bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships Between Physical Testing and Match Activity Profiles Across the Australian Football League Participation Pathway
Authors: Haycraft Jade A.Z. , Kovalchik Stephanie , Pyne David B. , Robertson Sam 
Published: December 2018

Purpose: To establish levels of association between physical fitness and match activity profiles of players in the Australian Football League (AFL) participation pathway. Methods: Players (N = 287, range 10.9–19.1 y) were assessed on 20-m sprint, AFL agility, vertical jump and running vertical jump, 20-m multistage fitness test (MSFT), and Athletic Abilities Assessment. Match activity profiles were obtained from global positioning system measures: relative speed, maximal velocity, and relative high-speed running. Results: Correlational analyses revealed moderate relationships between sprint (r = .32–.57, P ≤ .05) and jump test scores (r = .34–.78, P ≤ .05) and match activity profiles in Local U12, Local U14, National U16, and National U18s, except jump tests in National U18s. AFL agility was also moderate to strongly associated in Local U12, Local U14, Local U18, and National U16s (r = .37–.87, P ≤ .05) and strongly associated with relative speed in Local U18s (r = .84, P ≤ .05). Match relative speed and high-speed running were moderate to strongly associated with 20-m MSFT in Local U14, Local U18, and National U18s (r = .41–.95, P ≤ .05) and Athletic Abilities Assessment in Local U12 and Local U18s (r = .35–.67, P ≤ .05). Match activity profile demands increased between Local U12 and National U16s, then plateaued. Conclusions: Physical fitness relates more strongly to match activity profiles in younger adolescent and national-level players. Recruiters should consider adolescent physical fitness and match activity profiles as dynamic across the AFL participation pathway.
Does Night Training Load Affect Sleep Patterns and Nocturnal Cardiac Autonomic Activity in High-Level Female Soccer Players?
Authors: Costa Júlio A. , Brito João , Nakamura Fábio Y. , Oliveira Eduardo M. , Costa Ovidio P. , Rebelo António N. 
Published: December 2018

Purpose: To analyze whether exercise training conducted at night disturbs sleep and affects nocturnal cardiac autonomic control in high-level female athletes. Methods: A total of 18 high-level female soccer players (mean [SD] age 20.4 [2.1] y) wore actigraphs and heart-rate (HR) monitors during night sleep throughout night training days (n = 8) and resting days (n = 8), for 3 consecutive weeks. This was a longitudinal study that measured internal training load, sleep, nocturnal cardiac autonomic activity, and well-being ratings prior to training sessions. Results: Training load varied across training days (eg, training impulse range, mean [SD]; effect size, ES [95% confidence interval]: 72.9 [18.8] to 138.4 [29.6] a.u.; F4,62 = 32.331; [.001–.16], large effect; P < .001). However, no differences in subjective well-being ratings were observed, although ES was large. Total sleep time (training days vs resting days: 07:17 [00:47] h vs 07:51 [00:42] h; ES = 0.742 [0.59–0.92], P = .005; moderate effect) and sleep-onset time (00:58 [00:19] h vs 00:44 [00:16] h; ES = 0.802 [0.68–0.94], P = .001; moderate effect) were negatively affected after night training. In addition, small effects were detected for wake-up time, time in bed, and sleep latency (P > .05). No differences were detected in HR variability during sleep (range of lnRMSSD: 4.3 [0.4] to 4.5 [0.4] ln[ms] vs 4.6 [0.3] to 4.5 [0.4] ln[ms]; F3,52 = 2.148; P > .05; [.01–.25], medium effect), but HR during sleep was significantly higher after training days (range of HR: 56 [4] to 63 [7] beats/min vs 54 [4] to 57 [6] beats/min; F2,32 = 15.956; P < .001; [.20–.63], large effect). Conclusion: Overall, the results indicate that exercise training conducted at night may disturb sleep and affect HR, whereas limited effects can be expected in HR variability assessed during sleep in high-level female soccer players.
Incidence of exudative age-related macular degeneration and treatment load under the Korean national health insurance system in 2010–2015
Authors: Rim Tyler Hyungtaek , Yoo Tae Keun , Kim Seo Hee , Kim Dong Wook , Kim Sung Soo 
Published: December 2018

