bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE MODERN VIEWS TO DIAGNOSIS OF KIDNEY DAMAGE IN PATIENTS WITH ARTERIAL HYPERTENSION FOR EARLY PREVENTION
Authors: Khimion L. , Timoshchuk L. 
Published: June 2018

The article discusses in detail the problem of the medico-social significance of early kidney damage in essential hypertension (EH) (according to the literature review and own research).
Aim. To determine the prevalence of subclinical renal damage in the EAG of the first stage and to assess the diagnostic significance of the functional renal reserve (FRR).
Materials and methods. A total of 70 patients were examined. The control group consisted of 50 people with established diagnosis of EH I stage, women - 20 (40%), mean age – 44,6±1,78 years, men - 30 (60%), average age – 46,57±2,23 years. The average duration of the EH is 3,5 ± 0,5 years. The control group included 20 practically healthy persons (11 women (55%), men - 9 (45%), average age 41,1 ± 1,96 years). All the patients underwent the following examinations: clinical examination, general clinical blood and urine tests, biochemical blood test (total protein, urea, creatinine, glucose, lipidogram) 24-hour BP monitoring, ECG, ECHO-CG, carotid ultrasound, definition FRR. The body mass index (BMI), the glomeru-laorpfhiltthratlimonosrcaotpey(aGnFdR) was calculated.
Results. According to the FRR, the functional state of the kidneys significantly differs between subgroups of patients with EH stage I (p <0.05). In patients with the control group FRR - 62.14±10.60%, compared with patients with EH of the 1st subgroup – 23,31±4,9% and the 2nd subgroup - 10±3,02%. In patients of the 2nd subgroup of FRR, although within normal limits, it is noteworthy that it is located on the lower border. When performing the correlation analysis of the data of FRR and BP, the dependence was inversely proportional (r = -0.7, p <0.05).
Conclusion. The eGFR was determined by the CKD-EPI formula in the examined patients with EH and control groups, which does not differ significantly.
FRR in patients with EH I-II grade with the duration of the disease up to 5 years is significantly lower than in practically healthy peers; p <0.05.
In patients with EH II grade (2nd subgroup) FNR more than twice as low as patients with EAG I degree; and is 10±3,2% and 23,3±4,9% respectively; p <0.05.
Thus, according to the results of the study, it was found that FRR is a more sensitive indicator, which can help in the early diagnosis of kidney damage with EH.
THE EFFECTIVENESS OF THE IMPLEMENTATION OF PROTOCOLS NEPHROLOGY MEDICAL CARE TO CHILDREN AT REGIONAL LEVEL
Authors: Bezruk V. V. , Andriychuk T. P. , Bezruk Т. О. , Pervozvanska O. I. 
Published: June 2018

The incidence of kidney disease and urinary tract are important indicators of the health status of the child population.
The objective. Analysis of the effectiveness of the implementation of protocols Nephrology medical care to children in region.
Materials and methods. The material for this study is reporting documentation about the condition of the nephrological service care for children’s population of the Chernivtsi region in 2013-2016 and the data of The Center of medical statistics of Ministry of Health of Ukraine.
Results and discussion. Analyzes the main indicators of child nephrology service in Chernivtsi region. The introduction of local protocols and clinical trials of patients with nephrological diseases in medical institutions of Chernivtsi region, and further - the general agreed local protocols and clinical routes of patients, positively influenced the quality of nephrological care in the region.
Conclusion. The introduction of general agreed local protocols and clinical trails pediatric patients Nephrology pathology in medical institutions of Chernivtsi region have improved the quality of care at all stages, respecting the standards for the provision of specialized medical care.
PERITONEAL DIALYSIS TECHNIQUE SURVIVAL: A SINGLE-CENTER EXPERIENCE ANALYSIS OF THE PERITONEAL DIALYSIS TREATMENT IN A SINGLE CENTER
Authors: Burdeyna O. , Stepanova N. , Kolesnyk M. 
Published: June 2018

