bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning of the Electro-Optical Properties of Tetraphenylcyclopentadienone via Substitution of Oxygen with Sterically-Hindered Electron Withdrawing Groups
Authors: Coluccini Carmine , Anusha Puliparambil Thilakan , Chen Hsin-Yi Tiffany , Liao Sheng-Lun , Ko Ying Kuan , Yabushita Atsushi , Luo Chih Wei , Ng Yoke Mooi , Khung Yit Lung 
Published: September 2019

AbstractIn this report, the substitution of the oxygen group (=O) of Tetraphenylcyclopentadienone with =CR2 group (R = methyl ester or nitrile) was found to have tuned the electro-optical properties of the molecule. Although both groups are electrons withdrawing in nature, their absorption from UV-vis spectra analysis was observed to have been blue-shifted by methyl ester substitution and red-shifted by nitrile substitution. Interestingly, these substitutions helped to enhance the overall intensity of emission, especially in the context of methyl ester substitution whereby the emission was significantly boosted at higher concentrations due to hypothesized restrictions of intramolecular motions. These observations were explained through detailed descriptions of the electron withdrawing capability and steric properties of the substituents on the basis of density functional theory calculations.
Aerosol-induced modification of organised convection and top-of-atmosphere radiation
Authors: Nishant Nidhi , Sherwood Steven C. , Geoffroy Olivier 
Published: September 2019

AbstractAerosol effects on cloud cover and precipitation could affect the global climate but have proven difficult to verify, because cloud and rain amounts are so strongly influenced by local meteorological conditions. Here model and observational evidence is presented that an increase in CCN concentration slightly invigorates mixed-phase convective clouds and narrows tropical convergence and rain bands, while expanding associated cloud cover particularly at mid-levels. A suite of model simulations with various approaches indicates a 4 ± 3.8% decrease in the rain-to-cloud area ratio per doubling of the CCN concentration, an effect also detected in satellite observations. Idealised numerical experiments suggest the area ratio change is due to the invigoration-induced static stability increase. Although the invigoration and cloud amount changes are much smaller than suggested in some studies, in simulations the latter cool the planet by 0.71 ± 0.25 W/m2 in deep convective regions, suggesting a global effect of order 0.2–0.5 W/m2, per aerosol doubling. The contribution to present-day anthropogenic forcing is even harder to quantify but could compare to that of the direct aerosol radiative forcing. These results indicate a previously unrecognised pathway for aerosols to indirectly cool the climate by altering convective clouds dynamically.
Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer
Authors: Ziliotto Silvia , Gee Julia M W , Ellis Ian O , Green Andrew R , Finlay Pauline , Gobbato Anna , Taylor Kathryn M 
Published: September 2019

AbstractZIP7, a member of the ZIP family of zinc importers, resides on the endoplasmic reticulum membrane and transports zinc from intracellular stores to the cytoplasm after activation by CK2 phosphorylation on two serine residues (S275 and S276). ZIP7 is known to be required for the growth of anti-hormone resistant breast cancer models, especially those with acquired tamoxifen resistance developed from MCF-7. Using our new pS275S276ZIP7 antibody which only recognises activated ZIP7 (pZIP7), we have demonstrated that the hyperactivation of ZIP7 is prevalent in tamoxifen-resistant breast cancer cells. This evidence suggests that pZIP7 might have potential as a biomarker of acquired resistance to such anti-hormones in breast cancer, a current unmet clinical need. In this regard, we have also developed a new immunohistochemical assay for pZIP7 which allowed pZIP7 to be tested on a small clinical series of breast cancer tissues confirming its prevalence in such tumours and relationship to a variety of clinicopathological parameters and biomarkers previously associated with endocrine resistant phenotypes, notably increased activated MAPK signalling, expression of ErbB2, CD71 and the proto-oncogene c-Fos, as well as with increased tumour grade.
miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway
Authors: Chen Xuan-Ying , Huang Wei-Lin , Peng Xiao-Ping , Lv Yan-Ni , Li Jun-He , Xiong Jian-Ping 
Published: September 2019

