bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green Transition and Industrial Relations at the Workplace: Evidence From Italian Firms
Authors: Damiani M. , Pompei Fabrizio , Ricci Andrea 
Published: November 2024

ABSTRACTThis article analyses the role of green investments (GIs) in the adoption of decentralised bargaining and the single aspects negotiated therein. Using data on a large representative sample of Italian firms, we find that investing in green technologies increases the overall probability of decentralised agreements. Further, GIs lead to an increase in negotiations on performance‐related pay and welfare benefits. These results are robust to an econometric strategy that controls for unobserved heterogeneity and endogeneity issues. Our explanation for this evidence is that the current ecological transition in production processes is likely causing significant organisational changes. Managing these changes requires increased flexibility in negotiating critical issues at the company level, such as wage premiums and non‐monetary benefits to employees.
The endocannabinoid anandamide mediates anti‐inflammatory effects through activation of NR4A nuclear receptors
Authors: Teichmann Tom , Pflüger‐Müller Beatrice , Giménez Virna Margarita Martín , Sailer Fiona , Dirks Henrik , Zehr Simonida , Warwick Timothy , Brettner Felix , Munoz‐Tello Paola , Zimmer Andreas , Tegeder Irmgard , Thomas Dominique , Gurke Robert , Günther Stefan , Heering Jan , Proschak Ewgenij , Geisslinger Gerd , Bibli Iris‐S. , Heringdorf Dagmar Meyer zu , Manucha Walter , Windbergs Maike , Knapp Stefan , Weigert Andreas , Leisegang Matthias S. , Kojetin Douglas , Brandes Ralf P. 
Published: November 2024

Background and purposeEndocannabinoids are lipid mediators, which elicit complex biological effects that extend beyond the central nervous system. Tissue concentrations of endocannabinoids increase in atherosclerosis, and for the endocannabinoid N‐arachidonoyl‐ethanolamine (anandamide, AEA), this has been linked to an anti‐inflammatory function. In this study, we set out to determine the anti‐inflammatory mechanism of action of AEA, specifically focusing on vascular smooth muscle cells.Experimental approachRNA‐sequencing, RT‐qPCR, LC‐MS/MS, NanoBit, ChIP, microscale thermophoresis, NMR structural footprinting, Gal4 reporter gene assays and loss of function approaches in cell and ex vivo organ culture were used.Key resultsAEA pretreatment attenuated the cytokine‐mediated induction of inflammatory gene expression such as CCL2. This effect was also observed in preparations obtained from cannabinoid receptor knockout mice and after pertussis toxin treatment. The anti‐inflammatory effect of AEA required preincubation, suggesting an effect through gene induction. AEA increased the expression of the nuclear receptors NR4A1 and NR4A2. Knockdown and knockout of these receptors blocked the AEA‐mediated anti‐inflammatory effect in cell culture and aortic organ culture, respectively. Conversely, NR4A agonists (CsnB, C‐DIM12) attenuated inflammatory gene expression. AEA binds to NR4A, and mutations in NR4A attenuated this effect. The interaction of AEA with NR4A caused recruitment of the nuclear corepressor NCoR1 to the CCL2 promoter, resulting in gene suppression.Conclusion and implicationsBy binding to NR4A, AEA elicits an anti‐inflammatory response in vascular smooth muscle cells. NR4A‐binding by AEA analogues may represent novel anti‐inflammatory agents.
Effects of Minocycline on Early Wound Healing after Implant Placement: An In Vitro and Randomized Clinical Study
Authors: Zhang Yanjun , Duan Xiaobo , Xue Fei , Zhou Xinyi , Yuan Quan , Yang Xingmei 
Published: November 2024

