bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial Report of Second-Line FOLFIRI in Combination with Ramucirumab in Advanced Gastroesophageal Adenocarcinomas: A Multi-Institutional Retrospective Analysis
Authors: Klempner Samuel J. , Maron Steven B. , Chase Leah , Lomnicki Samantha , Wainberg Zev A. , Catenacci Daniel V.T. 
Published: November 2018

Abstract

Background
The randomized phase III RAINBOW trial established paclitaxel (pac) plus ramucirumab (ram) as a global standard for second-line (2L) therapy in advanced gastric and gastroesophageal junction adenocarcinoma, together gastroesophageal adenocarcinoma (GEA). Patients (pts) receiving first-line (1L) FOLFOX often develop neuropathy that renders continued neurotoxic agents in the 2L setting unappealing and other regimens more desirable. As such, FOLFIRI-ram has become an option for patients with 2L GEA. FOLFIRI-ramucirumab (ram) has demonstrated safety and activity in 2L colorectal cancer, but efficacy/safety data in GEA are lacking.

Subjects, Materials, and Methods
Patients with GEA treated with 2L FOLFIRI-ram between August 2014 and April 2018 were identified. Clinicopathologic data including oxaliplatin neurotoxicity rates/grades (G), 2L treatment response, progression-free survival (PFS), overall survival (OS), safety, and molecular features were abstracted from three U.S. academic institutions. Kaplan-Meier survival analysis was used to generate PFS/OS; the likelihood ratio test was used to determine statistical significance.

Results
We identified 29 pts who received 2L FOLFIRI-ram. All pts received 1L platinum + fluoropyrimidine, and 23 of 29 (79%) had post-1L neuropathy; 12 (41%) had G1, and 11 (38%) had G2. Patients were evenly split between esophagus/gastroesophageal junction (12; 41%) and gastric cancer (17; 59%). Among evaluable pts (26/29), the overall response rate was 23% (all partial response) with a disease control rate of 79%. Median PFS was 6.0 months and median OS was 13.4 months among all evaluable pts. Six- and 12-month OS were 90% (n = 18/20) and 41% (n = 7/17). There were no new safety signals.

Conclusion
We provide the first data suggesting FOLFIRI-ram is a safe, non-neurotoxic regimen comparing favorably with the combination of pac + ram used in the seminal RAINBOW trial.

Implications for Practice
Results of this study provide initial support for the safety and efficacy of second-line (2L) FOLFIRI-ramucirumab (ram) after progression on first-line platinum/fluoropyrimidine in patients with gastroesophageal adenocarcinoma (GEA). The overall response, progression-free survival, overall survival, and toxicity profile compare favorably with paclitaxel (pac) + ram and highlight the importance of the ongoing phase II RAMIRIS trial examining FOLFIRI-ram versus pac + ram in 2L GEA (NCT03081143). FOLFIRI-ram may warrant consideration for inclusion as an alternate regimen in consensus guidelines for GEA.
Лицензия на независимую мобильность школьников
Authors: Глазков Константин Павлович 
Published: November 2018

Независимая мобильность считается важным фактором в развитии детей. В настоящей статье на данных опроса школьников (N = 568) рассматривается вопрос формирования разрешительных и запретительных установок на независимую мобильность в зависимости от форматов родительского сопровождения и самостоятельного посещения мест детьми. Была выявлена двойственная связь между тем, с кем бывают школьники разных возрастных групп (8–12, 13–17 лет) в самых удаленных от дома и самых посещаемых местах, и расстоянием до этих мест. Если школьники посещают места неподалеку от дома одни,то расстояние от дома до самых удаленных мест у них больше, чем у школьников, которые самостоятельно перемещаются вдали от дома. Однако если школьники бывают одни в самых удаленных местах,то часто посещаемые места находятся дальше от дома. Выявленная взаимосвязь описывается механизмами ближнего и дальнего радиуса родительского контроля, когда совместное с родителями посещение («ближний радиус») удаленных мест способствует увеличению доверия со стороны родителя к независимой мобильности школьника и, как следствие, расстояний посещаемых мест от дома, в то время как самостоятельное посещение («дальний радиус») близлежащих мест также увеличивает расстояние самых удаленных мест, но уже не на основании родительской опеки, а на основании успешного опыта мобильности самого ребенка1, 2.
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1 Статья подготовлена по данным Центра исследований современного детства НИУ ВШЭ.
2 Автор выражает признательность Центру исследований современного детства НИУ ВШЭ и, в частности, Елизавете Сивак за поддержку, комментарии и критику в процессе подготовки данной статьи.
Bevándorláspolitika és többszintű kormányzás: osztrák tapasztalatok
Authors: Hardi Tamás , Patay Tünde 
Published: November 2018

