bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal changes in corticosteroid dose during ibrutinib treatment in patients with cGVHD and pulmonary involvement
Authors: Toyosaki Masako , Machida Shinichiro , Tomizawa Daisuke , Okada Masaya , Sawa Masashi , Ueda Yasunori , Omi Ai , Koroki Yosuke , Teshima Takanori 
Published: December 2024

Abstract
The GVH3001 study assessed the efficacy and safety of ibrutinib in Japanese patients with steroid-dependent or -refractory chronic graft-versus-host disease (cGVHD). However, the effects of ibrutinib on lung function and reduction in corticosteroid dose, which is a measurable factor associated with improved quality of life, could not be adequately assessed in patients who initially presented with lung involvement. This post hoc analysis aimed to evaluate temporal changes in daily corticosteroid dose, as well as effectiveness outcomes based on lung function and symptom burden (percent predicted forced expiratory volume in 1 s [%FEV1] and Lee cGVHD Symptom Scale lung subscale score, respectively) in the subgroup of patients with cGVHD who had lung involvement at baseline. Seven of the 19 patients in the GVH3001 study had lung involvement at baseline. The daily corticosteroid dose for cGVHD decreased in five of these patients, and %FEV1 remained relatively stable in two patients but increased to > 80% in one patient. Lee cGVHD Symptom Scale scores were relatively stable throughout the study in patients with lung involvement. Ibrutinib may allow corticosteroid dose reduction without worsening lung function or increasing symptom burden in previously treated patients with cGVHD and associated lung involvement.
Preparing the certification of software as a medical device: a european regulatory analysis and case study on the Clynx®Platform
Authors: Lopes Irina E. , Pinto Joana F. , da Silva Hugo P. , Chambel Gonçalo , Clemente Carolina , Silva Diogo C. F. , Montes António M. , Simões Daniela 
Published: December 2024

Abstract

Purpose:
The primary objective of this study is the preparation of the certification of the Clynx® Platform, a physiotherapy software, as a Class IIa medical device software in accordance with the regulatory framework outlined in Medical Device Regulation 2017/745 (MDR).

Methods:
The methodology involves a comprehensive analysis of European Union medical device regulations and guidelines, with a specific focus on the certification process essential for obtaining a Conformité Européenne (CE) marking for Class IIa medical device software. This section explores the intricate aspects of the certification process, emphasizing the compilation of Technical Documentation, the nuances of Clinical Evaluation, and the establishment of a Quality Management System. The approach aligns closely with the stipulations of MDR 2017/745.

Results:
The study includes an industry case study featuring the Clynx® Platform, developed by Clynx® Health. Insights derived from the MDR are applied to categorize an in-development version of the software as a Class IIa medical device. The preparation of certification of this product involves the meticulous creation of Intended Use, Classification, General and Safety Performance Requirements, and Clinical Evaluation files, the presentation of an experimental protocol to validate the software’s technical performance for inclusion in the Clinical Evaluation, and a description of an Internal Audit performed on the Quality Management System.

Conclusion:
The certification of Class IIa medical device software necessitates the compilation of thorough Technical Documentation, including an extensive Clinical Evaluation, and the implementation of a robust Quality Management System. The certification process is conducted in collaboration with Notified Bodies, ensuring adherence to the stringent requirements set forth by the regulatory framework.
Old and new on the Peetre K-functional and its relations to real interpolation theory, quasi-monotone functions and wavelets
Authors: Dalmo Rune , Persson Lars-Erik , Samko Natasha 
Published: December 2024

Abstract
The Peetre K-functional is a key object in the development of the real method of interpolation. In this paper we point out a less known relation to wavelet theory and its applications to approximation theory and engineering applications. As a new basis for further development of these studies we present some known properties in the form appropriate for further applications and then derive new information and prove some new results concerning the K-functional and its close relation to (almost) quasi-monotone functions, various indices and interpolation theory. In particular, we extend and unify some known function parameter generalizations of the standard real interpolation spaces

$$(A_0, A_1)_{\theta ,q}$$

(

A
0

,

A
1

)

