bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum levels of oxidative stress marker malondialdehyde in breast cancer patients in relation to pathohistological factors, estrogen receptors, menopausal status, and age
Authors: Gubaljevic Jasmina , Srabović Nahida , Jevrić-Čaušević Adlija , Softić Adaleta , Rifatbegović Adi , Mujanović-Mustedanagić Jasminka , Dautović Esmeralda , Smajlović Aida , Mujagić Zlata 
Published: March 2019

Introduction: The aim of this study was to determine the serum levels of malondialdehyde (MDA) in patients with invasive breast cancer in relation to its serum levels in patients with benign breast disease, and to investigate correlation between MDA serum levels with pathohistological prognostic factors (tumor size, lymph node involvement, and histologic grade [HG]), estrogen receptor (ER) status, and with breast cancer patient’s age and menopausal status.
Methods: A total of 43 with well-documented invasive breast cancer were included in this study: 27 with positive axillary’s lymph nodes, and 16 with negative axillary’s lymph nodes, and 39 patients with findings of benign breast diseases. MDA determination in serum of breast cancer and benign breast disease patients was performed by the fluorimetric method, immunohistochemical staining was performed for ER, and routine pathohistological examination was conducted for pathohistological factors.
Results: MDA serum levels in breast cancer patients were significantly higher than MDA serum levels in benign breast disease patients (p = 0.042). No statistically significant difference between MDA serum levels in breast cancer patients with and without lymph node metastases was found (p = 0.238). No statistically significant correlations between MDA serum levels and tumor size (p = 0.256), HG (p = 0.124), or number of positive lymph nodes (0.113) were found. A statistically significant correlation between serum MDA levels and ages of breast cancer patients with lymph node metastases was found (p = 0.006).
Conclusion: Obtained results support the importance of MDA in the carcinogenesis of breast cancer. According to our findings, serum level of MDA could not be a useful prognostic factor in breast cancer.
O acesso à justiça e o mínimo existencial: a assessoria jurídica popular na promoção dos direitos fundamentais
Authors: De Freitas Janaina Helena 
Published: March 2019

Resumo: O Brasil é uma país que, por ser periférico, possui muitos problemas que necessitam de ser resolvidos com enfoque jurídico. No presidente artigo, pretende-se realizar uma análise da a questão do acesso à justiça como componente da teoria do padrão do mínimo existencial, seguindo a vertente proposta por Ana Paula de Barcellos. Dentro do acesso à justiça, será analisado o papel das assessorias jurídicas populares como instrumentos de promoção dos direitos fundamentais e do acesso à justiça.
OECD Ülkelerinde Gelir Dağılımının Belirleyenleri
Authors: ACUN Serdar 
Published: March 2019

ABD
emlak piyasasında başlayan daha sonra Avrupa’ya borç krizi olarak sirayet eden
2008 küresel krizi, gelir dağılımına ilişkin tartışmaları yeniden
alevlendirmiştir. En üst %1’lik gelir grubuyla en alt %99’luk gelir grubu
arasındaki artan farklılığın nedenleri ve eşitsizliğin nasıl çözüleceğine
ilişkin konular tartışmaların genellikle merkezinde yer almıştır. Bu çalışmada
amaç OECD ülkelerinde gelir dağılımını etkileyen faktörleri ortaya koymaktır.
İlk başta OECD’de gelir dağılımını analiz eden çalışmalar ele alınmıştır. Daha
sonra ise OECD ülkelerinde gini katsayısı, işgücüne katılım oranı, reel emek
gelirlerindeki değişim, P80/P20 oranı gibi veriler yorumlanmıştır. Verilerin
yorumlanmasından sonra OECD ülkelerinde gelir dağılımının belirleyenleri
üzerine ekonometrik bir analiz uygulanmıştır.
Analiz sonucunda yaş bağımlılık
oranı, ekonomik küreselleşme ve finansallaşma gibi faktörlerin eşitsizliği
artırdığı, emek gelirlerinin milli gelir içindeki payı ve sivil haklardaki
artışın ise adaletli dağılıma olanak sağladığı sonuçlarına ulaşılmıştır.
Beden Eğitimi Öğretmenliği Bölümlerinin Yeterliliği İle İlgili Öğretmen Görüşleri
Authors: UĞRAŞ Sinan , GÜLLÜ Mehmet 
Published: March 2019

