bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies on Bacidia (lichenized Ascomycota, Ramalinaceae) in temperate Australia, including Tasmania: saxicolous and terricolous species
Authors: KANTVILAS Gintaras 
Published: July 2018

AbstractDescriptions, illustrations, discussion and an identification key are presented for six saxicolous and terricolous species of the lichen genus Bacidia De Not. occurring in temperate Australia and Tasmania. Three species are described as new to science: B. lithophila Kantvilas from northern Tasmania, characterized by having only brown apothecial pigments and 3–5-septate, acicular ascospores, 23–35×1·5–2·0 µm; B. littoralis Kantvilas from Tasmania, South Australia (Kangaroo Island) and New South Wales, characterized by green and brown apothecial pigments and acicular, 3–7-septate ascospores, 24–48×2·0–3·5 µm; and B. maccarthyi Kantvilas from New South Wales, with pruinose apothecia and long, filiform, 17–25-septate ascospores, 65–115×2·5–4·0 µm. Three further species are reported for the region for the first time: B. bagliettoana (A. Massal. & de Not.) Jatta (Tasmania), B. curvispora Coppins & Fryday (Tasmania) and B. scopulicola (Nyl.) A. L. Sm. (Tasmania, Victoria).
Realist climate ethics: Promoting climate ambition within the Classical Realist tradition
Authors: Symons Jonathan 
Published: July 2018

AbstractWhat is a Classical Realist analysis of climate ethics and politics? Classical Realist ethical analysis differs from ideal normative theory in that it addresses state decision-makers rather than individuals, assumes highly imperfect compliance with the demands of justice, and is concerned with feasibility and transition rather than end-states. Classical Realists urge leaders to prioritise state security over private moral concerns, to assess rival policies against their likely consequences and to seek the ‘lesser evil’ among feasible choices. But how does Realism respond when the prudent pursuit of state security risks rendering much of the planet uninhabitable? In the 1950s, the development of the hydrogen bomb created just such a dilemma as status quo politics now carried a significant risk of thermonuclear omnicide. In response, Hans Morgenthau argued that states should manage systemic risk by working in concert to safeguard expanded, collective national interests. The Classical Realist mode of thought suggests an analogous response to systemic climate risks: states’ conceptions of national interest must expand to include cooperative system-preservation alongside traditional security concerns. Classical Realist arguments might then be mobilised to overcome resistance from vested interests and to support state-directed low carbon innovation, adaptation and mitigation agreements that prioritise ambition over distributional justice.
Insects as sources of iron and zinc in human nutrition
Authors: Mwangi Martin N. , Oonincx Dennis G. A. B. , Stouten Tim , Veenenbos Margot , Melse-Boonstra Alida , Dicke Marcel , van Loon Joop J. A. 
Published: July 2018

AbstractDietary deficiencies in Fe and Zn are globally widespread, causing serious health problems such as anaemia, poor pregnancy outcomes, increased risk of morbidity and mortality, stunted growth and impaired physical and cognitive development. Edible insects, of which a diversity of over 2000 species is available, are dietary components for about 2 billion individuals and are a valuable source of animal protein. In the present paper, we review the available information on Fe and Zn in edible insects and their potential as a source of these micronutrients for the rapidly growing human population. The levels of Fe and Zn present in eleven edible insect species that are mass-reared and six species that are collected from nature are similar to or higher than in other animal-based food sources. High protein levels in edible insect species are associated with high Fe and Zn levels. Fe and Zn levels are significantly positively correlated. Biochemically, Fe and Zn in insects occur predominantly in non-haem forms, bound to the proteins ferritin, transferrin and other transport and storage proteins. Knowledge gaps exist for bioavailability in the human alimentary tract, the effect of anti-nutritional factors in other dietary components such as grains on Fe and Zn absorption and the effect of food preparation methods. We conclude that edible insects present unique opportunities for improving the micronutrient status of both resource-poor and Western populations.
Source and amount of carbohydrate in the diet and inflammation in women with polycystic ovary syndrome
Authors: Barrea Luigi , Marzullo Paolo , Muscogiuri Giovanna , Di Somma Carolina , Scacchi Massimo , Orio Francesco , Aimaretti Gianluca , Colao Annamaria , Savastano Silvia 
Published: July 2018

