bluuebunny/crossref_metadata_2025_split huggingface dataset:
KİŞİ ADLARI-SİYASAL EĞİLİM İLİŞKİSİ:MERSİN ÜNİVERSİTESİ ÖRNEĞİ
Authors: Altan Cemal 
Published: April 2018

Ad verme bireyin tanınmasını, diğer bireylerden
ayırt edilmesini sağlayan bir belirleyici unsur olduğu gibi, aynı zamanda ailelerin kültürlerinin sonraki
nesillere aktarılmasını sağlayan bir taşıyıcı aktördür. Ailelerin kültürü
dediğimiz de yine toplumun sahip olduğu değerler ve normlardır. Toplumlar sahip
oldukları kültürleri yaşatmak isterler. Yaşatmanın bir yolu da ad vermedir. Bu
yolla toplumlar, toplumsal dinsel ve tarihsel kültürleriyle birlikte siyasal
kültürlerini de ad verme yoluyla sonraki nesillere aktarmaya çalışırlar. Bu
nedenle de toplumların sahip olduğu değerler zamana ve mekana bağlı olarak
değiştiği için, kişi adları da zamana ve konjoktöre göre değişir. İçinde
bulunulan zaman dilimi ve sahip olunan kültürel değerler, adların verilmesinde önemli
rol oynar. Bir çok faktör gibi siyasal kültür de ad vermede etkili olmaktadır.
Aileler ve biraz daha geniş tutarsak toplumun sahip olduğu etkin ve baskın
siyasal değerler, ad vermede çok etkili olmaktadır. Örneğin, sevilen bir
siyasal kişiliğin adından etkilenilerek çocuklara ad verme, ya da bir partinin
değerlerini benimseyen bir ailenin o partinin önde gelen adlarını çocuklarında
yaşatmak istemesi çok karşılaşılan bir durumdur. Ayrıca partilerin savundukları
değerleri benimseyen aileler, çocuklarının da benzer kültürü devam ettirmesini
istedikleri için, o kültürde çokça kullanılan adları çocuklarına verme
eğilimindedirler.
Antibodies to myelin basic protein as a diagnostic marker of primary open-angle glaucoma
Authors: Cherednichenko Nina L. , Karpov Sergey M. , Baturin Vladimir A. , Barbos Yuliana A. 
Published: April 2018

Recently, many authors resort to immunomolecular diagnostics of glaucoma. We found conflicting information about the concentration of antibodies to the myelin basic protein (AB to MBP) in primary open-angle glaucoma in the literature.
Aim: to determine the concentration of antibodies to the myelin basic protein in the serum of patients with primary open-angle glaucoma to assess the diagnostic significance of the test.
Materials and methods. We included 48 people aged from 42 to 79 years: fourteen people had the diagnosis of the first stage of primary open-angle glaucoma (POAG), 10 people had the second (advanced) stage of POAG, 8 people had the III (far-gone) stage of POAG, and 16 subjects made the control group. Exclusion criteria: mature or almost mature cataract, age-related macular degeneration, severe concomitant ophthalmologic, neurological pathology, oncological and autoimmune diseases, glucocorticoid or immunosuppressive therapy, exacerbation of any acute and subacute respiratory infection, chronic inflammatory processes and craniocerebral trauma. The serum level of AB to MBP was determined by enzyme immunoassay method (ELISA).
Results. The concentration of AB to MBP was significantly higher in patients with first and second stages of POAG (177.5 63.93 g/ml and 262.63 34.78 g/ml, respectively) than in the control group (38.69 11.77 micron/ml, p 0.05). To establish the diagnosis of POAG in at risk patients it is appropriate to use the level of IgG to MBP 60 g/ml; the sensitivity of the method is 78% and its specificity is 87%.
The experience of the first Russian latanoprost 0.005% (Trilactan) use in the treatment of primary open-angle glaucoma
Authors: Tatarintseva Alla O. 
Published: April 2018

