bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of complete replacement of fish oil with plant oil mixtures and algal meal on growth performance and fatty acid composition in juvenile yellowtail Seriola quinqueradiata
Authors: Fukada Haruhisa , Kitagima Renato , Shinagawa Junpei , Morino Haruka , Masumoto Toshiro 
Published: October 2019

AbstractDocosahexaenoic acid (DHA) is an essential fatty acid for marine carnivorous fish. Algal meal (AM), available as a new dietary DHA source, could completely replace dietary fish oil (FO). In this study, dietary FO was replaced with plant oil mixtures and AM in juvenile yellowtail Seriola quinqueradiata to investigate its effects on growth performance and fatty acid composition. The FO control diet was prepared with only pollack liver oil as the lipid source. For the non-FO diets, pollack liver oil was completely replaced with mixtures of canola oil and palm oil, with AM supplementation at 0% (AM0), 1% (AM1), 2% (AM2), 3% (AM3), and 4% (AM4). After completion of the 8-week feeding trial, the AM2 group showed significantly higher values for final body weight and feed efficiency than the AM0 group. No significant differences were observed in the other parameters of growth performance. Whole-body fatty acid composition reflected the dietary fatty acid composition in all dietary groups. These findings demonstrate that AM is useful as a DHA source in yellowtail aquaculture, thus contributing to a reduction in the use of FO in fish diets.
Modified approach for identifying weak zones for effective sand management
Authors: Sulaimon Aliyu Adebayo , Teng Lim Lee 
Published: October 2019

AbstractSand production is a major problem that the oil and gas industry has been facing for years. It can lead to loss of production, equipment damage or complete well abandonment. Prediction of sand has been historically challenging due to the periodic nature of sand production, insufficient laboratory tests and lack of field tests validation. Analyses have been performed to identify weak zones for planned wells, and common technique is the application of shear modulus and mechanical properties log (MPL) criteria developed by Tixier et al. (J Pet Technol 27:283–293, 1975). However, the set criteria have been found to be generally inadequate to detect transition zone or predict weak formation in some fields. In this study, using the knowledge of rock behavior, geomechanical properties and well log data, we have established new simple criteria for identifying fragile sections within a transition zone. In situ logging data from a field X, located in Sabah, Malaysia, and Field Y, located in Shimokita, Japan, were used in this study. Using the threshold for shear modulus and MPL, the criteria for the geomechanical properties are set to differentiate formation strengths at different depths. The threshold for Poisson’s ratio is 0.34, Young’s modulus at 1.6 × 106 psi and the unconfined compressive strength at 2400 psi. The MPL and geomechanical models were generated to predict sanding incident. The results were subsequently validated with artificial neural network using MATLAB. Also, critical wellbore pressure is calculated and acts as a guide to operate outside the sand failure envelope. Thus, the prediction of the weak formation using geomechanical properties has been further established in this study.
Psychological resilience moderates influence of depression on sleep dysfunction of people living with diabetes
Authors: Wojujutari Ajele Kenni , Alabi Oladejo Teslim , Emmanuel Idehen Egbeware 
Published: October 2019

AbstractObjectivesThe study examined the influence of depression on sleep dysfunction in people living with diabetes mellitus and investigated the moderating role of psychological resilience on the influence of depression on sleep dysfunction of patients.MethodsA cross-sectional survey was carried out among 380 (age 25–77 years; mean = 38.6; SD = 6.07) people living with diabetes who are registered patients and were attending the clinic in Department of Endocrinology, Ondo State Specialist Hospital, Akure.ResultsResults showed that depression significantly influence sleep dysfunction of people living with diabetes, β = 0.3991, 95% CI (0.5393, 0.2588), t = 21.5010,p < 0.005. Results also showed significant moderating role of psychological resilience on the influence depression on sleep dysfunction of people living with diabetes, β = 0.7805, 95% CI (0.7091, 0.8519), t = 21.5010, p < 0.005.ConclusionsSleep dysfunction of individuals living with diabetes as result of their level of depression could be moderated by patient’s level of psychological resilience. Along these lines, the study concludes that experts should focus more on diabetes patient’s psychological resilience adequacy in their management, guidance and modification programs.
The cross‐sectional association of cognitive stimulation factors and cognitive function among Latino adults in Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Authors: Vásquez Priscilla M. , Tarraf Wassim , Doza Adit , Marquine Maria J. , Perreira Krista M. , Schneiderman Neil , Zeng Donglin , Cai Jianwen , Isasi Carmen R. , Daviglus Martha L. , González Hector M. 
Published: October 2019

