bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transport Properties of Se/As2Se3 Nanolayer Superlattice Fabricated Using Rotational Evaporation
Authors: John Joshua D. , Okano Shun , Sharma Apoorva , Selyshchev Oleksandr , Rahaman Mahfujur , Miyachi Noritoshi , Enomoto Kunitaka , Ochiai Jun , Saito Ichitaro , Masuzawa Tomoaki , Yamada Takatoshi , Chua Daniel H. C. , Zahn Dietrich R. T. , Okano Ken 
Published: August 2019

AbstractSince their proposal by Esaki, superlattices have been observed to have fascinating features such as quantum size effects, negative differential resistance, and sequential resonant tunneling. However, the technology threshold for fabricating superlattices is high, requiring methods like molecular beam epitaxy (MBE) and atomic layer deposition (ALD), among others, even for amorphous materials. Thus, the desirable features from superlattices have not been extensively utilized. It is shown that superlattices of Se and As2Se3 (superlattice‐Se), fabricated using rotational evaporation, exhibit sequential tunneling, a typical superlattice feature. From current–voltage measurements of the superlattice deposited on n‐type Si, oscillations in the characteristics are observed. Using models of reverse‐biased Schottky barriers, the observations are explained as tunneling in sequence from superlattice minibands. The superlattice‐Se also shows carrier blocking, with a resistivity of the order of 1012 Ω cm in dark conditions at room temperature, despite the low resistivity (≈10 Ω cm) of the n‐type Si substrate. When the Si is illuminated, the device shows higher detectivity for weaker signals compared to higher illumination. The ease of fabrication, and the blocking and amplifying capabilities make superlattice‐Se an interesting “add‐on” structure to improve conventional photodetector materials such as Si or Ge, which have issues with dark currents at room temperature.
Phthalocyanine–Virus Nanofibers as Heterogeneous Catalysts for Continuous‐Flow Photo‐Oxidation Processes
Authors: Anaya‐Plaza Eduardo , Aljarilla Ana , Beaune Grégory , Nonappa  , Timonen Jaakko V. I. , de la Escosura Andrés , Torres Tomás , Kostiainen Mauri A. 
Published: August 2019

AbstractThe generation of highly reactive oxygen species (ROS) at room temperature for application in organic synthesis and wastewater treatment represents a great challenge of the current chemical industry. In fact, the development of biodegradable scaffolds to support ROS‐generating active sites is an important prerequisite for the production of environmentally benign catalysts. Herein, the electrostatic cocrystallization of a cationic phthalocyanine (Pc) and negatively charged tobacco mosaic virus (TMV) is described, together with the capacity of the resulting crystals to photogenerate ROS. To this end, a novel peripherally crowded zinc Pc (1) is synthesized. With 16 positive charges, this photosensitizer shows no aqueous aggregation, and is able to act as a molecular glue in the unidimensional assembly of TMV. A step‐wise decrease of ionic strength in mixtures of both components results in exceptionally long fibers, constituted by hexagonally bundled viruses thoroughly characterized by electron and confocal microscopy. The fibers are able to produce ROS in a proof‐of‐concept microfluidic device, where they are immobilized and irradiated in several cycles, showing a resilient performance. The bottom‐up approach also enables the light‐triggered disassembly of fibers after use. This work represents an important example of a biohybrid material with projected application in light‐mediated heterogeneous catalysis.
Multilayered PdSe2/Perovskite Schottky Junction for Fast, Self‐Powered, Polarization‐Sensitive, Broadband Photodetectors, and Image Sensor Application
Authors: Zeng Long‐Hui , Chen Qing‐Ming , Zhang Zhi‐Xiang , Wu Di , Yuan Huiyu , Li Yan‐Yong , Qarony Wayesh , Lau Shu Ping , Luo Lin‐Bao , Tsang Yuen Hong 
Published: August 2019