Summary. The problem of the reproduced (generic) and original (branded) medications coexistence on the pharmaceutical market is very relevant for Russia. Numerous polls have shown that very few among patients and even doctors clearly understand the differences between original drugs and generics, nor they know how these drugs are produced, and what advantages and weaknesses they have.
Aim. This paper covers the study of Trilactan (0.005% latanoprost, Solopharm, Russia) use in patients with different stages of primary open-angle glaucoma, and includes the analysis of the hypotensive effect and adverse events rate.
Material and methods. The study included 47 patients divided into 3 groups. The first group included 17 treatment-nave patients (32 eyes). The second group included 14 patients (28 eyes) previously treated with latanoprost 0.005% once a day in the evening at least for a month. The third group consisted of 16 patients (32 eyes) treated with beta-blockers or carbonic anhydrase inhibitors, in whom the target level of intraocular pressure had not been reached. All patients received 1 drop of Trilactan every evening; the observation lasted for 3 months.
Conclusions. The treatment was well tolerated. The intraocular pressure decrease was observed in all cases (p 0.05). Local and systemic adverse events under Trilactan treatment did not differ from possible side effects typical to the drugs of this pharmacological group in terms of its type and rate.
Emotional and behavioral problems in infants and preschool children: prevalence and sociodemographic risk factors
Authors: Uğur Çağatay , Yürümez Esra , Yılmazer Yasemin 
Published: April 2018

Objectives: To determine the prevalence of behavioral disorders and the relationship between sociodemographic, environmental and family factors among infants and preschool children applied to psychiatry clinic. Methods: The sample comprised 355 children between 20-59 months of age and showing normal developmental pattern. After psychiatric assessments, the patients were referred to the child development unit for developmental assessment, support and psychoeducation. Ankara Developmental Screening Inventory (ADSI) was applied to all participants. Results: The mean age was significantly higher among the children applied to the clinic due to limit setting problems (LSP) than that of the children applied due to the other problems. The children with speech delay were the group applied to the clinic at the earliest age. Speech delay rates were higher among boys compared with girls. Sibling jealousy was more common among girls than boys. In the group with LSP, fathers’ education levels were lower than that of the group without LSP. There was no difference between children in terms of the number of siblings, birth order and family size. Conclusion: The findings indicate that limit setting was by far the most common problem among children applied to our clinic. Consequently, the utility of results to raise intervention strategies within limit setting should be developed and intervened earlier.
Cerebral organoids: a promising model in cellular technologies
Authors: Shnaider T. A. 
Published: April 2018

The development of the human brain is a complex multi-stage process including the formation of various types of neural cells and their interactions. Many fundamental mechanisms of neurogenesis have been established due to the studying of model animals. However, significant differences in the brain structure compared to other animals do not allow considering all aspects of the human brain formation, which could play the main role in the development of unique cognitive abilities for human. Four years ago, Lancaster’s group elaborated human pluripotent stem cell-derived three-dimensional cerebral organoid technology, which opened a unique opportunity for researchers to model early stages of human neurogenesis in vitro. Cerebral organoids closely remodel many endogenous brain regions with specific cell composition like ventricular zone with radial glia, choroid plexus, and cortical plate with upper and deeper-layer neurons. Moreover, human brain development includes interactions between different brain regions. Generation of hybrid three-dimensional cerebral organoids with different brain region identity allows remodeling some of them, including long-distance neuronal migration or formation of major axonal tracts. In this review, we consider the technology of obtaining human pluripotent stem cell-derived three-dimensional cerebral organoids with different modifications and with different brain region identity. In addition, we discuss successful implementation of this technology in fundamental and applied research like modeling of different neurodevelopmental disorders and drug screening. Finally, we regard existing problems and prospects for development of human pluripotent stem cell-derived threedimensional cerebral organoid technology.
The search for microRNAs potentially involved in the selfrenewal maintaining of laboratory rat pluripotent stem cells
Authors: Sherstyuk V. V. , Medvedev S. P. , Ri M. T. , Vyatkin Y. V. , Saik O. V. , Shtokalo D. N. , Zakian S. M. 
Published: April 2018

