bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adequacy of Pain Control in Patients With Advanced Cancer in Pakistan
Authors: Majeed Muhammad Hassan , Nadeem Ramsha , Khokhar Muhammad Abbas , Qaisar Muhammad Nawaz 
Published: September 2018

Purpose: Pain is highly prevalent in advanced cancer and requires aggressive management. However, pain management in cancer is minimally investigated in Pakistan. This cross-sectional study explores the adequacy of pain management in patients with advanced stage cancer in Pakistan. Method: From January 2017 to May 2017, a cross-sectional study was conducted at Mayo Hospital, Lahore, Pakistan. A total of 218 patients with cancers were interviewed, and 136 patients with pain ≥5 on a Numerical Rating Scale for pain were included in the study. Demographic of patients and clinical characteristics of tumors were also evaluated. Results: Only about one-third of the patients with advanced cancer reported adequate pain management. Chi-square test, χ2 (1, n = 136) = 33.038, P < .05, indicated that pain scores were inversely associated with pain control; inadequate pain control was observed in patients with higher pain score and vice versa. Of the 55.88% of patients who were prescribed morphine, only 6 patients were compliant with treatment recommendations. Most patients were prescribed nonopioid medications and tramadol and codeine, which are weak opioid medications. Conclusion: The rate of undertreatment of cancer pain in Pakistan is alarming. Inadequate clinicians’ training, patients’ and caregivers’ beliefs, lack of availability of opioid medications, and socioeconomic factors are some of the barriers to effective pain control. A multidisciplinary team approach is necessary to follow the World Health Organization pain ladder guidelines for the treatment of cancer pain.
Emerging Challenges of Rural Labour Market: Insights from Indian Villages
Authors: Roy Namrata Singha , Mukhopadhyay Ishita 
Published: September 2018

This article has examined the labour market behaviour of rural India, with the objective to assess the changes taking place in the structure of the workforce and attempts to identify the factors affecting the changes in rural labour supply. In particular, this article tries to address the inconsistency between absolute declines in labour force, particularly rural females at national level, with the micro-level evidences of feminisation in farm work through the estimation of labour supply function. Empirical findings indicate an increasing trend in female participation, particularly aged in rural India. The significant positive association of occupation dummy with male labour supply and negative association with female labour supply, in one way, explains the greater participation of male workers in non-farm work and higher concentration of females in farm activities. Therefore, attention needs to be paid to promote initiatives such as youth entrepreneurship in agriculture to retain youth in farming, encourage innovations in designing appropriate location-specific machineries and tools which are female-friendly, and also organise capacity-building programmes for skill augmentation focusing rural female workers. JEL: J21, J43, J42, J16
Fear extinction learning ability predicts neuropathic pain behaviors and amygdala activity in male rats
Authors: Ji Guangchen , Yakhnitsa Vadim , Kiritoshi Takaki , Presto Peyton , Neugebauer Volker 
Published: September 2018

Background The amygdala plays a key role in fear learning and extinction and has emerged as an important node of emotional-affective aspects of pain and pain modulation. Impaired fear extinction learning, which involves prefrontal cortical control of amygdala processing, has been linked to neuropsychiatric disorders. Here, we tested the hypothesis that fear extinction learning ability can predict the magnitude of neuropathic pain. Results We correlated fear extinction learning in naive adult male rats with sensory and affective behavioral outcome measures (mechanical thresholds, vocalizations, and anxiety- and depression-like behaviors) before and after the induction of the spinal nerve ligation model of neuropathic pain compared to sham controls. Auditory fear conditioning, extinction learning, and extinction retention tests were conducted after baseline testing. All rats showed increased freezing responses after fear conditioning. During extinction training, the majority (75%) of rats showed a decline in freezing level to 50% in 5 min (fear extinction+), whereas 25% of the rats maintained a high freezing level (>50%, fear extinction−). Fear extinction− rats showed decreased open-arm preference in the elevated plus maze, reflecting anxiety-like behavior, but there were no significant differences in sensory thresholds, vocalizations, or depression-like behavior (forced swim test) between fear extinction+ and fear extinction− types. In the neuropathic pain model (four weeks after spinal nerve ligation), fear extinction− rats showed a greater increase in vocalizations and anxiety-like behavior than fear extinction+ rats. Fear extinction− rats, but not fear extinction+ rats, also developed depression-like behavior. Extracellular single unit recordings of amygdala (central nucleus) neurons in behaviorally tested rats (anesthetized with isoflurane) found greater increases in background activity, bursting, and evoked activity in fear extinction− rats than fear extinction+ rats in the spinal nerve ligation model compared to sham controls. Conclusion The data may suggest that fear extinction learning ability predicts the magnitude of neuropathic pain-related affective rather than sensory behaviors, which correlates with differences in amygdala activity changes.
Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling
Authors: Fillebeen Carine , Wilkinson Nicole , Charlebois Edouard , Katsarou Angeliki , Wagner John , Pantopoulos Kostas 
Published: September 2018

