bluuebunny/crossref_metadata_2025_split huggingface dataset:
LAS FUENTES DEL DERECHO DE SOCIEDADES Y LA ORDEN JUS/319/2018, DE 21 DE MARZO
Authors: Embid Irujo José Miguel 
Published: October 2018

Pocos temas serán más clásicos y conocidos para el jurista que el relativo a las fuentes del Derecho, por lo que parece adecuado reflexionar brevemente sobre él a propósito de su relieve en el ámbito específico del Derecho de sociedades.En verdad, no es el de las fuentes un tema que haya preocupado especialmente a los societaristas, quizá porque, en tal disciplina, las mismas sean pocas (o, al menos, no demasiadas), claras en su apariencia y, por lo común, de rango legal. Esta somera descripción, necesitada, claro está, de muchos matices, refleja la tradición específica del Derecho de sociedades entre nosotros, sin perjuicio de su sustancial acomodo a la situación presente. Se comprende, por ello, que el jurista interesado en dicha disciplina asuma con naturalidad ese estado de cosas, sin que se obvien por ello las necesarias matizaciones. Menos acertada es, por lo demás, la ausencia de toda perspectiva crítica, que habría de derivarse inevitablemente de la teoría de las fuentes del Derecho o, tal vez mejor, de la necesidad de disponer de una orientación sólida en nuestro ámbito desde el terreno de la política legislativa.
Aplicación del derecho de la unión europea por el Tribunal de Justicia de la Unión Europea para resolver la cuestión prejudicial sobre la interpretación del artículo 7, apartado 2, primer guión, de la Directiva 86/653/ CEE del Consejo, de 18 de diciembre de 1986, relativa a la coordinación de los derechos de los Estados miembros en lo referente a los agentes comerciales, en el sentido de que el agente comercial encargado de un sector geográfico determinado tiene derecho a una comisión en el caso que se concluya una operación entre un tercero y un cliente perteneciente a este sector sin que el Empresario haya intervenido de forma directa o indireta en dicha operación. Sentencia del Tribunal de Justicia (Sala Primera) de 17 de enero de 2008 (petición de decisión prejudicial planteada por la Cour de cassation — Francia) — Herederos de Paul Chevassus-Marche/ Groupe Danone, Societé Kro beer brands SA (BKSA) y Societé Évian eaux minérales d´Evian SA (SAEME) (Asunto C-19/07)
Authors: Morales Villanueva Paloma 
Published: October 2018

Litigio principal versa sobre el derecho a la comisión debida que reclama el Agente comercial, Paul Chevassus-Marche, parte demandante y recurrente en primera instancia, apelación y casación, al Principal o Empresario, Sociedad Groupe Danone, y sus filiales, Societé Kro beer brands SA (BKSA) y Societé Évian eaux minérales d´Evian SA (SAEME), todas ellas conjuntamente, como parte demandada y recurrida, tras la resolución del Contrato de Agencia Comercial internacional, reclamando el Agente las comisiones relativas a adquisiciones efectuadas por dos sociedades que pertenecían al sector geográfico coincidente con el pactado con el Principal o Empresario, sin el control del Empresario, es decir de Groupe Danone o sus filiales y sin intervención del Agente en las mismas y el consiguiente planteamiento de cuestión prejudicial sobre la interpretación del artículo 7, apartado 2, primer guión de la Directiva 86/653/CEEE del Consejo, de 18 de diciembre de 1986, relativa a la coordinación de los derechos de los Estados miembros en lo referente a los agentes comerciales independientes, sobre el derecho a la comisión.
Predicting culturable enterococci exceedances at Escambron Beach, San Juan, Puerto Rico using satellite remote sensing and artificial neural networks
Authors: Laureano-Rosario Abdiel E. , Duncan Andrew P. , Symonds Erin M. , Savic Dragan A. , Muller-Karger Frank E. 
Published: October 2018