Background/AimThe aim of this study was to estimate the nationwide incidence of clinically diagnosed exudative age-related macular degeneration (AMD) and associated use of ranibizumab and aflibercept in South Korea.MethodsIn this retrospective, population-based cohort study, claims data for 2010–2015 were analysed in a randomly selected sample of 519 661 adults aged ≥40 years. The incidence per 10 000 person-years was estimated, along with the 95% CI. Incident exudative AMD was defined based on the registration code for rare intractable diseases. Use of ranibizumab and aflibercept and the incidence of exudative AMD were recorded.ResultsNine hundred and twelve patients were newly diagnosed with exudative AMD in 2010–2015. The 6-year incidence in the general population aged ≥40 years was 2.9 (95% CI 2.8 to 3.0) per 10 000 person-years. The incidence was highest in individuals aged 75–79 years (12.0, 95% CI 10.3 to 13.8). The incidence was higher in men than in women in all age groups. Six hundred and twenty-five (69%) of the 912 newly diagnosed patients started ranibizumab or aflibercept as a first-line treatment. The average number of injections administered was 6.1 (SD 3.9; minimum of 1 injection and maximum government-supported limit of 14) during 2010–2015; the number increased with increasing government funding support (from 5 to 10 and from 10 to 14 in 2013 and 2014, respectively).ConclusionsThis study describes the incidence of exudative AMD in South Korea and its treatment under the national health insurance system in this country. Its findings could be used for reference purposes and be useful when planning treatment for exudative AMD.
Macular sensitivity in patients with congenital stationary night-blindness
Authors: William Antony , Kohl Susanne , Zeitz Christina , Willmann Gabriel , Zrenner Eberhart , Bartz-Schmidt Karl-Ulrich , Gekeler Florian , Schatz Andreas 
Published: December 2018

AimTo evaluate and correlate mean light sensitivity thresholds (MLST) in patients with congenital stationary night-blindness (CSNB) in comparison with healthy subjects using microperimetry (MP1).MethodsEleven patients with CSNB and 13 healthy subjects were compared. In all subjects, static threshold perimetry was performed using MP1 evaluating the central 6 mm of the retina. This central retinal area was divided into three rings through using the ETDRS grid algorithm with an innermost (1 mm), inner (3 mm) and outer ring (6 mm). The MLSTs were acquired in nine sectors of the ETDRS grid. A comparison of MLST was performed between both groups using a t-test (significance level p<0.005).ResultsA significant reduction of MLST in the fovea (innermost ring, 1 mm) was observed for patients with CSNB (7.2±3.90 dB) in comparison to healthy subjects (19.7±0.75; p<0.0001). Similarly, comparison of MLST in all other sectors (superior/inferior/temporal and nasal) within the inner and outer ring revealed a statistically significant reduction in patients with CSNB compared with healthy subjects (p<0.001).ConclusionsExamination of macular retinal sensitivity intensity using MP1 revealed for the first time a significant reduction of MLST within the central 6 mm of the retina in patients with CSNB compared with healthy subjects. This finding supports MP1 as an additional diagnostic tool when examining patients with retinal dysfunctions such as CSNB.
Long-term efficacy of fractionated conformal radiotherapy for the management of primary optic nerve sheath meningioma
Authors: Pandit Ravi , Paris Liliana , Rudich Danielle S , Lesser Robert L , Kupersmith Mark J , Miller Neil R 
Published: December 2018

