bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laryngotracheal Reconstruction in Adults Aged 60 Years and Older
Authors: Rehman Saad C. , Xie Deborah X. , Bekeny James R. , Gelbard Alexander , Wootten Christopher T. 
Published: February 2019

ObjectiveThe primary aim of this study is to evaluate the safety, efficacy, and execution of major open laryngotracheal operations for patients in the advanced decades.Study DesignCase series with chart review.SettingMultidisciplinary clinic at a tertiary care academic hospital.Subjects and MethodsPatient characteristics, operative course, and postoperative outcomes were retrospectively recorded for all airway reconstruction operations performed between 1999 and 2016 on patients aged ≥60 years Long‐term success was defined as prosthesis‐free survival at last follow‐up. Descriptive statistics were performed.ResultsTwenty‐nine patients met inclusion criteria, and the median age was 71 years (interquartile range, 63‐74). Tracheal resection was the most common procedure (13 patients), followed by laryngotracheal reconstruction (7 patients). Fifteen patients began their operation with a tracheostomy, 6 of whom underwent decannulation prior to leaving the operating room. Three additional patients underwent decannulation at follow‐up appointments and were prosthesis‐free at most recent follow‐up. The mean time to decannulation among these patients was 3 months. Of the 14 patients beginning their procedure without a tracheostomy, only 2 required permanent airway prosthesis. The overall long‐term rate of prosthesis‐free survival was 72.4% (21 of 29 patients). Factors suggestive of long‐term success include lower McCaffrey grade and lack of pulmonary disease, hypertension, or diabetes, as well as decreased red blood cell distribution width on preoperative complete blood count.ConclusionThrough careful patient selection, preoperative workup, and meticulous postoperative care, airway reconstruction procedures in patients aged ≥60 years are reasonably successful. Of 29 patients, 21 (72.4%) were successfully breathing long‐term without airway prosthesis.
Effects of Preoperative Iodine Administration on Thyroidectomy for Hyperthyroidism: A Systematic Review and Meta‐analysis
Authors: Tsai Chung‐Hsin , Yang Po‐Sheng , Lee Jie‐Jen , Liu Tsang‐Pai , Kuo Chi‐Yu , Cheng Shih‐Ping 
Published: February 2019

ObjectiveThe current guidelines recommend that potassium iodide be given in the immediate preoperative period for patients with Graves’ disease who are undergoing thyroidectomy. Nonetheless, the evidence behind this recommendation is tenuous. The purpose of this study is to clarify the benefits of preoperative iodine administration from published comparative studies.Data SourcesWe searched PubMed, Embase, Cochrane, and CINAHL from 1980 to June 2018.Review MethodsStudies were included that compared preoperative iodine administration and no premedication before thyroidectomy. For the meta‐analysis, studies were pooled with the random‐effects model.ResultsA total of 510 patients were divided into the iodine (n = 223) and control (n = 287) groups from 9 selected studies. Preoperative iodine administration was significantly associated with decreased thyroid vascularity and intraoperative blood loss. Significant heterogeneity was present among studies. We found no significant difference in thyroid volume or operative time. Furthermore, the meta‐analysis showed no difference in the risk of postoperative complications, including vocal cord palsy, hypoparathyroidism/hypocalcemia, and hemorrhage or hematoma after thyroidectomy.ConclusionPreoperative iodine administration decreases thyroid vascularity and intraoperative blood loss. Nonetheless, it does not translate to more clinically meaningful differences in terms of operative time and postoperative complications.
Correlation between diaphragmatic sagittal rotation and pulmonary dysfunction in patients with ankylosing spondylitis accompanied by kyphosis
Authors: Liu Chao , Wu Bing , Guo Yue , Song Kai , Tang Xiangyu , Fu Jun , Zhang Xuesong , Zheng Guoquan , Wang Yan 
Published: February 2019

