bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogene Hyperthyreose nach Radiojod-Ablation einer fokalen Autonomie
Authors: Boddenberg Barbara , Voth E. , Schicha H. 
Published: March 2018

ZusammenfassungOffenbar tritt nach Ausschaltung von autonomem Schilddrüsengewebe selten eine immunogene Hyperthyreose auf. Es werden einige Patienten mit entsprechendem Krankheitsverlauf beschrieben. Die ursächlichen Zusammenhänge sind noch nicht untersucht und zur Zeit nicht eindeutig erklärbar. Alle bisherigen Publikationen, die eine Koinzidenz von Schilddrüsenautonomie und immunogener Hyperthyreose beschreiben, berichten nicht über die Reihenfolge des Auftretens oder anders als hier über die Entwicklung einer Autonomie im Anschluß an eine Basedow-Hyperthyreose. Die Tatsache, daß die Hyperthyreose innerhalb von wenigen Monaten nach einer RadiojodElimination des autonomen Gewebes aufgetreten ist, untermauert die Notwendigkeit von Kontrollen innerhalb des ersten Jahres nach einer Radiojod-Therapie.
Role of Paramagnetic Ions and Water Proton Spin-Lattice Relaxation Time in Biological Systems
Authors: Akber S. F. 
Published: March 2018

SummaryThis paper summarizes the observations of different studies concerning the influence of paramagnetic ions on spin-lattice relaxation times in magnetic resonance imaging. Based on findings that manganese ion content in cancer tissues is decreased in comparison to normal tissues, the results of different papers analysing the influence of tissue manganese concentration on spin- lattice relaxation times are collected and compared. Neither the comparison between different organs, different animals nor the comparison between different tissues (normal and malignant) showed correlations of practical consequences between manganese concentrations and spin-lattice relaxation times. These results are consistent with those from studies with copper and iron ions in living systems.
Somatostatinrezeptor-szintigraphie bei medullären Schilddrüsenkarzinomen, GEP-Tumoren und Karzinoiden
Authors: Farahati J. , Bier D. , Knust E. J. , Reiners Chr. , Eising E. G. 
Published: March 2018

ZusammenfassungIn dieser Studie wurden 24 Patienten mit medullären Schilddrüsenkarzinomen (MTC) und 10 Patienten mit gastro-entero-pankreatischen (GEP-)Tumoren oder Karzinoiden mittels Somatostatinrezeptorszintigraphie untersucht. Als Radio-pharmakon kamen 123I-Tyr3-Oktreotid 19mal, 111In-DTPA-D-Phe1-Oktreotid (Octreoscan®) 25mal und 99mTc-V-DMSA 14mal zur Anwendung. Die MTC-Pati-enten waren durch das Kalzitonin und/oder das CEA, die übrigen durch Tumornachweis auffällig. Die Octreoscan®-Szintigraphie fiel in 68% aller tumorsuspekten Fälle positiv aus, die123I-Tyr3-Oktreotid-Szintigraphie dagegen in nur ca. 11%. 99mTc-V-DMSA-Untersuchungen bei MTC-Patienten fielen in 23% positiv aus. Lebermetastasen ließen sich bei MTC-Patienten (im Gegensatz zu den GEP-Patienten) nicht nachweisen. Die Ergebnisse lassen Octreoscan® überlegen erscheinen.
Criteria and Quantification of Fibrous Dysplasia on MDP Scanning
Authors: Clauss R. P. , Sathekge M. M. 
Published: March 2018

SummaryEleven patients with histologically proven fibrous dysplasia (biopsy) were imaged with 3-phase bone scanning, using 99mTc-MDP. Ten had monostotic and one had polyostotic fibrous dysplasia. The perfusion (phase I) and uptake (phase III) of monostotic lesions was compared to the normal contralateral side and the rest of the skeleton was inspected for other abnormalities. Lesions presented with slightly increased perfusion (1.65 normal ± 0.907) and markedly increased uptake of tracer (6.0 normal ± 2.58). Other features that were noted are high spinal and scapula and poor renal tracer uptake.
Einfluß einer Hormonsubstitution auf den postmenopausalen Uterus
Authors: Rüdisüli A. , Goetze M. , Leibundgut U. , Nitzsche E. U. , Müller-Brand J. , Otte A. 
Published: March 2018

