bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED ARTICLE: Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis
Authors: Zhang Xing , Li Zheng , Xuan Zhe , Xu Penghui , Wang Weizhi , Chen Zheng , Wang Sen , Sun Guangli , Xu Jianghao , Xu Zekuan 
Published: December 2018

Abstract
Background
Autophagy plays a crucial role in sustaining the homeostasis in various malignant diseases. It has also been reported to promote tumor development in multiple cancers. Glutaminolysis instead of Warburg Effect produce adequate ATP and provide nitrogen and carbon to replenish the TCA cycle which has been discovered to be a new energy source for tumor cells recently. By means of degrading intracellular particles including amino acids, nucleotides, fatty acids, sugars and aged organisms, autophagy can recycle the aforementioned particles into bioenergetics and biosynthesis pathways, finally favoring tumor cells. MicroRNA is a kind of noncoding RNA that regulates the targeting gene expression mostly at post-transcription level. Among these miRNAs, microRNA-133a-3p is reported to be a tumor suppressor in numerous cancers.

Methods
We characterized the down-regulated expression level of microRNA-133a-3p in gastric cancer via TCGA database. Subsequently, we verified the tumor suppressor role of microRNA-133a-3p in gastric cancer cells through a series biological function assay. We used immunofluorescence and transmission electron microscope to observe the negative effect of microRNA-133a-3p on autophagy and used dual-luciferase report assay to identify the candidate gene GABARAPL1 of microRNA-133A-3p.Then we used high performance liquid phase mass spectrometry and seahorse analysis to detect whether miR-133a-3p could block the glutaminolysis metabolism through autophagy. At last, we confirmed the tumor suppressor role of microRNA-133a-3p in vivo on PDX mice model.

Results
We demonstrated that microRNA-133a-3p overexpression could block the activation of autophagy to ruin the abnormal glutaminolysis and further inhibit the growth and metastasis of gastric cancer cells. We successfully proved gastric cancer cells can replenish glutaminolysis via autophagy and microRNA-133a-3p could block aforementioned pathway by targeting core autophagy participants GABARAPL1 and ATG13.We then verified the negative function of microRNA-133a-3p on autophagy-mediated glutaminolysis both in PDX model and human gastric cancer organoid model.

Conclusions
MicroRNA-133a-3p targets GABARAPL1 to block autophagy-mediated glutaminolysis, further repressing gastric cancer growth and metastasis.
Ink marks, bronze crossbows and their implications for the Qin Terracotta Army
Authors: Bevan Andrew , Li Xiuzhen , Zhao Zhen , Huang Jianhua , Laidlaw Stuart , Xi Na , Xia Yin , Ma Shengtao , Martinon-Torres Marcos 
Published: December 2018

Abstract
At the heart of bureaucratic practice during Warring States and early Imperial China were regular, small acts of accountancy in which objects and people were marked so that their movements could be kept track of, their quality checked and their numbers marshalled. In the mausoleum complex of the Qin Shihuang (259-210 bc, the First Emperor of the Qin Dynasty), the longer texts and shorter inscribed marks found on the bronze weapons of the Terracotta Army are reasonably well known, and such information helps us to understand aspects of Qin craft organisation and logistics at this crucial period of Chinese state formation. This paper’s modest starting point is a study of two further, less well-known ink inscriptions found on crossbow triggers from Terracotta Army Pit 1. Using multispectral photography, digital microscopy and Raman analysis, we uncover evidence of further marks on the same two triggers that suggest a similar pattern of ‘matching’ marks as suggested by the incised evidence. We also identify the black substance used to make the marks as a soot-based ink. Spatial analysis of both the inked and incised trigger marks then provides wider context for how such marking practices amongst Qin bronze-workers may have operated.
The effect of Hydrodistension in combination with Pentosan Polysulfate on treatment outcomes and compliance in the treatment of bladder pain syndrome
Authors: Şimşir Adnan , Kızılay Fuat , Özyurt Ceyhun 
Published: December 2018

