bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutral variation does not predict immunogenetic variation in the European grayling (Thymallus thymallus)—implications for management
Authors: Vanessa Huml J. , Taylor Martin I. , Edwin Harris W. , Sen Robin , Ellis Jonathan S. 
Published: September 2018

AbstractPreservation of genetic diversity is critical to successful conservation, and there is increasing demand for the inclusion of ecologically meaningful genetic information in management decisions. Supportive breeding programmes are increasingly implemented to combat declines in many species, yet their effect on adaptive genetic variation is understudied. This is despite the fact that supportive breeding may interfere with natural evolutionary processes. Here, we assessed the performance of neutral and adaptive markers (major histocompatibility complex; MHC) to inform management of European grayling (Thymallus thymallus), which routinely involves supplementation of natural populations with hatchery‐reared fish (stocking). This study is the first to characterize MH II DAA and DAB loci in grayling and to investigate immune genetic variation in relation to management practice in this species. High‐throughput Illumina sequencing of “introduced,” “stocked native” and “non‐stocked native” populations revealed significantly higher levels of allelic richness and heterozygosity for MH markers than microsatellites exclusively in non‐stocked native populations. Likewise, significantly lower differentiation at the MH II than for microsatellites was apparent when considering non‐stocked native populations, but not stocked populations. We developed a simulation model to test the effects of relaxation of selection during the early life stage within captivity. Dependent on the census population size and stocking intensity, there may be long‐term effects of stocking on MH II, but not neutral genetic diversity. This is consistent with our empirical results. This study highlights the necessity for considering adaptive genetic variation in conservation decisions and raises concerns about the efficiency of stocking as a management practice.
Improved lung function at age 6 in children born very preterm and fed extra protein post‐discharge
Authors: Toftlund Line Hedegaard , Agertoft Lone , Halken Susanne , Zachariassen Gitte 
Published: September 2018

AbstractBackgroundIn very preterm‐born children, alveolar maturation is challenged and lung function is often compromised during childhood. So far, very few studies have focused on type of early nutrition and lung function in children born preterm.MethodsThis study is a 6 years follow‐up of 281 very preterm‐born infants (VPI) with a gestational age (GA) <32 + 0 weeks. Infants breastfed at discharge from hospital were randomized to unfortified (UHM) or fortified (FHM) mother's (human) milk, whereas those not breastfed received a preterm formula (PF). The intervention lasted until 4 months corrected age. At 6 years of age fractional exhaled nitric oxide (FeNO), airway resistance and occlusion measurements with reversibility were performed. Data on predisposition to asthma and allergy as well as possible allergic symptoms of the child were obtained with questionnaires.ResultsOutcome data was fully or partially available on 160 (66.9%) of 239 children. This included 49 (30.6%) children fed UHM, 58 (36.3%) fed FHM and 53 (33.1%) fed PF. Successful FeNO measurements were obtained in 119 (74.4%) children and airway resistance measurements in 160. FeNO results were not significantly different between feeding groups. Children fed a protein‐enriched diet (FMH/PF) had the lowest, for example, best, airway resistance; FHM‐fed had lower values than UHM‐fed (P = 0.042) before, and PF‐fed had significantly lower values than UHM‐fed after beta‐2‐agonist inhalation (P = 0.050). The tendency of lower airway resistance when protein enriched were the same in gender‐specific analyses. In SGA children, the same tendency was found between PF‐ and UHM‐fed (P = 0.007 before and P = 0.046 after beta‐2‐agonist inhalation). All values were within reference limits.ConclusionsLung function in very preterm‐born children may improve when fed a protein‐enriched nutrition post‐discharge.
Integration of two herbivore‐induced plant volatiles results in synergistic effects on plant defence and resistance
Authors: Hu Lingfei , Ye Meng , Erb Matthias 
Published: September 2018

