bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of interstitial edema in patients with intermediate function of the left ventricle after resolving of acute decompensation of heart failure
Authors: Skorodumova E. G. , Kostenko V. A. , Skorodumova E. A. , Siverinа A. V. 
Published: October 2018

Background.According to the recommendations of the European Society of Cardiology, ultrasound examination of the lung can be used to assess congestive changes, however, this method has so far a low recommendation class IIb and a level of evidence C, which can be regarded as a consequence of its insufficient knowledge.The aim of the research.To study ultrasound characteristics of the lung tissue in patients with intermediate left ventricular function after resolving of acute decompensation of heart failure.Materials and methods. The ultrasound profile of the lung tissue was studied in 71 patients after resolution of acute heart failure decompensation under intermediate left ventricular function. The average age of patients studied was 65.2 ± 3.6 years. 64.3% of them were males ,25.7%-females. Using the ultrasonic method, B-lines were studied, the distance between them being 3 mm and 7 mm in a semi-quantitative manner, according to the method of E. Picano in 2016. The results were statistically processedResults.In persons after the acute decompensation of the heart failure residual congestion persisted with interstitial component dominated in both lungs. Appearance of interstitial lung edema to be considered as prognostic factor of re-hospitalizations rate increasing.Conclusion.Interstitial congestion in the pulmonary parenchyma considered as a factor in the deterioration of the clinical course of heart failure sign of its acute decompensation. In this connection, it is interesting to identify interstitial pulmonary edema at the early stage to prevent real clinical presentation of acute decompensation of the heart failure.
Data Quality Management in e-Health Integration Platforms: the Case of Uruguay
Authors: González Laura , Pidre Silvana , Ruggia Raúl , Serra Flavia , Mendoza Rodrigo , Piñatares Mauricio , Granja Nicolás 
Published: October 2018

Healthcare organizations increasingly need to integrate their software systems with each other in order to exchange clinical data and carry out healthcare processes in coordinated ways. Integration platforms provide mechanisms, based on advanced middleware technologies like the Enterprise Service Bus (ESB), in order to facilitate such integration. In addition, data quality in the healthcare area is critical to take timely and accurate decisions for the health and well-being of patients. This paper propose a solution for data quality management in the context of the Uruguayan e-health integration platform. The proposal comprises a data quality model, that includes quality characteristics identified from dierent types of sources, and extensions to an ESB-based integration platform which allows assessing and enforcing data quality requirements in inter-organizational data exchanges. The proposal was completely prototyped which allowed validating the technical feasibility of the proposed solution.
The use of principal component analysis for the assessment of the spatial variability of curative waters from the Busko-Zdrój and Solec-Zdrój region (Poland) – preliminary results
Authors: Wątor Katarzyna , Kmiecik Ewa , Lipiec Iwona 
Published: October 2018

Abstract
In the Busko-Zdrój and Solec-Zdrój region (Poland), curative waters with different concentrations of sulphur(II) compounds are extracted. In this paper, waters from 14 intakes were considered. The waters analysed are chloride-sodium, sulphide, iodide (Cl–Na, S, I) or chloride-sodium, sulphide (Cl–Na, S) and are especially associated with deep circulation systems (Jurassic limestones) or shallow circulation systems mostly connected with Cretaceous formations (Senonian marls and limestones and Cenomanian sands and sandstones). The aim of this research is to evaluate the similarities or differences between samples of curative water taken from different geological formations and locations. Principal component analysis was used to assess the similarities between samples of curative waters collected from the intakes being examined. Two principal components were extracted. The analysis indicated that there is a difference between the chemical composition of waters taken from different stratigraphies. Water samples from Cretaceous formations of Cenomanian and Senonian age are similar. There is a small difference observed for waters abstracted from the Neogene and Cretaceous. However, these differences mostly resulted from SO42− and Ca2+ concentrations.
Activation of the Glutathione Peroxidase by Metformin in the Bile-duct Ligation induced Liver Injury: In vivo Combined with Molecular Docking Studies
Authors: Mansourian Mahboubeh , Sadeghi Hossein , Doustimotlagh Amir Hossein 
Published: October 2018

Background:
Inhibition of hepatic fibrosis is an attainable objective in managing the chronic liver
disease. The present study aimed to investigate possible defensive effects of metformin on the activities of antioxidant
enzymes, hydroxyproline content, and biochemical factors in bile duct ligation (BDL)-induced cholestatic
rats. The interactive behavior of metformin with glutathione peroxidase (GPx) enzyme was also explained by
molecular docking and conformation characterization.

