bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viral Shedding in Recipients of Live Attenuated Influenza Vaccine in the 2016–2017 and 2017–2018 Influenza Seasons in the United Kingdom
Authors: Jackson David , Pitcher Max , Hudson Chris , Andrews Nick , Southern Jo , Ellis Joanna , Höschler Katja , Pebody Richard , Turner Paul J , Miller Elizabeth , Zambon Maria 
Published: August 2019

Abstract

Background
The (H1N1)pdm09 live attenuated influenza vaccine (LAIV) strain was changed for the 2017–2018 influenza season to improve viral fitness, following poor protection against (H1N1)pdm09 viruses in 2015–2016. We conducted LAIV virus shedding studies to assess the effect of this change.

Methods
Children aged 2–18 years were recruited to receive LAIV in the 2016–2017 (n = 641) and 2017–2018 (n = 362) influenza seasons. Viruses from nasal swabs taken 1, 3, and 6 days postvaccination were quantified by reverse-transcription polymerase chain reaction and area under the curve titers were determined. Presence and quantity of shedding were compared between strains and seasons with adjustment for age and prior LAIV (n = 436), inactivated seasonal vaccine (n = 100), or (H1N1)pdm09 vaccine (n = 166) receipt.

Results
(H1N1)pdm09 detection (positivity) in 2016–2017 and 2017–2018 (11.2% and 3.9%, respectively) was lower than that of H3N2 (19.7% and 18.7%, respectively) and B/Victoria (28.9% and 33.9%, respectively). (H1N1)pdm09 positivity was higher in 2016–2017 than 2017–2018 (P = .005), but within shedding-positive participants, the (H1N1)pdm09 titer increased in 2017–2018 (P = .02). H3N2 and influenza B titers were similar between seasons. Positivity declined with age, and prior vaccination reduced the likelihood of shedding influenza B but not (H1N1)pdm09.

Conclusions
The (H1N1)pdm09 titer increased in 2017–2018, indicating more efficient virus replication in shedding-positive children than the 2016–2017 strain, although overall positivity was reduced. Age and vaccination history require consideration when correlating virus shedding and protection.

Clinical Trials Registration
NCT02143882, NCT02866942, and NCT03104790.
{1,2,3}-Restricted Connectivity of $(n,k)$-Enhanced Hypercubes
Authors: Yu Hui , Yang Jiejie , Lin Limei , Huang Yanze , Li Jine , Chen Riqing 
Published: August 2019

Abstract
The connectivity of a graph is a classic measure for fault tolerance of the network. Restricted connectivity measure is a crucial subject for a multiprocessor system’s ability to tolerate fault processors, and improves the connectivity measurement accuracy. Furthermore, if a network possesses a restricted connectivity property, it is more reliable with a lower vertex failure rate compared with other networks. The $\left (n,k\right )$-dimensional enhanced hypercube, denoted by $Q_{n,k}$, a variant of hypercube, which is a well-known interconnection network. In this paper, we analyze the fault tolerant properties for $\left (n,k\right )$-enhanced hypercube, and establish the $1$-restricted connectivity of $Q_{n,k} (n\ge k+1)$ and $\{2,3\}$-restricted connectivity of $(n,k)$-enhanced hypercube $Q_{n,k} (n=k+1)$. Furthermore, we propose the tight upper bound of $\{2,3\}$-restricted connectivity of $Q_{n,k} (n&gt; k+1)$. Moreover, we show many figures to better illustrate the process of the proofs.
Ovarian damage from chemotherapy and current approaches to its protection
Authors: Spears N , Lopes F , Stefansdottir A , Rossi V , De Felici M , Anderson R A , Klinger F G 
Published: August 2019

Abstract

Background
Anti-cancer therapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicle reserve is extremely sensitive to the effects of chemotherapy and radiotherapy. While oocyte, embryo and ovarian cortex cryopreservation can help some women with cancer-induced infertility achieve pregnancy, the development of effective methods to protect ovarian function during chemotherapy would be a significant advantage.

Objective and rationale
This paper critically discusses the different damaging effects of the most common chemotherapeutic compounds on the ovary, in particular, the ovarian follicles and the molecular pathways that lead to that damage. The mechanisms through which fertility-protective agents might prevent chemotherapy drug-induced follicle loss are then reviewed.