ABSTRACTObjectiveTo determine the in vitro effects of minocycline on human gingival fibroblasts (HGFs), its clinical impact on early wound healing after implant placement, and its potential mechanism of action.MethodsFirst, we evaluated the in vitro proliferation, migration, and collagen production of HGFs treated with different concentrations of minocycline, as well as the underlying mechanism. Subsequently, we conducted a clinical trial and randomly assigned 40 partially edentulous patients to either the test (minocycline hydrochloride treatment) or control (blank control) group immediately after implant surgery. The early wound healing score (EHS), pain index, gingival index (GI), modified sulcus bleeding index (mSBI), and peri‐implant crevicular fluid samples were assessed or collected 3 and/or 7 days after surgery.ResultsIn vitro, 1 μg/mL minocycline promoted the proliferation, migration, and collagen production of HGFs. Minocycline inhibited collagen degradation by downregulating the expression of matrix metalloproteinase‐2 (MMP‐2) and MMP‐14 and upregulating tissue inhibitors of metalloproteinases‐2. However, higher concentrations of minocycline, 10 and 100 μg/mL, exhibited adverse effects. In the randomised clinical trial, the test group showed significantly better clinical outcomes compared to the control group, with higher EHS and lower GI, mSBI, concentrations of IL‐1β, IL‐10, and TNF‐α, and relative abundance of Streptococcus and gram‐negative anaerobic bacteria.ConclusionsSmall doses of minocycline (1 μg/mL) promoted the proliferation and migration of HGFs and inhibited collagen degradation in vitro. Locally delivered minocycline after implant surgery improves clinical outcomes by promoting early wound healing, relieving the inflammatory response, and decreasing early colonisation of gram‐negative anaerobic bacteria.Trial RegistrationThis clinical trial was registered in the Chinese Clinical Trial Registry (registration number: ChiCTR2100044680)
Selective Inhibition of P2Y1 and P2Y12 Receptor Signal Pathways in Platelet Aggregation in Transgenic Cell Lines and Rats by Potassium 2‐(1‐Hydroxypentyl)‐Benzoate, Puerarin and Salvianolic Acid B
Authors: Li Yiying , Wang Weiping , Cai Jie , Feng Nan , Xu Shaofeng , Wang Ling , Wang Xiaoliang 
Published: November 2024

ABSTRACTAimPotassium 2‐(1‐hydroxypentyl)‐benzoate (dl‐PHPB), puerarin and salvianolic acid B are three natural products or derivatives that can inhibit platelet aggregation. However, the mechanisms of dl‐PHPB, puerarin and salvianolic acid B to inhibit platelet aggregation are still not clear.MethodHere, 2‐methylthioadenosine diphosphate (2‐MeSADP) was used as an inducer to confirm the effects of three drugs on platelet aggregation and illustrate the corresponding mechanisms.ResultThe results indicated that dl‐PHPB, puerarin and salvianolic acid B significantly inhibited platelet aggregation both in vivo and in vitro. In addition, the content of IP3, cAMP and intracellular [Ca2+]i were measured in HEK293 cell lines overexpressing P2Y1 and P2Y12. Dl‐PHPB and puerarin could obviously reduce 2‐MeSADP‐induced IP3 increase, but salvianolic acid B showed no effects. Unlike dl‐PHPB and puerarin, which had no effects on 2‐MeSADP‐induced cAMP decrease, salvianolic acid B significantly reversed the reduction of cAMP. Both dl‐PHPB and puerarin could decrease the enhanced intracellular [Ca2+]i induced by 2‐MeSADP; however, salvianolic acid B showed no effect on intracellular [Ca2+]i elevation.ConclusionThese results suggested that dl‐PHPB and puerarin inhibited platelet aggregation via targeting at P2Y1 receptor and P2Y1‐Gq‐IP3‐Ca2+ signal pathway. Differently, salvianolic acid B inhibited platelet aggregation via targeting at P2Y12 receptor and via Gi‐AC‐cAMP signal pathway.
Neighborhood Awareness and Stock Return Synchronicity: Evidence from Satellite Nighttime Light Data
Authors: Meng Chen , Shu Haibing 
Published: November 2024

AbstractThis paper examines the impact on stock return synchronicity of information provided by people who neighbor firms. Neighboring people have inherent advantages in acquiring and interpreting information. We employed novel satellite nighttime light data as a proxy for information held by neighboring people. Our analyses confirmed that brighter nighttime light was related to greater and better‐quality information production. Using a sample of 18,963 firm–year observations over the 2000–2013 period, we found that information from nearby people facilitated the incorporation of firm‐specific information into stock prices, resulting in lower stock return synchronicity. The results were robust when using the slope as an instrumental variable and were supported by various sensitivity checks. The effect of nighttime light intensity was more pronounced for firms operating across multiple geographic regions or diverse industries, those situated near more parks and shopping malls, and those with fewer institutional investors and less media coverage.
Relationship between trajectory of Chinese visceral adiposity index and risk of type 2 diabetes mellitus: Evidence from the China‐PAR project
Authors: Fu Xueru , Zhao Yang , Wu Yuying , Wen Liuding , Huo Weifeng , Zhang Dongdong , Zhang Yanyan , Li Jianxin , Lu Xiangfeng , Hu Fulan , Zhang Ming , Hu Dongsheng 
Published: November 2024

