bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insufficient Use of Corticosteroids without Immunosuppressants Results in Higher Relapse Rates in Takayasu Arteritis
Authors: Mutoh Tomoyuki , Shirai Tsuyoshi , Fujii Hiroshi , Ishii Tomonori , Harigae Hideo 
Published: October 2019

Objective.Although prednisolone (PSL) and immunosuppressants are key drugs for Takayasu arteritis (TA) treatment, there is limited evidence on the optimal PSL dose. The aim of this study was to investigate the correlation between the initial PSL dose and relapse in TA.Methods.We enrolled 105 patients with TA who satisfied the criteria of the Japanese Circulation Society and American College of Rheumatology from 1990 to 2015. The clinical characteristics and outcomes of patients with TA were retrospectively evaluated. The relapse-free period was assessed according to the difference in initial treatments.Results.Relapse was observed in 57 (59.4%) of 96 patients treated with immunosuppressive therapy at diagnosis during a median followup of 56 months. Male sex and younger age of onset were significantly associated with relapse. Although ≤ 30 mg/day PSL monotherapy was preferably prescribed for patients with lower inflammatory markers, compared with > 30 mg/day (87.2% vs 52.6%), a significantly higher relapse rate was observed in the ≤ 30 mg/day group (HR 1.78; p = 0.047). Further, the relapse-free period was longer in patients treated with ≥ 50 mg/day PSL compared with those treated with ≤ 40 mg/day PSL. Combination therapy improved the relapse-free period compared with PSL monotherapy in the short term. The initial PSL dose was not associated with adverse events.Conclusion.A higher dose of PSL was associated with a significant decrease in the relapse rate. The effect of combination therapy on relapse needs to be further investigated. Lower-dose PSL monotherapy is an undesirable strategy for remission induction in TA, despite low disease activity.
Copy Number Variation of Multiple Genes in SAPHO Syndrome
Authors: Guo Changlong , Tian Xin , Han Feifei , Liu Lihong , Gao Jianen , Ma Xu 
Published: October 2019

Objective.SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome is a type of rare chronic aseptic inflammation of unknown etiology. To date, no research to our knowledge has reported copy number variation (CNV) of genes that could affect predisposition to SAPHO syndrome. We investigated the association between CNV profile and SAPHO syndrome.Methods.We used array comparative genomic hybridization (CGH) to screen for CNV in a nuclear family including 2 patients and a healthy control. We then validated the copy numbers of candidate genes found in the array CGH assay and other candidate genes by TaqMan real-time PCR in 360 case and control samples.Results.Ten regions from 8 chromosomes were found to have abnormal gene copies in the nuclear family, so the CNV of candidate genes (ADAM5, CSF2RA, IL3RA, and 9 other genes) were tested by TaqMan PCR. Significant copy number loss of CSF2RA (p = 0.000) and NOD2 (p = 0.005), and significant copy number gain of MEGF6 (p = 0.002) and ADAM5 (p = 0.000) were seen in patients with SAPHO compared with controls at the a = 0.05 level. There were no differences in the other 8 candidate genes between patient and control samples (p > 0.05).Conclusion.Our study established the first association between CNV in CSF2RA, NOD2, MEGF6, and ADAM5 and SAPHO syndrome. These findings may offer insight into the pathogenesis of SAPHO and provide the basis for improved diagnosis and treatment.
Opioid Use among Patients with Early Inflammatory Arthritides Compared to the General Population
Authors: Muilu Paula , Rantalaiho Vappu , Kautiainen Hannu , Virta Lauri Juhani , Puolakka Kari 
Published: October 2019

