bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Outbreak of Respiratory Viral Infections in a Professional Ice Hockey Team
Authors: Grönroos Wilma , Helenius Petri , Valtonen Maarit , Waris Matti , Heinonen Olli J. , Ruuskanen Olli 
Published: October 2024

ABSTRACTBackgroundViral acute respiratory infections (ARIs) are an important cause of illness in athletes. However, their impact on ice hockey players is unclear.MethodWe describe an outbreak of ARIs in a professional ice hockey team.ResultsContrary to expected influenza, the 40‐day outbreak was caused by 8 different respiratory viruses, that is, 2 different influenza A viruses, human coronavirus‐NL63 (HCoV‐NL63), respiratory syncytial viruses (RSV) A and B, 2 different rhinoviruses, enterovirus D68, and parainfluenza type 2 virus.ConclusionOnly influenza A and HCoV‐NL63 were possibly spread within the team thus suggesting an important contraction from the community. The burden of illness was substantial.
Influence of reduction treatment for TiNb2O7 nanoparticles on the electrochemical properties for Li‐ion batteries
Authors: Ou Chang‐Ying , Som Sudipta , Gupta Karan Kumar , Yu Chun Wei , Lu Chung‐Hsin 
Published: October 2024

AbstractThe discharge capacities and rate capability of TiNb2O7 powders were enhanced through the additional postreduction treatment. X‐ray photoelectron spectroscopy and electron paramagnetic resonance results confirmed the formation of oxygen vacancies in TiNb2O7 powders after a reduction treatment. The appearance of oxygen vacancies in TiNb2O7 powders formed the impurity level in the forbidden gap and decreased the bandgap values of TiNb2O7. Compared with the pristine TiNb2O7 powders, when TiNb2O7 powders were reduced at 400°C for 40 min, the charge transfer resistance of prepared samples was reduced from 43.67 to 19.35 Ω, and the pseudocapacitive contribution of TiNb2O7 was increased from 44% to 59%. In addition, the discharge capacities at 0.1 and 20 C of prepared batteries were increased by 10.84% and 105.85%, respectively. On the other hand, increasing the temperature in the reduction treatment caused the formation of Ti4+/Ti3+ and Nb5+/Nb4+ pairs and decreased the amounts of available redox couples, thereby deteriorating the electrochemical performance of prepared batteries. The results in the present study revealed that the discharge capacities and rate capability of TiNb2O7 powders were enhanced through a postreduction treatment.
NAT10‐mediated RNA ac4C acetylation contributes to the myocardial infarction‐induced cardiac fibrosis
Authors: Li Jun , Yushanjiang Feierkaiti , Fang Zhao , Liu Wan‐li 
Published: November 2024

AbstractCardiac fibrosis is featured cardiac fibroblast activation and extracellular matrix accumulation. Ac4C acetylation is an important epigenetic regulation of RNAs that has been recently discovered, and it is solely carried out by NAT10, the exclusive enzyme used for the modification. However, the potential regulatory mechanisms of ac4C acetylation in myocardial fibrosis following myocardial infarction remain poorly understood. In our study, we activated fibroblasts in vitro using TGF‐β1 (20 ng/mL), followed by establishing a myocardial infarction mouse model to evaluate the impact of NAT10 on collagen synthesis and cardiac fibroblast proliferation. We utilized a NAT10 inhibitor, Remodelin, to attenuate the acetylation capacity of NAT10. In the cardiac fibrosis tissues of chronic myocardial infarction mice and cultured cardiac fibroblasts (CFs) in response to TGF‐β1 treatment, there was an elevation in the levels of NAT10 expression. This increase facilitated proliferation, the accumulation of collagens, as well as fibroblast‐to‐myofibroblast transition. Through the administration of Remodelin, we effectively reduced cardiac fibrosis in myocardial infarction mice by inhibiting NAT10's ability to acetylate mRNA. Inhibition of NAT10 resulted in changes in collagen‐related gene expression and ac4C acetylation levels. Mechanistically, we found that NAT10 upregulates the acetylation modification of BCL‐XL mRNA and enhances the stability of BCL‐XL mRNA, thereby upregulating its protein expression, inhibiting the activation of Caspase3 and blocking the apoptosis of CFs. Therefore, the crucial involvement of NAT10‐mediated ac4C acetylation is significant in the cardiac fibrosis progression, affording promising molecular targets for the treatment of fibrosis and relevant cardiac diseases.
The Clinical Efficacy and Safety of ErhBMP‐2/BioCaP/β‐TCP as a Novel Bone Substitute Using the Tooth‐Extraction‐Socket‐Healing Model: A Proof‐of‐Concept Randomized Controlled Trial
Authors: Wei Lingfei , Sun Yuanyuan , Yu Dedong , Pieterse Herman , Wismeijer Daniel , Liu Yuelian , Wu Yiqun 
Published: October 2024