AbstractPlants can use induced volatiles to detect herbivore‐ and pathogen‐attacked neighbors and prime their defenses. Several individual volatile priming cues have been identified, but whether plants are able to integrate multiple cues from stress‐related volatile blends remains poorly understood. Here, we investigated how maize plants respond to two herbivore‐induced volatile priming cues with complementary information content, the green leaf volatile (Z)‐3‐hexenyl acetate (HAC) and the aromatic volatile indole. In the absence of herbivory, HAC directly induced defence gene expression, whereas indole had no effect. Upon induction by simulated herbivory, both volatiles increased jasmonate signalling, defence gene expression, and defensive secondary metabolite production and increased plant resistance. Plant resistance to caterpillars was more strongly induced in dual volatile‐exposed plants than plants exposed to single volatiles.. Induced defence levels in dual volatile‐exposed plants were significantly higher than predicted from the added effects of the individual volatiles, with the exception of induced plant volatile production, which showed no increase upon dual‐exposure relative to single exposure. Thus, plants can integrate different volatile cues into strong and specific responses that promote herbivore defence induction and resistance. Integrating multiple volatiles may be beneficial, as volatile blends are more reliable indicators of future stress than single cues.
LinkedIn as a new selection method: Psychometric properties and assessment approach
Authors: Roulin Nicolas , Levashina Julia 
Published: September 2018

AbstractVarious surveys suggest LinkedIn is used as a screening and selection tool by many hiring managers. Despite this widespread use, fairly little is known about whether LinkedIn meets established selection criteria, such as reliability, validity, and legality (i.e., no adverse impact). We examine the properties of LinkedIn‐based assessments in two studies. Study 1 shows that raters reach acceptable levels of consistency in their assessments of applicant skills, personality, and cognitive ability. Initial ratings also correlate with subsequent ratings done 1‐year later (i.e., demonstrating temporal stability), with slightly higher correlations when profile updates are taken into account. Initial LinkedIn‐based ratings correlate with self‐reports for more visible skills (leadership, communication, and planning) and personality traits (Extraversion), and for cognitive ability. LinkedIn‐based hiring recommendations are positively associated with indicators of career success. Potential adverse impact is also limited. Profiles that are longer, include a picture, and have more connections are rated more positively. Some of those features are valid cues to applicants’ characteristics (e.g., applicants high on Conscientiousness have longer profiles). In Study 2, we show that an itemized LinkedIn assessment is more effective than a global assessment. Implications of these findings for selection and future research are discussed.
The Brachypodium distachyon UGT Bradi5gUGT03300 confers type II fusarium head blight resistance in wheat
Authors: Gatti M. , Cambon F. , Tassy C. , Macadre C. , Guerard F. , Langin T. , Dufresne M. 
Published: September 2018

Fusarium head blight (FHB), caused by fungi belonging to the Fusarium genus, is a widespread disease of wheat (Triticum aestivum) and other small‐grain cereal crops. The main causal agent of FHB, Fusarium graminearum, produces mycotoxins mainly belonging to type B trichothecenes, such as deoxynivalenol (DON), that can negatively affect humans, animals and plants. DON detoxification, mainly through glucosylation into DON‐3‐O‐glucose, has been correlated with resistance to FHB. A UDP‐glucosyltransferase from the model cereal species Brachypodium distachyon has been shown to confer resistance both to initial infection and to spike colonization (type I and type II resistances, respectively). Here, the functional characterization of transgenic wheat lines expressing the Bradi5g03300 UGT gene are described. The results show that, following inoculation with the fungal pathogen, these lines exhibit a high level of type II resistance and a strong reduction of mycotoxin content. In contrast, type I resistance was only weakly observed, although previously seen in B. distachyon, suggesting the involvement of additional host‐specific characteristics in type I resistance. This study contributes to the understanding of the functional relationship between DON glucosylation and FHB resistance in wheat.
Distribution and phylodynamics of papaya ringspot virus on Carica papaya in Cuba
Authors: Cabrera Mederos D. , Giolitti F. , Torres C. , Portal O. 
Published: September 2018

