bluuebunny/crossref_metadata_2025_split huggingface dataset:
α-Rank: Multi-Agent Evaluation by Evolution
Authors: Omidshafiei Shayegan , Papadimitriou Christos , Piliouras Georgios , Tuyls Karl , Rowland Mark , Lespiau Jean-Baptiste , Czarnecki Wojciech M. , Lanctot Marc , Perolat Julien , Munos Remi 
Published: July 2019

AbstractWe introduceα-Rank, a principled evolutionary dynamics methodology, for theevaluationandrankingof agents in large-scale multi-agent interactions, grounded in a novel dynamical game-theoretic solution concept calledMarkov-Conley chains(MCCs). The approach leverages continuous-time and discrete-time evolutionary dynamical systems applied to empirical games, and scales tractably in the number of agents, in the type of interactions (beyond dyadic), and the type of empirical games (symmetric and asymmetric). Current models are fundamentally limited in one or more of these dimensions, and are not guaranteed to converge to the desired game-theoretic solution concept (typically the Nash equilibrium).α-Rank automatically provides a ranking over the set of agents under evaluation and provides insights into their strengths, weaknesses, and long-term dynamics in terms of basins of attraction and sink components. This is a direct consequence of the correspondence we establish to the dynamical MCC solution concept when the underlying evolutionary model’s ranking-intensity parameter,α, is chosen to be large, which exactly forms the basis ofα-Rank. In contrast to the Nash equilibrium, which is a static solution concept based solely on fixed points, MCCs are a dynamical solution concept based on the Markov chain formalism, Conley’s Fundamental Theorem of Dynamical Systems, and the core ingredients of dynamical systems: fixed points, recurrent sets, periodic orbits, and limit cycles. Ourα-Rank method runs in polynomial time with respect to the total number of pure strategy profiles, whereas computing a Nash equilibrium for a general-sum game is known to be intractable. We introduce mathematical proofs that not only provide an overarching and unifying perspective of existing continuous- and discrete-time evolutionary evaluation models, but also reveal the formal underpinnings of theα-Rank methodology. We illustrate the method in canonical games and empirically validate it in several domains, including AlphaGo, AlphaZero, MuJoCo Soccer, and Poker.
A mathematical model to predict mean time to delivery following cervical ripening with dinoprostone vaginal insert
Authors: Levast Fanny , Legendre Guillaume , Hachem Hady El , Saulnier Patrick , Descamps Philippe , Gillard Philippe , Bouet Pierre-Emmanuel 
Published: July 2019

AbstractThe main objective of our study was to analyze the mean time to delivery following cervical ripening with a 10 mg dinoprostone vaginal insert. We performed a retrospective observational study at the level III maternity ward of Angers university hospital. We included all women who had cervical ripening with dinoprostone between January 1st, 2015 and September 30th, 2016. Overall, 405 patients were included, and 59.3% (240/405) were nulliparous. The mean time to delivery was 20h39 min ± 10h49 min. 21% of deliveries (86/405) occurred between midnight and 6 h a.m., and the cesarean section rate was 33% (132/405). Multiple regression analysis showed that nulliparity, overweight (BMI ≥ 25), a closed cervix on initial examination and the absence of premature rupture of membranes (PRM) all significantly increased the mean time to delivery. We developed a mathematical model integrating the aforementioned factors and their impact to help predict the mean time to delivery following cervical ripening with dinoprostone vaginal insert: Y = 961.188–80.346 × parity + 21.437 × BMI–165.263 × cervical dilation–241.759 × PRM. This equation allows obstetricians to calculate a personalized time to delivery for each patient, allowing a precise scheduling of dinoprostone insert placement, and thus improving the organization in busy maternity wards.
Plan Quality and Secondary Cancer Risk Assessment in Patients with Benign Intracranial Lesions after Radiosurgery using the CyberKnife M6 Robotic Radiosurgery System
Authors: Lan Jen-Hong , Shieh Chin-Shiuh , Liu Chao-Hong , Cho I-Chun , Tsai I-Hsing , Chen Long-Chun , Chao Pei-Ju , Lee Hsiao-Fei , Huang Yu-Jie , Lee Tsair-Fwu 
Published: July 2019

