bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Solanum neorickii introgression population providing a powerful complement to the extensively characterized Solanum pennellii population
Authors: Brog Yaacov Micha , Osorio Sonia , Yichie Yoav , Alseekh Saleh , Bensal Elad , Kochevenko Andriy , Zamir Dani , Fernie Alisdair R. 
Published: September 2018

Summary
We present a complementary resource for trait fine‐mapping in tomato to those based on the intra‐specific cross between cultivated tomato and the wild tomato species Solanum pennellii, which have been extensively used for quantitative genetics in tomato over the last 20 years. The current population of backcross inbred lines (BILs) is composed of 107 lines derived after three backcrosses of progeny of the wild species Solanum neorickii (LA2133) and cultivated tomato (cultivar TA209) and is freely available to the scientific community. These S. neorickii BILs were genotyped using the 10K SolCAP single nucleotide polymorphism chip, and 3111 polymorphic markers were used to map recombination break points relative to the physical map of Solanum lycopersicum. The BILs harbor on average 4.3 introgressions per line, with a mean introgression length of 34.7 Mbp, allowing partitioning of the genome into 340 bins and thereby facilitating rapid trait mapping. We demonstrate the power of using this resource in comparison with archival data from the S. pennellii resources by carrying out metabolic quantitative trait locus analysis following gas chromatography–mass spectrometry on fruits harvested from the S. neorickii BILs. The metabolic candidate genes phenylalanine ammonia‐lyase and cystathionine gamma‐lyase were then tested and validated in F2 populations and via agroinfiltration‐based overexpression in order to exemplify the fidelity of this method in identifying the genes that drive tomato metabolic phenotypes.
Anti‐D from alloimmunization versus RhIG: detective work in the blood bank and transfusion medicine services
Authors: Berry Debra , DiGuardo Margaret , Mo Yunchuan Delores , Wehrli Gay 
Published: September 2018

BACKGROUNDThe blood bank and transfusion medicine services (BBTMS) engages with electronic health records (EHRs), clinicians, and outside hospitals (OHs) to obtain comprehensive patient history to optimize care. Detection of anti‐D in a pregnant patient underscores this work. Differentiating passive anti‐D due to RhIG administration versus alloanti‐D affects clinical decision making. The objectives of this study were to identify the required steps, barriers, and outcomes of anti‐D investigations in obstetric patients.STUDY DESIGN AND METHODSThis retrospective case series reviewed nine pregnant patients over 24 months, for whom anti‐D was identified with no reported RhIG history. Six steps were performed to ascertain anti‐D history: 1) review the on‐site EHR; 2) contact the on‐site obstetrician, 3) review history from the automatic health information exchange (HIE) with OHs using the same EHR platform, 4) request information from OHs with a shared EHR platform and without automatic HIE, 5) contact the OH BBTMS, and 6) communicate with the outside ambulatory practice (OAP).RESULTSThe investigations revealed that eight of nine patients received RhIG before their presentation. Five patients received RhIG at an OH's emergency department and three at an OAP. One patient's history remained unknown after initial investigations; however, a subsequent sample unveiled a confounding alloantibody.CONCLUSIONIn the absence of a national HIE, continuity of care suffers through omission of critical information. Strategies to avoid confusing passive anti‐D and alloanti‐D include expanding HIE capabilities and use of patient identification cards with critical BBTMS information to include RhIG administration dates.
Generation of procoagulant collagen‐ and thrombin‐activated platelets in platelet concentrates derived from buffy coat: the role of processing, pathogen inactivation, and storage
Authors: Bertaggia Calderara Debora , Crettaz David , Aliotta Alessandro , Barelli Stefano , Tissot Jean‐Daniel , Prudent Michel , Alberio Lorenzo 
Published: September 2018