θ
,
q

.
Revealing Rubric Relations: Investigating the Interdependence of a Research-Informed and a Machine Learning-Based Rubric in Assessing Student Reasoning in Chemistry
Authors: Martin Paul P. , Kranz David , Graulich Nicole 
Published: December 2024

AbstractValid rubrics facilitate assessing the level of complexity in students’ open-ended responses. To design a valid rubric, it is essential to thoroughly define the types of responses that represent evidence of varying complexity levels. Formulating such evidence statements can be approached deductively by adopting predefined criteria from the research literature or inductively by detecting topics, for example, based on data-driven machine learning (ML) techniques. Investigating the interdependence of such research-informed and ML-based rubrics is key to validating ML-based approaches and enhancing their applicability in formative assessments. This study quantitatively compares a research-informed and an ML-based rubric designed to capture the complexity of students’ reasoning on the relative rate of contrasted reactions in undergraduate organic chemistry. Specifically, we leveraged an ML-based clustering technique to inductively develop a holistic fifteen-category rubric to evaluate students’ open-ended reasoning. Subsequently, we performed a quantitative analysis to examine whether the ML-based rubric and its research-informed counterpart are significantly associated. Our findings indicate that research-informed and ML-based rubrics assess students’ reasoning comparably. Thus, both rubric types are valid for categorizing students’ reasoning, underscoring the applicability of integrating ML techniques into rubric development. Nevertheless, aligning ML-based rubrics with the respective assessment objectives remains crucial. A well-aligned, evidence-based rubric may ultimately ease the analysis of student reasoning.
Targeting Fatty Acid Synthase to Halt Tumor Progression and Enhance Radiosensitivity in Breast Cancer Cells
Authors: Chen Ching-I , Chan Hui-Wen , Shen Ching-Yi , Chuang Hui-Yen 
Published: December 2024

Abstract
Purpose
Breast cancer, the most prevalent cancer among women, is closely linked to abnormal glucose and lipid metabolism, leading to radioresistance by upregulating survival-signaling pathways. Overexpression of fatty acid synthase (FASN), a key enzyme in lipogenesis, results in excessive lipid synthesis in breast cancer. This study evaluated whether FASN inhibition enhanced the radiosensitivity of breast cancer cells and inhibited their progression, potentially uncovering mechanisms for new therapeutic strategies.

Methods
MCF-7 breast cancer cells were treated with the FASN inhibitors orlistat and TVB-3166, and cytotoxicity was assessed using the MTT assay. Protein expression changes, migratory ability, and responses to radiotherapy were analyzed by the Western blotting, Transwell, and MTT assays, respectively. To confirm FASN dependence, MCF-7 cells were infected with shFASN lentivirus to verify the specificity of the observed effects to FASN inhibition.

Results
Both orlistat and TVB-3166 treatments induced significant cell death. Reduced FASN, HKII, pERK, and pAKT expression levels, along with an increased BAX/p-BCL2 ratio, indicate that FASN inhibition disrupted cell proliferation and promoted apoptosis by altering tumor metabolism. Furthermore, decreased MMP9 expression correlated with reduced cell migration after FASN inhibition. Importantly, FASN inhibition significantly and dose-dependently enhanced the radiosensitivity of MCF-7 cells. These findings were validated using shFASN lentivirus, confirming that the observed effects were FASN-dependent.

Conclusion
FASN inhibition limited survival and migration and enhanced radiosensitivity in MCF-7 cells. These findings indicate the potential efficacy of FASN inhibitors as standalone therapies or as adjuncts to radiotherapy for breast cancer.
Chiroptical response of an array of isotropic plasmonic particles having a chiral arrangement under coherent interaction
Authors: Oshikiri Tomoya , Matsuo Yasutaka , Niinomi Hiromasa , Nakagawa Masaru 
Published: December 2024

