bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy
Authors: Milan Marika , Maiullari Fabio , Chirivì Maila , Ceraolo Maria Grazia , Zigiotto Rebecca , Soluri Andrea , Maiullari Silvia , Landoni Elisa , Silvestre Dario Di , Brambilla Francesca , Mauri Pierluigi , De Paolis Veronica , Fratini Nicole , Crosti Maria Cristina , Cordiglieri Chiara , Parisi Chiara , Calogero Antonella , Seliktar Dror , Torrente Yvan , Lanzuolo Chiara , Dotti Gianpietro , Toccafondi Mirco , Bombaci Mauro , De Falco Elena , Bearzi Claudia , Rizzi Roberto 
Published: November 2024

AbstractDuchenne muscular dystrophy (DMD) is caused by the absence of the full form of the dystrophin protein, which is essential for maintaining the structural integrity of muscle cells, including those in the heart and respiratory system. Despite progress in understanding the molecular mechanisms associated with DMD, myocardial insufficiency persists as the primary cause of mortality, and existing therapeutic strategies remain limited. This study investigates the hypothesis that a dysregulation of the biological communication between infiltrating macrophages (MPs) and neurocardiac junctions exists in dystrophic cardiac tissue. In a mouse model of DMD (mdx), this phenomenon is influenced by the over‐release of chondroitin sulfate proteoglycan‐4 (CSPG4), a key inhibitor of nerve sprouting and a modulator of the neural function, by MPs infiltrating the cardiac tissue and associated with dilated cardiomyopathy, a hallmark of DMD. Givinostat, the histone deacetylase inhibitor under current development as a clinical treatment for DMD, is effective at both restoring a physiological microenvironment at the neuro‐cardiac junction and cardiac function in mdx mice in addition to a reduction in cardiac fibrosis, MP‐mediated inflammation, and tissue CSPG4 content. This study provides novel insight into the pathophysiology of DMD in the heart, identifying potential new biological targets. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
New method for predicting the free vibration characteristics of composite laminates based on generalized cell and spectral‐Tchebychev methods
Authors: Liu Xin , Li Huimin , Chen Xianglin , Zhang Xinlong 
Published: November 2024

AbstractThis paper presents a new method for analyzing the free vibration characteristics of composite laminates under arbitrary boundary conditions by integrating the generalized method of cells (GMC) and the Two‐Dimensional Spectral‐Tchebychev (2D‐ST) method. First, a meso‐macro correlation matrix is constructed based on the GMC, and the macroscopic performance parameters of the composite laminates are predicted. Then, virtual boundary springs are introduced to simulate the arbitrary boundary conditions, and the energy equation of the laminate is derived based on the first‐order shear deformation theory (FSDT) and Hamilton's principle. Furthermore, an approximate displacement function of the laminate is derived by using the 2D‐ST Tchebychev polynomials, and the Gauss‐Lobatto points are selected for meshless discretization of the structure to obtain the discretized characteristic equation, which is solved to obtain the free vibration frequency of the laminate. Based on Matlab programming, the free vibration frequencies of the laminate under different conditions are calculated, and the convergence, accuracy and computational efficiency of the calculation method are discussed, and the effects of boundary conditions, stacking angle, geometrical parameters, and material parameters on the free vibration frequencies of the laminate are analyzed. The numerical results show that the method has the advantages of fast convergence, high accuracy and high efficiency, and the method can be convenient and fast for parametric studies.Highlights
The free vibration characteristics of composite laminates are studied.
Combining generalized cell method with spectral‐Tchebychev method.
The method has the characteristics of fast convergence, high accuracy and high efficiency.
A parametric study is conducted on the free vibration of laminated panels.
An integrated population pharmacokinetic model of febuxostat in pediatric patients with hyperuricemia including gout and adult population of healthy subjects and patients with renal dysfunction
Authors: Iwama Ryutaro , Nishida Kimie , Ishii Daisuke , Iijima Takeshi 
Published: November 2024

