bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the ankle position sense in the fatigue foot
Authors: Yoshikawa Masahiro , Nakasa Tomoyuki , Sawa Mikiya , Tsuyuguchi Yusuke , Kanemitsu Munekazu , Ota Yuki , Adachi Nobuo 
Published: September 2018

Category: Ankle Introduction/Purpose: Previous studies have described the damage of sensori-motor control in ankle sprain as being a possible cause of functional instability. The methods to demonstrate the functional instability, have included the postural balance test, peroneal muscle reaction time to sudden ankle inversion, peroneal nerve conduction velocity, and joint position sense of the ankle. On the other hand, isokinetic fatigue of ankle plantar flexion and dorsiflexion exhibits the correlation with postural instability. We hypothesize muscle fatigue around ankle joint causes abnormality of joint position sense, especially inversion at ankle joint, and it will be one of the causes of the ankle sprain. The aim of this study was to evaluate the inversion angle replication errors of before fatigue and after fatigue. Methods: 11 subjects were included in this study. The subjects were placed in a sitting position with the knee flexed at 70°. Each subject placed the foot on a goniometer footplate with the ankle at 20° planter flexion. Subjects were blindfolded to eliminate visual input and to facilitate concentration during testing. The foot was passively rotated internally at random to one of six positions (5°to 30°), always starting from 0°. The footplate was rotated manually to the index angle in approximately 1 s, and held in position for 5 s. Then the ankle was returned to the 0° position. After that, the subjects moved their ankle to match the previous test angle actively. The difference between the index angle and replication angle was measured. Ankles were enforced planter and dorsiflexion according to previous reports, and replication error was measured before and after fatigue. Results: The side-to-side difference of the replication errors was 1.9±1.7° in the before-fatigue group and 2.6±1.8° in the after-fatigue group. There was a statistically significant difference between both the groups (p<0.05). In each inversion angle, there were significant differences of the side-to-side differences of the replication errors at 5°and 10°inversion angles (0.8±0.9°, 1.5±1.4° in the before-fatigue group and 2.2±1.7°, 2.6±1.5° in the after-fatigue group respectively). Conclusion: This study revealed the deficit of joint position sense in ankle inversion induced by fatigue. Fatigue may be one of the risk factor of ankle sprain through the deficit of joint position sense in inversion angle during sports activity.
Effect of subchondral bone sclerosis in repair tissue after bone marrow stimulation for osteochondral talar lesions
Authors: Yoshimura Ichiro , Hagio Tomonobu , Kanazawa Kazuki , Suzuki Masahiro , Yamamoto Takuaki 
Published: September 2018

Category: Arthroscopy Introduction/Purpose: The arthroscopic bone marrow stimulation (ABMS) technique is the first-line procedure for the treatment of osteochondral lesions of the talus (OLT). Recently, T2 mapping was used to evaluate repair cartilage tissue, but the prognostic factors for T2 values after ABMS have never been clarified. Some patients have OLT with sclerotic changes in the subchondral bone, and several articles have suggested that the subchondral bone condition affects the condition of the articular cartilage. Furthermore, subchondral bone sclerosis (SBC) was found to be associated with an inferior outcome after ABMS.The purpose of this study was to investigate the relationship between subchondral bone sclerotic changes and repair tissue T2 values on MRI after ABMS. Methods: Twenty ankles in 20 patients treated with ABMS for OLT were evaluated. The patients included 7 males and 13 females (age, 30.52±21.44 years, lesion length 10.4±3.0mm, lesion area 55.7±26.5mm2). Repair tissue was assessed using a 3T MRI unit, and T2 maps were calculated at the one-year post-ABMS follow up. The patients were divided into two groups; with SBC and without SBC on pre-ABMS CT images. We investigated the relationship between T2 values and SBC. Clinical results were measured using the Japanese Society for Surgery of the Foot (JSSF) Ankle-Hindfoot Scale. Results: No significant mean differences were found in T2 values or JSSF scores between the with SBC and without SBC groups post-ABMS (T2 values; 48.2±3.3ms vs. 50.1±2.9ms, P=0.7 / JSSF scale score; 89.4±5.8 points vs. 93.3±8.2 points, P=0.25). Lesion length was correlated with the T2 values of repair tissue (Length; r=0.3 P=0.01). Age and BMI were not significantly correlated with T2 values of the repair tissue. Conclusion: The presence of SBC prior to ABMS did not affect the T2 values of repair tissue after ABMS. However, we believe that lesion size affected the condition of the repair tissue.
Treatment of late-stage Freiberg disease using a double stemmed flexible silicone prosthesis
Authors: Zhang Ming-Zhu , Yu Guang-rong 
Published: September 2018

