Transfersomes penetrate through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form. Acne vulgaris is a disease of the pilosebaceous follicle characterized by non-inflammatory (open and closed comedones) and inflammatory lesions (papules, pustules, and nodules). In such situation transdermal drug delivery remains the most preferential mode of administration. But, stratum corneum forms the most formidable barrier for the penetration of drug through skin. To overcome the stratum corneum barrier, the use of lipid vesicles like transfersomes in delivery systems has involved increasing attention in recent years. The aim of the present study was to statistically optimize the vesicular formulations (Transfersomes) for enhanced skin delivery of a model drug Clindamycin Phosphate.
Keywords: Transfersomes, Acne vulgaris, Clindamycin Phosphate
Citrus limon L Burmf peel: Potential anthelmintic agent against Indian Earthworm Eicinia foetida
Authors: Upadhyaya Sristisri 
Published: September 2018

Helminthiasis or worm infection is a common infection in human, affecting a large population of the world. Considering this, anthelmintic activity of citrus limon peel was carried out in this experiment. Citrus limon belongs to family Rutaceae. Ethyl acetate, ethanol and methanol extracts of citrus limonn peel have been evaluated for anthelmintic activity against Indian Earthworm species Eicinia foetida.The results reveal a dose dependent increase in activity of the extracts at 5, 10 and 20 mg/ml concentrations. All the extracts exhibited better activity then standard compound Albendazole. Ethanol extract exhibited highest activity among the extract.
Keyword: Anthelmintic activity; Eicinia Foetida, Albendazole.
Antibacterial, antifungal and antioxidant activity of Dichapetalum gelonioides (Roxb.) Engl. (Dichapetalaceae)
Authors: Priyanka GS , Bharadwaj Nitish A , Sachin MB , Prashith Kekuda TR 
Published: September 2018

Objectives: Dichapetalum gelonioides (Roxb.) Engl. belongs to the family Dichapetalaceae. In the present study, we investigated antibacterial, antifungal and antioxidant activity of methanolic extract of leaf and fruit of D. gelonioides.
Methods: Maceration process was carried out for extraction of leaf and fruit of D. gelonioides. Agar well diffusion method was employed to evaluate antibacterial activity of extracts against gram positive and gram negative bacteria. Poisoned food technique was performed to investigate antifungal activity of extracts against two seed-borne fungi. Antioxidant activity was evaluated by DPPH radical scavenging and ferric reducing assays.
Results: Both leaf and fruit extracts were effective in causing inhibition of all test bacteria. Highest and least inhibitory activity was observed against Bacillus cereus and Escherichia coli respectively. Both Aspergillus niger and Bipolaris sp. were inhibited to >50% by leaf and fruit extracts. Extent of inhibition of Bipolaris sp. was slightly higher when compared to A. niger. Both leaf and fruit extracts showed a dose dependent scavenging of DPPH radicals with high activity being showed by leaf extract. Leaf extract was shown to exhibit marked reducing potential than fruit extract.
Conclusions: Overall, leaf extract was shown to be more effective in displaying antioxidant activity and causing inhibition of bacteria and fungi when compared to fruit extract. The results indicate that the plant possess active principles which are to be purified, characterized and subjected for antimicrobial and antioxidant assays in further studies.
Keywords: Dichapetalum gelonioides, Maceration, Agar well diffusion, Poisoned food technique, DPPH, Ferric reducing
Antioxidant and antifungal activity of Geophila repens (L.) I. M. Johnst. (Rubiaceae)
Authors: Sahana BK , Akhilesha Shahneel , Priyanka GS , Prashith Kekuda TR 
Published: September 2018

