bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Genetic Variants with Colorectal Cancer in the Extended MENA Region: A Systematic Review
Authors: Sidenna Mariem , Bux Reem , Fadl Tasnim , Ozbek Ugur , Zayed Hatem 
Published: October 2019

Background:
Colorectal cancer (CRC) is the third most common cancer
worldwide and the third leading cause of cancer-related death. It is a heterogeneous
disease that develops through different genetic and epigenetic mechanisms. To date, no
comprehensive systematic review investigating genetic risk factors for familial and
sporadic CRC has been performed on the extended MENA (eMENA) region.

Aims:
This study aimed to systematically analyze genetic variations significantly
associated with CRC in the eMENA region.

Methods:
We searched four literature databases (PubMed, Scopus, Science Direct, and
Web of Science) from the time of inception until May 2019 using broad search terms to
obtain all reported genetic data related to eMENA patients with CRC. Variants with an
OR>1 that are associated with CRC were identified.

Results:
A total of 1,200 studies were obtained from our search method, 27 of which
met the inclusion criteria for our systematic review, with a total of 8,230 CRC patients
and 7,611 controls. Of these, 1,941 patients distributed throughout nine eMENA
countries were found to carry 46 variants in 33 different genes. Interestingly, 19 variants
were unique to CRC patients in the eMENA region.

Interpretation:
This is the first systematic review to capture the spectrum of variants
significantly associated with CRC in the eMENA region. There appears to be a
distinctive clinical picture for eMENA patients with CRC, and the range and distribution
of variants among patients from the eMENA region differ from those noted in other
ethnic groups.
Evaluation of Tissue and Serum Expression Levels of Lactate Dehydrogenase Isoenzymes in Patients with Head and Neck Squamous Cell Carcinoma
Authors: Mohtasham Nooshin , Ayatollahi Hossein , Saghravanian Nasrollah , Zare Reza , Shakeri Mohammad-Taghi , Sahebkar Amirhossein , Mohajertehran Farnaz 
Published: October 2019

Background:Head and Neck Squamous Cell Carcinoma (HNSCC) is a common malignancy that is associated with high morbidity and mortality all over the world. We explored the role of mRNA expression of both subunits of LDH in the early diagnosis of HNSCC.Materials and Methods:This was a case-control study on 62 healthy individuals and 62 patients with HNSCC. The expression of LDH in tumors and healthy tissue margins, and in the serum of both HNSCC patients and healthy individuals was evaluated using a quantitative real-time PCR method. Analysis of LDH-A and LDH-B expression and sensitivity-specificity analysis were carried out using SPSS software.Results:mRNA expression levels of LDH-A (4.18±1.29) and LDH-B (2.85±1.07) isoenzymes in tumor tissues were significantly higher than the expressions in the corresponding healthy tissue margins (1.85±0.56 and 1.61±0.56 for LDH-A and LDH-B, respectively). A comparison of LDH-B expression between histological grade I tumor tissue (2.74±0.19) and marginal tissue (1.62±0.90) showed a significant difference (P=0.016). Patients with a positive history of alcohol consumption and cigarette smoking had significantly higher mRNA expression of LDH-A (P=0.024) and LDH-B (P=0.03) in the marginal tissue and blood, respectively. The highest sensitivity and specificity values pertained to the mRNA expression of LDH-A (90.9%) and LDH-B (85.5%) in the blood.Conclusion:This is the first study reporting LDH gene expression as a biomarker in blood and tumoral tissue of HNSCC patients. Given the highest sensitivity and specificity values for LDH-A and LDH-B in blood, we recommend the simultaneous evaluation of both LDH isoenzymes in blood samples as a potential diagnostic method.
A New Tool for Simulation of Single Electron Transistor based Microprocessor Using Vector File
Authors: Patel Rashmit , Agarwal Yash , Parekh Rutu 
Published: October 2019

Background:
A microprocessor is a general-purpose device, which works on the user
defined instructions. The design of next generation microprocessors demands high speed, high
density and low power requirements that can be attained by prominent device like Single Electron
Transistor (SET).