Methods:
The present study was conducted on 28-adult male Wistar rats classified into four 7-animal groups:
sham-control, mere BDL, and BDL+ metformin that received daily metformin as gavage in two doses of 250 and
500 mg/kg bw for 10 days. Biochemical analysis, hydroxyproline content, and antioxidant enzymes activity were
also determined.

Results:
The hydroxyproline content significantly increased, but the GPx enzyme activity significantly decreased
in the hepatic tissue following BDL, indicating that an oxidative stress-related model in rats was successfully
constituted. Administration of metformin at two doses attenuated hydroxyproline content in the cholestatic liver
and ameliorated the depletion of GPx enzyme activities compared to the non-treated BDL group (P-value ≤ 0.05).
Molecular docking study provides the evidence for metformin ability to regulate enzymatic activity of GPx.

Conclusion:
The research data indicated that due to novel hepatoprotective effects of metformin in an animal
model with BDL-induced liver injury, it was a potential beneficial therapeutic agent for treating the cholestatic
liver disease. The main mechanism might contribute to antioxidant actions, particularly via GPx enzyme.
Safety of Vinflunine in Patients with Advanced Urothelial Carcinoma Refractory to Platinum-based Chemotherapy: A Prospective Pilot Study
Authors: Abdel-Malek Raafat , Shohdy Kyrillus S. , Abbas Noha , Ismail Mohamed , Hamada Emad , Abdel-Kader Yasser 
Published: October 2018

Background:
Several single chemotherapeutic agents have been evaluated as the second-line
treatment of advanced urothelial carcinoma. Despite encouraging efficacy outcomes, toxicity has often
led to dose modifications or discontinuation. We aimed to assess the safety of vinflunine in a particular
population of advanced transitional cell carcinoma of urothelium (TCCU), that were exposed to the
previous toxicity of chemotherapy.

Methods:
This is an open-label, prospective, single-center pilot study to evaluate the response rate and
safety profile of vinflunine in patients with advanced TCCU. It was planned to enroll 25 evaluable
patients. Eligible patients are those with progressive disease after first-line platinum-based regimen for
advanced or metastatic disease.

Results:
The study was prematurely closed due to two sudden deaths that were judged by the review
board as treatment-related. Only ten patients were evaluated and received at least one cycle of
vinflunine. All but one were male and seven underwent radical surgery. Eight had a distant metastasis
(mainly lung and/or liver). Disease control rate was 40%, four patients had a partial response with
median duration of response of 3.5 months. The median overall survival was 3.2 months (95% CI:1.67-
4.73). There were three serious adverse events namely two sudden deaths and one grade 4
thrombocytopenia. Nine grade 3/4 adverse events occurred. The most common all-grade adverse events
were fatigue (50%), constipation (40%) and vomiting (40%). Moreover, grade 3 fatigue occurred in
30% of patients. Only one patient, who achieved PR for 5 months, was fit to receive further cytotoxic
chemotherapy.

Conclusion:
The activity of vinflunine in advanced urothelial carcinoma came at the expense of its
safety. The use of vinflunine has to be limited to the selected group of patients. However, this is a
single institute experience in a limited number of patients.
Immunization of Mothers of Children with Cerebral Palsy in Rural Bangladesh
Authors: Khan Arifuzzaman , Ashher Fahim , Karim Tasneem , Fatema Aneeka , Jahan Israt , Muhit Mohammad , Dey Aditi , Beard Frank , Khandaker Gulam 
Published: October 2018

Background:
Vaccination is one of the most effective public health tools for the
prevention of infectious diseases, morbidity and disability. Little is known about the rate of maternal
immunization among mothers of children with Cerebral Palsy (CP), as well as any possible
role of maternal immunization in development of CP in the newborns.

Objective:
To determine the socio-demographic characteristics and self-reported vaccination
status of mothers of children with CP and compare vaccination coverage in this cohort with national
data on immunization. The study also aims to assess the vaccination status of children with
CP.

