bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selecting the most suitable classification algorithm for supporting assistive technology adoption for people with dementia: A multicriteria framework
Authors: Ortiz‐Barrios Miguel , Nugent Chris , Cleland Ian , Donnelly Mark , Verikas Antanas 
Published: July 2019

AbstractThe number of people with dementia (PwD) is increasing dramatically. PwD exhibit impairments of reasoning, memory, and thought that require some form of self‐management intervention to support the completion of everyday activities while maintaining a level of independence. To address this need, efforts have been directed to the development of assistive technology solutions, which may provide an opportunity to alleviate the burden faced by the PwD and their carers. Nevertheless, uptake of such solutions has been limited. It is therefore necessary to use classifiers to discriminate between adopters and nonadopters of these technologies in order to avoid cost overruns and potential negative effects on quality of life. As multiple classification algorithms have been developed, choosing the most suitable classifier has become a critical step in technology adoption. To select the most appropriate classifier, a set of criteria from various domains need to be taken into account by decision makers. In addition, it is crucial to define the most appropriate multicriteria decision‐making approach for the modelling of technology adoption. Considering the above‐mentioned aspects, this paper presents the integration of a five‐phase methodology based on the Fuzzy Analytic Hierarchy Process and the Technique for Order of Preference by Similarity to Ideal Solution to determine the most suitable classifier for supporting assistive technology adoption studies. Fuzzy Analytic Hierarchy Process is used to determine the relative weights of criteria and subcriteria under uncertainty and Technique for Order of Preference by Similarity to Ideal Solution is applied to rank the classifier alternatives. A case study considering a mobile‐based self‐management and reminding solution for PwD is described to validate the proposed approach. The results revealed that the best classifier was k‐nearest‐neighbour with a closeness coefficient of 0.804, and the most important criterion when selecting classifiers is scalability. The paper also discusses the strengths and weaknesses of each algorithm that should be addressed in future research.
Developing a hazard‐impact model to support impact‐based forecasts and warnings: The Vehicle OverTurning (VOT) Model
Authors: Hemingway Rebecca , Robbins Joanne 
Published: July 2019

AbstractImpact‐based weather warnings have been issued by the Met Office since 2011. The National Severe Weather Warning Service (NSWWS) uses a risk matrix combining the level of impacts the weather may cause and the likelihood of those impacts occurring to define a warning level. The impact assessment can be considered subjective being predominantly based on meteorologist expertise and experience of past high‐impact weather events and discussions with local advisors. The Vehicle OverTurning (VOT) model is a prototype Hazard Impact Model developed to test the hypothesis that risk models can be run in real time for short‐term weather‐related hazards. The method intends to provide an objective, consistent assessment of potential risk to road users in Great Britain during high‐wind events. It aims to support the production of NSWWS wind warnings by highlighting areas of the road network that are at risk of disruption due to vehicles overturning. The VOT model does this by combining probabilistic hazard information with vulnerability and exposure data to produce a risk of vehicle overturning forecast. The model is being demonstrated with operational meteorologists at the Met Office. Initial reviews of the model's output indicate that the scientific approach used in this prototype can identify routes with a higher risk of vehicle overturning, associated with strong wind events. Ad hoc feedback from forecasters support the authors’ belief that the risk modelling approach is useful to operational meteorologists when issuing weather warnings.
Haplotype analysis of SERPINE1 gene: Risk for aneurysmal subarachnoid hemorrhage and clinical outcomes
Authors: Lin Mingkuan , Griessenauer Christoph J. , Starke Robert M. , Tubbs R. Shane , Shoja Mohammadali M. , Foreman Paul M. , Vyas Nilesh A. , Walters Beverly C. , Harrigan Mark R. , Hendrix Philipp , Fisher Winfield S. , Pittet Jean‐Francois , Mathru Mali , Lipsky Robert H. 
Published: July 2019

