bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of STING complex in differential retrograde signaling in cybrids with K versus H haplogroup mtDNA
Authors: Schneider Kevin , Chwa Marilyn , Atilano Shari R. , Nashine Sonali , Udar Nitin , Boyer David S. , Jazwinski S. Michal , Miceli Michael V. , Nesburn Anthony B. , Kuppermann Baruch D. , Kenney M. Cristina 
Published: August 2018

ABSTRACTMitochondrial (mt) DNA haplogroups, defined by specific single nucleotide polymorphism (SNPs) patterns, represent populations of diverse geographic origins and may play a role in disparate disease susceptibilities found in different ethnic/racial populations. The most common European haplogroup is H, while the K haplogroup is highly associated with Ashkenazi Jewish populations. Studies using transmitochondrial cybrids (cell lines with identical nuclei but mitochondria from either H or K haplogroup subjects) demonstrated significant molecular and biological differences but mechanisms for these disparities are unclear. In this study, we hypothesized that there is differential retrograde signaling occurring between the Stimulator of Interferon Genes (STING) pathway and H versus K mtDNA haplogroups. Results showed that K cybrids exhibit increased levels of cytoplasmic mtDNA fragments. After STING Knock-Down, H cybrids had lower expression levels for EGFR, BRCA1, DNMT3A, DNMT3B, HDAC1, and IFNα genes, but upregulated DNMT3A compared to control H cybrids. The STING-KD K cybrids showed downregulation of EGFR, DNMT3A, HDAC1, HCAD9, CFH, and CHI, along with upregulation of DNMT1 and IL-6 compared to control K cybrids. Since all cybrids have identical nuclei, the STING DNA sensor system interacts differently with K haplogroup mtDNA compared to H mtDNA for genes related to cancer (EGFR, BRCA1), methylation (DNMT1, DNMT3A, DNMT3B), acetylation (HDAC1, HDCA9), complement (CFH, CHI) and inflammation (IFNα, IL-6). In summary, in non-pathologic conditions, (a) STING is an important retrograde signaling mechanism(s) and (b) cybrids possessing Ashkenazi Jewish mtDNA (K haplogroup) interact with the STING complex differently compared to H cybrids which affects various disease-related pathways.
Cardiometabolic Recovery and Lactate Removal may be Related to Muscular Adaptations
Authors: Alarcón Meza Edgar Ismael , de Oliveira Glauber Lameira , de Oliveira Talita Adão Perini , Moreira Marcelo Hubner , Militão Angeliete Garcez , Filho José Fernandes , Da Silva Vernon Furtado , Martin Dantas Estélio Henrique , Valentim-Silva João Rafael 
Published: August 2018

AbstractThe aim of this study was to measure the differences in cardiorespiratory recovery (CR) and blood lactate removal among young athletes with differences in non-lactic (NP) and lactic anaerobic power (LP) and fatigue index (FI) but with the same degree of cardiorespiratory fitness. Sixteen swimmers from the Brazilian synchronized swimming team (2014) were divided into two groups GAP (Group High Power) (n = 9), with NP, LP, and FI (p<0.05) compared to GBP (Group Low Power) (n=7). Both groups performed a four-minute routine at competitive intensity. Anaerobic power, maximal heart rate (HR) and blood lactate (BL) were determined before and at 1, 3 and 5 minutes after the routine. Student’s t-test was used to analyze the intergroup differences of NP, LP, FI, maximum and lactic HR, and two-way ANOVA followed by Bonferroni was used to analyze HR and BL at 1, 3 and 5 minutes after activity with a significance of 5%. The FI of the GBP group was lower than that of the GAP group (P <0.05). The NP of the GBP group was higher than that of the GAP group (P <0.05). The maximum HR of the GBP group was equal to that of the GAP group (P> 0.05). The GBP group had better HR recovery than did the GAP group (P <0.05). BL had its lowest levels after 1 and 5 minutes of recovery in the GBP group when compared to the GAP group (P <0.05). The GBP group’s FI was significantly lower than that of the GAP group, while NP was higher, and CR was better in the GBP group, indicating a relationship between a lower FI and higher NP and LP with CR and suggesting that muscular adaptations have an important influence on CR and BL removal.
An open-source software analysis package for Microspheres with Ratiometric Barcode Lanthanide Encoding (MRBLEs)
Authors: Harink Björn , Nguyen Huy , Thorn Kurt , Fordyce Polly 
Published: August 2018

