bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arbeit, Tauschgerechtigkeit und gesundheitliche Ungleichheit
Authors: Siegrist Johannes 
Published: November 2018

ZusammenfassungSozial ungleich verteilte Arbeitsbelastungen tragen zu einer höheren Krankheitslast bei sozial benachteiligten Gruppen bei. Im Zuge wirtschaftlicher Globalisierung sind diese Gruppen zunehmend von Belastungen infolge verletzter Tauschgerechtigkeit betroffen. Internationale Forschungsergebnisse zu damit assoziierten stressbedingten Erkrankungsrisiken legen geziel-te verhältnispräventive Aktivitäten auf betrieblicher und überbetrieblicher Ebene nahe.
Obdachlosigkeit und Gesundheitsversorgung
Authors: Trabert Gerhard 
Published: November 2018

Zusammenfassung
Wohnungslosigkeit in Deutschland ist ein zunehmendes soziales Phänomen, insbesondere was die Anzahl betroffener Menschen und die Bedeutsamkeit für die Realisierung einer inklusiven Gesellschaft angeht. Seine Ausprägung ist sowohl psychosozial (mit-)verursacht als auch sozioökonomisch bedingt, oft mit sich negativ verstärkenden Wechselwirkungen. Eine Übersicht über die gesundheitlichen Auswirkungen wird gegeben, und konkrete Verbesserungsmöglichkeiten an Hand des Mainzer Modells und der Poliklinik ohne Grenzen, sogenannte niedrigschwellige Gesundheitsversorgungseinrichtungen, aufgezeigt. Eine flächendeckende Verfügbarkeit einer angemessenen medizinischen Versorgung ist individuelles Recht und soziale Pflicht für eine der Inklusion (selbst)verpflichteten Gesellschaft.
Krankheitstheorien und Versorgungserwartung von Patienten sichtbar machen
Authors: Pirnay-Dummer Pablo , Kampmann Inga 
Published: November 2018

Abstract
In this chapter, we present a new method for the medical field, which can contribute to patient-oriented care, especially in shared decision making. The mental models and conceptions of patients about their illness and the expected care determines their perception, decision and use of the care system - and thus they also influence the adherence. If the illness-health-model as part of the health literacy of the patients is known and recognized by the doctors throughout the decision-relevant processes, this facilitates a working patient-doctor relationship not only on a level of general kind communication. It helps doctors to better understand why patients decide in a certain way and why. By using the computer-linguistic methodology and software presented in this chapter, it is possible to automatically and objectively analyse, aggregate and cluster large data sets of written mental models and beliefs based on the patientsʼ models to create a comprehensive overview of common belief clusters. The results can be visualized on comprehensive knowledge maps and then used by the treating physicians. The knowledge maps are disease-specific and can - after a successful instruction and training - be used by physicians to improve the factual understanding of patient concerns.
Model Development for Computing Cracking in Soil Reinforced with Fibers from Three Different Bioresources
Authors: Gopal Phani , Bordoloi Sanandam , Cai Weiling , Liang Huasheng , Boddu Rishita , Sreedeep S. , Buragohain Poly , Garg Ankit 
Published: November 2018

Abstract
The study explores the effects of three different lignocellulose fiber-reinforced (jute, coir, and water hyacinth [WH]) soils on the desiccation potential of compacted clayey silt soil. A new model was developed using artificial neural networks (ANN) for estimating cracking in soil reinforced with different fibers as a function of suction and water content. The program for ANN was developed in house using C++. Before model development, suction and water content were simultaneously monitored for 105 days along with the crack intensity factor (CIF). After model development, relative significance of each parameter (suction and water content) on the corresponding CIF was estimated. Adding lignocellulose fibers significantly increased the water retention capacity in the soil and reduced the CIF significantly as compared to unreinforced soil (almost half the amount). Obtained ANN models were efficient in predicting the CIF. The CIF is inversely proportional to water content and directly proportional to suction. The CIF value in bare soil, jute, and WH composites primarily depends on suction. Because of the increased water retention capacity of coir, the value of CIF depends equally on both suction and water content values. The log normal distribution of CIF was found in soil–jute composites.
Parenting Stress and Hypertension in Parents of Mental Retardation Children
Authors: Kamerawati Choni , Prasetyowati Irma , Ariyanto Yunus 
Published: November 2018

Abstract

Parents with mental retardation children experience higher parenting stress than parents with other types of disability. Differences in responses to stressors indicate a level of parenting stress that is influenced by the characteristics of children, family, parents, and the environment. Parenting stress that is not managed and occurs in a long time can cause physical disorders of hypertension. The purpose of this study was to describe the parenting stress and the incidence of hypertension in the parents of children with mental retardation aged 12-15 years. This research is a descriptive research with quantitative approach. The sample of this study was the father and mother of mental retardation students aged 12-15 years of 59 respondents who met the criteria of inclusion and exclusion. The result of this research is most of the hypertension respondent have high parenting stress level of 53,6% in fathers and 64,5% in mothers.

