bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current and Future Perspectives on Children’s Genetic- and Endophenotype-Based Differential Susceptibility to Parenting
Authors: Fischer Karen , Weeland Joyce , Leijten Patty , van den Akker Alithe , Overbeek Geertjan 
Published: October 2019

Abstract

Objectives
Accumulating research provides support for differential susceptibility, which holds that the same children who are most vulnerable to adversity, such as negative parenting, may also benefit most from enriched environments, such as positive parenting. This “for better and for worse” phenomenon is believed to be rooted in endogenous, biological susceptibility factors such as genes, and cognitive and physiological endophenotypes (e.g., heart rate variability and skin conductance). The goal of this paper is to discuss the effect of this biological perspective on children’s susceptibility, and the inclusion of genetic and endophenotypical data in parenting research to shed light on the differential effects of parenting behavior We discuss a number of conceptual and methodological issues related to prior studies that have aimed to assess this.

Methods
We review and discuss current and future perspectives on children’s genetic- and endophenotype-based differential susceptibility to parenting, and experimental study designs that can adequately assess the within-person phenomenon of differential susceptibility.

Results
We summarize our call for research in an experimental paradigm to test children’s gene- and endophenotype-based differential susceptibility to parenting in their development of externalizing behavior.

Conclusions
Hereby we aim to advance our understanding of the biological mechanisms underlying children’s differential susceptibility to negative and positive parenting.
l-Arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway
Authors: Xia Zhaofei , Huang Liqing , Yin Peng , Liu Fenghua , Liu Yanhan , Zhang Zhenbiao , Lin Jiabao , Zou Wenshu , Li Chunxiao 
Published: October 2019

Abstract
Heat stress (HS) and secondary restricted blood flow to the intestines cause dysfunction of the intestinal epithelial barrier. Tight junctions (TJs) are essential to maintain intestinal integrity. l-Arginine has beneficial effects on gut functions. However, the underlying mechanisms remain largely unknown. This study tested the hypothesis that l-arginine regulates the TJ network by activating AMP-activated protein kinase (AMPK) signaling, which in turn improves intestinal barrier functions under HS. IEC-6 cells and rat small intestines were used as experiment models of heat stress. AICAR and dorsomorphin were used to activate and inhibit the AMPK pathway, respectively. Cell proliferation, apoptosis, differential gene expression and KEGG pathway analysis, intestinal paracellular permeability, intestinal morphology, and expression of HSP and TJ proteins, and p-AMPK were determined. l-Arginine promoted cell proliferation and reduced apoptosis after heat exposure at an optimal concentration of 5 mmol. Transcriptome sequencing analysis revealed that differentially expressed genes associated with the HSP family and TJs were elevated by l-arginine. According to KEGG pathway analysis, l-arginine activated the AMPK signaling pathway. In vivo, intestinal damage resulted in obvious morphological changes as well as apoptosis with TUNEL and caspase-3 staining under HS and dorsomorphin treatments. Furthermore, HS and dorsomorphin increased the serum D-lactate concentration, diamine oxidase activity, and mRNA expression level of MLCK (P < 0.05). In contrast, l-arginine and AICAR treatments reduced intestinal injury, maintained intestinal permeability, and increased the villus/crypt ratio under hyperthermia. l-Arginine had the same effect as AICAR both in vitro and in vivo, namely increasing p-AMPK protein expression. l-Arginine and AICAR also upregulated the mRNA expression level of HSP70 and HSP90, and downregulated mRNA expression of MLCK (P < 0.05). The protein expression levels of TJ proteins ZO-1 and claudin-1 were suppressed by heat stroke and dorsomorphin, but enhanced by l-arginine and AICAR. Our findings indicate that activation of AMPK signaling by l-arginine is associated with improved intestinal mucosal barrier functions by enhancing the expression of TJs in rat small intestines and IEC-6 cells during HS.
Factors contributing to the ceiling effect of the EQ-5D-5L: an analysis of patients with prostate cancer judged “no-problems”
Authors: Murasawa Hideki , Sugiyama Takayuki , Matsuoka Yuki , Okabe Takashi , Wakumoto Yoshiaki , Tanaka Nobumichi , Sugimoto Mikio , Oyama Masafumi , Fujimoto Kiyohide , Horie Shigeo , Funagoshi Masaru , Arakawa Ichiro , Noto Shinichi , Shimozuma Kojiro 
Published: October 2019

