bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of dry and wet electroencephalography for the assessment of cognitive evoked potentials and sensor-level connectivity
Authors: Ehrhardt Nina M. , Niehoff Clara , Oßwald Anna-Christina , Antonenko Daria , Lucchese Guglielmo , Fleischmann Robert 
Published: November 2024

BackgroundMultipin dry electrodes (dry EEG) provide faster and more convenient application than wet EEG, enabling extensive data collection. This study aims to compare task-related time-frequency representations and resting-state connectivity between wet and dry EEG methods to establish a foundation for using dry EEG in investigations of brain activity in neuropsychiatric disorders.MethodsIn this counterbalanced cross-over study, we acquired wet and dry EEG in 33 healthy participants [n = 22 females, mean age (SD) = 24.3 (± 3.4) years] during resting-state and an auditory oddball paradigm. We computed mismatch negativity (MMN), theta power in task EEG, and connectivity measures from resting-state EEG using phase lag index (PLI) and minimum spanning tree (MST). Agreement between wet and dry EEG was assessed using Bland–Altman bias.ResultsMMN was detectable with both systems in time and frequency domains, but dry EEG underestimated MMN mean amplitude, peak latency, and theta power compared to wet EEG. Resting-state connectivity was reliably estimated with dry EEG using MST diameter in all except the very low frequencies (0.5–4 Hz). PLI showed larger differences between wet and dry EEG in all frequencies except theta.ConclusionDry EEG reliably detected MMN and resting-state connectivity despite a lower signal-to-noise ratio. This study provides the methodological basis for using dry EEG in studies investigating the neural processes underlying psychiatric and neurological conditions.
Evaluation of Nurses’ attitudes, behaviors, and barriers toward pressure ulcer prevention in neonatal and pediatric intensive care units
Authors: Mostafa Osama Elshahat , Zakari Nazik M. A. , Al Salem Marwa 
Published: November 2024

IntroductionPressure ulcers are a significant concern in pediatric intensive care units, with prevalence rates ranging from 0.8% to 27%. They pose serious physical and psychological challenges, particularly in neonatal and pediatric intensive care units (NICU and PICU). This study explores nursing strategies, attitudes, and barriers toward pressure ulcer prevention in NICU and PICU settings.MethodsUsing a descriptive study design, data were collected from 80 nurses working in NICU and PICU through validated questionnaires, including a demographic profile and a pressure ulcer survey. Descriptive statistics were employed to calculate mean scores and percentages, while inferential statistics assessed associations between variables.ResultsThe study revealed specific nursing strategies, along with significant barriers and attitudes toward pressure ulcer prevention in NICU and PICU. The total attitude mean score was 3.57, with the highest positive response (mean = 4.29) for “most pressure sores can be avoided”, and the highest negative response (mean = 3.86) for “pressure sore prevention is a low priority for me”. Among participants, 72.5% conducted risk assessments on all patients, 60% had written prevention care plans, and 76.3% implemented preventive strategies. Barriers such as staff shortages and time constraints were reported by 76.2% of nurses. Multivariate analysis indicated that nurses with more than 10 years of qualification (OR = 3.67) and permanent staff with over 10 years of employment (OR = 4.31) were significantly more likely to engage in preventive practices. The use of a pressure ulcer grading tool (OR = 2.49, P &lt; 0.05) and participation in formal training (OR = 3.14, P &lt; 0.05) were also positively associated with preventive practices.DiscussionThese findings underscore the importance of structured assessment tools, ongoing education, and the need to foster positive attitudes among nurses to effectively reduce pressure ulcer prevalence and enhance patient outcomes in NICU and PICU settings.
Concurrent chemoradiotherapy with S-1 versus platinum in the treatment of locoregionally advanced nasopharyngeal carcinoma: a multicenter, retrospective, propensity score-matched analysis
Authors: Bian Chenbin , Zheng Zhuangzhuang , Su Jing , Chang Sitong , Yu Huiyuan , Bao Jindian , Zhao Qin , Jiang Xin 
Published: November 2024

