bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury
Authors: Grigorieva Irina V. , Oszwald Andre , Grigorieva Elena F. , Schachner Helga , Neudert Barbara , Ostendorf Tammo , Floege Jürgen , Lindenmeyer Maja T. , Cohen Clemens D. , Panzer Ulf , Aigner Christof , Schmidt Alice , Grosveld Frank , Thakker Rajesh V. , Rees Andrew Jackson , Kain Renate 
Published: August 2019

Significance Statement
Mesangial cells play a crucial role in maintaining glomerular homeostasis and injuries to these cells often result in progression to CKD like IgA and diabetic nephropathies. However, the transcription factors involved in mesangial cell development and function are largely unknown. The authors describe the role transcription factor GATA3 plays in mesangial cells in embryonic kidneys and healthy and injured adult glomeruli. Mice with haploinsufficiency of GATA3 have too few MC precursor cells and glomerular abnormalities. GATA3 expression increases in mesangial cells in mesangial proliferative GN in humans and rodent models suggesting GATA3 is important for glomerular homeostasis and response to injury. GATA3 also may be a useful a nuclear marker of human mesangial cells.

Background
GATA3 is a dual-zinc finger transcription factor that regulates gene expression in many developing tissues. In the kidney, GATA3 is essential for ureteric bud branching, and mice without it fail to develop kidneys. In humans, autosomal dominant GATA3 mutations can cause renal aplasia as part of the hypoparathyroidism, renal dysplasia, deafness (HDR) syndrome that includes mesangioproliferative GN. This suggests that GATA3 may have a previously unrecognized role in glomerular development or injury.

Methods
To determine GATA3’s role in glomerular development or injury, we assessed GATA3 expression in developing and mature kidneys from Gata3 heterozygous (+/−) knockout mice, as well as injured human and rodent kidneys.

Results
We show that GATA3 is expressed by FOXD1 lineage stromal progenitor cells, and a subset of these cells mature into mesangial cells (MCs) that continue to express GATA3 in adult kidneys. In mice, we uncover that GATA3 is essential for normal glomerular development, and mice with haploinsufficiency of Gata3 have too few MC precursors and glomerular abnormalities. Expression of GATA3 is maintained in MCs of adult kidneys and is markedly increased in rodent models of mesangioproliferative GN and in IgA nephropathy, suggesting that GATA3 plays a critical role in the maintenance of glomerular homeostasis.

Conclusions
These results provide new insights on the role GATA3 plays in MC development and response to injury. It also shows that GATA3 may be a novel and robust nuclear marker for identifying MCs in tissue sections.
El turismo 2.0. Un nuevo modelo de promoción turística
Authors: Sánchez Amboage Eva 
Published: August 2019

Como consecuencia del empleo masivo de Internet el perfil del cliente ha cambiando, llegando a convertirse en lo que los entendidos llaman “Adprosumer”. Se unen en este término distintos conceptos: AD (anuncio), PRO (productor), SUMER (consumidor). Es esta una forma de resumir al nuevo cliente de la Web 2.0, el que recomienda, participa de la promoción y consume un producto. Ante este nuevo vocablo y nuestro interés por el sector turístico nos hacemos las siguientes cuestiones ¿Están las empresas turísticas adaptándose a este nuevo cliente? ¿Han cambiado su forma de promocionar los servicios turísticos? ¿Cómo influye el 2.0 en el sector turístico?A lo largo del presente artículo intentaremos contestar a estas interrogaciones a través del análisis del Turismo 2.0.
El procesamiento de la información de las personas mayores y su actitud hacia el anuncio
Authors: Estrada M. , Sánchez J. , Fandos J.C. 
Published: August 2019

El envejecimiento poblacional es un hecho de gran transcendencia socioeconómica con importantes repercusiones empresariales. Es importante el análisis del consumidor mayor y de sus particularidades para la consecución de una efectiva comunicación publicitaria. En este trabajo se analizan los antecedentes de la actitud ante el anuncio de las personas mayores y sus consecuencias sobre la actitud hacia la marca y la intención de compra en condiciones de baja implicación con el anuncio. Sobre una muestra constituída por 509 sujetos se confirma el modelo general planteado y se defiende que las personas mayores utilizan conjuntamente las dos rutas de persuasión en el procesamiento cognitivo del anuncio.
Inducing Expression of the BAS1 Gene via the SAG12 Promoter to Delay Flower and Plant Senescence in Transgenic Petunia hybrida
Authors: YAO Xinzhuan , Lu Litang , ZHAO Degang 
Published: August 2019

