bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes of the erythrocyte phenotype and blood biochemistry in dairy calves during the first ten weeks of age
Authors: Golbeck Lennart , Cohrs Imke , Scheu Theresa , Grünberg Walter 
Published: July 2019

BackgroundBovine erythrocytes undergo important changes in their morphology and chemical composition during the first weeks of age, which must be understood to accurately interpret hematology results in calves. The objectives of this prospective cohort study were to describe physiological changes of calf erythrocytes and to investigate mechanisms potentially causing these changes.MethodsBlood samples from 30 clinically healthy dairy calves were obtained from birth to the tenth week of age in weekly intervals. Hematological and plasma biochemical parameters as well as the mineral electrolyte content of erythrocytes were determined and followed over time. The changes of parameters characterizing the erythrocyte phenotype over time were compared to the changes of plasma and erythrocyte biochemical parameters and possible associations were investigated using correlation and stepwise regression analyses.ResultsAlthough the erythrocyte mean corpuscular volume (MCV) declined from 43.6 ± 3.7 fL to 35.6 ± 3.2 fL between the first and seventh week, the red blood cell count (RBC) increased from 7.2 ± 1.1 × 1012/L to 9.3 ± 1.0 × 1012/L until the fifth week of age. The blood hemoglobin (Hb) concentration increased from 0.96 ± 0.16 g/L to 1.16 ± 0.11 g/L in the first three weeks of age and remained at this level until the end of the study. Changes in MCV were accompanied by a decline of the erythrocyte potassium content (KERY) from 91.9 ± 13.5 to 24.6 ± 7.2 mmol/L and a concomitant increase of the erythrocyte sodium content from 45.0 ± 32.0 to 102.7 ± 26.5 mmol/L. MCV was found to be associated with KERY, the primary determinant of the intra-erythrocyte osmotic pressure from the sixth week of age and with blood hemoglobin, the primary determinant of the intra-erythrocyte oncotic pressure from the eighth week of age, when KERY, blood Hb and MCV already had reached or approached normal levels of adult cattle. The plasma iron concentration was not found to be associated to any of the studied hematological parameters.ConclusionA volume reduction of 20% in bovine neonatal erythrocytes is a physiological change occurring during the first weeks of age and is neither associated with sideropenia nor with anemia in healthy calves. The mechanism driving the observed erythrocyte volume change could not be identified. Results of the correlation and regression analyses indicate that changes in intra-erythrocyte osmotic or oncotic pressure are improbable underlying causes. Results reported here show that KERYis an unreliable indicator for the K homeostasis of the intracellular space in neonatal calves and that a decrease in MCV in early life per-se is an unreliable indicator for the development of microcytic anemia.
Development and evaluation of a training program for occupational health nurses regarding support for workers with cancer and their workplaces
Authors: Nishikido Noriko , Sasaki Minako , Yoshikawa Etsuko , Ito Michiyo 
Published: July 2019

Abstract

Objectives
This study aimed to develop and evaluate a training program for occupational health nurses (OHNs) regarding support for workers with cancer and their workplaces.

Methods
Based on our prior research, we engaged in multiple discussions on the development of training program for OHNs. For examining the effectiveness of the developed training program, we collected and analyzed the data from three repeated surveys conducted before, immediately after, and 3 months after the training on self-confidence levels of the participants regarding 23 items associated with support for workers with cancer and their workplaces.

Results
We made a 3-hour training program including a lecture and a group work. First, we gave a lecture explaining the support scheme consisting of 4 parts and the 12 hints in action phrase while using the guidebook. Second, we conducted the group work regarding the case of a female worker diagnosed with breast cancer. Of the participants who supported workers with cancer in actuality during the 3-month post-training, 86% acknowledged the utility of the training in implementing support. As for the pre-post evaluation of the training program, most items of the participants’ self-confidence significantly increased from pretraining to immediately after and 3 months post-training.

