bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating asthma care guidelines into primary care electronic medical records: a review focused on Canadian knowledge translation tools
Authors: McFarlane Matheson , Morra Alison , Lougheed M. Diane 
Published: November 2024

IntroductionAsthma is one of the most common chronic respiratory diseases globally. Despite national and international asthma care guidelines, gaps persist in primary care. Knowledge translation (KT) electronic tools (eTools) exist aiming to address these gaps, but their impact on practice patterns and patient outcomes is variable. We aimed to conduct a nonsystematic review of the literature for key asthma care gaps and identify limitations and future directions of KT eTools optimised for use in electronic medical records (EMRs).MethodsThe database OVID Medline was searched (1999–2024) using keywords such as asthma, KT, primary healthcare and EMRs. Primary research articles, systematic reviews and published international/national guidelines were included. Findings were interpreted within the knowledge-to-action framework.ResultsKey asthma care gaps in primary care include under-recognition of suboptimal control, underutilisation of pulmonary function tests, barriers to care delivery, provider attitudes/beliefs, limited access to asthma education and referral to asthma specialists. Various KT eTools have been validated, many with optimisation for use in EMRs. KT eTools within EMRs have been a recent focus, including asthma management systems, decision support algorithms, data standards initiatives and asthma case definition validation for EMRs.ConclusionsThe knowledge-to-action cycle is a valuable framework for developing and implementing novel KT tools. Future research should integrate end-users into the process of KT tool development to improve the perceived utility of these tools. Additionally, the priorities of primary care physicians should be considered in future KT tool research to improve end-user uptake and overall asthma management practices.
TikTok and frozen shoulder: a cross-sectional study of social media content quality
Authors: D’Ambrosi Riccardo , Bellato Enrico , Bullitta Gianluca , Cecere Antonio Benedetto , Corona Katia , De Crescenzo Angelo , Fogliata Valentina , Micheloni Gian Mario , Saccomanno Maristella Francesca , Vitullo Fabrizio , Celli Andrea ,   SICSeG (Italian Society of Shoulder, Elbow Surgery) Research Committee
Published: November 2024

Abstract
Purpose
This study aimed to assess the validity and informational value of the material provided on TikTok regarding frozen shoulders. The hypothesis was that the video content on this platform would not provide adequate and valid information.

Methods
The current study focused on frozen shoulder videos on the TikTok social media platform. The terms “frozen shoulder” and/or “adhesive capsulitis” were used as keywords for an extensive online search of video content on TikTok, and the first 100 videos were included. Out-of-topic, non-English, and duplicated videos were excluded from the analysis. The duration and numbers of likes, shares, and views were recorded for each video. Further, videos were categorized based on the source (physiotherapist/osteopath, medical doctor, or private user), type of information (physical therapy, etiopathogenesis, anatomy, clinical examination, patient experience, or symptoms), video content (rehabilitation, education, or patient experience/testimony), and the presence of music or a voice. The assessment of the video content’s quality and reliability was performed by two experienced shoulder surgeons using the DISCERN instrument, the Journal of the American Medical Association (JAMA) benchmark criteria, and the Global Quality Score (GQS).

Results
A total of 100 videos were included in the analysis, of which 86 (86.0%) were published by physiotherapists/osteopaths. Most of the information and video content focused on physical therapy and rehabilitation (83.0% and 84.0%, respectively). Eighty-four (84.0%) videos included voice comments, while the remaining featured music. The mean number of views was 2,142,215.32 ± 6,148,794.63, while the mean numbers of likes, comments, and shares were 58,438.67 ± 201,863.54, 550.81 ± 1712.22, and 3327.43 ± 7320.81, respectively. The mean video duration was 110.20 ± 116.43 s. The mean DISCERN score, JAMA score, and GQS were 16.17 ± 2.36, 0.61 ± 0.51, and 1.18 ± 0.41, respectively. Videos posted by medical doctors or private users received higher scores than those posted by physiotherapists/osteopaths (p < 0.05).

Conclusions
The educational value of videos published on TikTok was poor; videos posted by medical doctors exhibited better quality and educational value than those of physiotherapists or osteopaths. It is the responsibility of orthopedic surgeons to investigate the potential benefits, consequences, and implications of TikTok video content for the health of frozen shoulder patients and to propose necessary adjustments. Given the rapid growth of TikTok, further research is needed.

