bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthetic Methodology, SAR and Pharmacology of Commercialized Preparations Employing 1, 2, 4‐Triazole Analogues
Authors: Singh Sucheta , Kaira Meenakshi , Dey Hrithik , Pandey Kailash C. , Tahlan Sumit , Singh Kuldeep 
Published: November 2024

AbstractThe domain of medicinal chemistry has witnessed a notable surge of interest in triazoles owing to their unique structural characteristics and wide range of applications. The versatility of their synthesis methods has facilitated the creation of compound libraries with remarkable pharmacological activities, including antiviral, antiepileptic, anxiolytic, hypnotic/sedatives anticancer, antifungal, and antidepressant activities. Several techniques have been documented in the literature for generating 1,2,4‐triazole derivatives. The mechanisms governing the pharmacological effects of the formulations containing 1,2,4‐triazoles were elucidated and made clear. In addition to reviewing existing marketed formulations, this review explores emerging trends and innovations in this field. This review offers a comprehensive perspective on the importance of triazoles for influencing contemporary research, fostering innovation, and driving technological progress.
On‐Surface Synthesis of Covalently‐Linked Carbaporphyrinoid‐Based Low‐Dimensional Polymers
Authors: Barragán Ana , Urbani Maxence , Gallardo Aurelio , Pérez‐Elvira Elena , Jover Óscar , Lauwaet Koen , Gallego José M. , Miranda Rodolfo , Giovannantonio Marco Di , Écija David , Torres Tomás , Urgel José I. 
Published: November 2024

AbstractThe synthesis of porphyrinoid‐based low‐dimensional polymers has recently attracted considerable interest in view of their intriguing electronic, optical, and catalytic properties. Here, this is introduced by the surface‐assisted synthesis of two carbaporphyrinoid‐based polymers of increasing dimensionality under ultrahigh‐vacuum conditions. The structural and electronic characterization of the resulting polymers has been performed by scanning tunneling and non‐contact atomic force microscopies, complemented by theoretical modeling. First, a carbon‐carbon coupling between dicarbahemiporphyrazine precursors is achieved by thermal activation of their isopropyl substituents via a [3+3] cycloaromatization, giving rise to one‐dimensional (1D) polymers. Second, the same precursor is functionalized with chlorine atoms to complement the [3+3] cycloaromatization with orthogonal dehalogenation and homocoupling, affording two‐dimensional (2D) molecular nanostructures. In addition, both low‐dimensional free‐base porphyrinoid‐based polymers are exposed to an atomic flux of cobalt atoms, giving rise to cobalt‐metalated macrocycles, with the metal atoms coordinated only to the two pyrrolic nitrogens, in contrast to the typical four‐fold coordination that occurs inside tetrapyrroles. This on‐surface protocol renders atomically precise covalently‐linked porphyrinoid polymers and provides promising model systems toward the exploration of low‐coordinated metals with utility in diverse technological areas.
Is There a Correlation Between Readme Content and Project Meta‐Characteristics?
Authors: Venigalla Akhila Sri Manasa , Chimalakonda Sridhar 
Published: November 2024

ABSTRACTContextDevelopers often turn to readme files in GitHub repositories when they intend to contribute, reuse, or extend a project. These files act as a primary source of information, offering insights into various aspects of the repository. The content and organization of readme can have a significant impact on the project's popularity, its development progress, and the growth of its community.ObjectiveWe examine the growth of GitHub repositories through the lens of their meta‐characteristics, which encompass factors like popularity, community engagement, and development progress, to study the relationship of readme files with repository growth. To achieve this, we conduct a correlation analysis to assess the relationship between project meta‐characteristics and the content and organization of a readme file.MethodsTo conduct a correlation analysis between readme files and project meta‐characteristics, we compiled a data set of readme files from 2000 public GitHub repositories, encompassing 10 primary programming languages. We define metrics for popularity, progress, and community engagement meta‐characteristics and analyze the correlation of structural features and categorical content in readme files against these metrics using non‐parametric statistical tests.ResultsThe results are presented from three distinct perspectives of project meta‐characteristics across 10 programming languages. The results reveal a positive and strong association of external reference links, contribution guidelines, and team details in readme files with better popularity and larger community size. However, the influence of contribution guidelines in readme files on rate of progress is not clearly evident.ConclusionThe study was conducted to assess the correlation of readme file content on repository popularity, development progress, and community size. Our experiments revealed positive correlations between readme content and project meta‐characteristics. However, the extent of correlation varied between repositories across programming languages and meta‐characteristics. We discussed the implications of our findings for developers and researchers and have proposed recommendations for repository owners to organize readme files toward increasing the growth of the repositories with better meta‐characteristics.
UK animal therapists’ confidence in executing professional skills in clinical practice
Authors: Sear Alice , Wills Alison P. 
Published: November 2024

