bluuebunny/crossref_metadata_2025_split huggingface dataset:
A narrative study of newly graduated registered Swedish nurses’ establishment in the profession and the portrayal of a healthcare organisation
Authors: Blomberg Helena , Welander Jonas 
Published: June 2019

Purpose
The purpose of this paper is to investigate how the participants talk about their experiences as newly graduated nurses, managers and nursing colleagues in the context of “newcomers’ establishment in the profession” and to identify how they portray the healthcare organisation in their narratives.

Design/methodology/approach
A narrative approach is used to reveal and illustrate three perspectives on the topic “new-comers’ establishment”. In total, 14 interviews are conducted with 4 managers, 4 nursing colleagues and 6 newly graduated registered nurses. The focus of this study is how a healthcare organisation embraces and retains newly graduated registered nurses and how this is perceived.

Findings
The newcomers’ establishment is facilitated by an orientation programme and an orientation period, individual support provided by managers and colleagues, and the creation of trust to boost confidence in nursing situations. The organisation is portrayed as struggling with high workloads, nursing shortages, high levels of responsibility and showing concern and an interest in the newcomer. The parties criticise the university for not teaching the most basic knowledge, thereby revealing the existence of a theory-practice gap.

Originality/value
The research shows how building trust amongst the organisation’s members is essential for creating a satisfying workplace and the retention of newly graduated registered nurses. Empirical descriptions of newly graduated nurses, managers and nursing colleagues experiences of “newcomers establishment” are rare, which is why the description of such “establishment” in this research increases the value of the paper.
Persuasive speech in multi-professional change facilitation meetings
Authors: Komulainen Hanna , Mertaniemi Elisa , Lunkka Nina , Jansson Noora , Meriläinen Merja , Wiik Heikki , Suhonen Marjo 
Published: June 2019

Purpose
The purpose of this paper is to describe persuasive speech and discourses in multi-professional organizational change facilitation meetings at a hospital through rhetorical discourse analysis. Previous research has often considered organizational change to be a managerial issue, with other employees given the rather passive role of implementators. This study takes an alternative approach in assuming that organizational change could benefit by involving those who are most familiar with the tasks to be changed.

Design/methodology/approach
The study employed a qualitative, case study approach and focused on the construction of a hospitalist model within multi-professional change facilitation meetings. Eight videos of these multi-professional change facilitation meetings – which occurred between January and September 2017 – were observed and the material was analyzed by rhetorical discourse analysis. An average of 10–20 actors from different professional groups participated in the meetings. The change actors comprised physicians, nursing staff and nursing managers, along with a secretary and hospitalist. The meetings were conducted by a change facilitator.

Findings
The persuasive speech in the analyzed organizational change meetings occurred within five distinct discourses: constructing the change together, positive feedback, strategic change in speech, patient perspective and driving change. The content of these discourses revealed topics that are relevant to persuading members of healthcare organizations to adopt a planned change.

Originality/value
The presented research provides new knowledge about how persuasive speech is used in organizational change and describes the discourses in which persuasive speech is used in a healthcare context.
Entrepreneurial passion and venture performance: a proposed framework
Authors: Iyortsuun Akuraun Shadrach , Nmadu Mwuese Theresa , Dakung Reuel , Gajere Monica C. 
Published: June 2019

PurposeThis paper aims to attempt to synthesize the evidence in literature on the link between passion and passion outcomes to propose a parsimonious framework of entrepreneurial passion and venture performance based on the theory of social cognition, identity and self-regulation.Design/methodology/approachA detailed review of empirical and conceptual articles related to the topic was the adopted methodology. An eclectic synthesis of the evidence guided the development of the framework as proposed.FindingsEmpirical review of the related studies reveals that the link between entrepreneurial passion and venture performance is distal. Based on the theoretical foundation of the study, entrepreneurial passion is proposed to have a direct link on venture performance and an indirect link mediated by goal-setting, entrepreneurial behavior and entrepreneurial self-efficacy. Control variables proposed include age, sex, size, work experience or tenure and self-regulation or feedback.Research limitations/implicationsEntrepreneurial passion is conceived as an experienced construct conceptualized as the interaction of intense positive feeling and identity centrality associated with venture outcomes defined as opportunity recognition, venture creation/growth and threshold performance.Practical implicationsThe study provides a parsimonious framework of entrepreneurial passion and venture performance that includes goals, entrepreneurial behavior and self-efficacy as mediator variables and age, sex, size, work experience or tenure and self-regulation or feedback as control variables.Originality/valueThe framework extends the ontological field of entrepreneurial passion, which can be validated by empirical research.
Exploring the moderating effect of susceptibility to emotional contagion in the crossover of work–family conflict in supervisor–subordinate dyads in India
Authors: Baral Rupashree , Sampath Pavithra 
Published: June 2019