AbstractPurposeThe goal of the present study was to determine factors related to a ceiling effect (CE) on the EQ-5D-5L among Japanese patients with prostate cancer (PC).MethodsAn existent cross-sectional observational study dataset was used. Patients were ≥ 20 years of age and diagnosed with PC. For CE determinants on the EQ-5D-5L, we excluded possible “full-health” patients flagged by the EQ-VAS (score = 100) and/or FACT-P (score = 156) instruments. We then divided them into binary variables: A CE group (EQ-5D-5L score = 1) and others (< 1). The associations between CE, sociodemographic and medical characteristics, and FACT-P subscale scores were examined using a multivariate LASSO selection followed by a binomial logistic regression analysis performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs).ResultsA total of 362 patients were analyzed. The LASSO selection variables, including all obtained variables, were as follows: age, palliative treatment, FACT-P physical well-being, and PC subscale score. Statistically significant variables predicting CE were palliative treatment (OR 0.23; 95% CI 0.09–0.60), physical well-being (OR 1.54; 95% CI 1.34–1.76), and PC subscale (OR 1.08; 95% CI 1.03–1.14).ConclusionsThis study revealed that palliative treatment and two FACT-P physical well-being and PC subscale scores were positively related to CE on the EQ-5D-5L. To our knowledge, this is the first study to examine predictors of CE on the EQ-5D-5L. The present results may be helpful for facilitating the consideration of “bolt-on” studies from the standpoint of PC patients.
The Role of Value Deliberation to Improve Stakeholder Participation in Issues of Water Governance
Authors: Pigmans Klara , Aldewereld Huib , Dignum Virginia , Doorn Neelke 
Published: October 2019

AbstractStakeholder participation is a requirement for environmental decision-making in the European Union. Despite this, numerous instances can be seen in water governance in which stakeholders feel undervalued and unheard, thereby creating unfavourable procedural outcomes, resistance and conflict. In this article, we propose that a process of early-stage deliberation constructed around the values of the stakeholders involved can reduce, and even prevent such conflicts. We suggest that if values that stakeholders perceive as relevant can be identified and discussed as part of the deliberation process then (1) stakeholder preferences can change, and (2) participants can develop a mutual understanding of each other’s values and perspectives. To explore these propositions, facilitated workshops were conducted at two Dutch water institutes, based around the topics of land subsidence and the pharmaceutical contamination of water systems. Participants deliberated on values that they considered relevant. The results suggest that mutual understanding of stakeholders’ perspectives increases as a result of value-based deliberation.
Inhibition of Hypothalamic MCT4 and MCT1–MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions
Authors: Elizondo-Vega Roberto , Oyarce Karina , Salgado Magdiel , Barahona María José , Recabal Antonia , Ordenes Patricio , López Sergio , Pincheira Roxana , Luz-Crawford Patricia , García-Robles María Angeles 
Published: October 2019