AbstractBackgroundVeterinary physiotherapy and hydrotherapy are popular modalities in the UK, yet little is known about the confidence of therapists responsible for performing these treatments. A lack of confidence may have a detrimental impact on patients; therefore, this study investigated the effect of age, species specialisation, educational level, occupation, qualifications, experience and years practising on animal therapists' confidence in executing professional skills.MethodsAn online survey was conducted to collect quantitative data regarding UK‐based therapists’ confidence in the completion of entrustable professional activities (EPAs). In addition, semi‐structured interviews were conducted to explore participants' perceptions of therapy qualifications and their personal experiences in clinical practice.ResultsOccupation, educational level and therapy qualification had a significant effect (p < 0.05) on participants' confidence in performing all EPAs. Experience had a significant effect (p < 0.05) on four EPAs; those with less than 1 year of experience had the lowest confidence scores, with increased experience in the animal industry and as an animal therapist resulting in a rise in confidence.LimitationsThis study relied on participants reporting their own limitations and could have further explored why animal therapists choose to obtain specific qualifications.ConclusionsProviding support to new graduates may improve their confidence. In addition, it is important that qualifications adequately prepare animal therapists for clinical practice.
Some Properties of a Non-hydrostatic Stochastic Oceanic Primitive Equations Model
Authors: Debussche Arnaud , Mémin Etienne , Moneyron Antoine 
Published: November 2024

AbstractIn this chapter, we study how relaxing the classical hydrostatic balance hypothesis affects theoretical aspects of the LU primitive equations well-posedness. We focus on models that sit between incompressible 3D LU Navier-Stokes equations and standard LU primitive equations, aiming for numerical manageability while capturing non-hydrostatic phenomena. Our main result concerns the well-posedness of a specific stochastic interpretation of the LU primitive equations.
Analysis of an epidemiology model with a removal-rate parameter
Authors: Rustein Brenda , Schochet Steve 
Published: November 2024

Abstract
An epidemiology model is presented that interpolates between the classical SIS and SIR models. In contrast to those models, in the SI

$$-\varepsilon \,\hbox {R}-(1-\varepsilon $$

-
ε

R
-
(
1
-
ε

)S model individuals may become infected a finite number of times that is greater than one. Extensions of the model in which one or both of the S and I compartments is divided into sub-compartments allow the computation of the proportion of susceptibles who never get infected or who become infected exactly once. In the singular limit

$$\varepsilon \rightarrow 0$$

ε
→
0

in which the SI

$$-\varepsilon \, \hbox {R}-(1-\varepsilon $$

-
ε

R
-
(
1
-
ε

)S model approaches the SIS model, the number of susceptibles converges uniformly in time but the number of infectives does not converge to the number of infectives in the SIS model. However, appropriately renormalized solutions of the SI

$$-\varepsilon $$

-
ε

R

$$-(1-\varepsilon $$

-
(
1
-
ε

)S model differ for all time by at most

$$O(\varepsilon )$$

O
(
ε
)

from the corresponding solutions to a modified SIS model in which the basic reproduction number decays over time.
Health-related quality of life and symptom-specific functional impairment among patients treated with parenterally administered complement inhibitors for paroxysmal nocturnal hemoglobinuria
Authors: Dingli David , Rizio Avery A. , Broderick Lynne , LaGasse Kaitlin , Rucker Sloan , Carty Michelle K. , Burton Elise , Gordon Shaquilla , Yen Glorian P. , Paulose Jincy , Geevarghese Anumaxine , Lee Soyon 
Published: November 2024

