bluuebunny/crossref_metadata_2025_split huggingface dataset:
КЛІНІКО-ЕКОНОМІЧНА ЕФЕКТИВНІСТЬ ЗАСТОСУВАННЯ КАМФОРНОЇ ОЛІЇ ПРИ ДЕРМАТИТІ, АСОЦІЙОВАНОМУ З НЕТРИМАННЯМ
Authors: Kohut I. Y. , Galnykina S. O. 
Published: May 2019

Мета роботи: дослідити клініко-економічну ефективність камфорної олії у лікуванні дерматиту, асоційованого з нетриманням.
Матеріали і методи. У перспективне спостережне дослідження увійшли 134 дорослі пацієнти з дерматитом, асоційованим з нетриманням. У досліджуваній групі (n = 104) для очищення і захисту шкіри використовувалась камфорна олія. У контрольній групі (n=30) застосовували вологі салфетки 3 в 1 або комбінацію піни для очищення шкіри та захисного крему. Середній вік пацієнтів становив 77 ± 11 (діапазон 36 – 92) років, з них 83 (61,9 %) жінок. У всіх пацієнтів було наявне нетримання сечі, яке поєднувалося з нетриманням калу у 48 (35,8 %) осіб. Зразки змивів шкіри висіювалися на середовище Сабуро для грибів і культивувалися 48 – 72 год при температурі 37°С до виділення Candida spp. Статистична обробка результатів виконувалась за допомогою програмного забезпечення Microsoft Excel® 2016 та MedCalc®. Зміна показників вважалася достовірною при рівні значимості не менше 0,05 (р<0,05). Порівняння між показниками груп проводилось за допомогою регресійного аналізу з визначенням відношення шансів при 95 % довірчому інтервалі.
Результати. Через 1 місяць використання досліджуваного препарату відбулося достовірне зменшення числа осіб з категорією GLOBIAD 2В з 30 (28,8 %)до 16 (15,4 %) пацієнтів (χ2 = 22,1; p < 0,001) та збільшення чисельності категорії 1А з 29 (27,9 %) до 52 (50,0 %) пацієнтів (χ2 = 12,07; p < 0,001). Грибковоподібний висип спостерігався на початковому візиті у 53 (51,0 %) досліджуваних хворих, який, після курсу лікування, достовірно зменшився і визначався у 33 (31,7 %) осіб (χ2 = 16,4; p < 0,001). Грибковоподібний висип був підтверджений мікологічно у 30 (28,8%) досліджуваних, а після курсу лікування лише у 8 (7,8%) хворих (χ2 = 20,05; p < 0,001). Економічний аналіз показав, що одна процедура догляду за шкірою за допомогою камфорної олії коштувала 0,65 грн, тоді як у групі контролю на рутинні засоби витрачалося 1,65 грн.
Висновки. Місцеве застосування камфорної олії призвело до достовірного покращення клінічного перебігу захворювання, зменшення кількості випадків грибковоподібного висипу, зниження частоти колонізації шкіри Candida spp., а також виявилось економічно вигідним у порівнянні з рутинними засобами догляду за шкірою в осіб з дерматитом, асоційованим з нетриманням.
ДИНАМІКА ТА ПЕРСПЕКТИВИ ТВОРЕННЯ ПОНЯТЬ В ОСВІТНЬОМУ ПРОЦЕСІ
Authors: Sokol M. O. , Szempruch Y. 
Published: May 2019