Objective.To assess to what extent the worldwide opioid epidemic affects Finnish patients with early inflammatory arthritis (IA).Methods.From the nationwide register maintained by the Social Insurance Institution of Finland, we collected all incident adult patients with newly onset seropositive and seronegative rheumatoid arthritis (RA+ and RA–) and undifferentiated arthritis (UA) between 2010 and 2014. For each case, 3 general population (GP) controls were matched according to age, sex, and place of residence. Drug purchases between 2009 and 2015 were evaluated 1 year before and after the index date (date of IA diagnosis), further dividing this time into 3-month periods.Results.A total of 12,115 patients (66% women) were identified. At least 1 opioid purchase was done by 23–27% of the patients 1 year before and 15–20% one year after the index date. Relative risk (RR) of opioid purchases compared to GP was highest during the last 3-month time period before the index date [RR 2.81 (95% CI 2.55–3.09), 3.06 (2.68-3.49), and 4.04 (3.51–4.65) for RA+, RA–, and UA, respectively] but decreased after the index date [RR 1.38 (1.23–1.58), 1.91 (1.63–2.24), and 2.51 (2.15–2.93)]. Up to 4% of the patients were longterm users both before and after the diagnosis.Conclusion.During 2009–15 in Finland, opioid use peaked just before the diagnosis of IA but decreased rapidly after that, suggesting effective disease control, especially in seropositive RA. Further, opioids were used to treat arthritis pain of patients with incident RA and UA less often than previously reported from other countries.
Effect of Secukinumab on the Different GRAPPA-OMERACT Core Domains in Psoriatic Arthritis: A Pooled Analysis of 2049 Patients
Authors: Orbai Ana-Maria , McInnes Iain B. , Coates Laura C. , Husni M. Elaine , Gladman Dafna D. , Gossec Laure , Pricop Luminita , Chambenoit Olivier , Meng Xiangyi , Mease Philip J. 
Published: October 2019

Objective.To compare the efficacy of secukinumab with that of placebo across the updated Group for Research and Assessment of Psoriasis and Psoriatic Arthritis and Outcome Measures in Rheumatology (GRAPPA-OMERACT) individual psoriatic arthritis (PsA) core domains using pooled data from 4 phase III PsA studies and 1 phase III ankylosing spondylitis (AS) study.Methods.Data were pooled from 2049 patients with PsA participating in 4 on-label phase III PsA studies (FUTURE 2–5), and the efficacy of each GRAPPA-OMERACT PsA core domain (musculoskeletal disease activity, skin disease activity, pain, patient’s global assessment, physical function, health-related quality of life, fatigue, and systemic inflammation) was assessed using multiple measures and definitions specific to each domain. The MEASURE 2 study, a phase III clinical trial in patients with AS, was used to assess improvement in spine symptoms at Week 16.Results.Treatment with secukinumab demonstrated robust and consistent efficacy across all GRAPPA-OMERACT PsA core domains, with secukinumab 300 mg showing the greatest response rates across most PsA core domains compared with placebo at Week 16. Notably, among patients treated with secukinumab 300 mg, 34.3% and 19.5% achieved complete resolution of swollen and tender joint counts, respectively; 53.2% and 61.5% achieved complete resolution of enthesitis and dactylitis, respectively; and 33.2% achieved 100% improvement in Psoriasis Area and Severity Index (all p < 0.05 vs placebo); similar improvements were shown for all other core domains.Conclusion.This analysis suggests that secukinumab can benefit people with PsA across the clinical phenotypic spectrum commonly encountered in this disease.
How Systemic Sclerosis Affects Healthcare Use and Complication Rates after Total Hip Arthroplasty
Authors: Singh Jasvinder A. , Cleveland John D. 
Published: October 2019

Objective.To assess whether outcomes after primary total hip arthroplasty (THA) differ in systemic sclerosis (SSc).Methods.We used the 1998–2014 US National Inpatient Sample. THA and SSc were identified using procedure and diagnostic codes, respectively. Multivariable-adjusted logistic regression analyses assessed the association of SSc with in-hospital complications (implant infection, revision, transfusion, mortality) post-THA and associated healthcare use (hospital charges, hospital stay, discharge to non-home setting), adjusting for age, sex, race, Deyo-Charlson comorbidity index, primary diagnosis for THA, household income, and insurance payer.Results.Of the 4,116,485 primary THA performed in the United States in 1998–2014, SSc patients made up 0.06% (n = 2672). In multivariable-adjusted analyses, compared to people without SSc, people with SSc had higher adjusted OR (95% CI) of the following post-primary THA: (1) non-home discharge, 1.25 (95% CI 1.03–1.50); (2) hospital stay > 3 days, 1.61 (95% CI 1.35–1.92); (3) transfusion, 1.54 (95% CI 1.28–1.84); and (4) in-hospital revision, 9.53 (95% CI 6.75–13.46). Differences in in-hospital mortality had a nonsignificant trend [2.19 (95% CI 0.99–4.86)]. There were no differences in total hospital charges or implant infection rates.Conclusion.SSc was associated with a higher rate of in-hospital complications and healthcare use after primary THA. Future studies should examine whether pre- or postoperative interventions can reduce the risk of post-THA complications in people with SSc.
Mirroring learning ecologies of outstanding teachers to integrate ICTs in the classroom
Authors: Romeu-Fontanillas Teresa , Guitert-Catasús Montse , Raffaghelli Juliana-E. , Sangrà Albert 
Published: October 2019