A nemzetközi vándorlási folyamatok nemzeti és regionális szinten is formálják a gazdasági teljesítményt, a munkaerőpiac jellegét, a társadalom szerkezetét és igényeit. A bevándorlás pozitív hatással lehet a versenyképességre, azonban fiskális, társadalmi és strukturális feladatokkal is számolni kell. Jellemzően a jövedelemkülönbségek és a munkaerőpiaci diszkrimináció, a térbeli és a társadalmi szegregáció, illetve a jóléti ellátás területén jelentkező kihívásokra kell megoldást találnia a politikának.
Ausztriába az utóbbi évtizedekben évente átlagosan 120 ezer új bevándorló érkezett – a mostani menekültügyi hullámtól eltekintve. Ma több mint másfél millió migrációs háttérrel rendelkező személy él az ország területén, túlnyomó részük első generációs bevándorló. Az osztrák tartományok, illetve az egyes települések maguk is felismerték a bevándorláshoz kapcsolódó törekvések és intézkedések jelentőségét. A nemzetközi vándorlási folyamatok vizsgálata mégis túlnyomórészt nemzeti szinten történik, illetve egy-egy nagyvárosra, településre fókuszál.
A tanulmány a jogszabályok és migrációpolitikai dokumentumok összevetése alapján elemzi Ausztria és tartományainak bevándorláspolitikai lehetőségeit, célkitűzéseit, prioritásait. Rámutat a többszintű, integrált kormányzás sajátosságaira, kiemelve a főbb feladatköröket, valamint a főbb különbségeket.
Combination of pharmacological and non-pharmacological approaches in patients with hypertensive encephalopathy and hemorheological disorders
Authors: Pospelova M. L. , Sorokoumov V. A. , Alekseeva T. M. , Ivanova N. E. 
Published: November 2018

objective. To study the impact of complex treatment (acetylsalicylic acid, hirudotherapy, phytotherapy) on the functional activity of thrombocytes in patients with hypertensive encephalopathy. design and methods. An open prospective study included 25 patients with hypertensive encephalopathy and dysfunction of thrombocytes activity. All patients took acetylsalicylic acid. A simultaneous course of hirudotherapy (10 sessions, 2,5 months; own patent of the Russian Federation № 2327494) and a course of phytotherapy (polycomponent infusion, for 2,5 months; own patent of the Russian Federation № 2542423) were conducted. Functional activity of thrombocytes was studied by the phase contrast microscope at baseline and after the treatment was completed. Results. Initially, 25 patients with hypertensive encephalopathy showed abnormal platelet functional activity in the presence of acetylsalicylic acid: a decrease in the number of intact platelets — discocytes in 9 patients; increased number of activated cells with discoquinocyte sprouts on the surface — in 18 people; active forms in 17 patients; platelet aggregates — in 15 patients; increased number of small aggregates per 100 free thrombocytes — 13 patients; large aggregates — in 2 patients. After hirudotherapy and herbal medicine were applied in addition to acetylsalicylic acid, complete normalization of platelet functional activity was achieved in 11 of 25 patients, and partial normalization — in 12 subjects. conclusions. The complex approach, including both drug treatment (acetylsalicylic acid) and the course of hirudotherapy and phytotherapy showed a positive impact on the intravascular platelet activity in patients with hypertensive encephalopathy and initial disturbances of the platelet functional activity. As a result, the number of intact forms of platelets increased, the number of early and late active forms (discoquinocytes, spheroechinocytes and bipolar cells) decreased. Also the number of platelet aggregates and small aggregates reduced. Such a multimodal approach can be implemented in aspirin resistance, a high risk of primary and recurrent vascular events. The method is safe and well tolerated by patients.
Pengaruh Pemberian Jus Tomat (Solanum lycopersicum) terhadap Jumlah Sel Radang di Alveolus Tikus Wistar (Rattus norvegicus) yang Dipapar Asap Rokok Kretek Subkronik
Authors: Mustika Dewi , Subandi Subandi 
Published: November 2018

