bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial
Authors: Porceddu Sandro Virgilio , Bressel Mathias , Poulsen Michael Geoffrey , Stoneley Adam , Veness Michael John , Kenny Lizbeth Moira , Wratten Chris , Corry June , Cooper Stephen , Fogarty Gerald Blaise , Collins Marnie , Collins Michael Kevin , Macann Andrew Martin John , Milross Christopher Gerard , Penniment Michael Gordon , Liu Howard Yu-hao , King Madeleine Trudy , Panizza Benedict James , Rischin Danny 
Published: March 2018

Purpose To report the results of the Trans Tasman Radiation Oncology Group randomized phase III trial designed to determine whether the addition of concurrent chemotherapy to postoperative radiotherapy (CRT) improved locoregional control in patients with high-risk cutaneous squamous cell carcinoma of the head and neck. Patients and Methods The primary objective was to determine whether there was a difference in freedom from locoregional relapse (FFLRR) between 60 or 66 Gy (6 to 6.5 weeks) with or without weekly carboplatin (area under the curve 2) after resection of gross disease. Secondary efficacy objectives were to compare disease-free survival and overall survival. Results Three hundred twenty-one patients were randomly assigned, with 310 patients commencing allocated treatment (radiotherapy [RT] alone, n = 157; CRT, n = 153). Two hundred thirty-eight patients (77%) had high-risk nodal disease, 59 (19%) had high-risk primary or in-transit disease, and 13 (4%) had both. Median follow-up was 60 months. Median RT dose was 60 Gy, with 84% of patients randomly assigned to CRT completing six cycles of carboplatin. The 2- and 5-year FFLRR rates were 88% (95% CI, 83% to 93%) and 83% (95% CI, 77% to 90%), respectively, for RT and 89% (95% CI, 84% to 94%) and 87% (95% CI, 81% to 93%; hazard ratio, 0.84; 95% CI, 0.46 to 1.55; P = .58), respectively, for CRT. There were no significant differences in disease-free or overall survival. Locoregional failure was the most common site of first treatment failure, with isolated distant metastases as the first site of failure seen in 7% of both arms. Treatment was well tolerated in both arms, with no observed enhancement of RT toxicity with carboplatin. Grade 3 or 4 late toxicities were infrequent. Conclusion Although surgery and postoperative RT provided excellent FFLRR, there was no observed benefit with the addition of weekly carboplatin.
Genetic Determinants for Leisure-Time Physical Activity
Authors: LIN XIAOCHEN , CHAN KATIE KEI-HANG , HUANG YEN-TSUNG , LUO XI , LIANG LIMING , WILSON JAMES , CORREA ADOLFO , LEVY DANIEL , LIU SIMIN 
Published: March 2018

ABSTRACT

Purpose
Leisure-time physical activity (LTPA) is a well-established modifiable lifestyle determinant for multiple cardiometabolic outcomes. However, current understanding of the genetic architecture that may determine LTPA remains very limited. Therefore, we aimed to examine the role of genetic factors in affecting LTPA, which has yet to be investigated comprehensively and in-depth.

Methods
We conducted a genomewide analysis using 1000 Genomes Project imputed data from the Women’s Health Initiative (n = 11,865), the Jackson Heart Study (n = 3015), and the Framingham Heart Study (n = 7339). A series of secondary analyses, including candidate gene analysis, sequence kernel association tests, pathway analysis, functional annotation, and expression quantitative trait loci analysis, were performed to follow-up on the primary findings.

Results
Ethnicity-specific genetic signals were investigated, respectively, for African Americans and European Americans. Two variants, rs116550874 (meta-analysis: P = 1.63 × 10−7) and rs3792874 (meta-analysis: P = 8.33 × 10−7), were associated with LTPA in African Americans; rs28524846 (meta-analysis: P = 1.30 × 10−6) was identified for EA. We also replicated four previously reported loci (GABRG3, CYP19A1, PAPSS2, and CASR; P for lead single nucleotide polymorphisms < 0.005). Further fine-mapping and functional annotation suggested that several identified loci (novel and replicated) are involved in 1) the homeostatic drive coupled with the reward system and 2) the development and regulation of the capacity to perform LTPA.

