bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous glucose monitoring in the management of patients after gastric bypass
Authors: Rodríguez Flores Marcela , Cruz Soto Ruth Carmina , Vázquez Velázquez Verónica , Soriano Cortés Reina Ruth , Aguilar Salinas Carlos , García García Eduardo 
Published: July 2019

Summary
In patients with gastric bypass (GB), high glucose variability (GV) and hypoglycemia have been demonstrated, which could impact the metabolic status and eating behavior. We describe the glucose patterns determined through continuous glucose monitoring (CGM) in two patients with >5 years follow-up after GB and significant weight recovery, who reported hypoglycemic symptoms that interfered with daily activities, and their response to a nutritional and psycho-educative prescription. Case 1: A 40-year-old woman without pre-surgical type 2 diabetes (T2DM) and normal HbA1c, in whom CGM showed high GV and hypoglycemic episodes that did not correlate with the time of hypoglycemic symptoms. Her GV reduced after prescription of a diet with low glycemic index and modification of meal patterns. Case 2: A 48-year-old male with pre-surgical diagnosis of T2DM and current normal HbA1c, reported skipping meals. The CGM showed high GV, 15% of time in hypoglycemia and hyperglycemic spikes. After prescription of a low glycemic index diet, his GV increased and time in hypoglycemia decreased. Through the detailed self-monitoring needed for CGM, we discovered severe anxiety symptoms, consumption of simple carbohydrates and lack of meal structure. He was referred for more intensive psychological counseling. In conclusion, CGM can detect disorders in glucose homeostasis derived both from the mechanisms of bariatric surgery, as well as the patient’s behaviors and mental health, improving decision-making during follow-up.

Learning points:

High glycemic variability is frequent in patients operated with gastric bypass.

Diverse eating patterns, such as prolonged fasting and simple carbohydrate ingestion, and mental health disorders, including anxiety, can promote and be confused with worsened hypoglycemia.

CGM requires a detailed record of food ingested that can be accompanied by associated factors (circumstances, eating patterns, emotional symptoms). This allows the detection of particular behaviors and amount of dietary simple carbohydrates to guide recommendations provided within clinical care of these patients.
Metode inokulasi buatan untuk menguji infeksi Peronosclerospora maydis penyebab penyakit bulai tanaman jagung
Authors: Adhi Satriyo Restu , Widiantini Fitri , Yulia Endah 
Published: July 2019

Keberadaan penyakit bulai akibat Peronosclerospora maydis pada tanaman jagung mampu menyebabkan kehilangan hasil hingga 100%. Pengendalian penyakit bulai dengan menggunakan varietas tahan dinilai cukup efektif. Di dalam pengembangan varietas tahan, seleksi ketahanan calon varietas baru harus dilakukan dan hal ini akan melibatkan inokulasi buatan. Tujuan dari penelitian ini adalah untuk mendapatkan metode inokulasi buatan Peronosclerospora maydis yang efektif pada tanaman jagung pada skala rumah kaca. Penelitian dilaksanakan di Laboratorium Bioteknologi Proteksi Tanaman dan rumah kaca Departemen Hama dan Penyakit Tumbuhan, Fakultas Pertanian, Universitas Padjadjaran pada bulan Oktober hingga Desember 2018. Bahan tanaman yang diinokulasikan berupa kecambah dan bibit tanaman jagung. Metode inokulasi buatan yang diujikan terdiri atas: (1) Sisip daun terinfeksi bulai pada kecambah (SD), (2) Semprot suspensi konidia pada kecambah (SI), (3) Sisip daun bergejala bulai + semprot suspensi konidia pada kecambah (SS), (4) Rendam kecambah pada suspensi konidia (RS), (5) Semprot suspensi konidia pada bibit (SB), dan dua perlakuan tanpa inokulasi (kontrol). Dari hasil percobaan metode sisip daun (SD) menyebabkan 83,3% tanaman jagung terinfeksi bulai dan dinilai sebagai metode inokulasi buatan yang efisien.Kata kunci: bulai, jagung, inokulasi buatan, Peronosclerospora maydis. ABSTRACTDowny mildew disease caused by Peronosclerospora maydis in maize plants can cause yield loss up to 100%. Disease management of downy mildew by using resistant varieties is considered quite effective. One of the steps to develop resistant varieties is resistance testing of the new variety candidates that involve artificial inoculation. The purpose of this study was to obtain an effective artificial inoculation method of Peronosclerospora maydis in maize plants in greenhouse. The research was conducted at the Laboratory of Biotechnology of Plant Protection and Glasshouse Department of Plant Pests and Diseases, Agriculture Faculty, Universitas Padjadjaran from October to December 2018. The plant materials used for inoculation were sprout and seedling of maize plant. The artificial inoculation methods tested were (1) infected leaf insertion among the sprouts (SD), (2) conidia suspension spraying on the sprouts (SI), (3) infected leaf insertion + conidia suspension spraying on the sprouts (SS), (4) sprout soaking in conidia suspension (RS), (5) conidia suspension spraying on the seedling (SB), and two treatments without inoculation (controls). The result showed that the insertion of infected leaves among the sprouts (SD) treatment resulted in 83.3% of infected maize plants by the downy mildew and was considered as the most efficient inoculation method.
New proteasome inhibitors in the management of multiple myeloma
Authors: Semochkin S. V. 
Published: July 2019

