bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recyclable biobased materials based on Diels–Alder cycloaddition
Authors: Xu Jianan , Li Zhiying , Wang Bao , Liu Fengya , Liu Yudong , Liu Fengqi 
Published: January 2019

ABSTRACTPoly(ethylene glycol) diglycidyl ether‐furfurylamine (PGFA) containing pendant furan was synthesized, and a series of crosslinked materials with thermally reversible capacity were synthesized through a furan/maleimide Diels–Alder (DA) reaction between PGFA and bismaleimide (BMI). The kinetics of the PGFA/BMI DA reaction were studied by Fourier transform infrared spectroscopy (FTIR). The reaction conversion rate, the reaction rate constant, and the energy of the DA reaction at different temperatures were calculated. In addition, the retro Diels–Alder (rDA) reaction was studied via 1H‐NMR, differential scanning calorimetry, and in situ FTIR. The occurrence of the retro DA reaction has been characterized clearly. Finally, the mechanical properties of the materials were obtained by dynamic mechanical and tensile tests. The storage modulus decreased obviously when the temperature reached over 90 °C, which proved that the materials were thermally reversible at high temperature. By changing the proportion of the crosslinking agent BMI, the best‐performing materials were obtained, and the properties of the materials were basically unchanged after recycling. Thus we have obtained an excellent reusable material. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47352.
Effect of carboxyl content on the physicochemical properties and intramolecular water distribution of 6‐carboxyl chitooligomer prepared by laccase‐TEMPO
Authors: Bu Xin , Li Ying , Zhen Xiaoqin , Wang Jing , Zhang Xinli , Bian Nengyuan , Chan Huifang , Liu Kun , Zhang Fangdong , Pei Jicheng 
Published: January 2019

ABSTRACT6‐carboxyl chitooligomer was prepared by degradation of chitosan with H2O2 followed by catalytic oxidation in the laccase‐2,2,6,6‐Tetramethylpiperidine‐1‐oxyl (TEMPO) system. The TEMPO was used as a single variable to alter the content of introduced carboxyl groups. The resulting oxidation products were analyzed by ion chromatography, scanning electron microscopy, and 1H low‐field NMR. Moisture absorption‐retention ability, antioxidation, and thermal stability also were characterized. The results showed that the carboxyl content in the molecules increased with increasing TEMPO. With the addition of 8% TEMPO (mass fraction relative to chitooligomers), the carboxyl content and the oxidation degree of the product reached 4.90 mmol/g and 96.53%, respectively. Under these conditions, it also had the highest ABTS radical cation scavenging ability of 85.47% and improved thermal stability. When the amount of TEMPO was reduced to 2%, the oxidation product had a degree of oxidation of ~50% and showed a unique molecular structure and supreme moisture absorption‐retention ability. A higher associated water content was observed inside the molecules where more bound water was locked in the process of moisture absorption. Furthermore, the physicochemical properties of 6‐carboxyl chitooligomer were much higher than chitooligomer and oligomeric sodium hyaluronate (HA‐Oligo). © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47509.
A sliding mode control and artificial neural network based MPPT for a direct grid‐connected photovoltaic source
Authors: Touil Sid‐Ahmed , Boudjerda Nasserdine , Boubakir Ahsene , El Khamlichi Drissi Khalil 
Published: January 2019

AbstractA robust sliding mode controller for a grid‐connected photovoltaic source is proposed in this paper. The objective of the presented control scheme is to force both the output voltage of the photovoltaic PV source and the power factor at the inverter output to follow a certain trajectory reference. The main idea is to apply the robust sliding mode controller directly to the nonlinear state model of the system composed of the PV source and the inverter with its input and output filters. In order to operate the PV system at the maximum power point and to satisfy the environmental factors, such as solar irradiance and temperature, we included a rigorous maximum power point tracker based on an artificial neural network. Simulation results are presented to illustrate the performance of the proposed control scheme. In addition, we show that the grid current satisfies the harmonic limits of the IEEE standard for interconnecting distributed energy sources with electric power systems.
Inferring power and dominance from dyadic nonverbal interactions in autism spectrum disorder
Authors: Kuschefski Marius , Falter‐Wagner Christine M. , Bente Gary , Vogeley Kai , Georgescu Alexandra Livia 
Published: January 2019