AbstractThe study objective was to validate febuxostat dosage and administration in pediatric patients with hyperuricemia including gout, using an integrated population pharmacokinetic (PopPK) analysis in the Japanese population. Integrated PopPK analysis of febuxostat used a nonlinear mixed‐effects modeling (NONMEM) program on plasma febuxostat concentration data for 2611 samples from Japanese pediatric patients with hyperuricemia including gout (n = 29) and from adult subjects who are healthy or have renal dysfunction (n = 113). We described febuxostat pharmacokinetics using an integrated PopPK model applicable both to pediatric patients and to the adult population. The covariates of body weight and eGFR were identified for CL/F and the covariate of fasted/fed status for bioavailability. The range of steady‐state exposures (Cmax,ss and AUCτ,ss) for 5, 10, 20, and 30 mg of febuxostat in fed pediatric patients weighing 20 to 40 kg was within that for 10, 20, 40, and 60 mg of febuxostat in fed pediatric patients and adults weighing 40 to 120 kg. Post hoc estimates of CL/F, adjusted by body weight, differed little between pediatric patients and the adult population in the renal function categories of normal, mild dysfunction, and moderate dysfunction. We successfully validated the febuxostat dose that provided the same level of exposure in pediatric patients as in the adult population: half the adult dose for pediatric patients weighing <40 kg and the full adult dose for pediatric patients weighing ≥40 kg. As in adults, the results support the use of febuxostat without dose adjustment in pediatric patients who have mild to moderate renal dysfunction.
Internal Model‐Based Anti‐Disturbances Low‐Level Control for Drones Considering Actuator Dynamics
Authors: Di Jian , Kang Yu , Li Kun , Zhou Yijia , Li Pengfei 
Published: November 2024

ABSTRACTLow‐level control plays a critical role in the overall flight performance of drones. Despite some progress, existing methods do not adequately consider the complex electromechanical characteristics of actuators and aerodynamic disturbances of propellers, which deteriorates low‐level control performance. To tackle these issues, we propose a new nonlinear low‐level controller for higher precision control. First, a high‐precision low‐level model that integrates the actuator dynamics and angular velocity dynamics is presented. Based on this model, a dynamic compensator is designed using the internal model method to handle aerodynamic disturbances. Next, a high‐gain observer is designed to estimate the actuator states without adding new sensors, and an observer‐based low‐level controller is proposed through a recursive design process. Finally, the local asymptotic stability of the closed‐loop system is analyzed. The effectiveness and superiority of the proposed method are validated through simulations and physical experiments.
Integrating Anaerobic Digestion With Struvite Production for Enhanced Nutrient Recovery, Pathogen Reduction, and Circularity in Manure Management
Authors: Nagarajan Anita , Goyette Bernard , Raghavan Vijaya , Poulin‐Laprade Dominic , Rajagopal Rajinikanth 
Published: November 2024

ABSTRACTIntroductionAnaerobic digestion (AD) is essential for manure management, generating biogas and nutrient‐rich digestate for organic fertilizer. However, improper digestate use can pose environmental risks. Recovering struvite, a magnesium ammonium phosphate (MAP) compound, from digestate provides a sustainable, controlled‐release fertilizer, supporting a circular economy in agriculture.Materials and MethodsThe study employed a two‐stage (liquid–solid) AD process using poultry, dairy, and swine manures, along with wasted corn silage. Digestates were sampled for physicochemical and biogas quality analyses, with feedstocks categorized into D1 and D2, and a composite (D3) formed for struvite characterization. Microbial populations were enumerated on selective media, and struvite mineral content was analysed via argon plasma emission spectrometry.ResultsThe digesters processing feedstock mixtures D1 and D2 achieved specific methane yields of 1.26 L/g CODs fed and 1.49 L/g CODs fed, with cumulative biogas production of 374 and 369 L, respectively, over four 77‐day cycles. The two‐stage AD process significantly reduced antibiotic‐resistant, Enterobacteriaceae and Enterococcus spp. Total ammoniacal nitrogen (TAN) recovery rates were high at 98%–99%, with a consistent struvite crystal mass of 0.67 g/10 mL, indicating the efficiency of this integrated process. The agronomic value of struvite was determined, indicating its potential utility as a fertilizer, and scanning electron microscopy analysis revealed diverse crystal structures, warranting further investigation into their implications for usage and storage.ConclusionThe results suggests that the two‐stage AD process efficiently transforms organic waste into high‐quality biogas, reduces antibiotic‐resistant bacteria, and facilitates nutrient recovery through struvite precipitation. This approach supports co‐digestion of multi‐substrates and promotes circular economy principles, with potassium or sodium phosphate enhancing struvite recovery for sustainable agriculture.
Course‐Based Teacher Professional Communities (With District and Union Support) at the Center of Three‐Dimensional Science Teaching
Authors: Thomas Christie Morrison , Anderson Charles W. 
Published: November 2024