Methods:
A subset of the Bangladesh CP Register (BCPR) cohort of women who had children
with CP were recruited during April 2017 from a community based early intervention and rehabilitation
program going on in Shahjadpur. Socio-demographic characteristics and maternal immunization
status were assessed using a semi-structured questionnaire. The vaccination status of
the children was also assessed by interviewing mother and observing the BCG marks. All data
were compared with the corresponding information among general population using national vaccination
coverage survey reports of the Ministry of Health and Family Welfare, Bangladesh.

Results:
Sixty-eight mothers were interviewed of which 17.6% of mothers reported not receiving
any vaccine during pregnancy. Tetanus vaccine was most commonly (82.0%) received during
pregnancy. Overall coverage for at least two doses of tetanus toxoid (TT) among mothers of children
with CP was significantly lower than the national tetanus coverage (79.4% versus 96.4%,
p<0.01). Forty-two (61.7%) mothers with a child with CP reported having not received tetanus
vaccine during their pregnancy compared to only twenty (29.4%) mothers with healthy children
reported missing tetanus vaccination during their pregnancy. This difference was statistically significant
(p<0.01). Hepatitis B and influenza vaccine were received by mothers of children with CP
during the antenatal period (2 and 6 respectively).

Conclusion:
Immunization among mothers of children with CP is significantly poorer than the national
coverage. Also, the immunization of the children with CP is poorer than the national EPI
coverage. Our findings reflect the necessity for specific strategies to improve the vaccination coverage
among mothers of children with disabilities especially CP and the children with CP.
Hepatitis B Seroepidemiology in Australia, One Decade After Universal Vaccination of Infants and Adolescents
Authors: Lu Xinting , Quinn Helen E. , Menzies Rob I. , Hueston Linda , Gilbert Lyn , McIntyre Peter B. 
Published: October 2018

Background:
This study assessed the impact of the staged introduction of universal infant
and adolescent catch-up hepatitis B vaccination programs on the prevalence of immunity and
past hepatitis B virus (HBV) infection in targeted cohorts over almost a decade in Australia.

Methods:
We compared the prevalence of immunity in relevant cohorts of children and adolescents
in repeated national serological surveys conducted in 1998-99, 2002 and 2007. Residual sera
(n =2210) collected opportunistically from Australian laboratories in 2007 were tested for antibody
to hepatitis B surface antigen (anti-HBs) indicating vaccine-induced immunity; sera from individuals
aged 12-29 years with anti-HBs detected (n =386) were then tested for hepatitis B core
antibody (anti-HBc) to identify past hepatitis B infection.

Results:
In 2007, compared with the baseline period of 1998-99, anti-HBs prevalence had increased
significantly in all age groups below 24 years, by more than double in target children.
Prevalence of anti-HBc was zero in the 12-14 years and reduced by 71% in those aged 15-19
years. The hepatitis B vaccination protected a significant number of targeted adolescents with a
modest vaccine uptake (57% to 60% nationally).

Conclusion:
In a setting without incentives or school entry requirements, adolescent vaccination
coverage was significantly higher when delivered by school-based rather than GP-based mechanisms.
A cohort of children was growing up in Australia with a high prevalence of vaccineinduced
immunity against hepatitis B, providing the best opportunity for controlling HBV infection
in Australia.
Maximising Refractive Outcomes with an Extended Depth of Focus IOL
Authors: Power Barry , Murphy Rory , Leccisotti Antonio , Moore Tara , Power William , O’Brien Paul 
Published: October 2018

