bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical developments of 2017: a review of the literature from selected topics in transfusion. A committee report from the AABB Clinical Transfusion Medicine Committee
Authors: Cushing Melissa M. , Kelley James , Klapper Ellen , Friedman David F. , Goel Ruchika , Heddle Nancy M. , Hopkins Courtney K. , Karp Julie Katz , Pagano Monica B. , Perumbeti Ajay , Ramsey Glenn , Roback John D. , Schwartz Joseph , Shaz Beth H. , Spinella Philip C. , Cohn Claudia S. , Cohn Claudia S. , Cushing Melissa M. , Kelley James , Klapper Ellen 
Published: March 2018

BACKGROUNDThe AABB compiles an annual synopsis of the published literature covering important developments in the field of Transfusion Medicine. For the first time, an abridged version of this work is being made available in TRANSFUSION, with the full‐length report available as an Appendix S1 (available as supporting information in the online version of this paper).STUDY DESIGN AND METHODSPapers published in 2016 and early 2017 are included, as well as earlier papers cited for background. Although this synopsis is comprehensive, it is not exhaustive, and some papers may have been excluded or missed.RESULTSThe following topics are covered: duration of red blood cell storage and clinical outcomes, blood donor characteristics and patient outcomes, reversal of bleeding in hemophilia and for patients on direct oral anticoagulants, transfusion approach to hemorrhagic shock, pathogen inactivation, pediatric transfusion medicine, therapeutic apheresis, and extracorporeal support.CONCLUSIONThis synopsis may be a useful educational tool.
Disparities in detection of antibodies against hepatitis E virus in US blood donor samples using commercial assays
Authors: Zafrullah Mohammad , Zhang Xiugen , Tran Coleen , Nguyen Megan , Kamili Saleem , Purdy Michael A. , Stramer Susan L. 
Published: March 2018

BACKGROUNDReported hepatitis E virus (HEV) antibody assay performance characteristics are variable. Using a subset of surplus US blood donation samples, we compared assays for detecting anti‐HEV immunoglobulin M (Ig)M and IgG or total anti‐HEV antibodies.STUDY DESIGN AND METHODSSamples from 5040 random blood donations, all HEV‐RNA negative, collected primarily in the midwestern United States in 2015 were tested for anti‐HEV IgM and IgG or total anti‐HEV using assays manufactured by Diagnostic Systems, Wantai, and MP Biomedicals.RESULTSOverall, the percentage of detection for anti‐HEV IgG and total anti‐HEV was 11.4%, and for anti‐HEV IgM was 1.8%. Nine samples were reactive for anti‐HEV IgM by all assays, giving a recent infection rate of 0.18%. Anti‐HEV IgG/total anti‐HEV detection rates increased with age. Interassay agreement was higher among the IgG anti‐HEV/total anti‐HEV assays (84%) than the IgM assays (22%). Regression analyses of signal‐to‐cutoff ratios from IgG/total antibody assay were heteroskedastic, indicating no constant variance among these assays, suggesting they may detect different epitopes or were affected by waning or less avid antibodies in the US donor population.CONCLUSIONSAlthough similar percentages of IgG anti‐HEV/total anti‐HEV detection were observed across the three commercial assays, each assay detected a unique sample subpopulation and was heteroskedastic when compared pairwise. Discordance was higher among anti‐HEV IgM assays, but a recent HEV infection rate of at least 0.18% was estimated based on assay concordance.
Anti‐dumping use and its effect on trade liberalisation. Evidence for the European Union
Authors: Ketterer Tobias D. 
Published: March 2018

AbstractIn this paper, we examine the hypothesis that anti‐dumping actions may contribute to trade liberalisation by serving as a “safety valve” for protection‐seeking pressures. Using microlevel trade and tariff data at theHS8‐digit level for the European Union, we investigate whether the use of anti‐dumping measures has acted as a catalyst in subsequent multilateral tariff negotiations. Our findings suggest that anti‐dumping policies may have reduced the resistance of domestic protectionist forces towards major tariff reforms, as they show significantly larger tariff cuts for products previously involved in an anti‐dumping investigation.
Consensus recommendations on standardized magnetic resonance imaging protocols for multicenter canine brain tumor clinical trials
Authors: Packer Rebecca A. , Rossmeisl John H. , Kent Michael S. , Griffin John F. , Mazcko Christina , LeBlanc Amy K. 
Published: March 2018

