bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psalm 20 and Papyrus Amherst 63: A Window to the Dynamic Nature of Poetic Texts
Authors: Kister Menahem 
Published: September 2019

Abstract
An integrative study of the two prayers—Ps 20 and the Aramaic hymn in papyrus Amherst 63—reciprocally illuminates their inherent complexity and enables us to trace the intricate paths of their evolution.
Homeric Rewriting in Greek Sirach
Authors: Aitken James K. 
Published: September 2019

Abstract
It has been recognized in recent scholarship that the Greek translation of Sirach is subtle in its use of word-play and inner-Greek allusion. One such case, the story of the wandering man in Sir (31)34:9-13, can be shown to be a narration of two types of person, the one who wanders for positive learning and the one who errs and is in danger of death. It is thus not the personal experience of the author who has the freedom to travel in the new Hellenistic empires, but a moral tale modelled upon the two types of Odysseus that developed in the Greek tradition. This demonstrates the crafting of the source by the translator on the discourse level and hints at his educational background. It also has consequences for the larger structure of the unit in Sirach and further undermines the idea of a personal biography of Ben Sira.
An Anatomic Variant of the Ansa Cervicalis Precluding Its Use as a Donor Nerve
Authors: Zhu Alexander , Mohan Suresh , Richmon Jeremy D. , Jowett Nate 
Published: September 2019

Background: The ansa cervicalis is useful for cranial nerve repair, and may be harvested without apparent morbidity. Herein we report an unusual and surgically relevant anatomic variant of the ansa cervicalis. Methods: An adult male with left parotid adenoid cystic carcinoma underwent parotidectomy with upper-division facial nerve resection and planned interposition repair using the ansa cervicalis. The ipsilateral hypoglossal nerve was identified, together with a descending branch producing strap muscle contraction when stimulated. This presumed descendens hypoglossi was unusually large in caliber; further dissection revealed continuity with the vagus nerve. Results: Ansa cervicalis harvest was aborted when its separation from vagus nerve epineurium was not possible. The sural nerve was alternatively harvested. The patient awoke with left vocal fold palsy, which completely resolved within 3 months. Conclusion: Anatomic variants of the ansa cervicalis exist that may preclude graft harvest and place the vagus nerve at risk of inadvertent injury.
Online Health Information Seeking Among US Adults: Measuring Progress Toward a Healthy People 2020 Objective
Authors: Finney Rutten Lila J. , Blake Kelly D. , Greenberg-Worisek Alexandra J. , Allen Summer V. , Moser Richard P. , Hesse Bradford W. 
Published: September 2019

Objective: During the past decade, the availability of health information online has increased dramatically. We assessed progress toward the Healthy People 2020 (HP2020) health communication and health information technology objective of increasing the proportion of health information seekers who easily access health information online. Methods: We used data from 4 administrations of the Health Information National Trends Survey (HINTS 2008-2017) (N = 18 103). We conducted multivariable logistic regression analysis to evaluate trends over time in experiences with accessing health information and to examine differences by sociodemographic variables (sex, age, race/ethnicity, education, income, metropolitan status) separately for those who used the internet (vs other information sources) during their most recent search for health information. Results: Among US adults who looked for health information and used the internet for their most recent search, the percentage who reported accessing health information without frustration was stable during the study period (from 37.2% in 2008 to 38.5% in 2017). Accessing information online without frustration was significantly and independently associated with age 35-49 (vs age 18-34) (odds ratio [OR] = 1.34; 95% confidence interval [CI], 1.03 -1.73), non-Hispanic black (vs non-Hispanic white) race/ethnicity (OR = 2.15; 95% CI, 1.55-2.97), and annual household income <$20 000 (vs >$75 000) (OR = 0.66; 95% CI, 0.47-0.93). The percentage of adults who used an information source other than the internet and reported accessing health information online without frustration ranged from 31.3% in 2008 to 42.7% in 2017. Survey year 2017 (vs 2008) (OR = 1.61; 95% CI, 1.09-2.35) and high school graduate education (vs college graduate) (OR = 0.69; 95% CI, 0.49-0.97) were significantly and independently associated with accessing health information without frustration from sources other than the internet. Conclusions: The percentage of online health information seekers reporting easily accessing health information did not meet the HP2020 objective. Continued efforts are needed to enable easy access to online health information among diverse populations.
Long-term outcomes of elective transcatheter dense coil embolization for splenic artery aneurysms: a two-center experience
Authors: Wang Wujie , Chang Haiyang , Liu Bin , Wang Wei , Yu Zhe , Chen Chao , Li Yuliang , Wang Zhenting , Wang Yongzheng 
Published: September 2019

