bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation
Authors: Ren Xueyang , Tang Wenjie , Yuan Yuehui , Chen Shisheng , Lu Fangzhou , Mao Jinyang , Fan Jidan , Wei Xufeng , Chu Ming , Hu Benhui 
Published: December 2024

AbstractImplantable peripheral nerve electrodes are crucial for monitoring health and alleviating symptoms of chronic diseases. Advanced compliant electrodes have been developed because of their biomechanical compatibility. However, these mechanically tissue‐like electrodes suffer from unmanageable operating forces, leading to high risks of nerve injury and fragile electrode‐tissue interfaces. Here, a peripheral nerve electrode is developed that simultaneously fulfills the criteria of body temperature softening and tissue‐like modulus (less than 0.8 MPa at 37 °C) after implantation. The central core is altered from the tri‐arm crosslinker to the star‐branched monomer to kill two birds (close the translation temperature to 37 °C and decrease the modulus after implantation) with one stone. Furthermore, the decreased interfacial impedance (325.1 ± 46.9 Ω at 1 kHz) and increased charge storage capacity (111.2 ± 5.8 mC cm−2) are achieved by an in situ electrografted conductive polymer on the strain‐insensitive conductive network of Au nanotubes. The electrodes are readily wrapped around nerves and applied for long‐term stimulation in vivo with minimal inflammation. Neuromodulation experiments demonstrate their potential clinical utility, including vagus nerve stimulation in rats to suppress seizures and alleviation of cardiac remodeling in a canine model of myocardial infarction.
Bistable Soft Shells for Programmable Mechanical Logic
Authors: Yang Nan , Lan Yuming , Zhao Miao , Shi Xiaofei , Huang Kunpeng , Mao Zhongfa , Padovani Damiano 
Published: December 2024

AbstractMechanical computing promises to integrate semiconductor‐based digital logic in several applications, but it needs straightforward programmable devices for changing computing rules in situ. A methodology based on strain‐governed, bistable soft shells that process digital information by interchanging their internal/external surfaces is proposed. This bistable behavior, explained via model‐based design, safeguards robustness by working only once for each input pulse. Thus, these shells are leveraged to create a buffer and a NOT gate that lead to six fundamental gates (AND, OR, NAND, NOR, XOR, and XNOR). All these functions are integrated into a unique programmable device, making mechanically integrated circuits more adaptable with rule‐changeable logic operations. This design ensures continuous processes and general applicability to multiple types of signals (a pressurized fluid can replace mechanical driving signals is shown). It also empowers more complex logic functions suitable for expanded applications, such as the half and full adders is addressed.
Weakening origin of hydrogen bond in ionic liquid at the electrified interface
Authors: Lu Junfeng , Sun Tinglan , Lu Yumiao , He Hongyan , Wang Yanlei 
Published: December 2024

AbstractHydrogen bonds (HBs) widely exist in applications ranging from biology to electrochemistry, where quantifying HB at the electrochemical interface poses significant challenges. Herein, we propose an approach to quantitatively decouple the electrostatic and van der Waals interactions of HBs in ionic liquids (ILs) by injecting electrons into the electrode interface. The charging process showed that the order of obtaining electrons is molybdenum disulfide > graphene > IL > boron nitride. Interestingly, the preferentially charged cations would lead to a direct reduction of coulombic interactions in HBs; in contrast, the charged substrate would repel the anion and weaken HBs indirectly. Infrared (IR) spectrum and covalent change analysis verified the charging‐induced direct and indirect decoupling processes. Moreover, the energy analysis indicates that the electrostatic terms account for ~50% of HBs. These results on the weakening origin of HBs can guide the molecular design of ILs toward high‐performance electrochemical applications.
Association of ten VEGF family genes with Alzheimer's disease endophenotypes at single cell resolution
Authors: Wu Yiyang , Libby Julia B. , Dumitrescu Logan , De Jager Philip L. , Menon Vilas , Schneider Julie A. , Bennett David A. , Hohman Timothy J. 
Published: December 2024