Abstract
Predicting recreational water quality is key to protecting public health from exposure to wastewater-associated pathogens. It is not feasible to monitor recreational waters for all pathogens; therefore, monitoring programs use fecal indicator bacteria (FIB), such as enterococci, to identify wastewater pollution. Artificial neural networks (ANNs) were used to predict when culturable enterococci concentrations exceeded the U.S. Environmental Protection Agency (U.S. EPA) Recreational Water Quality Criteria (RWQC) at Escambron Beach, San Juan, Puerto Rico. Ten years of culturable enterococci data were analyzed together with satellite-derived sea surface temperature (SST), direct normal irradiance (DNI), turbidity, and dew point, along with local observations of precipitation and mean sea level (MSL). The factors identified as the most relevant for enterococci exceedance predictions based on the U.S. EPA RWQC were DNI, turbidity, cumulative 48 h precipitation, MSL, and SST; they predicted culturable enterococci exceedances with an accuracy of 75% and power greater than 60% based on the Receiving Operating Characteristic curve and F-Measure metrics. Results show the applicability of satellite-derived data and ANNs to predict recreational water quality at Escambron Beach. Future work should incorporate local sanitary survey data to predict risky recreational water conditions and protect human health.
[18F]-florbetaben PET/CT Imaging in the Alzheimer’s Disease Mouse Model APPswe/PS1dE9
Authors: Stenzel J. , Rühlmann C. , Lindner T. , Polei S. , Teipel S. , Kurth J. , Rominger A. , Krause B.J. , Vollmar B. , Kuhla A. 
Published: October 2018

Background:Positron-emission-tomography (PET) using 18F labeled florbetaben allows noninvasive in vivo-assessment of amyloid-beta (Aβ), a pathological hallmark of Alzheimer’s disease (AD). In preclinical research, [<sup>18</sup>F]-florbetaben-PET has already been used to test the amyloid-lowering potential of new drugs, both in humans and in transgenic models of cerebral amyloidosis. The aim of this study was to characterize the spatial pattern of cerebral uptake of [<sup>18</sup>F]-florbetaben in the APPswe/ PS1dE9 mouse model of AD in comparison to histologically determined number and size of cerebral Aβ plaques.Methods:Both, APPswe/PS1dE9 and wild type mice at an age of 12 months were investigated by smallanimal PET/CT after intravenous injection of [<sup>18</sup>F]-florbetaben. High-resolution magnetic resonance imaging data were used for quantification of the PET data by volume of interest analysis. The standardized uptake values (SUVs) of [<sup>18</sup>F]-florbetaben in vivo as well as post mortem cerebral Aβ plaque load in cortex, hippocampus and cerebellum were analyzed.Results:Visual inspection and SUVs revealed an increased cerebral uptake of [<sup>18</sup>F]-florbetaben in APPswe/ PS1dE9 mice compared with wild type mice especially in the cortex, the hippocampus and the cerebellum. However, SUV ratios (SUVRs) relative to cerebellum revealed only significant differences in the hippocampus between the APPswe/PS1dE9 and wild type mice but not in cortex; this differential effect may reflect the lower plaque area in the cortex than in the hippocampus as found in the histological analysis.Conclusion:The findings suggest that histopathological characteristics of Aβ plaque size and spatial distribution can be depicted in vivo using [<sup>18</sup>F]-florbetaben in the APPswe/PS1dE9 mouse model.
Novel Symmetrical 1,4-Disubstituted-bis-1,2,3-Triazoles: Synthesis by Double CuAAC and Cytotoxicity Evaluation
Authors: Reis Wallace J. , Moreira Paulo O.L. , Alves Rosemeire B. , Oliveira Heloísa H.M. , Silva Luciana M. , Varotti Fernando P. , Freitas Rossimiriam P. 
Published: October 2018

Background:
A series of symmetrical 1,4-disubstituted bis-1,2,3-triazoles was prepared by
double copper catalyzed Azide-alkyne Cycloaddition (CuAAC) from aliphatic bis-azides and a
tetraethylene glycol bis-azide derivative. The eighteen novel compounds were evaluated in vitro for their
cytotoxic activity against two human tumor cell lines: Human breast adenocarcinoma (MDA-MB 231)
and ovarian adenocarcinoma (TOV-21G).