Conclusions
To our knowledge, our analysis is the first to comprehensively investigate the genomewide signals for LTPA in multiple ethnicities. These findings support the notion that genetic predisposition plays a critical role in determining LTPA, of which the biological and clinical implications warrants further investigation.
Pedestrian Space Characteristics Analysis on Kyai Tapa-KH. Hasyim Ashari Street Corridor, West Jakarta
Authors: Uniaty Quintarina 
Published: March 2018

The city of Jakarta shows special characteristics in social, economic and cultural structures, a characteristic of urban life that gives much influence to its physical form. Development of the city is faced with problem of environmental degradation caused by unbalanced provision of urban infrastructure and facilities against the heterogeneity of urban needs and activities. The services provided by municipal government are more often unable to keep up with increasing demands of society's needs. Urban spatial and specific facilities built to expect community activities in accordance with the facilities built.This paper aims to put forward the results of studies that have been done about public perception use of pedestrian and public space area at object study, the characteristics of user's activities area region object of research and empirical data about the problem of pedestrian path as part of a public space that is related to behavior of community activity. The research method is Descriptive Analysis as a research that suggests the phenomenon that occurs and see and seek interrelations. It is a combination of descriptive survey method with analytical survey method of a phenomenon. Case studies presented as an object of analysis at a later stage, to be able to better explain the facts found and influence between variables. Built environment as product and work in form of space, volume, structure, ornament; needed as a message representing the norms and values of society, perceptions and aspirations, including developing their motivations and expectations explicitly or implicitly. City life activities require pedestrian space adapted to the aspirations of its people, as an effort to humanize pedestrians into the pedestrian area planning as a spatial dimension in urban area physical development.
La indagación científica y la transmisión-recepción: una contrastación de modelos de enseñanza para el aprendizaje del concepto densidad
Authors: Florez-Nisperuza Elvira Patricia , De la Ossa Albis Andrés Fernando 
Published: March 2018

La indagación científica ha sido centro de atención de múltiples investigaciones en las últimas décadas; algunas respaldan y otras desacreditan su efectividad en el aprendizaje en relación con modelos de enseñanza más tradicionales como el de transmisión-recepción, que, para este estudio, se integran a prácticas de laboratorio coherentes con las respectivas metodologías. Este estudio tiene como objetivo principal determinar cuál de estas metodologías de la enseñanza tiene mayor influencia en el aprendizaje del concepto de densidad como propiedad de la materia en los niveles de conocimiento, comprensión y aplicación después de la intervención de cada estrategia, así como la indagación en el grupo experimental y la transmisión-recepción en el grupo de control. Por otra parte, se busca caracterizar los niveles de indagación alcanzados por los equipos conformados para realizar las prácticas de laboratorio del grupo sometido a dicho estrategia y relacionarlo con el aprendizaje. Para ello, se acude al paradigma cuantitativo de investigación y a un diseño cuasi-experimental de tipo transversal con pre y postest. Los resultados muestran de forma contundente que la indagación científica presenta mejores resultados en el aprendizaje del concepto en cuestión que la metodología de contraste con promedios de (10,59) y (8,18) respectivamente, corroborado estadísticamente por una prueba t que muestra un nivel de significancia de 0,017. Además, el equipo de laboratorio que presentó mejor nivel de indagación obtuvo también el mejor promedio en el postest; sin embargo, atípicamente el equipo con el desempeño más bajo en la indagación superó al resto de equipos en dicho promedio.
Typology and Representation of Alterations in Territorial Units: A Proposal
Authors: Goerlich Francisco , Ruiz Francisco 
Published: March 2018

