bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Metode Mind Mapping untuk Meningkatkan Hasil Belajar dan Aktifitas Siswa
Authors: Asmaun Asmaun , Talib Ahmad , Rifandi Muh. 
Published: October 2024

Rendahnya hasil belajar dan aktifitas siswa di sekolah salah satunya akibat dari kurang bervareasinya metode yang diajarkan guru dalam pembelajaran dan siswa belum memiliki cara mencatat materi yang menarik dan efisien untuk memahami pelajaran. Penelitian yang digunakan merupakan penelitian tindakan kelas, berlangsung di kelas VII SMP Negeri 5 Majene. Maksud serta tujuan yang ingin dicapai pada penelitian adalah meningkatkan ketuntasan hasil belajar siswa dan aktifitas siswa dalam kegiatan pembelajaran dengan penerapan metode Mind Mapping. Terdapat sebanyak 22 siswa perempuan dan 12 siswa laki-laki dari total 34 siswa yang menjadi subjek penelitian. Data penelitian dianalisis secara deskriptif kualitatif dan kuantitatif. Hasil yang didapatkan bahwa terjadi kenaikan pada rata-rata hasil belajar individu siswa, yaitu pada siklus pertama sebesar 50,47 dengan ketuntasan klasikal 29% atau hanya 10 siswa dari 34 siswa yang mencapai standar kelulusan. Sementara pada siklus kedua terjadi peningkatan rata-rata hasil belajar menjadi 71,51 dengan ketuntasan klasikal sebesar 80%. Begitupula pada aktivitas siswa juga terjadi kenaikan skor rata-rata yaitu pada siklus pertama sebesar 2,31 dengan klasifikasi cukup serta di siklus kedua terjadi kenaikan pada nilai 3,32 dengan klasifikasi baik. Jadi kesimpulan yang didapatkan pada penelitian adalah dengan penggunaan metode Mind Mapping dalam kegiatan belajar mengajar bisa menambah nilai ketuntasan hasil belajar dan skor aktifitas siswa.
Klasifikasi Konsep Nama Suku Minangkabau: Tinjauan Antropologi Linguistik
Authors: Razin Thariq , N Nurhayati 
Published: October 2024

Penelitian ini bertujuan mengklasifikasikan konsep nama suku budaya masyarakat Minangkabau. Penelitian ini menggunakan pendekatan antropologi linguistik. Jenis penelitian ini deskriptif kualitatif. Sumber data berasal dari dokumen dan narasumber. Data berupa transkripsi wawancara dan dokumen. Metode pengumpulan data dalam penelitian ini menggunakan observasi, wawancara, dan dokumen. Data dianalisis secara reduksi, kategorisasi, dan sintesisasi. Data disajikan secara informal. Hasil penelitian ditemukan sembilan konsep yang indentik mewakili budaya Minangkabau dalam nama suku/pasukuan di dalam masyarakat. Temuan sembilan konsep ini saling memiliki keterkaitan antara cara pikir, budaya, dan bahasa. Klasifikasi sembilan konsep dalam nama suku berupa konsep bilangan, konsep fauna, konsep flora, konsep tempat, konsep buah-buahan, konsep arah, konsep sifat, konsep percabangan, dan konsep penggabungan. Budaya masyarakat Minangkabau memiliki pengamatan dan interpretasi yang tajam terhadap alam hingga membentuk konsensus budaya yang dapat diamati dalam pengayaan konsep nama dalam suku.
Decoding Users’ Continuance Intentions towards Digital Financial Platforms in the Indian Economy
Authors: Elangovan Anandhi , Babu Manivannan 
Published: October 2024

Indian financial sector has seen a dramatic change in recent years, with digital finance unlocking new possibilities for financial inclusion. This paper investigates the factors influencing the continuous usage intention and advocacy intention, regarding digital finance, in the Indian economy. Utilizing the Stimulus-Organism-Response (S-O-R) model, the study examines how ease of use, credibility and ubiquity (stimulus) could influence user trust, satisfaction, and engagement (organism), ultimately affecting their intention to use and recommend the service (response) continuously. Non-probability convenience sampling technique was used to select the study sample. Based on the results, features of digital financial platforms such as ease of use, credibility and ubiquity, were found to have a significant impact on user trust, satisfaction, and engagement. These factors partially mediate the stimulus and response variables. The research findings provide Digital Financial Service Providers (DFSPs) with practical guidance on creating and implementing user-centric platforms that create engagement and trust. User experience should be prioritized and making sure that platform should be accessible, easy to use and compatible with a variety of devices.
Tinjauan Yuridis terhadap Perbuatan Melawan Hukum Pembina Yayasan yang Melakukan Penyalahgunaan Wewenang dalam Pergantian Organ Yayasan
Authors: Balhmar Naflah Lukman , Purwanto Aldira Mara Ditta Caesar 
Published: October 2024

