bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding subsurface fluvial architecture from a combination of geological well test models and well test data
Authors: Corbett Patrick William Michael , Duarte Gleyden Lucila Benítez 
Published: December 2018

Abstract
Two decades of geological modelling have resulted in the ability to study single-well geological models at a sufficiently high resolution to generate synthetic well test responses from numerical simulations in realistic geological models covering a range of fluvial styles. These 3D subsurface models are useful in aiding our understanding and mapping of the geological variation (as quantified by porosity and permeability contrasts) in the near-wellbore region. The building and analysis of these models enables many workflow steps, from matching well test data to improving history-matching. Well testing also has a key potential role in reservoir characterization for an improved understanding of the near-wellbore subsurface architecture in fluvial systems. Developing an understanding of well test responses from simple through increasingly more complex geological scenarios leads to a realistic, real-life challenge: a well test in a small fluvial reservoir. The geological well testing approach explained here, through a recent fluvial case study in South America, is considered to be useful in improving our understanding of reservoir performance. This approach should lead to more geologically and petrophysically consistent models, and to geologically assisted models that are both more correct and quicker to match to history, and thus, ultimately, to more useful reservoir models. It also allows the testing of a more complex geological model through the well test response.
Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress–Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer
Authors: Bagheri-Yarmand Rozita , Sinha Krishna M. , Li Ling , Lu Yue , Cote Gilbert J. , Sherman Steven I. , Gagel Robert F. 
Published: December 2018

Abstract

Medullary thyroid carcinoma (MTC) originates from the C cells of the thyroid gland, which secrete calcitonin. Lymph node and distant metastases are frequently present at diagnosis. Activating mutations of RET, a driver oncogene in MTC that encodes a tyrosine kinase receptor, prevents apoptosis through inhibition of ATF4, a key transcriptional regulator of endoplasmic reticulum (ER) stress. We hypothesized that the combination of a tyrosine kinase inhibitor (TKI) and an ATF4 inducer promotes cell death by triggering catastrophic oxidative stress and apoptotic cell death. Here, we report that the ER-associated protein degradation (ERAD) inhibitor eeyarestatin sensitized MTC cells to the TKIs, sunitinib and vandetanib, thereby leading to synergistic upregulation of ATF4 expression, accumulation of reactive oxygen species, and subsequent cell death. Genome-wide analysis of ATF4 interaction sites by chromatin immunoprecipitation (ChIP) sequencing revealed that among ATF4 target genes was KLF9 (Kruppel-like factor 9), which induces MTC apoptosis. ChIP assays revealed that ATF4 occupancy at the KLF9 promoter was increased in MTC cells treated with eeyarestatin or vandetanib alone and was further enhanced in cells treated with both drugs, leading to increased KLF9 transcription. Depletion of ATF4 by shRNA led to downregulation of KLF9 expression and prevented oxidative stress–induced cell death. Furthermore, we identified ATF4 target genes (LZTFL1, MKNK2, and SIAH1 with known tumor suppressor function) that were synergistically upregulated with the combination of TKI and ERAD inhibitor.

Implications:
These findings reveal a combination therapy that induces reactive oxygen species–dependent catastrophic cell death through induction of ATF4 and KLF9 transcriptional activity.
Avaliação da eficácia de hidrofugantes e antigraffiti no Arenito Itararé
Authors: Grossi Danielle , Del Lama Eliane Aparecida 
Published: December 2018