Abstract
Feeding behavior regulation is a complex process, which depends on the central integration of different signals, such as glucose, leptin, and ghrelin. Recent studies have shown that glial cells known as tanycytes that border the basal third ventricle (3V) detect glucose and then use glucose-derived signaling to inform energy status to arcuate nucleus (ARC) neurons to regulate feeding behavior. Monocarboxylate transporters (MCT) 1 and MCT4 are localized in the cellular processes of tanycytes, which could facilitate monocarboxylate release to orexigenic and anorexigenic neurons. We hypothesize that MCT1 and MCT4 inhibitions could alter the metabolic communication between tanycytes and ARC neurons, affecting feeding behavior. We have previously shown that MCT1 knockdown rats eat more and exhibit altered satiety parameters. Here, we generate MCT4 knockdown rats and MCT1–MCT4 double knockdown rats using adenovirus-mediated transduction of a shRNA into the 3V. Feeding behavior was evaluated in MCT4 and double knockdown animals, and neuropeptide expression in response to intracerebroventricular glucose administration was measured. MCT4 inhibition produced a decrease in food intake, contrary to double knockdown. MCT4 inhibition was accompanied by a decrease in eating rate and mean meal size and an increase in mean meal duration, parameters that are not changed in the double knockdown animals with exception of eating rate. Finally, we observed a loss in glucose regulation of orexigenic neuropeptides and abnormal expression of anorexigenic neuropeptides in response to fasting when these transporters are inhibited. Taken together, these results indicate that MCT1 and MCT4 expressions in tanycytes play a role in feeding behavior regulation.
The Effect of Aeration for 6-Pentyl-alpha-pyrone, Conidia and Lytic Enzymes Production by Trichoderma asperellum Strains Grown in Solid-State Fermentation
Authors: Hamrouni Rayhane , Molinet Josiane , Dupuy Nathalie , Taieb Nadira , Carboue Quentin , Masmoudi Ahmed , Roussos Sevastianos 
Published: October 2019

AbstractIn recent years, the production of biopesticides has gained great attention in the scientific word because it is an important alternative to replace the much debated chemical pesticides used on the field crops. Fungal lytic enzymes, conidia and secondary metabolites like 6 pentyl-alpha-pyrone (6-PP) play a very important role in the biological control of pests. On the present study, the influence of application of air through a solid-state fermentation using threeTrichoderma asperellumstrains to produce conidia, 6-PP and essential enzymes were evaluated. A mix of vine shoots, potatoes flour, jatropha, olive pomace and olive oil as substrates was used.T. asperellumTV104 showed the best 6-PP production (3.06 ± 0.15 mg g DM−1), cellulases activities (34.3 ± 0.4 U g−1), and amylase activity (46.3 ± 0.6 U g−1) however,T. asperellumTF1 produced the higher levels of lipase (30.6 ± 0.3 U g−1), under air conditions. The production of these same enzymes was less efficient without the application of forced aeration. The forced aeration increased the conidia production, the best value was observed withT. asperellumTF1 (2.23 ± 0.07 × 109 g DM−1).Graphic Abstract
Can investments in manure technology reduce nutrient leakage to the Baltic Sea?
Authors: Jansson Torbjörn , Andersen Hans Estrup , Hasler Berit , Höglind Lisa , Gustafsson Bo G. 
Published: October 2019

Abstract
In this study, quantitative models of the agricultural sector and nutrient transport and cycling are used to analyse the impacts in the Baltic Sea of replacing the current Greening measures of the EU’s Common Agricultural Policy with a package of investments in manure handling. The investments aim at improving nutrient utilization and reducing nitrogen leaching, based on the assumption that lagging farms and regions can catch up with observed good practice. Our results indicate that such investments could reduce nitrogen surpluses in agriculture by 18% and nitrogen concentrations in the Baltic Sea by 1 to 9% depending on the basin. The Greening measures, in contrast, are found to actually increase nitrogen leaching.
Cross-Sectoral Big Data
Authors: Laurie Graeme T. 
Published: October 2019

Abstract
Discussion of uses of biomedical data often proceeds on the assumption that the data are generated and shared solely or largely within the health sector. However, this assumption must be challenged because increasingly large amounts of health and well-being data are being gathered and deployed in cross-sectoral contexts such as social media and through the internet of (medical) things and wearable devices. Cross-sectoral sharing of data thus refers to the generation, use and linkage of biomedical data beyond the health sector. This paper considers the challenges that arise from this phenomenon. If we are to benefit fully, it is important to consider which ethical values are at stake and to reflect on ways to resolve emerging ethical issues across ecosystems where values, laws and cultures might be quite distinct. In considering such issues, this paper applies the deliberative balancing approach of the Ethics Framework for Big Data in Health and Research (Xafis et al. 2019) to the domain of cross-sectoral big data. Please refer to that article for more information on how this framework is to be used, including a full explanation of the key values involved and the balancing approach used in the case study at the end.
Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults
Authors: Ogino Erika , Manly Jennifer J. , Schupf Nicole , Mayeux Richard , Gu Yian 
Published: October 2019

