bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness and Safety of Ultrasonic Bone Scalpel Versus Conventional Method in Cervical Laminectomy: A Retrospective Study of 311 Patients
Authors: Dave Bharat R. , Krishnan Ajay , Rai Ravi Ranjan , Degulmadi Devanand , Mayi Shivanand , Gudhe Mahendra 
Published: September 2019

Study Design: Retrospective cohort study. Objectives: The aim of this study was to compare the results of cervical laminectomy (CL) performed with ultrasonic bone scalpel (UBS) or conventional method (CM). Method: This study comprised 311 CL performed by a single surgeon between January 2004 and December 2017. Group A (GpA) comprised 124 cases of CL performed using UBS, while Group B (GpB) comprised 187 cases of CL performed using CM. These 2 groups were compared in terms of demographic characteristics of patients, duration of surgery, estimated blood loss, and surgical complications. Results: GpA included 112 males and 12 females, mean age being 61.18 years. GpB comprised 166 males and 21 females, mean age being 62.04 years. Mean duration of surgery, estimated blood loss, and length of hospital stay was 65.52/70.87 minutes, 90.24/98.40 mL, and 4.80/4.87 days in GpA and GpB, respectively. Six patients were reported to have dural injuries in each group. In GpA, 2 cases of C5 palsy and 1 nerve root injury was observed, while in GpB, 3 cases of C5 palsy and no nerve root injury was reported. One patient had developed transient neurological deterioration postsurgery in GpA as against 11 patients in GpB. Conclusion: Neurological complications observed in CM leads to intensive care unit admission, additional morbidity, and additional expenditure, whereas UBS provides a safe, rapid, and effective means of performing CL, thereby decreasing the rate of surgical complications and postoperative morbidity.
Timing of Surgery in Thoracolumbar Spine Injury: Impact on Neurological Outcome
Authors: Qadir Irfan , Riew K. Daniel , Alam Syed Roman , Akram Rizwan , Waqas Muhammad , Aziz Amer 
Published: September 2019

Study Design: Retrospective cohort study. Objective: We aimed to evaluate the improvement in neurological deficit following early versus late decompression and stabilization of thoracolumbar junctional fractures. Methods: This is a retrospective evaluation of all patients with a traumatic spinal cord injury (SCI) from T11 to L2 treated at a teaching hospital between 2010 and 2017. Grouped analysis was performed comparing the cohort of patients who received early surgery within 24 hours (group 1) with those operated within 24 to 72 hours (group 2) and more than 72 hours after SCI (group 3). The primary outcome was the change in ASIA (American Spinal Injury Association) motor score at 12-month follow-up. Results: There were 317 patients (225 males and 92 females with mean age of 31.55 ± 12.43 years). A total of 144, 77, and 96 patients belonged to groups 1, 2, and 3 respectively. Improvement of at least 1 grade on ASIA classification was observed in 80, 45, and 33 patients in groups 1, 2, and 3 respectively ( P = .001). Overall, 32, 12, and 10 patients improved ≥2 grades on ASIA classification in groups 1, 2, and 3, respectively ( P = .069). On logistic regression analysis, early surgery and severity of initial injury (complete [ASIA A] vs incomplete SCI [ASIA B-D]) were found to significantly influence the potential for neurologic improvement ( P = .004 and P < .0001, respectively). Conclusion: We believe that the earlier the decompression, the better. The 72-hour cutoff represents the most promising time window during which surgical decompression has the potential to confer a neuroprotective effect in the setting of incomplete SCI (ASIA B-D) in the distal region of the spinal cord (conus medullaris).
Risk of Recurrent Instability After Arthroscopic Stabilization for Shoulder Instability in Adolescent Patients
Authors: Kramer Jonathan , Gajudo Gio , Pandya Nirav K. 
Published: September 2019