Мета роботи – висвітлення розвитку понятійно-категорійного апарату в освітній галузі.
Основна частина. У статті розглядаються теоретичні концепції динаміки та розвитку понять в освітньому процесі. В умовах інтеграційних устремлінь України важливим є осмислення перспектив розвитку вітчизняної науки, включно з освітою, понятійно-категорійного апарату педагогіки з метою гармонізації зі світовими та європейськими векторами. Доведено, що системний рівень наукових понять, що відображає ступінь розвитку його теорії і розкриває взаємозв’язок об’єктів і різноманіття пізнавальних ситуацій, що виникають під час навчання, виховання особистості, і дозволяє учаснику чітко окреслити предмет дослідження та побудувати його послідовну концепцію. Враховуючи технічні нововведення сучасної педагогічної науки, було припущено, що чітка система понять є невід’ємною складовою освітнього процесу. Актуальність дослідження авторами обумовлена суб’єктивною детермінацією понятійно-категорійного апарату, що проявляється у загальних тенденціях у різних наукових галузях.
На основі сутнісного аналізу понять “людина”, “індивід”, “особистість” та їх експлікації доведено різноплановість тракту­вання понятійно-категорійного апарату у вітчизняному та зарубіжному наукових просторах. Обґрунтовано необхідність вивчення основних тенденцій розвитку понятійно-категорійного апарату педагогічної науки. Було виокремлено тріаду педагогічних понять “людина”, “індивід”, “особистість”.
Висновки. Підсумуємо, що освітній понятійно-категоріальний апарат є однією з умов розвитку світової педагогічної культури як цілісної якості, що забезпечує розвиток індивідуальної педагогічної культури, оволодіння науковими теоріями, освітніми технологіями в єдиному, багатокультурному інформаційному та освітньому просторі. Оскільки педагогічна система понять стає інструментом пошуку нових орієнтирів, які розвивають освітню галузь та сприяють всебічному розвиткові особистості.
The Neotropical caddisfly genus Canoptila (Trichoptera: Glossosomatidae)
Authors: ROBERTSON DESIREE R. , HOLZENTHAL RALPH W. 
Published: May 2019

The caddisfly genus Canoptila Mosely (Glossosomatidae: Protoptilinae), endemic to southeastern Brazil, is diagnosed and discussed in the context of other protoptiline genera, and a brief summary of its taxonomic history is provided. A new species, Canoptila williami, is described and illustrated, including a female, the first known for the genus. Additionally, the type species, Canoptila bifida Mosely, is redescribed and illustrated. There are three possible synapomorphies supporting the monophyly of Canoptila: 1) the presence of long spine-like posterolateral processes on tergum X; 2) the highly membranous digitate parameres on the endotheca; and 3) the unique combination of both forewing and hind wing venational characters.
Predictive Capability of a High-Resolution Hydrometeorological Forecasting Framework Coupling WRF Cycling 3DVAR and Continuum
Authors: Lagasio Martina , Silvestro Francesco , Campo Lorenzo , Parodi Antonio 
Published: May 2019

Abstract
The typical complex orography of the Mediterranean coastal areas support the formation of the so-called back-building mesoscale convective systems (MCS) producing torrential rainfall often resulting in flash floods. As these events are usually very small-scaled and localized, they are hardly predictable from a hydrometeorological standpoint, frequently causing a significant amount of fatalities and socioeconomic damage. Liguria, a northwestern Italian region, is characterized by small catchments with very short hydrological response time and is thus extremely prone to the impacts of back-building MCSs. Indeed, Liguria has been hit by three intense back-building MCSs between 2011 and 2014, causing a total death toll of 20 people and several hundred millions of euros of damages. Consequently, it is necessary to use hydrometeorological forecasting frameworks coupling the finescale numerical weather prediction (NWP) outputs with rainfall–runoff models to provide timely and accurate streamflow forecasts. Concerning the aforementioned back-building MCS episodes that recently occurred in Liguria, this work assesses the predictive capability of a hydrometeorological forecasting framework composed by a kilometer-scale cloud-resolving NWP model (WRF), including a 6-h cycling 3DVAR assimilation of radar reflectivity and conventional weather stations data, a rainfall downscaling model [Rainfall Filtered Autoregressive Model (RainFARM)], and a fully distributed hydrological model (Continuum). A rich portfolio of WRF 3DVAR direct and indirect reflectivity operators has been explored to drive the meteorological component of the proposed forecasting framework. The results confirm the importance of rapidly refreshing and data intensive 3DVAR for improving the quantitative precipitation forecast, and, subsequently, the flash flood prediction in cases of back-building MCS events.
On the Legacy of Genetically Altered Mouse Models to Explore Vestibular Function: Distribution of Vestibular Hair Cell Phenotypes in the Otoferlin-Null Mouse
Authors: Prins Terry J. , Saldate Johnny J. , Berke Gerald S. , Hoffman Larry F. 
Published: May 2019