Background/AimFractionated conformal radiotherapy (FCRT) is now used to treat vision-threatening optic nerve sheath meningioma (ONSM), but long-term efficacy and safety data are lacking; the purpose of this study was to assess these key data.MethodsThis is a retrospective chart review with prospective follow-up of adult patients treated with FCRT for primary ONSM at four academic medical centres between 1995 and 2007 with ≥10 years of follow-up after treatment.Results16 patients were identified with a mean post-treatment follow-up of 14.6 years (range: 10.5–20.7 years). The mean age at symptom onset was 47.6 years (range: 36–60 years). FCRT was performed at a mean of 2.3 years after symptom onset (range: 0.2–14.0 years). At last follow-up, visual acuity had improved or stabilised in 14 of the 16 (88%) patients, and 11 (69%) had retained or achieved ≥20/40. The mean deviation on automated perimetry remained stable (−14.5 dB pretreatment vs −12.2 dB at last follow-up; p=0.68, n=10). Two (11%) patients had persistent pain, proptosis or diplopia, compared with six (38%) pretreatment (p=0.11). Two (13%) patients developed radiation retinopathy more than 6 months after completion of therapy, one (50%) of whom had worse visual acuity compared with pretreatment. No patient developed tumour involvement or radiation damage in the fellow eye.ConclusionFCRT stabilises or improves visual function in patients with primary ONSM and is associated with a low risk of significant ocular sequelae. This treatment should be considered instead of surgery in patients with primary ONSM who require intervention due to loss of visual sensory and/or ocular motor function.
The effectiveness and cost-effectiveness of a complex community sport intervention to increase physical activity: an interrupted time series design
Authors: Anokye Nana , Mansfield Louise , Kay Tess , Sanghera Sabina , Lewin Alex , Fox-Rushby Julia 
Published: December 2018

ObjectivesAn effectiveness and cost-effectiveness analyses of two-staged community sports interventions; taster sports sessions compared with portfolio of community sport sessions.DesignQuasi-experiment using an interrupted time series design.SettingCommunity sports projects delivered by eight lead partners in London Borough of Hounslow, UK.ParticipantsInactive people aged 14 plus years (n=246) were recruited between May 2013 and February 2014.InterventionsCommunity sports interventions delivered in two stages, 6-week programme of taster sport sessions (stage 1) and 6-week programme of portfolio of community sporting sessions delivered by trained coaches (stage 2).Outcome measures(a) Change in days with ≥30 min of self-reported vigorous intensity physical activity (PA), moderate intensity PA, walking and sport; and (b) change in subjective well-being and EQ5D5L quality-adjusted life-years (QALYs).MethodsInterrupted time series analysis evaluated the effectiveness of the two-staged sports programmes. Cost-effectiveness analysis compares stage 2 with stage 1 from a provider’s perspective, reporting outcomes of incremental cost per QALY (2015/2016 price year). Uncertainty was assessed using deterministic and probabilistic sensitivity analyses.ResultsCompared with stage 1, counterfactual change at 21 days in PA was lower for vigorous (log odds: −0.52; 95% CI −1 to –0.03), moderate PA (−0.50; 95% CI 0.94 to 0.05) and sport(−0.56; 95% CI −1.02 to –0.10). Stage 2 increased walking (0.28; 95% CI 0.3 to 0.52). Effect overtime was similar. Counterfactual change at 21 days in well-being was positive particularly for ‘happiness’ (0.29; 95% CI 0.06 to 0.51). Stage 2 was more expensive (£101 per participant) but increased QALYs (0.001; 95% CI −0.034 to 0.036). Cost per QALY for stage 2 was £50 000 and has 29% chance of being cost-effective (£30 000 threshold).ConclusionCommunity-based sport interventions could increase PA among inactive people. Less intensive sports sessions may be more effective and cost-effective.
Biallelic mutations in USP45, encoding a deubiquitinating enzyme, are associated with Leber congenital amaurosis
Authors: Yi Zhen , Ouyang Jiamin , Sun Wenmin , Xiao Xueshan , Li Shiqiang , Jia Xiaoyun , Wang Panfeng , Zhang Qingjiong 
Published: December 2018