Abstract
The chirality and chiroptical response of materials have attracted significant attention for their potential to introduce the new science of light-matter interactions. We demonstrate that collective mode formation under modal coupling between localized surface plasmon resonances (LSPRs) with a chiral arrangement and Fabry–Pérot (FP) nanocavity modes can induce chiroptical responses. We fabricated a cluster of isotropic gold nanodisks with a chiral arrangement (gold nano-windmills, Au-NWs) on the FP nanocavities of TiO2 and Au film. The differential absorption of the Au-NWs coupled with the FP nanocavities under left- and right-handed circularly polarized light irradiations in the far field was significantly enhanced compared with the differential absorption without the FP nanocavities. Far- and near-field analyses by numerical simulation revealed that the Au-NWs coupled with the FP nanocavities formed a collective mode in the near field, and the collective mode represented the chiroptical response in the far field. The light field with the large helicity, can be used in chiral light-matter interactions. The concept of collective mode formation using isotropic metal nanodisks coupled with FP nanocavities provides a platform for controlling complex light fields.

Graphical abstract
TB or not TB: emerging mycobacteriaceae detected in a human patient, tree shrews, and soil
Authors: Siew Zhen Yun , Khoo Chia Ting , Ong Ghee Khang , Muhamad Nor Siti Norazlin Binti , Leong Pooi Pooi , Wong Siew Tung , Tan Boon Shing , Leong Chee-Onn , Low Dyoi-E , Voon Kenny 
Published: December 2024

AbstractThis study investigated the extrapulmonary pathogenesis of a novel Mycobacteroides abscessus subsp. massiliense strain in a young adult, manifesting as a chronic cutaneous infection. Epidemiological investigation proposed pathogen transmission via contaminated Java apple fruit, likely facilitated by tree shrews. The strain, identified through next-generation sequencing, demonstrated resistance to 76.7% of tested antibiotics, and potential heteroresistance among the M. abscessus subsp. massiliense subpopulations were suggested. Mycobacteroides abscessus complex (MAC) is a group of non-tuberculous mycobacteria, typically associated with soil and water, and poses significant clinical challenges due to its resistance to conventional treatments and its similarity to Mycobacterium tuberculosis. The findings underscore the necessity for further genetic studies to confirm heteroresistant subpopulations and address the complexities of MAC infections.
Automating the quantification of coastal change using historical aerial photography: A case study along the coastline of county Cork, Ireland
Authors: Chalençon Emma , Cawkwell Fiona , O’Shea Michael , Murphy Jimmy 
Published: December 2024

Abstract
Coastlines worldwide are coming under increasing pressure due to climate change and human activity. Data on shoreline change are essential for coastal managers and when no long-term monitoring programs are implemented and shoreline change is typically on the order of less than 1 m/yr., as observed in Ireland, aerial photography is the most valuable source of information. A well-established literature exists for automated vegetation extraction from digital images based on the near infrared reflectance, but there is less research available on spectrally limited colour photography. This study develops a methodology for automating vegetation line extraction from a series of historical aerial photography of the Cork coastline in the South-West of Ireland. The approach relies on the Normalised Green–Blue Difference Index (NGBDI), which is versatile enough to discriminate disparate coastal vegetation environments, at different resolutions and in various lighting and seasonal conditions. An iterative optimal threshold process and the use of LiDAR ancillary datasets resulted in an automated vegetation line measurement with uncertainties estimated to be between 0.6 and 1.2 m. Change rates derived from the vegetation lines extracted present uncertainties in the range of ±0.27 m/yr. This robust and repeatable method provides a valuable alternative to time-consuming and subjective manual digitisation.
Evaluation of Clinical and Laboratory Findings and Outcomes in Patients Suffering from Earthquake-Related Crush Injury: Who Needs Renal Replacement Therapy?
Authors: Bayyigit Akif , Gunay F. Hande , Yerli Mustafa , Ervatan Zekeriya , Karmis E. Belen , Kadioglu Kocak M. Gulay 
Published: December 2024

Abstract

Objectives
Many people who are rescued alive from rubble after earthquakes suffer from crush injuries and associated acute kidney injury (AKI). McMahon score is used to determine the risk of AKI and mortality due to rhabdomyolysis in hospitalized patients. In this study, we aimed to evaluate the clinical findings, biochemical characteristics, and outcomes of crush injury patients admitted to our tertiary hospital and the use of the McMahon score in determining the need for renal replacement therapy (RRT) in this patient group.

