bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reynoutria Japonica from Traditional Chinese Medicine: A Source of Competitive Adenosine Deaminase Inhibitors for Anticancer
Authors: Zhang Xin-guo , Ma Guo-Yan , Kou Fei , Liu Wen-Jie , Sun Qiao-Yun , Guo Guang-Jun , Ma Xiao-Di , Guo Si-Jia , Jian-Ning Zhu 
Published: April 2019

Background:Adenosine deaminase (ADA) is an important enzyme in purine metabolism and is known as a potential therapeutic target for the treatment of lymphoproliferative disorders and cancer. Traditional Chinese Herbal Medicine (TCHM) is widely used alone or in combination with chemotherapy to treat cancer, due to its ability to deliver a broad variety of bioactive secondary metabolites as promising sources of novel organic natural agents.Objective:In the present study, 29 varieties of medicinal plants were screened for the presence of ADA inhibitors.Result:Extracts from Reynoutria japonica, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Magnolia officinalis, Gardenia jasminoides, Stephania tetrandra, Commiphora myrrha, Raphanus sativus and Corydalis yanhusuo demonstrated strong ADA inhibition with rates greater than 50%. However, Reynoutria japonica possessed the highest ADA inhibitory activity at 95.26% and so was used in our study for isolating the ADA inhibitor to be further studied. Eight compounds were obtained and their structures were identified. The compound H1 had strong ADA inhibitory activity and was deduced to be emodin by 1H and 13C-NMR spectroscopic analysis with an IC50 of 0.629 mM. The molecular docking data showed that emodin could bind tightly to the active site of ADA. Our results demonstrated that emodin displayed a new biological activity which is ADA inhibitory activity with high cytotoxic activity against K562 leukemia cells. The bioactivity of cordycepin was significantly increased when used in combination with emodin.Conclusion:Emodin may represent a good candidate anti-cancer therapy and adenosine protective agent.
Video-assisted Thoracoscopic Surgery versus Thoracotomy for Non-Small Cell Lung Cancer: A Meta-Analysis
Authors: Ye Bo , Wang Ming 
Published: April 2019

Background:Patients undergoing surgery for non-small cell lung cancer (NSCLC) are often elderly and have co-morbidity conditions and decreased performance status. Compared with open thoracotomy, video-assisted thoracoscopic lobectomy is associated with fewer postoperative complications. Despite encouraging results for patients with NSCLC who underwent VATS, the procedure is still not widely accepted, and large retrospective studies have yielded conflicting results.Objectives:In video-assisted lobectomy for NSCLC, it has remained controversial whether mediastinal lymphadenectomy can be performed as effectively as an open procedure via thoracotomy. To deal with inherent biases in any non-randomized comparison, we analyzed propensity-matched studies and randomized controlled trials. The aim of this study was to evaluate the treatment outcomes of VATS and open thoracotomy for NSCLC patients.Methods:We collected publications on comparison of VATS versus open thoracotomy for NSCLC patients from 2007 to 2017. All trials analyzed the summary Hazard Ratios (HRs) of the endpoints of interest, including perioperative mortality and morbidity, and individual postoperative complications. Revman 5.3 software was used to analyze the combined pooled HRs using fixed- or random-effects models according to heterogeneity.Results:A systematic literature search was conducted including 15 studies. The results indicated that VATS was associated with lower postoperative morbidity and mortality, and significantly lower rates of prolonged pneumonia, atrial arrhythmias and renal failure.Conclusions:Compared with lobectomy by thoracotomy, thoracoscopic lobectomy is associated with a lower incidence of major complications, including lower rates of prolonged pneumonia, atrial arrhythmias and renal failure. Lobectomy via VATs may be the preferred strategy for appropriately selected NSCLC patients. The determinants of this advantage should be analyzed to improve the safety and outcomes of other thoracic procedures.
Downregulation of TdT Expression through Splicing Modulation by Antisense Peptide Nucleic Acid (PNA)
Authors: Montazersaheb Soheila , Kazemi Masoumeh , Nabat Elahe , Nielsen Peter E. , Hejazi Mohammad S. 
Published: April 2019