Abstract
Systemic iron balance is controlled by hepcidin, a liver hormone that limits iron efflux to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells. Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload. Hjv−/− mice recapitulate phenotypic hallmarks of hemochromatosis but exhibit blunted hepcidin induction following lipopolysaccharide (LPS) administration. We show that Hjv−/− mice fail to mount an appropriate hypoferremic response to acute inflammation caused by LPS, the lipopeptide FSL1, or Escherichia coli infection because residual hepcidin does not suffice to drastically decrease macrophage ferroportin levels. Hfe−/− mice, a model of milder hemochromatosis, exhibit almost wild-type inflammatory hepcidin expression and associated effects, whereas double Hjv−/−Hfe−/− mice phenocopy single Hjv−/− counterparts. In primary murine hepatocytes, Hjv deficiency does not affect interleukin-6 (IL-6)/Stat, and only slightly inhibits BMP2/Smad signaling to hepcidin; however, it severely impairs BMP6/Smad signaling and thereby abolishes synergism with the IL-6/Stat pathway. Inflammatory induction of hepcidin is suppressed in iron-deficient wild-type mice and recovers after the animals are provided overnight access to an iron-rich diet. We conclude that Hjv is required for inflammatory induction of hepcidin and controls the acute hypoferremic response by maintaining a threshold of Bmp6/Smad signaling. Our data highlight Hjv as a potential pharmacological target against anemia of inflammation.
Implementing an Electronic Data Capture System to Improve Clinical Workflow in a Large Academic Radiation Oncology Practice
Authors: Pasalic Dario , Reddy Jay P. , Edwards Timothy , Pan Hubert Y. , Smith Benjamin D. 
Published: September 2018

Purpose To describe the feasibility and benefits of implementing a custom radiation oncology electronic data capture (EDC) system in a large academic radiation oncology practice. Patients and Methods A Web-based point-and-click EDC known as Brocade was internally developed and implemented systemwide in 2016. Brocade captures key data elements, such as stage, histology, and patient and treatment characteristics; links this information to radiation dose data extracted from the record and verify system; and creates clinical notes that are automatically exported to the hospital electronic health record. We report the number of unique radiation episodes captured by Brocade in its first full year of implementation and describe the notes generated, toxicities captured, compliance with staging and quality assurance, and time of day in which documentation occurred with Brocade versus our prior human transcription system. Results A median of 756 radiation episodes per month was captured for a total of 9,283 unique episodes captured in the first full year of implementation. The most common notes were for on-treatment visits (29,913) and simulations (13,220). Stage was captured for 92.2% of Brocade episodes (8,513 of 9,236) versus 29.7% of courses pre-Brocade (3,025 of 10,170; P < .001). Quality assurance was documented for 96.3% of completed courses (7,601 of 7,892). The most common grade ≥1 toxicities were pain (10,031), fatigue (7,490), and dermatitis (6,172). Brocade implementation was associated with a reduction in off-hours documentation and increase in the proportion of documentation created between 8:00 am and 12:00 pm. Conclusion Brocade is a reliable Web-based EDC tool that improves clinical documentation without detracting from clinical workflow. Moreover, Brocade has the advantage of capturing data in a structured manner that facilitates real-time analytics and outcome reporting.
TRADISI MANDI BALIMAU DI MASYARAKAT KUNTU: Living Hadis Sebagai Bukti Sejarah
Authors: Iballa Dona Kahfi. MA. 
Published: September 2018

