bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Frequency Communications Response to Solar Activity in September 2017 as Observed by Amateur Radio Networks
Authors: Frissell Nathaniel A. , Vega Joshua S. , Markowitz Evan , Gerrard Andrew J. , Engelke William D. , Erickson Philip J. , Miller Ethan S. , Luetzelschwab R. Carl , Bortnik Jacob 
Published: January 2019

AbstractNumerous solar flares and coronal mass ejection‐induced interplanetary shocks associated with solar active region AR12673 caused disturbances to terrestrial high‐frequency (HF, 3–30 MHz) radio communications from 4–14 September 2017. Simultaneously, Hurricanes Irma and Jose caused significant damage to the Caribbean Islands and parts of Florida. The coincidental timing of both the space weather activity and hurricanes was unfortunate, as HF radio was needed for emergency communications. This paper presents the response of HF amateur radio propagation as observed by the Reverse Beacon Network and the Weak Signal Propagation Reporting Network to the space weather events of that period. Distributed data coverage from these dense sources provided a unique mix of global and regional coverage of ionospheric response and recovery that revealed several features of storm time HF propagation dynamics. X‐class flares on 6, 7, and 10 September caused acute radio blackouts during the day in the Caribbean with recovery times of tens of minutes to hours, based on the decay time of the flare. A severe geomagnetic storm with Kpmax = 8+ and SYM‐Hmin = −146 nT occurring 7–10 September wiped out ionospheric communications first on 14 MHz and then on 7 MHz starting at ∼1200 UT 8 September. This storm, combined with affects from additional flare and geomagnetic activity, contributed to a significant suppression of effective HF propagation bands both globally and in the Caribbean for a period of 12 to 15 days.
Tectono‐Sedimentary Analysis of the Hyperextended Liwan Sag Basin (Midnorthern Margin of the South China Sea)
Authors: Zhang C. , Su M. , Pang X. , Zheng J. , Liu B. , Sun Z. , Manatschal G. 
Published: January 2019

AbstractAlthough hyperextended rifted margins have been the focus of many recent studies, the potential interaction between tectonic deformation and sedimentation during extreme crustal thinning is poorly understood. In this study, we aim to explore the tectono‐sedimentary evolution during final rifting and lithospheric breakup in the hyperextended Liwan sag basin. We demonstrate the presence of an oceanward inclined shale sequence, which acts as a decoupling level separating a subshale from a suprashale layer. The suprashale layer is characterized by progradational deltaic facies with a high sediment supply to the north and basal facies farther south. Extensional faults together with local gravitational structures are syndepositional and formed during hyperextension. The shale is observed to overlie a highly attenuated basement comprising high‐reflective sequences that may correspond to meta‐sediments. We propose a new model to explain the interaction of tectonic deformation, gravity sliding, and sedimentation. A first stage includes the crustal necking that goes along with the deposition of synrift deltaic sequences decoupled above prodelta shales. During hyperextension, a high sediment supply is linked to migration of depocenters and extension oceanward. The prodelta shale layer acts as the main decoupling level, gravity sliding affects synhyperextensional sediments, and dome‐shape structures start to form. During a third stage, deformation migrates outboard, while formation of dome structures continues in the Liwan sag basin. Although the process controlling these dome‐shape structures remains unclear, a magmatic origin is likely. Diffuse deformation related to differential compaction and minor magmatic additions continued to affect the margin after the onset of seafloor spreading.
Paleoseismic Slip Records and Uplift of the Longmen Shan, Eastern Tibetan Plateau
Authors: Wang H. , Li H. B. , Zhang L. , Zheng Y. , Si J. L. , Sun Z. M. 
Published: January 2019

