bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation analysis of RBM3 expression in tumor stroma and prognosis of patients with non-small cell lung cancer
Authors: Chen Ling , Ling Dongshuai , Chen Yi , Gai Kai , Liu Yang , Guo Chengye , Zhang Tenglong 
Published: September 2019

Abstract
Objective: To investigate the correlation between the expression of RNA binding motif protein 3 (RBM3) in non-small cell lung cancer (NSCLC) pathological tissue and known risk factors. Methods: A retrospective analysis of the clinical and pathological features of 128 patients with NSCLC from August 1, 2014 to August 1, 2015 was performed. The expression of RBM3 and protein kinase B (AKT) in the tumor stroma was examined by immunohistochemistry and pathological enumeration, followed by analysis of its correlation with prognosis. The survival status of patients was followed up. The relationships between RBM3 and AKT protein expression in tumor stroma with overall survival (OS) and progression-free survival (PFS) were evaluated. Results: The expression of RBM3 was significantly correlated with tumor differentiation ( P =0.012), lymph node metastasis ( P =0.02), T staging ( P =0.041), and AKT expression ( P =0.021). Univariate Kaplan-Meier analysis showed that high expression of RBM3, lymph node metastasis, T staging, and high expression of AKT were prognostic factors in NSCLC ( P <0.05). Multivariate analysis of Cox proportional hazard model showed that high RBM3 expression, lymph node metastasis, and high AKT expression were independent risk factors for prognosis ( P <0.05). Conclusion: RBM3, AKT, and lymph node metastasis are independent prognostic factors for NSCLC, significantly affecting the prognosis of patients possibly through the classical signaling pathway AKT. RBM3 may be a prognostic marker for the overall survival rate of NSCLC and a candidate for the treatment of NSCLC, with potential therapeutic prospects.
Demyelinating Syndrome in Systemic Sclerosis and Neuromyelitis Optica
Authors: Deeb khaled , Eby Jessika , Labault-Santiago Jose 
Published: September 2019

Abstract
INTRODUCTION: The objective of this study is to report a case of a 44-year-old female who presented with intractable hiccups, vomiting, and later complicated with paraplegia. Imaging and sero/immunological studies were consistent with Neuromyelitis Optica (NMO) based on NMO-IgG sero-positivity and transverse myelitis on MRI. Further investigation revealed positive ANA, anti-RNA polymerase III autoantibodies, and Scl-70, leading to a concurrent diagnosis of systemic sclerosis (SSc). The coexistence of these two disease processes, namely systemic sclerosis and neuromyelitis optica, and their underlying clinical manifestations and therapeutic interventions, are seldom reported in literature and are worth reporting. CASE REPORT: The patient was treated with high dose steroids, and subsequently developed malignant hypertension and acute renal failure, later identified as steroid induced scleroderma renal crisis on renal biopsy. Although Neuromyelitis Optica spectrum disorder (NMOSD) has often been associated with various collagen and autoimmune diseases, the coexistence of NMOSD and SSc presented a challenge where patient underwent aggressive physical therapy and necessitated an intervention with Rituximab to achieve an appropriate clinical response. We have received consent forms from the participant in our study, and we have them on file in case they are requested. We have also received patient’s consent for the data presented in this article and Figure 1. CONCLUSION: This report expands on NMOSD associated autoimmune diseases. Systemic Sclerosis is an insidious disease that is often diagnosed late as not all patients often report skin manifestation. The finding suggests that patients presenting with acute neurological manifestations get tested for NMO-IgG/AQP-4 antibodies and other immunological studies based on clinical findings.
Bicapite, KNa2Mg2(H2PV145+O42)·25H2O, a new polyoxometalate mineral with a bicapped Keggin anion from the Pickett Corral mine, Montrose County, Colorado, U.S.A.
Authors: Kampf Anthony R. , Hughes John M. , Nash Barbara P. , Marty Joe 
Published: September 2019