Level of evidence

Level IV—cross-sectional study.
Association of serum uromodulin with diabetic kidney disease: a systematic review and meta-analysis
Authors: Barr Shaimaa I. , Abd El-Azeem Eman M. , Bessa Sahar S. , Mohamed Tarek M. 
Published: November 2024

Abstract
Background
Several studies have investigated the association between the changes of serum uromodulin and diabetic kidney disease (DKD). However, the results are still controversial. Therefore, this meta-analysis was conducted to provide a comprehensive evaluation of the association between serum uromodulin levels and DKD.

Methods
PubMed, Cochrane library, Web of Science, and Scopus were systemically searched following the PRISMA protocol to identify the studies that reported the relationship between serum uromodulin level and DKD. To investigate the association between uromodulin and DKD, a standardized mean difference (SMD) with a 95% confidence interval (CI) was used. When significant heterogeneity was detected (I2 > 50%), sensitivity and subgroup analyses were performed to determine the source of heterogeneity. The quality assessment was determined using the Newcastle-Ottawa scale (NOS), and the publications bias were determined by the funnel plot and Egger’s test.

Results
In total, 6 studies with 1774 patients were included in the final analysis. The random effect model was used. The pooled results showed that the serum uromodulin levels were significantly decreased in patients with DKD (SMD: -0.31; 95% CI: -0.48 to -0.13) (I2 = 45%). Upon applying the sensitivity analysis, it showed (SMD: -0.38; 95% CI: -0.49 to -0.27) (I2 = 3%). Subgroup analysis showed that uromodulin level was significantly decreased in DKD regardless of the region of study, in America (SMD: -0.34; 95% CI: -0.51 to -0.17; p < 0.0001), Europe (SMD: -0.54; 95% CI: -1.06 to -0.02; p = 0.04), and Asia (SMD: -0.63; 95% CI: -1.15 to -0.11; p = 0.02), with stronger predictive value in America and Asia than in Europe. Additionally, uromodulin levels were significantly decreased in both type 1 (SMD: -0.34; 95% CI: -0.51 to -0.17; p < 0.0001) and type 2 diabetes (SMD: -0.58; 95% CI: -0.95 to -0.22; p = 0.002).

Conclusion
This meta-analysis showed a significant association between low levels of serum uromodulin and DKD. So, it could have a predictive role for DKD. However, its performance varied across subgroup analyses restricted by race and clinical settings. Moreover, further studies are required with a focus on the cut-off value for predicting diagnostic accuracy.
Detection of human enteric viral genes in a non-native winter crane fly, Trichocera maculipennis (Diptera) in the sewage treatment facilities at Antarctic stations
Authors: Lee Sook-Young , Kim Ji Hee , Kang Seunghyun , Park Kye Chung , Cho Sung Mi , Salinas Carla Ximena , Rebolledo Lorena , Benítez Hugo A. , Mejías Tamara Contador , Soutullo Alvaro , Juri Eduardo , Kim Sanghee 
Published: November 2024

Abstract
Background
The Antarctic environment is susceptible to the introduction of non-native species due to its unique ecosystem, which has evolved under geographical isolation and extreme climatic conditions over an extended period. The recent introduction of the non-native winter crane fly, Trichocera maculipennis, to maritime Antarctica may pose a potential threat to the Antarctic ecosystem. In this study, we evaluated the possibility of the mechanical transmission of viruses by T. maculipennis.

Methods
We assessed the potential for the mechanical transmission of viruses using next-generation sequencing (NGS), quantitative PCR (qPCR), and virus isolation methods from T. maculipennis (Tm)-related samples (Tm body-wash fluid and Tm body-ground samples) collected from habitats and sewage treatment facilities located at three research stations in Antarctica.

Results
Virome analysis detected the genomic fragments of human adenovirus (AdV) and human endogenous retrovirus (HERV) in Tm-related samples. These viruses are commonly found in human feces. In addition, plant viruses, such as pepper mild mottle virus (PMMoV) and cucumber green mottle mosaic virus (CGMMV), both known indicators of enteric viruses, were identified in all Tm-related samples, likely originating from wastewater. However, the low quantities of AdV and HERV genomes detected in Tm-related samples through qPCR, coupled with the non-viability of AdV in virus isolation tests, indicate that T. maculipennis has limited potential for mechanical transmission under the conditions in the studies.

