bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global GRACE Data Assimilation for Groundwater and Drought Monitoring: Advances and Challenges
Authors: Li Bailing , Rodell Matthew , Kumar Sujay , Beaudoing Hiroko Kato , Getirana Augusto , Zaitchik Benjamin F. , de Goncalves Luis Gustavo , Cossetin Camila , Bhanja Soumendra , Mukherjee Abhijit , Tian Siyuan , Tangdamrongsub Natthachet , Long Di , Nanteza Jamiat , Lee Jejung , Policelli Frederick , Goni Ibrahim B. , Daira Djoret , Bila Mohammed , de Lannoy Gabriëlle , Mocko David , Steele‐Dunne Susan C. , Save Himanshu , Bettadpur Srinivas 
Published: August 2019

AbstractThe scarcity of groundwater storage change data at the global scale hinders our ability to monitor groundwater resources effectively. In this study, we assimilate a state‐of‐the‐art terrestrial water storage product derived from Gravity Recovery and Climate Experiment (GRACE) satellite observations into NASA's Catchment land surface model (CLSM) at the global scale, with the goal of generating groundwater storage time series that are useful for drought monitoring and other applications. Evaluation using in situ data from nearly 4,000 wells shows that GRACE data assimilation improves the simulation of groundwater, with estimation errors reduced by 36% and 10% and correlation improved by 16% and 22% at the regional and point scales, respectively. The biggest improvements are observed in regions with large interannual variability in precipitation, where simulated groundwater responds too strongly to changes in atmospheric forcing. The positive impacts of GRACE data assimilation are further demonstrated using observed low‐flow data. CLSM and GRACE data assimilation performance is also examined across different permeability categories. The evaluation reveals that GRACE data assimilation fails to compensate for the lack of a groundwater withdrawal scheme in CLSM when it comes to simulating realistic groundwater variations in regions with intensive groundwater abstraction. CLSM‐simulated groundwater correlates strongly with 12‐month precipitation anomalies in low‐latitude and midlatitude areas. A groundwater drought indicator based on GRACE data assimilation generally agrees with other regional‐scale drought indicators, with discrepancies mainly in their estimated drought severity.
On the Use of Adaptive Ensemble Kalman Filtering to Mitigate Error Misspecifications in GRACE Data Assimilation
Authors: Shokri Ashkan , Walker Jeffrey P. , van Dijk Albert I. J. M. , Pauwels Valentijn R. N. 
Published: August 2019

AbstractThe ensemble Kalman filter (EnKF) has been proved as a useful algorithm to merge coarse‐resolution Gravity Recovery and Climate Experiment (GRACE) data with hydrologic model results. However, in order for the EnKF to perform optimally, a correct forecast error covariance is needed. The EnKF estimates this error covariance through an ensemble of model simulations with perturbed forcing data. Consequently, a correct specification of perturbation magnitude is essential for the EnKF to work optimally. To this end, an adaptive EnKF (AEnKF), a variant of the EnKF with an additional component that dynamically detects and corrects error misspecifications during the filtering process, has been applied. Due to the low spatial and temporal resolutions of GRACE data, the efficiency of this method could be different than for other hydrologic applications. Therefore, instead of spatially or temporally averaging the internal diagnostic (normalized innovations) to detect the misspecifications, spatiotemporal averaging was used. First, sensitivity of the estimation accuracy to the degree of error in forcing perturbations was investigated. Second, efficiency of the AEnKF for GRACE assimilation was explored using two synthetic and one real data experiment. Results show that there is considerable benefit in using this method to estimate the forcing error magnitude and that the AEnKF can efficiently estimate this magnitude.
Global Structure of Thermal Tides in the Upper Cloud Layer of Venus Revealed by LIR on Board Akatsuki
Authors: Kouyama T. , Taguchi M. , Fukuhara T. , Imamura T. , Horinouchi T. , Sato T. M. , Murakami S. , Hashimoto G. L. , Lee Y. J. , Futaguchi M. , Yamada T. , Akiba M. , Satoh T. , Nakamura M. 
Published: August 2019

