bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Long-Term Prophylactic Treatment With Subcutaneous C1 Esterase Inhibitor in a Patient With Hereditary Angioedema
Authors: Hahn Janina , Nordmann-Kleiner Melanie , Trainotti Susanne , Hoffmann Thomas K. , Greve Jens 
Published: June 2019

Background: Hereditary angioedema (HAE) patients suffer from recurrent swellings. Current standard therapy consists of C1 esterase inhibitor (C1-INH) and bradykinin receptor B2 antagonists. Severe courses require prophylactic treatment. For such patients, it has been demonstrated that the intravenous (IV) administration of C1-INH [C1-INH(IV)] is safe and effective. A new prophylactic option is subcutaneous (SC) treatment with C1-INH. Methods and Case: We present the case of an HAE patient placed on prophylactic C1-INH(IV) therapy due to frequent attacks when managed with on-demand therapy. An implanted port allowed the periodical and safe application of medication until the device was explanted due to an infection. Due to the poor venous access, repeated IV application failed. Therefore, we began a SC treatment with 1500 IU C1-INH [C1-INH(SC)] as long-term prophylaxis and analyzed the clinical course over 16 months. Results: Under the SC prophylaxis, the number of attacks were reduced to 1/month in comparison to 4.33/month with no prophylactic treatment and 1.83/month with C1-INH(IV). No severe attacks and no attack within the upper airway occurred over the 16 months of C1-INH(SC) treatment. As a result, quality of life improved, as measured by the Angioedema quality of life questionaire (AE-QoL). Conclusion: Self-administered SC prophylactic use of C1-INH over a period of 16 months seems to be a well tolerated and efficient. The patient’s quality of life improved, and by learning self-application, the patient gained independence.
Predicting outcome in traumatic brain injury using a new outcome assessment scale – The Lagos Brain Disability Examination Scale (LABDES)
Authors: Idowu Olufemi Emmanuel , Oshinaike Olajumoke , Ogun Shamsideen Abayomi , Arabambi Babawale , Orungbeja Toluwani Opeyemi , Malomo Oluwabusayomi Oghenerume , Aisudo Charles Kolawole , Oyeleye Olarinmoye Oluwole 
Published: June 2019

Introduction Traumatic brain injury management is a leading cause of disability and death in young adults. Our objective was to develop a new multidomain, comprehensive, sensitive, objective and easily reproducible outcome scale with high predictive accuracy to assess patients with traumatic brain injury. The developed outcome assessment tool, the Lagos Brain Disability Examination Scale was then tested for any association of outcome predictability with patients’ admission modified Marshall, Rotterdam and Helsinki computerized tomographic scores. Methods A prospective cohort study was carried out of patients aged 16 years and above who sustained traumatic brain injury. All recruited patients had their biodata and derived cranial computerized tomographic scores documented using the modified Marshall, Rotterdam and Helsinki computerized tomographic scale on a pro forma. Outcomes were assessed at eight weeks after traumatic brain injury with the Lagos Brain Disability Examination Scale. Statistical significance was judged at p < 0.05 level. Results Forty-one patients were included (31 males; mean age 38.6 years, median 38 years, range 16–83 years). The Helsinki score gave a better prognostic predictability compared to the other computerized tomographic scoring systems. Twenty-one (51.2%) patients had good recovery according to the Lagos Brain Disability Examination Scale grade. Conclusions Patients’ outcome prediction on the Lagos Brain Disability Examination Scale is best using the initial Helsinki computerized tomographic scoring system. The Lagos Brain Disability Examination Scale appears to be a comprehensive and valid outcome measure to use in patients with traumatic brain injury.
The Use of Closure Devices for Aortic Stent-Graft Insertion: Outcomes Following a Paradigm Shift to Percutaneous Access in a Tertiary Vascular Center
Authors: White Alan D. , Hazar Can , Jarosz David , Walker Paul , Shaw David , Tingerides Costa 
Published: June 2019

