bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualize the time dynamics and research trends of macrophage associated periodontitis research from 2004 to 2023: Bibliometrix analysis
Authors: Zheng Hu , Cai Yuhang , Liu Keyi , Xiang Junwei , Han Wenjia , Wang Yuanyin , Chen Ran 
Published: November 2024

Background:
Macrophages play an important role in the symptoms and structural progression of periodontitis, and are receiving increasing attention. In recent years, research has shown significant progress in macrophage associated periodontitis. However, there is still lack of comprehensive and methodical bibliometric analysis in this domain. Therefore, this research aims to describe the state of the research and current research hotspots of macrophage associated periodontitis from the perspective of bibliometrics.

Methods:
This study collected and screened a total of 1424 articles on macrophage associated periodontitis retrieved between 2004 and 2023 from Web of Science Core Collection database. Use Citespace (6.1. R6), Bibliometrix-R (4.1.3), VOSviewer (1.6.19), and Graphpad Prism8 software to analyze and plot countries/regions, institutions, journals, authors, literature, and keywords to explore the research hotspots and development trends of macrophage associated periodontitis.

Result:
After analysis, the amount of macrophage associated periodontitis publications has been rising consistently over time, with China having the most publications (29.32%). 3 countries accounted for 65.57% of the total publications: the United States, China, and Japan, occupying a dominant position in this research field. China publications have the fastest growth rate and played a driving role. The most productive institution is the Sichuan University in China. Journal of Periodontal Research is highly popular in the field of macrophage associated periodontitis, with the highest number of publications. Grenier, Daniel is the most prolific author. Inflammation and Bone Loss in Periodontal Disease are the most cited literature. “Biological pathogenic factors,” “immune regulation,” “mechanism research,” “susceptibility factor research,” “pathological processes and molecular correlation,” “pathological characteristics,” “inflammatory response” are the main keyword groups in this field.

Conclusion:
This study systematically analyzes and describes the development process, direction, and hotspots of macrophage associated periodontitis using bibliometric methods, providing a reference for future researchers who continue to study macrophage associated periodontitis.
Clinical efficacy of Crinone on pregnancy outcomes in frozen embryo transfer: A retrospective study in the Chinese population
Authors: Xu Lishuang , Xiong Fang , Chen Jie , Jin Xin , Zeng Huiming , Weng Meiling 
Published: November 2024

Background:
The aim of this study was to retrospectively investigate the effect of Crinone vaginal gel on pregnancy outcomes in women undergoing natural cycle (NC) frozen embryo transfer (FET) and to obtain the most suitable population for its routine application.

Methods:
The 1613 women who underwent FET in the NC regimen [including the controlled ovulation stimulation protocol for the natural cycle, or the controlled ovulation stimulation protocol for the natural cycle (NC-COS)] from 2017 to 2021 were included. All patients were divided into 2 groups including Control group and Crinone group, which administered with or without Crinone vaginal gel. The key clinical information and between the 2 groups was recorded in detail.

Results:
The results indicated that there were no statistical differences in blood β human chorionic gonadotropin (HCG) positive rate, clinical pregnancy, live birth, abortion (spontaneous and induced) and stillbirth between Control group and Crinone group. Moreover, Crinone could prevent spontaneous abortion. The spontaneous abortion rate in the Crinone group was 5.93% while this in control group was 8.32%. In the cohort exposed to Femoston, the preventive result was more significant (0/32 vs 5/15, P = .001). Furthermore, Crinone exhibited a significant protective effect on spontaneous abortion in 1520 patients who received no human menopausal gonadotropin (HMG) treatment.

Conclusion:
This study demonstrated that the Crinone could protect women against spontaneous abortion, especially in patients who do not need HMG or in combination with Femoston.
Research hotspots and trends related to pain in gouty arthritis from 2014 to 2024: A bibliometric analysis
Authors: Lu Chengyin , Guo Yuxing , Luo Zhiqiang , Hu Xiaomei , Xiong Hui , Xiang Yang , Shu Yang , Jian Gonghui 
Published: November 2024

Background:
Gouty arthritis is a metabolic condition caused by disordered purine metabolism and elevated uric acid levels. This study adopts a bibliometric approach to analyze current research on pain in gouty arthritis and forecast future research trends.

