bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abrupt drainage basin reorganization following a Pleistocene river capture
Authors: Fan Niannian , Chu Zhongxin , Jiang Luguang , Hassan Marwan A. , Lamb Michael P. , Liu Xingnian 
Published: September 2018

AbstractRiver capture is a dramatic natural process of internal competition through which mountainous landscapes evolve and respond to perturbations in tectonics and climate. River capture may occur when one river network grows at the expense of another, resulting in a victor that steals the neighboring headwaters. While river capture occurs regularly in numerical models, field observations are rare. Here we document a late Pleistocene river capture in the Yimeng Mountains, China that abruptly shifted 25 km2of drainage area from one catchment to another. River terraces and imbricated cobbles indicate that the main channel incised 27 m into granitic bedrock within 80 kyr, following the capture event, and upstream propagating knickpoints and waterfalls reversed the flow direction of a major river. Topographic analysis shows that the capture shifted the river basins far from topographic equilibrium, and active divide migration is propagating the effects of the capture throughout the landscape.
Quantum dot single-photon sources with ultra-low multi-photon probability
Authors: Hanschke Lukas , Fischer Kevin A. , Appel Stefan , Lukin Daniil , Wierzbowski Jakob , Sun Shuo , Trivedi Rahul , Vučković Jelena , Finley Jonathan J. , Müller Kai 
Published: September 2018

AbstractHigh-quality sources of single photons are of paramount importance for quantum communication, sensing, and metrology. To these ends, resonantly excited two-level systems based on self-assembled quantum dots have recently generated widespread interest. Nevertheless, we have recently shown that for resonantly excited two-level systems, emission of a photon during the presence of the excitation laser pulse and subsequent re-excitation results in a degradation of the obtainable single-photon purity. Here, we demonstrate that generating single photons from self-assembled quantum dots with a scheme based on two-photon excitation of the biexciton strongly suppresses the re-excitation. Specifically, the pulse-length dependence of the multi-photon error rate reveals a quadratic dependence in contrast to the linear dependence of resonantly excited two-level systems, improving the obtainable multi-photon error rate by several orders of magnitude for short pulses. We support our experiments with a new theoretical framework and simulation methodology to understand few-photon sources.
Combining in silico and in vitro experiments to characterize the role of fascicle twist in the Achilles tendon
Authors: Shim Vickie B. , Handsfield Geoff G. , Fernandez Justin W. , Lloyd David G. , Besier Thor F. 
Published: September 2018

AbstractThe Achilles tendon (AT), the largest tendon in the human body has a unique structural feature, that is the fascicles in the AT display spiral twist. However, their functional and structural roles are still unclear. We used subject-specific computational models and tissue mechanical experiment to quantitatively characterize the role of fascicle twist in the Achilles tendon. Ten subject-specific finite element (FE) models of the Achilles tendon were developed from ultrasound images. Fascicle twist was implemented in these models using the material coordinate system available in our FE framework. Five different angles (0~60°) were implemented and material property optimization was performed for each of them (total 50 sets) using results from uniaxial stretch experiment. We showed that fascicle twist allows for even distribution of stress across the whole tendon, thus improving tissue strength. The predicted rupture load increased up to 40%. A number of connective tissues display similar fascicle twists in their structure. The resulting non-uniform strain distribution has been hypothesized as a primary factor in tissue degeneration and injuries. Therefore, our technique will be used to design biomechanically informed training and rehabilitation protocols for management of connective tissue injuries and degeneration.
Major Depression Impairs the Use of Reward Values for Decision-Making
Authors: Rupprechter Samuel , Stankevicius Aistis , Huys Quentin J. M. , Steele J. Douglas , Seriès Peggy 
Published: September 2018