Search methods
Articles published in English were searched on PubMed up to March 2019 using the following terms: ovary, fertility preservation, chemotherapy, follicle death, adjuvant therapy, cyclophosphamide, cisplatin, doxorubicin. Inclusion and exclusion criteria were applied to the analysis of the protective agents.

Outcomes
Recent studies reveal how chemotherapeutic drugs can affect the different cellular components of the ovary, causing rapid depletion of the ovarian follicular reserve. The three most commonly used drugs, cyclophosphamide, cisplatin and doxorubicin, cause premature ovarian insufficiency by inducing death and/or accelerated activation of primordial follicles and increased atresia of growing follicles. They also cause an increase in damage to blood vessels and the stromal compartment and increment inflammation. In the past 20 years, many compounds have been investigated as potential protective agents to counteract these adverse effects. The interactions of recently described fertility-protective agents with these damage pathways are discussed.

Wider implications
Understanding the mechanisms underlying the action of chemotherapy compounds on the various components of the ovary is essential for the development of efficient and targeted pharmacological therapies that could protect and prolong female fertility. While there are increasing preclinical investigations of potential fertility preserving adjuvants, there remains a lack of approaches that are being developed and tested clinically.
The Image Size of Iterated Rational Maps over Finite Fields
Authors: Juul Jamie 
Published: August 2019

Abstract
Let $\varphi : {{\mathbb{P}}}^1( {{\mathbb{F}}}_q)\to{{\mathbb{P}}}^1( {{\mathbb{F}}}_q)$ be a rational map of degree $d&gt;1$ on a fixed finite field. We give asymptotic formulas for the size of image sets $\varphi ^n( {{\mathbb{P}}}^1( {{\mathbb{F}}}_q))$ as a function of $n$. This is done using properties of Galois groups of iterated maps, whose connection to the size of image sets is established via the Chebotarev Density Theorem. We apply our results in the following setting. For a rational map defined over a number field, consider the reduction of the map modulo each prime of the number field. We use our results to give explicit bounds on the proportion of periodic points in the residue fields.
Seshadri Constants for Curve Classes
Authors: Fulger Mihai 
Published: August 2019

AbstractWe develop a local positivity theory for movable curves on projective varieties similar to the classical Seshadri constants of nef divisors. We give analogues of the Seshadri ampleness criterion, of a characterization of the augmented base locus of a big and nef divisor, and of the interpretation of Seshadri constants as an asymptotic measure of jet separation. As application, we show in any characteristic that if $C$ is a smooth curve with ample normal bundle in a smooth projective variety then the class of $C$ is in the strict interior of the Mori cone. This was conjectured by Peternell and proved by Ottem and Lau in Characteristic 0.
Sensitivity of Human Papillomavirus (HPV) Lineage and Sublineage Variant Pseudoviruses to Neutralization by Nonavalent Vaccine Antibodies
Authors: Godi Anna , Kemp Troy J , Pinto Ligia A , Beddows Simon 
Published: August 2019

Abstract
Natural variants of human papillomavirus (HPV) are classified into lineages and sublineages based upon whole-genome sequence, but the impact of diversity on protein function is unclear. We investigated the susceptibility of 3–8 representative pseudovirus variants of HPV16, HPV18, HPV31, HPV33, HPV45, HPV52, and HPV58 to neutralization by nonavalent vaccine (Gardasil®9) sera. Many variants demonstrated significant differences in neutralization sensitivity from their consensus A/A1 variant but these were of a low magnitude. HPV52 D and HPV58 C variants exhibited >4-fold reduced sensitivities compared to their consensus A/A1 variant and should be considered distinct serotypes with respect to nonavalent vaccine-induced immunity.
Selenoprotein P as a significant regulator of pancreatic β cell function
Authors: Saito Yoshiro 
Published: August 2019

AbstractSelenoprotein P (SeP; encoded by SELENOP) is selenium (Se)-rich plasma protein that is mainly produced in the liver. SeP functions as a Se-transport protein to deliver Se from the liver to other tissues, such as the brain and testis. The protein plays a pivotal role in Se metabolism and antioxidative defense, and it has been identified as a ‘hepatokine’ that causes insulin resistance in type 2 diabetes. SeP levels are increased in type 2 diabetes patients, and excess SeP impairs insulin signalling, promoting insulin resistance. Furthermore, increased levels of SeP disturb the functioning of pancreatic β cells and inhibit insulin secretion. This review focuses on the biological function of SeP and the molecular mechanisms associated with the adverse effects of excess SeP on pancreatic β cells’ function, particularly with respect to redox reactions. Interactions between the liver and pancreas are also discussed.
Stereotactic radiotherapy using the CyberKnife is effective for local control of bone metastases from differentiated thyroid cancer
Authors: Ishigaki Takayuki , Uruno Takashi , Sugino Kiminori , Masaki Chie , Akaishi Junko , Hames Kiyomi Y , Suzuki Akifumi , Tomoda Chisato , Matsuzu Kenichi , Ohkuwa Keiko , Kitagawa Wataru , Nagahama Mitsuji , Miyazaki Shinichiro , Ito Koichi 
Published: August 2019