Objective This study was performed to investigate the correlation between pulmonary dysfunction patterns and diaphragmatic sagittal rotation in patients with ankylosing spondylitis accompanied by kyphosis. Methods Thirty patients (27 male, 3 female) with kyphotic deformity secondary to ankylosing spondylitis underwent pedicle subtraction osteotomy and were retrospectively reviewed. All patients had undergone preoperative computed tomography with three-dimensional reconstruction, full-length spine radiographs, and pulmonary function tests. The diaphragmatic angle in the median sagittal plane (DA), pulmonary function test results, and radiological parameters were studied. Results Correlation coefficients were used to present the correlation between the DA and pulmonary function and the global kyphosis (GK), respectively. The data analysis presented positive correlations between the DA value and vital capacity (VC), forced vital capacity (FVC), expiratory reserve volume (ERV), inspiratory reserve volume (IRV) and peak expiratory flow (PEF). There was likewise a negative correlation between DA value and the global kyphosis (GK). Additionally, there were further significantly statistical improvements for DA, ERV, IRV, FVC, and VC, PEF, postoperatively. Conclusions Except for the restriction of the chest wall motion and the abnormalities of lung parenchyma, the diaphragmatic sagittal rotation is also an influencing factor of pulmonary dysfunction in patients with ankylosing spondylitis accompanied by kyphosis.
Spherical silica nanoparticles promote malignant transformation of BEAS-2B cells by stromal cell-derived factor-1α (SDF-1α)
Authors: Guo Chong , You Ding-Yun , Li Huan , Tuo Xiao-Yu , Liu Zi-Jie 
Published: February 2019

Objective This study aimed to examine the role of spherical silica nanoparticles (SiNPs) on human bronchial epithelial (BEAS-2B) cells through inflammation. Methods Human mononuclear (THP-1) cells and BEAS-2B cells were co-cultured in transwell chambers and treated with 800 mmol/L benzo[ a]pyrene-7, 8-dihydrodiol-9, 10-epoxide (BPDE) and 12.5 µg/mL SiNPs for 24 hours. For controls, cells were treated with BPDE alone. Subcutaneous tumorigenicity and epithelial-mesenchymal transition (EMT) of BEAS-2B cells were measured. The cells were blocked with a stromal cell-derived factor-1α (SDF-1α)-specific antibody. EMT was analyzed in cells treated with 800 mmol/L BPDE and 12.5 µg/mL SiNPs relative to matched control cells and xenografts in vivo. Serum SDF-1α levels were measured in 23 patients with lung adenocarcinoma in Xuanwei, in 25 with lung adenocarcinoma outside Xuanwei, and in 22 with benign pulmonary lesions in Xuanwei. Results SiNPs significantly promoted tumorigenesis and EMT, induced the release of SDF-1α, and activated AKT (ser473) in BEAS-2B cells. EMT and phosphorylated AKT (ser473) and glycogen synthase kinase-3β levels were decreased when blocked by SDF-1α antibody in BEAS-2B cells. SDF-1α was mainly secreted by THP-1 cells. Conclusion SiNPs combined with BPDE promote EMT of BEAS-2B cells via the AKT pathway by inducing release of SDF-1α from THP-1 cells.
Effect of Pharmacy-Driven Bedside Discharge Medication Delivery Program on Day 30 Hospital Readmission
Authors: Lam Simon W. , Sokn Erick 
Published: February 2019

