bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-renal transplant urolithiasis in children: an increasingly diagnosed complication: a retrospective cohort study
Authors: Ma Sophia , Taher Amir , Zhu Benjamin , Durkan Anne Maria 
Published: June 2019

ObjectiveUrolithiasis in renal transplant (RTx) recipients is a potential cause of allograft loss if obstruction is untreated. It is not clear if paediatric transplant recipients are following the global trend for increased prevalence of urolithiasis over time.Design/Setting/PatientsA retrospective chart review was undertaken to evaluate the frequency, risk factors and characteristics of post-RTx urolithiasis over two decades (1995–2016), in a tertiary Australian paediatric hospital.ResultsStones were diagnosed in 8 of 142 (5.6%) recipients, 6 of whom were transplanted in the latter decade. All patients were male, with a median age 4.9 years and median weight 11.8 kg. Presentation was with haematuria (n=4), pain (n=2), dysuria (n=2), stone passage (n=1) and asymptomatic (n=1). Time to presentation was bimodal; three stones were identified in the initial 3 months post RTx and the remainder after 31–53 months. Two stones were in association with retained suture material and two patients had recurrent urinary tract infections. The average stone size was 8.4 mm. Five stones were analysed; all contained calcium oxalate, three were mixed, including one with uric acid. Five (83.3%) children had hypercalciuria but none had hypercalcaemia. Cystolithotripsy was the the most common treatment (n=5), in combination with citrate supplementation. No graft was lost due to stones.ConclusionsCalculi occur with increasing frequency after renal transplantation. Clinicians need a high index of suspicion as symptoms may be atypical in this population. The cause for the increased frequency of stones in transplant recipients is not clear but is in keeping with the increase seen in the general paediatric population.
Observational cross-sectional study on Symptoms Associated to Moisture DAmage at Workplace: the SAMDAW study protocol
Authors: Nynäs Pia , Vilpas Sarkku , Kankare Elina , Karjalainen Jussi , Lehtimäki Lauri , Numminen Jura , Tikkakoski Antti , Kleemola Leenamaija , Uitti Jukka 
Published: June 2019

IntroductionMoisture damage (MD) exposure at work has been shown to increase the risk of new onset asthma and exacerbation of asthma. However, most of the studies in this field have been questionnaire studies. A small proportion of MD-exposed workers are diagnosed with asthma. Many patients with MD exposure at work referred to secondary healthcare report intermittent hoarseness, loss of voice or difficulty to inhale, referring to functional or organic problems of the larynx. For accurate treatment, proper differential diagnostics is paramount. We present an ongoing observational study in which we describe the prevalence of respiratory, voice and other symptoms related to MD at work in patients referred to secondary healthcare. Case-control setting will be used to evaluate the frequencies of the background factors, bronchial hyperreactivity and laryngeal findings.Methods and analysisThe study sample consists of patients with workplace MD exposure and associated respiratory tract and/or voice symptoms referred to Tampere University Hospital. The clinical tests conducted to the study patients included comprehensive lung function tests, laboratory and skin prick tests, imaging and clinical evaluation by specialists of respiratory medicine, oto-rhino-laryngology and phoniatrics. The exposure assessment was performed by an occupational physician. The study patients filled out a questionnaire on previous illnesses and other background factors, which for comparison was also sent to 1500 Finnish-speaking people in the same hospital district randomly selected by the Finnish Population Information System. To explore how common laryngeal disorders and voice symptoms are in general, a part of the tests will be conducted to 50 asymptomatic volunteers.Ethics and disseminationThe regional ethics committee of Tampere University Hospital approved the study. All study subjects gave their written informed consent, which is required also from the controls. The results will be communicated locally and internationally as conference papers and journal articles.
Barriers to accessing cancer services for adults with physical disabilities in England and Wales: an interview-based study
Authors: Sakellariou Dikaios , Anstey Sally , Gaze Sarah , Girt Eleri , Kelly Daniel , Moore Barbara , Polack Sarah , Pratt Roger , Tyrer Gill , Warren Narelle , Wilkinson Wendy , Courtenay Molly 
Published: June 2019