Objectives: Early in his career, David Lim recognized the scientific impact of genetically anomalous mice exhibiting otoconia agenesis as models of drastically compromised vestibular function. While these studies focused on the mutant pallid mouse, contemporary genetic tools have produced other models with engineered functional modifications. Lim and colleagues foresaw the need to analyze vestibular epithelia from pallid mice to verify the absence of downstream consequences that might be secondary to the altered load represented by otoconial agenesis. More generally, however, such comparisons also contribute to an understanding of the susceptibility of labyrinthine sensory epithelia to more widespread cellular changes associated with what may appear as isolated modifications. Methods: Our laboratory utilizes a model of vestibular hypofunction produced through genetic alteration, the otoferlin-null mouse, which has been shown to exhibit severely compromised stimulus-evoked neurotransmitter release in type I hair cells of the utricular striola. The present study, reminiscent of early investigations of Lim and colleagues that explored the utility of a genetically altered mouse to explore its utility as a model of vestibular hypofunction, endeavored to compare the expression of the hair cell marker oncomodulin in vestibular epithelia from wild-type and otoferlin-null mice. Results: We found that levels of oncomodulin expression were much greater in type I than type II hair cells, though were similar across the 3 genotypes examined (ie, including heterozygotes). Conclusion: These findings support the notion that modifications resulting in a specific component of vestibular hypofunction are not accompanied by widespread morphologic and cellular changes in the vestibular sensory epithelia.
External Auditory Canal Reconstruction and Mastoid Obliteration Using Modified Palva Flap in Canal Wall Down Mastoidectomy With Tympanoplasty
Authors: Kim Ji-Sun , Lim Il Gye , Oh Jeong-Hoon , Kim Byung Guk , Chang Ki-Hong 
Published: May 2019

Objective: To evaluate the effectiveness of a modified Palva flap used for external auditory canal reconstruction and mastoid obliteration in canal wall down mastoidectomy. Methods: We retrospectively analyzed patients who underwent canal wall down mastoidectomy with tympanoplasty using modified Palva flap. All patients underwent pure tone audiometry and temporal bone computed tomography (CT) before surgery, and the same tests were performed in the first year after surgery. The external auditory canal volumes were calculated by summing the areas of each section selected in temporal bone CT. For each patient, the ratio of external auditory canal volume was calculated from CT taken before and after surgery. Results: The mean of external auditory canal volume after canal wall down with a modified Palva flap was about 1.4 times larger than before surgery. The modified Palva flap is effective for the reconstruction of the external auditory canal. Both pure tone audiometry level and air-bone gap showed statistically significant improvement after surgery ( Ps = .001 and .002, respectively). Conclusions: The external auditory canal volume slightly increased, but the status of mastoid obliteration was well maintained 1 year after surgery. The modified Palva flap used in this study is an easy and effective method in external auditory canal reconstruction and mastoid obliteration.
Phantom Perception of Sound and the Abnormal Cortical Inhibition System: An Electroencephalography (EEG) Study
Authors: Kyong Jeong-Sug , Noh Tae-Soo , Park Moo Kyun , Oh Seung-Ha , Lee Jun Ho , Suh Myung-Whan 
Published: May 2019

Objectives: Despite no observable external sound present, a perceived feeling of a recurrent unpleasant sound is a main complaint in the patients with chronic tinnitus. This phantom perception of sound is considered as the auditory equivalent of phantom limb pain, and altered excitability may be involved in its underlying pathology. Tinnitus-related hyper-excitation is suppressed by inhibitory repetitive transcranial magnetic stimulation (rTMS). However, the neural mechanism underlying the treatment is not fully understood, and quantifying the suppression induced by rTMS has yet to be considered. Methods: We evaluated the effect of rTMS on the cortical inhibition status following single-site stimulation over the auditory temporal cortex (T group) or dual-site stimulation over the auditory temporal and the frontal regions (TF group). These effects were also compared with outcomes following sham stimulation (S group). Subjective response was recorded using tinnitus-related handicap index (THI), and changes in the cortical inhibition status were assessed using an auditory paired-pulse suppression index (PPSI). Results: TF group showed the greatest benefit from the treatment evidenced in the reduced PPSI and THI scores. T and S groups did not benefit much. TF group overlapped mostly with the responder group, indicating improvement in both subjective THI and objective PPSI measurements. Conclusion: Our results suggest that rTMS is a beneficial therapeutic treatment for chronic tinnitus patients and the dual-site treatment was the most effective in terms of both tinnitus complaint and quantitative indices. Thus, subjective reports and electrophysiological signatures may be complementary for the diagnosis/prognosis of tinnitus.
Low-dose Oral Methotrexate Management of Patients with Bilateral Ménière's Disease
Authors: Kilpatrick Jefferson K. , Sismanis Aristides , Spencer Robert F. , Wise Christopher M. 
Published: May 2019