The replacement of Foundation Organs is carried out when the term of office of the foundation organ has expired and is not re-elected or when the foundation organ has committed acts deemed detrimental to the foundation by the foundation founder as conducted based on the foundation founder's meeting. If the foundation meeting is not held in accordance with quorum provisions stipulated in the Foundation Law and the Articles of Association, then the founder must be held responsible for his actions. This study was conducted using normative research methods. The results show that the unlawful act committed by the founder in the replacement of foundation organs is the abuse of authority by not adhering to the quorum provisions of the founder's meeting by 2/3 of the founder members, while the responsibility for the unlawful acts refers to civil liability in accordance by Article 1365 of the Civil Code. The legal consequences of such unlawful acts on the foundation organ include the occurrence of dualism in the management of the foundation, the invalidity of decisions made by the newly appointed organ which was unlawfully appointed, and damages to third parties.
Analisis Validitas Instrumen Lembar Kerja Peserta Didik Bermuatan Nilai-Nilai Islam Berbasis Problem Based Learning Pada Materi Himpunan Kelas VII
Authors: Rahmawati Novia , Iesyah Rodliyah  
Published: October 2024

Pendidikan merupakan sebuah kebutuhan yang utama bagi tiap manusia. Salah satu ilmu pengetahuan yang penting dalam kemajuan proses berfikir serta mampu menyelesaikan masalah didalam kehidupan sehari-hari adalah matematika. Masih banyak peserta didik dikalangan pesantren yang masih membeda-bedakan antara pelajaran agama dengan pelajaran umum khususnya matematika. Penelitian ini bertujuan untuk menghasilkan media pembelajaran berupa LKPD bermuatan nilai-nilai Islam berbasis masalah pembelajaran materi himpunan. Artikel ini adalah bagian dari penelitian besar pada pengembangan media pembelajaran dengan model ADDIE. Metode penelitian ini adalah Research and Development dengan model pengembangan ADDIE. Langkah yang dilakukan hanya tahap 1 sampai 3 yaitu analisis, perancangan dan pengembangan. Hasil validasi dari dosen memperoleh hasil rata-rata 83,3% dengan kriteria sangat valid dan hasil validasi dari guru mendapatkan hasil rata-rata 82,5% dengan kriteria sangat valid. Hasil rata-rata validasi dari kedua validator adalah 82,9% dengan kriteria sangat valid.
Pathogen spectrum and microbiome in lower respiratory tract of patients with different pulmonary diseases based on metagenomic next-generation sequencing
Authors: Hong Rujun , Lin Sheng , Zhang Siting , Yi Yaxing , Li Lanfeng , Yang Haitao , Du Zhenshan , Cao Xuefang , Wu Wenjie , Ren Ruotong , Yao Xiujuan , Xie Baosong 
Published: October 2024

