bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inaticabtagene autoleucel in adult relapsed or refractory B-cell acute lymphoblastic leukemia
Authors: Wang Ying , Lv Lulu , Song Yongping , Wei Xudong , Zhou Hongsheng , Liu Qifa , Xu Kailin , Yan Dongmei , Zhang Cheng , Liu Shuangyou , Jin Jie , Mei Heng , Niu Ting , Liang Aibin , Gu Runxia , Ren Jienan , Feng Yi , Jin Wei , Zhou Yan , Deng Yiping , Wang Jianxiang 
Published: December 2024

Abstract
Before November 2023, CD19 chimeric antigen receptor (CAR) T-cell therapies had not been approved in China for patients with relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL), leaving a significant unmet need. In response, inaticabtagene autoleucel (Inati-cel), a novel CD19 CAR T-cell therapy with a distinct single-chain variable fragment (HI19α), was developed and showed promising efficacy in preliminary clinical research. We conducted a phase 2, single-arm, multicenter study of Inati-cel in adult CD19+ R/R B-ALL in China. The primary end point was the overall remission rate (ORR) at the end of month 3. Forty-eight patients who underwent Inati-cel infusion were evaluated for both efficacy and safety. Among them, 34 patients achieved and maintained remission beyond 3 months, with a 3-month ORR of 70.8% (95% confidence interval [CI], 55.9-83.1). The best ORR was 85.4%, with all responders reaching minimal residual disease negativity. With a median follow-up of 23.7 months, the median duration of remission was 20.7 months (95% CI, 6.4 to not reached), and the median overall survival was not reached (95% CI, 13.0 months to not reached). Additionally, grade ≥3 cytokine release syndrome and neurologic events occurred in 12.5% and 6.2% of patients, respectively. The 2-year follow-up data suggest that Inati-cel demonstrates encouraging and durable responses with manageable safety profiles in R/R B-ALL. Based on the data from this pivotal trial, Inati-cel was approved as the first CAR T-cell therapy for adult R/R B-ALL in China and underscores its potential therapeutic benefits for this patient population. This trial was registered at www.ClinicalTrials.gov as #NCT04684147.
Cause Analysis of Rail Corrugation in Metro Lines Based on System Vibration Characteristics
Authors: Wang Zhiqiang , Lei Zhenyu , Luo Yanyun 
Published: December 2024

AbstractThe mechanism of rail corrugation remains unclear, and the research methods require improvement. The vibration characteristics represent the system’s external manifestations, but a comprehensive analysis is still lacking. Taking the vibration characteristics of the wheel-rail system as a starting point, this study investigates the formation mechanisms of rail corrugation on measured metro lines. The line sections included both steel spring floating slab tracks and long sleeper embedded tracks. First, the wavelength and frequency attributes of rail corrugation were obtained through field measurements. Then, referencing line conditions, three-dimensional finite element numerical models were established, frequency response calculations were performed, and the relationship between the vibration responses of the wheel-rail system and rail corrugation was analyzed. Finally, a parameter sensitivity analysis of the wheel-rail system was conducted to control the further development of rail corrugation. The results show distinct corrugation phenomena on both inner and outer rails in the measured sections. The characteristic wavelengths of inner and outer rail corrugation on the steel spring floating slab track are 34 mm and 59 mm, respectively, and the characteristic wavelengths of inner and outer rail corrugation on the long sleeper embedded track are 46 mm and 47 mm, respectively. The frequency response analysis indicates that the numerical results exhibit eigenfrequencies close to the passing frequencies of the measured corrugations. The formation mechanism of inner rail corrugation on the steel spring floating slab track is attributed to the third-order bending vibration of the wheelset, which leads to the generation of inner rail corrugation. In contrast, the formation mechanism of outer rail corrugation is attributed to the lateral bending vibration of the outer rail. For the long sleeper embedded track, inner rail corrugation is generated by the lateral bending vibration of the inner rail, while outer rail corrugation results from the lateral bending vibration of the outer rail. Appropriate adjustments to the fastener’s vertical and lateral stiffness, as well as the steel spring’s vertical and lateral stiffness, can shift the rail corrugation eigenfrequencies, thereby inhibiting the development of corrugation with the original wavelength. Changes in other parameters have no effect on the rail corrugation eigenfrequencies and only influence the development speed of corrugation with the original wavelength. This research effectively elucidates the cause of rail corrugation from the system vibration perspective and provides a valuable complement to the corrugation analysis method.
Cluster headache and galcanezumab: the first real-world Brazilian study and an expert consensus on its use among other treatments
Authors: Krymchantowski Abouch , Jevoux Carla , Piovesan Élcio Juliato , Valença Marcelo Moraes , Kowacs Fernando , Kowacs Pedro André , Dach Fabíola , Monzillo Paulo Hélio , Bordini Carlos Alberto , Silva-Néto Raimundo Pereira 
Published: December 2024