Research studies to date have revealed conflicting results with respect to the processing of nonverbal cues from social interactions in autism spectrum disorder (ASD). Therefore, the aim of the present study was to investigate the contribution of two important factors for the perception of dyadic social interactions, namely (a) the movement contingency and (b) the spatial context. To this end, 26 adult participants with ASD and 26 age‐, sex‐, and IQ‐matched typically developed control participants observed animations presenting nonverbal interactions between two human virtual characters enacting power relationships. We manipulated (a) movement contingency by exchanging one of the two original agents with an agent from another dyad and (b) spatial context by changing agents' spatial orientation to a back‐to‐back position. Participants were asked to rate dominance and submissiveness of these agents. Results showed that the movement contingency manipulation affected accuracy and consistency of power perception and that the spatial context manipulation slowed down reaction times comparably in both groups. With regard to group differences, individuals with ASD were found to judge power relationships slower compared to control participants, potentially suggesting a more explicit processing style in ASD. Furthermore, the spatial context manipulation slowed down the reaction times more in the contingent compared to the non‐contingent conditions only in the ASD group. These findings contribute to the ongoing debate whether individuals with ASD have difficulties in understanding nonverbal cues in a dyadic context by suggesting that they do so in more subtle ways than previously investigated. Autism Res 2019, 12: 505–516 © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryThis study shows that the ability and speed of judging who is dominant in a social interaction depends on two factors: (a) whether their movements are matched and (b) whether they are facing each other or not. This is similarly the case for participants with and without autism. Interestingly, however, individuals with autism seem to judge generally slower, suggesting a more explicit processing style. The two factors seem to interact, suggesting that nonverbal processing difficulties are subtler than previously thought.
Adenylation Domains in Nonribosomal Peptide Engineering
Authors: Stanišić Aleksa , Kries Hajo 
Published: January 2019

AbstractNonribosomal peptides are a prolific source of bioactive molecules biosynthesized on large, modular assembly line synthetases. Synthetic biologists seek to obtain tailored peptides with tuned or novel bioactivities by engineering modules and domains of these nonribosomal peptide synthetases. The activation step catalyzed by adenylation domains primarily selects which amino acids are incorporated into nonribosomal peptides. Here, we review experimental protocols for probing the adenylation reaction that are applicable in natural product discovery and engineering. Several alternatives to the established pyrophosphate exchange assay will be compared and potential pitfalls pointed out. Binding pocket mutagenesis of adenylation domains has been successfully conducted to adjust substrate preferences. Novel screening methods relying on yeast surface display, for instance, search a larger sequence space for improved mutants and thus allow more substantial changes in peptide structure.
Personalized antiplatelet therapy in patients with coronary artery disease undergoing percutaneous coronary intervention: A network meta‐analysis of randomized clinical trials
Authors: Kheiri Babikir , Abdalla Ahmed , Osman Mohammed , Barbarawi Mahmoud , Zayed Yazan , Haykal Tarek , Chahine Adam , Bachuwa Ghassan , Hassan Mustafa , Bhatt Deepak L. 
Published: January 2019

AbstractObjectivesThis study aimed to evaluate the efficacy and safety of genotype‐ and phenotype‐guided intensified antiplatelet therapy compared with conventional therapy in patients undergoing stent implantation.BackgroundAlthough potent P2Y12 receptor inhibitors are recommended for percutaneous coronary intervention (PCI)‐treated acute coronary syndrome, their usage is limited by a high bleeding risk. Therefore, personalized antiplatelet therapy could provide a valuable foundation for selection of antiplatelet therapy in this population.MethodsWe conducted a Bayesian network meta‐analysis for all randomized clinical trials (RCTs) that evaluated genotype‐ and/or phenotype‐guided therapy in PCI‐treated coronary artery disease.ResultsThirteen RCTs were included with a total of 6,845 patients. The results showed no significant differences in major adverse cardiovascular events (MACE) between the treatment options ((genotype guided vs. standard of care; OR 0.64; 95% CI: 0.38–1.05) and (phenotype vs. standard of care; OR 0.93; 95% CI: 0.54–1.37)). In addition, no significant differences were demonstrated in bleeding events ((genotype guided vs. standard of care; OR 0.73; 95% CI: 0.45–1.25) and (phenotype vs. standard of care; OR 0.90; 95% CI: 0.62–1.39)).ConclusionsIn this mixed treatment meta‐analysis of RCTs, neither genotype‐ nor phenotype‐guided antiplatelet therapy in patients with PCI‐treated coronary artery disease was superior to conventional therapy.
Native kidney BK nephropathy: A case report
Authors: Al Zein Said , Price Hayley , Chen Guoli , Kaur Gurwant 
Published: January 2019

