bluuebunny/crossref_metadata_2025_split huggingface dataset:
BgTEP: an antiprotease involved in innate immune sensing in Biomphalaria glabrata
Authors: Portet Anaïs , Galinier Richard , Pinaud Silvain , Portela Julien , Nowacki Fanny , Gourbal Benjamin , Duval David 
Published: April 2018

AbstractInsect Thioester-containing protein (iTEP) is the most recently defined group among the TEP superfamily. TEPs are key components of the immune system, and iTEPs from flies and mosquitoes were shown to be major immune weapons. Initially characterised from insects, TEP genes homologous to iTEP were further described from several other invertebrates including arthropods, cniderians and mollusks albeit with few functional characterisations. In the freshwater snail Biomphalaria glabrata, a vector of the schistosomiasis disease, the presence of a TEP protein (BgTEP) was previously described in a well-defined immune complex involving snail lectins (FREP) and schistosome parasite mucins (SmPoMuc).To investigate the potential role of BgTEP in the immune response of the snail, we first characterised its genomic organisation and its predicted protein structure. A phylogenetic analysis clustered BgTEP in a well-conserved subgroup of mollusk TEP. We then investigated the BgTEP expression profile in different snail tissues, and followed immune challenges using different kinds of intruders during infection kinetics. Results revealed that BgTEP is particularly expressed in hemocytes, the immune-specialised cells in invertebrates, and is secreted into the hemolymph. Transcriptomic results further evidenced an intruder-dependent differential expression pattern of BgTEP whilst interactome experiments showed that BgTEP is capable of binding to the surface of different microbes and parasite either in its full length form or in processed forms.Through this work, we report the first characterisation of a snail TEP. Our study also reveals that BgTEP may display an unexpected functional dual-role. In addition to its previously characterised anti-protease activity, we demonstrate that BgTEP can bind to the intruder surface membrane, which supports a likely opsonin role.
Study of melanin localization in the mature maleCalopteryx haemorrhoidalisdamselfly wings
Authors: Truong Vi Khanh , Vongsvivut Jitraporn , Geeganagamage Nipuni Mahanamanam , Tobin Mark J. , Luque Pere , Baulin Vladimir , Werner Marco , Maclaughlin Shane , Crawford Russell J. , Ivanova Elena P. 
Published: April 2018

DamselfliesCalopteryx haemorrhoidalisexhibiting black wings are found in the western Mediterranean, Algeria, France, Italy, Spain and Monaco. Wing pigmentation is caused by the presence of melanin, which is involved in physiological processes including defence reactions, wound healing and sclerotization of the insect. Despite the important physiological roles of melanin, the presence and colour variation among males and females of theC. haemorrhoidalisspecies and the localization of the pigment within the wing membrane remain poorly understood. In this study, infrared (IR) microspectroscopy, coupled with the highly collimated synchrotron IR beam, was employed in order to identify the distribution of the pigments in the wings at a high spatial resolution. It was found that the melanin is localized in the procuticle of theC. haemorrhoidalisdamselfly wings, distributed homogeneously within this layer, and not associated with the lipids of the epicuticle.
Shortening lead-time from project initiation to delivery
Authors: Økland Andreas , Johansen Agnar , Olsson Nils O.E. 
Published: April 2018

Purpose
Standardizing the development, planning and construction of public building projects can contribute to timely and efficient project delivery. This is especially relevant when there are urgent needs for capacity. The purpose of this paper is to share the experiences from the development of standardized concepts for school extensions and prison building in Norway.

Design/methodology/approach
The research questions posed in this paper are on the interaction between public entities project delivery models and standardizing building types and the construction method. To investigate the research questions, the paper presents the findings from two case studies: school and prison development and construction projects. It is based on a literature review, semi-structured interviews, document studies and quantitative data on time and cost for the planning and construction phases.