Abstract
Bicapite, KNa2Mg2(H2PV145+O42)·25H2O, is a new mineral species (IMA2018-048) discovered at the Pickett Corral mine, Montrose County, Colorado, U.S.A. Bicapite occurs as square tablets up to about 0.2 mm on edge on montroseite-corvusite-bearing sandstone. Crystals are dark red-brown, often appearing black. The streak is orange, and the luster is vitreous. Bicapite is brittle, has a Mohs hardness of 1½, and displays one excellent cleavage on {100}. The measured density is 2.44(2) g/cm3. Bicapite is uniaxial (+), ω = 1.785(5), ε ≈ 1.81 (white light); pleochroism is red-brown; E &gt; O, slight. The electron probe microanalysis and results of the crystal structure determination provided the empirical formula (based on 67 O apfu) (K1.23Na2.23Mg1.48)Σ4.94[H2.51P1.02(V13.915+Mo0.076+)Σ13.98O42]·25H2O. Bicapite is tetragonal, I4/m, with a = 11.5446(12) Å, c = 20.5460(14) Å, V = 2738.3(6) Å3, and Z = 2. The strongest four lines in the diffraction pattern are [d in Å (I) (hkl)]: 10.14 (100) (002,101); 2.978 (29) (134,206); 2.809 (11) (305); and 2.583 (11) (420,008). The atomic arrangement of bicapite was solved and refined to R1 = 0.0465 for 1008 independent reflections with I &gt; 2σI. The structural unit is a [H2PV125+O40(V5+O)2]7– heteropolyanion composed of 12 distorted VO6 octahedra surrounding a central PO4 tetrahedron and capped on opposite sides by two VO5 square pyramids; the structural unit is a modification of the α-isomer of the Keggin anion, [XM12O40]n–. Charge balance in the structure is maintained by the [KNa2Mg2(H2O)25]7+ interstitial complex. The name bicapite is in recognition of this being the only known mineral with a structure based on a bicapped Keggin anion. The discovery of bicapite and numerous other natural polyoxometalate compounds in the Colorado Plateau uranium/vanadium deposits make that the most productive region found to date for naturally occurring polyoxometalate compounds.
New insights into the evolution of Mississippi Valley-Type hydrothermal system: A case study of the Wusihe Pb-Zn deposit, South China, using quartz in-situ trace elements and sulfides in situ S-Pb isotopes
Authors: Luo Kai , Zhou Jia-Xi , Huang Zhi-Long , Caulfield John , Zhao Jian-Xin , Feng Yue-Xing , Ouyang Hegen 
Published: September 2019

AbstractUnraveling the evolution of Mississippi Valley-type (MVT) hydrothermal system is crucial for understanding ore genesis and exploration. In this paper, we take the Wusihe Pb-Zn deposit in the western Yangtze Block (South China) as a case study, using detailed ore deposit geology, quartz in situ trace elements, and sulfides in situ S-Pb isotopes, to propose a new integrated model for the evolution of MVT hydrothermal system. Four hydrothermal stages were identified in the Wusihe ore district: (I) lamellar pyrite-sphalerite; (II) disseminated, stock-work, and brecciated sphalerite-galena; (III) massive galena, and (IV) veined calcite-bitumen. Within the most representative stage (stage II), Al concentrations in quartz (Q) increase from 8.46–354 ppm (mean 134 ppm) of Q1 to 171–3049 ppm (mean 1062 ppm) of Q2, and then decrease to 3.18–149 ppm (mean 25.4 ppm) of Q3. This trend indicates the role of acid-producing processes that resulted from sulfide precipitation and acid consumption by carbonate buffering. The occurrence of authigenic non-altered K-feldspar provides further evidence that the ore-forming fluids were weakly acidic with pH values of &gt; ~5.5. Moreover, new bulk δ34S values of sulfides (+1.8 to +14.3‰) are overall lower than those previously reported (+7.1 to +20.9‰), implying that in addition to thermochemical sulfate reduction (TSR), bacterial sulfate reduction (BSR) may play an important role in the formation of S2–. In situ δ34S values show a larger range (–4.3 to +26.6‰), and significantly, varies within single grains (up to +12.3‰), suggesting mixing of two isotopically distinct S2– end-members produced by TSR and BSR. The diagenetic and hydrothermal early phase (stage I) sulfides were formed within a nearly closed system of BSR, whereas the formation of late phase (stage II and stage III) sulfides was caused by the input of hydrothermal fluids that promoted TSR. New galena in situ Pb isotopic ratios (206Pb/204Pb = 18.02–18.19, 207Pb/204Pb = 15.66–15.69, and 208Pb/204Pb = 38.14–38.39) suggest that the sources of mineralizing metals in the Wusihe deposit are mainly Proterozoic basement rocks. Hence, a multi-process model (i.e., basin-mountain coupling, fluid mixing, local sulfate reduction, in situ acid-producing and involvement of black shales and carbonate sequences) was responsible for the formation of the Wusihe deposit, while S2– was produced by both TSR and BSR, providing new insights into the evolution of MVT hydrothermal system.
Assessment of inline technique-based water hammer control strategy in water supply systems
Authors: Ben Iffa Ridha , Triki Ali 
Published: September 2019