Key Clinical MessageBK virus nephropathy (BKN) is uncommonly reported in native kidneys; mostly reported in bone marrow transplant patients. This case report represents an interesting clinical scenario of biopsy‐proven BKN in native kidneys, in the presence of more than one million copies/mL of BK virus in serum.
Ventricular septal rupture following myocardial infarction: A potentially fatal complication
Authors: Saplaouras Athanasios , Sakellaropoulou Antigoni , Mililis Panagiotis , Bazoukis George , Kolokathis Angelos‐Michail , Konstantinidou Eleni , Anagnostou Aikaterini , Panagopoulou Niki , Vlachos Konstantinos , Lakoumentas Ioannis , Sideris Antonios 
Published: January 2019

Key Clinical MessageMechanical complications of acute myocardial infarction include ventricular septal rupture (VSR), free wall rupture, and ischemic mitral regurgitation. Postinfarction VSR is a rare but serious complication of myocardial infarction. VSR has a lower incidence in the era of new reperfusion therapies. However, clinicians should be aware of this potentially fatal complication as the mortality remains extremely high. Early diagnosis and treatment are the cornerstones of achieving a better outcome.
Aryl Boronic Acid Catalysed Dehydrative Substitution of Benzylic Alcohols for C−O Bond Formation
Authors: Estopiñá‐Durán Susana , Donnelly Liam J. , Mclean Euan B. , Hockin Bryony M. , Slawin Alexandra M. Z. , Taylor James E. 
Published: January 2019

AbstractA combination of pentafluorophenylboronic acid and oxalic acid catalyses the dehydrative substitution of benzylic alcohols with a second alcohol to form new C−O bonds. This method has been applied to the intermolecular substitution of benzylic alcohols to form symmetrical ethers, intramolecular cyclisations of diols to form aryl‐substituted tetrahydrofuran and tetrahydropyran derivatives, and intermolecular crossed‐etherification reactions between two different alcohols. Mechanistic control experiments have identified a potential catalytic intermediate formed between the aryl boronic acid and oxalic acid.
Selective Cre‐mediated gene deletion identifies connexin 43 as the main connexin channel supporting olfactory ensheathing cell networks
Authors: Piantanida Ana Paula , Acosta Luis Ernesto , Brocardo Lucila , Capurro Claudia , Greer Charles A. , Rela Lorena 
Published: January 2019

AbstractMany functions of glial cells depend on the formation of selective glial networks mediated by gap junctions formed by members of the connexin family. Olfactory ensheathing cells (OECs) are specialized glia associated with olfactory sensory neuron axons. Like other glia, they form selective networks, however, the connexins that support OEC connectivity in vivo have not been identified. We used an in vivo mouse model to selectively delete candidate connexin genes with temporal control from OECs and address the physiological consequences. Using this model, we effectively abolished the expression of connexin 43 (Cx43) in OECs in both juvenile and adult mice. Cx43‐deleted OECs exhibited features consistent with the loss of gap junctions including reduced membrane conductance, largely reduced sensitivity to the gap junction blocker meclofenamic acid and loss of dye coupling. This indicates that Cx43, a typically astrocytic connexin, is the main connexin forming functional channels in OECs. Despite these changes in functional properties, the deletion of Cx43 deletion did not alter the density of OECs. The strategy used here may prove useful to delete other candidate genes to better understand the functional roles of OECs in vivo.
VASP hits the memory wall: Processors efficiency comparison
Authors: Stegailov Vladimir , Smirnov Grigory , Vecher Vyacheslav 
Published: January 2019