AbstractThis study describes the health-related quality of life (HRQoL) and symptom-specific functional impairment of patients with paroxysmal nocturnal hemoglobinuria (PNH) in a real-world setting. US-based adults with PNH treated with a parenterally administered complement inhibitor (PACI) for ≥ 6 months completed an online, cross-sectional, observational survey; a subset of patients also participated in semi-structured qualitative interviews. The survey included the PROMIS® 29 + 2 Profile v2.1 (PROMIS 29 + 2) to measure HRQoL. The FACIT-Fatigue, Neuro-QOL Item Bank v2.0 Cognitive Function Short Form, and PROMIS Item Bank v1.0 Dyspnea Functional Limitations 10a Short Form measured symptom-specific functional impairment. For each patient with PNH who completed the online survey, 3 age- and sex-matched adults from the general population (GP) also completed the survey. The HRQoL and functional impairment of the PNH sample were compared to that of the GP sample. The association between HRQoL/functional impairment and fatigue severity for the PNH sample was also investigated. Compared to the age- and sex-matched GP sample, patients treated with PACIs for PNH had significantly worse HRQoL and greater functional impairment for all measured domains (p < 0.05). Within the PNH sample, statistically significant associations (p < 0.05) were observed between fatigue severity and HRQoL/functional impairment for all outcomes except the PROMIS 29 + 2 Sleep Disturbance domain. Interview participants described fatigue-related impairments in their physical, social, and cognitive functioning. Despite receiving treatment for PNH, patients experienced deficits in HRQoL and functional impairment, suggesting that opportunities to improve patient-relevant outcomes through treatment should be identified.
Distribution and volume of mitochondria in alveolar epithelial type 1 cells in infant and adult human lungs
Authors: Schierz Arne K. , Rößler Giacomo , Schneider Jan Philipp , Tschanz Stefan A. , Werlein Christopher , Jonigk Danny D. , Schipke Julia , Mühlfeld Christian 
Published: November 2024

AbstractAlveolar epithelial type I (AE1) cells with their wide spatial expansion form approximately 95% of the outer surface area of the air-blood barrier inside the lung. Serial block-face scanning electron microscopy (SBF-SEM) investigations led to the hypothesis that AE1 cell mitochondria are preferentially distributed as aggregates in those parts of AE1 cells that are located above connective tissue pillars between capillaries, thus not increasing the thickness of the diffusion distance for oxygen and carbon dioxide. Furthermore, it was hypothesised that postnatal development requires adapting the amount and distribution of mitochondria in AE1 cells. Human lung samples from three infant (26 and 30 days, 6 months) and three adult (20, 39 and 40 years) samples were investigated by light microscopy, transmission electron microscopy and stereology. The volume fraction of mitochondria was similar in infant and adult lungs with a mean value of 6.3%. The ratio between mitochondrial profiles on top of capillaries or above connective tissue pillars was approximately 3:1 in infants and adults. However, regarding the volume of both cytoplasmic compartments, infants showed a higher number of mitochondrial profiles on top of capillaries while adults showed a higher number above connective tissue pillars. Samples of three additional adult lungs were analysed by confocal laser scanning microscopy. Again, mitochondria were not preferentially found as aggregates above connective tissue pillars. In conclusion, AE1 cell mitochondria were not preferentially found as aggregates, showed the same volume density in infants and adults but differed in distribution between the age groups.
Associations of physical activity and sedentary time with health-related quality of life in patients with localized renal cell cancer: a cross-sectional analysis within the ReLife study
Authors: Vrieling Alina , Maurits Jake S. F. , Gerritsen Job , Buffart Laurien M. , Aben Katja K. H. , Sedelaar J. P. Michiel , Bakker Esmée A. , Kiemeney Lambertus A. L. M. 
Published: November 2024

Abstract
Purpose
This study examined the associations of device-measured moderate-to-vigorous physical activity (MVPA) and sedentary time as well as self-reported MVPA with health-related quality of life (HRQoL) in patients with localized renal cell cancer (RCC) in the recovery phase after surgery.

