bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turismo y desarrollo vitivinícola en espacios de montaña con “alta densidad patrimonial”
Authors: Baraja Rodríguez Eugenio , Herrero Luque Daniel , Martínez Arnáiz Marta , Plaza Gutiérrez Juan Ignacio 
Published: May 2019

El fomento del enoturismo se está convirtiendo en una estrategia cada vez más frecuente en las comarcas vitivinícolas del Duero que han consolidado su faceta productiva en torno a los vinos de calidad, y que ahora ponen en valor los elementos patrimoniales de unos paisajes vinculados al productivismo. Pero al tiempo, en los entornos más frágiles, en los espacios menos transformados y de alta concentración de bienes patrimoniales que los han posicionado como destinos turísticos, este sector está operando como palanca de reactivación y de inserción competitiva de unos viñedos cada vez más reconocidos y valorados. Para ilustrar este proceso, el artículo analiza la dinámica de unos viñedos cultivados en entornos de “alta densidad patrimonial”, la Sierra de Salamanca.
The promotion of wine tourism is becoming an increasingly frequent strategy in the Douro wine regions. They have consolidated their productivity around quality wines and now highlight the heritage elements of landscapes linked to production. However, at the same time, in the least transformed areas with fragile environments but a high concentration of heritage assets -that position them as tourist destinations-, this wine sector is acting as a stimulus in the revival and competitive conservation of vineyards, more and more valued and recognised in the landscape as a tourism generator. To illustrate this process, this paper analyses the dynamics of vineyards cultivated in environments with a high density of heritage elements such as the Sierra de Salamanca (Spain).
La capacidad de carga psicosocial del turista: instrumento de medición para el desarrollo sostenible en la turistificación de los cenotes
Authors: Blanco Gregory Rocío , Enseñat Soberanis Fernando , Mondragón Mejía Johnathan Alexander 
Published: May 2019

La capacidad de carga psicosocial ha demostrado ser un instrumento efectivo para establecer números máximos de personas que un turista está dispuesto a ver simultáneamente en espacios naturales. Aunque, ha sido muy aplicado en parques nacionales de EEUU, este indicador no ha sido utilizado en espacios naturales confinados como son los cenotes de la península de Yucatán. Esta investigación aplica este indicador generando resultados que pueden utilizarse para una gestión sostenible de estos espacios.
The psychosocial load capacity has proven to be an effective instrument to establish maximum numbers of people that a tourist is willing to see simultaneously in natural spaces. Although, it has been widely applied in national parks in the USA, this indicator has not been used in confined natural spaces such as the cenotes of the Yucatan Peninsula. This research applies this indicator generating results that can be used for sustainable management of these spaces.
El desarrollo turístico en Mazatlán, México: evaluación de la sostenibilidad por medio de indicadores
Authors: Brito Rodríguez Marianne , Cànoves Valiente Gemma 
Published: May 2019

El artículo hace una revisión del desarrollo sostenible como paradigma para guiar la dinámica turística en destinos costeros, planteando la necesidad de hacer evaluaciones locales. Se analiza Mazatlán, México con indicadores para aspectos económico, social, cultural, ambiental y de gobernanza, con el propósito de identificar qué tanto se acerca a un turismo sostenible. Los resultados apuntan a replantearse el modelo turístico que se desarrolla en este y otros destinos mexicanos, considerando que de continuar así los costos sociales y ambientales superarán con creces los beneficios económicos.
The article makes a review of sustainable development as a paradigm to guide the tourist dynamics in coastal destinations, raising the need to make local evaluations. Mazatlan, Mexico is analyzed with indicators for economic, social, cultural, environmental and governance aspects, in order to identify how close a sustainable tourism is. The results point to the rethinking of the tourism model in this and other Mexican destinations, considering that to continue with it, the social and environmental costs will far exceed the economic benefits.
Del turismo inmobiliario al turismo de naturaleza. ¿Cambio de modelo o cambio de discurso? El caso de Noja, un municipio en la costa cantábrica
Authors: Gil de Arriba Carmen 
Published: May 2019