ObjectivesThe aim of this study was to explore the barriers to accessing cancer services faced by adults with pre-existing physical disabilities.DesignCross-sectional, exploratory qualitative study. Data were collected by semistructured interviews and analysed thematically.SettingParticipants were recruited through statutory and third sector organisations in England and Wales between October 2017 and October 2018.Participants18 people with a diagnosis of cancer and a pre-existing physical disability.ResultsThe findings illustrate that people with physical disabilities in England and Wales face a variety of barriers to accessing cancer services. The overall theme that emerged was that participants experienced a lack of attitudinal and institutional preparation both from healthcare professionals and healthcare facilities. This overall theme is illustrated through three subthemes: lack of acknowledgment of disability, unseeing disability and physical inaccessibility.ConclusionsAs the population ages and increasing numbers of people live with cancer and disability, it is important to develop knowledge to respond to the needs of this population. The mere existence of services does not guarantee their usability. Services need to be relevant, flexible, and accessible and offered in a respectful manner. It is important that healthcare professionals work towards inclusive healthcare provision, enabling the utilisation of services by all. Necessary steps to be taken include better communication between the various professionals and across the different teams involved in patients’ care, raising awareness of how physical disability can affect or interact with cancer-related treatment and creating more accessible physical environments.
Views of prison staff in Scotland on the potential benefits and risks of e-cigarettes in smoke-free prisons: a qualitative focus group study
Authors: Brown Ashley , Sweeting Helen , Semple Sean , Bauld Linda , Demou Evangelia , Logan Greig , Hunt Kate 
Published: June 2019

ObjectiveElectronic cigarettes (e-cigarettes) were introduced into all Scottish prisons in February 2018, some months after prisons began preparing in 2017 for a smoking ban implemented in November 2018. In 2016/2017, prison staff views on the potential benefits and risks of e-cigarettes were explored in advance of the introduction of: (1) a smoking ban and (2) e-cigarettes.SettingFourteen prisons in Scotland.ParticipantsSeventeen focus groups and two paired interviews were conducted with 132 staff in 14 Scottish prisons 4–9 months before plans for a smoking ban were announced in July 2017. Both smoking and non-smoking staff were invited to participate.ResultsPrison staff highlighted three potential risks of e-cigarettes in smoke-free prisons: staff health risks from e-cigarette vapour; prisoner health risks from vaping; and risks to both groups from e-cigarette misuse, defects or accidents. Conversely, potential benefits of e-cigarettes in smoke-free prisons centred on: reducing smoking-related health harms to staff and prisoners; helping prisoners to manage without tobacco; and supporting staff to maintain safety and discipline in prison. Staff who participated in focus groups had limited experience of vaping and expressed some uncertainty and misunderstandings about e-cigarettes.ConclusionOur findings highlight that scientific uncertainty, misunderstanding about vaping, the complexity of prisons as workplaces and prison tobacco control policy all have implications for staff perceptions of the potential place of e-cigarettes in smoke-free prisons. To alleviate staff concerns, there is a need for reliable information on e-cigarettes. Staff may also require reassurances on whether products are ‘tamper proof’, and rules about vaping indoors.
Cohort profile: l’Actuel Pre-Exposure Prophylaxis (PrEP) Cohort study in Montreal, Canada
Authors: Greenwald Zoë R , Maheu-Giroux Mathieu , Szabo Jason , Robin Judith Alexia B , Boissonnault Michel , Nguyen Vinh-Kim , Thomas Réjean 
Published: June 2019