AbstractHigh carbohydrate intake and low-grade inflammation cooperate with insulin resistance and hyperandrogenism to constitute an interactive continuum acting on the pathophysiology of polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age characterised by oligo-anovulatory infertility and cardiometabolic disorders. The role of insulin in PCOS is pivotal both in regulating the activity of ovarian and liver enzymes, respectively involved in androgen production and in triggering low-grade inflammation usually reported to be associated with an insulin resistance, dyslipidaemia and cardiometabolic diseases. Although an acute hyperglycaemia induced by oral glucose loading may increase inflammation and oxidative stress by generating reactive oxygen species through different mechanisms, the postprandial glucose increment, commonly associated with the Western diet, represents the major contributor of chronic sustained hyperglycaemia and pro-inflammatory state. Together with hyperinsulinaemia, hyperandrogenism and low-grade inflammation, unhealthy diet should be viewed as a key component of the ‘deadly quartet’ of metabolic risk factors associated with PCOS pathophysiology. The identification of a tight diet–inflammation–health association makes the adoption of healthy nutritional approaches a primary preventive and therapeutic tool in women with PCOS, weakening insulin resistance and eventually promoting improvements of reproductive life and endocrine outcomes. The intriguing nutritional–endocrine connections operating in PCOS underline the role of expert nutritionists in the management of this syndrome. The aim of the present review is to provide an at-a-glance overview of the possible bi-directional mechanisms linking inflammation, androgen excess and carbohydrate intake in women with PCOS.
Temporal expression of pluripotency-associated transcription factors in sheep and cattle preimplantation embryos
Authors: Silva P.G.C. , Moura M.T. , Silva R.L.O. , Nascimento P.S. , Silva J.B. , Ferreira-Silva J.C. , Cantanhêde L.F. , Chaves M.S. , Benko-Iseppon A.M. , Oliveira M.A.L. 
Published: July 2018

SummaryPluripotency-associated transcription factors (PATFs) modulate gene expression during early mammalian embryogenesis. Despite a strong understanding of PATFs during mouse embryogenesis, limited progress has been made in ruminants. This work aimed to describe the temporal expression of eight PATFs during both sheep and cattle preimplantation development. Transcript availability of PATFs was evaluated by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) in eggs, cleavage-stage embryos, morulae, and blastocysts. Transcripts of five genes were detected in all developmental stages of both species (KLF5, OCT4, RONIN, ZFP281, and ZFX). Furthermore, CMYC was detected in all cattle samples but was found from cleavage-stage onwards in sheep. In contrast, NR0B1 was detected in all sheep samples but was not detected in cattle morulae. GLIS1 displayed the most significant variation in temporal expression between species, as this PATF was only detected in cattle eggs and sheep cleavage-stage embryos and blastocysts.In silicoanalysis suggested that cattle and sheep PATFs share similar size, isometric point and molecular weight. A phenetic analysis showed two patterns of PATF clustering between cattle and sheep, among several mammalian species. In conclusion, the temporal expression of pluripotency-associated transcription factors differs between sheep and cattle, suggesting species-specific regulation during preimplantation development.
Early survival following in utero myocardial infarction
Authors: Cosgrove Peter , Modi Shan , Lawson Karla , Hancock-Friesen Camille , Johnson Gregory 
Published: July 2018

AbstractIntrauterine myocardial infarction is a rare and frequently fatal diagnosis. It has been presented in the literature only as case reports and short series. We present a case report of a coronary occlusive intrauterine myocardial infarction and survival and present a systematic review of the literature. This is the first summative description of current data on intrauterine and perinatal myocardial infarction. We performed the systematic review based on the guidelines established by the PRISMA statement. Our population of intrauterine and perinatal myocardial infarction included published cases who presented as a live birth within the first 28 postnatal days, and had a diagnosis of myocardial infarction. We conducted descriptive statistics and regression analysis on short-term mortality as the primary outcome. After applying exclusion criteria we described 84 individual cases of myocardial infarction from 63 full-text articles including our own case. Presentation within the first 12 hours was associated with mortality (OR 3.90, p=0.004). Treatment modalities were varied and inconsistently recorded. The aetiologies and comorbidities are varied in our systematic review. We would have a low threshold to perform viral testing, consider anticoagulation early and coronary imaging if feasible. The use of extracorporeal membranous oxygenation may serve as a bridge to cardiac recovery.
Bloodless priming of the cardiopulmonary bypass circuit: determinants of successful transfusion-free operation in neonates and infants with a maximum body weight of 7 kg
Authors: Wloch Alexa , Boettcher Wolfgang , Sinzobahamvya Nicodème , Cho Mi-Young , Redlin Mathias , Dähnert Ingo , Photiadis Joachim 
Published: July 2018