Category: Lesser Toes Introduction/Purpose: The purpose of this study was to evaluate the clinical outcomes using a double stemmed flexible silicone prosthesis for the treatment of Freiberg disease in its late stages. Methods: The subjects consisted of 13 feet from 13 cases suffering from Freiberg disease in their late stages. They underwent double stemmed flexible silicone prosthesis replacement for metatarsophalangeal joints. The average age was 63.8 (range 30~88) years. The average follow up period was 26 (range 18–42) months. The investigation was carried out using the range of motion (ROM), visual analog scale (VAS), AOFAS and Maryland metatarsophalangeal joints scale before surgery and at the latest follow-up. Results: The average ROM of dorsal flexion improved from 39.3±6.1° before surgery to 75.4±8.6° at latest follow-up (p<0.001). The average ROM of plantar flexion improved from 19.0±11.4° before surgery to 20.2±9.3° at latest follow-up (p=0.14). The average VAS significantly improved from 8.1±0.5 before surgery to 2.6±0.2 at latest follow-up (p<0.001). The average Maryland metatarsophalangeal joints score significantly improved from 65.3±9.3 points before surgery to 90.3±4.1 points at the latest follow-up (p<0.001). The average AOFAS was 89.4±8.5 after surgery compared 56.3±6.4 preoperatively (p<0.005). Conclusion: A flexible silicone prosthesis replacement was carried out to treat Freiberg disease in its late stages. The function was observed in all cases with improved clinical results. The silicone prosthesis was considered to be useful in certain cases.
Acute Retinal Necrosis Multicenter Case Series: Prognostic Indicators and Treatment Outcomes
Authors: Dorman Andrew , Donaldson Mark 
Published: September 2018

Purpose: The purpose of this article is to report the prognostic associations of acute retinal necrosis (ARN), determine the diagnostic utility of aqueous vs vitreous polymerase chain reaction (PCR), and describe outcomes of antiviral, corticosteroid, antithrombotic, and laser retinopexy treatment. Methods: A retrospective, nonrandomized case series was conducted. Primary outcomes included final visual acuity (VA), severe VA loss (≥1.00 log of the minimum angle of resolution [logMAR] [Snellen equivalent, <20/200]), and retinal detachment (RD). Results: Fifty eyes of 46 patients were diagnosed with ARN. Varicella-zoster and herpes simplex viruses were the viral etiology in 29 and 16 eyes, respectively. Five were diagnosed on clinical criteria. Intravenous acyclovir was administered in 90% of eyes. Neither induction therapy for ≥13 days ( P = .692) nor intravitreal medication ( P = .203) decreased the incidence of severe vision loss. Maintenance antiviral medication was administered in 96% of eyes (50% received >13 weeks). At final follow-up, 40% of eyes had severe vision loss (range, –0.08 to +3.0 logMAR [Snellen, 20/17-no perception of light]). Forty-six percent developed RD. Relative afferent pupillary defect (RAPD), zone and extent of retinitis, and RD were prognostic of final VA. Antithrombotic therapy was administered in 25/50 eyes and was associated with lower incidence of severe VA loss ( P = .027) and better final VA ( P = .040). Laser retinopexy was performed in 40% of eyes with no significant effect on RD incidence ( P = .901) or severe VA loss ( P = .451). Conclusions: ARN has a high incidence of RD and poor visual outcomes. Aqueous humor PCR is the first-line diagnostic investigation. Prognostic indicators include RD, RAPD, zone, and extent of retinitis. Induction antiviral medication is appropriate for at least 12 days. Antithrombotic medication is associated with improved outcomes. Laser retinopexy does not reduce the incidence of RD.
Engineered FVIII-expressing cytotoxic T cells target and kill FVIII-specific B cells in vitro and in vivo
Authors: Parvathaneni Kalpana , Scott David W. 
Published: September 2018