ZusammenfassungBei der Skelettszintigraphie einer 58jährigen postmenopausalen Frau erkannte man in der Perfusions- und Blood-pool-Phase einen unklaren Fokus erhöhter Aktivität im rechten Becken. Computertomographie und Sonographie des Abdomens, insbesondere des Uterus und der Ovarien, waren unauffällig. Nach eingehender anamnestischer Befragung stellte sich heraus, daß die Patientin unter einer mehrjährigen peroralen ÖstrogenVGestagen-Hormonsubstitutionstherapie zur Osteoporose-Prophylaxe stand, jedoch seit den letzten zwölf Monaten der Therapie über keine menstruationsähnlichen Abbruchblutungen mehr berichten konnte. Bei ihrer Zuweisung befand sich die Patientin am 25. Tag der Hormonsubstitutionstherapie und ihr Uterus somit in einem prämenstruellen Stadium. Trotz Ausbleibens der Blutung bei postmenopausalen Frauen sollte somit an die Möglichkeit der Hormonsubstitution gedacht und danach gefragt werden, wenn in den ersten beiden Phasen der Skelettszintigraphie eine unklare, gut vaskularisierte Struktur im kleinen Becken gefunden wird, bevor weitere diagnostische Schritte unternommen werden.
„Ecstasy“ – die Droge der Techno-Generation
Authors: Freudenmann R. W. 
Published: March 2018

ZusammenfassungDie vorliegende Arbeit liefert eine Einführung zu „Ecstasy“, der Modedroge der Techno-Musik-Generation. Der Schwerpunkt liegt auf klinisch relevanten Informationen. „Ecstasy“ ist der Straßenname für das ring-substituierte Amphetaminderivat 3,4-Methylene-Dioxy-Methamphetamin, kurz MDMA. Mittlerweile wird der Name „Ecstasy“ als Sammelbegriff für MDMA und seine chemisch nur leicht abweichenden Analoga MDA, MDEA und MBDB verwendet. Ausgehend von der Chemie wird der molekulare Wirkmechanismus der Substanzen erläutert. Die psychotropen und peripheren Wirkungen von „Ecstasy“ samt Komplikationen und das Vorgehen bei Intoxikationen werden dargestellt. Zudem werden die wichtigsten pharmakokinetischen Eigenschaften und gefährliche Wechselwirkungen mit anderen Substanzen besprochen. Typische Gebrauchsmuster, neue epidemiologische Gesichtspunkte und juristische Aspekte dieser in Deutschland nicht-verkehrsfähigen Betäubungsmittel werden beschrieben. Abschließend werden mögliche Langzeitfolgen beim Menschen nach schwerem „Ecstasy“-Konsum diskutiert.
One-Stage Reconstruction for Re-rupture of Achilles Tendon with Soft Tissue Infection: Using an Anterolateral Thigh Flap Incorporating a Vascularized Muscle Flap and a Strip of Iliotibial Tract
Authors: Sato Ryosuke , Hibino Naohito , Yamano Masahiro , Yoshioka Shinji , Terai Tomoya , Kita Kenichiro , Hama Shingo , Hamada Yoshitaka , Tonogai Ichiro , Sairyo Koichi 
Published: March 2018

AbstractReconstruction is challenging in a patient with loss of a segment of Achilles tendon and infection in the overlying soft tissue. Here the authors describe one-stage tendon reconstruction, using an anterolateral thigh free flap incorporating a vascularized muscle flap and a strip of iliotibial tract in a patient with re-rupture of an Achilles tendon and soft tissue infection. Postoperative immobilization of the affected ankle using an external fixator enabled us to observe the flap directly and reduce pressure on the flap. The patient had a successful outcome, with no difficulty in walking, running, or climbing stairs and no limitation of range of motion at the ankle joint postoperatively. This is a promising technique for reconstruction of the Achilles tendon and treatment of infection as a one-step procedure.
A Rare Case of Complex Carpal Injury: Divergent Trapezium-Trapezoid Fracture Dislocation
Authors: Harna Bushu , Sabat Dhananjaya 
Published: March 2018

