bluuebunny/crossref_metadata_2025_split huggingface dataset:
NAVA—synchronized compared to nonsynchronized noninvasive ventilation for apnea, bradycardia, and desaturation events in VLBW infants
Authors: Tabacaru Christa R. , Moores Russell R. , Khoury Joseph , Rozycki Henry J. 
Published: August 2019

ABSTRACTNeurally adjusted ventilatory assistance (NAVA) can overcome technical difficulties with synchronizing noninvasive ventilation breaths with the patient, a modality often used in very low birthweight infants (VLBW) with apnea of prematurity (AOP). This study is a retrospective single‐center investigation into whether NAVA‐synchronized noninvasive (niNAVA) ventilation is better than nonsynchronized (nasal intermittent positive pressure ventilation [nIPPV]) for symptomatic apnea in VLBW infants. Nursing records of apnea, bradycardia, and/or desaturations were abstracted from the electronic medical records of 108 VLBW infants admitted to the neonatal intensive care unit (NICU) from 2015 to 2017 who received either of the two modalities, 61 epochs of niNAVA totaling 488 days and 103 epochs of nIPPV totaling 886.5 days. niNAVA was associated with a significant reduction in the number of isolated bradycardic events/day (0.48 ± 0.14 vs 1.35 ± 0.27; P = .019) and overall bradycardias/day (2.42 ± 0.47 vs 4.02 ± 0.53; P = .042) and there were more epochs with no events with niNAVA compared with nIPPV (23.0% vs 6.8%; P = .004). These results justify a prospective trial of NAVA‐synchronized noninvasive ventilation for VLBW infants with caffeine‐resistant AOP.
Central sleep apnea in children with obstructive sleep apnea syndrome and improvement following adenotonsillectomy
Authors: Del‐Río Camacho Genoveva , Medina Castillo Lucía , Rodríguez‐Catalán Jesús , Soto Insuga Victor , Gómez García Teresa 
Published: August 2019

AbstractBackgroundAlthough the pathogenesis of central and obstructive events seems to be different, these two entities may somehow be related. We aimed to determine whether, as reported in previous research, the number of central sleep apnea (CSA) cases in a population of children with obstructive sleep apnea syndrome (OSAS) was greater than in patients without obstructive events, and if CSA worsens with increasing OSAS severity. As a second objective, we analyzed changes in central apnea index (CAI) after adenotonsillar surgery compared to changes when no surgery has been performed.MethodsWe retrospectively reviewed nocturnal polysomnography (PSG) data from children between 1 and 14 years of age with no neurological conditions or syndromes. Patients with CAI values greater than 5 per hour were diagnosed as having CSA. Improvements of greater than 50% in CAI on repeat PSG were considered to represent a real change.ResultsData were available from 1279 PSG studies, resulting in 72 children with a CAI greater than 5 per hour (5.6%). Patients with OSAS showed a higher CAI (2.16) compared with those without OSAS (1.17), and this correlation increased with higher degrees of obstructive apnea severity. When adenotonsillectomy was performed due to OSAS, the CAI decreased by 1.37. The average decrease in PSG values was only 0.38 in cases where no surgery was performed.ConclusionThe results of this study suggest that although CSA is perceived to be mostly associated with central nervous system ventilatory control, there may be a connection with airway obstruction and in children with CSA and OSA diagnosis adenotonsillectomy may improve both conditions.
Assessment of protein assembly prediction in CASP13
Authors: Guzenko Dmytro , Lafita Aleix , Monastyrskyy Bohdan , Kryshtafovych Andriy , Duarte Jose M. 
Published: August 2019

AbstractWe present the assembly category assessment in the 13th edition of the CASP community‐wide experiment. For the second time, protein assemblies constitute an independent assessment category. Compared to the last edition we see a clear uptake in participation, more oligomeric targets released, and consistent, albeit modest, improvement of the predictions quality. Looking at the tertiary structure predictions, we observe that ignoring the oligomeric state of the targets hinders modeling success. We also note that some contact prediction groups successfully predicted homomeric interfacial contacts, though it appears that these predictions were not used for assembly modeling. Homology modeling with sizeable human intervention appears to form the basis of the assembly prediction techniques in this round of CASP. Future developments should see more integrated approaches where subunits are modeled in the context of the assemblies they form.
Review of univariate and bivariate exponentiated exponential‐geometric distributions
Authors: Famoye Felix , Lee Carl 
Published: August 2019

