bluuebunny/crossref_metadata_2025_split huggingface dataset:
The purification and identification of human blood serum proteins with affinity to the antitumor active RL2 lactaptin using magnetic microparticles
Authors: Manko Nazar , Starykovych Marina , Bobak Yaroslav , Stoika Rostyslav , Richter Vladimir , Koval Olga , Lavrik Inna , Horák Daniel , Souchelnytskyi Serhiy , Kit Yuriy 
Published: July 2019

AbstractThe cytopoxic effect of RL2 lactaptin (the recombinant analog of proteolytic fragment of human kappa‐casein) toward tumor cells in vitro and in vivo presents it as a novel promising antitumor drug. The binding of any drug with serum proteins can affect their activity, distribution, rate of excretion and toxicity in the human body. Here, we studied the ability of RL2 to bind to various blood serum proteins. Using magnetic microparticles bearing by RL2 as an affinity matrix, in combination with mass spectrometry and western blot analysis, we found a number of blood serum proteins possessing affinity for RL2. Among them IgA, IgM and IgG subclasses of immunoglobulins, apolipoprotein A1 and various cortactin isoforms were identified. This data suggests that in the bloodstream RL2 lactaptin takes part in complicate protein–protein interactions, which can affect its activity.
Problems in the neighbourhood: Formulating noise complaints across dispute resolution services
Authors: Alexander Marc , Stokoe Elizabeth 
Published: July 2019

AbstractWhen people are in dispute with their neighbours, there are multiple routes to resolution, and different services have a range of remits to support it. This article explores how noise complaints are reported to dispute resolution mediation and local council environmental services in the United Kingdom. A collection of 315 recorded telephone calls were transcribed and analysed using discursive psychology, underpinned by conversation analytic methods. Analysis focused on how the same kinds of noise complaint were formulated for the remit and provision of the service called. In mediation calls, callers directly attributed the source of the noise to the agent of its production (e.g., “it's about the neighbour”). However, reference to “the neighbour” was typically omitted (at least initially) in calls to environmental health services (e.g., “I need to speak to someone about disturbance”). This comparative analysis of different settings reveals the significance of service remit for the design of complaints and the relevance of attributing cause in making a case for aid. Comparing two settings provides a propitious opportunity to demonstrate that noise is not a physically objective phenomenon or neutral category but institutionally formulated social conduct.
Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum
Authors: Maciel Ana J. , Lacerda Caroline P. , Danielli Letícia J. , Bordignon Sérgio A. L. , Fuentefria Alexandre M. , Apel Miriam A. 
Published: July 2019

AbstractThe purpose of this work was to determine the chemical composition and evaluate the antichemotactic, antioxidant, and antifungal activities of the essential oil obtained from the species Cryptocarya aschersoniana Mez, Cinnamomum amoenum (Ness & Mart.) Kosterm., and Schinus terebinthifolia Raddi, as well as the combination of C. aschersoniana essential oil and terbinafine against isolates of dermatophytes. Allo‐aromadendrene, bicyclogermacrene, and germacrene B were identified as major compounds in essential oils. The essential oil of C. aschersoniana shown 100 % inhibitory effect on leukocyte migration at the concentration of 10 μg/mL while S. terebinthifolia oil presented 80.1 % inhibitory effect at the same concentration. Only S. terebinthifolia oil possessed free‐radical‐scavenging activity which indicates its antioxidant capacity. The essential oils were also tested against fungal isolates of dermatophyte species (Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis and Microsporum gypseum), resulting in MIC ranging from 125 μg/mL to over 500 μg/mL. C. aschersoniana oil combined with terbinafine resulted in an additive interaction effect. In this case, the essential oil may act as a complement to conventional therapy for the topical treatment of superficial fungal infections, mainly because it is associated with an anti‐inflammatory effect.
Pax6 expression highlights regional organization in the adult brain of lungfishes, the closest living relatives of land vertebrates
Authors: López Jesús M. , Morona Ruth , Moreno Nerea , Lozano Daniel , Jiménez Sara , González Agustín 
Published: July 2019