AbstractMultiplexed bioassays, in which multiple analytes of interest are probed in parallel within a single small volume, have greatly accelerated the pace of biological discovery. Bead-based multiplexed bioassays have many technical advantages, including near solution-phase kinetics, small sample volume requirements, many within-assay replicates to reduce measurement error, and, for some bead materials, the ability to synthesize analytes directly on beads via solid-phase synthesis. To allow bead-based multiplexing, analytes can be synthesized on spectrally encoded beads with a 1:1 linkage between analyte identity and embedded codes. Bead-bound analyte libraries can then be pooled and incubated with a fluorescently-labeled macromolecule of interest, allowing downstream quantification of interactions between the macromolecule and all analytes simultaneously via imaging alone. Extracting quantitative binding data from these images poses several computational image processing challenges, requiring the ability to identify all beads in each image, quantify bound fluorescent material associated with each bead, and determine their embedded spectral code to reveal analyte identities. Here, we present a novel open-source Python software package (the mrbles analysis package) that provides the necessary tools to: (1) find encoded beads in a bright-field microscopy image; (2) quantify bound fluorescent material associated with bead perimeters; (3) identify embedded ratiometric spectral codes within beads; and (4) return data aggregated by embedded code and for each individual bead. We demonstrate the utility of this package by applying it towards analyzing data generated via multiplexed measurement of calcineurin protein binding to MRBLEs (Microspheres with Ratiometric Barcode Lanthanide Encoding) containing known and mutant binding peptide motifs. We anticipate that this flexible package should be applicable to a wide variety of assays, including simple bead or droplet finding analysis, quantification of binding to non-encoded beads, and analysis of multiplexed assays that use ratiometric, spectrally encoded beads.
Enterotype-like microbiome stratification as emergent structure in complex adaptive systems: A mathematical model
Authors: Martín Miguel Ángel 
Published: August 2018

AbstractBackgroundMetagenomics has provided valuable insight into human gut microbiome composition together with its structure and function. Studies suggest that the adult gut microbial community possess a certain amount of stability and resilience. The architecture of host-microbial symbiotic states suggested by microbiome clustering findings and co-occurrence functional networks might be involved in these properties. Models for understanding the underlying structure (including enterotypes) and derived properties are in demand by researchers.Principal findingsWe propose a simple random function system as a model approach of the adaption and self-organization of the microbiome space when fostering the optimal functioning of the system. The construction of this model is based on key facts of microbiota functioning reported in recent studies. We aim to demonstrate the existence of a probability distribution as a microbiome attractor resulting from an intermittent adaption process. Its mathematical structural properties explain the stability of gut microbiota and its ability for restoration after occasional perturbations. The model is consistent with microbiome clustering results and provides precise mathematical meaning to the gradient among enterotypes previously reported. The model also explains how intermittent perturbations, such as long-term dietary patterns, might affect the microbiome structure, and these results are consistent with previously reported experimental results.Conclusions/significanceThese mathematical facts implied by the model unveil an underlying mechanism that may explain gut microbiome structure and related experimental findings. Within this framework, stability and resilience properties of human gut microbiota are explained as a consequence of the model.
Impaired translations: IFRS from English and annual reports into English
Authors: Nobes Christopher , Stadler Christian 
Published: August 2018

Purpose
The purpose of this paper is to examine translation in the context of International Financial Reporting Standards (IFRS) by taking the example of the English term “impairment” in IAS 36, and following it into 19 translations. The paper then examines the terms used for impairment in English translations of annual reports provided by firms. Consideration is given to the best approach for translating regulations and whether that is also suitable for the translation of annual reports.

Design/methodology/approach
The two empirical parts of the paper involve: first, identifying the terms for impairment used in 19 official translations of IAS 36, and second, examining English-language translations of reports provided by 393 listed firms from 11 major countries.

Findings
Nearly all the terms used for “impairment” in translations of IAS 36 do not convey the message of damage to assets. In annual reports translated into English, many terms are misleading in that they do not mention impairment, peaking at 39 per cent in German and Italian reports in one year.

Research limitations/implications
Researchers should note that the information related to impairment in international databases is likely to contain errors, and the authors recommend that data should be hand-collected and then carefully checked by experts. The authors make suggestions for further research.

Practical implications
Translators of regulations should aim to convey the messages of the source documents, but translators of annual reports should not look only at the reports but also consult the terminology in the original regulations. The authors also suggest implications for regulators and analysts.

Originality/value
The paper innovates by separately considering regulations and annual reports. The authors examine a key accounting term systematically into a wide range of official translations. The core section of the paper is a new field of research: an empirical study of the translations of firms’ financial statements.
Accounting and the banality of evil
Authors: Antonelli Valerio , D’Alessio Raffaele , Rossi Roberto , Funnell Warwick 
Published: August 2018

