bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrafast structural rearrangement dynamics induced by the photodetachment of phenoxide in aqueous solution
Authors: Debnath Tushar , Mohd Yusof Muhammad Shafiq Bin , Low Pei Jiang , Loh Zhi-Heng 
Published: July 2019

AbstractThe elementary processes that accompany the interaction of ionizing radiation with biologically relevant molecules are of fundamental importance. However, the ultrafast structural rearrangement dynamics induced by the ionization of biomolecules in aqueous solution remain hitherto unknown. Here, we employ femtosecond optical pump-probe spectroscopy to elucidate the vibrational wave packet dynamics that follow the photodetachment of phenoxide, a structural mimic of tyrosine, in aqueous solution. Photodetachment of phenoxide leads to wave packet dynamics of the phenoxyl radical along 12 different vibrational modes. Eight of the modes are totally symmetric and support structural rearrangement upon electron ejection. Comparison to a previous photodetachment study of phenoxide in the gas phase reveals the important role played by the solvent environment in driving ultrafast structural reorganization induced by ionizing radiation. This work provides insight into the ultrafast molecular dynamics that follow the interaction of ionizing radiation with molecules in aqueous solution.
Ordering, flexibility and frustration in arrays of porphyrin nanorings
Authors: Summerfield Alex , Baldoni Matteo , Kondratuk Dmitry V. , Anderson Harry L. , Whitelam Stephen , Garrahan Juan P. , Besley Elena , Beton Peter H. 
Published: July 2019

AbstractThe regular packing of atoms, molecules and nanoparticles provides the basis for the understanding of structural order within condensed phases of matter. Typically the constituent particles are considered to be rigid with a fixed shape. Here we show, through a combined experimental and numerical study of the adsorption of cyclic porphyrin polymers, nanorings, on a graphite surface, that flexible molecules can exhibit a rich and complex packing behaviour. Depending on the number of porphyrin sub-units within the nanoring we observe either a highly ordered hexagonal phase or frustrated packing driven by directional interactions which for some arrangements is combined with the internal deformation of the cyclic polymer. Frustration and deformation occur in arrays of polymers with ten sub-units since close packing and co-alignment of neighbouring groups cannot be simultaneously realised for nanorings with this internal symmetry.
Analogue of dynamic Hall effect in cavity magnon polariton system and coherently controlled logic device
Authors: Rao J. W. , Kaur S. , Yao B. M. , Edwards E. R. J. , Zhao Y. T. , Fan Xiaolong , Xue Desheng , Silva T. J. , Gui Y. S. , Hu C.-M. 
Published: July 2019

AbstractCavity magnon polaritons are mixed quasiparticles that arise from the strong coupling between cavity photons and quantized magnons. Combining high-speed photons with long-coherence-time magnons, such polaritons promise to be a potential candidate for quantum information processing. For harnessing coherent information contained in spatially distributed polariton states, it is highly desirable to manipulate cavity magnon polaritons in a two-dimensional system. Here, we demonstrate that tunable cavity magnon polariton transport can be achieved by strongly coupling magnons to microwave photons in a cross-cavity. An analog to the dynamic Hall effect has been demonstrated in a planar cavity spintronic device, where the propagation of cavity-magnon-polaritons is deflected transversally due to hybrid magnon-photon dynamics. Implementing this device as a Michelson-type interferometer using the coherent nature of the dynamic Hall and longitudinal signals, we have developed a proof-of-principle logic device to control the amplitude of cavity-magnon-polaritons by encoding the input microwave phase.
Willingness to decrease mammogram frequency among women at low risk for hereditary breast cancer
Authors: Guan Yue , Nehl Eric , Pencea Ioana , Condit Celeste M. , Escoffery Cam , Bellcross Cecelia A. , McBride Colleen M. 
Published: July 2019

