bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Older Age and Comorbidity on Locoregional and Distant Breast Cancer Recurrence: A Large Population-Based Study
Authors: de Boer Anna Z. , van der Hulst Heleen C. , de Glas Nienke A. , Marang-van de Mheen Perla J. , Siesling Sabine , de Munck Linda , de Ligt Kelly M. , Portielje Johanneke E. A. , Bastiaannet Esther , Liefers Gerrit Jan 
Published: September 2019

Abstract

Background
Studies have demonstrated worse breast cancer-specific mortality with older age, despite an increasing risk of dying from other causes due to comorbidity (competing mortality). However, findings on the association between older age and recurrence risk are inconsistent. The aim of this study was to assess incidences of locoregional and distant recurrence by age, taking competing mortality into account.

Materials and Methods
Patients surgically treated for nonmetastasized breast cancer between 2003 and 2009 were selected from The Netherlands Cancer Registry. Cumulative incidences of recurrence were calculated considering death without distant recurrence as competing event. Fine and Gray analyses were performed to characterize the impact of age (70–74 [reference group], 75–79, and ≥80 years) on recurrence risk.

Results
A total of 18,419 patients were included. Nine-year cumulative incidences of locoregional recurrence were 2.5%, 3.1%, and 2.9% in patients aged 70–74, 75–79, and ≥80 years, and 9-year cumulative incidences of distant recurrence were 10.9%, 15.9%, and 12.7%, respectively. After adjustment for tumor and treatment characteristics, age was not associated with locoregional recurrence risk. For distant recurrence, patients aged 75–79 years remained at higher risk after adjustment for tumor and treatment characteristics (75–79 years subdistribution hazard ratio [sHR], 1.25; 95% confidence interval [CI], 1.11–1.41; ≥80 years sHR, 1.03; 95% CI, 0.91–1.17).

Conclusion
Patients aged 75–79 years had a higher risk of distant recurrence than patients aged 70–74 years, despite the higher competing mortality. Individualizing treatment by using prediction tools that include competing mortality could improve outcome for older patients with breast cancer.
Synthesis of organic-inorganic hybrid nanoflowers using Trigonella foenum-graecum seed extract and investigation of their anti-microbial activity
Authors: ALTINKAYNAK Cevahir , ILDIZ Nilay , BALDEMİR Ayşe , ÖZDEMİR Nalan , YILMAZ Vedat , ÖÇSOY İsmail 
Published: September 2019

Herein
we report a green method for the synthesis of organic-inorganic hybrid
nanoflowers using a Trigonella
foenum-graecum L. (TF) (Fenugreek seeds) extracts as an organic part and
copper ions acting as an inorganic part. The organic-inorganic hybrid
nanoflowers using TF seed extract (TF-Cu2+ hNFs) were characterized
by SEM, XRD, EDX and FTIR. The morphology of the TF-Cu2+ hNFs was
quite spherical and monodisperse with ∼18μm size. The TF-Cu2+
hNF exhibited the effective anti-bacterial activity against Enterococcus
faecium, Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus,
Salmonella typhi and Escherichia coli at 1-10 µg ml-1
concentrations except against Pseudomonas aeruginosa and Haemophilus
influenza. However, both TF-Cu2+ hNFs and free TF extracts
showed any antifungal activities against Candida albicans or Candida
glabrata. The study revealed that TF-Cu2+ hNFs could be used as
a therapeutic agent for microbial infections and has the potential to overcome
drug resistance.
Çocuklardaki çölyak hastalığının annelerin yaşam kalitesi ve depresyon düzeylerine etkisi
Authors: SEVİNÇ Nergiz , ÖZTÜRK Ahmet , SEVİNÇ Eylem 
Published: September 2019

