bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement of cooked rice stickiness with consideration of contact area in compression test
Authors: Yang Jung Hwa , Park Han Jo , Jang Han Dong , Lee Seung Ju 
Published: September 2018

AbstractThe cooked rice stickiness is conventionally measured as the maximum detachment force required to separate the probe from the sample, after compression on the platform of a texture analyzer. A corrected stickiness (the measured stickiness force divided by the contact area) was newly created to avoid the deviation of stickiness influenced by the contact area varying with the rice sample's irregularity, regarding shape and size. The contact area could be estimated from the volume, density, and thickness of the samples. The compression force triggering the stickiness was also converted to the corrected compression force (the force divided by the contact area). Two varieties of rice (short‐grain rice and glutinous rice) were cooked with different amount of water to prepare the samples with various stickiness levels. The contact area was mostly higher in the glutinous rice than short‐grain rice. The contact area increased with the cooking water amount. Three parameters were compared such as the stickiness (the measured force), the primarily corrected stickiness (the corrected stickiness at a fixed value of compression force), and the secondarily corrected stickiness (the corrected stickiness at a fixed value of the corrected compression force). The difference between the rice samples was the most pronounced in the secondarily corrected stickiness. The correlation between the instrumental and sensorial stickiness was also the highest in the secondarily corrected stickiness. Conclusively, the new corrected parameters enhanced the sample discrimination capability and the agreement with the sensorial stickiness than the uncorrected stickiness.Practical applicationsStickiness is the important quality factor associated with cooked rice preferences. Instrumental stickiness is a detaching force of the preliminarily compressed rice grain by cylindrical probe of texture testing equipment. When it comes to a force measurement, the contact area is usually considered to convert the force to stress. But, for the samples like cooked rice grain, with smaller contact area than that of probe, the contact area is not easy to know because it is not simply the probe bottom area. So the contact area had not been employed to measure cooked rice stickiness. In this study, an established method was devised to figure out the contact area. The corrected stickiness by considering the contact area proved to be more accurate than the original stickiness through sensory evaluation.
Northerners and Southerners Differ in Conflict Culture
Authors: Van de Vliert Evert , Conway Lucian Gideon 
Published: September 2018

AbstractThe present study uses regression analysis of existing cross‐national data sets to demonstrate that ingroup–outgroup discrimination and intergroup conflict management vary more along the north–south (latitudinal) axis than along the east–west axis of the Earth. Ingroup favoritism, outgroup rejection, political oppression, legal discrimination, and communication bullying are all less prevalent among Northerners than among Southerners in the Northern Hemisphere, but more prevalent among Northerners than among Southerners in the Southern Hemisphere. These findings provide a rich source for further research into how social conflicts are habitually experienced and handled by residents of northern versus southern habitats. A supplementary analysis specifies the extent to which ecological stressors—thermal stress, hydraulic stress, pathogenic stress, and subsistence stress—help explain why there are oppositely sloping north–south gradients of conflict culture above and below the equator. Taken in total, these results demonstrate the importance of considering latitude in forming a deeper understanding of conflict management and negotiation.
Systematic review of rituximab for autoimmune diseases: a potential alternative to intravenous immune globulin
Authors: MacIsaac John , Siddiqui Reda , Jamula Erin , Li Na , Baker Steven , Webert Kathryn E. , Evanovitch Denise , Heddle Nancy M. , Arnold Donald M. 
Published: September 2018

