bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aerial map demonstrates erosional patterns and changing topography at Isimila, Tanzania (with corrigendum)
Authors: Bergstrom Kersten , Lawrence Austin B. , Pelissero Alex J. , Hammond Lauren J. , Maro Eliwasa , Bunn Henry T. , Musiba Charles M. 
Published: July 2019

Isimila is a Middle Pleistocene archaeological site located in southern Tanzania. The site is known for large surface assemblages of later Acheulean lithics such as hand axes, cleavers, scrapers and cores. While hominin remains have yet to be discovered at the site, Isimila offers a unique window into Middle Pleistocene Homo behaviour. Although Isimila has been studied extensively, the last published map of the site and surrounding area was made available in the 1970s. Here, we present an updated high-resolution map of Isimila. Data for the map were collected during aerial survey with an uncrewed(unmanned) aerial vehicle. With this map, we identified new archaeological localities, erosional patterns, newly exposed geological features and changes in site topography. The map demonstrates patterns of stone tool and raw material distribution that may support previous hypotheses of short-distance raw material transport into the area by hominins. This open-access map establishes a baseline for tracking changes to site topography in the future and serves as a unique tool to enable collaboration between researchers, museum personnel and local populations to better conserve Isimila.
Significance:

New potential archaeological localities and significant changes to erosional patterns at Isimila were identified.
The open access map and associated raw data provided enable researchers to track seasonal and erosional changes and anthropogenic effects, and to develop protocols for conservation of this unique site.

Open data set:
https://doi.org/10.5281/zenodo.1470770
Immunohistochemical Expression of PTCH1 and Laminin in Oral Hyperplastic, Premalignant, Squamous Cell Carcinoma and Recurrence Lesions Samples
Authors: Hamaamin Kanar , Hussein Falah , Mohammad Dena 
Published: July 2019

Objective: Laminin is a basal membrane glycoprotein that showed progressive loss of continuity from dysplasia to invasive carcinoma. The membranous receptor Patched (PTCH1) promotes the nuclear translocation and activation of the Gli family proteins. The dysregulation of hedgehog signaling reported in various cancers. This study aims to assess the immunohistochemical expression of PTCH1 and laminin in different groups of lesions of oral hyperplastic, premalignant, oral squamous cell carcinoma (OSCC) and recurrence cases.
Methods: This study involved 35 paraffin blocks of 4 oral hyperplastic, 11 premalignant, 15 OSCC and five recurrences OSCC cases collected from Sulaimani Histopathological Centers. Prepared tissue sections were stained immunohistochemically for both PTCH1 and laminin antibodies and scored. Chi-square correlations used and the p 0.05 considered as statistically significant.
Results: PTCH1 showed expression in all oral hyperplastic lesions. While 81.8% of oral premalignant lesions demonstrated basal and parabasal distribution with high mixed localization (72.7%), lastly 93.3% of OSCC showed positive expression and mainly found within score 2(46.6%). No significant relations detected between oral hyperplastic and premalignant lesions regarding the expression pattern, localization and intensity as p-values were 0.77, 0.09 and 0.38 respectively. Lastly, the relations between OSCC and recurrent cases to both the expression and localization parameters were non-significant, as p-values were 0.15 and 0.09, respectively. Laminin showed continuous expression at the basement membrane of the normal oral mucosa, while only (50%) of the cases revealed such expression in oral hyperplastic lesions. The oral premalignant lesions expressed 54.5% of a discontinuous pattern. The relation between the oral hyperplastic and premalignant lesions in response to laminin expression was non-significant (P=.21). A significant relation found in laminin expression between OSCC and recurrence samples (p= 0.02). Finally, a significant correlation found between PTCH1 localization and laminin expression in oral premalignant lesions (p = 0.03).
Conclusions: The PTCH1 overexpression in all of the studied groups of lesions might give an impression of the active role of this biomarker in the progression toward malignancy. Laminin defragmentation, which started from dysplastic lesions extending to OSCC, could emphasize the role of this marker from the early precancerous stage. Furthermore, the combined PTCH1 mixed localization with discontinuous laminin expression might have a significant role in the progression of dysplastic lesions toward cancers.
Features of Seismic Sequences Are Similar in Different Crustal Tectonic Regions
Authors: Stallone Angela , Marzocchi Warner 
Published: July 2019