No patrimônio pétreo, a rocha está exposta aos efeitos do intemperismo. Para postergar esse processo, existem produtos de tratamento e proteção, os quais devem ser testados e aprovados, pois podem danificar mais o patrimônio do que o próprio intemperismo se os produtos não forem compatíveis com a rocha. O Theatro Municipal de São Paulo, uma importante edificação do Centro Velho da cidade de São Paulo, possui o Arenito Itararé em sua fachada frontal. Essa é uma rocha muito frágil devido à presença de esmectita em sua composição. Esse mineral se degrada muito facilmente em presença de água. Visando estudar um meio de proteger essa rocha contra a ação da água, dois hidrofugantes (siloxano — H1 — e propil siliconato oligomérico — H2) foram testados. Outro problema que atinge os centros urbanos é o vandalismo por graffiti/pichação. Como essa é uma rocha porosa, a limpeza desse tipo de ação não é totalmente efetiva e os produtos utilizados deixam resíduos que prejudicam a durabilidade da pedra. Para proteger a rocha da pichação, também foi testado um antigraffiti (AG). Para avaliar a eficiência desses produtos, foram realizados ensaios de capilaridade, tubo de Karsten, medida do ângulo de contato, microscopia eletrônica de varredura, porosimetria de mercúrio, ciclos de saturação e secagem, velocidade de ondas ultrassônicas, espectrofotometria e profundidade de penetração. Os hidrofugantes mostraram comportamentos similares, entretanto o H1 diminuiu a porosidade da rocha e não polimerizou completamente. O antigrafitti escureceu a rocha e mudou a distribuição do tamanho dos poros.
Prognostic Impact of Periprocedural Myocardial Infarction in Patients Undergoing Elective Percutaneous Coronary Interventions
Authors: Koskinas Konstantinos C. , Ndrepepa Gjin , Räber Lorenz , Karagiannis Alexios , Kufner Sebastian , Zanchin Thomas , Hieber Julia , Hunziker Lukas , Mayer Katharina , Byrne Robert A. , Heg Dik , Windecker Stephan , Kastrati Adnan 
Published: December 2018

Background:
The magnitude of prognostically relevant myocardial injury after percutaneous coronary interventions remains poorly defined. The Society for Cardiovascular Angiography and Interventions (SCAI) proposed marked biomarker elevations to define periprocedural myocardial infarction (PMI). These consensus-based thresholds have not been validated in the era of high-sensitivity cardiac troponins. We sought to assess the prognostic impact of SCAI-defined PMI and explore optimal prognostic thresholds of high-sensitivity cardiac troponin T (hs-cTnT) after elective percutaneous coronary interventions.

Methods and Results:

We evaluated patients who underwent elective percutaneous coronary interventions at 2 tertiary care centers with serial hs-cTnT measurements. PMI was defined as peak postprocedural hs-cTnT >70× upper reference limit (URL) in patients with nonelevated (≤1× URL) baseline levels; or incremental increase >70× URL in patients with elevated baseline levels. The primary outcome was 1-year all-cause mortality. Of 8140 patients, 220 (2.7%) died within 1 year. In multivariable analyses, patients with SCAI-defined PMI (n=140; 1.7%) had a higher risk of 1-year mortality (12.9% versus 2.5%, adjusted hazard ratio 4.10, 95% CI 2.51–6.68;
P
<0.001) as well as cardiac mortality (11.4% versus 2.1%, adjusted hazard ratio 4.21, 95% CI 2.50–7.11;
P
<0.001). Based on receiver operating characteristics analysis, the optimal prognostic threshold of hs-cTnT was >10×URL, observed in 14.6% of patients. This threshold showed lower specificity (85.7% versus 98.4%) but higher sensitivity (25.4% versus 8.2%) and better overall performance for prediction of 1-year mortality compared with the SCAI-defined cutoff value of troponin.

Conclusions:
In patients undergoing elective percutaneous coronary interventions, SCAI-defined PMI emerged as an independent, highly specific, but insensitive predictor of 1-year mortality. Optimal trade-off between sensitivity and specificity was observed at a lower threshold of hs-cTnT (10× URL) in this cohort.
Familial Mortality Risks in Patients With Heart Failure—A Swedish Sibling Study
Authors: Lindgren Magnus P. , Smith J. Gustav , Li Xinjun , Sundquist Jan , Sundquist Kristina , Zöller Bengt 
Published: December 2018

Background

The influence of familial factors on the prognosis of heart failure (
HF
) is unknown. This nationwide follow‐up study aimed to determine familial mortality risks of
HF
among Swedish siblings hospitalized for
HF
.