Findings
Standardization and use of modularized building systems can contribute to shortened delivery time by reducing the duration of both the planning and construction phase. The most significant time reduction resulted from less time spent on quality assurance of cost estimates prior to the funding of the projects. Project costs increased in the school case, but were reduced in the prison case. An important challenge faced in both cases is a shallow pool of capable suppliers; the actors have approached the challenge with different strategies, yet neither actor has been successful in their attempts.

Originality/value
The paper provides empirical data to add to the collective knowledge on the project management aspects of using standardized project delivery models and standardized (modular) building. However, by emphasizing the interaction between project delivery models and standardization of the planning and execution of the projects, additional insight into the benefits and challenges are highlighted.
In vogue: demand for scholarly publications among academic librarians
Authors: Quagraine Nana Tuhufo , Agyekum Baffour Ohene 
Published: April 2018

Purpose
The lack of a country-wide data on the extent to which academic librarians in Ghana publish combined with perceived publishing challenges as indicated by a number of scholars including Opoku (2012) leaves much to be desired. Therefore, the purpose of this paper is to seek the views of professional librarians in Ghana on the subject.

Design/methodology/approach
Using a sample size of 45 out of 50 academic librarians who make up the membership of the Consortium of Academic and Research Libraries, the study employed the descriptive survey research strategy in identifying the prospects and challenges associated with academic publications among librarians in Ghana.

Findings
Opportunities for growth, institutional encouragement, requirements for promotion, and opportunities for research training are some of the factors that motivated academic librarians to publish in scholarly journals notwithstanding the pressures to perform their professional duties. Challenges often encountered included lack of research grants, high rejection rate of publishing agencies, lack of research skills and difficulty in getting access to research journals.

Practical implications
On the basis of the above, the establishment of research fund and an award scheme for persons or units with the highest number of publications among others are recommended.

Originality/value
With the exception of cited works, all other forms of this research output are the handiwork of the researchers and have neither been a reproduction of existing research nor ever published in any other journal.
“A feminine brand? Never!” Brands as gender threats for “resistant” masculinities
Authors: Ulrich Isabelle , Tissier-Desbordes Elisabeth 
Published: April 2018

Purpose
The purpose of this paper is to examine the relationships between men and brands and specifically how they configure their masculinities in relation to daily used brands.

Design/methodology/approach
In-depth interviews with projective technique were conducted with 20 men with different masculinities and sexual orientations to explore their practices regarding and relations to various product categories and brands.

Findings
First, this paper shows how men’s relationships to daily used brands vary according to different forms of masculinities, in a continuum apparently disconnected from sexual orientation. Men with “resistant” masculinities are strongly attached to choosing masculine brands; others with more hybrid masculinities are more open to feminine brands and do not care about brand gender. Second, this paper shows the importance of brand gender salience: Men with more traditional masculinities interpret brands through the prism of gender first and over-interpret gendered cues in brand execution. Third, feminine brands are considered as threats for men with traditional masculinities. Fourth, brand extensions to the opposite sex are criticized by men with more traditional masculinities but appreciated by men with hybrid masculinities, independently of sexual orientation.

Originality/value
This paper investigates the relationships between men and brand gender for daily used brands, by introducing a diversity of masculinities. Furthermore, it builds on a qualitative approach to capture individuals’ diverse masculinities. This helps capture the complexity of gender and better understand the relationships between men, masculinities and brands.
Digital Infrastructure as a Determinant of Health Equity: An Australian Case Study of the Implementation of the National Broadband Network
Authors: Schram Ashley , Friel Sharon , Freeman Toby , Fisher Matthew , Baum Fran , Harris Patrick 
Published: April 2018

AbstractInequities in access to fast and reliable internet connections, essential for digital access to services and information that are important for health, can exacerbate social inequalities in health. We evaluated the social equity of the rollout of the National Broadband Network (NBN) in Australia based on the type of digital infrastructure delivered to areas of varying socioeconomic status. We found that areas of greater socioeconomic disadvantage were significantly less likely to receive the highest quality infrastructure, controlling for level of remoteness. These social inequities in provision of quality infrastructure will shape and possibly exacerbate inequities in health. In our discussion we consider how political decisions have obstructed equitable implementation of the policy. Lessons from the Australian case study may be valuable for other countries investing in public digital infrastructure who want to ensure equity of provision and can also inform Australian policy in the NBN's remaining rollout.
Transforming accounting curricula to enhance integrative learning
Authors: Dean Bonnie Amelia , Perkiss Stephanie , Simic Misic Milica , Luzia Karina 
Published: April 2018