This paper presents an exploratory study to examine the practices of outstanding primary school teachers in their professional development for ICT integration in teaching and learning, as a means of understanding how their learning ecologies develop and function. Outstanding teachers in the context of this study are teachers who innovate pedagogically and who are influential in the community, having successfully developed their learning ecology. Using a qualitative approach, we explore the concept of learning ecologies as a driver for innovation in the professional development of teachers, using a carefully selected sample of nine outstanding teachers. Drawing from in-depth interviews, specific coding and NVIVO analysis, our results show that these teachers develop organized systems for activities, relationships and resource usage and production, which can be characterized as the components of their professional learning ecology, to continuously keep up to date. We also identified some characteristics of teachers that perform outstandingly and factors that potentially facilitate or hinder their learning ecology development. Further research in the field will enable an improved understanding of the professional learning ecologies of school teachers and support future interventions and recommendations for professional development through the cultivation of emerging professional learning ecologies.
Este artículo presenta un estudio exploratorio que examina prácticas de docentes referentes de Educación Primaria en su desarrollo profesional para la integración de las TIC en la docencia y el aprendizaje como medio de comprensión operacional de las ecologías de aprendizaje. Un docente referente en el contexto de este estudio es aquel que innova pedagógicamente y que influye en la comunidad, habiendo desarrollado con éxito su ecología de aprendizaje. Mediante un enfoque cualitativo, se explora el concepto de ecologías de aprendizaje como motor de la innovación en el desarrollo profesional de los docentes, utilizando una muestra cuidadosamente seleccionada de nueve profesores de Educación Primaria. A partir de entrevistas en profundidad, codificación específica y análisis con NVivo, los resultados muestran que estos docentes despliegan sistemas organizados de actividades, relaciones y recursos, que pueden ser caracterizados como componentes de sus ecologías de aprendizaje para mantenerse permanentemente actualizados. Se identifican algunas de las características y factores que potencialmente facilitan u obstaculizan el desarrollo de su ecología de aprendizaje. Futuras investigaciones en esta línea permitirán mejorar la comprensión de las ecologías de aprendizaje profesional de los docentes, apoyando nuevas intervenciones y recomendaciones para el desarrollo profesional.
Self-perception about emerging digital skills in Higher Education students
Authors: León-Pérez Francisco , Bas María-Carmen , Escudero-Nahón Alexandro 
Published: October 2019

The current labor market demands new qualities and knowledge from the recent graduates of universities. This has been called ‘21st century digital skills’ and there is not enough research on the self-perception of students in this regard. The objective of this research was to measure student self-perception about their own 21st century digital skills related to the use of information and communication technologies (ICT) in Higher Education. A questionnaire was generated and applied to 356 students with the stratified random sampling technique. A principal component analysis was carried out, supported by adequate values of the Kaiser-Meyer-Olkin coefficient and the Bartlett sphericity test. The data indicate that the students use digital technology in academic projects, primarily; they have a lot of skill when using ICT for information management, to develop critical thinking and to solve problems, as well as to manage mobile devices. However, their self-perception in the use of ICT in teaching classes is low. The results suggest that the students do not believe that the use of ICT in the classroom is useful to develop this kind of emerging digital skills. Instead, they think that carrying out academic projects does strengthen the acquisition and development of such skills in relation to the use of ICT.
El mercado laboral actual exige nuevas cualidades y conocimientos a los recién egresados de las universidades, incluidas las habilidades digitales, no existiendo suficientes investigaciones sobre la autopercepción del estudiantado al respecto. El objetivo de esta investigación fue medir la percepción que el estudiantado tiene sobre sus propias habilidades digitales del siglo XXI, en relación con el uso de las tecnologías de la comunicación (TIC) en la Educación Superior. Se generó y aplicó un cuestionario a 356 estudiantes con la técnica de muestreo aleatorio estratificado. Se realizó un análisis de componentes principales avalado por valores adecuados del coeficiente Kaiser-Meyer-Olkin y de la prueba de esfericidad de Barlett. Los datos indican que el estudiantado usa la tecnología digital en proyectos académicos primordialmente, y posee alta habilidad al usar las TIC para la gestión de información, para desarrollar pensamiento crítico y para resolver problemas, así como para manejar dispositivos móviles. Sin embargo, su autopercepción es baja respecto al uso de las TIC en la impartición de clases. Los resultados sugieren que el estudiantado no cree que el uso de las TIC en el aula sea útil para desarrollar este tipo de habilidades digitales emergentes. En cambio, indican que la realización de proyectos académicos sí fortalece la adquisición y desarrollo de tales habilidades en relación con el uso de las TIC.
Teaching in the Affective Domain
Authors: Schoenly Lorry 
Published: October 2019