Methods and Results

We linked several Swedish nationwide registers for individuals aged 0 to 80 years. The study population consisted of 373 people hospitalized for
HF
for the first time between 2000 and 2012 with 1 proband sibling previously hospitalized for
HF
for the first time between 2000 and 2007. Families with congenital heart disease were excluded. Familial hazard ratios (
HR
s) for mortality after first
HF
hospitalization were determined with Cox regression. The influence of proband survival was categorized as short survival (<5 years) or long survival (≥5 years) and determined continuously for the initial 5 years of proband survival. Adjustments were made for age, sex, time period, and common
HF
comorbidities. Short proband survival was associated with a
HR
of 2.02 (95% confidence interval, 1.32–3.09) for overall mortality. This
HR
was 2.35 (95% confidence interval, 1.18–4.67) in patients without preceding coronary heart disease, whereas patients with ischemic
HF
had an
HR
of 1.84 (95% confidence interval, 1.05–3.23). For each year of proband survival, the risk of death decreased, with a
HR
of 0.86 (95% confidence interval, 0.77–0.98).

Conclusions

Our results suggest that family history of poor survival in specific relation to
HF
is an important risk factor for death in
HF
patients. Additional studies are needed to characterize the molecular underpinnings and detailed phenotypic characteristics of such patients.
“As if she were Jerusalem”: Placemaking in Sephardic Salonica
Authors: Christensen Peter 
Published: December 2018

No Mediterranean city witnessed as dramatic a demographic shift as Salonica following the expulsion of the Jews from Iberia in 1492. This article explores the specific concept of placemaking in the context of this transformation, examining how the industries, devotional spaces, mythology, and material traditions of Iberian Jews tactically engaged with extant forms of Ottoman multicultural governance and social systems. Drawing upon a broad array of visual and textual information, this article argues that under the evolving mechanics of the millet and dhimmi systems, the nimbler aspects of material culture–color, fabric, dress, spoliation–proved to be the most effective in articulating and developing diasporic Sephardic identity within both the city and the empire. This article further analyzes the ways in which this identity was capable of, if not inclined to, the delimiting of regional, class, and gender groups, ultimately contouring and challenging notions of a monolithic minority culture within the Ottoman Empire from the sixteenth through the early nineteenth century.
A Tale of Two Mosques: Marrakesh’s Masjid al-Jamiʿ al-Kutubiyya
Authors: Stockstill Abbey 
Published: December 2018

Abstract
The Kutubiyya Mosque, the hallmark monument of the Almohad dynasty (1121–1269) in their capital city of Marrakesh, has resisted scholarly interpretation due to its unique plan, featuring two prayer halls wedged apart by the monumental minaret. The south-facing qibla and the architectural use of a prior dynasty’s palatial remains further complicate the narrative surrounding the function of the mosque within the urban fabric and the Almohads’ dynastic self-concept. This article argues that such idiosyncrasies are indicative of the Almohads’ sensitivity to the intellectual, religious, and legal arguments of the day, expressed through a deliberate adaptation or repudiation of the architectural precedents in the Islamic West. The Kutubiyya must be understood as a monumental record of the dynastic shifts in ideology and identity as the Almohads struggled to define themselves against their predecessors and competitors. The site’s unique plan and complex construction history are the physical evidence of this struggle, which makes the role of the Kutubiyya in the urban history of Marrakesh all the more significant.
An Unknown Collection of Preliminary Drawings and Extra Illustrations Prepared for The Arabian Antiquities of Spain by James Cavanah Murphy in the Gennadius Library, Athens
Authors: Mulvin Lynda S. 
Published: December 2018