Abstract
Background: Brassinosteroids (BRs) are essential hormones that play crucial roles in plant growth, reproduction and response to abiotic and biotic stress.
Results: In transgenic Petunia hybrida , resulting in short stature, dark green leaves, and slowed aging.We demonstrate that the exogenous expression of the SAG12-BAS1 gene results in delayed senescence of flowers. SAG12-BAS1 transgenic lines, grown in the vegetative state, exhibited a range of phenotypic changes, including dark green leaves, short stature, delayed senescence, increased flower bud counts, branching, reduced internode lengths, and delayed flowering. SAG12-BAS1 transgenic expression increased the activity of protective enzymes, reduced malondialdehyde content, and increased chlorophyll content and soluble sugar accumulation in plants. Expression of senescence genes was increased in the transgenic Petunia hybrida compared to wild-type plants.
Conclusions: Our finding suggests that BAS1 could be used as a potential candidate gene regulate plant flower senescence and prolong flower longevity.
The Role of Orthodontics in the Management of Obstructive Sleep Apnea OSA in Children: Systematic Review
Authors: Alotaibi Norah , alkhamees Amani , Bilal Rabia 
Published: August 2019

Abstract
Objective

review the effectiveness of the use of different orthodontic oral appliance as a primary or adjective treatment of OSAS in children. methods: systemic search of online databases (PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), international Registry Platform for ongoing trials and clinical trails.gov, Embase Ovid, Medline complete) for randomized control trail and non-randomized prospective or retrospective clinical studies published in 2000-2019 that uses oral appliances for the treatment of OSA in children. Study selection was done by 2 reviews.

Results

9 studies were included in the review. Based on the limited evidence oral appliances improve OSA in children measured by the reduction of AHI. Due to heterogeneity of included study designs and reported data meta-analysis was not possible.

Limitation

limited number of studies and study populations. High risk of bias.

Conclusion

oral appliances show a promising improvement in AHI and should be considered as a treatment option for OSA in children
Post Outbreak Evaluation Of One Health Integrated Interventions Of Rift Valley Fever And Crimean Congo Haemorrhagic Fever In Kiboga And Kiruhura Districts, Uganda
Authors: Kungu Joseph Morison , Nsamba Peninah , Wejuli Alfred , Kabasa John D , Bazeyo William 
Published: August 2019

Abstract
Objective: Following containment of Rift Valley Fever (RVF) and Crimean Congo Hemorrhagic Fever (CCHF) outbreaks, a post evaluation of the use of a one health approach in management of the reported viral haemorrhagic fevers was conducted in the affected districts of Kiboga and Kiruhura districts in Uganda. This was done through a cross sectional study using participatory epidemiology tools, mainly observation and key informant interviews. Results: The findings indicated that the interventions employed had been successful in the management of the outbreaks and multidisciplinary approach enabled containment of these hemorrhagic fever outbreaks in the districts. Although the outbreaks had been contained, delays could have been minimized by undertaking laboratory diagnosis at district level instead of transporting samples to national referral laboratories in Entebbe. Response to the RVF and CCHF challenge could have been delayed by dependence on funding of central government and non governmental organizations due to failure to plan and allocate funds for surveillance and mitigation of diseases outbreaks at district local government levels.
Knowledge, Attitude, Practice and associated factors on menstrual hygiene among high school students of North Wollo Zone, Ethiopia, 2019: A cross-sectional study
Authors: Gedefaw Getnet , Endalew Fentanesh , Azmeraw Bitewsh , Walelign Bethelhem , Shitie Eyob 
Published: August 2019