AbstractINTRODUCTIONUsing a single‐nucleus transcriptome derived from the dorsolateral prefrontal cortex of 424 Religious Orders Study and the Rush Memory and Aging Project (ROS/MAP) participants, we investigated the cell type–specific effect of ten vascular endothelial growth factor (VEGF) genes on Alzheimer's disease (AD) endophenotypes.METHODSNegative binomial mixed models were used for differential gene expression and association analysis with AD endophenotypes. VEGF‐associated intercellular communication was also profiled.RESULTSHigher microglia FLT1, endothelial FLT4, and oligodendrocyte VEGFB are associated with greater amyloid beta (Aβ) load, whereas higher VEGFB expression in inhibitory neurons is associated with lower Aβ load. Higher astrocyte NRP1 is associated with lower tau density. Higher microglia and endothelial FLT1 are associated with worse cognition performance. Endothelial and microglial FLT1 expression was upregulated in clinical AD patients compared to cognitively normal controls. Finally, AD cells showed a significant reduction in VEGF signaling compared to controls.DISCUSSIONOur results highlight key changes in VEGF receptor expression in endothelial and microglial cells during AD, and the potential protective role of VEGFB in neurons.Highlights
The prefrontal cortical expression of FLT1 and FLT4 was associated with worse cross‐sectional global cognitive function, longitudinal cognitive trajectories, and more Alzheimer's disease (AD) neuropathology.
The associations between FLT1 or FLT4 and AD endophenotypes appear to be driven by endothelial and microglial cells.
VEGFB expression seems to have opposing effects on the Aβ burden in AD depending on cell types, highlighting its potential protective role in neurons.
Influence of medical conditions on the diagnostic accuracy of plasma p‐tau217 and p‐tau217/Aβ42
Authors: Olvera‐Rojas Marcos , Sewell Kelsey R. , Karikari Thomas K. , Huang Haiqing , Oberlin Lauren E. , Zeng Xuemei , Morris Jill K. , Collins Audrey M. , Drake Jermon A. , Sutton Bradley P. , Kramer Arthur F. , Hillman Charles H. , Vidoni Eric D. , Burns Jeffrey M. , Kamboh M. Ilyas , McAuley Edward , Marsland Anna L. , Chen Yijun , Lafferty Tara K. , Sehrawat Anuradha , Jakicic John M. , Wan Lu , Kang Chaeryon , Erickson Kirk I. 
Published: December 2024

AbstractINTRODUCTIONBlood‐based biomarkers (BBMs) can enable early detection of brain amyloid beta (Aβ) pathology in cognitively unimpaired individuals. However, the extent to which common medical conditions affect biomarker performance remains unclear.METHODSParticipants (n = 348) included individuals without cognitive impairment. We studied how brain Aβ associated with BBMs (Aβ42/40, phosphorylated tau [p‐tau] 181 and 217, p‐tau217/Aβ42, glial fibrillary acidic protein [GFAP], and neurofilament light [NfL]) and optimal BBM thresholds for predicting brain Aβ positivity and whether they are obscured by the presence of common medical conditions.RESULTSPlasma Aβ42/40, p‐tau181, p‐tau217, and GFAP, but not NfL, were significantly associated with brain Aβ. P‐tau217/Aβ42 showed the best discriminative performance (area under the curve: 0.91). The strength of p‐tau217–brain Aβ associations were obscured by diabetes and cardiovascular conditions.DISCUSSIONThese results suggest BBMs may help detect early Aβ pathology but suggest caution in their use due to common medical conditions that could affect accuracy.Highlights
Plasma Aβ42/40, p‐tau181, p‐tau217, and GFAP but not NfL showed significant associations with brain Aβ.
BBMs were more strongly associated with the level of brain Aβ in those without diabetes and cardiovascular conditions.
P‐tau217/Aβ42 showed the best performance (AUC = 0.91) in discriminating Aβ presence with an optimal cut‐off of >1.2, followed by p‐tau217 at >0.46 pg/mL, with performance slightly improving when excluding participants with cardiovascular conditions.
Highly Efficient and Stable Perovskite Solar Cells by Introducing a Multifunctional Surface Modulator
Authors: Zhuang Rongshan , Wang Peng , Wang Linqin , Lai Qian , Qiu Junming , Chen Yinjuan , Zhang Xiaoliang , Sun Licheng , Hua Yong 
Published: December 2024