AbstractWe document the geological fault zone geometry and internal architecture of the Yingxiu‐Beichuan fault (YBF) in the Longmen Shan, eastern Tibetan Plateau, which hosted the catastrophic 2008 Wenchuan earthquake. The YBF has been repeatedly reactivated during its long‐term activity and contains widespread brittle fault rocks. Pseudotachylytes are recognized in the Pengguan Complex both from the Wenchuan earthquake Fault Scientific Drilling (WFSD) cores and at a surface outcrop. Microstructural evidence of embayed and rounded fragments, flow structures, vesicles, and microlites of various morphologies indicate that the pseudotachylytes were generated by frictional melting during earthquakes. Cataclasite and fault gouge with fragments of angular shapes and varied sizes observed within the fault zones are also considered as evidence of paleoearthquakes. These imply that the main fault zones in the WFSD cores record ancient seismic slip events. Geological field mapping at the surface and in WFSD cores shows that the YBF is a listric reverse fault, with a 155–290‐m thick fault zone that dips 73°–68° at depths <700 m and 30° at depths >700 m. Three faulted sets of alternating Neoproterozoic Pengguan Complex overthrusting upon the Late Triassic Xujiahe Formation in the WFSD‐2 core imply that the main tectonic framework of Longmen Shan consists of a series of imbricated thrust sheets that have accommodated strong crustal shortening. These suggest that the accumulated crustal shortening caused by imbricated thrusting and long‐term seismic activity along the YBF and deep concealed faults is an important process responsible for the rapid uplift of the Longmen Shan.
A PDE1 inhibitor reduces adipogenesis in mice via regulation of lipolysis and adipogenic cell signaling
Authors: Kim Nam-Jun , Baek Jung-Hwan , Lee JinAh , Kim HyeNa , Song Jun-Kyu , Chun Kyung-Hee 
Published: January 2019

AbstractVinpocetine, a phosphodiesterase (PDE) type-1 inhibitor, increases cAMP and cGMP levels and is currently used for the management of cerebrovascular disorders, such as stroke, cerebral hemorrhage, and cognitive dysfunctions. In this study, we first determined that vinpocetine effectively suppressed adipogenesis and lipid accumulation. However, we questioned which molecular mechanism is involved because the role of PDE in adipogenesis is still controversial. Vinpocetine decreased adipogenic cell signaling, including the phosphorylation of ERK, AKT, JAK2, and STAT3, and adipokine secretion, including IL-6, IL-10, and IFN-α. Interestingly, vinpocetine increased the phosphorylation of HSL, suggesting the induction of the lipolysis pathway. Moreover, vinpocetine increased UCP1 expression via increasing cAMP and PKA phosphorylation. The administration of vinpocetine with a normal-chow diet (NFD) or a high-fat diet (HFD) in mice attenuated body weight gain in mice fed both the NFD and HFD. These effects were larger in the HFD-fed mice, without a difference in food intake. Vinpocetine drastically decreased fat weight and adipocyte cell sizes in gonadal and inguinal white adipose tissues and in the liver in both diet groups. Serum triacylglycerol levels and fasting blood glucose levels were reduced by vinpocetine treatment. This study suggested that vinpocetine prevents adipocyte differentiation through the inhibition of adipogenesis-associated cell signaling in the early stages of adipogenesis. Moreover, upregulating cAMP levels leads to an increase in lipolysis and UCP1 expression and then inhibits lipid accumulation. Therefore, we suggest that vinpocetine could be an effective agent for treating obesity, as well as improving cognition and cardiovascular function in older individuals.
Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress
Authors: Föcking Melanie , Sabherwal Sophie , Cates Hannah M. , Scaife Caitriona , Dicker Patrick , Hryniewiecka Magdalena , Wynne Kieran , Rutten Bart P. F. , Lewis Glyn , Cannon Mary , Nestler Eric J. , Heurich Meike , Cagney Gerard , Zammit Stanley , Cotter David R. 
Published: January 2019

AbstractThe complement cascade is a major component of the immune defence against infection, and there is increasing evidence for a role of dysregulated complement in major psychiatric disorders. We undertook a directed proteomic analysis of the complement signalling pathway (n = 29 proteins) using data-independent acquisition. Participants were recruited from the UK avon longitudinal study of parents and children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. Protein expression levels at age 12 among individuals who reported psychotic experiences (PEs) at age 18 (n = 64) were compared with age-matched controls (n = 67). Six out of the 29 targeted complement proteins or protein subcomponents were significantly upregulated following correction for multiple comparisons (VTN↑, C1RL↑, C8B↑, C8A↑, CFH↑, and C5↑). We then undertook an unbiased plasma proteomic analysis of mice exposed to chronic social stress and observed dysregulation of 11 complement proteins, including three that were altered in the same direction in individuals with PE (C1R↑, CFH↑, and C5↑). Our findings indicate that dysregulation of the complement protein pathway in blood is associated with incidence of psychotic experiences and that these changes may reflect exposure to stress.
A new case of spastic paraplegia type 64 due to a missense mutation in the ENTPD1 gene
Authors: Mamelona Jean , Crapoulet Nicolas , Marrero Alier 
Published: January 2019