Orchard and garden papaya crops grown in 47 Cuban municipalities were surveyed from 2008 to 2013, revealing the widespread distribution of papaya ringspot virus (PRSV) in Cuba. Phylodynamic analyses performed with the partial coat protein gene of all Cuban PRSV‐P isolates (34 sequences) and 107 sequences of isolates from the American continent and the Caribbean islands showed a most recent common ancestor in 1942 (95% highest posterior density, HPD 95% = 1911–1967). The substitution rate was estimated to be 7.7 × 10−4 substitutions per site per year (HPD 95% = 4.6 × 10−4 to 1.1 × 10−3), which is equivalent to those detected in other RNA viruses. Demographic reconstruction of PRSV showed that viral diversity increased in the 1985–1990 period, which coincides with the implementation of extensive production practices. Moreover in Cuba, viral dispersion occurred from Mexico and other unknown ancestral locations. The spatiotemporal diffusion analysis proposed Mexico as an ancestral area for the origin of diversification in the American continent and suggests new dispersion events between American and Caribbean isolates. The observed widespread distribution, clear geographic grouping of Cuban isolates, virus growth and genetic diversity provide strong evidence of the PRSV dispersion patterns, which has implications for the control strategies of PRSV.
Between regulatory field structuring and organizational roles: Intermediation in the field of sustainable urban development
Authors: Bothello Joel , Mehrpouya Afshin 
Published: September 2018

AbstractRecent contributions in the domains of governance and regulation elucidate the importance of rule‐intermediation (RI), the role that organizations adopt to bridge actors with regulatory or “rulemaking” roles and those with target or “rule‐taking” roles. Intermediation not only enables the diffusion and translation of regulatory norms, but also allows for the representation of different actors in policymaking arenas. While prior studies have explored the roles that such RIs adopt to facilitate their intermediation functions, we have yet to consider how field‐level structuring processes influence (and are influenced by) the various and changing roles adopted by RI. In this study we focus on the mutually constitutive relations between field‐level change processes and the evolving roles of RIs by studying the rise of the International Council for Local Environmental Initiatives (ICLEI)/Local Governments for Sustainability, an RI serving as a bridge for sustainable urban development policies between the United Nations and local authorities. Using ICLEI as an illustrative case, we theorize four different processes of regulatory field structuration: problematization, role specialization, marketization, and orchestrated decentralization. We discuss their implications for RI roles in the field and further theorize the changing dynamics of trickle‐up intermediation processes as an RI gains power and influence.
Applications of sensory and physiological measurement in oral‐facial dental pain
Authors: Dabiri Darya , Harper Daniel E. , Kapila Yvonne , Kruger Grant H. , Clauw Daniel J. , Harte Steven 
Published: September 2018

AbstractDentists regularly employ a variety of self‐report and sensory techniques to aid in the diagnosis and treatment of tooth‐related disease. Many of these techniques leverage principles borrowed from psychophysics, the quantitative measurement of the relationship between stimuli and evoked sensations, which falls under the larger umbrella of quantitative sensory testing (QST). However, most clinicians fail to meet the bar for what could be considered quantitative sensory testing, and instead focus on qualitative and dichotomous “yes/no” aspects of sensory experience. With our current subjective measurements for pain assessments, diagnosis and treatment of dental pain in young children and individuals (any age) with severe cognitive impairment rely extensively on third‐party observations. Consequently, the limitation of inadequate pain diagnosis can lead to poor pain management. In this review, it discusses mechanisms that underlie acute and chronic dental pain. It details the measurement of somatosensory responses and pulpal blood flow as objective measures of tooth health and pain. It proposes that bridging these varied methodologies will significantly improve diagnosis and treatment of orofacial pain and pathology. It concludes that improving the precision of sensory measurements could yield important improvements in diagnostic challenges in pulpal pathology for noncommunicative and cognitively impaired individuals.
Iowa nursing facility oral hygiene (INFOH) intervention: A clinical and microbiological pilot randomized trial
Authors: Marchini Leonardo , Recker Erica , Hartshorn Jennifer , Cowen Howard , Lynch David , Drake David , Blanchette Derek R. , Dawson Deborah V. , Kanellis Michael , Caplan Daniel 
Published: September 2018

