bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable modeling in reverse logistics strategies using fuzzy MCDM
Authors: Asees Awan Muhammad , Ali Yousaf 
Published: May 2019

PurposeGlobalization in supply chain networks is urging manufacturing companies for the production of sustainable products with re-engineering technologies that offer competitive advantage in current market. However, the increasing sustainable illumes are influencing reverse logistics (RL) systems to analyze their impacts on economy, environment and society. Recently, China’s $62bn investment under the egis of China Pakistan Economic Corridor (CPEC), which comprises a number of infrastructure and energy projects is developing Pakistan as a part of “One Belt One Road” initiative. Accordingly, a substantial number of economical, ecological and social exercises will occur in closest future. The purpose of this paper is to investigate the impact of sustainable practices, i.e., environmental, economic and social sustainability on RL recovery options.Design/methodology/approachSustainable concepts including environmental, economic and social and RL recovery options are extracted through extensive literature review. A number of researchers used a variety of methodologies for achieving their research objectives. However, the authors will be using a combination of VIsekriterijumska optimizacija i KOmpromisno Resenje (VIKOR) and grey relational analysis (GRA) technique under fuzzy environment in the case of CPEC.FindingsResults show that waste management, impact on bio-diversity and economic growth are the most significant factors in designing sustainable RL recovery options. Moreover, remanufacture and reuse rank top among RL recovery options due their significant economic and environmental effects, whereas recycle and resell position last due to their high cost and cutting edge modern technologies.Practical implicationsFinally based on this model, it is possible for authorities to design a sustainable RL strategy for efficient operations in case of CPEC projects and other developing countries as well.Originality/valueNegligible work has been done regarding sustainable modeling in RL strategies using a combination of VIKOR and GRA techniques subjected to fuzzy environment in the case of CPEC from perspective of developing country, i.e., Pakistan.
New methods of modeling and estimating preferences
Authors: Alghalith Moawia 
Published: May 2019

PurposeThis paper aims to quantify preferences without having to have any utility data.Design/methodology/approachWe use duality theory, Taylor’s theorem and nonlinear regressions.FindingsWe presented pioneering quantitative methods in economics and business. These methods can be applied to numerous topics in empirical and theoretical economics and business. Moreover, this paper highlighted the interdisciplinary nature of economics. In doing so, it emphasized the interface between economics, marketing, management, statistics and mathematics. Furthermore, it circumvented a major obstacle in the literature: the curse of dimensionality.Originality/valueThe authors introduce a novel and convenient approach to utility modeling. In doing so, they present a general utility function in a simple form. Furthermore, they develop a method to measure preferences without any utility data. They also devise a method to measure the marginal utility. Then, they develop new methods of modeling and measuring the consumer utility. In so doing, they overcome a major obstacle: the curse of the dimensionality. In addition, they introduce new methods of modeling and measuring the consumer demand for the firm’s good.
Demographics of sustainable technology consumption in an emerging market: the significance of education to energy efficient appliance adoption
Authors: Nguyen Ninh , Greenland Steven , Lobo Antonio , Nguyen Hoang Viet 
Published: May 2019

Purpose
This paper aims to address gaps in the sustainable technology literature by evaluating the demographics of energy efficient appliance consumption in Vietnam. Sustainable technologies can reduce greenhouse gas emissions and address environmental problems such as air quality and climate change. Opportunity is the greatest in emerging markets, where population growth has triggered dramatic rises in electricity consumption. However, their adoption of energy efficient appliances has been slow and understanding why is limited.

Design/methodology/approach
Following a literature review, a questionnaire was designed to capture sustainable consumption attitudes and behaviours. In total, 682 interviews were conducted among Vietnamese electrical appliance consumers to investigate the influence of demographics on sustainable technology consumption.

Findings
While many respondents were aware of the sustainable benefits of energy efficient appliances, this did not generally translate into responsible purchase behaviour. Of the demographic variables, education had the strongest relationship with sustainability. Those with higher incomes and more children were also more likely to exhibit sustainable consumption attitudes and behaviours. Gender and age were weaker sustainability predictors.

