bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking COPD epidemiology with pediatric asthma care: Implications for the patient and the physician
Authors: Melén Erik , Guerra Stefano , Hallberg Jenny , Jarvis Deborah , Stanojevic Sanja 
Published: April 2019

AbstractWhat are the implications of a lower than expected forced expiratory volume in one second (FEV1) in childhood on respiratory health later in adulthood? Lung function is known to track with age, and there is evidence from recent epidemiologic studies that impaired lung function early in life is associated with later chronic airflow limitation, or even chronic obstructive pulmonary disease, COPD. This risk seems particularly strong in subjects with persistent and severe forms of childhood asthma. Can we translate findings from longitudinal cohort studies to individual risk predictions and preventive guidelines in our pediatric care? In this review, we discuss the clinical implementations of recent epidemiological respiratory studies and the importance of preserved lung health across the life course. Also, we evaluate available clinical tools, primarily lung function measures, and profiles of risk factors, including biomarkers, that may help identifying children at risk of chronic airway disease in adulthood. We conclude that translating population level results to the individual patient in the pediatric care setting is not straight forward, and that there is a need for studies specifically designed to evaluate performance of prediction of risk profiles for long‐term sequelae of childhood asthma and lung function impairment.
Pediatric dermatology and climate change: An argument for the pediatric subspecialist as public health advocate
Authors: Schachtel April , Boos Markus D. 
Published: April 2019

AbstractThe October 2018 report from the United Nations Intergovernmental Panel on Climate Change predicts significant threats to human health secondary to anthropogenic global warming; children have been and will continue to be disproportionately affected by these weather‐related changes. Multiple physician groups have acknowledged climate change as a public health issue, calling upon providers to educate their communities about this looming health crisis while also reducing their individual carbon footprints. A significant body of literature has also documented the adverse dermatologic consequences of a warmer planet, highlighting the importance of pediatric dermatologists in addressing climate change. Here, we summarize the rationale for the pediatric dermatologist as public health advocate, providing specific actionable items through which our specialty can positively address the climate change crisis and in turn protect the health of our patients now and in the future.
Baseline resting heart rate variability predicts post‐traumatic stress disorder treatment outcomes in adults with co‐occurring substance use disorders and post‐traumatic stress
Authors: Soder Heather E. , Wardle Margaret C. , Schmitz Joy M. , Lane Scott D. , Green Charles , Vujanovic Anka A. 
Published: April 2019

AbstractPost‐traumatic stress disorder (PTSD) symptoms are highly prevalent among individuals with substance use disorders (SUD), presenting a difficult‐to‐treat, complex comorbidity. Prognostic factors for treatment outcomes may characterize heterogeneity of the treated population and/or implicate mechanisms of action that are salient for improving treatments. High frequency heart rate variability (HF‐HRV) is a suggested biomarker for emotion regulation—the ability to generate appropriate emotional responses via the influence of the parasympathetic nervous system on the heart. This initial study investigated the utility of baseline resting HF‐HRV for predicting PTSD symptoms and substance use outcomes following treatment of 37 SUD participants with comorbid PTSD symptoms. Participants completed either standard cognitive‐ behavioral therapy (CBT) for SUD or a novel treatment of integrated post‐traumatic stress and substance use that combined CBT for SUD with cognitive processing therapy for PTSD. Analyses demonstrated that higher HF‐HRV predicted greater reduction in PTSD symptoms following both types of treatment. This suggests prognostic value of HF‐HRV as a predictor of PTSD treatment outcomes; those with poorer autonomic emotional regulation may not respond as well to psychotherapy in general. This hypothesis‐generating analysis identifies a putative biomarker that might have utility in treatment prediction.
The history of Classical Hebrew: From the invention of the alphabet to the Mishnah
Authors: Schniedewind William M. 
Published: April 2019