Self-renewal of cultured pluripotent stem cells is a complex process, which includes multiple functional and regulatory levels. Transcription factors, their target genes, chromatin modifiers, signaling pathways, and regulatory noncoding RNAs are involved in the maintaining of self-renewal. Studies of molecular and genetic bases of maintaining self-renewal and pluripotency in cultured mammalian cells are important to understand processes in preimplantation embryogenesis and to develop efficient techniques to obtain pluripotent stem cell lines for experimental biology and medicine. MicroRNAs (miRNAs) play an important role in pluripotency maintaining and reprogramming. However, involvement of this class of noncoding RNAs and functions of individual molecules are poorly studied. The goal of this study was the search for the miRNAs potentially involved in the pluripotency maintaining and reprogramming of Rattus norvegicus cells. We analyzed the expression of miRNAs in rat embryonic stem cells, induced pluripotent stem cells and embryonic fibroblasts using bioinformatic methods and data obtained with next generation sequencing. The analysis of differential expression between groups of rat pluripotent cells and fibroblasts, and the analysis of experimentally confirmed target genes of differentially expressed known rat miRNAs revealed novel potential players of pluripotency maintaining and reprogramming processes. In addition, novel members of these processes were revealed among novel rat miRNAs. The use of bioinformatic and systems biology approaches is the first step, which is necessary for choosing candidates for the subsequent experimental studies. The results obtained substantially improve our understanding of the self-renewal regulation system of the laboratory rat, a popular biomedical object, and our knowledge about the system in mammals.
Polymorphism T3111C of the Clock gene in ethnic groups of women from Russia and Buryatia
Authors: Kaluzhnaya O. V. , Semenova N. V. , Bairova T. A. ,  Madaeva I. M. , Belyaeva E. V. , Kolesnikova L. I. 
Published: April 2018

Biological rhythms of organisms depend on both changing conditions of the external environment and internal “biological clock”. Circadian rhythms are the response of the organism to the change of day and night. They are some of the most important biological rhythms of organisms. Circadian rhythms are regulated by the group of circadian genes. It is known that women suffer from sleep disorders more often than men. Up to 50 % of menopausal women complain of problems associated with sleeping. The study involved 403 menopausal women aged from 45 to 60 years: 214 Russians (the average age is 52.74±6.28 years) and 189 Buryats (the average age is 51.95±5.13 years) living in Eastern Siberia (Irkutsk region, Irkutsk and Republic of Buryatia, Ulan-Ude). The prevalence of genotypes and alleles of the polymorphism T3111C of the circadian rhythm gene Clock (rs1801260) was studied in these groups. To this end, we conducted genotyping of DNA samples by polymerase chain reaction. It was shown that the compared groups have statistically significant differences in genotypes frequency (р = 0.001). It was found that in the group of Russian women the frequency of the TC genotype (p = 0.004) was significantly higher and the frequency of the TT genotype (p = 0.0001) was significantly lower than those in the sample of women of Buryatia. It was shown that in the group of Russian women allele 3111C is found in 30.4 % of cases, which is statistically significantly more often than in the group of Buryat women, where the frequency of allele 3111C was 19.3 % (p = 0.014).
Hippocampal glucocorticoid receptor and microRNA gene expression and serum cortisol concentration in foxes selected for behavior toward humans
Authors: Ovchinnikov V. Yu. , Antonov E. V. , Vasilyev G. V. , Shihevich S. G. , Shepeleva D. V. , Herbeck Yu. E. 
Published: April 2018