Results and Conclusion:
The results of colorimetric MTT assays showed that compounds 4j and 4q
exhibited a better selectivity index and cell viability comparable with the standard drug doxorubicin.
These compounds induced apoptosis in both tested cell lines, as assessed by BrdU assay. The results
suggest that these structurally simple compounds may be promising prototypes for antitumoral agents.
Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)
Authors: Yilmaz Yildiz , Williams Gareth , Walles Markus , Manevski Nenad , Krähenbühl Stephan , Camenisch Gian 
Published: October 2018

<P>Background: Although the liver is the primary organ of drug metabolism, the lungs also contain drug-metabolizing enzymes and may, therefore, contribute to the elimination of drugs. In this investigation, the Precision-cut Lung Slice (PCLS) technique was standardized with the aims of characterizing and comparing rat and human pulmonary drug metabolizing activity. </P><P> Method: Due to the limited availability of human lung tissue, standardization of the PCLS method was performed with rat lung tissue. Pulmonary enzymatic activity was found to vary significantly with rat age and rat strain. The Dynamic Organ Culture (DOC) system was superior to well-plates for tissue incubations, while oxygen supply appeared to have a limited impact within the 4h incubation period used here. </P><P> Results: The metabolism of a range of phase I and phase II probe substrates was assessed in rat and human lung preparations. Cytochrome P450 (CYP) activity was relatively low in both species, whereas phase II activity appeared to be more significant.Conclusion:PCLS is a promising tool for the investigation of pulmonary drug metabolism. The data indicates that pulmonary CYP activity is relatively low and that there are significant differences in enzyme activity between rat and human lung.</P>
Tribulus terrestris in Management of Sexual Functions
Authors: Mahboubi Mohaddese 
Published: October 2018

Background:
Tribulus terrestris (Zygophyllaceae family) is believed to have aphrodisiac
activity in different cultures.

Objective:
The aim of this study was to evaluate the efficacy of T. terrestris in the management of
sexual functions in female and male patients.

Methods:
We searched in PubMed Central, Science Direct, Wiley, Springer, SID, accessible books,
reports, and thesis.

Results:
According to the results of animal and human studies, standard T. terrestris improved erectile
parameters. After administration of T. terrestris, an increase in testosterone level was observed
in most animal studies, while this increase was not confirmed in male human studies. T. terrestris
improved the sperm parameters in animal and human studies. T. terrestris enhanced the folliculogenesis
and improved polycystic ovary syndrome (PCO) in animal studies. The human clinical studies
confirmed its efficacy on female sexual disorders.

Conclusion:
Therefore, standard T. terrestris extract as a valuable herbal compound can be considered
an improvement of sexual functions in both sexes.
An Automated Technique for Optic Disc Detection in Retinal Fundus Images Using Elephant Herding Optimization Algorithm
Authors: Pruthi Jyotika , Arora Shaveta , Khanna Kavita 
Published: October 2018

Background:
Glaucoma and diabetic retinopathy are known to be the prime reasons for
causing irrevocable blindness in the world. However, the complete vision loss can be obstructed
through regular screening of the eye to detect the disorder at an early stage.

Objective:
In this paper, we have presented a novel nonlinear optimization technique that helps in
automatic detection of the optic disc boundary from retinal fundus images thereby satisfying the anatomical
constraints by using elephant herding optimization algorithm.

Methods:
In our approach, median filter has been used for the noise removal in retinal images. The
pre-processed image is passed to the metaheuristic algorithm known as Elephant Herding Optimization
algorithm.

