bluuebunny/crossref_metadata_2025_split huggingface dataset:
The experiences of children with autism spectrum disorder, their caregivers and health care providers during day procedure: A mixed methods study
Authors: Taghizadeh Neda , Heard Gaylene , Davidson Andrew , Williams Katrina , Story David 
Published: August 2019

AbstractBackgroundAutism Spectrum Disorder is now diagnosed in more than 1% of children in Australia and USA. Children with autism spectrum disorder may have additional health care needs, require more specialized services for their health care, or experience more difficulties during hospital attendance. Customized care for these children may assist in decreasing potentially challenging behaviours during hospitalization. The purpose of this study was to explore the experiences of children with autism spectrum disorder and their caregivers during attendance for day procedures in two hospitals in Melbourne, Australia. Further, the perceptions of their health care providers were explored.MethodsTwenty‐nine participants, including 14 health care providers and 15 caregivers of children with autism spectrum disorder, were interviewed within 72 hours of their day procedure attendance at the Royal Children's Hospital and the Royal Dental Hospital in Melbourne, Australia. Interviews were recorded digitally, then transcribed and coded. Mixed quantitative and qualitative methods (content analysis) were used.ResultsHospital attendance was often stressful. Participants identified a number of facilitating factors including good communication, clear explanations, and friendly attitudes of staff. Flexibility and individualized care of patients (such as avoiding unnecessary blood pressure measurements, and not changing into hospital gowns) were valued. Supportive aids (such as computers or special interest objects), use of social stories, and giving premedication were all considered helpful.Perceived barriers to care included prolonged waiting times for operation date as well as waiting on the day of operation, lack of private space, lack of noninvasive equipment such as cutaneous infrared thermometers, poor communication, and inadequate training of staff about autism spectrum disorder.ConclusionProviding optimal care for children with autism spectrum disorder requires a multifaceted approach that may require changes to hospital work flow, staff training, better use of aids (such as tablet computers and social stories), and premedication. Good communication and flexibility are key areas of importance.
Endocrinological characterization of an ovarian sex cord–stromal tumor with a Sertoli cell pattern in a Japanese Black cow
Authors: El‐Sheikh Ali Hossam , Kitahara Go , Nibe Kazumi , Osawa Takeshi 
Published: August 2019

AbstractA Japanese Black cow was evaluated for prolonged post‐partum anestrus and enlargement of the right ovary. Transrectal ultrasonography revealed that the right ovary was markedly enlarged and had a solid appearance, while the left ovary was small and inactive. The presumptive diagnosis was directed towards granulosa‐theca cell tumour (GTCT) which was supported by markedly elevated plasma anti‐Müllerian hormone (AMH; 332.0 ng/ml), oestradiol (E2; 103.3 pg/ml) and immunoreactive inhibin (ir‐INH; 2.1 ng/ml) in comparison with the diagnostic cut‐off points for bovine GTCTs. Since the cow had been infertile and had swelling of the udder, slaughter was chosen. Histopathological examination revealed that the tumour was an ovarian sex cord–stromal tumour (SCST) with a Sertoli cell pattern. These findings suggest that plasma AMH, ir‐INH and E2 could be possible biomarkers for bovine ovarian SCST with a Sertoli cell pattern, whereas this case could not be distinguished from GTCTs based on endocrinological profile.
A Systematic Review of the Evidence Supporting Mobile‐ and Internet‐Based Psychological Interventions For Self‐Harm
Authors: Arshad Usman , Farhat‐ul‐Ain  , Gauntlett Jessica , Husain Nusrat , Chaudhry Nasim , Taylor Peter James 
Published: August 2019