Background and Objective:Antisense oligonucleotides are able to modulate splicing patterns and offer therapeutic intervention for cancer and other diseases. Considering TdT potential as a target in cancer therapy, the present study aimed to investigate splicing alteration of TdT pre-mRNA in Molt-4 cells using peptide nucleic acid (PNA) octaarginine and cholic acid conjugates.Method:We examined 16 mer PNAs targeting 5' and 3' junctions of intron 7 and addressed their mRNA splicing modulation effects using RT-PCR analysis. We also tested corresponding 2-base mismatch PNAs to confirm the sequence specificity. In addition, protien level of TdT, apoptosis induction and cell viability rate were analysed.Results:PCR analysis showed that full match PNAs could modulate the splicing process, thereby producing a longer mRNA still including intron 7. PCR results also implied exon 7 skipping. In addition, reduced level of TdT protein in Molt-4 cells was observed. Downregulation of TdT level in PNA treated cells was accompanied by an increased rate of apoptosis and decreased the level of cell survival.Conclusion:PNA-mediated splicing modulation can specifically downregulate TdT expression. TdT dowregulation results in apoptosis induction and reduced cell survival in Molt-4 cells. These observations could draw more attentions to develop PNA based strategies for TdT suppression and consequent apoptosis induction in acute lymphoblastic leukemia.
Hypertension in Metabolic Syndrome: Novel Insights
Authors: Katsimardou Alexandra , Imprialos Konstantinos , Stavropoulos Konstantinos , Sachinidis Alexandros , Doumas Michalis , Athyros Vasilios 
Published: April 2019

Background:
Metabolic syndrome (MetS) is characterized by the simultaneous presence
of obesity, hypertension, dyslipidemia and hyperglycemia in an individual, leading to increased
cardiovascular disease (CVD) risk. It affects almost 35% of the US adult population, while its
prevalence increases with age. Elevated blood pressure is the most frequent component of the syndrome;
however, until now, the optimal antihypertensive regiment has not been defined.

Objective:
The purpose of this review is to present the proposed definitions for the metabolic syndrome,
as well as the prevalence of hypertension in this condition. Moreover, evidence regarding
the metabolic properties of the different antihypertensive drug classes and their effect on MetS will
be displayed.

Method:
A comprehensive review of the literature was performed to identify data from clinical
studies for the prevalence, pathophysiology and treatment of hypertension in the metabolic syndrome.

Results:
Hypertension is present in almost 80% of patients with metabolic syndrome. The use of
thiazide diuretics and b-blockers has been discouraged in this population; however, new evidence
suggests their use under specific conditions. Calcium channel blockers seem to exert a neutral effect
on MetS, while renin-angiotensin system inhibitors are believed to be of the most benefit, although
differences exist between the different agents of this category.

Conclusion:
Controversy still exists regarding the optimal antihypertensive treatment for hypertension
in MetS. Due to the high prevalence of hypertension in this population, more data from clinical
trials are needed in the future.
Synthesis ofβ-Ketosulfone Derivatives As New Non-Cytotoxic Urease InhibitorsIn Vitro
Authors: Iqbal Sarosh , Khan Ajmal , Nazir Rashid , Kiran Shumaila , Perveen Shahnaz , Khan Khalid M. , Choudhary Muhammad I. 
Published: April 2019

Background:Peptic ulcer and urolithiasis are largely due to infection caused by ureaseproducing bacteria. Therefore, the discovery of urease inhibitors is an important area of medicinal chemistry research.Objective:The main aim of the work was to identify novel urease inhibitors with no cytotoxicity.Method:During the current study, a series of β-ketosulfones 1-26 was synthesized in two steps and evaluated for their in vitro urease inhibition potential.Results:Out of twenty-six compounds, seventeen have shown good to significant urease inhibitory activity with IC50 values ranging between 49.93-351.46 µM, in comparison to standard thiourea (IC50 = 21 ± 0.11 µM). Moreover, all compounds found to be non-cytotoxic against normal 3T3 cell line.Conclusion:This study has identified β-ketosulfones as novel and non-cytotoxic urease inhibitors.
Manajemen layanan perpustakaan universitas pascaunifikasi perguruan tinggi di perpustakaan Universitas Nurul Jadid Paiton Probolinggo
Authors: Rifa'i Moh , Amin Muhammad Fahrizal 
Published: April 2019