AbstractLongwave Infrared Camera (LIR) on board Akatsuki first revealed the global structure of the thermal tides in the upper cloud layer of Venus. The data were acquired over three Venusian years, and the analysis was done over the areas from the equator to the midlatitudes in both hemispheres and over the whole local time. Thermal tides at two vertical levels were analyzed by comparing data at two different emission angles. Dynamical wave modes consisting of tides were identified; the diurnal tide consisted mainly of Rossby‐wave and gravity‐wave modes, while the semidiurnal tide predominantly consisted of a gravity‐wave mode. The revealed vertical structures were roughly consistent with the above wave modes, but some discrepancy remained if the waves were supposed to be monochromatic. In turn, the heating profile that excites the tidal waves can be constrained to match this discrepancy, which would greatly advance the understanding of the Venusian atmosphere.
Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis
Authors: Wilson Robin , Bossong Matthijs G. , Appiah-Kusi Elizabeth , Petros Natalia , Brammer Michael , Perez Jesus , Allen Paul , McGuire Philip , Bhattacharyya Sagnik 
Published: August 2019

AbstractAccumulating evidence points towards the antipsychotic potential of cannabidiol. However, the neurocognitive mechanisms underlying the antipsychotic effect of cannabidiol remain unclear. We investigated this in a double-blind, placebo-controlled, parallel-arm study. We investigated 33 antipsychotic-naïve subjects at clinical high risk for psychosis (CHR) randomised to 600 mg oral cannabidiol or placebo and compared them with 19 healthy controls. We used the monetary incentive delay task while participants underwent fMRI to study reward processing, known to be abnormal in psychosis. Reward and loss anticipation phases were combined to examine a motivational salience condition and compared with neutral condition. We observed abnormal activation in the left insula/parietal operculum in CHR participants given placebo compared to healthy controls associated with premature action initiation. Insular activation correlated with both positive psychotic symptoms and salience perception, as indexed by difference in reaction time between salient and neutral stimuli conditions. CBD attenuated the increased activation in the left insula/parietal operculum and was associated with overall slowing of reaction time, suggesting a possible mechanism for its putative antipsychotic effect by normalising motivational salience and moderating motor response.
Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo
Authors: Shin Hyogeun , Son Yoojin , Chae Uikyu , Kim Jeongyeon , Choi Nakwon , Lee Hyunjoo J. , Woo Jiwan , Cho Yakdol , Yang Soo Hyun , Lee C. Justin , Cho Il-Joo 
Published: August 2019

AbstractInvestigation and modulation of neural circuits in vivo at the cellular level are very important for studying functional connectivity in a brain. Recently, neural probes with stimulation capabilities have been introduced, and they provided an opportunity for studying neural activities at a specific region in the brain using various stimuli. However, previous methods have a limitation in dissecting long-range neural circuits due to inherent limitations on their designs. Moreover, the large size of the previously reported probes induces more significant tissue damage. Herein, we present a multifunctional multi-shank MEMS neural probe that is monolithically integrated with an optical waveguide for optical stimulation, microfluidic channels for drug delivery, and microelectrode arrays for recording neural signals from different regions at the cellular level. In this work, we successfully demonstrated the functionality of our probe by confirming and modulating the functional connectivity between the hippocampal CA3 and CA1 regions in vivo.
Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy
Authors: Javed Ibrahim , Peng Guotao , Xing Yanting , Yu Tianyu , Zhao Mei , Kakinen Aleksandr , Faridi Ava , Parish Clare L. , Ding Feng , Davis Thomas P. , Ke Pu Chun , Lin Sijie 
Published: August 2019

AbstractAlzheimer’s disease (AD) is the most prevalent form of neurodegenerative disorders, yet no major breakthroughs have been made in AD human trials and the disease remains a paramount challenge and a stigma in medicine. Here we eliminate the toxicity of amyloid beta (Aβ) in a facile, high-throughput zebrafish (Danio rerio) model using casein coated-gold nanoparticles (βCas AuNPs). βCas AuNPs in systemic circulation translocate across the blood brain barrier of zebrafish larvae and sequester intracerebral Aβ42 and its elicited toxicity in a nonspecific, chaperone-like manner. This is evidenced by behavioral pathology, reactive oxygen species and neuronal dysfunction biomarkers assays, complemented by brain histology and inductively coupled plasma-mass spectroscopy. We further demonstrate the capacity of βCas AuNPs in recovering the mobility and cognitive function of adult zebrafish exposed to Aβ. This potent, safe-to-use, and easy-to-apply nanomedicine may find broad use for eradicating toxic amyloid proteins implicated in a range of human diseases.
Switchable magnetic bulk photovoltaic effect in the two-dimensional magnet CrI3
Authors: Zhang Yang , Holder Tobias , Ishizuka Hiroaki , de Juan Fernando , Nagaosa Naoto , Felser Claudia , Yan Binghai 
Published: August 2019