AbstractThis study was performed to examine the quality of planning and treatment modality using a CyberKnife (CK) robotic radiosurgery system with multileaf collimator (MLC)-based plans and IRIS (variable aperture collimator system)-based plans in relation to the dose–response of secondary cancer risk (SCR) in patients with benign intracranial tumors. The study population consisted of 15 patients with benign intracranial lesions after curative treatment using a CyberKnife M6 robotic radiosurgery system. Each patient had a single tumor with a median volume of 6.43 cm3 (range, 0.33–29.72 cm3). The IRIS-based plan quality and MLC-based plan quality were evaluated by comparing the dosimetric indices, taking into account the planning target volume (PTV) coverage, the conformity index (CI), and the dose gradient (R10% and R50%). The dose–response SCR with sarcoma/carcinoma induction was calculated using the concept of the organ equivalent dose (OED). Analyses of sarcoma/carcinoma induction were performed using excess absolute risk (EAR) and various OED models of dose–response type/lifetime attributable risk (LAR). Moreover, analyses were performed using the BEIR VII model. PTV coverage using both IRIS-based plans and MLC-based plans was identical, although the CI values obtained using the MLC-based plans showed greater statistical significance. In comparison with the IRIS-based plans, the MLC-based plans showed better dose falloff for R10% and R50% evaluation. The estimated difference between Schneider’s model and BEIR VII in linear-no-threshold (Lnt) cumulative EAR was about twofold. The average values of LAR/EAR for carcinoma, for the IRIS-based plans, were 25% higher than those for the MLC-based plans using four SCR models; for sarcoma, they were 15% better in Schneider’s SCR models. MLC-based plans showed slightly better conformity, dose gradients, and SCR reduction. There was a slight increase in SCR with IRIS-based plans in comparison with MLC-based plans. EAR analyses did not show any significant difference between PTV and brainstem analyses, regardless of the tumor volume. Nevertheless, an increase in target volume led to an increase in the probability of SCR. EAR showed statistically significant differences in the soft tissue according to tumor volume (1–10 cc and ≥10 cc).
Reversine exhibits antineoplastic activity in JAK2V617F-positive myeloproliferative neoplasms
Authors: Lima Keli , Carlos Jorge Antonio Elias Godoy , Alves-Paiva Raquel de Melo , Vicari Hugo Passos , Souza Santos Fábio Pires de , Hamerschlak Nelson , Costa-Lotufo Leticia Veras , Traina Fabiola , Machado-Neto João Agostinho 
Published: July 2019

AbstractJAK2/STAT signaling participates in the Ph-negative myeloproliferative neoplasms (MPN) pathophysiology and has been targeted by ruxolitinib, a JAK1/2 inhibitor. In the present study, the impact of ruxolitinib treatment on cytoskeleton-related genes expression was explored. In SET2 cells, AURKA and AURKB expression/activity were downregulated in a dose- and time-dependent manner by ruxolitinib. Reversine, a multikinase inhibitor selective for aurora kinases, reduced cell viability in a dose- and/or time-dependent manner in JAK2V617Fcells. Reversine significantly increased apoptosis and mitotic catastrophe, and reduced cell proliferation and clonogenic capacity in SET2 and HEL cells. In the molecular scenario, reversine induced DNA damage and apoptosis markers, as well as, reduced AURKA and AURKB expression/activity. In SET2 cells, reversine modulated the expression of 32 out of 84 apoptosis-related genes investigated, including downregulation of antiapoptotic (BCL2,BCL2L1, andBIRC5) and upregulation of proapoptotic (BIK,BINP3, andBNIP3L) genes. Synergism experiments indicated that low dose of reversine had a potentiating effect under ruxolitinib treatment at low doses in SET2 cells. In summary, our exploratory study establishes new targets, related to the regulation of the cellular cytoskeleton, for potential pharmacological intervention in MPN. These findings indicate that AURKA and AURKB participate in the JAK2/STAT signaling pathway and contribute to the MPN phenotype.
Swept-Source Optical Coherence Tomography Biometer as Screening Strategy for Macular Disease in Patients Scheduled for Cataract Surgery
Authors: Tognetto Daniele , Pastore Marco R. , De Giacinto Chiara , Merli Riccardo , Franzon Marco , D’Aloisio Rossella , Belfanti Lorenzo , Giglio Rosa , Cirigliano Gabriella 
Published: July 2019

