bluuebunny/crossref_metadata_2025_split huggingface dataset:
The evolving consumer IoT: A novel framework for marketing strategy based on assemblage theory
Authors: Hoffman Donna L. , Novak Thomas P. 
Published: November 2024

AbstractThe rapid adoption of generative AI powered by large language models like OpenAI's ChatGPT and Anthropic's Claude promises to disrupt innovation for the consumer Internet of Things (IoT). To understand potential consumer behaviors and marketing strategies, we use an assemblage theory framework to analyze the coevolution of consumer and marketer roles in shaping consumer IoT ecosystems like the smart home. Our framework investigates how different consumer‐ and marketer‐driven territorialization and deterritorialization strategies work to stabilize and destabilize the smart home assemblage. We contrast highly territorialized smart homes characterized by preprogrammed behaviors and clear boundaries, with highly deterritorialized DIY smart homes exhibiting unpredictable behaviors and fuzzy boundaries. Our analysis evaluates how consumers territorialize through habit formation, personalization, and sharing experiences, while marketers territorialize by emphasizing reliability, integration, and clear use cases. Consumers deterritorialize by modifying and hacking devices, and integrating nonstandard products, while marketers deterritorialize by disrupting compatibility or targeting new segments. We also integrate flow theory as an interpretive framework for understanding consumer motivations to territorialize and deterritorialize and argue that the oscillation between states of consumer anxiety and boredom create dynamic smart home identities. Our assemblage theory perspective permits a novel strategic framework that can be applied to anticipate consumer and marketer impacts on smart home evolution.
Long‐Term Follow‐Up of Neuropsychiatric Symptoms After Sustained Virological Response to Interferon‐Free and Interferon‐Based Hepatitis C Virus Treatment
Authors: Dirks Meike , Hennemann Ann‐Katrin , Grosse Gerrit M. , Beer Anika , Pflugrad Henning , Haag Kim , Schuppner Ramona , Deterding Katja , Cornberg Markus , Wedemeyer Heiner , Weissenborn Karin 
Published: November 2024

ABSTRACTChronic hepatitis C virus (HCV) infection can be associated with neuropsychiatric symptoms like fatigue and cognitive impairment, independent of the liver status. The present study aims to assess changes in the pattern and extent of neuropsychological symptoms after successful treatment with interferon (IFN)‐based and IFN‐free therapy. HCV‐infected patients who underwent neuropsychological assessment in previous studies were invited to a follow‐up examination. Patients were grouped according to the treatment status: Sustained virological response (SVR) after IFN treatment (IFN SVR, n = 14) or after therapy with direct acting antivirals (DAA SVR, n = 28) or ongoing HCV infection (HCV RNA+, n = 11). A group of 33 healthy controls served as reference. Patients completed self‐report questionnaires addressing health‐related quality of life (HRQoL), mood and sleep quality and a neuropsychological test battery including tests of memory and attention (Luria's list of words, PSE test, cancelling “d” test, Word–Figure–Memory Test and computer‐based test battery for the assessment of attention [TAP]). At baseline, all three patient groups had worse fatigue, depression, anxiety and HRQoL scores compared to healthy controls. Longitudinal analysis revealed that fatigue and mood slightly improved in all patient groups over time, while HRQoL improved in SVR patients but not in HCV RNA+ patients. Memory test results improved significantly in all patient groups, irrespective of their virological status. In contrast, the attention test results showed no clear change from baseline to follow‐up. Our data can be considered as a hint that HCV eradication—independent of therapy regimen—does not substantially ameliorate neuropsychiatric symptoms in HCV‐afflicted patients.
Influence of captive breeding environment on the locomotor performance and metabolism of the threatened Alcatraz Snouted Treefrog, Ololygon alcatraz
Authors: Lisboa C. S. , de Carvalho J. E. , de Barros F. C. , da Cruz J. B. , Brasileiro C. A. 
Published: November 2024

