bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data Resource Profile: The Danish National Hospital Medicine Register
Authors: Andersen Michael Asger , Jensen Thomas Leth , Petersen Tonny Studsgaard 
Published: November 2024

ABSTRACTPurposeThe Danish National Hospital Medicine Register (SMR) was established in 2018 to centralize and standardize medication use data across Danish hospitals. This task was previously managed by individual hospital registration systems across the five regions. This initiative addresses the need for a unified, detailed understanding of hospital medication use to monitor healthcare delivery, improve patient outcomes, and support research.MethodsThe SMR has comprehensive coverage of medication use in hospitals in Denmark, offering a national overview that was previously missing. It features high‐quality data, with efforts to ensure completeness and accuracy. The data collected encompasses key categories such as types of medications, doses, administration times and practices, and specific treatment indications. The SMR facilitates collaboration among Danish regional health authorities and national health agencies, enhancing decision‐making and planning across the regions.ResultsThe establishment of the SMR has provided a centralized and standardized database for medication use across Danish hospitals. This unification replaces the previously fragmented systems, allowing for better monitoring of healthcare delivery and supporting improvements in patient outcomes and research.ConclusionThe upcoming version of the SMR will include data on dispensed outpatient medications, covering most medication use across all hospitals. This expansion will further enhance the register's utility for health authorities, clinicians, and researchers by providing a more comprehensive understanding of medication use in Denmark.
Climatic Specific Energy Rating Analysis of Outdoor PV Field Data
Authors: Lyubenova Teodora S. , Medina Ismael , Dunlop Ewan D. 
Published: November 2024

ABSTRACTThe IEC 61853 standard series define the Climatic Specific Energy Rating (CSER), which can be used within the photovoltaic (PV) community as a reliable and accurate tool to differentiate between PV modules performance for different reference climates. The CSER is assumed to represent the expected PV device operation under real‐world conditions. The rating model combines a set of measurements on modules with a numerical approach. So far, research has mainly focused on the implementation of algorithms to determine the input parameters and to calculate the CSER values based on indoor measurement performance data. There is lack of information and technical specification how to obtain these parameters from outdoor PV field data in natural sunlight. In the present study, we first estimated the CSER parameter (according to IEC 61853‐3) for a PV module tested indoor using input values measured or defined according to IEC 61853‐1&2 with associated measurement uncertainties. Then, we analysed long‐term outdoor field data of the same device for a period of 36 consecutive months in order to understand how the length and seasonality of the data acquisition period impacts the reliability of irradiance and temperature power matrix values, particularly in relation to CSER calculations. Uncertainties estimations for the outdoor procedure have been also defined for rating accuracy. The PV outdoor performance has been validated against its indoor counterpart. The results concluded that a period of 9 or 12 months provides a good compromise between accuracy, time and cost‐effectiveness. The time period may be reduced to 6 months if the meteorological conditions are sufficiently diverse in this time frame. The study might raise worthwhile discussion regarding the revision of the IEC 61853‐1 for determining the (G‐T) matrix of PV modules from outdoor measurements under natural sunlight. It could enhance important insights to the PV community since the CSER parameter may become a compulsory requirement for each PV module produced, imported or sold in Europe if the potential European Union (EU) Ecodesign Directive and the Energy Labelling Regulation will be implemented.
Psoas muscle index in sarcopenia following transjugular intrahepatic portosystemic shunt: A multicenter, retrospective study
Authors: Li Tongqiang , Wang Ze , Liu Yang , Dai Liguo , Zhu Xiaoli , Liu Jiacheng , Guo Qikun , Luo Weijie , Bai Yaowei , Luo Wei , Chu Menglan , Feng Duiping , Xiong Bin 
Published: November 2024

