bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quercetin Loaded Nanoparticles in Targeting Cancer: Recent Development
Authors: Vinayak Manjula , Maurya Akhilendra K. 
Published: July 2019

:The spread of metastatic cancer cell is the main cause of death worldwide. Cellular and molecular basis of the action of phytochemicals in the modulation of metastatic cancer highlights the importance of fruits and vegetables. Quercetin is a natural bioflavonoid present in fruits, vegetables, seeds, berries, and tea. The cancer-preventive activity of quercetin is well documented due to its anti-inflammatory, anti-proliferative and anti-angiogenic activities. However, poor water solubility and delivery, chemical instability, short half-life, and low-bioavailability of quercetin limit its clinical application in cancer chemoprevention. A better understanding of the molecular mechanism of controlled and regulated drug delivery is essential for the development of novel and effective therapies. To overcome the limitations of accessibility by quercetin, it can be delivered as nanoconjugated quercetin. Nanoconjugated quercetin has attracted much attention due to its controlled drug release, long retention in tumor, enhanced anticancer potential, and promising clinical application. The pharmacological effect of quercetin conjugated nanoparticles typically depends on drug carriers used such as liposomes, silver nanoparticles, silica nanoparticles, PLGA (Poly lactic-co-glycolic acid), PLA (poly(D,L-lactic acid)) nanoparticles, polymeric micelles, chitosan nanoparticles, etc.:In this review, we described various delivery systems of nanoconjugated quercetin like liposomes, silver nanoparticles, PLGA (Poly lactic-co-glycolic acid), and polymeric micelles including DOX conjugated micelles, metal conjugated micelles, nucleic acid conjugated micelles, and antibody-conjugated micelles on in vitro and in vivo tumor models; as well as validated their potential as promising onco-therapeutic agents in light of recent updates.
Molecular Characterization using Directed Amplification ‎of Minisatellite-region DNA (DAMD) Marker in Ficus Sycomorus L. (Moraceae)
Authors: Saleh Basel 
Published: July 2019

Background:
Ficus sycomorus L. species exhibited great importance with various applications in pharmacology and medicine studies. However, little attention has been given to its molecular characterization.

Objective:
The study aimed to assess DNA genetic diversity among 16 genotypes of F. sycomorus L. species.

Methods:
Directed Amplification of Minisatellite-region DNA (DAMD) marker has been employed to investigate the genetic relationship among the studied genotypes of F. sycomorus L. species based on the estimated Percent Disagreement Values (PDV).

Results:
Twenty-four DAMD primers produced 194 bands, of which, 145 (74.742%) were polymorphic with Polymorphic Information Content (PIC) average of 0.219. DAMD-PCR application highlighted 12 unique markers characteristic for some studied genotypes. Cluster analysis showed that the studied F. sycomorus L. genotypes were split into two main distinguished clusters, each one was considered as a subspecies. In this respect, F. sycomorus14 and F. sycomorus15 genotypes were considered as subspecies too far from the second one containing the remaining genotypes.

Conclusion:
The DAMD assay successfully highlighted genetic diversity within F. sycomorus species. More accurate molecular markers are required to confirm the current data.
The Effects of Cultural Background and Past Usage on Iranian- Australians’ Appreciation of Urban Parks and Aesthetic Preferences
Authors: Yazdani Nasim 
Published: July 2019

To understand how newcomers and established immigrants perceive cultural landscapes that have been imbued with a nationality’s cultural meanings and heritage, exploring the cultural background and landscape myths and values of that immigrants’ community can be a starting point. Examining whether immigrants perceive or prefer those values in a new landscape setting requires a wider understanding of immigrants’ activities, preferences, and expectations.The present paper aims to investigate how Australian urban park landscape settings may be perceived by Iranian immigrants in terms of having aesthetic attributes, and how they use these spaces. It approaches the issue of immigration and park experiences through seeking the links between park settings and the way immigrants see and interpret them based on their cultural, social, and geographical backgrounds. It particularly focuses on Iranian immigrants and Iran’s cultural landscape to explore different views of constructed natural landscapes and their effects on park usage and aesthetic preferences. This study explores how the icons of Iranian cultural landscape (Persian garden), urban park design, and past park use patterns of these immigrants may mediate interactions with new park environments, and how they may contribute to evoke a ‘sense of aesthetic’. It applies survey questionnaire, semi-structured indepth individual interview, and Q methodology with photographs as research methods, and employs theories of ‘place’ and ‘landscape visual characters’ to explore park usage and aesthetic preferences in both contexts: Iran and Australia.Findings of this study highlight the preference of undertaking ‘passive activities’ in urban park landscapes by Iranian research participants and demonstrate that they highly admire the aesthetic and picturesque aspects of Australian park landscapes. However, they miss the characteristics of Iran’s parks as well as the recreational, social, and sporting activities they used to carry out there.
Postprandial Blood Glucose can be less than Fasting Blood Glucose and this is not a Laboratory Error
Authors: Pant Vivek , Gautam Keyoor , Pradhan Santosh 
Published: July 2019