AbstractIntroductionHigher cognitive stimulation (CS) is associated with improved cognition. Sources of CS among Hispanics/Latinos are understudied.MethodsIn the Hispanic Community Health Study/Study of Latinos 2008 to 2011 (n = 9438), we used finite mixture models to generate latent CS profiles, and multivariate linear regressions to examine associations with cognition in Hispanic/Latino adults (45–74 years). CS included education, occupation, social network, and acculturation. Cognitive measures included the Six‐Item Screener, Brief‐Spanish English Verbal Learning Test Sum and Recall, Controlled Oral Word Association Test, Digit Symbol Substitution, and Global Cognition.ResultsTwo CS profiles emerged, and were labeled “typical” and “enhanced.” The enhanced CS profile (22%) had more family connections, bicultural engagements, skilled/professional occupations, education, and higher cognitive scores.DiscussionAn enhanced CS profile emerged from contextual and culturally relevant factors, and was associated with higher cognitive scores across all measures. This provides initial evidence on how factors coalesce to shape cognitive protection in Hispanics/Latinos.
dl-Methionine supplementation in a low-fishmeal diet affects the TOR/S6K pathway by stimulating ASCT2 amino acid transporter and insulin-like growth factor-I in the dorsal muscle of juvenile cobia (Rachycentron canadum)
Authors: He Yuanfa , Chi Shuyan , Tan Beiping , Dong Xiaohui , Yang Qihui , Liu Hongyu , Zhang Shuang , Han Fenglu , Liu Di 
Published: October 2019

AbstractAn 8-week feeding experiment was conducted to investigate the effects ofdl-methionine (Met) supplementation in a low-fishmeal diet on growth, key gene expressions of amino acid transporters and target of rapamycin (TOR) pathway in juvenile cobia,Rachycentron canadum. Seven isonitrogenous and isolipidic diets were formulated, containing 0·72, 0·90, 1·00, 1·24, 1·41, 1·63 and 1·86 % Met. Weight gain and specific growth rates increased gradually with Met levels of up to 1·24 % and then decreased gradually. In dorsal muscle, mRNA levels of ASCT2 in the 1·00 % Met group were significantly up-regulated compared with 0·72, 1·63, and 1·86 %. The insulin-like growth factor-I (IGF-I) mRNA levels in the dorsal muscle of fish fed 1·00 and 1·24 % Met were higher than those in fish fed other Met levels. In addition, fish fed 1·24 % Met showed the highest mRNA levels of TOR and phosphorylation of TOR on Ser2448. The phosphorylation of ribosomal p70-S6 kinase (S6K) on Ser371in the dorsal muscle of fish fed 1·86 % Met was higher than those in the 0·72 % group. In conclusion, straight broken-line analysis of weight gain rate against dietary Met level indicates that the optimal Met requirement for juvenile cobia is 1·24 % (of DM, or 2·71 % dietary protein). Met supplementation in a low-fishmeal diet increased cobia growth via a mechanism that can partly be attributed to Met’s ability to affect the TOR/S6K signalling pathway by enhancing ASCT2 and IGF-I transcription in cobia dorsal muscle.
Maxent modelling for predicting climate change effects on the potential planting area of tuber mustard in China
Authors: Li H. Q. , Liu X. H. , Wang J. H. , Xing L.G. , Fu Y. Y. 
Published: October 2019