Abstract
Objective
To present the first Brazilian real-world results with galcanezumab and provide a consensus expert opinion on the prophylactic treatment of cluster headache (CH) in Brazil.

Methods
The first part of the study (real-world results) was observational, prospective, uncontrolled, and descriptive. A sample of 44 consecutive patients with episodic or chronic CH were evaluated and treated in a traditional tertiary clinic from March 2020 to June 2024. The second part (consensus expert opinion) consisted of a survey completed by ten Brazilian headache clinicians with at least 25 years of clinical experience, who published at least 15 headache papers and attended at least 15 national or international headache conferences.

Results
Forty-four patients (86.4% men, 13.6% women) were included. The average age was 45.9 ± 14.2 years. The diagnosis was made 27.3 ± 13.6 years after the onset of headache bouts. In 84.1% of the patients, CH was classified as episodic. Verapamil, lithium, or verapamil plus lithium were prescribed to respectively, 25%, 9.1%, and 6.8% of patients. Galcanezumab was prescribed to all and the majority (65.9%) used a dose of 300 mg once. There was a reduction in headache frequency of ≥ 50% at 3 weeks in 65.9% of patients for all doses of galcanezumab, and in 72.4% of those using galcanezumab 300 mg. Verapamil was recommended as a first-line treatment by 6 of 10 experts and a second-line treatment by the other 4 experts; galcanezumab was recommended as a first-line treatment by 4 of 10 experts and as a second-line treatment by 3 of 10 experts.

Conclusions
This study presented the first real-world data with galcanezumab in Brazilian patients with CH and showed a reduction in headache frequency in most patients. A survey of Brazilian experts not meant to represent the country’s guidelines, favored galcanezumab as either the first or the second option in prophylaxis. Collectively, these results highlighted galcanezumab’s promising efficacy as a new tool in CH patients.
The relationship between self-confidence and attitude of emergency medical technicians towards family presence during resuscitation
Authors: Najafi Jaber , Gilani Neda , Hassankhani Hadi , Ghafourifard Mansour , Dadashzadeh Abbas , Zali Mahnaz 
Published: December 2024

Abstract
Background
Family presence during resuscitation is a controversial issue worldwide. The aim of this study was to investigate the self-confidence and attitudes of Emergency Medical Technicians (EMTs) towards family presence during resuscitation (FPDR).

Methods
In this cross-sectional study, a random sample of 252 EMTs were selected from 110 prehospital emergency centers. Two main questionnaires were used to collect data on the EMTs’ self-confidence and attitudes towards FPDR.

Results
The results showed that the EMTs’ attitudes towards FPDR were lower than the mean (43.69 ± 19.40). In addition, more than 85% of them stated that the resuscitation process was stressful for the patient’s companions. There was a positive correlation between EMTs’ self-confidence and attitudes towards FPDR (r = 0.52, p < 0.01). The results showed that the smaller number of family members present during resuscitation was associated with higher EMTs’ self-confidence and more positive attitudes towards FPDR. Moreover, personnel with more experience, liability insurance, and advanced resuscitation training were significantly more self-confident than other personnel.