Objective: In the present study, we investigated the efficacy of bladder hydrodistension combined with pentosan polysulfate (PPS) treatment in interstitial cystitis (IC)/bladder pain syndrome (BPS).
Methods: In this study, 339 patients diagnosed with IC/BPS were categorized into two groups. The first group only received 300 mg/day PPS, while the second group received 300 mg/day PPS following bladder hydrodistension. The results were evaluated at the 3rd, 6th, and 12th months after the first dose using the interstitial cystitis symptom index (ICSI), international cystitis problem index (ICPI), visual analog scale (VAS), and female sexual function index (FSFI).
Results: PPS treatment started just after hydrodistension was significantly more effective than PPS treatment alone and combined treatment significantly reduced the rate of non-compliance such that, at the end of the 3rd month, 12.1% patients in Group-1 did not continue their treatment whereas only 1.9% of patients in Group-2 did not continue.
Conclusions: The study results indicate that PPS treatment started just after hydrodistension yields significantly better results in terms of both symptom improvement and treatment compliance in patients with IC/BPS.
How to cite this:Simsir A, Kizilay F, Ozyurt C. The effect of Hydrodistension in combination with Pentosan Polysulfate on treatment outcomes and compliance in the treatment of bladder pain syndrome. Pak J Med Sci. 2019;35(1):189-194. doi: https://doi.org/10.12669/pjms.35.1.172
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Why doctors are not satisfied with their job current status in tertiary care hospitals
Authors: Ali Faiza Sadaqat , Zuberi Bader Faiyaz , Raheed Tazeen , Shaikh Majid Ahmed 
Published: December 2018

Objective: To determine level and factors of job satisfaction among doctors working in tertiary care hospitals in Pakistan.
Methods: This is a multi-center cross-sectional survey conducted among Post graduate trainees, medical officers, consultants and faculty doctors. Job satisfaction was measured using 35 specific questions about sources of work-related stress and sources of work-related satisfaction. Satisfaction was defined if mean score of a factor was ≥3.0, where factors were rated using a 5-point Linkert scale ranging from 1 (completely dissatisfied) to 5 (completely satisfied).
Results: In this study 373 doctors participated, out of which 215(57.6%) were males. Over all mean satisfaction score was of 2.69±0.37. Departmental mean satisfaction scores were Internal medicine 2.71±0.35, Medical subspecialties 2.63±0.38, Surgical and allied 2.73±0.45. Designation means were Consultant 2.87±0.38, Faculty 2.78±0.44, Medical officer/Registrar 2.50±0.32, Post graduate trainee 2.71±0.45. Public and private sector means satisfaction scores were 2.53±0.80 and 2.92 ±0.84 respectively.
Conclusion: Job dissatisfaction was seen among doctors from all the tiers and departments. Public sector doctors were more dissatisfied than private sector doctors. Increasing age, duration of current posting and working experience, positively correlated with satisfaction level.
How to cite this:Ali FS, Zuberi BF, Rasheed T, Shaikh MA. Why doctors are not satisfied with their job-current status in tertiary care hospitals. Pak J Med Sci. 2019;35(1):205-210. doi: https://doi.org/10.12669/pjms.35.1.72
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Simulating Siberian Radioheliograph response to the quiet Sun
Authors: Лесовой Сергей , Lesovoi Sergey , Кобец Вероника , Kobets Veronika 
Published: December 2018