AbstractEx situ conservation is a complementary strategy to in situ efforts and is vital for safeguarding endangered species through maintenance and breeding in captivity with potential for reintroductions into natural environments. However, it is crucial to recognize that prolonged captivity can lead to diminished abilities of organisms over generations. Factors linked to the impact of phenotypic plasticity during development, such as restricted movement, may affect organism performance during ex situ conservation efforts, potentially making reintroduction into the wild unfeasible. Consequently, it is imperative to analyze physiological differences between captive‐bred and wild individuals. Therefore, this study investigates how captivity influences locomotor performance, morphology, and metabolic capacities of adults and juveniles of the threatened treefrog Ololygon alcatraz, in comparison to natural populations. We obtained proportional measurements of individuals and assessed their locomotor performance through jumping exercise. We also measured the metabolic capacities of the frogs by examining the activity of enzymes involved in energetic metabolic pathways in their skeletal muscle fibers. We found that wild adult frogs had larger limbs, greater jumping abilities, and a more glycolytic profile, while captive adult frogs had smaller limbs and increased aerobic enzyme activity compared to their wild counterparts. These differences probably arise from phenotypic plasticity in ontogenetic development that differs between captive and natural environments, as juveniles do not show such differences. These results highlight the need for innovative strategies in managing captive O. alcatraz populations, which will aid in their successful translocation to the wild and strengthen ex situ conservation efforts.
Temporal relationships between the red fox and the European badger in a Mediterranean protected area
Authors: Oliveira R. , Lazzeri L. , Mouton R. , Gomez V. , Ferretti F. 
Published: November 2024

AbstractNiche partitioning according to time, space, or resources is the key to interspecific coexistence. Interactions among carnivore species are complex: interference is common, although positive relationships may develop through trophic facilitation. In turn, different behavioral responses to coexistence may be reported, ranging from avoidance to attraction, the outcome of which is highly dependent on the local environmental context. Here, we evaluated the temporal partitioning by analyzing spatiotemporal relationships between the red fox Vulpes vulpes and the European badger Meles meles in a Mediterranean?protected area for three full years, using intensive camera trapping. The two species showed similar temporal activity patterns, with a nocturnal activity and peaks at dawn and dusk. We found a substantial temporal overlap between red fox and badger (Δ > 0.78, on a 0‐1 scale). However, we detected some differences in temporal activity patterns across these species and no evidence of interspecific spatiotemporal avoidance. Previous work provided no evidence supporting spatial avoidance among the study species. Our results suggest a role of temporal partitioning at a finer scale during the night to facilitate interspecific coexistence.
Mothers' and fathers' experiences of breastfeeding and returning to paid work after birth: A mixed‐method study
Authors: Ayton Jennifer , Pearson Sue , Graham Alison , Kitsos Gemma , Hansen Emily 
Published: November 2024

AbstractThis mixed‐method study explored the experiences of mothers and fathers combining breastfeeding with returning to paid employment after childbirth. Tasmanian State Service employees participated in an online survey and phone interviews. A total of 130 parents completed the survey, and 42 participated in 60‐min phone interviews. The survey had more female respondents (109) than male (21), and only 4 of the 42 interviews were with fathers. The sample consisted mainly of professional women (84%) and men (16%), predominantly Australian‐born (88%). Two‐thirds of participants worked part‐time (62%), taking either unpaid (52%) or paid leave (61%) within the first 12 months after birth. The majority (88%) preferred to breastfeed, with the mean age of the first formula feed being 4.1 months. A narrative analysis of the qualitative data, informed by work–family conflict theory, reveals that transitioning back to paid work while breastfeeding is challenging for both mothers and fathers. Parents face multiple conflicts between paid work, family responsibilities and maintaining breastfeeding. The emotional and physical demands of feeding, expressing, storing and transporting breast milk, combined with often inadequate workplace facilities, policies and gender discrimination, add to parental pressure. Mothers bear the greatest burden, while fathers’ roles and needs are often overlooked in the workplace. The major finding of this study is that breastfeeding is insufficiently recognised as an integral part of the return‐to‐work process for both parents, generating a form of work–family breastfeeding conflict, where work (part‐time or full‐time) interferes with family responsibilities and breastfeeding. Family‐friendly breastfeeding policies based on equity principles are needed to address workplace gender inequality and discrimination and better support parents in combining work and breastfeeding.
Evolution of Size‐Fecundity Relationship in Medaka Fish From Different Latitudes
Authors: Fujimoto Shingo , Sumarto Bayu K. A. , Murase Iki , Mokodongan Daniel F. , Myosho Taijun , Yagi Mitsuharu , Ansai Satoshi , Kitano Jun , Takeda Satoshi , Yamahira Kazunori 
Published: November 2024

