bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute intercostal pulmonary hernia following uniportal video-assisted thoracoscopic surgery for pulmonary conditions
Authors: Huang Shaoqing , Song Xu , Shi Qiang , Li Jie 
Published: November 2024

Abstract

Intercostal pulmonary hernia is an uncommon condition characterized by the protrusion of lung parenchyma through a compromised or defective chest wall into the thoracic cavity. The etiologies of pulmonary hernia can be categorized as traumatic, post-thoracotomy, and spontaneous occurrences. Treatment modalities for pulmonary hernia are classified into conservative management and surgical intervention. We present a case of acute intercostal pulmonary hernia in a patient following wedge resection of the left upper lobe via uniportal video-assisted thoracoscopic surgery, which was successfully addressed through manual reinsertion.
Three-dimensional evaluation of articular disc position and other temporomandibular joint morphology among Chinese patients with temporomandibular disorders: A retrospective MRI study
Authors: OSAMA ALMUSTAFA , Musa Mazen , zheng Cheng Dong , Zhang Hai Juan , Ren Yu Han , Wang Shuang 
Published: November 2024

Abstract

Background
The etiology and pathophysiology of temporomandibular disorders (TMDs), particularly the internal derangement of the joint, remain unclear. Accordingly, this study aimed to investigate the discal space changes, condylar position, and distance of disc displacement that occur in patients with temporomandibular disorder (TMD) and to explore joint space dimensions correlation to other factors such as age, sex, and distance of disc displacement.
Methods
A total of 130 patients (260 joints) were included in this cross-sectional study. The magnetic resonance imaging (MRI) of each patient was used to evaluate the temporomandibular joint (TMJ) discal space dimensions in the coronal and sagittal sections, and the distance of disc displacement. One-way ANOVA and Independent sample t-test were used for the normally distributed variables, and Kruskal-Wallis, Mann-Whitney u test were used for non-normally distributed variables. Bivariate correlation was conducted using spearman correlation coefficients to investigate the relation between age, disc position, and joint space dimensions.
Results
Among the sagittal spaces, the central joint space (CJS) was significantly larger on both sides (p < 0.001). When comparing joint spaces among sexes, the right side anterior joint space (AJS) was significantly greater in females (p = 0.006), while the left side medial and lateral joint spaces (MJS and LJS) were greater in males (p = 0.037 and 0.026, respectively). Discal space dimensions showed to be narrower in patients younger than 25 years, particularly for the central and medial discal spaces (p = < 0.001). The results of the bivariate analysis revealed a significant moderate to weak positive correlation between the age, AJS, CJS, and MJS in anterior disc displacement with reduction ADDWR (𝑟-2. = 0.408, 0.537, 0,287, respectively). Likewise, correlation between age and MJS showed weak correlation in anterior disc displacement without reduction ADDWoR (𝑟-2. = -0.253).
Conclusion
The central joint space is the largest among the other spaces. There are significant differences in joint space dimensions between sexes and age groups. Females have larger anterior joint spaces, whereas males present larger medial and lateral joint spaces. Additionally, younger individuals present narrower discal spaces, with age correlating moderately to weakly with joint space dimensions in cases of anterior disc displacement.
Transcriptomic Analysis of Identical Twins with Different Onset Ages of Adrenoleukodystrophy
Authors: Su Qiuyu , Chen Yinglian , Fu Chuhua , Zhang Yonghui , Zhang Yan , Cao Ying , Wang Xinggang , Zeng Zhiming , Liu Chen , Yang Zhao , Yin Changlin , Tan Liang 
Published: November 2024