Conclusion
A large number of the EMS personnel have a negative attitude towards FPDR, but EMTs, with higher self-confidence, have a more positive attitude. Therefore, it is possible to improve the EMTs attitudes towards FPDR and increase their self-confidence by training them to perform resuscitation in the presence of the family and by preventing people from gathering at resuscitation scenes.
Evolution of transport, accessibility and tourism competitiveness in Extremadura (Spain): a benchmarking analysis
Authors: Sánchez-Rivero Marcelino , Miguel-Barrado Vanessa , Rodríguez-Rangel María Cristina , Pérez-Calderón Esteban 
Published: December 2024

AbstractThe efficiency of the transportation options available to tourists, in terms of convenience and time, directly impacts the competitiveness of a destination in the tourism sector. The aim of this study is to compare how the indicators of accessibility and connectivity of transportation have evolved across Spain's Autonomous Regions. To achieve this, we used indicators related to the sufficiency and connectivity of air and high-speed train services, as well as land accessibility and connectivity, as provided by Exceltur's Monitur reports. For a dynamic analysis, which is essential in assessing this type of infrastructure, we considered the values of these indicators from the first Monitur report (2010) and the most recent one (2018). Based on these values for the 17 Autonomous Regions of Spain, we identified the regions that have gained relative competitiveness and those that have experienced a relative decline. The dynamic analysis conducted in this study has allowed us to classify the regions according to the evolution of their relative competitiveness. It highlights the key areas that destination managers should focus on to design strategies that enhance their competitive position.
Qatar dental student perceptions of Sirona prep-check software for learning crown preparations
Authors: Daas Hanin , Arregui María , Tarrida Lluís Giner , Glanville Rebecca , Ali Kamran 
Published: December 2024

Abstract
Background
Contemporary dental education requires swift assimilation of technological advancements to prepare the future generation of dentists. Integrating digital tools, such as prepCheck software in crown preparations offers a promising avenue for enhancing the learning experiences of dental students. This study aimed to evaluate the perceptions and experiences of undergraduate dental students regarding the use of PrepCheck software for learning crown preparations.

Methods
An interventional study design was employed to investigate the perceptions of undergraduate dental students regarding the use of Sirona prepCheck software their learning experiences in the prosthodontics course at the College of Dental Medicine. were recruited using purposive sampling. Participants received training on crown preparations using standard didactic and practical teaching methods. A total of 64 dental students (Mean age 22.4 years) participated in the study. They were randomly assigned to two groups, 32 participants each. The study group utilized prepCheck software and the control group relied solely on supervisor feedback. Both groups completed their crown preparation labs concurrently, ensuring consistency in training and assessment conditions.

Results
Out of a total number of 66 students enrolled on the course, 64 participated in the study giving a response rate of 96.96%. The overall mean score for all items was 1.01 (95%CI 0.77–1.25), indicating positive perceptions of the participants about prepCheck software. Analysis of variance revealed no significant variation by gender. Thematic analysis of open-ended items identified key themes related to the advantages and challenges of using prepCheck. Advantages included immediate self-evaluation, objective analysis, and feedback, while challenges included operational difficulties and cost concerns.

Conclusion
This study provides insights into the effectiveness of prepCheck in dental education, offering perspectives derived from both quantitative and qualitative analyses. A majority of the participants recommended that digital assessment should be integrated with conventional methods, underscoring the importance of human input through supervisor feedback. The study demonstrates the potential of prepCheck software in enhancing participants’ learning experiences in crown preparation assessment. While digital tools offer advantages such as self-evaluation and objective analysis, they need to be supported with input and feedback from the supervisors.
EdSurvey: an R package to analyze large-scale educational assessments data from NCES
Authors: Zhang Ting , Bailey Paul , Liao Yuqi , Sikali Emmanuel 
Published: December 2024

AbstractThe EdSurvey package helps users download, explore variables in, extract data from, and run analyses on large-scale assessment data. The analysis functions in EdSurvey account for the use of plausible values for test scores, survey sampling weights, and their associated variance estimator. We describe the capabilities of the package in the context of the 2019 National Assessment of Educational Progress (NAEP) High School Transcript Study.
Diversified Communication and Harmony of Chinese culture: a historical investigation into the religious-culture exchanges among the Hans, Tibetans, and Mongolians
Authors: Sun Wuhu , Banbur Dorje , Li Yue 
Published: December 2024