Living Hadis is respons of certain community of muslims which is based by a “hadis” itself. It is containing in personal or also in community life in human society. Living hadis is an acculturation or assimilation between Islam’s doctrine and some of local’s cultures. Acculturation and assimilation between them produces a tradition which is known as living tradition or if it is based on thought that the foundation of the tradition is Hadith, it is called by living hadis. One of a phenomenon of living hadis which is exists in Kuntu society is tradition of Mandi Balimau. It is can be understood as living hadis by two indications. First, its basic is to missionize doctrine of Islam’s missionary endeavor. Second, it is to put into practice a sacred text which is known by Kuntu society by hadis. Mandi Balimau as one of phenomenon of living hadis could be proof of history of first Islamization in Nusantara especially in Riau. It manifested that Kuntu is one of the first regions in Nusantara that Islam introduced with and it also proofed that process of islamization in Nusantara occurred tranquility.
Komik Hadis Nasihat Perempuan : Pemahaman Informatif dan Performatif
Authors: Suryadilaga Muhammad Alfatih 
Published: September 2018

Komik hadis semakin berkembang pesat di Indonesia. Setidaknya komik hadis ini adalah bahan bacaan bagi masyarakat awam baik anak-anak maupun remaja dalam memahami ajaran Islam, khususnya dalam hadis. Seperti ajaran Islam yang damai dengan digambarkan dengan baik melalui komik kapasitas perempuan yang dijelaskan masuk surga. Kemunculan komik hadis tersebut merupakan suatu yang baru karena pemahaman selama ini atas hadis-hadis dapat ditemukan hanya melalui ahli hadis terutama dalam syarah kitab-kitab hadis. Apalagi dalam beberapa kajian yang ada syarah hadis yang berkembang dalam sejarah hadis lebih banyak tidak berkembang pola pemahamannya antara masa Nabi Muhammad saw. sampai abad ke-8 H. Artinya, kontruk budaya masyarakat pemahaman hadis tidak mewarnai dalam kitab syarah hadis. Hal ini berbeda dengan komik hadis yang berkembang di Indonesia. Ciri khas ke-Indonesiaan dalam komik hadis tersebut sangat terasa. Dengan menggunakan teori performatif, maka kajian ini akan melihat tentang otoritas keilmuan syarah hadis dan hasil kajiannya sebagimana yang berkembang dalam informasi awalnya di masa Nabi saw.
Memahami Hadis Larangan Bid'ah dengan Melihat Fungsinya terhadap Konteks Sosial Masyarakat
Authors: Anshari Zaidan 
Published: September 2018

The problem of bid’ah, though a classic problem, remains a polemic. The division of bid’ah into sayyi'ah and hasanah seems to have no intersection between the supporters and the repellents. The problem can be observed through a variety of perspectives, one of which is the sociology perspective with the assumption that the bid'ah's prohibition is related to the social condition of the society when the hadith is revealed. This is evidenced by the different receptions of some shahabah after the death of the Prophet Muhammad, who decided to do some things previously never done by the Prophet Muhammad during his lifetime. This paper will attempt to disclose it. Where the social conditions of society at the time of prophethood have differences with the conditions after the death of the Prophet Muhammad, so some shahabah dare to decide a case that had never been done by the Prophet Muhammad. Persoalan bid’ah, meskipun merupakan masalah yang klasik, namun hingga kini tetap menyisakan polemik. Pembagian bid’ah kepada sayyi’ah dan hasanah seakan belum memiliki titik temu antara pendukung dan penolaknya. Persoalan tersebut sejatinya dapat diteropong melalui beragam perspektif, salah satunya adalah perspektif sosiologi dengan asumsi bahwa keputusan larangan bid’ah berkaitan dengan kondisi sosial masyarakat pada saat hadis tersebut diturunkan. Hal ini dibuktikan dengan perbedaan resepsi dari beberapa sahabat sepeninggal Nabi Muhammad, yang memutuskan untuk melakukan beberapa perkara yang sebelumnya tidak pernah dilakukan oleh Nabi Muhammad semasa hidupnya. Tulisan ini akan berupaya mengungkap hal tersebut. Di mana kondisi sosial masyarakat pada masa kenabian memiliki perbedaan dengan kondisi setelah wafatnya Nabi Muhammad, sehingga beberapa orang sahabat berani memutuskan sebuah perkara yang sebelumnya tidak pernah dilakukan oleh Nabi Muhammad.
Reflections on Sustainable Development Planning in the Agricultural Industry
Authors: TLESOVA Aigul , PRIMBETOVA Saule , KAZAMBAYEVA Aigul , YESSENGALIYEVA Saltanat , MUKHAMBETKALIYEVA Farida 
Published: September 2018