Abstract

Adrenoleukodystrophy (ALD) is a rare X-linked neurogenetic disease caused by mutations in the ABCD1 gene. Currently, the molecular mechanisms underlying the onset and severity of ALD still remain unclear. Therefore, the aim of this paper is to mine information on candidate genes associated with onset and severity of ALD by transcriptome sequencing of whole blood samples from monozygotic twin families with ALD disease. The identifying of differentially expressed genes (DEGs), set theory analysis, gene enrichment analysis, and classification statistics of expression trend had been executed to identify potential candidate genes inducing the onset and severity of ALD in patients. And, eight ALD patients, which constituted by two normal children, two ALD child twins, twins’ mother, twins’ adult uncle with ALD, twins’ grandmother, and a normal adult had been used. In the present, five distinct sets of differentially expressed genes (DEGs) were identified via using whole blood samples from a family of identical twins with different onset ages and ABCD1 exon 2 deletion. Then, 39 DEGs of A∩B∩C-D and A∩B-D as well as 425 DEGs of C∩E had been considered as relating genes with the onset and severity of ALD. Especially, C4BPA, TPBG, CEP112, CHST15, SMAD1, IL-26, and LRRC69 had shown more important than others about ALD onset. Meanwhile, KEGG and GO enrichment further suggested the role of Ca2+ homeostasis and plasma membrane for ALD onset and severity. Finally, expression pattern analysis further demonstrated the pivotal role of the selected DEG sets. The information on candidate genes of this research had been considered as the crucial for preliminarily exploring the molecular mechanisms relating to the onset and severity of ALD, which offered novel insights and research directions for mitigating and treating the development of ALD.
Effectiveness of Virtual Environment Exercises on Physical Performance
Authors: Bavlı Özhan 
Published: November 2024

Abstract

Background
Virtual environment exercises are becoming more and more popular. Virtual environmental activities, which are used for different purposes in many areas, are quite new in the field of sports and need study findings.
Methods
The purpose of this study was to investigate the effects of 8 weeks of virtual reality (VR) and field-based fitness exercises on the performance characteristics of young individuals. Thirty participants, with an average age of 19.7 ± 1.3 years and who had not previously engaged in fitness exercises, volunteered for the study. The participants were randomly assigned to either a fitness exercise group or a virtual exercise group. Measurements of height, weight, static balance, flexibility, sit-up, plank performance, standing long jump, and leg strength were taken before and after the intervention. The data were analyzed via analysis software.
Results
The findings of the study revealed that all the values of the measured performance characteristics changed significantly in comparison with those in the preintervention phase. A comparison of these variables revealed that, in comparison with VR participants, participants exposed to fitness training improved their flexibility, long jump, BMI and leg press. On the other hand, the VR group demonstrated significantly greater improvement in balance performance than did the fitness group.
Conclusions
On the basis of these findings, VR-based exercise interventions may be useful in young people to increase balance more effectively than traditional fitness training for leg strength flexibility and long jump performance.
Child Cariogenic Diet and Parental Oral Health Literacy Level Between American and Brazilian Families
Authors: Menoncin Bruna Leticia Vessoni , Crema Aline Fabris de Araújo , de Menezes José Vitor Nogara Borges , Crispim Sandra Patrícia , Ferreira Fernanda de Morais , Zandoná Andrea Ferreira , Fraiz Fabian Calixto 
Published: November 2024

Abstract

Background: To comparethe cariogenic diets of children and parental OHL levels between American and Brazilian families.
Methods: Participating in this cross-sectional study were the parents/guardians of 946 children aged 2 to 5, Brazilian parents of children. There were 672 Brazilian parents of Brazilian children (BB), 203 American parents of American children (AA) and 61 Brazilian parents of American children (BA). A self-administered questionnaire about sociodemographic aspects and children’s oral health conditions was administered. Food practices were analyzed using a specific questionnaire. The parental mealtime action scale (PMAS) scores for daily fruit and vegetable availability, the snacks consumption model, and the snacks limit were collected. Parental OHL levels were assessed by the Oral Health Literacy Adult Questionnaire (OHL-AQ). Multiple comparison tests with the Kruskal‒Wallis post hoc test and Bonferroni correction were used for numerical variable analysis. For categorical variables, chi-square tests were performed.
Results: The AA and BA groups had more training in healthcare, more work in health-related areas and were more likely to be in a stable union when married than the BB group. Children of group AA or BA consumed more cariogenic food than those of BB group. The daily fruit and vegetable availability was greater in the AA group than in the other groups. Compared with those of BB, the snake modeling domain and snack limits of AA and BA were greater. The OHL of BA was greater than that of BB and was more similar to that of AA.
Conclusion: American children of Brazilian parents are closer to the eating habits of American children of American parents than to Brazilian children of Brazilian parents.
The incidence and risk factors for radiation pneumonia in anaplastic lymphoma kinase- positive non-small cell lung cancer patients treated with thoracic radiotherapy and simultaneous anaplastic lymphoma kinase tyrosine kinase inhibitor
Authors: Chen Feihu , Liu Haoyu , Jing Xuquan , Yang Zhengqiang , Zhu Hui 
Published: November 2024