Abstract
We investigate the existence of possible differences in the earthquake clustering process in three areas related to distinct tectonic regimes: Italy, southern California, and Japan. At first, we separate the triggered and background components of seismicity of the three catalogs. Then, we analyze statistically the space–time domain of the earthquake clusters to identify possible variations in the triggering properties across the considered regions. Finally, we characterize the background seismicity in the three seismic catalogs to test whether it can be satisfactorily described by a time‐homogeneous Poisson process. Overall, our analysis shows similar features of the seismicity in the three tectonic regions. Specifically, we find common average earthquake clustering properties in the three tectonic regions superimposed on a background seismicity described by the Poisson process, with a time‐dependent rate. We conclude that, at least for the analyzed active seismic crustal regions, the tectonic regime does not seem to play a key role in affecting the average spatiotemporal clustering properties. Remarkably, we reach the same conclusion when inspecting the influence of subregions with homogeneous deformation style.
Forecasting Earthquakes by Hybrid Model of Pattern Informatic and PageRank Methods
Authors: Rezaei Soghra , Moghaddasi Hanieh , Darooneh Amir Hossein , Zare Mehdi 
Published: July 2019

Abstract
Although there is no proven method for predicting earthquakes in a short time, it is feasible to evaluate their hazards probabilistically. Here, we aim to find active and passive places of Iran’s geographical region. In this regard, we have analyzed pattern informatic (PI) and the relative intensity methods in Iran as retrospective binary forecasting methods, and used the PageRank (PR) algorithm to rank different places. Then, we introduce a hybrid model of PR and PI methods (PR‐PI) for prediction in the earthquakes network. The results show that our method turns out to be one of the most reliable forecasts compared to other methods based on the common relative operating characteristic diagram. We have also found a regional seismogenic map where earthquakes are likely to occur during a specific time interval in the future.
Influence of Rootstock and Variety on Leaf Nutrient Concentration of Pear Grown on a Nutrient-Sufficient Soil
Authors: ERDAL İbrahim , NAZLI İrfan 
Published: July 2019

Study was aimed to investigate the effect of
rootstock, variety and their combination on mineral nutrition of pear. For this reason, Deveci,
Santa Maria and Akca varieties grafted on Quince A, Quince C, BA 29 and OHF 333
rootstocks were used as plant materials. To compare nutritional status of
plants, N, P, K, Ca, Mg, Fe, Cu, Mn Zn and B analysis were made on leaf
samples. According to results, it was
seen that individual effect of rootstock and variety and their combinations had
significant effect on pear mineral nutrition generally. Although there was a
significant variation depending on rootstock and variety differences, we could
not reach a certain results which rootstock and variety or their
combinations were prominent on general mineral nutrient concentration of pear.
We assumed that this is due to preventing of the effectiveness of rootstock or
variety due to sufficient nutrient levels in the soil
MÜLKİYET HAKLARI VE REFAH İLİŞKİSİ: AB ÜLKELERİ ÜZERİNE PANEL VERİ ANALİZİ
Authors: ÇOBAN Mustafa Necati 
Published: July 2019