Methods:
Retrieve relevant research on gouty arthritis pain in the Web of Science core collection database, screen literature, and use visualization software such as CiteSpace, Vosviewers, and R package “Bibliometrix” for analysis.

Results:
The total number of documents included was 1133, with 909 articles and 224 reviews. Between 2014 and 2024, there was an overall upward trend in the number of publications about pain in gouty arthritis, with the United States of America and China ranking first and second, respectively, in terms of publication volume. The UNIVERSITY OF ALABAMA BIRMINGHAM had the most publications, and Professor DALBETH N played a key role in this field. According to the keyword analysis, disease management and treatment, particularly methods for enhancing patients’ quality of life and reducing symptoms, are research hotspots. For a deeper understanding, attention is also being paid to the epidemiology and pathological mechanisms of the disease. Emerging keywords such as “gut microbiota” and “urate-lowering therapies” indicate growing interest in the interrelationship between gut microbiota and gout, and the development of new treatment methods.

Conclusion:
This bibliometric study reveals that research on gouty arthritis pain is actively developing. Current hot topics reflect investigations into the deeper pathological mechanisms of gouty arthritis and the development of new treatment methods, including urate-lowering therapies. There is also increasing attention on the role of gut microbiota in the disease. Despite limitations such as the preliminary nature of research methods and insufficient interdisciplinary collaboration, future research directions aim to improve the rigor of research design, strengthen international cooperation, promote unified treatment guidelines, and optimize the diagnosis and treatment of gouty arthritis with new technologies like artificial intelligence, precision medicine, and nanomedicine. This will drive the field towards a deeper scientific understanding, more effective treatment methods, and more comprehensive disease management, ultimately improving patients’ prognosis and quality of life.
Clinical evaluation of the efficacy of focused extracorporeal shock-wave therapy in patients with cervical spondylosis: A randomized control trial
Authors: Li Shuangyue , Liu Jie , Wang Yan , Zhu Chan , Tang Yahong , Gu Minghong 
Published: November 2024

Background:
Extracorporeal shock wave therapy (ESWT) has emerged as a contemporary modality in physiotherapy, demonstrating efficacy in addressing musculoskeletal disorders. Despite its potential, the clinical efficacy of ESWT in the context of cervical spondylosis remains understudied, with a dearth of robust empirical evidence. To bridge this gap, the present study was designed to evaluate the therapeutic impact of focused ESWT (fESWT) on pain alleviation and functional improvement in individuals afflicted with cervical spondylosis.

Method:
A multicenter, randomized controlled clinical study was conducted, collecting data from 5 clinical studies on the treatment of cervical spondylosis with fESWT from June 2021 to March 2024. The inclusion criteria were patients diagnosed with cervical spondylosis, aged 20 to 70, without severe underlying diseases such as heart disease, hypertension, diabetes, etc. The exclusion criteria included pregnant women, nursing women, patients with bleeding tendencies, or those with cardiac pacemakers. The control group underwent a sham fESWT, while the experimental group received fESWT administered via the Duolith SD1 Tower device. The main observation indicators included the Visual Analogue Scale (VAS) for pain scoring, Neck Disability Index (NDI) scoring, cervical range of motion (ROM) scoring, and the Short Form-36 (SF-36) quality of life survey scoring.

Results:
A total of 320 subjects were included in the study, with 160 in the experimental group and 160 in the control group. Post-treatment, the VAS and NDI scores in the experimental group were significantly lower than those in the control group (P < .05), while the cervical range of motion (ROM) and SF-36 scores were significantly higher than in the control group (P < .05). The overall treatment efficacy rate in the experimental group exceeded 90%, markedly higher than the approximately 70% rate in the control group (P < .05). There was no significant difference in the incidence of adverse reactions between the 2 groups.

Conclusion:
The fESWT has shown promising therapeutic effects in the treatment of cervical spondylosis. It effectively reduces patient pain, improves cervical function, and enhances the quality of life, making it worthy of clinical promotion and application.
Timing of Palliative Care Consultation and End-of-Life Care Intensity in Pediatric Patients With Advanced Heart Disease: Single-Center, Retrospective Cohort Study, 2014–2022
Authors: Songer Kathryn L. , Wawrzynski Sarah E. , Olson Lenora M. , Harousseau Mark E. , Meeks Huong D. , Moresco Benjamin L. , Delgado-Corcoran Claudia 
Published: November 2024

OBJECTIVES:
Pediatric patients with advanced heart disease (AHD) often receive high intensity medical care at the end of life (EOL). In this study, we aimed to determine whether receipt and timing of pediatric palliative care (PPC) consultation was associated with EOL care intensity of pediatric patients with AHD.