AbstractPotential planting area for tuber mustard was simulated using the Maxent model under current and future conditions based on 591 coordinates and 22 environmental layers. Model accuracy was excellent, with area under the receiving operator curve values of 0.967 and 0.958 for model training and testing, respectively. Dominant factors were mean diurnal range, mean temperature of the coldest quarter, annual mean temperature and minimum temperature of the coldest month, with thresholds of 6.5–7.5, 5.5–9, 16–19 and 2.0–6.5 °C, respectively. Under current conditions, suitable habitat areas (2.16% of total land in China) were concentrated mainly in Central, Southwest and East China, which can be defined as three occurrence and diffusion centres. In the 2050s and 2070s, suitable habitat areas are predicted to change to 3.72 and 3.92%, and 3.60 and 3.73% under scenarios RCP4.5 and RCP6.0, respectively, indicating that suitable habitat areas will increase slightly. However, future distribution of tuber mustard was predicted to differ among provinces or cities, i.e. predicted suitable habitat areas in Sichuan Province increased up to the 2050s but remained relatively unchanged between the 2050s and 2070s; in Chongqing city they first increased and then decreased; in Hunan, Anhui, Jiangsu, Zhejiang and Fujian Provinces they increased continuously; and in Guizhou, Hubei, Jiangxi Provinces and Shanghai city they first decreased, and then increased. The results from the current study provide useful information for management decisions of tuber mustard.
Low abundance of the Endangered timneh parrot Psittacus timneh in one of its presumed strongholds
Authors: Valle Simon , Collar Nigel J. , Barca Benjamin , Dauda Patrick , Marsden Stuart J. 
Published: October 2019

AbstractAlthough both the grey parrot Psittacus erithacus and the recently recognized timneh parrot Psittacus timneh are categorized as Endangered because of harvest for the pet trade and loss of habitat, the latter has a much smaller range and may be largely restricted to a few stronghold areas. In March–April 2018 we surveyed for a total of 114 hours in and around one of these presumed strongholds, the large and well-protected Gola Rainforest National Park, the Sierra Leonean portion of the Gola Transboundary Peace Park. Timneh parrots were encountered at a rate of 0.1 groups/h in the National Park and 0.3 in the buffer zone, indicating densities of 1–3 individuals per km2. These figures are similar to recent density estimates from the Liberian side of the Peace Park, suggesting that the transboundary population amounts to c. 2,400 individuals inside the Park and an unknown number in the surrounding areas. Densities of the timneh parrot may be generally low even in strongholds, its numbers may be declining steeply, and the global population size is probably lower than previously believed.
Profiles of Normal Cognition in Essential Tremor
Authors: Cersonsky Tess E. K. , Kellner Sarah , Chapman Silvia , Huey Edward D. , Louis Elan D. , Cosentino Stephanie 
Published: October 2019

AbstractObjectives:Patients with essential tremor exhibit heterogeneous cognitive functioning. Although the majority of patients fall under the broad classification of cognitively “normal,” essential tremor is associated with increased risk for mild cognitive impairment and dementia. It is possible that patterns of cognitive performance within the wide range of normal functioning have predictive utility for mild cognitive impairment or dementia. These cross-sectional analyses sought to determine whether cognitive patterns, or “clusters,” could be identified among individuals with essential tremor diagnosed as cognitively normal. We also determined whether such clusters, if identified, were associated with demographic or clinical characteristics of patients.Methods:Elderly subjects with essential tremor (age >55 years) underwent comprehensive neuropsychological testing. Domain means (memory, executive function, attention, visuospatial abilities, and language) from 148 individuals diagnosed as cognitively normal were partitioned usingk-means cluster analysis. Individuals in each cluster were compared according to cognitive functioning (domain means and test scores), demographic factors, and clinical variables.Results:There were three clusters. Cluster 1 (n= 64) was characterized by comparatively low memory scores (p< .001), Cluster 2 (n= 39) had relatively low attention and visuospatial scores (p< .001), and Cluster 3 (n= 45) exhibited consistently high performance across all domains. Cluster 1 had lower Montreal Cognitive Assessment scores and reported more prescription medication use and lower balance confidence.Conclusions:Three patterns of cognitive functioning within the normal range were evident and tracked with certain clinical features. Future work will examine the extent to which such patterns predict conversion to mild cognitive impairment and/or dementia.
Doing Politics Differently? Applying a Feminist Institutionalist Lens to the U.K. Women's Equality Party
Authors: Evans Elizabeth , Kenny Meryl 
Published: October 2019