Abstract
Background Divergent trapezium-trapezoid fracture dislocation is a rare and complex injury. The authors present an unusual case of dislocation of the trapezium-trapezoid complex with scaphoid fracture.
Case Description A 25-year-old man suffered a road traffic accident leading to complex carpal injury due to axial and rotation forces (steer wheel injury) on the left wrist. X-rays and computed tomographic (CT) scan were done showing trapezium-trapezoid dissociation with fracture of distal pole of scaphoid and ulna styloid. The second metacarpal base was fractured with many ligamentous injuries in the wrist.
Methods Volar flexor carpi radialis (FCR) approach was used to reduce and fix scaphoid fracture with 2.7-mm cannulated screw. Dorsal approach was used to fix fracture of second metacarpal base and perform reduction in trapezium-trapezoid complex with help of 0.8-mm K-wires, and suspension wiring of first to second and second to third metacarpal was done using 1.5-mm K-wires. The transverse flexor retinaculum (TFR) in this case was avulsed.
Discussion The divergent trapezium-trapezoid joint with scaphoid fracture is not described in the literature yet. The authors implicate steering wheel injury pattern for such complex carpal fracture dislocations. CT scan is imperative to diagnose and plan treatment of such fracture morphology. Early fracture reduction and stabilization of carpal dislocations are essential for proper functioning of wrist.
Subjektive Konzepte von Radioaktivität
Authors: Müller S. P. , Beyer T. , Bockisch A. , Freudenberg L. S. 
Published: March 2018

ZusammenfassungZiel dieser Untersuchung ist es, mit kulturwissenschaftlicher Methodik die Einstellungen zu radioaktiver Strahlung bei Patienten mit funktionell relevanter Schilddrüsenerkrankung vor und nach Radioiodtherapie zu untersuchen. Diese Studie überprüft, ob und inwieweit sich die Patientenbewertung von Radioaktivität als allgemeines Abstraktum und Radioaktivität im medizinischen Kontext ändert. Patienten, Methoden: 29 Patienten (17 Frauen, 12 Männer,Alter 35–79 Jahre) mit funktionell re-levanter Schilddrüsenautonomie wurden vor und 22–27 Monate nach Radioiodtherapie mit einer kombinierten qualitativen Technik (offene Interviews) und einem quantitativen Ranking (1: positiv bis 5: negativ) zu ihrer Einstellung gegenüber Radioaktivität im All-gemeinen und zur Radioiodtherapie im Besonderen befragt. Ergebnisse: Die inhaltsanalytische Auswertung zeigt ein heterogenes Bild von im Kern meist negativen Vorstellungen und Einschätzungen zur Radioaktivität im Allgemeinen, die im Wesentlichen vor und nach Radioiodtherapie nahezu unverändert sind. Dies bestätigt die quantitative Untersuchung,die keine signifikanten Unterschiede zeigt (p=0,15). Bezogen auf die therapeutische Anwendung von Radioaktivität geben die Patienten nach erfolgter Radioiodtherapie eine deutlich positivere Einschätzung.Auch in der qualitativen Auswertung zeigte sich eine signifikante Verbesserung der Einschätzung nach Radioiodtherapie (p=0,03). Schlussfolgerung: Eine erfolgreiche Radioiodtherapie ändert zwar die Einstellung zur Therapie selber – Radioaktivität imAllgemeinen wird aber weiter sehr negativ gesehen. Die Unter-suchungsergebnisse geben wichtige Informationen für das ärztliche Aufklärungsgespräch vor Radioiodtherapie,zum einen was den Um-gang mit Patientenaussagen und zum anderen was die Entwicklung von Strategien zum persönlichen Umgang damit angeht.
Giant Cell Tumor of the Capitate Bone
Authors: Afshar Ahmadreza , Tabrizi Ali , Aidenlou Ali , Abbasi Ata 
Published: March 2018

