bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profiling the cancer-prone microenvironment in a zebrafish model for MPNST
Authors: Cero Cheryl , House John S. , Verdi Vincenzo , Ferguson Jordan L. , Jima Dereje D. , Selmek Aubrie A. , Patania Olivia M. , Dwyer Jennifer E. , Wei Bih-Rong , Lloyd Dillon T. , Shive Heather R. 
Published: November 2024

Abstract
Microenvironmental contributions to soft tissue sarcoma progression are relatively undefined, particularly during sarcoma onset. Use of animal models to reveal these contributions is impeded by difficulties in discriminating between microenvironmental, precancerous, and cancer cells, and challenges in defining a precancerous microenvironment. We developed a zebrafish model that allows segregation of microenvironmental, precancerous, and cancerous cell populations by fluorescence-activated cell sorting. This model has high predilection for malignant peripheral nerve sheath tumor (MPNST), a type of soft tissue sarcoma that exhibits rapid, aggressive growth. Using RNA-seq, we profiled the transcriptomes of microenvironmental, precancerous, and cancer cells from our zebrafish MPNST model. We show broad activation of inflammation/immune-associated signaling networks, describe gene expression patterns that uniquely characterize the transition from precancerous to cancer ME, and identify macrophages as potential contributors to microenvironmental phenotypes. We identify conserved gene expression changes and candidate genes of interest by comparative genomics analysis of MPNST versus benign lesions in both humans and zebrafish. Finally, we functionally validate a candidate extracellular matrix protein, periostin (POSTN), in human MPNST. This work provides insight into how the microenvironment may regulate MPNST initiation and progression.
An exploratory study of metabolomics in endogenous and cannabis-use-associated psychotic-like experiences in adolescence
Authors: Kurkinen Karoliina , Kärkkäinen Olli , Lehto Soili M. , Luoma Ilona , Kraav Siiri-Liisi , Kivimäki Petri , Therman Sebastian , Tolmunen Tommi 
Published: November 2024

AbstractIn adolescence, psychotic-like experiences (PLE) may indicate potential prodromal symptoms preceding the onset of psychosis. Metabolomic studies have shown promise in providing valuable insights into predicting psychosis with enhanced precision compared to conventional clinical features. This study investigated metabolomic alterations associated with PLE in 76 depressed adolescents aged 14–20 years. Serum concentrations of 92 metabolites were analyzed with liquid chromatography–mass spectrometry. PLE were assessed using the Youth Experiences and Health (YEAH) questionnaire. The associations between PLE symptom dimensions (delusions, paranoia, hallucinations, negative symptoms, thought disorder, and dissociation) and metabolite concentrations were analyzed in linear regression models adjusted for different covariates. The symptom dimensions consistently correlated with the metabolome in different models, except those adjusted for cannabis use. Specifically, the hallucination dimension was associated with 13 metabolites (acetoacetic acid, allantoin, asparagine, decanoylcarnitine, D-glucuronic acid, guanidinoacetic acid, hexanoylcarnitine, homogentisic acid, leucine, NAD+, octanoylcarnitine, trimethylamine-N-oxide, and valine) in the various linear models. However, when adjusting for cannabis use, eight metabolites were associated with hallucinations (adenine, AMP, cAMP, chenodeoxycholic acid, cholic acid, L-kynurenine, neopterin, and D-ribose-5-phosphate). The results suggest diverse mechanisms underlying PLE in adolescence; hallucinatory experiences may be linked to inflammatory functions, while cannabis use may engage an alternative metabolic pathway related to increased energy demand and ketogenesis in inducing PLE. The limited sample of individuals with depression restricts the generalizability of these findings. Future research should explore whether various experiences and related metabolomic changes jointly predict the onset of psychoses and related disorders.
Localized release of muscle-generated BDNF regulates the initial formation of postsynaptic apparatus at neuromuscular synapses
Authors: Zhang Jinkai , Kwan Hiu-Lam Rachel , Chan Chi Bun , Lee Chi Wai 
Published: November 2024