Background: Previous studies demonstrated that transitions of care bundles, which include bedside discharge medication delivery (BDMD), may be helpful in decreasing hospital readmissions. Objective: To evaluate the effects of BDMD alone on day 30 readmission rates. Methods: Retrospective, cohort study comparing those who received pharmacy-driven BDMD to usual discharge. Primary outcome was day 30 readmission rates. Multivariable logistic regression was used to account for baseline differences between groups. Results: A total of 30916 patients met inclusion and exclusion criteria. Of those, 2253 (7%) received BDMD and 28663 (93%) received usual care. Significant differences in age, distance from hospital, race, marital status, insurance type, previous hospitalizations, admission source, baseline comorbidities, and medication counts were observed between groups. Patients who received BDMD were less likely to have day 30 readmissions (10.6% vs 12.8%, P = .002). However, after adjusting for baseline characteristics, BDMD was not an independent predictor of day 30 readmission (adjusted odds ratio = 0.91, 95% confidence interval = 0.79-1.04, P = .17). BDMD was associated with decreased day 14 readmissions in an unadjusted analysis. Conclusions: BDMD was not independently associated with a reduction in day 30 readmissions. Future studies should focus on targeting patients who are most likely to benefit from this service.
Neuroinflammation and central PI3K/Akt/mTOR signal pathway contribute to bone cancer pain
Authors: Zhang Jian , Wang Luping , Wang Hushan , Su Zhenbo , Pang Xiaochuan 
Published: February 2019

Background Pain is one of the most common and distressing symptoms suffered by patients with progression of cancer; however, the mechanisms responsible for hyperalgesia are not well understood. Since the midbrain periaqueductal gray is an important component of the descending inhibitory pathway controlling on central pain transmission, in this study, we examined the role for pro-inflammatory cytokines of the periaqueductal gray in regulating mechanical and thermal hyperalgesia evoked by bone cancer via phosphatidylinositide 3-kinase (PI3K)–mammalian target of rapamycin (mTOR) signals. Methods Breast sarcocarcinoma Walker 256 cells were implanted into the tibia bone cavity of rats to induce mechanical and thermal hyperalgesia. Western blot analysis and ELISA were used to examine PI3K/protein kinase B (Akt)/mTOR and pro-inflammatory cytokine receptors and the levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α). Results Protein expression levels of p-PI3K/p-Akt/p-mTOR were amplified in the periaqueductal gray of bone cancer rats, and blocking PI3K–mTOR pathways in the periaqueductal gray attenuated hyperalgesia responses. In addition, IL-1β, IL-6, and TNF-α were elevated in the periaqueductal gray of bone cancer rats, and expression of their respective receptors (namely, IL-1R, IL-6R, and tumor necrosis factor receptor (TNFR) subtype TNFR1) was upregulated. Inhibition of IL-1R, IL-6R, and TNFR1 alleviated mechanical and thermal hyperalgesia in bone cancer rats, accompanied with downregulated PI3K–mTOR. Conclusions Our data suggest that upregulation of pro-inflammatory cytokine signal in the periaqueductal gray of cancer rats amplifies PI3K–mTOR signal in this brain region and alters the descending pathways in regulating pain transmission, and this thereby contributes to the development of bone cancer-induced pain.
Are we there yet with patent foramen ovale closure for secondary prevention in cryptogenic stroke? A systematic review and meta-analysis of randomized trials
Authors: Agasthi Pradyumna , Kolla Kantha Ratnam , Yerasi Charan , Tullah Sibghat , Pulivarthi Venkata Siva , Louka Boshra , Arsanjani Reza , Yang Eric H , Mookadam Farouk , Fortuin F David 
Published: February 2019

