bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of a new product based on quercetin and a thick extract of carrot seed root on the histological state of the rat cardiac muscle in the adrenaline-hydrocortisone-induced myocardial infarction
Authors: Kononenko T. R. , Chikitkina V. V. 
Published: November 2024

Aim. To study the effect of tablets with a thick extract of carrot seed root and quercetin on the histological state of the rat cardiac muscle in the experimental adrenaline-hydrocortisone-induced myocardial infarction.
Materials and methods. The cardioprotective effect of tablets with a thick extract of carrot seed root and quercetin was studied on the model of acute adrenaline-hydrocortisone-induced myocardial infarction caused by subcutaneous administration of 0.1 % adrenaline hydrochloride solution in the dose of 1 mg/kg and 2.5 % hydrocortisone acetate emulsion in the dose of 12.5 mg/kg of the animal weight twice daily for a week. The tablets under research in the dose of 200 mg/kg and the reference drugs – “Thiotriazolin” and “Cratal” tablets were administered for 14 days – 7 days before the infarction modeling and 7 days of the myocardial infarction development, after which their effect on the histological state of the rat heart muscle was studied.
Results. Modeling of the adrenaline-hydrocortisone-induced myocardial infarction in rats is accompanied by the appearance of focal necrotic changes in muscle cells, which in some cases are accompanied by initial regenerative manifestations in the form of granuloma formation; dystrophic processes of cardiomyocytes. The therapeutic and prophylactic administration of tablets from a thick extract of carrot seed root and quercetin on the model of the adrenaline-hydrocortisone-induced myocardial infarction has the cardioprotective effect, reducing the severity of necrotic and dystrophic changes in the cardiac muscle.
Conclusions. As a result of modeling of the adrenaline-hydrocortisone-induced myocardial infarction in rats, focal necrotic changes in muscle cells were observed, sometimes accompanied by the initial formation of a matrix consisting of young fibroblasts; dystrophic processes of cardiomyocytes, in particular myocytolysis, fluctuations in the size of nuclei. The therapeutic and preventive administration of the tablets studied on the model of the adrenaline-hydrocortisone-induced myocardial infarction has the cardioprotective effect, reduces the severity of necrotic and dystrophic changes in the cardiac muscle. By the cardioprotective effect expressiveness, tablets with a thick extract of carrot seed root and quercetin on the model of the adrenaline-hydrocortisone-induced myocardial infarction are not inferior to the reference drugs – “Thiotriazolin” and “Cratal” tablets. The results experimentally substantiate the feasibility of creating a new combined drug from a thick extract of carrot seed root and quercetin for the prevention and pharmacocorrection of a cardiovascular pathology.
Analysis of Tetrachiral Sandwich Structures at High-Velocity Impact: Influence of the Applied Material and Projectile Core Geometry
Authors: Maulana Sultan , Prabowo Aditya Rio , Wibowo Wibowo , Do Quang Thang , Muttaqie Teguh , Muhayat Nurul , Fitri Siti Nurlita 
Published: November 2024

This research involved ballistic impact analysis on a tetrachiral sandwich structure in which the shapes of the circular nodes in the tetrachiral core are modified into polygonal shapes, namely a square, hexagon, and octagon. The objectives of this study were to observe the effect of a modified sandwich tetrachiral structure core, investigate the effect of the projectile geometry, and calculate the material performance of the structure. This research was conducted using numerical analysis utilizing the finite element method. The simulation methodology was validated through a benchmarking study, the results of which showed an error below 6%. The findings show that the material with the best performance was Armox 500T, at 5033 J. The most difficult projectile to withstand was conical, followed by ogive, hemispherical, and blunt. The results of the core modification on the tetrachiral sandwich structure show that the octagonal core had better energy absorption, by 2.8%, compared to the circular core. Modifying the node geometry in the tetrachiral core and then analyzing it with stress and strain contours are the novel aspects of this research. Doi: 10.28991/CEJ-2024-010-10-017 Full Text: PDF
Survive and Thrive in the Time of Changes: A Bibliometric Review of Teacher Resilience, 1998–2023
Authors: Li Xinlin , Chen Junjun 
Published: November 2024