AbstractBackgroundAneurysmal subarachnoid hemorrhage (aSAH) has high fatality and permanent disability rates due to the severe damage to brain cells and inflammation. The SERPINE1 gene that encodes PAI‐1 for the regulation of tissue plasminogen activator is considered an important therapeutic target for aSAH.MethodsSix SNPs in the SERPINE1 gene (in order of rs2227631, rs1799889, rs6092, rs6090, rs2227684, rs7242) were investigated. Blood samples were genotyped with Taqman genotyping assays and pyrosequencing. The experiment‐wide statistically significant threshold for single marker analysis was set at p < 0.01 after evaluation of independent markers. Haplotype analysis was performed in Haplo.stats package with permutation tests. Bonferroni correction for multiple comparison in dominant, additive, and recessive model was applied.ResultsA total of 146 aSAH patients and 49 control subjects were involved in this study. The rs2227631 G allele is significant (p = 0.01) for aSAH compared to control. In aSAH group, haplotype analysis showed that G5GGGT homozygotes in recessive model were associated with delayed cerebral ischemia (p < 0.01, Odds Ratio = 5.14, 95% CI = 1.45–18.18), clinical vasospasm (p = 0.01, Odds Ratio = 4.58, 95% CI = 1.30–16.13), and longer intensive care unit stay (p = 0.01). By contrast, the G5GGAG carriers were associated with less incidence of cerebral edema (p < 0.01) and higher Glasgow Coma Scale (p < 0.01). The A4GGGT carriers were associated with less incidence of severe hypertension (>140/90) (p < 0.01).ConclusionThe results suggested an important regulatory role of the SERPINE1 gene polymorphism in clinical outcomes of aSAH.
Moisture content effect of banana leaves to radio frequency absorbing
Authors: Colak Bektas 
Published: July 2019

AbstractThe aim of this paper is to express the importance of the moisture content of banana leaves to the evaluation of radio frequency (RF) absorbing performance. Radar absorbing material (RAM) is generally used in electromagnetic compatibility chambers to minimize reflections within the chamber. These materials also reduce the radar traces of air elements by minimizing RF radiation in stealth technology. Chemical substances that are used in fabricating RAM with pyramidal shape are neither cheap nor harmless to the environment. So, vegetable wastes such as bananas, coconut, and rice are studied to use as RAM. In this study, transmission line technique has been used to measure dielectric properties of the sample (banana leaves) in 8.2‐12.4 GHz. It was concluded that dried banana leaves are so sensitive to environmental moisture and the RAM produced from banana leaves gives different return loss values relative to the moisture content of the sample. The water content of the sample is reduced by 5.0% and 4.9%, respectively. In this case, there is nearly 16% and 12% reduction on relatively dielectric constant, about 54% and 33% reduction on dielectric loss, finally approximately 56% and 31% reduction on return loss.
Neuropathy associated with immunoglobulin M monoclonal gammopathy: A combined sonographic and nerve conduction study
Authors: Goedee H. Stephan , Notermans Nicolette C. , Visser Leo H. , van Asseldonk Jan‐Thies H. , Franssen Hessel , Vrancken Alexander F.J.E. , Nikolakopoulos Stavros , van den Berg Leonard H. , van der Pol W. Ludo 
Published: July 2019

AbstractIntroductionWe assessed the specific sonographic pattern of structural nerve abnormalities in immunoglobulin M (IgM) neuropathy and disease controls.MethodsWe enrolled 106 incident patients—32 patients with IgM neuropathy, 42 treatment‐naive patients with chronic inflammatory demyelinating polyneuropathy, and 32 patients with axonal neuropathies. All patients underwent standardized ancillary testing in addition to standardized sonography of the brachial plexus and the large arm and leg nerves bilaterally.ResultsWe found widespread nerve enlargement in IgM neuropathy and chronic inflammatory demyelinating polyneuropathy (CIDP), with specific enlargement of brachial plexus and proximal segments of median nerve but not in axonal disease controls (P < .001). Sonographic nerve hypertrophy in IgM neuropathy was not associated with nerve conduction, clinical, or laboratory characteristics.DiscussionImmunoglobulin M neuropathy is characterized by widespread nerve enlargement indistinguishable from CIDP. Our data provide evidence to confirm that the disease process is not confined to the more distal parts of nerves in either classical demyelinating or axonal variants of neuropathy with associated IgM.
Conformational Analyses of Physiological Binary and Ternary Copper(II) Complexes with l‐Asparagine and l‐Histidine; Study of Tridentate Binding of Copper(II) in Aqueous Solution
Authors: Ramek Michael , Marković Marijana , Mutapčić Ilina , Pejić Jelena , Kelterer Anne‐Marie , Sabolović Jasmina 
Published: July 2019