En este artículo se aborda un tipo de relaciones que, a priori, parecen difíciles de conciliar, las que se plantean entre el llamado turismo residencial (denominación bajo la que a menudo se esconden los intereses del sector inmobiliario) y el turismo de naturaleza en espacios litorales. Tras un encuadre de la problemática, hemos optado por un caso de estudio que reúne buena parte de los rasgos que definen este tipo de espacios turísticos: por un lado, fuerte crecimiento inmobiliario, expansión urbana, alto nivel de permisibilidad urbanística y escasa adecuación del modelo a las condiciones ambientales; por otro, entorno de elevado valor ecológico y declaración como espacio natural protegido. Además, este caso de estudio tiene también cualidades específicas o distintivas, entre las que se encuentra su localización en la costa cantábrica, donde estos procesos han sido menos estudiados que en el Mediterráneo, y su proximidad al área metropolitana de Bilbao que ejerce como centro urbano de influencia. A partir del repaso de todas estas características, analizamos si la puesta en valor turístico de un espacio protegido supone un cambio real del modelo residencial e inmobiliario seguido hasta ahora o simplemente la adaptación a unas nuevas condiciones de mercado.
This article studies a relationship, which a priori appears incompatible, between so called residential tourism (a name under which real estate interests lie) and tourism related to nature in coastal areas. After establishing a theoretical and methodological framework, a case study is analysed: the municipality of Noja in the North of Spain. This case combines most of the features that define this area type. On the one hand, strong real estate growth, a high level of urban sprawl and speculation, and limited control and adjustment of the model to environmental conditions. On the other hand, it is an ecologically valuable, protected, natural area. Moreover, this particular case study has specific or distinctive qualities, such as a geographical location on the Cantabrian coast where few studies have been carried out, unlike the Mediterranean coast, and proximity to the influential metropolitan area of Bilbao. Following a review of all of the above characteristics, we analyse whether the implementation of tourist values in a protected space represents a major change in the residential and real estate model pursued to date or whether these changes are just a gradual adjustment to new market conditions.
Especulación urbanística y burbuja inmobiliaria en espacios litorales: factores explicativos del tercer boom turístico de Canarias
Authors: Simancas Cruz Moisés 
Published: May 2019

La dinámica del turismo en las Islas Canarias (España) se ha desarrollado en ciclos económicos. Ello implica la sucesión de momentos de expansión y contracción, que podemos denominar booms turísticos. El tercero (1997-2001) se caracterizó por unas extraordinarias expectativas empresariales, reales y potenciales, de construcción de nuevos alojamientos turísticos. Sin embargo, éstas no respondieron a una demanda real, sino a procesos de especulación urbanística derivadas de los incentivos públicos a la inversión, así como al predominio de los principios de desregulación, privatización y liberalización del mercado. El principal objetivo de este trabajo es analizar los factores urbanísticos-especulativos que explican la génesis y el desarrollo de este tercer boom turístico canario.
The dynamics of tourism in the Canary Islands (Spain) has developed following economic cycles, with the reality succession of times of expansion and contraction, which can be called tourism booms. The third (1997-2001) are characterized by extraordinary business expectations, real and potential, to build new tourist accommodations. However, the processes of urban speculation derived from public incentives for investment and the predominance of the principles of deregulation, privatization and market liberalization. The main objective of this paper is to analyse the urbanistic-speculative factors that explain the genesis and development of the third canarian tourist boom.
Application of the urban exposome framework using drinking water and quality of life indicators: a proof-of-concept study in Limassol, Cyprus
Authors: Andrianou Xanthi D. , van der Lek Chava , Charisiadis Pantelis , Ioannou Solomon , Fotopoulou Kalliopi N. , Papapanagiotou Zoe , Botsaris George , Beumer Carijn , Makris Konstantinos C. 
Published: May 2019

Background
Cities face rapid changes leading to increasing inequalities and emerging public health issues that require cost-effective interventions. The urban exposome concept refers to the continuous monitoring of urban environmental and health indicators using the city and smaller intra-city areas as measurement units in an interdisciplinary approach that combines qualitative and quantitative methods from social sciences, to epidemiology and exposure assessment.

Methods
In this proof of concept study, drinking water and quality of life indicators were described as part of the development of the urban exposome of Limassol (Cyprus) and were combined with agnostic environment-wide association analysis. This study was conducted as a two-part project with a qualitative part assessing the perceptions of city stakeholders, and quantitative part using a cross-sectional study design (an urban population study). We mapped the water quality parameters and participants’ opinions on city life (i.e., neighborhood life, health care, and green space access) using quarters (small administrative areas) as the reference unit of the city. In an exploratory, agnostic, environment-wide association study analysis, we used all variables (questionnaire responses and water quality metrics) to describe correlations between them.

