bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the Ketoprofen Distribution in Cream-gels on the Formation of the Impurities
Authors: Lyapunov N. A. , Zinchenko I. A. , Bezuglaya E. P. , Lysokobilka A. A. 
Published: May 2019

Introduction.The fixed combination of ketoprofen, methyl salicylate and levomenthol in the form of a cream-gel is rational. Ketoprofen forms salts with bases and esters with substances containing hydroxyl groups. Ketoprofen is practically insoluble in water, and the solubility of ketoprofen salts is much higher; this can lead to its different localization in the o/w emulsion and affect the profile of ketoprofen impurities resulting from esterification.Aim.The aim of the work is to study the effect of ketoprofen distribution in cream-gels on the formation of the impurities during storage.Materials and methods.Cream-gels with pH of 5,5 or 6,8 containing ketoprofen 2,5%, levomenthol 5% and methyl salicylate 10% have been studied. For their production, ketoprofen was dissolved in the mixture oflevomenthol – methyl salicylate or in the mixed solvent ofwater – propylene glycol (PG) – diethylene glycol monoethyl ether (DGME). The impurities have been identified by liquid chromatography and the distribution of ketoprofen between the phases of the emulsion and the content of impurities in cream-gels have been determined by the same method. The rheological characteristics of cream-gels have been studied by viscosity-rotating viscometer method, and their microstructure – by optical microscopy.Results and their discussion.The formation of ketoprofen esters with PG, DGME and levomenthol in cream-gels have been studied. Differences in the localization of ketoprofen in the phases of the o/w emulsion at pH 5,5 and 6,8 have been shown. The formed impurities have been identified by the retention times of their peaks on chromatograms, by UV spectra and mass spectra. It has been established that during storage the content of ketoprofen esters with PG, DGME and levomenthol increased, but their formation rate was lower at pH=6,8 as well as at the adding of ketoprofen as a salt with trometamol into the dispersion medium of cream-gel. However, this resulted in formation of three impurities that were identified by UV spectra as decomposition products of methyl salicylate. When storing cream-gels with pH=6,8, the content of decomposition products of methyl salicylate, which were not detected at pH=5,5, increased.Conclusion.When making a cream-gel, ketoprofen is advisable to dissolve in a mixture of methyl salicylate and levomenthol and standardize the pH about 5,5. It is rational to use hydrophilic solvents without hydroxyl groups as penetration enhancers and the impurity profile could be limited to the menthol esters of the enantiomers of ketoprofen as a result.
Assessing the Impact of Technological Factors on the Stability of Liposomes the Photosensitizer Phthalocyanine Series
Authors: Timofeeva T. A. , Dmitrieva M. V. , Nikolaeva L. L. , Orlova O. L. , Oborotova N. A. , Polozkova A. P. , Krasnyuk I. I. 
Published: May 2019

Introduction.Liposomal technologies are widely used in medicine and cosmetology as a delivery system for diagnostic and medicinal products and biologically active substances. The undoubted practical importance at the stage of development of a liposomal preparation is represented by the characteristic and assessment of the sustainability of the obtained product, and special attention is paid to the study of the latter. Essentially, the methods for their preparation affect the stability of liposomes; therefore, the study of the influence of technological factors on the properties of the product at various stages of the preparation of liposomes is very important. This article is devoted to the study of the dependence of the quality of liposomes loaded with a phthalocyanine photosensitizer – thiosens, on the conditions of their production.Aim.Detection of the influence of various technological factors on the stability indicators of the liposomal form of the thiosens photosensitizer.Materials and methods.For this purpose, an analysis of the average size, polydispersity and zeta (ζ) potential of the liposomes of thiosens obtained at the stage of hydration of the lipid film, filtration of the liposomal dispersion, its extrusion, homogenization, ultrasonic treatment, and lyophilization was carried out.Results and discussion.During the preparation of a liposomal preparation, various changes in conditions can be made within the framework of the technological process. At each stage of obtaining a liposomal form, there are many critical points and parameters that must be strictly monitored and controlled. In the course of the work, the influence of technological factors on the stability of liposomal intermediate and finished products was assessed. The conditions of the most effective hydration with the formation of a stable dispersion of multilayer liposomes of thiosens and the optimal method of their grinding have been determined. It was also shown that liposomes formed after rehydration of the lyophilisate are more uniform in size and have the highest ζ-potential value in comparison with non-lyophilized liposomal dispersion.Conclusion.Using the example of a thiosens phthalocyanine photosensitizer liposomes, the influence of various technological factors on the stability of this nanostructure is shown, therefore, the characteristic and assessment of the sustainability of the resulting product according to 3 main indicators – vesicle size, polydispersity index, and ζ-potential are of undoubted practical importance.
Acrodermatitis Continua Of Hallopeau Yang Memberi Respons Baik Terhadap Terapi Kombinasi Salep Klobetasol Propionat 0,05% Dan Dapson
Authors: Megasasi Yuli , Brahmanti Herwinda , Kumala Yasmina Diah , Manggala Galih 
Published: May 2019