Kurumsal yapı içerisinde mülkiyet hakları,
refahı olumlu yönde etkileyebilen bir kavram olarak nitelendirilmektedir. Korunaklı
mülkiyet hakları bireylerin ekonomik özgürlüklerini desteklemekte ve bireysel
yatırımların, teşebbüslerin önünü açmaktadır. Çalışmada Avrupa Birliği
ülkelerinde 2007-2014 yılları arasını kapsayan veriler kullanılarak dengeli
panel veri analizi gerçekleştirilmiştir. Bu kapsamda mülkiyet hakları
göstergesi olarak Property Rights Alliance tarafından yayınlanan Uluslararası
Mülkiyet Hakları göstergesi kullanılmıştır. Refah göstergesi ve bağımlı
değişken olarak ise Legatum Institute tarafından yayınlanan Refah Endeksi ele
alınmıştır. Çalışmaya kontrol değişkenleri olarak ticari açıklık oranı, kamu eğitim harcamalarının GSYİH içindeki payı,
işsizlik oranı ve enflasyon oranı eklenmiştir. Çalışmada Avrupa Birliği ülkelerinde mülkiyet
haklarının refah üzerindeki etkisinin araştırılması amaçlanmaktadır. Bu amaç
doğrultusunda gerçekleştirilen panel veri analizi sonrasında Avrupa Birliği ülkelerinde
mülkiyet haklarının korunaklılığının gelişmesinin bu ülkelerde refah seviyesini
olumlu yönde etkilediği sonucuna ulaşılmıştır.
Role of vitamin D supplementation as adjunctive therapy to escitalopram in patients of major depressive disorder: a 8 week prospective, randomized, interventional, clinical study
Authors: Singh Shivangna , Sharma Priyamvada , Gautam Vivek 
Published: July 2019

Background: Depression is a major public health problem and occurs in persons of all ages, and is associated with increased morbidity, soaring costs for treatment and reduced productivity and quality of life. Vitamin D is involved in numerous brain processes including neuroimmunomodulation, neuroprotection, neuroplasticity, regulation of neurotrophic factors, and making it biologically plausible to be associated with depression. Aim of the present study is to compare the therapeutic effects of vitamin D given along with escitalopram versus escitalopram given alone in patients with major depressive disorder. Methods: In this prospective, randomized, interventional clinical study, 60 patients with a diagnosis of major depressive disorder based on ICD-10 criteria were randomly assigned into two groups, one group received 60000IU vitamin D3 weekly plus 10 mg escitalopram OD daily while the other group received escitalopram10 mg OD daily alone for 8 weeks. Depression severity was assessed at 2-week intervals using the 24-item Hamilton Depression Rating Scale (HDRS). Serum 25(OH) vitamin D levels were measured in all the patients at baseline and after intervention.Result: Fifty nine patients completed the trial. Depression severity based on HDRS decreased significantly after intervention, with a significant difference between the two groups. The vitamin D3+escitalopram combination was significantly better than escitalopram alone from the fourth week of treatment. Conclusion: Role of vitamin D in mood disorder and its dietary supplementation is effective as an adjuvant treatment along with SSRIs in depressive disorders, especially in vitamin D deficient patients.
Prucalopride: novel drug for chronic idiopathic constipation
Authors: Dhull Pawan , Maggo Sachin , Angrish Piyush , Singh Anuj , S. Uthara K. , S. Akhila A. 
Published: July 2019

Chronic Idiopathic Constipation (CIC), defined as constipation in which the underlying cause is unknown, is a common medical illness with a profound negative impact on health-related quality of life and increased propensity for life threatening complications. Current treatment for CIC includes lifestyle modifications, over-the-counter medications, and prescription medications. Presently, the only approved, prescription products for CIC in the US are prosecretory agents. However, the current knowledge that serotonin plays an important role in colonic motility has opened new horizons in the treatment of CIC promoting use of prokinetic agents with a different mechanism of action. Prucalopride is a highly selective 5-hydroxytryptamine type 4 (5-HT4) receptor agonist that enhances propulsive motor patterns in the large intestine due to a high affinity for 5-HT4 receptors in gastrointestinal (GI) tissues. The onset of action of Prucalopride is fast, shows rapid absorption, oral bioavailability of 93% and linear pharmacokinetics. Most common adverse reactions seen are headache, nausea, diarrhea, and abdominal pain. Clinical trials for Prucalopride have been positive, and results suggest that the drug may be a new safe and effective option for CIC treatment, especially for patient’s refractory to prosecretory agents. As a prescription drug for the management of constipation and given the virtual demise of other prokinetic agents for this indication, prucalopride competes primarily with another class of agents: those that stimulate secretion. With Shire Pharmaceuticals having already received US FDA approval in Dec 2018, Prucalopride may soon be a new addition to the mounting armoury of drugs against CIC.
Risk Assessment of Cardiac Events in Patients with Stable Ischemic Heart Disease After Percutaneous Coronary Intervention, Accompanied by Myocardial Damage
Authors: Vorobyova A. V. , Bondarenko B. B. , Bart V. A. , Malgina M. P. , Dorofeykov V. V. , Kuleshova E. V. 
Published: July 2019