AbstractSimultaneously passivating the perovskite surface defects and suppressing Li+ ions diffusion of hole transport layer (HTL) are still challenging issues. Herein, we report an effective “ three birds with one stone ” strategy by utilizing sodium 4,4′‐(1,4‐phenylenebis(oxy))bis(butane‐1‐sulfonate) (ZR3) containing sulfonic acid groups (SO3−) and Na+ ions as a multifunctional surface treatment modulator to simultaneously address the above issues. It is found that ZR3 is not only capable of passivating the Pb‐related defects at the surface of perovskite by the SO3− group, but also possesses the remarkable ability to passivate the halide defects with Na+ ions. Meanwhile, ZR3 treatment enables the enhanced exciton dissociation of perovskite, better energy level alignment with hole transport layer (HTL), improved hole extraction/transfer from perovskite layer into HTL, and reduced charge carrier recombination in device. Therefore, it results in the enhanced power conversion efficiency (PCE) of 25.34 % in ZR3‐based n‐i‐p device from 22.97 % for the control device. Specifically, p‐i‐n PSCs with ZR3 also achieves an improved PCE of 25.96 % with respect to the pristine one (23.99 %), proving the universality of ZR3 for PSCs. Moreover, the stabilities of ZR3‐treated devices are significantly enhanced owing to Li+ ions migration suppressing and perovskite defects reduction.
Balancing Activity and Selectivity in Two‐Electron Oxygen Reduction through First Coordination Shell Engineering in Cobalt Single Atom Catalysts
Authors: Sun Kai , Lu Ruihu , Liu Yuge , Webb Joshua , Hanif Muhammad , Zhao Yufei , Wang Ziyun , Waterhouse Geoffrey I. N. 
Published: December 2024

AbstractThe electrochemical two‐electron oxygen reduction reaction (2e− ORR) offers a potentially cost‐effective and eco‐friendly route for the production of hydrogen peroxide (H2O2). However, the competing 4e− ORR that converts oxygen to water limits the selectivity towards hydrogen peroxide. Accordingly, achieving highly selective H2O2 production under low voltage conditions remains challenging. Herein, guided by first‐principles density functional theory (DFT) calculations, we show that modulation the first coordination sphere in Co single atom catalysts (Co−N−C catalysts with Co‐NxO4‐x sites), specifically the replacement of Co−N bonds with Co−O bonds, can weaken the *OOH adsorption strength to boost the selectivity towards H2O2 (albeit with a slight decrease in ORR activity). Further, by synthesizing a series of N‐doped carbon‐supported catalysts with Co‐NxO4‐x active sites, we were able to validate the DFT findings and explore the trade‐off between catalytic activity and selectivity for 2e− ORR. A catalyst with trans‐Co‐N2O2 sites exhibited excellent catalytic activity and H2O2 selectivity, affording a H2O2 production rate of 12.86
and an half‐cell energy‐efficiency of 0.07
during a 100‐hours H2O2 production test in a flow‐cell.
High‐Efficiency Perovskite Solar Cells Enabled by Guanylation Reaction for Removing MACl Residual and In‐Situ Forming 2D Perovskite
Authors: Xie Zhuang , Duan Yuwei , Cheng Minghui , Li Yong , Liu Zhike , Li Hongxiang , Chen Yu , Zang Zhigang , Liu Shengzhong , Peng Qiang 
Published: December 2024