Abstract
Objective Lack of proper menstrual hygiene predisposes women to different infectious and chronic obstetric and gynecological problems. A Facility based cross-sectional study was implemented from October 1- December 10, 2018. The data was collected using structured, pretested questioners among female high school students. Systematic random sampling technique was implemented. Data was entered and analyzed through Epi data 3.1 and SPSS respectively. Therefore, this study aimed to assess knowledge, attitude, practice and its associated factors of menstrual hygiene among high school students in North Wollo Zone, Woldia, Ethiopia. Results This study revealed that 365(89.2%), 200(48.9%) and 196(47.9%) of the study participants have good knowledge, good practice and good attitude about menstrual hygiene respectively. Being grade 10 students [AOR=3.96, 95% CI =2.0-7.8], and having good practice of menstrual hygiene (AOR=2.52, 95% CI= 1.26-5) had positive association with menstrual hygiene knowledge. Maternal education level (AOR=1.86, 95% CI=1.18-2.9), being grade 10 students (AOR =2.3, 95% CI=1.48-3.56) were associated factors for practicing menstrual hygiene. Being grade 10 students (AOR=1.9, 95% CI=1.2-2.8), age ≥18 years (AOR=1.67, 95% CI=1.09-2.55) were statistically and positively associated with the attitude of menstrual hygiene.
Bacterial isolates and their antimicrobial susceptibility pattern among patients with ocular infections at the University of Gondar Hospital, Northwest Ethiopia: A 10-years retrospective study
Authors: Seifu Daniel , Tesfaye Amanuel , Yiheyis Zufan , Mohammed Mekin , Belay Gizeaddis , Eshete Setegn , Belachew Teshome 
Published: August 2019

Abstract
Abstract

Objective: The aim of this study was to identify potential bacterial isolates and their antimicrobial susceptibility pattern among patients who visited eye clinic of Gondar university hospital.

Results: From year of January 2009 to January 2019 a total of 319 eye discharge specimens were submitted for microbiological analysis, of which 133(41.7%) were culture positive. A total of 42(31.6%) Gram negatives and 91(68.4%) Gram-positive bacteria were isolated. Among isolated Gram-negative bacterial species, Klebsiella spp was the most predominant, 42.9% followed by E. coli 26.2%. Among isolated Gram-positive pathogenic bacterial species, S. aureus was the most prevalent, 59.5% followed by S. pyogenes , 8% and S. pneumoniae , 5.5%. Most of the bacterial isolates were resistant to cotrimoxazole, 81.6%, amoxicillin, 78.7%, tetracycline,76.2%, and ampicillin 75.9%. About 47.4 % of bacterial isolates showed multi drug resistance to three or more classes of antimicrobials. Antimicrobials like: ampicillin, amoxicillin, ceftriaxone, ciprofloxacin, and norfloxacin exhibited year to year increment of resistance (p<0.0001).
A defined grey zone with in fetal growth curves for predicting adverse neonatal morbidity in fetuses being small for their gestational age at term in uncomplicated pregnancies
Authors: Sahin Mefkure Eraslan , Madendag Ilknur Col , Sahin Erdem , Madendag Yusuf , Ozdemir Fatma , Tayyar Ahter Tanay , Acmaz Gokhan , Muderris Iptisam Ipek 
Published: August 2019

Abstract
Background: “Small for gestational age” (SGA) is a term used to define an important risk factor for both neonatal morbidity and mortality. Our hypothesis suggests that adverse neonatal morbidity (ANM) in fetuses can occur when the birth weight is closer to 10th percentile. For example, although a fetus with a birth weight within the 11th or 12th percentile is appropriate for gestational age (AGA), it is difficult to clearly distinguish these fetuses from SGA fetuses for ANM; therefore we suggest defining a transition zone, or “grey zone”, for ANM. The aim of the present study was to examine ANM frequency in fetuses using this newly defined grey-zone percentile.
Methods: This retrospective analysis comprised 7,817 pregnant women with uncomplicated pregnancies and single deliveries between 37 0/7 and 41 6/7 gestational weeks. The babies were divided into groups according to birth weight percentiles as follows: (1) SGA, (2) 10–20 percentile, and 21–90 percentile. The primary outcome was ANM, defined as any of the following: Apgar score <4 at 5 min; respiratory distress; mechanical ventilation; intraventricular hemorrhage, grade III or IV; necrotizing enterocolitis, stage 2 or 3; neonatal sepsis, stillbirth or neonatal death.
Results: Demographic and obstetric characteristics of the mothers were similar among the groups. ANM rates were 10.7% in the SGA group, 6.8% in the 10–20 percentile group, and 2.1% in the 21–90 percentile group, a significant difference. ANM was 5-fold higher in the SGA group and 3.2-fold higher in the 10–20 percentile group than in the 21–90 percentile group. Delivery induction or augmentation, cesarean delivery for non-reassuring fetal heart rate or fetal distress, apgar score <4 at 5 min, mechanical ventilation, neonatal sepsis, stillbirth, or neonatal death significantly increased in the 10–20 percentile group compared with those in the 21–90 percentile group.
Conclusion: In uncomplicated pregnancies, ANM for SGA fetuses born at term are significantly worse than that for AGA fetuses. Fetuses with a birth weight within the 10–20 percentile (grey zone) had a significant increased risk of ANM than those within the 21–90 percentile.
Factors associated with smartphone addiction risk in preschool children
Authors: Park Jeong Hye 
Published: August 2019