Keywords: hypertension, mental retardation, parenting stress, parents.

Abstrak

Orang tua dengan anak retardasi mental cenderung mengalami parenting stress tinggi dibandingkan orang tua dengan anak jenis kecacatan lain. Adanya perbedaan tanggapan terhadap stressor menunjukkan adanya tingkatan parenting stress yang dipengaruhi oleh karakteristik anak, keluarga, orang tua, dan lingkungan. Parenting stress yang tidak dikelola dan tejadi dalam waktu lama terjadi dapat menyebabkan gangguan fisik hipertensi. Tujuan penelitian ini adalah menggambarkan parenting stress dan kejadian hipertensi pada orang tua yang mengasuh anak retardasi mental usia 12-15 tahun. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kuantitatif. Sampel penelitian ini adalah ayah dan ibu siswa retardasi mental usia 12 – 15 tahun sebesar 59 responden yang memenuhi kriteria inklusi dan eksklusi. Hasil dari penelitian ini adalah sebagian besar responden hipertensi mengalami tingkat parenting stress tinggi sebesar 53.6 % pada ayah dan 64.5 % pada ibu.
Kata kunci: hipertensi, orang tua, parenting Stress, retardasi mental.
An atypical case of pulmonary embolism from a jugular vein
Authors: Velcea A. E. , Baldea S. Mihaila , Muraru D. , Badano L. P. , Vinereanu D. 
Published: November 2018

Summary
Neck venous malformations and their potentially life-threatening complications are rarely reported in the available literature. Cases of aneurysmal or hypo-plastic jugular vein thrombosis associated with systemic embolization have not been frequently reported. We present the case of a 60-year-old male, without any known risk factors for thromboembolic disease, admitted for sudden onset dyspnea. The physical examination was remarkable for a right lateral cervical mass, expanding with Valsalva maneuver. Thoracic CT with contrast established the diagnosis of bilateral pulmonary embolism and raised the suspicion of superior vena cava and right atrial thrombosis. Bedside transthoracic echocardiography confirmed the presence of a large right atrial thrombus, with intermittent protrusion through the tricuspid valve. Systemic thrombolysis with Alteplase was initiated shortly after diagnosis, in parallel with unfractionated heparin, with complete resolution of the intracavitary thrombus documented by echocardiography. The patient showed significant improvement in symptoms and was later started on oral anticoagulation. Computed vascular tomography of the neck was performed before discharge, showing hypoplasia of the left internal jugular vein and aneurismal dilation of the contralateral internal jugular vein, without thrombosis. There were no identifiable systemic causes for thrombosis. Surgical resection of the aneurismal jugular vein was excluded, because of its potential to cause intracranial hypertension. The preferred therapeutic option in this case was long-term oral anticoagulation.
High Efficiency Targeting of Non-coding Sequences Using CRISPR/Cas9 System in Tilapia
Authors: Li Minghui , Liu Xingyong , Dai Shengfei , Xiao Hesheng , Wang Deshou 
Published: November 2018

Abstract
The CRISPR/Cas9 has been successfully applied for disruption of protein coding sequences in a variety of organisms. The majority of the animal genome is actually non-coding sequences, which are key regulators associated with various biological processes. In this study, to understand the biological significance of these sequences, we used one or dual gRNA guided Cas9 nuclease to achieve specific deletion of non-coding sequences including microRNA and 3′ untranslated region (UTR) in tilapia, which is an important fish for studying sex determination and evolution. Co-injection of fertilized eggs with single gRNA targeting seed region of miRNA and Cas9 mRNA resulted in indel mutations. Further, co-injection of fertilized eggs with dual gRNAs and Cas9 mRNA led to the removal of the fragment between the two target loci, yielding maximum efficiency of 11%. This highest genomic deletion efficiency was further improved up to 19% using short ssDNA as a donor. The deletions can be transmitted through the germline to the next generation at average efficiency of 8.7%. Cas9-vasa 3′-UTR was used to increase the efficiency of germline transmission of non-coding sequence deletion up to 14.9%. In addition, the 3′-UTR of the vasa gene was successfully deleted by dual gRNAs. Deletion of vasa 3′-UTR resulted in low expression level of vasa mRNA in the gonad when compared with the control. To summarize, the improved CRISPR/Cas9 system provided a powerful platform that can assist to easily generate desirable non-coding sequences mutants in non-model fish tilapia to discovery their functions.
King of the Birds! The changing role of white-tailed (Haliaeetus albicilla) and golden-eagles (Aquila chrysaetos) in Britain’s past
Authors: Holmes Matilda 
Published: November 2018