AbstractThe exponentiated exponential (or generalized exponential) distribution is a two‐parameter right skewed unimodal density function. A discrete analogue of the distribution is often called the exponentiated exponential‐geometric (or discrete generalized exponential) distribution. We review some methods for generating discrete analogues of the exponentiated exponential distribution and discuss some of their properties. Among the important properties of the univariate distribution are (a) closed form cumulative distribution function and probability mass function and (b) ability to accommodate under‐, equi‐, or over‐dispersion. Some methods to extend the univariate distribution to the bivariate exponentiated exponential‐geometric distribution are discussed. The extension of univariate and bivariate distributions to count data regression models is briefly described. It is expected that this review will serve as a reference and encourage further research work and generalizations of the exponentiated exponential‐geometric distribution.This article is categorized under:
Statistical Models > Linear Models
Data: Types and Structure > Categorical Data
Statistical Models > Generalized Linear Models
The Development of the Turkish Craving for Internet Gaming Scale (CIGS): A Validation Study
Authors: Savci Mustafa , Griffiths Mark D. 
Published: August 2019

AbstractAs the use of digital technology has increased, abuse and addiction to technology have been identified among a minority of users. In the mid-1990s, the concept of internet addiction was first used. Today, almost every digital technology use has been claimed to have a minority of disordered users. One key aspect of addictive substance behaviors is craving. Craving is also an important component of behavioral addictions including digital technology disorders such as Internet Gaming Disorder. The aim of the present study was to develop the Turkish version of the Craving for Internet Gaming Scale (CIGS) via an adaptation of the Penn Alcohol Craving Scale (PACS). The present study comprised 368 adolescents from four different samples. The measures used included the Craving for Internet Gaming Scale, Digital Game Addiction Scale, and Brief Self-Control Scale. The structural validity of CIGS was investigated with Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and criterion validity. The reliability of CIGS was evaluated using Cronbach α internal consistency reliability coefficient and corrected item total correlation coefficients. As a result of EFA, it was found that the five-item CIGS had a single-factor structure. The unidimensional CIGS obtained as a result of EFA was tested with CFA. As a result of CFA, the unidimensional structure of CIGS was confirmed in two different samples. Criterion validity of CIGS was assessed via digital gaming addiction, self-discipline, impulsiveness, daily internet gaming duration, and internet gaming history. As a result of criterion analysis, CIGS was associated with these variables in the expected direction. Finally, according to reliability analysis, the CIGS was found to be a reliable scale. When validity and reliability analysis of the CIGS are considered as a whole, it is concluded that the CIGS is a valid and reliable scale that assesses craving for internet gaming.
Unsteady aerodynamics computation and investigation of magnus effect on computed trajectory of spinning projectile from subsonic to supersonic speeds
Authors: Chughtai F.A. , Masud J. , Akhtar S. 
Published: August 2019

AbstractThis paper describes the extensive numerical investigation carried out on a 203-mm spin-stabilised projectile to study the effects of Magnus force at high angles of attack on the stability and flight-trajectory parameters, for further validation and incorporation in a 6-DOF trajectory solver for flight-stability analysis. Magnus force typically influences the course of flight by causing the projectile to drift from its intended path in addition to generation of inbuilt dynamic instabilities in pitch and yaw orientation and is a function of AoA and spin rate. This study is a consolidation of the authors’ previous research on the same caliber projectile but with time-accurate analysis. It has been found that typically, the Magnus force and moment calculation requires time-accurate Navier Stokes equations to be solved numerically for accurate prediction(1,2). Hence, to complete the extraction of static and dynamic coefficients derivatives, unstructured time-accurate CFD analysis on multiple configurations, ranging from subsonic to supersonic Mach regimes, has been evaluated using Large Eddy Simulation (LES) and found to be suitable for capturing the desired effects. However, the LES simulation requires non-dimensional wall distance (y+) of the order of 0.5 – 1, with LES_IQ > 75% thus, is computationally-intensive. In addition, to cover the entire flight envelope from Charge 1 (249 m/s) to Charge 7 (595 m/s), at spin rate from 500 rad/s to 750 rad/s, 30 cases have been evaluated to generate the time-accurate coefficient library for integration with 6-DOF solver analysis. The results obtained have been compared with the available experimental data and found to be in reasonable agreement. The results of 6-DOF solver, incorporating the extracted coefficients, were compared with firing-table results, which further validated the computational methodology. This study provides an insight on how opposite flow interacts with the attached boundary layer due to spin rate and generates a turbulent interacting flow with variation in vortical structures for Q-Criterion vortex-flow visualization.
Wind turbine wake vortex influence on safety of small rotorcraft
Authors: van der Wall Berend G. 
Published: August 2019

