bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison analysis of Baso Cellular Carcinoma and Spino Cellular Carcinoma - Protein Kinase D1, Wnt/β-catenin and Epithelial to Mesenchimal Transition (markers)
Authors: Ivanova Petya V. , Maneva Ana I. 
Published: March 2018

Understanding cancer biology is crucial to the successful diagnosis and application of personalized therapies. Skin carcinogenesis is a multi-step process. The first step is the development of potentially malignant disorders (PMDs) known as leukoplakia, erytroplakia, lichen planus, probably trough mutation in the proteins regulated cell cycle (p16INK4A, p21Waf1/Cip1/Sdi1, p27 kip1, Cyclin D1) and, second in p53 (TP53), Ras, hTert, EGFR, will reverse benign phenotype of late precancer lesions (PMDs) into benign cancer lesion. Third mutation probably in PI3K, PKD1 or E-cadherin, will increase malignant potential of SCCs, activating EMTransition, invasion and metastasis, e.g. aggressive phenotype. In BCC mutations of p53 are known to be late events (UV signature), whereas silencing of 14-3-3 takes place early in tumor progression, concomitant with increased activity of Snail. Early increased expression of PKD1 and down-regulation of c-myc mRNA are also events in pathogenesis of BCC. There is no data for detected mutations in PKD1 gene in both cancers, although the kinases is with high expression in BCC and lack of expression in SCC. There is no data concerning PKD1 expression in the PMDs leading to SCCs, nor to BCCs, such data were recently published concerning PKD1 expression in pancreatic oncogenesis. Curently adequate question is whether lack of PKD1 expression in SCCs, despite its PMDs origin, is a consequence of its spinous layer origin, or is a consequense of PKD1 gene mutations (downregulation). Identification of mutations as markers for early malignant transformation could be useful for early diagnosis and treatment of skin head and neck cancers.
Jamesonian Interpretation of Post Postmodernism: David Foster Wallace’s Infinite Jest and The Pale King
Authors: Goudarzi Abdolreza 
Published: March 2018

Postmodernism and Post Postmodernism have dominated culture and literature since the late-20th-century and in basic features, they contradict each other. In Postmodernism, or the period known as the late capitalism by Fredric Jameson, some sort of fragmentation rather than totality is intended to control again the life of the people through the same media in a process known as consumerism; However, in Post Postmodernism, a new sort of humanism seems to be emerging by David Foster Wallace who shows not only the pain but also the cure. In fact, the subjectivity of man is given a niche, and also he is given a voice to express his thought, like the opportunity he has gained in the social networks like Facebook and Telegram, having made it paradoxically possible for him to have a sort of sharing among the fragmented individuals. In fact, every fragmented man can be an active agent, communicator, and finally a producer to bring meaning and discipline back to the life rather than a sole passive watcher, reader, and one way communicator controlled by the system as presented in the modern and postmodern works. Focusing on David Foster Wallace’s (1962-2008) novels—Infinite Jest (1996) and The Pale King (2011), the aim of this article is to study these three novels through the critical gates of the philosopher, Fredric Jameson to open up the concepts of Post Postmodernism.
Glycemic Index for Sucrose, Corn Syrup and Honey Entrained Highbush Cranberry Juice
Authors: Soylu Meltem 
Published: March 2018

Glycemic Index (GI) is a measure of the effect foods have on blood glucose (i.e., blood sugar). In this study, it was aimed to find out the GI of highbush cranberry juice (HCJ) in four forms of use (juice with no added sugar and juice sweetened with corn syrup, sucrose or honey) based on data from a total of 20 healthy volunteers.
After not eating for 12 hours and consuming the test foods and the reference food, the participants were subject to blood drawing by automatic lancet, 15, 30, 45, 60, 90, and 120 minutes into the application. GI values of HCJ samples were found by calculating incremental areas for each individual. GI of HCJ with no added sugar had the lowest value (40.95), followed by that of the sucrose added HCJ (42.75). GIs of HCJ with corn syrup and honey were found to be similar, 54.16 and 56.98, respectively. Moreover, those with no added sugar and those with sucrose and corn syrup fell into the low GI category, while the GI of HCJ with honey fell into the medium GI category. In conclusion, it is suggested that consuming HCJ with low GI values might be a healthier choice for individuals with chronical illnesses.
Keywords: Glycemic index, highbush cranberry juice, sucrose, corn syrup, honey.
The Influence of Leadership Style, Work Environment on Job Satisfaction and Employee Performance at PT. Khrisna Multi Lintas Cemerlang
Authors: Kusumadewi Ni Putu Rista , Sudja I Nengah , Sujana I Wayan 
Published: March 2018