BACKGROUNDThe anti‐CD20 monoclonal antibody rituximab has immune‐modulatory effects similar to intravenous immunoglobulin (IVIG). We performed a systematic review and meta‐analysis to determine the efficacy and safety of rituximab in autoimmune diseases that are also treated with IVIG.STUDY DESIGN AND METHODSThe most common indications for immune modulation with IVIG, as identified from a 2012 regional audit in Canada, were chronic inflammatory demyelinating polyneuropathy (CIDP), immune thrombocytopenia (ITP), myasthenia gravis, multifocal motor neuropathy, Guillain‐Barré syndrome, systemic lupus erythematosus (SLE), Sjogren's syndrome, and pemphigus vulgaris. We searched MEDLINE, EMBASE, and the Cochrane Library until July 2016 for studies evaluating rituximab in each of these conditions. The primary outcome in our meta‐analysis was clinical response at 6 months as defined by disease‐specific criteria in randomized trials. We also calculated pooled proportions of responders within disease types from observational studies.RESULTSNinety‐five rituximab studies were identified: 86 were observational studies in patients with ITP (n = 1746), SLE (n = 1047), pemphigus vulgaris (n = 564), Sjogren's syndrome (n = 138), myasthenia gravis (n = 66), and CIDP (n = 31) and nine were randomized controlled trials (n = 992) in patients with ITP, SLE, and Sjogren's syndrome that compared rituximab with placebo plus standard of care. Among randomized trials, response rates were higher with rituximab (relative risk, 1.38; 95% confidence interval [CI], 1.05‐1.83). The pooled proportion of rituximab responses ranged from 94% (95% CI, 88%‐98%) for pemphigus vulgaris to 48% (95% CI, 30%‐66%) for CIDP. Rituximab was generally well tolerated in observational studies although in the randomized trials, adverse events were more common in the rituximab group.CONCLUSIONRituximab is an immune‐modulating agent with biologic activity across many autoimmune conditions. Our data support the use of comparative trials with broad eligibility criteria to evaluate rituximab as an alternative to IVIG in autoimmune diseases.
Evaluating Algibon adsorbent and adsorption kinetics for launderette water treatment: towards sustainable water management
Authors: Tony Maha A. , Parker Helen L. , Clark James H. 
Published: September 2018

AbstractGrey water from commercial laundry facility was used for treatment to substitute the conventional water sources. Algibon, A800 derived from mesoporous alginic acid and Starbon S300, carbonaceous mesoporous polysaccharide‐derived materials, silica gel (SG) and activated carbon (AC) were used for the treatment of wastewater. The optimum adsorbent dosing and pH value for each adsorption system are defined. The adsorption efficiency are in the order of A800 > SG > AC > S300 and the removal rate reached to 91% when A800 was used. Furthermore, the reaction followed the second‐order kinetic model and the rate constant is high when A800 adsorbent is applied.
Ointment vehicles regulate the wound‐healing process by modifying the hyaluronan‐rich matrix
Authors: Murasawa Yusuke , Furuta Katsunori , Noda Yasuhiro , Nakamura Hiroyuki , Fujii Satoshi , Isogai Zenzo 
Published: September 2018

AbstractTopical ointment consists of an active ingredient and vehicle, and the vehicle largely comprises the volume of the ointment. During the treatment of chronic wounds, such as pressure ulcers, the vehicle has been considered inactive, only serving as a carrier of the main pharmaceutical. However, recent reports have indicated that the vehicle has distinct clinical effects that depend on its physicochemical properties. Therefore, an understanding of the action mechanism of the ointment vehicle in wound tissue is necessary. In this study, we established a mouse model to analyze tissue reactions induced by the following ointment vehicles, an oil‐in‐water emulsion (EM) vehicle; a macrogol ointment (MO), which is a water‐soluble, hydrophilic vehicle; and a MOs containing sucrose (MS). EM‐treated wounds exhibited an inflammatory reaction characterized by tissue edema and thick granulation tissue; however, MO‐ and MS‐treated wounds did not exhibit this reaction. Moreover, EM‐treated wounds exhibited infiltration of inflammatory cells unlike MO‐treated wounds. In contrast, the formation of collagenous tissue was dominantly observed in MO‐treated wounds. Because the vehicle regulates the water environment of the wound, the water‐holding extracellular matrix molecules, including hyaluronan (HA) and proteoglycan, were examined using immunohistochemical and biochemical methods. The versican G1 fragment, serum‐derived HA‐associated protein (SHAP) and HA (the VG1F‐SHAP‐HA) complex characteristically found in inflammatory conditions of pressure ulcers was found in EM‐treated wounds. To histologically analyze the mechanism of action of the vehicle, we evaluated the ointment vehicle‐wound tissue interface in an en bloc manner. Formation of the HA‐containing complex was observed locally between the vehicle and wound surface. On the basis of these data, ointment vehicles regulate the wound‐healing process through the formation of HA‐rich extracellular matrices at the ointment‐wound interface. This study provides a better understanding of the treatment of deep‐pressure ulcers with focus on ointment vehicles.
Adaptability of Next Generation Hull-Platform “Noah-FPSO Hull”
Authors: Tanaka Shigeru , Takano Kotaro , Sogawa Yasuhiro , Nakamura Ken , Inoue Tadashi , Mori Masaharu , Otonari Mikito 
Published: September 2018