Results:
The proposed technique for optic disc segmentation has been applied and tested on four
standard publicly available datasets namely DRIVE, DIARETDB1, STARE and DRIONS-DB. The
ground truth of the optic disc boundary has been collected from two experts of glaucoma: Expert A
and Expert B who are specialists of glaucoma. The quantitative and qualitative analysis has been
done to evaluate the performance of optic disc segmentation techniques.

Conclusion:
The proposed technique for optic disc detection helps to obtain the smooth boundaries
in retinal fundus images. The aim has been successfully achieved by proposing an approach using
EHO to achieve optimized solution. The effectiveness of the approach has been evaluated on for
benchmark datasets and the acquired results have shown the accuracy values to be 100% for DRIVE,
100% for DIARETDB1, 99.25% for STARE and 99.99% for DRIONS-DB.
RELAÇÃO INTERTEXTUAL ENTRE SLOGANS E PRODUÇÃO CIENTÍFICA NO CAMPO DO HIV/AIDS
Authors: Suto Cleuma Sueli Santos , Vaz Sampaio Santos Milena , Santana Rios Paula Patrícia , Santos Paiva Mirian 
Published: October 2018

As peças publicitárias de campanhas midiáticas relacionadas à prevenção foram utilizadas como produção textual e se configuraram como ferramenta-chave na construção das representações sociais. O objetivo da pesquisa foi analisar a relação intertextual entre as publicações científicas sobre cuidado às pessoas com Vírus da Imunodeficiência Humana/Síndrome da Imunodeficiência Adquirida, no período de 10 anos (2002-2011), e as campanhas midiáticas para o Dia Mundial de Luta Contra a Síndrome da Imunodeficiência Adquirida, nesse mesmo período. Trata-se de uma pesquisa documental e descritiva em bases de dados e em documentação oficial. Os resultados permitiram perceber a existência de quatro categorias: gênero, geração, preconceito/discriminação e raça, sendo que houve predomínio no foco das campanhas para o tema preconceito, demonstrando intenção governamental em interferir na representação social negativa, discriminatória e historicamente associada à Síndrome da Imunodeficiência Adquirida. A intertextualidade na categoria gênero identificou conteúdos que destacam o protagonismo feminino na prevenção/tratamento ou no estabelecimento das estratégias de enfrentamento. E, na categoria geração, independente do pertencimento geracional, a experiência com o Vírus da Imunodeficiência Humana/Síndrome da Imunodeficiência Adquirida é difícil, complexa e limitante. Concluiu-se que a relação intertextual apresenta-se como forma de apreender a dinâmica dessa epidemia e pode trazer contribuição à forma de agir frente às suas diversas facetas. A intertextualidade constitui-se em um recurso eficaz para apreender a construção do sentido, conferindo-lhe coerência e credibilidade. Utilizá-la com propriedade, como apoio argumentativo ou simplesmente como um jogo linguístico, contribui para a compreensão das representações sociais sobre a Síndrome da Imunodeficiência Adquirida ao longo da epidemia.
Palavras-chave: Síndrome de Imunodeficiência Adquirida. Vírus da Imunodeficiência Humana. Publicidade como assunto.
DIFICULDADES E FACILIDADES NO PROCESSO DE PLANEJAMENTO EM SAÚDE NA ESTRATÉGIA DE SAÚDE DA FAMÍLIA
Authors: Dos Santos Sueli Vieira , Casotti Cezar Augusto , Alves Vilela Alba Benemérita , Sales Vieira Sheylla Nayara , Nery Adriana Alves 
Published: October 2018

