bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravenous Thrombolysis for Acute Ischemic Stroke After Recent Myocardial Infarction
Authors: Marto João Pedro , Kauppila Linda Azevedo , Jorge Cláudia , Calado Sofia , Viana-Baptista Miguel , Pinho-e-Melo Teresa , Fonseca Ana Catarina 
Published: August 2019

Background and Purpose—
The safety of IV r-tPA (intravenous tissue-type plasminogen activator) for acute ischemic stroke (AIS) treatment after recent myocardial infarction (MI) is still a matter of debate. We studied the safety of delivering IV r-tPA to AIS patients with a MI within the preceding 3 months.

Methods—
Retrospective review of consecutive AIS admitted to 2 tertiary university hospitals’ and systematic literature review for AIS patients with history of MI in the previous 3 months. Patients were divided into 2 groups: treated or not treated with standard IV r-tPA dose for AIS. Cardiac complications (cardiac rupture/tamponade, intracardiac thrombus embolization, or life-threatening arrhythmias) were compared between groups and assessed by type of MI (non–ST-segment–elevation myocardial infarction [STEMI], or STEMI) and time elapsed between vascular events.

Results—

One hundred and two patients were included; 46 (45.1%) were derived from literature review. Median age (interquartile range) was 64 (53–75) years old, and 69 (67.6%) were men. Forty-seven (46.1%) received IV r-tPA. In the treated group, 25 (53.2%) and 23 (48.9%) patients had, respectively, concurrent AIS and MI and STEMI, in comparison with 12 (21.8%;
P
=0.002) and 36 (65.5%;
P
=0.110) patients in the nontreated. Four (8.5%) IV r-tPA–treated patients died from confirmed or presumed cardiac rupture/ tamponade, all with a STEMI in the week preceding stroke. This complication occurred in 1 (1.8%) patients in the nontreated group (
P
=0.178). There were no differences in thrombus embolization (1 [2.1%) versus 2 [3.6];
P
=1.000) and life-threatening arrhythmias (3 [6.4%) versus 7 [12.7];
P
=0.335). No non-STEMI patients receiving IV r-tPA had cardiac complications.

Conclusions—
In patients with AIS and recent or concurrent MI, MI type and the time elapsed between the 2 events should be taken into consideration when deciding to deliver IV r-tPA. Although recent non-STEMI or concurrent events seem safe, STEMI in the week preceding stroke should prompt caution. The low number of events and publication bias may have influenced our conclusions.
Contributions of Stepping Intensity and Variability to Mobility in Individuals Poststroke
Authors: Hornby T. George , Henderson Christopher E. , Plawecki Abbey , Lucas Emily , Lotter Jennifer , Holthus Molly , Brazg Gabrielle , Fahey Meghan , Woodward Jane , Ardestani Marzieh , Roth Elliot J. 
Published: August 2019

Background and Purpose—
The amount of task-specific stepping practice provided during rehabilitation poststroke can influence locomotor recovery and reflects one aspect of exercise dose that can affect the efficacy of specific interventions. Emerging data suggest that markedly increasing the intensity and variability of stepping practice may also be critical, although such strategies are discouraged during traditional rehabilitation. The goal of this study was to determine the individual and combined contributions of intensity and variability of stepping practice to improving walking speed and distance in individuals poststroke.

Methods—
This phase 2, randomized, blinded assessor clinical trial was performed between May 2015 and November 2018. Individuals between 18 and 85 years old with hemiparesis poststroke of >6 months duration were recruited. Of the 152 individuals screened, 97 were randomly assigned to 1 of 3 training groups, with 90 completing >10 sessions. Interventions consisted of either high-intensity stepping (70%–80% heart rate reserve) of variable, difficult stepping tasks (high variable), high-intensity stepping performing only forward walking (high forward), and low-intensity stepping in variable contexts at 30% to 40% heart rate reserve (low variable). Participants received up to 30 sessions over 2 months, with testing at baseline, post-training, and a 3-month follow-up. Primary outcomes included walking speeds and timed distance, with secondary measures of dynamic balance, transfers, spatiotemporal kinematics, and metabolic measures.

Results—

All walking gains were significantly greater following either high-intensity group versus low-variable training (all
P
<0.001) with significant correlations with stepping amount and rate (
r
=0.48–60;
P
<0.01). Additional gains in spatiotemporal symmetry were observed with high-intensity training, and balance confidence increased only following high-variable training in individuals with severe impairments.