Objective:To assess the impact of the magnitude of preoperative and postoperative corneal astigmatism on refractive outcomes in patients undergoing cataract surgery or lens exchange with an extended depth of focus intraocular lens. To compare visual outcomes of steep and temporal on-axis corneal incisions.Setting:Department of Ophthalmology, Blackrock Clinic, Dublin, Ireland.Design:Prospective cohort analysis.Methods:Fifty-three consecutive adult patients (94 eyes) undergoing routine phacoemulsification with Symfony IOL implantation were analysed. Exclusion criteria: targets for mini-monovision, incomplete data, other ocular pathology. Data were prospectively collected on pre- and postoperative refraction, keratometry, distance vision, near vision, surgical wound site and Surgically Induced Astigmatism (SIA).Results:The average postoperative monocular Uncorrected Distance and Near visual acuities (UDVA and UNVA) were 0.12 LogMAR (± 0.1) (6/7.5+1) and 0.34 LogMAR (± 0.09) respectively. The average binocular UDVA and UNVA were 0.05 (± 0.07) and 0.29 LogMAR (± 0.06) respectively. Low levels of preoperative corneal astigmatism (0-0.99 D) were associated with better LogMAR UDVA and UNVA when compared with higher levels (> 0.99 D): 0.11 (CI 0.103-0.107)vs.0.206 (CI 0.122-0.290) (p=0.015, CI 95%) and 0.33 (CI 0.316 - 0.356)vs.0.39 (CI 0.34-0.43) (p=0.034, CI 95%) respectively. When patients with steep on-axis corneal incisions were compared with temporal on-axis corneal incisions, no difference was detected in visual outcome or SIA.Conclusion:The Symfony IOL is an effective surgical means of addressing presbyopia and reducing postoperative spectacle dependence. We stress caution when offering potential spectacle independence for patients with over 1D of preoperative corneal astigmatism as these patients achieve statistically significantly inferior and less predictable visual results.
Modernos y descentrados: una redefinición del espacio y del poder cívico religioso en dos pueblos Chuj (Huehuetenango, Guatemala)
Authors: Piedrasanta Herrera Ruth 
Published: October 2018

En este trabajo se señalan las graves tensiones y rupturas producidas por dos momentos ligados a la modernización en el espacio grupal chuj. Estos momentos han afectado profundamente el poder de las autoridades civiles y religiosas y con ello la representación y la gestión real y simbólica de un espacio grupal distintivo. Para entender estos procesos, se examinan ciertos rituales calendáricos, en particular el de la profecía ocurrida al final del Oyeb’ku. Ésta sitúa un escenario posible para un nuevo ciclo temporal en un espacio ligado al territorio y geografía sagrada, donde se contempla la injerencia de factores externos que atañen a los chuj. A la vez, este rito constituye un acto de reinstauración de un orden espaciotemporal que les resulta propio. Actualmente, con la ruptura entre autoridad civil y religiosa, se despliegan unidades más discretas encargadas de restablecer el frágil orden de un mundo centrado y en equilibrio, en medio de un contexto global, desordenado y difuso.Abstract: In this paper I point out the severe tensions and ruptures generated in two moments linked with the modernization of chuj collective space. These moments have deeply affected the power of civil and religious authorities, and therefore the representation and management of real and symbolic collective space. With this aim, I examine certain calenderic rituals, in particular those that occur in the prophecy made at the end of the Oyeb’ku. This prophecy of the New Year places a possible scenario for a new temporal cycle in the space associated to chuj territory and sacred geography, where the interference of external factors is considered. This ritual also reestablishes chuj spaciotemporal order. With the rupture between civil and religious authorities, smaller and more separate units open out in the restoration of a focused and balanced world order, although fragile, in the midst of a global, diffused, and jumbled context.Résumé : Dans ce travail, on note les graves tensions et ruptures produites dans deux moments liés à la modernité de l’espace des Chuj. Ces moments ont profondément affecté le pouvoir des autorités civiles et religieuses ainsi que la représentation et gestion réelle et symbolique d’un espace qui identifie les Chuj en tant que groupe. Pour comprendre ces processus, l’article examine des rituels chuj liés au calendrier sacré et en particulier la prophétie du nouvel an. Celle-ci situe un scénario possible pour le nouveau cycle temporel dans un espace lié au territoire et à la géographie sacrée, où la participation de facteurs externes est intégrée. Aussi, le rite en question constitue un acte de réinstauration d’un ordre spatio-temporel distinctif. Actuellement, avec la rupture entre autorités civiles et religieuses, des unités discrètes se sont mises en place pour répondre au besoin de rétablir un ordre centré et en équilibre, même fragile, au milieu d’un contexte global, désordonné et diffus.
Hubungan Asupan Cairan Ibu Hamil terhadap Indeks Cairan Amnion
Authors: Fatmawati Eny , Hadiati Diah Rumekti , Pradjatmo Heru 
Published: October 2018