Higher fasting blood glucose level than post prandial level can be seen in variety of conditions in both normal population and diabetics. Various modifiable factors along with underlying condition of patient behind such laboratory picture are discussed in this article.
Keywords: clinical laboratory; diabetes; fasting blood glucose; postprandial blood glucose.
Pleomorphic Adenoma of the Submandibular Gland: A Case Report
Authors: Khanal Prakash 
Published: July 2019

Salivary gland tumours are relatively rare and constitute about 3-4 % of head and neck tumours. Most of the tumours arise from parotid glands. Submandibular gland tumours are very rare. Pleomorphic adenoma of the submandibular gland is exceedingly rare tumour. Very few studies have been reported in the literature that is exclusively conducted on pleomorphic adenoma affecting submandibular gland. Patients usually present with a slow growing, painless and mobile mass without any other associated symptoms. Radiologic studies are usually unable to differentiate benign from malignant tumours in most cases. Recurrence is rare with complete en bloc excision of the tumour along with submandibular gland. Prognosis is excellent except for the rare cases of malignant transformation. This paper describes a case of pleomorphic adenoma affecting submandibular gland with brief review of current literature on submandibular gland tumours.
Keywords: pleomorphic adenoma; salivary gland; submandibular gland tumours.
Exsolutions d'amphibole, de grenat et de spinelle dans les pyroxènes de roches ultrabasiques : péridotite et pyroxénolites
Authors: Desnoyers Christian 
Published: July 2019

Des lamelles d'exsolution peu fréquentes ont été observées dans les pyroxènes de trois roches ultrabasiques : amphibole dans l'orthopyroxène d'une hartzburgite à amphibole et spinelle extraite des laves du volcan Ataq (Arabie du Sud), lamelles de grenat groupées suivant cinq directions distinctes dans le clinopyroxène d'une pyroxénolite à grenat provenant du pipe de kimberlite de Roberts Victor (Afrique du Sud), lamelles de spinelle dans les pyroxènes d'une webstérite à grenat prélevée dans la série volcanique de Salt Lake Crater, Oahu (Hawaï) . Les différentes phases minérales associées ont été caractérisées par leurs compositions, leurs paramètres cristallins et leurs orientations cristallographiques relatives. Les analyses chimiques des minéraux formant ces roches ont permis d'estimer les conditions physiques de cristallisation : les paragenèses primaires se seraient formées vers 1 300°-1 400° C ; elles auraient ensuite subi une diminution de température jusqu'à 1 100° C environ, sous une pression de 20 kbars pour la péridotite, accompagnée d'une chute de pression allant de 30 kbars à 15-16 kbars pour la pyroxénolite à grenat et de 20 kbars à moins de 15 kbars pour la webstérite à grenat.
Characteristics of Solar Wind Fluctuations at and below Ion Scales
Authors: Pitňa Alexander , Šafránková Jana , Němeček Zdeněk , Franci Luca , Pi Gilbert , Montagud Camps Victor 
Published: July 2019