PurposeThel’Actuel PrEP Cohortwas established to monitor the uptake, effectiveness, safety and changes in sexual risk behaviours among individuals receiving pre-exposure prophylaxis (PrEP) for the prevention of HIV. This prospective dynamic cohort is based at Clinique médicale l’Actuel, a large sexual health clinic located in Montreal, Canada.ParticipantsSince the cohort inception in January of 2013 through June 2018, 2156 individuals consulted for PrEP as participants in the l’Actuel PrEP Cohort. Median age was 35 years (IQR: 29–44 years) and the majority (96%) were men who have sex with men. Among 1551 individuals who initiated PrEP care, the median duration of follow-up was 9.2 months (IQR: 3.7–19.6), with substantial variation based on year of cohort entry. Thel’Actuel PrEP Cohortcontains both daily and intermittent ‘on-demand’ PrEP users and has the largest reported population of intermittent PrEP users (n=406) in North America.Findings to dateNo incident HIV infections have occurred among individuals using PrEP over 1637 person-years of follow-up. However, retention in PrEP care is essential as three individuals who discontinued PrEP subsequently acquired HIV, translating to an HIV incidence of 3.9 cases per 100 person-years (95% CI: 1.3 to 12.1). Among a sample of participants with 1 year of follow-up before and after PrEP initiation (n=109), a moderate increase in sexually transmitted infections was observed following PrEP start.Future plansThel’Actuel PrEP Cohortcontinues to grow with new participants starting PrEP monthly and extended follow-up for existing users. The cohort data will be used for ongoing monitoring of PrEP and for population-level modelling of the impact of PrEP on HIV incidence in Montreal.
CareTrack Aged: the appropriateness of care delivered to Australians living in residential aged care facilities: a study protocol
Authors: Hibbert Peter D , Wiles Louise K , Cameron Ian D , Kitson Alison , Reed Richard L , Georgiou Andrew , Gray Len , Westbrook Johanna , Augustsson Hanna , Molloy Charlotte J , Arnolda Gaston , Ting Hsuen P , Mitchell Rebecca , Rapport Frances , Gordon Susan J , Runciman William B , Braithwaite Jeffrey 
Published: June 2019

IntroductionThe aged population is increasing rapidly across the world and this is expected to continue. People living in residential aged care facilities (RACFs) represent amongst the sickest and frailest cohort of the aged population, with a high prevalence of chronic conditions and complex comorbidities. Given the vulnerability of RACF residents and the demands on the system, there is a need to determine the extent that care is delivered in line with best practice (‘appropriate care’) in RACFs. There is also a recognition that systems should provide care that optimises quality of life (QoL), which includes support for physical and psychological well-being, independence, social relationships, personal beliefs and a caring external environment. The aims ofCareTrack Agedare to develop sets of indicators for appropriate care and processes of care for commonly managed conditions, and then assess the appropriateness of care delivered and QoL of residents in RACFs in Australia.Methods and analysisWe will extract recommendations from clinical practice guidelines and, using expert review, convert these into sets of indicators for 15 common conditions and processes of care for people living in RACFs. We will recruit RACFs in three Australian states, and residents within these RACFs, using a stratified multistage sampling method. Experienced nurses, trained in theCareTrack Agedmethods (‘surveyors’), will review care records of recruited residents within a 1-month period in 2019 and 2020, and assess the care documented against the indicators of appropriate care. Surveyors will concurrently assess residents’ QoL using validated questionnaires.Ethics and disseminationThe study has been reviewed and approved by the Human Research Ethics Committee of Macquarie University (5201800386). The research findings will be published in international and national journals and disseminated through conferences and presentations to interested stakeholder groups, including consumers, national agencies, healthcare professionals, policymakers and researchers.
Stepped-wedge randomised trial to evaluate population health intervention designed to increase appropriate anticoagulation in patients with atrial fibrillation
Authors: Wang Shirley V , Rogers James R , Jin Yinzhu , DeiCicchi David , Dejene Sara , Connors Jean M , Bates David W , Glynn Robert J , Fischer Michael A 
Published: June 2019