Background: We performed a meta-analysis to evaluate the benefit of patent foramen ovale closure in stroke prevention. Methods: We searched Medline/PubMed, EMBASE, Web of Science and Cochrane central database for randomized control trials assessing the incidence of recurrent stroke after patent foramen ovale closure when compared to medical therapy. Pooled odds ratio and 95% confidence intervals were calculated using a random effects model. The heterogeneity among studies was tested using the χ2 test and inconsistency was quantified using the I2 statistic. Results: Our search strategy yielded 71 articles. We included five studies with a total of 3440 patients. Median age in the device group was 45 (43, 5.5) years and in the medical group was 45 (44.5, 46) years; 52% were male, 27.7% of patients had an atrial septal aneurysm, 25% had hypertension, and 20.5% had diabetes mellitus. The median follow-up time was 44 (34.5–50) months. The pooled odds ratio of recurrent stroke, transient ischemic attack and composite end point of stroke + transient ischemic attack + peripheral embolism in the patent foramen ovale closure versus medical therapy group were 0.4 (95% confidence interval 0.25–0.63, I2 = 57.5%), 0.93 (95% confidence interval 0.61–1.42, I2 = 0%), and 0.6 (95% confidence interval 0.44–0.82, I2 = 0%), respectively. The incidence of atrial fibrillation was found to be significantly higher in the patent foramen ovale closure group with odds ratio of 6 (95% confidence interval 3.13–11.4, I2 = 33.5%). On subgroup analysis, patent foramen ovale closure appeared to benefit males and patients with a large shunt. Number needed to treat to prevent one recurrent stroke with patent foramen ovale closure is 42. Number needed to harm to cause one atrial fibrillation with patent foramen ovale closure is 39. Conclusion: This meta-analysis of randomized trials concludes that percutaneous patent foramen ovale closure is effective in recurrent stroke prevention especially in males and in those with a large shunt.
Evaluation of arthroscopic rotator cuff repair results in patients with anterior greater tubercle cysts
Authors: Şahan Mehmet Hamdi , Serbest Sancar , Tiftikçi Uğur , Durgut Erdogan , İnal Mikail 
Published: February 2019

Purpose: The purpose of this study was to investigate the clinical results of arthroscopic rotator cuff repair in patients with anterior greater tubercle cyst in magnetic resonance imaging (MRI). Methods: The cyst-present group comprised 38 patients with anterior greater tubercle cyst in MRI, and age- and sex-matched 30 patients without cyst in humeral head were included in the control group. The cystic group was divided into two groups, smaller than 5 mm (21 patients) and larger than 5 mm (17 patients), according to the cyst size. A total of three groups were created. In the evaluation of clinical outcomes, modified University of California at Los Angeles (UCLA) and the Western Ontario Rotator Cuff Index (WORC) were used. The visual analog scale (VAS) was used to assess pain. One-way analysis of variance was used to compare VAS, UCLA, and WORC scores among the groups. Results: There was a statistically significant difference in the clinical results of VAS, UCLA, and WORC among the cystic and noncystic groups in the anterior greater tubercle ( p < 0.05). There was also a statistically significant difference in the clinical results of UCLA, WORC, and VAS scores according to the cyst sizes in the anterior greater tubercle cyst group ( p < 0.05). Conclusion: Anterior greater tubercle cysts have negative effects on rotator cuff repair results. If the anterior greater tubercle cyst size is greater than 5 mm, the negative effects of rotator cuff repair results are more pronounced. An understanding of anterior greater tubercle cysts has a critical importance for rotator cuff surgery planning.
MYD88 L265P mutation and CDKN2A loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas
Authors: Nayyar Naema , White Michael D. , Gill Corey M. , Lastrapes Matthew , Bertalan Mia , Kaplan Alexander , D’Andrea Megan R. , Bihun Ivanna , Kaneb Andrew , Dietrich Jorg , Ferry Judith A. , Martinez-Lage Maria , Giobbie-Hurder Anita , Borger Darrell R. , Rodriguez Fausto J. , Frosch Matthew P. , Batchelor Emily , Hoang Kaitlin , Kuter Benjamin , Fortin Sarah , Holdhoff Matthias , Cahill Daniel P. , Carter Scott , Brastianos Priscilla K. , Batchelor Tracy T. 
Published: February 2019