Abstract
Bevacizumab (BVZ) is the first recombinant humanized monoclonal antibody against vascular endothelial growth factor (VEGFA) approved by the FDA for the treatment of different kinds of cancers, especially colorectal cancer. Although the anti-tumor effects have been verified, the side effects of BVZ are also noteworthy, among which, cardiotoxicity may be the most serious side effect of BVZ. However, the exact mechanisms of cardiotoxicity induced by BVZ have been little explored. This study was conducted in vitro in a human cardiac myocyte (HCM) model. MTT assay was conducted to determine BVZ-stimulated cell viability. For testing the function and mechanism, the cells were transfected with miR-140-5p mimics, miR-140-5p inhibitor and/or VEGFA small interfering RNA (si-VEGFA). Then, apoptosis of the cells was detected via annexin V/propidium iodide (AV-PI) staining followed by flow cytometry. qRT-PCR and western blot assays were applied to measure gene expression (i.e. mRNA) and protein levels, respectively. The CK, LDH, SOD, CAT and GSH-Px activities and MDA level were determined using commercial kits. ROS levels were determined by DCFH-DA assay. Mitochondrial membrane potential was measured by JC-1 assay. Dual-luciferase reporter assay was used to detect the interaction between miR-140-5p and VEGFA. BVZ could inhibit HCM proliferation and induce apoptosis. miR-140-5p was upregulated in response to BVZ treatment and miR-140-5p restraint could alleviate HCM damage caused by BVZ treatment. In contrast, VEGFA and 14-3-3γ expressions were down-regulated by BVZ, and miR-140-5p could inhibit the expression of 14-3-3γ by directly targeting VEGFA. Moreover, VEGFA suppression enhanced HCM injury stimulated by BVZ and partially reversed the functional role of the miR-140-5p inhibitor in BVZ-treated cells. Taken together, miR-140-5p promoted BVZ-treated cardiomyocyte toxicity by targeting the VEGFA/14-3-3γ signal pathway. Collectively, miR-140-5p mediated the BVZ-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway, indicating that miR-140-5p may be a novel target for treating BVZ-induced cardiotoxicity.
Conserved bases for the initial cyclase in gibberellin biosynthesis: from bacteria to plants
Authors: Lemke Cody , Potter Kevin C. , Schulte Samuel , Peters Reuben J. 
Published: September 2019

Abstract
All land plants contain at least one class II diterpene cyclase (DTC), which utilize an acid-base catalytic mechanism, for the requisite production of ent-copalyl diphosphate (ent-CPP) in gibberellin A (GA) phytohormone biosynthesis. These ent-CPP synthases (CPSs) are hypothesized to be derived from ancient bacterial origins and, in turn, to have given rise to the frequently observed additional DTCs utilized in more specialized plant metabolism. However, such gene duplication and neo-functionalization has occurred repeatedly, reducing the utility of phylogenetic analyses. Support for evolutionary scenarios can be found in more specific conservation of key enzymatic features. While DTCs generally utilize a DxDD motif as the catalytic acid, the identity of the catalytic base seems to vary depending, at least in part, on product outcome. The CPS from Arabidopsis thaliana has been found to utilize a histidine-asparagine dyad to ligate a water molecule that serves as the catalytic base, with alanine substitution leading to the production of 8β-hydroxy-ent-CPP. Here this dyad and effect of Ala substitution is shown to be specifically conserved in plant CPSs involved in GA biosynthesis, providing insight into plant DTC evolution and assisting functional assignment. Even more strikingly, while GA biosynthesis arose independently in plant-associated bacteria and fungi, the catalytic base dyad also is specifically found in the relevant bacterial, but not fungal, CPSs. This suggests functional conservation of CPSs from bacteria to plants, presumably reflecting an early role for derived diterpenoids in both plant development and plant–microbe interactions, eventually leading to GA, and a speculative evolutionary scenario is presented.
Clinical value of a plasma Epstein–Barr virus DNA assay in the diagnosis of recurrent or metastatic nasopharyngeal carcinoma: a meta-analysis
Authors: Peng Haiqin , Li Zhanzhan , Long Yujiao , Li Jiahui , Liu Zhiyuan , Zhou Rongrong 
Published: September 2019

