bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta Analisis Hasil Penelitian Model-Model Rehabilitasi Narkoba oleh Lembaga Pemerintah, Masyarakat dan Pesantren di Jabodetabek
Authors: Firdaus Ismet 
Published: December 2018

The rehabilitation victims of drug abuse in Indonesia is not only done by government agencies, but also by NGOs and Pesantren. With this type of study, meta-analysis of 15 analytical research report, the results illustrated that in government agencies and non-governmental organizations, program therapeutif community (TC) becomes an important part in the Social Rehabilitation to clients of drug abusers, with the support of family and interaction among clients/patients harmony in social rehabilitation program is an important factor for the improvement or cure the patient/client victims of drug abuse. Detoxification (expenditure toxins drugs to patients/clients) that exist in government agencies and NGOs about the same, while in boarding school detoxification is different, for example by drinking water prayer. Meanwhile, the rehabilitation program in Islamic schools put more emphasis on improving the client’s relationship with God through the practice of worship ritual which he believed to be implicated in healing drug abusers clients.Keywords: Meta analisis, Rehabilitasi Medis, Rehabilitasi Sosial, Theraputif Community dan Narkoba.
Peningkatan Kualitas Minyak Nilam (Pogostemon Cablin Benth) menggunakan Kombinasi Metode Fermentasi, Delignifikasi dan Destilasi
Authors: Muharam Salih , Yuningsih Lela Mukmilah , Rohana Iim Sulaeman 
Published: November 2018

Penyulingan minyak nilam tradisional dilakukan dalam kapasitas kecil dan menggunakanmetode penyulingan sederhanaberdasarkan pada perbedaan titik didih yang jauh atau salah satu komponen bersifat volatil. Proses ini menghasilkan kualitas minyak nilam kurang baik seperti bilangan asam lebih dari 8, minyak berwarna gelap, patchouli alkohol kurang dari 30%, dan kadarair tinggi.Pada penelitian ini telah dilakukan penyulingan minyak dari tanaman nilammenggunakan kombinasi metode yaitu fermentasi-delignifikasi, destilasi dan pemurnian untuk meningkatkan kualitas minyak nilam. Hasil penelitian ini menunjukan bahwa kombinasi proses fermentasi-delignifikasi-destilasi-adsorpsi menghasilkan kualitas minyak nilam yang lebih baik dengan kualitas bilangan asam, kandungan patchouli alkohol, kadar air dan bobot jenis berturut-turut adalah 7.48, 35.60%, 0.56%,0.0957. The traditional distillationof patchouli oil conducted in small capacity and using a simple distillation method based on differences of wide a boiling point or one component is volatile. This process results a poor quality of patchouli oils such as the acid numbers is more than 8, dark-colored oils, patchouli alcohols contentis less than 30%, and high water content. In this research has been done oil distillation from patchouli plants using a combination of methods i.e. fermentation-delignification, distillation and purification to improve of patchouli oil quality. The results show that the combination of the fermentation-delignification-distillation-adsorptionis better in quality of patchouli oil with the acid number, patchouli alcohol content, water content and density were 7.48, 35.60%, 0.56%, and 0.0957 respectively.
Screening Marker Components Of Tyrosinase Inhibitor From Xylocarpus Granatum Stem
Authors: Darusman Latifah K , Batubara Irmanida , Lopolisa Catharina 
Published: November 2018

The aim of our research was to screen the marker components of tyrosinase inhibitor from Xylocarpus granatum stem collected from Pulau Sebuku, South Kalimantan, Indonesia. The screening method started from selection of part of X. granatum, stem or stem bark. Stem and stem bark of X. granatum were dried and grounded before submitted to methanol. The stem extracts is more potent as tyrosinase inhibitor (IC50 for monophenolase is 45.12 μg/ml and diphenolase is 31.59μg/ml) compared to the bark extracts. The IC50 values of kojic acid as positive control are 17.43μg/ml for monophenolase and 20.69 μg/ml for diphenolase. The stem extract then separated with silica gel column chromatography and preparative thin layer chromatography. The results showed that component with Rf 0,25 and 0.63 (TLC analysis with stationary phase silica gel GF254 and mobile phase ethyl acetic: methanol (8:2)) are the marker components as tyrosinase inhibitor for X. granatum.
Peningkatan Kemurnian Radiokimia Iodium-125 Produksi PRR dengan Natrium Metabisulfit dan Reduktor Jones
Authors: Maiyesni Maiyesni , Mujinah Mujinah , Witarti Witarti , Dede K Dede K , Triani W Triani W , Trianto Trianto 
Published: November 2018

