bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi media Scrapbook dengan pemetaan pikiran dalam pembelajaran i'rab di dalam buku Bahasa Arab bagi siswa kelas 7 Mts Midanut Ta'lim Mayanga Jogorot Jombang
Authors: Dwiitra Vikawati  , Dr. Lailatul Qomariyah, M.Pd.I  
Published: November 2024

في التعليم، هناك حاجة إلى وسيلة يكون استخدامها مفيدًا كوسيلة لربط عملية التعلم بين المعلم والطلاب. وسيلة سكرابوك بميزة دعم التعليم الممتع. تم تجهيز وسيلة سكرابوك هذه بقاعدة خريطة الذهنية بحيث يمكن تلخيص مواد قواعد الإعراب في قطعة واحدة من الورق المقوى. وبصرف النظر عن ذلك، فإنه يستخدم أيضًا الرسوم التوضيحية الملونة والصور والتصميمات التي يمكن أن تجذب انتباه الطلاب. باستخدام وسيلة سكرابوك بالخريطة الذهنية، يصبح الطلاب متحمسين للتعلم بشكل تفاعلي، والأمر الأكثر تحفيزًا هو القدرة على الاهتمام بتفسيرات المعلم بطريقة ممتعة والإجابة على أسئلة المعلم. أسئلة البحث هي: 1) كيف تطبيق وسيلة سكرابوك “scrapbook” بالخريطة الذهنية في تعليم الإعراب في كتاب اللغة العربية لطلاب الصف السابع في المدرسة المتوسطة الإسلامية الأهلية "ميدان التعليم" مايانجان جوجوروتو جومبانج؟ 2) ما الدوافع و الموانع في تطبيق وسيلة سكرابوك “scrapbook” بالخريطة الذهنية في تعليم الإعراب في كتاب اللغة العربية لطلاب الصف السابع في المدرسة المتوسطة الإسلامية الأهلية "ميدان التعليم" مايانجان جوجوروتو جومبانج؟ ومنهج البحث هو البحث الكيف بالمدخل الصفي. و نوعه بحث دراسة الحالة. أسلوب جمع البيانات هي الملاحظة والمقابلات والتوثيق. و أسلوب تحليل البيانات هو: جمع البيانات، وتقليل البيانات، وعرض البيانات، و التحقيق. و أسلوب صحة البيانات منها يبطل الملاحظة، ترتقية القوة الإرادة و التثليث. أما نتائج هذا البحث وهي: 1) تطبيق وسيلة سكرابوك “scrapbook” بالخريطة الذهنية في تعليم الإعراب ينقسم إلى ثلاث مراحل، وهي مرحلة التخطيط، ومرحلة التنفيذ، ومرحلة تقييم التعليم. وباستخدام هذه الوسيلة، يكون للطلاب تأثير إيجابي على الطلاب، كما يتضح من أنشطة الطلاب الذين يمكنهم لعب دور فعال في الأنشطة الصفية. وبغض النظر عن ذلك، عندما يسأل المعلم، يمكن للطلاب الإجابة وفقًا لما تم شرحه. 2) الدوافع و الموانع أثناء عملية التقديم الإعلامي. الدوافع هي حماس الطلاب، ودعم المعلمين، وتوافر مصادر التعلم. وفي الوقت نفسه، تنقسم هذه العوامل الموانع إلى قسمين، وهما العوامل الداخلية (شخصية الطالب) والعوامل الخارجية (القيود التكنولوجية).
Cancers and erectile dysfunction: a Mendelian randomization study
Authors: Yang Ge , Xiong Yuanguo , Wang Ziwen , Wang Jingsong , Chen Yongchuan , Zhang Hong 
Published: November 2024

PurposeCancer often coexists with erectile dysfunction, yet the causal relationship between them remains unclear. This study aims to investigate the causal link between tumors and ED through Mendelian randomization.MethodData on 13 different cancers, including lung cancer, colorectal cancer, testicular cancer, lymphoma, esophageal cancer, pancreatic cancer, thyroid cancer, bladder cancer and brain cancer were collected from various databases. ED data, comprising 2,205 cases and 164,104 controls, were sourced from the FinnGen project. Primary methods for MR analysis included IVW, MR-Egger, weighted median, and weighted mode.ResultsIVW results revealed associations between colorectal cancer (OR=1.17;95% CI 1.02-1.13, p=0.0252), prostate cancer (OR=1.63;95% CI 1.52-1.75, p&lt;0.001) and liver cancer (OR=0.93;95% CI 0.88 -0.99, p=0.012) with ED.ConclusionMendelian randomization analysis supports that prostate cancer and colorectal cancer are associated with an increased risk of Erectile Dysfunction, whereas liver cancer is linked to a decreased risk of ED. No evidence suggests that ED contributes to an increased risk of prostate cancer.
Clinical application of chromosome microarray analysis and karyotyping in prenatal diagnosis in Northwest China
Authors: Xue ShuYuan , Liu YuTong , Wang LiXia , Zhang Le , Chang Bozhen , Ding GuiFeng , Dai PengGao 
Published: November 2024