Teacher resilience literature has expanded rapidly with a large number of publications and an evolving knowledge base. To capture a synthetic account systematically and effectively, this review provides a bibliometric approach to quantitatively examine the metadata of 692 relevant publications during the 26 years from 1998 to 2023. The finding traces the field’s progression from an initial concern for at-risk children to early conceptual discussions of resilience and, ultimately, more in-depth theoretical, empirical, and experimental investigations of teacher resilience, particularly within specific contexts like language teaching. However, the future trajectory of this domain remains an open question. The bibliometric review also enabled the researchers to anchor future research directions and contemplate the key challenges, such as the need for more international collaborations, concerted efforts to study teacher resilience across varied contexts, and the need to carefully balance productivity and influence when conducting new studies. Overall, this review aims to spark thoughtful discussions among researchers, practitioners, and policymakers regarding teacher resilience, in order to establish a more sustainable and global knowledge base.
TOWARDS AN INTEGRATION OF DIFFERENT SPECIFICATION METHODS BY USING	THE VIEWPOINT FRAMEWORK
Authors: Enders Bettina E. , Heverhagen Torsten , Goedicke Michael , Tröpfner Peter , Tracht Rudolf 
Published: November 2024

In industrial interdisciplinary projects where engineers of different sorts have to work together, a framework is necessary in order to support such an interdisciplinary development process. For example, the design information created by the production automation engineer has to be set into relation to the software architecture the software designer has to produce which will control the automation plant. Such requirements result in the need to consistently integrate various specification methods and development processes performed during the various development stages. This contribution shows that such an integration of heterogeneous specification methods concerning the various heterogeneous components of production automation systems can be achieved using the ViewPoint framework. This framework provides an intuitive understanding of different specifications involved in the development process, on the one side. On the other side the ViewPoint framework allows for a consistent and correct integration of these specifications due to its existing formalization by distributed graph transformation.
Co-application of sheep manure and commercial organic fertilizer enhances plant productivity and soil quality in alpine mining areas
Authors: Yu Zhongyang , Yao Xixi , Yang Mingchun , Hu Shengbin , An Xiaoting , Li Changhui 
Published: November 2024

Background and aimsThe addition of organic fertilizers and sheep slat manure have important effects on soil quality in alpine mining areas, but how they affect soil physicochemical properties and microorganisms is not yet known.MethodsThe current study employed field-controlled experiments and high-throughput sequencing technology to investigate differences in soil physicochemical properties, microbial community structures, and diversity under four treatments: no fertilization (CK), 100% sheep manure (SM), a combination of 50% sheep manure and 50% commercial organic fertilizer (MF), and 100% commercial organic fertilizer (OF).ResultsAboveground biomass increased by 191.93, 253.22, and 133.32% under SM, MF and OF treatments, respectively, when compared to CK treatment. The MF treatment resulted in significantly higher soil total nitrogen, total phosphorus, organic matter, and available nitrogen content compared to other treatments. Soil total nitrogen content, total phosphorus content, organic matter, available nitrogen content and available phosphorus content were 211, 120, 380, 557, and 271% higher, respectively, under the MF treatment than the CK treatment. Different nutrient additions significantly influenced soil microbial community composition. The SM and MF treatments notably increased soil bacterial and fungal community Operational Taxonomic Units (OTUs) indices and Chao 1 indices, while nutrient addition had no meaningful effect on the Simpson indices for microbial communities. There was a highly significant positive correlation between aboveground biomass and observed soil nutrient content.ConclusionThe combined application of sheep manure and commercial organic fertilizer is more conducive to improving soil quality and enhancing plant productivity in alpine mining areas.
Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells
Authors: Madsen Helena Borland , Navarro Claudia , Gasparini Emilie , Park Jae-Hyeon , Li Zhiquan , Croteau Deborah L. , Bohr Vilhelm A. 
Published: November 2024