BACKGROUNDCollagen‐ and thrombin‐activated (COAT) platelets (PLTs), generated by dual‐agonist stimulation with collagen and thrombin (THR), enhance THR generation at the site of vessel wall injury. There is evidence that higher amounts of procoagulant COAT PLTs are associated with stroke, while a decreased ability to generate them is associated with bleeding diathesis. Our aim was to study PLT functions, particularly the ability to generate COAT PLTs, in PLT concentrates (PCs) from buffy coat. Thus, we investigated the effect of processing, pathogen inactivation treatment (amotosalen‐UVA), and PC storage.STUDY DESIGN AND METHODSTwo PCs from five donors each were pooled and split in two bags; one of them was pathogen inactivated and the other one was left untreated (n = 5). Flow cytometric analyses were performed immediately after PC preparation (Day 1) and thereafter on Days 2, 5, 7, and 9 in treated and untreated PCs to measure the reactivity of PLTs (CD62P and PAC‐1), the content and secretion of dense granule after stimulation with different agonists, and the percentage of COAT PLTs after dual stimulation with convulxin (agonist of the collagen receptor GPVI) and THR.RESULTSPreparation of PCs resulted in a significant decrease of COAT PLTs and in an impaired response to adenosine 5′‐diphosphate sodium (ADP). Storage further decreased ADP response. Minor differences were observed between untreated or amotosalen‐UVA–treated PCs.CONCLUSIONPreparation of PCs from buffy coats decreased the ability to generate COAT PLTs and impaired PLT response to ADP.
Examining Dutch disease across Australian regions
Authors: Shafiullah Muhammad , Selvanathan Saroja , Naranpanawa Athula , Chai Andreas 
Published: September 2018

AbstractThe recent mining boom represents one of the largest external shocks to the Australian economy in its post‐war history. Although most agree that it had a positive effect on the Australian economy as well as on people’s living standards, there is disagreement over the extent to which this boom has caused deindustrialisation and the so‐called Dutch disease in Australia. Our empirical findings support the presence of Dutch disease nationally for Australia using data for the period 1984–2013. Regionally, the results show that Dutch disease was concentrated mainly in the eastern and southern states of Australia—Victoria, Queensland, South Australia and Tasmania.
Long‐term culture and in vitro maturation of macroencapsulated adult and neonatal porcine islets
Authors: Mourad Nizar I. , Gianello Pierre 
Published: September 2018

AbstractEncapsulated porcine islets could be used to treat type I diabetes without necessitating severe immunosuppression. Islet survival and secretory function in the encapsulation device need to be preserved to ensure efficient insulin output in response to surrounding stimuli. In the present study, we evaluated stimulated insulin secretion from adult and neonatal pig islets seeded on an acellular collagen matrix and encapsulated in alginate during long‐term culture. Pig islets survived longer and secreted more insulin when cultured on acellular porcine dermis compared to human fascia. Islets from neonatal pigs could survive up to 33 weeks in vitro, and their insulin secretion increased during the first 5 weeks of culture in a beta‐cell maturation medium. In fact, by the 4th week of culture, insulin secretion from neonatal islets attained the same level as adult islets and even surpassed it by the 18th week. Our results show that in vitro maturation of encapsulated neonatal porcine islets is possible and can actually compensate the initial low insulin secretion from these islets while allowing enough time to perform complete functional and biosafety characterization of islets before transplantation.
Cryptic speciation yields remarkable mimics: A new genus of sea slugs that masquerade as toxic algae (Caulerpa spp.)
Authors: Krug Patrick J. , Wong Nur Leena W. S. , Medina Melanie R. , Gosliner Terrence M. , Valdés Ángel A. 
Published: September 2018

