bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computer-assisted EEG diagnostic review for idiopathic generalized epilepsy
Authors: Clarke Shannon , Karoly Pip , Nurse Ewan , Seneviratne Udaya , Taylor Janelle , Knight-Sadler Rory , Kerr Robert , Moore Braden , Hennessy Patrick , Mendis Dulini , Lim Claire , Miles Jake , Cook Mark , Freestone Dean , D’Souza Wendyl 
Published: June 2019

AbstractEpilepsy diagnosis can be costly, time-consuming and not uncommonly inaccurate. The reference standard diagnostic monitoring is continuous video-EEG monitoring, ideally capturing all events or concordant interictal discharges. Automating EEG data review would save time and resources, thus enabling more people to receive reference standard monitoring and also potentially herald a more quantitative approach to therapeutic outcomes. There is substantial research into automated detection of seizures and epileptic activity from EEG. However, automated detection software is not widely used in the clinic; and, despite numerous published algorithms, few methods have regulatory approval for detecting epileptic activity from EEG.This study reports on a deep learning algorithm for computer-assisted EEG review. Deep, convolutional neural networks were trained to detect epileptic discharges using a pre-existing dataset of over 6000 labelled events in a cohort of 103 patients with idiopathic generalized epilepsy (IGE). Patients underwent 24-hour ambulatory outpatient EEG, and all data was curated and confirmed independently by two epilepsy specialists (Seneviratne et al, 2016). The resulting automated detection algorithm was then used to review diagnostic scalp-EEG for seven patients (four with IGE and three with events mimicking seizures) to validate performance in a clinical setting.The automated detection algorithm showed state-of-the-art performance for detecting epileptic activity from clinical EEG, with mean sensitivity of >95% and corresponding mean false positive rate of 1 detection per minute. Importantly, diagnostic case studies showed that the automated detection algorithm reduced human review time by 80%-99%, without compromising event detection or diagnostic accuracy. The presented results demonstrate that computer-assisted review can increase the speed and accuracy of EEG assessment and has the potential to greatly improve therapeutic outcomes.
Molecular dynamics simulations and linear response theories jointly describe biphasic responses of myoglobin relaxation and reveal evolutionarily conserved frequent communicators
Authors: Huang Bang-Chieh , Yang Lee-Wei 
Published: June 2019

AbstractIn this study, we provide a time-dependent (td-) mechanical model, taking advantage of molecular dynamics (MD) simulations, quasiharmonic analysis of MD trajectories and td-linear response theories (td-LRT) to describe vibrational energy redistribution within the protein matrix. The theoretical description explains the observed biphasic responses of specific residues in myoglobin to CO-photolysis and photoexcitation on heme. The fast responses are found triggered by impulsive forces and propagated mainly by principal modes <40 cm-1. The predicted fast responses for individual atoms are then used to study signal propagation within protein matrix and signals are found to propagate ∼ 8 times faster across helices (4076 m/s) than within the helices, suggesting the importance of tertiary packing in proteins’ sensitivity to external perturbations. We further develop a method to integrate multiple intramolecular signal pathways and discover frequent “communicators”. These communicators are found evolutionarily conserved including those distant from the heme.
Heterogeneous expression of Pil3 pilus is critical for Streptococcus gallolyticus translocation across polarized colonic epithelial monolayers
Authors: Martins Mariana , du Merle Laurence , Trieu-Cuot Patrick , Dramsi Shaynoor 
Published: June 2019

ABSTRACTStreptococcus gallolyticus subspecies gallolyticus (Sgg) is an opportunistic pathogen responsible for septicaemia and endocarditis in elderly persons. Sgg is also a commensal of the human gastrointestinal tract. Here we demonstrate that Sgg strain UCN34 translocates across tight intestinal barriers in vitro in a Pil3-dependent manner. Confocal images of UCN34 passage across human colonic cells reveals that Sgg utilizes a paracellular pathway. Pil3 was previously shown to be expressed heterogeneously and WT UCN34 consists of about 90% of Pil3low and 10% of Pil3high cells. We found that both the Δpil3 mutant and the Pil3+ overexpressing variant could not translocate across Caco-2 and T84 barriers. Interestingly, combining live Δpil3 mutant cells with fixed Pil3+ variants in a 10:1 ratio (mimicking UCN34 WT population) allowed efficient translocation of the Δpil3 mutant. These experiments demonstrate that heterogeneous expression of Pil3 plays a key role in optimal translocation of Sgg across the intestinal barrier.ABSTRACT IMPORTANCEStreptococcus gallolyticus subsp. gallolyticus (Sgg) is an opportunistic pathogen responsible for septicemia and infective endocarditis in elderly persons. Sgg is a commensal of the rumen of herbivores and transmission to humans most probably occurs through the oral route. In this work, we have studied how this bacterium crosses the intestinal barrier using well-known in vitro models. Confocal microscopy images revealed that Sgg UCN34 can traverse the epithelial monolayer in between adjacent cells. We next showed that passage of Sgg from the apical to the basolateral compartment is dependent on the heterogenous expression of the Pil3 pilus at the bacterial surface. We hypothesize that Pil3high cocci adhere firmly to epithelial cells to activate transient opening of tight junctions thereby allowing the traversal of Pil3low bacteria.
Building supply chain risk resilience
Authors: Singh Nitya Prasad , Singh Shubham 
Published: June 2019