ABSTRACTThis study focuses on how two school districts managed and changed the instructional core—student learning goals, instructional resources and strategies, and assessments—in their required high school biology course as they responded to new state science standards based on the Next Generation Science Standards (NGSS). Biology teachers in both districts had access to NGSS‐aligned resources for their classrooms. Interviews with teachers, district science coordinators, and union leaders revealed how district responses were affected by two institutional logics: academic logics included the criteria that teachers used to choose resources and strategies for their classrooms and professional logics included the roles and responsibilities of district professionals. Participants from District A endorsed a common‐sense experiential academic logic, which recognized teachers' obligations to meet general criteria for content coverage while using their personal experiences and values to make detailed instructional decisions. They also endorsed a professional logic of privacy and noninterference, which recognized teachers' individual autonomy in making decisions about their classroom instructional cores. In contrast, participants from District B described how district professionals empowered a course‐based professional community to make decisions about the instructional core that all biology teachers followed in their own classrooms. We examine how this strategy enabled actions consistent with an instructional improvement logic that supported an NGSS‐aligned instructional core in all biology classrooms. We consider the implications of this contrast for teacher learning in organizational settings—the focus of this special issue.
LiNaCO3‐Containing Porous Carbon Composites for CO2 capture
Authors: Li Honghao , Adili Guliqire , Tuerxun Nasiman 
Published: November 2024

AbstractIn this study, LiNaCO3‐ and (Li‐Na‐K)2CO3‐based porous carbon composites were synthesized from terephthalic acid, lithium hydroxide, sodium hydroxide, and potassium hydroxide at different calcination temperatures. These composite materials were characterized with X‐Ray diffraction, scanning electron microscopy, and nitrogen adsorption and desorption. According to their CO2 capture performance measured, LiNaC‐700 °C had the largest CO2 adsorption capacity of 66 mg CO2 g−1, while the CO2 capture capacity of other materials doped with three metal ions was only up to 8.57 mg CO2 g−1. Additionally, the CO2 adsorption capacity of each adsorbent was significantly higher than the N2 adsorption capacity, showing their high CO2 adsorption selectivity. Lithium‐containing carbonate‐based porous carbon materials (LiNaCO3‐ and (Li‐Na‐K)2CO3‐based porous carbon could effectively capture CO2 with excellent reproducibility.
Unveiling Novel Hybrids Quinazoline/Phenylsulfonylfuroxan Derivatives with Potent Multi‐Anticancer Inhibition: DFT and In Silico Approach Combining 2D‐QSAR, Molecular Docking, Dynamics Simulations, and ADMET Properties
Authors: Guendouzi Abdelmadjid , Belkhiri Lotfi , Guendouzi Abdelkrim , Culletta Giulia , Tutone Marco 
Published: November 2024

AbstractIn this work, the biological activities of 29 novel quinazoline/phenylsulfonylfuroxan derivatives (1a–z, 1aa, 1ab, 2a, 2b, 2d, and 2f) were computationally investigated as potential anti‐cancer inhibitors against five cell lines, i.e., H1975, MCF‐7, Eca‐109, MGC‐803, and A549, which are involved in various diseases, including lung, breast, esophageal squamous carcinoma, and gastric cancer. The 2D‐QSAR predictive approach, exploiting multiple linear regression (MLR) models and rigorous internal and external cross‐validation, showed a correlation factor R2 of range: 0.68−0.82. Moreover, the MLR‐derived R2test and Y randomization (R2rand) values for the five cell lines are higher than 0.60 and less than 0.3, respectively, indicating a strong alignment with the internal and external validation data. New 70 quinazoline hybrids based on the most effective in vivo 1q inhibitor were designed, and their pIC50 activity was predicted. The best‐scoring 15 (N1–N15) compounds were further evaluated using molecular docking and dynamics simulations (100 ns) with the VEGFR‐2 kinase target (PDB code: 3U6J). All the data sets accurately predict the strongest binding affinity for the selected (N6, N7, N9, and N11) molecules, as evidenced by the highest docking score, hydrogen bond energy, and significant amino acid steric interactions. Furthermore, the RMS/RMSF/Rg dynamics parameters show that the formed complexes are satisfactorily stable. The ADMET properties indicate that the selected new ligands have shown a promising drug‐like profile and can be considered potential candidates for future anti‐cancer therapies, with perspective validating their anticancer activity by in vitro and in vivo studies.
Size and Surface Effects in the Ultrafast Dynamics of Strongly Cooperative Spin‐Crossover Nanoparticles
Authors: Haddock Tyler N. , Delgado Teresa , Alías‐Rodríguez Marc , de de Graaf Coen , Enachescu Cristian , van der Veen Renske M. 
Published: November 2024