The aim of the study was to evaluate retrospectively the survival of the peritoneal dialysis (PD) technique survival and identify the factors that affect it.
Patients and methods. A total of 38 patients with end-stage renal disease treated with PD from 2005 to May 2017 have been included in retrospective, study (average age 49.6 ± 5.6). Data were collected from medical records.
Results. The average survival rate of the PD method in our center was 53.3 ± 7.4 months, and in patients with nondiabetic kidney disease it was significantly higher. During the follow-up only 11/38 (28.9 %) patients continue treatment of PD, 12/38 (31.6 %) were changed to HD, 4/38 (10.6 %) patients kidney transplantation was performed and 11/38 %) died. The main reason of the letal cases was cardiovascular complications (36.6 %). The patient mortality was significantly depended on the diuresis volume and the level of GFR at the time of PD initiation.
Conclusions. PD technique survival in our center correlate with the results of the PD treatment patients worldwide.
DYSLIPIDEMIA AS A FACTOR FOR PROGRESSION OF RENAL OSTEODYSTROPHY AND CORONARY HEART DISEASE IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON PERITONEAL DIALYSIS
Authors: Lesovoy V. , Andonieva N. , Huts E. , Dubovik M. , Grushka M. 
Published: June 2018

Numerous studies of the last years focused on various links of pathogenesis and factors for progression of coronary heart disease (CHD) and chronic kidney disease (CKD) allowed to find intersection, such as progression of atherosclerosis or phosphorus and calcium and lipid imbalance, which lead to vascular calcareous infiltration, development of renal osteodystrophy and rising of cardiac risks.
Purpose of the research: To define indicators of lipid exchange in patients on peritoneal dialysis which can be factors for progression of renal osteodystrophy and ischemic heart disease.
Materials and methods. Indicators of lipid exchange, various types of renal osteodystrophy and clinical types of ischemic heart disease in 114 patients receiving peritoneal dialysis therapy in the Regional Clinical Center of Urology and Nephrology of V.I.Shapoval were analysed.
Results. Having analysed changes in blood lipid profile of patients on peritoneal dialysis (PD), we found out a reliable growth of high-density lipoproteins (HDL) in a group of patients without signs of ischemic heart disease and in a group of patients having stable angina, whose primary types of renal osteodystrophy were osteoporosis and fibrous ostitis. Reliable differences had also very-low-density lipoproteins (VLDL) which also were the highest in a group of patients having stable angina without signs of cardiac decompensation. The average duration of PD treatment of patients of this group was 12,3 months.
Conclusion. The results of the research confirmed that calcareous infiltration of vessels and heart valves on early stages of PD therapy is mainly caused by dyslipidemia and atherosclerotic changes and less by phosphorus and calcium imbalance which importance increases with duration of PD treatment.
MODERN VISION OF DEVELOPMENT FACTORS OF PROTEIN-ENERGY MALNUTRITION SYNDROME IN PATIENTS, RECEIVING PERITONEAL DIALYSIS
Authors: Lesovoy V. , Andonieva N. , Dubovik M. , Huts E. , Grushka M. 
Published: June 2018

Patients who have end-stage chronic kidney disease (СKD) and who receive substitutive peritoneal dialysis (PD) therapy, often have complication such as protein-energy malnutrition syndrome (PEMS). Important prognostic value is given to nutritional disorders as they increase prior disease development, complicate its correction, influence survival rate of patients of this category.
Purpose: to explore prevalence of protein-energy malnutrition syndrome in PD patients and define factors of its development.
Materials and methods: 67 PD patients were examined. Evaluation of nutritional status in patients under investigation was made using development of complex methodology that includes 5 specifications – body mass index (BMI), triceps skinfold, arm circumference – biceps, floating albumin and seraalbumin, absolute number of lymphocyte.
Results. PEMS was found in 35,8% of patients, 29,8% had mild case and 6% had moderate case with mixed form domination. 26,8% of PD patients had average high or high transport characteristics of abdominal membrane that provided increased protein loss through abdominal membrane on PD. It was determined that with the growth of С-reactive protein (CRP) level nutritional disorders increased. In our research chronic inflammation syndrome was found in 16,3% of cases. Besides, protein loss was growing fast after another dialysis peritonitis. Expressed deficit of daily consumption of protein was registered in 29,2% of patients.
Conclusion. Our researches analysis allowed us to define that risk factors of formation of protein metabolism disorders in PD patients are low protein consumption, connection with nutritional deficiency syndrome, system inflammatory reaction, protein loss with dialysis fluid having high transport characteristics of abdominal membrane and repeated dialysis peritonitis.
INFLUENCE OF SECONDARY HYPERPARATHYROIDISM ON THE CALCIFICATION OF HEART VALVES IN PATIENTS WITH CHRONIC KIDNEY DISEASE VD STAGE
Authors: Lesovoy V. , Andonieva N. , Valkovskaya T. 
Published: June 2018