IntroductionThe homeostasis of the microbiome in lower respiratory tract is crucial in sustaining normal physiological functions of the lung. Different pulmonary diseases display varying degrees of microbiome imbalance; however, the specific variability and clinical significance of their microbiomes remain largely unexplored.MethodsIn this study, we delineated the pathogen spectrum and commensal microorganisms in the lower respiratory tract of various pulmonary diseases using metagenomic sequencing. We analyzed the disparities and commonalities of the microbial features and examined their correlation with disease characteristics.ResultsWe observed distinct pathogen profiles and a diversity in lower airway microbiome in patients diagnosed with cancer, interstitial lung disease, bronchiectasis, common pneumonia, Nontuberculous mycobacteria (NTM) pneumonia, and severe pneumonia.DiscussionThis study illustrates the utility of Metagenomic Next-generation Sequencing (mNGS) in identifying pathogens and analyzing the lower respiratory microbiome, which is important for understanding the microbiological aspect of pulmonary diseases and essential for their early and precise diagnosis.
Future directions for deep ocean climate science and evidence-based decision making
Authors: Pillar Helen R. , Hetherington Elizabeth , Levin Lisa A. , Cimoli Laura , Lauderdale Jonathan M. , van der Grient Jesse M. A. , Johannes Kristen , Heimbach Patrick , Smith Leslie , Addey Charles I. , Annasawmy Pavanee , Antonio Sandra , Bax Narissa , Drake Henri F. , Escobar Elva , Elsler Laura G. , Freilich Mara A. , Gallo Natalya D. , Girard Fanny , Harke Matthew J. , Jones Daniel O. B. , Joshi Siddhi , Liang Xinfeng , Maroni Paige J. , Sarti Otmane , Stefanoudis Paris V. , Sulpis Olivier , Trossman David 
Published: October 2024

IntroductionA defining aspect of the Intergovernmental Panel on Climate Change (IPCC) assessment reports (AR) is a formal uncertainty language framework that emphasizes higher certainty issues across the reports, especially in the executive summaries and short summaries for policymakers. As a result, potentially significant risks involving understudied components of the climate system are shielded from view.MethodsHere we seek to address this in the latest, sixth assessment report (AR6) for one such component—the deep ocean—by summarizing major uncertainties (based on discussions of low confidence issues or gaps) regarding its role in our changing climate system. The goal is to identify key research priorities to improve IPCC confidence levels in deep ocean systems and facilitate the dissemination of IPCC results regarding potentially high impact deep ocean processes to decision-makers. This will accelerate improvement of global climate projections and aid in informing efforts to mitigate climate change impacts. An analysis of 3,000 pages across the six selected AR6 reports revealed 219 major science gaps related to the deep ocean. These were categorized by climate stressor and nature of impacts.ResultsHalf of these are biological science gaps, primarily surrounding our understanding of changes in ocean ecosystems, fisheries, and primary productivity. The remaining science gaps are related to uncertainties in the physical (32%) and biogeochemical (15%) ocean states and processes. Model deficiencies are the leading cited cause of low certainty in the physical ocean and ice states, whereas causes of biological uncertainties are most often attributed to limited studies and observations or conflicting results.DiscussionKey areas for coordinated effort within the deep ocean observing and modeling community have emerged, which will improve confidence in the deep ocean state and its ongoing changes for the next assessment report. This list of key “known unknowns” includes meridional overturning circulation, ocean deoxygenation and acidification, primary production, food supply and the ocean carbon cycle, climate change impacts on ocean ecosystems and fisheries, and ocean-based climate interventions. From these findings, we offer recommendations for AR7 to avoid omitting low confidence-high risk changes in the climate system.
Investigating the metabolomic pathways in female reproductive endocrine disorders: a Mendelian randomization study
Authors: Lu Fei-fan , Wang Zheng , Yang Qian-qian , Yan Feng-shang , Xu Chang , Wang Ming-tang , Xu Zhu-jing , Cai Sheng-yun , Guan Rui 
Published: October 2024

IntroductionReproductive endocrine disorders (RED), including polycystic ovary syndrome (PCOS), endometriosis (EMs), and female infertility (FI), significantly affect women’s health globally, with varying prevalence across different regions. These conditions can be addressed through medication, surgical interventions, and lifestyle modifications. However, the limited understanding of RED’s etiology and the substantial economic burden of its treatment highlight the importance of investigating its pathogenesis. Metabolites play a critical role in metabolic processes and are potentially linked to the development of RED. Despite existing studies suggesting correlations between metabolites and RED, conclusive evidence remains scarce, primarily due to the observational nature of these studies, which are prone to confounding factors.MethodsThis study utilized Mendelian Randomization (MR) to explore the causal relationship between metabolites and RED, leveraging genetic variants associated with metabolite levels as instrumental variables to minimize confounding and reverse causality. Data were obtained from the Metabolomics GWAS Server and the IEU OpenGWAS project. Instrumental variables were selected based on their association with the human gut microbiota composition, and the GWAS summary statistics for metabolites, PCOS, EMs, and FI were analyzed. The MR-Egger regression and random-effects inverse-variance weighted (IVW) methods were employed to validate the causal relationship. Cochran’s Q test was employed to evaluate heterogeneity, sensitivity analysis was performed using leave-one-out analysis, and for pleiotropy analysis, the intercept term of MR-Egger’s method was investigated.ResultsThe MR analysis revealed significant associations between various metabolites and RED conditions. For instance, a positive association was found between 1-palmitoylglycerophosphocholine and PCOS, while a negative association was noted between phenylacetate and FI. The study identified several metabolites associated with an increased risk and others with protective effects against PCOS, EMs, and FI. These findings highlight the complex interplay between metabolites and RED, suggesting potential pathways through which these conditions could be influenced or treated.ConclusionThis MR study provides valuable insights into the causal relationship between metabolites and female reproductive endocrine disorders, suggesting that metabolic alterations play a significant role in the pathogenesis of PCOS, EMs, and FI, and offering a foundation for future research and therapeutic development.
Clinical features of pituitary carcinoma: analysis based on a case report and literature review
Authors: Yang Yongxiang , Liang Wanlin , Fan Kexia , Yang Tao , Cheng Jingmin 
Published: October 2024

