bluuebunny/crossref_metadata_2025_split huggingface dataset:
МАРКЕТИНГ ВІДНОСИН ЯК СУЧАСНА КОНЦЕПЦІЯ МАРКЕТИНГУ
Authors: ВАСИЛЬЧЕНКО Олексій , ІЛЬЄНКО Андрій 
Published: December 2024

The article examines the concept of "relationship marketing" and provides its interpretation by scientists. The authors analyzed the stages of the evolution of relationship marketing in Ukraine from the initial attempts of its implementation to modern complex strategies based on the latest technologies and approaches. It is proven that relationship marketing marks a radical change in the paradigm of marketing worldview, which is characterized by the transition from competition and conflict to interdependence and cooperation, and new practices according to the principles of classical marketing tools are given. The work analyzes the main principles of relationship marketing, such as personalization (allows companies to better understand the needs and preferences of their customers), individual approach (the emphasis is on personal interaction with the customer), trust (formed through transparency, honesty and reliability in the company's interaction with customers) and communications (ensure constant communication between the company and clients). The differences between transactional marketing, which is aimed at ensuring a one-time sale from a large number of customers, and relationship marketing, which is aimed at encouraging repeat purchases from a certain pool of consumers, are presented. The path of customers is analyzed - from potential consumers to reliable consumers, some of whom, with active interaction with the company, will grow into partners of the company. The authors consider the role of technology and digital tools in the implementation of this concept, including the use of e-mail (with personalized letters companies can inform customers about new products, special offers and promotions, as well as remind them about important events or dates), social networks (allow not only to inform customers about new products and services, but also actively interact with them, receive feedback and build trusting relationships), customer relationship management (provide the opportunity to collect, store and analyze information about customers, their preferences, purchase history and interaction with the company). It also explores the benefits and challenges of moving to a relationship marketing model, and provides recommendations for businesses seeking to implement the concept.
Pengaruh Kualitas Produk, Harga, dan Citra Merek Terhadap Keputusan Pembelian Skincare Skintific Di E-Commerce Shopee
Authors: Ambarita Lilis Feronicha , Wasino Wasino 
Published: December 2024

Penelitian yang dilakukan bertujuan untuk menguji apakah keputusan pembelian dipengaruhi oleh kualitas produk, harga, dan citra merek. Pada saat ini skincare sangat digemari oleh kaum milenial, baik laki-laki maupun perempuan. Meningkatnya tingkat kepedulian terhadap diri sendiri membuat para generasi Z selalu memperhatikan kondisi kulit mereka dan merawat kulit dengan lebih hati-hati lagi. Dengan bertumbuhnya kesadaran masyarakat akan teknologi membuat banyak masyarakat memilih menggunakan teknologi untuk mempermudah proses jual beli, oleh sebab itu saat ini banyak masyarakat membeli skincare di E-commerce, masyarakat dapat memilih produk skincare apa yang mereka butuhkan, masyarakat dapat membandingan baik dari segi harga, bentuk, beragam varian warna dan tipe-tipe skincare tersebut. Riset penelitian telah terlaksana di bulan Juni-Juli 2024. Populasi yang digunakan adalah pembeli yang telah melakukan pembelian Skincare Skintific melalui E-commerce Shopee baik laki-laki maupun perempuan dengan jumlah yang tidak dapat ditentukan ataupun tidak terhingga. Total sampelnya yang digunakan dari penelitian ini menggunakan rumus Lameshow. Dalam penelitian ini metode yang digunakan yaitu metode deskriptif kuantitatif. Riset ini menggunakan 100 responden. Untuk sampel dan data didapatkan melalui kuesioner yang kemudian dianalisis menggunakan regresi linear berganda dengan bantuan SPSS 26. Hasil penelitian menyatakan bahwa kualitas produk tidak berpengaruh secara signifikan terhadap keputusan pembelian sementara hargatidak memiliki pengaruh signifikan terhadap keputusan dan citra merek memiliki pengaruh signifikan terhadap keputusan pembelian.
Pengaruh User Generated Content, Brand Image, dan Hedonic Value terhadap Minat Pembelian pada Produk Salted Egg Milea
Authors: Lawrence Lucas , Rochefort Thomas , Alwiyah Alwiyah , Millah Shofiyul 
Published: December 2024