Discussion
This study demonstrated that the developed training program was effective in that the participants learned the support schemes and skills and gained self-confidence in implementing supports in real-work settings. We hope that this training program will be extensively used in the future, enabling OHNs to contribute toward balancing cancer treatment and work.
Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces hepatic dyslipidemia
Authors: Vineeth Daniel P. , Kamthan Mohan , Gera Ruchi , Dogra Surbhi , Gautam Krishna , Ghosh Debabrata , Mondal Prosenjit 
Published: July 2019

Dysregulated hepatic de novo lipogenesis contributes to the pathogenesis of nonalcoholic fatty liver disease in both humans and rodents. Clinical evidence suggests fatty liver to have a positive correlation with serum lead (Pb2+) levels. However, an exact mechanism of Pb2+‐induced fatty liver progression is still unknown. Here, we show that exposure to Pb2+ regulates ChREBP‐dependent hepatic lipogenesis. Presence of Pb2+ ions within the hepatocytes reduces transcript and protein levels of sorcin, a cytosolic adaptor partner of ChREBP. Adenovirus‐mediated overexpression of sorcin in Pb2+ exposed hepatocytes and an in vivo mouse model ameliorates liver steatosis and hepatotoxicity. Hereby, we present Pb2+ exposure to be a lethal disruptor of lipid metabolism in hepatocytes and highlight sorcin as a novel therapeutic target against Pb2+‐induced hepatic dyslipidemia.
Decarboxylative Coupling Reaction of 2‐(1H‐Indol‐3‐yl)acetic Acids with Indole, Azaindole, Benzimidazole and Indazole Derivatives
Authors: Pillaiyar Thanigaimalai , Uzair Muhammad , Ullah Saif , Schnakenburg Gregor , Müller Christa E. 
Published: July 2019

Abstract3,3′‐Diindolylmethanes (DIMs) are an important class of indole alkaloids that exhibit anti‐inflammatory and anti‐cancer effects. Herein, we report on a new, mild and efficient copper(II)‐promoted decarboxylative coupling reaction of 2‐(1H‐indol‐3‐yl)acetic acid derivatives (1 a–h) with a variety of (substituted) indoles (2 a–t) yielding (un)symmetrically substituted DIMs (3 a–z, 3 aa–ai). Reaction of 2‐(1H‐indol‐3‐yl)acetic acid (1 a) with 7‐azaindole led to the 3,3′‐connected DIM analog 5 d, while 4‐, 5‐, and 6‐azaindoles and benzimidazole reacted at the N1‐nitrogen atom. Reaction of 1 a with 1H‐indazoles led to a mixture of 1‐ and 2‐substituted indazole derivatives. The new method allows large‐scale synthesis of biologically active DIMs.magnified image
Enantioselective Synthesis of β‐Methyl Amines via Iridium‐Catalyzed Asymmetric Hydrogenation of N‐Sulfonyl Allyl Amines
Authors: Cabré Albert , Verdaguer Xavier , Riera Antoni 
Published: July 2019

AbstractThe iridium‐catalyzed asymmetric hydrogenation of several N‐sulfonyl allyl amines is reported. All substrates can be easily obtained by the Ir‐catalyzed isomerization of N‐tosylaziridines reported previously. The commercially available threonine‐derived phosphinite (UbaPHOX) iridium complex has been found to be the best catalyst for this catalytic application, affording β‐methyl amines with good to excellent ee values (up to 94%). The synthetic potential of this novel methodology was demonstrated by the formal synthesis of Lorcaserin and LY‐404187.magnified image
Chemoselective Kumada‐Type Iron Catalysis with Alkyl Grignard Reagents: Reductive Cyclization and Cyclomethylation
Authors: Kim Jae Gon , Baek Jong Hwa , Kim Ye Ji , Jang Yu Jeong , Kang Eun Joo 
Published: July 2019