Background: This retrospective case series aims to evaluate the efficacy of the Perclose ProGlide system for postoperative hemostasis following aortic stent-graft insertion. Material and Methods: A prospectively maintained database of patients with a minimum follow-up of 12 months following percutaneous aortic procedures was interrogated. Preprocedural computed tomography (CT) scans were reviewed to assess existing stenosis in the common femoral artery (CFA). Arteries with an estimated stenosis of greater than 25% on visual inspection underwent quantification using multiplanar and curved planar reformation. The preoperative and 1-year follow-up CTs of these patients were assessed for change in stenosis. Analysis was performed by 2 independent reviewers, with senior authors reviewing any discrepancies. Results: One hundred forty-two endovascular aortic aneurysm repairs (EVARs) were performed. The ProGlide system was used in 235 arteries, yielding a high success rate in obtaining postprocedural hemostasis (94%). There were 13 postprocedural access-related complications, including 5 patients requiring surgical closure due to inadequate seal. Two patients required thrombectomy due to distal embolization. One patient required CFA endarterectomy at 6 months for the treatment of preexisting short distance claudication. Vessel analysis was performed in 31 arteries. Mean preoperative stenosis was 32% (range: 20%-57%). Mean postoperative stenosis was 32% (21%-57%). No significant change in degree of stenosis was detected (defined as a 5% change). Conclusions: The ProGlide system yielded a high success rate in obtaining postoperative hemostasis with low rate of conversion to surgical closure and low complication rates. There was no evidence of worsening vessel stenosis in arteries with preprocedural stenotic disease. Level of Evidence: Level 4, Case Series.
Alternative Medicine Methods Used for Weight Loss and Diabetes Control by Overweight and Obese Hispanic Immigrant Women
Authors: Lindberg Nangel M. , Vega-López Sonia , Arias-Gastelum Mayra , Stevens Victor J. 
Published: June 2019

Introduction: Middle-aged Hispanic women have the highest prevalence of overweight and lifetime risk for diabetes of all gender/racial groups. This study examines use of alternative medicine for weight loss and diabetes management among overweight and obese Mexican American women with or at risk for diabetes. Method: As part of a diabetes risk-reduction intervention targeting overweight and obese Hispanic women at a federally qualified health center in Hillsboro, Oregon, we administered a survey of different treatment modalities, including alternative medicine, traditional Mexican medicine, and home remedies to 85 Hispanic women. We also asked participants how often they disclosed their use of alternative methods to their providers. Results: Nearly all participants with diabetes (97%) reported using at least one alternative strategy for diabetes control, with home remedies, commercial weight-loss products, and herbal teas being the most endorsed. Most participants with diabetes and half of those without diabetes reported never telling their provider. Conclusion: This group of women reported a high prevalence of use of alternative methods for weight control and diabetes management. Yet most participants with diabetes never reported this use to a health care provider. To ensure patient safety, providers treating Hispanic women need to probe for complementary and alternative medicine practices.
Aspirin for primary prevention of stroke in individuals without cardiovascular disease—A meta-analysis
Authors: Judge Conor , Ruttledge Sarah , Murphy Robert , Loughlin Elaine , Gorey Sarah , Costello Maria , Nolan Aoife , Ferguson John , Halloran Martin O , O'Canavan Michelle , O'Donnell Martin J 
Published: June 2019

Background The benefits of aspirin for primary prevention of stroke are uncertain. Methods We performed a cumulative meta-analysis of trials investigating aspirin for primary prevention of cardiovascular disease with a focus on stroke. We assessed the effects of aspirin on non-fatal stroke, hemorrhagic stroke, non-fatal myocardial infarction, all-cause mortality, cardiovascular mortality, major gastrointestinal bleeding, and an analysis of net clinical effect, in populations without a history of clinical or subclinical cardiovascular disease. Summary of review results Among 11 trials (157,054 participants), aspirin was not associated with a statistically significant reduction in non-fatal stroke (odds ratio, 0.94; 95% CI, 0.85 to 1.04) but was associated with an increased risk of hemorrhagic stroke (odds ratio, 1.29; 95% CI, 1.06 to 1.56). Aspirin was not associated with a statistically significant reduction in all-cause mortality (odds ratio, 0.97; 95% CI, 0.92 to 1.03) or cardiovascular mortality (odds ratio, 0.94; 95% CI, 0.85 to 1.03). Aspirin was associated with a reduction in non-fatal myocardial infarction (odds ratio, 0.80; 95% CI, 0.69 to 0.94) and an increased risk of major gastrointestinal bleeding (odds ratio, 1.83; 95% CI, 1.43 to 2.35). Using equal weighting for non-fatal events and major bleeding, we observed no net clinical benefit with aspirin use for primary prevention. Conclusion Our meta-analysis reports no benefit of aspirin for primary stroke prevention.
Modular bipolar hemiarthroplasty for fracture neck of femur using contemporary cementing technique: Long-term results of a single design
Authors: Mak Yik-Fung , Li Hok-Yin-Alwin , Lee Qunn-Jid , Wong Yiu-Chung 
Published: June 2019