The landscape of multiple myeloma treatment transformed at the last 15 years by the introduction of novel agents (bortezomib, lenalidomide) and wide application of autologous hematopoietic stem cell transplantation, which have prolonged the survival of multiple myeloma patients. Despite the fact that multiple myeloma remains an incurable disease due to the new options, the median overall survival of patients with multiple myeloma in Russia in 2006–2016 was about 55–68 months. Drug resistance and clonal evolution remain a problem. The novel proteasome inhibitors (carfilzomib, ixazomib) differ in chemical structure and pharmacological characteristics. Thereby the next-generation proteasome inhibitor (IPs)-based regimens (KRd (carfilzomib, lenalidomide, dexamethasone), IRd (ixazomib, lenalidomide, dexamethasone), and Kd (carfilzomib, dexamethasone)) are emerging as new standards for the treatment of patients with relapsed and/or refractory multiple myeloma. In a randomized trial phase 3 ENDEAVOR, carfilzomib demonstrated improved survival in direct comparison to bortezomib. The dose-dependent activity of carfilzomib demonstrated in the study of A.R.R.O.W. Аctivity of ixazomib is comparable to that of bortezomib, the oral method of administration and the absence of neurological toxicity, allow for long-term control of the disease. The new PIs are an important advance in relapsed and/or refractory multiple myeloma treatment, increasing survival, response rate and quality of life, even in subgroups of patients with poor prognosis. This review summarizes the main pharmacological properties, mechanisms of action and clinical outcomes of major clinical studies with these agents. A separate issue discusses the problem of overcoming new proteasome inhibitors of drug resistance to bortezomib.
Subpopulations of mobilized hematopoietic stem cells in patients with hematological malignances and donors: expression of CD38, HLA-DR and CD143
Authors: Kanaeva M. L. , Galtseva I. V. , Parovichnikova E. N. , Davydova Yu. O. , Gaponova T. V. , Gribanova E. O. , Balzhanova Ya. V. , Kuzmina L. A. , Troitskaya V. V. , Kravchenko S. K. , Zvonkov E. E. , Mendeleeva L. P. , Savchenko V. G. 
Published: July 2019