AbstractThis study aimed to assess women’s willingness to alter mammogram frequency based on their low risk for HBOC, and to examine if cognitive and emotional factors are associated with women’s inclination to decrease mammogram frequency. We conducted an online survey with women (N = 124) who were unlikely to have a BRCA mutation and at average population risk for breast cancer based on family history. Most women were either white (50%) or African American (38%) and were 50 years or older (74%). One-third of women (32%) were willing to decrease mammogram frequency (as consistent with the USPSTF guideline), 42% reported being unwilling and 26% were unsure. Multivariate logistic regression showed that feeling worried about breast cancer (Adjust OR = 0.33, p = 0.01), greater genetic risk knowledge (Adjust OR = 0.74, p = 0.047), and more frequent past mammogram screening (Adjust OR = 0.13, p = 0.001) were associated with being less willing to decrease screening frequency. Findings suggest that emerging genomics-informed medical guidelines may not be accepted by many patients when the recommendations go against what is considered standard practice. Further study of the interplay between emotion- and cognition-based processing of the HBOC screen result will be important for strategizing communication interventions aimed at realizing the potential of precision public health.
Morphological changes in response to environmental stresses in the fungal plant pathogen Zymoseptoria tritici
Authors: Francisco Carolina Sardinha , Ma Xin , Zwyssig Maria Manuela , McDonald Bruce A. , Palma-Guerrero Javier 
Published: July 2019

AbstractDuring their life cycles, pathogens have to adapt to many biotic and abiotic environmental stresses to maximize their overall fitness. Morphological transitions are one of the least understood of the many strategies employed by fungal plant pathogens to adapt to constantly changing environments, even though different morphotypes may play important biological roles. Here, we first show that blastospores (the “yeast-like” form of the pathogen typically known only under laboratory conditions) can form from germinated pycnidiospores (asexual spores) on the surface of wheat leaves, suggesting that this morphotype can play an important role in the natural history of Z. tritici. Next, we characterized the morphological responses of this fungus to a series of environmental stresses to understand the effects of changing environments on fungal morphology and adaptation. All tested stresses induced morphological changes, but different responses were found among four strains. We discovered that Z. tritici forms chlamydospores and demonstrated that these structures are better able to survive extreme cold, heat and drought than other cell types. Finally, a transcriptomic analysis showed that morphogenesis and the expression of virulence factors are co-regulated in this pathogen. Our findings illustrate how changing environmental conditions can affect cellular morphology and lead to the formation of new morphotypes, with each morphotype having a potential impact on both pathogen survival and disease epidemiology.
Systemic release of heat-shock protein 27 and 70 following severe trauma
Authors: Haider Thomas , Simader Elisabeth , Glück Olaf , Ankersmit Hendrik J. , Heinz Thomas , Hajdu Stefan , Negrin Lukas L. 
Published: July 2019

AbstractTrauma represents a major cause of morbidity and mortality worldwide. The endogenous inflammatory response to trauma remains not fully elucidated. Pro-inflammation in the early phase is followed by immunosuppression leading to infections, multi-organ failure and mortality. Heat-shock proteins (HSPs) act as intracellular chaperons but exert also extracellular functions. However, their role in acute trauma remains unknown. The aim of this study was to evaluate serum concentrations of HSP 27 and HSP 70 in severely injured patients. We included severely injured patients with an injury severity score of at least 16 and measured serum concentration of both markers at admission and on day two. We found significantly increased serum concentrations of both HSP 27 and HSP 70 in severely injured patients. Concomitant thoracic trauma lead to a further increase of both HSPs. Also, elevated concentrations of HSP 27 and HSP 70 were associated with poor outcome in these patients. Standard laboratory parameters did not correlate with neither HSP 27, nor with HSP 70. Our findings demonstrate involvement of systemic release of HSP 27 and HSP 70 after severe trauma and their potential as biomarker in polytraumatized patients.
Estimation of Transcription Factor Activity in Knockdown Studies
Authors: Trescher Saskia , Leser Ulf 
Published: July 2019