IntroductionKaryotyping and chromosome microarray analysis (CMA) are the two main prenatal diagnostic techniques currently used for genetic testing. We aimed to evaluate the value of chromosomal karyotyping and CMA for different prenatal indications.MethodsA total of 2084 amniocentesis samples from pregnant women who underwent prenatal diagnosis from 16 to 22 + 6 weeks of gestation between January 2021 and December 2022 were retrospectively collected. The pregnant women were classified according to different prenatal diagnostic indications and underwent CMA and karyotype analysis. Clinical data were collected, and the results of the CMA and karyotype analysis were statistically analyzed to compare the effects of the two diagnostic techniques.ResultsThe total detection rate of abnormal chromosomes was significantly higher using CMA than karyotype analysis. The detection rate of abnormal chromosomes using CMA was significantly higher than that using karyotyping for ultrasound abnormalities, high-risk serologic screening, adverse pregnancy history, positive noninvasive prenatal test (NIPT) screening, and ultrasound abnormalities combined with adverse pregnancy history indications. Among the fetuses with inconsistent results between the two testing methods, 144 had an abnormal CMA but a normal karyotype, with the highest percentage of pregnant women with ultrasound abnormalities at 38.89% (56/144). CMA had the highest detection rate for structural abnormalities combined with soft-index abnormalities among all ultrasound abnormalities. The highest detection rate of copy number variants in the group of structural abnormalities in a single system was in the genitourinary system (3/29, 10.34%).ConclusionCMA can improve the detection rate of chromosomal abnormalities in patients with ultrasound abnormalities, high-risk serologic screening, adverse maternal history, positive NIPT screening, and ultrasound abnormalities combined with adverse maternal history and can increase the detection rate of chromosomal abnormalities in karyotypic normality by 6.91% (144/2,084), this result is higher than similar studies. However, karyotype analysis remains advantageous over CMA regarding balanced chromosomal rearrangement and detection of low-level chimeras, and the combination of the two methods is more helpful in improving the detection rate of prenatal chromosomal abnormalities.
Macrophage-derived extracellular vesicles from Ascaris lumbricoides antigen exposure enhance Mycobacterium tuberculosis growth control, reduce IL-1β, and contain miR-342-5p, miR-516b-5p, and miR-570-3p that regulate PI3K/AKT and MAPK signaling pathways
Authors: Pushpamithran Giggil , Blomgran Robert 
Published: November 2024

BackgroundHelminth coinfection with tuberculosis (TB) can alter the phenotype and function of macrophages, which are the major host cells responsible for controlling Mycobacterium tuberculosis (Mtb). However, it is not known whether helminth infection stimulates the release of host-derived extracellular vesicles (EVs) to induce or maintain their regulatory network that suppresses TB immunity. We previously showed that pre-exposure of human monocyte-derived macrophages (hMDMs) with Ascaris lumbricoides protein antigens (ASC) results in reduced Mtb infection-driven proinflammation and gained bacterial control. This effect was entirely dependent on the presence of soluble components in the conditioned medium from helminth antigen-pre-exposed macrophages.MethodsOur objective was to investigate the role of EVs released from helminth antigen-exposed hMDMs on Mtb-induced proinflammation and its effect on Mtb growth in hMDMs. Conditioned medium from 48-h pre-exposure with ASC or Schistosoma mansoni antigen (SM) was used to isolate EVs by ultracentrifugation. EVs were characterized by immunoblotting, flow cytometry, nanoparticle tracking assay, transmission electron microscopy, and a total of 377 microRNA (miRNA) from EVs screened by TaqMan array. Luciferase-expressing Mtb H37Rv was used to evaluate the impact of isolated EVs on Mtb growth control in hMDMs.ResultsEV characterization confirmed double-membraned EVs, with a mean size of 140 nm, expressing the classical exosome markers CD63, CD81, CD9, and flotillin-1. Specifically, EVs from the ASC conditioned medium increased the bacterial control in treatment-naïve hMDMs and attenuated Mtb-induced IL-1β at 5 days post-infection. Four miRNAs showed unique upregulation in response to ASC exposure in five donors. Pathway enrichment analysis showed that the MAPK and PI3K-AKT signaling pathways were regulated. Among the mRNA targets, relevant for regulating inflammatory responses and cellular stress pathways, CREB1 and MAPK13 were identified. In contrast, SM exposure showed significant regulation of the TGF-β signaling pathway with SMAD4 as a common target.ConclusionOverall, our findings suggest that miRNAs in EVs released from helminth-exposed macrophages regulate important signaling pathways that influence macrophage control of Mtb and reduce inflammation. Understanding these interactions between helminth-induced EVs, miRNAs, and macrophage responses may inform novel therapeutic strategies for TB management.
Case report: Metagenomic next-generation sequencing for the diagnosis of rare Nocardia aobensis infection in a patient with immune thrombocytopenia
Authors: Liang Xiaocui , Liu Xiaoyu , Huang Zhimin , Qiu Fei , Jiang Yini , Li Chunhong , Deng Zhenfeng , Wu Jinyu 
Published: November 2024