AbstractThe aim of this study was to assess the central macular imaging captured with an optical biometer based on full-eye-length Swept-Source OCT (SS-OCT) scan as a screening strategy for identifying macular diseases in patients scheduled for cataract surgery. 1,114 eyes of 749 consecutive patients underwent a biometrical examination with IOLMaster 700 SS-OCT technology (Carl Zeiss) and conventional Spectral-Domain OCT (SD-OCT) (Spectralis OCT, Heidelberg) device analysis on the same day. Seven examiners graded the scans individually in a full-masked mode. Twenty-five eyes were excluded for media opacities. Among the 1,089 included eyes, statistical analysis revealed a mean Kendall’s Coefficient of 0.83 (range 0.76–0.89). A logistic regression model demonstrated a highly significant correlation (p < 0.001) between the coefficient of concordance and SD-OCT imaging. Intraobserver reproducibility was 0.89 (range 0.86–0.91). Optical biometer SS-OCT scans showed a mean sensitivity of 0.81 and a mean specificity of 0.84. The positive and negative predictive value detected was 0.78 and 0.86, respectively. In order to predict the risk of reduced visual recovery, especially in cases of retinal pathology, optical biometer with SS-OCT scan has proven to be a useful modality for detecting macular structural abnormalities in patients undergoing cataract surgery. Conventional SD-OCT remains mandatory to confirm the presumed diagnosis.
Origins of Negative Differential Resistance in N-doped ZnO Nano-ribbons: Ab-initio Investigation
Authors: Shaheen Alaa , Ali Muhammad , Othman Wael , Tit Nacir 
Published: July 2019

AbstractThe electronic transport in low-dimensional materials is controlled by quantum coherence and non-equilibrium statistics. The scope of the present investigation is to search for the origins of negative-differential resistance (NDR) behavior in N-doped ultra-narrow zigzag-edge ZnO nano-ribbons (ZnO-NRs). A state-of-the-art technique, based on a combination of density-functional theory (DFT) and non-equilibrium Green’s function (NEGF) formalism, is employed to probe the electronic and transport properties. The effect of location of N dopant, with respect to the NR edges, on IV-curve and NDR is tested and three different positions for N-atom are considered: (i) at the oxygen-rich edge; (ii) at the center; and (iii) at the Zn-rich edge. The results show that both resistance and top-to-valley current ratio (TVCR) reduce when N-atom is displaced from O-rich edge to center to Zn-rich edge, respectively. After an analysis based on the calculations of transmission coefficient versus bias, band structures, and charge-density plots of HOMO/LUMO states, one is able to draw a conclusion about the origins of NDR. The unpaired electron of N dopant is causing the curdling/localization of wave-function, which in turn causes strong back-scattering and suppression of conductive channels. These effects manifest themselves in the drawback of electric current (or so called NDR). The relevance of NDR for applications in nano-electronic devices (e.g., switches, rectifiers, amplifiers, gas sensing) is further discussed.
Identification of ryuvidine as a KDM5A inhibitor
Authors: Mitsui Eishin , Yoshida Shogo , Shinoda Yui , Matsumori Yasumasa , Tsujii Hiroshi , Tsuchida Mie , Wada Shuichi , Hasegawa Makoto , Ito Akihiro , Mino Koshiki , Onuki Tetsuo , Yoshida Minoru , Sasaki Ryuzo , Mizukami Tamio 
Published: July 2019