Introduction: Adequate amniotic fluid volume is a requirement for intra uterine fetal development and good pregnancy outputs / neonatal. Adequate intake of fluid in pregnant women can increase both the amniotic fluid index on oligohydramniotic or normoamniotic, but the scientific basis for the adequacy of the recommended daily fluid have not clear yet. Furthermore, the fluid intake counseling in addition to nutrition for pregnant women is neededObjective: To determine the fluid intake in pregnant women and the mean difference of amniotic fluid index on adequate fluid intake compared to less fluid intake.Methods: This research used prospective observational cohort study, conducted against the third semester pregnant women in Puskesmas Mergangsan and Tegalrejo Yogyakarta during July until September 2014. The subjects who met the inclusion criteria were divided into adequate and less fluid intake groups. The correlation between fluid intake and amniotic fluid index was analyzed using t-test and linear regression.Result and Discussion: The total subjects who met the criteria were 27 people, consist of 12 people in adequate fluid intake group and 15 people in less fluid intake group. The mean of subject’s fluid intake 2078 ml (enough), while the mean of amniotic fluid index (AFI) 12,76 cm (normoamniotic).The result showed that there was a significant difference (3,50 cm (IK 95%; 1,5-5,48); P < 0,05) between the mean of AFI from adequate fluid intake group compared to less fluid intake group . Simple linear regression test showed the effect of fluid intake for AFI namely 31,7%; with the amount of predicted AFI = 10,686 + 3,545 x fluid intake – 1,015 x age – 1,317 x education + 0,314 x occupation (ARS= 44,5%). External variables (age, education, and occupation) had no significant effect for AFI .Conclusion : The mean preview of fluid intake in the third semester pregnant women in Yogyakarta was adequate. Moreover, there was a AFI signifficant difference between adequate fluid intake compared to less fluid intake. Keywords: fluid intake; amniotic fluid index; AFI
PHYSICAL TREATMENT OF SPORTS KNEE INJURIES
Authors: Krstić Olivera , Stamatovic Milovan 
Published: October 2018

The development of sports medicine and rehabilitation with the great involvement of techniques and modern technology have increased the needs and possibilities for quick diagnosis and more adequate treatment. Regular companions of sports activities are sport injuries of various parts of the body, depending on the type and conditions in which sport activity is performed. In this paper, we analyzed knee injuries because they are the most dominant. The knee, which is the largest, the most complex and the most stressed joint, is most exposed to injuries. We analyzed 124 respondents who were treated in the Ribarska Banja, by physical and balneological treatment, during the period 2005-2006. Anamnestic data, as the most common cause of injury, include insufficient training, insufficient physical preparedness, rough start of an opponent or uneven terrain. The knee joint is the most commonly injured region in athletes, and because of the complexity of the joint itself, these injuries are very complicated. Balneal treatment showed positive effects on healing and accelerated return to the field. Balneo Climatic Treatment is always accompanied with certain methods of physical therapy and rehabilitation, and all of them together can accelerate healing. The successful return to the field depends on the applied therapeutic methods and on an early beginning of therapeutic treatment.
THE PROBLEMS OF THE SYSTEM CLASSIFICATION OF RELIGIONS
Authors:  Alikberov A. K. 
Published: October 2018

The article is devoted to the system classiﬁ cation of religions on the basis of various criteria, the most important of which is the communication one. As the cross-cultural method shows, there is no word «religion» in many languages o f the world, but there is its equivalent, denoting the connection of man with God and supernatural forces. The system classiﬁ cation of religions is more a system of classiﬁ cations than a classiﬁ cation, which based on ideal, hypothetical models. It based on the object of worship (the religion of Nature, the religion of Tradition, the religion of Revelation), on the sources of the doctrine (the religion of the scriptures), on the methods of obtaining information, or, in the religious paradigm, religious knowledge /hidden truths (prophetic, non-prophetic, etc.). The author tries to ﬁ nd conjugations between these classiﬁ cations. The system-communication method is one of many possible ways of scientiﬁ c knowledge of religion, which allows us to divide complex social essences and phenomena into composite elements, and each of them in their close interconnection and interaction with other elements of systematic knowledge, taking into account the speciﬁ city of religious communication.