bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital medicine program with pediatric solid organ transplant patients: Perceived benefits and challenges
Authors: Triplett Kelli N. , El‐Behadli Ana F. , Masood Saba S. , Sullivan Sarah , Desai Dev M. 
Published: July 2019

AbstractGiven the complexity of the pediatric post‐transplant medication regimen and known medication adherence difficulties within the solid organ transplant population, interventions to improve adherence continue to be explored and fine‐tuned. Advances in technology have led to the development of new programs aimed at improving medication adherence and the overall care of transplant patients. This manuscript describes implementation of a DMP where transplant patients' medications were co‐encapsulated with ingestible sensors, and adherence was monitored via a patient mobile application and a provider portal. The benefits and challenges of the DMP as reported by patients, caregivers, and medical providers are explored in this manuscript. Participant feedback regarding best practices highlighted these benefits: ease of use/intuitive technology, sense of improved communication with medical team, increased knowledge and motivation around treatment regimen, and positive self‐reports of medication adherence. Challenges included reluctance to participate (n = 43, 54.43% of patients approached declined participation) and patch wearability difficulties reported by participants (n = 20; 68.97%). Other notable challenges included the following: limited drug profile compatibility with the DMP technology and concerns about privacy and electronic data sharing for patients who chose not to participate. DMP implementation highlighted how technological advances offer novel methods to assess adherence, enhance medical decision‐making, and can potentially improve clinical outcomes. Although numerous benefits of the program were recognized by participants, challenges were identified and the DMP technology and medication panel continues to be refined; further investigation of such programs continues to be warranted.
Behavioral insurance and economic theory: A literature review
Authors: Harrison Glenn W. , Ng Jia Min 
Published: July 2019

AbstractDecisions to purchase insurance should be a perfect place to see economic theory at work in general, and behavioral economics at work in particular. We have well‐developed theories of the demand for, and welfare evaluation of, insurance products. These theories extend relatively easily to the insights of behavioral economics. Unfortunately, the empirical literature has not maintained this tight connection. In fact, much of the empirical literature illustrates the dangers of the modern passion with agnostic economics: avoiding theory at all costs to focus on “what works.” We identify these dangers and the implications in the literature.
“Such Hatred Has Never Flourished on Our Soil”: The Politics of Holocaust Memory in Turkey and Spain
Authors: Karakaya Yağmur , Baer Alejandro 
Published: July 2019

AbstractIn this article, we analyze local Holocaust Remembrance Day (HRD) ceremonies promoted by the International Holocaust Remembrance Alliance (IHRA) in Spain and Turkey. We investigate whether these memory practices have the potential to lead to a cosmopolitan engagement with the host countries’ own pasts. Focused on the same memorial events in highly contrasting and diverse national contexts, this article examines how supranational memory discourses are adopted and reinterpreted within the nation‐state framework. Our ethnographic observation of the commemorations and analysis of the speeches between 2011 and 2018 in Turkey and 2005 and 2018 in Spain show that the Spanish ceremony can be defined as porous and to a certain degree open to multivocality—given the participation of different mnemonic communities—while the Turkish one is sealed and does not allow for the possibility of disrupting its self‐congratulatory national memory narrative. Paradoxically, in both cases, especially in Turkey, the national legitimation profiles are bolstered by the universal frameworks that Holocaust memory provides. Even though memory travels transnationally, the nation‐state still is the most powerful translator of this past. This results in the rendition of pre‐Holocaust nostalgic pasts as a multicultural heaven where different groups, including the Jewish community, lived in harmony.
Fast and low‐cost direct ELISA for high‐throughput serological HPA‐1a typing
Authors: Winkelhorst Dian , Porcelijn Leendert , Muizelaar Eva , Oldert Gonda , Huiskes Elly , van der Schoot C. Ellen 
Published: July 2019

BACKGROUNDFetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal alloantibodies against fetal human platelet antigens (HPAs), mostly caused by anti‐HPA‐1a. Population‐based screening for FNAIT is still a topic of debate. Logistically and financially, the major challenge for implementation is the typing of pregnant women to recognize the 2% HPA‐1a‐negative women. Therefore, there is need for a high‐throughput and low‐cost HPA‐1a‐typing assay.STUDY DESIGN AND METHODSA sandwich ELISA was developed, using a monoclonal anti‐GPIIIa as coating antibody and horseradish‐peroxidase‐conjugated recombinant anti‐HPA‐1a, as detecting antibody. The ELISA results were compared to an allelic discrimination PCR‐assay. In phase I, samples from unselected consecutive pregnant women were tested with both assays. Phase II was part of a prospective screening study in pregnancy and genotyping was restricted to samples with an arbitrary set, OD < 0.500.RESULTSThe ELISA was optimized to require no additional handling (swirling or spinning) of stored tubes. During phase I, 506 samples were tested. In phase II, another 62,171 consecutive samples were phenotyped, with supportive genotyping in 1,902. In total 1,585 HPA‐1a negative and 823 HPA‐1a positive women were genotyped. The assay reached 100% sensitivity with a cut‐off OD from 0.160, corresponding with a 99.9% specificity and a false‐HPA‐1a negative rate of 0.03.CONCLUSIONA high‐throughput, low‐cost, and reliable HPA‐1a phenotyping assay was developed which can be used in population‐based screening to select samples for testing of presence of anti‐HPA‐1a. Because plasma from tubes of 3‐ to 6‐days‐old samples can be used, this assay is applicable to settings with suboptimal conditions.
A comparative ultrastructural study of the pecten oculi in adult, juvenile, and nestling yellow‐legged gulls, Larus michahellis (Naumann, 1840)
Authors: Segovia Yolanda , Victory Noemí , Navarro‐Sempere Alicia , Pinilla Vanessa , García Magdalena 
Published: July 2019

AbstractThis study aimed at examining the histological structure of the pecten oculi in the adult yellow‐legged gull, Larus michahellis, and at two moments of postnatal development: during the posthatch (nestling) and juvenile periods. Particular attention was paid to differences in the diameter of vessels, the thickness of the basement membrane, and ultrastructural features of endothelial and pigmented stromal cells. Capillary endothelial cells displayed numerous microvillous‐like folds projecting from their internal and external surfaces. Intercellular spaces between capillaries were occupied by pigmented stromal cells. The ultrastructure of pecten oculi underwent noticeable changes during postnatal development. The examination of the capillaries in nestlings, juveniles, and adults revealed that the formation process of vessels and pigmented stromal cells did not complete itself in the posthaching phase. The prominent feature of endothelial cells of capillaries in nestlings was that the microvilli were longer than in juvenile and adult cells, and the capillary lumen was therefore reduced. In this sense, their pigmented stromal cells showed fewer melanosomes, lacked intercellular spaces, and cellular junctions could still be observed. These results provide evidence that the pecten oculi during the posthatching phase maintains immature morphological features consistent with a role of pigmented stromal cells in the blood‐retina barrier.
Outcome of phacoemulsification in 71 cats: A multicenter retrospective study (2006‐2017)
Authors: Fenollosa‐Romero Elena , Jeanes Emily , Freitas Ines , Enache Andra‐Elena , Lockhart Rachel , Fleming Lorraine , Knott Timothy N. L. , Dawson Charlotte , Smith Kerry , Busse Claudia 
Published: July 2019