The study objectiveis to investigate the features of subpopulational composition of mobilized hematopoietic stem cells in peripheral blood (PB) and leukocyte concentrates (LC) in adult patients with oncohematological pathology and donors.Materials and methods. In 80 patients with hemoblastoses, expression of CD38, HLA-DR and CD143 (angiotensin-converting enzyme) was measured in PB and LC CD34+CD45low cells. The control group included 10 PB and 14 LC samples from healthy donors. Analysis of PB was performed prior to mobilization of hematopoietic stem cells (HSC) and on the day of leukapheresis prior to HSC collection. LC samples were examined at day 1 after HSC collection.Results.CD143 is expressed on CD34+CD45low cells both prior to mobilization and after it in all patients and donors, but CD34+CD45lowCD143+ cell counts varied depending on diagnosis and mobilization regimen. CD143+ expression on CD34+CD45low cells was significantly higher in patients who received combination of chemotherapy and granulocyte colony-stimulating factor compared to donors and patients with multiple myeloma who received only granulocyte colony-stimulating factor. Along with elevated CD34+CD45low cell count after hematopoiesis stimulation, CD34+CD45lowCD143+ cell counts also increased. It was shown that mobilized HSC almost completely lacks a fraction of early CD34+CD45low progenitor cells not expressing CD38, HLA-DR. Prior to hematopoiesis stimulation among CD34+CD45low cells, CD38+HLADR–cell fractions are prevalent, but after mobilization CD38–HLA-DR+ cell counts increased. No differences between CD34+CD45lowCD143+cell counts in patients with multiple myeloma depending on disease status, sex, age or number of chemotherapy courses prior to HSC mobilizationwere observed.Conclusion. Expression of angiotensin-converting enzyme on CD34+ cells in PB before and after HSC mobilization and in LC was observed. The cell counts varied depending on diagnosis and mobilization regimen.
Ex vivo-model design and evaluation of the sensitivity of blast cells to chemotherapy as a way to personalize the treatment of acute myeloid leukemia
Authors: Polyakov A. S. , Noskov Ya. A. , Nikitin Yu. V. , Tyrenko V. V. , Kolubaeva S. N. , Bogdanov A. N. , Semelev V. N. , Petrova O. R. , Bondarchuk S. V. , Zhogolev D. K. , Zolotarev A. D. , Kovalev A. V. , Puchkova Yu. E. 
Published: July 2019

Despite continuous attempts to improve therapy, the outcomes of acute myeloid leukemia remain almost unchanged over last decades. Drugs made with a more complete understanding of the biology of acute myeloid leukemia do not equal the hopes for better prognosis. The best results are achieved only with high-dose chemotherapy, which is only possible for a limited number of patients. High phenotypic and genotypic heterogeneity of acute myeloid leukemia defines the relevance to develop personalized approaches to therapy, including those based on determination of individual drug sensitivity of blast cells.This article presents the results of developing an ex-vivo model of acute myeloid leukemia, as well as testing of two in vitro sensitivity assessment methods: evaluation of the genotoxicity of drugs in the micronucleus test and vitality and sensitivity to chemotherapy in sorted blast cells. Prospects of individualized therapy of acute myeloid leukemia were determined based on introduction into clinical practice and continuing the research.
The role of tissue factor in metastasising, neoangiogenesis and hemostasis in cancer
Authors: Kovalenko T. A. , Panteleev M. A. , Sveshnikova A. N. 
Published: July 2019

Tissue factor, being the main initiator of the blood coagulation in vivo, is involved in a number of physiological processes, such as angiogenesis or cell migration. These processes are not only significant for normal physiology, but also play a role in the development and progression of oncological diseases. This review presents data on the structure of tissue factor, its expression in normal conditions and in cancer, its role in thrombosis development associated with cancer, in angiogenesis and in metastasis. The involvement of tissue factor in such a wide range of physiological processes important for the progression of cancer makes it an attractive target molecule for therapy.
The experience of free light chains of immunoglobulin elimination in patients with monoclonal gammopathies
Authors: Gromova E. G. , Zeynalova P. A. , Lubimova N. V. , Timofeev Yu. S. , Kushlinskiy N. E. , Semenova A. A. , Lunin V. V. , Kluchagina Yu. I. 
Published: July 2019

The objective of study is to estimate the efficiency of extracorporeal free light chains of immunoglobulin elimination in patients with monoclonal gammopathies (n = 12) during hemodialysis using selective filters.Materials and methods. A blood and dialysate free light chains concentrations change was criterion of efficiency.Results and conclusion. The selective free light chains filtration give the possibility of an adequate anti-tumor therapy, could prevent the development of irreversible renal failure and hypoalbuminemia.
HISTORIOGRAPHY, SOURCES AND METHODOLOGY OF STATE POLICY STUDYING IN THE SPHERE OF PROVIDING NATIONAL SECURITY OF THE RUSSIAN FEDERATION
Authors: Shturba E. V. 
Published: July 2019

The article presents detailed review of works and opinions of different researchers on the problem of studying the state policy of the Russian Federation in the sphere of national security. Historical publications, works of classical scholars, publicists, politicians and public figures have been analyzed. The methology of studying the establishment and development of national security in the Russian Federation has been considered.
DEVELOPMENT OF EDUCATION ON KUBAN TERRITORY DURING THE PERIOD OF 1793 – 1863 AND INFLUENCE OF CULTURAL TRADITIONS OF ZAPOROZHSKAYA SECH ON IT
Authors: Shturba V. A. , Vasiliev S. S. 
Published: July 2019