ObjectivesInternet‐ and mobile phone‐based psychological interventions have the potential to overcome many of the barriers associated with accessing traditional face‐to‐face therapy. Self‐injurious thoughts and behaviors (STB) are prevalent global health problems that may benefit from Internet‐ and mobile‐based interventions. We provide a systematic review and meta‐analysis of studies evaluating mobile‐ and Internet‐based interventions for STB, including nonsuicidal self‐injury (NSSI).MethodsOnline databases (PsycINFO, Web of Science, Medline) were searched up to March 2019 for single‐arm and controlled trials of Internet‐ or mobile‐based interventions for STB. The potential for bias was assessed using the Cochrane risk of bias tool.ResultsTwenty‐two eligible trials were identified. The research was limited by a lack of controlled designs and small samples. Evidence supports the acceptability of interventions. There is preliminary evidence that these interventions are associated with a decline in STB. A meta‐analysis suggested a positive treatment effect on suicidal ideation when compared to treatment as usual, but not when trials with active controls were also considered.ConclusionsOverall, Internet‐ and mobile‐based interventions show promise and further controlled trials are warranted, focusing on behavioral outcomes (NSSI, suicidal behavior).This review was preregistered with PROSPERO (CRD42017074065).
Caveolae: The FAQs
Authors: Parton Robert G. , del Pozo Miguel A. , Vassilopoulos Stéphane , Nabi Ivan R. , Le Lay Soazig , Lundmark Richard , Kenworthy Anne K. , Camus Anne , Blouin Cedric M. , Sessa William C. , Lamaze Christophe 
Published: August 2019

AbstractCaveolae are an abundant, but enigmatic, plasma membrane feature of vertebrate cells. In this brief commentary, the authors attempt to answer some key questions related to the formation and function of caveolae based on round‐table discussions at the first EMBO Workshop on Caveolae held in France in May 2019.
Antivenin‐associated serum sickness in a dog
Authors: Lee Benjamin M. , Zersen Kristin M. , Schissler Jennifer R. , Sullivan Lauren A. 
Published: August 2019

AbstractObjectiveTo describe a case of documented serum sickness in a dog following administration of a single dose of a novel antivenin crotalidae polyvalent.Case SummaryA 4‐year‐old female neutered mixed breed dog developed recurrent signs of hypersensitivity (swelling, edema, urticaria/hives, gastrointestinal signs, vasculitis) at 1 and 2 weeks following administration of a single unit of a novel antivenin crotalidae polyvalent plasma product. Both episodes were treated with antihistamines and glucocorticoids and signs improved rapidly, with a prolonged course of glucocorticoids and antihistamines administered following the second occurrence. Diagnosis of serum sickness was based on clinical appearance of delayed hypersensitivity following exposure to novel biologic product, absence of other inciting cause of hypersensitivity, complement testing, and skin biopsies confirming vasculitis.New or Unique Information ProvidedThis case documents the first report of delayed hypersensitivity with a novel antivenin plasma product. This is the only case report of serum sickness to a single unit of antivenin. Additionally, the dog developed recurrence of hypersensitivity following the initial episode at 1 week; appropriate identification and prolonged treatment could have prevented recurrence and additional hospitalization. Cost and benefit analysis should be considered with antivenin administration.
Effects of team-based goals and non-monetary incentives on front-line health worker performance and maternal health behaviours: a cluster randomised controlled trial in Bihar, India
Authors: Carmichael Suzan L , Mehta Kala , Raheel Hina , Srikantiah Sridhar , Chaudhuri Indrajit , Trehan Shamik , Mohanty Sunil , Borkum Evan , Mahapatra Tanmay , Weng Yingjie , Kaimal Rajani , Sivasankaran Anita , Sridharan Swetha , Rotz Dana , Tarigopula Usha Kiran , Bhattacharya Debarshi , Atmavilas Yamini , Munar Wolfgang , Rangarajan Anu , Darmstadt Gary L 
Published: August 2019

IntroductionWe evaluated the impact of a ‘Team-Based Goals and Incentives’ (TBGI) intervention in Bihar, India, designed to improve front-line (community health) worker (FLW) performance and health-promoting behaviours related to reproductive, maternal, newborn and child health and nutrition.MethodsThis study used a cluster randomised controlled trial design and difference-in-difference analyses of improvements in maternal health-related behaviours related to the intervention’s team-based goals (primary), and interactions of FLWs with each other and with maternal beneficiaries (secondary). Evaluation participants included approximately 1300 FLWs and 3600 mothers at baseline (May to June 2012) and after 2.5 years of implementation (November to December 2014) who had delivered an infant in the previous year.ResultsThe TBGI intervention resulted in significant increases in the frequency of antenatal home visits (15 absolute percentage points (PP), p=0.03) and receipt of iron-folic acid (IFA) tablets (7 PP, p=0.02), but non-significant changes in other health behaviours related to the trial’s goals. Improvements were seen in selected attitudes related to coordination and teamwork among FLWs, and in the provision of advice to beneficiaries (ranging from 8 to 14 PP) related to IFA, cord care, breast feeding, complementary feeding and family planning.ConclusionResults suggest that combining an integrated set of team-based coverage goals and targets, small non-cash incentives for teams who meet targets and team building to motivate FLWs resulted in improvements in FLW coordination and teamwork, and in the quality and quantity of FLW–beneficiary interactions. These improvements represent programmatically meaningful steps towards improving health behaviours and outcomes.Trial registration numberNCT03406221
HMGB1 involved in stress-induced depression and its neuroinflammatory priming role: a systematic review
Authors: Zhang Huifeng , Ding Lei , Shen Ting , Peng Daihui 
Published: August 2019