AbstractA lively debate has engulfed the study of the early history of the Hebrew language in the past two decades. Traditionally, scholars classified the language of the Hebrew Bible into three categories: Archaic, Standard, and Late Biblical Hebrew. But recent trends in biblical criticism have tended to date biblical literature much later, and some scholars date almost all of biblical literature to the Persian and Hellenistic periods. This trend undoes traditional linguistic categories for biblical Hebrew and questions the validity of the linguistic dating of biblical literature. In spite of the challenges, a modified and more complex model for the history of Classical Hebrew remains the working consensus model. A lively debate has engulfed the study of the early history of the Hebrew language in the past two decades, especially advanced by the work of Ian Young and Robert Rezetko (e.g., Young & Rezetko, ). Conferences have been organized to address this issue (e.g., Miller‐Naudé & Zevit, ). Young and Rezetko have continued to advocate for their approach in spite of critical reviews (e.g., Joosten, ). Traditionally, scholars have classified the language of the Hebrew Bible into three categories: Archaic Biblical Hebrew (that is, early biblical poems), Standard Biblical Hebrew (the major part of biblical literature), and Late Biblical Hebrew (comprising compositions from the Persian and Hellenistic periods). But trends in biblical criticism over the past several decades have tended to date biblical literature later and later. Now, one can find some prominent scholars who date almost all of biblical literature—and particularly Pentateuchal literature (Sommer, )—to the Persian and Hellenistic periods. This trend raises serious questions about the validity of the traditional linguistic dating of biblical literature. Although some have ignored this linguistic problem, others have offered a variety of rationales justifying the dismissal of linguistic dating. These divergent trends have resulted in continuing debate regarding the historical linguistics of Biblical Hebrew that is addressed in Ronald Hendel and Jan Joosten's recent book, How Old is the Hebrew Bible? (2018).
Surgical enlargement of the nasomaxillary aperture and transnasal conchotomy of the ventral conchal sinus: Two surgical techniques to improve sinus drainage in horses
Authors: Bach Fabienne Sabine , Böhler Alexandra , Schieder Katrin , Handschuh Stephan , Simhofer Hubert 
Published: April 2019

AbstractObjectiveTo evaluate 2 surgical techniques for establishing and/or improving paranasal sinus drainage in cadaver heads and horses with sinusitis and evaluate the feasibility of postoperative transnasal sinus endoscopy.Study designEx vivo study (equine cadaver heads) and case series.Sample populationNine adult equine cadaver heads and 8 horses with recurrent sinusitis.MethodsFor the ex vivo study, the following procedures were performed on 9 cadaver heads: preoperative and postoperative computed tomography (heads 1–6), endoscopy‐guided transnasal conchotomy of the ventral conchal sinus (TCVCS) and surgical enlargement of the nasomaxillary aperture (SENMAP) on opposite sides (heads 1–3), combined TCVCS and SENMAP on both sides (heads 4–9), evaluation of sinus drainage before and after surgery (heads 7–9), and postoperative transnasal endoscopy (heads 4–9). For the case series, 8 horses with secondary sinusitis were treated in standing position with SENMAP and/or TCVCS and postoperative transnasal endoscopy.ResultsSinonasal communications were successfully created in all cadavers and affected live horses. Transnasal endoscopy of all sinuses except the middle conchal sinus was possible in heads 4–9 and in all clinical cases. Sinus drainage was improved (P = .028) by combining techniques. Blood loss in live horses ranged from 0.5–5.5 L (1.95 ± 1.5) per horse. Sinusitis resolved in all affected horses during follow‐up of 3.2–25.5 months (13.5 ± 8.5).ConclusionTransnasal conchotomy of the ventral conchal sinus and SENMAP consistently created large sinonasal communications, facilitating sinus endoscopy and improving sinus drainage.Clinical significanceTransnasal conchotomy of the ventral conchal sinus and SENMAP are viable options to treat horses with sinusitis and anatomical obstructions of the sinonasal communications.
Congruences with Eisenstein series and -invariants
Authors: Bellaïche Joël , Pollack Robert 
Published: April 2019