Originality/value
This study is relevant to a wide range of sustainable technology contexts. The literature shows contrary findings regarding relationships between demographics and sustainable consumption, and the value of demographics to sustainable consumer segmentation and targeted behaviour change campaigns has been contested by some researchers. This research highlights education as the most significant demographic predictor of sustainable consumption and reveals the consistency of this finding with many other studies. The implications of this for promoting future sustainability are discussed.
Strongly aligned coastal boulders on Ko Larn island (Thailand): a proxy for past typhoon‐driven high‐energy wave events in the Bay of Bangkok
Authors: Terry James P. , Goff James 
Published: May 2019

AbstractRecent studies of elevated carbonate boulder deposits on several rock islands near Bangkok have indicated that Thailand's capital city may not be as protected from typhoon strikes as previously thought. Here, new evidence is presented for past high‐energy wave (HEW) events in the form of statistically significant patterns of boulder alignment on exposed rocky shorelines of Ko Larn island. The long‐axis orientations of 193 coastal sandstone boulders were analysed across four study sites. Several scenarios for the unimodal, bimodal, and polymodal patterns found can be envisaged. Either the most recent HEW event was the strongest—in which case most clasts were rearranged unimodally (one observation site), or the strongest HEW event was earlier and subsequent weaker ones realigned only smaller boulders to produce bimodal or polymodal patterns (three observation sites). Inferred northeastward or eastward onshore flow directions are consistent with palaeo‐typhoons penetrating into the Bay of Bangkok on northwestward curving tracks. The calculated minimum flow velocities required to transport all sampled boulders are 5.5–7.8 m s−1, similar to other findings throughout the Asia‐Pacific region. It was observed that the absence of a fitted boulder geomorphology lends credence to the earlier proposed time frame of 150–200 years between typhoon phases in the upper Gulf of Thailand. The current work has provided additional insights into the characteristics of past HEW events that have a possibility of reoccurring again at some time in the future. Our findings continue to raise awareness for a reassessment of the risks of coastal hazards for the Chao Phraya River delta and densely populated Bangkok, for which storm surge modelling should be an urgent priority, so as to give better perceptions on how typhoon‐driven marine incursion would impact the city.
Interleukin‐10 gene polymorphism rs1800896 is associated with post‐bronchiolitis asthma at 11–13 years of age
Authors: Holster Annukka , Nuolivirta Kirsi , Törmänen Sari , Lauhkonen Eero , Teräsjärvi Johanna , Vuononvirta Juho , Koponen Petri , Helminen Merja , He Qiushui , Korppi Matti 
Published: May 2019

AbstractAimInterleukin‐10 (IL‐10) is an anti‐inflammatory cytokine that is involved with bronchiolitis and asthma. We evaluated associations between four IL‐10 polymorphisms, namely rs1800871, rs1800872, rs1800890 and rs1800896, and post‐bronchiolitis asthma in young adolescents.MethodsThe cohort consisted of 125 children hospitalised for bronchiolitis at Tampere University Hospital, Finland, in 2000–2004, at less than six months of age. At 11–13 years, asthma diagnoses and asthma‐presumptive symptoms, allergic rhinitis and use of inhaled corticosteroids (ICS) were registered. Data on the four polymorphisms and their genotypes, haplotypes and allele frequencies were analysed in relation to asthma, allergic rhinitis and asthma medication.ResultsThe variant IL‐10 rs1800896 genotype was associated with less persistent asthma at five to seven and 11–13 years of age (4.3 versus 15.2%, p = 0.04) than the wild genotype and less ICS use during the previous 12 months (5.4 versus 18.2%, p = 0.03), as was the variant allele G. Allele A was associated with more persistent asthma and ICS use. The significant differences between the variant and wild genotypes were lost in adjusted logistic regression, but the direction of the association remained.ConclusionIL‐10 rs1800896 gene polymorphism was associated with post‐bronchiolitis asthma at 11–13 years of age in children hospitalised for bronchiolitis at less than six months of age.
Resource abundance, market size, and the choice of technology
Authors: Zhou Haiwen 
Published: May 2019