AbstractAimsThis study aimed to identify the distinct change trajectories of the Chinese visceral adiposity index (CVAI) over time and to investigate their associations with risk of type 2 diabetes mellitus (T2DM).Materials and MethodsThis study included 52 394 participants from the prospective project, the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China‐PAR). The CVAI was calculated using measures of age, body mass index, waist circumference, triglycerides and high‐density lipoprotein cholesterol. Latent mixture modelling was conducted to fit distinct trajectory patterns. The logistic regression model was applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of T2DM with various CVAI trajectory patterns.ResultsFour distinct CVAI trajectory patterns were identified: low‐increasing, moderate‐increasing, moderate high‐increasing and high‐increasing. Compared with low‐increasing CVAI, participants with moderate‐increasing (OR 1.73, 95% CI 1.49–2.00), moderate high‐increasing (3.48, 3.01–4.03) and high‐increasing CVAI (5.50, 4.67–6.47) had a significantly increased risk of T2DM. Similar trajectory patterns were identified in both men and women. The ORs (95% CI) for moderate‐increasing, moderate high‐increasing and high‐increasing groups were 3.28 (2.56–4.19), 7.85 (6.09–10.13) and 13.21 (9.98–17.49) in women respectively, and 1.20 (0.99–1.45), 2.18 (1.82–2.62) and 3.60 (2.93–4.43) in men respectively, when compared to the low‐increasing CVAI group. Further, significant effect modifications for age, smoking and physical activity (all Pinteraction <0.05) were observed in the relationship between CVAI trajectory patterns and T2DM.ConclusionsInitially high and persistently elevated CVAI is significantly associated with an increased risk of T2DM, with a particular focus on women, younger people, nonsmokers and physically inactive individuals. Continuous monitoring of CVAI levels will benefit effective identification, early intervention and management of individuals at high risk of T2DM.
A Cross‐Sectional Survey of Anesthesiologists' Awareness Toward Traumatic Dental Injuries During General Anesthesia in Syrian Arab Republic
Authors: Al‐Shiekh Mohammed N. , Altinawi Mohamed K. , Darwish Bana , Alzoubi Hasan 
Published: November 2024

ABSTRACTBackgroundTraumatic dental injuries with tracheal intubation during general anesthesia are considered one of the most common complications. It is also the primary reason for malpractice legal claims against anesthesiologists according to insurance companies. There is much information regarding the incidence, consequences, and risk factors of traumatic dental injuries during general anesthesia. This study aimed to assess the awareness (knowledge, practice, and attitude) of anesthetists regarding peri‐anesthetic traumatic dental injuries and discuss measures to reduce the risk regarding peri‐anesthetic traumatic dental injuries.Materials and MethodsSixty seven anesthetists participated in this cross‐sectional survey between January 2023 and July 2023, which was carried out in the Syrian Arab Republic. The questionnaire was generated using Google Forms and sent individually, as the researcher (MNA) was accompanied by all included anesthesiologists while filling out all the questionnaire paragraphs to answer any questions. The Fisher exact test and Pearson's Chi‐squared test were used to analyze the results.ResultsThe dental trauma caused by the anesthetists during their professional careers was 38.8%, and none of them were exposed to any legal claim. 77.6% of the anesthetists thought that avulsed permanent teeth could be replanted, 46.2% believed that the procedure must be done in < 30 min, and 84.6% thought they could not do it themselves and would send the patient to a dentist after the procedure. More than half of respondents (63.5%) indicated that the sterile saline solution was the best storage medium for avulsed teeth. Furthermore, 74.6% of anesthetists stated that emergency intubations are related to more traumatic dental injuries in comparison with elective intubation and about 62% were aware of the importance of mouthguard. However, nearly 57% complained about the shortage of knowledge related to the oral cavity and its special structure.ConclusionsSyrian anesthetists have limited awareness (knowledge, practice, and attitude) of traumatic dental injury classification, prevention, and management. More information and training are still needed about factors used within clinical dentistry.
Simplified Composite Restorations for Fractured Young Incisors: A Clinical Review
Authors: Çehreli Zafer C. 
Published: November 2024