Background: With the rise of adolescent sports participation, there has been a concomitant increase in not only the incidence but also the treatment of traumatic shoulder instability. Yet, there have been limited data on the failure rates of arthroscopic shoulder stabilization in this population as well as the potential risk factors. Purpose/Hypothesis: The purpose of this study was to determine the failure rates of adolescent patients who underwent arthroscopic labral reconstruction for traumatic anterior shoulder instability. We hypothesized that adolescent failure rates would be significantly higher than what has been reported in the adult population with regard to recurrent instability after surgical intervention. Study Design: Case series; Level of evidence, 4. Methods: This was a retrospective cohort study performed at a single center. Inclusion criteria consisted of all adolescent-aged patients identified who (1) had traumatic anterior shoulder instability, (2) had radiographic findings consistent with anteroinferior capsulolabral injury, and (3) underwent arthroscopic shoulder stabilization. Patient demographics, clinical presentation, imaging, intraoperative findings, and postoperative outcomes were analyzed. Results: A total of 36 patients were identified, with a mean ± SD follow-up of 35.6 ± 13.8 months. The mean patient age at the time of the index procedure was 16.03 ± 1.67 years. All patients underwent arthroscopic shoulder stabilization consisting of arthroscopic Bankart repair. Twelve patients (33.3%) reported either recurrent instability or apprehension, of whom 9 (25.0%) developed recurrent dislocation/subluxation at a mean of 20.67 months postoperatively (range, 16-51 months). No single sport was associated with a statistically significant increased risk of redislocation, although a trend was seen toward those with postoperative participation in high-risk sporting activity. Patients who redislocated their shoulders had a higher frequency of a Hill-Sachs lesion on magnetic resonance imaging (89%) compared with those who did not (52%, P = .048). History of multiple preoperative dislocations, presence of bony Bankart pathology, off-track lesions, and number of anchors utilized were not associated with postoperative dislocation/subluxation. Conclusion: This study demonstrates that adolescent patients treated with arthroscopic shoulder stabilization have a high rate of recurrent instability. The adolescent population may benefit from other stabilization strategies and/or activity modification. Further studies are necessary to determine the reasons for the high rate of redislocation and to develop strategies for prevention.
Transphyseal Anterior Cruciate Ligament Reconstruction in the Skeletally Immature: Quadriceps Tendon Autograft Versus Hamstring Tendon Autograft
Authors: Pennock Andrew T. , Johnson Kristina P. , Turk Robby D. , Bastrom Tracey P. , Chambers Henry G. , Boutelle Kelly E. , Edmonds Eric W. 
Published: September 2019

Background: It is unclear what the optimal graft choice is for performing anterior cruciate ligament (ACL) reconstruction in a skeletally immature patient. Purpose: To evaluate outcomes and complications of skeletally immature patients undergoing transphyseal ACL reconstruction with a hamstring tendon autograft versus a quadriceps tendon autograft. Study Design: Cohort study; Level of evidence, 3. Methods: Between 2012 and 2016, 90 skeletally immature patients from a single institution underwent primary transphyseal ACL reconstruction with either a quadriceps tendon autograft or a hamstring tendon autograft based on surgeon preference (n = 3). Patient demographic, injury, radiographic, and surgical variables were documented. Outcome measures included the Lysholm score, Single Assessment Numeric Evaluation (SANE), Tegner activity score, pain, satisfaction, and complications such as graft tears and physeal abnormalities. Results: A total of 83 patients (56 hamstring tendon, 27 quadriceps tendon) were available for a minimum follow-up of 2 years or sustained graft failure. The mean age of the patients was 14.8 ± 1.4 years at the time of ACL reconstruction. No differences in chronological age, bone age, sex, patient size, or mechanism of injury were noted between groups. There were no differences in surgical variables, except that the quadriceps tendon grafts were larger than the hamstring tendon grafts (9.6 ± 0.6 mm vs 7.8 ± 0.7 mm, respectively; P < .001). Patient outcomes at a mean follow-up of 2.8 ± 0.9 years revealed no differences based on graft type, with mean Lysholm, SANE, pain, satisfaction, and Tegner scores of 96, 93, 0.6, 9.6, and 6.6, respectively, for the quadriceps tendon group and 94, 89, 0.9, 9.2, and 7.1, respectively, for the hamstring tendon group. While there were no physeal complications in either group, patients undergoing ACL reconstruction with a hamstring tendon autograft were more likely to tear their graft (21% vs 4%, respectively; P = .037). Conclusion: Skeletally immature patients undergoing ACL reconstruction can be successfully managed with either a quadriceps tendon autograft or a hamstring tendon autograft with good short-term outcomes, high rates of return to sport, and low rates of physeal abnormalities. The primary differences between grafts were that the quadriceps tendon grafts were larger and were associated with a lower retear rate. ACL reconstruction performed with a quadriceps tendon autograft may reduce early graft failure in skeletally immature patients.
Individual-, Household-, and Community-Level Determinants of Childhood Undernutrition in Bangladesh
Authors: Khanam Moriam , Shimul Shafiun N. , Sarker Abdur Razzaque 
Published: September 2019