AbstractThis case report describes a 16-year-old female patient with a giant cell tumor in her right capitate bone. The tumor was removed by intralesional curettage. A high-speed burr was used to extend the margins of the curettage, and alcohol irrigation was used for adjuvant therapy. The cavity of the capitate was filled with allogenic bone graft. There was no recurrence after 2 years of follow-up, and the right wrist radiographs demonstrated healing of the lesion.
In Vitro and in Vivo Comparison of Binding of 99m-Tc-Iabeled Anti-CEA MAb F33-104 with 99m-Tc-labeled Anti-CEA MAb BW431/26
Authors: Oriuchi N. , Sugiyama S. , Kuroki M. , Matsuoka Y. , Tanada S. , Murata H. , Inoue T. , Sasaki Y. , Watanabe N. 
Published: March 2018

Summary
Aim: The purpose of this study was to assess the potential for radioimmunodetection (RAID) of murine anti-carcinoembryonic antigen (CEA) monoclonal antibody (MAb) F33-104 labeled with technetium-99m (99m-Tc) by a reduction-mediated labeling method. Methods: The binding capacity of 99m-Tc-labeled anti-CEA MAb F33-104 with CEA by means of in vitro procedures such as immunoradiometric assay and cell binding assay and the biodistribution of 99m-Tc-labeled anti-CEA MAb F33-104 in normal nude mice and nude mice bearing human colon adenocarcinoma LS180 tumor were investigated and compared with 99m-Tc-labeled anti-CEA MAb BW431/26. Results: The in vitro binding rate of 99m-Tc-labeled anti-CEA MAb F33-104 with CEA in solution and attached to the cell membrane was significantly higher than 99m-Tclabeled anti-CEA MAb BW431/261 (31.4 ± 0.95% vs. 11.9 ± 0.55% at 100 ng/mL of soluble CEA, 83.5 ± 2.84% vs. 54.0 ± 2.54% at 107 of LS 180 cells). In vivo, accumulation of 99m-Tc-labeled anti-CEA MAb F33-104 was higher at 18 h postinjection than 99m-Tc-labeled anti-CEA MAb BW431/26 (20.1 ± 3.50% ID/g vs. 14.4 ± 3.30% ID/g). 99m-Tcactivity in the kidneys of nude mice bearing tumor was higher at 18 h postinjection than at 3 h (12.8 ± 2.10% ID/g vs. 8.01 ± 2.40% ID/g of 99m-Tc-labeled anti-CEA MAb F33-104, 10.7 ± 1.70% ID/g vs. 8.10 ± 1.75% ID/g of 99m-Tc-labeled anti-CEA MAb BW431/26). Conclusion: 99m-Tc-labeled anti-CEA MAb F33-104 is a potential novel agent for RAID of recurrent colorectal cancer.
Costs of F-18-FDG PET with a Satellite Concept: Update
Authors: Schober O. , Lottes G. 
Published: March 2018

Summary
Aim: In an earlier study (study I) we had calculated the costs for FDG-PET investigations with our satellite concept (19). 433 patients were included in the study. Compared to the general indications for PET examinations the proportions of investigations were somewhat untypical: Both parameters have changed actually. Therefore we carried out a renewed data analysis (study II). Methods: All economic parameters were kept, in order to ensure the comparability of both studies. Only an adjustment of the costs to actual conditions was performed. Results: Proportions of investigations: Oncology 63%, Neurology 28%, Cardiology 9%; 3.5 investigations per working day. According to the increased number of investigations the structure of the total costs (DM 1601831) shows a small rise of the percentage costs for the FDG (41% to 42%) and a percentage decrease of the fixed overheads (48% to 43%). The percentage of personnel costs has increased (11% to 15%), the average cost per investigation has diminished: They amounted to DM 2783 in the earlier study (ranging from DM 2458 to 3463). The new data analy-sis results in the average cost of DM 2366 (-15%) per investigation (ranging from DM 2114 to 2840). Exemplary calculations show that a minimum of the costs will be achieved, if four investigations per day are performed. Retaining all parameters, which do not refer to the costs of the FDG, the average amount for one investigation would vary from DM 2000 (no delivery time) to DM 3300 (4 hours of delivery time). Conclusions: The results are in good agreement to the general laws of economic science, according to which an increase of the “number of units” with the same fixed overheads will result in a relative reduction of the costs of the “products”. A further increase in the frequency of investigations will lead to a rise of the average costs per investigation, because of the physical decay of the FDG delivered once a day.
Investigations on skeletal growth zones via bone scans as base of determination of optimal time for surgery in mandibular asymmetry
Authors: Werz R. , Reuland P. 
Published: March 2018

