bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instability of energy solutions, travelling waves, and scaling invariance for a fourth-order p-Laplacian operator with superlinear reaction
Authors: Diaz Palencia Jose Luis 
Published: November 2024

This analysis explores the oscillatory behavior of traveling wave solutions for a higher-order p-Laplacian operator with a superlinear reaction term. The study employs an energy-based approach, incorporating generalized Sobolev spaces to examine relevant properties of the solutions, including oscillations, diffusive mollification, and compact support. Based on this energy framework, the regularity of the involved operator is established. The problem is then reformulated using a traveling wave approach, revealing the oscillatory nature of solutions near the null solution. Numerical simulations are conducted for each wave speed to validate the analytical results, yielding the corresponding traveling profiles. Notably, one of the most significant findings is the attraction towards the null critical point, which helps prevent blow-up formation. Finally, the study delves into the equation's scale-invariant properties, leading to the derivation of self-similar solutions.
For more information see https://ejde.math.txstate.edu/Volumes/2024/68/abstr.html
Prevalência das coagulopatias hereditárias e demais transtornos hemorrágicos por diagnostico no Brasil em 2022
Authors: Da Silva Leticia , Sousa Kelli , Keller Joao , Garcia Ellen 
Published: November 2024

Título: Prevalência das coagulopatias hereditárias e demais transtornos hemorrágicos por diagnóstico no Brasil em 2022.
Autores: Ellen Vilanova Alvez Garcia, Joao Paulo Demarqui Keller, Kelli Hellen De Souza e Leticia Cristina Da Silva.

Instituição: Universidade do Oeste Paulista (Unoeste), SP, Brasil;

Objetivos: Demonstrar o levantamento quantitativo de indivíduos que apresentam coagulopatias hereditárias no Brasil, durante o ano de 2022.O Objetivo específico é apresentar a patologia de maior recorrência mediante os demais transtornos hemorrágicos.

Material e Métodos: Pesquisas primarias e secundarias foram utilizadas para o desenvolvimento do trabalho, incluindo artigos científicos, metanálise e revisão literária e métodos de pesquisas online de websites como, Scielo, Google acadêmico, Biblioteca Virtual em Saúde (BVS), demais literaturas de livros, revistas e Sistema de Coagulopatia HemovidaWEB, disponibilizando dados dos portadores do distúrbio.

Resultados: Em 2022, no Sistema Único de Saúde (SUS) no Brasil, foram diagnosticados 31.025 pacientes portadores de algum tipo de coagulopatias hereditárias. Sua maior recorrência são portadores de hemofilia do tipo e tipo B, em segundo lugar a doença de Von Willebrand, posteriormente seguindo para coagulopatias raras e por fim e outras coagulopatias hereditárias e aos demais transtornos hemorrágicos. O tratamento indicado para pessoas portadoras dos distúrbios hemorrágicos se baseia na restituição do fator deficiente, disponibilizado gratuitamente no Sistema Único de Saúde (SUS), contando com consultas, exames, acompanhamentos, medicamentos, todo cuidado apropriado.
Discussão: A maior ocorrência de casos voltados as coagulopatias e demais transtornos hemorrágicos em 2022 no Brasil, foram a Unidade Federativa (UF) do Sudeste. Englobando as patologias voltadas a esses transtornos, a cidade de São Paulo possui o maior índice de portadores.
Posteriormente seguindo para a (UF) do Nordeste, Sul, Centro Oeste e Norte.

Conclusão: O estado de São Paulo, como observado, possui o nível superior de registro de casos, esse fato pode estar atribulado as informações que são de fácil acesso, número habitacional e com renomados hospitais e hemocentros classificados como um dos melhores do país. Esses dados são essenciais para a formulação de políticas públicas voltadas ao diagnóstico precoce e ao tratamento adequado dessas condições. Além disso, a conscientização sobre a importância do diagnóstico e do tratamento precoce é fundamental para melhorar a qualidade de vida dos pacientes e reduzir as complicações associadas. O estudo destaca a necessidade contínua de investimentos em saúde e educação para garantir que pacientes com coagulopatias hereditárias recebam o tratamento necessário e que novos casos sejam identificados e tratados prontamente.
TINJAUAN HUKUM TERHADAP PERLINDUNGAN KONSUMEN DALAM LAYANAN SHOPEE PAY LATER
Authors: Nadya Ivi Oktaviani  , Rifchyka Putri Hermawan  , Cita Rahma Utami  
Published: November 2024