AbstractIntroductionThe associations between self‐reported current and past leisure time physical activity (LTPA) and Alzheimer's disease (AD) incidence were determined using data from the multiethnic Washington/Hamilton Heights‐Inwood Columbia Aging Project (WHICAP) study.MethodsThe metabolic equivalent of LTPA energy expenditure was calculated for self‐reported current and past LTPA for 1345 older adults. A Cox proportional hazard model was conducted to estimate the association between LTPA (low, middle, and high) and incident AD risk.ResultsComparing high to low level, current and past LTPA were both associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.39 (0.20–0.75) and 0.37 (0.18–0.75), respectively. Compared with “always low,” “increased” and “always high” LTPA throughout life were associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.60 (0.36–0.99) and 0.28 (0.08–0.94), respectively. Light‐ and moderate‐intensity LTPA were associated with lower AD risk.DiscussionLTPA both throughout life and later in life are associated with lower risk of AD.
State Patriotism and Jewish Nationalism in the Late Russian Empire: The Case of Vladimir Jabotinsky’s Journalist Writing on The Russo–Japanese War, 1904–1905
Authors: Shumsky Dmitry 
Published: October 2019

AbstractIn his autobiographical writings, the Russian-Jewish author and the founder of Zionist Revisionism Vladimir Jabotinsky constructed a retrospective self-image, according to which ever since becoming a Zionist early in the 20th century he exclusively clung to a Jewish national identity. This one-dimensional image was adopted by the early historiography of the Revisionist movement in Zionism. Contrary to this trend, much of the recent historiography on Jabotinsky has taken a different direction, describing him, particularly as a young man during the period of his early Zionism in Tsarist Russia, as a Russian-European cosmopolitan intellectual. Both these polarized positions are somewhat unbalanced and simplistic, whereas the figure of Jabotinsky and his worldview that emerge from reading his rich publicist writing in late Tsarist Russia present a far more complex picture of interplay between his deep ethnic-national primordial Jewish affinity, on the one hand, and an array of his different attachments to his non-Jewish surroundings including local, cultural, and civil identities, on the other. Focusing on Jabotinsky’s unexplored journalist writings that address the Russo-Japanese war of 1904–1905, the article discovers a previously unknown identity pattern of the young Jabotinsky—his Russian state patriotism—and traces its relationship to his Jewish nationalism.
Comprehensive comparison of social cognitive performance in autism spectrum disorder and schizophrenia
Authors: Pinkham Amy E. , Morrison Kerrianne E. , Penn David L. , Harvey Philip D. , Kelsven Skylar , Ludwig Kelsey , Sasson Noah J. 
Published: October 2019

AbstractBackgroundAutism spectrum disorder (ASD) and schizophrenia (SCZ) are separate neurodevelopmental disorders that are both characterized by difficulties in social cognition and social functioning. Due to methodological confounds, the degree of similarity in social cognitive impairments across these two disorders is currently unknown. This study therefore conducted a comprehensive comparison of social cognitive ability in ASD and SCZ to aid efforts to develop optimized treatment programs.MethodsIn total, 101 individuals with ASD, 92 individuals with SCZ or schizoaffective disorder, and 101 typically developing (TD) controls, all with measured intelligence in the normal range and a mean age of 25.47 years, completed a large battery of psychometrically validated social cognitive assessments spanning the domains of emotion recognition, social perception, mental state attribution, and attributional style.ResultsBoth ASD and SCZ performed worse than TD controls, and very few differences were evident between the two clinical groups, with effect sizes (Cohen's d) ranging from 0.01 to 0.34. For those effects that did reach statistical significance, such as greater hostility in the SCZ group, controlling for symptom severity rendered them non-significant, suggesting that clinical distinctions may underlie these social cognitive differences. Additionally, the strength of the relationship between neurocognitive and social cognitive performance was of similar, moderate size for ASD and SCZ.ConclusionsFindings largely suggest comparable levels of social cognitive impairment in ASD and SCZ, which may support the use of existing social cognitive interventions across disorders. However, future work is needed to determine whether the mechanisms underlying these shared impairments are also similar or if these common behavioral profiles may emerge via different pathways.
Implementing digital game-enhanced pedagogy: Supportive and impeding language awareness and discourse participation phenomena
Authors: McNeil Levi 
Published: October 2019

