bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol‐based deep eutectic solvent as a carrier of SiO2@Fe3O4 for the development of magnetic dispersive micro‐solid‐phase extraction method: Application for the preconcentration and determination of morin in apple and grape juices, diluted and acidic extract of dried onion and green tea infusion samples
Authors: Majidi Seyedeh Maedeh , Hadjmohammadi Mohammad Reza 
Published: June 2019

AbstractIn this study, a hydrophilic deep eutectic solvent was synthesized as a carrier and disperser of magnetic nanoparticles based on ferrofluid and used to develop the dispersive micro‐solid‐phase extraction method. Ethylene glycol/tetramethylammonium chloride deep eutectic solvent and SiO2@Fe3O4 were used to provide the highly stable ferrofluid with strong sorbing properties without any additional stabilizer, which was employed to extract and determine morin in apple and grape juices, diluted and acidic extract of dried onion, and green tea infusion samples. The dispersibility of SiO2@Fe3O4 and prevention of its aggregation in the sample solution were improved using the deep eutectic solvent‐based ferrofluid. Also, it facilitated the fast injection of sorbent into the sample solution that led to an increase of the contact surface between the sorbent and analyte, and reduction of the extraction time and consumption of the sorbent. The important experimental parameters influencing the extraction efficiency of morin were examined. Under the optimal conditions, a linear calibration curve was obtained in the range of 3–500 µg/L with a determination coefficient of 0.9994. The limits of detection and quantification were of 0.91 and 2.98 µg/L, respectively. While an extraction recovery of 97.7% with relative standard deviation of 3.8% (interday) was obtained via three replicated measurements on a 30 µg/L of morin standard solution, the enrichment factor was 39.1. Finally, this method was successfully used to extract and preconcentrate morin in various samples, followed with their determination by high‐performance liquid chromatography with ultraviolet detection.
CiteScore metrics: Creating journal metrics from the Scopus citation index
Authors: James Chris , Colledge Lisa , Meester Wim , Azoulay Norman , Plume Andrew 
Published: June 2019

Key points
CiteScore was developed to implement familiar calculations but make them more comprehensive and transparent.
The justification for a new metric was to complement existing information to allow for comparison and evaluation.
CiteScore is available for all newly indexed journals with a publication history of 1 year.
CiteScore Tracker is updated monthly to show progress towards the annual snapshot CiteScore.
Feedback helps CiteScore develop, for example, by improving the management of title changes.
CiteScore provided metrics for 23,350 journals in 2018.
Modulation of Amplified Spontaneous Emissions between Singlet Fluorescence and Triplet Phosphorescence Channels in Organic Dye Lasers
Authors: Li Shuai , Yu Zhenyi , Xiao Xiaoxiao , Geng Hua , Wang Kai , Jin Xue , Liao Qing , Liao Yi , Wu Yishi , Yao Jiannian , Fu Hongbing 
Published: June 2019

AbstractOrganic gain materials (OGMs) currently used in dye lasers and organic thin‐film amplifiers are limited to singlet‐fluorescence molecules. Although heavy‐metal‐containing phosphorescent emitters enable highly efficient organic light‐emitting diodes, phosphorescent OGMs capable of light amplification by stimulated emission from triplet states remain largely unexplored. Demonstrated herein is the first phosphorescent dye laser from a pure organic luminescent rotor (1), composed of electron‐donating sulfide‐substituted difluoroboron (SBF2) and electron‐accepting nitrobenzene (NB) moieties. Furthermore, modulation of amplified spontaneous emissions (ASEs) between singlet fluorescence and triplet phosphorescence channels is achieved by adjusting the relative rotation (dihedral angle θ) of the donor and acceptor moieties. Theoretical calculations and experimental results clarify that free and restricted rotor rotation regulates the T2 state below and above the S1 state, thus switching on and off the intersystem crossing from S1 to the high‐lying T2 for phosphorescence and fluorescence, respectively. Based on this strategy, methyl groups are added on the NB moiety to increase the steric hindrance in 2, leading to tunable phosphorescence and/or fluorescence ASE. The results extend the scope of organic dye lasers and provide a strategy to develop phosphorescence OGMs capable of amplifying light through ASE from the triplet state.
Broad‐leaved forest types affect soil fungal community structure and soil organic carbon contents
Authors: Sheng Yuyu , Cong Jing , Lu Hui , Yang Linsen , Liu Qiang , Li Diqiang , Zhang Yuguang 
Published: June 2019

