bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socio-environmental rights and the riddle of history
Authors: Gilbert Bruce 
Published: December 2018

Abstract: Broadly speaking, this paper is about the relationship of the human rights tradition to substantive issues of social justice, including class exploitation and environmental destruction. These themes I take to be of global concern, but I will examine them today as they arise from conflicts and struggles situated in Brazil. The key to the argument is to show that the human rights tradition recognizes necessary features of self-determination, and that claims for socio-environmental rights in Brazil and elsewhere derive their legitimacy from the same kind of argument that justifies individual rights, such as the 1948 United Nations Declaration, and collective rights, such as the International Covenant on Economic, Social and Cultural Rights of 1966 and the United Nations Declaration of the Rights of Indigenous Peoples of 2007. That is, I will try to show that individual, collective and socio-environmental rights are each necessary conditions but, on their own, insufficient conditions for the possibility of self-determination. The need for such rights emerges in the history of the struggle for justice. This this paper will also defend the claim that the universality of rights necessarily emerges from the historicity of social life and solves what Marx calls the “riddle of history.”
Keywords : Socio-enviromental rights; riddle of history.

Resumo: De um modo geral, este artigo trata da relação da tradição dos direitos humanos com questões substantivas de justiça social, incluindo a exploração de classes e a destruição ambiental. Esses temas são de interesse global, mas vou examiná-los hoje, pois eles surgem de conflitos e lutas no Brasil. A chave do argumento é mostrar que a tradição dos direitos humanos reconhece as características necessárias à autodeterminação, e que as reivindicações por direitos socioambientais no Brasil e em outros lugares derivam sua legitimidade do mesmo tipo de argumento que justifica os direitos individuais, como o Declaração das Nações Unidas de 1948, e direitos coletivos, como o Pacto Internacional sobre Direitos Econômicos, Sociais e Culturais de 1966 e a Declaração dos Direitos dos Povos Indígenas das Nações Unidas de 2007. Ou seja, tentarei mostrar que os direitos individuais, coletivos e Direitos socioambientais são, cada um, condições necessárias, mas, por si só, condições insuficientes para a possibilidade de autodeterminação. A necessidade de tais direitos surge na história da luta pela justiça. Este artigo também defenderá a afirmação de que a universalidade dos direitos surge necessariamente da historicidade da vida social e resolve o que Marx chama de "enigma da história".
ORGANIZAÇÕES EM REDE E TEORIA DA ESTRUTURAÇÃO: O CASO DE UMA REDE COLABORATIVA EM FORMAÇÃO
Authors: Ramos Schirlei Stock , Bobsin Debora 
Published: December 2018

Este estudo de caso investigou as motivações para a formação de uma Rede Colaborativa, suas bases estruturantes, e as influências dessa Rede no contexto local, destacando o papel, na sociedade, das redes colaborativas como estratégias sociocriativas capazes de promover a Inovação Social (IS). A partir dessas reflexões, esta pesquisa destaca como a adoção de redes de colaboração influencia a IS?A relevância deste estudo é abrir um espaço de reflexão multidisciplinar, articulando bases teóricas da Teoria da Estruturação (TE) e da IS. Buscou-se trazer para a centralidade do debate o papel dos agentes e dos processos sociocriativos no desenvolvimento local. Como resultado das discussões, emerge o poder de agência. Esse poder identificado na integração social da Rede, apresentou como pressupostos legitimadores construtos relacionados à memória, identidade e representação de elementos culturais intangíveis vinculados tanto a história cultural local quanto aos os objetivos finalísticos da Rede. É necessário ainda esclarecer que para a TE, lente teórica escolhida para as analises, o poder de agência não é experiência individual do ator, nem qualquer forma de totalidade social e sim “práticas sociais ordenadas no tempo e espaço” (GIDDENS,2009). Sugere-se como estudos futuros a investigação sobre o nível de consciência desses agentes sobre o poder de agência que detêm, e de como essa apropriação teórico-empírica poderia influenciar o comportamento dos agentes para maximizar o desempenho da Rede em promover a IS.
Ellipse packing in 2D cell tessellation: A theoretical explanation for Lewis’s law and Aboav-Weaire’s law
Authors: Xu Kai 
Published: December 2018