Abstract
The genetic alterations that define primary central nervous system lymphoma (PCNSL) are incompletely elucidated, and the genomic evolution from diagnosis to relapse is poorly understood. We performed whole-exome sequencing (WES) on 36 PCNSL patients and targeted MYD88 sequencing on a validation cohort of 27 PCNSL patients. We also performed WES and phylogenetic analysis of 3 matched newly diagnosed and relapsed tumor specimens and 1 synchronous intracranial and extracranial relapse. Immunohistochemistry (IHC) for programmed death-1 ligand (PD-L1) was performed on 43 patient specimens. Combined WES and targeted sequencing identified MYD88 mutation in 67% (42 of 63) of patients, CDKN2A biallelic loss in 44% (16 of 36), and CD79b mutation in 61% (22 of 36). Copy-number analysis demonstrated frequent regions of copy loss (ie, CDKN2A), with few areas of amplification. CD79b mutations were associated with improved progression-free and overall survival. We did not identify amplification at the PD-1/PD-L1 loci. IHC for PD-L1 revealed membranous expression in 30% (13 of 43) of specimens. Phylogenetic analysis of paired primary and relapsed specimens identified MYD88 mutation and CDKN2A loss as early clonal events. PCNSL is characterized by frequent mutations within the B-cell receptor and NF-κB pathways. The lack of PD-L1 amplifications, along with membranous PD-L1 expression in 30% of our cohort, suggests that PD-1/PD-L1 inhibitors may be useful in a subset of PCNSL. WES of PCNSL provides insight into the genomic landscape and evolution of this rare lymphoma subtype and potentially informs more rational treatment decisions.
TBCRC026: Phase II Trial Correlating Standardized Uptake Value With Pathologic Complete Response to Pertuzumab and Trastuzumab in Breast Cancer
Authors: Connolly Roisin M. , Leal Jeffrey P. , Solnes Lilja , Huang Chiung-Yu , Carpenter Ashley , Gaffney Katy , Abramson Vandana , Carey Lisa A. , Liu Minetta C. , Rimawi Mothaffar , Specht Jennifer , Storniolo Anna Maria , Valero Vicente , Vaklavas Christos , Krop Ian E. , Winer Eric P. , Camp Melissa , Miller Robert S. , Wolff Antonio C. , Cimino-Mathews Ashley , Park Ben H. , Wahl Richard L. , Stearns Vered 
Published: February 2019

PURPOSE Predictive biomarkers to identify patients with human epidermal growth factor receptor 2 (HER2)–positive breast cancer who may benefit from targeted therapy alone are required. We hypothesized that early measurements of tumor maximum standardized uptake values corrected for lean body mass (SULmax) on [18F]fluorodeoxyglucose positron emission tomography/computed tomography would predict pathologic complete response (pCR) to neoadjuvant pertuzumab and trastuzumab (PT). PATIENTS AND METHODS Patients with stage II/III, estrogen receptor–negative, HER2-positive breast cancer received four cycles of neoadjuvant PT. [18F]Fluorodeoxyglucose positron emission tomography/computed tomography was performed at baseline and 15 days after PT initiation (C1D15). Eighty evaluable patients were required to test the null hypothesis that the area under the curve of percentage of change in SULmax by C1D15 predicting pCR is less than or equal to 0.65, with a one-sided type I error rate of 10%. RESULTS Eighty-eight women were enrolled (83 evaluable), and 85% (75 of 88) completed all four cycles of PT. pCR after PT alone was 34%. Receiver operating characteristic analysis yielded an area under the curve of 0.76 (90% CI, 0.67 to 0.85), which rejected the null hypothesis. Between patients who obtained pCR versus not, a significant difference in median percent reduction in SULmax by C1D15 was observed (63.8% v 33.5%; P < .001), an SULmax reduction greater than or equal to 40% was more prevalent (86% v 46%; P < .001; negative predictive value, 88%; positive predictive value, 49%), and a significant difference in median C1D15 SULmax (1.6 v 3.9; P < .001) and higher proportion of C1D15 SULmax less than or equal to 3 (93% v 38%; P < .001; negative predictive value, 94%; positive predictive value, 55%) were observed. CONCLUSION Early changes in SULmax predict response to four cycles of PT in estrogen receptor–negative, HER2-positive breast cancer. Once optimized, this quantitative imaging strategy may facilitate a more tailored approach to therapy in this setting.
Editorial
Authors: Stadtlober Cláudia De Salles , Coelho Arnaldo F. M. , Weersma Laodicéia A. 
Published: February 2019