AbstractHow can harmonious communication, integration, and coexistence among different ethnicities with distinct cultures be achieved in a multi-ethnic country? What lessons can we draw from China’s multi-ethnic cultural exchanges throughout history? Are Confucianism, Daoism, and Buddhism exclusive to the culture of the Central Plains? These questions are essential for forging a sense of the Chinese nation as one community and building a shared cultural home of the Chinese nation. Throughout Chinese history, the Han, Tibetan, and Mongolian ethnicities have engaged in mutual exchanges and integrations of their respective religious-cultures, fostering mutual promotion and collective growth, leaving behind valuable experiences that shaped the Chinese cultural pattern of “Diversified Communication and Harmony.” Drawing upon extensive literature and materials documenting the religious-culture exchanges and interactions among the Han, Tibetan, and Mongolian ethnicities since the Tang and Song dynasties, this article investigates the interaction, exchange, and integration history of religious-culture among these ethnicities, aiming to explore the historical evolution of this pattern of “Diversified Communication and Harmony”.
Morphological characteristics, developmental dynamics, and gene temporal expressions across various development stages of Aphis gossypii sexual female
Authors: Lü Jingli , Wang Liuyu , Zhang Kaixin , Li Dongyang , Gao Mengxue , Guo Lixiang , Tang Zhijuan , Gao Xueke , Zhu Xiangzhen , Wang Li , Ji Jichao , Luo Junyu , Cui Jinjie 
Published: December 2024

Abstract
Background
Aphis gossypii (Hemiptera: Aphididae) is a worldwide polyphagous phloem-feeding agricultural pest, and it can produce offspring by sexual or asexual reproduction. Compared with dozens of generations by parthenogenesis, sexual reproduction is performed in only one generation within one year, and little is known about the sexual reproduction of A. gossypii. In this study, sexual females of A. gossypii were successfully obtained through a previously established induction platform, and the morphological characteristics, developmental dynamics, and temporal gene expression were examined. Subsequently, signaling pathways potentially involved in regulating the growth, development, and reproduction of sexual females were investigated.

Results
The morphological observation showed that from the 1st instar nymph to adult, sexual females exhibited a gradually deepened body color, an enlarged body size, longer antennae with a blackened end, and obviously protruding cauda (in adulthood). The anatomy found that the ovaries of sexual females developed rapidly from the 2nd instar nymph, and the embedded oocytes matured in adulthood. In addition, time-course transcriptome analysis revealed that gene expression profiles across the development of sexual females fell into 9 clusters with distinct patterns, in which gene expression levels in clusters 1, 5, and 8 peaked at the 2nd instar nymphal stage with the largest number of up-regulated genes, suggesting that the 2nd instar nymph was an important ovary development period. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that a large number of genes in the sexual female adult were enriched in the TGF-beta signaling pathway and Forkhead box O (FoxO) signaling pathway, highlighting their important role in sexual female adult development and reproduction.

Conclusion
The morphological changes of the sexual female at each developmental stage were revealed for the first time. In addition, time-course transcriptomic analyses suggest genes enriched in the TGF-beta signaling pathway and FoxO signaling pathway probably contribute to regulating the development and oocyte maturation of sexual females. Overall, these findings will facilitate the regulating mechanism research in the growth and development of sexual females by providing candidate genes.
Cystatin D serum level in rheumatoid arthritis and its relation to disease activity
Authors: Mohamed Dalia Mohamed Gamal , Taha Sara Ibrahim , Ibrahim Rehab Ali , Mohammed Mohammed Maher , Arafa Shaymaa Gamal 
Published: December 2024

Abstract
Background
Rheumatoid arthritis (RA) is a chronic autoimmune condition that causes synovitis and functional impairment. Currently, the most often utilized biomarkers for monitoring disease activity and severity are acute phase proteins, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP).
However, discrepancies have been found between the clinical inflammation and their levels. Therefore, there is a strong need for a novel biomarker to forecast how RA will proceed clinically and monitor the response to therapy. This study assessed the diagnostic value of serum cystatin D in RA patients and its potential as a biomarker for disease activity monitoring.