Acrodermatitis continua of Hallopeau (ACH) merupakan kasus jarang, yang ditandai dengan erupsi pustular steril yang mengenai ujung jari tangan dan kaki. Pengobatan ACH sulit karena kondisinya yang rekalsitran. Berbagai terapi menggunakan obat topikal atau sistemik, secara tunggal atau kombinasi telah dicoba dengan hasil yang bervariasi. Seorang anak perempuan 10 tahun dengan ACH kuku keempat dan kelima jari tangan kanan dan kuku ketiga jari tangan kiri sejak 5 tahun sebelum berobat. Pengobatan awal dengan salep klobetasol propionat 0,05% saja gagal memperbaiki lesinya. Kombinasi dengan dapson 50 mg/hari menghasilkan perbaikan lesi akral dalam waktu empat minggu, namun terdapat efek samping anemia.Steroid topikal superpoten memiliki mekanisme kerja sebagai anti-inflamasi, anti-proliferasi, imunosupresif, dan vasokonstriksi, terutama jika digunakan secara oklusif, berguna untuk menghentikan pustulasi. Dapson menghambat kemotaksis neutrofil manusia melalui sistem transduksi sinyal protein G dan mengganggu migrasi kemotaktik neutrofil melalui supresi fungsi adhesi ke epidermis yang diperantarai oleh integrin. Hal tersebut menyebabkan supresi perekrutan neutrofil serta kurangnya influks neutrofil ke dalam dermis. Kombinasi salep klobetasol propionat 0,05% yang dioklusi dan dapson dianjurkan untuk ACHÂ Kata kunci: Acrodermatitis continua of Hallopeau, klobetasol propionat, dapson
Psoriasis Pustulosa Generalisata Dan Pemfigus Foliaseus Pada Seorang Pasien Yang Diterapi Dengan Kombinasi Metotreksat Dan Azatioprin
Authors: Fadilla Yola , Febrina Dia , Haryati Nia Srie , Suwarsa Oki , Darmadji Hartati Purbo 
Published: May 2019