ABSTRACT
Elements of the affective domain encompass receiving, responding, valuing, organization, and characterization by a value or value complex. Nurse educators are taking a renewed look at affective education in light of a desire to prepare humanistic nurses who practice the art of caring. The teaching-learning climate necessary for effective implementation of affective instruction is addressed. Instructional methods including role play, case study, questioning, simulation gaming, values inquiry and values clarification are discussed as they relate to affective education.
Determining Educational Needs of Staff Nurses: An Assessment Tool for Nurse Educators
Authors: Courtemanche Brenda M 
Published: October 2019

ABSTRACT
Nurse educators often require a framework to perform learning needs assessments in the hospital setting. This article presents a tool that can be used by nurse educators to collect data in a setting new to them. The tool, based on principles of adult learning, consists of three sections to reflect the perspectives of the three major stakeholders: nurse manager, staff nurse, and nurse educator. It examines nursing practice issues, orientation, continuing education, certification, and relationships with the multidisciplinary team and community groups.
Cotangent Sums Related to the Riemann Hypothesis for Various Shifts of the Argument
Authors: Maier Helmut , Rassias Michael Th. 
Published: October 2019

AbstractOne of the approaches to the Riemann Hypothesis is the Nyman–Beurling criterion. Cotangent sums play a significant role in this criterion. Here we investigate the values of these cotangent sums for various shifts of the argument.
Infecções fúngicas e bacterianas em portadores de hiv hospitalizados
Authors: Aquino Rafael Lemes de , Sousa Neto Adriana Lemos , Vargas Lorena Silva , Lopes Anaísa Filmiano Andrade , Aganhoto Aline Maria Santos , Teixeira Núbia Fernandes , Silva Suzana Ferreira de Paula , Marra Meirielen Danubia 
Published: October 2019

RESUMOObjetivo: investigar a ocorrência de infecções fúngicas e bacterianas nos pacientes portadores de HIV hospitalizados em um hospital universitário. Método: trata-se de estudo quantitativo, descritivo, retrospectivo, tipo transversal. Coletar-se-ão dados dos pacientes que estiveram internados em um hospital universitário, acometidos por infecção pelo HIV, por meio de pesquisa em prontuários impressos e eletrônicos. Resultados esperados: pretende-se conhecer a frequência de infecções fúngicas e bacterianas, especialmente a tuberculose, que acometem o paciente portador do HIV e a eficiência da hemocultura como diagnóstico de infecções bacterianas e fúngicas invasivas. Descritores: HIV; Coinfecção; Síndrome de Imunodeficiência Adquirida; Infecções Bacterianas; Infecção Hospitalar; Terapia Combinada. ABSTRACT Objective: to investigate the occurrence of fungal and bacterial infections in hospitalized HIV patients in a university hospital. Method: this is a quantitative, descriptive, retrospective, cross-sectional study. Data will be collected from patients who were hospitalized in a university hospital, suffering from HIV infection, through research in printed and electronic medical records. Expected results: we intend to know the frequency of fungal and bacterial infections, especially tuberculosis, that affects the patient with HIV and the efficiency of blood culture as a diagnosis of invasive bacterial and fungal infections. Descriptors: HIV; Coinfection; Acquired Immunodeficiency Syndrome; Bacterial Infections; Hospital Infection; Combined Therapy. RESUMEN Objetivo: investigar La ocurrencia de infecciones fúngicas y bacterianas en los pacientes portadores de VIH hospitalizados en un hospital universitario. Método: se trata de un estudio cuantitativo, descriptivo, retrospectivo, tipo transversal. Se recolectarán los datos de los pacientes que estuvieron internados en un hospital universitario, acometidos por infección por el VIH, por medio de investigaciones en prontuarios impresos y electrónicos. Resultados esperados: se pretende conocer la frecuencia de infecciones fúngicas y bacterianas, especialmente la tuberculosis, que afectan al paciente portador del VIH y la eficiencia de la hemocultura como diagnóstico de infecciones bacterianas y fúngicas invasivas. Descritores: VIH; Coinfección; Síndrome de Inmunodeficiencia Adquirida; Infecciones Bacterianas y Micosis; Infección Hospitalaria; Terapia Combinada.
Applications of the Jack's lemma for the meromorphic functions at the boundary
Authors: Akyel Tugba , Ornek Bulent Nafi 
Published: October 2019