ABSTRACT
Differentiated thyroid cancer (DTC) is associated with a good long-term prognosis, but bone metastases can adversely affect patients’ quality of life and survival. Stereotactic radiotherapy (SRT) can deliver high-dose irradiation to target lesions and it has been reported to be useful for various cancers. However, few studies have examined the efficacy of SRT for thyroid cancer. In the present study, the aim was to investigate the efficacy of SRT using the CyberKnife for bone metastases from DTC. From September 2013 to April 2018, SRT with the CyberKnife system was used to treat 60 bone metastases from DTC in 13 patients. The patients’ medical records were retrospectively reviewed to obtain information about the adverse events associated with SRT. Of the 60 lesions, 40 could be evaluated by follow-up CT for therapeutic effectiveness, and the RECIST criteria were used to assess the response. The cancers were papillary cancer in 3 patients, follicular cancer in 9 and poorly differentiated cancer in 1. SRT was delivered in 1–10 fractions, with a median dose of 27 Gy (range, 8–48 Gy). Adverse events were infrequent and mild. The median follow-up of the 40 lesions was 11 (range, 2–56) months. The responses were partial response in 2 lesions, stable disease in 37 lesions and progressive disease in 1 lesion, with a 1-year local control rate of 97.1%. The present study showed that SRT using the CyberKnife system was a feasible and effective treatment for bone metastases of DTC.
Secular dynamics of binaries in stellar clusters – II. Dynamical evolution
Authors: Hamilton Chris , Rafikov Roman R 
Published: August 2019

AbstractDense stellar clusters are natural sites for the origin and evolution of exotic objects such as relativistic binaries (potential gravitational wave sources) and blue stragglers. We investigate the secular dynamics of a binary system driven by the global tidal field of an axisymmetric stellar cluster in which the binary orbits. In a companion paper we developed a general Hamiltonian framework describing such systems. The effective (doubly-averaged) Hamiltonian derived there encapsulates all information about the tidal potential experienced by the binary in its orbit around the cluster in a single parameter Γ. Here we provide a thorough exploration of the phase-space of the corresponding secular problem as Γ is varied. We find that for Γ > 1/5 the phase-space structure and the evolution of binary orbital elements are qualitatively similar to the Lidov–Kozai problem. However, this is only one of four possible regimes, because the dynamics are qualitatively changed by bifurcations at Γ = 1/5, 0, −1/5. We show how the dynamics are altered in each regime and calculate characteristics such as the secular evolution time-scale and maximum possible eccentricity. We verify the predictions of our doubly-averaged formalism numerically and find it to be very accurate when its underlying assumptions are fulfilled, typically meaning that the secular time-scale should exceed the period of the binary around the cluster by ≳10–102 (depending on the cluster potential and binary orbit). Our results may be relevant for understanding the nature of a variety of exotic systems harboured by stellar clusters.
Hubble Frontier Field photometric catalogues of Abell 370 and RXC J2248.7−4431: multiwavelength photometry, photometric redshifts, and stellar properties
Authors: Bradač Maruša , Huang Kuang-Han , Fontana Adriano , Castellano Marco , Merlin Emiliano , Amorín Ricardo , Hoag Austin , Strait Victoria , Santini Paola , Ryan Russell E , Casertano Stefano , Lemaux Brian C , Lubin Lori M , Schmidt Kasper B , Schrabback Tim , Treu Tommaso , von der Linden Anja , Mason Charlotte A , Wang Xin 
Published: August 2019