PurposeThe purpose of this paper is to study the applicability of a crossover model of work–family conflict (WFC) in the work setting among supervisor–subordinate dyads. It examines the positive association between supervisor’s WFC and subordinate’s WFC and analyses the moderating effect of subordinate’s susceptibility to emotional contagion (SEC).Design/methodology/approachData were gathered using a questionnaire survey method and tested in 193 matched supervisor–subordinate dyads from select organisations representing the services sector in India.FindingsThe authors found a significant direct crossover path from the supervisor to his/her subordinate’s WFC. The effect of supervisor reported WFC on subordinate reported WFC was found to be strong when the subordinate displayed higher SEC with his/her supervisor.Research limitations/implicationsExamining the crossover of WFC contributes to theory by broadening crossover research to include transmission of negative experiences in the work context. This study significantly adds to emotional contagion theory by substantiating the existence of WFC contagion in supervisor–subordinate dyads. Given the constraints of cross-sectional research design, future research should replicate these findings using a larger sample in other cultural contexts as well to generalise the results. Future research should consider using longitudinal data and including information from both the supervisor and the subordinates collected at different points in time. Crossover of positive work–family experiences (e.g. work–family enrichment) and the role of other individual difference variables such as the personality of the subordinates, empathy, etc., could also be considered.Practical implicationsSupervisors should be advised of the potential adverse effects of their WFC and organisations should be made cognizance of the impact that the WFC of employees can have on their job outcomes. Organisations should provide the required formal and informal support to their employees to deal with their WFC efficiently.Originality/valueThis study has attempted to examine the crossover of WFC in supervisor–subordinate dyads and the potential effect of one of the individual difference variables namely SEC. To the best of the authors knowledge, it has rarely been examined earlier.
Why social enterprises pursue growth? Analysis of threats and opportunities
Authors: Tykkyläinen Saila 
Published: June 2019

PurposeThe purpose of this study is to extend theoretical understanding on social enterprises’ growth orientation. Inspiration is drawn from the fundamentals of prospect theory and threat-rigidity theory, as the role of external threats as a source of growth orientation is largely absent from the social enterprise growth literature. According to previous studies, social enterprises grow mainly because of their social mission and social opportunities.Design/methodology/approachThe qualitative research is conducted by analysing thematic interviews from seven, growth-oriented social enterprises operating in Finland.FindingsThe study provides novel insights on social enterprises’ growth orientation by drawing attention to the plurality of growth motivations and showing the importance of perceived threats as the origin of their growth pursuits. Goals of growth are defined mainly in terms of organisational and financial performance of the firm.Practical implicationsSocial enterprise managers and boards are encouraged to cooperate in analysing the significance of external threats and opportunities for their business and to concentrate on defining measurable social goals to ensure balanced growth.Originality/valueThe study demonstrates that the behavioural theories offer a beneficial departure point for studying social venture growth. By clarifying the role of the perceptions of the firm’s internal actors and showing that growth is sometimes seen as a response to external threats, the study increases theoretical understanding on social enterprises’ growth orientation.
Metabolic engineering ofBacillus amyloliquefaciensLL3 for enhanced poly‐γ‐glutamic acid synthesis
Authors: Gao Weixia , He Yulian , Zhang Fang , Zhao Fengjie , Huang Chao , Zhang Yiting , Zhao Qiang , Wang Shufang , Yang Chao 
Published: June 2019