Abstract“Cryptic” can refer to species that match their background through camouflage or disruptive colouration, or in taxonomy to externally similar but unrecognized congeners. In adaptive resemblance, organisms resemble parts of a larger host animal or plant on which the mimic is highly cryptic. Mimetic lineages that radiate onto superficially similar hosts may contain cryptic species in both senses: taxa that are difficult to detect, and challenging for taxonomists to distinguish. Here, we describe a new genus and four species of herbivorous sea slugs (Gastropoda, Heterobranchia, Sacoglossa), including remarkable mimics of toxic green algae (Caulerpa spp.) on which the slugs feed. The long‐recognized Stiliger smaragdinus Baba 1949 is highly mimetic of “sea grapes” (Caulerpa racemosa‐lentillifera), but phylogenetic analyses of four genes indicated Stiliger was polyphyletic: the name‐bearing species grouped within Placida, whereas Caulerpa‐mimetic lineages were phylogenetically distinct. We erect the genus Sacoproteus gen. n. for S. smaragdinus (Baba 1949), and describe four new species: S. nishae sp. n. from the Indo‐Pacific, which mimics Caulerpa chemnitzia; Sacoproteus yhiae sp. n. and Sacoproteus browni sp. n. from southern Australia, which mimic Caulerpa cactoides and Caulerpa gemminata; and Sacoproteus thomasleei sp. n., a non‐mimetic west Pacific species that shared key features. Stiliger s.s. and Placida species show crypsis and aposematism but not host mimicry, although Stiliger spp. feeding on undefended algae may be Batesian mimics. Investigating the ecology and biogeography of Sacoproteus gen. n. will yield insight into how selection generates such extraordinary examples of adaptive resemblance in the marine realm.
Population structure and phylogenetic relationships of a new shallow‐water Antarctic phyllodocid annelid
Authors: Leiva Carlos , Riesgo Ana , Avila Conxita , Rouse Greg W. , Taboada Sergi 
Published: September 2018

AbstractShallow‐water polychaetes are abundant and diverse components of the Southern Ocean benthic communities, and although they have been widely studied, new species that are relatively common are still discovered. Here, we report the discovery of Pterocirrus giribeti sp. n., a new and abundant intertidal and upper‐subtidal Antarctic phyllodocid. To establish the phylogenetic relationships of the new species, we sequenced two nuclear (18S and 28S) and two mitochondrial (COI and 16S) markers. Although the phylogenetic relationships obtained for the family Phyllodocidae were not fully resolved, we assigned our new phyllodocid to the genus Pterocirrus based on both its phylogenetic position and its morphological characters. Using COI and 16S sequences of 126 and 118 individuals, respectively, from eight populations across the South Shetland Islands and the Antarctic Peninsula, we also investigated the genetic diversity and gene flow patterns of this new species. Our results suggested that all populations were panmictic, likely due to the presence of planktotrophic larvae allowing long‐distance dispersal. Interestingly, some genetic substructure was detected despite panmixis, and we identified a semipermeable barrier coinciding with an oceanic front produced by the intrusion into the Bransfield Strait of a tongue of water from the Weddell Sea. This front produced signatures of differentiation on populations at the tip of the West Antarctic Peninsula. Moreover, our results indicated a recent demographic expansion throughout the sampled area, in agreement with the “glacial refugium” hypothesis stated for other Antarctic shallow‐water invertebrates.
Trend Pembelajaran Menggunakan Multimedia Interaktif Dalam Bidang Pendidikan Teknikal : Satu Sorotan Literatur
Authors: Salsidu Siti Zulaidah , Azman Mohamed Nor Azhari , Pratama Hendri 
Published: September 2018

Technology is keeping pace with the progress of education in the country. The rapid development in information technology and computing indirectly change the education system in Malaysia. Teachersnowadays is not just teach by use of lime and speak orally, they are also exposed to the use of technology in teaching. This scenario shows the rapid usage of computers in teaching and learning process (P&P). Study was intended to show the trend of learning using Interactive Multimedia in Technical Education. These is the conceptual framework for the study. The purpose of this study was to examine the changing trendsof Multimedia Interactive Learning patterns of the usage of multimedia educational media specified in Technical Education between the years 1900-2013. The results for the perspective on the use of Interactive Multimedia is very helpful in the learning and teaching process in the school.
Development and evaluation of a novel Vital Signs Alert device for use in pregnancy in low-resource settings
Authors: Nathan Hannah L , Vousden Nicola , Lawley Elodie , de Greeff Annemarie , Hezelgrave Natasha L , Sloan Nicola , Tanna Nina , Goudar Shivaprasad S , Gidiri Muchabayiwa F , Sandall Jane , Chappell Lucy C , Shennan Andrew H 
Published: September 2018