Abstract. This research examines aspects of consumer legal protection in the Shopee Pay Later (SPayLater) service, which is part of the rapidly growing fintech trend in Indonesia. Along with the increasing use of digital credit services such as Pay Later, the issue of consumer protection is becoming increasingly crucial. The role of the Financial Services Authority (OJK) and Bank Indonesia (BI) in ensuring that Shopee Pay Later complies with existing regulations and provides protection for its consumers. Using a normative juridical approach, this research evaluates the regulations in Indonesia that govern digital credit services, including the consumer protection law and OJK regulations. In addition, this study also highlights the role of financial institutions in providing fair and transparent credit solutions for consumers caught in default situations. It can be concluded that strict supervision, information transparency, and personal data protection are important aspects in providing legal protection for consumers of Shopee Pay Later services. Keywords: Shopee Pay Later, Consumer Protection, Financial Services Authority, Bank Indonesia.

Abstrak. Penilitian ini mengkaji aspek perlindungan hukum konsumen dalam layanan Shopee Pay Later (SPayLater), yang menjadi bagian dari tren fintech yang berkembang pesat di Indonesia. Seiring dengan meningkatnya penggunaan layanan kredit digital seperti Pay Later, persoalan perlindungan konsumen menjadi semakin krusial. Peran Otoratis Jasa Keuangan (OJK) dan Bank Indonesia (BI) dalam memastikan bahwa Shopee Pay Later memathui regulasi yang ada serta memberikan perlindungan bagi konsumennya. Dengan pendekatan yuridis normatif, penilitian ini mengevaluasi peraturan-peraturan di Indonesia yang mengatur layanan kredit digital, termasuk Undang-Undang perlindungan konsumen dan aturan ojk. Selain itu, dalam penelitian ini juga menyoroti peran lembaga keuangan dalam memberikan solusi kredit yang adil dan transparan bagi konsumen yang terjebak dalam situasi gagal bayar. Dapat di simpukan bahwa pengawasan yang ketat, tranparansi informasi, dan perlindungan data pribadi merupakan aspek penting dalam memberikan perlindungan hukum bagi konsumen layanan Shopee Pay Later.

Kata Kunci: Shopee Pay Later, Perlindungan Konsumen, Otoritas Jasa Keuangan, Bank Indonesia
Plataformas ODR como alternativa de resolução de litígios trabalhistas no Brasil
Authors: Silveira Bruno Furtado 
Published: November 2024

Este artigo tem como principal objetivo analisar as possibilidades de utilização de plataformas digitais, também chamadas pelo acrônimo ODR (online dispute resolution), como uma ferramenta extrajudicial de resolução de conflitos e, mais especificamente, como um mecanismo para resolver litígios trabalhistas. Nessa temática, ganha destaque iniciativas do Conselho Nacional de Justiça (CNJ), órgão que, além de incentivar a autocomposição, determinou que os Tribunais brasileiros criem sistemas digitais de solução de controvérsias, chamados de SIREC, que possuem diversas semelhanças com as plataformas ODR. As mencionadas plataformas ODR têm a finalidade de solucionar litígios antes mesmo que estes resultem em ações judiciais. Serão abordados os desafios para a implementação de plataformas ODR para a solução de litígios trabalhistas no Brasil, como os relacionados à imparcialidade do processo, vieses algorítmicos, adaptação às peculiaridades das normas trabalhistas brasileiras e abrangência da quitação em um eventual acordo. O artigo foi desenvolvido por revisão bibliográfica e adota o método hipotético-dedutivo, chegando à conclusão de que seria possível utilizar no Brasil as plataformas ODR para resolver controvérsias relacionadas ao Direito do Trabalho, considerando o modelo multiportas de solução de conflitos.
Meninjau Ulang Perspektif Hidup Berkelimpahan Dan Hidup Berkekurangan Dalam Konteks Doa Orang Kristen
Authors: Timbuleng Nontje Mery 
Published: November 2024