Abstract

Background:
Anaplastic lymphoma kinase tyrosine kinase inhibitor(ALK-TKI) is a first-line treatment regimen for patients with advanced non-small cell lung cancer harboring anaplastic lymphoma kinase-positive. For non-small cell lung cancer patients with slow progression, thoracic radiotherapy can provide significant local control and survival benefits as an effective local consolidation therapy. Radiation pneumonia, one of the typical adverse reactions to radiation therapy, has not yet been reported in studies on the incidence of radiation pneumonia when ALK is combined with thoracic radiotherapy. Therefore, in this study, we aimed to evaluate the incidence and risk factors for radiation pneumonia in such patients and provide a reference for clinical practice.
Patients and methods: All medical records of patients with NSCLC who had ALK fusion between January 2016 and May 2023 at Shandong Cancer Hospital and Institute were reviewed using an institutional query system. All patients underwent intensity-modulated radiotherapy and 3-dimensional conformal radiation therapy with photon therapy. Radiation pneumonia was diagnosed via computed tomography and was classified according to the RTOG toxicity scoring system. The risk factors for radiation pneumonia were identified using univariate and multivariate analyses. The Kaplan–Meier method calculates progression-free survival (PFS) and overall survival (OS).
Results: Ultimately, 39 patients were included; 14 (35.8%) had grade 2 or above radiation pneumonia, and 6 out of 39 patients (12.8%) had grade 3 or above radiation pneumonia. The median time interval between the onset of radiation pneumonia and thoracic radiotherapy was 1.7 months. In univariate analysis, V20 ≥ 20.23%, V5≥35.63%, and PTV-volume ≥ 223.05 cm3 were associated with the occurrence of RP. In the multivariate analysis, V20 ≥ 20.23% and PTV-volume ≥ 223.05 cm3 was considered an independent predictor of radiation pneumonia occurrence. Crizotinib is also a risk factor for radiation pneumonia. The mPFS of all patients was 27.7 months. The mOS of all patients was 49.3 months.
Conclusions: In summary, our study reports for the first time that the incidence of grade 2 or more severe radiation pneumonia is slightly higher in patients receiving combined treatment with thoracic radiotherapy and anaplastic lymphoma kinase tyrosine kinase inhibitors. Simultaneously, whole-lung V20 and PTV volume are risk factors for radiation pneumonia.
Inhibition of Esophageal Squamous Cell Carcinoma Progression by MIR210HG and Activation of the P53 Signaling Pathway to Promote Apoptosis and Autophagy
Authors: Wang Jianyu , Zhang Zhenhu , Song Liang , Liu Xiangyan , He Xiaopeng 
Published: November 2024

Abstract

Background: Esophageal squamous cell carcinoma (ESCC) stands among the frequently occurring malignancies. The lack of efficient early detection methods and therapeutic approaches leads to a high mortality rate for ESCC. The long noncoding RNA MIR210HG is strongly related to various malignant tumors. However, its involvement in ESCC remains unexplored. Thus, this investigation aimed to assess the involvement of MIR210HG in ESCC development.
Methods: The MIR210HG expression was analyzed in numerous tumor types through pan-cancer analysis of The Cancer Genome Atlas(TCGA) database. This research investigated the MIR210HG role in the survival and prognosis of individuals with ESCC. The biological functions of MIR210HG were examined by enrichment analyses, including GO, GSEA, and KEGG. Moreover, drug sensitivity, immune cell infiltration, tumor microenvironment (TME) characteristics, and immune checkpoint expression levels associated with MIR210HG were explored. To get more insight into the connection between MIR210HG and ESCC, we assessed related gene and protein expression using Western blotting and qRT-PCR. To evaluate the proliferation, invasion, migration, apoptosis, and autophagy of ESCC cells, various techniques were employed, including EdU proliferation tests, Monodansylcadaverine(MDC) staining, wound healing assays, cell colony formation, transwell assays, flow cytometry, and an established xenograft mouse model.
Results: MIR210HG exhibited low expression levels in ESCC. High expression of MIR210HG correlated with a higher survival rate among patients. The elevated expression of MIR210HG hindered the ESCC cell's ability to proliferate, invade, and migrate, both in vivo and in vitro settings. Furthermore, a positive correlation between MIR210HG and the P53 signaling pathway was observed, which could affect autophagy and apoptosis in ESCC cells.
Conclusion: MIR210HG emerges as a pivotal gene in ESCC, influencing both the immunity and prognosis of patients. Moreover, it may affect autophagy and apoptosis via the P53 signaling pathway. Overall, these outcomes present novel ideas for ESCC treatment.
The CT phenotype of pulmonary immune-infiltration in patients with gastrointestinal cancers received CAR T-cell treatment
Authors: Liu Yiting , Chen Xiaojie , Ma Mingyang , He Meng , Li Jiazheng , Shen Lin , Qi Changsong , Tang Lei 
Published: November 2024