Radioisotop 125iodium cukup dikenal luas manfaatnya, diantaranya adalah sebagai perunut (tracer) kit RIA/IRMA untuk deteksi in-vitro berbagai penyakit, sebagai sumber radiasi dalam brachytherapy penyakit kanker, sebagai perunut binding assay dalam berbagai penelitian bioteknologi. Beberapa tahun lalu untuk memenuhi kebutuhan dalam negeri 125I masih diimpor. BATAN, telah memiliki fasilitas produksi radioisotop 125I, tetapi sampai dua tahun terakhir selain efisiensi produksi belum optimal, kualitas produk belum memenuhi persyaratan untuk banyak keperluan di atas. 125I yang digunakan pada bidang kesehatan dalam bentuk larutan Na125-I harus memiliki kemurnian radiokimia tinggi (>95 %) agar mendapatkan hasil penandaan yang baik. Dengan demikian perlu dilakukan peningkatan kemurnian radiokimia 125I- dengan mengurangi pengotor radiokimia yang berasal pengotor ion iodat dan ion periodat. Pada penelitian ini digunakan Na2S2O5 dan reduktor Jones untuk mereduksi ion iodat dan ion periodat menjadi ion iodida. (Na125-I) produksi PRR-BATAN sampai batas yang diharapkan. Pada percobaan ini diperoleh kemurnian radiokimia 125I- 91,49 % dengan penambahan Na2S2O5 0,1 N volume 6 uL, dan 95,16% dengan volume 8 uL. Penggunaan Na2S2O5 dengan konsentrasi 0,3 N volume 2 uL diperoleh kemurnian radiokimia 99 % sedangkan volume 4 uL, 6 uL, dan 8 uL menghasilkan kemurnian radiokimia 100 %. Sedangkan penggunaan reduktor Jones menghasilkan kemurnian radiokimia 125I- yaitu 99,83 %. Kata Kunci: iodium-125, kemurnian radiokimia, Na2S2O5, reduktor Jones, iodat.
Sintesis Tris(4-metoksifenil)tolilsilan dengan Teknik Reaksi Kopling Menggunakan Katalis Paladium Tersier Tributil Fosfin
Authors: Lesbani Aldes , Mohadi Risfidian , Eliza Eliza 
Published: November 2018

Telah disintesis senyawa tris(4-metoksifenil)tolilsilan (TMT) dengan teknik reaksi kopling menggunakan tolilsilan dan 4-iodida anisol yang dikatalis senyawa paladium. Reaksi dilakukan dalam kondisi inert dan suasana basa. Senyawa TMT hasil sintesis dikarakterisasi menggunakan kromatografi gas-spektrometri massa dan spektrometer 1H dan 13C NMR. Hasil penelitian menunjukkan bahwa senyawa TMT hasil sintesis memiliki rendemen sebesar 30%. Pengukuran menggunakan kromatografi gas-spektrometri massa menghasilkan nilai m/z sebesar 440. Spektrum 1H NMR menunjukkan lima puncak proton ekivalen dan spektrum 13C NMR menghasilkan sepuluh puncak karbon ekivalen. Hasil karakterisasi tersebut bersesuaian dengan struktur senyawa TMT hasil sintesis. Kata kunci: tris(4-metoksifenil)tolilsilan, reaksi kopling, paladium
Adsorpsi Pb2+ dan Cu2+ Menggunakan Kitosan-Silika dari Abu Sekam Padi
Authors: Mulyasuryani Ani , Rumhayati Barlah , Cahyani Chandrawati , Soebiantoro Soebiantoro 
Published: November 2018