ABSTRACTThe wake vortex of lifting surfaces such as wind turbine blades or fixed-wing aircraft can heavily affect the blade aerodynamics of rotorcraft. Using blade element theory, the pilot control inputs required to mitigate such vortex effects are estimated and compared to the available control margin at the operating condition of interest. In contrast, when no pilot action is performed, the rotor blade flapping caused by the vortex is evaluated and compared to available margins. It is a safety concern when the remaining margins become zero. The influence of the vortex strength, its core radius and orientation to the rotor disk are evaluated and the effect of rotor blade characteristics (Lock number, natural frequency) is investigated.
COMBINED DEPLOYABLE KEYSTROKE LOGGING AND EYETRACKING FOR INVESTIGATING L2 WRITING FLUENCY
Authors: Chukharev-Hudilainen Evgeny , Saricaoglu Aysel , Torrance Mark , Feng Hui-Hsien 
Published: August 2019

AbstractAlthough fluency is an important subconstruct of language proficiency, it has not received as much attention in L2 writing research as complexity and accuracy have, in part due to the lack of methodological approaches for the analysis of large datasets of writing-process data. This article presents a method of time-aligned keystroke logging and eye-tracking and reports an empirical study investigating L2 writing fluency through this method. Twenty-four undergraduate students at a private university in Turkey performed two writing tasks delivered through a web text editor with embedded keystroke logging and eye-tracking capabilities. Linear mixed-effects models were fit to predict indices of pausing and reading behaviors based on language status (L1 vs. L2) and linguistic context factors. Findings revealed differences between pausing and eye-fixation behavior in L1 and L2 writing processes. The article concludes by discussing the affordances of the proposed method from the theoretical and practical standpoints.
EXPLORING SECOND LANGUAGE WRITERS’ PAUSING AND REVISION BEHAVIORS
Authors: Révész Andrea , Michel Marije , Lee Minjin 
Published: August 2019

AbstractThis study investigated the cognitive processes underlying pauses at different textual locations (e.g., within/between words) and various levels of revision (e.g., below word/clause). We used stimulated recall, keystroke logging, and eye-tracking methodology in combination to examine pausing and revision behaviors. Thirty advanced Chinese L2 users of English performed a version of the IELTS Academic Writing Task 2. During the writing task, participants’ key strokes were logged, and their eye movements were recorded. Immediately after the writing task, 12 participants also took part in a stimulated recall interview. The results revealed that, when participants paused at larger textual units, they were more likely to look back in the text and engage in higher-order writing processes. In contrast, during pauses at lower textual units, they tended to view areas closer to the inscription point and engage in lower-order writing processes. Prior to making a revision, participants most frequently had viewed the text that they subsequently revised or their eye gazes had been off-screen. Revisions focused more on language- than content-related issues, but there was a smaller difference in the number of language- and content-focused stimulated recall comments when larger textual units were revised.
MAPPING MASTER’S STUDENTS’ USE OF EXTERNAL SOURCES IN SOURCE-BASED WRITING IN L1 AND L2
Authors: Leijten Mariëlle , Van Waes Luuk , Schrijver Iris , Bernolet Sarah , Vangehuchten Lieve 
Published: August 2019