Objectives: The present study was conducted to investigate the potential of leaf extract of Geophila repens (L.) I.M. Johnst. (Rubiaceae) to exhibit antioxidant and antifungal potential.
Methods: Extraction of powdered leaf material was carried out by maceration process using methanol. Antioxidant activity of leaf extract was assessed by DPPH free radical scavenging assay and ferric reducing assay. Antifungal activity of leaf extract was determined by Poisoned food technique.
Results: Leaf extract was shown to scavenge DPPH radicals dose dependently with IC50 value of 51.39µg/ml. An increase in the absorbance on increasing concentration of leaf extract indicated ferric reducing activity. The extract showed more or less similar inhibitory activity against Aspergillus niger and Bipolaris sp. (>50% inhibition).
Conclusion: The results of the study indicate that leaf extract possesses bioactive principles with activity against oxidative damage and seed-borne fungi which are to be purified and screened for antioxidant and antifungal activity.
Keywords: Geophila repens, Maceration, DPPH, Ferric reducing, Seed-borne fungi, Poisoned food technique
EVALUATION OF ANTIDIABETIC ACTIVITY OF LEUCOMERIS SPECTABILIS EXTRACT IN ALLOXAN-INDUCED DIABETIC RATS
Authors: Baiga Ved Pal , Kumar Kuldeep , Yadav Shivansh , Kumar Prevesh , Shukla Divakar , Mani Munesh 
Published: September 2018

The objective of the study is to investigate the hydro alcoholic leaves extract of Leucomeris spectabilis (Asteraceae) for hypoglycemic effects in normal and diabetic rats. Acute oral toxicity study indicated that HAE was safe up to a dose of 2000 mg/kg body weight of rats and screened for antidiabetic activity in alloxan (120 mg/ kg, i.p.) induced diabetic rats for 21 days along with phytochemical analyses of HAE were also carried out. In-vivo evaluation of the extracts decreased blood sugar levels with significant improvement in blood glucose level, serum marker enzymes (SGPT, SGOT and ALP) and the content at the end of 1, 2 and 3rd weeks after HAELC treatment. The results suggest of antidiabetic activity study revealed that HAE possesses significant (p < 0.05) hypoglycemic activity compared to diabetic rats group. The results showed that the hydroalcoholic leaves extract has significantly most of effect in 200mg/kg.
Keywords: Leucomeris spectabilis, Leaves, Acute oral toxicity, Alloxan, Ant-diabetic activity.
FORMULATION AND CHARACTERIZATION OF MICROSPHERES OF NITAZOXANIDE BY CHEMICAL CROSSLINKING METHOD
Authors: Sachan A K , Gupta A , Kumari K , Ansari A 
Published: September 2018

The work investigated the design and evaluation of microspheres of Nitazoxanide by Ionotropic gelation technique met. 32 Factorial designs were used and concentration of polymer carbopol-934 (X1) and Ethyl cellulose (X2) were selected as the independent variables. The surface morphology study by SEM indicated that microspheres were spherical with smooth surface. There was no interaction between the drug and polymers, as studied by FTIR study. The prepared microspheres were characterized by entrapment efficiency, particle size micromeritic properties. It was observed that on increasing polymer concentration of formulations, % yield, the entrapment efficiency and particle size were increased whereas % drug release decreased. The In Vitro release study was done using U.S.P. dissolution rate basket type apparatus in phosphate buffer pH 7.4 for 10 hr. It shows that on increasing polymer concentration the drug release of all formulations was gradually decreased. In Vitro mucoadhesion study depicts that as the polymer concentration increased, mucoadhesive nature of the formulation was also increased. The microspheres of NTZ (formulation F9) showed best results due to highest drug entrapment efficiency (85.50%), and percentage drug release after 10.0 hr. was 50.25%. The rate of release followed First order kinetics. The microspheres exhibits good mucoadhesive properties in in- vitro wash-off test at pH 7.4 (Intestinal pH) than pH 1.2 (gastric pH),because the drug was completely absorbed in Gastrointestinal tract, Therefore, it can be concluded that Nitazoxanide Loaded algino-carbopol-934 microspheres can be formulated for sustained drug delivery of Nitazoxanide used in Chronic Hipatitis-C.
Keywords: Mucoadhesive microspheres, Nitazoxanide, Carbopol-934, Ethyl cellulose, Sodium Alginate, Factorial design.
IN-VITRO FREE RADICAL SCAVENGING POTENTIAL OF FLAVONOIDS WITH SYNERGISTIC EFFECT OF THEIR COMBINATION
Authors: Kumar Rajesh , Sharma Shailendra 
Published: September 2018