El trabajo valora restos de Águila Real y Pigargo de 58 yacimientos arqueológicos británicos que cubren desde el Mesolítico a época medieval desde la perspectiva de los variados y cambiantes roles de estos animales utilizando fuentes zooarqueológicas, contextuales, docu- mentarias y etnográficas. Se presenta evidencia que revela la cambiante importancia cultural y social de ambas aves. Ello incluye su explotación por parte de las poblaciones costeras como talismanes en la Edad del Bronce por sus plumas en la Edad del Hierro y romana y como an- imales de exhibición en las ferias medievales. Las relaciones entre las águilas y los humanos se valoran también sobre la base de percepciones recurrentes y duraderas a través de distintas culturas.
Building envelope and energy demand in retrofitting office
Authors: Darula S. , Malikova M. 
Published: November 2018

Building envelopes have a significant role in the protection of interiors against weather conditions. While wind, rain barriers and barriers against excessive heat gains were constructed from insufficient elements in the past, the current requirements for envelope functions are different. New materials and technologies allow for more complex design and evaluation of parameters in regard to the needs of occupants and economical interior performance.
This paper is focused on the daylighting solutions inside lit office space in which renovation of the lighting system is expected. Several retrofit scenarios based on window shading variations and lighting systems are investigated. Achieved results are evaluated from the point of view of energy demand. The integrative multi-platform tool, the Lighting Retrofit Adviser (LRA) is applied to calculate energy renovation preferences and to accept decision.
Estresse gravitacional no pós-operatório de cirurgia cardíaca
Authors: Viana Patrícia Alcântara Doval de Carvalho , Lordello Gleide Glícia Gama , Serra Juliana Martini Matos , Rosier Gabriela Lago , Correia Luís Cláudio 
Published: November 2018

INTRODUÇÃO: Após a cirurgia cardíaca, a mobilização precoce busca o ganho funcional e um melhor condicionamento para as próximas fases da reabilitação cardiovascular, tendo o estresse gravitacional(EG)um importante papel para o retorno destas atividades, através da integridade dos mecanismos compensatórios cardiovasculares. OBJETIVO: verificar o comportamento de variáveis circulatórias e respiratórias durante o EG no pós-operatório de cirurgia cardíaca. MÉTODOS E MATERIAIS: Estudo observacional, transversal e analítico, composto por 83 indivíduos adultos clinicamente estáveis, submetidos a cirurgia de revascularização do miocárdio ou abordagem valvar. Excluídos aqueles com dificuldade de compreensão das atividades realizadas, além de comprometimento motor e/ou neurológico que impossibilitassem a realização do EG, de forma adaptada. Foram coletados os dados circulatórios e respiratórios no 1° minuto para cada etapa através do monitor multiparamétrico Gemedical Systems@. RESULTADOS: As frequências cardíaca e respiratória apresentaram um aumento com significância estatística (p ? 0,01), quando analisado seus valores de variação de decúbito dorsal para sedestação e decúbito dorsal para ortostase. CONCLUSÃO: As variáveis hemodinâmicas e respiratórias se comportam de acordo com a resposta fisiológica durante o EG, sugerindo que esse procedimento é seguro no ambiente da terapia intensiva, mesmo se tratando de um pós-operatório de alta complexidade.
Fatores de risco cardiovascular associados à hipertensão arterial sistêmica em escolares
Authors: Soares Raoni , Tosta Larissa Santos , Cavalcante Luciana Ricarte , Zarife André Sant'Anna , Brito Luciara Leite , Fraga-Maia Helena 
Published: November 2018