Abstract
Background: To evaluate the diagnostic value of Epstein–Barr virus (EBV) DNA in nasopharyngeal carcinoma (NPC) patients with locoregional or distant recurrence.
Methods: Articles related to the diagnosis of recurrent or metastatic NPC by the detection of EBV DNA in plasma or serum were retrieved from different databases. Sensitivity, specificity, summary receiver operating characteristic (SROC) curves, and likelihood ratios were pooled to assess the diagnostic value of individual diagnostic tests.
Results: This meta-analysis pooled 25 eligible studies including 2496 patients with NPC. The sensitivity, specificity, positive likelihood ratio (+LR), and negative likelihood ratio (−LR) of EBV DNA in the diagnosis of NPC were 0.858 (95% confidence interval (CI): 0.801–0.901), 0.890 (95% CI: 0.866–0.909), 7.782 (95% CI: 6.423–9.429) and 0.159 (95% CI: 0.112–0.226), respectively. The diagnostic odds ratio (DOR) was 48.865 (95% CI: 31.903–74.845). The SROC for EBV DNA detection was 0.93 (95% CI: 0.90–0.95).
Conclusion: The detection of EBV DNA for the diagnosis of recurrent or metastatic NPC has good sensitivity and specificity and might be helpful in monitoring recurrent or metastatic NPC.
Gewichtsstabilisierung nach
Gewichtsreduktion
Authors: de Zwaan Martina 
Published: September 2019

ZusammenfassungDie Adipositas wird als chronische Erkrankung mit hoher Rezidivneigung gesehen.
Daher müssen über die Phase der Gewichtsabnahme hinaus langfristige Maßnahmen
zur Gewichtsstabilisierung angeboten werden. Einen erfolgreichen Gewichtsverlust
zu halten wird durch unsere adipogene Umwelt, physiologische Veränderungen nach
Gewichtsabnahme und psychologische Faktoren erschwert. Um Verhaltensänderungen,
die eine Gewichtsstabilisierung unterstützen, zu erreichen, werden eine
Anpassung der therapeutischen Haltung sowie spezifische therapeutische Ansätze
empfohlen.
Photosystem II oxygen-evolving complex photoassembly displays an inverse H/D solvent isotope effect under chloride-limiting conditions
Authors: Vinyard David J. , Badshah Syed Lal , Riggio M. Rita , Kaur Divya , Fanguy Annaliesa R. , Gunner M. R. 
Published: September 2019

SignificanceMetal clusters play important roles in a wide variety of proteins. In cyanobacteria, algae, and plants, photosystem II uses light energy to oxidize water and release O2at an active site that contains 1 calcium and 4 manganese atoms. This cluster must be built within the protein environment through a process known as photoassembly. Through experiments and simulations, we found that the efficiency of photoassembly was highly dependent on protons and chloride. Surprisingly, when the solvent was switched from H2O to deuterated water, D2O, the yield of photoassembly was higher. These results provide insights into the stepwise mechanism of photoassembly that can inform synthesis and repair strategies being developed for artificial photosynthesis technologies.
The interaction between inhibitory control and corrective feedback timing
Authors: Yilmaz Yucel , Sağdıç Ayşenur 
Published: September 2019

Abstract
This article reports a study investigating the role of inhibitory control in the acquisition of Spanish noun-adjective gender agreement under different feedback timing conditions. Forty-three Spanish learners completed a communicative task through synchronous computer-mediated communication. The immediate group received reformulations immediately after their errors, whereas the delayed group received reformulations at the end of the task. The control group did not receive any feedback. Learners’ knowledge of the target form was assessed using oral production and grammaticality judgment tests at three different times: once before the treatment, once immediately after the treatment, and once ten days after the treatment. Inhibitory control was measured with the Flanker test. Results did not show a statistically significant interaction between inhibitory control and feedback timing group on either outcome measure even though the correlations between learners’ gains and inhibitory control were different across groups.
Daily administration of Sake Lees (Sake Kasu) reduced psychophysical stress-induced hyperalgesia and Fos responses in the lumbar spinal dorsal horn evoked by noxious stimulation to the hindpaw in the rats
Authors: Shimizu Shiho , Nakatani Yosuke , Kakihara Yoshito , Taiyoji Mayumi , Saeki Makio , Takagi Ritsuo , Yamamura Kensuke , Okamoto Keiichiro 
Published: September 2019