Introduction: The use of bipolar prosthesis in the management of displaced fracture neck of femur has remained controversial. There has been a lack of long-term studies in its results and survivorship, especially in acetabular erosion. Methods: We retrospectively reviewed 108 single design bipolar hemiarthroplasties (105 patients) performed in a single centre between 1999 and 2008, with a mean follow-up of 7.4 years (range: 2.2–18.3 years). General indications of surgery include displaced fracture with age less than 75, narrow femoral canals not permitting the use of a monoblock implant or as salvage procedure for failed internal fixation. Results: Six hips (5%) required further surgery – two patients had debridement for infection and four patients required revision to total hip arthroplasty (THA) due to infection or aseptic loosening. There was no dislocation. No revision was required for acetabulum erosion. Kaplan–Meier analysis showed a 15-year survival free of revision due to any reason to be 93.1% and due to aseptic loosening to be 97.1%. Discussion: Our centre has shown excellent clinical results and low revision rate with the cemented bipolar system. In the context of displaced fracture neck of femur, the long-term results can be compared with THA which is associated with higher perioperative morbidity.
The effect of erythropoietin on rat rotator cuff repair model: An experimental study
Authors: Oztermeli Ahmet , Karaca Sinan , Yucel Istemi , Midi Ahmet , Sen Elif Itir , Ozturk Burak Yagmur 
Published: June 2019

Objectives: The aim of this study was to determine whether erythropoietin (EPO) can enhance rotator cuff healing in rats as measured by histological analysis and biomechanical testing. Methods: A total of 72 rats were included in this study. In the control group ( n = 24), repair was performed without EPO injection. In the local group ( n = 24) EPO was injected in the repair site. In the systemic group ( n = 24) EPO was administered as an intraperitoneal injection every day for 10 days after repair. Rats were euthanized on day 10 ( n = 12 from each group) and day 28 ( n = 12 from each group). Histopathological ( n = 6) and biomechanical examinations ( n = 6) were done. Results: Biomechanical results reveal that the maximum load to failure values of the early control group were statistically lower than those of the early systemic group ( p = 0.006). Comparing the the total Bonar values histopathologically reveal that the early systemic group was statistically higher than those of the early local group ( p = 0.043). The late control group was statistically higher than those of the late local group ( p = 0.003) and the late systemic group ( p = 0.034). The late systemic group was statistically higher than those of the late local group ( p = 0.003). Conclusions: EPO application had a positive effect biomechanically in the early euthanized group and histopathologically in the late euthanized group.
Lateral Compartment Contact Pressures Do Not Increase After Lateral Extra-articular Tenodesis and Subsequent Subtotal Meniscectomy
Authors: Shimakawa Tomoyuki , Burkhart Timothy A. , Dunning Cynthia E. , Degen Ryan M. , Getgood Alan M. 
Published: June 2019

Background: Modified Lemaire lateral extra-articular tenodesis (LET) has been proposed as a method of addressing persistent anterolateral rotatory laxity after anterior cruciate ligament (ACL) reconstruction (ACLR). However, concerns remain regarding the potential for increasing lateral compartment contact pressures. Purpose: To investigate changes in tibiofemoral joint contact pressures after isolated ACLR and combined ACLR plus LET with varying states of a lateral meniscal injury. Study Design: Controlled laboratory study. Methods: Eight fresh-frozen cadaveric knee specimens (mean age, 60.0 ± 3.4 years) were utilized for this study, with specimens potted and loaded on a materials testing machine. A pressure sensor was inserted into the lateral compartment of the tibiofemoral joint, and specimens were loaded at 0°, 30°, 60°, and 90° of flexion in the following states: (1) baseline (ACL- and anterolateral ligament–deficient), (2) ACLR, (3) ACLR with LET, (4) partial meniscectomy (removal of 50% of the posterior third of the lateral meniscus), (5) subtotal meniscectomy (removal of 100% of the posterior third of the lateral meniscus), and (6) LET release (LETR). Mean contact pressure, peak pressure, and center of pressure were analyzed using 1-way repeated-measures analysis of variance. Results: Across all flexion angles, there was no statistically significant increase in the mean contact pressure or peak pressure after ACLR plus LET with and without lateral meniscectomy compared with isolated ACLR. There was a significant reduction in the mean contact pressure, from baseline, after subtotal meniscectomy (69.72% ± 19.27% baseline; P = .04) and LETR (65.81% ± 13.40% baseline; P = .003) at 0° and after the addition of LET to ACLR at 30° (61.20% ± 23.08% baseline; P = .031). The center of pressure was observed to be more anterior after partial (0°, 30°) and subtotal (0°, 60°) meniscectomy and LETR (0°, 30°, 60°). Conclusion: Under the loading conditions of this study, LET did not significantly alter lateral compartment contact pressures when performed in conjunction with ACLR in the setting of an intact or posterior horn–deficient lateral meniscus. Clinical Relevance: This study should provide surgeons with the confidence that it is safe to perform LET in this manner in conjunction with ACLR without altering lateral compartment pressures, regardless of the status of the lateral meniscus.
Evaluation of Counseling Practices and Patient’s Satisfaction Offered by Pharmacists for Diabetics Attending Outpatient Pharmacies in Al Ahsa
Authors: Emeka Promise M , AlMunjem Manea Fares , Rasool Sahibzada Tasleem , Kamil Noor 
Published: June 2019