Abstract
This article discusses and compares the effectiveness of the compound and dual technique-based inline strategy used to upgrade existing steel pipe-based water supply systems. Basically, these techniques are based on splitting the single inline short section, used in the conventional technique, into a couple of two sub-short sections made of two distinct plastic material types: high- and low-density polyethylene (HDPE) and (LDPE). The 1D unconventional water hammer solver based on the method of characteristics was used for numerical computations. Results evidenced that the specific setup of the compound technique based on (HDPE-LDPE) sub-short sections (where the former sub-short section is attached to the hydraulic parts, while the latter is attached to the main steel pipe) is the most prominent configuration providing an acceptable trade-off between attenuation of pressure head surge, and limitation of excessive wave oscillation period spreading. Furthermore, this compound technique setup allowed more important pressure head peak (or crest) attenuation as compared with the dual technique based on (LDPE-LDPE) sub-short sections; while inducing about similar values of wave oscillation period spreading.
Industrial effluent treatment with immersed MBRs: treatability and cost
Authors: Qiblawey Hazim , Judd Simon 
Published: September 2019

Abstract
A comprehensive OPEX analysis for both municipal and industrial wastewaters has been conducted encompassing energy, critical component (membrane) replacement, chemicals consumption, waste disposal and labour. The analysis was preceded by a review of recent data on industrial effluent treatability with reference to published chemical oxygen demand (COD) removal data for four effluent types: food and beverage, textile, petroleum and landfill leachate. Outcomes revealed labour costs to be the most significant of those considered, contributing 50% of the OPEX for a 10,000 m3/day capacity municipal wastewater treatment works. An analysis of the OPEX sensitivity to 12 individual parameters (labour cost, flux, electrical energy cost, membrane life, feed COD, membrane cost, membrane air-scour rate, chemicals cost, waste disposal cost, mixed liquor suspended solids (MLSS) concentration, recirculation ratio, and transmembrane pressure) revealed OPEX to be most sensitive to labour effort and/or costs for all scenarios considered other than a large (100,000 m3/day capacity) works, for which flux and electrical energy costs were found to be slightly more influential. It was concluded that for small- to medium-sized plants cost savings are best made through improving the robustness of plants to limit manual intervention necessitated by unforeseen events, such as electrical/mechanical failure, foaming or sludging.
Panitumumab Induced Forearm Panniculitis in Two Women With Metastatic Colon Cancer
Authors: Domenico Ciliberto , Antonella Ierardi , Benedetto Caroleo , Luigi Scalise , Antonio Cimellaro , Lidia Colangelo , Giuseppe Spaziano , Gallelli Luca 
Published: September 2019

Background:
Panitumumab is an EGFR inhibitor used for the treatment of metastatic
colorectal cancer (mCRC), even if its use is related to skin toxicity.

Case Presentation:
We report the development of forearm panniculitis in two women during the
treatment with Panitumumab (6 mg/Kg intravenous every 2 weeks) + FOLFOX-6 (leucovorin, 5-
fluorouracil, and oxaliplatin at higher dosage) for the treatment of mCRC.

Results:
In both patients, clinical, laboratory and radiological evaluation documented the presence
of a local panniculitis, probably related to panitumumab (Naranjo score: 6). Panatimumab discontinuation
and antimicrobial + corticosteroid treatment induced a remission of skin manifestations.