Introduction: Childhood undernutrition is a crucial public health problem globally. The objective of this study is to measure the prevalence of childhood undernutrition and assess the distinct role of various factors on childhood undernutrition in Bangladesh. Methods: This study utilized the latest cross-sectional data from Bangladesh Demographic and Health Survey 2014. A total of 7256 data on children younger than 5 years old were analyzed. The undernutrition status of children was assessed by stunting (height-for-age), wasting (weight-for-height), and underweight (weight-for-age), while bivariate and multivariate analyses were performed to identify various individual-, household-, and community-level factors of childhood undernutrition. Results: The prevalence of stunting, wasting, and underweight were 36.5%, 14.6%, and 32.5%, respectively. Along with various individual- and household-level factors (eg, age, recent diarrheal disease, fever, number of under-5 children in the household, mother’s education and nutritional status, and wealth status), community index, particularly regional and geographic variation of community, had significant role for childhood undernutrition in Bangladesh. Conclusion: Childhood undernutrition is an overwhelming public health issue in Bangladesh. In order to improve the nutritional status of under-5 children, interventions should take into account the various predictors discussed in this study. Indeed, a joint effort by the government, nongovernmental organizations, and the community is necessary to improve the childhood nutritional status in Bangladesh.
The Chopart Variant Dislocation: Plantar Dislocation of the Cuboid and Navicular
Authors: Honeycutt M. Wesley , Perry Mark D. 
Published: September 2019

This case report demonstrates a unique variant of a Chopart dislocation resulting in a plantar cuboid and navicular dislocation without concomitant fracture in a 48-year-old man. The mechanism of injury involved a low-energy plantarflexion moment from stepping off a small embankment. This report reviews the pertinent midfoot anatomy, discusses the proposed mechanism of injury, and demonstrates an effective method of treating these complex injuries with open reduction and internal fixation. Final results with 20 months of follow-up were excellent. This unusual midfoot dislocation is a complex injury that required open treatment for anatomic restoration. In complex Chopart dislocations, early open reduction should be strongly considered as the initial treatment to properly restore anatomy and function. Level of Evidence: Level V, expert opinion.
Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience
Authors: Zarei Maryam , Shasaeefar Alireza , Kazemi Kurosh , Dehghani Masoud , Malekhosseini Seyed-Ali , Geramizadeh Bita 
Published: September 2019

Background: Intrahepatic cholangiocarcinoma is a highly malignant tumor with a very short 5-year survival. Multistep carcinogenesis has been suggested as the main pathway for the development of this tumor. Main suggested precursors have been (1) biliary intraepithelial neoplasia (BilIN) and (2) intraductal papillary neoplasm of bile duct (IPNB). The former is flat and does not produce grossly and radiologically detectable mass lesion, but the latter produces grossly identifiable lesion. Objectives: The development of bile duct dysplasia (BilIN) in chronic biliary diseases has been investigated and proved, but the incidence of BilIN in non-biliary causes of cirrhosis such as hepatitis B and non-alcoholic steatohepatitis has very rarely been investigated. In this study, we have tried to find out the prevalence of BilIN in non-biliary cirrhosis. Patients and Methods: During the study period (2017-2018) in 100 explanted livers with the diagnosis of non-biliary cirrhosis, thorough sampling (at least 20 sections) was performed, and pathologic sections were studied for the presence of BilIN. Results: In the 100 studied livers with different diagnoses of non-biliary causes of cirrhosis, 31% of cases showed BilIN-1 and 2% of cases showed BiliIN-2. No case of BilIN-3 has been identified. Discussion and Conclusions: Non-biliary causes of cirrhosis should be considered as precursors of cholangiocarcinoma (BilIN); however, the incidence of this occurrence is low.
IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia
Authors: González-García Sara , Mosquera Marta , Fuentes Patricia , Palumbo Tiziana , Escudero Adela , Pérez-Martínez Antonio , Ramírez Manuel , Corcoran Anne E. , Toribio Maria L. 
Published: September 2019