We study the variation of$\unicode[STIX]{x1D707}$-invariants in Hida families with residually reducible Galois representations. We prove a lower bound for these invariants which is often expressible in terms of the$p$-adic zeta function. This lower bound forces these$\unicode[STIX]{x1D707}$-invariants to be unbounded along the family, and we conjecture that this lower bound is an equality. When$U_{p}-1$generates the cuspidal Eisenstein ideal, we establish this conjecture and further prove that the$p$-adic$L$-function is simply a power of$p$up to a unit (i.e. $\unicode[STIX]{x1D706}=0$). On the algebraic side, we prove analogous statements for the associated Selmer groups which, in particular, establishes the main conjecture for such forms.
Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatography (ERCP)-obtained biliary specimens improves the detection and management of patients with malignant bile duct strictures
Authors: Singhi Aatur D , Nikiforova Marina N , Chennat Jennifer , Papachristou Georgios I , Khalid Asif , Rabinovitz Mordechai , Das Rohit , Sarkaria Savreet , Ayasso M Samir , Wald Abigail I , Monaco Sara E , Nalesnik Michael , Ohori N Paul , Geller David , Tsung Allan , Zureikat Amer H , Zeh Herbert , Marsh J Wallis , Hogg Melissa , Lee Kenneth , Bartlett David L , Pingpank James F , Humar Abhinav , Bahary Nathan , Dasyam Anil K , Brand Randall , Fasanella Kenneth E , McGrath Kevin , Slivka Adam 
Published: April 2019

ObjectiveDespite improvements in imaging, serum CA19-9 and pathological evaluation, differentiating between benign and malignant bile duct strictures remains a diagnostic conundrum. Recent developments in next-generation sequencing (NGS) have opened new opportunities for early detection and management of cancers but, to date, have not been rigorously applied to biliary specimens.DesignWe prospectively evaluated a 28-gene NGS panel (BiliSeq) using endoscopic retrograde cholangiopancreatography-obtained biliary specimens from patients with bile duct strictures. The diagnostic performance of serum CA19-9, pathological evaluation and BiliSeq was assessed on 252 patients (57 trainings and 195 validations) with 346 biliary specimens.ResultsThe sensitivity and specificity of BiliSeq for malignant strictures was 73% and 100%, respectively. In comparison, an elevated serum CA19-9 and pathological evaluation had sensitivities of 76% and 48%, and specificities of 69% and 99%, respectively. The combination of BiliSeq and pathological evaluation increased the sensitivity to 83% and maintained a specificity of 99%. BiliSeq improved the sensitivity of pathological evaluation for malignancy from 35% to 77% for biliary brushings and from 52% to 83% for biliary biopsies. Among patients with primary sclerosing cholangitis (PSC), BiliSeq had an 83% sensitivity as compared with pathological evaluation with an 8% sensitivity. Therapeutically relevant genomic alterations were identified in 20 (8%) patients. Two patients withERBB2-amplified cholangiocarcinoma received a trastuzumab-based regimen and had measurable clinicoradiographic response.ConclusionsThe combination of BiliSeq and pathological evaluation of biliary specimens increased the detection of malignant strictures, particularly in patients with PSC. Additionally, BiliSeq identified alterations that may stratify patients for specific anticancer therapies.
Association of binge drinking in adolescence and early adulthood with high blood pressure: findings from the National Longitudinal Study of Adolescent to Adult Health (1994–2008)
Authors: Hayibor Lisa Ama , Zhang Jianrong , Duncan Alexis 
Published: April 2019

BackgroundAn investigation of the risk of high blood pressure (HBP) associated with heavy alcohol consumption in adolescence and early adulthood is lacking. Therefore, we aimed to investigate the association between binge drinking from adolescence to early adulthood and the risk of HBP in early adulthood.MethodsWe applied logistic regression to publicly available, population-representative data from waves I (1994–1995; ages 12–18) and IV (2007–2008; ages 24–32) of the National Longitudinal Study of Adolescent to Adult Health (n=5114) to determine whether past 12-month binge drinking in adolescence (wave I) and early adulthood (wave IV) was associated with HBP in early adulthood after adjusting for covariates, including smoking and body mass index. HBP was defined according to both the former and new classifications.ResultsHBP was significantly, positively associated with infrequent binge drinking (less than once a week) in adolescence based on the new classification (overall: OR 1.23, 95% CI 1.02 to 1.49; male: OR 1.35, 95% CI 1.00 to 1.81) and frequent binge drinking (heavy consumption) in adolescence based on the former classification (overall: OR= 1.64, 95% CI 1.22 to 2.22; male: OR= 1.79, 95% CI 1.23 to 2.60). The risk of HBP was high when participants engaged in frequent binge drinking in both adolescence and early adulthood, especially based on the former classification (overall: OR 2.43, 95% CI 1.13 to 5.20; female: OR 5.81, 95% CI 2.26 to 14.93).ConclusionBinge drinking in adolescence may increase risk of HBP in early adulthood. This association is independent of other important risk factors for HPB, such as smoking and obesity.
Stentriever salvage after failed manual aspiration thrombectomy
Authors: Tonetti Daniel A , Desai Shashvat M , Casillo Stephanie , Zussman Benjamin M , Jadhav Ashutosh , Jankowitz Brian Thomas , Jovin Tudor G , Gross Bradley A 
Published: April 2019