In many cases, stress reactivity is one of the important bases of aggressive behavior. It appears as if reduced stress reactivity underlies an abrupt decrease in aggression towards man in domesticated animals. However, the mechanisms of this reduction have yet to be resolved. In this work, we used an experimental domestication model, the silver fox selected for many years for the response to humans to study cortisol stress reactivity in tame and aggressive foxes in response to immobilization in human arms. Additionally, these behavioral fox groups were explored for one of the important mechanisms of glucocorticoid negative feedback, the expression of the glucocorticoid receptor gene (NR3C1) in a portion of the dorsal hippocampus. In recent years, attention has been paid to differences in miRNA expression patterns between animals with different behavior and stress reactivity, as well as to miRNA regulation under stress. The same applies to NR3C1 mRNA as well. That is why we performed a miRNA-seq analysis on a portion of the fox dorsal hippocampus. It has been demonstrated that immobilization in human arms leads to significantly higher stressinduced cortisol levels in aggressive than tame foxes. At the same time, no differences have been found between hippocampal NR3C1 gene expression and the pattern of miRNA expression. Thus, reduced stress reactivity in foxes during selection for the absence of aggressive responses and for the presence of emotionally positive responses to humans does not seem to be associated with important mechanisms of regulation such as alterations in hippocampal NR3C1 gene expression or microRNA-mediated silencing.
Impact of glycolysis inhibitor (2-DG) and oxidation and phosphorylation uncoupler (2,4-DNP) on brain metabolites
Authors: Shevelev O. B. , Moshkin M. P. 
Published: April 2018

Deviations in brain metabolism are the result of longterm pathological processes, which finally are manifested as symptoms of Parkinson’s or Alzheimer’s diseases or multiple sclerosis and other neuropathologies, as for example diabetic neuropathy. A deficiency of available energy for brain cells under neurodegenerative diseases is either developed due to age-dependent underexpression of genes that encode glycolytic enzymes or induced due to the uncoupling of oxidation and phosphorylation that could be mediated by inflammatory cytokines. Since the activity of many enzymes is under the control of adenosine triphosphate (ATP) or cofactors, such as nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH), energy deficiency can cause metabolic changes in brain tissue. Some clinical studies using proton nuclear magnetic resonance spectroscopy (1H NMR spectroscopy) revealed metabolic changes in brain tissue in patients with neurodegenerative diseases. However, data from different authors are quite contradictory, probably because of the complex genesis of metabolic disorders. In the present study, we tested the hypothesis of multidirectional changes in metabolism under the impact of the oxidation and phosphorylation uncoupler 2,4-dinitrophenol (2,4-DNP) and under the impact of 2-deoxy-Dglucose (2-DG), blocking the access of glucose to the brain cells. 1H NMR spectroscopy showed that 2-DG leads to the predominance of excitatory (glutamine + glutamate) neurotransmitters over inhibitory ones (gamma-aminobutyric acid), and 2,4 DNP causes opposite effects. The biochemical mechanisms of the observed changes require a special study, but it can be noted that the ATP deficiency caused by inhibition of glycolysis and the ATP deficiency caused by the uncouplers are accompanied by differently directed changes in the intensity of the tricarboxylic acid cycle. These changes in the intensity of the Krebs cycle are correlated with differently directed changes in the balance of the exciting and inhibitory neurotransmitters. The obtained results show that 1H NMR spectroscopy can be an effective method of differentiated lifetime assessment of the available energy deficit caused by a general suppression of energy exchange in nerve cells or oxidation and phosphorylation uncoupling.
Antisense oligonucleotides for the arterial hypertension mechanisms study and therapy
Authors: Klimov L. O. , Seryapina A. A. , Zarytova V. F. , Levina A. S. , Markel A. L. 
Published: April 2018

