bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology and management burden of invasive fungal infections after autologous hematopoietic stem cell transplantation: 10‐year experience at a European Pediatric Cancer Center
Authors: Linke Christina , Tragiannidis Athanasios , Ahlmann Martina , Fröhlich Birgit , Wältermann Maria , Burkhardt Birgit , Rossig Claudia , Groll Andreas H. 
Published: July 2019

SummaryBackgroundAutologous hematopoietic stem cell transplantation (HSCT) carries risks of infectious morbidity. We analysed epidemiology and management burden associated with invasive fungal diseases (IFDs) in children and adolescents undergoing autologous HSCT.MethodsIn a retrospective, single‐centre observational study, epidemiology and management burden associated with IFDs were analysed in all paediatric cancer patients who underwent autologous HSCT between 2005 and 2014. Clinical, radiographic and microbiological data were assessed up to 100 days post‐transplant. The primary endpoint was the incidence of proven, probable and possible IFDs. Further endpoints included the use of systemic antifungal agents for prevention and management of IFDs; infectious and non‐infectious comorbidities; and survival until day + 100.ResultsOf 95 patients (median age: 8 years; r, 0.75‐20) underwent 103 HSCT procedures for solid tumours (92) or lymphoma (11). Primary antifungal prophylaxis was administered in 49 procedures (47.5%). No single case of proven/probable IFD was diagnosed. Nine cases (8.7%) fulfilled criteria of possible pulmonary mould infection and received treatment for a median of 14 days (r, 7‐35). In an additional 12 procedures, empiric antifungal therapy with mould active agents was given for a median of 8 days (r, 3‐105). Microbiologically documented non‐fungal infections were observed in 17 procedures, and five patients were transferred to the ICU. There was one death from biopsy documented toxic endothelial damage at day 83 post‐transplant.ConclusionsAutologous HSCT for solid tumours or lymphoma was associated with low morbidity from IFDs. However, utilisation of systemic antifungal agents for prevention and management of suspected IFDs was considerable.
Tissue typing for kidney transplantation for the general nephrologist
Authors: Mulley William R , Hudson Fiona , Lee Darren , Holdsworth Rhonda F 
Published: July 2019

ABSTRACTTissue typing is the process by which an individual's human leukocyte antigens (HLA) are determined. In transplantation, this vital process allows the immunologic or rejection risk of a donor–recipient pairing to be assessed through reviewing their HLA matching and whether any anti‐HLA antibodies present in recipient serum are donor specific. Tissue typing has increased in sophistication over time which has allowed a deeper appreciation of the antigenically important parts of HLA and increased the complexity of determining immunologic risk.
Genome‐wide identification of EMBRYO‐DEFECTIVE (EMB) genes required for growth and development in Arabidopsis
Authors: Meinke David W. 
Published: July 2019

SummaryWith the emergence of high‐throughput methods in plant biology, the importance of long‐term projects characterized by incremental advances involving multiple laboratories can sometimes be overlooked. Here, I highlight my 40‐year effort to isolate and characterize the most common class of mutants encountered in Arabidopsis (Arabidopsis thaliana): those defective in embryo development. I present an updated dataset of 510 EMBRYO‐DEFECTIVE (EMB) genes identified throughout the Arabidopsis community; include important details on 2200 emb mutants and 241 pigment‐defective embryo (pde) mutants analyzed in my laboratory; provide curated datasets with key features and publication links for each EMB gene identified; revisit past estimates of 500–1000 total EMB genes in Arabidopsis; document 83 double mutant combinations reported to disrupt embryo development; emphasize the importance of following established nomenclature guidelines and acknowledging allele history in research publications; and consider how best to extend community‐based curation and screening efforts to approach saturation for this diverse class of mutants in the future. Continued advances in identifying EMB genes and characterizing their loss‐of‐function mutant alleles are needed to understand genotype‐to‐phenotype relationships in Arabidopsis on a broad scale, and to document the contributions of large numbers of essential genes to plant growth and development.
“What a nurse suffers”: Care left undone in seventeenth‐century Madrid
Authors: Langtree Tanya , Birks Melanie , Biedermann Narelle 
Published: July 2019