Bu araştırmanın amacı beden eğitimi ve spor öğretmenliği bölümlerinin yeterliliği hakkında öğretmen görüşlerini incelemektir. Araştırmada karma yöntemlerden yakınsayan paralel desen kullanılmıştır. Nitel araştırma grubunu, 20 beden eğitimi öğretmeni oluştururken nicel araştırma grubunu 283 beden eğitimi öğretmeni oluşturmaktadır. Veri toplama aracı olarak, “yarı yapılandırılmış görüşme formu” ve “Beden Eğitimi ve Spor Öğretmenliği Bölümlerinin Yeterliliği Ölçeği (BESÖBYÖ)” kullanılmıştır. Araştırma sonucunda beden eğitimi öğretmenleri mezun oldukları lisans programlarının Milli Eğitim Bakanlığına bağlı okulların imkan ve şartlarına uygun nitelikte beden eğitimi öğretmeni yetiştirmediklerini ifade etmişlerdir. Ayrıca lisans derslerini yürüten öğretim elemanlarının yeterli sayıda olmadıkları ve bazı derslerde nitelik bakımından yetersiz kaldıklarını ileri sürmüşlerdir. Beden eğitimi öğretmenleri beden eğitimi ve spor öğretmenliği bölümlerinin tesis ve sosyal imkânlar açısından problemlerin olduğunu belirtmişlerdir.
CLASSE HOSPITALAR NA REGIÃO NORTE DO BRASIL: CONSTRUÇÃO DE DIREITO
Authors: Costa Jaqueline Mendes , Rolim Carmem Lucia Artioli 
Published: March 2019

O estudo tem por objetivo conhecer a estrutura das classes hospitalares da Região Norte do Brasil. A metodologia utilizada incluiu a pesquisa bibliográfica e a documental, focalizando os espaços estruturais de direito da criança e do adolescente hospitalizado. No desdobramento do tema são examinadas regulamentações legais, processos de implantação e estruturação da classe hospitalar enquanto ambiente de desenvolvimento educacional. Os resultados indicam que a estrutura das classes hospitalares apresenta-se de forma díspar na região focalizada, cenário que requer um olhar atento da sociedade, do poder público, e, dos profissionais da educação e da saúde.
ENTRE SEXUALIDADES, MASCULINIDADES E RAÇA: CONTRIBUIÇÕES DO MULTI/ INTERCULTURALISMO PARA A PRÁTICA PEDAGÓGICA
Authors: Silva Junior Paulo Melgaço da , Ivenicki Ana 
Published: March 2019

O presente artigo se propõe a discutir como o multiculturalismo em suas diversas vertentes pode oferecer subsídios para tematizar as questões de sexualidades, raça, masculinidades e classe social de sala de aula. Neste sentido, abordamos os modos com que alunos/as do 6º ano do ensino fundamental vivenciam as questões e como é possível tentar problematizar verdades essencializadas. Para tanto, procurou-se, nas abordagens metodológicas da pesquisa-ação, os elementos necessários para produzir as informações que foram obtidas por meio de encontros semanais da disciplina “Artes Visuais”. Ao analisar os dados, a partir das questões propostas pelo multiculturalismo, estudos de gênero racialidade e sexualidade, observou-se que as expectativas sobre gênero masculinidades são configuradas a partir da visão heteronormativa. Assim os dados do estudo mostram preconceitos trazidos, bem como impactos das ações desenvolvidas, no sentido de uma educação multicultural transformadora.
ANALYSIS OF THE POTENTIAL AND SUITABILITY TOURISM AREAS AS A DIRECTION FOR TOURISM DEVELOPMENT IN WANA WISATA CURUG CIPENDOK BANYUMAS REGENCY 2018
Authors: Parameswari Gati , Muryani Chatarina , Subandriyo Djoko 
Published: March 2019

