bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of tibialis anterior and gastrocnemius muscles activation on balance training devices and hoverboard
Authors: Abdul Rahman Khairiyah , Azaman Aizreena , Mohd Latip Hadafi Fitri , Mat Dzahir Mohd Azuwan , Balakrishnan Malarvili 
Published: April 2018

Balance training devices such as wobble board, basu ball and balance cushion are the tool use in balance training exercise programme in order to improve muscle strength and restore posture balance due degeneration of body function or injury. Recently, self-balancing scooter such as Segway and hover board showed a positive effects on rehabilitation. However, it is less known how these devices affect muscle physiological properties. This study aims to to measure ankle muscles activation on difference balance training devices and hover board. Besides, a comparison between these device will be done in order to identify if hover board has a promising feature to be an alternative balance training device. In this research, surface EMG (sEMG) was used to record tibialis anterior and gastrocnemius muscle activities. Seventeen healthy subjects were required to stand on three different types of balance training device such as wobble board, balance cushion, bosu ball and a hover board. They were asked to maintain their standing position on each devices for two minutes. Both time domain and frequency domain analysis were used to identify the features of the EMG signal. Time domain analysis measurement involved average rectified value (ARV) and root mean square (RMS), meanwhile for frequency domain, median frequency (MDF) of the signal were measured. The results shows that, the RMS is differed significantly between the balance training devices (p<0.05) for tibialis anterior muscle but not gastrocnemius muscle. Meanwhile, no significant difference between the devices in the ARV and the MDF value (p>0.05). Besides, less stable devices increased muscle activity were observed. There is not much difference between hover board and the other devices in term of physiological effects of both tibialis anterior and gastrochemious muscle. It is also suggested that hover board offers a promising feature to be an alternative device for balance training device.
Effects of preoperative intrathecal morphine on postoperative intravenous morphine dosage: a systematic review protocol
Authors: Pitre Luke , Garbee Deborah , Tipton Julia , Schiavo Julie , Pitt Andrew 
Published: April 2018

Review question/objective:
The purpose of this systematic review is to describe the effect of preoperative intrathecal morphine (ITM) on postoperative intravenous (IV) morphine dosage during the first postoperative day. This systematic review will compare the postoperative IV morphine dosage of patients receiving ITM plus morphine morphine-based patient-controlled analgesia (PCA), to patients receiving PCA morphine without ITM. This will establish the magnitude of the postoperative morphine sparing effect of ITM.
This review aims to answer the following specific question: In adult abdominal and thoracic surgery patients undergoing general anesthesia (GA), what is the effect of ITM plus PCA morphine, compared to PCA morphine alone, on total IV morphine dosage (in milligrams) during the first 24 hours after surgery?
Experiences of children exposed to parental post-traumatic stress disorder while growing up in military and veteran families: a systematic review protocol
Authors: Cramm Heidi , Murphy Susanne , Godfrey Christina M. , Dekel Rachel , McKeown Sandra 
Published: April 2018

Review question/objective:
The objective of this review is to understand how parental Post-Traumatic Stress Disorder (PTSD) might impact children growing up in military and veteran families. The following question will guide and inform the review: What is the experience of children growing up in military families where the military or veteran parent is living with post-traumatic stress disorder?
Treatment of nipple pain in breastfeeding women in the postpartum ward of the University Hospital of Lausanne: a best practice implementation project
Authors: Avignon Valerie 
Published: April 2018

ABSTRACT

Introduction
Breast milk represents the optimal nutrition for a child and is recommended during the first six months. However, nipple pain often occurs during the onset of lactation and may affect breastfeeding and exclusive breastfeeding duration rates. Multiple treatments are available in the postpartum units of the Lausanne University Hospital (CHUV, Lausanne, Switzerland) and are used empirically, according to caregiver preferences.

Objectives
The aim of this project is to implement a care plan for nipple pain according to best recommendations and evidence-based studies.