Results
RA patients had considerably greater serum levels of cystatin D than the control group. These values showed a positive correlation with Disease Activity Score-28 (DAS28), ESR, CRP, grayscale synovitis, power Doppler synovitis, grayscale tenosynovitis (p < 0.001), and erosions, sum scores (p < 0.05). Nonetheless, no noteworthy association was observed between the serum cystatin D levels and sociodemographic data, rheumatoid factor (RF), and anti-cyclic citrullinated peptide (anti-CCP).

Conclusion
Cystatin D serum levels are higher in RA patients compared to healthy subjects and are strongly correlated with the activity of RA. It can be a valuable biomarker for evaluating RA disease activity.
Rare disease genomics and precision medicine
Authors: Hong Juhyeon , Lee Dajun , Hwang Ayoung , Kim Taekeun , Ryu Hong-Yeoul , Choi Jungmin 
Published: December 2024

AbstractRare diseases, though individually uncommon, collectively affect millions worldwide. Genomic technologies and big data analytics have revolutionized diagnosing and understanding these conditions. This review explores the role of genomics in rare disease research, the impact of large consortium initiatives, advancements in extensive data analysis, the integration of artificial intelligence (AI) and machine learning (ML), and the therapeutic implications in precision medicine. We also discuss the challenges of data sharing and privacy concerns, emphasizing the need for collaborative efforts and secure data practices to advance rare disease research.
Disparities in Utilization of Immune Checkpoint Inhibitor Therapy Among Older Patients With Advanced Non–Small Cell Lung Cancer: A SEER-Medicare Analysis
Authors: Yang Danting , Karanth Shama D. , Yoon Hyung-Suk , Yang Jae Jeong , Lou Xiwei , Bian Jiang , Zhang Dongyu , Guo Yi , Yaghjyan Lusine , Akinyemiju Tomi , Rodriguez Estelamari , Mehta Hiren J. , Braithwaite Dejana 
Published: December 2024

PURPOSE
In the United States, there are disparities in access to care for patients with non–small cell lung cancer (NSCLC) on the basis of socioeconomic and racial/ethnic factors. This study investigates the association between race/ethnicity and the utilization of immune checkpoint inhibitor (ICI) therapy among older patients with advanced NSCLC (aNSCLC).

METHODS
This retrospective study used data from the SEER-Medicare–linked database. The cohort included patients (age 66 years or older) diagnosed with aNSCLC (stage III/IV) between March 2015 and December 2017, and they were followed through December 2019. Race/ethnicity was categorized as non-Hispanic (NH)-White, NH-Black, Hispanic, and Other. ICI therapy utilization was determined by identifying any usage of ICI agents (nivolumab, pembrolizumab, atezolizumab, durvalumab, ipilimumab, and cemiplimab-rwlc) from the Medicare database. Multivariable logistic regression models assessed the association between race/ethnicity and ICI therapy utilization (yes, no). Effect measure modification analyses were conducted by sex, socioeconomic status, and comorbidity.

RESULTS
The final sample included 26,836 patients; 76.2% were NH-White, 10.1% NH-Black, 5.7% Hispanic, and 8.0% Other. The overall ICI therapy utilization proportion was 17.8%, varying across ethnicities: NH-Black 14.1%, Hispanic 16.3%, NH-White 18.4%, and Other 18.5%. In comparison with NH-White patients, NH-Black patients were 15% less likely to receive ICI therapy (adjusted odds ratio, 0.85 [95% CI, 0.75 to 0.96]). Furthermore, the association between race/ethnicity and utilization of ICI therapy was modified by comorbidity status, sex, and socioeconomic status.

CONCLUSION
NH-Black patients with aNSCLC were less likely to receive ICI therapy than their NH-White counterparts. Our findings indicate the racial/ethnic disparities in ICI therapy utilization and call for further interventions to optimize access to care.