AbstractSpastic paraplegia type 64 (SPG64; OMIM 615683) is a complicated form of hereditary spastic paraplegia (HSP) recently identified in individuals diagnosed with suspected neurodegenerative disease. Affected patients carry homozygous mutations in the ectonucleoside triphosphate diphosphohydrolase 1 gene (ENTPD1). Although they share common characteristics, affected individuals show slight discrepancies in some clinical aspects. At present, only two different cases of SPG64 have been diagnosed. More findings of genetic variation would be helpful to better understand the effect of mutations in the ENTPD1 gene on the neurological condition of affected individuals. In this study, we examined a family with an individual diagnosed with suspected HSP based on clinical findings. DNA samples from the proband, her affected sister, and both parents were analyzed using next-generation sequencing. We used an in-house automated pipeline to detect potential neuromuscular disease-causing variants. Variants were confirmed by Sanger sequencing. After cosegregation analysis, the variant NM_001776.5:c.401T>G (p.M134R) of the ENTPD1 gene was identified as a novel missense mutation linked to the phenotype of SPG64 in the proband and her sister, who showed similar and distinct clinical features compared with the two cases previously described in the literature.
Fetal-derived macrophages dominate in adult mammary glands
Authors: Jäppinen Norma , Félix Inês , Lokka Emmi , Tyystjärvi Sofia , Pynttäri Anne , Lahtela Tiina , Gerke Heidi , Elima Kati , Rantakari Pia , Salmi Marko 
Published: January 2019

AbstractMacrophages serve multiple functions including immune regulation, morphogenesis, tissue homeostasis and healing reactions. The current paradigm holds that mammary gland macrophages first arise postnatally during the prepubertal period from the bone marrow-derived monocytes. Here we delineate the origins of tissue-resident mammary gland macrophages using high-dimension phenotypic analyses, cell-fate mapping experiments, gene-deficient mice lacking selective macrophage subtypes, and antibody-based depletion strategies. We show that tissue-resident macrophages are found in mammary glands already before birth, and that the yolk sac-derived and fetal liver-derived macrophages outnumber the adult-derived macrophages in the mammary gland also in the adulthood. In addition, fetal-derived mammary gland macrophages have a characteristic phenotype, display preferential periductal and perivascular localization, and are highly active in scavenging. These findings identify fetal-derived macrophages as the predominant leukocyte type in the adult mammary gland stroma, and reveal previously unknown complexity of macrophage biology in the breast.
Distinct roles of temporal and frontoparietal cortex in representing actions across vision and language
Authors: Wurm Moritz F. , Caramazza Alfonso 
Published: January 2019

AbstractBoth temporal and frontoparietal brain areas are associated with the representation of knowledge about the world, in particular about actions. However, what these brain regions represent and precisely how they differ remains unknown. Here, we reveal distinct functional profiles of lateral temporal and frontoparietal cortex using fMRI-based MVPA. Frontoparietal areas encode representations of observed actions and corresponding written sentences in an overlapping way, but these representations do not generalize across stimulus type. By contrast, only left lateral posterior temporal cortex (LPTC) encodes action representations that generalize across observed action scenes and written descriptions. The representational organization of stimulus-general action information in LPTC can be predicted from models that describe basic agent-patient relations (object- and person-directedness) and the general semantic similarity between actions. Our results suggest that LPTC encodes general, conceptual aspects of actions whereas frontoparietal representations appear to be tied to specific stimulus types.
Direct access to poly(glycidyl azide) and its copolymers through anionic (co-)polymerization of glycidyl azide
Authors: Boopathi Senthil K. , Hadjichristidis Nikos , Gnanou Yves , Feng Xiaoshuang 
Published: January 2019