Conclusions
Our study represents the first evaluation of the potential risk of non-native species serving as vectors for viral pathogens in Antarctica. Although the viruses detected were in relatively low quantities and non-viable, this study highlights the importance of further evaluating the risks associated with non-native species, particularly as the likelihood of their introduction increases to Antarctica due to climate change and increased human activity.

Graphical abstract
Thelazia leesei Railliet & Henry, 1910 (Spirurida: Thelaziidae) of dromedary camel Camelus dromedarius: further morphological description, molecular characterization, and epidemiology in Iran
Authors: Khedri Javad , Sazmand Alireza , Sadr Soheil , Said Mourad Ben , Uni Shigehiko , Otranto Domenico , Borji Hassan 
Published: November 2024

Abstract
Background
In camels, thelaziosis is mainly caused by Thelazia leesei Railliet & Henry, 1910, a little-known eyeworm species. Given the paucity of scientific data, this study aimed to provide new insights into the morphology, molecular characterization, and phylogenetic relationship of T. leesei and its occurrence in camels from Iran, where animals suffer from the high burden of eyeworms.

Methods
From December 2020 to November 2022, slaughtered camels (n = 400) of different sex and age groups were examined in Sistan-va-Baluchestan province in Southeast Iran’s local abattoirs. Adult eyeworms were fixed and stored for morphological identification by light and scanning electron microscopy (SEM). Polymerase chain reaction (PCR) products corresponding to the partial sequences of the mitochondrial cytochrome c oxidase subunit I (cox1) of eyeworms were Sanger sequenced and analyzed phylogenetically.

Results
A total of 118 (29.5%) camels from all five counties examined were infected with eyeworms, with an abundance of 0.9 and a mean intensity of 3.2 (i.e., up to 18 worms from a single animal). The infection rate was higher in camels older than 4 years of age (P = 0.01901). Lachrymation was associated with infection in animals (P < 0.00001). The morphology of our specimens resembled that of T. leesei, with the exception of the position of the nerve ring and esophagus length. Genetic analysis showed that the cox1 partial sequences of our T. leesei specimens had genetic distances of 8.8% to 13.5% compared with other Thelazia species.

Conclusions
On the basis of the morphometrics and morphological characteristics, we identified our specimens as T. leesei. In the phylogenetic tree, T. leesei herein isolated formed a monophyletic group together with its congeners, and T. leesei formed a sister clade to T. lacrymalis. In addition, we demonstrated the epidemiology of the infestation of T. leesei in camels in the endemic areas of southeastern Iran. The data presented are crucial for better understanding the pathogenic role of T. leesei and developing effective treatment strategies. In particular, studies on the intermediate host(s) of T. leesei in these regions will support effective control strategies for this parasitosis.

Graphical Abstract
Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes
Authors: Tran Duc Tin , Yeung Emily S. H. , Hong Lisa Y. Q. , Kaur Harmandeep , Advani Suzanne L. , Liu Youan , Syeda Madiha Zahra , Batchu Sri Nagarjun , Advani Andrew 
Published: November 2024

Abstract
Background
Several new treatments have recently been shown to have heart and kidney protective benefits in people with diabetes. Because these treatments were developed in parallel, it is unclear how the different molecular pathways affected by the therapies may overlap. Here, we examined the effects of the mineralocorticoid receptor antagonist finerenone in mice with comorbid diabetes, focusing on the regulation of expression of the glucagon-like peptide-1 receptor (GLP-1R), gastric inhibitory polypeptide receptor (GIPR) and glucagon receptor (GCGR), which are targets of approved or investigational therapies in diabetes.

Methods
Male C57BL/6J mice were fed a high fat diet for 26 weeks. Twelve weeks into the high fat diet feeding period, mice received an intraperitoneal injection of streptozotocin before being followed for the remaining 14 weeks (DMHFD mice). After 26 weeks, mice were fed a high fat diet containing finerenone (100 mg/kg diet) or high fat diet alone for a further 2 weeks. Cell culture experiments were performed in primary vascular smooth muscle cells (VSMCs), NRK-49 F fibroblasts, HK-2 cells, and MDCK cells.