ABSTRACTIn most fishes, the number of offspring increases with maternal body size. Although this size‐fecundity relationship often varies among species as a result of the coevolution of life‐history traits, the genetic basis of such size‐fecundity relationships remains unclear. We explored the genetic basis underlying this size‐fecundity relationship in two small medaka species, Oryzias latipes and O. sakaizumii. Our findings showed that O. sakaizumii has a higher fecundity than O. latipes, and quantitative trait locus analysis using interspecific F2 hybrids showed that chromosome 23 is linked to the size‐fecundity relationship. In particular, the genes igf1 and lep‐b in this region are known to be associated with life‐history traits, including somatic growth, gonad maturation, and progeny numbers in various taxa. Because O. sakaizumii is distributed at higher latitudes and has a shorter spawning season than O. latipes in the wild, we propose that the relatively high fecundity observed in O. sakaizumii is an adaptation to high latitudes. We also discuss the potential ecological ramifications associated with the evolution of increased fecundity in this species.
Non‐pharmacological interventions to support the cognitive rehabilitation of patients admitted to the intensive care unit: An umbrella review
Authors: Holm Anna , Thorn Linette , Alrø Anette Bjerregaard , Nedergaard Helene Korvenius , Jensen Hanne Irene , Dreyer Pia 
Published: November 2024

AbstractBackgroundCritically ill patients experience cognitive impairment throughout their intensive care unit trajectory, in the acute phase and the long‐term alike. Cognitive impairment may negatively impact patients' quality of life and rehabilitation outcomes.AimTo provide an overall examination of literature concerning non‐pharmacological interventions that can enhance cognitive functioning in critically ill patients or facilitate their rehabilitation pathway during and after their intensive care unit stay.Study DesignThis study was conducted as an umbrella review. A systematic search was conducted in CINAHL, Embase, PubMed and PsychINFO, including all types of peer‐reviewed research syntheses published between 2008 and 2023. Eligible studies had to describe interventions capable of improving adult patients' cognitive functioning or supporting their cognitive rehabilitation process throughout the intensive care unit trajectory. All eligible research syntheses were screened systematically; those included were critically appraised.ResultBased on 13 research syntheses, this review summarizes rehabilitative interventions that may be delivered during different phases of critical illness and recovery, in relation to content, delivery and timing. Interventions were: (1) cognitive activities and training, (2) mobilization and physical exercises, (3) emotional, psychological and social support and (4) information.ConclusionDue to limited evidence, no definitive conclusion can be drawn about which type of intervention is most supportive or effective. Additionally, no recommendations can be made about the optimal timing for intervention delivery.Relevance to Clinical PracticeClinicians involved in developing and implementing cognitive rehabilitation measures should consider designing individualized, multicomponent interventions with a focus on content, delivery and timing.
Asymmetric genome merging leads to gene expression novelty through nucleo‐cytoplasmic disruptions and transcriptomic shock in Chlamydomonas triploids
Authors: Prost‐Boxoen Lucas , Bafort Quinten , Van de Vloet Antoine , Almeida‐Silva Fabricio , Paing Yunn Thet , Casteleyn Griet , D'hondt Sofie , De Clerck Olivier , Van de Peer Yves 
Published: November 2024

Summary
Genome merging is a common phenomenon causing a wide range of consequences on phenotype, adaptation, and gene expression, yet its broader implications are not well‐understood. Two consequences of genome merging on gene expression remain particularly poorly understood: dosage effects and evolution of expression.
We employed Chlamydomonas reinhardtii as a model to investigate the effects of asymmetric genome merging by crossing a diploid with a haploid strain to create a novel triploid line. Five independent clonal lineages derived from this triploid line were evolved for 425 asexual generations in a laboratory natural selection experiment.
Utilizing fitness assays, flow cytometry, and RNA‐Seq, we assessed the immediate consequences of genome merging and subsequent evolution. Our findings reveal substantial alterations in genome size, gene expression, protein homeostasis, and cytonuclear stoichiometry. Gene expression exhibited expression‐level dominance and transgressivity (i.e. expression level higher or lower than either parent). Ongoing expression‐level dominance and a pattern of ‘functional dominance’ from the haploid parent was observed.
Despite major genomic and nucleo‐cytoplasmic disruptions, enhanced fitness was detected in the triploid strain. By comparing gene expression across generations, our results indicate that proteostasis restoration is a critical component of rapid adaptation following genome merging in Chlamydomonas reinhardtii and possibly other systems.
Role of Nasopharyngeal Airway in Management of Craniofacial Syndrome‐Associated Upper Airway Obstruction in Children
Authors: Thambar Samara , Wong Matthew D. , Schilling Sandra , Kapur Nitin 
Published: November 2024