The article analyzes the policy of public education, which appeared in Cossack settlements in Kuban after 1793. The influence of cultural traditions belonging to the previous Cossack place of living (Zaporozhsraya Sech) on the policy has been shown. The overview of forms and methods of spiritual and moral assimilation of local tribes and ationalities has been given. The peculiar features of schools in Cossack villages have been presented.
MODERNIZATION OF THE POLITICAL SYSTEM AND ATTEMPTS TO FORM THE NATIONAL SECURITY CONCEPT IN RUSSIA DURING 1992 - 1997
Authors: Shturba Ye. B. 
Published: July 2019

The article considers the attempts to form the concepts of national security in the Russian Federation during 1992 – 1997 as the main condition for establishment of the new Russian statehood. The negative processes of 1991 – 1993 that led the state administration system to crisis have been discovered and analyzed from the standpoint of scientific criticism.
Predictors of Functional Improvements After Therapeutic Yoga Intervention for People with Parkinson’s Disease
Authors: Adams Em V. , Van Puymbroeck Marieke , Walter Alysha , Hawkins Brent L. , Schmid Arlene A. , Sharp Julia L. 
Published: July 2019

Abstract
Parkinson’s disease (PD) affects nearly 10 million people worldwide, leading to decreased mobility and balance and potential loss of independence. Yoga has been associated with improved function for people with PD, but the predictive factors for improved functional outcomes as a result of yoga participation remain unexamined. The objective of this secondary data analysis was to identify predictive factors of functional improvement for people with PD after an 8-week yoga intervention. Stepwise multiple linear regression was used to identify significant predictors of improvement in balance, fall control, PD symptoms, and activity constraints. Lower cognitive functioning was predictive of improvement in perceived control over falls, body responsiveness was predictive of improvement in PD-specific symptoms, and gait velocity was predictive of improvement in balance and activity constraints. Future research is warranted to evaluate the use of screeners to predict who is the best fit for yoga therapy. Additional research is needed to evaluate the need to include cognitive self-management training concurrent with yoga therapy.
Fecal carriage of carbapenem resistant Enterobacteriaceae among the intensive care unit patients
Authors: . Naina , Deep Antariksh , Chaudhry Dhruva , Yadav Aparna 
Published: July 2019

Background: The war against multidrug-resistant bacteria is challenging and of global concern. Hospitals are increasingly plagued by resistant gram negative pathogens. Bacteria of the family Enterobacteriaceae such as Escherichia coli and Klebsiella pneumoniae are part of the normal human intestinal flora but are also often responsible for community- and healthcare-associated infections. These bacteria are prone to acquiring resistance genes.Methods: Rectal swabs/swabs from the peri-anal area of the patients who were admitted in the Intensive Care Unit (ICU) of the accident and emergency department of this teaching hospital. Swabs were collected first on day 1 of admission, then day 4, and thereafter weekly during the period of stay in the ICU. All the swabs were immediately inoculated into trypticase soy broth with one 10μg meropenem disc and were incubated overnight at 35±2ºC, ambient air. Next day, the broth was vortexed, and then sub-cultured onto a MacConkey agar plate. On the third day, MacConkey agar plates were examined for lactose fermenting (pink-coloured) colonies. The representative isolated colonies were subjected to conventional antimicrobial susceptibility testing by the Kirby Bauer Disc diffusion method following the CLSI guidelines to know the susceptibility to carbapenem and other antimicrobial agents. Carbapenemase production was done by a Modified Hodge Test (MHT) and Imipenem-EDTA test.Results: Out of 89 patients, carbapenem resistant Klebsiella pneumoniae and E. coli isolates were recovered from 35 (39.3%) patients i.e. Klebsiella pneumoniae isolates from fifteen patients and carbapenem resistant E. coli isolates from twenty patients. Prevalence of carbapenemase producing isolates was found to be 1.42%. Conclusions: Surveillance for CRE can definitely help reduce rates of healthcare associated infections.
A retrospective cross sectional study on neurological profile of children with congenital heart disease
Authors: Banerjee Asish , Mitra Meenakshi 
Published: July 2019

