bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upregulation of FGFR3 and HIF-1α expression in muscle invasive bladder cancer
Authors: Warli Syah Mirsya , Laksmi Lidya Imelda , Safriadi Ferry , Umbas Rainy 
Published: May 2019

BACKGROUND The major risks in patients diagnosed with non-muscle invasive bladder cancer (NMIBC)are recurrence, progression of muscle invasive bladder cancer (MIBC), and metastasis. Biological markers such as fibroblast growth factor receptor-3 (FGFR3) and hypoxia-inducible factor-1α (HIF-1α) are related to muscle invasiveness of bladder cancer. This study was aimed to analyze the expression of FGFR3 and HIF-1α to predict muscle invasiveness in bladder cancer patients.METHODS This was an observational study with a case-control design. Sixty patients with bladder cancer, who underwent histopathology examinations at the Department of Pathology, Faculty of Medicine, Universitas Sumatera Utara/H. Adam Malik Hospital from January 2012 to December 2015, were included in this study. Samples were then classified into 30 NMIBC and 30 MIBC groups. All samples were analyzed with an immunohistochemistry assay for FGFR3 and HIF-1α. H-scores were used to determine the relationships between each group.RESULTS FGFR3 was expressed in 29 (96.7%) patients of the NMIBC group, and 23 (76.7%) patients of the MIBC group (p=0.026, OR=8.8; 95% CI=1.01–76.96). HIF-1α was expressed in only 1 (3.33%) patient of the NMIBC group, and 15 (50%) patients of the MIBC group (p<0.001, OR=29; 95% CI=3.49–241.13).CONCLUSIONS There was a difference in upregulation of FGFR3 and HIF-1α expression in both the NMIBC and MIBC groups.
The susceptibility of pathogens associated with acne vulgaris to antibiotics
Authors: Sitohang Irma Bernadette Simbolon , Fathan Hafizah , Effendi Evita , Wahid Mardiastuti 
Published: May 2019

BACKGROUND Acne vulgaris is a pilosebaceous disorder. Bacterial activity and inflammation both influence acne formation. Antibiotics suppress the bacterial activities and elicit anti-inflammatory effects. The overuse of antibiotics may lead to resistance in bacteria. This study was aimed to provide an overview of bacteria that may cause acne and determine their susceptibility to antibiotics.METHODS This was a cross-sectional study sampling from 93 patients with acne in Ciptomangunkusumo Hospital. Comedones were extracted and cultured on Brucella blood agar, under aerobic and anaerobic conditions at 35oC for 24–48 hours. Bacterial identification was performed using Vitek®, and susceptibility test using E-test. Data interpretation was based on the Clinical and Laboratory Standards Institute 2015.RESULTS Staphylococcus epidermidis (50.5%), Propionibacterium acnes (11.0%), and Staphylococcus aureus (7.7%) were identified. Bacteria were not found in 69.2% and 1.1% of samples in anaerobic and aerobic cultures, respectively. P. acnes was susceptible to doxycycline (100%) and minocycline (100%), while 10% was resistant to erythromycin, clindamycin, and tetracycline. S. epidermidis was susceptible to minocycline (100%); but resistant to erythromycin (65.2%), clindamycin (52.2%) and tetracycline (32.6%). The susceptibility of S. epidermidis to doxycycline was 89.1%, which was lower than that of P. acnes (100%). S. aureus was found to be sensitive to minocycline (100%), doxycycline (71.4%), clindamycin (71.4%), and tetracycline (71.4%); but it was resistant to erythromycin (42.9%).CONCLUSIONS Doxycycline and minocycline showed 100% effectiveness for P. acnes. The isolated bacteria were more susceptible to doxycycline compared to tetracycline. The use of clindamycin and erythromycin needs to be limited as most S. epidermidis isolates were resistant to both.
DiabCare Asia 2012: diabetes management, control, and complications in patients with type 2 diabetes in Indonesia
Authors: Cholil Achmad Rudijanto , Lindarto Dharma , Pemayun Tjokorda Gde Dalem , Wisnu Wismandari , Kumala Poppy , Puteri Happy Helene Sulung 
Published: May 2019