AbstractHigher education is fundamental to the accounting profession. However, increased competition, the need to shape responsible global citizens and global influences impacting the profession have highlighted weaknesses in existing accounting curricula with regard to non‐technical skills, professional values and ethics. This paper reports on an approach to improve student learning in a first‐year undergraduate accounting subject through scholarship of teaching and learning and critical participatory action research. The paper highlights the importance of embedding opportunities for integrative learning in accounting curricula to enable students’ developing professional competencies and lifelong learning. It also provides a model for accounting educators to enhance integrative capabilities in their courses through engagement with scholarly research on teaching.
Florivorous myrmecophilous caterpillars exploit an ant–plant mutualism and distract ants from extrafloral nectaries
Authors: Alves‐Silva Estevao , Bächtold Alexandra , Del‐Claro Kleber 
Published: April 2018

AbstractFemales of myrmecophilous butterflies tend to oviposit in plants visited by ant species that engage in stable associations with its larvae. In Banisteriopsis malifolia, caterpillars are attended by the same ants that feed on extrafloral nectaries. A conflict may arise when both the plant and caterpillars compete for ant attention, and ants are assumed to forage on the highest quality resource. By attending caterpillars, ants can be indirectly detrimental to plant fitness because florivorous larvae feed intensively until pupation. In this study, we specifically investigated (i) whether the occurrence of facultative myrmecophilous Synargis calyce (Riodinidae) caterpillars in B. malifolia was based on ant species (Camponotus blandus or Ectatomma tuberculatum) and abundance; (ii) the monopolization of ants by the butterfly larvae and (iii) the florivory rates incurred by the caterpillars on inflorescences. The abundance of S. calyce was six‐fold greater in plants with C. blandus, compared to E. tuberculatum treatments. Caterpillars monopolized up to 50% of C. blandus on the plants, indicating that the resources offered by S. calyce were more attractive to ants than extrafloral nectaries. Florivory by riodinids incurred losses of almost 60% of flower buds. Myrmecophilous riodinids exploited an ant–plant mutualism by attracting aggressive ants that become larvae bodyguards. Thus, this ecological interaction is potentially detrimental to B. malifolia, since the ants, which can provide protection against herbivores, shift to provide defence for one of these herbivores.
Abundance, density and activity ofSalvator merianae(Reptilia: Teiidae) and the effect of poaching on the site occupancy by the lizard in an Atlantic Forest Reserve, Brazil
Authors: Ferreguetti Átilla Colombo , Pereira‐Ribeiro Juliane , Bergallo Helena Godoy , Rocha Carlos Frederico Duarte 
Published: April 2018

AbstractWe aimed to estimate the density, occupancy and detectability ofSalvator merianae(Tegu) in one of the largest Atlantic rainforest remnants in Espírito Santo, Brazil, theVNR. Species patch occupancy was modelled and used to predict the response direction of six covariates based on prior knowledge of the Tegu's ecology.A priori, we expected that the covariates measured should represent key habitat features for the species (i.e. temperature, forest edge, open habitats) or elements possibly avoided by the species, based on the hypothesis that poaching would have a negative effect on patch occupancy. We used line‐transect surveys to estimate density and abundance. Camera‐traps were used to estimate patch occupancy by the Tegu. Estimated density forS. merianaewas 0.21 ± 0.02 Tegus/ha and estimated population size was 4990 ± 521 individuals. Patch occupancy was best described by two covariates: poaching intensity and distance to the forest edge. Detectability was affected by three covariates: poaching intensity, tree density and temperature. Our study presents robust information on abundance and density, habitat use, and activity ofS. merianaein theVNRand is the first study providing data on the effects that poaching has on patch occupancy of this lizard. The data indicated that the occupancy and detectability of this species were influenced by a set of factors, providing information that can be useful in management plans in areas where this species can potentially decline and in areas where it may be introduced.
Extrafloral nectar as a driver of arboreal ant communities at the site‐scale in Brazilian savanna
Authors: Ribeiro Laila Fieto , Solar Ricardo R. C. , Muscardi Dalana C. , Schoereder José H. , Andersen Alan N. 
Published: April 2018