Abstrak Silika dari abu sekam padi yang dimodifikasi dengan kitosan menghasilkan suatu adsorben yang dapat meningkatkan daya adsorpsi terhadap ion logam. Adsorben kitisan – silika dari abu sekam padi dibuat dengan komposisi 100, 95, 85, 75 dan 65 % silika dalam kitosan. Hasil penelitian menunjukkan bahwa peningkatan jumlah kitosan dapat meningkatkan nilai kapasitas tukar kation (KTK) adsorben. Adsorben terbaik dihasilkan pada % silika 65% dengan KTK 0,45 mekiv H+/g adsorben. Adsorbent tersebut mempunyai daya adsorpsi terhadap Pb2+ sebesar 11,8 mg/g adsorben dan 0,3 mg/g adsorben terhadap Cu2+. Kata kunci : adsorpsi, abu sekam padi, kapasitas tukar kation, kitosan Abstract Modification of silica from rice husk ash with chitosan resulted a high capacity adsorbant. The composition of silica from rice husk ash in adsorbent are 100, 95, 85, 75, and 65% in chitosan. The result of researsh show that the chitosan increasing cation exchange capasity (CEC) of adsorbent. The best adsorbent is 65% silica with CEC 0,45 mekiv H+/g adsorbent. The adsorbent has ability to adsorb Pb2+ is 11,8 mg/g adsorben and 0,3 mg/g adsorben to Cu2+. Keywords : adsorption, rice ash husk, cation exchange capacity, chitosan
Isolasi Dan Identifikasi Terpenoid dari Fraksi n-Butanol Herba Lampasau (Diplazium esculentum Swartz)
Authors: Astuti Maria Dewi , Kuntorini Evi Mintowati , Wisuda Farah Eka Putri 
Published: November 2018

Abstrak Telah dilakukan penelitian yang bertujuan untuk mengidentifikasi senyawa kimia yang diisolasi dari fraksi n-butanol ekstrak metanol herba lampasau (Diplazium esculentum Swartz). Ekstrak metanol diperoleh secara maserasi dan difraksinasi berturut-turut denganpetroleum eter, etil asetat, dan n-butanol. Fraksi n­-butanol difraksinasidengan kromatografi kolom dengan fase diam silika gel dihasilkan fraksi A, B, C, dan D. Fraksi B dimurnikan dengan kromatografi lapis tipis preparatif pada silika geldihasilkan isolat B1. Isolat B1 berupa padatan tidak berwarna danberfluoresensi putih di bawah lampu UV 366 nm. Panjang gelombang maksimum pada spektra UV isolat B1 adalah 225 nm dan 272.5 nm yang menunjukkan adanya ikatan rangkap tak terkonjugasi. Spektra IR isolat B1 menunjukkan adanya gugus C=C, –OH, C=O lakton, –CO, C–H ulur, dan C–H tekuk. Spektra 1H-NMR isolat B1 menunjukkan sinyal proton pada ikatan rangkap, proton –OH, proton pada –CH2 yang terikat atom oksigen, serta proton gugus metil –CH3. Berdasarkan data spektra UV, IR, dan 1H-NMR maka isolat B1 disarankan sebagai turunan senyawa triterpenoid hopan-lakton. Kata kunci : diplazium esculentum Swartz, fraksi n-butanol, triterpenoid hopan-lakton Abstract The research aims to identify chemical compounds isolated fromn-butanol fraction methanol extract of lampasau herbs (Diplazium esculentum Swartz). The methanol extract was obtained by maceration and fractioned by petroleum ether, ethyl acetate, andn-butanol. N-butanol fraction was fractionated using column chromatography on silica gel produced fractions A, B, C, and D. Fraction B was purified by preparative thin layer chromatography on silica gel produced isolate B1. Isolate B1was colorless solid and has white fluorescent under UV lamp 366 nm. The maximum wavelength on UV spectra of B1 are 225 nm and 272,5 nm indicates the unconjugated double bond. IR spectra of B1 showed the vibration of C=C, –OH, C=O lactone, –CO, C–H stretching and C–H bending. Signals of 1H-NMR spectra of B1 showed the proton of double bond, –OH proton, –CH2 proton bounded on oxygen atom, and –CH3 methyl proton. Based on data of spectra UV, IR, and 1H-NMR, isolate B1 suggested as a hopan triterpen derivative. Keywords : diplazium esculentum Swartz, n-butanol fraction, hopan-lactone triterpene
Transcription of Cell Wall Mannoproteins-1 gene in Saccharomyces cerevisiae Mutant
Authors: Hermansyah Hermansyah 
Published: December 2018

