bluuebunny/crossref_metadata_2025_split huggingface dataset:
TSLP-mediated inflammatory factors production contributes to metastatic breast cancer-induced bone cancer pain in mice
Authors: Chen Ying , Xian Pei-Feng , Wang Sheng-Xu , Yang Lu 
Published: September 2018

AbstractObjective:Metastatic breast cancer-induced bone cancer pain (BCP) is one of the most disabling factors in patients suffering. Recent studies show thymic stromal lymphopoietin (TSLP) is a proinflammatory factor and high expression in cancer cells. Here we investigated whether and how TSLP released form breast cancer cells contributes to BCP.Methods:Braset cancer cells MDA-MB-231 were intramedullary injected into the femur to induce BCP, TSLP neutralizing antibody was intrathecally injected and pain hypersensitivity was checked by behavioral testing. The TSLP expression was knockdown by shRNA. Human TSLP, TNF-α, IL-1β, IL-6, CCL2, CXCL2 and CXCL5 in intramedullary space of the femur of rats was detected by ELISA.Results:TSLP neutralizing antibody intrathecally injection significantly reduced MDA-MB-231 cells inoculation induced persistent mechanical allodynia and heat hyperalgesia and TSLP increased. Furthermore, Persistent mechanical allodynia and heat hyperalgesia of mice models were also decreased in MDA-MB-231 cells with TSLP knockdown. Finally, some inflammatory factors, TNF-α, IL-1β, IL-6, CCL2, CXCL2 and CXCL5 were significantly elevated in the intramedullary space lavage fluid of the right femur after cancer cell inoculation, but were obviously reduced in models with neutralizing antibody of TSLP treatment and TSLP knockdown.Conclusion:TSLP-mediated inflammatory factors release contributes to the maintenance of tumoral hypersensitivity. Inhibition of the TSLP may provide a new therapy for BCP management.
Elimination of ribosome inactivating factors improves the efficiency ofBacillus subtilis and Saccharomyces cerevisiaecell-free translational systems
Authors: Brodiazhenko Tetiana , Johansson Marcus , Takada Hiraku , Nissan Tracy , Hauryliuk Vasili , Murina Victoriia 
Published: September 2018

AbstractCell-free translational systems based on cellular lysates optimized forin vitroprotein synthesis have multiple applications both in basic and applied science, ranging from studies of translation regulation to cell-free production of proteins and ribosome-nascent chain complexes. In order to achieve both high activity and reproducibility in a translational system, it is essential that the ribosomes in the cellular lysate are enzymatically active. Here we demonstrate that genomic disruption of genes encoding ribosome inactivating factors – HPF inBacillus subtilisand Stm1 inSaccharomyces cerevisiae– robustly improve the activities of bacterial and yeast translational systems. A possible next step in developing strains for production of even more efficient cell-free translation systems could be achieved by combining a genomic disruption of the ribosome hibernation machinery with inactivation of the genes responsible for proteolysis and RNA degradation.
Field assessment of precocious maturation in salmon parr using ultrasound imaging
Authors: Nevoux Marie , Marchand Frédéric , Forget Guillaume , Huteau Dominique , Tremblay Julien , Destouches Jean-Pierre 
Published: September 2018

AbstractSalmonids are characterized by a large diversity of life histories, but their study is often limited by the imperfect observation of the true state of an individual in the wild. Challenged by the need to reduce uncertainty of empirical data, recent development in medical imaging techniques offered new opportunities to assess precocious maturation in Atlantic salmon parr. Traditional phenotypic (external) examination and ultrasound (internal) examination were compared and recommendations on fish handling and ultrasound image interpretation are provided. By allowing to see the unseen, portable ultrasound imaging offers great opportunities for ecological studies in the wild, such as the assessment of individual sexual maturation.
Assessing the satisfaction of teenagers at risk and vulnerable to social damages of young adults’ publications in Iran based on the CSI model
Authors: Amini Mahsa , Pashootanizadeh Mitra 
Published: September 2018

Purpose
The purpose of this paper is to assess the satisfaction of teenagers who are suffering from or are exposed to social damages of children and young adults’ publications in Iran.