ABSTRACTIntroductionUpper airway obstruction (UAO) management in children, particularly those with associated anatomical mid‐face structural differences, poses a significant challenge. This study describes using a nasopharyngeal airway (NPA) in managing infants with severe upper airway obstruction.MethodsInfants discharged home from Queensland Children's Hospital with an NPA in situ for the management of upper airway obstruction were retrospectively evaluated for clinical and demographic parameters, underlying diagnoses and respiratory support, including NPA insertion details and comorbidities.ResultsSixty‐seven children (24 male) were included with a median age at NPA insertion of 24 (IQR 7‐59) days and a median duration of NPA use of 229.1 (IQR 151.50‐297.75) days. Fifty‐two (77.6%) had Pierre Robin sequence. Other diagnoses included CHARGE syndrome, Treacher Collins syndrome, Stickler syndrome, Crouzon syndrome, Bohring–Opitz syndrome, isolated cleft palate, Beckwith–Wiedemann syndrome, Chromosome 3 deletion and VACTERL association. Four infants required tracheostomy, and no complications related to NPA use were reported. Those with oximetry and polysomnography data showed improving indices following NPA insertion [pre NPA median (IQR) SpO2: 95.9% (94.73–97.73), AHI: 51.40 (44.50‐69.45), OAHI 65.9 (56.45‐73.35) and TcCO2 (mmHg) 65.70 (61.95‐67.30) vs. post‐NPA median (IQR) SpO2: 97.1% (96.19–97.9), AHI: 12.20 (11.25‐24.35), OAHI 10.20 (6.12‐5.62) and TcCO2 (mmHg) 52.40 (47.90‐58.40)].ConclusionOur findings highlight the effectiveness and safety of NPA as a noninvasive management option for severe upper airway obstruction in children, particularly in those with anatomical midface structural differences. Further research and larger studies are warranted to confirm these findings and optimise management strategies for these patients.
De Se Modal Illusions
Authors: Weber Clas 
Published: November 2024

AbstractResearch on personal identity often relies on imaginary cases and tends to theorize about our nature from the first‐person perspective. In this paper, I argue that a problem arises when we combine the two methods and assess imaginary cases from the first‐person perspective. The problem is that the link between de se imagination and modality is broken. De se imagination regularly gives rise to de se modal illusions. De se modal illusions come in two varieties: there are de se illusions of possibility and de se illusions of impossibility. I present a systematic account of the two types of illusion. I further make the case that the proposed account is compatible with maintaining a general link between imaginability and possibility. I apply the account to two concrete cases and use it to undercut the motivation behind a central theory of personal ontology, Dualism, and a central account of personal persistence, Lockeanism.
A Computer Vision‐Based Methodology to Estimate Fruit Colour Diversity in Ornamental Pepper (Capsicum spp.)
Authors: Santos Marcos Bruno da Costa , Melo Raylson de Sá , Sousa Victor Eduardo de Carvalho , Medeiros Artur Mendes , Pessoa Angela Maria dos Santos , Silva Silvokleio da Costa , do Nascimento Antonia Maiara Marques , Barroso Priscila Alves 
Published: November 2024

ABSTRACTFruit colour diversity within different ripening stages confers ornamental value for pepper plants. Using images can be helpful in analysing the fruit colour‐related genetic diversity and enable selecting accessions for ornamental purposes by avoiding subjectiveness. This study aimed to evaluate the phenotypic diversity among accessions of ornamental pepper using image processing techniques to identify fruit colours. Photos from 40 fruits from each of 12 accessions were captured by a camera from a smartphone. Separate channels and colour indices were extracted from the images to analyse the accessions using both dendrogram and principal components analysis. Dendrogram analysis allowed separating accessions with predominance of dark fruits from those whose fruits showed lighter and more vivid colours, with a cophenetic correlation coefficient of 0.811. The VARI and NGRDI vegetation indices were efficient in discriminating fruits with a predominance of green colour, and the BGI could be used to discriminate accessions with predominantly reddish‐brown fruits. The proposed method can be used in small‐scale breeding programs for accurately assessing the development of varieties regarding their fruit colour diversity.
Hyperkeratosis in Skin Dimples in Children With Down Syndrome
Authors: Giraldi Susana , Werner Betina , Pasa Morgan Mariana Aparecida , Torrelo Antonio 
Published: November 2024