AbstractEvergreen broad‐leaved (EBF) and deciduous broad‐leaved (DBF) forests are two important vegetation types in terrestrial ecosystems that play key roles in sustainable biodiversity and global carbon (C) cycling. However, little is known about their associated soil fungal community and the potential metabolic activities involved in biogeochemical processes. In this study, soil samples were collected from EBF and DBF in Shennongjia Mountain, China, and soil fungal community structure and functional gene diversity analyzed based on combined Illumina MiSeq sequencing with GeoChip technologies. The results showed that soil fungal species richness (p = 0.079) and fungal functional gene diversity (p < 0.01) were higher in DBF than EBF. Zygomycota was the most dominant phylum in both broad‐leaved forests, and the most dominant genera found in each forest varied (Umbelopsis dominated in DBF, whereas Mortierella dominated in EBF). A total of 4, 439 soil fungi associated functional gene probes involved in C and nitrogen (N) cycling were detected. Interestingly, the relative abundance of functional genes related to labile C degradation (e.g., starch, pectin, hemicellulose, and cellulose) was significantly higher (p < 0.05) in DBF than EBF, and the functional gene relative abundance involved in C cycling was significantly negatively correlated with soil labile organic C (r = −0.720, p = 0.002). In conclusion, the soil fungal community structure and potential metabolic activity showed marked divergence in different broad‐leaved forest types, and the higher relative abundance of functional genes involved in C cycling in DBF may be caused by release of loss of organic C in the soil.
Physiological Concentrations of Blueberry‐Derived Phenolic Acids Reduce Monocyte Adhesion to Human Endothelial Cells
Authors: Tang Jeffry S. , Bozonet Stephanie M. , McKenzie Judith L. , Anderson Robert F. , Melton Laurence D. , Vissers Margreet C. M. 
Published: June 2019

ScopeBlueberry polyphenols are thought to confer cardiovascular health benefits, but have limited bioavailability. They undergo extensive metabolism and their phenolic acid metabolites are likely to be the mediators of bioactivity. The effect of blueberry‐derived phenolic acids on one aspect of inflammation, monocyte adhesion to vascular endothelial cells, is investigated.Methods and resultsThe major blueberry‐derived phenolic acids in human plasma are identified and quantified. Three test mixtures representing compounds present at 0–4 h (Early), 4–24 h (Late), or 0–24 h (Whole) are used to investigate the effect on adhesion of monocytes to tumor necrosis factor alpha (TNFα)–activated endothelial cells. The Late mixture reduces monocyte adhesion, but there is no effect of the Early or Whole mixtures. Exclusion of syringic acid from each mixture results in inhibition of monocyte adhesion. Exposure to the phenolic acid mixtures has no effect on the endothelial surface expression of adhesion molecules intercellular cell adhesion molecule‐1 (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1), or E‐selectin, suggesting that other molecular mechanisms are responsible for the observed effect.ConclusionThis study shows that physiological concentrations of blueberry polyphenol metabolites can help maintain cardiovascular health by regulating monocyte adhesion to the vascular endothelium.
Proteomic analysis of seminal extracellular vesicle proteins involved in asthenozoospermia by iTRAQ
Authors: Lin Yu , Liang Ajuan , He Yue , Li Zhengzheng , Li Zhenhua , Wang Guishuan , Sun Fei 
Published: June 2019

AbstractAsthenozoospermia is a common cause of male infertility, but in most cases its etiology is unknown. The exocytic cell vesicles called seminal extracellular vesicles in the human seminal fluid have been reported to play a pivotal role in promoting the motility of spermatozoa, and functional disorder of seminal extracellular vesicles may cause male infertility. To determine whether abnormal seminal extracellular vesicles are involved in asthenozoospermia, the differential abundance proteins between normozoospermic (NSEV) and asthenozoospermic seminal extracellular vesicles (ASEV) samples were analyzed by iTRAQ coupled with two‐dimensional liquid chromatography–tandem mass spectrometry. A total of 3,699 proteins were identified in the seminal extracellular vesicles (false discovery rate <0.01). Overall, 11 proteins were significantly upregulated (>1.2) in ASEV and 80 were significantly downregulated (<0.833). Functional bioinformatic analysis showed that these proteins with differential abundance were mainly associated with transport, metabolism, and signal pathways. The changes of OPTN, SMYD2, EIF2B2, TRPV6, ACE, PRSS8, and PPAP2A in ASEV were verified by western blot analysis, and we found that the abundance of TRPV6 markedly reduced in the seminal extracellular vesicles and ejaculated spermatozoa of asthenozoospermic patients, which indicated trpv6 was important in sperm motility. This study provides deeper insight into the involvement of seminal extracellular vesicles in asthenozoospermia and should aid the search for novel biomarkers of male infertility.
To stage or not to stage?—A cost minimization analysis of sacral neuromodulation placement strategies
Authors: Sun Andrew J. , Harris Catherine R. , Comiter Craig V. , Elliott Christopher S. 
Published: June 2019