AbstractDepression is a debilitating condition with a high prevalence. Depressed patients have been shown to be diminished in their ability to integrate their reinforcement history to adjust future behaviour during instrumental reward learning tasks. Here, we tested whether such impairments could also be observed in a Pavlovian conditioning task. We recruited and analysed 32 subjects, 15 with depression and 17 healthy controls, to study behavioural group differences in learning and decision-making. Participants had to estimate the probability of some fractal stimuli to be associated with a binary reward, based on a few passive observations. They then had to make a choice between one of the observed fractals and another target for which the reward probability was explicitly given. Computational modelling was used to succinctly describe participants’ behaviour. Patients performed worse than controls at the task. Computational modelling revealed that this was caused by behavioural impairments during both learning and decision phases. Depressed subjects showed lower memory of observed rewards and had an impaired ability to use internal value estimations to guide decision-making in our task.
Ear transplantations reveal conservation of inner ear afferent pathfinding cues
Authors: Elliott Karen L. , Fritzsch Bernd 
Published: September 2018

AbstractVertebrate inner ear neurons project into the correct brainstem nuclei region before target neurons become postmitotic, or even in their absence. Moreover, afferents from transplanted ears in frogs have been shown to navigate to vestibular nuclei, suggesting that ear afferents use molecular cues to find their target. We performed heterochronic, xenoplastic, and heterotopic transplantations in chickens to investigate whether inner ear afferents are guided by conserved guidance molecules. We show that inner ear afferents can navigate to the vestibular nuclei following a delay in afferent entry and when the ear was from a different species, the mouse. These data suggest that guidance molecules are expressed for some time and are conserved across amniotes. In addition, we show that chicken ears transplanted adjacent to the spinal cord project dorsally like in the hindbrain. These results suggest that inner ear afferents navigate to the correct dorsoventral brainstem column using conserved cues.
Genetic diversity and phylogeny of South African Meloidogyne populations using genotyping by sequencing
Authors: Rashidifard Milad , Fourie Hendrika , Véronneau Pierre-Yves , Marais Mariette , Daneel Mieke Stefanie , Mimee Benjamin 
Published: September 2018

AbstractMeloidogyne species cause great crop losses worldwide. Although genetic host plant resistance is an effective control strategy to minimize damage caused by Meloidogyne, some resistant genes are ineffective against virulent species such as Meloidogyne enterolobii. Detailed knowledge about the genetic composition of Meloidogyne species is thus essential. This study focused on genotyping-by-sequencing (GBS) and Pool-Seq to elucidate the genetic relation between South African M. enterolobii, M. incognita and M. javanica populations. Hence, 653 common single nucleotide polymorphisms (SNPs) were identified and used to compare these species at genetic level. Allele frequencies of 34 SNPs consistently differed between the three Meloidogyne species studied. Principal component and phylogenetic analyses grouped the M. enterolobii populations in one clade, showing a distant relation to the M. javanica populations. These two species also shared genetic links with the M. incognita populations studied. GBS has been used successfully in this study to identify SNPs that discriminated among the three Meloidogyne species investigated. Alleles, only occurring in the genome of M. enterolobii and located in genes involved in virulence in other animal species (e.g. a serine/threonine phosphatase and zinc finger) have also been identified, accentuating the value of GBS in future studies of this nature.
Rapid Adaptation to the Timbre of Natural Sounds
Authors: Piazza Elise A. , Theunissen Frédéric E. , Wessel David , Whitney David 
Published: September 2018

AbstractTimbre, the unique quality of a sound that points to its source, allows us to quickly identify a loved one’s voice in a crowd and distinguish a buzzy, bright trumpet from a warm cello. Despite its importance for perceiving the richness of auditory objects, timbre is a relatively poorly understood feature of sounds. Here we demonstrate for the first time that listeners adapt to the timbre of a wide variety of natural sounds. For each of several sound classes, participants were repeatedly exposed to two sounds (e.g., clarinet and oboe, male and female voice) that formed the endpoints of a morphed continuum. Adaptation to timbre resulted in consistent perceptual aftereffects, such that hearing sound A significantly altered perception of a neutral morph between A and B, making it sound more like B. Furthermore, these aftereffects were robust to moderate pitch changes, suggesting that adaptation to timbral features used for object identification drives these effects, analogous to face adaptation in vision.
Superconducting Phases in Lithium Decorated Graphene LiC6
Authors: Gholami Rouhollah , Moradian Rostam , Moradian Sina , Pickett Warren E. 
Published: September 2018