BackgroundLeber congenital amaurosis (LCA) is the earliest and most severe form of inherited retinal dystrophies. In approximately 56% of Chinese probands, genetic defects can be detected in known LCA-causing genes. In this study, the objective was to identify pathogenic variants in two unsolved Chinese families with LCA.MethodsTo identify the genetic defect, whole-exome sequencing (WES) and clinical analysis was performed in both probands with LCA as well as in 3011 in-house controls with other hereditary eye diseases. The expression profiles, as well as the phenotype analysis of knockdown zebrafish model and knockout mice model, were performed to investigate the function of USP45 in photoreceptors.ResultsBy analysing WES data based on allele frequencies of in-house controls, population allele frequencies and in silico prediction tools, two rare homozygous mutations in USP45 were identified in two unrelated families. Immunohistochemistry of USP45 in the human and zebrafish retinal sections revealed enriched expression in the inner segments of photoreceptors. The knockdown of usp45 transcript in zebrafish led to abnormal retinal development with effects on photoreceptors, which could be successfully rescued by wild-type usp45 mRNA. Moreover, targeted knockout of Usp45 in mice caused abnormal electroretinography responses, similar to that seen in patients with LCA.ConclusionsOur study implicates that biallelic mutations in USP45 are associated with the occurrence of LCA. Moreover, our results indicate that USP45 is indispensable to the maintenance of photoreceptor function.
A Reinforcement Learning Approach for Solving the Mean Variance Customer Portfolio in Partially Observable Models
Authors: Asiain Erick , Clempner Julio B. , Poznyak Alexander S. 
Published: December 2018

In problems involving control of financial processes, it is usually complicated to quantify exactly the state variables. It could be expensive to acquire the exact value of a given state, even if it may be physically possible to do so. In such cases it may be interesting to support the decision-making process on inaccurate information pertaining to the system state. In addition, for modeling real-world application, it is necessary to compute the values of the parameters of the environment (transition probabilities and observation probabilities) and the reward functions, which are typically, hand-tuned by experts in the field until it has acquired a satisfactory value. This results in an undesired process. To address these shortcomings, this paper provides a new Reinforcement Learning (RL) framework for computing the mean-variance customer portfolio with transaction costs in controllable Partially Observable Markov Decision Processes (POMDPs). The solution is restricted to finite state, action, observation sets and average reward problems. For solving this problem, a controller/actor-critic architecture is proposed, which balance the difficult tasks of exploitation and exploration of the environment. The architecture consists of three modules: controller, fast-tracked portfolio learning and an actor-critic module. Each module involves the design of a convergent Temporal Difference (TD) learning algorithm. We employ three different learning rules to estimate the real values of: (a) the transition matrices [Formula: see text], (b) the rewards [Formula: see text] and (c) the resources destined for carrying out a promotion [Formula: see text]. We present a proof for the estimated transition matrix rule [Formula: see text] and showing that it converges when t → ∞. For solving the optimization programming problem we extend the c-variable method for partially observable Markov chains. The c-variable is conceptualized as joint strategy given by the product of the control policy, the observation kernel Q(y|s) and the stationary distribution vector. A major advantage of this procedure is that it can be implemented efficiently for real settings in controllable POMDP. A numerical example illustrates the results of the proposed method.
Answering children's questions about computers
Authors: Robertson Judy 
Published: December 2018

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Judy Robertson addresses the disconnect between what children are taught about computers and what they actually wish to know.
Managing free-living hyperglycemia with exercise or interrupted sitting in type 2 diabetes
Authors: Blankenship Jennifer M. , Chipkin Stuart R. , Freedson Patty S. , Staudenmayer John , Lyden Kate , Braun Barry 
Published: December 2018