AbstractThe U.K. Women's Equality Party (WEP) was established in 2015 to “bring about change by winning—support, votes and seats.” It has thus far recruited tens of thousands of members and run candidates in European, national, devolved, and local elections. This article provides one of the first empirical analyses of this new actor in U.K. politics. Adopting a feminist institutionalist lens, we examine the extent to which WEP “does things differently” by looking at its discourse, formal party rules, and informal ways of doing things “on the ground.” Drawing on a set of semistructured interviews, observations of local and national party meetings, and document analysis, we argue that while WEP has to some extent tried to set up alternative participatory structures and new “ways of working,” it has also at times fallen back on more traditional, centralized, and hierarchical modes of party organizing, as well as informal practices that are more typically associated with male-dominated parties.
Exposure to placental insufficiency alters postnatal growth trajectory in extremely low birth weight infants
Authors: Chou Fu-Sheng , Yeh Hung-Wen , Chen Chu-Yen , Lee Gene T. , Parrish Marc R. , Omede Mmeyeneabasi , Pandey Vishal 
Published: October 2019

AbstractGrowth in the immediate postnatal period for extremely low birth weight (ELBW, birth weight < 1000 g) infants is an important topic in neonatal medicine. The goal is to ensure adequate postnatal growth and to minimize complications resulting from suboptimal growth. Past efforts have focused on postnatal nutrition as well as on minimizing comorbidities. It has not been systematically assessed whether antenatal factors play a role in postnatal growth. In this report, we conducted a retrospective study on 91 maternal–neonatal pairs. We prospectively collected maternal and neonatal demographic data, neonatal nutrition in the first 7 days of life and after enteral nutrition is fully established, comorbidity data, as well as weight data from birth to 50 weeks corrected gestational age. We developed a linear mixed-effects model to examine the role of placental insufficiency, as defined by fetal Doppler studies, in postnatal weightz-score trajectory over time in the ELBW population. We relied on Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC) for model selection. Interestingly, the selected model included a quadratic term of time and a placental insufficiency-by-time interaction term. In a covariate analysis, AIC and BIC both favored a model that included calories intake in the first 7 days of life and the total duration of antibiotics as fixed-effects, but not their interaction terms with time. Overall, we demonstrated for the first time that placental insufficiency, an antenatal factor, is a major determinant of postnatal weight trajectory in the ELBW population. Prospective studies are warranted to confirm our findings.
The National Project on Achievement in Twins
Authors: Hart Sara A. , Martinez Kim , Kennedy Patrick C. , Ganley Colleen M. , Taylor Jeanette 
Published: October 2019

AbstractThe National Project on Achievement in Twins (NatPAT) began in 2017 as part of the third funding cycle of the Florida Learning Disabilities Research Center, a program project grant funded by the Eunice Kennedy Shriver National Institute of Child Health and Development. NatPAT will have a nationally representative sample of elementary school-aged twins in the United States. The overall goal of the project is to uncover salient factors, including genetic and environmental influences, which contribute to the co-development of reading and math performance during the critical developmental period of elementary school. Here we present the specific aims, methods and materials, and future directions of the project.
Ratio of diastolic to systolic blood pressure represents renal resistive index
Authors: Akaishi Tetsuya , Abe Michiaki , Miki Takashi , Miki Mika , Funamizu Yasuharu , Ito Sadayoshi , Abe Takaaki , Ishii Tadashi 
Published: October 2019

Abstract
Increased intrarenal vascular resistance is suggested to accompany chronic kidney diseases (CKD), which is known to be closely associated with hypertension. However, there are few studies that have examined the relationship between blood pressure and intrarenal vascular resistance. Renal color Doppler ultrasonography is one method that can non-invasively evaluate intrarenal vascular resistance. In this study, we comprehensively studied the correlations between ultrasonic parameters and blood pressure indices to elucidate their relationships. In total, 162 patients with suspected CKD were enrolled for this study. Demographics, blood pressure, blood test, urine test, and renal color Doppler ultrasonography data were obtained. The ratio of diastolic to systolic blood pressure (D/S ratio) and pulse pressure were calculated. Our results indicated strong negative correlations between the renal resistive index (RI) values in all four of the studied kidney regions and the D/S ratio. The RI values also showed significant correlations with diastolic pressure and pulse pressure, but they were weaker. Partial correlation coefficients between pulse pressure, mean arterial pressure, D/S ratio, and RI showed that D/S ratio significantly correlated with RI, but pulse pressure or mean arterial pressure did not. Systolic blood pressure did not correlate with any of the studied ultrasonic values. The negative correlation between RI values and the D/S ratio was still observed in subjects without renal dysfunction or any medications. In conclusion, D/S ratio, rather than pulse pressure or mean arterial pressure, would be the most appropriate index to estimate/calculate/judge intrarenal vascular resistance.
Serum cystatin C is increased in acute spinal cord injury: a multicentre retrospective study
Authors: Zhang JinYuan , Ding RuoTing , Xian QingZhang , Wang ZhiKun , Liu ZhongYuan , Yang JinCheng , Chen JianTing 
Published: October 2019

Abstract

Study design
A multicentre retrospective study.