This study aims to examine and analyze the relationship between leadership style, work environment, job satisfaction and employee performance. This research was conducted at PT. Khrisna Multi Lintas Cemerlang with the research population were all employees who work in the company. All data obtained from questionnaires were suitable for use, then were analyzed by using structural equation model based on variant analysis which is known as Partial Least Square (PLS).
The result of this research shows that the leadership style has positive and significant effect on employee performance, the work environment has positive and significant effect on employee performance, the leadership style has positive and significant effect on job satisfaction, the work environment has positive and significant effect on job satisfaction and job satisfaction has positive and significant on employee performance.
The implication of this research was that the leadership needs to give freedom to subordinate to express their opinions, the workplace air temperature was well regulated, the work that was charged according to the ability and expertise, always guided by the company standard in carrying out each task and the employee has high knowledge in solving problem
Effect of Compensation and Work Environment on Employee Performance with Employee Job Satisfaction as an Intervening Variable
Authors: Juliarti Putu Ayu Diah , Agung Anak Agung Putu , Sudja I Nengah 
Published: March 2018

An employee who has a high performance and better able to support the achievement of the goals and objectives set by the company. Employees can work well if you have a high performance that can produce good work anyway. With the high- performance that employees, is expected to achieve organizational goals.
This study examines the effect of compensation and work environment on employee performance with job satisfaction to be intervening variable. Data on compensation, work environment, job satisfaction, and employee performance obtained through observation, record keeping and questioner with respondents. The data obtained are then analyzed using Partial Least Squares (PLS).
Statistical tests results showed (1) the compensation proved significant positive effect on job satisfaction the path coefficient of 0.434 and T-Stats for 4.880, (2) work environment proved to be a significant positive effect on job satisfaction the path coefficient of 0.434 and T-Stats for 4.074, (3) job satisfaction proved to be a significant positive effect on employee performance the path coefficient of 0.264 and T-Stats for 2.458, (4) compensation proved positive and significant effect employee performance the path coefficient of 0.242 and T-Stats for 2.912, (5) work environment proved positive and significant effect employee performance the path coefficient of 0.378 and T-Stats for 3.343. Based on test results obtained statistical results of all variables positive and signicant impact.
The Role of Organizational Commitment to Provide Leadership and Organizational Culture with Employee Performance on Mina Group
Authors: Jaya Utama I Gusti Ngurah Mandala , Sapta I Ketut Setia , Yuesti Anik 
Published: March 2018

This study aims to improve and control the relationship between leadership, organizational culture, organizational commitment and employee performance. This research was conducted at Warung Mina Group with Warung Mina Group employee population, 81 respondents sampled by stratified random sampling method. All data generated from questionnaires are suitable for use, and then analyzed using the structural equation model called Partial Least Square (PLS).
The result of the research shows (1) positive leadership leadership and significant to organizational commitment, (2) organizational culture have positive and significant influence to organizational commitment, (3) positive leadership leadership and significant to employee performance, (4) organizational culture have positive and significant impact to employee performance and.
The implications of this research are that leadership can be maximized by motivational excellence, organizational culture can be improved by applying emphasis on the group (emphasis group), organizational commitment is maximized by increasing affective application and improved employee performance by maximizing the quantity of work.
The Effect of Job Characteristics and Compensation to Work Satisfaction and Organization Commitment on All Lpd Kerambitan Tabanan
Authors: Putra Bagus Nyoman Kusuma , Sudja I Nengah , Martini Luh Kadek Budi 
Published: March 2018

Job characteristics are the nature of the task that includes the responsibilities, tasks and levels of satisfaction derived from the work itself. Compensation is something that employees receive in exchange for the contribution of their services to the organization. Job satisfaction is a set of employee feelings about the fun or the absence of their work. Organizational commitment is a desire or encouragement from within an individual to take an active role in making endeavors to realize organizational goals.
The purpose of this study is to examine the effect of job characteristics and compensation on job satisfaction and organizational commitment on LPD staffs of the Kerambitan, Tabanan. The sampling technique used is proportional random sampling. The sample in this research is 86 employees in all LPD Kerambitan Tabanan. Data analyst method used is SEM analysis (Structural Equation Modeling) based on component or variance that is PLS (Partial Least Square). The result of research indicate that job characteristic and compensation variable have positive effect to job satisfaction. Job characteristics do not affect organizational commitment, while compensation has a positive effect on organizational commitment either partially or through job satisfaction. Job satisfaction has a positive effect on organizational commitment.
Down regulation of COX-2, IL-1β, TNF-α in cynoviocyte by essential oil of Fraxinus excelsior
Authors: Hossein Dr Maghsoudi, , Haj-allahyari Samaneh 
Published: March 2018