Giriş ve Amaç: Çölyak hastalığı olan çocukların sürekli olarak glutensiz diyete uyma zorunluluğu çocukla birlikte ailesine de psikososyal bir yük getirmekte ve özellikle çocuğun birincil bakımından sorumlu annelerin yaşam kalitesini ve psikososyal durumlarını olumsuz etkileyebilmektedir. Bu çalışmada çölyak hastalığı olan çocukların annelerinin, kontrol grubundaki çocukların anneleri ile karşılaştırılarak, yaşam kalitesinin ve depresyon düzeylerinin incelenmesi amaçlanmıştır.Gereç ve Yöntem: Çalışma Erciyes Üniversitesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Gastroenteroloji Polikliniğinde 1 Temmuz-31 Aralık 2015 tarihleri arasında yapılmıştır. Çalışma grubuna; 93 çölyak hastalığı olan çocuğun annesi ile 93 sağlam çocuğun annesi olmak üzere toplam 186 anne alınmıştır. Çalışmaya katılan tüm annelerden sözlü onam alınarak, sosyodemografik veri formu, yaşam kalitesi ölçeği (SF-36) ve Beck Depresyon Ölçeği yüz yüze görüşme tekniği ile uygulanmıştır. Verilerin değerlendirilmesinde SPSS paket programı kullanılmıştır. İstatistiksel analizlerde p&lt;0.05 değerleri anlamlı kabul edilmiştir.Bulgular: Çölyak hastalığı olan çocukların annelerinde kontrol grubundaki çocukların annelerine göre yaşam kalitesi puanları daha düşük bulunmuştur (Sırasıyla genel sağlık (32 ve 44), fiziksel fonksiyonellik (50 ve 80), fiziksel rol güçlüğü (50 ve 100), mental sağlık (48 ve 72), enerji (35 ve 60), emosyonel sağlık (33.33 ve 100), bedensel ağrı (30 ve 70) ve sosyal fonksiyonellik (50 ve 62.50). Özellikle eğitim düzeyi düşük olan, 4 ve üzeri çocuk sahibi olan, ekonomik durumu kötü olan ve herhangi bir işte çalışmayan çölyaklı çocuk annelerinde yaşam kalitesi puanları daha düşük bulunmuştur. Beck Depresyon Ölçeğine göre yapılan değerlendirmelerde de; çölyaklı çocuk annelerinde depresif belirti görülme oranı (%69.9) kontrol grubundaki annelere göre (%14.0) anlamlı derecede yüksek bulunmuştur. Yapılan ileri analizlerde; 41 yaş ve üzerinde olan, 4 ve üzeri çocuk sahibi olan, ekonomik durumu kötü olan ve köy ve kasabalarda yaşayan annelerde depresif belirti oranları daha fazla bulunmuştur. Sonuç: Annelerin, kronik hastalığı olan çocuğu ile uğraşırken yaşam kalitelerinin ve beden-ruh sağlıklarının olumsuz yönde etkilendiği tespit edilmiştir. Çölyak hastalığı olan bir çocuk tespit edildiğinde, annelerinin de yaşam kalitelerinin korunması ya da ruhsal sıkıntılarla karşılaşmalarının önlenmesi açısından takip edilmesinin ve destek olunmasının yararlı olacağı düşünülmektedir.
Cincuenta ediciones, veintiún años de existencia y persistencia en las investigaciones en derecho y ciencias sociales, su divulgación e impacto social
Authors: Matias Camargo Sergio Roberto 
Published: September 2019

La revista Diálogos Saberes, Investigaciones en derecho y ciencias sociales, es la publicación seriada oficial del Centro de Investigaciones Socio Jurídicas de la Facultad de Derecho de la Universidad Libre de Bogotá, Sede Principal. Con el presente número, hemos publicado cincuenta ediciones ininterrumpidamente, en periodos semestrales.
Cumplimos veintiún años de existencia desde el lanzamiento del Número 1 el 25 de febrero de 1998 y catorce de reconocimiento por Colciencias como Revista Nacional Especializada de Carácter Científico e incluida en el Indice Bibliográfico Nacional-Publindex (indexada) en la Categoría C, desde el primer semestre de 2005, hasta el treinta de diciembre de 2019. Actualmente, se encuentra reconocida e incluida en los Servicios de Indexación y Resumen (Sires) con Comités de selección de Latindex (UNAM, México), Ebsco Academic Search Complete, The Left Index, Academic Search Ultimate, Fuente Académica plus y alojada en las bases de datos de Dialnet (Universidad de la Rioja, España).
Technology trends, Education 4.0 and beyond
Authors: Keser Hafize , Semerci Ali 
Published: September 2019

The real-time communication and collaboration of the internet of things, the internet of services and cyber-physical systems with each other and with people has started a new era in industrial production. This era called Industry 4.0, brought about revolutionary changes in many areas of life, including education. In order to fully exploit the potential of smart products, services and business opportunities that are expected to be widely used in all sectors in the near future, education systems need to be overhauled to meet the qualified manpower required by this dynamic process. The ability of companies and institutions with strong information and technology infrastructure to reflect advanced digital technologies to innovation and production processes requires some certain skills, described as 21st century skills. Education 4.0, a reflection of the era of Industry 4.0, refers to a period in which education paradigms, approaches and technologies have been changed. In this study, major technology trends and their reflections on learning and teaching processes are examined within the framework of changing educational paradigms and teaching approaches.