AbstractPurpose/aimThe aim of this pilot study was to evaluate feasibility and gather initial data for a definitive study to test the clinical and microbiological effectiveness of a nursing facility (NF) customized oral hygiene protocol, intended to be delivered by dental hygienists and NF personnel.Materials and methodsA convenience sample of 8 Eastern Iowa NFs was recruited, and each NF was assigned to one of three intervention groups: (1) control (current oral hygiene practice), (2) educational program only, and (3) educational program plus 1% chlorhexidine varnish monthly application. Demographic information, systemic health data, patient centered data, oral health data, and microbiology samples were collected at baseline and after 6 months.ResultsRecruitment response rates were 21% for NFs and 23% for residents. A total of 81 residents were examined at baseline and of those, 49 were examined at 6 months (39.5% attrition). There were no statistically or clinically significant differences among the intervention groups at 6 months for any of the recorded clinical or microbiological outcomes.ConclusionsRecruitment and retention posed a significant challenge to this trial, even with a relatively short observation period. Results from this pilot study did not encourage further investigation of this customized oral hygiene protocol.
Oral features of Griscelli syndrome type II: A rare case report
Authors: Tewari Nitesh , Rajwar Anju , Mathur Vijay Prakash , Chaudhari Prabhat Kumar 
Published: September 2018

AbstractGriscelli syndrome (GS) is an autosomal‐recessive disorder of the vesicle transport and membrane trafficking system first identified by Griscelli et al in 1978. The three types of GS have specific genetic defects and systemic manifestations apart from classic partial pigmentary dilution, resulting in hypopigmentation of skin and silvery hair. GS‐II occurs due to a defect in the Rab27a gene and is characterized by primary immune deficiency along with accelerated phases of a hemophagocytic lymphohistiocytosis (HLH) crisis. This rare disorder has been widely studied for dermatological, hematological, and neurological manifestations; however, the oral features and presentations have not been elucidated in detail. This report presents a case of a 4‐year‐old male with known mutation c.550C > T or p.R184X mutation (ENST00000396307) in Rab27a with oral features.
To be fair, generous, or selfish: The effect of relationship on Chinese children’s distributive allocation and procedural application
Authors: Li Weiwei , Curtis Robin , Moore Chris , Wang Yun , Zeng Xihua 
Published: September 2018

AbstractPrevious research has found that children’s sharing with others relies on fairness norms, but also varies according to their social relationships. The current study focuses on the conflict between fairness and relationship, exploring their impacts across two resource allocation contexts. We used a parallel work task to explore the effect of relationship with different recipients (friend, stranger, or disliked peer) on three allocation patterns (generous, fair, or selfish), when children directly allocated resources (distributive allocation), or applied different procedures to recipients (procedural application). Participants consisted of 123 Chinese children between the ages of 6 and 12. We found that in the distributive allocation context, in which participants directly decided the outcome, children primarily considered their relationship with recipients when dividing resources, not fairness. However, in the procedural application context, in which children could choose different allocation procedures for recipients, children primarily preferred fairness, regardless of social relationship. Moreover, when making distributive allocations, 6‐ to 8‐year‐olds were more selfish toward their disliked peers, whereas 9‐ to 12‐year‐olds tended to be more fair and generous toward their friends and strangers. These findings shed light on the link between social relationship and fairness within different allocation contexts among children of Chinese cultural background.
The Sociolinguistic Repetition Task: A New Paradigm for Exploring the Cognitive Coherence of Language Varieties
Authors: Buson Laurence , Nardy Aurélie , Muller Dominique , Chevrot Jean‐Pierre 
Published: September 2018