Psoriasis disertai penyakit bulosa autoimun yang terjadi pada satu orang sangat jarang terjadi. Diduga terdapat peranan plasminogenactivator, predisposisi genetik, atau faktor pencetus infeksi dalam patogenesis psoriasis yang disertai pemfigus foliaseus. Metotreksat dilaporkan efektif sebagai terapi psoriasis pustulosa dan azatioprin sebagai terapi penyakit bulosa autoimun menimbulkan efek samping yang lebih dapat ditoleransi.Dilaporkan seorang pasien laki-laki berusia 38 tahun dengan diagnosis psoriasis pustulosa generalisata disertai pemfigus foliaseus. Selain gambaran klinis, diagnosis psoriasis pustulosa ditegakkan dengan pemeriksaan histopatologis, sedangkan diagnosis pemfigus foliaseus ditegakkan melalui pemeriksaan histopatologis dan direct immunofluorescence (DIF). Pasien diterapi dengan kombinasi metotreksat 3x5 mg/minggu dan azatioprin 2x100 mg/hari. Setelah dua minggu mendapat terapi kombinasi, terjadi perbaikan klinis dan tidak ditemukan lesi baru. Psoriasis dan penyakit bulosa autoimun pada satu orang sulit terapinya karena penggunaan dan penghentian kortikosteroid sistemik dapat mencetuskan psoriasis pustulosa. Pada pasien ini, dipilih metotreksat sebagai terapi psoriasis pustulosa generalisata karena efektivitasnya baik dan tersedia di Indonesia. Azatioprin diberikan untuk terapi pemfigus foliaseus atas pertimbangan efek samping yang jarang terjadi dibandingkan obat imunosupresan lainnya. Dilaporkan satu pasien usia 38 tahun dengan psoriasis pustulosa generalisata disertai pemfigus foliaseus yang mendapatkan terapi kombinasi metotreksat 3x5 mg/minggu dan azatioprin 2x100 mg/hari. Perbaikan klinis didapatkan setelah dua minggu pengobatan.Â Kata kunci: azatioprin, metotreksat, pemfigus foliaseus, psoriasis pustulosa generalisata
Perbandingan Kadar Brain â€“ Derived Neurotrophic Factor Pasien Psoriasis Vulgaris Dan Bukan Pasien Psoriasis Vulgaris
Authors: Sjahrir Muhammad , Effendy Elmeida , Roesyanto Irma D 
Published: May 2019

Psoriasis adalah penyakit inflamasi kronik pada kulit, dengan dugaan kuat akibat pengaruh genetik. Psoriasis memiliki karakteristik berupa gangguan pertumbuhan dan diferensiasi epidermis serta keterlibatan agen biokimiawi, imunologik, kelainan vaskular, dan sistem saraf. Keterlibatan sistem saraf pada psoriasis salah satunya diperankan oleh brain-derived neurotrophic factor (BDNF). BDNF telah dikenal luas berperan pada kondisi stres dan depresi, namun BDNF ternyata juga memilki peran menjaga homeostasis korneosit. Penelitian ini bertujuan untuk mengetahui perbedaan kadar BDNF dalam serum pasien psoriasis vulgaris dibandingkan dengan bukan pasien psoriasis vulgaris.Penelitian ini adalah penelitian analitik dengan desain potong lintang. Sebanyak 20 orang pasien psoriasis vulgaris (kasus) dan 20 orang bukan pasien psoriasis vulgaris (kontrol) ikut serta dalam penelitian ini. Pada seluruh subyek penelitian dilakukan pengambilan darah untuk dilakukan pemeriksaan kadar BDNF dalam serum dengan metode enzyme-linked immunosorbent assay (ELISA). Kadar BDNF serum yang diperoleh kemudian dinilai perbedaannya antara kelompok kasus dan kontrol dengan menggunakan uji-t independen.Hasil penelitian didapatkan kadar BDNF dalam serum pasien psoriasis vulgaris lebih rendah secara bermakna (852,99 Â± 172,28 pg/ml) dibandingkan dengan bukan pasien psoriasis vulgaris (1202,37 Â± 67,06 pg/ml) denganÂ nilai p<0,05. Penelitian ini menyimpulkan bahwa terdapat perbedaan yang bermakna antara kadar BDNF serum pasien dan bukan pasien psoriasis vulgaris.Â Â Â Â Â Â Â Kata Kunci: psoriasis vulgaris, brain-derived neurotrophic factor
Mikosis Fungoides Folikulotropik Disertai Ko-Ekspresi Pan B-Cell Markers Dengan Manifestasi Klinis Berupa Facies Leonina
Authors: Sutedja Eva Krishna , Febrina Dia , Rohana Erfina , Roslina Nina , Agusni Jono Hadi , Fadjari Trinugroho Hari 
Published: May 2019