BACKGROUND Indonesia was a part of the most recent edition of DiabCare Asia held in 2008. DiabCare Asia 2012 is modeled after a similar project to provide the latest information to facilitate healthcare policymaking in this area.METHODS This was an observational, non-interventional, cross-sectional study of patients with type 2 diabetes mellitus from primary, secondary, and tertiary care centers in Indonesia. Patient data collected included demography, medical history complications, eye and foot examinations, diabetes management, and most recent laboratory investigations. Blood samples were collected from all patients for the analysis of glycated hemoglobin (HbA1c).RESULTS A total of 1,967 patients participated in the study, with a mean (SD) age of 58.4 (9.5) years and a median (range) duration of diabetes 6.0 (0.1−47.0) years. The percentage of patients with HbA1c <7.0% was 30.8% and the mean (SD) HbA1c level was 8.3 (2.2%). The proportion of patients using insulin was 34.7% with a mean (SD) total daily dose of 37.9 (24.1) IU. The most common diabetes-related complications were peripheral neuropathy (59.1%), erectile dysfunction (32.4%), and eye complications (29.1%).CONCLUSIONS Glycemic and metabolic control remain unsatisfactory in type 2 diabetes patients in Indonesia. Efforts are needed to optimize control and prevent complications in these patients.
A IMAGEM DA FESTA NACIONAL DO DOCE – FENADOCE EM PELOTAS (RS), BRASIL, PERANTE A PERCEPÇÃO DOS RESIDENTES
Authors: Berselli Cristiane , Durieux Zucco Fabrícia 
Published: May 2019

Eventos especiais como festivais são atividades que revitalizam as tradições locais, aumentam a qualidade de vida e a imagem da comunidade (Gursoy, Kim & Uysal, 2004). Destaca-se que a imagem é uma dimensão importante a ser analisada na percepção dos residentes diante de um festival. Este estudo é exploratório, descritivo e quantitativo e teve por objetivo analisar a percepção dos residentes sobre a imagem da Fenadoce, antes da realização do evento. Os resultados descritivos através de média aritmética são apresentados (n=111). Os resultados descritivos são apresentados através da média aritmética. Como principal resultado, a percepção dos residentes, de maneira geral, foi positiva perante a imagem da Fenadoce. Receberam pontuações positivas os elementos relacionados a benefícios a comunidade, custos percebidos, qualidade de serviços e infraestrutura. Somente o estacionamento é fator crítico que merece atenção dos gestores. Identificou-se que os residentes frequentam o evento em família e casais. As conclusões apresentam, também, apontamentos acadêmicos e gerenciais sobre estes resultados.
A Randomized, Multicenter, Prospective, Crossover, Open-Label Study of Factors Associated With Patient Preferences for Naloxegol or PEG 3350 for Opioid-Induced Constipation
Authors: Brenner Darren M. , Hu Yiqun , Datto Catherine , Creanga Dana , Camilleri Michael 
Published: May 2019

Objectives:
To determine patient preference for treating opioid-induced constipation (OIC) using naloxegol or polyethylene glycol (PEG) 3350 in patients receiving opioids for noncancer pain.

Methods:
This crossover study included two 2-week active treatment periods, each preceded by a 1-week washout period (NCT03060512). Individuals with baseline Bowel Function Index scores ≥30 were randomized to 1 of 2 treatment sequences (naloxegol/PEG 3350 or PEG 3350/naloxegol). Patient preference (primary end point) was measured at the end of the second treatment period.