AbstractKDM5 family members (A, B, C and D) that demethylate H3K4me3 have been shown to be involved in human cancers. Here we performed screening for KDM5A inhibitors from chemical libraries using the AlphaScreen method and identified a battery of screening hits that inhibited recombinant KDM5A. These compounds were further subjected to cell-based screening using a reporter gene that responded to KDM5A inhibition and 6 compounds were obtained as candidate inhibitors. When further confirmation of their inhibition activity on cellular KDM5A was made by immunostaining H3K4me3 in KDM5A-overexpressing cells, ryuvidine clearly repressed H3K4me3 demethylation. Ryuvidine prevented generation of gefitinib-tolerant human small-cell lung cancer PC9 cells and also inhibited the growth of the drug-tolerant cells at concentrations that did not affect the growth of parental PC9 cells. Ryuvidine inhibited not only KDM5A but also recombinant KDM5B and C; KDM5B was the most sensitive to the inhibitor. These results warrant that ryuvidine may serve as a lead compound for KDM5 targeted therapeutics.
MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase
Authors: Gao Hui , Chen Jiwang , Chen Tianji , Wang Yifang , Song Yang , Dong Yangbasai , Zhao Shuangping , Machado Roberto F. 
Published: July 2019

AbstractNicotinamide phosphoribosyltransferase (NAMPT) upregulation in human pulmonary artery endothelial cells (hPAECs) is associated with pulmonary arterial hypertension (PAH) progression and pulmonary vascular remodeling. The underlying mechanisms regulating NAMPT expression are still not clear. In this study, we aimed to study the regulation of NAMPT expression by microRNA410 (miR410) in hPAECs and explore the role of miR410 in the pathogenesis of experimental pulmonary hypertension. We show that miR410 targets the 3′ UTR of NAMPT and that, concomitant with NAMPT upregulation, miR410 is downregulated in lungs of mice exposed to hypoxia-induced pulmonary hypertension (HPH). Our results also demonstrate that miR410 directly inhibits NAMPT expression. Overexpression of miR410 in hPAECs inhibits basal and VEGF-induced proliferation, migration and promotes apoptosis of hPAECs, while miR410 inhibition via antagomirs has the opposite effect. Finally, administration of miR410 mimics in vivo attenuated induction of NAMPT in PAECs and prevented the development of HPH in mice. Our results highlight the role of miR410 in the regulation of NAMPT expression in hPAECs and show that miR410 plays a potential role in PAH pathobiology by targeting a modulator of pulmonary vascular remodeling.
Effectiveness of simple tracing test as an objective evaluation of hand dexterity
Authors: Nishi Tomohiro , Fukudome Kiyohiro , Hata Kazutaka , Kawaida Yutaka , Yone Kazunori 
Published: July 2019

AbstractThis study aimed to demonstrate that the simple tracing test (STT) is useful for assessing the hand dexterity in patients with cervical spondylotic myelopathy (CSM) by comparing STT scores between healthy volunteers and CSM patients. This study included 25 CSM patients and 38 healthy volunteers. In the STT, the participants traced a sine wave displayed on a tablet device at a comfortable pace, and the tracing accuracy, changes in the total sum of pen pressures, and tracing duration were assessed. Data were analyzed using an artificial neural networks (ANN) model to obtain STT scores. All participants were evaluated using the subsection for the upper extremity function of the Japanese Orthopaedic Association (JOA) scoring system for cervical myelopathy (JOA subscore for upper extremity function) and the grip and release test (GRT). The results were compared with the STT scores. The mean STT scores were 24.4 ± 32.8 in the CSM patients and 84.9 ± 31.3 in the healthy volunteers, showing a significant difference. The STT scores showed highly positive correlations with both the JOA subscore for upper extremity function (r = 0.66; P < 0.001) and GRT values (r = 0.74; P < 0.001). Furthermore, receiver operating characteristic analysis showed an area under the curve of 0.89 (95% confidence interval, 0.76–1.00), demonstrating that STT has excellent discriminative ability. This study revealed that STT enables accurate assessment of the hand dexterity in CSM patients.
The opening of phenome-assisted selection era in the early seedling stage
Authors: Kim Song Lim , Chung Yong Suk , Silva Renato Rodrigues , Ji Hyeonso , Lee Hongseok , Choi Inchan , Kim Nyunhee , Lee Eungyeong , Baek JeongHo , Lee Gang-Seob , Kwon Taek-Ryoun , Kim Kyung-Hwan 
Published: July 2019