AbstractThe National Cancer Institute Comparative Brain Tumor Consortium, Patient Outcomes Working Group, propose a consensus document in support of standardized magnetic resonance imaging protocols for canine brain tumor clinical trials. The intent of this manuscript is to address the widely acknowledged need to ensure canine brain tumor imaging protocols are relevant and have sufficient equivalency to translate to human studies such that: (1) multi‐institutional studies can be performed with minimal inter‐institutional variation, and (2) imaging protocols are consistent with human consensus recommendations to permit reliable translation of imaging data to human clinical trials. Consensus recommendations include pre‐ and postcontrast three‐dimensional T1‐weighted images, T2‐weighted turbo spin echo in all three planes, T2*‐weighted gradient recalled echo, T2‐weighted fluid attenuated inversion recovery, and diffusion weighted imaging/diffusion tensor imaging in transverse plane; field of view of ≤150 mm; slice thickness of ≤2 mm, matrix ≥ 256 for two‐dimensional images, and 150 or 256 for three‐dimensional images.
Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa
Authors: Juarez Paulo , Broutin Isabelle , Bordi Christophe , Plésiat Patrick , Llanes Catherine 
Published: March 2018

ABSTRACT

When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of
Pseudomonas aeruginosa
to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene
mexT
result in oligomerization of the LysR regulator MexT, constitutive upregulation of the efflux pump, and increased resistance in clinical isolates.
Effects of Electroacupuncture Combined with Stem Cell Transplantation on Anal Sphincter Injury-Induced Faecal Incontinence in a Rat Model
Authors: Li Xiaojia , Guo Xiutian , Jin Weiqi , Lu Jingen 
Published: March 2018

Background Bone marrow mesenchymal stem cells (BMSCs) and acupuncture are known to mitigate tissue damage. This study aimed to investigate the therapeutic effects of combined electroacupuncture (EA) stimulation and BMSC injection in a rat model of anal sphincter injury-induced faecal incontinence (FI). Methods 60 Sprague-Dawley rats were randomly divided into five groups: sham-operated control, FI, FI+EA, FI+BMSC, and FI+BMSC+EA. The anorectal tissues were collected on days 1, 3, 7 and 14. Repair of the injured anal sphincter was compared using haematoxylin and eosin (HE) and immunocytochemiscal analyses with sarcomeric α actinin. The expression of stromal cell derived factor-1 (SDF-1) and monocyte chemoattractant protein-3 (MCP-3) was detected by quantitative reverse transcription PCR to evaluate the effects of EA on the homing of BMSCs. Results The therapeutic effect of combined EA+BMSCs on damaged tissue was the strongest among all the groups as indicated by HE and immunohistochemical staining. The expression of SDF-1 and MCP-3 was significantly increased by combined EA and BMSC treatment when compared with the other groups (P=0.01 to P<0.05), suggesting promotive effects of EA on the homing of BMSCs. Conclusion The combination of EA and BMSC transplantation effectively repaired the impaired anal sphincters. The underlying mechanism might be associated with apparent promotive effects of EA on the homing of BMSCs. Our study provides a theoretical basis for the development of a non-surgical treatment method for FI secondary to muscle impairment.
Perspectives of healthcare providers on the nutritional management of patients on haemodialysis in Australia: an interview study
Authors: Stevenson Jessica , Tong Allison , Campbell Katrina L , Craig Jonathan C , Lee Vincent W 
Published: March 2018