AbstractCare left undone, interchangeably referred to as missed care, unfinished nursing care and task incompletion, is pervasive in contemporary healthcare systems. Care left undone can result in adverse outcomes for the patient, nurse and organization. The rhetoric that surrounds care left undone infers it is a contemporary nursing phenomenon; however, a seventeenth‐century Spanish nursing treatise, Instruccion de Enfermeros (Instructions for Nurses), challenges this assumption. Instruccion de Enfermeros was an instructional guide that was written for members of the Congregation of Bernardino de Obregon who worked as nurses at the Madrid General Hospital. The treatise provides a historical commentary on the daily roles, responsibilities and working conditions of the Obregonian nurses. Its content and context suggest the Obregonian nursing resource was consistently time poor due to a confluence of internal and external stressors. Consequently, the Obregonians were under considerable role strain resulting in inferior patient care. This article explores the antecedents of care left undone through a historical lens using exemplars from the 1625 edition of Instruccion de Enfermeros. Factors contributing to care left undone in Obregonian nursing will then be examined to offer insights into the similarities between what a nurse suffered 400 years ago and what exists in contemporary nursing practice.
Is the YouTube™ an useful source of information on oral leukoplakia?
Authors: Kovalski Luan Nathiel Santana , Cardoso Fernanda Brochier , D’Avila Otávio Pereira , Corrêa Ana Paula Borngräber , Martins Marco Antonio Trevizani , Martins Manoela Domingues , Carrard Vinicius Coelho 
Published: July 2019

AbstractObjectivesYouTube™ has become a widely used source of health information. This cross‐sectional study aimed to analyze the quality of English language videos on oral leukoplakia available on YouTube™.Materials and methodsA YouTube™ search for oral leukoplakia was performed, leading to 1,690 videos. The first 100 results were examined for exclusion criteria, yielding 28 videos. The source, duration, views, likes, and dislikes of each video were recorded. Two oral medicine residents scored the videos for visibility, popularity, quality, utility, and reliability.ResultsVideos were categorized into two groups: independent users or company advertisements (n = 21) and professional organizations or government agencies (n = 5). Analysis showed that, in general, videos were of low quality, usefulness, and reliability. Higher quality videos had more likes (p < .05, Mann–Whitney test). More reliable videos received more likes and presented a higher viewing rate and interaction index (p < .05, Mann–Whitney test).ConclusionsThere are few high‐quality videos about oral leukoplakia on YouTube™. Oral medicine professionals and students should attempt to correct this deficit, as they are the holders of evidence‐based knowledge and clinical experience.
Twenty‐four hour ocular and systemic diurnal rhythms in children
Authors: Ostrin Lisa A. , Jnawali Ashutosh , Carkeet Andrew , Patel Nimesh B. 
Published: July 2019