Methods:
Based on realizable SET parameters at room temperature and 800 mV operating voltage;
an 8-bit SET based microprocessor is designed and simulated using Cadence Virtuoso environment.
The simulation of the microprocessor requires complex stimuli to verify the design for
multiple instructions. Conventionally, the simulation is performed by applying individual signal
source to each signal. However, that is not optimum and viable for microprocessor designs.

Results:
The Cadence Spectre simulator has a facility to simulate the design using vector file,
which combines multiple signal sources in a text file. In addition, writing vector file manually is
complex and erroneous.

Conclusion:
To overcome the problem, a tool is designed and developed that generates a vector
file for user selected instructions and parameters. The usage of vector file makes the simulation
straightforward and accurate. This paper describes the design of a tool for vector file generation.
Pengaruh Kecepatan dan Kedalaman Potong pada Proses Pembubutan Konvensional Terhadap Kekasaran Permukaan Lubang
Authors: Siswanto Bambang , Sunyoto Sunyoto 
Published: October 2019

There are several factors that affect the roughness of the workpiece surface when doing turning process on the lathe, especially the use of cutting parameters. This study aims to determine the effect of cutting speed and depth of cut parameters on the roughness of cylinder block hole surface. This research is an experimental research using two independent variables, which are cutting speed and depth of cut. The dependent variable is surface roughness of cylinder block’s hole. The research was done by making cast aluminum specimens and then turning a hole in the specimen with varied cutting speed and depth of cut. The surface roughness was then tested using Surfcorder SE 300. The obtained data were analyzed using descriptive analysis. Results show that there is an effect of cutting speed on the surface roughness of cylinder block, with the best result (smallest roughness value) was obtained from the use of cutting speed of 125 m / min. There is also an effect of depth of cut on the surface roughness of the cylinder block, with the best result given from the use of a 0.2 mm depth of cut.Ada beberapa faktor yang mempengaruhi tingkat kekasaran permukaan benda kerja pada proses pembubutan. Penelitian ini bertujuan untuk mengetahui pengaruh parameter kecepatan potong dan kedalaman potong terhadap kekasaran permukaan pada pembubutan lubang blok silinder mesin pemotong rumput. Penelitian ini merupakan penelitian eksperimen dengan variabel bebas kecepatan potong dan kedalaman potong, dan variabel terikat kekasaran permukaan lubang. Penelitian dilakukan dengan pembuatan spesimen dengan proses pengecoran aluminium kemudian spesimen dibubut lubang dengan diberi variasi kecepatan potong dan variasi kedalaman potong. Hasil pembubutan dilakukan uji kekasaran menggunakan Surfcorder SE 300. Data yang diperoleh kemudian dianalisis dengan analisis deskriptif. Hasil penelitian menunjukkan bahwa ada pengaruh kecepatan potong terhadap hasil kekasaran permukaan blok silinder mesin pemotong rumput, hasil paling baik dengan nilai kekasaran paling kecil diperoleh dari kecepatan potong 125 m/menit. Ada pengaruh kedalaman potong terhadap hasil kekasaran permukaan blok silinder mesin pemotong rumput, hasil paling baik dengan nilai kekasaran paling kecil diperoleh dari kedalaman potong 0,2 mm.
Pengaruh Praktik Industri Terhadap Hard Skill Siswa SMK pada Program Keahlian Teknik Pemesinan
Authors: Prasetyo Yudha Dwi , Tiwan Tiwan , Soemowidagdo Arianto Leman 
Published: October 2019