ABSTRACT
This paper presents multiwavelength photometric catalogues of the last two Hubble Frontier Fields (HFFs), the massive galaxy clusters Abell 370 and RXC J2248.7−4431. The photometry ranges from imaging performed on the Hubble Space Telescope to ground-based Very Large Telescope and Spitzer/Infrared Array Camera, in collaboration with the ASTRODEEP team, and using the ASTRODEEP pipeline. While the main purpose of this paper is to release the catalogues, we also perform, as a proof of concept, a brief analysis of z &gt; 6 objects selected using dropout method, as well as spectroscopically confirmed sources and multiple images in both clusters. While dropout methods yield a sample of high-z galaxies, the addition of longer wavelength data reveals that as expected the samples have substantial contamination at the ∼30–45 per cent level by dusty galaxies at lower redshifts. Furthermore, we show that spectroscopic redshifts are still required to unambiguously determine redshifts of multiply imaged systems. Finally, the now publicly available ASTRODEEP catalogues were combined for all HFFs and used to explore stellar properties of a large sample of 20 000 galaxies across a large photometric redshift range. The powerful magnification provided by the HFF clusters allows for an exploration of the properties of galaxies with intrinsic stellar masses as low as M* ≳ 107 M⊙ and intrinsic star formation rates ∼0.1–1 M⊙ yr−1 at z &gt; 6.
Can intrinsic alignments of elongated low-mass galaxies be used to map the cosmic web at high redshift?
Authors: Pandya Viraj , Primack Joel , Behroozi Peter , Dekel Avishai , Zhang Haowen , Eckholm Elliot , Faber Sandra M , Ferguson Henry C , Giavalisco Mauro , Guo Yicheng , Hathi Nimish , Kodra Dritan , Koekemoer Anton M , Koo David C , Newman Jeffrey , van der Wel Arjen 
Published: August 2019

ABSTRACT
Hubble Space Telescope observations show that low-mass ($M_*=10^9\!-\!10^{10}\, \mathrm{M}_{\odot }$) galaxies at high redshift (z = 1.0–2.5) tend to be elongated (prolate) rather than disky (oblate) or spheroidal. This is explained in zoom-in cosmological hydrodynamical simulations by the fact that these galaxies are forming in cosmic web filaments where accretion happens preferentially along the direction of elongation. We ask whether the elongated morphology of these galaxies allows them to be used as effective tracers of cosmic web filaments at high redshift via their intrinsic alignments. Using mock light cones and spectroscopically confirmed galaxy pairs from the Cosmic Assembly Near-infared Deep Extragalactic Legacy Survey (CANDELS), we test two types of alignments: (1) between the galaxy major axis and the direction to nearby galaxies of any mass and (2) between the major axes of nearby pairs of low-mass, likely prolate, galaxies. The mock light cones predict strong signals in 3D real space, 3D redshift space, and 2D projected redshift space for both types of alignments (assuming prolate galaxy orientations are the same as those of their host prolate haloes), but we do not detect significant alignment signals in CANDELS observations. However, we show that spectroscopic redshifts have been obtained for only a small fraction of highly elongated galaxies, and accounting for spectroscopic incompleteness and redshift errors significantly degrades the 2D mock signal. This may partly explain the alignment discrepancy and highlights one of several avenues for future work.
On the dust temperatures of high-redshift galaxies
Authors: Liang Lichen , Feldmann Robert , Kereš Dušan , Scoville Nick Z , Hayward Christopher C , Faucher-Giguère Claude-André , Schreiber Corentin , Ma Xiangcheng , Hopkins Philip F , Quataert Eliot 
Published: August 2019

Abstract
Dust temperature is an important property of the interstellar medium (ISM) of galaxies. It is required when converting (sub)millimetre broad-band flux to total infrared luminosity (LIR), and hence star formation rate, in high-redshift galaxies. However, different definitions of dust temperatures have been used in the literature, leading to different physical interpretations of how ISM conditions change with, e.g. redshift and star formation rate. In this paper, we analyse the dust temperatures of massive ($M_{\rm star} \gt 10^{10}\, \mathrm{M}_{\odot }$) $z$ = 2–6 galaxies with the help of high-resolution cosmological simulations from the Feedback in Realistic Environments (fire) project. At $z$ ∼ 2, our simulations successfully predict dust temperatures in good agreement with observations. We find that dust temperatures based on the peak emission wavelength increase with redshift, in line with the higher star formation activity at higher redshift, and are strongly correlated with the specific star formation rate. In contrast, the mass-weighted dust temperature, which is required to accurately estimate the total dust mass, does not strongly evolve with redshift over $z$ = 2–6 at fixed IR luminosity but is tightly correlated with LIR at fixed $z$. We also analyse an ‘equivalent’ dust temperature for converting (sub)millimetre flux density to total IR luminosity, and provide a fitting formula as a function of redshift and dust-to-metal ratio. We find that galaxies of higher equivalent (or higher peak) dust temperature (‘warmer dust’) do not necessarily have higher mass-weighted temperatures. A ‘two-phase’ picture for interstellar dust can explain the different scaling relations of the various dust temperatures.
Modelling Kepler eclipsing binaries: homogeneous inference of orbital and stellar properties
Authors: Windemuth D , Agol E , Ali A , Kiefer F 
Published: August 2019

