bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘For Youth by Youth’: Distributive Leadership in Action With a Youth Codesign Team
Authors: Melro Carolyn M. , Brook Caleb , Martin Reid A. , Roberts Renn A. , Young Sophia , Zalik Savannah J. R. , Ballantyne Clifford T. , Neuman Amanda , Reimer Pamela 
Published: November 2024

ABSTRACTBackgroundIntegrated youth services are an emerging delivery model in Canada that addresses siloed and fragmented youth mental health and other services. Youth engagement is viable for developing integrated youth services when purposefully built. However, it is not always clear how youth are involved in service transformation as decision‐makers, and it requires an exploration of how to work with youth authentically and intentionally in the codesign process.MethodsThis study reflects on the development of HOMEBASE, a network of integrated youth service delivery in Saskatchewan, Canada, and documents the process of actively and authentically engaging with youth through distributive leadership in the codesign process.FindingsYouth are actively and eagerly willing to participate in the codesign process of developing integrated services when there is a shared responsibility, and they are authentically involved and informed within the decision‐making process. This requires time to form trust, build relationships and provide youth with low‐pressure environments to foster healthy debates.ConclusionBy utilizing a distributive leadership approach, the Youth Codesign Team has been engaged in various levels of decision‐making. By following these guiding principles, policymakers, youth development workers and researchers can engage youth in meaningful ways to improve the design and development of integrated care.Patient or Public ContributionFive youths from the HOMEBASE Provincial Youth Co‐Design Team collaborated in writing this article based on their experiences of being engaged at varying levels of decision‐making in a distributive leadership approach to building integrated youth services.
Co‐Creation in Research: Further Reflections From the ‘Co‐Creating Safe Spaces’ Project
Authors: Fitzpatrick Scott J. , Lamb Heather , Oldman Erin , Giugni Melanie , Chakouch Cassandra , Morse Alyssa R. , Gulliver Amelia , Stewart Erin ,   Stride Safe Space and Safe Haven Team, Oni Helen T. , Miller Benn , Edwards Bronwen , Stewart Kelly , Bliokas Vida , Ellis Louise A. , Shand Fiona , Calear Alison L. , Banfield Michelle 
Published: November 2024

ABSTRACTBackgroundApplied research using co‐creation methods is rarely described or evaluated in detail. Practical evidence of co‐creation processes and collaboration effectiveness is needed to better understand its complex and dynamic nature.MethodsUsing a case study design and survey method, we assessed processes of co‐implementation and co‐evaluation grounded in our own experiences from the Co‐Creating Safe Spaces project. We examine these in the context of a published systematic framework designed to improve clarity about co‐creation processes and report on how co‐creation was experienced by collaborative partners.ResultsOur study showed the interconnectedness between co‐implementation and co‐evaluation processes and the importance of aligning research with program processes to ensure it is responsive to emergent local needs and problems. Given relatively low levels of researcher embeddedness across sites, service champions played a pivotal role in data collection. Survey findings indicated strong support for a healthy collaboration with some concerns expressed over individual partner's areas of responsibility and ability to deliver on commitments.ConclusionCo‐creation can be a very robust approach to translational research but is a complex endeavour. Ongoing reflexivity and attention to relational aspects support genuine collaboration and provide a foundation for addressing challenges.Patient or Public ContributionPeople with lived experience of emotional distress and/or suicidal crisis, including researchers from both academic and non‐research backgrounds, service managers, peer workers, carers and advocates, were involved in this research and authored this paper.
Co‐Design of a Facilitated Self‐Management Toolkit for People With Parkinson's Disease
Authors: Davies Nathan , Armstrong Megan , Pigott Jennifer S. , Nimmons Danielle , Read Joy , Gardner Benjamin , Maydon Bev , Schrag Anette , Walters Kate 
Published: November 2024