Abstract
This article proposes a typology of boundary changes in territorial units at two points in time. The different types of changes are organized in a hierarchy and represented homogeneously, independently of the number of territorial units involved and of the changes to them. Each alteration is described precisely and unambiguously, and it is codified to allow the information to be treated automatically. In addition to providing efficient storage of the information about these changes, a canonical representation facilitates the automatic detection of inconsistencies in the database. At the same time, the typology allows us to define backward and forward equivalence rules, which helps in the task of generating homogeneous time series about territorial unit characteristics, such as population or surface area, or generating the full genealogy of a territorial unit over time. We also offer an application of the proposal to inconsistencies and error detection in the database Alterations to the Municipalities in the Population Censuses since 1842 from the Spanish National Statistical Institute (INE).
Components of Gini, Bonferroni, and Zenga Inequality Indexes for EU Income Data
Authors: Pasquazzi Leo , Zenga Michele 
Published: March 2018

Abstract
In this work we apply a new approach to assess contributions from factor components to income inequality. The new approach is based on the insight that most (synthetic) inequality indexes may be viewed as (weighted) averages of point inequality measures, which measure inequality between population subgroups identified by income. Assessing contributions of factor components to point inequality measures is usually an easy task, and based on these contributions it is straightforward to define contributions to the corresponding (synthetic) overall inequality indexes as well. As we shall show through an analysis of income data from Eurostat’s European Community Household Panel Survey (ECHP), the approach based on point inequality measures gives rise to readily interpretable results, which, we believe, is an advantage over other methods that have been proposed in literature.
An Analysis of Interviewer Travel and Field Outcomes in Two Field Surveys
Authors: Wagner James , Olson Kristen 
Published: March 2018

Abstract
In this article, we investigate the relationship between interviewer travel behavior and field outcomes, such as contact rates, response rates, and contact attempts in two studies, the National Survey of Family Growth and the Health and Retirement Study. Using call record paradata that have been aggregated to interviewer-day levels, we examine two important cost drivers as measures of interviewer travel behavior: the distance that interviewers travel to segments and the number of segments visited on an interviewer-day. We explore several predictors of these measures of travel - the geographic size of the sampled areas, measures of urbanicity, and other sample and interviewer characteristics. We also explore the relationship between travel and field outcomes, such as the number of contact attempts made and response rates.We find that the number of segments that are visited on each interviewer-day has a strong association with field outcomes, but the number of miles travelled does not. These findings suggest that survey organizations should routinely monitor the number of segments that interviewers visit, and that more direct measurement of interviewer travel behavior is needed.
Factor Structural Time Series Models for Official Statistics with an Application to Hours Worked in Germany
Authors: Weigand Roland , Wanger Susanne , Zapf Ines 
Published: March 2018

Abstract
We introduce a high-dimensional structural time series model, where co-movement between the components is due to common factors. A two-step estimation strategy is presented, which is based on principal components in differences in a first step and state space methods in a second step. The methods add to the toolbox of official statisticians, constructing timely regular statistics from different data sources. In this context, we discuss typical measurement features such as survey errors, statistical breaks, different sampling frequencies and irregular observation patterns, and describe their statistical treatment. The methods are applied to the estimation of paid and unpaid overtime work as well as flows on working-time accounts in Germany, which enter the statistics on hours worked in the national accounts.
The Yale Grammatical Diversity Project: Morphosyntactic variation in North American English
Authors: Zanuttini Raffaella , Wood Jim , Zentz Jason , Horn Laurence 
Published: March 2018

AbstractThe Yale Grammatical Diversity Project approaches the empirical domain of North American English from the perspective of generative microcomparative syntax. In addition to eliciting judgments from speakers of particular varieties, we also conduct large-scale surveys, map the results of those surveys geographically, conduct statistical tests taking geography and other social variables into account, and look for theoretically significant linguistic correlations. In all cases, we do this with the primary goal of understanding variation between speakers at the individual level. While our goals and methodologies are informed by our theoretical perspective, we expect that our work and results will be of interest to linguists working in other frameworks and even to the public more generally. This article outlines the goals and methodologies of the project and describes in broad strokes some of the results obtained so far, as well as some of the ways we have shared our findings with others, inside and outside academia.
Four- to five-year-olds’ use of word order and prosody in focus marking in Dutch
Authors: Chen Aoju , Höhle Barbara 
Published: March 2018