A Estratégia Saúde da Família destaca-se como uma das estratégias resultantes do planejamento municipal efetivo, criada para operacionalizar a nova maneira de gerir a saúde para garantir a assistência à saúde. A pesquisa objetivou identificar as dificuldades e facilidades que as equipes da Estratégia Saúde da Família encontram no processo de planejamento em saúde. Trata-se de um estudo de caso, descritivo, de abordagem qualitativa, realizado com 30 profissionais que atuam nas Estratégias Saúde da Família do município, por meio de entrevista semiestruturada e observação sistemática. Para análise dos dados, optou-se pela técnica do Discurso do Sujeito Coletivo, com o auxílio do software Quantiqualisoft. Os resultados apontaram cinco ideias centrais que geraram os respectivos discursos do sujeito coletivo: não participação de sujeitos estrategicamente importantes no planejamento em equipe; demandas que dificultam a execução do planejamento; conflito de interesses; planejar em equipe possibilita troca de conhecimento, facilita as decisões e proporciona melhores resultados; os sujeitos envolvidos no processo de planejamento são compromissados com o serviço. Concluiu-se que, no município analisado, os profissionais de saúde que atuam nas Estratégias Saúde da Família encontram dificuldades e facilidades no processo de planejamento das ações de saúde desenvolvidas pelas equipes.
Palavras-chave: Planejamento. Planejamento em saúde. Práticas de planejamento. Estratégia Saúde da Família.
IMPACTO DE UMA INTERVENÇÃO NUTRICIONAL NAS PRÁTICAS ALIMENTARES DE ESTUDANTES DE UMA ESCOLA PARTICULAR
Authors: Bezerra do Nascimento Kivia Kelly , Da Costa Silva Bruna Yhang 
Published: October 2018

Diversos hábitos alimentares de crianças e adolescentes podem influenciar na qualidade nutricional da dieta. O objetivo deste trabalho foi avaliar o impacto de uma intervenção nutricional nas práticas alimentares de estudantes de uma escola de Russas, Ceará, Brasil. Trata-se de estudo quantitativo, longitudinal, de intervenção nutricional, do tipo descritivo-analítico, realizado no período de outubro de 2013 a junho de 2014, em uma escola particular da cidade de Russas, utilizando uma amostra de 40 alunos, matriculados do 3º ao 8º ano. A pesquisa compreendeu três etapas: coleta de dados com aplicação de dois recordatórios alimentares de dias não consecutivos e questionário de práticas alimentares; uma intervenção nutricional; e uma nova coleta de dados pós-intervenção. Todos os dados colhidos foram incluídos em planilha de Excel e apresentados em frequências simples e percentual, média e variações. Os resultados mostraram, na pré-intervenção, consumo inadequado de nutrientes importantes como cálcio, fósforo, vitamina A, ácido ascórbico e fibras. O cálcio foi o mineral com predominância de possível baixo consumo (97,50%). Em relação à pós-intervenção, observou-se um aumento no percentual de estudantes cujo consumo dos nutrientes referidos estava possivelmente adequado. Concluiu-se que houve efetividade parcial das intervenções realizadas nesta pesquisa na modificação dos hábitos alimentares das crianças avaliadas de uma escola particular de Russas, uma vez que nem todos os achados podem ser considerados favoráveis, como, por exemplo, o aumento do consumo de refrigerantes.
Palavras-chave: Dieta. Comportamento alimentar. Estudantes.
HUBUNGAN PELAKSANAAN USAHA KESEHATAN SEKOLAH (UKS) DENGAN UPAYA PROMOSI KESEHATAN PADA SEKOLAH DASAR NEGERI DI SIDOARJO TAHUN 2016
Authors: Aslina Aslina , Soedirham Oedojo , Siswantara Pulung 
Published: October 2018

The realization of school health promotion campaign is Usaha Kesehatan Sekolah (UKS) which has three main programs: health education, health service and school health environment coaching, therefore UKS facilities will support the realization of PHBS in school. Oescribe the connection of UKS implementation with health promotion campaign in SDN Geluran 1 Taman and SDN Barengkrajan 2 Krian Sidoarjo Regency. Observational research on predisposing factor, enabling factor and reinforcing factor related to the behavior of UKS cadre on the effort to promote health in schools. Based on the observation, 34 of 38 UKS cadre are well educated (89,5%), so does the attitude, trust and assessment categories are good, it came to conclusion that the behavior of the cadre on both schools on the attempt to promote health are good. Based on the chi-square statistic result all categories included knowledge, attitude, trust and assessment of UKS cadre on the attempt to promote health in school scores p < 0.05, it means there is connection between UKS implementation with the attempt of health promotion in the elementary school. To support the UKS cadre activity in school, health trainings and counseling are periodically needed and the availability of proper tools and infrastructures of UKS activity.