Osteoarthritis (arthritis) is biomechanical, biochemical and cellular phenomenon, and is not known as a degenerative disease. Arthritis is one of the common chronic diseases and the most important reason of physical disability in the world. According to its side effect such as peptic ulcers, gastrointestinal bleeding, liver toxicity and renal complications dueofprescribing current treatment contain corticosteroid and non-steroidal, we decided to evaluate possible effect of anti-inflammatory Esential oil of Fraxinus excelsior (EOFE) on biomarkers involved in disease. EOFE were prepared of genetic resources center. Bovine articular cartilage derived from the metacarpophalangeal joints of 14–18-month-old animals (without any sign of inflammation and bleeding) sent to laboratory in sterile bags at 4ºC. Cells were cultured in appropriate condition and counted by hemocytometer, viability assessed by trypan blue. After LPS treatment, cytokine levels were assayed. Cells cultures again and were kept in 37C, 90% humidity in CO2 incubator and after RNA extraction, RT-PCR and PCR done. Also by Real-time PCR, gene expression was evaluated. E.E.F.E level cause down regulation of COX-2, IL-1β, TNF-α in LPS-stimulated cells.
A cerebralis amyloid angiopathia radiológiai megjelenési formái
Authors: Csizmadia Sándor , Vörös Erika 
Published: March 2018

Abstract: Cerebral amyloid angiopathy (CAA) is most commonly recognized by β-amyloid deposition in the small and medium sized vessels of the brain. The 71-year-old female presented with a sudden onset of vertigo and headache. By native computer tomography (CT) examination we found cerebral atrophy and the sign of chronic vascular injury. The complaints of the patient worsened, thus magnetic resonance imaging (MRI) was performed. The MRI scan revealed a bleeding transformation of an ischemic lesion in the right occipital region. On the susceptibility weighted scans we could observe old microbleedings, thus we suspected CAA. The patient later re-presented at the clinic with a sudden onset of right sided hemiplegia. We performed a native CT scan which identified cerebral hemorrhage in atypical position confirming our diagnosis. CAA has many radiological presentations. The most important is the lobar cerebral hemorrhage. On the susceptibility weighted MRI scans, we could identify the microbleeds and the superficial siderosis by the deposition of the hemosiderin. The subarachnoid hemorrhage is a sign of bad outcome. In the white matter, we could detect the change of the related inflammation and the leukoaraiosis. Further, two not specific abnormalities can be important as well, such as extended ischemic lesions and perivascular space dilatation. CAA has various appearances on MRI. Repeated vascular events and dementia in old age patients draw attention to its presence. The correct diagnosis can be made with the right interpretation of the patient’s complaints in combination with the radiological abnormalities. Orv Hetil. 2018; 159(11): 439–444.
Második emlőmegtartó műtét és szövetközi sugárkezelés az emlődaganat lokális kiújulásának kezelésére. Ötéves eredmények
Authors: Smanykó Viktor , Mészáros Norbert , Újhelyi Mihály , Fröhlich Georgina , Stelczer Gábor , Major Tibor , Mátrai Zoltán , Polgár Csaba 
Published: March 2018

Abstract: Introduction and aim: To report the clinical outcomes of second breast-conserving therapy with perioperative interstitial radiotherapy for the treatment of ipsilateral breast tumor recurrences. Method: Between 1999 and 2015, 33 patients, presenting with an ipsilateral breast tumor recurrence after previous breast conserving therapy, were salvaged by re-excision and perioperative high-dose-rate interstitial brachytherapy. A median of 8 (range: 4–24) catheters were implanted into the tumor bed intraoperatively. A total dose of 22 Gy in 5 fractions of 4.4 Gy was delivered to the tumor bed with a margin of 1–2 cm, on 3 consecutive days. The adjuvant systemic treatments consisted of hormonal therapy for 24 patients (73%) and chemotherapy for 6 patients (18%). The survival results were estimated by the Kaplan–Meier method. Late side effects and cosmetic results were also registered. Results: The median follow-up time following the second breast conserving therapy was 61 months (range: 26–189 months). During the follow-up, 4 patients (12.1%) developed second local recurrence. The five-year actuarial rates of the second local, regional and distant recurrence were 6.3%, 6.1%, and 14.9%, respectively. The five-year probabilities of disease-free, cancer-specific and overall survival were 76.2%, 92.4%, and 89.2%, respectively. Four (12%), 19 (58%), 4 (12%) and 6 (18%) patients had excellent, good, fair and poor cosmetic results, respectively. Grade 2 and 3 fibrosis developed in 9 (27%) and 1 (3%) patients. Asymptomatic fat necrosis was detected in 7 (21%) women. Conclusion: Second breast conserving therapy with perioperative high-dose-rate interstitial brachytherapy is a safe and feasible option for the management of ipsilateral breast tumor recurrences. Interstitial brachytherapy may decrease the risk of second local relapse with acceptable cosmetic results and low rate of late side effects. Hence, in selected cases it can provide a feasible alternative to salvage mastectomy. Orv Hetil. 2018; 159(11): 430–438.
A kiskorú páciensek jogainak helyzete az erdélyi egészségügyi ellátásban
Authors: Albert-Lőrincz Csanád 
Published: March 2018