AbstractPurposeTo assess outcome of phacoemulsification in cats.MethodsRecords of 71 cats (82 eyes) from five referral centers were reviewed. Groups were divided by cause of cataract (congenital/juvenile [n = 32], traumatic [n = 33], and secondary to uveitis [n = 6]), and group comparisons were performed for the most common complications: postoperative ocular hypertension (POH), uveitis, corneal ulceration, synechia/dyscoria, and posterior capsular opacity (PCO) in three different time periods: immediately postoperatively, at 1‐90 days, and at >90 days.ResultsMedian follow‐up was 198 days (interquartile range 64‐518 days). The overall visual success rate of the cats with a 12‐month follow‐up was 92.6% (25/27 eyes). POH occurred in 35/82 (42.6%) eyes. Immediately postoperatively, uveitis was the most common complication in 28/82 eyes (34.1%) followed by corneal ulceration in 22/82 eyes (26.8%). At 1‐90 days, uveitis in 41/81 eyes (50.6%) remained the most common complication, followed by synechia/dyscoria in 21/81 eyes (25.9%), corneal ulceration in 16/81 eyes (19.7%), and PCO in 15/81 eyes (18.5%). At >90 days, PCO in 17/47 eyes (36.1%), followed by synechia/dyscoria in 16/47 eyes (34%), was the most common complications. The number of eyes with synechia/dyscoria in the trauma group was higher (13/33 [39.3%]) than in the congenital/juvenile group (5/31 [16.1%]) at 1‐90 days (P = .039). No statistical difference was found for the other group comparisons. Three eyes in total were enucleated owing to endophthalmitis, post‐traumatic ocular sarcoma, and secondary glaucoma.ConclusionUveitis in the short‐term and PCO and synechia/dyscoria in the long‐term were the most common complications following phacoemulsification in cats.
Type 2 diabetes causes skeletal muscle atrophy but does not impair resistance training‐mediated myonuclear accretion and muscle mass gain in rats
Authors: Ato Satoru , Kido Kohei , Sato Koji , Fujita Satoshi 
Published: July 2019

New Findings
What is the central question of this study?
Type 2 diabetes mellitus (T2DM) causes skeletal muscle atrophy; does it affect resistance training (RT)‐mediated molecular adaptations and subsequent muscle hypertrophy?

What is the main finding and its importance?
Although skeletal muscle mass and regulation were not preserved under conditions of T2DM, the response of RT‐induced skeletal muscle hypertrophy was not impaired in T2DM rat skeletal muscle. These findings suggest that the capacity of RT‐mediated muscle mass gain is not diminished in the T2DM condition.

AbstractType 2 diabetes mellitus (T2DM) is known to cause skeletal muscle atrophy. However, it is not known whether T2DM affects resistance training (RT)‐mediated molecular adaptations and subsequent muscle hypertrophy. Therefore, we investigated the effect of T2DM on response of skeletal muscle hypertrophy to chronic RT using a rat resistance exercise mimetic model. T2DM and healthy control rats were subjected to 18 bouts (3 times per week) of chronic RT on unilateral lower legs. RT significantly increased gastrocnemius muscle mass and myonuclei in both T2DM and healthy control rats to the same extent, even though T2DM caused muscle atrophy in the resting condition. Further, T2DM significantly reduced mechanistic target of rapamycin complex 1 (mTORC1) activity (phosphorylation of p70S6KThr389 and 4E‐BP1Thr37/46) to insulin stimulation and the number of myonuclei in the untrained basal condition, but RT‐mediated adaptations were not affected by T2DM. These findings suggested that although the skeletal muscle mass and regulation were not preserved under basal conditions of T2DM, the response of RT‐induced skeletal muscle hypertrophy was not impaired in T2DM rat skeletal muscle.
Adaptive Finite Time Path-Following Control of Underactuated Surface Vehicle With Collision Avoidance
Authors: Ghommam Jawhar , Iftekhar Lamia , Saad Maarouf 
Published: July 2019

Abstract
This paper considers the finite time path-following control problem for an underactuated surface vessel subject to parametric uncertainties, unknown disturbances, and involving input-control saturation. A finite time command filtered backstepping approach is adopted as the main control framework along with the first-order sliding mode differentiator introduced to compute the derivatives of virtual control laws, and the analytical computational burden in the backstepping control is reduced for the design of the control for the underactuated surface vessel. A rigorous proof of the finite time stability of the closed-loop system is derived by utilizing the Lyapunov method. Furthermore, in order to avoid obstacles, a local path replanning technique is designed based on a repulsive potential function that acts directly on the original desired path. The effectiveness of the proposed strategy is validated through numerical simulations.
Variable Speed Control Moment Gyroscope in an Inverted Pendulum
Authors: Trentin João F. S. , da Silva Samuel , Schaub Hanspeter 
Published: July 2019