Artikel ini bertujuan untuk meninjau ulang perspektif hidup berkelimpahan dan hidup berkekurangan dalam konteks doa orang Kristen, dengan fokus pada peran doa dalam membentuk sikap spiritual dan pemahaman umat terhadap dua keadaan tersebut. Masalah dalam praktik iman Kristen, banyak orang merasa bingung antara menjalani hidup berkelimpahan yang diasosiasikan dengan berkat materi dan hidup berkekurangan yang sering dianggap sebagai ujian. Ketegangan antara kedua perspektif ini dapat memengaruhi cara umat berdoa dan berinteraksi dengan Tuhan serta sesama. Penelitian ini menggunakanmetode pendekatan kualitatif dengan analisis teologis terhadap teks-teks Alkitab, literatur spiritual, dan wawancara mendalam dengan praktisi iman. Dengan demikian, artikel ini mengumpulkan berbagai pandangan dan pengalaman umat Kristen mengenai doa dalam konteks kelimpahan dan kekurangan. Hasil yang hendak dicapai bahwa doa berfungsi sebagai jembatan yang menghubungkan umat dengan Tuhan dalam berbagai keadaan. Dalam hidup berkelimpahan, doa menciptakan kesadaran akan tanggung jawab sosial dan pentingnya bersyukur. Sebaliknya, dalam hidup berkekurangan, doa menjadi sumber penguatan dan pengharapan, membantu individu untuk tetap percaya akan pemeliharaan Tuhan.Akhir dari artikel ini adalah sebuah kesimpulan yang memberi penegasan mengenai hasil penelitian yang dicapai.
A (in)constitucionalidade da taxa zero para microempreendedores individuais: entre o tratamento favorecido às microempresas e a autonomia municipal
Authors: Corralo Giovani da Silva , Blum Fernando 
Published: November 2024

A presente pesquisa aborda a constitucionalidade da política de taxa zero para os microempreendedores individuais prevista na LC 123/06, a perscrutar se a imposição de tal obrigação para os entes municipais fere a autonomia local. Para tanto, discorre-se sobre a ordem econômica brasileira e o tratamento favorecido e privilegiado às micro e pequenas empresas, o que requer a compreensão da ordem constitucional e da LC 123/06. Na sequência analisa-se a autonomia municipal e as decisões dos tribunais sobre o tema, contraditórias, aliás. Conclui-se pela constitucionalidade da política de taxa zero aos microempreendedores individuais prevista no §3.º do art. 4.º, a incidir sobre todos os entes que integram a Federação, inclusive os Municípios, por se tratar de norma geral albergada pelo art. 146, III, “d”, da Constituição Federal, que concretiza o regime único de tributação às micro e pequenas empresas.
The impact of hsa-miR-1972 on the expression of von Willebrand factor in breast cancer progression regulation
Authors: Yu Changjiang , Zhang Tao , Chen Fan , Yu Zhenyang 
Published: November 2024

Background
Breast cancer (BC) is one of most frequent female malignancies that poses multiple challenges in treatment and prevention. This study aimed to explore the role of miRNAs and their target genes during the BC progression.

Methods
Based on the BC data (113 normal and 1,118 tumor samples) from the TCGA-BRCA dataset, a single-sample gene set enrichment analysis (ssGSEA) was applied to calculate the cancer migration scores, and weighted gene co-expression network analysis (WGCNA) were performed using the WGCNA R package, with a focus on the set of genes associated with cancer migration. Key modules and hub genes related to cell migration and signaling pathways were identified. Survival analysis of hub genes was conducted using the survminer R package, and prediction of regulatory miRNAs were performed to analyze their impact on BC prognosis. In addition, the BC cell lines MCF-7 and MDA-MB-231 were used to further explore the effect of hsa-miR-1972 mimics on the gene expression and angiogenic factor regulation.

Results
The study classified important modules (MEblue, MEmagenta, MEpink, and MEfloralwhite) associated with cell migration and identified three hub genes, namely, MRPL20, COL4A1 and VWF. Survival analysis showed that certain hub genes with a low expression were related to a poor prognosis, whereas low-expressed COL4A1 and VWF were related to better survival outcomes. We also found that hsa-miR-1972 mimics significantly downregulated critical genes involved in BC metastasis and angiogenesis and effectively inhibited the proliferation of BC cell lines, showing a strong therapeutic potential. Manipulation of VWF expression in cells overexpressing hsa-miR-1972 had significant effects on the malignant markers and angiogenic factors, suggesting a novel therapeutic direction for BC treatment.