AbstractAimsSacral neuromodulation (SNM) is a standard therapy for refractory overactive bladder (OAB). Traditionally, SNM placement involves placement of an S3 lead with 1–3 weeks of testing before considering a permanent implant. Given the potential risk of bacterial contamination during testing and high success rates published by some experts, we compared the costs of traditional 2‐stage against single‐stage SNM placement for OAB.MethodsWe performed a cost minimization analysis using published data on 2‐stage SNM success rates, SNM infection rates, and direct reimbursements from Medicare for 2017. We compared the costs associated with a 2‐stage vs single‐stage approach. We performed sensitivity analyses of the primary variables listed above to assess where threshold values occurred and used separate models for freestanding ambulatory surgery centers (ASC) and outpatient hospital departments (OHD).ResultsBased on published literature, our base case assumed a 69% SNM success rate, a 5% 2‐stage approach infection rate, a 1.7% single‐stage approach infection rate, and removal of 50% of non‐working single‐stage SNMs. In both ASC ($17 613 vs $18 194) and OHD ($19 832 vs $21 181) settings, single‐stage SNM placement was less costly than 2‐stage placement. The minimum SNM success rates to achieve savings with a single‐stage approach occur at 65.4% and 61.3% for ASC and OHD, respectively.ConclusionsUsing Medicare reimbursement, single‐stage SNM placement is likely to be less costly than 2‐stage placement for most practitioners. The savings are tied to SNM success rates and reimbursement rates, with reduced costs up to $5014 per case in centers of excellence (≥ 90% success).
Epithelioid sarcoma in children, adolescents, and young adults: Localized, primary metastatic and relapsed disease. Treatment results of five Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry
Authors: Sparber‐Sauer Monika , Koscielniak Ewa , Vokuhl Christian , Seitz Guido , Hallmen Erika , von Kalle Thekla , Scheer Monika , Münter Marc , Bielack Stefan S. , Ladenstein Ruth , Fuchs Joerg , Klingebiel Thomas ,   the CWS Study Group
Published: June 2019

AbstractBackgroundEpithelioid sarcoma (ES) is a rare malignant soft‐tissue tumor. Little is known about the optimal treatment of primary localized (LD), metastatic (MD), and relapsed disease (RD).MethodsCharacteristics, treatment, and outcome of 67 patients registered within the Cooperative Weichteilsarkom Studiengruppe CWS‐81, ‐86, ‐91, ‐96, ‐2002P trials and the registry SoTiSaR were analyzed (1981–2016).ResultsThe median age was 14 years (range, 0.7–26.9); 53 patients had localized disease (LD) and 14 metastatic disease (MD). A total of 58 of 67 patients were treated with primary resection. Resection was microscopically complete (R0) in 35, microscopically incomplete (R1) in 12, macroscopically incomplete (R2) in 20 patients. Radiotherapy (RT) was administered to 33 of 67 patients and 49 of 67 patients received chemotherapy (CHT). Complete remission (CR) was achieved in 45 of 53 (85%) patients with LD. Twenty‐seven of 53 patients relapsed after a median time of 0.9 years (range, 0.1–2.3). Relapse therapy consisted of resection (n = 19/27), RT (n = 10/27), CHT (n = 12/27), and limb perfusion (n = 3/27). The five‐year event‐free survival and overall survival of patients with LD, MD, and RD was 35% (± 12, CI 95%) and 58% (± 14, CI 95%), 7% (± 14, CI 95%), and 9% (± 16, CI 95%), 24% (± 17, CI 95%), and 40% (± 20, CI 95%), respectively. Tumor size, IRS group, tumor invasiveness, nodal status, and best resection correlated with a favorable prognosis in patients with LD while best resection was the only significant factor in patients with RD.ConclusionsComplete tumor resection correlates with long‐term survival in patients with ES.
Synergistic effect of nano‐SiO2 and small‐sized graphene oxide on carbon fiber/epoxy composite
Authors: Chu Caixia , Ge Heyi , Zhang Kaili , Gu Nianliang , Liu Shanshan , Jin Chaosheng 
Published: June 2019