Methods
Sociodemographic, clinical, and biochemical parameters of 28 patients who had creatine kinase levels of 1000 U/L and above were recorded. Patients with crush injuries requiring and not requiring RRT were compared according to the McMahon Score.

Results
A total of 42% of patients developed AKI and 67% of them required renal replacement therapy. In crush injury patients requiring RRT, serum urea, creatinine, LDH, aspartate aminotransferase, alanine transaminase, phosphorus, and procalcitonin levels were significantly higher and albumin levels were significantly lower at admission compared to patients not requiring RRT. All patients who required RRT had a McMahon Score ≥6.

Conclusions
A high McMahon score at hospital admission is associated with an increased need for RRT.
The radical innovation design comparator to evaluate the effectiveness of design solutions according to usage contexts
Authors: Yannou Bernard , Lecomte Robin , Cluzel François 
Published: December 2024

Abstract
The radical innovation design (RID) comparator is an unprecedented method for design comparison. It overcomes the limitations of traditional methods with a nuanced, structured approach that emphasizes detailed analysis over simple grading. At its core, the RID comparator employs a novel ontology based on the RID building blocks, enabling a precise alignment of activities and solutions. This alignment is deepened through the innovative “quantities of pain” metric, a tool that allows for a refined evaluation and comparison of solutions, facilitating the calculation of effectiveness indicators in a data-driven manner. The true impact of the method is demonstrated through an industrial use case on solutions for cleaning solar panels. The RID comparator demonstrates its practical efficacy in addressing complex, multifactorial design challenges, by constructing a cognitive model of the cleaning activity not only encapsulating the myriad aspects of the design problem but also generating a wealth of discussion and consensus-building among stakeholders. The resultant cognitive model serves as a pivotal tool in redefining the process of generating innovation briefs, deeply rooted in the actual needs and constraints of real-world scenarios. In essence, the RID comparator method significantly enhances the efficiency and quality of innovation processes, particularly in complex industrial contexts.
Designing recovery-oriented care: a qualitative study to inform service design at Kyrie Therapeutic Farm in Ireland
Authors: Koretsidou Christina , O’Toole Catriona , Galavan Eoin , McKeon John , McGilloway Sinead 
Published: December 2024

Abstract

Objectives:
Recovery-oriented approaches are gaining increased attention in the mental health sector, including from the World Health Organization and the United Nations, for their potential to support people in recovering and building meaningful lives through strengths-based, person-centered principles. Kyrie Therapeutic Farm (KTF) is a new initiative in Ireland that seeks to develop recovery-oriented model of adult mental health care. The aim of this study was to explore the barriers and facilitators of recovery-oriented models of practice in a small number of therapeutic farm settings across the world in order to inform service design at KTF whilst also addressing a gap in research on this topic.

Methods:
Three semi-structured focus-group interviews were conducted online via MS Teams with ten staff members in different roles and years of experience from three existing therapeutic community farms. reflexive thematic analysis was employed for data analysis.

Results:
Four themes emerged that illustrate how therapeutic farm communities operate in general and specifically in relation to recovery: 1. common humanity, 2. freedom and responsibility, 3. interdependence and community living, and 4. learning organisations.

Conclusion:
This study demonstrates the viability of recovery-oriented practices in community therapeutic farms, including KTF, thereby contributing to the broader trend toward more person-centered mental health services. The values inherent in the recovery-oriented approach – such as community, empowerment, and close, equitable, non-hierarchical relationships – act as facilitators. However, embedding these values in practice can generate tensions for staff which warrant attention. Implications for the integration into service design of KTF and further research are offered.
Greek physician Asclepiades of Bithynia (124–40 BC) and his contribution to thinking about mental illness and its treatment
Authors: Brady Frank A. , Kelly Brendan D. 
Published: December 2024

Abstract

Objectives:
To outline the life and work of Greek physician Asclepiades of Bithynia (124–40 BC), especially his contributions to thinking about mental illness.

Methods:
Review and discussion of relevant fragments of Asclepiades’ work that survive and review of secondary literature, supplemented by relevant systematic literature searches (e.g. PubMed).