Background: Children with Congenital Heart Disease have associated structural neurological abnormalities and those surviving infancy are even subjected to various environmental factors which might contribute to neurological abnormalities. Hence the objective is to study the neurological abnormalities of children with Congenital Heart Disease.Methods: A retrospective cross-sectional observation study was conducted over the period of 3 years (June 2016-May 2019). Data were collected from medical records department of 121 children of 2-12 years of age diagnosed with congenital heart disease. Neurological examination findings and neuro imaging and EEG findings where relevant were noted. To assess the association of adverse neurological outcome and congenital heart disease, data analysis was performed using Fisher's exact test.Results: 38% children of 2-12 years of age with congenital heart disease had adverse neurological profile. Neurological abnormalities were significantly associated with cyanotic heart disease (p value 0.0001). Statistically significant association were found between congenital cyanotic heart disease and seizure (p value=0.04), hemi paresis (p value=0.039), brain abscess (p value=0.012) and coma (p=0.01).Conclusions: Congenital cyanotic heart disease has significant associations with neurological abnormalities in children. These results demand attention for the neurological health of the largely uncorrected cardiac disease in Indian children
Predictable factors for intervention with heparin free plasmapheresis in impending liver cell failure due to consumption of phosphorus rodenticide
Authors: Banjan Deepa S. , Sane Kavita , Wattamvar Sachchidanand , More Mahesh 
Published: July 2019

Background: Yellow phosphorus containing rodenticide poisoning are common in Adult critical care. They cause coagulopathy and liver cell failure in humans. Till date, only liver transplants had been advocated as the final treatment of fulminant liver failure occurring as a complication of rodenticide poisoning. In this study, an innovative Treatment approach was given to liver cell failure cases who had consumed yellow phosphorus paste.Methods: Retrospective analysis of case records of liver cell failure cases due to the consumption of phosphorus containing Rodenticide poisonings, were analysed for a period of 1 year from January 2018 to January 2019 in a public hospital. Medical case records were obtained from records department and Postmortem registers. Symptoms, signs, investigations, treatments, complications, and outcomes were tabulated.Results: Total 11 cases were studied. 8 cases of liver cell failure and coagulopathy in whom therapeutic heparin free plasmapheresis was given, recovered completely from liver cell failure. A significant drop in Haemoglobin, platelet count, PT INR Ratio and rise in serum alkaline phosphatase, were the predictable factors used for the intervention of therapy with 5 cycles of heparin free plasmapheresis to eliminate toxic effects of phosphorus on liver cells and in the blood. A comparative analysis of untreated cases (n=3) vs treated with plasmapheresis (n=8), showed a significant statistical difference (P <0.005) in outcomes with a degree of freedom=2.Conclusions: Plasmapheresis can be a therapeutic treatment for liver cell failure caused due to the consumption of yellow phosphorus. Predictable factors for impending liver cell failure in whom plasmapheresis will be of benefit are dependent upon prothrombin time, INR ratio, Liver enzymes and time interval between consumption and onset of liver cell failure.
Anatomical study on sciatic nerve variations in Andhra Pradesh, India
Authors: Kumari K. Lakshmi , Sushma M. , Raja A. , Latha D. Asha 
Published: July 2019

Background: The sciatic nerve is the largest and widest nerve in the body and is derived from ventral rami of spinal nerves L2 to S3. Sciatic nerve appears in the Gluteal region below Piriformis from Pelvic cavity by passing through Greater Sciatic foramen. In between the Ischial tuberosity and greater trochanter of Femur, it reaches the back of the thigh. At the superior angle of Popliteal fossa, it divides into Tibial and common Peroneal (fibular) nerves. The division varies, and it may occur within the pelvis, Gluteal, upper, mid and lower part of thigh. The anatomical variations of the level at which the Sciatic nerve divides is considered important by Neurosurgeons, Anaesthetists, Orthopaedicians and Surgeons.Methods: This study was conducted on 52 lower limbs to determine the level of sciatic nerve bifurcation and its variations on 26 embalmed human cadavers. The data was analyzed manually using numbers, frequencies and percentages.Results: The findings of this study states that in 2 limbs (3.84%) the nerve divided in the gluteal region; in 4 limbs (7.69%) in the pelvic region; in 10 limbs (19.23%) at the junction between upper and middle thigh. The highest incidence of division occurs in 36 limbs (69.23%) at the superior angle of the popliteal fossa.Conclusions: The findings of this study revealed that the majority of sciatic nerve divisions occur at the superior angle of popliteal fossa while some divided into other regions such as Pelvis, Gluteal and thigh regions.