Keywords: Education 4.0, Industry 4.0, ICT in education, technology trends
Proceso Visionario hacia el Desarrollo Biotecnológico
Authors: Arnáez-Serrano Elizabeth , Moreira-González Ileana , Alvarenga-Venutolo Silvana , Abdelnour-Esquivel Ana , Flores-Mora Dora , Rojas-Chaves Miguel 
Published: September 2019

El Centro de Investigación en Biotecnología (CIB), creado en 1994, es la unidad de investigación de la Escuela de Biología del Instituto Tecnológico de Costa Rica. Como ente investigador, el CIB ofrece a la sociedad una serie de servicios técnicos especializados, como producto del conocimiento obtenido a lo largo de una cantidad creciente de proyectos de investigación, que se han desarrollado enfocados en las tres áreas de investigación: Biotecnología Vegetal, Biotecnología Ambiental y Aplicaciones
Biomédicas. Durante los 25 años de su funcionamiento, los investigadores han mostrado un fuerte compromiso para generar ciencia y tecnología con impacto a nivel nacional e internacional. Adicionalmente, las diferentes iniciativas de cooperación entre este centro y otras instituciones son una muestra clara de la dinámica de crecimiento de esta unidad de investigación, tanto en el número de proyectos como en el nivel de los mismos, siendo referente a nivel nacional y regional.
ESTIMATION OF CEPHALOSPORINS (CEFTRIAXONE, CEFTAZIDIME) ANTIBIOTICS AS PURE AND PHARMACEUTIC FORMS BY COLOR PRODUCED REACTION IN UV-VIS SPECTROPHOTOMETIC TECHNIQUE
Authors: Al-Rufaie Mohauman Mohammad Majeed , Motaweq Zahraa Yosif 
Published: September 2019

<em>A new simple, accurate and low cost-effective UV-VIS spectrophotometric methods has been developed for the analysis of chosen cephalosporins (ceftriaxone, ceftazidime) in bulk samples and pharmaceutical dosage forms<strong> </strong>by using a specific color-generated reaction. This method involves the Schiff 's base formation reaction between selected cephalosporins with alcoholic 5-sulfo salicylaldehyde reagent 5SSA with heating to establish a yellow colored product displaying λmax at 426 nm as well as 412 nm sequentially. These methods applied to the Beer’s law through the range of concentration was (4 - 60 µg.ml<sup>-1</sup>), (5 -50µg ml<sup>-1</sup>) respectively for two drugs. The analysis results for these studies have been tested statistically by the studies of recovery. These methods were successfully applied to the determination of the cephalosporins in bulk form and in Pharmaceuticals additionally it was shown that these methods have equivalent accuracy with the common method(BP)estimation procedures for the studied drugs. The interferences from frequently taken excipients were no influence on the estimation process .The study could discover a good as an employment cost-influence and speed method which that possibility used for making quality control for these cephalosporin antibiotics.</em>
From Policy to Practice: Women's Experiences of Breastfeeding-Friendly Worksites, Part 2
Authors: Cheyney Melissa , Henning Margaret , Horan Holly , Bovbjerg Marit L. , Ferguson Maryanne 
Published: September 2019

IntroductionMaintaining lactation after returning to work is imperative for overall breastfeeding success, yet mothers who return to full-time employment outside the home are unlikely to meet their breastfeeding goals. Breastfeeding-friendly worksites are one potential solution.MethodUsing semi-structured interviews with employees in one rural New England town (N = 18), we aimed to better understand the barriers and supports to continued lactation at “breastfeeding-friendly” worksites.ResultsFive key themes emerged from participants' narratives; two built environment-focused themes are discussed here.DiscussionFindings expose the disproportionate burden placed on women when care- and wage-work are combined, even in worksites at least theoretically committed to supporting lactation following a return to work.
Physics-Based Fluid-Flow Modeling of Liquids-Rich Shale Reservoirs Using a 3D Three-Phase Multiporosity Numerical-Simulation Model
Authors: Jimenez Bruno A. , Aguilera Roberto 
Published: September 2019