Abstract
In the Gennadius Library of the American School of Classical Studies at Athens, Greece, is a heretofore unknown large-format volume that contains many extra illustrations, original drawings, and proofs of plates for The Arabian Antiquities of Spain by James Cavanah Murphy (1760–1814). Based on research conducted between 1802 and 1809, The Arabian Antiquities of Spain features engravings of major monuments of Hispano-Islamic architecture, including the Alhambra, the Great Mosque at Cordoba, and the Generalife at Granada; the work was published posthumously in 1816. Since the Gennadius volume also includes sketches of Islamic monuments from Malaga, Seville, and Xeres, it appears that Murphy originally intended to publish a complete survey of Hispano-Islamic monuments in southern Spain. In the Gennadius volume, grangerized drawings are placed opposite published engravings for comparative purposes; the drawings include notes written by Murphy to the engravers, and several are hand-tinted, which reveal Murphy’s interest in polychromy. This article presents the newly discovered drawings in the Gennadius volume, which adds to our understanding of the monuments depicted in the published plates of Arabian Antiquities, and serves to position Murphy’s pioneering efforts in the context of architectural scholarship, chromolithography, and the book trade in the early nineteenth century.
Investment Protection in Offshore Energy Production: Bright Sides of Regime Interaction
Authors: Trevisanut Seline , Giannopoulos Nikolaos 
Published: December 2018

Abstract
At the international law level, the regulation of offshore energy projects does not fall neatly into one global regime. On the contrary, it is subject to a plethora of overlapping legal regimes, including the law of the sea, international environmental law, international economic law, and international energy law. The present article addresses the question how regime interaction affects investment protection in the offshore energy sector. Specifically, it investigates whether cross-fertilization between regimes also has ‘positive’ effects on the protection of investments in offshore energy or whether fragmentation consists of both a perceived and actual challenge. We submit that, even though regime interaction poses challenges to investment protection, the influence of the overlapping legal frameworks is not necessarily a ‘threat’ to investment protection. To the contrary, regime interaction can contribute to widen the objectives of international investment law.
Comparing glomerular filtration rate equations and the impact of different creatinine assays on the assessment of renal function in cancer patients
Authors: Garner Ashley E , Barnfield Mark C , Waller Michael L , Hall Geoff D , Bosomworth Mike P 
Published: December 2018

Background Equations to estimate glomerular filtration rate based on serum creatinine are commonly used in cancer patients to assess renal function. However, there is uncertainty regarding which equation is most appropriate for this population and the impact of different creatinine assays. Methods Measured isotopic glomerular filtration rate results from 120 oncology patients were used to evaluate and compare all four versions of the Wright equation, Cockcroft and Gault, Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration and the Janowitz and Williams formula; using eight different creatinine assays (five Jaffe, three enzymatic). Results The enzymatic version of the Wright equation without creatine kinase performed better than the other versions for all eight creatinine assays. However, MDRD and Janowitz and Williams gave the best overall performance in this patient population. Performance was highly dependent on the creatinine assay used, for example, the percentage of results within 30% of the isotopic glomerular filtration rate (P30) ranged from 90.8% to 60.8% for MDRD. Conclusion The performance of any equation to estimate glomerular filtration rate is highly dependent on the creatinine assay used. Oncology units should assess the performance of glomerular filtration rate equations using their laboratory creatinine assay to determine whether they can be used safely and effectively in cancer patients.
L’ergothérapie à l’ère de la quatrième révolution industrielle
Authors: Liu Lili 
Published: December 2018