Abstract

Background To explore the chest CT signs of gastrointestinal cancer patients treated with CLDN18.2- specific CAR T-cell therapy, then categorize the CAR-T-PIE signs and elucidate the biological mechanisms.
Methods This retrospective study enrolled 96 patients from clinical trial (NCT03874897). Baseline and post-therapy chest CT, cytological indicators (IL-2, IL-6, IL-8, IL-10, IL-15) were assessed. The chest CT signs were classified into different types based on the degree of exudative and interstitial alterations correlated with immune enrichment. Wilcoxon test was used to assess correlations between CT findings and clinical parameters.
Results 31 patients developed CAR-T-PIE signs on chest CT, and three distinct pulmonary immune-infiltration patterns were identified. 3 patients were identified as Type 1 with imaging findings of exudative and interstitial changes around lung metastases. Exudative and interstitial changes were defined as Type 2, were diagnosed in 6 patients with lung metastases and 14 patients without lung metastases respectively. Lymphangitic carcinomatosis was observed in 2 patients, and classified as Type 3. The median overall survival (OS) with pulmonary immune-enrichment (Type 1-2) was significantly better than for those with negative CT findings or lymphangitic carcinomatosis (Type 3), with a median OS of 247 days (95% CI: 214.9, 277.1) versus 158 days (95% CI: 66.6, 177.4) (p=.043).
Conclusion CAR-T-PIE occurs about 1.9 weeks after infusion (2d~28d), with distinct CT phenotypes that correlate with treatment response and prognosis. The presence of pseudoprogression and immune pneumonia have the potential in serving as markers of effective therapy, while lymphangitic carcinomatosis indicate negative prognosis.
The exploration of factors correlated with Non-suicidal Self-injury in adolescents
Authors: Su Yi , Li Qiongwei 
Published: November 2024

Abstract

Adolescence is a crucial period of growth and development, and about 19.5% of children and adolescents suffered from non-suicidal self-injury (NSSI) worldwide. NSSI can lead to physical and psychological consequences, including an increased risk of suicidal behavior. To address this issue, public health interventions are urgently needed for NSSI prevention, early intervention, and mental health support. Our study aims to understand self-injurious behaviors in secondary school students, their incidence, types, causes, and influencing factors. This will help prevent and correct such behaviors. This study recruited 1770 adolescents in China. Data was collected through self-report questionnaires and several scales. Clinician-rated severity of non-suicidal self-injury was also used to assess NSSI behaviors. Multinomial logistic regression models were utilized to estimate the association between risk factors and NSSI. The study found that a significant proportion of adolescents (18.4%) engage in NSSI for various reasons, including to relieve negative emotions and to relax. The results indicated that early life trauma and poor emotional regulation are risk factors for NSSI, while positive social support (P < 0.001, t = 6.811) and resilience (P < 0.001, t = 9.459) have a protective effect. Additionally, sleeplessness (P < 0.001, t = 10.751) was found to be associated with NSSI. Our study suggests childhood trauma may cause emotion regulation issues, leading to emotional problems and maladaptive coping. Low resilience exacerbates these issues, but positive social support protects adolescents. These findings have implications for mental health interventions and prevention efforts.
Successful recanalization of a four-year-old long segment chronically occluded internal carotid artery (COICA) in a retrograde fashion and by a full co-axial support system.
Authors: Pandey Sajan , Yang Wen Hao , Li Lei , Zhang Quan Bin 
Published: November 2024