AbstractThe thermodynamical deprotonation of methylammonium chloride (MACl) has several detrimental influences on the quality of formamidinium (FA+)‐based perovskite, which limits both efficiency and stability of inverted perovskite solar cells (IPSCs). Herein, a new additive strategy was developed by introducing methyl carbamimidothioate hydroiodide (MCH) into perovskite precursor, where guanylation reaction occurred between MCH and MACl to form a new intermediate of methyl‐substituted guanidine (MSG). MSG could then bond with undercoordinated Pb2+ to in situ form a two‐dimensional (2D) perovskite, which would promote the growth and crystallization of three‐dimensional (3D) perovskite with higher crystallinity, lower defect‐states density and superior stability. Finally, the MCH‐treated IPSC with a small area (0.09 cm2) achieved an impressive power conversation efficiency (PCE) of 26.81 % (certified as 26.02 %), which is one of the highest PCEs reported to date. The large area MCH‐treated device (1.00 cm2) also obtained a high PCE of 24.36 %. Moreover, the unencapsulated and MCH‐treated device exhibited excellent operational stability, maintaining 91.95 % and 97.06 % of their initial efficiencies after aging in air and a nitrogen‐filled atmosphere at 85 °C for 1200 h. The encapsulated MCH‐treated devices retained 94.25 % of its initial efficiency after continuously tracking at the maximum power‐point for 1200 h in air.
Titanium‐Catalyzed Reaction of Silacyclobutanes with Alkenes: Mimicking the Reactivity and Reversing the Selectivity Towards Late Transition Metals
Authors: Wang Yaqiong , Zhang Jiong , Wang Fang , Wu Lipeng 
Published: December 2024

AbstractTransition metal‐catalyzed ring opening and expansion reactions of silacyclobutanes (SCBs) constitute an atom‐ and step‐economical strategy to construct value‐added silicon‐containing chemicals. Despite extensive studies, the reaction of SCBs with simple alkenes has only one precedent. Moreover, most reported reactions of SCBs use late transition metals (Pd, Ni, Rh) as catalysts. By contrast, there are no reports of using early transition metals. Herein, we report the first example, to our knowledge, of early‐transition‐metal‐catalyzed reactions of SCBs using earth's second abundant titanium as a catalyst. Notably, orthogonal selectivity was observed. Selective activation of the relatively inert C(sp3)−Si bond was achieved in the case of benzosilacyclobutenes, a selectivity that has rarely been achieved using other metals. Even for silacyclobutanes with C(sp3)−Si bonds only, our titanium system also shows complementary selectivity towards late transition metals to give distinct products. Thus, structurally varied SCBs and alkenes were reacted in our system to afford structurally diverse silicon‐containing products that are otherwise difficult to obtain using other transition metals.
Chiroptical Amplification of [7]‐Helicene Nanographene by Additional Helical Chirality
Authors: Dongre Sangram D. , Venugopal Geethu , Kumar Viksit , Badrinarayan Jadhav Ashok , Kumar Jatish , Santhosh Babu Sukumaran 
Published: December 2024

AbstractNanographenes have captivated scientific interest since the pioneering discovery of graphene. Recently, attention has shifted towards exploring chiral and nonplanar nanographenes, for their distinct optical, chiroptical, and electronic properties. Despite the growing acceptance of helicenes, the research on inducing helical chirality on π‐extended derivatives to boost chiroptical properties remains unattended. In our study, we introduce a new π‐extended [7]‐helicene resulting from the condensation of diamines with 3,6‐dibromophenanthrene‐9,10‐dione, complemented by two hexabenzocoronene arms in the periphery. Notably, the nanographene containing binaphtho‐[1,4]diazocine, compared to the corresponding phenazine, exhibits a remarkable average 2.5, 5, and 10‐fold enhancements in quantum yield, dissymmetry factor, and brightness, respectively, when measured in five different solvents. These improvements underscore the significance of the induced helical chirality by the antiaromatic binaphtho‐[1,4]diazocine in influencing the chiroptical properties of the helical nanographene. Our research represents a significant stride toward unlocking the potential of π‐extended helicenes and lays the groundwork for further exploration in designing and synthesizing new chiral nanomaterials.
Harnessing of Cooperative Cu⋅⋅⋅H Interactions for Luminescent Low‐Coordinate Copper(I) Complexes towards Stable OLEDs
Authors: Zhang Qizheng , Li Nengquan , Wan Xintong , Song Xiu‐Fang , Zhang Yi , Liu He , Miao Jingsheng , Zou Yang , Yang Chuluo , Li Kai 
Published: December 2024