In the past few years, we have experienced a transition from the decades-long period of falling real prices of grains, and food more generally, to a new market environment in which commodity and food prices are higher, more volatile and more highly influenced by petroleum prices.
The problems of reaction for price volatility, both in the short- and long-run, are complex and multifaceted. Looking back at the 2007/08 crisis, countries responded through a spectrum of policies, but were largely unprepared, resulting in ad hoc and short-term mechanisms. Countries maintaining food reserves used these to intervene directly in the market to stabilize domestic prices. Many food importing countries reduced import tariffs, while several surplus producing countries limited, or even banned, exports in order to avoid food shortages and further domestic price increases. For whatever actions governments consider taking, it is always important to keep in mind the full set of policy measures, the wider risks and possible responses for the targeted population. The following suggests that choosing appropriate policies requires a deeper understanding of the issues at stake.
This paper analyses the various theoretical approaches to the planning of agricultural and food areas of Kazakhstan. The authors consider that the method of forecast scenarios is the most effective one.
Programmed - Aimed Approach to Sustainable Development Management. Regional Experience
Authors: TUREKULOVA Dametken , SATKANOVA Rimma , YESTURLIEVA Aigul , BERMUKHAMEDOVA Galiya , ASTAUBAYEVA Gulnar 
Published: September 2018

Author исследует управление процессом разработки, реализации, мониторинга и оценки Программы развития территории на материалах Карагандинской области. explores the management of the developing, implementation, monitoring and evaluation of Program on the territory development based on the regional materials to measure sustainability.
Выявленные в результате анализа проблемные зоны всех этапов управления государственной Программой развития территории за период с 2011-2015 года рассмотрены в работе с позиций мирового опыта оценки эффективности. The analysis the problem areas of all stages of management of the state program of territory development was used as starting point in assessing the effectiveness of public policy. В исследовании предпринята попытка решить теоретические и практические проблемы повышения эффективности государственного управления устойчивым развитием региона посредством улучшения методического обеспечения государственной Программы развития территории. The study reveals the attempt to solve theoretical and practical problems of increasing the efficiency of public administration in sustainable development of the region by improving the methodological support of the state program of development of the territory.
Актуальность темы исследования . The New Methodology ofpublic public management , ориентированного на результаты, вопрос обеспечения экономической эффективности при соблюдении баланса интересов общества и природы становится актуальным для государственных органов, реализующих политику устойчивого развития в разрезе регионов. Management which is results-oriented, the issue of cost-effectiveness while balancing the interests of society and nature becomes relevant for governments implementing policies for sustainable development across the regions. State program being a sophisticated tool of state regulation, is a set of projects (measures) and regulatory instruments. Она требует взаимодействия большого количества субъектов разного уровня в процессе разработки, организации и координации усилий участников программы, мониторинга, оценки промежуточных результатов для обратной связи и корректировки программы, и, наконец, оценки конечных результатов, которая позволяет судить об эффективности программы и достижении поставленных целей.It requires the cooperation of a large number of different levels of actors in the development, organization and coordination of the efforts of participants in the program, monitoring and evaluation of interim results for the feedback and adjustment programs, and finally, evaluation of outcomes, which allows you to judge the effectiveness of the program and the achievement of its goals.
The Innovative Model of Energy Efficient Village under the Conditions of Sustainable Development of Ecological Territories
Authors: YASNOLOB Ilona , CHAYKA Tetyana , GORB Oleg , Demianenko Nataliia , PROTAS Nadiia , HALINSKA Tetіana 
Published: September 2018