Conclusion:
We reported for the first time the development of panniculitis during Panitumumab
treatment, and we documented that the treatment with beta-lactams to either fluoroquinolones or
oxazolidinone in the presence of corticosteroid improves clinical symptoms in young patients with
mCRC, without the development of adverse drug reactions or drug-drug interactions.
A Systematic Review and Bioinformatics Study on Genes and micro-RNAs Involving the Transformation of Endometriosis into Ovarian Cancer
Authors: Sheikhvatan Mehrdad , Chaichian Shahla , Moazzami Bahram 
Published: September 2019

Background:
Along with the description of tumorigenesis processes in endometriosisrelated
ovarian cancer, identifying dysregulated miRNAs, the target genes of these miRNAs, and the
processes abnormally affected by dysregulated miRNAs is essential, which was our goal.

Methods:
Two reviewers individually evaluated the articles which collected relevant information including
genes and miRNAs involved in the transformation of endometriosis into ovarian cancer. To
assess the mature sequence of miRNAs and also their chromosomal positions, miRPathDB software
was employed. To determine the main target gene predicted for each considered miRNAs, the TargetScanS
Web server was applied. The interaction of each gene with other genes associated with endometrial-
related ovarian cancer was determined by GeneMANIA software. Finally, to design integrated
model of miRNAs-targeted genes interaction network, the Cytoscape software was used.

Results:
The final number of studies available for analysis was 6 manuscripts including 22 miRNAs
described as involved in the transformation of endometriosis into different subtypes of ovarian cancers
(14 miRNAs up-regulated and 8 miRNAs down-regulated). Three miRNAs of miR-141 (upregulated),
miR-205 (down-regulated), and miR-125b (down-regulated) were revealed as the originator
for genetic interactions leading to carcinogenesis. We could show some common loops and pathways
including uncontrolled cell proliferation and abnormal apoptosis (mediated by PTEN gene induced
by miR-21 and miR-214), and disaggregation and epithelialization (mediated by ZEB1 and
ZEB2 genes induced by miR-200).

Conclusions:
According to our analysis, up-regulation of miR-141 and down-regulation of miR-205
and miR-125b have a central role in transforming endometriosis to ovarian cancer.
Diagnosis in PANDAS: An Update
Authors: Cabrera-Mendoza Brenda , Genis-Mendoza Alma Delia , Nicolini Humberto 
Published: September 2019

Background:The last twenty years have seen major advancements in unraveling the etiology and the identification of biological markers of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococci (PANDAS). However, this body of evidence has not yet been translated into a clinical setting.Objective:We will review the most important studies to date on PANDAS, emphasizing those whose advances could improve the diagnosis of these disorders. We also suggest the need for updated diagnosis criteria integrating the recent findings from the hereby included studies.Methods:Consulting the PubMed database, a literature review of the last twenty-one years (between 1998 and 2019) was carried out using the terms “PANDAS” and “pediatric autoimmune neuropsychiatric disorders” in combination with “diagnosis” and “markers”. The search resulted in 175 hits from which we selected clinical cases, original investigations, and clinical reviews.Results:This review offers a compilation of the most important studies performed to date regarding the clinical presentation and potential biological markers of PANDAS. Moreover, we suggest the refinement of some aspects in the current diagnosis criteria, such as focusing on specific symptoms and the inclusion of neuroimaging and peripheral markers.Conclusion:The identification of specific biological markers in PANDAS is crucial for its diagnosis and opportune treatment. Future research will determine whether PANDAS require separated diagnostic and therapeutic measures or if it should be included in recently proposed categories such as Pediatric Acute Neuropsychiatric Syndrome (PANS) or Childhood Acute Neuropsychiatric Syndrome (CANS).
Transperineal Laser Ablation Treatment for Lower Urinary Tract Symptoms Due to Benign Prostatic Obstruction: Protocol for a Prospective In Vivo Pilot Study
Authors: van Kollenburg Rob A A , van Riel Luigi A M J G , Bloemen Paul R , Oddens Jorg R , de Reijke Theo M , Beerlage Harrie P , de Bruin Daniel Martijn 
Published: September 2019

Background
Standard surgical treatments for lower urinary tract symptoms (LUTS) due to benign prostatic obstruction (BPO) use a transurethral approach. Drawbacks are the need for general or spinal anesthesia and complications such as hematuria, strictures, and cloth retention. Therefore, a minimal invasive technique under local anesthesia is desired to improve patient safety. Recently, SoracteLite transperineal laser ablation (TPLA) has been introduced as a novel minimal invasive treatment for BPO. The system used is unique because 4 laser sources are independently available. This 1064-nm diode laser induces coagulative necrosis. Moreover, TPLA is unique because it has a transperineal approach and can be performed under local anesthesia in an outpatient setting.