AbstractThe bulk photovoltaic effect (BPVE) rectifies light into the dc current in a single-phase material and attracts the interest to design high-efficiency solar cells beyond the pn junction paradigm. Because it is a hot electron effect, the BPVE surpasses the thermodynamic Shockley–Queisser limit to generate above-band-gap photovoltage. While the guiding principle for BPVE materials is to break the crystal centrosymmetry, here we propose a magnetic photogalvanic effect (MPGE) that introduces the magnetism as a key ingredient and induces a giant BPVE. The MPGE emerges from the magnetism-induced asymmetry of the carrier velocity in the band structure. We demonstrate the MPGE in a layered magnetic insulator CrI3, with much larger photoconductivity than any previously reported results. The photocurrent can be reversed and switched by controllable magnetic transitions. Our work paves a pathway to search for magnetic photovoltaic materials and to design switchable devices combining magnetic, electronic, and optical functionalities.
Longitudinal time course of muscle impairments during partial weight-bearing in rats
Authors: Mortreux Marie , Ko Frank C. , Riveros Daniela , Bouxsein Mary L. , Rutkove Seward B. 
Published: August 2019

AbstractIn the near future, space agencies plan to send the first crews for extended stays on the Moon and Mars, where gravity is significantly reduced compared to Earth (0.16×g and 0.38×g, respectively). However, the long-term effects of partial gravity have not yet been elucidated, and ensuring astronauts’ health and performance is crucial to the success of these missions. Using a quadrupedal partial weight-bearing (PWB) model in rats that we designed, we investigated the longitudinal time course of muscle function at three different PWB levels. We demonstrated that both muscle mass and muscle function are significantly impaired in reduced weight-bearing environments as early as after 7 days of suspension. Moreover, we showed that muscular alterations are correlated to the PWB level and do not reach a plateau during a 1-month exposure to reduced weight-bearing, emphasizing the need for mitigating countermeasures for safe and successful extraterrestrial exploration.
Epitope Mapping by NMR of a Novel Anti-Aβ Antibody (STAB-MAb)
Authors: Posado-Fernández Adrián , Afonso Cláudia F. , Dória Gonçalo , Flores Orfeu , Cabrita Eurico J. 
Published: August 2019

AbstractAlzheimer´s Disease (AD) is one of the most common neurodegenerative disorders worldwide. Excess of β-amyloid (Aβ), a peptide with a high propensity to misfold and self-aggregate, is believed to be the major contributor to the observed neuronal degeneration and cognitive decline in AD. Here, we characterize the epitope of a novel anti-Aβ monoclonal antibody, the STAB-MAb, which has previously demonstrated picomolar affinities for both monomers (KD = 80 pM) and fibrils (KD = 130 pM) of Aβ(1–42) and has shown therapeutic efficacy in preclinical mouse models of AD. Our findings reveal a widespread epitope that embraces several key Aβ residues that have been previously described as important in the Aβ fibrillation process. Of note, STAB-MAb exhibits a stronger affinity for the N-terminus of Aβ and stabilizes an α-helix conformation in the central to N-terminal region of the peptide, in addition to disrupting a characteristic salt-bridge of a hairpin structure present in fibrils. The NMR derived epitope supports the observed results from ThT-monitored fluorescence and electron microscopy experiments, in which STAB-MAb was shown to inhibit the formation of aggregates and promote disruption of pre-formed fibrils. In combination with the published in vitro and in vivo assays, our study highlights STAB-MAb as a rare and versatile antibody with analytical, diagnostic and therapeutic efficacy.
Dynamics of Forest Fragmentation and Connectivity Using Particle and Fractal Analysis
Authors: Andronache Ion , Marin Marian , Fischer Rico , Ahammer Helmut , Radulovic Marko , Ciobotaru Ana-Maria , Jelinek Herbert F. , Di Ieva Antonio , Pintilii Radu-Daniel , Drăghici Cristian-Constantin , Herman Grigore Vasile , Nicula Alexandru-Sabin , Simion Adrian-Gabriel , Loghin Ioan-Vlad , Diaconu Daniel-Constantin , Peptenatu Daniel 
Published: August 2019