Penelitian ini bertujuan untuk mendeskripsikan manajemen layanan perpustakaan universitas di perpustakaan Universitas Nurul Jadid Paiton Probolinggo meliputi perencanaan, pengorganisasian, pelaksanaan dan pengawasan. Jenis Penelitian ini menggunakan penelitian deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data dilakukan dengan cara wawancara mendalam, observasi lapangan, dan dokumentasi. Sedangkan teknik analisis data yang diterapkan adalah model Miles dan Huberman dengan menggunakan reduksi data, penyajian data, penarikan kesimpulan dan verifikasi data. Dengan uji keabsahan data melalui kredibilitas dengan teknik triangulasi sumber. Penelitian ini berfokus pada keadaan sebenarnya yang terjadi di perpustakaan Universitas Nurul Jadid setelah unifikasi. Hasil penelitian menunjukan bahwa perpustakaan Universitas Nurul Jadid masih pada taraf perpustakaan berkembang diukur berdasarkan visi dan misinya. Perencanaan perpustakaan Universitas Nurul Jadid sudah memadai secara prosedur dan syarat pembuatan visi dan misi. Pengorganisasian masih belum berstandar perpustakaan universitas karena SDM tidak lulusan linear dan belum tersertifikasi. Pelaksanaan masih ditemukan kendala sarana prasarana. Sedangkan pengawasan belum maksimal karena tidak dilakukan sesuai prosedur yang telah ditetapkan. Post unification university library services management in the library of Universitas Nurul Jadid Paiton Probolinggo AbstractThis research is aimed to describe university library service management in the library of Nurul Jadid University Paiton Probolinggo included planning, organizing, actuating and controlling. This study using descriptive qualitative method. Data collection technique is using depth interview, range observatory, and documentations. Technic of data analysis is using Miles and Huberman models; data reduction, data presentation, data conclusion, and verification. From data credibility taken from triangulation data source. This study focuses on the natural setting in the library at Nurul Jadid University after unification. The result of this study indicates that library Nurul Jadid University is still in developing library level based on its vision and mission. The planning of library Nurul Jadid University is already adequate in procedural and requisite. The organization is still not standardization university library because human resources of its library are not from the linear subject and still not certification. The actuating found constraints on facilities and infrastructures. While supervision is not maximal because it is not carried out according to the prescribed procedures.
Peningkatan Kesadaran terhadap Cagar Budaya di Kotabaru Melalui Kegiatan Jelajah Wisata Heritage bagi Generasi Muda di Kota Yogyakarta
Authors: Prihantoro Fahmi 
Published: April 2019

Kotabaru is one of the cultural heritage areas in the city of Yogyakarta which has a high degree of vulnerability to destruction because it is in the central business district. On the other hand, one of the conservation eﬀorts depends on the level of public awareness to preserve it. The younger generation has the potential to support the preservation of cultural heritage. One of the ways is by increasing the awareness of the young generation towards cultural heritage. This activity aims to increase the cultural heritage awareness of the Yogyakarta younger generation in the Kotabaru Cultural Heritage Area. The method is done by means of heritage adventure. The results of this activity show that the level of knowledge and awareness of participants increasing after participating in the activity. They know the history, the characteristic of the building and the conservation eﬀorts. Awareness of cultural heritage is obtained when visiting the Museum Sandi as a form of implementation of preservation and utilization of cultural heritage properly. =================================================================Kotabaru merupakan salah satu kawasan cagar budaya (KCB) di Kota Yogyakarta yang memiliki tingkat kerentanan yang tinggi terhadap perusakan karena berada di kawasan pusat bisnis. Di sisi lain, upaya pelestarian, salah satunya, tergantung pada tingkat kesadaran masyarakat untuk melestarikannya. Generasi muda merupakan kelompok yang berpotensi besar dapat mendukung upaya pelestarian cagar budaya. Salah satunya yaitu dengan meningkatkan kesadaran generasi muda terhadap cagar budaya. Kegiatan ini bertujuan untuk meningkatkan kesadaran generasi muda di Kota Yogyakarta terhadap cagar budaya di Kawasan Cagar Budaya Kotabaru. Metode yang dilakukan adalah dengan kegiatan jelajah wisata heritage. Hasil dari kegiatan ini menunjukkan bahwa tingkat pengetahuan dan kesadaran peserta meningkat setelah mengikuti kegiatan tersebut. Mereka mengetahui sejarah, bentuk bangunan, dan upaya pelestarian yang dilakukan. Pemahaman kesadaran tentang cagar budaya diperoleh ketika mengunjungi Museum Sandi sebagai bentuk implementasi pelestarian dan pemanfaatan cagar budaya dengan baik.
Effect Use of Two Chemical Compounds Sodium Nitrate and Sodium Silicate as Corrosion Inhibitor to Steel Reinforcement
Authors: Mohammed Sarah kareem 
Published: April 2019