The implementation of industrial practices is expected to improve skills, verbal abilities, and can provide creative ideas for students in developing skills that have been raised to create the right innovation. This research aims to determine the implementation of industrial attachment for the students of machining study program, and the influence of industrial attachment on the students’ hard skill. This research used ex-post facto method with a quantitative approach. The subjects were class XII students of machining study program with a total sample of 98 students. Data were collected using questionnaire and documentation. Data were analyzed using Pearson’s product moment correlation and simple regression analysis. Results show that the implementation of industrial attachment for students of machining study program is categorized as ‘high’ (69,38% in average), and that there is as a positive and significant effect on the students’ hard skill.Pelaksanaan praktik industri diharapkan mampu meningkatan keterampilan, kemampuan verbal, dan dapat memberikan ide-ide kreatif bagi siswa dalam mengembangkan keterampilan yang telah dimilikinya untuk membuat inovasi produk tepat guna. Penelitian ini bertujuan untuk mengetahui keterlaksanaan praktik industri siswa Teknik Pemesinan, dan pengaruh praktik industri terhadap hard skill siswa. Penelitian ini menggunakan metode ex-post facto dengan pendekatan kuantitatif. Subyek penelitian adalah siswa kelas XII program keahlian Teknik Pemesinan dengan jumlah sampel 98 siswa. Metode pengumpulan data dengan metode kuesioner dan dokumentasi. Teknik analisis data menggunakan teknik korelasi product moment dari Pearson dan dilakukan uji analisis regresi sederhana. Hasil penelitian menunjukkan bahwa keterlaksanaan praktik industri siswa teknik pemesinan rata-rata temasuk kedalam kategori tinggi 69,38%, dan praktik industri berpengaruh positif dan signifikan terhadap hard skill siswa. Hubungan yang diperoleh adalah semakin tinggi tingkat pelaksanaan praktik industri, maka semakin tinggi pula hard skill-nya dan bidang pekerjaan memiliki pengaruh tinggi terhadap nilai praktik industri siswa teknik pemesinan
Perbandingan Penggunaan Filter Udara Standar dan Racing Terhadap Performa dan Emisi Gas Buang Mesin Sepeda Motor Empat Langkah
Authors: Fatkhuniam Agus , Wijaya M. Burhan Rubai , Septiyanto Angga 
Published: October 2019

This research aims to determine the performance increase of using racing air filters compared to standard air filters on a four-stroke vehicle. Performance being tested are power, torque and exhaust emissions. This is an experimental research conducted on a Honda Supra X 125 PGM-FI motorcycle. Data were analyzed using descriptive statistics and the collection is presented in the form of tables, graphs, and calculated averages. Results show that racing air filter 1 have a power of 7.35 HP (2.3% increase) and racing air filter 2 have a power of 7,3 HP (1.6% increase). The torque tests shows that Racing filter 1 has a torque of 10,588 Nm and the racing air filter 2 has a torque of 10,585 Nm, while standard filter has only 10.42 Nm. CO gas emissions resulting from the use of racing air filters 1 increased by 28% from standard air filters and for racing air filter 2 CO 2 emissions decreased by 6%. At the exhaust emissions of HC, racing air filters 1 emissions increased by 16% and racing air filter 2 decreased by 9%. Penelitian ini bertujan untuk membuktikan adanya perbedaan filter udara racing dengan filter udara standar terhadap performa kendaraan empat langkah, berupa daya, torsi dan emisi gas buang. Penelitian dilakukan secara eksperimen pada sepeda motor Supra X 125 PGM-FI. Analisis data menggunakan statistik deskriptif dengan penyajian data berupa tabel, grafik. Hasil penelitian menunjukkan bhawa perhitungan rata-rata. sebesar 7,35 Hp dengan meningkat 2,3% dan filter udara racing 2 meningkat sebesar 1,6 % menjadi 7,3 HP dibandingkan dari hasil filter udara standar sebesar 7,18 Hp, torsi filter udara racing 1 meningkat sebesar 1,6% menjadi 10,588 N.m dan filter udara racing 2 meningkat 1,5% menjadi 10,585 N.m dibandingkan hasil dari penggunaan filter standar sebesar 10,42 N.m. Emisi gas buang CO yang dihasilkan dari penggunaan filter udara racing 1 meningkatan 28% dari filter udara standar 0,803% menjadi 1,034% dan CO filter udara racing 2 ada penurunan 6% menjadi 0,754% dari CO filter udara standar 0,803%, dengan selisih perbedaan 0,231% dan 0,049% dari penggunaan filter udara standar. Pada emisi gas buang HC filter udara racing 1 terdapat peningkatan sebesar 16% menjadi 142 ppm dari hasil filter standar dan penurunan 9% dari penggunaan filter udara racing 2 sebesar 111 ppm dibandingkan HC yang dihasilkan filter standar sebesar 122 ppm, dengan selisih 20 ppm dan 11 ppm dari HC yang dihasilkan filter udara standar.
Esensi Lesson Study di Era 4.0
Authors: Ratnawati Dianna 
Published: October 2019