AbstractPurposeOcular diurnal rhythms have been implicated in myopia, glaucoma, diabetes, and other ocular pathologies. Ocular rhythms have been well described in adults; however, they have not yet been fully examined in children. The goal of this study was to investigate ocular and systemic diurnal rhythms over 24 h in children.MethodsSubjects, ages 5 to 14 years (n = 18), wore a light, sleep, and activity monitor for one week to assess habitual sleep/wake patterns, then underwent diurnal measurements every 4 h for 24 h. Measurements included blood pressure, heart rate, body temperature, intraocular pressure (IOP), ocular biometry, and optical coherence tomography imaging. Saliva was collected for melatonin and cortisol analysis. Mean ocular perfusion pressure was calculated from IOP and blood pressure. Central corneal thickness, corneal power, anterior chamber depth, lens thickness, vitreous chamber depth, and axial length were determined from biometry. Total retinal thickness, retinal pigment epithelium (RPE) + photoreceptor outer segment thickness, photoreceptor inner segment thickness, and choroidal thickness were determined for a 1 mm diameter centred on the fovea. Subjects’ amplitude and acrophase of diurnal variation for each parameter were determined using Fourier analysis, and mean acrophase was calculated using unit vector averaging.ResultsRepeated measures analysis of variance (ANOVA) showed that all parameters except anterior chamber depth exhibited significant variations over 24 h (p ≤ 0.005 for all). Axial length underwent diurnal variation of 45.25 ± 6.30 μm with an acrophase at 12.92 h, and choroidal thickness underwent diurnal variation of 26.25 ± 2.67 μm with an acrophase at 1.90 h. IOP was approximately in phase with axial length, with a diurnal variation of 4.19 ± 0.50 mmHg and acrophase at 11.37 h. Total retinal thickness underwent a significant diurnal variation of 4.09 ± 0.39 μm with an acrophase at 15.04 h. The RPE + outer segment layer was thickest at 3.25 h, while the inner segment layer was thickest at 14.95 h. Melatonin peaked during the dark period at 2.36 h, and cortisol peaked after light onset at 9.22 h.ConclusionsOcular and systemic diurnal rhythms were robust in children and similar to those previously reported in adult populations. Axial length and IOP were approximately in phase with each other, and in antiphase to choroidal thickness. These findings may have important implications in myopia development in children.
Treatment Outcomes and Mechanisms for an ACT‐Based 10‐Week Interdisciplinary Chronic Pain Rehabilitation Program
Authors: Craner Julia R. , Lake Eric S. , Bancroft Kimberly A. , George Logan L. 
Published: July 2019

AbstractBackgroundInterdisciplinary pain rehabilitation programs are an evidence‐based biopsychosocial treatment approach for chronic pain. The purpose of the current study is to assess outcomes for a 10‐week interdisciplinary, acceptance and commitment therapy (ACT)‐based, outpatient treatment model and to evaluate the relationship between psychological process variables (ie, pain catastrophizing, pain acceptance, pain self‐efficacy) and treatment outcomes.Methods137 adults with chronic pain completed an interdisciplinary pain rehabilitation program. Measures of pain, pain interference, health‐related quality of life, anxiety, depressed mood, insomnia, pain catastrophizing, pain acceptance, and pain self‐efficacy were completed at admission and discharge. Data were also collected on demographic and clinical variables, including opioid use.ResultsResults indicated significant changes in all measures at program discharge compared to admission. Opioid doses were also reduced. Results of within‐subjects meditational analyses indicated that pain catastrophizing accounted for a significant portion of the treatment effect for pain severity, pain interference, and depressed mood. Pain acceptance was a mediator for change in depressed mood, whereas pain self‐efficacy was a mediator for pain interference outcomes.ConclusionsThis study supports a 10‐week, ACT‐based treatment model for interdisciplinary chronic pain rehabilitation. In addition, pain catastrophizing, pain acceptance, and pain self‐efficacy were each found to be mechanisms by which individuals achieve successful treatment outcomes. This research provides further support for interdisciplinary rehabilitation approaches for chronic pain.
Carbon isotopic tracing of sugars throughout whole‐trees exposed to climate warming
Authors: Furze Morgan E. , Drake John E. , Wiesenbauer Julia , Richter Andreas , Pendall Elise 
Published: July 2019

AbstractTrees allocate C from sources to sinks by way of a series of processes involving carbohydrate transport and utilization. Yet these dynamics are not well characterized in trees, and it is unclear how these dynamics will respond to a warmer world. Here, we conducted a warming and pulse‐chase experiment on Eucalyptus parramattensis growing in a whole‐tree chamber system to test whether warming impacts carbon allocation by increasing the speed of carbohydrate dynamics. We pulse‐labelled large (6‐m tall) trees with 13C‐CO2 to follow recently fixed C through different organs by using compound‐specific isotope analysis of sugars. We then compared concentrations and mean residence times of individual sugars between ambient and warmed (+3°C) treatments. Trees dynamically allocated 13C‐labelled sugars throughout the aboveground‐belowground continuum. We did not, however, find a significant treatment effect on C dynamics, as sugar concentrations and mean residence times were not altered by warming. From the canopy to the root system, 13C enrichment of sugars decreased, and mean residence times increased, reflecting dilution and mixing of recent photoassimilates with older reserves along the transport pathway. Our results suggest that a locally endemic eucalypt was seemingly able to adjust its physiology to warming representative of future temperature predictions for Australia.
Impact of web‐based learning for health program planning competency, knowledge and skills among mid‐level public health nurses: A randomized controlled trial
Authors: Yoshioka‐Maeda Kyoko , Shiomi Misa , Katayama Takafumi , Hosoya Noriko 
Published: July 2019