AbstractThe poor interface of carbon fiber (CF) reinforced composites has long been one that researchers want to facilitate. A hierarchical structure of nano‐SiO2 and small‐sized graphene oxide (sGO) on CF was constructed by a layer‐by‐layer method. The electrochemically treated CF was evenly coated with sGO sheets as a medium layer, which made nano‐SiO2 uniformly spread over CF by electrostatic adsorption. The hierarchical structure could provide the synergistic reinforcement on the mechanical properties of CF composite by improving interface adhesion, mechanical interlocking, and chemical bonding. The interlaminar shear strength value of SiO2‐sGO‐CF/epoxy composite reached 71.1 MPa, which was increased by 33.45% compared with the electrochemical etching CF/epoxy composite. The results show that the sizing of sGO and nano‐SiO2 plays a positive synergistic effect by hierarchical reinforcement.
Investigation of Oligodendrocyte Precursor Cell Differentiation by Quantitative Proteomics
Authors: Schoor Carmen , Brocke‐Ahmadinejad Nahal , Gieselmann Volkmar , Winter Dominic 
Published: June 2019

AbstractOligodendrocytes, the myelinating cells of the central nervous system, are essential for correct brain function. They originate from oligodendrocyte precursor cells through a differentiation process which is only incompletely understood and impaired in a variety of demyelinating diseases. Better knowledge of this differentiation holds the promise to develop novel therapies for these disorders. The differentiation of rat oligodendrocyte precursor cells to oligodendrocytes in vitro is investigated. After confirmation of differentiation by immunohistochemical analysis using cell type‐specific marker proteins, a quantitative proteomics study using tandem mass tags (TMT) is conducted. Four time points of differentiation covering early, intermediate, and late stages are investigated. Data analysis by Mascot and MaxQuant identified 5259 protein groups of which 471 are not described in the context of cells of the oligodendroglial lineage before. Quantitative analysis of the dataset revealed distinct regulation patterns for proteins of different functional categories including metabolic processes, regulation of the cell cycle, and transcriptional control of protein expression. The present data confirm a significant number of proteins known to play a role in oligodendrocytes and myelination. Furthermore, novel candidate proteins are identified which may play an important role in this differentiation process providing a valuable resource for oligodendrocyte research.
DFT mechanistic study on tandem sequential [4 + 2]/[3 + 2] addition reaction of cyclooctatetraene with functionalized acetylenes and nitrile imines
Authors: Opoku Ernest , Tia Richard , Adei Evans 
Published: June 2019

AbstractThe mechanistic pathways for the tandem sequential [4 + 2] / [3 + 2] and [3 + 2]/[4 + 2] cycloaddition reaction of functionalized‐acetylenes with cyclooctatetraene (COTE) and nitrile imines for the formation of the biologically‐active tricyclic cyclobutane‐condensed pyrazoline systems, and the subsequent cycloreversion/thermolysis of these adducts, have been studied using density functional theory (DFT) at the M06‐2X/6‐31G(d) and 6‐311G(d,p) levels with the aim of providing mechanistic rationale for the regioselectivities and stereoselectivities. Along the [4 + 2] / [3 + 2] addition sequence, it has been found that the initial 6π‐electrocyclic ring‐closure of the COTE is the rate‐determining step irrespective of the type of substituent on the parent acetylene or the nitrile imine. The mechanistic channels along the [4 + 2] / [3 + 2] addition sequence show that the addition of the dipole across the unsubstituted olefinic bond in the cyclohexadiene moiety in the endo fashion is the most favored, which is in agreement with experimentally observed selectivity. The results show that the thermolysis proceeds with relatively high activation barriers toward formation of the monocyclic pyrazolines among other products. The decomposition of the tandem adducts has been found to be controlled solely by kinetic factors. An exploration of a [3 + 2] / [4 + 2] addition sequence as a mechanistic possibility reveals that in contrast to the [4 + 2] / [3 + 2] addition sequence, the Diels‐Alder addition step is the rate‐determining. The [3 + 2] / [4 + 2] addition order is found as an approach with better selectivity as it leads to formation of only tandem adducts where the nitrile imines are attached to the substituted olefinic bond in the cyclohexadiene subunit. The results show that the monocyclic pyrazolines obtained from the thermolysis of the [4 + 2] / [3 + 2] tandem adducts could easily be obtained from a direct 1,3‐dipolar addition of the alkynes with the dipoles which has been found to proceed rapidly with low activation barriers. The results are rationalized with perturbation molecular orbital theory.
Reliability of pain pressure threshold algometry in persons with conservatively managed wrist fractures
Authors: Sæbø Humaira , Naterstad Ingvill Fjell , Stausholm Martin Bjørn , Bjordal Jan Magnus , Joensen Jon 
Published: June 2019