ABSTRACTAimThis first randomized controlled trial in humans aimed to assess the efficacy and safety of low‐dosage Escherichia coli‐derived recombinant human bone morphogenetic protein 2 (ErhBMP‐2)‐incorporated biomimetic calcium phosphate coating‐functionalized β‐TCP (ErhBMP‐2/BioCaP/β‐TCP) as a novel bone substitute using the tooth‐extraction‐socket‐healing model.Materials and MethodsForty patients requiring dental implants after single‐root tooth extraction were enrolled in this study and randomly assigned into three groups: ErhBMP‐2/BioCaP/β‐TCP (N = 15), β‐TCP (N = 15) and natural healing (N = 10). New bone volume density from histomorphometric analyses was evaluated 6 weeks post‐operatively as the primary outcome, and other histomorphometric analyses, alveolar bone and soft‐tissue changes were the secondary outcomes. Safety parameters included adverse events, soft‐tissue healing, oral health impact profile, serum BMP‐2 concentrations and other laboratory tests.ResultsThe findings revealed a significant increase in new bone volume density in patients treated with ErhBMP‐2/BioCaP/β‐TCP compared to those receiving β‐TCP alone. The required bone augmentation procedures during implant placement surgery in the ErhBMP‐2/BioCaP/β‐TCP group were significantly less than in the natural healing group. There were no significant differences in safety parameters among the three groups.ConclusionThis clinical trial primarily proved the safety and efficacy of ErhBMP‐2/BioCaP/β‐TCP as a promising bone substitute.
Design and methodology of the harmonized diagnostic assessment of dementia for the longitudinal aging study in India: Wave 2
Authors: Khobragade Pranali Y. , Petrosyan Sarah , Dey Sharmistha , Dey A. B. , Lee Jinkook ,   the LASI‐DAD Authorship Team
Published: November 2024

AbstractThe rising burden of dementia calls for high‐quality data on cognitive decline and dementia onset. The second wave of the Harmonized Diagnostic Assessment for the Longitudinal Aging Study in India (LASI‐DAD) was designed to provide longitudinal assessments of cognition and dementia in India. All Wave 1 participants were recruited for a follow‐up interview, and a refresher sample was drawn from the Longitudinal Aging Study in India, a nationally representative cohort of Indians aged 45 and older. Respondents underwent a battery of cognitive tests, geriatric assessments, and venous blood collection. Their health and cognitive status were also assessed through an interview with a close family member or friend. Clinical consensus diagnosis was made based on the Clinical Dementia Rating®, and comprehensive data on risk factors of dementia were collected, including neurodegenerative biomarkers, sensory function, and environmental exposures. A total of 4635 participants were recruited between 2022 and 2024 from 22 states and union territories of India, accounting for 97.9% of the population in India. The response rate was 84.0%, and 71.5% of the participants provided venous blood specimen. LASI‐DAD provides rich new data to study cognition, dementia, and their risk factors longitudinally in a nationally representative sample of older adults in India. Longitudinal cognitive data, together with longitudinally assessed biomarker data and novel data on sensory function and environmental exposures, provide a unique opportunity to establish associations between risk factors and biologically defined cognitive aging phenotypes.
Halobacteria Formula Improvement of Skin Care—A Randomized, Double‐Blind, Placebo‐Controlled Clinical Study
Authors: Chan Leong‐Perng , Da‐Long Cheng , Tseng Ya‐Ping , Liang Chia‐Hua 
Published: November 2024