AbstractA study of possible superconducting phases of graphene has been constructed in detail. A realistic tight binding model, fit to ab initio calculations, accounts for the Li-decoration of graphene with broken lattice symmetry, and includes s and d symmetry Bloch character that influences the gap symmetries that can arise. The resulting seven hybridized Li-C orbitals that support nine possible bond pairing amplitudes. The gap equation is solved for all possible gap symmetries. One band is weakly dispersive near the Fermi energy along Γ → M where its Bloch wave function has linear combination of $${d}_{{x}^{2}-{y}^{2}}$$

d

x

2

−

y

2

and dxy character, and is responsible for $${d}_{{x}^{2}-{y}^{2}}$$

d

x

2

−

y

2

and dxy pairing with lowest pairing energy in our model. These symmetries almost preserve properties from a two band model of pristine graphene. Another part of this band, along K → Γ, is nearly degenerate with upper s band that favors extended s wave pairing which is not found in two band model. Upon electron doping to a critical chemical potential μ1 = 0.22 eV the pairing potential decreases, then increases until a second critical value μ2 = 1.3 eV at which a phase transition to a distorted s-wave occurs. The distortion of d- or s-wave phases are a consequence of decoration which is not appear in two band pristine model. In the pristine graphene these phases convert to usual d-wave or extended s-wave pairing.
Assessment of the impacts of climatic variability and anthropogenic stress on hydrologic resilience to warming shifts in Peninsular India
Authors: Sinha Jhilam , Sharma Ashutosh , Khan Manas , Goyal Manish Kumar 
Published: September 2018

AbstractMost parts of the world are witnessing climatic warming and the trend is expected to increase in the future. It is important to assess the response of watershed hydrology to this warming. Moreover, human interactions and climatic variability influence the water balance of a catchment. We perform contribution analysis along with resilience study using Budyko framework and two parameters (dynamic deviation and modified elasticity), in-order to comprehend the involvement of anthropogenic stress and climatic variance on partitioning of precipitation and their relation with hydrologic resilience to warming shifts across 55 catchments in peninsular India. Here, 23 catchments have displayed hydrologic resilience (low departure and high elasticity) to climatic warming shifts. Only 37.14% of anthropogenic dominated catchments (higher contribution from human activities in runoff changes) were found to be resilient whereas 58.82% of climate dominated catchments had resilience attributes. Most of the catchments on western and extreme southern part of India were not hydrologic resilient. Extensive human interactions tend to depart the catchment from expected hydrological functioning under critical climatic conditions (Warming in our study) that lead to declining of hydrological resilience.
Plant growth-promoting rhizobacteria promote plant size inequality
Authors: Gange Alan C. , Gadhave Kiran R. 
Published: September 2018

AbstractThe uniformity of crop yield is extremely important for consumers and of as much relevance to the grower as overall yield. However, size inequality within a plant population is rarely measured and has never before been considered in relation to the use of beneficial microbes for yield enhancement. For the first time, we show that addition of soil bacteria to calabrese plants significantly increased size inequality. These effects were usually more apparent in above-ground biomass. This was caused by some (but not all) plants growing very large when inoculated with bacteria, while control plants were mostly small. We suggest that the main reason is the incompatibility of the inoculated bacteria with those already present in the rhizosphere. In some cases the inoculum matched the indigenous community, providing a benefit to plant growth, while often it did not and plants remained relatively small. We conclude that analyses of size inequality should be an integral part of experiments using microbial soil amendments. These analyses can help to inform the production of more effective microbial products and to ensure that the integration of beneficial microbes into sustainable production systems does not impair uniformity in yield.
Preparation of quantum information encoded on three-photon decoherence-free states via cross-Kerr nonlinearities
Authors: Heo Jino , Kang Min-Sung , Hong Chang Ho , Hong Jong-Phil , Choi Seong-Gon 
Published: September 2018