Abstract: This study summarizes the results of the author’s PhD thesis presenting the research process and the most important findings regarding the situation of Transylvanian healthcare. Our data are based on the knowledge and compliance of pediatric patients’ rights as they are seen by healthcare specialists, parents and children. A number of 751 persons were involved in the research: 200 healthcare specialists, 200 parents, 200 children aged from 7 to 17 years who have been experiencing health services at least three times over the past year and a control group of 151 children who did not have this kind of experience. Based on our data, it was possible to highlight the major problems encountered in children’s healthcare. We found that children are treated by obsolete principles of medical practice despite the fact that the rights of pediatric patients are well known to doctors. Neither the parents nor the children themselves are sufficiently aware of their rights. Healthcare professionals are not prepared to overcome communication difficulties due to the age-specific characteristics of children, so the fundamental rights of children are just partially enforced: children are usually heard, but not properly informed, their medical decisions are usually not taken into account violating the right to self-determination. The chances to access adequate health services are lower for vulnerable children living in poverty. Orv Hetil. 2018; 159(11): 423–429.
Az odontogén góc és a szisztémás betegségek. Irodalmi áttekintés
Authors: Párkányi László , Vályi Péter , Nagy Katalin , Fráter Márk 
Published: March 2018

Abstract: The aim of the present review is to provide an up-to-date picture of what we know about the connection between odontogenic foci and non-oral diseases. After a brief historical summary, we give an overview on how the odontogenic focus causes disease in distant areas of the body in general, and then we start the discussion of the particular conditions, such as cardiovascular diseases, pneumonia, diabetes mellitus, metabolic syndrome, rheumatoid arthritis and adverse pregnancy outcomes. The review is centered around the two main odontogenic foci: periodontitis and periapical periodontitis, the latter being a widely recognized but rarely discussed oral focus. Finally, we offer a few considerations that the practicing dentist may find useful when dealing with odontogenic foci. Orv Hetil. 2018; 159(11): 415–422.
Mısırda körpe koçan verim ve özelliklerine hasat zamanlarının etkisi
Authors: KARA Burhan , BOZKURT Havva 
Published: March 2018

Araştırma;
atdişi ve şeker mısırda körpe koçan verimi ve körpe koçan özelliklerine hasat
zamanlarının etkisini araştırmak amacıyla 2015 ve 2016 yıllarında Isparta
koşullarında yürütülmüştür. Körpe mısırlar koçan püskülünün çıkışından
itibaren, 2, 4, 6 ve 8. günde hasat edilmiştir. Deneme;
“Bora” F1 Atdişi ve “Merit” F1 şeker mısır çeşitleri kullanılarak, tesadüf bloklarında faktöriyel deneme desenine göre 3 tekerrürlü
olarak kurulmuştur.
Atdişi ve şeker mısırın dekara körpe koçan sayısı dışında kuru madde oranı,
körpe koçan verim ve özelliklerine hasat zamanlarının etkisi istatistiksel
olarak önemli olmuştur. Genel olarak incelenen karakterler bakımından atdişi
mısır çeşidinin körpe koçan özellikleri şeker mısır çeşidinden daha yüksek
olmuştur. Hasat zamanları geciktikçe her iki mısır çeşidinde de incelenen
karakterlerin değerleri yükselmiştir. 2015 ve 2016 yıllarında, körpe mısır
koçan sayısı, kuru madde oranı, körpe koçan boyu, çapı, ağırlığı ve verimi
sırasıyla, 8086.4-8457.9 adet da-1, %10.91-16.21,
9.07-16.16 cm, 11.04-18.13 mm, 16.31-43.58 g,
130.54-266.69 kg da-1 arasında ölçülmüştür. Her iki çeşitte de koçan püskülü çıkışından
itibaren 2 ile 4 gün arasında hasat yapılması önerilmektedir.
Manisa koşullarında farklı sulama programlarının sofralık üzümde verim, verim bileşenleri ve su kullanım randımanına etkileri
Authors: CEYLAN Hasan , DAĞDELEN Necdet 
Published: March 2018