ABSTRACTBackgroundHalobacteria trueperi, an extremophilic microorganism thriving in high‐salt environments, produces extracellular polysaccharides with potential anti‐inflammatory and anti‐aging properties. However, its clinical efficacy in skin improvement remains unclear. This study focuses on H. trueperi TCI66207, isolated from the Pacific Ocean at a depth of 662 m near Hualien, and its potential to enhance skin parameters, aiming to develop a novel functional formulation for pharmaceutical and cosmetic use.AimsThis sudy aims to evaluate the clinical efficacy of H. trueperi TCI66207 on various skin parameters and its potential for developing new functional cosmetic formulations.Patients/MethodsA total of 40 subjects were recruited and randomly divided into two groups: the test group applied a serum containing H. trueperi TCI66207, while the placebo group used a basic serum. Subjects were instructed to apply the serum twice daily for 4 weeks. Skin parameters, including moisture, brightness, elasticity, pigmentation (spots and UV spots), texture, wrinkles, pores, and collagen density, were assessed before and after the 4‐week application period.ResultsAfter 4 weeks of using the H. trueperi TCI66207 serum, significant improvements were observed in all measured skin parameters compared to baseline, with notable enhancements in moisture, brightness, elasticity, texture, and collagen density, along with reductions in wrinkles, spots, and pore size.ConclusionsHalobacteria trueperi TCI66207 serum demonstrates a clear ability to improve skin conditions and delay signs of aging, making it a promising candidate for the development of new cosmetic formulations with potent anti‐aging and skin‐rejuvenating properties.
Energy‐Based Skin Rejuvenation: A Review of Mechanisms and Thermal Effects
Authors: Jia Ximeng , Feng Yongqiang 
Published: November 2024

ABSTRACTBackgroundEnergy‐based photoelectric and ultrasonic devices are essential for skin rejuvenation and resurfacing in the field of plastic surgery and dermatology. Both functionality and appearance are impacted by factors that cause skin to age, and various energy types have variable skin penetration depths and modes of transmission.AimThe objective is to advise safe and efficient antiaging treatment while precisely and sensitively controlling and assessing the extent of thermal damage to tissues caused by different kinds of energy‐based devices.MethodsA literature search was conducted on PubMed to review the mechanisms of action and thermal effects of photoelectric and ultrasonic devices in skin remodeling applications.ResultsThis paper reviews the thermal effects of energy‐based devices in skin resurfacing applications, including the tissue level and molecular biochemical level. It seeks to summarize the distribution form, depth of action, and influencing factors of thermal effects in combination with the mechanisms of action of various types of devices.ConclusionAccurate control of thermal damage is crucial for safe and effective skin remodeling treatments. Thorough investigation of molecular biochemical indicators and signaling pathways is needed for real‐time monitoring and prevention of severe thermal injury. Ongoing research and technological advancements will improve the accuracy and control of thermal damage during treatments.
Association among raised intraventricular pressure, clinical signs, and magnetic resonance imaging findings in dogs with congenital internal hydrocephalus
Authors: Farke Daniela , Olszewska Agnieszka , Büttner Kathrin , Schmidt Martin J. 
Published: November 2024

AbstractBackgroundDogs with internal hydrocephalus do not necessarily have high intraventricular pressure (IVP).Hypothesis/ObjectivesNot all reported MRI findings indicate high IVP and some clinical signs might be associated with elevated IVP and syringomyelia.AnimalsFifty‐three dogs.Materials and MethodsCross‐sectional study. Clinical signs and MRI findings were evaluated for an association of IVP >12 mm Hg and syringomyelia.ResultsHigh IVP was associated with obtundation OR 4.64 (95% CI 1.27‐16.93) (P = .02), head tilt OR 6.42 (95% CI 1.08‐37.97) (P = .04) and nystagmus OR 8.24 (95% CI 1.44‐47.07) (P = .02). Pain was associated with syringomyelia OR 3.4 (95% CI 0.98‐11.78) (P = .05). The number of affected ventricles was associated with high IVP OR 2.85 (95% CI 0.97‐8.33) (P = .05) and syringomyelia OR 12.74 (95% CI 2.93‐55.4) (P = .0007). Periventricular edema OR 24.46 (95% CI 4.54‐131.77), OR 7.61 (95% CI 1.91‐30.32) (P < .0002, P = .004) and signal void sign OR 17.34 (95% CI 4.01‐74.95), OR 4.18 (95% CI 1.16‐15.02) (P < .0001, P = .03) were associated with high IVP and syringomyelia. The probability for syringomyelia is lower with disruption of the internal capsule OR 0.19 (95% CI 0.05‐0.72) (P = .01) and higher VBR OR 0.25 (95% CI 0.1‐0.63) (P = .004).Conclusions and Clinical ImportancePreviously reported MRI findings are not predictive of high IVP. Clinical signs and MRI findings should be used to make a diagnosis of internal hydrocephalus in dogs with or without high IVP.
Clinical findings, prognostic factors, and outcome of protein‐losing nephropathy in cats: A retrospective study
Authors: Sugar Noam , Chen Hilla , Segev Gilad 
Published: November 2024