Methods
The project was developed using the Joanna Briggs Institute framework and Practical Application of Clinical Evidence System (JBI-PACES). Five audit criteria were used in pre- and post-audits to observe any changes in compliance with the recommendations. The Getting Research into Practice (GRiP) was used between audits to identify stakeholders, barriers and facilitators of the project.

Results
Compliance in four criteria improved, with no increase in pain experienced by breastfeeding mothers. More women received adequate information (from 47% to 64%) and support (from 47% to 58%). Each item under criteria 2 (adequate information) and 3 (adequate support) showed improvement. The adequate management of nipple pain also increased from 8% to 31%. However, it remains an important issue to consider.

Conclusions
Despite the limitations associated with small samples, the results of this project show that implementation of best practice is possible, even though it involved the withdrawal of unnecessary treatment. Another evaluation is necessary in the future to consolidate and improve these results.
Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic
Authors: Morrison Janna L. , Botting Kimberley J. , Darby Jack R. T. , David Anna L. , Dyson Rebecca M. , Gatford Kathryn L. , Gray Clint , Herrera Emilio A. , Hirst Jonathan J. , Kim Bona , Kind Karen L. , Krause Bernardo J. , Matthews Stephen G. , Palliser Hannah K. , Regnault Timothy R. H. , Richardson Bryan S. , Sasaki Aya , Thompson Loren P. , Berry Mary J. 
Published: April 2018

AbstractOver 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual's risk of non‐communicable disease in later life: the developmental origins of health and disease (DOHaD) hypothesis. During the 1990s the validity of the DOHaD hypothesis was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in thein uterodevelopment between humans and guinea pigs, the strengths and limitations of the guinea pig as an experimental model of DOHaD and the guinea pig's potential to enhance clinical therapeutic innovation to improve human health.image
Cezomycin Is Activated by CalC to Its Ester Form for Further Biosynthesis Steps in the Production of Calcimycin in Streptomyces chartreusis NRRL 3882
Authors: Wu Hao , Liang Jingdan , Wang Jialiang , Liang Wei-Jun , Gou Lixia , Wu Qiulin , Zhou Xiufen , Bruce Ian J. , Deng Zixin , Wang Zhijun 
Published: April 2018

ABSTRACT

Calcimycin, N-demethyl calcimycin, and cezomycin are polyether divalent cation ionophore secondary metabolites produced by
Streptomyces chartreusis
. A thorough understanding of the organization of their encoding genes, biosynthetic pathway(s), and cation specificities is vitally important for their efficient future production and therapeutic use. So far, this has been lacking, as has information concerning any biosynthetic relationships that may exist between calcimycin and cezomycin. In this study, we observed that when a Cal
−
(
calB1
mutant) derivative of a calcimycin-producing strain of
S. chartreusis
(NRRL 3882) was grown on cezomycin, calcimycin production was restored. This suggested that calcimycin synthesis may have resulted from postsynthetic modification of cezomycin rather than from a
de novo
process through a novel and independent biosynthetic mechanism. Systematic screening of a number of Cal
−
S. chartreusis
mutants lacking the ability to convert cezomycin to calcimycin allowed the identification of a gene, provisionally named
calC
, which was involved in the conversion step. Molecular cloning and heterologous expression of the CalC protein along with its purification to homogeneity and negative-staining electron microscopy allowed the determination of its apparent molecular weight, oligomeric forms in solution, and activity. These experiments allowed us to confirm that the protein possessed ATP pyrophosphatase activity and was capable of ligating coenzyme A (CoA) with cezomycin but not 3-hydroxyanthranilic acid. The CalC protein's apparent

K
m

and
k
cat
for cezomycin were observed to be 190 μM and 3.98 min
−1
, respectively, and it possessed the oligomeric form in solution. Our results unequivocally show that cezomycin is postsynthetically modified to calcimycin by the CalC protein through its activation of cezomycin to a CoA ester form.