Mikosis fungoides folikulotropik (MFF) merupakan varian dari mikosis fungoides (MF)Â dengan perjalanan klinis yang lebih agresif dan prognosis lebih buruk dibandingkan MF klasik. Facies leonina (FL) merupakan manifestasi klinis yang sangat jarang ditemukan pada MFF. CD20 dan CD79a merupakan pan B-cell markers yang sangat jarang ditemukan pada kasus cutaneous T-cell lymphoma (CTCL), termasuk di dalamnya MFF. Dilaporkan satu kasus MFF pada seorang laki-laki berusia 51 tahun dengan manifestasi klinis FL dan madarosis disertai papula folikel menyerupai lesi keratosis pilaris pada dada, punggung, kedua lengan, dan paha. Diagnosis MFF pada pasien ini ditegakkan berdasarkan pemeriksaan histopatologis sediaan biopsi kulit wajah yang menunjukkan gambaran folikulotropisme. Pada pemeriksaan imunohistokimia ditemukan fenotipe CD3 yang dominan, CD4, CD8, CD30, dan Ki-67 lebih dari 40% sel tumor. Penanda sel-B juga ditemukan positif pada beberapa sel yaitu CD20, CD79a, dan bcl-2. Setelah dua bulan diterapi dengan kortikosteroid topikal tidak didapatkan pendataran pada lesi FL. Pasien direncanakan pemberian regimen kemoterapi siklofosfamid, doxorubicin, vincristine, dan prednison. Mikosis fungoides folikulotropikÂ dapat bermanifestasi klinis FL. Fenotipe CD20 dan CD79a pada kasus ini bukan merupakan cutaneous B-cell lymphoma karena fenotipe CD3, CD4, dan CD8 yang ditemukan lebih dominan. Folikulotropisme menyebabkan MFF kurang responsif terhadap skin-targeted therapies sehingga membutuhkan terapi yang lebih agresif. Kata kunci: facies leonina, mikosis fungoides folikulotropik, pan-B cell markers
The impact of environmental factors on the measurement of the normalized difference vegetation index
Authors: Attila Dobos  , Róbert Víg  , János Nagy  
Published: May 2019

The level of nitrogen supply of a plant population can be quickly measured with non-destructive optical measurement devices and the differentiated determination of nitrogen shortage and the replenishment of nitrogen can also be carried out. The level of nitrogen supply is based on the fact that the chlorophyll content of crops is in close correlation with nitrogen content and that the amount of chlorophyll can be easily measured on the basis of the light absorption of chlorophyll molecules. The successfulness of optical measurements can be influenced by the change of weather parameters; therefore, it is important to know the correlations between measurement results and weather parameters when it comes to practical use.The GreenSeeker Model 505 measurement device determines the relative chlorophyll content in the form of the Normalized DifferenceVegetation Index (NDVI) calculated on the basis of the intensity of the reflected red and infrared rays of light from the crop population. The measurements were performed in alfalfa population with 10 replications at five measurement heights and four measurement times. The weather parameters were measured by a weather station located in the middle of the alfalfa population and the correlations between the meteorological data and the NDVI values were examined. During the statistical evaluation of the results, it was established that the NDVI measurement is primarily influenced by the relative humidity of the air, secondly by air temperature and thirdly by wind speed. Relative humidity was in strong correlation with the NDVI values which were also influenced by the measurement height and time. Regression was not significant in the case of 20 cm measurement height, but the measurements above 40 cm height showed significant correlations. The correlation was shown to be strong at each measurement time, but the influence of humidity was the lowest at 11:00 and 14:00.
Alternatives of microclimate control in orchards
Authors: László Lakatos  , János Szél  , József Nyéki  , Zoltán Szabó  , Miklós Soltész  
Published: May 2019

The aim of the study was to find out which of the methods used to avoid damages of late frosts would be the most effective for the fruit growing practice. We tested the antifrost irrigation method in Debrecen-Pallag. For that purpose microjet sprayers are used, which are thrifty and does not need for that purpose large containers. With the aim to secure an even distribution of water, the sprayers are distributed on three levels: above and inside of the crown as well as on the level of trunks. On a large scale, a single microjet above the crown level would be sufficient. By means of a detailed analysis served to set the optimum intervals between spraying phases: with each 15, 10, 5 and 3 minutes during half a minute. The synchronous presence of water and ice below the freezing point, the released freezing heat plus the water used much above the freezing point(9–10 °C) altogether maintains the temperature above around 0 °C near the flowers or growing fruitlets, meanwhile, the surrounding air cools down to -8 °C. The effectiveness of the generally used antifrost would be increased substantially by the former application of cooling irrigation, which delays the blooming date.
PENGARUH PROFESIONALITAS DAN MOTIVASI BERPRESTASI TERHADAP KEPUASAN KERJA DOSEN DI STBA
Authors: Laksananto Tito 
Published: May 2019