PurposeThe purpose of this paper is to identify the significant role of accounting in the expropriation of Jewish real estate after the enforcement of race laws under Benito Mussolini’s Fascist regime in Italy.Design/methodology/approachHannah Arendt’s understanding of government bureaucracy in the twentieth century totalitarian regimes informs the research which draws upon a wide range of primary sources.FindingsImplementation of the program of expropriation was the responsibility of a government body, EGELI, which was created specifically for this purpose. The language of accounting provided the means to disguise the nature and brutality of the process and allow bureaucrats to be removed from the consequences of their actions. Accounting reports from EGELI to the Ministry of Finance confirmed each year that those who worked in EGELI were devoted to its mission as an agency of the Fascist State.Research limitations/implicationsThe findings of this study recognize the need for further research on the role played by servicemen, bureaucrats and accounting as a technology of government in the deportation of Italian Jews to Germany. The study also provides impetus to examine how other countries managed the properties confiscated or expropriated from the Jews in the earlier stages of the Final Solution.Originality/valueThe study is the first to identify the significant role played by accounting and accountants in the persecution of Italian Jews under the Fascism.
The use of food quality and prestige-based benefits for consumer segmentation
Authors: Heide Morten , Olsen Svein Ottar 
Published: August 2018

Purpose
The purpose of this paper is to identify consumer segments based on the importance of food quality and prestige benefits when buying food for a special occasion; dinner party with friends.

Design/methodology/approach
Using cluster analysis, the importance of food quality benefits (quality, taste and health) and prestige benefits (prestige quality, hedonic, uniqueness, price and social) were investigated. The consumer segments were profiled using individual consumer characteristics (involvement in luxury, willingness to pay and socio-demographics).

Findings
Food quality benefits are the most important benefits when buying food for a party with friends and the authors identified four distinct consumer segments based on 20 different food quality and prestige benefits: perfectionists, premium, luxury seeking and value focussed. Three of the four consumer segments (perfectionists, premium and luxury seeking) find conventional food quality benefits important but differ in the importance they attribute to the different prestige benefits. The value focussed segment is not driven by prestige consumption but wants high quality at an affordable price.

Research limitations/implications
This study demonstrates that consumers are driven by different food and prestige benefits when buying food for a special occasion.

Originality/value
This study suggest some important differences between premium consumers, looking for food quality and hedonic benefits, and luxury seeking, with a relatively higher focus on prestige quality, uniqueness and social benefits. This study also identifies a significant distinction between perfectionists and value focussed consumers. Both segments are focussed on food quality benefits but differ in their focus on value and prestige benefits.
Measures aiding in identifying voluntarily helpful employees: an accounting student sample
Authors: Lyons Paul , Bandura Randall P. 
Published: August 2018

PurposeThere have been few attempts to identify valid and efficient self-assessment measures for use by human resource practitioners or line managers to help distinguish job applicants and/or employees who may have a predisposition to offer voluntary helpful behavior, or contextual performance, on the job. This paper (exploratory and correlational) aims to identify measures that are positively and highly related to this valuable work behavior. Findings set the stage for further study and research aimed at creating predictive measures that possess reliable statistical properties.Design/methodology/approachStudy design has two components: first, identity and analysis of measures of performance that are broadly supported in research literature; and second, correlational analysis of contextual performance measures with critical self-assessments. No effort to discover cause and effect linkages is reported; only relationships are disclosed.FindingsOf the self-assessments examined, two (core self-evaluation and self-efficacy) were found to be positively and significantly related to valid measures of voluntary, helpful organizational behavior, in this case, measures of contextual performance and job dedication.Research limitations/implicationsThe study made no attempt to establish statistically valid predictors of behavior. Sample size was relatively small and consisted of students preparing for a career in accounting.Originality/valueVoluntary, helpful employee behavior is valuable in virtually all organizations. Isolated here are two brief and easy-to-administer self-assessments which may assist in the identification of individuals who possess an inclination to offer such behavior.
Mentors of preservice teachers
Authors: Lejonberg Eli , Elstad Eyvind , Sandvik Lise Vikan , Solhaug Trond , Christophersen Knut-Andreas 
Published: August 2018

PurposeThe purpose of this paper is to discuss how different styles of mentoring in teacher education relate to mentor characteristics. Pre-service teachers often want practical advice. However, in Norway, school mentors have traditionally been encouraged to promote reflection rather than offering advice. This study seeks to explore the relationship between mentors’ support for reflection based and clear mentoring (a relatively direct approach to mentoring) and mentors’ self-efficacy and effort.Design/methodology/approachUsing structural equation modelling of cross-sectional survey data (from 272 school mentors), the researchers in this study tested empirical interrelations between reflection-based mentoring, clear mentoring, mentor efficacy and effort. Clear mentoring was a reasonably consistent construct, while refection-based mentoring was a more elusive concept.FindingsEffort was associated with support for reflection, while self-efficacy was moderately related to clear mentoring and reflection-based mentoring. The results illustrate that reflection-based methods are demanding for mentors. If direct approaches are more effective, additional evidence would be required to support mentor training that heavily emphasises reflection.Research limitations/implicationsLongitudinal and quasi-experimental studies are needed to support inferences about causality. Variable omission may have influenced the models. More research is needed to better understand the concept of reflection-based mentoring.Originality/valueThis paper contributes to the mentoring field by examining mentors’ preference for reflection based and clear mentoring and how such preferences are related to self-efficacy and effort. It also contributes to general and theoretical discussions about the relationships between beliefs about mentoring and mentor characteristics.
Developing citizen leadership in Myanmar: the DeBoer fellowship
Authors: Steffensmeier Timothy , McBride Julia Fabris , Dove Peter 
Published: August 2018