Results:
Of 276 patients randomized, 246 completed both treatment periods and reported preference (per protocol). Similar proportions of patients reported overall preference for naloxegol (50.4%) or PEG 3350 (48.0%; P = 0.92); 1.6% reported no preference. Medication characteristics influencing preference were similar for both treatments, except convenience and working quickly, which were strong influences of preference for higher proportions of patients preferring naloxegol (69.9% and 39.0%, respectively) vs those preferring PEG 3350 (29.9% and 27.4%, respectively). Patients aged <50 years or receiving laxatives within the previous 2 weeks generally preferred naloxegol. Changes from baseline in overall Bowel Function Index and Patient Global Impression of Change scores were similar between treatments, but analyses according to treatment preference revealed clinical improvement aligned with reported preference. Safety profiles were generally consistent with known medication profiles.

Conclusions:
Almost equal proportions of patients with OIC reported similar preference for daily naloxegol or PEG 3350 treatment, and their preference was generally supported by clinically relevant and measurable improvements in OIC symptoms.
Crianças e literatura: múltiplos encantos / Children and literature: multiple enchantments
Authors: Ventura Fabiana Cristina , Chaluh Laura Noemi 
Published: May 2019

A leitura literária é essencial para e na formação humana, ao ler o indivíduo interage não apenas com a palavra escrita, mas com outras experiências, portanto, ler conduz ao encontro com os outros e consigo mesmo. O presente trabalho versa sobre uma pesquisa qualitativa, do tipo etnográfico, desenvolvida em uma escola pública da Rede Municipal de Ensino da cidade de Rio Claro/SP. A mesma teve como objetivo analisar as formas de abordagem da literatura infantil e juvenil em uma sala de aula. Neste artigo compartilhamos nossa experiência ao acompanhar o trabalho de uma professora do 5º ano que realizava com a turma, diariamente, um momento de leitura literária. As observações dessa prática possibilitaram perceber o compromisso da educadora com a formação de leitores e o modo como a literatura passou a fazer parte das práticas cotidianas das crianças. A análise dessas observações está sustentada no paradigma indiciário (GINZBURG, 1989).
PALAVRAS-CHAVE: Práticas de Leitura. Literatura Infantil e Juvenil. Formação de Leitores.
A contribuição dos sinalários para a divulgação científica em Libras / The contribution of the signalers to scientific dissemination on Sign Language
Authors: Malacarne Vilma , Oliveira Verônica Rosemary de 
Published: May 2019

Este artigo visa analisar a produção de sinalários - glossários em Língua Brasileira de Sinais (Libras) - referentes Ã área das ciências, os quais podem ser encontrados na plataforma digital de compartilhamento Youtube. Busca-se apresentar a importância desses recursos para ampliação da divulgação científica em âmbito educacional e social, bem como compreender como ocorre a educação de alunos surdos e, também, como os sinalários contribuem para que a área das ciências se torne acessível a este público. A pesquisa tem caráter bibliográfico e documental pois faz referências a autores que pesquisam sobre a educação dos surdos e divulgação científica, além de análise de vídeos com sinalários em Libras disponibilizados na plataforma digital de compartilhamento Youtube. Com a pesquisa percebemos que não há uma padronização nos sinais pois há uma tendência destes serem organizados por instituições locais ou regionais respeitando apenas a variação linguística regional, dificultando a compreensão pelo público mais amplo.
PALAVRAS-CHAVE: Sinalários, Libras, divulgação científica, educação de surdos.
Máquinas de Rube Goldberg: aportes para o ensino de Ciências e Matemática /Rube Goldberg machines: Contributions to STEM education
Authors: Caldeira Pedro Zany , Bossler Ana Paula 
Published: May 2019