SummaryPoly‐γ‐glutamic acid (γ‐PGA) is a biocompatible and biodegradable polypeptide with wide‐ranging applications in foods, cosmetics, medicine, agriculture and wastewater treatment.Bacillus amyloliquefaciensLL3 can produce γ‐PGAfrom sucrose that can be obtained easily from sugarcane and sugar beet. In our previous work, it was found that low intracellular glutamate concentration was the limiting factor for γ‐PGAproduction byLL3. In this study, the γ‐PGAsynthesis by strainLL3 was enhanced by chromosomally engineering its glutamate metabolism‐relevant networks. First, the downstream metabolic pathways were partly blocked by deletingfadR,lysC,aspB,pckA,proAB,rocGandgudB. The resulting strainNK‐A6 synthesized 4.84 g l−1γ‐PGA, with a 31.5% increase compared with strainLL3. Second, a strong promoterPC2upwas inserted into the upstream oficdgene, to generate strainNK‐A7, which further led to a 33.5% improvement in the γ‐PGAtitre, achieving 6.46 g l−1. TheNADPHlevel was improved by regulating the expression ofpgiandgndA. Third, metabolic evolution was carried out to generate strainNK‐A9E, which showed a comparable γ‐PGAtitre with strainNK‐A7. Finally, thesrfandituoperons were deleted respectively, from the original strainsNK‐A7 andNK‐A9E. The resulting strainNK‐A11 exhibited the highest γ‐PGAtitre (7.53 g l−1), with a 2.05‐fold improvement compared withLL3. The results demonstrated that the approaches described here efficiently enhanced γ‐PGAproduction inB. amyloliquefaciensfermentation.
Towards PacBio‐based pan‐eukaryote metabarcoding using full‐length ITS sequences
Authors: Tedersoo Leho , Anslan Sten 
Published: June 2019

SummaryDevelopment of high‐throughput sequencing techniques has greatly benefited our understanding about microbial ecology, yet the methods producing short reads suffer from species‐level resolution and uncertainty of identification. Here, we optimize Pacific Biosciences‐based metabarcoding protocols covering the internal transcribed spacer (ITS region) and partial small subunit of the rRNA gene for species‐level identification of all eukaryotes, with a specific focus on Fungi (including Glomeromycota) and Stramenopila (particularly Oomycota). Based on tests on composite soil samples and mock communities, we propose best suitable degenerate primers, ITS9munngs + ITS4ngsUni for eukaryotes and selected groups therein and discuss the pros and cons of long read‐based identification of eukaryotes.
Pathological outcomes of HER2‐positive non‐metastatic breast cancer patients treated with neoadjuvant dual anti‐HER2 therapy and taxane: An Australian experience
Authors: Choi Joseph Do Woong , Hughes Thomas Michael D. , Marx Gavin , Rutovitz Josie , Hasovits Csilla , Ngui Nicholas K. 
Published: June 2019

AbstractAimsInternationally, there has recently been growing interest in the use of neoadjuvant pertuzumab and trastuzumab in patients with non‐metastatic HER‐2 positive breast cancer following the NEOSPHERE trial in 2012. However, pertuzumab is currently not funded by the Pharmaceutical Benefits Scheme (PBS) in Australia for use in this setting. The authors sought to assess the clinical and pathological response rates at the time of surgery in patients who received neoadjuvant dual anti‐HER2 and taxane therapy in a multidisciplinary breast cancer unit.MethodsA retrospective case series of all patients treated with the neoadjuvant therapy, and who had definitive surgery was conducted. Demographic data, size, grade, tumor type, receptor status prior to neoadjuvant treatment, pathological complete response (pCR) rates, and adverse effects were analyzed.ResultsNineteen patients were included in the study. Sixty‐eight percent of all patients achieved pCR, of which 54% further demonstrated no residual ductal carcinoma in situ. Eight patients (42%) had N1 disease pretreatment, of these 88% demonstrated total pCR in the axilla and the breast. Most adverse effects to treatment were manageable grade 1–2 side effects.ConclusionThis is the first reported Australian experience using neoadjuvant dual anti‐HER2 and taxane therapy for HER‐2 positive nonmetastatic breast cancer. The authors have demonstrated favorable pCR rates for invasive disease compared to the NEOSPHERE trial (68% vs 46%), with reasonable patient tolerability. Larger collaborative data sets are required to fully evaluate correlation of pCR with survival outcomes, and cost‐effectiveness. National funding models need to be considered.
Late diagnosis and poor nutrition in cystic fibrosis diagnosed before implementation of newborn screening
Authors: Pedersen Maya Graham , Højte Christine , Olesen Hanne Vebert , Pressler Tania , Skov Marianne 
Published: June 2019