AbstractFaster and more efficient breeding cycle is not an option to deal with unpredictable and fast global climate changes. Phenomics for collecting huge number of individuals in accurate manner could be an answer to solve this problem. We collected image data to measure plant height and manual data for shoot length to be compared. QTLs clustered of plant height and shoot length were detected in 2-week old seedlings, which was consistent with many other reports using various genetic resources in matured stage. Further, these traits are highly correlated with yield by pleiotropism or tight linkage of those traits. It implies the “phenome-assisted selection” can be applied for yield trait in rice in the very early stage to shorten the breeding cycle significantly in fast but low-cost manner.
LncRNA AWPPH overexpression predicts the recurrence of periodontitis
Authors: Wang Xiaofang , Ma Feng , Jia Peizeng 
Published: July 2019

Abstract
Long non-coding RNA (LncRNA) AWPPH is a recently identified oncogenic lncRNA, while its role in other human diseases is still unknown. Blood samples from 80 periodontitis (periodontitis group) patients and 66 healthy controls (control group) who were admitted and treated by Peking University School and Hospital of Stomatology, expression levels of lncRNA AWPPH were detected by RT-PCR. In the present study, we showed that, before treatment, lncRNA AWPPH in plasma was up-regulated in periodontitis patients than in healthy controls. After treatment, expression levels of lncRNA AWPPH reduced significantly. Patients were followed up for 2 years to recorded recurrence. Compared with plasma levels of lncRNA AWPPH on the day of discharge, lncRNA AWPPH expression level increased significantly in patients with recurrence but not in patients without recurrence during follow-up. Based on Youden’s index, patients were divided into high and low lncRNA AWPPH groups according to its expression level on the day of discharge. It was observed that the recurrence rate of periodontitis is significantly higher in high lncRNA AWPPH group than in low lncRNA AWPPH group. LncRNA AWPPH overexpression predicts the recurrence of periodontitis.
Multi-wavelength campaign on NGC 7469
Authors: Grafton-Waters S. , Branduardi-Raymont G. , Mehdipour M. , Page M. J. , Behar E. , Kaastra J. , Arav N. , Bianchi S. , Costantini E. , Ebrero J. , Di Gesu L. , Kaspi S. , Kriss G. A. , De Marco B. , Mao J. , Middei R. , Peretz U. , Petrucci P.-O. , Ponti G. 
Published: July 2019