Key Points
IL-7R expression is a functional biomarker of T-ALL cells with leukemia-initiating potential and plays a crucial role in T-ALL pathogenesis. Targeting IL-7R–mediated signaling hampers leukemia-initiating activity and progression of human T-ALL.
Steady-state and regenerative hematopoiesis occurs normally in mice in the absence of GDF11
Authors: Goldstein Jill M. , Sengul Hilal , Messemer Kathleen A. , Fernández-Alfara Marcos , Garbern Jessica C. , Kristl Amy C. , Lee Richard T. , Wagers Amy J. 
Published: September 2019

Key Points
Genetic deletion of Gdf11 does not affect red blood cell formation during homeostasis or after transplant. Hematopoietic stem cell function is preserved in mice lacking Gdf11 expression within the blood lineage.
Breath analysis in gastrointestinal graft-versus-host disease after allogeneic hematopoietic cell transplantation
Authors: Hamilton Betty K. , Rybicki Lisa A. , Grove David , Ferraro Christina , Starn Jamie , Hodgeman Brittany , Elberson Jamie , Winslow Victoria , Corrigan Donna , Gerds Aaron T. , Hanna Rabi , Kalaycio Matt E. , Sobecks Ronald M. , Majhail Navneet S. , Dweik Raed A. 
Published: September 2019

Key Points
Breath analysis is a feasible novel method to detect and potentially monitor graft-versus-host disease.
Retraction Note to: Integrated physiological and proteomic analysis of embryo and endosperm reveals central salt stress response proteins during seed germination of winter wheat cultivar Zhengmai 366
Authors: Liu Dongmiao , Han Caixia , Deng Xiong , Liu Yue , Liu Nannan , Yan Yueming 
Published: September 2019

The editor has retracted this article [1] because parts of Figs. 1 and 4 were duplicated from a previously published paper by the same authors [2] without appropriate disclosure. None of the authors have responded to any correspondence from the editor about publication of this retraction notice.
Identification and optimization of PrsA in Bacillus subtilis for improved yield of amylase
Authors: Quesada-Ganuza Ane , Antelo-Varela Minia , Mouritzen Jeppe C. , Bartel Jürgen , Becher Dörte , Gjermansen Morten , Hallin Peter F. , Appel Karen F. , Kilstrup Mogens , Rasmussen Michael D. , Nielsen Allan K. 
Published: September 2019

Abstract

Background
PrsA is an extracytoplasmic folding catalyst essential in Bacillus subtilis. Overexpression of the native PrsA from B. subtilis has repeatedly lead to increased amylase yields. Nevertheless, little is known about how the overexpression of heterologous PrsAs can affect amylase secretion.

Results
In this study, the final yield of five extracellular alpha-amylases was increased by heterologous PrsA co-expression up to 2.5 fold. The effect of the overexpression of heterologous PrsAs on alpha-amylase secretion is specific to the co-expressed alpha-amylase. Co-expression of a heterologous PrsA can significantly reduce the secretion stress response. Engineering of the B. licheniformis PrsA lead to a further increase in amylase secretion and reduced secretion stress.