AbstractGlycidyl azide polymer or poly(glycidyl azide) which is considered as an excellent energetic binder or plasticizer in advanced solid propellants is generally obtained by post-modification or azidation of poly(epichlorohydrin). Here we report that glycidyl azide can be directly homopolymerized through anionic ring-opening polymerization to access poly(glycidyl azide) using onium salts as initiator and triethyl borane as activator. Molar masses of poly(glycidyl azide) up to 11.0 Kg/mol are achieved in a controlled manner with a narrow polydispersity index (PDI ≤ 1.2). Similarly, alternating poly(glycidyl azide carbonate) are also prepared through alternating copolymerization of glycidyl azide with carbon dioxide. Lastly, the copolymerization of glycidyl azide with other epoxide monomers is carried out; the azido functions carried by glycidyl azide which are successfully incorporated into the backbones of polyethers and polycarbonates based on cyclohexene oxide and propylene oxide subsequently served to introduce other functions by click chemistry.
Ice-VII-like molecular structure of ambient water nanomeniscus
Authors: Shin Dongha , Hwang Jonggeun , Jhe Wonho 
Published: January 2019

AbstractStructural transformations originating from diverse rearrangements of the hydrogen bonding in water create various phases. Although most phases have been well investigated down to the molecular level, the molecular structure of the nanomeniscus, a ubiquitous form of nanoscale water in nature, still remains unexplored. Here, we demonstrate that the water nanomeniscus exhibits the stable, ice-VII-like molecular structure in ambient condition. Surface-enhanced Raman spectroscopy on trace amounts of water, confined in inter-nanoparticle gaps, shows a narrowed tetrahedral peak at 3340 cm-1 in the OH-stretching band as well as a lattice-vibrational mode at 230 cm-1. In particular, the ice-VII-like characteristics are evidenced by the spectral independence with respect to temperature variations and differing surface types including the material, size and shape of nanoparticles. Our results provide un unambiguous identification of the molecular structure of nanoconfined water, which is useful for understanding the molecular aspects of water in various nanoscale, including biological, environments.
MONARCH 3 final PFS: a randomized study of abemaciclib as initial therapy for advanced breast cancer
Authors: Johnston Stephen , Martin Miguel , Di Leo Angelo , Im Seock-Ah , Awada Ahmad , Forrester Tammy , Frenzel Martin , Hardebeck Molly C. , Cox Joanne , Barriga Susana , Toi Masakazu , Iwata Hiroji , Goetz Matthew P. 
Published: January 2019

AbstractAt the MONARCH 3 interim analysis, abemaciclib plus a nonsteroidal aromatase inhibitor (AI) significantly improved progression-free survival (PFS) and objective response rate (ORR) with a tolerable safety profile as initial treatment for hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) advanced breast cancer (ABC). MONARCH 3 is a randomized, phase III, double-blind study of abemaciclib/placebo (150 mg twice daily, continuous) plus nonsteroidal AI (1 mg anastrozole or 2.5 mg letrozole, daily). A total of 493 postmenopausal women with HR+, HER2− ABC with no prior systemic therapy in this setting were enrolled. The primary endpoint was investigator-assessed PFS (final analysis after 240 events); other endpoints included response and safety evaluations. Here we analyze the final PFS data and update secondary endpoints. The abemaciclib arm had a significantly longer median PFS than the placebo arm (28.18 versus 14.76 months; hazard ratio [95% confidence interval], 0.540 [0.418–0.698]; p = .000002). The ORR was 61.0% in the abemaciclib arm versus 45.5% in the placebo arm (measurable disease, p = .003). The median duration of response was longer in the abemaciclib arm (27.39 months) compared to the placebo arm (17.46 months). The safety profile was consistent with previous reports. The most frequent grade ≥ 3 adverse events in the abemaciclib versus placebo arms were neutropenia (23.9% versus 1.2%), diarrhea (9.5% versus 1.2%), and leukopenia (8.6% versus 0.6%). Abemaciclib plus a nonsteroidal AI was an effective initial treatment with an acceptable safety profile for HR+, HER2− ABC.
Implementation Science: Tackling the Research to Practice Gap in Communication Sciences and Disorders
Authors: Douglas Natalie F. , Burshnic Vanessa L. 
Published: January 2019

Purpose
The purpose of this article is to outline how implementation science can contribute to the advancement of communication sciences and disorders through its impact on both clinical research and clinical practice. Implementation science's pertinent definitions and history are discussed. Then, information is highlighted pertaining to the position of implementation science within the larger realm of clinical practice research. An exemplar study is reviewed to inform clinical researchers in communication sciences and disorders.