AbstractAlthough two‐coordinate Cu(I) complexes are highly promising low‐cost emitters for organic light‐emitting diodes (OLEDs), the exposed metal center in the linear coordination geometry makes them suffer from poor stability. Herein, we describe a strategy to develop stable carbene‐Cu‐amide complexes through installing intramolecular noncovalent Cu⋅⋅⋅H interactions. The employment of 13H‐dibenzo[a,i]carbazole (DBC) as the amide ligand leads to short Cu⋅⋅⋅H distances in addition to the Cu−N coordination bond. The resultant Cu(I) complexes exhibit yellow thermally activated delayed fluorescence with photoluminescence quantum yields of up to 86 % and radiative decay rate constants on the order of 106 s−1. Comparing with the analogues without Cu⋅⋅⋅H interactions, the pincer complexes have significantly improved stability. The vacuum‐deposited OLEDs show high‐performance electroluminescence with maximum external quantum efficiencies of up to 29.5 % and extremely small roll‐offs of only 3.5 % at 10,000 cd m−2. Remarkably, the operational lifetimes (LT90) are up to 68 h with an initial luminance of 3000 cd m−2. This work proves a feasible design of robust low‐coordinate metal complexes by leveraging secondary coordination interactions, which helps to overcome the long‐standing stability problem.
Unveiling Interference‐Free Acridine‐Calix[4]Arene‐Based Fluorescence paper and Electrochemical Sensor for Cyanazine from Agricultural Produces
Authors: Soni Heni , Shukla Malvika , Chaudhari Divyesh , Gandhi Sahaj , Pandya Alok , Sutariya Pinkesh G. 
Published: December 2024

AbstractThe construction of fluorescence sensor L1 for cyanazine (CNZ) by using calix[4]arene scaffold allied with 9‐Aminoacridine moiety has been reported. The recognized triazine herbicide CNZ decreased the fluorescence intensity of L1 by exhibiting “turn‐off” phenomenon having detection limit to be 7.79 μM obtained from emission study. The quenching response of L1: CNZ was observed between the range of 5–105 μM possessing binding constant calculated to be 9.201×106 M−1. The spiking experiment of CNZ into L1 has also been performed to evaluate potency of L1 using vegetables and cereals. Also, a paper‐based device has been prepared in order to implement this strategy for on‐spot monitoring of CNZ. The L1:CNZ binding has been confirmed by conducting electrochemical studies like cyclic voltammetry, differential pulse voltammetry, 1H NMR, FT‐IR, MALDI‐TOF, 1H NMR titration, PXRD investigation and computational analysis.
A Supramolecular Gel‐Based Protocol for the Detection of α‐Glycosidases for Screening Potential Drugs
Authors: Sakthivel Shruthi , Chaturvedi Pankaj Kumar , Maitra Uday 
Published: December 2024