AbstractGroup‐10 transition metal dichalcogenides (TMDs) with distinct optical and tunable electrical properties have exhibited great potential for various optoelectronic applications. Herein, a self‐powered photodetector is developed with broadband response ranging from deep ultraviolet to near‐infrared by combining FA1−xCsxPbI3 perovskite with PdSe2 layer, a newly discovered TMDs material. Optoelectronic characterization reveals that the as‐assembled PdSe2/perovskite Schottky junction is sensitive to light illumination ranging from 200 to 1550 nm, with the highest sensitivity centered at ≈800 nm. The device also shows a large on/off ratio of ≈104, a high responsivity (R) of 313 mA W−1, a decent specific detectivity (D*) of ≈1013 Jones, and a rapid response speed of 3.5/4 µs. These figures of merit are comparable with or much better than most of the previously reported perovskite detectors. In addition, the PdSe2/perovskite device exhibits obvious sensitivity to polarized light, with a polarization sensitivity of 6.04. Finally, the PdSe2/perovskite detector can readily record five “P,” “O,” “L,” “Y,” and “U” images sequentially produced by 808 nm. These results suggest that the present PdSe2/perovskite Schottky junction photodetectors may be useful for assembly of optoelectronic system applications in near future.
3D Printing of Hot Dog‐Like Biomaterials with Hierarchical Architecture and Distinct Bioactivity
Authors: Li Tian , Zhai Dong , Ma Bing , Xue Jianmin , Zhao Pengyu , Chang Jiang , Gelinsky Michael , Wu Chengtie 
Published: August 2019

AbstractHierarchical structure has exhibited an important influence in the fields of supercapacitors, catalytic applications, and tissue engineering. The hot dog, a popular food, is composed of bread and sausage with special structures. In this study, inspired by the structure of a hot dog, the strategy of combining direct ink writing 3D printing with bidirectional freezing is devised to prepare hot dog‐like scaffolds with hierarchical structure. The scaffolds are composed of hollow bioceramic tubes (mimicking the “bread” in hot dogs, pore size: ≈1 mm) embedded by bioceramic rods (mimicking the “sausage” in hot dogs, diameter: ≈500 µm) and the sausage‐like bioceramic rods possess uniformly aligned lamellar micropores (lamellar pore size: ≈30 µm). By mimicking the functions of hierarchical structure of bone tissues for transporting and storing nutrients, the prepared hot dog‐like scaffolds show excellent properties for loading and releasing drugs and proteins as well as for improving the delivery and differentiation of tissue cells. The in vivo study further demonstrates that both the hierarchical structure itself and the controlled drug delivery in hot dog‐like scaffolds significantly contribute to the improved bone‐forming bioactivity. This study suggests that the prepared hot dog‐like scaffolds are a promising biomaterial for drug delivery, tissue engineering, and regenerative medicine.
Paradoxical effects of optogenetic stimulation in mesial temporal lobe epilepsy
Authors: Lévesque Maxime , Chen Li‐Yuan , Etter Guillaume , Shiri Zahra , Wang Siyan , Williams Sylvain , Avoli Massimo 
Published: August 2019

ObjectiveTo establish the effects induced by long‐term, unilateral stimulation of parvalbumin (PV)‐positive interneurons on seizures, interictal spikes, and high‐frequency oscillations (80–500Hz) occurring after pilocarpine‐induced status epilepticus (SE)—a proven model of mesial temporal lobe epilepsy (MTLE)—in transgenic mice expressing or not expressing ChR2.MethodsPV‐ChR2 (n = 6) and PV‐Cre (n = 6) mice were treated with pilocarpine to induce SE. Three hours after SE onset, unilateral optogenetic stimulation (450nm, 25mW, 20‐millisecond pulses delivered at 8Hz for 30 seconds every 2 minutes) of CA3 PV‐positive interneurons was implemented for 14 continuous days in both groups.ResultsRates of seizures (p < 0.01), interictal spikes (p < 0.001), and interictal spikes with fast ripples (250–500Hz) (p < 0.001) were lower in PV‐ChR2 than in PV‐Cre mice. Ripples (80–200Hz) occurring outside of interictal spikes had higher rates in the PV‐ChR2 group (p < 0.01), whereas isolated fast ripples had lower rates (p < 0.01). However, seizure probability was higher during optogenetic stimulation in PV‐ChR2 compared to PV‐Cre animals (p < 0.05).InterpretationOur findings show that the unilateral activation of CA3 PV‐positive interneurons exerts anti‐ictogenic effects associated with decreased rates of interictal spikes and fast ripples in this MTLE model. However, PV‐positive interneuron stimulation can paradoxically trigger seizures in epileptic animals, supporting the notion that γ‐aminobutyric acid type A signaling can also initiate ictogenesis. ANN NEUROL 2019;86:714–728
Connectomic Profiling Identifies Responders to Vagus Nerve Stimulation
Authors: Mithani Karim , Mikhail Mirriam , Morgan Benjamin R. , Wong Simeon , Weil Alexander G. , Deschenes Sylvain , Wang Shelly , Bernal Byron , Guillen Magno R. , Ochi Ayako , Otsubo Hiroshi , Yau Ivanna , Lo William , Pang Elizabeth , Holowka Stephanie , Snead O. Carter , Donner Elizabeth , Rutka James T. , Go Cristina , Widjaja Elysa , Ibrahim George M. 
Published: August 2019