Objective This study was performed to analyze the long-term follow-up safety and efficacy of transcatheter dense coil embolization for splenic artery aneurysms. Methods Thirty-two patients (18 women, 14 men; age range, 23–56 years; mean age, 43.1 ± 13.6 years) who underwent dense coil embolization for treatment of splenic artery aneurysms from August 2010 to January 2018 were retrospectively reviewed. The size and location of the splenic artery aneurysms, the technical and clinical outcomes of the procedure, and the complications related to the procedure were reviewed. Results The technical success rate of embolization was 100% (mean aneurysm size, 29.4 ± 6.9 mm; range, 20–43 mm). Two (6.3%) patients underwent a successful repeat intervention procedure for recurrent aneurysm perfusion during follow-up (mean, 36 months; range, 6–72 months). No aneurysm ruptured during follow-up. Splenic infarction was observed in 8 of 32 (25%) patients. No patients developed major adverse events related to the procedure, such as splenic abscess or pancreatitis. Conclusions Percutaneous elective transcatheter dense coil embolization is safe and effective to prevent aneurysm rupture and overcome aneurysm recanalization during long-term follow-up.
FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors
Authors: Li Gen , Wang Li , Zhang Kunlin , Cao Chengqi , Cao Xing , Fang Ruojiao , Liu Ping , Luo Shu , Zhang Xiangyang 
Published: September 2019

Background: Post-traumatic stress disorder (PTSD) and depression are common mental disorders in individuals experiencing traumatic events. To date, few studies have studied the relationship between genetic basis and phenotypic heterogeneity of traumatized individuals. The present study examined the effects of four FKBP5 SNPs (rs1360780, rs3800373, rs9296158, and rs9470080) in four postdisaster groups (low symptom, predominantly depressive, predominantly PTSD, and combined PTSD-depression symptom groups) as identified by latent profile analysis. Methods: A total of 1,140 adults who experienced the 2008 Wenchuan earthquake participated in our study. Earthquake-related trauma, PTSD, and depressive symptoms were measured using standard psychometric instruments. The four FKBP5 SNPs were genotyped using a custom-by-design 2 × 48-Plex SNP scan™ Kit. Results: After adjusting for covariates, the main and gene–environment interaction effects of rs9470080 were all significant when the combined PTSD-depression group was compared with the low symptoms, predominantly depression and predominantly PTSD groups. rs9470080 TT genotype carriers had a higher risk of developing high co-occurring PTSD and depression symptoms than the C allele carriers. However, when trauma exposure was severe, the TT genotype carriers and C allele carriers did not differ in the risk of developing high co-occurring PTSD and depressive symptoms. The other three SNPs demonstrated no significant effects. Moreover, the rs3800373-rs9296158-rs1360780-rs9470080 haplotype A-G-C-T was found significantly associated with combined PTSD-depression symptoms. Conclusion: Our findings support the genetic basis of phenotypic heterogeneity in people exposed to trauma. Furthermore, the results reveal the possibility that the variants of FKBP5 gene may be associated with depression-PTSD comorbidity.
Gender Differences in the Association Between Hearing Loss and Cognitive Function
Authors: Huang Bowen , Cao Guilan , Duan Yanran , Yan Siyu , Yan Mingming , Yin Ping , Jiang Hongwei 
Published: September 2019