Penelitian ini bertujuan untuk menguji pengaruh dari tiga faktor utama User Generated Content (UGC), Brand Image, dan Hedonic Value pada terhadap Purchase Intention konsumen terhadap produk Salted Egg Milea. Dalam era digital saat ini, penggunaan media sosial telah menjadi salah satu alat utama dalam pemasaran produk. UGC merupakan konten yang dibuat oleh pengguna untuk merekomendasikan atau merefleksikan pengalaman dengan produk tertentu, semakin menjadi perhatian dalam strategi pemasaran. Di sisi lain, citra merek juga dikenal sebagai persepsi konsumen tentang merek yang dapat mempengaruhi perilaku pembelian mereka. Penelitian ini menggunakan metode pendekatan kuantitatif dan data dikumpulkan melalui survei kepada 113 responden yang merupakan pengguna aktif media sosial dan memiliki pengetahuan tentang produk Salted Egg Milea. Teknik analisis data menggunakan Structural Equation Modeling (SEM) untuk menguji hubungan antara variabel-variabel yang diteliti. Hasil penelitian menunjukkan bahwa User Generated Content memiliki pengaruh positif dan signifikan terhadap niat pembelian produk Salted Egg Milea. Selain itu, citra merek juga terbukti memiliki pengaruh positif dan signifikan terhadap niat pembelian. Implikasi manajerial dari temuan ini adalah pentingnya memanfaatkan UGC dan membangun citra merek yang kuat untuk meningkatkan niat pembelian konsumen terhadap produk Salted Egg Milea. Penelitian ini memberikan kontribusi bagi pemahaman tentang pengaruh faktor-faktor ini dalam konteks pemasaran produk makanan dan minuman, khususnya produk salted egg.
فاعلية منصة قائمة على الذكاء الاصطناعي التوليدي والتلعيب في تنمية التفكير فوق المعرفي لدى طلاب التعليم العالي
Authors: أ.سلمان مطر السلمي  , د. أحمد بن إبراهيم فلاته  , أ.د. وليد بن سالم محمد الحلفاوي  
Published: December 2024

يهدف البحث الحالي إلى تصميم نموذج مقترح لمنصة إلكترونية قائمة على تكامل الذكاء الاصطناعي التوليدي وأدوات التلعيب وقياس فاعليتهما في تنمية التفكير فوق المعرفي لدى طلاب كلية الاتصال والاعلام بجامعة الملك عبدالعزيز . باستخدام المنهج شبه التجريبي، شملت الدراسة مجموعتين: الأولى درست باستخدام المنصة المدمجة بالذكاء الاصطناعي التوليدي وأدوات التلعيب، والثانية باستخدام المنصة دون تفعيل أدوات التلعيب. تكونت عينة الدراسة من ٦٠ طالبًا حيث تم تقسيمهم إلى مجموعتين بشكل عشوائي حيث بلغ عدد كل مجموعة (30) طالبًا. تم تطوير مقياس التفكير فوق المعرفي والذي تكون في نسخته النهائية، من (٣٢ ) بند موزعة على ثلاثة محاور: التخطيط، المراقبة والتحكم، التقويم. تم رصد النتائج وتحليلها إحصائياً باستخدام اختبار ( ت) لمقارنة المجموعات وتحديد دلالة الفروق بالإضافة الى حساب حجم الأثر. أظهرت النتائج فعالية المنصة الإلكترونية المقترحة التي تجمع بين الذكاء الاصطناعي التوليدي وأدوات التلعيب في تنمية التفكير فوق المعرفي لدى المجموعة التجريبية الأولى، مقارنةً بالمجموعة الثانية التي لم تستخدم سوى الذكاء الاصطناعي التوليدي. وأوصت الدراسة بضرورة دمج الذكاء الاصطناعي التوليدي مع أدوات التلعيب في بيئات التعلم الإلكترونية بهدف تطوير نواتج التعلم، وتنفيذ برامج ودورات تدريبية للمعلمين، تستهدف الاهتمام المعرفي بكيفية توظيف واستخدام بيئات التعلم القائمة على تكامل الذكاء الاصطناعي والتلعيب ومكوناتها المختلفة بالسياقات التعليمية.
The effects of cage on endplate collapse after stand-alone OLIF: based on finite element analysis and in vitro mechanics experiments
Authors: Li Hao , Liu Jiarui , Cui Huifei , Shen Nana , Wu Futong , Zhang Zhihao , Zhu Zhongze , Qiu Chensheng , Xiang Hongfei 
Published: December 2024