AbstractHemophilia A is an X-linked bleeding disorder caused by mutations in the factor VIII (FVIII) gene (F8). Treatment with recombinant or plasma-derived FVIII replacement therapy is standard therapy. A major problem in treating hemophilia A patients with therapeutic FVIII is that 20% to 30% of these patients produce neutralizing anti-FVIII antibodies (inhibitors) because they are not immunologically tolerant to this human protein. Hence, there is a need to establish tolerogenic protocols to FVIII epitopes. To specifically target FVIII-specific B cells, we engineered immunodominant FVIII domains (A2 and C2) as a chimeric antigen receptor expressed by both human and murine cytotoxic T cells. This FVIII domain engineered B-cell antibody receptor (BAR) that expresses T cells was capable of killing FVIII-reactive B-cell hybridomas in vitro and in vivo. Moreover, FVIII BAR CD8 T cells blocked the development of specific antibody from unimmunized spleen cells stimulated polyclonally with lipopolysaccharide in vitro. In addition, adoptive transfer of FVIII A2- and C2-BAR CD8 T cells significantly reduced the anti-FVIII antibody formation in hemophilic mice. These data suggest that BAR-engineered T cells are a promising approach for future prophylactic treatment for patients with severe hemophilia A who are at high risk of developing inhibitors.
Physiological electric field works via the VEGF receptor to stimulate neovessel formation of vascular endothelial cells in a 3D environment
Authors: Chen Yihong , Ye Liyan , Guan Linbo , Fan Ping , Liu Rui , Liu Hao , Chen Jinxin , Zhu Yue , Wei Xing , Liu Yu , Bai Huai 
Published: September 2018

ABSTRACTElectrical stimulation induces significant neovessel formation in vivo. We have shown that electrical stimulation of endothelial cells functions as an important contributor to angiogenesis in monolayer culture. Because angiogenesis occurs in a three-dimensional (3D) environment, in this study we investigated the effects of a direct current (DC) electrical field (EF) on endothelial neovessel formation in 3D culture. There was a significant increase in tube formation when endothelial cells were stimulated with EF for 4 h. The lengths of the tube-like structures were augmented further by the continued EF exposure. The lengths of the tubes also increased dose-dependently in the EF-treated cultures in the field strengths of 50 mV/mm∼200 mV/mm for 6 h. Electrical fields of small physiological magnitude enhanced VEGF expression by endothelial cells in 3D culture. EF treatment also resulted in activation of VEGFR2, Akt, extracellular regulated kinase 1,2 (Erk1/2), as well as the c-Jun NH2-terminal kinase (JNK). The tyrosine kinase inhibitor SU1498 that blocks VEGFR2 activity exhibited a potent inhibition of tube growth, and the Akt inhibitor MK-2206 2HCl, the Erk1/2 inhibitor U0126 and the JNK inhibitor SB203580 significantly reduced EF-stimulated tubulogenesis. These results suggest the importance of the VEGFR2 signaling pathway during EF-induced angiogenesis. The results of this study provide novel evidence that endogenous EFs may promote blood vessel formation of endothelial cells by activating the VEGF receptor signaling pathway.
A PRÁTICA DA LIBERDADE NO ESTADO MODERNO NAS CONCEPÇÕES DE JOHN LOCKE E JEAN-JACQUES ROUSSEAU
Authors: Pinheiro Veralucia , Bezerra Nilson Pereira 
Published: September 2018

Este artigo apresenta considerações sobre concepções de Estado, a partir do pensamento de dois pensadores clássicos, cujas formulações sobre o conceito de liberdade apresentam contribuições significativas para a compreensão dos princípios que regem o Estado Moderno. A primeira fundamenta-se na caracterização do liberalismo encontrado em Locke (1983), cuja concepção de liberdade está diretamente ligada ao direito à propriedade, tendo por base o poder econômico dos indivíduos. A segunda está ancorada no conceito de liberdade de Rousseau (1978: sd), que atribui o exercício da liberdade ao pleno direito individual de participação política e de igualdade jurídica sem distinção. O objetivo dessa análise é sistematizar as formulações teóricas destes pensadores acerca do processo de construção do Estado na modernidade, mediante a identificação e a problematização de argumentos que posteriormente serão utilizados para legitimar as ideologias que visam garantir sustentação à sociedade capitalista. Subjaz ainda a esse objetivo a intenção de refletir sobre o contexto em que se desenvolve a formação do sujeito na sociedade moderna, apto a reproduzir os valores e as concepções definidos pelas classes dominantes, limitando desse modo sua formação a sua inserção no mercado de trabalho.
Towards a sustainable Open Access monograph publishing workflow for academic institutions
Authors: Schrader Antonia , Grossmann Alexander , Reiche Michael 
Published: September 2018