Summary
Aim of the study was to find out wether there is a common stop of growth of mandibular bone, so that no individual determination of the optimal time for surgery in patients with asymmetric mandibular bone growth is needed. As there are no epiphyseal plates in the mandibular bone, stop of growth cannot be determined on X-ray films. Methods: Bone scans of 731 patients [687 patients (324 male, 363 female) under 39 y for exact determination of end of growth and 44 (21 male, 23 female) patients over 40 y for evaluation of nongrowth dependant differences in tracer uptake] were reviewed for the study. All the patients were examined 3 hours after injection of 99mTc-DPD. Tracer uptake was measured by region of interest technique in different points of the mandibular bone and in several epiphyseal plates of extremities. Results: Tracer uptake in different epiphyseal plates of the extremities shows strong variation with age and good correlation with reported data of bone growth and closure of the epiphyseal plates. The relative maximum of bone activity is smaller in mandibular bone than in epiphyseal plates, which show well defined peaks, ending at 15-18 years in females and at 18-21 years in males. In contrast, mandibular bone shows no well defined end of growing but a gradually reduction of bone activity which remains higher than bone activity in epiphyseal plates over several years. Conclusion: No well defined end of growth of mandibular bone exists. The optimal age for surgery of asymmetric mandibular bone growth is not before the middle of the third decade of life, bone scans performed earlier for determination of bone growth can be omitted. Bone scans performed at the middle of the third decade of life help to optimize the time of surgical intervention.
Clinical applications of single photon emission tomography in neuromedicine
Authors: Grünwald F. , Kuwert T. , Tatsch K. , Sabri O. , Benkert O. , Fahlbusch R. , Gründer G. , Herzholz K. , Weiller C. , Bartenstein P. 
Published: March 2018

SummarySingle photon emission tomography is, because of its availability and the relatively low costs, the functional imaging modality currently most widely used for clinical applications in the brain. Beside the application of radiopharmaceuticals for the assessment of regional cerebral blood flow there is an increasing clinical use of more selective SPECT-radiopharmaceuticals, like amino acid analogs or receptor ligands. This article gives in his first part a critical review of the clinical applications of SPECT in neuro-oncology, epilepsy, basal ganglia disorders and cerebrovascular disease.
Direct comparison of F-l 8-FDG PET and ultrasound in the follow-up of patients with squamous cell cancer of the head and neck
Authors: Haenggeli C. A. , Allaoua M. , Albrecht S. R. , Dulguerov P. , Becker M. , Allai A. S. , Lehmann W. , Slosman D. O. , Goerres G. W. 
Published: March 2018

Summary
Aim: The objective of this study was to compare screening ultrasound (US) obtained in patients with squamous cell carcinoma of the head and neck with F-l 8-FDG PET and to evaluate if US obtained before F-l 8-FDG PFT has the potential to enhance patient management by the detection of additional lesions. Method: 28 patients were prospectively included in the study (7 females and 21 males; range: 28-82 years). All had one follow-up examination after surgical treatment and/or radiotherapy using a combination of US and F-l 8-FDG PET on the same day (6-35 months after the end of treatment). Outcome was determined by either biopsyproven cancer recurrence or negative clinical follow-up for additional 6 months after this examination. Results: Regarding only the regions of the neck evaluated with both methods, US detected 25 suspect lesions vs. 9 lesions detected by F-l 8-FDG PET. Descriptive statistical analysis showed better sensitivity, specificity and accuracy of F-l 8-FDG PET. Only in 3 patients a lesion was detected in the same anatomical region using both methods. One patient was false positive with both methods. In another patient US detected a calcified right carotid artery plaque that lead to surgical therapy. Conclusion: F-l 8-FDG PET is better for the detection of clinically relevant lesions in the follow-up of patients with squamous cell carcinoma of the head and neck. In this study, the additional value of morphological information obtained by screening US performed before the PET scan is limited. US may not be a suitable test to improve interpretation of PET examinations.
Hirn-SPECT mit 123J-markiertem Iodobenzamid (IBZM): Aspekte der semiquantitativen Auswertung
Authors: Grünwald F. , Klemm E. , Broich K. , Kasper S. , Reichmann K. , Hotze A. L. , Biersack H. J. , Menzel C. 
Published: March 2018