AbstractAimsAlthough the skeletal muscle index at the third lumbar vertebra (L3‐SMI) is commonly utilized for the diagnosis of sarcopenia, the psoas muscle index at L3 (L3‐PMI) may serve as a reliable alternative indicator. This study aims to investigate the application of the PMI in patients who have undergone transjugular intrahepatic portosystemic shunt (TIPS).MethodsThis study included a cohort of 406 patients with cirrhosis who underwent TIPS between February 2016 and July 2022 across three medical centers in China. Clinical and imaging data, specifically L3‐SMI and L3‐PMI, were collected for these patients. The prognosis of the patients was assessed through re‐examinations and telephone follow‐ups, which extended up to 5 years. The diagnostic thresholds for sarcopenia, as defined by L3‐PMI and L3‐SMI, were established at 6.36 or 42.00 cm²/m² for males and 3.92 or 38.00 cm²/m² for females, respectively. Cox proportional hazards and Kaplan–Meier (K‐M) analyses were employed to evaluate patient survival.ResultsThe findings indicated that both L3‐PMI and L3‐SMI before TIPS were independent risk factors for mortality. The results of the paired t‐test demonstrated a significant increase in L3‐PMI 1 month post‐TIPS (5.11 ± 1.81 vs. 5.71 ± 1.90 cm²/m², p < 0.001), whereas L3‐SMI did not exhibit a significant increase until 6 months post‐TIPS (45.45 ± 9.41 vs. 48.59 ± 10.38 cm²/m², p < 0.001). Among these patients, 191 (47.0%) and 159 (39.2%) were diagnosed with sarcopenia according to the L3‐PMI and L3‐SMI models, respectively. Patients identified as sarcopenic by both indicators demonstrated a significantly lower survival rate (L3‐SMI model: hazard ratio [HR], 1.913; 95% confidence interval [CI], 1.094–3.410; log‐rank p = 0.020; L3‐PMI model: HR, 1.867; 95% CI, 1.059–3.290; log‐rank p = 0.030). In sarcopenic patients, the reversal of sarcopenia associated with improved survival occurred 1 month after TIPS in the L3‐PMI model (HR, 2.675; 95% CI, 1.245–5.735; log‐rank p = 0.012), while a similar effect was not observed until 6 months post‐TIPS in the L3‐SMI model (HR, 3.342; 95% CI, 1.477–7.560; log‐rank p = 0.004).ConclusionsL3‐PMI and L3‐SMI demonstrate comparable efficacy in diagnosing cirrhosis‐related sarcopenia. Furthermore, L3‐PMI has the capacity to identify improvements in sarcopenia as early as 1 month following TIPS, thereby providing earlier insights into patient survival outcomes.
Synthesis of Ferrocene‐Containing Schiff Bases Based on 3‐Aminopropyltriethoxysilane Oligomers for Covalent Modification of Glass Surfaces and Creation of Soft Magnetic Materials
Authors: Dvorikova Raisa , Markova Galy , Shulgin Anton , Komarova Ludmila , Baranov Oleg , Shchetinin Igor , Bagrov Dmitry , Buzin Mikhail , Klemenkova Zinaida , Mezhuev Yaroslav 
Published: November 2024

ABSTRACTA ferrocene‐containing oligoorganosiloxane with a number‐average degree of polymerization of 8.8 and a number‐average molecular weight of 3200 is synthesized by hydrolytic condensation of 3‐aminopropyltriethoxysilane followed by chemical modification of the resulting oligomer with acetylferrocene. Its structure is characterized by MALDI‐TOF, NMR and IR spectroscopy. 1H NMR spectroscopy shows the predominance of more thermodynamically stable units containing anti‐configuration Schiff bases. Using IR spectroscopy as well as experimental determination of surface energy and its polar (acid–base) and dispersion components, the covalent immobilization of ferrocene‐containing oligoorganosiloxane on a glass surface after heating at 110°C is shown. The formed coating provides hydrophobization, acid–base indifference of the glass surface and serves as a precursor for the formation of magnetically soft materials after pyrolysis in argon already at 350°C. The main stages of ferrocene‐containing oligoorganosiloxane thermal destruction in an inert atmosphere and the formation of a mixture of iron and silicon oxides during its thermal oxidative destruction are established by combination of TGA/DTA, IR spectroscopy and elemental analysis. The proposed approach opens up new possibilities for functionalizing silicates surfaces, creating magnetic glasses, as well as regulating surface energy and its components.
Mental Health of Pediatric Patients with Cystic Fibrosis after 18 Months on Elexacaftor‐Tezacaftor‐Ivacaftor Therapy
Authors: Pasley Kimberly , Eisner Mariah , Sliemers Stephanie , Young Rylie , Dell Mary Lynn , McCoy Karen S. , May Anne 
Published: November 2024