ObjectiveVagus nerve stimulation (VNS) is a common treatment for medically intractable epilepsy, but response rates are highly variable, with no preoperative means of identifying good candidates. This study aimed to predict VNS response using structural and functional connectomic profiling.MethodsFifty‐six children, comprising discovery (n = 38) and validation (n = 18) cohorts, were recruited from 3 separate institutions. Diffusion tensor imaging was used to identify group differences in white matter microstructure, which in turn informed beamforming of resting‐state magnetoencephalography recordings. The results were used to generate a support vector machine learning classifier, which was independently validated. This algorithm was compared to a second classifier generated using 31 clinical covariates.ResultsTreatment responders demonstrated greater fractional anisotropy in left thalamocortical, limbic, and association fibers, as well as greater connectivity in a functional network encompassing left thalamic, insular, and temporal nodes (p < 0.05). The resulting classifier demonstrated 89.5% accuracy and area under the receiver operating characteristic (ROC) curve of 0.93 on 10‐fold cross‐validation. In the external validation cohort, this model demonstrated an accuracy of 83.3%, with a sensitivity of 85.7% and specificity of 75.0%. This was significantly superior to predictions using clinical covariates alone, which exhibited an area under the ROC curve of 0.57 (p < 0.008).InterpretationThis study provides the first multi‐institutional, multimodal connectomic prediction algorithm for VNS, and provides new insights into its mechanism of action. Reliable identification of VNS responders is critical to mitigate surgical risks for children who may not benefit, and to ensure cost‐effective allocation of health care resources. ANN NEUROL 2019;86:743–753
Theoretical studies of new Schiff base ligand derived from 1,3‐diaminopropane and 2‐acetyl ferrocene and studying some applications of its metal complexes
Authors: Sayed Fatma N. , Mahmoud Walaa H. , Omar M.M. , Mohamed Gehad G. 
Published: August 2019

A novel bidentate Schiff base ligand (L) and some d‐transition metal chelates (Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II), Zn (II) and Cd (II)) were synthesized and characterized using various physicochemical and spectroscopic techniques like elemental analysis, IR, mass, UV–visible and thermal analysis. The spectroscopic data suggested that the parent Schiff base ligand coordinated to the metal ions through both imine nitrogen atoms. The molecular and electronic structure of the free ligand was optimized theoretically, and the quantum chemical parameters were calculated. The molecular structure can be used to investigate the coordination sites and the total charge density around each atom. The free ligand and its complexes were screened for their antimicrobial activities for various pathogenic bacteria and fungi. The anticancer activities of the free ligand, Cr (III), Mn (II) and Fe (III) complexes were screened against MCF‐7 cell line and found that Mn (II) complex has the lowest IC50 (15.90 μg/ml). Molecular docking was used to predict the binding between the free ligand with receptor of mutant human androgen (ARccr) derived from androgen‐independent prostate cancer (1GS4), crystal structure of yeast‐specific serine/threonine protein phosphatase (ppz1) of Candida Albicans (5JPE) and crystal structure of renal tumor suppressor protein, folliculin (3 V42) and to identify the binding mode and the crucial functional groups interacting with the three proteins.
Two novel d10 transition metal complexes based on 1H‐benzimidazole‐5,6‐dicarboxylic acid: Synthesis, structure and multifunctional luminescence detection
Authors: Liu Chun‐Hong , Xing Shang‐Hua , Zhou Jun , Bai Feng‐Ying , Xing Yong‐Heng 
Published: August 2019