BackgroundNocardiosis poses a diagnostic challenge due to its rarity in clinical practice, non-specific clinical symptoms and imaging features, and the limitations of traditional detection methods. Nocardia aobensis (N. aobensis) is rarely detected in clinical samples. Metagenomic next-generation sequencing (mNGS) offers significant advantages over traditional methods for rapid and accurate diagnosis of infectious diseases, especially for rare pathogens.Case presentationA 52-year-old woman with a history of immune thrombocytopenia for over 2 years was hospitalized for recurrent fever and cough lasting for 10 days. Her initial diagnosis on admission was community-acquired pneumonia, based on chest computed tomography findings of lung inflammation lesion. Empirical treatment with moxifloxacin and trimethoprim-sulfamethoxazole (TMP-SMZ) was initiated. However, her condition failed to improve significantly even after 1 week of treatment. Bronchoalveolar lavage fluid (BALF) subjected to mNGS revealed the presence of N. aobensis, resulting in a diagnosis of pulmonary nocardiosis caused by N. aobensis. This diagnosis was also supported by Sanger sequencing of the BALF. After adjusting the antibiotic regimen to include TMP-SMZ in combination with imipenem, the patient’s condition significantly improved. She was finally discharged with instructions to continue oral treatment with TMP-SMZ and linezolid for 6 months. The patient’s first follow-up 1 month after discharge showed good treatment outcomes but with obvious side effects of the drugs. Consequently, the antibiotic regimen was changed to doxycycline, and the patient continued to improve.ConclusionWe report the first detailed case of pulmonary nocardiosis caused by N. aobensis diagnosed by mNGS. mNGS could be an effective method that facilitates early diagnosis and timely decision-making for the treatment of nocardiosis, especially in cases that involve rare pathogens.
The association between Geriatric Nutritional Risk Index and KSD disease: results from National Health and Nutrition Examination Survey 2007–2018
Authors: Tang Zhicheng , Zhong Hongzheng , Zhi Qingqing , Chen Yinqiu , Zhang JiaHao , Li Zhibiao , Lu Zechao , Liu Can , Tang Fucai , He Zhaohui , Sun Xuan 
Published: November 2024