ABSTRACTBackgroundResearch studies are conflicting regarding new highly effective modulators and the association with mental health symptoms for adults and adolescents with cystic fibrosis (CF). For younger children, small studies and case reports indicate a wide range of effects, ranging from improvement in mood to the development of neuropsychiatric symptoms. However, a large placebo‐controlled study indicated no causal connection. This study evaluates the frequency and severity of mental health symptoms in children and adolescents while taking elexacaftor/tezacaftor/ivacaftor (ETI).MethodsThe study includes 81 pediatric patients with CF followed at Nationwide Children's Hospital (NCH). Patient Reported Outcomes Measurement Information System (PROMIS)‐Anxiety and Depression, Patient Health Questionnaire 8 (PHQ‐8) and Generalized Anxiety Disorder Questionnaire (GAD‐7) were used to screen for depression and anxiety. Age‐appropriate questionnaires were completed over the first 18 months after initiating ETI.ResultsAt baseline, majority of participants reported mental health symptoms within normal limits (WNL). For participants with elevated baseline measures, depressive and anxiety symptoms significantly decreased throughout the study period. Depending on the metric, patients experiencing depressive and anxiety symptoms dropped to 2−3% (n = 1, on each depressive measure) and 0% (n = 0, on either anxiety measures) respectively by 18 months.ConclusionMost pediatric patients with CF did not endorse symptoms of depression or anxiety disorders at ETI initiation. Over the first 18 months of ETI usage, the percentage of patients with these symptoms decreased, suggesting that the percentage of patients experiencing severe symptoms of depression and anxiety may decrease with ongoing use of ETI.
Efficacy and utility of isocycloseram a novel isoxazoline insecticide against urban pests and public health disease vectors
Authors: Saran Raj Kumar , Hoppé Mark , Mayor Sarah , Long Catherine , Blakely Brittny , Eppler Lisa , Cartwright Bob , Scherer Clay W. 
Published: November 2024

AbstractBACKGROUNDIsoxazolines inhibit γ‐aminobutyric acid chloride channels in insects and acarids by binding to postsynaptic receptors. This prevents chloride influx, leading to depolarization/hyperexcitation, paralysis, and death. Here, we evaluated the potential utility of a novel isoxazoline, isocycloseram, against several urban insect pests.RESULTSIsocycloseram was active at low doses against the German cockroach, Blattella germanica (L.) [median lethal dose (LD50) 5–15 ng per insect at 72 h, topical assays]; Argentine ant (Linepithema humile Mayr), Pharaoh ant (Monomorium pharaonis (L.), common bed bug (Cimex lectularius (L.) (approximately 40 mg m−2, residual surface spray); Eastern subterranean termite (Reticulitermes flavipes (Kollar) and Formosan subterranean termite (Coptotermes formosanus Shiraki) (5 μg g−1 w/w, tunneling assays); and mosquito, Anopheles stephensi Liston (120 and 150 mg m−2 treated surfaces, aged indoors for 9 months). Additionally, cockroach gel bait at 1% isocycloseram (w/w) caused 95–100% mortality in German, American (Periplaneta americana (L.), and oriental (Blatta orientalis (L.) cockroaches within 5–14 days.CONCLUSIONSIsocycloseram proved to be active against both laboratory and field populations of German cockroaches at doses lower or equal to those of other chemicals. Ants, bed bugs, and mosquitoes readily acquired lethal doses of isocycloseram from different surfaces treated with formulated products. Given its non‐repellent nature, delayed effects, and activity at low rates, isocycloseram can be a very effective compound against subsocial, social, and other human disease vector insect pests. © 2024 Society of Chemical Industry.
DSA‐Former: A Network of Hybrid Variable Structures for Liver and Liver Tumour Segmentation
Authors: Qin Jun , Luo Huizhen , He Fei , Qin Guihe 
Published: November 2024