Abstract
Background

This study aimed to identify the factors associated with smartphone addiction risk among preschool children. Thus far, little is known about these factors in younger children compared to older children or adolescents, although the age at first use of a smartphone is decreasing.

Methods

A cross-sectional study design was used. Data were obtained from the nationwide survey on smartphone overdependence conducted in 2017 in South Korea by the Ministry of Science and ICT and the National Information Society Agency. Data from 1,378 preschool children were analysed using binominal logistic regression analysis. This study complied with the Strengthening the Reporting of Observational Studies in Epidemiology.

Results

Of the samples, 17.1% showed a risk of smartphone addiction. The odds of high risk for smartphone addiction increased with the duration of smartphone use during the week and the frequency of smartphone use over the weekend. Using smartphones to watch TV shows and videos significantly increased the odds of smartphone addiction risk, whereas using smartphones for education and games did not.

Conclusions

The findings of the present study showed that, similar to children in other age groups, preschool children were also exposed to the risk of smartphone addiction. To reduce smartphone addiction risk in these children, parents should be aware of their risk of smartphone addiction and consider allowing their children less than 30 minutes of smartphone use during the week and more opportunities for physical activities especially over the weekend. Our findings also suggested that parent-centred education needs to be provided to correct parents’ perceptions. Information on smartphone addiction should be provided to parents along with an explanation that children’s smartphone use for educational purposes is beneficial; however, its use for the parents’ convenience or other purposes was not.
Giving women WOICE postpartum: prevalence of maternal morbidity using the WHO-WOICE instrument
Authors: MN Lamus , Lozano Stephanie , CM Charles , JP Guida , MA Parpinelli , Cecatti JG , Vidarte MF , Lale Say , Chou D , Costa Maria Laura 
Published: August 2019

Abstract
Background

There are no accurate estimates of the prevalence of non-severe maternal morbidities. Given the lack of instruments to fully assess these morbidities, the World Health Organization (WHO) developed an instrument called WOICE.

Objective

To evaluate the prevalence of non-severe maternal morbidities in puerperal women and analyses factors associated to impaired clinical, social and mental health conditions.

Method

A cross-sectional study with 519 postpartum women in a single encounter 6 to 12 weeks postpartum. The WOICE questionnaire included three sections: the first with maternal and obstetric history, sociodemographic data, risk and environment factors, violence and sexual health; The second considers functionality and disability, general symptoms and mental health; and the third includes data on physical and laboratory tests. Data collection was supported by Tablets with REDCAP software. Initially, a descriptive analysis was performed, with general prevalence of all variables contained in the WOICE, including scales on anxiety and depression (GAD-7 and PHQ-9- altered if ≥10), functionality (WHODAS- altered when ≥37.4) and data on violence and substance use. Subsequently, an evaluation of cases with alterations was performed, with a logistic regression to investigate factors associated to impaired non-clinical and clinical conditions.

Results

517 women were included, majority (54.3%) multiparous, ages between 20 and 34 years (65.4%) and with partner (75,6%). Over a quarter had (26.2%) preterm birth, however good perinatal outcomes. Around a third (30.2%) reported health problems informed by the physician, although more than 80% considered having good or very good health. About 10% reported any substance and 5.9% suffered violence. Anxiety was identified in 19.8% of cases, depression in 36.9% and altered functioning in 4.4% of women. Logistic regression identified that poor overall health rating was associated to increased anxiety/depression and impaired functioning. Having a partner reduces the perception of women on the presence of clinical morbidities.