Across the world, there is a growing interest in Open Access (OA) publishing. Therefore, OA publishing has become a trend and is of key importance to the scientific community. However, observing the publication landscape in Germany leads to a striking finding of very different approaches. In particular, OA book publishing is still in relatively early stages, leading to OA books being much less frequently published than OA journal articles. However, although well-established publishers offer the publication of OA books, only certain researchers can actually publish, because of high Book Processing Charges (BPCs). In contrast to such publishers, university presses publish books as OA without any or at significantly lower charges; however, university presses are often inadequately staffed and do not have the technical know-how of the state-of-the-art publishing of OA books possessed by well-established publishers.
For these reasons, our research project aims to develop an ideal and transferable publication workflow for OA books that is both cost-effective and personnel-efficient as well as media-neutral to enable universities to publish their publications as OA. To this end, a one-day meeting with stakeholders of the publication landscape was held in June 2018 at the University of Applied Science in Leipzig, Germany. During the meeting, the stakeholders were asked to present their views on the current situation and also the lessons learned and the shortcomings of the existing approaches.
As a result, the observation was confirmed that the publication landscape is very heterogeneous and that there are no standardised interfaces and no harmonised practices for publishing OA books. Furthermore, in a discussion with the stakeholders during the second part of the meeting, further various issues of OA book publishing were revealed that have to be considered. Additionally, the various challenges and wishes of the stakeholders could be classified into five topic areas.
These findings illustrate that the primary task of the research project has to be the analysis of the existing publishing workflows and abstracting generally valid processes that are needed to publish OA books. Additionally, the further issues of OA book publishing, mentioned by the stakeholders, have to be addressed during the development. The five topic areas will help reduce the complexity of this project.
Chemical analysis and antioxidant activities of bark extracts from four endemic species of Hyrcanian forests in Iran
Authors: Lakani Sahba Aliniyay , Hedjazi Sahab , Abdulkhani Ali 
Published: September 2018

Abstract
Chemical analysis of the bark from four Hyrcanian forest species, Pterocarya fraxinifolia, Alnus subcordata, Gleditsia caspica and Parrotia persica were performed, and their total phenol contents, and antioxidant and chelating activities were evaluated. The greatest total phenol content (TPhC), 54.3% in dry extract, was detected in P. fraxinifolia bark and the lowest one in G. caspica bark with 4.5%. The 50% inhibitory concentrations (IC50) in the radical-scavenging assay against DPPH radicals in bark acetone extracts of P. fraxinifolia, A. subcordata, G. caspica and P. persica were 0.17, 0.21, 13.35, 0.19 mg ml−1, respectively. In the metal-chelating activity system, G. caspica extract demonstrated significant activity. Pterocarya fraxinifolia, A. subcordata and P. persica bark acetone extracts revealed a high potential for inhibition of DPPH radicals due to high amounts of phenolics. Superior health benefits can be expected from the compounds syringol, 4-vinylguaiacol, tyrosol, chavicol, resorcinol, hydroquinone, vanillin, rheosmin and acetophenone. Gleditsia caspica was found to have significant chelating activity due to isoeugenol.
Focused-ion-beam-based nano-kirigami: from art to photonics
Authors: Li Jiafang , Liu Zhiguang 
Published: September 2018

Abstract
Kirigami, i.e. the cutting and folding of flat objects to create versatile shapes, is one of the most traditional Chinese arts that has been widely used in window decorations, gift cards, festivals, and various ceremonies, and has recently found intriguing applications in modern sciences and technologies. In this article, we review the newly developed focused-ion-beam-based nanoscale kirigami, named nano-kirigami, as a powerful three-dimensional (3D) nanofabrication technique. By utilizing the topography-guided stress equilibrium induced by ion-beam irradiation on a free-standing gold nanofilm, versatile 3D shape transformations such as upward buckling, downward bending, complex rotation, and twisting of nanostructures are precisely achieved. It is shown that the generated 3D nanostructures possess exceptional geometries and promising photonic functionalities, including strongly interacting multiple Fano resonances, giant optical chirality, clear photonic spin Hall effects, and diffractive phase/polarization effects. The studies of such structures can build up novel platforms for versatile manufacturing techniques and be helpful to establish new areas in plasmonics, nanophotonics, optomechanics, MEMS/NEMS, etc., with the generation of exotic but functional nanostructures.
Two Lovers and a Lion: Pankrates’ Poem on Hadrian’s Royal Hunt
Authors: Höschele Regina 
Published: September 2018