In this retrospective clinical trial, we evaluated the effectiveness of low-dose oral methotrexate in the management of bilateral Ménière's disease of immune-mediated origin. At our tertiary-care referral center, we evaluated ten men and eight women who had longstanding bilateral Ménière's disease that had been unresponsive to traditional conservative medical management. Sixteen of these patients had steroid-responsive bilateral Ménière's disease. Two patients had contraindications to steroids, but their clinical and laboratory evaluations were consistent with an immune-mediated process. Patients were treated with 7.5 to 20 mg/week of oral methotrexate. The mean duration of treatment was 16.7 months (range: 8 to 35), with a mean followup of 2 years (range: 9 mo to 5 yr). Changes in clinical symptoms (vertigo, hearing loss, tinnitus, and aural fullness), audiometric changes, and side effects of therapy were evaluated. Vertigo resolved in 14 patients (78%), was substantially alleviated in three patients (17%), and remained unchanged in one patient (6%). Hearing improved in five patients (28%) and stabilized in seven patients (39%). Tinnitus and aural fullness resolved or was relieved in 11 of 17 (65%) and 13 of 14 (93%) patients, respectively. Side effects were minimal and reversible. We conclude that low-dose oral methotrexate is effective and safe for treating bilateral Ménierè's disease of immune-mediated origin. In this study, methotrexate alleviated vertiginous symptoms and improved or stabilized hearing in most patients. Low-dose methotrexate can be considered for patients with immune-mediated bilateral Meniérè's disease when long-term treatment is required or when a steroid or cyclophosphamide is contraindicated.
Uvulectomy in the Office Setting
Authors: Ariyasu Laurence , Young Gary , Spinelli Frank 
Published: May 2019

Snoring is a common problem which affects 50% of male and 30% of female patients.1 In a small number of patients, partial uvulopalatoplasty in the office setting has been found to ameliorate loud snoring.2 In our study, 28 patients had uvulectomy for snoring, 17 of whom responded to our survey. The procedure was somewhat beneficial (rated 3.2 on a scale of 10, with 10 representing no snoring) and had little impact on quality of life (rated 2.7 on a scale of 10, with 10 representing great improvement). After the procedure patients had considerable pain (rated 7.4 on a scale of 10, with 10 representing excruciating pain) which lasted >10 days in 35% and led to a mean of 2.9 missed work days. There were no complications. Fourteen of 17 patients wanted additional treatment to reduce snoring.
Branchial Cleft Cyst Posterior to the Carotid Vessels
Authors: Halvorson David J. , Porubsky Edward S. 
Published: May 2019

Branchial cleft anomalies may appear as a sinus fistula or cyst. An understanding of the developmental embryology and anatomy can predict branchial cleft anomalies by the relationship of the corresponding branchial arches that form at the time of development. The second branchial cleft anomalies are the most common and may be found along a tract from the anterior border of the sternocleidomastoid muscle anterior to the carotid vessels and IX and XII. A cyst may form anywhere along this tract but most commonly is just lateral to the internal jugular vein anterior to the carotid vessels. We describe a patient with a second branchial cleft cyst that was posterior to the carotid vessels documented by computed tomography. The cyst was found intraoperatively to be clearly posterior to the common carotid artery. This case demonstrates the need for an understanding of developmental embryology, anatomical landmarks and variations.
The 3849+10 kB C—>T Mutation in a 21-Year-Old Patient with Cystic Fibrosis
Authors: Kaplan D.M. , Niv A. , Aviram M. , Parvari R. , Leiberman A. , Fliss D.M. 
Published: May 2019

Cystic fibrosis (CF) is the most common lethal inherited disease in the white population. It is characterized by exocrine gland epithelia dysfunction, which leads to pulmonary and pancreatic insufficiency. Since the cloning of the CF gene in 1989 and the identification of the most common CF mutation (ΔF508), more than 400 different mutations have been described. These mutations appear to contribute to the heterogeneity of the CF phenotype and several reports have speculated on the relationship between the most common CF mutations and the patient's clinical status. We report the case of a 21-year-old woman with longstanding chronic pansinusitis, nasal polyposis, chronic cough and severe nasal crusting. During a period of five years she had been followed by her otolaryngologist and pediatric pulmonologist. Sweat tests performed at the age of 17 and 18 were within normal limits and she underwent repeated conventional sinonasal procedures, with no improvement in her clinical status. On her present admission, sweat tests showed a 70 meq/l chloride concentration. The diagnosis of CF was then confirmed by DNA analysis and the patient was found to carry the 3849+10 kB C—>T mutation. The early detection of this newly recognized form of CF in adults as well as in children presenting with sinonasal symptoms is critical for life expectancy and quality.
The Bone-Anchored Hearing Aid (BAHA) in Children with Auricular Malformations
Authors: Granström Gösta , Tjellström Anders 
Published: May 2019

