bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Evaluation of an Educational Initiative to Improve Hospital Personnel Preparedness to Care for Children with Autism Spectrum Disorder
Authors: Lucarelli Jennifer , Welchons Leah , Sideridis Georgios , Sullivan Nancy R. , Chan Eugenia , Weissman Laura 
Published: May 2018

ABSTRACT:

Objective:
To evaluate the effectiveness of a multimodal educational curriculum on increasing hospital personnel's awareness of successful strategies and comfort in caring for children with autism spectrum disorder (ASD).

Methods:
We developed a 3-part training for front-line staff (i.e., front desk, clinical assistants, and phlebotomists) in 8 outpatient hospital departments frequented by patients with ASD. Following a needs assessment, participants completed an online educational module and then attended an in-person seminar tailored to each department. To evaluate training effectiveness, we administered pre-, immediate post-, and 1 month post-training surveys assessing personnel attitudes, comfort, perceived knowledge, and behaviors around caring for patients with ASD.

Results:
We trained 168 staff members from 8 departments. On the needs assessment, participants (N = 129) reported a mean 2.5 behavioral incidents involving patients with ASD over the previous 3 months; 92% believed that the training would be helpful for their work. Across pre-, immediate- and 1-month post-training surveys, scores improved on all questions related to personnel attitudes about the importance of ASD-friendly care, comfort interacting with patients with ASD, perceived knowledge about ASD, and self-reported frequency of behaviors intended to help children with ASD adjust to the hospital setting (p < 0.05). There was no difference in baseline scores or change in scores between clinical and nonclinical personnel. On a program evaluation (N = 57), 81% rated the training as “very good” or “excellent,” and 87% reported that they would be able to apply training material immediately to their role.

Conclusion:
This training initiative led to improvement in attitudes, comfort level, perceived knowledge, and self-reported behaviors of hospital personnel working with patients with ASD, which was maintained over 1 month.
Isolated Conjunctival Inflammation as a Manifestation of IgG4-Related Disease
Authors: Li Ang , Plesec Thomas P. , Mileti Linda , Singh Arun D. 
Published: May 2018

Purpose:
To report a unique case of isolated conjunctival inflammation from IgG4-related disease (IgG4-RD) confirmed by pathology.

Methods:
A single interventional case of conjunctival IgG4-RD.

Results:
A 63-year-old woman presented with a chronic, solitary, vascularized, tan-colored, and raised conjunctival lesion measuring 7.5 × 8.0 × 1.2 mm located at the temporal bulbar conjunctiva. An excisional biopsy was diagnostic of IgG4-RD based on the classic fibrosis pattern, 120 IgG4-positive plasma cells per high-power field, and an overwhelming majority of IgG4-positive cells among IgG plasma cells. No orbital or systemic involvement was found on clinical examination, imaging, and laboratory workup. The serum IgG4 level was normal (87.1 mg/dL). The patient was free of recurrence at 6-month follow-up.

Conclusions:
Isolated conjunctival inflammation without orbital involvement can be a presentation of IgG4-RD.
Clinical Immersion
Authors: Geist Melissa J. , Sanders Robby , Harris Kevin , Arce-Trigatti Andrea , Hitchcock-Cass Cary 
Published: May 2018

Background
A faculty team from nursing and chemical engineering developed a course that brought together students from each discipline for cross-disciplinary, team-based clinical immersion and collaboration.

Problem
Health care processes and devices are rapidly changing, and nurses are uniquely positioned to be bedside innovators to improve patient care delivery.

Approach
During each clinical immersion, the student teams rotated through various hospital units where they identified problems and worked together in the university's makerspace (iMaker Space) to design and build prototypes to improve health outcomes.

Outcomes
Data from the Critical thinking Assessment Test provided evidence of gains in critical-thinking and problem-solving skills, while the problems identified in the clinical setting and prototypes developed demonstrated the impact of bringing nursing and engineering students together to design innovations.