AbstractThis descriptive study investigated the implementation of student-selected, entertainment-purposed digital games for foreign language teaching and learning. During a 15-week semester, 16 Korean EFL students enrolled in an introductory educational technology course played online games, visited gaming sites, and completed instructional tasks. Conceptualizing games as social practices and drawing from the bridging activities framework (Thorne & Reinhardt, 2008), instructional tasks were designed to enhance language awareness and to present possibilities for socialization into gaming discourses. The study investigated the ways that the designed pedagogy supported or impeded language awareness and gaming discourse participation. The study found that the students exhibited language awareness in many ways, but that there were missed opportunities in developing student understandings of language as a social medium. Additionally, six students (38%) directly participated in gaming spaces, and some of them took on more central roles in gaming practices over time. Other students, however, did not attempt to directly participate in gaming sites or were not successful in their attempts. These findings are discussed in regard to pedagogical design, including game selection and supporting learner analyses of gaming discourses, as well as avenues for future research examining socialization in classrooms and gaming spaces.
The impact of increased temperatures on germination patterns of semi-aquatic plants
Authors: Dessent Jade , Lawler Susan , Nielsen Daryl 
Published: October 2019

AbstractFuture climate change predictions indicate that there will be an increase in ambient air temperature. Increases in ambient air temperature will result in a corresponding increase in soil temperature. The consequences of further increases in soil temperature will potentially be detrimental for the soil seed bank of plants in terms of length of dormancy and viability of seeds. This experiment investigated the effect of different exposure temperatures and duration of exposure on the germination of semi-aquatic plant species. Seeds of four species (Alternanthera denticulata, Juncus usitatus, Persicaria lapathifolia and Persicaria prostrata) were exposed to temperatures ranging from 25 to 100°C for durations between 1 and 14 days, before being germinated in an incubator for 6 weeks. Germination occurred in all four species after exposure to temperatures ranging from 25 to 60°C. These temperatures appeared to promote germination as the temperature and duration of exposure increased. However, in P. lapathifolia and P. prostrata, the number of seeds germinating declined when exposed to 70°C and there was no germination for temperatures exceeding this. In contrast, A. denticulata and J. usitatus only began to decline when exposed to 80°C, with no germination at higher temperatures. These results suggest that soil temperatures exceeding potential threshold temperatures of 70 and 80°C will result in a decline in the number of seeds germinating and may potentially see a change in species distributions. As such soil temperatures are already being experienced throughout Australia, some species may already be close to their thermal threshold.
A longitudinal description of incompetent to stand trial admissions to a state hospital
Authors: McDermott Barbara E. , Warburton Katherine , Auletta-Young Chloe 
Published: October 2019

Objective.Evidence is clear that the nation is experiencing an increasing number of incompetent to stand trial (IST) admissions to state hospitals. As a result, defendants in need of treatment can wait in jail for weeks for admission for restoration. This study was conducted to better understand this growing population and to inform hospital administration about the characteristics of IST admissions.Methods.The study was conducted at the Department of State Hospitals (DSH) facility in Napa (DSH-Napa), a 1200-bed primarily forensic inpatient psychiatric facility located in northern California. The records of patients found IST and admitted to DSH-Napa for restoration of competence between the dates of 1/1/2009 and 12/31/2016 were eligible for inclusion in the study.Results.There were a total of 3158 unduplicated IST admissions available during the specified time period. Our data indicate that the number of admissions with more than 15 prior arrests increased significantly, from 17.7% in 2009 to 46.4% in 2016. In contrast, the percent of patients reporting prior inpatient psychiatric hospitalization evidenced a consistent decrease over time from over 76% in 2009 to less than 50% in 2016.Conclusion.Our data add to the body of literature on the potential causes of the nationwide increase in competency referrals. The literature is clear that jails and prisons are now the primary provider of the nation’s mental health care. Our data suggest that another system has assumed this role: state hospitals and other providers charged with restoring individuals to competence.