<p>The research was aimed (1) to know tourism potential in Wana Wisata Curug Cipendok, (2) to know carrying capacity of the protection function in Wana Wisata Curug Cipendok, (3) to know the suitability of tourism areas in Wana Wisata Curug Cipendok, (4) to find out the direction of tourism development in Wana Wisata Curug Cipendok Banyumas Regency 2018”</p><p>This research is a qualitative descriptive study with a field survey method. There are two types of population in this study, namely (1) the respondent population consisting stakeholder, traders, innkeepers and visitors and (2) population of the tourism area, namely Wana Wisata Curug Cipendok. While the research samples also contained two types, namely (1) sample of respondents and (2) sample of suitability of tourism area. Two sampling techniques that used are : (1) purposive sampling aims for stakeholders, traders,and innkeepers and (2) accidental sampling for tourist visitors. The data collection technique using observation, interviews and document analysis.</p><p>The results of this study were (1) Potential in Wana Wisata Curug Cipendok is an enough potential classification (2) Results of carrying capacity of the protection function is in good condition. (3) Results suitability in the area of the waterfall is 67% in class S2 (quite suitable), the results of suitability in the park area amounted to 82.49% in class S1 (highly suitable), and the results of suitability in the area of the lake is at 80% in class S1 (highly suitable). (4) For the direction of development of Wana Wisata Curug Cipendok is to look at weaknesses that become an obstacle and optimize the strength of the research results.</p>
Type-I Tibial Hemimelia
Authors: Yadav Surender Singh 
Published: March 2019

Background:
Tibial hemimelia is a rare but disabling condition. Although reconstructive methods have been described, the recommended treatment typically has been amputation at various levels followed by the use of a suitable prosthesis. A new technique known as femoro-fibulo-calcaneal arthrodesis has been developed as a limb-salvage procedure for patients with type-I deficiency who refuse amputation or have no access to good prosthetic care.

Methods:
Twelve children (18 extremities) with type-I tibial hemimelia were managed surgically. The ages of the patients at the time of surgery ranged from 2 to 14 years. The procedure includes 3 stages: loosening, lengthening, and stabilization. In all patients, the loosening stage involved release of soft-tissue contractures at both ends of the fibula. The lengthening stage involved either supervised lengthening at home with use with use of an external fixator (6 patients) or the use of traction in the hospital (6 patients). In all patients, the stabilization stage was subsequently performed by stabilizing the fibula to the femoral condyles proximally and the talus distally with use of crossed Kirschner wires.

Results:
All 12 patients returned for follow-up for the first 5 years. All patients were evaluated by author. Two patients who had ipsilateral femoral focal deficiency were subsequently lost to follow-up. The remaining 10 patients were followed for a mean of 10 years (range, 5 to 32 years). All 10 patients were able to walk on their feet during follow-up. None of the patients in the present study had an amputation or needed a prosthesis. There were no major complications.

Conclusions:
A new procedure, femoro-fibulo-calcaneal arthrodesis, has been proposed for the treatment of type-I tibial hemimelia. The suggested procedure is simple, biological, cost-effective, and dependable. It provides a long-term stable and functional extremity that enables the patient to walk with plantigrade feet with sensation and proprioception. This limb-saving procedure should be considered as an alternative for patients who refuse to lose the limb or for whom good prosthetic care is unavailable.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Operative Versus Nonoperative Treatment of Pediatric and Adolescent Clavicular Fractures
Authors: Scott Meredith L. , Baldwin Keith D. , Mistovich R. Justin 
Published: March 2019

Background:
The optimal treatment of displaced middle-third clavicular fractures in pediatric and adolescent patients remains controversial. Furthermore, risk factors for the failure of nonoperative treatment have not been clearly defined. Therefore, we designed a systematic review and critical analysis to assess appropriate Grades of Recommendation for evidence-based treatment of middle-third clavicular fractures in the pediatric and adolescent populations.

Methods:
We performed a systematic review following a search of the PubMed, Embase, and Cochrane databases that was conducted in May 2017. The search terms were clavicle, clavic*, and fracture. Our specific PubMed search was (“clavicle”[MeSH] OR clavic*) AND (“fracture”[MeSH] OR fracture*). The results were filtered for English language and subjects ≤18 years of age. There was no chronological limit on the results. The results were then assessed for relevance via a stepwise approach by first screening titles, then abstracts, and, finally, full text. The levels of evidence were determined for studies that met the inclusion criteria. The findings were summarized, and Grades of Recommendation were assigned by consensus.

Results:
Our search returned 3,615 studies. Of these, 215 were potentially relevant. Studies that did not meet our inclusion criteria were removed by consensus. One hundred and nineteen full-text articles were then assessed. Of these, 19 met the inclusion criteria. Overall, patients with both operative and nonoperative treatment of displaced middle-third clavicular fractures have good functional outcomes, with Grade-B supporting evidence. There is Grade-B evidence that operative treatment results in a high complication rate. Both plating and nailing have a high likelihood of requiring implant removal, with Grade-B evidence. There is conflicting evidence regarding the effect of both nonoperative and operative treatment on patient cosmesis following displaced fractures. There is Grade-B evidence that nonunions of pediatric clavicular fractures are exceptionally rare, regardless of treatment strategy. Nonoperatively treated displaced fractures have conflicting evidence regarding any adverse effect displacement may have on functional status.