Design/methodology/approach
A descriptive surveys approach with practical purposes is applied here. The tools used in this study include two researcher-made questionnaires. Two sets of participants constitute the statistical populations: 120 and 50 teenagers who were affected by or are at the risk of social damages. Data collection from the first set was through census, while the same from the second set is through the disproportionate stratified random sampling method. Another statistical population is the group of premier children publishers during 2006-2016.

Findings
The teenagers’ satisfaction mainly is involved with: perceived quality, expectations and perceived value. “Music” and “Recreational and performing arts”, internet-based resources, “Electronic materials” and “Real stories” are ranked as having the highest mean value in information needs, formats and literacy genre among teenagers, respectively. The findings here indicate that the teenagers participated are satisfied with children publications to a great extent.

Originality/value
This is the first research which used the CSI Model for assessing the satisfaction of teenagers at risk and vulnerable to social damages.
Predicting students’ intention to adopt mobile learning
Authors: Buabeng-Andoh Charles 
Published: September 2018

Purpose
The purpose of this paper is to explore the ability of the integration of technology acceptance model (TAM) and theory of reasoned action (TRA) to predict and explain university students’ intention to use m-learning in schools.

Design/methodology/approach
In total, 487 students participated in this study. A seven-likert scale survey questionnaire which comprised of 23 items was completed by the students. Structural equation modeling was used as the statistical technique to analyze the data.

Findings
The study found that the resulting model was fairly able to predict and explain behavioral intention (BI) among students in Ghana. In addition, this study found that attitudes toward use and subjective norm significantly influenced students’ BI to use mobile learning. The model explained 23.0 percent of the variance in BI, 33.8 percent in perceived usefulness and 47.6 percent in attitudes toward use. Of all the three endogenous variables, attitude had the greatest effect on BI.

Originality/value
Although, the above-mentioned models have been adopted in many studies, few or none have combined TRA and TAM as a research framework to predict and explain students’ intention to use m-learning since m-learning is fairly new in educational environments. Therefore, a model that combines all constructs from TRA and TAM was proposed in this study to explore university students’ intention to use m-learning in schools.
Are sustainable luxury goods a paradox for millennials?
Authors: Rolling Virginia , Sadachar Amrut 
Published: September 2018

PurposeThe purpose of this study is to examine how luxury brand descriptions influence millennials’ impression of luxury, impression of sustainability, attitude toward brand and purchase intention using the impression formation theory.Design/methodology/approachA between-subjects experimental design was used to test the research model, wherein two randomly assigned groups received an online experiment with either a luxury-only or a sustainable-luxury brand description.FindingsFindings included that the impression of luxury did not change for a sustainable-luxury brand describing the use of recycled materials as compared to a luxury-only brand without the description of recycled materials present. Therefore, millennials perceived the luxury-only and sustainable-luxury brands to provide an impression of luxury, which was the sole impression to significantly predict attitude toward the brand. In addition, the results indicated that attitude positively influenced purchase intention for both brand descriptions.Originality/valueThis study provides support for luxury brands to transition toward sustainable efforts of using recycled materials in their goods as the impression of luxury is preserved, and provide marketing communication that favors sustainable brand positioning. This is one of the first empirical studies that focused on exploring sustainability strategies for luxury brands targeting a specific market segment (i.e. millennials in the United States of America).
Review Paper: Post‐stack 4D seismic time‐shifts: Interpretation and evaluation
Authors: MacBeth Colin , Mangriotis Maria‐Daphne , Amini Hamed 
Published: September 2018