AbstractCooperative photoinduced switching of molecular materials at the nanoscale is still in its infancy. Strongly cooperative spin‐crossover nanomaterials are arguably the best prototypes of photomagnetic and volume‐changing materials that can be manipulated by short pulses of light. Open questions remain regarding their non‐equilibrium dynamics upon light excitation and the role of cooperative elastic interactions in nanoscale systems that are characterized by large surface/volume ratios. Femtosecond‐resolved broadband spectroscopy is performed on nanorods of the strongly cooperative Fe‐triazole, which undergoes a reversible low‐spin to high‐spin (HS) phase transition ≈360 K. Supported by density functional theory and mechano‐elastic Monte Carlo simulations, a marked difference is observed in the photoswitching dynamics at the surface of the nanoparticles compared with the core. Surprisingly, under low excitation (<2%) conditions, there occurs a transient increase in the HS population at the surface on the picosecond time scale, while the HS population in the core decays concomitantly. These results shed light onto the importance of surface properties and dynamical size limits of nanoscale photoresponsive nanomaterials that can be used in a broad range of applications.
Ultra‐thin C/Si Shell Pieces as Amphiphilic Janus Materials for Efficient Oxidation Desulfurization
Authors: Zhang Hongyu , Liu Bolun , Jin Wenhui , Xiong Zeshan , Yang Aili , Guo Pengyu , Wang Runwei , Zhang Zongtao 
Published: November 2024

AbstractConstructing favorable morphology is considered to be an effective strategy to enhance the amphiphilic performance of materials. The directional alignment of ultra‐thin lamellar materials significantly facilitates utilization of active sites at the bi‐phase interface. Herein, an ultra‐thin amphiphilic C/Si shell pieces Janus material (d = 10.4 nm) prepared by graphene oxide and SiO2 is reported. The outer SiO2 layer is associated with hydrophilicity, while the inner C layer exhibits hydrophobicity. A Pickering emulsion interface catalyst for fuel oil oxidative desulfurization is constructed by impregnating an amino‐modified C/Si Janus material with keggin‐type HPW. The results demonstrate that amphiphilic catalyst with an ultra‐thin C/Si shell pieces exhibits superior performance in terms of emulsification rate (100%) and desulfurization rate (99.62%) in the O/W emulsion formed by n‐octane/acetonitrile. The catalyst demonstrates the advantages of easy recovery and regeneration, maintains a higher activity after oxidative desulfurization (ODS) process, and has higher industrial application value.
Structural and Phase Engineering of a Hierarchical 2D–2D Nickel MOF/Hydroxide‐Derived Ni0.85Se/NiTe2 Heterointerface for Robust HER, OER, and Overall Water Splitting
Authors: Pathak Ishwor , Prabhakaran Sampath , Acharya Debendra , Chhetri Kisan , Muthurasu Alagan , Rosyara Yagya Raj , Kim Taewoo , Ko Tae Hoon , Kim Do Hwan , Kim Hak Yong 
Published: November 2024