BackgroundLumbar degenerative diseases are an important factor in disability worldwide, and they are also common among the elderly population. Stand-Alone Oblique Lumbar Interbody Fusion (Stand-Alone OLIF) is a novel surgical approach for treating lumbar degenerative diseases. However, long-term follow-up after surgery has revealed the risk of endplate collapse associated with Stand-Alone OLIF procedures. This study aimed to investigate the effect of the cage factor on endplate collapse after Stand-Alone OLIF.MethodsFinite element (FE) models and calf lumbar functional units were established separately and used to simulate Stand-Alone OLIF surgery. On the L5 endplate of the FE model and the calf lumbar functional unit, 12 cage positions from anterior to posterior, 16 cage inclination angles from 0° to 15°, and 4 cage heights were selected to simulate surgical models with different cage positions. Compression loads of 400N were applied to the upper surface of the superior vertebral body of the cage, and 10Nm torques in four directions were used to simulate four different physiological movements of the lumbar spine: flexion, extension, lateral curvature and torsion, in order to compare the range of motion of the surgical segment and the endplate stress.ResultsWhen the cage is placed closer to the anterior and posterior edges of the endplate and when the height of the cage exceeds 12mm, the intervertebral range of motion at the surgical segment is greater and the stress on the endplate is higher during various lumbar spine activities. When the cage is inclined at an angle within 15°, there are no significant differences in the corresponding endplate stress and the range of motion.ConclusionFor Stand-Alone OLIF surgery, inserting the cage in the central anterior-posterior position of the intervertebral space and selecting a cage with a height not exceeding 12 mm can reduce the stress on the endplate after surgery, which is more conducive to the stability of the lumbar spine postoperatively and reduces the risk of postoperative endplate collapse. The inclination angle of the cage placement does not significantly affect postoperative endplate stress or lumbar stability.
Optimization of extraction in supercritical fluids in obtaining Pouteria lucuma seed oil by response surface methodology and artificial neuronal network coupled with a genetic algorithm
Authors: Chauca-Cerrutti Alex , Inga Marianela , Pasquel-Reátegui José Luis , Betalleluz-Pallardel Indira , Puma-Isuiza Gustavo 
Published: December 2024