DESIGN:
Retrospective cohort study.

SETTING:
Single-center, 16-bed cardiac ICU (CICU) in a children’s hospital in the Mountain West.

PATIENTS:
Pediatric patients (0–21 yr) with AHD treated in the CICU and subsequently died from January 2014 to December 2022.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
We compared demographics, EOL characteristics, and care, including medical interventions and mortality characteristics for patients by receipt and timing of PPC (i.e., ≥ 30 d from [early] or < 30 d of death [late]) using chi-square and Wilcoxon rank-sum tests. Of 218 patients, 78 (36%) did not receive PPC, 76 received early PPC (35%), and 64 received late PPC (29%). Compared with patients who did not receive PPC, patients receiving PPC had lower EOL care intensity (77% vs. 96%; p = 0.004) and fewer invasive interventions within 14 days of death (74% vs. 92%; p = 0.004). Receipt of PPC, vs. not, was associated with lower rate of death during cardiopulmonary resuscitation (12% vs. 32%; p = 0.004) and more use of comfort care (23% vs. 3%; p = 0.004). Among patients receiving PPC, early PPC was associated with fewer invasive interventions within 14 days of death (65% vs. 85%; p = 0.033). Care intensity was high for patients with early and late PPC.

CONCLUSIONS:
Early PPC was associated with fewer invasive interventions within 14 days of death, yet the care intensity at EOL remained high. With early PPC, families likely receive timely psychosocial and advance care planning support without significantly altering goals of care.
Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies
Authors: Faustino E. Vincent S. , Kandil Sarah B. , Leroue Matthew K. , Sochet Anthony A. , Kong Michele , Cholette Jill M. , Nellis Marianne E. , Pinto Matthew G. , Chegondi Madhuradhar , Ramirez Michelle , Schreiber Hilary , Kerris Elizabeth W. J. , Glau Christie L. , Kolmar Amanda , Muisyo Teddy M. , Sharathkumar Anjali , Polikoff Lee , Silva Cicero T. , Ehrlich Lauren , Navarro Oscar M. , Spinella Philip C. , Raffini Leslie , Taylor Sarah N. , McPartland Tara , Shabanova Veronika ,   for the Catheter-Related Early Thromboprophylaxis with Enoxaparin (CRETE) Studies Investigators and the Pediatric Critical Care Blood Research Network (BloodNet) of the Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI)
Published: November 2024

OBJECTIVES:
In post hoc analyses of our previous phase 2b Bayesian randomized clinical trial (RCT), prophylaxis with enoxaparin reduced central venous catheter (CVC)-associated deep venous thrombosis (CADVT) in critically ill older children but not in infants. The goal of the Catheter-Related Early Thromboprophylaxis with Enoxaparin (CRETE) Studies is to investigate this newly identified age-dependent heterogeneity in the efficacy of prophylaxis with enoxaparin against CADVT in critically ill children.

DESIGN:
Two parallel, multicenter Bayesian superiority explanatory RCTs, that is, phase 3 for older children and phase 2b for infants, and an exploratory mechanistic nested case-control study (Trial Registration ClinicalTrials.gov NCT04924322, June 7, 2021).

SETTING:
At least 15 PICUs across the United States.

PATIENTS:
Older children 1–17 years old (n = 90) and infants older than 36 weeks corrected gestational age younger than 1 year old (n = 168) admitted to the PICU with an untunneled CVC inserted in the prior 24 hours. Subjects with or at high risk of clinically relevant bleeding will be excluded.

INTERVENTIONS:
Prophylactic dose of enoxaparin starting at 0.5 mg/kg then adjusted to anti-Xa range of 0.2–0.5 international units (IU)/mL for older children and therapeutic dose of enoxaparin starting at 1.5 mg/kg then adjusted to anti-Xa range of greater than 0.5–1.0 IU/mL or 0.2–0.5 IU/mL for infants while CVC is in situ.