AbstractThe use of variable speed control moment gyroscope (VSCMG) is an effective way for attitude stabilization of aerospace devices. It is possible to control the oscillation and direction rate of change in rigid bodies in space due to the controlled change of angular momentum rate. Thus, this paper proposes an atypical pendulum configuration controlled by a VSCMG actuator. The idea of the VSCMG pendulum (VSCMGP) is to use both the angular momentum variation in amplitude and direction to implement the control. The controller is designed using Lyapunov theory to stabilize the pendulum in the inverted position. The results illustrate the control using a VSCMG in an inverted pendulum showing how the stabilization of an inverted pendulum is performed using two control actions. Also, the comparison of the proposed pendulum with a classical configuration is presented.
Control of Spatial Wave Profiles in Finite Lattices of Repelling Magnets
Authors: Al Ba'ba'a H. , Nouh M. 
Published: July 2019

Abstract
We report on the control of the spatial wave profile of a chain of lumped magnets arranged in a repelling configuration. The spatial wave attributes are controlled by varying the spacing between the magnets, which in turn affects the equivalent stiffness of the lattice. The dispersion relation for an infinite lattice is first derived for linearized equations of motion to provide an insight into the effect of varying the lattice spacing on the wavelength and sonic speed. The unit cell analysis is verified using analytical spatial wave profiles for a finite magnetic lattice. We conclude the paper with an analytical derivation of a fuel/time optimal controller designed to control the spacing between the magnets, which is necessary for implementation aspects.
Phase Separation in Vertical Header of Microchannel Condensers—A Mechanistic Model
Authors: Li Jun , Hrnjak Pega 
Published: July 2019

Abstract
Phase separation has been proven to increase performance of condensers of energy conversion systems (in vapor compression systems). Instead of conventional design, the inlet to a microchannel condenser prototype is in the middle of the height. After the first pass, in the vertical second header of the condenser, vapor phase separates from liquid phase due to gravity, and sometimes other effects. In ideal case vapor should go to the top and liquid to the bottom, resulting in increased heat transfer. Due to interaction between vapor and liquid, separation is not perfect, expressed through the separation efficiency. A mechanistic model presented in the paper is built to predict the phase separation efficiency based on force balance analysis for the liquid phase and correlations for the two-phase pressure drop. For the force balance criteria, liquid phase is divided into droplets and film and treated separately. Initial agreement with experiment is achieved to be within ±15%. For a second header at one inlet condition of the flow, the liquid separation efficiency is a function of the vapor separation efficiency. Liquid separation efficiency decreases with increasing inlet mass flux.
First-Order Eigen-Perturbation Techniques for Real-Time Damage Detection of Vibrating Systems: Theory and Applications
Authors: Bhowmik Basuraj , Tripura Tapas , Hazra Budhaditya , Pakrashi Vikram 
Published: July 2019

AbstractThis manuscript provides a detailed synopsis of the contemporary advancements in the nascent area of real-time structural damage detection for vibrating systems. The paper mainly focuses on the theoretical development and engineering applications of algorithms that are based on first-order perturbation (FOP) techniques applied to vibration responses. The importance of this work stems from the fact that recent developments in the field of online structural health monitoring (SHM) have given rise to algorithms that are computationally complex and, consequently, are not amenable to real-time implementation. In this paper, we discuss and demonstrate the FOP-based algorithms in the light of all the contemporary nonadaptive/nonrecursive techniques to establish their relevance. We review 216 papers in this regard. The efficacy, efficiency, robustness, and the applicability of the FOP family of algorithms are highlighted in light of several experimental, theoretical, and field studies.
Dynamic Characteristics of Motorized Spindle With Tandem Duplex Angular Contact Ball Bearings
Authors: Lin Shengye , Jiang Shuyun 
Published: July 2019

AbstractThe purpose of this study is to investigate the dynamics of motorized spindle, in which the tilting effect of tandem duplex angular contact ball bearing is considered. First, the quasi-static model of the duplex angular contact ball bearing is developed based on the Jones's bearing model. Then, the model is numerically solved using the Newton–Raphson method to obtain 16 stiffness coefficients (including the tilting ones). Later, a modified transfer matrix method is used to establish the dynamic model of the motorized spindle system with 16 stiffness coefficients. Finally, experiments have been performed to detect the stiffness of the tandem duplex angular contact ball bearing and the unbalance response of the motorized spindle. Results show that the modified transfer matrix method can be used to analyze the dynamic behavior of the motorized spindle supported on tandem duplex angular contact ball bearings, the tilting effect of the tandem duplex angular contact ball bearing affects the dynamic behaviors of the motorized spindle, and the theoretical dynamic characteristics using the proposed model agree with the experimental ones.
Fluid-Elastic Lock-in of a Cavity Shear Layer Instability With the Modes of a Submerged Cantilevered Beam
Authors: Cody Kristin L. , Jonson Michael L. , Pollack Martin L. , Hambric Stephen A. 
Published: July 2019