ABSTRACTBackgroundParkinson's disease is a complex progressive neurodegenerative disease increasing globally. Self‐management interventions have shown promise in improving the quality of life for people with chronic conditions. This paper aims to describe the development processes and the core components of a facilitated self‐management toolkit to support people with Parkinson's disease to self‐manage their condition.MethodsAn iterative co‐design approach was adopted and included the use of systematic reviews, qualitative methods and theory to develop the Live Well with Parkinson's toolkit. A co‐design group was established consisting of people with Parkinson's, family carers and health and social care experts to produce and refine an online self‐management toolkit to be tested in practice. Five co‐design groups were conducted alongside several phases of toolkit development.ResultsAn online self‐management toolkit, called Live Well with Parkinson's, was developed with core aspects such as tailored information to the individual, a well‐being section using an asset‐based approach and problem‐solving skills to create and maintain goals, symptom review and management sections and a tracker of medication, symptoms and activities/actions. A paper‐based alternative version was also created for those who cannot use an online resource. The toolkit is fully manualised and facilitated by six sessions from a ‘supporter’ who is trained in behaviour change techniques. It can be shared with carers and healthcare professionals.ConclusionThe toolkit is a robust and comprehensive approach to self‐management of Parkinson's disease. It is evidenced based, incorporates theory and was developed with people with Parkinson's and experts in the area. The Live Well with Parkinson's toolkit has the potential to be embedded within routine healthcare, aligning with self‐management policies.Patient or Public ContributionAuthor B.M. is our patient and public involvement (PPI) representative and author on this paper. B.M. supports a team of 15 PPI members who have contributed to the development of the toolkit. This involvement has included attending research team and steering group meetings, attending and facilitating co‐designed workshops, reviewing all the toolkit information before approval and supporting with the user testing.
Introducing a new regular feature: Practice‐Based Studies
Authors: Pratchett Tracey , Greenfield Katy 
Published: November 2024

AbstractTracey Pratchett, Regular Feature Editor, outlines the requirements of the new Practice‐Based Studies regular feature (formerly Dissertations into Practice). She discusses why the feature has changed and how it will increase the value of short features, providing a broader remit which will appeal to students, early career professionals and those new to publishing who want to share findings which may affect practice. This article also includes a short vignette from Katy Greenfield discussing the benefits of publishing their outputs from an apprenticeship project.
Influencer Marketing, Narrative Transportation, and Consumer Well‐Being: An Exploration of How Virtual Influencers Impact Followers' Well‐Being
Authors: Jain Ritesh , Schuster Lisa , Luck Edwina , Jin Hyun Seung 
Published: November 2024

ABSTRACTWith recent advancements in technologies such as artificial intelligence and computer‐generated imagery, virtual influencers (VIs) have become prominent branding tools that command high engagement rates. Most extant research explores the marketing outcomes of using VIs in brand campaigns. However, little is known about how interacting with VIs on social media platforms may affect consumers' well‐being. This research takes a comprehensive approach, developing a nuanced understanding of whether (and how) human‐like VIs (HVIs) impact consumers' well‐being. We employ a conceptual development approach drawing on scholarship from influencer marketing, narrative transportation, and consumer well‐being and gather additional support for the conceptual framework from data collected by interviewing 25 followers of HVIs. The conceptual framework proposes that when interacting with influencers' social media posts, followers experience narrative transportation, which positively influences followers' hedonic and eudaimonic well‐being. However, the conceptual framework also proposes that these relationships are moderated by the type of influencer (human vs. virtual) sharing the post. Specifically, we suggest that interactions with HVIs provide followers with enjoyment (hedonic well‐being) and support their self‐acceptance, personal growth, relationships, and autonomy (eudaimonic well‐being). We also provide initial evidence of the favorable marketing outcomes of enhanced well‐being from engagement with HVIs, including contemplation of brand purchase. The study thus advances extant VI literature by proposing a theoretically and empirically informed conceptual model that examines HVIs' influence on consumer well‐being. Also, it contributes to addressing the broader calls for research on the impact of social media and influencer marketing on consumer well‐being.
Formation professionnelle et inadéquation des qualifications: l'exemple de la République de Corée
Authors: HWANG Inyoung , PARK Youngseok , CHOE Chung 
Published: November 2024