IntroductionManual aspiration thrombectomy (MAT) and stent retriever mediated aspiration thrombectomy (SMAT) are well described reperfusion strategies for large vessel occlusions. This study aims to identify predictors of successful crossover to SMAT after failed first pass MAT.MethodsProspectively collected data for patients with acute large vessel occlusions undergoing thrombectomy over a 23 month period at a comprehensive stroke center were reviewed. The primary outcome was successful removal of the index clot with resultant Thrombolysis in Cerebral Infarction 2b or greater reperfusion at any point after a failed initial MAT attempt, and multivariate logistic regression analyses were performed to determine predictors of successful crossover to SMAT.ResultsOf 433 large vessel thrombectomies, 319 underwent first pass MAT, and 113 patients required a repeated pass for the index thrombus. Second pass MAT was performed in 77% of cases and was successful in 54%; second pass SMAT was performed in 23% of cases and was successful in 73% (P=0.11). Third pass MAT was employed in 45% of cases and was successful in 43% while SMAT was performed in 55% of cases and was successful in 77% (P=0.03). Overall, 12% of patients undergoing MAT on the first pass crossed over to successful SMAT. Predictors of successful crossover were internal carotid artery (ICA) location and higher presenting National Institutes of Health Stroke Scale (NIHSS) score.ConclusionAfter failed first pass MAT, subsequent passes with SMAT had higher rates of successful index clot removal; patients with a higher initial NIHSS score and ICA clot location should be considered for early crossover or even initial SMAT for their clots.
In-Plane Free Vibration of Uniform Circular Arches Made of Axially Functionally Graded Materials
Authors: Lee Joon Kyu , Lee Byoung Koo 
Published: April 2019

This study focused on the in-plane free vibration of uniform circular arches made of axially functionally graded (AFG) materials. Based on the dynamic equilibrium of an arch element, the governing equations for the free vibration of an AFG arch are derived in this study, where arbitrary functions for the Young’s modulus and mass density are acceptable. For the purpose of numerical analysis, quadratic polynomials for the Young’s modulus and mass density are considered. To calculate the natural frequencies and corresponding mode shapes, the governing equations are solved using the direct integral method enhanced by the trial eigenvalue method. For verification purposes, the predicted frequencies are compared to those obtained by the general purpose software ADINA. A parametric study of the end constraint, rotatory inertia, modular ratio, radius parameter, and subtended angle for the natural frequencies is conducted and the corresponding mode shapes are reported.
Sequence learning is driven by improvements in motor planning
Authors: Ariani Giacomo , Diedrichsen Jörn 
Published: April 2019