In this paper, a boundary version of the Schwarz lemma for the class $\mathcal{%
N(\alpha )}$ is investigated. For the function $f(z)=\frac{1}{z}%
+a_{0}+a_{1}z+a_{2}z^{2}+...$ defined in the punctured disc $E$ such that $%
f(z)\in \mathcal{N(\alpha )}$, we estimate a modulus of the angular
derivative of the function $\frac{zf^{\prime }(z)}{f(z)}$ at the boundary point $c$
with $\frac{cf^{\prime }(c)}{f(c)}=\frac{1-2\beta }{\beta }$. Moreover,
Schwarz lemma for class $\mathcal{N(\alpha )}$ is given.
Feriby's “Lament for Richard II” and the English Literary History ca. 1400
Authors: Carlson David Richard 
Published: October 2019

Abstract
William Feriby was an historic actor: Richard II's secretary between the “Revenge Parliament” of 1397–98 and the deposition of the king in September 1399; subsequently, a contributor to the deposition proceedings; and, finally, a rebel against Henry IV in January 1400. Feriby was also a literary figure, the author of an historical “Lament for Richard II,” amongst other things, written in a highly mannered style of a sort to indicate an interest on Feriby's part in the purely literary: imagination and form. Though Feriby's prose style is distinctive, he was not the only historic-historiographical figure who manifested an interest in the strictly literary at the same moment, ca. 1400. The writings of Adam Usk, Thomas Favent, the Historia vitae author, and Thomas Brinton—even the deposition proceedings and the documentary record of them (the “Record and Process”)—are comparably (though differently) literary. The relations between Ricardian history and literature can be reconceived, dialectically, by light of such evidence: the literature is historical and historic, but, also, the history itself and historiography are literary.
“Peculiar Circles”: The Fluid Utopia at the Northern Pole in Margaret Cavendish's Blazing World
Authors: Brataas Delilah Bermudez 
Published: October 2019

ABSTRACT
Margaret Cavendish's The Blazing World is her most surprising work and contains characteristics from multiple forms; a reader can find elements of forms Cavendish worked on elsewhere and simultaneously recognize the text as something wholly new and unfathomable. Cavendish strategically located the entry to her utopia in the arctic in a time when the tradition of literary ideal spaces looked toward the heavens in descriptions of celestial worlds that paralleled the discovery of the New World. The farthest north offered her not only an empty landscape but the extreme, stark contrast of the binaries she wished to blur. This article will demonstrate that Cavendish's Blazing World emerges as a utopia that demands fluidity to achieve its ideality. One must move fluidly between limiting binaries to transcend spirit and matter, cold and warmth, and ultimately knowledge and ignorance as the only means to conceive, and thus achieve, utopia.
Comunicación Propia y el Rol de las Mujeres: Una Estrategia de Pervivencia Cultural del Pueblo Sia en el Resguardo Indígena Playita San Francisco, Municipio López de Micay, Costa Pacífica-Cauca-Colombia
Authors: Puama Tobar Héctor Silvio 
Published: October 2019

El artículo evidencia las condiciones desfavorables en que los estudios dedicados a la comunicación propia, género, territorio y educación propia son poco estudiados en nuestro contexto y por lo consiguiente no son visibilizadas nuestras formas de pensar y actuar. De ahí que el objetivo de esta investigación se centre en conocer los temas tratados en estas publicaciones, teniendo en cuenta el desarrollo de las epistemologías propias en relación al territorio, roles de géneros, la educación propias entre otras. Como estrategia metodológica, se hizo una búsqueda de información en bases de datos sociológicos, culturales, y antropológicos. Las principales palabras clave empleadas fueron; mujer y género, comunicación propia, educación propia, territorio, y espiritualidad. Se incluyeron artículos originales, revisiones y monografías, nacionales e internacionales, publicadas entre 1990 y 2005.