Protein phosphatase (PPases) are enzymes to catalyze the phosphate groups removal from amino acid residues of proteins by protein kinases. The PPG1, one of PPases in Saccharomyces cerevisiae has less information in function/role. In this research, the disruption of DPPG1::CgHIS3 in FY833 genetic background was successfully constructed by PCR-mediated disruption strategies using pCgHIS3 (EcoRI-HindIII) (=pYMS314) (pUC19 base) and primer pair of PPG1, forward (41 to 100) and reverse (1048 to 1101). A BamHI - BamHI fragment 3,28 kb DPPG1::CgHIS3 consisting of 1 kb upstream PPG1+ 1.78 kb CgHIS3 + 0.5 down stream of PPG1) was confirmed using PCR and detected using electrophoresis. Phenotypic assay of DPPG1::CgHIS3 in FY833 and did not show 200mg/ml Calco fluor sensitivity, while another mutant DPPG1::CgHIS3 in W303-IA show 100mg/ml congo red sensitivity. Furthermore, to confirm whether DPPG1 could increase a CWP1 transcriptional level was performed Real Time (RT) PCR analysis using Primer pair Kf (AATTCGGCCTGGTGAGTATCC) and Kr (GTTTCAAAGTGCCGTTATCACT GT). RT-PCR’s data showed that transcriptional level of CWP1 in DPPG1::CgHIS3 changed less than two-folds comparing with in wild type strain. This result indicated that disruption of PPG1 in S.cerevisiae did not change CWP1 transcriptional level significantly.
Length of Stay and Complications Associated With Febrile Infants &lt;90 Days of Age Hospitalized in the United States, 2000–2012
Authors: Nguyen Diana K. , Friedlander Scott , Fleischman Ross J. , Zangwill Kenneth M. 
Published: November 2018

OBJECTIVES:It is not known how changes in the epidemiology of serious bacterial infection (SBI) and greater availability of rapid viral diagnostic tests have impacted the hospital length of stay (LOS) and associated complications among young infants with suspected SBI.METHODS:We used national administrative data from the Healthcare Cost and Utilization Project Kids’ Inpatient Database and other state-specific data to identify febrile infants &lt;90 days of age hospitalized in 2000, 2003, 2006, 2009, and 2012. We used multivariate analysis to determine LOS, risk factors for prolonged LOS, and complications of care among infants with isolated fever or viral respiratory disease, without concomitant serious infection.RESULTS:We identified 44 875 infants. LOS for each clinical group did not change over time in a clinically significant way. Mean LOS was ≤2 days for approximately two-thirds of all infants and ≥4 days for 11% in each clinical group. Factors associated with longer LOS included age &lt;31 days, critical clinical status, concomitant chronic disease, and the presence of complications (P &lt; .05). We identified 289 (0.8%) infants with 351 complications of care, 18 (6%) of whom had &gt;1. These infants had longer LOS (P &lt; .001), and those with chronic disease and older age were at increased risk (P &lt; .01).CONCLUSIONS:Despite the changing epidemiology of SBI and increased availability of viral diagnostic testing, we did not detect a clinically significant change in LOS for febrile infants with suspected SBI. Complications associated with hospitalization of these infants was associated with increased LOS.
Más allá de los síntomas: vivir con VIH es motor de cambio
Authors: Bastidas Erazo Ana María , Canaval Gladys Eugenia 
Published: November 2018