Objective
A multicentre retrospective study was performed to observe the changes in serum cystatin C (CysC) levels in patients with acute spinal cord injury (SCI).

Setting
Four hospitals in China.

Methods
Over a 5-year study period, the CysC, creatinine (Cr), and blood urea nitrogen (BUN) levels of people who had incurred SCI in the preceding 7 days were collected and compared with those of people with limb fracture (LF) who were matched for injury time and gender. People with SCI also were grouped by injury duration, ASIA Impairment Scale (AIS) grade and the presence or absence of steroid therapy and compared each day.

Results
Three hundred and twenty-three samples from people with SCI were retrospectively collected; their mean serum CysC levels were significantly higher than those of people with LF (p < 0.001); No significant difference was observed in Cr or BUN levels between the two groups (p > 0.14). CysC levels increased on the second day, peaked on day 3, and returned to normal on day 5. The more severely injured individuals had higher CysC levels. Steroid therapy or not had no influence for CysC levels.

Conclusion
CysC levels are increased in patients with acute SCI, possibly as a direct result of injury. Serum CysC is a potential biomarker of SCI.
Identification of HIVEP2 as a dopaminergic transcription factor related to substance use disorders in rats and humans
Authors: Zhao Juan , Chen Chunnuan , Bell Richard L. , Qing Hong , Lin Zhicheng 
Published: October 2019

AbstractPlaying an important role in the etiology of substance use disorder (SUD), dopamine (DA) neurons are subject to various regulations but transcriptional regulations are largely understudied. For the first time, we report here that the Human Immunodeficiency Virus Type I Enhancer Binding Protein 2 (HIVEP2) is a dopaminergic transcriptional regulator. HIVEP2 is expressed in both the cytoplasm and nuclei of DA neurons. Therein, HIVEP2 can target the intronic sequence GTGGCTTTCT of SLC6A3 and thereby activate the gene. In naive rats from the bi-directional selectively bred substance-preferring P vs -nonpreferring NP rat model of substance abuse vulnerability, increased gene activity in males was associated with the vulnerability, whereas decreased gene activity in the females was associated with the same vulnerability. In clinical subjects, extensive and significant HIVEP2-SLC6A3 interactions were observed for SUD. Collectively, HIVEP2-mediated transcriptional mechanisms are implicated in dopaminergic pathophysiology of SUD.
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
Authors: Gooding Sarah , Olechnowicz Sam W. Z. , Morris Emma V. , Armitage Andrew E. , Arezes Joao , Frost Joe , Repapi Emmanouela , Edwards James R. , Ashley Neil , Waugh Craig , Gray Nicola , Martinez-Hackert Erik , Lim Pei Jin , Pasricha Sant-Rayn , Knowles Helen , Mead Adam J. , Ramasamy Karthik , Drakesmith Hal , Edwards Claire M. 
Published: October 2019

AbstractMultiple myeloma is an incurable, bone marrow-dwelling malignancy that disrupts bone homeostasis causing skeletal damage and pain. Mechanisms underlying myeloma-induced bone destruction are poorly understood and current therapies do not restore lost bone mass. Using transcriptomic profiling of isolated bone lining cell subtypes from a murine myeloma model, we find that bone morphogenetic protein (BMP) signalling is upregulated in stromal progenitor cells. BMP signalling has not previously been reported to be dysregulated in myeloma bone disease. Inhibition of BMP signalling in vivo using either a small molecule BMP receptor antagonist or a solubilized BMPR1a-FC receptor ligand trap prevents trabecular and cortical bone volume loss caused by myeloma, without increasing tumour burden. BMP inhibition directly reduces osteoclastogenesis, increases osteoblasts and bone formation, and suppresses bone marrow sclerostin levels. In summary we describe a novel role for the BMP pathway in myeloma-induced bone disease that can be therapeutically targeted.