ObjectivesLiterature data are scarce on concurrent chemoradiotherapy (CCRT) with S-1 for locally advanced nasopharyngeal carcinoma (LANPC) treatment. This study compared the efficacy and safety of the S-1 versus platinum-based CCRT in LANPC treatment. Methods: This study enrolled 547 patients newly diagnosed with LANPC who underwent CCRT with S-1 or platinum at three institutions. Propensity score matching in a 1:1 ratio balancing baseline features was performed. Survival and adverse effects were compared between groups.ResultsOf 160 patients in the cohort, 100 eligible were propensity score matched. Matched dataset analyses showed a higher 5-year overall survival rate (87.1% vs. 84.7%, P = 0.833), progression-free survival (79.6% vs. 75.5%, P = 0.669), locoregional recurrence-free survival (87.0% vs. 84.7%, P = 0.518), and distant metastasis-free survival (84.8% vs. 83.0%, P = 0.780) in the S-1 group than in the platinum-based CCRT group, although not statistically significant. Objective response rate (98.0% vs. 88.0%, P = 0.117) was significantly higher in the S-1 than in the platinum-based regimen, although it was not statistically reflected. Compared with platinum-based, those undergoing S-1-based chemotherapy demonstrated a higher incidence of grade 3 mucositis (20.0% vs. 2.0%, P = 0.016) in the S-1 group and a lower incidence of leukopenia (44.0% vs. 68.0%, P = 0.033), neutropenia (28.0% vs. 52.0%, P = 0.032), anemia (22.0% vs. 44.0%, P = 0.040), nephrotoxicity (4.0% vs. 20.0%, P = 0.028), and nausea/vomiting (30.0% vs. 56.0%, P = 0.019).ConclusionThe results suggest that S-1 can be used as a concurrent chemotherapy regimen during radiotherapy for patients with LANPC, since it presents a noninferior survival benefit compared with platinum and shows tolerable adverse effects.
Valorizing sardine scales: a circular approach to sustainable collagen for cosmetics and nutrition applications
Authors: Santos Filipe Marcia , André Rebeca , Ferreira Marco , Diaz-Lanza Ana María , André Vânia , Alves Marta M. , Pacheco Rita , Rijo Patrícia 
Published: November 2024

Background and ObjectiveIn recent years, the consumption of fish products has led to a worrying trend where approximately two-thirds of the total amount of fish is discarded as waste. At the same time, scientific interest in exploring natural collagen sources for cosmetics and dietary supplements has increased. This study explores the potential of valorizing sardine scales (Sardina pilchardus), a by-product of the canning industry, through the extraction of collagen for potential use in dermocosmetic formulations and food supplements.MethodsCollagen from sardine scales was obtained though acid and enzymatic extraction. The collagen extracts were characterized by UV-Vis, FTIR spectroscopy, SDS-PAGE, powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM). The collagen was hydrolysed with papain to small peptides. Subsequently, the biological activities of acid-soluble collagen as well as the collagen peptides in terms of antioxidant and antimicrobial activity were evaluated. Furthermore, the capacity of collagen peptides to permeate the intestinal barrier, simulated with caco-2 cells, was evaluated.ResultsPurified collagen extracts were obtained from sardine scales, with enzymatic extraction method having a yield three times higher than the acid method. The SDS-PAGE analysis confirmed the extraction of type I collagen as well as its hydrolysis into small fragments (25–12 kDa). In terms of biological activities, collagen and collagen peptides have not demonstrated antimicrobial activity. However, regarding antioxidant activity, collagen peptides showed three times more capacity compared to non-hydrolyzed collagen. Meanwhile, in 6 h, about 6.37% of collagen peptides could permeate the intestinal barrier.ConclusionThis work represents a continuous effort to advance our understanding and utilization of Portuguese marine waste resources, with focus on the valorization of sardine co-products for the development of food supplement or cosmetic formulations, contributing to the sustainable evolution of the circular blue economy.
Analysis of tirzepatide in the US FDA adverse event reporting system (FAERS): a focus on overall patient population and sex-specific subgroups
Authors: Ou Yingyong , Cui Zhiwei , Lou Siyu , Zhu Chengyu , Chen Junyou , Zhou Linmei , Zhao Ruizhen , Wang Li , Zou Fan 
Published: November 2024

