bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Interhemispheric and Transsylvian Approach for Resection of Craniopharyngioma
Authors: Inoue Tomohiro , Ono Hideaki , Tamura Akira , Saito Isamu 
Published: February 2018

AbstractWe present a 37-year-old male case of cystic suprasellar huge craniopharyngioma, who presented with significant memory disturbance due to obstructive hydrocephalus. Combined interhemispheric and pterional approach was chosen to resect huge suprasellar tumor. Interhemispheric trans-lamina terminalis approach was quite effective to resect third ventricular tumor, while pterional approach was useful to dissect tumor out of basilar perforators and stalk.The link to the video can be found at: https://youtu.be/BoYIPa96kdo.
The “Auto-sliding Graft” Aortic Wrapping Technique
Authors: Estevez-Cid Francisco , Herrera-Norena Jose María , de Sierra Carlos Velasco-García 
Published: February 2018

AbstractWe describe the “auto-sliding graft” technique, a different anastomotic option for reconstructive prosthetic procedures on the ascending aorta especially in patients at risk of circulatory arrest with mild aortic dilatation. This simple technique provides not only an important hemostatic reinforcement for the distal aortic graft anastomosis but also a protective effect on the native ascending aorta beyond the suture line.
Individuelle Therapie
Authors: Maier Klaus-Jürgen , Knobe Matthias 
Published: February 2018

Zusammenfassung
Einführung Die Therapie der Altersfrakturen stellt aufgrund der meist vorliegenden Multimorbidität der
geriatrischen Patienten für alle beteiligten Berufsgruppen eine große Herausforderung dar – von der
Indikationsstellung bis zur Nachbehandlung. Im Schwerpunkt beschreiben wir Schritt für Schritt die individuell
abgestimmten Behandlungsmöglichkeiten für typische Altersfrakturen.
Demenzsensible Versorgung
Authors: Spitzner Katja , Morgenstern Ulrike 
Published: February 2018

Zusammenfassung
Menschen mit Demenz im OP Die Zahl älterer Patienten wächst stetig an, was gleichzeitig zu einer Zunahme
an demenzkranken Patienten führt. Viele Faktoren im Klinikalltag bewirken, dass ihre besonderen Bedürfnisse
nicht ausreichend berücksichtigt werden. Wie die Versorgung im Akutkrankenhaus und speziell im OP für Menschen
mit Demenz angemessener gestaltet werden kann, schildern unsere Autorinnen.
Quo vadis Datenlinkage in Deutschland? Eine erste Bestandsaufnahme
Authors: March Stefanie , Antoni Manfred , Kieschke Joachim , Kollhorst Bianca , Maier Birga , Müller Gabriele , Sariyar Murat , Schulz Mandy , Enno Swart , Zeidler Jan , Hoffmann Falk 
Published: February 2018

ZusammenfassungDie Verknüpfung verschiedener Datenquellen, genannt Datenlinkage oder auch Record Linkage, zur Beantwortung von wissenschaftlichen Fragestellungen findet in den letzten Jahren in Deutschland vermehrt Anwendung. Jedoch mangelt es bisher an publizierten Erfahrungen. Neue Projekte erarbeiten sich in der Regel autark voneinander das notwendige Handwerkszeug. Daher hat sich eine Gruppe von Forschern zusammengefunden, um ihre Erfahrungen zum Datenlinkage in Deutschland als mögliche Hilfestellung bzw. Anregung für Projekte, Gutachter sowie Datenschützer und Ethikkommissionen zusammenzustellen. Ziel dieser ersten Bestandsaufnahme zum Datenlinkage ist es deshalb, eine Unterstützung für zukünftige Projekte zu liefern, die Daten aus Deutschland auf individueller Ebene verknüpfen möchten. Neben den (datenschutz-)rechtlichen Rahmenbedingungen werden dabei auch praxisorientiert die Arten des Datenlinkage, deren Anwendungsfelder und Ansätze zur Vermeidung von Fehlern anhand von Beispielen dargestellt.
Multimodale Schmerztherapie bei traumatisierten Patienten
Authors: Söllner Wolfgang , Venkat Sandra 
Published: February 2018