ABSTRACT
We tested whether Sake Lees (SL) had inhibitory effects on hyperalgesia in the hindpaw under psychophysical stress conditions. Male rats were subjected to repeated forced swim stress treatments (FST) from Day −3 to Day −1. Intraperiotoneal administration of SL which contained low concentration of ethanol (SLX) was conducted after each FST. On Day 0, formalin-evoked licking behaviors and Fos responses in the lumbar spinal cord (DH) and several areas within the rostral ventromedial medulla (RVM) were quantified as nociceptive responses. FST-induced hyperalgesia in the hindpaw was prevented by repeated SL and SLX treatments. Fos expression was significantly increased in DH and some areas within the RVM under FST, which was prevented by repeated SL or SLX. These findings indicated that daily administration of SL had the potential to alleviate stress-induced hyperalgesia.
The potential and challenges of time-resolved single-photon detection based on current-carrying superconducting nanowires
Authors: Zhang Hengbin , Xiao Lin , Luo Bingcheng , Guo Jianghua , Zhang Labao , Xie Jun 
Published: September 2019

Abstract
Superconducting nanowire-based devices are being hailed as promising single-photon detectors that exhibit excellent combined properties. In particular, their unrivalled time-resolution ability has made these devices potentially revolutionary for the commercial ultrafast single-photon measurement and analysis fields. In this review, we present a detailed summary of the influencing factors and the intrinsic physical mechanism of the temporal resolution in superconducting nanowire single-photon detectors (SNSPDs). We elaborate on the two internal components of temporal resolution, the time response and time jitter, as well as on many measurement methods and device structure modifications attempted to exclude external interference, thus approaching the ultimate limits of time-resolved single photon detection. The investigation of the temporal resolution of SNSPDs not only sheds light on the intrinsic physical mechanism but also contributes to time-related practical engineering applications.
State independent contextuality advances one-way communication
Authors: Saha Debashis , Horodecki Paweł , Pawłowski Marcin 
Published: September 2019

Abstract
Although ‘quantum contextuality’ is one of the most fundamental non-classical feature, its generic role in information processing and computation is an open quest. In this article, we present a family of distributed computing tasks pertaining to every logical proof of Kochen–Specker (KS) contextuality in two different one-way communication scenarios: (I) communication of bounded dimensional system, (II) communication of unbounded dimensional system while keeping certain information oblivious, namely, oblivious communication (OC). As the later remains largely unexplored, we introduce a general framework for OC tasks and provide a methodology for obtaining an upper bound on the success of OC tasks in classical communication. We show that quantum communication comprised of every KS set of vectors outperforms classical communication and perfectly accomplish the task in both the aforementioned scenarios. We explicitly discuss the communication tasks pertaining to the simplest state independent contextuality sets of dimension three and four. Our results establish an operational significance to single system contextuality and open up the possibility of semi-device independent quantum information processing based on that. Alongside, we identify any advantage in OC tasks as a witness of preparation contextuality.
On quantumness in multi-parameter quantum estimation
Authors: Carollo Angelo , Spagnolo Bernardo , Dubkov Alexander A , Valenti Davide 
Published: September 2019

Abstract
In this article we derive a measure of quantumness in quantum multi-parameter estimation problems. We can show that the ratio between the mean Uhlmann curvature and the Fisher information provides a figure of merit which estimates the amount of incompatibility arising from the quantum nature of the underlying physical system. This ratio accounts for the discrepancy between the attainable precision in the simultaneous estimation of multiple parameters and the precision predicted by the Cramér–Rao bound. As a testbed for this concept, we consider a quantum many-body system in thermal equilibrium, and explore the quantum compatibility of the model across its phase diagram.
Dynamical forming and applications of nanocomposites from organic and inorganic components for new trends in material research and technologies
Authors: Cebruk I S , Pokidov A P , Kedrov V V , Klassen N V 
Published: September 2019

Abstract
The composite scintillators from inorganic scintillators and organic phosphors provide unique combination of high light yield and nanosecond temporal resolution. Preparation of microfibers of these composites by means of centrifugation resulted in forming of axial nanosplitting and transverse micromodulation of their structure and optical properties, These modulations result in essential improvement of scintillation parameters of the composite providing the development of relatively simple and cheap X-Ray microscope. Ball rolling of inorganic solids provides superfast introduction of organic and inorganic components into subsurface layers for the special modifications of their properties. The superfast introduction is explained by propagation of nanocracks involving necessary dopants into the solid.
Eddy currents in fine polycrystalline metal particle
Authors: Bassel M , Yushkanov A A 
Published: September 2019