Abstract
Kinetic-scale fluctuations in magnetized collisionless plasmas, such as a solar wind, attract attention owing to their vital role in the dynamics of the dissipation of free energy to random particle motion. As the free energy cascades in the inertial range of turbulence, fluctuations at ion characteristic scales become more compressible. Measurements show that these fluctuations possess highly oblique propagation angles with respect to the background magnetic field and follow theoretical predictions for kinetic Alfvén waves (KAWs). We performed a large (465 cases) statistical study of normalized fluctuations of the density, bulk velocity, and magnetic field around ion gyroscale and concentrated on (i) their compressibility, (ii) the ratio of density and magnetic field fluctuations, and (iii) the ratio of density and velocity fluctuations. We find that observed fluctuations follow the two-fluid prediction for KAWs generally, but the spread of measured values around their theoretical predictions is large. The analysis of measurement uncertainties shows that the difference between the observed and predicted levels of fluctuations cannot be fully explained by these uncertainties and that the nature of solar wind fluctuations is more complex.
De l’assistance à l’entraide : la fondation de la Fraternité d’Oloron-Sainte-Marie par le pasteur Albert Cadier (1879-1929)
Authors: Gabel Carole 
Published: July 2019

Albert Cadier est né le 23 février 1879 à Osse-en-Aspe, petit village des Basses-Pyrénées. Après ses études de théologie à la faculté de Montauban et de Genève, il est appelé par son père pour devenir son suffragant à l’Église d’Osse-en-Aspe. À peine nommé suffragant, Albert Cadier entreprend très vite d’évangéliser la vallée d’Aspe. Cependant, cette tentative se solde par un échec et c’est vers les populations espagnoles établies à Oloron-Sainte-Marie qu’il se tourne.Influencé par le mouvement du « Réveil » et notamment par la théologie d’Alexandre Vinet, auquel il consacre sa thèse intitulée Vinet et le principe du socialisme, Albert Cadier s’inspire également de l’initiative prise quelques années plus tôt par Toribio de la Cruz, fondateur à Oloron-Sainte-Marie de la « Española », première société de secours mutuels pour les étrangers reconnue en France. Pourtant, en 1901, la situation financière du comité qui le soutenait se dégrade, ce qui l’oblige à rentrer en Espagne.Au printemps 1905, Albert Cadier est invité par sa belle-sœur, épouse de l’avocat Henri Cadier installé à Oloron depuis 1903, pour présider l’École du Dimanche qui se tient chez le couple. À cette occasion, le jeune pasteur rencontre plusieurs familles qu’il visite régulièrement. Il est alors confronté à leur misère et pour pallier leurs difficultés, il fonde la Fraternité d’Oloron-Sainte-Marie. Si dans un premier temps, l’assistance est le moyen le plus efficace pour soulager la misère, le but de cette structure est de responsabiliser l’individu afin que peu à peu, l’entraide entre les membres devienne le point d’ancrage de cette œuvre.
On the identity of Navicula gottlandica (Bacillariophyta), with the description of two new species Navicula eileencoxiana and Navicula bergstromiana from the Australo-Pacific region
Authors: Sabbe Koen , Vyverman Wim , Ector Luc , Wetzel Carlos E. , John Jacob , Hodgson Dominic A. , Verleyen Elie , Van de Vijver Bart 
Published: July 2019

Background and aims – During the past two decades, the subantarctic diatom flora has been the subject of several detailed taxonomic revisions, resulting in the description of a large number of new species. During a survey of the freshwater diatom flora of Macquarie Island (southern Pacific Ocean), an unknown Navicula species was observed showing resemblance to Navicula gottlandica. Populations of similar diatoms (previously reported as N. gottlandica) from Tasmania were also investigated. We here present a detailed morphological analysis of these diatoms, and compare it with the type material of N. gottlandica.
Methods –Materials were analysed using Light and Scanning Electron Microscopy.
Key results –The southern hemisphere populations represent two hitherto unknown taxa here described as Navicula bergstromiana and N. eileencoxiana. Important morphological differences include valve shape, stria density, shape of the central area, ultrastructure of the external central raphe endings, presence of a distinct internal accessory rib, and the relative width of the external longitudinal silica strips covering the valve face with respect to the longitudinal fissures separating these strips. While the new taxa show some affinity with the genus Haslea, the internal apical structure of the raphe, the external structure of the terminal raphe fissures and the central raphe endings (often with tooth-like protrusions, creating the impression of a satellite pore), and the apparent lack of the typical sandwich-type Haslea valve ultrastructure support the position of N. gottlandica and both new taxa within the genus Navicula.
Conclusions – The description of two additional species with close similarities to N. gottlandica (i.e. possessing the typical longitudinal striae/silica strips and tooth-like protrusions in hooked central raphe endings) suggests that the N. gottlandica species group is more diverse than previously thought. The existence of closely similar Navicula species recently described from rivers in tropical South America but also from marine littoral samples in South and North America and China, raises intriguing questions about their phylogenetic relationships, ecology and biogeography.
La perception du carcajou/glouton par les Inuit du Nord canadien : Du passé au présent
Authors: Laugrand Frédéric 
Published: July 2019