BackgroundClinical guidelines recommend anticoagulation for patients with atrial fibrillation (AF) at high risk of stroke; however, studies report 40% of this population is not anticoagulated.ObjectiveTo evaluate a population health intervention to increase anticoagulation use in high-risk patients with AF.MethodsWe used machine learning algorithms to identify patients with AF from electronic health records at high risk of stroke (CHA2DS2-VASc risk score ≥2), and no anticoagulant prescriptions within 12 months. A clinical pharmacist in the anticoagulation service reviewed charts for algorithm-identified patients to assess appropriateness of initiating an anticoagulant. The pharmacist then contacted primary care providers of potentially undertreated patients and offered assistance with anticoagulation management. We used a stepped-wedge design, evaluating the proportion of potentially undertreated patients with AF started on anticoagulant therapy within 28 days for clinics randomised to intervention versus usual care.ResultsOf 1727 algorithm-identified high-risk patients with AF in clinics at the time of randomisation to intervention, 432 (25%) lacked evidence of anticoagulant prescriptions in the prior year. After pharmacist review, only 17% (75 of 432) of algorithm-identified patients were considered potentially undertreated at the time their clinic was randomised to intervention. Over a third (155 of 432) were excluded because they had a single prior AF episode (transient or provoked by serious illness); 36 (8%) had documented refusal of anticoagulation, the remainder had other reasons for exclusion. The intervention did not increase new anticoagulant prescriptions (intervention: 4.1% vs usual care: 4.0%, p=0.86).ConclusionsAlgorithms to identify underuse of anticoagulation among patients with AF in healthcare databases may not capture clinical subtleties or patient preferences and may overestimate the extent of undertreatment. Changing clinician behaviour remains challenging.
Group singing in bereavement: effects on mental health, self-efficacy, self-esteem and well-being
Authors: Fancourt Daisy , Finn Saoirse , Warran Katey , Wiseman Theresa 
Published: June 2019

ObjectivesBereavement is associated with negative affective, cognitive, behavioural and physiological responses. However, factors, such as coping, self-efficacy and self-esteem, can buffer negative effects of grief, and can be increased through mutual support interventions, such as shared leisure activities. This study used a non-randomised controlled design to explore the effects of group choir singing on mental health among people who have been bereaved due to cancer.MethodsA total of 58 adults bereaved in the last 5 years who had not started psychological therapy in the last 12 weeks or medication for anxiety or depression in the last month were recruited and elected to join a choir (n=29) or participate in the non-intervention control group (n=29). Joining a choir involved engaging in 90 min weekly singing and social sessions for 12 weeks with a post-intervention assessment at week 24. We used linear mixed effects models adjusted for demographics, health-related variables, musical engagement and time since bereavement to model changes over time between the two groups in symptoms of anxiety, depression, well-being, self-efficacy and self-esteem.ResultsParticipants who sang in a choir had more stable symptoms of depression and levels of well-being, as well as gradual improvements in their sense of self-efficacy and self-esteem over the 24 weeks. In contrast, those in the control group showed gradual increases in depressive symptoms, reductions in levels of well-being and self-esteem and no improvement in their self-efficacy. These results were independent of all covariates.ConclusionsWeekly group singing could be a promising mutual support intervention for people experiencing grief.Trial registration numberNCT02756780.
SMCHD1 mutation spectrum for facioscapulohumeral muscular dystrophy type 2 (FSHD2) and Bosma arhinia microphthalmia syndrome (BAMS) reveals disease-specific localisation of variants in the ATPase domain
Authors: Lemmers Richard J L F , van der Stoep Nienke , Vliet Patrick J van der , Moore Steven A , San Leon Granado David , Johnson Katherine , Topf Ana , Straub Volker , Evangelista Teresinha , Mozaffar Tahseen , Kimonis Virginia , Shaw Natalie D , Selvatici Rita , Ferlini Alessandra , Voermans Nicol , van Engelen Baziel , Sacconi Sabrina , Tawil Rabi , Lamers Meindert , van der Maarel Silvère M 
Published: June 2019