SummaryIn Schmerzzentren werden häufig Patienten mit Traumatisierung in Kindheit und Jugend und teilweise auch anhaltenden posttraumatischen Belastungsstörungen behandelt. Die Traumatisierung wird oft erst im Rahmen einer multimodalen Schmerztherapie (MMST) erkannt. Die Mitarbeiter von Schmerzeinrichtungen, die eine MMST anbieten, sollten über den Umgang und die Behandlung von traumatisierten Schmerzpatienten geschult werden. Ein zweizeitiges Behandlungsverfahren wird vorgeschlagen: Nach einer MMST sollte eine weiterführende traumatherapeutisch fokussierte psychosomatische Behandlung angeschlossen werden.
Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss
Authors: Raynaud-Messina Brigitte , Bracq Lucie , Dupont Maeva , Souriant Shanti , Usmani Shariq M. , Proag Amsha , Pingris Karine , Soldan Vanessa , Thibault Christophe , Capilla Florence , Al Saati Talal , Gennero Isabelle , Jurdic Pierre , Jolicoeur Paul , Davignon Jean-Luc , Mempel Thorsten R. , Benichou Serge , Maridonneau-Parini Isabelle , Vérollet Christel 
Published: February 2018

SignificanceBone deficits are frequent complications observed in HIV-1–infected patients. Our study demonstrates that HIV-1 infects osteoclasts, the cells specialized in bone degradation, using different models including HIV-1–infected humanized mice. We decipher the cellular mechanisms by which HIV-1 contributes to enhanced bone degradation in human osteoclasts, showing that the virus modifies the structure and function of the sealing zone, the bone resorption machinery of osteoclasts. We identify the viral protein Nef as the key factor responsible for such effects. As a proof-of-concept, we correlate bone deficit in transgenic Nef-expressing mice with enhanced osteoclast activity. Therefore, our findings provide formal evidence that osteoclasts constitute HIV-1 host target cells, contributing to bone deficits in vivo.
Climate-mediated hybrid zone movement revealed with genomics, museum collection, and simulation modeling
Authors: Ryan Sean F. , Deines Jillian M. , Scriber J. Mark , Pfrender Michael E. , Jones Stuart E. , Emrich Scott J. , Hellmann Jessica J. 
Published: February 2018

Significance
The biological consequences of climate change are determined by the responses of individual species and interactions among species. Hybridization, or interbreeding between related species, is an interaction that affects how species evolve in response to environmental change. Here we provide evidence that climatic warming has caused a geographic shift of a butterfly hybrid zone and that strong selection and/or genetic incompatibilities maintain species boundaries during this movement. Through simulations, we show that as climate change progresses, the rate and geographic configuration of future hybrid zone movement will vary across space and time. This geographic variation in future hybrid zone movement may lead to divergent ecological and evolutionary outcomes, and thus has implications for local conservation and management.
STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles
Authors: Vlijm Rifka , Li Xue , Panic Marko , Rüthnick Diana , Hata Shoji , Herrmannsdörfer Frank , Kuner Thomas , Heilemann Mike , Engelhardt Johann , Hell Stefan W. , Schiebel Elmar 
Published: February 2018

Significance
The integrity of the centrosome linker that joints both centrosomes of a cell into one microtubule-organizing unit plays important roles in cell organization, chromosome segregation, and cancer development. However, little is known about the structure of the linker. Here, we show by stimulated emission depletion microscopy that the centrosome linker consists of a vast network of repeating rootletin units with a C-Nap1 ring at centrioles as organizer and CEP68 as filament modulator. Rootletin filaments originating from the two centrosomes form a web-like, interdigitating filamentous network, explaining the flexible nature of the centrosome linker and the ability of the kinesin motor Eg5 to disrupt the linker function by force.
Metabolic division of labor in microbial systems
Authors: Tsoi Ryan , Wu Feilun , Zhang Carolyn , Bewick Sharon , Karig David , You Lingchong 
Published: February 2018