SummaryFirst‐principles calculations of electronic structure have been one of the most important classes of supercomputer applications for a long time. In this paper, we consider VASP as a de facto standard tool for density functional theory calculations widely used in materials science, condensed matter research, and other related fields. The choice of hardware for the efficient VASP calculations is not easy because of the large number of processor types available. We use the benchmark metric that is based on the balance of the peak floating point performance and the memory bandwidth. This metric gives us the possibility to compare different types of processors. We consider time‐to‐solution and energy‐to‐solution criteria and compare different Intel, AMD, and ARM 64‐bit CPUs and hybrid CPU‐GPU systems based on Nvidia Tesla P100.
The emerging role of cranial nerves in shaping craniofacial development
Authors: Sudiwala Sonia , Knox Sarah M. 
Published: January 2019

SummaryOrgans and structures of the vertebrate head perform a plethora of tasks including visualization, digestion, vocalization/communication, auditory functions, and respiration in response to neuronal input. This input is primarily derived from afferent and efferent fibers of the cranial nerves (sensory and motor respectively) and efferent fibers of the cervical sympathetic trunk. Despite their essential contribution to the function and integration of processes necessary for survival, how organ innervation is established remains poorly understood. Furthermore, while it has been appreciated for some time that innervation of organs by cranial nerves is regulated in part by secreted factors and cell surface ligands expressed by those organs, whether nerves also regulate the development of facial organs is only beginning to be elucidated. This review will provide an overview of cranial nerve development in relation to the organs they innervate, and outline their known contributions to craniofacial development, thereby providing insight into how nerves may shape the organs they innervate during development. Throughout, the interaction between different cell and tissue types will be highlighted.
Long‐term water balance partitioning explained by physical and ecological characteristics in world river basins
Authors: Mercado‐Bettín Daniel , Salazar Juan F. , Villegas Juan Camilo 
Published: January 2019

AbstractFor decades, scientists have debated the relation between physical attributes and vegetation and the partitioning of rainfall (P) into evaporation (E) and run‐off (R) in basins. Physical and ecological processes explain the long‐term behaviour of E via water or energy limitations. Needed are similar globally applicable frameworks for describing the production of streamflow and its interaction with factors influencing E, to produce long‐term patterns of E–R partitioning. Here, we analyse 131 independent river basins that flow naturally (or with minimum intervention to their flow) in three major world regions (tropical, temperate, and boreal). We relate water balance partitioning to physical and ecological attributes in these basins to show how P partitioning into E and R is significantly related to the amount of forest and Shrub‐Grass‐Savannas cover in tropical and temperate basins and mostly influenced by slope and Shrub‐Grass‐Savannas cover in boreal basins. Our results highlight that in tropical and temperate basins, if not limited by water, partitioning tends to be equally distributed between E and R as forest cover increases. When Shrub‐Grass‐Savannas cover increases, E dominates, indicating water limitations. In boreal basins, the partitioning does not respond to forest cover, potentially due to the effects of snowmelt and geomorphology. According to normalized difference vegetation index observations, the dominance of E is more related to land cover and seasonality than to vegetation activity. Current processes including deforestation in the tropics, forest die‐off in temperate regions, and afforestation in boreal regions can influence other societally important environmental processes, such as the production of river flow regimes.
Charting knowledge co‐production pathways in climate and development
Authors: Harvey Blane , Cochrane Logan , Van Epp Marissa 
Published: January 2019

AbstractClimate change poses significant global challenges. Solutions require new ways of working, thinking, and acting. Knowledge co‐production is often cited as one of the innovations needed for navigating the complexity of climate change challenges, yet how to best approach co‐production processes remains unclear. In this article, we explore the ways in which climate and development researchers are approaching the co‐production of knowledge and grapple with the extent to which the modalities used are reaching their stated potential. Using a multiple case analysis of six examples of successful co‐production, we outline a spectrum of co‐production approaches and outcomes and examine the drivers and challenges to co‐production in practice. Drawing on the case evidence and literature, we propose a heuristic that maps out this spectrum of aims and approaches to co‐production and that could inform reflections on how those planning co‐production processes envision them in practice.
Determination of 4‐Nitrobenzaldehyde in Water Samples by Combination of Switchable Solvent Based Microextraction and Electrochemical Detection on MWCNTs Modified Electrode
Authors: Ahmar Hamid , Shahvandi Siamak Kiani 
Published: January 2019