BackgroundEvidence from clinical and preclinical studies has demonstrated that stress can cause depressive-like symptoms including anhedonia and psychomotor retardation, namely, the manifestation of motivational deficits in depression. The proximate mediator of linking social-environmental stress with internal motivational deficits remains elusive, although substantial studies proposed neural endocrine mechanisms. As an endogenous danger-associated molecule, high mobility group box-1 (HMGB1) is necessary and sufficient for stress-induced sensitization of innate immune cells and subsequent (neuro)inflammation.AimThis review aims to provide evidence to unveil the potential mechanism of the relationship between motivational deficits and stress in depression.MethodsWe reviewed original case-control studies investigating the association between HMGB1-mediated inflammation and stress-induced depression. The literature search of Pubmed and Web of Science electronic database from inception up to March 28th, 2019 were conducted by two independent authors. We performed a qualitative systematic review approach to explore the correlation between HMGB1-mediated inflammation and anhedonia/psychomotor retardation in depression.ResultsA total of 69 studies based on search strategy were retrieved and seven eligible studies met the inclusion criteria. Studies showed that HMGB1 was implicated with depressive-like behaviors, which are similar with motivational deficits. Furthermore, HMGB1-mediated inflammation in depressive-like behaviors may be involved in Nod-like receptor family pyrin domain containing three (NLRP3) inflammasome and proinflammatory cytokines, abnormal kynurenine pathway and imbalance between neuroprotective and neurotoxic factors.ConclusionsWe found that stress-induced inflammation mediated by HMGB1 may affect motivational deficits through regulating dopamine pathway in corticostriatal neurocircuitry. The systematic review may shed light on the novel neurobiological underpinning for treatment of motivation deficits in depression.
Combined Dynamical and Statistical Downscaling for High-Resolution Projections of Multiple Climate Variables in the Beijing–Tianjin–Hebei Region of China
Authors: Han Zhenyu , Shi Ying , Wu Jia , Xu Ying , Zhou Botao 
Published: August 2019

AbstractHigh-resolution combined dynamical and statistical downscaling for multivariables (HDM) was performed in the Beijing–Tianjin–Hebei (BTH) region by using observations from China Meteorological Administration Land Data Assimilation System (CLDAS), a regional climate model (RCM), and quantile mapping. This resulted in the production of a daily product with six variables (daily mean, maximum, and minimum temperature; precipitation; relative humidity; and wind speed), five ensemble members, a multidecadal time span (1980–2099), and a high resolution (6.25 km) for climate change projections under the RCP4.5 scenario. The evaluation showed that the HDM output could reproduce well the mean states of all variables and most extreme indices except the consecutive dry and wet days. The biases in the magnitude of interannual variability in HDM were mostly inherited from the RCM. By using the HDM, future projection over BTH was conducted. The results indicated that the annual mean temperature and precipitation as well as extreme heat and heavy precipitation events will increase over most regions. The warming magnitudes over the mountainous and coastal area at the northern BTH and the wetting magnitudes over the Daqinghe River basin (DRB) within BTH will be relatively stronger. The increases in extreme heat events will be much larger in the plain area. More than one-half of regions with the large extreme precipitation increase will be located within DRB. Both the number of models with the same sign of change and the ensemble standard deviation were used to estimate the projection uncertainty. The projected changes and uncertainties over DRB and subregions and Xiong’an city within the basin for each season are also discussed.
Attribution of Recent Trends in Temperature Extremes over China: Role of Changes in Anthropogenic Aerosol Emissions over Asia
Authors: Chen Wei , Dong Buwen , Wilcox Laura , Luo Feifei , Dunstone Nick , Highwood Eleanor J. 
Published: August 2019