AbstractAimDenmark has a high standard cystic fibrosis care. However, newborn screening was not implemented until 2016. This article describes the clinical status of cystic fibrosis patients at time of diagnosis prior to newborn screening.MethodsPatients diagnosed with cystic fibrosis in Denmark in 2010‐2014 were reviewed using the Danish Cystic Fibrosis Registry as well as patient files. Parameters collected were age at diagnosis, gender, weight, height, forced expiratory volume at 1 second, cystic fibrosis transmembrane regulator‐genotype, lung bacteriology at diagnosis and previous diagnoses.ResultsA total of 63 patients were diagnosed in the study period. The most typical pre‐cystic fibrosis diagnoses were asthma and pneumonia. The median age at diagnosis was 1.4 years for the pancreatic insufficient and 27.3 years for the pancreatic sufficient patients. Of the pancreatic insufficient patients, 21% had moderate to severe malnutrition with BMI below minus 2 SD and 40% had moderate to severe stunting with height below minus 2 SD.ConclusionDiagnosis was delayed considerably compared to diagnosis by newborn screening in other countries. Many cystic fibrosis patients diagnosed due to clinical symptoms were moderately to severely underweight or stunted at diagnosis.
Back pain is more frequent in girls and in children with scoliosis in the context of cerebral palsy
Authors: Hägglund Gunnar , Czuba Tomasz , Alriksson‐Schmidt Ann I. 
Published: June 2019

AbstractAimTo investigate the prevalence of general and back pain in children with cerebral palsy and the relationships between scoliosis and back pain.MethodsCross‐sectional register study based on data from the Swedish Cerebral Palsy Follow‐Up Programme. Descriptive analyses and logistic regression to regress age, sex, gross motor function, windswept, hip extension and source of report on the presence of pain.ResultsThe study included 3783 children (58% boys) 1‐18 (mean 10.0) years of age. General pain was reported in 1538 (44% girls, 38% boys) and back pain in 226 (7% girls, 5% boys) children. The proportion of back pain increased from <4% prior to age 12 years to >12% from 16 years of age. Back pain increased from 4% in children without scoliosis to 16% in children with severe scoliosis. Moderate/severe back pain increased from 2% in children without scoliosis to 10% in children with severe scoliosis. Increased odds of reporting back pain were found for age, girls, low gross motor function and children with scoliosis.ConclusionThe proportion of children with general pain increased with age and was more frequent in girls. Age, female sex, low gross motor function and scoliosis were significant predictors of back pain.
Overrepresentation of epilepsy in children with type 1 diabetes is declining in a longitudinal population study in Finland
Authors: Sillanpää Matti , Saarinen Maiju M. , Rönnemaa Tapani , Gissler Mika , Schmidt Dieter 
Published: June 2019