Collaborative and sustainable actions carried out by a group of teachers/lecturers through lesson study with an information and communication technologies approach can meet the needs of the world of education in era 4.0. This study aims to analyze the impact of the application of lesson study in learning activities on the technical measurement on mechanical engineering students of the Universitas Sarjanawiyata Tamansiswa. The research method uses lesson research with a qualitative approach. The applied lesson study model adopts Saito et al. (2005), in which its implementation consists of 2 cycles, each cycle includes the stages of the plan, do, and see. The learning media used are a digital book, e-learning using Edmodo, Toyota 7k engine stand, handphone, cylinder block, clutch, differential, dial gauge, cylinder gauge, vernier caliper, and micrometer. The sample selected amounted to 30 students and involved two observers in each cycle. The results of this study indicate that the essence of lesson study has an impact on increasing student activity by 40% in cycle 1 and 34% in cycle 2. The lesson study also has an effect on improving the quality of the lecturer’s evaluation on the students’ learning outcomesTindakan kolaboratif dan berkelanjutan yang dilakukan sekelompok guru/dosen melalui lesson study dengan pendekatan information and communication technologies dapat memenuhi kebutuhan dunia pendidikan di era 4.0. Penelitian ini bertujuan untuk menganalisis dampak penerapan lesson study dalam kegiatan pembelajaran pengukuran teknik pada mahasiswa pendidikan teknik mesin Universitas Sarjanawiyata Tamansiswa. Metode penelitian menggunakan lesson research dengan pendekatan kualitatif. Model lesson study yang diterapkan mengadopsi dari Saito dkk (2005), dimana dalam pelaksanaannya terdiri dari 2 siklus dengan tahapan tiap siklusnya meliputi plan, do, dan see. Media pembelajaran yang digunakan adalah digital book, e-learning melalui edmodo, engine stand toyota 7k, handphone, blok silinder, kopling, gardan, dial gauge, cylinder gauge vernier celiper dan mikrometer. Sampel yang dipilih berjumlah 30 mahasiswa dengan melibatkan 2 observer pada tiap siklusnya. Hasil penelitian ini menunjukkan bahwa esensi lesson study berdampak pada peningkatan keaktifan siswa sebesar 40% pada siklus 1 dan meningkat 34% pada siklus 2, selain itu berdampak pada peningkatan kualitas evaluasi dosen terhadap hasil belajar mahasiswa
Internet-Based Sharing Nurse Program and Nurses’ Perceptions in China: Cross-Sectional Survey (Preprint)
Authors: Huang Rendong , Xu Mei , Li Xiuting , Wang Yinping , Wang Bin , Cui Naixue 
Published: October 2019

BACKGROUND

China is currently piloting a “Sharing Nurse” program that aims to increase the accessibility of nursing services to at-home patients by enabling patients to order nursing services using mobile apps or online platforms.