Background: To date, the theoretical bases of Lewis’s law and Aboav-Weaire’s law are still unclear.
Methods: Software R with package Conicfit was used to fit ellipses based on geometric parameters of polygonal cells of red alga Pyropia haitanensis.
Results: The average form deviation of vertexes from the fitted ellipse was 0±3.1 % (8,291 vertices in 1375 cells were examined). Area of the polygonal cell was 0.9±0.1 times of area of the ellipse’s maximal inscribed polygon (EMIP). These results indicated that the polygonal cells can be considered as ellipse’s inscribed polygons (EIPs) and tended to form EMIPs. This phenomenon was named as ellipse packing. Then, an improved relation of Lewis’s law for a n-edged cell was derived
\[cell\ area=0.5nab\sin(\frac{2\pi}{n})(1-\frac{3}{n^2})\]
where, a and b are the semi-major axis and the semi-minor axis of fitted ellipse, respectively. This study also improved the relation of Aboav-Weaire’s law
\[number\ of\ neighboring\ cells=6+\frac{6-n}{n}(\frac{a}{b}+\frac{3}{n^2})\]
Conclusions: Ellipse packing is a short-range order which places restrictions on the direction of cell division and the turning angles of cell edges. The ellipse packing requires allometric growth of cell edges. Lewis’s law describes the effect of deformation from EMIP to EIP on area. Aboav-Weaire’s law mainly reflects the effect of deformation from circle to ellipse on number of neighboring cells, and the deformation from EMIP to EIP has only a minor effect. The results of this study could help to simulate the dynamics of cell topology during growth.
Stress among on-duty firefighters: an ambulatory assessment study
Authors: Rodrigues Susana , Paiva Joana S. , Dias Duarte , Cunha João Paulo S. 
Published: December 2018

Background
Stress at work has been broadly acknowledged as a worldwide problem and has been the focus of concern for many researchers. Firefighting, in particular, is frequently reported as a highly stressful occupation. In order to investigate firefighters’ occupational health in terms of stress events, perceptions, symptoms, and physiological reactions under real-world conditions, an ambulatory assessment protocol was developed.

Methods
Seventeen firefighters’ cardiac signal was continuously monitored during an average of three shifts within a working week with medical clinically certified equipment (VitalJacket®), which allows for continuous electrocardiogram (ECG) and actigraphy measurement. Psychological data were collected with a software application running on smartphones, collecting potential stressful events, stress symptoms, and stress appraisal.

Results
A total of 450.56 h of medical-quality ECG were collected, and heart rate variability (HRV) analysis was performed. Findings suggest that although ‘fire’ situations are more common, ‘accidents’ are more stressful. Additionally, firefighters showed high levels of physiological stress (based on AVNN and LF/HF HRV metrics) when compared to normative healthy population values that may not be diagnosed using merely self-reports.

Discussion
The proposed ambulatory study seems to be useful for the monitoring of stress levels and its potential impact on health of first responders. Additionally, it could also be an important tool for the design and implementation of efficient interventions and informed management resolutions in real time. Potential applications of this research include the development of quantified occupational health (qOHealth) devices for real life monitoring of emergency personnel stress reactions.
Circular RNA profiling identifies circADAMTS13 as a miR‐484 sponge which suppresses cell proliferation in hepatocellular carcinoma
Authors: Qiu Liman , Huang Yanbing , Li Zhenli , Dong Xiuqing , Chen Geng , Xu Haipo , Zeng Yongyi , Cai Zhixiong , Liu Xiaolong , Liu Jingfeng 
Published: December 2018

Circular RNA (circRNA) can participate in various biological processes, including tumorigenesis, through their microRNA response elements. Alterations in circRNA profiles during hepatocellular carcinoma (HCC) progression and their clinical significance remain unclear. Here, we present extensive analysis of circRNA profiles in tumor and matched peritumor tissues collected from 10 HCC patients, conducted to identify circRNA related to HCC progression. A total of 42 dysregulated circRNA (38 down‐regulated and 4 up‐regulated) were identified in HCC tumor tissues compared with matched peritumor tissues, revealing the heterogeneity of circRNA profiles in HCC. CircADAMTS13, derived from Exon 13–14 of the ADAMTS13 gene, was significantly downregulated in HCC tumor tissues. Furthermore, clinicopathological analysis revealed that up‐regulation of circADAMTS13 was negatively associated with tumor size but positively associated with prognosis. In addition, overexpression of circADAMTS13 could markedly inhibit HCC cell proliferation in vitro. Bioinformatic analysis and luciferase reporter assays further revealed that circADAMTS13 directly interacts with microRNA (miR)‐484. Rescue experiments showed that miR‐484 mimics can reverse the tumor‐suppressing roles of circADAMTS13 in HCC. Therefore, our results demonstrated that circADAMTS13 can serve as a tumor suppressor during HCC progression via the functional pathway of sponging miR‐484.
Mass spectrometry‐based analysis of macromolecular complexes ofStaphylococcus aureusuracil‐DNA glycosylase and its inhibitor reveals specific variations due to naturally occurring mutations
Authors: Papp‐Kádár Veronika , Balázs Zoltán , Vékey Károly , Ozohanics Olivér , Vértessy Beáta G. 
Published: December 2018