Results
Overall, urban drinking-water quality using conventional indicators of chemical (disinfection byproducts-trihalomethanes (THM)) and microbial (coliforms, E. coli, and Enterococci) quality did not raise particular concerns. The general health and chronic health status of the urban participants were significantly (false discovery rate corrected p-value < 0.1) associated with different health conditions such as hypertension and asthma, as well as having financial issues in access to dental care. Additionally, correlations between THM exposures and participant behavioral characteristics (e.g., household cleaning, drinking water habits) were documented.

Conclusion
This proof-of-concept study showed the potential of using integrative approaches to develop urban exposomic profiles and identifying within-city differences in environmental and health indicators. The characterization of the urban exposome of Limassol will be expanded via the inclusion of biomonitoring tools and untargeted metabolomics.
Plant Products for Health
Authors: Venkataraman Srividhya , Makhzoum Abdullah , Shoaib Erum , Hefferon Kathleen 
Published: May 2019

Abstract

Plants play an essential role in many aspects of human health, including nutrition and medicine. Advancements in biology and engineering have hastened research regarding plant‐based medicines. More specifically, biotechnology has played a significant role in identifying new ways that plants can be utilised. There are three major directions that plants are being developed to improve our health. The first concerns the use of plants as production platforms for modern pharmaceuticals. The second deals with plant biofortification strategies to prevent malnutrition and defeat chronic diseases. The third describes the identification and analysis of bioactive compounds derived from plants in modern medicine. All three sections bring to light mankind's continuous reliance on plants for our current and future health needs.

Key Concepts

Plants play an essential role in many aspects of human health, including nutrition and medicine.

Plants can be used as production platforms for biopharmaceuticals.

Biofortified crops such as Golden Rice and Banana21 can prevent Vitamin A deficiency.

Plant secondary metabolites can be used as a source of bioactive molecules to improve human health.

However, significant opposition to biotechnology has slowed the research and development of plant-based health products.
Engineered Interfusion of Hollow Nitrogen‐Doped Carbon Nanospheres for Improving Electrochemical Behavior and Energy Density of Lithium–Sulfur Batteries
Authors: Li Zhonglin , Xiao Zhubing , Wang Shiqing , Cheng Zhibin , Li Pengyue , Wang Ruihu 
Published: May 2019

AbstractHollow nanostructures are one of promising sulfur host materials for lithium–sulfur (Li–S) batteries, but the ineffective contact among discrete particles usually generates overall poor electrical conductivity and low volumetric energy density. A new interfused hollow nitrogen‐doped carbon (HNPC) material, derived from imidazolium‐based ionic polymer (ImIP)‐encapsulated zeolitic imidazolate framework‐8 (ZIF‐8), is reported. A novel method for ZIF‐8 disassembly induced by the decomposition of the ImIP shell is proposed. The unique structural superiority gives the resultant electrodes remarkable cycling stability, high rate capability, and large volumetric energy density. A stable reversible discharge capacity over 562 mA h g−1 at 2 C is achieved after prolonged cycling for 800 cycles and the average capacity decay per cycle is as low as 0.035%. The electrochemical performance achieved greatly surpasses that of ZIF‐8‐derived carbon matrices and conventional nitrogen‐doped carbon materials. This proposed methodology opens a new avenue for the design of hollow‐structured carbon nanoarchitectures with target functionalities.
Ultra‐Adaptable and Wearable Photonic Skin Based on a Shape‐Memory, Responsive Cellulose Derivative
Authors: Yi Hoon , Lee Sang‐Hyeon , Ko Hyunwook , Lee Dohoon , Bae Won‐Gyu , Kim Tae‐il , Hwang Dong Soo , Jeong Hoon Eui 
Published: May 2019