IntroductionPituitary carcinoma (PC) is an extremely rare tumor of the adenohypophysis, which manifests as craniospinal dissemination and/or systemic metastasis. The diagnosis of PC is particularly difficult, as the clinical diagnosis only can be made after the metastasis is found. Owing to the complex diagnostic process and less effective treatments, the clinical prognosis of PC is usually very poor. Hence, it is of great significance to illustrate the diagnosis and treatment course of PC.MethodsIn this case report, we described a 48-year-old male patient who was diagnosed with pituitary adenoma (PA) initially and then was diagnosed with PC eventually after spinal cord metastasis was found, and we illustrated the treatment course as well. Furthermore, we summarized all the published case reports until now and provided a comprehensive review of the diagnosis, treatment, prediction, and clinical outcome of PC.Results and ConclusionsWe found that most PC patients had adrenocorticotropic hormone/prolactin (ACTH/PRL)-secreting tumors, Ki-67 ≥ 10%, and P53 positivity, which may have the potential to predict the transformation from PA to PC; surgery excision combined with temozolomide (TMZ) and radiotherapy is helpful to prolong the survival of PC patients.
MMP-9 as a clinical marker for endometriosis: a meta-analysis and bioinformatics analysis
Authors: Huang Qiumei , Song Yanlun , Lei Xiaocan , Huang Hua , Nong Weihua 
Published: October 2024

AimThis study systematically evaluated the potential efficacy of serum matrix metalloproteinase-9 (MMP-9) concentration as a diagnostic marker for endometriosis through meta-analysis. Early and accurate diagnosis of endometriosis, a common gynecological disease, is crucial for improving patient prognosis. Hence, this study aimed to comprehensively analyze the data from multiple studies to assess the diagnostic value of serum MMP-9 concentration for endometriosis.MethodsArticles investigating the association between MMP-9 and endometriosis, published from the inception of the databases until February 2024, were systematically retrieved from multiple databases, including PubMed, Embase, Cochrane, Web of Science, Scopus, and CNKI. Download and analyze the GSE7305, GSE23339, and GSE51981 datasets. Statistical analyses of all eligible studies were conducted using RevMan 5.4, Stata 11.0, and R software version 4.3.3.ResultsFifteen studies fully met the inclusion criteria for the meta-analysis. The concentration of MMP-9 in the blood of patients with endometriosis was significantly higher compared to that of the control group (p &lt; 0.0001). Subgroup analysis based on different stages of endometriosis revealed a trend towards significantly higher serum MMP-9 concentrations in patients, whether in stages I-II or III-IV. Bioinformatics analysis revealed differences in the expression of MMP-9 in endometrial tissue between EMT patients and healthy controls in the GSE7305 and GSE23339 datasets. Additionally, in the GSE51981 dataset, we found significant differences between the normal group and both mild and severe cases of endometriosis.ConclusionBoth the current meta-analysis and bioinformatics analysis indicate differences in MMP-9 concentration levels between endometriosis patients and healthy individuals, with potentially elevated MMP-9 concentrations in serum samples from patients with endometriosis.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42024525864.
Exome sequencing data reanalysis of 200 hypertrophic cardiomyopathy patients: the HYPERGEN French cohort 5 years after the initial analysis
Authors: Jaouadi Hager , Morel Victor , Martel Helene , Lindenbaum Pierre , de la Chapelle Lorcan Lamy , Herbane Marine , Lucas Claire , Magdinier Frédérique , Gilbert Habib , Schott Jean-Jacques , Zaffran Stéphane , Nguyen Karine 
Published: October 2024