Conclusions
When challenged to identify authentic problems during their clinical immersion, the teams of nursing and engineering students proposed creative solutions and developed commercially viable prototypes.
Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging
Authors: Martens Dries S. , Cox Bianca , Janssen Bram G. , Clemente Diana B. P. , Gasparrini Antonio , Vanpoucke Charlotte , Lefebvre Wouter , Roels Harry A. , Plusquin Michelle , Nawrot Tim S. 
Published: May 2018

(Abstracted from JAMA Pediatr 2017;171(12):1160–1167)
Telomere length (TL) is considered a molecular marker of biological aging. Telomeres shorten with each cellular division, and their length is associated with age-related diseases, lifestyle factors such as smoking, and environmental factors that influence the oxidative stress and inflammatory status in humans.
Efficacy of Veinlite PEDI in Pediatric Peripheral Intravenous Access
Authors: Gümüş Merve , Başbakkal Zümrüt 
Published: May 2018

Objectives
A previous study by Katsogridakis et al (Pediatr Emerg Care. 2008;24:83–88) evaluated the use of the white light Veinite transillumination device to improve vein access in children. Since then, advanced light emitting diode color lighting has been developed to improve the visualization of veins. To evaluate the efficacy of the new technology, we carried out a study in our pediatric emergency departments using the light emitting diode-based Veinlite PEDI (TransLite, Sugar Land, Tex).

Methods
A total of 112 pediatric patients were enrolled in the study. Children who presented to the emergency department aged 1 to 10 years old were randomly assigned to the Veinlite PEDI (Veinlite) group or standard of care (SoC) group. The primary outcome measure was first attempt success. Secondary outcome measures were number of intravenous (IV) attempts and time to peripheral intravenous catheter (PIC) placement.

Results
A total of 110 patients completed the study: 58 boys and 52 girls. The first attempt success rate was significantly higher in the Veinlite group compared with the SoC group (92.9% vs 72.2%, P < 0.004). In addition, the Veinlite group had a fewer number of attempts compared with the SoC group (1.07 ± 0.54 vs 1.31 ± 0.25, P = 0.04). The Veinlite group resulted in a shorter total time of attempts per patient compared with the SoC group (49.98 ± 18.4 vs 59.68 ± 22.5 P = 0.01).

Conclusions
The use of new technology in the Veinlite PEDI (TransLite, Sugar Land, Tex), to assist with peripheral IV access in children, improves the first time success rate for IV access. Improved visualization of veins also reduced the number of attempts and the time required for PIC placement. These results suggest that the new technology of the Veinlite results in better PIC access than Veinlite transilluminaton device with white light.
Initial Characteristics and Clinical Severity of Hemophagocytic Lymphohistiocytosis in Pediatric Patients Admitted in the Emergency Department
Authors: Lee Jeong-Yong , Kim Jung Heon , Lee Jong Seung , Ryu Jeong-Min , Seo Jong Jin , Im Ho Joon 
Published: May 2018

Objectives
The diagnosis and management of children with hemophagocytic lymphohistiocytosis (HLH) admitted in the emergency department (ED) are challenging. The present study aimed at describing the initial characteristics of pediatric patients with HLH upon admission in the ED. Moreover, the clinical severity of the condition was assessed.

Methods
We performed a retrospective study of patients who visited the pediatric ED and were newly diagnosed with HLH during hospitalization between February 2012 and January 2017. The patients were classified in the clinically unstable group if at least 1 of the following conditions was observed upon admission in the ED: hypoxia requiring oxygen supplementation, hypotension requiring inotropic support, coagulopathy with prothrombin time (international normalized ratio, ≥1.5), and seizures or altered consciousness.

Results
We enrolled 31 pediatric patients with HLH, with a median age of 6.53 years (interquartile range, 1.35–13.24 years). Abdominal discomfort along with fever (74.2%) was the most common presenting symptom in patients admitted in the ED. Based on the HLH-2004 diagnostic criteria, fever (96.8%), hyperferritinemia (96.8%), splenomegaly (74.2%), hypertriglyceridemia and/or hypofibrinogenemia (67.7%), and bicytopenia (41.9%) were observed in the patients. However, only 8 patients (25.8%) met the criteria. Nineteen patients (61.3%) were included in the clinically unstable group. This group had lower albumin (2.3 vs 3.3 g/dL, P = 0.002) and fibrinogen levels and higher ferritin level and neutrophil count than the clinically stable group. Meanwhile, the number of clinical findings that met the diagnostic criteria was not different between the 2 groups. Lower albumin level was a significant risk factor in the clinically unstable group (odds ratio, 0.040; P = 0.004).