AbstractThe Pax6 gene encodes a regulatory transcription factor that is key in brain development. The molecular structure of Pax6, the roles it plays and its patterns of expression in the brain have been highly conserved during vertebrate evolution. As neurodevelopment proceeds, the Pax6 expression changes from the mitotic germinal zone in the ventricular zone to become distributed in cell groups in the adult brain. Studies in various vertebrates, from fish to mammals, found that the Pax6 expression is maintained in adults in most regions that express it during development. Specifically, in amphibians, Pax6 is widely expressed in the adult brain and its distribution pattern serves to highlight regional organization of the brain. In the present study, we analyzed the detailed distribution of Pax6 cells in the adult central nervous system of lungfishes, the closest living relatives of all tetrapods. Immunohistochemistry performed using double labeling techniques with several neuronal markers of known distribution patterns served to evaluate the actual location of Pax6 cells. Our results show that the Pax6 expression is maintained in the adult brain of lungfishes, in distinct regions of the telencephalon (pallium and subpallium), diencephalon, mesencephalon, hindbrain, spinal cord, and retina. The pattern of Pax6 expression is largely shared with amphibians and helps to understand the primitive condition that would have characterized the common ancestors to all sarcopterygians (lobe‐finned fishes and tetrapods), in which Pax6 would be needed to maintain specific entities of subpopulations of neurons.
Corporate social responsibility embeddedness through a social network analysis: The case of an Italian multiutility company
Authors: Gusmerotti Natalia Marzia , Testa Francesco , Macellari Margherita , Frey Marco 
Published: July 2019

AbstractTo gain substantial benefits, corporate social responsibility (CSR) needs to be embedded within an organization. Through a social network analysis, this study analyzes to what extent an Italian multiutility company, strategically committed to sustainability, integrates social and environmental issues in its strategy, operations, and routines. The paper aims to answer the following two questions: (a) How can an investigation of the level of information exchange help in identifying whether CSR is embedded or peripheral in a company?; (b) how can an investigation of the role of the CSR department help in identifying whether CSR is embedded or peripheral in a company? The study reveals the frequency and density of information exchange regarding social and environmental issues among 67 business units as well as highlighting the real role played by the CSR department. This research contributes to the current debate on CSR embeddedness by showing how an exploration of internal social networks reveals the extent to which CSR is integrated within strategy, operations, and routines. It also provides useful suggestions for managers on ways to improve the level of integration.
Data replication mechanisms in the peer‐to‐peer networks
Authors: Mohammadi Behnaz , Navimipour Nima Jafari 
Published: July 2019

SummaryPeer‐to‐peer (P2P) network is a distributed network in which nodes with similar capabilities exchange information with each other. Due to the nature of the P2P network distribution, numerous network message transformation is required to exchange the data between nodes over the network, which may increase access latency. Because of the high amount of the stored data in the P2P networks, the replication of data is very important. A large amount of data is handled using data replication to increase data access, reduce access latency, and increase data availability. This issue has an important role in the P2P networks, but there is no complete and systematic research in this field. Therefore, this paper aims to provide a comprehensive study of data replication mechanisms in the P2P networks. The 1027 papers have been identified and have been reduced to 213 main studies using the paper selection process. Moreover, in this paper, the major advances are reviewed in four main groups (structured, unstructured, super‐peer, and hybrid networks), and the new challenges are also highlighted. Moreover, the open issues and guidelines for future studies are presented.
Behavioral response to tactile stimuli relates to brain response to affective touch in 12‐month‐old infants
Authors: Miguel Helga O. , Gonçalves Óscar F. , Sampaio Adriana 
Published: July 2019