AbstractGrowing evidence indicates that brain-derived neurotrophic factor (BDNF) is produced in contracting skeletal muscles and is secreted as a myokine that plays an important role in muscle metabolism. However, the involvement of muscle-generated BDNF and the regulation of its vesicular trafficking, localization, proteolytic processing, and spatially restricted release during the development of vertebrate neuromuscular junctions (NMJs) remain largely unknown. In this study, we first reported that BDNF is spatially associated with the actin-rich core domain of podosome-like structures (PLSs) at topologically complex acetylcholine receptor (AChR) clusters in cultured Xenopus muscle cells. The release of spatially localized BDNF is tightly controlled by activity-regulated mechanisms in a calcium-dependent manner. Live-cell time-lapse imaging further showed that BDNF-containing vesicles are transported to and captured at PLSs in both aneural and synaptic AChR clusters for spatially restricted release. Functionally, BDNF knockdown or furin-mediated endoproteolytic activity inhibition significantly suppresses aneural AChR cluster formation, which in turn affects synaptic AChR clustering induced by nerve innervation or agrin-coated beads. Lastly, skeletal muscle-specific BDNF knockout (MBKO) mice exhibit structural defects in the formation of aneural AChR clusters and their subsequent recruitment to nerve-induced synaptic AChR clusters during the initial stages of NMJ development in vivo. Together, this study demonstrated the regulatory roles of PLSs in the intracellular trafficking, spatial localization, and activity-dependent release of BDNF in muscle cells and revealed the involvement of muscle-generated BDNF and its proteolytic conversion in regulating the initial formation of aneural and synaptic AChR clusters during early NMJ development in vitro and in vivo.
Ultrafast complete dechlorination enabled by ferrous oxide/graphene oxide catalytic membranes via nanoconfinement advanced reduction
Authors: Xiao Qian , Li Wanbin , Xie Shujie , Wang Li , Tang Chuyang Y. 
Published: November 2024

AbstractChlorinated organic pollutants widely exist in aquatic environments and threaten human health. Catalytic approaches are proposed for their elimination, but sluggish degradation, incomplete dechlorination, and catalyst recovery remain extremely challenging. Here we show efficient dechlorination using ferrous oxide/graphene oxide catalytic membranes with strong nanoconfinement effects. Catalytic membranes are constructed by graphene oxide nanosheets with integrated ultrafine and monodisperse sub-5 nm nanoparticles through simple in-situ growth and filtration assembly. Density function theory simulation reveals that nanoconfinement effects remarkably reduce energy barriers of rate-limiting steps for iron (III)-sulfite complex dissociation to sulfite radicals and dichloroacetic acid degradation to monochloroacetic acid. Combining with nanoconfinement effects of enhancing reactants accessibility to catalysts and increasing catalyst-to-reactant ratios, the membrane achieves ultrafast and complete dechlorination of 180 µg L−1 dichloroacetic acid to chloride, with nearly 100% reduction efficiency within a record-breaking 3.9 ms, accompanied by six to seven orders of magnitude greater first-order rate constant of 51,000 min−1 than current catalysis. Meanwhile, the membranes exhibit quadrupled permeance of 48.6 L m−2 h−1 bar−1 as GO ones, because nanoparticles adjust membrane structure, chemical composition, and interlayer space. Moreover, the membranes show excellent stability over 20 cycles and universality for chlorinated organic pollutants at environmental concentrations.
Postoperative Auditory Progress in Cochlear-Implanted Children With Auditory Neuropathy
Authors: Yildirim Gökay Nuriye , Gündüz Bülent , Karamert Recep , Tutar Hakan 
Published: November 2024

Purpose:
This study aims to evaluate the effect of auditory neuropathy spectrum disorder (ANSD) on postoperative auditory perception and listening difficulties in pediatric cochlear implant (CI) recipients.

Method:

The Children's Auditory Perception Test (CAPT) assesses auditory perception skills, and the Children's Home Inventory of Listening Difficulties (CHILD) Scale evaluates daily listening difficulties. The study involved pediatric CI recipients (
n
= 40) aged between 5 and 7 years, with and without diagnosis of ANSD. The research ensured homogeneity across various factors, including chronological age, age at diagnosis, age at initial implantation, bilateral simultaneous surgery, etiologies of hearing loss, and family education level.