AbstractThis study explores the structural properties and energy landscapes of the physiologically important bis(l‐asparaginato)copper(II) [Cu(l‐Asn)2] and (l‐histidinato)(l‐asparaginato)copper(II) [Cu(l‐His)(l‐Asn)]. The conformational analyses in the gas phase and implicitly modeled water medium, and magnetic parameters of electron paramagnetic resonance spectra were attained using density functional theory calculations. The apical CuII coordination and hydrogen bonding were analyzed. Predicted lower‐energy structures enabled the confirmation and, for apical bonding, also the refinement of structural proposals from literature. Available experimental results were indecisive regarding the amido‐group binding in the CuII equatorial plane in solutions, but the examination of the relative stability of Cu(l‐Asn)2 conformers in 30 binding modes confirms the glycine‐like mode as the most stable one. Previously reported experimental results for Cu(l‐His)(l‐Asn) were interpreted for l‐His to have a tridentate histamine‐like mode. However, the aqueous conformers with l‐His in the glycinato mode are also predicted to have low energies, which does not contradict the tridentate l‐His binding. The predicted magnetic parameters of conformers with an apical oxygen atom (intramolecular or from a water molecule) can reproduce the experimental data. An extent of conformational flexibility and abundance of l‐His‐containing ternary copper(II) amino acid complexes under physiological conditions may be related.
Higher executive abilities following a blood transfusion in children and young adults with sickle cell disease
Authors: Hood Anna M. , King Allison A. , Fields Melanie E. , Ford Andria L. , Guilliams Kristin P. , Hulbert Monica L. , Lee Jin‐Moo , White Desiree A. 
Published: July 2019

AbstractIndividuals with sickle cell disease (SCD) experience cognitive deficits; however, it remains unclear whether medical treatments for SCD improve cognition. Given that executive abilities are typically impaired in individuals with SCD, they were the focus of the current study. Our primary hypothesis was that executive abilities would be higher acutely soon after a blood transfusion in children and young adults with SCD. We used tests from the NIH Toolbox to assess executive abilities in 27 participants with SCD receiving chronic transfusion in comparison to 34 participants with SCD receiving hydroxyurea (HU) and 41 non‐SCD demographically matched controls, all of whom were tested at two time points. Participants in the transfusion group completed cognitive testing within 3 days after a transfusion (soon after transfusion) and then within 3 days before their next transfusion (long after transfusion) over an interval of 3‐7 weeks. We found that executive abilities were significantly poorer for the transfusion and HU groups than for the control group. In support of our primary hypothesis, executive abilities for the transfusion group were significantly better soon after a transfusion compared to long after a transfusion, χ2(1) = 17.8, P < .0001. Our results demonstrate that executive abilities were higher acutely following a blood transfusion. These findings have implications for daily functioning, medical decision making, and academic achievement in children and young adults with SCD.
The impact of video exposure on students entering school psychology
Authors: Bocanegra Joel O. , Gubi Aaron A. , Callan Gregory L. , Clayson Emery 
Published: July 2019

AbstractSchool psychology is experiencing a shortages crisis. Within this two‐part study, the Social Cognitive Career Theory was used to examine the impact of video interventions on students' choice and application to school psychology programs. A sub‐sample of participants were followed across 4 years. Findings suggest that, when measured immediately before and after, a short video intervention had a significant impact on participants' perceived knowledge and intentions to apply to a school psychology training program. However, when measured across several years, the video was not found to have a significant impact on actual application to a school psychology training program. Nevertheless, exposure to school psychology from multiple sources was still found to be the best predictor of actually applying to a school psychology program. Study results highlight the importance of concerted efforts throughout the career development pipeline to expose students to the profession of school psychology.
Tomato locule number and fruit size controlled by natural alleles of lc and fas
Authors: Chu Yi‐Hsuan , Jang Jyan‐Chyun , Huang Zejun , van der Knaap Esther 
Published: July 2019