MEASUREMENTS AND MAIN RESULTS:
Randomization is 2:1 to enoxaparin or usual care (no enoxaparin) for older children and 1:1:1 to either of 2 anti-Xa ranges of enoxaparin or usual care for infants. Ultrasonography will be performed after removal of CVC to assess for CADVT. Subjects will be monitored for bleeding. Platelet poor plasma will be analyzed for markers of thrombin generation. Samples from subjects with CADVT will be counter-matched 1:1 to subjects without CADVT from the opposite trial arm. Institutional Review Board approved the “CRETE Studies” on July 1, 2021. Enrollment is ongoing with planned completion in July 2025 for older children and July 2026 for infants.
Development of a Scoring Model to Predict Severe Dengue in Children at Admission to Emergency Care
Authors: Srinivasan Ranjini , Govardhan Chaitra , Krishna Sushma , Selvam Sumithra 
Published: November 2024

Objective
Dengue has emerged as the most widely spread mosquito-borne disease, hyperendemic in India. Although severe dengue occurs only in a small proportion of cases, delays in the recognition and management can result in significant morbidity and mortality. Risk stratification of children in the emergency care and identifying those at risk for worsening during hospital stay facilitates optimum utilization of health care resources. The objective of our study was to develop and validate a scoring model to predict the development of severe dengue in hospitalized children by identifying risk factors present in them at the time of admission to the emergency department.

Methods
A retrospective study of consecutive children aged 1 month to 18 years admitted with serologically confirmed dengue from January 2019 through December 2021 was conducted. Analysis of clinical and laboratory parameters of children resulted in the development of a comprehensive predictive scoring model. This model was internally validated prospectively on 107 children presenting with nonsevere dengue to emergency care.

Results
A total of 743 children with confirmed dengue were studied out of which 216 (29.1%) had severe dengue. Presence of third spacing (odds ratio [OR] 3.74, 95% confidence interval [CI] 1.088–7.42, P < 0.001), tender hepatomegaly (OR 1.62, 95% CI 1.04–2.52, P < 0.032), respiratory distress (OR 3.50, 95% CI 1.89–6.51, P < 0.001), and moderate (OR 3.51, 95% CI 1.82–6.74, P < 0.001) to severe (OR 4.76, 95% CI 2.59–8.76, P < 0.001) elevation of aspartate aminotransferase were independent risk factors found to be associated with development of severe dengue. A score ≥7 had a specificity of 87%, negative predictive value of 86%, and overall diagnostic accuracy of 78.5% for predicting severe dengue.

Conclusions
The dengue severity scoring model was found to have reasonable diagnostic accuracy in predicting severe disease prior to hospitalization. However, more studies are required to validate the score in different emergency care settings with varied pediatric populations.
Oral Ketamine and Midazolam for Procedural Sedation in the Pediatric Emergency Department
Authors: Del Pizzo Jeannine , Fein Joel A. 
Published: November 2024

Introduction
Needle-free procedural sedation (PS) is an attractive option for children presenting to the emergency department (ED) who require a painful procedure, as it avoids inflicting additional pain either with intravenous line placement or intramuscular injection. While use of oral (PO) ketamine has been reported in the literature, limited information is available to guide ED-based use in children.

Methods
This is a descriptive study of the patient experience receiving PS with the following regimen: PO ketamine 6 mg/kg (max of 200 mg) with or without PO midazolam 0.5 mg/kg (max 15 mg) approximately 30 minutes before a procedure. We performed a retrospective chart review of children younger than 18 years receiving this PS regimen at a tertiary care children's hospital ED and an affiliated community hospital ED from January 1 through September 30, 2023.

Results
Fifty-eight children were sedated with PO ketamine during the study period. The most common procedure performed was laceration repair (46.5%), followed by incision and drainage (17.3%). All but 2 children received PO midazolam along with PO ketamine. Eight patients received additional medications due to inadequate sedation. Sedation depth was clinician-reported as moderate in 74.1% (43), mild in 15.5% (9), and deep in 10.3% (6). Procedures were completed in 98.3% (57) cases. 93.1% (54) of patients had no adverse event (AE) of any kind and no patient had a significant adverse event (SAE).