Objective
The primary objective of this study is to determine the safety and feasibility of TPLA treatment for men, who are fit for standard surgery, with LUTS due to BPO. The secondary objectives are to determine functional outcomes by flowmetry and patient-reported outcome measures (PROMs), side effects, and tissue changes observed on imaging.

Methods
This study is a prospective, single center, interventional pilot study IDEAL framework stage 2a and will include 20 patients. Eligible patients are men ≥40 years of age, with a prostate volume of 30 to 120 cc, have urodynamically proven bladder outlet obstruction, and have a peak urinary flow of 5 to 15 mL per second. All patients will undergo TPLA of their prostate under local anesthesia by using the EchoLaser system. Depending on the prostate volume, 2 to 4 laser fibers will be placed bilaterally into the prostate. Patient follow-up consists of uroflowmetry, PROMs, and imaging by using contrast-enhanced ultrasound. Total follow-up is 12 months following treatment.

Results
Presently, recruitment of patients is ongoing. Publication of first results is expected by early 2020.

Conclusions
TPLA offers the potential to be a novel minimal invasive technique for treatment of LUTS due to BPO in men fit for standard desobstruction. This study will evaluate the safety and feasibility of TPLA and report on functional outcomes and tissue changes observed on imaging following TPLA treatment.

International Registered Report Identifier (IRRID)
DERR1-10.2196/15687
DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF SALBUTAMOL SULPHATE FROM PHARMACEUTICAL FORMULATIONS
Authors: G. R. GADEKAR  , S. S PATIL  , R. R. SHAH  , D. S. GHODKE  
Published: September 2019

Objective: The present study was undertaken to develop a rapid, simple, specific and economic ultraviolet (UV) spectrophotometric method for estimating the Salbutamol Sulphate (SS) in pharmaceutical formulations.
Methods: The analysis was performed at λ max 276 nm using Sorenson’s isotonic phosphate buffer pH 7 (SIPB pH 7) as blank/diluent. The method was validated by following the analytical performance parameters as suggested by International Conference on Harmonization (ICH) which included accuracy, precision, linearity.
Results: The drug follows the beer’s lambert’s law in the concentration range of 12.5-37.5μg/ml and exhibited good correlation coefficient (0.9997) and excellent mean recovery. Percentage RSD for precision and accuracy of the method was found to be less than 2%. This method was successfully applied for the determination of the Salbutamol Sulphate in commercial brands of Indian market and the results were in good agreement with the label claims. The developed method was suitable and specific to the analysis of Salbutamol Sulphate even in the presence of common excipients.
Conclusion: The obtained results proved that the validated method can be employed for the routine analysis of Salbutamol Sulphate in bulk as well as in the commercial formulations.
MEDICINAL PLANTS OF SELECTED WETLANDS IN PANNISSERY AREA, THRISSUR DISTRICT, KERALA–A PRELIMINARY SURVEY
Authors: ATHIRA K. R. 
Published: September 2019

Objective: Wetlands are vital ecosystem which provides livelihoods for millions of people who live within around them. Man depends on wetlands for most of his needs from time immemorial. The present study is a preliminary step for the identification of valuable medicinal plants in the wetlands of Pannissery area. This attempt was made since it is equally important to understand the traditional medicines and beliefs as well as to have scientific awareness for protection and conservation of the sewetlands.
Methods: Frequent field visits were carried out from September 2018 to January 2019 to collect different Wetland medicinal plants in Pannissery area, Kandanassery Panchayath, Thrissur district. Plants were collected carefully with hand and identified by using the standard literature such as Flora of the Presidency of Madras by J. S. Gamble, 1915-1936. The collected plants were authenticated by a plant Taxonomist Dr. Udayan. P. S. from the Post Graduate and Research Department of Botany, Sree Krishna College, Guruvayur.
Results: A slight alteration of the wetland may result in the disappearance or the extinction of these plants [1].
Conclusion: This will ultimately result in large scale economic loss in terms of the medicinal product. Apart from the loss of plants, this will also result in the loss of local knowledge on the medicinal properties of these plants which very often can't be retrieved. An attempt has been made to document some of the little known medicinal properties of wetland plants used by local community.