SignificanceIf contained in a single population a complex metabolic pathway can impose a burden on the host, decreasing the system’s overall productivity. This limitation can be overcome by division of labor (DOL), where distinct populations perform different steps of the pathway, thus reducing the burden on each population. By compartmentalizing reactions, however, DOL reduces their efficiency by introducing a transport barrier for metabolites and enzymes. It remains unclear how the trade-off between reducing burden and decreasing reaction efficiency dictates the potential benefit of DOL. Through the analysis of different metabolic pathways we derive a general criterion establishing when DOL outperforms a single population. Our results can guide rational engineering of metabolic pathways and provide insights into operation of natural pathways.
Three-dimensional virtual histology enabled through cytoplasm-specific X-ray stain for microscopic and nanoscopic computed tomography
Authors: Busse Madleen , Müller Mark , Kimm Melanie A. , Ferstl Simone , Allner Sebastian , Achterhold Klaus , Herzen Julia , Pfeiffer Franz 
Published: February 2018

Significance
Three-dimensional histology of soft-tissue samples has proven to provide crucial benefits for the understanding of tissue structure. Nevertheless, the low attenuation of soft tissue has impaired the use of computed tomography (CT) as a tool for the nondestructive and 3D visualization of external and internal structural details. We present a cytoplasm-specific staining method tailored for X-ray CT that enables a routine and efficient 3D volume screening at high resolutions. Our technique is fully compatible with conventional histology and allows further histological investigations, as demonstrated for a mouse kidney. The comparative analysis of our CT data with conventional 2D histology highlights the future applicability of the cytoplasm-specific X-ray staining method for modern histological and histopathological investigations using laboratory X-ray CT devices.
Within- and across-trial dynamics of human EEG reveal cooperative interplay between reinforcement learning and working memory
Authors: Collins Anne G. E. , Frank Michael J. 
Published: February 2018

Significance
A major factor that improves learning in artificial agents is the use of multiple algorithms in parallel to benefit from their complementary strengths across different environments. The human brain performs a similar optimization, balancing the use of resource-intensive but immediately accessible information in working memory and a more reliable slow but steady reinforcement learning to build habits. These parallel computations are evident in neural signal dynamics that unfold across both short- and long-term time scales, which reveal that the two processes compete for decisions but cooperate for learning. These findings further our understanding of human learning and may inspire better artificial learners.
Bacmeta: simulator for genomic evolution in bacterial metapopulations
Authors: Sipola Aleksi , Marttinen Pekka , Corander Jukka 
Published: February 2018

Abstract

Summary
The advent of genomic data from densely sampled bacterial populations has created a need for flexible simulators by which models and hypotheses can be efficiently investigated in the light of empirical observations. Bacmeta provides fast stochastic simulation of neutral evolution within a large collection of interconnected bacterial populations with completely adjustable connectivity network. Stochastic events of mutations, recombinations, insertions/deletions, migrations and micro-epidemics can be simulated in discrete non-overlapping generations with a Wright–Fisher model that operates on explicit sequence data of any desired genome length. Each model component, including locus, bacterial strain, population and ultimately the whole metapopulation, is efficiently simulated using C++ objects and detailed metadata from each level can be acquired. The software can be executed in a cluster environment using simple textual input files, enabling, e.g. large-scale simulations and likelihood-free inference.

Availability and implementation
Bacmeta is implemented with C++ for Linux, Mac and Windows. It is available at https://bitbucket.org/aleksisipola/bacmeta under the BSD 3-clause license.

Supplementary information
Supplementary data are available at Bioinformatics online.
PennDiff: detecting differential alternative splicing and transcription by RNA sequencing
Authors: Hu Yu , Lin Jennie , Hu Jian , Hu Gang , Wang Kui , Zhang Hanrui , Reilly Muredach P , Li Mingyao 
Published: February 2018

Abstract

Motivation
Alternative splicing and alternative transcription are a major mechanism for generating transcriptome diversity. Differential alternative splicing and transcription (DAST), which describe different usage of transcript isoforms across different conditions, can complement differential expression in characterizing gene regulation. However, the analysis of DAST is challenging because only a small fraction of RNA-seq reads is informative for isoforms. Several methods have been developed to detect exon-based and gene-based DAST, but they suffer from power loss for genes with many isoforms.

Results
We present PennDiff, a novel statistical method that makes use of information on gene structures and pre-estimated isoform relative abundances, to detect DAST from RNA-seq data. PennDiff has several advantages. First, grouping exons avoids multiple testing for ‘exons’ originated from the same isoform(s). Second, it utilizes all available reads in exon-inclusion level estimation, which is different from methods that only use junction reads. Third, collapsing isoforms sharing the same alternative exons reduces the impact of isoform expression estimation uncertainty. PennDiff is able to detect DAST at both exon and gene levels, thus offering more flexibility than existing methods. Simulations and analysis of a real RNA-seq dataset indicate that PennDiff has well-controlled type I error rate, and is more powerful than existing methods including DEXSeq, rMATS, Cuffdiff, IUTA and SplicingCompass. As the popularity of RNA-seq continues to grow, we expect PennDiff to be useful for diverse transcriptomics studies.