AbstractAffective touch activates a brain network responsible for processing social–emotional stimuli in infants, children, and adults, with a core node in the superior temporal sulcus (STS). STS is known to be a region highly susceptible to individual variability, including for tactile stimuli processing. However, little is known about how this region is recruited to process affective touch in infancy. The aim of this study was to examine brain activity to affective touch in the temporal region (STS) and understand if it relates to behavioral patterns of sensory‐over responsivity (SOR) to touch. Twelve‐month‐old infants (n = 24) were given affective and discriminative stimuli to the forearm while they were watching a silent movie. Brain activation was recorded in the STS for measures of oxy‐hemoglobin (HbO2) and deoxy‐hemoglobin (Hbb) using functional near infra‐red spectroscopy (fNIRS). Aversive responses to tactile stimuli were measured using the Infant‐Toddler Sensory Profile. A significant hemodynamic response increase in HbO2 to affective touch was observed in the STS for infants with less aversive behavioral responses to tactile stimuli. The findings suggest that brain activity in the STS for affective touch might be related to individual differences in the affective reaction toward touch.
Altered association between executive functions and reading and math fluency tasks in children with reading difficulties compared with typical readers
Authors: Meiri Raya , Levinson Ophir , Horowitz‐Kraus Tzipi 
Published: July 2019

AbstractFluent reading in children relies on executive functions (EF). Recent research suggests that EF skills also affect arithmetic abilities. Children with reading difficulties (RD) experience deficits in EF. It is still unknown to what extent these EF deficits are the basis for both reading and arithmetic skills in children with RD compared with typical readers. To define the role of EF in reading and arithmetic in children with RD and typical readers, EF measures and reading and arithmetic fluency and non‐fluency measures were assessed in 8 to 12‐year‐old children with RD and age‐matched typical readers. Comparison and correlation analyses were performed within and between the two groups. Children with RD scored lower on reading and arithmetic fluency and non‐fluency tasks compared with typical readers. For both groups, fluency measures were lower than non‐fluency measures. Strong correlations were found within the entire study population between fluency measures and EF, as well as between non‐fluency measures and EF compared with mixed correlations observed for the groups separately. Fluency was related to subcomponents of EF expressed in both reading and arithmetic domains for the two groups. The role of each domain and comparison with non‐fluency results for each group are discussed.
How (co)evolution alters predator responses to increased mortality: extinction thresholds and hydra effects
Authors: Cortez Michael H. , Yamamichi Masato 
Published: July 2019

AbstractPopulation responses to environmental change depend on both the ecological interactions between species and the evolutionary responses of all species. In this study, we explore how evolution in prey, predators, or both species affect the responses of predator populations to a sustained increase in mortality. We use an eco‐evolutionary predator–prey model to explore how evolution alters the predator extinction threshold (defined as the minimum mortality rate that prevents population growth at low predator densities) and predator hydra effects (increased predator abundance in response to increased mortality). Our analysis identifies how evolutionary responses of prey and predators individually affect the predator extinction threshold and hydra effects, and how those effects are altered by interactions between the evolutionary responses. Based on our theoretical results, we predict that it is common in natural systems for evolutionary responses in one or both species to allow predators to persist at higher mortality rates than would be possible in the absence of evolution (i.e., evolution increases the predator mortality extinction threshold). We also predict that evolution‐driven hydra effects occur in a minority of natural systems, but are not rare. We revisited published eco‐evolutionary models and found that evolution causes hydra effects and increases the predator extinction threshold in many studies, but those effects have been overlooked. We discuss the implications of these results for species conservation, predicting population responses to environmental change, and the possibility of evolutionary rescue.
Heart failure from cancer therapy: can we prevent it?
Authors: Totzeck Matthias , Mincu Raluca I. , Heusch Gerd , Rassaf Tienush 
Published: July 2019