<p class="Abstract">Asap rokok mengandung radikal bebas yang dapat menyebabkan proses inflamasi pada saluran nafas. Peningkatan jumlah sel radang pada alveolus paru dapat semakin meningkatkan kondisi stres oksidatif dikarenakan sel radang juga memicu timbulnya radikal bebas. Oleh karena itu, pemberian antioksidan diharapkan dapat mengurangi proses keradangan pada alveolus paru. Tujuan dari penelitian ini untuk membuktikan pengaruh pemberian jus tomat, yang mengandung likopen, betakaroten, dan vitamin c, terhadap penurunan jumlah sel radang alveolus tikus Wistar jantan yang dipapar asap rokok subkronik. Pemaparan asap rokok dilakukan selama 9 minggu menggunakan <em>smoking pump</em>, dilanjutkan dengan pemberian jus tomat dengan dosis 1,15; 2,3; dan 4,6 ml/tikus perhari selama 3 minggu. Setelah 12 minggu, jaringan paru setiap tikus diambil, kemudian dibuat sediaan histopatologi dengan pengecatan HE. Sediaan diamati menggunakan mikroskop pada 10 lapang pandang untuk dilakukan penghitungan jumlah sel radang (neutrofil, limfosit, makrofag) yang terdapat pada septa interalveolaris. Data dianalisis menggunakan <em>One-Way ANOVA </em>dilanjutkan uji <em>Post hoc Tukey</em>. Hasil penelitian menunjukkan bahwa pemberian jus tomat dapat menyebabkan penurunan jumlah sel radang di alveolus pada ketiga dosis yang diberikan (p=0,000). Hasil uji korelasi <em>Pearson</em> menunjukkan bahwa semakin tinggi dosis jus tomat (0; 1,15; 2,3; 4,6 ml/hari) maka akan semakin menurunkan jumlah sel radang di alveolus (r= -0,868; p=0,000). Dari penelitian ini dapat disimpulkan bahwa pemberian jus tomat setelah paparan asap rokok dapat menurunkan jumlah sel radang di alveolus.</p>
METODE SLOW SAND FILTER DAN PENGUKURAN MPN COLIFORM SEBAGAI UPAYA PENINGKATAN KUALITAS AIR SUNGAI DI PEKAPURAN RAYA BANJARMASIN
Authors: Herlina Sri 
Published: November 2018

<p>Sungai Pekapuran Raya Banjarmasin merupakan salah satu kawasan pinggiran sungai yang padat penduduk, saat musim kemarau kondisi sungai terlihat dangkal dipenuhi tumpukan sampah, berwarna kecoklatan dan keruh. Penelitian ini bertujuan untuk mengukur MPN <em>Coliform</em> air sungai Pekapuran Raya dan melakukan pembinaan pada kelompok ibu Antasan Segra tentang peningkatan kualitas air sungai menggunakan metode <em>slow sand filter</em> (SSF). Desain penelitian adalah observasional analitik dengan pendekatan <em>cross sectional</em>, melibatkan 38 responden secara <em>total sampling</em>. Teknik pengumpulan data dan analisis masalah dilakukan dengan pendekatan PRA (<em>Participation Rural Appraisal</em>). Bahan yang digunakan dalam pengolahan air menggunakan metode SSF seperti pasir, arang aktif, sabut kelapa (Ijuk) dan batu koral/kerikil serta busa penyangga yang tersedia cukup banyak disekitar rumah warga. Hasil pengukuran MPN <em>Coli</em><em>form</em><em> </em>pada air sungai Pekapuran Banjarmasin menunjukkan positif terdapat bakteri Coliform sebesar &gt; 240/100 ml sampel, sedangkan ambang baku mutu yang dipersyaratkan yaitu 100 sel/100 ml air.</p><p> Analisis kualitas air secara fisik menggunakan <em>slow sand filter </em>menunjukkan tingkat kekeruhan air sungai dari berwarna kecokelatan menjadi bening setelah penyaringan, model ini memudahkan masyarakat memanfaatkan air sungai menjadi air bersih karena lebih sederhana, murah, serta aman.</p>
FRUCTOSE ALTERS THE EXPRESSION OF TYPE B LEPTIN RECEPTOR IN HYPHOTALAMUS AND INTESTINUM OF Rattus Novergicus
Authors: Rachmawati Ermin , Kristanti Risma Aprinda , Susanti Nurlaili 
Published: November 2018

