bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel canine circovirus strains from Thailand: Evidence for genetic recombination
Authors: Piewbang Chutchai , Jo Wendy K. , Puff Christina , van der Vries Erhard , Kesdangsakonwut Sawang , Rungsipipat Anudep , Kruppa Jochen , Jung Klaus , Baumgärtner Wolfgang , Techangamsuwan Somporn , Ludlow Martin , Osterhaus Albert D. M. E. 
Published: May 2018

AbstractCanine circoviruses (CanineCV’s), belonging to the genus Circovirus of the Circoviridae family, were detected by next generation sequencing in samples from Thai dogs with respiratory symptoms. Genetic characterization and phylogenetic analysis of nearly complete CanineCV genomes suggested that natural recombination had occurred among different lineages of CanineCV’s. Similarity plot and bootscaning analyses indicated that American and Chinese viruses had served as major and minor parental viruses, respectively. Positions of recombination breakpoints were estimated using maximum-likelihood frameworks with statistical significant testing. The putative recombination event was located in the Replicase gene, intersecting with open reading frame-3. Analysis of nucleotide changes confirmed the origin of the recombination event. This is the first description of naturally occurring recombinant CanineCV’s that have resulted in the circulation of newly emerging CanineCV lineages.
GBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application
Authors: Pajoumshariati Seyedramin , Shirali Hadi , Yavari Seyedeh Kimia , Sheikholeslami Sogol Naghavi , Lotfi Ghogha , Mashhadi Abbas Fatemeh , Abbaspourrad Alireza 
Published: May 2018

AbstractIn periodontics, osteoconductive biodegradable guided bone regeneration (GBR) membranes with acceptable physico-mechanical properties are required to fix alveolar bone defects. The objectives of the present study were to produce and characterize a novel co-polyester—poly (butylene succinate-co-glycolate) (PBSGL), and fabricate a PBSGL membrane by electrospinning. We then aimed to evaluate the in vitro effect of the glycolate ratio on the biocompatibility and osteogenic differentiation of mesenchymal stem cells (MSCs), and evaluate in vivo bone regeneration using these membranes in rabbit calvarial defects by histology. Increasing the glycolate ratio of electrospun PBSGL membranes resulted in better cell attachment, greater cell metabolic activity, and enhanced osteogenic potential at both transcriptional and translational levels. Histologic and histomorphometric evaluations revealed further that bone defects covered with fibers of higher glycolate ratios showed more bone formation, with no adverse inflammatory response. These results suggest that novel PBSGL electrospun nanofibers show great promise as GBR membranes for bone regeneration.
Endoscopic polymer injection and endoluminal plication in treatment of gastroesophageal reflux disease: evaluation of long-term results
Authors: De Moura Eduardo , Sallum Rubens , Nasi Ary , Coronel Martin , De Moura Diogo , De Moura Eduardo , Minata Mauricio , Cury Marcelo , Falcão Angela , Cecconello Ivan , Sakai Paulo 
Published: May 2018

Abstract
Background and study aims Us of proton pump inhibitors (PPIs) has made endoscopic treatment of gastroesophageal reflux disease (GERD) more efficient, with reduction in morbidity and complications. However, some patients persist with symptoms despite medical treatment and some are not compliant with it or cannot afford it for financial reasons, and thus they require non-pharmacological therapeutic options such as surgical fundoplication. Surgery may be effective in the short term, but there is related morbidity and concern about its long-term efficacy. The possibility of minimally invasive endoluminal surgeries has resulted in interest in and development of newly endoscopic devices. Good short-term results with surgical fundoplication lack of studies of is with long follow-up justify our interest in this study. The aim of this study was to investigate the efficacy of endoscopic polymer injection and endoluminal full-thickness plication in the long-term control of GERD.
Patients and methods Forty-seven patients with GERD who underwent an endoscopic procedure were followed up for 60 months and evaluated for total response (RT), partial response (RP) and no response (SR) to endoscopic treatment with reintroduction of PPIs.
Results Twenty-one patients received polymer injection (G0) and 26 endoluminal plication (G1). The number of patients with no response to endoscopic treatment with reintroduction of PPIs increased in time for both techniques (G0 P = 0.006; G1 P < 0.001). There was symptomatic improvement up to 12 months, with progressive loss of this trending up to 60 months in G0 and G1 (P < 0.001). Health-related quality of life score (GERD-HRQL) demonstrated TR in G0 and G1 at 1, 3, 6 and 12 months. The 60-month analysis showed an increased number of patients with SR in both groups. The quality of life assessment (SF-36) showed benefit in G0 up to 3 months. G0 showed a higher rate of complications. There were no deaths. There was healing of esophagitis at 3 months in 45 % of patients in G0 and 40 % in G1. There was no improvement in manometric or pH findings.
Conclusion Endoscopic therapies were ineffective in controlling GERD in the long term.
Endoscopic submucosal dissection of early gastric cancer via inverted overtube in a patient with situs inversus totalis: a case report
Authors: Miyaoka Youichi , Suemitsu Shinsuke , Fujiwara Aya , Kotani Satoshi , Tsukano Kosuke , Yamanouchi Satoshi , Kusunoki Ryusaku , Miyake Tatsuya , Fujishiro Hirofumi , Kohge Naruaki , Yamamoto Tomohiko , Amano Yuji 
Published: May 2018