Estudantes de duas licenciaturas (Ciências da Natureza e Matemática) foram incentivados pelos docentes de uma disciplina de Mídia e Educação a conceber, montar e analisar máquinas de Rube Goldberg, de modo a verificar-se como estas podem ser usadas em contextos de ensino. Nas máquinas analisadas os estudantes conseguiram identificar 90% dos fenômenos da Física e 25% dos fenômenos da Química presentes e nenhum dos princípios matemáticos incluídos na sua estrutura. No entanto, do conjunto dos fenômenos científicos incluídos no funcionamento das máquinas, eles só conseguiram nomear parcialmente um. Estes resultados levaram os professores a pedirem aos estudantes para apresentarem as suas máquinas usando a terminologia e o vocabulário científico corretos. Nessa apresentação os estudantes apenas erraram a nomeação de dois fenômenos científicos, ficando explícito o impacto da pedagogização do exercício e do discurso dos professores (explicação usando terminologia e vocabulário científico e matemático correto) sobre as aprendizagens dos alunos.
PALAVRAS-CHAVE: Teoria da Variação da Aprendizagem. Máquina de Rube Goldberg. Objeto de aprendizagem. Responsailidade instrutiva. Resposabilidade discursiva
Concepções de alunos de graduação sobre a relação entre arte e física / Conceptions of physics students about the relationship art and physics
Authors: Vilhalva Gabriel Alexsandro de Freitas , Ferreira Fernando Cesar 
Published: May 2019

Considerando o reconhecido papel da arte ao longo da história como elemento de influência na produção de conhecimento científico, este estudo exploratório buscou levantar concepções que os alunos das Licenciaturas em Física - presencial e a distância - da Universidade Federal da Grande Dourados (UFGD) possuem sobre a relação entre arte e Física. O recorte para a Física situa-se na mecânica. Para o levantamento de concepções que estudantes têm sobre a relação entre Física e arte foi aplicado um questionário online com questões abertas e fechadas sobre arte e Física, enfocando percepção do respondente, aspectos da relação histórica entre ambas e reflexos na construção de conhecimento científico. A análise das respostas mostrou evidências de aceitação da arte como elemento capaz de contribuir para o ensino de Física.
PALAVRAS-CHAVE: arte, mecânica, ensino de física.
Parque ecológico Bosque dos Papagaios: uma proposta para um ensino de ciências em espaço não formal / Bosque dos Papagaios Ecological Park: a proposal to teach science in an informal environment
Authors: Sousa Maria do Socorro Magalhães de , Reis Terezinha Ribeiro , Rizzatti Ivanise Maria 
Published: May 2019

A cidade de Boa Vista/RR apresenta verdadeiros laboratórios de iniciação científica em campo aberto, ainda pouco considerado como espaço educativo pelos professores, seja no ensino fundamental ou médio. Neste sentido, este trabalho teve como objetivo apresentar a um grupo de mestrandos, da disciplina de Espaços não formais do Programa de Pós-Graduação em Ensino de Ciências da Universidade Estadual de Roraima, as potencialidades do Parque Ecológico Bosque dos Papagaios, enquanto espaço não formal educativo. O trabalho foi desenvolvido com dez mestrandos que participaram de uma prática de ensino intitulada de aula passeio. A aula passeio, avaliada sob a perspectiva da Pedagogia de Freinet, possibilitou aos mestrandos uma nova compreensão do dinamismo da função educacional, ou seja, motivou interesses ligados a vivências pessoais que na maioria das vezes não são considerados no ambiente escolar. Por meio da visita os mestrandos revelaram emoções, sensações e aguçamento da memória, que despertaram possibilidades na interação entre espaço formal e não formal de ensino, tendo em vista a abrangência dos recursos disponíveis no local visitado e eixos temáticos ligados à fauna, flora, estudo do solo, recursos hídricos, entre outros, pertinentes ao ensino de ciências e outras áreas do conhecimento praticado no espaço formal de ensino.
Palavras-chave: Mestrado em Ensino de Ciências. Aula Passeio. Ensino de Ciências.
The determinants of local public spending on culture
Authors: Kopańska Agnieszka 
Published: May 2019