AbstractThis article examines how master’s students consult and process sources in source-based writing tasks in L1 and L2. Two hundred eighty master’s students wrote a text in their L1 (Dutch) and L2 (English) at the beginning and end of the academic year. They wrote these texts based on three sources: a report, a web text, and a newspaper article. Their writing processes were registered using the Inputlog keylogging program. This allowed us to determine how much time the students spent reading the sources, when they did so, which sources they consulted most frequently, and how often they switched between the various (types of) sources. The quality of the texts was assessed holistically using pairwise comparisons (D-pac). Confirmative factor analysis showed three components to be relevant to describe source use in L1 and L2 writing: (a) initial reading time, (b) interaction with sources, and (c) the degree of variance in source use throughout the writing process. Individual text quality remained stable in L1 and L2 throughout the academic year. Structural equation modeling showed that the approach in source use, especially source interaction, is correlated with text quality, but in L1 only.
Coping with stressful life events: Cognitive emotion regulation profiles and depressive symptoms in adolescents
Authors: van den Heuvel Marieke W. H. , Stikkelbroek Yvonne A. J. , Bodden Denise H. M. , van Baar Anneloes L. 
Published: August 2019

AbstractCognitive strategies that adolescents use to cope with negative emotions might show distinct profiles of cognitive emotion regulation strategies, which could be differentially associated with depressive symptoms. In total, 411 Dutch adolescents who had experienced at least one stressful life event that required some coping strategy participated in this study, including 334 nonclinical and 77 clinically depressed adolescents (12–21 years). A person-centered approach with Latent Profile Analysis was used to identify underlying profiles of cognitive emotion regulation based on the adolescents’ reports of their use of cognitive emotion regulation strategies when they were confronted with stressful life events. Nine different strategies, five adaptive and four maladaptive, were used as indicators. Four profiles with distinct features were found in the nonclinical sample, as well as in the combined sample of nonclinical and clinically depressed adolescents:Low Regulators,High Regulators,Maladaptive Regulators, andAdaptive Regulators. In both samples, the High Regulators profile was most commonly used, followed by the Adaptive, Maladaptive, and Low Regulators profile. Maladaptive Regulators endorsed higher levels of depressive symptoms relative to Low, High, and Adaptive Regulators. The findings underscore the utility of using a person-centered approach in order to identify patterns of cognitive emotion regulation deficits in psychopathology.
Magnetospheric MultiscaleMission Observations of Reconnecting Electric Fields in the Magnetotail on Kinetic Scales
Authors: Macek W. M. , Silveira M. V. D. , Sibeck D. G. , Giles B. L. , Burch J. L. 
Published: August 2019

AbstractWe examine the role of ions and electrons in reconnection using the highest resolution observations from theMagnetospheric Multiscalemission on kinetic ion and electron scales. We report magnetic field and plasma observations from several approaches to the electron diffusion region in the current sheet in 2018. Besides magnetic field reversals, changes in the direction of flow velocity, ion and electron heating,Magnetospheric Multiscaleobserved large fluctuations in the electron flow speeds in the magnetotail. We have verified that when the field lines and plasma become decoupled, a large reconnecting electric field related to the Hall current (1–10 mV/m) is responsible for fast reconnection in the ion diffusion region. Although inertial acceleration forces remain moderate (1–2 mV/m), the electric fields resulting from the electron pressure tensor provide the main contribution to the generalized Ohm's law at the neutral sheet (as large as 200 mV/m). This illustrates that when ions decouple electron physics dominates.
Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway
Authors: Duan Peng-yu , Ma Yuan , Li Xi-na , Qu Feng-zhi , Ji Liang , Guo Xiao-yu , Zhang Wang-jun , Xiao Fan , Li Le , Hu Ji-sheng , Sun Bei , Wang Gang 
Published: August 2019