ABSTRACTBackgroundAccurately annotated CT images of liver tumours can effectively assist doctors in diagnosing and treating liver cancer. However, due to the relatively low density of the liver, its tumours, and surrounding tissues, as well as the existence of multi‐scale problems, accurate automatic segmentation still faces challenges.MethodsWe propose a segmentation network DSA‐Former that combines convolutional kernels and attention. By combining the morphological and edge features of liver tumour images, capture global/local features and key inter‐layer information, and integrate attention mechanisms obtaining detailed information to improve segmentation accuracy.ResultsCompared to other methods, our approach demonstrates significant advantages in evaluation metrics such as the Dice coefficient, IOU, VOE, and HD95. Specifically, we achieve Dice coefficients of 96.8% for liver segmentation and 72.2% for liver tumour segmentation.ConclusionOur method offers enhanced precision in segmenting liver and liver tumour images, laying a robust foundation for liver cancer diagnosis and treatment.
Clinical Relevance of Oxidative Stress Biomarkers in Human Flavivirus Infections as Predictors of Disease Progression and Severity
Authors: Van Herreweghe Maxim , De Bruyne Tess , Hermans Nina , Huits Ralph 
Published: November 2024

ABSTRACTSeveral Flaviviridae constitute an emerging threat to global health because of their continuing spread and the expansion of vector habitats, largely driven by climate change and intensified global travel. Infections can result in severe neurological or visceral pathologies. The relationship between oxidative stress (OS), an imbalance between generated reactive oxygen species and the antioxidant defences of the host, and flavivirus infection has been repeatedly demonstrated in in vitro and animal studies, but measuring biomarkers of oxidative stress in vivo could prove useful in clinical patient management. We summarise the knowledge and prospects of measuring peripheral OS biomarker levels for clinical case management and correlation with disease severity in six important human flavivirus infections (dengue virus (DENV), Japanese encephalitis virus, West Nile virus (WNV), tick‐borne encephalitis virus (TBEV), yellow fever virus and zika virus). We searched the Medline and Web of Science databases for ‘Oxidative Stress’ AND ‘Biomarkers’ AND ‘Flavivirus’, combined with ‘clinical’, ‘in vivo/in vivo’, ‘patient’ and/or ‘disease’ and included 43 peer‐reviewed publications. Correlation between OS and infection has been studied in all six Flaviviridae, but most clinically relevant data are available for DENV, TBEV and WNV. Plasma protein carbonyls, glutathione peroxidase activity and nitrogen monoxide are promising prognostic markers, but their measurement would benefit from methodological harmonisation. Future studies should investigate a broad range of OS biomarkers as predictors of clinically relevant outcomes. We advocate the validation and use of universal or disease‐specific oxidative stress indexes that incorporate the most significant outcomes into one, easy‐to‐use clinical determinant.
Disturbance Observer‐Based Neural Adaptive Command Filtered BacksStepping Funnel‐Like Control for the Chaotic PMSM With Asymmetric Prescribed Performance Constraints
Authors: Li Shaoyang , Zhang Junxing , Li Menghan , Wu Fengbin , Zhou Peng 
Published: November 2024

ABSTRACTThis paper suggests a neural adaptive command filtered backstepping tracking control strategy for the chaotic permanent magnet synchronous motors with asymmetric prescribed performance constraints. Therefore, enable chaotic permanent magnet synchronous motors (PMSM) to obtain good robustness and better universality in practical industrial environments, and realizes more accurate control effect. The main challenge lies in devising a valid funnel‐like solution within the backstepping frame to handle the asymmetric performance constraints that traditional solutions cannot solve. To achieve this, a novel funnel‐like function is introduced, integrating a performance boundary function independent of initial output error, thereby transforming the system into an unbounded one. Additionally, the “explosion of complexity” with conventional backstepping is mitigated by introducing command filtering and constructing an error compensating system to reduce errors. By combining the theory of Lyapunov function and backstepping technique, the virtual controller and the real controller with adaptive law ensure the stability of the system. The disturbance observer and neural network solve the external disturbance and the uncertain nonlinear problem, respectively. Simulation comparisons confirm the robustness of the proposed control scheme and demonstrate its superiority over existing solutions.
The Good Cops, Bad Cops, Bullets, and Wounds: Toward Culturally Sustaining Prison Abolition Literacies in Early Childhood Education
Authors: McMillan Rachel , Bryan Nathaniel 
Published: November 2024