Objetivo: describir en profundidad la experiencia de personas con VIH durante el proceso de tratamientoy atención en instituciones de salud. Materiales y métodos: diseño de teoría fundamentada en entrevistas en profundidad a once personas con VIH que asistían a programas de atención ambulatoria en Cali, Colombia.Resultados: categoría central denominada: vivir con VIH es motor para el cambio de vida y seis categorías: experimentando los síntomas; sospechando el diagnóstico; recordando información sobre ser portadordel VIH; experimentando crisis existencial: el poder de las emociones; reconociendo la bondad de los medicamentosy obteniendo apoyo social: considerado aspecto fundamental.Conclusión: los participantes al recibir el diagnóstico experimentaron crisis existencial y emocional que conla ayuda de familiares, personal de salud, la pareja y los pares, les facilitó tomar conciencia de su estado actualy aceptar su situación; sus hábitos se tornaron saludables y la creencia en un ser superior se reafirmó.
Sex-Related Disparities in CKD Progression
Authors: Ricardo Ana C. , Yang Wei , Sha Daohang , Appel Lawrence J. , Chen Jing , Krousel-Wood Marie , Manoharan Anjella , Steigerwalt Susan , Wright Jackson , Rahman Mahboob , Rosas Sylvia E. , Saunders Milda , Sharma Kumar , Daviglus Martha L. , Lash James P. ,   on behalf of the CRIC Investigators
Published: December 2018

Background
In the United States, incidence of ESRD is 1.5 times higher in men than in women, despite men’s lower prevalence of CKD. Prior studies, limited by inclusion of small percentages of minorities and other factors, suggested that men have more rapid CKD progression, but this finding has been inconsistent.

Methods
In our prospective investigation of sex differences in CKD progression, we used data from 3939 adults (1778 women and 2161 men) enrolled in the Chronic Renal Insufficiency Cohort Study, a large, diverse CKD cohort. We evaluated associations between sex (women versus men) and outcomes, specifically incident ESRD (defined as undergoing dialysis or a kidney transplant), 50% eGFR decline from baseline, incident CKD stage 5 (eGFR<15 ml/min per 1.73 m2), eGFR slope, and all-cause death.

Results
Participants’ mean age was 58 years at study entry; 42% were non-Hispanic black, and 13% were Hispanic. During median follow-up of 6.9 years, 844 individuals developed ESRD, and 853 died. In multivariable regression models, compared with men, women had significantly lower risk of ESRD, 50% eGFR decline, progression to CKD stage 5, and death. The mean unadjusted eGFR slope was −1.09 ml/min per 1.73 m2 per year in women and −1.43 ml/min per 1.73 m2 per year in men, but this difference was not significant after multivariable adjustment.

Conclusions
In this CKD cohort, women had lower risk of CKD progression and death compared with men. Additional investigation is needed to identify biologic and psychosocial factors underlying these sex-related differences.
SERVİKS KANSERİNDE PRİMER KEMORADYOTERAPİ SONRASI UTERUSTA SINIRLI REZİDU TÜMÖRÜN SAĞKALIMA OLAN ETKİSİ
Authors: Sözen Hamdullah , BAKTIROGLU Merve , YUMRU Harika , USTA İrem , YALÇIN İbrahim , KUCUCUK Seden , IBIS Kamuran , TOPUZ Samet , SALİHOGLU Yavuz 
Published: December 2018

ÖZET:Amaç: Primer kemoradyoterapi
tedavisi almış ileri evre serviks kanserli hastalarda uterusa sınırlı rezidü
tümör miktarının sağkalıma etkisini belirlemek ve bu tarz tümörlerde görüntüleme
yöntemlerinin rezidü tümör saptamadaki başarısı saptamakMateryal Metod: İstanbul
Universitesi İstanbul Tıp Fakültesi Jinekolojik Onkoloji Kliniğinde 2009 Nisan-2017
Mayıs ayları arasında opere edilen 31 hasta çalışmaya dahil edilmiştir. Bu
hastaların klinikopatolojik özellikleri değerlendirilmiştir. Hastalar operasyon
öncesi Magnetik Rezonans inceleme (MRI) ve/veya Pozitron Emisyon Tomografi
(PET-BT) ile değerlendirilmiştir. Hastalar operasyon sonrası uterus
materyalinde tümör miktarına göre i) rezidu tümör yok ii) rezidü tümör &lt;10
mm iii) rezidü tümör &gt; 10 mm olarak üç gruba ayrılmış ve hastalıksız sağkalım incelemesi yapılmıştır.Sonuçlar: Ortanca yaş
54 olarak hesaplanmıştır. MRI rezidü tümör saptamada sensitivitesi %75
spesifitesi %50 ; PET-BT sensitivitesi
%54.5 spesifitesi %50 olarak saptanmıştır. Bir yıllık hastalıksız sağkalım
oranları rezidü olmayan, mikroskobik rezidü olan ve makroskobik rezidü olan
hastalarda sırası ile %92.3, %80 ve %38.5 olarak tespit edildi.