AbstractCurrently, preliminary results have confirmed the existence of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL)-dependent necroptosis of pancreatic acinar cells during early acute pancreatitis (AP), which might be a potential target for the effective regulation of necroinflammatory injury. However, the exact effect of receptor-interacting protein kinase 1 (RIPK1)-dependent regulated acinar cell necrosis on AP is still uncertain. In our study, we first explored the changes in the degree of local and systemic inflammation in AP rats when the activation of acinar cell RIPK1 was inhibited. The RIPK1 inhibitor Nec-1 was used to treat rats, and the levels of related inflammatory markers, necrosis indicators and apoptotic indicators were measured. Changes in pancreatic nuclear factor κB (NF-κB) and aquaporin 8 (AQP8) expression were noted. Next, the expression of AQP8 in AR42J cells was inhibited, and the degree of cell necrosis and inflammatory damage was found to be significantly reduced. Most importantly, we demonstrated that the RIPK1/NF-ĸB/AQP8 axis might be a potential regulatory pathway mediating RIPK1-dependent regulated acinar cell necrosis in early AP. Finally, we used the NF-κB inhibitor PDTC and Nec-1 to treat rats in different groups and measured the degree of pathological pancreatic injury, the activation of RIPK1, and the expression of NF-κB and AQP8. In summary, we hypothesized that there might be a RIPK1/NF-ĸB/AQP8 pathway controlling RIPK1-dependent regulated necrosis of acinar cells in AP, which might be a promising therapeutic target against AP-related injury.
Large-area borophene sheets on sacrificial Cu(111) films promoted by recrystallization from subsurface boron
Authors: Wu Rongting , Gozar Adrian , Božović Ivan 
Published: August 2019

AbstractBorophene, an atomically thin covalently bonded boron sheet, has attracted great attention as a novel quantum material because of its structural tunability and potential utilization in flexible and transparent electronics. So far, borophene has been synthesized on silver or copper single crystals, but these substrates are small, very expensive, and unsuitable for study of transport properties or electronics applications. Here, we report synthesis of borophene on nanometer-scale thick Cu(111) films grown on sapphire. We have developed a process of enlarging faceted borophene islands, by repeated submersion of boron into copper at high temperature and resurfacing and re-crystallization at lower temperature. This discovery was enabled by real-time feedback from low-energy electron microscopy and diffraction. We demonstrate synthesis of borophene as faceted micrometer-size monocrystal islands or as full-monolayer sheets. The process is scalable to wafer size; moreover, Cu films could be sacrificed and sapphire reused. Our work opens the door for new experiments and brings applications one step closer.
Aluminum stress differentially affects physiological performance and metabolic compounds in cultivars of highbush blueberry
Authors: Cárcamo María Paz , Reyes-Díaz Marjorie , Rengel Zed , Alberdi Miren , Omena-Garcia Rebeca Patrícia , Nunes-Nesi Adriano , Inostroza-Blancheteau Claudio 
Published: August 2019

AbstractAluminum (Al) toxicity is one of the major factors that limit the growth and production of crops in acid soils. Highbush blueberry (Vaccinium corymbosumL.) cultivars differing in resistance to Al toxicity regarding root growth and photosynthetic performance were used. In this study, we compared the physiological and metabolic strategies to cope with Al toxicity among the highbush blueberry cultivars [two new ones (Camellia and Cargo) and three established ones (Brigitta (Al-resistant), Star and Duke)]. Aluminum concentration in roots and leaves increased in all cultivars after 24 and 48 h of exposure to Al, but less so in roots of cultivar Camellia and leaves of cultivar Cargo. These two cultivars displayed minor effects of Al exposure in terms of photosynthetic activity in comparison with the established cultivars. Furthermore, Cargo did not vary fluorescence parameters, whereas Camellia exhibited a decrease in effective quantum yield (ΦPSII) and electron transport rate (ETR) and a change in non-photochemical quenching (NPQ) and maximum quantum yield (Fv/Fm) under Al after 48 h. The Al treatment increased total phenols in leaves of Brigitta, Cargo, and Camellia, whereas antioxidant activity increased in Star and Cargo after 48 h. Aluminum exposure decreased malate concentration in roots of all cultivars, but no change was noted in fumarate concentration. The antioxidant activity correlated with photosynthetic performance and the total phenol concentration in the leaves of new cultivars exposed to Al, suggesting enhanced resistance in the short-term experiment. The principal component analysis separated the new from the established cultivars. In conclusion, the new cultivars appear to be more Al-resistant than the established ones, with Star being most Al-sensitive. Regarding the Al-resistance mechanisms of the new cultivars, it is suggested that Camellia could have a root Al-exclusion mechanism under Al toxicity. This mechanism could be explained by low Al concentration in roots, suggesting that this cultivar could exude organic acid, allowing to chelate Al in the rhizosphere. Nonetheless, further researches are needed to confirm this assumption.