Background.Percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD) is followed often by myocardial injury. Up to now there is no mutual agreement to the inﬂ uence of the perioperative myocardial injury on the long-term prognosis of the IHD patients.Objective.The aim of study was to assess the risk factors for the development of cardiac events in the long-term period in patients with stable coronary artery disease with myocardial damage after PCI.Materials and methods. The study included 113 patients with stable coronary artery disease who underwent planned PCI. Serum troponin levels were determined before and 24 hours after the intervention. Re-examination of patients was carried out after 12–18 months (average 15 months).Results. The post PCI Tn I level over a reference one was registered in 25 patients (22,2 %). During the follow-up period the cardiovascular events took place in 25,6 % patients: acute myocardial infarction (MI) in 3 (2,6 %), angina occurred in 23 %. One-way ANOVA revealed a signiﬁ cant value for cardiac risk events of the patient age, number of stenosed arteries, summary degree of stenosis, and their complicity, number of implanted stents. The ﬁ rst three of them were included in the ﬁ nal combination of the stepwise discriminant analysis. The general linear model of the latter detected additionally statistical signiﬁ cance of the variables “MI in the past” (before PCI) and “number of postdilatations“.Conclusion. In patients with stable ischemic heart disease, included in the study, the determining risk factors for the development of cardiac events were the prevalence and nature of the obstructive lesion of the coronary bed, age, previous myocardial infarction, and especially the performance of PCI. Myocardial damage was not identiﬁ ed as a risk factor for recurrent angina or myocardial infarction.
Takotsubo syndrome after induction of general anesthesia: three clinical cases
Authors: Klimov A. A. , Buldakov M. Yu. , Gritskevich M. V. , Zabaluev D. A. , Kamnev S. A. , Malakhova A. A. , Novikova E. V. , Osokin Ya. A. , Subbotin V. V. 
Published: July 2019

Takotsubo syndrome (stress-induced cardiomyopathy, or apical ballooning syndrome) is a rare critical condition with approximate incidence of 0.00006% and relatively favorable prognosis. It is characterized by electrocardiographic signs of myocardial ischemia, as well as by severe left ventricular failure with intact coronary vessels. The literature on postoperative development of this disease is scarce. This paper presents three documented cases of takotsubo syndrome with favorable outcomes that developed just after the induction of general anesthesia.
AS PERIODIZAÇÕES DA HISTÓRIA GERAL E DA HISTÓRIA ANTIGA NOS MANUAIS DE ENSINO DE HISTÓRIA NO BRASIL: limitações e proposições
Authors: FARIAS JÚNIOR JOSÉ PETRÚCIO DE 
Published: July 2019