AbstractWe currently perform open-heart procedures using bloodless priming of cardiopulmonary bypass circuits regardless of a patient’s body weight. This study presents results of this blood-saving approach in neonates and infants with a body weight of up to 7 kg. It tests with multivariate analysis factors that affect perioperative transfusion. A total of 498 open-heart procedures were carried out in the period 2014–2016 and were analysed. Priming volume ranged from 73 ml for patients weighing up to 2.5 kg to 110 ml for those weighing over 5 kg. Transfusion threshold during cardiopulmonary bypass was 8 g/dl of haemoglobin concentration. Transfusion factors were first analysed individually. Variables with a p-value lower than 0.2 underwent logistic regression. Extracorporeal circulation was conducted without transfusion of blood in 335 procedures – that is, 67% of cases. Transfusion-free operation was achieved in 136 patients (27%) and was more frequently observed after arterial switch operation and ventricular septal defect repair (12/18=66.7%). It was never observed after Norwood procedure (0/33=0%). Lower mortality score (p=0.001), anaesthesia provided by a certain physician (p=0.006), first chest entry (p=0.013), and higher haemoglobin concentration before going on bypass (p=0.013) supported transfusion-free operation. Early postoperative mortality was 4.4% (22/498). It was lower than expected (6.4%: 32/498). In conclusion, by adjusting the circuit, cardiopulmonary bypass could be conducted without donor blood in majority of patients, regardless of body weight. Transfusion-free open-heart surgery in neonates and infants requires team cooperation. It was more often achieved in procedures with lower mortality score.
Evaluating dose to thyroid gland in women with breast cancer during radiotherapy with different radiation energies at supraclavicular fossa region
Authors: Mirsadraei Marjaneh , Seilanian Toosi Mehdi , Mohebbi Shokoufeh , Khalili-Hezarjaribi Hojjat 
Published: July 2018

AbstractBackground and aimDuring the treatment of breast cancer, radiotherapy to the supraclavicular fossa region results in absorption of radiation by the thyroid gland and consequently leads to hypothyroidism in 40% of patients. The aim of this study was to compare thyroid gland radiation absorption during radiotherapy with different anterioposterior beam radiation of 6–15 and 15–15 MV photon beam energies.Materials and methodsIn total, 29 patients with breast cancer were recruited to this study. Adjuvant radiotherapy with a total dose of 50 Gy was performed for each participant. Thyroid gland dosimetric measurements were evaluated including, mean dose, minimum and maximum dose, and V20, V30, V40 and V50 (percentage of thyroid volume receiving ≥20, ≥30, ≥40 and ≥50 Gy, respectively). The irradiation delivered doses were measured using Prowess Panther treatment planning system (Version 5.5). All data were evaluated using SPSS software.ResultsIn total, 29 subjects with mean age of 53·4±9·4 were studied. According to the obtained results, at 15–15 MV energies, a significantly lower dose was absorbed by the thyroid gland, was observed in contrast to their counterparts who were treated with 6–15 MV photon beam energies.FindingsUsing 15–15 MV photon beam energies field can significantly reduce the absorbed dose to the thyroid gland and consequently can reduce the risk of developing hypothyroidism in breast cancer patients treated with radiotherapy.
Treatment-seeking differences for mental health problems in male- and non-male-dominated occupations: evidence from the HILDA cohort
Authors: Milner A. , Scovelle A. J. , King T. 
Published: July 2018