In general, petroleum reservoirs vary with geographical locations and their environmental conditions, and there are no crude and gas exactly alike in respective locations. This means that it is very difficult to apply a specific standard design, which is usually preferred by many shipyards, to any FPSO hull.
These facts often lead to serious trouble for FPSO hull construction in terms of cost and delivery time.
In order to solve those challenging issues, Mitsui E&S Shipbuilding Co., Ltd. developed a next generation FPSO platform, “noah-FPSO Hull” (noah : New Offshore Adapted Hull), and obtained Approval in Principle for the noah-FPSO Hull from two world leading classification societies, Bureau Veritas and American Bureau of Shipping.
Unique modular design and multi-yard construction concept of the noah-FPSO Hull were overviewed and discussed in our 1st report [1]. This paper is the 2nd report of the noah-FPSO Hull and focuses on discussing specific modular design for structural design and equipment arrangement. Hull motion in adverse weather condition is also discussed.
Long-Term Analysis of Extreme Global Restoring Loads on a FPSO Turret Structure Using a Coupled Model
Authors: Puente Isabel Jimenez , Larsen Kjell 
Published: September 2018

A turret structure can be a major design driver for FPSO systems. Therefore, careful attention needs to be given to the estimation of extreme loads on this structural element.
This paper presents an all seas long-term analysis of the extreme global restoring forces acting on a FPSO turret structure, and a comparison with the results obtained through the contour line approach.
The analysis is performed in the time domain using a coupled model, where the floater is modelled in the software SIMO, and the risers and mooring lines are represented by a Finite Element Model in RIFLEX.
The characteristic responses of the turret structure with q-annual probability of exceedance are estimated from a full long-term analysis where both the short and long-term variability are considered. These results are compared to those obtained through the long-term estimate from the contour line approach when assuming 90th percentile for the worst sea state with q-annual probability of exceedance.
The results from the full long-term analysis will allow us to verify the adequate percentile level to be used with a contour line approach when estimating extreme turret structure loads.
Integrated Decommissioning of a Pentagon Shaped Production Semisubmersible in the UK: A Unique Challenge
Authors: Batalla Toro Luis F. , Reid Simon L. , Tudela Alfredo Salcines , Graham Duncan 
Published: September 2018

Between 1969 and 1977, eleven semisubmersible drilling platforms were designed and built with an innovative pentagon shaped hull, specifically to work in the harsh environment of the North Sea. One of the drilling rigs, the Alexander L. Kielland, was converted soon after construction into an accommodation platform (flotel) and failed catastrophically in 1980. Another, the Pentagon 83 “Drillmaster” (renamed as Buchan Alpha), was being converted to a Floating Production Unit at the time of the disaster. The structure of Buchan Alpha was significantly modified during the conversion of the platform so that it benefited from the lessons learnt following the Alexander L. Kielland accident to ensure that the same sequence of events could not be repeated.
This technical paper objective is to explain the integrated decommissioning process of the Buchan Alpha in the UK after more than 40 years since being built and more than 35 years of successful operation since it was converted to a Floating Production Unit, and how the features of its original design have accompanied the platform through the decommissioning process.
The scope covers all phases of Buchan Alpha decommissioning from the detailed planning and preparation, the suspension of production up to the dismantling and recycling process.
Significant challenges for the decommissioning team included the requirement to preserve the operational status of the subsea infrastructure for potential future field redevelopment and the diver disconnection of the subsea wells.
Buchan Alpha’s deep draught presented limitations on the selection of dismantling and recycling yards due to quayside water depths. Complex ballasting operations and removal of the thruster’s propellers were required to facilitate the platform berthing at the quayside.
Key lessons learned applicable for future decommissioning of floating production facilities will be shared.
Numerical Study on the Effect of a Submerged Breakwater Seaward of an Existing Breakwater for Climate Change Adaptation
Authors: Sasikumar Athul , Kamath Arun , Musch Onno , Erling Lothe Arne , Bihs Hans 
Published: September 2018