Le carcajou ou glouton est un animal que les Inuit du Nord canadien perçoivent comme un être vorace et puissant. Souvent associé au loup, il occupe une place singulière dans le bestiaire de ces peuples. Prédateur, nomade, il est aussi charognard mais surtout voleur, capable de mettre en péril les humains qu’il suit et dont il détruit les caches à viande. Fourbe à l’image des « tricksters », sa ruse et sa détermination en font un adversaire redoutable pour les animaux comme pour les humains. Toutes ces caractéristiques lui donnent mauvaise réputation dans la vie quotidienne mais le prédestinent à devenir un puissanttuurngaq, un esprit auxiliaire, dans le domaine chamanique. Le carcajou est ainsi un être ambivalent qui suscite la crainte et la hantise des chasseurs.
Des loups dans l’Arctique yukonnais : Rencontre avec des personnes singulières
Authors: Cappe Aiko 
Published: July 2019

À Old Crow, une petite communauté de Vuntut Gwich’in située aux confins du Yukon, s’étend un vaste territoire à la population variée. Parmi eux, se trouve un impitoyable stratège : le loup. Il est aussi difficile de suivre ses traces que celles qu’il laisse chez les humains qui le côtoient. Le loup se révèle alors de multiples manières, à condition que le chercheur s’éloigne de ses idées préconçues et qu’il adopte une certaine flexibilité. Cette flexibilité est d’autant plus nécessaire que les loups ne se montrent pas. Il s’agit alors de faire l’ethnographie d’individus à l’altérité radicale et qui demeurent invisibles. Ce terrain de recherche se situe donc à la croisée des chemins, de l’humain à l’animal, du tangible à l’intangible. Ces loups n’usent pas de mots et pourtant, cette expérience ethnographique nous plonge dans un univers sensible, riche de sens et d’informations.
A Ligand Field Molecular Mechanics Study of CO2‐Induced Breathing in the Metal–Organic Framework DUT‐8(Ni)
Authors: Melix Patrick , Paesani Francesco , Heine Thomas 
Published: July 2019

AbstractFlexible metal–organic Frameworks (MOFs) are an interesting class of materials due to their diverse properties. One representative of this class is the layered‐pillar MOF DUT‐8(Ni). This MOF consists of Ni2 paddle wheels interconnected by naphthalene dicarboxylate linkers and dabco pillars (Ni2(ndc)2(dabco), ndc = 2,6‐naphthalene–dicarboxylate, dabco = 1,4‐diazabicyclo‐[2.2.2]‐octane). DUT‐8(Ni) undergoes a volume change of over 140% upon adsorption of guest molecules. Herein, a ligand field molecular mechanics (LFMM) study of the CO2‐induced flexibility of DUT‐8(Ni) is presented. LFMM is able to reproduce experimental and DFT structural features as well as properties that require large simulation cells. It is shown that the transformation energy from a closed to open state of the MOF is overcompensated fivefold by the host–guest interactions. Structural characteristics of the MOF explain the shape of the energy profile at different loading states and provide useful insights to the interpretation of previous experimental results.
Community, household, and individual correlates of sleep behaviors in Guyanese female youth
Authors: Singh Evanna I. , Vitzthum Virginia J. 
Published: July 2019