AbstractA chemoselective reductive cyclization and cyclomethylation reaction of 7‐iodohept‐2‐yne and 7‐iodohepta‐1,2‐diene derivatives has been carried out using an iron catalyst and various alkyl Grignard reagents, resulting in the formation of pyrrolidines, tetrahydrofurans, and carbocycles with an alkene functional group. The reaction is initiated by single‐electron transfer from reduced Fe species to alkyl iodides and the resulting Fe−H or Fe−Me compound differentiated the structures of the cyclized products, which exhibited diverse complexities and synthetic utilities.
Chiral Conflict as a Method to Create Stimuli‐Responsive Materials Based on Dynamic Helical Polymers
Authors: Alzubi Mohammad , Arias Sandra , Rodríguez Rafael , Quiñoá Emilio , Riguera Ricardo , Freire Félix 
Published: July 2019

AbstractA new multi‐sensor material based on helical copolymers showing the chiral conflict effect have been prepared. It can successfully detect and identify diverse metal cations in solution. The design of this material has taken into account not only the opposite helical senses induced by the two chiral monomers in the copolymer, but also their dynamic behavior. The induced helical sense can thus be enhanced, diminished, or inverted by interaction with different stimuli (that is, metal ions). Thus, depending on both the copolymer compositions (such as monomer ratios and absolute configurations) and the nature of the metal ion, the response of these dynamic helical copolymers to adopt a single‐handed P or M helix is unique, making it possible not only to detect their presence, but also to identify them individually. New multi‐sensors materials based and inspired on this effect should arise in the future choosing appropriate monomers and stimuli.
Hydrated‐Metal‐Halide‐Based Deep‐Eutectic‐Solvent‐Mediated NiFe Layered Double Hydroxide: An Excellent Electrocatalyst for Urea Electrolysis and Water Splitting
Authors: Zhang Chenyun , Chen Tingting , Zhang Hong , Li Zhonghao , Hao Jingcheng 
Published: July 2019

AbstractThe liquid structures of deep eutectic solvents (DESs) based on hydrated metal halides and their application as electrolytes have been widely studied. However, little attention has been paid to the direct use of this type of DES in the preparation of micro‐/nanomaterials. Herein, an FeCl3⋅6 H2O/urea DES was used in the one‐step synthesis of NiFe‐LDH_D with a nanoflower morphology. In alkaline media, this catalyst promoted excellent electrocatalytic activity for the oxidation of urea at potential of 1.32 V (vs. RHE) and for the oxygen‐evolution reaction at a potential of 1.39 V to achieve a current density of 10 mA cm−2. These results were superior to the results with NiFe‐LDH/NF that was obtained from an aqueous solution of FeCl3, as well as most of the previously reported transition‐metal catalysts. Furthermore, NiFe‐LDH_D/NF could be readily implemented as both a cathode and an anode for the electrolysis of urea and water splitting. The use of hydrated‐metal‐halide‐based DESs for the preparation of LDH catalysts through a dipping‐redox strategy should both enrich the research of DESs and offer guidance for the rational surface engineering of catalysts for the electrolysis of urea and overall water splitting with high performance.
Control for networked control systems with packet dropout and delay
Authors: Liang Xiao , Yang Lei , Lu Xiao , Wang Haixia , Zhang Zhiguo 
Published: July 2019

AbstractThis paper mainly focuses on the optimal control and stabilization for networked control systems with packet dropout, measurement delay and input delay. The main contributions are two‐fold. Firstly, a necessary and sufficient condition for the finite horizon optimal control problem is obtained. Secondly, a necessary and sufficient condition for the stabilization problem is developed. Moreover, it has been proved that under standard assumptions the stabilizing condition depends merely on the eigenvalue of the system matrix and the probability of packet dropout which is irrelevant to measurement delay and input delay.
Dynamics and control of singular boolean networks
Authors: Qi Hongsheng , Qiao Yupeng 
Published: July 2019