<p><strong>Background</strong>: Several epidemiological data’s reported significant correlation between fructose consumption and diabetes mellitus type 2 by inducing insulin resistance. Leptin resistance induced by fructose was proposed as one novel mechanism that induce insulin resistance but the exact mechanism remains unclear. We hypothesize that fructose diminish the type b leptin receptors in hypothalamus and intestine.</p><p><strong>Aim</strong>: This study was aimed to elucidate fructose effect on the expression of leptin receptor type b in hypothalamus and intestine of Rattus novergicus.</p><p><strong>Method</strong>: twenty eight rats were used and divided into 4 groups: Group 1 was control, group 2 was given fructose 10%, group 3 was given fructose 30% and group 4 was given fructose 55% for 2 months. At the end of treatment, the animal were sacrificed and then the hypothalamus and intestine were collected. The expression of type b leptin receptor were measured by immunohistochemistry technique with primary antibody from <em>Bioss antibodies type</em> <em>Leptin receptor polyclonal antibody bs-0109R using </em>Staining kit <em>Skytec Laboratories and DAB chromogen. </em>A positive expression can be seen as a brown colour in cell cytoplasm and counted in 100 cell. The expression then analysed using SPSS 18 with anova one way tes (p&lt;0,05) followed by post hoc test after the data showed normality and homogeneity using Saphiro wilk and Levene test (p&gt;0,05).</p><p><strong>Result</strong>: There was significant differences in type b leptin receptors found in hypothalamus between each group (p&lt;0.05). The significant differences also could be seen in the expression between control and group fructose 30 and 50% in intestinal cell (p&lt;0.05).</p><p><strong>Conclusion</strong>: the consumption of Fructose 55% for 2 months attenuates the expression of type b leptin receptors in hypothalamus and intestine of <em>R</em><em>at novergicus</em>.</p><p> </p>
Karbapenem dirençli enterobactericeae suşların immünokromatografik yöntem ile değerlendirilmesi
Authors: Yapıcı Oktay , YAPICI Hafize , SAYGILI PEKİNTÜRK Nilüfer , AKGÜNEŞ Alper , AKGÜL Senem , Ekinci Bora 
Published: November 2018

Amaç: Son yıllarda, Enterobacteriaceae türlerine karşı artan antimikrobiyal
direnç küresel bir sorun olmaya devam etmektedir. Bu çalışmada karbapenem
dirençli Enterobactericeae suşlarında
immünokromatografik yöntem ile OXA-48 benzeri, KPC ve NDM beta-laktamaz
karbepenemazlarının varlığının araştırılması amaçlanmıştır.

Gereç ve
Yöntem: 1 Haziran 2017 ile 31 Mayıs 2018 tarihleri
arasında mikrobiyoloji laboratuvarına çeşitli servislerden ve yoğun bakımdan
gönderilen 717 Enterobactericeae suşu
çalışma kapsamına alındı. Geleneksel yöntemler (koloni morfolojisi, gram boyama
vb.) ve otomatize VİTEK-2 sistemi ile tanısı konulan Enterobactericea suşları değerlendirildi. VİTEK-2 sistemi ile
antibiyogramı yapılan ve EUCAST önerilerine göre en az bir karbapenem grubu
antibiyotiğe dirençli tespit edilen izolatlarda, karbapenem direnç tipi
RESIST-3 O.K.N. K-SET (Coris BioConcept, Gembloux, Belgium) immünokromatografik
yöntemle değerlendirildi.