A retrospective study was undertaken to evaluate the outcome of the use of the bone-anchored hearing aid (BAHA) in children. All patients included in the study had bilateral auricular malformations. Previous alternatives had been conventional hearing aids or surgical middle ear reconstruction. Thirty-seven patients under 16 years of age were studied. The most common syndrome in the group was Treacher Collins. Sixteen of the patients had earlier middle ear reconstruction, the results of which did not produce social hearing. Of 40 inserted fixtures to anchor the BAHA, three were lost during the follow-up period because of failed osseointegration. Skin reactions were graded according to a clinical scoring system and were determined to be comparable in number and severity to those of an adult population. All patients in the study considered the BAHA to be superior to earlier bone-conduction devices. It is concluded that the BAHA is an excellent alternative to bone-conduction devices in children with auricular malformations. Middle ear surgery can be postponed until adulthood or abandoned, especially in syndromic patients in whom it is known to be difficult and unpredictable.
Oat Cell Carcinoma of the Tongue from an Unknown Primary
Authors: Mitchell Ron B. , Stedeford Judith , Buchanan George 
Published: May 2019

Oat cell carcinoma is rarely diagnosed in the head and neck and can be primary or secondary. Primary tumors arise from amine precursor uptake and decarboxylation cells which are found throughout the head and neck. Secondary deposits metastasize most commonly from the lungs. We report a 64-year-old woman with a known pancreatic oat cell carcinoma who came to the ENT Department with dysphagia. On examination, a lesion was seen at the base of the tongue and was histologically an oat cell carcinoma. No treatment was administered and the patient died one month after discharge. This report highlights the difficulty in determining the primary site when a rare tumor metastasizes to the head and neck and no autopsy findings are obtained. To our knowledge, oat cell carcinoma of the tongue has not been previously reported.
Neurofibromatosis Type 2: Genetic and Clinical Features
Authors: Evans D. Gareth 
Published: May 2019

For decades, neurofibromatosis type 2 (NF2) was misclassified with the more common neurofibromatosis type 1 (NF1), until 1987 when it was found via genetic linkage analysis that the gene for NF1 was localized to chromosome 17 and the gene for NF2 was localized to chromosome 22. Large, population-based studies have shown that vestibular schwannomas (VS), the hallmark of NF2, do not occur at increased frequency inpatients with NF1. Typical clinical features of NF2 are bilateral VS or a family history of NF2, plus either unilateral VS or any two of the following: meningioma, glioma, neurofibroma, schwannoma or posterior subcapsular lenticular opacities. Presymptomatic genetic tests are now possible in the majority of families, and it is hoped that somatic gene therapy will be developed for the treatment of this disease.
Teflon-Wire Piston or Stainless-Steel Bucket Stapes Prosthesis: Does it Make a Difference?
Authors: Farrior Jay B. , Temple Anne E. 
Published: May 2019

The goal of this study was to determine whether postoperative (implantation of a stapes prosthesis) hearing gain and the amount of air-bone gap overclosure are more improved with the Teflon-wire piston or with the stainless-steel bucket prosthesis. We retrospectively reviewed the outcomes of 82 surgeries that had been performed by the primary author; 41 of these patients had received a Fisch Teflon-wire piston, and 41 had received a Bailey-modified Robinson stainless-steel bucket prosthesis. The mean hearing gain for the patients who received the Teflon-wire piston was 23.3 dB after primary stapes surgery and 20.5 dB after revision surgery. Patients who received the stainless-steel bucket prosthesis experienced a mean hearing gain of 20.7 and 20.3 dB, respectively. Following primary stapes surgery, the air-bone gap overclosure was 4.4 dB with the Teflon-wire piston and 5.2 dB with the stainless-steel bucket prosthesis. There was no statistically significant difference in either hearing gain or air-bone gap overclosure between the two prostheses.