Arterial hypertension is one of the most common chronic diseases in adults all over the world. This pathology can not only reduce patients’ life quality, but can also be accompanied by a number of complications. Despite the fact that there is a large group of antihypertensive drugs on the market, mainly representing different combinations of inhibitors of the renin-angiotensin system, adrenoreceptor blockers in combination with diuretics, there is no generally accepted “gold standard” for drugs that would not have side effects. The review discusses the main aspects of antisense oligonucleotides use in the context of arterial hypertension. It is well known that the medical implementation of antisense oligonucleotides aims to block the expression of particular genes involved in the pathology development, and a key advantage of this technique is a high selectivity of the effect. However, with the undoubted advantages of the method, there are difficulties in its application, related both to the properties of the oligonucleotides themselves (insufficient stability and poor penetration into cells), and to the variety of mechanisms of the origin of a particular pathology, arterial hypertension, in our case. The review provides a brief description of the main molecular targets for antisense treatment of hypertensive disease. The newest targets for therapy with oligonucleotides – microRNAs – are discussed. The main modifications of antisense nucleotides, designed to increase the duration of their effects and simplify the delivery of this type of drugs to the targets are discussed, in particular, combining antisense oligonucleotides with adenovirus-based expression vectors. Particular attention is given to antisense oligonucleotides in the complex with nanoparticles. The review discusses the results of the use of titanium dioxide (TiO2) containing antisense nanocomposites for the angiotensin converting enzyme in rats with stress induced arterial hypertension (ISIAH). It was shown that the use of antisense oligonucleotides continues to be a promising technique for studying the mechanisms of various forms of hypertensive disease and has a high potential for therapeutic use.
Influence of the biologically active dietary supplement Floravit® on the skin and hair structure in sable (Martes zibellina)
Authors: Loenko N. N. , Chernova I. E. , Kunitsina T. S. 
Published: April 2018

It is important to search for new highly effective multicomponent compounds that are able to influence several of animals’ homeostasis systems simultaneously to improve the physiological adaptation of fur animals to different conditions of nutrition. This is the function of the feed additive Floravit® – a natural bioregulator. The compound is a combination of biologically active ingredients produced by the mycelial fungus Fusarium sambucinum. Studied was the effect of Floravit® on the structure of the skin and hair in adult female sable (Martes zibellina). The scientific and economic experiment was conducted at the JSC “Plemzavod Pushkinskyi” in the Moscow Region during the period of winter fur formation in October-November. The study of the morphological structure of the hair and skin cover was carried out in the chine, side and rump topographical areas. The structure of the guard hairs in the main topographical areas was examined on a scanning electron microscope. The experiment showed that administration of Floravit® per os to adult female sable at a dose of 1.0 ml per head per day throughout the period of winter pelt formation in October-November has an influence on the morphological structure of all the categories of hair on all topographic pelt areas. Animals in the test group exposed to Floravit® exhibited an increase in guide hair length on the chine and side, when compared to controls, by 4.1 mm (p < 0.001) and by 2.8 mm (p < 0.01), respectively. The length of guard hair on the chine, side and rump increased by 8.1, 7.8 and 7.8 mm (p < 0.001), respectively. An increase in down hair length was recorded in all areas of the pelt, when compared to controls, by 13.0, 4.5 and 6.3 mm (p < 0.001). An increase in dermal thickness was recorded in the chine area by 0.7 mm (p < 0.001). The specified changed in the skin and hair structure in sable adult females after using Floravit® have shown a positive influence on the quality of hair cover. As a result, bioregulator Floravit® takes part in the adaptation process of the sable organism to external factors.
The Correlation of Occupational Stress With Subjective Fatigue Women Workers In Weaving Loom Unit PT. X
Authors: Andarini Yulia Dwi , Eka Prasetya Tofan Agung 
Published: April 2018

Background : An occupation with a high risk of work fatigue is an occupation in textile industry. The involvement of women in the textile industry sector in Indonesia is dominant. Women labors who run work on domestic and public sector will be less inclined a work fatigue. Subjective fatigue is the problem faced by women workers at production division weaving loom unit of PT. X. Purpose : This study aimed to determine occupational stress correlation with subjective fatigue in weaving loom unit PT. X. Methods : Type of this observational analytic study was using a cross sectional design. The number of research subject were 95 people. An occupational stress is independent variable. The dependent variable is a subjective fatigue. Occupational stress measurement was using job stress indicator questionnaire. Subjective fatigue measurement was using Subjective Self Rating Test questionnaires. Chi square test used as significance test. All test used 95% confidence interval and significance level of p=0,05. Result : Chi square test result showed that occupational stress has significant association with subjective fatigue. Conclusion : An occupational stress has a positive correlation with subjective fatigue women workers in weaving loom unit PT. X.