AbstractPhotonic skins enable a direct and intuitive visualization of various physical and mechanical stimuli with eye‐readable colorations by intimately laminating to target substrates. Their development is still at infancy compared to that of electronic skins. Here, an ultra‐adaptable, large‐area (10 × 10 cm2), multipixel (14 × 14) photonic skin based on a naturally abundant and sustainable biopolymer of a shape‐memory, responsive multiphase cellulose derivative is presented. The wearable, multipixel photonic skin mainly consists of a photonic sensor made of mesophase cholesteric hydroxypropyl cellulose and an ultra‐adaptable adhesive layer made of amorphous hydroxypropyl cellulose. It is demonstrated that with multilayered flexible architectures, the multiphase cellulose derivative–based integrated photonic skin can not only strongly couple to a wide range of biological and engineered surfaces, with a maximum of ≈180 times higher adhesion strengths compared to those of the polydimethylsiloxane adhesive, but also directly convert spatiotemporal stimuli into visible color alterations in the large‐area, multipixel array. These colorations can be simply converted into 3D strain mapping data with digital camera imaging.
Solar‐Driven Rechargeable Lithium–Sulfur Battery
Authors: Chen Peng , Li Guo‐Ran , Li Tian‐Tian , Gao Xue‐Ping 
Published: May 2019

AbstractSolar cells and rechargeable batteries are two key technologies for energy conversion and storage in modern society. Here, an integrated solar‐driven rechargeable lithium–sulfur battery system using a joint carbon electrode in one structure unit is proposed. Specifically, three perovskite solar cells are assembled serially in a single substrate to photocharge a high energy lithium–sulfur (Li–S) battery, accompanied by direct conversion of the solar energy to chemical energy. In the subsequent discharge process, the chemical energy stored in the Li–S battery is further converted to electrical energy. Therefore, the newly designed battery is capable of achieving solar‐to‐chemical energy conversion under solar‐driven conditions, and subsequently delivering electrical energy from the stored chemical energy. With an optimized structure design, a high overall energy conversion efficiency of 5.14% is realized for the integrated battery. Moreover, owing to the self‐adjusting photocharge advantage, the battery system can retain high specific capacity up to 762.4 mAh g−1 under a high photocharge rate within 30 min, showing an effective photocharging feature.
Multiscale analysis of flow patterns in the dense‐phase pneumatic conveying of pulverized coal
Authors: Jin Yong , Lu Haifeng , Guo Xiaolei , Gong Xin 
Published: May 2019

AbstractFour typical flow patterns in the vertical pipe of the dense‐phase pneumatic conveying of pulverized coal were obtained, namely packed bed flow, plug flow, churn flow and less dense phase flow. The electrical capacitance tomography (ECT) was used for space–time multiscale analysis. Firstly, Daubechies second order wavelet transform and rescaled range analysis(R/S) were applied for the scientific multiscale decompositions. The multiscale frequency range is that the microscale signal is d1–d5 (2.1875, 70.0000) Hz, the mesoscale signal is d6 and d7 (0.5469, 2.1875) Hz and the macroscale signal is d8–d11 (0.0342, 0.5469) Hz. The multiscale ECT signal characteristics of pure gas flow, particle–wall friction, and particle–particle collision were determined by experiments. The multiscale ECT signal energy matrix is proposed, based on the multiscale energy structure characteristics. Control mechanisms and multiscale statistical rules of four typical flow patterns are obtained. This study provides theoretical support for the study of flow pattern transformation of dense‐phase pneumatic conveying.
Genetic variants in the KDM6B gene are associated with neurodevelopmental delays and dysmorphic features
Authors: Stolerman Elliot S. , Francisco Elizabeth , Stallworth Jennifer L. , Jones Julie R. , Monaghan Kristin G. , Keller‐Ramey Jennifer , Person Richard , Wentzensen Ingrid M. , McWalter Kirsty , Keren Boris , Heron Benedicte , Nava Caroline , Heron Delphine , Kim Katherine , Burton Barbara , Al‐Musafri Fatima , O'Grady Lauren , Sahai Inderneel , Escobar Luis F. , Meuwissen Marije , Reyniers Edwin , Kooy Frank , Lacassie Yves , Gunay‐Aygun Meral , Schatz Krista Sondergaard , Hochstenbach Ron , Zwijnenburg Petra J.G. , Waisfisz Quinten , van Slegtenhorst Marjon , Mancini Grazia M.S. , Louie Raymond J. 
Published: May 2019