When processing lucuma (Pouteria lucuma), waste such as shells and seeds is generated, which is a source of bioactive compounds. Recently, lucuma seed (LS), especially its oily fraction, has been studied for containing phytosterols and tocopherols, powerful antioxidants with health benefits. This study proposes lucuma seed oil (LSO) extraction using supercritical fluid (SCF) to improve the quality of the extract and minimize the environmental impact. LS was previously characterized, and the extraction parameters were optimized using a Box-Behnken design, considering temperature (40–60°C), pressure (100–300 bar), and CO2 flow rate (3–7 mL/min), applying the response surface methodology (RSM) and neural networks with genetic algorithm (ANN+GA). The optimal parameters were 45°C, 300 bar, and 6 mL/min, obtaining 97.35% of the total oil content. The RSM and ANN+GA models showed R2 values of 0.9891 and 0.9999 respectively, indicating that both models exhibited a good fit to the experimental data. However, ANN+GA provided a greater proportion of the total variability, which facilitates the identification of the optimal parameters for the extraction of oil from lucuma seeds. Compared to the Soxhlet method, the LSO obtained by SCF presented better acidity (4.127 mg KOH/g), iodine (100.294 g I2/100 g), and refraction indices (1.4710), as well as to a higher content of mono- and polyunsaturated fatty acids. Supercritical CO2 extraction is presented as a sustainable green alternative to Soxhlet extraction for extracting oil from lucuma seed due to its high extraction efficiency and similar fatty acid profile.
Subclinical/overt hypothyroidism may be associated with diminished ovarian reserve in infertile women independent of thyroid autoimmunity
Authors: Zhang Hongzhan , Qiu Han , Liu Zhiqiang , Wu Yulian , Liu Wei , Huang Chunyu 
Published: December 2024

ObjectiveTo investigate the association between thyroid dysfunction or thyroid autoimmunity (TAI) and diminished ovarian reserve (DOR).MethodsA total of 2,867 women undergoing their first in-vitro fertilization (IVF) cycle at Shenzhen Zhongshan Obstetrics &amp; Gynecology Hospital between January 1, 2013 and June 30, 2021, were enrolled in this study. The participants had documented thyroid and ovarian reserve metrics. They were categorized into three groups based on their thyroid function: normal thyroid function (N = 2,540), subclinical/overt hypothyroidism (SCH/OH) (N = 290), and subclinical/overt hyperthyroidism (N = 37). Anti-Mullerian hormone (AMH) and antral follicle count (AFC) were assessed and collected. Women with AMH &lt;1.2 ng/mL and AFC &lt; 5 were diagnosed with DOR. Basic characteristics and ovarian reserve-related parameters were compared among the three groups. The association between thyroid function and ovarian reserve function was further analyzed using logistical regression analyses. In addition, the euthyroid population was stratified using a thyroid-stimulating hormone (TSH) threshold of 2.5 µIU/mL, and the ovarian reserve-related parameters were compared among women with low-normal TSH (TSH &lt; 2.5 µIU/mL), high-normal TSH (2.5 µIU/mL ≤ TSH ≤ 4.2 µIU/mL) and SCH/OH.ResultsWomen with SCH/OH had lower AMH levels (2.79 ng/mL vs. 3.41 ng/mL, P &lt; 0.001) and a significantly higher prevalence of AMH level &lt; 1.2ng/mL (17.2% vs. 12.1%, P = 0.015) compared to those with normal thyroid function. The prevalence of DOR was also higher among women with SCH/OH (10.0% vs. 6.5%, P = 0.036). There were no significant differences in ovarian reserve between women with normal thyroid function and those with subclinical/overt hyperthyroidism. Logistic regression analyses showed that the odds ratio (OR) of women with SCH/OH suffering from DOR was 1.666 (95% CI: 1.079-2.572) compared to those with normal thyroid function, after adjusting for TAI status and basic clinical characteristics. When the euthyroid group was stratified according to TSH levels, women with SCH/OH showed significantly lower AMH levels compared to women with low-normal TSH (2.79 ng/mL vs. 3.44 ng/mL, P &lt; 0.001) and a significantly higher prevalence of DOR (10.0% vs. 6.0%, P = 0.010). Logistic regression analyses showed that the women with SCH/OH had an increased prevalence of DOR (OR: 1.819, 95% CI: 1.158-2.858) compared to those with low-normal TSH, after adjusting for TAI status and basic clinical characteristics. However, the OR for DOR among women with high-normal TSH was not significantly elevated compared to those with low-normal TSH (OR: 1.310, 95% CI: 0.936-1.832).ConclusionSCH/OH may be associated with DOR, irrespective of TAI status.
Two rare cases of severe community-acquired bloodstream infections: a clinical case report
Authors: Meng Li-Na , Li Gang 
Published: December 2024