BackgroundKidney stone disease (KSD) is a widespread problem in urology. But the associations between the Geriatric Nutritional Risk Index (GNRI), an important indicator for assessing the nutritional status of elderly hospitalized patients, and KSD are understudied.ObjectiveUtilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007–2018, our study analyzed the correlation between the GNRI and KSD prevalence at cross-sectional level. The aim of the study was to explore the association between GNRI and the prevalence of KSD to identify potential risk factors and inform prevention and management strategies for KSD.MethodsThis cross-sectional study analyzed data focusing on 26,803 adults (20–80 years) after screening for complete data. It evaluated GNRI, a formula involving albumin, present, and ideal body weight, stratifying participants into quartiles. The primary outcome was the history of KSD, based on self-reports. Covariates included demographic, health, and lifestyle factors. Statistical analysis employed t-tests, ANOVA, Wilcoxon, and Kruskal-Wallis tests, with logistic regression modeling GNRI’s impact on KSD prevalence, assessing odds ratios and potential multicollinearity, and sensitivity analyses excluding individuals with low eGFR and adjusting cycle years.ResultsSignificant disparities are found in GNRI distributions between individuals with and without kidney stones. Higher GNRI levels are more common in kidney stone patients, with 39.249% in the highest quartile versus 33.334% in those without stones. Notably, those in the highest GNRI quartile (Q4) show a lower prevalence of kidney stone disease (KSD) than those in the lowest (Q1), with rates of 11.988% versus 8.631%, respectively (P &lt; 0.0001). Adjusted model results reveal that higher GNRI quartiles (Q3-Q4) correlate with reduced KSD prevalence, with odds ratios of 0.85 (95% CI [0.72, 1.00]) and 0.76 (95% CI [0.65, 0.89]). A nonlinear inverse relationship exists between GNRI levels and KSD prevalence across the population (P &lt; 0.001), confirming that higher GNRI lowers KSD prevalence. Subgroup and sensitivity analyses support these findings.ConclusionThe study underscores a significant, albeit nonlinear, association between elevated GNRI levels and decreased KSD prevalence. This relationship highlights the importance of nutritional assessment and management in KSD prevention strategies.
Spectral Properties of Marennine-like Pigments Reveal Minor Differences Between Blue Haslea Species and Strains
Authors: Latigui Amina , Jacquette Boris , Dittmer Jens , Bardeau Jean-François , Boivin Edouard , Beaulieu Lucie , Pasetto Pamela , Mouget Jean-Luc 
Published: November 2024

Marennine is the specific bluish pigment produced by the marine diatom Haslea ostrearia Gaillon (Simonsen), responsible for the greening of oysters in France’s Atlantic coast. For decades, H. ostrearia was considered the only blue diatom and described as such. However, new blue Haslea species have been described recently, among which Haslea karadagensis Davidovich, Gastineau, and Mouget (Black Sea, Crimea, Ukraine); Haslea provincialis Gastineau, Hansen, and Mouget (Mediterranean Sea, southern France); Haslea silbo Gastineau, Hansen, and Mouget (West Atlantic Ocean, USA); and one not characterized yet, Haslea sp. nov., isolated in Tenerife (Spain). These species produce marennine-like pigments, for which little information is available yet. The present work aims at studying spectral characteristics of these pigments by UV–visible spectrometry, Raman spectrometry, infrared spectrometry, nuclear magnetic resonance, energy-dispersive X-ray spectroscopy, and cyclic voltammetry, and comparing them to those of marennine produced by H. ostrearia strains originating from the north Atlantic Ocean (western France and Macaronesia), and north Pacific Ocean (southwestern USA). Results show that marennine produced by H. ostrearia strains and marennine-like pigments produced by H. provincialis, H. silbo, and Haslea sp. nov. are quite similar regarding their polysaccharide skeleton, and absorption in the UV–visible, infrared, and Raman regions. The most different marennine-like pigment is produced by H. karadagensis, but all Haslea blue pigments studied so far belong to the same family of organic molecules.
Referência e contrarreferência em saúde: a percepção de médicos do Distrito Federal
Authors: Ambrósio Mariana Carvalho , Ferreira Luciana Benevides , Pereira Thiago de Matos Pinto , Lopes Kaio Albano , Jesus Victor Hugo Policena de , Bruneto João Victor Santana , Souza Vitor Antônio Pignatti de , Oliveira Luiz Fernando Fialho de , Luz Pedro Enzo Camargo 
Published: November 2024

O Sistema de Referência e Contrarreferência é um mecanismo que visa auxiliar o princípio da integralidade para pacientes atendidos no Sistema Único de Saúde - SUS, devendo interligar os diferentes níveis de atenção à saúde. Este sistema deve ser capaz de garantir o acesso a diferentes especialidades da saúde para atender os pacientes em todas as necessidades, desde a prevenção até a conclusão do tratamento, de forma holística. Neste estudo, de natureza qualitativa, buscou-se analisar os mecanismos de referência e contrarreferência utilizados por médicos do Distrito Federal, a partir dos relatos de como este sistema é implementado na prática desses profissionais. A coleta de dados foi realizada por meio de um questionário preenchido de forma on-line. Para a interpretação dos dados utilizou-se análise temática embasada nos fundamentos teóricos do SUS. Algumas das dificuldades relatadas pelos participantes foram relacionadas às comunicações e articulação entre as unidades de saúde. Entraves também foram observados na forma como são obtidas as informações sobre os pacientes. Observou-se que este sistema crucial para o bom funcionamento do SUS é mal avaliado pelos médicos em suas práticas diárias, que apresentam queixas sobre seu funcionamento, mas reconhecem a necessidade de um sistema de informações articulado entre os diferentes níveis de saúde. Dessa forma, constatou-se a necessidade de buscar-se as condições e tecnologias necessárias para um melhor acesso às informações entre as diversas unidades de serviço à saúde, a fim de garantir efetividade entre a integralidade e a continuidade de atenção aos pacientes usuários do SUS no Distrito Federal.
Eksistensi Sistem Pendidikan Islam Dalam Implementasi Pemanfaatan Teknologi Informasi Pada Era 4.0
Authors: Henderi  , Khoirunnisa Alfiah , Rafika Ageng Setiani , Juniar Hega Lutfilah 
Published: November 2024