Conclusions:
Existing literature does not clearly delineate appropriate indications for nonoperative care or relative indications for operative intervention. Further studies are needed to guide treatment and promote better informed consent.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Septic Arthritis of the Native Ankle
Authors: Movassaghi Kamran , Wakefield Connor , Bohl Daniel D. , Lee Simon , Lin Johnny , Holmes George B. , Hamid Kamran S. 
Published: March 2019

» Septic arthritis of the ankle is a serious condition that requires immediate recognition and treatment. Delay may result in permanent destruction of the cartilage and the joint, and the infection may spread to nearby tissues or cause sepsis.»Staphylococcus aureusis the most common causative organism of septic arthritis of the ankle.» Septic arthritis of the ankle typically presents as a tender, warm, and erythematous ankle joint with painful and limited range of motion.» Serum and joint fluid analysis as well as culture and Gram staining should aid in the diagnosis.» Treatment typically includes surgical drainage and antibiotic therapy.
WITHDRAWN: Comparison of 0.05% cyclosporine and 3% diquafosol solution for dry eye patients: A randomized, blinded, multicenter clinical trial
Authors: Park Chang Hyun , Lee Hyung Keun , Kim Mee Kum , Kim Eun Chul , Kim Jae Yong , Kim Tae-im , Kim Hong Kyun , Song Jong Suk , Yoon Kyung-Chul , Lee Do Hyung , Chung Tae-Young , Choi Chul Young , Kim Hyun Seung 
Published: March 2019

Abstract

Background This study is aim to compare the clinical effectiveness between the two most prominent dry eye disease (DED)-specific eye drops, 0.05% cyclosporine (CN) and 3% diquafosol (DQ). Methods This is a multi-centered, randomized, masked, prospective clinical study. A total of 227 eyes from 227 DED patients were randomly allocated to use CN twice per day or DQ six times daily. Cornea and conjunctival staining scores (NEI scale), tear break-up time (TBUT), Schirmer test scores, and ocular surface disease index (OSDI) score were measured at baseline, 4 and 12 weeks after treatment. Results At 12 weeks after treatment, NEI scaled scores were reduced from the baseline by -6.60 for CN and -6.63 for DQ group (P=0.9739 between groups). TBUT and Schirmer values for CN were significantly improved from the baseline at 4 and 12 weeks (P< 0.0001). However, for DQ, TBUT showed significant improvement at week 12 only (P=0.0281). Mean OSDI score differences from the baseline to 12 weeks were -13.03±19.63 in CN and -16.11±20.87 in DQ, respectively (P=0.854 between groups). Regarding drug compliance, the mean instillation frequency of CN was lesser than that of DQ (P<0.001). Conclusions The level of improvement regarding NEI, TBUT, and OSDI scores were not significantly different between the two treatment groups. However, with regards to the early improvement of TBUT and patient compliance, patients using CN improved faster and with greater adherence to drug usage than did those treated with DQ. Trial registration: KCT0002180, Registered 23 December 2016 (retrospectively registered)
Cerebral near-infrared spectroscopy monitoring versus treatment as usual for extremely preterm infants. A protocol for the SafeBoosC phase III randomized clinical trial
Authors: Hansen Mathias , Pellicer Adelina , Gluud Christian , Dempsey Eugene , Mintzer Jonathan , Hyttel-Sørensen Simon , Heuchan Anne Marie , Hagmann Cornelia , Ergenekon Ebru , Dimitriou Gabriel , Pichler Gerhard , Naulaers Gunnar , Cheng Guoqiang , Guimarães Hercilia , Tkaczyk Jakub , Kreutzer Karen B. , Fumagalli Monica , Claris Olivier , Lemmers Petra , Fredly Siv , Szczapa Tomasz , Austin Topun , Jakobsen Janus Christian , Greisen Gorm 
Published: March 2019

Abstract
Background

Cerebral oxygenation monitoring may reduce the risk of death and neurologic complications in extremely preterm infants, but no such effects have yet been demonstrated in preterm infants in sufficiently powered randomised clinical trials. The objective of the SafeBoosC-III trial is to investigate the benefits and harms of treatment based on near-infrared spectroscopy (NIRS) monitoring compared with treatment as usual for extremely preterm infants.