Corrosion of steel reinforcement is one of the biggest problems facing all countries in the world like bridges in the beach area and marine constructions which lead to study these problems and apply some economical solutions. According to the high cost of repair for these constructions, were studied the effect of using kind of chemical compounds sodium nitrite(NaNO2) and sodium silicate(Na2SiO3) as corrosion inhibitors admixture for steel bars that immersed partially in electrolyte solution (water + sodium chloride in 3% conc.) (Approximately similar to the concentration of salt in sea water). The two inhibitors above added each one to the electrolyte solution at concentrations (0.5%, 1% and 2%) for both of them.
The results were corrosion rate for steel sample that's immersed partially in salt solution was higher than corrosion rate of steel bar that's immersed partially in electrolyte solution with inhibitors also the two corrosion inhibitors (sodium nitrite and sodium silicate) that added to the electrolyte solution were working successfully to prevent and inhibit the corrosion by using weight loss technique with best percent of 0.5% sodium nitrite ( efficiency 94.1% ) and best percent of 2% sodium silicate ( efficiency 92.5%).
Rádio escola e Educomunicação: um estudo de caso
Authors: Marques Paulo César Pedroza , Borges João José de Santana 
Published: April 2019

O presente artigo tem como objetivo compreender os principais conceitos de uma nova área de conhecimento denominada Educomunicação. Para isso, traz uma breve fundamentação do campo em estudo, evidenciando as principais referências na área, bem como experiências práticas que tenham como base a perspectiva educomunicativa. Dessa forma, será apresentado um estudo de caso realizado em uma escola pública estadual da periferia de Juazeiro-BA, a qual, através de um projeto de rádio escola, alega implementar a Educomunicação.Palavras-chave: Educomunicação. Estudo de caso. Rádio escola.
Gestão de Design relacionada ao processo de Naming
Authors: Veiga Patrick Martinelli , Yamaguchi Adriele Marie , Gomez Luiz Salomão Ribas , Merino Eugenio Andrés Díaz 
Published: April 2019

O presente artigo tem como objetivo relacionar a importância do naming aos níveis de atuação da Gestão de Design. A nomeação torna-se uma questão chave entre linguagem e realidade, uma vez que classifica e organiza a sociedade, conferindo exclusividade a algo, reduzindo o risco de confusão. Neste aspecto, o estudo relativo ao processo de nomeação de marcas, produtos ou serviços, conhecido como Naming, revela-se como um importante objeto de estudo, uma vez que o nome por diversas vezes será uma importante conexão entre as memórias experienciais do público com todo o universo da marca. Como resultado, a pesquisa aponta a relação encontrada entre as temáticas pesquisadas, assinalando como o processo de nomear pode contribuir com cada nível de ação da gestão de design. Deste modo, esta pesquisa se enquadra como exploratória, uma vez que tem como objetivo proporcionar maior familiaridade entre os temas Gestão de Design e Naming.Palavras-chave: Naming. Gestão de Design. Nomes de Marcas. Estratégia em Organizações. Aplicações e Técnicas de Marketing.
Contingências Passivas e Teoria dos Prospectos: Análise dos Efeitos em Indicadores Financeiros de Empresas de Construção Civil e Construção Pesada
Authors: Silva Thaís Alves da , Sanches Simone Letícia Raimundini , Igarashi Deisy Cristina Corrêa 
Published: April 2019