AbstractBackgroundThere is a well-established gender divide among people who do and do not seek professional help from mental health professionals. Females are typically more likely to report, and seek help for, mental health problems. The current paper sought to examine the role of employment context on help-seeking for mental health issues. We hypothesised that men and women in male-dominated occupations would be less likely to seek help than those in non-male-dominated occupations.MethodsData from the Household, Income and Labour Dynamics in Australia survey were used. Help-seeking, measured in 2013, was defined as whether a person reported attending a mental health professional in the 12 months prior to the survey. The exposure, male- and non-male-dominated occupations (measured in 2012), was defined using census data based on self-reported occupation. Analyses were stratified by gender and controlled for relevant confounders (measured in 2012), including mental health and prior help-seeking. We conducted multivariate logistic and propensity score analyses to improve exchangeability of those exposed and unexposed.ResultsFor males, being in a male-dominated occupation was independently associated with reduced likelihood of help-seeking (OR 0.66, 95% CI 0.46–0.95) in the adjusted model, although this result fell just out of significance in the propensity score analysis. There was no independent effect of being in a male-/non-male-dominated occupation for help-seeking among women.ConclusionsResults suggest that male-dominated occupations may negatively influence help-seeking among males. There is a need for more research to understand this relationship and for workplace-based prevention initiatives.
Continuous Use of Tribenuron-Methyl Selected for Cross-Resistance to Acetolactate Synthase–inhibiting Herbicides in Wild Mustard (Sinapis arvensis)
Authors: Gherekhloo Javid , Hatami Zahra M. , Alcántara-de la Cruz Ricardo , Sadeghipour Hamid R. , De Prado Rafael 
Published: July 2018

AbstractWild mustard (Sinapis arvensis L.) is a weed that frequently infests winter wheat (Triticum aestivum L.) fields in Golestan province, Iran. Tribenuron-methyl (TM) has been used recurrently to control this species, thus selecting for resistant S. arvensis populations. The objectives were: (1) to determine the resistance level to TM of 14 putatively resistant (PR) S. arvensis populations, collected from winter wheat fields in Golestan province, Iran, in comparison to one susceptible (S) population; and (2) to characterize the resistance mechanisms and the potential evolution of cross-resistance to other classes of acetolactate synthase (ALS)-inhibiting herbicides in three populations (AL-3, G-5, and Ag-Sr) confirmed as being resistant (R) to TM. The TM doses required to reduce the dry weight of the PR populations by 50% were between 2.2 and 16.8 times higher than those needed for S plants. The ALS enzyme activity assays revealed that the AL-3, G-5, and Ag-Sr populations evolved cross-resistance to the candidate ALS-inhibiting herbicides from the sulfonylureas (SU), triazolopyrimidines (TP), pyrimidinyl-thiobenzoates (PTB), sulfonyl-aminocarbonyl-triazolinone (SCT), and imidazolinones (IMI) classes. No differences in absorption, translocation, or metabolism of [14C]TM between R and S plants were observed, suggesting that these non-target mechanisms were not responsible for the resistance. The ALS gene of the R populations contained the Trp-574-Leu mutation, conferring cross-resistance to the SU, SCT, PTB, TP, and IMI classes. The Trp-574-Leu mutation in the ALS gene conferred cross-resistance to ALS-inhibiting herbicides in S. arvensis from winter wheat fields in Golestan province. This is the first TM resistance case confirmed in this species in Iran.
KSTP 94, an Open-pollinated Maize Variety Has Postattachment Resistance to Purple Witchweed (Striga hermonthica)
Authors: Mutinda Sylvia Mbula , Masanga Joel , Mutuku J. Musembi , Runo Steven , Alakonya Amos 
Published: July 2018

AbstractStriga spp. are obligate root hemiparasites that constrain cereal production in sub-Saharan Africa. Although purple witchweed [Striga hermonthica (Delile) Benth.] and Asiatic witchweed [Striga asiatica (L.) Kuntze] infect all cereal crops, maize (Zea mays L.) is particularly vulnerable to their infestations. A sustainable control strategy for Striga would be to breed crops with host-based resistance as part of an integrated management plan. In maize, the open-pollinated variety Kakamega Striga-tolerant population of the year 1994 (‘KSTP 94’) has been popularized as a Striga-tolerant/resistant variety. This resistance was earlier reported to result from production of low amounts of sorgomol, a less potent strigolactone. To determine whether KSTP 94 harbors postattachment resistance, we used a soil-free assay based on observation chambers called rhizotrons. We found that the size of Striga seedlings attached to ‘CML 144’ (a susceptible maize inbred line) were 2.5-fold longer than those on KSTP 94. In addition, KSTP 94 had significantly fewer Striga attachments, which corresponded to significantly lower biomass (2.6-fold) compared with CML 144. Histological analysis revealed that the low Striga growth and development while infecting KSTP 94 was due the parasite’s inability to penetrate the host’s endodermis and make effective xylem–xylem connections. We therefore conclude that in addition to preattachment resistance, KSTP 94 exhibits postattachment resistance to S. hermonthica and could therefore be a good genetic source for postattachment resistance breeding.
Thermodynamic Constraints on the Size Distributions of Tropical Clouds
Authors: Garrett Timothy J. , Glenn Ian B. , Krueger Steven K. 
Published: July 2018