Abstract
We report on the properties of eclipsing binaries (EBs) from the Kepler mission with a newly developed photometric modelling code, which uses the light curve, spectral energy distribution of each binary, and stellar evolution models to infer stellar masses without the need for radial velocity (RV) measurements. We present solutions and posteriors to orbital and stellar parameters for 728 systems, forming the largest homogeneous catalogue of full Kepler binary parameter estimates to date. Using comparisons to published RV measurements, we demonstrate that the inferred properties (e.g. masses) are reliable for well-detached main-sequence (MS) binaries, which make up the majority of our sample. The fidelity of our inferred parameters degrades for a subset of systems not well described by input isochrones, such as short-period binaries that have undergone interactions, or binaries with post-MS components. Additionally, we identify 35 new systems which show evidence of eclipse timing variations, perhaps from apsidal motion due to binary tides or tertiary companions. We plan to subsequently use these models to search for and constrain the presence of circumbinary planets in Kepler EB systems.
Dark matter bars in spinning haloes
Authors: Collier Angela , Shlosman Isaac , Heller Clayton 
Published: August 2019

ABSTRACT
We study non-linear response of spinning dark matter (DM) haloes to dynamic and secular evolution of stellar bars in the embedded galactic discs, using high-resolution numerical simulations. For a sequence of haloes with the cosmological spin parameter λ = 0–0.09, and a representative angular momentum distribution, we analyse evolution of induced DM bars amplitude and quantify parameters of the response as well as trapping of DM orbits and angular momentum transfer by the main and secondary resonances. We find that (1) maximal amplitude of DM bars depends strongly on λ, while that of the stellar bars is indifferent to λ; (2) efficiency of resonance trapping of DM orbits by the bar increases with λ, and so is the mass and the volume of DM bars; (3) contribution of resonance transfer of angular momentum to the DM halo increases with λ, and for larger spin, the DM halo ‘talks’ to itself, by moving the angular momentum to larger radii – this process is maintained by resonances; and (4) prograde and retrograde DM orbits play different roles in angular momentum transfer. The ‘active’ part of the halo extends well beyond the bar region, up to few times the bar length in equatorial plane and away from this plane. (5) We model evolution of discless DM haloes and haloes with frozen discs, and found them to be perfectly stable to any Fourier modes. Finally, further studies adopting a range of mass and specific angular momentum distributions of the DM halo will generalize the dependence of DM response on the halo spin and important implications for direct detection of DM and that of the associated stellar tracers, such as streamers.
Embedding planetesimals into white dwarf discs from large distances
Authors: Grishin Evgeni , Veras Dimitri 
Published: August 2019

ABSTRACT
The discovery of the intact minor planet embedded in the debris disc orbiting SDSS J1228+1040 raises questions about the dynamical history of the system. Further, the recent passage of the potentially interstellar object 1I/’Oumuamua within the Solar system has re-ignited interest in minor body flux through exoplanetary systems. Here, we utilize the new analytical formalism from Grishin et al. (2019) to estimate the rate at which the gaseous components of typical white dwarf discs trap an exo-planetesimal. We compare the types of captured orbits which arise from planetesimals originating from the interstellar medium, exo-Kuiper belts, and exo-Oort clouds. We find that the rate of interstellar medium injection is negligible, whereas capture of both exo-Kuiper and exo-Oort cloud planetesimals is viable, but strongly size-dependent. For a gaseous disc which extends much beyond its Roche limit, capture is more probable than disruption at the Roche limit. We find that the capture probability linearly increases with the radial extent of the disc. Even in systems without minor planets, capture of smaller bodies will change the disc size distribution and potentially its temporal variability. Our formalism is general enough to be applied to future discoveries of embedded planetesimals in white dwarf debris discs.