Summary
Production from liquids–rich shale reservoirs in the US and Canada has increased significantly during the past few years. However, a rigorous understanding of shale rocks and fluid flow through them is still limited and remains a challenge. Thus, the objective of our research is developing a 3D physics–based model for simulating fluid flow through these types of multiporosity rocks. This is important given the recent spread of these types of reservoirs throughout the world.
Simulation of liquids–rich shale reservoirs is performed with the construction of an original fully implicit 3D multiphase modified black–oil finite–difference numerical formulation, which uses a multiporosity approach as well as diffusion from solid kerogen. The multiporosity system includes adsorbed porosity, organic porosity, inorganic porosity, natural–fracture porosity, and hydraulic–fracture porosity. A numerical model is developed with capabilities to handle dissolved gas in the solid part of the organic matter, adsorption/desorption from the organic pore walls, viscous– and non–Darcy–flow mechanisms (slip flow and Knudsen diffusion), and stress–dependent properties of natural and hydraulic fractures.
Examples of simulated results are presented as crossplots of pressure, production rates, and cumulative production vs. time. These plots are used to show the contributions of free gas, adsorbed gas, and dissolved gas to fluid production from liquids–rich shale reservoirs. Results indicate that both desorption and gas diffusion positively affect shale performance. Simulation results demonstrate that not taking into account desorption and diffusion from solid kerogen leads to underestimating production from liquids–rich shale reservoirs. Furthermore, the simulation study shows that long periods of time are required for the effects of these two mechanisms to be manifested. This helps to explain why shales have been produced over long periods of time (several decades), such as in the case of Devonian wells in the Appalachian Basin.
The type of 3D simulation model for multiporosity liquids–rich shale reservoirs developed in this paper is not currently available in the literature. The approach implemented in this paper provides a novel and important foundation for simulating complex shale reservoirs.
Simulation Interpretation of Capillary Pressure and Relative Permeability From Laboratory Waterflooding Experiments in Preferentially Oil-Wet Porous Media
Authors: Andersen Pål Ø. , Walrond Kenny , Nainggolan Citra K. L. , Pulido Eliana Y. , Askarinezhad Reza 
Published: September 2019

SummaryIn preferentially oil-wet porous media, laboratory waterflooding experiments are prone to capillary end effects. The wetting phase (oil) will tend to accumulate at the outlet where the capillary pressure is zero and leave a highly remaining-oil saturation at steady state (defined by a stable pressure drop and a zero oil-production rate) compared to the residual-oil saturation. Andersen et al. (2017c) derived analytical solutions describing how the capillary pressure and relative permeability of water (the injected phase) could be determined on the basis of pressure drop and average saturation at steady states obtained at different water-injection rates. Plotting these values against inverse rate reveals linear trends at high rates, with slopes and intercepts that directly quantify the saturation functions in the range of negative capillary pressures. The method is similar to the Gupta and Maloney (2016) intercept theory but quantifies entire functions rather than a single point and provides the trends also at low rates, thus using all the information.Our aim is to demonstrate how pressure drop and oil production at steady state for different water-injection rates can be used to derive relative permeability and capillary pressure from waterflooding. This is done in three ways. First, synthetic transient waterflooding tests are generated (using a core-scale simulator), applying the same saturation-function correlations as assumed in the analytical solution. Then, more-general correlations are assumed when generating the synthetic data. This is to test the robustness of the analytical solution in producing functions similar to the “true” ones. Finally, we perform a waterflooding experiment in the laboratory on a high-permeability (3 darcies) Bentheimer sandstone core, altered to an oil-wet state. Forced imbibition was started at a rate of 0.4 pore volumes (PV) per day, which was increased stepwise after approaching a steady state. Twelve rates were applied, differing overall by a factor of ≈1,000 to yield states governed by capillary forces and advective forces. The results were interpreted using both full history matching of the transient data and matching of the steady-state data with the analytical solution.The experimental procedure and model demonstrate that only water relative permeability and capillary pressure determine the steady state during waterflooding, and hence can be estimated accurately. The analytical solution could simultaneously match the trends and magnitude of a steady-state pressure drop and production with injection rate to give an estimation of the saturation functions. The estimated saturation functions from the analytical solution agreed well with the estimates from full history matching.
Online-Group Intervention after Suicide Bereavement through the Use of Webinars: Study Protocol for a randomized controlled Trial
Authors: Wagner Birgit , Hofmann Laura , Maaß Ulrike 
Published: September 2019