The Siberian Radioheliograph (SRH) correlation plot is the time dependence of the sum of absolute values of complex correlations over all baselines. These plots are built for each operating frequency of SRH. The correlation is related not only to the spatial coherence of the incident microwave emission but also to antenna gains. That is why we have to consider real SRH antenna gains and shadowings. Correlation plots obtained by SRH are related to microwave flux density of the Sun and spatial features of microwave sources. Also the correlation plots show variability of SRH beam pattern in time with constant flux density and spatial structure of sources. The SRH beam pattern depends on position of the Sun with respect to SRH, which changes with time. This leads to variations of these plots, which can be confused, for example, with the quasi-harmonic oscillations of the microwave flux produced by sources located above sunspots. Because the solar disk is an extended source, the correlation plot variability is mostly due to the SRH response to the quiet Sun. The smaller is the microwave source, the smaller are the correlation plot variations caused by a change of the beam pattern. Relatively fast variations result from long baseline responses, so it is undesirable to exclude them from the plots. Moreover, the sensitivity of the plots is better when all baselines are taken in account. The impact of the correlation plot variations on the eruptive event response is especially strong because variations of microwave flux during such events are comparable with those of the correlation plots in magnitude and time. From the above it seems reasonable to simulate the SRH response to the quiet solar disk and correct the correlation plots.
In this work, we propose a method for simulating correlation plots, which allows us to correct their variations caused by time and frequency dependence of SRH response to the solar disk. The correlation plots are simulated either by summing all model antenna pair responses to the model solar disk or by summing the corresponding values of the solar disk visibility under the assumption that the visibility is ~J1(x)/x, where J1(x) is the Bessel function of the first kind. Also we consider the shadowing of antennas nearest to the center of the SRH antenna array.
Selected psychiatric and environmental factors
influencing the incapacity to work in the police force
in relation to gender
Authors: Krzemiński Sławomir , Florkowski Antoni 
Published: December 2018

Aim of the studyTo evaluate the causes of incapacity for further service in the Police of women and men due to health issues and show any differences related to gender.Subject or material and methodsAnalysis of certification and medical records of 130 patients with documented mental disorders, who require more than 5 years of psychiatric treatment. This research uses a structured sociodemographic and medical questionnaire designed specifically for this project.ResultsThe mean age of the studied group was 48 for women and 44 for men. Seniority of woman was mostly 21 to 25 years and more than 25 years, whereas seniority of men between 21 and 25 years. The period of treatment in psychiatric health clinics was longer for women. The most common cause for incapacity for work were chronic neurotic disorders amounting to 87.69% of women and 98.41% of men.DiscussionDifficulties in the professional functioning of members of uniformed services, which suffered from neurotic disorders causing incapacity for further service was documented in the literature.ConclusionsThe results of this research indicate, that in the analyzed population of police officers the main cause of incapacity for work were chronic neurotic neurasthenic disorders. Seniority as well as age of the police officers retiring from the Police force was higher in women. Neurotic disorders often coexisted with somatic disorders, among which were hypertension and degenerative disorders of the spine. Neurotic and neurasthenic disorders qualified the examined individuals to the third invalidity group due to serving in the Police.
Prevalence of alcohol use disorders in hospitalised male patients
Authors: PATEL DR. TEJAS , BRAHMBHATT DR. MEHUL , VANKAR DR. GANPAT 
Published: December 2018

Aim of the studyTo find out prevalence of Alcohol Use Disorders (AUD) among hospitalized patients at a tertiary care centre in Medical, Surgical and Orthopaedic trauma wards.Subject or material and methods: It is prospective, randomized, cross-sectional study at a tertiary hospital in a state with prohibition policy. Patients hospitalized in Medical, Surgical and Orthopaedic trauma wards (n=150 in each ward) were screened for AUD by using Alcohol Use Disorder Identification Test(AUDIT). Psychiatrist evaluated them as per DSM IV TR criteria. Case records were examined for mention of AUD by the treating physician. Chi square test, and two tailed t test were applied appropriately. p<0.05 was considered as indicative of statistically significant difference.ResultsAs a whole prevalence of AUD was 16.9 % as per DSM IV TR criteria (Medical in-patients, 22%, surgical in-patients, 16%, Orthopaedic in-patients,12.7%). AUDIT had sensitivity 86.8%, specificity, 95.9%, overall accuracy 94.4%.DiscussionAUD is prevalent in at least one fifth hospitalized patients in a state with prohibition policy. They were poorly recognized by treating physicians. Simple screening by AUDIT scale when routinely used may increase detection of AUD.ConclusionsAlcohol Use Disorders (AUD) are common among medically ill indoor patients. However due to various reasons the AUD are not detected, hence an opportunity to intervene is wasted.
Effect of selenium as an adjunctive therapy
in patients with treatment-resistant
obsessive-compulsive disorder:
A pilot randomized double blind
placebo-controlled clinical trial
Authors: Sayyah mehdi , Andishmand Mina , Ganji Reza 
Published: December 2018