IntroductionDuring aging, many cellular processes, such as autophagic clearance, DNA repair, mitochondrial health, metabolism, nicotinamide adenine dinucleotide (NAD+) levels, and immunological responses, become compromised. Urolithin A (UA) and Nicotinamide Riboside (NR) are two naturally occurring compounds known for their anti-inflammatory and mitochondrial protective properties, yet the effects of these natural substances on microglia cells have not been thoroughly investigated. As both UA and NR are considered safe dietary supplements, it is equally important to understand their function in normal cells and in disease states.MethodsThis study investigates the effects of UA and NR on immune signaling, mitochondrial function, and microglial activity in a human microglial cell line (HMC3).ResultsBoth UA and NR were shown to reduce DNA damage-induced cellular senescence. However, they differentially regulated gene expression related to neuroinflammation, with UA enhancing cGAS-STING pathway activation and NR displaying broader anti-inflammatory effects. Furthermore, UA and NR differently influenced mitochondrial dynamics, with both compounds improving mitochondrial respiration but exhibiting distinct effects on production of reactive oxygen species and glycolytic function.DiscussionThese findings underscore the potential of UA and NR as therapeutic agents in managing neuroinflammation and mitochondrial dysfunction in neurodegenerative diseases.
Impact of a brief series of soccer matches on vascular conditions in youth women
Authors: Sugawara Jun , Ogoh Nana , Watanabe Hironori , Saito Shotaro , Ohsuga Maki , Hasegawa Tetsuya , Kunimatsu Narumi , Ogoh Shigehiko 
Published: November 2024

BackgroundAccumulative excessive physical load elevates central arterial stiffness and smooth muscular tone of peripheral vascular beds in endurance athletes. The aim of this study was to test the hypothesis that a brief series of soccer matches would increase central arterial stiffness and arterial wave reflection from the periphery in young female football players.MethodsFifteen subjects (17.2 ± 0.7 years, mean ± SD) participated in four matches over five consecutive days (one match per day, with two consecutive days of matches followed by one rest day, repeated twice) in the Youth Girls Soccer Tournament, either as starters or substitutes. Heart rate, blood pressure (BP), and the second derivative of the photoplethysmogram (SDPTG) were assessed the night before and 4 h after each match. The ratios of the first and second descending waves to the first ascending wave of SDPTG (B/A ratio and D/A ratio) were calculated as indices of central arterial stiffness and peripheral wave reflection, respectively. The intra-individual relationship among interest variables was evaluated using the repeated-measures correlation analysis (rmcorr).ResultsPost-match D/A ratio, systolic and diastolic BP were lower compared to the pre-match value, while the B/A ratio did not change significantly. Heart rate was higher post-than pre-match. Rmcorr demonstrated significant intra-individual correlations of the D/A ratio with diastolic BP (rrm = 0.259, P = 0.008) and heart rate (rrm = −0.380, P&lt; 0.001).ConclusionContrary to our hypothesis, a brief series of matches did not increase central arterial stiffness in young female football players. Instead, the matches induced a repeated, temporary attenuation of arterial wave reflection. This attenuated arterial wave reflection from the periphery appeared to be associated with reduced diastolic BP and a compensatory increase in heart rate.
Enhanced efficacy of Magnolia denudata essential oil in fish anesthesia using nanoemulsions and self-microemulsifying drug delivery systems
Authors: Zeng Xiangbing , Dong Hongbiao , Zheng Xiaoting , Zhang Jiasong 
Published: November 2024

IntroductionThe use of plant essential oils as anesthetics for fish has gained increasing attention, but ethanol, often used as a co-solvent, presents certain limitations. Recently, Magnolia denudata essential oil (MDO) has emerged as a promising alternative for fish anesthesia and sedation.Methods and resultsTo further improve MDO anesthesia efficacy, this study developed nanoemulsion (NE) and self-microemulsifying drug delivery system (SMEDDS) formulations of MDO. Transmission electron microscopy and stability tests confirmed that both NE and SMEDDS possess smaller particle sizes and are stable under various temperature conditions. Anesthetic trials on fish demonstrated that these formulations reduced the time needed to induce anesthesia compared with the non-formulations. Additionally, physiological assessments of the fish gills showed that neither NE nor SMEDDS caused irreversible damage to respiratory function.DiscussionOverall, NE and SMEDDS present a safe and effective delivery system for MDO, enhancing its anesthetic properties while minimizing potential harm to aquatic organisms compared to traditional methods.
Effects of Pulsed Electric Fields on the Elimination of Fusarium oxysporum in Greenhouse Soil
Authors: Chen Jie , Sun Yingjian , Cui Qingliang , Hao Xiaojuan , Liu Zhenyu , Li Guang 
Published: November 2024