AbstractNumerous methods have been developed trying to infer actual regulatory events in a sample. A prominent class of methods model genome-wide gene expression as linear equations derived from a transcription factor (TF) – gene network and optimizes parameters to fit the measured expression intensities. We apply four such methods on experiments with a TF-knockdown (KD) in human and E. coli. The transcriptome data provides clear expression signals and thus represents an extremely favorable test setting. The methods estimate activity changes of all TFs, which we expect to be highest in the KD TF. However, only in 15 out of 54 cases, the KD TFs ranked in the top 5%. We show that this poor overall performance cannot be attributed to a low effectiveness of the knockdown or the specific regulatory network provided as background knowledge. Further, the ranks of regulators related to the KD TF by the network or pathway are not significantly different from a random selection. In general, the result overlaps of different methods are small, indicating that they draw very different conclusions when presented with the same, presumably simple, inference problem. These results show that the investigated methods cannot yield robust TF activity estimates in knockdown schemes.
Whole-Volume ADC Histogram Analysis in Parotid Glands to Identify Patients with Sjögren’s Syndrome
Authors: Chu Chen , Feng Qianqian , Zhang Huayong , Zhu Yun , Chen Weibo , He Jian , Sun Lingyun , Zhou Zhengyang 
Published: July 2019

AbstractAt present, no gold standard for diagnosing Sjögren’s syndrome (SS) is available in clinical practice. The 2002 American–European Consensus Group classification criteria are used to diagnose SS. Clinically, it is challenging to distinguish patients with SS from suspected patients undergoing different therapies. A total of 52 patients with SS and 24 patients suspected of having the disease prospectively underwent 3.0-T magnetic resonance (MR) scanning, including diffusion-weighted imaging (b = 0 and 1000 s/mm2). The whole-volume apparent diffusion coefficient (ADC) histogram analysis generated ADCmean, skewness, kurtosis, and entropy values from bilateral parotid glands. Continuous variables were compared using an independent two-sample t test, and categorical variable compared using the Fisher’s test between the two groups. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of the indexes. Fisher’s tests demonstrated that some clinical indexes and MR morphology grades differed significantly between patients with SS and patients suspected of having the disease (all P ≤ 0.001). The parotid entropy value of patients with SS was significantly higher than that of patients suspected of having the disease (P < 0.001). Among MR parameters, entropy combined with kurtosis performed the best in differentiating patients with SS from those suspected of having SS (area under the ROC curve = 0.955). A whole-volume ADC histogram analysis might provide a series of parameters that reflect tissue characteristics.
Cavity-Backed Antenna-Coupled Nanothermocouples
Authors: Szakmany Gergo P. , Orlov Alexei O. , Bernstein Gary H. , Porod Wolfgang 
Published: July 2019

AbstractThis paper reports a two-orders-of-magnitude improvement in the sensitivity of antenna-coupled nanothermocouple (ACNTC) infrared detectors. The electrical signal generated by on-chip ACNTCs results from the temperature difference between a resonant antenna locally heated by infrared radiation and the substrate. A cavity etched under the antenna provides two benefits. It eliminates the undesirable cooling of the hot junction by thermally isolating the antenna from the substrate. More importantly, careful cavity design results in constructive interference of the incident radiation reflected back to the antenna, which significantly increases the detector sensitivity. We present the cavity-depth-dependent response of ACNTCs with cavity depths between 1 μm and 22 μm. When constructive interference is maximized, the thermal response increases by 100-fold compared to devices without the cavity.
JNK and cardiometabolic dysfunction
Authors: Craige Siobhan M. , Chen Kai , Blanton Robert M. , Keaney John F. , Kant Shashi 
Published: July 2019

Abstract
Cardiometabolic syndrome (CMS) describes the cluster of metabolic and cardiovascular diseases that are generally characterized by impaired glucose tolerance, intra-abdominal adiposity, dyslipidemia, and hypertension. CMS currently affects more than 25% of the world’s population and the rates of diseases are rapidly rising. These CMS conditions represent critical risk factors for cardiovascular diseases including atherosclerosis, heart failure, myocardial infarction, and peripheral artery disease (PAD). Therefore, it is imperative to elucidate the underlying signaling involved in disease onset and progression. The c-Jun N-terminal Kinases (JNKs) are a family of stress signaling kinases that have been recently indicated in CMS. The purpose of this review is to examine the in vivo implications of JNK as a potential therapeutic target for CMS. As the constellation of diseases associated with CMS are complex and involve multiple tissues and environmental triggers, carefully examining what is known about the JNK pathway will be important for specificity in treatment strategies.
Association between PTEN and clinical-pathological features of osteosarcoma
Authors: Zhou Jian , Xiao Xia , Wang Wanchun , Luo Yingquan 
Published: July 2019