RésuméLes auteurs examinent l'impact de la formation professionnelle sur l'inadéquation des qualifications ‐ un sujet peu étudié ‐ dans le contexte de la République de Corée, où cette inadéquation est forte. Ils utilisent des données administratives sur la formation professionnelle (2016‐2019) et un modèle à effets fixes pour analyser les déterminants des taux d'emploi spécifiques (dans le métier ciblé ou les métiers connexes) au lieu de se cantonner au taux d'emploi total. Ils constatent que le nombre d'heures de formation a un impact positif plus grand sur les taux d'emploi spécifiques que sur le taux d'emploi total, tandis que l'inverse est vrai s'agissant des caractéristiques individuelles.
Environmental impact of large language models in medicine
Authors: Kleinig Oliver , Sinhal Shreyans , Khurram Rushan , Gao Christina , Spajic Luke , Zannettino Andrew , Schnitzler Margaret , Guo Christina , Zaman Sarah , Smallbone Harry , Ittimani Mana , Chan Weng Onn , Stretton Brandon , Godber Harry , Chan Justin , Turner Richard C. , Warren Leigh R. , Clarke Jonathan , Sivagangabalan Gopal , Marshall‐Webb Matthew , Moseley Genevieve , Driscoll Simon , Kovoor Pramesh , Chow Clara K. , Luo Yuchen , Thiagalingam Aravinda , Zaka Ammar , Gould Paul , Ramponi Fabio , Gupta Aashray , Kovoor Joshua G. , Bacchi Stephen 
Published: November 2024

AbstractThe environmental impact of large language models (LLMs) in medicine spans carbon emission, water consumption and rare mineral usage. Prior‐generation LLMs, such as GPT‐3, already have concerning environmental impacts. Next‐generation LLMs, such as GPT‐4, are more energy intensive and used frequently, posing potentially significant environmental harms. We propose a five‐step pathway for clinical researchers to minimise the environmental impact of the natural language algorithms they create.
Multiple Treatment Strategies of Accessory Renal Artery Related Hypertension: Report of Two Cases and Literature Review
Authors: Wang Lin , Xie Yiyun , Kong Deqiang , Li Kang , Lai Zhichao , Shao Jiang , Zeng Rong , Di Xiao , Ni Leng , Zheng Yuehong , Liu Bao 
Published: November 2024

ABSTRACTRenovascular hypertension (RVH) is a primary cause of secondary hypertension, primarily driven by the activation of the renin–angiotensin–aldosterone system activation. Recently, growing studies suggested accessory renal artery (ARA) might also contribute to RVH. However, the treatment of ARA‐related hypertension and whether to take interventional treatment lack consensus. Herein, we report two cases of ARA‐related hypertension in our hospital. Imaging studies of both patients showed ARA stenosis. One patient had ARA occlusion well‐compensated through tortuous collateral branches, achieving normal blood pressure by medical treatment alone. The other patient had ARA stenosis coexisted with main renal artery stenosis, and revascularization of both arteries led to a significant postoperative reduction in blood pressure. A literature review was conducted to summarize overall treatment strategies for ARA‐related hypertension and clarify the relationship between ARA and hypertension. Recent research supported an association between ARA and hypertension. While medical therapy remains the first‐line treatment for ARA‐related hypertension, interventional procedures should be considered for patients whose blood pressure remains uncontrolled despite conservative management.
Repurposing flubendazole for glioblastoma ferroptosis by affecting xCT and TFRC proteins
Authors: Teng Wei , Ling Yuanguo , Long Niya , Cen Wu , Zhang Hongzhi , Jiang Lishi , Liu Jian , Zhou Xingwang , Chu Liangzhao 
Published: November 2024

AbstractNew uses of old drugs hold great promise for clinical translation. Flubendazole, an FDA‐approved antiparasitic drug, has been shown to target p53 and promote apoptosis in glioblastoma (GBM) cells. However, its damaging mechanism in GBM remains elusive. Herein, we explored the ferroptosis‐inducing ability of flubendazole on GBM cells. After treating glioma cell lines U251 and LN229 with the flubendazole (DMSO <1‰), cell viability was inhibited in a concentration‐dependent manner (IC50 for LN229 = 0.5331 μM, IC50 for U251 = 0.6809 μM), attributed to the induction of ferroptosis, as evidenced by increased MDA levels, accumulation of ROS and lipid peroxides, change in mitochondrial membrane potential and structure. Protein analysis related to ferroptosis showed upregulation of TFRC, DMT1 and p53, alongside downregulation of xCT, FHC and GPX4 (p < 0.05). All‐atom docking studies demonstrated that flubendazole bound closely with xCT, and TFRC, validating its role in inducing glioma ferroptosis via modulation of these proteins. Notably, flubendazole could damage the glioblastoma stem cells (GSC) that are typically resistant to other therapies, thereby possessing advantages in stopping glioma recurrence. This study delved into the mechanisms of flubendazole‐induced ferroptosis in glioma, broadening its application and providing new ideas for new uses of other old drugs.
Modelling and Optimizing the Integrity of an Automated Vegetable Leaf Packaging Machine
Authors: Ojo Oluwole Timothy , Ayodeji Sesan Peter , Azeez Nurudeen Akanji 
Published: November 2024