ObjectiveTo describe the perspectives of healthcare providers on the nutritional management of patients on haemodialysis, which may inform strategies for improving patient-centred nutritional care.DesignFace-to-face semistructured interviews were conducted until data saturation, and thematic analysis based on principles of grounded theory.Setting21 haemodialysis centres across Australia.Participants42 haemodialysis clinicians (nephrologists and nephrology trainees (15), nurses (12) and dietitians (15)) were purposively sampled to obtain a range of demographic characteristics and clinical experiences.ResultsSix themes were identified: responding to changing clinical status (individualising strategies to patient needs, prioritising acute events, adapting guidelines), integrating patient circumstances (assimilating life priorities, access and affordability), delineating specialty roles in collaborative structures (shared and cohesive care, pivotal role of dietary expertise, facilitating access to nutritional care, perpetuating conflicting advice and patient confusion, devaluing nutritional specialty), empowerment for behaviour change (enabling comprehension of complexities, building autonomy and ownership, developing self-efficacy through engagement, tailoring self-management strategies), initiating and sustaining motivation (encountering motivational hurdles, empathy for confronting life changes, fostering non-judgemental relationships, emphasising symptomatic and tangible benefits, harnessing support networks), and organisational and staffing barriers (staffing shortfalls, readdressing system inefficiencies).ConclusionsOrganisational support with collaborative multidisciplinary teams and individualised patient care were seen as necessary for developing positive patient–clinician relationships, delivering consistent nutrition advice, and building and sustaining patient motivation to enable change in dietary behaviour. Improving service delivery and developing and delivering targeted, multifaceted self-management interventions may enhance current nutritional management of patients on haemodialysis.
Identifying priority policy issues and health system research questions associated with recovery outcomes for burns survivors in India: a qualitative inquiry
Authors: Jagnoor Jagnoor , Bekker Sheree , Chamania Shobha , Potokar Tom , Ivers Rebecca 
Published: March 2018

ObjectivesThis study aimed to identify priority policy issues and health system research questions associated with recovery outcomes for burns survivors in India.DesignQualitative inquiry; data were collected through semistructured in-depth interviews and focus group discussions.SettingNine sites in urban and rural settings across India, through primary, secondary and tertiary health facilities.ParticipantsHealthcare providers, key informants, burns survivors and/or their carers.ResultsParticipants acknowledged the challenges of burns care and recovery, and identified the need for prolonged rehabilitation. Challenges identified included poor communication between healthcare providers and survivors, limited rehabilitation services, difficulties with transportation to health facility and high cost associated with burns care. Burns survivors and healthcare providers identified the stigma attached with burns as the biggest challenge within the healthcare system, as well as in the community. Systems barriers (eg, limited infrastructure and human resources), lack of economic and social support, and poor understanding of recovery and rehabilitation were identified as major barriers to recovery.ConclusionsThough further research is needed for addressing gaps in data, strengthening of health systems can enable providers to address issues such as developing/providing, protocols, capacity building, effective coordination between key organisations and referral networks.
How do orthopaedic surgeons and rehabilitation professionals interpret and assess ‘toe touch’ weight bearing and ‘partial’ weight bearing status in the rehabilitation setting?
Authors: Thompson Stephen G , Phillip Rhodri D , Roberts Andrew 
Published: March 2018

AimTo compare the interpretation of toe touch weight bearing (TTWB) and partial weight bearing (PWB) among orthopaedic surgeons, rehabilitation professionals and patients.Methodology78 consultant and middle-grade orthopaedic surgeons in the UK completed a questionnaire. 64 rehabilitation professionals (including physiotherapists) at Defence Medical Rehabilitation Centre Headley Court were also recruited. Both groups provided their interpretation of TTWB and PWB as a percentage of total body weight (%TBW). Each rehabilitation professional, then applied what they interpreted to be TTWB and PWB using a Lasar Posture weighing device. The predicted values were compared with the actual values demonstrated.ResultsThere was no significant difference between orthopaedic surgeons and rehabilitation professionals in their interpretation of TTWB and PWB, however there was a wide range of responses. There was a significant difference between the predicted %TBW and the actual values demonstrated by the ‘educated patient’ (mean difference 4.8 (TTWB) and 22.9 (PWB)).ConclusionHealthcare professionals vary greatly in their interpretation of the terms TTWB and PWB. Therefore, for a consistency in rehabilitation delivery the terms should not be used in isolation without a further descriptor. Static measures of weight application are lower than people think they are applying. We encourage the use of loading practice with a scale to reassure and educate patients.
Self-perceived risk of STIs in a population-based study of Scandinavian women
Authors: Guleria Sonia , Faber Mette Tuxen , Hansen Bo T , Arnheim-Dahlström Lisen , Liaw Kai-Li , Munk Christian , Nygård Mari , Kjær Susanne Krüger 
Published: March 2018