AbstractThis study investigated Dutch-speaking four- to five-year-olds’ use of word order and prosody in distinguishing focus types (broad focus, narrow focus, and contrastive narrow focus) via an interactive answer-reconstruction game. We have found an overall preference for the unmarked word order SVO and no evidence for the use of OVS to distinguish focus types. But the children used pitch and duration in the subject-nouns to distinguish focus types in SVO sentences. These findings show that Dutch-speaking four- to five-year-olds differ from their German- and Finnish-speaking peers, who show evidence of varying choice of word order to mark specific focus types, and use prosody to distinguish focus types in subject and object nouns in both SVO and OVS sentences. These comparisons suggest that typological differences in the relative importance between word order and prosody can lead to differences in children’s use of word order and prosody in unmarked and marked word orders. A more equal role of word order and prosody in the ambient language can stimulate more extensive use of prosody in the marked word order, whereas a more limited role of word order can restrict the use of prosody in the unmarked word order.
Pain, psychosocial tests, pain sensitization and laparoscopic pelvic surgery
Authors: Jarrell John , Robert Magali , Giamberardino Maria Adele , Tang Selphee , Stephenson Kirk 
Published: March 2018

Abstract

Background and aims:
Individuals with non-acute pain are challenged with variable pain responses following surgery as well as psychological challenges, particularly depression and catastrophizing. The purpose of this study was to compare pre- and postoperative psychosocial tests and the associated presence of sensitization on a cohort of women undergoing elective laparoscopic surgery for non-acute pain defined as pain sufficient for surgical investigation without persistent of chronic pain.

Methods:
The study was a secondary analysis of a previous report (Am J Obstet Gynecol 2014 Oct;211(4):360–8.). The study was a prospective cohort trial of 77 women; 61 with non-acute pain and 16 women for a tubal ligation. The women had the following tests: Pain Disability Index, Pain Catastrophizing Scale, CES-D (Center for Epidemiologic Studies Depression Scale) depression scale and the McGill Pain Scale (short form) as well as their average pain score and the presence of pain sensitization. All test scores were correlated together and comparisons were done using paired t-test.

Results:
There were reductions in pain and psychosocial test scores that were significantly correlated. Pre-operative sensitization indicated greater changes in psychosocial tests.

Conclusions:
There was a close association of tests of psychosocial status with average pain among women having surgery on visceral tissues. Incorporation of these tests in the pre- and postoperative evaluation of women having laparoscopic surgery appears to provide a means to a broader understanding of the woman’s pain experience.
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy
Authors: Min Sang-Won , Sohn Peter Dongmin , Li Yaqiao , Devidze Nino , Johnson Jeffrey R. , Krogan Nevan J. , Masliah Eliezer , Mok Sue-Ann , Gestwicki Jason E. , Gan Li 
Published: March 2018

Hyperacetylation of tau has been implicated in neurodegeneration and cognitive decline in tauopathy brains. The nicotinamide adenosine dinucleotide-dependent class-III protein deacetylase SIRT1 is one of the major enzymes involved in removal of acetyl groups from tauin vitro. However, whether SIRT1 regulates acetylation of pathogenic tau and ameliorates tau-mediated pathogenesis remains unclear. Here, we report deacetylating activity of SIRT1 for acetylated Lys174 (K174) of tau in tauP301S transgenic mice with a brain-specific SIRT1 deletion. We show that SIRT1 deficiency leads to exacerbation of premature mortality, synapse loss, and behavioral disinhibition in tauP301S transgenic mice of both sexes. By contrast, SIRT1 overexpression by stereotaxic delivery of adeno-associated virus that encodes SIRT1 into the hippocampus reduces acetylated K174 tau. Furthermore, SIRT1 overexpression significantly attenuates the spread of tau pathology into anatomically connected brain regions of tauP301S transgenic mice of both sexes. These findings suggest the functional importance of SIRT1 in regulating pathogenic tau acetylation and in suppressing the spread of tau pathologyin vivo.SIGNIFICANCE STATEMENTIn neurodegenerative disorders with inclusions of microtubule-associated protein tau, aberrant lysine acetylation of tau plays critical roles in promoting tau accumulation and toxicity. Identifying strategies to deacetylate tau could interfere with disease progression; however, little is known about how pathogenic tau is deacetylatedin vivo. Here we show that the protein deacetylase SIRT1 reduces tau acetylation in a mouse model of neurodegeneration. SIRT1 deficiency in the brain aggravates synapse loss and behavioral disinhibition, and SIRT1 overexpression ameliorates propagation of tau pathology.
IDENTIFIKASI SITUS KAPAL KARAM BERSEJARAH “KARANG PANJANG” DI PERAIRAN PULAU LAUT NATUNA
Authors: Dillenia Ira , Arief Troa Rainer 
Published: March 2018