In greenhouses, high humidity, low light, and inadequate ventilation conditions, along with continuous and high-density planting, promote the proliferation of soilborne pathogens. Among these pathogens, Fusarium oxysporum Schltdl (F. oxysporum) is a notably challenging one, causing root rot of tomato plants in greenhouse cultivation. To address this issue, this study applied a pulsed electric field (PEF) to target the elimination of F. oxysporum in suspension and soil media. Initially, PEF parameters were systematically explored in suspensions to determine the effective ranges for the elimination of F. oxysporum. The results revealed that the effective ranges for achieving the desired microbial reduction were an electric field strength (EFS) between 5–15 kV·cm−1, a pulse number within the range of 100–500, and a pulse width of 10–20 µs. Subsequently, the impact of soil moisture content, soil bulk density, and soil type on soil dielectric breakdown field strength was analyzed within the range from previous results. Based on these findings, the soil experiments were conducted with parameters designed to prevent dielectric breakdown. Specifically, for sampling soil with a moisture content of 16.2% and a bulk density of 1.31 g·cm−3, the maximum effective application of electric field strength was 9.5 kV·cm−1, accompanied by 1000 pulses and a pulse width of 20 µs. Finally, building on these results, soil samples were sterilized within a parameter range that spanned an electric field strength of 5–9.5 kV·cm−1, a pulse number between 100–500, and a pulse width of 10–20 µs. Response surface methodology (RSM) analysis further identified the optimal parameter combination: an electric field strength of 8.2 kV·cm−1, 306 pulses, and a pulse width of 15 µs, resulting in an average lethal rate of 76.16% for F. oxysporum sterilization in soil. These findings suggest the potential use of PEF against F. oxysporum and other pathogens in greenhouse soils, and provide theoretical foundations for further experiments, thereby contributing to the sustainable advancement of greenhouse agriculture.
Mitochondrial Genome Assembly and Comparative Analysis of Chionanthus Retusus (Oleaceae)
Authors: Zhai Shasha , Lin Furong , Shu Xiuge , Niu Hongyun , Jing Qi , Gao Lei , Gao Xiangbin , Liu Dan 
Published: November 2024

Background/Objectives: Chionanthus retusus Lindl. & Paxton is an ornamental tree species native to North China. Research on the mitochondrial genome can elucidate the evolution and biological characteristics of C. retusus and better protect this important species. Methods and Results: This work aimed to clarify the evolutionary and phylogenetic links by sequencing, assembling, annotating, and analyzing the entire mitochondrial genome of C. retusus. The single-loop structure that made up the mitochondrial genome had a total length of 657,640 bp and a GC content of 44.52%. In total, 37 unique protein-coding genes, 20 tRNA genes, and 3 rRNA genes were identified. Numerous repeat sequences and migrating fragments of chloroplast sequences were found. Using the mitochondrial protein-coding genes to construct evolutionary trees, it was found that the closest relative of C. retusus is C. rupicola (Lingelsh.) Kiew. Conclusions: This research represents the first comprehensive set of data on the mitochondrial genome of an ancient (>500 yr) C. retusus specimen. In addition to elucidating the biological characteristics of C. retusus. The findings contribute to the Oleaceae mitochondrial genome database and offer valuable insights for future studies in molecular breeding, evolutionary biology, and genetic diversity conservation.
Exploring the Linkage Between Ruminal Microbial Communities on Postweaning and Finishing Diets and Their Relation to Residual Feed Intake in Beef Cattle
Authors: Peraza Pablo , Fernández-Calero Tamara , Naya Hugo , Sotelo-Silveira José , Navajas Elly A. 
Published: November 2024