Results:
Asclepiades challenged the long-standing Hippocratic doctrine of the four humours and developed an approach to physical and mental illness that was humane, reasoned, and a forerunner of later developments in psychiatry. Asclepiades argued that the human body, like everything in the universe, comprised tiny, imperceptible particles, which he called önkoi, seamless masses in perpetual motion. In consequence, Yapijakis describes Asclepiades as ‘the father of molecular medicine’. Asclepiades held that good health was maintained by free, balanced motion of önkoi through theoretical pores, while disease resulted from blockage or impaction of önkoi passing through pores in various body parts (e.g. brain). Based on this idea, Asclepiades recommended releasing people with apparent mental illness from confinement and using judicious combinations of diet, exercise, massage, bathing, and music to treat ‘phrenitis’ (delirium) and melancholia. He suggested that the physician act ‘safely, swiftly and pleasantly’ (‘cito, tutu, jucunde’) for both physical and mental illness.

Conclusions:
Asclepiades belongs to the historical tradition of progressive medical approaches to mental illness, not least because he applied his principles for the treatment of physical illness to mental illness. His ideas about psychiatry set the scene for further evolution of attitudes to mental illness and its treatment over subsequent centuries.
The Second Coming of Rodina: The Role of a Nonparliamentary Party in Putin’s Managed Nationalism
Authors: Horvath Robert , Lever Charlotte 
Published: December 2024

Abstract
This article examines the unexpected revival of Rodina (Motherland), a nationalist party that had been suppressed in 2006 for its embrace of “orangist,” anti-Putin politics. Five years later, Rodina was relaunched in response to the crisis of the Medvedev–Putin “tandemocracy.” This article shows that Rodina played a central role in the Kremlin’s “managed nationalism,” which sought to direct the energies of Russian nationalists into loyalist channels. In particular, it illuminates three ways that Rodina facilitated collaboration between nationalists and the regime. First, it helped to integrate nationalists into the All-Russia Popular Front, the umbrella structure that was created as a vehicle for Putin’s return to the presidency. Second, it served as a counterrevolutionary force by drawing nationalists from the “white ribbon” protest movement into two Kremlin-supported initiatives: the “conservative turn” and a media campaign against non-Slavic immigration. And third, it acted as a proxy for the Russian state during the annexation of Crimea and the conflict in southeast Ukraine, recruiting nationalists to serve as separatists and cultivating the support of European radical nationalists. In these three ways, Rodina contributed both to Russia’s autocratization and to the growing influence of nationalist ideas in public discourse.
Moderate Physical Perspectivalism
Authors: Adlam Emily 
Published: December 2024

Abstract
Recent developments in foundations of physics have given rise to a class of views suggesting that physically meaningful descriptions must always be relativized to a physical perspective. In this article I distinguish between strong physical perspectivalism, which maintains that all facts must be relativized to a perspective, and moderate physical perspectivalism, which maintains that all empirically meaningful descriptions must be relativized to a perspective. I argue that scientific evidence and philosophical considerations support moderate physical perspectivalism over strong physical perspectivalism. In particular, motivations connected to epistemic humility and the social nature of science are more compatible with the moderate approach.
Europeans’ attitudes toward the EU following Russia's invasion of Ukraine
Authors: Unan Asli , Klüver Heike 
Published: December 2024

Abstract
The Russian invasion of Ukraine in February 2022 has had profound effects on the stability and security of Europe. This study examines the attitudes of Europeans toward the European Union (EU) in the aftermath of the invasion of Ukraine. Using Special Eurobarometer data collected between February and April 2022 with a representative sample of the EU (N = 26,502), it leverages the quasi-experimental setting with the coincidence between the timing of the invasion and the fieldwork period of the Eurobarometer. Our findings indicate a general increase in support for the EU in the aftermath of the invasion by 4 percentage-points (11 percent of a SD). While the amplitude of the effect remains similar, we see larger treatment effects as more days passed after the invasion. We also observe significant variation at the individual level in treatment effects, particularly by ideology, with left-leaning individuals being more critical of the EU following the invasion. In general, our research demonstrates the significant impact of regional conflicts on public attitudes toward supranational organizations such as the EU and highlights the role of the EU as a provider of security and stability in the face of such conflicts.