AbstractTropical convective clouds evolve over a wide range of temporal and spatial scales, which makes them difficult to simulate numerically. Here we propose that cloud statistical properties can be derived within a simplified time‐independent coordinate system of cloud numbern, saturated static energyh⋆, and cloud perimeterλ. Under the constraint that circulations around cloud edge compete with each other for total buoyant energy and air, we show that the product of cloud number and cloud perimeternλis invariant withλand that cloud number follows a negative exponential with respect to cloud‐edge deviations ofh⋆with respect to the mean. Overall, the summed perimeter of all clouds scales as the square root of the atmospheric static stability. These theoretical results suggest that the complexity of cloud field structures can be viewed statistically as an emergent property of atmospheric bulk thermodynamics. Comparison with a detailed tropical cloud field simulation shows general agreement to within ≤13%. For the sake of developing hypotheses about cloud temporal evolution that are testable in high resolution simulations, the shapes of tropical cloud perimeter distributions are predicted to be invariant as climate warms, although with a modest increase in total cloud amount.
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis
Authors: Maruyama Tomohiro , Baba Takashi , Maemoto Yuki , Hara-Miyauchi Chikako , Hasegawa-Ogawa Minami , Okano Hirotaka James , Enda Yuki , Matsumoto Kei , Arimitsu Nagisa , Nakao Kazuki , Hamamoto Hiroshi , Sekimizu Kazuhisa , Ohto-Nakanishi Takayo , Nakanishi Hiroki , Tokuyama Takeshi , Yanagi Shigeru , Tagaya Mitsuo , Tani Katsuko 
Published: July 2018

AbstractDDHD2/KIAA0725p is a mammalian intracellular phospholipase A1 that exhibits phospholipase and lipase activities. Mutation of the DDHD2 gene causes hereditary spastic paraplegia (SPG54), an inherited neurological disorder characterized by lower limb spasticity and weakness. Although previous studies demonstrated lipid droplet accumulation in the brains of SPG54 patients and DDHD2 knockout mice, the cause of SPG54 remains elusive. Here, we show that ablation of DDHD2 in mice induces age-dependent apoptosis of motor neurons in the spinal cord. In vitro, motor neurons and embryonic fibroblasts from DDHD2 knockout mice fail to survive and are susceptible to apoptotic stimuli. Chemical and probe-based analysis revealed a substantial decrease in cardiolipin content and an increase in reactive oxygen species generation in DDHD2 knockout cells. Reactive oxygen species production in DDHD2 knockout cells was reversed by the expression of wild-type DDHD2, but not by an active-site DDHD2 mutant, DDHD2 mutants related to hereditary spastic paraplegia, or DDHD1, another member of the intracellular phospholipase A1 family whose mutation also causes spastic paraplegia (SPG28). Our results demonstrate the protective role of DDHD2 for mitochondrial integrity and provide a clue to the pathogenic mechanism of SPG54.
Long noncoding RNA Sox2ot and transcription factor YY1 co-regulate the differentiation of cortical neural progenitors by repressing Sox2
Authors: Knauss Jennifer L. , Miao Nan , Kim Seung-Nam , Nie Yanzhen , Shi Yuelin , Wu Tao , Pinto Hugo Borges , Donohoe Mary E. , Sun Tao 
Published: July 2018

AbstractLong noncoding RNAs (lncRNAs) are emerging as key regulators of crucial cellular processes. However, the molecular mechanisms of many lncRNA functions remain uncharacterized. Sox2ot is an evolutionarily conserved lncRNA that transcriptionally overlaps the pluripotency gene Sox2, which maintains the stemness of embryonic stem cells and tissue-specific stem cells. Here, we show that Sox2ot is expressed in the developing mouse cerebral cortex, where it represses neural progenitor (NP) proliferation and promotes neuronal differentiation. Sox2ot negatively regulates self-renewal of neural stem cells, and is predominately expressed in the nucleus and inhibits Sox2 levels. Sox2ot forms a physical interaction with a multifunctional transcriptional regulator YY1, which binds several CpG islands in the Sox2 locus in a Sox2ot-dependent manner. Similar to Sox2ot, YY1 represses NP expansion in vivo. These results demonstrate a regulatory role of Sox2ot in promoting cortical neurogenesis, possibly by repressing Sox2 expression in NPs, through interacting with YY1.