AbstractDominant discourses on the prison industrial complex/ mass incarceration tend to prioritize the experiences of Black adults. However, Black children are dual victims of the prison industrial complex. By that, we mean that they are subjected to incarceration in and beyond early childhood education, and the negative impact of the incarceration of parents/caregivers and other family members. With such considerations in mind, early childhood teachers should teach young Black children to become aware of the injustices of the prison industrial complex. To that end, we ask the following question: How can teachers raise Black children's consciousness of the prison industrial complex and encourage them to build a longstanding commitment to dismantle it through early literacy practices? In this conceptual article, we draw on culturally sustaining pedagogy, the imprisoned Black radical tradition, and abolitionist teaching to introduce and explain the utility of culturally sustaining prison abolition literacies—a literacy practice that acknowledges the pervasive injustices of the carceral state and action‐oriented ways to combat them to protect Black children and other minoritized children—in early childhood teaching and curriculum.
Soil quality index to access the impacts of long‐term vinasse application in sugarcane areas
Authors: Coelho Anderson Prates , Tassim Isis Albuquerque , Orioli Yasmin Uchino , Fernandes Mariele Monique Honorato , Cardoso Edmilson N'dami Lopes , Fernandes Carolina 
Published: November 2024

AbstractSoil quality index (SQI) helps quantify management practices impacts on the soil, providing information for producers in decision‐making. Through evaluation in sugarcane areas, soil indicators were used to develop SQI to access and quantify the impacts of long‐term vinasse application on the soil. The treatments consisted of two soil types: clayey (490 g kg−1 clay) and sandy (80 g kg−1 clay) and two conditions: with (70 m3 ha−1 year−1) and without vinasse application for 10 years. Soil samples were collected in the 0‐ to 10‐cm, 10‐ to 20‐cm, and 20‐ to 30‐cm layers in each treatment. Four soil functions were developed to calculate SQI: root environment quality (REQ), air/water ratio (AWR), soil chemical quality (SCQ), and soil tolerance to erosion (STE). Twelve soil indicators related to soil fertility and aggregation/structure were used. The long‐term vinasse application increased water storage (32%–58% of soil porosity), sum of bases (11–19 mmolc dm−3) and aggregate stability index (41% vs. 78%) compared to without vinasse treatment in sandy soil. In the clayey soil, vinasse increased (p < 0.05) the REQ, SCQ, and STE functions by 10%, 14%, and 13%, respectively, besides not affecting AWR. The long‐term application of vinasse promoted greater benefits, proportionally, in the sandy soil, with increments (p < 0.05) of 30% in AWR, 25% in SCQ, and 27% in STE. According to the SQI, long‐term vinasse application increased the capacity of the clay soil to perform its functions by 8%, while it increased to the sandy soil was 22%.
Teacher Guidance and On‐the‐Fly Scaffolding in Primary School Students' Inquiry Learning
Authors: Sasse Heide , Weber Anke M. , Reuter Timo , Leuchter Miriam 
Published: November 2024

ABSTRACTIn primary science education, inquiry‐based science instruction stands out as an optimal learning environment for fostering domain‐specific content and procedural knowledge. Recognizing the effectiveness of different forms of teacher guidance, there is an ongoing debate about the planning of high (structured inquiry) and low (guided inquiry) guidance and their optimal sequencing. This debate revolves around balancing the level of autonomy and the amount of conceptual information given to students. Furthermore, the complete understanding of the impact of responsive teaching, which encompasses a broad range of practices, including on‐the‐fly scaffolding such as Promoting Participation, Focusing, and Problematizing, remains elusive. To address this gap, this study examines the relationship between planned teacher guidance and specific instances of responsive teaching, particularly on‐the‐fly scaffolding in the inquiry‐based science classroom. A pre‐posttest design was employed, involving 164 primary school students (M = 9.9 years, SD = 0.66, 57% female) and one female experimenter. Domain‐specific content knowledge contained science concepts of thermal insulation, whereas procedural knowledge comprised the application of the control‐of‐variables strategy. The sequential order of planned teacher guidance, structured inquiry, and guided inquiry, was systematically varied, and the experimenter was allowed to provide spontaneous on‐the‐fly scaffolding. The study assesses the influence of planned teacher guidance and specific instances of responsive teaching, particularly on‐the‐fly scaffolding on students' conceptual and procedural knowledge. Results indicate no differential learning effects based on the order of planned guidance. However, when planned guided inquiry was provided second, the teacher gave less on‐the‐fly scaffolding. Additionally, Problematizing had a positive effect, while Focusing had a negative effect on students' procedural knowledge learning.