AbstractDespite years of study, it remains unclear if and to what extent the effects of extra‐floral nectaries (EFNs) on arboreal ants observed on individual trees scale up to larger spatial scales. Here, we address this issue in Brazilian savanna and tested three predictions: (i) Trees with EFN have higher richness of arboreal ant species than trees without; (ii) Arboreal ant species richness increases with the proportion of total EFN‐bearing trees at the site scale, due to a higher occurrence of non‐core ant species; (iii) Ant species composition changes with the proportion of EFN‐bearing trees at the site scale. We sampled arboreal ants in 32 plots with EFN‐bearing trees ranging from 0% to 60% of all trees. We sampled 72 ant species, from which 17 (mostly belonging to Camponotus, Cephalotes and Crematogaster) were identified as core species in at least one of the ant‐EFN networks in the 32 plots. Ant species richness was significantly higher on EFN‐bearing trees. We identified 11 ant species that preferentially occurred on EFN‐bearing trees, all of which were core partners in networks. Species richness at the site scales increased with the proportion of EFN‐bearing trees, regardless of tree density and richness; this pattern was due to a higher occurrence of non‐core ant species. Finally, species composition also varied with the proportion of EFN‐bearing trees. Therefore, we found that the presence of EFNs not only influences arboreal ants on individual trees but also has a substantial effect on the ant‐EFN network on a broader community scale. The increase in non‐core species site scale reveals that this interaction is unlikely to result in substantially enhanced protection services for EFN‐bearing plants.
Allergen‐specific immunotherapy induces regulatory T cells in an atopic dermatitis mouse model
Authors: Shin J. U. , Kim S. H. , Noh J. Y. , Kim J. H. , Kim H. R. , Jeong K. Y. , Park K. H. , Lee J. , Chu H. , Lee J.‐H. , Yong T.‐S. , Park J.‐W. , Lee K. H. 
Published: April 2018

AbstractBackgroundSeveral studies have demonstrated that allergen‐specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD.MethodsNC/Nga mice with induced AD‐like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae [DfE]) or placebo for 5 weeks). Clinical and histological improvements of AD‐like skin lesions were examined. The responses of local and systemic regulatory T (Treg) cells, natural killer (NK) cells, B cells, serum immunoglobulin, and T‐cell cytokine response to DfE were evaluated to determine the underlying mechanism of the observed results.ResultsSpecific immunotherapy significantly improved AD‐like skin lesions. Histologically, SIT decreased epidermal thickness and reduced inflammatory cell infiltration, especially that of eosinophils. Concomitantly, SIT suppressed Th2 responses and induced local infiltration of Treg cells into the skin. Also, SIT induced the immunoglobulin G4 and attenuated allergen‐specific immunoglobulin E. Furthermore, SIT induced local and systemic IL‐10‐producing Treg cells and regulatory NK cells.ConclusionWe established a SIT model on AD mice and showed that our model correlates well with previous reports about SIT‐treated patients. Also, we revealed NK cells as another possible resource of IL‐10 in SIT. Based on our results, we suggest our SIT model as a useful tool to investigate mechanism of action of SIT and to validate the efficacy of new SIT modalities for the treatment of AD.
Survey of rabies vaccination status of Queensland veterinarians and veterinary students
Authors: Mendez D , Foyle L , Cobbold R , Speare R 
Published: April 2018