AbstractLysine‐specific demethylase 6B (KDM6B) demethylates trimethylated lysine‐27 on histone H3. The methylation and demethylation of histone proteins affects gene expression during development. Pathogenic alterations in histone lysine methylation and demethylation genes have been associated with multiple neurodevelopmental disorders. We have identified a number of de novo alterations in the KDM6B gene via whole exome sequencing (WES) in a cohort of 12 unrelated patients with developmental delay, intellectual disability, dysmorphic facial features, and other clinical findings. Our findings will allow for further investigation in to the role of the KDM6B gene in human neurodevelopmental disorders.
International Society of Psychiatric Genetics Ethics Committee: Issues facing us
Authors: Lázaro‐Muñoz Gabriel , Sabatello Maya , Huckins Laura , Peay Holly , Degenhardt Franziska , Meiser Bettina , Lencz Todd , Soda Takahiro , Docherty Anna , Crepaz‐Keay David , Austin Jehannine , Peterson Roseann E. , Davis Lea K. ,   on behalf of the ISPG Ethics Committee
Published: May 2019

AbstractPsychiatric genetics research is improving our understanding of the biological underpinnings of neurodiversity and mental illness. Using psychiatric genetics in ways that maximize benefits and minimize harms to individuals and society depends largely on how the ethical, legal, and social implications (ELSI) of psychiatric genetics are managed. The International Society of Psychiatric Genetics (ISPG) is the largest international organization dedicated to psychiatric genetics. Given its history, membership, and international reach, we believe the ISPG is well‐equipped to contribute to the resolution of these ELSI challenges. As such, we recently created the ISPG Ethics Committee, an interdisciplinary group comprised of psychiatric genetics researchers, clinical geneticists, genetic counselors, mental health professionals, patients, patient advocates, bioethicists, and lawyers. This article highlights key ELSI challenges identified by the ISPG Ethics Committee to be of paramount importance for the ethical translation of psychiatric research into society in three contexts: research settings, clinical settings, and legal proceedings. For each of these arenas, we identify and discuss pressing psychiatric genetics ELSI dilemmas that merit attention and require action. The goal is to increase awareness about psychiatric genetics ELSI issues and encourage dialogue and action among stakeholders.
Deoxynucleoside Therapy for Thymidine Kinase 2–Deficient Myopathy
Authors: Domínguez‐González Cristina , Madruga‐Garrido Marcos , Mavillard Fabiola , Garone Caterina , Aguirre‐Rodríguez Francisco Javier , Donati M. Alice , Kleinsteuber Karin , Martí Itxaso , Martín‐Hernández Elena , Morealejo‐Aycinena Juan P. , Munell Francina , Nascimento Andrés , Kalko Susana G. , Sardina M. Dolores , Álvarez del Vayo Concepcion , Serrano Olga , Long Yuelin , Tu Yuqi , Levin Bruce , Thompson John L. P. , Engelstad Kristen , Uddin Jasim , Torres‐Torronteras Javier , Jimenez‐Mallebrera Cecilia , Martí Ramon , Paradas Carmen , Hirano Michio 
Published: May 2019

ObjectiveThymidine kinase 2, encoded by the nuclear gene TK2, is required for mitochondrial DNA maintenance. Autosomal recessive TK2 mutations cause depletion and multiple deletions of mtDNA that manifest predominantly as a myopathy usually beginning in childhood and progressing relentlessly. We investigated the safety and efficacy of deoxynucleoside monophosphate and deoxynucleoside therapies.MethodsWe administered deoxynucleoside monophosphates and deoxynucleoside to 16 TK2‐deficient patients under a compassionate use program.ResultsIn 5 patients with early onset and severe disease, survival and motor functions were better than historically untreated patients. In 11 childhood and adult onset patients, clinical measures stabilized or improved. Three of 8 patients who were nonambulatory at baseline gained the ability to walk on therapy; 4 of 5 patients who required enteric nutrition were able to discontinue feeding tube use; and 1 of 9 patients who required mechanical ventilation became able to breathe independently. In motor functional scales, improvements were observed in the 6‐minute walk test performance in 7 of 8 subjects, Egen Klassifikation in 2 of 3, and North Star Ambulatory Assessment in all 5 tested. Baseline elevated serum growth differentiation factor 15 levels decreased with treatment in all 7 patients tested. A side effect observed in 8 of the 16 patients was dose‐dependent diarrhea, which did not require withdrawal of treatment. Among 12 other TK2 patients treated with deoxynucleoside, 2 adults developed elevated liver enzymes that normalized following discontinuation of therapy.InterpretationThis open‐label study indicates favorable side effect profiles and clinical efficacy of deoxynucleoside monophosphate and deoxynucleoside therapies for TK2 deficiency. ANN NEUROL 2019;86:293–303