ObjectivesHaemorrhage, hypertension, sepsis and abortion complications (often from haemorrhage or sepsis) contribute to 60% of all maternal deaths. Each is associated with vital signs (blood pressure (BP) and pulse) abnormalities, and the majority of deaths are preventable through simple and timely intervention. This paper presents the development and evaluation of the CRADLE Vital Signs Alert (VSA), an accurate, low-cost and easy-to-use device measuring BP and pulse with an integrated traffic light early warning system. The VSA was designed to be used by all cadres of healthcare providers for pregnant women in low-resource settings with the aim to prevent avoidable maternal mortality and morbidity.MethodsThe development and the mixed-methods clinical evaluation of the VSA are described.ResultsPreliminary fieldwork identified that introduction of BP devices to rural clinics improved antenatal surveillance of BP in pregnant women. The aesthetics of the integrated traffic light system were developed through iterative qualitative evaluation. The traffic lights trigger according to evidence-based vital sign thresholds in hypertension and haemodynamic compromise from haemorrhage and sepsis. The VSA can be reliably used as an auscultatory device, as well as its primary semiautomated function, and is suitable as a self-monitor used by pregnant women.ConclusionThe VSA is an accurate device incorporating an evidence-based traffic light early warning system. It is designed to ensure suitability for healthcare providers with limited training and may improve care for women in pregnancy, childbirth and in the postnatal period.
A pilot study assessing the spiritual, emotional, physical/environmental, and physiological needs of mechanically ventilated surgical intensive care unit patients via eye tracking devices, head nodding, and communication boards
Authors: Duffy Erin I , Garry Jonah , Talbot Lillian , Pasternak David , Flinn Ashley , Minardi Casey , Dookram Michele , Grant Kathleen , Fitzgerald Debbie , Rubano Jerry , Vosswinkel James , Jawa Randeep S 
Published: September 2018

BackgroundMechanically ventilated patients in the intensive care unit (ICU) are unable to communicate verbally. We sought to evaluate their needs via a communication board (CB) and a novel eye tracking device (ETD) that verbalizes selections made by gazing.MethodsThis was a pilot prospective study conducted in a tertiary care surgical ICU. Continuously mechanically ventilated adult surgical ICU patients with a Richmond Agitation-Sedation Scale score of −1 to +1, without cognitive impairment, were eligible. We asked patients four yes-or-no questions to assess basic needs regarding presence of pain, need for endotracheal suction, satisfactory room temperature, and position comfort. Patients were then asked if there was anything else that they wanted to communicate. All responses were confirmed by head nodding.ResultsThe median accuracy of the CB (100% (IQR 100%–100%)) for basic needs communication (yes/no questions) was comparable with that of the ETD (100% (IQR 68.8%–100%); p=0.14) in the 12 enrolled patients. Notably, 83% of patients desired to communicate additional information, ranging from spiritual (eg, desire for prayer/chaplain), emotional (eg, frustration, desire for comfort), physical/environmental (eg, television), to physiological (eg, thirst/hunger) needs.DiscussionThe majority of patients desired to communicate something other than basic needs. Unless specifically assessed via an assistive communication device (eg, CB or ETD), some of these other needs would have been difficult to discern.Level of evidenceIV therapeutic care/management.
A Simple but Quantifiable Approach to Dynamic Price Prediction in Ride-on-demand Services Leveraging Multi-source Urban Data
Authors: Guo Suiming , Chen Chao , Wang Jingyuan , Liu Yaxiao , Xu Ke , Zhang Daqing , Chiu Dah Ming 
Published: September 2018

Ride-on-demand (RoD) services such as Uber and Didi are becoming increasingly popular, and in these services dynamic prices play an important role in balancing the supply and demand to benefit both drivers and passengers. However, dynamic prices also create concerns. For passengers, the "unpredictable" prices sometimes prevent them from making quick decisions: one may wonder if it is possible to get a lower price if s/he chooses to wait a while. It is necessary to provide more information to them, and predicting the dynamic prices is a possible solution. For the transportation industry and policy makers, there are also concerns about the relationship between RoD services and their more traditional counterparts such as metro, bus, and taxi: whether they affect each other and how.
In this paper we tackle these two concerns by predicting the dynamic prices using multi-source urban data. Price prediction could help passengers understand whether they could get a lower price in neighboring locations or within a short time, thus alleviating their concerns. The prediction is based on urban data from multiple sources, including the RoD service itself, taxi service, public transportation, weather, the map of a city, etc. We train a simple linear regression model with high-dimensional composite features to perform the prediction. By combining simple basic features into composite features, we compensate for the loss of expressiveness in a linear model due to the lack of non-linearity. Additionally, the use of multi-source data and a linear model enables us to quantify and explain the relationship between multiple means of transportation by examining the weights of different features in the model. Our hope is that the study not only serves as an accurate prediction to make passengers more satisfied, but also sheds light on the concern about the relationship between different means of transportation for either the industry or policy makers.
CrowdProbe
Authors: Hong Hande , De Silva Girisha Durrel , Chan Mun Choon 
Published: September 2018