Abstract
Introduction The death of a significant person through suicide is a very difficult experience and can have long-term impact on an individual’s psychosocial and physical functioning. However, there are only few studies which have examined the effects of interventions in suicide survivors. In the present study, we examined an online-group intervention for people bereaved by suicide using a group-webinar. Methods The intervention was developed based on focus groups with the target group. The cognitive-behavioral 12-module webinar-based group intervention focuses on suicide bereavement related themes such as feelings of guilt, stigmatization, meaning reconstruction and the relationship to the deceased. Further, the webinar includes testimonial videos and psychoeducation. The suicide survivors are randomized to the intervention or the waiting- list in a group cluster randomized controlled trial. Primary outcome were suicidality (BSSI) and depression (BDI-II), secondary outcomes are symptoms of prolonged grief disorder (ICG-D), PTSD (IES-R), stigmatization (STOSASS) and posttraumatic cognitions (PTCI). Discussion Previous studies of internet-based interventions for the bereaved were writing interventions showing large treatment effects. Little is known about the use of webinars as group interventions. Advantages and challenges of this novel approach of psychological interventions will be discussed.
Is sentinel lymph node biopsy alone accurate for breast cancer mastectomy? Results of a cohort study of 2423 patients.
Authors: HOUVENAEGHEL Gilles , Classe J.M. , Blache G. , Mazouni C. , Reyal F. , Gimbergues P. , Daraï E. , Azuar A.S. , Colombo P.E. , Bannier M. , Lambaudie E. , Cohen M. 
Published: September 2019

Abstract
Backgroud : Few patients with mastectomy and only with pN0(i+) or pN1mi sentinel node (SN) were included in randomized trial. To demonstrate SN biopsy accuracy for mastectomy.
Methods: We examined results of SN among a multi-institutional cohort of patients, <=cT2-N0, who required total mastectomy, according to SN status and complementary axillary lymph-node dissection (cALND) or not. We have analyzed involved non-sentinel node (NSN) rate at cALND, overall (OS) and disease-free survival (DFS).
Results: Among 2423 patients we reported 1307 pN0(i-)SN, 120 pN0(i+)SN, 273 pN1miSN and 723 pN1macro-metastases SN with cALND respectively in 24.5, 73.3, 82.4 and 93.1%. Median follow-up was 42.72 months.
Among 320 patients with pN0(i-)SN we observed 35 NSN macro-metastases (10.9%) and among 723 patients with SN macro-metastases, cALND was omitted in 50 patients (6.9%): in multivariate analysis, OS and DFS were not significantly different according to cALND or not.
Among 120 patients with pN0(i+)SN and 273 with pN1miSN, cALND were respectively omitted in 32 and 48 patients: age, pT-size and SN-status were predictive of NSN involvement. In multivariate analysis, post-mastectomy radiotherapy, regional nodal irradiation and adjuvant chemotherapy were significantly correlated to cALND and a significant lesser DFS rate was reported for patients without cALND (HR: 3.861, p=0.002).
Conclusion: SN biopsy appeared as an accurate procedure for axillary staging of breast cancer mastectomy for pN0 SN status. For pN1-macro-metastases it is not possible to propose to avoid cALND. When SN was involved by ITC or micro-metastases, omission of cALND is still controversial and should have a negative prognosis impact in relation with a down staging and under treatment.
Survival and predictors of early neonatal death in neonatal intensive care unit of Mekelle general and Ayder comprehensive specialized hospitals, Northern Ethiopia, 2018: prospective cohort study
Authors: Kahsay Abrehet Hadera , Abebe Haftom Temesgen , Gebretsadik Letekirstos Gebreegziabher , Tekle Tesfay Hailu 
Published: September 2019

Abstract
Background: Early neonatal mortality refers to deaths of neonates between 0 and 6 days of life. This contributes three-quarters of neonatal deaths globally. Its predictors vary by country with the availability and quality of health care, which was chosen as the measure of mortality and remains a global public health concern especially in sub-Saharan African countries, including Ethiopia. So the aim of this study is to determine incidence, median survival time and to identify the predictors of early neonatal mortality.Methods: A prospective cohort study was conducted in Mekelle general and Ayder comprehensive specialized hospitals, Tigray, Ethiopia from January to March, 2018. Data were collected from 253 newborns admitted to the neonatal intensive care unit by interviewing mothers using structured questionnaires and followed for seven completed days of life (day 0 to 6).Kaplan Meier curves were used to estimate survival time, Log-rank test was used to look statistical differences among/between the categories of variables and Cox regression model was used to identify potential predictors of early neonatal deaths. The analysis was conducted using a computer program Stata version 12.Results: Overall, in this study 32 (12.65%) neonates died which makes the early neonatal mortality rate 126.5 per 1000 live births. The median survival time of early neonates was 2 days. Predictors of early neonatal mortality were very low birth weight (AHR= 3.02; 95 % CI: 1.11, 8.25) and preterm birth (AHR=3.7; 95 % CI: 1.22, 11.188). Conclusion: This study shows high incidences of early neonatal mortality. Very low birth weight and preterm birth were major predictors for early neonatal mortality. Managing complications of preterm and very low birth weight, preventing preterm delivery and improving quality of services and ensuring a continuum of care are recommended to increase survival of early neonate