Abstract
Background and study aims A 72-year-old man with complete situs inversus presented with early gastric cancer on the lesser curvature wall of the antrum of the stomach. Endoscopic submucosal dissection (ESD) was selected as a treatment. When the patient was positioned in the left decubitus position, the lesion was hidden by blood and gastric fluid because it was located on the gravitational side. Therefore, we decided to perform ESD with the patient in the right lateral decubitus position and use an inverted overtube, which provided a good endoscopic view without the need to rearrange the endoscopist, assistants, or endoscopic system. ESD was safe and feasible using the inverted overtube.
Konventionelle synthetische Immunsuppressiva (DMARDs) für die Therapie der nichtinfektiösen Uveitis
Authors: Tappeiner Christoph , Rath Thomas , Heiligenhaus Arnd 
Published: May 2018

ZusammenfassungDie Initialtherapie von Uveitiden besteht aus einer topischen und/oder systemischen Kortikosteroidgabe. Zur Erzielung von dauerhafter Reizfreiheit, Prophylaxe von uveitischen Sekundärkomplikationen, Kortisoneinsparung und Vermeidung von kortikosteroidbedingten unerwünschten Arzneimittelwirkungen ist im weiteren Verlauf nicht selten der Einsatz einer krankheitsmodifizierenden Therapie (sog. disease modifying antirheumatic drugs, DMARDs) notwendig. Dieser Beitrag soll eine strukturierte Übersicht über die wichtigsten konventionellen synthetischen DMARDs, deren Indikation, mögliche unerwünschte Arzneimittelwirkungen und das interdisziplinäre Monitoring vermitteln.
Katarakt bei Uveitis
Authors: Heiligenhaus Arnd , Walscheid Karoline , Pleyer Uwe 
Published: May 2018

ZusammenfassungEine häufige Komplikation bei Uveitis ist die Katarakt, deren Management anspruchsvoll sein kann. Die Operationsplanung setzt eine Kenntnis von Ursache (z. B. infektiös versus nichtinfektiös) und Verlauf der Uveitis voraus, einschließlich aller intraokularen Komorbiditäten (z. B. Makulaödem). Die präoperative Patientenselektion ist bei Uveitispatienten zum Erzielen guter Operationsergebnisse bei Uveitis besonders bedeutsam. Mit steroidsparenden krankheitsmodifizierenden antirheumatischen Medikamenten (DMARDs) kann die Rate postoperativer Komplikationen reduziert und das Visusergebnis verbessert werden. Vor der Operation muss eine stabile Entzündungskontrolle erzielt werden. Die Operation sollte minimalinvasiv erfolgen. Eine IOL-Implantation sollte nicht bei Patienten mit unvorhersehbarem Entzündungsverlauf erfolgen. Durch die Verwendung von intraokularen Kortikosteroiden (z. B. Dexamethason-Azetonid-Implantat, Triamcinolon-Azetonid) kann die Komplikationsrate reduziert werden. Postoperativ sollte die entzündungshemmende Medikation intensiviert und diese bis zu 3 Monate lang fortgesetzt werden. Bei sorgsamer Patientenauswahl, Planung und Durchführung der Kataraktoperation sowie postoperativer Nachsorge können bei Uveitispatienten zufriedenstellende anatomische und visuelle Operationsergebnisse erzielt werden.
Endocytoscopic findings of colorectal neuroendocrine tumors (with video)
Authors: Takeda Kenichi , Kudo Shin-ei , Misawa Masashi , Mori Yuichi , Yamano Miki , Inoue Haruhiro 
Published: May 2018