IMPORTANCE
Calcimycin is a secondary metabolite divalent cation-ionophore that has been studied in the context of human health. However, detail is lacking with respect to both calcimycin's biosynthesis and its biochemical/biophysical properties as well as information regarding its, and its analogues', divalent cation binding specificities and other activities. Such knowledge would be useful in understanding how calcimycin and related compounds may be effective in modifying the calcium channel ion flux and might be useful in influencing the homeostasis of magnesium and manganese ions for the cure or control of human and bacterial infectious diseases. The results presented here unequivocally show that CalC protein is essential for the production of calcimycin, which is essentially a derivative of cezomycin, and allow us to propose a biosynthetic mechanism for calcimycin's production.
Comparison of Diagnostic Accuracy of Periprosthetic Tissue Culture in Blood Culture Bottles to That of Prosthesis Sonication Fluid Culture for Diagnosis of Prosthetic Joint Infection (PJI) by Use of Bayesian Latent Class Modeling and IDSA PJI Criteria for Classification
Authors: Yan Qun , Karau Melissa J. , Greenwood-Quaintance Kerryl E. , Mandrekar Jayawant N. , Osmon Douglas R. , Abdel Matthew P. , Patel Robin 
Published: April 2018

ABSTRACT

We have previously demonstrated that culturing periprosthetic tissue in blood culture bottles (BCBs) improves sensitivity compared to conventional agar and broth culture methods for diagnosis of prosthetic joint infection (PJI). We have also shown that prosthesis sonication culture improves sensitivity compared to periprosthetic tissue culture using conventional agar and broth methods. The purpose of this study was to compare the diagnostic accuracy of tissue culture in BCBs (subsequently referred to as tissue culture) to prosthesis sonication culture (subsequently referred to as sonicate fluid culture). We studied 229 subjects who underwent arthroplasty revision or resection surgery between March 2016 and October 2017 at Mayo Clinic in Rochester, Minnesota. Using the Infectious Diseases Society of America (IDSA) PJI diagnostic criteria (omitting culture criteria) as the gold standard, the sensitivity of tissue culture was similar to that of the sonicate fluid culture (66.4% versus 73.1%,
P
= 0.07) but was significantly lower than that of the two tests combined (66.4% versus 76.9%,
P
< 0.001). Using Bayesian latent class modeling, which assumes no gold standard for PJI diagnosis, the sensitivity of tissue culture was slightly lower than that of sonicate fluid culture (86.3% versus 88.7%) and much lower than that of the two tests combined (86.3% versus 99.1%). In conclusion, tissue culture in BCBs reached sensitivity similar to that of prosthesis sonicate fluid culture for diagnosis of PJI, but the two tests combined had the highest sensitivity without compromising specificity. The combination of tissue culture in BCBs and sonicate fluid culture is recommended to achieve the highest level of microbiological diagnosis of PJI.
Nipah Virus Infection
Authors: Ang Brenda S. P. , Lim Tchoyoson C. C. , Wang Linfa 
Published: April 2018

ABSTRACT
Nipah virus, a paramyxovirus related to Hendra virus, first emerged in Malaysia in 1998. Clinical presentation ranges from asymptomatic infection to fatal encephalitis. Malaysia has had no more cases since 1999, but outbreaks continue to occur in Bangladesh and India. In the Malaysia-Singapore outbreak, transmission occurred primarily through contact with pigs, whereas in Bangladesh and India, it is associated with ingestion of contaminated date palm sap and human-to-human transmission. Bats are the main reservoir for this virus, which can cause disease in humans and animals. There are currently no effective therapeutics, and supportive care and prevention are the mainstays of management.
Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid
Authors: Ning Jiying , Zhong Zhou , Fischer Douglas K. , Harris Gemma , Watkins Simon C. , Ambrose Zandrea , Zhang Peijun 
Published: April 2018