AbstractImproving yield by increasing the size of produce is an important selection criterion during the domestication of fruit and vegetable crops. Genes controlling meristem organization and organ formation work in concert to regulate the size of reproductive organs. In tomato, lc and fas control locule number, which often leads to enlarged fruits compared to the wild progenitors. LC is encoded by the tomato ortholog of WUSCHEL (WUS), whereas FAS is encoded by the tomato ortholog of CLAVATA3 (CLV3). The critical role of the WUS‐CLV3 feedback loop in meristem organization has been demonstrated in several plant species. We show that mutant alleles for both loci in tomato led to an expansion of the SlWUS expression domain in young floral buds 2–3 days after initiation. Single and double mutant alleles of lc and fas maintain higher SlWUS expression during the development of the carpel primordia in the floral bud. This augmentation and altered spatial expression of SlWUS provided a mechanistic basis for the formation of multilocular and large fruits. Our results indicated that lc and fas are gain‐of‐function and partially loss‐of‐function alleles, respectively, while both mutations positively affect the size of tomato floral meristems. In addition, expression profiling showed that lc and fas affected the expression of several genes in biological processes including those involved in meristem/flower development, patterning, microtubule binding activity, and sterol biosynthesis. Several differentially expressed genes co‐expressed with SlWUS have been identified, and they are enriched for functions in meristem regulation. Our results provide new insights into the transcriptional regulation of genes that modulate meristem maintenance and floral organ determinacy in tomato.
Group‐based, individualized, comprehensive core stability and balance intervention provides immediate and long‐term improvements in walking in individuals with multiple sclerosis: A randomized controlled trial
Authors: Arntzen Ellen Christin , Straume Bjørn , Odeh Francis , Feys Peter , Normann Britt 
Published: July 2019

AbstractObjectivesWalking impairments are common in individuals with multiple sclerosis. Trunk control is a prerequisite for walking; however, knowledge regarding whether core stability and balance training influence walking is limited. This study aimed to investigate the immediate and long‐term effects of a group‐based, individualized, comprehensive core stability and balance intervention (GroupCoreDIST) compared with those of standard care on walking.MethodsThis assessor‐blinded, prospective randomized controlled trial included 80 participants (Expanded Disability Status Scale scores 1–6.5) randomly allocated to GroupCoreDIST, conducted in groups of three for 60 min three times per week for 6 weeks (18 sessions) or standard care (n = 40/40). One participant attended no posttests, leaving 79 subjects for intention‐to‐treat analysis. The assessments were performed at baseline and at Weeks 7, 18, and 30. Outcomes included the 2‐min walk test (2MWT), 10‐m walk test‐preferred/fast/slow speed (10MWT), Multiple Sclerosis Walking Scale‐12 (MSWS‐12), Patient Global Impression of Change‐walking (PGIC‐walking), Rivermead Visual Gait Assessment (RVGA), and ActiGraphsWgt3X‐BT activity monitors (ActiGraph). The statistical analyses included repeated‐measures mixed models performed in IBM SPSS Version 24.ResultsThere were no significant between‐group differences in the outcome measurements at baseline. The mean differences between groups were significant at all follow‐up time points in favour of GroupCoreDIST for the 2MWT, 16.7 m at 7 weeks (95% CI [8.15, 25.25], 15.08 m at 18 weeks (95% CI [6.39, 23.77]) and 16.38 m at 30 weeks (95% CI [7.65, 25.12]; and the PGIC‐walking, 0.89 points at 7 weeks (95% CI [1.34, 0.45]), 0.97 points at 18 weeks (95% CI [1.42, 0.52]), and 0.93 points at 30 weeks (95% CI [1.39, 0.48]; all p ≤ .001). The 10MWT‐fast speed and the MSWS‐12 showed significant between‐group differences at 7 and 18 weeks and the RVGA at 7 weeks. No between‐group differences were found regarding activity level (ActiGraph) or the 10MWT‐preferred or slow speed.ConclusionCompared with standard care, GroupCoreDIST significantly improved walking immediately after the intervention for up to 24 weeks of follow‐up.
A novel androgen‐reduced prostate‐specific lncRNA, PSLNR, inhibits prostate‐cancer progression in part by regulating the p53‐dependent pathway
Authors: Wang Dan , Wan Xuechao , Zhang Yalong , Kong Zhe , Lu Yali , Sun Xian , Huang Yan , Ji Chaoneng , Li Dujian , Luo Jun , Gu Wei , Wang Chenji , Li Yao , Xu Yaoting 
Published: July 2019