Abstract
Background and study aims Gastrointestinal neuroendocrine tumors (NET) are generally submucosal in location. Because these tumors are covered with normal mucosa, biopsy is necessary to confirm histological diagnosis before treatment. We explored the diagnostic capabilities of the endocytoscope, which can perform ultra-high magnification in vivo, for staining and diagnosing submucosal tumors in situ.
Self‐rated wellbeing and physical activity associations in European older adults
Authors: Peralta Miguel , Martins João , Gómez Chávez Francisco , Cortés Almanzar Paola , Marques Adilson 
Published: May 2018

AbstractBackground: Physical activity and self‐rated wellbeing have important benefits to health. However, scientific knowledge regarding their relationship among older adults is scarce. Thus, the aim of this study was to examine the associations between physical activity frequency and several dimensions of self‐rated wellbeing, in a representative sample of European older adults from 28 countries. Methods: This study is based on the European Social Survey round 6, 2012. It had a total sample size of 12,341 older adults (5100 men, 7241 women) with mean age 73.8 ± 6.6 years. Information was collected through a questionnaire, filled‐in during an hour‐long face‐to‐face interview. Physical activity was accessed using the question “On how many of the last 7 days you were physically active continuously for 20 minutes or longer?” and six dimensions of self‐rated wellbeing were used. Results: Physical activity in the last 7 days was linearly related with all dimension of the self‐rated wellbeing and with wellbeing total score for both sexes (men, β = 0.09, 95% CI: 0.07 to 0.10, p < .001; women, β = 0.10, 95% CI: 0.09 to 0.11, p < .001). Conclusions: Physical activity promotion should be stressed as a meaningful strategy to improve people's wellbeing overall. This strategy has special importance when considering the older adult population.
Half Wing N219 Aircraft Model Clean Configuration for Flutter Test On Low Speed Wind Tunnel
Authors: Syamsuar Sayuti , Sampurno Budi , Mahasti Katia Mayang , Sakti Pratama Muchamad Bayu , Sasongko Triyono Widi , Kartika Nina , Suksmono Adityo , Aji Saputro Mohamad Ivan , Eskayudha Dimas Bahtera 
Published: May 2018

Abstract
Flutter is a rapid self-feeding motion which is caused by the interaction of aerodynamic, structural and inertial forces. Flutter can cause major damage on aircraft structure which can lead to fatal accident in aviation. Several methods have been evolved to avoid the flutter phenomena occur during the flight envelope of aircraft design. On this study, method was developed by Indonesian Aerospace which consist of Finite Element Method (FEM) analysis, Ground Vibration Test (GVT), and Wind Tunnel Flutter Test (WTT). Based on the study, FEM have similar results toward to Wind Tunnel Flutter Test conjunction the clean configuration of N219 aircraft half wing model.
Trial production of fuel pellet from Acacia mangium bark waste biomass
Authors: Amirta R , Anwar T , Sudrajat  , Yuliansyah  , Suwinarti W 
Published: May 2018

Abstract
Fuel pellet is one of the innovation products that can be produced from various sources of biomass such as agricultural residues, forestry and also wood industries including wood bark. Herein this paper, the potential fuel pellet production using Acacia mangium bark that abundant wasted from chip mill industry was studied. Fuel pellet was produced using a modified animal feed pellet press machine equipped with rotating roller-cylinders. The international standards quality of fuel pellet such as ONORM (Austria), SS (Sweden), DIN (Germany), EN (European) and ITEBE (Italy) were used to evaluate the optimum composition of feedstock and additive used. Theresults showed the quality offuel pellet produced were good compared to commercial sawdust pellet. Mixed of Acacia bark (dust) with 10% of tapioca and 20% of glycerol (w/w) was increased the stable form of pellet and the highest heating value to reached 4,383 Kcal/kg (calorific value). Blending of Acacia bark with tapioca and glycerol was positively improved its physical, chemical and combustion properties to met the international standards requirement for export market. Based on this finding, production of fuel pellet from Acacia bark waste biomass was promising to be developed as an alternative substitution of fossil energy in the future.
Correcting mistakes in predicting distributions
Authors: Marot-Lassauzaie Valérie , Bernhofer Michael , Rost Burkhard 
Published: May 2018

Abstract

Motivation
Many applications monitor predictions of a whole range of features for biological datasets, e.g. the fraction of secreted human proteins in the human proteome. Results and error estimates are typically derived from publications.