Introduction: Patient counseling can be helpful in improving the outcome of disease management, particularly chronic diseases such as diabetes mellitus, which is common in Saudi Arabia. The present study looks to investigate the levels of counseling and satisfaction among patients attending diabetic clinics in outpatient hospital pharmacy in Al Ahsa, Saudi Arabia. Method: This is a cross-sectional investigation, carried out by using interview-structured questionnaire, targeting diabetes mellitus patients with or without comorbid states. The questionnaire was divided into 3 parts comprising of demographics, counseling types given while collecting prescription, and satisfaction rating of services provided. Result: More males than females participated; most of whom were college graduates older than 51 years. Sixty-three percent of the entire participants are type 1 diabetic patients, while 37% are type 2 diabetes mellitus patients. Coexistence of hypercholesterolemia was higher among type 1 diabetes patients with 51.9%, while hypertension was more common among type 2 diabetic patients representing 68.2%. Findings also showed that counseling was provided for medication use among type 1 diabetic patients but was deficient in the case of type 2 diabetic patients. Patients received low level of counseling on side effects and healthy lifestyle living. Satisfaction level was only 11.1%, indicating that counseling services might be deficient. Conclusion: This study has revealed poor counseling practices and low satisfaction levels in services provided by outpatient hospital pharmacies to diabetic patients. In the face of increasing prevalence of diabetes and comorbidity, counseling of diabetic patients is critical.
Gestational Diabetes Adversely Affects Pancreatic Islet Architecture and Function in the Male Rat Offspring
Authors: Agarwal Prasoon , Brar Navdeep , Morriseau Taylor S , Kereliuk Stephanie M , Fonseca Mario A , Cole Laura K , Jha Aruni , Xiang Bo , Hunt Kristin L , Seshadri Nivedita , Hatch Grant M , Doucette Christine A , Dolinsky Vernon W 
Published: June 2019

Abstract
Fetal exposure to gestational diabetes mellitus (GDM) and poor postnatal diet are strong risk factors for type 2 diabetes development later in life, but the mechanisms connecting GDM exposure to offspring metabolic health remains unclear. In this study, we aimed to determine how GDM interacts with the postnatal diet to affect islet function in the offspring as well as characterize the gene expression changes in the islets. GDM was induced in female rats using a high-fat, high-sucrose (HFS) diet, and litters from lean or GDM dams were weaned onto a low-fat (LF) or HFS diet. Compared with the lean control offspring, GDM exposure reduced glucose-stimulated insulin secretion in islets isolated from 15-week-old offspring, which was additively worsened when GDM exposure was combined with postnatal HFS diet consumption. In the HFS diet–fed offspring of lean dams, islet size and number increased, an adaptation that was not observed in the HFS diet–fed offspring of GDM dams. Islet gene expression in the offspring of GDM dams was altered in such categories as inflammation (e.g., Il1b, Ccl2), mitochondrial function/oxidative stress resistance (e.g., Atp5f1, Sod2), and ribosomal proteins (e.g., Rps6, Rps14). These results demonstrate that GDM exposure induced marked changes in gene expression in the male young adult rat offspring that cumulatively interact to worsen islet function, whole-body glucose homeostasis, and adaptations to HFS diets.
Synthesis, Adsorption Properties and Stability of Cr-Doped Lithium Ion Sieve in Salt Lake Brine
Authors: Cao Gaifang , Yang Xiyun , Yin Zhoulan , Lei Yuntao , Wang Hao , Li Jishen 
Published: June 2019