AbstractObjectivesTo evaluate the impact of web‐based learning modules for health program planning competency, recognition, knowledge and skills among mid‐level public health nurses (PHNs).DesignParallel‐group randomized controlled trial.SampleDuring 2018, 244 Japanese PHNs were eligible as participants with 5–20 years experiences as a PHN were randomly allocated to the intervention (n = 121) or control group (n = 123).MeasurementsThe outcome was assessed using the Competency Measurement of Creativity for PHNs (CMC) and 26 questions about recognition, knowledge, and skills for health program planning.InterventionsEight web‐based modules.ResultsNo significant differences in CMC scores between the control and intervention groups at base line and post‐intervention. By contrast, significant differences in total score of the 26 items of knowledge and skills. In an exploratory analysis, there was a significant difference identified in CMC scores in the demographic of post graduate training in program planning at base line and post‐intervention. (p = .034).ConclusionsThe findings suggested that web‐based learning with flexibility in terms of time and location would improve competency, skills and knowledge of health program planning among mid‐level PHNs.
Pattern of changes in salicylic acid‐induced protein kinase (SIPK) gene expression and salicylic acid accumulation in wheat under cadmium exposure
Authors: Tajti J. , Németh E. , Glatz G. , Janda T. , Pál M. 
Published: July 2019

Abstract

Salicylic acid‐induced protein kinase (SIPK) is known as a ‘master switch’ for stress responses in plants. It can be induced by salicylic acid (SA) and several stress factors. The main aim of the present study was to reveal the relationship between SA accumulation and the gene expression level of SIPK during 50 and 250 µm Cd stress in wheat plants.

Quantitative real‐time PCR was used for determination of the gene expression level of SIPK. Salicylic acid content measurement was performed with an HPLC system equipped with a fluorescence detector.

Cadmium treatment increased the endogenous SA level and expression level of SIPK in a concentration‐dependent manner. Induction of SIPK expression preceded the accumulation of endogenous SA. Although SA treatment induced dramatic endogenous SA accumulation, its SIPK‐inducing effect was moderate. In roots, higher induction of SIPK was observed than in leaves. The same tendency of SIPK expression was observed in both Cd‐ and SA‐treated plants, as decisively the highest transcript level was detected after 30 min of treatment, but thereafter the expression decreased rapidly to control level or even below.

The induction of SIPK was transient in all cases, and even a very high SA level in either the leaves or roots was not able to maintain the elevated expression level of this gene. The results suggest that SIPK has a role in initiating Cd stress response and the exogenous SA‐induced signalling process.
The ecological cocktail party: Measuring brain activity during an auditory oddball task with background noise
Authors: Scanlon Joanna E. M. , Cormier Danielle L. , Townsend Kimberley A. , Kuziek Jonathan W. P. , Mathewson Kyle E. 
Published: July 2019

AbstractMost experiments using EEG recordings take place in highly isolated and restricted environments, limiting their applicability to real‐life scenarios. New technologies for mobile EEG are changing this by allowing EEG recording to take place outside of the laboratory. However, before results from experiments performed outside the laboratory can be fully understood, the effects of ecological stimuli on brain activity during cognitive tasks must be examined. In this experiment, participants performed an auditory oddball task while also listening to concurrent background noises of silence, white noise, and outdoor ecological sounds, as well as a condition in which the tones themselves were at a low volume. We found a significantly increased N1 and decreased P2 when participants performed the task with outdoor sounds and white noise in the background, with the largest differences in the outdoor sound condition. This modulation in the N1 and P2 replicates what we have previously found outside while people rode bicycles. No behavioral differences were found in response to the target tones. We interpret these modulations in early ERPs as indicative of sensory filtering of background sounds and that ecologically valid sounds require more filtering than simple synthetic sounds. Our results reveal that much of what we understand about the brain will need to be updated as cognitive neuroscience research begins to step outside of the lab.
Stressing the accuracy: Wrist‐worn wearable sensor validation over different conditions
Authors: Menghini Luca , Gianfranchi Evelyn , Cellini Nicola , Patron Elisabetta , Tagliabue Mariaelena , Sarlo Michela 
Published: July 2019