Two new coordination complexes based on benzimidazole dicarboxylic acid, Zn(Hbidc)⋅H2O (1) and Cd(Hbidc)(H2O) (2), have been synthesized under hydrothermal conditions. The complexes were characterized using elemental analysis, infrared and UV–visible spectroscopies, powder X‐ray diffraction, thermogravimetry and single‐crystal X‐ray diffraction. Structural analyses showed that the crystal structures of 1 and 2 are different, due to the various modes of linking of the benzimidazole dicarboxylic acid. Complex 1 has a two‐dimensional network structure and 2 has a three‐dimensional network structure. In addition, we studied the performance of the fluorescence response of two complexes. Results showed that the complexes can be used as chemical sensors for multifunctional testing, such as for UO22+, xanthine and Fe3+ ions. Even if the concentration is very low, they could also be detected, showing that coordination complexes 1 and 2 have very high fluorescence sensitivity. The detection limit for UO22+ is 5.42 nM (1) and 0.02 nM (2), that for xanthine is 1.37 nM (1) and 0.28 nM (2), and that for Fe3+ ions is 0.76 nM (1) and 0.62 nM (2).
Victim body mutilation in sexual homicides: Exploring Chinese sexual homicide cases
Authors: Chan Heng Choon (Oliver) , Li Feng 
Published: August 2019

AbstractLittle exists beyond medicolegal case reports on victim mutilation homicides, much less on those occurring in the context of sexual homicides. As limited information is available on sexual homicides that occurred in China, this study aims to explore the offending characteristics of sexual homicide offenders (SHOs) who mutilated their victims and to compare their modus operandi with non‐mutilation sexual murderers. The offender, victim, and offense characteristics of 82 sexual homicide cases (i.e., 31 mutilation and 47 non‐mutilation cases; 1988–2018), derived from police data of three regions and published case reports, were examined. In addition to the descriptive offender and victim characteristics of Chinese SHOs who performed victim body mutilation, findings indicate that offenders who mutilated their victims were more likely than those who did not mutilate the victim to have a previous sexual offense conviction. They were motivated primarily by sex and least motivated by financial gain. Victim abduction prior to the offense was more frequently reported in non‐mutilation sexual murders. These findings may offer some insights for police who need to prioritize their investigative strategies in cases of sexual homicide with victim mutilation.
A review on transcriptional regulation responses to hypoxia in mesenchymal stem cells
Authors: Alijani Najva , Johari Behrooz , Moradi Mohammad , Kadivar Mehdi 
Published: August 2019

AbstractMesenchymal stem cells (MSCs), which are known for having therapeutic applications, reside in stem cell niches where the oxygen concentration is low. At the molecular level, the master regulator of the cellular reaction to hypoxia is hypoxia‐inducible transcription factor (HIF). The transcriptional response of a cell to hypoxia is affected by two major components; first, the structure of hypoxia‐response elements (HREs), which primarily define how much of the HIF signal is integrated into the transcriptional output of individual genes. Second, the availability of other transcriptional factors cooperating with HIF in the context of HRE.In MSCs, the expression of a single gene by hypoxia depends on elements such as factors influencing the HIF activity, metabolic pathways, the real oxygen concentration in the cellular microenvironment, and duration of culture. In addition, specific growth factors and pro‐infection cytokines, hormones, oncogenic signaling, as well as ultrasound are potent regulators of HIF in MSCs. Altogether, the response of MSCs to hypoxia is complex and mediated by several genes and molecular agents. Regarding the influence of hypoxia on MSCs, oxygen concentration must be taken into consideration based on the cell type and the aim of culture before a particular MSCs culture.
MicroRNA‐140‐5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21‐activated kinase 4
Authors: Peng Min , Pang Chunyan 
Published: August 2019