BackgroundThe escalating demographic shift towards an aging population and the widespread occurrence of immunological diseases have contributed to an elevation in the frequency of community-acquired infections. Notably, among these infections, community-acquired bloodstream infections (CABSI) stand out due to their significant lethality. Detailed medical history inquiries, assessment of underlying immune status, detection of the source of infection, and initial precise identification and treatment of the infectious agents can improve the prognosis of CABSI.Case descriptionIn this paper, two incidences of severe CABSI with insidious onset and rapid progression are described. Both patients had compromised basic immunity: one developed the infection following unhygienic dietary practices, and the other after repeated enemas leading to intestinal damage. Blood genomic sequencing revealed the presence of Klebsiella pneumoniae and Staphylococcus aureus in the respective cases, with the origin of the infection traced back to the gastrointestinal tract. Both patients experienced positive outcomes following targeted antibiotic therapy, fluid resuscitation, support for organ function, and surgical interventions. Nevertheless, one patient manifested dry gangrene in the extremities during the course of treatment, potentially associated with the administration of vasoconstrictor drugs, considering the compromised baseline vascular conditions.ConclusionClinicians are advised to expeditiously uncover concealed medical histories and potential sources of infection in patients, thoroughly investigate the origin of the infection, and initiate early genomic testing to ascertain the specific nature of the infection. This proactive approach aims to facilitate precise treatment strategies and, consequently, enhance the overall prognosis.
PgRNA closely correlates to cytokine profile in HBeAg-positive pregnant women undergoing prophylactic antiviral intervention
Authors: Tang Qiao , Wang Chunrui , Li Hu , Chen Zhiwei , Liu Xiaoqing , Xue Yunling , Qiu Yue , Zeng Yi , Hu Peng 
Published: December 2024

BackgroundPrevious studies primarily focused on the effects of ALT and virology, but there is a lack of research on the correlations of HBcrAg and pgRNA, two novel virologic markers, with immunological parameters in pregnant women with CHB undergoing prophylactic antiviral intervention.MethodsWe conducted a retrospective cohort study involving 28 HBeAg-positive pregnant women with CHB undergoing prophylactic antiviral intervention. Clinical data, virological markers (HBV DNA, HBsAg, HBeAg, HBcrAg and pgRNA) and 28 cytokines were detected at three time points: 24-28 weeks gestation (before prophylactic antiviral intervention), near birth and within 3 months postpartum.ResultsPgRNA was moderately (correlation coefficient between 0.4 and 0.6) positively correlated with Th1-type cytokines (IFN-γ, IL12p70, IL2, and TNF-α), Th17-type cytokines (IL21), Th2-type cytokines (IL10, IL4, and IL5), and cytokines regulating cell proliferation and differentiation (CTLA4, IL15, IL23, and TGF-β1) and moderately negatively correlated with EGF (correlation coefficient = -0.4), while ALT, HBV-DNA, HBsAg and HBcrAg were insignificantly correlated with cytokines at 24-28 weeks of gestation. Most cytokines tended to be elevated, with statistically significant increases observed only for the chemokines IP10 and MCP-1 during pregnancy. Most cytokines were significantly increased in postpartum women with virologic rebound after treatment discontinuation postpartum, but no significant change in the Th1/Th2 ratio. Changes in virologic markers were significantly correlated with cytokines. Immune activation was more pronounced in postpartum women who developed ALT flare compared to who did not, with Th1-type cytokines (especially IL12p40) and chemokines being main differential cytokines.ConclusionPgRNA was more closely correlated with cytokine profiles, and postpartum ALT flare may be the result of the interaction between Th1-type cytokines and chemokines.
A survey of attitudes towards the curriculum for clinical medicine postgraduates pursuing professional master’s degrees: perspectives of supervisors and students
Authors: Xu Rui , Wu Jing , Jin Xin , Tang Min , Pang Caishuang , Yang Zhu , Yu Huarong 
Published: December 2024