AbstractObjectiveWrist fracture is a common injury in Norway. Pressure algometry is widely used to quantify patients' pain threshold in various anatomical locations. The aim of this study was to explore the reliability of pain pressure threshold (PPT) algometry in persons with conservatively managed distal radius fractures.MethodsIn this cross‐sectional study, three raters (A, B, and C) tested the PPT of participants (18–97 years of age) with a unilateral distal radius fracture after removal of the cast. The raters conducted two measurements of both wrists. Intrarater reliability was examined in 75, 50, and 25 participants by Raters A, B, and C, respectively. Interrater reliability was tested in 50 and 25 participants by Rater Pairs A–B and A–C, respectively. Relative reliability was calculated with intraclass correlation coefficient (ICC1.1) and absolute reliability using within‐subject standard deviation (Sw).ResultsThere was a significant difference in the PPT between the participants' injured and noninjured wrists (p < .0001). The mean PPT was 29% lower in the injured than in the noninjured wrists, 175 kPa (SD ± 62) versus 248 kPa (SD ± 83). Intrarater reliability (A) of PPT algometry was better in injured wrists than in noninjured wrists (ICC1.1 = 0.825 vs. 0.765 and Sw = 27 vs. 43 kPa). Similarly, interrater reliability of PPT algometry was better in injured wrists than in noninjured wrists. In injured wrists, the interrater reliability of PPT algometry between Raters A and B was 0.617 (ICC1.1) and Sw was 51 kPa, and between Raters A and C, the interrater reliability was 0.706 (ICC1.1) and Sw was 48 kPa.ConclusionPPT algometry is a useful measurement tool with acceptable reliability and thus suitable for monitoring and quantifying pain in persons with conservatively managed wrist fractures. To be more certain that a change has occurred, the same rater should perform the measurements.
Development of a Parsimonious Design for Optimal Classification of Exclusive Breastfeeding
Authors: Liu Zheng , Diana Aly , Slater Christine , Preston Thomas , Gibson Rosalind S. , Houghton Lisa , Duffull Stephen B. 
Published: June 2019

A deuterium oxide dose‐to‐mother (DTM) technique is used to determine if an infant is exclusive breastfeeding (EBF). However, the DTM method is intensive, requiring seven paired mother–infant samples during a 14‐day study period. The purpose of this study was to develop a field‐friendly protocol. Data from 790 mother–infant pairs from nine countries were analyzed using a Markov chain Monte Carlo method with Stan. The data were split into (i) model building (565 pairs) and (ii) design evaluation (225 pairs). EBF classification was based on a previously published cut‐off for nonmilk water intake. Classification based on the full design was the reference (gold standard classification). The receiver operating characteristics of parsimonious designs were used to determine an optimal parsimonious classification method. The best two postdose windows (days 7–9 and 13–14) yielded optimal categorization with similar performance in the design evaluation data. This postdose two‐sample design provided 95% sensitivity and specificity when compared with the full design.
Modeling group and individual learning: lessons for integrating disciplines and agile research
Authors: Anderson Edward G. , Lewis Kyle 
Published: June 2019

AbstractWe discuss the genesis of the paper for which the 2018 Forrester Award has been given. We then summarize its findings and put it into the context of the research streams in which it is embedded. We also describe the effects of the award paper on subsequent research. We then briefly discuss how laboratory experiment, field, and modeling work can complement each other in social systems research. Finally, we present some thoughts for leveraging the expertise of researchers and audiences from outside domains to the field of system dynamics, based on lessons from our work together as co‐authors and our mutual experience in project management, particularly in agile software development techniques.© 2019 System Dynamics Society