Conclusions
Pediatric patients with HLH often have clinically unstable conditions upon admission in the ED. However, only few patients meet the HLH-2004 diagnostic criteria. Lower albumin level may be useful in assessing clinically unstable patients and preparing for possible deterioration.
Fitz-Hugh–Curtis Syndrome in Adolescent Females
Authors: Khine Hnin , Wren Sarah B. , Rotenberg Ohad , Goldman David L. 
Published: May 2018

Abstract
Fitz-Hugh–Curtis syndrome is an extrapelvic manifestation of sexually transmitted infections. Partly because of the lack of specific clinical and laboratory features, this diagnosis is often missed or delayed. We describe a series of cases of patients with Fitz-Hugh–Curtis syndrome, where the diagnosis was initially not recognized and patients underwent extensive evaluations for their symptoms. Based on our experience, we also describe shared historical and physical features that may be useful in enhancing the recognition of patients with this disease.
Understanding Patient Expectations of Lymphedema Surgery
Authors: Fahradyan Artur , El-Sabawi Bassim , Patel Ketan M. 
Published: May 2018

Background:
Patients with lymphedema refractory to medical treatment often have unrealistic expectations for lymphedema surgery. The purpose of this study was to assess patient expectations following lymphedema surgery.

Methods:
Patients presenting to the clinic for initial evaluation for lymphedema surgery were offered to complete a survey designed to evaluate their expectations for limb appearance, limb function, and overall well-being following lymphedema surgery. The patients were instructed to score each item using a five-point scale for improvement. A mean expectation score was calculated, which was then used to estimate the effects of preoperative variables on patients expectations using multiple regression analysis.

Results:
A total of 21 women and two men with a mean age of 60 years completed the survey. The upper limbs were affected in 10 patients and the lower limbs were affected in 13 patients. Physicians were the initial source of information about lymphedema surgery as a potential treatment option in 10 patients (43 percent), and a majority of the patients [n = 15 (65.2 percent)] thought that the physicians had fair or poor knowledge about lymphedema surgery. Significant or complete improvement was expected by 43.4 to 73.9 percent of patients. Patients’ level of education, the disease duration, and the initial source of information about lymphedema surgery had a statistically significant impact on patients’ expectations.

Conclusions:
Early data suggest that most patients learn about lymphedema surgery from nonphysicians, with many expecting complete or significant improvement of lymphedema-associated symptoms with surgery. These findings emphasize the importance of addressing patient expectations and providing appropriate counseling before surgery.
Current Concepts in Orthognathic Surgery
Authors: Naran Sanjay , Steinbacher Derek M. , Taylor Jesse A. 
Published: May 2018

Learning Objectives:
After studying this article, the participant should be able to: 1. Identify skeletal differences that are treated with orthognathic surgery; describe the goals of orthognathic surgery; and understand modern virtual surgical planning of orthognathic movement of the mandible, maxilla, and chin. 2. Appreciate the surgical principles of maxilla- versus mandible-first surgery, and orthognathic surgery before orthodontic correction; and understand when an osseous genioplasty may be beneficial, and the potency of this bony movement. 3. Appreciate the utility of fat grafting as an adjunct to orthognathic bony movements, and demonstrate understanding of the utility of orthognathic surgery in the treatment of obstructive sleep apnea. 4. Be aware of associated complications and be able to critically assess outcomes following orthognathic surgery.

Summary:
This CME article outlines the goals of orthognathic surgery, highlighting advances in the field and current controversies. The principles of the sequencing of osteotomies are discussed and literature is reviewed that may assist in decision-making as to maxilla-first versus mandible-first surgery. The emergence of “surgery first,” in which surgery precedes orthodontics, is discussed and important parameters for patient candidacy for such a procedure are provided. The emerging standard of virtual surgical planning is described, and a video is provided that walks the reader through a planning session. Soft-tissue considerations are highlighted, especially in the context of osseous genioplasty and fat grafting to the face. The utility of orthognathic surgery in the treatment of obstructive sleep apnea is discussed. The reader is provided with the most current data on complications following orthognathic surgery and advice on avoiding such pitfalls. Finally, outcome assessment focusing on the most current trend of patient-reported satisfaction and the psychological impact of orthognathic surgery are discussed.
Molecular phenotyping using networks, diffusion, and topology: soft tissue sarcoma
Authors: Mathews James C , Pouryahya Maryam , Moosmüller Caroline , Kevrekidis Ioannis , Deasy Joseph O , Tannenbaum Allen 
Published: May 2018