ObjectiveThis study examined the associations between current behaviours/characteristics and self-perceived risk for STIs, among randomly selected women aged 18–45 years from Denmark, Norway and Sweden.MethodA population-based, cross-sectional, questionnaire study (paper based, web based and telephone based) was conducted during 2011–2012. We compared medium–high STI risk perception with no/low risk perception. The associations were explored for women who had ever had sexual intercourse and for women with a new partner in the last 6 months using multivariable logistic regression.ResultThe overall prevalence of medium–high STI risk perception was 7.4%. It was highest among women aged 18–24 years (16.2%) and among the Danish women (8.8%). Number of new sexual partners in the last 6 months (≥3vs 0 partners, OR 14.94, 95% CI 13.20 to 16.94) was strongly associated with medium–high STI risk perception. Among women with a new partner in the last 6 months, lack of condom use increased medium–high STI risk perception (OR 1.73, 95% CI 1.52 to 1.96). Genital warts in the last year, binge drinking and being single were associated with increased risk perception and remained statistically significant after additional adjustments were made for number of new partners and condom use with new partners in the last 6 months.ConclusionSubjective perception of risk for STI was associated with women’s current risk-taking behaviours, indicating women generally are able to assess their risks for STIs. However, a considerable proportion of women with multiple new partners in the last 6 months and no condom use still considered themselves at no/low risk for STI.
Scalable Path-Setup Scheme for All-Optical Dynamic Circuit Switched NoCs in Cache Coherent CMPs
Authors: Grani Paolo , Bartolini Sandro 
Published: March 2018

Nanophotonics is a promising solution for on-chip interconnection due to its intrinsic low-latency and low-power features, which can be useful for performance and energy in future Chip Multi-Processors (CMPs).
This article proposes a novel arbitrated all-optical path-setup scheme for tiled CMPs adopting circuit-switched optical networks. It aims at significantly reducing path-setup latency and overall energy consumption. The proposed arbitrated scheme is able to configure multiple photonic switches simultaneously, instead of sequentially as it is done in state-of-the-art proposals. The proposed fast optical path-setup solution reduces the overhead in each transmission and, most importantly, allows optical circuit-switched networks to effectively serve cache coherence traffic, which is mainly composed of relatively small messages.
Specifically, we propose a single-arbiter scheme where the whole topology is managed by a central module (single-arbiter) that takes care of the path-setup procedures. Then, to tackle scalability, we propose a logically clustered architecture (multi-arbiter) in which an arbiter is allocated in each logical core-cluster and an ad hoc distributed reservation protocol coordinates arbiters to manage inter-cluster path reservations.
We show that our proposed single-arbiter architecture outperforms a state-of-the-art optical network with sequential path-setup (optical baseline) in the case of 8- and 16-core tiled CMP setups. However, due to serialization issues, the single-arbiter solution is not able to compete with a reference electronic baseline for bigger 32- and 64-core setups even if still performing much better than the optical baseline. Conversely, our multi-arbiter hierarchical solution allows us to improve performance up to almost 20% and 40% for 32- and 64-core setups, respectively, demonstrating a wide applicability of the proposed technique.
Energy-wise, the analyzed solutions enable significant savings compared to both the optical baseline with sequential path setup, and to the electronic counterpart. Specifically, results show more than 25% average improvement for the single-arbiter in the 8- and 16-core cases, and more than 40% and 15% savings for the multi-arbiter in the 32- and 64-core cases, respectively.
Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling
Authors: Terra Mariana , Oberkampf Marine , Fayolle Catherine , Rosenbaum Pierre , Guillerey Camille , Dadaglio Gilles , Leclerc Claude 
Published: March 2018

Abstract
A growing number of observations has suggested that plasmacytoid dendritic cells (pDC) play a critical role in tumor biology. In patients, infiltration of tumors by pDCs generally correlates with a poor prognosis, suggesting that pDCs may play an important role in the host–tumor relationship. Here, we analyze the influence of pDCs in solid tumor development using two different tumor models: TC-1 and B16-OVA. Phenotypic and functional gene profiling analysis of tumor-associated pDCs showed that the tumor microenvironment affected their activation status and ability to produce cytokines and chemokines. In addition, tumor cells secreted factors that inhibit the ability of pDCs to produce type I IFN. Among the various cytokines and chemokines produced by the tumor cells, we demonstrate that TGFβ is the main factor responsible for this inhibition. Using a mouse model deficient for pDCs, we also show that pDCs promote TC-1 tumor growth and that natural killer (NK) cells and regulatory T cells are involved in the protumoral effect of pDCs. Overall, our results evidence the cross-talk among pDCs, NK, and regulatory T cells in the promotion of tumor growth and their role in the development of antitumor immune responses.
Significance: These findings highlight the importance of pDCs in the cross-talk between tumor cells and the immune system. Cancer Res; 78(11); 3014–26. ©2018 AACR.
The Employment Status of Ministers: A Judicial Retcon?
Authors: Sandberg Russell 
Published: March 2018