Conclusions—
High-intensity stepping training resulted in greater improvements in walking ability and gait symmetry than low-intensity training in individuals with chronic stroke, with potential greater improvements in balance confidence.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT02507466.
Is the Eye Like What It Sees? A Critique of Aristotle on Sensing by Assimilation
Authors: Matthen Mohan 
Published: August 2019

AbstractAristotle held that perception consists in the reception of external sensory qualities (or sensible forms) in the sensorium. This idea is repeated in many forms in contemporary philosophy, including, with regard to vision, in the idea (still not firmly rejected) that the retinal image consists of points of colour. In fact, this is false. Colour is a quality that is constructed by the visual system, and though it is possible to be a realist about colour, it is completely misleading to think of it as received by the retina. Moreover, such supposedly “charitable” interpretations of Aristotle’s doctrines, based on misconceptions of perception-science, distort our understanding of his historical context.
The Juntos Pilot Study: A Diabetes Management Intervention for Latino Caregiving Dyads
Authors: Mendez-Luck Carolyn A. , Miranda Jeanne , Mangione Carol M. , Yoon Jangho , VanGarde Aurora 
Published: August 2019

Purpose The purpose of this study was to design a culturally sensitive dyad-level diabetes intervention to improve glycemic control for older Latino adults with type 2 diabetes. Methods This study used a pretest-posttest noncontrol group design. The intervention was developed from formative research with Mexican-origin caregiving dyads. The curriculum was adapted from 2 randomized trials of community interventions specifically designed for Latino older adults with type 2 diabetes. The curriculum consisted of communication skill-building exercises and dyad decision making on lifestyle changes to improve the older adult’s blood glucose levels. Thirty-two community-dwelling dyads completed a 6-week program of one-on-one sessions with a trained program facilitator. Main outcomes were feasibility and acceptability of the Juntos program. The authors assessed feasibility by examining participant burden and retention and acceptability by participant exit interviews. Although underpowered for outcomes, A1C, health status, and dyadic communication were also assessed to evaluate whether trends suggested the effectiveness of the intervention. Results Most participants viewed Juntos as an acceptable program and wanted the program expanded in terms of length and scope. All outcomes showed improvement from baseline through 6 months postintervention. Conclusions Results show that Juntos is acceptable to Mexican-origin caregiving dyads and is a promising approach for effectively controlling type 2 diabetes among older Latino adults who have a family caregiver.
Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies
Authors: Ari Aziz , Tatar Cihad , Yarikkaya Enver 
Published: August 2019

Objective Helicobacter pylori commonly occurs in the stomach, but localizations outside the stomach and related diseases have also been investigated. However, the relationship between H. pylori and gallstones remains controversial. We aimed to investigate the relationships between H. pylori in the stomach and the gallbladder and gallstones. Methods This prospective case-control study included patients who underwent cholecystectomy because of gallstones, pancreatic head cancer, or hepatic resection. The patients were separated into two groups according to the detection of H. pylori in gallbladder samples using Giemsa staining. Stomach H. pylori status was based on previous gastroscopy. Results The study enrolled 60 patients, comprising 27 patients with gallstones and 33 without. There was no significant difference in the incidence of gallstones between patients with or without H. pylori in the stomach or gallbladder. Furthermore, the presence of H. pylori in the stomach was measured in 14 patients and was significantly correlated with H. pylori in the gallbladder. Conclusion The current study showed no relationship between the occurrence of gallstones and the presence of H. pylori in either the gallbladder or the stomach. In contrast to previous reports, this suggests that H. pylori does not play a role in the development of gallstones.
Radiographic Assessment of First Tarsometatarsal Joint Shape and Orientation
Authors: Koury Kimberly , Staggers Jackson R. , Pinto Martim C. , Godoy-Santos Alexandre L. , Smyth Niall A. , Shah Ashish B. , de Cesar Netto Cesar 
Published: August 2019