Description. Bien que l’ergothérapie soit issue du mouvement Arts and Crafts et du traitement du moral des anciens combattants, la profession a évolué vers l’adoption de la maîtrise préalable à l’entrée en exercice de la pratique et elle fait appel à l’établissement de relations complexes avec les clients tout au long de la vie. À travers l’histoire, chacune des révolutions industrielles a eu un impact systématique, soit une perte massive d’emplois en raison de l’automatisation des processus. Cette conséquence est encore plus profonde aujourd’hui avec la croissance exponentielle des innovations et de l’automatisation. But. Les objectifs de cet article sont (a) de faire une mise en contexte en examinant l’évolution ou les cinq ères de l’ergothérapie au Canada, (b) de définir ce que l’on entend par « quatrième révolution industrielle », et (c) d’examiner les innovations technologiques qui auront une influence sur les ergothérapeutes et leurs clients alors que nous entrons dans la « sixième » ère de l’ergothérapie au Canada. Questions clés. Bien que le risque d’automatisation de la profession d’ergothérapeute soit faible, un grand nombre de nos clients seront incapables d’acquérir assez rapidement les nouvelles compétences qui seront requises pour répondre aux exigences du marché de l’emploi. La téléréadaptation, l’Internet des objets, la réalité virtuelle, l’impression 3D, la robotique, l’intelligence artificielle et les véhicules autonomes sont en train de transformer la façon dont les ergothérapeutes offrent des services aux clients. Conséquences. Il serait judicieux pour les ergothérapeutes de s’allier à des disciplines différentes de celles avec lesquelles ils collaborent habituellement, car leur expertise sera sollicitée pour défendre leurs propres intérêts et ceux de leurs clients, qui sont les utilisateurs finaux de ces technologies.
Charting Success: The Experience of Teachers of Students with Visual Impairments in Promoting Student Use of Graphics
Authors: Zebehazy Kim T. , Wilton Adam P. 
Published: December 2018

Introduction This study analyzed the qualitative responses of a survey of teachers of students with visual impairments in Canada and the United States about tactile and print graphic use by their students with visual impairments. Questions focused on barriers to students using graphics, strategies taught to tactile graphics users, and profiles of successful tactile and print graphics users. Methods The researchers followed a thematic analysis approach to independently code and then reach consensus on themes and subthemes of the qualitative responses. Results In general, the teachers cited a range of challenges under the main themes of quality and instruction. Subcategories included availability of time for both production and instruction, lack of standardization in material production, and student development of concepts through the use of graphics. Main characteristics of successful graphics users included motivation and an ability to apply skills across tasks. Variations in responses for tactile and print graphics users are highlighted. Discussion Findings highlighted areas in which teachers of students with visual impairments can focus to promote effective graphics use by their students. Commonality in strategies used for teaching tactile graphics was apparent, as was a general belief that being intelligent contributed to success. Implications for practitioners Frequent exposure and practice with graphics, whether tactile or print, is important. Developing an ability to analyze the features of a graphic and its impact on comprehension can inform strategies for and selection of instructional methods.
Postural Control in Young People with Visual Impairments and Various Risks of Falls
Authors: Sadowska Dorota , Stemplewski Rafał , Szeklicki Robert 
Published: December 2018

Introduction Early diagnosis of postural control deficiencies facilitates implementation of an individual rehabilitation plan to prevent falls. The aim of the study was to assess the risk of falling in individuals with visual impairments, and to compare performance-based and theoretical limits of stability in subjects with various risks of falling. Methods The study was comprised of 23 participants with severe visual impairments. The risk of fall was assessed with the Step Test. Performance-based limits of stability were measured with the Advanced Mechanical Technology, Inc. (AMTI) platform, and theoretical limits of stability were calculated based on the height of the center of mass (COM) and maximum body sway leaning angles. Results COM displacement values, corresponding to performance-based limits of stability, in individuals with visual impairments whose risk of falling was classified as high were significantly lower than the theoretical values (p ≤ .05). Similar differences were not observed in participants with visual impairments whose risk of falling was assessed as low. Individuals from the low-risk group showed significantly higher values of performance-based limits of stability than the participants from the high-risk group (p ≤ .01 for medio-lateral direction and p ≤ .05 for forward-backward direction). Discussion Nearly half of young people with visual impairments are at increased risk of falling. Such persons showed lower performance-based limits of stability than participants with visual impairments with a low risk of falling. Performance-based limits of stability in individuals with visual impairments with a high risk of falling are lower than their theoretical limits of stability. Implications for practitioners The fact that nearly half of young people with visual impairments are at an increased risk of falling necessitates implementation of preventive measures in this group, as well as among individuals who are blind.