The aim of this work was to study the relationship of elevated levels of parathyroid hormone (PTH) with cardiovascular changes (calcification of the heart valves) and to identify possible risk factors of calcification in the group of patients receiving renal replacement therapy.
Materials and methods. The study included 96 patients with ESRD: 1-st group receives the treatment of peritoneal dialysis (PD) (45 patients), 2-nd group haemodialysis (HD) (51 patients). In serum determined concentration of calcium, phosphorus, PTH. All patients underwent echocardiographic examination.
Results. The prevalence of secondary hyperparathyroidism in PD-patients reached 72%, in HD-patients 83%. Calcification of heart valves in both groups occurred in patients with high PTH level (greater than 400 PG/ml). Patients in both groups were significantly more frequent in the combined mitrale-aortic calcification. Isolated mitral calcification was detected more often aortic. Predictors of progression of calcification of heart valves in patients on PD is the age, in patients on HD - level average BP and the duration of dialysis therapy.
Conclusions. Echocardiological data and clinical and laboratory examination of patients with ESRD allowed us to estimate the prevalence and structure of mitrale-aortic calcification and its relationship with secondary hyperparathyroidism.
LEVEL ESTIMATION OF BLOOD SATURATION AT PATIENTS WITH CHRONIC KIDNEY DISEASE ON THE PROGRAM HEMODIALYSIS
Authors: Lysyanska О. U. 
Published: June 2018

Patients with chronic kidney disease, who are on outpatient program of hemodialysis treatment, have a risk of development of intradialysis chronic hypoxemia (hypoxemia, that appears during the hemodialysis), that appears during the program dialysis treatment.
Aim: identifying of patients with Chronic kidney disease with decrease of the percentage oxyhemoglobin content in arterial blood during hemodialysis.
Materials and Methods. Participated 91 patients with Chronic kidney disease on the program hemodialysis, who were monitored under the non-invasive method of pulsoximetry of blood saturation.
Results. During the research was found that the first group of patients with initial normal medical parameters (SpO2 within the normal range 95-99%) consisted 57 patients (62,6% from the general quantity); to the second group (SpO2 within 90-94%) (including,16 patients, medical parameters of whom were changed with time) belonged 21 patients (23,1%); to the third group (SpO2 range less than 90%) belonged 14 patients (15,4%) (13 of whom came to third group from second and one person got into this group with the previously normal medical parameters).
Conclusion. Part of the patients on program hemodialysis may occur the blood saturation fluctuation, with exposure of hypoxemia conditions, that may worsen the prognosis and increase the complication of the disease.
Movement and islands: a key issue in Generative Grammar
Authors: Augusto Marina Rosa Ana 
Published: June 2018

<p>This paper provides a brief overview of the main proposals, adopted in the generative framework, for island constraints. Starting from Ross (1967) through minimalist accounts, it addresses the most relevant concepts related to islands, emphasizing the search for a theoretical account for the phenomenon, but also stressing the challenges this kind of data poses for formal approaches. Some alternative accounts to islands, particularly processing considerations, are also brieﬂy commented upon. The article concludes highlighting some compatibilities between both approaches and stressing the relevance of a syntactic treatment to islands.</p><p>---------------------------------------------------------------------------------</p><p>Este artigo apresenta um panorama condensado das principais propostas, adotadas no quadro gerativista, para o fenômeno das ilhas sintáticas. Partindo de Ross (1967) até estudos conduzidos na abordagem minimalista, o estudo apresenta os principais conceitos relacionados ao fenômeno, enfatizando a busca por uma proposta teoricamente embasada, ao mesmo tempo em que desafios se colocam para a abordagem formal a partir desse tipo de dado. Algumas abordagens alternativas, particularmente considerações de processamento, são também apresentadas. Defende-se que embora haja compatibilidades entre as abordagens formal e de processamento, um tratamento sintático das restrições de ilhas é desejável.</p><p> </p>
SATELLITE DATA FOR INVESTIGATION OF RECENT STATE AND PROCESSES IN THE SIVASH BAY
Authors: Shchurova Ekaterina , Shchurova Ekaterina , Stanichnaya Rimma , Stanichnaya Rimma , Stanichny Sergey , Stanichny Sergey 
Published: June 2018