Background: Hypermobility within the first tarsometatarsal (TMT) joint is a predisposing factor for hallux valgus. The purpose of this study was to assess whether the shape and angulation of the first TMT joint are affected by the positioning of the foot in radiographs. Methods: Ten adult above-knee fresh-frozen cadaveric specimens were placed into a radiolucent apparatus that allowed controlled angulation of each foot at 0, 5, 10, 15, and 20 degrees in dorsiflexion, plantarflexion, inversion, and eversion. For each specimen, the first TMT joint angle (1TMTJA), shape of the distal articular surface of the medial cuneiform (flat or curved), and image quality of the first TMT joint were measured. Results: The mean value for 1TMTJA was 22.9 degrees (95% confidence interval [CI] 21.9-24). Individual anatomical variations of the specimens as well as the different angulations due to foot positioning significantly influenced the 1TMTJA (both P < .001). Joints that were found to have a flat configuration showed significantly increased 1TMTJA on average when compared to the ones with curved articular surface, 25.9 (95% CI 24.4-27.4) and 20.8 degrees (95% CI 19.5-22.0) ( P < .001), respectively. Image quality for visualization of the first TMT joint was progressively better for increased angles of dorsiflexion and inversion. Conclusion: The shape and angulation of the first TMT joint on radiographic evaluation are affected by the positioning of the foot. Clinical Relevance: Clinical usefulness of these radiographic characteristics is limited and should not influence operative planning in patients with possible instability of the first TMT joint.
Preliminary Experience With a Minimally Invasive Technique for Hallux Valgus Correction With No Fixation
Authors: Lucattelli Giuseppe , Catani Ottorino , Sergio Fabrizio , Cipollaro Lucio , Maffulli Nicola 
Published: August 2019

Background: Percutaneous operative techniques for hallux valgus (HV) correction are less damaging to soft tissues and the first metatarsophalangeal joint, and they carry a lower risk of wound complications. We report our preliminary results using a percutaneous technique that allowed correction of the deformity without internal fixation. Methods: One hundred ninety-five consecutive patients with isolated symptomatic HV were surgically treated using a percutaneous technique without any form of internal fixation, with a mean follow-up of 34.6 months. The American Orthopaedic Foot & Ankle Society (AOFAS) hallux-metatarsophalangeal-interphalangeal scale score was used for clinical assessment. Radiographic evaluation included pre- and postoperative assessment of the hallux valgus angle (HVA), intermetatarsal angle (IMA), distal metatarsal articular angle (DMAA), and sesamoid position in weightbearing radiographs. Results: According to the AOFAS score, the patients improved from a preoperative median of 54.7 to 89.6 at 2 years’ follow-up ( P = .002). Patients were satisfied or very satisfied in 94% of cases at the latest follow-up. A mean radiographic correction of the HVA of 15.5 degrees, of the IMA of 5.4 degrees, and of the DMAA of 5.4 degrees was achieved. The AOFAS global score and every individual parameter improved significantly between pretreatment and latest follow-up ( P > .01). A total of 19 (9.7%) complications were reported. Conclusion: This percutaneous technique, which did not use any form of internal fixation described, produced durable results for the correction of HV, reliably correcting the deformity and resulting in significant improvement in function and decrease of pain. Level of Evidence: Level IV, retrospective case series.
Retrieval strategy for ruptured balloon with circumferential tear during angioplasty for arteriovenous fistula in hemodialysis patients
Authors: Murata Ryohei , Kamiizumi Yo , Haneda Tsutomu , Ishizuka Chihiro , Kashiwakura Sayuri , Tsuji Takeshi , Kasai Hironori , Tani Yasuhiro , Inagaki Naoto , Chiba Satoshi , Ito Koji 
Published: August 2019