The base excision repair pathway plays an important role in correcting damage induced by either physiological or external effects. This repair pathway removes incorrect bases from theDNA. The uracil base is among the most frequently occurring erroneous bases inDNA, and is cut out from the phosphodiester backbone via the catalytic action of uracil‐DNAglycosylase. Uracil excision repair is an evolutionarily highly conserved pathway and can be specifically inhibited by a protein inhibitor of uracil‐DNAglycosylase. Interestingly, both uracil‐DNAglycosylase (Staphylococcus aureusuracil‐DNAglycosylase;SAUDG) and its inhibitor (S. aureusuracil‐DNAglycosylase inhibitor;SAUGI) are present in the staphylococcal cell. The interaction of these two proteins effectively decreases the efficiency of uracil‐DNAexcision repair. The physiological relevance of this complexation has not yet been addressed in detailed; however, numerous mutations have been identified withinSAUGI. Here, we investigated whether these mutations drastically perturb the interaction withSAUDG. To perform quantitative analysis of the macromolecular interactions, we applied native mass spectrometry and demonstrated that this is a highly efficient and specific method for determination of dissociation constants. Our results indicate that several naturally occurring mutations ofSAUGIdo indeed lead to appreciable changes in the dissociation constants for complex formation. However, all of theseKdvalues remain in the nanomolar range and therefore the association of these two proteins is preserved. We conclude that complexation is most likely preserved even with the naturally occurring mutant uracil‐DNAglycosylase inhibitor proteins.
Evaluation of plan quality and treatment efficiency for single‐isocenter/two‐lesion lung stereotactic body radiation therapy
Authors: Sanford Lana , Molloy Janelle , Kumar Sameera , Randall Marcus , McGarry Ronald , Pokhrel Damodar 
Published: December 2018

AbstractPurpose/objectivesTo evaluate the plan quality and treatment delivery efficiency of single‐isocenter/two‐lesions volumetric modulated arc therapy (VMAT) lung stereotactic body radiation therapy (SBRT).Materials/methodsEight consecutive patients with two peripherally located early stage nonsmall‐cell‐lung cancer (NSCLC) lung lesions underwent single‐isocenter highly conformal noncoplanar VMAT SBRT treatment in our institution. A single‐isocenter was placed between the two lesions. Doses were 54 or 50 Gy in 3 and 5 fractions respectively. Patients were treated every other day. Plans were calculated in Eclipse with AcurosXB algorithm and normalized to at least 95% of the planning target volume (PTV) receiving 100% of the prescribed dose. For comparison, two‐isocenter plans (isocenter placed centrally in each target) were retrospectively created. Conformity indices (CIs), heterogeneity index (HI), gradient index (GI), gradient distance (GD), and D2cm were calculated. The normal lung V5, V10, V20, mean lung dose (MLD) and other organs at risk (OARs) doses were evaluated. Total number of monitor units (MUs), beam‐on time, and patient‐specific quality assurance (QA) results were recorded.ResultsThe mean isocenter to tumor distance was 6.7 ± 2.3 cm. The mean combined PTV was 44.0 ± 23.4 cc. There was no clinically significant difference in CI, HI, GD, GI, D2cm, and V20 including most of the OARs between single‐isocenter and two‐isocenter lung SBRT plans, evaluated per RTOG guidelines. However, for single‐isocenter plans as the distance between the lesions increased, the V5, V10, and MLD increased, marginally. The total number of MUs and beam‐on time was reduced by a factor of 1.5 for a single‐isocenter plan compared to a two‐isocenter plan. The single‐isocenter/two‐lesions VMAT lung SBRT QA plans demonstrated an accurate dose delivery of 98.1 ± 3.2% for clinical gamma passing rate of 3%/3 mm.ConclusionThe SBRT treatment of two peripherally located lung lesions with a centrally placed single‐isocenter was dosimetrically equivalent to two‐isocenter plans. Faster treatment delivery for single‐isocenter treatment can improve patient compliance and reduce the amount of intrafraction motion errors for well‐suited patients.
US consumer reactions to China's Shuanghui acquisition of Smithfield Foods and its neural basis
Authors: Zhang Yu Yvette , Palma Marco A. , Jin Shaosheng , Yuan Xiaotong 
Published: December 2018