Conclusion
The importance of implementation science is emphasized by outlining ways that speech-language pathologists and audiologists can use implementation science to both inform their clinical practice and contribute to the evidence base of the disciplines.
Molecular characterization of berry color locus on the portuguese cv. ‘Fernão Pires’ and cv. ‘Verdelho’ and their red-berried somatic variant cultivars
Authors: Ferreira Vanessa , Castro Isaura , Carrasco David , Pinto-Carnide Olinda , Arroyo-García Rosa 
Published: January 2019

Genotyping studies are increasing the knowledge on grapevine biodiversity, particularly regarding grape berry skin color somatic variants, supporting the research on the color trait. This study aimed to evaluate the effect of the berry color locus, and its surrounding genomic region, on the color variation of the Portuguese white-skinned cultivars ‘Fernão Pires’ and ‘Verdelho’ and its derived red-berried somatic variants cv. ‘Fernão Pires Rosado’ and cv. ‘Verdelho Roxo’, respectively.
The analysis of Gret1 insertion within the VvMYBA1 gene revealed no polymorphism responsible for white-to-red shift of the red-skinned cv. ‘Fernão Pires Rosado’ and cv. ‘Verdelho Roxo’. Moreover, VvMYBA2 showed an important role regarding the phenotypic variation of cv. ‘Fernão Pires’, through the recovery of the functional allele G on cv. ‘Fernão Pires Rosado’. Regarding the data obtained for cv. ‘Verdelho’ and cv. ‘Verdelho Roxo’, both cultivars showed Gret1 insertion on VvMYBA1 and non-functional T allele on VvMYBA2 in homozygosity for both cell layers of shoot apical meristem, suggesting the occurrence of other mutational events responsible for the color gain.
Prejudice and the Brexit vote: a tangled web
Authors: Hutchings Paul B. , Sullivan Katie E. 
Published: January 2019

AbstractThe decision of the UK public in July 2016 to vote to leave the European Union was greeted with surprise within the UK and across the world. However, should we really have been surprised? Surveys of attitudes towards freedom of movement to the UK over the last 10 years have suggested an increasing negativity regarding immigration, and many debates before and after the vote have raised the issue of whether prejudice played a role in the outcome of the referendum. It is only within the last 12 months that a number of research study findings have started to provide a more coherent, data-informed evidence-base suggesting that voting behaviour in the referendum may have correlates to prejudice personality styles, nationalism, Islamophobia, and implicit/explicit prejudice. We argue that recent evidence suggests that levels of prejudice towards ‘others’ was a factor in the Brexit vote and that the attitudes underlying this vote must be explored in greater detail through cross-disciplinary scientific research, with legitimate concerns recognised and fallacies challenged.
Identification of an internal cavity in the PhoQ sensor domain for PhoQ activity and SafA-mediated control
Authors: Yoshitani Kohei , Ishii Eiji , Taniguchi Katsuhide , Sugimoto Hiroshi , Shiro Yoshitsugu , Akiyama Yoshinori , Kato Akinori , Utsumi Ryutaro , Eguchi Yoko 
Published: January 2019

ABSTRACT
The PhoQ/PhoP two-component signal transduction system is conserved in various Gram-negative bacteria and is often involved in the expression of virulence in pathogens. The small inner membrane protein SafA activates PhoQ in Escherichia coli independently from other known signals that control PhoQ activity. We have previously shown that SafA directly interacts with the sensor domain of the periplasmic region of PhoQ (PhoQ-SD) for activation, and that a D179R mutation in PhoQ-SD attenuates PhoQ activation by SafA. In this study, structural comparison of wild-type PhoQ-SD and D179R revealed a difference in the cavity (SD (sensory domain) pocket) found in the central core of this domain. This was the only structural difference between the two proteins. Site-directed mutagenesis of the residues surrounding the SD pocket has supported the SD pocket as a site involved in PhoQ activity. Furthermore, the SD pocket has also been shown to be involved in SafA-mediated PhoQ control.