Feed efficiency significantly impacts the economics of beef production and is influenced by biological and environmental factors. The rumen microbiota plays a crucial role in efficiency, with studies increasingly focused on its relationship with different rearing systems. This study analyzed 324 rumen samples from bulls and steers categorized as high and low efficiency based on residual feed intake. The animals were fed two diets (postweaning and finishing) and rumen samples were sequenced using a reduced representation sequencing (RRS) based approach. The results indicated that diet significantly affected microbial diversity and abundance. In postweaning diets, Actinomycetota, particularly Bifidobacterium, were prevalent, aiding carbohydrate fermentation. In contrast, Acetoanaerobium was identified in finishing diets, likely contributing to acetate production. Additionally, Bacteroides and Butyrivibrio were abundant during postweaning, known for fiber degradation and volatile fatty acid production. Notably, Prevotella and Fibrobacter succinogenes were associated with high feed intake and nutrient utilization, indicating their potential as microbial biomarkers. However, alpha diversity indices showed no significant relationship with feed efficiency, suggesting that diversity alone may not adequately reflect the complexity of feed efficiency phenotypes. These findings highlight the importance of diet and microbial interactions on feed efficiency and suggest further research to explore these microbial contributions to precision feeding strategies.
ДОМ И САД С.Н.ДУРЫЛИНА В БОЛШЕВО КАК ПРОСТРАНСТВО КУЛЬТУРЫ
Authors: Георгий Владимирович Нефедьев 
Published: November 2024

Дом С.Н. Дурылина в Болшево становится центром духовной культуры Подмосковья в1930-950-х годах XX в. На основании мемуарных свидетельств современников и гостей Дома, а также архивных материалов, хранящихся в Мемориальном Доме-музее С.Н. Дурылина, предлагается проект реконструкции аутентичного облика сада. Обосновывается необходимость реставрации дурылинского сада как важного компонента уникального центра культуры.
The article is devoted to a unique garden located around the S.N. Memorial House-Museum Durilina in Bolshevo. Built in 1936, the House becomes the center of the spiritual culture of the Moscow Region in the 1930s and 1950s of the 20th century. Based on memoirs of contemporaries and guests of the e-House, as well as archival materials stored in the Memorial House-Museum of S.N. Durilina, an attempt is being made to reconstruct the appearance of the garden as it was during the life of its owner. The article proposes to begin the restoration of the Durylinsky garden with the involvement of all the actual material available in the museum.
ГЕОКУЛЬТУРНАЯ МАТРИЦА КАК ЦИФРОВАЯ ПЛАТФОРМА ИЗУЧЕНИЯ ОБЪЕКТОВ КУЛЬТУРНОГО НАСЛЕДИЯ В РОССИЙСКОЙ ФЕДЕРАЦИИ
Authors: Юрий Степанович Путрик 
Published: November 2024

Процессы цифровизации затронули и сферу деятельности по учету, сохранению, изучению, популяризации и использованию объектов культурного наследия. Единый государственный реестр объектов культурного наследия народов Российской Федерации представляет собой внушительный цифровой массив сведений, который становится всё более значимой предпосылкой для проведения не только мониторинга, но и более глубоких исследований о состоянии и тенденциях в деле охраны и использования объектов культурного и природного наследия на территории России.
Digitalization processes have also affected the sphere of activity in recording, preserving, studying, popularizing and using objects of cultural heritage as a key component of Russian civilization. The Unified State Register of Cultural Heritage Objects of the Peoples of the Russian Federation is an impressive digital array of information, which is becoming an increasingly important prerequisite for not only monitoring, but also more in-depth research on the status and trends in the protection and use of cultural and natural heritage in Russia.
КУЛЬТУРНОЕ И КОНФЕССИОНАЛЬНОЕ ВЛИЯНИЕ РОМЕЙСКОЙ ИМПЕРИИ НА ОКРУЖАЮЩИЕ НАРОДЫ В IX-X ВЕКАХ
Authors: Дмитрий Михайлович Абрамов 
Published: November 2024

Культурное и конфессиональное влияние Ромейской империи с одной стороны обогатило традиции и жизнь многих окрестных народов. Огромную роль в этом деле сыграло подвижничество славянских просветителей святых Кирилла и Мефодия. С другой стороны, распространение ортодоксального христианского учения вызвало политическое и военное противостояние между западными и восточными иерархами Вселенской Церкви.
The cultural and confessional influence of the Roman Empire on the one hand enriched the traditions and life of many surrounding peoples. A huge role in this matter was played by the asceticism of the Slavic enlighteners Saints Cyril and Methodius. On the other hand, the spread of orthodox Christian teaching caused political and military confrontation between the western and eastern hierarchs of the Ecumenical Church.