BackgroundTo determine the rabies vaccination status of Queensland veterinarians and veterinary students and their perception of zoonotic risk from Australian bat lyssavirus (ABLV).DesignCross‐sectional questionnaire surveys.MethodsQuestionnaires were sent by post in 2011 to veterinary surgeons registered in Queensland, to final‐year veterinary students at James Cook University via SurveyMonkey® in 2013 and to final‐year veterinary students at James Cook University and University of Queensland via SurveyMonkey® in 2014.ResultsThe response rate for registered veterinarians was 33.5% and for veterinary students 33.3% and 30% in 2013 and 2014, respectively. Of the 466 registered veterinary surgeons, 147 (31.5%) had been vaccinated, with 72 (15.5%) currently vaccinated. For veterinary students the rabies vaccination rate was 20.0% (4/20) and 13.0% (6/46) in the 2013 and 2014 surveys, respectively. More than 95% of veterinary students had received the mandatory Q fever vaccine. Both veterinarians and students regarded bats and horses as high‐risk species for zoonoses.ConclusionsQueensland veterinarians and veterinary students have low levels of protection against ABLV. Although incidents of ABLV spilling over from a bat to a domestic mammal are likely to remain rare, they pose a significant human health and occupational risk given the outcome of infection in humans is high consequence. Principals of veterinary practices and veterinary authorities in Australia should implement a policy of rabies vaccination for clinical staff and veterinary students.
EWSR1‐PATZ1 gene fusion may define a new glioneuronal tumor entity
Authors: Siegfried Aurore , Rousseau Audrey , Maurage Claude‐Alain , Pericart Sarah , Nicaise Yvan , Escudie Fréderic , Grand David , Delrieu Alix , Gomez‐Brouchet Anne , Le Guellec Sophie , Franchet Camille , Boetto Sergio , Vinchon Matthieu , Sol Jean‐Christophe , Roux Franck‐Emmanuel , Rigau Valérie , Bertozzi Anne‐Isabelle , Jones David T. W. , Figarella‐Branger Dominique , Uro‐Coste Emmanuelle 
Published: April 2018

AbstractWe investigated the challenging diagnostic case of a ventricular cystic glioneuronal tumor with papillary features, by RNA sequencing using the Illumina TruSight RNA Fusion panel. We did not retrieve the SLC44A1‐PRKCA fusion gene specific for papillary glioneuronal tumor, but an EWSR1‐PATZ1 fusion transcript. RT‐PCR followed by Sanger sequencing confirmed the EWSR1‐PATZ1 fusion. It matched with canonic EWSR1 fusion oncogene, juxtaposing the entire N‐terminal transcriptional activation domain of EWSR1 gene and the C‐terminal DNA binding domain of a transcription factor gene, PATZ1. PATZ1 protein belongs to the BTB‐ZF (broad‐complex, tramtrack and bric‐à‐brac ‐zinc finger) family. It directly regulates Pou5f1 and Nanog and is essential to maintaining stemness by inhibiting neural differentiation. EWSR1‐PATZ1 fusion is a rare event in tumors: it was only reported in six round cell sarcomas and in three gliomas of three exclusively molecular studies. The first reported glioma was a BRAFV600E negative ganglioglioma, the second a BRAFV600E negative glioneuronal tumor, not otherwise specified and the third, very recently reported, a high grade glioma, not otherwise specified. In our study, forty BRAFV600E negative gangliogliomas were screened by FISH using EWSR1 break‐apart probes. We performed methylation profiling for the index case and for seven out of the ten FISH positive cases. The index case clustered apart from other pediatric low grade glioneuronal entities, and specifically from the well‐defined ganglioglioma methylation group. An additional pediatric intraventricular ganglioglioma clustered slightly more closely with ganglioglioma, but showed differences from the main ganglioglioma group and similarities with the index case. Both cases harbored copy number variations at the PATZ1 locus. EWSR1‐PATZ1 gene fusion might define a new type of glioneuronal tumors, distinct from gangliogliomas.