Manisa Alaşehir Ovasında 2016 yılında, sofralık
çekirdeksiz üzüm çeşidi kullanılarak yapılan bu araştırmada, damla sulama
sistemi ile uygulanan tam ve kısıntılı sulama programlarının yaş üzüm verimi ve
kalitesi üzerine etkileri incelenmiştir. Deneme, tesadüf blokları deneme
desenine göre üç tekerrürlü olarak kurulmuştur. Denemede iki farklı bitki
gelişme dönemi (sürme-çiçeklenme dönemi; çiçeklenme-ben düşme dönemi) dikkate
alınarak 8 farklı sulama konusu incelenmiştir. Etkili kök bölgesindeki (0-90
cm) nem açığı dikkate alınarak sulama konuları oluşturulmuştur. Çalışmanın
sonucunda, farklı sulama konularının, yaş üzüm verimi ve kaliteleri üzerinde
p&lt;0.01 düzeyinde önemli olduğu belirlenmiştir. En yüksek verim değeri gelişme
dönemi boyunca, tam sulama suyu uygulanan S1 konusundan
3960 kg da-1 olarak elde edilmiştir. Sulama konularına
toplamda 13 sulama uygulaması yapılmıştır. En yüksek verimin elde edildiği S1
konusuna toplam 554.8 mm sulama suyu uygulanmış ve mevsimlik bitki su tüketimi
616.2 mm olarak belirlenmiştir. Sürme-çiçeklenme dönemi için verim tepki
etmeni (ky) 1.21 olarak belirlenirken, çiçeklenme-ben düşme dönemi için 0.85
olarak belirlenmiştir. Mevsimlik ky ise 1.04 olarak tespit edilmiştir. Su
kullanım randımanı (WUE) değerlerinin 5.91-10.68 kg m-3,
sulama suyu kullanım randımanı (IWUE) değerlerinin ise 6.51-9.72 kg m-3
arasında değiştiği görülmüştür. Sonuç olarak, yüksek yaş üzüm verimi ve
kaliteli meyve elde etmek için yetişme mevsimi boyunca sulama suyu ihtiyacının
tam karşılanması (S1 konusu) gerektiği, eğer bölgede su kaynağı kısıtlı
ise bu koşulda da sadece %25 düzeyinde su kısıntısı uygulanan S2
konusunun uygun olacağı sonucuna varılmıştır.
Recuperação de nascentes: Formação de multiplicadores ambientais em área degradada de Assentamento rural, Eldorados dos Carajás, Pará
Authors: Barros Ariel Medrado , Chaves Camila De Oliveira , Pereira Gleidson Marques 
Published: March 2018

No sudeste paraense, as frentes agropecuárias e mineradoras quando inseridas na base produtiva do estado, potencializaram a exploração dos recursos naturais disponíveis na região, o que elevou os níveis de degradação ambiental. Desta forma, objetivou-se recuperar nascentes degradadas e a identificar mudanças na percepção ambiental dos produtores rurais do Projeto de Assentamento 17 de Abril, Eldorado dos Carajás, Pará. O trabalho foi desenvolvido em cinco propriedades, as quais suas nascentes foram selecionadas a partir de explanações e debates relacionados ao processo de recuperação ambiental. A área ao entorno de cada nascente foi caracterizada através dos seguintes parâmetros: predominância de cobertura vegetal; ocorrência de processos erosivos no solo; uso de agrotóxicos; presença de animais de criação; evidências de queimadas ou de corte da vegetação; e ocorrência de edificações domésticas e/ ou rurais. A técnica de recuperação e preservação de nascentes utilizada foi a solo-cimento. Um questionário foi aplicado aos proprietários dos lotes com a finalidade de compreender a dinâmica e cultura local e a de que forma a recuperação da nascente modificou ou possa vir a modificá-las. Os resultados apontam o envolvimento dos agricultores e seus familiares com o trabalho executado. A técnica de recuperação e conservação das nascentes foi concebível, visto que, aliado ao isolamento, apresenta eficiência na vedação, o que evita a contaminação da água. Ocorreram mudanças na percepção ambiental dos agricultores, além de melhorias socioambientais.