AbstractMany biological datasets are high-dimensional yet manifest an underlying order. In this paper, we describe an unsupervised data analysis methodology that operates in the setting of a multivariate dataset and a network which expresses influence between the variables of the given set. The technique involves network geometry employing the Wasserstein distance, global spectral analysis in the form of diffusion maps, and topological data analysis using the Mapper algorithm. The prototypical application is to gene expression profiles obtained from RNA-Seq experiments on a collection of tissue samples, considering only genes whose protein products participate in a known pathway or network of interest. Employing the technique, we discern several coherent states or signatures displayed by the gene expression profiles of the sarcomas in the Cancer Genome Atlas along the p53 signaling network. The signatures substantially recover the leiomyosarcoma, dedifferentiated liposarcoma (DDLPS), and synovial sarcoma histological subtype diagnoses, but they also include a new signature defined by simultaneous activation and inactivation of about a dozen genes, including activation of fibrinolysis inhibitor SERPINE1/PAI and inactivation of p53-family tumor suppressor gene P73 along with cyclin dependent kinase inhibitor 2A CDKN2A/P14ARF.
Luciferase of the Japanese syllid polychaete Odontosyllis umdecimdonta
Authors: Schultz Darrin T. , Kotlobay Alexey A. , Ziganshin Rustam , Bannikov Artyom , Markina Nadezhda M. , Chepurnyh Tatiana V. , Shakhova Ekaterina S. , Palkina Ksenia , Haddock Steven H.D. , Yampolsky Ilia V. , Oba Yuichi 
Published: May 2018

1AbstractOdontosyllis undecimdonta is a marine syllid polychaete that produces bright internal and exuded bioluminescence. Despite over fifty years of biochemical investigation into Odontosyllis bioluminescence, the light-emitting small molecule substrate and catalyzing luciferase protein have remained a mystery. Here we describe the discovery of a bioluminescent protein fraction from O. undecimdonta, the identification of the luciferase using peptide and RNA sequencing, and the in vitro reconstruction of the bioluminescence reaction using highly purified O. undecimdonta luciferin and recombinant luciferase. Lastly, we found no identifiably homologous proteins in publicly available datasets. This suggests that the syllid polychaetes contain an evolutionarily unique luciferase among all characterized luminous taxa.3HighlightsThe polychaete O. undecimdonta uses a luciferin-luciferase bioluminescence systemO. undecimdonta bioluminescence does not require additional cofactorsThe luciferase of the Japanese fireworm is 329 amino acids longRecombinant luciferase is not secreted when expressed in human cellsExogenous luciferin does not seem to penetrate cell membranes-only lysate luminescesThe luciferase transcript is supported by full-length cDNA reads with 5’ and 3’ UTR
Piperazine-based HIV-1 entry inhibitors: Massive in silico library design and screening for gp120 attachment inhibitors
Authors: Castillo-Pazos Durbis J. , Romo-Mancillas Antonio , Barroso-Flores Joaquín 
Published: May 2018

ABSTRACTHIV-1 attachment, despite being an ideal target stage to stop infection from the beginning, remains as one of the HIV lifecycle phases with less amount of designed and commercially available inhibitors. To contribute to the urgently needed discovery of new active compounds that could become part of the current highly active antiretroviral therapy, and as an attempt to explore a massive chemical space, high-throughput virtual screening of 16.3 million combinatorially generated and piperazine-cored compounds, was accomplished. Docking calculations, molecular dynamics simulations, and QSAR analyses were carried out to assess the suitability of each ligand to bind gp120 envelope glycoprotein, thus preventing it from binding to CD4 co-receptor. Ligand 255 stands out as a promising candidate to be tested beyond computational methodologies, and the 4,5,6,7-tetrahydroindole fragment is reported as a better group to bind inside the Phe43 cavity than the substituted indoles reported in the literature.
CD95/Fas ligand mRNA is toxic to cells
Authors: Putzbach William , Haluck-Kangas Ashley , Gao Quan Q. , Sarshad Aishe A. , Bartom Elizabeth T. , Stults Austin M. , Qadir Abdul S. , Hafner Markus , Peter Marcus E. 
Published: May 2018