BackgroundVariants in the Structural Maintenance of Chromosomes flexible Hinge Domain-containing protein 1 (SMCHD1) can cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) and the unrelated Bosma arhinia microphthalmia syndrome (BAMS). In FSHD2, pathogenic variants are found anywhere in SMCHD1 while in BAMS, pathogenic variants are restricted to the extended ATPase domain. Irrespective of the phenotypic outcome, both FSHD2-associated and BAMS-associated SMCHD1 variants result in quantifiable local DNA hypomethylation. We compared FSHD2, BAMS and non-pathogenic SMCHD1 variants to derive genotype–phenotype relationships.MethodsExamination of SMCHD1 variants and methylation of the SMCHD1-sensitive FSHD locus DUX4 in 187 FSHD2 families, 41 patients with BAMS and in control individuals. Analysis of variants in a three-dimensional model of the ATPase domain of SMCHD1.ResultsDUX4 methylation analysis is essential to establish pathogenicity of SMCHD1 variants. Although the FSHD2 mutation spectrum includes all types of variants covering the entire SMCHD1 locus, missense variants are significantly enriched in the extended ATPase domain. Identification of recurrent variants suggests disease-specific residues for FSHD2 and in BAMS, consistent with a largely disease-specific localisation of variants in SMCHD1.ConclusionsThe localisation of missense variants within the ATPase domain of SMCHD1 may contribute to the differences in phenotypic outcome.
Influence of structural highs on Triassic deposition on the western Barents Shelf
Authors: Anell I. , Indrevær K. , Serck C. S. 
Published: June 2019

Abstract
While the Triassic is comparatively a tectonically quiescent period in the dynamic development of the Barents Shelf, the depositional infill was strongly influenced by structural elements and there is a marked difference between lower and middle Triassic sedimentation. Southwards-propagating uplift of north–south-orientated elements along the incipient North Atlantic margin, from the mid-Carboniferous to the Early Triassic, generated uplift, tilt and erosion of the Sørkapp–Hornsund and palaeo-Stappen highs, and the Ringsel and Selis ridges. Progressive onlap along the flanks with probably no deposition until the Ladinian, which is probably condensed/partly missing, characterized the ensuing sedimentation. Late Permian–Early Triassic uplift of the Selis Ridge was concurrent with uplift and erosion of the Capria Ridge. Both elements also experienced a phase of Anisian–Ladinian erosion. The Gardarbanken High underwent a later Early Triassic uplift and a complex, probably condensed, deposition associated with the infill of advancing deltaic systems. The Ladinian, and more dominantly the Carnian, saw even blanketing of large parts of the Barents Shelf, almost wholly unaffected by the structural elements. The most noticeable influence at the time is the thinning of the progradational system approaching the Svalbard Platform, which remained comparatively shallow, as witnessed by the lowered clinoform angle and rapid deposition.
Electrophysiological responses to lateral shifts are not consistent with opponent-channel processing of interaural level differences
Authors: Ozmeral Erol J. , Eddins David A. , Eddins Ann Clock 
Published: June 2019

Cortical encoding of auditory space relies on two major peripheral cues, interaural time difference (ITD) and interaural level difference (ILD) of the sounds arriving at a listener’s ears. In much of the precortical auditory pathway, ITD and ILD cues are processed independently, and it is assumed that cue integration is a higher order process. However, there remains debate on how ITDs and ILDs are encoded in the cortex and whether they share a common mechanism. The present study used electroencephalography (EEG) to measure evoked cortical potentials from narrowband noise stimuli with imposed binaural cue changes. Previous studies have similarly tested ITD shifts to demonstrate that neural populations broadly favor one spatial hemifield over the other, which is consistent with an opponent-channel model that computes the relative activity between broadly tuned neural populations. However, it is still a matter of debate whether the same coding scheme applies to ILDs and, if so, whether processing the two binaural cues is distributed across similar regions of the cortex. The results indicate that ITD and ILD cues have similar neural signatures with respect to the monotonic responses to shift magnitude; however, the direction of the shift did not elicit responses equally across cues. Specifically, ITD shifts evoked greater responses for outward than inward shifts, independently of the spatial hemifield of the shift, whereas ILD-shift responses were dependent on the hemifield in which the shift occurred. Active cortical structures showed only minor overlap between responses to cues, suggesting the two are not represented by the same pathway. NEW & NOTEWORTHY Interaural time differences (ITDs) and interaural level differences (ILDs) are critical to locating auditory sources in the horizontal plane. The higher order perceptual feature of auditory space is thought to be encoded together by these binaural differences, yet evidence of their integration in cortex remains elusive. Although present results show some common effects between the two cues, key differences were observed that are not consistent with an ITD-like opponent-channel process for ILD encoding.