AbstractConsider a class of singular Boolean networks, which consist of two parts: difference part and algebraic part. Using the truth matrix of the algebraic part, the trajectories of the networks are obtained and certain properties are investigated. Then the results are extended to Boolean control networks and the controllability of singular Boolean control systems is investigated. Necessary and sufficient conditions are obtained.
Maternal use of antibiotics and cancer incidence risk in offspring: A population‐based cohort study in Manitoba, Canada
Authors: Ye Xibiao , Monchka Barret A. , Righolt Christiaan H. , Mahmud Salaheddin M. 
Published: July 2019

AbstractSeveral epidemiological studies have found an association between maternal antibiotics use during pregnancy and increased risk of certain cancer types, although conclusions differ between studies. We examined this association in a cohort study including 262 116 mother‐child pairs of Manitoba births between 1996 and 2013. Maternal antibiotics use during prepregnancy (6 months prior to pregnancy) and pregnancy periods was assessed. Children's cancer incidence was tracked up to the end of the follow‐up period (December 2015). We calculated incidence rate and used Cox regression to estimate adjusted hazard ratios (HRs). Antibiotics use during pregnancy was not associated with overall cancer (HR = 1.1, 95% confidence interval 0.9‐1.4), leukemias (1.3, 0.9‐1.8), or acute lymphocytic leukemia (1.1, 0.7‐1.6). The association between antibiotics use and overall cancer risk differed by trimester: 1.5 (1.1‐1.9) in the first, 0.8 (0.6‐1.0) in the second, and 1.1 (0.8‐1.5) in the third trimester. Further research is necessary to confirm the association between first‐trimester exposure and cancer risk after a better controlling of confounding factors.
Homozygous familial hypercholesterolemia with stenosis of the left anterior descending coronary artery successfully treated with weekly low‐density lipoprotein apheresis for 16 years without percutaneous coronary intervention
Authors: Yasu Takanori , Shimoyama Masahiro , Wada Hiroshi , Iwakura Tomohiro , Toyoda Shigeru , Kawabe Atsuhiko , Sugiyama Takushi 
Published: July 2019

AbstractWe successfully treated a patient with homozygous familial hypercholesterolemia (HoFH) with stable coronary arterial disease using optimal medical therapy and low‐density lipoprotein (LDL) apheresis for 16 years without percutaneous coronary intervention or bypass surgery. Intensive LDL lowering using apheresis and medication protected the patient from coronary atherosclerotic progression even in HoFH.
Sintering Resistance of Pt@SiO2 Core‐Shell Catalyst
Authors: Kim Seunghyun , Lee Siwon , Jung WooChul 
Published: July 2019

AbstractAlthough core‐shell catalysts have been actively studied for their excellent stability at high temperatures, most studies have focused on the development of synthetic methods and not conducted actual catalytic reactions at conditions, under which particles severely agglomerate. Here, we prepare a model catalyst with a well‐defined size and interface of a Pt core and a gas‐permeable SiO2 shell via advanced colloidal synthesis, and evaluate the catalytic response to CO and CH4 oxidation, each representing low (<300 °C) and high (>500 °C) temperature reactions. Compared to typical SiO2 supported Pt, the core‐shell configuration shows comparable activity at CO oxidation and a much higher activity and stability for CH4 oxidation. However, even for the core‐shell, degradation is inevitable, and possible reasons for this are discussed. These practical results on high‐temperature catalysis provide important evaluation criteria and design guidelines for sintering‐resistant nanocatalysts.
In‐situ Growth of a Bimetallic Cobalt‐Nickel Organic Framework on Iron Foam: Achieving the Electron Modification on a Robust Self‐supported Oxygen Evolution Electrode
Authors: Luo Pei , Li Shixiong , Zhao Yasi , Ye Guojie , Wei Cong , Hu Yun , Wei Chaohai 
Published: July 2019