Abstract
Previous studies indicated the prognostic value of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in osteosarcoma (OS). There was a great degree of inconsistency between these reports. The aim of this meta-analysis was to investigate the clinicopathological features and prognostic role of PTEN positive expression on OS. We searched NCBI PubMed, Embase, Springer, ISI Web of Knowledge, the Cochrane library, China National Knowledge Internet database (CNKI), Wanfang database, Chinese VIP database and Chinese Biological Medical Database (CBM) for relevant papers published before 28 November 2018. The eligibility of all retrieved studies assessing the relationship between PTEN expression and clinicopathological and prognostic outcomes in OS were incorporated. Pooled odds ratio (OR) and 95% confidence intervals (CIs) were used to estimate the outcomes. A total of 13 studies with 580 OS patients were involved to assess the relationship between PTEN expression and clinicopathological features of OS. PTEN positive expression was significantly associated with male (OR = 1.57, 95% CI: 1.03–2.38, P=0.035&lt;0.05) and OS high differentiation (OR = 2.33, 95% CI: 1.26–4.29, P=0.007&lt;0.05). Additionally, positive expressions of PTEN predict no neoplasm metastasis (OR = 5.69, 95% CI: 3.64–8.90, P&lt;0.05). The results of our study showed that positive expression of PTEN may predict higher 5-year survival in OS with the pooled OR of 8.73 (95% CI: 4.18–18.24, P&lt;0.05). The results from the present study suggest that positive expression of PTEN is significantly associated with male, high differentiation, no metastasis and high 5-year overall survival rate in OS.
Newborn Hearing Screening: Early Education = More Satisfied Mothers
Authors: Krishnan Lata A. , Van Hyfte Shannon , Richards K. Andrew R. 
Published: July 2019

Newborn hearing screening (NBHS) has become the norm in all states in the United States. However, parents receive limited information about it, usually at the hospital, and have low awareness about the process. Yet parents and professionals agree that communication about the NBHS process should begin before childbirth (Arnold et al., 2006). Having information about the screening process, simply by being present for the screening and knowing the results, has been shown to positively affect parental attitudes toward NBHS (Weichbold, Welzl-Mueller, & Mussbacher, 2001).PurposeThe aim of this study was to assess whether providing expectant mothers with information related to the NBHS process in the 3rd trimester will increase their satisfaction with the NBHS program.MethodPartnering with a local obstetrician, expectant mothers were provided with information regarding NBHS. A modified version of the Parent Satisfaction Questionnaire with Neonatal Hearing Screening Program (Mazlan, Hickson, & Driscoll, 2006) was administered to mothers who received information and mothers who did not receive any education.ResultsQuantitative results indicate significantly increased satisfaction with the NBHS program when early education was received. Qualitative comments from participants support the quantitative findings.ConclusionResults suggest that educating obstetricians and their nurses about NBHS and having them provide information to expectant mothers, as well as having mothers present for the screening, may increase parental satisfaction and therefore benefit early hearing detection and intervention programs.
Communication Partner Training to Increase Interactive Communication Using Augmentative and Alternative Communication: A Case Study
Authors: Marra Lori , Micco Katie 
Published: July 2019

Purpose
The purpose of this clinical focus article was to assess the communication partner's (CP) perception regarding the effectiveness of a CP training model to support augmentative and alternative communication (AAC) use within a parent–adolescent dyad.

Method
This case study implements an adaptation of an 8-stage strategy instruction protocol for teaching aided language modeling across functional activities. Procedures for designing CP training to meet the specific needs of a particular CP and an individual using AAC (IUA) are offered. Pre- and posttraining questionnaires surveyed the CP's feelings and knowledge about using the AAC strategies and the IUA's AAC skill level.