Aims.We aim to investigate and characterise the photoionised X-ray emission line regions within the Seyfert 1 galaxy NGC 7469.Methods.We applied the photoionisation model,PION, within the spectral fitting codeSPEXto analyse the 640 ks reflection grating spectrometer spectrum of NGC 7469 gathered during anXMM-Newtonobserving campaign in 2015.Results.We find the emission line region in NGC 7469 to be multiphased, consisting of two narrow components with ionisation parameters of logξ = 0.4 and 1.6. A third, broad emission component, with a broadening velocity ofvb ∼ 1400 km s−1and an outflow velocity ofvout ∼ −4500 km s−1is required to fit the residuals in the O VIItriplet at around 22 Å. Assuming a volume filling factor of 0.1, the lower distance limits of the narrow emission line region components are estimated for the first time at 2.6 and 2.5 pc from the central black hole, whereas the broad component has an estimated lower bound distance between 0.004 and 0.03 pc, depending on the assumed plasma parameters. The collisionally ionised plasma from the star burst region in NGC 7469 has a plasma temperature of 0.32 keV and an outflow velocity of −280 km s−1, which is consistent with previous results in this campaign. In addition, we model the photoionised plasma of the warm absorber (WA) in NGC 7469 and find that it consists of three photoionised phases with different values ofξ,NHandvout. The upper bound distances of these WA components are 1.9, 0.3, and 0.6 pc, respectively, consistent with archival results.Conclusion.The environment of NGC 7469 is a complex mix of plasma winds absorbing and emitting X-rays. We find the picture painted by our results can be attributed to line emitting plasma located at distances ranging from near the black hole to the torus and beyond the ionised outflows.
Attitudes thérapeutiques dans les cas de fermeture des espaces d’agénésie d’incisives latérales maxillaires chez l’enfant et l’adolescent
Authors: Le Gall Michel , Bachet Christophe , Chevalier Emilie , Dameron Cyril , Philip-Alliez Camille 
Published: July 2019

L’absence d’incisives latérales maxillaires est à l’origine de problèmes esthétiques, occlusaux et fonctionnels majeurs compte tenu de la position stratégique de celles-ci dans le sourire.
Les options thérapeutiques proposées sont l’abstention thérapeutique, la réouverture d’espaces et le remplacement prothétique, et la fermeture d’espaces par mésialisation des dents de l’arcade.
Cet article est centré sur la fermeture des espaces d’agénésies et propose différentes solutions thérapeutiques.
Mikrobiom & NASH – enge Komplizen in der Progression von Fettlebererkrankungen
Authors: Wree Alexander , Geisler Lukas Jonathan , Tacke Frank 
Published: July 2019

ZusammenfassungEinhergehend mit der steigenden Prävalenz von Übergewicht, metabolischem Syndrom und Typ-2-Diabetes nehmen nicht-alkoholische Fettlebererkrankungen (NAFLD) stark zu und stellen eine große Herausforderung in der Gastroenterologie dar. Viele Studien konnten nachweisen, dass das Mikrobiom in einem engen Zusammenhang mit der Progression von ernährungsbedingten Krankheitsbildern, insbesondere auch von Fettlebererkrankungen, steht. Veränderungen in der Quantität und Qualität der Darmflora, allgemein als Dysbiose bezeichnet, bedingen veränderte Metabolisierung von Nahrungsmitteln, erhöhte Permeabilität der Darmbarriere („leaky gut“) und konsekutiv Entzündungsprozesse in der Leber. Dies begünstigt sowohl das Fortschreiten von Adipositas und metabolischen Störungen als auch von NAFLD zur nicht-alkoholischen Steatohepatitis (NASH), hepatischen Fibrose, Leberzirrhose und hepatozellulärem Karzinom (HCC). Wichtige molekulare Mechanismen beinhalten mikrobielle Stoffwechselprodukte, mikrobielle und endogene Signalstoffe (sogenannte PAMPs/DAMPs) sowie Gallensäuren. Essenzielle zelluläre Mechanismen umfassen immunologische Zellen in Darm und Leber, insbesondere Makrophagen und Kupffer-Zellen, sowie Darmepithelzellen und Hepatozyten als zentrale Regulatoren des Stoffwechsels. In dieser Übersicht wollen wir anhand aktueller wissenschaftlicher Arbeiten und klinischer Studien kurz auf die relevanten Spezies des humanen Mikrobioms eingehen, die mikrobielle Analytik erläutern, die wichtigsten molekularen Zusammenhänge zwischen Mikrobiom und NAFLD/NASH erklären und schlussendlich Möglichkeiten der Mikrobiom-modulierenden Therapie zur Behandlung von Fettlebererkrankungen darlegen.