Objective: This study aimed to determine the association between hearing loss and cognitive function by gender in a nationally representative sample of older adults. Methods: We used data from the National Health and Nutrition Examination Survey (2010-2011) for 655 participants aged 60 to 69 years. The cognitive functioning component consisted of the Consortium to Establish a Registry for Alzheimer’s disease, the Animal Fluency Test, and the Digit Symbol Substitution Test. We created a composite z score to represent global cognitive function. Regression models were used to examine the association between hearing loss and cognitive function. Results: Moderate/severe hearing loss was significantly associated with lower composite z score in males (β = −28.67, 95% confidence interval [95% CI] = −57.13 to −0.20) but not in females (β = −8.82, 95% CI = −36.61 to 18.96). Conclusion: There were gender differences in the association between hearing loss and cognitive function. Future studies need to investigate these gender-specific associations.
Protection of digital health information: Examining guidance from the physician regulatory colleges in Canada
Authors: Barr Neil G , Randall Glen E 
Published: September 2019

Background: The use of information and communication technology (ICT) has tremendous potential to enhance communication among physicians, leading to improvements in service delivery. However, the protection of health information in digital/electronic format is an ongoing concern. Objective: The purpose of this study was to examine guidance for the protection of health information when using ICT from all 10 of Canada’s provincial regulatory colleges for physicians and to discuss the potential policy and service delivery implications. Method: A search of the regulatory college websites was conducted, followed by a document analysis (content and thematic). Results: The college website search identified 522 documents; 12 of these documents (from 8 of the 10 colleges) met the study criteria. These documents were notable for the considerable variation in the scope and detail of guidance provided across the colleges. Conclusion: While the federal–provincial division of powers in Canada enables different jurisdictional approaches to health service delivery and, thus, opportunities for policy learning, this governing structure may also contribute to a lack of incentive for collaboration, leading to an absence of standardised guidance for health information protection when using ICT. This, in turn, may result in unequal and inequitable protection of health information across the provinces. Therefore, a macro-level approach to policy development in this area may hold the greatest promise for enhancing the protection of health information and doing so in a more standardised manner in countries with federal systems of governance.
Recognizing the Dying Patient, When Less Could be More: A Diagnostic Framework for Shared Decision-Making at the End of Life
Authors: Kalsi Dilraj , Ward Joel , Lee Regent , Wee Bee , Fulford Kenneth WM , Handa Ashok 
Published: September 2019

Background: Recognizing dying patients is crucial to produce outcomes that are satisfactory to patients, their families, and clinicians. Aim: Earlier discussion of and shared decision-making around dying to improve these outcomes. Design: In this study, we interviewed 16 senior clinicians to develop summaries of palliative care in 4 key specialties: Cardiology, Vascular Surgery, Emergency General Surgery, and Intensive Care. Setting: Oxford University Hospitals. Results: Based on themes common to our 4 clinical areas, we developed a novel diagnostic framework to support shared palliative decision-making that can be summarized as follows: 1) Is the acute pathology reversible? 2) What is the patient’s physiological reserve? 3) What is important to the patient? Will they be fit enough for discharge for a reasonable length of time? Conclusions: We believe that education using this framework in the medical school and postgraduate curricula would significantly improve recognition of dying patients. This would serve to stimulate earlier conversations, more shared decision-making, and ultimately better outcomes in palliative care and patient experience.
Bavsiite, Ba2V2O2[Si4O12], mineral data and crystal structure
Authors: Bojar Hans-Peter , Walter Franz , Baumgartner Judith 
Published: September 2019