Objetivo: Analisar o efeito dos passivos contingentes nos indicadores econômico-financeiros de empresas dos segmentos de Construção Civil e Construção Pesada listadas na BM&FBovespa da Brasil Bolsa Balcão (B3).Fundamento: A Teoria dos Prospectos assume o pressuposto de que informações sobre perdas possíveis (passivos contingentes) em empresas de construção civil e construção pesada são relevantes na tomada de decisão, pois indicam exposição ao risco de perdas futuras. Método: Análise documental das Demonstrações Contábeis Consolidadas e Padronizadas, do ano de 2016, de 21 empresas de capital aberto do segmento de construção civil e pesada, e utilização do teste de Wilcoxon e teste de McNemar para comparar os indicadores econômico-financeiros antes e após a simulação de provisionamento dos Passivos Contingentes.Resultados: Os Passivos Contingentes divulgados em 2016 podem causar efeitos significativos nos indicadores econômico-financeiros, principalmente nos indicadores de rentabilidade; não influenciam expressivamente o número de empresas com Patrimônio Líquido Negativo; mas provocam aumento significativo no número de empresas com Prejuízo Contábil no período, corroborando a observação de que o saldo de Resultado Líquido de 2016 é sensível ao reconhecimento dos Passivos Contingentes, indicando exposição ao risco de perdas.Contribuições: Contribui para a literatura sobre evidenciação de passivos contingentes e utilidade da informação contábil aos usuários externos no âmbito das Finanças Comportamentais. Contribui também para o estudo e uso dos indicadores financeiros na tomada de decisão a partir de informações que podem ter utilidade preditiva.
Influenza lectura critica
Authors: Herrera Ramírez Diego , Gaus David 
Published: April 2019

Influenza, es una epidemia recurrente en el mundo desde hace varios siglos, a pesar de los esfuerzos médicos cada cierto tiempo se producen epidemias y es un motivo de consulta frecuente en el servicio de Emergencia y Consulta Externa produciendo varias muertes al año en todos los países del planeta.
El conocimiento que tenemos alrededor de esta enfermedad es el que se publica en los países del primer mundo, no contamos con investigaciones grandes en Latinoamérica y este conocimiento nunca es adecuadamente contextualizado.
El objetivo es realizar una revisión bibliográfica sobre el tema y contextualizar este conocimiento para los países tropicales.
METODO
Usamos el método de lectura crítica es la lectura realizada de un modo analítico. Esto significa que además de comprender los que se dice en un texto determinado, se intenta analizar lo expresado para verificar sus aciertos, sus errores y los modos en que se presenta la información. Se buscar tener una visión propia de los hechos presentados, intentando corroborar lo que se afirma con otras fuentes.
Impact of Co-creation Footwear Workshops on Older Women in Elderly Centers in Hong Kong
Authors: Kwan Mei-ying , Yick Kit-lun , Wong Yan-yan 
Published: April 2019

Background: The use of appropriate footwear could reduce the risk of falls among the geriatric population. However, the elderly are generally reluctant to accept new footwear designs particularly with the incorporation of fabrication materials and functional design features that are perceived to be less comfortable. Co-creation activities that encourage user involvement during the product design process and development can therefore address this issue and provide unique benefits and better value for users, increase acceptance, and even lead to positive perception as well as positive psychological impacts, thereby increasing the practical use of newly designed footwear.
Objective: This study aims to investigate the impact of hands-on footwear workshops on perceived functionality of geriatric footwear for older women.
Method: Footwear co-design workshops for older women were carried out in two elderly centers in Hong Kong. Twenty-one healthy females between 64 and 80 years old (mean: 71; SD: 4.2), were recruited. Subjects were invited to decorate the prescribed geriatric footwear prototype and discuss their ideas on footwear design in a group of three. They were surveyed after completing the footwear decoration.
Main outcome measures: The perceptions of the subjects on the geriatric footwear and related design features were analysed.
Results: The questionnaire survey shows positive results in the psychological value of the workshops for older women. The participants express high levels of satisfaction with the co-design process and a strong sense of achievement with the newly designed geriatric footwear. The acceptance and awareness of the functions of the footwear are greatly enhanced.
Conclusions: The co-design approach has positive psychological impacts on the elderly and their acceptance of the final product. This approach also better meets the aesthetic needs of the users.