AbstractMunicipalities in Poland are important makers of local cultural life. Municipalities organise and fund public cultural entities: libraries, houses of culture and so on. They decide on 70% of public spending on culture. The local spending on culture was grown in the past years. But the level of this spending varies between municipalities. The aim of this study is to find determinants of these differences. Public spending on culture is important in less-developed or peripheral regions where citizens do not have access to private cultural institutions. That is why this study focuses on rural municipalities. In econometric panel model, 1,565 units and their operational spending on culture in the years 2002–2014 is analysed. Four groups of potential determinants of spending are analysed: characteristics of local society, the financial condition of local government, characteristics of local politicians and the factors that influence the costs of cultural services. Such an approach has roots in the median voter model and is widely used in the analysis of decentralised spending, but the studies related to cultural spending are rare. To my knowledge, there is no such analysis for Poland or other East European countries. This study proved that an expenditure demand model is good for the analysis of local spending. This kind of analysis can help to understand local spending’s variation. It also helps to design the proper revenues equalisation system.
The Use of the Twitter in Public Benefit Organisations in Poland: How Communicative Function of Tweets Translates Into Audience Reaction?
Authors: Oliński Marian , Szamrowski Piotr 
Published: May 2019

AbstractScientific research into the use of social media in the activities of nonprofit organisations has focused mainly on the scale of their application and on the analysis of the static elements of the social media profile. The research presented in this article concerns the specific form of nonprofit organisation, namely public benefit organisations (PBOs). The aim of the article is, therefore, to identify the leading function of the content published on Twitter and to determine how this function translates into public engagement. During the research process, the content analysis method was used (a sample of 981 tweets was selected for this purpose). The results indicate that Twitter usage by Polish PBOs is of minor importance. Generally, with the exception of the largest organisations, the Twitter profile was primarily focused on delivering information only and, hence, was used in one-way communication.
BER of Underwater Wireless Optical Communication Systems with SIMO Detection over Strong Oceanic Turbulence
Authors: Fu Yuqing 
Published: May 2019

Abstract
A spherical wave propagates through the strong underwater turbulence media is modeled as gamma–gamma random variable in the underwater wireless optical communication (UWOC) systems. To mitigate turbulence-induced fading, spatial diversity over UWOC links is proposed. Furthermore, the exact bit error rate (BER) expressions for both single-input single-output (SISO) and single-input multiple-output (SIMO) UWOC systems with optimal combining based on on–off keying (OOK) modulation are analytically derived. Then the system performance is simulated with various variations of the underwater turbulence, i.e. the rate of dissipation of kinetic energy per unit mass of fluid, the ratio of temperature to salinity contributions to the refractive index spectrum, and the UWOC system link length. The results show that the analytical expressions for describing the system performance are valid and spatial diversity can considerably improve the system performance.
Crystal structure of bis{μ2-bis{(((((1-methoxyimino)ethyl)phenyl)imino)methyl)-2-phenolato-κ3
N,O:O}copper(II)}, C68H68Cu2N8O8
Authors: Huang Jing , Ma Jin-Xia , Wei Ping , Zhao Ji-Xing 
Published: May 2019

Abstract
C68H68Cu2N8O8, monoclinic, P21/c, a = 16.241(3) Å, b = 12.1604(19) Å, c = 15.531(3) Å, β = 96.364(3)°, Z = 2, V = 3048.3(9) Å3, R
gt(F) = 0.0497, wR
ref(F
2) = 0.1263, T = 296(2)K.
Crystal structure of 2-(4-ammoniocyclohexyl)-3-(pyridin-2-yl)imidazo[1,5-a]pyridin-2-ium 2-[(2-carboxylatophenyl)disulfanyl]benzoate dihydrate, [C18H22N4][C14H8O4S2] ⋅ 2H2O
Authors: Tan Sang Loon , Tiekink Edward R.T. 
Published: May 2019