INTRODUÇÃO: A análise conjunta dos hábitos de vida que podem predispor ao aparecimento de doenças cardiovasculares na idade adulta tem papel importante para o conhecimento do perfil de risco cardiovascular de crianças e adolescentes. OBJETIVO: Investigar hábitos alimentares inadequados e fatores de risco cardiovascular associados à Hipertensão Arterial Sistêmica em escolares de 7 a 14 anos de idade, domiciliados no Cabula/Beiru na cidade do Salvador, Bahia, Brasil. MÉTODOS: Estudo transversal com 162 escolares matriculados na rede pública do Ensino Fundamental I, residentes no Distrito Sanitário Cabula Beiru (DSCB), na cidade do Salvador, Bahia. Regressão logística multivariada, não-condicional, hierarquizada, foi usada para avaliar a associação, após ajustes por fatores sociodemográficos e de saúde, entre a HAS, hábitos alimentares inadequados e fatores de risco cardiovascular. RESULTADOS: A prevalência de hipertensão arterial entre os escolares foi estimada em 23,0% e o excesso de peso (OR=4,08; IC95% 1,75 – 9,55), assim como a inatividade física (< 300 min/semana) (OR=5,69; IC95% 1,56 – 20,69), consumo inadequado de doces (OR=2,65; IC95%: 1,01 – 7,00) e de refrigerantes (OR=3,61; IC95%: 1,28 – 10,13) foram os fatores associados com pressão arterial elevada. CONCLUSÕES: Os dados evidenciam hábitos inadequados de alimentação e fatores de risco cardiovasculares, em especial, sobrepeso ou obesidade e ser insuficientemente ativo. Estes resultados reforçam a necessidade de programas de promoção de saúde e prevenção dos riscos direcionados à parcela mais jovem da população. Recomendamos a adoção de estratégias para o controle do peso e estímulo à prática regular de atividade física nas escolas, bem como ações de educação em saúde no Ensino Fundamental.
Development and validation of aranosa assay in the dosage form
Authors: Shprakh Z. S. , Ignаteva E. V. , Yartseva I. V. 
Published: November 2018

Background. Aranosa, a drug of nitrosoalkylureas class, was developed and studied at N.N. Blokhin NMRCO, Russia, and at present it is produced by N.N. Blokhin NMRСO branch “Naukoprofi”. One of the stages of the drug standardization is the development of an assay technique for quantitative determination of active substance in the final drug dosage form.Objective. Development and validation of an assay for quantitative determination of Aranosa in the dosage form.Materials and methods. The study used “Aranosa, lyophilisate for solution for injection 0.5 g”; Аranosa, substance-powder (N.N. Blokhin NMRCO branch “Naukoprofi”); polyvinylpyrrolidone low-molecular medical; sorbic acid. Method: spectrophotometry. Results. An assay was developed for quantitative spectrophotometric determination of Aranosa in the dosage form “Aranosa, lyophilisate for solution for injection 0.5 g”. Validation was performed to prove reliability and accuracy of the obtained results. The assay was evaluated by validation characteristics, such as specificity, linearity, trueness, precision.Conclusions. The developed assay is provided with trueness, repeatability, precision, and linearity and can be used in the range of 80– 120 % of nominal Aranosa content in the dosage form.
Lymphocytes blast-transformation reaction: modification for allergological practice
Authors: Manina I. V. , Sergeev V. Yu. , Golubtsova N. V. , Sergeev A. Yu. 
Published: November 2018

Introduction. Lymphocytes blast-transformation reaction (RBLT) is necessary for patient’s inspection with immunologic infringements. It is applied in the different fields of medicine to identification of a sensitization to antigens (allergens).Research objective – to modify and automate RBTL for application in routine laboratory practice.Materials and methods. RBTL, antigens (allergens). Software: Windows 7; Intel Pentium G4500 CPU. Digital CMOS video camera, Mikmed-6 microscope.Results. We analyzed difficulties when using RBTL in laboratory allergological practice. We created program files for automation of RBTL.Conclusion. We adapted and automated RBTL for laboratory diagnostics using.
Expression of epithelial marker CK19 in mice with mammary adenocarcinoma afterexposure to fito-anti-estrogen secoisolariciresinol
Authors: Shubina I. Zh. , Treshalina E. M. , Kuznetsov S. A. , Smirnova G. B. , Borisova Yu. A. , Sitdikova S. M. , Sitdikova M. V. , Shprakh Z. S. 
Published: November 2018