Results
Here, we present a simple, alternative approximation that uses performance estimates of methods to error-correct the predicted distributions. This approximation uses the confusion matrix (TP true positives, TN true negatives, FP false positives and FN false negatives) describing the performance of the prediction tool for correction. As proof-of-principle, the correction was applied to a two-class (membrane/not) and to a seven-class (localization) prediction.

Availability and implementation
Datasets and a simple JavaScript tool available freely for all users at http://www.rostlab.org/services/distributions.

Supplementary information
Supplementary data are available at Bioinformatics online.
Difficult-to-Treat Resistance in Gram-negative Bacteremia at 173 US Hospitals: Retrospective Cohort Analysis of Prevalence, Predictors, and Outcome of Resistance to All First-line Agents
Authors: Kadri Sameer S , Adjemian Jennifer , Lai Yi Ling , Spaulding Alicen B , Ricotta Emily , Prevots D Rebecca , Palmore Tara N , Rhee Chanu , Klompas Michael , Dekker John P , Powers John H , Suffredini Anthony F , Hooper David C , Fridkin Scott , Danner Robert L ,   National Institutes of Health Antimicrobial Resistance Outcomes Research Initiative (NIH–ARORI)
Published: May 2018

Abstract

Background
Resistance to all first-line antibiotics necessitates the use of less effective or more toxic “reserve” agents. Gram-negative bloodstream infections (GNBSIs) harboring such difficult-to-treat resistance (DTR) may have higher mortality than phenotypes that allow for ≥1 active first-line antibiotic.

Methods
The Premier Database was analyzed for inpatients with select GNBSIs. DTR was defined as intermediate/resistant in vitro to all ß-lactam categories, including carbapenems and fluoroquinolones. Prevalence and aminoglycoside resistance of DTR episodes were compared with carbapenem-resistant, extended-spectrum cephalosporin-resistant, and fluoroquinolone-resistant episodes using CDC definitions. Predictors of DTR were identified. The adjusted relative risk (aRR) of mortality was examined for DTR, CDC-defined phenotypes susceptible to ≥1 first-line agent, and graded loss of active categories.

Results
Between 2009–2013, 471 (1%) of 45011 GNBSI episodes at 92 (53.2%) of 173 hospitals exhibited DTR, ranging from 0.04% for Escherichia coli to 18.4% for Acinetobacter baumannii. Among patients with DTR, 79% received parenteral aminoglycosides, tigecycline, or colistin/polymyxin-B; resistance to all aminoglycosides occurred in 33%. Predictors of DTR included urban healthcare and higher baseline illness. Crude mortality for GNBSIs with DTR was 43%; aRR was higher for DTR than for carbapenem-resistant (1.2; 95% confidence interval, 1.0–1.4; P = .02), extended-spectrum cephalosporin-resistant (1.2; 1.1–1.4; P = .001), or fluoroquinolone-resistant (1.2; 1.0–1.4; P = .008) infections. The mortality aRR increased 20% per graded loss of active first-line categories, from 3–5 to 1–2 to 0.

Conclusion
Nonsusceptibility to first-line antibiotics is associated with decreased survival in GNBSIs. DTR is a simple bedside prognostic measure of treatment-limiting coresistance.
Sunspot drawings by Japanese official astronomers in 1749–1750
Authors: Hayakawa Hisashi , Iwahashi Kiyomi , Fujiyama Masashi , Kawai Toshiki , Toriumi Shin , Hotta Hideyuki , Iijima Haruhisa , Imada Shinsuke , Tamazawa Harufumi , Shibata Kazunari 
Published: May 2018

AbstractSunspot observations with telescopes in the 18th century were carried out in Japan as well as elsewhere. One of these sunspot observations is recorded in an account called Sansaizusetsu narabini Kansei irai Jissoku Zusetsu (Charts of Three Worlds and Diagrams of Actual Observations since Kansei Era). We have analyzed manuscripts of this account to show a total of 15 sunspot drawings during 1749–1750. These observations are considered to be carried out by contemporary official astronomers in Japan, with telescopes covered by zongurasus (&lt; zonglas in Dutch, corresponding to “sunglass” in English). We counted their group number of sunspots to locate them in long-term solar activity and show that their observations were situated near the solar maximum in 1750. We also computed their locations and areas, while we have to admit differences of the variant manuscripts with one another. These observational records show the spread of sunspot observations not only in Europe, but also in Japan, and hence may contribute to crosscheck, or possibly to improve the known sunspot indices.
Sun navigation requires compass neurons inDrosophila
Authors: Giraldo Ysabel Milton , Leitch Katherine J. , Ros Ivo K. , Warren Timothy L. , Weir Peter T. , Dickinson Michael H. 
Published: May 2018