Results:

The findings have demonstrated that children without ANSD exhibited better performance in integrating visual–auditory stimuli and overall listening performance, distant sound source scores, and noisy environment scores (respectively
p
= .047,
p
= .001,
p
= .028, and
p
= .010). Additionally, children with better speech perception also have a better ability to integrate audiovisual stimuli (
p
= .005,
r
= .438).

Conclusions:
There are significant differences in postoperative listening skills and auditory perceptions between children with and without an ANSD who have CIs. Accordingly, children without an ANSD perform better.
A Qualitative Study of Psychiatric Patients’ Perceptions of Pharmacy Services in the Psychiatric Department
Authors: Rahajeng Bangunawati , Utami Pinasti , Kusumastiwi R.R. Tesaviani , Sari Prita Anggraini Kartika 
Published: November 2024

This study aims to determine patients’ perception of pharmacy services in the psychiatric polyclinic at PKU Muhammadiyah Gamping Hospital, Yogyakarta.
A descriptive qualitative technique was used in this investigation. The mental polyclinic patients’ experiences with the pharmacological services they received were shared. Open-ended questions about the patient’s knowledge of the medication, the objectives of therapy, the occurrence of side effects, the patient’s response to them, whether the patient received treatment-related information from the psychiatrist, whether the patient received information from the pharmacist about drugs, and whether the patient was satisfied with pharmacy services were used during the March–April 2023 interview process.
There were 39 participants with mental health issues in this study. Eleven respondents could name the type of medication given to them. Ten patients reported not receiving an explanation from the doctor about their therapy. After using the medication, some patients reported feeling comfortable. Some patients reported experiencing adverse effects like sleepiness, tremors, shortness of breath, and spotting. Eight patients who consulted pharmacists for medication showed patient recognition of pharmacists. Most patients were satisfied with pharmacists’ pharmaceutical services, but some demanded a more thorough explanation of their illness and alternative treatments.
Pharmaceutical services for psychiatry have been performed well according to patient perceptions. Several aspects still need to be improved.
Effects of Growth Hormone on Osteoarthritis Development
Authors: Sun Lin , Gang Xiaokun , Li Fei , Guo Weiying , Cui Mengzhao , Wang Guixia 
Published: November 2024

AbstractOsteoarthritis (OA), a chronic joint disease characterized by primary or secondary
degeneration of articular cartilage and bone dysplasia, is associated with various
risk factors and is the leading cause of musculoskeletal pain and disability,
severely impacting the quality of life. Growth hormone (GH), secreted by the
anterior pituitary gland, is essential in mediating the growth and development of
bone and cartilage. Reportedly, osteoarthritis increases, and the growth hormone
decreases with age. A negative correlation between GH and OA suggests that GH may be
related to the occurrence and development of OA. Considering that abnormal growth
hormone levels can lead to many diseases related to bone growth, we focus on the
relationship between GH and OA. In this review, we will explain the effects of GH on
the growth and deficiency of bone and cartilage based on the local pathological
changes of osteoarthritis. In addition, the potential feasibility of treating OA
with GH will be further explored and summarized.
Lymphatic Malformations: Review of Diagnosis and Management for the Interventional Radiologist
Authors: Lee Shimwoo , Luhar Aarti , Miller Joseph 
Published: November 2024

AbstractLymphatic malformations (LMs) arise from errors in lymphatic vascular development during embryogenesis and encompass an array of conditions that span from common cystic LMs to complex lymphatic anomalies (CLAs). Manifestations of LMs are wide-ranging, from clinically inconsequential to life-threatening. Proper diagnosis and management can be challenging and often benefit from an experienced multidisciplinary team. Cystic LMs are localized entities for which percutaneous sclerotherapy is the mainstay treatment. CLAs, on the other hand, are more diffuse in involvement and typically require multimodal therapy. With advances in the genetic understanding of LMs, targeted systemic therapies have been increasingly utilized with promising results. Thoracic duct interventions, both surgical and percutaneous, have a limited role in CLAs and should be approached cautiously to avoid significant complications. In this review, we discuss the genetic basis, imaging findings, and management options for LMs, with a particular focus on relevant interventional radiology techniques.
Sustainable supply chain management operations: does sustainable environmental disclosure matter for banks’ financial performance in Nigeria?
Authors: Chen Ding , Gummi Umar Muhammad , Ibrahim Mustapha , Tahir Fatima Alfa 
Published: November 2024