AbstractThe $4.7 billion acquisition of Smithfield Foods by China's Shuanghui International (now WH Group) marks the largest Chinese takeover of a US company in history. Using electroencephalography along with an incentive compatible willingness‐to‐pay (WTP) elicitation mechanism, our study provides neural based evidence that the Shuanghui–Smithfield acquisition lowered consumers' preference for the Smithfield brand, but increased it for the Chinese brand. Consumers' neural preference for American brands increased after learning about the acquisition, implying a positive spillover effect to US brands in the US market. We also find that, after learning that an item is a product of the United States, consumers' neural preference decreased although their willingness‐to‐pay increased, consistent with some empirical reports that many US consumers prefer to purchase cheaper products made abroad rather than products of the United States with higher prices.
Chinese consumer preferences for fresh produce: Interaction between food safety labels and brands
Authors: Yin Shijiu , Hu Wuyang , Chen Yusheng , Han Fei , Wang Yiqin , Chen Mo 
Published: December 2018

AbstractIn this study, 938 consumers in China's Shandong Province were surveyed for their preferences for tomatoes in a real choice experiment varying in three product attributes: food safety label, brand, and price. Using a mixed logit model, results revealed that consumer willingness to pay for organic tomatoes was higher than that for tomatoes labeled as Green or Generally Regarded as Safe (GRS). With regard to brands, consumers prefer brands affiliated with proprietary enterprises over brands held by agricultural cooperatives. The interactions between organic label and brands as well as that between Green label and brands were significantly positive suggesting synergy between these labels and brands. Conversely, the interaction between the GRS label and brands was insignificant. The conclusions should not only aid Chinese policy makers in developing its food safety certification strategies but also provide references for producers and certification bodies for their business decision‐making.
Getting into Shape: Limb Bone Strength in PerinatalLemur cattaandPropithecus coquereli
Authors: Young Jesse W. , Jankord Kathryn , Saunders Marnie M. , Smith Timothy D. 
Published: December 2018

ABSTRACTFunctional studies of skeletal anatomy are predicated on the fundamental assumption that form will follow function. For instance, previous studies have shown that the femora of specialized leaping primates are more robust than those of more generalized primate quadrupeds. Are such differences solely a plastic response to differential loading patterns during postnatal life, or might they also reflect more canalized developmental mechanisms present at birth? Here, we show that perinatalLemur catta, an arboreal/terrestrial quadruped, have less robust femora than perinatalPropithecus coquereli, a closely related species specialized for vertical clinging and leaping (a highly unusual locomotor mode in which the hindlimbs are used to launch the animal between vertical tree trunks). These results suggest that functional differences in long bone cross‐sectional dimensions are manifest at birth, belying simple interpretations of adult postcranial form as a direct record of loading patterns during postnatal life. Despite these significant differences in bone robusticity, we find that hindlimb bone mineralization, material properties, and measures of whole‐bone strength generally overlap in perinatalL. cattaandP. coquereli, indicating little differentiation in postcranial maturity at birth despite known differences in the pace of craniodental development between the species. In a broader perspective, our results likely reflect evolution acting during prenatal ontogeny. Even though primates are notable for relatively prolonged gestation and postnatal parental care, neonates are not buffered from selection, perhaps especially in the unpredictable and volatile environment of Madagascar. Anat Rec, 2018. © 2018 Wiley Periodicals, Inc. Anat Rec, 303:250–264, 2020. © 2018 American Association for Anatomy
Bio‐orthogonal AIE Dots Based on Polyyne‐Bridged Red‐emissive AIEgen for Tumor Metabolic Labeling and Targeted Imaging
Authors: Zhang Pengfei , Jiang Tao , Li Yuanyuan , Zhao Zheng , Gong Ping , Cai Lintao , Kwok Ryan T. K. , Lam Jacky Wing Yip , Gu Xinggui , Tang Ben Zhong 
Published: December 2018