The ability to perform complex sequences of movements quickly and accurately is critical for many motor skills. Although training improves performance in a large variety of motor sequence tasks, the precise mechanisms behind such improvements are poorly understood. Here we investigated the contribution of single-action selection, sequence preplanning, online planning, and motor execution to performance in a discrete sequence production task. Five visually presented numbers cued a sequence of five finger presses, which had to be executed as quickly and accurately as possible. To study how sequence planning influenced sequence production, we manipulated the amount of time that participants were given to prepare each sequence by using a forced-response paradigm. Over 4 days, participants were trained on 10 sequences and tested on 80 novel sequences. Our results revealed that participants became faster in selecting individual finger presses. They also preplanned three or four sequence items into the future, and the speed of preplanning improved for trained, but not for untrained, sequences. Because preplanning capacity remained limited, the remaining sequence elements had to be planned online during sequence execution, a process that also improved with sequence-specific training. Overall, our results support the view that motor sequence learning effects are best characterized by improvements in planning processes that occur both before and concurrently with motor execution. NEW & NOTEWORTHY Complex skills often require the production of sequential movements. Although practice improves performance, it remains unclear how these improvements are achieved. Our findings show that learning effects in a sequence production task can be attributed to an enhanced ability to plan upcoming movements. These results shed new light on planning processes in the context of movement sequences and have important implications for our understanding of the neural mechanisms that underlie skill acquisition.
Hand forces and placement are modulated and covary during anticipatory control of bimanual manipulation
Authors: Lee-Miller Trevor , Santello Marco , Gordon Andrew M. 
Published: April 2019

Dexterous object manipulation relies on the feedforward and feedback control of kinetics (forces) and kinematics (hand shaping and digit placement). Lifting objects with an uneven mass distribution involves the generation of compensatory moments at object lift-off to counter object torques. This is accomplished through the modulation and covariation of digit forces and placement, which has been shown to be a general feature of unimanual manipulation. These feedforward anticipatory processes occur before performance-specific feedback. Whether this adaptation is a feature unique to unimanual dexterous manipulation or general across unimanual and bimanual manipulation is not known. We investigated the generation of compensatory moments through hand placement and force modulation during bimanual manipulation of an object with variable center of mass. Participants were instructed to prevent object roll during the lift. Similar to unimanual grasping, we found modulation and covariation of hand forces and placement for successful performance. Thus this motor adaptation of the anticipatory control of compensatory moment is a general feature across unimanual and bimanual effectors. Our results highlight the involvement of high-level representation of manipulation goals and underscore a sensorimotor circuitry for anticipatory control through a continuum of force and placement modulation of object manipulation across a range of effectors. NEW & NOTEWORTHY This is the first study, to our knowledge, to show that successful bimanual manipulation of objects with asymmetrical centers of mass is performed through the modulation and covariation of hand forces and placements to generate compensatory moments. Digit force-to-placement modulation is thus a general phenomenon across multiple effectors, such as the fingers of one hand, and both hands. This adds to our understanding of integrating low-level internal representations of object properties into high-level task representations.
Transvaginal Repair of Vesico Vaginal Fistula: A 10-Year Experience with Analysis of Factors Affecting Outcomes
Authors: Kumar Manoj , Agarwal Samarth , Goel Apul , Sharma Ashish , Agarwal Ajay , Pandey Siddharth , Sankhwar Satya Narain 
Published: April 2019

Objectives: To highlight the transvaginal route as an excellent approach for repair of a simple trigonal, supra-trigonal vesico-vaginal and urethrovaginal fistulae without compromising on the successful patient outcomes. We also determine factors affecting outcomes in such patients. Materials and Methods: A retrospective analysis was carried out on 58 patients with simple trigonal, supra trigonal and urethrovaginal fistula who underwent transvaginal repair in the last 10 years. Simple fistulas were defined as fistula less than 3 cm in size or recurrent fistulae less than 1.5–2 cm in size and located either supra-trigonally (above the bar of mercier) or sub-trigonally (below the bar of mercier) as determined by cystoscopy. Results: Obstetric cause, due to obstructed labour, was the most common cause of fistula formation (68.96%), while remaining (29.31%) were attributed to hysterectomy. Primary fistulae were found in 68.9% of patients and recurrent fiistulae in 31.1% patients. The mean age of patients was 33.4 years. Average fistula size was 1.5 cm. The success rate of primary operation was 84.12% (50/58). On using a multivariate regression model, the underlying aetiology (OR 2.2), fistula location (OR 2.5) and history of previous repair (OR 2.4) were found to be significant factors affecting outcome. Conclusion: The transvaginal approach is less invasive and achieves comparable success rates as compared to other methods of vesico-vaginal fistula repair. This surgery with Foley catheter has a high success rate with reduced morbidity. We postulate that vaginal approach should be preferred over abdominal approach for repair of all vaginally accessible vesico vaginal fistulae, both of obstetrical and gynaecological origin.