OBJECTIVE

This study aims to assess nurses’ perceptions of the Sharing Nurse program, including their acceptance, concerns, needs, and willingness to take part in the program.

METHODS

A total of 694 nurses participated in the questionnaire survey. The survey collected their sociodemographic and work-related information and their perceptions of the Sharing Nurse program using a self-developed questionnaire.

RESULTS

The 694 respondents agreed that the Sharing Nurse program could provide patients with better access to nursing care (n=483, 69.6%). Their main concerns about the program were unclear liability division when medical disputes occur (n=637, 90.3%) and potential personal safety issues (n=604, 87%). They reported that insurance (n=611, 88%), permits from their affiliated hospital (n=562, 81.0%), clear instructions concerning rights and duties (n=580, 83.6%), real time positioning while delivering the service (n=567, 81.7%), and one-key alarm equipment (n=590, 85.0%) were necessary for better implementation of the program. More than half of the respondents (n=416, 60%) had an optimistic attitude toward the development of the Sharing Nurse program in China. However, only 19.4% (n=135) of the respondents expressed their willingness to be a “shared nurse.” Further analyses found that nurses with a master’s degree or above (χ<sup>2</sup><sub>3</sub>=28.835, <i>P</i>&lt;.001) or from tertiary hospitals (χ<sup>2</sup><sub>3</sub>=18.669, <i>P</i>&lt;.001) were more likely to be aware of the Sharing Nurse program and that male nurses were more willing to be shared nurses (<i>Z</i>=–2.275, <i>P</i>=.02).

CONCLUSIONS

The Chinese Sharing Nurse program is still in its infancy and many refinements are needed before it can be implemented nationwide. Generally, Chinese nurses are positive about the Sharing Nurse program and are willing to participate if the program is thoroughly regulated and supervised.
Solución y análisis del modelo de Södergren para celdas solares tipo Grätzel usando la función Solver de Excel
Authors: Alfaro Guerra Marco Antonio , Alfaro Alcaino Ignacio Antonio , Guerra Rojas Rodrigo Alejandro 
Published: October 2019

<p>La simulación de experimentos es un aspecto que ha cobrado interés en el último tiempo en la enseñanza de la Química en los casos donde no se disponga de reactivos o del equipo necesario para la realización de éstos. Excel es un programa informático desarrollado y distribuido por Microsoft Corp. que permite realizar tareas contables y financieras mediante hojas de cálculo, forma parte de Microsoft Office y es utilizado en gran parte del mundo. Permite realizar muy diversas operaciones e incluye el complemento Solver. Con este complemento es posible el ajuste de datos experimentales utilizando funciones lineales y no lineales. Modelos no lineales permiten la simulación de las curvas corriente voltaje de celdas solares tipo Grätzel. Este tipo de experiencias le permiten al alumno integrar conocimientos de Fisicoquímica con conocimientos de Matemáticas y Computación.</p>
Fordelingspolitikkens nye ånd – om mulighederne for kritik i konkurrencestaten
Authors: Didia Jensen Jacob 
Published: October 2019

Med sin introduktion af begrebet ’konkurrencestat’ i en dansk kontekst tilbød Ove Kaj Pedersen et nyt teoretisk perspektiv på, hvordan den universelle danske velfærdsstat i et vist omfang er blevet erstattet af en neoliberal konkurrencestat baseret på markedstænkning. I denne artikel forsøger jeg at udbygge denne forståelse af konkurrencestaten ved at analysere udviklingen i Danmark fra velfærdsstat til konkurrencestat ved hjælp af Boltanski og Chiapellos teori om kapitalismens nye ånd. Igennem denne analyse søger jeg for det første at vise, at de værdier, som konkurrencestaten henviser til, når den retfærdiggør sin fordelingspolitik, ikke kun kan forstås som udtryk for markedstænkning. De må også i høj grad forstås som udtryk for idealiseringen af fleksibilitet, kreativitet og inklusion i arbejdsnetværk, som Boltanski og Chiapello identificerer som centrale i kapitalismens nye ånd, og som har rødder i venstrefløjens kapitalismekritik. For det andet er formålet med artiklen at diskutere, hvilke negative konsekvenser idealiseringen af fleksibilitet og omstillingsparathed samt det store fokus på kontinuerligt at opkvalificere borgere kan risikere at have for borgere og offentligt ansattes mulighed for at forholde sig kritisk til konkurrencestatens moralske legitimitet.