Introduction: Balloon angioplasty is a common endovascular procedure. The balloon for angioplasty sometimes ruptures (incidence, 3.6%–10%), and it is constructed such that it ruptures in a longitudinal direction and complications related to rupture are rare. However, on rare occasions, retrieval is challenging, especially in the case of ruptures with a circumferential tear. There is no established method for retrieval and careful retrieval is required due to the risk of embolization by the residual balloon fragment. Technique: We describe two cases of balloon rupture in the transverse direction during percutaneous transluminal angioplasty for arteriovenous fistula in hemodialysis patients. In these cases, the balloon ruptured with a circumferential tear and dissected into two parts, and the tip edge remained in the vessel. We inserted an additional introducer at the side of the tip edge, caught the guidewire by a gooseneck snare, and hooked the residual balloon fragment. This also stabilized and increased the stiffness of the guidewire through the “pull-through technique.” Then, we reintroduced the gooseneck snare to catch the residual balloon. We then inserted a cobra-head catheter from the first introducer and pushed the residual balloon. We finally retrieved the ruptured balloon by pulling back the gooseneck snare and pushing using the cobra-head catheter simultaneously. Results: We could retrieve the ruptured balloons successfully using this technique and percutaneous transluminal angioplasty was continued in both cases. Conclusion: Our technique of retrieval may be suitable for cases of balloon rupture with a circumferential tear during percutaneous transluminal angioplasty. The technique enables less invasive retrieval and continuation of the percutaneous transluminal angioplasty thereafter.
Commissioning and Evaluation of a Third-Party 6 Degrees-of-Freedom Couch Used in Radiotherapy
Authors: Chan Maria F. , Lim Seng-Boh , Li Xiang , Tang Xiaoli , Zhang Peng , Shi Chengyu 
Published: August 2019

Purposes: The newly released Protura 6 degrees-of-freedom couch (CIVCO) has limited quality assurance protocols and pertinent publications. Herein, we report our experiences of the Protura system acceptance, commissioning, and quality assurance. Methods: The Protura system integration was tested with peripheral equipment on the following items: couch movement range limit, 6 degrees-of-freedom movement accuracy, weight test and couch sagging, system connection with Linac, isocentricity of couch and rotation alignment, kV and cone-beam computed tomography imaging of HexaCHECK with MIMI phantom (Standard Imaging), and an in-house custom 6 degrees-of-freedom quality assurance phantom. A couch transmission measurement was also performed. Results: The vertical, longitudinal, and lateral ranges of the 6 degrees-of-freedom couch pedestal are 43.9 to 0.0 cm, 24.6 to 149.5 cm, −20.6 to 20.7 cm, respectively. The couch movement accuracy was within 1 mm in all directions. The couch sagging with a 200 lbs (∼91 kg) evenly distributed object is 1.0 cm and 0.4° pitch in the distal end of the couch. The isocentricity of the couch was about 0.5 mm in diameter of all crosshair projections on the couch isocenter level, and the largest couch rotation alignment observed was (0.3°) at the couch angle of 90°. The deviation from the reference position (zero position) of the HexaCHECK phantom, measured by matching the cone-beam computed tomography with the reference planning computed tomography, was found to be below 0.2 mm in the anterior–posterior and right–left dimensions, 0.4 mm in superior–inferior dimension, and 0.1° in roll, pitch, and yaw directions. Conclusions: A 6 degrees-of-freedom quality assurance phantom is helpful for the commissioning and routine quality assurance tests. Due to the third-party integration with Linac, the system is prone to “double-correction” errors. A rigorous quality assurance program is the key to a successful clinical implementation of the Protura system.
Outcome of Distal Biceps Tendon Repair With and Without Concomitant Bicipital Aponeurosis Repair
Authors: Conlin Catherine Ellen , Naderipour Alireza , ElMaraghy Amr 
Published: August 2019

Background: The bicipital aponeurosis (BA) can often be torn concomitantly with a distal biceps tendon (DBT) rupture. Its repair, although recommended by some, has not commonly been addressed during the surgical management of DBT ruptures, and to date, surgical repair of the BA with DBT repair has not been evaluated clinically. Purpose: To utilize subjective and objective outcome measures to examine the safety and efficacy of 2-incision DBT repair with and without repair of the BA in patients with a DBT rupture. Study Design: Cohort study; Level of evidence, 3. Methods: Demographic and surgical data were reviewed retrospectively. Patients returned to the clinic to complete subjective outcome measures and objective measurements of range of motion, strength, and biceps contour. All patients were evaluated at least 1 year after surgical treatment. Results: Data from 24 male patients with a DBT rupture were used for the analysis; 13 (54%) underwent concomitant DBT and BA repair, and 11 (46%) underwent isolated DBT repair. There were no complications at 1 year in either group. The DBT + BA repair group returned to recreational activities faster (77% within 6 months and 100% within 1 year) than the isolated DBT repair group (36% within 6 months, 91% within 1 year, and 100% after more than 2 years) ( P = .05). There was a trend toward better Patient-Rated Elbow Evaluation pain scores in the DBT + BA repair group than in the isolated DBT repair group (1.2 vs 5.3, respectively; P = .18). A trend also emerged toward closer return to subjective preinjury strength (77% vs 44%, respectively; P = .14). No significant difference emerged in patient satisfaction with the biceps contour, subjective scores on functional activities and disability, or objective measurements of strength, contour, and range of motion. Conclusion: This pilot study suggests that repair of the BA in conjunction with DBT repair leads to a faster return to recreational activities compared with isolated DBT repair. Also noted was a trend toward subjectively improved pain and greater perceived strength, after DBT + BA repair, although this was not statistically significant. Further investigation with a larger population is required to better elucidate these potential differences.
Mechanistic Insights into Methane Oxidation by Molecular Oxygen under Photoirradiation: Controlled Radical Chain Reactions
Authors: Hori Yuta , Abe Tsukasa , Shiota Yoshihito , Yoshizawa Kazunari 
Published: August 2019