Conclusion
Our study highlighted the complex interplay of genetic factors in BC progression as well as the therapeutic potential of targeting specific miRNAs and their related hub genes. These findings provided novel insights into the pathogenesis of BC and suggested new direction for the therapeutic development for the cancer.
Evaluating Insect Abundance and Diversity in Organic Farming using Solar and LED Light Traps for Sustainable Pest Management
Authors: N. Shreya , Mulimani Vidya , N. Sumithramma , Kumar A. R. V. 
Published: November 2024

An experiment on comparison of two different light traps in an organic farming system was conducted in J-block of Gandhi Krishi Vignana Kendra (GKVK) maintained by the Research Institute on Organic Farming (RIOF), University of Agricultural Sciences, Bengaluru, Karnataka, India to understand the abundance and diversity of insects caught in a Solar light trap and an electric White LED light trap. The study was conducted for 7 months from February 2022 to August 2022 in 14 days intervals. In Solar light trap, among the total of 4713 insects collected, order Coleoptera ranked first with 3222 insects (68.36% of the total insects). In the White LED light trap, among 2795 insects collected, order Hymenoptera ranked first with 828 specimens (30% of total insects caught). In Solar light trap, among the different insect orders, Coleoptera included the highest number of operational taxonomic units (38 OTUs) contributing to 45% of the total number of OTUs caught, followed by the order Hemiptera with 26 OTUs contributing to 31%. In the White LED light trap, Hemiptera included the highest number of OTUs (43 OTUs) contributing to 41% of the total number of OTUs followed by the order Coleoptera with 25 OTUs (24%). The diversity indices for the number of insects, OTUs and families were highest in the white led light trap compared to the solar light trap and the white led light trap caught less total number of insects but with more diversity, on contradictory the solar light trap trapped a greater number of insects but with less diversity.
Validation and clinical implementation of an accurate Monte Carlo code for pencil beam scanning proton therapy
Authors: Huang Sheng , Kang Minglei , Souris Kevin , Ainsley Christopher , Solberg Timothy D. , McDonough James E. , Simone Charles B. , Lin Liyong 
Published: July 2018

AbstractMonte Carlo (MC)‐based dose calculations are generally superior to analytical dose calculations (ADC) in modeling the dose distribution for proton pencil beam scanning (PBS) treatments. The purpose of this paper is to present a methodology for commissioning and validating an accurate MC code for PBS utilizing a parameterized source model, including an implementation of a range shifter, that can independently check the ADC in commercial treatment planning system (TPS) and fast Monte Carlo dose calculation in opensource platform (MCsquare). The source model parameters (including beam size, angular divergence and energy spread) and protons per MU were extracted and tuned at the nozzle exit by comparing Tool for Particle Simulation (TOPAS) simulations with a series of commissioning measurements using scintillation screen/CCD camera detector and ionization chambers. The range shifter was simulated as an independent object with geometric and material information. The MC calculation platform was validated through comprehensive measurements of single spots, field size factors (FSF) and three‐dimensional dose distributions of spread‐out Bragg peaks (SOBPs), both without and with the range shifter. Differences in field size factors and absolute output at various depths of SOBPs between measurement and simulation were within 2.2%, with and without a range shifter, indicating an accurate source model. TOPAS was also validated against anthropomorphic lung phantom measurements. Comparison of dose distributions and DVHs for representative liver and lung cases between independent MC and analytical dose calculations from a commercial TPS further highlights the limitations of the ADC in situations of highly heterogeneous geometries. The fast MC platform has been implemented within our clinical practice to provide additional independent dose validation/QA of the commercial ADC for patient plans. Using the independent MC, we can more efficiently commission ADC by reducing the amount of measured data required for low dose “halo” modeling, especially when a range shifter is employed.
A study of minimum segment width parameter on VMAT plan quality, delivery accuracy, and efficiency for cervical cancer using Monaco TPS
Authors: Wang Yuanyuan , Chen Li , Zhu Fengying , Guo Wanjing , Zhang Dandan , Sun Wenzhao 
Published: July 2018