A periodização é um recurso didático do qual a maioria dos docentes, em diferentes ná­veis de ensino, faz uso. Indagar a configuração da periodização histórica equivale, a nosso ver, a questionar a maneira pela qual significamos o passado; prática que nos permite, por extensão, lançar novos olhares á s grandes narrativas que compõem a chamada ”História Geral”. Diante disso, objetivamos, neste artigo, analisar as implicações ideológicas por trás da divisão quadripartite da História Geral, no interior da qual se situa a História Antiga, e apresentar propostas de periodização que valorizam os processos de interação transcultural.Palavras-chave: Periodização. História Geral. História Antiga. THE PERIODIZATIONS OF GENERAL AND ANCIENT HISTORY IN HISTORY TEACHING GUIDEBOOKS IN BRAZIL: limitations and propositions Abstract: Periodization is a didactic resource that most teachers, at different levels of education, make use of. To inquire into the configuration of historical periodization is equivalent, in our view, to question the manner in which we signify the past; a practice that allows us, by extension, to throw new perspectives at the narratives that make up the so-called ”˜General History”™. In this article, we aim to analyze the ideological implications behind the traditional division of General History, within which Ancient History is situated, and discuss periodization proposals that value the processes of cross-cultural interaction.Keywords: Periodization. Ancient History. General History. LAS PERIODIZACIONES DE LA HISTORIA GENERAL Y LA HISTORIA ANTIGUA EN LOS MANUALES DE ENSEá‘ANZA DE HISTORIA EN BRASIL: limitaciones y proposicionesResumen: La periodización es un recurso didáctico del cual la mayorá­a de los docentes, en diferentes niveles de enseñanza, hace uso. Indagar la configuración de la periodización histórica equivale, a nuestro ver, a cuestionar la manera como significamos el pasado, práctica que nos permite, por extensión, lanzar nuevas miradas a las grandes narrativas que componen la llamada ”Historia General”. En este artá­culo, analizamos las implicaciones ideológicas detrás de la división cuatripartita de la Historia General, dentro de la cual se sitúa la Historia Antigua, y presenta propuestas de periodización que valoran los procesos de interacción transcultural.Palabras clave: Periodización. Historia Antigua. Historia General.
PESQUISA E ENSINO DE HISTÓRIA ANTIGA: PARA QUáŠ? Diferentes visões da Antiguidade
Authors: TACLA ADRIENE BARON 
Published: July 2019

Qual é o lugar da pesquisa e do ensino de História antiga no Brasil? Para onde estamos indo? Que perspectivas temos e que novos caminhos temos traçado? Este artigo deriva dos recentes debates sobre o ensino e a pesquisa da História Antiga no Brasil, particularmente das contendas sobre a BNCC, bem como os atuais ataques contra a Ciência e a Educação brasileiras. Aqui, pretendo discutir a lacuna que se evidencia entre a pesquisa acadêmica e tais atitudes com relação ao trabalho de antiquistas em nossa sociedade.Palavras-chave: Polá­tica. Ensino de História Antiga. Pesquisa Cientá­fica. ANCIENT HISTORY REASEARCH AND TEACHING: WHAT FOR?Different views on AntiquityAbstract: Which is the place of Ancient History teaching and research in Brazil? Where is it going to? Which perspectives do we have and what new paths have we opened up? This paper derives from the recent debates on Ancient History teaching and research in Brazil, particularly the contentions about the NCCB, as well as from the current attacks towards Brazilian Science and Education. Here, I aim to discuss the gap that is evinced between the academic research and such attitudes with regard to the work of antiquists in our society.Keywords: Politics. Ancient History Teaching. Scientific Research. INVESTIGACIÓN Y ENSEá‘ANZA DE HISTORIA ANTIGUA: ¿PARA QUÉ?Diferentes visiones de la Antigá¼edadResumen: ¿Cuál es el lugar de la investigación cientá­fica y de la enseñanza de la Historia Antigua en Brasil? ¿Para dónde estamos yendo? ¿Qué perspectivas tenemos y qué otros caminos trazamos? Este artá­culo deriva de los debates acerca de la enseñanza y la investigación de la Historia Antigua en Brasil, en particular de las controversias sobre la BNCC, bien como de los ataques actuales contra la ciencia y la educación brasileñas. Aquá­, hablo de una brecha que se evidencia entre la práctica académica y en las actitudes con relación al trabajo de los antiquistas en nuestra sociedad.Palabras clave: Polá­tica. Enseñanza de la Historia Antigua. Investigación Cientá­fica.
PENGEMBANGAN MODUL PEMBELAJARAN KIMIA BERBASIS POE (PREDICT, OBSERVE, EXPLAIN) PADA MATERI LARUTAN ELEKTROLIT DAN NON ELEKTROLIT
Authors: Jayanti Etrie 
Published: July 2019