AbstractWearable sensors are promising instruments for conducting both laboratory and ambulatory research in psychophysiology. However, scholars should be aware of their measurement error and the conditions in which accuracy is achieved. This study aimed to assess the accuracy of a wearable sensor designed for research purposes, the E4 wristband (Empatica, Milan, Italy), in measuring heart rate (HR), heart rate variability (HRV), and skin conductance (SC) over five laboratory conditions widely used in stress reactivity research (seated rest, paced breathing, orthostatic, Stroop, speech task) and two ecological conditions (slow walking, keyboard typing). Forty healthy participants concurrently wore the wristband and two gold standard measurement systems (i.e., electrocardiography and finger SC sensor). The wristband accuracy was determined by evaluating the signal quality and the correlations with and the Bland‐Altman plots against gold standard‐derived measurements. Moreover, exploratory analyses were performed to assess predictors of measurement error. Mean HR measures showed the best accuracy over all conditions. HRV measures showed satisfactory accuracy in seated rest, paced breathing, and recovery conditions but not in dynamic conditions, including speaking. Accuracy was diminished by wrist movements, cognitive and emotional stress, nonstationarity, and larger wrist circumferences. Wrist SC measures showed neither correlation nor visual resemblance with finger SC signal, suggesting that the two sites may reflect different phenomena. Future studies are needed to assess the responsivity of wrist SC to emotional and cognitive stress. Limitations and implications for laboratory and ambulatory research are discussed.
Sustainable aquaculture requires environmental‐friendly treatment strategies for fish diseases
Authors: Lieke Thora , Meinelt Thomas , Hoseinifar Seyed Hossein , Pan Bo , Straus David L. , Steinberg Christian E. W. 
Published: July 2019

AbstractMany classical therapeutants are going to be banned in Europe, and an urgent need for alternatives is emerging. This issue can be exemplified by one major parasitic disease in aquaculture and ornamental fish breeding: velvet disease. This disease, caused by dinoflagellates of the genera Amyloodinium and Piscinoodinium, is an important infection affecting cultured freshwater and marine ornamental and food fish, and consistently causes great financial loss to the associated industries. Therapeutants available contain copper, malachite green, or methylene blue, and which can be toxic to non‐target organisms in the surrounding environment. As a result, these chemicals are banned for use by the aquaculture industry in several countries, and a prohibition for commercial ornamental fishkeeping is likely to follow in most countries. Increasing development of resistance to therapeutants, and growing public awareness for animal welfare and environmental protection, have prompted research in the areas of alternative treatment options and immunostimulants. Hydrogen peroxide and peracetic acid are possible ‘green’ therapeutants which do not contribute residues to the environment. Natural feed supplements such as pre‐ and probiotics can increase animal welfare and prevent stress and/or infections. Humic substances are another promising, natural immunostimulants which will be considered in depth. The aim of this review is to provide an overview of risks and benefits of current treatment options and new approaches to replace harmful therapeutants and minimize the number of toxic residues discharged into the environment. Treatments will be discussed on various parasitic infections and focus, where available, on Amyloodinium and Piscinoodinium.
Predication and cognitive context: Between minimalism and contextualism
Authors: Balletta Sandro , Domaneschi Filippo 
Published: July 2019

AbstractIn this paper, we suggest a strategy for modelling cognitive context within a truth‐conditional semantics, using Asher's model of predication. This allows us to introduce the notion of type presupposition intended as a lexical constraint to the composition of the truth‐conditional content. More specifically, we suggest that this model of predication produces a notion of truth‐conditional meaning where the cognitive context fixes a set of lexical restrictions and forced modifications. We conclude that this model might offer an intermediate position between Minimalism and Contextualism: an account that provides intuitive truth conditions within a formal semantic theory.