AbstractBavsiite from the type locality Gun Claim, Yukon Territory, Canada, occurs as millimetre-sized sky-blue platy crystals in a barium-rich low-temperature skarn related to a porphyritic quartz monzonite stock. Associated minerals are alstonite, baryte, celsian, diopside, fresnoite, mica, suzukiite, walstromite, witherite and minerals of the cerchiaraite group. Bavsiite is optical uniaxial (+), with ω = 1.725(3) and ε = 1.750(3) (589 nm) and pleochroic. Electron microprobe analyses yielded the empirical formula Na0.02Ba1.98Ti0.16Fe2+0.03V4+1.80 Al0.05Si4.00O14 based on 14 oxygen atoms, the simplified chemical formula is Ba2V2Si4O14. Bavsiite is tetragonal, space group I4/m, a = 7.043(1), c = 11.444(2) Å and Z = 2 obtained from single crystal data at 100 K, which are in good agreement with cell parameters from powder diffraction data at 293 K: a = 7.051(1) Å and c = 11.470(1) Å. The eight strongest lines of the powder X-ray diffraction pattern are [d, Å (I,%)(hkl)]: 3.76(30)(112), 3.36(44)(013), 3.004(100)(022), 2.493(43)(220), 2.486(67)(114), 2.286(24)(222), 1.785(39)(116) and 1.763(25)(040). The crystal structure was refined to R = 0.0159 based upon 312 unique reflections with I > 2σ(I). The crystal structure of bavsiite comprises unbranched single [Si4O12]8– rings connected by [VO5]6– square pyramids and BaO12 polyhedra. It can also be considered as cage–like [Si4V2O18]12– clusters built by four SiO4 tetrahedra and two VO5 square pyramids. These clusters are cross–linked to form a pseudo-two-dimensional network (2D) parallel to (001) containing empty channels along the a axis and the 2D networks held together by Ba2+ ions located in channels parallel to the c axis. The structural formula is Ba2V2O2[Si4O12]. Bavsiite is polymorphic to suzukiite, BaVSi2O7, which is orthorhombic.
A network embedding-based multiple information integration method for the MiRNA-disease association prediction
Authors: Gong Yuchong , Niu Yanqing , Zhang Wen , Li Xiaohong 
Published: September 2019

AbstractBackgroundMiRNAs play significant roles in many fundamental and important biological processes, and predicting potential miRNA-disease associations makes contributions to understanding the molecular mechanism of human diseases. Existing state-of-the-art methods make use of miRNA-target associations, miRNA-family associations, miRNA functional similarity, disease semantic similarity and known miRNA-disease associations, but the known miRNA-disease associations are not well exploited.ResultsIn this paper, a network embedding-based multiple information integration method (NEMII) is proposed for the miRNA-disease association prediction. First, known miRNA-disease associations are formulated as a bipartite network, and the network embedding method Structural Deep Network Embedding (SDNE) is adopted to learn embeddings of nodes in the bipartite network. Second, the embedding representations of miRNAs and diseases are combined with biological features about miRNAs and diseases (miRNA-family associations and disease semantic similarities) to represent miRNA-disease pairs. Third, the prediction models are constructed based on the miRNA-disease pairs by using the random forest. In computational experiments, NEMII achieves high-accuracy performances and outperforms other state-of-the-art methods: GRNMF, NTSMDA and PBMDA. The usefulness of NEMII is further validated by case studies. The studies demonstrate the great potential of network embedding method for the miRNA-disease association prediction, and SDNE outperforms other popular network embedding methods: DeepWalk, High-Order Proximity preserved Embedding (HOPE) and Laplacian Eigenmaps (LE).ConclusionWe propose a new method, named NEMII, for predicting miRNA-disease associations, which has great potential to benefit the field of miRNA-disease association prediction.
Mitochondrial and nuclear genetic analyses of the tropical black-lip rock oyster (Saccostrea echinata) reveals population subdivision and informs sustainable aquaculture development
Authors: Nowland Samantha J. , Silva Catarina N. S. , Southgate Paul C. , Strugnell Jan M. 
Published: September 2019