Bulgular:&nbsp;Değerlendirilmeye alınan Eschericia
coli (n=430) ve Klebsiella pneumoniae
(n=210), Klebsiella ozanea (n=4), Serratia marcescens (n=50), Serratia odorifa (n=3) arasında 35
karbapenem dirençli suş saptandı. Tespit edilen diğer türler (Salmonella, Enterobacter, Proteus, Citrobacter, Morganella, Yersinia)
arasında karbapenem direnci saptanmadı. Enterobactericeae
türleri arasında %4,8 (n=35) karbapenemlere direnç tespit edildi. Klebsiella pneumoniae suşları arasında
%13,3 (n=28), Eschericia coli suşları
arasında %0,9 (n=4) oranında karbapenem direnci tespit edildi. Klebsiella pneumoniae suşlarında (n=28)
immünkromatografik yöntemle en fazla OXA-48 benzeri (n=13; %48) enzim direnci
gözlendi. OXA -48 benzeri enzim pozitif saplanan bu 13 suşun 9’u (%69) kolistine
duyarlı bulundu.

Sonuç:&nbsp;İlerleyen yıllarda mikrobiyoloji alanında daha kısa sürede, daha
uygun maliyette, yüksek duyarlılık ve seçiciliğe ait bu tür pratik yöntemlerin
kullanım alanının artacağını düşünmekteyiz.
Identification Of Potentialantibiotics – Drugs interaction On Pneumonia Prescription
Authors: Farida Yeni , Soleqah Anisa Dewi 
Published: November 2018

<p>Pneumonia is lower respiratory tract infections, which is the leading cause of death in developing countries. Antibiotics are the primary therapy in cases of pneumonia due to bacteria. The use of antibiotics with other drugs allowing harmful effect. This study aimed to determine the significancy of antibiotics interaction and determine the phase of potential drug interaction could be happened.<strong></strong></p><p>Data were collected retrospectively by taking data on the patient's medical record. Samples were obtained by purposive sampling. Inclusion criteria were patients diagnosed pneumonia with comorbid and got antibiotic therapy.</p><p>The results showed that there were 12 types of drugs combinationthat could potentially cause drug interactions .Potential interactions with other drugs antibiotics based on the literature occurred in the absorption phase (12.82%), metabolism (35.9%), and excretion (51.28%).</p>
Uji Aktivitas Antioksidan Ektrak Ethanol Daun Family Solanum Menggunakan Metode Reduksi Radikal Bebas DPPH
Authors: Antarti Anif Nur , Lisnasari Renita 
Published: November 2018

Antioksidan adalah zat yang menghambat atau mencegah kerusakan sel akibat oksidasi radikal bebas. Buah yang berasal dari tanaman yang termasuk dalam Solanum Family memiliki potensi sebagai antioksidan, namun aktivitas antioksidan pada bagian daun tidak diketahui. Penelitian ini bertujuan untuk mengetahui keragaman aktivitas antioksidan pada daun Solanum Family yaitu daun ciplukan (<em>Physalisan gulata</em> L.), daun takokak (<em>Solanumtorvum</em> Swartz) dan daun tomat (<em>Solanum lycopersicum</em> L.). Parameter aktivitas antioksidan diukur dengan nilai IC<sub>50</sub>. Metode Penelitian ini menggunakan ekstrak etanol daun ciplukan, daun takokak dan daun tomat diekstraksi dengan etanol 70% dengan metode perkolasi. Pengujian aktivitas antioksidan dengan DPPH (1,1-Diphenyl-2-picrylhydrazyl). Identifikasi kandungan fitokimia dan uji aktivitas antioksidan secara kualitatif dengan kromatografi lapis tipis (KLT). Aktivitas antioksidan uji kuantitatif dengan spektrofotometri UV-Vis pada panjang gelombang 515 nm dengan perbandingan vitamin C. Hasil penelitian menunjukkan bahwa daun Solanum Family mengandung flavonoid, saponin, dan polifenol. Nilai IC<sub>50</sub> daun ciplukan adalah 59,73 ± 0,24 ppm (aktivitas antioksidan kuat) daun tomat 80,79 ± 0,27 ppm (aktivitas antioksidan kuat), daun takokak 107,42 ± 0,43 ppm (aktivitas antioksidan sedang), injeksi vitamin C sebagai kontrol positif meiliki nilai IC<sub>50</sub>2,89 ± 0,20 ppm (aktivitas antioksidan sangat kuat). Hasil penelitian menunjukkan bahwa ekstrak etanol dari daun Solanum Family menghasilkan aktivitas antioksidan. Penelitian farmakologi lebih lanjut dilakukan untuk mengevaluasi aktivitas antioksidan daun Solanum Family.<p> </p>
A ST X-NUCLEO-BASED TELEMETRY UNIT FOR DETECTION AND WiFi TRANSMISSION OF COMPETITION CAR SENSORS DATA: FIRMWARE DEVELOPMENT, SENSORS TESTING AND REAL-TIME DATA ANALYSIS
Authors: Visconti P. , Sbarro B. , Primiceri P. 
Published: November 2018