AbstractAs a clean energy source, hydrogen may be obtained via overall water splitting. However, the reaction is limited by the anodic oxygen evolution reaction (OER) in the catalytic field. In order to overcome the limitation in OER catalyst activity, this paper attempts to synthesize and develop a series of three‐dimensional metal‐organic frameworks (MOFs) electrocatalytic materials. The structure and morphology of bimetallic cobalt and nickel MOFs are characterized by FT‐IR, Raman, SEM, TEM, and XPS. It is found that the bimetallic cobalt and nickel MOFs have a columnar micro‐structure assembled by nanosheets. Further in‐situ growth on the iron (Fe) foam to prepare an integrated nanoarray self‐supported electrode did not significant change their micro‐structure. The obtained bimetal electrocatalysts exhibit significantly enhanced OER activity as compared to the single‐metal MOFs counterpart. The cobalt and nickel double‐doped materials in‐situ grown on Fe foam exhibited an excellent electrocatalytic activity and remarkable durability with a current density of 10 mA cm−2 in a 0.1 M KOH solution (with the overpotential of 264 mV and the Tafel slope of 54.3 mV dec−1). There is a significant improvement compared with the material on the glassy carbon electrode. The introduction of the bimetal species (Co and Ni) into the ordered MOFs provides a synergistic effect of the active centers resulting in an enhanced electron transfer and improved electrochemical performance. This work enriches the MOFs electrocatalytic electrode and pave the way for their practical applications.
Molecular Precursors for Tailoring Humidity Tolerance of Nanoscale Hopcalite Catalysts Via Flame Spray Pyrolysis
Authors: Wegner Karl , Zippel Rene , Medicus Maximilian , Schade Elke , Grothe Julia , Kaskel Stefan 
Published: July 2019

AbstractA systematic investigation of copper‐ and manganese‐carboxylate precursors derived from various organic acids (arylcarboxylate, alkylcarboxyate) and their transformation into copper manganese nanoparticles via flame spray pyrolysis (FSP) reveals significant impact on their physical and catalytic properties. A sodium‐free protocol is essential to achieve high purity copper(II) and manganese(II) 2‐ethylhexanoates, benzoates, 1‐naphthenates and 9‐ anthracenates as revealed by infrared spectroscopy (IR) and thermogravimetry (TG). In order to exclude the influence of other parameters, the FSP syntheses were carried out using fixed air/feed ratio. Especially aromatic precursors lead to smaller nanoparticles with high surface areas up to 180 m2g−1 and that these also have a higher carbon content. TPR investigations have shown that the copper and manganese atoms are in close contact with each other, which significantly reduces their reduction temperature. In catalytic CO oxidation, all samples synthesized from organometallic precursors have shown higher CO conversions at room temperature under dry conditions and improved long‐term stability under wet conditions compared to a commercial reference. The activity depends mainly on the Cu : Mn ratio and the specific surface area. At room temperature under dry conditions, catalytic CO conversion exceeding 80 % could be achieved. A decreased deactivation rate under humid conditions could be related to an increased carbon content of the nanocatalysts. By optimization of the synthesis parameters and the use of pure precursors, it was possible to show that flame spray pyrolysis is an efficient, scalable and single‐stage synthesis method for Hopcalite nanoparticles, which additionally provides more active catalysts than those from alternative synthesis methods.
Nickel Exsolution‐Driven Phase Transformation from an n=2 to an n=1 Ruddlesden‐Popper Manganite for Methane Steam Reforming Reaction in SOFC Conditions
Authors: Vecino‐Mantilla Sebastián , Gauthier‐Maradei Paola , Huvé Marielle , Serra José Manuel , Roussel Pascal , Gauthier Gilles H. 
Published: July 2019