AbstractHow resource abundance and market size affect the choice of increasing returns technologies is studied in an overlapping‐generations general equilibrium model in which manufacturing firms engage in oligopolistic competition. The model is surprisingly tractable. First, for the steady state, the wage rate, the level of technology, and capital stock are not affected by the amount of natural resources. An increase in the share of agricultural revenue going to natural resources leads to a lower wage rate and firms choose less advanced technologies. Second, an increase in market size increases the equilibrium wage rate, level of technology, and capital stock. Finally, other things equal, a country with a lower endowment of natural resources or a higher market size has a comparative advantage in producing the manufactured good.
Argyrin B, a non‐competitive inhibitor of the human immunoproteasome exhibiting preference for β1i
Authors: Allardyce Duncan J. , Bell Celia M. , Loizidou Eriketi Z. 
Published: May 2019

AbstractInhibitors of the proteasome have found broad therapeutic applications; however, they show severe toxicity due to the abundance of proteasomes in healthy cells. In contrast, inhibitors of the immunoproteasome, which is upregulated during disease states, are less toxic and have increased therapeutic potential including against autoimmune disorders. In this project, we report argyrin B, a natural product cyclic peptide to be a reversible, non‐competitive inhibitor of the immunoproteasome. Argyrin B showed selective inhibition of the β5i and β1i sites of the immunoproteasome over the β5c and β1c sites of the constitutive proteasome with nearly 20‐fold selective inhibition of β1i over the homologous β1c. Molecular modelling attributes the β1i over β1c selectivity to the small hydrophobic S1 pocket of β1i and β5i over β5c to site‐specific amino acid variations that enable additional bonding interactions and stabilization of the binding conformation. These findings facilitate the design of immunoproteasome selective and reversible inhibitors that may have a greater therapeutic potential and lower toxicity.
Economic Inequality is Associated with Long‐Term Harm on Adolescent Well‐Being in China
Authors: Du Hongfei , Chi Peilian , King Ronnel B. 
Published: May 2019

Economic inequality has been found to be detrimental to psychological well‐being. However, previous studies were mostly based on cross‐sectional data, drew exclusively on adults, and confined to Western developed countries. To address these shortcomings, the current study investigated the longitudinal association of income inequality with adolescent psychological well‐being in a non‐Western developing economy (i.e., China). We used the China Family Panel Studies data set with a representative sample of 3,042 adolescents (Mage = 12.59) from 20 provinces in China. Analyses showed that adolescents in more unequal provinces had lower happiness and more psychological distress. The associations between economic inequality and well‐being varied across adolescents from different socioeconomic strata.
Is tooth loss important when evaluating perceived general health? Findings from a nationally representative study of Costa Rican adults
Authors: Barboza‐Solís Cristina , Porras‐Chaverri Mariela , Fantin Romain 
Published: May 2019

AbstractObjectivesAlthough previous studies have shown that oral diseases can impact certain systemic conditions, dental care has been historically separated from medical healthcare organizations in middle‐income countries. There is a lack of research approaches which test the independent relationship between oral health and multidimensional measures of general health. This study analyses the influence of tooth loss on self‐rated health (SRH), hypothesizing that, relatively to certain morbidity conditions, tooth loss is a health condition associated with SRH. This study analyses the influence of tooth loss on self‐rated health (SRH), hypothesizing that, relative to certain morbidity conditions, tooth loss is a health condition associated with SRH.MethodsData were obtained from the Costa Rican Longevity and Healthy Aging Study 1945‐1955 Retirement Cohort, a national representative longitudinal survey including residents born between 1945 and 1955. The association between severe tooth loss and SRH was analysed cross‐sectionally using the first wave of the study conducted in 2010. A multivariable logistic regression, adjusted for potential confounders, was performed on 2797 participants. A counterfactual analysis was additionally performed to illustrate the theoretical change on SRH prevalence—if all the participants were not to have had severe tooth loss.ResultsSevere tooth loss was associated with poor SRH, after adjustment for smoking, morbidity, biomarkers and performance‐based physical measures. The counterfactual analysis showed that severe tooth loss was the fifth most important morbidity condition in determining poor SRH. Declaring a poor SRH would have been decreased by 2.0 percentage points if those participants having severe tooth loss had shared the same risk pattern of those who had not lost the majority of their teeth.ConclusionIndividuals consider their oral health status to a similar extent as other morbidity conditions when evaluating their general health. A stronger focus on oral health, and its impact on general health, could lead to better planning of national resources, thereby improving accessibility to health care and modifying prevailing conceptions of health care in low‐ and middle‐income countries.
The End of the African Mining Enclave? Domestic Marginalization and Labour Fragmentation in the Democratic Republic of Congo
Authors: Radley Ben 
Published: May 2019