ABSTRACTA review and analysis of post‐stack time‐lapse time‐shifts has been carried out that covers published literature supplemented by in‐house datasets available to the authors. Time‐shift data are classified into those originating from geomechanical effects and those due to fluid saturation changes. From these data, conclusions are drawn regarding the effectiveness of post‐stack time‐shifts for overburden and reservoir monitoring purposes. A variety of field examples are shown that display the range and magnitude of variation for each class of application. The underlying physical mechanisms creating these time‐shifts are then described, and linked to a series of generic and field‐specific rock physics calculations that predict their magnitudes. These calculations serve as a guide for practitioners wishing to utilize this information on their own datasets. Conclusions are drawn regarding the reliability of this attribute for monitoring purposes, and the extent to which further development is required and how it should be reported by authors.
Three‐dimensional magnetotelluric responses for arbitrary electrically anisotropic media and a practical application
Authors: Yu Guo , Xiao Qibin , Zhao Guoze , Li Man 
Published: September 2018

ABSTRACTElectrical anisotropy in earth media increases the complexity of magnetotelluric responses. Magnetotelluric models based on anisotropic media must be developed to fully understand observed data. This paper presents a three‐dimensional algorithm for calculating magnetotelluric responses of arbitrary anisotropic media in the frequency domain. Using a staggered‐grid finite difference method, the model space is discretized into rectangular blocks with electric fields on the edges of each block and the magnetic fields normal to the faces of each block. The electric field Helmholtz vector equation that considers a full 3 × 3 conductivity tensor is calculated numerically under two orthogonal polarizations. In calculating the boundary values on the four sides of the three‐dimensional anisotropic model, we adopt different procedures for calculating the two‐dimensional responses on the sides in the x and y directions. The responses for a layered anisotropic model and a three‐dimensional isotropic model calculated with this algorithm are compared with the corresponding analytical and numerical solutions, respectively. The comparisons show that the algorithm's approximations are highly precise for a wide frequency band. A typical two‐dimensional anisotropic model and a general three‐dimensional anisotropic model were also constructed, and their responses were calculated. These anisotropic models have ordinary structures but can produce phase rolling out of quadrant magnetotelluric responses, which indicates that considering electrical anisotropy may improve our interpretation of observed data. Using this algorithm, we can model the observed data from the northern Qaidam Basin in northern Tibet, where ultrahigh‐pressure metamorphic rocks are exposed along an old suture, and seismic anisotropy was indicated in neighbouring areas. The phase tensors of the magnetotelluric sites at this location show large skew angles, and the corresponding phase splits are distinct in the off‐diagonal impedance elements. Although the isotropic three‐dimensional electrical structure can model the profile data well, the structure shows a sequence of conductive and resistive bodies in the mid‐lower crust of the north Qaidam Basin, which is very spatially inhomogeneous, and a simple intrinsic anisotropic body can also produce similar surficial responses. Using the three‐dimensional anisotropic algorithm, we found an equivalent anisotropic replacement for this area. The results of the three‐dimensional anisotropy modelling of the magnetotelluric data from the northern Tibetan Plateau show the valuable applicability of the three‐dimensional anisotropic algorithm in testing the qualitative presumption of electrical anisotropy.
Effects of zooplankton carcasses degradation on freshwater bacterial community composition and implications for carbon cycling
Authors: Kolmakova Olesya V. , Gladyshev Michail I. , Fonvielle Jérémy André , Ganzert Lars , Hornick Thomas , Grossart Hans‐Peter 
Published: September 2018

SummaryNon‐predatory mortality of zooplankton provides an abundant, yet, little studied source of high quality labile organic matter (LOM) in aquatic ecosystems. Using laboratory microcosms, we followed the decomposition of organic carbon of fresh 13C‐labelled Daphnia carcasses by natural bacterioplankton. The experimental setup comprised blank microcosms, that is, artificial lake water without any organic matter additions (B), and microcosms either amended with natural humic matter (H), fresh Daphnia carcasses (D) or both, that is, humic matter and Daphnia carcasses (HD). Most of the carcass carbon was consumed and respired by the bacterial community within 15 days of incubation. A shift in the bacterial community composition shaped by labile carcass carbon and by humic matter was observed. Nevertheless, we did not observe a quantitative change in humic matter degradation by heterotrophic bacteria in the presence of LOM derived from carcasses. However, carcasses were the main factor driving the bacterial community composition suggesting that the presence of large quantities of dead zooplankton might affect the carbon cycling in aquatic ecosystems. Our results imply that organic matter derived from zooplankton carcasses is efficiently remineralized by a highly specific bacterial community, but does not interfere with the bacterial turnover of more refractory humic matter.
The Effects of Analyst‐Country Institutions on Biased Research: Evidence from Target Prices
Authors: BRADSHAW MARK T. , HUANG ALAN G. , TAN HONGPING 
Published: September 2018