Purpose
The purpose of this paper is to understand the impact of the DeBoer fellowship, a citizen leadership development program in Myanmar. The challenge in Myanmar of catalyzing transformative change facing government and civil society cannot be overstated. Autocratic, centralized, and a traits-based approach to leadership has been, until recently, the primary way to assess leaders in Myanmar. In this dynamic civic context, new ways of leading and learning are needed.

Design/methodology/approach
Interviews of DeBoer fellowship alumni were analyzed using a single case study method. The project focuses on individual participants of the program as the primary unit of analysis. In addition, direct observation and contributions from DeBoer fellowship administration and faculty were used to describe this case study.

Findings
The DeBoer fellows understood their challenge as one of energize others, a concept of adaptive leadership. Moreover, individuals experienced deep degrees of transformational development. Civic agency was the least noticable concept that was studied.

Research limitations/implications
Future research could more explicitly measure and examine the degree to which civic agency is being nurtured in leadership development programs.

Practical implications
Civic leadership curriculum designers should be more conscious of adult development theory when choosing programming objectives and activities.

Social implications
Leadership development initatives in more authoritative systems can be effective developmental experiences for participants who are motivated to improve their organizations and communities.

Originality/value
To the authors’ knowledge, this is the first effort to analyze a citizen leadership program in Myanmar.
Paradigms and paradoxes: the futures of growth and degrowth
Authors: Pesch Udo 
Published: August 2018

Purpose
The purpose of this paper is to introduce three storylines that address the relation between economic growth, technical innovation and environmental impact. The paper assesses if and how these storylines as guiding visions increase our range of future orientations.

Design/methodology/approach
The paper first explains its general outline and then explores different strands of literature to arrive at its analytical conclusions.

Findings
Pursuing the three storylines in a paradigmatic articulation creates paradoxes. The growth paradigm focuses on economic growth as its main goal. To overcome environmental degradation, products have to be substituted by environmentally friendly alternatives, but the continuous substitution of finite resources seems unlikely possible. The storyline of innovation sees technological development as a driver of economic progress, and holds that innovations allow the decoupling of economic growth from environmental impact, a claim that is compromised by the occurrence of rebound effects. The degrowth storyline holds that economic growth has to be stopped altogether, but is unclear how this can be done.

Originality/value
By articulating paradigmatic perspectives as storylines, a new understanding on how these perspectives can be figured as a constructive repertoire of guiding visions and not as mere theory-based descriptions.
Does religious affiliation influence trust?
Authors: Kortt Michael A. , Drew Joseph 
Published: August 2018

PurposeThe purpose of this paper is to estimate and explore how religious affiliation may influence general and local trust in contemporary society.Design/methodology/approachThis paper employs data from the 2010 and 2014 waves of the Household, Income and Labour Dynamics in Australia survey. The association between religious affiliation and trust was estimated using an ordered logistic regression and conventional ordinary least squares model.FindingsThe paper presents evidence of a statistically significant association between religious affiliation and trust that are consistent with theory.Social implicationsThis finding is important for a heterogeneous population like Australia as it seeks to build social cohesion in the face of threats to internal and external security.Originality/valueThe study contributes to the literature by providing – to the best of the authors’ knowledge – the first results on the association between religious affiliation and trust for Australia.
Using SEM-PLS to assess users satisfaction of library service quality: evidence from Malaysia
Authors: Choshaly Sahar Hosseinikhah , Mirabolghasemi Marva 
Published: August 2018

Purpose
The purpose of this paper is to examine the impact of Libqual+™ dimension (affect of services, information control and Library as a place) on user satisfaction at Universiti Kebangsaan Malaysia (UKM).

Design/methodology/approach
Data were collected using a sample of 100 students and it was analyzed using SPSS and SmartPLS. The measurement model was analyzed using composite reliability, convergent and discriminate validity while the structural model was used to predict the relationships between variables.

Findings
The results indicated that services, information control and library as a place have a significant and positive impact on the overall satisfaction of library users, with affect of services being the most important predictor of library user satisfaction.

Practical implications
Overall, users are satisfied with the services provided by the UKM library. Results from this study will help librarians to make better decisions in providing effective services and fulfilling the library’s vision and mission.

Originality/value
The study provides insight into the UKM University how to use LibQual+™ dimension to improve user’s satisfaction.