Breaking up sitting with light physical activity (PA) is effective in reducing hyperglycemia in the laboratory. Whether the same effects are observed in the free-living environment remains unknown. We evaluated how daily and postprandial glycemia is impacted by 20, 40, or 60 min of activity performed as either breaks from sitting after each meal (BR) or as one continuous walk after breakfast (WALK). Thirty individuals with type 2 diabetes completed three experimental conditions [BR, WALK, and control (CON)] in a randomized crossover design. Conditions were performed in a free-living environment with strict dietary control over 7 days. Participants increased PA in BR and WALK by 20, 40, or 60 min ( n = 10 in each group) and maintained habitual levels of PA during CON. A continuous glucose monitor (iPro2) and activPAL activity monitor were worn to quantify glycemic control and PA. Using linear mixed models with repeated measures, we 1) compared postprandial glucose (PPG) across conditions and 2) assessed the relationship between activity volume and glucose responses. Whereas WALK tended to shorten the daily duration of hyperglycemia compared with CON ( P = 0.0875), BR was not different from CON. BR and WALK significantly attenuated the breakfast PPG versus CON ( P ≤ 0.05), but lunch and dinner PPG were unaffected by BR and WALK. In conclusion, continuous walking was more effective than breaks from sitting in lowering daily hyperglycemia for the group, but both conditions lowered breakfast PPG. In contrast to tightly controlled laboratory studies, breaks from sitting did not lower hyperglycemia in the free-living environment. NEW & NOTEWORTHY Our “ecolabical” approach is new and noteworthy. This approach combines the external validity of the free-living environment (ecological) with the control of key confounding variables in the laboratory and allows for highly translatable findings by minimizing confounding variables. We found that both postmeal continuous walking and short breaks from sitting similarly attenuated the postprandial glucose (PPG) response to breakfast. Unlike previous laboratory studies, neither condition (walk after breakfast or postmeal breaks) significantly impacted PPG at lunch or dinner.
Type 2 diabetes mellitus in the Goto-Kakizaki rat impairs microvascular function and contributes to premature skeletal muscle fatigue
Authors: Frisbee Jefferson C. , Lewis Matthew T. , Kasper Jonathan D. , Chantler Paul D. , Wiseman Robert W. 
Published: December 2018

Despite extensive investigation into the impact of metabolic disease on vascular function and, by extension, tissue perfusion and organ function, interpreting results for specific risk factors can be complicated by the additional risks present in most models. To specifically determine the impact of type 2 diabetes without obesity on skeletal muscle microvascular structure/function and on active hyperemia with elevated metabolic demand, we used 17-wk-old Goto-Kakizaki (GK) rats to study microvascular function at multiple levels of resolution. Gracilis muscle arterioles demonstrated blunted dilation to acetylcholine (both ex vivo proximal and in situ distal arterioles) and elevated shear (distal arterioles only). All other alterations to reactivity appeared to reflect compromised endothelial function associated with increased thromboxane (Tx)A2 production and oxidant stress/inflammation rather than alterations to vascular smooth muscle function. Structural changes to the microcirculation of GK rats were confined to reduced microvessel density of ~12%, with no evidence for altered vascular wall mechanics. Active hyperemia with either field stimulation of in situ cremaster muscle or electrical stimulation via the sciatic nerve for in situ gastrocnemius muscle was blunted in GK rats, primarily because of blunted functional dilation of skeletal muscle arterioles. The blunted active hyperemia was associated with impaired oxygen uptake (V̇o2) across the muscle and accelerated muscle fatigue. Acute interventions to reduce oxidant stress (TEMPOL) and TxA2 action (SQ-29548) or production (dazmegrel) improved muscle perfusion, V̇o2, and muscle performance. These results suggest that type 2 diabetes mellitus in GK rats impairs skeletal muscle arteriolar function apparently early in the progression of the disease and potentially via an increased reactive oxygen species/inflammation-induced TxA2 production/action on network function as a major contributing mechanism. NEW & NOTEWORTHY The impact of type 2 diabetes mellitus on vascular structure/function remains an area lacking clarity. Using diabetic Goto-Kakizaki rats before the development of other risk factors, we determined alterations to vascular structure/function and skeletal muscle active hyperemia. Type 2 diabetes mellitus reduced arteriolar endothelium-dependent dilation associated with increased thromboxane A2 generation. Although modest microvascular rarefaction was evident, there were no other alterations to vascular structure/function. Skeletal muscle active hyperemia was blunted, although it improved after antioxidant or anti-thromboxane A2 treatment.