AbstractAimsConventional cytotoxic chemotherapy is still among the most effective treatment options for many types of cancer. However, cardiotoxicity, notably the decrease in left ventricular function under these regimens, can impair prognosis. Thus, prevention and treatment of cardiotoxicity are crucial. The present meta‐analysis aims to assess the efficacy of beta‐blockers or angiotensin‐converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARBs) for prevention of cardiotoxicity.Methods and resultsWe systematically searched Pubmed, Cochrane, EMBASE, and Web of Science databases for randomized controlled trials published until February 2019. The analysis included randomized studies that reported on left ventricular ejection fraction (LVEF) after 6 months of chemotherapy in cancer patients who received beta‐blockers or ACE inhibitors/ARBs for prevention of cardiotoxicity compared with controls. Studies on combination cardioprotective therapies were excluded from the analysis. The primary endpoint was prevention of a decrease in LVEF as defined by the individual study and as assessed by either transthoracic echocardiography or magnetic resonance imaging. We here show that patients under anthracycline‐based chemotherapy have a moderate yet significant benefit in LVEF from beta‐blockers or ACEs/ARBs. The beta‐blocker analysis included 769 cancer patients, and the ACE inhibitors/ARBs analysis included a total of 581 cancer patients. The mean LVEF difference between the beta‐blocker group and the control group was 2.57% (95% confidence interval 0.63–4.51, P = 0.009). The mean difference for ACE inhibitors/ARBs was 4.71% (95% confidence interval 0.38–9.03, P = 0.03). However, the beneficial effects throughout the studies were variable as documented by significant heterogeneity between the studies.ConclusionsSystematic evidence is needed to solidly found recommendations for cardioprotective prevention during chemotherapy. Likewise, trials on other neurohumoral drugs (spironolactone) and lipid‐lowering approaches are required to improve protection for cardio‐oncology patients.
Mathematical Modelling of the Influence of Ultra‐micro Electrode Geometry on Approach Curves Registered by Scanning Electrochemical Microscopy
Authors: Astrauskas Rokas , Ivanauskas Feliksas , Morkvenaite‐Vilkonciene Inga , Ramanavicius Arunas 
Published: July 2019

AbstractScanning electrochemical microscopy (SECM) is an emerging electroanalytical sensing technique, used to investigate the electrochemical properties of the sample by ultra‐micro‐electrode(UME) scanning probe. UME signal usually is the current, which depends not only on the properties of the evaluated system but also on UME characteristics such as geometry. Variations of UME geometry can decrease accuracy of the measurement, and then correct analysis of the SECM data becomes almost impossible. In the present work, we studied the precision of measurements with three different the most frequent types of defected UME's ((i) recessed‐UME, (ii) outwarded‐UME, (iii) cone‐UME). Measurement results were compared with that obtained with not defected standard‐plane‐UME. Computational experiment was performed with SECM model using diffusion equations with non‐rectangular border conditions to calculate estimated currents for these three types of defected UMEs and to compare them with that for standard‐plane‐UME. In order to test the correctness of the model, computations for recessed‐UME model were compared with data of real‐recessed‐UME experiment.
Therapist adherence to family‐based treatment for adolescents with anorexia nervosa: A multi‐site exploratory study
Authors: Dimitropoulos Gina , Lock James D. , Agras William Stewart , Brandt Harry , Halmi Katherine A. , Jo Booil , Kaye Walter H. , Pinhas Leora , Wilfley Denise E. , Woodside D. Blake 
Published: July 2019

AbstractObjectiveThis exploratory study is the first to examine family‐based treatment (FBT) adherence and association to treatment outcome in the context of a large‐scale, multi‐centre study for the treatment of adolescents with anorexia nervosa.MethodOne hundred and ninety recorded FBT sessions from 68 adolescents with anorexia nervosa and their families were recruited across multiple sites (N = 6). Each site provided 1–4 tapes per family over four treatment time points, and each was independently rated for therapist adherence.ResultsThere were differences in adherence scores within and between sites. ANOVA produced a main effect for site, F(5, 46) = 8.6, p < .001, and phase, F(3, 42) = 12.7, p < .001, with adherence decreasing in later phases. Adherence was not associated to end of treatment percent ideal body weight after controlling for baseline percent ideal body weight (r = .088, p = .48).ConclusionsResults suggest that FBT can be delivered with adherence in phase one of treatment. Adherence was not associated with treatment outcome as determined using percent ideal body weight.
Shifting brain circuits in pain chronicity
Authors: Youssef Andrew M. , Azqueta‐Gavaldon Monica , Silva Katie E. , Barakat Nadia , Lopez Natalia , Mahmud Farah , Lebel Alyssa , Sethna Navil F. , Zurakowski David , Simons Laura E. , Kraft Eduard , Borsook David 
Published: July 2019