AbstractThe ever decreasing area of forests has lead to environmental and economical challenges and has brought with it a renewed interest in developing methodologies that quantify the extent of deforestation and reforestation. In this study we analyzed the deforested areas of the Apuseni Mountains, which has been under economic pressure in recent years and resulted in widespread deforestation as a means of income. Deforested surface dynamics modeling was based on images contained in the Global Forest Database, provided by the Department of Geographical Sciences at Maryland University between 2000 and 2014. The results of the image particle analysis and modelling were based on Total Area (ha), Count of patches and Average Size whereas deforested area distribution was based on the Local Connected Fractal Dimension, Fractal Fragmentation Index and Tug-of-War Lacunarity as indicators of forest fragmentation or heterogeneity. The major findings of the study indicated a reduction of the tree cover area by 3.8%, an increase in fragmentation of 17.7% and an increase in heterogeneity by 29%, while fractal connectivity decreased only by 0.1%. The fractal and particle analysis showed a clustering of forest loss areas with an average increase from 1.1 to 3.0 ha per loss site per year. In conclusion, the fractal and particle analysis provide a relevant methodological framework to further our understanding of the spatial effects of economic pressure on forestry.
Mean diffusivity related to rule-breaking guilt: the Macbeth effect in the sensorimotor regions
Authors: Nakagawa Seishu , Takeuchi Hikaru , Taki Yasuyuki , Nouchi Rui , Kotozaki Yuka , Shinada Takamitsu , Maruyama Tsukasa , Sekiguchi Atsushi , Iizuka Kunio , Yokoyama Ryoichi , Yamamoto Yuki , Hanawa Sugiko , Araki Tsuyoshi , Makoto Miyauchi Carlos , Magistro Daniele , Sakaki Kohei , Jeong Hyeonjeong , Sasaki Yukako , Kawashima Ryuta 
Published: August 2019

AbstractGuilt, a self-conscious emotion, includes self-focused role taking and also correlates with other-oriented role-taking. Excess guilt proneness might be relevant to obsessive compulsive disorders. The white matter (WM) neural correlates of the degree of guilt have not yet been determined. We hypothesized that the WM structures involved in feelings of guilt are associated with social and moral cognition (inferior parietal lobule [IPL], prefrontal cortex [PFC], and cingulate), and aimed to visualize this using diffusion MRI. We investigated the association between regional WM structures (WM volume, and fractional anisotropy, and mean diffusivity [MD]), and feelings of guilt in 1196 healthy, young students using MRI and the Guilty Feeling Scale, which comprises interpersonal situation (IPS; guilt from hurting friends) and rule-breaking situation (RBS; deontological guilt) scores. The primary novel finding presented here is that MD in the right somatosensory and motor cortices from arm to hand were positively correlated with RBS scores. Further, consistent with our hypothesis, RBS scores were positively correlated with MD in the same regions. These results would be predicted by the Macbeth effect, an obsession with dirt leading to hand-washing rituals resulting from guilt, made famous by the Shakespearian character Lady Macbeth. “What, will these hands ne’er be clean?” William Shakespeare (Shakespeare, 1606) Macbeth.
Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter
Authors: Fukutomi Hikaru , Glasser Matthew F. , Murata Katsutoshi , Akasaka Thai , Fujimoto Koji , Yamamoto Takayuki , Autio Joonas A. , Okada Tomohisa , Togashi Kaori , Zhang Hui , Van Essen David C. , Hayashi Takuya 
Published: August 2019

AbstractDiffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) are widely used models to infer microstructural features in the brain from diffusion-weighted MRI. Several studies have recently applied both models to increase sensitivity to biological changes, however, it remains uncertain how these measures are associated. Here we show that cortical distributions of DTI and NODDI are associated depending on the choice of b-value, a factor reflecting strength of diffusion weighting gradient. We analyzed a combination of high, intermediate and low b-value data of multi-shell diffusion-weighted MRI (dMRI) in healthy 456 subjects of the Human Connectome Project using NODDI, DTI and a mathematical conversion from DTI to NODDI. Cortical distributions of DTI and DTI-derived NODDI metrics were remarkably associated with those in NODDI, particularly when applied highly diffusion-weighted data (b-value = 3000 sec/mm2). This was supported by simulation analysis, which revealed that DTI-derived parameters with lower b-value datasets suffered from errors due to heterogeneity of cerebrospinal fluid fraction and partial volume. These findings suggest that high b-value DTI redundantly parallels with NODDI-based cortical neurite measures, but the conventional low b-value DTI is hard to reasonably characterize cortical microarchitecture.
Polyubiquitination of p62/SQSTM1 is a prerequisite for Fas/CD95 aggregation to promote caspase-dependent apoptosis in cadmium-exposed mouse monocyte RAW264.7 cells
Authors: Jung Ki-Tae , Oh Seon-Hee 
Published: August 2019

AbstractCadmium(Cd) induces cytotoxicity via autophagy-induced apoptosis in non-activated mouse monocytes; however, the molecular mechanism remains unclear. Here, we show that autophagy induces Fas (CD95/APO-1)-mediated apoptosis by promoting accumulation of p62/SQSTM1 in response to Cd. Cd produced tumor necrosis factor (TNF)-α, peaking at 6 h, and exhibiting a concentration-dependent increase. Immunoblot analysis revealed polyubiquitinated (polyUb) full-length Fas (antibody clone G-9) and reduced cytosolic Fas (antibody clone M-20) in Cd-exposed RAW264.7 cells. The accumulation of polyUb-Fas was transient and positively correlated with polyUb-p62 and polyUb-proteins. Autophagy inhibition via chemical and genetic modulation suppressed Cd-induced polyUb-p62, polyUb-Fas, and polyUb-protein levels, whereas the level of cytosolic Fas recovered to that of the control. Immunofluorescence (IF) staining for full-length Fas, p62, and ubiquitin revealed an aggregated pattern in Cd-induced apoptotic cells, which was inhibited by blocking autophagy. Fas colocalized with microtubule-associated protein 1 light chain (LC)-3B. IF staining and immunoprecipitation assays revealed colocalization and interaction among p62, Ub, and Fas. Knockdown of p62 reduced the binding of Ub and Fas. Together, these data suggest that polyUb-p62 targets Fas and recruits it to autophagosomes, where Fas transiently aggregates to promote apoptosis and is degraded with polyUb-p62. In conclusion, autophagy regulates C-terminal cytosolic Fas aggregation via p62 polyubiquitination, which is required for apoptosis and may play a critical role in the production of select cytokines.
Formation of the Francisella tularensis Biofilm is Affected by Cell Surface Glycosylation, Growth Medium, and a Glucan Exopolysaccharide
Authors: Champion Anna E. , Catanzaro Kelly C. Freudenberger , Bandara Aloka B. , Inzana Thomas J. 
Published: August 2019

AbstractBiofilms are matrix-associated communities that enable bacteria to colonise environments unsuitable for free-living bacteria. The facultative intracellular pathogen Francisella tularensis can persist in water, amoebae, and arthropods, as well as within mammalian macrophages. F. tularensis Types A and B form poor biofilms, but F. tularensis mutants lacking lipopolysaccharide O-antigen, O-antigen capsule, and capsule-like complex formed up to 15-fold more biofilm than fully glycosylated cells. The Type B live vaccine strain was also 50% less capable of initiating surface attachment than mutants deficient in O-antigen and capsule-like complex. However, the growth medium of all strains tested also influenced the formation of biofilm, which contained a novel exopolysaccharide consisting of an amylose-like glucan. In addition, the surface polysaccharide composition of the bacterium affected the protein:DNA:polysaccharide composition of the biofilm matrix. In contrast, F. novicida attached to surfaces more efficiently and made a more robust biofilm than Type A or B strains, but loss of O-antigen or capsule-like complex did not significantly affect F. novicida biofilm formation. These results indicated that suppression of surface polysaccharides may promote biofilm formation by F. tularensis Types A and B. Whether biofilm formation enhances survival of F. tularensis in aquatic or other environmental niches has yet to be determined.