Results
Quantitative and qualitative analyses of the CP's responses on the pre- and posttraining questionnaires revealed more confidence in supporting her son when using his device, increased knowledge of strategies to support AAC use, and increased understanding of the device operation. She also perceived that her son used his device more confidently and effectively in a variety of ways.

Conclusion
CP training that includes strategy instruction, along with practice and feedback, helps to increase the CP's and the IUA's understanding of the specific device and how to use it in more naturalistic, functional settings and situations. Since the CP's needs are similar across developmental and neurogenic groups, the direct strategy instruction described in this clinical focus article can be used by practicing clinicians working with pediatric or neurogenic populations to teach communication and operational skills. The results suggest that CP training should be included in treatment planning for speech-language pathologists working with individuals with complex communication needs who use AAC.
Self‐assisted first‐fix method for GPS receiver with autonomous short‐term ephemeris prediction
Authors: Yang Ruihong , Song Zhongguo , Xi Xiaoli 
Published: July 2019

The time needed to get the first position is one of the key parameters to assess the performance of a global position system (GPS) receiver. Here, the authors present an autonomous satellite orbit prediction algorithm to provide usable ephemeris before the broadcast ephemeris is completely collected. Experimental results show that, with the ephemeris prediction algorithm, the TTFF of the receiver saves ∼74% in cold start mode. Furthermore, the accuracy of the presented algorithm is improved by using an empirical SRP model with parameters depending on the angle between the Sun and the satellite's orbital plane. Simulation results show that, for GPS PRN 5, when the SRP model with constant parameters is used to extrapolate the orbit for 5 days, only 43% of the position error is within 10 m, but this percentage can reach to 87% using the SRP model presented here. In addition, some single point positioning experiments with simulated satellite signals and real satellite signals are conducted to analyse the positioning results of the receiver with ephemeris prediction. The experimental results verify the effectiveness of the proposed algorithm.
Diagnosis of attention deficit hyperactivity disorder using non‐linear analysis of the EEG signal
Authors: Boroujeni Yasaman Kiani , Rastegari Ali Asghar , Khodadadi Hamed 
Published: July 2019

Attention deficit hyperactivity disorder (ADHD) is a common behavioural disorder that may be found in 5%–8% of the children. Early diagnosis of ADHD is crucial for treating the disease and reducing its harmful effects on education, employment, relationships, and life quality. On the other hand, non‐linear analysis methods are widely applied in processing the electroencephalogram (EEG) signals. It has been proved that the brain neuronal activity and its related EEG signals have chaotic behaviour. Hence, chaotic indices can be employed to classify the EEG signals. In this study, a new approach is proposed based on the combination of some non‐linear features to distinguish ADHD from normal children. Lyapunov exponent, fractal dimension, correlation dimension and sample, fuzzy and approximate entropies are the non‐linear extracted features. For computing, the chaotic time series of obtained EEG in the brain frontal lobe (FP1, FP2, F3, F4, and Fz) need to be analysed. Experiments on a set of EEG signal obtained from 50 ADHD and 26 normal cases yielded a sensitivity, specificity, and accuracy of 98, 92.31, and 96.05%, respectively. The obtained accuracy provides a significant improvement in comparison to the other similar studies in identifying and classifying children with ADHD.
Anstieg des Clozapinspiegels bei bronchopulmonalen Infekten: Häufiger als man denkt!
Authors: Wilkening Anja , Palm Ulrich 
Published: July 2019

ZusammenfassungSystemische Entzündungsreaktionen können über eine Hemmung der Cytochrom-P450-Proteine die Metabolisierung verschiedener Arzneimittel beeinflussen. Hier berichten wir über 2 Patienten mit schizophrener Psychose, die während eines pulmonalen Infekts stark erhöhte Clozapinspiegel, jedoch ohne klinisch sichtbare Nebenwirkungen, aufwiesen. Nach antibiotischer Behandlung und Reduktion der Clozapindosis normalisierte sich der Clozapinspiegel nach wenigen Tagen. Bei systemischen Infekten sollte an die Möglichkeit eines erhöhten Clozapinspiegels gedacht werden.