AbstractAn original way to perform the exsolution of Ni nanoparticles on a ceramic support was explored for the development of methane steam reforming catalyst in SOFC anode conditions. The n=2 Ruddlesden‐Popper (RP) phase La1.5Sr1.5Mn1.5Ni0.5O7±δ has been synthesized by the Pechini method and subsequently reduced with an H2‐N2 mixture at different temperatures and reducing times to induce the formation of two phases: LaSrMnO4 (n=1 RP) decorated with metallic Ni nanoparticles. Preliminary measurements of catalytic behavior for the steam reforming have been carried out in a reduction‐reaction process with a mixture of 82 mol %CH4, 18 mol %N2 and low steam to carbon ratio (S/C=0.15). The catalyst exhibits a selectivity for CO production (0.97), 14.60 mol % CH4 conversion and around 24.19 mol % H2 production. Such catalytic behavior was maintained for more than 4 h, with a constant rate of hydrogen production and CH4 conversion rate.
Bimetallic Synergy Effects of Phyllosilicate‐Derived NiCu@SiO2 Catalysts for 1,4‐Butynediol Direct Hydrogenation to 1,4‐Butanediol
Authors: Wang Changzhen , Tian Yani , Wu Ruifang , Li Haitao , Yao Benzhen , Zhao Yongxiang , Xiao Tiancun 
Published: July 2019

AbstractHydrogenation of 1,4‐butynediol (BYD) to 1,4‐butanediol (BDO) is a two‐step process, with an initial hydrogenation of BYD to 1,4‐butenediol (BED) and the subsequent hydrogenation of BED to BDO. However, the BYD hydrogenation also involves many side reactions originated from the isomerization of BED. In order to inhibit the isomerization pathways, phyllosilicate‐derived bimetallic NiCu@SiO2 catalysts have been developed for efficient C≡C/C=C hydrogenation in this work. Due to the formation of phyllosilicate matrix and highly dispersed metal nanoparticles, NiCu@SiO2 showed total BYD conversion with extremely high BDO selectivity compared to a conventional impregnated Ni/SiO2 catalyst. A remarkable result of NiCu@SiO2 catalysts is that a new type of bimetallic catalytic sites responsible for the high hydrogenation activity can be differentiated from the Ni phyllosilicate matrix by the induction of Cu species, and these neighboring bimetallic sites with the help of weak acid phyllosilicate interface, can realize to stabilize the activated BED species (allyl alcohol form) adsorbed on the cooperative active sites, thus to avoid its isomerization to aldehyde form and unexpected C=O hydrogenolysis. Consequently, it enhanced the selectivity to the diol products BDO significantly. Owing to the benign improvement of three center synergy effect, 9Ni1Cu@SiO2 possesses the optimum BYD direct hydrogenation ability with a rarely reported high selectivity of 90.5–94.5 % at 50 °C and 1 MPa.
Nitrogen‐Doped NiO Nanosheet Array for Boosted Electrocatalytic N2 Reduction
Authors: Wang Xiao‐hu , Wang Jing , Li Yu‐biao , Chu Ke 
Published: July 2019

AbstractElectrocatalytic N2 reduction reaction (NRR) provides a sustainable approach for ambient N2 fixation. Non‐noble transition metal‐based electrocatalysts (TMEs) are emerging as the most promising NRR catalysts, but commonly exhibited limited NRR activity. Heteroatom doping is an effective method to improve the electrocatalytic activity of TMEs by finely modulating the electronic structures. Herein, as a proof‐of‐concept, nitrogen‐doped NiO nanosheet array on carbon cloth (N‐NiO/CC) was investigated as model heteroatom‐doped TMEs for NRR. The N‐NiO/CC exhibited the considerably enhanced NRR performance with a NH3 yield of 22.7 μg h−1 mg−1 and an FE of 7.3 % in 0.1 M LiClO4 at −0.5 V (vs. RHE), far superior to those of undoped counterpart. Density functional theory (DFT) calculations revealed that the N‐doping could induce the enhanced surface conductivity and upraised d‐band center, leading to promoted *NNH stabilization, reduced reaction energy barrier and thus improved NRR performance.