Abstract
The magnetic dipole absorption in fine metal polycrystalline particle is considered. The kinetic equation with a collision integral that takes into account the influence of electron scattering at the grain boundaries on the properties of the metal has been solved. We consider the case of diffuse reflection of electrons from the sample surface Analysis of the dependence of the absorption cross section of particles from the parameter describing the degree of influence of the scattering on the grain boundaries of polycrystalline particles on the kinetic processes has been considered.
Heat transfer in the boundary layer in an incompressible fluid in terms of waveguide turbulence model
Authors: Zharov V A , Selim R S 
Published: September 2019

Abstract
The possibility of the description of the heat transfer processes in the developed turbulent boundary layer on the flat plate at zero angle attack with zero longitudinal pressure gradient in incompressible fluid is considered as a consequence of the waveguide theory of turbulent boundary layer. It is shown that the logarithmic distribution of temperature along normal coordinates arises in a natural way. It is pointed out the possibility of the intensification of the heat transfer due to generation of own modes of the temperature pulsations. The problem of heat transfer in a boundary layer on a plate flow round an incompressible fluid using the collocation method with Chebyshev polynomial is considered. The dependence of the eigen frequency of the least damped mode on the wave number is obtained. The amplitude of the exicted mode obeys the direct resonance equation if external excitation is applied to the system.
Kinetics of large scale vertical flow generation by weakly noncollinear nonlinear gravitational waves
Authors: Poplevin A V , Filatov S V , Brazhnikov M Yh , Likhter A M 
Published: September 2019

Abstract
The generation of a large-scale vortex flow by gravity waves on the water surface has been experimentally studied. It is shown that large-scale flows are formed as a result of the interaction between nonlinear low-frequency modes which intersect at small angles. The amplitude of vorticity at large scales increases with increasing angle between pump waves. The experimental data agree well with the developed theoretical model.
Features of nonlinear optical properties of thin-film phthalocyanine coatings obtained by femtosecond hardware-software Z-scan measurement complex
Authors: Khorkov K S , Chkalov R V , Kochuev D A , Kazak A V , Pushkarev V E , Tolbin A Yu 
Published: September 2019

Abstract
In this paper, we study the nonlinear optical properties of thin-film phthalocyanine coatings based on the developed femtosecond hardware-software complex Z-scan. As a control of the complex, a combined system is used to ensure the synchronization of all components of the installation, as well as to automate the process of data collection and processing, which greatly simplifies the process of conducting the Z-scanning experiment. The results of measurement of nonlinear optical properties of the phthalocyanine thin films using femtosecond laser radiation are presented.
BAM and GID structural investigation of 1,4,8,11,15,18-hexahexyloxy-22,23,24,25-tetrachlorophthalocyanine floating layers
Authors: Smirnova A , Kazak A , Kovaleva M , Marchenkova M , Rogachev A , Chausov D N , Glukhovskoy E , Usol’tseva N 
Published: September 2019

Abstract
The article presents a comprehensive study of the supramolecular organization of floating layers of the mix-substituted phthalocyanine of A3B-type (1,4,8,11,15,18-hexahexyloxy-22,23,24,25-tetrachlorophthalocyanine). Molecular packing modeling of the studied compound in monolayer structures on the water surface was simulated, and the parameters of the unit cell of the monolayer were calculated. On the base of these data, the supramolecular organization of the floating layers was proposed. Using Brewster microscopy (BAM) and grazing incidence X-ray diffraction (GID), it was shown that at the water/air interface the studied phthalocyanine forms a stable bilayer crystalline structure with an imperceptible number of 3D-aggregates. Interplanar spacing of the crystalline bilayer is 1.93 nm.
Sensitization of photoconductive soluble polyimides by dyes of rylene series with synergetic interaction between them
Authors: Rumyantsev B M , Berendyaev V I , Bibikov S B , Kuznetsov A A , Tsegelskaya A Ju 
Published: September 2019

Abstract
Using a mixture of two rylene dyes (D1 (400-620 nm and D2 (620-720 nm)) for obtaining polyimide composites with panchromatic photoelectrical sensitivity (PES) (400-720 nm) the considerable increase of both PES value and photogeneration charge carrier quantum yield in D2 absorption band is revealed caused by the presence of D1 dye (Synergetic Effect (SE)). The conditions of SE appearance and its mechanism are investigated.