Methods/Design

SafeBoosC III is an investigator-initiated multinational randomized, pragmatic phase III clinical trial. It is open label, but parts will be conducted blinded to intervention. Inclusion criteria consists of infants born below 28 weeks postmenstrual age and parental informed consent (unless the site has is using ‘opt-out’ or deferred consent). Exclusion criteria consists of missing parental informed consent (or if ‘opt-out’ is used, lack of record that clinical staff have explained the trial and the ‘opt-out’ consent process to parents and/or a record in the infant’s clinical file of parents’ decision to opt-out); decision not to provide full life support; and no possibility to initiate cerebral NIRS oximetry within 6 hours after birth. Participants will be randomized 1:1 into either the experimental or control group. Participants in the experimental group will be monitored during the first 72 hours of life with a cerebral NIRS oximeter. Cerebral hypoxia will be treated according to an evidence-based treatment guideline. Participants in the control group will not undergo cerebral oxygenation monitoring and will receive treatment as usual. Each participant will be followed up at 36 weeks postmenstrual age. The primary outcome will be a composite of either death or severe brain injury detected on any of the serial cranial ultrasound scans that are routinely performed in these infants up to 36 weeks postmenstrual age. To detect a 22% relative risk difference between the experimental and control group, we intend to randomize a cohort of 1600 infant.

Discussion

Treatment guided by cerebral NIRS oximetry has the potential to decrease risk of death or survival with severe brain injury in preterm infants. There is an urgent need to assess the clinical effects of NIRS monitoring among preterm neonates.
Aspirin for metal stent in malignant distal common bile duct obstruction (AIMS): Study protocol for a multicenter randomized controlled trial
Authors: Choi Jin Ho , Paik Woo Hyun , You Min Su , Lee Kyong Joo , Choi Young Hoon , Shin Bang-sup , Lee Sang Hyub , Ryu Ji Kon , Kim Yong-Tae 
Published: March 2019

Abstract
Background

Endoscopic retrograde biliary drainage (ERBD) is the treatment of choice for patients with malignant distal common bile duct (CBD) obstruction. Self-expandable metal stents (SEMS), which are commonly used in unresectable cases, have many clinical advantages, including longer stent patency. Although the expected patency of SEMS is around eight months, it has recently been reported that the duration of SEMS patency in patients using aspirin is prolonged. Our study therefore aims to confirm the effect of aspirin on SEMS patency.

Methods

This is an investigator-initiated, prospective, multicenter, double-blind, randomized placebo-controlled trial that will be conducted from November 2017 in four tertiary centers in South Korea. We intend to include in our study 184 adult (≥ 20 years) patients with malignant distal CBD obstruction for whom ERBD with SEMS was successfully performed. The patients will be randomly allocated to two groups, which will comprise patients who have either taken 100 mg aspirin or a placebo for six months after index ERBD. The primary outcome will be the rate of stent dysfunction, and the secondary outcomes will be the duration of patency, the rate of reintervention, and the occurrence of adverse events.

Discussion

The aspirin for metal stents in malignant distal common bile duct obstruction (AIMS) study will determine the efficacy of aspirin in maintaining metal stent patency in patients with malignant distal CBD obstructive.
Clinical-radiological dissociation of a patient with nitrous oxide-induced subacute combined degeneration: a case report
Authors: jiang jiwei , shang xiuli 
Published: March 2019

Abstract
Backgroud

Recently, a number of studies have reported subacute combined degeneration (SCD) induced by nitrous oxide (N2O) abuse. But there is no report about the relationship between the neuroimaging dynamic evolution and clinical manifestations in a patient with N2O-induced SCD.

Cases presentation

Herein we described a 24-year-old male who developed SCD with inverted V-sign on spinal column caused by massive N2O inhalation. The evolution of conventional MRI findings lagged behind clinical manifestations. It seemed to occur a clinical-radiological dissociation.

Conclusions

Both the inability of serum vitamin B12 to reflect cellular vitamin B12 in time and the low-sensitivity of T2-weighted images to reveal cytotoxic edema can account for the clinical-radiological dissociation.