ABSTRACT

Cleavage and polyadenylation specificity factor 6 (CPSF6) is a human protein that binds HIV-1 capsid and mediates nuclear transport and integration targeting of HIV-1 preintegration complexes. Truncation of the protein at its C-terminal nuclear-targeting arginine/serine-rich (RS) domain produces a protein, CPSF6-358, that potently inhibits HIV-1 infection by targeting the capsid and inhibiting nuclear entry. To understand the molecular mechanism behind this restriction, the interaction between CPSF6-358 and HIV-1 capsid was characterized using
in vitro
and
in vivo
assays. Purified CPSF6-358 protein formed oligomers and bound
in vitro
-assembled wild-type (WT) capsid protein (CA) tubes, but not CA tubes containing a mutation in the putative binding site of CPSF6. Intriguingly, binding of CPSF6-358 oligomers to WT CA tubes physically disrupted the tubular assemblies into small fragments. Furthermore, fixed- and live-cell imaging showed that stably expressed CPSF6-358 forms cytoplasmic puncta upon WT HIV-1 infection and leads to capsid permeabilization. These events did not occur when the HIV-1 capsid contained a mutation known to prevent CPSF6 binding, nor did they occur in the presence of a small-molecule inhibitor of capsid binding to CPSF6-358. Together, our
in vitro
biochemical and transmission electron microscopy data and
in vivo
intracellular imaging results provide the first direct evidence for an oligomeric nature of CPSF6-358 and suggest a plausible mechanism for restriction of HIV-1 infection by CPSF6-358.

IMPORTANCE
After entry into cells, the HIV-1 capsid, which contains the viral genome, interacts with numerous host cell factors to facilitate crucial events required for replication, including uncoating. One such host cell factor, called CPSF6, is predominantly located in the cell nucleus and interacts with HIV-1 capsid. The interaction between CA and CPSF6 is critical during HIV-1 replication
in vivo
. Truncation of CPSF6 leads to its localization to the cell cytoplasm and inhibition of HIV-1 infection. Here, we determined that truncated CPSF6 protein forms large higher-order complexes that bind directly to HIV-1 capsid, leading to its disruption. Truncated CPSF6 expression in cells leads to premature capsid uncoating that is detrimental to HIV-1 infection. Our study provides the first direct evidence for an oligomeric nature of truncated CPSF6 and insights into the highly regulated process of HIV-1 capsid uncoating.
Prevalence and treatment of panic disorder in bipolar disorder: systematic review and meta-analysis
Authors: Preti Antonio , Vrublevska Jelena , Veroniki Areti Angeliki , Huedo-Medina Tania B , Kyriazis Odysseas , Fountoulakis Konstantinos N 
Published: April 2018

QuestionRecent data suggest that anxiety disorders are as often comorbid with bipolar disorder (BD) as with unipolar depression. The literature on panic disorder (PD) comorbid with BD has been systematically reviewed and subject to meta-analysis.Study selection and analysisThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were thoroughly followed for literature search, selection and reporting of available evidence. The variance-stabilising Freeman-Tukey double arcsine transformation was used in the meta-analysis of prevalence estimates. Both fixed-effect and random-effects models with inverse variance method were applied to estimate summary effects for all combined studies. Heterogeneity was assessed and measured with Cochran’s Q and I2 statistics.FindingsOverall, 15 studies (n=3391) on cross-sectional prevalence and 25 independent lifetime studies (n=8226) were used to calculate pooled estimates. The overall random-effects point prevalence of PD in patients with BD, after exclusion of one potential outlier study, was 13.0% (95% CI 7.0% to 20.3%), and the overall random-effects lifetime estimate, after exclusion of one potential outlier study, was 15.5% (95% CI 11.6% to 19.9%). There were no differences in rates between BD-I and BD-II. Significant heterogeneity (I2 >95%) was found in both estimates.ConclusionsEstimates that can be drawn from published studies indicate that the prevalence of PD in patients with BD is higher than the prevalence in the general population. Comorbid PD is reportedly associated with increased risk of suicidal acts and a more severe course. There is no clear indication on how to treat comorbid PD in BD. Findings from the current meta-analysis confirm the highly prevalent comorbidity of PD with BD, implicating that in patients with BD, PD might run a more chronic course.
An inductorless active mixer using stacked nMOS/pMOS configuration and LO shaping technique
Authors: Guo Benqing , Chen Jun , Wang Xuebing , Chen Hongpeng 
Published: April 2018