ABSTRACTPrior research demonstrates that a strong institutional infrastructure in a country moderates self‐serving behavior of market participants. Cross‐country economic activities have increased significantly, presenting a research opportunity to examine the relative influence of local versus foreign institutional infrastructure on individual market participants. We utilize variation in analyst‐country location relative to covered firm location to examine institutional determinants of optimism in analyst research. Focusing on target prices, where persistent optimism is well documented, we find that analysts domiciled in countries with stronger institutional infrastructures exhibit significantly attenuated target price optimism and more value‐relevant target prices. Our results demonstrate the importance of domestic country‐level institutional factors in moderating self‐serving behavior of market participants engaged in cross‐country activities.
Corpse Dismemberment and a Necrofetishist
Authors: Pettigrew Mark 
Published: September 2018

AbstractA case of postmortem dismemberment and evisceration is presented. Over a 5‐year period, a serial killer murdered twelve men, with a necrophilic intent, so he could mimic relationship behaviors with the corpses of those he killed. Analysis of the methods he chose to dispose of his victims reveals a stark contrast to the motive for perpetrating the homicides, methods which are suggestive of anger toward the victim when they could no longer fulfill their role in the necrophile's fantasy.
The Effect of Household Oxidizing Cleaners on Chemiluminescence of Blood Using Bluestar®
Authors: Adams Joshua L. , Rancourt Emily D. , Christensen Angi M. 
Published: September 2018

AbstractThis study tests the effect of three common oxidizing cleaners on the ability of the Bluestar Forensic® presumptive test for blood to identify the presence of blood on ceramic tile after cleaning. The cleaners tested were Lysol®, OxiClean®, and Arm & Hammer®. This study also tested which cleaner was the most effective at removing blood, measured by the intensity of chemiluminescence, which was quantified using RGB values in ImageJ. A “hasty” 1‐min cleaning of a blood droplet was simulated using the three cleaners. The chemiluminescence of the Bluestar® reactions after cleaning the blood‐treated region was compared to an untreated region of the same tile for each cleaner, as well as to the treated regions of tiles between the three cleaners. Results indicate that none of the three cleaners removed all of the blood (all p < 0.001) and that Lysol® removed more blood compared to the OxiClean® and Arm & Hammer®.
Process of knowledge translation within routine clinical care: Implementing best practice in weight management
Authors: Wilkinson Shelley A. , Hughes Elyssa , Moir Jessica , Jobber Chloe , Ackerie Antoinette 
Published: September 2018

AimFailure to translate research into practice is common. The present study implemented an evidence‐based model of care to address identified evidence‐practice gaps in our department's weight management service.MethodsImplementation science frameworks were used to identify barriers to best practice and determine appropriate strategies to overcome them. No practice change occurred pre‐implementation. The new model of care incorporated evidence‐based interventions into a flowchart, supported by written resources, and integrated routine data collection into clinic processes. Alignment with a statewide telephone counselling program enhanced service capacity. Data were collected for adult patients whose primary intervention was weight management at a South‐East Queensland hospital and included service attendance metrics, anthropometry, diet quality, and interventions delivered, and were compared with guidelines. Change in outcomes was calculated at 3 months after initial appointments.ResultsPre‐implementation, 69.2% (n = 91) of patients referred were seen by a dietitian. During the new model of care (n = 60), over half (63.3%) were referred to telephone counselling. The remainder were triaged according to the flowchart with 100% attendance. Guideline adherence for reviews significantly increased over time (4.4%–50%, P < 0.001). Follow‐up data were available for 31.3% and 54.5% of the pre‐implementation and new model of care patients, respectively. No significant differences were observed between outcomes.ConclusionsThe present study demonstrated successful implementation of weight management guidelines within routine clinical care. Following a systematic assessment of existing evidence‐practice gaps resulted in a pragmatic evidence‐based model of care that could be delivered within service capacity.
Re‐evaluating the nutritional awareness, knowledge and eating behaviours of women attending a tertiary maternity hospital following iterative service redesign
Authors: Wilkinson Shelley A. , Donaldson Elin , McCray Sally J. 
Published: September 2018