AbstractWe present a scheme to encode quantum information (single logical qubit information) into three-photon decoherence-free states, which can conserve quantum information from collective decoherence, via nonlinearly optical gates (using cross-Kerr nonlinearities: XKNLs) and linearly optical devices. For the preparation of the decoherence-free state, the nonlinearly optical gates (multi-photon gates) consist of weak XKNLs, quantum bus (qubus) beams, and photon-number-resolving (PNR) measurement. Then, by using a linearly optical device, quantum information can be encoded on three-photon decoherence-free state prepared. Subsequently, by our analysis, we show that the nonlinearly optical gates using XKNLs, qubus beams, and PNR measurement are robust against the decoherence effect (photon loss and dephasing) in optical fibers. Consequently, our scheme can be experimentally implemented to efficiently generate three-photon decoherence-free state encoded quantum information, in practice.
Deregulation of Notch1 pathway and circulating endothelial progenitor cell (EPC) number in patients with bicuspid aortic valve with and without ascending aorta aneurysm
Authors: Balistreri Carmela R. , Crapanzano Floriana , Schirone Leonardo , Allegra Alberto , Pisano Calogera , Ruvolo Giovanni , Forte Maurizio , Greco Ernesto , Cavarretta Elena , Marullo Antonino G. M. , Sciarretta Sebastiano , Frati Giacomo 
Published: September 2018

AbstractBicuspid aortic valve (BAV) is frequently associated with the development of ascending aortic aneurysm, even if the underlying mechanisms remain to be clarified. Here, we investigated if a deregulation of Notch1 signaling pathway and endothelial progenitor cells (EPCs) number is associated with BAV disease and an early ascending aortic aneurysm (AAA) onset. For this purpose, 70 subjects with BAV (M/F 50/20; mean age: 58.8 ± 14.8 years) and 70 subjects with tricuspid aortic valve (TAV) (M/F 35/35; mean age: 69.1 ± 12.8 years) and AAA complicated or not, were included. Interestingly, patients with AAA showed a significant increase in circulating Notch1 levels and EPC number than subjects without AAA. However, circulating Notch1 levels and EPC number were significantly lower in BAV subjects than TAV patients either in the presence or absence of AAA. Finally, Notch pathway was activated to a greater extent in aortic aneurysmatic portions with respect to healthy aortic fragments in both BAV and TAV patients. However, the expression of genes encoding components and ligands of Notch pathway in aortic tissues was significantly lower in BAV than TAV subjects. Our study demonstrates that BAV subjects are characterized by a significant decrease in both tissue and circulating levels of Notch pathway, and in blood EPC number than TAV patients, either in presence or absence of AAA disease.
Pas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver
Authors: Dongil P. , Pérez-García A. , Hurtado-Carneiro V. , Herrero-de-Dios C. , Blazquez E. , Alvarez E. , Sanz C. 
Published: September 2018

AbstractMetabolic dysfunction in the liver is the cause of numerous pathologies, which are associated with an altered redox state. PASK (PAS Domain Kinase) is a nutrient and bioenergetic sensor. We contend that PASK could act as an oxidative stress sensor in liver and/or control the metabolic balance, playing a role in the mitochondrial homeostasis. Using PASK-deficient mice, we observed that PASK deficiency promotes antioxidant response mechanisms: a lower production of ROS/RNS under non-fasting conditions, overexpression of genes coding to ROS-detoxifying enzymes and mitochondrial fusion proteins (MnSod Gpx, Mfn1 and Opa1), coactivator Ppargc1a, transcription factors (Pparg and FoxO3a) and deacetylase Sirt1. Also, under fasting conditions, PASK deficiency induced the overexpression of Ppargc1a, Ppara, Pparg, FoxO3a and Nrf2 leading to the overexpression of genes coding to antioxidant enzymes such as MnSOD, Cu/ZnSOD, GPx, HO1 and GCLm. Additionally, inducing PINK1 involved in cell survival and mitophagy. These changes kept ROS steady levels and improved the regenerative state. We suggest a new role for PASK as a controller of oxidative stress and mitochondrial dynamics in the liver. In fact, antioxidant response is PASK dependent. PASK-targeting could therefore be a good way of reducing the oxidative stress in order to prevent or treat liver diseases.
Kartogenin inhibits pain behavior, chondrocyte inflammation, and attenuates osteoarthritis progression in mice through induction of IL-10
Authors: Kwon Ji Ye , Lee Seung Hoon , Na Hyun-Sik , Jung KyungAh , Choi JeongWon , Cho Keun Hyung , Lee Chang-Yong , Kim Seok Jung , Park Sung-Hwan , Shin Dong-Yun , Cho Mi-La 
Published: September 2018