ABSTRACTAfrica‐focused global value chain (GVC) scholars argue that the new mining industry practice of corporate outsourcing invalidates the traditional enclave thesis by providing new opportunities to support domestic firms and stimulate industrialization. However, this literature has clustered around Africa's middle‐ and high‐income countries and its analytical approach abandons the centre–periphery framework within which its earlier antecedents were grounded, while overlooking labour dynamics. Correcting for these limitations, this article explores the GVC literature's claims through a single case study of a gold mine in the Democratic Republic of Congo, representative of a process of foreign‐controlled gold sector (re)industrialization underway across a group of 20 low‐income African countries. The findings confirm rather than invalidate the original enclave thesis, observing that corporate outsourcing has done little to stimulate broader industrialization while facilitating the arrival and expansion of foreign firm subsidiaries. Meanwhile, the new industry practice has also facilitated the adverse incorporation and fragmentation of Congolese labour, thus weakening the collective strength of workers. The findings demonstrate the value of expanding the conventional GVC framework to incorporate a consideration of peripherality and the capitalist labour process, and demonstrate the need for state intervention via pro‐labour and industrial policy.
Survival in adult acute lymphoblastic leukaemia (ALL): A report from the Swedish ALL Registry
Authors: Lennmyr Emma , Karlsson Karin , Ahlberg Lucia , Garelius Hege , Hulegårdh Erik , Izarra Antonio S , Joelsson Joel , Kozlowski Piotr , Moicean Andreea , Tomaszewska‐Toporska Beata , Lübking Anna , Hallböök Helene ,   On behalf of the Swedish Adult Acute Lymphoblastic Leukaemia Group (SVALL)
Published: May 2019

AbstractObjectivesAs new, effective therapies emerge for acute lymphoblastic leukaemia (ALL), the results of clinical trials need to relate to standard of care.MethodsWe used the population‐based Swedish ALL Registry to evaluate characteristics, treatment and long‐term outcome in 933 patients with diagnosis between 1997 and 2015.ResultsThe median age was 53 years. The frequency of Philadelphia (Ph)‐positive leukaemia was 34% of examined B‐ALL with a peak incidence at 50‐59 years. Five‐year overall survival (OS) improved between 1997‐2006 and 2007‐2015; in patients 18‐45 years from 50% (95% CI 43‐57) to 65% (95% CI 58‐72), 46‐65 years from 25% (95% CI 18‐32) to 46% (95% CI 37‐55) and >65 years from 7% (95% CI 2.6‐11) to 11% (95% CI 5.9‐16) (P < 0.05). Men with Ph‐neg B‐ALL 46‐65 years had inferior OS compared with women (P < 0.01). Standardised mortality ratio was 5.7 (95% CI 5.0‐6.3) for patients who survived 5 years from diagnosis. In multivariable analysis, Ph‐positive disease was not associated with impaired prognosis but with lower risk of death in 2007‐2015.ConclusionsIn a population‐based cohort, OS has improved in adult ALL, especially for Ph‐positive disease but for middle‐aged men with Ph‐negative B‐ALL outcome was poor. Cure without late toxicity or relapse is still desired.
Evolution and function of multimodal courtship displays
Authors: Mitoyen Clémentine , Quigley Cliodhna , Fusani Leonida 
Published: May 2019