AbstractBackgroundThe black-lip rock oyster (Saccostrea echinata) has considerable potential for aquaculture throughout the tropics. Previous attempts to farmS. echinatafailed due to an insufficient supply of wild spat; however, the prospect of hatchery-based aquaculture has stimulated renewed interest, and small-scale farming is underway across northern Australia and in New Caledonia. The absence of knowledge surrounding the population genetic structure of this species has raised concerns about the genetic impacts of this emerging aquaculture industry. This study is the first to examine population genetics ofS. echinataand employs both mitochondrial cytochrome c oxidase subunit I gene (COI) and single nucleotide polymorphism (SNP) markers.ResultsThe mitochondrial COI data set included 273 sequences of 594 base pair length, which comprised 74 haplotypes. The SNP data set included 27,887 filtered SNPs for 272 oysters and of these 31 SNPs were identified as candidate adaptive loci. Data from the mitochondrial COI analyses, supports a broad tropical Indo-Pacific distribution ofS. echinata,and showed high haplotype and nucleotide diversities (0.887–1.000 and 0.005–0.008, respectively). Mitochondrial COI analyses also revealed a ‘star-like’ haplotype network, and significant and negative neutrality tests (Tajima’sD = − 2.030, Fu’sFs = − 25.638,P < 0.001) support a recent population expansion after a bottleneck. The SNP analyses showed significant levels of population subdivision and four genetic clusters were identified: (1) the Noumea (New Caledonia) sample location; (2) the Bowen (north Queensland, Australia) sample location, and remaining sample locations in the Northern Territory, Australia (n = 8) were differentiated into two genetic clusters. These occurred at either side of the Wessel Islands and were termed (3) ‘west’ and (4) ‘east’ clusters, and two migrant individuals were detected between them. The SNP data showed a significant positive correlation between genetic and geographic distance (Mantel test,P < 0.001,R2 = 0.798) and supported isolation by distance. Three candidate adaptive SNPs were identified as occurring within known genes and gene ontology was well described for the sex peptide receptor gene.ConclusionsData supports the existence of genetically distinct populations ofS. echinata, suggesting that management of wild and farmed stocks should be based upon multiple management units. This research has made information on population genetic structure and connectivity available for a new aquaculture species.
CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts
Authors: Aoki M. , Koga K. , Miyazaki M. , Hamasaki M. , Koshikawa N. , Oyama M. , Kozuka-Hata H. , Seiki M. , Toole B. P. , Nabeshima K. 
Published: September 2019

AbstractBackgroundInteraction between cancer cells and fibroblasts mediated by extracellular matrix metalloproteinase inducer (emmprin, CD147) is important in the invasion and proliferation of cancer cells. However, the exact mechanism of emmprin mediated stimulation of matrix metalloprotease-2 (MMP-2) production from fibroblasts has not been elucidated. Our previous studies using an inhibitory peptide against emmprin suggested the presence of a molecule on the cell membrane which forms a complex with emmprin. Here we show that CD73 expressed on fibroblasts interacts with emmprin and is a required factor for MMP-2 production in co-cultures of sarcoma cells with fibroblasts.MethodsCD73 along with CD99 was identified by mass spectrometry analysis as an emmprin interacting molecule from a co-culture of cancer cells (epithelioid sarcoma cell line FU-EPS-1) and fibroblasts (immortalized fibroblasts cell line ST353i). MMP-2 production was measured by immunoblot and ELISA. The formation of complexes of CD73 with emmprin was confirmed by immunoprecipitation, and their co-localization in tumor cells and fibroblasts was shown by fluorescent immunostaining and proximity ligation assays.ResultsStimulated MMP-2 production in co-culture of cancer cells and fibroblasts was completely suppressed by siRNA knockdown of CD73, but not by CD99 knockdown. MMP-2 production was not suppressed by CD73-specific enzyme inhibitor (APCP). However, MMP-2 production was decreased by CD73 neutralizing antibodies, suggesting that CD73-mediated suppression of MMP-2 production is non-enzymatic. In human epithelioid sarcoma tissues, emmprin was immunohistochemically detected to be mainly expressed in tumor cells, and CD73 was expressed in fibroblasts and tumor cells: emmprin and CD73 were co-localized predominantly on tumor cells.ConclusionThis study provides a novel insight into the role of CD73 in emmprin-mediated regulation of MMP-2 production.