Sivash bay is the shallow-water lagoon of the Azov Sea. Restricted water exchange and high evaporation form Sivash as the basin with very high salinity. This factor leads to different from the Azov Sea thermal and ice regimes of Sivash. Maine aim of the study presented to investigate recent state and changes of the characteristics and processes in the basin using satellite data. Landsat scanners TM, ETM+, OLI, TIRS together with MODIS and AVHRR were used. Additionally NOMADS NOAA and MERRA meteorological data were analyzed. The next topics are discussed in the work: 1.	Changes of the sea surface temperature, ice regime and relation with salinity. 2.	Coastal line transformation – long term and seasonal, wind impact. 3.	Manifestation of the Azov waters intrusions through the Arabat spit, preferable wind conditions.
AML Subtype M5 Linked to Pulmonary Leukemic Infiltrates and Respiratory Failure and the Importance of Early Induction Chemotherapy
Authors: Chu Yvonne 
Published: June 2018

Currently there are no practice guidelines for evaluating lung infiltrates in patients with newly diagnosed acute myeloid leukemia (AML). More specifically, it remains unclear if there is a need to obtain a lung tissue biopsy prior to the initiation of induction chemotherapy. This clinical question is particularly important in instances in which obtaining a lung tissue diagnosis can potentially delay anti-leukemic treatment. Here we describe a case of such lung infiltrates in which a newly diagnosed AML patient underwent a diagnostic lung biopsy before receiving chemotherapy, was shown to have leukemic infiltration of lung tissue, and subsequently had complete resolution of lung infiltrates following initiation of chemotherapy.
Hybride stadsregionaal bestuur belicht: effectiviteit en legitimiteit in vier grootstedelijke gebieden
Authors: Schaap Linze , Colombo Carlo , Damen Maaike , Karsten Niels 
Published: June 2018

Hybrid city-regional governance. Effectiveness and legitimacy in four metropolitan areas
This article reports on an analysis of the effectiveness and legitimacy of modes of governance in four European regions that clearly show signs of hybridity, that is, they have private as well as public characteristics. Berlin, Eindhoven, Copenhagen-Malmö and Zurich thus aim to increase the problem-solving capacity of their regional governance and to govern ‘smartly’ in a complex and multi-level context. The individual cities search for effective links with private and societal actors, each in its own way. Legitimacy is an issue that is hardly reflected upon, though. Hybrid modes of governance may have negative impacts on both effectiveness and legitimacy, but also offer new opportunities for good governance. ‘Hybrid’ and ‘smart’ do not always go hand in hand, but they are not mutually exclusive either.
De dynamiek van slimme sturing voor de verduurzaming van handelsketens
Authors: Termeer Katrien , Toonen Hilde , Kok Marcel , Turnhout Esther 
Published: June 2018

The dynamics of smart governance for sustainable value chains
Traditional state-centered governance systems have failed to effectively tackle the transnational problem of the sustainability of global value chains (GVCs). To fill this ‘institutional void’, industry and NGOs established a series of global partnerships that designed standards and certification schemes for global commodities. This paper uses different theoretical lenses to address the question as to what extent these arrangements can be evaluated as smart, and for what and for whom they are smart? Despite their relative success, these partnerships face some serious challenges. Consequently, smart governance also requires adaptiveness and the prevention of path dependencies.
Lokale netwerken als instrument voor centraal beleid?
Authors: De Rynck Filip , Temmerman Caroline , Voets Joris 
Published: June 2018