ObjectiveTirzepatide, a novel GIP and GLP1 agonist, has been extensively examined in clinical trials. However, specific data on its adverse drug events (ADEs) remain limited. This study aims to comprehensively assess real-world ADEs associated with tirzepatide by mining data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database.MethodsADE reports from the FAERS database were retrieved for the second quarter of 2022 through the first quarter of 2024. Significant associations between ADEs and tirzepatide were evaluated using proportional disproportionality analyses, including the Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-item Gamma Poisson Shrinkage (MGPS).ResultsA total of 37,827 ADE reports associated with tirzepatide were identified, with 100 significantly disproportionate preferred terms (PTs) recognized by all four algorithms. The top five PTs with the highest reporting rates were incorrect dose administered, injection site pain, off-label use, nausea, and injection site hemorrhage. Additionally, unexpected signals such as starvation ketoacidosis were identified. The median time to onset for all ADEs was 23 days. Furthermore, sex-specific high-intensity signals were found, with males primarily experiencing gastrointestinal disorders and females experiencing general disorders and administration site conditions.ConclusionThis study provides valuable insights into the occurrence of ADEs following tirzepatide administration, potentially supporting clinical monitoring and risk identification efforts.
Characterization of the craniofacial abnormalities of the homozygous G608G progeria mouse model
Authors: Beeram Indeevar , Cubria Maria Belen , Kamalapathy Pramod , Yeritsyan Diana , Dubose Amanda J. , Razavi Ahmad Hedayatzadeh , Nafisi Nazanin , Erdos Michael R. , Snyder Brian D. , Cabral Wayne A. , Collins Francis S. , Nazarian Ara 
Published: November 2024

IntroductionHutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by premature aging, impacting multiple organ systems, including cardiovascular, musculoskeletal, and integumentary. Significant abnormalities in a transgenic mouse model (homozygous G608G mutation), specifically targeting the development of skull and facial bone indices through high-resolution CT scanning and cephalometric analysis.MethodsKey measurements include bone thickness, skull volume, and cranial suture integrity. Bone volume increased significantly in HGPS mice by 8 months of age compared to wildtype mice.ResultsCortical thickness showed a trend toward increased values in HGPS mice. Cranial metrics revealed distinct differences.DiscussionHGPS mice exhibited smaller internasal width, interzygomatic distance, and palatine length compared to WT mice over time.
Groundcover improves nutrition and growth of citrus trees and reduces water runoff, soil erosion and nutrient loss on sloping farmland
Authors: Liu Rui , Zhang Yuting , Wang Zhichao , Zhang Xueliang , Xu Wenjing , Zhang Jianwei , Zhang Yueqiang , Hu Bin , Shi Xiaojun , Rennenberg Heinz 
Published: November 2024

IntroductionGroundcover management plays a crucial role in improving water retention and soil nutrition in orchard systems, thereby preventing environmental constrains by non-point source pollution. However, effectiveness of groundcover management in citrus orchards developed on sloping farmland with eroded purple soil has not been studied in detail. In particular, information on the soil nutrient losses, e.g., nitrogen (N) and phosphorus (P), through interflow and its effects on growth and nutrition of citrus plants has not been reported.MethodsThe present study evaluated the effects of different cover crops, i.e., Lolium perenne L. (Lolium), Vicia villosa Roth (Vicia) and Orychophragmus violaceus (Ory), on nutrition and growth of citrus trees as well as water, soil and nutrient retention in an orchard developed in sloping farmland during two consecutive years.Results and discussionThe results show that the groundcover species Lolium and Vicia mediated nursing effects on nutrition and growth of citrus trees. These nursing effects included enhanced foliar levels of carbon(C), N and P as well as increased tree height, stem diameter, and crown width. Groundcover management generally reduced the annual surface runoff, interflow, soil loss, total N loss and total P loss. Among the cover crop species studied, Lolium and Vicia were overall more efficient than Ory in this context. Lolium reduced the average annual total loss of N and P by 42.53% and 49.23%, respectively, compared with clean tillage. The estimated annual reduction potentials of soil, N and P losses in Southwestern China were 16.3, 3.4 and 8.5 million tons yr-1, respectively. Obviously, Lolium and Vicia provide highly beneficial ground coverage on sloping farmland and, thus, can be used for future sustainable development of citrus orchards.
Expectations regarding school decreases emotional distress among college students in Western China: the buffering role of physical exercises
Authors: Su Di , Huang Lina , Zou Helin , Zhang Lulu , Feng Yi 
Published: November 2024