Methods
At 3 months post-surgery, 341 patients with stage I-III RCC participating in the ReLife study wore an ActivPAL3 device to determine MVPA and sedentary time. The SQUASH questionnaire was used for assessing self-reported MVPA, and the EORTC QLQ-C30 for assessing HRQoL (range 0–100). Multivariable linear regression models were used to examine the cross-sectional associations of MVPA and sedentary time with HRQoL.

Results
The highest (≥ 6.7 h/week) versus lowest (≤ 2.7 h/week) quartile of MVPA was associated with a better global health status (β, 10.2; 95% CI, 5.1, 15.3), summary score (β, 4.6; 95% CI, 1.1, 8.1), physical (β, 7.7; 95% CI, 3.8, 11.6), role (β, 12.4; 95% CI, 4.7, 20.2), and social functioning (β, 7.3; 95% CI, 0.2, 14.4), and lower fatigue (β, − 11.2; 95% CI, − 18.1, − 4.2). Results for self-reported MVPA were in the same direction but weaker. The lowest (≤ 8.8 h/day) versus highest (≥ 11.5 h/day) quartile of sedentary time was associated with better physical functioning (β, 4.6; 95% CI, 0.8, 8.5).

Conclusions
In patients with localized RCC, higher MVPA 3 months post-surgery was associated with better HRQoL outcomes including less fatigue whereas lower sedentary time was only associated with better physical functioning. This information can contribute to the development of physical activity guidelines and interventions to improve HRQoL.
Survivorship care plans and adherence to breast and cervical cancer screening guidelines among cancer survivors in a national sample
Authors: Santos-Teles Marco , Modugu Ganesh , Silva Isabel C. , Bandera Elisa V. , George Mridula , Qin Bo , Smith Jonathan , Stephenson Ruth , Mattes Malcolm D. , Eskander Mariam F. 
Published: November 2024

Abstract
Purpose
The impact of the components of survivorship care plans on adherence to cancer screening guidelines among cancer survivors is limited. We examined the association of receipt of treatment summaries, follow-up instructions, and type of doctor providing survivorship care with adherence to breast cancer screening (BCS) and cervical cancer screening (CCS) guidelines in female cancer survivors.

Methods
A cross-sectional analysis using Behavioral Risk Factor Surveillance System (BRFSS) data from 2014, 2016 and 2018 was conducted. BCS and CCS-eligible women were aged 40–74 and 30–64, respectively. BCS adherence was defined as a mammogram within 2 years and CCS adherence as a pap smear within 3 years or HPV test within 5 years. Univariate analysis with chi-square and multivariable logistic regression are reported.

Results
5,001 BCS and 3,014 CCS-eligible survivors were identified. In the BCS group, recipients of treatment summaries and follow-up instructions were significantly more adherent with BCS (84.1% vs. 77.4%; 83.4% vs. 74%, respectively, p < 0.001). In the CCS group, recipients of follow-up instructions were significantly more adherent with CCS (78.1% vs. 67.7%, p < 0.001). In both groups, there was no significant difference in BCS or CCS based on type of physician providing care (p = 0.087). On multivariate analysis, receipt of follow-up instructions was the only factor significantly associated with BCS (OR:2.81; 95%CI:1.76–4.49) and CCS (OR:3.14; 95%CI:1.88–5.23).