The present study was carried out to evaluate the possible synergistic interactions on antioxidant efficacy of some selected flavonoids in the present study, synergistic antioxidant effects of two flavonoids, rutin and quercetin, have been investigated by. DPPH, NO, free radical scavenging assays. Biological free radicals are highly unstable molecules that react with various organic substrates such as lipids, proteins, DNA causing cellular injury. At high concentrations, they generate oxidative stress, a damaging process that can damage all cell structures. At present, the research is focused on the use of antioxidants in preventing many diseases caused by the free radicals. The study was designed to evaluate in vitro antioxidant potential of quercetin, rutin, individually and synergistic antioxidant effects by using various in-vitro antioxidant assays i.e. DPPH, NO, assays. The scavenging effect of quercetin, rutin and standard on the DPPH radical was 83±2.71 %, 79±1.51% and 86±1.04 % at 60μg/ml. On NO Quercetin, rutin and standard exhibited 83±0.09 %, 76±0.09 % and 85±0.22%. The scavenging activity increased in a dose dependent manner. The results indicate drugs shows significant free radical scavenging and their combination demonstrated considerable synergistic effect as compared to standard.
Keywords: Quercetin, Rutin, Free radical scavenging, Antioxidant
AN UPDATED REVIEW ON USTUKHUDOOS PLANT
Authors: Siddiqui Aisha , Afrin Zeba , Jafri MA 
Published: September 2018

Lavandula stoechas Mill. commonly known as Ustukhudoos, is perhaps the most important medicinal plant in the unani system of medicine. Whole part, flowers and essential oil of the plant is used to treat a variety of diseases. A number of ailments are treated by the plant which is used either alone or in combination with other plants. It is used for the treatment of various neurological disorders like hemiplegia, facial paralysis, tremors, epilepsy, melancholia, neurasthenia. Moreover, it is used in sinusitis, liver disorders and urinary disorders etc. L. stoechas possesses antimicrobial, antidiabetic, antioxidant, antifungal, anti-inflammatory, anticonvulsant, antispasmodic, sedative, hepatoprotective activities. This article discusses and summarizes the important medicinal values of Ustukhudoos in the perspective of Unani literature as well as modern scientific research.
Keywords: Ustukhudoos, Lavandula stoechas, neurological, epilepsy
REVIEW ON POTENT ANTI-DIABETIC PLANTS OR HERBS FROM TRADITIONAL MEDICINE
Authors: Kolhe Shilpa S. , Rachh Punit  R. 
Published: September 2018

This review focuses on Indian Herbal drugs and plants used in the treatment of diabetes, especially in India. Diabetes is an important human ailment afflicting many from various walks of life in different countries. diabetes is one of the major causes of death and disability in the world. Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity. Due to an increasing demand for chemical diversity in screening programs, seeking therapeutic drugs from natural products, interest particularly in edible plants has grown throughout the world. Botanicals and herbal preparations for medicinal usage contain various types of bioactive compounds. Phytochemicals identified from medicinal plants present an exciting opportunity for the development of new types of therapeutics for diabetes mellitus. Most prevalent among phytochemical groups are the alkaloids, glycosides, polysaccharides, and phenolics such as flavonoids, terpenoids and steroids. These include, Allium sativum, Eugenia jambolana, Momordica charantia Ocimum sanctum, Phyllanthus amarus, Pterocarpus marsupium, Tinospora cordifolia, Trigonella foenum graecum and Withania somnifera.
Keywords: Phytochemicals, diabetes, standardized extracts, bioactive compounds.
OBSTRUCTED PAN CAKE KIDNEY IN A CHILD MANAGED BY IMAGE GUIDED PERCUTANEOUS NEPHROSTOMY
Authors: Kumar Sheo , Mishra Prabhaker , Singh Swish Kumar 
Published: September 2018