Abstract

Chronically occluded internal carotid artery, particularly refractory to the present medical and surgical treatment, carries a high risk of ischemic sequelae due to perfusion mismatch. The authors share a successful recanalization treatment detail of a symptomatic 72-year-old male patient who failed medical and surgical treatment for a chronically occluded long segment of the internal carotid artery for four years. The author focuses on the technical pearls of the novel full co-axial support system to recanalize the chronically occluded long internal carotid arterial segment.
Personalized Screening Tool for Early Detection of Sarcopenia in Stroke Patients: A Machine Learning-Based Comparative Study
Authors: Yan Huan , Li Juan , Li Yujie , Xian Lihong , Tang Huan , Zhao Xuejiao , Lu Ting 
Published: November 2024

Abstract

Background Sarcopenia often occurs in stroke patients and contributes to worse recovery and a higher risk of death. There is no standardized tool for screening sarcopenia in stroke patients. The objective of this study is to explore the factors influencing sarcopenia in stroke patients, develop a risk prediction model, and evaluate its predictive accuracy. Methods Demographic and clinical characteristics of 794 stroke patients were collected. LASSO regression analysis was used for variable selection, and the selected variables were analyzed using multivariate regression. Logistic Regression (LR), Random Forest (RF), and XGBoost were used to construct prediction models, with the optimal model selected for external validation. Bootstrap resampling was used for internal validation of the training cohort, and another 159 stroke patients were collected for external validation. The performance of models was evaluated using the AUC, calibration curve, and Decision Curve Analysis (DCA). Results Based on LASSO and multivariate logistic regression analysis, seven variables were selected. The AUC value for the LR model was 0.805, surpassing that of the RF model (0.796) and the XGBoost model (0.780). The LR model also outperformed RF and XGBoost in terms of accuracy, precision, recall, specificity, and F1-score. In external validation, the LR model achieved an AUC of 0.816, and the calibration curve along with the DCA curve demonstrated that the model has nice accuracy and clinical applicability. Conclusions In this study, we developed a model and presented it as a nomogram to detect the risk of sarcopenia in stroke patients, and such early screening may benefit these patients.
Efficacy of Advanced Cleaning Approaches in 3D Mandibular Molar Models: A Laboratory Study
Authors: Tiscareño Alissa , Ortolani-Seltenerich P.S. , Ramírez-Muñoz Ana , Pérez-Ron Omar , S Pedro M. Mendez , Leal-Moya Carmen , Vieira Gaya C.S. , Pérez Alejandro R. 
Published: November 2024

Abstract

Purpose: This study aimed to evaluate the efficacy of cleaning in minimally shaped mesial and oval distal canals of 3D models of mandibular molars, focusing on positive pressure irrigation, wireless and conventional passive ultrasonic irrigation (PUI), and diode laser (DL) at 980 nm.
Methods: Forty-four replicas of natural mandibular molars were divided into four groups of eleven 3D resin models with apical size 25/.04 mesial (n=22) and 35/.04 oval distal canals (n=11) to evaluate different irrigation methods. Each root canal was uniformly filled with an artificial hydrogel to simulate a biofilm mixture. Following this preparation, the specified irrigation techniques were applied to the respective groups. Quantitative evaluations of pre- and post-irrigation images were performed to assess the efficiency of tissue removal along the entire length of the canal and in the apical, middle, and coronal thirds.
Results: The findings revealed no significant differences in the initial amount of tissue between the samples, indicating uniform filling. In the apical region of mesial canals, conventional PUI showed the highest cleaning efficiency (14.1% residual tissue), significantly outperforming the other methods (p<0.05). Cordless PUI and DL also surpassed positive pressure irrigation, leaving 30.4% and 29.3% residual tissue, respectively, compared to 42.2% with positive pressure. In the middle third, all methods tested performed better than needle irrigation (p<0.05), but there were no significant differences in the coronal third or over the full canal length. Distal oval canals showed no significant differences in cleaning effectiveness among methods.
Conclusions: Although no single method was superior in full canal length, supplementary techniques such as PUI and DL offer potential benefits over conventional irrigation methods, particularly in the apical third of the canal.
Clinical Relevance: Complementary approaches such as conventional PUI and diode laser at 980 nm showed superior cleaning efficiency, particularly in the apical third. These results suggest their integration could improve cleaning effectiveness in minimally instrumented mesial canals.