<p>Penelitian ini bertujuan untuk mengetahui hubungan antara (1) Profesionalitas Dosen; dan (2) Motivasi Berprestasi; secara bersama-sama dengan (3) Kepuasan Kerja <em>Kepuasan Kerja </em><em>Dosen</em><em> </em><em>S</em><em>TBA</em>. Penelitian dilaksanakan pada <em>S</em><em>TBA</em>, dengan metode penelitian survey dengan analisis korelasional. Populasi penelitian ini dosen berjumlah 225 orang dan yang dijadikan sampel sebanyak 75 orang dosen (30 untuk ujicoba dan 45 untuk penelitian), dipilih berdasarkan teknik acak sederhana (<em>simple random sampling</em>). Penelitian ini menggunakan tiga variabel yaitu, (1) Kepuasan Kerja Dosen (Y), (2) Profesionalitas dosen (X<sub>1</sub>) dan (3) Motivasi Berprestasi (X<sub>2</sub>). Sebelum instrument digunakan, terlebih dahulu dilakukan uji coba instrument. Validitas yang digunakan untuk instrument Kepuasan Kerja dosen, Profesionalitas dosen dan Motivasi Berprestasi adalah validitas konstruk. Demikian juga koefisien reliabilitas instrumen Kepuasan Kerja Dosen, Profesionalitas dosen dan Motivasi Berprestasi dicari dengan rumus alpha cronbach (KR-21) Dalam penelitian ini terdapat tiga kesimpulan pokok, yaitu (1) terdapat hubungan positif antara Profesionalitas dengan Kepuasan Kerja Dosen <em>S</em><em>TBA</em>, (ry<sub>1</sub>) =0,527 dengan = 37,07 + 0,687 X<sub>1</sub>; (2) Terdapat hubungan Motivasi Berprestasi dengan Kepuasan Kerja Dosen (ry<sub>2</sub>) = 0,566 dengan = 40,73 + 0,787X<sub>2</sub>); dan (3) terdapat hubungan positif antara Profesionalitas Dosen dan Motivasi Berprestasi secara bersama-sama dengan Kepuasan Kerja Dosen (ry<sub>12</sub>) = 0,641 dengan = -6,954 + 0.440X<sub>1</sub> + 0,571X<sub>2</sub>. Kesimpulan : 1) makin tinggi Profesionalitas Dosen, akan makin tinggi pula Kepuasan Kerja Dosen, 2) makin tinggi Motivasi Berprestasi, akan makin tinggi pula Kepuasan Kerja Dosen dan 3) makin tinggi Profesionalitas Dosen dan makin baik Motivasi Berprestasi Dosen secara bersama-sama akan makin tinggi pula Kepuasan Kerja Dosen. Saran agar<strong> </strong>Ketua dapat memotivasi dosen dengan memberikan penghargaan dan pengakuan terhadap prestasi dosen dan dosen menyadari bahwa kepuasan kerja tidak hanya ditentukan oleh penghasilan yang diperoleh.</p><strong>Kata Kunci : </strong>Profesionalitas, Motivasi Berprestasi, Kepuasan Kerja Dosen
“Pahit”nya garam: sebuah studi dramaturgi
Authors: As’ad Achmad Fawaid , Setiawan Achdiar Redy , Mulawarman Aji Dedi , Kamayanti Ari 
Published: May 2019

Abstrak
Artikel ini menelaah tentang ketertindasan petani garam di Pamekasan Madura. Melalui pendekatan dramaturgi, terungkap kuasa tengkulak dan perusahaan di balik tengkulak mulai dari sebelum proses produksi hingga penjualan garam rakyat. Petani garam tidak mempunyai wewenang untuk menentukan harga jual garam. Tengkulak garam mempunyai otoritas untuk memasok garam ke perusahaan garam dan menekan harga dari petani atas dasar interaksi sosio-budaya. “Pahit”nya garam bagi petani turut dipicu oleh kebijakan pemerintah yang tidak pro petani garam, termasuk kebijakan garam impor yang semakin menekan harga garam rakyat.