ABSTRACTThis study emphasized the need for postharvest technology in Nigeria's vegetable production to reduce postharvest losses ranging from 5% to 50%, focusing on enhancing processes of automated packaging unit of vegetable processing plant through the use of artificial neural networks (ANN). The experiment was conducted on a vegetable leaf processing plant with the objective of improving the reliability and performance of the automated packaging unit. Operating parameters such as moisture contents, leave particle size, time taken, throughput capacity, and specific mechanical energy consumption were varied to determine the optimum condition for each parameter. Statistical analysis was performed using R software. The appropriate model was chosen based on selection of the highest coefficient of prediction where the additional terms are significant and the model was not aliased, insignificant lack of fit and the maximization of the “Adjusted R2 value” and the “Predicted R2 value.” An optimum packaging condition was obtained at 15% moisture content, and 104.4 particle sizes which gave an optimum packaging time of 0.02 h, optimum packaging capacity of 57.31 kg/h, optimum SMEC value of 0.008 kw/h/kg, optimum repeatability value of 0.128 kg, optimum linearity value of 4.713 cm, optimum accuracy value of 5.2 cm (±0.45). The performance of the ANN model was evaluated using various measures such as mean squared error (MSE), the coefficient of determination (R2), mean absolute error (MAE), and the adjusted R‐squared (Adj. R2) for packaging machine. The results of this study suggest that ANN can be used to effectively optimize packaging units of the vegetable leaf processing plant.
Large‐scale genome‐wide association studies identified causal relationship between multiple blood biomarkers and risk of acute pancreatitis
Authors: Zhang Wenhui , Zhao Yu , Zhang Tao , Lyu Shaocheng , Lang Ren , Jiang Tao 
Published: November 2024

AbstractBackground and AimObservational studies have shown that there is a connection between blood biomarkers and the occurrence of acute pancreatitis (AP). Nevertheless, the causal relationships are still not clear. The purpose of this study was to evaluate causal association between biomarkers and AP.Method(s)A bidirectional two‐sample Mendelian randomization (MR) analysis was applied to investigate the causal association between blood biomarkers and AP. Summary statistics obtained from genome‐wide association studies were utilized for this analysis. The primary statistical approach employed was the inverse variance weighted (IVW) method, complemented by sensitivity analyses aimed at assessing heterogeneity and pleiotropy. Furthermore, a multivariable MR (MVMR) analysis was performed to adjust for confounders.ResultsA total of 11 red blood cell (RBC) traits, 6 white blood cell traits, platelet count, and 30 blood biomarkers were analyzed in this study. Genetically predicted RBC count (IVW odds ratio [OR] = 1.144, P = 0.004), the high light scatter reticulocyte count (HLSR) (OR = 1.127, P = 0.022), blood glucose (BG) (OR = 1.480, P = 0.019), and leptin (OR = 1.234, P = 0.050) were suggestively associated with an increased risk of AP. Reverse MR analysis showed no causal effect of AP on RBC, HLSR, BG, and leptin (IVW P > 0.05). Sensitivity analyses and MVMR analysis still supported the earlier causality.Conclusion(s)Our findings provide evidence of a suggestive association between RBC count, HLSR, BG, and leptin with an increased susceptibility to AP. These findings aid in our comprehension of the cause of AP and may be used as potential prognostic markers or predictors of severity with AP.
The evidence for probiotics in the treatment of digestive disorders in the pediatric population
Authors: Gwee Kok‐Ann , Lee Wei Ren Warren , Chua QiQi , Chiou Fang Kuan , Aw Marion M. , Koh Yu Han 
Published: November 2024