Devices with integrated Wi-Fi chips broadcast beacons for network connection management purposes. Such information can be captured with inexpensive monitors and used to extract user behavior. To understand the behavior of visitors, we deployed our passive monitoring system---CrowdProbe, in a multi-floor museum for six months. We used a Hidden Markov Models (HMM) based trajectory inference algorithm to infer crowd movement using more than 1.7 million opportunistically obtained probe request frames.
However, as more devices adopt schemes to randomize their MAC addresses in the passive probe session to protect user privacy, it becomes more difficult to track crowd and understand their behavior. In this paper, we try to make use of historical transition probability to reason about the movement of those randomized devices with spatial and temporal constraints. With CrowdProbe, we are able to achieve sufficient accuracy to understand the movement of visitors carrying devices with randomized MAC addresses.
SweepLoc
Authors: Li Mingkuan , Liu Ning , Niu Qun , Liu Chang , Chan S.-H. Gary , Gao Chengying 
Published: September 2018

Indoor localization based on visual landmarks has received much attention in commercial sites with rich features (e.g., shopping malls, museums) recently because landmarks are relatively stable over a long time. Prior arts often require a user to take multiple independent images around his/her location, and manually confirm shortlisted landmarks. The process is sophisticated, inconvenient, slow, unnatural and error-prone. To overcome these limitations, we propose SweepLoc, a novel, efficient and automatic video-based indoor localization system. SweepLoc mimics our natural scanning around to identify nearby landmarks in an unfamiliar site to localize.
In SweepLoc, a user simply takes a short video clip (about 6 to 8 seconds) of his/her surroundings by sweeping the camera. Using correlation and scene continuity between successive video frames, it automatically and efficiently selects key frames (where potential landmarks are centered) and subsequently reduces the decision error on landmarks. With identified landmarks, SweepLoc formulates an optimization problem to locate the user, taking compass noise and floor map constraint into account. We have implemented SweepLoc in Android platform. Our extensive experimental results in a food plaza and a premium mall demonstrate that SweepLoc is fast (less than 1 second to localize), and achieves substantially better accuracy as compared with the state-of-the-art approaches (reducing the localization error by 30%).
Cooperative Target Tracking and Signal Propagation Learning Using Mobile Sensors
Authors: Tan Jiajie , Wong Wangkit , Zhu Xinyu , Wu Hang , Chan S.-H. Gary 
Published: September 2018

Target tracking refers to positioning mobile objects over time. The targets may be hospital patients, park visitors, mall shoppers, warehouse assets, etc. We consider a novel cooperative system to track targets, where a target carries low-cost RF tag which not only beacons its ID, but also receives and rebroadcasts beacons of tags within a certain hop away. Mobile sensors, equipped with localization and communication modules, are used to capture and forward the beacons to a server to track the targets. Such multi-hop approach greatly extends the sensing range of the mobile sensors, or equivalently, the beaconing range of the tags, leading to cost-effective deployment.
We propose Mosent, a highly accurate multi-hop system using mobile sensors for target tracking. To account for complex signal propagation in different indoor and outdoor environment, we represent the received signal strength (RSS) matrix overcoming the assumption on propagation model. Given sensor locations, beacons detected by the sensors and RSS matrix, Mosent jointly considers temporal and spatial information to track targets using a modified particle filter. Mosent has an optional, independent and offline module to learn spatial signal propagation in terms of RSS matrix using cooperative mobile sensors equipped with beaconing transceivers. We have implemented Mosent and conducted extensive experiments. Our results show that Mosent achieves 4.37m and 9.46m tracking error in the campus and the shopping mall, respectively, which outperforms other state-of-the-art approaches with significantly lower tracking error (often by more than 30%).