BackgroundApproximately half of hypertrophic cardiomyopathy (HCM) patients lack a precise genetic diagnosis. The likelihood of identifying clinically relevant variants increased over time.MethodsIn this study, we conducted a gene-centric reanalysis of exome data of 200 HCM cases 5 years after the initial analysis. This reanalysis prioritized genes with a matched HCM entry in the OMIM database and recently emerging HCM-associated genes gathered using a text mining-based literature review. Further classification of the identified genes and variants was performed using the Clinical Genome Resource (ClinGen) resource and American College of Medical Genetics and Genomics (ACMG) guidelines to assess the robustness of gene–disease association and the clinical actionability of the prioritized variants.ResultsAs expected, the majority of patients carried variants in MYBPC3 and MYH7 genes, 26% (n = 51) and 8% (n = 16), respectively, in accordance with the initial analysis. The vast majority of pathogenic (P) and likely pathogenic (LP) variants were found in MYBPC3 (22 out of 40 variants) and MYH7 (8 out of 16 variants) genes. Three genes—not included in the initial analysis—were identified: SVIL, FHOD3, and TRIM63. Considering only patients with unique variants in the last three genes, there was a 9% enhancement in variant identification. Importantly, SVIL variant carriers presented apical and septal HCM, aortopathies, and severe scoliosis for one patient. Ten patients (5%) carried variants in the FHOD3 gene, six in hotspot regions (exons 12 and 15). We identified seven variants within the TRIM63 gene in 12 patients (6%). Homozygous variants were detected in 2.5% of the cohort in MYBPC3 (n = 1), MYL3 (n = 1), and TRIM63 (n = 3) genes.ConclusionOur study revealed that no variants were found in the ACTC1, TPM1, and TNNI3 genes in the HYPERGEN cohort. However, we identified variants in five out of the eight HCM core genes, with a high prevalence in young patients. We identified variants in three recent HCM-associated genes (SVIL, FHOD3, and TRIM63) in 35 patients, with 18 patients carrying unique variants (9%). Our results further emphasize the usefulness of exome data reanalysis, particularly in genotype-negative patients.
Caregivers in implantable brain-computer interface research: a scoping review
Authors: Wohns Nicolai , Dorfman Natalie , Klein Eran 
Published: October 2024

IntroductionWhile the ethical significance of caregivers in neurological research has increasingly been recognized, the role of caregivers in brain-computer interface (BCI) research has received relatively less attention.ObjectivesThis report investigates the extent to which caregivers are mentioned in publications describing implantable BCI (iBCI) research for individuals with motor dysfunction, communication impairment, and blindness.MethodsThe scoping review was conducted in June 2024 using the PubMed and Web of Science bibliographic databases. The articles were systematically searched using query terms for caregivers, family members, and guardians, and the results were quantitatively and qualitatively analyzed.ResultsOur search yielded 315 unique studies, 78 of which were included in this scoping review. Thirty-four (43.6%) of the 78 articles mentioned the study participant’s caregivers. We sorted these into 5 categories: Twenty-two (64.7%) of the 34 articles thanked caregivers in the acknowledgement section, 6 (17.6%) articles described the caregiver’s role with regard to the consent process, 12 (35.3%) described the caregiver’s role in the technical maintenance and upkeep of the BCI system or in other procedural aspects of the study, 9 (26.5%) discussed how the BCI enhanced participant communication and goal-directed behavior with the help of a caregiver, and 3 (8.8%) articles included general comments that did not fit into the other categories but still related to the importance of caregivers in the lives of the research participants.DiscussionCaregivers were mentioned in less than half of BCI studies in this review. The studies that offered more robust discussions of caregivers provide valuable insight into the integral role that caregivers play in supporting the study participants and the research process. Attention to the role of caregivers in successful BCI research studies can help guide the responsible development of future BCI study protocols.