AbstractCD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported the CD95L mRNA is enriched in sequences that, when converted to si/shRNAs, kill all cancer cells by targeting critical survival genes (Putzbach et al., 2017). We now report expression of full-length CD95L mRNA, itself, is highly toxic to cells and induces a similar form of cell death. We demonstrate that small (s)RNAs derived from CD95L are loaded into the RNA induced silencing complex (RISC) RISC which is required for the toxicity and that processing of CD95L mRNA into sRNAs is independent of both Dicer and Drosha. We provide evidence that in addition to the CD95L transgene a number of endogenous protein coding genes involved in regulating protein translation, particularly under low miRNA conditions, can be processed to sRNAs and loaded into the RISC suggesting a new level of cell fate regulation involving RNAi.
Original brands in competition against high quality copycats
Authors: Nguyen Hang , Gunasti Kunter 
Published: May 2018

Purpose
Copycat brands offering improved product quality pose serious challenges to original brands. This paper aims to provide a better understanding of why consumers prefer copycat brands with superior product attributes and how original brands can shift this preference back by strategically leveraging brand identity cues.

Design/methodology/approach
Four experimental studies test different types of brand identity cues that original brands can use to influence consumer preferences. Logistic and linear regression analyses analyze the effects.

Findings
The results systematically show the power of brand identity cues in helping original brands reduce share loss to copycat brands using superior product attributes. They also reveal the role of brand equity, conspicuous consumption and consumers’ tendency of using brands as status symbols in enhancing the effect of brand identity cues in the face of superior copycats.

Research limitations/implications
This paper extends cue diagnosticity theory and the brand identity literature by showing the power of brand identity cues in predicting consumer choices of original brands.

Practical implications
This paper provides useful guidelines for managers of original brands on how to effectively use brand identity cues to compete against copycats.

Originality/value
Prior research focuses on how copycat brands’ characteristics influence consumers’ evaluations of copycats. These studies are limited, however, by their focus on cheap and low-quality copycats. The current paper examines the effects of brand identity cues and draws attention to the trade-offs consumers make when choosing between original brands and copycats offering superior product features.
Lazy collaborative filtering with dynamic neighborhoods
Authors: G. Suganeshwari , S.P. Syed Ibrahim , Li Gang 
Published: May 2018

Purpose
The purpose of this paper is to address the scalability issue and produce high-quality recommendation that best matches the user’s current preference in the dynamically growing datasets in the context of memory-based collaborative filtering methods using temporal information.

Design/methodology/approach
The proposed method is formalized as time-dependent collaborative filtering method. For each item, a set of influential neighbors is identified by using the truncated version of similarity computation based on the timestamp. Then, recent n transactions are used to generate the recommendation that reflect the recent preference of the active user. The proposed method, lazy collaborative filtering with dynamic neighborhoods (LCFDN), is further scaled up by implementing in spark using parallel processing paradigm MapReduce. The experiments conducted on MovieLens dataset reveal that LCFDN implemented on MapReduce is more efficient and achieves good performance than the existing methods.

Findings
The results of the experimental study clearly show that not all ratings provide valuable information. Recommendation system based on LCFDN increases the efficiency of predictions by selecting the most influential neighbors based on the temporal information. The pruning of the recent transactions of the user also addresses the user’s preference drifts and is more scalable when compared to state-of-art methods.

Research limitations/implications
In the proposed method, LCFDN, the neighborhood space is dynamically adjusted based on the temporal information. In addition, the LCFDN also determines the user’s current interest based on the recent preference or purchase details. This method is designed to continuously track the user’s preference with the growing dataset which makes it suitable to be implemented in the e-commerce industry. Compared with the state-of-art methods, this method provides high-quality recommendation with good efficiency.

Originality/value
The LCFDN is an extension of collaborative filtering with temporal information used as context. The dynamic nature of data and user’s preference drifts are addressed in the proposed method by dynamically adapting the neighbors. To improve the scalability, the proposed method is implemented in big data environment using MapReduce. The proposed recommendation system provides greater prediction accuracy than the traditional recommender systems.