ABSTRACTTooth fractures are a common consequence of dental trauma in young patients, requiring prompt and effective restorative interventions that ensure both functional integrity and esthetic appeal. Although resin stratification (layering) is the gold standard for achieving life‐like restoration of fractured teeth, many clinicians find it technically challenging due to the time and effort required for precise shade matching, concealing the fracture line, and accurate placement of resin composite layers with different levels of opacity. The more recent generation of monoshade composites, with their ability to adapt to various tooth shades, reduce the complexity of multi‐layer restorations, and improve chairside efficiency. Additionally, the composite cutback technique has gained attention as an effective method for restoring fractured teeth in young patients. This method combines the benefits of monoshade composites and the precision of simple additional layering to enhance both the esthetic and functional outcomes of the restorations. This mini‐review provides a comprehensive analysis of the composite cutback technique, the role of monoshade composites, and their clinical application in the restoration of fractured young teeth.
Future‐Proofing Dentistry: A Qualitative Exploration of COVID‐19 Responses in UK Dental Schools
Authors: Vernon Jon J. , Vinall‐Collier Karen , Csikar Julia , Emms George , Lancaster Paula E. , Nattress Brian R. , Wood David J. 
Published: November 2024

ABSTRACTIntroductionThe COVID‐19 pandemic had extensive influence on dental education. UK dental schools were compelled to respond with substantial adaptations to clinical training approaches and environments to mitigate educational impact.Materials and MethodsThe Surveying Pandemic Education Response in Higher Education Dental Schools (SPEARHEAD) study aimed to retrospectively evaluate the diverse responses of UK dental schools to the COVID‐19 pandemic. All UK dental schools were invited to participate in semi‐structured interviews to ascertain institutional responses, with transcripts subjected to thematic framework analysis.Results and DiscussionTen UK dental schools contributed to the study and three main themes were identified: student education, environment, and procedures and equipment. The most common approach to student education was the reduction of student numbers in clinical areas; however, this increased supervisory demands. While there was widespread acknowledgement of the need for enhanced ventilation, implementing the necessary modifications was frequently constrained by building configurations and financial implications. Numerous procedural adjustments were implemented, accompanied by widespread adoption of enhanced personal protective equipment. Fallow periods were common, although differing durations underscored the need for data‐driven guidance. Many schools transitioned towards electric speed‐controlled handpieces, but the need to reflect real‐world scenarios often led to a reversion to air turbines.ConclusionUK dental schools showed initiative, resilience, and ingenuity in safeguarding students from enduring irretrievable educational setbacks amidst the challenges posed by the COVID‐19 pandemic. Validating a data‐driven strategy for addressing future threats would facilitate a unified response, minimising the educational repercussions and bolstering the resilience of dental training.
Performance of a Generative Pre‐Trained Transformer in Generating Scientific Abstracts in Dentistry: A Comparative Observational Study
Authors: Alencar‐Palha Caio , Ocampo Thais , Silva Thaisa Pinheiro , Neves Frederico Sampaio , Oliveira Matheus L. 
Published: November 2024

ABSTRACTObjectivesTo evaluate the performance of a Generative Pre‐trained Transformer (GPT) in generating scientific abstracts in dentistry.MethodsTen scientific articles in dental radiology had their original abstracts collected, while another 10 articles had their methodology and results added to a ChatGPT prompt to generate an abstract. All abstracts were randomised and compiled into a single file for subsequent assessment. Five evaluators classified whether the abstract was generated by a human using a 5‐point scale and provided justifications within seven aspects: formatting, information accuracy, orthography, punctuation, terminology, text fluency, and writing style. Furthermore, an online GPT detector provided “Human Score” values, and a plagiarism detector assessed similarity with existing literature.ResultsSensitivity values for detecting human writing ranged from 0.20 to 0.70, with a mean of 0.58; specificity values ranged from 0.40 to 0.90, with a mean of 0.62; and accuracy values ranged from 0.50 to 0.80, with a mean of 0.60. Orthography and Punctuation were the most indicated aspects for the abstract generated by ChatGPT. The GPT detector revealed confidence levels for a “Human Score” of 16.9% for the AI‐generated texts and plagiarism levels averaging 35%.ConclusionThe GPT exhibited commendable performance in generating scientific abstracts when evaluated by humans, as the generated abstracts were indistinguishable from those generated by humans. When evaluated by an online GPT detector, the use of GPT became apparent.
Multilevel Analysis of MYC and BCL2 Aberrations in Diffuse Large B‐Cell Lymphoma: Identifying a High‐Risk Patient Subgroup Across Cell‐of‐Origin Using Targeted Sequencing
Authors: Vimalathas Gayaththri , Lang Cecilie Steensboe , Green Tina Marie , Møller Michael Boe , Nyvold Charlotte Guldborg , Hansen Marcus Høy , Larsen Thomas Stauffer 
Published: November 2024