ZusammenfassungDie striatale Dopamin-D2-Rezeptoranreicherung von 123J-IBZM wurde bei 32 Patienten (18 ohne und 14 mit neuroleptischer Therapie) semiquantitativ unter Anwendung verschiedener ROI-Techniken ausgewertet. Ziel der Studie war es, die von verschiedenen Untersuchern gefundenen unterschiedlichen Quotienten (Striatum/Kortex) unter dem Aspekt der angewandten ROI-Technik zu untersuchen. Es konnte gezeigt werden, daß bei Verwendung des gleichen SPECT-Systems keine größeren Unterschiede zwischen Rechteck-ROI und manuell erstellten ROI gleicher Größe auftreten. Eine hochsignifikante Trennung zwischen behandelten und unbehandelten Patienten ergab sich für alle untersuchten Auswerteverfahren. Der ermittelte Quotient wird wesentlich durch das Auflösungsvermögen der Kamera und nur relativ geringfügig durch die verwendete ROI-Technik bestimmt. Die Quotienten verschiedener Arbeitsgruppen sind quantitativ nicht miteinander vergleichbar.
Pathogenetische Differenzierung des Skelettsuperscans mittels Knochenmarkszintigraphie
Authors: Müller-Mattheis V. G. O. , Vosberg H. , Müller-Gärtner H. W. , Weckesser M. 
Published: March 2018

ZusammenfassungDie Beobachtung eines 54jährigen Patienten mit Prostatakarzinom wird beschrieben, bei dem eine bei Diagnosestellung bereits vorliegende multifokale Skelettmetastasierung unter Androgendeprivation zunächst gebessert wurde. Nach drei Jahren klagte der Patient über zunehmende Knochenschmerzen insbesondere in den Kniegelenken. Es zeigte sich szintigraphisch eine Skelettdarstellung als »Superscan«, mit allerdings ungewöhnlicher Betonung des peripheren Skelettes der Arme und Beine. Die Knochenmarkszintigraphie zeigte eine disseminierte Skelettmetastasierung mit vollständiger Verdrängung des zentralen Knochenmarks und erheblicher Eröffnung peripherer Knochenmarksräume als Ursache für den skelettszintigraphischen Befund.
Arthroscintigraphy in Suspected Rotator Cuff Rupture
Authors: Gratz S. , Köster G. , Behr T. , Vosshenrich R. , Grabbe E. , Becker W. 
Published: March 2018

Summary
Aim: In order to evaluate the diagnostic efficiency of arthroscintigraphy in suspected rotator cuff ruptures this new imaging procedure was performed 20 times in 17 patients with clinical signs of a rotator cuff lesion. The scintigraphic results were compared with sonography (n = 20), contrast arthrography (n = 20) and arthroscopy (n = 10) of the shoulder joint. Methods: After performing a standard bone scintigraphy with intravenous application of 300 MBq 99m-Tc-methylene diphosphonate (MDP) for landmarking of the shoulder region arthroscintigraphy was performed after an intraarticular injection of 99m-Tc microcolloid (ALBURES 400 μCi/5 ml). The application was performed either in direct combination with contrast arthrography (n = 10) or ultrasound conducted mixed with a local anesthetic (n = 10). Findings at arthroscopical surgery (n = 10) were used as the gold standard. Results: In case of complete rotator cuff rupture (n = 5), arthroscintigraphy and radiographic arthrography were identical in 5/5. In one patient with advanced degenerative alterations of the shoulder joint radiographic arthrography incorrectly showed a complete rupture which was not seen by arthroscintigraphy and endoscopy. In 3 patients with incomplete rupture, 2/3 results were consistant. A difference was seen in one patient with a rotator cuff, that has been already revised in the past and that suffered of capsulitis and calcification. Conclusion: Arthroscintigraphy is a sensitive technique for detection of rotator cuff ruptures. Because of the lower viscosity of the active compound, small ruptures can be easily detected, offering additional value over radiographic arthrography and ultrasound, especially for evaluation of incomplete cuff ruptures.