AbstractObjectivesChronic sleep loss among youth is a worldwide health problem. Since research on its predictors is often limited to high‐income countries, it is unclear if these findings are generalizable to all populations. To address this gap from an ecological perspective, we evaluated the associations between adolescents' sleep behaviors and several factors at the community, household, and individual levels in a middle‐income country.MethodsThis was a cross‐sectional study of 73 girls (mean age = 14.5 y; range = 11–18 y) in rural and urban communities in Guyana. Sleep behaviors (nap‐duration, bedtime, rise‐time, night‐bed‐duration, and sleep‐duration) were assessed with interviews and monitored up to 7 consecutive days using waist‐worn accelerometers.ResultsSimilar to other settings, Guyanese urban youth reported significantly later bedtimes than rural youth, and increasing age was associated with later bedtime and shorter night‐bed‐duration. In contrast to the association observed in high‐income countries, increasing household poverty scores in Guyana were associated with longer night‐bed‐duration.ConclusionsAlthough the relationships between locale, age, and sleep in Guyana paralleled patterns seen in high‐income countries, the positive relationship between poverty and sleep diverges from previous reports. These findings suggest that predictors of chronic sleep loss seen in high‐income countries are likely to differ from those in middle‐ and low‐income countries. More sleep studies in underrepresented populations are needed to gain a comprehensive understanding of adolescent sleep behavior and its correlates.
Study of carrier frequency of Warsaw breakage syndrome in the Ashkenazi Jewish population and presentation of two cases
Authors: Rabin Rachel , Hirsch Yoel , Johansson Martin M. , Ekstein Joseph , Zeevi David A. , Keena Beth , Zackai Elaine H. , Pappas John 
Published: July 2019

AbstractWarsaw breakage syndrome (WABS), caused by bi‐allelic variants in the DDX11 gene, is a rare cohesinopathy characterized by pre‐ and postnatal growth retardation, microcephaly, intellectual disability, facial dysmorphia, and sensorineural hearing loss due to cochlear hypoplasia. The DDX11 gene codes for an iron–sulfur DNA helicase in the Superfamily 2 helicases and plays an important role in genomic stability and maintenance. Fourteen individuals with WABS have been previously reported in the medical literature. Affected individuals have been of various ethnic backgrounds with different pathogenic variants. We report two unrelated individuals of Ashkenazi Jewish descent affected with WABS, who are homozygous for the c.1763‐1G>C variant in the DDX11 gene. Their phenotype is consistent with previously reported individuals. RNA studies showed that this variant causes an alternative splice acceptor site leading to a frameshift in the open reading frame. Carrier screening of the c.1763‐1G>C variant in the Jewish population revealed a high carrier frequency of 1 in 68 in the Ashkenazi Jewish population. Due to the high carrier frequency and the low number of affected individuals, we hypothesize a high rate of miscarriage of homozygous fetuses and/or subfertility for carrier couples. If the carrier frequency is reproducible in additional Ashkenazi Jewish populations, we suggest including DDX11 to Ashkenazi Jewish carrier screening panels.
From land and sea, long‐term data reveal persistent humpback whale (Megaptera novaeangliae) breeding habitat in New Caledonia
Authors: Derville Solène , Torres Leigh G. , Dodémont Rémi , Perard Véronique , Garrigue Claire 
Published: July 2019

AbstractLong‐term monitoring is a prerequisite to understanding and protecting long‐lived species such as cetaceans. In New Caledonia, South Pacific, an endangered sub‐population of humpback whales (Megaptera novaeangliae) seasonally congregates for mating and nursing during the austral winter. For more than two decades, dedicated surveys have been conducted at sea and from land to monitor humpback whale presence in a coastal breeding site, the South Lagoon.Methods were developed to investigate space use patterns and their temporal variations over the long term using a joint dataset of boat‐based and land‐based observations (1995–2017). A total of 2651 humpback whale groups were observed, including 1167 from land and 1484 at sea (of which 30% were initially detected by the land‐based observers).Humpback whales displayed a persistent space use pattern over this 23 year period, consistent social composition over the years, and an increase in the group encounter rates from land and at sea. The core area of use by humpback whales was characterized in the austral winter by stable and relatively low sea surface temperature (22°C). Whales consistently occupied nearshore waters from 10 to 200 m deep and open to the ocean. Waters surrounded by dense coral reefs were avoided.Although humpback whale distribution patterns were persistent and occurrence was found to increase over two decades, a mismatch between humpback whale critical habitat and marine protected areas was revealed. In the context of growing anthropogenic pressure from tourism and industrial development, these findings should be incorporated into local management efforts to protect the endangered Oceania humpback whale in one of its main breeding sites.