Abstract
“Retroactive continuity”, often abbreviated as “retcon”, is a term often used in literary criticism and particularly in relation to science fiction to describe the altering of a previously established historical continuity within a fictional work. To date, however, the concept has not been used in relation to law. Legal judgments often refer to history and include historical accounts of how the law has developed. Such judgments invariably include judicial interpretations of history. On occasions, they may even include a “retconned” interpretation of legal history – a “judicial retcon” – that misrepresents the past and rewrites history to fit the “story” of the law that the judge wants to give. This article explores the usefulness of a concept of a “judicial retcon” by means of a detailed case study concerning whether ministers of religion are employees.
Les anglicismes de Beckett à l’ époque de la “French frenzy”
Authors: Germoni Karine 
Published: March 2018

Résumé
Les ébauches et pré-originales des nouvelles “L’ Expulsé” et “La Fin”, écrites en français par Beckett en 1946, alors qu’ il choisit le français comme langue d’ écriture, montrent que malgré sa possession excellente du français, échappent encore çà et là à l’ Irlandais des anglicismes, y compris au niveau des connecteurs logiques et des signes de ponctuation, la virgule “anglaise” pour l’ essentiel. Cet essai montre comment les signes de ponctuation témoignent des traces que l’ anglais laisse dans le français de Beckett dans les textes des premières années.
Le bilinguisme comme genèse du projet beckettien
Authors: Louar Nadia 
Published: March 2018

Résumé
Cet essai veut s’ inscrire dans la perspective d’ un ‘devenir de la critique génétique’ qui dépasserait les frontières de l’ écrit. Il propose ainsi d’ adapter les méthodes herméneutiques et objets scientifiques de cette critique pour rendre compte du processus de création à l’ origine de l’ Œuvre bilingue beckettienne. Dans ce but, il repère dans la structure de l’ écriture bilingue la trace d’ un travail mental qui permet de reconstituer une ‘genèse du commencement.’ Cette reconstitution se fonde sur une analyse génétique hétérodoxe conduite à partir de la rémanence de l’ activité créatrice.
Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma
Authors: Otsuki Takahiko , Nakashima Taku , Hamada Hironobu , Takayama Yusuke , Akita Shin , Masuda Takeshi , Horimasu Yasushi , Miyamoto Shintaro , Iwamoto Hiroshi , Fujitaka Kazunori , Miyata Yoshihiro , Miyake Masayuki , Kohno Nobuoki , Okada Morihito , Hattori Noboru 
Published: March 2018

Angiogenesis is a crucial factor in the progression of malignant pleural mesothelioma (MPM) and antiangiogenic strategies might be effective against MPM. Aminopeptidase N (APN)/CD13 promotes tumour angiogenesis and is associated with poor prognosis; however, its clinical significance in MPM remains unclear.In 37 consecutive patients with surgically resected MPM, we evaluated the association between immunohistochemical APN/CD13 expression in resected tumours and survival. Additionally, the antitumour and antiangiogenic effects of MT95-4, a fully humanised anti-APN/CD13 monoclonal antibody, were evaluated in mice orthotopically implanted with EHMES-10 (abundantly expressing APN/CD13) and MSTO-211H (scarcely expressing APN/CD13) MPM cells.High tumour APN/CD13 expression was associated with poor prognosis in MPM patients (p=0.04), and MT95-4 treatment reduced tumour growth and angiogenesis in mice harbouring EHMES-10 but not MSTO-211H cells. Furthermore, in mice harbouring EHMES-10 cells, MT95-4 combined with cisplatin more effectively suppressed tumour progression than cisplatin alone.Taken together, these results suggest that APN/CD13 is implicated in the aggressiveness of MPM. Here, MT95-4 treatment reduced tumour progression likely by inhibiting angiogenesis, suggesting APN/CD13 as a potential molecular target for MPM treatment. Additionally, combination treatment with MT95-4 and cisplatin could represent a promising approach to treating MPM exhibiting high APN/CD13 expression.