Availability and implementation
PennDiff source code and user guide is freely available for download at https://github.com/tigerhu15/PennDiff.

Supplementary information
Supplementary data are available at Bioinformatics online.
Age Differences in Beliefs About Emotion Regulation Strategies
Authors: Livingstone Kimberly M , Castro Vanessa L , Isaacowitz Derek M 
Published: February 2018

AbstractObjectivesAge shifts in emotion regulation may be rooted in beliefs about different strategies. We test whether there are age differences in the beliefs people hold about specific emotion regulation strategies derived from the process model of emotion regulation and whether profiles of emotion beliefs vary by age.MethodAn adult life-span sample (N = 557) sorted 13 emotion regulation strategies either by (a) how effective the strategies would be or (b) how likely they would be to use them, in 15 negative emotion-eliciting situations.ResultsYounger adults ranked attentional and cognitive distraction more effective than older adults, and preferred avoidance, distraction, and rumination more (and attentional deployment less) than middle-aged and older adults. Latent profile analysis on preferences identified three distinct strategy profiles: Classically adaptive regulators preferred a variety of strategies; situation modifiers showed strong preferences for changing situations; a small percentage of people preferred avoidance and rumination. Middle-aged and older adults were more likely than younger adults to be classically adaptive regulators (as opposed to situation modifiers or avoiders/ruminators).DiscussionThese findings provide insight into the reasons people of different ages may select and implement different emotion regulation strategies, which may influence their emotional well-being.
Curiosity, interdisciplinarity, and giving back†
Authors: Ommer Rosemary E 
Published: February 2018

Abstract
The pursuit of interdisciplinarity in the marine sciences is at last beginning to come into its own, but the kind of interdisciplinarity that bridges the social, human, health, and natural science realms remains rare. This article traces the evolution of my own history of interdisciplinarity from its early days when I worked in two disciplines, to the present when I have worked with many others to bring together the natural sciences, social sciences, humanities, and earth/ocean sciences in large projects that illuminate the interconnectedness of all these parts of knowledge acquisition. In the process, I have broadened my intellectual vision both in scope and scale, uncovering the many ways in which, quite pragmatically, the very local and the international are more tightly interconnected than is often realized, with all the implications for fisheries governance that that implies. This, then, is both a story and, I hope, a pathway to a rewarding way for young and middle-career fisheries scholars to pursue their research.
Word of Mouth versus Word of Mouse: Speaking about a Brand Connects You to It More Than Writing Does
Authors: Shen Hao , Sengupta Jaideep 
Published: February 2018

AbstractThis research merges insights from the communications literature with that on the self-brand connection to examine a novel question: how does speaking versus writing about a liked brand influence the communicator’s own later reactions to that brand? Our conceptualization argues that because oral communication involves a greater focus on social interaction with the communication recipient than does written communication, oral communicators are more likely to express self-related thoughts than are writers, thereby increasing their self-brand connection (SBC). We also assess the implications of this conceptualization, including the identification of theoretically derived boundary conditions for the speech/writing difference, and the downstream effects of heightened SBC. Results from five studies provide support for our predictions, informing both the basic literature on communications, and the body of work on consumer word of mouth.
‘The Desert is Our Neighbour’: A Postcolonial Feminist Ethic of Narrative Encounter in Helen Oyeyemi’s Mr Fox
Authors: Radford CL Wren 
Published: February 2018

Abstract
Helen Oyeyemi’s Mr Fox rewrites gothic and fairytale tropes to expose patriarchal and colonial lines in sand encoded in fiction that legitimise the subjugation of women. Drawing on the work of Mayra Rivera, Sara Ahmed, and Kamala Visweswaran, this article argues that Oyeyemi’s work enacts a postcolonial feminist ethic of encounter that foregrounds and challenges gendered and colonial power relations. The article examines Oyeyemi’s metafictive storytelling, her use and critique of feminist revisioning and voicing, and genre play as strategies that call into question processes of representation and meaning-making in encountering others.
The strong grip of childhood conditions in older Europeans
Authors: Tampubolon Gindo , Fajarini Maria 
Published: February 2018