AbstractLock-in flow tones can occur for many different types of flow instabilities and structural-acoustic resonators at low Mach number. This paper examines the interaction between a shear layer instability generated by flow over a shallow cavity and the modes of an elastic cantilevered beam containing the cavity. A describing function model indicates that a cavity shear layer instability capable of producing lock-in with acoustic pipe resonances cannot achieve lock-in with equivalent structural beam resonances, particularly resonances of submerged structures. Fluid-elastic cavity lock-in is unlikely to occur due to the high level of damping that exists for a submerged structure, the high fluid-loaded modal mass, and the relatively weak source strength a cavity generates. Limited experimentation using pressure, acceleration, and particle image velocimetry (PIV) measurements has been performed which are consistent with the describing function model. A stronger source produced by a larger scale flow instability—separated flow over a bluff body—was able to lock-in with modes of the same submerged structure, further demonstrating that the concern for lock-in from a cavity shear layer instability is isolated to systems capable of stronger coupling or those dominated by fluid-acoustic resonances.
Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study
Authors: van Baar Annieke C G , Holleman Frits , Crenier Laurent , Haidry Rehan , Magee Cormac , Hopkins David , Rodriguez Grunert Leonardo , Galvao Neto Manoel , Vignolo Paulina , Hayee Bu’Hussain , Mertens Ann , Bisschops Raf , Tijssen Jan , Nieuwdorp Max , Guidone Caterina , Costamagna Guido , Devière Jacques , Bergman Jacques J G H M 
Published: July 2019

BackgroundThe duodenum has become a metabolic treatment target through bariatric surgery learnings and the specific observation that bypassing, excluding or altering duodenal nutrient exposure elicits favourable metabolic changes. Duodenal mucosal resurfacing (DMR) is a novel endoscopic procedure that has been shown to improve glycaemic control in people with type 2 diabetes mellitus (T2D) irrespective of body mass index (BMI) changes. DMR involves catheter-based circumferential mucosal lifting followed by hydrothermal ablation of duodenal mucosa. This multicentre study evaluates safety and feasibility of DMR and its effect on glycaemia at 24 weeks and 12 months.MethodsInternational multicentre, open-label study. Patients (BMI 24–40) with T2D (HbA1c 59–86 mmol/mol (7.5%–10.0%)) on stable oral glucose-lowering medication underwent DMR. Glucose-lowering medication was kept stable for at least 24 weeks post DMR. During follow-up, HbA1c, fasting plasma glucose (FPG), weight, hepatic transaminases, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), adverse events (AEs) and treatment satisfaction were determined and analysed using repeated measures analysis of variance with Bonferroni correction.ResultsForty-six patients were included of whom 37 (80%) underwent complete DMR and 36 were finally analysed; in remaining patients, mainly technical issues were observed. Twenty-four patients had at least one AE (52%) related to DMR. Of these, 81% were mild. One SAE and no unanticipated AEs were reported. Twenty-four weeks post DMR (n=36), HbA1c (−10±2 mmol/mol (−0.9%±0.2%), p<0.001), FPG (−1.7±0.5 mmol/L, p<0.001) and HOMA-IR improved (−2.9±1.1, p<0.001), weight was modestly reduced (−2.5±0.6 kg, p<0.001) and hepatic transaminase levels decreased. Effects were sustained at 12 months. Change in HbA1c did not correlate with modest weight loss. Diabetes treatment satisfaction scores improved significantly.ConclusionsIn this multicentre study, DMR was found to be a feasible and safe endoscopic procedure that elicited durable glycaemic improvement in suboptimally controlled T2D patients using oral glucose-lowering medication irrespective of weight loss. Effects on the liver are examined further.Trial registration numberNCT02413567