Aim of the studyThe first line medicinal treatment of Obsessive Compulsive Disorder includes Selective Serotonin Reuptake Inhibitors (SSRIs).Researchers have shown that there is a correlation between the trace elements deficiency such as selenium and mental disorders and mood, since selenium is a safe and non-tolerable side-effect supplementation that may be useful as an adjunctive treatment with SSRIs.Subject or material and methodsThirty-two patients with a treatment-resistant obsessive-compulsive disorder were selected and randomly entered into two groups: intervention and control, while both groups continued to consume SSRI drugs according to the current procedure. The intervention group received one 200 mcg selenium capsule daily and each daily control group received one capsule of placebo for 6 weeks.ResultsY-BOCS scores decreased at the end of the sixth week in both groups, but this reduction was significantly lower in the selenium group (P = 0.01). Selenium was well tolerated and there was no significant difference between the two groups in the incidence of side effectsDiscussionThe results of this study indicate that selenium as an adjunctive treatment with SSRIs improves symptomsConclusionsSelenium can be as new drug for treatment of Refractory OCD.
Palliative care in dementia: a fragmented pathway?
Authors: Dening Karen Harrison , Scates Caroline , Lloyd-Williams Mari 
Published: December 2018

Background: Most deaths occur in people over the age of 65 years, yet there is widespread evidence that older people have inequitable access to good palliative and end-of-life care. For people with dementia, there are further barriers to receiving palliative care. Identifying when older people with dementia are reaching the end of their lives is not straightforward. A palliative approach to care has been recognised as key in UK practice guidance; the National Institute of Health and Care Excellence recommends that, from diagnosis, people living with dementia should be offered flexible, needs-based palliative care that takes into account how unpredictable dementia progression can be. However there are still wide gaps in care in the dementia pathway, largely because commissioning is fragmented. Method: This paper describes the Admiral Nurse case management approach to palliative care by benchmarking its practice against the European Association of Palliative Care white paper recommendations for palliative care in dementia.
Medicine and health technology in 2018
Authors: Kerstein Ryan 
Published: December 2018

2018 was a pretty big year for medicine and health technology. A new Health Secretary took over the political reins and reshaped the agenda ‘to revolutionise the NHS with new technology’. The RCS established the Commission on the Future of Surgery to set out a compelling vision for the future of our practices, and 2018 also reportedly saw an artificial intelligence system pass the RCGP’s clinical knowledge test (MRCS is safe so far). To look back over the past 12 months and comment on the year ahead, we have collected the opinions of some of the leading clinicians and corporate experts across healthcare. We asked each what they thought made the biggest impact in 2018 and what excited them looking forward to 2019 and beyond.
An empirical approach for software reengineering process with relation to quality assurance mechanism
Authors: Muzammul Muhammad , Awais Muhammad 
Published: December 2018