ABSTRACTDown syndrome (DS) is a common chromosomal disorder with distinct phenotypes and skin markers. This study reports 39 DS patients, aged 1–44  months, who presented from birth with rough, brownish skin in the dimples of their knees and/or elbows. Dermoscopy revealed hyperkeratosis with brownish scales, and biopsies in six cases showed papillomatosis and mild hyperkeratosis. In the cases followed, the condition resolved spontaneously. Hyperkeratosis in the skin dimples on the knees and elbows seems to be a congenital and perhaps characteristic finding in patients with DS.
Identification of novel inhibitors of plant GH3 IAA‐amido synthetases through molecular docking studies
Authors: Luque Adrián , Blanes‐Mira Clara , Caballero Lara , Martínez‐Melgarejo Purificación Andrea , Nicolás‐Albujer Miriam , Pérez‐Alfocea Francisco , Fernández‐Ballester Gregorio , Pérez‐Pérez José Manuel 
Published: November 2024

AbstractAuxins play a critical role in several plant developmental processes and their endogenous levels are regulated at multiple levels. The enzymes of the GRETCHEN HAGEN 3 (GH3) protein family catalyze the conjugation of amino acids to indoleacetic acid (IAA), the major endogenous auxin. The GH3 proteins are encoded by multiple redundant genes in plant genomes, making it difficult to perform functional genetic studies to understand their role in auxin homeostasis. To address these challenges, we used a chemical approach that exploits the reaction mechanism of GH3 proteins to identify small molecule inhibitors of their activity from a defined chemical library. The study evaluated receptor‐ligand complexes based on their binding energy and classified them accordingly. Docking algorithms were used to correct any deviations, resulting in a list of the most important inhibitory compounds for selected GH3 enzymes based on a normalized sum of energy. The study presents atomic details of protein‐ligand interactions and quantifies the effect of several of the identified small molecule inhibitors on auxin‐mediated root growth processes in Arabidopsis thaliana. The direct effect of these compounds on endogenous auxin levels was measured using appropriate auxin sensors and endogenous hormone measurements. Our study has identified novel compounds of the flavonoid biosynthetic pathway that are effective inhibitors of GH3 enzyme‐mediated IAA conjugation. These compounds play a versatile role in hormone‐regulated plant development and have potential applications in both basic research and agriculture.
Patterns of adaptation to stress cardiovascular responses in smokers during ad libitum smoking and withdrawal
Authors: Keogh Tracey M , Howard Siobhán , Nakajima Motohiro , al'Absi Mustafa 
Published: November 2024

AbstractThere is considerable evidence documenting associations between tobacco smoking, including initiation, maintenance, and relapse of addiction, with diminished cardiovascular responses to acute psychological stress. However, less is known about how smokers respond to repeated stress across time. The current study examined patterns of cardiovascular reactivity and adaptation to recurrent stress among 24‐h abstinence smokers, smokers who continued to smoke at their normal rate, and non‐smokers. Smokers were randomly assigned to one of two groups; ad libitum (n = 42), or 24 h abstinence (n = 61); non‐smokers (n = 43) provided comparative referencing. Across the two laboratory sessions, participants (n = 149) were asked to complete a modified version of the trier social stress test, while monitoring systolic and diastolic blood pressure, and heart rate activity. Results showed that while non‐smokers had elevated cardiovascular reactivity to begin with, they showed a greater capacity to habituate to recurrent stress across sessions. The data also suggest that smokers displayed lower cardiovascular reactivity to acute psychological stress and showed little habituation to repeated stress. In adjusted models, smokers exhibited less systolic blood pressure habituation to stress. This response profile in smokers may be a potential mechanism that leads to further cardiotoxic effects on health.