PurposeThe purpose of this paper is to examine how firms can develop business risk resilience from supply chain disruption events, by developing big data analytics (BDA) capabilities within their organization. The authors test whether BDA mediates the impact of institutional response to supply chain disruption events, and information technology infrastructure capabilities (ITICs), on firm’s ability to develop risk resilience from supply chain disruption events.Design/methodology/approachThe study is based on survey data collected from 225 firms, spread across several sectors in the USA and Europe. The respondents are primarily senior and middle management professionals who have experience within the information technology (IT) and supply chain domain. Validity and reliability analyses were performed using SPSS and AMOS; and covariance-based structural equation modeling was used to test the hypothesis.FindingsThe analysis reveals two significant findings. First, the authors observe that institutional experience with managing supply chain disruption events has a negative impact on firm’s ability to develop business risk resilience. However, if the organizations adopt BDA capabilities, it enables them to effectively utilize resident firm knowledge and develop supply chain risk resilience capacity. The results further suggest that BDA positively adds to an organization’s existing IT capabilities. The analysis shows that BDA mediates the impact of ITIC on the organization’s ability to develop risk resilience to supply chain disruption events.Originality/valueThis study is one of the few works that empirically validate the important role that BDA capabilities play in enabling firms develop business risk resilience from supply chain disruption events. The study further provides a counterpoint to the existing perspective within the supply chain risk management literature that institutional experience of managing past supply chain disruption events prepares the organization to deal with future disruption events. This paper adds to our understanding of how, by adopting BDA capabilities, firms can develop supply chain risk resilience from disruption events.
Organizational planning for quality management in the digital age
Authors: Behmer Falk Johannes , Jochem Roland 
Published: June 2019

Purpose
Quality managers today require a holistic, overreaching view on the organization and its goals in order to plan the quality management organization (QMO) effectively. The purpose of this paper is to present the concept of a web application that aims to support quality managers in organizational planning tasks. The basis for the implementation is a previously developed planning method that builds on Product and Technology Roadmapping as well as Quality Function Deployment. It supports the QMO’s strategic development in line with the organization’s overall strategy.

Design/methodology/approach
Based on previous research that systematically identified the requirements toward a suitable planning method and a consecutively designed framework, a web application was developed. This process followed agile software development approaches, including test-driven iteration cycles and validation through a case-based user trial.

Findings
Standardized quality criteria for software development together with identified requirements for a suitable planning method provided a specified guideline to develop a web application. This application enables quality managers to effectively deploy the previously developed planning method. It proved successful in an initial field trial and creates a basis for integrated, computer-aided QMO planning.

Originality/value
With an integrated planning method that was implemented through a web application, quality managers could be effectively supported in developing the QMO in line with the overall strategy. As organizational planning tasks are reoccurring but not day-to-day business, moderated workshops that use the web application as a guiding tool and enable quality managers to focus on delivering information inputs appear to be a highly promising approach.
Do multi-stakeholder initiatives make for better CSR?
Authors: Tanimoto Kanji 
Published: June 2019

PurposeThis paper aims to examine the significance and challenges of corporate social responsibility (CSR) initiatives organized by multi-stakeholders and to clarify the function of CSR initiatives: What is the significance of multi-stakeholder initiatives (MSIs)? What conditions are required for CSR initiatives to work satisfactorily? How do CSR standards function effectively in companies?Design/methodology/approachThe significance and challenges of multi-stakeholder CSR initiatives are clarified theoretically, based on previous literature from relevant research fields.FindingsMSIs are beyond the “dichotomy” of two traditional approaches to CSR, namely, voluntary vs mandatory. However MSIs do not automatically ensure good performance. We should discuss not only the legitimacy of MSIs but external monitoring and evaluation systems for responsible companies in the market, as well as organizational efforts to incorporate CSR standards into managerial processes.Social implicationsThis paper shows that an MSI is an important platform for establishing and promoting a CSR standard, and further that market maturity and stakeholder engagement are required to make CSR work.Originality/valueThe study explains that ceremonial compliance with CSR standards may be inevitable even where the legitimacy of an MSI is secured, and that we should recognize that monitoring and sanction systems in the market and an organizational approach to the incorporation of CSR in management practices are required.
Diamond enriched lamination and winding insulation for electrical machines
Authors: Szucs Aron , Kolondzovski Zlatko , Westerlund Jan , Vahala Juha 
Published: June 2019