AimSince the opening of the new Mater Mothers' Hospital in 2008, innovative initiatives were developed, implemented and evaluated to meet women's nutritional needs. This study evaluated changes in women's nutritional awareness, knowledge and behaviours and compared these data with our baseline survey.MethodsDuring 2014–2017, 421 postnatal women were surveyed across nine survey periods. Results were compared with those from our 2008 survey (n = 102). Surveys assessed nutrition knowledge, attitudes, behaviour, education preferences, and dietetic service awareness and were distributed on meal trays.ResultsA greater proportion of women accessed the nutrition services in 2014–2017 compared with 2008 (19.7% vs 9.9%) and rated the resources favourably (≥3.5 out of 5). A similar proportion rated the importance of eating well postnatally (83.1% vs 92.1%) and returning to their pre‐pregnancy weight (62.4% vs 68.3%) as important/very important. In both periods, women had poor diet quality, despite identifying healthy eating as a high priority. A reduction in median gestational weight gain (GWG) approached significance, 13.0 kg (2014–2017) versus 14.0 kg (2008), P = 0.055. There was a significant association between GWG and cohort with an increase in the proportion of women gaining within their correct guidelines (by 15.4%), a reduction of excessive gain (by 24.7%, P < 0.001) over time.ConclusionsEvidence‐based service changes made since 2008 have effected positive change in women's GWG, service preferences, and access. However, women still require awareness‐raising and behaviour change programs to improve diet quality and GWG to ensure optimal pregnancy outcomes.
Using noninvasive metagenomics to characterize viral communities from wildlife
Authors: Bergner Laura M. , Orton Richard J. , da Silva Filipe Ana , Shaw Andrew E. , Becker Daniel J. , Tello Carlos , Biek Roman , Streicker Daniel G. 
Published: September 2018

AbstractMicrobial communities play an important role in organismal and ecosystem health. While high‐throughput metabarcoding has revolutionized the study of bacterial communities, generating comparable viral communities has proven elusive, particularly in wildlife samples where the diversity of viruses and limited quantities of viral nucleic acid present distinctive challenges. Metagenomic sequencing is a promising solution for studying viral communities, but the lack of standardized methods currently precludes comparisons across host taxa or localities. Here, we developed an untargeted shotgun metagenomic sequencing protocol to generate comparable viral communities from noninvasively collected faecal and oropharyngeal swabs. Using samples from common vampire bats (Desmodus rotundus), a key species for virus transmission to humans and domestic animals, we tested how different storage media, nucleic acid extraction procedures and enrichment steps affect viral community detection. Based on finding viral contamination in foetal bovine serum, we recommend storing swabs in RNAlater or another nonbiological medium. We recommend extracting nucleic acid directly from swabs rather than from supernatant or pelleted material, which had undetectable levels of viral RNA. Results from a low‐input RNA library preparation protocol suggest that ribosomal RNA depletion and light DNase treatment reduce host and bacterial nucleic acid, and improve virus detection. Finally, applying our approach to twelve pooled samples from seven localities in Peru, we showed that detected viral communities saturated at the attained sequencing depth, allowing unbiased comparisons of viral community composition. Future studies using the methods outlined here will elucidate the determinants of viral communities across host species, environments and time.