AbstractTo follow a straight course, animals must maintain a constant heading relative to a fixed, distant landmark, a strategy termed menotaxis. In experiments using a flight simulator, we found thatDrosophilaadopt arbitrary headings with respect to a simulated sun, and individuals remember their heading preference between successive flights—even over gaps lasting several hours. Imaging experiments revealed that a class of neurons within the central complex, which have been previously shown to act as an internal compass, track the azimuthal motion of a sun stimulus. When these neurons are silenced, flies no longer adopt and maintain arbitrary headings, but instead exhibit frontal phototaxis. Thus, without the compass system, flies lose the ability to execute menotaxis and revert to a simpler, reflexive behavior.One sentence summarySilencing the compass neurons in the central complex ofDrosophilaeliminates sun navigation but leaves phototaxis intact.
Walking Drosophila aim to maintain a neural heading estimate at an internal goal angle
Authors: Green Jonathan , Vijayan Vikram , Mussells Pires Peter , Adachi Atsuko , Maimon Gaby 
Published: May 2018

AbstractWhile navigating their environment, many animals track their angular heading via the activity of heading-sensitive neurons. How internal heading estimates are used to guide navigational behavior, however, remains largely unclear in any species. We found that normal synaptic output from heading neurons in Drosophila is required for flies to stably maintain their trajectory along an arbitrary direction while navigating a simple virtual environment. We further found that if the heading estimate carried by these neurons is experimentally redirected by focal stimulation, the fly typically turns so as to rotate this internal heading estimate back towards the initial angle, while also slowing down until this correction has been made. These experiments argue that flies compare an internal heading estimate with an internal goal angle to guide navigational decisions, highlighting an important computation underlying how a spatial variable in the brain is translated into navigational action.One Sentence SummaryFlies compare an internal heading estimate with an internal goal angle to guide navigation.
Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila
Authors: Barish Scott , Nuss Sarah , Strunilin Ilya , Bao Suyang , Mukherjee Sayan , Jones Corbin , Volkan Pelin C. 
Published: May 2018

SummaryIn Drosophila, 50 classes of olfactory receptor neurons (ORNs) connect to 50 class-specific and uniquely positioned glomeruli in the antennal lobe. Despite the identification of cell surface receptors regulating axon guidance, how ORN axons sort to form 50 stereotypical glomeruli remains unclear. Here we show that the heterophilic cell adhesion proteins, DIPs and Dprs, are expressed in ORNs during glomerular formation. Each ORN class expresses a unique combination of DIPs/dprs, with neurons of the same class expressing interacting partners, suggesting a role in class-specific self-adhesion ORN axons. Analysis of DIP/Dpr expression revealed that ORNS that target neighboring glomeruli have different combinations, and ORNs with very similar DIP/Dpr combinations can project to distant glomeruli in the antennal lobe. Perturbations of DIP/dpr gene function result in local projection defects of ORN axons and glomerular positioning, without altering correct matching of ORNs with their target neurons. Our results suggest that context-dependent differential adhesion through DIP/Dpr combinations regulate self-adhesion and sort ORN axons into uniquely positioned glomeruli.
Polymer brush bilayer at thermal equilibrium: A density functional theory approach
Authors: Edwards Mike John 
Published: May 2018

AbstractBy means of the density functional theory (DFT) framework, the longstanding problem of the polymer brush bilayers at thermal equilibrium is studied. The calculated density profiles reveal that the brushes balance compression and interpenetration when they come into contact. The equation of state of the polymer brush bilayers is obtained and it represents scaling of the pressure with molecular parameters and distance between substrates. The results of this study may shed light in our understanding of some severe Musculoskeletal diseases which degrade the synovium. The significance of this study lays on the fact that the molecular structure is investigated through fundamental physical laws. So, this study bridges between theoretical biological physics and medicine.