ENGELSK ABSTRACT Jacob Didia Jensen: The new spirit of allocation policy With his introduction of the concept ‘competition state’ in Denmark, Ove Kaj Pedersen offered a new perspective on how the universal Danish welfare state has been partially replaced by a neoliberal competition state based on market logic. In this article, I seek to expand this idea of the competition state by analysing the Danish development from welfare state to competition state through Boltanski and Chiapello’s theory of a new spirit of capitalism. In this analysis, I seek to show, firstly, that the values used by the competition state to justify its allocation policy cannot only be understood as an expression of market logic. They must also to be understood as expressions of the idealisation of flexibility, creativity and inclusion in work-based networks, that Boltanski and Chiapello identify as central in the new spirit of capitalism, and which have roots in the left-wing critique of capitalism. Secondly, the article discusses how negative consequences the idealisation of flexibility, adaptability and the focus on continuously upgrading the skills of citizens in order to ensure their inclusion on the labour market impact on the ability of citizens and public employees to critically reflect on the moral legitimacy of the competition state. Keywords: competition state, allocation policy, justification, critique, new spirit of capitalism, Boltanski and Chiapello
IbM TUNA NETRA SUDARNO DAN SUPARDIONO DI KARANGANYAR
Authors: Herawati Isnaini , Wahyuni Wahyuni 
Published: October 2019

Today, a massage parlors have developed, including massage parlors by blind people. In Karanganyar, there are 9 massage parlors done by blind people under PERTUNI (Society for the Blind Indonesia), and the number was not included in the outposts or sub-districts in Karanganyar. There are two business units that will be a partner, namely Mr. Sudarno and Mr. Supardiono. This community service aims to increase the number of customers and to improve the quality of the Blind Massage services Sudarno and Supardiono. Activities that have been implemented are: the observation of the partners’ needs, fulfilling the needs of partners, training on massage and aromatherapy, and improve promotional partner with signboards at strategic places. Partner 1 already has 3 pieces adequate massage booths, even one cubicle equipped with air conditioning. The first partners are still in need of help for marketing. Partner 2 requires repair his massage booths so as to provide convenience for customers.
PEMANFAATAN BAHAN ALAMI UNTUK PENGEMBANGAN PRODUK ECOPRINT DI DUKUH IV CERME, PANJATAN, KABUPATEN KULONPROGO
Authors: Saptutyningsih Endah , Wardani Dyah Titis Kusuma 
Published: October 2019

The Community Partnership Program aimed to provide direct benefits to people's lives in the social and economic fields and to improve the quality of resources through the empowerment of the women of the PKK and Karang Taruna groups in Dukuh IV Cerme, Panjatan, Kulon Progo Regency by utilizing natural ingredients in around his residence. This activity was expected to solve the problems in the partner villages, namely the source of income for the community is only dominated by the agricultural sector, the natural potential of the village that has not been used properly, lack of skills in managing the potential of the village, the majority of the residents of Dukuh VI Cerme are housewives who have minimal income. The Community Partnership Program consists of two activities, namely the training in making ecoprints by utilizing natural materials in the neighborhood around Dukuh VI Cerme, Panjatan and making audio-visual videos on how to make ecoprints. The Partnership Program activity is expected to be carried out continuously so that it can be an additional livelihood for the local community because the selling value of the ecoprint product is still quite high on the market. Keywords: Ecoprint; Income; Natural Ingredient; Kulonprogo