AbstractThis article offers a new reading of Pankrates’ poem on Hadrian’s and Antinoos’ hunt of a lion in 130 AD, examining both its intertextual dialogue with Homer and its evocation of Egyptian imagery. I first show how the raging lion, which emerges directly out of a Homeric simile (Il.20.163–164), has been transformed fromcomparatumtocomparandum: he no longer serves to illustrate a warrior’s force, but has himself become part of the main narrative and the subject of analogy. Contemplating theaitionin which the text culminated I argue that the Antinoeian lotus, which grew out of the lion’s blood, ought to be read against the backdrop of Egyptian mythology and iconography as an emblem of rebirth. Both Pankrates’ allusions to Homer, which subtly evoke Achilles’ loss of Patroklos, and the symbolic function of the lotus strongly suggest that the poem was composed in the aftermath of Antinoos’ death and conceived as a celebration of the youth’s apotheosis.
Consumer Privacy and the Incentives to Price-Discriminate in Online Markets
Authors: de Cornière Alexandre , Montes Rodrigo 
Published: September 2018

Abstract
This paper studies how product customization and consumer privacy affect a monopolist’s incentives to engage in perfect price discrimination. We consider a monopolist that faces an ex ante choice to commit to price discrimination or to a uniform price. We introduce a simple model in which a monopolist can use analytics to access consumer data to both price-discriminate and offer customized products. In turn, consumers can protect their privacy to avoid price discrimination at a cost. By committing not to price-discriminate, the firm induces consumers to not protect their data, which allows it to customize the product. It can then extract the extra value through an increased uniform price. This strategy is profitable when the value added through customization is sufficiently high. An intermediate quality of analytics gives the monopolist more incentives to set a uniform price.
A Subpopulation of Foxj1-Expressing, Nonmyelinating Schwann Cells of the Peripheral Nervous System Contribute to Schwann Cell Remyelination in the Central Nervous System
Authors: Ma Dan , Wang Bowei , Zawadzka Malgorzata , Gonzalez Ginez , Wu Zhaozong , Yu Bin , Rawlins Emma L. , Franklin Robin J.M. , Zhao Chao 
Published: September 2018

New myelin sheaths can be restored to demyelinated axons in a spontaneous regenerative process called remyelination. In general, new myelin sheaths are made by oligodendrocytes newly generated from a widespread population of adult CNS progenitors called oligodendrocyte progenitor cells (OPCs). New myelin in CNS remyelination in both experimental models and clinical diseases can also be generated by Schwann cells (SCs), the myelin-forming cells of the PNS. Fate-mapping studies have shown that SCs contributing to remyelination in the CNS are often derived from OPCs and appear not to be derived from myelinating SCs from the PNS. In this study, we address whether CNS remyelinating SCs can also be generated from PNS-derived cells other than myelinating SCs. Using a genetic fate-mapping approach, we have found that a subpopulation of nonmyelinating SCs identified by the expression of the transcription factor Foxj1 also contribute to CNS SC remyelination, as well as to remyelination in the PNS. We also find that the ependymal cells lining the central canal of the spinal cord, which also express Foxj1, do not generate cells that contribute to CNS remyelination. These findings therefore identify a previously unrecognized population of PNS glia that can participate in the regeneration of new myelin sheaths following CNS demyelination.SIGNIFICANCE STATEMENTRemyelination failure in chronic demyelinating diseases such as multiple sclerosis drives the current quest for developing means by which remyelination in CNS can be enhanced therapeutically. Critical to this endeavor is the need to understand the mechanisms of remyelination, including the nature and identity of the cells capable of generating new myelin sheath-forming cells. Here, we report a previously unrecognized subpopulation of nonmyelinating Schwann cells (SCs) in the PNS, identified by the expression of the transcription factor Foxj1, which can give rise to SCs that are capable of remyelinating both PNS and CNS axons. These cells therefore represent a new cellular target for myelin regenerative strategies for the treatment of CNS disorders characterized by persistent demyelination.