AbstractIn this work, we aim to develop cancer cell‐targeting AIE dots based on a polyyne‐bridged red‐emissive AIEgen, 2TPE‐4E, through the combination of metabolic engineering and bio‐orthogonal reactions. Azide groups on a tumor were efficiently produced by intravenous injection of Ac4ManNAz and glycol‐metabolic engineering. These bio‐orthogonal azide groups could facilitate the specific targeting of DBCO‐AIE dots to the tumor cells undergoing metal‐free click reaction in vivo. The efficiency of this targeting strategy could be further improved with the development of new bio‐orthogonal chemical groups with higher reactivity and a large amount of AIEgens could be delivered to the tumor for diagnosis.
Amber suppression coupled with inducible surface display identifies cells with high recombinant protein productivity
Authors: Chakrabarti Lina , Zhuang Li , Roy Gargi , Bowen Michael A. , Dall’Acqua William F. , Hawley‐Nelson Pam , Marelli Marcello 
Published: December 2018

AbstractCell line development (CLD) for biotherapeutics is a time‐ and resource‐intensive process requiring the isolation and screening of large numbers of clones to identify high producers. Novel methods aimed at enhancing cell line screening efficiency using markers predictive of productivity early in the CLD process are needed to reliably generate high‐yielding cell lines. To enable efficient and selective isolation of antibody expressing Chinese hamster ovary cells by fluorescence‐activated cell sorting, we developed a strategy for the expression of antibodies containing a switchable membrane‐associated domain to anchor an antibody to the membrane of the expressing cell. The switchable nature of the membrane domain is governed by the function of an orthogonal aminoacyl transfer RNA synthetase/tRNApyl pair, which directs a nonnatural amino acid (nnAA) to an amber codon encoded between the antibody and the membrane anchor. The process is “switchable” in response to nnAA in the medium, enabling a rapid transition between the surface display and secretion. We demonstrate that the level of cell surface display correlates with productivity and provides a method for enriching phenotypically stable high‐producer cells. The strategy provides a means for selecting high‐producing cells with potential applications to multiple biotherapeutic protein formats.
Barriers and strategies: Implementing active learning in biomedical science lectures
Authors: Kim Alice M. , Speed Caroline J. , Macaulay Janet O. 
Published: December 2018

AbstractThe traditional teaching style in higher education is didactic. However, the current literature states that student learning improves when they are active players in the process, triggering the move to implement active learning within the curriculum. In accordance, Monash University (an Australian research‐intensive university) introduced the “Better Teaching Better Learning” agenda to deliver a more student‐centered learning experience but its implementation has been inconsistent across its different schools. Interviews and an online survey were conducted to evaluate the teaching practices in lectures of Biomedical Science academics, identify barriers preventing them from implementing active learning in their teaching, and identify possible strategies to overcome said barriers. The two main teaching groups use a variety of teaching styles in lectures, with education‐focused academics employing more active learning practices. Many academics were in the process of changing their teaching style, mainly to improve the overall student learning experience. However, complex barriers prevent them from doing so. Possible strategies were identified that would help academics adopt a more student‐centered teaching style. © 2018 International Union of Biochemistry and Molecular Biology, 47(1):29–40, 2018.
Social capital: Implications for neurology
Authors: Reyes Saúl , Giovannoni Gavin , Thomson Alison 
Published: December 2018

AbstractSocial capital (SC) is a broad term that encompasses the many resources derived from social connections. The contemporary study of SC in public health has deep roots in the related fields of sociology, economics, and politics. Its multidisciplinary nature and the varying potential ways it could affect individuals have resulted in different but overlapping models to approach SC in the health field. There are currently no standardized measures of SC, and even more challenging its impact on health outcomes seems to vary according to the level of analysis. Despite the accumulating evidence that supports a protective effect of SC on mental and physical health, and mortality, not enough attention has been paid to the potential drawbacks of SC. The role of SC in neurological disease is just beginning to be explored. Concerted efforts are needed to ensure that empirical evidence on SC could be properly translated into interventions for health‐promoting purposes. In this paper, we review the current state of scientific knowledge on the subject of SC, with a focus on its application in the field of neurology.