The topicality of raising the level of rural territories’ energy independence is substantiated in the article. Using the Ukrainian and foreign experience in creating and implementing the projects “energy efficient village”, the stages of its introduction have been determined. Taking into account the results of these projects in Ukraine, the conditions as to providing their efficiency have been defined.
The peculiarities of creating the energy independent and effective village have been considered; its conceptual model has been created. Some aspects of using biomass and its effectiveness as an alternative source of energy have been presented. The factors of ecological, social, and economic efficacy of developing and implementing the projects of “energy efficient village” on the rural territories of Ukraine have been determined. The actuality of developing and introducing the projects in the creation of energy independent rural territories is put into practice on the territory of Ukraine.
Composing of Scenarios Development in Strategic Planning
Authors: MUKANOV Aidar , SADUOV Askar , AKBAYEV Yerbolsyn , DULATBEKOVA Zhanar , OSPANOVA Anarkul , SELEZNEVA Irina , MADIYAROVA Elvira , JEMPEISSOVA Gulnara 
Published: September 2018

Abstract:
Today, there are different points of view on the strategic planning of the production activity at enterprises and approaches to its implementation. In conditions of high uncertainty and rapid changes in the surrounding environment developing a strategy, relying only on probabilistic forecast is too risky. In an unstable environment, there are many possible options of future, which raises the need to design scenarios for key areas of development.
In addition, it should be noted that many Russian enterprises during strategic planning of production activities "thinking scenario" has not taken root. In part, it happened due to of complication of development process and identification of scenario’s reliability. Preparation of the scenarios required significant time, while in most cases the whole system of industrial relations in the domestic enterprises built with reliance on short-term goals.
In the above scientific paper, the authors reveal some theoretical features of the strategic planning of production activities, the approaches formed in Russia according to strategic planning, as well as the importance of developing the scenarios in the planning of activities, which directed to achieve the strategic goals of the organization. The author notes that the main meaning of development scenarios for strategic planning of industrial activity is to construct different and equally plausible options for the production development in the future. It is emphasized that the development of scenarios should be one of basic conditions for the strategic planning of industrial activity, which is capable of quickly and effectively prepare the production process and the whole enterprise for the new economic conditions.
Etika Advokasi Public Relations dalam Manajemen Krisis Reputasi
Authors: Indrayani Heni 
Published: September 2018

AbstractIn handling the crisis company, Public Relations Proffesionals is required to balance the interests of companies and term of public interests. Public Relations Proffesionals often perform persuasion what course for sake of good company reputation. Here, ethics advocacy present into solutions dilematik between defending the interests of company and the public interests. In communicating to the public, Public Relations Proffesionals rests on a truth value, honesty, social responsibility, openness, loyalty, fair thinking, respect, integrity and communication frankly. The models of ethics in overcoming the crisis include Attorney Adversary Model, Two-way symmetrical model, Social Responsibility Model, Partisan versus Mutual Values Model, and Professional Responsibility Model. While ethical action Professional Public Relations in crisis management adhering to the code of professional conduct and codes of conduct to be able to behave or act as professionals in decision-making, and what procedures are done objectively, and be accountable. Keywords : Professional Public Relations, Advocacy ethics, Crisis Management
PRAKTIK PUBLIC RELATIONS DAN CORPORATE SOCIAL RESPONSIBILITY DALAM PERUBAHAN SOSIAL GLOBAL
Authors: Juwita Rina 
Published: September 2018

ABSTRAKThis paper tries to analyze the trends and patters working in public relations industry in term of Corporate Social Responsibility (CSR). Recent literatures from the PR scholars state that this field requires a broader approach in term of desaigning and implementing CSR rather than just being a small part of management communication function. However, as Clark proposed (2000), these activities should be integrated into the management function and become an important part of management component of the modern public relations. It is true since there are more positive opportunities in the implementation of social responsibility if it is integrated into the PR program if the approaches being used allows the establishment of a stronger relationship between organisation, stakeholders, and the public itself. Kata Kunci: Public Relations, CSR, Social Exchange