AbstractIn recent years, banks have incorporated sustainable development strategies to achieve competitiveness in the financial market. However, the primary concern for banks is the financial pressure to implement sustainable environmental practices. In addition, banks are obliged by different regulators to maintain standards in conducting their business and allocating funds. Previous studies examined the relationship between sustainability reporting, corporate social responsibility (CSR), and firms’ financial performance. Few empirical studies examined the impact of sustainable supply chain management (SSCM) operations on firm financial outcomes, yet the banking sector has been ignored in the analyses. To bridge this gap, we examine the dynamic effect of SSCM operations on deposit money banks’ (DMBs) financial performance. We selected seven banks in Nigeria with national, regional and international authorization and data spanning from 2005 to 2023. Based on the panel co-integration test and the Cross-sectional Dependence Autoregressive Distributed Lag model (CS-ARDL) model, we found that SSCM operations have a significant influence on the financial performance (market value and profitability) of the banks. Impliedly, banks’ SSCM operations and environmental consideration in the allocation of funds drive their corporate image and value. Integration of SSCM strategies for a sustainable environment can help enterprises/companies bridge information asymmetry among diverse stakeholders. We offer some policy suggestions in line with the empirical findings.
A globally optimized fault diagnosis model based on generative flow model for imbalanced data
Authors: Li Junxiong , Jiao Wenhua , Xiong Yudou , Cai Xiaoyi , Guo Changfang 
Published: November 2024

Abstract
In the actual scenario of fault diagnosis based on deep learning, the diagnosis accuracy is often affected by the lack of fault state data, so the processing of imbalanced data is always a significant challenge. generative adversarial networks (GAN) and denoising diffusion probability models (DDPM) are widely used for data augmentation. However, GAN often shows sensitivity and instability in the training process, and the sample generation speed of DDPM is slow due to the steps requiring multiple iterations–both of which are limiting factors. To solve these problems, we introduce the generative flow network with invertible 1 × 1 convolutions (GLOW) into fault diagnosis. The GLOW model is optimized by maximum likelihood estimation and does not require multiple iterations to generate samples, avoiding the problems faced by GAN and DDPM. In order to generate balanced data explicitly, we propose a condition GLOW (CGLOW) to provide class-balanced samples in real time throughout the framework. On the other hand, using the reversibility of CGLOW, we design an end-to-end fault diagnosis framework that is globally optimized to mitigate the decline in diagnostic accuracy caused by the separation of generation and diagnosis and simplify the steps of fault diagnosis. In addition, to accommodate the non-stationary characteristics of fault signals, we propose a new data transformation method to improve the feature mining ability of the model and the diagnostic accuracy. Finally, we conduct extensive experiments to validate the superiority of the proposed approach. The experimental results demonstrate that our method outperforms existing ones.
Local minimizers of the mass constrained problem for the mass-supercritical bi-harmonic Schrödinger equation
Authors: Han Fangyu , Gao Yuetian , Han Zeye 
Published: November 2024

Abstract
In this paper, we study the mass constrained problem for the mass-supercritical bi-harmonic Schrödinger equation with power nonlinearities in

R

N

(

N
⩾
1

), where the coefficients of Laplacian and bi-Laplacian have the same sign. First, we construct an unbounded open set