Introduction.Phyto-anti-estrogen secoisolariciresinol (SECO) has similar effectiveness to that of Tamoxifen (TAM), a member of selection estrogen receptor modulators, in estrogen-positive models of murine mammary adenocarcinoma and human breast cancer in vivo. Due to its antagonistic and agonistic functions Tamoxifen may enhance risk of development of uterine adenocarcinoma while providing effective prophylactics of breast cancer metastases. SECO effect on proliferative activity of circulating or disseminating tumor cells (occult metastases) is still unclear. We used epithelial cell marker – intracellular cytokeratin 19 (CK19) to study SECO function in terms of possible metastatic process, since prognostic significance of CK19 is well established for identifying occult metastases and breast cancer dissemination.Objective.To evaluate risk of tumor cell dissemination in mice with transplanted mammary adenocarcinoma after exposure to SECO and TAM.Materials and methods.Mice BDF 1 [C57Bl6j × DBA2] bearing Са755 of the 3rd passage were used for the experiments. CK19 expression was evaluated 24 hours after 10-day course of SECO in the effective single doses of 250 mg/kg or ТАM 50 mg/kg. Flow cytometry, immunofluorescence with light and luminescence microscopy were performed to evaluate CK19 expression.Results.Parameter GMFI ± SD (geometric mean fluorescence intensity ± SD) for CK19 expression in SECO and TAM groups in blood accounted for 28.87 ± 13.70 and 28.02 ± 9.50 and in control tumor growth (CTG) group GMFI ± SD was 31.94 ± 5.02; while in bone marrow it was 30.14 ± 2.33, 39.07 ± 2.30 and 32.48 ± 3.75, respectively.Conclusion.The results of the study showed similar expression of epithelial intracellular marker CK19 in blood in the studied groups of mice bearing mammary adenocarcinoma Ca755 sensitive to SECO and TAM exposure. GMFI for CK19 expression in bone marrow was lower in SECO group than in TAM (р = 0.0003). The data obtained in the murine model demonstrated no enhanced risk of tumor cell dissemination while performing treatment by phyto-anti-estrogen SECO in therapeutic regimen.
The influence of the drug LHS-1208 on cardiovascular system
Authors: Ermakova N. P. , Merkulova I. V. , Konyaeva O. I. , Kulbachevskaya N. Yu. , Abramova T. V. , Chaley V. A. , Nikolina A. A. , Bukhman V. M. 
Published: November 2018

Introduction.This article presents a fragment of a preclinical toxicological study of a new Russian anticancer drug derived from n-glycoside indolokarbazole LCS-1208 – study of cardiotoxicity, which is one of the specific complications of anticancer chemotherapy.Objective.Preclinical toxicological study of the effect of the drug LCS-1208 on the cardiovascular system of animals to assess its cardiotoxic effects.Materials and methods.Studies were conducted on 40 healthy non-harmless mongrel male rats and 4 dogs Beagle, male and female. The drug was administered daily 15 times to rats-intraperitoneal in total doses of 50, 100 and 200 mg/kg; to dogs – intravenously in total doses of 20 and 30 mg/kg. The period of observation of rats was 30 days, for dogs was 60 days. Changes in electrocardiogram indices, macroscopic and histological picture of heart changes and changes in biochemical parameters of enzymes activity – lactate dehydrogenase and aspartate aminotransferase were evaluated.Results.In rats LCS-1208 throughout the period of observation caused functional changes in electrocardiogram: increase in PQ and QT intervals and cardiac rhythm disturbance (loss of R wave), which indicates a violation of electrical conductivity. Morphological changes in the heart muscle were detected on the 3rd day of observation in total doses of 100 and 200 mg/kg, which remained until 30 days of observation only in animals receiving the drug in the total dose of 200 mg/kg. In some dogs for different periods of observation the drug caused functional changes in the electrical activity of the heart: an increase in the QRS interval, the inversion of the T wave, the appearance of a deep Q wave and an increase in the activity of lactate dehydrogenase and aspartate aminotransferase compared to back ground indicators. Morphological changes in the heart muscle were detected on the 3rd day of observation only in the total dose of 30 mg/kg, which persisted up to 60 days of observation.Conclusion.It was found that the new Russian anticancer drug LHC-1208, a derivative of indocarbazole N-glycoside, has a cardiotoxic effect, causing functional changes in the cardiovascular system of rats in all doses studied, and in dogs only in the maximum dose. Morphologically, cardiotoxicity is not confirmed in animals receiving a minimal dose of the drug, but only in animals receiving the maximum dose of the drug.