AbstractOral squamous cell carcinoma (OSCC) is a serious global health problem. Recently, accumulating microRNA (miRNA) has emerged as crucial players in the development and progression of carcinomas including OSCC. Our study aimed to further investigate the roles of miR‐140‐5p in OSCC tumorigenesis and related molecular basis. In this study, OSCC tissues and adjacent normal tissues were isolated from 34 OSCC patients who suffered from surgical resection at our hospital. MiR‐140‐5p level was measured by reverse‐transcription quantitative polymerase chain reaction assay. p21‐activated kinase 4 (PAK4) protein level was determined by western blot assay in OSCC cells at 48 h posttransfection or OSCC xenograft tumors at day 35 after OSCC cell injection. The cell proliferative ability was assessed by cell counting kit‐8 assay in OSCC cells at 0, 24, 48, 72 h after transfection. Cell apoptosis and cell‐cycle analysis was conducted using a flow cytometry in OSCC cells at 48 h after transfection. The interaction between miR‐140‐5p and PAK4 3′‐untranslated region was tested by bioinformatics analysis and luciferase reporter assay in OSCC cells at 48 h after transfection. Mouse xenograft models of OSCC were established to examine the influence of miR‐140‐5p on OSCC tumorigenesis in vivo during 35 days after OSCC cell injection. Our data showed that miR‐140‐5p expression was notably downregulated in OSCC tissues and cell lines. MiR‐140‐5p inhibited the expression of PAK4 by direct interaction in OSCC cells. Functional analysis disclosed that miR‐140‐5p overexpression or PAK4 knockdown suppressed cell proliferation, promoted cell apoptosis, and induced cell‐cycle arrest in OSCC. Moreover, PAK4 upregulation rescued the detrimental effects of miR‐140‐5p on cell proliferation and cell‐cycle progression and hampered cell apoptosis induced by miR‐140‐5p in OSCC. In vivo experiments demonstrated that miR‐140‐5p overexpression suppressed the growth of OSCC xenograft tumors by downregulating PAK4. In conclusion, our data revealed miR‐140‐5p suppressed OSCC tumorigenesis by targeting PAK4 in vitro and in vivo, deepening our understanding on the function and molecular basis of miR‐140‐5p in the development of OSCC.
A case of severe hypothyroidism due to lenalidomide
Authors: Blair Rachel A. , Leaf Rebecca Karp , Leaf David E. 
Published: August 2019

AbstractLenalidomide, an immunomodulatory drug often used to treat multiple myeloma, can cause hypo‐ or hyperthyroidism. We present a patient being treated with lenalidomide for 2 years who developed severe hypothyroidism that was complicated by rhabdomyolysis and acute kidney injury. Thyroid function tests should be serially monitored in patients taking lenalidomide.
Large cyst of the vaginal wall in pregnancy
Authors: Papapanagiotou Ioannis K. , Chatzipapas Ioannis , Koutroumanis Pelopidas , Marinopoulos Spyridon , Thomakos Nikolaos , Brozou Maria , Ntzeros Konstantinos , Petrakis Evangelos , Diakosavvas Michalis , Fasoulakis Zacharias , Morphopoulos George , Loutradis Dimitrios 
Published: August 2019

AbstractLarge vaginal cysts during pregnancy are rare and can mislead Obstetricians to a false diagnosis, that of “Protruding membranes”. Aspiration of the cyst can be easily performed, resulting in the collapsing of the cyst and an uneventful vaginal delivery can be conducted.
A Guanidyl‐Based Bivalent Peptidomimetic Inhibits K‐Ras Prenylation and Association with c‐Raf
Authors: Tsubamoto Mai , Le Toan Khanh , Li Minghua , Watanabe Taku , Matsumi Chiemi , Parvatkar Prakash , Fujii Hiroshi , Kato Nobuo , Sun Jiazhi , Ohkanda Junko 
Published: August 2019