AbstractThe development of a nonnoble metal‐based cost‐effective, efficient, and durable bifunctional electrocatalyst is crucial to achieving the goal of carbon neutrality. In this study, a structural and interfacial engineering approach is employed to design a 2D–2D hierarchical nickel MOF/nickel hydroxide‐derived nickel selenide/nickel telluride dual‐phase material through a single‐step selenotellurization process. The rational design of highly ordered nanoarchitectures provides well‐defined voids and ample pathways for ion diffusion. Furthermore, hierarchical nickel selenide/nickel telluride works synergistically at heterojunctions, providing a local ion enrichment mechanism for the catalytic process. As a result, Ni0.85Se/NiTe2@Ni‐NH@CC needs an overpotential of 69 and 240 mV to deliver a current density of 10 mA cm−2 for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), respectively, with an outstanding stability observed for over 100 h. Moreover, the Ni0.85Se/NiTe2@Ni‐NH@CC (+, −) device exhibits excellent overall water‐splitting performance with a cell voltage of 1.50 V at 10 mA cm−2 and can be operated steadily for >100 h at 100 mA cm−2. Density functional theory (DFT) calculations indicate favorable kinetics for H‐adsorption at the selenotelluride heterojunction, thereby promoting the HER. This work highlights a new approach for designing a unique nanoarchitecture of MOF/hydroxide‐derived selenotelluride heterojunctions for high‐efficiency energy conversion applications.
Ultra‐High Activity and Durability of Low‐Platinum Fuel Cells Enabled by Encapsulation of L10‐PtCo and L12‐Pt3Co Intermetallic Compounds
Authors: Li Gong , Bai Jingsen , Liu Changpeng , Jin Zhao , Xiao Meiling , Xing Wei 
Published: November 2024

AbstractDeveloping high‐performance, durable, and ultralow‐loading platinum (Pt) catalysts for the oxygen reduction reaction (ORR) is crucial for advancing fuel cells. Here, a novel structured alloy catalyst is reported, characterized by Pt‐Co intermetallic compounds with a Pt‐skin, encapsulated by a covalent organic framework (COF) derived carbon support. This unique structure, combining alloy‐induced strain effects and protective encapsulation, leads to exceptional catalytic activity and stability at an ultralow Pt loading of 0.02 mgPt cm−2. To be specific, this catalyst exhibits peak power densities of 1.77 W cm−2 in fuel cell tests. It demonstrates a state‐of‐the‐art mass activity of 2.15 A mgPt−1 (@0.9 V), which is 5.38 times that of commercial Pt/C (0.40 A mgPt−1). More importantly, the fuel cell assembled with this novel catalyst displays exceptional durability, with a voltage degradation of only 9.9 mV after 100,000 cycles at 0.8 A cm−2 and a mass activity retention of 85% (1.83 A mgPt−1), far exceeding the 2025 initial mass activity (MA) target (0.44 A mgPt−1) of DOE by 4.2 times. Notably, the current density at 0.6 V under hydrogen‐air conditions shows only a slight decline after more than 230 h.
Perfluoropolyether‐terminated Single‐ion Polymer for Enhancing Performance of PEO‐based Solid Polymer Electrolyte
Authors: Wang Tianyi , Guo Yuxiang , Ren Kailiang , Liang Jin , Chen Xiaoyi , Luo Hebin , Ma Yue , Kong Jie 
Published: November 2024

AbstractSolid‐state electrolytes are receiving increasing attention in lithium metal batteries due to the advantage of high energy density. Poly(ethylene oxide) (PEO) electrolyte possesses good compatibility with lithium salts. However, PEO suffers from a low lithium‐ion transference number and poor high‐voltage resistance, which significantly hinder its application in lithium metal batteries. Herein, a perfluoropolyether‐terminated single‐ion polymer (PFPE‐polymer) is designed and synthesized in this contribution. By incorporating the PFPE‐polymer and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) into PEO via casting, the polymer electrolyte (PFPE‐SE) is successfully prepared. Compared to PEO‐based electrolytes, PFPE‐SE forms a solid electrolyte interface (SEI) layer and inhibits the growth of lithium dendrites on the anode. At 70 °C, the lithium‐ion transference number and the electrochemical window reach 0.72 and 4.7 V, respectively. When tested at a discharge rate of 0.5 C, the Li|PFPE‐SE|LFP cell exhibits a specific capacity of 156.0 mAh g−1, with a capacity retention of 74.3% after 230 cycles, superiority the performance of the electrolyte prepared by mixing PEO with LiTFSI. This work presents a promising polymer electrolyte strategy for achieving high‐performance lithium metal batteries, leveraging the in situ construction of the SEI layer and the utilization of a single‐ion polymer.