ABSTRACTIntroductionDiffuse large B‐cell lymphoma (DLBCL) exhibits striking clinical and biological heterogeneity. Recent studies have identified new subgroups within germinal center B‐cell like (GCB) DLBCL, associated with inferior prognosis, irrespective of MYC and BCL2 translocations. We explored the existence of such a DLBCL high‐risk subgroup, based on multilevel aberrations, especially focusing on MYC and BCL2.MethodsTissue samples from 111 DLBCL patients were sequenced with a 90‐gene lymphoma panel, followed by integrative analyses combining sequencing data, immunohistochemistry, fluorescent in situ hybridization, and clinical data.ResultsWe identified a high‐risk subgroup in DLBCL defined by: dual immunohistochemical MYC and BCL2 expression (DEL), concurrent MYC and BCL2 translocations (DHL‐BCL2), mutations in MYC, CXCR4, or both, and/or BCL2 amplification. The high‐risk subgroup constituted 41% of the cohort and included DHL‐BCL2, DEL, a GCB subgroup likely representing the recently described GCB subgroups, and a subset of non‐GCB patients. In multivariate analysis, high‐risk features provided independent predictive value from age and IPI. The 5‐year overall survival was 36% in high‐risk patients, compared to 76% in non‐high‐risk patients.ConclusionWe identified a distinct high‐risk DLBCL subgroup, characterized by MYC and BCL2 aberrations, beyond conventional DHL‐BCL2 and DEL, and irrespective of cell‐of‐origin, thereby expanding the poor‐prognosis group.
Serum neurofilament light chain predicts disease severity in axonal variants of acute immune neuropathies: A retrospective monocentric cohort study
Authors: Afzali Ali Maisam , Vosko Milan , Reinhardt Nya , Zinevych Iaroslav , Gmeiner Vincent , Korn Thomas , Gasperi Christiane , Berthele Achim , Feneberg Emily , Hemmer Bernhard 
Published: November 2024

AbstractBackground and purposeThe purpose was to explore the prognostic utility of neurofilament light chain (NfL) in patients with immune‐mediated polyradiculoneuropathies (IMPs).MethodsThis retrospective monocentric study analysed serum and cerebrospinal fluid samples from patients diagnosed with IMP collected prior to treatment initiation. NfL concentrations were correlated with clinical outcomes, including F score and hospitalization duration.ResultsAmongst 115 IMP patients tested, baseline cerebrospinal fluid and serum NfL (sNfL) concentrations were higher in acute inflammatory axonal polyradiculoneuropathy (AIAP) than other IMP variants. In the AIAP cohort, a positive correlation was observed between baseline sNfL concentrations, F score and hospitalization duration. Multivariate linear regression analysis further supported the predictive relationship between elevated baseline sNfL concentrations and clinical outcomes. Using receiver operating characteristic analysis, a cut‐off value for sNfL of 351 pg/mL was found to predict an F score >3 in AIAP with a sensitivity of 40% and specificity of 81.8%. AIAP patients with sNfL concentrations above this threshold required longer hospitalization (extended by 15 days).DiscussionOur findings highlight the potential of baseline sNfL as an effective marker for distinguishing between IMP variants and predicting the prognosis of AIAP. Further validation may facilitate translation of sNfL into clinical practice, potentially identifying high‐risk patients for tailored treatment approaches.
Bank Financial Distress and Stock Price Crashes: A Quasi‐Experimental Approach
Authors: Biswas Priti , Maitra Debasish , Mukherjee Sayantan 
Published: November 2024

ABSTRACTUsing 118,292 US bank‐month observations, we examine the effects of short‐term changes in bank's financial distress on stock price crash risk. There is a significant positive association between short‐term changes in distress on stock price crash risk. The results remain consistent across alternative measures of distress and crash risk. We confirm robustness by employing additional tests for reverse causality and propensity score matching. We find opacity, proxied by discretionary loan‐loss provisions to be a potential channel through which increase in distress affects future crash risk. Our study underscores the critical association between increasing financial distress, loan‐loss reporting, and crash risk.