Purpose
The thermal management of electrical insulations poses a challenge in electrical devices as electrical insulators are also thermal insulators. Diamond is the best solid electrical insulator and thermal conductor. This can lead to a paradigm change for electrical machine winding and lamination insulation design and thermal management. The paper introduces these techniques and discusses its effect for the design of electrical machines and its potential consequences for electromagnetic analysis, for example, in multi-physics modelling. The diamond winding insulation is patent-pending, but the diamond enriched lamination insulation is published for the benefit of the scientific community.

Design/methodology/approach
The windings of electrical machines are insulated to avoid contact between the coil and other conductive components, for example, the stator core. The principle of using mica tape and resin impregnation has not changed for a century and is well established to produce main insulation on a complex conductor shape and size. These insulations have poor heat-conducting properties. Similarly, the insulation of laminated steel sheets comprising the stator and rotor restrict heat flow. Diamond-based insulation provides a new path. Increased thermal conductivity means reduced temperature rise and the reduced thermal time constants in multi-physics simulations and system analysis.

Findings
The largest benefit of a diamond-based core insulation is in electrical machines in which the losses are conducted axially to the coolant. These are machines with radial ducts and effective cooling in the end regions. The main benefit will be in reducing the number of radial ducts that positively affect the size, production costs and the copper losses of the machine. The increased thermal conductivity of the diamond insulation system will reduce the thermal constants noticeably. These will affect system behavior and the corresponding simulation methods.

Originality/value
Diamond insulation can lead to a paradigm change for electrical machine winding and lamination insulation design and thermal management. It might also lead to new modeling requirements in system analysis.
Do five-star hotel managers know their customers’ priorities? An AHP-Prioritised scorecard study
Authors: Ishizaka Alessio , Quintano Alfred , Labib Ashraf , Apostolakis Alexandros 
Published: June 2019

PurposeRegular surveys by the Malta Hotels & Restaurants Association indicate a substantial improvement in the financial performance of five-star hotels in Malta in recent years. Therefore, the purpose of this paper is to investigate if this positive performance is primarily due to customer centricity by management.Design/methodology/approachThe assessment is based on the findings of a quantitative study that compared the results of a demand side (customer survey) with those of a supply side (management survey). In total, 24 decision-choice criteria were framed within the four perspectives (financial, customer, internal process and employee learning/growth) of the balanced scorecard. Actual and potential customers of five-star hotels and hotel managers were asked to rank the decision-choice criteria and the balanced scorecard perspectives. The multi-criteria decision analysis was carried out by means of the AHP.FindingsThe study showed that managers in the five-star hospitality sector in Malta are in harmony with customer expectations given the strong positive correlation between the results of the customer and management surveys.Research limitations/implicationsThis research is limited to the island of Malta but can be easily replicated for other touristic destinations.Practical implicationsThis study has implication for hospitality customers, hotel managers and policy makers to help them to identify weak areas of hotel performance and improve them.Originality/valueThe paper has developed a Prioritised scorecard, a new hybrid balanced scorecard and AHP. Targets are therefore prioritised, which allow a better allocation of scarce resources.
Housing markets’ linkage between China and Taiwan
Authors: Chien Mei-Se , Lee Neng-Huei , Cheng Chih-Yang 
Published: June 2019

PurposeThis paper aims to examine the linkage of regional housing markets between Taiwan and China as increasing economic integration.Design/methodology/approachTwo time-varying estimations of cointegration tests, Gregory and Hansen (1996) cointegration test with structural break and the recursive coefficients of cointegration (Hansen and Johansen, 1993) are applied to trace the possible dynamic linkage of cross-border regional housing prices between Taiwan and China.FindingsFirst, the estimating results of the long-run relationships show that increasing housing prices in Beijing and Shanghai decrease Taipei’s house prices, while Shenzhen and Chengdu have converse effects. The technologies’ levels of Taiwanese industries surrounding the cities in China will affect the direction of the linkage of regional housing prices between the two economies. Second, in light of causalities of these five housing prices’ changes, Beijing and Shanghai lead Taipei and Shanghai leads Chengdu, which, in turn, leads Shenzhen. Finally, the results of time-varying cointegration tests show that some critical economic and political incidents changed the linkages of housing prices between Taipei and the four cities in China.Originality/valueAlthough some empirical works examined the linkages between cross-border house prices in Europe and the USA, study has looked at the linkages of cross-border housing prices between Taiwan and China. This is an interesting topic insofar as house price integration has implications for wealth effects that feed into consumer expenditure in both Taiwan and China. The empirical evidence overall displays the existence of the integration of regional housing markets between Taiwan and China. For the longer-term future, increasing economic integration between China and other Asia countries will result in greater and more diversified cross-border housing markets and pools of investors.
On sparsity of eigenportfolios to reduce transaction cost
Authors: Xiong Anqi , Akansu Ali N. 
Published: June 2019