AbstractHealth claims for many probiotic‐labeled products are poorly substantiated. This technical review addressed the clinical question: “Do probiotics have a role in the management of the following conditions in childhood?” Evidence supports efficacy for probiotic strains of Saccharomyces boulardii, Lactobacillus reuteri, and Lactobacillus rhamnosus GG for improving outcomes of acute gastroenteritis, of S. boulardii and L. rhamnosus GG for antibiotic‐associated diarrhea, and of S. boulardii for Clostridium difficile diarrhea. For functional constipation and GERD, a role for probiotics is questionable as evidence of efficacy is either absent or marginal and as existing treatments are effective. For infantile colic and chronic abdominal pain, where existing treatments have limited efficacy and some important side effects, the use of probiotics, given their safety, is recommended, notwithstanding the evidence is low to moderate. While there is some evidence that probiotics could improve outcomes in the management of celiac disease, obesity, and, to a lesser extent, promotion of growth, their role is adjunctive as dietary management is fundamental. The evidence also supports an adjunctive role for probiotics in the treatment of Helicobacter pylori infection and ulcerative colitis. Decisions on probiotic prescription need to take into account disease tempo, severity, and burden, as well as probiotic strain and dose. Any potential advantage will have to be weighed against the complexity and costs of an additional treatment.
Synchronous Pleural and Peritoneal Mesothelioma in a Free‐Ranging Capuchin Monkey (Sapajus libidinosus)
Authors: de Macêdo Isabel Luana , de Sousa Davi Emanuel Ribeiro , da Fonseca Yasmin Nunes Godoy , Cerqueira Liz de Albuquerque , de Sousa Ana Lívia Vasconcelos , de Melo Cristiano Barros , Mendes de Lima Eduardo Mauricio , de Castro Márcio Botelho 
Published: November 2024

ABSTRACTA free‐ranging capuchin monkey developed a synchronous biphasic pleural and peritoneal mesothelioma, a rare form of this tumor. Exophytic nodules were dispersed over the serosal surfaces, showing marked microscopical malignant features composed of both epithelioid and spindeloid neoplastic cells immunopositive for Pan‐Cytokeratin, Cytokeratin 5/6, Vimentin, WT‐1, and D2‐40.
Microfocused Ultrasound With Visualization Induces Remodeling of Collagen and Elastin Within the Skin
Authors: Marquardt Kay , Hartmann Christian , Wegener Flora , Park Je‐Young , Halbert Douglas , Hsu Stephen , Hengl Thomas 
Published: November 2024

ABSTRACTPurposeMicrofocused ultrasound with real‐time visualization (MFU‐V) is often used for noninvasive skin lifting, by precisely targeting dermal and subcutaneous tissues to create thermal coagulation points (TCPs). These TCPs denature collagen and initiate a transient inflammatory response, ultimately attracting dermal fibroblasts and inducing efficient neocollagenesis and extracellular matrix (ECM) remodeling, yielding to MFU‐V's desired skin‐lifting effects. The current study investigates MFU‐V's underlying mode of action based on the histological progression of TCPs in the skin, providing new insight into the technology's regenerative effect.MethodsFollowing standard triple‐depth MFU‐V treatment, in vivo skin samples were assessed using histology and immunohistochemistry to evaluate TCPs, heat shock protein (HSP47), and elastin expression in fibroblasts.ResultsMFU‐V treatment induced elongated, flame‐like TCPs with denatured collagen at focal depths of 1.5, 3.0, and 4.5 mm within the skin—each corresponding to its respective transducer depth. Time‐dependent progression of TCPs showed significantly increased scores of fibroblasts and mature collagen along with recruitment of HSP47‐positive fibroblasts to TCP areas on Day 90. Collagen formation and later maturation were visualized. Newly synthesized elastin significantly increased in the TCP area on Day 90 compared to Day 14.ConclusionThis work provides histological evidence of stimulation and regeneration of newly synthesized elastin fibers after TCP induction. MFU‐V‐generated TCPs triggered the body's own healing cascade of collagen denaturation, transient inflammation, proliferation, and tissue remodeling, resulting in attraction of HSP47‐positive fibroblasts to the TCP sites, and new collagen and elastin fiber regeneration by fibroblasts. Besides the well‐described neocollagenesis, this study demonstrates that MFU‐V treatment induces elastin neogenesis that may result not only in skin lifting but also in improved skin elasticity, providing an overall regenerative effect.