Pancake kidney, also called pelvic fused kidney, lump or cake kidney, is a rare type of congenital renal fusion anomaly. It is characterized by the presence of a lobulated pelvic renal mass which has a dual parenchymatous system without an intervening septum. Pancake kidney is prone to obstruction due to abnormal rotation of collecting system and calculus. When a patient presents with a nonfunctioning and obstructed kidney, a temporary nephrostomy preserves any recoverable renal tissue. Many a times a seemingly alarming radiological appearance where little functional recovery is expected, dramatic improvement in renal function has been noticed. We report a case of pancake kidney with right PUJ and left ureteric calculus causing hydronephrosis in a 9-years-old male child, evaluated by ultrasonography and MDCT, underwent image guided (sonography and fluoroscopy) percutaneous nephrostomy for relieving the ureteric obstruction.
Keywords: Renal fusion, pancake kidney, percutaneous nephrostomy, nephrostogram.
ANALYSIS OF PATIENT ADMISSIONS IN HOSPITAL DUE TO ADVERSE DRUG REACTION
Authors: Shete Shivkumar Kashinath , Sattanathan K 
Published: September 2018

The present study is prospective and observational non-interventional study was conducted in tertiary care center. All suspected ADRs which are observed in hospital stay will be assessed for causality, severity, preventability and predictability. The results were presented as number and percentage. Among the 7697 cases ( both males and females), a total of 240 ADRs were detected, an overall incidence of 03.11 % adverse drug reactions in inpatients. The high prevalence of ADR mostly observed in the age group between 1-10 years 48 (20.00%) From this 240 ADR’s where 7.96% on continuing t, 38.36% are recovering, 47.08% are recovered.
Keywords: Adverse drug reaction, Causality, Severity, Preventability, Probability.
The Traditional Approaches for the Management of Mental Diseases W.S.R. to Indigenous Herbs in Manovikara
Authors: Vaidya Chaitanya H. 
Published: September 2018

The uses of ayurveda not only reside around as main stream of ancient science but it also served as complementary or alternate medicine. Ayurveda provides principles to maintain good healthy status of mind, body and soul. Ayurveda also offer therapies for the management of mental health issues including; shodhna therapy, use of herbs & formulation and yoga therapy. The use of indigenous herbs & plants greatly recommended by ancient acharya in mental illness such as; Bacopa monnieri, Centella asiatica, Amla, Mucuna, Zizyphus jujube, Kava and Saffron. This article describe role of indigenous herbs and traditional medicine in the management of mental problems.
Keywords: Ayurveda, Mental Health, Kaya-Chikitsa, Indigenous Herbs and Swasthya.
Physicochemical and Microbiological Assays for Quality Evaluation of a Brand of Mentha piperita Tisanes in Costa Rica Market: Employment of the Central American Technical Regulation
Authors: Mora Román Juan José , Agüero Brenes Natalia , Angulo Morales Camila , Castro Solís Jose , Hidalgo Carrillo Gabriela , Van Hoof Gómez Mónica , Loría Gutiérrez Arlene , Blanco Barrantes Jeimy 
Published: September 2018

Mentha piperita is a natural hybrid of water mint (Mentha aquatica) and spearmint (Mentha spicata L.), that are consumed as tisanes. For that reason, the present work evaluated physicochemical and microbiological aspects for the quality control of a commercial brand of Mentha piperita herbal tea distributed in Costa Rica, using assays established by the Central American Technical Regulation (RTCA) 11.03.56.09 (Pharmaceutical products. Natural medicinal products for human use. Quality verification), and determined if they have uniformity for different batches of this brand. To verify the quality of three batches of this product, the following assays were done: Labeling requirements, organoleptic, minimum fill, foreign organic matter, loss on drying, total ash, acid-insoluble ash, lead and arsenic limits, microbial enumerations and specific microorganisms (E. coli and Salmonella sp.) assays. As conclusion, the batches were in compliance for all the assays, except for labeling test, since information corresponding to the primary (batch number and expiration date) and secondary packaging (qualitative-quantitative composition of active ingredients interactions and adverse effects) were not presented. Furthermore, one of the batches did not have information about the employment, contraindications and warnings. Also, the manufacturing company maintained a good reproducibility between one batch and another, and the improvements that can be made are in the product labeling and better controls in its filling.
Keywords: Natural product, Mentha piperita, quality control, tisane, pharmacopoeia, Central American Technical Regulation.