Abstract
This article examines the oppression of salt farmers in Pamekasan Madura. Through discussing dramaturgy, it was revealed the power of middlemen and companies behind middlemen starting from the production process to selling salt of the people. Salt farmers do not have the authority to determine the selling price of salt. Salt middlemen have the authority to supply salt to salt companies and transfer prices from farmers on the basis of socio-cultural relations. The "bitter" salt for farmers is also triggered by government policies that are not pro salt farmers, including important salt policies that increasingly increase people's salt prices.
Mengintai akuntansi dari balik topeng malang
Authors: Darti Djuharni , Yudi Yudi , Lutfillah Novrida Qudsi 
Published: May 2019

Abstrak
Tujuan penelitian adalah untuk mengintai makna akuntansi dari balik tari topeng Malangan. Penelitian ini merupakan penelitian kualitatif menggunakan metafora tontonan, tuntunan dan tatanan tari topeng. Hasil Penelitian menunjukkan tontonan dalam akuntansi dapat dilihat oleh penggunanya melalui laporan keuangan. Kondisi ini bisa dikaitkan dengan Neraca yang tampak pada keseimbangan debet dan kredit. Tatanan penyajian laporan keuangan juga memuat aturan yang harus diikuti dan ditaati berdasarkan standar akuntansi yang berlaku umum seperti standar akuntansi keuangan (SAK) dan SAK_ETAP. Laporan keuangan harus pula mengandung tata nilai atau norma yang merupakan tuntunan dan diperlukan dalam menyusun laporan keuangan.

Abstract
The aim of the study was to stalk the accounting meaning from behind the Malangan mask dance. This research is a qualitative research using spectacle metaphor, guidance and order in mask dance. Research Results show the spectacle in accounting can be seen by users through financial statements. This condition can be corrected with a balance sheet that appears on the debit and credit balance. The order of presentation of financial statements also announces rules that must be followed and adhered to based on generally accepted accounting standards such as financial accounting standards (SAK) and SAK_ETAP. Financial statements must also contain a value or norm that completes and needs to complete financial statements.
EFEKTIFITAS PELAKSANAAN ALOKASI DANA DESA BERDASARKAN PERMENDAGRI NO 113 TAHUN 2014 TENTANG PENGELOLAAN KEUANGAN DESA
Authors: Putra L. M. Ricard Zeldi 
Published: May 2019

The Organization of the Government of the village of terpisakan no peyelenggaraan autonomous region. Through law No. 6 Year 2014 about villages, each village given discretion to set its own kewenanganya, either the authority based on the origin of the local scale, the powers and authority of the village, in the transferred by the Central Government/provinces//kota in accordance with government legislation. This research uses the normative-empirical type. The data used in this research is the primary data, namely data obtained directly from the field in the form of interviews and questionnaires and secondary data, namely data obtained from graphical documents (tables, notes, meeting, meetings, etc), photographs, films, video recordings, and other things that can enrich the primary data. Research results show that implementation of the allocation of Funds in the village of Banabungi Village have been implemented but in pelaksanaanya is not effective. It is based on is Not dilaksanakanya the principle of transparency and participatory in its own ruling, a factor pelaksanaanya i.e. the absence of legal sanctions or force power for the Government when the village does not implement legal norms. While the position of Permendagri NO. 113 Year 2014 about financial management is in compliance as regulations, although the above provision does not mention explicitly the type of legislation in the form of a regulation of the Minister, but the phrase rules set by Ministers at the top, reflecting the existence of ministerial regulation as one of the types of legislation.