AbstractA novel approach is presented to determine 4‐nitrobenzaldehyde in water samples. The procedure is based on switchable solvent based liquid‐liquid microextraction (SS‐LLME) and then determination by differential pulse voltammetry at multi‐walled carbon nanotubes modified glassy carbon electrode. Dipropylamine, a solvent with switchable polarity, was used as an extraction solvent that can be miscible/immiscible upon the changes of pH of sample solution. Effects of experimental conditions on SS‐LLME were investigated using a one‐factor‐at‐a‐time methodology. Under optimized conditions, a calibration curve was linear in the concentration range of 1.0 and 350 μg L−1. Limits of quantification and detection were empirically 1.0 μg L−1 and 0.3 μg L−1, respectively. Intraday and Interday RSDs%, calculated in three concentration levels, were in the range of 6.2–7.8 % confirm the proper precision of the method. Finally, the performance of the method was evaluated successfully in real samples including drinking water, tap water and river water.
Electrosynthesis of Molecularly Imprinted Poly‐o‐phenylenediamine on MWCNT Modified Electrode for Selective Determination of Meldonium
Authors: Güney Sevgi 
Published: January 2019

AbstractIn this study, a molecularly imprinted polymer (MIP) was synthesized by electrochemical polymerization and used to construct an electrochemical sensor for determination of meldonium (MEL) selectively for the first time. The polymer film was generated by using o‐phenylenediamine (o‐PD) as a monomer on the surface of carboxylic acid functionalized multiwalled carbon nanotube (MWCNT) modified pencil rod electrode in the presence of MEL as a template. MEL imprinted (MEL‐imp) and non‐imprinted (N‐imp) polymer films and coated electrodes were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), profilometry, electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Voltammetric measurements were carried out in a ferrocyanide/ferricyanide redox probe solution for MEL‐imp and N‐imp electrodes in the presence and absence of template molecule. The decrease in peak current of redox probe was linear with the concentration of MEL in the range of 0.1–5 μg/mL and the limit of detection (3 s/b) was found to be 0.066 μg/mL under optimized experimental conditions. The proposed sensor was successfully applied for selective determination of MEL in human urine sample with long term stability and good reproducibility.
Nitrogen‐doped Hollow Co3O4 Nanofibers for both Solid‐state pH Sensing and Improved Non‐enzymatic Glucose Sensing
Authors: Dong Qiuchen , Wang Xudong , Willis William S. , Song Donghui , Huang Yikun , Zhao Jing , Li Baikun , Lei Yu 
Published: January 2019

AbstractNitrogen‐doped hollow cobalt oxide nanofibers (Co3O4 NFs) with both glucose catalytic activity and pH sensitivity were fabricated through core‐sheath electrospinning technique, followed by calcination. The as‐developed nitrogen‐doped hollow Co3O4 NFs were thoroughly characterized using various techniques, and then employed to fabricate a dual electrochemical sensor for both pH sensing and glucose sensing. The pH sensitivity of the developed nitrogen‐doped hollow Co3O4 NFs demonstrated a Nernst constant of 12.9–15.9 mV/pH in the pH range of 3.0∼9.0 and 6.8–10.7 mV/pH in the pH range of 9.0∼13.0, respectively. The developed hollow cobalt oxides nanofibers sensor also possesses glucose sensitivity of 87.67 μA mM−1 cm−2, the limit of detection of 0.38 μM (S/N=3), and an acceptable selectivity against several common interferents in non‐enzymatic glucose determination. High accuracy for monitoring glucose in human serum sample was also demonstrated. These features indicate that the as‐synthesized nitrogen‐doped hollow cobalt oxides nanofibers hold great potential in the development of a unique dual sensor for both solid‐state pH sensing and superior non‐enzymatic glucose sensing.