In this paper, a CMOS active down-conversion mixer is presented for wideband applications. Specifically, a LO generation chain is suggested to convert AC LO signal to shaped trapezoid burst, which reduces the sinusoidal LO power level requirement by the mixer. The current-reuse technique by stacked nMOS/pMOS architecture is used to save the power consumption of the circuit. Moreover, this complementary configuration is also employed to compensate second-order nonlinearity of the circuit. Implemented in a 0.18-[Formula: see text]m CMOS process, post-simulations show that, driven by only −10 dBm sinusoidal LO signal, the proposed inductorless mixer provides a maximal conversion gain of 15.7 dB and a noise figure (NF) of 9.1–12 dB across RF input frequency range 0.5–1.6 GHz. The IIP3 and IP1dB of 3.5 dBm and −4.8 dBm are obtained, respectively. The mixer core only consumes 3.6 mW from a 1.8-V supply.
Finite groups with an automorphism inverting, squaring or cubing a non-negligible fraction of elements
Authors: Bors Alexander 
Published: April 2018

Finite groups with an automorphism mapping a sufficiently large proportion of elements to their inverses, squares and cubes have been studied for a long time, and the gist of the results on them is that they are “close to being abelian”. In this paper, we consider finite groups [Formula: see text] such that, for a fixed but arbitrary [Formula: see text], some automorphism of [Formula: see text] maps at least [Formula: see text] many elements of [Formula: see text] to their inverses, squares and cubes. We will relate these conditions to some parameters that measure, intuitively speaking, how far the group [Formula: see text] is from being solvable, nilpotent or abelian; most prominently the commuting probability of [Formula: see text], i.e. the probability that two independently uniformly randomly chosen elements of [Formula: see text] commute. To this end, we will use various counting arguments, the classification of the finite simple groups and some of its consequences, as well as a classical result from character theory.
Targeting NAD+/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma
Authors: Pang Ying , Lu Yanxin , Caisova Veronika , Liu Yang , Bullova Petra , Huynh Thanh-Truc , Zhou Yiqiang , Yu Di , Frysak Zdenek , Hartmann Igor , Taïeb David , Pacak Karel , Yang Chunzhang 
Published: April 2018

Abstract
Purpose: Cluster I pheochromocytomas and paragangliomas (PCPGs) tend to develop malignant transformation, tumor recurrence, and multiplicity. Transcriptomic profiling suggests that cluster I PCPGs and other related tumors exhibit distinctive changes in the tricarboxylic acid (TCA) cycle, the hypoxia signaling pathway, mitochondrial electron transport chain, and methylation status, suggesting that therapeutic regimen might be optimized by targeting these signature molecular pathways.
Experimental Design: In the present study, we investigated the molecular signatures in clinical specimens from cluster I PCPGs in comparison with cluster II PCPGs that are related to kinase signaling and often present as benign tumors.
Results: We found that cluster I PCPGs develop a dependency to mitochondrial complex I, evidenced by the upregulation of complex I components and enhanced NADH dehydrogenation. Alteration in mitochondrial function resulted in strengthened NAD+ metabolism, here considered as a key mechanism of chemoresistance, particularly, of succinate dehydrogenase subunit B (SDHB)-mutated cluster I PCPGs via the PARP1/BER DNA repair pathway. Combining a PARP inhibitor with temozolomide, a conventional chemotherapeutic agent, not only improved cytotoxicity but also reduced metastatic lesions, with prolonged overall survival of mice with SDHB knockdown PCPG allograft.
Conclusions: In summary, our findings provide novel insights into an effective strategy for targeting cluster I PCPGs, especially those with SDHB mutations. Clin Cancer Res; 24(14); 3423–32. ©2018 AACR.