Local networks as an instrument for central policy? The relativity of metagovernance
Collaboration between public actors and social partners is becoming increasingly important as an administrative solution for complex societal challenges in health care, spatial development, mobility management or water management. In this article we focus on the relationship between the central Flemish government and local networks that are set up by this government. In the scientific literature much attention is paid to the concept of metagovernance as analytical perspective to analyze the relationship between the government and networks. The concept offers the government a toolbox with roles and instruments from which it can choose to support and stimulate networks in order to achieve the desired network results. However, our research shows that such an approach is not sufficient to capture the relationship between the central government and local mandated networks in Flanders. We argue for a broader interpretation of the concept of metagovernance, in which the dynamics of local networks are viewed as the outcome of power relations between actors that are represented at both local and central level and that are intertwined with each other. Only in this way will we we understand why certain choices are made about local mandated networks, why local networks show a lack of dynamism and why local actors in local networks also do not want local networks to become more dynamic and effective. We do notice that the pressure on these arrangements is increasing, partly due to new actors who are not involved in these arrangements.
Waarderen of veroordelen?
Authors: Bleijenberg Christine , Aarts Noëlle , Renes Reint Jan 
Published: June 2018

Appreciating or condemning? The significance of critical citizens who do not take part for local participation processes
To be able to realize the ambitions of citizen participation, diversity of participants is a crucial condition. At the same time excluding groups of citizens, amongst them critical citizens, is inextricably linked with citizen participation. In this article in the series ‘Local democratic audit’, the authors wonder what the exclusion of critical citizens means for the process and outcome of citizen participation. Through two empirical studies during a spatial intervention in different municipalities in the Netherlands, they investigated how people involved in a participation process spoke about critical citizens and their manifestations. The results show that the way these critical citizens are discussed either legitimizes exclusion or questions it critically. The legitimization of exclusion is detrimental to the support for spatial intervention. The problematization of exclusion results in a responsive approach to critical citizens, which is beneficial for both the course of the participation process and for the support for the spatial intervention.
The New Consumer Deal
Authors: van Hattum B. 
Published: June 2018

The New Consumer Deal. Een gamechanger op het gebied van de afwikkeling van massaclaims in Europa en specifiek Nederland als marktleider?
De Europese Commissie heeft als onderdeel van een New Consumer Deal (hierna: de Deal) een richtlijnvoorstel gepubliceerd waar de invoering van een groepsvordering in de Europese Unie wordt voorgesteld om te kunnen garanderen dat de Europese consument ten volle van zijn rechten als EU-burger kan genieten. De Commissie kiest voor het toebedelen van de groepsvordering aan een met specifieke voorwaarden omklede entiteit. In de praktijk zal dit neerkomen op het toekennen van een groepsvordering aan een consumentenvereniging, een voor een specifieke vorm van massaschadeafwikkeling opgerichte en door de overheid ondersteunde stichting en/of een toezichthouder. In hoeverre is deze keuze van de Commissie een gamechanger in het speelveld van massaschadeafwikkeling en zal de invoering van een groepsvordering bijdragen aan het door de commissie beoogde doel van het waarborgen van de rechten van de EU-burger?Voorstel betreffende representatieve vorderingen ter bescherming van de collectieve belangen van consumenten en tot intrekking van Richtlijn 2009/22/EG. Brussels 11 april 2018, COM(2018)184 final 2018/0089 (COD).
Kroniek Handvest van de Grondrechten van de Unie periode 2016-2017: actieve grondrechtenbescherming vanuit Luxemburg
Authors: Pahladsingh A. 
Published: June 2018

Kroniek Handvest van de Grondrechten van de Unie periode 2016-2017: actieve grondrechtenbescherming vanuit Luxemburg
Het Handvest van de Grondrechten van de EU is sinds 1 december 2009 ruim zeven jaar juridisch bindend. Het heeft als doel grondrechtenbescherming te versterken door relevante rechten beter zichtbaar te maken. In deze kroniek wordt een overzicht gegeven van de belangrijkste ontwikkelingen over 2016 en 2017, bezien vanuit het Hof van Justitie. Om een goed beeld te geven over de afgelopen twee jaar is gekozen voor een overzicht van de belangrijkste ontwikkelingen per artikel uit het Handvest.