Pulau Laut dan kawasan perairan Natuna secara keseluruhan berdasarkan bukti sejarah sejak abad 10 M, telah menjadi jalur lintas laut untuk berbagai kapal dagang asing yang akan masuk ke wilayah Nusantara. Dalam perjalanannya masuk ke Natuna, banyak dari armada kapal tersebut yang karam dan akhirnya tenggelam di kawasan perairan kepulauannya. Artinya, potensi keberadaan situs arkeologi bawah laut di kawasan ini sangat besar yang belum semuanya teridentifikasi. Karena itu, penelitian arkeologi maritim yang mendasari tulisan ini bertujuan mengidentifikasi bentuk dan struktur kapal karam, serta menggali nilai historis didalamnya. Fokus lokasi pada Situs Karang Panjang, Perairan Pulau Laut Natuna. Metode penelitian yang digunakan adalah survei akustik bawah air (side scan sonar), penyelaman, dan wawancara dengan masyarakat setempat. Hasil penelitian menunjukkan bahwa Situs Karang Panjang merupakan situs kapal karam bersejarah berteknologi mesin uap, struktur kapal berbahan campuran besi dan kayu dengan sebagian besar telah ditumbuhi karang sehingga telah menyatu dengan ekosistem bawah lautnya. Hal ini menjadikan Situs Karang Panjang berpotensi menjadi obyek wisata selam kapal karam (wreckdive) sebagai bagian gagasan Marine Eco-Archaeological Park di atas.
ANALISA HIDRO OSEANOGRAFI PULAU LIWUNGAN UNTUK STUDI KELAYAKAN STRUKTUR DERMAGA APUNG
Authors: Sufyan Agus , Akhwady Rudhy , Risandi Johan , Syadiah Nurfitri 
Published: March 2018

Kajian hidro oseanografi digunakan untuk menentukan lokasi penempatan dermaga apung yang sesuai di Pulau Liwungan Kabupaten Pandeglang-Jawa Barat. Dermaga apung di pulau tersebut nantinya akan digunakan sebagai pendukung kegiatan wisata bahari. Penggunaan dermaga apung dipilih karena mempunyai beberapa keunggulan dibandingkan dengan dermaga konvensional, utamanya dari segi biaya dan kemudahan pemasangan. Akan tetapi, dermaga jenis ini mememerlukan kondisi fisik perairan yang spesifik. Pada studi ini, dilakukan analisa terhadap faktor fisik perairan yang berpengaruh, yaitu kondisi gelombang dan pasang surut, melalui pengamatan lapangan dan pemodelan numerik dengan MIKE 21. Gelombang signifikan pada perairan Liwungan berkisar 1,1- 2 meter dengan rata-rata 1,8 m. Pasang surut mempunyai tinggi tunggang 1,66 meter, dengan tipe pasang surut campuran condong ke harian ganda. Hasil analisa menunjukkan letak perairan yang sesuai untuk penempatan dermaga apung berada di bagian tenggara pulau Liwungan dengan dasar perairan yang relatif lebih curam dengan kemiringan 8,5°. Lokasi tersebut relatif terlindung dari serangan gelombang dengan tinggi gelombang maksimum pada titik pemasangan dermaga apung hanya 1,35 meter (periode ulang 25 tahun).