Conclusion

During postpartum care, women presented high frequency of anxiety and depression and relevant frequency of substance use and violence. These aspects of women´s health need further evaluation and specific interventions to improve quality of care.
La primera infancia, un compromiso social
Authors: Suspes María Mercedes 
Published: August 2019

Es el niño el ser más indefenso de la sociedad al cual los padres, maestros, adultos y gobiernos tienen la obligación de dar lo mejor. De acuerdo con lo anterior el Estado junto con diversas ONG han elaborado distintos programas, políticas y estrategias para fomentar el crecimiento integral de la población infantil, especialmente la que comprende entre los cero a los cinco años de edad.
La infancia es catalogada como la etapa base del ser humano, en la que se establece el desarrollo de habilidades neuronales y motrices. Por eso es vital que el niño crezca en un entorno en donde el juego y el diálogo sean medios primordiales para su estimulación diaria.
La estimulación temprana, se inicia desde el momento de la gestación del naciturus, etapa en la cual la madre gestante debe proporcionarle a su hijo alimento y un ambiente favorable y tranquilo, ya que todo lo que vive la madre es percibido por el feto, siendo los periodos dela gestación y la niñez parte fundamental de la vida de cada persona.
Khuruj and Family Economic Resilience: Study on Jama’ah Tabligh Family in Medan City
Authors: Nurhayati Nurhayati 
Published: August 2019

<em>Khuruj</em> for preach by leaving the family is a must for every member of Jama’ah Tabligh (JT). When <em>khuruj</em> time, JT members cannot conduct their duty as head of the interested household especially to fulfill family economic needs. It is often, they <em>khuruj</em> without leaving enough provision of needs for their family. It is understandable why JT members are often accused as a group that neglects their family not even caring for the family. This research objective is to analyze survival strategy and tactics of the JT family by using a qualitative method. The researcher will conduct an in-depth interview with JT members and their family. Through this field research is found that 1) JT family has a strong belief that their sustenance is the gift of God. 2) Provision of needs that is left by the husband is enough to be utilized as long as being managed with sincerity. 3) JT family has a special survival strategy. So, <em>khuruj</em> is a method of da’wah that does not disturb family economic resilience.
Influence of air bubble flow structure on the rate of water purification by the bubble-film extraction method
Authors: Gevod V. S. , Borisov I. A. 
Published: August 2019

Abstract
Bubble-film extraction (upgraded bubble flotation) is one of the modern methods for purifying contaminated water from surface-active impurities. The features of this method have been considered from the standpoints of the equilibrium and dynamics of surfactant accumulation on floated air bubbles with different sizes. Within a certain ratio of dimension and quantity of air bubbles in their stream transferring adsorbed surfactants from the water bulk into the bubble-film extractor, the productivity of the process increases many times. The effect is ensured by a collective fusion of big and small air bubbles in their close-packed state (embedded system) inside the bubble-film extractor. The driving forces are impulses of capillary waves initiated at the bursting of big air bubbles as constituent ‘destructive’ units of that system.
Detecting urban water consumption patterns: a time-series clustering approach
Authors: Leitão Joaquim , Simões Nuno , Sá Marques José Alfeu , Gil Paulo , Ribeiro Bernardete , Cardoso Alberto 
Published: August 2019

Abstract
The need for efficient management of water distribution systems is a growing concern for economic, environmental and social reasons. Water supply systems are commonly designed to ensure adequate behaviour under the worst conditions, such as maximum consumption, which leads to overestimation in supply tanks and energy waste. While overestimation should be considered, to account for unpredictable demands and emergency scenarios, we advocate that a detailed understanding of consumption patterns enables an improvement in water management and is additionally beneficial to correlated resources such as electricity. A novel framework to detect water consumption patterns is developed and applied to an urban scenario. Observed discrepancies among computed patterns enable readjustments of supplied water flowrate, thus promoting effective water allocation and pumping costs, while mitigating water contamination risks.