Discussion
PO ketamine with or without midazolam resulted in procedure completion of a variety of procedures in the pediatric ED with minimal AE, no SAE, and without need for additional sedative medications in 86.2% (50). This regimen is an option for needle-free moderate PS in this setting. Further study is needed to clarify the benefit of the addition of midazolam to PO ketamine, rates of AE and SAE, sedation duration, and recovery times.
Evaluating the Effectiveness of a Mobile Health Intervention on Enhancing HIV Knowledge in Sexual and Gender Minority Men
Authors: Dos Santos Fabiana Cristina , Garofalo Robert , Kuhns Lisa M. , Scherr Thomas , Schnall Rebecca 
Published: November 2024

Background:
In the United States, young men who have sex with men (YMSM) and young transgender women (YTGW) are disproportionately affected by HIV infection. Adequate HIV knowledge is critical for protecting adolescents and young adults at risk for HIV. This study aimed to evaluate the effectiveness of the mLab App intervention in enhancing HIV knowledge among YMSM and YTGW.

Methods:
This study was a secondary analysis of data collected from a randomized controlled trial (RCT) evaluating the effect of the mLab App on HIV knowledge. We calculated interactions between groups (mLab App intervention, standard of care, at-home testing) over time (6 and 12 months) following the baseline observation, indicating a difference in the outcome scores from baseline to each time across groups.

Results:
Although the mLab App group initially had lower HIV knowledge than those in other groups, access to the App demonstrated a progressive impact on HIV knowledge over time. Despite the absence of a statistically significant effect at the 6-month follow-up, the long-term evaluation suggests improvements in HIV knowledge during the 12-month intervention follow-up.

Conclusions:
Our study suggests the potential of the mLab App as a valuable tool for long-term HIV education and awareness for YMSM and YTGW. Further research is needed to understand the factors influencing the short-term effect on HIV knowledge. The mLab App may be a useful intervention for improving HIV knowledge.
Recognition of an appropriate mating partner using cuticular hydrocarbons in a species with an extreme intra-sexual dimorphism
Authors: Moris Victoria , Wirtgen Aline , Niehuis Oliver , Schmitt Thomas 
Published: November 2024

AbstractAttracting a mate at the right time is critical for many species that reproduce sexually. In insects, short-range communication between potential mates is often mediated by cuticular hydrocarbons (CHCs), which cover most of the insect cuticle. Although the CHC profiles of many insects have been studied, we know little about what aspects of a CHC profile cause changes in mate attractiveness over the lifetime of an individual. We addressed this question by studying the mason waspOdynerus spinipes, whose females exhibit age-related quantitative changes in their CHC profile composition. First, we created an ethogram of the male mating behavior. We knew from preliminary investigations that males do not attempt to mate with recently eclosed adult females. By coating wasp dummies with different CHC extracts, we were able to show that the CHC profiles of 3-day-old females are indeed more attractive to males than those of 0-day-old females. The increased attractiveness of 3-day-old females compared to younger females was negatively correlated with the relative abundance of methyl-branched alkanes in the CHC profile of the females. These results, and the fact that the CHC profile of males is characterized by a high relative abundance of methyl-branched alkanes throughout the adult wasp lifetime, suggest that inO. spinipes, methyl-branched alkanes may act as anti-aphrodisiacs that reduce the harassment of females by males before the females are ready to mate.
Prey attracting but not repelled by predators suggests an asymmetric investment in the encounter-avoid-escape sequence
Authors: Ferry Nicolas , Fiderer Christian , Peters Anne , Ballmann Axel , Heurich Marco 
Published: November 2024

AbstractUnderstanding predator-prey interactions, particularly how species use space and time to influence encounter rates, is crucial in ecology. Camera traps, while not being able to directly measure encounters of large free-roaming species, can help estimating how species tolerate or avoid proximity with eachother. We used data from a one-year study in four German protected areas used 283 camera traps and applied recurrent event analysis to explore interactions among three prey species (red deer, roe deer, wild boar) and two predators (grey wolf, Eurasian lynx). Prey visitation rates were unaffected by predators, but wolves showed a strong attraction to prey, with visitation rates approximatively seven times higher right after prey occurrence. Insufficient data hindered robust pattern estimation regarding the Eurasian lynx. This suggests an asymmetry where predators need to succeed at every stage of the encounter sequence, while prey can disrupt the process at any stage to avoid being caught.