O

in H
2 that satisfies that

O

∪
{
0
}

is a star-shaped domain. Second, we prove the existence of minimizers on

O

∩
{
‖
u

‖
2
2

=
λ

for some fixed

λ
>
0
}

when the mass does not exceed a certain threshold and the coefficient of the Laplacian is suitably small, meanwhile, the explicit bounds of the Lagrange multiplier are also obtained. Finally, we prove the orbital stability of the local minimizer. This answers the open problem listed in Luo and Yang (2023 Sci. China Math.
66 1237–62). Combined with the existing literature, a systematic answer is given for the mass constrained problem of the arbitrary dimensional bi-harmonic Schrödinger equation with (critical, subcritical and supercritical) power nonlinearities, where the coefficients of Laplacian and bi-Laplacian can have the same or different sign.
Ex vivo validation of non-invasive phase correction for transspine focused ultrasound: model performance and target feasibility
Authors: Martin David , Xu Rui , Dressler Max , O’Reilly Meaghan A 
Published: November 2024

Abstract

Objective. To evaluate the feasibility of transspine focused ultrasound using simulation-based phase corrections from a CT-derived ray acoustics model. Approach. Bilateral transspine focusing was performed in ex vivo human vertebrae with a spine-specific ultrasound array. Ray acoustics-derived phase correction was compared to geometric focusing and a hydrophone-corrected gold standard. Planar hydrophone scans were recorded in the spinal canal and three metrics were calculated: target pressure, coronal and sagittal focal shift, and coronal and sagittal Sørensen–Dice similarity to the free-field. Post hoc analysis was performed in silico to assess the impact of windows between vertebrae on focal shift. Main results. Hydrophone correction reduced mean sagittal plane shift from 1.74 ± 0.82 mm to 1.40 ± 0.82 mm and mean coronal plane shift from 1.07 ± 0.63 mm to 0.54 ± 0.49 mm. Ray acoustics correction reduced mean sagittal plane and coronal plane shift to 1.63 ± 0.83 mm and 0.83 ± 0.60 mm, respectively. Hydrophone correction increased mean sagittal similarity from 0.48 ± 0.22 to 0.68 ± 0.19 and mean coronal similarity from 0.48 ± 0.23 to 0.70 ± 0.19. Ray acoustics correction increased mean sagittal and coronal similarity to 0.53 ± 0.25 and 0.55 ± 0.26, respectively. Target pressure was relatively unchanged across beamforming methods. In silico analysis found that, for some targets, unoccluded paths may have increased focal shift. Significance. Gold standard phase correction significantly reduced coronal shift and significantly increased sagittal and coronal Sørensen–Dice similarity (p < 0.05). Ray acoustics-derived phase correction reduced sagittal and coronal shift and increased sagittal and coronal similarity but did not achieve statistical significance. Across beamforming methods, mean focal shift was comparable to MRI resolution, suggesting that transspine focusing is possible with minimal correction in favourable targets. Future work will explore the mitigation of acoustic windows with anti-focus control points.
Nonlinear evolution of hydrodynamic instabilities seeded by the isolated internal defect in HDC capsules
Authors: Lei Zhu , Li Jun , Wang Lifeng , Chen Zhu , Li Jiwei , Zou Shiyang , Wu Junfeng , Liu Yunxing , Yan Zheng , Yang Guowei , He Xiantu 
Published: November 2024

Abstract
Achieving fusion ignition and higher gain requires substantial heating and compression of thermonuclear fuel. However, internal defects in the capsule can disrupt this process by seeding nonlinear hydrodynamic instabilities during implosion. We systematically analyze the evolution of isolated internal defects at various locations within a planar high-density carbon (HDC) capsule driven by x-ray radiation. Our results show that defect evolution varies significantly based on location due to the differing speeds of the shockwave and ablation front. Front-located defects are influenced by both the shockwave and the ablation front, leading to lateral disturbances and vortex traces as the shockwave passes through. This interaction causes an inverted density distribution, resulting in defects on the central axis evolving into spike-like structures. Mid-located defects encounter the shockwave before the ablation front, resulting in vorticity deposition and vortex pair formation, which interact with the ablation front in a positive feedback loop, enhancing nonlinear growth. Rear-located defects are reached by a rarefaction wave before the ablation front, causing the defects to accelerate ahead while the ablation front maintains a stable structure. Additionally, defects with varying initial disturbance amplitudes at the same position exhibited a certain degree of self-similarity in their evolution. These results provide crucial theoretical insights and numerical simulations for understanding the complex mechanisms by which shockwaves and ablation fronts influence defect evolution within HDC capsules.