AbstractCourtship displays are behaviours aimed to facilitate attraction and mating with the opposite sex and are very common across the animal kingdom. Most courtship displays are multimodal, meaning that they are composed of concomitant signals occurring in different sensory modalities. Although courtship often strongly influences reproductive success, the question of why and how males use multimodal courtship to increase their fitness has not yet received much attention. Very little is known about the role of different components of male courtship and their relative importance for females. Indeed, most of the work on courtship displays have focused on effects on female choice, often neglecting other possible roles. Additionally, a number of scientists have recently stressed the importance of considering the complexity of a display and the interactions between its different components in order to grasp all the information contained in those multimodal signals. Unfortunately, these methods have not yet been extensively adapted in courtship studies. The aim of this study was to review what is currently known about the functional significance of courtship displays, particularly about the role of multimodality in the courtship communication context. Emphasis is placed on those cases where a complete picture of the communication system can only be assessed by taking complexity and interaction between different modalities into account.
Implication of myeloid differentiation factor 88 inhibitor TJ‐M2010‐5 for therapeutic intervention of hepatocellular carcinoma
Authors: Liu Jing , Zhang Xue , Wang Haizhou , Zhang Meng , Peng Yanan , Li Mingqiang , Xie Lin , Jiang Fengchao , Gong Yiping , Zhao Qiu , Zhou Ping 
Published: May 2019

AimMyeloid differentiation factor 88 (MyD88) plays a key role in tumor proliferation and metastasis. Targeting MyD88 is a potent strategy in tumor therapy. TJ‐M2010‐5 is a small molecule derivative of aminothiazole and could inhibit dimer formation of MyD88. To explore the potential of TJ‐M2010‐5 in tumor therapy, we determined its antitumor effect and correlate mechanisms of TJ‐M2010‐5 in hepatocellular carcinoma (HCC).MethodsThe antitumor effect of intratumoral injection of TJ‐M2010‐5 to H22 tumor‐bearing BALB/c mice was observed. Tumor growth was monitored. The expression of MyD88 and Ki‐67 were detected by immunofluorescence. In vitro, the impacts of TJ‐M2010‐5 on proliferation, cell cycle, necrosis, and apoptosis of H22 cells were evaluated. The direct and indirect effects of TJ‐M2010‐5 on macrophages were evaluated using flow cytometry.ResultsTJ‐M2010‐5 induced both G0/G1 and G1/S phase arrests in HCC cells. Mechanically, downstream activation of MyD88 was suppressed by TJ‐M2010‐5 through the extracellular regulated protein kinase‐1/2/p90 ribosomal S6 kinase/glycogen synthase kinase‐3β signaling pathway. In turn, cyclin‐dependent kinase (CDK)6/cyclin D1 and CDK2/cyclin E complexes were downregulated. More importantly, TJ‐M2010‐5 significantly inhibited tumor growth in mice. Additionally, the portion of antitumor M1 macrophages (F4/80+CD11c+) in the tumor microenvironment were increased after TJ‐M2010‐5 treatment. Together, these data indicate that TJ‐M2010‐5 is a promising therapeutic drug for HCC.ConclusionsThese results indicate that MyD88 is a feasible target for antitumor treatment and TJ‐M2010‐5 is a qualified candidate for HCC therapy.
Favorable outcome with direct‐acting antiviral treatment in hepatitis C patients coinfected with HIV
Authors: Ishida Hisashi , Ishihara Akio , Tanaka Satoshi , Iwasaki Tetsuya , Hasegawa Hiroko , Akasaka Tomofumi , Sakakibara Yuko , Nakazuru Shoichi , Uehira Tomoko , Shirasaka Takuma , Mita Eiji 
Published: May 2019

AimTo investigate the efficacy and safety of all‐oral direct‐acting antiviral treatments in patients coinfected with hepatitis C virus (HCV) and HIV.MethodsIn all, 35 patients with HCV/HIV coinfection (22 patients with HCV genotype 1 infection, 6 with genotype 2, and 7 with genotype 3) were treated with sofosbuvir and ledipasvir (for genotype 1 patients) or sofosbuvir and ribavirin (for genotypes 2 and 3). Sustained virological response (SVR) at 24 weeks after end of treatment and adverse events were assessed.ResultsThe overall SVR rate was 91.4% (32/35). One patient with genotype 1 infection discontinued treatment on day 2 due to severe headache, which subsided after the cessation of medication; all other patients completed their treatment without severe adverse events. Two patients who had a relapse of HCV were infected with a genotype 3 strain. We observed hyperbilirubinemia in a patient with genotype 3, who was under antiretroviral therapy including atazanavir. He completed the treatment and achieved SVR.ConclusionDirect‐acting antiviral treatment for patients coinfected with HCV/HIV is as effective as in patients infected only with HCV. It was generally well tolerated, except in one patient who discontinued the treatment due to severe headache.