Abstract
Telemetry is a technology that allows remote measurement and transmission of moving car information, allowing to collect a huge amount of data that are interpreted to ensure that car is performing at its optimum. In this research work, by using electronic modules and sensors available at very low costs, a reliable and accurate telemetry system was realized in order to monitor physical and mechanical parameters of a racing vehicle during its motion. Implemented data acquisition and wireless communication unit allows to collect, on board of vehicle, the temperature of engine compartment and cooling liquid, suspensions’ extensions, vehicle speed and also its orientation and acceleration and to send wirelessly all these data to a base station, where are monitored by technical staff, so ensuring quick intervention in case of malfunctioning. STM32 Nucleo development board, heart of realized telemetry system, properly programmed with the developed firmware, acquires data from used sensors and, through a WiFi radio module, sends them to the base station; the data are also stored on a SD memory card to avoid data losses. Sparkfun CAN module is employed for this aim and to interface the engine control unit with ST Nucleo board. Experimental tests were carried out for verifying correct operation of realized system; by analyzing trends over time of monitored vehicle parameters as function of the vehicle movements, driving conditions and race track, the technicians ensure safety of pilot life and also an optimization of the vehicle performances.
Dwipa Ontology III: Implementation of Ontology Method Enrichment on Tourism Domain
Authors: Kuntarto Guson Prasamuarso , Gunawan Irwan Prasetya , Moechtar Fahmi L. , Ahmadin Yudhiansyah , Santoso Berkah I. 
Published: November 2018

Abstract
This article summarizes some research results related to ontology enrichment specific to tourism domains from 2014 to 2017. Currently, some ontology enrichment approaches can use learning machinery such as support vector machine (SVM), Conditional Random Field (CRF) and kNN. Several studies have also been successful in evaluating ontology enrichment results with several parameters such as precision, recall and F-Measure. In addition, our research can enrich Dwipa Ontology II which has been successfully done by population to object / sample. The method used in this research is ontology enrichment method. This technique or method is used to show background knowledge (ontology) by adding new concepts and relationships through the extraction process. The enrichment process is done on semi-automated web document (corpus). The process using statistics and linguistics, by applying evaluation techniques by using reviewers in the field of tourism. The end result of Dwipa Ontology III (enriched ontology) contains 4 main classes, 15 subclasses and 199 samples / objects. The expansion of general concept / subclass knowledge under the attraction classes are: cultural parks, artists and monuments.
Scenario-based prediction of short-term river stage–discharge process using wavelet-EEMD-based relevance vector machine
Authors: Roushangar Kiyoumars , Alizadeh Farhad 
Published: November 2018

Abstract
In this study, daily river stage–discharge relationship was predicted using different modeling scenarios. Ensemble empirical mode decomposition (EEMD) algorithm and wavelet transform (WT) were used as hybrid pre-processing approach. In the WT-EEMD approach, first temporal features were decomposed using WT. Furthermore, the decomposed sub-series were further broken down into intrinsic mode functions via EEMD to obtain features with higher stationary properties. Mutual information was used to select dominant sub-series and determine efficient input dataset. Relevance vector machine (RVM) was applied to forecast river discharge. Three scenarios were developed to predict river stage–discharge process. First, a successive-station form of forecasting was proposed by incorporating geomorphological features into the modeling process. Subsequently, an integrated RVM (I-RVM) was trained based on the concept of the cascade of reservoirs and the meta-learning approach. The proposed I-RVM had the semi-distributed characteristics of the river discharge model. Finally, a multivariate RVM was trained to predict discharge for different points of the river. For this reason Westhope station's features were used as input to predict discharge at downstream of the river. Results were compared with rating curve and capability of proposed models were approved in prediction of short-term river stage–discharge.