In coastal areas, climate change is causing mean sea level rise and more frequent storm surge events. This means the breakwaters are expected to withstand the action of more severe incident waves and larger overtopping rates than they were designed for. Therefore, these impacts may have a negative effect on the functionality such as overtopping above the acceptable limits, in addition to stability of these structures. A breakwater which has been partly damaged by a storm stronger than the design storm has weak spots that can easily be damaged further. One way of protecting these breakwaters subjected to climate change is to build a submerged breakwater on the seaward side.
This study focuses on the use of numerical model for optimal dimension of a submerged breakwater to be used as a protective measure for an existing structure. Comparisons are made between transmission coefficient predicted in the numerical model and those calculated from different formulae in literature. The variation in transmission coefficient due to different relative submergence and relative width parameters for waves with different steepness is studied and curves showing the dependence of these parameters on wave transmission are made. These results are then used for a test case in Kiberg, Norway where a submerged breakwater is proposed in front of a existing damaged rubble mound breakwater. The optimal geometry generated on the basis of curves is then implemented in the local-scale finite element wave prediction model, CGWAVE.
Hydrodynamic Coefficients of Simplified Subsea Structures
Authors: Mentzoni Fredrik , Abrahamsen-Prsic Mia , Kristiansen Trygve 
Published: September 2018

Simplified two-dimensional models, representing components of complex subsea structures, are experimentally investigated. Individual as well as combinations of components in different configurations are tested, in order to study the effect of hydrodynamic interaction. The components include porous plates and cylindrical pipes with circular cross-section. Hydrodynamic added mass and damping coefficients, relevant for force estimation during lifting operations, are presented. The coefficients are obtained based on forced oscillation tests for a large range of Keulegan–Carpenter (KC) numbers and forcing periods, and compared to numerical source panel results for the low KC limit, as well as recommendations given by DNV GL, where relevant.
Coefficients for all configurations are found to be highly amplitude dependent. Significant interaction effects are found for the assembled structures, causing either reduced or increased total added mass and damping coefficients compared to the super-position of the coefficients for individual members.
Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas
Authors: Unruh Dusten , Mirkov Snezana , Wray Brian , Drumm Michael , Lamano Jonathan , Li Yuping D. , Haider Qazi F. , Javier Rodrigo , McCortney Kathleen , Saratsis Amanda , Scholtens Denise M. , Sarkaria Jann N. , James C. David , Horbinski Craig 
Published: September 2018

Abstract

Purpose:
Gliomas with isocitrate dehydrogenase 1 mutations (IDH1mut) are less aggressive than IDH1 wild-type (IDH1wt) gliomas and have global genomic hypermethylation. Yet it is unclear how specific hypermethylation events contribute to the IDH1mut phenotype. Previously, we showed that the gene encoding the procoagulant tissue factor (TF), F3, is among the most hypermethylated and downregulated genes in IDH1mut gliomas, correlating with greatly reduced thrombosis in patients with IDH1mut glioma. Because TF also increases the aggressiveness of many cancers, the current study explored the contribution of TF suppression to the reduced malignancy of IDH1mut gliomas.
Experimental Design: TF expression was manipulated in patient-derived IDH1mut and IDH1wt glioma cells, followed by evaluation of in vitro and in vivo behavior and analyses of cell signaling pathways.

Results:
A demethylating agent, decitabine, increased F3 transcription and TF-dependent coagulative activity in IDH1mut cells, but not in IDH1wt cells. TF induction enhanced the proliferation, invasion, and colony formation of IDH1mut cells, and increased the intracranial engraftment of IDH1mut GBM164 from 0% to 100% (P = 0.0001). Conversely, TF knockdown doubled the median survival of mice engrafted with IDH1wt/EGFRvIIIamp GBM6, and caused complete regression of IDH1wt/EGFRamp GBM12 (P = 0.001). In vitro and in vivo effects were linked to activation of receptor tyrosine kinases (RTK) by TF through a Src-dependent intracellular pathway, even when extracellular RTK stimulation was blocked. TF stimulated invasion predominately through upregulation of β-catenin.