Perubahan terus terjadi di berbagai bidang termasuk bidang pendidikan. Reformasi dalam bidang Pendidikan tidak bisa dihindari, trus berkembang dan mengalami peningkatan. Hal ini tidak terkecuali karena perubahan era yang memasuki Revolusi Industri 4.0. Dalam pendidikan Islam sendiri, sangat dibutuhkan inovasi baru. Dikarenakan sistem lama yang tertinggal semakin tidak menarik dan menutup peluang untuk penggunaan teknologi pendidikan yang maju. Penelitian ini membahas mengenai permasalahan mengenai Pendidikan Islam yang menghadapi perubahan pada era disrupsi, proses dalam menghadapi peluang dan mengambil keuntungan dalam perubahan yang ada. Dalam penelitian ini menggunakan metode literature review dari hasil penelitian sebelumnya. Selain itu, penelitian ini juga menggunakan metode perhitungan Slovin. Hasil penelitian membahas sistem Pendidikan Islam yang menerapkan penggerak otonom untuk mengembangkan inovasi di era 4.0.
Dampak Implementasi Pendidikan Agama Islam Dalam Membentuk Karakter Generasi Milenial Menghadapi Perkembangan Teknologi Digital Pada Sosial Media
Authors: Durachman Yusuf , Supriati Ruli , Santoso Nuke Puji , Suryaman Fitria Marwati 
Published: November 2024

Bangsa yang maju ditentukan dengan karakter warga negaranya yang memiliki moral dan pengetahuan yang tinggi terhadap sesuatu hal yang tabu, terutama generasi muda milenial saat ini yang dimana perkembangan teknologi digital semakin pesat dengan sosial media yang juga dapat berpengaruh dalam menentukan karakter seseorang. Hal ini dibuktikan karena generasi mudalah yang akan menentukan seperti apa bangsanya dinilai oleh negara lain. Dan semua itu, dilandaskan dengan falsafah Pancasila pertama yakni KeTuhanan Yang Maha Esa. Ketika seseorang sudah paham dengan aturan agama maka karakter seseorang menjadi kuat dan tangguh dalam menjadi kehidupan bernegara. Penelitian ini bertujuan untuk membangun karakter generasi milenial di tengah perkembangan teknologi digital pada sosial media menurut pendidikan agama islam. Peran sosial media yang kini melonjak hingga membuat semua orang mudah mengaksesnya sesuai dengan kebutuhan mereka, namun hadirnya sosial media di era digital saat ini membuat seseorang menjadi kehilangan jati diri menjadi faktor permasalahan yang penting untuk dipecahkan. Metode yang digunakan adalah mind mapping. Dengan adanya penelitian ini membuat warga masyarakat lebih merasakan dampak nilai pendidikan agama islam dalam membentuk karakter generasi milenial. Sehingga maraknya sosial media yang semakin mengubah pola hidup masyarakat menjadi lebih tentram tanpa adanya tindak kekerasan atau pelecehan diluar moral.
РОЛЬ АКАДЕМИКА В.А. НАСОНОВОЙ В РАЗВИТИИ РЕВМАТОЛОГИИ КАЗАХСТАНА
Authors: Р.Л. Иванова , М.В.Р.а.В.А. Горемыкина 
Published: November 2024

В данной статье представлена история ревматологии Казахстана и Семипалатинска, роль академика Насоновой В.А для новых направлений развития отечественной ревматологии, а также исследования научной школы профессора Ивановой Р.Л.
This article presents history of rheumatology of Kazakhstan and Semipalatinsk, the role of academician Nasonova V.A for new directions of development of Kazakhstan rheumatology and research scientific school of Professor Ivanova R.L.
Бұл мақалада келтірілген Қазақстан және Семей ревматологиясының тарихы. Академик Н.А. Насонованың ревматологияны дамытудың жаңа бағыттары үшін рөлі, және сол профессор Иванова Р.Л. ғылыми мектебінің зерттеулері.