BackgroundCollege students in Western China face unique economic, cultural, and educational environments, yet limited studies have specifically investigated the factors or interventions concerning emotional distress within this population.AimThis study aimed to explore whether school belongingness mediates the relationship between expectations regarding school and emotional distress among college students in Western China, and whether physical exercise moderates this mediation.MethodsEmploying a cross-sectional design, 1,063 college students in Xinjiang, China were recruited for this study. A self-administered electronic questionnaire assessed expectations regarding school, school belongingness, physical exercise, anxiety, and depression. Structural equation modeling was utilized to analyze mediating and moderating effects.ResultsExpectations regarding school was negatively associated with emotional distress. School exclusion and school acceptance fully mediated the effect of expectations regarding school on emotional distress. Physical exercise moderated the mediating effect of school exclusion, but not that of school acceptance.ConclusionExpectations regarding school and school belongingness, particularly the exclusion component, emerge as pivotal factors influencing emotional distress among college students in Western China. Furthermore, physical exercise presents itself as a promising targeted intervention for alleviating emotional distress within this demographic.
Psychology of nerve injury, repair, and recovery: a systematic review
Authors: Adu Yaw , Cox Cameron T. , Hernandez Evan J. , Zhu Christina , Trevino Zachary , MacKay Brendan J. 
Published: November 2024

BackgroundPeripheral nerve injuries (PNIs) are associated with significant physical and psychological challenges, impacting both functional recovery and quality of life. Despite the physical focus of traditional treatments, psychological factors play a crucial role in the outcomes of PNI repair and recovery.ObjectivesThis systematic review aims to evaluate the impact of psychological and social factors on the repair and recovery of peripheral nerve injuries.MethodsA comprehensive literature search was conducted in PubMed/Medline, EMBASE, and Cochrane databases, covering studies from January 1985 to December 2022. A total of 36,190 records were identified, and after screening with Rayyan AI and applying inclusion criteria, 111 articles were selected for review.ResultsThe review highlights that pre-existing psychological conditions, as well as psychological responses to the injury and treatment, significantly influence recovery outcomes in PNI patients. Psychological interventions, when integrated into standard care, may improve functional recovery and quality of life.ConclusionsPsychosocial factors are critical in the management of PNIs and should be incorporated into treatment algorithms to enhance patient outcomes. Future research should focus on developing and integrating psychological support strategies in PNI treatment protocols.
Towards an emerging role for anticoagulants in cancer therapy: a systematic review and meta-analysis
Authors: Al-Azzawi Huda Moutaz Asmael , Hamza Syed Ameer , Paolini Rita , Arshad Fizza , Patini Romeo , O’Reilly Lorraine , McCullough Michael , Celentano Antonio 
Published: November 2024

BackgroundAnticoagulants, renowned for their role in preventing blood clot formation, have captivated researchers’ attention for the exploitation of their potential to inhibit cancer in pre-clinical models.ObjectivesTo undertake a systematic review and meta-analysis of the effects of anticoagulants in murine cancer research models. Further, to present a reference tool for anticoagulant therapeutic modalities relating to future animal pre-clinical models of cancer and their translation into the clinic.MethodsFour databases were utilized including Medline (Ovid), Embase (Ovid), Web of science, and Scopus databases. We included studies relating to any cancer conducted in murine models that assessed the effect of traditional anticoagulants (heparin and its derivatives and warfarin) and newer oral anticoagulants on cancer.ResultsA total of 6,158 articles were identified in an initial multi-database search. A total of 157 records were finally included for data extraction. Studies on heparin species and warfarin demonstrated statistically significant results in favour of tumour growth and metastasis inhibition.ConclusionOur findings constitute a valuable reference guide for the application of anticoagulants in cancer research and explore the promising utilization of non-anticoagulants heparin in preclinical cancer research.Systematic Review RegistrationPROSPERO [CRD42024555603].
Duration of insomnia and success expectancy predict treatment outcome of iCBT for insomnia
Authors: Pchelina Polina , Poluektov Mikhail 
Published: November 2024