AbstractSociolinguistic studies generally focus on specific sociolinguistic variables. Consequently, they rarely examine whether different sociolinguistic variables have coherent orientation in a specific language variety (a social or a regional dialect) or whether the speakers freely mix sociolinguistic variants. While different attempts have been made to identify coherence and mixing in the production or perception of dialects, our aim is to answer this question at the level of the cognitive representation of varieties. For this purpose, we draw on the phenomenon of sociolinguistic restoration: when they repeat sociolinguistically mixed utterances, people tend to make them homogeneous. The first experiment—a repetition task—reproduced sociolinguistic restoration in an experimental setting. The second experiment—a judgment task—ensured that participants perceived the difference between homogeneous and mixed utterances. We conclude that high‐order coherent representations influence the reconstruction of utterances during the repetition task.
Non‐adjacent Dependency Learning in Humans and Other Animals
Authors: Wilson Benjamin , Spierings Michelle , Ravignani Andrea , Mueller Jutta L. , Mintz Toben H. , Wijnen Frank , van der Kant Anne , Smith Kenny , Rey Arnaud 
Published: September 2018

AbstractLearning and processing natural language requires the ability to track syntactic relationships between words and phrases in a sentence, which are often separated by intervening material. These nonadjacent dependencies can be studied using artificial grammar learning paradigms and structured sequence processing tasks. These approaches have been used to demonstrate that human adults, infants and some nonhuman animals are able to detect and learn dependencies between nonadjacent elements within a sequence. However, learning nonadjacent dependencies appears to be more cognitively demanding than detecting dependencies between adjacent elements, and only occurs in certain circumstances. In this review, we discuss different types of nonadjacent dependencies in language and in artificial grammar learning experiments, and how these differences might impact learning. We summarize different types of perceptual cues that facilitate learning, by highlighting the relationship between dependent elements bringing them closer together either physically, attentionally, or perceptually. Finally, we review artificial grammar learning experiments in human adults, infants, and nonhuman animals, and discuss how similarities and differences observed across these groups can provide insights into how language is learned across development and how these language‐related abilities might have evolved.
Effect of topical application of 0.5% proparacaine on corneal culture results from 33 dogs, 12 cats, and 19 horses with spontaneously arising ulcerative keratitis
Authors: Edwards Sydney G. , Maggs David J. , Byrne Barbara A. , Kass Philip H. , Lassaline Mary E. 
Published: September 2018

AbstractObjectiveTo investigate the effect of topically applied proparacaine on bacterial and fungal culture results and to compare cytologic and culture results in patients with ulcerative keratitis.ProcedureCorneal samples were collected from 33 dogs, 19 horses, and 12 cats with spontaneously arising ulcerative keratitis. Samples for bacterial (dogs, cats, horses) and fungal (horses) cultures were collected prior to and following application of 0.5% proparacaine or saline. All patients then received a topical anesthetic, and samples were collected for cytology. Frequency of cultivatable bacteria before (Swab 1) and after (Swab 2) application of proparacaine or saline was compared using Fisher's exact test. Homogeneity of culture and cytology results was assessed using McNemar's test.ResultsNo difference was detected in number of animals from which bacteria were isolated from Swab 1 or Swab 2 for proparacaine (21/37 and 17/37, respectively) or saline (10/27 and 12/27, respectively). Small numbers prevented analysis of fungal culture results in horses between Swab 1 and Swab 2 for proparacaine (2/12 and 1/12, respectively) or saline (both, 1/8). Bacteria were isolated from 10 of 20 horses and detected cytologically in 3 of these; fungi were isolated from 3 of 20 horses and detected cytologically in 2 of these. Bacteria were detected more frequently using culture (31/64) than cytology (19/64).ConclusionProparacaine did not significantly alter bacterial or fungal culture results in cats, dogs, or horses; however, clinical significance warrants investigation. Culture and cytology provided complementary data; both should be performed to maximize organism detection in patients with ulcerative keratitis.