Results
DMHFD mice developed albuminuria, glomerular mesangial expansion, and diastolic dysfunction (decreased E/A ratio). Glp1r and Gcgr were predominantly expressed in arteriolar VSMCs and distal nephron structures of mouse kidneys respectively, whereas Gipr was the predominant of the three transcripts in mouse hearts. Kidney Glp1r and Gcgr and cardiac Gipr mRNA levels were reduced in DMHFD mice and this reduction was negated or attenuated with finerenone. Mechanistically, finerenone attenuated upregulation of the profibrotic growth factor Ccn2 in DMHFD kidneys, whereas recombinant CCN2 downregulated Glp1r and Gcgr in VSMCs and MDCK cells respectively.

Conclusions
Through its anti-fibrotic actions, finerenone reverses Glp1r and Gcgr downregulation in the diabetic kidney. Both finerenone and GLP-1R agonists have proven cardiorenal benefits, whereas receptor co-agonists are approved or under development. The current findings provide preclinical rationale for the combined use of finerenone with the GLP-1R agonist family. They also provide mechanism of action insights into the potential benefit of finerenone in people with diabetes for whom GLP-1R agonists or co-agonists may not be indicated.
New Odonatan oviposition ichnotaxa from the Lower Jurassic of Iran
Authors: Hashemi Hossein , Sadeghi Solmaz , Wappler Torsten 
Published: November 2024

AbstractDistinct, new oviposition lesion types, Paleoovoidus pyriformis ichnosp. nov. and Variomorphonotatus sagittaeformis ichnogen. et ichnosp. nov., occurring on two fossil compression Cycadophyte leaves from the Lower Jurassic Shemshak Formation of western Alborz Ranges, northern Iran are documented and compared with the previously instituted morphologically analogous taxa. Comparison of the shape and configuration of the scars with those of the modern zygopteran Odonata suggests that any member of the Lestid-damselfly produced P. pyriformis ichnosp. nov. whereas any representative of Coenagrionid-damselflies (damselflies-dragonflies) induced formation of V. sagittaeformis ichnogen. et ichnosp. nov. In the absence, so far, of any entomofaunal evidence from the Shemshak Formation, the ichnotaxa documented herein offer unequivocal evidence to the presence of the Odonatan representatives in the Early Jurassic riparian ecosystems of northern Iran.
Intracranial pressure trends and clinical outcomes after decompressive hemicraniectomy in malignant middle cerebral artery infarction
Authors: Jung Jae Wook , Kang Ilmo , Park Jin , Lee Seungjoo , Jeon Sang-Beom 
Published: November 2024

Abstract
Background
Malignant middle cerebral artery infarction (MMI) is associated with a high incidence of severe disability and mortality. Decompressive hemicraniectomy has become a recognized treatment that can improve the prognosis for patients if performed within a certain time window. Nevertheless, despite this intervention, a mortality rate of approximately 20–40% persists following the surgery. The trends and clinical implications of intracranial pressure (ICP) in these situations remain unclear. We aimed to investigate whether intracranial pressure (ICP) trends are associated with clinical outcomes in patients undergoing decompressive hemicraniectomy for MMI.

Methods
This retrospective cohort study included consecutive patients with MMI who underwent decompressive craniectomy and received ICP monitoring after surgery. Using a linear mixed model, we categorized the patients into ICP increase and decrease groups based on the ICP values obtained over 192 h. We then compared the proportion of 3-month favorable outcomes (modified Rankin Scale of 0−4) and mortality rates between these groups.

Results
Of 112 MMI patients who underwent decompressive hemicraniectomy, 66 (58.9%) received invasive ICP monitoring. ICP monitoring was performed for a median of 146.5 h (IQR 72.5–181.8). Among the 66 patients, 37 (56.1%) were in the ICP increase group, and 29 (43.9%) were in the ICP decrease group. During the monitoring period, the initial monitored ICP and peak ICP did not significantly differ between the ICP increase and decrease groups. However, the ICP trend was significantly different between the two groups (P < 0.001). In multivariable logistic regression analyses, the ICP increase group had a significantly lower proportion of 3-month favorable outcomes compared to the ICP decrease group (adjusted OR 0.11; 95% CI, 0.01–0.59; P = 0.019), and significantly higher mortality in the intensive care unit (adjusted OR 6.98; 95% CI, 1.37–54.6; P = 0.031).