A gestão organizacional é complexa e proporciona diversos desafios às equipes de trabalho. Há de se perceber as necessidades e os anseios dos clientes, dos investidores, dos acionistas, da sociedade, dos colaboradores e deve-se estar atualizado, buscando inovar, manter-se competitivo e, ao mesmo tempo, colaborativo com a sustentabilidade e o compromisso social. Dentro desse escopo amplo e instigante, a Revista de Gestão em Análise [ReGeA] traz, em sua segunda edição de 2018, temas contemporâneos em diferentes áreas de abordagem da administração. Assim, nesta edição, há onze artigos diferenciados, tanto sob a perspectiva da qualidade, como os assuntos abordados e o próprio e rigor acadêmico; artigos que contribuem para o olhar da Academia e das próprias práticas que evolvem a gestão, perpassando discussões do mercado, da inovação e da cultura. Concomitantemente, a edição traz ainda três ensaios teóricos com elevada qualificação nas discussões e nas reflexões acerca das temáticas envolventes.
Attention deficit hyperactivity disorder in adults and the role of the mental health nurse
Authors: Adams Danielle , Padmore Jane , Singh Promilla 
Published: February 2019

The prevalence of attention deficit and hyperactivity disorder diagnosis appears to have increased in recent years, with much discussion on the subject in the popular press. This article discusses the role of mental health nurses in the management of this often underdiagnosed and undertreated condition in adults, taking account of extended roles such as non-medical prescribers and the recently published clinical guideline by the National Institute for Health and Care Excellence. There is a continued need to support shared decision making, encourage adherence to treatment and reduce the negativity surrounding the use of controlled drugs to manage this condition. Children who have a diagnosis of attention deficit and hyperactivity disorder will generally have had comorbid difficulties considered as part of the diagnosis and treatment plans, with input from education in addition to health and social care. In adulthood, it could be argued that the focus is on managing substance abuse, mood and anxiety disorders, resulting in the diagnosis of attention deficit and hyperactivity disorder being overlooked.
Hong Kong in the Hollywood imaginary: Deterritorialization and reterritorialization in John Woo’s A Better Tomorrow and The Killer
Authors: Dissanayake Wimal 
Published: February 2019

Abstract
This article examines the way Hong Kong figures in the Hollywood imaginary by examining John Woo’s films A Better Tomorrow and The Killer. For the purpose of my investigation, I show how the two films exemplify the twin concepts of deterritorialization and reterritorialization with regard to a variety of analytical categories including genre, gender, values, somatic pleasure, affect, melodrama, religion, nostalgia, morals, and the social and cultural context. My analysis demonstrates the hybrid nature of John Woo’s films and provides evidence that cultural identities are flexible and change as they are faced with different contexts and challenges.
King Hu in Hollywood: Making The Battle of Ono
Authors: Wang George Chun Han 
Published: February 2019

Abstract
The Battle of Ono was supposed to be King Hu’s American feature debut. But after more than two decades of devoted efforts to develop and finance this ambitious project, King Hu suddenly passed away before principal photography could begin. Now, more than twenty years since his death, there exists no in-depth documentations nor comprehensive studies of the great Chinese director’s unfulfilled Hollywood experience. To patch a long void in our knowledge of King Hu’s late-career activities and struggles in Hollywood, this article chronicles the development of The Battle of Ono and King Hu’s dauntless navigations through the American film industry, and examines the significant challenges and incidents King Hu had faced in his pioneering yet futile efforts to conquer Hollywood.