IntroductionIdentifying prognostic factors of treatment outcome may assist in customizing an intervention to a patient's needs. Hence, we conducted a secondary analysis of data from a randomized controlled trial to investigate the effectiveness of an internet-based cognitive behavioral therapy for insomnia (iCBT-I) to find patient characteristics that may predict the change of insomnia severity after treatment.Materials and methodsIn this exploratory analysis involving 94 chronic insomnia patients, we examined the predictive value of several self-reported measures, medical history, and sociodemographic variables to psychological distress with separate linear regression models. The main outcome was the Insomnia Severity Index score improvement from pre- to post-treatmentResultsThe study found that duration of insomnia, b (SE) = −0.02 (0.01), p = 0.01, and attitudes about the expected treatment success, b (SE) = 0.80 (0.27), p = 0.004, were predictors of a better outcome. Moreover, a better outcome was associated with a lower level of the following traits: attention seeking, b (SE) = −1.06 (0.51), p = 0.04; grandiosity, b (SE) = −1.50 (0.57), p = 0.01; distractibility, b (SE) = −1.57 (0.75), p = 0.04; and rigid perfectionism, b (SE) = −1.32 (0.65), p = 0.05.ConclusionOur results suggest that iCBT-I might be particularly beneficial for patients with higher expectations from the therapy and those who have a shorter duration of insomnia. Some pronounced personality traits, such as attention seeking, grandiosity, distractibility, and rigid perfectionism, may predict worse outcomes. However, because this was a post-hoc analysis, our results must be considered exploratory and verified in further studies.Clinical trial registrationhttps://clinicaltrials.gov/study/NCT04300218?cond=NCT04300218&amp;rank=1, Identifier NCT04300218.
Valorization of coconut (Cocos nucifera L.) testa as a biocolourant
Authors: Ramesh S. V. , Pandiselvam R. , Shameena Beegum P. P. , Shil Sandip , Sugatha P. , Sharanya K. , Manikantan M. R. , Gopal Murali , Hebbar K. B. , Uchoi Anok , Das Alpana , Bhat Ravi , Gowda B. Hanumanthe , Kumar Prabhat 
Published: November 2024

IntroductionCoconut testa, a by-product of the coconut processing industry, is currently underutilised. This study aimed to extract a coconut testa-based food colourant using various organic solvents and physical methods, and to utilise this colourant in food product preparation.MethodsDifferent organic solvents, along with various time and temperature combinations, were employed for colourant extraction using both a laboratory-scale water bath and ultrasonication. The colour coordinate values (CIELab) of the testa-derived colourants were measured, and the colourants were screened for various phytochemicals. The in vitro antioxidant potential of the testa colourant was assessed by quantifying total phenolics, and the phytochemical composition, including monomeric anthocyanins, was evaluated.ResultsThe study determined the optimal combinations of organic solvents, temperature and time to obtain extracts with maximum antioxidant activity and total phenolic content (TPC). Acidified ethanol-based extracts of testa colourants yielded highest polyphenol content (154.39 ± 2.63 mg GAE/g) and flavonoids content (53.65 ± 0.62 mg QE/g). Similarly, ethanol-based extractants of coconut testa produced high anthocyanin content [823.02 ± 1.81 mg Cy-3-glc equivalents (C3GE)/100 g]. Acidified (0.3 M HCl) solvents at relatively high temperature and time combinations exhibited high antioxidant potential of testa colourant, as measured by CUPRAC, FRAP, and DPPH assays. Following the foam mat drying process of the colourant, a mature coconut water-based jelly was prepared by incorporating the testa colourant extracted with acidified ethanol.DiscussionThis study highlights the biochemical and antioxidant potential of the food colorant derived from coconut testa and explores its suitability for functional food applications. Therefore, coconut testa extract serves a dual purpose: it enhances the aesthetic appeal of food as a colourant and provides significant health-promoting properties due to its high anthocyanin content. Insights from this study could help in promoting the valorization of one of the beneficial by products of coconut industry.