Conclusions
In MMI patients, continuous ICP monitoring could be useful for detecting those with an increasing ICP trend that may be associated with unfavorable clinical outcomes.
You say it‘s not me: the influence of offering external explanations of rejection and acceptance behavior on the perception of benevolence in borderline personality disorder
Authors: Schulze Anna , Rommelfanger Berit , Schendel Elisabeth , Kammler-Sücker Kornelius Immanuel , Lis Stefanie 
Published: November 2024

Abstract
Background
Interpersonal impairments in patients diagnosed with borderline personality disorder (BPD) are characterized by the fear of being rejected and high levels of loneliness. Potential underlying factors are alterations in the processing of social interactions and the associated perceptions of social partners. In this regard, BPD patients tend to attribute the cause of negative rather than positive events to their own person and to perceive others as less trustworthy than healthy controls (HCs). To date, no study has investigated whether the effect of experimentally influenced causal attributions of social interactions on the perception of a social partner differs between BPD patients and HCs.

Methods
A new virtual reality paradigm was developed to investigate the perception of benevolence following the induction of social rejection and acceptance, while experimentally manipulating whether an external cause for this behavior was provided. The data of 62 participants (32 HCs, 30 BPD patients) were analyzed using linear mixed-effects models. Associations of benevolence ratings with attributional style, rejection sensitivity, self-esteem, childhood trauma, and loneliness were investigated via correlational and multiple linear regression analyses.

Results
Across both groups, a social partner was rated as less benevolent following rejection than following acceptance. An external explanation mitigated this negative effect of rejection. Overall, benevolence ratings were lower in BPD patients than in HCs. This group difference was stronger following acceptance than following rejection. Independent of acceptance and rejection, an external explanation was associated with a higher level of benevolence only in the HC group. No associations of the effects of the experimental conditions with attributional style, childhood trauma, rejection sensitivity, self-esteem, or loneliness were found.

Conclusion
Our findings indicate that acceptance and provided external explanations for rejection have a less positive impact on the perception of a social partner’s attitude toward oneself in BPD patients than in HCs. More research is needed to identify predictors of benevolence perception and which steps of social information processing are altered. The therapeutic implications include the importance of strengthening the perception and enjoyment of being accepted as well as improving the mentalizing ability of BPD patients.
Skeletal Effects of Sleeve Gastrectomy, by Sex and Menopausal Status and Compared to Roux-En-Y Gastric Bypass Surgery
Authors: Wu Karin C , Wu Po-Hung , Kazakia Galateia , Patel Sheena , Black Dennis M , Lang Thomas F , Kim Tiffany Y , King Nicole J , Hoffmann Thomas J , Chang Hanling , Linfield Gaia , Palilla Sarah , Rogers Stanley J , Carter Jonathan T , Posselt Andrew M , Schafer Anne L 
Published: November 2024

Abstract

Context
Roux-en-Y gastric bypass (RYGB) has deleterious effects on bone mass, microarchitecture, and strength. The skeletal effects of sleeve gastrectomy (SG), now the most commonly performed bariatric surgical procedure, are incompletely understood.

Objective
We examined changes in bone turnover, areal bone mineral density (aBMD) and volumetric bone mineral density (vBMD), and appendicular bone microarchitecture and estimated strength after SG. We compared the results to those previously reported after RYGB, hypothesizing lesser effects after SG than RYGB.

Design, Setting, Participants
Prospective observational cohort study of 54 adults with obesity undergoing SG at an academic center.

Main Outcome Measures
Skeletal characterization with biochemical markers of bone turnover, dual-energy X-ray absorptiometry, quantitative computed tomography, and high-resolution peripheral QCT was performed preoperatively and 6 and 12 months postoperatively.

Results
Over 12 months, the mean percentage weight loss was 28.8%. Bone turnover marker levels increased, and total hip aBMD decreased −8.0% (95% CI −9.1%, −6.7%, P &lt; 0.01). Spinal aBMD and vBMD declines were larger in postmenopausal women than men. Tibial and radial trabecular and cortical microstructure worsened, as did tibial estimated strength, particularly in postmenopausal women. When compared to data from a RYGB cohort with identical design and measurements, some SG biochemical, vBMD, and radial microstructural changes were smaller, while other changes were not.

Conclusion
Bone mass, microstructure, and strength decrease after SG. Some skeletal parameters change less after SG than after RYGB, while for others we find no evidence for smaller effects after SG. Postmenopausal women may be at the highest risk of skeletal consequences after SG.