Conclusions
In this work we show how heterologous PrsA overexpression can give a better result on heterologous amylase secretion than the native PrsA, and that PrsA homologs show a variety of specificity towards different alpha-amylases. We also demonstrate that on top of increasing amylase yield, a good PrsA–amylase pairing can lower the secretion stress response of B. subtilis. Finally, we present a new recombinant PrsA variant with increased performance in both supporting amylase secretion and lowering secretion stress.
Genetic underpinnings of recovery after stroke: an opportunity for gene discovery, risk stratification, and precision medicine
Authors: Acosta Julián N. , Brown Stacy C. , Falcone Guido J. 
Published: September 2019

Abstract
As the number of stroke survivors continues to increase, identification of therapeutic targets for stroke recovery has become a priority in stroke genomics research. The introduction of high-throughput genotyping technologies and novel analytical tools has significantly advanced our understanding of the genetic underpinnings of stroke recovery.
Spores of Beauveria bassiana and Trichoderma lignorum as a bioinsecticide for the control of Atta cephalotes
Authors: Daza Fabian Felipe Fernandez , Roman Ginna Rodriguez , Rodriguez Marino Valencia , Vargas Ivan Andres Gonzalez , Heano Heiber Cardenas , Cereda Marney Pascoli , Mulet Raul Alberto Cuervo 
Published: September 2019

Abstract

Background
The leafcutter ant (Atta cephalotes) is associated with losses in the agricultural sector, due to its defoliating activity; for its control, biological, mechanical and chemical methods have been developed, the latter associated with adverse effects on human and environmental health. This research validated in the field for the control of the leafcutter ant (A. cephalotes) using a mixture of Beauveria bassiana and Trichoderma lignorum spores.

Methods
The effectiveness from the combination of spores of B. bassiana and T. lignorum with an initial concentration of 2 × 109 spores/ml, in the following proportions of B. bassiana and T. lignorum, A (1:1), of each fungus. It was evaluated within the university campus, comparing it with two commercial formulations, Mycotrol (B. bassiana) and Mycobac (T. lignorum). Additionally, this formulation was evaluated in 49 nests distributed 16 in 14 locations in Colombia. The formulation application was carried out by direct application, using a pump at a speed of 10 ml/m2. The effectiveness was estimated from the reduction of the flow of ants, evaluating the statistically significant differences using the ANOVA and Tukey-test.

Results
Effective control of 90% of the nests was observed in the field phase in 60 days, except in nests with areas > 50 m2 that were located in regions with high rainfall (annual average precipitation above 7000 mm), such as Buenaventura.

Conclusions
In this work, it was demonstrated that the combination of B. bassiana and T. lignorum spores represent a viable alternative for the control of the leafcutter ant, in which the effectiveness is related to several factors, including the size of the nest and the rainfall in the area.
Assessing the influence of harvesting intensities on structural diversity of forests in south-west Germany
Authors: Storch Felix , Kändler Gerald , Bauhus Jürgen 
Published: September 2019

Abstract

Background
To increase ecosystem resilience and biodiversity, the maintenance and improvement of structural and compositional diversity of forests has become an important goal in forest management for many forest owners and jurisdictions. At the same time, future harvesting intensity (HI) may increase to meet the demand for woody biomass by an increasing bioeconomy sector. Yet, the influence of HI on forest structural diversity is largely unknown. Here, we address this issue by analyzing the relationship between HI and structural diversity based on large-scale national forest inventory (NFI) data, where the latter is quantified using a previously developed Forest Structure Index and HI is expressed as wood volume removal during the period 2002–2012 for the same inventory plots.

Results
Our results show a surprisingly small impact of harvesting intensity on changes in structural diversity for most of the analysed types of forests. Only intense harvesting (> 80%–90% of initial growing stock) led to a significant reduction in structural diversity. At low to moderate HI most aspects of structural diversity were positively influenced. Only the quadratic mean DBH and the volume of large trees (≥ 40 cm DBH) were substantially negatively influenced at HI > 60% and 70% of initial growing stock, respectively.

Conclusions
In several forest types, HI could be increased without a reduction in overall structural diversity. Hence, structural diversity in these selectively managed forests appears to be a very resistant forest property in relation to HI. Other indicators at stand and landscape scale may be needed to adjust levels of HI that are suited to maintain forest biodiversity.