AbstractAmong older Europeans grip strength has been found to be marked by a disadvantaged adulthood. Across the Channel, among older Britons gait speed as another measure of physical function has been found to be marked by disadvantaged childhood. Using the Survey of Health, Ageing, and Retirement in Europe (2004-2013), we studied whether childhood poverty led to Europeans aged 50 to 104 years having a weaker grip. We then drew their trajectories of repeatedly measured grip strength to discern a steeper decline among the childhood poor. Retrospective childhood poverty some four to nine decades in the past was treated as a latent construct following the above literature; attrition during repeated measurements is handled using inverse proportional to attrition weighting. The data showed the childhood poor to have a weaker grip for half a century in later life. However, they do not show a steeper decline. Most important, by contributing to levels of grip strength in later life, adult condition holds the potential to shape the strong and long arm of childhood condition. The results are another impetus to eliminate childhood poverty to ensure healthy ageing Europeans.
Dissociable effects of prediction and integration during language comprehension: Evidence from a large-scale study using brain potentials
Authors: Nieuwland Mante S. , Barr Dale J. , Bartolozzi Federica , Busch-Moreno Simon , Darley Emily , Donaldson David I. , Ferguson Heather J. , Fu Xiao , Heyselaar Evelien , Huettig Falk , Husband E. Matthew , Ito Aine , Kazanina Nina , Kogan Vita , Kohút Zdenko , Kulakova Eugenia , Mézière Diane , Politzer-Ahles Stephen , Rousselet Guillaume , Rueschemeyer Shirley-Ann , Segaert Katrien , Tuomainen Jyrki , Wolfsthurn Sarah Von Grebmer Zu 
Published: February 2018

AbstractComposing sentence meaning is easier for predictable words than for unpredictable words. Are predictable words genuinely predicted, or simply more plausible and therefore easier to integrate with sentence context? We addressed this persistent and fundamental question using data from a recent, large-scale (N= 334) replication study, by investigating the effects of word predictability and sentence plausibility on the N400, the brain’s electrophysiological index of semantic processing. A spatiotemporally fine-grained mixed effects multiple regression analysis revealed overlapping effects of predictability and plausibility on the N400, albeit with distinct spatiotemporal profiles. Our results challenge the view that the predictability-dependent N400 reflects the effects ofeitherpredictionorintegration, and suggest that semantic facilitation of predictable words arises from a cascade of processes that activate and integrate word meaning with context into a sentence-level meaning.
Characterizing higher order structures of chromatin in human cells
Authors: Schwartz Uwe , Németh Attila , Diermeier Sarah , Exler Josef , Hansch Stefan , Maldonado Rodrigo , Heizinger Leonhard , Merkl Rainer , Läengst Gernot 
Published: February 2018

AbstractPackaging of DNA into chromatin regulates DNA accessibility and, consequently, all DNA-dependent processes, such as transcription, recombination, repair, and replication. The nucleosome is the basic packaging unit of DNA forming arrays that are suggested, by biochemical studies, to fold hierarchically into ordered higher-order structures of chromatin. This defined organization of chromatin has been recently questioned using microscopy techniques, proposing a rather irregular structure. To gain more insight into the principles of chromatin organization, we applied an in situ differential MNase-seq strategy and analyzed in silico the results of complete and partial digestions of human chromatin. We investigated whether different levels of chromatin packaging exist in the cell. Thus, we assessed the accessibility of chromatin within distinct domains of kb to Mb genomic regions by utilizing statistical data analyses and computer modelling. We found no difference in the degree of compaction between domains of euchromatin and heterochromatin or between other sequence and epigenomic features of chromatin. Thus, our data suggests the absence of differentially compacted domains of higher-order structures of chromatin. Moreover, we identified only local structural changes, with individual hyper-accessible nucleosomes surrounding regulatory elements, such as enhancers and transcription start sites. The regulatory sites per se are occupied with structurally altered nucleosomes, exhibiting increased MNase sensitivity. Our findings provide biochemical evidence that supports an irregular model of large-scale chromatin organization.