Conclusions:
These data show that TF suppression is a component of IDH1mut glioma behavior, and that it may therefore be an attractive target against IDH1wt gliomas.
Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes
Authors: Payton Marc , Cheung Hung-Kam , Ninniri Maria Stefania S. , Marinaccio Christian , Wayne William C. , Hanestad Kelly , Crispino John D. , Juan Gloria , Coxon Angela 
Published: September 2018

Abstract
Aurora kinase A and B have essential and non-overlapping roles in mitosis, with elevated expression in a subset of human cancers, including acute myeloid leukemia (AML). In this study, pan-aurora kinase inhibitor (AKI) AMG 900 distinguishes itself as an anti-leukemic agent that is more uniformly potent against a panel of AML cell lines than are isoform-selective AKIs and classic AML drugs. AMG 900 inhibited AML cell growth by inducing polyploidization and/or apoptosis. AMG 900 and aurora-B–selective inhibitor AZD1152-hQPA showed comparable cellular effects on AML lines that do not harbor a FLT3-ITD mutation. AMG 900 was active against P-glycoprotein–expressing AML cells resistant to AZD1152-hQPA and was effective at inducing expression of megakaryocyte-lineage markers (CD41, CD42) on human CHRF-288-11 cells and mouse Jak2V617F cells. In MOLM-13 cells, inhibition of p-histone H3 by AMG 900 was associated with polyploidy, extra centrosomes, accumulation of p53 protein, apoptosis, and cleavage of Bcl-2 protein. Co-administration of cytarabine (Ara-C) with AMG 900 potentiated cell killing in a subset of AML lines, with evidence of attenuated polyploidization. AMG 900 inhibited the proliferation of primary human bone marrow cells in culture, with a better proliferation recovery profile relative to classic antimitotic drug docetaxel. In vivo, AMG 900 significantly reduced tumor burden in a systemic MOLM-13 xenograft model where we demonstrate the utility of 3′-deoxy-3′-18F-fluorothymidine [18F]FLT positron emission tomographic (PET)–CT imaging to measure the antiproliferative effects of AMG 900 in skeletal tissues in mice.
Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells
Authors: Malric Laure , Monferran Sylvie , Delmas Caroline , Arnauduc Florent , Dahan Perrine , Boyrie Sabrina , Deshors Pauline , Lubrano Vincent , Da Mota Dina Ferreira , Gilhodes Julia , Filleron Thomas , Siegfried Aurore , Evrard Solène , Kowalski-Chauvel Aline , Moyal Elizabeth Cohen-Jonathan , Toulas Christine , Lemarié Anthony 
Published: September 2018

Abstract

Glioblastomas (GB) are malignant brain tumors with poor prognosis despite treatment with surgery and radio/chemotherapy. These tumors are defined by an important cellular heterogeneity and notably contain a subpopulation of GB-initiating cells (GIC), which contribute to tumor aggressiveness, resistance, and recurrence. Some integrins are specifically expressed by GICs and could be actionable targets to improve GB treatment. Here, integrin β8 (ITGB8) was identified as a potential selective target in this highly tumorigenic GIC subpopulation. Using several patient-derived primocultures, it was demonstrated that ITGB8 is overexpressed in GICs compared with their differentiated progeny. Furthermore, ITGB8 is also overexpressed in GB, and its overexpression is correlated with poor prognosis and with the expression of several other classic stem cell markers. Moreover, inhibiting ITGB8 diminished several main GIC characteristics and features, including self-renewal ability, stemness, migration potential, and tumor formation capacity. Blockade of ITGB8 significantly impaired GIC cell viability via apoptosis induction. Finally, the combination of radiotherapy and ITGB8 targeting radiosensitized GICs through postmitotic cell death.

Implications:
This study identifies ITGB8 as a new selective marker for GICs and as a promising therapeutic target in combination with chemo/radiotherapy for the treatment of highly aggressive brain tumors.