Abstract
Li1.6Mn1.6−xCrxO4 was synthesized by hydrothermal reaction followed by acid leaching to form lithium ion sieve. The structure, morphology and composition were examined using X-ray diffraction, SEM and EDS. The influences of Cr doping content and hydrothermal temperature on Li+ adsorption capacity and manganese dissolution ratio were investigated. The result indicates that Cr is incorporated into the spinel structure with cell contraction when x ≤ 0.08. Li1.6Mn1.6−xCrxO4 shows Li+ adsorption capacity of 31.67 mg/g and Mn dissolution ratio of 2.1% when x is 0.016 at 270 °C. After 20 cycles in salt lake brine, the Mn dissolution ratio and Li adsorption capacity is 0.35% and 25.5 mg/g, respectively. The Cr-doped ion-sieve shows improved adsorption capacity, retention and structural stability compared with the undoped lithium ion-sieve. The adsorption process for the Cr-doped ion-sieve follows a pseudo-second-order kinetic model.
Evaluation of a pilot program for task sharing short and long-acting contraceptive methods in Burkina Faso
Authors: Chin-Quee Dawn S. , Ridgeway Kathleen , Onadja Yentéma , Guiella Georges , Bai Guy Martial , Brennan Claire , Page Georgina 
Published: June 2019

Background: The Family Health Directorate of the Ministry of Health (MoH/FHD) and Marie Stopes Burkina Faso (MS BF), with implementing partners, Association Burkinabé pour le Bien-être Familial (ABBEF) and Equilibres & Populations (Equipop) collaborated to conduct a pilot project in Burkina Faso focused on “increasing access to family planning (FP) services through task-sharing short- and long-acting family planning methods to primary care cadres.” Four cadres of providers were trained to provide intrauterine devices (IUDs) and implants, while community health workers (CHWs) were trained to provide pills and subcutaneous injectables. FHI 360 and the Institut Supérieur des Sciences de la Population (ISSP) evaluated the project’s impact on method uptake, client satisfaction, safety, acceptability and the feasibility of task sharing. Methods: The evaluation employed service statistics, client exit interviews (quantitative) and in-depth interviews (qualitative). New FP clients, community representatives, MoH officials, and pilot project-trained FP providers from Dandé and Tougan districts participated in these interviews. Results: Providers, community representatives and government officials all spoke favorably of the pilot project and considered it a boon to women and the communities in which they lived. FP clients were satisfied with their methods and the services they received from their respective providers, and they reported no safety concerns. However, service statistics did not show a clear and steady increase in method uptake for the four methods beyond spikes coinciding with pre-existing free contraceptive weeks. Conclusions: Results of the evaluation were largely positive. These evaluation findings are being used to guide decisions about scale-up.
Modeling of Complex Systems by Means of Partial Algebras
Authors: Bila Jiri , Rodríguez Ricardo Jorge , Novak Martin 
Published: June 2019

Complex systems are very hard to describe by some unified language and calculus. In cases when their nature is very heterogeneous is possible to use with advantage state description. Formalization of operations on the set of states usually leads to partial algebras. The work with partial algebras is rather difficult and unpractical. From this reason some methods approximating partial algebras by some more symmetrical objects are searched for. In this paper there is proposed an approximation of this algebras by free cyclic groups. Then using the combination of Matroid Theory and Ramsey theory of graph the prediction of a possible appearance of emergent situation is executed. Data and knowledge used in the paper for the demonstration of developed method application are from the field of Ecology.
Dos relatórios provinciais à polifonia dos moradores do Quilombo de Santa Tereza do Matupiri-Andirá/AM, Norte do Brasil
Authors: Albuquerque Renan , Ferreira Georgio Ítalo 
Published: June 2019

Foi feito levantamento historiográfico sobre a temática da escravidão negra na Amazônia com direcionamento Ã reflexão sobre o processo de autodeclaração do Quilombo do Matupiri, município de Barreirinha/Amazonas. A metodologia foi instrumentalizada pela técnica do uso de etnografia e coleta de narrativas em campo. Conclui-se que o recente movimento de autodeclaração dos comunitários de Santa Tereza do Matupiri, conceitualmente chamado de etnogênese, fomentou a recriação de novos processos de territorialização da região do rio Andirá, sendo que se afirmar como quilombola fortaleceu laços afetivos e de pertencimento Ã terra, objetivados em festividades e economia na região.