BackgroundBased on the recommendation of the Ministry of Education in China to differentiate between “academic” and “professional” degrees, medical schools offer both professional and academic degrees for postgraduates. In China, clinical postgraduates who are pursuing a professional master’s degree also participate in standardised residency training (SRT). However, little attention has been given to feedback from students and supervisors regarding postgraduate curricula.MethodsAn online questionnaire was designed for clinical postgraduates with professional master’s degrees and their supervisors at Chongqing Medical University (CQMU), China. A total of 544 questionnaires from postgraduates and 220 questionnaires from supervisors were included for analysis.ResultsRegarding the positive effect of public courses on professional research, 20.04% of clinical professional master’s degree students reported “a significant positive effect.” Compared with public courses, more postgraduates (33.46%) reported that professional courses had a “significant positive effect” on clinical work (χ2 = 25.00, p &lt; 0.05). A total of 49.64% of respondents with clinical professional master’s degrees reported at least some repetition between postgraduate public courses and undergraduate courses. Of the postgraduates, 47.43% preferred online learning for public courses, whereas supervisors tended to prefer mixed online and offline learning. A total of 66.73% of postgraduates and 64.55% of supervisors suggested that public alternative courses should be offered to meet the needs of postgraduates. “Mental and health emotion management” and “employment and entrepreneurship guidance” were the public alternative courses that were most strongly preferred by both postgraduates and supervisors. With respect to improvements in self-knowledge and ability through different forms of professional learning, the responses of postgraduates and supervisors differed. According to postgraduates, the most effective type of learning was “participation in research projects,” whereas supervisors believed that “professional courses” were the most effective.ConclusionThere are differences between clinical postgraduates pursuing professional master’s degrees and their supervisors in terms of attitudes towards public and professional curricula. The results of this study may provide guidance to improve public and professional curricula for clinical professional master’s degree students.
Association of perioperative initiation of gabapentin versus pregabalin with kidney function: a target trial emulation study
Authors: He Yanfang , Mo Liqian , Li Juan , Lu Dongying , Niu Jinlei , Li Ying , Zeng Qiying , Gao Yueming 
Published: December 2024

BackgroundGabapentinoids, such as gabapentin and pregabalin, are opioid substitutes commonly included in perioperative multimodal analgesia regimens. We investigated whether the initiation of gabapentin and pregabalin during the perioperative period have varying effects on the adverse renal outcomes.MethodsThis study included adult participants who received surgery in the INSPIRE database. The exposure of interest was the initiation of pregabalin or gabapentin during the perioperative period. The primary outcome was renal function decline. Secondary outcomes included incident chronic kidney disease (CKD), hospital-acquired acute kidney injury (AKI), and in-hospital mortality. We conducted a propensity score to balance the baseline characteristics. Cox proportional hazard regression was used to estimate the hazard ratio (HR) of the initiation of gabapentin compared with pregabalin.ResultsAmong 640 pairs of pregabalin and gabapentin initiators in the matched cohort, the initiation of gabapentin was associated with a higher risk of kidney function decline (HR, 1.40; 95% confidence interval [CI], 1.04–1.89) as compared with pregabalin. After excluding participants who were diagnosed with CKD at the baseline, the initiation of gabapentin was associated with a higher risk of incident CKD (HR, 1.46; 95% CI, 1.03–2.05) as compared with pregabalin. For the in-hospital outcomes, the proportion of AKI and mortality were similar between participants initiating gabapentin and pregabalin. In addition, the risk of kidney function decline did not vary across each subgroup.ConclusionThe initiation of gabapentin during the perioperative period was associated with a higher risk of kidney function decline and incident CKD as compared with pregabalin.