ABSTRAK
Bentuk upaya promosi kesehatan di sekolah yaitu melalui Usaha Kesehatan Sekolah (UKS) yang mempunyai tiga program pokok UKS (TRIAS UKS) yaitu pendidikan kesehatan, pelayanan kesehatan dan pembinaan lingkungan sekolah sehat, dengan adanya fasilitas UKS akan sangat menunjang terwujudnya PHBS di sekolah. Tujuan: menjelaskan hubungan pelaksanaan UKS dengan upaya promosi kesehatan di SDN Geluran 1 Taman dan SDN Barengkrajan 2 Krian Kabupaten Sidoarjo. Penelitian observasional yang mengkaji faktor predisposisi (predisposing factor), faktor pendukung (enabling factor), faktor pendorong (reinforcing factor) yang di hubungkan dengan perilaku kader UKS dalam upaya promosi kesehatan di sekolah. Berdasarkan hasil observasi, kategori pengetahuan siswa baik dari 38 kader UKS, sebanyak 34 kader (89,5%) berpengetahuan baik, demikian juga dengan kategori sikap, kepercayaan dan kategori penilaian semuanya baik, dapat dikatakan bahwa perilaku kader UKS pada kedua sekolah dasar tersebut dalam pelaksanaan upaya promosi kesehatan sudah baik. Dari hasil uji statistik chi-square semua kategori pengetahuan, sikap, kepercayaan dan penilaian kader UKS dengan upaya promosi kesehatan didapat nilai p < 0,05 yang berari ada hubungan pelaksanaan UKS dengan upaya promosi kesehatan di Sekolah Dasar Negari tersebut. Guna menunjang kegiatan kader UKS pada sekolah dibutuhkan pelatihan atau penyuluhan pendidikan kesehatan yang dilakukan secara berkala kepada kader UKS dan tersedianya sarana dan prasarana yang memadai untuk kegiatan UKS.
Pengaruh Cara Pengolahan terhadapMutu Bakteriologis Ikan Tongkol (Euthynnus affinis) Pindang Siap Santap
Authors: Exsyupransia Mursyanti Ekawati Purwijantiningsih 
Published: October 2018

The objectiveof this present research was toknowthe influence ofvarious way ofcooking on bacteriologicalquality of ready-to-eat salted little tunafish (Euthynnusaffinis).Previousstudyhas shown thatbacteriological quality ofsaltedtunafishfrom markets in Yogyakarta were not fulfill the requirements based on SNI 01-2717-1992. It was shown that the aerobic plate countswere high, i.e.2.4 x 105– 5.27 x 107CFU/g. Coliformcountranged from < 2.5 x 101- > 6.5 x 106CFU/g.Fromthe20samples observed, only 1 sample did not contain V. parahaemolyticus and 4 samples were negative from Salmonella. Therefore,it needs to bestudied whether thevarious way ofcookingsuch asfrying, fryingwith flour, fryingwith egg and fryingwith chili sauce were effectivein removing any of the groups of bacteria examined from saltedlittle tuna fish sample. The bacterial groups examined as indicator of quality were Staphylococcus aureus, Coliform, Salmonellaand Vibrio parahaemolyticus. The aerobic plate counts were also taken. The result showed that the various way of cooking wereeffective in reducing the aerobic plate counts, S. aureusand Coliform. Frying with chili sauce was the best cookingprocedure because it can reduced the highest number of aerobic plate counts, S.aureusand Coliform. Salmonellaand V. parahaemolyticuswere not detected in all cooking samples.