Yorum: Irradiye serviks kanserinde rezidü tümör saptamada
görüntüleme yöntemlerinin başarısı kısıtlıdır. Histopatolojik olarak saptanmış
rezidü tümörün büyüklüğü arttıkça hastalıksız sağkalım rakamları azalmaktadır.
Comparative effectiveness analysis of the enucleation, enucleoresection and resection implementation in intrasinus non-formation of the kidney
Authors: Spot’ E. V. , Mashin G. A. , Rapoport L. M. , Tsarichenko D. G. , Kudryavtsev A. D. 
Published: December 2018

The study objective is to perform comparative analysis of the effectiveness of enucleation, enucleoresection, and resection in renal sinus tumors.Materials and methods. Examination and treatment of 55 patients aged 28–74 years with intrasinous neoplasms of the kidneys of T1–T3 stage was carried out to perform a comparative analysis of the various operations effectiveness: 28 patients underwent organ-preserving operations (enucleation and enucleoresection), 27 – resection. Both groups were statistically comparable by sex, age, location, tumor volume. The most frequent histological variant of the tumor for any type of operation was clear-cell carcinoma (73 %).Results and conclusion. It is established that organ-preserving operations, unlike resection, involve a significantly shorter time of thermal ischemia, allowing the operation to be performed under conditions of zero-ischemia. This was accompanied by an improvement in treatment outcomes, a significant regression in the number of intraoperative and postoperative complications.
Ortaokul Matematik Öğretmen Adaylarının Matematiksel Modelleme Yeterliklerinin Cinsiyete Göre İncelenmesi: Çok Boyutlu Madde Tepki Kuramı
Authors: DEDE Yüksel , AKÇAKIN Veysel , KAYA Gürcan 
Published: December 2018

Bu
çalışmanın amacı, ortaokul matematik öğretmen adaylarının matematiksel
modelleme yeterliklerinin belirlenmesidir. Bu amaç doğrultusunda; nedensel
karşılaştırma araştırması olarak desenlenen bu çalışmada, ortaokul matematik
öğretmen adaylarının matematiksel modelleme yeterlikleri incelenmiş ve
cinsiyet faktörünün bu yeterlikler üzerinde istatistiksel olarak anlamlı bir
farklılık oluşturup oluşturmadığı belirlenmiştir. Çalışmanın katılımcıları,
seçkisiz olmayan örnekleme yöntemlerinden kolay ulaşılabilir örnekleme yöntemi
ile belirlenen 144’ü kadın ve 63’ü erkek olmak üzere 207 ortaokul matematik
öğretmen adayından oluşmuştur. Araştırma sonuçları, ortaokul matematik öğretmen adaylarının
genel matematiksel modelleme yeterliği, problemi yapılandırma, değişkenleri
belirleme ile yorumlama-doğrulama yeterliklerinin negatif logit değerleri,
matematik modeli oluşturma ve matematik çalışma yeterliklerinin ise pozitif
logit değerleri aldıklarını göstermektedir. Öğretmen adaylarının matematik
modeli oluşturma matematiksel modelleme alt yeterliğinin en yüksek logit
değeri, yorumlama-doğrulama matematiksel modelleme alt yeterliğinin ise en
düşük logit değeri aldığı belirlenmiştir. Ayrıca, cinsiyet faktörünün öğretmen
adaylarının genel matematiksel modelleme yeterliği ve matematiksel modelleme
alt yeterlikleri puanları üzerinde istatistiksel olarak anlamlı bir farklılık
oluşturmadığı da tespit edilmiştir.