ABSTRACT
Observations indicate large changes in temperature extremes over China during the last four decades, exhibiting as significant increases in the amplitude and frequency of hot extremes and decreases in the amplitude and frequency of cold extremes. An ensemble of transient experiments with the fully coupled atmosphere–ocean model HadGEM3-GC2, including both anthropogenic forcing and natural forcing, successfully reproduces the spatial pattern and magnitude of observed historical trends in both hot and cold extremes. The model-simulated trends in temperature extremes primarily come from the positive trends in clear-sky longwave radiation, which is mainly due to the increases in greenhouse gases (GHGs). An ensemble of sensitivity experiments with Asian anthropogenic aerosol (AA) emissions fixed at their 1970s levels tends to overestimate the trends in temperature extremes, indicating that local AA emission changes have moderated the trends in these temperature extremes over China. The recent increases in Asian AA drive cooling trends over China by inducing negative clear-sky shortwave radiation directly through the aerosol–radiation interaction, which partly offsets the strong warming effect by GHG changes. The cooling trends induced by Asian AA changes are weaker over northern China during summer, which is due to the warming effect by the positive shortwave cloud radiative effect through the AA-induced atmosphere–cloud feedback. This accounts for the observed north–south gradients of the historical trends in some temperature extremes over China, highlighting the importance of local Asian AA emission changes on spatial heterogeneity of trends in temperature extremes.
CVI Experience toolbox: Simulation of visual processing difficulties
Authors: Pilon-Kamsteeg Florine , Dekker-Pap Marjoke J , de Wit Gerard C , van Genderen Maria M 
Published: August 2019

We designed a cerebral visual impairment (CVI)–experience toolbox containing simulation exercises to let professionals experience the complexity of visual information processing and to get an impression of what it means to have CVI. We measured the benefits of the CVI Experience toolbox by using questionnaires during three CVI seminars with professionals ( n = 69). These seminars started with a slide presentation on CVI followed by the CVI experience toolbox. We presented the professionals with the same survey on their knowledge of CVI at the start of the seminar, after the presentation, and after the toolbox. Professionals with more previous CVI experience started on average with a higher score. The final end score, however, did not seem to depend on previous experience. Furthermore, the added value of the experience toolset was quite independent of the added value of the presentation. The results indicate that both the presentationand the experience toolboxadd to the understanding of CVI.
Effectiveness of repeated antivenom therapy for snakebite-related systemic complications
Authors: Park Kyung Hoon , Shin Hyungoo , Kang Hyunggoo , Kim Changsun , Choi Hyuk Joong , Yoo Kyunghun , Oh Jaehoon , Lim Tae Ho 
Published: August 2019

Objective This study aimed to determine the effect of repeated antivenom therapy compared with that of single antivenom therapy for treating snakebite-related systemic complications. Methods A retrospective medical record review from January 2008 to September 2016 was performed. Patients with snakebite injury who visited the Emergency Department in one tertiary center of Korea were included. The primary outcome was the survival rate. The secondary outcome was the effect of repeated antivenom therapy for treating snakebite-related systemic complications compared with that of single antivenom therapy on hospital length of stay. Results A total of 110 patients with snakebites were included. All patients survived to discharge. Twenty-nine (26.4%) patients had snakebite-related systemic complications. Of these, nine patients received repeated antivenom therapy and 20 patients received single antivenom therapy. The length of stay was significantly longer in those who received repeated antivenom therapy compared with those who received single antivenom therapy (10.0 [4.0–11.0] vs. 3.5 [0–7.0] days). Conclusion We were unable to demonstrate any superiority of repeated versus single antivenom therapy. However, repeated antivenom therapy is associated with a longer hospital stay. The reason for this finding is unknown.
Assessment of biological parameters in head and neck cancer based on in vivo distribution of 18F-FDG-FLT-FMISO-PET/CT images
Authors: Cegla Paulina , Kazmierska Joanna , Gwozdz Sebastian , Czepczynski Rafal , Malicki Julian , Cholewinski Witold 
Published: August 2019