AbstractOsteoarthritis (OA) is a major degenerative joint condition that causes articular cartilage destruction. It was recently found that enhancement of chondroclasts and suppression in Treg cell differentiation are involved in the pathogenesis of OA. Kartogenin (KGN) is a small drug-like molecule that induces chondrogenesis in mesenchymal stem cells (MSCs). This study aimed to identify whether KGN can enhance severe pain behavior and improve cartilage repair in OA rat model. Induction of OA model was loaded by IA-injection of MIA. In the OA rat model, treatment an intra-articular injection of KGN. Pain levels were evaluated by analyzing PWL and PWT response in animals. Histological analysis and micro-CT images of femurs were used to analyze cartilage destruction. Gene expression was measured by real-time PCR. Immunohistochemistry was analyzed to detect protein expression. KGN injection significantly decreased pain severity and joint destruction in the MIA-induced OA model. KGN also increased mRNA levels of the anti-inflammatory cytokine IL-10 in OA patients’ chondrocytes stimulated by IL-1β. Decreased chondroclast expression, and increased Treg cell expression. KGN revealed therapeutic activity with the potential to reduce pain and improve cartilage destruction. Thus, KGN could be a therapeutic molecule for OA that inhibits cartilage damage.
Skeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves
Authors: Yu Kuai , Matzapetakis Manolis , Valent Daniel , Saco Yolanda , De Almeida André M. , Terré Marta , Bassols Anna 
Published: September 2018

AbstractThe effects of different amino acid (AA) supplementations of milk protein-based milk replacers in pre-ruminant calves from 3 days to 7 weeks of age were studied. Animals were divided into 4 groups: Ctrl) Control group fed with milk protein-based milk replacer without supplementation; GP) supplementation with 0.1% glycine and 0.3% proline; FY) supplementation with 0.2% phenylalanine and 0.2% tyrosine; MKT) supplementation with 0.62% lysine, 0.22% methionine and 0.61% threonine. For statistical analysis, t-test was used to compare AA-supplemented animals to the Ctrl group. At week 7, body weight and average daily gain (ADG) were measured and blood samples and skeletal muscle biopsies were taken. Blood biochemistry analytes related to energy metabolism were determined and it was shown that MKT group had higher serum creatinine and higher plasma concentration of three supplemented AAs as well as arginine compared with the Ctrl group. GP group had similar glycine/proline plasma concentration compared with the other groups while in FY group only plasma phenylalanine concentration was higher compared with Control. Although the AA supplementations in the GP and FY groups did not affect average daily gain and metabolic health profile from serum, the metabolome analysis from skeletal muscle biopsy revealed several differences between the GP-FY groups and the Ctrl-MKT groups, suggesting a metabolic adaptation especially in GP and FY groups.
Diminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients
Authors: Li Xiu , Chen Haijun , Lv Yue , Chao Herta H. , Gong Liang , Li Chiang-Shan R. , Cheng Huaidong 
Published: September 2018

AbstractTo investigate chemotherapy dosage-related cognitive impairment and its neural mechanisms in breast cancer (BC) patients. Twenty-eight breast cancer patients after each chemotherapy cycle and matched 29 healthy control subjects underwent structural magnetic resonance imaging. Voxel-based morphometry analysis was performed to compare group differences in the gray matter for the whole brain. Furthermore, mediation analysis was conducted to explore the role of brain structures in chemotherapy dosage-related cognitive impairment. Voxel-based morphometry analysis was performed in gray matter for the whole brain of BC patients after chemotherapy. The results revealed that the gray matter density in the left inferior frontal gyrus, right middle frontal gyrus, right fusiform area, and bilateral cerebellum was decreased in the BC patients compared to controls. The number of chemotherapy cycles was negatively associated with general cognitive capacity, verbal fluency and digit span performance in the BC patients. In addition, decreased gray matter density in the right middle frontal gyrus could mediate the chemotherapy dosage effects on verbal fluency performance. These findings indicate that the dose-response relationship between chemotherapy and cognitive impairment may depend on the decreases in gray matter density of the frontal cortical structures.