AbstractBackgroundPrimary glomerular disease resulting in protein‐losing nephropathy (PLN) is an uncommon cause of chronic kidney disease in cats, yet is important to recognize because it warrants specific treatment that impacts outcome.Hypothesis/ObjectiveCharacterize clinicopathologic findings, prognostic indicators, and short‐ (≤30 days) and long‐term survival of cats with PLN.AnimalsThirty‐seven cats with naturally occurring PLN.MethodsMedical records of cats with PLN admitted to a veterinary teaching hospital were retrospectively reviewed.ResultsMedian age was 3 years (range, 1.5‐11.5 years) and 17/37 (46%) were males. Short‐term survival was 57%. The estimated median survival time of all cats was 424 days (95% confidence interval [CI], 0‐1098 days). Common clinical signs included lethargy (57%), edema (46%) and weight loss (35%). Edema was more common in short‐term survivors compared with nonsurvivors (odds ratio [OR], 0.21; 95% CI, 0.05‐0.86‐20.4; P = .04). Serum creatinine concentration at presentation was negatively associated with long‐term survival (OR, 1.3; 95% CI, 1.03‐1.52; P = .01). Administration of immunosuppressive and antiproteinuric medications was more common among short‐term survivors compared with nonsurvivors (18/20 [90%] vs 9/16 [56%]; OR, 7.0; 95% CI, 1.2‐40.8; P = .05 and 17/20 [85%] vs 7/16 [44%]; OR, 7.3; 95% CI, 1.5‐35.2; P = .01, respectively). Partial or complete remission was documented in 11/31 (36%) cats and was associated with both short (OR, 3.3; 95% CI, 1.7‐6.5; P < .001) and long‐term survival (P = .003).Conclusion and Clinical ImportanceCats with PLN have a guarded prognosis, but achieving remission improves outcome. Cats presented with edema rather than azotemia are more likely to respond to treatment.
Empowering Global Health Systems to Protect, Promote and Support Optimal Breastfeeding
Authors: Zhu David T. , Gupta Tarini , Pérez‐Escamilla Rafael 
Published: November 2024

ABSTRACTBreastfeeding is a critical public health strategy for optimal child development and maternal health across the life course. The 2021 Global Burden of Diseases, Injuries and Risk Factors Study reveals that, despite reductions in mortality and disability‐adjusted life years (DALYs) attributed to suboptimal breastfeeding practices—namely, non‐exclusive breastfeeding during the first 6 months or early discontinuation within the first 2 years—low‐ and middle‐income countries (LMICs) continue to bear a staggering 50‐fold higher burden compared to high‐income nations. This inequity signals a pressing global health priority. Hence, we propose to address these challenges by first, expanding the Baby‐Friendly Hospital Initiative (BFHI) reach through community‐driven efforts such as the Baby‐Friendly Community Initiative (BFCI) to enhance breastfeeding support in both clinical and community settings; second, embedding breastfeeding counselling within national health and social protection programmes to fill in gaps in culturally competent care, drawing on large scale breastfeeding peer counselling programme experiences like the one being implemented by the US Supplemental Nutrition Program for Women, Infants and Children (WIC); third, improving maternity leave policies and workplace accommodations for breastfeeding women and fourth, stringent regulation of exploitative commercial milk formula (CMF) marketing to combat misinformation and reduce health inequities. Governments must implement strong, evidence‐driven policies—such as strict monitoring and regulation of product labelling and digital media marketing—to establish safeguards against the powerful influence of the CMF industry. Collectively, these strategies will enhance breastfeeding outcomes, reduce health disparities and drive progress across countries towards meeting the UN Sustainable Development Goals.
Combining transfer learning and statistical measures to predict performance of composite materials with limited data
Authors: Li Xue , Zhu Zhongfeng , Zhou Yingwu , Zhou Zhihao , Zhang Liwen , Chen Cheng 
Published: November 2024