Abstract
The selective oxidation of CH4 using O2 is one of the most attractive subjects as an elusive target reaction. Ohkubo and Hirose recently reported that chlorine dioxide radical (ClO2•), which is generated by mixing NaClO2 and HCl in an aqueous solution, acts as an efficient oxidant in the oxidation of CH4 to CH3OH and HCOOH under photoirradiation in the two-phase system of perfluorohexane and water (Angew. Chem., Int. Ed. 2018, 57, 2126). The reaction system gives CH3OH and HCOOH without further oxidation products. They proposed that methoxy radical (CH3O•) plays an important role as an intermediate in the oxidation of CH4. In the present work, we focus on the reactivity of CH3O• to CH4 in detail to propose a reasonable radical mechanism for the oxidation of CH4 using DFT calculations at the M06-2X/6-311+G** level of theory and UCCSD(T)/6-311+G** calculations. Our reaction analysis suggests that the reaction of CH3O• with CH4 and the disproportionation of CH3O• take place as CH4 + CH3O• → CH3• + CH3OH and 2CH3O• → CH3OH + HCHO, respectively. In contrast, the isomerization from CH3O• to CH2•(OH), suggested by Ohkubo and Hirose, is unlikely to occur under ambient conditions, due to the high activation barrier for this reaction. A better understanding of the well-controlled radical chain reactions is useful for reaction design of the hydroxylation of methane.
Diet Quality Is Associated with Physical Performance and Special Forces Selection
Authors: FARINA EMILY K. , THOMPSON LAUREN A. , KNAPIK JOSEPH J. , PASIAKOS STEFAN M. , LIEBERMAN HARRIS R. , MCCLUNG JAMES P. 
Published: August 2019

ABSTRACT

Purpose
This study determined associations between diet quality measured by the Healthy Eating Index (HEI)-2015, physical performance, and successful selection following a U.S. Army Special Forces Assessment and Selection course characterized by arduous cognitive and physical demands.

Methods
The HEI-2015 scores were calculated from usual diet assessed with a Block food frequency questionnaire among 782 soldiers attending Special Forces Assessment and Selection. Differences in HEI-2015 scores according to demographics and physical performance were determined with analysis of variance. Differences in likelihood of selection according to HEI-2015 scores were determined with logistic regression. Models were adjusted for potential confounders: age, education, body mass index (BMI), duration and type of resistance training, and smoking.

Results
The HEI-2015 total score was higher among older soldiers (≥25 yr), those with more education (≥some college), higher body mass index (≥25), longer duration of resistance training (≥400 min·wk−1), those that reported use of free weights, suspension training, Olympic lifting, and nonsmokers (P < 0.05). The HEI-2015 total score was higher among those with higher Army Physical Fitness Test (APFT) total scores, APFT sit-up score, APFT run score, and faster loaded road march times (P < 0.05). Those with higher HEI-2015 total scores were 75% (quartile 3 vs quartile 1: odds ratio, 1.75; 95% confidence interval, 1.09–2.81) and 65% (quartile 4 vs quartile 1: odds ratio, 1.65, 95% confidence interval, 1.03–2.65) more likely to be selected. Higher scores for total vegetables, greens and beans, seafood and plant protein, and refined grains, but lower sodium scores (indicating more sodium consumed), were associated with better physical performance (P < 0.05).

Conclusions
Dietary patterns that conform to federal dietary guidelines (except sodium) are associated with physical performance and Special Forces selection.