AbstractPurposeThe purpose of this study was to study the influence of the minimum segment width (MSW) on volumetric modulated arc therapy (VMAT) plan quality, delivery accuracy, and efficiency for cervical cancer treatment.MethodsNineteen patients with cervical cancer were randomly selected to design VMAT plans. Three VMAT plans were generated for each patient incorporating MSWs of 0.5, 1.0, and 1.5 cm while other planning parameters remained constant using the Monaco treatment planning system (TPS) with 6 MV X rays delivered from an Elekta Synergy linear accelerator. Plan quality and delivery efficiency were evaluated based on dose‐volume histograms (DVHs), control points, monitor units (MUs), dosimetric measurement verification results, and plan delivery time.ResultsExcept for the small difference in target dose coverage and maximum dose, there were no statistically significant differences between the other dosimetric parameters in the planning target volumes. The 1.0 and 1.5 cm MSW plans showed lower maximum doses to the spinal cord than the 0.5 cm plan; doses to other organs at risks were similar regardless of MSWs. The mean reductions of total MUs when compared with the 0.5 cm plan were 14.5 ± 6.1% and 20.9 ± 7.9% for MSWs of 1.0 and 1.5 cm, respectively. The calculated gamma indices using the 3% and 3 mm criteria were 96.2 ± 0.6%, 97.0 ± 0.6%, and 97.6 ± 0.6% for the 0.5, 1.0 and 1.5 cm MSW plans, respectively. The plan delivery times decreased with increasing MSWs (p < 0.05).ConclusionIncreasing the MSW allows for improved plan delivery accuracy and efficiency without significantly affecting the VMAT plan quality. MSWs of 1.0 and 1.5 cm improved the plan quality, delivery accuracy, and efficiency for cervical VMAT radiation therapy.
Flexible Thermoelectric Polymer Composites Based on a Carbon Nanotubes Forest
Authors: Yusupov Khabib , Stumpf Steffi , You Shujie , Bogach Aleksei , Martinez Patricia M. , Zakhidov Anvar , Schubert Ulrich S. , Khovaylo Vladimir , Vomiero Alberto 
Published: July 2018

AbstractPolymer‐based composites are of high interest in the field of thermoelectric (TE) materials because of their properties: abundance, low thermal conductivity, and nontoxicity. In applications, like TE for wearable energy harvesting, where low operating temperatures are required, polymer composites demonstrate compatible with the targeted specifications. The main challenge is reaching high TE efficiency. Fillers and chemical treatments can be used to enhance TE performance of the polymer matrix. The combined application of vertically aligned carbon nanotubes forest (VA‐CNTF) is demonstrated as fillers and chemical post‐treatment to obtain high‐efficiency TE composites, by dispersing VA‐CNTF into a poly (3,4‐ethylenedioxythiophene) polystyrene sulfonate matrix. The VA‐CNTF keeps the functional properties even in flexible substrates. The morphology, structure, composition, and functional features of the composites are thoroughly investigated. A dramatic increase of power factor is observed at the lowest operating temperature difference ever reported. The highest Seebeck coefficient and electrical conductivity are 58.7 µV K−1 and 1131 S cm−1, respectively. The highest power factor after treatment is twice as high in untreated samples. The results demonstrate the potential for the combined application of VA‐CNTF and chemical post‐treatment, in boosting the TE properties of composite polymers toward the development of high efficiency, low‐temperature, flexible TEs.
Hydrophobic and Electronic Properties of the E‐MoS2 Nanosheets Induced by FAS for the CO2 Electroreduction to Syngas with a Wide Range of CO/H2 Ratios
Authors: Lv Kuilin , Teng Chao , Shi Minhao , Yuan Yi , Zhu Ying , Wang Jingrong , Kong Zhuang , Lu Xianyong , Zhu Ying 
Published: July 2018

AbstractThe electrochemical CO2 reduction reaction (CO2RR) to produce CO and H2 (syngas) is a promising method for clean energy, but challenges remain, such as controlling the CO/H2 ratios required for the syngas yield. Herein, hydrophobic exfoliated MoS2 (H‐E‐MoS2) nanosheets are fabricated from bulk MoS2 by a cost‐effective ball‐milling method, followed by decoration with fluorosilane (FAS). H‐E‐MoS2 is a cost‐effective electrocatalyst capable of directly reducing CO2 and H2O for tuneable syngas production with a wide range of CO/H2 ratios (from 1:2 to 4:1). In addition, H‐E‐MoS2 shows a high current density, 61 mA cm−2 at −1.1 V, and the highest CO FE of 81.2% at −0.9 V, which are higher than those of unmodified MoS2. According to density functional theory calculations, FAS decoration on the surface of MoS2 electrode can change the electronic properties of the edge Mo atom, which facilitates the rate‐limiting CO‐desorption step, thus promoting CO2RR. Moreover, the hydrophobic surface of H‐E‐MoS2 depressed the H2 evolution reaction and created abundant three‐phase contact points that provided sufficient CO2. The hydrophobization of the electrode may provide an effective strategy for easily tuning the CO/H2 ratio of syngas in a large range for the direct electroreduction CO2 to syngas with an optimized CO/H2 ratio.