AbstractAimThe aim was to determine temporal changes in increased risk of epilepsy among children with type 1 diabetes.MethodsThe incidence of epilepsy up to age 15 in children with prior type 1 diabetes was analysed regarding the general Finnish child population using data from the Finnish nationwide hospital register. Type 1 diabetes and epilepsy were identified by the International Classification of Diseases 9th and 10th revision codes. Epilepsy was defined according to ILAE guidelines. The analyses were done using negative binomial regression models.ResultsPreceding type 1 diabetes was diagnosed in 6162 (0.91%) of the 679 375 general children population. Incidence rate of new‐onset epilepsy among children with type 1 diabetes was higher than in controls (140 vs 82 per 100 000 person‐years at risk, respectively). The excess incidence diminished with time (P = 0.033 for diabetes to birth cohort interaction), from over twofold in birth cohort 1990‐1993 [incidence rate ratio 2.2 (95% CI 1.7‐2.9)] to 40% in birth cohort 1998‐2000 [1.4 (95% CI 1.001‐1.9)].ConclusionIn a population study setting, children with type 1 diabetes had an increased, but slowly declining risk of developing epilepsy. Future research may elucidate the underlying mechanisms.
Prognostic significance of α‐ and β2‐adrenoceptor gene expression in breast cancer patients
Authors: Rivero Ezequiel Mariano , Martinez Leandro Marcelo , Bruque Carlos David , Gargiulo Lucia , Bruzzone Ariana , Lüthy Isabel Alicia 
Published: June 2019

AimsBreast cancer is the most frequently diagnosed and leading cause of cancer death among women worldwide. It was classified within molecular intrinsic subtypes: luminal A, luminal B, human epidermal growth factor receptor 2‐enriched and basal‐like. Epinephrine and norepinephrine, released during stress, bind to adrenoceptors. α2‐adrenoceptors are encoded by the ADRA2A, ADRA2B and ADRA2C genes and β2 by ADRB2.MethodsWe compiled several publicly available Affymetrix gene expression datasets, obtaining a large cohort of 1924 patients with distant metastasis‐free survival (DMFS) data and evaluated the association between adrenoceptor expression, clinicopathological markers and outcome.ResultsADRA2A high expressing tumours also expressed hormone receptors and presented diminished tumour size, grade and not compromised lymph nodes. ADRB2 high expression was found in smaller, low grade, oestrogen receptor‐positive tumours. Both were significantly associated with the absence of metastasis. High expression of ADRA2C was positively associated with increased tumour size and metastatic relapse. We observed a significant increase in DMFS of patients with high ADRA2A (hazard ratio 0.54, 95% CI 0.45–0.65, P < .001) and ADRB2 (0.77, 0.64–0.93, P = .006) expression and a decrease with ADRA2C high expression (1.45, 1.16–1.81, P = .001). For patients with luminal tumours, ADRA2A was the only factor that retained its significance as an independent predictor of DMFS while ADRA2C expression was an independent predictor for worse prognosis in basal‐like tumours.ConclusionsWe herein provide new insight for a potential role of ADRA2A and ADRA2C in breast cancer. In low‐ and medium‐income countries, their incorporation to routine immunohistochemistry analysis of biopsies or tumour samples, could provide additional low‐cost prognostic factors.
Cryptotanshinone ameliorates renal ischaemia–reperfusion injury by inhibiting apoptosis and inflammatory response
Authors: Bai Tao , Yang Kang , Qin Cong , Xu Tao , Yu Xi , Zhang Jie 
Published: June 2019

AbstractCryptotanshinone (CTS) is a natural compound from the Chinese herb Salvia miltiorrhiza. Previous studies demonstrated that CTS possesses anti‐apoptotic and anti‐inflammatory properties. However, its effects and underlying mechanism on renal ischaemia reperfusion (IR) injury remain unknown. In the present study, we investigated the effects of CTS on renal IR injury and its potential underlying mechanisms. Mice were randomized into four groups as follows: (a) sham operation + vehicle, (b) sham operation + CTS, (c) IR + vehicle, (d) IR + CTS. The CTS‐treated group were injected intraperitoneally with CTS (10 mg/kg/d) for 7 days prior to IR operation. Renal IR injury was induced by clamping the bilateral renal artery for 30 minutes followed by 24 hours of reperfusion. The mice were then killed to collect the serum and the kidneys for analysis. The results of the present study showed that CTS pretreatment significantly attenuates IR‐induced renal functional and morphological injuries, which was accompanied with inhibition of cell apoptosis and inflammatory response. Moreover, the phosphorylation of p38 mitogen‐activated protein kinase (MAPK) and the activation of nuclear factor‐κB (NF‐κB) signalling were inhibited by CTS. Therefore, CTS could be a useful therapeutic agent in the fight against renal IR injury.