Penelitian ini merupakan R&D (research and development) yang bertujuan untuk mengetahui validitas dan respon siswa terhadap modul pembelajaran kimia berbasis POE (predict, observe, explain) pada materi larutan elektrolit dan non elektrolit.
Prosedur pengembangan dari penelitian ini mengadopsi model pengembangan produk Borg & Gall. Penelitian ini melibatkan tiga validator yaitu validator ahli materi, validator ahli media/desain dan validator praktisi pendidikan/guru bidang studi. Subjek uji coba skala kecil dan uji coba skala menengah adalah siswa SMA N 3 Palembang. Instrumen pengumpulan data menggunakan lembar validasi, angket responden siswa dan pedoman wawancara. Hasil penelitian menunjukkan bahwa modul pembelajaran kimia berbasis POE (predict, observe, explain) pada materi larutan elektrolit dan non elektrolit memperoleh nilai persentase dari ahli materi sebesar 83,3% dan dinyatakan dalam kategori valid, ahli desain/media memberikan penilaian dengan persentase sebesar 97,2% dan dinyatakan dalam kategori sangat valid, praktisi pendidikan/guru bidang studi memberikan penilaian dengan persentase 88,8% dan dinyatakan dalam kategori sangat valid. Rata-rata persentase nilai dari tiga validator mencapai 89,9% dan dinyatakan pada kategori sangat valid. Respon siswa terhadap modul pembelajaran kimia berbasis POE (predict, observe, explain) pada materi larutan elektrolit dan non elektrolit dapat dikategorikan baik dimana pada uji skala kecil memperoleh persentase nilai sebesar 78,9% dan dinyatakan dalam kategori baik, pada uji skala menengah memperoleh persentase nilai sebesar 82,0% dan dinyatakan dalam kategori baik.

Kata-kata kunci: modul, POE (predict, observe, explain), larutan elektrolit & non elektrolit
KARAKTERISTIK LEARNING OBTACLES (LO) YANG TERINDENTIFIKASI PADA POKOK BAHASAN TERMOKIMIA DI KELAS XI SMAN 16 PADANG
Authors: Yuhelman Nofri , Murwindra Rosa 
Published: July 2019

Kesulitan belajar akan tampak jelas dari menurunnya kinerja akademis atau prestasi belajar siswa. Guru harus dapat mengidentifikasi kemungkinan kesulitan belajar. Penelitian ini bertujuan untuk mengidentifikasi karakterisktik learning obtacles (LO) pada konsep Termokimia pada kelas XI SMA. Penelitian ini dilakukan di SMAN 16 Padang dengan jumlah populasi sebanyak 34 siswa kelas XI IPA dan 2 orang guru kimia. Instrumen yang digunakan dalam penelitian ini adalah butiran soal TKR (Tes Kemampuan Responden)lembaran observasi dan pedoman wawancara pada konsep termokimia. TKR yang digunakan dalam penelitian ini sebanyak 10 soal. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif dengan pendekatan penelitian desain didaktis (Didactical Design Research). Penelitian dimulai dari observasi, wawancara, dan pembuatan TKR (Tes Kemampuan Responden). Berdasarkan hasil penelitian didapatkan hambatan belajar siswa yaitu learning obtacle terkait connection, learning obtacle terkait conceptual, learning obtacle terkait construction dan learning obtacle terkait struktural. Hal ini ditunjukkan dari hasil TKR (test kemampuan responden) pada pembelajaran termokimia.