Conclusions
Follow-up instructions, as part of survivorship care plans, have the strongest association with BCS and CCS among female cancer survivors. Additional research should focus on improving the distribution of survivorship care plans, particularly follow-up instructions, as a method to increase BCS and CCS among cancer survivors.
Long-term outcomes following posterior fossa decompression in pediatric patients with Chiari malformation type 1, a population-based cohort study
Authors: El-Hajj Victor Gabriel , Öhlén Erik , Sandvik Ulrika , Pettersson-Segerlind Jenny , Atallah Elias , Jabbour Pascal , Bydon Mohamad , Daniels David J. , Elmi-Terander Adrian , Edström Erik 
Published: November 2024

Abstract

Objective
Posterior fossa decompression for Chiari malformation type I (Chiari 1) is effective and associated with a low risk of complication. However, up to 20% of patients may experience continued deficits or recurring symptoms after surgical intervention. For pediatric patients, there are no established tools to predict outcomes, and the risk factors for unfavorable postoperative outcomes are poorly understood. Hence, our aim was to investigate baseline data and early postoperative predictors of poor outcomes as determined by the Chicago Chiari outcome scale (CCOS).

Methods
All pediatric patients (< 18 years) receiving a posterior fossa decompression for Chiari 1 between the years of 2005 and 2020 at the study center were eligible for inclusion. Patients with congenital anomalies were excluded.

Results
Seventy-one pediatric patients with a median age of 9 years were included. Most patients (58%) were females. Chiari 1 was associated with syringomyelia (51%), scoliosis (37%), and hydrocephalus (7%). Perioperative complications occurred in 13 patients (18%) of which two required additional procedures under general anesthesia. On multivariable proportional odds logistic regression, motor deficits (OR: 0.09; CI95%: [0.01–0.62]; p = 0.015), and surgical complications (OR: 0.16; CI95%: [0.41–0.66]; p = 0.011) were significant predictors of worse outcomes. The presence of syringomyelia was identified as a predictor of better outcomes (OR: 4.42 CI95% [1.02–19.35]; p = 0.048). A persistent hydrocephalus during the early postoperative period after posterior fossa decompression was a strong predictor of worse long-term CCOS (OR: 0.026; CI95%: [0.002–0.328]; p = 0.005).

Conclusion
Results from this study indicate that the existence of motor deficits and syringomyelia prior to surgery, and surgical complications and persistent hydrocephalus despite posterior fossa decompression, were useful predictors of long-term outcome.
Generations of ‘shock absorbers’: women caregivers of young children and their efforts to mitigate food insecurity during the COVID-19 pandemic
Authors: Lindberg R. , Parks C. , Bastian A. , Yaroch A. L. , McKay F. H. , van der Pligt P. , Zinga J. , McNaughton S. A. 
Published: November 2024

Abstract
Despite their status as high-income food producing nations, children and their caregivers, both in the United States (U.S.) and Australia can experience food insecurity. Nutrition researchers formed a joint U.S.-Australia collaboration to help advance food security for households with young children aged 0–5 years. This study investigated food insecurity from the perspective of caregivers, especially their perceptions of the impact of food insecurity on their own childhood, their current life, and for the children in their care. Semi-structured interviews were conducted from July to September 2020 during the COVID-19 pandemic. Participants were recruited in Omaha, Nebraska, U.S. (n = 19) and Melbourne, Victoria, Australia (n = 22), during periods of stay-at-home public health orders. These two case study sites enabled an exploration of some universal, and some context-specific, social, economic, and health conditions that buffer, or exacerbate, food insecurity for families in these neo-liberal political settings. An inductive thematic analysis was conducted and established six themes:growing up poor, lessons learned, feeding a family amidst a pandemic, caregiver coping strategies, food security in the early years and protecting (young) children. Perspectives on local anti-hunger strategies were organized to outline participant’s preferred solutions. Household food insecurity is conceptualized in public policy in the U.S. and Australia as a short-term crisis for people, justifying austere, time-limited and patchwork solutions. A narrative of caregivers’ lived experience of food insecurity suggests that it is inter-generational, and exacerbated by a food system shock (i.e., COVID-19). These findings from two varying cities and nations offer a different conceptualization of the timespan and nature of the phenomenon of food insecurity, challenging a dominant policy narrative and highlighting the inadequacy of current so-called solutions.