AbstractPredicting the performance of composite materials is crucial for their application in civil infrastructure, yet limited experimental data often hinder the development of accurate and generalizable models. This study introduces a deep neural network (DNN) approach that combines summarizing statistics (SS) and transfer learning (TL)—termed the SSTL‐DNN approach—to address data scarcity in modeling composite materials. The computational novelty lies in the SS method's ability to extract comprehensive information from limited datasets by converting complex constitutive laws into concise statistical representations, thereby enabling efficient and effective model training. Simultaneously, the TL method enhances computational efficiency by leveraging knowledge from related tasks with abundant data to improve learning in the target task with scarce data. This combination not only reduces dependency on large datasets but also significantly improves model generalization. The proposed SSTL‐DNN approach is validated through two case studies: fiber‐reinforced polymer confined concrete and engineered cementitious composites. In both case studies, the SSTL‐DNN model reduces the required dataset size by up to 75% and decreases the validation error by 39%, compared to traditional deep learning models. These results demonstrate that the SSTL‐DNN approach not only overcomes data scarcity but also provides accurate predictions and generalization to unseen data, offering a practical solution for modeling composite materials with limited data.
Esophageal chest pain resembles heartburn in reflux metrics and response to proton pump inhibitor therapy
Authors: Ribolsi Mentore , Marchetti Lorenzo , Olmi Lucrezia Maria , Cicala Michele , Savarino Edoardo 
Published: November 2024

AbstractBackgroundGastro‐esophageal reflux disease (GERD) is the most common cause for noncardiac chest pain (NCCP), with an estimated prevalence rate ranging between 30% and 60%. Heartburn and NCCP may share common mechanisms.Aims/MethodsTo assess whether particular patterns of impedance‐pH variables characterize patients with dominant heartburn, regurgitation, or NCCP and their ability to predict proton pump inhibitor (PPI) response for each symptom, GERD patients, evaluated with high‐resolution manometry (HRM) and impedance‐pH, were included.ResultsIn total, 109 NCCP, 68 heartburn, and 64 regurgitation patients were included. Pathological reflux episodes were observed in 28%, 19%, and 56% (p < 0.001). Pathological mean nocturnal baseline impedance (MNBI) values were observed in 55%, 53%, and 34% (p < 0.05). Hypomotility was more frequent in NCCP compared to heartburn patients (p < 0.05). When comparing NCCP with heartburn, hypomotility was associated with NCCP perception (OR: 2.34, 95% CI: 1.23–4.43; p < 0.01). When comparing NCCP with regurgitation, >80 refluxes and type 2/3 esophagogastric junction (EGJ) were associated with regurgitation perception (OR: 0.31, 95% CI: 0.16–0.59; p < 0.001, and OR: 0.5, 95% CI: 0.27–0.93; p < 0.05), while pathological MNBI was associated with NCCP perception (OR: 2.34, 95% CI: 1.23–4.43; p < 0.01). 45.5% NCCP patients, 45.6% with heartburn, and 36% with regurgitation responded to PPIs (p < 0.05). At multivariate analysis, pathological MNBI or PSPW index were associated with PPI responsiveness in patients with NCCP or heartburn, while in patients with regurgitation, pathological MNBI was associated with PPI responsiveness and a reflux number >80 to PPI refractoriness.ConclusionsWe highlight the usefulness of an accurate clinical and functional evaluation of GERD patients, allowing to discriminate particular characteristics in patients with dominant heartburn, NCCP, or regurgitation, which may benefit of distinct therapeutic strategies.
Barriers and enablers to effective weight management for people living with overweight and obesity: A rapid scoping review
Authors: Mekonnen Alemayehu , Vasilevski Vidanka , Chapman Anna , Naughton Shaan , Yuen Eva , Willcox Jane , Holmes‐Truscott Elizabeth , Ananthapavan Jaithri , Tesfay Fisaha , Sweet Linda , Peeters Anna 
Published: November 2024

SummaryA scoping review was conducted to identify barriers and enablers to effective weight management in healthcare settings for people living with overweight and obesity in English‐speaking high‐income countries. Peer‐reviewed and gray literature were systematically searched in June 2024. Data were analyzed using inductive thematic analysis. Of the 15,684 unique articles identified and screened for relevance, 216 studies were included. Healthcare‐related barriers and enablers to weight management were organized under three themes: a) healthcare provider‐related factors, b) provision of care, and c) policy/funding. Prominent barriers included healthcare provider knowledge deficits and low prioritization of obesity management, mainly in the primary care setting. Weight management beyond the primary care setting was found to be especially challenging, with poor referral pathways, service fragmentation, lack of multidisciplinary practice, and restricted eligibility criteria, hindering the accessibility of services. Developing consistent policies and guidelines, improving the education of healthcare providers, and increasing funding to provide low‐cost comprehensive care, were identified as enablers to access and uptake of weight management services. Considerable overlap in the identified barriers existed across healthcare providers and settings. A whole health system approach to minimize barriers and strengthen enablers to weight management services is needed, to address rising obesity rates.