Abstractα‐Glycosidases are carbohydrate‐digesting enzymes that catalyze the hydrolysis of α‐1,4‐glycopyranoside bonds from oligosaccharides and disaccharides. α‐Glucosidase is an important biomarker for the diagnosis of type‐II diabetes, Azoospermia and Pompe diseases. Additionally, the mutations in α‐galactosidase lead to Fabry disease. Inhibitors targeting these enzymes are prescribed as anti‐diabetic medications and as effective chaperones for Fabry disease. Comprehending the function – regulation of α‐glycosidases requires accurate quantification methods. In this work, we highlight the design of a simple luminescent ‘turn‐on’ assay for sensing these two α‐glycosidases in a supramolecular TbCh hydrogel matrix using 1‐α‐glycosides as pro‐sensitizers. The protocol offers a cost‐effective method for selectively sensing α‐glycosidases in the detection limit of the subnanomolar range. Importantly, the developed enzyme sensors functioned as a platform for rapid screening of drug molecules based on their inhibition potency. Therefore, the protocol is useful for facilitating the advancement of therapeutics and diagnostics targeting this important class of enzymes.
Exploring the Clinical Signatures of Cervical Dysplasia Patients and Their Association With Vaginal Microbiota
Authors: Cheng Liqin , Yan Chunmei , Yang Yongxia , Hong Fanzhen , Du Juan 
Published: December 2024

ABSTRACTAimsThe vaginal microbiota plays a crucial role in women's health, and an imbalanced vaginal microbiota is linked to various diseases, including human papillomavirus (HPV) infection. However, most available data comes from Western countries and primarily focuses on HPV infection, with only a few studies considering detailed clinical factors to explore the relationship between vaginal microbiota and the development of cervical cancer, especially in China.Materials and MethodsOur study involved 266 women, including individuals at all stages of cervical dysplasia, and healthy controls with and without HPV infection. We assessed several aspects of the vaginal environment, including vaginal microbiota composition using 16S rRNA gene sequencing, HPV infection status using the standard Roche Cobas method, pH value, age, and H2O2 levels from clinical records, and partner numbers and contraceptive methods obtained through questionnaires. The association of these clinical signatures with cervical dysplasia stages and vaginal microbiota was analyzed.Key FindingsOur findings demonstrate a significant association between vaginal microbiota and cervical dysplasia stages. Patients with cervical dysplasia and cancer showed a substantial increase in HPV 16 infection, a higher prevalence of pH > 5, a lower H2O2 level, and older ages compared to healthy individuals. Additionally, these factors influence the beta diversity of the vaginal microbiota.SignificanceThese results underscore the importance of considering the vaginal microbiota within the cancer microenvironment and highlight the need to integrate all available data to aid in the current diagnosis and understanding of cervical dysplasia and the cervical cancer microenvironment.
Multi‐Omics Analysis of the Molecular Mechanisms by Which Extract of Artemisia selengensis Turcz. Ameliorates DBP‐Induced Liver Injury
Authors: Guan Wenying , Jiang Xiaotan , Yu Xiaohua , Li Xinwei , Li Kangxing , Liu Huan , Wang Xinyi , Liu Xixia , Hou Jianjun , Wu Qin , Liu Chunhong 
Published: December 2024

ABSTRACTArtemisia selengensis Turcz. is a perennial herb belonging to the genus Artemisia in the family Asteraceae. Known for its nutrient richness, distinct flavor, and medicinal properties, Artemisia selengensis Turcz. has garnered attention. However, its efficacy, particularly in alleviating hepatic injury, remains underexplored. This study aims to assess the therapeutic potential of the 50% ethanol extract of Artemisia selengensis Turcz. (ASTE) in a mouse model of dibutyl phthalate (DBP)‐induced liver injury. Through multi‐omics analysis, including transcriptomics, metabolomics, and intestinal flora examination, we explored the pathways and key targets of ASTE in treating liver injury. Network pharmacology further identified the crucial components of ASTE for liver injury treatment. Our findings indicate that ASTE affects intestinal flora such as Adlercreutzia through flavonoids, particularly naringin and epicatechin. Additionally, key genes in the PPAR pathway, such as fatty acid–binding protein 3 (Fabp3), fatty acid–binding protein 5 (Fabp5), 3‐hydroxyacyl‐CoA dehydrogenase (Ehhadh), and phospholipid transfer protein (Pltp), influence glycerophospholipid metabolism, contributing to liver injury amelioration. This study sheds light on the molecular mechanisms underlying ASTE's hepatoprotective effects, laying the groundwork for its potential application as a functional food.