Objective: Several genetic analyses have identified tumor diversity not only among tumors from different patients (intertumor heterogeneity) but also within individual tumors (intratumor heterogeneity). The aim of this study was to analyze the intratumor heterogeneity and other biological parameters based on in vivo distribution in triple-tracer positron emission tomography with computed tomography (PET/CT) study in patients with newly diagnosed head and neck (H&N) cancer. Methods: Thirty-six patients with newly diagnosed H&N cancer were included in the study. Institutional Bioethical Committee approved the study protocol and informed consent was received from every participant. All patients underwent series of 3 PET/CT scans with [18F]Fluorodeoxyglucose (18F-FDG-PET), [18F]Fluorothymidine (18F-FLT-PET), and [18F]Fluoromisonidazole (18F-FMISO-PET) before treatment. Scans were performed on separate days, within a timeframe of 2 weeks. Several PET/CT parameters grading tumor biology including maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), its equivalent (total hypoxic lesion [TLH] and total proliferative lesion [TLP]), and heterogeneity (area under the curve–cumulative SUV histogram) for the primary tumor were compared. Results: All patients showed increased uptake of 18F-FDG in primary tumor, ranging from 2.29 to 14.89 SUVmax. Respectively, SUVmax values for 18F-FLT ranged from 0.93 to 16.11 and for 18F-FMISO 0.36–4.07. Based on 3-year follow-up, we divided patients in terms of survival forecasts (first with good prognosis and second with worse). Higher values of TLG/TLP/TLH and SUVmax were observed in the second group in all 3 tracers (for 18F-FDG: 167.40 vs 100.32, 11.15 vs 8.95; for 18F-FLT: 116.61 vs 60.67, 7.09 vs 5.47; for 18F-FMISO: 37.34 vs 22.30, 1.70 vs 1.61 respectively). Statistically significant differences were shown in SUVmax in 18F-FDG and 18F-FLT ( P<0.034, P<0.034, respectively; in TLG, P=0.05; TLP, P=0.04; and TLH, P=0.05). Conclusion: Our preliminary results suggest worse prognosis in patients with higher heterogeneity values of primary tumor in proliferation and hypoxia images and combination of metabolic and volumetric parameters in TLG and its equivalent and heterogeneity of primary tumor seems to be a prognostic factor.
Workload of breast image-guided intensity-modulated radiotherapy delivered with TomoTherapy
Authors: Ricotti Rosalinda , Miglietta Eleonora , Leonardi Maria Cristina , Cattani Federica , Dicuonzo Samantha , Rojas Damaris Patricia , Marvaso Giulia , Orecchia Roberto , Jereczek-Fossa Barbara Alicja 
Published: August 2019

Objective: To report treatment times (door to door) of adjuvant treatments of breast cancer (BC) with intensity-modulated radiotherapy (IMRT). Methods: Treatment times of 62 patients with BC on the TomoTherapy Hi-Art System were collected for the analysis. Patients underwent either locoregional radiotherapy (postmastectomy radiotherapy [PMRT]) with helical modality (TomoHelical) or whole breast radiotherapy (RT) with simultaneous integrated boost (WBRT-SIB) with direct modality (TomoDirect). Door-to-door time was broken down into different steps, which were crucial to RT session. Results: A total of 594 treatment fractions were monitored. Median treatment time was 22.4 minutes (17.2–30.8) for PMRT and 14.4 minutes (10.9–23.5) for WBRT-SIB. The mean beam-on time accounted for 61.36% of the overall treatment time for PMRT compared to 57% for WBRT-SIB. The beam-on time was a much more time-consuming process. Conclusion: This treatment times analysis on the use of IMRT for BC might be useful to organize and improve the workflow efficiency in RT facilities.
Postoperative Pain Management in Pediatric Patients Undergoing Cardiac Surgery: Where Are We Heading?
Authors: Pollak Uri , Bronicki Ronald A. , Achuff Barbara-Jo , Checchia Paul A. 
Published: August 2019

Objectives: Adequate postoperative pain management is crucial in pediatric patients undergoing cardiac surgery because pain can lead to devastating short- and long-term consequences. This review discusses the limitations of current postoperative pain assessment and management in children after cardiac surgery, the obstacles to providing optimal treatment, and concepts to consider that may overcome these barriers. Data Source: MEDLINE and PubMed. Conclusions: Effective pain management in infants and young children undergoing cardiac surgery continues to evolve with innovative methods of both assessment and therapy using newer drugs or novel routes of administration. Artificial intelligence– and machine learning–based pain assessment and patient-tailored management in both pain measurement and prevention are already being integrated into the routine of current practice.