AbstractBackgroundProstate cancer (PCa) is one of the most common cancers in males in China. Long noncoding RNAs (lncRNAs) reportedly play crucial roles in human cancer progression in many studies. However, the molecular mechanisms underlying PCa progression remain unclear.Materials and MethodsWe investigated the lncRNA transcriptome using publicly available RNA‐sequencing data to identify prostate‐specific lncRNAs. Then, the chromatin immunoprecipitation (ChIP) assay identified lncRNA with a direct binding to androgen receptor (AR), hereafter denoted as PSLNR. Quantitative real‐time polymerase chain reaction analysis and Western blot analysis were performed to detect the expression of p53 signaling‐related genes after overexpression PSLNR. The effects of overexpression of PSLNR on cell proliferation, cell cycle, and cell apoptosis were assessed by using CCK‐8 and flow cytometric analysis. We then detected the expression of PSLNR in tissues.ResultWe reported a novel androgen‐reduced prostate‐specific lncRNA, PSLNR, that inhibited PCa progression via the p53‐dependent pathway. By analyzing the NOCODE data set, we reported that PSLNR was specifically expressed in the prostate, suggesting the potential of PSLNR as a biomarker for PCa treatment. The AR pathway was also confirmed to be an upstream regulation signaling pathway of PSLNR by transcriptionally regulating its expression in androgen‐dependent PCa cells. PSLNR also significantly inhibited PCa proliferation by inducing cell apoptosis in a p53‐dependent manner. Thus, PSLNR may be a candidate diagnosis and therapeutic target for PCa.ConclusionsOur study revealed for the first time a novel androgen‐reduced prostate‐specific lncRNA, PSLNR, which inhibited PCa progression via the p53‐dependent pathway, suggesting that PSLNR may be a candidate diagnosis and therapeutic target for PCa.
Fibroblast as a critical stromal cell type determining prognosis in prostate cancer
Authors: Blom Sami , Erickson Andrew , Östman Arne , Rannikko Antti , Mirtti Tuomas , Kallioniemi Olli , Pellinen Teijo 
Published: July 2019

AbstractBackgroundTumor stroma associates with prostate cancer (PCa) progression, but its specific cellular composition and association to patient survival outcome have not been characterized.MethodsWe analyzed stromal composition in human PCa using multiplex immunohistochemistry and quantitative, high‐resolution image analysis in two retrospective, formalin‐fixed paraffin embedded observational clinical cohorts (Cohort I, n = 117; Cohort II, n = 340) using PCa‐specific mortality as outcome measurement.ResultsA high proportion of fibroblasts associated with aggressive disease and castration‐resistant prostate cancer (CRPC). In a multivariate analysis, increase in fibroblast proportion predicted poor cancer‐specific outcome independently in the two clinical cohorts studied.ConclusionsFibroblasts were the most important cell type in determining prognosis in PCa and associated with CRPC. Thus, the stromal composition could be critically important in developing diagnostic and therapeutic approaches to aggressive prostate cancer.
Characterization of bioactive and nutraceutical compounds occurring in olive oil processing wastes
Authors: Ventura Giovanni , Calvano Cosima D. , Abbattista Ramona , Bianco Mariachiara , De Ceglie Cristina , Losito Ilario , Palmisano Francesco , Cataldi Tommaso R.I. 
Published: July 2019

RationaleSeveral bioactive compounds, including phenolic acids and secoiridoids, are transferred from olive drupes to olive oil during the first stage of production. Here, the characterization of these low molecular weight (LMW) compounds in olive oil and in closely related processing materials, like olive leaves (OL) and olive mill wastewaters (OMW), was faced up, for the first time, by matrix‐assisted laser desorption/ionization (MALDI) time‐of‐flight mass spectrometry (TOF MS).MethodsA novel binary matrix composed of 1,8‐bis(tetramethylguanidino)naphthalene (TMGN) and 9‐aminoacridine (9AA) (1:1 molar ratio), displaying excellent ionization properties at low levels of laser energy, was employed in reflectron negative ion mode by a MALDI TOF/TOF system equipped with a neodymium‐doped yttrium lithium fluoride (Nd:YLF) laser (345 nm). MS/MS experiments were performed by using ambient air as the collision gas.ResultsFour major secoiridoids typically present in olive oil, i.e., the aglycones of oleuropein and ligstroside, and oleacein and olecanthal at m/z 377.1, 361.1, 319.1 and 303.1, respectively, were detected in virgin olive oil (VOO) extracts, along with some of their chemical/enzymatic hydrolysis by‐products, such as elenolic (m/z 241.1), decarboxymethyl‐elenolic acids (m/z 183.1) and hydroxytyrosol (m/z 153.1). Besides oleuropein aglycone and oleacein, hydroxylated derivatives of decarboxymethyl‐elenolic acid and hydroxytyrosol were evidenced in OMW.ConclusionsWhile oleuropein was confirmed in OL extracts, several interesting phenolic compounds, including hydroxytyrosol, were recognized in OMW. The proposed approach based on the use of a novel binary matrix for MALDI MS/MS analyses of LMW bioactive compounds can be considered a promising analytical tool for a rapid screening of the phenolic fraction in olive oils and related processing wastes.