Software development advances focus on productivity of existing software systems and quality is the basic demand of every engineering product. In this paper, we will discuss the complete re-engineering process with aspects of forwarding, reverse and quality assurance mechanism. As we know the software development lifecycle (SDLC) follows a complete mechanism of the engineering process. In forward engineering, we tried to follow selective main phases of software engineering(data,requirements, design, development, implementation).In reverse engineering, we move backward from the last phase of developing the product as it gathers requirements from the implemented product(implementation, coding, design, requirements, data). During reengineering, we add up more quality features on customer demands, but the actual demand is to fulfill quality needs that can be assured by external as well as internal quality attributes such as reliability, efficiency, flexibility, reusability, and robustness in any software system. We discussed a methodological approach to move from re-engineering to the journey of quality assurance. More than 50 studies come into discussion and throughput results proposed by graph and tabular form. We can say if the re-engineering process produces quality attributes, then it can be said by old software system refactoring as code refactoring, data refactoring and architectural refactoring we obtained a quality product at a lower cost instead of new software system development, which causes a decrease in quality attributes as cost, time etc. In future work, testing methodology can be proposed for quality assurance.
Interacción entre la extensión y la investigación–acción para el abordaje de una problemática en el sector productivo marplatense
Authors: Ambrústolo Mariela 
Published: December 2018

El presente escrito tiene por objeto describir el trabajo de investigación–acción del Grupo de investigación y extensión “Mejora Continua, Calidad y Medio Ambiente”.
El proyecto se centró en la aplicación de una herramienta básica de gestión que permite preparar a las organizaciones que pretendan implementar sistemas de gestión de la calidad y mejorar sus lugares de trabajo. El mismo fue desarrollado en tres períodos a través de talleres de extensión brindados a empresas representativas del sector industrial marplatense y en los cuales se contó con la participación de estudiantes avanzados.
La extensión en el ámbito universitario es un mecanismo de construcción de capacidades, desarrollos tecnológicos, capacitación en diversos sectores sociales, productivos públicos o privados. La construcción de conocimiento resultó un elemento fundamental para el desarrollo del proyecto de investigación que abordó el estudio de las modalidades, estrategias, ventajas y obstáculos que se presentan en la aplicación de estas herramientas.
A uniqueness result for differential pencils with discontinuities from interior spectral data
Authors: Khalili Yasser , Baleanu Dumitru 
Published: December 2018

Abstract
In this work, the interior spectral data is employed to study the inverse problem
for a differential pencil with a discontinuity on the half line. By using a set of values of the eigenfunctions
at some internal point and eigenvalues, we obtain the functions

q
0

⁢

(
x
)

{q_{0}(x)}

and

q
1

⁢

(
x
)

{q_{1}(x)}

applied in the diffusion operator.
Regularized Regression for Reserving and Mortality Models
Authors: Venter Gary 
Published: December 2018

Abstract
Bayesian regularization, a relatively new method for estimating model parameters, shrinks estimates towards the overall mean by shrinking the parameters. It has been proven to lower estimation and prediction variances from those of MLE for linear models, such as regression or GLM. It has a goodness-of-fit measure, and can readily be applied using available software. This can be used for any type of actuarial linear modeling, but it is slightly more complicated for mortality and loss reserving models that use row, column, and diagonal effects for array data. These are called age-period-cohort, or APC models by statisticians. The problem is that the row, column and diagonal effects are not what should be shrunk. These models can easily become over-parameterized, and actuaries often reduce parameters with smooth curves or cubic splines. We discuss an alternative smoothing method that uses regularization, with its reduction in estimation errors, and illustrate both its classical and Bayesian forms and their application to APC modeling. Typical actuarial models and some generalizations are used as examples.
The seaweed resources of Chile over the period 2006–2016: moving from gatherers to cultivators
Authors: Camus Carolina , Hernández-González María del Carmen , Buschmann Alejandro H. 
Published: December 2018

AbstractChile, located in the southeastern Pacific, possess a high richness of seaweed species, some of which have been traditionally extracted from natural beds for the production of hydrocolloids (e.g. agar, carrageenan and alginates), but still a high proportion of the biomass is being exported as dried material to processors in Asia and Europe. During the period 2006–2016, this tendency has been maintained, but has also started to show signs of changing towards a more sustainable, localized seaweed industry as new actions by the Chilean government provided subsidies to seaweed farming activities and also to investments in local valorization of the resources. This “sea change” has been further supported by an increase in the number of localized scientific and technical studies related to Chilean seaweed resources which has prepared the foundation required in order to move to more advanced stages of local seaweed farming and development of local processing.