AbstractUnusual lipid modification of K‐Ras makes Ras‐directed cancer therapy a challenging task. Aiming to disrupt electrostatic‐driven protein–protein interactions (PPIs) of K‐Ras with FTase and GGTase I, a series of bivalent dual inhibitors that recognize the active pocket and the common acidic surface of FTase and GGTase I were designed. The structure‐activity‐relationship study resulted in 8 b, in which a biphenyl‐based peptidomimetic FTI‐277 was attached to a guanidyl‐containing gallate moiety through an alkyl linker. Cell‐based evaluation demonstrated that 8 b exhibited substantial inhibition of K‐Ras processing without apparent interference with Rap‐1A processing. Fluorescent imaging showed that 8 b disrupts localization of K‐Ras to the plasma membrane and impairs interaction with c‐Raf, whereas only FTI‐277 was found to be inactive. These results suggest that targeting the PPI interface of K‐Ras may provide an alternative method of inhibiting K‐Ras.
Chiral superstructures from homochiral Zn2+, Co2+, Fe2+‐2,6‐bis (aryl ethylimine)pyridine complexes
Authors: Dumitru Florina , van der Lee Arie , Barboiu Mihail 
Published: August 2019

AbstractWe report the hierarchical supramolecular organization of metallosupramolecular homochiral complexes 1‐Λ‐(S,S,S,S)‐M2+/1‐∆‐(R,R,R,R)‐M2+ and 2‐ Λ‐(S,S,S,S)‐M2+/2‐∆‐ (R,R,R,R)‐M2+ of M2+ = Co2+, Fe2+, Zn2+ metal ions with chiral pseudo‐terpyridine‐type ligands: 1‐(S,S) or 1‐(R,R) = 2,6‐bis (naphthyl ethylimine)pyridine and 2‐(S,S) or 2‐(R,R) = 2,6‐bis (phenyl‐ethylimine)pyridine. Circular dichroism measurements in solution were used to confirm the enantiomeric nature of all twelve complexes. For crystal structures of 1‐ Λ‐ (S,S,S,S)‐M2+ or 1‐∆‐ (R,R,R,R)‐M2+ complexes, absolute configurations {∆ (or P), Λ (or M)} were confirmed by refinement of the Flack parameter x: −0.007 ≤ x ≤ 0.11 for the single crystals of 1‐Λ‐(S,S,S,S)‐M2+/1‐∆‐ (R,R,R,R)‐M2+, 2‐ Λ‐ (S,S,S,S)‐Fe2+, and 2‐∆‐ (R,R,R,R)‐Co2+.
Practical method for increasing optical purity of cis‐verbenol
Authors: Kovalenko Vitaly , Krauchanka Aliaksei , Prokhorevich Konstantin 
Published: August 2019

AbstractR/S mixture of monoterpene alcohol cis‐verbenol can be separated in preparative scale by its conversion into phthalic mono‐ester and subsequent crystallization of its diastereomeric salts with (R)‐α‐methylbenzylamine and (S)‐α‐methylbenzylamine. Finally, basic methanolysis of the resolved phthalic mono‐esters results (S)‐cis‐verbenol and (R)‐cis‐verbenol in high enantiomeric and diastereomeric purity.
Single Droplet Mass Transfer Experiments for Acetic Acid Extraction with Triisooctylamine‐Based Solvents
Authors: Siebenhofer Matthäus , Grafschafter Annika 
Published: August 2019

AbstractSingle droplet mass transfer of acetic acid from aqueous phase into triisooctylamine‐based solvents modified with the Lewis basic modifier tributyl phosphate and the diluent Shellsol T was investigated for applicability in solvent design. Solvent composition of triisooctylamine‐based solvent mixtures has a decisive effect on liquid‐liquid partition of acetic acid. The modifier is needed to correct acid association of the ammonium salt, while the diluent mainly affects the viscosity, the density, and the interfacial tension of the solvent. The results show that single droplet mass transfer is controlled by solvent viscosity.