PurposeTransaction cost becomes significant when one holds many securities in a large portfolio where capital allocations are frequently rebalanced due to variations in non-stationary statistical characteristics of the asset returns. The purpose of this paper is to employ a sparsing method to sparse the eigenportfolios, so that the transaction cost can be reduced and without any loss of its performance.Design/methodology/approachIn this paper, the authors have designed pdf-optimized mid-tread Lloyd-Max quantizers based on the distribution of each eigenportfolio, and then employed them to sparse the eigenportfolios, so those small size orders may usually be ignored (sparsed), as the result, the trading costs have been reduced.FindingsThe authors find that the sparsing technique addressed in this paper is methodic, easy to implement for large size portfolios and it offers significant reduction in transaction cost without any loss of performance.Originality/valueIn this paper, the authors investigated the performance the sparsed eigenportfolios of stock returns in S&P500 Index. It is shown that the sparsing method is simple to implement and it provides high levels of sparsity without causing PNL loss. Therefore, transaction cost of managing a large size portfolio is reduced by employing such an efficient sparsity method.
Governance structure and public health provision
Authors: Sheard David John , Clydesdale Gregory , Maclean Gillis 
Published: June 2019

Purpose
A key question in the provision of public health concerns how that provision is governed. The purpose of this paper is to examine the governance structure of a public health board and its perceived impact on the efficacy of clinical operations.

Design/methodology/approach
Structural issues examined the level of centralisation and public participation, and whether governance should occur through elected boards or appointed managers. These issues were examined through multiple lenses. First was the intention of the structure, examining the issues identified by parliament when the new structure was created. Second, the activities of the board were examined through an analysis of board meetings. Finally, hospital clinicians were surveyed through semi-structured interviews with both quantitative and qualitative questioning.

Findings
A contradiction was revealed between intention, perception and actual activities. This raises concerns over whether the public are significantly informed to elect the best-skilled appointees to governance positions.

Practical implications
This research holds implications for selecting governance structures of public health providers.

Originality/value
Few studies have looked at the role of a publicly elected healthcare governance structure from the perspective of the clinicians. Hence, this study contributes to the literature on healthcare structure and its impact on clinical operations, by including a clinician’s perspective. However, this paper goes beyond the survey and also considers the intention of the structure as proposed by parliament, and board activities or what the board actually does. This enables a comparison of intention with outcomes and perception of those outcomes.
Performance of hybrid fibres on mechanical properties of self-compacting concrete at elevated temperature
Authors: B.P. Sachin , Suresh N. 
Published: June 2019

Purpose
The present experimental investigation attempts to study the behaviour of hybrid fibre-reinforced self-compacting concrete (HFSCC) subjected to elevated temperature. The purpose of this study is to find out the performance of hybrid fibres of 0.5 per cent by volume of concrete (out of which 75 per cent are steel fibres and 25 per cent, polypropylene fibres). Reinforced beams were casted and tested for the flexural load-carrying capacity, and comparisons were made with the load-carrying capacity of reinforced beams without the inclusion of fibres.

Design/methodology/approach
The study includes 60 concrete cubes of 150 mm and 60 beams of 150 × 150 × 1,100 mm reinforced with minimum tension reinforcement according to IS 456-2000. The specimens were subjected to elevated temperature from 100°C to 500°C with an interval of 100°C for 2 h. The residual compressive strength and the load-carrying capacity of beams for 5-mm deflection were measured. Parameters such as load at first crack, width and length of cracks developed on the beam during the application of load were also studied.

Findings
The result shows that for self-compacting concrete without fibres (SCCWOF), there is a gain in compressive strength between 200°C and 300°C, beyond which the strength decreases. For HFSCC, the gain in strength is between 300°C and 400°C, and thereafter the strength gets reduced. The load-carrying capacity of beams reduces with an increase in temperature. An increase in load-carrying capacity (up to 40.7 per cent) for HFSCC beams is observed when compared to SCCWOF beams at 500°C.

Originality/value
Better performance was observed with the usage of fibres when the specimens were subjected to elevated temperatures.