AbstractThe evaluation of brain changes to a specific pain condition in pediatric and adult patients allows for insights into potential mechanisms of pain chronicity and possibly long‐term brain changes. Here we focused on the primary somatosensory system (SS) involved in pain processing, namely the ventroposterolateral thalamus (VPL) and the primary somatosensory cortex (SI). We evaluated, using MRI, three specific processes: (a) somatotopy of changes in the SS for different pain origins (viz., foot vs. arm); (b) differences in acute (ankle sprain versus complex regional pain syndrome‐CRPS); and (c) differences of the effects of CRPS on SS in pediatric versus adult patients. In all cases, age‐ and sex‐matched individuals were used as controls. Our results suggest a shift in concurrent gray matter density (GMD) and resting functional connectivity strengths (rFC) across pediatric and adult CRPS with (a) differential patterns of GMD (VPL) and rFC (SI) on SS in pediatric vs. adult patterns that are consistent with upper and lower limb somatotopical organization; and (b) widespread GMD alterations in pediatric CRPS from sensory, emotional and descending modulatory processes to more confined sensory‐emotional changes in adult CRPS and rFC patterns from sensory‐sensory alterations in pediatric populations to a sensory‐emotional change in adult populations. These results support the idea that pediatric and adult CRPS are differentially represented and may reflect underlying differences in pain chronification across age groups that may contribute to the well‐known differences between child and adult pain vulnerability and resilience.
Comparative analysis of different design of rotary dehumidifier
Authors: Prasad Amarjeet Kumar , Yadav Laxmikant , Yadav Avadhesh 
Published: July 2019

AbstractA one‐dimensional mathematical model has been developed to do the comparative analysis of four design of the desiccant wheel. The mathematical model has been validated with experimental results and shows good agreements with experimental results. In this study, a two‐sector desiccant wheel is modified into a three‐sector wheel by introducing a purge section in the desiccant wheel. Similarly, a four‐sector desiccant wheel is reformed into a six‐sector wheel by installing two purge section in the desiccant wheel and comparative study of these designs have been carried for given ranges of operating conditions. The effect of purge conditions has been also investigated and found that in all operating conditions six‐sector design is a better choice for optimum MRC and ∆T.
GENERAL STAGE–DISCHARGE RELATIONSHIP FOR SHARP‐CRESTED POWER‐LAW WEIRS: ANALYTICAL AND EXPERIMENTAL STUDY
Authors: Vatankhah Ali R. , Khamisabadi M. 
Published: July 2019

AbstractThe efficient use of water for irrigation and agriculture projects depends mainly on measurement of water. Weirs are widely used in irrigation networks to measure flow discharge. Flow estimation through weirs of different shapes is very important in irrigation engineering. Weirs are characterized by a relation between the water head and discharge, which mainly depends on the shape and dimensions of the weir. A power‐law weir is very versatile and allows modelling of weirs with different shapes. The generic results of the power‐law weir can also be applied to its special forms such as triangular, semi‐cubic, parabolic, cubic and rectangular weirs. Up to now, the hydraulic behaviour of a general power‐law weir has not been studied. In this study, sharp‐crested power‐law weirs were studied experimentally and theoretically. For this, weir (Model I) and critical flow (Model II) theories along with Buckingham's theorem of dimensional analysis were used to deduce the stage–discharge relationship of power‐law weirs. A series of laboratory experiments (502 runs) were performed to calibrate the deduced theoretical stage–discharge relationships under free‐flow conditions. The proposed general stage–discharge relationships have an average error less than 1.7%; thus, actual discharge through the channel can be simply and reliably estimated. © 2019 John Wiley & Sons, Ltd.