Abstract
[C18H22N4][C14H8O4S2]⋅2H2O, orthorhombic, P212121 (no. 19), a = 9.7616(1) Å, b = 16.7411(2) Å, c = 18.6843(2) Å, V = 3053.39(6) Å3, Z = 4, R
gt(F) = 0.0265, wR
ref(F
2) = 0.0679, T = 100(2) K.
An Investigation on the Effect of High Temperatures on the Mechanical Properties and Microstructure of Concrete Containing Multiwalled Carbon Nanotubes
Authors: Pachideh Ghasem , Gholhaki Majid , Moshtagh Amin , Kafi Felaverjani Mohammadali 
Published: May 2019

Abstract
In this article, the effect of multiwalled carbon nanotubes on the properties of concrete was evaluated in the postheat-treated condition. For this, a number of cylindrical specimens (10 by 20 cm), including multiwalled carbon nanotubes in different percentages of 0.5, 1, and 1.5 % by weight of cement, were cast. Then, the concrete specimens were exposed to temperatures of 25°C, 100°C, 250°C, 500°C, and 700°C in an electric furnace, and after they cooled down, compressive and tensile strength tests were carried out on them. The results show that by increasing the number of multiwalled carbon nanotubes in concrete, the compressive and tensile strengths of concrete increase up to 138 and 88 %, respectively. In addition, the dissipation of energy and modulus of elasticity of the concrete specimens were up to two times greater than those of the control specimens. The scanning electron microscope test results indicated that a strong bond between concrete particles exists at room temperature and above.
Effect of Graphene on Mechanical and Flowability Properties of Low-Density Polyethylene Composites
Authors: Sabet Maziyar , Soleimani Hassan 
Published: May 2019

Abstract
The logical outline and assembly of structural–functional materials are progressive tendencies of materials knowledge. In this study, it was found that the homogenous graphene (Gr) spread in low-density polyethylene (LDPE) considerably increases the mechanical properties of LDPE/Gr composites. The high specific surface areas and superior properties of Gr improved thermal strength, conductivity, storage modulus, and mechanical properties of composites. Results display that the inclusion of Gr (0–3 wt.%) and frequency growth enhanced the viscosity, loss modulus, and storage modulus of LDPE/Gr composites significantly. The addition of Gr also augmented the Young’s modulus, Young’s strength, tensile modulus, and elongation modulus, but the tensile strength values of LDPE/Gr composites have not changed significantly. The elongation test displayed reduction values with further addition of Gr in LDPE/Gr composites. The effect of temperature rise caused the decrease in the storage modulus with Gr addition; however, further inclusion of Gr mitigated the trend of storage modulus reduction of the composites considerably. This study also presents that Gr inclusion leads to limit polymer chain mobility, which reduces maximum strain and increases the melt flow indexes during material processing.
PORTAFOLIO DE COMMODITIES MINEROS Y SU INCIDENCIA EN LAS EXPORTACIONES. PERÚ: 2008-2017
Authors: Gomero Gonzales Nicko Alberto 
Published: May 2019

Objetivo: El estudio tiene como objetivo determinar cómo los precios de los commodities mineros, ejercen influencia sobre las exportaciones y determinar el grado de correlación entre los precios y los volúmenes exportados. Método: El estudio es de tipo descriptivo y correlacional no experimental. Para realizar los contrastes respectivos se recurrió a información oficial procesada por el Ministerio de Energía y Minas de Perú. Se utilizó solo información secundaria e histórica. Resultados. Se llegó a determinar que los precios del portafolio de productos, debido a los vaivenes del mercado global se mueven en la misma dirección, aunque no con una simetría perfecta, pero no se encontró la misma evidencia con los volúmenes exportables , que por un lado presentan una correlaciones débiles y en algunos casos negativas , pero al contrastar los precios con el valor de las exportaciones se encontró una fuerte correlación para el oro , el zinc , el cobre , pero no así para la plata , cuya correlación con el precio es bastante débil . Conclusiones: Los precios de los commodities tienen el mismo recorrido por los cambios en el mercado, generando efectos dispersos en las exportaciones de estos productos.